Document:

Consulting Agreement with Cynthia Kenyon

 Exhibit 10.15 
 CONSULTING AGREEMENT 
 THIS CONSULTING
AGREEMENT (the “Agreement”), made as of March 30, 2001 is entered into by Elixir Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and Cynthia Kenyon, Ph.D., residing at 4366 25th Street, San Francisco, CA 94114 (the “Consultant”). 
 INTRODUCTION 
 The Company desires to retain the services of the Consultant and the Consultant desires to perform certain
services for the Company. In consideration of the mutual covenants and promises contained herein and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged by the parties hereto, the parties agree as
follows: 
 1. Services. During the Consultation Period (as defined below), the Consultant agrees to devote up to, but not more than,
39 days per academic year, or 48 days per calendar year, to the performance of such consulting, advisory and related services to and for the Company as may be reasonably requested from time to time by the Company. The Consultant shall perform such
services at the offices of the Company or at such other location as is reasonably acceptable to both the Company and the Consultant. 
 2.
Term. This Agreement shall commence on the date hereof and shall continue until March 30, 2005 (such period, as it may be extended, being referred to as the “Consultation Period”), unless sooner terminated in accordance with
the provisions of Section 4. The provisions of Sections 6 and 7 hereof shall survive the expiration or termination of this Agreement. 
 3. Compensation. 
 3.1 Consulting Fees. 
 (a) 2001. For services rendered during 2001, the Company shall pay the Consultant as follows: 
 (i)
Prior to July 1, 2001. The Company shall pay to the Consultant consulting fees of $1.00 per month, payable in arrears on the last day of each month. 
 (ii) After July 1, 2001. The Company shall pay to the Consultant consulting fees of $6874.50 per month, payable in arrears on the last day of each month. 
 (b) Remainder of Consultation Period. The Company shall pay to the Consultant consulting fees of $4583.33 per month, payable in arrears on the
last day of each month. Payment for any partial month shall be prorated. 
 3.2 Reimbursement of Expenses. The Company shall reimburse
the Consultant for all reasonable expenses incurred or paid by the Consultant in connection with, or 

 
related to, the performance of his services under this Agreement. The Consultant shall submit to the Company itemized statements, in a form satisfactory to
the Company, of such expenses incurred by the Consultant. The Company shall pay to the Consultant the amounts shown on each such statement within 30 days after receipt thereof. 
 3.3 Benefits. The Consultant shall not be entitled to any benefits, coverages or privileges, including, without limitation, social security,
unemployment, medical or pension payments, made available to employees of the Company. 
 4. Termination. Consultant may, without
prejudice to any right or remedy he/she may have due to any failure of the Company to perform its obligations under this Agreement, terminate the Consultation Period upon 30 days’ prior written notice to the Company. In the event of such
termination, the Consultant shall be entitled to payment for services performed and expenses paid or incurred prior to the effective date of termination, subject to the limitation on reimbursement of expenses set forth in Section 3.2. The
Company may terminate the Consultation Period upon thirty (30) day’s prior written notice to Consultant only for Cause (as hereinafter defined). As used herein, “Cause” shall mean misconduct, including: (1) conviction of any
felony involving moral turpitude or dishonesty; (2) participation in a fraud or act of dishonesty against the Company; (3) willful and material breach of Section 6 or Section 7 of this Agreement; or (4) intentional and
material damage to the Company’s property. 
 5. Cooperation. The Consultant shall use his best efforts in the performance of his
obligations under this Agreement. The Company shall provide such access to its information and property as may be reasonably required in order to permit the Consultant to perform his obligations hereunder. The Consultant shall cooperate with the
Company’s personnel, shall not interfere with the conduct of the Company’s business and shall observe all rules, regulations and security requirements of the Company concerning the safety of persons and property. 
 6. Non-Disclosure and Developments. 
 6.1 Proprietary Information. 
 (a) The Consultant agrees that all information, whether or not in writing, of a private,
secret or confidential nature concerning the Company’s business, business relationships or financial affairs (collectively, “Proprietary Information”) is and shall be the exclusive property of the Company. By way of illustration, but
not limitation, Proprietary Information may include inventions, products, processes, methods, techniques, formulas, compositions, compounds, projects, developments, plans, research data, clinical data, financial data, personnel data, computer
programs, customer and supplier lists, and contacts at or knowledge of customers or prospective customers of the Company. The Consultant will not disclose any Proprietary Information to any person or entity other than employees or consultants of the
Company or use the same for any purposes (other than in the performance of his duties as a Consultant of the Company) without written approval by an officer of the Company, either during the Consulting Period or after the Consultation Period, unless
and until such Proprietary Information has become public knowledge without fault by the Consultant. Notwithstanding the other provisions of this Agreement, nothing received by Consultant will be considered to be Proprietary Information if
(1) it has been published or is otherwise readily available to the public 

  

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other than by a breach of this Agreement; (2) it has been rightfully received by Consultant from a third party without confidential limitations
(3) it was independently developed by Consultant; or (4) it was known to Consultant prior to its first receipt from the Company. 
 (b) The Consultant agrees that all files, letters, memoranda, reports, records, data, sketches, drawings, laboratory notebooks, program listings, or other written, photographic, or other tangible material containing Proprietary Information,
whether created by the Consultant or others, which shall come into his custody or possession, shall be and are the exclusive property of the Company to be used by the Consultant only in the performance of his duties for the Company. All such
materials or copies thereof and all tangible property of the Company in the custody or possession of the Consultant shall be delivered to the Company, upon the earlier of (i) a request by the Company or (ii) termination of the Consultation
Period. After such delivery, the Consultant shall not retain any such materials or copies thereof or any such tangible property other than one copy of such materials that the Consultant may retain for his/her own records. 
 (c) The Consultant agrees that his/her obligation not to disclose or to use information and materials of the types set forth in paragraphs (a) and
(b) above, and his obligation to return materials and tangible property, set forth in paragraph (b) above, also extends to such types of information, materials and tangible property of customers of the Company or suppliers to the Company
or other third parties who may have disclosed or entrusted the same to the Company or to the Consultant. 
 6.2 Developments.

 (a) The Consultant will make full and prompt disclosure to the Company of all inventions, improvements, discoveries, methods,
developments, software, and works of authorship, whether patentable or not, which are created, made, conceived or reduced to practice by him/her in connection with the performance of the Consultants duties under this Agreement during the
Consultation Period in the field of aging, whether or not during normal working hours or on the premises of the Company (all of which are collectively referred to in this Agreement as “Developments”). The Company is informed that
Consultant has signed a patent agreement with The Regents of the University of California and, under that Agreement, Consultant has agreed to report any inventions conceived of or made during the term of Consultant’s University of California
employment, and to assign certain of such inventions to The Regents in accordance with the terms of its Patent Policy. Nothing in this Consulting Agreement shall be construed to interfere with these obligations to The Regents. 
 (b) The Consultant agrees to assign and does hereby assign to the Company (or any person or entity designated by the Company) all his right, title and
interest in and to all Developments and all related patents, patent applications, copyrights and copyright applications. However, this paragraph 2(b) shall not apply to Developments which do not relate to the present business or research and
development of the Company and which are made and conceived by the Consultant not during normal working hours, not on the Company’s premises and not using the Company’s tools, devices, equipment or Proprietary Information. The Consultant
understands that, to the extent this Agreement shall be construed in accordance with the laws of any state which precludes a requirement in an employee agreement to assign certain 

  

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classes of inventions made by an employee, this paragraph 2(b) shall be interpreted not to apply to any invention which a court rules and/or the Company
agrees falls within such classes. The Consultant also hereby waives all claims to moral rights in any Developments. 
 (c) The Consultant
agrees to cooperate fully with the Company, both during and after the Consultation Period, with respect to the procurement, maintenance and enforcement of copyrights, patents and other intellectual property rights (both in the United States and
foreign countries) relating to Developments. The Company agrees to provide payment on a reasonable per diem basis for post Consulting Period cooperation efforts (as provided for in the previous sentence), which require more than trivial effort on
the part of the Consultant. The Consultant shall sign all papers, including, without limitation, copyright applications, patent applications, declarations, oaths, formal assignments, assignments of priority rights, and powers of attorney, which the
Company may deem necessary or desirable in order to protect its rights and interests in any Development. The Consultant further agrees that if the Company is unable, after reasonable effort, to secure the signature of the Consultant on any such
papers, any executive officer of the Company shall be entitled to execute any such papers as the agent and the attorney-in-fact of the Consultant, and the Consultant hereby irrevocably designates and appoints each executive officer of the Company as
his agent and attorney-in-fact to execute any such papers on his behalf, and to take any and all actions as the Company may deem necessary or desirable in order to protect its rights and interests in any Development, under the conditions described
in this sentence. 
 6.3 Other Agreements. The Consultant represents that his performance of all the terms of this Agreement and the
performance of his duties as a consultant of the Company do not and will not breach any agreement with any prior employer or other party to which the Consultant is a party (including without limitation any nondisclosure or non-competition
agreement), and that the Consultant will not disclose to the Company or induce the Company to use any confidential or proprietary information or material belonging to any previous employer or others. 
 6.4 United States Government Obligations. 
 The Consultant acknowledges that the Company from time to time may have agreements with other persons or with the United States Government, or agencies thereof, which impose obligations or restrictions on the Company regarding inventions
made during the course of work under such agreements or regarding the confidential nature of such work. The Consultant agrees to be bound by all such obligations and restrictions which are made known to the Consultant and to make a good faith effort
to discharge the obligations of the Company under such agreements. 
 7. Non-Competition and Non-Solicitation. During the Consultation
Period and for a period of eighteen (18) months after the termination or cessation of such period for any reason, the Consultant will not directly or indirectly: 
 7.1 Engage in any business or enterprise (whether as owner, partner, officer, director, employee, consultant, investor, lender or otherwise, except as the holder of not more than 1% of the outstanding stock of a
publicly-held company) that develops, manufactures, sells or provides any product or service that competes with any product or service developed, manufactured, marketed, sold or provided by, or under development by, the Company during the
Consultation Period; or 
  

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 7.2 Either alone or in association with others (i) solicit, or permit any organization directly or
indirectly controlled by the Consultant to solicit, any employee of the Company to leave the employ of the Company, or (ii) solicit for employment, or permit any organization directly or indirectly controlled by the Consultant to solicit for
employment, any person who was employed by the Company at any time during the term of or at the time of the termination or cessation of the Consultation Period; provided, that this clause (ii) shall not apply to any individual
whose employment with the Company has been terminated for a period of six months or longer. 
 Notwithstanding the foregoing,
Section 7.1 shall not preclude the Consultant from becoming an employee of, or from otherwise providing services to, a separate division or operating unit of a multi-divisional business or enterprise (a “Division”) if: (i) the
Division by which the Consultant is employed, or to which the Consultant provides services, is not competitive with the Company’s business (within the meaning of Section 7.1), (ii) the Consultant does not provide services, directly or
indirectly, to any other division or operating unit of such multi-divisional business or enterprise which is competitive with the Company’s business (within the meaning of Section 7.1) (individually, a “Competitive Division” and
collectively, the “Competitive Divisions”) and (iii) the Competitive Divisions, in the aggregate, accounted for less than one-third of the multi-divisional business or enterprises’ consolidated revenues for the fiscal year, and
each subsequent quarterly period, prior to the Consultant’s commencement of employment with the Division. 
 8. Remedies. The
Consultant acknowledges and agrees that the agreements and restrictions contained in Sections 6 and 7 are necessary for the protection of the business and goodwill of the Company and are reasonable for such purpose. The Consultant acknowledges that
any breach of the provisions of this Sections 6 and 7 may result in serious and irreparable injury to the Company for which the Company cannot be adequately compensated by monetary damages alone. The Consultant agrees, therefore, that, in addition
to any other remedy it may have, the Company shall be entitled to enforce the specific performance of this Agreement by the Consultant and to seek both temporary and permanent injunctive relief (to the extent permitted by law) without the necessity
of proving actual damages. 
 9. Independent Contractor Status. The Consultant shall perform all services under this Agreement as an
“independent contractor” and not as an employee or agent of the Company. Neither party is authorized to assume or create any obligation or responsibility, express or implied, on behalf of, or in the name of, the other or to bind the other
in any manner. 
 10. Notices. All notices required or permitted under this Agreement shall be in writing and shall be deemed
effective upon personal delivery or upon deposit in the United States Post Office, by registered or certified mail, postage prepaid, addressed to the other party at the address shown above, or at such other address or addresses as either party shall
designate to the other in accordance with this Section 10. 
  

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 11. Pronouns. Whenever the context may require, any pronouns used in this Agreement shall include
the corresponding masculine, feminine or neuter forms, and the singular forms of nouns and pronouns shall include the plural, and vice versa. 
 12. Entire Agreement. This Agreement constitutes the entire agreement between the parties and supersedes all prior agreements and understandings, whether written or oral, relating to the subject matter of this Agreement. 

13. Amendment. This Agreement may be amended or modified only by a written instrument executed by both the Company and the Consultant.

 14. Governing Law. This Agreement shall be construed, interpreted and enforced in accordance with the laws of the Commonwealth of
Massachusetts. 
 15. Successors and Assigns. This Agreement shall be binding upon, and inure to the benefit of, both parties and
their respective successors and assigns, including any corporation with which, or into which, the Company may be merged or which may succeed to its assets or business, provided, however, that the obligations of the Consultant are personal and shall
not be assigned by him. 
 16. Miscellaneous. 
 16.1 No delay or omission by either party in exercising any right under this Agreement shall operate as a waiver of that or any other right. A waiver or consent given by a party on any one occasion shall be effective
only in that instance and shall not be construed as a bar or waiver of any right on any other occasion. 
 16.2 The captions of the sections
of this Agreement are for convenience of reference only and in no way define, limit or affect the scope or substance of any section of this Agreement. 
 16.3 In the event that any provision of this Agreement shall be invalid, illegal or otherwise unenforceable, the validity, legality and enforceability of the remaining provisions shall in no way be affected or
impaired thereby. 
 16.4 The Consultant represents that it has the competence required to perform in a professional manner the services
contemplated herein. The Company understands and acknowledges that the Consultant has made no express or implied warranties. 
 16.5 The
Company agrees to cooperate with the Consultant on all reasonable requests made by the Consultant including, without limitation, allowing the Consultant reasonable access to the Company’s place of business, staff members, books and records to
permit the Consultant to perform its services as fully and economically as possible. The Consultant may not be held liable for non-performance where the Consultant is unable to perform, or performance is delayed, due to circumstances beyond the
Consultant’s control including those caused by the Company. 
  

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 16.6 With regard to the services to be performed by the Consultant pursuant to the terms of this
Agreement, the Consultant shall not be liable to the Company, or to anyone who may claim any right due to his relationship with the Company, for any acts or omissions in the performance of said services on the part of the consultant or on the part
of the agents or employees or contractors of the consultant, except when said acts or omissions of the Consultant are due to their willful misconduct. The Company shall hold the consultant and its agents, employees, or contractors (each an
“indemnified person”) free and harmless from any obligations, costs, claims, judgments, attorney fees and disbursements, and attachments arising from or growing out of the services rendered to the Company pursuant to the terms of this
Agreement or in any way connected with the rendering of said services, except when the same shall arise solely due to the willful misconduct of the indemnified person as finally judicially determined by a court of competent jurisdiction. The Company
agrees that the indemnification and reimbursement commitment set forth in this Agreement shall apply whether or not the indemnified person is a formal party to any such lawsuits or other proceeding, that the indemnified person is entitled to retain
separate counsel of its choice in connection with any of the matter to which such indemnification relates and such indemnification shall survive any termination of this Agreement. The Company shall advance to Consultant any indemnifiable costs in
connection with any action which the Consultant was or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or investigative, by reason of the fact that he/she
is or was a consultant. Such advances and reimbursements shall be paid to the Consultant promptly following request therefor. The Company further agrees that it will not, without the prior written consent of the indemnified person, settle,
compromise or consent to the entry of any judgment in any pending or threatened claim in respect of which indemnification may be sought hereunder (whether or not the indemnified person is an actual or potential party to such claim), if such
settlement, compromise or consent includes any injunctive relief against the indemnified person. 
 [Remainder of this page is left blank
intentionally.] 
  

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 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year set forth
above. 
  

			
	ELIXIR PHARMACEUTICALS, INC.
	
	 /s/ Cindy Bayley

	By:	 	Cindy Bayley
	Title:	 	President
	
	CONSULTANT
	
	 /s/ Cynthia Kenyon

	Cynthia Kenyon

  

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	 	 February 22, 2005
  
 Dr. Cynthia Kenyon
 55 Los Pinos Spur
 Nicasio, CA 94946-9759

	 
	 
	 

 Dear Cynthia: 
 As you may have noted, your CONSULTING AGREEMENT with Elixir Pharmaceuticals, Inc., dated March 30, 2001, will expire on March 30, 2005. As discussed verbally, we wish to extend the agreement for an
additional year, ending March 30, 2006. In addition, this notice will amend Section 3. Compensation to read as follows: 
  

	 	3.1	Consulting Fees. The Company shall pay to the Consultant consulting fees of $5,583.33 per month, payable in advance on the first day of each month. Payment for any partial
month shall be prorated. 

  

	 	3.2	Reimbursement of Expenses. The Company shall reimburse the Consultant for all reasonable expenses incurred or paid by the Consultant in connection with, or related to, the
performance of her service under this Agreement. All Company related travel arrangements will be made in accordance with the Company travel policy in effect at the time travel arrangements are booked. The Consultant shall submit to the Company
itemized statements, in a form satisfactory to the Company, of such expenses incurred by the Consultant. The Company shall reimburse the Consultant for all amounts incurred or paid by the Consultant, in compliance with the Company travel policy
within 30 days after receipt thereof. 

  

	 	3.3	Benefits. The Consultant shall not be entitled to any benefits, coverages or privileges, including, without limitation, social security, unemployment, medical or pension
payments, made available to employees of the Company. 

 Please sign and return one copy of this notice and keep the other for
your records as an amendment to the CONSULTING AGREEMENT, dated March 30. 2001. 
  

									
		 	Sincerely,	 		 		 	
					
		 	 /s/ William K. Heiden
	 		 		 	
		 	William K. Heiden	 		 		 	
		 	President and CEO	 		 		 	
					
		 		 		 	Signed:	 	 /s/ Cynthia Kenyon

		 		 		 		 	Dr. Cynthia Kenyon
					
		 		 		 	Date:	 	Mar 7, 2005
					
		 	Elixir Pharmaceuticals, Inc.	 	One Kendall Square	 		 	Tel 617.995.7000
		 	www.elixirpharm.com	 	Building 1000, Fifth Floor	 		 	Fax 617.995.7050
		 		 	Cambridge. MA 02139	 		 	

 CONFIDENTIAL DRAFT 
 March 28, 2006 
 Dr. Cynthia Kenyon 
 55 Los Pinos Spur 
 Nicasio, CA 94946

 Dear Cynthia: 
 Your
CONSULTING AGREEMENT with Elixir Pharmaceuticals, Inc., dated March 30, 2001 and extended by Letter Agreements dated February 22, 2005, will expire on March 30, 2006. As we discussed, Elixir wishes to extend the agreement for an
additional six (6) months, to September 30, 2006. In addition, we have agreed to amend the length of the non-compete portion of your agreement, specifically Section 7. Non-Competition and Non-Solicitation as follows:

  

	 	7.	Non-Competition and Non-Solicitation. During the Consultation Period and for a period of twelve (12) months after the termination or cessation of such period for
any reason, the Consultant will not directly or indirectly... 

 Unless otherwise amended above or in the previous Letter
Amendment all terms and conditions of the CONSULTING AGREEMENT shall continue and remain in force until September 30, 2006. 
 Please
sign and return one copy of this notice and keep the other for your records as a letter amendment to the CONSULTING AGREEMENT dated March 30, 2001. 
  

									
		 	Sincerely,	 		 		 	
					
		 	William K. Heiden	 		 		 	
		 	President and CEO	 		 		 	
					
		 		 		 	Signed:	 	 /s/ Cynthia Kenyon

		 		 		 		 	Dr. Cynthia Kenyon
					
		 		 		 	Date:	 	Mar 30, 2006

 

 
  

			
	

	 	October 20, 2006
	 	  
 Dr. Cynthia Kenyon

	 	55 Los Pinos Spur
	 	Nicasio, CA 94946

 Dear Cynthia: 
 Your CONSULTING AGREEMENT with Elixir Pharmaceuticals, Inc. dated March 30, 2001 and extended by Letter Agreements dated February 22, 2005 and March 28, 2006 will expire on September 30, 2006. As
we discussed, Elixir wishes to extend the agreement for an additional twelve (12) months to September 30, 2007. 
 Unless otherwise
amended according to the previous Letter Amendments all terms and conditions of the CONSULTING AGREEMENT shall continue and remain in force until September 30, 2007. 
 Please sign and return one copy of this notice and keep the other for your records as a second Letter Amendment to the CONSULTING AGREEMENT dated March 30, 2001. 
  

									
		 	Sincerely,	 		 		 	
					
		 	 /s/ William K. Heiden
	 		 		 	
		 	William K. Heiden	 		 		 	
		 	President and CEO	 		 		 	
					
		 		 		 	Signed:	 	 /s/ Cynthia Kenyon

		 		 		 		 	Dr. Cynthia Kenyon
					
		 		 		 	Date:	 	Nov 1, 2006
					
		 	Elixir Pharmaceuticals, Inc.	 	One Kendall Square	 		 	Tel 617.995.7000
		 	www.elixirpharm.com	 	Building 1000, Fifth Floor	 		 	Fax 617.995.7050
		 		 	Cambridge, MA 02139Consultant Agreement with Vaughn Kailian

 Exhibit 10.16 
 CONSULTANT AGREEMENT 
 THIS CONSULTANT AGREEMENT (“Agreement”) dated as of
January 30, 2004, is made between Elixir Pharmaceuticals, Inc. (the “Company”), with an office at One Kendall Square, Building 1000, Fifth Floor, Cambridge, MA 02139, and Vaughn Kailian (the “Consultant”), with
an office at Deerhaven Partners, P.O. Box 70,1100 Fitzpatrick Lane, Bodega, CA 94922, for the purpose of setting forth the exclusive terms and conditions by which Company desires to acquire Consultant’s services on a temporary basis.

 In consideration of the mutual obligations specified in this Agreement, the parties, intending to be legally bound hereby, agree to the
following: 
 1. Services. Effective as of the date hereof, the Company hereby retains Consultant, and Consultant hereby agrees
to perform for Company, certain services assigned to Consultant by the Company, as agreed to from time to time by Consultant and the Board of Directors of the Company (the “Services”). 
 2. Compensation. 
 (a) In
exchange for the Services to be rendered to Company hereunder, Company shall provide Consultant, as full and complete compensation for the Services rendered hereunder, the amount of $ 16,667 per month. Should Consultant continue to perform the
Services beyond October 1, 2004, such payments shall be reduced to $8,333 per month. In addition, subject to the approval of the Company’s Board of Directors, Consultant shall receive a grant of non-statutory stock options to purchase
320,000 shares of the Company’s common stock at an exercise price of $0.10 per share. Such options shall have a term of 10 years, and shall vest over 4 years, with 25% of such options to be fully vested as of January 30, 2004, and the
remaining options vesting ratably over 36 months commencing on January 30, 2005. Such options shall also have an early exercise feature, and other terms as set forth by a non-statutory stock option agreement in accordance with the
Company’s 2001 Stock Incentive Plan, which shall govern such option grant. 
 (b) Consultant shall be entitled to reimbursement from
Company for all reasonable approved business expenses he incurs in connection with his performance of the Services, pursuant to Company’s regular business practices for consultants. 
 (c) Consultant shall not be entitled to receive any other compensation or any benefits from Company. Except as otherwise required by law, Company shall
not withhold any sums or payments made to Consultant for social security or other federal, state or local tax liabilities or contributions, and all withholdings, liabilities, and contributions shall be solely Consultant’s responsibility.
Company shall issue a Form 1099 to Consultant at the appropriate time. Further, Consultant understands and agrees that the Services are not covered under the unemployment compensation laws and not intended to be covered by workers’ compensation
laws. 
 3. Nondisclosure. 
 (a) Consultant understands that, in connection with his engagement with Company, he may receive, produce, or otherwise be exposed to Company’s trade secrets, business, 

  

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proprietary and/or technical information, including, without limitation, business plans or projections, hardware and software designs or engineering
techniques, software including listings, source code, screen formats and flow charts, inventions (whether patentable or not), know-how, show-how, research plans and projects, pricing policies, cost information, supplier and customer lists and
contracts, manufacturing techniques, applications and service policies, financial and sales performance data, personnel information, and all derivatives, improvements and enhancements to any of the above (including those derivatives, improvements
and enhancements that were created or developed by Consultant under this Agreement), in addition to all information Company receives from others under an obligation of confidentiality (individually and collectively “Confidential
Information”). Confidential Information also shall include all other information considered to be confidential by the Company and all Company information which has not been made public. 
 (b) Consultant acknowledges that the Confidential Information is the sole, exclusive and extremely valuable property of Company. Accordingly, Consultant
agrees to segregate all Confidential Information from information of other companies; agrees to only use the Confidential Information in the performance of this Agreement; and agrees not to reproduce or divulge to any third party, all or any part of
the Confidential Information, in any form, either during or after the term of this Agreement, without Company’s prior written consent. Upon termination or expiration of this Agreement for any reason, Consultant agrees to cease using and to
return to Company all whole and partial copies and derivatives of the Confidential Information, whether in Consultant’s possession or under Consultant’s direct or indirect control. 
 (c) Consultant shall not disclose or otherwise make available to Company in any manner any confidential and proprietary information received by
Consultant from third parties. Consultant warrants that his performance of all the terms of this Agreement does not and will not breach any agreement entered into by Consultant with any other party, and Consultant agrees not to enter into any
agreement, oral or written, in conflict herewith. In addition, Consultant recognizes that the Company has received and in the future will receive from third parties their confidential or proprietary information subject to a duty on the
Company’s part to maintain the confidentiality of such information and to use such information only for certain limited purposes. Consultant agrees that he owes the Company and such third parties, during the term of the Consultant’s
relationship with the Company and thereafter, regardless for the reason for the termination of the relationship, a duty to hold all such confidential or proprietary information in the strictest of confidence and not to disclose such information to
any person, firm or corporation (except as necessary in carrying out his work for the Company consistent with the Company’s agreement with such third party) or to use such information for the benefit of anyone other than for the Company or such
third party (consistent with the Company’s agreement with such third party). 
 (d) Consultant also agrees that during this relationship
with Company he shall not make, use or permit to be used any Company Property otherwise than for Company’s benefit. The term “Company Property” shall include all notes, memoranda, reports, lists, records, drawings, sketches, designs,
specifications, software programs, software code, data, computers, cellular telephones, pagers, credit and/or calling cards, keys, access cards, documentation or other materials of any nature and in any form, whether written, printed, electronic or
in digital format or otherwise, relating to any matter within the Company’s scope of the business or 

  

 2. 

 
concerning any of its dealings or affairs and any other Company property in his possession, custody or control. Consultant further agrees that he shall not,
after the termination or expiration of this Agreement, use or permit others to use any such Company Property. Consultant acknowledges and agrees that all Company Property shall be and remain Company’s sole and exclusive property. Immediately
upon the termination or expiration of this Agreement, Consultant shall deliver all Company Property in its possession, and all copies thereof, to Company. 
 4. Ownership of Work Product. Consultant agrees to promptly disclose to Company any and all Work Product. “Work Product” includes without limitation any and all notes, drawings, designs,
technical data, know how, works of authorship, firmware, software, ideas, improvements, inventions, material, information, work or product authored, conceived, created, discovered, invented, written or first reduced to practice by Consultant or
jointly with others that (a) relates to the business of the Company or any of the products or services being developed, manufactured or sold by the Company or which may be used in relation therewith and results from tasks assigned to Consultant
by the Company or performed by Consultant on behalf of the Company or in his role as a member of the Company’s Board of Directors, or (c) results from Consultant’s use of the premises or personal property (whether tangible or
intangible) owned, leased or contracted for by the Company. All Work Product shall be considered works made for hire by Consultant for Company, and all Work Product shall be the sole and exclusive property of Company. To the extent any Work Product
is not already property of the Company, Consultant agrees to assign and does hereby assign to Company all right, title and interest, including without limitation any copyright, patent, trade secret, trademark (including the goodwill associated
therewith), moral rights, or other intellectual property rights in and to the Work Product. Upon expiration or termination for any reason of this Agreement, Consultant agrees to and shall provide Company with all Work Product generated under this
Agreement. 
 5. Indemnification. Consultant agrees to indemnify and hold Company harmless from and against any and all
claims, demands, liabilities, damages, costs, or expenses (including without limitation attorney’s fees, liquidated damages, penalties or interest) resulting from Consultant’s failure to pay any and all federal or state taxes required to
be withheld from or paid by employees, including, without limitation, and any and all income tax, social security, and F.U.T.A. taxes. 
 6. Independent Contractor. 
 (a) Company and Consultant expressly agree and understand that Consultant is an
independent contractor and nothing in this Agreement nor the services rendered hereunder is meant, or shall be construed in any way or manner, to create between them a relationship of employer and employee, principal and agent, partners or any other
relationship other than that of independent parties contracting with each other solely for the purpose of carrying out the provisions of the Agreement. Accordingly, Consultant acknowledges and agrees that Consultant shall not be entitled to any
benefits provided by the Company to its employees. In addition, Consultant shall have sole and exclusive responsibility for the payment of all federal, state and local income taxes, for all employment and disability insurance and for Social Security
and other similar taxes with respect to any compensation provided by the Company hereunder. Consultant shall assume and accept all responsibilities that are imposed on independent contractors by any applicable statute, regulation, rule of law, or
otherwise. 
  

 3. 

 (b) While Company is entitled to provide Consultant with general guidance to assist Consultant in
completing the scope of work to Company’s satisfaction, Consultant is ultimately responsible for directing and controlling the performance of the task and the scope of work, in accordance with the terms and conditions of this Agreement.
Consultant shall use its best efforts, energy and skill in its own name and in such manner as he sees fit. 
 7.
Termination. 
 (a) This Agreement and Consultant’s relationship with the Company hereunder may be terminated by either
party at any time, with or without Cause (as defined below) or prior notice. In the event of any such termination, Consultant shall, upon request, perform such work as may be requested to transfer work in process to the Company or to a party
designated by the Company. The parties further agree that any termination of this Agreement will not release nor discharge Consultant from his obligations as specified in Sections 3,4, 5, 6, 7 or 8. 
 (b) In the event either (i) Company terminates this Agreement without Cause, or (ii) there is a Change of Control (as defined below), Company
will accelerate by 12 months, as of the Agreement termination date, the vesting of Consultant’s stock options granted hereunder and any and all future Company stock option grants to Consultant. 
 As used in this Agreement, “Cause” shall mean Consultant’s (A) gross negligence, insubordination, dishonesty, fraud, embezzlement,
disregard of Company’s rules and policies or willful misconduct with regard to Company; (B) failure to perform Services reasonably requested by Company hereunder; (C) material breach of any agreement (including this Agreement) with
the Company to the extent such breach, if capable of cure, remains uncured 10 days after Consultant’s receipt of written notice thereof from Company, or (D) commission of any crime that constitutes a felony or a crime of moral turpitude

 As used in this Agreement, “Change of Control” shall mean: (A) any merger, consolidation or sale of, or investment in,
Company pursuant to an agreement to which Company is a party, immediately after which transaction Company’s shareholders immediately prior to the transaction cease to own at least 50% of the surviving entity (or parent entity), or (B) a
sale or exclusive license of all or substantially all of Company’s assets, in a single transaction or series of related transactions. 
 8. General. 
 (a) This Agreement may not be changed unless mutually agreed upon in writing by both Consultant
and Company. Sections 3, 4, 5, 6, 7 and 8 shall survive the termination of this Agreement regardless of the manner of such termination. Any waiver by Company of a breach of any provision of this Agreement shall not operate or be construed as a
waiver of any subsequent breach of such provision or any other provision hereof. 
 (b) Consultant hereby agrees that each provision herein
shall be treated as a separate and independent clause, and the unenforceability of any one clause shall in no way impair the 

  

 4. 

 
enforceability of any of the other clauses herein. Moreover, if one or more of the provisions contained in this Agreement shall for any reason be held to be
excessively broad as to scope, activity, subject or otherwise so as to be unenforceable at law, such provision or provisions shall be construed by the appropriate judicial body by limiting or reducing it or them, so as to be enforceable to the
maximum extent compatible with the applicable law as it shall then appear. 
 (c) Company shall have the right to assign this Agreement to
its successors and assigns and this Agreement shall inure to the benefit of and be enforceable by said successors or assigns. Consultant may not assign this Agreement or any rights or obligations hereunder without the prior written consent of
Company and this Agreement shall be binding upon Consultant’s heirs, executors, administrators and legal representatives. This Agreement and all aspects of the relationship between the parties hereto shall be construed and enforced in
accordance with and governed by the internal laws of the Commonwealth of Massachusetts without regard to its conflict of laws provisions. Moreover, Consultant hereby irrevocably submits to the exclusive jurisdiction of the state or federal courts of
the Commonwealth of Massachusetts for the purpose of any claim or action arising out of or based upon this Agreement and agrees not to commence any such claim or action other than in the above-named courts. 
 (d) This Agreement contains the entire agreement between the parties hereto with respect to the transactions contemplated herein. All other negotiations
and agreements (written or oral) between the parties are superseded by this Agreement and there are no representations, warranties, understandings or agreements other than those expressly set forth herein. The language of all parts of this Agreement
will in all cases be construed as a whole in accordance with its fair meaning and not strictly for or against either party hereto. 
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 5. 

 IN WITNESS WHEREOF, the parties hereto have executed this Consultant Agreement as a sealed instrument as
of the date first written above. 
  

									
		 	Consultant:	 		 	Elixir Pharmaceuticals, Inc.:
					
		 	 /s/ Vaughn Kailin
	 		 	By:	 	 /s/ Karen L. Roberts

		 	Vaughn Kailian	 		 	Title:	 	VP Finance & Admin

  

 6.

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