Document:

EXHIBIT 10.25

                   OWNERSHIP AND REGISTRATION RIGHTS AGREEMENT

EVCI Career Colleges Incorporated
1 Van Der Donck Street
Yonkers, New York 10701

Ladies and Gentlemen:

      This will confirm our agreement in connection with the purchase by the
undersigned today (each a "Holder" and collectively, the "Holders") of a total
of 500,000 shares (the "Shares") of common stock of EVCI Career Colleges
Incorporated ("EVCI") from the persons identified on the Seller Signature Pages
to the Transfer Instrument dated today, a copy of which has been provided to
EVCI (the "Transfer Instrument").

      Section 1. REPRESENTATIONS AND WARRANTIES

            1.1 Each Holder hereby severally makes to EVCI the representations
and warranties made by the Holder in (a) through (d) of the Transfer Instrument,
as though fully set forth herein.

            1.2 EVCI hereby represents and warrants to each Holder that the
execution, delivery and performance of this Agreement by EVCI has been duly
authorized by all requisite corporate action and will not violate any provision
of law, any order of any court or other agency of government, the articles of
organization or By-laws of EVCI or any provision of any other agreement or
instrument to which it is a party and that this Agreement constitutes the legal,
valid and binding obligation of EVCI, enforceable in accordance with its terms.

      Section 2. SHARES OWNED

            2.1 Each Holder severally represents and warrants to EVCI that the
purchase of Shares by the Holder will not result in the Holder and its
"affiliates," as defined in Rule 144 of the Securities Exchange Act of 1934, as
amended (the "Securities Exchange Act"), being deemed the owner of more than
4.99% of outstanding shares of common stock of EVCI, assuming that there are at
least 12,002,241 shares of Common Stock outstanding immediately after such
purchase. Each Holder agrees that such Holder and its affiliates will not alone
or as a part of a "group," as that term is used in Regulation 13D-G under the
Securities Exchange Act, at any time own more than 4.99% of EVCI's outstanding
common stock unless otherwise authorized by EVCI's board of directors and agreed
to in writing by EVCI.

      Section 3. REGISTRATION RIGHTS

            3.1 Registration. EVCI shall include the resale of the Shares in a
registration statement on Form S-3 or any comparable or successor form or forms
(the "Registration Statement") (provided that if the Company is not entitled to
use Form S-3 or any successor thereto it shall file a registration statement on
Form S-1 or comparable or successor form) filed by it with the Securities and
Exchange Commission ("SEC") by not later than the earlier of the (i) 30th day
following the date of this Agreement, if it has received the written consent to

<PAGE>

do so, in form reasonably satisfactory to EVCI, from all holders of Registrable
Securities at least three business days prior to such initial filing and (ii)
second business day after the Effective Date. The terms Registrable Securities
and Effective Date shall have the meanings as ascribed to them in the
Registration Rights Agreement, a form of which was filed as Exhibit 10.2 to
EVCI's Form 8-K filed with the SEC on March 31, 2004. EVCI's obligation to
include the resale of the shares in the Registration Statement is subject to the
Holder's compliance with Section 3.1(j) with respect to such Holder's Shares.

                  (a) EVCI shall use its best efforts to cause the Registration
Statement to be declared effective within 60 days after its initial filing with
the SEC and to remain effective until the earlier of the date (i) as of which
the Holder may sell all of the Shares without restriction pursuant to Rule
144(k) and (ii) when the Holder shall have sold all of the Shares.

                  (b) EVCI shall prepare and file with the SEC such amendments
and supplements to the Registration Statement and the Prospectus included in the
Registration Statement (the "Prospectus") as may be necessary to keep the
Registration Statement continuously effective, pursuant to Rule 415, for the
period specified in Section 3(a) and comply with the provisions of the
Securities Act of 1933, as amended (the "Securities Act") with respect to the
disposition of all the Shares covered by the Registration Statement in
accordance with the Holders' intended method of disposition set forth in the
Registration Statement for such period; provided, however, notwithstanding the
foregoing provisions of this Section 3(b), EVCI may suspend the use of the
Registration Statement for a period not to exceed 60 days (whether or not
consecutive) in any 12-month period if EVCI's Board of Directors determines in
good faith (after consulting with EVCI's counsel and, if appropriate, its
independent auditors) that because of valid and material business developments
(which, under applicable securities laws, would be required to be disclosed in
an amendment to the Prospectus), including pending mergers or other business
combination transactions, the planned acquisition or divestiture of assets,
pending material corporate developments and similar events, it is advisable to
suspend such use and, prior to or contemporaneously with suspending such use,
EVCI provides each Holder with written notice of such suspension, which notice
need not specify the nature of the event giving rise to such suspension. At the
end of any such suspension period, EVCI shall provide each Holder with written
notice of the termination of such suspension.

                  (c) EVCI shall permit the Holders to review and comment upon
the Registration Statement and, upon all future amendments and supplements
thereto, at least three days prior to their filing with the SEC.

                  (d) EVCI shall furnish to each Holder such number of copies of
the Registration Statement and the Prospectus as Holder reasonably may request
in order to facilitate the public sale or other disposition of such Holder
Shares pursuant to the Prospectus.

                  (e) EVCI shall register or qualify the Shares covered by the
Registration Statement under the securities or "blue sky" laws of such
jurisdictions as the Holder reasonably shall request.

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<PAGE>

                  (f) EVCI shall cause all Shares covered by the Registration
Statement to be eligible for quotation on the Nasdaq Smallcap market or listed
on such other securities exchange (or quoted on the Nasdaq National Market) on
the same terms and conditions as EVCI Common Shares are then quoted (or listed)
provided that EVCI Common Shares are then quoted on the Nasdaq Smallcap market
or listed on such other securities exchange (or quoted on the Nasdaq National
Market).

                  (g) While a Prospectus relating to the Shares is required to
be delivered under the Securities Act, EVCI shall promptly notify each Holder of
the happening of any event of which EVCI has knowledge and as a result of which
the Prospectus, as then in effect, includes an untrue statement of a material
fact or omits to state a material fact required to be stated therein or
necessary to make the statements therein not misleading in light of the
circumstances then existing.

                  (h) Each Holder agrees that, upon receipt of any notice from
EVCI of the happening of any event of the kind specified in Sections 3(b) or
(g), the Holder will immediately discontinue disposition of the Holder's Shares
pursuant to the Prospectus until the Holder's receipt of the copies of the
supplemented or amended Prospectus contemplated by Section 3(b), and, if so
directed by EVCI, the Holder will deliver to EVCI, or alternatively certify that
it has destroyed, all copies, other than permanent file copies then in Holder's
possession, of the most recent Prospectus at the time of receipt of such notice.

                  (i) EVCI shall make available for inspection by each Holder,
and any attorney, accountant or other agent retained by the Holder, all
financial and other records, pertinent corporate documents and properties of
EVCI, and cause EVCI's officers, directors and employees to supply all
information reasonably requested by the Holder or such attorney, accountant or
agent in connection with the Registration Statement, provided appropriate
confidentiality agreements are first received by EVCI.

                  (j) A Holder shall furnish to EVCI in writing such information
with respect to it and the proposed distribution by it, as reasonably shall be
necessary and reasonably requested by EVCI's counsel in writing, in order to
assure compliance with applicable federal and state securities laws.

            3.2 Expenses. All expenses incurred by EVCI in complying with
Section 3.1 including, without limitation, all registration and filing fees,
printing expenses, fees and disbursements of counsel and independent public
accountants for EVCI, fees and expenses (including counsel fees) incurred in
connection with complying with state securities or "blue sky" laws, Nasdaq fees,
fees of transfer agents and registrars, and costs of issuing the Shares, but
excluding any Selling Expenses and fees and disbursements of any counsel or any
accountant or agent of any Holder, are called "Registration Expenses." All
underwriting discounts and selling commissions applicable to the sale of the
Shares are called "Selling Expenses."

      EVCI will pay all Registration Expenses and the Holders will pay all
Selling Expenses.

                                       3
<PAGE>

            3.3 Indemnification.

                  (a) In connection with the registration and sale of a Holder's
Shares pursuant to the Registration Statement, to the fullest extent permitted
by law, EVCI will indemnify and hold harmless the Holder together with the
Holder's officers, directors, members, partners, employees and agents, and each
other person, if any, who controls Holder within the meaning of the Securities
Act (each a "Controlling Person"), against any losses, claims, damages or
liabilities, joint or several, to which the Holder and the Holder's officers,
directors, members, partners, employees and agents, or controlling person may
become subject under the Securities Act or otherwise, insofar as such losses,
claims, damages or liabilities (or actions in respect thereof) arise out of or
are based upon (i) any untrue statement or alleged untrue statement of any
material fact contained in the Registration Statement or the Prospectus or any
amendment or supplement thereof, or (ii) the omission or alleged omission to
state therein a material fact required to be stated therein or necessary to make
the statements therein not misleading, or (iii) any violation or alleged
violation by EVCI of the Securities Act, any state securities law, or any rule
or regulation thereunder relating to the offer or sale of the Shares pursuant to
the Registration Statement (but not the Holder's failure to comply with the
prospectus delivery requirements or other rules and regulations under the
Securities Exchange Act of 1934 relating to the Holder's conduct in offering and
selling the Shares). EVCI will promptly reimburse the Holder and each
Controlling Person for any legal or other expenses reasonably incurred by them
in connection with investigation or defending any such loss, claim, damage,
liability or action; provided, however, that EVCI will not be liable in any such
case if and to the extent that any such loss, claim, damage or liability arises
out of or is based upon an untrue statement or alleged untrue statement or
omission or alleged omission so made in conformity with information furnished by
the Holder or a Controlling Person in writing specifically for use in the
Registration Statement or the Prospectus. Such indemnity shall remain in full
force and effect regardless of any investigation made by or on behalf of the
indemnified party.

                  (b) In connection with the registration and sale of the
Holder's Shares pursuant to the Registration Statement, the Holder will
indemnify and hold harmless EVCI, each person, if any, who controls EVCI within
the meaning of the Securities Act, each officer of EVCI who signs the
Registration Statement, and each director of EVCI, against all losses, claims,
damages or liabilities, joint or several, to which EVCI or such officer,
director, or controlling person may become subject under the Securities Act or
otherwise, insofar as such losses, claims, damages or liabilities (or actions in
respect thereof) arise out of or are based upon (i) any untrue statement or
alleged untrue statement of any material fact contained in the Registration
Statement, the Prospectus contained therein, or any amendment or supplement
thereof, or (ii) the omission or alleged omission to state therein a material
fact required to be stated therein or necessary to make the statements therein
not misleading, and will promptly reimburse EVCI and each such officer,
director, and controlling person for any legal or other expenses reasonably
incurred by them in connection with investigating or defending any such loss,
claim, damage, liability or action; provided, however, that the Holder will have
no liability hereunder unless such loss, claim, damage or liability arises out
of or is based upon an untrue statement or alleged untrue statement or omission
or alleged omission made in reliance upon and in conformity with information
pertaining to the Holder and furnished in writing to EVCI by the Holder
specifically for use in the Registration Statement or the Prospectus; and
provided, further, however, that the liability of the Holder hereunder shall be
limited to the proportion of any such loss, claim, damage, liability or expense

                                       4
<PAGE>

which is equal to the proportion that the public offering price of the Shares
sold by the Holder under the Registration Statement bears to the total public
offering price of all securities sold thereunder, but not in any event to exceed
the net profit received by the Holder from the sale of the Shares covered by the
Registration Statement.

                  (c) Promptly after receipt by an indemnified party hereunder
of notice of the commencement of any action, such indemnified party shall, if a
claim in respect thereof is to be made against the indemnifying party hereunder,
notify the indemnifying party in writing thereof, but the omission so to notify
the indemnifying party shall not relieve it from any liability which it may have
to such indemnified party under this Section 3.3 except and to the extent the
indemnifying party is prejudiced by such omission. In case any such action shall
be brought against any indemnified party and it shall notify the indemnifying
party of the commencement thereof, the indemnifying party shall be entitled to
participate in and, to the extent it shall wish, to assume and undertake the
defense thereof with counsel reasonably satisfactory to such indemnified party,
and, after notice from the indemnifying party to such indemnified party of its
election so to assume and undertake the defense thereof, the indemnifying party
shall not be liable to such indemnified party under this Section 3.3 for any
legal expenses subsequently incurred by such indemnified party in connection
with the defense thereof other than reasonable costs of investigation and of
liaison with counsel so selected; provided, however, that if the defendants in
any such action include both the indemnified party and the indemnifying party
and the indemnified party shall have reasonably concluded that there may be
reasonable defenses available to it which are different from or additional to
those available to the indemnifying party or if the interests of the indemnified
party reasonably may be deemed to conflict with the interests of the
indemnifying party, the indemnified party shall have the right to select a
separate counsel and to assume such legal defenses and otherwise to participate
in the defense of such action, with the expenses and fees of such separate
counsel and other expenses related to such participation to be reimbursed by the
indemnifying party as incurred.

                  (d) In order to provide for just and equitable contribution to
joint liability under the Securities Act in any case in which either (i) a
Holder or any controlling person of the Holder makes a claim for indemnification
pursuant to this Section 3.3 but it is judicially determined (by the entry of a
final judgment or decree by a court of competent jurisdiction as to which time
to appeal or the denial of the last right of appeal has expired) that such
indemnification may not be enforced in such case notwithstanding the fact that
this Section 3.3 provides for indemnification in such case, or (ii) contribution
under the Securities Act may be required on the part of the Holder or any such
controlling person in circumstances for which indemnification is provided under
this Section 3.3, then, and in each such case, EVCI and the Holder will
contribute to the aggregate losses, claims, damages or liabilities to which they
may be subject (after contribution from others) in proportion to their relative
fault provided, however, that, in any such case, (A) the Holder shall not be
required to contribute any amount in excess of the difference between the public
offering price of all the Shares offered by it pursuant to the Registration
Statement and the price paid for the Shares by the Holder; and (B) no person or
entity guilty of fraudulent misrepresentation (within the meaning of Section
11(f) of the Securities Act) will be entitled to contribution from any person or
entity who was not guilty of such fraudulent misrepresentation.

                                       5
<PAGE>

            3.4 Enforcement. EVCI acknowledges that there is no adequate remedy
at law for failure by it to comply with the provisions of this Section 3 and
that such failure would not be adequately compensable in damages, and therefore
agrees that its agreements contained in this Section 3 may be specifically
enforced. In the event that EVCI fails to comply with its obligations and
agreements in this Section 3, then, in addition to any other rights or remedies
a Holder may have at law or in equity, EVCI shall indemnify and hold harmless
the Holder from and against any and all manner of loss which it may incur as a
result of such a failure. In addition, EVCI shall also reimburse the Holder for
any and all reasonable legal fees and expenses incurred by it in enforcing its
rights pursuant to this Section 3, regardless of whether any litigation was
commenced.

      Section 4. MARKET STANDOFF In connection with an underwritten public
offering by EVCI of at least $5 million in total offering price, if any, the
Holder hereby agrees to be subject to a lockup for up to 180 days following the
effective date of EVCI's registration statement filed with the SEC in connection
with the offering as required by the underwriter(s) thereof. During such period,
the Holder agrees not to sell, transfer or hypothecate any securities of EVCI
without the prior written consent of the underwriter(s). This provision is
self-operating but the Holder agrees to execute and furnish directly to, and for
the express benefit of, the underwriter(s) any confirmation requested by the
underwriter(s).

      Section 5. CHOICE OF LAW This Agreement shall be governed by and
interpreted in accordance with the laws of the State of New York without regard
to the principles of conflict of laws.

      Section 6. COUNTERPARTS This Agreement may be executed in two or more
identical counterparts, all of which shall be considered one and the same
instrument and shall become effective when counterparts have been signed by each
party and delivered to the other party.

                            [SIGNATURE PAGE FOLLOWS.]

                                       6
<PAGE>

                                SIGNATURE PAGE TO
                   OWNERSHIP AND REGISTRATION RIGHTS AGREEMENT
                         RELATING TO THE COMMON STOCK OF
                        EVCI CAREER COLLEGES INCORPORATED

Dated:     April 2, 2004            Wellington Trust Company, National
                                    Association Multiple Collective Investment
                                    Funds Trust,
                                    Emerging Companies Portfolio

                                    By:  Wellington Management Company, LLP,
                                    as investment adviser

                                    /s/     Julie A. Jenkins
                                    ------------------------------------
                                    By:  Julie A. Jenkins, Vice President and
                                         Counsel

                                    Wellington Trust Company, National
                                    Association Multiple Common Trust Funds
                                    Trust, Emerging Companies Portfolio

                                    By:  Wellington Management Company, LLP,
                                    as investment advisor

                                    /s/     Julie A. Jenkins
                                    ------------------------------------
                                    By: Julie A. Jenkins, Vice President and
                                        Counsel

                                    The Dow Chemical Company Employees'
                                    Retirement Plan

                                    By:  Wellington Management Company, LLP,
                                    as investment adviser

                                    /s/    Julie A. Jenkins
                                    ------------------------------------
                                    By:  Julie A. Jenkins, Vice President and
                                     Counsel

                                       7
<PAGE>

                                    Howard Hughes Medical Institute

                                    By:  Wellington Management Company, LLP,
                                    as investment adviser

                                    /s/     Julie A. Jenkins
                                    ------------------------------------
                                    By:  Julie A. Jenkins, Vice President and
                                         Counsel

                                    Oregon Investment Council

                                    By:  Wellington Management Company, LLP,
                                    as investment adviser

                                    /s/     Julie A. Jenkins
                                    ------------------------------------
                                    By:  Julie A. Jenkins, Vice President and
                                         Counsel

                                    The Retirement Program Plan for Employees
                                    of Union Carbide

                                    By:   Wellington Management Company, LLP,
                                    as investment adviser

                                    /s/     Julie A. Jenkins
                                    ------------------------------------
                                    By:   Julie A. Jenkins, Vice President
                                   and Counsel

AGREED:

EVCI CAREER COLLEGES INCORPORATED

By:  /s/  Dr. Arol I. Buntzman
     -------------------------------------
        Dr. Arol I. Buntzman
        Chairman

                                       8Exhibit 4.08

                          REGISTRATION RIGHTS AGREEMENT

         This REGISTRATION RIGHTS AGREEMENT (this "Agreement"), dated and
effective this 4th day of June, 2003, by and among CYTOMEDIX, INC., a Delaware
corporation, (the "Company"), and the undersigned together with any assignee or
transferee of all of their respective registration rights hereunder (the
"Investor").

         WHEREAS:

         A. In connection with the Subscription Agreement by and among the
parties hereto of even date herewith (the "Subscription Agreement"), the Company
has agreed, upon the terms and subject to the conditions contained therein, to
issue and sell to the Investor shares of the Company's common stock (the Common
Stock); and

         B. To induce the Investors to execute and deliver the Subscription
Agreement, the Company has agreed to provide certain registration rights under
the Securities Act of 1933, as amended, and the rules and regulations
thereunder, or any similar successor statute (collectively, the "1933 Act"), and
applicable state securities laws;

         NOW, THEREFORE, in consideration of the premises and the mutual
covenants contained herein and other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the Company and each
of the Investors hereby agree as follows:

                  1.       DEFINITIONS.

                  As used in this Agreement, the following terms shall have the
following meanings:

                  (a) "Confidential Offering Memorandum" means the Confidential
Offering Memorandum of the Company dated June 4, 2003;

                  (b) "Effective Date" means the effective date of this
Agreement;

                  (c) "Investors" means the initial investors and any transferee
or assignee who agrees to become bound by the provisions of this Agreement;

                  (d) "Register," "registered," and "registration" refer to a
registration effected by preparing and filing a Registration Statement or
Statements in compliance with the 1933 Act and pursuant to Rule 415 under the
1933 Act or any successor rule providing for offering securities on a continuous
basis ("Rule 415"), and the declaration or ordering of effectiveness of such
Registration Statement by the United States Securities and Exchange Commission
(the "SEC");

                  (e) "Registrable Securities" means the shares of Common Stock
offered, sold and issued pursuant to the Confidential Offering Memorandum and
any shares of Common Stock issued or issuable as a dividend on or in exchange
for or otherwise with respect to any of the foregoing, provided, that any shares
of Common Stock which have been sold pursuant to a Registration Statement or
which may be sold without registration or restriction (including volume
limitations) shall cease to be Registerable Securities hereunder; and

<PAGE>

                  (f) "Registration Statement" means a registration statement of
the Company under the 1933 Securities Act.

         2. PIGGYBACK REGISTRATION.

                  (a) Following the Effective Date, each time that the Company
proposes to register a public offering solely of its Common Stock, other than
pursuant to a Registration Statement on Form S-4 or Form S-8 or similar or
successor forms (collectively, Excluded Forms), the Company shall promptly give
written notice of such proposed registration to all holders of Registerable
Securities, which shall offer such holders the right to request inclusion of any
Registrable Securities in the proposed Registration Statement.

                  (b) Each holder of Registrable Securities shall have ten (10)
days or such longer period as shall be set forth in the notice from the receipt
of such notice to deliver to the Company a written request specifying the number
of shares of Registrable Securities such holder intends to sell and the holder's
intended plan of disposition.

                  (c) In the event that the proposed Registration Statement by
the Company is, in whole or in part, an underwritten public offering of
securities of the Company, any request under Section 2(b) may specify that the
Registrable Securities be included in the underwriting on the same terms and
conditions as the shares of Common Stock, if any, otherwise being sold through
underwriters under such Registration Statement.

                  (d) Upon receipt of a written request pursuant to Section
2(b), the Company shall promptly use its best efforts to cause all such
Registrable Securities to be registered, to the extent required to permit sale
or disposition as set forth in the written request.

                  (e) Notwithstanding the foregoing, if the managing underwriter
of an underwritten public offering, determines and advises in writing that the
inclusion of all Registrable Securities proposed to be included in the
underwritten public offering, together with any other issued and outstanding
shares of Common Stock proposed to be included therein by holders other than the
holders of Registrable Securities (such other shares hereinafter collectively
referred to as the Other Shares), would interfere with the successful marketing
of the securities proposed to be included in the underwritten public offering,
then the number of such shares to be included in such underwritten public
offering shall be reduced, and shares shall be excluded from such underwritten
public offering in a number deemed necessary by such managing underwriter, first
by excluding shares held by the directors, officers, employees and founders of
the company, and then, to the extent necessary, by excluding Registrable
Securities participating in such underwritten public offering, pro rata based on
the number of shares of Registrable Securities each such holder proposed to
include.

<PAGE>

                  (f) All shares of Common Stock that are not included in the
underwritten public offering shall be withheld from the market by the holders
thereof for a period, not to exceed twelve (12) months following a public
offering, that the managing underwriter reasonably determines as necessary in
order to effect the underwritten public offering. The holders of such Shares
shall execute such documentation as the managing underwriter reasonably requests
to evidence this lock-up.

         3. OBLIGATIONS OF THE COMPANY.

         If and whenever the Company is under an obligation pursuant to the
provisions of Section 2 to use its best efforts to affect the registration of
any Registrable Securities, the Company shall have the following obligations:

                  (a) The Company shall prepare and file with the SEC a
Registration Statement with respect to such Registrable Securities, and
thereafter use its best efforts to cause such Registration Statement relating to
Registrable Securities to become effective as soon as possible after such
filing. The Company shall keep the Registration Statement effective pursuant to
Rule 415 at all times until such date as is the earlier of (i) the date on which
all of the Registrable Securities have been sold and (ii) the date on which the
Registrable Securities (in the opinion of counsel to the Company) may be
immediately sold to the public without registration or restriction (including
without limitation as to volume by each holder thereof) under the 1933 Act (the
"Registration Period"). The Registration Statement (including any amendments or
supplements thereto and prospectuses contained therein) shall not contain any
untrue statement of a material fact or omit to state a material fact required to
be stated therein, or necessary to make the statements therein, in light of the
circumstances, under which they were made, not misleading.

                  (b) The Company shall prepare and file with the SEC such
amendments (including post-effective amendments) and supplements to the
Registration Statements and the prospectus used in connection with the
Registration Statements as may be necessary to keep the Registration Statements
effective at all times during the Registration Period, and, during such period,
comply with the provisions of the 1933 Act with respect to the disposition of
all Registrable Securities of the Company covered by the Registration Statements
until such time as all such Registrable Securities have been disposed of in
accordance with the intended methods of disposition by the seller or sellers
thereof as set forth in the Registration Statements.

                  (c) The Company shall furnish to each Investor whose
Registrable Securities are included in a Registration Statement such number of
copies of a prospectus, including a preliminary prospectus, and all amendments
and supplements thereto and such other documents as such Investor may reasonably
request in order to facilitate the disposition of the Registrable Securities
owned by such Investor in accordance with the Registration Statement.

                  (d) The Company shall use its best efforts to register or
qualify the Registrable Securities under such other securities or blue sky laws
of such jurisdictions as the Investor reasonably shall request. However, the
Company shall not be obligated, by reason thereof, to qualify as a foreign
corporation or file any general consent to service of process under the laws of
any such jurisdiction or subject itself to taxation as doing business in any
such jurisdiction.

<PAGE>

                  (e) The Company will promptly respond to any and all comments
received from the SEC (which comments shall promptly be made available to the
Investors upon request, unless they relate to information for which the Company
has sought confidential treatment), with a view towards causing the Registration
Statement or any amendment thereto to be declared effective by the SEC as soon
as practicable, shall promptly file an acceleration request as soon as
practicable following the resolution or clearance of all SEC comments or, if
applicable, following notification by the SEC that any such Registration
Statement or any amendment thereto will not be subject to review and shall
promptly file with the SEC a final prospectus as soon as practicable following
receipt by the Company from the SEC of an order declaring the Registration
Statement effective.

                  (f) The Company may enter into an underwriting agreement which
shall be similar in form, scope and substance as is customary in underwritten
offerings, and may take all such other actions in connection therewith in order
to expedite or facilitate the disposition of the Registrable Securities. The
Company shall select the underwriter or underwriters to be engaged and shall
designate the representative, if any, of the underwriters so engaged. In such
connection, the Company shall make such representations and warranties to the
underwriters with respect to the business of the Company, the Registration
Statement, the prospectus and the documents, if any, incorporated or deemed to
be incorporated by reference in the Registration Statement, in each case in
form, substance and scope as are customarily made by issuers to underwriters in
underwritten (initial or secondary, as applicable) offerings and confirm the
same if and when requested. The Company shall also obtain opinions of counsel to
the Company and updates thereof, which counsel and opinions (in form, scope and
substance) shall be reasonably satisfactory to the representative of the
underwriters.

                  (g) The Company shall use its best efforts to prevent the
issuance of any stop order or other suspension of effectiveness of any
Registration Statement, and, if such an order is issued, to obtain the
withdrawal of such order at the earliest possible moment and to notify each
Investor who holds Registrable Securities being sold (or, in the event of an
underwritten offering, the managing underwriters) of the issuance of such order
and the resolution thereof.

                  (h) The Company shall make available for inspection by any
Investor or Investor's counsel, or any underwriter participating in any
disposition pursuant to a Registration Statement (collectively, the
"Inspectors") all pertinent financial and other records, and pertinent corporate
documents and properties of the Company (collectively, the "Records"), as shall
be reasonably deemed necessary by each Inspector to enable each Inspector to
exercise its due diligence responsibility, and cause the Company's officers,
directors and employees to supply all information which any Inspector may
reasonably request for purposes of such due diligence; provided, however, that
each Inspector shall hold in confidence and shall not make any disclosure
(except to an Investor) of any Record or other information which the Company
determines in good faith to be confidential, and of which determination the
Inspectors are so notified, unless (a) the disclosure of such Records is
necessary to avoid or correct a misstatement or omission in any Registration
Statement, (b) the release of such Records is ordered pursuant to a subpoena or
other order from a court or government body of competent jurisdiction, or (c)
the information in such Records has been made generally available to the public
other than by disclosure in violation of this or any other agreement. The
Company shall not be required to disclose any confidential information in such
Records to any Inspector until and unless such Inspector shall have entered into
confidentiality agreements (in form and substance satisfactory to the Company).
Each Inspector agrees that it shall, upon learning that disclosure of such
Records is sought in or by a court or governmental body of competent
jurisdiction or through other means, give prompt notice to the Company and allow
the Company, at its expense, to undertake appropriate action to prevent
disclosure of, or to obtain a protective order for, the Records deemed
confidential. Nothing herein (or in any other confidentiality agreement between
the Company and any Investor) shall be deemed to limit the Investor's ability to
sell Registrable Securities in a manner which is otherwise consistent with
applicable laws and regulations.

<PAGE>

                  (i) The Company shall as soon as practicable use its best
efforts to (i) cause all the Registrable Securities covered by the Registration
Statement to be listed on each national securities exchange on which securities
of the same class or series issued by the Company are then listed, if any, if
the listing of such Registrable Securities is then permitted under the rules of
such exchange, or (ii) to the extent the securities of the same class or series
are not then listed on a national securities exchange, secure the designation
and quotation, of all the Registrable Securities covered by the Registration
Statement on NASDAQ or, if not eligible for NASDAQ, on NASDAQ SmallCap or, if
not eligible for NASDAQ or NASDAQ SmallCap, on the Over-The-Counter Bulletin
Board ("OTCBB") and, without limiting the generality of the foregoing, to
arrange for at least two market makers to register with the National Association
of Securities Dealers, Inc. ("NASD") as such with respect to such Registrable
Securities.

                  (j) The Company shall provide a transfer agent and registrar,
which may be a single entity, for the Registrable Securities not later than the
effective date of the Registration Statement.

                  (k) The Company shall cooperate with the Investors who hold
Registrable Securities being offered and the managing underwriter or
underwriters, if any, to facilitate the timely preparation and delivery of
certificates (not bearing any restrictive legends) representing shares of Common
Stock and enable such certificates to be in such denominations or amounts, as
the case may be, as the managing underwriter or underwriters, if any, or the
Investors may reasonably request and registered in such names as the managing
underwriter or underwriters, if any, or the Investors may request. The Company
shall deliver, and shall cause legal counsel selected by the Company to deliver,
to the transfer agent for the Registrable Securities (with copies to the
Investors whose Registrable Securities are included in such Registration
Statement) an instruction that certain shares have been registered and may be
transferred.

         4. OBLIGATIONS OF THE INVESTORS.

         In connection with the registration of the Registrable Securities, the
Investors shall have the following obligations:

<PAGE>

                  (a) It shall be a condition precedent to the obligations of
the Company to complete the registration pursuant to this Agreement with respect
to the Registrable Securities of a particular Investor that such Investor shall
furnish to the Company such information regarding itself, the Registrable
Securities held by it, and the intended method of disposition of the Registrable
Securities held by it as shall be reasonably required to effect the registration
of such Registrable Securities and shall execute such documents in connection
with such registration as the Company may reasonably request. At least fifteen
(15) business days prior to the first anticipated filing date of the
Registration Statement, the Company shall notify each Investor of the
information the Company requires from each such Investor.

                  (b) Each Investor, by such Investor's written request for
inclusion of its Registrable Securities in a Registration Statement, agrees to
cooperate with the Company as reasonably requested by the Company in connection
with the preparation and filing of the Registration Statements hereunder.

                  (c) In the event the Company decides to engage the services of
an underwriter, each Investor by requesting inclusion of its Registrable
Securities in a Registration Statement agrees to enter into and perform such
Investor's obligations under an underwriting agreement, in usual and customary
form, including, without limitation, customary indemnification and contribution
obligations, with the managing underwriter of such offering and take such other
actions as are reasonably required in order to expedite or facilitate the
disposition of the Registrable Securities.

                  (d) Each Investor agrees that, upon receipt of any notice from
the Company of the happening of any event described in Section 3(g), such
Investor will immediately discontinue disposition of Registrable Securities
pursuant to the Registration Statement covering such Registrable Securities
until such Investor's receipt of the copies of the supplemented or amended
prospectus. If so directed by the Company, such Investor shall deliver to the
Company (at the expense of the Company) or destroy (and deliver to the Company a
certificate of destruction) all copies in such Investor's possession, of the
prospectus covering such Registrable Securities current at the time of receipt
of such notice.

                  (e) No Investor may participate in any underwritten
registration hereunder unless such Investor (i) agrees to sell such Investor's
Registrable Securities on the basis provided in any underwriting arrangements in
usual and customary form entered into by the Company, (ii) completes and
executes all questionnaires, powers of attorney, indemnities, underwriting
agreements and other documents reasonably required under the terms of such
underwriting arrangements, and (iii) agrees to pay its pro rata share of all
underwriting discounts and commissions and any expenses in excess of those
payable by the Company pursuant to Section 5 below.

<PAGE>

         5. EXPENSES OF REGISTRATION.

         All reasonable expenses (other than underwriting discounts and
commissions and stock transfer taxes, if any, and such fees for counsel,
printing, registration and other fees as state securities officials may require
that holders of shares pay) including, without limitation, all registration,
listing and qualification fees, printers and accounting fees, the fees and
disbursements of counsel for the Company, shall be paid by the Company.

         6. INDEMNIFICATION.

                  (a) To the extent permitted by law, the Company will
indemnify, hold harmless and defend (i) each Investor who holds such Registrable
Securities, (ii) the directors, officers, partners and each person who controls
any Investor within the meaning of the 1933 Act or the Securities Exchange Act
of 1934, as amended (the "1934 Act"), if any, (iii) any underwriter (as defined
in the 1933 Act) for the Investors, and (iv) the directors, officers, partners,
employees and each person who controls any such underwriter within the meaning
of the 1933 Act or the 1934 Act, if any (each, an "Indemnified Person"), against
any joint or several losses, claims, damages, liabilities or expenses
(collectively, together with actions, proceedings or inquiries by any regulatory
or self-regulatory organization, whether commenced or threatened, in respect
thereof, "Claims") to which any of them may become subject insofar as such
Claims arise out of or are based upon: (i) any untrue statement or alleged
untrue statement of a material fact in a Registration Statement or the omission
or alleged omission to state therein a material fact required to be stated or
necessary to make the statements therein, in light of the circumstances under
which they were made, not misleading; (ii) any untrue statement or alleged
untrue statement of a material fact contained in any preliminary prospectus if
used prior to the effective date of such Registration Statement, or contained in
the final prospectus (as amended or supplemented, if the Company files any
amendment thereof or supplement thereto with the SEC) or the omission or alleged
omission to state therein any material fact necessary to make the statements
made therein, in light of the circumstances under which the statements therein
were made, not misleading; or (iii) any violation or alleged violation by the
Company of the 1933 Act, the 1934 Act, any other law, including, without
limitation, any state securities law, or any rule or regulation thereunder
relating to the offer or sale of the Registrable Securities (the matters in the
foregoing clauses (i) through (iii) being, collectively, "Violations"). The
Company shall reimburse the Indemnified Person for any reasonable legal fees or
other reasonable expenses incurred by them in connection with investigating or
defending any such Claim, subject to section 6(c). Notwithstanding anything to
the contrary contained herein, the indemnification agreement contained in this
Section 6(a): (i) shall not apply to a Claim arising out of or based upon a
Violation which occurs in reliance upon and in conformity with information
furnished in writing to the Company by any Indemnified Person or underwriter for
such Indemnified Person expressly for use in connection with the preparation of
such Registration Statement or any such amendment thereof or supplement thereto,
if such prospectus was timely made available by the Company pursuant to Section
3(c) hereof (ii) shall not apply to amounts paid in settlement of any Claim if
such settlement is effected without the prior written consent of the Company,
which consent shall not be unreasonably withheld; (iii) with respect to any
preliminary prospectus, shall not inure to the benefit of any Indemnified
Person, if the untrue statement or omission of material fact contained in the
preliminary prospectus was corrected on a timely basis in the prospectus, as
then amended or supplemented, and such corrected prospectus was timely made
available by the Company and the Indemnified Person was promptly advised in
writing not to use the incorrect prospectus prior to the use giving rise to a
Violation and such Indemnified Person, notwithstanding such advice, used it, and
(iv) in the case of gross negligence or willful misconduct by such Investor.

<PAGE>

                  (b) In connection with any Registration Statement in which an
Investor is participating, each such Investor agrees to indemnify, hold harmless
and defend, to the same extent and in the same manner set forth in Section 6(a),
the Company, each of its directors, each of its officers who signs the
Registration Statement, each person, if any, who controls the Company within the
meaning of the 1933 Act or the 1934 Act, any underwriter and any other
stockholder selling securities pursuant to the Registration Statement or any of
its directors or officers or any person who controls such stockholder or
underwriter within the meaning of the 1933 Act or the 1934 Act (collectively and
together with an Indemnified Person, an "Indemnified Party"), against any Claim
to which any of them may become subject, under the 1933 Act, the 1934 Act or
otherwise, insofar as such Claim arises out of or is based upon any Violation by
such Investor, in each case to the extent (and only to the extent) that such
Violation occurs in reliance upon and in conformity with written information
furnished to the Company by such Investor expressly for use in connection with
such Registration Statement (or prospectus forming a part thereof); and subject
to Section 6(c) such Investor will reimburse any legal or other expenses
incurred by them in connection with investigating or defending any such Claim;
provided, however, that the indemnity agreement contained in this Section 6(b)
shall not apply (i) to amounts paid in settlement of any Claim if such
settlement is effected without the prior written consent of such Investor, which
consent shall not be unreasonably withheld and (ii) in the case of gross
negligence or willful misconduct by the Company; provided, further, however,
that the Investor shall be liable under this Agreement (including this Section
6(b) and Section 7) for only that amount as does not exceed the net proceeds to
such Investor as a result of the sale of Registrable Securities pursuant to such
Registration Statement. Such indemnity shall remain in full force and effect
regardless of any investigation made by or on behalf of such Indemnified Party
and shall survive the transfer of the Registrable Securities by the Investors
pursuant to Section 9. Notwithstanding anything to the contrary contained
herein, the indemnification agreement contained in this Section 6(b) with
respect to any preliminary prospectus shall not inure to the benefit of any
Indemnified Party if the untrue statement or omission of material fact contained
in the preliminary prospectus was corrected on a timely basis in the prospectus,
as then amended or supplemented.

                  (c) Promptly after receipt by an Indemnified Person or
Indemnified Party under this Section 6 of notice of the commencement of any
action (including any governmental action), such Indemnified Person or
Indemnified Party shall, if a Claim in respect thereof is to be made against any
indemnifying party under this Section 6, deliver to the indemnifying party a
written notice of the commencement thereof, and the indemnifying party shall
have the right to participate in, and, to the extent the indemnifying party so
desires, jointly with any other indemnifying party similarly noticed, to assume
control of the defense thereof with counsel mutually satisfactory to the
indemnifying party and the Indemnified Person or the Indemnified Party, as the
case may be; provided, however, that an Indemnified Person or lndemnified Party
shall have the right to retain its own counsel with the fees and expenses to be
paid by the indemnifying party, if, in the reasonable opinion of counsel
retained by the indemnifying party, the representation by such counsel of the
Indemnified Person or Indemnified Party and the indemnifying party would be
inappropriate due to actual or potential differing interests between such
Indemnified Person or Indemnified Party and any other party represented by such
counsel in such proceeding. The indemnifying party shall pay for only one
separate legal counsel for the Indemnified Persons or the Indemnified Parties,
as applicable, and such legal counsel shall be selected by Investors holding at
least seventy-five percent (75%) of the Registrable Securities included in the
Registration Statement to which the Claim relates, if the Investors are entitled
to indemnification hereunder, or the Company, if the Company is entitled to
indemnification hereunder, as applicable. The failure to deliver written notice
to the indemnifying party within a reasonable time of the commencement of any
such action shall not relieve such indemnifying party of any liability to the
Indemnified Person or Indemnified Party under this Section 6, except to the
extent that the indemnifying party is actually prejudiced in its ability to
defend such action. The indemnification required by this Section 6 shall be made
by periodic payments of the amount thereof during the course of the
investigation or defense, as such expense, loss, damage or liability is incurred
and is due and payable.

<PAGE>

         7.       CONTRIBUTION.

         To the extent any indemnification by an indemnifying party is
prohibited or limited by law, the indemnifying party agrees to make the maximum
contribution with respect to any amounts for which it would otherwise be liable
under Section 6 to the fullest extent permitted by law; provided, however, that
(i) no contribution shall be made under circumstances where the maker would not
have been liable for indemnification under the fault standards set forth in
Section 6, (ii) no seller of Registrable Securities guilty of fraudulent
misrepresentation (within the meaning of Section 11(f) of the 1933 Act) shall be
entitled to contribution from any seller of Registrable Securities who was not
guilty of such fraudulent misrepresentation, and (iii) contribution (together
with any indemnification or other obligations under this Agreement) by any
seller of Registrable Securities shall be limited in amount to the net amount of
proceeds received by such seller from the sale of such Registrable Securities.

         8.       REPORTS UNDER THE 1934 ACT.

         With a view to making available to the Investors the benefits of Rule
144 promulgated under the 1933 Act or any other similar rule or regulation of
the SEC that may at any time permit the investors to sell Registrable Securities
to the public without registration ("Rule 144"), the Company will use its best
efforts to:

                  (a) make and keep public information available, as those terms
are understood and defined in Rule 144;

                  (b) file with the SEC in a timely manner all reports and other
documents required of the Company under the 1933 Act and the 1934 Act so long as
the Company remains subject to such requirements and the filing of such reports
and other documents is required for the applicable provisions of Rule 144; and

<PAGE>

                  (c) furnish to each Investor so long as such Investor owns
Registrable Securities, promptly upon request, (i) a written statement by the
Company that it has complied with the reporting requirements of Rule 144, the
1933 Act and the 1934 Act, (ii) a copy of the most recent annual or quarterly
report of the Company and such other reports and documents so filed by the
Company, and (iii) such other information as may be reasonably requested to
permit the Investors to sell such securities pursuant to Rule 144 without
registration.

         9.       AMENDMENT OF REGISTRATION RIGHTS.

         Provisions of this Agreement may be amended and the observance thereof
may be waived (either generally or in a particular instance and either
retroactively or prospectively), only with written consent of the Company and
Investors who hold at least seventy-five percent (75%) of the Registrable
Securities. Any amendment or waiver effected in accordance with this Section 9
shall be binding upon each Investor and the Company.

         10.      MISCELLANEOUS.

                  (a) A person or entity is deemed to be a holder of Registrable
Securities whenever such person or entity is the owner of record of such
Registrable Securities. If the Company receives conflicting instructions,
notices or elections from two or more persons or entities with respect to the
same Registrable Securities, the Company shall act upon the basis of
instructions, notice or election received from the registered owner of such
Registrable Securities.

                  (b) Any notices required or permitted to be given under the
terms hereof shall be sent by certified or registered mail (return receipt
requested), delivered personally or by courier (including a recognized overnight
delivery service), or by facsimile and shall be effective five days after being
placed in the mail, if mailed by regular United States mail, or upon receipt, if
delivered personally, by courier (including a recognized overnight delivery
service), or by facsimile, in each case addressed to a party. The addresses for
such communications shall be as follows unless otherwise notified:

                           If to the Company:

                           Cytomedix, Inc.
                           Attn:  Kent Smith, Chief Executive Officer
                           1523 S. Bowman Rd, Suite A
                           Little Rock, AR  72211

                           With copy to:

                           Williams & Anderson LLP
                           Attn:  Peter Kumpe
                           111 Center Street, 22nd Floor
                           Little Rock, Arkansas 72201

<PAGE>

If to an Investor: to the address set forth immediately below such Investor's
name on the signature pages to the Subscription Agreement.

                  (c) Failure of any party to exercise any right or remedy under
this Agreement or otherwise, or delay by a party in exercising such right or
remedy, shall not operate as a waiver thereof.

                  (d) THIS AGREEMENT SHALL BE ENFORCED, GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF ARKANSAS, WITHOUT REGARD
TO THE PRINCIPLES OF CONFLICT OF LAWS. THE PARTIES HERETO HEREBY SUBMIT TO THE
EXCLUSIVE JURISDICTION OF THE UNITED STATES FEDERAL COURTS LOCATED IN LITTLE
ROCK, ARKANSAS WITH RESPECT TO ANY DISPUTE ARISING UNDER THIS AGREEMENT, THE
AGREEMENTS ENTERED INTO IN CONNECTION HEREWITH OR THE TRANSACTIONS CONTEMPLATED
HEREBY OR THEREBY. BOTH PARTIES IRREVOCABLY WAIVE THE DEFENSE OF AN INCONVENIENT
FORUM TO THE MAINTENANCE OF SUCH SUIT OR PROCEEDING. BOTH PARTIES FURTHER AGREE
THAT SERVICE OF PROCESS UPON A PARTY MAILED BY FIRST CLASS MAIL SHALL BE DEEMED
IN EVERY RESPECT EFFECTIVE SERVICE OF PROCESS UPON THE PARTY IN ANY SUCH SUIT OR
PROCEEDING. NOTHING HEREIN SHALL AFFECT ANY PARTY'S RIGHT TO SERVE PROCESS IN
ANY OTHER MANNER PERMITTED BY LAW. ALL PARTIES AGREE THAT A FINAL NON-APPEALABLE
JUDGMENT IN ANY SUCH SUIT OR PROCEEDING SHALL BE CONCLUSIVE AND MAY BE ENFORCED
IN OTHER JURISDICTIONS BY SUIT ON SUCH JUDGMENT OR IN ANY OTHER LAWFUL MANNER.
THE PARTY WHICH DOES NOT PREVAIL IN ANY DISPUTE ARISING UNDER THIS AGREEMENT
SHALL BE RESPONSIBLE FOR ALL FEES AND EXPENSES, INCLUDING ATTORNEYS FEES,
INCURRED BY THE PREVAILING PARTY IN CONNECTION WITH SUCH DISPUTE.

                  (e) In the event that any provision of this Agreement is
invalid or unenforceable under any applicable statute or rule of law, then such
provision shall be deemed inoperative to the extent that it may conflict
therewith and shall be deemed modified to conform to such statute or rule of
law. Any provision hereof which may prove invalid or unenforceable under any law
shall not affect the validity or enforceability of any other provision hereof

                  (f) This Agreement and the Subscription Agreement (including
all schedules and exhibits thereto) constitute the entire agreement among the
parties hereto with respect to the subject matter hereof and thereof. There are
no restrictions, promises, warranties or undertakings, other than those set
forth or referred to herein and therein. This Agreement and the Subscription
Agreement supersede all prior agreements and understandings among the parties
hereto with respect to the subject matter hereof and thereof

                  (g) The headings in this Agreement are for convenience of
reference only and shall not form part of, or affect the interpretation of, this
Agreement.

<PAGE>

                  (h) This Agreement may be executed in two or more
counterparts, each of which shall be deemed an original but all of which shall
constitute one and the same agreement and shall become effective when
counterparts have been signed by each party and delivered to the other party.
This Agreement, once executed by a party, may be delivered to the other party
hereto by facsimile transmission of a copy of this Agreement bearing the
signature of the party so delivering this Agreement.

                  (i) Each party shall do and perform, or cause to be done and
performed, all such further acts and things, and shall execute and deliver all
such other agreements, certificates, instruments and documents, as the other
party may reasonably request in order to carry out the intent and accomplish the
purposes of this Agreement and the consummation of the transactions contemplated
hereby.

                  (j) Except as otherwise provided herein, all consents and
other determinations to be made by the Investors pursuant to this Agreement
shall be made by Investors owning at least seventy-five percent (75%) of the
Registrable Securities, determined as if all of the Warrants then outstanding
have been converted into Registrable Securities.

                  (k) The Company acknowledges that a breach by it of its
obligations hereunder will cause irreparable harm to each Investor by vitiating
the intent and purpose of the transactions contemplated hereby. Accordingly, the
Company acknowledges that the remedy at law for breach of its obligations under
this Agreement will be inadequate and agrees, in the event of a breach or
threatened breach by the Company of any of the provisions under this Agreement,
that each lnvestor shall be entitled, in addition to all other available
remedies in law or in equity, and in addition to the penalties assessable
herein, to an injunction or injunctions restraining, preventing or curing any
breach of this Agreement and to enforce specifically the terms and provisions
hereof without the necessity of showing economic loss and without any bond or
other security being required.

                  (l) The language used in this Agreement will be deemed to be
the language chosen by the parties to express their mutual intent, and no rules
of strict construction will be applied against any party.

         IN WITNESS WHEREOF, the Company and the undersigned Investors have
caused this Agreement to be duly executed as of the date first above written.

CYTOMEDIX, INC.                             INVESTOR:

____________________________________        ____________________________________
By:      Kent Smith
         Chief Executive Officer

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