Document:

EX-10.10

 Exhibit 10.10 

CONFIDENTIAL TREATMENT REQUESTED 
 [*] = Certain
confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the
Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 
 CONFIDENTIAL 

AMENDED AND RESTATED 

DEVELOPMENT AND LICENSE AGREEMENT 

BETWEEN 
 COLUCID
PHARMACEUTICALS, INC. 
 AND 

ELI LILLY AND COMPANY 

EFFECTIVE AS OF FEBRUARY 10, 2015 

 AMENDED AND RESTATED 

DEVELOPMENT AND LICENSE AGREEMENT 

THIS AMENDED AND RESTATED DEVELOPMENT AND
LICENSE AGREEMENT (the “Agreement”), is entered into as of February 10, 2015 (the “Restatement Effective Date”), by and between
COLUCID PHARMACEUTICALS, INC. (“CoLucid”), a corporation organized and existing under the laws of the State of Delaware, having its principal place of
business at 902 North Capitol Avenue, Suite 302, Indianapolis, Indiana 46204, and ELI LILLY AND COMPANY (“Lilly”), a corporation organized and
existing under the laws of the State of Indiana, having its principal place of business at Lilly Corporate Center, Indianapolis, Indiana 46285. CoLucid and Lilly are sometimes referred to herein individually as a “Party” and
collectively as “Parties.” The Parties agree as follows: 
 BACKGROUND 

Lilly has certain intellectual property rights relating to its compound LY573144. CoLucid is interested in further developing
and commercializing LY573144. The Parties entered into a Development and License Agreement, dated December 16, 2005 (the “Original Agreement”), pursuant to which Lilly granted CoLucid a license to further develop and
commercialize, on a worldwide basis, pharmaceutical products containing LY573144. 
 The Original Agreement was
amended (or certain matters confirmed) pursuant to (i) a letter dated December 16, 2005; (ii) a letter dated March 27, 2008; (iii) a letter dated June 6, 2008; (iv) an amendment dated as of May 29, 2014; and
(v) a letter dated January 6, 2015 (collectively, the “Prior Amendments”). The Parties desire to further amend the Original Agreement and to restate the Original Agreement in its entirety as set forth in this
Agreement, after which this Agreement shall represent the complete understanding of the Parties with respect to the subject matter hereof and supersedes and replaces the Original Agreement and Prior Amendments. 

NOW, THEREFORE, in consideration of the above premises and the mutual covenants and agreements set forth
below, the Parties hereto agree as follows. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

1 

 ARTICLE 1 

DEFINITIONS 
 As used in
this Agreement, the following words and phrases shall have the following meanings: 
 “Adverse Event” means any untoward
medical occurrence in a patient or clinical investigation subject administered a medicinal product that may have, but does not necessarily have to have a causal relationship with the medicinal product, including as designated under 21 C.F.R. 312.32
and any other Applicable Laws. 
 “Affiliate” means, with respect to a Party, any Person directly or indirectly
controlling, controlled by, or under common control with, such Party. For purposes of this Agreement, the term “controlled” (including the terms “controlled by” and “under common control with”) as used in this context,
means the direct or indirect ability or power to direct or cause the direction of management policies of a Person or otherwise direct the affairs of such Person, whether through ownership of equity, voting securities, beneficial interest, by
contract or otherwise. 
 “Applicable Laws” means all applicable laws, ordinances, rules and regulations of any kind
whatsoever of any governmental (including international, foreign, federal, state and local) or regulatory authority, including, without limitation, all laws, ordinances, rules and regulations promulgated by the FDA or its counterparts in foreign
jurisdictions. 
 “Application for Marketing Authorization” means, with respect to Product, (i) in the United
States, a New Drug Application filed with the FDA pursuant to 21 U.S.C. Section 357 and 21 C.F.R. Section 314 or any successor regulatory scheme (“NDA”), and (ii) in any country other than
the United States, an application or set of applications for marketing approval comparable to an NDA and necessary to make and sell Product commercially in such country. 

“Calendar Quarter” means the three (3) month period ending on March 31, June 30, September 30
or December 31. The initial Calendar Quarter will be deemed to begin on the Original Effective Date and end on the expiration of that Calendar Quarter in which it falls. 

“Change of Control” means, with regard to a Party, any of the following events: the acquisition by any Person, other than a
Person controlling such Party as of the Original Effective Date, of “beneficial ownership” (as defined in Rule 13d-3 under the United States Securities Exchange Act of 1934, as amended), directly or indirectly, of more than fifty percent
(50%) of the shares of such Party’s stock by way of merger or sale of stock (excluding any bona fide financing transactions) or the sale or other disposition of all or substantially all of the assets of such Party to a Third Person. 

 “Clinical Trial(s)” means Phase I Clinical Trials, Phase II Clinical Trials or Phase III Clinical Trials, as
applicable. 
 “Closing Date” means the date of the closing of the Next Financing, so long as such closing date occurs
within sixty (60) days after the Original Effective Date (or such later date as the Parties may agree). 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

2 

 “CoLucid Technology” means any inventions, ideas, conceptions or reductions-to-practice, patentable or not, information, works and data that are (i) generated, identified, discovered, created or made, in whole or in part, by CoLucid, its Affiliates, its employees or a Third
Person on behalf of CoLucid, (ii) Controlled by CoLucid or its Affiliates, and (iii) necessary to manufacture, use, research, develop, sell or seek Regulatory Approval, including, without limitation, manufacturing processes, formulations,
modes of delivery and methods of use, toxicology studies, Clinical Trial information and data, and post-registration Clinical Trial information and data; in each case relating to the Compound or the Product. 

“Combination Product” means any product comprised of a combination of a Product and other product(s) or product component(s)
where: (i) the manufacture, importation, use or sale or other disposition of the other product(s) or product component(s) by itself by or on behalf of CoLucid or another Permitted Seller does not constitute an infringement of a Valid Claim;
(ii) the other product(s) or product component(s) can be sold separately by CoLucid or another Permitted Seller; and (iii) the other product(s) or product component(s) enhances the market price of the Product sold by CoLucid or another
Permitted Seller. 
 “Compound” means 2,4,6-trifluoro-N-[6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridyl]-benzamide,
which is designated as LY573144, and/or any of its pharmaceutically acceptable salts, solvates, or polymorphs. 
 “Compound
Supply” shall have the meaning set forth in Section 5.1. 
 “Confidential Information” means information
received (whether disclosed in writing, electronically, orally or by observation) by one Party (the “Receiving Party”) from the other Party (the “Disclosing Party”) that the
Disclosing Party reasonably considers proprietary and confidential unless in each case such information, as shown by competent evidence: 

(a) was known to the Receiving Party or to the public prior to the Disclosing Party’s disclosure, as demonstrated by
contemporaneous written records; 
 (b) became known to the public, after the Disclosing Party’s disclosure hereunder, other than
through a breach of the confidentiality provisions of this Agreement by the Receiving Party or any Person to whom such Receiving Party disclosed such information; 

(c) was subsequently disclosed to the Receiving Party by a Person having a legal right to disclose, without any restrictions, such
information or data; or 
 (d) was developed by the Receiving Party independent of the Disclosing Party’s Confidential
Information; 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

3 

 provided, however, that the Licensed Patents, the Lilly Know-How and any other information that pertains
to Compound or any Product disclosed to CoLucid by Lilly hereunder shall be deemed the Confidential Information of CoLucid as well as Lilly and subject to the confidentiality provisions hereof during the term of this Agreement. 

“Control” means the possession of the ability to grant a license without violating the terms of any agreement or other
arrangement with any Third Person. 
 “Damages” means any and all costs, losses, claims, demands for payment,
government enforcement actions, liabilities, fines, penalties, expenses, court costs and reasonable fees and disbursements of counsel, consultants and expert witnesses incurred by a Party hereto or its Affiliates (including any court-imposed
interest in connection therewith). 
 “Data Exclusivity Period” means the period during which the FDA (or, in
countries other than the United States, an equivalent regulatory agency) prohibits reference, without the consent of the owner of an Application for Marketing Authorization or Regulatory Approval package, to the clinical and other data that is
contained in such Application for Marketing Approval or Regulatory Approval package, and that is not published or publicly available outside of such Application for Marketing Authorization or Regulatory Approval package. 

“Development Plan” means a plan prepared by CoLucid for developing Product in the Territory, up to and including filing of
the Application for Marketing Authorization for the Product, including all Clinical Trials required to confirm the profile of Product, including but not limited to, Clinical Trials required to confirm the clinical efficacy, tolerability and dosing
regimen of Product. The initial Development Plan is attached as Exhibit C; provided, however, that CoLucid shall be entitled to amend, alter or change such Development Plan in its sole discretion, subject to its
obligations hereunder. 
 “Diligence” means use of reasonable commercial efforts, consistent with normal business
practices within the pharmaceutical industry, taking into account efficacy, the competitiveness of alternative products in the marketplace, the availability of a partner for commercialization of a Product, the degree of intellectual property
protection available for a Product, the likelihood of Regulatory Approval, the profitability of a Product, the potential impact of the prevailing conditions (such as pricing) in one market on one or more other markets, alternative products and other
relevant factors, and in any event not less than the use of efforts comparable with those used by CoLucid for similar products at a comparable stage in development and of a comparable commercial and development potential in light of such factors,
with the objective of launching a Product worldwide as soon as practicable. 
 “FDA” means the United States Food
and Drug Administration, or any successor federal agency having responsibility over Regulatory Approval. “FDA” shall also be deemed to include the applicable governmental or regulatory authority having jurisdiction over the Product in any
particular country or region in the Territory (for example, the European Medicines Evaluation Agency for the European Union). 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

4 

 “Field” means all human health uses.  

“First Commercial Sale” means the first arms-length sale of Product in a country by CoLucid or a Permitted Seller to a Third
Person following Regulatory Approval in that country. 
 “Force Majeure” shall have the meaning set forth in Section
12.3. 
 “GAAP” means U.S. Generally Accepted Accounting Principles, consistently applied. 

“Licensed Patents” means those United States and foreign patents and patent applications (including provisional applications)
listed in Exhibit A to the extent they cover making, using or selling Compound, including, without limitation: 

(a) all divisions and continuations of these applications, all patents issuing from such applications, divisions and
continuations, and any reissues, reexaminations and extensions of all such patents; and 
 (b) any
continuations-in-part, any divisions and continuations of these continuations-in-part, any patents issuing from such continuations-in-part, divisions and continuations, and any reissues, reexaminations and extensions of all such patents, in each
case to the extent that they contain one or more claims directed to the invention or inventions disclosed in the patent applications listed in Exhibit A.  

“Lilly Know-How” means any and all know-how, trade secrets, inventions, technology, information, data, ideas, specifications,
formulas or formulations, procedures, processes, plans, designs, instructions, studies, methods, or any similar items, and any related documentation, records, or materials, relating to Compound (including information relating to the previous
generation compound known as LY334370, but only to the extent relevant to development of Compound), that are owned or Controlled by Lilly as of the Original Effective Date and necessary or relevant to manufacture, use, research, develop, or sell or
seek Regulatory Approval for the Product, including any: preclinical or clinical development data or information; biological, chemical, pharmacological, toxicological, or pharmaceutical data or information; manufacturing methods, manufacturing and
quality control data or information; formulation analyses; market research specific to Product; or any similar items. Lilly Know-How does not include the Licensed Patents. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

5 

 “Major Market(s)” means Japan, France, Germany, Italy, Spain, the United
Kingdom, and the United States. 
 “NDA” has the meaning set forth under definition of “Application for
Marketing Authorization”. 
 “Net Sales” means the gross amount invoiced for sale of Products by a Permitted
Seller less the following items, consistent with GAAP:  
 (a) trade, quantity and cash discounts actually allowed;

 (b) commissions, discounts, refunds, rebates, charge backs, retroactive price adjustments, and any other allowances paid
to third parties that effectively reduce net selling price; 
 (c) actual Product returns and allowances; 

(d) any taxes or duties imposed on the production, sale, delivery or use of Products including, but not limited to, sales, use,
excise or value added taxes, other than income taxes; and 
 (e) any other expenses directly related to the sale of Products
that are allowed by GAAP, provided that such expenses are reasonable and taken in good faith. 
 For Products which are sold as Combination
Products, the Net Sales for such Combination Products shall be adjusted by multiplying the actual Net Sales by the fraction A/(A+B) where A is the invoice price of the Product, if sold separately, and B is the invoice price of the other product
or product component if sold separately. If the other product or product component is not sold separately, then the actual Net Sales shall be adjusted by multiplying the actual Net Sales by the fraction A/C where A is the invoice price of the
Product if sold separately and C is the invoice price of the Combination Product. If neither of the foregoing applies, then the Parties shall determine the Net Sales of the Combination Product in good faith. 

Net Sales amounts shall be determined from the books and records of the Permitted Seller and maintained in accordance with GAAP, consistently
applied. Further, in determining such amounts, CoLucid will use CoLucid’s then current standard procedures and methodology, including CoLucid’s then current standard exchange rate methodology for the translation of foreign currency sales
into U.S. Dollars or, in the case of other Permitted Sellers, such similar methodology, consistently applied. 
 “Next
Financing” means CoLucid’s next sale of its preferred stock after the Original Effective Date, with aggregate proceeds to CoLucid equal to or exceeding  

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

6 

 
$5,000,000 (including any proceeds attributable to the conversion of unpaid principal amounts and unpaid accrued interest on any outstanding convertible promissory notes issued by CoLucid), to
venture capital, institutional or private investors, in a single transaction, or in a series of related transactions. 
 “Original
Agreement” has the meaning set forth in the first paragraph under “BACKGROUND” above.  
 “Original
Effective Date” means December 16, 2005. 
 “Permitted Seller” means CoLucid and its Affiliates and
any permitted assignee, licensee or sublicensee having the right to sell Product hereunder.  
 “Person” means a
natural person, a corporation, a partnership, a trust, a joint venture, a limited liability company, any governmental authority, or any other entity or organization.  

“Phase I Clinical Trials” means human clinical trials conducted to establish an initial safety profile and pharmacodynamics
of Product in the particular indication tested.  
 “Phase II Clinical Trials” means human clinical trials conducted
to achieve a level of efficacy and safety of Product as well as a preliminary dosage in the particular indication tested.  

“Phase III Clinical Trials” means human clinical trials conducted to establish efficacy of Product and meet requirements to
file Applications for Marketing Authorization for Product with health regulatory authorities in the particular indication tested. 

“Prior Amendments” has the meaning set forth in the second paragraph under “BACKGROUND” above.  

“Product” means any final form human pharmaceutical composition or preparation, in any dosage strength or size, for any mode
of administration, containing Compound. Subject to the foregoing, product shall be deemed to include all expansions, improvements and modifications thereon made by or on behalf of CoLucid or an Affiliate or otherwise owned or controlled by CoLucid
or an Affiliate. 
 “Regulatory Approval” means approval of an Application for Marketing Authorization and satisfaction of
any related applicable FDA registration and notification requirements (if any).  
 “Regulatory Documents” shall
have the meaning as set forth in Section 11.3(e). 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

7 

 “Restatement Effective Date” shall have the meaning set forth in the
first paragraph hereof. 
 “Royalty Term” means, with respect to each country in which the Product is sold, on a
Product by Product basis, that time period beginning on the First Commercial Sale of Product in such country and expiring, on a country-by-country basis, on the following date: 

(a) the later of the tenth anniversary of the date of First Commercial Sale of Product in such country or the expiration in
such country of the last-to-expire Licensed Patent with a Valid Claim; or 
 (b) if there is a Data Exclusivity Period in
effect in such country for Product after the expiration of the applicable time period in (a) which provides effective market exclusivity for the Product, above, the expiration of such Data Exclusivity Period in such country. 

“Territory” means all countries of the world. 

“Third Person” means Persons other than the Parties or Affiliates thereof. 

“Valid Claim” means a claim of an issued and unexpired patent included within the Licensed Patents in a country which:
(i) but for this Agreement, would be infringed by the manufacture, importation, use or sale or other disposition of Product by or on behalf of CoLucid or another Permitted Seller, (ii) has not been revoked or held unenforceable or invalid
by a decision of a court or other governmental agency of competent jurisdiction, unappealable or unappealed within the time allowed for appeal, and (iii) has not been abandoned, disclaimed or admitted to be invalid or unenforceable through
reissue, disclaimer or otherwise. 
 ARTICLE 2 

GRANT OF LICENSE 
 2.1
License. Subject to the terms and conditions set forth herein, during the term of this Agreement, Lilly grants CoLucid an exclusive (except as to Lilly for internal research purposes as set forth in Section 2.2 below) license (with the
right to sublicense in accordance with Section 2.4) under Lilly Know-How and Licensed Patents to make, have made, use, sell, offer for sale, and import Compound and Product in the Field in the Territory, which license shall be effective as of
the Closing Date.  
 2.2 Reservation of Rights. Notwithstanding the license granted to CoLucid under Section 2.1, Lilly
reserves the right under the license to conduct research on Compound and Product for internal research purposes only. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

8 

 2.3 [Intentionally Omitted.] 

2.4 Sublicensing Rights - CoLucid Sublicenses. CoLucid may sublicense the rights granted hereunder to any of its Affiliates or any
Third Person, provided, however, that CoLucid shall notify Lilly thirty (30) days in advance of granting any sublicense and will discuss in good faith any concerns Lilly may have with such sublicense. CoLucid will remain liable for royalty
payments as a result of Net Sales made by a Permitted Seller pursuant to a sublicense and for any milestone or other payments permitted pursuant to this Section 2.4. Each sublicense granted by CoLucid under this Agreement will contain
provisions that obligate sublicensees to CoLucid to at least the same extent that CoLucid is obligated to Lilly under this Agreement. Additionally, promptly after execution, CoLucid shall provide Lilly with a copy of all sublicense agreement(s). 

 ARTICLE 3 

CONSIDERATION 
 3.1
Payments from CoLucid to Lilly.  
 (a) Issuance of Common Stock. On the
Closing Date and subject to the terms and conditions hereof, CoLucid shall issue to Lilly a number of shares (the “Initial Shares”) of CoLucid’s Common Stock (the “Common Stock”) such that
immediately after the initial closing of the Next Financing, Lilly will own 10% of the Post-Financing Shares of Common Stock (as hereinafter defined) outstanding immediately after the initial closing of the Next Financing. In the event the investors
in the Next Financing purchase additional shares of CoLucid’s preferred stock pursuant to the transaction agreements entered into for the Next Financing in any subsequent closing (each a “Subsequent Closing”), CoLucid
shall issue to Lilly such additional shares of Common Stock (the “Supplemental Shares”; together with the Initial Shares, the “Shares”) immediately after a Subsequent Closing such that Lilly will own
10% of the Post-Financing Shares of Common Stock outstanding immediately after each Subsequent Closing of the Next Financing. “Post-Financing Shares of Common Stock” means the shares of CoLucid’s Common Stock (assuming
conversion of outstanding shares of CoLucid’s preferred stock into common stock at the then applicable conversion rate): (i) issued prior to the date hereof; plus (ii) issued or issuable to Sention, Inc.
(“Sention”) in connection with the Next Financing as provided in the Asset Purchase Agreement dated as of the date hereof between CoLucid and Sention as of the applicable closing date of the Next Financing; plus
(iii) issued in the Next Financing (up to a maximum aggregate Next Financing amount of $16.5 million); plus (iv) issued or reserved for issuance pursuant to the exercise of stock options which have or may be granted under CoLucid’s
stock option plan as of the Closing Date; plus (v) issued or issuable to Lilly pursuant to this Agreement as of the applicable closing date of the Next Financing.  

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

9 

 (b) CoLucid’s Payment Upon the Closing Date. On the Closing Date,
CoLucid will pay to Lilly the non-creditable, non-refundable sum of One Million Dollars ($1,000,000.00) by Federal Reserve electronic wire transfer in immediately available funds to an account designated by Lilly.  

(c) Milestone Payments from CoLucid to Lilly. Within thirty (30) days of CoLucid or its Permitted Sellers achieving
a milestone event listed below with respect to the Product, CoLucid will notify Lilly in writing thereof and pay the below-specified non-creditable and non-refundable fees to Lilly by Federal Reserve electronic wire transfer in immediately available
funds to an account designated by Lilly. 
  

			
	Milestone Event	  	Payment
		
	Filing of First NDA in US	  	Three Million Dollars ($3,000,000)
		
	Filing of First NDA in EU in a Major Market	  	One Million Five Hundred Thousand Dollars ($1,500,000)
		
	Filing of First NDA in Japan	  	One Million Five Hundred Thousand Dollars ($1,500,000)
		
	First Regulatory Approval in US	  	Eleven Million Dollars ($11,000,000)
		
	First Regulatory Approval in EU in a Major Market	  	Two Million Five Hundred Thousand Dollars ($2,500,000)
		
	First Regulatory Approval in Japan	  	Two Million Five Hundred Thousand Dollars ($2,500,000)
		
	First fiscal year of CoLucid in which aggregate Net Sales exceed [*]	  	Ten Million Dollars ($10,000,000)
		
	Approval of each subsequent indication (may be paid more than one time for the Compound)	  	One Million Dollars ($1,000,000) per indication per market (US, EU in Major Market, Japan)

 For the avoidance of doubt, CoLucid shall not be required to pay any milestone more than one time for the
Compound, except as stated above. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

10 

 If any milestone event is achieved with respect to Compound and at such time any one or more of
the milestone events previously listed for the country in which the milestone is achieved has not been achieved with respect to Compound, then at the time of the payment of the milestone payment for such achieved milestone event, CoLucid shall pay
to Lilly the previously listed and unpaid payments for such unmet milestone events, up to and including filing of an NDA in the US or its equivalent in the EU in a Major Market or Japan. Subsequent milestone event payments will be paid within thirty
(30) days by CoLucid to Lilly as such milestone events are achieved. 
 (d) Royalty Payments from CoLucid to
Lilly. CoLucid shall pay Lilly a royalty on Net Sales of Product by Permitted Sellers during the Royalty Term as follows: 
  

					
	 Net Sales for Each Fiscal

Year of CoLucid
	  	Royalty Rate	 
	 [*]
	  	 	8	% 
	 [*]
	  	 	11	% 

 Beginning with the year in which NDA submission occurs (such year being the base year from which future
adjustments will be made), the Net Sales tiers specified above shall be adjusted each January 1 in accordance with the U.S. Bureau of Labor Statistics’ United States consumer price index for the then-just-ended calendar year. 

If in any country any person other than CoLucid or its Affiliates or sublicensees introduces any final form human pharmaceutical composition
or preparation, in any dosage, strength or size, for any mode of administration, containing a generic equivalent of Compound, as applicable, which generic equivalent has received all authorizations and approvals required by Applicable Laws for such
sale, and sales of such generic equivalent represent at least [*] of total sales in such country on a unit basis, then the royalty rate payable by CoLucid with respect to Net Sales of that Product in such country shall be reduced [*]. 

[*] 
 In the event practice or
use of a Licensed Patent consistent with the terms of this Agreement results in (i) an infringement claim by a third party or (ii) a desire on the part of CoLucid to enter into a third party license agreement based on its good faith
opinion that an infringement against such third party’s patent(s) may occur without such a license and notice to and concurrence by Lilly to such third party license (which concurrence shall not be unreasonably withheld), CoLucid shall be
entitled to credit, against royalties otherwise owed to Lilly under Section 3.1(d) above, [*] of any amount actually paid by CoLucid to such third party for a license under a patent owned or controlled by such third party; provided, however,
that CoLucid may only credit against royalties otherwise due in 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

11 

 
a calendar year such amounts that (i) are directly attributable to the manufacture or sale of Product (and not with respect to any other uses or products); and (ii) that in total for
such calendar year do not exceed [*] of Net Sales. Except as set forth in this paragraph, CoLucid shall be solely responsible for any royalties or other payments due a third party for Product. 

Lilly acknowledges that CoLucid may seek to enter into out-licensing, commercialization, and sublicensing transactions as described in
Section 2.4 or other collaboration arrangements. In the event that CoLucid seeks to enter such collaboration arrangements and determines in good faith that it is not able to do so on terms that are reasonably satisfactory to CoLucid based in
part on the amount of the royalty rates set forth in Section 3.1(d) and related terms of this Agreement, then CoLucid may give notice of such determination to Lilly. [*] 

CoLucid shall pay royalties due under this Section 3.1(d) concurrently with the remittance of the royalty report in accordance with
Section 3.2. All amounts payable to Lilly under Section 3.1 shall be paid in U.S. dollars by Federal Reserve electronic wire transfer in immediately available funds to an account designated in writing by Lilly (unless otherwise instructed
by Lilly in writing). 
 3.2 Record Retention, Royalty Reports, and Royalty Payment Schedule. CoLucid shall keep (and shall cause its
Affiliates and require its sublicensees to keep) complete and accurate books and records that are necessary to ascertain CoLucid’s compliance with this Agreement including such records as are necessary to verify royalty payments owed under
Section 3.1(d). Such records shall be kept in accordance with GAAP and CoLucid’s or its sublicensees’ internal practices and procedures, consistently applied. Beginning with the First Commercial Sale of a Product, CoLucid shall
furnish Lilly with a quarterly report on Net Sales of Product within sixty (60) days after the end of each Calendar Quarter. Such report shall include a written report detailing: (i) the Net Sales of Product for the previous Calendar
Quarter, broken down by country and between CoLucid and any Permitted Sellers, (ii) the royalty payment that is due and payable, and (iii) the basis for calculating such royalty payment. CoLucid will mail such reports to the attention of:
Eli Lilly and Company, Lilly Royalty Administration in Finance, Drop Code 1064, Lilly Corporate Center, Indianapolis, Indiana, 46285 (unless otherwise instructed by Lilly in writing). The amount of royalty payment due to Lilly shall be paid by
CoLucid concurrently with the remittance of each royalty report (that is, within sixty (60) days of the end of each Calendar Quarter). 

3.3 Milestone Payments are not Creditable. CoLucid’s milestone payments under this Article 3 are not creditable against
CoLucid’s royalty obligations to Lilly under this Article 3.  

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

12 

 3.4 Audits. Lilly will have the right, during regular business hours and
upon reasonable advance notice, to have such books and records of CoLucid described in Section 3.2 audited no more than one (1) time per calendar year so as to verify CoLucid’s compliance with the terms of this Agreement. Such audit
may cover the two (2) calendar years preceding the date of the request for such audit and may not cover any other calendar year; provided, however that Lilly may audit a given calendar year only once. Such audit right shall continue for
two (2) calendar years following termination of the Agreement. 
 Lilly will keep confidential any information obtained during
such audit. The cost of such audit will be borne by Lilly; however, if as a result of such audit the Parties agree that the amount of royalties owed to Lilly is greater than or equal to five percent (5%) or more than the amount of royalties
paid for the calendar year that is the subject of the audit, the reasonable cost of the audit will be borne by CoLucid. Within thirty (30) days after both Parties have received a copy of an audit report, CoLucid or Lilly, as appropriate, will
compensate the other Party for payment errors or omissions revealed by the audit. CoLucid will include in all sublicenses granted in accordance herewith, and any other agreements enabling a Third Person to be a Permitted Seller, an audit provision
substantially similar to the foregoing requiring such Permitted Seller to keep full and accurate books and records relating to the Product and granting Lilly the right to audit the accuracy of the information reported by the sublicensee in
connection therewith. 
 3.5 Taxes and Currency. All payments made under this Agreement shall be in United States dollars. Any and
all taxes levied on any royalty or milestone payments made by CoLucid to Lilly under this Agreement shall be the liability of and paid by Lilly. CoLucid shall be responsible for all other taxes. If laws or regulations require the withholding of such
taxes, the taxes will be deducted by CoLucid from the payment and remitted by CoLucid to the proper tax authority, provided that CoLucid will furnish Lilly with a copy of the official tax receipt on such withholdings as soon as practicable after
such withholding, and give Lilly such assistance, at Lilly’s expense, as may be reasonably necessary to enable or assist Lilly to claim exemption or take credit therefrom. Proof of payment shall be provided to Lilly within sixty (60) days
after payment. CoLucid will cooperate, at Lilly’s expense, in pursuing tax refunds, if such refund is appropriate in Lilly’s determination. 

3.6 Late Payment. Any amounts not paid by CoLucid when due under this Agreement will be subject to interest from and
including the date payment is due through and including the date upon which Lilly has collected the funds in accordance herewith at a rate equal to the lesser of (i) the sum of five percent (5%) plus the prime rate of interest quoted in
the Money Rates (or equivalent) section of the Wall Street Journal per annum, calculated daily on the basis of a three hundred sixty (360) day year, or (ii) the maximum interest rate allowed by law. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

13 

 ARTICLE 4 

INITIATION AND CONDUCT OF DEVELOPMENT 

AND COMMERCIALIZATION OF PRODUCT 

4.1 CoLucid and Lilly Representatives. Promptly (and no later than thirty (30) days) after the Closing Date, CoLucid shall
designate in writing the CoLucid representative that shall have the responsibility of communicating with Lilly personnel regarding transition support, development and commercialization of Product under this Agreement (including the provision of that
individual’s name, job title, fax and phone number). CoLucid may change such representative from time to time by written notice to Lilly containing the name and contact information for the new representative. Likewise, Lilly will promptly (and
no later than thirty (30) days) after the Closing Date, designate in writing the Lilly representative that shall have the responsibility of communicating with CoLucid under this Agreement (including the provision of that individual’s name,
job title, fax and phone number). Lilly may change such representative from time to time by written notice to CoLucid containing the name and contact information for the new representative. 

4.2 Transfer of Patent Files, Lilly Know-How and Transition Support. 

(a) Transfer of Patent Files. Lilly shall deliver, or instruct Lilly’s counsel to deliver, to CoLucid copies of the
original files of Lilly or Lilly’s counsel relating to the Licensed Patents, it being understood that Lilly promptly shall initiate the delivery process and that all such copies shall be delivered to CoLucid within thirty (30) days after
the Closing Date. Lilly also shall promptly forward, and/or instruct Lilly’s counsel to forward, to CoLucid any correspondence or other communication relating to the Licensed Patents that Lilly or any counsel employed by Lilly may receive from
any patent office in connection with the Licensed Patents. 
 (b) Provision of Lilly Know-How. Within ninety
(90) days of the Closing Date, Lilly shall use its commercially reasonable efforts to supply CoLucid with all Lilly Know-How identified on Exhibit D.  

(c) Transition Support. The Parties agree to work in good faith to complete the provision of Lilly Know-How identified
on Exhibit D to CoLucid within ninety (90) days of the Closing Date (“Transition Period”). In addition, during this time, Lilly will grant CoLucid access, during normal business hours, to appropriate
Lilly personnel for reasonable consultation related to the Lilly Know-How. Except as set forth in Section 4.2(d) below, such access to Lilly personnel during the Transition Period is at no cost to CoLucid, but shall not exceed a total of one
hundred (100) Lilly person hours. Lilly shall have no obligation to provide support of any type beyond the 100 hours mentioned above or after the Transition Period. However, if Lilly agrees to provide any additional support, CoLucid shall
promptly pay Lilly (i) an amount equal to two hundred  

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

14 

 
seventy-five dollars ($275) per hour for each such hour of services provided by Lilly, and (ii) the expenses set forth in Section 4.2(d). Lilly believes that the information listed on
Exhibit D represents all of the documents and Lilly-Know How that are in Lilly’s possession and that would be useful or relevant to CoLucid. If CoLucid has a significant need for access to any Lilly documents or Lilly Know-How not listed
on Exhibit D, it may request that Lilly provide such information, in which case Lilly will use its reasonable efforts to locate and provide such information, at CoLucid’s expense. It is understood that any such requests should be of an
infrequent and unusual nature, and that all reasonable efforts should be taken to avoid additional substantial burden on Lilly. CoLucid has advised Lilly that CoLucid may desire to retain the services of Dr. Nabih Ramadan, who has served as a
consultant to Lilly. Lilly has no objection to Dr. Ramadan providing such services, and Lilly agrees to confirm this in writing to Dr. Ramadan promptly upon the request of Dr. Ramadan or CoLucid. 

(d) Payment of Expenses. CoLucid will reimburse Lilly, within thirty (30) days of receipt of a Lilly invoice
(together with proper supporting documentation), all of the reasonable, actual travel and associated accommodation and meal expenses of Lilly personnel who travel upon CoLucid’s request in connection with the provision of transition support.
 
 4.3 CoLucid’s Obligation to Develop Compound and Product. CoLucid shall use Diligence to develop Product and obtain
Regulatory Approval in all Major Markets. CoLucid shall be responsible (financially and otherwise) for all further development (pre-clinical and clinical) for Product and Lilly shall have no obligations with respect thereto. CoLucid or its
sublicensees shall have responsibility for seeking all necessary Regulatory Approvals to develop the Product, and CoLucid or its sublicensees, shall hold legal title to all Applications for Marketing Authorizations within the Territory, and shall
assume full responsibility for the clinical protocols developed in support of such Applications for Marketing Authorization. Lilly shall have no financial obligation relating to Compound or Product. CoLucid, itself or through its sublicensees, shall
use Diligence in researching and developing the Product and otherwise carrying out its duties as contemplated under this Agreement. CoLucid will be responsible for all regulatory requirements during development and commercialization of the Compound
and Product.  
 4.4 CoLucid Obligation to Update Lilly of Product Development Progress. At least once every year, the CoLucid
representative shall provide the Lilly representative with a copy of the then current Development Plan and a summary of the activities conducted during the preceding year. In addition, at least once per year CoLucid shall provide a copy of the
detailed end of year FDA written reports describing the progress made in implementing the Development Plan. Each such report shall include with respect to the applicable one (1) year period a description of the research and development
activities conducted both in the United States and outside the United  

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

15 

 
States with respect to the Product, as well as any amendments or revisions to the Development Plan. CoLucid shall provide Lilly with regular telephonic updates on the progress made in
implementing the Development Plan and other information as Lilly may reasonably request. 
 4.5 CoLucid’s Commercialization
Obligation. 
 (a) If the Product receives Regulatory Approval in a given country, CoLucid shall use Diligence to
commercialize the Product in such country. 
 (b) CoLucid Obligation to Notify, and Lilly’s Right to Terminate for
Failure of CoLucid to Market Product. CoLucid shall promptly notify Lilly if CoLucid decides: 
 (i) not to file
for Regulatory Approval of or market Product in a Major Market; 
 (ii) to discontinue, for reasons other than Force
Majeure, the marketing of Product in a Major Market; and/or 
 (iii) not to resume the marketing of Product in a Major
Market following the expiration of a Force Majeure event. 
 Such notice or failure so to file or market, as the case may be, shall be
deemed a material breach under Section 11.2. 
 4.6 Adverse Event Reporting. CoLucid agrees to report Adverse Events that occur
during the development and marketing of Product to the relevant regulatory authorities promptly according to the Applicable Laws. CoLucid will be responsible for all safety and pharmacovigilance activities under Applicable Laws after the Closing
Date. 
 4.7 Governmental Filings. Lilly and CoLucid each agree to prepare and file whatever filings, requests or applications are
required to be filed with any governmental authority in connection with the transfer of rights in Article 2 of this Agreement and to cooperate with one another as reasonably necessary to accomplish the foregoing. 

4.8 Compliance with Law. CoLucid will comply in all material respects with all Applicable Laws relating to its development,
manufacture, distributing, marketing, promotion, selling, importing and exporting of the Product. CoLucid agrees and acknowledges that as holder of the regulatory documents with respect to Product, it will have sole responsibility for, among other
things, Adverse Event reporting and all other regulatory reporting and regulatory document maintenance obligations. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

16 

 ARTICLE 5 

SUPPLIES OF COMPOUND 

5.1 Transfer of Compound Supply. Lilly hereby assigns, transfers, and conveys to CoLucid, effective as of the Closing Date, all of
Lilly’s right, title, and interest in and to the Lilly supply of Compound and Compound intermediates, described in Exhibit B (“Compound Supply”), and within ninety (90) business days of the Closing Date, or
on such other delivery schedule reasonably acceptable to each of the Parties, Lilly will transfer to CoLucid Compound Supply as well as all existing documentation, methods and standards related to the Compound Supply. All Compound Supply is being
transferred “AS IS” without any warranty that the Compound Supply is suitable for human testing. Once possession of the Compound Supply is transferred to CoLucid, CoLucid shall be responsible for performing, or having a Third Person
perform, all quality control, quality assurance, and analytical assays (including developmental, release, related substances, stability, toxicology dosage form and end of study assays). In addition, CoLucid shall comply with any restriction on use
of Compound Supply set forth on Exhibit B. 
 5.2 Additional Supply of Compound. Except as set forth in Section 5.1,
CoLucid shall, at its own expense, provide all quantities of Compound, Compound intermediates or Product that CoLucid needs to accommodate its development and commercialization efforts under this Agreement. CoLucid acknowledges that Lilly will not
supply any quantities of Compound or Compound intermediates other than that set forth on Exhibit B. 
 ARTICLE 6 

INTELLECTUAL PROPERTY 

6.1 Intellectual Property Maintenance. Licensed Patents shall be filed, prosecuted and maintained worldwide by a Third Person patent
counsel designated by CoLucid and reasonably acceptable to Lilly. CoLucid shall have the ultimate responsibility for and control over such matters and shall bear all expenses incurred in filing, prosecuting and maintaining Licensed Patents. CoLucid
or its designee shall keep Lilly informed of the filing, prosecution and maintenance of Licensed Patents, and shall furnish to Lilly copies of substantive documents (e.g., office actions and responses) relevant to any such efforts in advance
with sufficient time for Lilly to review and provide comments on such documents, and shall in good faith take such comments into account. If CoLucid decides to allow any Licensed Patent to lapse or if CoLucid wishes to abandon any Licensed Patent,
CoLucid shall notify Lilly in writing not less than sixty (60) days prior to taking such action, and Lilly shall have the right to assume the responsibility for such Licensed Patents, and if Lilly does so, then CoLucid shall

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

17 

 
surrender to Lilly its rights under Article 2 under the patent or patent application in the country or countries so affected and Lilly may assume control of the same at Lilly’s sole expense
(it being understood that all other rights under the license to such Licensed Patent in other countries and to all other Licensed Patents under Article 2 continue). 

6.2 Enforcement of Intellectual Property Rights. CoLucid and Lilly will promptly notify the other of any infringement or
misappropriation or suspected infringement or misappropriation that may come to its notice of any intellectual property rights relating to the Product, including, without limitation, the Licensed Patents and Lilly Know-How, and will provide the
other Party with information with respect thereto. If a Third Person infringes any Licensed Patent or Lilly Know-How, CoLucid will have the first right (but not the obligation), at its own expense, to pursue any and all injunctive relief, and any or
all compensatory and other remedies and relief (collectively, “Remedies”), against such Third Person, and Lilly will have the right to participate in such action at its own expense. Should CoLucid determine not to pursue
Remedies with respect to any such infringement or misappropriation of Licensed Patents or Lilly Know-How within sixty (60) days after receipt of written notice from Lilly requesting CoLucid to do so, then Lilly will have the right (but not the
obligation), at its own expense, to pursue Remedies against such Third Person, and CoLucid shall have the right to participate in such action at its own expense. 

6.3 Assistance and Cooperation. If a Party pursues Remedies hereunder with respect to infringement or misappropriation of CoLucid
Technology, Licensed Patents or Lilly Know-How, the other Party will use all reasonable efforts to assist and cooperate with the Party pursuing such Remedies, including joining in any action or providing a power of attorney if necessary. Each Party
will bear its own costs and expenses relating to such pursuit. Any damages or other amounts collected will be distributed, first, to the Party that pursued Remedies to cover its costs and expenses; and second, to the other Party to cover its costs
and expenses, if any, relating to the pursuit of such Remedies; and any remaining amount will be distributed to the Party that pursued the Remedies, provided that any recovery by CoLucid attributable to lost sales shall be deemed Net Sales
hereunder, and a royalty paid thereon. 
 6.4 Settlement of Litigation. No settlement, consent judgment or other final disposition of
an action for infringement or validity may be entered into by a Party as to any Licensed Patent or Lilly Know-How without the other Party’s prior written consent, which consent shall not be unreasonably withheld. 

6.5 Infringement of Third Person Rights. If a Third Person institutes a patent, trade secret or other infringement suit against CoLucid
or a Permitted Seller during the term of this Agreement, alleging that the manufacture, marketing, sale, use or importation of the Product infringes one or more patent or other intellectual property rights held by such Third Person, then CoLucid
will have the sole right (but not the 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

18 

 
obligation), at its sole expense, to assume direction and control of the defense of such claims. At CoLucid’s request, Lilly will provide reasonable assistance in connection with the defense
of such claims, and CoLucid will reimburse Lilly for all documented reasonable expenses incurred by Lilly in connection therewith. CoLucid will not have the right to settle or otherwise dispose of any such claim without the consent of Lilly, which
consent will not be unreasonably withheld, unless there is no finding or admission of either infringement by or non-validity of any Licensed Patent or Lilly Know-How. 

6.6 CoLucid Technology. CoLucid will be the sole owner of the CoLucid Technology. CoLucid shall bear all expenses incurred in
preparing, filing, prosecuting and maintaining all patent applications and patents that encompass any CoLucid Technology. CoLucid or its designee shall keep Lilly reasonably informed of the filing, prosecution and maintenance of patents and patent
applications encompassing any CoLucid Technology. 
 6.7 Failure to Maintain Applications or Patents. If CoLucid decides not to
maintain or continue to prosecute any patent application or patent encompassing CoLucid Technology, it shall give Lilly reasonable written notice to this effect. After such notice, Lilly may, at its expense, maintain or continue to prosecute such
application or patent, and CoLucid shall assign such application or patent to Lilly. 
 6.8 Patent Reporting. Within sixty
(60) days after each Calendar Year, CoLucid shall provide Lilly with a written report describing the status of all Licensed Patents, including the patent country, patent and application numbers, filing date, issue date, expiration date, and any
other relevant information requested by Lilly. Such report shall be mailed to Eli Lilly and Company, Lilly Royalty Administration in Finance, Drop Code 1064, Lilly Corporate Center, Indianapolis, Indiana, 46285 (unless Lilly advises otherwise in
writing) with a copy to the General Patent Counsel. 
 6.9 Trademarks. CoLucid will own and be responsible for all trademarks related
to its marketing of Product and will be responsible, in its sole discretion, for registering, defending and maintaining such trademarks. 

6.10 Patent Cooperation. Each Party hereby agrees to make its employees, agents and consultants reasonably available to the other Party
(or the other Party’s authorized attorneys, agents or representatives) at the other Party’s expense, to the extent reasonably necessary to enable the Party responsible for prosecuting the Licensed Patents to undertake preparation, filing,
prosecution and maintenance of the Licensed Patents. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

19 

 6.11 Patent Term Extensions and Certifications. 

(a) If requested by CoLucid, Lilly shall cooperate in obtaining patent term restoration, supplementary protection
certificates or their equivalents, and patent term extensions (including but not limited to those available under the Hatch-Waxman Act) of Licensed Patents covering or claiming Products in any country and/or region where applicable. Lilly shall
provide all reasonable assistance requested by CoLucid, including permitting CoLucid to proceed with applications for such in the name of Lilly, if reasonably deemed appropriate by CoLucid, and executing documents and authorizations as required, and
providing any relevant information to CoLucid. 
 (b) CoLucid shall in its sole discretion determine which, if any,
Licensed Patent it will apply to extend. 
 (c) If requested by CoLucid, Lilly shall cooperate in maintaining with the
applicable government or regulatory authorities during the Term correct and complete listings of applicable Licensed Patents for Products being commercialized, including all “Orange Book” listings required under the Hatch-Waxman Act. 
 (d) CoLucid shall be responsible for any out-of-pocket expenses
incurred by Lilly in providing the foregoing cooperation and assistance pursuant to sub-paragraphs 6.11(a) and (c). 
 ARTICLE 7 

CONFIDENTIALITY 
 7.1
Confidential Information. The Parties agree that, unless the Receiving Party obtains the prior written consent of the Disclosing Party, at all times during the term of this Agreement and for a ten (10)-year period following its expiration or
earlier termination, the Receiving Party will keep completely confidential, will not publish or otherwise disclose and will not use directly or indirectly for any purpose other than as contemplated by this Agreement any Confidential Information of
the Disclosing Party, whether such Confidential Information was received by the Receiving Party prior to, on or after the Original Effective Date. Confidential Information exchanged under the Confidentiality and Non-Use Agreement dated
September 21, 2004 shall also be included in this Section 7.1. 
 7.2 Limited Disclosure Permitted. Each Party may disclose
Confidential Information to the extent that such disclosure is: 
 (a) required by law, in the opinion of legal
counsel to the Receiving Party; provided, however, that the Receiving Party will first have given reasonable notice to the Disclosing Party (if practicable) and given the Disclosing Party a reasonable opportunity to obtain a protective order or
confidential treatment requiring that the Confidential Information and documents that are the subject thereof be held in confidence by the recipient or, if disclosed, be used only for purposes required by such law; provided further, however, that if
a protective order is not obtained, the Confidential Information so disclosed will be limited to that information that is legally required to be disclosed as required by applicable law; 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

20 

 (b) made by the Receiving Party to a governmental or regulatory authority,
including FDA, as required to conduct Clinical Trials or obtain or maintain marketing approval for the Product, provided that reasonable effort will be taken to ensure confidential treatment of such information; 

(c) made by the Receiving Party to a Third Person as may be necessary or useful in connection with the manufacture,
development and commercialization of the Product, provided that the Receiving Party will in each case obtain from the proposed Third Person recipient a written confidentiality agreement containing confidentiality and non-use obligations no less
protective than those set forth in this Agreement; 
 (d) made by the Receiving Party to a United States or foreign
tax authority; 
 (e) made by the Receiving Party to its representatives or to Third Persons in connection with any
financing, partnering or sublicensing activities, or potential Change of Control transactions, involving the Receiving Party; provided, however, that: (i) each such representative or Third Person has a need to know such Confidential Information
and has an obligation to maintain the confidentiality of such information, (ii) the Receiving Party informs each representative or Third Person receiving Confidential Information of its confidential nature, and (iii) the Receiving Party
will be responsible for any breach of this Article 7 by any of its representatives or such Third Persons to the same extent as if the breach were by the Receiving Party; 

(f) made by a Receiving Party or any representative of the Receiving Party in the filing or publication of patents or
patent applications relating to Licensed Patents, Lilly Know-How, CoLucid Technology or any invention relating to the Compound or Product, to the extent such disclosure in the filing or publication of the patent or patent application is reasonably
necessary for support of the patent or patent application; 
 (g) made by Lilly to its attorneys, accountants,
consultants and other professionals to the extent necessary to obtain their services in connection with monitoring Lilly’s investment in CoLucid; 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

21 

 (h) made by Lilly to any Affiliate of Lilly in the ordinary course of
business, provided that Lilly remains responsible for any breach by its Affiliates of this Section 7.2.; or 

(i) made by a Receiving Party in order to comply with applicable securities law disclosure requirement or any disclosure
requirements of any applicable stock market or securities exchange. 
 7.3 Disclosure of Agreement. Except as contemplated
herein, neither Party shall disclose this Agreement (nor a redacted version thereof) to any Third Person without the prior written consent of the other Party. Without limitation, these prohibitions apply to press releases, annual reports,
prospectuses, public statements, educational and scientific conferences, promotional materials, governmental filings and discussions with public officials, securities analysts and the media. However, subject to the requirements for review and
approval that follow, this provision does not apply to a disclosure regarding this Agreement, which counsel to a Party has advised is required by Applicable Laws, to regulatory agencies such as the FDA, Securities and Exchange Commission
(“SEC”), Federal Trade Commission or Department of Justice or any applicable stock market or securities exchange. This includes requests for a copy of this Agreement or related information by tax authorities.
Notwithstanding the foregoing, Receiving Party may disclose the terms contained in this Agreement to Third Persons in connection with any activities or transactions involving the Receiving Party as set forth in Section 7.2(e). Any press release
announcing the signing of this Agreement shall be mutually approved by the Parties. 
 If any Party to this Agreement determines a
release of information regarding the existence or terms of this Agreement is required by Applicable Laws, prior to any release of such information, that Party will notify the other Party in writing as soon as practical and provide as much detail as
possible in relation to the disclosure required and, where possible under Applicable Laws, will endeavor in good faith to provide the other Party with a minimum of five (5) business days to review the proposed public statement. The Parties will
then discuss what information, if any, will actually be released and that Party shall obtain the other Party’s prior written consent or conduct any actions it may reasonably take to prevent or limit the requested disclosure. In addition, Lilly
shall have the right to review and comment on a redaction of this Agreement required by the SEC or other agencies and CoLucid shall use good faith in taking Lilly’s comments into account prior to releasing the redaction to the SEC or such
agency. 
 7.4 Survival. The confidentiality and non-use obligations of this Article 7 shall survive the termination or expiration of
this Agreement.  

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

22 

 ARTICLE 8 

REPRESENTATIONS, WARRANTIES, COVENANTS, AND DISCLAIMERS 

8.1 No Litigation, Infringement, etc. Each Party represents that, to the best of its knowledge as of the Original Effective Date, there
is no litigation or proceeding pending or threatened against or involving such Party in any court or before any agency or regulatory body which could adversely affect such Party’s ability or right to carry out the transactions contemplated by
this Agreement. Lilly represents and warrants that there is no pending litigation or proceeding which alleges that any of its activities relating to the Licensed Patents, the Lilly Know-How or the Compound have violated any of the intellectual
property rights of any other person (nor has it received any written communication threatening such litigation or proceeding). 
 8.2 No
Debarment. Each Party represents and warrants to the other that it will comply at all times with the provisions of the Generic Drug Enforcement Act of 1992 and upon request each Party will certify in writing to the other Party that neither such
Party, its employees, nor any Person providing services for such Party under this Agreement has been debarred under the provisions of such Act.  

8.3 Corporate Existence. As of the Original Effective Date, each Party represents and warrants to the other that it is a company duly
organized, validly existing, and, if relevant in its jurisdiction of formation, in good standing under the laws of the jurisdiction in which it is formed. 

8.4 Authority to Execute and Perform. As of the Original Effective Date, each Party represents and warrants to the other that it:

 (a) has the power and authority and the legal right to enter into this Agreement and perform its obligations
hereunder; 
 (b) has taken all necessary company action on its part required to authorize the execution and delivery
of this Agreement; and 
 (c) has duly executed and delivered the Agreement, which constitutes a legal, valid, and
binding obligation of it and which is enforceable against it in accordance with the Agreement’s terms. 
 8.5 Additional Lilly
Representations, Warranties and Covenants. 
 (a) Development Activities. As of the Restatement Effective Date, Lilly
represents and warrants to CoLucid that it is not presently developing or participating in the development of, and has no present plans to develop or participate in the development of, any
5-HT1F Selective Compound (as defined below). In addition, Lilly agrees that it will not undertake any human clinical testing with respect to any 5-HT1F Selective Compound for treatment or prevention of migraine or headache pain, nor grant any such rights to a Third Person, for a period of five (5) years from the Restatement Effective Date,
so long as this Agreement is in full force and effect. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

23 

 
Notwithstanding the foregoing, this provision shall not apply (i) in the event of any merger or acquisition involving Lilly and another company where such company is engaged in such research
or (ii) to any 5-HT1F Selective Compound with respect to which Lilly acquired rights via a licensing transaction or otherwise after the Restatement Effective Date. As used herein,
“5-HT1F Selective Compound” shall mean a compound that has functionally agonistic activity at the 5-HT1F receptor site and such
activity is the principal clinically desirable pharmacological activity. For the avoidance of doubt, Compound is included within the definition of 5-HT1F Selective Compound. It is understood
that, subject to Section 2.1, Lilly may (i) at any time now or in the future have or pursue development efforts for any indication with respect to compounds that principally target other 5-HT receptors and, (ii) following the five
year period referenced above, pursue development, including human testing, of 5-HT1F Selective Compounds, other than Compound, for any indication. 

(b) Patents. Lilly represents and warrants to CoLucid as of the Original Effective Date that Lilly owns the Licensed Patents.
Nothing in this Agreement shall constitute a representation or warranty by Lilly that the Licensed Patents are or will be valid or that exercise of the Licensed Patents will not infringe the intellectual property rights of others. In the event Lilly
subsequently discovers that it Controls as of the Original Effective Date any other patent rights other than the Licensed Patents that are necessary to the exercise of the Licensed Patents then Lilly will, without further consideration, amend this
Agreement to include such patent rights within the scope of the Licensed Patents. 
 (c) Purchase Entirely for Own Account.
This Agreement is made with Lilly in reliance upon Lilly’s representation to CoLucid, which by Lilly’s execution of this Agreement Lilly hereby confirms, that the Shares to be purchased by Lilly will be acquired for investment for
Lilly’s own account, not as a nominee or agent, and not with a view to the resale or distribution of any part thereof, and that Lilly has no present intention of selling, granting any participation in, or otherwise distributing the same. By
executing this Agreement, Lilly further represents that Lilly does not have any contract, undertaking, agreement or arrangement with any person to sell, transfer or grant participations to such person or to any third person, with respect to any of
the Shares. 
 (d) Reliance upon Lilly’s Representations. Lilly understands that the Shares are not registered under the
Securities Act of 1933, as amended (the “Securities Act”) on the ground that the sale provided for in this Agreement and the issuance of Shares hereunder is exempt from registration under the Securities Act, pursuant to
Section 4(2) thereof, and that CoLucid’s reliance on such exemption is predicated on Lilly’s representations set forth herein. Lilly realizes that the basis for the exemption may not be present if, notwithstanding such
representations, Lilly has in mind merely acquiring the Shares for a fixed or determinable period in the future, or for a market rise, or for sale if the market does not rise. Lilly has no such intention. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

24 

 (e) Receipt of Information. Lilly represents that Lilly has had an opportunity to
ask questions and receive answers from CoLucid regarding the terms and conditions of the offering of the Shares and the business, properties, and financial condition of CoLucid and to obtain additional information necessary to verify the accuracy of
any information furnished to Lilly or to which Lilly had access; the foregoing, however, does not limit or modify the representations and warranties of CoLucid in this Article 8 or the right of Lilly to rely thereon. 

(f) Investment Experience. Lilly represents that Lilly is experienced in evaluating and investing in private placement
transactions of securities of companies in a similar stage of development and acknowledges that Lilly is able to fend for itself, can bear the economic risk of Lilly’s investment, and has such knowledge and experience in financial and business
matters that Lilly is capable of evaluating the merits and risks of the investment in the Shares. 
 (g) Accredited Investor.
Lilly represents to CoLucid that Lilly is an “accredited investor” within the meaning of Rule 501 of Regulation D adopted pursuant to the Securities Act. 

(h) Restricted Securities. Lilly understands that the Shares may not be sold, transferred, or otherwise disposed of without
registration under the Securities Act or an exemption therefrom, and that in the absence of an effective registration statement covering the Shares or an available exemption from registration under the Securities Act, the Shares must be held
indefinitely. In particular, Lilly is aware that the Shares may not be sold pursuant to Rule 144 promulgated under the Securities Act unless all of the conditions of that Rule are met. Among the conditions for use of Rule 144 may be the
availability of current information to the public about CoLucid. Such information is not now available. 
 (i) Legends. To the
extent applicable, each certificate or other document evidencing any of the Shares shall be endorsed with the legends substantially in the form set forth below: 

(i) The following legend under the Securities Act: 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

25 

 “THE SHARES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
1933, AS AMENDED, AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED, OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER SUCH ACT, OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL OR OTHER EVIDENCE, SATISFACTORY TO THE COMPANY AND ITS
COUNSEL, THAT SUCH REGISTRATION IS NOT REQUIRED.” 
 (ii) Any legend imposed or required by the CoLucid’s Bylaws or
applicable state securities laws or any agreements referred to in Section 3.1(a). 
 (j) Between the Original Effective Date and the
Closing Date, Lilly shall use its commercially reasonable efforts to preserve and maintain the Lilly Know-How, the Licensed Patents, and the Compound, and shall not enter into any agreement or arrangement with any Third Person which conflicts or is
inconsistent with this Agreement. 
 8.6 Additional CoLucid Representations, Warranties and Covenants. 

(a) Valid Issuance of Shares. The Shares that are being purchased by Lilly hereunder, when issued, sold and delivered in
accordance with the terms of this Agreement for the consideration expressed herein, will be duly and validly issued, fully paid, and nonassessable, and will be free of restrictions on transfer other than restrictions on transfer under this Agreement
and under applicable federal and state securities laws. 
 (b) Private Offering. Subject in part to the truth and accuracy of
Lilly’s representations set forth in this Agreement, the offering, sale and issuance of the Shares as contemplated by this Agreement are exempt from the registration requirements of the Securities Act and applicable state securities laws, and
neither CoLucid nor any authorized agent acting on its behalf will take any action hereafter that would cause the loss of such exemption. 

8.7 DISCLAIMER OF IMPLIED WARRANTIES. EXCEPT AS EXPRESSLY PROVIDED IN THIS SECTION, LILLY MAKES NO REPRESENTATION OR WARRANTY AS TO THE
LICENSED PATENTS, LILLY KNOW-HOW, COMPOUND, COMPOUND SUPPLY OR PRODUCT, EXPRESS OR IMPLIED, EITHER IN FACT OR BY OPERATION OF LAW, STATUTE, OR OTHERWISE, AND LILLY SPECIFICALLY DISCLAIMS ANY AND ALL IMPLIED OR STATUTORY WARRANTIES INCLUDING
WARRANTIES OF MERCHANTABILITY, NON-INFRINGEMENT AND OF FITNESS FOR A PARTICULAR PURPOSE. FURTHER, EXCEPT AS EXPRESSLY SET FORTH IN THIS AGREEMENT, NEITHER PARTY MAKES ANY REPRESENTATION OR  

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

26 

 
WARRANTY UNDER THIS AGREEMENT, EXPRESS OR IMPLIED, EITHER IN FACT OR BY OPERATION OF LAW, STATUTE, OR OTHERWISE, AND EACH PARTY SPECIFICALLY DISCLAIMS ANY AND ALL IMPLIED OR STATUTORY WARRANTIES
INCLUDING WARRANTIES OF MERCHANTABILITY AND OF FITNESS FOR A PARTICULAR PURPOSE. Without limiting the foregoing, CoLucid acknowledges that it has not and is not relying upon any implied warranty of merchantability or of fitness for a particular
purpose or otherwise, or upon any representation or warranty whatsoever as to the prospects (financial, regulatory or otherwise), validity, or likelihood of success of Compound or Product after the Original Effective Date. 

8.8 DISCLAIMER OF INCIDENTAL AND CONSEQUENTIAL DAMAGES. NEITHER PARTY WILL BE LIABLE TO THE OTHER PARTY FOR INDIRECT, INCIDENTAL,
CONSEQUENTIAL, OR SPECIAL DAMAGES, OR FOR LOST PROFITS ARISING FROM OR RELATING TO ANY BREACH OF THIS AGREEMENT, REGARDLESS OF ANY NOTICE OF THE POSSIBILITY OF SUCH DAMAGES. NOTHING IN THIS SECTION IS INTENDED TO LIMIT OR RESTRICT THE
INDEMNIFICATION RIGHTS OR OBLIGATIONS OF ANY PARTY. 
 ARTICLE 9 

REGISTRATION AND INFORMATION RIGHTS 

9.1 Piggy-Back Registration. If CoLucid intends to register its securities in a public offering of securities solely for cash (other
than certain registrations relating to the sale of securities to employees or to a Rule 145 transaction or a registration on any form that does not include substantially the same information as would be required to be included in a registration
statement covering the sale of the Shares), CoLucid will give Lilly notice of such registration and, upon the prompt request of Lilly, CoLucid will cause to be registered all of the Shares that Lilly has requested to be included in such
registration. If the registration involves an underwriting, Lilly will enter into an underwriting agreement with the underwriter, containing customary provisions, including indemnification and, if the underwriter determines that the number of shares
in the underwritten registration must be limited, the underwriter or CoLucid may limit some or all of the Shares to be included in such registration. Lilly agrees that the registration rights described above are subordinate to the registration
rights to be granted in the Next Financing, and that CoLucid may grant at any time registration rights which are senior to, on par with, or junior to Lilly’s rights. Lilly will furnish such information as may be reasonably requested in
connection with the registration and will enter into a customary indemnification agreement with CoLucid. Further, Lilly will bear all of the fees and expenses of its counsel and all other customary “selling expenses.” The provisions in
this Section 9.1 shall survive the expiration or termination of this Agreement. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

27 

 9.2 Information Rights. CoLucid will provide to Lilly, within 180 days after the end of
each fiscal year, audited financial statements consisting of a balance sheet as of the end of such year, statements of income and of cash flows for such year and a statement of stockholders’ equity as of the end of such year. CoLucid will not
be obligated to provide information that CoLucid reasonably determines to be a trade secret or confidential. All information provided to Lilly under this Section 9.2 shall be considered Confidential Information of CoLucid. The rights and
obligations under this Section 9.2 will terminate upon the first to occur of the following: (i) CoLucid’s initial registered public offering, (ii) CoLucid becomes a reporting company under the United States Securities Exchange
Act of 1934, as amended, (iii) CoLucid is the subject of a Change of Control, or (iv) Lilly no longer holds any Shares. 

ARTICLE 10 

INDEMNIFICATION 
 10.1
Indemnification. 
 (a) CoLucid’s Obligation. Except to the extent such Damages are due to negligence, gross
negligence or willful misconduct by Lilly, its Affiliates or their officers, directors, employees or agents, CoLucid shall defend, indemnify and hold harmless Lilly and its Affiliates and their officers, directors, employees and agents against any
and all Damages incurred by any of them resulting from or arising out of: 
 (i) any material breach of any
representation or warranty made by CoLucid in this Agreement; 
 (ii) the handling, possession, development,
manufacturing, marketing, distribution, promotion, sale or use of the Product by CoLucid or a Permitted Seller;  

(iii) the exercise of any right(s) under the Licensed Patents or Lilly Know-How by CoLucid, its Affiliates, Permitted
Sellers and any permitted sublicensees; 
 (iv) CoLucid’s failure to comply in all material respects with
Applicable Laws in connection with the performance of its obligations hereunder; or 
 (v) Any other activities
conducted by CoLucid, its Affiliates, Permitted Sellers and any permitted sublicensee with respect to Compound conducted after the Closing Date. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

28 

 (b) Lilly’s Obligation. Except to the extent such Damages are due to
negligence, gross negligence or willful misconduct by CoLucid, its Affiliates or their officers, directors, employees or agents, Lilly shall defend, indemnify and hold harmless CoLucid, its Affiliates and their officers, directors, employees and
agents against any and all Damages incurred by any of them resulting from or arising out of: 
 (i) any
material breach of any representation or warranty made by Lilly in this Agreement; 
 (ii) any activities conducted by
or on behalf of Lilly with respect to rights reserved under Section 2.2; 
 (iii) the exercise of any right(s) under
the CoLucid Technology by Lilly or its Affiliates pursuant to Section 11.3(c); 
 (iv) the exercise by Lilly of
any right(s) under the Licensed Patents or Lilly Know-How prior to the Closing Date; and 
 (v) the handling,
possession, development, manufacture or use of Compound prior to the Closing Date. 
 10.2 Notice and Opportunity To Defend. 

(a) Notice. Promptly after receipt by a Party hereto of notice of any claim which could give
rise to a right to indemnification pursuant to Section 10.1, such Party (the “Indemnitee”) will give the other Party (the “Indemnifying Party”) written notice describing the claim in reasonable
detail. The failure of an Indemnitee to give notice in the manner provided herein will not relieve the Indemnifying Party of its obligations under this Article 10, except to the extent that such failure to give notice materially prejudices the
Indemnifying Party’s ability to defend such claim. 
 (b) Defense of Action. In case any action
that is subject to indemnification under this Article 10 shall be brought against an Indemnitee and it shall give written notice to the Indemnifying Party of the commencement thereof, the Indemnifying Party shall be entitled to participate and, if
it so desires, to assume the defense with counsel reasonably satisfactory to such Indemnitee. After notice from the Indemnifying Party to the Indemnitee of its election to assume the defense, the Indemnifying Party shall not be liable to such
Indemnitee under this Article 10 for any fees of other counsel or any other expenses, in each case subsequently incurred by such Indemnitee in connection with the defense. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

29 

 (c) Indemnitee’s Separate Counsel. Notwithstanding the foregoing, the
Indemnitee shall have the right to employ separate counsel and to participate in the defense of such action, and the Indemnifying Party shall bear the reasonable fees, costs and expenses of such separate counsel if: (i) the use of counsel
chosen by the Indemnifying Party to represent the Indemnitee would present such counsel with a conflict of interest, and the Indemnifying Party does not elect to engage new counsel without such a conflict; (ii) the Indemnifying Party shall not
have employed counsel reasonably satisfactory to the Indemnitee to represent the Indemnitee within a reasonable time after notice of the institution of such action; or (iii) the Indemnifying Party shall authorize the Indemnitee in writing to
employ separate counsel at the Indemnifying Party’s expense. 
 (d) Settlement. If an Indemnifying Party
assumes the defense of such action, no compromise or settlement thereof may be effected by the Indemnifying Party without the Indemnitee’s written consent, which consent shall not be unreasonably withheld or delayed, unless there is no finding
or admission of any violation of law or any violation of the rights of the Indemnitee and no effect on any other claims that may be made against the Indemnitee. In any event, the Indemnitee and the Indemnifying Party may participate, at their own
expense, in the defense of such asserted claim. 
 (e) Conduct of Defense. Notwithstanding anything to the
contrary in this Section 10.2, the Party conducting the defense of a claim will (1) keep the other Party informed on a reasonable and timely basis as to the status of the defense of such claim (but only to the extent such other Party is
not participating jointly in the defense of such claim), and (2) conduct the defense of such claim in a prudent manner. 

10.3 Survival. The provisions of this Article 10 will survive any termination or expiration of this Agreement. Each Indemnified
Party’s rights under this Article 10 will not be deemed to have been waived or otherwise affected by such Indemnified Party’s waiver of the breach of any representation, warranty, agreement or covenant contained in or made pursuant to this
Agreement, unless such waiver expressly and in writing also waives any or all of the Indemnified Party’s right under this Article 10. 

ARTICLE 11 
 TERM AND
TERMINATION 
 11.1 Term. The term of this Agreement will begin upon the Original Effective Date and, unless sooner terminated
under this Article 11, will continue in full force and effect on a country-by-country basis in the Territory until CoLucid and its Permitted Sellers have no remaining royalty payment obligations in a specific country under Section 3.1(d).
Upon expiration in a given country, CoLucid will have a fully paid  

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

30 

 
up, perpetual, irrevocable license under the Lilly Know-How in such country. If the closing of the Next Financing (and therefore the Closing Date) shall not have occurred within sixty
(60) days after the Original Effective Date, then Lilly may deliver to CoLucid a notice referring to this Section 11.1 and requesting that the closing of the Next Financing (and the Closing Date) occur; and, if such closing does not occur
within fifteen (15) business days after CoLucid’s receipt of such notice, then this Agreement shall automatically terminate. 

11.2 Material Breach by CoLucid. Upon any material breach of this Agreement by CoLucid, Lilly may, at its option, terminate this
Agreement upon ninety (90) days written notice to CoLucid. Such termination shall become effective at the end of such ninety (90) day period unless CoLucid cures such breach or violation during such ninety (90) day period; provided,
however, in the case of a breach or violation that cannot be cured within such ninety (90) day period, Lilly may terminate this Agreement following such ninety (90) day period only if CoLucid shall have failed to commence substantial
remedial actions within such ninety (90) day period and to use best efforts to pursue the same. For sake of clarity, CoLucid’s failure to Diligently develop or Diligently commercialize Product in accordance with this Agreement shall be
deemed a material breach.  
 Notwithstanding the foregoing, to the extent a material breach or material default of this Agreement by
CoLucid affects CoLucid’s performance and Lilly’s rights under this Agreement as it relates to one or more countries, but not all countries, Lilly may terminate this Agreement in accordance with this Section 11.2 as to the affected
country or countries only, and in such case this Agreement will remain in full force and effect with respect to the countries that are not terminated. Provided, however, that if such default relates to the US, Lilly may terminate this Agreement as
to all countries. 
 11.3 Rights Upon Termination by Lilly. If Lilly terminates this Agreement under Section 11.2 or 11.5, or
CoLucid terminates this Agreement under Section 11.4(a), then the following will take effect upon the effective date of such termination: 

(a) Reversion of Licensed Patents and Lilly Know-How and Direct License to Sublicensees. All rights under the Licensed
Patents and the Lilly Know-How granted by Lilly to CoLucid pursuant to Article 2 will terminate and all rights granted therein will immediately revert to Lilly with no further notice or action required on Lilly’s behalf; provided, however, that
if the termination relates only to a specific country, then only the license pertaining to such country will revert to Lilly hereunder. Any sublicensee under the rights granted to CoLucid hereunder which has not breached in any material respect its
sublicense shall be entitled to receive a license directly from Lilly granting rights substantially the same as those granted in each sublicense and containing obligations as a licensee similar to those set forth in this Agreement; provided,
however, that (i) each sublicensee shall expressly agree in writing to be bound by the terms and conditions of such direct license, and (ii) the obligations of Lilly under any such direct license shall be no greater than the obligations of
Lilly hereunder. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

31 

 (b) Reversion of Patent Maintenance Responsibilities. Upon the effective
date of the termination of this Agreement, the sole responsibility for preparing, filing, prosecuting and maintaining the Licensed Patents will revert back to Lilly with no further notice or action required on Lilly’s behalf; provided, however,
that if the termination relates only to a specific country, then only the patent maintenance obligations pertaining to such country will revert to Lilly hereunder. In such case, CoLucid will maintain its patent responsibilities for all other
Licensed Patents. 
 (c) Non-Exclusive License and Access to CoLucid Technology. CoLucid will automatically
grant to Lilly a non-exclusive, world-wide, license, with the right to sublicense, under CoLucid Technology to make, have made, use, offer to sell, sell and import Product solely in the country or countries in which CoLucid’s rights to Product
were so terminated. The Parties shall negotiate in good faith reasonable compensation from Lilly to CoLucid for such license. Lilly shall have the right, but not the obligation, at its own expense, to take legal action against Third Person
infringement of CoLucid Technology licensed under this Section 11.3(c), and CoLucid consents to be a party and cooperate with Lilly in any such action brought by Lilly pursuant to this Section 11.3(c). Lilly will reimburse CoLucid for all
documented reasonable expenses incurred by CoLucid in connection with such cooperation. Further, no settlement, consent judgment or other final disposition of an action for infringement or validity may be entered into for any CoLucid Technology
licensed under this Section 11.3(c) without Lilly’s written consent, which consent shall not be unreasonably withheld, unless there is no finding or admission of either infringement by or non-validity of any patents under such CoLucid
Technology. 
 (d) Disposition of Inventory Upon Termination. CoLucid shall promptly transfer all quantities of
any remaining Compound supplied by Lilly to CoLucid. If Lilly terminates this Agreement after CoLucid has obtained a Regulatory Approval for the Product, CoLucid will promptly offer to sell to Lilly or its designee, at CoLucid’s actual cost
(determined in accordance with GAAP) plus a reasonable markup comparable to markups charged by contract manufacturers in the pharmaceutical manufacturing industry, CoLucid’s inventory of the Product existing on the date of termination
(“CoLucid Inventory”). CoLucid will be entitled to finish manufacturing any work-in-process into the Product, and such newly made Product will be considered CoLucid Inventory hereunder. If Lilly so requests,
CoLucid shall use its commercially reasonable  

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

32 

 
efforts to continue manufacturing for Lilly for a period of time reasonably sufficient to permit Lilly to locate and qualify an alternative source of supply. If CoLucid is then utilizing third
party manufacturers, CoLucid will use its commercially reasonable efforts to cause such suppliers to provide supply to Lilly. If termination of this Agreement relates only to a specific country, the provisions of this Section 11.3(d) are
applicable only to CoLucid’s Product inventories for the country (as determined by CoLucid’s records) where such termination occurred; provided, however, that CoLucid may, at its option, promptly ship any inventory of Product in such
country to a country in which it retains the right to market and sell such Product. 
 (e) Transfer of Regulatory
Documents. CoLucid shall immediately transfer possession and ownership (and shall cause all contractors used by CoLucid to provide services hereunder to transfer possession and ownership) to Lilly (and in Lilly’s name where appropriate) of
all Clinical Trial data and information, all Clinical Trial databases, all data generated in support of Applications for Marketing Authorization, Regulatory Approvals or other regulatory commitments (e.g., toxicology and
stability data) and regulatory documents (including, but not limited to, Applications for Marketing Authorization, Regulatory Approvals and any correspondence between CoLucid and any sublicensee or contractor of CoLucid and any regulatory agency)
that were created and/or developed under the terms of this Agreement for Compound or Product (collectively, the “Regulatory Documents”); provided, however, that if the termination relates only to a specific
country, then only the Regulatory Documents pertaining to such country will be transferred to Lilly hereunder. In such case, CoLucid will maintain possession and ownership of all other Regulatory Documents. Should Lilly elect to sublicense, or to
co-market or co-promote Product with a Third Person in the Territory, pursuant to Lilly’s rights under this Section 11.3, Lilly shall have the right to provide appropriate access to such Clinical
Trial data or information, Clinical Trial databases, all data generated in support of any Application for Marketing Authorization, Regulatory Approval other regulatory commitment, or Regulatory Document to such Third Person. Except as contemplated
by subsection (c) above, CoLucid shall not be entitled to any compensation for the use of Regulatory Materials. 

(f) Assignment of Trademarks. CoLucid shall assign to Lilly its trademark rights for the Product, including, without
limitation, any back-up marks, registrations, or applications for such marks and the goodwill associated with such marks; provided, however, that if the termination relates only to a specific country, then only the trademark rights pertaining to
such country will be transferred to Lilly hereunder. In such case, CoLucid will maintain possession and ownership of all other trademarks. The parties shall negotiate in good faith reasonable compensation from Lilly to CoLucid for such trademark and
goodwill. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

33 

 11.4 Termination by CoLucid. 

(a) If CoLucid reasonably believes, in light of the factors identified in the definition of Diligence in Article 1, that
it would be commercially unreasonable to continue to develop the Product as set forth in this Agreement, it may terminate this Agreement upon ninety (90) days written notice to Lilly. 

(b) Upon any material breach of this Agreement by Lilly, CoLucid may, at its option, terminate this Agreement upon
ninety (90) days written notice to Lilly. Such termination shall become effective at the end of such ninety (90) day period unless Lilly cures such breach or violation during such ninety (90) day period; provided, however, in the case
of a breach or violation that cannot be cured within such ninety (90) day period, CoLucid may terminate this Agreement following such ninety (90) day period only if Lilly shall have failed to commence substantial remedial actions within
such ninety (90) day period and to use best efforts to pursue the same. 
 (c) If CoLucid terminates this
Agreement under Section 11.4(a), then the terms of Section 11.3 shall apply. If CoLucid terminates this Agreement under Section 11.4(b), 11.5, or 12.3, then CoLucid shall retain any and all licenses granted to it by Lilly pursuant to
Section 2.1 (unless otherwise terminated pursuant to the terms of this Agreement), and CoLucid’s payment obligations under Article 3 and other relevant provisions shall continue in full force and effect, but CoLucid’s Diligence
obligations under Sections 4.3, 4.4 and 4.5(a) will terminate. 
 11.5 Termination for Bankruptcy. Notwithstanding any other
provision of this Article 11, either Party may terminate this Agreement by providing written notice to the other Party (with immediate effect) if the other Party: 

(a) makes a general assignment of substantially all of its assets for the benefit of creditors; 

(b) petitions for or acquiesces in the appointment of any receiver, trustee or similar officer to liquidate or conserve
its business or all or substantially all of its assets; or 
 (c) voluntarily commences under the laws of any
jurisdiction any proceeding for relief under the Bankruptcy Code of 1986, as amended (“Code”) or similar bankruptcy laws in applicable jurisdictions, involving its insolvency, reorganization, adjustment of debt, dissolution,
liquidation or any other similar proceeding for the release of financially distressed debtors. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

34 

 11.6 Change in CoLucid’s Ownership. If CoLucid undergoes a Change of Control, CoLucid
will promptly notify Lilly in writing thereof and Lilly may terminate this Agreement by providing written notice to CoLucid and such termination shall become effective upon CoLucid’s receipt of such notice unless the new controlling Third
Person agrees in writing to be bound by the terms and conditions of this Agreement and to undertake all of CoLucid’s obligations under this Agreement. 

11.7 Residual Obligation Upon Termination. Termination of this Agreement for any reason will not relieve either Party of any obligation
or liability accruing prior thereto and will be without prejudice to the rights and remedies of either Party with respect to any antecedent breach of the provisions of this Agreement. Without limiting the generality of the foregoing and in addition
to the foregoing and the rights upon termination set forth in Sections 11.2 and 11.4, no termination of this Agreement, whether by lapse of time or otherwise, will serve to terminate the rights and obligations of the Parties hereto with respect
to this Agreement as it relates to the jurisdiction(s) for which this Agreement has not been terminated. The provisions of Article 1, Section 6.6, Article 7, Sections 8.7 and 8.8, Article 9, Article 10, Section 11.3, 11.7, 11.8, 11.9 and
Article 12 are intended to and shall survive termination or expiration of this Agreement in accordance with the terms of such Articles or Sections. 

11.8 Additional Remedies. The remedies set forth in this Article 11 or elsewhere in this Agreement will be in addition to, and will not
be to the exclusion of, any other remedies available to the Parties at law, in equity or under this Agreement. 
 11.9 Further
Assurances. CoLucid covenants and agrees that if this Agreement is terminated under Sections 11.2, 11.5 or 12.3, and if any Regulatory Document(s) described in Section 11.3(d) or any trademark described in Section 11.3(e) cannot
be transferred or assigned under Applicable Law, or is untransferable by its nature, then CoLucid will cause the beneficial interest in and to the same, in any event, to pass to Lilly, and CoLucid, covenants and agrees, after such termination to
hold such Regulatory Document(s) and trademark(s) in trust for, and for the benefit of Lilly; provided, all payments owed to CoLucid under this Agreement have been paid by Lilly. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

35 

 ARTICLE 12 

MISCELLANEOUS 
 12.1
Independent Contractor. It is understood and agreed that the Parties shall have the status of an independent contractor under this Agreement and that nothing in this Agreement shall be construed as creating any partnership, joint venture or
employer-employee relationship between the Parties or as authorization for either CoLucid or Lilly to act as agent for the other. 
 12.2
No Benefit to Others. The representations, warranties, covenants and agreements contained in this Agreement are for the sole benefit of the Parties and their legal representatives, successors and assigns, and they shall not be construed as
conferring any rights to any Third Person. 
 12.3 Force Majeure. If either Party is affected by any extraordinary, unexpected and
unavoidable event such as acts of God, floods, fires, riots, war, labor disturbances, failures of sources of supply, infectious diseases of animals, or by the reason of any law, order, proclamation, regulation, ordinance, demand or requirement of
the relevant government or any authority or representative thereof, or by reason of any other cause whatsoever (provided that in all such cases the Party claiming relief on account of such event can demonstrate that such event was extraordinary,
unexpected and unavoidable by the exercise of reasonable care) (“Force Majeure”) it shall notify the other Party within five (5) business days of the nature and extent thereof and take all reasonable steps to overcome
the Force Majeure and to minimize the loss occasioned to that other Party. Such notice will be provided within five (5) business days of the occurrence of such event and will identify the requirements of this Agreement or such of its
obligations as may be affected, and, subject to the provisions below, to the extent so affected, said obligations will be suspended during the period of such disability. The Party prevented from performing hereunder will use reasonable efforts to
remove such disability and will continue performance whenever such causes are removed. The Party so affected will give to the other Party a good faith estimate of the continuing effect of the Force Majeure condition and the duration of the affected
Party’s nonperformance. 
 If the period of any previous actual nonperformance of Lilly because of Lilly Force Majeure conditions plus
the anticipated future period of Lilly nonperformance because of such conditions will exceed an aggregate of one hundred eighty (180) consecutive days within any one year period, CoLucid may terminate this Agreement immediately by written
notice to Lilly. 
 If the period of any previous actual nonperformance of CoLucid because of CoLucid Force Majeure conditions will exceed
one hundred eighty (180) consecutive days, Lilly may terminate this Agreement immediately by written notice to CoLucid; provided, however, that to the extent such nonperformance by CoLucid affects CoLucid’s

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
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36 

 
performance and Lilly’s rights under this Agreement as it relates to one or more countries, but not all countries, Lilly may terminate this Agreement after such one hundred eighty
(180) day period as to the affected country or countries only, and in such case this Agreement will remain in full force and effect with respect to the countries that are not terminated. 

Notwithstanding the foregoing, when such circumstances as those contemplated herein arise, the Parties will discuss in good faith, what, if
any, modification of the terms set forth herein may be required in order to arrive at an equitable solution. 
 12.4 Amendment. This
Agreement may not be amended, supplemented, or otherwise modified except by an instrument in writing signed by authorized representatives of the Parties. 

12.5 Entire Agreement. This Agreement constitutes the entire agreement and understanding relating to the subject matter of this
Agreement and supersedes all previous communications, proposals, representations and agreements, whether oral or written, relating to the subject matter of this Agreement, including the Confidentiality and
Non-Use Agreement dated September 21, 2004, the Original Agreement and the Prior Amendments. 

12.6 Severability. If any provision of this Agreement is held to be illegal, invalid, or unenforceable under present or future laws
effective while this Agreement remains in effect, the legality, validity and enforceability of the remaining provisions will not be affected thereby. 

12.7 Waiver. Any term or provision of this Agreement may be waived at any time by the Party entitled to the benefit thereof only by a
written instrument executed by such Party. No delay on the part of Lilly or CoLucid in exercising any right, power or privilege hereunder will operate as a waiver thereof, nor will any waiver on the part of either Lilly or CoLucid of any right,
power or privilege hereunder operate as a waiver of any other right, power or privilege hereunder nor will any single or partial exercise of any right, power or privilege hereunder preclude any other or further exercise thereof or the exercise of
any other right, power or privilege hereunder. 
 12.8 Notices. All notices required or permitted to be given under this Agreement
shall be in writing and shall be deemed given upon receipt if delivered personally or by facsimile transmission (receipt verified), telexed, mailed by registered or certified mail (return receipt requested), postage prepaid, or sent by prepaid
express courier service, to the Parties at the following addresses (or at such other address for a Party as shall be specified by the notice; provided, that notices of a change of address shall be effective only upon receipt thereof): 

  
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37 

 
			
	For CoLucid:		CoLucid Pharmaceuticals, Inc.
			P.O. Box 425227
			Cambridge, Massachusetts 02142
			Attention: Chief Executive Officer
		
	With a copy to:		  
 Faegre Baker Daniels LLP

600 East 96th St.; Suite 600

Indianapolis, Indiana 46240
 Attention: Daniel L. Boeglin

Fax: 317-569-4800

		
	For Lilly:		 Eli Lilly and Company
 Lilly Corporate
Center
 Indianapolis, Indiana 46285
 United States of
America
 Attention: General Counsel
 Fax: 317-276-9152

		
	With a copy to:		  
 Eli Lilly and Company

Lilly Corporate Center
 Indianapolis, Indiana 46285

United States of America
 Attention: Vice President, LRL
Neuroscience

 12.9 Governing Law. This Agreement shall be governed by, and construed in accordance with, the
laws of the State of Indiana, United States, excluding any choice of law rules, which may direct the application of the law of any other jurisdiction. However, the scope, validity and enforceability of any patents encompassed within the scope of
this Agreement shall be determined in accordance with the applicable laws of the countries in which such patents have issued. 
 12.10
Assignability. During the term of this Agreement, neither Party shall assign any benefit or burden under this Agreement without prior written consent of the other Party, which shall not be unreasonably withheld, except that (i) either Party
may assign its rights and obligations under this Agreement to an Affiliate or to any company with which it may merge or consolidate or to any company to whom it may transfer substantially all of its assets or to any company which may acquire such
Party (including, in each case, any company created as a new vehicle upon any such merger, transfer or acquisition), (ii) CoLucid may transfer any and all of its rights to a sublicensee as provided by this Agreement and (iii) Lilly may
freely assign its royalty interest in whole or in part. This Agreement shall be binding on and inure to the benefit of the parties hereto and their respective permitted successors and assigns. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
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38 

 12.11 Jointly Prepared. This Agreement will be deemed to have been drafted by both Lilly
and CoLucid and will not be construed against either Party as the draftsperson hereof. 
 12.12 Headings, Gender and Number. All
section and article titles or captions contained in this Agreement and in any exhibit, schedule or certificate referred to herein or annexed to this Agreement are for convenience only, will not be deemed a part of this Agreement and will not affect
the meaning or interpretation of this Agreement. Words used herein, regardless of the number and gender specifically used, shall be deemed and construed to include any other number, singular or plural, and other gender, masculine, feminine, or
neuter, as the context requires. 
 12.13 Dispute Resolution. If any dispute arises relating to this Agreement, prior to instituting
any lawsuit or other dispute resolution process on account of such dispute, the Parties will attempt in good faith to settle such dispute first by negotiation and consultation between themselves, including referral of such dispute to the Chief
Executive Officer of CoLucid and the Vice President, LRL Neuroscience, of Lilly. If such executives are unable to resolve such dispute or agree upon a mechanism to resolve such dispute within sixty (60) days of the first written request for
dispute resolution under this Section 12.13, then at the request of either Party the dispute shall be submitted to non-binding mediation before a mutually acceptable mediator chosen by agreement of the parties. This provision shall not preclude
any Party from seeking immediate injunctive relief in the event such Party believes that irreparable harm will occur. 
 12.14
Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be an original, but all of which taken together shall constitute one and the same agreement. It shall not be necessary in making proof of this
Agreement or any counterpart hereof to produce or account for any of the other counterparts. 
 12.15 Schedules, Exhibits and
Attachments. All schedules, exhibits and attachments (including, without limitation, the Development Plan) referred to herein are intended to be and hereby are specifically made part of this Agreement. However, if there is a conflict between a
term or condition of such schedules, exhibits and attachments and this Agreement, the terms and conditions of this Agreement shall prevail. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
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39 

 12.16 Further Assurances. At any time during the term of this Agreement, Lilly and CoLucid
each will, at the request of the other Party, use reasonable efforts to (a) deliver to the other Party such records, data or other documents, consistent with the provisions of this Agreement, (b) execute, deliver or cause to be delivered,
all such assignments, consents, documents or further instruments of transfer or license, and (c) take or cause to be taken all such other actions, as a Party reasonably may deem necessary or desirable in order for such Party to obtain the full
benefits of this Agreement and the transactions contemplated hereby. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

40 

 IN WITNESS WHEREOF, the Parties by their
respective authorized representatives, have executed this Agreement. 
  

			
	ELI LILLY AND COMPANY
		
	By:		 /s/ Darren J. Carroll

	Printed:		Darren J. Carroll
	Title:		SVP Corporate Bus. Dev.
	
	COLUCID PHARMACEUTICALS, INC.
		
	By:		 /s/ Thomas P. Mathers

	Printed:		Thomas P. Mathers
	Title:		CEO

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

41 

 EXHIBIT A 

Licensed Patents 
 LY573144 

 

																	
	 Docket No.
	 	 Country
	 	 Status
	 	 Substatus
	 	 Application Number
	 	 Ap. Date
	 	 Patent Number
	 	 Grant Date
	 	 Expiration Date

	X14075	 	Algeria	 	Filed	 	Filed	 	40257	 	27-Mar-03	 		 		 	
	X14075	 	Argentina	 	Filed	 	Filed	 	P030101055	 	5-Mar-03	 		 		 	
	X14075	 	Australia	 	Filed	 	Filed	 	2003224719	 	27-Mar-03	 		 		 	
	X14075	 	Brazil	 	Filed	 	Filed	 	PI0308495-7	 	27-Mar-03	 		 		 	
	X14075	 	Canada	 	Filed	 	Filed	 	2478229	 	27-Mar-03	 		 		 	
	X14075	 	Chile	 	Filed	 	Filed	 	612-2003	 	26-Mar-03	 		 		 	
	X14075	 	China P.R.	 	Filed	 	Filed	 	3807363.3	 	27-Mar-03	 		 		 	
	X14075	 	Colombia	 	Filed	 	Filed	 	4096137	 	27-Mar-03	 		 		 	
	X14075	 	Costa Rica	 	Filed	 	Filed	 	7496	 	27-Mar-03	 		 		 	
	X14075	 	Croatia	 	Filed	 	Published	 	P20040883 A	 	27-Mar-03	 		 		 	
	X14075	 	Ecuador	 	Filed	 	Filed	 	04-5317-PCT	 	27-Mar-03	 		 		 	
	X14075	 	El Salvador	 	Filed	 	Filed	 	E-1691-2003	 	5-Mar-03	 		 		 	
	X14075	 	Eurasian Patent Convention	 	Filed	 	Filed	 	200401282	 	27-Mar-03	 		 		 	
	X14075	 	European Patent Convention	 	Filed	 	Published	 	3721402	 	27-Mar-03	 		 		 	
	X14075	 	Hong Kong	 	Docketed	 	Mailed	 	PCT/US03/08455	 		 		 		 	
	X14075	 	Indonesia	 	Filed	 	Filed	 	W-00200402114	 	27-Mar-03	 		 		 	
	X14075	 	Israel	 	Filed	 	Filed	 	163928	 	27-Mar-03	 		 		 	
	X14075	 	Japan	 	Filed	 	Filed	 	2003-582146	 	27-Mar-03	 		 		 	
	X14075	 	Korea South	 	Filed	 	Published	 	10-2004-7015294	 	27-Mar-03	 		 		 	
	X14075	 	Malaysia	 	Filed	 	Filed	 	PI20031097	 	5-Mar-03	 		 		 	
	X14075	 	Mexico	 	Filed	 	Filed	 	PA/A/2004/009497	 	27-Mar-03	 		 		 	
	X14075	 	New Zealand	 	Filed	 	Filed	 	534952	 	27-Mar-03	 		 		 	
	X14075	 	Nigeria	 	Granted	 	Granted	 	123/2003	 	12-Mar-03	 	RP15220	 	29-Oct-03	 	12-Mar-23
	X14075	 	Norway	 	Filed	 	Filed	 	20044654	 	27-Mar-03	 		 		 	
	X14075	 	Patent Cooperation Treaty	 	Inactive	 	National	 	PCT/US03/08455	 	27-Mar-03	 		 		 	
	X14075	 	Peru	 	Filed	 	Published	 	301	 	5-Mar-03	 		 		 	
	X14075	 	Philippines	 	Filed	 	Published	 	1-2004-501520	 	27-Mar-03	 		 		 	
	X14075	 	Poland	 	Filed	 	Filed	 	P-372845	 	27-Mar-03	 		 		 	
	X14075	 	Singapore	 	Filed	 	Filed	 	200405216-3	 	27-Mar-03	 		 		 	
	X14075	 	South Africa	 	Filed	 	Filed	 	2004/7666	 	27-Mar-03	 		 		 	
	X14075	 	Taiwan	 	Filed	 	Published	 	92106334	 	21-Mar-03	 		 		 	
	X14075	 	Thailand	 	Filed	 	Published	 	81304	 	5-Mar-03	 		 		 	
	X14075	 	Ukraine	 	Filed	 	Filed	 	20040907833	 	27-Mar-03	 		 		 	
	X14075	 	United States	 	Filed	 	Filed	 	10/509770	 	27-Mar-03	 		 		 	
	X14075	 	Venezuela	 	Filed	 	Filed	 	2003-000468	 	26-Mar-03	 		 		 	
	X14075	 	Vietnam	 	Inactive	 	Abandoned	 	1-2004-00976	 	27-Mar-03	 		 		 	
	X14075T	 	Egypt	 	Filed	 	Filed	 	289/2003	 	5-Mar-03	 		 		 	
	X14075T	 	India	 	Filed	 	Filed	 	01392/KOL/NP/04	 	27-Mar-03	 		 		 	
	X14075T	 	Pakistan	 	Filed	 	Filed	 	237/2003	 	20-Mar-03	 		 		 	

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

42 

 EXHIBIT B 

Compound Supply 
 API 

All API is transferred AS IS and CoLucid shall be solely responsible for determining its suitability for developmental or clinical trial use.

 2.5 kg LY573144 hemisuccinate manufactured and located at MSG (Belgium). 

 

	 	•	 	Material is past its re-evaluation date. 

  

	 	•	 	Material may not in any event be used for pivotal clinical trials. 

 An additional 800 g is
available that may be suitable for development use only (two lots: 200 g and 600 g), but shall not in any circumstances be used in humans. 
  

	 	•	 	Reference standard is available, but will need re-evaluation by CoLucid before use. This material was not made using cGMP. 

Analytical Methods 
 Analytical methods
have been developed and will be supplied, but not transferred. Validation will be required by CoLucid’s analytical lab prior to use. 
 Drug Product

 All Drug Product is transferred AS IS and CoLucid shall be solely responsible for determining its suitability for developmental or
clinical trial use. 
 400 unlabeled vials of the 3mg/ml CT material are available. 

 

	 	•	 	Material is past expiry dating. 

  

	 	•	 	Stability samples that may be useful to extend dating are still in stability chambers at a 3rd party and will remain until Jun-06. 

Since material was imported “Import for Export”, shipment of the material needs to comply with FD&C Act 801(d)(3). 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

43 

 EXHIBIT C 

Near Term Migraine Product Development Plan 
 Product
assumptions 
 Non-triptan, but similar efficacy. May need to prove absence of human coronary vasoconstriction with comparison to triptan for marketing.

 Potential efficacy as prophylactic migraine drug and preventive agent given at onset of aura or during prodrome. This will not be part of this proposed
development plan. 
 Need to demonstrate that nausea, vomiting, phonophobia, photophobia are improved. FDA considers pain improvement in the absence of
improvements in other features to be inadequate. 
 Can be administered IV, sublingual, or oral. 

Might have efficacy in delayed emesis. 
 Development Plan

 Migraine 
 Phase 1 studies for a new agent are
shown in Table 1. Given the thorough toxicology package that has been performed on the molecule, it is not thought that extensive additional studies will need to be performed prior to Phase 1 studies with a sublingual formulation. Preparation of a
new formulation will require an animal study to demonstrate lack of irritability of the administration and the absorption of the drug substance. Preparation of study drug is not included in the cost estimates. The Phase 1 study could potentially
compare the sublingual formulation to oral or iv doses. Assuming the data from the study is clean, Phase 2 could proceed. There is a possibility that additional studies will be required to examine any cardiac issues. For marketing reasons, these
might be helpful. 

  
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44 

 Phase 2 studies for acute migraine (moderate to severe) are shown in Table 2. The Phase 2 study would include an
initial study to determine the maximum tolerated dose and the second study would be a proof-of-concept study. A multiple dose study is also planned. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
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45 

 Delayed Emesis 

Since delayed emesis will be submitted to a different division, it is likely that that division would request a full ICH exposure in that indication. This
could be discussed and a smaller exposure might be negotiated. 
 The Phase 2 studies for delayed emesis are shown in Table 3. 

Fastest Route to Efficacy Study in Migraine 
 Given that
animals have been dosed in a regulatory 2 week intravenous study defining a NOAEL dose and that an intravenous study has been done in subjects defining the PK in man and that the dosage form planned for use in man is sublingual (or oral), the first
clinical pharmacology study will be single dose escalation to find the maximal tolerated dose in man. There would be a minimum of two groups of 8 subjects, each dosed at two dosage levels. The kinetics of the sublingual dosing should be compared to
the IV dosing as the study progresses to help define the maximal tolerated dose. You will notice in the table below that there are additional arms of the study, which would likely be beneficial. If the clinical trials use multiple dosing, a multiple
dose clinical pharmacology trial will be required to demonstrate pharmacokinetics and safety at steady state. 
 The POC clinical study would be in moderate
to severe acute migraine which will use a single dose. Patients who meet the study criteria are given blinded study drug to take with their next moderate or severe migraine headache. They subsequently complete a diary recording the severity of their
symptoms at defined times over the next several hours. This study would use study drug at the maximum tolerated dose and placebo. Efficacy in this trial would be sufficient to move forward. 

Fastest Route to Efficacy Study in Delayed Emesis 
 This
study will require toxicology support for at least 2 weeks. In addition, to the single dose preclinical pharmacology trial, a clinical pharmacology study in subjects dosed to maximum tolerated efficacy dose in steady state will be needed. An
efficacy study requiring up to 1 week of dosing should be sufficient for a proof of concept trial. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

46 

 Table 1. Projected Clinical Phase 1 Plan for Registration 

 

							
	 Study/Objective
	  	 Design
	  	 Duration
	  	N
	Absolute bioavailability	  	Crossover IV versus sublingual or oral, kinetics	  	Single dose	  	16
				
	Multiple dose	  	Parallel, include QTc evaluation, steady state kinetics	  	1 week	  	24
				
		  	** Studies could potentially be combined into one multiple dose study looking at kinetics	  		  	
				
	Subtotal:	  		  		  	
				
	Drug interaction studies (several of these depending upon characteristics of drug)	  	“Crossover”, These would include analgesics, prophylaxis agents, chemotherapeutic agents, etc. that will be used concomitantly with this formulation	  	Single dose?	  	24
				
		  	** This study of drug interaction will likely have to be performed.	  		  	
				
	Subtotal:	  		  		  	
				
	QTc trial in migraineurs	  	Cross-over, dose response, efficacy	  	Multiple single doses	  	160
				
	Cardiac catheterization for CA constriction (absence)	  	Parallel, dose response, placebo-controlled, include QTc – this should only be performed after consultation with the FDA on the ability to get a differentiating label	  	Single dose	  	48
				
		  	** These studies may be required depending on how the cardiac evaluation looks in the first two studies above. Based on the Phase 1 conducted and the clean Dog CV study, this should not be the case.	  		  	

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

1 

 Table 2. Phase 2 Clinical Plan for Migraine 

 

									
	 Phase / Indication
	  	 Study/Objective
	  	 Design
	  	 Duration
	  	 Number of
patients

	Phase 2 / Moderate/severe migraine HA pain #1	  	Dose response efficacy study (3 doses: X, 2X, & 4X) and Safety	  	Parallel, placebo controlled, include QTc evaluation	  	Single migraine, consider follow-up data to confirm safety.	  	4 X 60 = 240
					
	Phase 2 / Moderate/severe migraine HA pain #2	  	Dose response efficacy study (use best dose from study #1 and up to 4 other doses) and Safety	  	Parallel, placebo controlled, include QTc evaluation	  	Single migraine, consider follow-up data to confirm safety.	  	5 X 60 = 300
					
	Phase 2 / Repeated dose migraine study	  	Efficacy and safety	  	Parallel, comparator and placebo controlled. Consider imbalance (2:1:1). Second dose in nonresponders.	  	 Single HA
 Alternatively could treat 2-3
migraines.
	  	4 X 100 = 400

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

2 

 Table 3. Phase 1B/2 Studies for Delayed Emesis indication Submission without a migraine package 

 

									
	 Phase / Indication
	 	 Study/Objective
	 	 Design
	 	Duration	  	 Number of

patients

	Phase 1B / Proof of concept	 	Stand alone	 	Parallel, MTD vs. placebo	 	1-2 weeks	  	2 X 50 = 100
					
	Phase 1B / Proof of concept	 	Add-on to standard therapy	 	Parallel, MTD vs. placebo	 	1-2 weeks	  	2 X 50 = 100
					
	Phase 2 / Dose response a	 	Efficacy	 	Parallel, 3 doses vs. placebo	 	1-2 weeks	  	4 X 100 = 400
					
	Phase 2 / Dose response a	 	 Efficacy/Add on to

standard therapy
	 	Parallel, 3 doses vs. placebo	 	1-2 weeks	  	4 X 100 = 400

 This plan assumes that the dosage will be similar to that of migraine and that the FDA will accept safety data in migraine to
permit a reduced number of exposures. 

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

3 

 EXHIBIT D 

KNOW-HOW 
  

					
	 ADME
	  	 	  	 
	1	  	LY573144 ADME Summary Slides.ppt	  	ADME Summary Slides
			
	2	  	LY573144 011D03 EX.doc	  	Elimination of Radioactivity from Female Beagle Dogs Following Either a Single Intravenous Dose or a Single Oral Dose of 6 mg/kg [14C]LY573144 as the Hemisuccinate
			
	3	  	ID	  	File Name
			
	4	  	LY573144 ADME 011D03 PK.doc	  	Plasma Pharmacokinetics of Radioactivity and LY573144 and Red Blood Cell Distribution in Female Beagle Dogs Following a Single Intravenous or Oral Dose of 6 mg/kg of [14C]LY573144 as the Hemisuccinate
			
	5	  	LY573144 ADME C14 SYN Rpt.doc	  	Synthesis of 2,4,6-Trifluoro-N-[6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl-[2,6-14C2]]benzamide Hemisuccinate, LY573144-[14C2] Hemisuccinate
			
	6	  	LY573144 ADME Rpt 011D03 Metab.doc	  	Metabolism of LY573144 in Female Beagle Dogs Following a Single Intravenous or a Single Oral Dose of 6 mg/kg [14C]LY573144·Hemisuccinate
			
	7	  	LY573144 ADME Rpt 02.doc	  	In Vitro Metabolism of LY573144 Studied in Liver Microsomes and Cryopreserved Hepatocytes from Human, Rat, Dog, and Monkey, and In Vivo Metabolism Studied in Plasma from Rat, Dog, and Monkey and in Urine from Rat and
Dog
			
	8	  	LY573144 ADME Rpt 03.doc	  	Plasma Toxicokinetics of LY573144 in Fischer 344 Rats Following Intravenous Infusion of 4, 12, or 40 mg/kg/day LY573144 Hemisuccinate for 14 Days
			
	9	  	LY573144 ADME Rpt 04.doc	  	Toxicokinetics of LY573144 in Beagle Dogs Following a Single Intravenous Infusion of 2, 6, or 15 mg LY573144 Hemisuccinate/kg for 14 Days
			
	10	  	LY573144 ADME Rpt 05.doc	  	Drug Effects on Hepatic Microsomal Drug Metabolizing Enzymes in Beagle Dogs Given LY573144 Hemisuccinate by Intravenous Infusion for 2 Weeks
			
	11	  	LY573144 ADME Rpt 06.doc	  	Toxicokinetics of LY573144 in Gravid New Zealand White Rabbits Following a Single Intravenous Infusion of 5, 10, or 20 mg/kg LY573144 Hemisuccinate on Day 11 of Gestation
			
	12	  	LY573144 ADME Rpt 07.doc	  	Toxicokinetics of LY573144 in Gravid New Zealand White Rabbits Following a Single Intravenous Infusion of 5, 10, or 20 mg/kg LY573144 Hemisuccinate on Day 11 of Gestation
			
	13	  	LY573144 ADME Rpt 08.doc	  	Plasma Toxicokinetics of LY573144 in Gravid CD Rats on Day 12 of Gestation Following Daily Intravenous Infusions of 5, 15, or 75 mg/kg LY573144 as the Hemisuccinate Salt on Gestation Days 6 through
12

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

1 

					
			
	14		LY573144 ADME Rpt 09.doc		In Vitro Interaction of LY573144 with Human Cytochromes P450 CYP3A, CYP2D6, CYP2C19, CYP2C9, and CYP1A2
			
	15		LY573144 ADME Rpt 10.doc		Synthesis of 2,4,6-Trifluoro-N-[6-[(1-methyl-4-piperidinyl)carbonyl]-2-pyridinyl-[2,6-14C2]]benzamide Hemisuccinate, LY573144-[14C2] Hemisuccinate

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

2 

					
	 ID

Toxicology
	  	 File Name
	  	 Document Title

	1	  	LY573144 Toxicology Summary Slides.ppt	  	Toxicology Summary Slides
			
	2	  	Genpharm01 Receptor.pdf	  	Receptor Pharmacology Study of LY517717 Difumarate Using Radiolabeled Receptor Binding and Isolated Tissue-Bath Preparations
			
	3	  	Genpharm02 HERG.pdf	  	Human Cardiac IKr (HERG) Blocking Profile of Compound 517717 Hydrochloride
			
	4	  	Genpharm03 respiratory.pdf	  	Effect of Single-Dose Oral Administration of LY517717 Difumarate on Respiratory Patterns of Male Rats
			
	5	  	Genpharm04 CNS.pdf	  	CNS/Behavioral Effects of Single-Dose Oral Administration of LY517717 Difumarate in Male CD-1 Mice
			
	6	  	Genpharm05 CV.pdf	  	Telemetry Cardiovascular Assessment Study in Conscious Rats of Orally Administered Compound LY517717 Difumarate
			
	7	  	Genpharm06 hemolysis.pdf	  	Hemolytic Potential and Blood Compatibility Testing with LY573144 Hemisuccinate
			
	8	  	Tox01 single_dose.pdf	  	A Single-Dose Toxicity Study in Fischer 344 Rats Given LY573144 Hemisuccinate Intravenously
			
	9	  	Tox02 in vitro ocular.pdf	  	Bovine Corneal Opacity And Permeability Assay LY573144 Hemisuccinate (Compound 683974) Final Report
			
	10	  	Tox03 Micronucleus.pdf	  	The Effect of LY573144 Hemisuccinate Given Intravenously for 2 Consecutive Days on the Induction of Micronuclei in Bone Marrow of ICR Mice
			
	11	  	Tox04 Chrom Ab.pdf	  	The Effect of LY573144 Hemisuccinate on the In Vitro Induction of Chromosome Aberrations in Chinese Hamster Ovary Cells
			
	12	  	Tox05 Ames.pdf	  	The Effect of LY573144 Hemisuccinate on the Induction of Reverse Mutations in Salmonella typhimurium and Escherichia coli Using the Ames Test
			
	13	  	Tox06 Repeat_dose rat.pdf	  	A 2-Week Intravenous Infusion Toxicity Study of LY573144 Hemisuccinate (Compound 683974) in the Fischer 344 Rat
			
	14	  	Tox08 Repeat_dose Dog.pdf	  	A 2-Week Intravenous Infusion Toxicity Study of LY573144 Hemisuccinate in the Beagle Dog
			
	15	  	Tox09 embryofetal rat.pdf	  	An Embryo-Fetal Development Study of LY573144 Hemisuccinate (Compound 683974) Administered by Intravenous Infusion in the Rat and Companion Blood Level Study
			
	16	  	Tox10 embryofetal rabbit.pdf	  	An Embryo-Fetal Development (Segment II) Study of LY573144 Hemisuccinate (Compound 683974) Administered Intravenously in the New Zealand White Rabbit

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

3 

					
	 ID

Discovery
	  	 File Name
	  	 Document Title

	1	  	LY573144 Discovery Summary Slides	  	Discovery Summary Slides
			
	2	  	5HT1F_Candidate Selection Document	  	Candidate Selection Document—Description of all Preclinical Work

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

4 

					
	 ID

Clinical
	  	 File Name
	  	 Document Title

	1	  	LY573144 Clinical Summary Slides.ppt	  	Clinical Summary Slides
			
	2	  	5HT1F CIB.pdf	  	Current CIB
			
	3	  	frLACA 27_05_04.doc	  	Phase 1 Clinical Study LACA Final Study Report

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

5 

					
	 ID

CMC
	  	 File Name
	  	 Document Title

	1	  	LY573144 CMC Summary Slides.ppt	  	CMC Summary Slides
			
	2	  	Summation of Analytical Methods and Reports.pdf	  	Summary Index of Hard Copy Files
			
	 Analytical
Methods
	  	 	  	 
	1	  	B09352_1.pdf	  	HPLC DETERMINATION OF LY573144 IN TOXICOLOGY FORMULATIONS
			
	2	  	B09626_1.pdf	  	HPLC DETERMINATION OF LY573144 FROM TEXWIPE SWABS
			
	3	  	B09979_1.pdf	  	HPLC DETERMINATION OF LY573144 FROM TEXWIPE SWABS
			
	4	  	TR16JUL2003RZ38451A.pdf	  	Validation Protocol For Method B09979, HPLC Determination of LY573144 on Cleaning Swabs
			
	 API
	  	 	  	 
	1	  	GMP Campaign 1 development report.pdf	  	GMP Campaign 1 : development report.
			
	2	  	LY573144 hemisuccinate analytical methods and unofficial results.pdf	  	LY573144 Hemisuccinate (683974). Analytical methods and non-official results.
			
	3	  	Optimisation and robustness study on last step.pdf	  	Optimisation and robustness study on the last step of synthesis of 5-HT1f 3rd gen candidate : M026-A13
			
	4	  	Pilot plant campaign 1 production report.pdf	  	LY683974 (M026-A13 0.5 SUC) Pilot Plant campaign 1 Production report
			
	5	  	TR11OCT2002YA00275A.pdf	  	Biopharmaceutical Properties for Program 5HT1f 3rd Generation
			
	6	  	TR25MAR2002YA00275A.pdf	  	Biopharmaceutical Properties and Salt Selection for Program 5HT1f 3rd Generation
			
	 Formulation
	  	 	  	 
	1	  	TR04FEB2004RZ38452A.PDF	  	LY573144 Formulation Development Report I: Parenteral Solution Formulation, 1mg/ml, for First Human Dose Studies
			
	2	  	TR10JUN2004RZ38452A.PDF	  	LY573144 Formulation Development Report III: Parenteral Solution Formulation, 3mg/ml, for First Human Dose Studies
			
	3	  	TR10Jun2004RZ38452B.PDF	  	LY573144 Formulation Development Report II: Drug and Excipient Compatibility Study
			
	4	  	TR10NOV2003RZ38452B.PDF	  	Prediction of Bitter Taste of LY573144 Using a Rat Behavioral Taste Model
			
	5	  	TR14SEP2004RZ38452A.PDF	  	LY573144 Formulation Development Report IV: Prototype Sublingual Tablet Formulation Development and In Vivo Absorption in Dogs
			
	6	  	TR31JUL2002RZ38452A.PDF	  	Microbial Challenge Testing of LY573144 Hemisuccinate Salt (LY683974) solution for injection

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

6 

					
	 Specifications
	  	 	  	 
	1	  	specs for 3 mg per ml DP.pdf	  	Specification approval for 3 mg/ml drug product
			
	2	  	specs for API and 1 mg per ml DP.pdf	  	Specification approval for API and 1 mg/kg drug product

  
 CONFIDENTIAL TREATMENT REQUESTED

 [*] = Certain confidential information contained in this document, marked with brackets, has been omitted and filed separately with the Securities
and Exchange Commission pursuant to a request for confidential treatment pursuant to, as applicable, Rule 406 of the Securities Act of 1933, as amended, and Rule 24b-2 of the Securities Exchange Act of 1934, as amended. 

7EX-10.11

 Exhibit 10.11 

(1) PCAS Group 
 - and - 

(2) CoLucid Pharmaceuticals, Inc. 
  

 
 Master Services Agreement 

 
  

 THIS MASTER SERVICES AGREEMENT (“Agreement”) is made effective as of the 11th day of July, 2014
(“Agreement Date”). 
 BETWEEN: 
  

	 	(1)	PCAS Group, BP 181 - 23 Rue Bossuet, Z.I. La Vigne aux Loups 91160 Longjumeau - France (which with its Affiliates as defined below, will be referred to as “PCAS”) and 

 

	 	(2)	CoLucid Pharmaceuticals, Inc., a company incorporated under the laws of Delaware, whose corporate office address is c/o Pappas Ventures, 2520 Meridian Parkway, Suite 400, Durham, NC 27713 (“COLUCID”),

 Hereinafter, PCAS and COLUCID may be referred to jointly as the “Parties” or individually as a “Party”. 

WHEREAS, COLUCID is the owner of certain proprietary compounds and wishes to engage PCAS to manufacture and/or package, label and store for COLUCID a certain
compound referred to as COL-144 (lasmiditan) and/or certain of its intermediates, or develop synthesis processes as from time to time requested by COLUCID; 

WHEREAS, PCAS is a contract manufacturer that possesses the necessary technical capabilities, expertise and facilities for the manufacture of certain active
pharmaceutical ingredients, and is willing to perform Services for COLUCID as described in Work Orders and as specified in this Agreement; 
 NOW THEREFORE,
in consideration of the mutual representations, warranties and covenants contained herein and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged by each Party, the Parties hereby agree, intending to
be legally bound, as follows: 
  

	1.	DEFINITIONS. 

 As used in this Agreement, the following terms shall have the following meanings: 

 

			
	 “Affiliate”
		with respect to a company shall mean any other entity or person that directly, or indirectly through one or more intermediaries, controls, is controlled by or is under common control with such company; “control” and,
with correlative meanings, the terms “controlled by” and “under common control with”, shall mean (a) the possession, directly or indirectly, of the power to direct the management or policies of a company, whether through the
ownership of voting securities, by contract or otherwise, or (b) the ownership, directly or indirectly, of at least fifty percent (50%) of the voting securities or other ownership interest of a company.

  
 1 

			
	 “Business Day”
		shall mean every day of the week except Saturday, Sunday and a nationally recognized holiday of either France, or the USA.
		
	 “Certificate of Analysis”
		shall mean a certificate of analysis prepared by PCAS for each delivery of a Product, as applicable, to prove compliance with the Specifications.
		
	 “COLUCID Intellectual Property”
		shall have the meaning set forth in Section 5.
		
	 “Compound”
		shall mean COL-144 (lasmiditan) active pharmaceutical ingredient and/or any other small molecule compound with the chemical structure provided by COLUCID for the purpose of the provision of Services by PCAS.
		
	 “Confidential Information”
		shall have the meaning set forth in Section 4 of this Agreement.
		
	 “Disclosing Party”
		shall have the meaning set forth in Section 4 of this Agreement.
		
	 “cGMP”
		(current Good Manufacturing Practices) means the current good manufacturing practices described in U.S. 21 CFR, Parts 210 et seq., as amended and any similar requirement of other jurisdictions, including without limitation ICH
and EU GMP requirements.
		
	 “Product”
		shall mean the physical batches of COL-144 API (lasmiditan) resulting from the Services.
		
	 “Project”
		shall mean the Services performed under a specific Work Order.
		
	 “Project Coordinators”
		shall have the meaning set forth in Section 2.4 of this Agreement.
		
	 “Project Manager”
		shall mean the project leader appointed by each Party who shall be the primary point of contact for the other Party on issues related to the Services.
		
	 “Proposal”
		shall mean a written description or protocol mutually agreed between the Parties and signed by both Parties describing the Services to be performed by PCAS, including but not limited to the agreed upon scope of work provided or
approved by COLUCID, such as the quantities of material to be manufactured and/or packaged, the Specifications and the envisaged manufacturing dates of same.

  
 2 

			
	 “Purchase Order”
		shall mean a purchase order signed by the COLUCID ordering specific Services pursuant to a Work Order.
		
	 “Quality Agreement”
		shall mean the agreement regarding quality standards as described in Section 2.11.
		
	 “Quotation”
		shall mean a quotation issued by PCAS in connection with a Proposal.
		
	 “Receiving Party”
		shall have the meaning set forth in Section 4 of this Agreement.
		
	 “Report(s)”
		shall mean all documentation required by the Work Order and Specifications regarding the Product and Services performed under this Agreement and all regular updates and status reports provided by the Project Manager in accordance
with Section 2.5.
		
	 “Services”
		shall mean the particular services that PCAS is obligated to furnish to COLUCID as described in a Work Order. The services covered by this Agreement may be custom chemical synthesis, chemical process research, chemical process
development, scale-up studies, chemical manufacturing, regulatory, clerical, project management, laboratory services, including analytical development and quality control testing, and other appropriate research, development and manufacturing
services requested by COLUCID and agreed to by PCAS.
		
	 “Specifications”
		shall mean the GMP requirements, procedures, process parameters, analytical tests and other attributes and written specifications for the Product, which the Parties agree are necessary for the manufacture and release of the
Product for use in clinical trials. Specifications will be specified in the respective Work Order and shall include the quality specifications contained in the Quality Agreement. The Parties recognize that the specifications in a specific Work Order
may change during the term of the applicable Project, as agreed by the Parties. Copies of the Specifications (including any amendments thereto) shall be maintained by both Parties and shall be incorporated by reference herein.

  
 3 

			
	 “Work Order”
		shall mean a written description of the Services to be performed by PCAS for COLUCID pursuant to this Agreement, including the applicable scope of work, Reports, Specifications, delivery dates and compensation relating to such
Services. Each Work Order shall be substantially in the form provided in APPENDIX A or in the form of a Proposal, and shall be executed by both COLUCID and PCAS.

 The Section and Appendix headings are for convenience only and shall not affect the interpretation of this Agreement. 

References to Sections are to Sections in the main body of this Agreement, and references to Paragraphs are to Paragraphs of the Schedules. 

References to the singular include the plural and vice versa, and references to one gender include the other gender. 

 

	2.	SCOPE OF SERVICES. 

  

	2.1	From time to time during the term of this Agreement, PCAS and COLUCID may enter into one or more Work Orders for certain specified Services. The Parties will initiate specific Services by agreeing on a Proposal or other
Work Order. COLUCID may then issue a Purchase Order solely for administrative purposes. No Purchase Order, Quotation, or invoice, including the terms and conditions therein, shall be deemed to vary the terms of this Agreement or any agreed Work
Order. If the terms of a Work Order conflict with the terms of this Agreement, the terms of this Agreement will control, unless this Agreement expressly allows a Work Order to modify a specific term and the Work Order clearly expresses the
Parties’ intent to do so. Work Orders expire according to their own terms or, if not specifically stated, on the date the particular work is completed. Each Work Order for Services to be performed by PCAS for COLUCID under this Agreement shall
be incorporated by reference and be attached hereto as consecutively numbered Appendices A. Changes to an existing Work Order (including accepted Proposals that serve as a Work Order) must be evidenced by a new or amended Work Order executed
by both Parties. 

  

	2.2	PCAS shall perform all Services in accordance with the applicable Work Order, Quality Agreement and Specifications at the development and manufacturing facilities specified in the relevant Work Order. Unless otherwise
agreed in writing with COLUCID, all Compounds and Product manufactured by PCAS for COLUCID and delivered to COLUCID shall conform to the relevant Specifications outlined in the applicable Work Order. PCAS shall, upon request, produce for COLUCID
specified quantities of Compounds and manufacture, supply, package and deliver to COLUCID the resulting Product, Report and related documentation within the Services and provide such other Services as are described in the applicable Work Order.

  
 4 

	2.3	PCAS will comply with all applicable laws, regulations and professional and industry standards relating to the provision of the Services, including without limitation, cGMP where applicable. PCAS will ensure that its
staff employed in providing the Services has the necessary skills and training and the facilities and equipment necessary to provide the Services in accordance with industry standards. PCAS will complete the work and deliver the Product on the
delivery date specified in the applicable Work Order. 

  

	2.4	The Services shall be managed by a senior level technical manager at PCAS named in the Work Order as Project Manager. In addition, the Parties shall appoint employees responsible for coordination of individual types of
Services (the “Project Coordinators”). The Project Coordinators shall be the persons named in the Work Order or otherwise specified in writing to the other Party. COLUCID will be able to meet and communicate directly with the PCAS Project
Manager and the Project Coordinators. 

  

	2.5	The Project Manager shall be responsible for providing regular updates to COLUCID (at mutually agreed intervals and in mutually agreed formats) detailing the current status of Services performed, the Services completed
and Services to be performed for each Project. All such reports shall be in English and PCAS shall draft minutes of each meeting/teleconference for review by COLUCID, with the final version of such minutes to be agreed upon by email within five
Business Days after the meeting/teleconference. PCAS shall use reasonable efforts to retain the Project Manager and the Project Coordinators for the duration of the Project(s). In the event the Project Manager or the Project Coordinators cannot be
retained, PCAS will notify COLUCID without undue delay. 

  

	2.6	All Products and materials shipped by PCAS will be shipped in compliance with applicable laws, the Work Order and any applicable Specifications, [F.C.A. COLUCID’s facilities or a third party designee specified in
the applicable Work Order] (as such term is defined by Incoterms 2000). Absent specific instructions from COLUCID, PCAS will select the carrier and ship freight prepaid, with the cost thereof charged to COLUCID. PCAS will bear the risk of loss for
all Products and materials associated with the Services from the time delivered to PCAS’s facility or manufactured by PCAS (as applicable) until the Product or material is delivered to [COLUCID or to the designated facility specified in the
applicable Work Order], including any cost of insurance for such Products and materials, risks in transit, and risks associated with customs delays, storage, and handling. In the event that COLUCID wishes PCAS to store the Product, both Parties will
sign the storage agreement attached as Appendix C. 

  

	2.7	PCAS will store the Compound as specified in the Specifications, the applicable Work Order and the Quality Agreement. PCAS will keep COLUCID’s title to all Compound, work-in-process and Products in PCAS’s
custody free and clear of all liens and encumbrances. PCAS will not use the Compound or any materials provided by COLUCID for any purpose other than the performance of the Services. 

  
 5 

	2.8	PCAS shall provide a Certificate of Analysis (and any required Report, such as a Campaign Report) to COLUCID or its designated agent with each shipment of supplied Product made hereunder. Such Certificate of Analysis
shall certify with respect to each shipment and lot (identified by batch/lot or control number): (I) the quantity of the shipment and (ii) that the Product delivered was manufactured in accordance with the Specifications, cGMPs (as
applicable) and the master batch records (if applicable) and documented according to requirements of laws, rules and regulations and applicable production SOP’s as specified in the applicable Work Order. 

 

	2.9	At its own expense, PCAS will create and maintain all records (a) required by this Agreement, the applicable Work Order and/or applicable laws that relate to this Agreement or the Services to be performed under
this Agreement; (b) sufficient to demonstrate that any and all amounts invoiced to COLUCID under this Agreement are accurate and proper in both kind and amount; and (c) sufficient to demonstrate the accuracy of any representations or
reports submitted to COLUCID under this Agreement. All such records shall be true and accurate. PCAS will maintain all such records for the longest of the following retention periods that applies; (I) any period prescribed by applicable laws or
expressly stated in this Agreement; (ii) for records related to invoices, for three years after payment of the invoice by COLUCID, (iii) for records related to reports submitted to COLUCID, for seven years after the report is submitted;
and (iv) for all records not addressed by one of the above, for seven years after the term of this Agreement. 

  

	2.10	If COLUCID or its designee reasonably deems that any Report or Products delivered to COLUCID hereunder fail to conform to the Specifications, then COLUCID or its designee shall notify PCAS thereof in writing (the
“Deficiency Notice”). COLUCID or its designee shall retain the non-conforming Products and Report, and PCAS shall have the right to inspect such Products. COLUCID will notify PCAS of any latent defects, which are attributable to an act or
omission of PCAS and cause a Product to fail to conform but that are not evident upon reasonable inspection at the time of delivery, in a Deficiency Notice within a reasonable period after discovery of the latent defect. 

If PCAS receives a Deficiency Notice it will, at COLUCID’s discretion, either (i) replace, as quickly as possible, any such Products
with an equal quantity of Products complying with the Specifications given in the applicable Work Order (and correct and replace the Report) at no additional cost to COLUCID or (ii) refund any payments made by COLUCID for the Product. 

If PCAS disagrees with COLUCID’s determination that a Product is non-conforming, then PCAS may retest the Product at its own expense. If
the rejected Product complies with the Specifications based upon the results of PCAS’s retest, PCAS shall immediately notify COLUCID in writing and COLUCID and PCAS shall meet to attempt to resolve the issues of disagreement. If the Parties
cannot resolve the issue within 10 days, the Parties agree to each submit a sample (one sealed by COLUCID and one sealed by PCAS) to a mutually agreeable independent laboratory. The Parties shall have such independent laboratory analyze the samples
submitted for conformity with the Specifications. The analytical result of such independent laboratory shall be final and binding on the Parties. Costs incurred by the independent laboratory for such analysis shall be borne by the Party whose
opinion was found to be in error. 

  
 6 

 COLUCID or its designee shall dispose of any Products that are not in compliance with the
Specifications at PCAS’s cost, and in compliance with all applicable laws. In the event a material error by PCAS in the performance of the Services renders the Services invalid, PCAS shall repeat the Services upon request of COLUCID at no
additional expense to COLUCID. 
  

	2.11	Within a reasonable timeframe after the execution of this Agreement, the Parties agree to negotiate and execute a Quality Agreement with respect to the Services. Upon execution, the Parties agree that the Quality
Agreement shall be attached to this Agreement as Appendix B. In case of any conflict between the terms of the Quality Agreement and the terms of this Agreement, the terms of this Agreement shall control unless this Agreement expressly allows
the Quality Agreement to modify the inconsistent term and the Quality Agreement clearly expresses the Parties’ intent to do so. 

  

	2.12	At the completion of the Services by PCAS or upon earlier termination of this Agreement for any reason and upon written request by COLUCID, PCAS shall transfer all work in progress, together with all materials, data,
documentation, and other information that PCAS generated as part of providing the relevant Services to COLUCID, regardless of the method of storage or retrieval, in such form as is then currently in the possession of PCAS. PCAS shall ensure that any
data stored electronically or on another similar medium is permanently deleted. Notwithstanding the foregoing, PCAS may keep one copy of any documentation necessary to comply with the record requirements of Section 2.8 and for its own legal
archive. 

  

	2.13	Upon request, PCAS will, on a timely basis, provide COLUCID with all information reasonably necessary for COLUCID to comply with COLUCID’s regulatory requirements. PCAS shall fully cooperate with COLUCID, including
supplying all information, data and rights of reference required by COLUCID, in connection with any regulatory and government filings made by COLUCID with respect to the Compounds and/or Products, at COLUCID’s expense. 

 

	3.	COMPENSATION. 

  

	3.1	Each Project will have outlined for it an invoicing structure for the specific work to be done under the applicable Work Order. PCAS may issue a Quotation for such work as part of the Proposal process. Any standard
terms and conditions referenced in such Quotations shall not apply. 

  

	3.2	 In consideration of the Services provided by PCAS under this Agreement, COLUCID will pay PCAS the compensation agreed upon in the applicable Work
Order, including any fees, expenses, taxes and pass-through costs to be paid by COLUCID as specified in the Work Order. The Parties agree that PCAS shall not include any markup or overhead on pass-through costs or expenses. All sums payable under
this Agreement shall be paid in U.S. Dollars ($). Payment will be due within thirty (30) days after COLUCID receives 

  
 7 

 
an invoice that complies with the requirements of this Agreement and any applicable Work Order. If any portion of an invoice is disputed, COLUCID will pay the undisputed amounts and the parties
will use good faith efforts to reconcile the disputed amount as soon as practicable. 
  

	3.3	The fees for Services set forth in the applicable Work Order shall include all compensation for PCAS’ full performance of the Services and all other obligations under this Agreement, with no other amounts owed to
PCAS by COLUCID for labor, materials, expenses, time of staff, overhead, profit, taxes, insurance, or other costs or pass-through expenses. Further, no line item in any budget, Proposal or Quotation shall be exceeded by PCAS without prior written
consent from COLUCID. 

  

	3.4	Invoices shall be sent by regular mail to the notice address specified in Section 12.1 below and a copy shall be sent electronically to the following e-mail addresses or to such other address as may be notified to
PCAS in writing: kkelly@colucid.com. 

  

	3.5	Except as otherwise specified in this Agreement and/or agreed in a Work Order, PCAS shall be responsible for all expenses incurred by it in providing Services and fulfilling its obligations under this Agreement or under
any Work Order. 

  

	4.	CONFIDENTIAL INFORMATION. 

  

	4.1	“Confidential Information” of a party means information or materials which have been or will be disclosed by such party to this Agreement, or such party’s agents, employees, Affiliates and representatives
(“Disclosing Party”) to the other party to this Agreement, or the other party’s agents, employees, Affiliates and representatives (“Receiving Party”). Confidential information of COLUCID shall include, without limitation,
compounds, materials, product formulations, formulas, methods, applications to governmental authorities, research programs, data, designs, techniques, processes, records, unpublished findings, trade secrets, inventions, ideas, know-how,
improvements, discoveries, developments and other intellectual property; and business plans and information regarding research and development, Products, regulatory matters, marketing and sales, budgets and financial statements, licenses, strategic
partners and Affiliates. Any and all data and results, documentation, records, Specifications, materials and reports generated as a result of the Services or generated from use of the Compounds is Confidential Information of COLUCID.

  

	4.2	The Receiving Party shall treat all Confidential Information received from the Disclosing Party as the exclusive property of the Disclosing Party. The Receiving Party agrees not to disclose any Confidential Information
to any third party without first obtaining the Disclosing Party’s written consent. The Receiving Party shall not use the Confidential Information of the Disclosing Party for any reason or purpose other than the purpose for which it was
disclosed. The Receiving Party recognizes and agrees that the Confidential Information of the Disclosing Party constitutes a valuable, confidential and proprietary asset of the Disclosing Party. 

  
 8 

	4.3	The Receiving Party agrees to limit access to the Confidential Information received hereunder to those of its employees who have a need to know of such Confidential Information for the performance of this Agreement.

  

	4.4	The Receiving Party further agrees to ensure that the obligations of confidentiality contained in this Agreement shall be imposed on the employees, which receive Confidential Information, before such receipt. The
Receiving Party shall be liable for any disclosure or use in violation of this Agreement by any person to whom it has disclosed Confidential Information. 

  

	4.5	The Receiving Party agrees to take the same measures to preserve the secrecy and confidentiality of all Confidential Information disclosed hereunder as it does in the case of its own most closely guarded confidential
information, but no less than reasonable care. 

  

	4.6	The above provisions on confidentiality shall not apply to that part of such information which the Receiving Party is clearly able to demonstrate: 

 

	 	(a)	was lawfully in its possession prior to receipt from the Disclosing Party; or has been independently and lawfully developed by the Receiving Party without the benefit, use, knowledge of or access to any Confidential
Information disclosed by the Disclosing Party, as shown by respective written records or documents; or 

  

	 	(b)	was in the public domain at the time of receipt from the Disclosing Party; or 

  

	 	(c)	became part of the public domain through no default of the Receiving Party, its Affiliates, directors, officers or employees; or 

  

	 	(d)	was lawfully received from a third party having a right of further disclosure; or 

  

	 	(e)	is required to be disclosed by law or applicable government regulations; provided that the Receiving Party immediately notifies the Disclosing Party upon becoming aware of such requirements, takes reasonable steps to
ensure confidential treatment of such information, cooperates with the Disclosing Party’s efforts to limit or prevent disclosure, and that any disclosure is limited only to the governmental agency requiring such disclosure. 

The foregoing exceptions do not apply to information that is identified as a trade secret by COLUCID. Confidential Information specific to
particular products or circumstances shall not be deemed to be within the foregoing exceptions merely because it is embraced by general disclosures regarding other products and circumstances. A combination of features shall not be deemed to be
within the foregoing exceptions merely because individual features of such combination are in the public domain or in the possession of the Receiving Party. 
  

	4.7	 The above provisions regarding confidentiality and non-use shall remain in effect during the term of this Agreement and for a period ending five
(5) years following the expiration or termination of this Agreement; provided any Confidential Information constituting a 

  
 9 

	 	
trade secret under applicable law, and identified by the Disclosing Party as a trade secret at the time of disclosure, shall continue to remain subject to these obligations for such longer period
of time as such information remains a trade secret. 

  

	4.8	The Receiving Party shall return to the Disclosing Party all Confidential Information obtained, in whatever medium of expression, and all copies or derivatives of such information, upon the termination or expiration of
this Agreement or at any time at the Disclosing Party’s request. 

  

	4.9	The Disclosing Party may be entitled to seek injunctive relief as necessary for the enforcement of this Article 4. 

  

	4.10	Except as specified in Section 5, nothing contained in this Agreement shall be deemed to grant to either Party any rights or licenses under any patent applications or patents or to any Compounds, know-how,
technology, inventions or other intellectual property rights of the other Party. 

  

	4.11	PCAS shall not publish any articles or make any written or oral presentations relating to the Services or referring to results and data generated as part of the Services, in whole or in part or referring to
COLUCID’s Confidential Information, without the prior written consent of COLUCID. 

  

	5.	INTELLECTUAL PROPERTY. 

  

	5.1	PCAS acknowledges that all work product and other information generated by PCAS in connection with the Services, including, without limitation, all rights (including any and all intellectual property rights), title and
interests in and to any material, notes, data, results, records, inventions, processes, procedures, analysis, improvements, developments, discoveries and trade secrets made, conceived, reduced to practice, or discovered in the performance of the
Services (whether or not patentable and/or copyrightable), or that incorporates or directly relates to the Compound(s), the use, manufacture or formulation thereof, or any other material, product or process belonging to COLUCID or its licensors, or
to any improvement(s), enhancement(s) or refinement(s) of any of same (collectively, the “COLUCID Intellectual Property”), shall be the sole and exclusive property of COLUCID. PCAS shall promptly and fully disclose in writing to COLUCID
any COLUCID Intellectual Property which is conceived or made solely by one or more employees of PCAS or jointly by one or more employees of PCAS and one or more employees of COLUCID as a result of performance of the Services. 

 

	5.2	PCAS agrees to assign, and hereby assigns to COLUCID, without further compensation, all rights, title and interest in and to any COLUCID Intellectual Property, throughout the world in any medium and including the right
to create derivative works thereof, irrevocably and unlimited, especially the right to file patents in the name of COLUCID and the right to commercially exploit and license the patents. PCAS shall undertake all steps necessary to effectuate this
assignment/transfer of the COLUCID Intellectual Property to COLUCID. 

  
 10 

	5.3	Without limiting the generality of the foregoing, PCAS agrees to assist COLUCID, or COLUCID’s designee, at COLUCID’s expense, to obtain and from time to time enforce and defend COLUCID’s rights in the
COLUCID Intellectual Property and any copyrights, patents or other intellectual property rights relating thereto in any and all countries, and to execute all documents reasonably necessary for COLUCID to do so. PCAS warrants that all persons
performing Services will or have assigned their rights in any COLUCID Intellectual Property to PCAS. 

  

	5.4	PCAS agrees that if COLUCID is unable because of PCAS’s or dissolution to secure PCAS’s signature to apply for or to pursue any application for any United States of America or foreign patents or copyright
registrations covering the COLUCID Intellectual Property, then PCAS hereby irrevocably designates and appoints COLUCID and COLUCID’s duly authorized officers and agents as PCAS’s agent and attorney-in-fact, to act for and in PCAS’s
behalf and stead to execute and fife any such applications and to do all other lawfully permitted acts to further the prosecution and issuance of patents and copyright registrations thereon with the same legal force and effect as if executed by
PCAS. 

  

	5.5	Notwithstanding anything contained herein to the contrary, any previously existing PCAS property or improvements thereto which may be used by PCAS in connection with the Services or during the term of this Agreement and
which do not incorporate any COLUCID Intellectual Property or Confidential Information (“PCAS Property”), shall be the sole and exclusive property of PCAS; provided, however, that if PCAS incorporates or permits to be incorporated any PCAS
Property into any of the COLUCID materials, PCAS hereby grants to COLUCID or COLUCID’s designees a non-exclusive, royalty-free, irrevocable, worldwide, fully paid-up, transferable license (with rights to sublicense through multiple tiers of
sublicensees) to use, reproduce, modify, distribute and commercially exploit such PCAS Property solely to the extent required for COLUCID to make full use of COLUCID’s materials. 

 

	6.	SAFETY. 

  

	6.1	PCAS will comply with all applicable laws, regulations and professional and industry standards concerning health, environmental and safety within its facilities, including without limitation, worker safety and labor
laws. 

  

	6.2	PCAS will generate, handle, store, ship and dispose of all wastes associated with the manufacture of COLUCID’s products and the performance of the Services in accordance with applicable laws. 

 

	6.3	If either Party shall become aware of any safety hazards that relate to any of the Compounds or Products, it shall promptly notify the other Party by providing relevant information in its possession or control
concerning such safety hazards. 

  
 11 

	7.	INDEMNIFICATION. 

  

	7.1	PCAS shall defend, indemnify and hold harmless COLUCID and its Affiliates and their respective officers, directors and employees from and against any and all claims, suits, demands, actions, causes of action,
liabilities, damages, costs and expenses (including, without limitation, interest, penalties, court costs and reasonable attorneys’ fees, accounting fees and expert witness fees) incurred by any of the foregoing in connection with any third
party claim (collectively, “Losses”) to the extent arising out of (a) any act or omission of negligence, gross negligence or willful, wanton or intentional misconduct of PCAS or its Affiliates, representatives or subcontractors in the
performance of its obligations under this Agreement; (b) any breach of PCAS’s obligations under this Agreement; (c) any claim that the Services performed by PCAS or COLUCID’s use thereof, infringes the intellectual property
rights of a third party. The foregoing obligation to indemnify shall not apply to the extent the Losses result or arise from the act or omission of negligence, gross negligence or willful, wanton or intentional misconduct of COLUCID or its
Affiliates. 

  

	7.2	COLUCID shall defend, indemnify and hold harmless PCAS and its Affiliates and their respective officers, directors and employees from and against any and all Losses to the extent arising out of (a) any act or
omission of negligence, gross negligence or willful, wanton or intentional misconduct of COLUCID or its Affiliates in the performance of its obligations under this Agreement; or (b) any breach of PCAS’s obligations under this Agreement.
The foregoing obligation to indemnify shall not apply to the extent the Losses result or arise from the act or omission of negligence, gross negligence or willful, wanton or intentional misconduct of PCAS or its Affiliates, representatives of
subcontractors. 

  

	7.3	SUBJECT TO THE EXCEPTIONS CONTAINED IN THIS SECTION, IN NO EVENT SHALL EITHER PARTY BE LIABLE TO THE OTHER PARTY OR ANY THIRD PARTY FOR ANY LOST REVENUES OR PROFITS OR ANY (A) SPECIAL, (B) CONSEQUENTIAL,
(C) PUNITIVE OR (D) INCIDENTAL DAMAGES (INCLUDING, IN EACH CASE, LOST REVENUES OR PROFITS), WHETHER OR NOT FORESEEABLE AND WHETHER OR NOT A PARTY WAS ADVISED OF SUCH LOSSES/DAMAGES IN ADVANCE, RELATING TO THIS AGREEMENT OR THE SUBJECT
MATTER HEREOF, ANY WORK ORDER OR THE SERVICES WHETHER SUCH LIABILITY IS IN CONTRACT, TORT (INCLUDING NEGLIGENCE OR BREACH OF STATUTORY DUTY) OR OTHERWISE. 

NOTHING CONTAINED HEREIN IS INTENDED TO EXCLUDE OR LIMIT ANY LIABILITY FOR (A) DEATH OR PERSONAL INJURY CAUSED BY A PARTY’S
NEGLIGENCE OR (B) FRAUD. 
 THE FOREGOING LIMITATIONS OF LIABILITY SHALL NOT APPLY TO DAMAGES RESULTING FROM PCAS’S BREACH OF ITS
OBLIGATIONS RELATED TO CONFIDENTIAL INFORMATION OR INTELLECTUAL PROPERTY CONTAINED IN SECTIONS 4 AND 5 NOR TO ANY DAMAGE ARISING OUT OF THE INTENTIONAL, WILLFUL OR WANTON MISCONDUCT OF PCAS NOR SHALL THEY LIMIT THE ABILITY OF COLUCID TO PURSUE
INJUNCTIVE RELIEF UNDER THIS AGREEMENT. 

  
 12 

	8.	REPRESENTATIONS, WARRANTIES AND COVENANTS. 

  

	8.1	Each Party represents and warrants that (a) it is duly organized, validly existing and in good standing under the laws of its jurisdiction of organization, (b) it has all requisite power and authority to
conduct its business and perform its obligations under this Agreement; (c) the execution, delivery and performance by it of this Agreement have been duly authorized and approved by all necessary action on its part; (d) this Agreement has
been duly executed and delivered by it and constitutes its legal, valid and binding obligation, enforceable against it in accordance with its terms, except as enforceability may be limited by applicable bankruptcy, insolvency or other laws relating
to or affecting creditors’ rights generally and by general equity principles, and (e) the execution of this Agreement by it and performance by it of its obligations under this Agreement will not conflict with any other agreement with any
third party to which it is a party. Each Party covenants that it shall not enter into any agreement with any third party that is inconsistent with its obligations and the rights granted to the other Party under this Agreement. 

 

	8.2	PCAS covenants that in performing the Services PCAS shall not, to the best of PCAS’s knowledge, infringe any patents or other intellectual property rights held by any third party; provided, however, that PCAS will
not be liable for infringement arising solely due to specifications and instructions received from the COLUCID that PCAS did not know infringed the intellectual property rights of another party. 

 

	8.3	PCAS represents and warrants that it has the right to make any grants of intellectual property rights to the work product or other deliverables that it makes or is required to make under this Agreement.

  

	8.4	PCAS represents and warrants that all work product created by PCAS for COLUCID under this Agreement is an original creation for COLUCID unless COLUCID acknowledges otherwise in the Specifications or another writing.

  

	8.5	PCAS represents and warrants that it shall perform the Services in a professional and workmanlike manner and in compliance with all applicable laws (including cGMP as applicable), regulations, professional standards,
the Specifications and the terms of this Agreement. 

  

	8.6	PCAS represents and warrants that all Products manufactured by PCAS under this Agreement shall be manufactured, tested, stored and transported in conformance with the Specifications mutually agreed in the relevant Work
Order, and with relevant applicable laws related to the specific service and guidelines in all relevant countries, including cGMPs, as the same may be amended or revised from time to time. 

 

	8.7	PCAS represents and warrants that it will not use the Compound(s) or any materials provided by COLUCID for any purpose other than the performance of the Services and will not manufacture or supply Products for any third
party or any use other than as directed by COLUCID in writing. 

  
 13 

	8.8	COLUCID represents and warrants that the performance of COLUCID’s responsibilities under this Agreement, and COLUCID’s use of the Services and Products, will comply with all applicable laws. 

 

	9.	USE OF NAMES. 

 Except as required by applicable law or regulation, neither Party shall
use the name or logo of the other Party, nor of any employee of the other Party, in connection with any publicity or promotional material, without the prior written approval of the other Party. 

 

	10.	TERM AND TERMINATION. 

  

	10.1	The term of the Agreement shall commence as of the Agreement Date and continue five (5) years from the Agreement Date, unless earlier terminated or canceled in accordance with this Section 10. Notwithstanding
the foregoing, if any Work Orders are in effect on the day that this Agreement would otherwise expire, then this Agreement will remain in effect solely for the purpose of those Work Orders until their respective expiration, cancelation or
termination. The initial term of this Agreement may be extended by mutual written consent of both Parties. 

  

	10.2	COLUCID shall have the right to terminate or cancel this Agreement or an individual Project at its sole discretion and without cause upon thirty (30) days’ prior written notice to PCAS. In the event of such
termination or cancellation, PCAS will use its best efforts to mitigate costs during the notice period, and COLUCID will pay PCAS for all Services performed up to the date of termination and reasonable non-cancelable costs incurred in connection
with the Services, in accordance with the terms of this Agreement and the applicable Work Order. If payments made by COLUCID for a Project exceed the amount owed for Services performed before the Project’s termination or cancellation, PCAS
agrees to return the excess balance to COLUCID. 

  

	10.3	This Agreement may be terminated by a Party, without prejudice to other rights or remedies available under this Agreement or by law, by giving written notice to the other Party in the event of a material breach by the
other Party of its obligations under this Agreement, unless such breach is cured by the breaching party within thirty (30) days after written notice of breach has been given to it. 

 

	10.4	Either Party may terminate this Agreement, upon written notice to the other Party, in the event that the other Party has (a) commenced a voluntary proceeding under any insolvency law, or (b) had an involuntary
proceeding commenced against it under any insolvency law which has continued undismissed or unstayed for 60 consecutive days, or (c) had a receiver, trustee or similar official appointed for it or for any substantial part of its property, or
(d) made an assignment for the benefit of creditors, or (e) had an order for relief entered with respect to it by a court of competent jurisdiction under any insolvency law. For purposes hereof, the term “insolvency law” means
any applicable bankruptcy, insolvency or other similar law now or hereafter in effect. 

  
 14 

	10.5	Upon termination, cancellation or expiration of this Agreement for any reason regardless of cause, PCAS shall deliver all materials, copies of information and data owned by COLUCID including data generated by PCAS for
COLUCID under this Agreement, regardless of the method of storage or retrieval, to COLUCID in such form as is then currently in the possession of PCAS, and PCAS shall ensure that any data stored electronically or on another similar medium is
permanently deleted. PCAS reserves the right to retain, at its cost and subject to the confidentiality provisions herein, materials, information or data that are required to satisfy regulatory or other legal requirements. 

 

	10.6	Upon termination, cancellation or expiration of this Agreement and request by COLUCID, PCAS will cooperate in transferring PCAS’s obligations and any work in progress to COLUCID or COLUCID’s designated third
party supplier, including reasonable assistance to COLUCID in qualifying a third party manufacturer. As part of PCAS’s duty to cooperate, PCAS agrees to provide to COLUCID or a third-party designated by COLUCID, at COLUCID’s request, a
full inventory of all work in progress, together with all COLUCID Intellectual Property (including without limitation all, data, documentation, and other information that PCAS generated as part of providing Services to COLUCID). All such assistance
and cooperation shall be free of charge if the termination of this Agreement or applicable Work Order is due to a breach by PCAS. 

  

	10.7	The termination, cancelation or expiration of this Agreement shall not relieve either Party of any obligations that are expressly indicated to survive termination and shall be without prejudice to any rights that shall
have accrued to the benefit of any Party prior to such termination or expiration. The rights and obligations of COLUCID and PCAS, which by intent or meaning have validity beyond termination, cancelation or expiration of this Agreement (including
without limitation, rights with respect to inventions, discoveries and improvements, confidentiality, indemnity and limitations of liability) shall survive the termination, cancelation or expiration of this Agreement or any Work Order.

  

	10.8	PCAS acknowledges and agrees that neither the termination, cancelation nor expiration of this Agreement shall affect in any manner COLUCID’s right to manufacture and sell or have manufactured and sold the Product.

  

	11.	FORCE MAJEURE. 

  

	11.1	If the performance of this Agreement or any obligation under this Agreement (except for the payment of any sum of money) is prevented, restricted or interfered with by reason of any circumstances beyond the reasonable
control of the Parties (such as government action, war, fire, explosion, flood, strike, lockout, embargo or act of God) then the Party so affected shall, upon giving prompt notice in writing to the other Party, be excused from such performance or
obligation to the extent of and for the duration of such prevention, restriction or interference. Any payment obligations relating to periods of excused performance shall also be excused and any advance payments for periods of excused performance
shall be refunded or credited. 

  

	11.2	If any of the circumstances described in Section 11.1 prevails for a continuous period in excess of six (6) months, the Parties hereto shall enter into good faith discussions with a view to alleviating its
effects, or to agreeing upon such alternative arrangements as may be fair and reasonable in all of the circumstances. 

  
 15 

	11.3	Nothing in this Section 11 shall affect COLUCID’s right to cancel or terminate this Agreement in accordance with Section 10. 

 

	12.	MISCELLANEOUS 

  

	12.1	Notices. 

  

	 	12.1.1	Any notice or other communication required to be given under this Agreement shall be in writing in the English language and shall be sent by pre-paid airmail or courier or by fax or email to the address, fax number or
email address set out below or to such other address, fax number or email address as may from time to time be notified to the other Party in writing under this Agreement. Any notice so sent is effective when received. 

 

			
	 Notices to: PCAS
  

PCAS, Inc.
 BP 181 - 23 Rue Bossuet, Z.I. La Vigne aux

Loups
 91160 Longjumeau - France

 
 With copy to:
		 Notices to: COLUCID
  

CoLucid Pharmaceuticals, Inc.
 P.O. Box 14401

Durham, NC 27709
  

or (for overnight courier only):
 [Home address redacted]

 
 Fax: 919-806-4301

Email: kkelly@colucid.com
 Contact Person: Kathy Kelly

 
 With copy to:
  

Faegre Baker Daniels
 Attention: Jennifer Kremp

600 East 96th Street, Suite 600

Indianapolis, IN 46240

  

	12.2	Enforceability. 

 If any provision or a portion of any provision of this Agreement is held to be
unenforceable or invalid by a court of competent or other competent authority, the validity and enforceability of the enforceable portion of any such provision and/or the remaining provisions of this Agreement will not be affected thereby and such
unenforceable provision shall be deemed to be deleted from this Agreement and the Parties shall substitute for any such unenforceable provision an enforceable provision that achieves to the greatest extent permissible the economic, legal and
commercial objectives of the unenforceable provision. 

  
 16 

	12.3	Waiver. 

 Failure or delay by either Party to exercise any right or remedy under this Agreement
shall not be deemed to be a waiver of that right or remedy, or prevent it from exercising that or any other right or remedy on that occasion or on any other occasion. 
  

	12.4	Entire Agreement and Amendments. 

 This Agreement and all appendices and exhibits attached
hereto in accordance herewith constitutes the entire agreement and understanding of the Parties relating to the subject matter of this Agreement and supersedes all prior oral or written agreements, representations, understandings or arrangements
between the Parties relating to the subject matter of this Agreement. No change may be made to this Agreement except in writing in the English language signed by the duly authorized representatives of both Parties. 

 

	12.5	Relationship of the Parties. 

 Each Party to this Agreement is an independent contractor and
nothing contained in this Agreement shall be construed to place the Parties in the relationship of employer and employee, partners, principal and agent, or joint venturers. Employees and agents of one Party are not employees or agents of the other
Party, shall not hold themselves out as such, and shall not have any authority or power to bind the other Party to any contract or other obligation. Neither Party shall act or describe itself as the agent of the other Party nor shall it represent
that it has any authority to make commitments on the other Party’s behalf. 
  

	12.6	Assignment. 

 Neither Party shall be entitled to assign this Agreement and/or the obligations of
this Agreement without the prior written consent of the other Party, with the sole exception that COLUCID may assign this Agreement in conjunction with the merger or sale of all or substantially all of the assets to which this Agreement relates
without the prior written consent of PCAS. 
  

	12.7	Subcontracting. 

 PCAS shall not subcontract any of its obligations under this Agreement or any
Work Order to any subcontractor unless approved in writing in advance by COLUCID. Where the Services or part thereof are subcontracted by PCAS with COLUCID’s consent, PCAS shall carry out such reconciliations, checks and testing as are
reasonable to verify the integrity of the work carried out by subcontractor and to verify that all materials including but not limited to the Compound, COLUCID Intellectual Property or other property of COLUCID provided by PCAS to such subcontractor
are handled by subcontractor in accordance with the terms of this Agreement. Notwithstanding COLUCID’s consent to use of such subcontractor, PCAS will be responsible to COLUCID for any portion of the performance of this Agreement by such
subcontractor to the same extent as if that performance was rendered directly by PCAS. 

  
 17 

	12.8	Publicity. 

 COLUCID and PCAS shall not make any announcement, or comment upon, or otherwise
provide any information to any third party (other than its legal and financial advisors) for promotional or any other purpose, concerning the existence of this Agreement, the terms thereof, or amendments thereto, the performance of this Agreement
and/or any dispute or disagreement relating to this Agreement without the prior written consent of PCAS or COLUCID respectively, except for disclosures required by law or stock exchange rules or to pursue legal resolution of a dispute hereunder.

  

	12.9	Prior Agreements. 

 The terms of this Agreement apply to the Services listed in the Proposal(s)
or other Work Orders attached to this Agreement in Appendix A (retroactively if applicable) and supersede any other prior agreements (oral or in writing) relating to the Proposal(s) or other Work Orders. 

 

	12.10	Governing Law and Jurisdiction. 

 The validity, construction and performance of this Agreement
shall be governed by the laws of the State of New York, without regard to its conflicts of law principles, and the laws of the United States. In the event of any controversy or claim arising out of or relating to any provision of this Agreement or
the breach thereof, the Parties will try to settle their differences amicably by themselves. Any such controversy or claim which the Parties are unable to resolve shall initially be submitted for review and resolution by the senior management of the
Parties. In case the senior management cannot come to an agreement within a reasonable time, any action, suit or other proceeding initiated by either Party hereto under or in connection with this Agreement may be brought in any Federal or state
court in the State of New York having jurisdiction over the subject matter thereof as the Party bringing such action, suit or proceeding shall elect. The Parties hereby submit themselves to the jurisdiction of any such court and agree that service
of process on them in any such action, suit or proceeding may be affected by the means by which notices are to be given to it under this Agreement. 
  

	12.11	Inspection. 

 PCAS will permit COLUCID’s representatives (unless such representatives are
competitors of PCAS) to examine or audit the work performed hereunder and the facilities at which the work is conducted, upon reasonable advance written notice, during regular business hours, solely to determine that the Services are being performed
in accordance with Specifications, the applicable Work Order and this Agreement. All Confidential Information of PCAS disclosed or ascertained by COLUCID in connection with any audit or examination will be kept confidential in accordance with
Section 4 of this Agreement, and COLUCID will not disclose to any third party or use such information for any purpose other than conducting the foresaid audit or examination under this Section 12.11 provided, however, that COLUCID may
disclose the information if required by law or court order. 

  
 18 

	12.12	Debarment Certification. 

 PCAS agrees that PCAS has not and will not use in any capacity in
connection with this Agreement the services of any person debarred under 21 USC 335(a)(a) or 21 USC 335(a)(b), (as amended) or under any similar laws of other countries. PCAS will require the same certification of its approved sub-contractors. In
the event that PCAS or any person or organization PCAS uses, contracts with or involves in connection with this Agreement should become debarred or disqualified (or actions are taken that threaten the same) during the course of performance of
Services under this Agreement, PCAS agrees to immediately notify COLUCID in writing. 
  

	12.13	Regulatory Authorities. 

 AT COLUCID’s request and expense, a representative of PCAS shall
accompany COLUCID to meet with representatives of applicable regulatory agencies (collectively, “Regulatory Authority”), to explain or discuss any and all aspects of Services provided under this Agreement. Such visits shall be arranged at
times mutually agreeable between COLUCID and PCAS. PCAS shall notify COLUCID of any request from Regulatory Authority, other federal or state agencies, or any third party to inspect or otherwise gain access to the records or other information
related to COLUCID projects done under this Agreement. PCAS shall notify COLUCID of such requests prior to permitting any third-party access unless prior notice is not possible. PCAS agrees to permit inspection of its facilities and records by
authorized representatives of the Regulatory Authority and as otherwise required by law. PCAS agrees to promptly notify COLUCID of any inspections or communications related to a Project by Regulatory Authorities and provide to COLUCID copies of such
communications and the findings of any such inspections. PCAS acknowledges and agrees that it shall not disclose any Confidential Information of COLUCID to any Regulatory Authority unless such information is specifically required to be disclosed by
such Regulatory Authority. 
  

	12.14	Insurance. 

 Each party shall maintain during the term of this Agreement and for at least five
(5) years after expiration of the last batch of Product manufactured by PCAS under this Agreement, policies of insurance in the amounts and of the types reasonably appropriate for the conduct of their respective businesses. Each Party shall
provide to the other Party upon request, certificates of insurance evidencing such coverage. 
  

	12.15	Set-Off. 

 Without limiting any party’s rights under law or in equity, either party may
exercise a right of set-off against any and all amounts in default and due hereunder from one party to the other. For purposes of this Section 12.15, PCAS and its subsidiaries, parent and other direct and indirect affiliates will be deemed to
be a single creditor. 

  
 19 

	12.16	Conflict of Interest. 

 During the term of this Agreement, PCAS shall not undertake to provide
materials or services for any third party to the extent that such provision of materials and services would hinder, delay or adversely impact PCAS’s ability to provide the products and Services requested by COLUCID under this Agreement. 

 

	12.17	Third Party Beneficiaries. 

 Nothing in this Agreement, whether express or implied, is intended
to confer any rights or remedies under or by reason of this Agreement on any persons other than the Parties hereto and their respective successors, assigns, and Affiliates. 
  

	12.18	Counterparts. 

 This Agreement may be executed in counterparts, each of which shall be deemed to
be an original and all of which together shall be deemed to be one and the same instrument. This Agreement may be delivered by one or both Parties by facsimile or electronic transmission with the same effect as if delivered personally. 

THE REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK 

  
 20 

 IN WITNESS WHEREOF, the Parties hereto have executed this Agreement through their duly authorized
representatives. 
  

			
	“PCAS”
	
	PCAS Group
		
	By:		 /s/ D. Combis

	Name:		 Didier Combis

	Title:		 Sr. Director B.U. Exclusive Synthesis

	
	“COLUCID”
	
	CoLucid Pharmaceuticals, Inc.
		
	By:		 /s/ Thomas P. Mathers

	Name:		 Thomas P. Mathers

	Title:		 CEO

  
 21

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