Document:

Amendment to Offer Letter - Mark W. Noel

 Exhibit 10.4 
 [Curis Letterhead] 
 October 27, 2008 
 Mark W. Noel 
 Curis, Inc. 
 45
Moulton St. 
 Cambridge, Massachusetts 02138 
  

	Re:	Amended Offer Letter 

 Dear Mark: 
 Reference is hereby made to the Offer Letter Agreement, dated January 11, 2001, by and between Curis, Inc. (“Curis”) and you (the “Offer
Letter”) as amended by the Amendment to Offer Letter, dated as of October 31, 2006, by and between Curis and you (the “Amendment”, and, together with the Offer Letter, the “Amended Offer Letter”). 
 Notwithstanding anything to the contrary in the Amended Offer Letter, Curis and you hereby agree that, as of the date hereof, in consideration for the grant to you of an
option to purchase 43,000 shares of common stock of Curis (the “Option”), your base salary shall be reduced from $210,000 to $189,000 per annum, and shall remain subject to review as part of our performance review program. The Option will
be granted pursuant to our 2000 Stock Incentive Plan (the “Plan”) and will be subject to the terms and conditions of the Plan and a stock option agreement by and between you and the Company in the form previously furnished to you.

 Curis and you hereby agree that the aforementioned reduction in salary shall not constitute “Good Reason” as defined in the Amended Offer Letter
and that in connection with any termination of employment you hereby waive any claim for benefits under said agreement as a result of such reduction. 
 In
addition, Curis and you hereby agree to further amend the Amended Offer Letter as follows: 
  

	1.	Sections 1.2(b) and 1.2(e) of the Amended Offer Letter are hereby amended by deleting the following clause from such sections: 

 “upon execution by the Executive of a general release of all claims against the Company, its employees, officers, directors and agents, in a form drafted by the
Company,” 
  

	2.	Sections 1.2(b)(ii) and 1.2(e)(ii) of the Amended Offer Letter are hereby amended by deleting such sections in their entirety and substituting for each the following:

 “(ii) receive payments equal to one-half (1/2) of the greater of (x) the Executive’s base salary in effect on
September 30, 2008 or (y) the Executive’s then base salary, reduced by all applicable taxes and withholdings, over a period of six months in accordance with the Company’s then current payroll policies and practices and”

  

	3.	The penultimate sentence of Section 1.2(e) of the Amended Offer Letter is hereby amended by deleting such sentence in its entirety and substituting therefore the following:

 “For purposes of this paragraph, the Executive’s “base salary” shall be the greater of the amount in effect (x) on
September 30, 2008, (y) immediately prior to the Change in Control Event or (z) on the termination date of Executive’s employment.” 

	4.	Section 1.2(g) of the Amended Offer Letter is hereby amended by deleting such section in its entirety and substituting therefore the following: 

 “Notwithstanding any provision of this Amendment to the contrary, if, at the time the Executive’s employment is terminated, the Executive is a “specified
employee” within the meaning of Section 409A(a)(2)(B)(ii) of the Internal Revenue Code and the regulations thereunder, as determined by the Company in accordance with its procedures, by which determination the Executive hereby agrees that
he is bound, then any payments to be paid or provided to the Executive under this Amendment that constitute “nonqualified deferred compensation” within the meaning of Section 409A of the Code shall be delayed by a period of six
(6) months and all payments that would have been made to the Executive during such six (6) month period shall be made in a lump sum in the seventh (7th) month following the date of termination.” 
  

	5.	The following new Subsection 1.2(h) hereby is added to the Amended Offer Letter: 

 “The receipt of any severance benefits provided for under the Offer Letter as amended by this Amendment or otherwise shall be dependent upon the Executive’s delivery to the Company of an effective general release of claims in a
form satisfactory to the Company within 60 days of the date of the Executive’s termination of employment, and shall be paid or commence no later than thirty (30) days thereafter; provided, however, that if the date on which the severance
benefits are to be paid or commence occurs in the calendar year following the year of the Executive’s date of termination, the severance payments shall be paid or commence no earlier than January 1 of such subsequent calendar year.
Notwithstanding the foregoing, any payment of benefits under this subparagraph shall be subject to the provisions of Subsection 1.2(g) to the extent applicable.” 
  

			
	 Very truly yours,
  
 CURIS, INC.

		
	By:	 	/s/ Michael P. Gray
	Name:	 	Michael P. Gray
	Title:	 	Chief Financial Officer and Chief Operating Officer

  
  
 Agreed and accepted as of the date first written above: 
  

			
		
	By:	 	/s/ Mark W. Noel
		 	Mark W. NoelAmendment No.3, dated as of July 23, 2008, to Collaboration Agreement

 EXHIBIT 10.4 
 VIA FACSIMILE AND 
 OVERNIGHT MAIL 
 Michael R. Dougherty 
 President and Chief Executive Officer 
 Adolor Corporation 
 700 Pennsylvania Drive 
 Exton,
Pennsylvania 19341 
  

	Re:    Amendment	No. 3 to Collaboration Agreement 

 Dear Mike,

 This letter amendment (“Amendment No. 3”), effective as of June 9, 2008, is in reference to the Collaboration Agreement dated
April 14, 2002 (the “Collaboration Agreement”), as amended by Amendment No. 1 to the Collaboration Agreement effective on June 24, 2003 (“Amendment No. 1”) and Amendment No. 2 to the Collaboration
Agreement effective on December 22, 2004 (“Amendment No. 2”) (the Collaboration Agreement, Amendment No. 1 and Amendment No.2 are collectively referred to herein as, the “Agreement”), by and between Adolor
Corporation (“Adolor”) and Glaxo Group Limited (“GGL”). All capitalized terms used in this Amendment No. 3 that are not otherwise defined herein shall have the meanings given to them in the Agreement. 
 Notwithstanding anything to the contrary in the Agreement, the terms pursuant to which GSK shall deploy and pay incentive compensation to the GSK Sales Representatives
during the period beginning on the date of the First Commercial Sale of the POI Product in the United States until December 31, 2008 (the “Launch Period”) shall be as follows: 
 Subject to an annual [**] percent [**] vacancy rate, GSK shall deploy not less than [**] GSK Sales Representatives to Detail the POI Product to the Target Audience in
the United States during the Launch Period. The Parties acknowledge and agree that a GSK Sales Representative shall mean and include those individuals referred to internally by GSK in the United States as “Account Managers” who are
hospital based. This deployment of GSK Sales Representatives as set forth in this Amendment No. 3 shall be considered as the Sales Representative FTE Requirements for GSK during the Launch Period. Further, during the Launch Period, GSK will not
categorize the GSK Sales Representatives as Hospital Account Managers, Oncology Account Managers or Surgical Account Managers. 
  

	 	1.	The incentive compensation available to be earned by a GSK Sales Representative with respect to the POI Product during the Launch Period will be [**] the GSK Sales
Representative’s base incentive compensation (defined below). The incentive compensation available to be earned by GSK Sales Representatives during the Launch Period with respect to the POI Product shall be as set forth on Exhibit A attached
hereto and incorporated herein, and shall be at average target, not less than [**] of the total target incentive compensation available to be earned by such GSK Sales Representatives during the Launch Period The term “total target incentive
compensation” as used above means the incentive compensation available to be earned at [**] quota attainment for all products, including the POI Product, promoted by a GSK Sales Representative during the Launch Period. 

This Amendment No. 3 shall remain in effect until December 31, 2008. Prior to December 1, 2008, Adolor and GSK will negotiate in good faith and
finalize any amendments to the Agreement with respect to the 
 [**] Certain information on this page has been omitted and filed separately with the
Commission. Confidential treatment has been requested with respect to the omitted portions. 

 Michael R. Dougherty 
 Page 2

 terms pursuant to which the Parties will deploy and pay Incentive Compensation to the Sales Representatives for the remainder of Year 1, and Years 2 and 3
following First Commercial Sale of the POI Product. In the event that the Parties are unable to reach agreement on the terms pursuant to which the Parties will deploy and pay Incentive Compensation to the Sales Representatives for the remainder of
Year 1, and Years 2, and 3 following First Commercial Sale of the POI Product, the Parties shall comply with the provisions set forth in the Collaboration Agreement, as amended prior to this Amendment No. 3. 
 This Amendment No. 3 shall be construed, and the respective rights of the Parties determined, according to the substantive law of the State of Delaware
notwithstanding the provisions governing conflict of laws under such Delaware law to the contrary. Except as set forth in this Amendment No. 3, the Agreement shall remain in full force and effect and is hereby ratified and confirmed except that
each reference to the “Agreement” or words of like import in the Agreement will mean and be a reference to the Agreement as amended by this Amendment No. 3. 
 Please sign two copies of this Amendment No. 3 where indicated below to confirm Adolor’s agreement to this Amendment No. 3 and return one copy to the attention of Hope D’Oyley-Gay, Assistant
General Counsel, GlaxoSmithKline, 2301 Renaissance Boulevard, King of Prussia, PA 19406. This Amendment No. 3 may be executed in any two counterparts, each of which, when executed, shall be deemed to be an original and both of which together
shall constitute one and the same document. Further, this Amendment No. 3 may be executed by facsimile signatures, which signatures shall have the same force and effect as original signatures. 
 Very truly yours, 
 GLAXO GROUP LIMITED 
  

			
	By:	 	 /s/    Carol G. Ashe

	Name:	 	Carol G. Ashe
	Title:	 	Attorney-in Fact

 Acknowledged and Agreed 
 ADOLOR CORPORATION 
  

			
	By:	 	 /s/    Michael R. Dougherty

	Name:	 	Michael R. Dougherty
	Title:	 	President and Chief Executive Officer

  

	cc:	Martha Manning, Esq. 

 Randall B. Sunberg, Esq. 

Anne Whitaker 
 Sheri Mullen 
 Kevin LaWall 
 Hope D’Oyley-Gay, Esq.

 Vinod Ramachandran 

 Michael R. Dougherty 
 Page 3

 EXHIBIT A 
 [**]

 [**] Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to
the omitted portions.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00148-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00148-of-00352.parquet"}]]