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Exhibit 10.9  

 
 

ADVANSTAR HOLDINGS CORP.
  Direct Investment Program    
  

        Section 1. Purpose. The purpose of the Advanstar Holdings Corp. Investment Program (the
"Plan") is to promote the interests of Advanstar Holdings Corp. (formerly known as Jetman Acquisition Corp.), a Delaware corporation (the
"Company"), and its stockholders by (i) attracting and retaining exceptional executive personnel and other key employees of the Company and its
Subsidiaries and Affiliates, as defined herein; (ii) aligning the interests of such employees with those of the Company's equity investors; and (iii) enabling such employees to
participate in the long-term growth and financial success of the Company. 

        Section 2.
Definitions. As used in the Plan, the following terms shall have the meanings set forth below: 

        "Affiliate" means, with respect to any Person, any other Person directly or indirectly controlling, controlled by or under common control
with such Person. For purposes of this definition, the terms "control" (including with correlative meanings, the terms
"controlling", "controlled by" and "under common control
with"), when used with respect to any Person, means the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of such
Person, whether through the ownership of voting securities, by contract or otherwise. 

        "Board" shall mean the Board of Directors of the Company. 

        "Cause" means, with respect to any Participant, "cause" as defined in such Participant's Employment Agreement, or if not so defined: 

	(i)
	such
Participant's willful failure to perform his or her material duties (other than as a result of total or partial incapacity due to physical or
mental illness) which such Participant shall have not cured within 30 days of receiving notice of such failure;

	(ii)
	such
Participant's conviction of a felony arising from, or any act of, fraud, embezzlement or willful dishonesty by such Participant in relation to the
business or affairs of the Company and any Subsidiary or Affiliate thereof, or any other felonious conduct on the part of such Participant that is detrimental to the best interests of the Company or
any Subsidiary or Affiliate thereof;

	(iii)
	such
Participant's being repeatedly under the influence of illegal drugs or alcohol while performing his duties; or

	(iv)
	any
other willful misconduct or gross negligence of such Participant which is demonstrably injurious to the financial condition or business reputation 

        of
the Company or any Subsidiary or Affiliate thereof, including such Participant's breach of the provisions of any noncompetition, nonsolicitation or confidentiality covenant (whether
or not contained in this Agreement) in favor of the Company or any Subsidiary or Affiliate thereof binding upon such Participant. 

        "Code" means the Internal Revenue Code of 1986, as amended from time to time. 

        "Committee" means a committee of the Board designated by the Board to administer the Plan. 

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        "Disability" means, with respect to any Participant, "disability" as defined in such Participant's Employment Agreement, or if not so
defined: 

	(i)
	any
permanent physical or mental incapacity or disability rendering such Participant unable or unfit to perform effectively the duties and obligations
of his employment or to participate effectively and actively in the management of the Company (or, if applicable, any Subsidiary or Affiliate thereof); or

	(ii)
	any
illness, accident, injury, physical or mental incapacity or other disability, where such condition has rendered such Participant unable or unfit to
perform effectively the duties and obligations of his or her employment or to participate effectively and actively in the management of the Company, (or, if applicable, any Subsidiary or Affiliate
thereof) for a period of at least 6 consecutive months or 12 months in any 24-month period, (in either case, as determined in good faith judgment of the Committee). 

        "Effective Time" shall have the meaning assigned to it in the Merger Agreement. 

        "Employee" means an employee of the Company or any Subsidiary or Affiliate thereof. 

        "Employment Agreement" means an employment, severance, consulting or similar agreement between the Company or any Subsidiary or Affiliate
thereof and a Participant. 

        "Exchange Act" shall mean the Securities Exchange Act of 1934, as amended from time to time. 

        "Fair Market Value" means: 

	(a)
	as
of the date of the closing of the transactions contemplated by the Merger Agreement (the "Closing Date"), $10.00.

	(b)
	on
any date after the Closing Date, if the Shares are traded on an exchange or market, as of any given date, the average reported closing price of a Share on such exchange or market
as is the principal trading market for such Shares for the three trading days immediately preceding such date; and

	(c)
	on
any date after the Closing Date, if the Shares are not traded on an exchange or market on the applicable date, as determined by the Committee in good faith taking into account as
appropriate recent sales of the Shares, recent valuations of the Shares and such other factors as the Committee shall in its discretion deem relevant or appropriate (excluding a minority discount but
taking into account an Initial Public Offering Discount). 

        "Good Reason" means, with respect to any Participant, "good reason" as defined in such Participant's Employment Agreement, or if not so
defined: 

	(i)
	any
failure by the Company to comply with any of the provisions of this Plan or such Participant's Employment Agreement, other than an insubstantial or
inadvertent failure not occurring in bad faith and which is remedied by the Company promptly after receipt of notice thereof given by such Participant; or

	(ii)
	the
material diminution of such Participant's duties as in effect during the effectiveness of such Participant's Purchase Agreement, excluding an
insubstantial or inadvertent action not taken in bad faith and which is remedied by the Company promptly after receipt of notice thereof given by such Participant. 

        "Initial Public Offering Discount" means a discount to Fair Market Value, as otherwise determined, of the magnitude that would be
necessary, in accordance with usual and customary underwriting market practice, to effect a successful Initial Public Offering (as defined in the Shareholders' Agreement). 

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        "Loan" shall have the meaning set forth in Section 5(c). 

        "Merger Agreement" means the Agreement and Plan of Merger dated as of August 14, 2000, among the Company, Junior Jetman Corp.,
Advanstar Inc. and AHI Advanstar LLC. 

        "Participant" means the individuals listed on Exhibit A hereto (and to the extent applicable, their estates, heirs and
beneficiaries). 

        "Permitted Transferee" shall have the meaning assigned to it in the Shareholders' Agreement. 

        "Person" means any individual, corporation, limited liability company, partnership, association, joint-stock company, trust,
unincorporated organization, government or political subdivision thereof or other entity. 

        "Plan Shares" means any Shares purchased by a Participant under this Plan. 

        "Purchase Agreement" shall mean an agreement to be executed by the Company and a Participant as a condition to the purchase of Shares
under the Plan by such Participant. 

        "Purchase Price" shall have the meaning set forth in Section 5(b). 

        "SEC" shall mean the Securities and Exchange Commission or any successor thereto. 

        "Securities Act" shall mean the Securities Act of 1933, as amended from time to time. 

        "Shares" means (i) shares of common stock, par value $0.01 per share, of the Company and any stock into which its common stock may
thereafter be converted or changed and/or (ii) such other securities as may be designated by the Committee from time to time. 

        "Shareholders' Agreement" means the Shareholders' Agreement dated as of October 11, 2000 among the Company, DLJ Merchant Banking
Partners III, L.P. and other DLJ Funds party thereto, the Existing Shareholders party thereto and the Management Shareholders party thereto. 

        "Subsidiary" means, with respect to any Person, any corporation, limited liability company, partnership, association or other business
entity of which: 

	(i)
	if
a corporation, a majority of the total voting power of shares of stock entitled (without regard to the occurrence of any contingency) to vote in the
election of directors thereof is at the time owned or controlled, directly or indirectly, by that Person or one or more of the Subsidiaries of that Person or a combination thereof; or

	(ii)
	if
a limited liability company, partnership, association or other business entity, a majority of the partnership or other similar ownership interests
thereof is at the time owned or controlled, directly or indirectly, by that Person or one or more Subsidiaries of that Person or a combination thereof. 

        Section 3.
Administration.

	(a)
	Authority
of Committee. The Plan shall be administered by the Committee or by the Board as a whole, if no Committee has been constituted. All references to the powers and
responsibilities of the Committee set forth in this Plan shall be deemed to be references to the Board if no Committee has been constituted. Subject to the terms of the Plan, applicable law and
contractual restrictions affecting the Company, and in addition to other express powers and authorizations conferred on the Committee by the Plan, the Committee shall have full power and authority to:
(i) designate Participants;
(ii) determine the number of Shares to be covered by Purchase Agreements; (iii) determine the terms and conditions of any Purchase Agreement; (iv) determine whether, to what
extent, and under what circumstances Purchase Agreements may be amended or terminated and Shares purchased or otherwise acquired thereunder may be reacquired or transferred; (v) interpret and
administer the Plan and any 

3

 

Purchase
Agreement or other instrument or agreement relating to, or made under, the Plan; (vi) establish, amend, suspend, or waive such rules and regulations and appoint such agents as it
shall deem appropriate for the proper administration of the Plan; and (vii) make any other determination and take any other action that the Committee deems necessary or desirable for the
administration of the Plan. 

	(b)
	Committee
Discretion Binding. Unless otherwise expressly provided in the Plan, all designations, determinations, interpretations, and other decisions under or with respect to the Plan
or any Purchase Agreement shall be within the sole discretion of the Committee, may be made at any time and shall be final, conclusive and binding upon all Persons, including the Company, any
Subsidiary or Affiliate thereof, any Participant, any holder or beneficiary of any Purchase Agreement, any stockholder and any Employee. 

        Section 4.
Shares Available for Purchase under the Plan.

	(a)
	Number
of Shares. Subject to adjustment as provided in Section 4(b), the number of Shares available for purchase under the Plan shall be 1,500,000.

	(b)
	Adjustments.
In the event that the Committee determines that any dividend or other distribution (whether in the form of cash, Shares, other securities or other property),
recapitalization, stock split, reverse stock split, reorganization, reclassification, merger, consolidation, split-up, spin-off, combination, repurchase, or exchange of Shares
or other securities of the Company, issuance of warrants or other rights to purchase Shares or other securities of the Company, or other similar corporate transaction or event affects the Shares such
that an adjustment is determined by the Committee to be appropriate in order to prevent dilution or enlargement of the benefits or potential benefits of a Participant's investment in Shares under the
Plan, then the Committee shall, in such manner as it deems equitable, make such adjustments, if any, to the number and kind of Shares (or number and kind of other securities or property) with respect
to which Purchase Agreements have been or may thereafter be entered into hereunder as it deems appropriate and necessary.

	(c)
	Sources
of Shares. Any Shares delivered pursuant to a Purchase Agreement may be either authorized and unissued Shares, or previously issued Shares, held in the treasury of the
Company. 

        Section 5.
Share Purchases.

	(a)
	Purchase.
The number of Plan Shares set forth opposite each Participant's name in Exhibit A hereto shall be made available for purchase by such Participant, effective as of the
consummation of the transactions contemplated by the Merger Agreement; provided, that Exhibit A may be amended from time to time through
December 31, 2000 to permit new Participants to participate in the Plan.

	(b)
	Purchase
Price. The price at which each Plan Share under the Plan may be purchased by a Participant hereunder (the "Purchase Price")
shall be $10.00 per Share unless agreed otherwise by the Company and Participant.

	(c)
	Payment.
No Shares shall be delivered hereunder until payment in full of the Purchase Price therefor is received by the Company. Such payment may be made in cash or its equivalent,
pursuant to financing arrangements approved by the Committee, including loans to Participants made by the Company in the form of Exhibit B hereto (the
"Loans") of up to the amounts set forth opposite such Participants' names in Exhibit A hereto, or a combination of the foregoing;  provided that the
combined value of all cash, cash equivalents and such financing arrangements, including Loans, is at least equal to such Purchase
Price; and provided  

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 further that payments made pursuant to financing arrangements, including Loans, approved by the Committee shall constitute no more than half of such Purchase Price. 

        Section 6.
Vesting. The Plan Shares purchased by any Participant shall be fully vested, subject to the Company's rights under
Section 8. 

        Section 7.  Rollover Shares. Management who own shares of Advanstar, Inc. may rollover such shares (the
"Rollover Shares") for newly issued Shares of the Company pursuant to the Subscription and Contribution Agreement dated as of October 11, 2000
among the Company, DLJ Merchant Banking Partners III, L.P., the Other DLJ Funds Party thereto, Robert L. Krakoff and James M. Alic. 

        Section 8.
Termination of Employment; Repayment of Loan; Repurchase Rights. Except as may be set forth in any Purchase Agreement or
as otherwise determined by the Committee at any time, upon the termination of a Participant's employment with the Company or a Subsidiary or Affiliate thereof: 

	(a)
	Any
outstanding Loan shall become due in accordance with the terms of such Loan.

	(b)
	If
the Participant's employment with the Company or a Subsidiary thereof is terminated (x) by the Company or a Subsidiary or an Affiliate thereof without Cause or (y) 
by the Participant for Good
Reason, then the Company or its designee shall have the option and right to repurchase all or a portion of the Plan Shares and the Rollover Shares held by the Participant or his or her Permitted
Transferee (the "Call Right"), at a price per Share equal to the Fair Market Value of such Plan Shares or such Rollover Shares, as the case may be, on
the date of termination.

	(c)
	If
the Participant's employment with the Company or a Subsidiary or Affiliate thereof is terminated by the Company or a Subsidiary or Affiliate thereof for Cause, then the Plan Shares
and Rollover Shares shall be subject to the Call Right at a price equal to the lower of the Purchase Price with respect to such Plan Shares or the cost with respect to such Rollover Shares, as the
case may be, or the Fair Market Value of such Plan Shares or Rollover Shares, as the case may be, on the date of termination. For purposes of this Section 8(d), the cost of Rollover Shares
shall be deemed to be $10.00 per share.

	(d)
	If
the Participant's employment with the Company or a Subsidiary thereof shall terminate due to death, disability or Qualified Retirement (as defined below), then the Plan Shares and
the Rollover Shares shall be subject to the Call Right at a price equal to the Fair Market Value of such Plan Shares or Rollover Shares, as the case may be, on the date of termination. In addition,
the Participant has the right to sell the Plan Shares and the Rollover Shares to the Company (the "Put Right") at a price equal to the Fair Market Value
of the Plan Shares or the Rollover Shares, as the case may be, on the date of termination. "Qualified Retirement" means retirement at age 62 (except in
the case of Robert Krakoff or James Alic) or with Board approval.

	(e)
	If
the Participant's employment with the Company or a Subsidiary thereof is terminated by the Participant without Good Reason, then the Plan Shares and the Rollover Shares shall be
subject to the Call Right at a price equal to the Adjusted Fair Market Value (as defined below). 

        "Adjusted Fair Market Value" means the Fair Market Value of a Share, (assuming no discount for minority interest but reflecting an Initial
Public Offering Discount) reduced by (A) the amount by which (1) such Fair Market Value exceeds (2) the Exercise Price paid for such Shares multiplied by (B)(1) 20% if the
Participant's termination of employment occurs prior to the first anniversary of the Effective Time, (2) 15% if the Participant's termination of employment occurs between the first and second
anniversary of the Effective Time, (3) 10% if the Participant's termination of Employment occurs between the second and third anniversary of the Effective Time, (4) 5% if the
Participant's 

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termination of employment occurs after the third anniversary but prior to the fourth anniversary of the Effective Time and (5) 0% if the Participant's termination of employment occurs on or
after the fourth anniversary of the Effective Time. 

	(f)
	If
the Company elects to exercise its Call Right under this Section 8, the Company shall deliver written notice (a "Purchase
Notice") to the Participant to such effect within 90 days after the occurrence of the applicable event of termination which shall specify the date for the closing of the
transaction, which shall be no more than 30 days nor less than 5 days after delivery of the Purchase
Notice. For purposes of this Section 8, the "date of purchase" shall mean the date of closing of the transaction specified in the Purchase Notice
from the Company. The proceeds of any Plan Shares or Rollover Shares purchased from a Participant (or his or her Permitted Transferee) pursuant to this Section 8 shall be applied first to the
amount of any interest and principal outstanding under any Loans owed by such Participant and secured by such Plan Shares or Rollover Shares, as the case may be, in accordance with the terms of such
Loans. Any excess proceeds remaining after repayment of all such interest and principal shall be paid to such Participant (or his or her Permitted Transferee) in cash or by certified check;  provided
that if the terms of any agreement to which the Company is a party, or any of the indentures governing any debt securities issued by the
Company or any of its Subsidiaries would prohibit the Company from effecting such payment, payment may be effected (to the extent permitted under such agreement or indenture) through a promissory note
having such commercially reasonable terms and interest rate as may be determined by the Company in its reasonable discretion; and provided further that
in any event such note shall become due at such time as the prohibitions described above shall lapse.

	(g)
	Notwithstanding
Section 8(f), the Company's Call Right (or right of the Company to purchase any portion of the Plan Shares or Rollover Shares hereunder) shall terminate on the
occurrence of an Initial Public Offering (as defined in the Shareholders' Agreement) unless a Purchase Notice has been delivered to Participant prior to such date in accordance with
Section 8(f); provided that the Company's Call Right for Plan Shares and Rollover Shares shall survive until the second anniversary of the
consummation of the Initial Public Offering if the Participant was terminated for Cause by the Company or if the Participant terminated his employment without Good Reason.

	(h)
	If
the Participant elects to exercise his or her Put Right under this Section 8, the Participant shall deliver written notice (a "Sale
Notice") to the Company to such effect within 90 days after the occurrence of the applicable event of termination. For purposes of this Section 8, the
"date of sale" shall mean the fifth business day following the receipt of a Sale Notice from the Participant. The proceeds from the sale of any Plan
Shares or Rollover Shares to the Company by the Participant (or his or her Permitted Transferee) pursuant to this Section 8 shall be applied first to the amount of any interest and principal
outstanding under any Loans owed by such Participant and secured by such Plan Shares or Rollover Shares, as the case may be, in accordance with the terms of such Loans. Any excess proceeds remaining
after repayment of all such interest and principal shall be paid to such Participant (or his or her Permitted Transferee) in cash or by certified check;  provided that if the terms of any agreement to
which the Company is a party, or any of the indentures governing any debt securities issued by the
Company or any of its Subsidiaries would prohibit the Company from effecting such payment, payment may be effected (to the extent permitted under such agreement or indenture) through a promissory note
having such commercially reasonable terms and interest rate as may be determined by the Company in its reasonable discretion; and provided further that
in any event such note shall become due at such time as the prohibitions described above shall lapse. 

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	(i)
	Notwithstanding
Section 8(h), a Participant's Put Right and the obligation of the Company to purchase any portion of the Plan Shares or the Rollover Shares hereunder shall
terminate on the occurrence of an Initial Public Offering (as defined in the Shareholders' Agreement) unless a Sale Notice has been delivered to the Company prior to such date in accordance with
Section 8(h); provided
that if the Participant's termination was due to death, disability or Qualified Retirement, the Participant's Put Right shall survive to the extent the applicable Shares and Rollover Shares remain
subject to transfer restrictions under the Shareholders' Agreement. 

        Section 9.
Loan Maturity Prior to Termination of Employment.

	(a)
	In
the event that an outstanding Loan becomes due prior to the termination of the applicable Participant's employment and prior to such time as the Shares and Rollover Shares are
publicly traded, the Participant shall have the right to cause the Company to purchase that portion of such Participant's Plan Shares or Rollover Shares, as the case may be, necessary to repay the
principal amount of the Loan and any interest thereon at a per share price equal to such Plan Shares' or Rollover Shares', as the case may be, Fair Market Value on the date of purchase by the Company.

	(b)
	If
a Participant elects to exercise his or her rights under this Section 9, the Participant shall deliver a Purchase Notice to the Company to such effect prior to the third
business day before the maturity date of the applicable Loan. The purchase price for such Plan Shares shall be applied and paid in the manner set forth in Section 8(f). 

        Section 10.
Shareholders' Agreement; Additional Restrictions. (a) A Participant shall, as a condition precedent to the
purchase of Shares under a Purchase Agreement, execute an instrument agreeing to be bound by the terms of the Shareholders' Agreement or, at the election of the Company, shall execute a counterpart of
the Shareholders' Agreement. In any event, any Shares shall be subject to the provisions in the Shareholders' Agreement regarding restrictions on transfer. 

	(b)
	The
Participant shall, as a condition to the purchase of Shares under a Purchase Agreement, agree that if such Participant at any time owns Shares that are not Plan Shares, and
intends to sell or otherwise dispose of such non-Plan Shares for value, such Participant must at the same time sell a sufficient number of Plan Shares such that the proportion of his or
her total Share holdings represented by Plan Shares immediately prior to such sale or disposition is preserved. To the extent a Participant intends to sell or otherwise dispose of, for value, Shares
purchased with cash or cash equivalents under a Purchase Agreement, the Participant must at the same time sell a proportionate number of Shares purchased with Loans under a Purchase Agreement. 

        Section 11.  Amendment and Termination.

	(a)
	Amendments
to and Termination of the Plan. Unless the Plan shall theretofore have been terminated as hereinafter provided, the Plan shall terminate on October 11, 2010. Subject
to any contractual restrictions affecting the Company, the Board may amend, alter, suspend, discontinue, or terminate the Plan or any portion thereof at any time;  provided that any such amendment,
alteration, suspension, discontinuance or termination that would adversely affect the rights of any Participant
under any Purchase Agreement shall not to that extent be effective without the consent of the affected Participant; provided further that no such
amendment, alteration, suspension, discontinuation or termination shall be made without stockholder approval if such approval is necessary to comply with any tax or regulatory requirement for which or
with which the Board deems it necessary or desirable to qualify or comply. 

7

 

	(b)
	Amendments
to Purchase Agreements. Subject to the terms of the applicable Purchase Agreement, the Committee may waive any conditions or rights under, amend any terms of, or alter,
suspend, discontinue, cancel or terminate, any Purchase Agreement, prospectively or retroactively; provided that any such waiver, amendment, alteration,
suspension, discontinuance, cancellation or termination that would adversely affect the rights of any Participant under any Purchase Agreement shall not to that extent be effective without the consent
of the affected Participant. 

        Section 12.
General Provisions.

	(a)
	No
Rights to Participation. No Employee, Participant or other Person shall have any claim to be granted the opportunity to purchase any Shares under a Purchase Agreement, and there is
no obligation for uniformity of treatment of Employees, Participants or their Permitted Transferees. The terms and conditions of Purchase Agreements need not be the same with respect to each
recipient.

	(b)
	Share
Certificates. Certificates issued in respect of Plan Shares shall, unless the Committee otherwise determines, be registered in the name of the Participant or his or her
Permitted Transferees and, so long as a Participant continues to be governed by the provisions of any Loan, shall be deposited by such Participant or Permitted Transferee, together with a stock power
endorsed in blank, with the Company. When the Participant ceases to be bound by the provisions of the Shareholders' Agreement and any Loan, the Company shall deliver such certificates to the
Participant upon request. Such stock certificate shall carry such appropriate legends, and such written instructions shall be given to the Company's transfer agent, as may be deemed necessary or
advisable by counsel to the Company in order to comply with the requirements of (i) the Securities Act, any state securities laws or any other applicable laws, (ii) the Shareholders'
Agreement and (iii) any Loan. Subject to the provisions of the Shareholders' Agreement, all certificates for Plan Shares or other securities of the Company or any Affiliate delivered under the
Plan pursuant to any Purchase Agreement shall be subject to such stop transfer orders and other restrictions as the Committee may deem advisable under the Plan, the applicable Purchase Agreement or
the rules, regulations and other requirements of the SEC or any stock exchange upon which Shares or other securities are then listed and any applicable laws or rules or regulations.

	(c)
	Execution
of Purchase Agreement; Disposition of Shares. No Shares shall be issued hereunder unless and until a Purchase Agreement shall be executed by the Company and the Participant.

	(d)
	No
Limit on Compensation Arrangements. Nothing contained in the Plan shall prevent the Company or any Subsidiary or Affiliate thereof from adopting or continuing in effect
compensation arrangements, which may, but need not, provide for the grant of options, restricted stock, Shares and other types of awards (subject to stockholder approval if such approval is required),
and such arrangements may be either generally applicable or applicable only in specific cases.

	(e)
	No
Rights to Employment. Nothing in this Plan or in any Purchase Agreement shall confer on any individual any right to continue in the employment of the Company or any Subsidiary or
Affiliate thereof or interfere in any way with the right of the Company or any Subsidiary or Affiliate thereof to terminate his or her employment at any time.

	(f)
	Governing
Law. The validity, construction, and effect of the Plan and any rules and regulations relating to the Plan and any Purchase Agreement shall be determined in accordance with
the laws of the State of Delaware, without application of the conflict of laws principles thereof. 

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	(g)
	Severability.
If any provision of the Plan or any Purchase Agreement is or becomes or is deemed to be invalid, illegal, or unenforceable in any jurisdiction or as to any Person or
Purchase Agreement, or would disqualify the Plan or any Purchase Agreement under any law deemed applicable by the Committee, such provision shall be construed or deemed amended to conform to the
applicable laws, or if it cannot be construed or deemed amended without, in the determination of the Committee, materially altering the intent of the Plan or the Purchase Agreement, such provision
shall be stricken as to such jurisdiction, Person or Purchase Agreement and the remainder of the Plan and any such Purchase Agreement shall remain in full force and effect.

	(h)
	Other
Laws. The Committee may refuse to issue or transfer any Shares or other consideration under a Purchase Agreement if, acting in its sole discretion, it determines that the
issuance or transfer of such Shares or such other consideration might violate any applicable law or regulation or entitle the Company to recover the same under Section 16(b) of the Exchange
Act, and any payment tendered to the Company by a Participant in connection therewith shall be promptly refunded to the relevant Participant. Without limiting the generality of the foregoing, no
Purchase Agreement shall be construed as an offer to sell securities of the Company, and no such offer shall be outstanding, unless and until the Committee in its sole discretion has determined that
any such offer, if made, would be in compliance with all applicable requirements of the U.S. Federal securities laws and any other laws to which such offer, if made, would be subject.

	(i)
	No
Trust or Fund Created. Neither the Plan nor any Purchase Agreement shall create or be construed to create a trust or separate fund of any kind or a fiduciary relationship between
the Company or any Affiliate and a Participant or any other Person. To the extent that any Person acquires
a right to receive payments from the Company or any Affiliate pursuant to a Purchase Agreement, such right shall be no greater than the right of any unsecured general creditor of the Company or any
Affiliate.

	(j)
	No
Fractional Shares. No fractional Shares shall be issued or delivered pursuant to the Plan or any Purchase Agreement, and the Committee shall determine whether cash or other
securities or other property shall be paid or transferred in lieu of any fractional Shares or whether such fractional Shares or any rights thereto shall be canceled, terminated, or otherwise
eliminated. 

        Section 13.
Effective Date. The Plan shall be effective as of October 11, 2000. 

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Exhibit A
  Summary of Plan Shares    
  

	 
	 	Rollover $

Amt.
	 	Loan $ Amt.
	 	Total $ Amt.
	 	Shares

	Bob Krakoff	 	$	4,200,000	 	$	4,200,000	 	$	8,400,000	 	840,000
	James Alic	 	$	1,300,000	 	$	1,300,000	 	$	2,600,000	 	260,000

10

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ADVANSTAR HOLDINGS CORP. Direct Investment Program

Exhibit A Summary of Plan Shares<Page>

                                                                   EXHIBIT 10.61

                           PURCHASE AND SALE AGREEMENT

                                 BY AND BETWEEN

                       SPAULDING AND SLYE HAYDEN WOODS LLC
                      A DELAWARE LIMITED LIABILITY COMPANY

                                    AS SELLER

                                       AND

                          CUBIST PHARMACEUTICALS, INC.
                             A DELAWARE CORPORATION

                                  AS PURCHASER

                               DATE: JULY 28, 2000

                                65 HAYDEN AVENUE,
                            LEXINGTON, MASSACHUSETTS

<Page>

                                TABLE OF CONTENTS
@@

<Table>
<S>                                                                             <C>
1.   PURCHASE AND SALE OF PROPERTY...............................................6
         1.1.   PURCHASE AND SALE................................................6
         1.2.   PROPERTY TRANSFERRED.............................................6

2.   PURCHASE PRICE, DEPOSIT AND MANNER OF PAYMENT...............................7
         2.1.   PURCHASE PRICE...................................................7
         2.2.   UNPAID TAXES AND CHARGES.........................................8
         2.3.   SATISFACTION OF LIENS AND ENCUMBRANCES...........................8
         2.4.   INTEREST ON DEPOSIT..............................................9

3.   COSTS AND ADJUSTMENTS AT CLOSING............................................9
         3.1.   ADJUSTMENTS......................................................9
         3.2.   SELLER'S COSTS...................................................9
         3.3.   ADJUSTMENTS.....................................................10
         3.4.   IN GENERAL; PRORATION STATEMENT.................................11
         3.5.   PURPOSE AND INTENT..............................................11
         3.6.   TAX REFUNDS.....................................................11
         3.7.   APPORTIONMENT OF TAXES..........................................12
         3.8.   UTILITY READINGS................................................12
         3.9.   SURVIVAL........................................................12

4.   PURCHASER'S DUE DILIGENCE/CONDITION OF THE
PROPERTY........................................................................12
         4.1.   DUE DILIGENCE EXAMINATIONS......................................12
         4.2.   EXTENSION.......................................................13
         4.3.   RESTORATION.....................................................13
         4.4.   DISCLOSURES.....................................................13
         4.5.   RETURN OF DUE DILIGENCE MATERIALS...............................14
         4.6.   PURCHASER'S TERMINATION RIGHT...................................14
         4.7.   AS IS SALE......................................................15
         4.8.   RELEASE.........................................................15
         4.9.   SCHEDULES AND EXHIBITS..........................................16

5.   TITLE MATTERS..............................................................16
         5.1.   PERMITTED EXCEPTIONS............................................16
         5.2.   PRELIMINARY TITLE REPORT........................................17
         5.3.   TITLE OBJECTIONS; TITLE DEFECT NOTICE...........................17
         5.4.   REMOVAL OF TITLE OBJECTIONS.....................................18

6.   CLOSING AND CLOSING CONDITIONS.............................................19
         6.1.   CLOSING.........................................................19
</Table>

<Page>

<Table>
<S>                                                                             <C>
         6.2.   PURCHASER'S CLOSING CONDITIONS..................................19
         6.3.   SELLER'S CONDITIONS PRECEDENT...................................21
         6.4.   ADDITIONAL PURCHASER CONDITIONS PRECEDENT.......................22
         6.5.   ADDITIONAL SELLER CONDITIONS PRECEDENT..........................24
         6.6.   GRACE AND CURE PERIODS..........................................25

7.   REPRESENTATIONS AND WARRANTIES.............................................25
         7.1.   PURCHASER'S REPRESENTATIONS AND WARRANTIES......................25
         7.2.   SELLER'S REPRESENTATIONS AND WARRANTIES.........................27
         7.3.   SELLER'S KNOWLEDGE..............................................29
         7.4.   SURVIVAL........................................................30
         7.5.   UNTRUE REPRESENTATION OR WARRANTY...............................30
         7.6.   SURVIVAL PERIOD.................................................31
         7.7.   MATERIAL MISREPRESENTATIONS.....................................31

8.   PURCHASER'S COVENANTS......................................................31
         8.1.   CONFIDENTIALITY.................................................31
         8.2.   NON-RELIANCE ON REPRESENTATIONS AND WARRANTIES..................33
         8.3.   PURCHASER INDEMNITY.............................................33
         8.4.   SURVIVAL........................................................34

9.   SELLER'S COVENANTS.........................................................34
         9.1.   SELLER'S OPERATION OF PROPERTY..................................34
         9.2.   ACCESS..........................................................34
         9.3.   NO MARKETING....................................................34

10.  COVENANTS OF SELLER AND PURCHASER..........................................34
         10.1.   PRESS RELEASES.................................................34
         10.2.   BROKERS........................................................35
         10.3.   ACCESS TO RECORDS..............................................35
         10.4.   NON-COMPLIANCE.................................................36
         10.5.   SURVIVAL.......................................................36

11.  FAILURE OF PERFORMANCE.....................................................36
         11.1.   PURCHASER DEFAULT..............................................36
         11.2.   SELLER DEFAULT.................................................37

12.  CONDEMNATION/CASUALTY......................................................37
         12.1.   CONDEMNATION...................................................37
         12.2.   CONDEMNATION AWARD.............................................38
         12.3.   CASUALTY.......................................................38
         12.4.   UNINSURED CASUALTY.............................................39
         12.5.   SELLER INSURANCE...............................................39
         12.6.   RETURN OF DEPOSIT..............................................39
         12.7.   PRIMACY OF AGREEMENT...........................................40
</Table>

                                       ii
<Page>

<Table>
<S>                                                                             <C>
13.  SELLER'S AND PURCHASER'S ACTIONS PRIOR TO THE CLOSING .....................40
         13.1.   NEW AGREEMENTS.................................................40

14.   NEW LEASES................................................................40
         14.1.   EXECUTION OF NEW LEASES........................................40
         14.2.   AMENDMENT......................................................40

15.  NOTICES....................................................................40

16.  TIME OF THE ESSENCE........................................................42

17.  SUCCESSORS AND ASSIGNS.....................................................42

18.   MISCELLANEOUS PROVISIONS..................................................42
         18.1.   MERGER.........................................................42
         18.2.   ENTIRE AGREEMENT; WAIVER.......................................42
         18.3.   GOVERNING LAW..................................................43
         18.4.   CAPTIONS.......................................................43
         18.5.   SUCCESSORS AND ASSIGNS.........................................43
         18.6.   SEVERANCE......................................................43
         18.7.   COUNTERPARTS...................................................43
         18.8.   NO RECORDING...................................................43
         18.9.   ADDITIONAL DOCUMENTS...........................................43
         18.10.  INTERPRETATION.................................................43
         18.11.  WAIVER OF JURY TRIAL...........................................44
</Table>

                                      iii
<Page>

@@
  EXHIBITS

<Table>
<S>              <C>
Exhibit A        Legal Description of the Land
Exhibit B        Schedule of Leases, Subleases, Licenses and Occupancy Agreements Relating to the Real Property
Exhibit C        Permit Rights Respecting the Real Property
Exhibit D        Owned Equipment, Equipment Leases and Laboratory Fixtures and Equipment Included in Sale
Exhibit E        Service Contracts for the Real Property
Exhibit F        Form of Escrow Agreement
Exhibit G        Form of Deed
Exhibit H        Form of Bill of Sale
Exhibit I        Form of Assignment and Assumption Agreement
Exhibit J        Certificate of Non-Foreign Status
Exhibit K        Form of Seller's Closing Certificate
Exhibit L        Form of Purchaser's Closing Certificate
Exhibit M        Initial Space Lease Termination Area
Exhibit N        Violations of Laws
Exhibit O        Environmental Reports
Exhibit P        Termination Agreement
Exhibit Q        Existing Insurance
</Table>

<Page>

                           PURCHASE AND SALE AGREEMENT

     THIS PURCHASE AND SALE AGREEMENT (this "AGREEMENT"), made as of the 28th
day of July, 2000, by and between SPAULDING AND SLYE HAYDEN WOODS LLC, a
Delaware limited liability company, having an office at c/o Spaulding and Slye
Company, 255 State Street, Boston, Massachusetts 02109 ("SELLER"), and CUBIST
PHARMACEUTICALS, INC., a Delaware corporation, having an office at 24 Emily
Street, Cambridge, Massachusetts 02139 ("PURCHASER").

                                    RECITALS

     Seller owns the land, and the buildings, structures and other improvements
situated thereon (collectively, the "IMPROVEMENTS"), more particularly described
on EXHIBIT A attached hereto and made a part hereof, known as and by the street
number 65 Hayden Avenue, Lexington, Middlesex County, Massachusetts (the "REAL
PROPERTY") comprising approximately 11.564 acres of land together with
appurtenant rights and easements. Seller desires to sell, transfer and convey
the Real Property, and Purchaser desires to purchase and acquire the Real
Property, upon and subject to the terms, covenants and conditions of this
Agreement.

                                   WITNESSETH:

     In consideration of the mutual covenants and agreements herein contained
and other good and valuable consideration, the receipt and sufficiency of which
are hereby separately acknowledged, and in reliance on all of the
representations, warranties and covenants made by each of the parties hereto,
Seller and Purchaser do hereby agree as follows:

                                   DEFINITIONS

     The following terms as used in this Agreement will have the meanings
attributed to such terms as set forth below unless the context clearly requires
another meaning. The terms set forth below do not necessarily constitute all
defined terms set forth in this Agreement; such other defined terms shall have
the meanings ascribed to such terms elsewhere in this Agreement.

     "ADDITIONAL DEPOSIT" shall have the meaning specified in SECTION 2.1.2 of
this Agreement.

     "ADJUSTMENT DATE" shall have the meaning specified in SECTION 3.3 of this
Agreement.

     "AFFILIATE" means, with respect to any Person, (i) any Person directly or
indirectly controlling, controlled by, or under control with, such Person; (ii)
any Person owning or controlling ten percent (10%) or more of the outstanding
voting

<Page>

interest of such Person; (iii) any Person of which such Person owns or controls
ten percent (10%) or more of the voting interests; or (iv) any officer,
director, general partner, member or trustee of such Person or of any such
Person referred to in (i), (ii) and (iii) above.

     "AGREEMENT" means this Purchase and Sale Agreement, as the same may be
amended, restated, supplemented or otherwise modified from time to time in
accordance with terms hereof.

     "BILL OF SALE" shall have the meaning specified in SECTION 6.2.2 of this
Agreement.

     "BROKER" shall have the meaning specified in SECTION 10.2 of this
Agreement.

     "BUSINESS DAY" means any day except Saturday, Sunday and any day that shall
be a legal holiday or a day on which banking institutions in the Commonwealth of
Massachusetts generally are authorized or required by Law or other government
actions to close.

     "CLOSING" shall have the meaning specified in SECTION 6.1 of this
Agreement.

     "CLOSING DATE" shall have the meaning specified in SECTION 6.1 of this
Agreement.

     "CLOSING TITLE DEFECT NOTICE" shall have the meaning specified in
SECTION 5.3.

     "DEED" shall have the meaning specified in SECTION 6.2.1 of this Agreement.

     "DEPOSIT" shall have the meaning specified in SECTION 2.1.3 of this
Agreement.

     "DUE DILIGENCE" shall have the meaning specified in SECTION 4.1 of this
Agreement.

     "DUE DILIGENCE EXPIRATION DATE" shall have the meaning specified in SECTION
4.6 of this Agreement.

     "ELECTION NOTICE" shall have the meaning specified in SECTION 12.3 of this
Agreement.

     "EQUIPMENT" shall have the meaning specified in SECTION 1.2.5 of this
Agreement.

     "EQUIPMENT LEASES" shall have the meaning specified in SECTION 1.2.6 of
this Agreement.

     "ESCROW AGENT" shall mean First American Title Insurance Company.

                                        2
<Page>

     "ESCROW AGREEMENT" shall have the meaning specified in SECTION 2.1.3 of
this Agreement.

     "EXTENSION NOTICE" shall have the meaning specified in SECTION 4.2 of this
Agreement.

     "GOVERNMENTAL ENTITY" means any agency, bureau, commission, court,
department, official, political subdivision, tribunal or other instrumentality
of any government, whether federal, state or local, domestic or foreign.

     "HAZARDOUS MATERIALS" means any substance, chemical, waste or material that
is or becomes regulated by any federal, state or local Governmental Entity
because of its toxicity, infectiousness, radioactivity, explosiveness,
ignitability, corrosiveness or reactivity, including, without limitation,
asbestos or any substance containing more than 0.1 percent asbestos, the group
of compounds known as polychlorinated biphenyls, flammable explosives, petroleum
or any refined petroleum product.

     "IMPROVEMENTS" shall have the meaning specified in the Recitals of this
Agreement.

     "INITIAL DEPOSIT" shall have the meaning specified in SECTION 2.1.1 of this
Agreement.

     "INITIAL SPACE LEASE TERMINATION AREA" shall have the meaning set forth in
SECTION 6.4.5.

     "LAW" means any present or future constitutional provision, federal, state
or local law, statute, ordinance, law, rule, regulation and any Order of any
Governmental Entity.

     "MATERIAL MISREPRESENTATIONS" shall have the meaning specified in SECTION
7.7 of this Agreement.

     "MONETARY ENCUMBRANCE" shall have the meaning specified in SECTION 5.2 of
this Agreement.

     "NEW LEASE" shall have the meaning specified in SECTION 14.1 of this
Agreement.

     "ORDER" means any decree, injunction, judgment, order, ruling, assessment
or writ, including, without limitation, any executive mandate of any
Governmental Entity.

     "PERMIT RIGHTS" shall have the meaning specified in SECTION 1.2.3 of this
Agreement.

                                        3
<Page>

     "PERMITTED EXCEPTIONS" shall have the meaning specified in SECTION 5.1 of
this Agreement.

     "PERSON" means an individual, partnership, corporation, limited liability
company, trust or unincorporated organization, or a government or agency or
political subdivision thereof.

     "PERSONAL PROPERTY" has the meaning specified in SECTION 1.2 of this
Agreement.

     "PRELIMINARY TITLE DEFECT NOTICE" shall have the meaning specified in
SECTION 5.3.

     "PRELIMINARY TITLE REPORT" shall have the meaning specified in SECTION 5.2
of this Agreement.

     "PRESS RELEASE" shall have the meaning specified in SECTION 10.1 of this
Agreement.

     "PROPERTY" shall have the meaning specified in SECTION 1.2 of this
Agreement.

     "PURCHASE PRICE" shall have the meaning specified in SECTION 2.1 of this
Agreement.

     "PURCHASER" shall have the meaning specified in the introduction of this
Agreement.

     "PURCHASER PARTIES" shall have the meaning specified in SECTION 8.1.1 of
this Agreement.

     "PURCHASER'S DOCUMENTS" shall mean this Agreement together with the
assumptions and other documents contemplated by this Agreement to be executed
and performed by Purchaser at or prior to the Closing.

     "PURCHASER'S REPRESENTATIVES" shall have the meaning specified in SECTION
4.1 of this Agreement.

     "PURCHASER'S TERMINATION NOTICE" shall have the meaning specified in
SECTION 4.6 of this Agreement.

     "REAL PROPERTY" shall have the meaning specified in the Recitals of this
Agreement.

     "REAL PROPERTY AGREEMENTS" shall have the meaning specified in SECTION
1.2.1 of this Agreement.

     "RECORDS" shall have the meaning specified in SECTION 1.2.4 of this
Agreement.

                                        4
<Page>

     "REMOVE", "REMOVED," OR "REMOVING" shall have the meaning specified in
SECTION 5.4 of this Agreement.

     "REPRESENTATION EXPIRATION DATE" shall have the meaning specified in
SECTION 7.6 of this Agreement.

     "SELLER" shall have the meaning specified in the introduction of this
Agreement.

     "SELLER'S ACTUAL KNOWLEDGE" shall have the meaning specified in SECTION 7.3
of this Agreement.

     "SELLER'S DOCUMENTS" shall mean this Agreement and the assignments and
other documents contemplated by this Agreement to be executed and performed by
Seller at the Closing.

     "SELLER PARTIES" shall have the meaning specified in SECTION 8.3 of this
Agreement.

     "SELLER'S REPRESENTATIVE" shall mean Peter A. Bailey.

     "SERVICE CONTRACTS" shall have the meaning specified in SECTION 1.2.6 of
this Agreement.

     "SIGNIFICANT PORTION" shall have the meaning specified in SECTION 12.1 of
this Agreement.

     "SPACE LEASE" shall mean that certain lease for the majority of the space
in the main office building at the Real Property, which lease is described on
EXHIBIT B attached hereto.

     "SURVEY" shall have the meaning specified in SECTION 5.1(b) of this
Agreement.

     "TERMINATION AGREEMENT" shall have the meaning specified in SECTION 6.4.5.

     "TITLE COMPANY" shall mean First American Title Insurance Company.

     "TITLE DEFECT NOTICE" shall have the meaning specified in SECTION 5.3 of
this Agreement.

     "TITLE OBJECTION" shall have the meaning specified in SECTION 5.3 of this
Agreement.

     "TITLE STANDARDS" shall have the meaning specified in SECTION 5.3.

     "TRANSACTION DOCUMENTS" shall mean this Agreement, the Purchaser's
Documents and the Seller's Documents.

                                        5
<Page>

1. PURCHASE AND SALE OF PROPERTY

     1.1. PURCHASE AND SALE.

     Seller agrees to sell, transfer and convey to Purchaser, and Purchaser
agrees to purchase and acquire from Seller, upon and subject to all of the
terms and conditions of this Agreement, the Real Property, including all
and any right, title and interest, if any, of Seller in and to any land
lying in the bed of any street, road or avenue opened or proposed, in front
of or adjoining the Real Property, to the center line thereof, and all
strips and gores adjoining the Real Property or any part thereof.

     1.2. PROPERTY TRANSFERRED.

     There shall be included in the sale of the Real Property:

          1.2.1. All of Seller's right, title and interest, if any, in and
     to any easements, declarations or other title agreements or
     instruments affecting or in any way connected to, restricting or
     benefiting the Real Property (the "REAL PROPERTY AGREEMENTS");

          1.2.2. All of Seller's right, title and interest, in and to (a)
     all leases, subleases, tenancies, subtenancies and occupancies for any
     part of the Real Property set forth on EXHIBIT B, as attached hereto
     and made a part hereof, and (b) unapplied security deposits, if any,
     and accrued and undistributed interest thereon and advance rents in
     respect of any period subsequent to the Closing Date paid by the
     tenant thereunder (the "SECURITY DEPOSITS");

          1.2.3. All of Seller's right, title and interest, if any, in and
     to all certificates of occupancy and transferable licenses and permits
     for the use, operation and ownership of the Real Property as currently
     operated, including, without limitation, those set forth on EXHIBIT C
     attached hereto and made a part hereof (the "PERMIT RIGHTS");

          1.2.4. All of Seller's right, title and interest, if any, and to
     the extent assignable, in (i) all drawings, plans and specifications
     in Seller's possession or control substantially relating to the Real
     Property or any part thereof, (ii) all third party studies and reports
     located at and covering the Real Property or any part thereof, (iii)
     all guaranties, warranties, indemnifications, undertakings and other
     assurances relating to the Real Property or any part thereof (but
     specifically excluding any such rights to the extent they relate to
     (1) any property other than the Property, or (2) any periods of time
     or portions thereof occurring prior to the Closing, which rights
     Seller shall retain), (iv) all operating and maintenance files, any
     management files and any other

                                        6
<Page>

     books, records and files (excluding appraisals, budgets, Seller's
     strategic plans for the Real Property, internal analyses, marketing
     information, submissions relating to Seller's obtaining entity
     authorization, attorney and accountant work product, or other
     information in the possession or control of Seller which Seller,
     acting reasonably, deems proprietary), which substantially relate to
     or are used in the ownership or operation of the Real Property and
     which are located at the situs of the Real Property or which are in
     the possession and control of Seller, subject, however, in all cases,
     to Seller's access rights as set forth in SECTION 10.3 below (all
     hereinafter collectively referred to as the "RECORDS").

          1.2.5. All of Seller's right, title and interest in and to the
     equipment and fixtures used exclusively in connection with the
     operation and maintenance of the Real Property, but excluding
     therefrom all of the personal property, equipment, computers,
     machinery and trade fixtures owned or leased (a) by the tenant under
     the Space Lease with the exception of all laboratory fixtures and
     equipment of said tenant contained in the largest building on the Real
     Property as of the date hereof and described on EXHIBIT D
     (collectively, the "LAB EQUIPMENT") , or (b) by any of the parties,
     other than Seller, to the Service Contracts (as defined in SECTION
     1.2.6), but which shall include, without limitation, the items listed
     on EXHIBIT D attached hereto or equivalent replacements thereof except
     to the extent that such items are depleted in the ordinary course of
     Seller's operation of the Real Property (the "EQUIPMENT") as well as
     all equipment leases relating to the Property listed on EXHIBIT D
     hereto (the "EQUIPMENT LEASES").

          1.2.6. All of Seller's right, title and interest in and to the
     contracts and agreements of which Seller is a party relating to the
     maintenance or operation of the Real Property, which are in effect on
     the Closing Date and which are listed on EXHIBIT E attached hereto, to
     the extent transferable by their terms (the "SERVICE CONTRACTS").

     The Permit Rights, Records and Equipment are hereinafter collectively
referred to as the "PERSONAL PROPERTY". The Real Property and the Personal
Property are hereinafter collectively referred to as the "PROPERTY".

2. PURCHASE PRICE, DEPOSIT AND MANNER OF PAYMENT

     2.1. PURCHASE PRICE.

     The purchase price for the Property is Thirty-Four Million Dollars
($34,000,000) (the "PURCHASE PRICE"), payable as follows:

                                        7
<Page>

          2.1.1. Within one (1) Business Day after the execution of this
     Agreement, Purchaser, by wire transfer in immediately available
     federal funds, shall deposit with the Escrow Agent, in an escrow
     account designated by the Escrow Agent, the sum of One Million Dollars
     ($1,000,000) (the "INITIAL DEPOSIT").

          2.1.2. Within one (1) Business Day after the date on which
     Purchaser delivers the Extension Notice to Seller, Purchaser, by wire
     transfer of immediately available federal funds, shall deposit with
     the Escrow Agent, in an escrow account designed by the Escrow Agent,
     the additional sum of Two Million Dollars ($2,000,000) (the
     "ADDITIONAL DEPOSIT").

          2.1.3. The Initial Deposit and the Additional Deposit shall be
     collectively referred to as the "DEPOSIT". The Deposit shall be held
     by the Escrow Agent in an interest bearing account in accordance with
     that certain Escrow Agreement of even date and execution herewith
     among Seller, Purchaser and the Escrow Agent (the "ESCROW AGREEMENT"),
     a copy of which is attached as EXHIBIT F to this Agreement. The
     Deposit shall be disbursed in accordance with the terms of this
     Agreement and the Escrow Agreement.

          2.1.4. At the Closing, the balance of the Purchase Price, plus or
     minus net adjustments and prorations provided for in ARTICLE 3 of this
     Agreement shall be payable by Purchaser by wire transfer (to an
     account designated in writing by Seller at or prior to the Closing) in
     immediately available federal funds.

     2.2. UNPAID TAXES AND CHARGES.

     The amount of any past due unpaid taxes, assessments, business
improvement district charges, public assembly charges, water charges and
sewer charges which Seller is obligated to pay and discharge, with the
interest and penalties thereon to the Closing Date shall be credited to
Purchaser out of the balance of the Purchase Price. The existence of any
such taxes shall not be deemed objections to title if Seller shall comply
with the foregoing requirements unless a taking for non-payment has been
made.

     2.3. SATISFACTION OF LIENS AND ENCUMBRANCES.

     If on the Closing Date there are any other liens or encumbrances on
the Property other than those to which Purchaser's title is to be subject
hereunder, Seller may use any portion of the balance of the Purchase Price
to satisfy the same, provided Seller shall simultaneously either (a)
deliver to Purchaser at the Closing instruments in recordable form and
sufficient to satisfy such liens and encumbrances of record, together with
the cost of

                                        8
<Page>

recording or filing said instruments, or (b) make arrangements with the
Title Company employed by Purchaser in advance of Closing, satisfactory to
the Title Company, to allow the issuance of title insurance to Purchaser
free of any such liens and encumbrances.

     2.4. INTEREST ON DEPOSIT.

     Whether or not the Closing shall occur hereunder, the party, whether
Seller or Purchaser, entitled to receive the Deposit deposited with the
Escrow Agent pursuant to SECTION 2.1. shall also be entitled to receive,
and Escrow Agent shall deliver to such Person, all interest earned on such
sums. The party receiving such sums and interest shall pay any income taxes
on such interest. Each party's taxpayer identification number is set forth
after the signature of such party at the end of this Agreement. Any such
interest shall not be deemed to be a credit to Purchaser against the
Purchase Price.

3. COSTS AND ADJUSTMENTS AT CLOSING

     3.1. ADJUSTMENTS. Purchaser will pay the following costs of closing
     this transaction:

          3.1.1. The fees and disbursements of its counsel, consultants,
     agents, contractors and advisors, if any;

          3.1.2. Recording fees to record and register the Deed and any
     other conveyance documents which are to be recorded to consummate the
     transaction set forth herein and the costs of municipal lien
     certificates and utility readings;

          3.1.3. One-half (1/2) of any escrow fees due to the Escrow Agent;

          3.1.4. The cost of preparing and issuing the Title Policy and any
     and all endorsements, issued in connection with this transaction,
     whether pursuant to the Preliminary Title Report or otherwise; and

          3.1.5. Any other expense(s) incurred by Purchaser or its
     consultants, agents, contractors and advisors in inspecting or
     evaluating the Property or closing this transaction or customarily
     paid by a purchaser of similar properties in the greater Boston area.

     3.2. SELLER'S COSTS.

     Seller will pay the following costs of closing this transaction:

                                        9
<Page>

          3.2.1. The fees and disbursements of Seller's counsel;

          3.2.2. Recording fees to record and register any instruments
     necessary to remove title exceptions which are not Permitted
     Exceptions and documentary stamps;

          3.2.3. One-half (1/2) of any escrow fees due to the Escrow Agent;

          3.2.4. The Broker's fee to the extent any such fee is payable
     pursuant to any separate agreements between Seller and the Broker; and

          3.2.5. Any other expense(s) incurred by Seller or its
     consultants, agents, contractors and advisors in inspecting or
     evaluating the Property or closing this transaction or customarily
     paid by a seller of similar properties in the greater Boston area.

     3.3. ADJUSTMENTS.

     The following adjustments are to be made at the Closing as of 11:59
P.M. of the day immediately preceding the Closing Date (the "ADJUSTMENT
DATE"):

          3.3.1. All current period's rents and other charges under the
     Space Lease and any New Leases.

          3.3.2. Prepaid and accrued items, such as fees for transferable
     licenses and permits, if any.

          3.3.3. Current charges and payments under the Service Contracts
     and Equipment Leases, if any.

          3.3.4. Water charges, sewer charges, gas, telephone, electricity
     and other utility services on the basis of the most recently issued
     bills therefor, in accordance with the provisions of SECTION 3.8,
     subject to adjustment after the Closing when the next bills are
     available, or if current meter readings are available, on the basis of
     such readings.

          3.3.5. Real estate taxes and assessments and excise taxes, for
     and on the basis of the fiscal year for which assessed, if assessed on
     or prior to the Closing Date subject, however, to the provisions of
     SECTION 3.6.

          3.3.6. Value of fuel, if any, stored on the Real Property, at
     Seller's cost, including any taxes, on the basis of a statement from
     Seller's supplier.

                                       10
<Page>

          3.3.7. Personal property taxes on the Personal Property, if any,
     on the basis of the fiscal year for which assessed.

          3.3.8. To the extent transferred to Purchaser, transferable
     deposits with any utility companies or other Persons who supply goods
     or services in connection with the operation of the Real Property
     which will remain on deposit after the Closing.

          3.3.9. If, on the Closing Date, the Real Property or any part
     thereof shall be or shall have been affected by an assessment or
     assessments which are or may become payable in annual installments, of
     which the first installment is then a charge or lien, or has been
     paid, then for the purposes of this Agreement all of the installments
     of any such assessments, including those which are to become due and
     payable after the Closing Date, shall be apportioned between the
     parties on the basis of amortizing the same on a straight-line basis
     over the term of such installments. This provision shall survive the
     Closing and delivery of the Deed to the Real Property.

     3.4. IN GENERAL; PRORATION STATEMENT.

     Any other costs or charges of closing this transaction not
specifically mentioned in this Agreement shall be paid and adjusted in
accordance with Boston, Massachusetts custom. Not later than five (5) days
prior to the Date of Closing Seller will give Purchaser a proposed
proration statement (the "PRORATION STATEMENT") (which shall contain per
diem amounts). Not later than two (2) days prior to the Date of Closing,
Purchaser may deliver to Seller a written statement of objections to such
Proration Statement with the reasons for such objections state in
reasonable detail. Purchaser and Seller shall then work together in good
faith to finalize the Proration Statement prior to Closing.

     3.5. PURPOSE AND INTENT.

     Except as expressly provided herein, the purpose and intent as to the
provisions of prorations and apportionments set forth in this Section 3 and
elsewhere in this Agreement is that Seller shall bear all expenses of
ownership and operation of the Property and shall receive all income
therefrom accruing through midnight at the end of the day preceding the
Closing and Purchaser shall bear all such expenses and receive all such
income accruing thereafter; PROVIDED, however, that if Seller does not
receive the Purchase Price in immediately-available funds by 2:00 p.m.
local Boston time on the Date of Closing, all adjustments and prorations
shall be made as of midnight on the day before the day on which Seller
receives the Purchase Price (provided that said receipt occurs on or before
2:00 p.m. on said day). Funds received after

                                       11
<Page>

2:00 p.m. on any day shall be deemed received before 2:00 p.m. on the following
Business Day.

     3.6. TAX REFUNDS.

     Purchaser hereby assigns to Seller all rights which it would otherwise
have, if any, for a tax saving or refund for all real estate and other
taxes due with respect to the Property for all tax years or portions
thereof prior to the Closing Date and hereby authorizes Seller to commence
or continue whatever actions or proceedings Seller may deem advisable in
order to effect any such saving or refund, in the name of Seller; PROVIDED,
HOWEVER, that all costs and expenses in respect to the prosecution of any
such claim, action or proceeding by Seller shall be borne entirely by
Seller; PROVIDED FURTHER, HOWEVER, that Seller shall not take any action in
connection with any such claim, action or proceeding which shall adversely
affect Purchaser's claim for a tax savings or refund for the portion of the
tax year subsequent to the Closing and for tax years subsequent to the tax
year in which the Closing shall occur. Seller and Purchaser shall not
withdraw, compromise or settle any such proceedings for the tax year in
which the Closing shall occur without the prior written consent of the
other, which consent Seller and Purchaser agree shall not be unreasonably
withheld or delayed. All tax savings which Purchaser may recover for the
tax year in which the Closing shall occur shall, after deducting all
reasonable costs and expenses in obtaining such savings (including, without
limitation, attorneys' fees), be apportioned between Seller and Purchaser,
and Purchaser shall promptly pay to Seller the Seller's allocable share of
the balance for the period prior to the Closing Date. Each of Seller and
Purchaser further agree to execute any and all further instruments and
documents which Purchaser or Seller, in its reasonable discretion, may deem
necessary in order to effect the provisions of this SECTION 3.6. The
provisions of this SECTION 3.6 shall survive the Closing and delivery of
the Deed to the Real Property.

     3.7. APPORTIONMENT OF TAXES.

     If the closing of the title shall occur before the tax rate is fixed,
the apportionment of taxes shall be upon the basis of the taxes actually
billed, but when the final tax rate is determined, there shall be a ratable
adjustment on a per diem basis between Seller and Purchaser if final taxes
vary from such billed taxes, with such adjustment to be completed within
ten (10) Business Days after either party has informed the other that
adjustment is necessary. The provisions of this SECTION 3.7 shall survive
the Closing and delivery of the Deed to the Real Property.

                                       12
<Page>

     3.8. UTILITY READINGS.

     As to charges for water, electricity, gas and other utilities for the
Property, Seller shall endeavor to furnish a current meter reading at the
Closing, which readings shall have been made not earlier than two (2)
Business Days prior to the time herein set for Closing, and Seller shall
pay the charges therefor to such date. In the event that such a meter
reading cannot be obtained, Seller shall furnish a reading to a date not
more than thirty (30) days prior to the time herein set for Closing, and
the unfixed meter charge based thereon for the intervening time shall be
apportioned on the basis of such last reading; in such event the parties
agree to notify the utility company to read the meters as soon as possible
after Closing and to render a final bill to Seller. The final bill shall be
apportioned as of the Closing Date. The provisions of this SECTION 3.8
shall survive the Closing and delivery of the Deed to the Real Property.

     3.9. SURVIVAL.

     The provisions of this Article 3 which require any act to be performed
after the Closing shall survive the Closing.

4. PURCHASER'S DUE DILIGENCE/CONDITION OF THE PROPERTY

     4.1. DUE DILIGENCE EXAMINATIONS.

     Subject to the provisions of this Agreement, Purchaser, its employees,
agents, contractors, consultants, attorneys and other authorized
representatives (collectively, "PURCHASER'S REPRESENTATIVES") shall have
the right to conduct or cause to be conducted, at Purchaser's sole cost and
expense, such examinations, inspections, testing, studies and/or
investigation (herein collectively called the "DUE DILIGENCE") of the
Property and information regarding the Property, as Purchaser deems
necessary or desirable. Purchaser and Purchaser's Representatives shall be
allowed access to the Real Property for the purpose of making all
inspections and tests it deems necessary in the conduct of its Due
Diligence, provided that Purchaser has given notice to Seller's
Representative of its intent to make such entry and, with respect to the
performance of any environmental tests or studies of the Real Property
involving sampling, testing or analyzing samples of air, water or soil:

          (a) Purchaser shall first notify Seller's Representative at least
one (1) Business Day in advance as to the (i) identity of the Persons who
shall perform such tests or studies, and (ii) the proposed scope of such
tests and studies; within one (1) Business Day of receipt of Purchaser's
notice Seller shall notify Purchaser of its approval or of any requested
changes to the scope of work; failure to give notice within such one (1)
Business Day period shall be deemed to constitute approval; and

                                       13
<Page>

          (b) Purchaser shall not perform any environmental tests or
studies of the Real Property which exceed the scope of the work as so
approved by Seller.

     4.2. EXTENSION.

     Notwithstanding any other provision set forth herein Purchaser shall
have the right, exercisable in its sole discretion at any time on or prior
to the Due Diligence Expiration Date by delivery of written notice to
Seller (the "EXTENSION NOTICE"), to extend the Closing Date until September
8, 2000, PROVIDED that the Extension Notice shall be deemed valid only if
Purchaser wires to Seller the Additional Deposit in accordance with SECTION
2.1.2 within one (1) Business Day of the date on which the Extension Notice
is delivered to Seller.

     4.3. RESTORATION.

     Purchaser shall, immediately after the conclusion of each portion of
Purchaser's testing, restore the Real Property at its sole cost to its
pre-existing condition, including replacing paving and landscaping. The
foregoing restoration obligation of Purchaser contained in this SECTION 4.3
shall survive any termination of this Agreement.

     4.4. DISCLOSURES.

     In the event the need arises to notify under applicable Law any
federal, state or local public agencies of any environmental conditions at
the Real Property, as a result of Purchaser's Due Diligence investigations,
Purchaser shall immediately notify Seller and agrees that Seller, and not
Purchaser or Purchaser's Representatives, shall make such disclosure as
Seller deems appropriate, unless such disclosure is required by Law to be
made by Purchaser or Purchaser's Representatives, in which instance
Purchaser or Purchaser's Representatives shall immediately notify Seller in
writing of their intention to make said disclosure and unless Seller
informs Purchaser or Purchaser's Representatives in writing within one (1)
Business Day of Seller's intention to make said disclosure Purchaser and
Purchaser's Representatives shall be free to make said disclosure. If
Seller gives such notice but fails within three (3) Business Days to
provide Purchaser with reasonable evidence that said disclosure has been
made Purchaser shall again be free to make said disclosure.

     4.5. RETURN OF DUE DILIGENCE MATERIALS.

     If for any reason the Closing does not occur, Purchaser shall (i)
return to Seller all materials and other information regarding the Property
that Seller has provided to Purchaser and all photocopies thereof, and (ii)
deliver

                                       14
<Page>

immediately to Seller copies of all written studies, analyses, reports and
assessments (both final and interim versions) relating to any of
Purchaser's Due Diligence investigations involving environmental testing,
soil testing or inspection of the Real Property, and copies of all surveys
and title reports or commitments (and copies of the underlying recorded
documents referenced therein). Notwithstanding such termination of this
Agreement, Purchaser shall maintain the confidentiality of all materials
and information described in clauses (i) and (ii) of the preceding
sentence, except as otherwise required by Law or by Order of any
Governmental Entity, in accordance with the provisions of SECTION 8.1.1.
The provisions of this SECTION 4.5 shall survive the termination of this
Agreement but shall not survive the Closing.

     4.6. PURCHASER'S TERMINATION RIGHT.

     Subject to the provisions of the last paragraph of this SECTION 4.6,
Purchaser shall have the right to elect to terminate this Agreement by
giving written notice (the "PURCHASER'S TERMINATION NOTICE") of such
election to the Seller at any time prior to 5:00 p.m. on August 12, 2000
(the "DUE DILIGENCE EXPIRATION DATE") if the Purchaser shall determine in
its sole and absolute discretion that it is not absolutely satisfied with
any aspect of the Property.

     If for any reason whatsoever the Seller shall not have received the
Purchaser's Termination Notice prior to the Due Diligence Expiration Date,
the Purchaser shall be deemed to have irrevocably waived the right of
termination granted under this SECTION 4.6, and such right of termination
shall be of no further force or effect.

     If this Agreement is terminated pursuant to this SECTION 4.6,
Purchaser shall comply with the requirements of SECTION 4.5 above, and
Purchaser shall be entitled to and shall receive the immediate return of
the Deposit, together with all interest accrued thereon. In such event,
except as expressly provided otherwise herein, this Agreement shall be of
no further force and effect and the parties hereto shall have no further
rights, obligations or liabilities hereunder.

     4.7. AS IS SALE.

     If, pursuant to the provisions of SECTION 4.6 hereof, this Agreement
is not terminated and remains in effect on the Due Diligence Expiration
Date, Purchaser shall be deemed to have acknowledged that it is satisfied
with the results of its Due Diligence, having relied upon its own Due
Diligence of the Property and not upon any information (including,
specifically, without limitation, any offering memorandum or other property
information packages or Due Diligence documents distributed with respect to
the Property) provided by or on behalf of Seller, Seller's Affiliates, or
their respective agents,

                                       15
<Page>

consultants, employees or other representatives with respect thereto, other
than such representations, warranties and covenants of Seller as are
expressly set forth in this Agreement, and Purchaser agrees that the
Property shall be sold, and that Purchaser shall accept possession of the
Property on the Closing Date, "AS IS, WHERE IS, WITH ALL FAULTS". Pursuant
to and subject to the conditions set forth in SECTION 4.1 hereof, Purchaser
shall continue to have access to the Property subsequent to the Due
Diligence Expiration Date for further review and inspection, but Purchaser
shall not be entitled to terminate this Agreement based on such inspection.

     4.8. RELEASE.

     Upon the Due Diligence Expiration Date, except as provided in Article
7 and 11 and otherwise expressly provided in this Agreement, Purchaser
shall assume the risk that adverse matters, including but not limited to,
construction defects and adverse physical and environmental conditions, may
not have been revealed by Purchaser's Due Diligence investigations, and
Purchaser shall, except as otherwise expressly provided in this Agreement,
be deemed to have waived, relinquished and released Seller, Seller's
Affiliates (and Seller's and Seller's Affiliates members, representatives,
officers, directors, and employees) from and against any and all claims,
demands, causes of action (including causes of action in tort), losses,
damages, liabilities, costs and expenses (including attorneys' fees and
court costs) of any and every kind or character, known or unknown, which
Purchaser might have asserted or alleged against Seller, Seller's
Affiliates (and Seller's and Seller's Affiliates members, representatives,
officers, directors, and employees) at any time by reason of or arising out
of any latent or patent construction defects or physical conditions,
violations of any applicable Law (including, without limitation, any
environmental Laws) and any and all other acts, omissions, events,
circumstances or matters regarding the Property, PROVIDED that nothing in
this SECTION 4.8 shall be deemed to prevent Purchaser and each of its
affiliates, successors, assigns, employees, agents, participants,
shareholders, or directors from naming Seller as a third party defendant in
a proceeding against Purchaser asserting claims relating to the generation,
storage or release of Hazardous Materials at the Property brought by
parties other than Purchaser, which relate to a period of time during which
Seller held fee simple title to the Property. Notwithstanding the foregoing
provisions, nothing set forth in this SECTION 4.8 shall be interpreted or
construed as limiting, restricting, extinguishing or otherwise affecting
Seller's representations and warranties made in this Agreement or the
survivability thereof for the time limitation herein provided.

                                       16
<Page>

     4.9. SCHEDULES AND EXHIBITS.

     Purchaser and Seller acknowledge that the Exhibits to this Agreement
are currently being prepared and will not be available at the time of
execution of this Agreement. Seller and Purchaser agree to complete all of
the Exhibits for attachment to this Agreement on or before seven (7) days
after the date hereof. In the event that such Exhibits are not completed by
such date, either Purchaser or Seller may elect to terminate this
Agreement, in which event the Deposit shall be returned to Purchaser, and
Seller and Purchaser shall have no further rights or obligations hereunder,
except with respect to those terms and provisions of this Agreement which
survive such a termination.

5. TITLE MATTERS

     5.1. PERMITTED EXCEPTIONS.

     Except as provided in SECTION 5.2, and unless this Agreement is
terminated by Purchaser pursuant to SECTION 4.6 or SECTION 5.3, Seller
shall cause the Real Property to be transferred and conveyed to Purchaser,
and Purchaser shall accept fee title to the Real Property at Closing,
subject to the following matters (collectively, the "PERMITTED
EXCEPTIONS"):

          (a) Any title matters;

          (b) Any state of facts which a current and accurate ALTA/ACSM
survey of the Real Property (a "SURVEY") obtained prior to the Closing
would disclose;

          (c) All Laws including, without limitation, all historical
preservation, environmental, building, subdivision and zoning restrictions,
codes, ordinances and regulations, affecting the Real Property or the
ownership, use or operation thereof adopted by the United States, the
Commonwealth of Massachusetts, the Town of Lexington, and any and every
other agency, department, instrumentality and/or political subdivision of
government of every kind whatsoever having jurisdiction thereof, and all
amendments or additions thereto now in effect or which may be in force and
effect on the Closing Date;

          (d) Unpaid personal property taxes owed by Seller for the
Property, unpaid real estate taxes, unpaid excise taxes, water and sewer
charges which are not yet due and payable but which may be a lien on all or
a portion of the Property, subject to adjustment as hereinabove provided in
ARTICLE 3;

          (e) The Space Lease, subject to the Termination Agreement
described below in SECTION 6.4.5;

                                       17
<Page>

          (f) The Equipment Leases, if there be any identified on EXHIBIT D
attached hereto if assumed by Purchaser at its election as hereinafter
provided; and

          (g) The Service Contracts listed in EXHIBIT E attached hereto
which Purchaser elects to assume as hereinafter provided.

     5.2. PRELIMINARY TITLE REPORT.

     On or before the date which is fifteen (15) days after the execution
hereof, Purchaser, at its sole expense, shall obtain a commitment for the
issuance of an Owner's Policy of Title Insurance (the "PRELIMINARY TITLE
REPORT") from the Title Company, together with copies of all documents
constituting exceptions to Seller's title as reflected in the Preliminary
Title Report, and shall obtain a Survey of the Real Property, and promptly
shall provide copies thereof (and any updates thereto) to Seller. Purchaser
may cause the Preliminary Title Report to be updated and may cause such
Survey to be updated, revised and/or re-certified at Purchaser's sole cost
and expense. All matters identified on the Preliminary Title Report and the
Survey shall be a Permitted Exception except for any matters which
Purchaser includes in its Title Objection Notice pursuant to SECTION 5.3
below.

     5.3. TITLE OBJECTIONS; TITLE DEFECT NOTICE.

     Purchaser shall have the right to object in writing (a "TITLE DEFECT
NOTICE") (i) to any title matters disclosed by the Preliminary Title Report
or the Survey by a Title Defect Notice delivered to Seller by Purchaser on
or before the Due Diligence Expiration Date (the "PRELIMINARY TITLE DEFECT
NOTICE"), and (ii) to any title matters that first arise after the later of
July 15, 2000 or the date of the Preliminary Title Report that materially
interfere with the use of the Property for laboratory and office use or
would cause title to be unmarketable (based on the most recent standards as
of the date hereof published in "The Massachusetts Conveyancers
Association's Handbook of Standards and Forms", sometimes referred to
herein as the "TITLE STANDARDS") by a Title Defect Notice delivered at or
before the Closing (a "CLOSING TITLE DEFECT NOTICE"). Any such title
matters to which Purchaser shall have timely objected in the Title Defect
Notice shall be collectively referred to herein as a "TITLE OBJECTION".
Within one (1) Business Day of Seller's receipt of a Closing Title Defect
Notice and within three (3) Business Days of Seller's receipt of a
Preliminary Title Defect Notice, Seller shall notify Purchaser in writing
of those matters in the Title Defect Notice which Seller is willing to
cure, PROVIDED THAT, (i) Seller shall be obligated to Remove any mortgage
or other lien against the Property securing a liquidated sum that is a
Title Objection which Seller shall have voluntarily placed or permitted to
be placed upon or against the Real Property (collectively, a "MONETARY

                                       18
<Page>

ENCUMBRANCE") and, (ii) Seller shall use reasonable efforts to Remove any
Title Objections which would render title to the Property unmarketable
(based on the Title Standards) provided that Seller shall not be required
to spend in the aggregate more than One Hundred Thousand Dollars ($100,000)
to Remove or cure the same, exclusive of any Monetary Encumbrances, which
Seller shall be obligated to Remove without regard to the amount thereof.
Unless Seller notifies Purchaser that it elects to cure the Title Objection
and thereafter timely cures the Title Objection in accordance with the
Title Standards, then if Purchaser is not satisfied, in its sole
discretion, with Seller's response to the Title Defect Notice, Purchaser
shall have the right to terminate this Agreement by delivering written
notice to Seller within three (3) Business Days of Purchaser's receipt of
said response notice from Seller. If Purchaser does not so terminate it
shall be deemed to have waived the Title Objection. Seller shall be
entitled at Seller's election by notice to Purchaser to extend the Closing
(not to exceed thirty (30) calendar days) in order to provide Seller
additional time in which to Remove any such Title Objection. If Seller is
unable to Remove any Title Objection prior to the Closing or any extended
Closing as provided herein, Purchaser may elect either to (a) terminate
this Agreement by notice to Seller and the Escrow Agent, in which event the
Deposit plus all interest accrued thereon shall be returned to Purchaser
and, thereafter, the parties shall have no further rights or obligations
hereunder, except as provided in any Section hereof that by its terms
expressly provides that it survives any termination of this Agreement, or
(b) waive such Title Objections, in which event such Title Objections shall
be deemed Permitted Exceptions and the Closing shall occur as herein
provided without any reduction of or credit against the Purchase Price. The
provisions of the preceding sentence shall not be construed or interpreted
so as to permit Seller to avoid Removing any Monetary Encumbrance which,
pursuant to the terms of this Agreement, are required to be Removed by
Seller prior to or concurrently with the Closing.

     5.4. REMOVAL OF TITLE OBJECTIONS.

     If on the Closing Date, as the same may be extended pursuant to SECTION
5.3, there are any Title Objections that Seller is required to Remove as
provided herein, Seller shall Remove the same at the Closing. The term "REMOVE,"
"REMOVED," or "REMOVING", as used in this Agreement, shall mean that Seller
shall remove or cause the Title Company to remove the same as an exception to
title in Purchaser's title policy or to insure against the same in a manner
reasonably acceptable to Purchaser, without any additional cost to Purchaser,
whether such insurance is made available in consideration of payment, bonding,
indemnity of Seller or otherwise. If the Closing occurs, Seller may use the
proceeds of the Purchase Price to Remove Title Objections.

                                       19
<Page>

6. CLOSING AND CLOSING CONDITIONS

     6.1. CLOSING.

     The closing ("CLOSING") of the transactions contemplated hereby shall occur
on August 22, 2000 as such date may be extended or accelerated upon the mutual
written agreement of Seller and Purchaser (the "CLOSING DATE"), provided, that
if the Extension Notice has been given in accordance with SECTION 4.2 the
Closing Date shall be extended to September 8, 2000 as such date may be further
extended or accelerated upon the mutual written agreement of Seller and
Purchaser. The Closing shall be conducted through the use of an escrow with the
Title Company, under which all conveyance, assignment and other documents, and
the balance of the cash Purchase Price shall be deposited in such escrow, in
accordance with reasonable and customary closing instructions jointly given by
Seller and Purchaser (which may require a "New York Style" or "Gap" closing);
provided that all documents and funds shall be delivered as of the Closing Date.
The Closing shall take place at 10:00 A.M., Eastern Time, at the offices of
Bingham Dana LLP, 150 Federal Street, Boston, Massachusetts 02110, or at such
other place and time of day as may be agreed upon in writing by Seller and
Purchaser. Seller and Purchaser shall conduct a "pre-closing" on the day
immediately prior to the Closing Date. Seller and Purchaser, separately or
collectively, as appropriate for each item, shall escrow with the Title Company
on the day immediately prior to the Closing Date the fully executed, notarized
and recordable Deed (as hereinafter defined) for the Real Property, Bill of Sale
for the Personal Property, and each of the additional items listed in this
ARTICLE 6 as documents to be respectively delivered by Seller and Purchaser,
such documents to be held by the Title Company pursuant to an escrow letter or
letters to be provided by Seller and Purchaser on or before the Closing Date. If
Seller and Purchaser execute separate escrow instructions, such separate escrow
instructions shall constitute separate agreements between the Title Company on
the one hand and Seller or Purchaser, as the case may be, on the other hand, and
shall not constitute agreements between Seller and Purchaser. Such separate
escrow instructions shall be enforceable only to the extent not inconsistent
with this Agreement. Title transfer and delivery of the Purchase Price is to be
completed on the Closing Date as set forth in this SECTION 6.1. Time is of the
essence with respect to the Closing Date.

     6.2. PURCHASER'S CLOSING CONDITIONS.

     At the Closing, and as a condition to Purchaser's obligation to purchase
the Property and pay the Purchase Price and deliver the Purchaser's Documents,
Seller will duly execute, acknowledge (where appropriate) and/or deliver to
Purchaser or the Title Company, as applicable, the following:

          6.2.1. A statutory quitclaim deed in the form of EXHIBIT G attached
     hereto duly executed and acknowledged by Seller, conveying to

                                       20
<Page>

     Purchaser fee simple title to the Real Property, subject to and in
     accordance with the provisions of this Agreement (the "DEED").

          6.2.2. A Bill of Sale, in the form of EXHIBIT H attached hereto,
     transferring all of Seller's right, title and interest in and to the
     Personal Property owned by Seller (the "BILL OF SALE").

          6.2.3. The landlord's executed counterparts (or, where originals are
     unavailable, copies thereof certified by Seller) of all Service Contracts
     and Equipment Leases assumed by Purchaser hereunder (which shall be made
     available to Purchaser at Seller's address first set forth above).

          6.2.4. An assignment from Seller, in the form of EXHIBIT I attached
     hereto, of (a) the Space Lease (subject to the Termination Agreement), (b)
     any Service Contracts and Equipment Leases assumed by Purchaser hereunder,
     (c) the Real Property Agreements, (d) transferable Permit Rights, (e)
     Equipment Leases, if any, (f) warranties and guaranties if any, respecting
     the Property (provided that said assignment shall explicitly exclude any
     warranty or guaranty rights relating to (1) any property other than the
     Property, and (2) any periods of time or portions thereof occurring prior
     to the Closing, which rights Seller shall retain), and (g) Records.

          6.2.5. Any Security Deposits and the accrued and undistributed
     interest on any such Security Deposits, less permitted administrative
     charges, if any, together with a schedule thereof. Such Security Deposits
     and interest shall be delivered by Seller by (i) wire transfer in
     immediately available federal funds to an account designated by Purchaser
     at least one (1) Business Day prior to the Closing, or if no such account
     is so designated by Purchaser, by a separate certified or official bank
     check payable to the order of Purchaser, or (ii) by a credit to Purchaser
     against the Purchase Price, provided that with respect to any Security
     Deposits which are other than cash, Seller's Nominee shall execute and
     deliver to Purchaser at the Closing any appropriate instruments of
     assignment or transfer.

          6.2.6. Notices addressed to the tenant under the Space Lease, executed
     by or on behalf of the landlord named in the Space Lease, dated the Closing
     Date, notifying the tenant of the transfer of the Property to Purchaser,
     and advising the tenant that Purchaser as landlord is responsible for and
     shall hold the Security Deposit (and interest thereon) provided for under
     said tenant's Space Lease in accordance with the terms of such Space Lease
     and with the provisions of Law, and directing that rents and other payments
     under such

                                       21
<Page>

     tenant's Space Lease thereafter be sent to Purchaser or as Purchaser may
     direct. Purchaser and Seller shall immediately after the Closing jointly
     cause such letters to be mailed by certified mail to said tenant at the
     address provided in the Space Lease for the delivery of notices or other
     communications to said tenant.

          6.2.7. All available keys to entrance doors to, and equipment and
     utility rooms located in, the Real Property.

          6.2.8. (a) Originals or copies of all Records which are being sold to
     Purchaser by Seller pursuant to SECTION 1.2.

          6.2.9. an original Termination Agreement executed and delivered by
     Seller and all tenants or occupants of the Property shown on EXHIBIT B in
     accordance with the provisions of SECTION 6.4.5.

          6.2.10. Documentation to establish to the reasonable satisfaction of
the Title Company the due authorization of Seller's consummation of the
transaction and delivery of the Seller's Documents to be delivered by it
pursuant to this Agreement, and a certificate of an authorized officer or
official, evidencing that the individual signing all Seller's Documents
hereunder on behalf of Seller is authorized to do so.

          6.2.11. A so-called FIRPTA affidavit duly executed by Seller stating
that Seller is not a "FOREIGN PERSON" within the meaning of Section 1445 or 7701
of the Code in the form of EXHIBIT J attached hereto.

          6.2.12. Affidavits and indemnifications executed by Seller regarding
mechanics' and materialmen's liens and parties in possession sufficient to
eliminate on Purchaser's title insurance policy exceptions for these matters,
other than those matters as to which Purchaser has agreed pursuant to this
Agreement to accept title to the Real Property subject thereto.

          6.2.13. Such other and further documents and instruments as may be
reasonably required by Seller or the Title Company to consummate the transaction
or as may otherwise be required by the terms of this Agreement.

     6.3. SELLER'S CONDITIONS PRECEDENT.

     At the Closing, and as a condition to Seller's obligation to sell the
Property and deliver the Deed and other Seller's Documents, Purchaser will duly
execute, acknowledge (where appropriate) and/or deliver to Seller or the Title
Company, as applicable, the following:

                                       22
<Page>

          6.3.1. The balance of the Purchase Price in accordance with SECTION
     2.1.4 hereof.

          6.3.2. An assumption from Purchaser, in the form of EXHIBIT I attached
     hereto, from and after the Closing Date, of the Space Lease (subject to the
     Termination Agreement), any Service Contracts and Equipment Leases assumed
     by Purchaser hereunder, Real Property Agreements, transferable Permit
     Rights, and, if applicable, Equipment Leases.

          6.3.3. The letters to tenants referred to in SECTION 6.2.6 signed by
     or on behalf of Purchaser.

          6.3.4. Documentation to establish to Seller's reasonable satisfaction
     the due authorization of Purchaser's acquisition of the Property and
     Purchaser's delivery of the Purchaser's Documents required to be delivered
     by Purchaser pursuant to this Agreement, including an incumbency
     certificate of an authorized officer or official with respect to the
     authority to act on behalf of Purchaser of the individual executing on
     behalf of Purchaser all closing documents contemplated by this Agreement.

          6.3.5. Such other and further documents and instruments as may be
     reasonably required by Seller or the Title Company or as may be agreed upon
     by Seller and Purchaser to consummate the transaction or as may otherwise
     be required by the terms of this Agreement.

     6.4. ADDITIONAL PURCHASER CONDITIONS PRECEDENT.

     Purchaser's obligation to close the transaction is conditioned further upon
the satisfaction of all of the following, any or all of which may be waived by
Purchaser by an express written waiver, at its sole option:

          6.4.1. All representations and warranties made by Seller in SECTION 7
     this Agreement shall be true and correct in all material respects on and as
     of the Closing Date, as if made on and as of such date except to the extent
     that they expressly relate to an earlier date and Seller shall have
     complied in all respects with all agreements required to be performed by it
     hereunder at or prior to the Closing Date.

          6.4.2. At the Closing Date, Purchaser shall have received a
     certificate, dated the Closing Date, signed by Seller to the effect set
     forth in SUBSECTION 6.4.1, certifying that Seller has received all
     necessary internal approvals and authorizations necessary in connection
     with its sale of the Property to Purchaser pursuant to the Agreement, and
     stating that the conditions specified in this SECTION 6.4 have been

                                       23
<Page>

     satisfied at the Closing Date, in substantially the form attached hereto as
     EXHIBIT K.

          6.4.3. Seller shall have delivered all the Seller's Documents and
     other items required pursuant to SECTION 6.2 and shall have performed all
     other covenants, undertakings and obligations in all respects, and complied
     with all conditions required by this Agreement, to be performed or complied
     with by Seller at or prior to the Closing.

          6.4.4. No Law or Order shall have been enacted, entered, issued,
     promulgated or enforced by any Governmental Entity between the Due
     Diligence Expiration Date and the Closing which prohibits or substantially
     restricts the use of the Property as laboratory and office facilities as
     contemplated by this Agreement.

          6.4.5. Seller shall have delivered to the Escrow Agent at or prior to
     the Closing an original Termination of Lease Agreement ("TERMINATION
     AGREEMENT") in recordable form executed and delivered by Seller and the
     tenants or occupants listed on EXHIBIT B providing for (i) the termination
     of all said tenancies or occupancies with respect to that certain portion
     of the premises commonly known as the "Chemical" outbuilding at the rear of
     the Real Property containing approximately Eleven Thousand (11,000) square
     feet and shown on EXHIBIT M attached hereto (the "INITIAL SPACE LEASE
     TERMINATION AREA") effective as of a date not later than September 1, 2000,
     and (ii) the termination of all said tenancies or occupancies in their
     entirety as of December 31, 2000. The form of the Termination Agreement is
     attached hereto as EXHIBIT P.

          6.4.6. Seller shall not have entered into any lease, sublease, license
     or occupancy agreement in any form with respect to the Property other than
     those listed on EXHIBIT B attached hereto.

          6.4.7. Seller shall have used reasonable efforts to obtain and deliver
     to Purchaser an estoppel certificate from the "Declarant" or its successor
     in interest under the Amended and Restated Declaration of Covenants and
     Easements dated as of November 8, 1999 as to the absence of amendments
     thereto or defaults thereunder. For purposes of the preceding sentence,
     "reasonable efforts" shall mean that Seller shall have forwarded said
     document to the Declarant and requested said Declarant to execute and
     deliver same and shall include a limited number of follow up telephone
     calls and a limited number of follow up letters requesting such execution
     and delivery, but shall not require Seller to expend monies.

                                       24
<Page>

          6.4.8. Seller shall have used reasonable efforts to obtain and deliver
     to Purchaser, subordination, non-disturbance and attornment agreements from
     all tenants or occupants of the Property as of the Closing. For purposes of
     the preceding sentence, "reasonable efforts" shall mean that Seller shall
     have forwarded said document(s) to said tenants and occupants and requested
     them to execute and deliver same and shall include a limited number of
     follow up telephone calls and a limited number of follow up letters
     requesting such execution and delivery, but shall not require Seller to
     expend monies.

          6.4.9. All of the Lab Equipment shall be on the Property as of the
     Closing, free of any claims of any current or former tenant or occupant of
     the Property and in substantially the same condition as it was in as of the
     of date hereof, reasonable wear and tear excepted.

     6.5. ADDITIONAL SELLER CONDITIONS PRECEDENT.

     Seller's obligation to close the transaction is conditioned further upon
the satisfaction of all of the following, any or all of which may be waived by
Seller by an express written waiver at its sole option:

          6.5.1. All representations and warranties made by Purchaser in this
     Agreement shall be true and correct in all respects on and as of the
     Closing Date, as if made on and as of such date except to the extent they
     expressly relate to an earlier date and Purchaser shall have complied in
     all respects with all agreements required to be performed by it hereunder
     at or prior to the Closing Date.

          6.5.2. Purchaser shall have delivered all of the Purchaser's Documents
     to be executed by Purchaser set forth in SECTION 6.3 and shall have
     performed all of the covenants, undertakings and obligations in all
     respects, and complied with all conditions required by this Agreement, to
     be performed or complied with by Purchaser at or prior to the Closing.

          6.5.3. At the Closing Date, Seller shall have received a certificate,
     dated the Closing Date, signed by Purchaser to the effect set forth in
     SUBSECTION 6.5.1, certifying that Purchaser has received all necessary
     internal approvals and authorizations necessary in connection with its
     purchase of the Property from Seller pursuant to this Agreement, and
     stating that the conditions specified in this SECTION 6.5 have been
     satisfied at the Closing Date, in substantially the form attached hereto as
     EXHIBIT L.

          6.5.4. No Law or Order shall have been enacted, entered, issued,
     promulgated or enforced by any Governmental Entity between the Due

                                       25
<Page>

     Diligence Expiration Date and the Closing which prohibits or restricts the
     use of the Property as laboratory and office facilities as contemplated by
     this Agreement. No Governmental Entity shall have notified any party to
     this Agreement that consummation of the transactions contemplated by this
     Agreement would constitute a violation of any Law of any jurisdiction or
     that it intends to commence proceedings to restrain or prohibit such
     transactions or force divestiture or rescission, unless such Governmental
     Entity shall have withdrawn such notice and abandoned any such proceedings
     prior to the time which otherwise would have been the Closing Date.

     6.6. GRACE AND CURE PERIODS.

     Notwithstanding any other provisions set forth herein, in the event that a
party to this Agreement shall not have satisfied any condition precedent to the
Closing on the Closing Date the other party shall notify the party required to
satisfy the condition of the action that is necessary to satisfy the outstanding
condition and the party required to satisfy the condition shall then have one
(1) Business Day to satisfy said condition. In the event that a notice is given
pursuant to the preceding sentence the Closing shall be automatically extended
for one (1) Business Day.

7. REPRESENTATIONS AND WARRANTIES

     7.1. PURCHASER'S REPRESENTATIONS AND WARRANTIES.

     In order to induce Seller to enter into the transactions provided for in
this Agreement, Purchaser hereby represents and warrants to Seller that as of
the date of this Agreement:

          7.1.1. Purchaser is a corporation duly organized and validly existing
     under the laws of the State of Delaware, is duly qualified to do business
     in all jurisdictions where such qualification is necessary to carry on its
     business as now conducted, and is duly qualified in the Commonwealth of
     Massachusetts, and has the power to acquire, own and operate the Property.
     Purchaser has the power to enter into the transactions contemplated by this
     Agreement and to execute, deliver and perform this Agreement, and the
     Purchaser's Documents. The execution, delivery and performance by Purchaser
     of this Agreement and the other Purchaser's Documents has been duly
     authorized by all necessary requisite entity action of Purchaser, and this
     Agreement is, and at the Closing the other Purchaser's Documents will, when
     executed and delivered by Purchaser, constitute the legal, valid and
     binding obligations of Purchaser enforceable against Purchaser in
     accordance with their respective terms and provisions, subject to
     applicable

                                       26
<Page>

     bankruptcy and other like laws affecting the rights of contractual parties
     and creditors generally, and the exercise of judicial or administrative
     discretion in accordance with general equitable principles (whether such
     enforceability is considered in a proceeding in equity or at law).

          7.1.2. There is no action, suit, notice of violation, proceeding or
     investigation pending or, to the knowledge of Purchaser, threatened against
     or affecting Purchaser or any of its respective properties before or by any
     Governmental Entity which (i) challenges the legality, validity or
     enforceability of any of the documents relating to the transaction provided
     for in this Agreement, or (ii) could (individually or in the aggregate)
     materially and adversely affect the ability of the Purchaser to perform its
     obligations under this Agreement and the Purchaser's Documents.

          7.1.3. No authorization, consent, approval, waiver, license,
     qualification or formal exemption from, or other action of, nor any filing,
     declaration, qualification or registration with, any Governmental Entity or
     any securities exchange is required in connection with the execution,
     delivery, observance or performance by Purchaser of this Agreement, or any
     of the Purchaser's Documents, or any of the transactions provided for
     herein.

          7.1.4. There has not been filed by or against Purchaser, or any
     corporation, partnership, or other entity with respect to which Purchaser
     is a principal shareholder, controlling person, general partner or managing
     member, as the case may be, a petition in bankruptcy or insolvency
     proceedings or for reorganization, or for the appointment of a receiver or
     trustee, nor has any such entity made an assignment for the benefit of
     creditors or filed a petition for an arrangement or entered into an
     arrangement with creditors or admitted in writing the inability to pay its
     debts as they become due.

          7.1.5. The execution and delivery of this Agreement and the
     Purchaser's Documents, and the transactions provided for herein and
     therein, respectively, and compliance with or fulfillment of the terms
     hereof and thereof, will not (a) conflict with, result in a breach of, or
     constitute a default under, any of the organizational documents of
     Purchaser, (b) require any consent, approval or notice under, or conflict
     with or result in the breach of, constitute a default or accelerate any
     right under, any note, bond, mortgage, license, indenture or loan or credit
     agreement, or any other agreement or instrument, to which Purchaser is a
     party or by which any of Purchaser's respective properties is bound, or (c)
     violate any provision of any Law presently in

                                       27
<Page>

     effect or in effect at the Closing Date having applicability to Purchaser
     or any of its properties including, without limitation, the Property.

     7.2. SELLER'S REPRESENTATIONS AND WARRANTIES.

     In order to induce Purchaser to enter into the transactions provided for in
this Agreement, Seller hereby represents and warrants to Purchaser that as of
the date of this Agreement:

          7.2.1. Seller is a limited liability company duly organized and
     validly existing under the laws of the State of Delaware, is duly qualified
     to do business in all jurisdictions where such qualification is necessary
     to carry on its business as now conducted, and is duly qualified in the
     Commonwealth of Massachusetts and has full power and authority to enter
     into the transactions contemplated by this Agreement and to execute,
     deliver and perform this Agreement and the Seller's Documents. The
     execution, delivery and performance by Seller of this Agreement and the
     other Seller's Documents have been duly authorized by all necessary
     requisite entity action of Seller and this Agreement is, and at the Closing
     the other Seller's Documents will, when executed and delivered by Seller,
     constitute the legal, valid and binding obligations of Seller enforceable
     against Seller in accordance with their respective terms and provisions,
     subject to applicable bankruptcy and other like laws affecting the rights
     of contractual parties and creditors generally, and the exercise of
     judicial or administrative discretion in accordance with general equitable
     principles (whether such enforceability is considered in a proceeding in
     equity or at law).

          7.2.2. There is no action, suit, proceeding or investigation pending
     or, to the knowledge of Seller, threatened against or affecting Seller or
     any of its respective properties before or by any Governmental Entity which
     (i) challenges the legality, validity or enforceability of any of the
     documents relating to the transaction provided for by this Agreement, or
     (ii) could (individually or in the aggregate) materially and adversely
     affect the ability of the Seller to perform its obligations under this
     Agreement and the Seller's Documents.

          7.2.3. No authorization, consent, approval, waiver, license,
     qualification or formal exemption from, or other action of, nor any filing,
     declaration, qualification or registration with, any Governmental Entity or
     any securities exchange is required in connection with the execution,
     delivery, observance or performance by Seller of this Agreement, or any of
     the Seller's Documents, or any of the transactions provided for herein.

                                       28
<Page>

          7.2.4.  There has not been filed by or, to Seller's Knowledge, against
     Seller a petition in bankruptcy or insolvency proceedings or for
     reorganization, or for the appointment of a receiver or trustee, nor has
     Seller made an assignment for the benefit of creditors or filed a petition
     for an arrangement or entered into an arrangement with creditors or
     admitted in writing the inability to pay its debts as they become due.

          7.2.5.  The execution and delivery of this Agreement by Seller and the
     Seller's Documents by Seller, and Seller's compliance with or fulfillment
     of the terms hereof and thereof, will not (a) conflict with, or result in a
     breach of, or constitute a default under, any of the organizational
     documents of Seller, (b) require any consent, approval or notice under, or
     conflict with or result in the breach of, constitute a default or
     accelerate any right under, any note, bond, mortgage, license, indenture or
     loan or credit agreement, or any other agreement or instrument, to which
     Seller is a party or by which any of Seller's respective properties is
     bound, or (c) violate any provision of any Law presently in effect or in
     effect at the Closing Date having applicability to Seller or any of its
     properties including, without limitation, the Property.

          7.2.6.  As of the date hereof, there are no written agreements in
     force or rights of occupancy or possession, for the use, lease, sublease or
     occupancy of space in or at the Property or any portion thereof (whether or
     not the terms thereof have commenced) to which the Seller or any of its
     designees are a party or are bound as landlord other than as listed in
     EXHIBIT B hereto.

          7.2.7.  There are no pending real property tax reduction or abatement
     proceedings affecting the Real Property.

          7.2.8.  (a) There are no material Service Contracts with respect to
     the Property other than those listed on EXHIBIT E attached hereto. Such
     Service Contracts are accurately and completely set forth in EXHIBIT E, and
     the copies thereof furnished by Seller to Purchaser are true and complete.

                  (b) There are no material claims or any basis for material
     claims in respect of the Property or its operation by any of the parties to
     such Service Contracts.

          7.2.9.  Seller has not, as of the date of this Agreement, received
     written notice from any Governmental Entity with respect to any actual or
     threatened taking of the Property or any portion thereof for any public or
     quasi-public purpose by the exercise of the right of

                                       29
<Page>

     condemnation or eminent domain, and to Seller's Actual Knowledge, there are
     no such actions or proceedings pending, presently threatened or
     contemplated by any Governmental Entity.

          7.2.10. Except as may have been disclosed in writing to Purchaser
     prior to the date of the Agreement, there are no suits, actions or
     proceedings pending against or affecting the Property or any portion
     thereof before or by any court or administrative agency or officer, and to
     the Seller's Actual Knowledge, there are no such actions or proceedings
     threatened.

          7.2.11. To the Seller's Actual Knowledge, Seller has not received any
     notices from any insurer or its agent requiring performance of any work
     with respect to the Property or canceling or threatening to cancel any
     policy, which notices have not been discharged or resolved.

          7.2.12. To the Seller's Actual Knowledge, Seller has received no
     notice from any third party as to a material breach or violation by Seller
     nor, to the Seller's Actual Knowledge, is Seller in material breach or
     violation, of Seller's covenants and obligations under the Real Property
     Agreements.

          7.2.13. Except as listed on EXHIBIT N hereto to Seller's Actual
     Knowledge, Seller has not received, with respect to the Property, any
     written notices from any governmental agency or other third party of any
     violations or claimed violations of Laws, which have not been cured or
     corrected or which notices have not been rescinded.

          7.2.14. Seller has delivered to Purchaser true, correct and complete
     copies of all written environmental site assessments, reports and summaries
     and asbestos surveys (collectively, the "ENVIRONMENTAL REPORTS") described
     on EXHIBIT O. To Seller's Knowledge, the Environmental Reports are the only
     reports in Seller's possession regarding environmental matters and
     Hazardous Materials at the Real Property. Except as set forth on EXHIBIT O,
     Seller has not received any written Notice of any alleged claims relating
     to environmental matters or of the presence of any Hazardous Material on
     the Real Property which is not permitted by applicable Law.

     7.3.   SELLER'S KNOWLEDGE.

     All references in this Agreement to "SELLER'S ACTUAL KNOWLEDGE" or words of
similar import shall refer only to the current actual knowledge of Seller's
Representative and shall not be construed to refer to the knowledge of any other
officer, agent, or employee of, Seller, or any Affiliate of Seller, or to

                                       30
<Page>

impose or have imposed upon the Designated Representative any duty to
investigate the matters to which such knowledge, or the absence thereof,
pertains, including, but not limited to, the contents of the files, documents
and materials made available to or disclosed to Purchaser or the contents of
files maintained by the Designated Representative, the Seller, or the Affiliates
of any of them. There shall be no personal liability on the part of the
Designated Representative arising out of any representations or warranties made
herein.

     7.4.   SURVIVAL.

     Except as otherwise expressly provided in SECTION 7.6 or elsewhere in this
Agreement, no representations, warranties, covenants or other obligations of
Seller set forth in this Agreement shall survive the Closing and delivery of the
Deed to the Real Property, and except as to representations and warranties which
survive the Closing, no action based thereon shall be commenced after the
Closing.

     7.5.   UNTRUE REPRESENTATION OR WARRANTY.

     If any representation or warranty made herein by Purchaser or Seller is
untrue, inaccurate or incorrect at any time prior to Closing, the provisions of
this SECTION 7.5 shall govern. If any party discovers prior to the Closing that
any such representation or warranty is untrue, inaccurate or incorrect it shall
notify the other party within three (3) Business Days of its discovery of same,
failing which said discovering party shall have no right to make any claim in
connection with said representation or warranty. If the party having made such
representation or warranty is Seller, then the Purchaser, as its sole remedy for
any such breach, shall elect either (a) to waive (but without releasing Seller
from its covenants made in SECTIONS 7.6 and 7.7 hereof) said breach of this
Agreement and consummate the sale and purchase of the Property, without any
reduction of or credit against the Purchase Price, or (b) to require Seller to
either (1) cure said breach to Purchaser's reasonable satisfaction prior to the
Closing; or (2) provide Purchaser with a credit sufficient in Purchaser's
reasonable discretion to compensate Purchaser for said breach, which credit
amount shall be set forth in the notice. If Purchaser does not waive such breach
pursuant to clause (a) above or if Seller fails to comply with the provisions of
clause (b) above, Purchaser may terminate this Agreement by written notice given
to Seller on the Closing Date, in which event this Agreement will be terminated,
Purchaser shall be entitled to the immediate return of the Deposit and Seller
shall so instruct the Title Company in writing and thereafter neither party will
have any further rights or obligations hereunder except as provided in any
Section hereof that by its terms expressly provides that it survives any
termination of this Agreement. If however the breaching party is the Purchaser
and the Purchaser is unwilling or unable to so cure any such breach, then the
Seller, as its sole

                                       31
<Page>

remedy in respect of any such breach of Purchaser, shall elect either to (c)
waive (but without releasing Purchaser from its covenants made in SECTION 7.6
hereof) such breach of Purchaser and consummate the sale and purchase of the
Property, or (d) terminate this Agreement by written notice given to Purchaser
at the Closing Date in which event this Agreement shall be terminated, Seller
shall be entitled to the Deposit as liquidated damages in accordance with
SECTION 11.1 and Purchaser shall so instruct the Title Company in writing and
thereafter neither party shall have any further rights or obligations hereunder
except as provided in any Section hereof that by its terms expressly provides
that it survives any termination of this Agreement.

     7.6.   SURVIVAL PERIOD.

     The representations and warranties contained in ARTICLE 7 and in the
certificates delivered by (i) Seller pursuant to SECTION 6.4.2 and (ii)
Purchaser pursuant to SECTION 6.5.3, and the limitations on Seller's liability
in SECTION 7.7 hereof, shall survive the Closing, with said representations and
warranties surviving the execution and delivery of the Deed for a period of
twelve (12) months following the Closing Date (the "REPRESENTATION EXPIRATION
DATE"), and no action based thereon shall be commenced either by Seller or
Purchaser following the Representation Expiration Date; PROVIDED THAT, if
written notice asserting a claim for breach of any such representation or
warranty shall have been given by either party prior to the Representation
Expiration Date and an action based thereon shall have been commenced prior to
the expiration of the twelfth (12th) month following the Representation
Expiration Date, such representation and warranty and any right to
indemnification for breach thereof, shall survive, to the extent of such claim
only, until such claim is resolved. The indemnification and other agreements of
the parties set forth herein which expressly provide that they shall survive the
Closing or the earlier termination of this Agreement shall not expire, except as
specifically set forth in those Sections. Any rights a party may have in the
event such party terminates this Agreement pursuant to the terms hereof shall
survive such termination.

     7.7.   MATERIAL MISREPRESENTATIONS.

     Anything in this Agreement to the contrary notwithstanding, (i) Seller
shall only be liable to Purchaser hereunder for untrue, inaccurate or incorrect
representations and warranties made herein or in any of Seller's Documents, but
only if such representations or warranties are untrue, inaccurate or incorrect
in any material respect ("MATERIAL MISREPRESENTATIONS"), and where the actual
direct damages to Purchaser for all such Material Misrepresentations of Seller
made herein or in any other of Seller's Documents, in the aggregate, when taken
together with all other Material Misrepresentations, exceeds Two Hundred
Thousand Dollars ($200,000), and

                                       32
<Page>

(ii) the maximum aggregate liability of Seller, and the maximum aggregate amount
which may be awarded to and collected by Purchaser, for all Material
Misrepresentations of Seller made herein or in any other of Seller's Documents
shall not exceed the lesser of (A) the actual, direct damages proximately caused
by any such Material Misrepresentations of Seller, and (B) Three Million Dollars
($3,000,000).

8. PURCHASER'S COVENANTS

     8.1.   CONFIDENTIALITY.

     Purchaser hereby covenants as follows:

          8.1.1.  Purchaser covenants and agrees that it shall not communicate
     the terms or any aspect of this transaction to any Person prior to the
     Closing except for Purchaser's advisors, attorneys, accountants and lenders
     (the "PURCHASER PARTIES"), on condition that said Purchaser Parties first
     agree to respect the obligations of Purchaser set forth in this SECTION
     8.1. The foregoing confidentiality obligations shall not apply to the
     extent that such (a) information (i) is a matter of public record or is
     provided in other sources readily available to the real estate industry
     other than as a result of disclosure by Seller or Broker, (ii) was
     available to Purchaser on a non-confidential basis prior to its disclosure
     to Purchaser or the Purchaser Parties, (iii) becomes available to Purchaser
     or the Purchaser Parties from a source known to Purchaser or the Purchaser
     Parties not having a duty of confidentiality with regard to the information
     or (iv) was or is independently developed by Purchaser or the Purchaser
     Parties from non-confidential sources, or (b) disclosure is compelled by
     Law. Notwithstanding anything contained herein to the contrary, in the
     event Purchaser is required by Law to disclose any confidential documents
     or information, prior to disclosing same, Purchaser shall notify Seller in
     writing of such required disclosure, shall exercise all commercially
     reasonable efforts to preserve the confidentiality of the confidential
     documents or information, as the case may be, including, without
     limitation, reasonably cooperating with Seller to obtain an appropriate
     Order or other reliable assurance that confidential treatment will be
     accorded such confidential documents or information, as the case may be, by
     such tribunal or authority and shall disclose only that portion of the
     confidential documents or information which it is legally required to
     disclose. If this Agreement is terminated such confidentiality shall be
     maintained and Purchaser and the Purchaser Parties will destroy or deliver
     to Seller, upon request, all documents and other materials, and all copies
     thereof, obtained by Purchaser and the Purchaser Parties in connection with
     this Agreement that are subject to such confidence, with

                                       33
<Page>

     any such destruction confirmed by Purchaser and the Purchaser Parties to
     Seller in writing. The provisions of this SECTION 8.1.1 shall survive
     Closing or termination of this Agreement and any other prior agreements
     between the parties concerning confidentiality.

          8.1.2.  Neither Purchaser nor Seller shall announce or disclose
     publicly the terms or provisions hereof without the prior written approval
     of the other party, except as such disclosure may be required by Law and
     except that this provision shall not prohibit either party from disclosing
     such terms or provisions to its Purchaser Parties.

          8.1.3.  The provisions of this Agreement relating to confidentiality
     shall supersede the provisions of that certain confidentiality letter
     agreement dated July 13, 2000 between Seller and Purchaser, and any other
     prior agreements between the parties concerning confidentiality.

     8.2.   NON-RELIANCE ON REPRESENTATIONS AND WARRANTIES.

     Purchaser affirms that, except as expressly provided for in this Agreement,
Seller has not made nor has Purchaser relied upon any representation, warranty
or promise with respect to the subject matter of this Agreement, including,
without limitation, any warranties or representations, express or implied, as to
(a) the value, use, tax status or physical condition of the Property, or any
part thereof, repairs thereto, income therefrom, expenses of maintenance or
operation thereof, or as to the accuracy of any survey or plans thereof, (b) the
adequacy of any plans, specifications or site plans for the Real Property or
their compliance with Law, (c) any Space Leases or tenancies of any part of the
Real Property, or regulations affecting the Property, (d) the availability of
any financing for the purchase, alteration or operation of the Property from any
source, including but not limited to, State, City or Federal governments or any
institutional lender, (e) the applicability or effect of or compliance with any
building, subdivision, zoning, land use, securities, ecology, environmental
protection and like Laws of Governmental Entities, including those of any and
all regulatory agencies and administrative officials having or asserting
jurisdiction over the Property, (f) habitability, merchantability or fitness for
a particular purpose, (g) title, (h) latent or patent physical or environmental
conditions, or (i) valuation.

     8.3.   PURCHASER INDEMNITY.

     Purchaser hereby agrees to indemnify, defend, and hold Seller, its counsel,
the Broker (hereinafter defined), its sales agents, and each partner, officer,
director, employee, agent or attorney of Seller, its counsel, Broker, or its
sales agents, and any other party related in any way to the foregoing (all of

                                       34
<Page>

which parties are herein collectively called the "Seller Parties"), free and
harmless from and against any and all costs, loss, damages and expenses, of any
kind or nature whatsoever (including attorneys fees' and costs), arising out of
damage to persons or property arising out of or resulting from the entry and/or
the conduct of activities upon the Property by Purchaser, its agents,
contractors and/or subcontractors in connection with the inspections,
examinations, testings and investigations of the Property conducted at any time
prior to the Closing, which indemnity shall survive the Closing (and not be
merged therein) or any earlier termination of this Agreement. The foregoing
indemnity shall not be deemed to apply to any actual or alleged loss or damage
to the value of any of the Property or any loss of the sale contemplated by this
Agreement, to the extent due solely from (i) any test results, studies, or
evaluations made by Purchaser (or by any of Purchaser's consultants to
Purchaser) being unfavorable, or (ii) Purchaser's decision not to proceed with
the purchase of the Property. The provisions of this Section 8.3 shall survive
the Closing or any termination of this Agreement.

     8.4.   SURVIVAL.

     The covenants of Purchaser in this ARTICLE 8 shall survive the Closing in
accordance with their terms and shall not be merged therein.

9. SELLER'S COVENANTS

Seller hereby covenants as follows:

     9.1.   SELLER'S OPERATION OF PROPERTY.

     Except to the extent Seller is relieved of such obligations by ARTICLE 12
hereof, between the date hereof and the Closing Date, Seller shall maintain and
keep the Property in good order and condition, but in no event shall Seller be
obligated to maintain and keep the Property to a standard greater than that
which is consistent with Seller's past practices with respect to the Property.
From the date hereof through the Closing Date, Seller (a) will advise Purchaser
of any written notice Seller receives from any Governmental Entity relating to
the violation of any Law regulating the condition or use of the Property, and
(b) will promptly notify Purchaser of any material change affecting the Property
of which Seller has Actual Knowledge.

     9.2.   ACCESS.

     Prior to the Closing, Seller shall allow Purchaser or Purchaser's
Representatives access to the Property upon reasonable prior notice at
reasonable times provided such access does not interfere with the operation of
the Property or the rights of any tenant or occupant of the Property and subject
to Purchaser's indemnification agreement set forth in SECTION 8.3 and

                                       35
<Page>

provided further that Seller or any representative of Seller shall have the
right to accompany Purchaser and Purchaser's Representatives whenever they are
on the Property.

     9.3.   NO MARKETING.

     Seller agrees not to offer to sell, negotiate for or solicit or otherwise
pursue any other offers for the purchase of the Property or any part thereof
from any party other than Purchaser for the period of time beginning immediately
after this Agreement is fully executed and ending on the termination of this
Agreement, as applicable, by either party hereto in accordance with this
Agreement or the Closing, as applicable. Purchaser agrees not to offer to
purchase, negotiate for or solicit or otherwise pursue any other offers for the
sale of real property located within a one hundred (100) mile radius of the
Property for the period of time beginning immediately after this Agreement is
fully executed and ending on the termination of this Agreement by either party
hereto in accordance with this Agreement or the Closing, as applicable.

10. COVENANTS OF SELLER AND PURCHASER

     10.1.  PRESS RELEASES.

     Seller and Purchaser each hereby covenant that at, prior to or immediately
after the Closing neither Seller nor Purchaser shall issue any press release or
public statement (a "PRESS RELEASE") with respect to the transaction provided
for by this Agreement without the prior consent of the other, except to the
extent required by Law or by any securities exchange on which Purchaser's stock
is listed. If either Seller or Purchaser is required by Law to issue a Press
Release, such party shall, at least two (2) Business Days prior to the issuance
of the same, deliver a copy of the proposed Press Release to the other party for
its review and approval within such two (2) Business Day period, such approval
not to be unreasonably withheld.

     10.2.  BROKERS.

     Seller and Purchaser expressly acknowledge that Spaulding & Slye and Grubb
& Ellis (collectively, the "BROKER") have acted as Seller's exclusive brokers
with respect to the transaction contemplated herein and with respect to this
Agreement, and that Seller shall pay any brokerage commissions due to Broker in
accordance with separate agreements between Seller and each Broker. Seller and
Purchaser each represents and warrants to the other that it has not dealt with
any other broker in this transaction and each agrees to hold harmless the other
and indemnify the other from and against any and all damages, costs or expenses
(including, but not limited to, reasonable attorneys' fees and disbursements)
suffered by the indemnified party as a result of acts of

                                       36
<Page>

the indemnifying party that would constitute a breach of its representation and
warranty in this Section.

     10.3.  ACCESS TO RECORDS.

     Where there is a legitimate reason (including, without limitation, a tax
audit, other governmental inquiry, or actual or prospective claim by or against
either Seller or Purchaser, or to which Seller or Purchaser may become a party)
for Seller or Purchaser to require access to records or other information
relating to the Property that is in the possession or control of the other
party, and if providing such access would not adversely affect the party whose
records are being sought (in the good faith judgment of such party), each party
will, subject to the confidentiality covenants between Purchaser and Seller in
SECTION 8.1.1 hereof, allow the other reasonable access to such records and
information at their then-current location (or such other location as the party
in possession of such records or information may reasonably designate), in order
to analyze and/or copy the same (at the requesting party's sole cost and
expense), for use solely for the purposes for which the same are being
requested. In any case in which a party hereto desires to obtain any records or
information pursuant to this Section, such party shall notify the other in
writing of such request, setting forth in such notice the purposes for which
such records and information are being requested and the expected use thereof
(including, if applicable, the nature of any claim or other proceeding in which
the same will be used and the parties thereto), and the party receiving such
request may, as a condition to granting the same, require that the requesting
party enter into an agreement protecting the confidentiality of such records and
information. In no event shall a party be obligated to provide access to records
or other information under this Section in connection with any litigation,
claim, or dispute between Purchaser and Seller, or in which Purchaser and Seller
are or may become adverse parties, other than in accordance with applicable
discovery and evidentiary rules and procedures applicable to such matter, and no
access to or disclosure of records or information shall be required hereunder if
the same would or reasonably could result in the loss of any attorney-client
privilege or other applicable evidentiary privileges that may be applicable to
such records or information. Each party shall maintain its records for use under
this Section for a period of not less than three (3) years after the Closing
Date; PROVIDED THAT prior to such date no such records shall be destroyed unless
the holder provides the other party hereunder with at least ninety (90) days
prior written notice. Upon receipt of notice of destruction, the non-holder
shall have the option, at its sole cost and expense, to take possession of the
records set for destruction, in which case the non-holder shall assume all
further cost of storage and destruction of such records. The terms of this
SECTION 10.3 shall survive the Closing and not be merged therein.

                                       37
<Page>

     10.4.  NON-COMPLIANCE.

     Purchaser shall give prompt notice to Seller, and Seller shall give prompt
notice to Purchaser, of (a) the occurrence, or failure to occur, of any event
that causes any representation or warranty contained in any document relating to
this Agreement to be untrue or inaccurate in any material respect at any time
from the date of this Agreement to the Closing Date, and (b) any failure of
Purchaser, on the one hand, or Seller, on the other hand, to comply with or
satisfy, in any material respect, any covenant, condition or agreement to be
complied with or satisfied by it under any document relating to this Agreement.

     10.5.  SURVIVAL.

     The provisions of this ARTICLE 10 shall survive the Closing (and not be
merged therein) or earlier termination of this Agreement.

11. FAILURE OF PERFORMANCE

     11.1.  PURCHASER DEFAULT.

     If, on the Closing Date, (i) Purchaser is in default of any of its
obligations hereunder, or (ii) any of Purchaser's representations or warranties
made herein are untrue, inaccurate or incorrect in any material respect, or
(iii) any condition to the obligation of Seller to close hereunder has not been
satisfied as a result of the failure by Purchaser to perform its obligations
under this Agreement, or otherwise, then Seller may elect as its sole remedy,
after first having given Purchaser notice and one (1) Business Day's opportunity
to cure the same, either to (x) terminate this Agreement by written notice to
Purchaser and the Escrow Agent, promptly after which the Deposit with any
accrued interest thereon shall be paid over to Seller, (y) waive such default,
misrepresentation or condition and proceed to close the transaction under this
Agreement, or (z) seek specific performance of this Agreement. If this Agreement
is so terminated, then Seller shall be entitled immediately to the proceeds of
the Deposit plus any interest accrued thereon as liquidated damages (and
Purchaser shall so instruct the Title Company in writing), and thereafter
neither party to this Agreement shall have any further rights or obligations
hereunder other than any arising under any Section herein which expressly
provides that it survives the termination of this Agreement. The amount of
liquidated damages set forth in this SECTION 11.1 shall be for all loss, damage
and expense suffered by Seller, including, without limitation, the loss of its
bargain, it being agreed that Seller's damages are difficult if not impossible
to ascertain.

                                       38
<Page>

     11.2.  SELLER DEFAULT.

     If, on the Closing Date, (i) Seller is in default of any of its obligations
hereunder, (ii) any of Seller's representations or warranties made herein are
untrue, inaccurate or incorrect in any material respect, or (iii) any condition
to the obligation of Purchaser to close hereunder has not been satisfied as a
result of the failure by Seller to perform its obligations under this Agreement,
or otherwise, then Purchaser may elect, as its sole remedy, after first having
given Seller notice and one (1) Business Day's opportunity to cure the same,
either to (x) terminate this Agreement by written notice to Seller and the
Escrow Agent, promptly after which the Deposit plus any interest accrued thereon
shall be returned to Purchaser, (y) waive such default, misrepresentation or
condition and proceed to close the transaction under this Agreement without any
reduction of or credit against the Purchase Price, or (z) seek specific
performance of this Agreement. If this Agreement is so terminated, then
Purchaser shall be entitled immediately to the proceeds of the Deposit plus any
interest accrued thereon as liquidated damages (and Seller shall so instruct the
Title Company in writing), and thereafter neither party to this Agreement shall
have any further rights or obligations hereunder other than any arising under
any Section herein which expressly provides that it survives the termination of
this Agreement.

12. CONDEMNATION/CASUALTY

     12.1.  CONDEMNATION.

     If, prior to the Closing Date, all or any Significant Portion (as
hereinafter defined) of the Property is taken by eminent domain (or is the
subject of a pending taking which has not yet been consummated), Seller shall
notify Purchaser in writing of such fact promptly after obtaining knowledge
thereof and provide to Purchaser all information, to the extent in Seller's
possession or control, regarding such takings, and Purchaser shall have the
right to terminate this Agreement by giving written notice to Seller no later
than ten (10) Business Days after the giving of Seller's notice, and the Closing
Date shall be extended, if necessary, to provide sufficient time for Purchaser
to make such election. The failure by Purchaser to so elect in writing to
terminate this Agreement within such ten (10) calendar day period shall be
deemed an election not to terminate this Agreement. For purposes hereof', a
"SIGNIFICANT PORTION" of the Property shall mean such portion as (i) shall have
a value, as reasonably determined by Seller, in excess of One Million Dollars
($1,000,000.00), (ii) shall materially impair access to or parking at the
Property, or (iii) the suitability of the Property for use as a laboratory
office facility. If Purchaser elects to terminate this Agreement as aforesaid,
the provisions of SECTION 12.6 shall apply.

                                       39
<Page>

     12.2.  CONDEMNATION AWARD.

     If (a) Purchaser does not elect to terminate this Agreement as aforesaid in
the event all or any Significant Portion of the Property is taken, or if (b) a
portion of the Property not constituting a Significant Portion of the Property
is taken or becomes subject to a pending taking, by eminent domain, there shall
be no abatement of the Purchase Price; PROVIDED, HOWEVER, that, at the Closing,
Seller shall pay to Purchaser the amount of any award for or other proceeds on
account of such taking which have been actually paid to Seller prior to the
Closing Date as a result of such taking and, to the extent such award or
proceeds have not been paid, Seller shall assign to Purchaser at the Closing
(without recourse to Seller) the rights of Seller to, and Purchaser shall be
entitled to receive and retain, all awards for the taking of the Property or
such portion thereof.

     12.3.  CASUALTY.

     In the event the Property is damaged or destroyed by fire or other casualty
prior to the Closing Date, Seller shall notify Purchaser in writing of such fact
promptly after obtaining knowledge thereof and provide to Purchaser all such
information as Seller may have in its possession or control regarding the extent
and nature of such casualty. If any such damage or destruction (a) is caused by
an insured casualty, and (b) would cost less than or equal to Two Million
Dollars ($2,000,000.00) to repair or restore, then this Agreement shall remain
in full force and effect and Purchaser shall acquire the Property upon the terms
and conditions set forth herein. In such event, unless prior to the Closing
Seller restores the damaged Property to its original condition, Purchaser shall
receive a credit against the Purchase Price equal to the deductible amount
applicable under Seller's casualty insurance policy, and Seller shall assign to
Purchaser all of Seller's right, title and interest in and to all proceeds of
insurance on account of such damage or destruction. In the event the Property is
damaged or destroyed prior to the Closing Date by an insured casualty and as a
result the cost of repair or restoration would cost more than Two Million
Dollars ($2,000,000.00), then, notwithstanding anything to the contrary set
forth above in this Section, Purchaser shall have the right, at its election,
either (i) to terminate this Agreement or (ii) to proceed to purchase the
Property in accordance with the terms of this Agreement. Purchaser shall have
ten (10) calendar days after Seller notifies Purchaser that a casualty has
occurred to make such election by delivery to Seller of a written election
notice (the "ELECTION NOTICE") and the Closing Date shall be extended, if
necessary, to provide sufficient time for Purchaser to make such election. The
failure by Purchaser to deliver the Election Notice within such ten (10) day
calendar period shall be deemed an election not to terminate this Agreement. In
the event that Purchaser does not elect to terminate this Agreement as set forth
above, this Agreement shall remain in

                                       40
<Page>

full force and effect and unless the Seller shall have repaired the Property as
herein described at the Closing, Seller shall assign to Purchaser all of
Seller's right, title and interest in and to any and all proceeds of insurance
on account of such damage or destruction, if any, and, if the casualty was an
insured casualty, Purchaser shall receive a credit against the Purchase Price
equal to the deductible amount under Seller's casualty insurance policy.

     12.4.  UNINSURED CASUALTY.

     In the event the Property is damaged or destroyed prior to the Closing Date
and such damage or destruction (a) is caused by an uninsured casualty, and (b)
would cost less than Five Hundred Thousand Dollars ($500,000.00) to repair or
restore, then this Agreement shall remain in full force and effect and Purchaser
shall acquire the Property upon the terms and conditions set forth herein. In
such event, at Seller's election either (i) Purchaser shall receive a credit
against the Purchase Price equal to the amount required to repair such damage or
destruction, or (ii) if Seller reasonably determines that the damage or
destruction can be repaired prior to Closing, Seller shall repair the Property
to substantially the same condition as existed prior to the damage or
destruction. In the event the Property is damaged or destroyed prior to the
Closing Date by uninsured casualty and the cost of repair or restoration would
equal or exceed Five Hundred Thousand Dollars ($500,000.00), then,
notwithstanding anything to the contrary set forth above in this Section,
Purchaser shall have the right, at its election, either (i) to terminate this
Agreement, or (ii) proceed to close in accordance with the terms of this
Agreement. Purchaser shall have ten (10) calendar days after Seller notifies
Purchaser that an uninsured casualty has occurred to make such election by
delivery to Seller of an Election Notice. The failure by Purchaser to deliver
the Election Notice within such ten (10) calendar day period shall be deemed an
election not to terminate this Agreement. In the event Purchaser does not elect
to terminate this Agreement as set forth above, this Agreement shall remain in
full force and effect, and at the Closing, Purchaser shall receive a credit
against the Purchase Price equal to the amount required to repair such damage or
destruction but in no event shall such credit exceed Five Hundred Thousand
Dollars ($500,000.00).

     12.5.  SELLER INSURANCE.

     Seller shall maintain or cause the tenant under the Space Lease to maintain
the property insurance coverage currently in effect for the Property through the
Closing Date, which coverage is listed on EXHIBIT Q. Seller shall not be
obligated to assign to Purchaser any insurance policies in connection with the
Property at the Closing.

                                       41
<Page>

     12.6.  RETURN OF DEPOSIT.

     If this Agreement is terminated pursuant to SECTIONS 12.1, 12.3 or 12.4
hereof, Seller shall cause the Escrow Agent to promptly return the Deposit
together with any accrued interest thereon to Purchaser. Upon such return
neither party to this Agreement shall have any further rights or obligations
hereunder other than any arising under any Section herein which expressly
provides that it shall survive the termination of this Agreement.

     12.7.  PRIMACY OF AGREEMENT.

     The provisions of this ARTICLE 12 supersede the provisions of any
applicable statutory or decisional law with respect to the subject matter of
this ARTICLE 12.

13. SELLER'S AND PURCHASER'S ACTIONS PRIOR TO THE CLOSING

     13.1.  NEW AGREEMENTS.

     Between the date hereof and the Closing Date, Seller shall not enter into
any new service contract, equipment lease, lease, license, or occupancy
agreement which would be binding on Purchaser at Closing without Purchaser's
express prior written consent. Within ten (10) Business Days following the date
of this Agreement, Purchaser shall notify Seller of those Service Contracts
listed in EXHIBIT E attached hereto, and those Equipment Leases, if any, noted
in EXHIBIT D attached hereto and made a part hereof that it does not desire to
assume, and Seller shall send termination notices of such Service Contracts and
Equipment Leases at or prior to Closing, provided that Seller shall have
provided Purchaser with copies of all such Agreements by no later than the date
hereof.

14. NEW LEASES

     14.1.  EXECUTION OF NEW LEASES.

     After the date of this Agreement, Seller shall not, without Purchaser's
prior written consent in each instance enter into a new lease for space in the
Real Property (a "NEW LEASE").

     14.2.  AMENDMENT.

     Without the prior written consent of Purchaser, which shall not be
unreasonably withheld, no existing Space Lease shall be modified or amended.

                                       42
<Page>

15. NOTICES

     Any notice pursuant to this Agreement shall be given in writing by (a)
personal delivery, or (b) reputable national overnight delivery service with
proof of delivery, or (c) legible facsimile transmission sent to the intended
addressee at the address set forth below, or to such address or to the attention
of such other Person as the addressee shall have designated by written notice
sent in accordance herewith, and shall be deemed to have been given upon receipt
or refusal to accept delivery, or, in the case of facsimile transmission, as of
the date of the transmission provided that (i) an original of said facsimile is
also sent to the intended addressee by means described in clauses (a), or (b)
above, and (ii) if said facsimile is received by any party after 5:00 p.m. on
any Business Day it shall be deemed received by said party on the next Business
Day. Unless changed in accordance with the preceding sentence, the addresses for
notice given pursuant to this Agreement shall be as follows:

If to Seller:

     SPAULDING AND SLYE HAYDEN WOODS LLC
     c/o Spaulding and Slye Company
     255 State Street
     Boston, MA  02109
     Attention:  Mr. Peter A. Bailey
     TELEPHONE:  (617) 523-8000
     TELECOPIER: (617) 531-4295

With a copy to:

     Bernkopf, Goodman & Baseman, LLP
     125 Summer Street
     Boston, Massachusetts 02110
     ATTENTION:  David L. Doyle, Esq.
     TELEPHONE:  (617) 790-3000
     TELECOPIER: (617) 790-3300

IF TO PURCHASER:

     CUBIST PHARMACEUTICALS, INC.
     24 Emily Street
     Cambridge, MA  02139
     ATTENTION:  Mr. Tom Shea
     TELEPHONE:  (617) 576-4155
     TELECOPIER:  (617) 234-5592

                                       43
<Page>

With a copy to:

     Bingham Data LLP
     150 Federal Street
     Boston, MA 02110
     ATTENTION:  Henry S. Healy, Esq.
     TELEPHONE:  (617) 951-8271
     TELECOPIER: (617) 951-8736

16. TIME OF THE ESSENCE

     It is understood and agreed, any rule of law or equity to the contrary
notwithstanding, that time is of the essence of each and every provision of this
Agreement, whether or not so stated therein.

17. SUCCESSORS AND ASSIGNS

     This Agreement shall be binding upon and inure to the benefit of Seller and
Purchaser and their respective legal representatives, designees, successors and
assigns, PROVIDED THAT, except as provided in the next sentence, neither party
may assign, pledge or otherwise transfer its rights and obligations hereunder
without the prior written consent of the other party, which such party may
withhold in its sole discretion, and, without limiting either party's other
rights and remedies, any such assignment, pledge or transfer made without the
prior written consent of the other party shall be void and of no force and
effect. Notwithstanding the foregoing provisions, Purchaser shall have the right
to assign its rights and obligations under this Agreement to an Affiliate of
Purchaser, PROVIDED THAT (a) at least five (5) Business Days prior written
notice thereof is given by Purchaser to Seller, identifying Purchaser's
Affiliate by name and address, explaining the relationship by which such
assignee is an Affiliate of Seller, (b) the assignee shall assume all of the
obligations of Purchaser under the terms of this Agreement in writing, and (c)
the originally named Purchaser shall remain liable to Seller for all obligations
of the assignee under the terms of this Agreement.

18. MISCELLANEOUS PROVISIONS

     18.1.  MERGER.

     Except for the provisions of this Agreement which are explicitly stated to
survive the Closing, (a) none of the terms of this Agreement shall survive the
Closing, and (b) the delivery of the Deed and any other of Seller's Documents by
Seller and the acceptance thereof by Purchaser shall effect a merger, and be
deemed the full performance and discharge of every obligation on the part of
Purchaser and Seller to be performed hereunder.

                                       44
<Page>

     18.2.  ENTIRE AGREEMENT; WAIVER.

     This Agreement, together with Exhibits hereto, embodies and constitutes the
entire understanding between the parties with respect to the transaction
provided for by this Agreement and all prior agreements (including, without
limitation, any letter of intent), understandings, representations and
statements, oral or written, are merged into this Agreement. Neither this
Agreement nor any provision hereof may be waived, modified, amended, discharged
or terminated except by an instrument signed by the party against whom the
enforcement of such waiver, modification, amendment, discharge or termination is
sought, and then only to the extent set forth in such instrument. No waiver by
either party hereto of any failure or refusal by the other party to comply with
its obligations hereunder shall be deemed a waiver of any other or subsequent
failure or refusal to so comply.

     18.3.  GOVERNING LAW.

     This Agreement shall be governed by, and construed in accordance with, the
law of The Commonwealth of Massachusetts.

     18.4.  CAPTIONS.

     The captions in this Agreement are inserted for reference only and in no
way define, describe or limit the scope or intent of this Agreement or of any of
the provisions hereof. All Exhibits attached hereto shall be incorporated by
reference as if set out herein in full.

     18.5.  SUCCESSORS AND ASSIGNS.

     This Agreement shall be binding upon and shall inure to the benefit of the
parties hereto and their respective successors and permitted assigns.

     18.6.  SEVERANCE.

     If any term or provision of this Agreement or the application thereof to
any Persons or circumstances shall, to any extent, be invalid or unenforceable,
the remainder of this Agreement or the application of such term or provision to
Persons or circumstances other than those as to which it is held invalid or
unenforceable shall not be affected thereby, and each term and provision of this
Agreement shall be valid and enforced to the fullest extent permitted by law.

     18.7.  COUNTERPARTS.

     This Agreement may be executed in counterparts, each of which shall be an
original and all of which counterparts taken together shall constitute one and
the same agreement.

                                       45
<Page>

     18.8.  NO RECORDING.

     Seller and Purchaser each agrees that neither this Agreement nor any
memorandum or notice hereof shall be recorded and Purchaser agrees not to file
any notice of pendency or other instrument (other than a judgment filed by
Purchaser in connection with Purchaser's enforcement of its rights hereunder)
against any of the Property or any portion thereof in connection herewith.

     18.9.  ADDITIONAL DOCUMENTS.

     Subject to the terms and conditions herein provided, each of the parties
hereto shall execute and deliver such documents as the other party shall
reasonably request in order to consummate and make effective the transactions
provided for by this Agreement; PROVIDED, HOWEVER, that the execution and
delivery of such documents by such party shall not result in any additional
liability or cost to such party.

     18.10. INTERPRETATION.

     The parties acknowledge that each party and its counsel have reviewed this
Agreement and that the normal rule of construction to the effect that any
ambiguities are to be resolved against the drafting party shall not be employed
in the interpretation of this Agreement, or any amendment or Exhibit hereto.

     18.11. WAIVER OF JURY TRIAL.

     18.11.1.

     PURCHASER AND SELLER HEREBY WAIVE, TO THE FULLEST EXTENT PERMITTED BY LAW,
THE RIGHT TO TRIAL BY JURY IN ANY ACTION, PROCEEDING OR COUNTERCLAIM FILED BY
PURCHASER OR SELLER, WHETHER IN CONTRACT, TORT OR OTHERWISE, WHICH RIGHT OR
CLAIM RELATES DIRECTLY OR INDIRECTLY TO THIS AGREEMENT, ANY DOCUMENTATION
RELATED THERETO, OR ANY ACTS OR OMISSIONS IN CONNECTION WITH THIS AGREEMENT.
THIS WAIVER HAS BEEN AGREED TO AFTER CONSULTATION WITH LEGAL COUNSEL SELECTED BY
PURCHASER AND SELLER.

     This Waiver is agreed to:

          Purchaser's Initials ( )

          Seller's Initials    ( )

                                       46
<Page>

         [THE REMAINDER OF THIS PAGE HAS BEEN INTENTIONALLY LEFT BLANK.]

                                       47
<Page>

     IN WITNESS WHEREOF, each party hereto has caused this Agreement to be duly
executed on its behalf, under seal, the day and year first above written.

          SELLER:

          SPAULDING AND SLYE HAYDEN WOODS LLC

          By: Spaulding and Slye Real Estate Services Company, Inc., a Delaware
              corporation, its Managing Member

              By:    /s/ James B. Karman
                    ---------------------------------
              Name:  James B. Karman
                    -------------------------------
              Title: President
                    ------------------------------

          Taxpayer Identification No. 04-339-1286

          PURCHASER:

          CUBIST PHARMACEUTICALS, INC.

          By:    /s/ Thomas A. Shea
                ----------------------------------
          Name:  Thomas A. Shea
                ----------------------------------
          Title: CFO
                ----------------------------------

          Taxpayer Identification No. 22-319-2085

                                       Q-1

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