Document:

EXHIBIT 10.5

THE REGISTERED HOLDER OF THIS WARRANT, BY ITS ACCEPTANCE HEREOF,  AGREES THAT IT
WILL NOT SELL, TRANSFER OR ASSIGN THIS WARRANT EXCEPT AS HEREIN PROVIDED.

                 VOID AFTER 5:00 P.M. EASTERN TIME, ____, 2009

                                    WARRANT

                              FOR THE PURCHASE OF

                          _____ SHARES OF COMMON STOCK

                                       OF

                             PHARMAFRONTIERS CORP.

1. WARRANT.

         THIS  CERTIFIES  THAT, in  consideration  of $100.00 and other good and
valuable  consideration,  duly  paid by or on  behalf  of _____  ("Holder"),  as
registered owner of this Warrant,  to PharmaFrontiers  Corp, a Texas corporation
("Company"),  Holder is  entitled,  at any time or from time to time on or after
the effective date of the Company's reverse stock split at the rate of one share
for 10 outstanding shares ("Reverse Split"), as described in Section 7.9 of that
series of  investor  agreements  in the private  offering to which this  Warrant
relates  ("Commencement  Date"),  and at or before 5:00 p.m., Eastern Time April
___, 2009,  ("Expiration Date"), but not thereafter,  to subscribe for, purchase
and receive,  in whole or in part, up to ______  (__,000) shares of Common Stock
of the Company,  $.05 par value  ("Common  Stock"),  such shares of Common Stock
subject to  adjustment  upon the  effective  date of the Reverse  Split.  If the
Expiration Date is a day on which banking  institutions are authorized by law to
close,  then this Warrant may be exercised on the next  succeeding  day which is
not such a day in accordance with the terms herein.  During the period ending on
the  Expiration  Date,  the  Company  agrees not to take any  action  that would
terminate the Warrant.  This Warrant is initially exercisable at $0.50 per share
of Common Stock purchased; provided, however, that upon the occurrence of any of
the events  specified  in Section 6 hereof,  including  the Reverse  Split,  the
rights  granted by this Warrant,  including the exercise price and the number of
shares of Common Stock to be received upon such  exercise,  shall be adjusted as
therein  specified.  The term "Exercise  Price" shall mean the initial  exercise
price or the adjusted  exercise price,  depending on the context,  of a share of
Common  Stock.  The term  "Securities"  shall  mean the  shares of Common  Stock
issuable upon exercise of this Warrant.

<PAGE>

2. EXERCISE.

         2.1 EXERCISE FORM. In order to exercise this Warrant, the exercise form
attached  hereto  must be duly  executed  and  completed  and  delivered  to the
Company,  together  with this Warrant and payment of the Exercise  Price for the
Securities being purchased.  If the subscription rights represented hereby shall
not be exercised at or before 5:00 p.m.,  Eastern time, on the Expiration  Date,
this Warrant shall become and be void without  further force or effect,  and all
rights represented hereby shall cease and expire.

         2.2 NOT  SUBJECT TO CALL.  This  Warrant is not subject to any right of
the Company to call the Warrant for  redemption  at any time.  2.3 LEGEND.  Each
certificate  for Securities  purchased under this Warrant shall bear a legend as
follows, unless such Securities have been registered under the Securities Act of
1933, as amended ("Act"):

         "The  securities   represented  by  this   certificate  have  not  been
         registered  under the  Securities  Act of 1933,  as amended  ("Act") or
         applicable  state law. The securities may not be offered for sale, sold
         or otherwise  transferred except pursuant to an effective  registration
         statement under the Act, or pursuant to an exemption from  registration
         under the Act and applicable state law."

         2.4 CONVERSION RIGHT.

                  2.4.1  DETERMINATION OF AMOUNT.  In lieu of the payment of the
Exercise Price in cash, the Holder shall have the right (but not the obligation)
to convert this  Warrant,  in whole or in part,  into Common Stock  ("Conversion
Right"),  as follows:  upon exercise of the Conversion  Right, the Company shall
deliver to the  Holder  (without  payment  by the Holder of any of the  Exercise
Price) that number of shares of Common Stock equal to the  quotient  obtained by
dividing (x) the "Value" (as defined  below) of the portion of the Warrant being
converted at the time the Conversion Right is exercised by (y) the Market Price.
The  "Value" of the  portion of the  Warrant  being  converted  shall  equal the
remainder  derived from  subtracting  (a) the Exercise  Price  multiplied by the
number of shares of Common  Stock being  converted  from (b) the Market Price of
the  Common  Stock  multiplied  by the  number of shares of Common  Stock  being
converted.  As used herein,  the term "Market Price" at any date shall be deemed
to be the last reported sale price of the Common Stock on such date, or, in case
no such  reported sale takes place on such day, the average of the last reported
sale prices for the immediately  preceding three trading days, in either case as
officially  reported by the  principal  securities  exchange on which the Common
Stock is listed or admitted to trading, or, if the Common Stock is not listed or
admitted to trading on any national  securities exchange or if any such exchange
on which the Common Stock is listed is not its  principal  trading  market,  the
last reported sale price as furnished by the National  Association of Securities
Dealers,  Inc.  ("NASD") through the Nasdaq Stock Market or, if applicable,  the
OTC Bulletin  Board, or if the Common Stock is not listed or admitted to trading
on any of the foregoing markets, or similar organization,  as determined in good
faith by resolution of the Board of Directors of the Company,  based on the best
information  available to it.

                  2.4.2 EXERCISE OF CONVERSION  RIGHT.  The Conversion Right may
be exercised by the Holder on any business day on or after the Commencement Date
and not later than the  Expiration  Date by  delivering  the Warrant with a duly
executed exercise form attached hereto with the conversion  section completed to
the Company,  exercising the Conversion Right and specifying the total number of
shares of Common Stock the Holder will purchase pursuant to such conversion.

                                       -2-
<PAGE>

3. TRANSFER.

         3.1 GENERAL RESTRICTIONS. The registered Holder of this Warrant, by its
acceptance  hereof,  agrees  that  it will  not  sell,  transfer  or  assign  or
hypothecate  this Warrant to anyone except upon compliance  with, or pursuant to
exemptions  from,  applicable  securities  laws.  In order to make any permitted
assignment,  the Holder must deliver to the Company the assignment form attached
hereto duly  executed and  completed,  together with this Warrant and payment of
all transfer taxes, if any, payable in connection  therewith.  The Company shall
immediately  transfer this Warrant on the books of the Company and shall execute
and  deliver  a new  Warrant  or  Warrants  of  like  tenor  to the  appropriate
assignee(s)  expressly  evidencing the right to purchase the aggregate number of
shares of Common Stock  purchasable  hereunder or such portion of such number as
shall be contemplated by any such assignment.

         3.2  RESTRICTIONS  IMPOSED BY THE SECURITIES  ACT. This Warrant and the
Securities underlying this Warrant shall not be transferred unless and until (i)
the  Company  has  received  the  opinion  of counsel  for the Holder  that such
securities may be sold pursuant to an exemption from registration under the Act,
and  applicable  state law,  the  availability  of which is  established  to the
reasonable  satisfaction  of  the  Company,  or  (ii) a  registration  statement
relating to such Securities has been filed by the Company and declared effective
by the Securities and Exchange  Commission and compliance with applicable  state
law.

4. NEW WARRANTS TO BE ISSUED.

         4.1  PARTIAL  EXERCISE  OR  TRANSFER.  Subject to the  restrictions  in
Section 3 hereof, this Warrant may be exercised or assigned in whole or in part.
In the event of the exercise or assignment  hereof in part only,  upon surrender
of this Warrant for  cancellation,  together with the duly executed  exercise or
assignment  form and  funds (or  conversion  equivalent)  sufficient  to pay any
Exercise  Price and/or  transfer tax, the Company shall cause to be delivered to
the Holder  without  charge a new  Warrant of like tenor to this  Warrant in the
name of the Holder  evidencing the right of the Holder to purchase the aggregate
number of shares of Common Stock and Warrants purchasable  hereunder as to which
this  Warrant has not been  exercised or assigned.

         4.2  LOST  CERTIFICATE.   Upon  receipt  by  the  Company  of  evidence
satisfactory to it of the loss, theft, destruction or mutilation of this Warrant
and of reasonably  satisfactory  indemnification,  the Company shall execute and
deliver a new Warrant of like tenor and date. Any such new Warrant  executed and
delivered  as a result of such loss,  theft,  mutilation  or  destruction  shall
constitute a substitute contractual obligation on the part of the Company.

                                      -3-
<PAGE>

5. REGISTRATION RIGHTS.

         5.1 SEPARATE  REGISTRATION  RIGHTS AGREEMENT.  The Holder will have the
registration  rights as set forth in the separate  Registration Rights Agreement
provided to the investors in the private placement to which this Warrant relates
in respect of the Securities underlying this Warrant. Such agreement,  with such
modifications  as would be  logical  to  provide  the  Holder  equal  rights  to
registration  as enjoyed by the investors,  is hereby  incorporated by reference
herein.  Notwithstanding the foregoing,  the Holder will not have the benefit of
any liquidated damage provisions that accrue to the investors.

6. ADJUSTMENTS.

         6.1  ADJUSTMENTS  TO  EXERCISE  PRICE  AND  NUMBER OF  SECURITIES.  The
Exercise Price and the number of shares of Common Stock  underlying this Warrant
shall be subject to adjustment from time to time as hereinafter set forth:

                  6.1.1 STOCK  DIVIDENDS -  RECAPITALIZATION,  RECLASSIFICATION,
SPLIT-UPS.  If, after the date hereof,  and subject to the provisions of Section
6.2 below,  the number of  outstanding  shares of Common Stock is increased by a
stock  dividend on the Common  Stock  payable in shares of Common  Stock or by a
split-up,  recapitalization  or  reclassification  of shares of Common  Stock or
other similar event,  then, on the effective date thereof,  the number of shares
of Common  Stock  issuable on exercise of this  Warrant  shall be  increased  in
proportion to such increase in outstanding shares.

                  6.1.2  AGGREGATION  OF SHARES.  If after the date hereof,  and
subject to the  provisions of Section 6.2, the number of  outstanding  shares of
Common Stock is decreased by a consolidation, combination or reclassification of
shares of Common Stock or other similar  event,  then,  upon the effective  date
thereof,  the number of shares of Common  Stock  issuable  on  exercise  of this
Warrant shall be decreased in proportion to such decrease in outstanding shares.

                  6.1.3  ADJUSTMENTS IN EXERCISE  PRICE.  Whenever the number of
shares  of  Common  Stock  purchasable  upon the  exercise  of this  Warrant  is
adjusted,  as provided in this Section 6.1, the Exercise Price shall be adjusted
(to the nearest cent) by multiplying  such Exercise Price  immediately  prior to
such  adjustment by a fraction (x) the numerator of which shall be the number of
shares of Common Stock purchasable upon the exercise of this Warrant immediately
prior to such  adjustment,  and (y) the denominator of which shall be the number
of shares of Common Stock so purchasable immediately thereafter.

                  6.1.4 REORGANIZATION,  ETC. In case of any reclassification or
reorganization  of the  outstanding  shares of Common  Stock other than a change
covered by Section 6.1.1 or Section 6.1.2 hereof or which solely affects the par
value  of  such  shares  of  Common  Stock,  or in the  case  of any  merger  or
consolidation  of the Company  with or into  another  corporation  (other than a
consolidation  or merger in which the Company is the continuing  corporation and
which  does  not  result  in  any  reclassification  or  reorganization  of  the
outstanding shares of Common Stock), or in the case of any sale or conveyance to
another  corporation  or entity of the property of the Company as an entirety or
substantially  as an entirety in connection with which the Company is dissolved,
the Holder of this Warrant shall have the right thereafter (until the expiration
of the right of exercise of this  Warrant) to receive upon the exercise  hereof,
for the same aggregate  Exercise Price payable  hereunder  immediately  prior to
such  event,  the kind and  amount  of shares  of stock or other  securities  or
property (including cash) receivable upon such reclassification, reorganization,
merger or consolidation,  or upon a dissolution following any such sale or other
transfer,  by a Holder of the  number of shares of Common  Stock of the  Company
obtainable upon exercise of this Warrant immediately prior to such event; and if
any reclassification  also results in a change in shares of Common Stock covered
by  Sections  6.1.1 or 6.1.2,  then such  adjustment  shall be made  pursuant to
Sections  6.1.1,  6.1.2,  6.1.3 and this Section  6.1.4.  The provisions of this
Section   6.1.4  shall   similarly   apply  to   successive   reclassifications,
reorganizations,  mergers or  consolidations,  sales or other  transfers.  6.1.5
CHANGES IN FORM OF WARRANT.  This form of Warrant need not be changed because of
any change  pursuant to this Section,  and Warrants issued after such change may
state the same Exercise  Price and the same number of shares of Common Stock and
Warrants  as are  stated  in the  Warrants  initially  issued  pursuant  to this
Agreement.  The  acceptance  by any  Holder  of  the  issuance  of new  Warrants
reflecting  a required  or  permissive  change  shall not be deemed to waive any
rights to a prior adjustment or the computation thereof.

                                      -4-
<PAGE>

         6.2  ELIMINATION  OF  FRACTIONAL  INTERESTS.  The Company  shall not be
required to issue certificates  representing fractions of shares of Common Stock
upon the  exercise of this  Warrant,  nor shall it be required to issue scrip or
pay cash in lieu of any fractional interests, it being the intent of the parties
that all fractional interests shall be eliminated by rounding any fraction up to
the  nearest  whole  number  of  shares  of  Common  Stock or other  securities,
properties or rights.

7.  RESERVATION  AND LISTING.  The Company  shall at all times after the Reverse
Split keep  available out of its authorized  shares of Common Stock,  solely for
the purpose of issuance upon exercise of this Warrant,  such number of shares of
Common Stock or other securities, properties or rights as shall be issuable upon
the exercise  thereof.  The Company  covenants and agrees that, upon exercise of
the Warrants and payment of the Exercise  Price  therefor,  all shares of Common
Stock and other securities issuable upon such exercise shall be duly and validly
issued,  fully paid and  non-assessable  and not subject to preemptive rights of
any stockholder. As long as the Warrants shall be outstanding, the Company shall
use its best efforts to cause all shares of Common Stock  issuable upon exercise
of the  Warrants to be listed  (subject to official  notice of  issuance) on all
securities  exchanges (or, if applicable on Nasdaq) on which the Common Stock is
then listed and/or quoted.

8. CERTAIN NOTICE REQUIREMENTS.

         8.1 HOLDER'S RIGHT TO RECEIVE NOTICE. Nothing herein shall be construed
as conferring upon the Holders the right to vote or consent or to receive notice
as a stockholder for the election of directors or any other matter, or as having
any rights whatsoever as a stockholder of the Company.  If, however, at any time
prior to the  expiration of the Warrants and their  exercise,  any of the events
described in Section 8.2 shall occur,  then, in one or more of said events,  the
Company shall give written notice of such event at least ten business days prior
to the date fixed as a record date or the date of closing the transfer books for
the determination of the stockholders  entitled to such dividend,  distribution,
conversion or exchange of securities or subscription rights, or entitled to vote
on such proposed dissolution, liquidation, winding up or sale. Such notice shall
specify  such record date or the date of the closing of the transfer  books,  as
the case may be.

                                      -5-
<PAGE>

8.2 EVENTS REQUIRING  NOTICE.  The Company shall be required to
give the notice  described in this  Section 8 upon one or more of the  following
events:  (i) if the Company  shall take a record of the holders of its shares of
Common  Stock  for the  purpose  of  entitling  them to  receive a  dividend  or
distribution,  or (ii) the Company  shall offer to all the holders of its Common
Stock any  additional  shares of  capital  stock of the  Company  or  securities
convertible into or exchangeable for shares of capital stock of the Company,  or
any  option,  right or  warrant  to  subscribe  therefor,  or (iii) a merger  or
reorganization  in which  the  Company  is not the  surviving  party,  or (iv) a
dissolution,  liquidation or winding up of the Company (other than in connection
with a  consolidation  or merger) or a sale of all or  substantially  all of its
property,  assets  and  business  shall be  proposed.

         8.3 NOTICE OF CHANGE IN EXERCISE  PRICE.  The Company  shall,  promptly
after an event  requiring a change in the Exercise  Price  pursuant to Section 6
hereof,  send notice to the Holders of such event and change  ("Price  Notice").
The Price Notice shall  describe the event  causing the change and the method of
calculating  same and  shall be  certified  as being  true and  accurate  by the
Company's  President and Chief Financial  Officer.

         8.4 TRANSMITTAL OF NOTICES. All notices,  requests,  consents and other
communications  under this  Warrant  shall be in writing  and shall be deemed to
have  been  duly  made on the  date of  delivery  if  delivered  personally,  by
facsimile or sent by overnight  courier,  with  acknowledgment of receipt by the
party to which notice is given,  or on the fifth day after  mailing if mailed to
the party to whom notice is to be given, by registered or certified mail, return
receipt requested,  postage prepaid and properly addressed as follows: (i) if to
the registered Holder of this Warrant, to the address of such Holder as shown on
the books of the Company,  or (ii) if to the Company, to its principal executive
office.

9. MISCELLANEOUS.

         9.1 HEADINGS. The headings contained herein are for the sole purpose of
convenience  of reference,  and shall not in any way limit or affect the meaning
or interpretation of any of the terms or provisions of this Warrant.

         9.2 ENTIRE AGREEMENT.  This Warrant (together with the other agreements
and documents  being  delivered  pursuant to or in connection with this Warrant)
constitutes  the entire  agreement  of the parties  hereto  with  respect to the
subject matter hereof, and supersedes all prior agreements and understandings of
the parties, oral and written, with respect to the subject matter hereof.

         9.3 BINDING  EFFECT.  This Warrant shall inure solely to the benefit of
and shall be  binding  upon,  the Holder and the  Company  and their  respective
successors, legal representatives and assigns, and no other person shall have or
be construed to have any legal or equitable  right,  remedy or claim under or in
respect of or by virtue of this Warrant or any provisions herein contained.

                                      -6-
<PAGE>

         9.4 GOVERNING LAW;  SUBMISSION TO  JURISDICTION.  This Warrant shall be
governed by and construed  and enforced in accordance  with the law of the State
of  California,  without  giving effect to conflict of laws.  The Company hereby
agrees  that any  action,  proceeding  or claim  against it  arising  out of, or
relating in any way to this Warrant  shall be brought and enforced in the courts
of the State of  California  or of the United  States of America  located in the
County  of  San  Francisco,   California,   and  irrevocably   submits  to  such
jurisdiction,  which jurisdiction shall be exclusive.  The Company hereby waives
any objection to such exclusive  jurisdiction  and that such courts represent an
inconvenient  forum. Any process or summons to be served upon the Company may be
served by  transmitting a copy thereof by registered or certified  mail,  return
receipt requested,  postage prepaid, addressed to it at the address set forth in
Section 8 hereof.  Such mailing  shall be deemed  personal  service and shall be
legal and  binding  upon the  Company in any action,  proceeding  or claim.  The
Company  agrees  that the  prevailing  party(ies)  in any such  action  shall be
entitled to recover from the other  party(ies) all of its reasonable  attorneys'
fees and  expenses  relating to such  action or  proceeding  and/or  incurred in
connection with the preparation therefor.

         9.5  WAIVER,  ETC.  The  failure of the Company or the Holder to at any
time  enforce  any of the  provisions  of this  Warrant  shall  not be deemed or
construed  to be a waiver of any such  provision,  nor to in any way  affect the
validity of this Warrant or any provision  hereof or the right of the Company or
any Holder to thereafter  enforce each and every  provision of this Warrant.  No
waiver of any breach, non-compliance or non-fulfillment of any of the provisions
of this  Warrant  shall be  effective  unless set forth in a written  instrument
executed  by the party or  parties  against  whom or which  enforcement  of such
waiver  is  sought;  and  no  waiver  of  any  such  breach,  non-compliance  or
non-fulfillment  shall be  construed  or  deemed  to be a waiver of any other or
subsequent breach, non-compliance or non-fulfillment.

         IN WITNESS WHEREOF, the Company has caused this Warrant to be signed by
its duly authorized officer as of the _____ day of April, 2006.

                         By:   /s/ David McWilliams
                         --------------------------------------------------
                               Name:  David McWilliams
                               Title: President and Chief Executive Officer

                                      -7-
<PAGE>

Form to be used to exercise Warrant:

===================================
-----------------------------------

Date:  _____________________, 20___

                  The  undersigned  hereby  elects  irrevocably  to exercise the
within   Warrant  and  to   purchase   ________   shares  of  Common   Stock  of
______________________ and hereby makes payment of $____________ (at the rate of
$_________  per share of Common Stock) in payment of the Exercise Price pursuant
thereto.  Please issue the Common Stock as to which this Warrant is exercised in
accordance with the instructions given below.

                                       OR

                  The undersigned hereby elects irrevocably to convert its right
to purchase  ____________  shares of Common Stock  purchasable  under the within
Warrant into __________ shares of Common Stock of  _____________________  (based
on a "Market  Price" of $________ per share of Common  Stock).  Please issue the
Common Stock in accordance with the instructions given below.

                                                     ---------------------------
                                                     Signature

---------------------------
Signature Guaranteed

                  NOTICE:  THE SIGNATURE TO THIS FORM MUST  CORRESPOND  WITH THE
NAME AS WRITTEN UPON THE FACE OF THE WITHIN WARRANT IN EVERY PARTICULAR  WITHOUT
ALTERATION OR ENLARGEMENT OR ANY CHANGE WHATSOEVER,  AND MUST BE GUARANTEED BY A
BANK,  OTHER THAN A SAVINGS  BANK,  OR BY A TRUST  COMPANY  OR BY A FIRM  HAVING
MEMBERSHIP ON A REGISTERED NATIONAL SECURITIES EXCHANGE.

                   INSTRUCTIONS FOR REGISTRATION OF SECURITIES

Name ________________________________________________________
                            (Print in Block Letters)

Address  ____________________________________________________

                                      -8-
<PAGE>

Form to be used to assign Warrant:

                                   ASSIGNMENT

                  (To be executed by the registered  Holder to effect a transfer
of the within Warrant):

                  FOR  VALUE  RECEIVED,   ________________________________  does
hereby sell,  assign and  transfer  unto  _________________________________  the
right   to   purchase   _____________________   shares   of   Common   Stock  of
_______________________  ("Company")  evidenced  by the within  Warrant and does
hereby authorize the Company to transfer such right on the books of the Company.

Dated:   ____________________, 20____

                                                     ---------------------------
                                                     Signature

                  NOTICE:  THE SIGNATURE TO THIS FORM MUST  CORRESPOND  WITH THE
NAME AS WRITTEN UPON THE FACE OF THE WITHIN WARRANT IN EVERY PARTICULAR  WITHOUT
ALTERATION OR ENLARGEMENT OR 8ANY CHANGE WHATSOEVER, AND MUST BE GUARANTEED BY A
BANK,  OTHER THAN A SAVINGS  BANK,  OR BY A TRUST  COMPANY  OR BY A FIRM  HAVING
MEMBERSHIP ON A REGISTERED NATIONAL SECURITIES EXCHANGE.

                                      -9-
sExhibit 10.19
                                  -------------

                SECOND AMEMDMENT TO REGISTRATION RIGHTS AGREEMENT

     This Second Amendment to Registration Rights Agreement (the "Second
Amendment") is dated as of March 31, 2006 by and among Intraop Medical
Corporation, a Nevada corporation (the "Company") and the Purchasers named below
(each, a "Purchaser" and together, the "Purchasers").

     WHEREAS, the Company and certain of the Purchasers entered into a
Registration Rights Agreement dated as of August 31, 2005 (the "August Rights
Agreement").

     WHEREAS, the Company and certain of the Purchasers entered into
Registration Rights Agreement dated as of October 25, 2005, on substantially the
same terms as the August Rights Agreement (the "October Rights Agreement" and
together with the August Rights Agreement, the "Rights Agreements").

     WHEREAS, the Company and the Purchasers entered into an Amendment to
Registration Rights Agreement dated as of January 25, 2005 to modify the
registration obligations of the Company under the Rights Agreements (the "First
Amendment").

     WHEREAS, the Company and the Purchasers have agreed to further modify the
registration obligations of the Company under the Rights Agreements, as set
forth below.

     NOW, THEREFORE, BE IT RESOLVED, for good and valuable consideration and
intending to be legally bound, the parties hereto agree as follows:

     1.   Defined Terms. Capitalized terms used and not otherwise defined herein
that are defined in the Rights Agreements shall have the meanings given such
terms in the Rights Agreements.

     2.   Amendment to Section 1 (Definitions) - Definition of Effectiveness
Date. The definition of "Effectiveness Date" set forth in Section 1 of the
Rights Agreements is hereby amended in its entirety to provide as follows:

          "Effectiveness Date" means, (i) with respect to the initial
     Registration Statement required to be filed hereunder, May 15, 2006, (ii)
     with respect to any subsequent Registration Statement referred to in
     Section 2(a), as amended, thirty (30) calendar days following the Filing
     Date for such subsequent Registration Statement and (iii) with respect to
     any additional Registration Statements which may be required pursuant to
     Section 3(c), the 120th calendar day following the date on which the
     Company first knows, or reasonably should have known, that such additional
     Registration Statement is required hereunder; provided, however, in the
     event the Company is notified by the Commission that one of the above

                                       1

<PAGE>

     Registration Statements will not be reviewed or is no longer subject to
     further review and comments, the Effectiveness Date as to such Registration
     Statement shall be the fifth Trading Day following the date on which the
     Company is so notified if such date precedes the dates required above."

     3.   Penalties; Events of Default.

     (a)  The Purchasers hereby agree that any liquidated damages or penalty
interest payable by the Company pursuant to Section 2(b)(i) of the Rights
Agreements (without giving effect to this Amendment) with respect to filing a
Registration Statement on or prior to the Filing Date are hereby waived and
extinguished.

     (b)  The Company and Purchasers party to the August Rights Agreement hereby
agree that liquidated damages payable by the Company pursuant to Section
2(b)(iv) of the August Rights Agreement with respect to the Registration
Statement not being declared effective by the Commission by its Effectiveness
Date, shall accrue commencing May 15, 2006 and shall be payable by the Company
in accordance with Section 2(b) of the August Rights Agreement.

     (c)  The Company and Purchasers party to the October Rights Agreement
hereby agree that, notwithstanding the definition of "Effectiveness Date," as
amended, liquidated damages payable by the Company pursuant to Section 2(b)(iv)
of the October Rights Agreement with respect to the Registration Statement not
being declared effective by the Commission by its Effectiveness Date, shall
accrue and be payable commencing May 30, 2006 if, on such date, fifty percent
(50%) or more of the Registrable Securities under the October Rights Agreement
have not been registered pursuant to a Registration Statement declared effective
by the Commission. Such liquidated damages shall continue to accrue and be
payable until all Registrable Securities under the October Rights Agreement have
been registered pursuant to a Registration Statement declared effective by the
Commission.

     (d)  Any Event of Default (as defined in the 7% convertible debentures or
10% senior secured debentures issued by the Company to the Purchasers, as
applicable) arising from the Company's breach of Section 2 of the Rights
Agreements is hereby waived, subject to the Company's compliance with Section 2
of the Rights Agreements, as amended.

     4.   Effective Date of Second Amendment. This Second Amendment shall be
effective when executed by holders of seventy five percent (75%) of the
outstanding Registrable Securities under each of the August Rights Agreement and
the October Rights Agreement.

     5.   Reference to the Agreement. On and after the effective date of this
Amendment, each reference in the August Rights Agreement or the October Rights
Agreement to "the Agreement," "this Agreement," "hereunder" and "hereof" or

                                       2

<PAGE>

words of like import shall refer to the August Rights Agreement or the October
Rights Agreement, (as applicable) as amended by the First Amendment and this
Second Amendment. The August Rights Agreement and the October Rights Agreement,
as amended by the First Amendment and this Second Amendment, are and shall
continue to be in full force and effect and are hereby in all respects ratified
and confirmed.

     6.   Governing Law. All questions concerning the construction, validity,
enforcement and interpretation of this Amendment shall be governed by and
construed and enforced in accordance with the internal laws of the State of New
York, without regard to the principles of conflicts of law thereof.

     7.   Counterparts. This Second Amendment may be executed in any number of
counterparts, each of which when so executed shall be deemed to be an original
and, all of which taken together shall constitute one and the same agreement. In
the event that any signature is delivered by facsimile transmission, such
signature shall create a valid binding obligation of the party executing (or on
whose behalf such signature is executed) the same with the same force and effect
as if such facsimile signature were the original thereof.

                                       3

<PAGE>

         IN WITNESS WHEREOF, the parties hereto have executed this Second
Amendment as of the date first above written.

                                 THE COMPANY:
                                 ------------

                                 INTRAOP MEDICAL CORPORATION

                                 By: /s/ Howard Solovei
                                    --------------------------------------------
                                    Name:  Howard Solovei
                                    Title: Chief Financial Officer

                                 THE PURCHASERS:
                                 --------------

                                 BUSHIDO MASTER CAPITAL FUND, LP

                                 By: /s/ Christopher Rossman
                                    --------------------------------------------
                                    Name:  Christopher Rossman
                                    Title: Managing Director

                                 GAMMA OPPORTUNITY CAPITAL PARTNERS, LP CLASS A

                                 By: /s/ Jonathan Knight
                                    --------------------------------------------
                                    Name:  Jonathan Knight
                                    Title: President/Director

                                 GAMMA OPPORTUNITY CAPITAL
                                 PARTNERS, LP CLASS C

                                 By: /s/ Jonathan Knight
                                     -------------------------------------------
                                     Name:  Jonathan Knight
                                     Title: President/Director

                                       4

<PAGE>

                                 SAMIR FINANCIAL, L.L.C.

                                 By: /s/ Mohammed H. Mirza
                                     -------------------------------------------
                                     Name:  Mohammed H. Mirza
                                     Title: Manager

                                 REGENMACHER HOLDINGS, LTD.

                                 By: /s/ Jonathan Knight
                                     -------------------------------------------
                                     Name:  Jonathan Knight
                                     Title: Director

                                 ABS SOS-PLUS PARTNERS LTD.

                                 By: /s/ Jonathan Knight
                                     -------------------------------------------
                                     Name:  Jonathan Knight
                                     Title: President

                                 DOLPHIN OFFSHORE PARTNERS, L.P.

                                 By: /s/ Peter E. Salas
                                     -------------------------------------------
                                     Name:  Peter E. Salas
                                     Title: General Partner

                                 ALPHA CAPITAL AG

                                 By: ___________________________________________
                                     Name:
                                     Title:

                                 CRESTVIEW CAPITAL MASTER, LLC
                                 By Crestview Capital Partners LLC,
                                 its sole manager

                                 By: /s/ Daniel I. Warsh
                                     -------------------------------------------
                                     Name:  Daniel I. Warsh
                                     Title: Manager

                                       5

<PAGE>

                                 MAGNETAR CAPITAL MASTER FUND, LTD.

                                 By:  Magnetar Financial, LLC
                                         Its: Investment Manager

                                 By:  /s/ Doug Litowitz
                                     -------------------------------------------
                                     Name:  Doug Litowitz
                                     Title: Counsel

                                       6

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