Document:

Exhibit 10.1

 Exhibit 10.1 
 2003 INCENTIVE AWARD PLAN 
 EMPLOYEE STOCK OPTION AGREEMENT

 (Adopted Effective as of February 8, 2012) 
 THIS AGREEMENT, dated the Grant Date set forth on the Stock Option Grant Notice (“Grant Notice”) (the terms of which are incorporated by reference and made a part of this Agreement), is made by
and between Gen-Probe Incorporated, a Delaware corporation, hereinafter referred to as the “Company,” and the Employee of the Company, or a Subsidiary of the Company, identified on the Grant Notice and hereinafter referred to as
“Optionee.” 
 WHEREAS, the Company wishes to afford the Optionee the opportunity to purchase shares of its Common
Stock, par value $0.0001 per share; and 
 WHEREAS, the Company wishes to carry out The 2003 Incentive Award Plan of Gen-Probe
Incorporated (the “Plan”) (the terms of which are hereby incorporated by reference and made a part of this Agreement); and 
 WHEREAS, the Committee, appointed to administer the Plan, has determined that it would be to the advantage and best interest of the Company and its stockholders to grant the Stock Option (the
“Option”) provided for herein to the Optionee as an inducement to enter into or remain in the service of the Company or its Subsidiaries and as an incentive during such service, and has advised the Company thereof and instructed the
undersigned officer to issue said Option. 
 NOW, THEREFORE, in consideration of the mutual covenants herein contained and other
good and valuable consideration, the receipt of which is hereby acknowledged, the parties hereto do hereby agree as follows: 

ARTICLE I 

DEFINITIONS 
 1.1 General. Wherever the following terms are used in this Agreement they shall have the meanings specified below, unless the context clearly indicates otherwise. 

1.2 Board. “Board” shall mean the Board of Directors of the Company. 

1.3 Cause. “Cause” shall mean any of the following events: (i) any act of gross or willful misconduct, fraud,
misappropriation, dishonesty, embezzlement or similar conduct on the part of Optionee; (ii) Optionee’s conviction of a felony or any crime involving moral turpitude (which conviction, due to the passage of time or otherwise, is not subject
to further appeal); (iii) Optionee’s misuse or abuse of alcohol, drugs or controlled substances and failure to seek and comply with appropriate treatment; 

  
 1. 

 
(iv) willful and continued failure by Optionee to substantially perform his or her duties with respect to Optionee’s employment with or service to the Company (other than any failure
resulting from disability or from termination by Optionee for Good Reason) as determined by a majority of the Board after written demand from the Board for substantial performance is delivered to Optionee, and Optionee fails to resume substantial
performance of his or her duties on a continuous basis within thirty (30) days of such notice; (v) the death of Optionee; or (vi) Optionee becoming disabled such that Optionee is not able to perform his or her usual duties for the
Company for a period in excess of six (6) consecutive calendar months. Notwithstanding anything to the contrary above, if Optionee is party to an employment or other agreement with the Company that contains a different definition of
“Cause,” such definition as set forth in Optionee’s employment or other agreement with the Company shall control. 
 1.4 Code. “Code” shall mean the Internal Revenue Code of 1986, as amended from time to time. 
 1.5 Committee. “Committee” shall mean the Compensation Committee of the Board, or a subcommittee of the Board, appointed as provided in Section 9.1 of the Plan. 

1.6 Common Stock. “Common Stock” shall mean the Common Stock of the Company, par value $0.0001 per share. 

1.7 Company. “Company” shall mean Gen-Probe Incorporated, a Delaware corporation. 

1.8 Director. “Director” shall mean a member of the Board, whether such Director is an Employee or an Independent Director (as
defined in the Plan). 
 1.9 Employee. “Employee” shall mean any officer or other employee (as defined in accordance
with Section 3401(c) of the Code) of the Company, or of any Subsidiary. 
 1.10 Exchange Act. “Exchange Act”
shall mean the Securities Exchange Act of 1934, as amended. 
 1.11 Fair Market Value. “Fair Market Value” shall mean,
as of any date, the value of the Common Stock determined as follows: 
 (a) If the Common Stock is listed on any established
stock exchange or a national market system, the Fair Market Value of a share of Common Stock shall be the closing sales price for such stock (or the closing bid, if no sales were reported) as quoted on such exchange or system (or the exchange or
system with the greatest volume of trading in the Common Stock) for such date, or if no bids or sales were reported for such date, then the closing sales price (or the closing bid, if no sales were reported) on the trading date immediately prior to
such date during which a bid or sale occurred, in each case, as reported by The Nasdaq Stock Market or such other source as the Board deems reliable. 

  
 2. 

 (b) In the absence of such markets for the Common Stock, the Fair Market Value shall be
determined in good faith by the Board. 
 1.12 Good Reason. “Good Reason” shall mean any of the following events that
are not consented to by Optionee: (i) a substantial and material diminution in Optionee’s duties and responsibilities with respect to Optionee’s employment with or service to the Company; (ii) the location of Optionee’s
assignment on behalf of the Company is moved to a location more than thirty (30) miles from its present location; (iii) a reduction of more than ten percent (10%) in Optionee’s base salary; (iv) the failure of the Company to
obtain a satisfactory agreement from any other successor to the Company to assume and agree to perform this Agreement as applicable; or (v) a material breach by the Company of its obligations under this Agreement after notice in writing from
Optionee and a reasonable opportunity for the Company to cure or substantially mitigate any material adverse effect of such breach; provided that, in the case of (i)-(v) above: (a) Optionee notified the Company of his or her intent
to resign for Good Reason within ninety (90) days of the initial existence of the condition giving rise to Good Reason (a “Good Reason Condition”); (b) Optionee provided the Company with a period of thirty (30) days during
which it may remedy the Good Reason Condition; (c) the Company did not remedy the Good Reason Condition during such period; (d) Optionee terminated for Good Reason based on the condition specified in the notice; and (e) such
resignation occurs within one year after the initial existence of such Good Reason Condition. Notwithstanding anything to the contrary above, if Optionee is party to an employment or other agreement with the Company that contains a different
definition of “Good Reason,” such definition as set forth in Optionee’s employment or other agreement with the Company shall control. 
 1.13 Option. “Option” shall mean the Stock Option granted under this Agreement and Article IV of the Plan. 
 1.14 Optionee. “Optionee” shall mean the Employee granted the Option under this Agreement and the Plan. 
 1.15 Plan. “Plan” shall mean The 2003 Incentive Award Plan of Gen-Probe Incorporated, as amended from time to time. 
 1.16 Retirement. “Retirement” shall mean the Optionee’s resignation after the Optionee has attained age 60 and completed ten (10) or more years of employment with the Company and the
Subsidiaries. 
 1.17 Secretary. “Secretary” shall mean the Secretary of the Company. 

1.18 Securities Act. “Securities Act” shall mean the Securities Act of 1933, as amended. 

  
 3. 

 1.19 Subsidiary. “Subsidiary” shall mean any corporation in an unbroken chain of
corporations beginning with the Company if each of the corporations other than the last corporation in the unbroken chain then owns stock possessing fifty percent (50%) or more of the total combined voting power of all classes of stock in one
of the other corporations in such chain. 
 1.20 Termination of Employment. “Termination of Employment” shall mean the
time when the employee-employer relationship between the Optionee and the Company or any Subsidiary is terminated for any reason, with or without Cause, including, but not by way of limitation, a termination by resignation, discharge, death,
disability or Retirement; but excluding (a) a termination where there is a simultaneous reemployment or continuing employment of the Optionee by the Company or any Subsidiary or a parent corporation thereof (within the meaning of
Section 422 of the Code), (b) at the discretion of the Committee, a termination which results in a temporary severance of the employee-employer relationship, (c) at the discretion of the Committee, a termination which is followed by
the simultaneous establishment of a consulting relationship by the Company or a Subsidiary with the former employee until the consultancy terminates and (d) terminations of employment due to retirement which are followed by the continuing
service of the Holder as a Director of the Company, until such service as a director terminates. The Committee, in its absolute discretion, shall determine the effect of all matters and questions relating to Termination of Employment, including, but
not by way of limitation, the question of whether a Termination of Employment resulted from a discharge for Cause, and all questions of whether particular leaves of absence constitute Terminations of Employment; provided, however, that, if this
Option is designated as an Incentive Stock Option, unless otherwise determined by the Administrator in its discretion, a leave of absence, change in status from an employee to an independent contractor or other change in the employee-employer
relationship shall constitute a Termination of Employment if, and to the extent that, such leave of absence, change in status or other change interrupts employment for the purposes of Section 422(a)(2) of the Code and the then applicable
regulations and revenue rulings under said Section. Notwithstanding any other provision of the Plan or this Agreement, the Company or any Subsidiary has an absolute and unrestricted right to terminate the Optionee’s employment at any time for
any reason whatsoever, with or without Cause, except to the extent expressly provided otherwise in writing. 
 ARTICLE II

 GRANT OF OPTION 
 2.1 Grant of Option. In consideration of the Optionee’s agreement to remain in the employ of the Company or its Subsidiaries and for other good and valuable consideration, effective as of the Date of
Grant set forth on the Grant Notice, the Company irrevocably grants to the Optionee the option to purchase any part or all of an aggregate of the number of shares of Common Stock set forth on the Grant Notice, upon the terms and conditions set forth
in this Agreement. The Option shall be either an Incentive Stock Option or a Non-Qualified Stock Option, as set forth on the Grant Notice. 

  
 4. 

 2.2 Purchase Price. The purchase price of the shares of Common Stock subject to the Option
per share shall be as set forth on the Grant Notice, without commission or other charge; provided, however, that if this Option is designated as an Incentive Stock Option the price per share of the shares subject to the Option shall not be less than
the greater of (i) 100% of the Fair Market Value of a share of Common Stock on the Date of Grant, or (ii) 110% of the Fair Market Value of a share of Common Stock on the Date of Grant in the case of an Optionee then owning (within the
meaning of Section 424(d) of the Code) more than 10% of the total combined voting power of all classes of stock of the Company or any Subsidiary or parent corporation thereof (within the meaning of Section 422 of the Code). 

2.3 Consideration to the Company. In consideration of the granting of the Option by the Company, the Optionee agrees to render faithful
and efficient services to the Company or any Subsidiary, with such duties and responsibilities as the Company shall from time to time prescribe. Nothing in the Plan or this Agreement shall confer upon the Optionee any right to continue in the employ
of the Company or any Subsidiary or shall interfere with or restrict in any way the rights of the Company and its Subsidiaries, which are hereby expressly reserved, to discharge the Optionee at any time for any reason whatsoever, with or without
Cause. 
 ARTICLE III 
 PERIOD OF EXERCISABILITY 
 3.1 Commencement of Exercisability. 

(a) Subject to Sections 3.3 and 5.11, the Option shall become exercisable in such amounts and at such times as are set forth on the Grant
Notice. 
 (b) No portion of the Option which has not become exercisable at Termination of Employment shall thereafter become
exercisable, except as may be otherwise provided by the Committee. 
 3.2 Duration of Exercisability. The installments provided
for in Section 3.1(a) and the Grant Notice are cumulative. Each such installment which becomes exercisable pursuant to Section 3.1 shall remain exercisable until it becomes unexercisable under Section 3.3. 

3.3 Expiration of Option. The Option may not be exercised to any extent by anyone after the first to occur of the following events:

 (a) The expiration of seven (7) years from the Date of Grant; or 

  
 5. 

 (b) If this Option is designated as an Incentive Stock Option and the Optionee owned (within
the meaning of Section 424(d) of the Code), at the time the Option was granted, more than ten percent (10%) of the total combined voting power of all classes of stock of the Company or any Subsidiary or parent corporation thereof (within
the meaning of Section 422 of the Code), the expiration of five (5) years from the date the Option was granted; or 

(c) The expiration of three (3) months following the date of the Optionee’s Termination of Employment, unless such Termination
of Employment occurs by reason of the Optionee’s discharge for Cause, or by reason of the Optionee’s death, Retirement or disability (within the meaning of Section 22(e)(3) of the Code); or 

(d) The expiration of one (1) day following the date of the Optionee’s Termination of Employment by reason of the
Optionee’s discharge for Cause; or 
 (e) The expiration of six (6) months following the date of the Optionee’s
Termination of Employment by reason of the Optionee’s death or disability (within the meaning of Section 22(e)(3) of the Code); or 
 (f) The expiration of one (1) year following the date of the Optionee’s Termination of Employment by reason of the Optionee’s Retirement. 

3.4 Special Tax Consequences. The Optionee acknowledges that, to the extent that the aggregate Fair Market Value of stock with respect to
which “incentive stock options” (within the meaning of Section 422 of the Code, but without regard to Section 422(d) of the Code), including the Option, are exercisable for the first time by the Optionee during any calendar year
(under the Plan and all other incentive stock option plans of the Company, any Subsidiary and any parent corporation thereof (within the meaning of Section 422 of the Code)) exceeds $100,000, the Option and such other options shall be treated
as not qualifying under Section 422 of the Code but rather shall be taxed as non-qualified stock options. The Optionee further acknowledges that the rule set forth in the preceding sentence shall be applied by taking options into account in the
order in which they were granted. For purposes of these rules, the Fair Market Value of stock shall be determined as of the time the option with respect to such stock is granted. 

ARTICLE IV 

EXERCISE OF OPTION 
 4.1 Person Eligible to Exercise. Subject to Section 5.2, during the lifetime of the Optionee, only the Optionee may exercise the Option or any portion thereof. After the death of the Optionee, any
exercisable portion of the Option may, prior to the time when the Option becomes unexercisable under Section 3.3, be exercised by the Optionee’s personal representative or by any person empowered to do so under the Optionee’s will or
under the then applicable laws of descent and distribution. 

  
 6. 

 4.2 Partial Exercise. Any exercisable portion of the Option or the entire Option, if then
wholly exercisable, may be exercised in whole or in part at any time prior to the time when the Option or portion thereof becomes unexercisable under Section 3.3; provided, however, that each partial exercise shall be for not less than ten
(10) shares and shall be for whole shares only. 
 4.3 Manner of Exercise. Except as otherwise provided herein, the Option,
or any exercisable portion thereof, may be exercised solely by delivery to the Secretary or the Secretary’s office of all of the following prior to the time when the Option or such portion thereof becomes unexercisable under Section 3.3:

 (a) An Exercise Notice in writing signed by the Optionee or the other person then entitled to exercise the Option or portion
thereof, stating that the Option or portion thereof is thereby exercised, such notice complying with all applicable rules established by the Committee. Such notice shall be substantially in the form attached as Attachment III to the Grant
Notice (or such other form as is prescribed by the Committee); and 
 (b) (i) Full payment (in cash or by check) for the shares
with respect to which the Option or portion thereof is exercised, to the extent permitted under applicable laws; or 
 (ii) With the consent of the Committee, such payment may be made, in whole or in part, through the delivery of shares of Common Stock which have been owned by the Optionee for at least six months, duly
endorsed for transfer to the Company with a Fair Market Value on the date of delivery equal to the aggregate exercise price of the Option or exercised portion thereof; or 

(iii) To the extent permitted under applicable laws, through the delivery of a notice that the Optionee has placed a
market sell order with a broker with respect to shares of Common Stock then issuable upon exercise of the Option, and that the broker has been directed to pay a sufficient portion of the net proceeds of the sale to the Company in satisfaction of the
Option exercise price, provided, that payment of such proceeds is then made to the Company upon settlement of such sale; or 
 (iv) With the consent of the Committee, any combination of the consideration provided in the foregoing subparagraphs (i), (ii) and (iii); and 

(c) A bona fide written representation and agreement, in such form as is prescribed by the Committee, signed by the Optionee or other
person then entitled to exercise such Option or portion thereof, stating that the shares of Common Stock are being acquired for the Optionee’s own account, for investment and without any present intention of distributing or reselling said
shares or any of them except as may be permitted under the Securities Act and then applicable rules and regulations thereunder, and that the Optionee or other person then entitled to exercise such Option or portion thereof will indemnify the Company
against and hold it free and harmless from any loss, 

  
 7. 

 
damage, expense or liability resulting to the Company if any sale or distribution of the shares by such person is contrary to the representation and agreement referred to above. The Committee
may, in its absolute discretion, take whatever additional actions it deems appropriate to ensure the observance and performance of such representation and agreement and to effect compliance with the Securities Act and any other federal or state
securities laws or regulations. Without limiting the generality of the foregoing, the Committee may require an opinion of counsel acceptable to it to the effect that any subsequent transfer of shares acquired on an Option exercise does not violate
the Securities Act, and may issue stop-transfer orders covering such shares. Share certificates evidencing Common Stock issued on exercise of the Option shall bear an appropriate legend referring to the provisions of this subsection (c) and the
agreements herein. The written representation and agreement referred to in the first sentence of this subsection (c) shall, however, not be required if the shares to be issued pursuant to such exercise have been registered under the Securities
Act, and such registration is then effective in respect of such shares; and 
 (d) Full payment to the Company (or other
employer corporation) of all amounts which, under federal, state or local tax law, it is required to withhold upon exercise of the Option. With the consent of the Committee, (i) shares of Common Stock owned by the Optionee for at least six
months duly endorsed for transfer or (ii) shares of Common Stock issuable to the Optionee upon exercise of the Option, having a Fair Market Value at the date of Option exercise equal to the statutory minimum sums required to be withheld, may be
used to make all or part of such payment; and 
 (e) In the event the Option or portion thereof shall be exercised pursuant to
Section 4.1 by any person or persons other than the Optionee, appropriate proof of the right of such person or persons to exercise the Option. 
 (f) Notwithstanding anything to the contrary herein, if upon expiration of the Option as set forth in Section 3.3 above, (i) any portion of the Option that is then exercisable remains
unexercised and (ii) as of such expiration date the Fair Market Value is greater than the exercise price of the Option by at least one percent (1%), then the unexercised Option or portion thereof shall be automatically exercised as of the close
of business on such expiration date. In the event of such automatic exercise, payment for the Option shall be made through the surrender of shares of Common Stock then issuable upon exercise of the Option having a Fair Market Value on the date of
Option exercise equal to the aggregate exercise price of the Option or exercised portion thereof, in accordance with Section 6.2 of the Plan, and any applicable tax withholding shall be satisfied by the Company withholding shares of Common
Stock otherwise issuable under such Option (or allowing the return of shares of Common Stock) having a Fair Market Value equal to the statutory minimum sums required to be withheld, in accordance with Section 12.6 of the Plan. 

4.4 Conditions to Issuance of Stock Certificates. The shares of Common Stock deliverable upon the exercise of the Option, or any portion
thereof, may be either previously authorized but unissued shares or issued shares which have then been 

  
 8. 

 
reacquired by the Company. Such shares shall be fully paid and nonassessable. The Company shall not be required to issue or deliver any certificate or certificates for shares of Common Stock
purchased upon the exercise of the Option or portion thereof prior to fulfillment of all of the following conditions: 
 (a) The
admission of such shares to listing on all stock exchanges on which such Common Stock is then listed; and 
 (b) The completion
of any registration or other qualification of such shares under any state or federal law or under rulings or regulations of the Securities and Exchange Commission or of any other governmental regulatory body, which the Committee shall, in its
absolute discretion, deem necessary or advisable; and 
 (c) The obtaining of any approval or other clearance from any state or
federal governmental agency which the Committee shall, in its absolute discretion, determine to be necessary or advisable; and 

(d) The receipt by the Company of full payment for such shares, including payment of all amounts which, under federal, state or local tax
law, the Company (or other employer corporation) is required to withhold upon exercise of the Option; and 
 (e) The lapse of
such reasonable period of time following the exercise of the Option as the Committee may from time to time establish for reasons of administrative convenience. 
 4.5 Rights as Stockholder. The holder of the Option shall not be, nor have any of the rights or privileges of, a stockholder of the Company in respect of any shares purchasable upon the exercise of any
part of the Option unless and until certificates representing such shares shall have been issued by the Company to such holder. 

4.6 Change in Control. In the event of a Change in Control, the treatment of awards as set forth in Section 12.4 of the Plan shall
not apply to the Option, and instead, the following provisions shall apply: 
 (a) In the event of a Change in Control, the
surviving entity or acquiring entity (or the surviving or acquiring entity’s parent company) shall assume the Option or shall substitute similar stock options or rights for the Option; provided, however, and not withstanding
anything to the contrary herein, if within the period beginning upon the consummation of the Change in Control and ending eighteen (18) months after a Change in Control, Optionee incurs a Termination of Employment by the Company for reasons
other than for Cause, or by Optionee for Good Reason, any and all unvested Options granted hereunder will automatically accelerate and become immediately exercisable. 
 (b) Notwithstanding the foregoing, to the extent the surviving entity (or acquiring entity or parent company, as the case may be) refuses to assume the Option or to substitute an equivalent stock option
or right (as determined by the Administrator in its 

  
 9. 

 
sole discretion), immediately prior to such Change in Control the Option shall become fully vested and exercisable for all of the shares of Common Stock at the time subject to the Option and may
be exercised for any or all of those shares as fully-vested shares of Common Stock. 
 ARTICLE V 

OTHER PROVISIONS 
 5.1 Administration. The Committee shall have the power to interpret the Plan and this Agreement and to adopt such rules for the administration, interpretation and application of the Plan as are consistent
therewith and to interpret, amend or revoke any such rules. All actions taken and all interpretations and determinations made by the Committee in good faith shall be final and binding upon the Optionee, the Company and all other interested persons.
No member of the Committee shall be personally liable for any action, determination or interpretation made in good faith with respect to the Plan, this Agreement or the Option. In its absolute discretion, the Board may at any time and from time to
time exercise any and all rights and duties of the Committee under the Plan and this Agreement. 
 5.2 Option Not Transferable.

 (a) The Option may not be sold, pledged, assigned or transferred in any manner other than by will or the laws of descent and
distribution or, subject to the consent of the Committee, pursuant to a “DRO” (as defined in the Plan), unless and until the Option has been exercised, or the shares underlying such Option have been issued, and all restrictions applicable
to such shares have lapsed. Neither the Option nor any interest or right therein shall be liable for the debts, contracts or engagements of the Optionee or his or her successors in interest or shall be subject to disposition by transfer, alienation,
anticipation, pledge, encumbrance, assignment or any other means whether such disposition be voluntary or involuntary or by operation of law by judgment, levy, attachment, garnishment or any other legal or equitable proceedings (including
bankruptcy), and any attempted disposition thereof shall be null and void and of no effect, except to the extent that such disposition is permitted by the preceding sentence. 
 (b) During the lifetime of the Optionee, only the Optionee may exercise the Option (or any portion thereof), unless it has been disposed of with the consent of the Committee pursuant to a DRO. After the
death of the Optionee, any exercisable portion of an Option may, prior to the time when such portion becomes unexercisable under the Plan or the Option Agreement, be exercised by the Optionee’s personal representative or by any person empowered
to do so under the deceased Optionee’s will or under the then applicable laws of descent and distribution. 
 (c)
Notwithstanding the foregoing provisions of this Section 5.2, if designated as a Non-Qualified Stock Option, the Option may be transferred by the Optionee, in writing and with prior written notice to the Committee, to any one or more Permitted

  
 10.

 
Transferees (as defined below), subject to the following terms and conditions: (i) the Option, as transferred to a Permitted Transferee, shall not be assignable or transferable by the
Permitted Transferee other than by will or the laws of descent and distribution; (ii) the Option, as transferred to a Permitted Transferee, shall continue to be subject to all the terms and conditions of the Option as applicable to the Optionee
(other than the ability to further transfer the Option); and (iii) the Optionee and the Permitted Transferee shall execute any and all documents requested by the Committee, including, without limitation documents to (A) confirm the status
of the transferee as a Permitted Transferee, (B) satisfy any requirements for an exemption for the transfer under applicable federal and state securities laws and (C) evidence the transfer. For purposes of this subsection (c),
“Permitted Transferee” shall mean, with respect to the Optionee, any child, stepchild, grandchild, parent, stepparent, grandparent, spouse, former spouse, sibling, niece, nephew, mother-in-law, father-in-law, son-in-law, daughter-in-law,
brother-in-law, or sister-in-law, including adoptive relationships, any person sharing the Optionee’s household (other than a tenant or employee), a trust in which these persons (or the Optionee) control the management of assets, and any other
entity in which these persons (or the Optionee) own more than fifty percent (50%) of the voting interests, or any other transferee specifically approved by the Committee after taking into account any state or federal tax or securities laws
applicable to transferable Non-Qualified Stock Options. 
 5.3 Lock-Up Period. The Optionee hereby agrees that, if so requested
by the Company or any representative of the underwriters (the “Managing Underwriter”) in connection with any registration of the offering of any securities of the Company under the Securities Act, the Optionee shall not sell or otherwise
transfer any shares of Common Stock or other securities of the Company during such period as may be requested in writing by the Managing Underwriter and agreed to in writing by the Company (which period shall not be longer than 180 days) (the
“Market Standoff Period”) following the effective date of a registration statement of the Company filed under the Securities Act. 
 5.4 Restrictive Legends and Stop-Transfer Orders. 
 (a) The share certificate or
certificates evidencing the shares of Common Stock purchased hereunder shall be endorsed with any legends that may be required by state or federal securities laws. 
 (b) The Optionee agrees that, in order to ensure compliance with the restrictions referred to herein, the Company may issue appropriate “stop transfer” instructions to its transfer agent, if
any, and that, if the Company transfers its own securities, it may make appropriate notations to the same effect in its own records. 
 (c) The Company shall not be required: (i) to transfer on its books any shares of Common Stock that have been sold or otherwise transferred in violation of any of the provisions of this Agreement, or
(ii) to treat as owner of such shares of Common Stock or to accord the right to vote or pay dividends to any purchaser or other transferee to whom such shares shall have been so transferred. 

  
 11.

 5.5 Shares to Be Reserved. The Company shall at all times during the term of the Option
reserve and keep available such number of shares of Common Stock as will be sufficient to satisfy the requirements of this Agreement. 
 5.6 Notices. Any notice to be given under the terms of this Agreement to the Company shall be addressed to the Company in care of the Secretary, and any notice to be given to the Optionee shall be
addressed to the Optionee at the address given beneath the Optionee’s signature hereto. By a notice given pursuant to this Section 5.6, either party may hereafter designate a different address for notices to be given to that party. Any
notice which is required to be given to the Optionee shall, if the Optionee is then deceased, be given to the Optionee’s personal representative if such representative has previously informed the Company of such representative’s status and
address by written notice under this Section 5.6. Any notice shall be deemed duly given when enclosed in a properly sealed envelope or wrapper addressed as aforesaid, deposited (with postage prepaid) in a post office or branch post office
regularly maintained by the United States Postal Service. 
 5.7 Titles. Titles are provided herein for convenience only and are
not to serve as a basis for interpretation or construction of this Agreement. 
 5.8 Stockholder Approval. The Plan will be
submitted for approval by the Company’s stockholders within twelve (12) months after the date the Plan was initially adopted by the Board. The Option may not be exercised to any extent by anyone prior to the time when the Plan is approved
by the stockholders, and if such approval has not been obtained by the end of said twelve month period, the Option shall thereupon be canceled and become null and void. 
 5.9 Notification of Disposition. If this Option is designated as an Incentive Stock Option, the Optionee shall give prompt notice to the Company of any disposition or other transfer of any shares of stock
acquired under this Agreement if such disposition or transfer is made (a) within two (2) years from the Date of Grant with respect to such shares or (b) within one (1) year after the transfer of such shares to him. Such notice
shall specify the date of such disposition or other transfer and the amount realized, in cash, other property, assumption of indebtedness or other consideration, by the Optionee in such disposition or other transfer. 

5.10 Construction. This Agreement shall be administered, interpreted and enforced under the laws of the State of California without
regard to conflicts of laws thereof. 
 5.11 Conformity to Securities Laws. The Optionee acknowledges that the Plan is intended
to conform to the extent necessary with all provisions of the Securities Act and the Exchange Act and any and all regulations and rules promulgated by the Securities 

  
 12.

 
and Exchange Commission thereunder, and state securities laws and regulations. Notwithstanding anything herein to the contrary, the Plan shall be administered, and the Option is granted and may
be exercised, only in such a manner as to conform to such laws, rules and regulations. To the extent permitted by applicable law, the Plan and this Agreement shall be deemed amended to the extent necessary to conform to such laws, rules and
regulations. 
 5.12 Amendments. This Agreement may not be modified, amended or terminated except by an instrument in writing,
signed by the Optionee or such other person as may be permitted to exercise the Option pursuant to Section 4.1 and by a duly authorized representative of the Company. 
 5.13 Section 409A of the Code. It is intended that the terms of this Agreement will not result in the imposition of any tax liability pursuant to Section 409A of the Code. This Agreement shall
be construed and interpreted consistent with that intent. 

  
 13.

 GEN-PROBE INCORPORATED 

STOCK OPTION GRANT NOTICE 

(2003 Incentive Award Plan) 
 GEN-PROBE INCORPORATED (the “Company”), pursuant to its 2003 Incentive Award Plan (the “2003 Plan”), hereby grants to
Optionholder an option to purchase the number of shares of the Company’s Common Stock set forth below. This option is subject to all of the terms and conditions as set forth herein and in the Stock Option Agreement, the 2003 Plan and the Notice
of Exercise, all of which are attached hereto and incorporated herein in their entirety. 
  

					
	Optionholder:	  	  
	  	
	Date of Grant:	  	  
	  	
	Vesting Commencement Date:	  	  
	  	
	Number of Shares Subject to Option:	  	                            
               shares	  	
	Exercise Price Per Share:	  	$                         per share	  	
	Expiration Date:	  	  
	  	

  

					
	Type of Grant:	  	 ̈  Incentive Stock Option	  	 ̈  Nonstatutory Stock Option
			
	Exercise Schedule:	  	x  Same as Vesting Schedule	  	
		
	Vesting Schedule:	  	One fourth (1/4) of the Option Shares will vest one year after the Vesting Commencement Date. The remainder of the Option Shares will vest monthly thereafter over the
following three (3) years at a rate of 1/48th of the
shares each month.
		
	Payment:	  	 By one or a combination of the following items (described in the Stock Option Agreement):

 
 By cash or check;
 Pursuant to a Regulation T Program if the Shares are publicly traded; or
 By surrender of shares of
Common Stock then issuable upon exercise of the Option (in the case of an automatic exercise pursuant to Section 4.3(f) of the Stock Option Agreement).

 Additional Terms/Acknowledgements: The undersigned Optionholder acknowledges receipt of, and understands and
agrees to, this Grant Notice, the Stock Option Agreement and the 2003 Plan. Optionholder further acknowledges that as of the Date of Grant, this Grant Notice, the Stock Option Agreement and the 2003 Plan set forth the entire understanding between
Optionholder and the Company regarding the acquisition of stock in the Company and supersede all prior oral and written agreements on that subject with the exception of (i) options previously granted and delivered to Optionholder under the 2003
Plan, and (ii) the following agreements only: 
  

			
	OTHER AGREEMENTS:	  	x    None.
		
		  	 ̈    See Attached Sheet.

  

									
	GEN-PROBE INCORPORATED	 		 	OPTIONHOLDER
				
	By:	 	  
	 		 	  

		 	Signature	 		 		 	Signature
					
	Title:	 	  
	 		 	Date:	 	  

					
	Date:	 	  
	 		 		 	

 ATTACHMENTS: Stock Option Agreement, 2003 Incentive Award Plan and Exercise Notice

 Attachment I 
 Stock Option Agreement 

 Attachment II 
 2003 Incentive Award Plan 

 Attachment III 

Form of Exercise Notice 

Gen-Probe Incorporated 
 10210 Genetic Center
Drive 
 San Diego, California 92121-4362 
 Attention: Corporate Secretary 
  

	 	Re:	Exercise of Stock Option 

 Ladies and
Gentlemen: 
 1. Exercise of Option. The undersigned Optionee,
                    , was granted an option (the “Option”) to purchase shares of the Common Stock, par value $0.0001 per share
(“Common Stock”), of Gen-Probe Incorporated, a Delaware corporation (the “Company”), effective as of                 , pursuant to the Stock Option
Agreement, dated                  (the “Option Agreement”). The undersigned hereby elects to exercise the Option as follows: 

 

	(a)	The undersigned hereby elects to exercise the Option as to              shares of the Common Stock, in
accordance with Section 3.1 of the Option Agreement (the “Shares”). 

  

	(b)	The date of this exercise is                  ,
        . 

 2. Payment. The undersigned has enclosed herewith
                 (representing full payment for such Shares in accordance with Section 4.3 of the Option Agreement). The undersigned authorizes payroll withholding
and otherwise will make adequate provision for the tax withholding obligations of the Company, if any, with respect to such exercise. 
 3.
Binding Effect. The undersigned agrees that the Shares are being acquired in accordance with and subject to the terms, provisions and conditions of the Option Agreement set forth therein, to all of which the undersigned hereby expressly assents.
This Agreement shall inure to the benefit of and be binding upon the heirs, executors, administrators, successors and assigns of the undersigned. 
 The undersigned understands that he or she is purchasing the Shares pursuant to the terms of the Option Agreement, a copy of which the undersigned has received and carefully read and understands.

  

	
	  

  

			
	Receipt of the above is hereby acknowledged
	
	 GEN-PROBE INCORPORATED,
 a Delaware corporation

		
	By:	 	  

			
		
	Title:EX-10.5

 Exhibit 10.5 
 When recorded, return to: 
 James R. Littlejohn 

Winstead PC 
 5400 Renaissance Tower 

1201 Elm Street 
 Dallas, Texas 75270 

FIRST AMENDMENT TO DEED OF TRUST 
 THIS FIRST AMENDMENT TO DEED OF TRUST (this “First Amendment”), dated as of December 21, 2011, is entered into between POWERSECURE, INC., a Delaware corporation (the
“Grantor”), whose chief executive office and mailing address for notice hereunder is 1609 Heritage Commerce Ct., Wake Forest, North Carolina 27587, Attention: President and Chief Executive Officer, and whose organizational
identification number issued by the State of Delaware is DE 3278285, and CITIBANK, N.A., as Beneficiary for the Secured Creditors (as defined in the Credit Agreement defined below). 

BACKGROUND 
 A. PowerSecure International, Inc., a Delaware corporation (the “Borrower”), the Administrative Agent and the Lenders party thereto entered into that certain Credit Agreement, dated as of
August 23, 2007, as amended, supplemented, modified and restated (the “Original Credit Agreement”). 
 B. The Grantor executed a Deed of Trust, dated as of January 17, 2008, in favor of Mary C. Tucker (the “Trustee”) for the benefit of the Beneficiary for the Secured Creditors,
recorded in the Official Public Records of Wake County, Texas on January 18, 2008, in Book 012917, Pages 01243-01294, encumbering that certain real property described on Exhibit A attached hereto and made a part thereof
for all purposes, and all other property described therein (the “Deed of Trust”; the terms defined in the Deed of Trust or the Existing Credit Agreement (as hereinafter defined) and not otherwise defined herein shall be used herein
as defined in the Deed of Trust or the Existing Credit Agreement, as applicable). 
 C. The Borrower is amending
and restating the Original Credit Agreement by entering into an Amended and Restated Credit Agreement, dated as of December 21, 2011, among the Borrower, the lenders party thereto and Citibank, N.A., as Administrative Agent (as amended,
supplemented, modified and restated, the “Existing Credit Agreement”). 
 NOW, THEREFORE, in
consideration of the covenants, conditions and agreements hereafter set forth, and for other good and valuable consideration, the receipt and adequacy of which are all hereby acknowledged, the Grantor and the Beneficiary covenant and agree as
follows: 

  

 1. AMENDMENTS TO THE DEED OF TRUST. 

(a) The following defined terms set forth in Section 1.1 of the Deed of Trust are hereby amended to read as follows:

 Administrative Agent: As defined in the Existing Credit. 

Beneficiary: Citibank, N.A., in its capacity as Administrative Agent, for the benefit of Secured
Creditors, whose address for notice hereunder is 2001 Ross Avenue, Suite 4300, Dallas, Texas 75201, Attention: Gary D. Pitcock. 

Default Rate: The rate of interest specified in the Existing Credit Agreement as the
“Default Rate” to be paid at the times specified in the Existing Credit Agreement, but not in excess of the Highest Lawful Rate. 

Existing Credit Agreement: The Amended and Restated Credit Agreement, dated as of
December 21, 2011, among PowerSecure International, Inc., Citibank, N.A., as Administrative Agent, and the other lenders party thereto, as amended, modified, supplemented and restated from time to time. 

Law: As defined in the Existing Credit Agreement. 

Loan Document: As defined in the Existing Credit Agreement. 

Loan Party: As defined in the Existing Credit Agreement. 

Material Adverse Effect: As defined in the Existing Credit Agreement. 

Notes: As defined in the Existing Credit Agreement. 

Person: As defined in the Existing Credit Agreement. 

Secured Creditor: As defined in the Existing Credit Agreement. 

Secured Obligations: As defined in the Existing Credit Agreement. 

(b) Section 1.1 of the Deed of Trust is further amended by deleting the defined term “Term Credit
Agreement” therefrom. 
 (c) The penultimate sentence of Section 2.1 of the Deed of Trust is
hereby amended to read as follows: 
 The amount of present obligations secured is [$need outstanding amount
at closing], and the maximum principal amount including present and future obligations, which may be secured is $22,260,000. 

  
 2 

 2. REPRESENTATIONS AND WARRANTIES TRUE; NO EVENT OF DEFAULT. By its
execution and delivery hereof, the Grantor represents and warrants as to itself that, as of the date hereof and after giving effect to the amendments contemplated by the foregoing Section 1: 

(a) the representations and warranties of the Grantor contained in the Deed of Trust are true and correct on and as of
the date hereof as if made on and as of such date, except to the extent that such representations and warranties specifically refer to an earlier date, in which case they shall be true and correct as of such earlier date; 

(b) the Grantor has full power and authority to execute and deliver this First Amendment, and this First Amendment and
the Deed of Trust, as amended hereby, constitute the legal, valid and binding obligations of the Grantor, enforceable against such Debtor in accordance with their respective terms, except as enforceability may be limited by applicable Debtor Relief
Laws and by general principles of equity (regardless of whether enforcement is sought in a proceeding in equity or at law); and 
 (c) no authorization, approval, consent, or other action by, notice to, or filing with, any governmental authority or other Person not already obtained, is required for the execution, delivery or
performance by the Grantor of this First Amendment. 
 3. CONDITIONS TO EFFECTIVENESS. This First
Amendment shall be effective as of December 21, 2011, subject to the following: 
 (a) the Beneficiary
shall have executed counterparts of this First Amendment; 
 (b) the Beneficiary shall have received
counterparts of this First Amendment executed by the Grantor; 
 (c) the representations and warranties set
forth in Section 2 of this First Amendment shall be true and correct; and 
 (d) the Beneficiary shall have
received in form and substance satisfactory to the Beneficiary, such other documents and certificates as the Beneficiary shall require. 
 4. REFERENCE TO THE DEED OF TRUST. 
 (a) Upon the
effectiveness of this First Amendment, each reference in the Deed of Trust to “this Deed of Trust”, “hereunder”, or words of like import shall mean and be a reference to the Deed of Trust, as affected and amended by this First
Amendment. 
 (b) The Deed of Trust, as amended by this First Amendment, and all Liens granted thereunder shall
remain in full force and effect and are hereby ratified and confirmed, as Grantor acknowledges and agrees that the Obligations under the Original Credit Agreement are not novated or extinguished by the Existing Credit Agreement, but such Obligations
are continued, renewed and extended pursuant to the Existing Credit Agreement. 

  
 3 

 5. COSTS, EXPENSES AND TAXES. The Grantor, agrees to pay on demand
all costs and expenses of the Beneficiary in connection with the preparation, reproduction, execution and delivery of this First Amendment and the other instruments and documents to be delivered hereunder (including the reasonable fees and
out-of-pocket expenses of counsel for the Secured Party with respect thereto and with respect to advising the Beneficiary as to its rights and responsibilities under the Deed of Trust, as amended by this First Amendment). 

6. EXECUTION IN COUNTERPARTS. This First Amendment may be executed in any number of counterparts and by different
parties hereto in separate counterparts, each of which when so executed and delivered shall be deemed to be an original and all of which when taken together shall constitute but one and the same instrument. For purposes of this First Amendment, a
counterpart hereof (or signature page thereto) signed and transmitted by any Person party hereto to the Beneficiary (or its counsel) by facsimile machine, telecopier or electronic mail is to be treated as an original. The signature of such Person
thereon, for purposes hereof, is to be considered as an original signature, and the counterpart (or signature page thereto) so transmitted is to be considered to have the same binding effect as an original signature on an original document.

 7. GOVERNING LAW; BINDING EFFECT. This First Amendment shall be governed by, and construed in
accordance with the laws of the State of Texas and the applicable laws of the United States of America, and shall be binding upon all parties hereto and their respective successors and assigns. 

8. HEADINGS. Section headings in this First Amendment are included herein for convenience of reference only and
shall not constitute a part of this First Amendment for any other purpose. 
 9. ENTIRE AGREEMENT. THE
DEED OF TRUST, AS AMENDED BY THIS FIRST AMENDMENT, AND THE OTHER LOAN DOCUMENTS REPRESENT THE FINAL AGREEMENT BETWEEN THE PARTIES AS TO THE SUBJECT MATTER THEREIN, AND HEREIN AND MAY NOT BE CONTRADICTED BY EVIDENCE OF PRIOR, CONTEMPORANEOUS, OR
SUBSEQUENT ORAL AGREEMENTS BETWEEN THE PARTIES. 
 REMAINDER OF PAGE LEFT INTENTIONALLY BLANK 

  
 4 

 IN WITNESS WHEREOF, this First Amendment is executed as of the date first
set forth above. 
  

			
	GRANTOR:
	
	POWERSECURE, INC., a Delaware corporation
		
	By:	 	/s/ Christopher T. Hutter         
		 	Christopher T. Hutter
		 	Chief Financial Officer

  
 5 

  

			
	BENEFICIARY:
	
	CITIBANK, N.A.
		
	By:	 	/s/ Gary D. Pitcock         
		 	Gary D. Pitcock
		 	Vice President

  

							
	 STATE OF NORTH CARLINA
	  	§	  		  	
		  	§	  		  	
	 COUNTY OF WAKE            §
	  		  		  	

 I, Dana S. Cail, a Notary Public of Wake County, State of North Carolina, certify that
Christopher T. Hutter (the “Signatory”) personally came before me this day and acknowledged that he is Chief Financial Officer of PowerSecure, Inc., a Delaware corporation, and that he, in such capacity and being authorized to do so,
executed the foregoing on behalf of the corporation. 
 I certify that the Signatory personally appeared before
me this day and 
 (check one of the following and mark through all blank lines or spaces in the certificate) 

x (I have personal knowledge of the identity of the Signatory); or

  ̈ (I have seen satisfactory evidence of the
Signatory’s identity, by a current state or federal identification with the Signatory’s photograph in the form of: 
 (check one of the following) 
  ̈ a driver’s license or 

 ̈ in the form of
            ); or 
  ̈ (a credible witness has sworn to the identity of the Signatory). 

The Signatory acknowledged to me that he voluntarily signed the foregoing instrument for the purpose stated and in the
capacity indicated. 
 Witness my hand and official stamp or seal this 21st day of December, 2011. 

 

			
	
	
	/s/ Dana S. Cail
	Notary Public
	Print Name:                       
                                         
                
	[Note: Notary Public must sign exactly as on notary seal]
	
	My Commission Expires:
                                         
            
	
	
	E [NOTARY SEAL] (MUST BE FULLY LEGIBLE)

  
 6 

  

					
	 STATE OF TEXAS
	 	 §
	  	
		 	 §
	  	
	 COUNTY OF DALLAS
	 	 §
	  	

 The foregoing instrument was ACKNOWLEDGED before me this 21st day of December, 2011, by
Gary D. Pitcock, a Senior Vice President of Citibank, N.A., a national banking association, on behalf of said association. 
  

					
			
	[ S E A L ]	 		 	 /s/ Betty N. Gorman

			
		 		 	Notary Public, State of Texas
	My Commission Expires:	 		 	
		 		 	
                    
                             

	  
	 		 	Printed Name of Notary Public

  
 7 

 EXHIBIT “A” 

Land Description 

Name of owner of fee title to Land: PowerSecure, Inc. 

  
 8

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