Document:

Stock Purchase Agreement

 Exhibit 10.51 
 ***Text Omitted and Filed Separately 
 with the Securities and Exchange Commission. 

Confidential Treatment Requested 
 Under 17 C.F.R. Sections 200.80(b)(4) 
 and 240.24b-2. 
 STOCK PURCHASE AGREEMENT 
 THIS STOCK
PURCHASE AGREEMENT (this “Agreement”) is made as of May 25, 2006 (the “Effective Date”), by and between VICAL
INCORPORATED, a Delaware corporation (the “Company”), having its principal place of business at 10390 Pacific Center Court, San Diego, California 92121, USA, and AnGes MG Inc., a Japanese
corporation (the “Purchaser”), having its principal place of business at 7-7-15 Saito-Asagi, Ibaraki, Osaka, 567-0085, Japan. 
 WHEREAS, the Company and the Purchaser have entered into that certain Research and Development Agreement of even date herewith (the “R&D Agreement”); and 

WHEREAS, in connection with the R&D Agreement, the Company wishes to sell to the Purchaser, and Purchaser wishes to purchase
from the Company, shares of the Company’s common stock, par value $0.01 per share (“Common Stock”), on the terms and subject to the conditions set forth in this Agreement. 
 AGREEMENT 
 In
consideration of the mutual covenants contained in this Agreement, and for other good and valuable consideration, the receipt of which is hereby acknowledged, the Company and the Purchaser hereby agree as follows: 
  

	1.	DEFINITIONS 

 Capitalized terms used but not defined herein shall have the meanings provided in the R&D Agreement. In addition, the following terms shall have the respective meanings set forth below: 
 1.1 “Acquisition Transaction” shall have the meaning set forth in Section 10.2(g). 
 1.2 “Adjusted Share Amount” shall have the meaning set forth in Section 2.2(b). 
 1.3 “Affiliate” shall mean any entity controlled by, controlling, or under common control with a party hereto and shall
include any entity more than 50% of the voting stock or participating profit interest of which is owned or controlled, directly or indirectly, by a party, and any entity which owns or controls, directly or indirectly, more than 50% of the voting
stock of a party. 
 1.4 “Closing” shall refer to either the Initial Closing or the Milestone Closing, as
applicable. 

 1.5 “Closing Date” shall refer to either the Initial Closing Date or the
Milestone Closing Date, as applicable. 
 1.6 “Company Securities” shall have the meaning set forth in
Section 10.1. 
 1.7 “Excess Amount” shall have the meaning set forth in Section 2.2(b). 

1.8 “Exchange Act” shall mean the Securities Exchange Act of 1934, as amended, and the rules and regulations
promulgated thereunder. 
 1.9 “HSR Act” shall mean the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended.

 1.10 “Indemnitee” shall have the meaning set forth in Section 8.4(c). 
 1.11 “Indemnitor” shall have the meaning set forth in Section 8.4(c). 
 1.12 “Initial Closing” shall mean the closing of the sale and purchase of the Initial Shares. 
 1.13 “Initial Closing Date” shall mean the Effective Date or such other date or time as the Company and the Purchaser may
mutually agree. 
 1.14 “Initial Shares” shall mean the number of shares of Common Stock (rounded down to the
nearest whole number) equal to the quotient of $6,900,000 divided by the Initial Share Price. 
 1.15 “Initial Share
Price” shall mean the lesser of the volume weighted average trading price per share of Common Stock for the 30 trading days ending on the second trading day immediately preceding the Initial Closing Date as reported on the Nasdaq
National Market or $6.50 per share of Common Stock. 
 1.16 “Milestone Closing” shall mean the closing of the
sale and purchase of the Milestone Shares. 
 1.17 “Milestone Closing Date” shall mean the later of
(a) [***] and (b) [***] or such other date or time as the Company and the Purchaser may agree in writing. 
  

					
		 	2.	 	*** Confidential Treatment Requested

 1.18 “Milestone Share Cap” shall mean the number of whole shares of Common
Stock equal to 19.99% of the number of shares of Common Stock outstanding as of the Milestone Closing Date after giving effect to the Shares to be purchased under Section 2.2(b). 
 1.19 “Milestone Share Price” shall mean the volume weighted average trading price per share of Common Stock for the 30
trading days ending on the second trading day immediately preceding the Milestone Closing Date as reported on the Nasdaq National Market or such other national securities exchange or market on which the shares of Common Stock are then traded or
quoted; provided that, if shares of Common Stock are not traded on any recognized exchange or market, the Milestone Share Price shall be the fair market value of one share of Common Stock as determined in good faith by the Company’s Board of
Directors, which good faith determination shall include a discount for illiquidity from the value that would otherwise be determined if the shares of Common Stock were listed on a recognized exchange or market. 
 1.20 “Milestone Shares” shall mean the number of shares of Common Stock (rounded down to the nearest whole number) equal
to the quotient of $3,950,000 divided by the Milestone Share Price, as may be adjusted pursuant to Section 2.2(b). 
 1.21
“Person” shall mean any natural person, corporation, limited liability company, general or limited partnership, limited liability partnership, joint venture, joint stock company, trust, unincorporated organization,
association, sole proprietorship, governmental body, or agency or political subdivision of any government. 
 1.22
“Registrable Shares” shall mean the Shares; provided, however, that Shares shall only be treated as Registrable Securities if and only for so long as they (a) have not been disposed of pursuant to a registration
statement declared effective by the SEC, (b) have not been sold in a transaction exempt from the registration and prospectus delivery requirements of the Securities Act so that all transfer restrictions and restrictive legends with respect
thereto are removed upon the consummation of such sale and (c) are held by the Purchaser, an Affiliate of the Purchaser or any other person or entity to whom the rights under Article 6 have been transferred in accordance with Section 8.9.

 1.23 “Registration Expenses” shall mean all expenses incurred by the Company in complying with
Sections 8.1 and 8.2 hereof, including, without limitation, all registration, qualification and filing fees, printing expenses, escrow fees, fees and disbursements of counsel to the Company, blue sky fees and expenses, the expense of any
special audits incident to or required by any such registration and the fees and disbursements of counsel to the Purchaser (up to a maximum of $25,000 for such fees and disbursements), but excluding all underwriting discounts and selling commissions
in an applicable sale of Registrable Shares. 
 1.24 “Registration Statement” shall mean a registration
statement filed by the Company with the SEC to register Registrable Shares on Form S-3 under the Securities Act or on 

  

 3. 

 
such other form which is appropriate to register such Registrable Shares for resale from time to time by the Purchaser. 
 1.25 “Restricted Transaction” shall have the meaning set forth in Section 10.1. 
 1.26 “SEC” shall mean the United States Securities and Exchange Commission. 
 1.27 “SEC Filings” shall mean all reports, schedules, forms, statements and other documents filed or required to be filed
by the Company with the SEC pursuant to the requirements of the Securities Act or the Exchange Act, including material filed pursuant to Section 13(a) or 15(c) of the Exchange Act, in each case, together with all exhibits, supplements,
amendments and schedules thereto, and all documents incorporated by reference therein. 
 1.28 “Securities
Act” shall mean the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder. 
 1.29
“Shares” shall mean the shares of Common Stock being purchased under this Agreement. 
 1.30
“Suspension Period” shall have the meaning set forth in Section 8.2(b). 
  

	2.	AGREEMENT TO SELL AND PURCHASE. 

 2.1 Authorization of Shares. The Company has authorized the sale and issuance to the Purchaser of the Shares under the terms and
conditions of this Agreement. 
 2.2 Sale and Purchase. Subject to the terms and conditions hereof: 
 (a) Initial Shares. At the Initial Closing, the Company hereby agrees to issue and sell to the Purchaser, and the Purchaser
agrees to purchase from the Company, the Initial Shares at a price per share equal to the Initial Share Price. 
 (b)
Milestone Shares. At the Milestone Closing, the Company hereby agrees to issue and sell to the Purchaser, and the Purchaser agrees to purchase from the Company, the Milestone Shares at a price per share equal to the Milestone Share Price;
provided, however, that if (i) the sum of the Milestone Shares plus the Initial Shares would exceed the Milestone Share Cap or (ii) the Company is required to, but has not, obtained any stockholder approval required to comply
with Nasdaq rules or a similar rule for any portion of the Milestone Shares to be sold on the Milestone Closing Date, then the number of Shares to be purchased under this Section 2.2(b) shall be adjusted (the “Adjusted Share
Amount”). In the case that Section 2.2(b)(i) applies, the Adjusted Share Amount shall be the number of Shares that, when added to the Initial Shares, equals the Milestone Share Cap. In the case that Section 2.2(b)(ii) applies,
the Adjusted Share Amount shall be the number of Shares that the Company may sell to the Purchaser without being required to obtain such stockholder approval. If the Purchaser is required to purchase an Adjusted Share Amount pursuant to this
Section 2.2(b), then the 

  

 4. 

 
Purchaser’s obligation to purchase that portion (the “Excess Portion”) of the Milestone Shares in excess of the Adjusted Share
Amount shall be suspended for six months to allow the Company, if the Company so desires, to seek and obtain any required stockholder approval. If the Company has not obtained such stockholder approval within six months after the Milestone Closing
Date, then upon the expiration of such six months, the Purchaser shall be permanently relieved of any obligation to purchase the Excess Portion. In no event will the Company be required to sell or issue any portion of the Milestone Shares on the
Milestone Closing Date for which stockholder approval is required in order to comply with Nasdaq Stock Market Marketplace Rules (or similar stockholder voting requirements that may be imposed on the Company by any other established stock exchange or
national market system on which shares of Common Stock are traded or listed), unless and until the Company has obtained such stockholder approval. 
  

	3.	CLOSING, DELIVERY AND PAYMENT. 

 3.1 Initial Closing. The Initial Closing shall take place on the Initial Closing Date at the offices of Cooley Godward LLP,
4401 Eastgate Mall, San Diego, CA, 92121 or at such other place as the Company and the Purchaser may agree in writing. 
 3.2
Milestone Closing. Provided that a Final Stoppage Event has not occurred prior to the Milestone Closing Date, the Milestone Closing shall take place on the Milestone Closing Date at the offices of Cooley Godward LLP, 4401
Eastgate Mall, San Diego, CA, 92121 or at such other place as the Company and the Purchaser may agree in writing. For purposes of clarification, the Company’s obligation to offer and sell, and the Purchaser’s obligation to purchase, the
Milestone Shares shall terminate if a Final Stoppage Event occurs prior to the Milestone Closing Date or if the R&D Agreement is terminated in accordance with its terms prior to the Milestone Closing Date. Notwithstanding the foregoing, if
United States securities laws or SEC regulations so require, Vical shall be entitled to delay the Milestone Closing for up to six (6) months. 
 3.3 Delivery. At each Closing, subject to the terms and conditions hereof, the Company shall deliver to the Purchaser a certificate or certificates registered in the name of the Purchaser, and/or in such nominee name(s) as
designated in writing by the Purchaser, representing the number of Shares to be purchased at such Closing by the Purchaser, against payment of the purchase price therefor by wire transfer made payable to the order of the Company. 
  

	4.	REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE COMPANY.

 The Company hereby represents and warrants to the Purchaser as of the Effective Date as follows: 
 4.1 Representations in the R&D Agreement. The provisions of Sections 9.2 and 9.4 of the R&D Agreement are hereby incorporated
by reference into this Agreement. 
  

 5. 

 4.2 Organization, Good Standing and Qualification. The Company is a corporation duly
organized, validly existing and in good standing under the laws of the State of Delaware and has all requisite corporate power and authority to carry on its business. The Company is duly qualified to transact business as a corporation and is in good
standing in each jurisdiction in which the failure so to qualify would have a material adverse effect upon the Company’s ability to perform its obligations under this Agreement. 
 4.3 Authorization; Due Execution. The Company has the requisite corporate power and authority to enter into this Agreement and to perform
its obligations under the terms of this Agreement. All corporate action on the part of the Company, its officers, directors and stockholders necessary for the authorization, execution and delivery of this Agreement has been taken. This Agreement has
been duly authorized, executed and delivered by the Company and, upon due execution and delivery by the Purchaser of this Agreement, this Agreement will be a valid and binding obligation of the Company, enforceable in accordance with its terms,
except (a) as enforceability may be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors’ rights generally or by equitable principles or (b) to the extent that the enforceability of the
indemnification provisions set forth in Section 8.4 hereof may be limited by applicable laws. 
 4.4 Valid Issuance of
Stock. The Shares, when issued, sold and delivered in accordance with the terms of Sections 2 and 3 hereof for the consideration and on the terms and conditions set forth herein, will be duly and validly authorized and issued, fully paid and
nonassessable and, based in part upon the representations of the Purchaser in this Agreement, will be issued in compliance with all applicable federal and state securities laws. 
 4.5 No Defaults. There exists no default under the provisions of any instrument or agreement evidencing, governing or otherwise relating to
any material indebtedness of the Company, or with respect to any other agreement, a default under which could have a material adverse effect upon the Company’s ability to perform its obligations under this Agreement. 
 4.6 SEC Filings. The Company has timely filed with the SEC all SEC Filings. The SEC Filings were prepared in accordance with and, as of the
date on which each such SEC Filing was filed with the SEC, complied in all material respects with the applicable requirements of the Exchange Act. None of such SEC Filings, including, without limitation, any financial statements, exhibits and
schedules included therein and documents incorporated therein by reference, at the time filed, declared effective or mailed, as the case may be, contained an untrue statement of a material fact or omitted to state a material fact required to be
stated therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading. 
 4.7 Governmental Consents. No consent, approval, order or authorization of, or registration, qualification, designation, declaration or filing with, any federal, state, local or provincial governmental authority on the part of
the Company is required in connection with the consummation of the transactions contemplated by this Agreement, except for such approvals or 

  

 6. 

 
consents as may be required under the HSR Act and such other notices required or permitted to be filed with certain state and federal securities commissions
after the Effective Date, which notices will be filed on a timely basis. 
 4.8 No Conflict. The Company’s execution,
delivery and performance of this Agreement does not violate any provision of the Company’s Restated Certificate of Incorporation or Bylaws, each as amended as of the date hereof (copies of which have been filed with the Company’s SEC
Filings), any provision of any order, writ, judgment, injunction, decree, determination or award to which the Company is a party or by which it is bound, or, to the Company’s knowledge, any law, rule or regulation currently in effect having
applicability to the Company. 
  

	5.	REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE PURCHASER.

 The Purchaser hereby makes the following representations and warranties to the Company: 
 5.1 Organization and Good Standing. The Purchaser is a corporation duly organized, validly existing and in good standing under the laws of
its jurisdiction of incorporate and has all requisite corporate power and authority to carry on its business. 
 5.2 Authorization;
Due Execution. The Purchaser has the requisite corporate power and authority to enter into this Agreement and to perform its obligations under the terms of this Agreement. All corporate action on the part of the Purchaser, its officers, directors
and stockholders necessary for the authorization, execution and delivery of this Agreement have been taken. This Agreement has been duly authorized, executed and delivered by the Purchaser, and, upon due execution and delivery by the Company, this
Agreement will be a valid and binding obligation of the Purchaser, enforceable in accordance with its terms, except (a) as enforceability may be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws affecting
creditors’ rights generally or by equitable principles or (b) to the extent that the enforceability of the indemnification provisions set forth in Section 8.4 hereof may be limited by applicable laws. 
 5.3 No Current Ownership in the Company. Other than the Shares to be acquired, and the rights provided for, under this Agreement, the Purchaser
does not own any shares of Common Stock or any rights to acquire Common Stock. 
 5.4 Purchase Entirely for Own Account. This
Agreement is made with the Purchaser in reliance upon the Purchaser’s representation to the Company, which by the Purchaser’s execution of this Agreement it hereby confirms, that the Shares purchased by the Purchaser will be acquired for
investment for the Purchaser’s own account, not as a nominee or agent, and not with a view to the resale or distribution of any part thereof, and that the Purchaser has no present intention of selling, granting any participation in, or
otherwise distributing the same. By executing this Agreement, the Purchaser further represents that it does not have any 

  

 7. 

 
contract, undertaking, agreement or arrangement with any person to sell, transfer or grant participation to such person or to any third party, with respect
to the Shares, if issued. 
 5.5 Disclosure of Information. The Purchaser has received all the information that it has requested and
that it considers necessary or appropriate for deciding whether to enter into this Agreement and to acquire the Shares. The Purchaser further represents that it has had an opportunity to ask questions and receive answers from the Company regarding
the terms and conditions of the offering of the Shares. Section 5.5 is not intended to limit in any respect the representations and warranties made by Vical in Section 4.6. 
 5.6 Investment Experience. The Purchaser is an investor in securities of companies in the development stage and acknowledges that it is able to
fend for itself, can bear the economic risk of its investment and has such knowledge and experience in financial or business matters that it is capable of evaluating the merits and risks of the investment in the Shares. The Purchaser also represents
it has not been organized solely for the purpose of acquiring the Shares. 
 5.7 Accredited Investor. The Purchaser is an
“accredited investor” as such term is defined in Rule 501 of the General Rules and Regulations promulgated by the SEC pursuant to the Securities Act. 
 5.8 Restricted Securities. The Purchaser understands that: 
 (a) the Shares
will not be registered under the Securities Act by reason of a specific exemption therefrom, that such securities must be held by it indefinitely and that the Purchaser must, therefore, bear the economic risk of such investment indefinitely, unless
a subsequent disposition thereof is registered under the Securities Act or is exempt from such registration; 
 (b)
each certificate representing the Shares, if issued, will be endorsed with the following legends: 
 (i) THE SECURITIES
REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE “ACT”) AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR UNLESS
THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED; and 
 (ii) Any legend required to be placed thereon under applicable state securities laws. 
  

 8. 

 (c) The Company will instruct its transfer agent not to register the transfer of
the Shares (or any portion thereof) unless the conditions specified in the foregoing legends are satisfied, until such time as a transfer is made, pursuant to the terms of this Agreement, and in compliance with Rule 144 under the Securities Act
(“Rule 144”) or pursuant to a registration statement or, if the opinion of counsel referred to above is to the further effect that such legend is not required in order to establish compliance with any provisions of the
Securities Act or this Agreement. 
 5.9 No Short Sales. The Purchaser has not engaged, and will not engage, in any short sales
of the Company’s Common Stock within the [***] trading days prior to the date on which a Closing Date is scheduled under the R&D Agreement. 
 5.10 No Legal, Tax or Investment Advice. The Purchaser understands that nothing in the SEC Filings, this Agreement or any other materials presented to the Purchaser in connection with the purchase and
sale of the Shares constitutes legal, tax or investment advice and that independent legal counsel has reviewed these documents and materials on the Purchaser’s behalf. The Purchaser has consulted such legal, tax and investment advisors as it,
in its sole discretion, has deemed necessary or appropriate in connection with its purchase of the Shares. 
  

	6.	CONDITIONS TO THE COMPANY’S OBLIGATIONS AT CLOSING.

 6.1 Initial Closing. The Company’s obligation to sell, issue and deliver the Initial Shares to the
Purchaser at the Initial Closing shall be subject to the following conditions to the extent not waived by the Company: 
 (a) Receipt of Payment. The Company shall have received payment in full, by wire transfer of immediately available funds, for the Initial Shares at the Initial Share Price. 
 (b) R&D Agreement. The R&D Agreement shall have been executed and delivered by the Purchaser. 
 (c) Representations and Warranties; Obligations. The representations and warranties made by the Purchaser in Section 5
hereof shall be true and correct on the Initial Closing Date. The Purchaser shall have performed and complied with all obligations and conditions required to be performed and complied with by the Purchaser under this Agreement on or prior to the
Initial Closing Date. 
  

					
		 	9.	 	*** Confidential Treatment Requested

 (d) HSR Act. Any waiting period applicable to the consummation of the
issuance and sale of the Shares to the Purchaser on the Initial Closing Date or to the R&D Agreement under the HSR Act shall have expired or been terminated. 
 6.2 Milestone Closing. The Company’s obligation to sell, issue and deliver the Milestone Shares to the Purchaser at the Milestone Closing shall be subject to the following conditions to the extent
not waived by the Company: 
 (a) Receipt of Payment. The Company shall have received payment in full, by
wire transfer of immediately available funds, for the Milestone Shares at the Milestone Share Price. 
 (b) R&D
Agreement. The R&D Agreement shall be in full force and effect as of the Milestone Closing Date. 
 (c) HSR
Act. Any waiting period applicable to the consummation of the issuance and sale of the Shares to the Purchaser on the Milestone Closing Date or to the R&D Agreement under the HSR Act shall have expired or been terminated. 
 (d) Required Stockholder Approval. Solely with respect to the sale of any portion of the Shares issuable on the Milestone
Closing Date for which stockholder approval is required in order to comply with Nasdaq Stock Market Marketplace Rules (or similar stockholder voting requirements that may be imposed on the Company by any other established stock exchange or national
market system on which shares of Common Stock are traded or listed), the Company shall have obtained such stockholder approval. 
  

	7.	CONDITIONS TO THE PURCHASERS’ OBLIGATIONS AT CLOSING.

 7.1 Initial Closing. The Purchaser’s obligation to accept delivery of and pay for the Initial Shares
at the Initial Closing shall be subject to the following conditions to the extent not waived by the Purchaser: 
 (a)
Representations and Warranties; Obligations. The representations and warranties made by the Company in Section 4 hereof shall be true and correct on the Initial Closing Date. The Company shall have performed and complied with all
obligations and conditions to be performed and complied with by the Company under this Agreement on or prior to the Initial Closing Date. 
 (b) R&D Agreement. The R&D Agreement shall have been executed and delivered by the Company and the Purchaser. 
  

 10. 

 (c) HSR Act. Any waiting period applicable to the consummation of the
issuance and sale of the Shares to the Purchaser on the Initial Closing Date or to the R&D Agreement under the HSR Act shall have expired or been terminated. 
 7.2 Milestone Closing. The Purchaser’s obligation to accept delivery of and pay for the Milestone Shares at the Milestone Closing shall be subject to the following conditions to the extent not
waived by the Purchaser: 
 (a) Representations and Warranties; Obligations. The representations and warranties
made by the Company in Section 4 hereof shall be true and correct in all material respects on the Milestone Closing Date as if made on such date; provided, however, that the Company shall deliver to the Purchaser an officer’s
certificate updating as of a reasonably recent date prior to the Milestone Closing Date the representations and warranties made by the Company in Section 4 hereof, which shall be true and correct in all material respects on and as of the
Milestone Closing Date. The Company shall have performed and complied with all obligations and conditions to be performed and complied with by the Company under this Agreement and the R&D Agreement on or prior to the Milestone Closing Date.

 (b) R&D Agreement. The R&D Agreement shall be in full force and effect as of the Milestone Closing
Date. 
 (c) HSR Act. Any waiting period applicable to the consummation of the issuance and sale of the Shares
to the Purchaser on the Milestone Closing Date or to the R&D Agreement under the HSR Act shall have expired or been terminated. 
  

	8.	REGISTRATION RIGHTS. 

 8.1 Registration of Shares. 
 (a) At any time that the Purchaser is entitled to sell or transfer any
Shares pursuant to Section 9 hereof, the Purchaser may request, in writing, that the Company effect the registration for resale of Registrable Shares pursuant to a Registration Statement. Thereupon, the Company shall, as expeditiously as
possible, use its best efforts to effect the registration for resale of all such Registrable Shares. If the Purchaser intends to distribute the Registrable Shares by means of an underwriting, it shall so advise the Company in its request.

 (b) The Company shall not be required to effect more than one registration pursuant to this Section 8.1. If the
Company has filed a registration statement within six months of the proposed date of filing of the applicable Registration Statement, the Company shall not be obligated to file a Registration Statement until after the end of such six month period.

 (c) If at the time of any request to register Registrable Shares pursuant to this Section 8.1, the Company is
engaged in any activity which, in the good faith determination of the Company’s Board of Directors, would be adversely affected by the requested registration to the material detriment of the Company, then the Company may at its option direct
that such request 

  

 11. 

 
be delayed for a period not in excess of three months from the effective date of such offering or the date of commencement of such other material activity,
as the case may be, such right to delay a given request may not be exercised by the Company more than once in any one-year period. 
 8.2 Registration Procedures. If and whenever the Company is required by the provisions of this Agreement to use its best efforts to effect the registration of any of the Registrable Shares under the Securities Act, the Company
shall do the following: 
 (a) The Company shall file with the SEC a Registration Statement with respect to such
Registrable Shares within 30 days after receiving such request and use its best efforts to cause that Registration Statement to become effective as soon as is reasonably possible. 
 (b) The Company shall as expeditiously as possible prepare and file with the SEC any amendments and supplements to the Registration
Statement and the prospectus included in the Registration Statement and such SEC Filings and other filings required by the SEC, in each case, as may be necessary to keep the Registration Statement effective, in the case of a firm commitment
underwritten public offering, until each underwriter has completed the distribution of all securities purchased by it and, in the case of any other offering, until the earlier of the sale of all Registrable Shares covered thereby or such time as all
of the Registrable Shares held by the Purchaser that are registered under such Registration Statement can be sold pursuant to Rule 144(k) or within a given three-month period pursuant to Rule 144. Notwithstanding the foregoing, if, at any time
following the effectiveness of a Registration Statement, the Company shall have determined that the Company may be required to disclose any material corporate development, the Company may suspend the effectiveness of a Registration Statement until
such time as an amendment to such Registration Statement has been filed by the Company and declared effective by the SEC or until such time as the Company has filed an appropriate report with the SEC pursuant to the Exchange Act, by giving notice to
the Purchaser. The Company will use its best efforts to limit the length of any period of suspension of a Registration Statements to a reasonable period of time (which shall in no event be longer than 90 days or such longer period of time as is
required, due to circumstances outside of the Company’s control, such as a delay by the SEC) (a “Suspension Period”), and further, the Company will use its best efforts to amend or supplement such prospectus in order to
cause such prospectus not to include any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing
and end the Suspension Period. The Purchaser agrees that, upon receipt of any notice from the Company of a Suspension Period, the Purchaser will not sell any Registrable Shares pursuant to the Registration Statement during the Suspension Period
until (i) the Purchaser is advised in writing by the Company that the use of the applicable prospectus may be resumed, (ii) the Purchaser has received copies of any additional or supplemental or amended prospectus, if applicable, and
(iii) the Purchaser has received copies of any additional or supplemental filings which are incorporated or deemed to be incorporated by reference in such prospectus. 
  

 12. 

 (c) The Company shall furnish to the Purchaser such reasonable numbers of copies
of the prospectus and the Registration Statement, including a preliminary prospectus, in conformity with the requirements of the Securities Act, and such other documents as the Purchaser may reasonably request in order to facilitate the public sale
or other disposition of its Registrable Shares. If the Company has delivered preliminary or final prospectuses to the Purchaser and after having done so the prospectus is amended to comply with the requirements of the Securities Act, the Company
shall promptly notify the Purchaser and, if requested, the Purchaser shall immediately cease making offers of Registrable Shares and return all prospectuses to the Company. The Company shall promptly provide the Purchaser with revised prospectuses
and, following receipt of the revised prospectuses, the Purchaser shall be free to resume making offers of its Registrable Shares. 
 (d) The Purchaser hereby covenants with the Company, in connection with any sale of the Registrable Securities, the Purchaser shall cause the prospectus delivery requirements under the Securities Act to be satisfied and shall
otherwise comply with all applicable laws, rules and regulations. The Purchaser acknowledges and agrees that the Registrable Securities sold pursuant to the Registration Statement are not transferable on the books of the Company unless the stock
certificate submitted to the transfer agent evidencing such Registrable Securities is accompanied by a certificate reasonably satisfactory to the Company to the effect that (i) the Registrable Securities have been sold in accordance with such
Registration Statement and (ii) the requirement of delivering a current prospectus has been satisfied. 
 (e) The
Company shall use its best efforts to register or qualify the Registrable Shares covered by the Registration Statement under the securities or blue sky laws of such states as the Purchaser shall reasonably request, and do any and all other acts and
things that may be necessary or desirable to enable the Purchaser to consummate the public sale or other disposition in such states of its Registrable Shares; provided, however, that the Company shall not be required in connection with this
Section 8.2(d) to qualify as a foreign corporation or execute a general consent to service of process in any jurisdiction. 
 8.3
Allocation of Expenses. The Company will pay all Registration Expenses of any registration under this Agreement. The Purchaser will pay all other expenses incurred in connection with any registration hereunder. 
 8.4 Indemnification and Contribution. 
 (a) In the event of any registration of any of the Registrable Shares under the Securities Act pursuant to this Agreement, the Company will indemnify and hold harmless the seller of such Registrable Shares,
each underwriter of such Registrable Shares, and each other Person, if any, who controls such seller or underwriter within the meaning of the Securities Act or the Exchange Act against any losses, claims, damages or liabilities, joint or several, to
which such seller, underwriter or controlling Person may become subject under the Securities Act, the Exchange Act, state securities or blue sky laws or otherwise, insofar as such losses, claims, 

  

 13. 

 
damages or liabilities (or actions in respect thereof) arise out of or are based upon any untrue statement or alleged untrue statement of any material fact
contained in any Registration Statement under which such Registrable Shares were registered under the Securities Act, any preliminary prospectus or final prospectus contained in the Registration Statement, or any amendment or supplement to such
Registration Statement or arise out of or are based upon the omission or alleged omission to state a material fact required to be stated therein or necessary to make the statements therein not misleading; and the Company will reimburse such seller,
underwriter and each such controlling Person for any legal or any other expenses reasonably incurred by such seller, underwriter or controlling Person in connection with investigating or defending any such loss, claim, damage, liability or action;
provided, however, that the Company will not be liable in any such case to the extent that any such loss, claim, damage or liability arises out of or is based upon any untrue statement or omission made in such Registration Statement,
preliminary prospectus or final prospectus, or any such amendment or supplement, in reliance upon and in conformity with information furnished to the Company, in writing, by or on behalf of such seller, underwriter or controlling Person specifically
for use in the preparation thereof. 
 (b) In the event of any registration of any of the Registrable Shares under the
Securities Act pursuant to this Agreement, each seller of Registrable Shares, severally and not jointly, will indemnify and hold harmless the Company, each of its directors and officers and each underwriter (if any) and each Person, if any, who
controls the Company or any such underwriter within the meaning of the Securities Act or the Exchange Act, against any losses, claims, damages or liabilities, joint or several, to which the Company, such directors and officers, underwriter or
controlling Person may become subject under the Securities Act, Exchange Act, state securities or blue sky laws or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon any
untrue statement or alleged untrue statement of a material fact contained in any Registration Statement under which such Registrable Shares were registered under the Securities Act, any preliminary prospectus or final prospectus contained in the
Registration Statement, or any amendment or supplement to the Registration Statement, or arise out of or are based upon any omission or alleged omission to state a material fact required to be stated therein or necessary to make the statements
therein not misleading, if the statement or omission was made in reliance upon and in conformity with information relating to such seller furnished in writing to the Company by or on behalf of such seller specifically for use in connection with the
preparation of such Registration Statement, prospectuses, amendment or supplement; provided, however, that the obligations of each seller of Registrable Securities hereunder shall be limited to an amount equal to the proceeds to such seller
of Registrable Shares sold in connection with such registration. 
 (c) Each party entitled to indemnification under
this Section 8.4 (the “Indemnified Party”) shall give notice to the party required to provide indemnification (the “Indemnifying Party”) promptly after such Indemnified Party has actual knowledge
of any claim as to which indemnity may be sought, and shall permit the Indemnifying Party to assume the defense of any such claim or any litigation resulting therefrom; provided that counsel for the Indemnifying Party, who shall conduct the
defense of such claim or litigation, shall be approved 

  

 14. 

 
by the Indemnified Party (whose approval shall not be unreasonably withheld); and, provided further that the failure of any Indemnified Party to give
notice as provided herein shall not relieve the Indemnifying Party of its obligations under this Section 8.4. The Indemnified Party may participate in such defense at such party’s expense; provided, however, that the Indemnifying
Party shall pay such expense if representation of such Indemnified Party by the counsel retained by the Indemnifying Party would be inappropriate due to actual or potential differing interests between the Indemnified Party and any other party
represented by such counsel in such proceeding. No Indemnifying Party, in the defense of any such claim or litigation shall, except with the consent of each Indemnified Party, consent to entry of any judgment or enter into any settlement which does
not include as an unconditional term thereof the giving by the claimant or plaintiff to each Indemnified Party of a release from all liability in respect of such claim or litigation, and no Indemnified Party shall consent to entry of any judgment or
settle such claim or litigation without the prior written consent of each other Indemnified Party. 
 (d) In order to
provide for just and equitable contribution to joint liability under the Securities Act in any case in which either (i) the Purchaser makes a claim for indemnification pursuant to this Section 8.4 but it is judicially determined (by the
entry of a final judgment or decree by a court of competent jurisdiction and the expiration of time to appeal or the denial of the last right of appeal) that such indemnification may not be enforced in such case notwithstanding the fact that this
Section 8.4 provides for indemnification in such case, or (ii) contribution under the Securities Act may be required on the part of the Purchaser in circumstances for which indemnification is provided under this Section 8.4; then each
Indemnifying Party shall contribute to the amount paid or payable by such Indemnified Party as a result of such losses, claims, liabilities, or expenses (or actions in respect thereof) in such proportion as is appropriate to reflect the relative
fault of the Indemnifying Party and the Indemnified Party as well as any other relevant equitable considerations. The relative fault of such Indemnifying Party and Indemnified Party shall be determined by reference to, among other things, whether
the untrue or alleged untrue statement of a material fact or omission or alleged omission to state a material fact relates to information supplied by such Indemnifying Party or Indemnified Party, and the parties’ relative knowledge, access to
information and opportunity to correct or prevent such statement or omission. The parties hereto agree that it would not be just and equitable if contribution pursuant to this Section 8.4(d) were determined by pro rata allocation or by any
other method of allocation which does not take account of the equitable considerations referred to in this Section 8.4(d). The amount paid or payable by an Indemnified Party as a result of the losses, claims, damages, liabilities, or expenses
(or actions in respect thereof) referred to above shall be deemed to include any legal or other fees or expenses reasonably incurred by such Indemnified Party in connection with investigating or, except as provided in Section 8.4(c), defending
any such action or claim. Notwithstanding the provisions of this Section 8.4(d), (A) the Purchaser will not be required to contribute any amount in excess of the proceeds to it of all Registrable Shares sold by it pursuant to such
Registration Statement, and (B) no Person guilty of fraudulent misrepresentation, within the meaning of Section 11(f) of the Securities Act, shall be entitled to contribution from any Person who is not guilty of such fraudulent
misrepresentation. 
  

 15. 

 8.5 Information from the Purchaser. If the Purchaser requests a registration pursuant to
Section 8.1, it shall furnish to the Company such information regarding the Purchaser and the distribution proposed by the Purchaser as the Company may reasonably request in writing and as shall be required in connection with any registration,
qualification or compliance referred to in this Agreement. 
 8.6 Rule 144 Requirements. The Company agrees to: 
 (a) make and keep public information available in compliance with the requirements of Rule 144; 
 (b) use its best efforts to file with the SEC in a timely manner all reports and other documents required of the Company under the
Securities Act and the Exchange Act; and 
 (c) furnish to the Purchaser upon request (i) a written statement by
the Company as to its compliance with the reporting requirements of said Rule 144, and the reporting requirements of the Securities Act and the Exchange Act, (ii) a copy of the most recent annual or quarterly report of the Company, and
(iii) such other reports and documents of the Company as the Purchaser may reasonably request to avail itself of any similar rule or regulation of the SEC allowing it to sell the Shares without registration. 
 8.7 Market Stand-Off. If requested by the representative of the underwriters of Common Stock (or other securities) of the Company, the
Purchaser shall not sell or otherwise transfer or dispose of any Common Stock (or other securities) of the Company held by the Purchaser for a period specified by the representative of the underwriters, in any case not to exceed 90 days following
any registered offering of the Common Stock of the Company. The obligations described in this Section 8.7 shall not apply to a registration effected pursuant to a Registration Statement. The Company may impose stop-transfer instructions with
respect to the shares of Common Stock (or other securities) subject to the foregoing restriction until the end of said periods. 
 8.8
Termination of Registration Rights. All of the Company’s obligations to register Registrable Shares, and the Purchaser’s rights to cause such registration, under this Agreement shall cease and terminate upon the earlier of
(a) such time as all of the Registrable Shares have been sold by the Purchaser in one or more transactions in which the Purchaser’s registration rights under this Section 8 have not been transferred under Section 8.9 or
(b) such time as all of the Registrable Shares may be sold by the Purchaser pursuant to Rule 144(k) or in a three-month period pursuant to Rule 144. 
 8.9 Transfer of Registration Rights. Subject to Section 9, the rights granted to the Purchaser by the Company under this Section 8 may be assigned in full by the Purchaser to a 
  

 16. 

 
third party in connection with a sale by the Purchaser of Registrable Shares to such third party, provided, however, that (a) such transfer may
otherwise be effected in accordance with applicable securities laws; (b) the Purchaser gives prior written notice to the Company at least 10 days prior to the date of filing of the Registration Statement under Section 8.2(a); and
(iii) such transferee agrees to comply with the terms and provisions of this Agreement, and such transfer is otherwise in compliance with this Agreement. Except as specifically permitted by this Section 8.9, the rights of a holder of
Registrable Shares shall not be transferable to any other person or entity, and any attempted transfer shall cause all rights of such holder therein to be forfeited 
  

	9.	RESTRICTIONS ON TRANSFER. 

 9.1 Restrictions. The Purchaser agrees not to make any disposition of all or any portion of the Shares unless and until the earliest to occur of the following events: 
 (a) Final adjudication of the results of the Phase 3 Clinical Trial; 
 (b) At such time as the Purchaser’s cash and cash equivalents are below [***], as certified to the Company in writing by an
officer of the Purchaser; 
 (c) The R&D Agreement has been validly terminated. 
 For the avoidance of doubt, after the occurrence of any of the events set forth in Section 9(a) through (c), AnGes shall have the right hereunder to
sell all or any portion of the Shares. 
 9.2 Early Termination of Restrictions. Notwithstanding Section 9.1, in the event
that, at any time after the second anniversary of the Initial Closing Date and on or prior to the date of the earliest to occur of the events set forth in Sections 9.1(a), (b) or (c), the Company enters into a strategic alliance with a
third party for a program or product of the Company that is comparable to the transactions contemplated by this Agreement and the R&D Agreement, including, without limitation, as a term of such alliance, the purchase of equity securities of the
Company in order to fund research and development activities under such alliance (a “New Alliance”), and if the terms of such New Alliance provide for a period during which there are restriction on transfer of such equity
securities of the Company issued to such third party that is less than the anticipated total duration of the period over which research and development funding is to be provided to the Company as part of such alliance (with the understanding that
Section 9.1 contemplates that the duration of the restrictions on transfer of all or any portion of the Shares is intended to be equivalent to the period over which the Purchaser is providing funding for the Phase 3 Clinical Trial, which
is anticipated to be three years), then this Section 9.2 shall apply. Where the conditions of this Section 9.2 apply, the duration of the restriction on transfer of the Shares under this Section 9 shall be reduced, if applicable, to
that 

  

					
		 	17.	 	*** Confidential Treatment Requested

 
period of time equal to (a) three years multiplied by (b) a fraction equal to (i) the period during which there are restrictions on transfer
of equity securities of the Company issued to the third party in the New Alliance, divided by (ii) the anticipated total duration of the period over which such third party is providing research and development funding to the Company in the New
Alliance. For example, if the New Alliance provides that the period during which there are restrictions on transfer of equity securities of the Company issued to the third party in the New Alliance is two years, and the anticipated total duration of
the period over which such third party is providing research and development funding to the Company in the New Alliance is four years, then the duration of the restriction on transfer of the Shares under this Section 9 shall be reduced to one
year and six months (i.e. (a) three years, multiplied by (b) the fraction equal to (i) two divided by (ii) four). Any disposition of the Shares permitted under this Section 9 shall remain subject to the provisions of
applicable securities laws, rules and regulations. 
  

	10.	ADDITIONAL COVENANTS.  

 10.1 Restricted Transactions. For the term of the R&D Agreement, and except as permitted by Section 9 with respect to the Shares, the Purchaser shall not, and shall not authorize, instruct, facilitate or permit any of
its Affiliates or any other person or entity, to engage in any of the following (a “Restricted Transaction”): (a) offer, sell or contract to sell securities of the Company or any of its affiliates or successors or any
instruments convertible into or exchangeable or exercisable for securities of the Company or any of its Affiliates or successors (the “Company Securities”) in a private placement or similar transaction, (b) sell any
option or contract to purchase, purchase any option or contract to sell or grant any option, right or warrant for the sale of the Company Securities, or (c) enter into any swap or any other agreement or any transaction that transfers, in whole
or in part directly or indirectly, the economic consequence of ownership of the Company Securities, whether any such swap or transaction is to be settled by delivery of Common Stock or other securities, in cash or otherwise. 
 10.2 Standstill. The Purchaser agrees that for the term of the R&D Agreement, except with the prior written consent of the Company, the
Purchaser shall not, and shall not permit any of its officers, directors or affiliates to: 
 (a) acquire, offer to
acquire, agree to acquire or cause or effect the acquisition of, directly or indirectly, by purchase or otherwise, beneficial ownership of any securities or instruments convertible into any of the Company Securities such that the aggregate
beneficial ownership of the Purchaser, its officers, directors and Affiliates (on a combined basis, and if prior to the Milestone Closing Date, including for purposes of calculating such beneficial ownership, the Milestone Shares) is 20% or more of
the Company’s outstanding Common Stock. 
 (b) solicit or encourage any other entity to solicit proxies (as such
terms are defined in Regulation 14A under the Exchange Act) with respect to any matter involving the Company or otherwise initiate, propose or solicit, or induce any other person or entity to initiate, propose or solicit any stockholder of the
Company, any stockholder proposal, any tender offer 

  

 18. 

 
for Company Securities, any change of control of the Company, or for the purpose of convening a stockholders’ meeting of the Company; 
 (c) deposit any Company Securities in any voting trust or subject them to any voting agreement or other agreement of similar
effect; 
 (d) join or form any partnership, limited partnership, syndicate, or other group within the meaning of
Section 13(d)(3) of the Exchange Act for the purpose of acquiring, holding or disposing of beneficial ownership of any Company Securities or encourage, advise or, for the purpose of circumventing or avoiding any of the provisions of this
Agreement, assist any person or entity to do any of the foregoing or otherwise take any action individually or jointly with any partnership, limited partnership, syndicate, or other group or assist any other person, corporation, entity or group in
taking any action it could not individually take under this Agreement; 
 (e) make, effect, cause, initiate or
participate in any Acquisition Transaction (as defined below) with respect to the Company; or 
 (f) make any public
proposals to the Company or any of its Affiliates, directors, officers, employees, agents, representatives, successors or security holders concerning any Acquisition Transaction relating to the Company or any Affiliate or successor of the Company or
take any action that would require the Company to make a public announcement regarding the possibility of an Acquisition Transaction with the Purchaser or any of its Affiliates. 
 (g) For purposes of this Section 10.2, “Acquisition Transaction” shall mean any transaction involving:
(i) any sale, license, lease, exchange, transfer or other disposition of the assets of the Company or any subsidiary of the Company constituting more than 50% of the consolidated assets of the Company or accounting for more than 50% of the
consolidated revenues of the Company in any one transaction or in a series of related transactions; (ii) any offer to purchase, tender offer, exchange offer or any similar transaction or series of related transactions made by any person
involving more than 50% of the outstanding shares of capital stock of the Company; or (iii) any merger, consolidation, business combination, share exchange, reorganization or similar transaction or series of related transactions involving the
Company or any subsidiary of the Company whereby the holders of voting capital stock of the Company immediately prior to any such transaction hold less than 50% of the voting capital stock of the Company or the surviving corporation (or its parent
company) immediately after the consummation of any such transaction. 
 10.3 Termination of Standstill. The obligations of the
Purchaser under Section 10.2 shall terminate in the event of (a) any bona fide unsolicited third party tender or exchange offer for at least 50% of the outstanding voting capital stock of the Company, (b) the Company
enters into any agreement for an Acquisition Transaction with any entity not affiliated with the Purchaser pursuant to an unsolicited proposal by such third party, or (c) the Company, upon the decision of the Company’s Board of Directors,
initiates a structured auction process with regard 

  

 19. 

 
to an Acquisition Transaction, but excluding any market check in response to an unsolicited proposal made by any entity not affiliated with the Purchaser.
All of the provisions of Section 10.2 shall be reinstated and shall apply in full force according to their terms in the event that: (i) if the provisions of Section 10.2 shall have terminated as the result of a tender or exchange
offer, such tender or exchange offer (as originally made or as amended or modified) shall have terminated (without closing) prior to the commencement of a tender or exchange offer by the Purchaser that would have been permitted to be made pursuant
to the first sentence of this Section 10.3 as a result of such third-party tender or exchange offer; (ii) any tender or exchange offer by the Purchaser (as originally made or as extended or modified) that was permitted to be made pursuant
to this Section 10.3 shall have terminated (without closing); or (iii) if the provisions of Section 10.2 shall have terminated as a result of any action by the Company referred to in this Section 10.3, the Company shall have
determined not to take any of such actions (and no such transaction shall have closed) prior to the commencement of any action by the Purchaser that would have been permitted to be made pursuant to this Section 10.3 as a result of the initial
determination of the Company referred to in this Section 10.3. Upon reinstatement of the provisions of Section 10.2, the provisions of this Section 10.3 shall continue to govern in the event that any of the events described in this
Section 10.3 shall occur. 
  

	11.	MISCELLANEOUS. 

 11.1
Waivers and Amendments. Neither this Agreement nor any provision hereof may be changed, waived, discharged, terminated, modified or amended except upon the written consent of the Company and the Purchaser. 
 11.2 Severability. In case any provision contained in this Agreement should be invalid, illegal or unenforceable in any respect, the
validity, legality and enforceability of the remaining provisions contained herein shall not in any way be affected or impaired thereby. 
 11.3 Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the State of Delaware, without regard to conflicts of law principles. 
 11.4 Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original document, and all
of which, together with this writing, shall be deemed one instrument. 
 11.5 Successors and Assigns. Except as expressly
provided hereunder, neither this Agreement nor any rights or obligations hereunder may be assigned or otherwise transferred by either party without the prior written consent of the other party; provided, however, that either party may assign
this Agreement and its rights and obligations hereunder without the other party’s consent: 
 (a) in connection
with the transfer or sale of all or substantially all of the business of such party to which the R&D Agreement relates to a third party, whether by merger, sale of stock, sale of assets or otherwise; or 
  

 20. 

 (b) to an Affiliate, provided that the assigning party shall remain liable and
responsible to the non-assigning party hereto for the performance and observance of all such duties and obligations by such Affiliate. 
 The
rights and obligations of the parties under this Agreement shall be binding upon and inure to the benefit of the successors and permitted assigns of the parties. Any assignment not in accordance with this Agreement shall be void. 
 11.6 Entire Agreement. This Agreement and other documents (including the R&D Agreement) delivered pursuant hereto, including the
exhibits, constitute the full and entire understanding and agreement between the parties with regard to the subjects hereof and thereof. 
 11.7 Payment of Fees and Expenses. Each of the Company and the Purchaser shall bear its own expenses and legal fees incurred on its behalf with respect to this Agreement and the transactions contemplated hereby. If any action
at law or in equity is necessary to enforce or interpret the terms of this Agreement, the prevailing party shall be entitled to reasonable attorney’s fees, costs and necessary disbursements in addition to any other relief to which such party
may be entitled. 
 11.8 Broker’s Fee. Each of the Company and the Purchaser hereby represents that, there are no brokers
or finders entitled to compensation in connection with the sale of the Shares, and shall indemnify the other party for any such fees for which such party is responsible. 
 11.9 Notices. Any notice to be given under this Agreement must be in writing and delivered either in person, by any method of mail (postage prepaid) requiring return receipt, or by overnight courier or
facsimile confirmed thereafter by any of the foregoing, to the party to be notified at its address given below, or at any address such party has previously designated by prior written notice to the other. Notice shall be deemed sufficiently given
for all purposes upon the earliest of: (a) the date of actual receipt; (b) if mailed, three (7) days after the date of postmark; or (c) if delivered by overnight courier, the second business day the overnight courier regularly
makes deliveries. 
  

	 	(a)	If to the Company, notices must be addressed to: 

 Vical
Incorporated 
 10390 Pacific Center Court 
 San Diego, CA 92121 
 Attention: Vice President, Business Development 
 Telephone: 858-646-1144 
 Facsimile:
858-646-1152 
  

 21. 

	 	(b)	If to the Purchaser, notices must be addressed to: 

 AnGes MG, Inc. 
 5F, Mita Suzuki Bldg., 5-20-14 
 Shiba, Minato-ku, Tokyo, 108-0014 
 Japan 
 Telephone: 81-3-5730-2489 
 Facsimile:
81-3-5730-2635 
 11.10 Headings. The headings of the various sections of this Agreement have been inserted for convenience of
reference only and shall not be deemed to be part of this Agreement. 
 11.11 Disclaimer. EXCEPT AS EXPRESSLY SET FORTH IN THIS
AGREEMENT AND THE R&D AGREEMENT, NEITHER PARTY MAKES ANY REPRESENTATION OR WARRANTY TO THE OTHER PARTY OF ANY NATURE, EXPRESS OR IMPLIED. 
 11.12 Limitation of Liability. NEITHER PARTY SHALL BE ENTITLED TO RECOVER FROM THE OTHER PARTY ANY SPECIAL, INCIDENTAL, CONSEQUENTIAL OR PUNITIVE DAMAGES IN CONNECTION WITH THIS AGREEMENT. 
 [SIGNATURE PAGE TO FOLLOW] 
  

 22. 

 IN WITNESS WHEREOF, the parties hereto
have caused this Agreement to be executed by their duly authorized representatives as of the day and year first above written. 
  

			
	VICAL INCORPORATED
		
	By:	 	/s/ Jill M. Church
	Name:	 	Jill M. Church
	Title:	 	Chief Financial Officer

  

			
	ANGES MG, INC.
		
	By:	 	/s/ Ei Yamada
	Name:	 	Ei Yamada 
	Title:	 	President and CEO

 [Signature Page To Stock Purchase Agreement]Infineon TCC License Agreement, by and between Tessera and Infineon

 Exhibit 10.1 
 TESSERA, INC. 
 Infineon TCC® License Agreement 
 This
Agreement is entered into as of this First day of July, 2006 (“Effective Date”), between TESSERA INC., a corporation organized under the laws of Delaware, having a principal place of business at 3099 Orchard Drive, San Jose, CA, 95134, USA
and the Tessera Affiliates (“Tessera”) and Infineon Technologies AG, a corporation organized under the laws of Germany having a principal place of business at Munich, Germany and the Licensee Affiliates (“Licensee”) with
reference to the following facts: 
 Recitals 
 WHEREAS, Tessera owns certain patents related to semiconductor integrated circuit (“IC”) packaging technology, and 
 WHEREAS, Licensee
wishes to license the Tessera patents for certain semiconductor products in accordance with the terms hereof. 
 The Parties
Hereto Agree: 
 I. Definitions. As used herein, the following terms shall have the following meaning: 
 A. The term “Licensed Product” includes IC packages using (a) polyimide or glass-epoxy or glass-laminate substrate; (b) one or more
solder balls under the IC; (c) die attach adhesive attaching the IC to the polyimide or glass-epoxy or glass-laminate substrate; and (d) solder ball pitch less than or equal to 1.0mm. By way of clarification and not limitation, Licensed
Products include DRAM Licensed Products, Non-DRAM Licensed Products and Multiple Substrate Licensed Products. 
 B. The term “DRAM
Device” means a Dynamic Random Access Memory (DRAM) IC device comprised solely of an array of DRAM cells and the associated control and I/O circuitry that are necessary to allow data to be written to, stored by, and read from the DRAM cells.

 C. The term “DRAM Licensed Product” means a Licensed Product that contains at least one IC that is a DRAM Device and does not
contain an IC that is not a DRAM Device. 
 D. The term “Non-DRAM Licensed Product” means a Licensed Product that contains at least
one IC that is not a DRAM Device. If a Licensed Product contains both a DRAM Device and an IC that is not a DRAM Device, the Licensed Product shall be considered a Non-DRAM Licensed Product. 
 E. The term “Multiple Substrate Licensed Product” means a “Package Stack Unit” and a “Package Stack,” defined respectively
as follows: 
 i. The term “Package Stack Unit” means a package substrate having electrically conductive terminals and at least one
IC device on the package substrate and electrically connected to at least some of the terminals, and 
  

 Page 1 of 11 

 ii. The term “Package Stack” means an IC package including two or more Package Stack Units,
wherein said units are stacked one above the other so that at least some of the terminals on mutually adjacent units in the stack are aligned with one another, mutually adjacent units being electrically interconnected to one another by joining
connectors formed at least in part from material bonded to the aligned terminals of such units. 
 F. The term “Batch Technology”
as used herein means any method, process, technique or Tessera Patent that covers any structures or processing methods for simultaneously forming, producing and/or connecting a plurality of electrical connections between contacts on an IC device and
substrate terminals of the IC package, including: (i) any method or result of U.S. Patent Number 5,518,964 (and related Patents) for making flexible electrically conducting element(s), joining said elements to electrical contact(s) on a
substantially planar electrical element such as a semiconductor integrated circuit, undiced IC wafer, or interconnect substrate, and forming said element(s) away from the plane of said contacts in a predetermined fashion into the flexible electrical
lead(s) of an IC package; (ii) any method or result of U.S. Patent 5,455,390 (and related Patents) for making and forming flexible conducting element(s) on a dielectric film and then simultaneously joining said elements to electrical contacts
on a substantially planar electrical element such as a semiconductor integrated circuit, undiced IC wafer or interconnect substrate to produce the flexible electrical leads of an IC package; and/or (iii) any method or result of further
invention or Patent made or acquired by Tessera during the term hereof covering any batch processing method for simultaneously forming, producing and/or connecting a plurality of flexible electrical leads of an IC package. Notwithstanding, the
parties expressly agree that any IC package made and/or connected individually on a semiconductor integrated circuit or undiced wafer by traditional wire bonding methods and/or tape automated bonding (“TAB”) gang bonding methods, is
not included in Batch Technology. 
 G. The term “Patent” means letters patent, utility models, allowances and
applications therefor in all countries of the world, including re-issues, re-examinations, continuations, continuations-in-part, divisionals, and all corresponding foreign patents. 
 H. The term “Tessera Patent” means Patent(s) or claims within such Patent(s) for the design, manufacture, and/or assembly of Licensed Products
(excluding Batch Technology as defined herein) owned by Tessera prior to expiration or termination of this Agreement. The term Tessera Patent shall further include any third party patent for the design, manufacture, and/or assembly of Licensed
Products (excluding Batch Technology as defined herein) under which Tessera or any successor thereof has the right to grant licenses of the scope granted herein, as of the Effective Date or at any time during the term of this Agreement, without the
payment of royalty or other consideration to such third parties except for payment to third parties for inventions made by said parties while employed by Tessera or any successor thereof. Tessera Patents, as defined above, includes but is not
limited to those Patents set forth in Attachment A as of the date stated therein. Tessera has sole discretion in the prosecution of the Tessera patent applications licensed hereunder, non-exclusively including filing continuations,
continuations-in-part, divisionals, filing corresponding foreign patents applications and/or abandoning one or more of such patent applications. 
 I. The term “Billable Pin” means any electrical connection to an IC electrical bond pad made or contained in any Licensed Product. 
  

 Page 2 of 11 

 J. The term “Licensee Affiliate” means any company which agrees to be bound by the terms and
conditions of this Agreement and has more than fifty percent (50%) of the voting stock or equity owned or controlled by Licensee. A company shall be considered a Licensee Affiliate only so long as such majority ownership or control exists.
Licensee shall be ultimately responsible for the actions of the Licensee Affiliates pursuant to this Agreement. 
 K. The term “Tessera
Affiliate” means any company which agrees to be bound by the terms and conditions of this Agreement and has more than fifty percent (50%) of the voting stock or equity owned or controlled by Tessera. A company shall be considered a Tessera
Affiliate only so long as such majority ownership or control exists. Tessera shall be ultimately responsible for the actions of the Tessera Affiliates pursuant to this Agreement. 
 L. The term “Licensed Package Assembler” means a party licensed by Tessera to assemble, use and sell Licensed Products for others. Tessera
agrees to periodically provide Licensee a list of such parties. 
 II. Licensee Rights 
 A. License Grant. Subject to the terms and conditions hereinafter set forth, Licensee’s compliance with the provisions hereof including all
Attachments hereto, and Licensee’s payment of the fees and royalties stated herein in Paragraph III, Tessera hereby grants Licensee a world-wide, non-exclusive, non-transferable, non-sublicensable, limited license to the Tessera Patents to
make, have made, use, sell, import, and offer for sale Licensed Products that are sold as Licensee’s own products (i.e., the Licensed Products bear the Licensee’s commercial indicia). 
 1. Have Made Rights and Royalties. If Licensee exercises its “have made” right hereunder, Licensee shall be responsible for the payment
of all royalties due hereunder directly to Tessera for such assembly of Licensed Products regardless of whether or not the assembler of the Licensed Product is a Licensed Package Assembler. Nothing in this Paragraph II.A.1 shall prevent Licensee
from agreeing with a Licensed Package Assembler that the Licensed Package Assembler shall report and pay royalties to Tessera under its license for all Licensed Products made for Licensee provided, however, that if such Licensed Package Assembler
fails to report and pay such royalties, Licensee shall pay the unpaid royalties under this Agreement promptly upon notice by Tessera. Licensee shall have no obligation to pay an additional royalty under this agreement for products on which a
Licensed Package Assembler has already paid a full royalty under its agreement with Tessera. Any such agreement reached between Licensee and a Licensed Package Assembler shall require such Licensed Package Assembler to clearly identify Licensed
Products made for Licensee in reports to Tessera, and Tessera shall be given notice of such agreement. 
 2. Notice to Assemblers.
When Licensee exercises this “have made” right at a Package Assembler, it shall provide a written notice to such Licensed Package Assembler, with a copy to Tessera, substantially in the form attached hereto as Attachment D. 

B. Batch Technology Excluded. Notwithstanding anything herein to the contrary, Batch Technology is excluded from the scope of this Agreement,
and Licensee’s rights herein expressly exclude any right to package and/or assemble, or sell any product made using Batch Technology. Accordingly, products made using Batch Technology are not Licensed Products under this Agreement, and no
royalties are due under this Agreement for products made using Batch Technology. 
  

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 C. No Implied License. Except for the licenses expressly granted in Paragraph II.A, no license,
express or implied, by estoppel or otherwise, to any of Tessera’s intellectual property rights is granted or implied by this Agreement. 
 D. Exclusion from License. Licensee is licensed only for Licensed Products for which it pays royalties hereunder. Tessera may, at any time during the term hereof, notify Licensee that Tessera believes that a product made, used, sold,
imported, or offered for sale by Licensee (“Notified Product”) is a Licensed Product. During a sixty (60) day period after such notice, the parties will engage in good faith negotiations to include the Notified Product hereunder as
Licensed Product, but neither party will commence any litigation or administrative proceedings relating to the Notified Product until after the end of the sixty (60) day period. If the parties fail to agree on including the Notified Product as
a Licensed Product during such period, the Notified Product will not be licensed hereunder and either party may commence litigation or administrative proceedings upon the expiration of the sixty (60) day period. 
 III. Royalty and Other Consideration 
 A. Other Consideration. As partial consideration for the license under this Agreement, Licensee shall pay to Tessera the sum of Ten Million US Dollars ($10,000,000) by August 18, 2006. 
 B. Royalty. As further consideration Licensee shall pay running royalties for the license granted under this Agreement four times annually (as set
forth in Paragraph V) to Tessera during the term of this Agreement, as follows: 
 1. DRAM Licensed Products. For each DRAM Licensed
Product sold by Licensee, Licensee shall pay a royalty as set forth in Attachment B. 
 2. Non-DRAM Licensed Products. For each
Non-DRAM Licensed Product sold by Licensee, Licensee shall pay a royalty as set forth in Attachment B. 
 3. Multiple Substrate Licensed
Products. In the case of a Multiple Substrate Licensed Product, royalties due under this Paragraph III.B shall be calculated separately for each Package Stack Unit of a Package Stack based on whether the Package Stack Unit solely contains DRAM
or includes other types of ICs. For example, the royalty due for a Package Stack Unit that contains solely DRAM shall be determined according to Paragraph III.B.1 per Package Stack Unit, the royalty due for a Package Stack Unit that contains an IC
that is not DRAM shall be determined according to Paragraph III.B.2 per Package Stack Unit, such that the total royalty due for a Multiple Substrate Licensed Product shall be calculated by adding together the royalty determined for each Package
Stack Unit. 
 C. Royalty Adjustments. In making the royalty payments due Tessera, Licensee may subtract from such royalty payments
any preceding royalty payments for royalty bearing Licensed Products that are returned to Licensee from Licensee’s customers (“Royalty Adjustment”). 
  

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 However, if at any time such returned Licensed Products are resold by Licensee, Licensee shall pay a royalty to Tessera
for such resold Licensed Products, as set forth in the Agreement. Before a Royalty Adjustment can be so subtracted, Licensee must have originally paid a royalty on the particular returned Licensed Product. All Royalty Adjustments must be specified
with the information set forth in Attachment C. 
 IV. Taxes 
 Any taxes due to the German government relating to payments made by Licensee to Tessera pursuant to this Agreement shall be paid by Licensee and deducted
from the amount payable from Licensee to Tessera. Licensee shall obtain official tax receipts from the German government indicating payment of such taxes and submit such receipts to Tessera to enable Tessera to obtain applicable tax credits.
Licensee shall cooperate reasonably with Tessera, and offer such assistance as it reasonably can, in order to ensure that Tessera receives the most favorable tax treatment with respect to the payments detailed herein. 
 V. Licensee Reports and Payment 
 A.
Quarterly Royalty Reports & Payment. Beginning on the Effective Date of this Agreement, royalties shall be calculated and paid in full in quarter annual payment periods ending March 31, June 30, September 30
and December 31 of each year. Beginning with the first such royalty payment, Licensee shall deliver a written report (as shown in Attachment C) describing (i) the basis upon which and containing the information sufficient to determine the
royalties due Tessera for the applicable payment period and (ii) the purchases by Licensee of Licensed Products from other Tessera licensees. All payments under this Paragraph shall be made in US Dollars by wire transfer to Union Bank of
California, 99 Almaden Blvd., San Jose, CA 95113, Account Name: Tessera, Account No.: 6450148359, Routing No. 122000496, International Swift Code: BOFCUS33MPK, or such other bank or account as Tessera may from time to time designate in writing.
The payments of royalties and submission of such reports from Licensee to Tessera under this Paragraph shall be made within thirty (30) days from the end of each quarter annual payment period and shall be considered to be made as of the day on
which such payments are received in Tessera’s designated bank account. 
  

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 VI. Licensee Patents 
 A. Limited Rights Under Licensee’s Patents. Licensee hereby grants to Tessera a world-wide, royalty-free, non-exclusive, non-sublicensable, non-transferable, right under Licensee’s Patents for the
term of this Agreement to make, use and sell Licensed Products (subject to the Batch Technology exclusion of Paragraph II.B) for the purposes of internal research and development, customer funded research and development, and in support of
Tessera’s engineering services business. For the sake of clarity, the license granted to Tessera in this Section VI.A is limited to the IC package and interconnect of the Licensed Product, alone or in combination with an IC, and does not
include, for example, the functional circuitry on the die or semiconductor process technology used in the formation of the functional circuitry on the IC (hereafter “Infineon License Scope”). If Licensee elects to extend the term of this
Agreement to obtain a paid-up license, then the license set forth in this Paragraph VI.A shall also become a fully paid-up and perpetual. Furthermore, to the extent that Licensee believes a third party is directly infringing Licensee’s patents
within the Infineon License Scope, Licensee agrees to pursue its claims directly with such third party and not with Tessera unless Tessera first asserts a Tessera Patent against Licensee that would require an additional royalty for Licensed Products
made under this Agreement. 
 VII. This section intentionally left blank 
 VIII. Term and Termination 
 A.
Term: This Agreement shall become effective on the Effective Date and, unless earlier terminated as provided for elsewhere in this Agreement, shall remain in full force until it automatically expires on May 22, 2012, unless Licensee
notifies Tessera by November 22, 2011 that Licensee elects to extend this Agreement by five (5) years until May 22, 2017, and continue to pay royalties for Licensed Products during the five (5) year extension period at rates
equal to fifty percent (50%) of the amounts due under Paragraph III.B. herein. If Licensee elects to extend this Agreement until May 22, 2017, upon expiration of the extended term, Licensee shall have a fully paid-up and perpetual license
on the terms set forth in Paragraphs II.A through II.D herein to use the Tessera Patents to the same extent as Licensee was licensed to use and was using Tessera Patents immediately prior to such expiration. 
 B. Termination for Breach. Either party may terminate this Agreement due to the other party’s breach of this Agreement, such as failure to
perform its duties, obligations, or responsibilities herein (including, without limitation, failure to pay fees and royalties and provide reports as set forth herein). The parties agree that such breach will cause substantial damages to the party
not in breach. Therefore, the parties agree to work together to mitigate the effect of any such breach; however, the non-breaching party may terminate this Agreement if such breach is not cured or sufficiently mitigated (to the non-breaching
party’s satisfaction) within sixty (60) days of notice thereof. 
 C. Termination for Assignment. In the event that
(i) a party either sells or assigns substantially all of its assets or business to a third party (“Selling Party”) or (ii) a third party acquires more than fifty percent (50%) of the capital stock entitled to vote for
directors of such party (“Purchasing Party”), the Selling Party shall notify the other party hereto of such sale or assignment of assets or the Purchasing Party’s acquisition. In any case of sale, assignment or 
  

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 acquisition, the Selling Party shall provide to the other party a written confirmation from such Purchasing Party stating
that such Purchasing Party shall expressly undertakes all the terms and conditions of this Agreement to be performed by Selling Party. In the event that Licensee is the Selling Party and the Purchasing Party does not agree to fulfill such
obligations under this Agreement, Tessera shall reserve a right to terminate this Agreement. In the event Tessera is the Selling Party, the Purchasing Party shall be bound to the terms and obligations of this Agreement. 
 D. Termination for Bankruptcy. In the event that one party becomes insolvent or bankrupt, permanently ceases doing business, makes an assignment
for the benefit of its creditors, commits an act of bankruptcy, commences any bankruptcy proceedings or other proceedings in the nature of bankruptcy proceedings, or has commenced against it any bankruptcy proceedings or other proceedings in the
nature of bankruptcy proceedings that are not dismissed within sixty (60) days, then the other party shall have the right to terminate this Agreement immediately upon its notice. 
 E. Effect of Termination. Any termination of this Agreement pursuant to this Paragraph VIII shall be deemed a termination of this Agreement in
accordance with its terms (including termination of any payments of unaccrued royalties to Tessera and any rights of Licensee to use any Tessera Patent licensed hereunder). 
 F. Survival Clause. Unless otherwise provided elsewhere in this Agreement, the following provisions shall survive the termination or expiration of
this Agreement: 
 1. Licensee’s obligation to make payments to Tessera accrued under this Agreement on or prior to expiration or
termination. 
 2. Licensee’s obligation to submit written reports stipulated in Paragraph V for periods prior to termination, Licensee
Reports and Payment, and to permit the inspection and audit of its records stipulated in Paragraph IX, Reasonable Audit. 
 3. Paragraph
VIII, Term and Termination. 
 4. Paragraph X, No Warranties 
 5. Paragraph XI, Limitation on Damages 
 6. Paragraph XII, Confidentiality of Agreement Terms 
 7. Paragraph XIV, Miscellaneous 
 IX.
Reasonable Audit 
 A. Financial Audit. Upon reasonable written prior notice, Tessera shall have the right to examine and audit
through an independent third party CPA firm, not more frequently than once per year, relevant records of Licensee that may contain information bearing upon the amount of fees and royalties payable under this Agreement; provided, that the said
auditor shall have agreed in advance in writing to maintain in confidence and not to disclose to Tessera or any third party any 
  

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 Licensee proprietary information obtained during the course of such audit. Licensee shall permit auditors to copy and
retain audit relevant records in confidence. The results of any such audit shall be final, and within thirty (30) days after receiving the auditor’s report, Licensee shall make payment to Tessera of any amount which may be found to be
payable, if any, and Tessera shall make payment to Licensee of any amount which may be found to have been overpaid, if any. Tessera shall bear the expenses of such audit examinations unless fees and royalties due and owing to Tessera are determined
by the auditor to be at least five percent (5%) greater than such similar amounts as calculated and/or paid by Licensee, in which case Licensee shall bear such expenses. 
 X. No Warranties 
 The Parties
acknowledge and agree that the rights and licenses, Tessera Patents, Licensee patents and standards granted or otherwise provided hereunder are provided “AS IS”, with no warranty of any kind. NEITHER PARTY MAKES ANY WARRANTY, EXPRESS,
IMPLIED, STATUTORY OR OTHERWISE, CONCERNING THE SUBJECT MATTER OF THIS AGREEMENT, INCLUDING WITHOUT LIMITATION, WARRANTIES OF FITNESS FOR A PARTICULAR PURPOSE, QUALITY, USEFULNESS, PATENT VALIDITY OR NONINFRINGEMENT. Neither Party makes any warranty
that the Tessera Patents or the Licensee patents will be sufficient to yield any particular result. 
 XI. Limitation on Damages

 IN NO EVENT SHALL EITHER PARTY BE LIABLE TO THE OTHER PARTY OR ANY OTHER PERSON OR ENTITY (UNDER ANY CONTRACT, NEGLIGENCE, STRICT
LIABILITY OR OTHER THEORY) FOR SPECIAL, INCIDENTAL OR CONSEQUENTIAL DAMAGES ARISING OUT OF OR RELATED TO THE SUBJECT MATTER OF THIS AGREEMENT, EVEN IF THE PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGES OR LOSSES. 
 XII. Confidentiality of Agreement Terms 
 A. Confidential Terms. Tessera and Licensee shall keep the terms of this Agreement (including all Attachments hereto) confidential except: 
 (1) to any court or governmental body or agency compelling such disclosure; however, any disclosure shall be limited to that compelled by the governmental body or agency and the disclosing party will take all
reasonable actions to obtain a protective order protecting the disclosure. With respect to any disclosure to of this Agreement required by the United States Securities and Exchange Commission or similar governmental agencies (it being acknowledged
and agreed that Licensee will file this Agreement as an exhibit to the registration statement on form F-1 it has filed with respect to its initial public offering), Licensee shall use reasonable efforts to secure confidential treatment of the
royalty terms set forth in Attachment B hereto, provided, however, that, if after making such reasonable efforts Licensee is unable to secure such confidential treatment without adversely effecting the timing of the planned initial public offering
of Qimonda AG, then Licensee need not secure such confidential treatment of the royalty terms; 
 (2) as may otherwise be required by law;

 (3) disclosures to their respective attorneys, accountants, and financial advisors; or 
  

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 (4) either party may disclose to third parties the existence of this Agreement to the extent described in
the Recitals section hereof. 
 B. Order to Disclose. A party receiving a request, subpoena or order for the disclosure of the terms
or conditions of this Agreement shall notify the other party as soon as practicable and if, at all possible, in sufficient time to allow the other party to oppose disclose or seek appropriate protective orders. The party receiving such request,
subpoena or order shall cooperate to the extent reasonably possible with the other party in any effort to oppose disclosure or seek protective orders. 
 C. Breach of Confidentiality. If either party learns of a breach of this Paragraph XII, such party shall immediately send a written notification to the other party describing the circumstances of such breach.

 D. Employee Agreements. Licensee will disclose the terms of this Agreement solely to its employees who have a need to know such
information. 
 E. Prior Confidentiality Terms. This Paragraph XII applies only to the matters described herein and does not supersede
any prior written agreements between the parties. 
 XIII. This Section Intentionally Left Blank 
 XIV. Miscellaneous 
 The following
additional terms shall apply to this Agreement: 
 A. Governing Law. This Agreement shall be governed, interpreted and construed in
accordance with the laws of the State of California, irrespective of choice of laws provisions. Both parties shall use reasonable efforts to resolve by mutual agreement any disputes, controversies, claims or difference which may arise from, under,
out of or in connection with this Agreement. If such disputes, controversies, claims or differences cannot be settled between the parties, any dispute resolution proceeding shall take place in the United States, but if either party files a claim in
a state or federal court, such claim shall be filed in the state or federal courts within the geographic boundaries of the federal Eastern District of Texas. The parties hereby consent to personal jurisdiction and venue in the state and federal
courts of the federal Eastern District of Texas. Nothing herein shall alter or affect any other rights either party may have to redress any breach or act of the other party. Notwithstanding any provision herein, after the sixty (60) day cure
period set forth in Paragraph VIII.B and notice of termination of this Agreement by one of the parties, either party may bring an action in the U.S. International Trade Commission. 
 B. No Waiver. Any waiver, express or implied, by either of the parties hereto of any right hereunder or default by the other party, shall not
constitute or be deemed a continuing waiver or a waiver of any other right or default. No failure or delay on the part of either party in the exercise of any right or privilege hereunder shall operate as waiver thereof, nor shall any single or
partial exercise of such right or privilege preclude other or further exercise thereof or of any other right or privilege. 
  

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 C. Equitable Relief. Nothing herein shall preclude either party from taking actions at any time in
the courts specified in Paragraph XIV.A that are necessary to prevent immediate, irreparable harm to its interests. Otherwise, these procedures are exclusive and shall be fully exhausted prior to the initiation of any litigation. 
 D. Notices. All notices, required documentation, and correspondence in connection herewith shall be in the English language, shall be provided in
writing and shall be given by facsimile transmission or by registered or certified letter to Tessera and Licensee at the addresses and facsimile numbers set forth below: 
  

			
	Tessera:	  	Tessera, Inc.
		  	3099 Orchard Dr.
		  	San Jose, California 95134
		  	Facsimile No.: 408-894-0190
		  	Attn.: Chief Executive Officer
		
	Licensee:	  	Infineon Technologies AG
		  	Am Campeon 1-12
		  	85579 Neubiberg,
		  	Germany
		  	Facsimile No.: +49 89 234 955 4659
		  	Att.: General Counsel

 Either Party may change its address and/or facsimile number by giving the other party notice of
such new address and/or facsimile number. All notices if given or made by registered or certified letter shall be deemed to have been received on the earlier of the date actually received and the date three days after the same was posted and if
given or made by facsimile transmission shall be deemed to have been received at the time of dispatch, unless such date of receipt is not a business day, in which case the date of deemed receipt shall be the next succeeding business day. 

E. Invalidity. If any provision of this Agreement is declared invalid or unenforceable by a court having competent jurisdiction, it is mutually
agreed that this Agreement shall endure except for the part declared invalid or unenforceable by order of such court. The parties shall consult and use their reasonable efforts to agree upon a valid and enforceable provision which shall be a
reasonable substitute for such invalid or unenforceable provision in light of the intent of this Agreement. 
 F. Assignment. With the
exception of Paragraph VIII.C (Termination for Assignment), neither party may assign this Agreement or any of its rights or obligations hereunder without the prior written consent of the other party; provided, however, that Tessera may assign this
Agreement to a Tessera Affiliate, a parent company, or any company owned or controlled by such parent company. 
 G. Export
Regulations. Both parties shall comply with the laws and regulations of the government of the United States and of any other country as relevant to each party hereto relating to the export of goods and information. 
  

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 H. Paragraph Headings. The headings and captions used herein shall not be used to interpret or
construe this Agreement. 
 I. Entire Understanding. This Agreement embodies the entire understanding between the parties relating to
the subject matter hereof, whether written or oral, and there are no prior representations, warranties or agreements between the parties not contained in this Agreement. Any amendment or modification of any provision of this Agreement must be in
writing, dated and signed by both parties hereto. 
 J. Contingency. This Agreement shall not become effective unless and until
Tessera’s Executive Committee (consisting of Tessera’s Chief Executive Officer, Chief Financial Officer and General Counsel) confirms acceptance of this Agreement on August 1, 2006, between 3:00 pm and 4:00 pm EDT. Tessera will use
reasonable efforts to inform Licensee (by e-mail or facsimile) of acceptance by Tessera’s Executive Committee within an hour of such acceptance, provided, however, that Tessera shall not publish a press release prior to delivery of such
information to Infineon. 
 IN WITNESS WHEREOF, the parties hereto have executed and delivered this Agreement as of the date first above
written. 
  

									
	TESSERA, INC.	 		 	INFINEON TECHNOLOGIES AG
					
	By:	 	 /s/ Christopher Pickett
	 		 	By:	 	 /s/ V. Eickstedt Stang

	Print Name:	 	Christopher Pickett	 		 	Print Name:	 	V. Eickstedt Stang
	Title:	 	EVP and General Counsel	 		 	Title:	 	General Counsel, Corporate Counsel
	Date:	 	July 31, 2006	 		 	Date:	 	August 1, 2006

  

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