Document:

Exhibit

EXHIBIT 10.2

OPTION GRANT NOTICE 
UNDER THE 
US FOODS HOLDING CORP. 2019 LONG-TERM INCENTIVE PLAN 
(Time-Based Vesting Non-Qualified Stock Option Award)
US Foods Holding Corp. (the “Company”), pursuant to the US Foods Holding Corp. 2019 Long-Term Incentive Plan (the “Plan”), hereby grants to the Participant set forth below the number of Options (each Option representing the right to purchase one share of Common Stock) set forth below, at an Exercise Price per share as set forth below.  The Options are subject to all of the terms and conditions as set forth herein, in the Option Agreement attached hereto, and in the Plan, all of which are incorporated herein in their entirety.  Capitalized terms not otherwise defined herein shall have the meaning set forth in the Plan.
	
		
	Participant:
	[Insert Participant Name]

	Date of Grant:
	[Insert Grant Date]

	Number of Options:
	[Insert Number of Options]

	Exercise Price:
	[Insert Exercise Price]

	Option Period Expiration Date:
	[Insert Expiration Date]

	Type of Option:
	Non-qualified Stock Option

	Vesting Schedule:
	 

	

Provided that the Participant has not undergone a Termination at the time of each of the following dates:

•    One-third (1⁄3) of the Options (rounded down to the nearest whole share underlying such Option) will vest and become exercisable on the first (1st) anniversary of the Date of Grant;
•    One-third (1⁄3) of the Options (rounded down to the nearest whole share underlying such Option) will vest and become exercisable on the second (2nd) anniversary of the Date of Grant; and
•    The remaining unvested Options will vest and become exercisable on the third (3rd) anniversary of the Date of Grant; 

provided, however, that the Options shall, upon the earliest to occur of the following circumstances:

(i)    fully vest and become exercisable immediately prior to a Change in Control if the Options would not otherwise be continued, converted, assumed, or replaced by the Company, a member of the Company Group or a successor entity thereto, or provided such other treatment as determined by the Committee;
(ii)    fully vest and become exercisable immediately upon the Participant’s Termination by the Service Recipient without Cause or by such Participant for Good Reason (as defined in the Option Agreement) within the eighteen (18)-month period immediately following a Change in Control to the extent the Options are continued, converted, assumed, or replaced by the Company, a member of the Company Group or a successor entity thereto; 
(iii)    fully vest and become exercisable immediately upon the Participant’s Termination due to Disability or death; or 
(iv)    continue to vest in accordance with the Vesting Schedule set forth above in the event of the Participant’s Termination due to Retirement (as defined in the Option Agreement), subject to the Participant’s continued compliance with the Option Agreement and any employment, service, non-competition, non-solicitation, restrictive covenant, confidentiality, intellectual property or similar agreement with the Company, a member of the Company Group or a successor entity thereto; provided, however, such Participant shall not be entitled to such vesting treatment in the event of the Participant’s Termination on or prior to the one-year anniversary of the Date of Grant. 

*        *        *

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THE UNDERSIGNED PARTICIPANT ACKNOWLEDGES RECEIPT OF THIS OPTION GRANT NOTICE, THE OPTION AGREEMENT AND THE PLAN, AND, AS AN EXPRESS CONDITION TO THE GRANT OF OPTIONS HEREUNDER, AGREES TO BE BOUND BY THE TERMS OF THIS OPTION GRANT NOTICE, THE OPTION AGREEMENT AND THE PLAN.
US FOODS HOLDING CORP.                         PARTICIPANT
By:    /s/ David Works                                     
Name:    David Works
Title:      Executive Vice President, 
Chief Human Resources Officer

OPTION AGREEMENT 
UNDER THE 
US FOODS HOLDING CORP. 2019 LONG-TERM INCENTIVE PLAN 
Pursuant to the Option Grant Notice (the “Grant Notice”) delivered to the Participant (as defined in the Grant Notice), and subject to the terms of this Option Agreement (this “Option Agreement”) and the US Foods Holding Corp. 2019 Long-Term Incentive Plan (the “Plan”), US Foods Holding Corp. (the “Company”) and the Participant agree as follows.  Capitalized terms not otherwise defined herein shall have the same meaning as set forth in the Plan or the Grant Notice.
1.Grant of Option.  The Company hereby grants to the Participant the number of Options provided in the Grant Notice (with each Option representing the right to purchase one share of Common Stock), at an Exercise Price per share as provided in the Grant Notice.  
2.    Vesting.  Subject to the terms of this Option Agreement and the Plan, the Options shall vest as provided in the Grant Notice.
3.    Exercise of Options Following Termination.  The Options shall be exercisable following the Participant’s Termination according to the following terms and conditions: (a) upon the Participant’s Termination by the Service Recipient for Cause, all outstanding Options (whether vested or unvested) granted to such Participant shall immediately terminate and expire; (b) upon the Participant’s Termination due to death or Disability, the Options shall remain exercisable for one (1) year thereafter (but in no event beyond the Option Period Expiration Date); (c) upon the Participant’s Termination due to Retirement, the Options shall remain exercisable until the earlier of (i) the five (5)-year anniversary of such Termination and (ii) the Option Period Expiration Date; and (d) upon the Participant’s Termination for any other reason, each outstanding unvested Option granted to such Participant shall immediately terminate and expire, and each outstanding vested Option shall remain exercisable for ninety (90) days thereafter (but in no event beyond the Option Period Expiration Date).   
4.    Method of Exercising Options.  The Options may be exercised by the delivery of notice of the number of Options that are being exercised accompanied by payment in full of the Exercise Price applicable to the Options so exercised.  Such notice shall be delivered either (a) in writing to the Company at its principal office or at such other address as may be established by the Committee, to the attention of the Company Secretary, or (b) to a third-party plan administrator as may be arranged for by the Company or the Committee from time to time for purposes of the administration of outstanding Options under the Plan, in each case as communicated to the Participant by the Company from time to time.  Payment of the aggregate Exercise Price may be made:  (i) in cash, check, cash equivalent, and/or shares of Common Stock valued at the Fair Market Value at the time the Option is exercised (including, pursuant to procedures approved by the Committee, by means of attestation of ownership of a sufficient number of shares of Common Stock in lieu of actual issuance of such shares to the Company); provided that such shares of Common Stock are not subject to any pledge or other security interest; (ii) if there is a public market for the shares of Common Stock at the time of exercise, by means of a broker-assisted “cashless exercise” pursuant to which the Company is delivered (including telephonically to the extent permitted by the Committee) a copy of irrevocable instructions to a 

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stockbroker to sell the shares of Common Stock otherwise issuable upon the exercise of the Option and to deliver promptly to the Company an amount equal to the Exercise Price; or (iii) a “net exercise” procedure effected by withholding the minimum number of shares of Common Stock otherwise issuable in respect of the Option that is needed to pay the Exercise Price and any Federal, state, local, and non-U.S. income, employment, and any other applicable taxes required to be withheld.
5.    Issuance of Shares.  Following the exercise of an Option hereunder, as promptly as practical after receipt of such notification and full payment of such Exercise Price and any required income or other tax withholding amount (as provided in Section 9 hereof), the Company shall issue or transfer, or cause such issue or transfer, to the Participant the number of shares with respect to which the Options have been so exercised, and shall either (a) deliver, or cause to be delivered, to the Participant a certificate or certificates therefor, registered in the Participant’s name, or (b) cause such shares to be credited to the Participant’s account at the third-party plan administrator.
6.    Definitions.
(a)    The term “Good Reason” as used in the Grant Notice or in this Option Agreement shall, in the case of any Participant who is party to an employment, service or similar agreement with the Company, any member of the Company Group or any successor entity thereto that contains a definition of “Good Reason”, mean and refer to the definition set forth in such agreement, and in the case of any other Participant, “Good Reason” shall mean: (A) a material diminution in the Participant’s base salary or annual bonus opportunity; (B) any material diminution in the Participant’s authority, duties or responsibilities; or (C) the relocation of the Participant’s principal work location by more than fifty (50) miles; provided that none of these events shall constitute Good Reason unless the Company fails to cure such event within thirty (30) days after receipt from the Participant of written notice of the event which constitutes Good Reason; provided, further, that “Good Reason” shall cease to exist for an event on the sixtieth (60th) day following the later of its occurrence or the Participant’s knowledge thereof, unless the Participant has given the Company written notice thereof prior to such date.  Notwithstanding anything herein to the contrary, for purposes of the last proviso of the immediately foregoing sentence, a series of related events shall be deemed to have occurred on the date upon which the last event in such series of related events has occurred.  In the event of the Participant’s Termination due to Good Reason, such Termination must occur within sixty (60) days following the expiration of the Company cure period described above. 
(b)    Whenever the word “Participant” is used in this Option Agreement under circumstances where the provision should logically be construed to apply to the executors, the administrators, or the person or persons to whom the Options may be transferred by will or by the laws of descent and distribution, the word “Participant” shall be deemed to include such person or persons.
(c)    The term “Retirement” shall mean a Termination by the Participant, if on the date of such Termination, the Participant shall have attained age sixty (60) and a minimum of five (5) years of continuous service as an employee with the Company Group. 
7.    Non-Transferability.  The Options are not transferable by the Participant except to Permitted Transferees in accordance with Section 13(b) of the Plan.  Except as otherwise provided herein, no assignment or transfer of the Options, or of the rights represented thereby, whether voluntary or involuntary, by operation of law or otherwise, shall vest in the assignee or transferee any interest or right herein whatsoever, but immediately upon such assignment or transfer the Options shall terminate and become of no further effect.
8.    Rights as Stockholder.  The Participant or a Permitted Transferee of the Options shall have no rights as a stockholder with respect to any share of Common Stock covered by an Option until the Participant shall have become the holder of record or the beneficial owner of such Common Stock, and no adjustment shall be made for dividends or distributions or other rights in respect of such share of Common Stock for which the record date is prior to the date upon which the Participant shall become the holder of record or the beneficial owner thereof.
9.    Tax Withholding.  The provisions of Section 13(d)(i) of the Plan are incorporated herein by reference and made a part hereof.  The Participant shall satisfy such Participant’s withholding liability referred to in Section 13(d)(i) of the Plan by having the Company withhold from the number of shares of Common Stock otherwise issuable or deliverable pursuant to the exercise or settlement of the Award a number of shares with a Fair Market Value equal to such withholding liability, provided that the number of such shares may not have a Fair Market Value greater than the minimum required statutory withholding liability unless determined by the Committee not to result in adverse accounting consequences.

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10.    Notice.  Every notice or other communication relating to this Option Agreement between the Company and the Participant shall be in writing, and shall be mailed to or delivered to the party for whom it is intended at such address as may from time to time be designated by such party in a notice mailed or delivered to the other party as herein provided; provided that, unless and until some other address be so designated, all notices or communications by the Participant to the Company shall be mailed or delivered to the Company at its principal executive office, to the attention of the Company Secretary, and all notices or communications by the Company to the Participant may be given to the Participant personally or may be mailed to the Participant at the Participant’s last known address, as reflected in the Company’s records.  Notwithstanding the above, all notices and communications between the Participant and any third-party plan administrator shall be mailed, delivered, transmitted or sent in accordance with the procedures established by such third-party plan administrator and communicated to the Participant from time to time.
11.    No Right to Continued Service.  This Option Agreement does not confer upon the Participant any right to continue as an employee or service provider to the Service Recipient.
12.    Binding Effect.  This Option Agreement shall be binding upon the heirs, executors, administrators and successors of the parties hereto.
13.    Protected Rights.  Nothing contained in this Option Agreement or the Plan is intended to limit the Participant’s ability to (a) report possible violations of law or regulation to, or file a charge or complaint with, any Government Agency, (b) communicate with any Government Agency or otherwise participate in any investigation or proceeding that may be conducted by any Government Agency, including providing documents or other information, without notice to the Company, or (c) under applicable United States federal law to (i) disclose in confidence trade secrets to federal, state, and local government officials, or to an attorney, for the sole purpose of reporting or investigating a suspected violation of law or (ii) disclose trade secrets in a document filed in a lawsuit or other proceeding, but only if the filing is made under seal and protected from public disclosure. 
14.    Waiver and Amendments.  Except as otherwise set forth in Section 12 of the Plan, any waiver, alteration, amendment or modification of any of the terms of this Option Agreement shall be valid only if made in writing and signed by the parties hereto; provided, however, that any such waiver, alteration, amendment or modification is consented to on the Company’s behalf by the Committee.  No waiver by either of the parties hereto of their rights hereunder shall be deemed to constitute a waiver with respect to any subsequent occurrences or transactions hereunder unless such waiver specifically states that it is to be construed as a continuing waiver.
15.    Governing Law.  This Option Agreement shall be construed and interpreted in accordance with the laws of the State of Delaware, without regard to the principles of conflicts of law thereof.  Notwithstanding anything contained in this Option Agreement, the Grant Notice or the Plan to the contrary, if any suit or claim is instituted by the Participant or the Company relating to this Option Agreement, the Grant Notice or the Plan, the Participant hereby submits to the exclusive jurisdiction of and venue in the courts of Delaware.
16.    Plan.  The terms and provisions of the Plan are incorporated herein by reference.  In the event of a conflict or inconsistency between the terms and provisions of the Plan and the provisions of this Option Agreement, the Plan shall govern and control.  

2EX-4.1

 Exhibit 4.1 

FIFTH THIRD BANCORP 
 TO

 WILMINGTON TRUST COMPANY, 

Trustee 
 Tenth
Supplemental Indenture 
 Dated as of May 5, 2020 

SENIOR DEBT SECURITIES 

 TABLE OF CONTENTS 

 

					
	 ARTICLE 1 SCOPE OF TENTH
SUPPLEMENTAL INDENTURE
	  	 	2	 
	 Section 1.1 Scope
	  	 	2	 
		
	 ARTICLE 2 DEFINITIONS
	  	 	2	 
	 Section 2.1 Definitions and Other Provisions of General Application
	  	 	2	 
	 Section 2.2 Other Definitions
	  	 	3	 
		
	 ARTICLE 3 FORM AND TERMS OF
THE NOTES
	  	 	3	 
	 Section 3.1 Form and Dating
	  	 	3	 
	 Section 3.2 Terms of the Senior Notes
	  	 	4	 
		
	 ARTICLE 4 SUPPLEMENTAL INDENTURES
	  	 	16	 
	 Section 4.1 Supplemental Indentures
	  	 	16	 
		
	 ARTICLE 5 MISCELLANEOUS
	  	 	17	 
	 Section 5.1 Trust Indenture Act of 1939
	  	 	17	 
	 Section 5.2 Governing Law
	  	 	17	 
	 Section 5.3 Duplicate Originals
	  	 	17	 
	 Section 5.4 Legal Holidays
	  	 	17	 
	 Section 5.5 Separability
	  	 	17	 
	 Section 5.6 Ratification
	  	 	17	 
	 Section 5.7 Effectiveness
	  	 	17	 
	 Section 5.8 Successors
	  	 	17	 
	 Section 5.9 Trustee’s Disclaimer
	  	 	17	 
		
	 EXHIBIT A
	  	 	A-1	 

  
 i 

 TENTH SUPPLEMENTAL INDENTURE 

TENTH SUPPLEMENTAL INDENTURE (this “Tenth Supplemental Indenture”), dated as of May 5, 2020 between FIFTH THIRD BANCORP, a
corporation duly organized and existing under the laws of the State of Ohio (the “Company”), having its principal office at Fifth Third Center, 38 Fountain Square Plaza, Cincinnati, Ohio and Wilmington Trust Company, a trust company
duly organized and existing under the laws of the State of Delaware, as trustee (the “Trustee”). 
 RECITALS OF THE
COMPANY 
 WHEREAS, the Company and the Trustee executed and delivered an Indenture, dated as of April 30, 2008 (the
“Base Indenture” and as supplemented by this Tenth Supplemental Indenture, the “Indenture”), to provide for the issuance by the Company from time to time of its unsecured debentures, notes or other evidences of
indebtedness (the “Securities”); 
 WHEREAS, Sections 201, 301 and 901 of the Base Indenture provide that the
Company, when authorized by a Board Resolution, and the Trustee, at any time and from time to time, may enter into one or more indentures supplemental to the Indenture, without the consent of any Holders, to, among other things, establish the terms
of Securities of any series as permitted by the Indenture; 
 WHEREAS, the issuance and sale of $500,000,000 aggregate principal
amount of a new series of the Securities of the Company designated as its 1.625% Senior Notes due 2023 (the “2023 Notes,”) have been authorized by resolutions adopted by the board of directors of the Company; 

WHEREAS, the issuance and sale of $750,000,000 aggregate principal amount of a new series of the Securities of the Company designated
as its 2.550% Senior Notes due 2027 (the “2027 Notes,” collectively with the 2023 Notes, the “Senior Notes” or the “Notes”) have been authorized by resolutions adopted by the board of directors of
the Company 
 WHEREAS, the Company desires to issue and sell $1,250,000,000 aggregate principal amount of the Senior Notes as of the
date hereof; 
 WHEREAS, the Company desires to establish the terms of the Notes; 

WHEREAS, all things necessary to make this Tenth Supplemental Indenture a legal and binding supplement to the Base Indenture in
accordance with its terms and the terms of the Base Indenture have been done; 
 WHEREAS, the Company has complied with all
conditions precedent provided for in the Base Indenture relating to this Tenth Supplemental Indenture; and 
 WHEREAS, the Company
has requested that the Trustee execute and deliver this Tenth Supplemental Indenture. 

 NOW, THEREFORE: 

For and in consideration of the premises stated herein and the purchase of the Notes by the Holders thereof, the Company and the Trustee
covenant and agree, for the equal and proportionate benefit of the Holders of the Notes, as follows: 
 ARTICLE 1 

Scope of Tenth Supplemental Indenture 

Section 1.1 Scope. This Tenth Supplemental Indenture constitutes a supplement to the Base Indenture and an integral
part of the Indenture and shall be read together with the Base Indenture as though all the provisions thereof are contained in one instrument. Except as expressly amended by the Tenth Supplemental Indenture, the terms and provisions of the Base
Indenture shall remain in full force and effect. Notwithstanding the foregoing, this Tenth Supplemental Indenture shall only apply to the Notes. 

ARTICLE 2 
 Definitions

 Section 2.1 Definitions and Other Provisions of General Application. For all purposes of this Tenth
Supplemental Indenture unless otherwise specified herein: 
  

	 	(a)	 all terms used in this Tenth Supplemental Indenture which are not otherwise defined herein shall have the
meanings they are given in the Base Indenture; 

  

	 	(b)	 the provisions of general application stated in Sections 102 through 112 of the Base Indenture shall apply to
this Tenth Supplemental Indenture, except that the words “herein,” “hereof,” “hereto” and “hereunder” and other words of similar import refer to this Tenth Supplemental Indenture as
a whole and not to the Base Indenture or any particular Article, Section or other subdivision of the Base Indenture or this Tenth Supplemental Indenture; 

  

	 	(c)	 Section 101 of the Base Indenture is amended and supplemented, solely with respect to the Notes, by
inserting the following additional defined term in its appropriate alphabetical position: 

 “Issue Date”
means May 5, 2020. 
  

	 	(d)	 Section 101 of the Base Indenture is amended and supplemented, solely with respect to the Notes, by
replacing the corresponding defined terms in the Base Indenture with the following defined terms: 

 “Applicable
Procedures” means, with respect to any transfer, transaction or other action involving a Global Security or any beneficial interest therein, the rules and procedures of the Depositary for such Security, in each case to the extent applicable
to such transfer, transaction or other action as in effect from time to time. 

  
 2 

 “Business Day” means any day that is not a Saturday or Sunday, and that is
not a day on which banking institutions in the City of New York are authorized or obligated by law, regulation or executive order to close.

“Business Day Convention” means if any Interest Payment Date, redemption date or the maturity date of the Notes falls
on a day which is not a Business Day, the related payment of principal of, or interest on, the Notes will be made on the next day which is a Business Day with the same force and effect as if made on the date such payment was due, and no interest
shall accrue on the amount payable for the period from and after such Interest Payment Date, redemption date or maturity date, as the case may be. 

“Corporate Trust Office” for administration of this Indenture means the corporate trust office of the Trustee located at
Rodney Square North, 1100 N. Market Street, Wilmington, DE 19890-0001, Attention: Fifth Third Bancorp Administrator, or such other office, designated by the Trustee by written notice to the Company, at which at any particular time its corporate
trust business shall be administered. 
 Section 2.2 Other Definitions. Each of the following terms is defined in
the section set forth opposite such term: 
  

			
	 TERM
	  	 SECTION

	“Dodd-Frank Act”	  	Section 3.2(q)
	“SIPA”	  	Section 3.2(q)

 ARTICLE 3 

Form and Terms of the Notes 

Section 3.1 Form and Dating. 
  

	 	(a)	 The 2023 Notes shall be substantially in the form of Exhibit A attached hereto and the 2027 Notes shall
be substantially in the form of Exhibit B attached hereto. The Notes shall be executed on behalf of the Company by its Chairman of the Board, its Vice Chairman of the Board, its President or one of its Vice Presidents, attested by its
Secretary or one of its Assistant Secretaries. The Notes may have a legend or legends or endorsements as may be required to comply with any law or with any rules of any securities exchange or usage. The Notes shall be dated the date of their
authentication. 

  

	 	(b)	 The terms contained in the Notes shall constitute, and are hereby expressly made, a part of the Indenture as
supplemented by this Tenth Supplemental Indenture and the Company and the Trustee, by their execution and delivery of this Tenth Supplemental Indenture, expressly agree to such terms and provisions and to be bound thereby. 

  
 3 

 Section 3.2 Terms of the 2023 Notes. The following terms relating to
the 2023 Notes are hereby established:  
  

	 	(a)	 Title. The 2023 Notes shall constitute a series of Securities having the title “Fifth Third Bancorp
1,625% Senior Notes due 2023”, the CUSIP number 316773 CZ1, and the ISIN number US316773CZ10. 

  

	 	(b)	 Principal Amount. The aggregate principal amount of the 2023 Notes that may be authenticated and
delivered under the Indenture, as amended hereby, shall be $500,000,000 on the Issue Date. Provided that no Event of Default has occurred and is continuing with respect to the 2023 Notes, the Company may, without notice to or the consent of the
Holders, create and issue additional Securities having the same terms as (except as described below), and ranking equally and ratably with, the 2023 Notes in all respects and so that such additional Securities will be consolidated and form a single
series with, and have the same terms as to status, redemption or otherwise as, the 2023 Notes initially issued, except for the issue date, the issue price and the initial Interest Payment Date, provided that if such additional Securities are not
fungible with the 2023 Notes for U.S. federal income tax purposes, such additional Securities will be issued with a separate CUSIP number. 

  

	 	(c)	 Person to Whom Interest is Payable. Interest payable, and punctually paid or duly provided for, on any
Interest Payment Date will be paid to the Person in whose name the 2023 Notes are registered at the close of business on the Regular Record Date for such interest, which shall be April 20 or October 21 (whether or not a Business Day), as
the case may be, next preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name
the Note is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of 2023 Notes of this series not less than 10 days prior to such
Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the 2023 Notes may be listed and upon such notice as may be required by such exchange, as provided for
in the Base Indenture. 

  

	 	(d)	 Maturity Date. The entire outstanding principal of the 2023 Notes shall be payable on May 5, 2023.

  

	 	(e)	 Interest. The rate at which the 2023 Notes shall bear interest shall be 1.625% per annum; the date from
which interest shall accrue on the 2023 Notes shall be May 5, 2020 or the most recent Interest Payment Date to which interest has been paid or duly provided for; and the Interest Payment Dates for the 2023 Notes shall be May 5 and
November 5 of each year, beginning November 5, 2020. 

  

	 	(f)	 Place of Payment of Principal and Interest. Payment of the principal of (and premium, if any) and
interest on the 2023 Notes will be made at the office or 

  
 4 

	 	
agency of the Company maintained for that purpose in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts;
provided, however, that at the option of the Company payment of interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register. The Company shall make, or cause
the Paying Agent to make, all payments of principal and interest on Global Securities in immediately available funds to the Depositary or its nominee, in accordance with Applicable Procedures. 

 

	 	(g)	 Redemption. 

  

	 	(i)	 The 2023 Notes will be redeemable at the Company’s option, in whole or in part, at any time or from time
to time, on or after November 2, 2020, and prior to the Applicable Par Call Date (as defined below), in each case at a redemption price, plus accrued and unpaid interest thereon, if any, to, but excluding, the redemption date, equal to the
greater of: 

  

	 	a.	 100% of the aggregate principal amount of the 2023 Notes being redeemed on that redemption date; and

  

	 	b.	 the sum of the present values of the remaining scheduled payments of principal and interest on the 2023 Notes
being redeemed that would be due if the 2023 Notes to be redeemed matured on the Applicable Par Call Date (not including any portion of such payments of interest accrued to the redemption date) discounted to the redemption date on a semi-annual
basis (assuming a 360-day year consisting of twelve 30-day months) at the applicable Treasury Rate plus the Applicable Spread for the 2023 Notes to be redeemed. The
Trustee (including in its capacity as Paying Agent), shall have no responsibility to calculate any amounts in this Section 3.2(g)(b) and shall be entitled to conclusively rely upon calculation thereof as provided by the Company to the Trustee
and Paying Agent. 

  

	 	(ii)	 On and after the Applicable Par Call Date, the 2023 Notes will be redeemable, in whole or in part, at any time
and from time to time, at the Company’s option at a redemption price equal to 100% of the aggregate principal amount of the 2023 Notes being redeemed, plus accrued and unpaid interest thereon, if any, to, but excluding, the redemption date. The
principal amount of any note remaining outstanding after redemption in part shall be minimum denominations of $2,000 or any integral multiple of $1,000 in excess thereof. 

 

	 	(iii)	 If the Company redeems 2023 Notes at its option, then (a) notwithstanding the foregoing, installments of
interest on the 2023 Notes that are due and payable on any interest payment date falling on or prior to a redemption date for the 2023 Notes will be payable on that interest payment date to the registered holders thereof as of the close of business
on the relevant record date according 

  
 5 

	 	
to the terms of the 2023 Notes and the Indenture and (b) the redemption price will, if applicable, be calculated on the basis of a 360-day year
consisting of twelve 30-day months. 

  

	 	(iv)	 For the purposes of this Section, the terms below are defined as follows: 

“Applicable Par Call Date” means April 5, 2023. 

“Applicable Spread” means 25 basis points. 

“Comparable Treasury Issue” means the United States Treasury security selected by an Independent Investment Banker as having an
actual or interpolated maturity comparable to the remaining term of the 2023 Notes to be redeemed (assuming the 2023 Notes matured on the Applicable Par Call Date) that would be utilized, at the time of selection and in accordance with customary
financial practice, in pricing new issues of corporate debt securities of comparable maturity to such remaining term. 
 “Comparable
Treasury Price” means, with respect to any redemption date for 2023 Notes to be redeemed, (A) if the Independent Investment Banker obtains four or more applicable Reference Treasury Dealer Quotations, the average of all such Reference
Treasury Dealer Quotations after excluding the highest and lowest of such applicable Reference Treasury Dealer Quotations or (B) if the Independent Investment Banker obtains fewer than four applicable Reference Treasury Dealer Quotations, the
average of all such Reference Treasury Dealer Quotations. 
 “Independent Investment Banker” means one of the Reference Treasury
Dealers appointed by the Company to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealers” mean,
with respect to the 2023 Notes offered hereby, (A) Morgan Stanley & Co. LLC, Fifth Third Securities, Inc., J.P. Morgan Securities LLC, and RBC Capital Markets, LLC (or their respective affiliates which are Primary Treasury Dealers (as
defined below)), and their respective successors; provided, however, that if any of the foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will substitute
therefor another Primary Treasury Dealer; and (B) any other Primary Treasury Dealer(s) selected by us. 
 “Reference Treasury
Dealer Quotation” means, with respect to each Reference Treasury Dealer and any redemption date for 2023 Notes to be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable
Treasury Issue for the 2023 Notes to be redeemed on such redemption date (expressed in each case as a percentage of its aggregate principal amount) quoted in writing to the Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m.
(New York City time) on the third business day preceding such redemption date. As used in the preceding sentence, “business day” means any day (other than a Saturday or Sunday) on which banking institutions in the City of New York are not
authorized or obligated by law or executive order to remain closed. 

  
 6 

 “Treasury Rate” means, with respect to any redemption date applicable to the 2023
Notes, the rate per annum equal to the semi-annual equivalent yield to maturity of the Comparable Treasury Issue for the 2023 Notes to be redeemed on such redemption date, assuming a price for the Comparable Treasury Issue (expressed as a percentage
of its aggregate principal amount) equal to the applicable Comparable Treasury Price for such redemption date. 
  

	 	(v)	 If the Company elects to redeem the 2023 Notes (in whole or in part), it must (A) notify the Trustee of
the intended redemption date and provide a draft notice with respect to the potential redemption at least 5 Business Days prior to the date on which it intends to provide notice, or if requested, have the Trustee provide notice, of such redemption
to Holders (unless a shorter period is satisfactory to the Trustee) and (B) deliver to the Trustee the final notice to be sent to Holders and an Officers’ Certificate with respect to the Company’s election to redeem the 2023 Notes (in
whole or in part) on the date on which the Company provides notice. If fewer than all of the 2023 Notes are being redeemed, the Trustee will select the 2023 Notes to be redeemed by lot, pro rata or by any other method the Trustee in its sole
discretion deems fair and appropriate, and in the case of any Global Security, in accordance with the Applicable Procedures, in minimum denominations of $2,000 or any integral multiples of $1,000 in excess thereof. The Trustee will notify the
Company promptly of the 2023 Notes or portions of 2023 Notes to be called for redemption. Notice of redemption must be sent by the Company or at the Company’s request, by the Trustee by first class mail or, with respect to any Global Security,
the Applicable Procedures, in the name and at the expense of the Company, to Holders whose 2023 Notes are to be redeemed at least 10 days but not more than 60 days before the redemption date. 

 

	 	(vi)	 The notice of redemption will identify the 2023 Notes to be redeemed and will include or state the following:

  

	 	a.	 the redemption date; 

 

	 	b.	 the redemption price, including the portion thereof representing any accrued interest; 

 

	 	c.	 the place or places where 2023 Notes are to be surrendered for redemption; 

 

	 	d.	 2023 Notes called for redemption must be so surrendered in order to collect the redemption price;

  

	 	e.	 on the redemption date the redemption price will become due and payable on 2023 Notes called for redemption,
and interest on 2023 Notes called for redemption will cease to accrue on and after the redemption date; 

  
 7 

	 	f.	 if any 2023 Note is redeemed in part, on and after the redemption date, upon surrender of such 2023 Note, new
2023 Notes equal in principal amount to the unredeemed portion will be issued; and 

  

	 	g.	 if any Note contains a CUSIP, ISIN, or CINS number, no representation is being made as to the correctness of
the CUSIP, ISIN, or CINS number either as printed on the 2023 Notes or as contained in the notice of redemption and that the Holder should rely only on the other identification numbers printed on the 2023 Notes. 

 

	 	(vii)	 Once notice of redemption is sent to the Holders, 2023 Notes called for redemption become due and payable at
the redemption price on the redemption date, and upon surrender of the 2023 Notes called for redemption, the Company shall redeem such 2023 Notes at the redemption price. Unless the Company defaults in the payment of the redemption price, commencing
on the redemption date 2023 Notes redeemed will cease to accrue interest. Upon surrender of any Note redeemed in part, the Holder will receive a new Note equal in principal amount to the unredeemed portion of the surrendered Note. The principal
amount after redemption in part shall be in minimum denominations of $2,000 or any integral multiple of $1,000 in excess thereof. 

  

	 	(h)	 Sinking Fund. There shall be no sinking fund for the 2023 Notes. 

 

	 	(i)	 Denomination. The 2023 Notes and any beneficial interest in the 2023 Notes shall be in minimum
denominations of $2,000 or any integral multiples of $1,000 in excess thereof. 

  

	 	(j)	 Index. Payment of interest on the 2023 Notes will not be determined with reference to any index or
formula. 

  

	 	(k)	 Currency of the 2023 Notes. The 2023 Notes shall be denominated, and payment of principal and interest
of the 2023 Notes shall be payable in, the currency of the United States of America. 

  

	 	(l)	 Currency of Payment. The principal of and interest on the 2023 Notes shall be payable in the
currency of the United States of America. 

  

	 	(m)	 Acceleration. 100% of the principal amount of the 2023 Notes shall be payable upon acceleration
(whether automatic or by declaration) of the maturity thereof. 

  

	 	(n)	 [Reserved.] 

  

	 	(o)	 Defeasance. Article 13 of the Base Indenture shall apply to the 2023 Notes. 

 

	 	(p)	 Registered Form. The 2023 Notes shall be issuable as registered Global Securities, and the depositary
for the 2023 Notes shall be the Depository Trust 

  
 8 

	 	
Company, a New York Corporation (“DTC”), or any successor depositary appointed by the Company within 90 days of the termination of services of DTC (or any successor to DTC). Sections
204 and 305 of the Base Indenture shall apply to the 2023 Notes. 

  

	 	(q)	 Events of Default. The Events of Default provided for in Section 501 of the Base Indenture shall
apply to the 2023 Notes, provided that the text of clauses (6) and (7) of Section 501 shall be substituted with the following: 

“(6) (A) the entry by a court having jurisdiction in the premises of (i) a decree or order for relief in respect of
the Company or any Principal Subsidiary Bank in an involuntary case or proceeding under any applicable Federal or State bankruptcy, insolvency, reorganization or other similar law, (ii) a decree or order adjudging the Company or any Principal
Subsidiary Bank bankrupt or insolvent, or approving as properly filed a petition seeking reorganization, arrangement, adjustment or composition of or in respect of the Company or any Principal Subsidiary Bank under any applicable Federal or State
law, or appointing a custodian, receiver, liquidator, assignee, trustee, sequestrator or other similar official of the Company or any Principal Subsidiary Bank or of any substantial part of its property, or ordering the winding up or liquidation of
its affairs, and, in the case of each of (A)(i) and (ii), the continuance of any such decree or order for relief or any such other decree or order unstayed and in effect for a period of 60 consecutive days, (B) the appointment of the Federal
Deposit Insurance Corporation as receiver or conservator of any Principal Subsidiary Bank or any substantial part of the property of the Company or any Principal Subsidiary Bank pursuant to the Federal Deposit Insurance Act, as amended, or
(C) the appointment of the Federal Deposit Insurance Corporation, the Securities Investment Protection Corporation, other Federal or State agency or other person as receiver or trustee of the Company or any Principal Subsidiary Bank or of any
substantial part of the property of the Company or any Principal Subsidiary Bank pursuant to Title II of the Dodd-Frank Act or SIPA; or 

(7) the commencement by the Company or any Principal Subsidiary Bank of a voluntary case or proceeding under any applicable
Federal or State bankruptcy, insolvency, reorganization or other similar law or of any other case or proceeding to be adjudicated a bankrupt or insolvent, or the consent by it to the entry of a decree or order for relief in respect of the Company or
any Principal Subsidiary Bank in an involuntary case or proceeding under any applicable Federal or State bankruptcy, insolvency, reorganization or other similar law or to the commencement of any bankruptcy or insolvency case or proceeding against
it, or the filing by it of a petition or answer or consent seeking reorganization or relief under any applicable Federal or State law, or the consent by it to the filing of such petition or to the appointment of or taking possession by a custodian,
receiver, liquidator, conservator, assignee, trustee, sequestrator or other similar official of the Company or any Principal Subsidiary Bank or of any substantial part of its property, including pursuant to the Federal Deposit Insurance Act or

  
 9 

 
SIPA, or the making by it of an assignment for the benefit of creditors, or the admission by it in writing of its inability to pay its debts generally as they become due, or the taking of
corporate action by the Company or any Principal Subsidiary Bank in furtherance of any such action; or” 
  

	 	(r)	 Covenants. The covenants set forth in Article 10 of the Base Indenture shall apply to the 2023 Notes.

  

	 	(s)	 Additional Terms. Other terms applicable to the 2023 Notes are as otherwise provided for in the
Base Indenture, as supplemented by this Tenth Supplemental Indenture. 

  

	 	(t)	 Day Count Convention. Interest on the 2023 Notes shall be computed on the basis of a 360-day year comprised of twelve 30-day months. 

Section 3.3 Terms of the 2027 Notes. The following terms relating to the 2027 Notes are hereby established:  

 

	 	(a)	 Title. The 2027 Notes shall constitute a series of Securities having the title “Fifth Third Bancorp
2.550% Senior Notes due 2027”, the CUSIP number 316773 DA5, and the ISIN number US316773DA59. 

  

	 	(b)	 Principal Amount. The aggregate principal amount of the 2027 Notes that may be authenticated and
delivered under the Indenture, as amended hereby, shall be $750,000,000 on the Issue Date. Provided that no Event of Default has occurred and is continuing with respect to the 2027 Notes, the Company may, without notice to or the consent of the
Holders, create and issue additional Securities having the same terms as (except as described below), and ranking equally and ratably with, the 2027 Notes in all respects and so that such additional Securities will be consolidated and form a single
series with, and have the same terms as to status, redemption or otherwise as, the 2027 Notes initially issued, except for the issue date, the issue price and the initial Interest Payment Date, provided that if such additional Securities are not
fungible with the 2027 Notes for U.S. federal income tax purposes, such additional Securities will be issued with a separate CUSIP number. 

  

	 	(c)	 Person to Whom Interest is Payable. Interest payable, and punctually paid or duly provided for, on any
Interest Payment Date will be paid to the Person in whose name the 2027 Notes are registered at the close of business on the Regular Record Date for such interest, which shall be April 20 or October 21 (whether or not a Business Day), as
the case may be, next preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name
the Note is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of 2027 Notes of this series not less than 10 days prior to such
Special Record Date, or be paid at any time in any 

  
 10 

	 	
other lawful manner not inconsistent with the requirements of any securities exchange on which the 2027 Notes may be listed and upon such notice as may be required by such exchange, as provided
for in the Base Indenture. 

  

	 	(d)	 Maturity Date. The entire outstanding principal of the 2027 Notes shall be payable on May 5, 2027.

  

	 	(e)	 Interest. The rate at which the 2027 Notes shall bear interest shall be 2.550% per annum; the date from
which interest shall accrue on the 2027 Notes shall be May 5, 2020 or the most recent Interest Payment Date to which interest has been paid or duly provided for; and the Interest Payment Dates for the 2027 Notes shall be May 5 and
November 5 of each year, beginning November 5, 2020. 

  

	 	(f)	 Place of Payment of Principal and Interest. Payment of the principal of (and premium, if any) and
interest on the 2027 Notes will be made at the office or agency of the Company maintained for that purpose in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts;
provided, however, that at the option of the Company payment of interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register. The Company shall make, or cause
the Paying Agent to make, all payments of principal and interest on Global Securities in immediately available funds to the Depositary or its nominee, in accordance with Applicable Procedures. 

 

	 	(g)	 Redemption. 

  

	 	(i)	 The 2027 Notes will be redeemable at the Company’s option, in whole or in part, at any time or from time
to time, on or after November 2, 2020, and prior to the Applicable Par Call Date (as defined below), in each case at a redemption price, plus accrued and unpaid interest thereon, if any, to, but excluding, the redemption date, equal to the
greater of: 

  

	 	a.	 100% of the aggregate principal amount of the 2027 Notes being redeemed on that redemption date; and

  

	 	b.	 the sum of the present values of the remaining scheduled payments of principal and interest on the 2027 Notes
being redeemed that would be due if the 2027 Notes to be redeemed matured on the Applicable Par Call Date (not including any portion of such payments of interest accrued to the redemption date) discounted to the redemption date on a semi-annual
basis (assuming a 360-day year consisting of twelve 30-day months) at the applicable Treasury Rate plus the Applicable Spread for the 2027 Notes to be redeemed. The
Trustee (including in its capacity as Paying Agent), shall have no responsibility to calculate any amounts in this Section 3.2(g)(b) and shall be entitled to conclusively rely upon calculation thereof as provided by the Company to the Trustee
and Paying Agent. 

  
 11 

	 	(ii)	 On and after the Applicable Par Call Date, the 2027 Notes will be redeemable, in whole or in part, at any time
and from time to time, at the Company’s option at a redemption price equal to 100% of the aggregate principal amount of the 2027 Notes being redeemed, plus accrued and unpaid interest thereon, if any, to, but excluding, the redemption date. The
principal amount of any note remaining outstanding after redemption in part shall be minimum denominations of $2,000 or any integral multiple of $1,000 in excess thereof. 

 

	 	(iii)	 If the Company redeems 2027 Notes at its option, then (a) notwithstanding the foregoing, installments of
interest on the 2027 Notes that are due and payable on any interest payment date falling on or prior to a redemption date for the 2027 Notes will be payable on that interest payment date to the registered holders thereof as of the close of business
on the relevant record date according to the terms of the 2027 Notes and the Indenture and (b) the redemption price will, if applicable, be calculated on the basis of a 360-day year consisting of twelve 30-day months. 

  

	 	(iv)	 For the purposes of this Section, the terms below are defined as follows: 

“Applicable Par Call Date” means April 5, 2027. 

“Applicable Spread” means 35 basis points. 

“Comparable Treasury Issue” means the United States Treasury security selected by an Independent Investment Banker as having an
actual or interpolated maturity comparable to the remaining term of the 2027 Notes to be redeemed (assuming the 2027 Notes matured on the Applicable Par Call Date) that would be utilized, at the time of selection and in accordance with customary
financial practice, in pricing new issues of corporate debt securities of comparable maturity to such remaining term. 
 “Comparable
Treasury Price” means, with respect to any redemption date for 2027 Notes to be redeemed, (A) if the Independent Investment Banker obtains four or more applicable Reference Treasury Dealer Quotations, the average of all such Reference
Treasury Dealer Quotations after excluding the highest and lowest of such applicable Reference Treasury Dealer Quotations or (B) if the Independent Investment Banker obtains fewer than four applicable Reference Treasury Dealer Quotations, the
average of all such Reference Treasury Dealer Quotations. 
 “Independent Investment Banker” means one of the Reference Treasury
Dealers appointed by the Company to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealers” mean,
with respect to the 2027 Notes offered hereby, (A) Morgan Stanley & Co. LLC, Fifth Third Securities, Inc., J.P. Morgan Securities LLC, and RBC Capital Markets, LLC (or their respective affiliates which are Primary

  
 12 

 
Treasury Dealers (as defined below)), and their respective successors; provided, however, that if any of the foregoing shall cease to be a primary U.S. Government securities dealer in the United
States (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer; and (B) any other Primary Treasury Dealer(s) selected by us. 

“Reference Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and any redemption date for 2027 Notes to
be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Treasury Issue for the 2027 Notes to be redeemed on such redemption date (expressed in each case as a percentage of its
aggregate principal amount) quoted in writing to the Independent Investment Banker by such Reference Treasury Dealer at 5:00 p.m. (New York City time) on the third business day preceding such redemption date. As used in the preceding sentence,
“business day” means any day (other than a Saturday or Sunday) on which banking institutions in the City of New York are not authorized or obligated by law or executive order to remain closed. 

“Treasury Rate” means, with respect to any redemption date applicable to the 2027 Notes, the rate per annum equal to the semi-annual
equivalent yield to maturity of the Comparable Treasury Issue for the 2027 Notes to be redeemed on such redemption date, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its aggregate principal amount) equal to the
applicable Comparable Treasury Price for such redemption date. 
  

	 	(v)	 If the Company elects to redeem the 2027 Notes (in whole or in part), it must (A) notify the Trustee of
the intended redemption date and provide a draft notice with respect to the potential redemption at least 5 Business Days prior to the date on which it intends to provide notice, or if requested, have the Trustee provide notice, of such redemption
to Holders (unless a shorter period is satisfactory to the Trustee) and (B) deliver to the Trustee the final notice to be sent to Holders and an Officers’ Certificate with respect to the Company’s election to redeem the 2027 Notes (in
whole or in part) on the date on which the Company provides notice. If fewer than all of the 2027 Notes are being redeemed, the Trustee will select the 2027 Notes to be redeemed by lot, pro rata or by any other method the Trustee in its sole
discretion deems fair and appropriate, and in the case of any Global Security, in accordance with the Applicable Procedures, in minimum denominations of $2,000 or any integral multiples of $1,000 in excess thereof. The Trustee will notify the
Company promptly of the 2027 Notes or portions of 2027 Notes to be called for redemption. Notice of redemption must be sent by the Company or at the Company’s request, by the Trustee by first class mail or, with respect to any Global Security,
the Applicable Procedures, in the name and at the expense of the Company, to Holders whose 2027 Notes are to be redeemed at least 10 days but not more than 60 days before the redemption date. 

  
 13 

	 	(vi)	 The notice of redemption will identify the 2027 Notes to be redeemed and will include or state the following:

  

	 	a.	 the redemption date; 

 

	 	b.	 the redemption price, including the portion thereof representing any accrued interest; 

 

	 	c.	 the place or places where 2027 Notes are to be surrendered for redemption; 

 

	 	d.	 2027 Notes called for redemption must be so surrendered in order to collect the redemption price;

  

	 	e.	 on the redemption date the redemption price will become due and payable on 2027 Notes called for redemption,
and interest on 2027 Notes called for redemption will cease to accrue on and after the redemption date; 

  

	 	f.	 if any 2027 Note is redeemed in part, on and after the redemption date, upon surrender of such 2027 Note, new
2027 Notes equal in principal amount to the unredeemed portion will be issued; and 

  

	 	g.	 if any Note contains a CUSIP, ISIN, or CINS number, no representation is being made as to the correctness of
the CUSIP, ISIN, or CINS number either as printed on the 2027 Notes or as contained in the notice of redemption and that the Holder should rely only on the other identification numbers printed on the 2027 Notes. 

 

	 	(vii)	 Once notice of redemption is sent to the Holders, 2027 Notes called for redemption become due and payable at
the redemption price on the redemption date, and upon surrender of the 2027 Notes called for redemption, the Company shall redeem such 2027 Notes at the redemption price. Unless the Company defaults in the payment of the redemption price, commencing
on the redemption date 2027 Notes redeemed will cease to accrue interest. Upon surrender of any Note redeemed in part, the Holder will receive a new Note equal in principal amount to the unredeemed portion of the surrendered Note. The principal
amount after redemption in part shall be in minimum denominations of $2,000 or any integral multiple of $1,000 in excess thereof. 

  

	 	(h)	 Sinking Fund. There shall be no sinking fund for the 2027 Notes. 

 

	 	(i)	 Denomination. The 2027 Notes and any beneficial interest in the 2027 Notes shall be in minimum
denominations of $2,000 or any integral multiples of $1,000 in excess thereof. 

  
 14 

	 	(j)	 Index. Payment of interest on the 2027 Notes will not be determined with reference to any index or
formula. 

  

	 	(k)	 Currency of the 2027 Notes. The 2027 Notes shall be denominated, and payment of principal and interest
of the 2027 Notes shall be payable in, the currency of the United States of America. 

  

	 	(l)	 Currency of Payment. The principal of and interest on the 2027 Notes shall be payable in the
currency of the United States of America. 

  

	 	(m)	 Acceleration. 100% of the principal amount of the 2027 Notes shall be payable upon acceleration
(whether automatic or by declaration) of the maturity thereof. 

  

	 	(n)	 [Reserved.] 

  

	 	(o)	 Defeasance. Article 13 of the Base Indenture shall apply to the 2027 Notes. 

 

	 	(p)	 Registered Form. The 2027 Notes shall be issuable as registered Global Securities, and the depositary
for the 2027 Notes shall be the Depository Trust Company, a New York Corporation (“DTC”), or any successor depositary appointed by the Company within 90 days of the termination of services of DTC (or any successor to DTC). Sections 204 and
305 of the Base Indenture shall apply to the 2027 Notes. 

  

	 	(q)	 Events of Default. The Events of Default provided for in Section 501 of the Base Indenture shall
apply to the 2027 Notes, provided that the text of clauses (6) and (7) of Section 501 shall be substituted with the following: 

“(6) (A) the entry by a court having jurisdiction in the premises of (i) a decree or order for relief in respect of
the Company or any Principal Subsidiary Bank in an involuntary case or proceeding under any applicable Federal or State bankruptcy, insolvency, reorganization or other similar law, (ii) a decree or order adjudging the Company or any Principal
Subsidiary Bank bankrupt or insolvent, or approving as properly filed a petition seeking reorganization, arrangement, adjustment or composition of or in respect of the Company or any Principal Subsidiary Bank under any applicable Federal or State
law, or appointing a custodian, receiver, liquidator, assignee, trustee, sequestrator or other similar official of the Company or any Principal Subsidiary Bank or of any substantial part of its property, or ordering the winding up or liquidation of
its affairs, and, in the case of each of (A)(i) and (ii), the continuance of any such decree or order for relief or any such other decree or order unstayed and in effect for a period of 60 consecutive days, (B) the appointment of the Federal
Deposit Insurance Corporation as receiver or conservator of any Principal Subsidiary Bank or any substantial part of the property of the Company or any Principal Subsidiary Bank pursuant to the Federal Deposit Insurance Act, as amended, or
(C) the appointment of the Federal Deposit Insurance Corporation, the Securities Investment Protection Corporation, other Federal or State agency or other person 

  
 15 

 
as receiver or trustee of the Company or any Principal Subsidiary Bank or of any substantial part of the property of the Company or any Principal Subsidiary Bank pursuant to Title II of the
Dodd-Frank Act or SIPA; or 
 (7) the commencement by the Company or any Principal Subsidiary Bank of a voluntary case or
proceeding under any applicable Federal or State bankruptcy, insolvency, reorganization or other similar law or of any other case or proceeding to be adjudicated a bankrupt or insolvent, or the consent by it to the entry of a decree or order for
relief in respect of the Company or any Principal Subsidiary Bank in an involuntary case or proceeding under any applicable Federal or State bankruptcy, insolvency, reorganization or other similar law or to the commencement of any bankruptcy or
insolvency case or proceeding against it, or the filing by it of a petition or answer or consent seeking reorganization or relief under any applicable Federal or State law, or the consent by it to the filing of such petition or to the appointment of
or taking possession by a custodian, receiver, liquidator, conservator, assignee, trustee, sequestrator or other similar official of the Company or any Principal Subsidiary Bank or of any substantial part of its property, including pursuant to the
Federal Deposit Insurance Act or SIPA, or the making by it of an assignment for the benefit of creditors, or the admission by it in writing of its inability to pay its debts generally as they become due, or the taking of corporate action by the
Company or any Principal Subsidiary Bank in furtherance of any such action; or” 
  

	 	(r)	 Covenants. The covenants set forth in Article 10 of the Base Indenture shall apply to the 2027 Notes.

  

	 	(s)	 Additional Terms. Other terms applicable to the 2027 Notes are as otherwise provided for in the
Base Indenture, as supplemented by this Tenth Supplemental Indenture. 

  

	 	(t)	 Day Count Convention. Interest on the 2027 Notes shall be computed on the basis of a 360-day year comprised of twelve 30-day months. 

Section 3.4 
 ARTICLE 4 

Supplemental Indentures 

Section 4.1 Supplemental Indentures. The following paragraph shall be added to the end of Section 901 of the Base
Indenture and shall only apply to the Notes: 
 Notwithstanding the foregoing, without the consent of any Holder of Securities, the Company
and the Trustee may amend or supplement the Indenture or the Securities to conform the terms of the Indenture and the Securities to the description of the Securities in the prospectus supplement dated April 30, 2020 relating to the offering
of the Securities. 

  
 16 

 ARTICLE 5 

Miscellaneous 

Section 5.1 Trust Indenture Act of 1939. This Tenth Supplemental Indenture shall incorporate and be governed by the
provisions of the Trust Indenture Act that are required to be part of and to govern indentures qualified under the Trust Indenture Act. 

Section 5.2 Governing Law. The laws of the State of New York shall govern this Tenth Supplemental Indenture and the
Notes. 
 Section 5.3 Duplicate Originals. The parties may sign any number of copies of this Tenth Supplemental
Indenture. Each signed copy shall be an original, but all of them together represent the same agreement. 
 Section 5.4 Legal
Holidays. Section 113 of the Base Indenture shall be deleted and shall be of no effect with respect to the Notes. The Business Day Convention shall apply. 

Section 5.5 Separability. In case any provision in this Tenth Supplemental Indenture or the Notes shall be invalid,
illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

Section 5.6 Ratification. The Base Indenture, as supplemented and amended by this Tenth Supplemental Indenture, is in
all respects ratified and confirmed. The Base Indenture and this Tenth Supplemental Indenture shall be read, taken and construed as one and the same instrument. All provisions included in this Tenth Supplemental Indenture supersede any conflicting
provisions included in the Base Indenture unless not permitted by law. The Trustee accepts the trusts created by the Base Indenture, as supplemented by this Tenth Supplemental Indenture, and agrees to perform the same upon the terms and conditions
of the Base Indenture, as supplemented by this Tenth Supplemental Indenture. 
 Section 5.7 Effectiveness. The
provisions of this Tenth Supplemental Indenture shall become effective as of the date hereof. 
 Section 5.8
Successors. All agreements of the Company in this Tenth Supplemental Indenture shall bind its successors. All agreements of the Trustee in this Tenth Supplemental Indenture shall bind its successors. 

Section 5.9 Trustee’s Disclaimer. The recitals contained herein shall be taken as the statements of
the Company and the Trustee assumes no responsibility for their correctness. The Trustee shall not be responsible in any manner whatsoever for or in respect of the validity or sufficiency of this Tenth Supplemental Indenture, the Notes, or for or in
respect of the recitals contained herein, all of which recitals are made solely by the Company. 
 [Remainder of page intentionally left
blank.] 

  
 17 

 IN WITNESS WHEREOF, the parties hereto have caused this Tenth Supplemental Indenture to be
duly executed as of the date first above written. 
  

			
	 FIFTH THIRD BANCORP
 as
the Company

		
	By:	 	 /s/ Tayfun Tuzun

	Name:	 	Tayfun Tuzun
	Title:	 	Executive Vice President and Chief Financial Officer

  

			
	Attest:	 	
		
	By:	 	 /s/ H. Samuel Lind

	Name:	 	H. Samuel Lind
	Title: 	 	Senior Vice President, Associate General Counsel, and Assistant Secretary

 [Signature Page to Tenth Supplemental Indenture] 

  
 18 

 
			
	 WILMINGTON TRUST COMPANY

as Trustee

		
	By:	 	 /s/ Michael H. Wass

	Name:	 	Michael H. Wass
	Title:	 	Vice President

 [Signature Page to Tenth Supplemental Indenture] 

  
 19 

 EXHIBIT A 

[FORM OF 2023 NOTE] 

 CUSIP No. 316773 CZ1 

ISIN: US316773CZ10 
 THIS SECURITY IS A
GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS
SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

BY ITS ACQUISITION AND HOLDING OF THIS NOTE, THE HOLDER HEREOF (OR ANY INTEREST THEREIN) SHALL BE DEEMED TO HAVE REPRESENTED AND WARRANTED THAT IT IS NOT, AND
IS NOT ACTING ON BEHALF OF, AND NO PORTION OF THE ASSETS USED BY SUCH HOLDER TO ACQUIRE OR HOLD THIS NOTE CONSTITUTES THE ASSETS OF AN EMPLOYEE BENEFIT PLAN THAT IS SUBJECT TO TITLE I OF THE U.S. EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974, AS
AMENDED (“ERISA”), OF A PLAN, INDIVIDUAL RETIREMENT ACCOUNT OR OTHER ARRANGEMENT THAT IS SUBJECT TO SECTION 4975 OF THE U.S. INTERNAL REVENUE CODE OF 1986, AS AMENDED (THE “CODE”) (EACH A “PLAN”) OR PROVISIONS UNDER ANY
OTHER FEDERAL, STATE, LOCAL, NON-U.S. OR OTHER LAWS OR REGULATIONS THAT ARE SIMILAR TO SECTION 406 OF ERISA OR SECTION 4975 OF THE CODE (“SIMILAR LAWS”), OR OF AN ENTITY WHOSE UNDERLYING ASSETS ARE
CONSIDERED TO INCLUDE “PLAN ASSETS” OF ANY SUCH PLAN, ACCOUNT OR ARRANGEMENT (ALSO A “PLAN”), OR (2) THE ACQUISITION AND HOLDING OF THIS NOTE WILL NOT CONSTITUTE A NON-EXEMPT
PROHIBITED TRANSACTION UNDER SECTION 406 OF ERISA OR SECTION 4975 OF THE CODE OR A SIMILAR VIOLATION UNDER ANY APPLICABLE SIMILAR LAWS. 
 ADDITIONALLY, BY
ITS ACQUISITION OF THIS NOTE IN THE INITIAL OFFERING, A HOLDER HEREOF THAT IS A PLAN (THE “PLAN FIDUCIARY”) SHALL BE DEEMED TO HAVE REPRESENTED AND WARRANTED AT ALL TIMES NEITHER FIFTH THIRD BANCORP, THE UNDERWRITERS, NOR ANY OF THEIR
RESPECTIVE AFFILIATES HAS PROVIDED OR WILL PROVIDE IMPARTIAL INVESTMENT ADVICE OR GIVE ADVICE IN A FIDUCIARY CAPACITY WITH RESPECT TO THE PURCHASER OR TRANSFEREE’S DECISION TO ACQUIRE, HOLD, SELL, EXCHANGE, VOTE OR PROVIDE ANY CONSENT WITH
RESPECT TO THE NOTES BY THE ERISA PLAN’S FIDUCIARY (WITHIN THE MEANING OF ERISA OR THE CODE). 
 UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED
REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO FIFTH THIRD BANCORP OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE, OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE &
CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE, OR OTHER USE
HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 

 FIFTH THIRD BANCORP 

1.625% Senior Notes due 2023 
 THIS
SECURITY IS NOT A DEPOSIT AND IS NOT INSURED BY THE FEDERAL DEPOSIT INSURANCE CORPORATION, THE DEPOSIT INSURANCE FUND OR ANY OTHER GOVERNMENTAL AGENCY, NOR IS IT AN OBLIGATION OF, OR GUARANTEED BY, A BANK. 

 

			
	No. 1	  	$500,000,000

 Fifth Third Bancorp, a corporation duly organized and existing under the laws of Ohio (herein called the
“Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to CEDE & CO., or registered assigns, the principal sum of Five Hundred Million
Dollars ($500,000,000) on May 5, 2023 (the “Maturity Date”), and to pay interest thereon from May 5, 2020 (the “Original Issue Date”) or from the most recent Interest Payment Date to which interest has been paid or
duly provided for, semi-annually on May 5 and November 5 each year, commencing November 5, 2020, at the rate of 1.625% per annum, until the principal hereof is paid or made available for payment, provided that any
principal and premium, and any such installment of interest, which is overdue shall bear interest at the rate of 1.625% per annum (to the extent that the payment of such interest shall be legally enforceable), from the dates such amounts are
due until they are paid or made available for payment, and such interest shall be payable on demand. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the
Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be April 20 or October 21 (whether or not a Business Day),
as the case may be, next preceding such Interest Payment Date. “Business Day” means any day that is not a Saturday or Sunday, and that is not a day on which banking institutions in the City of New York are authorized or obligated by law,
regulation or executive order to close. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or
one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less
than 10 days prior to such Special Record Date, or 

 
be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may
be required by such exchange, all as more fully provided in said Indenture. 
 Payment of the principal of (and premium, if any) and
interest on this Security will be made at the office or agency of the Company maintained for that purpose in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts;
provided, however, that at the option of the Company payment of interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register. The Company shall make, or cause
the Paying Agent to make, all payments of principal and interest on Global Securities in immediately available funds to the Depositary or its nominee, in accordance with Applicable Procedures. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 Unless the certificate of authentication hereon has been executed by the
Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

							
	Dated:             , 2020	 		 	FIFTH THIRD BANCORP
				
		 		 	By:	 	  

		 		 		 	Tayfun Tuzun
		 		 		 	Executive Vice President and Chief Financial Officer

  

					
	Attest:
		
	By:	 	  

		 	Name:	 	H. Samuel Lind
		 	Title:	 	Senior Vice President, Associate General Counsel and Assistant Secretary

 [Signature Page to Note] 

 CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the Indenture referred to hereinafter. 

 

							
	Dated: May             , 2020	 		 	WILMINGTON TRUST COMPANY, as Trustee
				
		 		 	By:	 	  

		 		 		 	Authorized Officer

 [Reverse of Security] 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities” or
“Notes”), issued and to be issued in one or more series under an Indenture, dated as of April 30, 2008 (herein called the “Base Indenture”, which term shall have the meaning assigned to it in such instrument),
between the Company and Wilmington Trust Company, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture) as supplemented by a Tenth Supplemental Indenture, dated as of May 5, 2020,
between the Company and the Trustee (herein called the “Tenth Supplemental Indenture” and together with the Base Indenture, the “Indenture”), and reference is hereby made to the Indenture for a statement of
the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is
one of the series designated on the face hereof. The Company may, without notice to or the consent of any Holder, issue additional Securities having the same ranking, interest rate, maturity and other terms as the Securities of this series except
for the issue date, the issue price and the initial Interest Payment Date, provided that if such additional Securities are not fungible with this Security for U.S. federal income tax purposes, such additional Securities will be issued with a
separate CUSIP number. Any such additional Securities may be considered to be part of this series of Securities. The Company may, without notice to or the consent of any Holder, issue or incur Senior Indebtedness. 

The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and
Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 
 If an
Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable (or will automatically become due and payable, without declaration or any other
action on the part of the Trustee or any Holder) in the manner and with the effect provided in the Indenture. 
 The Securities will be
redeemable at the Company’s option, in whole or in part, at any time or from time to time, on or after November 2, 2020, and prior to the Applicable Par Call Date (as defined below), in each case at a redemption price, plus accrued and
unpaid interest thereon, if any, to, but excluding, the redemption date, equal to the greater of: 
  

	 	•	 	 100% of the aggregate principal amount of the Securities being redeemed on that redemption date; and

  

	 	•	 	 the sum of the present values of the remaining scheduled payments of principal and interest on the Securities
being redeemed that would be due if the Securities to be redeemed matured on the Applicable Par Call Date (not including any portion of such payments of interest accrued to the redemption date) discounted to the redemption date on a semi-annual
basis (assuming a 360-day year consisting of twelve 30-day months) at the applicable Treasury Rate plus the Applicable Spread for the Securities to be redeemed. The
Trustee 

	 	 
(including in its capacity as Paying Agent), shall have no responsibility to calculate any amounts in this bullet point and shall be entitled to conclusively rely upon calculation thereof as
provided by the Company to the Trustee and Paying Agent. 

 “Applicable Par Call Date means April 5, 2023. 

“Applicable Spread” means 25 basis points. 

“Comparable Treasury Issue” means the United States Treasury security selected by an Independent Investment Banker as having an
actual or interpolated maturity comparable to the remaining term of the Securities to be redeemed (assuming the Securities matured on the Applicable Par Call Date) that would be utilized, at the time of selection and in accordance with customary
financial practice, in pricing new issues of corporate debt securities of comparable maturity to such remaining term. 
 “Comparable
Treasury Price” means, with respect to any redemption date for Securities to be redeemed, (A) if the Independent Investment Banker obtains four or more applicable Reference Treasury Dealer Quotations, the average of all such Reference
Treasury Dealer Quotations after excluding the highest and lowest of such applicable Reference Treasury Dealer Quotations or (B) if the Independent Investment Banker obtains fewer than four applicable Reference Treasury Dealer Quotations, the
average of all such Reference Treasury Dealer Quotations. 
 “Independent Investment Banker” means one of the Reference Treasury
Dealers appointed by the Company to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealers” mean,
with respect to the Securities offered hereby, (A), Morgan Stanley & Co. LLC, Fifth Third Securities, Inc., J.P. Morgan Securities LLC, and RBC Capital Markets, LLC (or their respective affiliates which are Primary Treasury Dealers
(as defined below)), and their respective successors; provided, however, that if any of the foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will
substitute therefor another Primary Treasury Dealer; and (B) any other Primary Treasury Dealer(s) selected by us. 
 “Reference
Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and any redemption date for Securities to be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the
Comparable Treasury Issue for the Securities to be redeemed on such redemption date (expressed in each case as a percentage of its aggregate principal amount) quoted in writing to the Independent Investment Banker by such Reference Treasury Dealer
at 5:00 p.m. (New York City time) on the third business day preceding such redemption date. As used in the preceding sentence, “business day” means any day (other than a Saturday or Sunday) on which banking institutions in the City of New
York are not authorized or obligated by law or executive order to remain closed. 

 “Treasury Rate” means, with respect to any redemption date applicable to the
Securities, the rate per annum equal to the semi-annual equivalent yield to maturity of the Comparable Treasury Issue for the Securities to be redeemed on such redemption date, assuming a price for the Comparable Treasury Issue (expressed as a
percentage of its aggregate principal amount) equal to the applicable Comparable Treasury Price for such redemption date. 
 On and after
the Applicable Par Call Date, the Securities will be redeemable, in whole or in part, at any time and from time to time, at the Company’s option at a redemption price equal to 100% of the aggregate principal amount of the Securities being
redeemed, plus accrued and unpaid interest thereon, if any, to, but excluding, the redemption date. 
 Installments of interest whose Stated
Maturity is on or prior to the Redemption Date will be payable to the Holder of this Security, or one more Predecessor Securities, of record at the close of business on the relevant Record Date, all as provided in the Indenture. 

Notice of redemption will be given by first class mail to Holders of Securities, not less than 10 nor more than 60 days prior to the
redemption date, all as provided in the Tenth Supplemental Indenture. 
 This Security may be redeemed in part only in minimum denominations
of $2,000 or any integral multiples of $1,000 in excess thereof. In the event of redemption of this Security in part only, a new Security or Securities for the unredeemed portion hereof shall be issued in the name of the Holder hereof upon the
cancellation hereof. 
 The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of
the rights and obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in principal amount
of the Securities at the time Outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities of each series at the time Outstanding, on behalf
of the Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this
Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such
consent or waiver is made upon this Security. Notwithstanding the foregoing, without the consent of any Holder of Securities, the Company and the Trustee may amend or supplement the Indenture or the Securities to conform to the terms of the
Indenture and the Securities to the description of the Securities in the prospectus supplement dated April 30, 2020 relating to the offering of the Securities. 

As provided in and subject to the provisions of the Indenture, the Holder of this Security shall not have the right to institute any
proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder, unless such Holder shall have previously given the Trustee written notice of a continuing Event of Default with respect to
the Securities of this series, the Holders of not less than 25% in principal amount of 

 
the Securities of this series at the time Outstanding shall have made written request to the Trustee to institute proceedings in respect of such Event of Default as Trustee and offered the
Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of a majority in principal amount of Securities of this series at the time Outstanding a direction inconsistent with such request, and shall have failed to
institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this Security for the enforcement of any payment of principal hereof or
any premium or interest hereon on or after the respective due dates expressed herein. 
 No reference herein to the Indenture and no
provision of this Security or of the Indenture shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the
coin or currency, herein prescribed. 
 As provided in the Indenture and subject to certain limitations therein set forth, the transfer of
this Security is registrable in the Security Register, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Security are payable,
duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new
Securities of this series and of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Securities of this series are issuable only in registered form without coupons in minimum denominations of $2,000 or any integral
multiples of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor
of a different authorized denomination, as requested by the Holder surrendering the same. 
 No service charge shall be made for any such
registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 

All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture. 

 EXHIBIT B 

[FORM OF 2027 NOTE] 

CUSIP No. 316773 DA5 

ISIN: US316773DA59 
 THIS SECURITY IS A
GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF A DEPOSITARY OR A NOMINEE THEREOF. THIS SECURITY MAY NOT BE EXCHANGED IN WHOLE OR IN PART FOR A SECURITY REGISTERED, AND NO TRANSFER OF THIS
SECURITY IN WHOLE OR IN PART MAY BE REGISTERED, IN THE NAME OF ANY PERSON OTHER THAN SUCH DEPOSITARY OR A NOMINEE THEREOF, EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE. 

BY ITS ACQUISITION AND HOLDING OF THIS NOTE, THE HOLDER HEREOF (OR ANY INTEREST THEREIN) SHALL BE DEEMED TO HAVE REPRESENTED AND WARRANTED THAT IT IS NOT, AND
IS NOT ACTING ON BEHALF OF, AND NO PORTION OF THE ASSETS USED BY SUCH HOLDER TO ACQUIRE OR HOLD THIS NOTE CONSTITUTES THE ASSETS OF AN EMPLOYEE BENEFIT PLAN THAT IS SUBJECT TO TITLE I OF THE U.S. EMPLOYEE RETIREMENT INCOME SECURITY ACT OF 1974, AS
AMENDED (“ERISA”), OF A PLAN, INDIVIDUAL RETIREMENT ACCOUNT OR OTHER ARRANGEMENT THAT IS SUBJECT TO SECTION 4975 OF THE U.S. INTERNAL REVENUE CODE OF 1986, AS AMENDED (THE “CODE”) (EACH A “PLAN”) OR PROVISIONS UNDER ANY
OTHER FEDERAL, STATE, LOCAL, NON-U.S. OR OTHER LAWS OR REGULATIONS THAT ARE SIMILAR TO SECTION 406 OF ERISA OR SECTION 4975 OF THE CODE (“SIMILAR LAWS”), OR OF AN ENTITY WHOSE UNDERLYING ASSETS ARE
CONSIDERED TO INCLUDE “PLAN ASSETS” OF ANY SUCH PLAN, ACCOUNT OR ARRANGEMENT (ALSO A “PLAN”), OR (2) THE ACQUISITION AND HOLDING OF THIS NOTE WILL NOT CONSTITUTE A NON-EXEMPT
PROHIBITED TRANSACTION UNDER SECTION 406 OF ERISA OR SECTION 4975 OF THE CODE OR A SIMILAR VIOLATION UNDER ANY APPLICABLE SIMILAR LAWS. 
 ADDITIONALLY, BY
ITS ACQUISITION OF THIS NOTE IN THE INITIAL OFFERING, A HOLDER HEREOF THAT IS A PLAN (THE “PLAN FIDUCIARY”) SHALL BE DEEMED TO HAVE REPRESENTED AND WARRANTED AT ALL TIMES NEITHER FIFTH THIRD BANCORP, THE UNDERWRITERS, NOR ANY OF THEIR
RESPECTIVE AFFILIATES HAS PROVIDED OR WILL PROVIDE IMPARTIAL INVESTMENT ADVICE OR GIVE ADVICE IN A FIDUCIARY CAPACITY WITH RESPECT TO THE PURCHASER OR TRANSFEREE’S DECISION TO ACQUIRE, HOLD, SELL, EXCHANGE, VOTE OR PROVIDE ANY CONSENT WITH
RESPECT TO THE NOTES BY THE ERISA PLAN’S FIDUCIARY (WITHIN THE MEANING OF ERISA OR THE CODE). 
 UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED
REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO FIFTH THIRD BANCORP OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE, OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE &
CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE, OR OTHER USE HEREOF
FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 

 FIFTH THIRD BANCORP 

2.550% Senior Notes due 2027 
 THIS
SECURITY IS NOT A DEPOSIT AND IS NOT INSURED BY THE FEDERAL DEPOSIT INSURANCE CORPORATION, THE DEPOSIT INSURANCE FUND OR ANY OTHER GOVERNMENTAL AGENCY, NOR IS IT AN OBLIGATION OF, OR GUARANTEED BY, A BANK. 

 

			
	No. 1	  	$500,000,000

 Fifth Third Bancorp, a corporation duly organized and existing under the laws of Ohio (herein called the
“Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to CEDE & CO., or registered assigns, the principal sum of Five Hundred Million
Dollars ($500,000,000) on May 5, 2027 (the “Maturity Date”), and to pay interest thereon from May 5, 2020 (the “Original Issue Date”) or from the most recent Interest Payment Date to which interest has been paid or
duly provided for, semi-annually on May 5 and November 5 each year, commencing November 5, 2020, at the rate of 2.550% per annum, until the principal hereof is paid or made available for payment, provided that any
principal and premium, and any such installment of interest, which is overdue shall bear interest at the rate of 2.550% per annum (to the extent that the payment of such interest shall be legally enforceable), from the dates such amounts are
due until they are paid or made available for payment, and such interest shall be payable on demand. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the
Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be April 20 or October 21 (whether or not a Business Day),
as the case may be, next preceding such Interest Payment Date. “Business Day” means any day that is not a Saturday or Sunday, and that is not a day on which banking institutions in the City of New York are authorized or obligated by law,
regulation or executive order to close. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security (or
one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holders of Securities of this series not less
than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as may be
required by such exchange, all as more fully provided in said Indenture. 

 Payment of the principal of (and premium, if any) and interest on this Security will be made
at the office or agency of the Company maintained for that purpose in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts; provided, however, that at
the option of the Company payment of interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register. The Company shall make, or cause the Paying Agent to make, all payments of
principal and interest on Global Securities in immediately available funds to the Depositary or its nominee, in accordance with Applicable Procedures. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for all
purposes have the same effect as if set forth at this place. 
 Unless the certificate of authentication hereon has been executed by the
Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

							
	Dated:             , 2020	 		 	FIFTH THIRD BANCORP
				
		 		 	By:	 	
                     
                    

		 		 		 	Tayfun Tuzun
		 		 		 	Executive Vice President and Chief Financial Officer

  

					
	Attest:
		
	By:	 	  

		 	Name:	 	H. Samuel Lind
		 	Title:	 	Senior Vice President, Associate General Counsel and Assistant Secretary

 [Signature Page to Note] 

 CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the Indenture referred to hereinafter. 

 

							
	Dated: May     , 2020	 		 	WILMINGTON TRUST COMPANY, as Trustee
				
		 		 	By:	 	
                     
                    

		 		 		 	Authorized Officer

 [Reverse of Security] 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities” or
“Notes”), issued and to be issued in one or more series under an Indenture, dated as of April 30, 2008 (herein called the “Base Indenture”, which term shall have the meaning assigned to it in such instrument),
between the Company and Wilmington Trust Company, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture) as supplemented by a Tenth Supplemental Indenture, dated as of May 5, 2020,
between the Company and the Trustee (herein called the “Tenth Supplemental Indenture” and together with the Base Indenture, the “Indenture”), and reference is hereby made to the Indenture for a statement of
the respective rights, limitations of rights, duties and immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is
one of the series designated on the face hereof. The Company may, without notice to or the consent of any Holder, issue additional Securities having the same ranking, interest rate, maturity and other terms as the Securities of this series except
for the issue date, the issue price and the initial Interest Payment Date, provided that if such additional Securities are not fungible with this Security for U.S. federal income tax purposes, such additional Securities will be issued with a
separate CUSIP number. Any such additional Securities may be considered to be part of this series of Securities. The Company may, without notice to or the consent of any Holder, issue or incur Senior Indebtedness. 

The Indenture contains provisions for defeasance at any time of the entire indebtedness of this Security or certain restrictive covenants and
Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 
 If an
Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable (or will automatically become due and payable, without declaration or any other
action on the part of the Trustee or any Holder) in the manner and with the effect provided in the Indenture. 
 The Securities will be
redeemable at the Company’s option, in whole or in part, at any time or from time to time, on or after November 2, 2020, and prior to the Applicable Par Call Date (as defined below), in each case at a redemption price, plus accrued and
unpaid interest thereon, if any, to, but excluding, the redemption date, equal to the greater of: 
  

	 	•	 	 100% of the aggregate principal amount of the Securities being redeemed on that redemption date; and

  

	 	•	 	 the sum of the present values of the remaining scheduled payments of principal and interest on the Securities
being redeemed that would be due if the Securities to be redeemed matured on the Applicable Par Call Date (not including any portion of such payments of interest accrued to the redemption date) discounted to the redemption date on a semi-annual
basis (assuming a 360-day year consisting of twelve 30-day months) at the applicable Treasury Rate plus the Applicable Spread for the Securities to be redeemed. The
Trustee 

	 	 
(including in its capacity as Paying Agent), shall have no responsibility to calculate any amounts in this bullet point and shall be entitled to conclusively rely upon calculation thereof as
provided by the Company to the Trustee and Paying Agent. 

 “Applicable Par Call Date means April 5, 2027. 

“Applicable Spread” means 35 basis points. 

“Comparable Treasury Issue” means the United States Treasury security selected by an Independent Investment Banker as having an
actual or interpolated maturity comparable to the remaining term of the Securities to be redeemed (assuming the Securities matured on the Applicable Par Call Date) that would be utilized, at the time of selection and in accordance with customary
financial practice, in pricing new issues of corporate debt securities of comparable maturity to such remaining term. 
 “Comparable
Treasury Price” means, with respect to any redemption date for Securities to be redeemed, (A) if the Independent Investment Banker obtains four or more applicable Reference Treasury Dealer Quotations, the average of all such Reference
Treasury Dealer Quotations after excluding the highest and lowest of such applicable Reference Treasury Dealer Quotations or (B) if the Independent Investment Banker obtains fewer than four applicable Reference Treasury Dealer Quotations, the
average of all such Reference Treasury Dealer Quotations. 
 “Independent Investment Banker” means one of the Reference Treasury
Dealers appointed by the Company to act as the “Independent Investment Banker.” 
 “Reference Treasury Dealers” mean,
with respect to the Securities offered hereby, (A), Morgan Stanley & Co. LLC, Fifth Third Securities, Inc., J.P. Morgan Securities LLC, and RBC Capital Markets, LLC (or their respective affiliates which are Primary Treasury Dealers
(as defined below)), and their respective successors; provided, however, that if any of the foregoing shall cease to be a primary U.S. Government securities dealer in the United States (a “Primary Treasury Dealer”), the Company will
substitute therefor another Primary Treasury Dealer; and (B) any other Primary Treasury Dealer(s) selected by us. 
 “Reference
Treasury Dealer Quotation” means, with respect to each Reference Treasury Dealer and any redemption date for Securities to be redeemed, the average, as determined by the Independent Investment Banker, of the bid and asked prices for the
Comparable Treasury Issue for the Securities to be redeemed on such redemption date (expressed in each case as a percentage of its aggregate principal amount) quoted in writing to the Independent Investment Banker by such Reference Treasury Dealer
at 5:00 p.m. (New York City time) on the third business day preceding such redemption date. As used in the preceding sentence, “business day” means any day (other than a Saturday or Sunday) on which banking institutions in the City of New
York are not authorized or obligated by law or executive order to remain closed. 

 “Treasury Rate” means, with respect to any redemption date applicable to the
Securities, the rate per annum equal to the semi-annual equivalent yield to maturity of the Comparable Treasury Issue for the Securities to be redeemed on such redemption date, assuming a price for the Comparable Treasury Issue (expressed as a
percentage of its aggregate principal amount) equal to the applicable Comparable Treasury Price for such redemption date. 
 On and after
the Applicable Par Call Date, the Securities will be redeemable, in whole or in part, at any time and from time to time, at the Company’s option at a redemption price equal to 100% of the aggregate principal amount of the Securities being
redeemed, plus accrued and unpaid interest thereon, if any, to, but excluding, the redemption date. 
 Installments of interest whose Stated
Maturity is on or prior to the Redemption Date will be payable to the Holder of this Security, or one more Predecessor Securities, of record at the close of business on the relevant Record Date, all as provided in the Indenture. 

Notice of redemption will be given by first class mail to Holders of Securities, not less than 10 nor more than 60 days prior to the
redemption date, all as provided in the Tenth Supplemental Indenture. 
 This Security may be redeemed in part only in minimum denominations
of $2,000 or any integral multiples of $1,000 in excess thereof. In the event of redemption of this Security in part only, a new Security or Securities for the unredeemed portion hereof shall be issued in the name of the Holder hereof upon the
cancellation hereof. 
 The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of
the rights and obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in principal amount
of the Securities at the time Outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities of each series at the time Outstanding, on behalf
of the Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this
Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such
consent or waiver is made upon this Security. Notwithstanding the foregoing, without the consent of any Holder of Securities, the Company and the Trustee may amend or supplement the Indenture or the Securities to conform to the terms of the
Indenture and the Securities to the description of the Securities in the prospectus supplement dated April 30, 2020 relating to the offering of the Securities. 

As provided in and subject to the provisions of the Indenture, the Holder of this Security shall not have the right to institute any
proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder, unless such Holder shall have previously given the Trustee written notice of a continuing Event of Default with respect to
the Securities of this series, the Holders of not less than 25% in principal amount of 

 
the Securities of this series at the time Outstanding shall have made written request to the Trustee to institute proceedings in respect of such Event of Default as Trustee and offered the
Trustee reasonable indemnity, and the Trustee shall not have received from the Holders of a majority in principal amount of Securities of this series at the time Outstanding a direction inconsistent with such request, and shall have failed to
institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this Security for the enforcement of any payment of principal hereof or
any premium or interest hereon on or after the respective due dates expressed herein. 
 No reference herein to the Indenture and no
provision of this Security or of the Indenture shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the
coin or currency, herein prescribed. 
 As provided in the Indenture and subject to certain limitations therein set forth, the transfer of
this Security is registrable in the Security Register, upon surrender of this Security for registration of transfer at the office or agency of the Company in any place where the principal of and any premium and interest on this Security are payable,
duly endorsed by, or accompanied by a written instrument of transfer in form satisfactory to the Company and the Security Registrar duly executed by, the Holder hereof or his attorney duly authorized in writing, and thereupon one or more new
Securities of this series and of like tenor, of authorized denominations and for the same aggregate principal amount, will be issued to the designated transferee or transferees. 

The Securities of this series are issuable only in registered form without coupons in minimum denominations of $2,000 or any integral
multiples of $1,000 in excess thereof. As provided in the Indenture and subject to certain limitations therein set forth, Securities of this series are exchangeable for a like aggregate principal amount of Securities of this series and of like tenor
of a different authorized denomination, as requested by the Holder surrendering the same. 
 No service charge shall be made for any such
registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in connection therewith. 

Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee
may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 

All terms used in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture.

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