Document:

EX-10.26

 Exhibit 10.26 

AKEBIA THERAPEUTICS, INC. 

NON-EMPLOYEE DIRECTOR COMPENSATION PROGRAM 

Non-employee members of the board of directors (the “Board”) of Akebia Therapeutics, Inc. (the
“Company”) shall be eligible to receive cash and equity compensation as set forth in this Non-Employee Director Compensation Program (this “Program”), which is being adopted pursuant to the
Board’s resolutions on February 28, 2014. The cash and equity compensation described in this Program shall be paid or be made, as applicable, automatically and without further action of the Board, to each member of the Board who is not an
employee of the Company or any parent or subsidiary of the Company (each, a “Non-Employee Director”) who may be eligible to receive such cash or equity compensation, unless such Non-Employee Director declines the receipt of
such cash or equity compensation by written notice to the Company. This Program shall remain in effect until it is revised or rescinded by further action of the Board. This Program shall be reviewed by the Board periodically and may be amended,
modified or terminated by the Board at any time in its sole discretion and nothing herein should be construed as a guarantee to any Non-Employee Director of any particular level of cash or equity compensation. The terms and conditions of this
Program shall supersede any prior cash and/or equity compensation arrangements for service as a member of the Board between the Company and any of its Non-Employee Directors. This Program shall become effective on the date of the closing of the
initial public offering of Company common stock (the “Effective Date”). 
 1. Cash Compensation. 

(a) Annual Retainers. Each Non-Employee Director shall be eligible to receive an annual retainer of $35,000 for service on the Board.

 (b) Additional Annual Retainers. In addition to the annual retainer payable pursuant to Section 1(a) above, a Non-Employee
Director shall be eligible to receive the following annual retainers: 
 (i) Chairman of the Board. A Non-Employee Director serving
as Chairman of the Board shall be eligible to receive an additional annual retainer of $20,000 for such service; provided, that, in the event that a Non-Employee Director is one of two concurrently serving Chairmen of the Board, the additional
annual retainer payable to such Non-Employee Director pursuant to this Section 1(b)(i) shall be $10,000. 
 (ii) Audit
Committee. A Non-Employee Director serving as Chairperson of the Audit Committee shall be eligible to receive an additional annual retainer of $15,000 for such service. A Non-Employee Director serving as a member of the Audit Committee (other
than the Chairperson) shall be eligible to receive an additional annual retainer of $7,500 for such service. 
 (iii) Compensation
Committee. A Non-Employee Director serving as Chairperson of the Compensation Committee shall be eligible to receive an additional annual retainer of $10,000 for such service. A Non-Employee Director serving as a member of the Compensation
Committee (other than the Chairperson) shall be eligible to receive an additional annual retainer of $5,000 for such service. 
 (vi)
Nominating and Corporate Governance Committee. A Non-Employee Director serving as Chairperson of the Nominating and Corporate Governance Committee shall be eligible to receive an additional annual retainer of $7,500 for such service. A
Non-Employee Director serving as a member of the Nominating and Corporate Governance Committee (other than the Chairperson) shall be eligible to receive an additional annual retainer of $3,750 for such service. 

 (c) Payment of Retainers. The annual retainers described in Sections 1(a) and 1(b) shall
be earned on a quarterly basis based on a calendar quarter and shall be paid in cash by the Company in arrears not later than the fifteenth day following the end of each calendar quarter. In the event a Non-Employee Director does not serve as a
Non-Employee Director, or in the applicable positions described in Section 1(b), for an entire calendar quarter, the retainer paid to such Non-Employee Director shall be prorated for the portion of such calendar quarter actually served as a
Non-Employee Director, or in such position, as applicable. 
 2. Equity Compensation. Non-Employee Directors shall be granted the
equity awards described below. Each award described below shall be granted under and shall be subject to the terms and provisions of the Company’s 2014 Incentive Plan or any other successor Company equity incentive plan under which awards are
permitted to be made to non-employee directors (the “Equity Plan”) and shall be granted subject to the execution and delivery of a non-qualified stock option award agreement, including attached exhibits, in substantially the
form previously approved by the Board or the Compensation Committee. All applicable terms of the Equity Plan apply to this Program as if fully set forth herein, and all grants of stock options will be granted in accordance with the terms and
conditions of, and hereby are subject in all respects to, the Equity Plan. For the avoidance of doubt, if there is any conflict between the terms of the Equity Plan and this Program, the Plan shall control. 

(a) Initial Awards. Each Non-Employee Director who is initially elected or appointed to the Board after the Effective Date shall be
eligible to receive, on the date of such initial election or appointment, an option to purchase 10,000 shares of the Company’s common stock (subject to adjustment as provided in the Equity Plan). The awards described in this Section 2(a)
shall be referred to as “Initial Awards.” No Non-Employee Director shall be granted more than one Initial Award. 

(b) Subsequent Awards. A Non-Employee Director who (i) has been serving on the Board for at least six months as of the date of any
annual meeting of the Company’s stockholders after the Effective Date and (ii) will continue to serve as a Non-Employee Director immediately following such meeting, shall be automatically granted, on the date of such annual meeting, an
option to purchase 5,000 shares of the Company’s common stock (subject to adjustment as provided in the Equity Plan). The awards described in this Section 2(b) shall be referred to as “Subsequent Awards.” For the
avoidance of doubt, a Non-Employee Director elected for the first time to the Board at an annual meeting of the Company’s stockholders shall only receive an Initial Award in connection with such election, and shall not receive any Subsequent
Award on the date of such meeting as well. 
 (c) Termination of Service of Employee Directors. Members of the Board who are
employees of the Company or any parent or subsidiary of the Company who subsequently terminate their service with the Company and any parent or subsidiary of the Company and remain on the Board will not receive an Initial Award pursuant to
Section 2(a) above, but to the extent that they are otherwise eligible, will be eligible to receive, after termination from service with the Company and any parent or subsidiary of the Company, Subsequent Awards as described in
Section 2(b) above. 
 (d) Terms of Awards Granted to Non-Employee Directors. 

(i) Purchase Price. The per share exercise price of each option granted to a Non-Employee Director shall equal the fair market value
(as determined pursuant to the Equity Plan) of a share of common stock on the date the option is granted. 

  
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 (ii) Vesting. Each Initial Award shall vest and become exercisable in accordance with the
following schedule, subject to the Non-Employee Director remaining in continuous service on the Board through each such vesting date: 25% of the Initial Award shall vest on the one-year anniversary of the date of grant and 75% shall vest ratably on
the first day of each calendar quarter between the one-year anniversary of the date of grant and the fourth anniversary of the date of grant. Each Subsequent Award shall vest and become exercisable in full on the earlier of (A) the first
anniversary of the date of grant or (B) immediately prior to the next annual meeting of the Company’s stockholders after the date of grant, subject to the Non-Employee Director remaining in continuous service on the Board through such
vesting date. In no event shall any portion of an Initial Award or Subsequent Award that is unvested or unexercisable at the time of a Non-Employee Director’s termination of service on the Board become vested and exercisable thereafter. 

(iii) Term. The term of each stock option granted to a Non-Employee Director shall be ten (10) years from the date the option is
granted. 
 3. Reimbursements. The Company shall reimburse each Non-Employee Director for all reasonable, documented, out-of-pocket
travel and other business expenses incurred by such Non-Employee Director in the performance of his or her duties to the Company in accordance with the Company’s applicable expense reimbursement policies and procedures, as in effect from time
to time. To the extent that any reimbursement under the this Program provides for a deferral of compensation under Section 409A of the Internal Revenue Code of 1986, as amended: (a) the amount eligible for reimbursement in one calendar
year may not affect the amount eligible for reimbursement in any other calendar year; (b) the right to reimbursement is not subject to liquidation or exchange for another benefit; and (c) any such reimbursement of an expense must be made
on or before the last day of the calendar year following the calendar year in which the expense was incurred. 
 * * * * * 

  
 3EX-10.27

 Exhibit 10.27 

EXECUTIVE SEVERANCE AGREEMENT 

This EXECUTIVE SEVERANCE AGREEMENT (the “Agreement”) is entered into as of the     day of
                    , 2014 (the “Effective Date”), by and between Akebia Therapeutics, Inc., a Delaware
corporation (“Akebia” or the “Company”), and [FULL LEGAL NAME], a resident of the [State] [Commonwealth] of             (the
“Executive”). 
 WHEREAS, Executive is a valued employee of the Company; and 

WHEREAS, the Company desires to provide certain severance benefits to Executive according to, and contingent upon, the terms and
conditions stated herein (the “Severance Benefits”). 
 NOW, THEREFORE, in consideration of the
foregoing and the mutual promises contained herein, and of other good and valuable consideration, including the compensation to be received by Executive from the Company from time to time, the receipt and sufficiency of which are hereby
acknowledged, the parties hereto, intending legally to be bound, hereby agree as follows: 
 1. Definitions. 

(a) Cause. For purposes of this Agreement, and in each case as determined by the Compensation Committee of the Company’s Board of
Directors (the “Compensation Committee”) in its sole and reasonable discretion, the following will constitute “Cause”: 

(i) indictment or conviction for either any felony offense or any other crime involving dishonesty; 

(ii) participation in any fraud, theft, embezzlement or other misconduct or act of dishonesty involving the Company or any of its
subsidiaries; 
 (iii) intentional damage to any property of the Company or any of its subsidiaries; 

(iv) breach of the holder’s duties of good faith and fair dealing that are owed to the Company or any of its subsidiaries; 

(v) breach or violation of any agreement between Executive and the Company or any of its subsidiaries, including, without limitation, any
employment, confidentiality, non-competition, non-solicitation or assignment of inventions agreement; 
 (vi) conduct which in the good
faith and reasonable determination of the Board of Directors demonstrates gross unfitness to serve; 
 (vii) failure to comply with the code
of conduct of the Company or any of its subsidiaries or any other policies of the Company that have been approved by the Board of Directors or its authorized delegate, 

(viii) insubordination or failure to follow the directions of the Board of Directors or of the Chief Executive Officer or President of the
Company; or 
 (ix) any other conduct by Executive that could be expected to be harmful to the business, interests or reputation of the
Company or any of its subsidiaries. 

  
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 Executive shall have thirty (30) days after notice from the Company to cure the deficiency leading to the
Cause determination (except with respect to Sections 1(a)(i) and 1(a)(ii) above, for which no notice is required) if, in the sole and reasonable discretion of the Compensation Committee, such deficiency is curable. 

(b) Good Reason. For purposes of this Agreement the following will constitute “Good Reason” for Executive to
terminate his/her employment with the Company. For the avoidance of doubt, Executive shall not be considered to have terminated his/her employment for Good Reason unless Executive has (A) reasonably determined in good faith that a Good Reason
condition has occurred; (B) not consented to the occurrence that s/he alleges constitutes Good Reason; (C) given the Company written Notice of Termination for Good Reason not more than sixty (60) days after the initial existence of
the alleged condition giving rise to Good Reason; (D) given the Company at least thirty (30) days after receipt of such notice to cure the alleged deficiency; and (E) terminated his/her employment within sixty (60) days following
the Company’s receipt of such notice. 
 (i) a material reduction in the nature or status of Executive’s responsibilities,
authority, position or duties (unless arising directly or indirectly in connection with a documented and significant performance issue in Executive’s then-current position, as determined by the Compensation Committee in its sole and reasonable
discretion). Notwithstanding the foregoing, neither of the following shall constitute Good Reason: (A) a reassignment of Executive to a position within the Company of substantially equivalent level or status with respect to Executive’s
responsibilities and duties existing immediately prior to such reassignment, or (B) a change in reporting structure; 
 (ii) a material
adverse reduction in the amount of aggregate cash compensation provided to Executive or failure by the Company to pay such compensation, except where such reduction occurs contemporaneously with the implementation of a firm-wide cost-reduction
program affecting comparable executives (a “Reduction Program”); 
 (iii) the failure by the Company to continue in
effect any incentive compensation plan in which Executive participates, unless an equitable alternative compensation arrangement has been provided, except that to the extent that participation in such plans has been reduced or eliminated for all
other eligible executives, in which case the failure to continue Executive in any such plan shall not constitute Good Reason; or 
 (iv)
establishment of the Company’s primary operations in any place beyond a fifty (50) mile radius of Cambridge, Massachusetts; provided, that Executive primarily provides services in Cambridge at the time of such establishment. 

In all respects, the definition of Good Reason shall be interpreted to comply with Code Section 409A, and any successor statute, regulation and guidance
thereto. 
 (c) Change in Control. For purposes of this Agreement, a “Change in Control” means the occurrence
of any of the following events other than in connection with the consummation of an initial public offering of the Company’s securities: 

(i) any “person” (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended) who
is not a shareholder of the Company as of the date of this Agreement or an affiliate thereof is or becomes the “beneficial owner” (as defined in Rule 13d-3 under said Act), directly or indirectly, of securities of the Company
representing 50% or more of the total voting power represented by the Company’s then outstanding voting securities; 

  
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 (ii) a change in the composition of the Board occurring within a two-year period, as a result of
which less than a majority of the directors are Incumbent Directors. “Incumbent Directors” will mean directors who either (A) are directors of the Company as of the date hereof, or (B) are elected, or nominated for election, to
the Board with the affirmative votes of at least a majority of the remaining Incumbent Directors at the time of such election or nomination (but will not include an individual whose election or nomination is in connection with an actual or
threatened proxy contest relating to the election of directors to the Company); 
 (iii) the date of the consummation of a merger, scheme of
arrangement or consolidation of the Company with any other corporation that has been approved by the stockholders of the Company, other than a merger, scheme of arrangement or consolidation which would result in the voting securities of the Company
outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities of the surviving entity) more than fifty percent (50%) of the total voting power represented by the
voting securities of the Company or such surviving entity outstanding immediately after such merger or consolidation; or 
 (iv) the date of
the consummation of the sale or disposition by the Company of all or substantially all the Company’s assets. 
 Notwithstanding the foregoing, a
transaction will not constitute a Change in Control if: (a) its sole purpose is to change the domicile of the Company’s incorporation; or (b) its sole purpose is to create a holding company that will be owned in substantially the same
proportions by the persons who held the Company’s securities immediately before such transaction. 
 In all respects, the definition of Change in
Control shall be interpreted to comply with Code Section 409A, and any successor statute, regulation and guidance thereto. 
 (d)
Notice of Termination. For purposes of this Agreement, a “Notice of Termination” means a notice which, if applicable, sets forth the specific “cause” or “good reason” provision of this
Section 2 and sets forth the effective date of termination. 
 (e) Disability. For purposes of this Agreement,
“Disability” means Executive’s inability by reason of physical or mental impairment to perform his/her job duties for a period exceeding twelve (12) consecutive weeks. 

2. Termination of Agreement. This Agreement will terminate automatically upon (a) Executive’s termination for Cause;
(b) mutual agreement between the Company and Executive; (c) Executive’s death, or (d) Executive’s Disability. Upon termination of this Agreement, Executive or his/her heirs or estate (as applicable) only will be entitled to
payments required by law or agreement and benefits afforded under the Company’s employee benefit plans existing at the time of termination and in which the Executive participates. 

3. Severance Benefits Upon Termination of Executive’s Employment. If Executive’s employment is terminated, then s/he
may be entitled to certain monetary and non-monetary compensation and benefits as set forth below (the “Severance Benefits”): 

(a) Termination by the Company for Cause; Executive’s Death or Disability. If Executive’s employment is terminated by the
Company for Cause or on account of the Executive’s Disability, or if Executive’s employment is terminated due to the Executive’s death, then the Company shall pay Executive all amounts earned or accrued but not paid as of the
effective date of such termination, including (i) Executive’s then-current base salary; (ii) legitimate business expenses incurred by Executive in the performance of his/her duties to the Company in accordance with the Company’s
normal policies and practices; (iii) vacation pay in accordance with applicable law and the Company’s normal policies and practices; and (iv) any earned or accrued bonus or incentive compensation with respect to the calendar year
ended prior to the year in which the termination became effective (collectively, “Accrued Compensation”). 

  
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 (b) Termination by Executive without Good Reason. If Executive terminates his/her
employment without Good Reason, then the Company will pay Executive all Accrued Compensation earned through the date of such resignation. Nothing herein shall prohibit the Company, in its discretion, from effectuating Executive’s resignation
sooner than the date set forth in Executive’s Notice of Termination. 
 (c) Termination by the Company without Cause or by Executive
for Good Reason (No Change in Control). If Executive’s employment is terminated by the Company without Cause or by the Executive for Good Reason where there has not been a Change in Control, and provided that the Executive has satisfied all
conditions precedent as set forth herein, then the Company shall: 
 (i) pay Executive all Accrued Compensation; 

(ii) continue paying Executive’s then-base salary for a period of twelve (12) months payable in accordance with the normal payroll
practices of the Company for its executives generally, with the first such payment to be made on the first payroll date that occurs after the day that is sixty (60) days after the date of termination, retroactive to the date of Executive’s
termination, or such other method of payment as determined by the Company; and 
 (iii) provided that Executive appropriately and timely
completes all required elections, the Company shall reimburse (on a taxable basis) premiums paid by Executive for health and dental insurance premiums (for himself/herself and all eligible dependents) under the Consolidated Omnibus Budget
Reconciliation Act (“COBRA”) at the same amount and to the same extent it would if Executive still was employed by the Company until the earliest of (A) the last day of the month which falls twelve (12) months from
the date of Executive’s termination (or such other period as required by applicable law); (B) the date that Executive and eligible dependents are no longer eligible to receive continuation coverage under COBRA; or (C) the date
Executive becomes eligible to receive health or dental care coverage pursuant to the health or dental care plan of a new employer. 
 In the event that the
Company terminates Executive’s employment without Cause as set forth in this Section 3(c), but the Company determines within one (1) year of such termination that the Company had the right to terminate Executive’s employment for
Cause pursuant to Sections 1(a) and 3(a) above, the Company may terminate the payment of any amounts still owed to Executive pursuant to this Section 3(c). 

(d) Termination by the Company without Cause or by Executive for Good Reason (Change in Control). If Executive’s employment is
terminated by the Company without Cause or by Executive for Good Reason, and provided that such termination occurs within twelve (12) months after the occurrence of such qualifying event giving rise to the Change in Control; then the Company
shall: 
 (i) pay Executive all Accrued Compensation; 

  
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 (ii) continue paying Executive’s then-base salary for a period of twelve (12) months
payable in accordance with the normal payroll practices of the Company for its executives generally, with the first such payment to be made on the first payroll date that occurs after the day that is sixty (60) days after the date of
termination, retroactive to the date of Executive’s termination, or such other method of payment as determined by the Company; 
 (iii)
pay Executive an amount equal to fifty percent (50%) of his/her annual target bonus for the year in which the termination occurs, pro-rated to reflect the month in which the termination occurs, such amount to be payable in a lump-sum on the
date that is the day that is sixty (60) days after the date of termination; and 
 (iv) provided that Executive appropriately and
timely completes all required elections, the Company shall reimburse (on a taxable basis) premiums paid by Executive for health and dental insurance premiums (for himself/herself and all eligible dependents) under COBRA at the same amount and to the
same extent it would if Executive still was employed by the Company until the earliest of (A) the last day of the month which falls twelve (12) months from the date of Executive’s termination (or such other period as required by
applicable law); (B) the date that Executive and eligible dependents are no longer eligible to receive continuation coverage under COBRA; or (C) the date Executive becomes eligible to receive health or dental care coverage pursuant to the
health or dental care plan of a new employer. 
 In the event that the Company terminates Executive’s employment without Cause as set forth in this
Section 3(d), but the Company determines within one (1) year of such termination that the Company had the right to terminate Executive’s employment for Cause pursuant to Sections 1(a) and 3(a) above, the Company may terminate the
payment of any amounts still owed to Executive pursuant to this Section 3(d). 
 (e) Notice of Termination Required. Any
purported termination by the Company or by Executive must be communicated by a written Notice of Termination to the other party. For purposes of this Agreement, no purported termination of employment will be effective without a Notice of
Termination. 
 (f) Timing of Payments. The Accrued Compensation payable to Executive as provided in this Section 3 will be paid
pursuant to applicable state law or within ten (10) business days after the effective date of Executive’s employment termination, whichever period is shorter. Any other compensation provided for in this Section 3 will be paid as set
forth above, subject to Section 9 below. 
 (g) Payroll Taxes and Withholdings. All Severance Benefits provided for in this
Section 3 shall, to the extent required, be subject to ordinary and required payroll taxes, deductions and income tax withholding. 

(h) Reemployment. If Executive becomes reemployed by the Company prior to the end of the period in which Executive is entitled to
receive Severance Benefits, Executive will no longer be entitled to receive such Severance Benefits (except for any Accrued Compensation) as of the effective date of such reemployment. 

(i) Benefit Plans. Executive’s entitlement to any other compensation or benefits upon termination of his/her employment shall be
determined in accordance with the Company’s employee benefit plans and other applicable programs and practices then in effect. 

  
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 4. Conditions Precedent to Receipt of Severance Benefits. Executive shall not be
entitled to receive (or continue to receive) any Severance Benefits, except for Accrued Compensation, and shall not be entitled to any continued vesting of outstanding equity awards pursuant to Section 5(b) below unless: 

(a) Executive executes (prior to the deadline established by the Company), does not revoke and complies with a general release of all claims
against the Company and its officers, directors and employees upon terms and in a form reasonably acceptable to the Company; 
 (b)
Executive executes and complies fully with the restrictive covenants agreement between Executive and the Company regarding assignment of intellectual property, confidentiality and non-disclosure, non-competition and non-solicitation; and 

(c) Executive complies fully with Section 7 hereof. 

5. Accelerated Vesting of Equity.  

(a) Upon a Change in Control. One hundred percent (100%) of Executive’s outstanding unvested options, restricted shares,
restricted stock units or other equity-based awards shall immediately vest upon a Change in Control. The exercisability of stock options (or other awards requiring exercise) shall be extended, to the extent feasible and to the extent consistent with
applicable law and the terms of the Company’s equity plans or programs (each, as in effect from time to time, a “Company Equity Plan” and, together, the “Company Equity Plans”) and the award
agreements issued thereunder, beyond any lockup or similar restrictive period set forth in any documents executed in connection with a Change in Control. The Compensation Committee may determine in its reasonable discretion whether it is advisable
or feasible to amend a Company Equity Plan or Plans and/or any equity agreements issued thereunder between the Company and Executive in order to effect the extended period of exercise contemplated by this Section 5(a). For the avoidance of
doubt, no amendment shall be made by the Compensation Committee in furtherance of this Section 5(a) other than in accordance with Section 409A of Internal Revenue Code of 1986, as amended (the “Code”) and the
regulations and guidance issued thereunder. 
 (b) Upon Termination by the Company without Cause or by Executive for Good Reason.
Executive’s outstanding unvested options, restricted shares, restricted stock units or other equity-based awards shall remain outstanding and continue to vest in accordance with the terms of the applicable equity agreement(s) for the period of
time during which Executive continues to receive Severance Benefits, as if he or she remained employed during such time, in accordance with Section 3(c)(ii) hereof. The Compensation Committee may determine in its reasonable discretion whether
it is advisable or feasible to amend a Company Equity Plan or Plans and/or any equity agreements issued thereunder existing between the Company and Executive in order to effect the extended period of vesting contemplated by this Section 5(b).
For the avoidance of doubt, no amendment shall be made by the Compensation Committee in furtherance of this Section 5(b) other than in accordance with Code Section 409A and the regulations and guidance issued thereunder. 

6. Cooperation. During employment and after the termination of Executive’s employment for any reason, Executive agrees to
cooperate with, and at the request of, the Company in the defense or prosecution of any legal matter or claim in which the Company, any of its affiliates, or any of their past or present employees, agents, officers, directors, attorneys, successors
or assigns, may be or become involved and which arises or arose during Executive’s employment, to the extent such cooperation does not unreasonably interfere with Executive’s personal or professional schedule. Executive will be reimbursed
for any reasonable out-of-pocket expenses incurred thereby. 
 7. Non-Disparagement. Executive agrees that during his/her
employment and for the greater of (A) one (1) year following the termination of his/her employment (regardless of the reason for 

  
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termination) or (B) the period during which Executive receives Severance Benefits hereunder, Executive will not make any statements that are disparaging about or adverse to the business
interests of the Company or which are intended to harm the reputation of the Company including, but not limited to, any statements that disparage any product, service, finances, employees, officers, directors, capabilities or any other aspect of the
Company’s business, products or services. 
 8. Successors and Assigns.  

(a) Assignment by Company. The Company may, without the consent of Executive, assign this Agreement or delegate its obligations
hereunder to any firm, entity, company or person (collectively, a “Person”) in the event that the Company shall hereafter effect a reorganization, consolidate with, or merge into, such Person or transfer all or substantially
all of its properties or assets to such Person. 
 (b) Assignment by Executive. Neither this Agreement nor any right or interest
hereunder will be assignable or transferable by Executive, his/her beneficiaries or legal representatives, except by will or by the laws of descent and distribution. All payments under this Agreement will inure to the benefit of and be enforceable
by Executive’s legal personal representative(s). 
 9. Tax Consequences.  

(a) The Company does not guarantee the tax treatment or tax consequences associated with Severance Benefits received by Executive hereunder.

 (b) Parachute Payments. To the extent consistent with applicable law, the payment of any amounts or the provision of any benefits
under this Agreement including, without limitation, the payment of Severance Benefits pursuant to Section 3 above or the accelerated vesting of equity pursuant to Section 5 above, will be reduced or adjusted to avoid triggering the excise
tax imposed by Section 4999 of the Code, if such adjustment would result in the provision of a greater total benefit, on a net after-tax basis (after taking into account taking any applicable federal, state and local income taxes and the excise
tax imposed by Section 4999), to Executive. 
 (c) Section 409A. The provisions of this Agreement are intended to comply
with the requirements of Code Section 409A or with the conditions for an exemption from such requirements, and shall be construed accordingly. Notwithstanding any provision of this Agreement to the contrary, if at the time of
Executive’s separation from service (as defined below) Executive is a specified employee (as defined below), as determined by the Company, any and all amounts payable in connection with such separation from service that constitute deferred
compensation subject to Code Section 409A, as determined by the Company, and that would otherwise be payable within six (6) months following such separation from service, shall instead be paid on the date that follows the date of such
separation from service by six (6) months (or, if earlier, upon the Executive’s death). For purposes of this Agreement, all references to “termination of employment” and correlative phrases shall be construed to require a
“separation from service” (as defined in Section 1.409A-1(h) of the Treasury regulations after giving effect to the presumptions contained therein), and the term “specified employee” means an individual determined by the
Company to be a specified employee under Treasury regulation Section 1.409A-1(i). 
 Each payment made under this Agreement shall be
treated as a separate payment and the right to a series of installment payments under this Agreement is to be treated as a right to a series of separate payments. 

Any reimbursement for expenses that would constitute nonqualified deferred compensation subject to Section 409A shall be subject to the
following additional rules: (i) no reimbursement of any such expense shall affect Executive’s right to reimbursement of any such expense in any other taxable 

  
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year; (ii) reimbursement of the expense shall be made, if at all, promptly, but not later than the end of the calendar year following the calendar year in which the expense was incurred; and
(iii) the right to reimbursement shall not be subject to liquidation or exchange for any other benefit. 
 10. Notices.
All notices, requests, demands, and other communications called for hereunder will be in writing and will be deemed given (a) on the date of delivery if delivered personally, (b) one (1) day after being sent overnight by a
well-established commercial overnight service, or (c) four (4) days after being mailed by registered or certified mail, return receipt requested, prepaid and addressed to the parties or their successors at the following addresses, or at
such other addresses as the parties may later designate in writing: 
 If to the Company: 

Akebia Therapeutics, Inc. 

Attention: General Counsel 
 245
First Street, Suite 1100 
 Cambridge, Massachusetts 02142 

If to Executive: 
 at the
last residential address known by the Company 
 11. Non-Exclusivity of Rights. Nothing in this Agreement will prevent or
limit Executive’s continuing or future participation in any benefit, bonus, incentive or other plan or program provided by the Company or any of its subsidiaries and for which Executive may qualify, nor will anything herein limit or reduce such
rights as Executive may have under any other agreements with the Company or any of its subsidiaries. Amounts which are vested benefits or which Executive is otherwise entitled to receive under any plan or program of the Company or any of its
subsidiaries will be payable in accordance with such plan or program, except as explicitly modified by this Agreement. 
 12.
Amendments. No provision of this Agreement may be modified, waived or discharged unless such waiver, modification or discharge is agreed to in writing and signed by Executive and the Chief Executive Officer of the Company. 

13. No Waiver. No waiver by either party hereto at any time of any breach by the other party hereto of, or compliance with, any
condition or provision of this Agreement to be performed by such other party will be deemed a waiver of similar or dissimilar provisions or conditions at the same or at any prior or subsequent time. 

14. Governing Law. This Agreement will be governed by and construed and enforced in accordance with the laws of the Commonwealth
of Massachusetts, without giving effect to the conflict of law principles thereof. 
 15. Dispute
Resolution/Jurisdiction/Venue. Any dispute concerning this Agreement shall be heard by a court of competent jurisdiction within Massachusetts. The parties hereby acknowledge that they are subject to the personal jurisdiction of the
Massachusetts courts in any county where the Company has operations or facilities and/or Executive resides. 
 16. Expenses.
To the extent Executive elects to have independent legal counsel review and or negotiate the terms of this Agreement or any release required by this Agreement, Executive shall be solely responsible for all associated costs and fees, including but
not limited to attorneys’ fees. 

  
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 17. Severability. The provisions of this Agreement will be deemed severable and the
invalidity or unenforceability of any provision will not affect the validity or enforceability of the other provisions hereof. 
 18.
Effect on Other Agreements. The terms of this Agreement replace and supersede the terms in all other and prior agreements between Executive and the Company that relate to (i) post-separation severance and other post-separation benefits
and (ii) equity acceleration in connection with a change of control, whether written or oral or express or implied, and no representations, promises, assurances or agreements have been made regarding the subject matter of this Agreement, except such
as has been stated in this Agreement. For the avoidance of doubt, (a) the terms of any existing employment agreement or other agreement between Executive and the Company regarding assignment of intellectual property, confidentiality and
non-disclosure, non-competition and non-solicitation between Executive and the Company shall remain in full force and effect and (b) all other terms in offer letters, employment agreements or any other agreements between Executive and the Company
that do not relate to (1) post-separation severance or other post-separation benefits or (2) equity acceleration in connection with a change of control, will remain in full force and effect. 

THE COMPANY AND EXECUTIVE ACKNOWLEDGE THAT (A) EACH HAS CAREFULLY READ THIS AGREEMENT, (B) EACH UNDERSTANDS ITS TERMS, (C) ALL
UNDERSTANDINGS AND AGREEMENTS BETWEEN THE COMPANY AND EXECUTIVE RELATING TO THE SUBJECTS COVERED IN THIS AGREEMENT ARE CONTAINED IN IT, AND (D) EACH HAS ENTERED INTO THIS AGREEMENT VOLUNTARILY AND NOT IN RELIANCE ON ANY PROMISES OR
REPRESENTATIONS BY THE OTHER, OTHER THAN THOSE CONTAINED IN THIS AGREEMENT ITSELF. 
 IN WITNESS WHEREOF, the Company has caused this
Agreement to be executed by its duly authorized person and Executive has executed this Agreement effective as of the day and year first above written. 
  

									
	EXECUTIVE	 		 	AKEBIA THERAPEUTICS, INC.
					
	 By:
	 	  
	 		 	By:	 	  

		 	[NAME]	 		 		 	John P. Butler
		 		 		 		 	Chief Executive Officer

  
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