Document:

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                        THIRD AMENDMENT TO LEASE BETWEEN

                      SCIENCE PARK DEVELOPMENT CORPORATION

                                       and

                        GENAISSANCE PHARMACEUTICALS, INC.

Date:    June 1, 2000

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         This Third Amendment to Lease (this "Third Amendment") is made and
entered into as of the first day of June, 2000 by and between SCIENCE PARK
DEVELOPMENT CORPORATION, a Connecticut corporation having a principal place of
business at 25 Science Park, Suite 223, New Haven, Connecticut 06511 (herein
referred to as "LANDLORD") and GENAISSANCE PHARMACEUTICALS, INC., a Delaware
corporation having a principal place of business at Five Science Park, New
Haven, Connecticut 06511 (herein referred to as "TENANT").

         WHEREAS, Landlord and Tenant are parties to a certain Lease dated as of
September 15, 1998 (the "ORIGINAL LEASE") as amended by First Amendment to Lease
(the "FIRST AMENDMENT") and Second Amendment to Lease (the "SECOND AMENDMENT"),
each dated December 1, 1999 (collectively, the Original Lease, the First
Amendment and the Second Amendment shall hereinafter be referred to as the
"LEASE");

         WHEREAS, pursuant to the Lease, Tenant leases from Landlord certain
space in the buildings known as Building 5 North and Building 5 South in Science
Park, New Haven, Connecticut;

         WHEREAS, Tenant has requested to lease from Landlord: (i) approximately
6,470 rentable square feet of space on the East wing of the first floor of
Building 5 North as shown on the floor plan attached hereto as EXHIBIT A-1; (ii)
approximately 9,112 rentable square feet of space on the East wing of the first
floor of Building 5 South as shown on the floor plan attached hereto as EXHIBIT
A-1 (the space referred to in clauses (i) and (ii) above is herein referred to
collectively as the "1ST FLOOR EAST WING SPACE"); (iii) approximately 4,083
rentable square feet of space on the West wing of the third floor of Building 5
North as shown on the floor plan attached hereto as EXHIBIT A-2 (herein referred
to as the "PENTHOUSE"); (iv) 185 rentable square on the third floor of Building
5 South as shown on the floor plan attached hereto as EXHIBIT A-3 (the "THIRD
FLOOR SPACE"); and (v) the walkway connector between the Building 5 North 1st
Floor East Wing Space and the Building 5 South 1st Floor East Wing Space, if it
is built by Tenant, as shown on the floor plan attached hereto as EXHIBIT A-1
(herein referred to as the "FIRST FLOOR WALKWAY") (collectively, the 1st Floor
East Wing Space, the Penthouse, the Third Floor Space and the First Floor
Walkway shall herein be referred to as the "ADDITIONAL SPACE"; the Additional
Space, excluding the First Floor Walkway, is herein referred to as the "EXISTING
ADDITIONAL SPACE"), upon and subject to the terms, covenants and conditions
contained in the Lease as modified by this Third Amendment; and

         WHEREAS, Landlord and Tenant desire to amend the Lease in certain
respects;

         NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which is acknowledged by each of the parties, Landlord and Tenant
hereby agree as follows (capitalized terms used herein which are not otherwise
defined herein shall have the meaning given to such terms in the Lease):

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1.       REPRESENTATION AS TO CONDITION OF EXISTING ADDITIONAL SPACE; DELIVERY
         OF POSSESSION OF EXISTING ADDITIONAL SPACE. Landlord represents that
         Landlord has (i) caused to be removed from the Existing Additional
         Space all asbestos, which removal was performed in compliance with all
         applicable Environmental Laws and Title 19a ("Public Health and
         Well-Being") of the Connecticut General Statutes, including but not
         limited to Sections 19c-332 through 332e, concerning asbestos, and any
         regulations promulgated thereunder, (ii) caused to be removed from the
         Existing Additional Space all lead-based paint, which removal has been
         performed in compliance with applicable laws, such that as a result of
         the removal, no occupants of Building 5 North or South were exposed to
         airborne lead at levels over the action level, as defined in 29 CFR
         Section 1910.1025, and (iii) otherwise prepared the Existing Additional
         Space for delivery of same to Tenant in a vacant, broom clean
         condition, free of all furnishings, equipment, litter and debris.
         Subject to the foregoing representation, upon the execution and
         delivery of this Third Amendment, Landlord shall deliver to Tenant and
         Tenant shall accept from Landlord possession of the Existing Additional
         Space in its present as-is condition.

2.       REMOVAL OF SHED. The parties acknowledge and agree that, Landlord, at
         its expense, has (i) obtained required demolition permits and
         demolished that certain "shed" structure located in the intended area
         of the First Floor Walkway (the "Shed") , (ii) caused to be removed
         from the Shed prior to its demolition all asbestos, which removal was,
         to the best knowledge of Landlord, performed in compliance with all
         applicable Environmental Laws and Title 19a ("Public Health and
         Well-Being") of the Connecticut General Statutes, including but not
         limited to Sections 19c-332 through 332e, concerning asbestos, and any
         regulations promulgated thereunder, (iii) caused to be removed from the
         Shed all lead-based paint, which removal was, to the best knowledge of
         Landlord, performed in compliance with applicable laws, such that as a
         result of the removal no occupants of Building 5 North or South have
         been exposed to airborne lead at levels over the action level, as
         defined in 29 CFR Section 1910.1025.

3.       THIRD FLOOR SPACE.

         A.       The text of Section 2 of the Second Amendment is hereby
                  deleted and substituted therefor is the following:

                  "The rentable area of the Third Floor Space on the third floor
                  of Building 5 South is deemed to be 185 rentable square feet.
                  Tenant shall have exclusive possession of the Third Floor
                  Space."

         B.       The fourth sentence of Section 7 of the Second Amendment is
                  hereby deleted.

         C.       The Third Floor Space (as defined herein) is contiguous to the
                  Third Floor Space (as defined in the Second Amendment),
                  however, for purposes of the Lease and this Amendment,
                  including without limitation, for purposes of calculating all
                  rentable obligations under the Second Amendment and under this
                  Third Amendment, they shall be treated as separate spaces
                  constituting 185 rentable square feet each.

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4.       DEFINITION OF INTERIOR WORK. Pursuant to the provisions of Sections
         2.4B, 2.4E - H and 2.6 of the Original Lease, Landlord at its expense
         shall undertake all of the Work described on EXHIBIT B-1 hereof (the
         "INTERIOR WORK"). Landlord hereby agrees to complete the Interior Work
         in a good and workmanlike fashion, otherwise Tenant relies on no
         warranties or representations, express or implied, of Landlord or any
         agent or other party associated with Landlord as to its condition or
         repair, or as to taxes or any other matter relating to the Additional
         Space, except as otherwise expressly provided in the Lease, as modified
         by this Third Amendment. In addition, Landlord's representation
         regarding compliance with laws set forth in the second sentence of
         Section 8.1 of the Original Lease is hereby deemed repeated with regard
         to the Interior Work, as is the limitation on Tenant's remedy set forth
         in the balance of said Section 8.1.

5.       INTERIOR WORK.

         A.       Landlord, at its expense, shall use its best efforts to
                  substantially complete the Interior Work so it does not delay
                  Tenant's completion of the Tenant's Work (as hereinafter
                  defined), but in any event, no later than four (4) months
                  following the Existing Additional Space Lease Commencement
                  Date (as hereinafter defined). In addition, Landlord
                  represents that all electrical, mechanical, plumbing and other
                  building systems serving the Additional Space will be in
                  working order on the Additional Space Rent Commencement Date
                  (as hereinafter defined).

         B.       Landlord and Tenant shall each use its best efforts to
                  collectively cause Fusco Corporation and Svigals Associates to
                  coordinate the Interior Work with the Tenant's Work (as
                  defined in Section 15 of this Third Amendment) with respect to
                  the Additional Space in order not to delay completion of the
                  Tenant's Work with respect to the Additional Space.

6.       EXISTING ADDITIONAL SPACE LEASE COMMENCEMENT DATE. Landlord hereby
         agrees to lease to Tenant and Tenant hereby agrees to lease from
         Landlord the Additional Space, upon and subject to the terms of the
         Lease, as modified by this Third Amendment. Landlord shall deliver, and
         Tenant shall accept, exclusive possession of the Existing Additional
         Space on the date of this Third Amendment first written above, which
         date shall be deemed to be the Lease Commencement Date with respect to
         the Existing Additional Space (the "EXISTING ADDITIONAL SPACE LEASE
         COMMENCEMENT DATE"). Landlord's delivery of exclusive possession shall
         be subject to entries by the Landlord and its contractors into the 1st
         Floor East Wing Space and the Third Floor Space only as necessary to
         complete the Interior Work prior to the date Tenant first occupies such
         portions of the Additional Space for its business purposes (the
         "OCCUPANCY DATE"). Because Tenant will not have exclusive possession of
         the 1st Floor East Wing Space or the Third Floor Space until the
         Occupancy Date, the parties hereby agree that the provisions of
         Sections 5.1, 7.2, 7.4, 7.5, 12,1E and 23.1 of the Original Lease shall
         not apply to Tenant with regard to the 1st Floor East Wing Space or the
         Third Floor Space until the Occupancy Date.

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7.       EXISTING ADDITIONAL SPACE. Commencing on the Existing Additional Space
         Lease Commencement Date, the Leased Premises shall be deemed to include
         the Existing Additional Space for all purposes under the Lease, and the
         terms, covenants and conditions of the Lease, as modified by this Third
         Amendment, shall govern the rights, obligations and liabilities of
         Landlord and Tenant with respect to the Existing Additional Space. The
         Leased Premises, as described in Section 1.1(a) of the Original Lease
         and as shown on Exhibits A-1 and A-2 of the Original Lease, are
         sometimes referred to in this Third Amendment as the "ORIGINAL LEASED
         PREMISES".

8.       CONFIRMATION OF TERMS. The Expiration Date of the initial 5-year Term
         of the Lease, as hereby amended, with respect to the entire Leased
         Premises, including without limitation, the Additional Space, is
         February 29, 2004. The date February 28, 2004 as it appears in the
         first sentence of Section 5 of the First Amendment and in the first
         sentence of Section 9 of the Second Amendment is hereby deleted and
         "February 29, 2004" is substituted therefor in each sentence. The two
         5-year Extension Options granted in Section 2.2 of the Original Lease
         shall apply to the entire Leased Premises, including without
         limitation, the Additional Space. The First Amendment Space Lease
         Commencement Date (as defined in the First Amendment) occurred on
         January 14, 2000, and the Additional Space Lease Commencement Date (as
         defined in the Second Amendment) occurred on February 7, 2000. Tenant
         may not exercise an Extension Option with respect to less than the
         entire Leased Premises.

9.       RENT COMMENCEMENT DATE.

         A.       1ST FLOOR EAST WING SPACE. Subject to extensions pursuant to
                  Sections 2.3B. and 2.3C. of the Original Lease, the Rent
                  Commencement Date with respect to the 1st Floor East Wing
                  Space and the Third Floor Space (the "1ST FLOOR EAST WING RENT
                  COMMENCEMENT DATE ") shall mean the earlier of: (i) the date
                  of the issuance of a temporary or permanent certificate of
                  occupancy for all or any portion of the 1st Floor East Wing
                  Space and the Third Floor Space, or (ii) four (4) months after
                  the date of this Third Amendment first written above.

         B.       PENTHOUSE. Subject to extensions pursuant to Sections 2.3B.
                  and 2.3C. of the Original Lease, the Rent Commencement Date
                  with respect to the Penthouse (the "PENTHOUSE RENT
                  COMMENCEMENT DATE") shall mean May 9, 2000.

         C.       INTERPRETATION. In interpreting the provisions of Sections
                  2.3B and 2.3C of the Lease to this Third Amendment, the term,
                  "Interior Work" as used therein shall mean "Interior Work" as
                  defined herein, and the term, "Rent Commencement Date" as used
                  therein shall mean (i) with respect to the 1st Floor East Wing
                  Space and the Third Floor Space, the "1st Floor East Wing Rent
                  Commencement Date", and (ii) with respect to the Penthouse,
                  the "Penthouse Rent Commencement Date", as defined herein. At
                  the request of either Landlord or Tenant, Landlord and Tenant
                  shall execute and deliver to each other a writing confirming
                  the First Floor Walkway Rent Commencement Date (as hereinafter
                  defined), the 1st Floor East Wing Rent Commencement Date, and
                  the Penthouse Rent Commencement Date.

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10.      RENT.

         A.       Because Tenant will bear the cost of building the First Floor
                  Walkway if it is built, Tenant shall pay Additional Rent, but
                  shall have no obligation to pay Base Rent, for the First Floor
                  Walkway during the Term or any Extension Term. Tenant's
                  obligation to pay Additional Rent with respect to the First
                  Floor Walkway shall commence on the date of the issuance of a
                  temporary or permanent certificate of occupancy for the First
                  Floor Walkway ("FIRST FLOOR WALKWAY RENT COMMENCEMENT DATE"),
                  and continue thereafter until the Expiration Date of the
                  Lease.

         B.       1ST FLOOR EAST WING SPACE BASE RENT - INITIAL TERM. In
                  accordance with the provisions of this Third Amendment, Tenant
                  shall pay to Landlord Base Rent with respect to the 1st Floor
                  East Wing Space and the Third Floor Space at the rate of Nine
                  Dollars and Fifty Cents ($9.50) per rentable square foot of
                  the 1st Floor East Wing Space per annum commencing on the 1st
                  Floor East Wing Rent Commencement Date, and continuing
                  thereafter until February 29, 2004. Landlord and Tenant hereby
                  stipulate to the rentable area of the 1st Floor East Wing
                  Space as set forth in the third Whereas clause to this Third
                  Amendment.

                  PENTHOUSE BASE RENT - INITIAL TERM. In accordance with the
                  provisions of this Third Amendment, Tenant shall pay to
                  Landlord Base Rent with respect to the Penthouse at the rate
                  of Fourteen and 56/100 Dollars ($14.56) per rentable square
                  foot of the Penthouse per annum commencing on the Penthouse
                  Rent Commencement Date, and continuing thereafter until
                  February 29, 2004. Landlord and Tenant hereby stipulate to the
                  rentable area of the Penthouse as set forth in the third
                  Whereas clause to this Third Amendment.

                  BASE RENT - EXTENSION TERMS. Notwithstanding Section 3.1C. of
                  the Original Lease or anything else to the contrary contained
                  in the Lease, during the first 5-year Extension Term,
                  commencing on March 1, 2004 and ending on February 28, 2009,
                  if any, and the second 5-year Extension Term (commencing on
                  March 1, 2009 and ending on February 28, 2014), if any,
                  respectively, with respect to the Existing Additional Space
                  only, Tenant shall pay to Landlord a Base Rent equal to ninety
                  percent (90%) of the then fair market value rent for the
                  Existing Additional Space as determined by mutual agreement
                  between the parties, or if the parties fail to agree, as shall
                  be determined by arbitration in accordance with the Rules of
                  Commercial Arbitration of the American Arbitration Association
                  then in effect. In the event arbitration is necessary,
                  Landlord and Tenant shall each select one arbitrator, each of
                  whom shall be a commercial real estate broker with at least
                  ten (10) years of experience in the New Haven commercial real
                  estate market. If the two arbitrators are unable to agree on
                  the fair market value rent within fifteen days of their
                  selection, they shall appoint a third arbitrator and the
                  determinations of fair market value rent by the third
                  arbitrator so selected shall be final. The decision of the
                  arbitrators shall be binding on the parties. Each party shall
                  pay the fees and expenses of the arbitrator it selects and
                  the fees and

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                  expenses of the third arbitrator, if one is necessary, shall
                  be shared equally by the parties.

         C.       ADDITIONAL RENT. Notwithstanding anything to the contrary
                  contained herein, for purposes of calculating each and every
                  instance where Additional Rent is payable hereunder with
                  regard to the Additional Space, the Additional Space shall be
                  deemed to include 100% of the rentable area of the Existing
                  Additional Space and the First Floor Walkway, if it is built,
                  as determined in accordance with the provisions of Section 16
                  hereof. With respect to: (i) the 1st Floor East Wing Space and
                  the Third Floor Space, commencing on the 1st Floor East Wing
                  Space Rent Commencement Date, (ii) the Penthouse, commencing
                  on the Penthouse Rent Commencement Date, and (iii) the First
                  Floor Walkway, commencing on the First Floor Walkway Rent
                  Commencement Date, and, in each case, continuing thereafter
                  until the Expiration Date of the Lease, Tenant shall: (i) pay
                  for electricity and gas consumed in the portion of the
                  Additional Space in question in accordance with Section 3.4 of
                  the Original Lease, (ii) pay Additional Rent with respect to
                  the portion of the Additional Space in question in accordance
                  with Section 3.5 of the Original Lease, as modified by this
                  Third Amendment.

         D.       OPERATING EXPENSE PAYMENTS. In addition to Base Rent and other
                  Additional Rent due and payable by Tenant pursuant to the
                  other provisions of this Lease, Tenant shall pay to Landlord,
                  as Additional Rent, commencing on the 1st Floor East Wing Rent
                  Commencement Date (with respect to the 1st Floor East Wing
                  Space and the Third Floor Space), and commencing on the First
                  Floor Walkway Rent Commencement Date (with respect to the
                  First Floor Walkway), an amount equal to Tenant's OE Share (as
                  herein defined) of Operating Expenses paid or incurred by
                  Landlord during the Term of this Lease or any Extension Term,
                  regardless of whether any Operating Expense Year occurs in
                  whole or in part during the Term or any Extension Term;
                  provided, however, that for purposes of calculations made
                  under this Paragraph 10.D., in no event shall Landlord charge
                  Tenant more than Tenant's OE Share of 100% of the actual cost
                  of Operating Expenses incurred by Landlord.

                  ESTIMATED OE PAYMENTS. Additional Rent due and payable by
                  Tenant to Landlord pursuant to this Paragraph 10. D. shall be
                  paid in the following manner:

                           (a)      Landlord shall reasonably estimate in
                  advance the amounts Tenant shall owe under this Article for
                  any full or partial Operating Expense Year. Beginning in the
                  first Operating Expense Year, Tenant shall pay such estimated
                  amounts, on a monthly basis, on or before the first day of
                  each calendar month during the first and each following
                  Operating Expense Year. Such estimate may be reasonably
                  adjusted from time to time by Landlord.

                           (b)      Within 120 days after the end of each
                  Operating Expense Year, or as soon thereafter as practicable,
                  Landlord shall provide a statement (the "STATEMENT") to Tenant
                  showing: (i) the amount of actual Operating Expenses

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                  for such Operating Expense Year, with a listing of amounts for
                  major categories of Operating Expenses, (ii) any amount paid
                  by Tenant towards Additional Rent payable under this Article
                  during such Operating Expense Year on an estimated basis,
                  (iii) any revised estimate of Tenant's obligations for
                  Operating Expenses for the current Operating Expense Year, and
                  (iv) a calculation of whether the Operating Expense Cap has
                  been exceeded.

                           (c)      If the Statement shows that the estimated
                  payments made by Tenant during the Operating Expense Year were
                  less than Tenant's actual obligations for the payment of
                  Additional Rent under this Paragraph 10. D. for such Year,
                  Tenant shall pay the difference. If the Statement shows an
                  increase in Tenant's estimated payments for the current
                  Operating Expense Year, Tenant shall pay the difference
                  between the new and former estimates, for the period from the
                  first day of the then-current Operating Expense Year through
                  the month in which the Statement is sent. Tenant shall make
                  such payments within thirty (30) days after the Statement is
                  deemed to have been given under the terms of this Lease.

                           (d)      If the Statement shows that Tenant's
                  estimated payments exceeded Tenant's actual obligations for
                  the payment of Operating Expenses under this Paragraph 10. D.,
                  then Tenant shall receive a credit for the difference against
                  payments of rent next due. If the Term shall have expired and
                  no further rent shall be due, Tenant shall receive a refund of
                  such difference, within sixty (60) days after Landlord sends
                  the Statement.

                           (e)      No delay by Landlord of nine (9) months or
                  less in providing the Statement (or separate statements) shall
                  be deemed a default by Landlord or a waiver of Landlord's
                  right to require payment of Tenant's obligations under this
                  Article. After such nine (9) month period, Landlord shall be
                  estopped from billing for past Operating Expenses.

                  BOOKKEEPING AND AUDITING. Landlord shall maintain records
                  respecting Operating Expenses and determine the same in
                  accordance with sound accounting and management practices,
                  consistently applied. Tenant or its representative shall have
                  the right to examine those books and records of Landlord and
                  any managing agent reasonably necessary for purposes of
                  auditing the Statement in question, provided Tenant gives
                  Landlord reasonable prior notice specifying the particular
                  respects in which the Statement is claimed to be incorrect.
                  Such examination shall take place during normal business hours
                  at the place or places where such records are normally kept
                  with forty-five (45) days following such notice from Tenant.
                  Each Statement shall be considered final, except as to matters
                  to which exception is taken after examination of Landlord's
                  records in the foregoing manner and within the foregoing
                  times. If Tenant takes exception to any matter contained in
                  the Statement as provided herein, Landlord shall refer the
                  matter to an independent certified public accounting firm
                  having a national practice, whose certification as to the
                  proper amount shall be final and conclusive as between

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                  Landlord and Tenant. Tenant shall promptly pay the cost of
                  such certification unless such certification determines that
                  Tenant was overbilled by more than two (2%) percent. Pending
                  resolution of any such exceptions in the foregoing manner,
                  Tenant shall continue paying, without prejudice to Tenant's
                  position, Tenant's OE Share of Operating Expenses paid or
                  incurred during the applicable Operating Expense Year in the
                  amounts determined by Landlord, subject to adjustment after
                  any such exceptions are resolved.

                  SURVIVAL. The parties' obligations set forth in this Paragraph
                  10. D shall survive the expiration or earlier termination of
                  this Lease for a period of one year, but such survival shall
                  not be deemed to effect the waiver set forth in subparagraph
                  10.D(e) hereof.

                  For purposes of this Paragraph 10.D., "Operating Expenses"
                  shall have the meaning given to such term in Paragraph 37.1
                  (e) of the Lease, as qualified by Paragraph 37.1 (f) of the
                  Lease. The Operating Expense Cap, as defined in Paragraph 37.1
                  (h) of the Lease, shall not apply to the 1st Floor East Wing
                  Space, the Third Floor Space or the First Floor Walkway (if it
                  is built), as defined herein.

                  For purposes of this Paragraph 10.D., "Building" shall have
                  the meaning given to such term in Paragraph 37.1 (c) of the
                  Lease.

                  For purposes of this Paragraph 10.D., "Operating Expense Year"
                  shall mean calendar year 2000 and each calendar year
                  thereafter any portion of which occurs during the Term of the
                  Lease. Notwithstanding the foregoing, the first Operating
                  Expense Year shall commence on the 1st Floor East Wing Rent
                  Commencement Date (with respect to the 1st Floor East Wing
                  Space and the Third Floor Space), and shall commence on the
                  First Floor Walkway Rent Commencement Date (with respect to
                  the First Floor Walkway) and shall end on December 31, 2000,
                  and the last Operating Expense Year shall end on the last day
                  of the Term or the last day of any Extension Term. Tenant's
                  obligation under this Paragraph 10.D. to pay estimated and
                  actual amounts towards Operating Expenses for the first and
                  last Operating Expense Year shall be prorated by multiplying
                  the total estimated or actual (as the case may be) Operating
                  Expenses paid or incurred during the first or last (as the
                  case may be) Operating Expense Year, by a fraction, the
                  numerator of which shall be the number of days in the first or
                  last (as the case may be) Operating Expense Year, and the
                  denominator of which shall be 365.

                  For purposes of this Paragraph 10.D., "Tenant's OE Share"
                  shall mean a fraction, the numerator of which shall be the
                  total number of rentable square feet in the First Floor East
                  Wing Space plus the Third Floor Space (185 rentable square
                  feet) and the denominator of which shall be the total number
                  of rentable square feet in the Building. If the First Floor
                  Walkway is built, the rentable square footage of the Building
                  and the 1st Floor East Wing Space shall be deemed for purposes
                  of calculating Tenant's OE Share to include the rentable
                  square footage of the First Floor Walkway, as the case may be.

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                  For purposes of this Paragraph 10.D., "Park Expenses" shall
                  have the meaning given to such term in Paragraph 37.1 (j) of
                  the Lease.

                  GROSS UP PROVISION. If the Building is not fully occupied
                  during all or a portion of any Operating Expense Year,
                  Landlord may, in accordance with sound accounting and
                  management practices, determine the amount of Operating
                  Expenses actually paid or incurred by Landlord that would have
                  been included in Operating Expenses had the Building been
                  fully occupied and the amount so determined shall be deemed to
                  have been the amount of Operating Expenses for such year,
                  subject to the first sentence of this Section 10D.

         E.       OPERATING EXPENSES FOR PENTHOUSE.
                  Tenant's obligation to pay Operating Expenses for the
                  Penthouse shall be governed by the provisions of Section 17 of
                  the Second Amendment except that:

                           (a)      With respect to the Penthouse, "BASE EXPENSE
                  YEAR" shall mean the twelve (12) month period commencing on
                  the Penthouse Rent Commencement Date.

                           (b)      With regard to the Penthouse, "TENANT'S OE
                  SHARE" shall mean a fraction, the numerator of which shall be
                  the total of the rentable area of the Penthouse and the
                  denominator of which shall be the total number of rentable
                  square feet in the Building 5 North and Building 5 South, plus
                  the rentable area of the Bridge and/or the First Floor
                  Walkway, if either is built.

                           (c)      Tenant's obligation to begin paying
                  Operating Expenses with respect to the Penthouse shall not
                  commence until the first Operating Expense Year occurring
                  immediately following the Base Expense Year attributable to
                  the Penthouse.

                           (d)      On or before the first day of each Operating
                  Expense Year following the Base Expense Year attributable to
                  the Penthouse, Landlord shall give Tenant statements of the
                  estimated amount of increase in Operating Expenses that Tenant
                  will owe with respect to such space for ensuing Operating
                  Expense Year, and Tenant shall make payments monthly in
                  accordance with such statement.

11.      DEFINITIONS. The first sentence of Section 4.1(d) of the Original
         Lease, Section 8(b) of the First Amendment and Paragraph 12 of the
         Second Amendment are hereby deleted and substituted therefor is the
         following:

                  "Tenant's Pro-Rata Share" shall mean a fraction, the numerator
                  of which shall be the total number of rentable square feet in
                  the Leased Premises (taking into account that the rentable
                  area of the Additional Space, as defined in the Second

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                  Amendment, shall be calculated in accordance with the
                  provisions of Section 11(b) of the Second Amendment and the
                  Additional Space, as defined in the Third Amendment, shall be
                  calculated in accordance with the provisions of Paragraph 16
                  of the Third Amendment), as the same may increase or decrease
                  from time to time, and the denominator of which shall be the
                  total number of rentable square feet in Building 5 North and
                  Building 5 South combined, as same may increase or decrease
                  from time to time, plus (i) the rentable area of the First
                  Floor Walkway, if it is built, and (ii) the rentable area of
                  the Bridge (as such term is defined in the Second Amendment),
                  if it is built; Landlord represents that as of the date hereof
                  the combined area of Building 5 North and Building 5 South,
                  excluding the Bridge and the First Floor Walkway, measured in
                  rentable square feet is approximately 102,938 rentable square
                  feet.

12.      TAX PAYMENT.

         A.       Commencing on the 1st Floor East Wing Rent Commencement Date,
                  Paragraph 13 of the Second Amendment is hereby deleted and
                  substituted therefor is the following:

                  "Commencing on the 1st Floor East Wing Rent Commencement Date
                  (as defined in the Third Amendment), Tenant shall pay to
                  Landlord as Additional Rent due hereunder, for any Tax Year,
                  any part of which occurs after the 1st Floor East Wing Rent
                  Commencement Date and during the Term or any Extension Term,
                  an amount (the "TAX PAYMENT") equal to: (i) Tenant's Pro-Rata
                  Share (as defined in the Third Amendment) of the Taxes
                  attributable to the Base Building, plus (ii) 100% of the Taxes
                  attributable to Tenant's Work (which for purposes of the
                  balance of this Article 4 shall mean collectively Tenant's
                  Work as defined under the Original Lease, the First Amendment,
                  the Second Amendment and the Third Amendment)."

         B.       It is the parties' intent that the provisions of Sections
                  9(a)(iii), 9(b) and 9(c) of the First Amendment apply
                  generally to the Second Amendment and this Third Amendment and
                  govern specifically the parties' rights and obligations with
                  respect to Tax Payments, Enterprise Zone benefits and
                  apportionment of both hereunder.

13.      PARKING. The rental of the Additional Space will include the use of
         forty-seven (47) parking spaces in addition to the eighty (80) parking
         spaces provided for under the Original Lease, the twenty-five (25)
         parking spaces provided for under the First Amendment and the fifty
         (50) parking spaces provided for under the Second Amendment. The term
         "TENANT'S PARKING SPACES" shall be amended to include such additional
         forty-seven (47) parking spaces, bringing the total of Tenant's Parking
         Spaces to two hundred and two (202). Ten (10) of said additional
         forty-seven (47) parking spaces shall be made available to Tenant
         upon the execution and delivery of this Third Amendment, twenty (20) of
         said additional forty-seven (47) parking spaces shall be made available
         to Tenant

                                      10
<PAGE>

         as of the date Tenant takes occupancy of the 1st Floor East Wing
         Space for the purpose of conducting its business therein, and the
         remaining seventeen (17) parking spaces shall be made available to
         Tenant as of the date which is six (6) months after the date of this
         Third Amendment first written above. All of Tenant's Parking Spaces
         shall be located within the areas shown on EXHIBIT A-4 at all times
         during the Term or any Extension Term.

14.      AS-IS CONDITION. Subject to completion of the Landlord's obligations
         set forth in this Third Amendment, including without limitation,
         removal of the Shed and completion of the Interior Work, Landlord shall
         tender Tenant possession of the Additional Space in its then "as is"
         condition and Tenant agrees to accept possession of the Additional
         Space in its then "as is" condition, broom clean.

15.      TENANT'S WORK. Tenant, at Tenant's expense, agrees to make improvements
         to the Additional Space pursuant to plans and specifications approved
         by Landlord. Such improvements shall be deemed "TENANT'S WORK" and such
         plans and specifications shall be deemed "TENANT'S PLANS", and the
         terms of Section 2.7(a) of the Original Lease shall govern the approval
         of same. It is currently Tenant's intention that the Tenant's Work will
         include the construction of the First Floor Walkway. Tenant shall not
         be penalized in any manner if Tenant does not build the First Floor
         Walkway as part of the Tenant's Work. Tenant shall proceed with
         reasonable due diligence to perform Tenant's Work following funding of
         Tenant's new loan from Connecticut Innovations, Inc. (the "NEW CII
         LOAN") and the issuance of a building permit therefor.

16.      THE FIRST FLOOR WALKWAY. If Tenant builds the First Floor Walkway, then
         for all purposes under the Lease, the First Floor Walkway shall be
         deemed a part of the Leased Premises, except that Tenant shall not be
         required to pay Base Rent with respect to the First Floor Walkway. The
         rentable area of the First Floor Walkway shall be remeasured by Svigals
         Associates at Tenant's expense promptly after construction and included
         as part of the Leased Premises for purposes of calculating Tenant's
         Pro-Rata Share and for purposes of calculating Tenant's OE Share (as
         both terms are defined in this Third Amendment). The parties agree that
         the usable area and the rentable area of the First Floor Walkway will
         be the same. Similarly, if the First Floor Walkway is not constructed,
         the rentable area of the Leased Premises for purposes of calculating
         Additional Rent shall not include the rentable area of the First Floor
         Walkway. Tenant shall have no obligation to remove or restore the First
         Floor Walkway upon surrender of the Leased Premises to Landlord,
         notwithstanding the provisions of Section 6.2 of the Original Lease.

17.      LOBBY AND BATHROOMS. For all purposes under the Lease, the lobby and
         bathrooms between the Building 5 North 1st Floor East Wing Space and
         the Building 5 South 1st Floor East Wing Space shall not be deemed a
         part of the Additional Space and have not been and shall not be
         included in the calculation of Base Rent Tenant is obligated to pay
         hereunder. In addition, the rentable square footage of the said lobby
         and bathrooms shall not be included in the calculation of Tenant's
         Pro-Rata Share of Taxes under Article 4 of the Lease, as amended by
         this Third Amendment, and for purposes of calculating Tenant's OE Share
         as defined in Section 12 hereof.

                                      11
<PAGE>

18.      SUBORDINATION AND NON-DISTURBANCE. As used herein, the term "LANDLORD'S
         LENDER" shall mean and refer to the Connecticut Housing Finance
         Authority ("CHFA"), the Connecticut Development Authority ("CDA") and
         each future lender who may from time to time extend credit to Landlord
         which extensions of credit may be secured in whole or in part by a
         mortgage, deed of trust, ground lease or other security interest
         affecting the real property of which the Additional Space is a part.
         Tenant's obligations under this Third Amendment are subject to receipt
         of non-disturbance agreements from CDA and CHFA, both of which shall be
         substantially similar in form and content to the form of
         Non-Disturbance, Subordination and Attornment received from CDA and
         CHFA in connection with the execution of the First Amendment and the
         Second Amendment. Provided CHFA and CDA execute and deliver said
         non-disturbance agreements, the Lease, as modified by this Third
         Amendment, shall be subject and subordinated to: (a) all security
         interests in favor of CHFA and CDA affecting the Leased Premises,
         including without limitation the Additional Space, or the property of
         which the Leased Premises are a part, and (b) all present and future
         mortgages, deeds of trust and other security interests, including
         leasehold mortgages, granted by Landlord in favor of CHFA and CDA and
         affecting the Leased Premises, including without limitation the
         Additional Space, or the property of which the Leased Premises are a
         part. Tenant agrees to execute, at no expense to Landlord, any
         instrument which may reasonably be deemed necessary or desirable by
         Landlord, CHFA or CDA or to further effect the subordination of the
         Lease, as modified by this Third Amendment to Lease, to any such
         security interest, provided however, Tenant's non-disturbance rights
         are not affected. The Tenant's failure to strictly comply with this
         section will constitute an Event of Default under this Lease.

19.      NEW CII LOAN.

         A.       Section 15.1B of the Original Lease is hereby modified to
                  permit Tenant to assign its right, title and interest in and
                  to this Third Amendment without Landlord's consent to CII as
                  collateral security for the New CII Loan, or to any Tenant's
                  Lender as collateral security for a similar loan to Tenant.
                  Tenant's Lender, including, without limitation, CII shall be
                  entitled to assign its rights under this Third Amendment or to
                  sublet the Additional Space to any entity, subject to the
                  provisions set forth in subsections 15.1B(a)-(d) of the
                  Original Lease.

         B.       Upon at least five (5) business days notice, Landlord, at its
                  expense, hereby agrees to enter into a new Consent and
                  Intercreditor Agreement in form and content acceptable to CDA,
                  CII, CHFA and Landlord but relating to the New CII Loan and
                  this Third Amendment. Landlord hereby agrees to work with the
                  CDA, CII and CHFA to facilitate full execution of the new
                  Consent and Intercreditor Agreement by Landlord's Lenders. In
                  addition, Landlord hereby agrees that it will not raise
                  objection to any provisions in the new Consent and
                  Intercreditor Agreement that are substantially similar to the
                  original or amended Consent and Intercreditor Agreements
                  signed in connection with the Original Lease and the First and
                  Second Amendments, respectively.

                                       12
<PAGE>

         C.       Upon the closing of the New CII Loan, Landlord agrees to
                  execute and deliver an affidavit (a) verifying the
                  nonexistence of any tenants' rights in the Additional Space,
                  (b) verifying the nonexistence of any security interests in
                  personal property and fixtures that form a part of the
                  Additional Space, other than the rights therein, if any, of
                  the CDA and CHFA as the current Landlord's Lenders, and United
                  States Department of Commerce, Economic Development
                  Administration and (c) that Landlord has no notice of any
                  facts or circumstances not of record which could give rise to
                  the claim of any third party to rights of adverse possession
                  or use over the Additional Space or any part thereof in
                  derogation of Landlord's title. Upon the execution of this
                  Third Amendment, Landlord further agrees to obtain and deliver
                  a subordination of mechanic's liens, subordinated as to the
                  lien in favor of CII, executed by any contractor(s) who have
                  furnished any labor, services or materials in connection with
                  construction or repair work to the Building on behalf of
                  Landlord and would have a right to file a mechanic's lien that
                  would have priority over the mortgage filed in connection with
                  the New CII Loan.

20.      AMENDED NOTICE OF LEASE. Article 30 of the Original Lease is hereby
         amended to provide that at the request of either party, the notice of
         lease relating to the Original Lease shall be amended to reflect the
         addition of the Additional Space.

21.      EFFECT. The Lease, as modified by this Third Amendment, remains in full
         force and effect.

22.      MERGER. All understandings, letters of intent or agreements between
         Tenant and Landlord, which predate this Third Amendment are merged
         herein. No oral statements or representations or prior written
         communications by or between the parties dealing with the subject
         matter of this Third Amendment shall be binding or effective. This
         Third Amendment and the Lease are the sole and complete expression of
         the agreement between Landlord and Tenant as to the subject matter
         thereof.

23.      SEVERABILITY. If any of the provisions of this Third Amendment, or its
         application, is held by any court or in arbitration to be invalid or
         inapplicable, such decision shall not affect any other term, provision,
         covenant or condition of this Third Amendment. Notwithstanding the
         foregoing, if the invalid provision has the effect of reducing the rent
         to be paid by Tenant, Landlord may cancel the Lease.

24.      GOVERNING LAW. The laws of the State of Connecticut will govern the
         interpretation of this Third Amendment.

25.      BINDING NATURE AND TIME IS OF THE ESSENCE. This Third Amendment shall
         be binding upon the parties hereto and upon their heirs,
         administrators, executors, successors and assigns, and shall not be
         construed against the party that drafted it. The paragraph headings are
         for the parties' convenience and shall not be deemed to effect the
         meaning of this Third Amendment or otherwise. Time is of the essence
         with respect to all dates and

                                       13
<PAGE>

         time periods set forth in this Third Amendment.

                                       14
<PAGE>

         IN WITNESS WHEREOF, the parties hereto have hereunto set their hands
and seals as of the day and year first above written.

SCIENCE PARK DEVELOPMENT CORPORATION

By:      /s/ Dennis C. Lyndon
         ------------------------------
         Dennis C. Lyndon
         Director of Development
         Duly Authorized

GENAISSANCE PHARMACEUTICALS, INC.

By:      /s/ Kevin Rakin
         ------------------------------
         Kevin Rakin
         Executive Vice President
         Duly Authorized

                                       15
<PAGE>

         Pursuant to Section 34.2 of the Lease dated September 15, 1998 by and
between Science Park Development Corporation and Genaissance Pharmaceuticals,
Inc., the undersigned hereby consent to the foregoing Third Amendment to Lease.

CONNECTICUT DEVELOPMENT AUTHORITY

By:      Douglas G. Twele                   Date:    7/26/00
        -----------------------------              ------------------------
         Print Name:
         Print Title:

THE CONNECTICUT HOUSING FINANCE AUTHORITY

By:  /s/ John K. Claford                    Date:    7/24/00
        -----------------------------              ------------------------
         Print Name:
         Print Title:

CONNECTICUT INNOVATIONS, INC.

By:  /s/ Victor R. Budnick                  Date:    7/25/00
        -----------------------------              ------------------------
         Print Name:
         Print Title:

                                       16
<PAGE>

                                   EXHIBIT A-1

                     FLOOR PLAN OF 1ST FLOOR EAST WING SPACE
                        AND PROPOSED FIRST FLOOR WALKWAY

                                       1
<PAGE>

                                   EXHIBIT A-2

                             FLOOR PLAN OF PENTHOUSE

                                       1
<PAGE>

                                   EXHIBIT A-3

                                THIRD FLOOR SPACE

                                       1
<PAGE>

                                   EXHIBIT A-4

                            DESIGNATED PARKING AREAS

                                       2
<PAGE>

                                   EXHIBIT B-1

                                  INTERIOR WORK

1.       Piping and supply of chilled and hot water sufficient to operate
         Tenant's HVAC system will be installed up to the Additional Space.

2.       Modifications and/or upgrades to fire alarm system and sprinkler system
         if required by fire marshal.

3.       Installation of hot water supply and return.

4.       Installation of baseboard heating system.

5.       Window replacement work.

                                       3<PAGE>
                                                                   Exhibit 10.36

                                                               Customer No. 1083

                           LOAN AND SECURITY AGREEMENT

     THIS LOAN AND SECURITY AGREEMENT dated as of April 30, 1999, is made by
Genaissance Pharmaceuticals, Inc. (the "Borrower"), a Delaware corporation
having its principal place of business and chief executive office at Five
Science Park, New Haven, Connecticut, 06511, in favor of Transamerica Business
Credit Corporation, a Delaware corporation (the "Lender"), having its principal
office at 9399 West Higgins Road, Suite 600, Rosemont, Illinois 60018 and having
an office at 76 Batterson Park Road, Farmington, Connecticut 06032.

     WHEREAS, the Borrower has requested that the Lender make a Loan to the
Borrower; and

     WHEREAS, the Lender has agreed to make such Loan on the terms and
conditions of this Agreement.

     NOW, THEREFORE, in consideration of the premises and to induce the Lender
to extend credit, the Borrower hereby agrees with the Lender as follows:

     SECTION 1. DEFINITIONS.

     As used herein, the following terms shall have the following meanings, and
shall be equally applicable to both the singular and plural forms of the terms
defined:

     AGREEMENT shall mean this Loan and Security Agreement together with all
schedules and exhibits hereto, as amended, supplemented, or otherwise modified
from time to time.

     APPLICABLE LAW shall mean the laws of the State of Illinois (or any other
jurisdiction whose laws are mandatorily applicable notwithstanding the parties'
choice of Illinois law) or the laws of the United States of America, whichever
laws allow the greater interest, as such laws now exist or may be changed or
amended or come into effect in the future.

     BUSINESS DAY shall mean any day other than a Saturday, Sunday, or public
holiday or the equivalent for banks in New York City.

     CASH EQUIVALENTS means (1) securities issued, guaranteed or insured by the
United States or any of its agencies with maturities of not more than one year
from the date acquired; (ii) certificates of deposit with maturities of not more
than one year from the date acquired, issued by any U.S. federal or state
chartered commercial bank of recognized standing which has capital and
unimpaired surplus in excess of $100,000,000; (iii) investments in money market
funds registered under the Investment Company Act of 1940; (iv) mutual funds, at
least 90% of the assets of which constitute Cash Equivalents of the kinds
described in clauses (i) -- (iii) of this definition; and (v) other instruments,
commercial paper or investments acceptable to the Lender in its sole discretion.

     CLOSING DATE means the date first set forth above.

<PAGE>

     CODE shall have the meaning specified in Section 8(d).

     COLLATERAL shall have the meaning specified in Section 2.

     COLLATERAL ACCESS AGREEMENT shall mean any landlord waiver, mortgagee
waiver, bailee letter, or similar acknowledgment of any warehouseman or
processor in possession of any Collateral.

     CONTINGENT OBLIGATION means any direct, indirect, contingent or
non-contingent guaranty or obligation for the indebtedness of another Person,
except endorsements in the ordinary course of business.

     EFFECTIVE DATE shall mean the date on which all of the conditions specified
in Section 3.3 shall have been satisfied.

     EVENT OF DEFAULT shall mean any event specified in Section 7.

     FINANCIAL STATEMENTS shall have the meaning specified in Section 6.1.

     GAAP shall mean generally accepted accounting principles in the United
States of America, as in effect from time to time.

     LOANS shall mean the loans and financial accommodations made by the Lender
to the Borrower in accordance with the terms of this Agreement and any Note
delivered hereunder.

     LOAN DOCUMENTS shall mean, collectively, this Agreement, the Notes, and all
other present and future documents, agreements, certificates, and instruments
delivered by the Borrower under, in connection with or relating to this
Agreement, or any other present or future instrument or agreement between Lender
and Borrower, as each of the same may be amended, modified, extended, restated
or supplemented from time to time.

     MATERIAL ADVERSE CHANGE shall mean, with respect to any Person, a material
adverse change in the business, operations, results of operations, assets,
liabilities, or financial condition of such Person taken as a whole.

     MATERIAL ADVERSE EFFECT shall mean, with respect to any Person, a material
adverse effect on the business, operations, results of operations, assets,
liabilities, or financial condition of such Person taken as a whole.

     NOTE shall mean each Promissory Note, in substantially the form attached
hereto, made by the Borrower in favor of the Lender, as amended, supplemented,
or otherwise modified from time to time.

     OBLIGATIONS shall mean and include all loans (including the Loans),
advances, debts, liabilities, obligations, covenants and duties owing by
Borrower to Lender of any kind or nature, present or future, whether or not
evidenced by the Note or any note, guaranty or other instrument, whether or not
arising under or in connection with, this Agreement, any other Loan Document or
any other present or future instrument or agreement, whether or not for the

                                       2
<PAGE>

payment of money, whether arising by reason of an extension of credit, opening,
guaranteeing or confirming of a letter of credit, loan, guaranty,
indemnification or in any other manner, whether direct or indirect (including
those acquired by assignment, purchase, discount or otherwise), whether absolute
or contingent, due or to become due, now due or hereafter arising and however
acquired (including without limitation all loans previously made by Lender to
Borrower). The term includes, without limitation, all interest (including
interest accruing on or after an bankruptcy, whether or not an allowed claim),
charges, prepayment fees and charges due hereunder or in connection with any
Note, expenses, commitment, facility, closing and collateral management fees,
letter of credit fees, reasonable attorneys fees, taxes and any other sum
properly chargeable to Borrower under this Agreement, the other Loan Documents
or any other present or future agreement between Lender and Borrower.

     PERMITTED LIENS shall mean such of the following as to which no
enforcement, collection, execution, levy, or foreclosure proceeding shall have
been commenced: (a) liens for taxes, assessments, and other governmental charges
or levies or the claims or demands of landlords, carriers, warehousemen,
mechanics, laborers, materialmen, and other like Persons arising by operation of
law in the ordinary course of business for sums which are not yet due and
payable, or liens which are being contested in good faith by appropriate
proceedings diligently conducted and with respect to which adequate reserves are
maintained to the extent required by GAAP; (b) deposits or pledges to secure the
payment of worker's compensation, unemployment insurance, or other social
security benefits or obligations, public or statutory obligations, surety or
appeal bonds, bid or performance bonds, or other obligations of a like nature
incurred in the ordinary course of business; (c) licenses, restrictions, or
covenants for or on the use of the Collateral which do not materially impair
either the use of the Collateral in the operation of the business of the
Borrower or the value of the Collateral; (d) attachment or judgment liens that
do not constitute an Event of Default; (e) a lien on any item of equipment
created substantially simultaneously with the acquisition of such equipment for
the purpose of financing such acquisition, provided that such lien shall attach
only to the equipment acquired; (f) liens to Technology Investment Fund and the
Connecticut Department of Economic and Community Development ("CDECD") securing
obligations in the approximate amount of $438,000; (g) liens to CDECD securing
obligations in the approximate amount of $350,000: (h) leasehold mortgage to
Connecticut Innovation Incorporation in the approximate amount of $950,000 (i)
assignments or liens on leaseholds in connection with tenant improvements; and
(j) liens identified on SCHEDULE A.

     PERSON shall mean any individual, sole proprietorship, partnership,
limited liability partnership, joint venture, trust, unincorporated
organization, association, corporation, limited liability company,
institution, entity, party, or government (including any division, agency,
or department thereof), and the successors, heirs, and assigns of each.

     RECEIVABLE shall have the meaning set forth in Section 8(e).

     SCHEDULE shall mean Schedule A hereto containing certain information
pertaining to the Borrower.

     SOLVENT means, with respect to any Person, that as of the date as to which
such Person's solvency is measured:

                                       3
<PAGE>

          (a) the fair saleable value of its assets is in excess of the total
     amount of its liabilities (including contingent liabilities as valued in
     accordance with GAAP) as they become absolute and matured;

          (b) it has sufficient capital to conduct its business; and

          (c) it is able generally to meet its debts as they mature.

     TAXES shall have the meaning specified in Section 5.5.

     SECTION 2. CREATION OF SECURITY INTEREST: COLLATERAL. The Borrower hereby
assigns and grants to the Lender a continuing general, lien on, and security
interest in, all the Borrower's right, title, and interest in and to the
collateral described in the next sentence (the "Collateral") to secure the
payment and performance of all the Obligations, subject only to Permitted Liens.
Collateral means Receivables, Investment Property, Inventory, Equipment, and
Other Property and all additions and accessions thereto and substitutions and
replacements therefor and improvements thereon, and all proceeds (whether cash
or other property) and products thereof, including, without limitation, all
proceeds of insurance covering the same and all tort claims in connection
therewith, and all records, files, computer programs and files, data and
writings relating to the foregoing, and all equipment containing the foregoing.

     EQUIPMENT means all machinery, equipment, furniture, fixtures, conveyors,
tools, materials, storage and handling equipment, hydraulic presses, cutting
equipment, computer equipment and hardware, including central processing units,
terminals, drives, memory units, printers, keyboards, screens, peripherals and
input or output devices, molds, dies, stamps, vehicles, and other equipment of
every kind and nature and wherever situated now or hereafter owned by Borrower
or in which Borrower may have any interest as lessee or otherwise (to the extent
of such interest), together with all additions and accessions thereto, all
replacements and all accessories and parts therefor, all manuals, blueprints,
know-how, warranties and records in connection therewith, all rights against
suppliers, warrantors, manufacturers, sellers or others in connection therewith,
and together with all substitutes for any of the foregoing; and

     INVENTORY means all present and future goods intended for sale, lease or
other disposition by Borrower including, without limitation, all raw materials,
work in process, finished goods and other retail inventory, goods in the
possession of outside processors or other third parties, goods consigned to
Borrower to the extent of its interest therein as consignee, materials and
supplies of any kind, nature or description which are or might be used in
connection with the manufacture, packing, shipping, advertising, selling or
finishing of any such goods, and all documents of title or documents
representing the same; and

     INVESTMENT PROPERTY means any and all investment property of Borrower,
including all securities, whether certificated or uncertificated, security
entitlements, securities accounts, commodity contracts and commodity accounts,
and all financial assets held in any securities account or otherwise, wherever
located, and whether now existing or hereafter acquired or arising; and

     OTHER PROPERTY means all present and future instruments, documents,
documents of title, securities, bonds, notes, promissory notes, drafts,
acceptances, letters of credit and rights to

                                       4
<PAGE>

receive proceeds of letters of credit, deposit accounts, chattel paper,
certificates, insurance policies, insurance proceeds, leases, computer tapes,
causes of action, judgments, claims against third parties, leasehold rights in
any personal property, books, ledgers, files and records, general intangibles
(including without limitation, all contract rights, tax refunds, rights to
receive tax refunds, patents, patent applications, copyrights (registered and
unregistered), royalties, licenses, permits, franchise rights, authorizations,
customer lists, rights of indemnification, contribution and subrogation,
computer programs, discs and software, trade secrets, computer service
contracts, trademarks, trade names, service marks and names, logos, goodwill,
deposits, choses in action, designs, blueprints, plans, know-how, telephone
numbers and rights thereto, credits, reserves, and all forms of obligations
whatsoever now or hereafter owing to Borrower), all property at any time in the
possession or under the control of Lender, and all security given by Borrower to
Lender pursuant to any other loan document or agreement; and

     RECEIVABLES means all present and future accounts and accounts receivable,
together with all security therefor and guaranties thereof and all rights and
remedies relating thereto, including any right of stoppage in transit.

     SECTION 3. THE CREDIT FACILITY.

          SECTION 3.1. BORROWINGS. The Lender, subject to the terms and
     conditions of this Agreement, agrees to make a Loan to Borrower in a single
     drawdown, at Borrower's request, in a principal amount not to exceed
     $2,000,000. Such Loan shall be in an amount not less than $2,000,000.
     Notwithstanding anything herein to the contrary, the Lender shall be
     obligated to make such Loan only after the Lender, in its sole discretion,
     determines that the applicable conditions for borrowing contained in
     Sections 3.3 and 3.4 are satisfied. The timing and financial scope of
     Lender's obligation to make Loans hereunder are limited as set forth in a
     commitment letter executed by Lender and Borrower, dated as of April 9,
     1999 and attached hereto as EXHIBIT A (the "Commitment Letter").

          SECTION 3.2. APPLICATION OF PROCEEDS. The Borrower shall use the
     proceeds of the Loans for its general working capital purposes.

          SECTION 3.3. CONDITIONS TO LOAN.

          (a) The obligation of the Lender to make the Loan is subject to the
     Lender's receipt of the following, on or before the Closing Date, each
     dated the date of the Loan or as of an earlier date acceptable to the
     Lender, in form and substance satisfactory to the Lender and its counsel:

               (i) completed requests for information (Form UCC-11) listing all
          effective Uniform Commercial Code financing statements naming the
          Borrower as debtor and all tax lien, judgment, and litigation searches
          for the Borrower as the Lender shall deem necessary or desirable;

               (ii) acknowledgment copies of Uniform Commercial Code financing
          statements (naming the Lender as secured party and the Borrower as
          debtor), duly filed in all jurisdictions that the Lender deems
          necessary or desirable to perfect and protect the security interests
          created hereunder, and evidence that all other filings, registrations
          and recordings have

                                       5
<PAGE>

          been made in the appropriate governmental offices, and all other
          action has been taken, which shall be necessary to create, in favor
          of the Lender, a perfected first priority lien on the Collateral,
          subject only to Permitted Liens;

               (iii) a Note duly executed by the Borrower evidencing the amount
          of such Loan;

               (iv) an Intellectual Property Security Agreement, in form and
          substance satisfactory to the Lender and its counsel, duly executed by
          the Borrower, specifically identifying and granting to the Lender a
          security interest in all of the Borrower's intellectual property;

               (v) if requested by the Lender, a Collateral Access Agreement
          duly executed by the lessor or mortgagee, as the case may be, of each
          premises where the equipment Collateral is located;

               (vi) a Notice of Security Interest, in form and substance
          satisfactory to the Lender and its counsel, to each financial
          institution at which any deposit accounts of Borrower are maintained;

               (vii) the warrants described in the Commitment Letter, if any;

               (viii) certificates of insurance required under Section 5.4 of
          this Agreement together with loss payee endorsements for all such
          policies naming the Lender as lender loss payee and as an additional
          insured;

               (ix) a certificate of the Secretary or an Assistant Secretary of
          the Borrower ("Secretary's Certificate") certifying (A) that attached
          to the Secretary's Certificate is a true, complete, and accurate copy
          of the resolutions of the Board of Directors of the Borrower (or a
          unanimous consent of directors in lieu thereof) authorizing the
          execution, delivery, and performance of this Agreement, the other Loan
          Documents, and the transactions contemplated hereby and thereby, and
          that such resolutions have not been amended or modified since the date
          of such certification and are in full force and effect; (B) the
          incumbency, names, and true signatures of the officers of the Borrower
          authorized to sign the Loan Documents to which it is a party; (C) that
          attached to the Secretary's Certificate is a true and correct copy of
          the Articles or Certificate of Incorporation of the Company, as
          amended, which Articles or Certificate of Incorporation have not been
          further modified, repealed or rescinded and are in full force and
          effect; (D) that attached to the Secretary's Certificate of the
          Borrower is a true and correct copy of the Bylaws, as amended, which
          Bylaws of the Company have not been further modified, repealed or
          rescinded and are in full force and effect; and (E) that attached to
          the Secretary's Certificate is a valid Certificate of Good Standing
          issued by the Secretary of the State of the Borrower's state of
          incorporation;

               (x) the opinion of counsel for the Borrower covering such matters
          incident to the transactions contemplated by this Agreement as the
          Lender may reasonably require;

                                       6
<PAGE>

               (xi) evidence of the consent or authorization of, filing with or
          other act by or in respect of any governmental agency or authority or
          any other Person required in connection with the execution, delivery,
          performance, validity or enforceability of this Agreement, or the
          other Loan Documents or the consummation of the transactions
          contemplated hereby or thereby; and

               (xii) such other documents, agreements and instruments as the
          Lender deems necessary in its sole and absolute discretion in
          connection with the transactions contemplated hereby.

          (b) The security interests in the Collateral granted in favor of the
     Lender under this Agreement shall have been duly perfected and shall
     constitute first priority liens, except for Permitted Liens.

          SECTION 3.4. ADDITIONAL CONDITIONS PRECEDENT. The obligation of the
     Lender to make the Loan is subject to the satisfaction of the following
     additional conditions precedent:

          (a) There shall be no pending or, to the knowledge of the Borrower
     after due inquiry, threatened litigation, proceeding, inquiry, or other
     action (i) seeking an injunction or other restraining order, damages, or
     other relief with respect to the transactions contemplated by this
     Agreement or the other Loan Documents or thereby or (ii) which affects or
     could affect the business, prospects, operations, assets, liabilities, or
     condition (financial or otherwise) of the Borrower, except, in the case of
     clause (ii), where such litigation, proceeding, inquiry, or other action
     could not be expected to have a Material Adverse Effect in the judgment of
     the Lender;

          (b) all representations and warranties contained in this Agreement and
     the other Loan Documents shall be true and correct on and as of the date of
     such Loan as if then made, other than representations and warranties that
     expressly relate solely to an earlier date, in which case they shall have
     been true and correct as of such earlier date;

          (c) No Event of Default or event which with the giving of notice or
     the passage of time, or both, would constitute an Event of Default shall
     have occurred and be continuing or would result from the making of the
     requested Loan as of the date of such request; and

          (d) the Borrower shall be deemed to have hereby reaffirmed and
     ratified all security interests, liens, and other encumbrances heretofore
     granted by the Borrower to the Lender.

          SECTION 3.5. INTEREST RATE; REPAYMENT. The interest rate applicable to
     the Loan made by the Lender hereunder, and the repayment date for such
     Loan, are as set forth in the Note evidencing such Loan.

     SECTION 4. REPRESENTATIONS AND WARRANTIES.

          SECTION 4.1. GOOD STANDING; QUALIFIED TO DO BUSINESS. The Borrower (a)
     is duly organized, validly existing, and in good standing under the laws of
     the State of its

                                       7
<PAGE>

     organization, (b) has the power and authority to own its properties and
     assets and to transact the businesses in which it is presently, or proposes
     to be, engaged, and (c) is duly qualified and authorized to do business and
     is in good standing in every jurisdiction in which the failure to be so
     qualified could have a Material Adverse Effect on (i) the Borrower, (ii)
     the Borrower's ability to perform its obligations under the Loan Documents,
     or (iii) the rights of the Lender hereunder.

          SECTION 4.2. DUE EXECUTION, ETC. The execution, delivery, and
     performance by the Borrower of each of the Loan Documents to which it is a
     party are within the powers of the Borrower, do not contravene the
     organizational documents, if any, of the Borrower, and do not (a) violate
     any law or regulation, or any order or decree of any court or governmental
     authority, (b) conflict with or result in a breach of, or constitute a
     default under, any material indenture, mortgage, or deed of trust or any
     material lease, agreement, or other instrument binding on the Borrower or
     any of its properties, or (c) require the consent, authorization by, or
     approval of or notice to or filing or registration with any governmental
     authority or other Person, except as may be set forth in the Schedule. This
     Agreement is, and each of the other Loan Documents to which the Borrower is
     or will be a party, when delivered hereunder or thereunder, will be, the
     legal, valid, and binding obligation of the Borrower enforceable against
     the Borrower in accordance with its terms, except as enforceability may be
     limited by bankruptcy, insolvency, or similar laws affecting creditors'
     rights generally and by general principles of equity.

          SECTION 4.3. SOLVENCY; NO LIENS. The Borrower is Solvent and will be
     Solvent upon the completion of all transactions contemplated to occur
     hereunder (including, without limitation, the Loan to be made on the
     Effective Date); the security interests granted herein constitute and shall
     at all times constitute the first and only liens on the Collateral other
     than Permitted Liens; and the Borrower is, or will be at the time
     additional Collateral is acquired by it, the absolute owner of the
     Collateral with full right to pledge, sell, consign, transfer, and create a
     security interest therein, free and clear of any and all claims or liens in
     favor of any other Person other than Permitted Liens.

          SECTION 4.4. NO JUDGMENTS, LITIGATION. No judgments are outstanding
     against the Borrower nor is there now pending or, to the best of the
     Borrower's knowledge, threatened any litigation, contested claim, or
     governmental proceeding by or against the Borrower except judgments and
     pending or threatened litigation, contested claims, and governmental
     proceedings which would not, in the aggregate, have a Material Adverse
     Effect on the Borrower.

          SECTION 4.5. NO DEFAULTS. The Borrower is not in default or has not
     received a notice of default under any material contract, lease, or
     commitment to which it is a party or by which it is bound. The Borrower
     knows of no dispute regarding any contract, lease, or commitment which
     could have a Material Adverse Effect on the Borrower.

          SECTION 4.6. COLLATERAL LOCATIONS. The address of the principal place
     of business and chief executive office of Borrower is, and the books and
     records of Borrower and all of its chattel paper and records relating to
     Collateral are maintained exclusively in the possession of Borrower at, the
     address of Borrower specified in the heading of this Agreement. Borrower
     has places of business, and Collateral is located, only at such address and
     at the

                                       8
<PAGE>

     addresses set forth in the Schedule and at any additional locations
     reported to the Lender as provided in Section 5.7 as to which the Lender
     has taken all necessary action to perfect and protect its security
     interests in the Collateral at any such locations.

          SECTION 4.7. CORPORATE AND TRADE NAMES; FEDERAL TAX ID. During the
     past five years, Borrower has not been known by or used any other
     corporate, trade or fictitious name except for its name as set forth on the
     signature page of this Agreement and the other names specified in the
     Schedule. The Borrower's Federal Tax ID number is as set forth in the
     Schedule.

          SECTION 4.8. NO EVENTS OF DEFAULT. No Event of Default has occurred
     and is continuing nor has any event occurred which, with the giving of
     notice or the passage of time, or both, would constitute an Event of
     Default.

          SECTION 4.9. NO LIMITATION ON LENDER'S RIGHTS. Except as permitted
     herein, none of the Collateral is subject to contractual obligations that
     may restrict or inhibit the Lender's rights or abilities to sell or dispose
     of the Collateral or any part thereof after the occurrence of an Event of
     Default.

          SECTION 4.10. PERFECTION AND PRIORITY OF SECURITY INTEREST. This
     Agreement creates a valid and, upon completion of all required filings of
     financing statements and compliance with applicable law, perfected,
     exclusive, security interest in the Collateral, except for any Permitted
     Liens, securing the payment of all the Obligations.

          SECTION 4.11. INTELLECTUAL PROPERTY. Set forth in the Schedule is a
     complete and accurate list of all patents, trademarks, trade names, service
     marks and copyrights (registered and unregistered), and all applications
     therefor and licenses thereof, of Borrower. Borrower owns or licenses all
     material patents, trademarks, service-marks, logos, tradenames, trade
     secrets, know-how, copyrights, or licenses and other rights with respect to
     any of the foregoing, which are necessary or advisable for the operation of
     its business as presently conducted or proposed to be conducted. To the
     best of its knowledge after due inquiry, Borrower has not infringed any
     patent, trademark, service-mark, tradename, copyright, license or other
     right owned by any other Person by the sale or use of any product, process,
     method, substance, part or other material presently contemplated to be sold
     or used, where such sale or use would reasonably be expected to have a
     Material Adverse Effect and no claim or litigation is pending, or to the
     best of Borrower's knowledge, threatened against or affecting Borrower that
     contests its right to sell or use any such product, process, method,
     substance, part or other material.

          SECTION 4.12. CONSENTS AND FILINGS. No consent, authorization or
     approval of, or filing with or other act by, any shareholders of Borrower
     or any governmental authority or other Person is required in connection
     with the execution, delivery, performance, validity or enforceability of
     this Agreement or any other Loan Document, the consummation of the
     transactions contemplated hereby or thereby or the continuing operations of
     Borrower following such consummation, except (i) those that have been
     obtained or made, (ii) the filing of financing statements under the Code
     and (iii) any necessary filings with U.S. Copyright Office and the U.S.
     Patent and Trademark Office.

                                       9
<PAGE>

          SECTION 4.13. YEAR 2000 COMPLIANCE. The Borrower has (i) initiated a
     review and assessment of all areas within its business and operations that
     could be adversely affected by the "Year 2000 Problem" (that is, the risk
     that computer applications used by the Borrower may be unable to recognize
     and perform properly date-sensitive functions involving certain dates prior
     to and any date after December 31, 1999), (ii) developed a plan and
     timeline for addressing the Year 2000 Problem on a timely basis, and (iii)
     to date, implemented that plan in accordance with that timetable. The
     Borrower reasonably believes that all computer applications that are
     material to its business and operations will on a timely basis be able to
     perform properly date-sensitive functions for all dates before and after
     January 1, 2000 (that is, be "Year 2000 compliant"), except to the extent
     that a failure to do so could not reasonably be expected to have Material
     Adverse Effect.

          SECTION 4.14. TAXES. Borrower has properly completed and timely filed
     all income tax returns it is required to file, and all Taxes, assessments,
     fees and other governmental charges for periods beginning prior to the date
     of this Agreement have been timely paid (or, if not yet due or being
     disputed in good faith, adequate reserves therefor have been established in
     accordance with GAAP) and Borrower has no liability for Taxes in excess of
     the amounts so paid or reserves so established. No deficiencies for Taxes
     have been claimed, proposed or assessed by any taxing or other governmental
     agency or authority against Borrower and no notice of any tax lien has been
     filed. There are no pending or (to the best knowledge of Borrower)
     threatened audits, investigations or claims for or relating to any
     liability for Taxes and there are no matters under discussion with any
     governmental agency or authority which could result in an additional
     material liability for Taxes.

          SECTION 4.15. FINANCIAL STATEMENTS. Borrower has provided to the
     Lender complete and accurate Financial Statements, which have been prepared
     in accordance with GAAP (except for the absence of footnotes and subject to
     normal year-end adjustments with respect to unaudited financial statements)
     consistently applied throughout the periods involved and fairly present the
     financial position and results of operations of Borrower for each of the
     periods covered, subject, in the case of any quarterly financial
     statements, to normal year-end adjustments and the absence of notes.
     Borrower has no Contingent Obligation or liability for Taxes, unrealized
     losses, unusual forward or long-term commitments or long-term leases, which
     is not reflected in such Financial Statements or the footnotes thereto.
     Since the last date covered by such Financial Statements, there has been no
     sale, transfer or other disposition by Borrower of any material part of its
     business or property and no purchase or other acquisition of any business
     or property (including any capital stock of any other Person) material in
     relation to the financial condition of Borrower at said date. Since said
     date, (i) there has been no change, occurrence, development or event which
     has had or could reasonably be expected to have a Material Adverse Effect
     and (ii) no material portion of the capital stock of Borrower has been
     redeemed, retired, purchased or otherwise acquired for value by Borrower.

          SECTION 4.16. ACCURACY AND COMPLETENESS OF INFORMATION. All data,
     reports, and information heretofore, contemporaneously, or hereafter
     furnished by or on behalf of the Borrower in writing to the Lender or for
     purposes of or in connection with this Agreement or any other Loan
     Document, or any transaction contemplated hereby or thereby, are or will be
     true and accurate in all material respects on the date as of which such
     data, reports, and information are dated or certified and not incomplete by
     omitting to state any material fact necessary to make

                                       10
<PAGE>

     such data, reports, and information not misleading at such time. There are
     no facts now known to the Borrower which individually or in the aggregate
     would reasonably be expected to have a Material Adverse Effect and which
     have not been specified herein, in the Financial Statements, or in any
     certificate, opinion, or other written statement previously furnished by
     the Borrower to the Lender.

     SECTION 5. COVENANTS OF THE BORROWER.

          SECTION 5.1. EXISTENCE, ETC. The Borrower shall: (a) retain its
     existence and its current yearly accounting cycle, (b) maintain in full
     force and effect all licenses, bonds, franchises, leases, trademarks,
     patents, contracts, and other rights necessary or desirable to the
     profitable conduct of its business unless the failure to do so could not
     reasonably be expected to have a Material Adverse Effect on the Borrower,
     (c) continue in, and limit its operations to, substantially the same
     general lines of business as those presently conducted by it, and (d)
     comply with all applicable laws and regulations of any federal, state, or
     local governmental authority, except for such laws and regulations the
     violations of which would not, in the aggregate, have a Material Adverse
     Effect on the Borrower.

          SECTION 5.2. NOTICE TO THE LENDER. As soon as possible, and in any
     event within five days after the Borrower learns of the following, the
     Borrower will give written notice to the Lender of the following:

          (a) any proceeding instituted or threatened to be instituted by or
     against the Borrower in any federal, state, local, or foreign court or
     before any commission or other regulatory body (federal, state, local, or
     foreign) involving a sum, together with the sum involved in all other
     similar proceedings, in excess of $50,000 in the aggregate,

          (b) any contract that is terminated or amended and which has had or
     could reasonably be expected to have a Material Adverse Effect on the
     Borrower,

          (c) the occurrence of any Material Adverse Change with respect to the
     Borrower;

          (d) the occurrence of any Event of Default or event or condition
     which, with notice or lapse of time or both, would constitute an Event of
     Default, together with a statement of the action which the Borrower has
     taken or proposes to take with respect thereto;

          (e) of any discovery or determination by Borrower that any computer
     application (including those of its suppliers and vendors) that is material
     to its business and operations will not be Year 2000 compliant on a timely
     basis, except to the extent that such failure could not reasonably be
     expected to have a Material Adverse Effect;

          (f) of any material damage to, the destruction of or any other
     material loss to any Collateral owned or used by Borrower other than any
     such Collateral with a net book value (individually or in the aggregate)
     less than $50,000 or any condemnation, confiscation or other taking, in
     whole or in part, or any event that otherwise diminishes so as to render
     impracticable or unreasonable the use of such Collateral owned or used by
     Borrower together with the amount of the damage, destruction, loss or
     diminution in value;

                                       11
<PAGE>

          (g) of any copyright registration made by it, any rights Borrower may
     obtain to any copyrightable works, new trademarks or any new patentable
     inventions, and of any renewal or extension of any trademark registration,
     or if it shall otherwise become entitled to the benefit of any patent or
     patent application or trademark or trademark application; and

          (h) of the opening of any new bank account or other deposit account,
     and any new securities account.

          SECTION 5.3. MAINTENANCE OF BOOKS AND RECORDS. Borrower shall (i)
     maintain books and records (including computer records) pertaining to the
     Collateral in such detail, form and scope as is customary for companies in
     similar businesses in similar situations and (ii) provide the Lender and
     its agents access to the premises of Borrower at any time and from time to
     time, during normal business hours and upon reasonable notice under the
     circumstances, and at any time on and after the occurrence and during the
     existence of an Event of Default, or event or condition which, with notice
     or lapse of time or both, would constitute an Event of Default, for the
     purposes of (A) inspecting and verifying the Collateral, (B) inspecting and
     copying (at Borrower's expense) any and all records pertaining thereto, and
     (C) discussing the affairs, finances and business of Borrower with any
     officer, employee or director of Borrower or with Borrower's accountants.
     Upon the occurrence and continuance of an Event of Default, Borrower shall
     reimburse the Lender for the reasonable travel and related expenses of the
     Lender's employees or, at the Lender's option, of such outside accountants
     or examiners as may be retained by the Lender to verify or inspect
     Collateral, records or documents of Borrower on a regular basis or for a
     special inspection if the Lender deems the same appropriate. If the
     Lender's own employees are used, Borrower shall also pay therefor $600 per
     person per day (or such other amount as shall represent the Lender's then
     current standard charge for the same), or, if outside examiners or
     accountants are used, Borrower shall also pay the Lender such reasonable
     sum as the Lender may be obligated to pay as fees therefor.

          SECTION 5.4. INSURANCE. Borrower shall maintain public liability
     insurance, business interruption insurance, third party property damage
     insurance and replacement value insurance on its assets (including the
     Collateral) under such policies of insurance, with such insurance
     companies, in such amounts and covering such risks as are at all times
     reasonably satisfactory to the Lender in its commercially reasonable
     judgment, all of which policies covering the Collateral shall name the
     Lender as an additional insured and lender loss payee in case of loss, and
     contain other provisions as the Lender may reasonably require to protect
     fully the Lender's interest in the Collateral and any payments to be made
     under such policies.

          SECTION 5.5. TAXES. The Borrower will pay, when due, all taxes,
     assessments, claims, and other charges ("Taxes") lawfully levied or
     assessed against the Borrower or the Collateral other than taxes that are
     being diligently contested in good faith by the Borrower by appropriate
     proceedings promptly instituted and for which an adequate reserve is being
     maintained by the Borrower in accordance with GAAP. If any Taxes remain
     unpaid after the date fixed for the payment thereof, or if any lien shall
     be claimed therefor, then, without notice to the Borrower, but on the
     Borrower's behalf, the Lender may pay such Taxes, and the amount thereof
     shall be included in the Obligations.

                                       12
<PAGE>

          SECTION 5.6. BORROWER TO DEFEND COLLATERAL AGAINST CLAIMS; FEES ON
     COLLATERAL. The Borrower will defend the Collateral against all claims and
     demands of all Persons at any time claiming the same or any interest
     therein except with respect to Persons holding Permitted Liens and their
     agents. The Borrower will not permit any notice creating or otherwise
     relating to liens on the Collateral or any portion thereof to exist or be
     on file in any public office other than Permitted Liens. The Borrower shall
     promptly pay, when payable, all transportation, storage, and warehousing
     charges and license fees, registration fees, assessments, charges, permit
     fees, and taxes (municipal, state, and federal) which may now or hereafter
     be imposed upon the ownership, leasing, renting, possession, sale, or use
     of the Collateral, other than taxes on or measured by the Lender's income
     and fees, assessments, charges, and taxes which are being contested in good
     faith by appropriate proceedings diligently conducted and with respect to
     which adequate reserves are maintained to the extent required by GAAP.

          SECTION 5.7. CHANGE OF LOCATION, STRUCTURE, OR IDENTITY. The Borrower
     will give Lender at least 30 days prior written notice of any change of
     Borrower's chief executive office or of the opening of any additional place
     of business. The Borrower will not move or permit the movement of any item
     of Collateral from the locations specified in the Schedule, except that the
     Borrower keep Collateral at other locations within the United States
     provided that the Borrower has delivered to the Lender (i) prior written
     notice thereof and (ii) duly executed financing statements and other
     agreements and instruments (all in form and substance satisfactory to the
     Lender) necessary or, in the opinion of the Lender, desirable to perfect
     and maintain in favor of the Lender a security interest in the Collateral,
     subject only to Permitted Liens. Notwithstanding anything to the contrary
     in the immediately preceding sentence, the Borrower may keep any Collateral
     consisting of motor vehicles or rolling stock at any location in the United
     States provided that the Lender's security interest in any such Collateral
     is conspicuously marked on the certificate of title thereof and the
     Borrower has complied with the provisions of Section 5.9.

          SECTION 5.8. USE OF COLLATERAL; LICENSES; REPAIR. The Collateral shall
     be operated by competent, qualified personnel in connection with the
     Borrower's business purposes, for the purpose for which the Collateral was
     designed and in accordance with applicable operating instructions, laws,
     and government regulations, and the Borrower shall use every reasonable
     precaution to prevent loss or damage to the Collateral from fire and other
     hazards. The Borrower shall procure and maintain in effect all orders,
     licenses, certificates, permits, approvals, and consents required by
     federal, state, or local laws or by any governmental body, agency, or
     authority in connection with the delivery, installation, use, and operation
     of the Collateral.

          SECTION 5.9. FURTHER ASSURANCES. The Borrower will, promptly upon
     request by the Lender, execute and deliver or use its best efforts to
     obtain any document required by the Lender (including, without limitation,
     warehouseman or processor disclaimers, mortgagee waivers, landlord
     disclaimers, or subordination agreements with respect to the Obligations
     and the Collateral), give any notices, execute and file any financing
     statements, mortgages, or other documents (all in form and substance
     satisfactory to the Lender), mark any chattel paper, deliver any chattel
     paper or instruments to the Lender, and take any other actions that are
     necessary or, in the opinion of the Lender, desirable to perfect or
     continue the perfection and the first priority of the Lender's security
     interest in the Collateral, to protect the Collateral against the rights,

                                       13
<PAGE>

     claims, or interests of any Persons, or to effect the purposes of this
     Agreement. The Borrower hereby authorizes the Lender to file one or more
     financing or continuation statements, and amendments thereto, relating to
     all or any part of the Collateral without the signature of the Borrower
     where permitted by law. A carbon, photographic, or other reproduction of
     this Agreement or any financing statement covering the Collateral or any
     part thereof shall be sufficient as a financing statement where permitted
     by law. To the extent required under this Agreement, the Borrower will pay
     all costs incurred in connection with any of the foregoing.

          SECTION 5.10. NO DISPOSITION OF COLLATERAL. The Borrower will not in
     any way hypothecate or create or permit to exist any lien, security
     interest, charge, or encumbrance on or other interest in any of the
     Collateral, except for the lien and security interest granted hereby and
     Permitted Liens. In the event the Collateral, or any part thereof, is sold,
     transferred, assigned, exchanged, or otherwise disposed of in violation of
     this Agreement, the security interest of the Lender shall continue in such
     Collateral or part thereof notwithstanding such sale, transfer, assignment,
     exchange, or other disposition, and the Borrower will hold the proceeds
     thereof in a separate account for the benefit of the Lender. Following such
     a sale, the Borrower will transfer such proceeds to the Lender in kind.

          SECTION 5.11. NO LIMITATION ON LENDER'S RIGHTS. The Borrower will not
     enter into any contractual obligations from the date hereof which may
     restrict or inhibit the Lender's rights or ability to sell or otherwise
     dispose of the Collateral or any part thereof.

          SECTION 5.12. PROTECTION OF COLLATERAL. Upon notice to the Borrower
     (provided that if an Event of Default has occurred and is continuing the
     Lender need not give any notice), the Lender shall have the right at any
     time to make any payments and do any other acts the Lender may deem
     necessary to protect its security interests in the Collateral, including,
     without limitation, the rights to satisfy, purchase, contest, or compromise
     any encumbrance, charge, or lien which, in the reasonable judgment of the
     Lender, appears to be prior to or superior to the security interests
     granted hereunder, and appear in, and defend any action or proceeding
     purporting to affect its security interests in, or the value of, any of the
     Collateral. The Borrower hereby agrees to reimburse the Lender for all
     payments made and expenses incurred under this Agreement including fees,
     expenses, and disbursements of attorneys and paralegals (including the
     allocated costs of in-house counsel) acting for the Lender, including any
     of the foregoing payments under, or acts taken to protect its security
     interests in, any of the Collateral, which amounts shall be secured under
     this Agreement, and agrees it shall be bound by any payment made or act
     taken by the Lender hereunder absent the Lender's gross negligence or
     willful misconduct. The Lender shall have no obligation to make any of the
     foregoing payments or perform any of the foregoing acts.

          SECTION 5.13. DELIVERY OF ITEMS. The Borrower will (a) promptly (but
     in no event later than one Business Day) after its receipt thereof, deliver
     to the Lender or its agent any documents issued with respect to any
     property included in the Collateral, and any promissory notes, letters of
     credit or instruments related to or otherwise in connection with any
     property included in the Collateral, which in any such case come into the
     possession of the Borrower, or shall cause the issuer thereof to deliver
     any of the same directly to the Lender, in each case with any necessary
     endorsements in favor of the Lender and (b) deliver to the Lender as soon
     as available copies of any and all press releases and other similar
     communications issued by the Borrower.

                                       14
<PAGE>

          SECTION 5.14. SOLVENCY. The Borrower shall be and remain Solvent at
     all times.

          SECTION 5.15. INTELLECTUAL PROPERTY. Borrower shall do and cause to be
     done all things necessary to preserve, maintain and keep in full force and
     effect all of its registrations of trademarks, service marks and other
     marks, trade names and other trade rights, patents, copyrights and other
     intellectual property in accordance with prudent business practices, except
     to the extent that the failure to preserve or maintain any of the foregoing
     would not reasonably be expected to have a Material Adverse Effect. Without
     limiting the generality of the foregoing, Borrower agrees promptly, and in
     any event not later than 30 days after the date hereof, to have any of its
     currently unregistered copyrightable software, computer programs and other
     materials registered with the U.S. Copyright Office in Washington, D.C.
     (the "Copyright Office") and to promptly provide TBCC with evidence of such
     registration. Borrower will, on an ongoing basis, promptly register any
     future unregistered copyrightable software, computer programs and other
     materials with the Copyright Office.

          SECTION 5.16. FUNDAMENTAL CHANGES. The Borrower shall not (a) amend or
     modify its name, unless the Borrower delivers to the Lender thirty days
     prior to any such proposed amendment or modification written notice of such
     amendment or modification and within ten days before such amendment or
     modification delivers executed Uniform Commercial Code financing statements
     (in form and substance satisfactory to the Lender) or (b) merge or
     consolidate with any other entity or make any material change in its
     capital structure, except the issuance of stock shall not be considered a
     change in capital structure, in each case without the Lender's prior
     written consent which shall not be unreasonably withheld.

          SECTION 5.17. CONTINGENT OBLIGATIONS. Borrower will not, directly or
     indirectly, incur, assume, or suffer to exist any Contingent Obligation,
     excluding indemnities given in connection with this Agreement or the other
     Loan Documents in favor of the Lender or in connection with the sale of
     inventory or other asset dispositions permitted hereunder, except
     Contingent Obligations and other similar third party credit support
     relating to obligations of vendors and suppliers of Borrower in respect of
     transactions entered into in the normal course of business, provided that
     the aggregate amount of any such guarantees and other similar third party
     credit support shall not exceed $100,000 at any time outstanding, and
     provided further that no Default or Event of Default shall exist either
     immediately prior to or after giving effect to the making of the foregoing
     guarantees or the entering into any third party credit support
     transactions.

          SECTION 5.18. CHANGE IN NATURE OF BUSINESS. Borrower will not at any
     time make any material change in the lines of its business as carried on at
     the date of this Agreement or enter into any new line of business; provided
     that Borrower may enter businesses reasonably related or incidental to its
     current lines of business.

          SECTION 5.19. SALES OF ASSETS. Borrower will not, directly or
     indirectly, in any fiscal year, sell, transfer or otherwise dispose of any
     assets, or grant any option or other

                                       15
<PAGE>

     right to purchase or otherwise acquire any assets other than (1) equipment
     with an aggregate value of less than $100,000 the proceeds of which shall
     be paid to the Lender and applied to the Obligations unless substituted
     with for other Collateral of equal value, (ii) sales of inventory in the
     ordinary course of business and (iii) licenses or sublicenses on a
     non-exclusive or exclusive basis of intellectual property in the ordinary
     course of Borrower's business, and provided it is in the best interest of
     the Borrower.

          SECTION 5.20. LOANS TO OTHER PERSONS. Borrower will not at any time
     make loans or advance any credit (except to trade debtors in the ordinary
     course of business) to any Person in excess of $100,000 in the aggregate at
     any time for all such loans, except that Borrower may make cashless
     advances of credit to senior members of Borrower's management team to
     purchase restricted stock of Borrower.

          SECTION 5.21. DIVIDENDS, STOCK REDEMPTIONS. Borrower will not,
     directly or indirectly, pay any dividends or distributions on, purchase,
     redeem or retire any shares of any class of its capital stock or any
     warrants, options or rights to purchase any such capital stock, whether now
     or hereafter outstanding ("Stock"), or make any payment on account of or
     set apart assets for a sinking or other analogous fund for, the purchase,
     redemption, defeasance, retirement or other acquisition of its Stock, or
     make any other distribution in respect thereof, either directly or
     indirectly, whether in cash or property or in obligations of Borrower,
     except for dividends paid solely in stock of the Borrower and repurchases
     of stock owned by employees, directors and consultants of Borrower pursuant
     to terms of employment, consulting or other stock restrictions agreements
     at such time as any such employee, director or consultant terminates his or
     her affiliations with the Borrower, provided that no Default or Event of
     Default shall exist either immediately prior to or after giving effect to
     such repurchase, and provided further that the total amount paid in
     connection therewith by Borrower shall not exceed $50,000 in any
     consecutive 12-month period.

          SECTION 5.22. INVESTMENTS IN OTHER PERSONS. Borrower will not,
     directly or indirectly, at any time make or hold any Investment in any
     Person (whether in cash, securities or other property of any kind) other
     than investments in Cash Equivalents, without the Lender's prior written
     consent which shall not be unreasonably withheld.

          SECTION 5.23. ACQUISITION OF STOCK OR ASSETS. Borrower will not
     acquire or commit or agree to acquire all or any stock, securities or
     assets of any other Person other than inventory and equipment acquired in
     the ordinary course of business, without the Lender's prior written consent
     which shall not be unreasonably withheld.

          SECTION 5.24. PARTNERSHIPS; SUBSIDIARIES; JOINT VENTURES; MANAGEMENT
     CONTRACTS. Borrower will not at any time create any direct or indirect
     Subsidiary, enter into any joint venture or similar arrangement (other than
     joint ventures or strategic partnerships consisting of non-exclusive or
     exclusive licensing of technology or the providing of technical support or
     subsidiaries or affiliates, the assets of which include a portion of
     Borrower's technology) or become a partner in any general or limited
     partnership or enter into any management contract (other than an employment
     contract for the employment of an officer or employee entered into in the
     regular course of Borrower's business) permitting third party management
     rights with respect to Borrower's business.

                                       16
<PAGE>

          SECTION 5.25. ADDITIONAL REQUIREMENTS. The Borrower shall take all
     such further actions and execute all such further documents and instruments
     as the Lender may reasonably request.

     SECTION 6. FINANCIAL STATEMENTS. Until the payment and satisfaction in
     full of all Obligations, the Borrower shall deliver to the Lender the
     following financial information:

          SECTION 6.1. ANNUAL FINANCIAL STATEMENTS. As soon as available, but
     not later than 90 days after the end of each fiscal year of the Borrower
     and its consolidated subsidiaries, the consolidated balance sheet, income
     statement, and statements of cash flows and shareholders equity for the
     Borrower and its consolidated subsidiaries (the "Financial Statements") for
     such year, reported on by independent certified public accountants without
     an adverse qualification; and

          SECTION 6.2. QUARTERLY FINANCIAL STATEMENTS. As soon as available, but
     not later than 30 days after the end of each of the first three fiscal
     quarters in any fiscal year of the Borrower and its consolidated
     subsidiaries, the Financial Statements for such fiscal quarter, together
     with a certification duly executed by a responsible officer of the Borrower
     that such Financial Statements have been prepared in accordance with GAAP
     and are fairly stated in all material respects (subject to normal year-end
     audit adjustments).

     SECTION 7. EVENTS OF DEFAULT. The occurrence of any of the following events
shall constitute an Event of Default hereunder:

               (a) the Borrower shall fail to pay when due any principal,
          interest, fee or other amount required to be paid by the Borrower
          under or in connection with any Note and this Agreement;

               (b) any representation or warranty made or deemed made by the
          Borrower under or in connection with any Loan Document or any
          Financial Statement shall prove to have been false or incorrect in any
          material respect when made or deemed made;

               (c) the Borrower shall fail to perform or observe (i) any of the
          terms, covenants or agreements contained in Sections 5.4, 5.7, 5.10,
          5.14 or 5.16 through 5.25 hereof or (ii) any other term, covenant, or
          agreement contained in any Loan Document (other than the other Events
          of Default specified in this Section 7) and such failure remains
          unremedied for the earlier of ten days from (A) the date on which the
          Lender has given the Borrower written notice of such failure and (B)
          the date on which the Borrower knew or should have known of such
          failure;

               (d) any defined "Event of Default" shall occur under any other
          Loan Document; or Borrower or any Person shall deny or disaffirm its
          obligations under any of the Loan Documents or any Liens granted in
          connection therewith or shall otherwise challenge any of its
          obligations under any of the Loan Documents; or any Liens granted in
          any of the Collateral shall be determined to be void, voidable or
          invalid, are subordinated or are not given the priority contemplated
          by this Agreement; or any Loan Document shall for any reason cease to
          create a valid and perfected Lien on the Collateral purported to be
          covered thereby, of first priority (except for Permitted Liens);

                                       17
<PAGE>

               (e) dissolution, liquidation, winding up, or cessation of the
          Borrower's business, failure of the Borrower generally to pay its
          debts as they mature, admission in writing by the Borrower of its
          inability generally to pay its debts as they mature, or calling of a
          meeting of the Borrower's creditors for purposes of compromising any
          of the Borrower's debts;

               (f) the commencement by or against the Borrower of any
          bankruptcy, insolvency, arrangement, reorganization, receivership, or
          similar proceedings under any federal or state law and, in the case of
          any such involuntary proceeding, such proceeding remains undismissed
          or unstayed for sixty days following the commencement thereof, or any
          action by the Borrower is taken authorizing any such proceedings;

               (g) an assignment for the benefit of creditors is made by the
          Borrower, whether voluntary or involuntary, the appointment of a
          trustee, custodian, receiver, or similar official for the Borrower or
          for any substantial property of the Borrower, or any action by the
          Borrower authorizing any such proceeding;

               (h) the Borrower shall default in (i) the payment of principal or
          interest on any indebtedness in excess of $100,000 (other than the
          Obligations) beyond the period of grace, if any, provided in the
          instrument or agreement under which such indebtedness was created, and
          such payment default has not been cured within any applicable grace
          period unless such default has been waived by such Person; or (ii) the
          observance or performance of any other agreement or condition relating
          to any such indebtedness or contained in any instrument or agreement
          relating thereto, or any other event shall occur or condition exist,
          the effect of which default or other event or condition is to cause,
          or to permit the holder or holders of such indebtedness to cause, with
          the giving of notice if required, such indebtedness to become due
          prior to its stated maturity, and such default has not been cured
          within any applicable grace period unless such default has been waived
          by such Person; or (iii) any loan or other agreement under which the
          Borrower has received financing from Transamerica Corporation or any
          of its affiliates;

               (i) the Borrower suffers or sustains a Material Adverse Change;

               (j) any tax lien, other than a Permitted Lien, is filed of record
          against the Borrower and is not bonded or discharged within thirty
          Business Days after Borrower has received notice of any such lien;

               (k) any judgment or order for the payment of money in excess of
          $50,000 and not otherwise covered by applicable insurance shall be
          rendered against the Borrower and such judgment or order shall not be
          stayed, vacated, bonded, or discharged within thirty days;

               (l) any material covenant, agreement, or obligation, as
          determined in the sole discretion of the Lender, made by the Borrower
          and contained in or evidenced by any of the Loan Documents shall cease
          to be enforceable, or shall be determined to be unenforceable, in
          accordance with its terms; the Borrower shall deny or disaffirm the
          Obligations under any of the Loan Documents or any liens granted in
          connection therewith; or any liens granted on any

                                       18
<PAGE>

          material portion of the Collateral in favor of the Lender shall be
          determined to be void, voidable, or invalid, or shall not be given the
          priority contemplated by this Agreement.

               (m) there is a change, which change results from a single
          transaction or series of related transactions, but not from the sale
          of newly issued securities to investors, in more than 35% of the
          ownership of any equity interests of the Borrower on the date hereof
          or more than 35% of such interests become subject to any contractual,
          judicial, or statutory lien, charge, security interest, or encumbrance
          and Borrower has prior knowledge of such contractual, judicial or
          statutory lien, charge, security interest or encumbrance.

     SECTION 8. REMEDIES. If any Event of Default shall have occurred and be
continuing:

               (a) The Lender may, without prejudice to any of its other rights
          under any Loan Document or Applicable Law, declare all Obligations to
          be immediately due and payable (except with respect to any Event of
          Default set forth in Section 7(f) hereof, in which case all
          Obligations shall automatically become immediately due and payable
          without necessity of any declaration) without presentment,
          representation, demand of payment, or protest, which are hereby
          expressly waived.

               (b) The Lender may take possession of the Collateral and, for
          that purpose may enter, with the aid and assistance of any person or
          persons, any premises where the Collateral or any part hereof is, or
          may be placed, and remove the same.

               (c) The obligation of the Lender, if any, to make additional
          Loans or financial accommodations of any kind to the Borrower shall
          immediately terminate.

               (d) The Lender may exercise in respect of the Collateral, in
          addition to other rights and remedies provided for herein (or in any
          Loan Document) or otherwise available to it, all the rights and
          remedies of a secured party under the applicable Uniform Commercial
          Code (the "Code") whether or not the Code applies to the affected
          Collateral and also may (i) require the Borrower to, and the Borrower
          hereby agrees that it will at its expense and upon request of the
          Lender forthwith, assemble all or part of the Collateral as directed
          by the Lender and make it available to the Lender at a place to be
          designated by the Lender that is reasonably convenient to both parties
          and (ii) without notice except as specified below, sell the Collateral
          or any part thereof in one or more parcels at public or private sale,
          at any of the Lender's offices or elsewhere, for cash, on credit, or
          for future delivery, and upon such other terms as the Lender may deem
          commercially reasonable.

               (e) The Lender may accelerate or extend the time of payment,
          compromise, issue credits, or bring suit on all accounts receivable
          ("Receivables") and other Collateral (in the name of Borrower or the
          Lender) and otherwise administer and collect the Receivables and other
          Collateral.

               (f) The Lender may collect, receive, dispose of and realize upon
          any investment property Collateral, including withdrawal of any and
          all funds from any securities accounts.

                                       19
<PAGE>

               (g) The Lender may (i) settle or adjust disputes or claims
          directly with account debtors for amounts and upon terms which it
          considers advisable, and (ii) notify account debtors on the
          Receivables and other Collateral that the Receivables and Collateral
          have been assigned to the Lender, and that payments in respect thereof
          shall be made directly to the Lender. If an Event of Default has
          occurred and is continuing, Borrower hereby irrevocably authorizes and
          appoints the Lender, or any Person the Lender may designate, as its
          attorney-in-fact, at Borrower's sole cost and expense, to exercise,
          all of the following powers, which are coupled with an interest and
          are irrevocable, until all of the Obligations have been indefeasibly
          paid and satisfied in full in cash: (A) to receive, take, endorse,
          sign, assign and deliver, all in the name of the Lender or Borrower,
          any and all checks, notes, drafts, and other documents or instruments
          relating to the Collateral; (B) to receive, open and dispose of all
          mail addressed to Borrower; and (C) to take or bring, in the name of
          the Lender or Borrower, all steps, actions, suits or proceedings
          deemed by the Lender necessary or desirable to enforce or effect
          collection of Receivables and other Collateral or file and sign
          Borrower's name on a proof of claim in bankruptcy or similar document
          against any obligor of Borrower.

               (h) The Borrower agrees that, to the extent notice of sale shall
          be required by law, at least ten days' notice to the Borrower of the
          time and place of any public sale or the time after which any private
          sale is to be made shall constitute reasonable notification. The
          Lender shall not be obligated to make any sale of Collateral
          regardless of notice of sale having been given. The Lender may adjourn
          any public or private sale from time to time by announcement at the
          time and place fixed therefor, and such sale may, without further
          notice, be made at the time and place to which it was so adjourned.
          Borrower recognizes that the Lender may be unable to make a public
          sale of any or all of any investment property Collateral, by reason of
          prohibitions contained in applicable securities laws or otherwise, and
          expressly agrees that a private sale to a restricted group of
          purchasers for investment and not with a view to any distribution
          thereof shall be considered a commercially reasonable sale.

               (i) Unless expressly prohibited by any licensor thereof, the
          Lender is hereby granted a license to use all computer software
          programs, data bases, processes, trademarks, tradenames and materials
          used by Borrower in connection with its businesses or in connection
          with the Collateral.

               (j) All cash proceeds received by the Lender in respect of any
          sale of, collection from, or other realization upon all or any part of
          the Collateral may, in the discretion of the Lender, be held by the
          Lender as collateral for, or then or at any time thereafter applied in
          whole or in part by the Lender against, all or any part of the
          Obligations in such order as the Lender shall elect. Any surplus of
          such cash or cash proceeds held by the Lender and remaining after the
          full and final payment of all the Obligations shall be paid over to
          the Borrower or to such other Person to which the Lender may be
          required under applicable law, or directed by a court of competent
          jurisdiction, to make payment of such surplus.

     SECTION 9. MISCELLANEOUS PROVISIONS.

          SECTION 9.1. NOTICES. Except as otherwise provided herein, all
     notices, approvals, consents, correspondence, or other communications
     required or desired to be given hereunder shall be given in writing and
     shall be delivered by overnight courier, hand delivery, or

                                       20
<PAGE>

     certified or registered mail, postage prepaid, if to the Lender, then to at
     76 Batterson Park Road, Farmington, Connecticut 06032, with a copy to the
     Lender at Riverway II, West Office Tower, 9399 West Higgins Road, Rosemont,
     Illinois 60018, and if to the Borrower, then to Five Science Park, New
     Haven, Connecticut, 06511, Attention: Chief Financial Officer with a copy
     to Robinson & Cole LLP, 280 Trumbull Street, Hartford, CT 06103, Attn:
     Felicia DeDominicis, Esq. or such other address as shall be designated by
     the Borrower or the Lender to the other party in accordance herewith. All
     such notices and correspondence shall be effective when received.

          SECTION 9.2. HEADINGS. The headings in this Agreement are for purposes
     of reference only and shall not affect the meaning or construction of any
     provision of this Agreement.

          SECTION 9.3. ASSIGNMENTS AND PARTICIPATIONS. The Borrower shall not
     have the right to assign any Note or this Agreement or any interest therein
     unless the Lender shall have given the Borrower prior written consent and
     the Borrower and its assignee shall have delivered assignment documentation
     in form and substance satisfactory to the Lender in its sole discretion.
     The Lender may assign (without the consent of Borrower) to one or more
     Persons all or a portion of its rights and obligations under this Agreement
     and the other Loan Documents (provided that such Person shall not be a
     direct or indirect competitor of the Borrower). The Lender may sell
     participations in or to all or a portion of its rights and obligations
     under this Agreement (including, without limitation, all or a portion of
     any Loans); provided, however, that the Lender's obligations under this
     Agreement shall remain unchanged. The Lender may, in connection with any
     permitted assignment or participation or proposed assignment or
     participation pursuant to this Agreement, disclose to the assignee or
     participant or proposed assignee or participant any information relating to
     Borrower furnished to the Lender by or on behalf of Borrower.

          SECTION 9.4. AMENDMENTS, WAIVERS, AND CONSENTS. Any amendment or
     waiver of any provision of this Agreement and any consent to any departure
     by the Borrower from any provision of this Agreement shall be effective
     only by a writing signed by the Lender (and, with respect to any amendment,
     the Borrower) and shall bind and benefit the Borrower and the Lender and
     their respective successors and assigns, subject, in the case of the
     Borrower, to the first sentence of Section 9.3.

          SECTION 9.5. INTERPRETATION OF AGREEMENT. Time is of the essence in
     each provision of this Agreement of which time is an element. All terms not
     defined herein or in a Note shall have the meaning set forth in the
     applicable Code, except where the context otherwise requires. To the extent
     a term or provision of this Agreement conflicts with any Note, or any term
     or provision thereof, and is not dealt with herein with more specificity,
     this Agreement shall control with respect to the subject matter of such
     term or provision. Acceptance of or acquiescence in a course of performance
     rendered under this Agreement shall not be relevant in determining the
     meaning of this Agreement even though the accepting or acquiescing party
     had knowledge of the nature of the performance and opportunity for
     objection.

          SECTION 9.6. CONTINUING SECURITY INTEREST. This Agreement shall create
     a continuing security interest in the Collateral and shall (i) remain in
     full force and effect until the indefeasible payment in full of the
     Obligations, (ii) be binding upon the Borrower and

                                       21
<PAGE>

     its successors and assigns and (iii) inure, together with the rights and
     remedies of the Lender hereunder, to the benefit of the Lender and its
     successors, transferees, and assigns.

          SECTION 9.7. REINSTATEMENT. To the extent permitted by law, this
     Agreement and the rights and powers granted to the Lender hereunder and
     under the Loan Documents shall continue to be effective or be reinstated if
     at any time any amount received by the Lender in respect of the Obligations
     is rescinded or must otherwise be restored or returned by the Lender upon
     the insolvency, bankruptcy, dissolution, liquidation, or reorganization of
     the Borrower or upon the appointment of any receiver, intervenor,
     conservator, trustee, or similar official for the Borrower or any
     substantial part of its assets, or otherwise, all as though such payments
     had not been made.

          SECTION 9.8. SURVIVAL OF PROVISIONS. All representations, warranties,
     and covenants of the Borrower contained herein shall survive the execution
     and delivery of this Agreement, and shall terminate only upon the full and
     final payment and performance by the Borrower of the Obligations secured
     hereby.

          SECTION 9.9. INDEMNIFICATION. The Borrower agrees to indemnify and
     hold harmless the Lender and its directors, officers, agents, employees,
     and counsel from and against any and all costs, expenses, claims, or
     liability incurred by the Lender or such Person hereunder and under any
     other Loan Document or in connection herewith or therewith, unless such
     claim or liability shall be due to willful misconduct or gross negligence
     on the part of the Lender or such Person. In addition and without limiting
     the generality of the foregoing, Borrower shall, upon demand, pay to the
     Lender all reasonable costs and expenses incurred by the Lender (including
     the reasonable fees and disbursements of counsel and other professionals)
     in connection with the preparation, execution, delivery, administration,
     modification and amendment of the Loan Documents, and pay to the Lender all
     reasonable costs and expenses (including the reasonable fees and
     disbursements of counsel and other professionals) paid or incurred by the
     Lender in order to enforce or defend any of its rights under or in respect
     of this Agreement, any other Loan Document or any other document or
     instrument now or hereafter executed and delivered in connection herewith,
     collect the Obligations or otherwise administer this Agreement, foreclose
     or otherwise realize upon the Collateral or any part thereof, prosecute
     actions against, or defend actions by, account debtors; commence, intervene
     in, or defend any action or proceeding; initiate any complaint to be
     relieved of the automatic stay in bankruptcy; file or prosecute any probate
     claim, bankruptcy claim, third-party claim, or other claim; examine, audit,
     copy, and inspect any of the Collateral or any of Borrower's books and
     records; protect, obtain possession of, lease, dispose of, or otherwise
     enforce the Lender's security interest in, the Collateral; and otherwise
     represent the Lender in any litigation relating to Borrower.

          SECTION 9.10. COUNTERPARTS; SIGNATURES BY FACSIMILE. This Agreement
     may be executed in counterparts, each of which when so executed and
     delivered shall be an original, but both of which shall together constitute
     one and the same instrument. This Agreement and each of the other Loan
     Documents and any notices given in connection herewith or therewith may be
     executed and delivered by facsimile transmission all with the same force
     and effect as if the same was a fully executed and delivered original
     manual counterpart.

                                       22
<PAGE>

          SECTION 9.11. SEVERABILITY. In case any provision in or obligation
     under this Agreement or any Note or any other Loan Document shall be
     invalid, illegal, or unenforceable in any jurisdiction, the validity,
     legality, and enforceability of the remaining provisions or obligations, or
     of such provision or obligation in any other jurisdiction, shall not in any
     way be affected or impaired thereby.

          SECTION 9.12. DELAYS; PARTIAL EXERCISE OF REMEDIES. No delay or
     omission of the Lender to exercise any right or remedy hereunder, whether
     before or after the happening of any Event of Default, shall impair any
     such right or shall operate as a waiver thereof or as a waiver of any such
     Event of Default. No single or partial exercise by the Lender of any right
     or remedy shall preclude any other or further exercise thereof, or preclude
     any other right or remedy.

          SECTION 9.13. ENTIRE AGREEMENT. The Borrower and the Lender agree that
     this Agreement, the Schedule hereto, Promissory Note and the Commitment
     Letter are the complete and exclusive statement and agreement between the
     parties with respect to the subject matter hereof, superseding all
     proposals and prior agreements, oral or written, and all other
     communications between the parties with respect to the subject matter
     hereof. Should there exist any inconsistency between the terms of the
     Commitment Letter and this Agreement, the terms of this Agreement shall
     prevail.

          SECTION 9.14. SETOFF. In addition to and not in limitation of all
     rights of offset that the Lender may have under Applicable Law, and whether
     or not the Lender has made any demand or the Obligations of the Borrower
     have matured, the Lender shall have the right to appropriate and apply to
     the payment of the Obligations of the Borrower all deposits and other
     obligations then or thereafter owing by the Lender to or for the credit or
     the account of the Borrower.

          SECTION 9.15. JOINT AND SEVERAL LIABILITY. If Borrower consists of
     more than one Person, their liability shall be joint and several, and the
     compromise of any claim with, or the release of, any Borrower shall not
     constitute a compromise with, or a release of, any other Borrower.

          SECTION 9.16. MAXIMUM RATE. Notwithstanding anything to the contrary
     contained elsewhere in this Agreement or in any other Loan Document, the
     parties hereto hereby agree that all agreements between them under this
     Agreement and the other Loan Documents, whether now existing or hereafter
     arising and whether written or oral, are expressly limited so that in no
     contingency or event whatsoever shall the amount paid, or agreed to be
     paid, to the Lender for the use, forbearance, or detention of the money
     loaned to Borrower and evidenced hereby or thereby or for the performance
     or payment of any covenant or obligation contained herein or therein,
     exceed the maximum non-usurious interest rate, if any, that at any time or
     from time to time may be contracted for, taken, reserved, charged or
     received on the Obligations, under the laws of the State of Illinois (or
     the laws of any other jurisdiction whose laws may be mandatorily applicable
     notwithstanding other provisions of this Agreement and the other Loan
     Documents), or under applicable federal laws which may presently or
     hereafter be in effect and which allow a higher maximum non-usurious
     interest rate than under the laws of the State of Illinois (or such other
     jurisdiction), in any case after taking into account, to the extent
     permitted

                                       23
<PAGE>

     by applicable law, any and all relevant payments or charges under this
     Agreement and the other Loan Documents executed in connection herewith, and
     any available exemptions, exceptions and exclusions (the "Highest Lawful
     Rate"). If due to any circumstance whatsoever, fulfillment of any
     provisions of this Agreement or any of the other Loan Documents at the time
     performance of such provision shall be due shall exceed the Highest Lawful
     Rate, then, automatically, the obligation to be fulfilled shall be modified
     or reduced to the extent necessary to limit such interest to the Highest
     Lawful Rate, and if from any such circumstance the Lender should ever
     receive anything of value deemed interest by applicable law which would
     exceed the Highest Lawful Rate, such excessive interest shall be applied to
     the reduction of the principal amount then outstanding hereunder or on
     account of any other then outstanding Obligations and not to the payment of
     interest, or if such excessive interest exceeds the principal unpaid
     balance then outstanding hereunder and such other then outstanding
     Obligations, such excess shall be refunded to Borrower. All sums paid or
     agreed to be paid to the Lender for the use, forbearance, or detention of
     the Obligations and other indebtedness of Borrower to the Lender shall, to
     the extent permitted by applicable law, be amortized, prorated, allocated
     and spread throughout the full term of such indebtedness, until payment in
     full thereof, so that the actual rate of interest on account of all such
     indebtedness does not exceed the Highest Lawful Rate throughout the entire
     term of such indebtedness. The terms and provisions of this Section shall
     control every other provision of this Agreement, the other Loan Documents
     and all other agreements between the parties hereto.

          SECTION 9.17. WAIVER OF JURY TRIAL. THE BORROWER AND THE LENDER
     IRREVOCABLY WAIVE ALL RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING, OR
     COUNTERCLAIM ARISING OUT OF OR RELATING TO THIS AGREEMENT, ANY OTHER LOAN
     DOCUMENT, OR THE TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY.

          SECTION 9.18. GOVERNING LAW. THE VALIDITY, INTERPRETATION, AND
     ENFORCEMENT OF THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN
     ACCORDANCE WITH THE LAWS OF THE STATE OF ILLINOIS WITHOUT GIVING EFFECT TO
     THE CONFLICT OF LAW PRINCIPLES THEREOF.

          SECTION 9.19. VENUE; SERVICE OF PROCESS. ANY LEGAL ACTION OR
     PROCEEDING WITH RESPECT TO THIS AGREEMENT OR ANY OTHER LOAN DOCUMENT MAY BE
     BROUGHT IN THE COURTS OF THE STATE OF ILLINOIS SITUATED IN COOK COUNTY, OR
     OF THE UNITED STATES OF AMERICA FOR THE NORTHERN DISTRICT OF ILLINOIS, AND,
     BY EXECUTION AND DELIVERY OF THIS AGREEMENT, THE BORROWER HEREBY ACCEPTS
     FOR ITSELF AND IN RESPECT OF ITS PROPERTY, GENERALLY AND UNCONDITIONALLY,
     THE JURISDICTION OF THE AFORESAID COURTS. THE BORROWER HEREBY IRREVOCABLY
     WAIVES, IN CONNECTION WITH ANY SUCH ACTION OR PROCEEDING, (a) ANY
     OBJECTION, INCLUDING, WITHOUT LIMITATION, ANY OBJECTION TO THE LAYING OF
     VENUE OR BASED ON THE GROUNDS OF FORUM NON CONVENIENS, THAT IT MAY NOW OR
     HEREAFTER HAVE TO THE BRINGING OF ANY SUCH ACTION OR PROCEEDING IN SUCH
     RESPECTIVE JURISDICTIONS AND (b) THE RIGHT TO INTERPOSE ANY NONCOMPULSORY
     SETOFF, COUNTERCLAIM, OR CROSS-CLAIM. THE BORROWER

                                       24
<PAGE>

     IRREVOCABLY CONSENTS TO THE SERVICE OF PROCESS OF ANY OF THE AFOREMENTIONED
     COURTS IN ANY SUCH ACTION OR PROCEEDING BY THE MAILING OF COPIES THEREOF BY
     REGISTERED OR CERTIFIED MAIL, POSTAGE PREPAID, TO THE BORROWER AT THE
     ADDRESS FOR IT SPECIFIED IN SECTION 9.1 HEREOF. NOTHING HEREIN SHALL AFFECT
     THE RIGHT OF THE LENDER TO SERVE PROCESS IN ANY OTHER MANNER PERMITTED BY
     LAW OR TO COMMENCE LEGAL PROCEEDINGS OR OTHERWISE PROCEED AGAINST THE
     BORROWER IN ANY OTHER JURISDICTION, SUBJECT IN EACH INSTANCE TO THE
     PROVISIONS HEREOF WITH RESPECT TO RIGHTS AND REMEDIES.

          IN WITNESS WHEREOF, the undersigned Borrower has caused this Agreement
     to be duly executed and delivered by its proper and duly authorized officer
     as of the date first set forth above.

                                             GENAISSANCE PHARMACEUTICALS, INC.

                                             By: /s/ Kevin Rakin
                                                 -----------------------------

                                             Name:   Kevin Rakin
                                                   ---------------------------

                                             Title:  CFO & EVP
                                                    --------------------------

Accepted as of the

______day of April, 1999

TRANSAMERICA BUSINESS CREDIT CORPORATION

By: /s/ Robert Pomeroy
    ---------------------------

Name: Robert Pomeroy
      ---------------------------

Title:
      ---------------------------

                                       25
<PAGE>

                                   SCHEDULE A
                                       TO
                           LOAN AND SECURITY AGREEMENT

<TABLE>
<S>                                                                   <C>
Consents and Approvals (Section 4.2):                                  Connecticut Department of
                                                                       Economic & Community
                                                                       Development

Other Places of Business and Locations of Collateral (Section 4.16):   None

Prior Names of Obligor (Section 4.7):                                  BIOS Laboratories, Inc.

Prior Trade Names of Obligor (Section 4.7):                            None

Existing Trade Names of Obligor (Section 4.7):                         None

Federal Tax ID (Section 4.7):                                          06-1338846

Registered and Unregistered Patents (Section 4.11):                    See Exhibit 4.11(a) hereto

Registered and Unregistered Trademarks (Section 4.11):                 See Exhibit 4.11(b) hereto

Registered Copyrights (Section 4.11):                                  See Exhibit 4.11(c) hereto
</TABLE>

                                       26
<PAGE>

                                 PROMISSORY NOTE
                                    1083-001

                                                            Date: April 30, 1999

     FOR VALUE RECEIVED, the undersigned promises to pay to the order of
Transamerica Business Credit Corporation or its assigns (the "Payee") at its
office located at Riverway II, West Office Tower, 9399 West Higgins Road,
Rosemont, Illinois 60018, or at such other place as the Payee or the holder
hereof may designate in writing, the principal amount of Two Million and 00/100
Dollars ($2,000,000.00) received by the undersigned, plus interest, in lawful
money of the United States and in immediately available funds. Interest only
payments shall be due and payable commencing June 1, 1999 and continuing through
November 1, 1999. Thereafter, interest and principal payments shall be due in 33
consecutive monthly installments of Seventy Two Thousand, Three Hundred Eighty
Eight and 62/100 Dollars ($72,388.62). No amount of principal paid or prepaid
hereunder may be reborrowed.

     This Note is the Note referred to in the Loan and Security Agreement dated
as of April 30, 1999 (as amended, supplemented or otherwise modified from time
to time, the "Agreement"), between the undersigned and the Payee and is subject
and entitled to all provisions and benefits thereof. Capitalized terms used but
not defined herein shall have the meanings set forth in the Agreement.

     If any installment of this Note is not paid within five days after its due
date, the undersigned agrees to pay on demand, in addition to the amount of such
installment, an amount equal to 5% of such installment, but only to the extent
permitted by Applicable Law.

     The undersigned shall have the right to prepay this Note at any time on or
after 180 days from the date hereof, on thirty days' prior written notice to the
Payee. On the date of any such prepayment or the acceleration of the maturity,
the undersigned shall pay an amount equal to the present value of the remaining
payments (principal and interest) due hereunder discounted at 8% simple interest
PER ANNUM, together with all interest, fees and other amounts payable on the
amount so prepaid or in connection therewith to the date of such prepayment. Any
prepayments shall be applied to the installments hereof in the inverse order of
maturity.

     Upon the maturity of this Note, the entire unpaid principal amount on this
Note, together with all interest, fees and other amounts payable hereon or in
connection herewith, shall be immediately due and payable without further notice
or demand, with interest on all such amounts at a rate not to exceed the lawful
limit, from the date of such maturity or acceleration, as the case may be, until
all such amounts have been paid. Upon default or the acceleration of the
maturity of this Note in accordance with the terms of the Agreement, the entire
unpaid principal amount on this Note, together with all interest, fees,
prepayment fees and charges in an amount equal to the present value of the
remaining payments (principal and interest) due hereunder discounted at 6%
simple interest PER ANNUM and other amounts payable hereon or in connection
herewith, shall be immediately due and payable without further notice or demand,
with interest on all such amounts at a rate not to exceed the lawful limit, from
the date of such maturity, default or acceleration, as the case may be, until
all such amounts have been paid.

<PAGE>

     If any payment on this Note becomes payable on a day other than a Business
Day, the maturity thereof shall be extended to the next succeeding Business Day.

     The undersigned hereby waives diligence, demand, presentment, protest and
notice of any kind, and assents to extensions of the time of payment, release,
surrender or substitution of security, or forbearance or other indulgence,
without notice. The undersigned agrees to pay all amounts under this Note
without offset, deduction, claim, counterclaim, defense or recoupment, all of
which are hereby waived.

     The Payee, the undersigned and any other parties to the Loan Documents
intend to contract in strict compliance with applicable usury law from time to
time in effect. In furtherance thereof such Persons stipulate and agree that
none of the terms and provisions contained in the Loan Documents shall ever be
construed to create a contract to pay, for the use, forbearance or detention of
money, interest in excess of the maximum amount of interest permitted to be
charged by Applicable Law from time to time in effect. Neither the undersigned
nor any present or future guarantors, endorsers, or other Persons hereafter
becoming liable for payment of any Obligation shall ever be liable for unearned
interest thereon or shall ever be required to pay interest thereon in excess of
the maximum amount that may be lawfully charged under Applicable Law from time
to time in effect, and the provisions of this paragraph shall control over all
other provisions of the Loan Documents which may be in conflict or apparent
conflict herewith. The Payee expressly disavows any intention to charge or
collect excessive unearned interest or finance charges in the event the maturity
of any Obligation is accelerated. If (a) the maturity of any Obligation is
accelerated for any reason, (b) any Obligation is prepaid and as a result any
amounts held to constitute interest are determined to be in excess of the legal
maximum, or (c) the Payee or any other holder of any or all of the Obligations
shall otherwise collect amounts which are determined to constitute interest
which would otherwise increase the interest on any or all of the Obligations to
an amount in excess of that permitted to be charged by Applicable Law then in
effect, then all sums determined to constitute interest in excess of such legal
limit shall, without penalty, be promptly applied to reduce the then outstanding
principal of the related Obligations or, at the Payee's or such holder's option,
promptly returned to the undersigned upon such determination. In determining
whether or not the interest paid or payable, under any specific circumstance,
exceeds the maximum amount permitted under Applicable Law, the Payee and the
undersigned (and any other payors thereof) shall to the greatest extent
permitted under Applicable Law, (i) characterize any non-principal payment as an
expense, fee or premium rather than as interest, (ii) exclude voluntary
prepayments and the effects thereof, and (iii) amortize, prorate, allocate, and
spread the total amount of interest through the entire contemplated term of this
Note in accordance with the amount outstanding from time to time thereunder and
the maximum legal rate of interest from time to time in effect under Applicable
Law in order to lawfully charge the maximum amount of interest permitted under
Applicable Law.

     This Note may not be changed, modified or terminated orally, but only by an
agreement in writing signed by the undersigned and the Payee or any holder
hereof.

     The undersigned shall, upon demand, pay to the Payee all costs and expenses
incurred by the Payee (including the fees and disbursements of counsel and other
professionals) in connection with the preparation, execution and delivery of
this Note and all other Loan

                                       2
<PAGE>

Documents, and in connection with the administration, modification and amendment
of the Loan Documents, and pay to the Payee all costs and expenses (including
the fees and disbursements of counsel and other professionals) paid or incurred
by the Payee in (A) enforcing or defending its rights under or in respect of
this Note or any of the other Loan Documents, (B) collecting any of the
liabilities by the undersigned to the Payee or otherwise administering the Loan
Documents, (C) foreclosing or otherwise collecting upon any collateral and (D)
obtaining any legal, accounting or other advice in connection with any of the
foregoing.

     This Note shall be binding upon the successors and assigns of the
undersigned and inure to the benefit of the Payee and its successors, endorsees
and assigns. If any term or provision of this Note shall be held invalid,
illegal or unenforceable, the validity of all other terms and provisions hereof
shall in no way be affected thereby.

     EACH OF THE UNDERSIGNED AND, BY ITS ACCEPTANCE HEREOF, THE PAYEE HEREBY
KNOWINGLY, VOLUNTARILY AND INTENTIONALLY WAIVES (TO THE FULLEST EXTENT PERMITTED
BY APPLICABLE LAW) ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY OF ANY DISPUTE
ARISING UNDER OR RELATING TO THIS NOTE AND AGREES THAT ANY SUCH DISPUTE SHALL BE
TRIED BEFORE A JUDGE SITTING WITHOUT A JURY.

     THIS NOTE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF
THE STATE OF ILLINOIS WITHOUT GIVING EFFECT TO PRINCIPLES OF CONFLICTS OF LAW.

                                              GENAISSANCE
                                              PHARMACEUTICALS, INC.

                                              By: /s/ Kevin Rakin
                                                  -----------------------------

                                              Name:   Kevin Rakin
                                                    ---------------------------

                                              Title:  CFO & EVP
                                                     --------------------------

                                        3

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