Document:

Placement Agency Agreement

 EXHIBIT 10.1 
  
 PLACEMENT AGENCY AGREEMENT 
  
 June 13, 2003 
  
 Roth Capital Partners, LLC 
 24 Corporate Plaza 
 Newport Beach, CA 92660 
  
 Ladies and Gentlemen:

  
 Introductory.    Targeted Genetics
Corporation, a Washington corporation (the “Company”), proposes, subject to the terms and conditions herein, to issue and sell an aggregate of up to $20,000,000 in shares (the “Shares”) of its common stock, $0.01 par value per
share (the “Common Stock”), in one or more series directly to various investors (collectively, the “Investors”). The Shares are sometimes herein collectively referred to as the “Securities.” 
  
 The Company hereby confirms its agreement with the Placement Agent as
follows: 
  

	Section	 	1.     Agreement to Act as Placement Agent. 

  
 (a)          On the basis of the representations, warranties and
agreements of the Company herein contained, and subject to all the terms and conditions of this Agreement between the Company and Roth Capital Partners, LLC (“Roth Capital”), Roth Capital shall be the Company’s exclusive placement
agent (in such capacity, the “Placement Agent”), on a reasonable efforts basis, in connection with the issuance and sale by the Company of the Securities in one or more proposed takedowns from shelf Registration Statement No. 333-74976, or
other registration statement(s) filed or to be filed to accomplish the takedowns (collectively the “Registration Statement”), with the terms of each offering to be subject to market conditions and negotiations between the Company, Roth
Capital and the prospective Investors (each takedown shall be referred to herein as an “Offering”). As compensation for services rendered, and provided that any of the Securities are sold to Investors in any Offering, on the Closing Date
(as defined below) of each Offering, the Company shall pay to the Placement Agent an amount equal to 7% of the gross proceeds received by the Company from the sale of the Securities. 
  
 This Agreement shall not give rise to any commitment by the Placement Agent to purchase any of the Securities, and the
Placement Agent shall have no authority to bind the Company. The Placement Agent shall act on a reasonable efforts basis and does not guarantee that it will be able to raise new capital in any prospective Offering. The Company acknowledges that any
advice given by Roth Capital to the Company is solely for benefit and use of the Board of Directors of the Company and may not be used, reproduced, disseminated, quoted or referred to, without the Placement Agent’s prior written consent. The
Placement Agent may retain other brokers or dealers to act as sub-agents on its behalf in connection with any Offering. 
  
 (b)         The term of Roth Capital’s exclusive engagement will be three months; however, either party
may terminate the engagement at any time upon 10 days written notice to the other party. Upon termination, Roth Capital will be entitled to collect all fees earned and expenses incurred through the date of termination, and the amounts described in
the next sentence, if applicable. If Roth Capital’s exclusive engagement is terminated prior to the expiration of the three month period beginning on the date hereof (the “Exclusive Term”), any person to whom Placement Agent
introduced the Company, or with which we have discussions or negotiations about an investment in the Company during the term of this Agreement, purchases securities from the Company, the Company agrees to pay to Placement Agent upon the closing of
such transaction a cash fee in the amount that would otherwise have been payable to the Placement Agent had such transaction occurred during the term. The Placement Agent shall provide the Company with a list of investors as described in this
section within five (5) business days of termination of this Agreement. Nothing in this Agreement shall be construed to limit the ability of Roth Capital or its affiliates to pursue, investigate, analyze, invest in, or engage in investment banking,
financial advisory or any other business relationship with entitles or persons other than the Company. 

	Section	 	2.     Representations, Warranties and Agreements of the Company. 

  
 I.            The Company hereby represents, warrants and
covenants to the Placement Agent as of the date hereof, and as of the Closing Date of each Offering, as follows: 
  
 (a)          Securities Law Filings.  The Company meets the requirements for use of
Form S-3 under the Securities Act of 1933, as amended (the “Act”), and has filed with the Securities and Exchange Commission (the “Commission”) the Registration Statement on such Form S-3 (Registration File No. 333-74976), which
has become effective on October 16, 2002, for the registration under the Act of the Securities. Such registration statement meets the requirements set forth in Rule 415(a)(1)(x) under the Act and complies in all other material respects with said
Rule. The Company will file with the Commission pursuant to Rule 424(b) under the Act a supplement to the form of prospectus included in such registration statement relating to a placement of the Securities and the plan of distribution thereof and
has advised the Placement Agent of all further material information (financial and other) with respect to the Company to be set forth therein. Such registration statement, including the exhibits thereto, as amended at the date of this Agreement, is
hereinafter called the “Registration Statement”; such prospectus in the form in which it appears in the Registration Statement is hereinafter called the “Base Prospectus”; and the supplemented form of prospectus, in the form in
which it will be filed with the Commission pursuant to Rule 424(b) is hereinafter called a “Prospectus Supplement.” Any reference herein to the Registration Statement, the Base Prospectus or the Prospectus Supplement shall be deemed to
refer to and include the documents incorporated by reference therein (the “Incorporated Documents”) pursuant to Item 12 of Form S-3 which were filed under the Securities Exchange Act of 1934, as amended (the “Exchange Act”), on
or before the date of this Agreement, or the issue date of the Base Prospectus or Prospectus Supplement, as the case may be; and any reference herein to the terms “amend,” “amendment” or “supplement” with respect to the
Registration Statement, the Base Prospectus or the Prospectus Supplement shall be deemed to refer to and include the filing of any document under the Exchange Act after the date of this Agreement, or the issue date of the Base Prospectus or the
Prospectus Supplement, as the case may be, deemed to be incorporated therein by reference. All references in this Agreement to financial statements and schedules and other information which is “contained,” “included” or
“stated” in the Registration Statement or the Prospectus Supplement (and all other references of like import) shall be deemed to mean and include all such financial statements and schedules and other information which is or is deemed to be
incorporated by reference in the Registration Statement or the Prospectus Supplement, as the case may be. 
  
 (b)         No Stop Order.  No stop order suspending the effectiveness of the Registration
Statement or the use of the Base Prospectus or the Prospectus Supplement has been issued, and no proceeding for any such purpose is pending or has been initiated or, to the Company’s knowledge, is threatened by the Commission. 
  
 (c)          Compliance
with Applicable Regulations.  The Registration Statement (and any further documents to be filed with the Commission) contains all exhibits and schedules as required by the Act. Each of the Registration Statement and any post-effective
amendment thereto, at the time it became effective, complied in all material respects with the Act and the Exchange Act and the applicable rules and regulations of the Commission thereunder and did not and, as amended or supplemented, if applicable,
will not, contain any untrue statement of a material fact or omit to state a material fact 

  

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required to be stated therein or necessary to make the statements therein not misleading. Each of the Base Prospectus and the Prospectus Supplement, as of
its respective date, complied in all material respects with the Act and the Exchange Act and the applicable rules and regulations of the Commission thereunder. Each of the Base Prospectus and the Prospectus Supplement, as amended or supplemented,
did not and will not contain as of the effective date thereof any untrue statement of a material fact or omit to state a material fact necessary in order to make the statements therein, in light of the circumstances under which they were made, not
misleading. The Incorporated Documents, when they were filed with the Commission, conformed in all material respects to the requirements of the Exchange Act and the applicable rules and regulations of the Commission thereunder, and none of such
documents, when they were filed with the Commission, contained any untrue statement of a material fact or omitted to state a material fact necessary to make the statements therein not misleading; and any further documents so filed and incorporated
by reference in the Base Prospectus or Prospectus Supplement, when such documents are filed with the Commission, will conform in all material respects to the requirements of the Exchange Act and the applicable rules and regulations of the Commission
thereunder, as applicable, and will not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements therein not misleading. Notwithstanding the foregoing, the Company makes no representations or
warranties as to the information contained in or omitted from the Prospectus Supplement or any amendment thereof or supplement thereto in reliance upon and in conformity with information furnished in writing to the Company by or on behalf of the
Placement Agent specifically for use in the Registration Statement or the Prospectus Supplement. No post-effective amendment to the Registration Statement reflecting any facts or events arising after the effective date thereof which represent,
individually or in the aggregate, a fundamental change in the information set forth therein is required to be filed with the Commission. 
  
 (d)          Reports and Documents, etc.  There are no documents required to be filed
with the Commission in connection with the transaction contemplated hereby that (x) have not been filed as required pursuant to the Act or (y) will not be filed within the requisite time period. There are no contracts or other documents required to
be described in the Prospectus Supplement, or to be filed as exhibits or schedules to the Registration Statement, which have not been described or filed as required. 
  
 (e)          Offering Materials Furnished to the Placement
Agent.  The Company has delivered, or will as promptly as practicable deliver, to the Placement Agent complete conformed copies of the Registration Statement and of each consent and certificate of experts filed as a part thereof, and
conformed copies of the Registration Statement (without exhibits) and the Base Prospectus and the Prospectus Supplement, as amended or supplemented, in such quantities and at such places as the Placement Agent reasonably request. 
  
 (f)          Distribution of Offering Material.  The Company has not distributed and will not distribute, prior to the completion of the distribution of the Securities, any
offering material in connection with the offering and sale of the Securities other than the Base Prospectus and the Prospectus Supplement or the Registration Statement and copies of the documents incorporated by reference therein. For the avoidance
of doubt, any other material prepared and distributed solely by the Placement Agent is not deemed to be distributed by the Company for purposes of this paragraph (f). 
  
 (g)          The Placement Agency Agreement.  This
Agreement has been duly authorized, executed and delivered by, and is a valid and binding agreement of, the Company, enforceable against the Company in accordance with its terms, except as rights to indemnification and contribution hereunder may be
limited by applicable law and except as the enforcement hereof may be limited by bankruptcy, insolvency, reorganization, moratorium or other similar laws relating to or affecting the rights and remedies of creditors or by general equitable
principles. 
  

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 (h)         No Material Adverse
Change.  Subsequent to the respective dates as of which information is given in the Base Prospectus and in any Prospectus Supplement: (i) there has been no material adverse change or effect, or any development that could reasonably be
expected to result in a material adverse change or effect, in the condition, financial or otherwise, or in the earnings, business, operations or prospects, whether or not arising from transactions in the ordinary course of business, of the Company
and the Subsidiaries (as defined) taken as a whole (any such change or effect, where the context so requires, is called a “Material Adverse Change” or a “Material Adverse Effect”); (ii) the Company and the Subsidiaries have not
incurred any material liability or obligation, indirect, direct or contingent, not in the ordinary course of business nor entered into any material transaction or agreement not in the ordinary course of business; and (iii) there has been no dividend
or distribution of any kind declared, paid or made by the Company on any class of capital stock or repurchase or redemption by the Company of any class of capital stock. 
  
 (i)          Independent Accountants.  Ernst & Young
LLP, who have expressed their opinion with respect to the annual financial statements (which term as used in this Agreement includes the related notes and schedules thereto) and supporting schedules filed with the Commission as a part of the
Registration Statement and incorporated by reference in the Prospectus, are independent public or certified public accountants as required by the Act and the Exchange Act. 
  
 (j)          Preparation of the Financial
Statements.  The financial statements filed with the Commission as a part of the Registration Statement or included or incorporated by reference in the Base Prospectus or Prospectus Supplement present fairly the financial position of
the Company and its consolidated subsidiaries as of and at the dates indicated and the results of their operations and cash flows for the periods specified therein. The supporting exhibits and schedules included in the Registration Statement, if
any, present fairly the information required to be stated therein subject to the normal year-end adjustments which are not expected to be material in amount. The assumptions used in preparing the pro form financial statements provide a reasonable
basis for presenting the significant effects attributable to the transactions or events described therein, the related pro forma adjustments comply with Regulation G and give appropriate effect to the assumptions and the pro forma columns and
reconciliations therein reflect the proper application of adjustments to the corresponding historical financial statements. Such financial statements and supporting schedules, if any, have been prepared in conformity with generally accepted
accounting principles as applied in the United States (“GAAP”), as applicable, applied on a consistent basis throughout the periods involved, except as may be expressly stated in the related notes thereto and comply in all material
respects with the Securities Act, the Exchange Act and the applicable rules and regulations of the Commission thereunder. No other financial statements or supporting schedules or exhibits are required by the Act or the rules and regulations of the
Commission thereunder to be included in the Registration Statement or the Prospectus Supplement. 
  
 (k)         Stock Exchange Listing.  The Common Stock (including the Shares) is registered
under the Exchange Act and is listed on the Nasdaq SmallCap Market, and the Company has taken no action designed to, or likely to have the effect of terminating the registration of the Common Stock under the Exchange Act or delisting or suspending
from trading the Common Stock from Nasdaq, nor has the Company received any information suggesting that the Commission or the National Association of Securities Dealers, LLC (“NASD”) is contemplating terminating or suspending such
registration or listing. 
  
 (l)          No Transfer Taxes or Other Fees.  There are no transfer Taxes or other similar fees or charges under United States law or the laws of any state or any political
subdivision thereof, required to be paid in connection with the execution and delivery of this Agreement or the issuance and sale by the Company of the Securities. 
  

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 (m)        No Price Stabilization or
Manipulation.  The Company has not taken and will not take, directly or indirectly, any action designed to or that could reasonably be expected to cause or result in stabilization or manipulation of the price of the Common Stock to
facilitate the sale or resale of the Securities. 
  
 (n)         Blue Sky; NASD Matters.  The Securities have been or will be qualified for sale under the securities laws of such jurisdictions (United States and foreign) as the
Placement Agent and the Investors determine, or are or will be exempt from the qualification and broker-dealer requirements of such jurisdictions. With respect to the compensation to be paid to the Placement Agent under this Agreement, such
compensation arrangements are exempt from the filing requirements of NASD Rule 2710 because the Company has met and continues to meet the pre-1992 eligibility requirements for the use of the Registration Statement on Form S-3 in connection with the
Offering(s) contemplated thereby and hereby. 
  
 (o)         No Actions, Suits or Proceedings.  No action, suite or proceeding by or before any foreign, federal, state or local court or governmental agency, authority or body or
any arbitrator involving the Company or any Subsidiary, as the case may be, or any of its property is pending or, to the best knowledge of the Company, threatened that if adversely determined: (i) could reasonably be expected to have a Material
Adverse Effect on the performance of this Agreement or the consummation of any of the transactions contemplated hereby; or (ii) could reasonably be expected to result in a Material Adverse Change 
  
 (p)         Ownership of
Assets.  The Company and the Subsidiaries own or have valid rights to use or occupy all material assets, including intellectual property assets, necessary to conduct the business described in the Base Prospectus and Prospectus
Supplement, and no material right is expected to expire, terminate or be disposed of in the foreseeable future, except as disclosed therein. The Company has not received any notice of, and neither the Company nor any subsidiary has knowledge of, any
infringement of or conflict with the rights of others, except where the loss of any such right would not be reasonably likely to have a Material Adverse Effect. 
  

(q)         Legal Compliance.  Each of the Company and the Subsidiaries are in compliance
with all applicable laws, rules and regulations, including with respect to the payment of taxes, the environment, employee benefit plans, and payments to officials or candidates for governmental office, and maintains permits, licenses, or other
authorizations required by law or its business, except where the failure to be in compliance or the lack of an authorization is not reasonably likely to have a Material Adverse Effect. 
  
 II.         The Company agrees that the Placement Agent may rely upon, and is
an express third beneficiary of, the representations and warranties, and applicable covenants, set forth in any subscription or purchase agreement with Investors in any Offering. 
  
 III.        Any certificate signed by an officer of the Company and delivered to the
Placement Agent or the Investors in connection herewith or in connection with any Offering shall be deemed to be a representation and warranty by the Company to the Placement Agent as to the matters set forth therein. 
  
 Section 3.      Delivery and Payment. 

 
 On the Closing Date of each Offering, each of the Investors will deposit
into an account with the escrow agent designated by the Company and the Investors (the “Escrow Agent”) by the Company an amount equal to the price per Share as shown on the cover page of the applicable Prospectus Supplement multiplied by
the number of Shares purchased by it. At 10:00 a.m., California time or at such other time on the date of each closing of a takedown, as may be agreed upon by the Company and the Placement Agent (each a “Closing Date”), the Company shall
deliver certificates in definitive form evidencing the Shares, against payment therefor, to the Escrow Agent. The certificates evidencing the Shares shall be registered in such names and in such denominations as the Placement Agent or the Investors
shall request by written notice to the Company. For the purpose of expedited checking and packaging of the certificates for the Shares, the Company agrees to make such certificates available for inspection at the offices of the Placement Agent at
least 24 hours prior to the Closing Date. Each closing (the “Closing”) shall take place at the Company’s principal executive offices or at the offices of the Company’s legal counsel. All actions taken at the Closing shall be
deemed to have occurred simultaneously. 
  

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	Section	 	4.      Covenants of the Company. 

  

The Company further covenants to and agrees with the Placement Agent as follows: 
  
 (a)          Registration Statement Matters.  The Company
agrees to advise you promptly after it receives notice thereof, of the time when any amendment to the Registration Statement has been filed or becomes effective or any supplement to the Prospectus Supplement or any amended Prospectus Supplement has
been filed and to furnish you with copies thereof; to file promptly all reports and any definitive proxy or information statements required to be filed by the Company with the Commission pursuant to Section 13(a), 14 or 15(d) of the Exchange Act
subsequent to the date of the Prospectus Supplement and for so long as the delivery of a prospectus is required in connection with the offering or sale of the Securities; to advise you, promptly after it receives notices thereof (i) of any request
by the Commission to amend the Registration Statement or to amend or supplement the Prospectus Supplement or for additional information and (ii) of the issuance by the Commission, of any stop order suspending the effectiveness of the Registration
Statement or any post-effective amendment thereto or any order directed at any Incorporated Document or any amendment or supplement thereto or any order preventing or suspending the use of the Base Prospectus or the Prospectus Supplement or any
amendment or supplement thereto or any post-effective amendment to the Registration Statement, of the suspension of the qualification of the Securities for offering or sale in any jurisdiction, of the institution or threatening of any proceeding for
any such purpose, or of any request by the Commission for the amending or supplementing of the Registration Statement or Prospectus Supplement or for additional information; and, in the event of the issuance of any stop order or of any order
preventing or suspending the use of the Base Prospectus or Prospectus Supplement or suspending any such qualification, promptly to use its reasonable best efforts to obtain the withdrawal of such order. 
  
 (b)          Blue Sky
Compliance.  The Company will cooperate with the Placement Agent and the Investors in endeavoring to qualify the Securities for sale under the securities laws of such jurisdictions (United States and foreign) as the Placement Agent and
the Investors may reasonably request and will make such applications, file such documents, and furnish such information as may be reasonably required for that purpose, provided the Company shall not be required to qualify as a foreign corporation or
to file a general consent to service of process in any jurisdiction where it is not now so qualified or required to file such a consent, and provided further that the Company shall not be required to produce any new disclosure document other than
the Prospectus Supplement. The Company will, from time to time, prepare and file such statements, reports and other documents as are or may be required to continue such qualifications in effect for so long a period as the Placement Agent may
reasonably request for distribution of the Securities. 
  
 (c)          Amendments and Supplements to the Prospectus Supplement and Other Securities Act Matters.  The Company will comply with the Act and the Exchange Act, and the
rules and regulations of the Commission thereunder, so as to permit the completion of the distribution of the Securities as contemplated in this Agreement, the Base Prospectus and any Prospectus Supplement. If during the period in which a prospectus
is required by law to be delivered by a Placement Agent or a dealer in connection with the distribution of Securities contemplated by the Base Prospectus or any Prospectus 

  

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Supplement, any event shall occur as a result of which, in the judgment of the Company or in the reasonable opinion of the Placement Agent or counsel for the
Placement Agent, it becomes necessary to amend or supplement the Base Prospectus or any Prospectus Supplement in order to make the statements therein, in the light of the circumstances existing at the time the Prospectus Supplement is delivered to a
purchaser, not misleading, or, if it is necessary at any time to amend or supplement the Base Prospectus or any Prospectus Supplement to comply with any law, the Company promptly will prepare and file with the Commission, and furnish at its own
expense to the Placement Agent and to dealers, an appropriate amendment to the Registration Statement or supplement to the Base Prospectus or any Prospectus Supplement so that the Prospectus Supplement as so amended or supplemented will not, in the
light of the circumstances when it is so delivered, be misleading, or so that the Base Prospectus or any Prospectus Supplement will comply with such law. Before amending the Registration Statement or supplementing the Base Prospectus in connection
with each Offering, the Company will furnish you with a copy of such proposed amendment or supplement and will not file such amendment or supplement to which you reasonably object. 
  
 (d)          Copies of any Amendments and Supplements to the Prospectus
Supplement.  The Company agrees to furnish the Placement Agent, without charge, during the period beginning on the date hereof and ending on the later of the Closing Date of each Offering or such date, as in the opinion of counsel for
the Placement Agent, the Prospectus Supplement are no longer required by law to be delivered in connection with sales by a Placement Agent or dealer (the “Prospectus Delivery Period”), as many copies of the Base Prospectus and Prospectus
Supplement and any amendments and supplements thereto (including any Incorporated Documents) as the Placement Agent may reasonably request. 
  
 (e)          Use of Proceeds.  The Company shall apply the net proceeds from the sale
of the Securities sold by it in the manner described under the caption “Use of Proceeds” in each Prospectus Supplement. 
  
 (f)          Transfer Agent.  The Company shall engage and maintain, at its expense, a
registrar and transfer agent for the Common Stock. 
  
 (g)          Earnings Statement.  As soon as practicable and in accordance with applicable requirements under the Act, but in any event not later than 18 months after the
Closing Date of each Offering, the Company will make generally available to its security holders and to the Placement Agent an earnings statement, covering a period of at least 12 consecutive months beginning after the Closing Date, that satisfies
the provisions of Section 11(a) and Rule 158 under the Act. 
  
 (h)          Periodic Reporting Obligations.  During the Prospectus Delivery Period, the Company shall duly file, on a timely basis, with the Commission and the Nasdaq Small
Cap Market all reports and documents required to be filed under the Exchange Act within the time periods and in the manner required by the Exchange Act. 
  
 (i)          Additional Documents.  The Company will enter into any subscription,
purchase or other customary agreements as the Placement Agent or the Investors deem necessary or appropriate to consummate each Offering, all of which will be in form and substance reasonably acceptable to the Placement Agent and the Investors. The
Company agrees that the Placement Agent may rely upon, and is a third party beneficiary of, the representation and warranties, and applicable covenants, set forth in any such purchase, subscription or other agreement with Investors in each Offering.

  

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 Section 5.        Conditions of the Obligations of the Placement Agent.

  
 The obligations of the Placement Agent hereunder shall be
subject to the accuracy of the representations and warranties on the part of the Company set forth in Section 2 as of the date hereof and as of the Closing Date of each Offering as though then made, to the timely performance by the Company of its
covenants and other obligations hereunder on and as of such dates, and to each of the following additional conditions: 
  
 (a)          Compliance with Registration Requirements; No Stop Order; No Objection from the
NASD.  Each Prospectus Supplement shall have been duly filed with the Commission in accordance with Rule 424(b); no stop order suspending the effectiveness of the Registration Statement or any part thereof shall have been issued and no
proceeding for that purpose shall have been initiated or threatened by the Commission; no order preventing or suspending the use of any Prospectus Supplement shall have been issued and no proceeding for that purpose shall have been initiated or
threatened by the Commission; no order having the effect of ceasing or suspending the distribution of the Securities or any other securities of the Company shall have been issued by any securities commission, securities regulatory authority or stock
exchange and no proceedings for that purpose shall have been instituted or shall be pending or, to the knowledge of the Company, contemplated by any securities commission, securities regulatory authority or stock exchange; all requests for
additional information on the part of the Commission shall have been complied with; and the NASD shall have raised no objection to the fairness and reasonableness of the placement agency terms and arrangements. 
  
 (b)          Corporate
Proceedings.  All corporate proceedings and other legal matters in connection with this Agreement, the Registration Statement and each Prospectus Supplement, and the registration, authorization, issue, sale and delivery of the
Securities, shall have been reasonably satisfactory to the Placement Agent’s counsel, and such counsel shall have been furnished with such papers and information as they may reasonably have requested to enable them to pass upon the matters
referred to in this Section 5. 
  
 (c)          No Material Adverse Change.  Subsequent to the execution and delivery of this Agreement and prior to each Closing Date, there shall not have occurred any
Material Adverse Change or Material Adverse Effect, which, in your sole judgment, makes it impracticable or inadvisable to proceed with the public offering of the Securities on the terms and in the manner contemplated by the applicable Prospectus
Supplement. 
  
 (d)          Opinion of Counsel for the Company.  You shall have received on the Closing Date of each Offering, and the Company shall cause to be delivered to you an opinion
of legal counsel to the Company in customary form, dated the Closing Date, addressed to the Placement Agent. 
  
 (e)          [RESERVED] 
  
 (f)          Accountants’ Comfort Letter.  You shall
have received on each Closing Date and the Company shall cause to be delivered to you, a letter from Ernst & Young LLP (or the Company’s other applicable independent auditors), addressed to the Placement Agent, dated as of each Closing
Date, in customary form. The letter shall not disclose any change in the condition (financial or otherwise), earnings, operations, business or prospects of the Company from that set forth in the Registration Statement or the applicable Prospectus
Supplement, which, in your sole judgment, is material and adverse and that makes it, in your sole judgment, impracticable or inadvisable to proceed with the public offering of the Securities as contemplated by such Prospectus Supplement. 

 
 (g)          Officers’ Certificate.  You shall have received on each Closing Date a certificate of the Company, dated as of each Closing Date signed by the Chief
Executive Officer and Chief Financial Officer of the Company, to the effect that, and you shall be satisfied that: 
  

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 (i)          The representations and warranties of the
Company in this Agreement are true and correct, as if made on and as of the Closing Date, and the Company has complied with all the agreements and satisfied all the conditions on its part to be performed or satisfied at or prior to each Closing
Date; 
  
 (ii)         No stop order suspending the effectiveness of the Registration Statement or the use of the Base Prospectus or the Prospectus Supplement has been issued and no proceedings for that
purpose have been instituted or are pending or, to the Company’s knowledge, threatened under the Act; no order having the effect of ceasing or suspending the distribution of the Securities or any other securities of the Company has been issued
by any securities commission, securities regulatory authority or stock exchange in the United States and no proceedings for that purpose have been instituted or are pending or, to the knowledge of the Company, contemplated by any securities
commission, securities regulatory authority or stock exchange in the United States; 
  
 (iii)        When the Registration Statement became effective and at all times subsequent thereto up to the delivery of such certificate, the Registration Statement, the Base
Prospectus and each Prospectus Supplement and any amendments or supplements thereto, and Incorporated Documents, when such documents became effective or were filed with the Commission, contained all material information required to be included
therein by the Act and the Exchange Act and the applicable rules and regulations of the Commission thereunder, as the case may be, and in all material respects conformed to the requirements of the Act and the Exchange Act and the applicable rules
and regulations of the Commission thereunder, as the case may be, and the Registration Statement and the Base Prospectus and the Prospectus Supplement, and any amendments or supplements thereto, did not and do not include any untrue statement of a
material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading (provided, however, that the preceding
representations and warranties contained in this paragraph (iii) shall not apply to any statements or omissions made in reliance upon and in conformity with information furnished in writing to the Company by the Placement Agent expressly for use
therein) and, since the effective date of the Registration Statement, there has occurred no event required by the Act and the rules and regulations of the Commission thereunder to be set forth in an amended or supplemented Prospectus Supplement
which has not been so set forth; 
  
 (iv)        Subsequent to the respective dates as of which information is given in the Registration Statement, the Base Prospectus and each Prospectus Supplement, there has not been: (a) any Material
Adverse Change; (b) any transaction that is material to the Company and the Subsidiaries taken as a whole, except transactions entered into in the ordinary course of business; (c) any obligation, direct or contingent, that is material to the Company
and the Subsidiaries taken as a whole, incurred by the Company or any Subsidiary, except obligations incurred in the ordinary course of business; (d) any material change in the capital stock (except changes thereto resulting from the exercise of
outstanding stock options or warrants) or outstanding indebtedness of the Company or any Subsidiary; (e) any dividend or distribution of any kind declared, paid or made on the capital stock of the Company; or (f) any loss or damage (whether or not
insured) to the property of the Company or any Subsidiary which has been sustained or will have been sustained which has a Material Adverse Effect; and 
  
 (v)         The Company has been subject to continuous disclosure requirements of the Exchange Act for a
period of at least 12 calendar months immediately preceding the filing of the Registration Statement, has timely filed all reports required of it to be filed under the Exchange Act during the past 12 calendar months and the portion of the month in
which the Registration Statement was filed, and as of the date of the Base Prospectus and each Prospectus Supplement is currently in compliance with such obligations; and the Company has an aggregate market value of the public float of its
outstanding Common Stock of U.S. $75 million or more. 
  

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 (h)         Stock Exchange Listing.  The
Common Stock (and the Shares) is registered under the Exchange Act and is or will as of the Closing Date be listed on the Nasdaq SmallCap Market, and the Company has taken no action designed to, or likely to have the effect of terminating the
registration of the Shares under the Exchange Act or delisting or suspending from trading the Shares from Nasdaq, nor has the Company received any information suggesting that the Commission or the NASD is contemplated terminating such registration
or listing. 
  
 (i)          Compliance with Prospectus Delivery Requirements.  The Company shall have complied with the provisions of Sections 3 and 4(c) and (d) with respect to the
furnishing of Prospectus Supplements. 
  
 (j)          Additional Documents.  On or before each Closing Date, the Placement Agent and counsel for the Placement Agent shall have received such information and
documents as they may reasonably require for the purposes of enabling them to pass upon the issuance and sale of the Securities as contemplated herein, or in order to evidence the accuracy of any of the representations and warranties, or the
satisfaction of any of the conditions or agreements, herein contained. 
  
 If any condition specified in this Section 5 is not satisfied when and as required to be satisfied, this Agreement may be terminated by the Placement Agent by notice to the Company at any time on or prior to the Closing Date, which
termination shall be without liability on the part of any party to any other party, except that Section 6 (Payment of Expenses), Section 7 (Reimbursement of Placement Agent’s Expenses), Section 8 (Indemnification and Contribution) and Section
10 (Representations and Indemnities to Survive Delivery) shall at all times be effective and shall survive such termination. 
  
 Section 6.        Payment of Expenses. 
  
 The Company agrees to pay all costs, fees and expenses incurred in connection with the performance of its obligations
hereunder and in connection with the transactions contemplated hereby, including without limitation: (i) all expenses incident to the issuance, delivery and qualification of the Securities (including all printing and engraving costs); (ii) all fees
and expenses of the registrar and transfer agent of the Common Stock; (iii) all necessary issue, transfer and other stamp taxes in connection with the issuance and sale of the Securities; (iv) all fees and expenses of the Company’s counsel,
independent public or certified public accountants and other advisors; (v) all costs and expenses incurred in connection with the preparation, printing, filing, shipping and distribution of the Registration Statement (including financial statements,
exhibits, schedules, consents and certificates of experts), the Base Prospectus and each Prospectus Supplement, and all amendments and supplements thereto, and this Agreement; (vi) all filing fees, reasonable attorneys’ fees and expenses
incurred by the Company or the Placement Agent in connection with qualifying or registering (or obtaining exemptions from the qualification or registration of) all or any part of the Securities for offer and sale under the state securities or blue
sky laws or the securities laws of any other country, and, if requested by the Placement Agent, preparing and printing a “Blue Sky Survey,” an “International Blue Sky Survey” or other memorandum, and any supplements thereto,
advising the Placement Agent of such qualifications, registrations and exemptions; (vii) the filing fees incident to, and the reasonable fees and expenses of counsel for the Placement Agent in connection with, the review and approval by the NASD of
the Placement Agent’s participation in the offering and distribution of the Securities; (viii) the fees and expenses associated with including the Shares on the Nasdaq SmallCap Market; (ix) all costs and expenses incident to the travel and
accommodation of the Company’s employees on the “roadshow,” if any; and (x) all other fees, costs and expenses referred to in Part II of the Registration Statement. 
  

 10 

 Section 7.       Reimbursement of Placement Agent’s Expenses. 

 
 Whether or not this Agreement is terminated, and whether or not the sale
to the Investors of the Securities on any Closing Date is consummated, the Company agrees to reimburse the Placement Agent, upon demand, for all reasonable and documented out-of-pocket expenses that shall have been reasonably incurred by the
Placement Agent in connection with the proposed purchase and the offering and sale of the Securities, including but not limited to printing expenses, travel and accommodation expenses, postage, facsimile and telephone charges. 
  
 Section 8.       Indemnification and Contribution.

  
 (a)          Indemnification of the Placement Agent.  The Company agrees to indemnify and hold harmless the Placement Agent, its officers and employees, and each person, if
any, who controls the Placement Agent within the meaning of the Act and the Exchange Act against any loss, claim, damage, liability or expense, as incurred, to which such Placement Agent or such controlling person may become subject, under the Act,
the Exchange Act, or other federal or state statutory law or regulation, or at common law or otherwise (including in settlement of any litigation, if such settlement is effected with the written consent of the Company, which consent shall not be
unreasonably withheld), insofar as such loss, claim, damage, liability or expense (or actions in respect thereof as contemplated below) arises out of or is based: (i) upon any untrue statement or alleged untrue statement of a material fact contained
in the Registration Statement, or any amendment thereto, or the omission or alleged omission therefrom of a material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances under which they
were made, not misleading; or (ii) upon any untrue statement or alleged untrue statement of a material fact contained in the Base Prospectus or the Prospectus Supplement (or any amendment or supplement thereto), or the omission or alleged omission
therefrom of a material fact necessary in order to make the statements therein, in the light of the circumstances under which they were made, not misleading; or (iii) in whole or in part upon any inaccuracy in the representations and warranties of
the Company contained herein; or (iv) in whole or in part upon any failure of the Company to perform its obligations hereunder or under law; or (v) any act or failure to act or any alleged act or failure to act by any Placement Agent in connection
with, or relating in any manner to, the Securities or the offering contemplated hereby, and which is included as part of or referred to in any loss, claim, damage, liability or action arising out of or based upon any matter covered by clause (i),
(ii), (iii) or (iv) above, provided that the Company shall not be liable under this clause (v) to the extent that a court of competent jurisdiction shall have determined by a final judgment that such loss, claim, damage, liability or action resulted
directly from any such acts or failures to act undertaken or omitted to be taken by any Placement Agent through its bad faith or willful misconduct; and to reimburse such Placement Agent and each such controlling person for any and all expenses
(including the reasonable fees and disbursements of counsel chosen by Roth Capital) as such expenses are reasonably incurred by such Placement Agent or such controlling person in connection with investigating, defending, settling, compromising or
paying any such loss, claim, damage, liability, expense or action; provided, however, that the foregoing indemnity agreement shall not apply to any loss, claim, damage, liability or expense to the extent, but only to the extent, arising out of or
based upon any untrue statement or alleged untrue statement or omission or alleged omission made in reliance upon and in conformity with written information furnished to the Company by any Placement Agent expressly for use in the Registration
Statement, the Base Prospectus or the Prospectus Supplement (or any amendment or supplement thereto). 
  
 (b)          Indemnification of the Company, its Directors and Officers.  The Placement
Agent agrees to indemnify and hold harmless the Company, each of its directors, each of its officers who signed the Registration Statement and each person, if any, who controls the Company within the meaning of the Act 
  

 11 

 or the Exchange Act, against any loss, claim, damage, liability or expense, as incurred, to which the Company, or any
such director, officer or controlling person may become subject, under the Act, the Exchange Act, or other federal, state statutory law or regulation, or at common law or otherwise (including in settlement of any litigation, if such settlement is
effected with the written consent of such Placement Agent), insofar as such loss, claim, damage, liability or expense (or actions in respect thereof as contemplated below) arises out of or is based upon any untrue or alleged untrue statement of a
material fact contained in any Prospectus Supplement (or any amendment or supplement thereto), or arises out of or is based upon the omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the
statements therein not misleading, in each case to the extent, but only to the extent, that such untrue statement or alleged untrue statement or omission or alleged omission was made in such Prospectus Supplement (or any amendment or supplement
thereto), in reliance upon and in conformity with written information furnished to the Company by such Placement Agent expressly for use therein and to reimburse the Company, or any such director, officer or controlling person for any legal and
other expense reasonably incurred by the Company, or any such director, officer or controlling person in connection with investigating, defending, settling, compromising or paying any such loss, claim, damage, liability, expense or action. The
indemnity agreement set forth in this Section 8(b) shall be in addition to any liabilities that the Placement Agent may otherwise have. 
  
 (c)          Information Provided by the Placement Agent.  The Company and each person,
if any, who controls the Company within the meaning of the Act or the Exchange Act, hereby acknowledges that the only information that the Placement Agent will furnish to the Company expressly for use in any Prospectus Supplement (or any amendment
or supplement thereto) are the statements regarding the Placement Agent set forth under the caption “Plan of Distribution” in the Prospectus Supplement. 
  
 (d)          Notifications and Other Indemnification
Procedures.  Promptly after receipt by an indemnified party under this Section 8 of notice of the commencement of any action, such indemnified party will, if a claim in respect thereof is to be made against an indemnifying party under
this Section 8, notify the indemnifying party in writing of the commencement thereof, but the omission so to notify the indemnifying party will not relieve it from any liability, which it may have to any indemnified party for contribution to the
extent it is not prejudiced as a proximate result of such failure. In case any such action is brought against any indemnified party and such indemnified party seeks or intends to seek indemnity from an indemnifying party, the indemnifying party will
be entitled to participate in, and, to the extent that it shall elect, jointly with all other indemnifying parties similarly notified, by written notice delivered to the indemnified party promptly after receiving the aforesaid notice from such
indemnified party, to assume the defense thereof with counsel reasonably satisfactory to such indemnified party; provided, however, if the defendants in any such action include both the indemnified party and the indemnifying party and the
indemnified party shall have reasonably concluded that a conflict may arise between the positions of the indemnifying party and the indemnified party in conducting the defense of any such action or that there may be legal defenses available to it
and/or other indemnified parties which are different from or additional to those available to the indemnifying party, the indemnified party or parties shall have the right to select separate counsel to assume such legal defenses and to otherwise
participate in the defense of such action on behalf of such indemnified party or parties. Upon receipt of notice from the indemnifying party to such indemnified party of such indemnifying party’s election so to assume the defense of such action
and approval by the indemnified party of counsel, the indemnifying party will not be liable to such indemnified party under this Section 8 for any legal or other expenses subsequently incurred by such indemnified party in connection with the defense
thereof unless: (i) the indemnified party shall have employed separate counsel in accordance with the proviso to the next preceding sentence (it being understood, however, that the indemnifying party shall not be liable for the expenses of more than
one separate counsel (together with local counsel), approved by the indemnifying party), representing the indemnified parties who are parties to such action); (ii) the indemnifying party shall not have employed counsel satisfactory to the
indemnified party to represent the indemnified party within a reasonable time after notice of commencement of the action; or (iii) the indemnifying party has authorized the employment of counsel for the indemnified party at the expense of the
indemnifying party, in each of which cases the fees and expenses of counsel shall be at the expense of the indemnifying party. 
  

 12 

 (e)          Settlements.  The
indemnifying party under this Section 8 shall not be liable for any settlement of any proceeding effected without its written consent, which consent shall not be unreasonably withheld, but if settled with such consent or if there be a final judgment
for the plaintiff, the indemnifying party agrees to indemnify the indemnified party against any loss, claim, damage, liability or expense by reason of such settlement or judgment. No indemnifying party shall, without the prior written consent of the
indemnified party, effect any settlement, compromise or consent to the entry of judgment in any pending or threatened action, suit or proceeding in respect of which any indemnified party is or could have been a party and indemnity was or could have
been sought hereunder by such indemnified party, unless such settlement, compromise or consent includes: (i) an unconditional release of such indemnified party from all liability on claims that are the subject matter of such action, suit or
proceeding; and (ii) does not include a statement as to or an admission of fault, culpability or a failure to act by or on behalf of any indemnified party. 
  
 (f)          Contribution.  If the indemnification provided for in this Section 8 is
unavailable to or insufficient to hold harmless an indemnified party under Section 8(a) or (b) above in respect of any losses, claims, damages or liabilities (or actions or proceedings in respect thereof) then each indemnifying party shall
contribute to the aggregate amount paid or payable by such indemnified party in such proportion as is appropriate to reflect the relative benefits received by such party on the one hand and the Placement Agent on the other from the offering of the
Securities. If, however, the allocation provided by the immediately preceding sentence is not permitted by applicable law then each indemnifying party shall contribute to such amount paid or payable by such indemnified party in such proportion as is
appropriate to reflect not only such relative benefits but also the relative fault of such indemnifying party on the one hand and the Placement Agent on the other in connection with the statements or omissions which resulted in such losses, claims,
damages or liabilities (or actions or proceedings in respect thereof), as well as any other relevant equitable considerations. The relative fault shall be determined by reference to, among other things, whether the untrue or alleged untrue statement
of a material fact or the omission or alleged omission to state a material fact relates to information supplied by the Company or the “control” stockholders on the one hand or the Placement Agent on the other and the parties’ relative
intent, knowledge, access to information and opportunity to correct or prevent such statement or omission. 
  
 The Company and Placement Agent agree that it would not be just and equitable if contributions pursuant to this Section 8(f) were determined by pro rata
allocation or by any other method of allocation which does not take account of the equitable considerations referred to above in this Section 8(f). The amount paid or payable by an indemnified party as a result of the losses, claims, damages or
liabilities (or actions or proceedings in respect thereof) referred to above in this Section 8(f) shall be deemed to include any legal or other expenses reasonably incurred by such indemnified party in connection with investigating or defending any
such action or claim. Notwithstanding the provisions of this subsection (f): (i) no Placement Agent shall be required to contribute any amount in excess of the amount of the placement agent fees actually received by such Placement Agent pursuant to
this Agreement; and (ii) no person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Act) shall be entitled to contribution from any person who was not guilty of such fraudulent misrepresentation. The Placement
Agent’s obligations under this Section 8(f) to contribute are several in proportion to their respective placement obligations and not joint. 
  
 (g)          Timing of Any Payments of Indemnification.  Any losses, claims, damages,
liabilities or expenses for which an indemnified party is entitled to indemnification or contribution under this Section 8 shall be paid by the indemnifying party to the indemnified party as such losses, claims, damages, liabilities or expenses are
incurred, but in all cases, no later than forty-five (45) days of invoice to the indemnifying party. 
  

 13 

 (h)          Survival.  The indemnity
and contribution agreements contained in this Section 8 and the representations and warranties set forth in this Agreement shall remain operative and in full force and effect, regardless of: (i) any investigation made by or on behalf of any
Placement Agent or any person controlling such Placement Agent, the Company, its directors or officers or any persons controlling the Company; (ii) acceptance of any Securities and payment therefor hereunder; and (iii) any termination of this
Agreement. A successor to any Placement Agent, or to the Company, its directors or officers or any person controlling the Company, shall be entitled to the benefits of the indemnity, contribution and reimbursement agreements contained in this
Section 8. 
  
 (i)          Acknowledgements of Parties.  The parties to this Agreement hereby acknowledge that they are sophisticated business persons who were represented by counsel
during the negotiations regarding the provisions hereof including, without limitation, the provisions of this Section 8, and are fully informed regarding said provisions. They further acknowledge that the provisions of this Section 8 fairly allocate
the risks in light of the ability of the parties to investigate the Company and its business in order to assure that adequate disclosure is made in the Registration Statement and the Prospectus Supplement as required by the Act and the Exchange Act.

  
 Section 9.       [RESERVED].

  
 Section 10.     Representations and
Indemnities to Survive Delivery. 
  
 The respective
indemnities, agreements, representations, warranties and other statements of the Company or any person controlling the company, of its officers, and of the Placement Agent set forth in or made pursuant to this Agreement will remain in full force and
effect, regardless of any investigation made by or on behalf of the Placement Agent or the Company or any of its or their partners, officers or directors or any controlling person, as the case may be, and will survive delivery of and payment for the
Securities sold hereunder and any termination of this Agreement. 
  
 Section
11.     Notices. 
  
 All
communications hereunder shall be in writing and shall be mailed, hand delivered or telecopied and confirmed to the parties hereto as follows: 
  
 If to the Placement Agent: 
  
 Roth Capital Partners, LLC 
 24 Corporate Plaza 
 Newport Beach, California 92660 
 Facsimile: (949) 720-7223 
 Attention: President 
  
 With a copy to

  
 Snell & Wilmer L.L.P. 
 One Arizona Center 
 Phoenix, Arizona 85004 
 Facsimile: (602) 382-6070 
 Attention: Steven D. Pidgeon 
  

 14 

 If to the Company: 
  
 Targeted Genetics Corporation 
 1100 Olive Way, Suite 100 
 Seattle, WA 98101 
 Facsimile: (206) 233-0388 
 Attention: Chief Executive Officer 
  
 With a copy to: 
  
 Orrick, Herrington & Sutcliffe LLP 
 719 Second Avenue, Suite 900 
 Seattle, WA 98104 
 Facsimile: (206) 839-4301 
 Attention: Stephen M. Graham, Esq. 
  
 Any party hereto may change the address for receipt of communications by giving written notice to the others. 
  

	Section	 	12.   Successors. 

  
 This Agreement will inure to the benefit of and be binding upon the parties hereto, and to the benefit of the employees, officers and directors and
controlling persons referred to in Section 8, and to their respective successors, and personal representatives, and no other person will have any right or obligation hereunder. 
  

	Section	 	13.   Partial Unenforceability. 

  
 The invalidity or unenforceability of any section, paragraph or provision of this Agreement shall not affect the validity or enforceability of any other
Section, paragraph or provision hereof. If any Section, paragraph or provision of this Agreement is for any reason determined to be invalid or unenforceable, there shall be deemed to be made such minor changes (and only such minor changes) as are
necessary to make it valid and enforceable. 
  

	Section	 	14.   Governing Law Provisions. 

  
 (a)          Governing Law.  This agreement shall be governed by and construed in
accordance with the internal laws of the state of California applicable to agreements made and to be performed in such state. 
  
 (b)          Consent to Jurisdiction.  Any legal suit, action or proceeding arising out
of or based upon this Agreement or the transactions contemplated hereby (“Related Proceedings”) may be instituted in the federal courts of the United States of America located in Orange County, California, or the courts of the State of
California in each case located in Orange County (collectively, the “Specified Courts”), and each party irrevocably submits to the exclusive jurisdiction (except for proceedings instituted in regard to the enforcement of a judgment of any
such court (a “Related Judgment”), as to which such jurisdiction is non-exclusive) of such courts in any such suit, action or proceeding. Service of any process, summons, notice or document by mail to such party’s address set forth
above shall be effective service of process for any suit, action or other proceeding brought in any such court. The parties irrevocably and unconditionally waive any objection to the laying of venue of any suit, action or other proceeding in the
Specified Courts and irrevocably and unconditionally waive and agree not to plead or claim in any such court that any such suit, action or other proceeding brought in any such court has been brought in an inconvenient forum. 
  

 15 

	Section	 	15.   General Provisions. 

  
 This Agreement constitutes the entire agreement of the parties to this Agreement and supersedes all prior written or oral and all contemporaneous oral
agreements, understandings and negotiations with respect to the subject matter hereof. This Agreement may be executed in two or more counterparts, each one of which shall be an original, with the same effect as if the signatures thereto and hereto
were upon the same instrument. This Agreement may not be amended or modified unless in writing by all of the parties hereto, and no condition herein (express or implied) may be waived unless waived in writing by each party whom the condition is
meant to benefit. Section headings herein are for the convenience of the parties only and shall not affect the construction or interpretation of this Agreement. 
  

[The remainder of this page has been intentionally left blank.] 
 [Signature Page Follows] 
  

 16 

 If the foregoing is in accordance with your understanding of our agreement, please sign and return to the
Company the enclosed copies hereof, whereupon this instrument, along with all counterparts hereof, shall become a binding agreement in accordance with its terms. 
  

	 Very truly yours,

	
	 TARGETED GENETICS CORPORATION,
 a Washington corporation Company Name

		
	 By:
	 	 /s/    TODD E. SIMPSON
        

	 	 	 Name: Todd E. Simpson
 Title: V.P. Finance
& CFO

  
 The foregoing
Placement Agency Agreement is hereby confirmed and accepted by the Placement Agent as of the date first above written. 
  

	ROTH CAPITAL PARTNERS LLC
		
	 By:
	 	 /s/    BYRON C.
ROTH        

	 	 	 Name: Byron C. Roth
 Title: Chairman and
CEO

  

 17Common Stock Purchase Agreement

 EXHIBIT 10.2 
  
 EXECUTION COPY 
  
 COMMON STOCK PURCHASE AGREEMENT 
  
                 This Common Stock Purchase Agreement (this
“Agreement”) is made and effective as of June 13, 2003 by and among Targeted Genetics Corporation, a Washington corporation (the “Company”), and the Purchasers identified in the signature pages attached hereto
(each, a “Purchaser” and, collectively, the “Purchasers”). 
  
                 WHEREAS, subject to the terms and conditions set forth in this Agreement, the Company desires to sell to the Purchasers
and the Purchasers severally desire to purchase from the Company certain shares of the Company’s common stock, $0.01 par value per share (the “Common Stock”), as more fully set forth in this Agreement. 
  
                 NOW, THEREFORE, in consideration of the mutual covenants contained in this Agreement and for other good and valuable consideration the receipt
and adequacy of which are hereby acknowledged, the Company and the Purchasers agree as follows: 
  
                 1.    Closing.

  
                 (a)    The closing of the sale of the securities contemplated hereby (the “Closing”) shall take place at
the offices of Proskauer Rose LLP, 1585 Broadway, New York, New York 10036, on June 17, 2003 or on such date or location as the parties shall otherwise agree. The date of the Closing is hereinafter referred to as the “Closing Date.”
At the Closing: (x) the Company shall issue and deliver to each Purchaser (i) a stock certificate, registered in the name of such Purchaser and free of all restrictive legends, representing the number of shares of Common Stock (the shares of Common
Stock issued and sold to the Purchasers hereunder are collectively, the “Shares”) equal to the quotient obtained by dividing (a) the purchase price set forth below such Purchaser’s signature to this Agreement by (b) $2.25, or,
for Purchasers who provide the necessary account information to the Company, the Company shall cause such shares to be issued and delivered into a balance account with The Depository Trust Company through its Deposit Withdrawal Agent Commission
System, (ii) a prospectus supplement (the “Supplement”) and base prospectus (the “Prospectus”) as contained in the Registration Statement (as defined in Section 3(g)) reflecting the sale of the Securities and
(iii) the legal opinion of the Company’s outside counsel containing the opinions substantially in the form set forth in the attached Exhibit A; and (y) each Purchaser shall deliver to the Company the purchase price set forth below such
Purchaser’s signature to this Agreement, in immediately available funds by wire transfer to an account designated in writing by the Company for such purpose. 
  
                 (b)    The obligation of the Purchasers to purchase and acquire Securities under this Agreement is subject to the
fulfillment (or waiver by such Purchaser) of each of the following conditions: 

 (i)    The Company shall have filed the Supplement with the
Securities and Exchange Commission (the “Commission”). 
  
 (ii)    The Registration Statement (as defined in Section 3(g) below) shall be effective on the Closing Date as to all Securities, not subject to any threatened or actual stop order and will not on
the Closing Date contain any untrue statement of material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein not misleading. 
  
 (iii)    The Company shall have filed an additional shares listing application with the
NASDAQ Small Cap Market to cover the Securities. 
  
 (iv)    The Company shall have provided a certificate from a duly authorized officer certifying on behalf of the Company that each of the conditions set forth in this Section 1(b) shall have been satisfied. 

 
                 (c)    Notwithstanding anything to the contrary in this Section 1 and subject to Section 2 below, in the event that the
Company cannot deliver all of the items set forth in Sections 1(a) and 1(b) above, each Purchaser shall instead deliver the purchase price set forth in Section 1(a) to the Escrow Agent (the “Escrow Funds”), to be held by the Escrow
Agent in escrow on behalf of such Purchaser. Upon confirmation from all the Purchasers of receipt by the Purchasers of all the items set forth in Sections 1(a) and 1(b) above (which may be in writing or via email), the Escrow Agent shall release the
Escrow Funds to the Company. In the event all of the items set forth in Sections 1(a) and 1(b) are not delivered to a Purchaser on or prior to the Closing Date, the Escrow Agent shall immediately return the Escrow Funds to a Purchaser upon the
request of such Purchaser. The Escrow Agent hereby acknowledges and agrees to act as escrow agent in accordance with this Section 1(c). The Escrow Agent (i) shall be entitled to rely on any written or email communication received from a Purchaser
and (ii) shall not be liable for any acts or omissions of any kind any unless caused by its own gross negligence or willful misconduct. 
  
                 (d)    Definitions.    For the purposes of this Agreement, the following definitions shall apply:

  
 “Company Counsel” means Orrick, Herrington
& Sutcliffe LLP, counsel to the Company. 
  
 “Current
Reports” means (i) the Company’s Annual Report on Form 10-K for the fiscal year ended December 31, 2002, filed with the Commission on March 27, 2003, (ii) the Company’s Quarterly Report on Form 10-Q for the period ended March 31,
2003, filed with the Commission on May 15, 2003, and (iii) any reports on Form 8-K since May 15, 2003. 
  
 “Eligible Market” means any of the New York Stock Exchange, the American Stock Exchange, the NASDAQ Small Cap Market or the NASDAQ Small
Cap Market. 
  
 “Escrow Agent” means
Proskauer Rose LLP. 
  

 2 

 “Person” means any court or other federal, state, local or other governmental authority
or other individual or corporation, partnership, trust, incorporated or unincorporated association, joint venture, limited liability company, joint stock company, government (or an agency or subdivision thereof) or other entity of any kind.

  
 “Securities” means the Shares issued or
issuable pursuant to this Agreement, together with any securities issued or issuable upon any stock split, dividend or other distribution, recapitalization or similar event with respect to the foregoing. 
  
 “Transaction Documents” means this Agreement and any other
documents or agreements executed in connection with the transactions contemplated hereunder. 
  
 “Trading Day” means (a) any day on which the Common Stock is listed or quoted and traded on the NASDAQ Small-Cap Market, (b) if the Common Stock is not then listed or quoted and traded on any Eligible
Market, then a day on which trading occurs on the NASDAQ Small-Cap Market (or any successor thereto), or (c) if trading does not occur on the NASDAQ Small-Cap Market (or any successor thereto), any business day. 
  
         2.    Rights and Responsibilities of the Escrow Agent. Notwithstanding any other provision of this Agreement, in the event a dispute arises with regard
to any matter under this Agreement relating to the Escrow Funds, the following provisions shall apply. 
  
         (a)    If the Escrow Agent shall receive a written notice from a Purchaser or the
Company stating that a disagreement or dispute has arisen between the parties or any other persons resulting in adverse claims and demands being made with respect to the Escrow Funds (any such event being hereinafter referred to as a
“Dispute”), whether or not litigation has been instituted, then in any such event, the Escrow Agent shall continue to hold the Escrow Funds until the Escrow Agent receives either (i) a notice, signed by the party to such Dispute,
directing the delivery of the Escrow Funds; or (ii) a final non-appealable order of a court of competent jurisdiction, entered in an action, suit or proceeding in which the parties to the Dispute are parties, directing the delivery of the Escrow
Funds. In either of such events, the Escrow Agent shall then deliver the Escrow Funds in accordance with such direction. The Escrow Agent shall not be or become liable in any way or to any person for its refusal to comply with any such claims and
demands in the event of a Dispute unless and until it has received such direction. Upon compliance with such direction, the Escrow Agent shall be released of and from all liability and obligations hereunder. 
  
         (b)    Except for the Escrow Agent’s gross negligence or willful misconduct, the Escrow Agent shall not be responsible or liable in any manner whatsoever for the
sufficiency, correctness, genuineness or validity of any instrument deposited with it, or any notice or demand given to it or for the form of execution of any such instrument, notice or demand or for the identification, authority or rights of any
person executing, depositing or giving the same or for the terms and conditions of any instrument, pursuant to which the parties may act. 
  

 3 

         (c)    The Escrow Agent shall not
have any duties or responsibilities except those expressly set forth in Sections 1(c) and 2 of this Agreement and shall not incur any liability (i) in acting upon any signature, notice, demand, request, waiver, consent, receipt or other paper or
document believed by the Escrow Agent to be genuine and the Escrow Agent may assume that any person purporting to give it any notice on behalf of any party in accordance with the provisions hereof has been duly authorized to do so; or (ii) in
otherwise acting or failing to act under this Agreement except in the case of the Escrow Agent’s gross negligence or willful misconduct. 
  
         (d)    The terms and provisions of this Escrow arrangement shall create no right in
any person, firm or corporation other than the parties hereto and their respective successors and assigns and no third party shall have the right to enforce or benefit from the terms hereof. 
  
         (e)    The Escrow Agent shall not be bound by any modification, cancellation or rescission of this Agreement unless the same is in writing and signed by the Escrow Agent
and the other parties hereto. 
  
         (f)    The parties hereto, jointly and severally, shall indemnify the Escrow Agent from and against any and all losses, claims, damages or liabilities and expenses,
including reasonable attorney’s fees, which may be asserted against it or to which it may be exposed or may incur by reason of its performance hereunder, except to the extent caused by the Escrow Agent’s gross negligence or willful
misconduct. 
  
         (g)    The Company and the Purchasers acknowledge that the Escrow Agent has represented Mainfield Enterprises, Inc. in connection with this Agreement and may continue to
represent Mainfield Enterprises, Inc. in connection with the transactions contemplated pursuant to this Agreement, including, without limitation, in the event of disputes arising thereunder. The Company and Purchasers expressly agree that the Escrow
Agent shall not be precluded from or restricted in any manner whatsoever from representing Mainfield Enterprises, Inc. or otherwise acting as attorneys for Mainfield Enterprises, Inc. in any matter, including without limitation any court proceeding
or other matter related to this Agreement or the transactions contemplated hereby. The Company and Purchasers hereby irrevocably consent to any such representation and waive any conflict or appearance of conflict with respect thereto. 
  
         3.    Representations and Warranties of the Company. The Company hereby makes the following representations and warranties to each of the Purchasers:

  
         (a)    Subsidiaries. Except as disclosed in the Current Reports, the Company does not directly or indirectly control or own any interest in any other
corporation, partnership, joint venture or other business association or entity (a “Subsidiary”). Except as disclosed in the Current Reports, the Company owns, directly or indirectly, all of the capital stock of each Subsidiary free
and clear of any lien, charge, claim, security interest, encumbrance, right of first refusal or other restriction (collectively, “Liens”), and all the issued and outstanding shares of capital stock of each Subsidiary are validly
issued and are fully paid, non-assessable and free of preemptive and similar rights. 
  

 4 

         (b)    Organization and
Qualification. Each of the Company and the Subsidiaries is an entity duly incorporated or otherwise organized, validly existing and, as applicable, in good standing under the laws of the jurisdiction of its incorporation or organization (as
applicable), with the requisite power and authority to own and use its properties and assets and to carry on its business as currently conducted. Neither the Company nor any Subsidiary is in violation of any of the provisions of its respective
certificate or articles of incorporation, bylaws or other organizational or charter documents. Each of the Company and the Subsidiaries is duly qualified to do business and is in good standing as a foreign corporation or other entity in each
jurisdiction in which the nature of the business conducted or property owned by it makes such qualification necessary, except where the failure to be so qualified or in good standing, as the case may be, could reasonably be expected to not,
individually or in the aggregate, (i) adversely affect the legality, validity or enforceability of any Transaction Document, (ii) have or result in a material adverse effect on the results of operations, assets, business or condition (financial or
otherwise) of the Company and the Subsidiaries, taken as a whole, or (iii) adversely impair the Company’s ability to perform fully on a timely basis its obligations under any Transaction Document (any of (i), (ii) or (iii), a “Material
Adverse Effect”). 
  
         (c)    Authorization; Enforcement. The Company has the requisite corporate power and authority to enter into and to consummate the transactions contemplated
by the Transaction Documents and otherwise to carry out its obligations hereunder. The execution and delivery of each Transaction Document by the Company and the consummation by it of the transactions contemplated hereby and thereby have been duly
authorized by all necessary action on the part of the Company and no further consent or action is required by the Company, its Board of Directors or its stockholders. Each of the Transaction Documents has been (or upon delivery will be) duly
executed by the Company and, when delivered in accordance with the terms hereof, will constitute the valid and binding obligation of the Company enforceable against the Company in accordance with its terms. 
  
         (d)    No Conflicts. The execution, delivery and performance of each Transaction Document by the Company and the consummation by the Company of the
transactions contemplated hereby do not and will not (i) conflict with or violate any provision of the Company’s or any Subsidiary’s certificate or articles of incorporation, bylaws or other organizational or charter documents, or (ii)
subject to obtaining the Required Approvals (as defined below), conflict with, or constitute a default (or an event that with notice or lapse of time or both would become a default) under, or give to others any rights of termination, amendment,
acceleration or cancellation (with or without notice, lapse of time or both) of, any agreement, credit facility, debt or other instrument (evidencing a Company or Subsidiary debt or otherwise) or other understanding to which the Company or any
Subsidiary is a party or by which any property or asset of the Company or any Subsidiary is bound or affected, or (iii) result in a violation of any law, rule, regulation, order, judgment, injunction, decree or other restriction of any court or
governmental authority to which the Company or a Subsidiary is subject (including federal and state securities laws and regulations) and the rules and regulations of any self-regulatory organization to which the Company or its securities are
subject, or by which any property or asset of the Company or a Subsidiary is bound or affected; except in the case of each of clauses (ii) and (iii), such as could not, individually or in the aggregate, have or result in a Material Adverse Effect.

  

 5 

         (e)    Filings, Consents and
Approvals. Neither the Company nor any Subsidiary is required to obtain any consent, waiver, authorization or order of, give any notice to, or make any filing or registration with, any court or other federal, state, local or other
governmental authority or other Person in connection with the execution, delivery and performance by the Company of any Transaction Document, other than (i) the required filing of the Supplement, (ii) applicable Blue Sky filings, and (iii) in all
other cases where the failure to obtain such consent, waiver, authorization or order, or to give such notice or make such filing or registration could not have or result in, individually or in the aggregate, a Material Adverse Effect (collectively,
the “Required Approvals”). 
  
         (f)    Issuance of the Securities. The Securities are duly authorized and, when issued and paid for in accordance with the terms hereof, will be duly and
validly issued, fully paid and nonassessable, free and clear of all liens, encumbrances and rights of first refusal. The Company has reserved a sufficient number of duly authorized shares of Common Stock to issue all of the Securities. At the
Closing, the Securities shall have been listed for trading on the NASDAQ Small-Cap Market (the “Trading Market”). 
  
         (g)    Registration Statement. The Company’s Registration Statement
on Form S-3 (No. 333-74976) (the “Registration Statement”) was declared effective by the Commission on October 12, 2002. The Registration Statement is effective on the date hereof and the Company has not received notice that the
Commission has issued or intends to issue a stop order with respect to the Registration Statement or that the Commission otherwise has suspended or withdrawn the effectiveness of the Registration Statement, either temporarily or permanently, or
intends or has threatened in writing to do so. The Registration Statement (including the information or documents incorporated by reference therein), as of the time it was declared effective, and any amendments or supplements thereto, each as of the
time of filing, did not contain any untrue statement of material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein not misleading. The issuance of the Securities to the Purchasers is
registered by the Registration Statement. 
  
         (h)    Listing and Maintenance Requirements. Except as specified in the SEC Reports (as defined below), the Company has not, in the two years preceding the
date hereof, received notice from the Trading Market to the effect that the Company is not in compliance with the listing or maintenance requirements thereof. The Company is, and has no reason to believe that it will not in the foreseeable future
continue to be, in compliance with the listing and maintenance requirements for continued trading of the Common Stock on the Trading Market. 
  
         (i)    Certain Fees. Except for listing fees to be paid by the Company
to the Trading Market and placement agent fees payable to Roth Capital Partners, LLC, no fees or commissions will be payable by the Company to any broker, financial advisor or consultant, finder, placement agent, investment banker, bank or other
Person with respect to the transactions contemplated by the Transaction Documents. The Purchasers shall have no obligation with respect to any fees incurred by the Company or any other Person (other than the Purchasers, if the Purchasers have agreed
in writing to pay such fees) or with respect to any claims made by or on behalf of other Persons for fees of a type contemplated in this Section that may be due in connection with the transactions contemplated by the Transaction Documents. The
Company shall indemnify and hold harmless the Purchasers, their employees, officers, directors, agents, and partners, and their affiliates, from and against all claims, losses, damages, costs (including the reasonable costs of preparation and
reasonable attorney’s fees) and expenses suffered in respect of any such claimed or existing fees incurred by the Company or any other Person (other than the Purchasers, if the Purchasers have agreed in writing to pay such fees), as such fees
and expenses are incurred. 
  

 6 

         (j)    Disclosure. The
Company confirms that neither it nor any other Person acting on its behalf has provided any of the Purchasers or their agents or counsel with any information that constitutes or might constitute material, nonpublic information. The Company
understands and confirms that each of the Purchasers will rely on the foregoing representations in effecting transactions in securities of the Company. All disclosure provided to the Purchasers regarding the Company, its business and the
transactions contemplated hereby, including the Schedules to this Agreement, the Registration Statement, the Prospectus and the Supplement, furnished by or on behalf of the Company are true and correct and do not contain any untrue statement of a
material fact or omit to state any material fact necessary in order to make the statements made therein, in light of the circumstances under which they were made, not misleading. No event or circumstance has occurred or information exists with
respect to the Company or any of its Subsidiaries or its or their business, properties, prospects, operations or financial conditions, which, under applicable law, rule or regulation, requires public disclosure or announcement by the Company but
which has not been so publicly announced or disclosed (assuming for this purpose that the Company’s reports filed under the Securities Exchange Act of 1934, as amended (the “Exchange Act”) are being incorporated into an
effective registration statement filed by the Company under the Securities Act of 1933, as amended (the “Securities Act”)). The Company acknowledges and agrees that no Purchaser makes or has made any representations or warranties
with respect to the transactions contemplated hereby other than those specifically set forth in Section 3. 
  
         (k)    No Violation. The issuance and sale of the Securities hereunder
does not conflict with or violate any rules or regulations of the Trading Market. 
  
         (l)    SEC Reports; Financial Statements. The Company has filed all reports required to be filed by it under the Exchange Act,
including pursuant to Section 13(a) or 15(d) thereof, for the two years preceding the date hereof (or such shorter period as the Company was required by law to file such material) (the foregoing materials and any materials incorporated therein by
reference being collectively referred to herein as the “SEC Reports” and, together with this Agreement and the Schedules to this Agreement, the “Disclosure Materials”) on a timely basis or has received a valid
extension of such time of filing and has filed any such SEC Reports prior to the expiration of any such extension. As of their respective dates, the SEC Reports complied in all material respects with the requirements of the Securities Act and the
Exchange Act and the rules and regulations of the Commission promulgated thereunder, and none of the SEC Reports, when filed, contained any untrue statement of a material fact or omitted to state a material fact required to be stated therein or
necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading. The financial statements of the Company included in the SEC Reports comply in all material respects with applicable
accounting requirements and the rules and regulations of the Commission with respect thereto as in effect at the time of filing. Such financial statements have been prepared in accordance with generally accepted accounting principles applied on a
consistent basis during the periods involved (“GAAP”), except as may be otherwise specified in such financial statements or the notes thereto, and fairly present in all material respects the financial position of the Company and its
consolidated subsidiaries as of and for the dates thereof and the results of operations and cash flows for the periods then ended, subject, in the case of unaudited statements, to normal, immaterial, year-end audit adjustments. All material
agreements to which the Company or any Subsidiary is a party or to which the property or assets of the Company or any Subsidiary are subject are included as part of or specifically identified in the SEC Reports. 
  

 7 

         (m)    Capitalization.
The authorized capital stock of the Company consists of 120,000,000 shares of common stock, of which 50,623,439 are issued and outstanding as of June 12, 2003, and 6,000,000 shares of preferred stock, of which all outstanding shares of capital stock
are duly authorized, validly issued, fully paid and nonassessable and have been issued in compliance with all applicable securities laws. Except as disclosed in the Current Reports, there are no outstanding options, warrants, script rights to
subscribe to, calls or commitments of any character whatsoever relating to, or securities, rights or obligations convertible into or exchangeable for, or giving any Person any right to subscribe for or acquire, any shares of Common Stock, or
contracts, commitments, understandings or arrangements by which the Company or any Subsidiary is or may become bound to issue additional shares of Common Stock, or securities or rights convertible or exchangeable into shares of Common Stock. Except
as disclosed in the Current Reports, there are no anti-dilution or price adjustment provisions contained in any security issued by the Company (or in any agreement providing rights to security holders) and the issue and sale of the Securities will
not obligate the Company to issue shares of Common Stock or other securities to any Person and will not result in a right of any holder of Company securities to adjust the exercise, conversion, exchange or reset price under such securities. To the
knowledge of the Company, except as disclosed in the Current Reports, no Person or group of related Persons beneficially owns (as determined pursuant to Rule 13d-3 under the Exchange Act), or has the right to acquire, by agreement with or by
obligation binding upon the Company, beneficial ownership of in excess of 5% of the outstanding Common Stock, ignoring for such purposes any limitation on the number of shares of Common Stock that may be owned at any single time. 
  
         (n)    Material Changes. Since the date of the latest audited financial statements included within the SEC Reports, except as specifically disclosed in the
SEC Reports, (i) there has been no event, occurrence or development that, individually or in the aggregate, has had or that could result in a Material Adverse Effect, (ii) the Company has not incurred any liabilities (contingent or otherwise) other
than (A) trade payables and accrued expenses incurred in the ordinary course of business consistent with past practice and (B) liabilities not required to be reflected in the Company’s financial statements pursuant to GAAP or required to be
disclosed in filings made with the Commission, (iii) the Company has not altered its method of accounting or the identity of its auditors, except as disclosed in its SEC Reports, (iv) the Company has not declared or made any dividend or distribution
of cash or other property to its stockholders or purchased, redeemed or made any agreements to purchase or redeem any shares of its capital stock, and (v) the Company has not issued any equity securities to any officer, director or Affiliate, except
pursuant to existing Company stock-based plans. 
  
         (o)    Acknowledgment Regarding Purchasers’ Purchase of Securities. The Company acknowledges and agrees that each of the Purchasers is acting solely in
the capacity of an arm’s length purchaser with respect to this Agreement and the transactions contemplated hereby. The Company further acknowledges that no Purchaser is acting as a financial advisor or fiduciary of the Company or any other
Purchaser (or in any similar capacity) with respect to this Agreement and the transactions contemplated hereby and any advice given by any Purchaser or any of their respective representatives or agents in connection with this Agreement and the
transactions contemplated hereby is merely incidental to such Purchaser’s purchase of the Securities. The Company further represents to each Purchaser that the Company’s decision to enter into this Agreement has been based solely on the
independent evaluation of the Company and its representatives. 
  

 8 

         4.    Representations
and Warranties of the Purchasers. Each Purchaser hereby for itself and for no other Purchaser, represents, warrants and covenants to the Company that each such Purchaser is an entity is duly organized, validly existing and in good standing
under the laws of the jurisdiction of its incorporation. Such Purchaser has full right, power, authority and capacity to enter into this Agreement and to consummate the transactions contemplated hereby and has taken all necessary action to authorize
the execution, delivery and performance of this Agreement. Upon the execution and delivery of this Agreement and assuming the valid execution hereof by the Company, this Agreement shall constitute the valid and binding obligation of such Purchaser
enforceable in accordance with its terms. Such Purchaser is a resident of that jurisdiction specified next to the heading “Residence” on the signature page hereto. The Company acknowledges and agrees that no Purchaser makes or has made any
representations or warranties with respect to the transactions contemplated hereby other than those specifically set forth in this Section 4. 
  
         5.    Other Agreements of the Parties. 
  
 5.1    Lock-up 
  
         (a)    Except for the issuance of Common Stock pursuant to Section 1(b), from the date hereof through July 14, 2003 (including such date) (the “Blockout
Period”), the Company will not, directly or indirectly, offer, sell, grant any option to purchase, or otherwise dispose of (or announce any offer, sale, grant or any option to purchase or other disposition of) any of its or the
Subsidiaries’ equity or equity equivalent securities, including without limitation any debt, preferred stock or other instrument or security that is, at any time during its life and under any circumstances, convertible into or exchangeable or
exercisable for Common Stock or Common Stock Equivalents. 
  
         (b)    The restrictions contained in paragraph (a) of this Section shall not apply to (i) the granting of options to employees, officers and directors of the Company
pursuant to any stock option plan duly adopted by the Company or to the issuance of Common Stock upon exercise of such options, or (ii) transactions with entities with which the Company has pre-existing business relationships, other than financial
relationships, or such other entities whose primary business is the development, delivery and marketing of pharmaceutical products. 
  
 5.2    Disclosure of Material Non-Public Information. The Company confirms that the Company has not and shall not, and the
Company shall cause each of its Affiliates (as defined in Rule 405 under the Securities Act) and other Persons acting on its behalf not to, divulge to any Purchaser any information that it believes to be material non-public information unless such
Purchaser has agreed in writing to receive such information prior to such divulgence. Each Purchaser has made its own independent examination, investigation, analysis and evaluation of the Company, including but not limited to an evaluation of the
value of the Securities and has not relied upon any non-public information relating to the Company provided to the Purchasers by the Company or any of its Affiliates or other persons acting on its behalf. 
  

 9 

 5.3    Listing of Securities. The Company shall take such steps as may be
required to cause and maintain the listing of the Securities on the Trading Market and such other exchange, market or quotation facility on which the Common Stock is traded. 
  
 5.4    Indemnification 
  
         (a)    The Company will indemnify and hold harmless each
Purchaser and any of its affiliates or any officer, director, partner, controlling person, employee or agent of a Purchaser or any of its affiliates (a “Related Person”) for its reasonable legal and other expenses (including the
costs of any investigation, preparation and travel) and for any Losses incurred in connection with any action, claim, suit, investigation or proceeding (including, without limitation, an investigation or partial proceeding, such as a disposition),
whether commenced or threatened (each, a “Proceeding”), insofar as such Losses arise out of or are based upon any untrue statement or alleged untrue statement of any material fact contained in the Registration Statement, the
Prospectus or the Supplement, or any amendment or supplement thereto, and all other documents filed as a part thereof, as amended at the time of effectiveness of the Registration Statement, including any information deemed to be a part thereof as of
the time of effectiveness pursuant to paragraph (b) of Rule 430A, or pursuant to Rule 434, under the Securities Act, or arise out of or are based upon the omission or alleged omission to state in any of them a material fact required to be stated
therein or necessary to make the statements in any of them (in the case of the Prospectus and the Supplement only, in light of the circumstances under which they were made) not misleading, as such expenses or Losses are incurred. In addition, the
Company shall indemnify and hold harmless each Purchaser and Related Person from and against any and all Losses, as incurred, arising out of or relating to any breach by the Company of any of the representations, warranties or covenants made by the
Company in this Agreement or any other Transaction Document, or any allegation by a third party that, if true, would constitute such a breach. The conduct of any Proceeding for which indemnification is available under this paragraph shall be
governed by Section 5.4(b). The indemnification obligations of the Company under this paragraph shall be in addition to any liability that the Company may otherwise have and shall be binding upon and inure to the benefit of any successors, assigns,
heirs and personal representatives of the Purchasers and any such Related Persons. The Company also agrees that neither the Purchasers nor any Related Persons shall have any liability to the Company or any Person asserting claims on behalf of or in
right of the Company in connection with or as a result of the transactions contemplated by the Transaction Documents, except to the extent that any losses, claims, damages, liabilities or expenses incurred by the Company result from the gross
negligence or willful misconduct of the applicable Purchaser or Related Person in connection with such transactions. If the Company breaches its obligations under any Transaction Document, then, in addition to any other liabilities the Company may
have under the Transaction Documents or applicable law, the Company shall pay or reimburse the Purchasers on demand for all costs of collection and enforcement (including reasonable attorneys fees and expenses). Without limiting the generality of
the foregoing, the Company specifically agrees to reimburse the Purchasers on demand for all costs of enforcing the indemnification obligations in this paragraph. For the purposes of this Section 5.4, “Losses” shall mean any and all
losses, claims, damages, liabilities, settlement costs and expenses, including without limitation costs of preparation of legal action and reasonable attorneys’ fees. 
  

 10 

         (b)    Conduct of Indemnification
Proceedings. If any Proceeding shall be brought or asserted against any Person entitled to indemnity hereunder (an “Indemnified Party”), such Indemnified Party shall promptly notify the Person from whom indemnity is sought (the
“Indemnifying Party”) in writing, and the Indemnifying Party shall have the right to assume the defense thereof, including the employment of counsel reasonably satisfactory to the Indemnified Party and the payment of all fees and
expenses incurred in connection with defense thereof; provided, that the failure of any Indemnified Party to give such notice shall not relieve the Indemnifying Party of its obligations or liabilities pursuant to the Transaction Documents, except
(and only) to the extent that it shall be finally determined by a court of competent jurisdiction (which determination is not subject to appeal or further review) that such failure shall have proximately and materially adversely prejudiced the
Indemnifying Party. 
  
         An Indemnified Party shall have the right to employ separate counsel in any such Proceeding and to participate in the defense thereof, but the fees and expenses of such counsel shall be at the
expense of such Indemnified Party or Parties unless: (i) the Indemnifying Party has agreed in writing to pay such fees and expenses; or (ii) the Indemnifying Party shall have failed promptly to assume the defense of such Proceeding and to employ
counsel reasonably satisfactory to such Indemnified Party in any such Proceeding; or (iii) the named parties to any such Proceeding (including any impleaded parties) include both such Indemnified Party and the Indemnifying Party, and such
Indemnified Party shall have been advised by counsel that a conflict of interest is likely to exist if the same counsel were to represent such Indemnified Party and the Indemnifying Party (in which case, if such Indemnified Party notifies the
Indemnifying Party in writing that it elects to employ separate counsel at the expense of the Indemnifying Party, the Indemnifying Party shall not have the right to assume the defense thereof and such counsel shall be at the expense of the
Indemnifying Party). The Indemnifying Party shall not be liable for any settlement of any such Proceeding effected without its written consent, which consent shall not be unreasonably withheld. No Indemnifying Party shall, without the prior written
consent of the Indemnified Party, effect any settlement of any pending Proceeding in respect of which any Indemnified Party is a party, unless such settlement includes an unconditional release of such Indemnified Party from all liability on claims
that are the subject matter of such Proceeding. 
  
         All fees and expenses of the Indemnified Party (including reasonable fees and expenses to the extent incurred in connection with investigating or preparing to defend such Proceeding in a
manner not inconsistent with this Section) shall be paid to the Indemnified Party, as incurred, within ten Trading Days of written notice thereof to the Indemnifying Party (regardless of whether it is ultimately determined that an Indemnified Party
is not entitled to indemnification hereunder; provided, that the Indemnifying Party may require such Indemnified Party to undertake to reimburse all such fees and expenses to the extent it is finally judicially determined that such Indemnified Party
is not entitled to indemnification hereunder). 
  

 11 

 5.5    Registration Statement 
  
                 (a)    In addition to other remedies available to a Purchaser hereunder and under law, in the event the Registration
Statement is not effective on the date hereof and on the Closing Date, then, a Purchaser shall have the right to rescind the transactions contemplated by this Agreement. 
  
         6.    Miscellaneous  
  
         (a)    Fees and Expenses. At the Closing, the Company shall pay to Mainfield Enterprises, Inc. an aggregate of $20,000 for their legal fees and expenses incurred in
connection with its due diligence and the preparation and negotiation of this Agreement. In lieu of the foregoing payment, Mainfield Enterprises, Inc. may retain such amount at the Closing or require the Company to pay such amount directly to
Proskauer Rose LLP. Except as expressly set forth in this Agreement to the contrary, each party shall pay the fees and expenses of its advisers, counsel, accountants and other experts, if any, and all other expenses incurred by such party incident
to the negotiation, preparation, execution, delivery and performance of this Agreement. The Company shall pay all transfer agent fees, stamp taxes and other taxes and duties levied in connection with the sale and issuance of their applicable
Securities. 
  
         (b)    Securities Laws Disclosure; Publicity. The Company shall, on or before 9:30 a.m., Eastern Standard time, on June 13, 2003, issue a press release reasonably
acceptable to the Purchasers disclosing all material terms of the transactions contemplated hereby and file a Form 8-K with the Commission (the “8-K Filing”) describing the terms of the transactions contemplated by this Agreement
and including as exhibits to such 8-K Filing this Agreement, in the form required by the Exchange Act. Thereafter, the Company shall timely file any filings and notices required by the Commission or applicable law with respect to the transactions
contemplated hereby and provide copies thereof to the Purchasers promptly after filing. Neither the Company nor the Purchasers shall issue any press release or make any other public announcement relating to this Agreement unless (i) the content
thereof is mutually agreed to by the Company and the Purchasers, or (ii) such party is advised by its counsel that such press release or public announcement is required by law; except that no press release issued to disclose the issuance and sale of
the Securities to the Purchasers will refer to the Purchasers by name. Each press release disseminated during the three years preceding the date of this Agreement did not at the time of release contain any untrue statement of a material fact or omit
to state a material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they are made, not misleading. 
  
         (c)    Entire Agreement; Amendments. This
Agreement contains the entire understanding of the parties with respect to the subject matter hereof and supersedes all prior agreements and understandings, oral or written, with respect to such matters, which the parties acknowledge have been
merged into this Agreement and its exhibits and schedules. This Agreement may not be modified or amended except pursuant to an instrument in writing signed by the Company and Purchasers then holding two-thirds of the Shares purchased hereunder. The
waiver by either party hereto of any right hereunder or the failure to perform or of a breach by the other party shall not be deemed a waiver of any other right hereunder or of any other breach or failure by said other party whether of a similar
nature or otherwise. 
  

 12 

         (d)    Notices. Any and all
notices or other communications or deliveries required or permitted to be provided hereunder shall be in writing and shall be deemed given and effective on the earliest of (i) the date of transmission, if such notice or communication is delivered
via facsimile at the facsimile number specified in this Section prior to 6:30 p.m. (New York City time) on a Trading Day, (ii) the Trading Day after the date of transmission, if such notice or communication is delivered via facsimile at the
facsimile number specified in this Agreement later than 6:30 p.m. (New York City time) on any date and earlier than 11:59 p.m. (New York City time) on such date, (iii) the Trading Day following the date of mailing, if sent by nationally recognized
overnight courier service, or (iv) upon actual receipt by the party to whom such notice is required to be given. The address for such notices and communications shall be as follows: 
  

	 If to the Company:
	  	 Targeted Genetics Corporation
 1100 Olive
Way, Suite 100
 Seattle, WA 98101
 Facsimile No.: (206)
623-7064
 Attn: Chief Financial Officer

		
	 With a copy to:
	  	 Orrick, Herrington & Sutcliffe LLP
 719 Second Avenue East, Suite 900
 Seattle, WA 98104
 Facsimile No.: (206) 839-4301
 Attn: Stephen M. Graham

		
	 If to the Purchasers:
	  	To the address set forth under such Purchaser’s name on the signature pages attached hereto.

  
         or such other address as may be designated in writing hereafter, in the same manner, by such Person. 
  
         (e)    Governing Law. All questions concerning the construction, validity,
enforcement and interpretation of this Agreement shall be governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles of conflicts of law thereof. Each party agrees that all
legal proceedings concerning the interpretations, enforcement and defense of the transactions contemplated by this Agreement (whether brought against a party hereto or its respective affiliates, directors, officers, shareholders, employees or
agents) shall be commenced exclusively in the state and federal courts sitting in the City of New York, Borough of Manhattan. Each party hereto hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting in the
City of New York, Borough of Manhattan for the adjudication of any dispute hereunder or in connection herewith or with any transaction contemplated hereby or discussed herein (including with respect to the enforcement of any of this Agreement), and
hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action or proceeding is improper. Each party hereto hereby
irrevocably waives personal service 
  

 13 

 of process and consents to process being served in any such suit, action or proceeding by mailing a copy thereof via
registered or certified mail or overnight delivery (with evidence of delivery) to such party at the address in effect for notices to it under this Agreement and agrees that such service shall constitute good and sufficient service of process and
notice thereof. Nothing contained herein shall be deemed to limit in any way any right to serve process in any manner permitted by law. Each party hereto hereby irrevocably waives, to the fullest extent permitted by applicable law, any and all right
to trial by jury in any legal proceeding arising out of or relating to this Agreement or the transactions contemplated hereby. If either party shall commence an action or proceeding to enforce any provisions of this Agreement, then the prevailing
party in such action or proceeding shall be reimbursed by the other party for its reasonable attorneys fees and other reasonable costs and expenses incurred with the investigation, preparation and prosecution of such action or proceeding.

  
         (f)    Execution. This Agreement may be executed in two or more counterparts, all of which when taken together shall be considered one and the same agreement and
shall become effective when counterparts have been signed by each party and delivered to the other party, it being understood that both parties need not sign the same counterpart. In the event that any signature is delivered by facsimile
transmission, such signature shall create a valid and binding obligation of the party executing (or on whose behalf such signature is executed) the same with the same force and effect as if such facsimile signature page were an original thereof.

  
         (g)    Independent Nature of Purchasers. The obligations of each Purchaser under this Agreement are several and not joint with the obligations of any other
Purchaser, and no Purchaser shall be responsible in any way for the performance of the obligations of any other Purchaser under this Agreement. The decision of each Purchaser to purchase Securities pursuant to this Agreement has been made by such
Purchaser independently of any other Purchaser and independently of any information, materials, statements or opinions as to the business, affairs, operations, assets, properties, liabilities, results of operations, condition (financial or
otherwise) or prospects of the Company or of the Subsidiary which may have been made or given by any other Purchaser or by any agent or employee of any other Purchaser, and no Purchaser or any of its agents or employees shall have any liability to
any other Purchaser (or any other person) relating to or arising from any such information, materials, statements or opinions. Nothing contained herein, and no action taken by any Purchaser pursuant hereto, shall be deemed to constitute the
Purchasers as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that the Purchasers are in any way acting in concert or as a group with respect to such obligations or the transactions contemplated by
this Agreement. Each Purchaser shall be entitled to independently protect and enforce its rights, including without limitation the rights arising out of this Agreement, and it shall not be necessary for any other Purchaser to be joined as an
additional party in any proceeding for such purpose. 
  
     (h)    Successors and Assigns. This Agreement shall be binding upon and inure to the benefit of the parties and their successors and permitted assigns. The Company may not assign this
Agreement or any rights or obligations hereunder without the prior written consent of the Purchaser. The Purchaser may assign its rights under this Agreement to any Person. 
  

 14 

         (i)    Adjustments in Share
Numbers and Prices. In the event of any stock split, subdivision, dividend or distribution payable in shares of Common Stock (or other securities or rights convertible into, or entitling the holder thereof to receive directly or indirectly
shares of Common Stock), combination or other similar recapitalization or event occurring after the date hereof, each reference in the Transaction Documents to a number of shares or a price per share shall be amended to appropriately account for
such event. 
  
         (j)    Replacement of Securities. If any certificate or instrument evidencing any Securities is mutilated, lost, stolen or destroyed, the Company shall issue or
cause to be issued in exchange and substitution for and upon cancellation thereof, or in lieu of and substitution therefor, a new certificate or instrument, but only upon receipt of evidence reasonably satisfactory to the Company of such loss, theft
or destruction and customary and reasonable indemnity, if requested. The applicants for a new certificate or instrument under such circumstances shall also pay any reasonable third-party costs associated with the issuance of such replacement
Securities. 
  
 [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK

 SIGNATURE PAGES FOLLOW] 
  
  

 15 

 IN WITNESS WHEREOF, the parties hereto have caused this Common Stock Purchase Agreement to be duly
executed by their respective authorized signatories as of the date first indicated above. 
  

	TARGETED GENETICS CORPORATION
		
	 By:
	 	    /s/ TODD E. SIMPSON
	 	 	

	 	 	Name: Todd E. Simpson
	 	 	Title: Chief Financial Officer

  
 [REMAINDER OF
PAGE INTENTIONALLY LEFT BLANK 
 SIGNATURE PAGE OF PURCHASERS FOLLOWS] 
  
  

 16 

 IN WITNESS WHEREOF, the parties hereto have caused this Common Stock Purchase Agreement to be duly
executed by their respective authorized signatories as of the date first indicated above. 
  

	 	 	MAINFIELD ENTERPRISES, INC.
			
	 	 	 By:
	 	    /s/    AVI VIGDER
	 	 	 	 	

	 	 	 	 	 Name: Avi Vigder

	 	 	 	 	 Title: Authorized Signatory

		
	 	 	Purchase Price:
                                  $5,374,998
		
	 	 	Number of Shares to be acquired:     2,388,888
		
	 	 	 Residence:
  

	 	 	Address for Notice:
	 	 	Mainfield Enterprise, Inc.
	 	 	c/o Eldad Gal
	 	 	600 Madison Avenue
	 	 	New York, NY 10022
	 	 	Telephone No.: (212) 651-9000
	 	 	 Facsimile No.: (212) 651-9010
  

	With copies to:	 	Proskauer Rose LLP
	 	 	1585 Broadway
	 	 	New York, NY 10036-8299
	 	 	Facsimile No.: (212) 969-2900
	 	 	Attn: Adam J. Kansler, Esq.

  

	CRANSHIRE CAPITAL, L.P
		
	 By:
	 	     /s/    MITCHELL P.
KOPIN        

	 	 	Name: Mitchell P. Kopin
	 	 	Title: President-Downsview Capital
	 	 	 

	Purchase Price:	 	 $3,375,000
  

	 Number of Shares to be acquired:
	 	1,500,000
		
	 Residence:
  
	 	 
	 Address for Notice:
 Cranshire Capital,
L.P.
 666 Dundee Road, Suite 1901
 Northbrook, IL
60062
 Facsimile No.: (847) 562-9031
 Telephone No.: (847)
562-9030
 Attn: Mitchell Kopin
	 	 

  
  
  
  
  
  

 18 

  
  

	SMITHFIELD FIDUCIARY LLC
		
	 By:
	 	     /s/    ADAM J.
CHILL            

	 	 	 Name: Adam J. Chill
 Title: Authorized
Signatory

		
	 Purchase Price:
	 	 $4,375,001.25
  

	 Number of Shares to be acquired:
	 	 1,944,445
  

	 Residence: Cayman Islands
	 	 
	
	 Address for Notice:

	 Smithfield Fiduciary LLC
 c/o
Highbridge Capital Management, LLC
 9 West 57th Street, 27th Floor
 New York, New York 10019
 Facsimile No.:(212) 751-0755
 Telephone No.:(212) 287-4720
 Attn: Ari J. Storch / Adam J. Chill

  
  
  
  

 19 

	PORTSIDE GROWTH & OPPORTUNITY FUND
		
	 By:
	 	     /s/    JEFFREY M.
SOLOMON        

	 	 	Name: Jeffrey M. Solomon
	 	 	 Title: Partner
  

	Purchase Price:	 	$4,375,001.25
		
	Number of Shares to be acquired:	 	 1,944,445
  

	 Residence: Cayman Islands
  
	 	 
	 Address for Notice:
 c/o Ramius Capital
Group, L.L.C.
 666 Third Avenue, 26th Floor
 New York, NY
10017
 Facsimile: (212) 845-7999
 Telephone: (212)
845-7917
 Attn: Jeffrey M. Solomon
          Jeffrey Smith
	 	 

  

 20

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