Document:

THIS
SECURITY HAS NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE
UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”) AND
APPLICABLE STATE SECURITIES LAWS, AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT
UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE REGISTRATION REQUIREMENTS
OF THE SECURITIES ACT AND IN ACCORDANCE WITH APPLICABLE STATE SECURITIES LAWS AS EVIDENCED BY A LEGAL OPINION OF CORPORATE COUNSEL
TO THE TRANSFEROR TO SUCH EFFECT, THE SUBSTANCE OF WHICH SHALL BE REASONABLY ACCEPTABLE TO THE COMPANY.

 

	Original
    Issue Date: May 15, 2018	$300,000

 

PROMISSORY
NOTE

 

THIS
PROMISSORY NOTE is a duly authorized and validly issued Promissory Notes of Hancock Jaffe Laboratories, Inc., a Delaware corporation
(the “Company”), having its principal place of business at 70 Doppler Irvine, California, 92618 (this “Note”).

 

FOR
VALUE RECEIVED, the Company promises to pay to [] or its registered assigns (the “Holder”), or shall have paid
pursuant to the terms hereunder, the principal sum of $300,000 together with interest thereon on the earlier of (a) the IPO Date
(as defined herein), (b) August 12, 2018 and (c) any date that this Note is required to be repaid as provided hereunder (the “Maturity
Date”). This Note shall bear interest in accordance with Section 2.

 

This
Note carries an original issue discount of $50,000 (the “OID”). The Purchase Price of this Note shall be $250,000
computed by deducting the OID from the initial principal balance. The net amount to be received by the Company shall be $250,000.

 

This
Note is subject to the following additional provisions:

 

Section
1. Definitions. For the purposes hereof, in addition to the terms defined elsewhere in this Note, the following terms shall
have the following meanings:

 

“Bankruptcy
Event” means any of the following events: (a) the Company or any Significant Subsidiary (as such term is defined in
Rule 1-02(w) of Regulation S-X) thereof commences a case or other proceeding under any bankruptcy, reorganization, arrangement,
adjustment of debt, relief of debtors, dissolution, insolvency or liquidation or similar law of any jurisdiction relating to the
Company or any Significant Subsidiary thereof, (b) there is commenced against the Company or any Significant Subsidiary thereof
any such case or proceeding that is not dismissed within 60 days after commencement, (c) the Company or any Significant Subsidiary
thereof is adjudicated insolvent or bankrupt or any order of relief or other order approving any such case or proceeding is entered,
(d) the Company or any Significant Subsidiary thereof suffers any appointment of any custodian or the like for it or any substantial
part of its property that is not discharged or stayed within 60 calendar days after such appointment, (e) the Company or any Significant
Subsidiary thereof makes a general assignment for the benefit of creditors, (f) the Company or any Significant Subsidiary thereof
calls a meeting of its creditors with a view to arranging a composition, adjustment or restructuring of its debts or (g) the Company
or any Significant Subsidiary thereof, by any act or failure to act, expressly indicates its consent to, approval of or acquiescence
in any of the foregoing or takes any limited liability company or other action for the purpose of effecting any of the foregoing.

 

    	 

     

    

 

“Business
Day” means any day except any Saturday, any Sunday, any day which is a federal legal holiday in the United States or
any day on which banking institutions in the State of New York are authorized or required by law or other governmental action
to close.

 

“Event
of Default” shall have the meaning set forth in Section 6(a).

 

“IPO
Date” means the first date on which
the Buyer’s common stock is delivered by the Company to the Company’s underwriters pursuant to the provisions of an
underwriting agreement and an effective registration statement on Form S-1 (or the equivalent to such form).

 

“New
York Courts” shall have the meaning set forth in Section 7(d).

 

“Note
Register” shall have the meaning set forth in Section 2.

 

“Original
Issue Date” means the date of the first issuance of the Notes, regardless of any transfers of any Note and regardless
of the number of instruments which may be issued to evidence such Notes.

 

“Securities
Act” shall have the meaning set forth in the preamble legend to this Note.

 

Section
2. Interest; Prepayment. The Company acknowledges and agrees that this Note shall bear interest at a rate of ten percent
(10%) per annum, to be paid on the Maturity Date. All payments hereunder will be paid to the Person in whose name this Note is
registered on the records of the Company regarding registration and transfers of this Note (the “Note Register”).
At the discretion of the Company, the Principal Amount and unpaid accrued interest of this Note may be prepaid at any time.

 

Section
3. Registration of Transfers and Exchanges.

 

a)
Different Denominations. This Note is exchangeable for an equal aggregate principal amount of Notes of different authorized
denominations, as requested by the Holder surrendering the same; provided, that the minimum principal amount of any replacement
Note shall be $50,000.00. No service charge will be payable for such registration of transfer or exchange.

 

b)
Transfers. This Note may be transferred or exchanged only in compliance with applicable federal and state securities laws
and regulations to successor Holders who provide the same investment representations to the Company.

 

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c)
Reliance on Note Register. Prior to due presentment for transfer to the Company of this Note, the Company and any agent
of the Company may treat the Person in whose name this Note is duly registered on the Note Register as the owner hereof for the
purpose of receiving payment as herein provided and for all other purposes, whether or not this Note is overdue, and neither the
Company nor any such agent shall be affected by notice to the contrary.

 

Section
4. Negative Covenants.

 

As
long as at this Note remains outstanding, the Company shall not, and shall not permit any of its Subsidiaries to, directly or
indirectly:

 

a)
amend its charter documents, including, without limitation, its certificate of incorporation and bylaws, in any manner that materially
and adversely affects any rights of the Holder;

 

b)
pay cash dividends or distributions on any equity securities of the Company;

 

c)
enter into any transaction with any Affiliate of the Company which would be required to be disclosed in any public filing with
the Commission, unless such transaction is made on an arm’s-length basis and expressly approved by a majority of the disinterested
directors of the Company (even if less than a quorum otherwise required for board approval); or

 

a)
enter into any agreement with respect to any of the foregoing. 

 

Section
5. Events of Default.

 

a)
“Event of Default” means, wherever used herein, any of the following

events
(whatever the reason for such event and whether such event shall be voluntary or involuntary or effected by operation of law or
pursuant to any judgment, decree or order of any court, or any order, rule or regulation of any administrative or governmental
body):

 

i.
any default in the payment of (A) the principal amount of any Note or (B) interest, liquidated damages and other amounts
owing to a Holder on any Note, as and when the same shall become due and payable (whether on the Maturity Date or by
acceleration or otherwise) which default, solely in the case of an interest payment or other default under clause (B) above,
is not cured within fifteen (15) Business Days;

 

ii.
the Company shall fail to observe or perform any other material covenant or agreement contained in the Notes which failure is
not cured, if possible to cure, within the earlier to occur of (A) fifteen (15) Business Days after notice of such failure sent
by the Holder or by any other Holder to the Company and thirty (30) Business Days after receipt of written notice thereof;

 

iii.
any material representation or warranty made in this Note or any other Transaction Documents shall be untrue or incorrect in any
material respect as of the date when made that would cause a Material Adverse Effect; or

 

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iv.
the Company or any Significant Subsidiary (as such term is defined in Rule 1-02(w) of Regulation S-X) shall be subject to a Bankruptcy
Event.

 

b)
Remedies Upon Event of Default. If any Event of Default occurs and is continuing before the Maturity Date, the outstanding
principal amount of this Note, plus liquidated damages, interest and other amounts owing in respect thereof through the date of
acceleration, shall become, at the Holder’s election, immediately due and payable in cash. Commencing fifteen (15) Business
Days after the occurrence of any Event of Default that results in the eventual acceleration of this Note, the Principal Amount
on this Note shall increase twenty percent (20%). Upon the payment in full, the Holder shall promptly surrender this Note to or
as directed by the Company. In connection with such acceleration described herein, the Holder need not provide, and the Company
hereby waives, any presentment, demand, protest or other notice of any kind, and the Holder may immediately and without expiration
of any grace period enforce any and all of its rights and remedies hereunder and all other remedies available to it under applicable
law. Such acceleration may be rescinded and annulled by Holder at any time prior to payment hereunder and the Holder shall have
all rights as a holder of the Note until such time, if any, as the Holder receives full payment pursuant to this Section 6(b).
No such rescission or annulment shall affect any subsequent Event of Default or impair any right consequent thereon. If this Note
is placed in the hands of an attorney for collection or enforcement or is collected or enforced through any legal proceeding or
the Holder otherwise takes action to collect amounts due under this Note or to enforce the provisions of this Note the Company
shall be obligated and pay reasonable attorneys’ fees in connection with such collection, enforcement or action.

 

Section
6. Miscellaneous.

 

a)
Notices. Any and all notices or other communications or deliveries to be provided by the Holder hereunder, including, without
limitation, shall be in writing and delivered personally, by e-mail, or sent by a nationally recognized overnight courier service,
addressed to the Company, at the address set forth above, or such other e-mail address, or address as the Company may specify
for such purposes by notice to the Holder delivered in accordance with this Section 7(a). Any and all notices or other
communications or deliveries to be provided by the Company hereunder shall be in writing and delivered personally, by e-mail,
or sent by a nationally recognized overnight courier service addressed to each Holder at the e-mail address, or address of the
Holder appearing on the signature pages attached to t. Any notice or other communication or deliveries hereunder shall be deemed
given and effective on the earliest of (i) the date of transmission, if such notice or communication is delivered via e-mail at
the email address set forth on the signature pages attached to this Promissory Note prior to 5:30 p.m. (New York City time) on
any date, (ii) the next Business Day after the date of transmission, if such notice or communication is delivered via e-mail at
the e-mail address set forth on the signature pages attached to this Promissory Note on a day that is not a Business Day or later
than 5:30 p.m. (New York City time) on any Business Day, (iii) the second Business Day following the date of mailing, if sent
by U.S. nationally recognized overnight courier service or (iv) upon actual receipt by the party to whom such notice is required
to be given.

 

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b)
Absolute Obligation. Except as expressly provided herein, no provision of this Note shall alter or impair the obligation
of the Company, which is absolute and unconditional, to pay the principal of, liquidated damages and accrued interest, as applicable,
on this Note at the time, place, and rate, and in the coin or currency, herein prescribed. This Note is a direct debt obligation
of the Company.

 

c)
Lost or Mutilated Note. If this Note shall be mutilated, lost, stolen or destroyed, the Company shall execute and deliver,
in exchange and substitution for and upon cancellation of a mutilated Note, or in lieu of or in substitution for a lost, stolen
or destroyed Note, a new Note for the principal amount of this Note so mutilated, lost, stolen or destroyed, but only upon receipt
of evidence of such loss, theft or destruction of such Note, and of the ownership hereof, reasonably satisfactory to the Company.

 

d)
Governing Law. All questions concerning the construction, validity, enforcement and interpretation of this Note shall be
governed by and construed and enforced in accordance with the internal laws of the State of New York, without regard to the principles
of conflict of laws thereof. Each party agrees that all legal proceedings concerning the interpretation, enforcement and defense
of the transactions contemplated by any of the Transaction Documents (whether brought against a party hereto or its respective
Affiliates, directors, officers, shareholders, employees or agents) shall be commenced in the state and federal courts sitting
in the City of New York, Borough of Manhattan (the “New York Courts”). Each party hereto hereby irrevocably
submits to the exclusive jurisdiction of the New York Courts for the adjudication of any dispute hereunder or in connection herewith
or with any transaction contemplated hereby or discussed herein (including with respect to the enforcement of any of the Transaction
Documents), and hereby irrevocably waives, and agrees not to assert in any suit, action or proceeding, any claim that it is not
personally subject to the jurisdiction of such New York Courts, or such New York Courts are improper or inconvenient venue for
such proceeding. Each party hereby irrevocably waives personal service of process and consents to process being served in any
such suit, action or proceeding by mailing a copy thereof via registered or certified mail or overnight delivery (with evidence
of delivery) to such party at the address in effect for notices to it under this Note and agrees that such service shall constitute
good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit in any way any right
to serve process in any other manner permitted by applicable law. Each party hereto hereby irrevocably waives, to the fullest
extent permitted by applicable law, any and all right to trial by jury in any legal proceeding arising out of or relating to this
Note or the transactions contemplated hereby. If any party shall commence an action or proceeding to enforce any provisions of
this Note, then the prevailing party in such action or proceeding shall be reimbursed by the other party for its attorney’s
fees and other costs and expenses incurred in the investigation, preparation and prosecution of such action or proceeding.

 

e)
Waiver. Any waiver by the Company or the Holder of a breach of any provision of this Note shall not operate as or be construed
to be a waiver of any other breach of such provision or of any breach of any other provision of this Note. The failure of the
Company or the Holder to insist upon strict adherence to any term of this Note on one or more occasions shall not be considered
a waiver or deprive that party of the right thereafter to insist upon strict adherence to that term or any other term of this
Note on any other occasion. Any waiver by the Company or the Holder must be in writing.

 

f)
Severability. If any provision of this Note is invalid, illegal or unenforceable, the balance of this Note shall remain
in effect, and if any provision is inapplicable to any Person or circumstance, it shall nevertheless remain applicable to all
other Persons and circumstances. It is expressly understood and agreed by the parties that neither the interest, amounts payable
pursuant to Section 4, any remedy upon an Event of Default, nor any original issue discount shall be construed as interest. If
it shall be found that any interest or other amount deemed interest due hereunder violates the applicable law governing usury,
the applicable rate of interest due hereunder shall automatically be lowered to equal the maximum rate of interest permitted under
applicable law. The Company covenants (to the extent that it may lawfully do so) that it shall not at any time insist upon, plead,
or in any manner whatsoever claim or take the benefit or advantage of, any stay, extension or usury law or other law which would
prohibit or forgive the Company from paying all or any portion of the principal of or interest on this Note as contemplated herein,
wherever enacted, now or at any time hereafter in force, or which may affect the covenants or the performance of this Note, and
the Company (to the extent it may lawfully do so) hereby expressly waives all benefits or advantage of any such law, and covenants
that it will not, by resort to any such law, hinder, delay or impede the execution of any power herein granted to the Holder,
but will suffer and permit the execution of every such as though no such law has been enacted.

 

g)
Next Business Day. Whenever any payment or other obligation hereunder shall be due on a day other than a Business Day,
such payment shall be made on the next succeeding Business Day.

 

h)
Headings. The headings contained herein are for convenience only, do not constitute a part of this Note and shall not be
deemed to limit or affect any of the provisions hereof.

 

i)
Amendment. This Note may be modified or amended or the provisions hereof waived only in writing signed by both the Company
and the Holder.

 

    	5

     

    

  

IN
WITNESS WHEREOF, the Company has caused this Note to be duly executed by a duly authorized officer as of the date first above
indicated.

 

	 	HANCOCK
    JAFFE LABORATORIES, INC.
	 	 
	 	/s/
    Robert A. Berman
	 	Robert
    A. Berman
	 	Chief
    Executive Officer

 

Address
for the Company: 70 Doppler

Irvine,
California 92618

 

Address
for Holder:

289
Prospect Ave. Highland Park, IL 60035

 

    	6PROMISSORY
NOTE

 

	$[]	May
    15, 2018

 

FOR
VALUE RECEIVED, the undersigned (“Borrower”) promises to pay to [] (“Lender”),
the principal sum of _____ ($[]) in lawful money of the United States of America upon the terms and conditions specified below.

 

1.
Interest. The principal balance of this promissory note (this “Note”) outstanding from time
to time shall bear simple interest at a rate of Ten Percent (10.0%) per annum. Interest on this Note shall begin to accrue on
the date of this Note first indicated above, and shall be calculated on the basis of a Three Hundred Sixty (360) day year.

 

2.
Payment Terms. The outstanding principal amount of this Note, together with all accrued and unpaid interest thereon
and any and all other fees and charges owing hereunder, shall be due and payable upon the earlier
of (i) the closing of the underwritten initial public offering of the Borrower’s common stock, par value $0.00001 per share,
under a Registration Statement on Form S-1 under the Securities Act of 1933, as amended, or (ii) 90 days from the date of this
Note (the “Maturity Date”). All payments hereunder shall be due and payable in lawful money of
the United States of America. Unless otherwise specifically provided herein, all payments hereon shall be applied first to the
payment of any fees, costs or expenses for which Borrower is liable hereunder, next to accrued and unpaid interest and then to
reduction of principal; interest shall thereupon cease upon principal so credited.

 

3.
Prepayment. Borrower will have the right to pay, without penalty or premium, at any time, all or any portion of the
outstanding principal amount of this Note and accrued interest before the Maturity Date.

 

4.
No Oral Change. This Note may not be modified, amended, waived, extended, changed, discharged or terminated orally
or by any act or failure to act on the part of Borrower or Lender, but only by an agreement in writing signed by the party against
whom enforcement of any modification, amendment, waiver, extension, change, discharge or termination is sought.

 

5.
Default. The occurrence of any of the following shall constitute an “Event of Default”:

 

(a)
Borrower’s failure to make any payment when due under this Note or Borrower’s failure to perform, observe or comply
with any other of the terms, covenants, conditions or provisions contained in this Note and fails to cure the same within Five
(5) days after receiving written notice thereof from Lender; or

 

(b)
Borrower admits in writing Borrower’s inability to pay Borrower’s debts as such debts become due, makes a general
assignment for the benefit of creditors or files any petition or action for relief under any bankruptcy, reorganization, insolvency
or moratorium law or under any other law for the relief of, or relating to, debtors; or

 

(c)
Borrower fails to have dismissed or vacated within Forty-Five (45) calendar days following the date of filing any involuntary
petition against Borrower under any bankruptcy, reorganization, insolvency or moratorium law or under any other law for the relief
of, or relating to, debtors.

 

6.
Acceleration. Time is of the essence for every obligation under this Note. Upon the occurrence of and during the continuance
of any Event of Default, then at the option of Lender, regardless of any prior forbearance, all sums remaining unpaid under this
Note shall become immediately due and payable.

 

    	1

     

    

 

7.
Maximum Interest and Fees. Interest, fees, and charges collected under this Note shall not exceed the maximum amount
provided in any applicable law and, if any applicable maximum is exceeded, the excess collected will be refunded to Borrower or
credited as a prepayment to principal, at Lender’s option, and the amounts payable monthly hereunder shall be reduced to
a lower amount computed using the highest lawful rate allowed.

 

8.
Waiver of Notices. Borrower and all persons liable to or to become liable on this Note waive presentment, protest,
demand, notice of protest, dishonor or non-payment of this Note, and any and all other notices or matters of a like nature, consent
to any and all renewals and extensions of the time of payment hereto, and agree further that at any time and from time to time
without notice, the terms of payment hereof may be modified without in any way affecting the liability of any party to this Note,
any endorser, any guarantor, or any person liable or to become liable with respect to any indebtedness evidenced hereby.

 

9.
Security. The prompt payment and performance of the terms of this Note will be secured by a security interest in favor
of Lender in and to all of Borrower’s right, title and interest in and to the following, wherever located, whether now existing
or hereafter from time to time arising or acquired: all fixtures and personal property of every kind and nature including all
accounts (including health-care-insurance receivables), goods (including inventory and equipment), documents (including, if applicable,
electronic documents), instruments, promissory notes, chattel paper (whether tangible or electronic), letters of credit, letter-of-credit
rights (whether or not the letter of credit is evidenced by a writing), securities and all other investment property, general
intangibles (including all payment intangibles), money, deposit accounts, and any other contract rights or rights to the payment
of money; and all proceeds (such term is defined in section 9-102 of the Uniform Commercial Code as in effect from time to time
in the State of Delaware, and, in any event, shall include, without limitation, all dividends or other income from the Collateral,
collections thereon or distributions with respect thereto) and products of each of the foregoing, all books and records relating
to the foregoing, all supporting obligations related thereto, and all accessions to, substitutions and replacements for, and rents,
profits and products of, each of the foregoing, and any and all proceeds of any insurance, indemnity, warranty or guaranty payable
to the Borrower from time to time with respect to any of the foregoing.

 

10.
Reliance. The parties acknowledge and agree that this Note has been prepared at the request of the Borrower by its
outside counsel K&L Gates LLP. K&L Gates LLP does not represent any party to this Note other than the Borrower and Lender
is urged to seek its own legal and tax advice with respect to the transactions contemplated by this Note. By signing this Note,
Lender acknowledges and agrees that it has not received any legal or tax advice from K&L Gates LLP. Notwithstanding the foregoing,
this Note shall be construed without regard to any presumption or rule requiring construction or interpretation against the party
drafting this Note or causing this Note to be drafted.

 

11.
General Provisions.

 

10.1
Authority. Borrower represents it has full power, authority and legal right to execute and deliver this Note and that
this Note constitutes a valid and binding obligation of Borrower enforceable against Borrower in accordance with its terms. The
individual signing this Note on behalf of any entity represents and warrants that he or she is duly authorized to sign on behalf
of the entity and to bind the entity fully to each and all of the obligations set forth in this Note.

 

    	2

     

    

 

10.2
Construction; Interpretation. Words used in the singular shall include the plural, and vice-versa, and any gender shall
be deemed to include the other, and the words “Lender” and “Borrower” shall include their respective successors,
assigns, heirs, executors and administrators. The captions and headings contained in this Note are for convenience of reference
only, and shall not be deemed to define or limit the provisions hereof. Each party acknowledges that such party, after negotiation
has reviewed this Note. The terms of this Note shall be fairly construed and the usual rule of construction, to the effect that
any ambiguities herein should be resolved against the drafting party, shall not be employed in the interpretation of this Note
or any amendments, modifications or exhibits hereto or thereto.

 

10.3
Governing Law and Venue. The laws of the state of Delaware (without giving effect to its conflicts of laws principles)
govern all matters arising out of or relating to this Agreement and all of the transactions it contemplates, including without
limitation, its validity, interpretation, construction, performance, and enforcement.

 

10.4
No Waiver. No delay, failure or discontinuance of Lender in exercising any right, power or remedy under this Note shall
affect or operate as a waiver of such right, power or remedy; nor shall any single or partial exercise of any such right, power
or remedy preclude, waive or otherwise affect any other or further exercise thereof or the exercise of any other right, power
or remedy. Any waiver, permit, consent or approval of any kind by Lender of any breach of or default under this Note must be in
writing and shall be effective only to the extent set forth in such writing. To the extent permitted by law, Borrower waives the
right, in any action on this Note, to assert that the action was not commenced within the time required by law for the commencement
of the action. All rights of Lender stated in this Note are cumulative and in addition to all other rights provided by law, in
equity, or in any agreement executed in connection with this Note.

 

10.5
Notices. All notices and other communications under this Note must be in writing and shall be deemed to have been duly
given (a) upon delivery by hand (with written confirmation of receipt),

(b)
one day after deposit with a nationally recognized overnight delivery service (receipt requested), or (c) Five (5) days after
deposit in the United States mail by certified delivery, return receipt requested. Either party by notice to the other may designate
additional or different addresses for subsequent notices or communications. Notices shall be sent in each case to the appropriate
addresses indicated for each party on the signature page below, or such other place as the parties may from time to time designate
in writing.

 

10.6
Severability. If any provision of this Note is held invalid, illegal or unenforceable for any reason by any court of
competent jurisdiction (or, if applicable, an arbitrator), the remaining provisions of this Note shall not be affected and shall
remain in full force and effect, and this Note shall be construed as if such invalid, illegal or unenforceable provision had not
been contained in this Note. Any provision of this Note held invalid, illegal or unenforceable only in part or degree shall remain
in full force and effect to the extent not held invalid, illegal or unenforceable.

 

10.7
Successors and Assigns. This Note shall bind Borrower and its successors and assigns. This Note may not be assigned
or transferred by Lender without the prior written consent of Borrower.

 

    	3

     

    

 

IN
WITNESS WHEREOF, Borrower has duly executed this Note effective as of the day and year first above written.

 

	 	HANCOCK
    JAFFE LABORATORIES, INC.
	 	 
	 	/s/
    Robert A. Berman
	 	Robert
    A. Berman
	 	Chief
    Executive Officer

 

    	4

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