Document:

Securities Purchase Agreement

 Exhibit 4.02 
 SECURITIES PURCHASE AGREEMENT 
 This
SECURITIES PURCHASE AGREEMENT (this “Agreement”) is made and entered into as of February 24, 2012, by and between Amyris, Inc., a Delaware corporation (the “Company”), and the individuals or entities listed on
Schedule I hereto (each, a “Purchaser,” and collectively, the “Purchasers”). 

Preliminary Statement 
 The Purchasers desire to purchase, and the Company desires to offer and sell to the Purchasers, $25,000,000 in principal amount of its Convertible Senior Notes due 2017 (the
“Securities”). The Securities will be evidenced by Convertible Notes in the form attached hereto as Exhibit A. The Securities will be convertible into shares (the “Underlying Securities”) of the
Company’s common stock, $0.0001 par value per share (the “Common Stock”), in accordance with the terms of the Securities. 
 Agreement 
 The parties, intending to be
legally bound, agree as follows: 
 ARTICLE 1 
 SALE OF SECURITIES 
 Each Purchaser will
purchase from the Company a Security in the principal amount set forth next to such Purchaser’s name on Schedule I hereto. The total purchase price payable by each Purchaser for the Securities that such Purchaser is hereby agreeing to
purchase is set forth next to such Purchaser’s name on Schedule I hereto (the “Total Purchase Price”). The sale and purchase of the Securities to each Purchaser shall constitute a separate sale and purchase hereunder.

 ARTICLE 2 
 CLOSING; DELIVERY 
 2.1. Closing. The closing
(“Closing”) of the purchase and sale of the Securities to the Purchasers hereunder shall be held at the offices of Fenwick & West LLP, 801 California Street, Mountain View, California 94041 within one business day following
the date on which the last of the conditions set forth in Articles 6 and 7 have been satisfied or waived in accordance with this Agreement but in no event later than March 2, 2012 (such date, the “Closing Date”), or at
such other time and place as the Company and the Purchasers mutually agree upon. 
 2.2. Delivery. Prior
to the Closing, the Company shall execute and deliver to each Purchaser’s respective custodian, as indicated on Schedule I hereto under the column “Nominee Name” (each such custodian, a “Custodian”), the
applicable Purchaser’s Security in the name of the Custodian (which such Purchaser shall return to the Company if the Closing has not occurred by March 2, 2012 and such Security was so delivered to such Custodian). At the Closing, the
Company shall execute and deliver to the Purchasers the Registration Rights Agreement in the form attached hereto as Exhibit B (“Rights Agreement”) and the other documents referenced in Article 6 (other than the
Security which 

 
shall be delivered to the applicable Custodian). At the Closing, each Purchaser shall (i) execute and deliver to the Company the Rights Agreement, and (ii) pay the applicable Total
Purchase Price as set forth on Schedule I hereto to the Company by wire transfer of immediately available funds to such account or accounts as the Company shall designate in writing to such Purchaser at least two days prior to the Closing
Date. 
 ARTICLE 3 
 REPRESENTATIONS AND WARRANTIES OF THE COMPANY 
 The Company
represents, warrants and covenants to each Purchaser as follows: 
 3.1. Organization and Standing. The
Company and each of its subsidiaries is duly incorporated, validly existing, and in good standing under the laws of the jurisdiction of its organization. Each of the Company and its subsidiaries has all requisite power and authority to own and
operate its respective properties and assets and to carry on its respective business as presently conducted and as proposed to be conducted. The Company and each of its subsidiaries is qualified to do business as a foreign entity in every
jurisdiction in which the failure to be so qualified would have, or would reasonably be expected to have, a material adverse effect, individually or in the aggregate, upon the business, properties, tangible and intangible assets, liabilities,
operations, prospects, financial condition or results of operation of the Company and its subsidiaries or the ability of the Company or any of its subsidiaries to perform their respective obligations under the Transaction Agreements (as defined
below) (a “Material Adverse Effect”). 
 3.2. Subsidiaries. As used in this Agreement,
references to any “subsidiary” of a specified person shall refer to an affiliate controlled by such person directly, or indirectly through one or more intermediaries, as such terms are used in and construed under Rule 405 under the
Securities Act (which, for the avoidance of doubt, shall include the Company’s controlled joint ventures, including shared-controlled joint ventures). The Company’s subsidiaries are listed on Exhibit 21.01 to the Company’s Annual
Report on Form 10-K for the year ended December 31, 2010 and, except as Previously Disclosed (as defined in Section 3.9) are the only subsidiaries, direct or indirect, of the Company. All the issued and outstanding shares of each
subsidiary’s capital stock have been duly authorized and validly issued, are fully paid and nonassessable, have been issued in compliance with all federal and state securities laws, were not issued in violation of or subject to any preemptive
rights or other rights to subscribe for or purchase securities, and, except as Previously Disclosed, are owned by the Company or a Company subsidiary free and clear of all liens, encumbrances and equities and claims. 

3.3. Power. The Company has all requisite power to execute and deliver this Agreement, to sell and issue the
Securities hereunder, and to carry out and perform its obligations under the terms of this Agreement, the Rights Agreement and the Securities (together, the “Transaction Agreements”). 

3.4. Authorization. The execution, delivery, and performance of the Transaction Agreements by the Company has been
duly authorized by all requisite action on the part of the Company and its officers, directors and stockholders, and the Transaction Agreements constitute the legal, valid, and binding obligations of the Company enforceable in accordance with their
terms, except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, and other laws of general application affecting enforcement of creditors’ rights generally, and (b) as limited by laws relating to the
availability of specific performance, injunctive relief or other equitable remedies. 

  
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 3.5. Consents and Approvals. Except for any Current Report on Form
8-K or Notice of Exempt Offering of Securities on Form D to be filed by the Company in connection with the transactions contemplated hereby, the Company is not required to give any notice to, make any filing with, or obtain any authorization,
consent, or approval of any government or governmental agency in order to consummate the transactions contemplated by the Transaction Agreements. No consent, approval, authorization or other order of, or registration, qualification or filing with,
any court, regulatory body, administrative agency, self-regulatory organization, stock exchange or market (including The NASDAQ Stock Market), or other governmental body is required for the execution and delivery of these Transaction Agreements, the
valid, sale and delivery of the Securities to be sold pursuant to this Agreement other than such as have been made or obtained, or for any securities filings required to be made under federal or state securities laws applicable to the offering of
the Securities. 
 3.6. Non-Contravention. The execution and delivery of the Transaction Agreements, the
issuance, sale and delivery of the Securities (including the issuance of the Underlying Securities upon conversion thereof) to be sold by the Company under this Agreement, the performance by the Company of its obligations under the Transaction
Agreements and/or the consummation of the transactions contemplated thereby will not (a) conflict with, result in the breach or violation of, or constitute (with or without the giving of notice or the passage of time or both) a violation of, or
default under, (i) any bond, debenture, note or other evidence of indebtedness, or under any lease, license, franchise, permit, indenture, mortgage, deed of trust, loan agreement, joint venture or other agreement or instrument to which the
Company or any subsidiary is a party or by which it or its properties may be bound or affected, (ii) the Company’s Restated Certificate of Incorporation, as amended and as in effect on the date hereof (the “Certificate of
Incorporation”), the Company’s Bylaws, as amended and as in effect on the date hereof (the “Bylaws”), or the equivalent document with respect to any subsidiary, as amended and as in effect on the date hereof, or
(iii) any statute or law, judgment, decree, rule, regulation, ordinance or order of any court or governmental or regulatory body (including The NASDAQ Stock Market), governmental agency, arbitration panel or authority applicable to the Company,
any of its subsidiaries or their respective properties, except in the case of clause (iii) for such conflicts, breaches, violations or defaults that would not be likely to have, individually or in the aggregate, a Material Adverse Effect, or
(b) result in the creation or imposition of any lien, encumbrance, claim, security interest or restriction whatsoever upon any of the material properties or assets of the Company or any of its subsidiaries or an acceleration of indebtedness
pursuant to any obligation, agreement or condition contained in any material bond, debenture, note or any other evidence of indebtedness or any material indenture, mortgage, deed of trust or any other agreement or instrument to which the Company or
any if its subsidiaries is a party or by which the Company or any of its subsidiaries is bound or to which any of the property or assets of the Company is subject. For purposes of this Section 3.6, the term “material” shall apply to
agreements, understandings, instruments, contracts or proposed transactions to which the Company is a party or by which it is bound involving obligations (contingent or otherwise) of, or payments to, the Company in excess of $100,000 in a 12-month
period. 
 3.7. The Securities. The Securities have been duly authorized by the Company and, when duly
executed and delivered and paid for as provided herein, will be duly and validly issued and outstanding and will constitute valid and legally binding obligations of the Company enforceable against the Company in accordance with their terms, subject
to the Enforceability Exceptions (as defined below). 

  
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 3.8. The Underlying Securities. Upon issuance and delivery of the
Securities in accordance with this Agreement, the Securities will be convertible at the option of the holder thereof into shares of the Underlying Securities in accordance with the terms of the Securities; the Underlying Securities reserved for
issuance upon conversion of the Securities have been duly authorized and reserved and, when issued upon conversion of the Securities in accordance with the terms of the Securities, will be validly issued, fully paid and non-assessable, and the
issuance of the Underlying Securities will not be subject to any preemptive or similar rights. 
 3.9. No
Registration. Assuming the accuracy of each of the representations and warranties of each Purchaser herein, the issuance by the Company of the Securities (including the issuance of the Underlying Securities upon conversion thereof) is exempt
from registration under the Securities Act of 1933, as amended (the “Securities Act”). 
 3.10.
Reporting Status. The Company is subject to the reporting requirements of the Securities Exchange Act of 1934, as amended (the “Exchange Act”), and has, in a timely manner, filed all documents and reports that the Company was
required to file pursuant to Section I.A.3.b of the General Instructions to Form S-3 promulgated under the Securities Act in order for the Company to be eligible to use Form S-3 for the two years preceding the Closing Date or such shorter time
period as the Company has been subject to such reporting requirements (the foregoing materials, together with any materials filed by the Company under the Exchange Act, whether or not required, collectively, the “SEC Documents”).
The SEC Documents complied as to form in all material respects with requirements of the Securities Act and Exchange Act and the rules and regulations of the U.S. Securities and Exchange Commission (the “SEC”) promulgated thereunder
(collectively, the “SEC Rules”), and none of the SEC Documents and the information contained therein, as of their respective filing dates, contained any untrue statement of a material fact or omitted to state a material fact
required to be stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading. As used in this Agreement, “Previously Disclosed” means information set
forth in or incorporated by reference into the SEC Documents filed with the SEC on or after March 14, 2011 but prior to the date hereof (except for risks and forward-looking information set forth in the “Risk Factors” section of the
applicable SEC Documents or in any forward-looking statement disclaimers or similar statements that are similarly non-specific and are predictive or forward-looking in nature). 

3.11. Contracts. Each indenture, contract, lease, mortgage, deed of trust, note agreement, loan or other agreement
or instrument of a character that is required to be described or summarized in the SEC Documents or to be filed as an exhibit to the SEC Documents under the SEC Rules (collectively, the “Material Contracts”) is so described,
summarized or filed. The Material Contracts to which the Company or its subsidiaries are a party have been duly and validly authorized, executed and delivered by the Company and constitute the legal, valid and binding agreements of the Company or
its subsidiaries, as applicable, enforceable by and against the Company or its subsidiaries, as applicable, in accordance with their respective terms, subject to applicable bankruptcy, insolvency, reorganization, or similar laws relating to or
affecting the enforcement of creditors’ rights (together, the “Enforceability Exceptions”). 
 3.12. Capitalization. Immediately prior to the Closing, the authorized capital stock of the Company consists of (a) 100,000,000 shares of Common Stock, $0.0001 par value per share, 51,072,102
shares of which are issued and outstanding as of the date hereof and an additional 5,190,310 shares of which are expected to be issued and outstanding at Closing upon receipt of funds from one of the

  
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purchasers under that certain Securities Purchase Agreement, dated as of February 22, 2012 (the “PIPE SPA”), by and among the Company and the purchasers identified therein,
and (b) 5,000,000 shares of Preferred Stock, $0.0001 par value per share, of which no shares were issued and outstanding. All subscriptions, warrants, options, convertible securities, and other rights (contingent or other) to purchase or
otherwise acquire equity securities of the Company issued and outstanding as of the date hereof, or material contracts, commitments, understandings, or arrangements by which the Company or any of its subsidiaries is or may be obligated to issue
shares of capital stock, or securities or rights convertible or exchangeable for shares of capital stock, are as set forth in the SEC Documents. The issued and outstanding shares of the Company’s capital stock have been duly authorized and
validly issued, are fully paid and nonassessable, have been issued in compliance with all applicable federal and state securities laws, and were not issued in violation of or subject to any preemptive rights or other rights to subscribe for or
purchase securities. Except as Previously Disclosed, no holder of the Company’s capital stock is entitled to preemptive or similar rights. There are no bonds, debentures, notes or other indebtedness having general voting rights (or convertible
into securities having such rights) of the Company issued and outstanding. Except as Previously Disclosed, there are no agreements or arrangements under which the Company or any of its subsidiaries is obligated to register the sale of any of their
securities under the Securities Act. The Company has made available upon request of the Purchasers, a true, correct and complete copy of the Company’s Certificate of Incorporation and Bylaws. 

3.13. Legal Proceedings. Except as Previously Disclosed, there is no action, suit or proceeding before any court,
governmental agency or body, domestic or foreign, now pending or, to the knowledge of the Company, threatened against the Company or its subsidiaries wherein an unfavorable decision, ruling or finding would reasonably be expected to, individually or
in the aggregate, (i) materially adversely affect the validity or enforceability of, or the authority or ability of the Company to perform its obligations under this Agreement or (ii) have a Material Adverse Effect. The Company is not a
party to or subject to the provisions of any injunction, judgment, decree or order of any court, regulatory body, administrative agency or other governmental agency or body that might have, individually or in the aggregate, a Material Adverse
Effect. 
 3.14. No Violations. Neither the Company nor any of its subsidiaries is in violation of its
respective certificate of incorporation, bylaws or other organizational documents, or to its knowledge, is in violation of any statute or law, judgment, decree, rule, regulation, ordinance or order of any court or governmental or regulatory body
(including The NASDAQ Stock Market), governmental agency, arbitration panel or authority applicable to the Company or any of its subsidiaries, which violation, individually or in the aggregate, would be reasonably likely to have a Material Adverse
Effect, or, except with respect to a breach of the financial covenant contained in Section 4(c)(ii) of that certain Letter Agreement re: Revolving Credit Facility by and between Bank of the West and the Company, dated December 23, 2010
(which breach is no longer continuing), is in default (and there exists no condition which, with or without the passage of time or giving of notice or both, would constitute a default) in the performance of any bond, debenture, note or any other
evidence of indebtedness in any indenture, mortgage, deed of trust or any other material agreement or instrument to which the Company or any of its subsidiaries is a party or by which the Company or any of its subsidiaries is bound or by which the
properties of the Company are bound, which would be reasonably likely to have a Material Adverse Effect. There has not been, and to the knowledge of the Company, there is not pending or contemplated, any investigation by the SEC involving the
Company or any current or former director or officer of the Company and the Company is not an “ineligible issuer” pursuant to Rules 164, 405 and 

  
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433 under the Securities Act. The Company has not received any comment letter from the SEC relating to any SEC Documents which has not been finally resolved. The SEC has not issued any stop order
or other order suspending the effectiveness of any registration statement filed by the Company under the Exchange Act or the Securities Act. 
 3.15. Governmental Permits; FDA Matters.  

(a) Permits. The Company and its subsidiaries possess all necessary franchises, licenses,
certificates and other authorizations from any foreign, federal, state or local government or governmental agency, department or body that are currently necessary for the operation of their respective businesses as currently conducted, except where
such failure to possess would not reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect. Neither the Company nor any of its subsidiaries has received any notice of proceedings relating to the revocation or
modification of any such permit which, if the subject of an unfavorable decision, ruling or finding, could reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect. 

(b) EPA and FDA Matters. As to each of the manufacturing processes, intermediate products and
research or commercial products of the Company and each of its subsidiaries, including, without limitation, products or compounds currently under research and/or development by the Company, subject to the jurisdiction of the United States
Environmental Protection Agency (“EPA”) under the Toxic Substances Control Act and regulations thereunder (“TSCA”) or the Food and Drug Administration (“FDA”) under the Federal Food, Drug and
Cosmetic Act and the regulations thereunder (“FDCA”) (each such product, a “Life Science Product”), such Life Science Product is being researched, developed, manufactured, tested, distributed and/or marketed in
compliance in all material respects with all applicable requirements under the FDCA and TSCA and similar laws and regulations applicable to such Life Science Product, including those relating to investigational use, premarket approval, good
manufacturing practices, labeling, advertising, record keeping, filing of reports and security. The Company has not received any notice or other communication from the FDA, EPA or any other federal, state or foreign governmental entity
(i) contesting the premarket approval of, the uses of or the labeling and promotion of any Life Science Product or (ii) otherwise alleging any violation by the Company of any law, regulation or other legal provision applicable to a Life
Science Product. Neither the Company, nor any officer, employee or agent of the Company has made an untrue statement of a material fact or fraudulent statement to the FDA or other federal, state or foreign governmental entity performing similar or
equivalent functions or failed to disclose a material fact required to be disclosed to the FDA or such other federal, state or foreign governmental entity. 
 3.16. Listing Compliance. The Company is in compliance with the requirements of the NASDAQ Global Select Market for continued listing of the Common Stock thereon and has no knowledge of any facts
or circumstances that could reasonably lead to delisting of its Common Stock from the NASDAQ Global Select Market. The Company has taken no action designed to, or likely to have the effect of, terminating the registration of the Common Stock under
the Exchange Act or the listing of the Common Stock on the NASDAQ Global Select Market, nor has the Company received any notification that the SEC or the NASDAQ Global Select Market is contemplating terminating such registration or listing. The
transactions contemplated by the Transaction Agreements will not contravene 

  
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the rules and regulations of the NASDAQ Global Select Market. The Company will comply with all requirements of the NASDAQ Global Select Market with respect to the issuance of the Securities
(including the issuance of the Underlying Securities upon conversion thereof), including the filing of any additional listing notice with respect to the issuance of the Securities (including the issuance of the Underlying Securities upon conversion
thereof). 
 3.17. Intellectual Property. 

(a) The Company and/or the subsidiaries owns or possesses, free and clear of all encumbrances, all legal
rights to all intellectual property and industrial property rights and rights in confidential information, including all (i) patents, patent applications, invention disclosures, and all related continuations, continuations-in-part, divisional,
reissues, re-examinations, substitutions and extensions thereof, (ii) trademarks, trademark rights, service marks, service mark rights, corporate names, trade names, trade name rights, domain names, logos, slogans, trade dress, design rights,
and other similar designations of source or origin, together with the goodwill symbolized by and of the foregoing, (iii) trade secrets and all other confidential information, ideas, know-how, inventions, proprietary processes, formulae, models,
and other methodologies, (iv) copyrights, (v) computer programs (whether in object code, subject code or other form), algorithms, databases, compilations and data, technology supporting the foregoing, and all related documentation,
(vi) licenses, and (vii) all applications and registrations of the foregoing, and (viii) all other similar proprietary rights (collectively, “Intellectual Property”) used or held for use in, or necessary for the
conduct of their businesses as now conducted and as proposed to be conducted, and neither the Company nor any of its subsidiaries (i) has received any communications alleging that either the Company or any of the subsidiaries has violated,
infringed or misappropriated or, by conducting their businesses as now conducted and as proposed to be conducted, would violate, infringe or misappropriate any of the Intellectual Property of any other person or entity, (ii) knows of any basis
for any claim that the Company or any of the subsidiaries has violated, infringed or misappropriated, or, by conducting their businesses as now conducted and as proposed to be conducted, would violate, infringe or misappropriate any of the
Intellectual Property of any other person or entity, and (iii) knows of any third-party infringement, misappropriation or violation of any Company or any Company subsidiary’s Intellectual Property. The Company has taken and takes
reasonable security measures to protect the secrecy, confidentiality and value of its Intellectual Property, including requiring all persons with access thereto to enter into appropriate non-disclosure agreements. To the knowledge of the Company,
there has not been any disclosure of any material trade secret of the Company or a Company subsidiary (including any such information of any other person or entity disclosed in confidence to the Company) to any other person or entity in a manner
that has resulted or is likely to result in the loss of trade secret in and to such information. Except as Previously Disclosed, and except as would not reasonably be expected to have, individually or in the aggregate, a Material Adverse Effect,
there are no outstanding options, licenses or agreements, claims, encumbrances or shared ownership interests of any kind relating to the Company’s or the subsidiaries’ Intellectual Property, nor is the Company or the subsidiaries bound by
or a party to any options, licenses or agreements of any kind with respect to the Intellectual Property of any other person or entity. 
 (b) To the Company’s knowledge, none of the employees of the Company or the subsidiaries are obligated under any contract (including, without limitation, licenses,

  
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covenants or commitments of any nature or contracts entered into with prior employers), or subject to any judgment, decree or order of any court or administrative agency, that would interfere
with the use of his or her best efforts to promote the interests of the Company or the subsidiaries or would conflict with their businesses as now conducted and as proposed to be conducted. Neither the execution nor delivery of the Transaction
Agreements will conflict with or result in a breach of the terms, conditions or provisions of, or constitute a default under any contract, covenant or instrument under which the Company or the subsidiaries or any of the employees of the Company or
the subsidiaries is now obligated, and neither the Company nor the subsidiaries will need to use any inventions that any of its employees, or persons it currently intends to employ, have made prior to their employment with the Company or the
subsidiaries, except for inventions that have been assigned or licensed to the Company or the subsidiaries as of the date hereof. Each current and former employee or contractor of the Company or the subsidiaries that has developed any Intellectual
Property owned or purported to be owned by the Company or the subsidiaries has executed and delivered to the Company a valid and enforceable Invention Assignment and Confidentiality Agreement that (i) assigns to the Company or such subsidiaries
all right, title and interest in and to any Intellectual Property rights arising from or developed or delivered to the Company or such subsidiaries in connection with such person’s work for or on behalf of the Company or such subsidiaries, and
(ii) provides reasonable protection for the trade secrets, know-how and other confidential information (1) of the Company or such subsidiaries and (2) of any third party that has disclosed same to the Company or such subsidiaries. To
the knowledge of the Company, no current or former employee, officer, consultant or contractor is in default or breach of any term of any employment, consulting or contractor agreement, non-disclosure agreement, assignment agreement, or similar
agreement. Except as Previously Disclosed, to the knowledge of the Company, no present or former employee, officer, consultant or contractor of the Company has any ownership, license or other right, title or interest, directly or indirectly, in
whole or in part, in any Intellectual Property that is owned or purported to be owned, in whole or part, by the Company or the subsidiaries. 
 3.18. Financial Statements. The consolidated financial statements of the Company and its subsidiaries and the related notes thereto included in the SEC Documents (the “Financial
Statements”) comply in all material respects with applicable accounting requirements and the rules and regulations of the SEC with respect thereto as in effect at the time of filing and present fairly, in all material respects, the
financial position of the Company and its subsidiaries as of the dates indicated and the results of its operations and cash flows for the periods therein specified subject, in the case of unaudited statements, to normal year-end audit adjustments.
Except as set forth in such Financial Statements (or the notes thereto), such Financial Statements (including the related notes) have been prepared in accordance with U.S. generally accepted accounting principles applied on a consistent basis
throughout the periods therein specified (“GAAP”). Except as set forth in the Financial Statements, neither the Company nor the subsidiaries has any material liabilities other than liabilities and obligations that have arisen in the
ordinary course of business and which would not be required to be reflected in financial statements prepared in accordance with GAAP. 
 3.19. Accountants. PricewaterhouseCoopers LLP, which has expressed its opinion with respect to the consolidated financial statements contained in the Company’s Annual Report on Form 10-K
for the year ended December 31, 2010, are registered independent public accountants as required by the Exchange Act and the rules and regulations promulgated thereunder (and by the rules of the Public Company Accounting Oversight Board). The
Company believes that the opinion of 

  
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PricewaterhouseCoopers LLP with respect to the consolidated financial statements contained in the Company’s Annual Report on Form 10-K for the year ended December 31, 2011 shall contain
no “going concern” opinions. The Company shall use its best efforts to ensure that the opinion of PricewaterhouseCoopers LLP with respect to such consolidated financial statements do not contain any “going concern” opinions.

 3.20. Internal Accounting Controls. The Company maintains a system of internal accounting controls
sufficient to provide reasonable assurances that (i) transactions are executed in accordance with management’s general or specific authorizations; (ii) transactions are recorded as necessary to permit preparation of financial
statements in conformity with GAAP and to maintain accountability for assets; (iii) access to assets is permitted only in accordance with management’s general or specific authorization; and (iv) the recorded accountability for assets
is compared with existing assets at reasonable intervals and appropriate action is taken with respect to any differences. The Company has disclosure controls and procedures (as defined in Rules 13a-14 and 15d-14 under the Exchange Act) that are
effective and designed to ensure that (i) information required to be disclosed in the reports that it files or submits under the Exchange Act is recorded, processed, summarized and reported, within the time periods specified by the SEC Rules,
and (ii) such information is accumulated and communicated to the Company’s management, including its principal executive officer and principal financial officer, to allow timely decisions regarding required disclosure. The Company is
otherwise in compliance in all material respects with all applicable provisions of the Sarbanes-Oxley Act of 2002, as amended and the rules and regulations promulgated thereunder. 

3.21. Off-Balance Sheet Arrangements. There is no transaction, arrangement or other relationship between the
Company or its subsidiaries and an unconsolidated or other off-balance sheet entity that is required to be disclosed by the Company in its Exchange Act filings and is not so disclosed or that otherwise would be reasonably likely to have,
individually or in the aggregate, a Material Adverse Effect. There are no such transactions, arrangements or other relationships with the Company that may create contingencies or liabilities that are not otherwise disclosed by the Company in its
Exchange Act filings. 
 3.22. No Material Adverse Change. Except as set forth in (i) the SEC
Documents in each case, filed or made through and including the date hereof, since September 30, 2011, or (ii) the written transcript of the Company’s webcast conference call held at 5:00 p.m. E.S.T. on February 9, 2012
previously made available to the Purchasers and/or their respective counsel: 
 (a) there has not
been any event, occurrence or development that, individually or in the aggregate, has had or that could reasonably be expected to result in a Material Adverse Effect, 

(b) the Company has not incurred any liabilities (contingent or otherwise) other than (1) trade
payables and accrued expenses incurred in the ordinary course of business consistent with past practice and (2) liabilities not required to be reflected in the Company’s financial statements pursuant to GAAP or not required to be disclosed
in filings made with the SEC, 
 (c) the Company has not declared or made any dividend or
distribution of cash or other property to its stockholders or purchased, redeemed or made any agreements to 

  
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purchase or redeem any shares of its capital stock other than routine withholding in accordance with the Company’s existing stock-based plan, 

(d) the Company has not altered its method of accounting or the identity of its auditors, except as
Previously Disclosed, 
 (e) the Company has not issued any equity securities except: 

(i) pursuant to the Company’s existing stock-based plan, 

(ii) warrants to purchase 21,087 shares of the Company’s Common Stock issued to Atel Ventures, Inc.
in its capacity as trustee for its assignee affiliated funds pursuant to that certain Warrant to Purchase Common Stock dated as of December 23, 2011, and (iii) 362,319 shares of the Company’s Common Stock issued to Draths Corporation,
a Delaware corporation (“Draths”) as partial consideration for the Company’s acquisition of substantially all the assets of Draths pursuant to that certain Asset Purchase Agreement, dated as of October 6, 2011, between the
Company and Draths, 
 (iii) 4,970,015 shares of Common Stock issued, and 5,190,310 shares of
Common Stock issuable, pursuant to the PIPE SPA, and 
 (f) there has not been any loss or damage
(whether or not insured) to the physical property of the Company or any of its subsidiaries. 

The Company is not as of the date hereof, and after giving effect to the transactions contemplated hereby
to occur at the Closing, will not be Insolvent (as defined below). For purposes of this Section, “Insolvent” means, with respect to any person, (i) the present fair saleable value of such person’s assets is less than the
amount required to pay such person’s total indebtedness, (ii) such person is unable to pay its debts and liabilities, subordinated, contingent or otherwise, as such debts and liabilities become absolute and matured, (iii) such person
intends to incur or believes that it will incur debts that would be beyond its ability to pay as such debts mature or (iv) such person has unreasonably small capital with which to conduct the business in which it is engaged as such business is
now conducted and is currently proposed to be conducted. 
 3.23. No Manipulation of Stock. Neither the
Company nor any of its subsidiaries, nor to the Company’s knowledge, any of their respective officers, directors, employees, affiliates or controlling persons has taken and will not, in violation of applicable law, take, any action designed to
or that might reasonably be expected to, directly or indirectly, cause or result in stabilization or manipulation of the price of the Common Stock. 
 3.24. Insurance. The Company and its subsidiaries are insured by insurers of recognized financial responsibility against such losses and risks and in such amounts as are prudent and customary in
the businesses in which the Company and the subsidiaries are engaged. The Company and its subsidiaries will continue to maintain such insurance or substantially similar insurance, which covers the same risks at the same levels as the existing
insurance with insurers which guarantee the same financial responsibility as the current insurers, and neither the Company nor any subsidiary has any reason to 

  
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believe that it will not be able to renew its existing insurance coverage as and when such coverage expires or to obtain similar coverage from similar insurers as may be necessary to continue its
business without a significant increase in cost. 
 3.25. Properties. The Company and its subsidiaries
have good and marketable title to all the properties and assets (both tangible and intangible) described as owned by them in the consolidated financial statements included in the SEC Documents, free and clear of all liens, mortgages, pledges, or
encumbrances of any kind except (i) those, if any, reflected in such consolidated financial statements (including the notes thereto), or (ii) those that are not material in amount and do not adversely affect the use made and proposed to be
made of such property by the Company or its subsidiaries. The Company and each of its subsidiaries hold their leased properties under valid and binding leases. The Company and each of its subsidiaries own or lease all such properties as are
necessary to its operations as now conducted. 
 3.26. Tax Matters. The Company and the subsidiaries have
filed all Tax Returns, and these Tax Returns are true, correct, and complete in all material respects. The Company and each subsidiary (i) have paid all Taxes that are due from the Company or such subsidiary for the periods covered by the Tax
Returns or (ii) have duly and fully provided reserves adequate to pay all Taxes in accordance with GAAP. No agreement as to indemnification for, contribution to, or payment of Taxes exists between the Company or any subsidiary, on the one hand,
and any other person, on the other, including pursuant to any Tax sharing agreement, lease agreement, purchase or sale agreement, partnership agreement or any other agreement not entered into in the ordinary course of business. Neither the Company
nor any of its subsidiaries has any liability for Taxes of any person (other than the Company or any of its subsidiaries) under Treasury Regulation Section 1.1502-6 (or any similar provision of any state, local or foreign law), or as a
transferee or successor, by contract or otherwise. Since the date of the Company’s most recent Financial Statements, the Company has not incurred any liability for Taxes other than in the ordinary course of business consistent with past
practice. Neither the Company nor the subsidiaries has been advised (a) that any of its Tax Returns have been or are being audited as of the date hereof, or (b) of any deficiency in assessment or proposed judgment to its Taxes. Neither the
Company nor any of its subsidiaries has knowledge of any Tax liability to be imposed upon its properties or assets as of the date of this Agreement that is not adequately provided for. The Company has not distributed stock of another corporation, or
has had its stock distributed by another corporation, in a transaction that was governed, or purported or intended to be governed, in whole or in part, by Section 355 of the Internal Revenue Code (i) in the two years prior to the date of
this Agreement or (ii) in a distribution that could otherwise constitute part of a “plan” or “series of related transactions” (within the meaning of Section 334(e) of the Internal Revenue Code) in conjunction with the
purchase of the Securities. “Tax” or “Taxes” means any foreign, federal, state or local income, gross receipts, license, payroll, employment, excise, severance, stamp, occupation, premium, property, windfall,
profits, environmental, customs, capital stock, franchise, employees’ income withholding, foreign or domestic withholding, social security, unemployment, disability, real property, personal property, sales, use, transfer, value added,
alternative or add-on minimum or other similar tax, governmental fee, governmental assessment or governmental charge, including any interest, penalties or additions to Taxes or additional amounts with respect to the foregoing. “Tax
Returns” means all returns, reports, or statements required to be filed with respect to any Tax (including any elections, notifications, declarations, schedules or attachments thereto, and any amendment thereof) including any information
return, claim for refund, amended return or declaration of estimated Tax. 

  
 11 

 3.27. Investment Company Status. The Company is not, and immediately
after receipt of payment for the Securities will not be, an “investment company,” an “affiliated person” of, “promoter” for or “principal underwriter” for, or an entity “controlled” by an
“investment company,” within the meaning of the Investment Company Act of 1940, as amended, or the rules and regulations promulgated thereunder. 
 3.28. Transactions With Affiliates and Employees. Except as Previously Disclosed, none of the officers or directors of the Company or its subsidiaries and, to the knowledge of the Company, none of
the employees of the Company or its subsidiaries is presently a party to any transaction with the Company or any subsidiary (other than for services as employees, officers and directors required to be disclosed under Item 404 of Regulation S-K
under the Exchange Act). 
 3.29. Foreign Corrupt Practices. Neither the Company nor its subsidiaries or
affiliates, any director or officer, nor to the knowledge of the Company, any agent, employee or other Person acting on behalf of the Company or its subsidiaries has, in the course of its actions for, or on behalf of, the Company or any of its
subsidiaries (a) used any corporate funds for any unlawful contribution, gift, entertainment or other unlawful expenses relating to political activity, (b) made or promised to make any direct or indirect unlawful payment to any foreign or
domestic government official or employee (including any officer or employee of a government or government-owned or controlled entity or of a public international organization, or any person acting in an official capacity for or on behalf of any of
the foregoing, or of any political party or part official or candidate for political office (each such person, a “Government Official”)) from corporate funds, (c) violated or is in violation of any provision of the U.S. Foreign
Corrupt Practices Act of 1977, as amended or (d) made or promised to make any unlawful bribe, rebate, payoff, influence payment, kickback or other unlawful payment to any foreign or domestic Government Official. 

3.30. Money Laundering Laws. The operations of the Company and its subsidiaries are and have been conducted at all
times in compliance with applicable financial record-keeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, and the Bank Secrecy Act, as amended by Title III of the Uniting and Strengthening
America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act of 2001 (Title III of Pub. L. 107-56 (signed into law on October 26, 2001)), applicable money laundering statutes and applicable rules and regulations
thereunder (collectively, the “Money Laundering Laws”), and no action, suit or proceeding by or before any court or governmental agency, authority or body or any arbitrator involving the Company or any of its subsidiaries with
respect to the Money Laundering Laws is pending or, to the Company’s knowledge, threatened. 
 3.31.
OFAC. Neither the Company, any director or officer, nor, to the Company’s knowledge, any agent, employee, subsidiary or affiliate of the Company is currently subject to any U.S. sanctions administered by the Office of Foreign Assets
Control of the U.S. Treasury Department (“OFAC”); and the Company will not directly or indirectly use the proceeds of the offering, or lend, contribute or otherwise make available such proceeds to any subsidiary, joint venture
partner or other person or entity, for the purpose of financing the activities of any person currently subject to any U.S. sanctions administered by OFAC. 
 3.32. Environmental Laws. The Company and its subsidiaries (i) are in compliance with any and all applicable foreign, federal, state and local laws and regulations relating to the protection
of 

  
 12 

 
human health and safety, the environment or hazardous or toxic substances or wastes, pollutants or contaminants (“Environmental Laws”), (ii) have received all permits,
licenses or other approvals required of them under applicable Environmental Laws to conduct their respective businesses and (iii) are in compliance with all terms and conditions of any such permit, license or approval, except where such
noncompliance with Environmental Laws, failure to receive required permits, licenses or other approvals or failure to comply with the terms and conditions of such permits, licenses or approvals would not, singly or in the aggregate, have a Material
Adverse Effect on the Company and its subsidiaries, taken as a whole. There are no costs or liabilities associated with Environmental Laws (including, without limitation, any capital or operating expenditures required for clean-up, closure of
properties or compliance with Environmental Laws or any permit, license or approval, any related constraints on operating activities and any potential liabilities to third parties) which would, singly or in the aggregate, have a Material Adverse
Effect on the Company and its subsidiaries, taken as a whole. 
 3.33. Employee Relations. Neither the
Company nor any of its subsidiaries is a party to any collective bargaining agreement or employs any member of a union. Neither the Company nor any of its subsidiaries is engaged in any unfair labor practice. There is (i) (x) no unfair
labor practice complaint pending or, to the Company’s knowledge, threatened against the Company or any of its subsidiaries before the National Labor Relations Board, and no grievance or arbitration proceeding arising out of or under collective
bargaining agreements is pending or threatened, (y) no strike, labor dispute, slowdown or stoppage pending or, to the Company’s knowledge, threatened against the Company or any of its subsidiaries and (z) no union representation
dispute currently existing concerning the employees of the Company or any of its subsidiaries, and (ii) to the Company’s knowledge, (x) no union organizing activities are currently taking place concerning the employees of the Company
or any of its subsidiaries and (y) there has been no violation of any federal, state, local or foreign law relating to discrimination in the hiring, promotion or pay of employees or any applicable wage or hour laws. Except as Previously
Disclosed, no executive officer of the Company (as defined in Rule 501(f) promulgated under the Securities Act) has notified the Company that such officer intends to leave the Company or otherwise terminate such officer’s employment
with the Company. No executive officer of the Company, to the knowledge of the Company, is, or is now expected to be, in violation of any material term of any employment contract, confidentiality, disclosure or proprietary information agreement,
non-competition agreement, or any other agreement or any restrictive covenant, and the continued employment of each such executive officer does not subject the Company or any of its subsidiaries to any liability with respect to any of the foregoing
matters. 
 3.34. ERISA. The Company and its subsidiaries are in compliance in all material respects with
all presently applicable provisions of the Employee Retirement Income Security Act of 1974, as amended, including the regulations and published interpretations thereunder (herein called “ERISA”); no “reportable event” (as
defined in ERISA) has occurred with respect to any “pension plan” (as defined in ERISA) for which the Company or any of its subsidiaries would have any liability; the Company has not incurred and does not expect to incur liability under
(i) Title IV of ERISA with respect to termination of, or withdrawal from, any “pension plan”; or (ii) Sections 412 or 4971 of the Internal Revenue Code of 1986, as amended, including the regulations and published interpretations
thereunder (the “Code”); and each “Pension Plan” for which the Company would have liability that is intended to be qualified under Section 401(a) of the Code is so qualified in all material respects and nothing
has occurred, whether by action or by failure to act, which would cause the loss of such qualification. 

  
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 3.35. Obligations of Management. To the Company’s knowledge,
each officer and key employee of the Company or the subsidiaries is currently devoting substantially all of his or her business time to the conduct of the business of the Company or the subsidiaries, respectively. Except as Previously Disclosed, the
Company is not aware that any officer or key employee of the Company or the subsidiaries is planning to work less than full time at the Company or the subsidiaries, respectively, in the future. To the Company’s knowledge, no officer or key
employee is currently working or plans to work for a competitive enterprise, whether or not such officer or key employee is or will be compensated by such enterprise. To the Company’s knowledge, no officer or person currently nominated to
become an officer of the Company or the subsidiaries is or has been subject to any judgment or order of, the subject of any pending civil or administrative action by the SEC or any self-regulatory organization. 

3.36. Integration; Other Issuances of Securities. Neither the Company nor its subsidiaries or any affiliates, nor
any person acting on its or their behalf, has issued any shares of Common Stock or shares of any series of preferred stock or other securities or instruments convertible into, exchangeable for or otherwise entitling the holder thereof to acquire
shares of Common Stock which would be integrated with the sale of the Securities to the Purchasers for purposes of the Securities Act or of any applicable stockholder approval provisions, including, without limitation, under the rules and
regulations of The NASDAQ Stock Market, nor will the Company or its subsidiaries or affiliates take any action or steps that would require registration of any of the Securities under the Securities Act or cause the offering of the Securities to be
integrated with other offerings if any such integration would cause the issuance of the Securities hereunder to fail to be exempt from registration under the Securities Act as provided in Section 3.8 above or cause the transactions contemplated
hereby to contravene the rules and regulations of the NASDAQ Global Select Market. The Company is eligible to register the Underlying Securities for resale by the Purchasers using Form S-3 promulgated under the Securities Act. 

3.37. No General Solicitation. Neither the Company nor its subsidiaries or any affiliates, nor any person acting
on its or their behalf, has offered or sold any of the Securities by any form of general solicitation or general advertising. 
 3.38. No Brokers’ Fees. The Company has not incurred any liability for any finder’s or broker’s fee or agent’s commission in connection with the execution and delivery of this
Agreement or the consummation of the transactions contemplated hereby. 
 3.39. Registration Rights.
Except as set forth in (i) the Amended and Restated Investors’ Rights Agreement dated June 21, 2010, by and between the Company and the parties listed on Exhibits A through G thereof, as amended by Amendment Number 1 thereto dated as
of February 23, 2012, and (ii) the Rights Agreement, the Company has not granted or agreed to grant to any person any rights (including “piggy-back” registration rights) to have any securities of the Company registered with the
SEC or any other governmental authority that have not been satisfied or waived. 
 3.40. Application of
Takeover Protections. There is no control share acquisition, business combination, poison pill (including any distribution under a rights agreement) or other similar anti-takeover provision under the Company’s charter documents or the laws
of its state of incorporation that is or could become applicable to any of the Purchasers as a result of the Purchaser and the Company fulfilling their obligations or exercising their rights under the Transaction Agreements, including,

  
 14 

 
without limitation, as a result of the Company’s issuance of the Securities (including the issuance of the Underlying Securities upon conversion thereof) and the Purchasers’ ownership
of the Securities. 
 3.41. Disclosure. The Company confirms that it has not provided, and none of its
officers or directors nor, to the Company’s knowledge, any other Person acting on its or their behalf has provided any Purchaser or its respective agents or counsel with any information that it believes constitutes material, non-public
information except insofar as the existence, provisions and terms of the Transaction Agreements and the proposed transactions hereunder may constitute such information, all of which will be disclosed by the Company in the Press Release as
contemplated by Section 8.1 hereof. The Company understands and confirms that the Purchasers will rely on the foregoing representations in effecting transactions in securities of the Company. All disclosure furnished by or on behalf of the
Company to the Purchasers regarding the Company, its business and the transactions contemplated hereby is true and correct and does not contain any untrue statement of a material fact or omit to state any material fact necessary in order to make the
statements made therein not misleading. The Company acknowledges and agrees that no Purchaser makes or has made any representations or warranties with respect to the transactions contemplated hereby other than those specifically set forth in Article
4 hereto. 
 ARTICLE 4 
 REPRESENTATIONS AND WARRANTIES OF THE PURCHASER 
 Each Purchaser, as to itself only and not with respect to any other Purchaser, represents, warrants and covenants to the Company with respect to this purchase as follows: 

4.1. Organization. The Purchaser is duly organized, validly existing, and in good standing under the laws of the
jurisdiction of its organization. 
 4.2. Power. The Purchaser has all requisite power to execute and
deliver this Agreement and to carry out and perform its obligations under the terms of this Agreement. 
 4.3.
Authorization. The execution, delivery, and performance of this Agreement by the Purchaser has been duly authorized by all requisite action, and this Agreement constitutes the legal, valid, and binding obligation of the Purchaser enforceable
in accordance with its terms, except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, and other laws of general application affecting enforcement of creditors’ rights generally, and (b) as limited by
laws relating to the availability of specific performance, injunctive relief or other equitable remedies. 

4.4. Consents and Approvals. The Purchaser need not give any notice to, make any filing with, or obtain any
authorization, consent, or approval of any government or governmental agency in order to consummate the transactions contemplated by this Agreement. 
 4.5. Non-Contravention. Neither the execution and the delivery of this Agreement, nor the consummation of the transactions contemplated hereby, will violate in any material respect any
constitution, statute, regulation, rule, injunction, judgment, order, decree, ruling, charge, or other restriction of any government, governmental agency, or court to which the Purchaser is subject. No approval, waiver, or consent by the Purchaser
under any instrument, contract, or agreement to which the Purchaser or any of its affiliates is a party is necessary to consummate the transactions contemplated hereby. 

  
 15 

 4.6. Purchase for Investment Only. The Purchaser is purchasing the
Securities for the Purchaser’s own account for investment purposes only and not with a view to, or for resale in connection with, any “distribution” in violation of the Securities Act. By executing this Agreement, the Purchaser
further represents that it does not have any contract, undertaking, agreement, or arrangement with any person to sell, transfer, or grant participation to such person or to any third person, with respect to any of the Securities. The Purchaser
understands that the Securities have not been registered under the Securities Act or any applicable state securities laws by reason of a specific exemption therefrom that depends upon, among other things, the bona fide nature of the investment
intent as expressed herein. 
 4.7. Disclosure of Information. The Purchaser has had an opportunity to
review the Company’s filings under the Securities Act and the Exchange Act (including risks factors set forth therein) and the Purchaser represents that it has had an opportunity to ask questions and receive answers from the Company to evaluate
the financial risk inherent in making an investment in the Securities. To the Purchaser’s knowledge, the Purchaser has not been offered the opportunity to purchase the Securities by means of any general solicitation or general advertising.

 4.8. Risk of Investment. The Purchaser realizes that the purchase of the Securities will be a highly
speculative investment and the Purchaser may suffer a complete loss of its investment. The Purchaser understands all of the risks related to the purchase of the Securities. By virtue of the Purchaser’s experience in evaluating and investing in
private placement transactions of securities in companies similar to the Company, the Purchaser is capable of evaluating the merits and risks of the Purchaser’s investment in the Company and has the capacity to protect the Purchaser’s own
interests. 
 4.9. Advisors. The Purchaser has reviewed with its own tax advisors the federal, state, and
local tax consequences of this investment and the transactions contemplated by this Agreement. The Purchaser acknowledges that it has had the opportunity to review the Transaction Agreements and the transactions contemplated thereby with the
Purchaser’s own legal counsel. 
 4.10. Finder. The Purchaser is not obligated and will not be
obligated to pay any broker commission, finders’ fee, success fee, or commission in connection with the transactions contemplated by this Agreement. 
 4.11. Restricted Securities. The Purchaser understands that the Securities must be held indefinitely unless subsequently registered under the Securities Act or unless an exemption from registration
is otherwise available. Moreover, the Purchaser understands that except as set forth in the Rights Agreement, the Company is under no obligation to register the Securities. The Purchaser is aware of Rule 144 promulgated under the Securities Act that
permits limited resales of securities purchased in a private placement subject to the satisfaction of certain conditions. 
 4.12. Legend. It is understood by the Purchaser that the Security and any other document representing or evidencing the Securities shall be endorsed with a legend substantially in the following
form: 
 THE SECURITIES REPRESENTED BY THIS NOTE AND THE SECURITIES ISSUABLE UPON ITS CONVERSION HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR SECURITIES LAWS OF ANY STATE AND MAY NOT 

  
 16 

 
BE OFFERED, SOLD, ASSIGNED, PLEDGED TRANSFERRED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN
AVAILABLE EXEMPTION FROM REGISTRATION UNDER THE ACT OR SUCH LAWS AND, IF REASONABLY REQUESTED BY THE COMPANY, UPON DELIVERY OF AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT THE PROPOSED TRANSFER IS EXEMPT FROM THE ACT OR SUCH
LAWS. THIS NOTE IS ALSO SUBJECT TO THE TRANSFER RESTRICTIONS CONTAINED IN THE SECURITIES PURCHASE AGREEMENT, DATED AS OF FEBRUARY 24, 2012, AMONG THE COMPANY AND THE PURCHASERS NAMED THEREIN.” 

Subject to Section 8.3, the Company need not register a transfer of Securities unless the conditions specified in the
foregoing legend are satisfied. Subject to Section 8.3, the Company may also instruct its transfer agent not to register the transfer of any of the Securities unless the conditions specified in the foregoing legend are satisfied. 

4.13. Investor Qualification. The Purchaser is an “accredited investor” as defined in Rule 501(a) of
Regulation D under the Securities Act. 
 ARTICLE 5 

CONDITIONS TO COMPANY’S OBLIGATIONS AT THE CLOSING. 

The Company’s obligation to complete the sale and issuance of the Securities and deliver the
Securities to each Purchaser, individually, at the Closing shall be subject to the following conditions to the extent not waived by the Company: 
 (a) Receipt of Payment. The Company shall have received payment, by wire transfer of immediately available funds, in the full amount of the Total Purchase Price for the Securities being purchased
by such Purchaser at the Closing as set forth next to such Purchaser’s name on Schedule I hereto. 
 (b) Representations and Warranties. The representations and warranties made by such Purchaser in Section 4 hereof shall be true and correct in all material respects as of, and as if made on,
the date of this Agreement and as of the Closing. 
 (c) Receipt of Executed Documents.
Such Purchaser shall have executed and delivered to the Company the Rights Agreement, duly executed by such Purchaser. 

ARTICLE 6 

CONDITIONS TO PURCHASERS’ OBLIGATIONS AT THE CLOSING 

Each Purchaser’s obligation to accept delivery of the Securities and to pay for the Securities shall
be subject to the following conditions to the extent not waived by such Purchaser: 

  
 17 

 (a) Representations and Warranties. The
representations and warranties made by the Company in Section 3 hereof shall be true and correct in all respects as of, and as if made on, the date of this Agreement and as of the Closing. 

(b) Receipt of Related Documents. The Company shall have executed and delivered to such Purchaser
the Rights Agreement and to such Purchaser’s Custodian, as identified on Schedule I hereto, such Purchaser’s Security. 
 (d) Legal Opinion. The Purchasers shall have received an opinion of Fenwick & West LLP, counsel to the Company, substantially in the form set forth in Exhibit C hereto. 

(d) Certificate. Each Purchaser shall have received a certificate signed by the Company’s
Chief Executive Officer and Chief Financial Officer to the effect that the representations and warranties of the Company in Section 3 hereof are true and correct in all respects as of, and as if made on, the date of this Agreement and as of the
Closing and that the Company has satisfied in all material respects all of the conditions set forth in this Agreement. 
 (e) Good Standing. The Company is validly existing as a corporation in good standing under the laws of Delaware as evidenced by a certificate of the Secretary of State of the State of Delaware, a
copy of which was provided to the Purchasers. 
 (f) Receipt of Minimum Funds. The Company
shall have received (i) payments totaling at least $43,726,682.60 in aggregate from the sale of 7,565,170 shares of its Common Stock to investors pursuant to the PIPE SPA, and (ii) irrevocable commitments for payments totaling at least
$14,999,995.90 for the pending sales of 2,595,155 shares of its Common Stock to investors pursuant to the PIPE SPA, and the Company shall have provided to each Purchaser a certificate signed by the Company’s Chief Executive Officer and Chief
Financial Officer to that effect. 
 (g) Secretary’s Certificate. A certificate,
executed by the Secretary of the Company and dated as of the Closing Date, as to (A) the resolutions approving the issuance of the Securities (including the issuance of the Underlying Securities upon conversion thereof) as adopted by an
Independent Committee of the Board of Directors and/or the Company’s Board of Directors in a form reasonably acceptable to such Purchaser, (B) the certificate of incorporation, and (C) the bylaws, each as in effect as of the Closing
Date. 
 (h) Board Approval. The terms and conditions of the issuance of the Securities
(including the issuance of the Underlying Securities upon conversion thereof) and the Transaction Agreements shall have been approved by an Independent Committee of the Board of Directors and/or a majority of the disinterested directors of the Board
of Directors, as applicable. 
 (i) Approvals. The Company shall have obtained all
governmental, regulatory or third party consents and approvals, if any, and given all notices, if any, necessary for the sale of the Securities, including, without limitation, from the NASDAQ Global Select Market. 

  
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 ARTICLE 7 
 COVENANTS OF THE COMPANY 
 7.1. Payment of Principal and
Interest. The Company covenants and agrees that it will duly and punctually pay the principal of and interest on the Securities in accordance with the terms of such Securities. 

7.2. Stay, Extension and Usury Laws. The Company covenants (to the extent that it may lawfully do so) that it will
not at any time insist upon, plead, or in any manner whatsoever claim or take the benefit or advantage of, any stay, extension or usury law wherever enacted, now or at any time hereafter in force, which may affect the covenants or the performance of
the Securities; and the Company (to the extent it may lawfully do so) hereby expressly waives all benefit or advantage of any such law. 
 7.3. Corporate Existence. Subject to Section 7 of the Securities, the Company will do or cause to be done all things necessary to preserve and keep in full force and effect its corporate
existence in accordance with its organizational documents and the rights (charter and statutory), licenses and franchises of the Company; provided, however, that the Company shall not be required to preserve any such right, license or franchise if
the Board of Directors of the Company shall determine that the preservation thereof is no longer desirable in the conduct of the business of the Company and that the loss thereof is not adverse in any material respect to the Purchasers. 

7.4. Taxes. The Company shall pay prior to delinquency all taxes, assessments and governmental levies, except as
contested in good faith and by appropriate proceedings. 
 ARTICLE 8 

OTHER AGREEMENTS OF THE PARTIES 
 8.1. Securities Laws Disclosure; Publicity. Prior to the opening of trading on the NASDAQ Global Select Market on February 27, 2012, the Company shall issue a press release (the “Press
Release”) acceptable to the Purchasers disclosing all material terms of the transactions contemplated hereby. On or before 5:30 p.m., New York City time, on the fourth Business Day immediately following the execution of this Agreement, the
Company will file a Current Report on Form 8-K with the SEC describing the terms of the Transaction Agreements. Notwithstanding the foregoing, the Company shall not publicly disclose the name of any Purchaser or an affiliate of any Purchaser, or
include the name of any Purchaser or an affiliate of any Purchaser in any press release or filing with the SEC or any regulatory agency or trading market, without the prior written consent of such Purchaser, except (i) as required by federal
securities law in connection with (A) any registration statement contemplated by the Rights Agreement and (B) the filing of final Transaction Agreements (including signature pages thereto) with the SEC and (ii) to the extent such
disclosure is required by law, request of the Staff of the SEC or trading market regulations, in which case the Company shall provide the Purchasers with prior written notice of such disclosure permitted under this subclause (ii). From and after the
issuance of the Press Release, the Company represents that no Purchaser shall be in possession of any material, non-public information received from the Company or any of its officers, directors, employees or agents, that is not disclosed in the
Press Release. Each Purchaser, until such time as the 

  
 19 

 
transactions contemplated by this Agreement are required to be publicly disclosed by the Company as described in this Section 8.1, will maintain the confidentiality of all disclosures made
to it in connection with this transaction (including the existence and terms of this transaction). 
 8.2.
Form D. The Company agrees to timely file a Form D with respect to the Securities as required under Regulation D and to provide a copy thereof to the Purchaser (provided that the posting of the Form D on the SEC’s EDGAR
system shall be deemed delivery of the Form D for purposes of this Agreement). 
 8.3. Removal of Legend and
Transfer Restrictions. The Company hereby covenants with the Purchasers to promptly, and in no event later than three trading days following the delivery by the Purchaser to the Company of the Security (endorsed or with stock powers attached,
signatures guaranteed, and otherwise in form necessary to affect the reissuance and/or transfer), in connection with the transfer or sale of all or a portion of the Securities pursuant to (1) an effective registration statement that is
effective at the time of such sale or transfer, (2) a transaction exempt from the registration requirements of the Securities Act in which the Company, if reasonably requested, receives an opinion of counsel reasonably satisfactory to the
Company that the Securities are freely transferable and that the legend is no longer required on such Security, or (3) an exemption from registration pursuant to Rule 144, deliver or cause the Company’s transfer agent to deliver to the
transferee of the Securities or to the Purchaser, as applicable, a new Security representing such Securities that is free from all restrictive and other legends. The Company acknowledges that the remedy at law for a breach of its obligations under
this Section 8.3 may be inadequate and agrees, in the event of a breach or threatened breach by the Company of the provisions of this Section 8.3 with respect to any Purchaser, the Purchaser shall be entitled, in addition to all other
available remedies, to an order and/or injunction restraining any breach and requiring immediate issuance and transfer, without the necessity of showing economic loss and without any bond or other security being required. 

8.4. Use of Proceeds. The Company agrees to use the proceeds of the offering for bona fide general corporate
purposes and to provide working capital. Following the Closing, the Company shall promptly take all necessary action required to cure the financial covenant default referenced in Section 3.13 hereof (to the extent such breach is not
automatically cured at Closing upon the Company receipt of the Total Purchase Price from the Purchasers). 

8.5. Subsequent Securities Sales. The Company shall not, and shall use its commercially reasonable efforts to
ensure that no affiliate of the Company shall, sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined in Section 2 of the Securities Act) that will be integrated with the offer or sale of the
Securities in a manner that would require the registration under the Securities Act of the sale of the Securities to the Purchasers, or that will be integrated with the offer or sale of the Securities for purposes of the rules and regulations of any
trading market such that it would require stockholder approval prior to the closing of such other transaction unless stockholder approval is obtained before the closing of such subsequent transaction. 

8.6. Listing; SEC Compliance. 

(a) Listing. The Company shall promptly take any action required to maintain the listing of all of
the Underlying Securities upon each national securities exchange and automated quotation system, if any, upon which shares of Common Stock are then listed (subject to official 

  
 20 

 
notice of issuance) and shall maintain, so long as any other shares of Common Stock shall be so listed, such listing of the Underlying Securities from time to time issuable under the terms of the
Securities. The Company shall not take any action which would be reasonably expected to result in the delisting or suspension of the Common Stock on The NASDAQ Stock Market. 

(b) SEC Filings. The Company shall take all actions within its control to comply with the reporting
requirements of the Exchange Act and each applicable national securities exchange and automated quotation system on which the Common Stock is listed. The Purchasers’ sole remedy for breach of this Section 8.6(b) will be as set forth in
Section 5 of the Securities. 
 (c) Current Information. The Company shall make and
keep public information available, as those terms are understood and defined in SEC Rule 144 for so long as required in order to permit the resale of the Securities or Underlying Securities pursuant to SEC Rule 144. 

8.7. Register. The Company shall keep a “register” which shall provide for the recordation of the name
and address of, and the amount of outstanding principal and interest owing to, each Purchaser. The entries in the register shall be conclusive evidence of the amounts due and owing to each Purchaser in the absence of manifest error. The Company and
each Purchaser shall treat each person whose name is recorded in the register pursuant to the terms hereof as a Purchaser for all purposes. The obligations of the Company to each Purchaser under the Securities (the “Obligations”)
are registered obligations and the right, title and interest of any Purchaser and its assignees in and to such Obligations shall be transferable only upon notation of such transfer in the register. This Section 8.7 shall be construed so that
the Obligations are at all times maintained in “registered form” within the meaning of Sections 163(f), 871(h)(2) and 881(c)(2) of the Code and any related regulations (and any other relevant or successor provisions of the Code or such
regulations). The register shall be available for inspection by any Purchaser from time to time upon reasonable prior notice. 
 8.8. Federal Income Tax Reporting. Notwithstanding anything to the contrary contained herein, each party hereto hereby acknowledges and agrees that for United States federal, state and local income
tax purposes, the aggregate “issue price” of the Notes under Section 1273(b) of the Code shall equal $25,000,000. Each party hereto agrees to use the foregoing issue price for all income tax, financial accounting and regulatory
purposes with respect to this transaction. Each party hereto further acknowledges and agrees that the Obligations shall be treated as debt for all tax and accounting purposes and no party shall take any position inconsistent therewith. 

ARTICLE 9 

MISCELLANEOUS 
 9.1. Survival. The representations, warranties and covenants contained herein shall survive the execution and delivery of this Agreement and the sale of the Securities. 

9.2. Indemnification. 

(a) Indemnification of Purchasers. The Company agrees to indemnify and hold harmless each Purchaser
and its affiliates and their respective directors, officers, trustees, members, managers, employees and agents, and their respective successors and assigns, from and against any and all losses, claims, damages, liabilities and expenses (including
without 

  
 21 

 
limitation reasonable attorney fees and disbursements and other expenses reasonably incurred in connection with investigating, preparing or defending any action, claim or proceeding, pending or
threatened and the costs of enforcement thereof) (collectively, “Losses”) to which such person or entity may become subject as a result of any breach of representation, warranty, covenant or agreement made by or to be performed on
the part of the Company under this Agreement, and will reimburse any such person or entity for all such amounts as they are incurred by such person or entity. 

(b) Conduct of Indemnification Proceedings. Any person or entity entitled to indemnification
hereunder shall (i) give prompt notice to the indemnifying party of any claim with respect to which it seeks indemnification and (ii) subject to the Company acknowledging in writing that such claim is an indemnifiable claim under this
Agreement, permit such indemnifying party to assume the defense of such claim with counsel reasonably satisfactory to the indemnified party; provided that any person entitled to indemnification hereunder shall have the right to employ
separate counsel and to participate in the defense of such claim, but the fees and expenses of such counsel shall be at the expense of such person unless (a) the indemnifying party has agreed to pay such fees or expenses, or (b) the
indemnifying party shall have failed to assume the defense of such claim and employ counsel reasonably satisfactory to such person or (c) in the reasonable judgment of any such person, based upon written advice of its counsel, a conflict of
interest exists between such person and the indemnifying party with respect to such claims (in which case, if the person notifies the indemnifying party in writing that such person elects to employ separate counsel at the expense of the indemnifying
party, the indemnifying party shall not have the right to assume the defense of such claim on behalf of such person); and provided, further, that the failure of any indemnified party to give notice as provided herein shall not relieve
the indemnifying party of its obligations hereunder, except to the extent that such failure to give notice shall materially adversely affect the indemnifying party in the defense of any such claim or litigation. It is understood that the
indemnifying party shall not, in connection with any proceeding in the same jurisdiction, be liable for fees or expenses of more than one separate firm of attorneys at any time for all such indemnified parties. No indemnifying party will, except
with the consent of the indemnified party, which consent shall not be unreasonably withheld, conditioned or delayed, consent to entry of any judgment or enter into any settlement that does not include as an unconditional term thereof the giving by
the claimant or plaintiff to such indemnified party of a release from all liability in respect of such claim or litigation. No indemnified party will, except with the consent of the indemnifying party, consent to entry of any judgment or enter into
any settlement. 
 9.3. Assignment; Successors and Assigns. This Agreement may not be assigned by either
party without the prior written consent of the other party; provided, that this Agreement may be assigned by any Purchaser to the valid transferee of any security purchased hereunder. This Agreement and all provisions thereof shall be binding
upon, inure to the benefit of, and are enforceable by the parties hereto and their respective successors and permitted assigns. 
 9.4. Notices. All notices, requests, and other communications hereunder shall be in writing and will be deemed to have been duly given and received (a) when personally delivered, (b) when
sent by facsimile upon confirmation of receipt, (c) one business day after the day on which the same has been delivered prepaid to a nationally recognized courier service, or (d) five business days after the deposit in the United States
mail, registered or certified, return receipt requested, postage prepaid, in each case 

  
 22 

 
addressed to Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, CA 94608, Attn: General Counsel, facsimile number: (510) 740-7416, with a copy to Fenwick & West LLP, 801
California Street, Mountain View, CA 94041, Attn: Dan Winnike, Esq., facsimile number: (650) 938-5200, and as to the Purchaser at the address and facsimile number set forth below the Purchaser’s signature on the signature pages of this
Agreement. Any party hereto from time to time may change its address, facsimile number, or other information for the purpose of notices to that party by giving notice specifying such change to the other parties hereto. Each Purchaser and the Company
may each agree in writing to accept notices and other communications to it hereunder by electronic communications pursuant to procedures reasonably approved by it; provided that approval of such procedures may be limited to particular notices or
communications. 
 9.5. Governing Law; Jurisdiction. 

(a) Governing Law. This Agreement, and the provisions, rights, obligations, and conditions set
forth herein, and the legal relations between the parties hereto, including all disputes and claims, whether arising in contract, tort, or under statute, shall be governed by and construed in accordance with the laws of the State of New York without
giving effect to its conflict of law provisions. 
 (b) Jurisdiction. Any and all disputes
arising out of, or in connection with, the interpretation, performance, or nonperformance of this Agreement or any and all disputes arising out of, or in connection with, transactions in any way related to this Agreement and/or the relationship
between the parties shall be litigated solely and exclusively before the United States District Court for the Southern District of New York. The parties consent to the in personam jurisdiction of said court for the purposes of any such litigation,
and waive, fully and completely, any right to dismiss and/or transfer any action pursuant to 28 U.S.C. § 1404 or 1406 (or any successor statute). In the event the United States District Court for the Southern District of New York does not have
subject matter jurisdiction of said matter, then such matter shall be litigated solely and exclusively before the appropriate state court of competent jurisdiction located in the state of New York. 

9.6. Severability. In the event that any provision of this Agreement or the application of any provision hereof is
declared to be illegal, invalid, or otherwise unenforceable by a court of competent jurisdiction, the remainder of this Agreement shall not be affected except to the extent necessary to delete such illegal, invalid, or unenforceable provision unless
that provision held invalid shall substantially impair the benefits of the remaining portions of this Agreement. 
 9.7. Headings. The headings in this Agreement are for convenience of reference only and shall not constitute a part of this Agreement, nor shall they affect its meaning, construction, or effect.

 9.8. Entire Agreement. This Agreement embodies the entire understanding and agreement between the
parties hereto with respect to the subject matter hereof and supersedes all prior agreements and understandings relating to the subject matter hereof. 
 9.9. Finder’s Fee. The Company agrees that it shall be responsible for the payment of any placement agent’s fees, financial advisory fees, or brokers’ commissions (other than for
persons engaged by Purchaser) relating to or arising out of the transactions contemplated hereby. The Company shall pay, 

  
 23 

 
and hold each Purchaser harmless against, any liability, loss or expense (including, without limitation, attorney’s fees and out-of-pocket expenses) arising in connection with any claim for
any such fees or commissions. 
 9.10. Expenses. Each party will bear its own costs and expenses in
connection with this Agreement; provided, however, the Company will pay at the Closing for the legal fees and expenses of Goodwin Procter LLP (“Goodwin”) incurred in connection with its role as counsel to the Purchasers in the
transactions contemplated by this Agreement up to a maximum of $35,000. The Company will make a payment of $35,000 to Goodwin at the Closing; provided that Goodwin will deliver within ten (10) business days thereafter a final invoice with
respect to Goodwin’s legal fees and expenses incurred in connection with its role as counsel to the Purchasers in the transactions contemplated by this Agreement (the “Final Legal Fee Amount”) and shall remit on such business
day to the Company by wire transfer of immediately available funds the amount, if any, by which the Final Legal Fee Amount is less than $35,000. 
 9.11. Further Assurances. The parties agree to execute and deliver all such further documents, agreements and instruments and take such other and further action as may be necessary or appropriate
to carry out the purposes and intent of this Agreement. 
 9.12. Counterparts. This Agreement may be
executed in two or more counterparts, each of which shall constitute an original, but all of which, when taken together, shall constitute but one instrument, and shall become effective when one or more counterparts have been signed by each party
hereto and delivered to the other party. Facsimile signatures shall be deemed originals for all purposes hereunder. 
 9.13. Independent Nature of Purchasers’ Obligations and Rights. The obligations of each Purchaser under this Agreement are several and not joint with obligations of each other Purchaser, and
no Purchaser shall be responsible in any way for the performance of the obligations of any other Purchaser under this Agreement or any other Transaction Agreements. The decision of each Purchaser to purchase Securities pursuant to this Agreement has
been made by such Purchaser independently of any other Purchaser and independently of any information, materials, statements or opinions as to the business, affairs, operations, assets, properties, liabilities, results of operations, condition
(financial or otherwise) or prospects of the Company or of the subsidiary which may have been made or given by any other Purchaser or by any agent or employee of any other Purchaser, and no Purchaser or any of its agents or employees shall have any
liability to any other Purchaser (or any other person) relating to or arising from any such information, materials, statements or opinions. Nothing contained herein or in any ancillary document, and no action taken by any Purchaser pursuant thereto,
shall be deemed to constitute the Purchasers as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that the Purchasers are in any way acting in concert or as a group with respect to such obligations
or the transactions contemplated by the Agreement. Each Purchaser acknowledges that no other Purchaser has or will be acting as agent of such Purchaser in enforcing its rights under this Agreement or any other Transaction Agreements. Each Purchaser
shall be entitled to independently protect and enforce its rights, including without limitation the rights arising out of this Purchaser, and it shall not be necessary for any other Purchaser to be joined as an additional party in any proceeding for
such purpose. 
 [Signature pages follows]

  
 24 

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Company as of February 24, 2012. 
  

			
	AMYRIS, INC.
		
	By:	 	 /s/ John Melo

	Name:	 	 John Melo

	Title:	 	 President and Chief Executive Officer

	
	PURCHASERS:
		
	By:	 	  

		 	(signature)
		
	 Name:
	 	  

		 	 (printed name)

		
	 Title:
	 	 Managing Member

 

			
	 Address:
	 	  

	
	  

	
	
 

 
			
	Facsimile No:	 	  

		
	E-mail Address:	 	  

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Purchasers as of the first date written above. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	
	
	PURCHASERS:
	
	 Fidelity Advisor Series I: Fidelity Advisor

	 Equity Income Fund

		
	 By:
	 	 /s/ Adrien Deberghes

		 	 (signature)

 

			
	 Name:
	 	 Adrien Deberghes

	 Title:
	 	 Deputy Treasurer

		
	 Address:
	 	 Andrew Boyd

		 	 Fidelity Investments

		 	 82 Devonshire St., VI3H

		 	 Boston, MA 02109

 

			
	 Tel:
	 	 (617) 563-5144

	 Fax:
	 	 (617) 385-2833

	 E-mail Address:
	 	 andrew.boyd@fmr.com

 [Signature Page to Securities Purchase Agreement] 

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Purchasers as of the first date written above. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	
	
	PURCHASERS:
	
	 Variable Insurance Products Fund: Equity

	 Income Portfolio

		
	 By:
	 	 /s/ Adrien Deberghes

		 	 (signature)

 

			
	 Name:
	 	 Adrien Deberghes

	 Title:
	 	 Deputy Treasurer

		
	 Address:
	 	 Andrew Boyd

		 	 Fidelity Investments

		 	 82 Devonshire St., VI3H

		 	 Boston, MA 02109

 

			
	 Tel:
	 	 (617) 563-5144

	 Fax:
	 	 (617) 385-2833

	 E-mail Address:
	 	 andrew.boyd@fmr.com

 [Signature Page to Securities Purchase Agreement] 

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Purchasers as of the first date written above. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	
	
	PURCHASERS:
	
	 Fidelity Devonshire Trust: Fidelity Equity

	 Income Fund

		
	 By:
	 	 /s/ Adrien Deberghes

		 	 (signature)

 

			
	 Name:
	 	 Adrien Deberghes

	 Title:
	 	 Deputy Treasurer

		
	 Address:
	 	 Andrew Boyd

		 	 Fidelity Investments

		 	 82 Devonshire St., VI3H

		 	 Boston, MA 02109

 

			
	 Tel:
	 	 (617) 563-5144

	 Fax:
	 	 (617) 385-2833

	 E-mail Address:
	 	 andrew.boyd@fmr.com

 [Signature Page to Securities Purchase Agreement] 

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Purchasers as of the first date written above. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	
	
	PURCHASERS:
	
	 Fidelity Destiny Portfolios: Fidelity

	 Advisor Diversified Stock Fund

		
	 By:
	 	 /s/ Adrien Deberghes

		 	 (signature)

 

			
	 Name:
	 	 Adrien Deberghes

	 Title:
	 	 Deputy Treasurer

		
	 Address:
	 	 Andrew Boyd

		 	 Fidelity Investments

		 	 82 Devonshire St., VI3H

		 	 Boston, MA 02109

 

			
	 Tel:
	 	 (617) 563-5144

	 Fax:
	 	 (617) 385-2833

	 E-mail Address:
	 	 andrew.boyd@fmr.com

 [Signature Page to Securities Purchase Agreement] 

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Purchasers as of the first date written above. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	
	
	PURCHASERS:
	
	 Variable Insurance Products Fund III:

	 Growth & Income Portfolio

		
	 By:
	 	 /s/ Adrien Deberghes

		 	 (signature)

 

			
	 Name:
	 	 Adrien Deberghes

	 Title:
	 	 Deputy Treasurer

		
	 Address:
	 	 Andrew Boyd

		 	 Fidelity Investments

		 	 82 Devonshire St., VI3H

		 	 Boston, MA 02109

 

			
	 Tel:
	 	 (617) 563-5144

	 Fax:
	 	 (617) 385-2833

	 E-mail Address:
	 	 andrew.boyd@fmr.com

 [Signature Page to Securities Purchase Agreement] 

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Purchasers as of the first date written above. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	
	
	PURCHASERS:
	
	 Fidelity Advisor Series I: Fidelity Advisor

	 Growth & Income Fund

		
	 By:
	 	 /s/ Adrien Deberghes

		 	 (signature)

 

			
	 Name:
	 	 Adrien Deberghes

	 Title:
	 	 Deputy Treasurer

		
	 Address:
	 	 Andrew Boyd

		 	 Fidelity Investments

		 	 82 Devonshire St., VI3H

		 	 Boston, MA 02109

 

			
	 Tel:
	 	 (617) 563-5144

	 Fax:
	 	 (617) 385-2833

	 E-mail Address:
	 	 andrew.boyd@fmr.com

 [Signature Page to Securities Purchase Agreement] 

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Purchasers as of the first date written above. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	
	
	PURCHASERS:
	
	 Fidelity Securities Fund: Fidelity Growth &

Income Portfolio

		
	 By:
	 	 /s/ Adrien Deberghes

		 	 (signature)

 

			
	 Name:
	 	 Adrien Deberghes

	 Title:
	 	 Deputy Treasurer

		
	 Address:
	 	 Andrew Boyd

		 	 Fidelity Investments

		 	 82 Devonshire St., VI3H

		 	 Boston, MA 02109

 

			
	 Tel:
	 	 (617) 563-5144

	 Fax:
	 	 (617) 385-2833

	 E-mail Address:
	 	 andrew.boyd@fmr.com

 [Signature Page to Securities Purchase Agreement] 

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Purchasers as of the first date written above. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	
	
	PURCHASERS:
	
	 Fidelity Commonwealth Trust: Fidelity

Large Cap Stock Fund

		
	 By:
	 	 /s/ Adrien Deberghes

		 	 (signature)

 

			
	 Name:
	 	 Adrien Deberghes

	 Title:
	 	 Deputy Treasurer

		
	 Address:
	 	 Andrew Boyd

		 	 Fidelity Investments

		 	 82 Devonshire St., VI3H

		 	 Boston, MA 02109

 

			
	 Tel:
	 	 (617) 563-5144

	 Fax:
	 	 (617) 385-2833

	 E-mail Address:
	 	 andrew.boyd@fmr.com

 [Signature Page to Securities Purchase Agreement] 

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Purchasers as of the first date written above. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	
	
	PURCHASERS:
	
	 Fidelity Advisor Series I: Fidelity Advisor

	 Large Cap Fund

		
	 By:
	 	 /s/ Adrien Deberghes

		 	 (signature)

 

			
	 Name:
	 	 Adrien Deberghes

	 Title:
	 	 Deputy
Treasurer

  

			
	 Address:
	 	 Andrew Boyd

		 	 Fidelity Investments

		 	 82 Devonshire St., VI3H

		 	 Boston, MA 02109

 

			
	 Tel:
	 	 (617) 563-5144

	 Fax:
	 	 (617) 385-2833

	 E-mail Address:
	 	 andrew.boyd@fmr.com

 [Signature Page to Securities Purchase Agreement] 

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Purchasers as of the first date written above. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	
	
	PURCHASERS:
	
	 Variable Insurance Products Fund III:

	 Balanced Portfolio

		
	 By:
	 	 /s/ Adrien Deberghes

		 	 (signature)

 

			
	 Name:
	 	 Adrien Deberghes

	 Title:
	 	 Deputy Treasurer

		
	 Address:
	 	 Andrew Boyd

		 	 Fidelity Investments

		 	 82 Devonshire St., VI3H

		 	 Boston, MA 02109

 

			
	 Tel:
	 	 (617) 563-5144

	 Fax:
	 	 (617) 385-2833

	 E-mail Address:
	 	 andrew.boyd@fmr.com

 [Signature Page to Securities Purchase Agreement] 

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Purchasers as of the first date written above. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	
	
	PURCHASERS:
	
	 Fidelity Advisor Series I: Fidelity Advisor

	 Dividend Growth Fund

		
	 By:
	 	 /s/ Adrien Deberghes

		 	 (signature)

 

			
	 Name:
	 	 Adrien Deberghes

	 Title:
	 	 Deputy Treasurer

		
	 Address:
	 	 Andrew Boyd

		 	 Fidelity Investments

		 	 82 Devonshire St., VI3H

		 	 Boston, MA 02109

 

			
	 Tel:
	 	 (617) 563-5144

	 Fax:
	 	 (617) 385-2833

	 E-mail Address:
	 	 andrew.boyd@fmr.com

 [Signature Page to Securities Purchase Agreement] 

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Purchasers as of the first date written above. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	
	
	PURCHASERS:
	
	 Fidelity Securities Fund: Fidelity Dividend

	 Growth Fund

		
	 By:
	 	 /s/ Adrien Deberghes

		 	 (signature)

 

			
	 Name:
	 	 Adrien Deberghes

	 Title:
	 	 Deputy Treasurer

		
	 Address:
	 	 Andrew Boyd

		 	 Fidelity Investments

		 	 82 Devonshire St., VI3H

		 	 Boston, MA 02109

 

			
	 Tel:
	 	 (617) 563-5144

	 Fax:
	 	 (617) 385-2833

	 E-mail Address:
	 	 andrew.boyd@fmr.com

 [Signature Page to Securities Purchase Agreement] 

 This Securities Purchase Agreement is hereby confirmed and accepted by the
Purchasers as of the first date written above. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	
	
	PURCHASERS:
	
	 Fidelity Rutland Square Trust II: Strategic

	 Advisers Core Multi-Manager Fund

		
	 By:
	 	 /s/ Adrien Deberghes

		 	 (signature)

 

			
	 Name:
	 	 Adrien Deberghes

	 Title:
	 	 Assistant Treasurer

		
	 Address:
	 	 Andrew Boyd

		 	 Fidelity Investments

		 	 82 Devonshire St., VI3H

		 	 Boston, MA 02109

 

			
	 Tel:
	 	 (617) 563-5144

	 Fax:
	 	 (617) 385-2833

	 E-mail Address:
	 	 andrew.boyd@fmr.com

 [Signature Page to Securities Purchase Agreement] 

 Schedule I 

Schedule of Purchasers 
  

									
	 Purchaser
	  	 Nominee Name
	  	 Physical Delivery Address
	  	Amount of
Security/Total
Purchase Price	 
	 Fidelity Advisor Series I: Fidelity
 Advisor Equity Income Fund
	  	 M Gardiner & Co fbo Fidelity

Advisor Series I: Fidelity
 Advisor Equity Income
Fund
	  	 JPMorgan Chase Bank, N.A.
 4 Chase Metrotech Center
 1st Floor, Window 5

Brooklyn, New York 11245-0001
 Attn: Physical Receive
 Department-Brian Cavanough

Internal a/c # P14381
	  	$	516,000	  
				
	 Variable Insurance Products Fund:
 Equity-Income Portfolio
	  	 Booth & Co fbo Variable Insurance
 Products Fund: Equity-Income
 Portfolio
	  	 The Northern Trust Company
 Attn: Trade Securities Processing,
 C-1N

801 South Canal Street
 Chicago, IL 60607
 Variable Insurance Products Fund: Equity-Income
Portfolio
 Internal a/c 26-67542
	  	$	1,383,000	  
				
	 Fidelity Devonshire Trust: Fidelity
 Equity-Income Fund
	  	 Booth & Co fbo Fidelity

Devonshire Trust: Fidelity
 Equity-Income
Fund
	  	 The Northern Trust Company
 Attn: Trade Securities Processing,
 C-1N

801 South Canal Street
 Chicago, IL 60607
 Fidelity Devonshire Trust:

Fidelity Equity-Income Fund
 Internal a/c 26-24993
	  	$	2,101,000	  
				
	 Fidelity Destiny Portfolios: Fidelity
 Advisor Diversified Stock Fund
	  	 Rowboat & Co fbo Fidelity Destiny
 Portfolios: Fidelity Advisor
 Diversified Stock Fund
	  	 DTCC/NY Window
 55 Water Street
 New York, NY 10041

SSB Internal Account #2441
 Attn: Robert Mendez
	  	$	2,000,000	  
				
	 Variable Insurance Products Fund III:
 Growth & Income Portfolio
	  	 M Gardiner & Co fbo Variable

Insurance Products Fund III:
 Growth & Income
Portfolio
	  	 JPMorgan Chase Bank, N.A.
 4 Chase Metrotech Center
 1st Floor, Window 5

Brooklyn, New York 11245-0001
 Attn: Physical Receive
 Department-Brian Cavanough

Internal a/c # P81587
	  	$	793,000	  
				
	 Fidelity Advisor Series I: Fidelity
 Advisor Growth & Income Fund
	  	 M Gardiner & Co fbo Fidelity

Advisor Series I: Fidelity
 Advisor Growth &
Income Fund
	  	 JPMorgan Chase Bank, N.A.
 4 Chase Metrotech Center
 1st Floor, Window 5

Brooklyn, New York 11245-0001
 Attn: Physical Receive
 Department-Brian Cavanough

Internal a/c # P81480
	  	$	1,592,000	  

									
	 Purchaser
	  	 Nominee Name
	  	 Physical Delivery Address
	  	Amount of
Security/Total
Purchase Price	 
	 Fidelity Securities Fund: Fidelity

Growth & Income Portfolio
	  	 Booth & Co fbo Fidelity Securities

Fund: Fidelity Growth & Income

Portfolio
	  	 The Northern Trust Company

Attn: Trade Securities Processing, C-1N
 801
South Canal Street
 Chicago, IL 60607

Variable Insurance Products Fund: Equity-Income Portfolio
 Internal a/c F40528
	  	$	5,615,000	  
				
	 Fidelity Commonwealth Trust: Fidelity

Large Cap Stock Fund
	  	 Mag & Co fbo Fidelity

Commonwealth Trust: Fidelity

Large Cap Stock Fund
	  	 Brown Brothers Harriman & Co

Attn: Trade Settlements New York- Bill Pinamonti
 140 Broadway
 New York, NY 10005-1101
 Fidelity Select Portfolios: Industrials
 Reference Internal Account # 8136152
	  	$	395,000	  
				
	 Fidelity Advisor Series I: Fidelity

Advisor Large Cap Fund
	  	 Mag & Co fbo Fidelity Advisor

Series I: Fidelity Advisor Large

Cap Fund
	  	 Brown Brothers Harriman & Co

Attn: Trade Settlements New York- Bill Pinamonti
 140 Broadway
 New York, NY 10005-1101
 Fidelity Select Portfolios: Industrials
 Reference Internal Account # 8136871
	  	$	605,000	  
				
	 Variable Insurance Products Fund III:

Balanced Portfolio
	  	 M Gardiner & Co fbo Variable

Insurance Products Fund III:

Balanced Portfolio
	  	 JPMorgan Chase Bank, N.A.
 4
Chase Metrotech Center
 1st Floor, Window 5
 Brooklyn, New York 11245-0001
 Attn: Physical Receive Department-Brian Cavanough

Internal a/c P 87349
	  	$	1,162,000	  
				
	 Fidelity Advisor Series I: Fidelity

Advisor Dividend Growth Fund
	  	 Enginebolt & Co fbo Fidelity

Advisor Series I: Fidelity Advisor

Dividend Growth Fund
	  	 DTCC/NY Window
 55 Water
Street
 New York, NY 10041
 SSB
Internal Account #24D1
 Attn: Robert Mendez
	  	$	791,000	  
				
	 Fidelity Securities Fund: Fidelity

Dividend Growth Fund
	  	 Ball & Co fbo Fidelity Securities

Fund: Fidelity Dividend Growth

Fund
	  	 Ball & Co
 C/o Citibank
N.A/Custody
 IC&D Lock Box
 P.O Box
7247-7057
 Philadelphia, P.A 19170-7057
	  	$	7,356,000	  

									
	 Purchaser
	  	 Nominee Name
	  	 Physical Delivery Address
	  	Amount of
Security/Total
Purchase Price	 
	 Fidelity Rutland Square Trust II:
 Strategic Advisers Core Multi-Manager Fund
	  	 Bost & Co fbo Fidelity Rutland

Square Trust II: Strategic

Advisers Core Multi-Manager

Fund
	  	 Mellon Securities Trust Co.

Bank of New York Mellon
 One Wall
Street
 Third Floor - Receive Window C

New York, NY 10286
 Reference Internal a/c #
FMRF2754602
	  	$	5,000	  
				
	 Fidelity Rutland Square Trust II:

Strategic Advisers Core Fund
	  	 Bost & Co fbo Fidelity Rutland

Square Trust II: Strategic

Advisers Core Fund
	  	 Mellon Securities Trust Co.

Bank of New York Mellon
 One Wall
Street
 Third Floor - Receive Window C

New York, NY 10286
 Reference Internal a/c #
FMRF2548402
	  	$	686,000	  
		  		  		  	  
	  
	 
				
	 TOTAL
	  		  		  	$	25,000,000	  
		  		  		  	  
	  
	 

 Exhibit A 

FORM OF SECURITY 

 Exhibit B 

RIGHTS AGREEMENT 

 Exhibit C 

Opinion of Company CounselForm of Unsecured Senior Convertible Promissory Note

 Exhibit 4.03 
 SENIOR UNSECURED CONVERTIBLE NOTE 
  

			
	
          U.S.$             
   
	  	February 27, 2012

					
		
	 THE SECURITIES REPRESENTED BY THIS NOTE AND THE SECURITIES ISSUABLE UPON ITS CONVERSION HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR SECURITIES LAWS OF ANY STATE AND MAY NOT BE OFFERED, SOLD, ASSIGNED, PLEDGED TRANSFERRED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT AND
APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN AVAILABLE EXEMPTION FROM REGISTRATION UNDER THE ACT OR SUCH LAWS AND, IF REASONABLY REQUESTED BY THE COMPANY, UPON DELIVERY OF AN OPINION OF COUNSEL REASONABLY SATISFACTORY TO THE COMPANY THAT THE
PROPOSED TRANSFER IS EXEMPT FROM THE ACT OR SUCH LAWS. THIS NOTE IS ALSO SUBJECT TO THE TRANSFER RESTRICTIONS CONTAINED IN THE SECURITIES PURCHASE AGREEMENT, DATED AS OF FEBRUARY 24, 2012, AMONG THE COMPANY AND THE PURCHASERS NAMED
THEREIN.
	  	

 FOR VALUE RECEIVED, the undersigned, Amyris, Inc., a Delaware corporation (the
“Company”), promises to pay to [Nominee name; see spreadsheet], or its assigns (the “Investor”), in lawful money of the United States and in immediately available funds (or in shares of Common Stock as
provided in Section 2(b)), U.S. $[    ] (the “Face Amount”), all in accordance with the provisions of this Note. The “Issue Date” of this Note is February 27, 2012. 

This Note was issued pursuant to the Securities Purchase Agreement, dated as of February 24, 2012 (as amended from
time to time, the “Agreement”), among the Company and the other parties thereto. Unless the context otherwise requires, as used herein, “Note” means any of the Convertible Notes issued pursuant to the
Agreement and any other similar convertible notes issued by the Company in exchange for, or to effect a transfer of, any Note and “Notes” means all such Notes in the aggregate. 

1. Definitions. For purposes of this Note, the following definitions shall be applicable: 

“Affiliate” of any specified person means any other person directly or indirectly controlling or
controlled by or under direct or indirect common control with such specified person; for purposes of this definition, “control” (including, with correlative meanings, the terms “controlling,” “controlled by” and
‘under common control with”), as used with respect to any person, shall mean the possession, directly or indirectly, of the power to direct or cause the direction of the management or policies of such person, whether through the ownership
of voting securities, by agreement or otherwise. 
 “Bankruptcy Law” means
Title 11, U.S. Code or any similar federal or state law for the relief of debtors. 

 “Board of Directors” means the board of directors of
the Company. 
 “Business Day” means any day other than a Saturday, a Sunday or a day on
which the Federal Reserve Bank of New York is authorized or required by law or executive order to close or be closed. 
 “Capital Lease Obligation” means, at the time any determination thereof is to be made, the amount of the liability in respect of a capital lease that would at such time be required
to be capitalized on a balance sheet in accordance with GAAP. 
 “Certificate of
Incorporation” means the Company’s Restated Certificate of Incorporation, as amended and as in effect on the date hereof. 
 “Change of Control” shall mean the occurrence of any of the following: (i) the consolidation of the Company with, or the merger of the Company with or into, another
“person” (as such term is used in Rule 13d-3 and Rule 13d-5 of the Exchange Act), or the sale, lease, transfer, conveyance or other disposition, in one or a series of related transactions, of all or substantially all of the assets of the
Company and its Subsidiaries taken as a whole, or the consolidation of another “person” with, or the merger of another “person” into, the Company, other than in each case pursuant to a transaction in which the “persons”
that “beneficially owned” (as such term is defined in Rule 13d-3 and Rule 13d-5 under the Exchange Act), directly or indirectly, the Voting Shares of the Company immediately prior to the transaction “beneficially own”, directly
or indirectly, Voting Shares representing at least a majority of the total voting power of all outstanding classes of voting stock of the surviving or transferee person; (ii) the adoption by the Company of a plan relating to the liquidation or
dissolution of the Company; (iii) the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any “person” becomes the “beneficial owner” directly or
indirectly, of more than 50% of the Voting Shares of the Company (measured by voting power rather than number of shares); or (iv) the first day on which a majority of the members of the Board of Directors does not consist of Continuing
Directors. 
 “Closing Price” of the shares of Common Stock on any day means the last
reported sale price regular way on such day or, in the case no such sale takes place on such day, the average of the reported closing bid and asked prices regular way of the shares of Common Stock, in each case as quoted on The NASDAQ Stock Market
or such other principal securities exchange or inter-dealer quotation system on which the shares of Common Stock are then traded. 
 “Common Stock” means the Company’s common stock, $0.0001 par value per share (or such other security into which such Common Stock is exchanged for (or becomes) pursuant to the
consummation of a Capital Reorganization). 
 “Continuing Director” shall mean, as of
any date of determination, any member of the Board of Directors who (i) was a member of the Board of Directors on the Issue Date or was appointed pursuant to the Agreement or (ii) was nominated for election or elected to the Board of
Directors with the approval of a majority of the Continuing Directors who were members of the Board of Directors at the time of such nomination or election and who voted with respect to such 

  
 2 

 
nomination or election; provided that a majority of the members of the Board of Directors voting with respect thereto shall at the time have been Continuing Directors. 

“Debt” shall mean, with respect to any person, any indebtedness of such person, whether or not
contingent, in respect of borrowed money or evidenced by bonds, notes, debentures or similar instruments or letters of credit (or reimbursement agreements in respect thereof) or banker’s acceptances or representing Capital Lease Obligations or
the balance deferred and unpaid of the purchase price of any property or representing any Hedging Obligations, except any such balance that constitutes an accrued expense or trade payable, if and to the extent any of the foregoing indebtedness
(other than letters of credit and Hedging Obligations) would appear as a liability upon a balance sheet of such Person prepared in accordance with GAAP, as well as all Debt of others secured by a Lien on any asset of such Person (whether or not such
Debt is assumed by such Person) and Lease Debt and, to the extent not otherwise included, the Guarantee by such Person of any Debt of any other Person. The amount of any Debt outstanding as of any date shall be (i) the accreted value thereof,
in the case of any Debt that does not require current payments of interest or (ii) the principal amount thereof, together with any interest thereon that is more than 30 days past due, in the case of any other Debt. 

“Default” means any event that is or with the passage of time or the giving of notice or both
would be an Event of Default. 
 “Disqualified Stock” means any capital stock that, by
its terms (or by the terms of any security into which it is convertible, or for which it is exchangeable, in each case, at the option of the holder of the capital stock), or upon the happening of any event, matures or is mandatorily redeemable,
pursuant to a sinking fund obligation or otherwise, or redeemable at the option of the holder of the capital stock, in whole or in part, on or prior to the date that is 91 days after the date on which the Notes mature. The amount of Disqualified
Stock deemed to be outstanding at any time will be the maximum amount that the Company and its Subsidiaries may become obligated to pay upon the maturity of, or pursuant to any mandatory redemption provisions of, such Disqualified Stock, exclusive
of accrued dividends. 
 “Exchange Act” means the Securities Exchange Act of 1934, as
amended. 
 “GAAP” means generally accepted accounting principles set forth in the
opinions and pronouncements of the Accounting Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards Board or in such other statements by such other entity
as have been approved by a significant segment of the accounting profession in the United States, which are in effect from time to time. 
 “Guarantee” means a guarantee (other than by endorsement of negotiable instruments for collection in the ordinary course of business), direct or indirect, in any manner (including,
without limitation, by way of a pledge of assets, letters of credit and reimbursement agreements in respect thereof), of all or any part of any Debt. 
 “Hedging Obligations” means, with respect to any person, the obligations of such person under (i) currency exchange or interest rate swap agreements, interest rate cap
agreements and 

  
 3 

 
interest rate collar agreements and (ii) other agreements or arrangements designed to protect such person against fluctuations in interest rates or currency exchange rates. 

“Holder” means the Person in whose name this Note is registered in the Company’s Note
Register and “Holders” means, collectively, the Persons in whose names all the Notes are registered in the Company’s Note Register. 

“Lease Debt” means, with respect to any Person, (i) the amount of any accrued and unpaid
obligations of such Person arising under any lease or related document (including a purchase agreement, conditional sale or other title retention agreement) in connection with the lease of real property or improvement thereon (or any personal
property included as part of any such lease) which provides that such Person is contractually obligated to purchase or cause a third party to purchase the leased property or pay an agreed upon residual value of the leased property to the lessor
(whether or not such lease transaction is characterized as an operating lease or a capitalized lease in accordance with GAAP) and (ii) the guarantee, direct or indirect, in any manner (including, without limitation, letters of credit and
reimbursement agreements in respect thereof), of any of the amounts set forth in (i) above. 

“Lien” means, with respect to any asset, any mortgage, lien, pledge, charge, security interest or
encumbrance of any kind in respect of such asset, whether or not filed, recorded or otherwise perfected under applicable law (including any conditional sale or other title retention agreement, any lease in the nature thereof, any option or other
agreement to sell or give a security interest in and any filing of or agreement to give any financing statement under the Uniform Commercial Code (or equivalent statutes) of any jurisdiction). 

“Person” means any individual, corporation, limited liability company, partnership, joint
venture, association, joint-stock company, trust, unincorporated organization or government or any agency or political subdivision thereof. 
 “Registration Rights Agreement” means that certain Registration Rights Agreement, dated February 24, 2012, by and among the Company and the Holders. 

“Securities Act” means the Securities Act of 1933, as amended. 

“Subsidiary” means, with respect to any specified Person: 

(1) any corporation, association or other business entity of which more than 50% of the total voting power of shares of
capital stock entitled (without regard to the occurrence of any contingency and after giving effect to any voting agreement or stockholders’ agreement that effectively transfers voting power) to vote in the election of directors, managers or
trustees of the corporation, association or other business entity is at the time owned or controlled, directly or indirectly, by that Person or one or more of the other Subsidiaries of that Person (or a combination thereof); and 

(2) any partnership (a) the sole general partner or the managing general partner of which is such Person or a
Subsidiary of such Person or (b) the only general partners of which are that Person or one or more Subsidiaries of that Person (or any combination thereof). 

  
 4 

 “Trading Day” means, with respect to the Common
Stock, each Monday, Tuesday, Wednesday, Thursday and Friday, other than any day on which securities are not generally traded on The NASDAQ Stock Market (or its successor) or such other principal securities exchange or inter-dealer quotation system
on which the shares of Common Stock are then traded. 
 “Voting Shares” of any person
means capital shares or capital stock of such Person which ordinarily has voting power for the election of directors (or persons performing similar functions) of such person, whether at all times or only so long as no senior class of securities has
such voting power by reason of any contingency. 
 2. Interest; Payment of Principal of Note.

 (a) Interest. This Note shall bear interest on the Face Amount at a rate per annum equal to 3.00%
(subject to Section 5(c)). Interest on this Note shall accrue daily and be due and payable in arrears on each six-month anniversary of the Issue Date and at such other times as may be specified herein. All computations of interest shall be made
on the basis of a 360-day year and actual days elapsed (which results in more interest being paid than if computed on the basis of a 365-day year). Notwithstanding the foregoing, if an Event of Default shall have occurred and be continuing, this
Note shall bear interest on the Face Amount at a rate per annum equal to 5.00% (as may be further adjusted pursuant to Section 5(c)). 
 (b) Scheduled Payment of Principal. Unless paid earlier in accordance with the terms hereof, the Company shall deliver to the Holder of this Note cash in the amount of the Face Amount on
March 1, 2017 (the “Final Maturity Date”). 
 (c) Pro Rata Payment. The
Company agrees that any payments to the Holders of the Notes (including, without limitation, upon acceleration pursuant to Section 5) shall be made pro rata among all such Holders based upon the aggregate principal amount of the Notes held by
each such Holder. If any Holder of a Note obtains any payment (whether voluntary, involuntary, by application of offset or otherwise) on such Note in excess of such Holder’s pro rata share of payments obtained by all Holders of the Notes, such
Holder shall make payments to the other Holders of the Notes based on such participation in the Notes held by them as is necessary to cause such Holders to share the excess payment ratably among each of them as provided in this Section 2(c).

 3. Conversion Rights; Adjustments. The Holders of the Notes shall have conversion rights as follows
(the “Conversion Rights”): 
 (a) Holder’s Right to Convert. At any time
after the date hereof and prior and to the fifth Trading Day prior to the Final Maturity Date, the Holder shall have the right to convert the Face Amount of this Note, in whole or in part, at the option of the Holder thereof, at any time within the
period specified above and from time to time into a number of fully paid and nonassessable authorized but unissued Common Stock determined by dividing (x) the Face Amount proposed to be converted at such date by (y) the then effective
Conversion Price on the Conversion Date (as defined below) (each such conversion, a “Holder’s Optional Conversion”). 

  
 5 

 (b) The “Conversion Price” at which Common Stock shall be
deliverable upon conversion of the Notes (the “Conversion Price”) shall initially be $ 7.0682. Such initial Conversion Price shall be subject to adjustment as provided below. 

(c) Mechanics of Conversion. 

(i) In order to exercise its rights pursuant to a Holder’s Optional Conversion, the Holder shall deliver written
notice in the form of Exhibit 1 to the Company stating that such Holder elects to convert all or part of the Face Amount represented by this Note. Such notice shall state the Face Amount of Notes which the Holder seeks to convert and shall be
accompanied within one (1) Trading Day by the Note or Notes subject to conversion. The date contained in the notice (which date shall be no earlier than the Trading Day immediately following the date of the notice) shall be the date of
conversion of the Note (such date of conversion, the “Conversion Date”) and the Holder shall be deemed to be the beneficial owner of the underlying Common Stock as of such date. 

(ii) The Holder of this Note shall be deemed to beneficially own the Common Stock underlying this Note as of the
applicable Conversion Date. Not later than three (3) Trading Days following the Conversion Date, the Company shall promptly issue and deliver to each Holder a certificate or certificates for the number of shares of Common Stock to which such
Holder is entitled and, in the case where only part of a Note is converted, the Company shall execute and deliver (at its own expense) a new Note of any authorized denomination as requested by a Holder in an aggregate principal amount equal to and
in exchange for the unconverted portion of the principal amount of the Note so surrendered. In lieu of delivering physical certificates representing the shares of Common Stock issuable upon conversion of Notes, provided the Company’s transfer
agent is participating in the Depository Trust Company (“DTC”) Fast Automated Securities Transfer program, upon request of the Holder, the Company may, at its election (and shall, if practicable and upon the reasonable
request of any Holder after the date six months after the initial issuance of this Note, and if the Holder is not an “affiliate” of the Company (as defined under the Securities Act of 1933, as amended), cause its transfer agent to
electronically transmit the shares of Common Stock issuable upon conversion of this Note to the Holder, by crediting the account of Holder’s prime broker with DTC through its Deposit Withdrawal Agent Commission (“DWAC”)
system, if such DWAC system is available for the issuance of such shares of Common Stock under the terms of this Note and the Agreement. The time periods for delivery described above shall apply to the electronic transmittals through the DWAC
system. The parties agree to coordinate with DTC to accomplish this objective. The conversions pursuant to Section 3 shall be deemed to have been made immediately prior to the opening of business on the applicable Conversion Date. The person or
persons entitled to receive the shares of Common Stock issuable upon such conversion shall be treated as the beneficial owner of such shares of Common Stock at the opening of business on the applicable Conversion Date 

(iii) Upon conversion of this Note in whole or in part, the Company shall pay to the Holder, substantially concurrently
with delivery of the shares of Common Stock issuable on such conversion, any accrued and unpaid interest, through the day preceding the Conversion Date, on the portion of the Face Amount represented by this Note that has been so converted. In
addition, upon conversion of this Note in whole or in part following a Change of 

  
 6 

 
Control, the Company shall pay to the Holder, substantially concurrently with delivery of the shares of Common Stock issuable upon such conversion, an amount in cash equal to the interest that
would have accrued from such Conversion Date through the Final Maturity Date on the portion of the Face Amount represented by this Note that has been so converted if such Note (or portion of the Note) had not been converted (“Make-Whole
Interest”). 
 (iv) The Company shall at all times during which the Notes shall be outstanding, have and
keep available out of its authorized but unissued shares, for the purpose of effecting the conversion of the Notes, such number of its duly authorized shares of Common Stock as shall from time to time be sufficient to effect the conversion of all
outstanding Notes. In no event shall the Conversion Price be reduced to an amount less than the then par value of the Common Stock. 
 (v) No fractional shares of Common Stock shall be issued upon any conversion of the Notes pursuant to this Section 3. In lieu of fractional shares, the Company shall pay cash equal to such fraction
multiplied by the Closing Price of the Common Stock on the Conversion Date. 
 (vi) All Notes (or the portions
thereof) which shall have been surrendered for conversion as herein provided shall no longer be deemed to be outstanding and all rights with respect to such Notes, except only the right of the Holders thereof to receive shares of Common Stock in
exchange therefor, accrued and unpaid interest and Make-Whole Interest, if applicable, each as described in Section 3(b)(iii) and, if applicable, cash for any fractional shares of Common Stock. Any Notes, to the extent so converted, shall be
retired and canceled. 
 (vii) If any conversion pursuant to this Section 3 is in connection with an
underwritten offering of securities registered pursuant to the Securities Act, the conversion may, at the option of any Holder tendering Notes for conversion, be conditioned upon the closing with the underwriter of the sale of the shares of Common
Stock issuable to such Holder in connection with such conversion pursuant to such offering, in which event the Holders entitled to receive the shares of Common Stock issuable upon such conversion of the Notes shall not be deemed to have converted
such Notes until immediately prior to the closing of the sale of securities. 
 (d) Adjustment for Share
Splits and Combinations. If the Company shall at any time or from time to time after the Issue Date effect a subdivision of the outstanding shares of Common Stock, the Conversion Price and Conversion Price Floor (as defined in Section 3(e))
then in effect immediately before that subdivision shall be proportionately decreased. If the Company shall at any time or from time to time after the Issue Date combine the outstanding shares of Common Stock, the Conversion Price and Conversion
Price Floor then in effect immediately before the combination shall be proportionately increased. Any adjustment under this paragraph shall become effective at the close of business on the date the subdivision or combination becomes effective.

 (e) Adjustment for Certain Dividends and Distributions. In the event the Company at any time or from
time to time after the Issue Date shall make or issue a dividend or 

  
 7 

 
other distribution payable in (x) additional shares of Common Stock, then and in each such event the Conversion Price shall be decreased as of the time of such issuance, by multiplying such
Conversion Price by a fraction, the numerator of which shall be the total number of shares of Common Stock outstanding immediately prior to such issuance and the denominator of which shall be the total number of shares of Common Stock outstanding
immediately prior to such issuance plus the number of such additional shares of Common Stock issuable in payment of such dividend or distribution; (y) in cash, then and in each such event, the Conversion Price shall be decreased as of the time
of such issuance, by multiplying such Conversion Price by a fraction, the numerator of which shall be the Closing Price of the Common Stock on the Trading Day immediately preceding the ex-dividend date for such dividend and distribution minus the
amount in cash per share of Common Stock that the Company dividends or distributes, and the denominator of which shall be the Closing Price of the Common Stock on the Trading Day immediately preceding the ex-dividend date for such dividend and
distribution; (z) shares of capital stock of the Company, evidences of indebtedness, or any other asset (collectively, the “Distributed Property”), then and in each such event, the Conversion Price shall be decreased as of the
time of such issuance, by multiplying such Conversion Price by a fraction, the numerator of which shall be the Closing Price of the Common Stock on the Trading Day immediately preceding the ex-dividend date for such dividend and distribution minus
the fair market value (as determined in good faith by the Company’s board of directors) of the Distributed Property distributed with respect to each share of Common Stock, and the denominator of which shall be the Closing Price of the Common
Stock on the Trading Day immediately preceding the ex-dividend date for such dividend and distribution. Notwithstanding the foregoing, in no event shall the Conversion Price be reduced below $5.99 (as may be adjusted pursuant to Section 3(d),
the “Conversion Price Floor”) pursuant to this clause (e). If a distribution or dividend would cause the Conversion Price to be below the Conversion Price Floor if not for the immediately preceding sentence, the Company shall
allow the Holder to participate in the dividend or distribution as if it held the number of shares of Common Stock that this Note would be convertible into at the close of business on the day immediately preceding the ex-dividend date or effective
date, as the case may be, for such distribution or dividend, and no adjustment shall be made to the Conversion Price as a result of such distribution or dividend. 

(f) Adjustment for Reclassification, Exchange or Substitution. If the shares of Common Stock issuable upon the
conversion of the Notes shall be changed into the same or a different number of shares of any class or classes of shares, whether by capital reorganization, reclassification, or otherwise (other than a subdivision or combination of shares, share
dividend or reorganization, reclassification, merger, consolidation or asset sale provided for elsewhere in this Section 3), then and in each such event the Holder of each Note (whether then outstanding or thereafter issued) shall have the
right thereafter to convert such Note into the kind and amount of shares and other securities and property receivable upon such reorganization, reclassification, or other change, by holders of the number of shares of Common Stock into which all such
Notes might have been converted immediately prior to such reorganization, reclassification, or change, all subject to further adjustment as provided herein or with respect to such other securities or property by the terms thereof. 

(g) Reorganizations, Mergers, Consolidations or Asset Sales. If at any time after the Issue Date there is a tender
offer, exchange offer, merger, consolidation, 

  
 8 

 
recapitalization, sale of all or substantially all of the Company’s assets or reorganization involving the shares of Common Stock (collectively, a “Capital
Reorganization”) (other than a merger, consolidation, sale of assets, recapitalization, subdivision, combination, reclassification, exchange or substitution of shares provided for elsewhere in this Section 3), as part of such
Capital Reorganization, provision shall be made so that the Holders of Notes will thereafter be entitled to receive upon conversion of the Notes the number of shares or other securities or property of the Company to which a holder of the number of
shares of Common Stock deliverable upon conversion immediately prior to such Capital Reorganization would have been entitled on such Capital Reorganization, subject to adjustment in respect to such shares or securities by the terms thereof. In any
such case, appropriate adjustment will be made in the application of the provisions of this Section 3 with respect to the rights of the Holders of Notes after the Capital Reorganization to the end that the provisions of this Section 3
(including adjustment of the Conversion Price then in effect and the number of shares issuable upon conversion of the Notes) and the provisions of the Agreement and the Registration Rights Agreement will be applicable after that event and be as
nearly equivalent as practicable. In the event that the Company is not the surviving entity of any such Capital Reorganization, each Note shall become Notes of such surviving entity, with the same powers, rights and preferences as provided herein.

 (h) No Impairment. The Company will not, by amendment of its Certificate of Incorporation or through
any reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms to be observed or performed hereunder by
the Company, but will at all times in good faith assist in the carrying out of all the provisions of this Section 3 and in the taking of all such action as may be necessary or appropriate in order to protect the conversion rights of the Holders
of the Notes against impairment to the extent required hereunder. 
 (i) Certificate as to Adjustments or
Distributions. Upon the occurrence of each adjustment of the Conversion Price or distribution to holders pursuant to this Section 3, the Company at its expense shall promptly compute such adjustment or distribution in accordance with the
terms hereof and furnish to each Holder, if any, of Notes outstanding a certificate setting forth the terms of such adjustment or distribution and showing in detail the facts upon which such adjustment or distribution are based and shall file a copy
of such certificate with its corporate records. 
 (j) Notice of Record Date. In the event: 

(i) that the Company declares a dividend (or any other distribution) on its Common Stock payable in shares of Common
Stock, securities, or other assets, rights or properties; 
 (ii) that the Company subdivides or combines its
outstanding shares of Common Stock; 

  
 9 

 (iii) of any reclassification of the shares of Common Stock (other than a
subdivision or combination of the Company’s outstanding shares of Common Stock or a share dividend or share distribution thereon); 
 (iv) of any Capital Reorganization; or 
 (v) of the involuntary
or voluntary dissolution, liquidation or winding up of the Company; 
 then the Company shall cause to be filed at its principal
office, and shall cause to be mailed to the Holders of the Notes at their last addresses as shown on the records of the Company, at least ten (10) days prior to the record date specified in (A) below or twenty (20) days prior to the
date specified in (B) below, a notice stating: 
 (A) the record date of such dividend, distribution,
subdivision or combination, or, if a record is not to be taken, the date as of which the holders of shares of Common Stock of record to be entitled to such dividend, distribution, subdivision or combination are to be determined, or 

(B) the date on which such reclassification, Capital Reorganization, dissolution, liquidation or winding up is expected
to become effective, and the date as of which it is expected that holders of shares of Common Stock of record shall be entitled to exchange their shares of Common Stock for securities or other property deliverable upon such reclassification, Capital
Reorganization, dissolution or winding up 
 (k) Notice of Adjustment to Conversion Price. The Company
will provide notice to each Holder upon the occurrence of any adjustment to the Conversion Price. 
 4.
Repurchase Right Upon a Change of Control. 
 (a) Upon the occurrence of a Change of Control, each
Holder of Notes will have the right to require the Company to repurchase all or any part of its Notes pursuant to an offer as provided in this Section 4 (the “Change of Control Offer”) at an offer price in cash equal to
101% of the Face Amount of its Notes, plus any accrued and unpaid interest as of the Change of Control Payment Date (as defined in Section 4(b)(i)) (the “Change of Control Payment”). 

(b) On or before the 30th day after a Change of Control, the Company shall give to all Holders of Notes notice (the
“Change of Control Notice”) of the occurrence of the Change of Control and of the Holder’s right to receive the Change of Control Payment arising as a result thereof. Each notice of the Holder’s right to participate
in the Change of Control Offer (the “Change of Control Repurchase Right”) shall be mailed to the Holders of the Notes at their last address as shown in the Note Register and shall state: 

(i) the date on which the Notes shall be repurchased (the “Change of Control Payment Date”),
which date shall be no earlier than 30 days and no later than 60 days from the date of the Company’s delivery of the Change of Control Notice; 

  
 10 

 (ii) the date by which the Change of Control Repurchase Right must be
exercised, which date shall be no earlier than the close of business on the Trading Day immediately prior to the Change of Control Payment Date; 
 (iii) the amount of the Change of Control Payment; 
 (iv) a
description of the procedure which a Holder must follow to exercise the Change of Control Repurchase Right, and the place or places where the Notes are to be surrendered for payment of the Change of Control Payment; and 

(v) the Conversion Price then in effect and the place where such Notes may be surrendered for conversion. 

No failure by the Company to give the Change of Control Notice and no defect in any Change of Control Notice shall limit
any Holder’s right to exercise its Change of Control Repurchase Right or affect the validity of the proceedings for the repurchase of Notes. 
 If any of the foregoing provisions or other provisions of this Section 4 are inconsistent with applicable law, such law shall govern. 

(c) To exercise the Change of Control Repurchase Right, a Holder shall deliver to the Company, on or before the Trading
Day immediately prior to the Change of Control Payment Date, (i) written notice of the Holder’s exercise of such right, which notice shall set forth the name of the Holder, the Face Amount of Notes held by such Holder to be repurchased,
and a statement that an election to exercise the Change of Control Repurchase Right is being made thereby, and (ii) the Notes with respect to which the Change of Control Repurchase Right is being exercised. Such written notice shall be
irrevocable, except that the right of the Holder to convert the Notes shall continue until midnight (Eastern Time) on the Trading Day immediately preceding the Change of Control Repurchase Date. 

(d) On the Change of Control Payment Date, the Company will (i) accept for payment all Notes or portions thereof
properly tendered pursuant to the Change of Control Offer and (ii) deliver cash in the amount of the Change of Control Payment to each Holder in respect of all Notes or portions thereof so tendered. All Notes repurchased by the Company shall be
canceled immediately by the Company 
 (e) The Company shall publicly announce the results of the Change of
Control Offer on or as soon as practicable after the Change of Control Payment Date. 
 (f) The Company will
comply with the requirements of Rule 14e-1 under the Exchange Act and any other securities laws and regulations thereunder to the extent such laws and regulations are applicable in connection with the repurchase of the Notes as a result of a Change
of Control. 
 (g) Any Note which is to be repurchased only in part shall be surrendered to the Company and the
Company shall execute and make available for delivery to the Holder of such Note without service charge, a new Note or Notes, containing identical terms and conditions, each in an authorized denomination in aggregate principal amount equal to and in

  
 11 

 
exchange for the unrepurchased portion of the principal of the Note so surrendered. Any Notes surrendered to the Company pursuant to the provisions of this Section 4 shall be retired and
cancelled. 
 (h) The Company will not be required to make a Change of Control Offer upon a Change of Control if
a third party makes the Change of Control Offer in the manner, at the times and otherwise in compliance with the requirements set forth in this Section 4 applicable to a Change of Control Offer made by the Company and purchases all Notes
validly tendered and not withdrawn under such Change of Control Offer. 
 5. Events of Default.

 (a) Definitions. For purposes of this Note, the following events shall constitute an “Event
of Default”: 
 (i) default in payment when due (whether at the Final Maturity Date or upon an
earlier repurchase) of the principal of, or premium, if any, on this Note; 
 (ii) default in the payment of an
installment of interest on the Notes, which failure continues for thirty (30) days after the date when due; 
 (iii) failure by the Company for thirty (30) days after notice from the Holders of at least 50% in principal amount of the then outstanding Notes to comply with the provisions of Section 4 or
Section 6 of this Note; 
 (iv) failure by the Company for sixty (60) days after notice from the
Holders of at least 50% in principal amount of the then outstanding Notes to comply with any of its other agreements in this Note or the Agreement (other than Section 8.6(a) of the Agreement); 

(v) default under any mortgage, indenture or instrument under which there may be issued or by which there may be secured
or evidenced any Debt for money borrowed by the Company (or the payment of which is guaranteed by the Company, whether such Debt or guarantee now exists, or is created after the date of the Issue Date, which default (a) is caused by a failure
to pay principal of or premium, if any, or interest on such Debt prior to the expiration of the grace period provided in such Debt on the date of such default or (b) results in the acceleration of such Debt prior to its express maturity and, in
each case in clause (a) or (b), the principal amount of any such Debt, together with the principal amount of any other such Debt that has not been paid when due, or the maturity of which has been so accelerated, aggregates $10,000,000 or more;

 (vi) failure by the Company to pay final judgments aggregating in excess of $10,000,000, which judgments are
not paid, discharged or stayed for a period of sixty (60) days; 
 (vii) the Company: 

(A) commences a voluntary case under any Bankruptcy Law, 

(B) consents to the entry of an order for relief against it in an involuntary case under any Bankruptcy Law, 

  
 12 

 (C) consents to the appointment of a custodian of it or for all or
substantially all of its property, 
 (D) makes a general assignment for the benefit of its creditors, or

 (E) is unable to pay its debts as they become due; or 

(viii) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that: 

(A) is for relief against the Company; 

(B) appoints a custodian of the Company or any of its Significant Subsidiaries or for all or substantially all of the
property of the Company; or 
 (C) orders the liquidation of the Company; and the order or decree remains
unstayed and in effect for sixty (60) consecutive days; or 
 (ix) failure by the Company to deliver when
due the consideration deliverable upon conversion of this Note, which failure shall continue for a period of five days. 
 (b) Notice of Compliance. The Company shall be required to deliver to the Holders annually a statement regarding compliance with this Note, and the Company shall be required within thirty
(30) days of becoming aware of any Default or Event of Default to deliver to the Holders a statement specifying such Default or Event of Default. 
 (c) Acceleration. If any Event of Default occurs and is continuing, the Holders of at least 50% in principal amount of the then outstanding Notes may declare all the Notes to be due and payable
immediately. Notwithstanding the foregoing, in the case of an Event of Default described in Section 5(vii) or (viii) with respect to the Company all outstanding Notes will become due and payable without further action or notice. The
Holders of a majority in aggregate principal amount of the then outstanding Notes may on behalf of all of the Holders rescind an acceleration and its consequences if the rescission would not conflict with any judgment or decree and if all existing
Events of Default (except nonpayment of principal that has become due solely because of the acceleration) have been cured or waived. Notwithstanding the foregoing (or anything to the contrary in the Agreement), the sole remedy of the Holders for a
failure by the Company to comply with Section 8.6 of the Agreement shall, for the first 365 days after the occurrence of such failure, be the right, by notice to the Company by holders of a majority in aggregate principal amount of the Notes
then outstanding, to increase in the rate of interest on this Note to 6% for the first 180 days of such failure, and to 9% thereafter (which increased interest shall constitute liquidated damages for such failure). 

(d) Waiver of Past Defaults. The Holders of a majority in aggregate principal amount of the Notes then outstanding
may, on behalf of the Holders of all of the Notes, waive any existing Default or Event of Default and its consequences under this Note except a continuing Default or Event of Default in the payment of the principal of, or premium on, the Notes. Upon
any such waiver, such Default shall cease to exist, and any Event of Default arising 

  
 13 

 
therefrom shall be deemed to have been cured for every purpose of this Note, but no such waiver shall extend to any subsequent or other default or impair any right consequent thereon. 

(e) Control by Majority. Holders of a majority in aggregate principal amount of the then outstanding Notes may
direct the time, method and place of conducting any proceeding for exercising any remedy available upon an Event of Default. 
 (f) Rights of Holders of Notes to Receive Payment. Notwithstanding any other provision of this Note, the right of the Holder of this Note to receive payment of the principal of, and premium on,
this Note, on or after the respective due dates expressed in the Note (including in connection with a redemption or an offer to purchase), or to bring suit for the enforcement of any such payment on or after such respective dates, shall not be
impaired or affected without the consent of such Holder 
 6. Limitation on Debt and Liens. The Company
will not, and will not permit its Subsidiaries to, directly or indirectly, create, incur, issue, assume, guarantee or otherwise become directly or indirectly liable, contingently or otherwise, with respect to any Debt, and the Company will not issue
any Disqualified Stock and the Company will not permit its Subsidiaries to issue shares of preferred stock except for: 
 (a) Debt in an amount outstanding at any time not to exceed the greater of (i) $200 million in aggregate principal amount or (ii) 50% of the Company’s total consolidated assets (as set
forth on its most recent balance sheet prepared in accordance with GAAP and filed with the Securities and Exchange Commission after giving effect to any reductions or additions to assets in accordance with GAAP since the date of such balance sheet)
(and provided that Debt incurred pursuant to this clause (a) that is secured by a Lien on assets of the Company shall not exceed the greater of (i) $125 million in aggregate principal amount or (ii) 30% of the Company’s total
consolidated assets (as set forth on its most recent balance sheet prepared in accordance with GAAP); 
 (b)
Debt in existence on the Closing Date; 
 (c) the incurrence by the Company or any of its Subsidiaries of Debt
represented by Capital Lease Obligations, mortgage financings or purchase money obligations, in each case, incurred for the purpose of financing all or any part of the purchase price or cost of design, construction, installation or improvement of
property, plant or equipment used in the business of the Company or any of its Subsidiaries. 
 (d) Debt of the
Company that is (i) contractually subordinated in right of payment to the Notes, (ii) matures 91 days after the Notes and (iii) is less than $50 million in aggregate principal amount at any one time outstanding; 

(e) Debt of the Company (A) in respect of performance, surety or appeal bonds or letters of credit in the ordinary
course of business, or (B) under interest rate, currency, commodity or similar hedges, swaps and other derivatives entered into with one or more financial institutions that is designed to protect such the Company against fluctuations in
interest rates or currency exchange rates, commodity prices or other market fluctuations and is not entered into for speculative purposes; and 

  
 14 

 (f) Debt which is exchanged for or the proceeds of which are used to
refinance or refund, or any extension or renewal of (each a “refinancing”), (1) the Notes or (2) debt in existence on the Closing Date, and (3) Debt incurred pursuant to clause (c) of this paragraph, in each case in an
aggregate principal amount not to exceed the principal amount of the Debt so refinanced (together with any accrued interest and any premium and other payment required to be made with respect to the Debt being refinanced or refunded, and any fees,
costs, expenses, underwriting discounts or commissions and other payments paid or payable with respect to the Debt incurred pursuant to this clause (f)); provided, however, that (A) Debt, the proceeds of which are used to refinance the
Notes, or Debt which is pari passu with or subordinate in right of payment to the Notes, shall only be permitted if (x) in the case of any refinancing of the Notes or Debt which is pari passu to the Notes, the refinancing Debt is Incurred by
the Company and made pari passu to the Notes or subordinated to the Notes, and (y) in the case of any refinancing of Debt which is subordinated to the Notes, the refinancing Debt is incurred by the Company and is subordinated to the Notes in a
manner that is at least as favorable to the Holders as that of the Debt refinanced; (B) refinancing Debt with respect to Debt incurred pursuant to clause (c) of this paragraph shall not be secured by a Lien on any assets other than the
assets securing the Debt so refinanced, and any improvements or additions thereto, and (C) the refinancing Debt by its terms, or by the terms of any agreement or instrument pursuant to which such Debt is issued, does not have a final maturity
prior to the final maturity of the Debt being refinanced. 
 For purposes of determining compliance with this
Section 6, in the event that an item of Debt meets the criteria of more than one of the types of Debt described in the above clauses the Company, in its sole discretion, shall classify, and from time to time may reclassify, such item of Debt.

 The Company will not create, incur, assume or suffer to exist any Lien of any kind on any asset now owned or
hereafter acquired, except for (a) the Liens described in Section 6(a) and 6(c) (including the refinancing of Liens described in Section 6(c) pursuant to Section 6(f)), (b) Permitted Liens, and (c) any Liens in
existence on the Closing Date (including the refinancing thereof pursuant to Section 6(f)). 
 As used
herein, “Permitted Liens” means the following: (a) Liens for taxes, assessments and governmental charges or levies that are not overdue for a period of more than thirty (30) days or which are being contested in good faith;
(b) Liens imposed by law, such as materialmen’s, mechanics’, carriers’, workmen’s and repairmen’s Liens and other similar Liens securing obligations that are not overdue for a period of more than thirty (30) days
or that are being contested in good faith; (c) pledges or deposits to secure obligations under workers’ compensation laws or similar legislation or to secure public or statutory obligations; (d) easements, rights of way and other
encumbrances on title to real property that do not render title to the property encumbered thereby unmarketable or materially adversely affect the use of such property for its present purposes; (e) Liens to secure the performance of bids, trade
contracts, leases, statutory obligations, surety and appeal bonds, performance bonds and other obligations of a like nature; (f) landlords’ Liens under leases; (g) Liens consisting of leases, subleases, licenses or sublicenses granted
to others and not interfering in any material respect with the business of the Company and its Subsidiaries, taken as a whole, and any interest or title of a lessor or licensor under any lease or license, as applicable; (h) Liens arising solely
by virtue 

  
 15 

 
of any statutory or common law provision relating to banker’s Liens, rights of set-off or similar rights and remedies as to deposit accounts or other funds maintained with a creditor
depository institution; and (i) Liens securing judgments for the payment of money not constituting an Event of Default under Section 5(a)(vi) or securing appeal or other surety bonds related to such judgments. 

7. Successors. 
 (a) Merger, Consolidation or Sale of Assets. The Company shall not consolidate or merge with or into (whether or not the Company is the surviving corporation), or sell, assign, transfer, lease,
convey or otherwise dispose of all or substantially all of its properties or assets in one or more related transactions, to another corporation, Person or entity unless: 

(i) the entity or Person formed by or surviving any such consolidation or merger (if other than the Company), or the
parent company thereof, or the entity or Person to which such sale, assignment, transfer, lease, conveyance or other disposition shall have been made assumes all the obligations of the Company under the Notes and the Agreement; and 

(ii) immediately after such transaction no Default or Event of Default exists. 

(b) Successor Corporation Substituted. Upon any consolidation or merger or any transfer of all or substantially
all of the assets of the Company in accordance with Section 7(a) hereof, the successor Person formed by such consolidation or into which the Company is merged, or the parent company thereof, or to which such transfer is made shall succeed to
and (except in the case of a lease) be substituted for (so that from and after the date of such consolidation, merger or transfer, the provisions of this Note, the Agreement and the Registration Rights Agreement referring to the “Company”
shall refer instead to the successor Person and not to the Company), and may exercise every right and power of, the Company under this Note and the Agreement with the same effect as if such successor Person had been named herein as the Company, and
(except in the case of a lease) the Company shall be released from the obligations under the Notes and the Agreement except with respect to any obligations that arise from, or are related to, such transaction. 

8. Amendment and Waiver. Except as otherwise expressly provided herein, the provisions of this Note may be amended
and the Company may take any action herein prohibited, or omit to perform any act herein required to be performed by it, only if the Company has obtained the written consent of the Holders of at least a majority of the aggregate principal amount
then outstanding of the Notes; provided that no such action shall change (i) the amount of Notes whose Holders must consent to an amendment, (ii) reduce the amount of or any provision relating to the scheduled payment of principal of the
Notes, (iii) change the time at which any Note must be repurchased or amend the conversion rights as set forth under Sections 3 or 4, (iv) make any Note payable in any money or at any place other than as stated in the Note, (v) impair the
right of any Holder to receive payments of principal of, or premium on, such Holder’s Notes on or after the due dates therefore or to institute suit for the enforcement of any payment on or with respect to such Holder’s Notes, or
(vi) make any change in the amendment provisions which require each Holder’s consent or in the waiver provisions, in each such case without the consent of the applicable Holder if such change is adverse to such Holder. 

  
 16 

 9. Place of Payment. Payments of principal, interest, and premium, if
any, consideration deliverable upon conversion of this Note (unless otherwise specified in the conversion notice) and all notices and other communications to the Investor hereunder or with respect hereto are to be delivered to the Investor at the
address identified in the Agreement or to such other address or to the attention of such other person as specified by prior written notice to the Company, including any transferee of this Note. 

10. Costs of Collection. In the event that the Company fails to (a) pay when due (including, without
limitation upon acceleration in connection with an Event of Default) the full amount of principal, interest and/or premium hereunder or (b) deliver when due the consideration deliverable upon conversion of this Note, the Company shall indemnify
and hold harmless the Holder of any portion of this Note from and against all reasonable costs and expenses incurred in connection with the enforcement of this provision or collection of such principal, interest, premium and/or consideration,
including, without limitation, reasonable attorneys’ fees and expenses. 
 11. Waivers. The Company
hereby waives presentment, demand, notice, protest and all other demands and notices in connection with the delivery, acceptance, performance, default or enforcement of this Note. 

12. Benefits of the Agreement. The Investor and all transferees of this Note (to the extent such transfer is
permitted by the Agreement) shall be entitled to the rights and benefits granted to them in the Agreement. 

13. Registration of Transfer and Exchange Generally. 

(a) Registration, Registration of Transfer and Exchange Generally. The Company shall keep at its principal
executive offices a register (the register maintained in such being herein sometimes collectively referred to as the “Note Register”) in which the Company shall provide for the registration of Notes and of transfers and
exchanges of Notes. 
 Subject to the provisions of the Agreement regarding restrictions on transfer and
provided the transferee agrees to be bound by the terms of the Agreement, upon surrender for registration of transfer of any Note at its principal executive office, the Company shall execute and deliver, in the name of the designated transferee or
transferees, one or more new Notes in denominations requested by the transferee (which denominations shall not be less than $1,000,000 per Note (unless the transferor holds a lesser denomination, in which case no such restriction shall apply)), of a
like aggregate principal amount and bearing such restrictive legends as may be required by law. 
 At the option
of a Holder, Notes may be exchanged for other Notes of any authorized denominations, of a like aggregate principal amount and bearing such restrictive legends as may be required by law upon surrender of the Notes to be exchanged at the
Company’s principal executive offices. Whenever any Notes are so surrendered for exchange, the Company shall execute and make available for delivery the Notes that the Holder making the exchange is entitled to receive. 

  
 17 

 All Notes issued upon any registration of transfer or exchange of Notes
shall be the valid obligations of the Company, evidencing the same debt, and entitled to the same benefits as the Notes surrendered upon such registration of transfer or exchange. 

Every Note presented or surrendered for registration of transfer or for exchange shall (if so required by the Company) be
duly endorsed, or be accompanied by a written instrument of transfer in form satisfactory to the Company, duly executed by the Holder thereof or his attorney duly authorized in writing. 

No service charge shall be made for any registration of transfer or exchange of Notes. 

(b) Mutilated, Destroyed, Lost and Stolen Notes. If any mutilated Note is surrendered to the Company, the Company
shall execute and make available for delivery in exchange therefor a new Note of like tenor and principal amount and bearing a number not contemporaneously outstanding. 

If there shall be delivered to the Company (i) evidence to its reasonable satisfaction of the destruction, loss or
theft of any Note and (ii) such indemnity as may be reasonably requested by the Company to save itself harmless, then, in the absence of notice to the Company that such Note has been acquired by a protected purchaser, the Company shall execute
and make available for delivery, in lieu of any such destroyed, lost or stolen Note, a new Note of like tenor and principal amount and bearing a number not contemporaneously outstanding. 

Every new Note issued pursuant to this Section 13 in lieu of any mutilated, destroyed, lost or stolen Note shall
constitute an original additional contractual obligation of the Company, whether or not the destroyed, lost or stolen Note shall be at any time enforceable by anyone. 

The provisions of this Section 13 are exclusive and shall preclude (to the extent lawful) all other rights and
remedies with respect to the replacement or payment of mutilated, destroyed, lost or stolen Notes. 
 14.
Governing Law. 
 (a) THIS NOTE, AND THE PROVISIONS, RIGHTS, OBLIGATIONS, AND CONDITIONS SET FORTH HEREIN,
AND THE LEGAL RELATIONS BETWEEN THE PARTIES HERETO, INCLUDING ALL DISPUTES AND CLAIMS, WHETHER ARISING IN CONTRACT, TORT, OR UNDER STATUTE, SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK WITHOUT GIVING EFFECT
TO ITS CONFLICT OF LAW PROVISIONS. 
 (b) Any and all disputes arising out of, or in connection with, the
interpretation, performance, or nonperformance of this Note or any and all disputes arising out of, or in connection with, transactions in any way related to this Note and/or the relationship between the parties shall be litigated solely and
exclusively before the United States District Court for the Southern District of New York. The parties consent to the in personam jurisdiction of said court for the purposes of any such litigation, and waive, fully and completely, any right to
dismiss and/or transfer any action pursuant to 28 U.S.C. § 1404 or 1406 (or any successor statute). In the event the United States District Court for the Southern District of New York does

  
 18 

 
not have subject matter jurisdiction of said matter, then such matter shall be litigated solely and exclusively before the appropriate state court of competent jurisdiction located in the state
of New York. 
 15. Notices. All notices, requests, and other communications hereunder shall be in
writing and will be deemed to have been duly given and received (a) when personally delivered, (b) when sent by facsimile upon confirmation of receipt, (c) one business day after the day on which the same has been delivered prepaid to
a nationally recognized courier service, or (d) five business days after the deposit in the United States mail, registered or certified, return receipt requested, postage prepaid, in each case addressed to Amyris, Inc., 5885 Hollis Street,
Suite 100, Emeryville, CA 94608, Attn: General Counsel, facsimile number: (510) 740-7416, with a copy to Fenwick & West LLP, 801 California Street, Mountain View, CA 94041, Attn: Dan Winnike, Esq., facsimile number:
(650) 938-5200, and as to the Investor at the address and facsimile number set forth in the Agreement. Any party hereto from time to time may change its address, facsimile number, or other information for the purpose of notices to that party by
giving notice specifying such change to the other parties hereto. Each Investor and the Company may each agree in writing to accept notices and other communications to it hereunder by electronic communications pursuant to procedures reasonably
approved by it; provided that approval of such procedures may be limited to particular notices or communications. 
 [Signature
Page Follows] 

  
 19 

 IN WITNESS WHEREOF, the Company has executed and delivered this Note on
February 27, 2012. 
  

			
	AMYRIS, INC.
		
	 By:
	 	  

	 Name:
	 	
	 Title:
	 	

 EXHIBIT 1 
 (To be Executed by Registered Holder in order to Convert Note) 

CONVERSION NOTICE 
 FOR 
 SENIOR UNSECURED CONVERTIBLE NOTE DUE 2017 

The undersigned, as Holder of the Senior Unsecured Convertible Note due 2017 of AMYRIS, INC., (the
“Company”), in the outstanding principal amount of U.S. $             (the “Note”), hereby elects to convert that portion of the
outstanding principal amount of the Note shown on the next page into shares of the Company’s common stock, $0.0001 par value per share (the “Common Stock”), of the Company, accrued and unpaid interest and Make-Whole
Interest, if any, in accordance with and in compliance with the conditions of the Note, as of the date written below. The undersigned hereby requests that share certificates for the shares of Common Stock to be issued to the undersigned pursuant to
this Conversion Notice be issued in the name of, and delivered to, the undersigned or its designee as indicated below. If shares are to be issued in the name of a person other than the undersigned, the undersigned will pay all transfer taxes payable
with respect thereto. No fee will be charged to the Holder for any conversion, except for transfer taxes, if any. 
  

							
	 Conversion Information:
	 		 	NAME OF HOLDER:
				
		 		 	 By:
	 	  

		 		 	 Print Name:

		 		 	 Print Title:

			
		 		 	 Print Address of Holder

			
		 		 	  

		 		 	
 

 

							
		 		 	 Issue Common Stock:
	 	  

 

							
		 		 	  at:
	 	  

							
			
		 		 	 Electronically transmit and credit Common

Stock to
                                   at:
                                        

		 		 	  

			
		 		 	 Date of Conversion

			
		 		 	  

			
		 		 	 Applicable Conversion Price

			
		 		 	  

 THE COMPUTATION OF THE NUMBER OF SHARES OF COMMON STOCK TO 

BE RECEIVED IS SET FORTH ON THE ATTACHED PAGE 

			
	 Page 2 to Conversion Notice for:
	 	  

		 	(Name of Holder)

 COMPUTATION OF NUMBER OF COMMON SHARES TO BE RECEIVED 

 

							
	 Face Amount converted:
	 		  	$	                  	  
			
	 Conversion Price
	 		  	$	 	  
			
	 Number of shares of Common

Stock =
	 	Total dollar amount converted =	  	$	 	  
		 	Conversion Price	  			
			
	 Number of shares of Common

Stock =
	 		  			

 If the conversion is not being settled by DTC, please
issue and deliver              certificate(s) for shares of Common Stock in the following amount(s): 
  

	
	  

	
	  

	
	  

	
	  

 Please issue and deliver
             new Note(s) in the following amounts:

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