Document:

Amendment No. 2 to Amended and Restated Employment Agreement

 Exhibit 10.1 
 OREXIGEN THERAPEUTICS, INC. 
 AMENDMENT NO. 2 TO AMENDED AND RESTATED
EMPLOYMENT AGREEMENT 
 NOVEMBER 1, 2011 
 Reference is made to the AMENDED AND RESTATED EMPLOYMENT AGREEMENT dated February 22, 2010 by and
between OREXIGEN THERAPEUTICS, INC. (“Orexigen” or the “Company”) with its principal place of business located at 3344 N. Torrey Pines Ct., Suite
200, La Jolla, CA 92037 and MARK BOOTH (“Executive”), and AMENDMENT NO. 1 TO THE AMENDED
AND RESTATED EMPLOYMENT AGREEMENT dated June 14, 2011, respectively. All capitalized terms used herein and not otherwise defined shall have the meanings assigned to
such terms in the Agreement. 
 WHEREAS, the Company and Executive are parties to that
certain Amended and Restated Employment Agreement (the “Agreement”), as amended pursuant to Amendment No. 1 to Amended and Restated Employment Agreement (the “First Amendment”); 

WHEREAS, the parties desire to supersede and replace in full the First Amendment, and to amend
certain terms of the Agreement in accordance with the terms hereof (this “Second Amendment”). 

NOW THEREFORE, for good and valuable consideration, the receipt and sufficiency of
which is hereby acknowledged by the parties, the parties hereto, intending to be legally bound, agree to amend the Agreement as follows: 
  

	1.	Article II, Section 2.1 of the Agreement shall be amended and restated in its entirety as follows: 

“Position and Duties. Subject to terms set forth herein, the Company agrees to continue to employ Executive, on a Part-Time
Basis (as defined below), in the position of Chief Commercial Officer and Executive hereby accepts such continued employment. Executive shall perform such duties as are customarily associated with the position of Chief Commercial Officer, on a
Part-Time Basis, and such other duties as are assigned to Executive by the Chief Executive Officer and/or President of the Company. Subject to the terms of this Agreement, the Company may change Executive’s duties, responsibilities, title, and
reporting relationship at its discretion. Effective November 1, 2011, and subject to Section 2.2 of the Agreement, Executive will devote Executive’s best efforts and three (3) days (equal to an eight (8) hour day) per week
to the business of the Company (“Part-Time Basis”). Notwithstanding the foregoing, it is agreed and understood that Executive shall be allowed to participate on the boards of directors of two companies and Executive may serve
on other boards of directors and provide other consulting and/or business services for other companies during his employment with the Company, with prior written notice given to, and the consent of, the Chief Executive Officer. Executive shall not
be required to relocate his principal residence from Lake Forest, Illinois.” 
  

	2.	Article III, Section 3.1 of the Agreement shall be amended and restated in its entirety as follows: 

“Base Salary. Effective November 1, 2011, Executive shall receive for services to be rendered hereunder an annual base
salary of $222,000.00 (“Amended Base 

 
Annual Salary”), less required deductions and withholdings, payable on the regular payroll dates of the Company.” 

 

	3.	Article III, Section 3.2 of the Agreement shall be amended and restated in its entirety as follows: 

“Annual Bonus. In addition to the Amended Base Annual Salary, during each calendar year Executive will be eligible for an
annual performance bonus, equal to up to 50% of the Amended Base Annual Salary, and which is 100% based upon the achievement of Executive’s performance goals and objectives (“Amended Annual Bonus”). The Compensation
Committee of the Company’s Board shall determine in its sole discretion whether any such bonus has been earned and, if so, the amount of any such bonus. Executive must be an employee in good standing at the time the Compensation Committee
decides to award the Amended Annual Bonus and, if Executive leaves the Company at any time and for any reason prior to such date, he will not be eligible to receive such a bonus or any pro-rata portion of such bonus. Such Amended Annual Bonus shall
be evaluated and paid no later than December 31 of the calendar year following the calendar year to which such Amended Annual Bonus relates.” 
  

	4.	Article III, Section 3.3 of the Agreement shall be amended and restated in its entirety as follows: 

“Vacation and Paid Time Off. Executive shall be entitled to 12 business days of paid vacation each year, accruing on a monthly
basis, and 8 paid holidays each year.” 
  

	5.	Article IV, Section 4.2(a) of the Agreement shall be amended and restated in its entirety as follows: 

“Cash Severance. The Company shall make a single lump sum severance payment to Executive in an amount equal to
Executive’s Amended Base Annual Salary in effect as of the Termination Date, less required tax withholdings and deductions (the “Severance Payment”). The Severance Payment will be paid within sixty (60) days
after the Termination Date, but in no event later than March 15 of the year following the year of termination.” 
  

	6.	Article IV, Section 4.3(a) of the Agreement shall be amended and restated in its entirety as follows: 

“Cash Severance. The Company shall make a single lump sum severance payment to Executive in an amount equal to
Executive’s Amended Base Annual Salary in effect as of the Termination Date, multiplied by one point five (1.5), less required tax withholdings and deductions (the “Change in Control Payment”). The Change in
Control Payment will be paid within sixty (60) days after the Termination Date, but in no event later than March 15 of the year following the year of termination.” 

 

	7.	Article IV, Section 4.4 of the Agreement shall be amended and restated in its entirety as follows: 

“Other Compensation and Benefits. If: (i) the Company terminates Executive’s employment for Cause or as a
result of his death or disability, or (ii) if Executive resigns his employment at any time, except as a result of a 

 
Constructive Termination during the Change in Control Period, then this Agreement shall automatically terminate (except for Article V and Article VII, which shall continue in effect), and upon
such termination, the Company shall have no further obligation to Executive, his spouse or estate, except that the Company shall pay to Executive the amount of his Amended Base Annual Salary, and unused vacation pay, accrued to the date of such
termination.” 
  

	8.	The parties agree that the adjustments in Executive’s duties, responsibilities and level of compensation as detailed in this Second Amendment (the
“Employment Adjustments”), do not constitute and/or trigger a “Constructive Termination” as defined in Section 1.6 of the Agreement, and Executive acknowledges and agrees that he is not entitled to or eligible
for any benefits (severance related or otherwise) as a result of the Employment Adjustments. 

  

	9.	This Second Amendment supersedes and replaces in full the First Amendment. This Second Amendment, along with the Agreement, represents the complete and entire
understanding between the parties regarding the subject matter hereof and supersedes all prior negotiations, representations or agreements, either written or oral, regarding this subject matter. 

 

	10.	This Second Amendment and the rights and obligations of the parties hereunder shall be governed by the laws of the State of California, without regard to the conflicts
of law provisions thereof. 

  

	11.	This Second Amendment may be executed in multiple counterparts, each of which shall be deemed an original, but both of which together shall constitute one and the same
instrument. 

  

	12.	Except for the matters set forth in this Second Amendment, all other terms of the Agreement shall remain unchanged and in full force and effect.

 [Signature Page to Follow] 

 IN WITNESS WHEREOF, the
parties hereto have duly executed this Second Amendment as of the date set forth above. 
  

			
	OREXIGEN THERAPEUTICS, INC.
		
	 By:
	 	 /s/ Michael A. Narachi

	 Name: Michael A. Narachi

	Title: President and Chief Executive Officer

 Accepted and agreed: 
  

	
	 /s/ Mark Booth

	 MARK BOOTH

 [Signature Page to Amendment No. 2 to M. Booth Employment Agreement]Form of Standard Restricted Stock Unit Agreement

 Exhibit 10.5 
 COMERICA INCORPORATED 
 RESTRICTED STOCK UNIT AWARD AGREEMENT

 THIS AGREEMENT (the “Agreement”) between Comerica Incorporated (the “Company”) and NAME (the “Award
Recipient”) is effective as of GRANT DATE (the “Effective Date”). Any undefined terms appearing herein as defined terms shall have the same meaning as they do in the Comerica Incorporated 2006 Long-Term Incentive Plan, as
amended and/or restated from time to time (the “Plan”). The Company will provide a copy of the Plan to the Award Recipient upon request. 
 WITNESSETH: 
 1. Award of Restricted Stock Units. Pursuant to the provisions of the
Plan, the Company hereby awards the Award Recipient, subject to the terms and conditions of the Plan (incorporated herein by reference), and subject further to the terms and conditions in this Agreement, XXX restricted stock units
(“RSUs”) (the “Award”). Each RSU shall represent an unfunded, unsecured right for the Award Recipient to receive one (1) share of the Company’s common stock, par value $5.00 per share (the “Common Stock”), as
described in this Agreement. 
 2. Ownership Rights. The Award Recipient has no voting or other ownership rights in the Company
arising from the award of RSUs under this Agreement. 
 3. Dividends. The Award Recipient shall be credited with dividend equivalents
equal to the dividends the Award Recipient would have received if the Award Recipient had been the owner of a number of shares of Common Stock equal to the number of RSUs credited to the Award Recipient on such dividend payment date (the
“Dividend Equivalent”). Any Dividend Equivalent deriving from a cash dividend shall be converted into additional RSUs based on the Fair Market Value of Common Stock on the dividend payment date (or, if the dividend payment date is not a
day during which the New York Stock Exchange is open for trading (“NYSE Trading Day”), then on the first NYSE Trading Day following the dividend payment date). Subject to Section 11.D. of the Plan, any Dividend Equivalent deriving
from a dividend of shares of Common Stock shall be converted into additional RSUs on a one-for-one basis. The Award Recipient shall continue to be credited with Dividend Equivalents until the Settlement Date (defined below) (or, if applicable, the
forfeiture of the corresponding Award). The Dividend Equivalents so credited shall be subject to the same terms and conditions as the corresponding Award, and they shall vest (or, if applicable, be forfeited) and be settled in the same manner and at
the same time as the corresponding Award, as if they had been granted at the same time as such Award. 
 4. Vesting of Award. The
unvested portion of the Award is subject to forfeiture. Subject to the terms of the Plan and this Agreement, including without limitation, fulfillment of the employment requirements in paragraph 8 below, the Award will vest in accordance with the
following schedule (except in the case of the Award Recipient’s earlier Separation from Service due to death or Disability or an earlier Change of Control of the Company, as set forth in paragraph 6 below): INSERT PERCENTAGE OR FRACTION
of the RSUs covered by this Award shall vest on INSERT VESTING SCHEDULE of the Effective Date of this Award, provided, however, that, any RSU representing a fractional share of Common Stock shall accumulate and vest on the next
following vesting date on which the aggregate of vested fractional shares represents a whole share of Common Stock. 
 5. Settlement.
Once vested, the Award will be settled as follows: 
 In General. Subject to paragraph 11 hereof, the Award will be
settled in Common Stock. Subject to the terms of the Plan, settlement of the vested portion of the Award shall occur on INSERT DATE (or if such date is not a business day, the business day immediately following such date); or, in the case of
(i) the Award Recipient’s Separation from Service due to death or Disability or (ii) a Change of Control (as defined in clause A of Exhibit A of the Plan), settlement of the Award shall occur as of such earlier date set forth in
paragraph 6 hereof (the “Settlement Date”). As soon as practicable (but in no event more than 30 days) following the Settlement Date, the Company shall , issue or cause there to be transferred to the Award Recipient (or, in the case
of the Award Recipient’s death, to the Award Recipient’s designated beneficiary or estate, as applicable or, in the case of the Award Recipient’s Disability, to the Award Recipient’s guardian or legal representative, if
applicable and if permissible under applicable law) a number of whole shares of Common Stock equal to the aggregate number of RSUs (rounded down to a whole number) granted to the Award Recipient under this Agreement (including, without limitation,
the RSUs attributable to Dividend Equivalents) that are vested as of the Settlement Date (the “Settlement Shares”). Notwithstanding the foregoing, if the Award Recipient’s Separation from Service occurs due to Disability, any such
settlement of the Award by reason, of such Separation from Service shall be delayed for six months from the date of the Award Recipient’s Separation from Service if the Participant is considered a “specified employee” for purposes of
Section 409A of the Code (as determined in accordance with the methodology established by the Company as in effect on the date of Separation from Service). 

			
	Restricted Stock Unit Award Agreement	  	Page 2 of 4

 (a) Termination of Rights. Upon the issuance or transfer of Settlement Shares in settlement of the
Award (including, without limitation, the RSUs attributable to Dividend Equivalents), the Award shall be settled in full and the Award Recipient (or his or her designated beneficiary or estate, in the case of death) shall have no further rights with
respect to the Award. 
 (b) Certificates or Book Entry. As of the Settlement Date, the Company shall, at the discretion
of the Committee or its designee, either issue one or more certificates in the Award Recipient’s name for such Settlement Shares or evidence book-entry registration of the Settlement Shares in the Award Recipient’s name (or, in the case of
death, to the Award Recipient’s designated beneficiary, if any). No fractional shares of Common Stock shall be issued in settlement of the RSUs, and any fractional share of Common Stock that would otherwise be Settlement Stock as of the
Settlement Date shall be settled through a cash payment based on the Fair Market Value of a share of Common Stock. 
 (c)
Conditions to Delivery. Notwithstanding any other provision of this Agreement, the Company shall not be required to evidence book-entry registration or issue or deliver any certificate or certificates representing Settlement Shares in the
event the Company reasonably anticipates that such registration, issuance or delivery would violate Federal securities laws or other applicable law; provided that the Company must evidence book-entry registration or issue or deliver said
certificate or certificates at the earliest date at which the Company reasonably anticipates that such registration, issuance or delivery would not cause such violation. 
 (d) Legends. The Settlement Shares shall be subject to such stop transfer orders and other restrictions as the Committee may deem reasonably advisable under the Plan or the rules, regulations, and
other requirements of the Securities and Exchange Commission, any stock exchange upon which such Settlement Shares are listed, any applicable Federal or state laws or the Company’s Certificate of Incorporation and Bylaws, and the Committee may
cause a legend or legends to be put on or otherwise apply to any certificates or book-entry position representing Settlement Shares to make appropriate reference to such restrictions. 
 6. Accelerated Vesting and Settlement on Change of Control and Separation from Service Due to Death and Disability. Notwithstanding anything in this Agreement to the contrary: 

(a) Upon a Change of Control, the Award (including, without limitation, the RSUs attributable to Dividend Equivalents) shall immediately
and fully vest and become nonforfeitable, and such Award shall be settled as soon as practicable (but in no event more than 30 days) following the date of such Change of Control; provided, however, that, in the event that such Change of
Control does not qualify as an event described in Section 409A(a)(2)(A)(v) of the Code and the regulations thereunder, the Award shall not be settled until the first Settlement Date that is also a permissible payment event under
Section 409A of the Code and the regulations thereunder (but shall not be subject to the forfeiture provisions of paragraph 8 hereof following such Change of Control). 
 (b) In the event of the Award Recipient’s Separation from Service due to death or Disability, the Award (including, without limitation, the RSUs attributable to Dividend Equivalents) shall
immediately and fully vest and become nonforfeitable effective as of the date of the Award Recipient’s Separation from Service due to death or Disability, and such Award shall be settled as soon as practicable (but in no event more than 30
days) following the date of such Award Recipient’s Separation from Service due to death or Disability, as applicable. 

(c) The Committee shall have the sole and absolute discretion to determine whether the Award Recipient’s Separation from Service is
by reason of Disability, as defined by the Plan and in accordance with Section 409A of the Code. 
 7. Cancellation of Award. The
Committee has the right to cancel for no consideration all or any portion of the Award in accordance with Section 4 of the Plan if the Committee determines in good faith that the Award Recipient has done any of the following: (i) committed
a felony; (ii) committed fraud; (iii) embezzled; (iv) disclosed confidential information or trade secrets; (v) was terminated for Cause; (vi) engaged in any activity in competition with the business of the Company or any
Subsidiary or Affiliate of the Company; or (vii) engaged in conduct that adversely affected the Company. The Delegate shall have the power and authority to suspend the vesting of or the right to receive Settlement Shares in respect of all or
any portion of the Award if the Delegate makes in good faith the determination described in the preceding sentence. Any such suspension of an Award shall remain in effect until the suspension shall be presented to and acted on by the Committee at
its next meeting. This paragraph 7 shall have no application for the two-year period following a Change of Control of the Company. 

			
	Restricted Stock Unit Award Agreement	  	Page 3 of 4

 8. Employment Requirements. Except as provided in this Agreement, in order to vest in and not forfeit the Award
(or portion thereof, as the case may be), the Award Recipient must remain employed by the Company or one of its Affiliates until the Award (or portion thereof) has vested. If there is a Separation from Service for any reason (other than due to death
or Disability) before a portion of the Award has fully vested, the Award Recipient will forfeit any portion of the Award and corresponding Dividend Equivalents that have not vested as of the date of the Separation from Service unless the Committee
determines otherwise. 
 9. No Right to Continued Employment. Nothing in the Plan or this Agreement shall confer on the Award Recipient
any right to continue in the employment of the Company or its Affiliates for any given period or on any specified terms nor in any way affect the Company’s or its Affiliates’ right to terminate the Award Recipient’s employment without
prior notice at any time for any reason or for no reason. 
 10. Transferability. Unless otherwise determined by the Committee, the RSUs
subject to this Award (including, without limitation, Dividend Equivalents) may not be assigned, alienated, pledged, attached, sold or otherwise transferred or encumbered by the Award Recipient otherwise than by will or by the laws of intestacy, and
any such purported assignment, alienation, pledge, attachment, sale, transfer or encumbrance shall be void and unenforceable against the Company or any Subsidiary or Affiliate; provided, however, that the designation of a beneficiary shall
not constitute an assignment, alienation, pledge, attachment, sale, transfer or encumbrance. 
 11. Adjustment in Award.
The number of shares of Common Stock underlying this Award shall be subject to adjustment in accordance with Section 3.D. of the Plan in the event of a Share Change or Corporate Transaction, and the Committee shall be authorized to make
such other equitable adjustments of the Award or shares of Common Stock issuable pursuant thereto so that the value of the interest of the Award Recipient shall not be decreased by reason of the occurrence of such event. Any such adjustment shall be
deemed conclusive and binding on the Company, the Award Recipient, his or her beneficiaries and all other interested parties.  
 12.
Administration; Amendment. This Award has been made pursuant to a determination by the Committee and/or the Board of Directors of the Company, and the Committee shall have plenary authority to interpret, in its sole and absolute discretion,
any provision of this Agreement and to make any determinations necessary or advisable for the administration of this Agreement. All such interpretations and determinations shall be final and binding on all persons, including the Company, the Award
Recipient, his or her beneficiaries and all other interested parties. Subject to the terms of the Plan, this Agreement may be amended, in whole or in part, at any time by the Committee; provided, however, that no amendment to this Agreement
may adversely affect the Award Recipient’s rights under this Agreement without the Award Recipient’s consent except such an amendment made to cause the Award to comply with applicable law, stock exchange rules or accounting rules.

 13. Binding Nature of Plan. The Award is subject to the Plan. The Award Recipient agrees to be bound by all terms and provisions of
the Plan and related administrative rules and procedures, including, without limitation, terms and provisions and administrative rules and procedures adopted and/or modified after the granting of the Award. In the event any provisions hereof are
inconsistent with those of the Plan, the provisions of the Plan shall control, except to the extent expressly modified herein pursuant to authority granted under the Plan. 
 14. Compliance with Laws and Regulations. The Award and the obligation of the Company to deliver the Settlement Shares subject to the Award are subject to compliance with all applicable laws, rules
and regulations, to receipt of any approvals by any government or regulatory agency as may be required, and to any determinations the Company may make regarding the application of all such laws, rules and regulations. 

15. Notices. Any notice to the Company under this Agreement shall be in writing to the following address or facsimile number: Human
Resources—Executive Compensation, Comerica Incorporated, 1717 Main Street, MC 6515, Dallas, TX 75201; Facsimile Number: 214-462-4430. The Company will address any notice to the Award Recipient to his or her current address according to the
Company’s personnel files. All written notices provided in accordance with this paragraph shall be deemed to be given when (a) delivered to the appropriate address(es) by hand or by a nationally recognized overnight courier service
(costs prepaid); (b) sent by facsimile to the appropriate facsimile number, with confirmation by telephone of transmission receipt; or (c) received by the addressee, if sent by U.S. mail to the appropriate address or by Company
inter-office mail to the appropriate mail code. Either party may designate in writing some other address or facsimile number for notice under this Agreement. 

			
	Restricted Stock Unit Award Agreement	  	Page 4 of 4

 16. Withholding. The Award Recipient authorizes the Company to withhold from his or her compensation, including
the RSUs granted hereunder and the Settlement Shares issuable hereunder, to satisfy any income and employment tax withholding obligations in connection with this Award. No later than the date as of which an amount first becomes includible in the
gross income of the Award Recipient for Federal income tax purposes with respect to any Settlement Shares subject to this Award, the Award Recipient shall pay to the Company, or make arrangements satisfactory to the Company regarding the payment of,
all Federal, state and local income and employment taxes that are required by applicable laws and regulations to be withheld with respect to such amount. The Award Recipient agrees that the Company may delay delivery of the Settlement Shares until
proper payment of such taxes has been made by the Award Recipient. Unless determined otherwise by the Committee, the Award Recipient may satisfy such obligations under this paragraph 16 by any method authorized under Section 9 of the Plan.

 17. Voluntary Participation. Participation in the Plan is voluntary. The value of the Award is an extraordinary item of compensation
outside the scope of the Award Recipient’s employment contract, if any. As such, the Award is not part of normal or expected compensation for purposes of calculating any severance, resignation, redundancy, end of service payments, bonuses,
long-service awards, pension or retirement benefits or similar payments. 
 18. Force and Effect. The various provisions of this
Agreement are severable in their entirety. Any judicial or legal determination of invalidity or unenforceability of any one provision shall have no effect on the continuing force and effect of the remaining provisions. 

19. Successors. This Agreement shall be binding upon and inure to the benefit of the successors of the respective parties. 

20. Applicable Law. The validity, construction and effect of this Agreement and any rules and regulations relating to the Agreement shall be
determined in accordance with the laws of the State of Delaware, unless preempted by federal law, and also in accordance with Internal Revenue Code Section 409A and any interpretive authorities promulgated thereunder. 

IN WITNESS WHEREOF, this Agreement has been executed by an appropriate officer of Comerica Incorporated and by the Award Recipient, both as of the day
and year first above written. 
  

											
	COMERICA INCORPORATED	 		 		 	
						
	By:	 	 	 		 	 	 		 	 
	 Name:
 Title:
	 		 		 	AWARD RECIPIENT	 		 	Employee ID Number

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