Document:

Thirteenth Amendment

 Exhibit 10.280 
 THIRTEENTH LEASE AMENDMENT 
 THIS THIRTEENTH LEASE AMENDMENT (this
“Thirteenth Amendment”) is made and entered into this 29th day of September 2011, by and between GREENWAY OFFICE CENTER L.L.C. (the “Landlord”) and PPD DEVELOPMENT, LP (the “Tenant”).

 RECITALS: 
 A. Tenant (as successor to PPD Development, LLC) and Landlord (as successor to Greenway Properties, Inc. f/k/a Western Center Properties, Inc.) have entered into that certain lease with respect to space
in the building located at 8551 Research Way, Middleton, Wisconsin, dated April 30, 2001 (the “Lease”), which Lease was subsequently amended on August 15, 2001, August 25, 2003, March 22,
2004, May 17, 2004, December 14, 2004, June 3, 2005, July 29, 2005, March 1, 2006, August 31, 2007, September 25, 2007, March 31, 2008, and February 10, 2011; and

 B. Tenant and Landlord desire to amend the Lease as set forth herein. 

AGREEMENT: 

FOR GOOD AND VALUABLE CONSIDERATION, the receipt and sufficiency of which the parties hereby acknowledge, Landlord and Tenant agree as follows:

 1. Article 1 of the Lease is hereby replaced in its entirety with the following: 

“ARTICLE 1 
 TERMS 
 1.1 Date of Lease. April 30, 2001. 

1.2 Landlord: Greenway Office Center L.L.C., a Delaware limited liability company, with it address at: 

8215 Greenway Boulevard, Suite 500, 
 Middleton, WI 53562 (courier address) 
 P.O. Box 7700 

Madison, WI 53707-7700 (mailing address) 
 Attn: Chief Legal Officer 
 The address for Landlord set forth in
Section 16.6 is hereby replaced with the above. 
 1.3 Tenant: PPD Development, LP, a Texas limited partnership, with
its address at: 
 929 North Front Street 
 Wilmington, NC 28401-3331 
 Attn: Corporate Lease Administration with copy to
General Counsel at same address 
 The address for Tenant set forth in Section 16.6 is hereby replaced with
the above. 
 1.4 Building: The Building is located at 8551 Research Way, Middleton, WI 53562. “Rentable Square
Footage of the Building” is deemed to be 190,549 square feet. 
 1.5 Premises: The Premises shall mean the area shown
on Exhibit A to this Lease. “Rentable Square Footage of the Premises” is deemed to be 125,761 square feet. 
 1.6
Rent: Rent shall mean the amounts payable by Tenant to Landlord as stated in Article 4. 

 1.7 Term: The Term commenced on May 1, 2001 (the “Commencement Date”)
and, unless extended in accordance with this Lease, shall end on May 31, 2023 (the “Termination Date”).” 
 2. Article 2 of
the Lease is hereby deleted in its entirety and replaced with the following: 
 “Phase IV of the Greenway Research Center
has on a non-served basis approximately 5.4 parking stalls per 1,000 square feet of usable space which should provide adequate parking for employees and guests.” 
 3. Section 4.1 is hereby replaced in its entirety with the following: 

“4.1 Rent. Tenant covenants and agrees to pay Landlord as Rent, in advance, on the first day of each month, without demand
thereof, the “Monthly Base Rent” set forth in the table below, along with its prorated share of the Common Area Expenses (as defined in Section 4.4). The term “Monthly Base Rent” shall also mean and refer to “Monthly
Rent” as that term is used in the Lease. 
  

													
	 Period or Months of Term
	  	Annual Rate Per Square Foot	 	  	Monthly Base Rent	 	 	 	 
	 09/01/2011 to 02/28/2012
	  	$	15.40	  	  	$	161,393.28	  	 
	 03/01/2012 to 02/29/2013
	  	$	15.86	  	  	$	166,235.08	  	 
	 03/01/2013 to 02/28/2014
	  	$	16.34	  	  	$	171,222.13	  	 
	 03/01/2014 to 02/28/2015
	  	$	16.83	  	  	$	176,358.80	  	 
	 03/01/2015 to 02/28/2016
	  	$	17.33	  	  	$	181,649.56	  	 
	 03/01/2016 to 02/29/2017
	  	$	17.85	  	  	$	187,099.05	  	 
	 03/01/2017 to 02/28/2018
	  	$	18.39	  	  	$	192,712.02	  	 
	 03/01/2018 to 02/28/2019
	  	$	18.94	  	  	$	198,493.38	  	 
	 03/01/2019 to 02/28/2020
	  	$	19.51	  	  	$	204,448.18	  	 
	 03/01/2020 to 02/29/2021
	  	$	20.09	  	  	$	210,581.63	  	 
	 03/01/2021 to 02/28/2022
	  	$	20.70	  	  	$	216,899.08	  	 
	 03/01/2022 to 02/28/2023
	  	$	21.32	  	  	$	223,406.05	  	 
	 03/01/2023 to 05/31/2023
	  	$	21.96	  	  	$	230,108.23	  	 
		  				  				 	 	”	  

 4. Section 4.5 is hereby replaced in its entirety with the following: 

“4.5. Proration: Tenant’s “prorated share” shall mean the Rentable Square Footage of the Premises divided by
the Rentable Square Footage of the Building, which equals 66.00 percent.” 
 5. Section 4.6 is hereby added to the Lease to read as
follows: 
 “4.6 Rent Credit. Unless Tenant is then in default under Article 11, beginning on April 1, 2022,
Tenant shall have a right to receive a credit against its future Base Rent in the amount of $3,000,000. Tenant may start offsetting the rent credit against the Base Rent due on April 1, 2022, and each subsequent month thereafter.
Notwithstanding the above, if Tenant does not extend this Lease through at least May 31, 2026, Tenant will instead receive a credit against its future Base Rent in the amount of $2,250,000. 

6. Section 6.2 (d) is hereby added to the Lease to read as follows: 
 “(d) Tenant shall be responsible for payment of electric service charges under the Madison Gas and Electric Service Agreement for Purchase of Backup Generation Service, dated December 16, 2004
(the “MGE Agreement”). On or before the termination date of the MGE Agreement, Tenant shall enter into its own service agreement for purchase of backup generation service from Madison Gas and Electric Company.” 

7. Section 16.23 of the Lease is hereby replaced in its entirety with the following: 

“16.23 Right of First Refusal. Throughout the Term of the Lease, Tenant shall have right of first refusal with respect to any
space located in the Building (the “ROFR Space”), subject to other tenant(s) then existing rights of first refusal for the same space. In the event a third party wishes to lease the ROFR Space, Landlord shall notify Tenant of the
terms upon which the third party is willing to lease the ROFR Space and 

  
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Tenant shall have five (5) business days from the date of such notice to inform Landlord that Tenant wishes to lease the ROFR Space. If Landlord does not receive a response from Tenant
within such five (5) day period, Landlord may rent the ROFR Space to the third party. If Tenant wishes to exercise its right of first refusal for the ROFR Space, Tenant must lease the ROFR Space upon the same terms and conditions as the
bona-fide, negotiated proposal from the third party.” 
 8. Section 16.24 is hereby added to the Lease to read as follows: 

“16.24. Renewal Option. Landlord hereby grants Tenant two (2) options (each, a “Renewal Option”) to
extend the then current Term of this Lease with respect to the entire Premises for five (5) years each (each, a “Renewal Term”) by delivering written notice of exercise of the Renewal Option to Landlord not later than eighteen
months (18) months in advance of the expiration of the then current Term. Landlord shall then provide Tenant with Landlord’s estimate of the fair market base rent for the Premises (“Fair Market Rent”). The Base Rent for
the Renewal Term shall equal ninety-five percent (95%) of the estimated Fair Market Rent. Landlord shall determine the “fair market” rent and refurbishment allowance by analyzing comparable space in the Middleton/West Madison,
Wisconsin area. In the event Tenant disputes Landlord’s determination of Fair Market Rent or the refurbishment allowance for the Renewal Term, Landlord and Tenant shall within thirty (30) days after the date on which the Landlord provides
Tenant with its estimate of Fair Market Rent shall each simultaneously submit to the other, in writing, its good faith estimate of the Fair Market Rental Rate (“Good Faith Estimates”). If the higher of the Good Faith Estimates is
not more than one hundred and five percent (105%) of the lower of the Good Faith Estimates, the Fair Market Rent in question shall be deemed to be the average of the submitted rates. If otherwise, then the rate shall be set by arbitration to be
held in Madison, Wisconsin in accordance with the Real Estate Valuation Arbitration Rules of the American Arbitration Association, except that the arbitration shall be conducted by a single arbitrator as follows. Within ten (10) days after the
simultaneous submittal by Landlord and Tenant of their respective Good Faith Estimates, each shall designate a recognized and independent commercial real estate attorney or MAI appraiser who has at least ten (10) years recent experience in the
leasing or valuing, as applicable, of rental properties comparable to and in the vicinity of the Building, which arbitrator shall not be an affiliate of Tenant or Landlord. The two individuals so designated shall, within ten (10) business days
after the last of them is designated, appoint a third independent arbitrator possessing the aforesaid qualifications to be the single arbitrator (provided that such third arbitrator shall not have been engaged by Landlord, Tenant or the local
affiliates or agents of either of them during the preceding three (3) years). The third arbitrator so selected shall alone pick one of the two Good Faith Estimates, being the Good Faith Estimate that is closer to the Fair Market Rent as
determined by the arbitrator using the definition set forth herein. The parties agree to be bound by the decision of the arbitrator, which shall be final and non-appealable, and shall share equally the costs of arbitration, and judgment upon the
award rendered by the arbitrator may be entered in any court having jurisdiction thereof. The phrase “Fair Market Rent” shall mean the fair market value annual rental rate that a comparable tenant would pay and a comparable landlord would
accept in an arm’s length transaction, for delivery on or about the applicable delivery or effective date of the applicable Renewal Term, for comparable non-renewal, non-expansion space, for a comparable use in the Building and in comparable
buildings within a one (1) mile radius of the Building (“Comparable Transactions”). In any determination of Comparable Transactions, appropriate consideration shall be given to the annual rental rates per rentable square foot;
the standard of measurement by which the rentable square footage is measured; the ratio of rentable square feet to usable square feet; the type of escalation clause (e.g., whether increases in additional rent are determined on a net or gross basis,
and if gross, whether such increases are determined according to a base year or a base dollar amount expense stop); provisions reflecting free or reduced rent, parking charges, length of the lease term, size, configuration and location of premises
being leased, building standard work letter or tenant improvement allowances, if any; and other generally applicable conditions of tenancy for such Comparable Transactions. The intent is that Tenant will obtain the same rent and other economic
benefits that a landlord would otherwise give in Comparable Transactions and that Landlord will make, and receive the same economic payments and concessions that a landlord would otherwise make, and receive in Comparable Transactions.”

 9. Prior Amendments. 
  

	 	9.1	Except as noted in this Section 9, this Thirteenth Amendment hereby supersedes and replaces all of the terms and conditions of the first through twelfth amendments
to the Lease, which were dated on or about August 15, 2001, August 25, 2003, March 22, 2004 (“Third Amendment”), May 17, 2004 (“Fourth Amendment”), December 14, 2004 (“Fifth
Amendment”), June 3, 2005 (“Sixth Amendment”), July 29, 2005, March 1, 2006 (“Eighth Amendment”), August 31, 2007, September 25, 2007, March 31, 2008, and February 10, 2011
(the “Prior Amendments”). Except as noted in this Section 9, the terms and conditions of the Lease shall be construed as if the Prior Amendments were never in effect. 

  
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	 	9.2	The following provisions shall continue in full force and effect and are not superseded by the terms and conditions of this Thirteenth Lease Amendment:

  

	 	i.	Sections 15, 16 and 17 of the Eighth Amendment. 

  

	 	ii.	Section 9 of the Sixth Amendment. 

  

	 	iii.	Section 3 of the Fifth Amendment. 

  

	 	iv.	Section 10 of the Fourth Amendment. 

  

	 	v.	Section 11 of the Third Amendment. 

 10.
This Amendment may be executed in any number of counterparts and by the different parties hereto in separate counterparts, each of which when so executed shall be deemed to be an original and all of which taken together shall constitute one and the
same agreement. Delivery of an executed counterpart of a signature page to this Amendment by facsimile transmission or electronic mail shall be effective as delivery of a manually executed counterpart of this Amendment. Any party so executing this
Amendment by facsimile transmission or electronic mail shall promptly deliver a manually executed counterpart, provided that any failure to do so shall not affect the validity of the counterpart delivered by facsimile transmission or electronic
mail. 
 11. All capitalized terms not defined herein shall have the meaning ascribed to them in the Lease. 

12. In the event of conflict between the provisions of this Amendment and the terms of the Lease, the provisions of this Amendment will control.

 13. The parties hereby ratify the terms and conditions of the Lease as amended by this Amendment. 

IN WITNESS WHEREOF, Landlord and Tenant have entered into this Amendment as of the date set forth in the preamble. 

 

											
	TENANT:	 		 	LANDLORD:
			
	PPD DEVELOPMENT, LP	 		 	GREENWAY OFFICE CENTER L.L.C.
					
	By:	 	PPD GP, LLC, Its General Partner	 		 	By:	 	T. Wall Properties L.L.C., Its Manager
						
	By:	 	 /s/ William J. Sharbaugh
	 		 		 	By:	 	 /s/ Randall J. Guenther

	  
 Name:
	 	  
 William J.
Sharbaugh
	 		 		 		 	Randall J. Guenther,
	 	 		 		 		 	President & Chief Financial Officer
					
	Title:	 	 Chief Operating Officer
	 		 	Date:	 	 October 10, 2011

					
	Date:	 	 September 29, 2011
	 		 		 	

  
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 EXHIBIT A 
 OUTLINE AND LOCATION OF PREMISES 
 

 

  
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 GUARANTY 
 THIS GUARANTY (this “Guaranty”) is made and entered into by and between PHARMACEUTICAL PRODUCT DEVELOPMENT, INC., a North Carolina corporation, (the
“Landlord”) and GREENWAY OFFICE CENTER L.L.C., a Delaware limited liability company (the “Guarantor”). 
 RECITALS: 
 A. Guarantor is affiliated with PPD Development, LP, a
Texas limited partnership, (the “Tenant”). 
 B. Landlord and Tenant entered into that certain lease, dated
April 30, 2001, as amended, for the premises located at 8551 Research Way, Middleton, WI 53562 (the “Lease”). 
 C. Guarantor derives a financial benefit from the execution of the Lease by Landlord and Tenant. 
 D. Guarantor desires to guaranty all of Tenant’s obligations under the Lease. 

AGREEMENT: 
 IN
CONSIDERATION of the foregoing Recitals, and in consideration of the Landlord entering into the Lease, Guarantor does hereby covenant and agree to the following: 
 1. GUARANTY OF PERFORMANCE. Guarantor guarantees, unconditionally and absolutely, the full and faithful performances and observance of all the covenants, terms, and conditions of the Lease provided
to be performed and observed by Tenant, expressly including, without being limited to, the payment of rent, when due, under the Lease. This is a guaranty of payment and performance and not of collection. 

2. LEASE MODIFICATION, RENEWAL OR EXTENSION. If the Lease is modified, renewed or extended, or if the Tenant holds over beyond the term of the
Lease, the obligations hereunder of Guarantor shall extend and apply with respect to the full and faithful performance of all of the covenants, terms and conditions of the Lease and of any such modifications, renewal or extension thereof.

 3. TENANT’S SUBLET OR ASSIGNMENT. This Guaranty shall remain and continue in effect if the Tenant sublets or assigns, whether or
not Guarantor or Landlord receives notice of such sublet or assignment or has consented to it. 
 4. BINDING ON SUCCESSORS AND ASSIGNS.
This Guaranty, and all of the terms hereof, shall be binding on Guarantor and the heirs, successors, assigns, and legal representatives of Guarantor and shall inure to the benefit of the successors, assigns, and legal representatives of
Landlord. 
 5. JOINT AND SEVERAL LIABILITY. The liability of Guarantor is co-extensive with that of Tenant and also joint and several,
and action may be brought against Guarantor and carried to final judgment either with or without making Tenant a party thereto. Guarantor further agrees that in any action or proceeding brought by Landlord against Tenant, Guarantor does not have to
be joined as a party thereto. 
 6. NO DEMAND NEEDED. Landlord may proceed against Guarantor without first making demand against Tenant
and without first bringing any action or proceeding against Tenant and without joining Tenant as a party defendant. 
 7. WAIVER OF RIGHT TO
DEFAULT NOTICE. Guarantor does not require any notice of Tenant’s nonpayment, nonperformance, or nonobservance of the covenants, terms, and conditions of the Lease. Guarantor expressly waives the right to receive such notice. 

8. TENANT’S BANKRUPTCY. Neither Guarantor’s obligation to make payment in accordance with the terms of this Guaranty, nor any remedy for
the enforcement thereof, shall be impaired, modified, released, or limited in any way by any impairment, modification, release, or limitation of the liability of Tenant or Tenant’s representatives in bankruptcy, resulting from the operation of
any present or future provision of the Bankruptcy Code of the United States or from the decision of any court interpreting the same. 

  
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 9. SERVICE OF PROCESS. Guarantor irrevocably appoints Tenant as its agent for the service of process
related to this Guaranty. Notwithstanding the proceeding, Landlord agrees to send Guarantor a copy of the legal papers served on Tenant by certified mail, return receipt requested, at the address noted by Guarantor’s signature below.

 10. VENUE AND INTERPRETATION OF GUARANTY. Venue for any action or proceeding arising out of this Guaranty shall be Dane County in the
State of Wisconsin. The internal laws of the State of Wisconsin shall govern the interpretation, validity, performance and enforcement of this Guaranty. The invalidity or unenforceability of any provision of this Guaranty shall not affect or impair
any other provision. Both parties have been either represented by legal counsel or given the chance to review this Guaranty with legal counsel, and therefore, the provisions of this Guaranty shall be construed as their fair meaning, and not for or
against any party based upon any attributes to such party of the source of the language in question. 
 11. WAIVER OF JURY TRIAL.
Guarantor hereby waives the right to trial by jury in any action or proceeding that may hereafter be instituted by Landlord against Guarantor in respect of this Guaranty. 
 12. LANDLORD’S LEGAL EXPENSES. Landlord shall be entitled to all of its costs and expenses, including, without limitation, reasonable attorneys’ fees, if Landlord institutes a suit
against Tenant or Guarantor for violation of, or to enforce any covenant, term or condition of, the Lease or this Guaranty. 
 13. NO WAIVER
BY LANDLORD. Landlord’s failure or delay in exercising any rights under the Lease or this Guaranty or in sending any notices, or requests, or in requiring strict performance or observance of any term or covenant of the Lease, shall not
waive any of Landlord’s rights created by this Guaranty. 
 14. COUNTERPARTS; FACSIMILE. This Guaranty may be executed in any number
of counterparts and by different parties hereto in separate counterparts, each of which when so executed shall be deemed to be an original and all of which taken together shall constitute one and the same agreement. Delivery of an executed
counterpart of a signature page to this Guaranty by facsimile transmission or electronic mail shall be effective as delivery of a manually executed counterpart of this Guaranty. Any party so executing this Guaranty by facsimile transmission or
electronic mail shall promptly deliver a manually executed counterpart, provided that any failure to do so shall not affect the validity of the counterpart delivered by facsimile transmission or electronic mail. 

IN WITNESS WHEREOF, Landlord and Guarantor have executed this Guaranty as of the date it is executed by both of the parties. 

 

													
	GUARANTOR:	 		 		 	LANDLORD:	 	
			
	PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.	 		 	GREENWAY OFFICE CENTER L.L.C.
						
		 		 		 		 	By:	 	T. Wall Properties L.L.C., Its Manager
	X	 	  
	 		 		 		 		 	
							
	Name:	 	  
	 		 		 		 	By:	 	  

							
	Address:	 	  
	 		 		 		 	Name:	 	  

							
		 	  
	 		 		 		 	Title:	 	  

							
		 	  
	 		 		 		 	Date:	 	  

							
	Date:	 	  
	 		 		 		 		 	

  
 8Employment Agreement

 Exhibit 10.281 
 EMPLOYMENT AGREEMENT 
 THIS EMPLOYMENT AGREEMENT (the
“Agreement”), is made and entered into on this
16th day of September, 2011 (the “Effective
Date”), by and between Pharmaceutical Product Development, Inc., a North Carolina corporation (the “Company”), with a mailing address for notice purposes of 929 North Front Street, Wilmington, North Carolina 28401, Attention:
Executive Chairman of the Board, and Raymond H. Hill (“Employee”), an individual whose mailing address for notice purposes is 929 North Front Street, Wilmington, North Carolina 28401. 

RECITALS 

A. The Company is a contract research organization engaged in the business of providing drug discovery and development services to
pharmaceutical, biotechnology, medical device, government and academic organizations throughout the world (the “Business”). 
 B. The Company desires to employ Employee and Employee desires to be employed by the Company, all upon the terms and conditions set forth herein. 

NOW, THEREFORE, in consideration of the foregoing recitals, the mutual covenants of the parties hereinafter set forth and other
good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows: 
 ARTICLE 1 
 EMPLOYMENT AND DUTIES 

1.1 Employment of Employee. On the Effective Date, the Company agrees to employ Employee and Employee accepts such employment
pursuant and subject to the terms and conditions of this Agreement. 
 1.2. Duties and Powers. During the Employment
Period (as defined herein), Employee shall serve as Chief Executive Officer of the Company and will have such responsibilities, duties and authority, and will render such services for and in connection with the Company and its affiliates as are
customary in such position in a comparable company and as the Executive Chairman or the Board of Directors of the Company (the “Board”) shall from time to time reasonably direct. Employee shall devote Employee’s full business time and
attention exclusively to the Business of the Company and shall use best efforts to faithfully carry out Employee’s duties and responsibilities hereunder. During the Employment Period (as defined herein), Employee may serve on charitable and
civic boards, subject to the prior approval of the Executive Chairman, which approval shall not be unreasonably withheld, so long as such board position(s) do not limit or interfere with Employee’s duties to the Company hereunder or breach any
agreement between Employee and the Company. Employee shall comply 

 
with all personnel policies and procedures of the Company as the same now exist or may be hereafter implemented by the Company from time to time, including those policies contained in the
Company’s employee manual or handbook which sets forth policies and procedures generally for employees of the Company and its subsidiaries and affiliates (the “Handbook”) to the extent not inconsistent with this Agreement. The Company
will nominate and use its reasonable best efforts to have Employee elected and re-elected to a seat on the Company’s Board of Directors during the Employment Period. 
 ARTICLE 2 
 TERM OF EMPLOYMENT 

Unless sooner terminated as provided elsewhere in this Agreement, Employee’s employment under this Agreement shall begin on the
Effective Date and end at 11:59 p.m. Eastern Time on September 15, 2013 (“Initial Employment Period”). Thereafter, this Agreement shall automatically renew for successive one-year periods, unless either the Company or Employee
provides written notice to the other at least ninety (90) days prior to the termination of the Initial Employment Period or any renewal period stating said party’s desire to terminate this Agreement. The Initial Employment Period and any
extension or renewal thereof shall be referred to herein together as the “Employment Period”. Notwithstanding anything to the contrary contained herein, the Employment Period is subject to termination pursuant to Article 4 hereof.

 ARTICLE 3 
 COMPENSATION AND BENEFITS 
 3.1 Base Salary. The Company will pay
Employee an annual base salary at a rate of $575,000 per annum (the “Base Salary”), payable in accordance with the Company’s regular payroll policy for salaried employees. The Base Salary of Employee may be subject to increase (but
not decrease) annually during the Employment Period by the Company. Except as set forth in Section 4.2.(b) hereof, if the Employment Period is terminated “For Cause” pursuant to Article 4 hereof or is otherwise shorter than a full
contract year, then the Base Salary for any partial year will be prorated and paid through the date of termination based on the number of days elapsed in such year during which services were actually performed by Employee, and the Company shall have
no further obligation to pay the Employee’s Base Salary following the date of termination. Notwithstanding anything herein to the contrary, the Company shall not be obligated to pay Employee the Base Salary during any period in which Employee
has exhausted Employee’s paid time off and is either (a) receiving short-term or long-term disability benefits under any policy or program maintained by the Company, (b) on Family and Medical Leave Act leave, or (c) is unable to
perform Employee’s essential job duties by reason of a physical or mental incapacity or disability with or without a reasonable accommodation. 
 3.2 Benefits. 
 a. During the Employment Period, Employee shall be eligible
to participate in and/or receive benefits under the health insurance, group term life/AD&D, 

  
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short and long-term disability, retirement, paid-time off, deferred compensation and other plans maintained from time to time by the Company, subject in each instance to Employee meeting all
eligibility and qualification requirements of such plans. During the Employment Period, Employee shall be entitled to twenty-seven (27) days of paid-time-off annually, subject to the provisions of the Handbook. 

b. In addition to the benefits provided in (a) above, during the Employment Period, Employee shall be entitled to participate in
(i) the employee incentive compensation plan maintained for employees of the Company, as the same may be amended from time to time (the “Incentive Compensation Plan”), and (ii) the 1995 Equity Compensation Plan maintained by PPD,
as the same has been and may be amended from time to time, or any successor plan (the “ECP”), subject in each instance to Employee meeting all eligibility and qualification requirements of such plans. 

3.3 Equity Grants. 
 a. Initial Stock Option Grant. The Company shall grant to Employee on the first day of the Initial Employment Period non-qualified options to purchase 150,000 shares of PPD’s common stock.
Said stock options shall be granted under the terms and conditions of the ECP and subject to Employee’s execution or acceptance of all documents, terms and conditions required by PPD to effectuate the grant of stock options. In addition to all
such terms and conditions, said stock options shall be (i) subject to a three-year linear vesting schedule under which one-third of the total number of stock options granted will vest on the three anniversaries of the stock option grant and
will be priced based on the Nasdaq closing price of the Company’s common stock on the first day of the Initial Employment Period. 
 b. Restricted Stock Grant. The Company shall grant to Employee on the first day of the Initial Employment Period a restricted stock award for 30,000 shares of PPD’s common stock. Said
restricted stock award shall be granted under the terms and conditions of the ECP and the Company’s standard Restricted Stock Award Agreement to be entered into by PPD and Employee. In addition to the other terms and conditions of the ECP and
the Restricted Stock Award Agreement, said restricted stock award shall be subject to a three-year linear vesting schedule under which one-third of the total number of shares of restricted stock granted will vest on the three anniversaries of the
restricted stock grant. 
 c. Restriction on Equity Grants. Employee expressly understands that should a Change in
Control (as defined herein) of the Company occur within twelve months of the Effective Date, Employee will be required to contribute the equity grants referenced herein in Sections 3.3.a. and 3.3.b. to effect any such transaction. The Company will
use commercially reasonable efforts to structure any Change in Control and contribution of Employee’s equity grants in a manner that will defer Employee’s tax obligations resulting from such contribution. At Employee’s election,
Employee may surrender and/or sell a portion of such equity grants in order to cover any tax liability resulting from such contribution. For purposes of this Agreement, “Change in Control” means (i) a change of control of a nature
that would be required to be reported in 

  
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response to Item 6(e) of Schedule 14A of Regulation 14A promulgated under the Securities Exchange Act of 1934, as amended (“Exchange Act”), provided that such a Change in Control
shall be deemed to have occurred if any “person” (as such term is used in Sections 13(d) and 14(d)(2) of the Exchange Act) is or becomes the beneficial owner, directly or indirectly, of securities of the Company representing 50% or more of
the combined voting power of the Company’s then outstanding securities; (ii) a sale of substantially all of the assets of the Company; or (iii) a liquidation of the Company. 

3.4 Expenses. The Company will reimburse Employee, in accordance with and subject to Employee’s compliance with the
Company’s policy, for Employee’s necessary and reasonable out-of-pocket expenses incurred in the course of performance of Employee’s duties hereunder. In addition, the Company will reimburse Employee for his reasonable attorneys’
fees in connection with entering into this Agreement, up to $10,000. All reimbursement of expenses to Employee hereunder shall be conditioned upon presentation of sufficient documentation evidencing such expenses. 

3.5 Working Facilities. Employee shall work out of the Company’s worldwide headquarters located in Wilmington, North
Carolina. The Company shall furnish Employee with such office space, equipment, technical, secretarial and clerical assistance and such other facilities, services and supplies as shall be reasonably necessary and suitable to his position to enable
Employee to perform the duties required of Employee hereunder in an efficient and professional manner. 
 ARTICLE 4 

TERMINATION OF EMPLOYMENT 
 4.1 Basis for Termination. Notwithstanding any other provision in this Agreement to the contrary, the Employment Period and Employee’s employment hereunder shall terminate effective on the
date indicated upon the happening of any of the following events: 
 a. Upon the death of Employee, effective immediately on the
date of death without any notice; 
 b. Upon a determination by the Executive Chairman of the Company or the Board, acting in
good faith but made in the Executive Chairman’s or Board’s sole discretion, that Employee has a physical or mental incapacity or disability which renders Employee unable to perform Employee’s essential job duties under this Agreement
with or without reasonable accommodation for a period in excess of ninety (90) days during any twelve-month period hereunder, effective upon the date said determination is communicated in writing to Employee or such later date as specified
therein; provided, however, that during any period of Disability during which the Employee is receiving compensation under the Company’s short term disability policy, the Company will pay to Employee, minus any applicable taxes and
withholdings, an amount equal to the difference between such short term disability payments and Employee’s then current base salary. Company shall not have the right to terminate Employee by reason of disability if such termination would
terminate Employee’s receipt of or right to receive short-term or 

  
 4 

 
long-term disability benefits under any policy or program maintained by the Company; provided, further, nothing herein shall give the Company the right to terminate Employee prior to discharging
its obligations to Employee, if any, under the Family and Medical Leave Act, the Americans with Disabilities Act, or any other applicable law; or 
 c. Upon a determination by the Board, acting in good faith but made in the Board’s sole discretion, that there is ground for termination for “Cause.” “Cause” will exist where
Employee: (i) willfully or repeatedly failed to substantially perform Employee’s reasonable and lawful duties and responsibilities for the Company and/or committed a material violation of any material Company policy or procedure (including
without limitation any policy or procedure described in the Handbook); (ii) willfully, intentionally or negligently engaged in any act or omission that injures, or, in the opinion of the Board, is more likely than not to materially injure the
business or reputation of the Company, including but not limited to injury to any director, employee, client or shareholder of the Company; (iii) demonstrated repeated, willful or gross negligence and/or willful misconduct in Employee’s
execution of duties for the Company (including but not limited to insubordination); (iv) engaged in a form of discrimination or harassment prohibited by law (including, without limitation, discrimination or harassment based on race, color,
religion, sex, national origin, age, disability, and/or genetic information); (v) misappropriated or embezzled any tangible or intangible property of the Company; (vi) breached any of the material terms of this Agreement and/or any other
written agreement between Employee and the Company; and/or (vii) has been indicted on charges or convicted or pleaded guilty or no contest to a felony; in each case effective upon the date said determination is communicated in writing to
Employee or such later date as specified therein. 
 d. Upon written notice by either Employee or the Company to the other
party, effective on the date set forth in such notice or such earlier date as the Company may provide. 
 4.2 Compensation
After Termination. 
 a. If (i) the Company terminates Employee’s employment during the Employment Period pursuant
to Section 4.1.a, 4.1.b, or 4.1.c hereof, (ii) either party terminates this Agreement pursuant to Article 2 hereof or (iii) Employee voluntarily terminates this Agreement pursuant to Section 4.1.d hereof, then the Employment
Agreement and Employee’s employment with the Company shall terminate and the Company shall have no further obligations hereunder or otherwise with respect to Employee’s employment from and after the termination or expiration date, except
that the Company shall pay Employee’s Base Salary accrued through the date of termination or expiration and shall provide such benefits as are required by applicable law. Notwithstanding the foregoing, if the Company terminates Employee
pursuant to Section 4.1.a or 4.1.b, the Company will pay to Employee a pro rata share of any incentive compensation earned by Employee during the year in which such termination occurs, such incentive compensation to be determined and payable in
the same manner and at the same time as it would have been had Employee’s employment not been terminated pursuant to Section 4.1.a or 4.1.b. 

  
 5 

 b. If the Company terminates the Employee’s employment pursuant to Section 4.1.d
hereof, then the Company shall have no further obligations hereunder or otherwise with respect to Employee’s employment from and after the termination date, except that, subject to receiving a signed separation agreement and general release of
claims from Employee substantially in the form set out in attached Exhibit 1 to this Agreement, modified as necessary so as to be fully enforceable under current applicable law, Company shall pay Employee’s Base Salary through the end of
the then current Employment Period and shall provide benefits as are required by applicable law. However, any payments under this Section 4.2.b. payable after termination of employment may be delayed as may be required by Section 7.12
hereof. Provided, however, if the termination of Employee’s employment results in compensation and benefits being provided to Employee pursuant to the Severance Agreement of even date herewith, Employee shall receive no compensation under this
Section 4.2, except for Base Salary and benefits accrued through the date of termination or as are otherwise required by applicable law. 
 4.3 Continuing Rights upon Termination of Employment Period. Notwithstanding any termination or expiration of this Agreement, the Company shall continue to have all other rights available
hereunder, including without limitation all rights under the Proprietary Agreement and/or the Non-Competition Agreement (as hereinafter defined). 
 4.4 Resignation as Officer and Director. Upon termination or expiration of Employee’s employment by either party for any reason, Employee will also be deemed to have resigned Employee’s
position(s), if any, as an officer or director of the Company, as a member of any committee the Board of Directors of the Company, as an officer, director, manager or any other office or position of any subsidiary or affiliate of the Company, and
any other position(s) Employee holds at the request of, or for the benefit of, the Company or its subsidiaries or affiliates. 

ARTICLE 5 

PROPRIETARY INFORMATION 
 Prior to or coincident with the commencement date of this Agreement, Employee shall execute and deliver to the Company its standard Proprietary Information and Inventions Agreement (the “Proprietary
Agreement”), a copy of which is attached hereto as Annex A. 

  
 6 

 ARTICLE 6 
 NON-COMPETITION AND NON-SOLICITATION 
 Prior to or coincident with the
commencement date of this Agreement, Employee shall execute and deliver to the Company its standard Non-Competition and Non-Solicitation Agreement (the “Non-Competition Agreement”), a copy of which is attached hereto as Annex B.

 ARTICLE 7 
 MISCELLANEOUS 
 7.1 Withholding Taxes. All amounts payable under
this Agreement, whether such payment is to be made in cash or other property, shall be subject to applicable withholding requirements for Federal, state and local income taxes, employment and payroll taxes, and other legally required withholding
taxes and contributions to the extent appropriate in the determination of the Company, and Employee shall report all such amounts as ordinary income on Employee’s personal income returns and for all other purposes. 

7.2 Assignment. No party hereto may assign or delegate any of its rights or obligations hereunder without the prior written
consent of the other party hereto; provided, however, that the Company shall have the right to assign all or any part of its rights and obligations under this Agreement (i) to any member, subsidiary or affiliate of the Company or any surviving
entity following any merger or consolidation of any of those entities with any entity other than the Company, or (ii) in connection with the sale of the Business by the Company. 

7.3 Binding Effect. All covenants and agreements contained in this Agreement by or on behalf of any of the parties hereto shall be
binding upon and inure to the benefit of the respective legal representatives, heirs, successors and permitted assigns of the parties hereto. 
 7.4 Entire Agreement. This Agreement, together with the Proprietary Agreement, Severance Agreement and the Non-Competition Agreement of even date herewith, sets forth the entire understanding of
the parties and supersedes and preempts all prior oral or written understandings and agreements with respect to the subject matter hereof. 
 7.5 Severability. Whenever possible, each provision of this Agreement shall be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement
is held to be prohibited by or invalid under applicable law, such provision shall be ineffective only to the extent of such prohibition or invalidity, without invalidating the remainder of this Agreement. 

7.6 Amendment; Modification. No amendment or modification of this Agreement and no waiver by any party of the breach of any
covenant contained herein shall be binding unless executed in writing by the party against whom enforcement of such amendment, modification or waiver is sought. No waiver shall be deemed a continuing waiver or a waiver in respect of any subsequent
breach or default, either of a similar or different nature, unless expressly so stated in writing. 

  
 7 

 7.7 Governing Law. This Agreement shall be governed by and construed and enforced in
accordance with the laws of the State of North Carolina, without giving effect to provisions thereof regarding conflict of laws. 
 7.8 Arbitration. Except for disputes, controversies or claims arising out of or related to the Proprietary Agreement and/or the Non-Competition Agreement attached as Annex A and B,
respectively, any dispute, controversy or claim arising out of or relating to this Agreement, including but not limited to its existence, validity, interpretation, performance or non-performance, or breach, shall be decided by a single neutral
arbitrator agreed upon by the parties hereto in Wilmington, North Carolina in binding arbitration pursuant to the commercial arbitration rules of the American Arbitration Association then in effect. The parties to any such arbitration shall be
limited to the parties to this Agreement or any successor thereof. The written decision of the arbitrator shall be final and binding and may be entered and enforced in any court of competent jurisdiction. Each party waives any right to a jury trial
in any such forum. Each party to the arbitration shall pay its fees and expenses, unless otherwise determined by the arbitrator. 
 7.9 Notices. All notices, demands or other communications to be given or delivered hereunder or by reason of the provisions of this Agreement shall be in writing and shall be deemed to have been
properly served if (a) delivered personally, (b) delivered by a recognized overnight courier service, (c) sent by certified mail, return receipt requested and first class postage prepaid, or (d) sent by facsimile transmission
followed by a confirmation copy delivered by a recognized overnight courier service the next day. Such notices, demands and other communications shall be sent to the address first set forth above, or to such other address or to the attention of such
other person as the recipient party has specified by prior written notice to the sending party. Date of service of such notice shall be (i) the date such notice is personally delivered or sent by facsimile transmission (with issuance by the
transmitting machine of a confirmation of successful transmission), (ii) the date of receipt if sent by certified mail, or (iii) the date of receipt if sent by overnight courier. 

7.10 Counterparts. This Agreement may be executed in multiple counterparts, each of which shall be deemed an original and all of
which taken together shall constitute one and the same agreement. 
 7.11 Descriptive Heading; Interpretation. The
descriptive headings in this Agreement are inserted for convenience of reference only and are not intended to be part of or to affect the meaning or interpretation of this Agreement. 

7.12 409A. 
 (a) It is intended that this Agreement and the payments hereunder will not be considered to constitute in whole or in part a nonqualified deferred compensation plan within the meaning of Code section 409A
and the Treasury Regulations and 

  
 8 

 
guidance promulgated thereunder (collectively, “Section 409A”) and so will be exempt from the requirements of Section 409A, and the Agreement shall be interpreted to that end to
the fullest extent possible. However, in the event that any payment or benefit (or portion thereof) provided pursuant to this Agreement is nonetheless determined to be paid from a nonqualified deferred compensation plan subject to
Section 409A, the applicable terms of this Agreement shall be interpreted in a manner that complies with Section 409A to the fullest extent possible. 
 (b) Any payment due under the Agreement of nonqualified deferred compensation within the meaning of Section 409A that is payable on termination of employment (or similar term) shall be delayed until
the Employee also has “separation from service” within the meaning of Section 409A. 
 (c) For purposes of
Section 409A, the Employee’s right to receive any installment payments pursuant to this Agreement (including payments under Section 4.2.b. hereof) shall be treated as a right to receive a series of separate and distinct payments.
Further, if an amount to be paid to the Employee under the Agreement on account of his “separation from service” while the Employee is a “specified employee” is an amount payable under a “nonqualified deferred compensation
plan” (as those terms are defined under Section 409A), any such payments that would otherwise be paid within 6 months after such separation from service shall not be paid until the first business day after the end of such six-month period,
or, if earlier, within 15 days after the appointment of the personal representative or executor of the Employee’s estate following his death, at which time such delayed payments shall be paid in a single payment without interest. 

(d) With regard to any provision herein that provides for reimbursement of costs and expenses or in-kind benefits that are not excluded
from the Employee’s taxable income, then except as permitted by Section 409A (i) the right to reimbursement or in-kind benefits shall not be subject to liquidation or exchange for another benefit; (ii) the amount of expenses
eligible for reimbursement, or in-kind benefits, provided during any taxable year shall not affect the expenses eligible for reimbursement, or in-kind benefits to be provided, in any other taxable year, provided, that the foregoing clause
(ii) shall not be violated with regard to expenses reimbursed under any arrangement covered by Section 105(b) of the Code solely because such expenses are subject to a limit related to the period the arrangement is in effect; and
(iii) such payments shall be made on or before the last day of the Employee’s taxable year following the taxable year in which the expense was incurred. 
 7.13 No General Waivers. The failure of any party at any time to require performance by any other party of any provision hereof or to resort to any remedy provided herein or at law or in equity
shall in no way affect the right of such party to require such performance or to resort to such remedy at any time thereafter, nor shall the waiver by any party of a breach of any of the provisions hereof be deemed to be a waiver of any subsequent
breach of such provisions. No such waiver shall be effective unless in writing and signed by the party against whom such waiver is sought to be enforced. 

  
 9 

 7.1.4 Indemnification. The Company shall indemnify and hold Employee harmless to the
fullest extent permitted by the laws of the Company’s state of incorporation in effect at the time against and in respect of any and all actions, suits, proceedings, claims, demands, judgments, costs, expenses (including advancement of
reasonable attorney’s fees), losses, and damages resulting from Employee’s good faith performance of Employee’s duties and obligations with the Company. Executive will be entitled to be covered, both during and, while potential
liability exists, by any insurance policies the Company may elect to maintain generally for the benefit of officers and directors of the Company against all costs, charges and expenses incurred in connection with any action, suit or proceeding to
which Employee may be made a party by reason of being an officer or director of the Company, or any subsidiary or affiliate, in the same amount and to the same extent as the Company covers its other officers and directors. These obligations
shall survive the termination of Executive’s employment with the Company. 
 IN WITNESS WHEREOF, the parties hereto
have executed this Employment Agreement as of the day and year first above written. 
  

					
	COMPANY:	 	PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.
			
		 	By:	 	 /s/ Fred N. Eshelman

		 	Name:	 	 Fred N. Eshelman

			
		 	Title:	 	 Executive Chairman

		
	EMPLOYEE:	 	 /s/ Raymond H. Hill

		 	Raymond H. Hill

 EXHIBIT 1 
 SEPARATION AGREEMENT AND 
 GENERAL RELEASE OF CLAIMS 

THIS SEPARATION AGREEMENT AND GENERAL RELEASE OF CLAIMS (the “Agreement”) is entered into as of the date last set out below by
and between Pharmaceutical Product Development, Inc., a North Carolina corporation (the 

  
 10 

 
“Company”), with a mailing address for notice purposes of 929 North Front Street, Wilmington, North Carolina 28401, Attention: Executive Chairman of the Board, and Raymond H. Hill
(“Employee”), an individual whose mailing address for notice purposes is 929 North Front Street, Wilmington, North Carolina 28401. (The Company and Employee are sometimes referred to herein as each a “Party” and together as the
“Parties.”) 
 RECITALS 
 A. Employee and the Company are parties to that certain Employment Agreement, effective as of September 16, 2011 (the “Employment Agreement”); and 

B. Employee’s employment is being terminated by the Company pursuant to Section 4.1.d of the Employment Agreement; and

 C. A condition to Employee’s receipt of certain payments post-termination is the execution of this Agreement; and

 D. Unless otherwise defined herein, capitalized terms not specifically defined in this Agreement will have the same
definition as provided in the Employment Agreement. 
 NOW, THEREFORE, in consideration of the covenants and mutual promises
contained herein, as well as the payment of certain consideration to Employee as hereinafter recited, the receipt and sufficiency of which are hereby acknowledged by Employee, it is agreed as follows: 

1. Termination. Employee’s employment with the Company is terminated effective as of [DATE] (the “Termination
Date”). Except as set out in this Agreement, as provided by the specific terms of a benefit plan or award (or similar) agreement or as required by law, upon the termination of Employee’s employment with the Company, effective as of the
Termination Date, all of Employee’s employee benefits with the Company will terminate. Employee hereby represents that he has returned to the Company all documents, records, apparatus, equipment and other physical property, or any reproduction
of such property, whether or not pertaining to Proprietary Information, furnished to Employee by the Company or produced by Employee or others in connection with Employee’s employment; provided, however, that subject to the Company’s right
to inspect and redact any Proprietary Information there from, Employee may retain possession of his personal rolodex. Employee hereby acknowledges that, other than as provided in this Agreement, he has been paid all wages for labor or services
rendered by him for the Company or on the Company’s behalf through the Termination Date. 
 2. Separation Pay. If
Employee signs and does not revoke this Agreement as provided in Section 10 below, the Company will pay Employee’s Base Salary (minus applicable federal, state and local payroll taxes, and other withholdings required by law or authorized
by Employee) through the end of the then current Employment Period (the 

  
 11 

 
“Separation Pay”) and shall provide benefits as are required by applicable law. Employee will receive the Separation Pay in accordance with the Company’s payroll procedures
beginning on the sixtieth (60th) day following the
Termination Date. However, any payments under this Section may be delayed as may be required by Section 7.12 of the Employment Agreement. 

If Employee does not sign this Agreement and return it to the Company within [twenty-one (21)] [forty-five (45)] days, or if Employee revokes it
pursuant to Section 10, below, Employee will not be entitled to receive the Separation Pay described above. 
 3.
Release of Claims. In exchange for the Company’s providing Employee with the Separation Pay described in Section 2, above, by signing this Agreement, Employee hereby releases and forever discharges the Company, as well as its parent
companies, affiliates, subsidiaries, divisions, officers, directors, stockholders, employees, agents, representatives, attorneys, lessors, lessees, licensors and licensees, and their respective successors, assigns, heirs, executors and
administrators (collectively, the “Company Parties”), from any and all claims, demands, and causes of action of every kind and nature, whether known or unknown, direct or indirect, accrued, contingent or potential, which Employee ever had
or now has, including but not limited to any claims arising out of or related to Employee’s employment with the Company and the termination thereof (except where and to the extent that such a release is expressly prohibited or made void by
law). This release includes, without limitation, Employee’s release of the Company and the Company Parties from any claims by Employee for lost wages or benefits, stock options, restricted stock, compensatory damages, punitive damages,
attorneys’ fees and costs, equitable relief or any other form of damages or relief. In addition, this release is meant to release the Company and the Company Parties from all common law claims, including claims in contract or tort, including,
without limitation, claims for breach of contract, wrongful or constructive discharge, intentional or negligent infliction of emotional distress, misrepresentation, tortious interference with contract or prospective economic advantage, invasion of
privacy, defamation, negligence or breach of any covenant of good faith and fair dealing. Employee also specifically and forever releases the Company and the Company Parties (except where and to the extent that such a release is expressly prohibited
or made void by law) from any claims based on unlawful employment discrimination or harassment , including, but not limited to, the Federal Age Discrimination in Employment Act (29 U.S.C. § 621 et. seq.). This release does
not include Employee’s right to indemnification, and related insurance coverage, under Section 7.1.4 of the Employment Agreement, his right to equity awards, or continued exercise, pursuant to the terms of any specific equity award (or
similar) agreement between Employee and the Company nor to Employee’s right to benefits under any Company plan or program in which Employee participated and is due a benefit in accordance with the terms of the plan or program as of the date
hereof. 
 Employee acknowledges that this release applies both to known and unknown claims that may exist between Employee and the Company and
the Company Parties. Employee expressly waives and relinquishes all rights and benefits that Employee may have under any state or federal statute or common law principle that would otherwise limit the effect

  
 12 

 
of this Agreement to claims known or suspected prior to the date Employee executes this Agreement, and does so understanding and acknowledging the significance and consequences of such specific
waiver. In addition, Employee hereby expressly understands and acknowledges that it is possible that unknown losses or claims exist or that present losses may have been underestimated in amount or severity, and Employee explicitly took that into
account in giving this release. 
 By signing this Agreement, Employee agrees and acknowledges that he has no cause to believe that any
violation of any local, state or federal law that has occurred with respect to his employment or separation of employment from the Company. Provided, however, that nothing in this Agreement extinguishes any claims Employee may have against the
Company for breach of this Agreement. 
 4. No Admissions. Employee understands, acknowledges and agrees that the release
set out above in Section 3 is a final compromise of any potential claims by Employee against the Company and/or the Company Parties in connection with his employment by the Company, and is not an admission by the Company or the Company Parties
that any such claims exist or that the Company or any of the Company Parties are liable for any such claims. To the greatest extent permitted by law, Employee further agrees not to hereafter, directly or indirectly, sue, assist in or be a voluntary
party to any litigation against Company or any one or more of the Company Parties for any claims relating to events occurring prior to or simultaneously with the execution of this Agreement, including but not limited to Employee’s termination
of employment with the Company. 
 Notwithstanding the foregoing, nothing in this Agreement prohibits Employee from filing a
charge with, or participating in any investigation or proceeding conducted by, the U.S. Equal Employment Opportunity Commission or a comparable state or federal fair employment practices agency; provided, however, that this Agreement fully and
finally resolves all monetary matters between Employee and the Company and the Company Parties, and by signing this Agreement, Employee is waiving any right to monetary damages, attorneys’ fees and/or costs related to or arising from any such
charge, complaint or lawsuit filed by Employee or on his behalf, individually or collectively. 
 5. Withholding Taxes.
All amounts payable under this Agreement, whether such payment is to be made in cash or other property, shall be subject to applicable withholding requirements for Federal, state and local income taxes, employment and payroll taxes, and other
legally required withholding taxes and contributions to the extent appropriate in the determination of the Company. 
 6.
Future Conduct. Employee agrees that he will not denigrate, defame, disparage or cast aspersions upon the Company, the Company Parties, their products, services, business and manner of doing business, and that he will use his reasonable best
efforts to prevent any member of his immediate family from engaging in any such activity. The Company agrees that its Board of Directors and senior executives will not denigrate, defame, disparage or cast aspersions upon Employee, his services,

  
 13 

 
business and manner of doing business. Employee further agrees that in exchange for the Separation Pay, during any period of time when Employee is receiving such Separation Pay, Employee will
make himself reasonably available to render, and to render at the request of the Company, services as are deemed reasonably necessary by the Company to effect an orderly transition of Employee’s duties to other employees of the Company. In
addition, Employee further agrees to provide reasonable assistance upon the request of the Company related to any litigation in which he may be of assistance or in which his testimony is required. Executive shall be entitled to reasonable
compensation and reimbursement of necessary expenses in rendering such assistance. Employee also hereby acknowledges and agrees that his post-employment duties and obligations under the Proprietary Information and Inventions Agreement and the
Non-Competition and Non-Solicitation Agreement signed in connection with his employment with the Company will remain in full force and effect in accordance with their terms, and that any breach of such agreements will also constitute a breach of
this present Agreement in accordance with Section 7 below. 
 7. Relief and Enforcement. Employee understands and
agrees that if he violate the terms of Section 6 of this Agreement, he will cause injury to the Company (and/or one or more of the Company Parties) that will be difficult to quantify or repair, so that the Company (and/or the Company Parties)
will have no adequate remedy at law. Accordingly, Employee agrees that if he violates Sections 6 of this Agreement, the Company (or the Company Parties) will be entitled as a matter of right to obtain an injunction from a court of law, restraining
Employee from any further violation of this Agreement. The right to an injunction is in addition to, and not in lieu of, any other remedies that the Company (or the Company Parties) has at law or in equity. 

8. No Modifications; Governing Law; Entire Agreement. This Agreement cannot be changed or terminated verbally, and no modification
or waiver of any of the provisions of this Agreement will be effective unless it is in writing and signed by both Parties. The Parties agree that this Agreement is to be governed by and construed in accordance with the laws of the State of North
Carolina, and that any suit, action or charge arising out of or relating to this Agreement will be adjudicated in the state or federal courts in Wake County, North Carolina. This Agreement sets forth the entire and fully integrated understanding
between the Parties with respect to the subject matter hereof, and there are no representations, warranties, covenants or understandings regarding the subject matter hereof, oral or otherwise, that are not expressly set out herein. 

9. Voluntary Execution. By signing below, Employee and the Company each acknowledge that he has read this Agreement, that he
understands its contents and that he has relied upon or had the opportunity to seek the legal advice of his attorney, who is the attorney of his own choosing. 
 10. Right to Revoke. ONCE SIGNED BY EMPLOYEE, THIS AGREEMENT IS REVOCABLE IN WRITING FOR A PERIOD OF SEVEN (7) DAYS (THE “REVOCATION PERIOD”). IN ORDER TO REVOKE HIS ACCEPTANCE OF
THIS AGREEMENT, EMPLOYEE MUST DELIVER WRITTEN NOTICE TO [NAME], AND SUCH WRITTEN NOTICE MUST ACTUALLY BE RECEIVED WITHIN THE SEVEN (7) DAY REVOCATION PERIOD. 

  
 14 

 11. Miscellaneous. 

(a) Should any portion, term or provision of this Agreement be declared or determined by any court to be illegal, invalid or
unenforceable, the validity or the remaining portions, terms and provisions shall not be affected thereby, and the illegal, invalid or unenforceable portion, term or provision shall be deemed not to be part of this Agreement. 

(b) The Parties agree that the failure of a Party at any time to require performance of any provision of this Agreement shall not affect,
diminish, obviate or void in any way the Party’s full right or ability to require performance of the same or any other provision of this Agreement at any time thereafter. 
 (c) This Agreement shall inure to the benefit of and shall be binding upon Employee, his heirs, administrators, representatives, executors, successors and assigns and upon the successors and assigns of
the Company. 
 (d) The headings of the paragraphs of this Agreement are for convenience only and are not binding on any
interpretation of this Agreement. This Agreement may be executed in counterparts. 
 EMPLOYEE HEREBY ACKNOWLEDGES THAT HE HAS BEEN GIVEN A
PERIOD OF AT LEAST TWENTY-ONE (21) DAYS TO CONSIDER WHETHER TO EXECUTE THIS AGREEMENT. EMPLOYEE IS HEREBY ADVISED BY THE COMPANY IN WRITING TO CONSULT WITH AN ATTORNEY BEFORE SIGNING THIS AGREEMENT. 

  
 15 

 IN WITNESS WHEREOF, each of the Parties hereto has executed this Separation and Agreement
and General Release of Claims as of the date first above written. 
  

					
	PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.
		
	By:	 	  

		
	Name:	 	  

		
	Title:	 	  

		
	Date:	 	  

		
	EMPLOYEE	 	
		
	  
	 	(SEAL)
	Raymond H. Hill	 	
			
	Date:	 	  
	 	

  
 16 

 ANNEX A 

PROPRIETARY INFORMATION 
 AND INVENTIONS AGREEMENT 
 In consideration and as a condition of my
employment by Pharmaceutical Product Development, Inc., a North Carolina corporation, or any affiliate, subsidiary, successor or assigns, as the case may be (collectively referred to herein as the “Company”), I hereby agree as follows:

 1. “Proprietary Information” is information that was or is developed by, became or becomes known by, or was or is
assigned or otherwise conveyed to the Company, and which has commercial value in the Company’s business. Proprietary Information includes, without limitation, trade secrets, financial information, product plans, customer lists, marketing plans
and strategies, systems, manuals, forecasts and other business information, improvements, inventions, business strategies, business methods and practices, formulas, product ideas, biological material and techniques for their handling and use,
chemical and/or information analysis and related products and data, computer programs and software, software designs and documentation, source codes, algorithms, techniques, schematics, know-how and data, and any other confidential or proprietary
information of the Company or its customers or clients which I have been, or may be exposed to, or have learned or may learn of from time to time in connection with or as a result of my capacity as an employee of or consultant to the Company,
including during the term of this Agreement. Proprietary Information shall not include information that is, through no improper action or inaction by me, generally available to the public. I understand that my employment creates a relationship of
confidence and trust between me and the Company with respect to Proprietary Information of the Company or its customers which may be learned by me during the period of my employment. 

2. In consideration of my employment by the Company and the compensation received by me from the Company from time to time, I hereby
agree as follows: 
 (a) All Proprietary Information and all patents, copyrights, trade secret rights and other rights
(including throughout, without limitation, any extensions, renewals, continuations or divisions of any of the foregoing) in connection therewith shall be the sole property of the Company. I hereby assign to the Company any rights I may have or
acquire in such Proprietary Information. At all times, both during my employment by the Company and after its termination, I will keep in confidence and trust and will not use or disclose any Proprietary Information or anything relating to it
without the written consent of the Company, except as may be necessary in the ordinary course of performing my duties to the Company or as otherwise required by law or in any judicial or administrative process. 

 (b) In the event of the termination of my employment by me or by the Company for any reason,
I shall return all documents, records, apparatus, equipment and 

  
 2 

 
other physical property, or any reproduction of such property, whether or not pertaining to Proprietary Information, furnished to me by the Company or produced by myself or others in connection
with my employment, to the Company immediately as and when requested by the Company; provided, however, that subject to the Company’s right to inspect and redact any Proprietary Information there from, Employee may retain possession of his
personal rolodex. 
 (c) I will promptly disclose to the Company, or any persons designated by it, all “Inventions”,
which includes all improvements, inventions, formulas, ideas, works of authorship, processes, computer programs and software, software designs and documentation, algorithms, techniques, schematics, know-how data, whether or not patentable, made or
conceived or reduced to practice or developed by me, either alone or jointly with others, during the term of my employment and for six (6) months thereafter. To the extent the Company does not have rights therein hereunder, such disclosure
shall be received by the Company in confidence and does not extend the assignment made in Section (d) below. 
 (d) I agree
that all Inventions which I make, conceive, reduce to practice or develop (in whole or in part, either alone or jointly with others) during my employment shall be the sole property of the Company to the maximum extent permitted by law, and, to the
extent permitted by law, shall be “works made for hire”. The Company shall be the sole owner of all patents, copyrights, trade secret rights, and other intellectual property or other rights in connection therewith. I hereby assign to the
Company any rights I may have or acquire in such Inventions. I agree to perform, during and after my employment, all acts deemed necessary or desirable by the Company to permit and assist it, at the Company’s expense, in obtaining and enforcing
patents, copyrights, trade secret rights or other rights on such Inventions and/or any other Inventions I have or may at any time assign to the Company in any and all countries. Such acts may include, but are not limited to, execution of documents
and assistance or cooperation in legal proceedings. With respect to any and all matters arising out of or relating to my employment or consultancy with the Company, I hereby irrevocably designate and appoint the Company and its duly authorized
officers and agents, as my agents and attorneys-in-fact to act for and in my behalf and instead of me, to execute and file any applications or related filings and do all other lawfully permitted acts to further the prosecution and issuance of
patents, copyrights, trade secret rights or other rights thereon with the same legal force and effect as if executed by me. 

(e) I attach hereto a complete list of all Inventions or improvements to which I claim ownership and/or that I desire to remove from the
operation of this Agreement, and I covenant that such list is complete. If no such list is attached to this Agreement I represent that I have no such Inventions and improvements at the time of signing this Agreement. I understand that any such list
shall not contain information that breaches an obligation of confidentiality with a former employer. 
 (f) I represent that my
performance of all the terms of this Agreement will not breach any agreement or obligation to keep in confidence proprietary information acquired by me in confidence or in trust prior to my employment by the Company. I have not entered into, and I
agree I will not enter into, any agreement either written or oral in conflict herewith or in conflict with my employment with the Company. 

  
 3 

 3. The Company agrees that it will not request as part of my employment that I divulge or
make use of proprietary information of any of my former employers that has commercial value to the former employer who developed such information. 
 4. I acknowledge that in the event of my breach or threatened breach of the terms of this Agreement, the Company shall not have an adequate remedy at law and shall, in addition to any other available
rights and remedies, have the right to obtain injunctive relief, including without limitation specific performance. 
 5. This
Agreement shall be effective as of the first day of my employment by the Company, and shall be binding upon me, my heirs, executors, assigns, and administrators, and shall inure to the benefit of the Company and any current and future affiliates,
subsidiaries, successors and assigns. This Agreement supersedes any agreement which may have been previously made or executed by me relating to this matter. This Agreement shall be governed by the laws of the State of North Carolina (exclusive of
conflicts of law provisions), which shall be the venue for resolution of any dispute related to this Agreement. This Agreement or any part thereof shall not be modified, amended, or waived except by the written consent of the Company. 

Dated: September 16, 2011 
  

			
	 /s/ Raymond H. Hill
	 	
	Raymond H. Hill	 	

 Accepted and Agreed to: 
  Company 
  

					
	By:	 	 /s/ Fred N. Eshelman
	 	
	Name:	 	 Fred N. Eshelman
	 	
	Title:	 	 Executive Chairman
	 	

  
 4 

 ANNEX B 

NON-COMPETITION AND NON-SOLICITATION AGREEMENT 
 THIS AGREEMENT is made this      day of September, 2011, by and between Pharmaceutical Product Development, Inc., a North Carolina corporation, having its principal place of business
at 929 North Front Street, Wilmington, NC 28401, and Raymond H. Hill, an individual whose address for notice purposes is 929 North Front Street, Wilmington, NC 28401 (herein referred to as “Employee”). 

RECITALS 

A. Pharmaceutical Product Development, Inc., through itself, its subsidiaries, affiliates, successors and assigns (herein, collectively
referred to as “PPD”) is a contract research organization engaged in the business of providing a wide-range of drug discovery and development services to pharmaceutical, biotechnology, medical device, government and academic organizations
throughout the world (herein the “Business”). 
 B. Employee will perform a highly responsible role in PPD’s
organization, have specialized knowledge of PPD’s trade secrets and proprietary information, and have contact with or knowledge of PPD’s clients and customers. 
 C. PPD and Employee agree that because of the information and relationships to which Employee will be exposed during the course of Employee’s employment with PPD, it would be harmful to PPD for
Employee to compete with PPD or solicit its clients, customers or employees in the manner prohibited by this Agreement and that PPD has a legitimate business interest in protecting itself from such competition and solicitation. 

NOW, THEREFORE, in consideration of the foregoing and the mutual promises herein contained and other valuable consideration detailed
below, the parties agree as follows: 
 1. Restrictive Covenants. In order to protect, among other things, PPD’s
interests and investments in its trade secrets and proprietary information, its relationship with its customers, clients, employees and contractors, and its goodwill, Employee agrees to the following covenants and restrictions: 

1.1 Non-Competition Agreement. During the term of Employee’s employment with PPD and, for a period of twelve
(12) months following termination of that employment, Employee will not, directly or indirectly, participate in or engage in any business or activity which is in competition with the Business of PPD in the Territory (as defined below), whether
as an individual on his or her account or as an employee, consultant, contractor, officer, director, shareholder, partner, member, joint venturer, representative, agent or equity owner of any business entity. For the purposes of this Agreement and
the Employment Agreement of even date herewith between Employee and the Company, the “Business of PPD” shall be defined as that of a contract 

 
research organization providing drug discovery or drug development services for third parties on a fee-for-service basis. Nothing in this Agreement is intended to prohibit Employee from passively
owning two percent (2%) or less of the outstanding equity interests of any privately- or publicly-held entity. 
 1.2
Non-Solicitation of Customers. During Employee’s employment with PPD and for a period of twelve (12) months following termination of that employment, Employee will not, directly or indirectly, (a) for any business that is in
competition with the Business of PPD, solicit the business of any person, firm, corporation, partnership, limited liability company, trust or other business entity which Employee solicited, negotiated, contracted, serviced or had contact with on the
Company’s behalf during the one (1) year period prior to the termination of Employee’s employment with PPD, (b) in any other manner persuade or attempt to persuade any such person, firm, corporation, partnership, limited
liability company, trust or other business entity to discontinue or alter its business relationship with PPD, or (c) otherwise solicit for a competitive purpose or interfere with PPD’s relationship with any such person, firm, corporation,
partnership, limited liability company, trust or other business entity. 
 1.3 Non-Solicitation of Employees. During the
Employee’s employment with PPD, and for a period of twelve (12) months following termination of that employment, Employee shall not, directly or indirectly, in any manner, (a) solicit, hire, or offer to hire any employee or contractor
of PPD (other than a clerical or administrative employee) while that person is employed or engaged by PPD and for three (3) months after the termination of that person’s employment or engagement with PPD, or (b) otherwise encourage or
induce any such employee or contractor to discontinue his or her relationship with PPD. 
 2. Consideration. PPD and
Employee acknowledge that Employee has received good and valuable consideration for Employee’s commitment to be bound by the restrictions set forth in this Agreement, which consideration includes, but is not limited to Employee’s initial
employment with PPD and all of the compensation and other benefits therewith. 
 3. Territory. The restrictions contained
in this Agreement apply to all areas of the world in which PPD conducts or engages in the Business (herein the “Territory”). Employee acknowledges that, because PPD is engaged in the Business world-wide, the Territory must be so broadly
defined. 
 4. Remedies. Employee acknowledges and agrees that the covenants set forth in this Agreement are reasonable
and necessary for the protection of PPD’s legitimate business interests, that irreparable injury will result to PPD if Employee breaches any of the terms of this Agreement and that, in the event Employee breaches or threatens to breach any
provision of this Agreement, PPD will have no adequate remedy at law. Employee accordingly agrees that in the event Employee breaches or threatens to breach any of the covenants set forth herein, PPD shall be entitled to immediate, temporary and
permanent injunctive or other equitable relief without bond and without the necessity of showing actual money damages, subject to a hearing as soon as possible. 

  
 2 

 
Employee further agrees that PPD shall also be entitled to pursue, separately or concurrently, any other remedies available for such breach by Employee, including the recovery of any damages it
is able to prove. In the event Employee breaches any of the restrictions set forth herein, the time period during when the restrictions apply shall be extended for the period of the breach. 

5. Limitations on Enforcement. Employee agrees that, if a court of competent jurisdiction determines, contrary to the Agreement of
the parties, that any portion of this Agreement is unreasonable, invalid, overbroad or unenforceable, the remainder of the Agreement shall be given full effect without regard to the invalid provisions and PPD may enforce the covenant as to any
lesser area, activity or time period which is deemed by the court to be reasonable and enforceable under applicable law. In this regard, the covenants shall be divisible as to activity, time and geographic area with each month deemed to be a
separate period of time and each state and country, or part thereof, deemed to be a separate geographic area. Employee further agrees that PPD may, at its option, seek to enforce the covenant as to any lesser area, activity or time period which PPD
deems appropriate. 
 6. Effect of Termination. Employee agrees that the terms of this Agreement shall be enforceable
against the Employee regardless of the basis of Employee’s termination, whether voluntary or involuntary and with or without cause. Employee further agrees that the existence of a claim by Employee against PPD, whether predicated on
Employee’s termination, this Agreement or otherwise, shall not constitute a defense to enforcement of the restrictions contained herein. Notwithstanding the foregoing, in the event PPD terminates Employee’s employment due to a reduction in
force or layoff in connection with the discontinuation or cessation of a business line, unit, function or department, PPD shall not enforce Section 1.1 of the Agreement. 
 7. Notification. Employee authorizes PPD to notify others, in a non-disparaging and reasonable manner, including but not limited to, PPD’s customers and any future employer of Employee
concerning the terms of this Agreement and Employee’s responsibility hereunder. 
 8. Jurisdiction and Venue. The
parties agree that the federal or state courts sitting in Wilmington, North Carolina, shall be the exclusive jurisdiction to enforce the covenants set forth in this Agreement and to resolve any disputes or controversies under this Agreement.
Employee consents to personal jurisdiction and venue in either of said courts, and waives any claims or defenses based on improper venue or jurisdiction. 
 9. Attorneys’ Fees and Costs. Employee agrees that, in the event Employee breaches or threatens to breach any of the provisions of this Agreement, PPD shall be entitled to recover from
Employee all expenses incurred by it in enforcing the terms of this Agreement, including, but not limited to, its reasonable attorneys’ fees and costs. 
 10. Governing Law. This Agreement shall be construed and enforced in accordance with the laws of the State of North Carolina. 

  
 3 

 11. Severability. If any of the provisions of this Agreement is held to be invalid or
unenforceable by a court of competent jurisdiction, the remaining provisions shall continue to be valid and enforceable. 
 12.
Modification. This Agreement cannot be altered, amended, or modified in any respect, except by a writing duly executed by the parties. 
 13. Waiver. PPD’s waiver of any violation of this Agreement or failure to enforce any provision of this Agreement shall not constitute a waiver of PPD’s rights with respect to other or
future violations of this Agreement. Any waiver must be in a writing signed by PPD. 
 14. Binding Effect. This Agreement
shall be binding upon and inure to the benefit of the parties, their heirs, successors and assigns. 
 15. Entire
Agreement. This Agreement contains the entire agreement of the parties with respect to the matters set forth herein and supercedes all previous negotiations and discussions, agreements and understandings regarding such matters, with the
exception of Employee’s Proprietary Information and Inventions Agreement and any employment or severance agreement to which Employee and PPD are parties. In the event of any conflict between this Agreement and any other PPD agreements, the
terms of the agreement which are most restrictive shall control. It is understood that this Agreement does not constitute an express or implied employment contract for any definite period of time and that, absent a written agreement between PPD and
Employee, Employee’s employment with PPD is “at will” meaning that either PPD or Employee can end the employment relationship at any time, with or without cause. 

16. Execution in Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be deemed an
original and all of which taken together shall constitute one and the same instrument. 
 IN WITNESS WHEREOF, the parties have
executed this Agreement, effective as of the date set forth herein. 
  

			
	PHARMACEUTICAL PRODUCT DEVELOPMENT, INC.
		
	By:	 	 /s/ Fred N. Eshelman

	Name:	 	 Fred N. Eshelman

	Title:	 	 Executive Chairman

	
	 /s/ Raymond H. Hill

	Raymond H. Hill, Employee

  
 4

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