Document:

Loan and Security Agreement

 Exhibit 10.5 

Execution Copy 

LOAN AND SECURITY AGREEMENT 

Dated as of April 1, 2010 

among 

HORIZON PHARMA USA, INC. and 

NITEC PHARMA AG, 

(as Borrowers), 

HORIZON PHARMA, INC. 

(as Guarantor), 

KREOS CAPITAL III (UK) LIMITED 

(as Administrative Agent) 

and 
 The
Other Lenders Party Hereto 

 TABLE OF CONTENTS 

 

							
	 	 	 	    	 	  	Page
	1.	 	ACCOUNTING AND OTHER TERMS	  	1
			
	2.	 	LOAN AND TERMS OF PAYMENT	  	1
				
		 	2.1.	    	Promise to Pay	  	1
		 	2.2.	    	Term Loans	  	1
		 	2.3.	    	Fees	  	2
		 	2.4.	    	General Provisions Regarding Payments	  	3
		 	2.5.	    	Prepayment	  	3
		 	2.6.	    	Requirements of Law; Increased Costs	  	3
		 	2.7.	    	Taxes; Withholding, etc.	  	4
		 	2.8.	    	Defaulting Lenders	  	6
		 	2.9.	    	Evidence of Debt; Register; Lenders’ Books and Records; Term Loan Notes	  	6
			
	3.	 	CONDITIONS OF LOANS	  	7
				
		 	3.1.	    	Conditions Precedent to Initial Credit Extension	  	7
		 	3.2.	    	Conditions Precedent to Making of Second Term Loans	  	8
		 	3.3.	    	Conditions Precedent to all Credit Extensions	  	8
		 	3.4.	    	Covenant to Deliver	  	9
		 	3.5.	    	Procedures for Borrowing	  	9
			
	4.	 	CREATION OF SECURITY INTEREST	  	9
				
		 	4.1.	    	Grant of Security Interest	  	9
		 	4.2.	    	Priority of Security Interest	  	10
		 	4.3.	    	Authorization to File Financing Statements	  	11
			
	5.	 	REPRESENTATIONS AND WARRANTIES	  	11
				
		 	5.1.	    	Due Organization, Authorization; Power and Authority	  	11
		 	5.2.	    	Equity Interests and Ownership	  	11
		 	5.3.	    	No Conflict; Government Consents	  	11
		 	5.4.	    	Binding Obligation	  	11
		 	5.5.	    	Collateral	  	12
		 	5.6.	    	Adverse Proceedings, etc.	  	12
		 	5.7.	    	Financial Statements; Financial Condition	  	13
		 	5.8.	    	Solvency	  	13
		 	5.9.	    	Payment of Taxes	  	13
		 	5.10.	    	Environmental Matters	  	14
		 	5.11.	    	Material Contracts	  	14
		 	5.12.	    	Regulatory Compliance	  	14
		 	5.13.	    	Margin Stock	  	14
		 	5.14.	    	Subsidiaries; Investments	  	14
		 	5.15.	    	Employee Matters	  	14
		 	5.16.	    	Use of Proceeds	  	15
		 	5.17.	    	Full Disclosure	  	15
		 	5.18.	    	Patriot Act	  	15
		 	5.19.	    	Additional Representations and Warranties	  	15
		 	5.20.	    	10/20 Non-Bank Creditor Rules	  	15
			
	6.	 	AFFIRMATIVE COVENANTS	  	15
				
		 	6.1.	    	Government Compliance	  	15
		 	6.2.	    	Financial Statements, Reports, Certificates	  	16
		 	6.3.	    	Inventory; Returns; Maintenance of Properties	  	17
		 	6.4.	    	Taxes; Pensions	  	17
		 	6.5.	    	Insurance	  	18

  

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		 	6.6.	    	Operating Accounts	  	18
		 	6.7.	    	Protection of Intellectual Property Rights	  	19
		 	6.8.	    	Litigation Cooperation	  	19
		 	6.9.	    	Access to Collateral; Books and Records	  	19
		 	6.10.	    	Lenders Meetings	  	19
		 	6.11.	    	Environmental	  	19
		 	6.12.	    	Further Assurances	  	20
		 	6.13.	    	10/20 Non-Bank Creditor Rules	  	20
			
	7.	 	NEGATIVE COVENANTS	  	20
				
		 	7.1.	    	Dispositions	  	20
		 	7.2.	    	Changes in Business, Management, Ownership, or Business Locations	  	20
		 	7.3.	    	Mergers or Acquisitions	  	21
		 	7.4.	    	Indebtedness	  	21
		 	7.5.	    	Encumbrance	  	21
		 	7.6.	    	No Further Negative Pledges; Negative Pledge	  	21
		 	7.7.	    	Maintenance of Collateral Accounts	  	22
		 	7.8.	    	Distributions; Investments	  	22
		 	7.9.	    	Restrictions on Subsidiary Distributions.	  	22
		 	7.10.	    	Disposal of Subsidiary Interests	  	22
		 	7.11.	    	Transactions with Affiliates	  	22
		 	7.12.	    	Subordinated Debt	  	22
		 	7.13.	    	Amendments or Waivers of Organizational Documents	  	22
		 	7.14.	    	Fiscal Year	  	23
		 	7.15.	    	Compliance	  	23
		 	7.16.	    	Non-Guarantor Subsidiaries	  	23
			
	8.	 	GUARANTY	  	23
				
		 	8.1.	    	Guaranty of the Obligations	  	23
		 	8.2.	    	Payment By Guarantor	  	23
		 	8.3.	    	Liability of Guarantor Absolute	  	23
		 	8.4.	    	Waivers by Guarantor	  	25
		 	8.5.	    	Guarantor’s Rights of Subrogation, Contribution, etc.	  	25
		 	8.6.	    	Subordination of Other Obligations	  	26
		 	8.7.	    	Continuing Guaranty	  	26
		 	8.8.	    	Authority of Guarantor or Borrowers	  	26
		 	8.9.	    	Financial Condition of Borrowers	  	26
		 	8.10.	    	Bankruptcy, etc.	  	26
		 	8.11.	    	Discharge of Guaranty Upon Sale of Guarantor	  	27
			
	9.	 	EVENTS OF DEFAULT	  	27
				
		 	9.1.	    	Payment Default	  	27
		 	9.2.	    	Covenant Default	  	27
		 	9.3.	    	Material Adverse Change	  	27
		 	9.4.	    	Attachment; Levy; Restraint on Business	  	27
		 	9.5.	    	Insolvency	  	27
		 	9.6.	    	Other Agreements	  	28
		 	9.7.	    	Judgments	  	28
		 	9.8.	    	Misrepresentations	  	28
		 	9.9.	    	Subordinated Debt	  	28
		 	9.10.	    	Post-closing Agreement	  	28
			
	10.	 	RIGHTS AND REMEDIES UPON AN EVENT OF DEFAULT	  	28
				
		 	10.1.	    	Rights and Remedies	  	28
		 	10.2.	    	Power of Attorney	  	29
		 	10.3.	    	Protective Payments	  	29
		 	10.4.	    	Application of Payments and Proceeds Upon Default	  	29

  

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		 	10.5.	    	Administrative Agent’s Liability for Collateral	  	30
		 	10.6.	    	No Waiver; Remedies Cumulative	  	30
		 	10.7.	    	Demand Waiver	  	30
			
	11.	 	ADMINISTRATIVE AGENT	  	30
				
		 	11.1	    	Appointment of Administrative Agent	  	30
		 	11.2.	    	Powers and Duties	  	30
		 	11.3.	    	General Immunity	  	31
		 	11.4.	    	Administrative Agent Entitled to Act as Lender	  	32
		 	11.5.	    	Lenders’ Representations, Warranties and Acknowledgment	  	32
		 	11.6.	    	Right to Indemnity	  	32
		 	11.7.	    	Successor Administrative Agent	  	32
		 	11.8.	    	Collateral Documents and Guaranty	  	33
		 	11.9.	    	Withholding Taxes	  	33
			
	12.	 	NOTICES	  	33
			
	13.	 	CHOICE OF LAW, VENUE, AND JURY TRIAL WAIVER	  	35
			
	14.	 	GENERAL PROVISIONS	  	36
				
		 	14.1.	    	Successors and Assigns; Participations	  	36
		 	14.2.	    	Indemnification	  	38
		 	14.3.	    	Severability of Provisions	  	39
		 	14.4.	    	Correction of Loan Documents	  	39
		 	14.5.	    	Amendments and Waivers	  	39
		 	14.6.	    	Counterparts	  	40
		 	14.7.	    	Survival	  	40
		 	14.8.	    	Confidentiality	  	40
		 	14.9.	    	Attorneys’ Fees, Costs and Expenses	  	41
		 	14.10.	    	Right of Set-Off	  	41
		 	14.11.	    	Marshalling; Payments Set Aside	  	41
		 	14.12.	    	Obligations Several; Independent Nature of Lenders’ Rights	  	41
		 	14.13.	    	Electronic Execution of Documents	  	41
		 	14.14.	    	Captions	  	41
		 	14.15.	    	Construction of Agreement	  	42
		 	14.16.	    	Third Parties	  	42
		 	14.17.	    	No Fiduciary Duty	  	42
		 	14.18.	    	Borrower Liability	  	42
			
	15.	 	DEFINITIONS	  	43
				
		 	15.1.	    	Definitions	  	43

  

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 Execution Copy 

LOAN AND SECURITY AGREEMENT 

THIS LOAN AND SECURITY AGREEMENT (this “Agreement”), dated as of April 1, 2010 (the “Effective Date”)
by and among HORIZON PHARMA USA, INC., a Delaware corporation (formerly called HORIZON THERAPEUTICS, INC.) (“Horizon”), NITEC PHARMA AG, a company incorporated in Switzerland (“Nitec,” and together with Horizon,
each a “Borrower” and, collectively, jointly and severally, the “Borrowers”), HORIZON PHARMA, INC., a Delaware corporation (the “Guarantor,” and, together with the Borrowers, each a “Credit
Party” and, collectively, the “Credit Parties”), the Lenders listed on Appendix A hereto or otherwise party hereto from time to time, and KREOS CAPITAL III (UK) LIMITED (“Kreos”), as administrative
agent for the Lenders, or any successor administrative agent (in such capacity, the “Administrative Agent”), provides the terms on which the Lenders shall make, and Borrowers shall repay, the Credit Extensions (as hereinafter
defined). The parties agree as follows: 
 1. ACCOUNTING AND OTHER TERMS 

Except as otherwise expressly provided herein, all accounting terms not otherwise defined in this Agreement shall have the meanings
assigned to them in conformity with Applicable Accounting Standards. Calculations and determinations must be made following Applicable Accounting Standards. Capitalized terms not otherwise defined in this Agreement shall have the meanings set forth
in Section 15. All other terms contained in this Agreement, unless otherwise indicated, shall have the meaning provided by the Code to the extent such terms are defined therein. 

2. LOAN AND TERMS OF PAYMENT 

2.1. Promise to Pay. Borrowers hereby unconditionally promise to pay Lenders the outstanding principal amount of all Credit
Extensions and accrued and unpaid interest thereon as and when due in accordance with this Agreement. 
 2.2. Term Loans.

 (a) Availability. Subject to the terms and conditions of this Agreement, the Lenders severally agree that, on the
Effective Date, they shall make one or more Term Loans (each, a “First Term Loan,” and collectively, the “First Term Loans”) to Borrowers in the aggregate amount of Seven Million Dollars ($7,000,000), to be
allocated as between the Borrowers as the Borrowers shall determine; provided that the Borrowers shall advise the Administrative Agent of the allocation of such First Term Loans on or prior to the Funding Date for the First Term Loans. During the
Second Draw Period, subject to the terms and conditions of this Agreement, the Lenders agree that they shall make one or more term loans (each, a “Second Term Loan,” and, collectively, the “Second Term Loans,” and,
together with the First Term Loans, the “Term Loans”), available to Borrower in such amounts and with such allocations as may be requested by Borrowers by delivery of a Payment/Advance Form with respect to each requested Second Term
Loan to the Administrative Agent in accordance with Section 3.3; provided that (i) the aggregate principal amount of all Second Term Loans made hereunder shall not exceed Five Million Dollars ($5,000,000), and (ii) all Second
Term Loans made hereunder shall be made on the same Funding Date. Once repaid, a Term Loan may not be reborrowed. 
 (b) Pro
Rata Shares. All Term Loans shall be made by Lenders simultaneously and proportionately to their respective Pro Rata Shares, it being understood that no Lender shall be responsible for any default by any other Lender in such other Lender’s
obligation to make a Term Loan requested hereunder or purchase a participation required hereby nor shall any Term Commitment of any Lender be increased or decreased as a result of a default by any other Lender in such other Lender’s obligation
to make a Term Loan requested hereunder or purchase a participation required hereby. 
 (c) Interest Rate. The principal
amount outstanding under each Term Loan shall accrue interest at a fixed per annum rate equal to twelve and nine-tenths percent (12.90%) (the “Applicable Rate”). In computing interest, the date of the making of any Credit
Extension shall be included and the date of payment shall be excluded; provided, however, that if any Credit Extension is repaid on the same day on which it is made, such day shall be included in computing interest on such Credit Extension. Interest
shall be computed on the basis of a 360-day year for the actual number of days elapsed. 

 (d) Interest Payment Date. Unless otherwise provided, interest is payable monthly on
the Payment Date and is included in the Monthly Payment. 
 (e) Repayment. Each Term Loan, inclusive of interest thereon,
shall be repaid in 36 equal monthly installments, each installment to be in an amount equal to 3.33% of the original principal amount of the applicable Term Loan (with interest thereon compounding monthly) (each, a “Monthly Payment,”
and collectively, the “Monthly Payments”), each as reflected on Exhibit E attached hereto, commencing on the first Payment Date following the Funding Date for the applicable Term Loan. If a Borrower fails to pay any sum
to the Administrative Agent on its due date for payment, such Borrower shall pay to the Administrative Agent forthwith on demand interest on such sum (compounded on a monthly basis) from the due date to the date of actual payment at a rate equal to
the Applicable Rate plus five percent (5.0%) per annum. Payment or acceptance of the increased interest rate provided in this Section 2.2(e) is not a permitted alternative to timely payment and shall not constitute a waiver of any
Event of Default or otherwise prejudice or limit any rights or remedies of Administrative Agent. 
 (f) Interim Payment.
If the Funding Date for a Term Loan is not the first day of a calendar month, then on such Funding Date, the Borrower of such Term Loan shall pay to the Administrative Agent, for the ratable benefit of the Lenders, an interim loan repayment amount
equal to the product determined by multiplying (i) an amount equal to the quotient determined by dividing (A) the Monthly Payment by (B) thirty (30), and (ii) the number of days comprising the period commencing on such Funding
Date and ending on the first Payment Date for such Term Loan (such amount, an “Interim Payment”). 

(g) Payment Allocation. Each payment made with respect to any Term Loan shall be applied first to accrued and unpaid interest
thereon with the balance applied to principal. 
 (h) Ratable Sharing. Lenders hereby agree among themselves that if any
of them shall, whether by voluntary payment, through the exercise of any right of set off or banker’s Lien, by counterclaim or cross action or by the enforcement of any right under this Agreement or otherwise, or as adequate protection of a
deposit treated as cash collateral under the Bankruptcy Code, receive payment or reduction of a proportion of the aggregate amount of principal, interest, fees and other amounts then due and owing to such Lender hereunder or under the other Loan
Documents (collectively, the “Aggregate Amounts Due” to such Lender) which is greater than the proportion received by any other Lender in respect of the Aggregate Amounts Due to such other Lender, then the Lender receiving such
proportionately greater payment shall (a) notify the Administrative Agent and each other Lender of the receipt of such payment and (b) apply a portion of such payment to purchase participations (which it shall be deemed to have purchased
from each seller of a participation simultaneously upon the receipt by such seller of its portion of such payment) in the Aggregate Amounts Due to the other Lenders so that all such recoveries of Aggregate Amounts Due shall be shared by all Lenders
in proportion to the Aggregate Amounts Due to them; provided, if all or part of such proportionately greater payment received by such purchasing Lender is thereafter recovered from such Lender upon the bankruptcy or reorganization of a Credit Party
or otherwise, those purchases shall be rescinded and the purchase prices paid for such participations shall be returned to such purchasing Lender ratably to the extent of such recovery, but without interest. Borrowers expressly consent to the
foregoing arrangement and agree that any holder of a participation so purchased may exercise any and all rights of banker’s lien, set off or counterclaim with respect to any and all monies owing by Borrowers to that holder with respect thereto
as fully as if that holder were owed the amount of the participation held by that holder. 
 (i) Advance Payment. On the
Funding Date for each Term Loan, Borrowers shall pay to Lenders (by way of deduction by Lenders from the amount of such Term Loan advanced to a Borrower by Lenders on such Funding Date) an amount equal to the last Monthly Payment in respect of such
Term Loan advanced (the “Advance Payment”). Lenders shall hold the Advance Payment for application to the last Monthly Payment payable in respect of the related Term Loan. Borrowers shall not be entitled to any interest in respect
of any Advance Payment, nor shall any Advance Payment be subject to any set-off or other claim on the part of Borrowers. 

2.3. Fees. In addition to the fees or other payments due under the Term Loans, Borrowers shall pay to the Administrative Agent,
for the ratable benefit of the Lenders: 
 (a) Commitment Fee. A fully earned, non refundable commitment fee equal to One
Hundred and Twenty Thousand Dollars ($120,000), due on the initial Funding Date (the “Commitment Fee”); 
  

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 (b) Loan End Payment. A payment (the “Loan End Payment”) (in
addition to and not a substitution for the regular Monthly Payments) equal to one percent (1.00%) of the aggregate principal amount of the Term Loans advanced hereunder due on the earliest of (i) the date on which the Term Loans are
prepaid in full, (ii) the date on which the Term Loans are accelerated in accordance with Section 10 hereof, or (iii) the final Payment Date for the Term Loans; and 

(c) Lender Expenses. All Lender Expenses incurred through and after the Effective Date, when due. 

2.4. General Provisions Regarding Payments. 

(a) All payments (including prepayments) made on account of the Obligations shall be made (i) without condition or deduction for any
setoff, counterclaim, recoupment, or defense, in lawful money of the United States of America in immediately available same day funds, free and clear of and, subject to Section 2.7, without deduction for any Taxes, fees or other charges of any
nature whatsoever imposed by any Governmental Authority (other than a Tax on the overall net income of any Lender) (and in the event any such deduction is required to be made by applicable law from any such payment, such payment shall be grossed-up
so that the affected Lender receives the same amount (on an after-Tax basis) that such Lender would have received if such deduction had not been required), (ii) before 12:00 p.m. Eastern time on the date when due; and (iii) to the
Administrative Agent for distribution to the Lenders in accordance with their Pro Rata Shares. For purposes of computing interest and fees, funds received by the Administrative Agent after 12:00 p.m. Eastern time on the date when due shall be deemed
to have been paid by Borrower making such payment on the next succeeding Business Day. When a payment is due on a day that is not a Business Day, the payment shall be due the next Business Day, and additional fees or interest, as applicable, shall
continue to accrue until paid. 
 (b) The Administrative Agent (or its agent or sub-agent appointed by it) shall promptly
distribute to each Lender at such address as such Lender shall indicate in writing, such Lender’s applicable Pro Rata Share of all payments and prepayments of principal and interest due hereunder, together with all other amounts due thereto,
including all fees payable with respect thereto, to the extent received by Administrative Agent. 
 (c) Each Borrower hereby
authorizes the Administrative Agent to cause the Lenders to charge such Borrower’s accounts with any such Lender in order to cause timely payment to be made to Administrative Agent of all principal, interest, fees and expenses due hereunder
(subject to sufficient funds being available in its accounts for that purpose). 
 2.5. Prepayment. Borrowers shall be
entitled to prepay the amount of all outstanding Term Loans in whole (but not in part) at any time, and cancel any remaining unfunded commitment of the Lenders to make the Second Term Loans, subject to the following conditions: 

(a) Borrowers shall submit to the Administrative Agent an irrevocable written request to prepay all outstanding Term Loans and cancel any
such commitment at least fifteen (15) Business Days in advance indicating the aggregate amount to be paid, the amounts of such prepayment to be allocated to each outstanding Term Loan and the date of prepayment; and 

(b) the prepayment sum for all outstanding Term Loans shall be equal to the aggregate sum of all Monthly Payments of principal and
accrued interest thereon (as set forth in Sections 2.2(d) and 2.2(e) above), which would but for the prepayment have been paid in respect of such Term Loans throughout the remainder of the repayment term, discounted to present value at the
annual rate of three percent (3.0%) per annum. For the avoidance of doubt, the Loan End Payment is due and payable without discount in accordance with Section 2.3(b). 

2.6. Requirements of Law; Increased Costs. In the event that any applicable law, order, regulation, treaty or directive issued or
amended after the Effective Date by any applicable central bank or other Governmental Authority, or any change after the Effective Date in the governmental or judicial interpretation or application thereof, or compliance by any Lender with any
request or directive (whether or not having the force of law) issued subsequent to the date hereof by any central bank or other Governmental Authority: 
  

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 (a) Does or shall subject any Lender to any Tax of any kind whatsoever with respect to this
Agreement or any Term Loans made hereunder, or change the basis of taxation of payments to such Lender of principal, fee, interest or any other amount payable hereunder (except, in each case, for a change in the Tax on the overall net income of, or
franchise Taxes payable by, such Lender); 
 (b) Does or shall impose, modify or hold applicable any reserve, capital
requirement, special deposit, compulsory loan or similar requirements against assets held by, or deposits or other liabilities in or for the account of, advances or loans by, or other credit extended by, or any other acquisition of funds by, any
applicable lending office of any Lender making Loans hereunder; or 
 (c) Does or shall impose on such Lender any other
condition; and the result of any of the foregoing is to increase the cost to such Lender (as determined by such Lender in good faith using calculation methods customary in the industry) of making, renewing or maintaining any Loan or to reduce any
amount receivable in respect thereof or to reduce the rate of return on the capital of such Lender or any Person controlling such Lender, then, in any such case, Borrowers shall promptly pay to the Administrative Agent for remittance to such Lender,
upon its receipt of the certificate described below, any additional amounts necessary to compensate such Lender for such additional cost or reduced amounts receivable or rate of return as reasonably determined by such Lender with respect to this
Agreement or the Loans made hereunder. If a Lender becomes entitled to claim any additional amounts pursuant to this Section 2.6, it shall promptly notify Borrowers through the Administrative Agent of the event by reason of which it has
become so entitled, and a certificate as to any additional amounts payable pursuant to the foregoing sentence containing the calculation thereof in reasonable detail submitted by a Lender, through the Administrative Agent, to Borrowers shall be
conclusive in the absence of manifest error. The provisions hereof shall survive the termination of this Agreement and payment of the outstanding Term Loans and all other Obligations. 

Failure or delay on the part of any Lender to demand compensation for any increased costs or reduction in amounts received or receivable or reduction in
return on capital shall not constitute a waiver of such Lender’s right to demand such compensation; provided that Borrowers shall not be under any obligation to compensate any Lender under this Section 2.6 with respect to increased
costs or reductions with respect to any period prior to the date that is 180 days prior to the date of the delivery of the statement required pursuant to the foregoing paragraph; provided further that the foregoing limitation shall not apply to any
increased costs or reductions arising out of the retroactive application of any change in any law, treaty, governmental rule, regulation or order within such 180-day period. 

2.7. Taxes; Withholding, etc. 

(a) Payments to Be Free and Clear. All sums payable by any Credit Party hereunder and under the other Loan Documents shall (except
to the extent required by law) be paid free and clear of, and without any deduction or withholding on account of, any Tax (other than a Tax on the overall net income of any Lender) imposed, levied, collected, withheld or assessed by or within the
United States of America or any political subdivision in or of the United States of America or any other jurisdiction from or to which a payment is made by or on behalf of any Credit Party or by any federation or organization of which the United
States of America or any such jurisdiction is a member at the time of payment. In addition, Borrowers agree to pay, and shall indemnify and hold each Lender harmless from, any present or future stamp or documentary Taxes or any other sales,
transfer, excise, mortgage recording or property Taxes, charges or similar levies that arise from any payment made hereunder or under the Term Loans or from the execution, issuance, delivery or registration of, any of the Loan Documents, and within
thirty days after the date of paying such sum, the Borrowers shall furnish to the Lender the original or a certified copy of a receipt evidencing payment thereof. If a Lender or the Administrative Agent shall become aware that it is entitled to
receive a refund in respect of amounts paid by any Credit Party pursuant to this Section 2.7, which refund in the good faith judgment of such Lender or the Administrative Agent is allocable to such payment, it shall promptly notify such
Credit Party of the availability of such refund and shall, within 30 days after the receipt of a request by such Credit Party, apply for such refund. If any Lender or the Administrative Agent receives a refund in respect of any amounts paid by any
Credit Party pursuant to this Section 2.7 or any Lender receives a credit against the Tax on the overall net income of the Lender, which refund or credit in the good faith judgment of such Lender or the Administrative Agent is allocable
to such payment, it shall promptly notify such Credit Party of such refund or credit and shall, within 30 days after receipt, repay such refund or credit to such Credit Party net of all out-of-pocket expenses of such Lender or the Administrative
Agent; provided, however, that such Credit Party, upon the request of such Lender or the Administrative Agent, agrees to repay the amount paid over to such Credit Party to 

 

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such Lender or the Administrative Agent in the event such Lender or the Administrative Agent is required to repay such refund or credit. This Section 2.7(a) shall not apply with respect to a
Lender which was initially a Qualifying Lender but then ceases to be a Qualifying Lender. 
 (b) Withholding of Taxes. If
any Credit Party or any other Person is required by law to make any deduction or withholding on account of any such Tax from any sum paid or payable by any Credit Party to the Administrative Agent or any Lender under any of the Loan Documents:
(i) Borrowers shall notify the Administrative Agent of any such requirement or any change in any such requirement as soon as any Borrower becomes aware of it; (ii) Borrowers shall pay any such Tax before the date on which penalties attach
thereto, such payment to be made (if the liability to pay is imposed on any Credit Party) for its own account or (if that liability is imposed on the Administrative Agent or such Lender, as the case may be) on behalf of and in the name of the
Administrative Agent or such Lender; (iii) the sum payable by such Credit Party in respect of which the relevant deduction, withholding or payment is required shall be increased to the extent necessary to ensure that, after the making of that
deduction, withholding or payment (including any deductions applicable to additional sums payable under this Section 2.7(b)), the Administrative Agent or such Lender, as the case may be, receives on the due date a net sum equal to what
it would have received had no such deduction, withholding or payment been required or made; and (iv) within thirty days after paying any sum from which it is required by law to make any deduction or withholding, and within thirty days after the
due date of payment of any Tax which it is required by clause (ii) above to pay, Borrowers shall deliver to the Administrative Agent evidence satisfactory to the other affected parties of such deduction, withholding or payment and of the
remittance thereof to the relevant taxing or other Governmental Authority; provided, no such additional amount shall be required to be paid to any Lender under clause (iii) above except to the extent that any change after the date hereof in any
such requirement for a deduction, withholding or payment as is mentioned therein shall result in an increase in the rate of such deduction, withholding or payment from that in effect at the date hereof, in respect of payments to such Lender. In the
event that all or any portion of this Agreement is assigned by a Lender, no such additional amount shall be required to be paid to any assignee under clause (iii) above except to the extent that, after the date of the Assignment Agreement, any
change in any such requirement for a deduction, withholding or payment shall result in an increase in the rate of such deduction, withholding or payment from that in effect on the date of the Assignment Agreement. The Borrowers shall indemnify for
the full amount of any deduction, withholding, or payment made pursuant to this Section 2.7(b) (including without limitation any Taxes imposed by any jurisdiction on amounts payable under this Section 2.7(b)) paid by each
Lender and any liability (including penalties, interest and expense) arising therefrom or with respect thereto. Any indemnification payment pursuant to this Section 2.7 shall be made within thirty days from written demand therefor. This
Section 2.7(b) shall not apply with respect to a Lender which was initially a Qualifying Lender but then ceases to be a Qualifying Lender. 

(c) Evidence of Exemption From U.S. Withholding Tax. Each Lender that is not a United States Person (as such term
is defined in Section 7701(a)(30) of the Internal Revenue Code) for U.S. federal income Tax purposes (a “Non U.S. Lender”) shall deliver to the Administrative Agent for transmission to Borrowers, on or prior to the Effective
Date, and at such other times as may be necessary in the determination of Borrowers or the Administrative Agent (each in the reasonable exercise of its discretion), two original copies of Internal Revenue Service Form W 8BEN or W 8ECI (or any
successor forms), properly completed and duly executed by such Lender, and such other documentation required under the Internal Revenue Code and reasonably requested by Borrowers to establish that such Lender is not subject to deduction or
withholding of United States federal income Tax with respect to any payments to such Lender of principal, interest, fees or other amounts payable under any of the Loan Documents. Each Lender that is a United States person (as such term is defined in
Section 7701(a)(30) of the Internal Revenue Code) for United States federal income Tax purposes (a “U.S. Lender”) shall deliver to the Administrative Agent and Borrowers on or prior to the Effective Date two original copies of
Internal Revenue Service Form W-9 (or any successor form), properly completed and duly executed by such Lender, certifying that such U.S. Lender is entitled to an exemption from United States backup withholding, or otherwise prove that it is
entitled to such an exemption. Each Lender required to deliver any forms, certificates or other evidence with respect to United States federal income Tax or backup withholding matters pursuant to this Section 2.7(c) hereby agrees, from
time to time after the initial delivery by such Lender of such forms, certificates or other evidence, whenever a lapse in time or change in circumstances renders such forms, certificates or other evidence obsolete or inaccurate in any material
respect, that such Lender shall promptly deliver to the Administrative Agent for transmission to Borrowers two new original copies of Internal Revenue Service Form W-8BEN or W-8ECI or W-9 (or any successor form), as the case may be, properly
completed and duly executed by such Lender, and such other documentation required under the Internal Revenue Code and reasonably requested by Borrowers to confirm or 

 

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establish that such Lender is not subject to deduction, backup withholding or withholding of United States federal income Tax with respect to payments to such Lender under the Loan Documents, or
notify the Administrative Agent and Borrowers of its inability to deliver any such forms, certificates or other evidence. Borrowers shall not be required to pay any additional amount to any Non U.S. Lender under Section 2.7(b)(iii) if
such Lender shall have failed (1) to deliver the forms, certificates or other evidence referred to in this Section 2.7(c), or (2) to notify the Administrative Agent and Borrowers of its inability to deliver any such
forms, certificates or other evidence, as the case may be; provided, if such Lender shall have satisfied the requirements of the first sentence of this Section 2.7(c) on the Effective Date, nothing in this last sentence of this
Section 2.7(c) shall relieve Borrowers of their obligations to pay any additional amounts pursuant to this Section 2.7 in the event that, as a result of any change in any applicable law, treaty or governmental rule,
regulation or order, or any change in the interpretation, administration or application thereof, such Lender is no longer properly entitled to deliver forms, certificates or other evidence at a subsequent date establishing the fact that such Lender
is not subject to withholding as described herein. 
 2.8. Defaulting Lenders. Anything contained herein to the contrary
notwithstanding, in the event that any Lender, other than at the direction or request of any regulatory agency or authority, defaults (a “Defaulting Lender”) in its obligation to fund (a “Funding Default”)
any Term Loan (in each case, a “Defaulted Loan”), then (a) during any Default Period with respect to such Defaulting Lender, such Defaulting Lender shall be deemed not to be a “Lender” for purposes of
voting on any matters (including the granting of any consents or waivers) with respect to any of the Loan Documents; and (b) to the extent permitted by applicable law, until such time as the Defaulting Lender shall have cured such Funding
Default, (i) any voluntary prepayment of the Term Loans shall, if such paying Borrower so directs at the time of making such voluntary prepayment, be applied to the Term Loans of other Lenders as if such Defaulting Lender had no Term Loans
outstanding, and (ii) any mandatory prepayment of the Term Loans shall, if such paying Borrower so directs at the time of making such mandatory prepayment, be applied to the Term Loans of other Lenders (but not to the Term Loans of such
Defaulting Lender) as if such Defaulting Lender had funded all Defaulted Loans of such Defaulting Lender, it being understood and agreed that such paying Borrower shall be entitled to retain any portion of any mandatory prepayment of the Term Loans
that is not paid to such Defaulting Lender solely as a result of the operation of the provisions of this clause (b). No Term Commitment of any Lender shall be increased or otherwise affected, and, except as otherwise expressly provided in this
Section 2.8, performance by Borrowers of their obligations hereunder and the other Loan Documents shall not be excused or otherwise modified as a result of any Funding Default or the operation of this Section 2.8. The rights
and remedies against a Defaulting Lender under this Section 2.8 are in addition to other rights and remedies which Borrowers may have against such Defaulting Lender with respect to any Funding Default and which the Administrative Agent
or any Lender may have against such Defaulting Lender with respect to any Funding Default. 
 2.9. Evidence of Debt;
Register; Lenders’ Books and Records; Term Loan Notes. 
 (a) Lenders’ Evidence of Debt. Each Lender shall
maintain on its internal records an account or accounts evidencing the Obligations of each Borrower to such Lender, including the amounts of the Term Loans made by it and each repayment and prepayment in respect thereof. Any such recordation shall
be conclusive and binding on Borrowers, absent manifest error; provided, that the failure to make any such recordation, or any error in such recordation, shall not affect any Lender’s Term Commitments or Borrowers’ Obligations in respect
of any applicable Term Loans; and provided further, in the event of any inconsistency between the Register and any Lender’s records, the recordations in the Register shall govern, absent manifest error. 

(b) Register. Administrative Agent (or its agent or sub-agent appointed by it) shall maintain at its principal office (as
specified in, or as otherwise identified upon notice to the other parties hereto in accordance with, Section 12), a register for the recordation of the names and addresses of Lenders, the Term Commitments, and related principal of, and
interest on, the Term Loans of each from time to time (the “Register”). The Register shall be available for inspection by Borrowers, any Lender (with respect to any entry relating to such Lender’s Term Loans) at any
reasonable time and from time to time upon reasonable prior notice. Administrative Agent shall record, or shall cause to be recorded, in the Register the Term Commitments and the related principal of, and interest on, the Term Loans of each Lender
in accordance with the provisions of Section 14.1, and each repayment or prepayment in respect of the principal amount of the Term Loans and any such recordation shall be conclusive and binding on Borrowers and each Lender, absent
manifest error; provided, failure to make any such recordation, or any error in such recordation, shall not affect any Lender’s Term Commitments or Borrowers’ Obligations in respect of any Term Loan. Borrowers hereby designate
Administrative Agent to serve as Borrowers’ agent solely for purposes of maintaining the Register as provided in this Section 2.9, and Borrowers hereby agree that, to the extent

  

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Administrative Agent serves in such capacity, Administrative Agent and its officers, directors, employees, agents, sub-agents and affiliates shall constitute “Indemnitees.”

 (c) Term Loan Notes. If so requested by any Lender by written notice to Borrowers (with a copy to Administrative
Agent) at least two Business Days prior to the Funding Date of any Term Loan, or at any time thereafter, Borrower with respect to such Term Loan shall execute and deliver to such Lender (and/or, if applicable and if so specified in such notice, to
any Person who is an assignee of such Lender pursuant to Section 14.1) on such Funding Date (or, if such notice is delivered after such Funding Date, promptly after Borrower’s receipt of such notice) a Term Loan Note to evidence
such Lender’s Term Loan. 
 3. CONDITIONS OF LOANS 

3.1. Conditions Precedent to Initial Credit Extension. The Lenders’ obligations to make the initial Credit
Extension is subject to the condition precedent that the Administrative Agent shall have received, in form and substance satisfactory to the Administrative Agent, such documents, and completion of such other matters, as the Administrative Agent may
reasonably deem necessary or appropriate, including, without
limitation: 

(a) copies of the Loan Documents originally executed and delivered by each applicable Credit Party, and each schedule to such Loan
Documents (such schedules to be in form and substance reasonably satisfactory to the Administrative Agent); 
 (b) Operating
Documents of each of the Credit Parties; 
 (c) the organizational structure and capital structure of each of the Credit Parties
shall be as set forth on Schedule 3.1(c); 
 (d) (i) a good standing certificate of Guarantor and Horizon, in each case,
certified by the Secretary of State of the State of Delaware as of a date no earlier than thirty (30) days prior to the Effective Date, (ii) a good standing certificate or foreign equivalent of Nitec, certified by the Registrar of Commerce
as of a date no earlier than thirty (30) days prior to the Effective Date, and (iii) a list of all pending debt collection proceedings against Nitec issued by the competent debt collection authorities (Betreibungsamt) as of the Effective
Date; 
 (e) Secretary’s Certificate with completed Borrowing Resolutions for each Credit Party; 

(f) certified copies, dated as of a recent date, of financing statement searches, as the Administrative Agent shall request, accompanied
by written evidence (including any UCC termination statements) that the Liens indicated in any such financing statements either constitute Permitted Liens or have been or, in connection with the initial Credit Extension, will be terminated or
released; 
 (g) each Credit Party shall have obtained all Governmental Approvals and all consents of other Persons, in each
case that are necessary or advisable in connection with the transactions contemplated by the Loan Documents and each of the foregoing shall be in full force and effect and in form and substance reasonably satisfactory to the Administrative Agent.
All applicable waiting periods shall have expired without any action being taken or threatened by any competent authority which would restrain, prevent or otherwise impose adverse conditions on the transactions contemplated by the Loan Documents or
the financing thereof and no action, request for stay, petition for review or rehearing, reconsideration, or appeal with respect to any of the foregoing shall be pending, and the time for any applicable agency to take action to set aside its consent
on its own motion shall have expired; 
 (h) if requested by the Administrative Agent, a landlord’s consent in favor of the
Administrative Agent for each Credit Party’s leased locations by the respective landlord thereof (which consent shall include an agreement by such landlord to permit reasonable access to such leased premises by the Administrative Agent or its
agents upon an Event of Default for purposes of removal of any and all Collateral, if such leased premises is a warehouse, distribution center or other location at which a material amount of Collateral is located), together with the duly executed
original signatures thereto; 
  

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 (i) opinions of counsel (which counsel shall be reasonably satisfactory to the
Administrative Agent) with respect to the creation and perfection of the security interests in favor of the Administrative Agent in such Collateral and such other matters governed by the laws of each jurisdiction in which any Credit Party or any
personal property Collateral is located as the Administrative Agent may reasonably request, in each case in form and substance reasonably satisfactory to Administrative Agent; 

(j) a copy of any registration rights agreement, investors’ rights agreement or other similar agreement relating to, governing or
otherwise affecting the ownership of the capital stock or other equity ownership interests of any Credit Party, and any amendments thereto; 

(k) evidence that the insurance policies required by Section 6.5 hereof are in full force and effect, together with
appropriate evidence showing loss payable and/or additional insured clauses or endorsements in favor of the Administrative Agent, for the ratable benefit of the Lenders; 

(l) evidence that each Credit Party shall have taken or caused to be taken any other action, executed and delivered or caused to be
executed and delivered any other agreement, document and instrument and made or caused to be made any other filing and recording (other than as set forth herein) reasonably required by the Administrative Agent; 

(m) all documentation and other information required by bank regulatory authorities under applicable “know-your-customer” and
anti-money laundering rules and regulations, including the U.S.A. Patriot Act (Title III of Pub. L. 107-56 (signed into law October 26, 2001)) (the “Patriot Act”); 

(n) all documentation and other information relating to the acquisition of Nitec by Guarantor and written certification by a Responsible
Officer of each Borrower that such transaction, has been, or contemporaneously with the making of the First Term Loan will be, consummated; 

(o) all documentation and other information relating to the Series B Preferred Stock and convertible note financing of the Guarantor and
written certification by a Responsible Officer of Guarantor that such transaction, has been, or contemporaneously with the making of the First Term Loan, will be consummated, and that the proceeds of such financing received by Guarantor were or will
be at least $20,000,000; provided that no more than $1,385,714.88 may be received not more than ten (10) Business Days after the Effective Date; 

(p) evidence that all steps necessary to properly perfect the security interest granted by Nitec pursuant to Section 8 of
this Agreement with respect to Collateral of Nitec located outside the United States have been, or contemporaneously with the making of the First Term Loan will be, taken; 

(q) copies of the Warrants originally executed and delivered by the Guarantor; 

(r) copies of the Nitec Debt Guaranty originally executed and delivered by each of Guarantor and Horizon; 

(s) Ratification by the sole shareholder of Nitec of this Agreement and that certain Securities Pledge Agreement in respect of
intellectual property rights, receivables, bank accounts and certain other claims between Nitec and the Administrative Agent, dated as of the date hereof, such ratification to be effective immediately following the closing of the transactions
pursuant to which the Borrowers become wholly owned subsidiaries of the Guarantor; and 
 (t) payment of the fees and Lender
Expenses then due as specified in Section 2.3 hereof. 
 3.2. Conditions Precedent to Making of Second Term
Loans. The Lenders’ obligations to make the Second Term Loans is subject to the condition precedent that the Administrative Agent shall have received an Officer’s Certificate executed by a Responsible Officer certifying that a
Financing Event has occurred. 
 3.3. Conditions Precedent to all Credit Extensions. Lenders’ obligations to make
each Credit Extension, including the initial Credit Extension and the Second Term Loans, is subject to the following conditions precedent: 
  

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 (a) except as otherwise provided in Section 3.5, timely receipt of one or more
executed Payment/Advance Forms; 
 (b) the representations and warranties of the Credit Parties in this Agreement shall be true,
accurate, and complete in all material respects on the date of the Payment/Advance Form and on the Funding Date of each Credit Extension; provided, however, that such materiality qualifier shall not be applicable to any representations and
warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material
respects as of such date, and no Event of Default shall have occurred and be continuing or result from the Credit Extension. Each Credit Extension is the Credit Parties’ representation and warranty on that date that the representations and
warranties of the Credit Parties in this Agreement remain true, accurate, and complete in all material respects; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are
qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date;

 (c) in the Administrative Agent’s sole discretion, there has not been any material impairment in the general affairs,
management, results of operation, financial condition or the prospect of repayment of the Obligations, or any material adverse deviation by the Credit Parties from the most recent business plan of the Credit Parties presented to and accepted by the
Administrative Agent; and 
 (d) as of the date of such Credit Extension, no event shall have occurred and be continuing or
would result from the consummation of the applicable Credit Extension that would constitute an Event of Default hereunder. 

3.4. Covenant to Deliver. The Credit Parties agree to deliver to the Administrative Agent each item required to be delivered to
the Administrative Agent under this Agreement as a condition precedent to any Credit Extension. The Credit Parties expressly agree that a Credit Extension made prior to the receipt by the Administrative Agent of any such item shall not constitute a
waiver by the Administrative Agent of the Credit Parties’ obligation to deliver such item, and the making of any Credit Extension in the absence of a required item shall be in the Administrative Agent’s sole discretion. 

3.5. Procedures for Borrowing. Subject to the prior satisfaction of all other applicable conditions to the making of a Term Loan
set forth in this Agreement, to obtain a Term Loan, Borrowers shall notify the Administrative Agent (which notice shall be irrevocable on and after the date on which such notice is given and Borrowers shall be bound to make a borrowing in accordance
therewith) by electronic mail, facsimile, or telephone by 12:00 noon Eastern time no less than fifteen (15) Business Days prior to the date the Term Loan is to be made; provided that Borrowers shall not be required to give advance notice to the
Administrative Agent with respect to the First Term Loan. Together with any such electronic or facsimile notification, Borrowers shall deliver to the Administrative Agent by electronic mail or facsimile a completed Payment/Advance Form for each
requested Term Loan executed by a Responsible Officer of each applicable Borrower, or his or her designee. The Administrative Agent may rely on any telephone notice given by a person who the Administrative Agent believes is a Responsible Officer or
designee. Each Lender shall make the amount of its Pro Rata Share of each Term Loan available to Administrative Agent not later than 12:00 p.m. (Eastern time) on the applicable Funding Date by wire transfer of same day funds in Dollars, at the
Principal Office designated by the Administrative Agent. Except as provided herein, upon satisfaction or waiver of the conditions precedent to the making of Term Loans specified herein, the Administrative Agent shall make the proceeds of such Term
Loans available to the requesting Borrower(s) on the applicable Funding Date by causing an amount of same day funds in Dollars equal to the proceeds of all such Term Loans received by Administrative Agent from Lenders to be made available to the
requesting Borrower(s) by wire transfer of immediately available funds in Dollars to such account as may be designated in writing to the Administrative Agent by the requesting Borrower(s). 

4. CREATION OF SECURITY INTEREST 

4.1. Grant of Security Interest. Each of the Credit Parties hereby grants the Administrative Agent, for the ratable benefit of the
Lenders, to secure the payment and performance in full of all of the Obligations, a continuing security interest in, and pledges to the Administrative Agent, for the ratable benefit of the Lenders, the

  

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Collateral, wherever located, whether now owned or hereafter acquired or arising, and all proceeds and products thereof. 

4.2. Priority of Security Interest. 

(a) Each Credit Party represents, warrants, and covenants that the security interest granted herein is and shall at all times continue to
be a first priority perfected security interest in the Collateral (subject only to Permitted Liens that may have superior priority to the Administrative Agent’s Lien under this Agreement). If a Credit Party shall acquire a commercial tort
claim, such Credit Party shall promptly notify the Administrative Agent in a writing signed by such Credit Party of the general details thereof and grant to the Administrative Agent, for the ratable benefit of the Lenders, in such writing a security
interest therein and in the proceeds thereof, all upon the terms of this Agreement, with such writing to be in form and substance reasonably satisfactory to the Administrative Agent. 

(b) Notwithstanding anything herein to the contrary, upon the receipt by the Administrative Agent of an Officer’s Certificate
certifying that Guarantor has completed a Qualified IPO, the security interest granted hereby by the Credit Parties with respect to the Intellectual Property Collateral shall automatically terminate, and the Administrative Agent shall promptly
thereafter, at the sole cost and expense of the Credit Parties, execute and deliver to the Credit Parties all such documents and instruments as shall be necessary to evidence termination of such security interest; provided that, if a judicial
authority (including a U.S. Bankruptcy Court) would hold that a security interest in the underlying Intellectual Property Collateral is necessary to have a security interest in the IP Collateral Proceeds, then the Collateral shall automatically, and
effective as of the Effective Date, include the Intellectual Property Collateral to the extent necessary to permit perfection of the Administrative Agent’s security interest in such IP Collateral Proceeds. 

(c) If at any time on or after December 31, 2012, the Nitec Release Event occurs, and provided that no Event of Default shall have
occurred and be continuing, the Credit Parties may, by written notice to the Administrative Agent, request (i) that Nitec be released as a Credit Party hereunder, (ii) that the Lien in favor of the Administrative Agent in respect of the
Nitec Collateral be terminated, and (iii) that the Lien in favor of the Administrative Agent in respect of the capital stock of Nitec held by the Guarantor be limited to not more than 65% of the total combined voting power of all classes of
stock entitled to vote the shares of capital stock of Nitec. The Administrative Agent shall promptly notify Lenders of its receipt of any such request and, upon the written consent of the Lenders, which consent shall not be unreasonably withheld,
the Administrative Agent and the Lenders shall promptly thereafter, at the sole cost and expense of the Credit Parties, take all steps necessary to cause (i) Nitec to be released as a Credit Party hereunder, (ii) the Administrative
Agent’s Lien in respect of the Nitec Collateral to be terminated, and (iii) the Lien in favor of the Administrative Agent in respect of the capital stock of Nitec held by the Guarantor to be limited to not more than 65% of the total
combined voting power of all classes of stock entitled to vote the shares of capital stock of Nitec; provided, that, concurrently therewith, (W) Nitec shall enter into an amended loan and security agreement with the Administrative Agent and the
Lenders on substantially the same terms provided herein except that the Lien granted by Nitec thereunder in favor of the Administrative Agent shall not secure any of the Term Loans made to Horizon hereunder or any of the other Obligations of
Guarantor or Horizon (the “New Nitec Loan Agreement”), (X) each of Guarantor and Horizon shall become a guarantor of, and shall pledge all of its assets (or if Guarantor has completed a Qualified IPO, all of the assets of
Guarantor and Horizon except the Intellectual Property Collateral) to secure the satisfaction of, all obligations of Nitec arising under the New. Nitec Loan Agreement; (Y) the New Nitec Loan Agreement shall contain customary cross-default
provisions, such that a default under this Agreement shall be an Event of Default thereunder, and (Z) the Borrowers will treat each of the Term Loans and the New Nitec Loan Agreement as a continuation of the Term Loans as to which no gain or
loss is realized for U.S. federal income Tax purposes. The date on which each of the actions described in the immediately preceding sentence occurs is called the “Nitec Release Event Completion Date.” 

(d) If this Agreement is terminated, the Administrative Agent’s Lien in the Collateral shall continue until the Obligations (other
than inchoate indemnity obligations) are repaid in full in cash. Upon payment in full in cash of the Obligations (other than inchoate indemnity obligations) and at such time as the Lenders’ obligations to make Credit Extensions has terminated,
the Administrative Agent shall, at the Credit Parties’ sole cost and expense, release its Liens in the Collateral and all rights therein shall revert to the appropriate Credit Parties. 

 

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 4.3. Authorization to File Financing Statements. The Credit Parties hereby authorize
the Administrative Agent to file financing statements, without notice to the Credit Parties, with all appropriate jurisdictions to perfect or protect the Administrative Agent’s interest or rights hereunder, including a notice that any
disposition of the Collateral, by either the Credit Parties or any other Person, shall be deemed to violate the rights of the Administrative Agent under the Code, except dispositions permitted hereunder. Such financing statements may indicate the
Collateral as “all assets of the Debtor” or words of similar effect, or as being of an equal or lesser scope, or with greater detail, all in the Administrative Agent’s discretion. 

5. REPRESENTATIONS AND WARRANTIES 

In order to induce Lenders and the Administrative Agent to enter into this Agreement and to make each Credit Extension to be made thereby,
each Credit Party, jointly and severally, represents and warrants to each Lender and the Administrative Agent that the following statements are true and correct: 

5.1. Due Organization, Authorization; Power and Authority. Each Credit Party (a) is duly organized, validly existing and in
good standing under the laws of its jurisdiction of organization as identified in Schedule 5.1, (b) has all requisite power and authority to own and operate its properties, to carry on its business as now conducted and as proposed to be
conducted, to enter into the Loan Documents to which it is a party and to carry out the transactions contemplated thereby, and (c) is qualified to do business and in good standing in every jurisdiction where its assets are located and wherever
necessary to carry out its business and operations except where the failure to do so could not reasonably be expected to have a material adverse effect on its business. 

5.2. Equity Interests and Ownership. The Equity Interests of each Credit Party have been duly authorized and validly issued and
are fully paid and non assessable. Except as set forth on Schedule 5.2, as of the date hereof, there is no existing option, warrant, call, right, commitment or other agreement to which any Credit Party is a party requiring, and there is no
membership interest or other Equity Interests of any Credit Party outstanding which upon conversion or exchange would require, the issuance by any Credit Party of any additional membership interests or other Equity Interests of any Credit Party or
other Equity Interests convertible into, exchangeable for or evidencing the right to subscribe for or purchase, a membership interest or other Equity Interests of any Credit Party. Schedule 5.2 correctly sets forth the ownership interest of
each Credit Party in its respective Subsidiaries as of the Effective Date. The organizational structure and capital structure of each of the Credit Parties is as set forth on Schedule 3.1(c). 

5.3. No Conflict; Government Consents. The execution, delivery and performance by each Credit Party of the Loan Documents to which
it is a party do not (i) conflict with any of such Credit Party’s Operating Documents, (ii) contravene, conflict with, constitute a default under or violate any material Requirement of Law, (iii) contravene, conflict or violate
any applicable order, writ, judgment, injunction, decree, determination or award of any Governmental Authority by which such Credit Party or any of its Subsidiaries or any of their property or assets may be bound or affected, (iv) require any
action by, filing, registration, or qualification with, or Governmental Approval from, any Governmental Authority (except (x) such Governmental Approvals which have already been obtained and are in full force and effect, (y) for filings
and recordings with respect to the Collateral to be made, or otherwise delivered to the Administrative Agent for filing and/or recordation on or after the Effective Date and (z) any registration, consent, approval, notice or action to the
extent that the failure to undertake or obtain such registration, consent, approval, notice or action could not reasonably be expected to result in a Material Adverse Change), (v) constitute an event of default under any material agreement by
which such Credit Party is bound or (vi) require any approval of stockholders, members or partners or any approval or consent of any Person except for such approvals or consents which will be obtained on of before the Effective Date and
disclosed in writing to the Administrative Agent and except for any such approvals or consents the failure of which to obtain will not result in a Material Adverse Change. No Credit Party is in default under any agreement to which it is a party or
by which it is bound in which the default could reasonably be expected to have a material adverse effect on such Credit Party’s business. 

5.4. Binding Obligation. Each Loan Document has been duly executed and delivered by each Credit Party that is a party thereto and
is the legally valid and binding obligation of such Credit Party, enforceable against such Credit Party in accordance with its respective terms, except as may be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws relating
to or limiting creditors’ rights generally or by equitable principles relating to enforceability. 
  

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 5.5. Collateral. In connection with this Agreement, each Credit Party has delivered
to the Administrative Agent a completed certificate signed by such Credit Party, (each, a “Perfection Certificate, and collectively, the “Perfection Certificates”). Each Credit Party represents and warrants to the
Administrative Agent that: 
 (a) (i) its exact legal name is that indicated on its Perfection Certificate and on the signature
page hereof; (ii) it is an organization of the type and is organized in the jurisdiction set forth in its Perfection Certificate; (iii) its Perfection Certificate accurately sets forth its organizational identification number or accurately
states that it has none; (iv) its Perfection Certificate accurately sets forth its place of business, or, if more than one, its chief executive office as well as its mailing address (if different than its chief executive office); (v) it
(and each of its predecessors) has not, in the past five (5) years, changed its jurisdiction of formation, organizational structure or type, or any organizational number assigned by its jurisdiction; and (vi) all other information set
forth on its Perfection Certificate pertaining to it and each of its Subsidiaries is accurate and complete (it being understood and agreed that each Credit Party may from time to time update certain information in its Perfection Certificate after
the Effective Date to the extent permitted by one or more specific provisions in this Agreement). If any Credit Party is not now a Registered Organization but later becomes one, it shall promptly notify the Administrative Agent of such occurrence
and provide the Administrative Agent with such Credit Party’s organizational identification number. The Administrative Agent and the Lenders hereby agree that the Perfection Certificate shall be deemed to be updated to reflect information
provided in any notice delivered by any Credit Party to the Administrative Agent pursuant to the last full paragraph of Section 7.2 below; provided that any update to the Perfection Certificate by any Credit Party pursuant to the last
full paragraph of Section 7.2 below shall not relieve any Credit Party of any other Obligation under this Agreement, including (without limitation) its Obligations pursuant to Section 6.7(b). 

(b) (i) it has good title to, has rights in, and the power to transfer each item of the Collateral upon which it purports to grant a Lien
hereunder, free and clear of any and all Liens except Permitted Liens, (ii) it has no deposit accounts other than the deposit accounts with Silicon Valley Bank, the deposit accounts, if any, described in the Perfection Certificate delivered to
the Administrative Agent in connection herewith, or of which such Credit Party has given the Administrative Agent notice and taken such actions as are necessary to give Administrative Agent a perfected security interest therein (and upon delivery of
such notice and taking such action, the Perfection Certificate will be deemed to be updated with the information contained in such notice), (iii) Collateral is not in the possession of any third party bailee (such as a warehouse) except as
otherwise provided in the Perfection Certificate or as permitted pursuant to Section 7.2. None of the components of the Collateral shall be maintained at locations other than as provided in the Perfection Certificate or as permitted
pursuant to Section 7.2. 
 (c) All Inventory is in all material respects of good and marketable quality, free from
material defects. 
 (d) It is the sole owner of the Intellectual Property which it owns or purports to own except for
(a) Permitted Licenses, (b) over-the-counter software that is commercially available to the public, and (c) material Intellectual Property licensed to it and noted on the Perfection Certificate (as the same may be updated from time to
time). Each Patent which it owns or purports to own and which is material to its business is valid and enforceable, and no part of the Intellectual Property which it owns or purports to own and which is material to it business has been judged
invalid or unenforceable, in whole or in part. To the best of its knowledge, no claim has been made that any part of its Intellectual Property violates the rights of any third party except to the extent such claim would not reasonably be expected to
have a material adverse effect on its business. 
 (e) Except as noted on its Perfection Certificate (as the same may be updated
from time to time), it is not a party to, nor is it bound by, any Restricted License. 
 (f) With respect to any Subsidiary that
is not a Credit Party hereunder, the assets of such Subsidiary do not exceed One Million Dollars ($1,000,000), in the aggregate. 

5.6. Adverse Proceedings, etc. There are no Adverse Proceedings, individually or in the aggregate, that could reasonably be
expected to result in a Material Adverse Change. No Credit Party (a) is in violation of any applicable laws (including Environmental Laws) that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse
Change, or (b) is subject to or in default with respect to any final judgments, orders, 
  

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writs, injunctions, decrees, rules or regulations of any court or any federal, state, municipal or other governmental department, commission, board, bureau, agency or instrumentality, domestic or
foreign, that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse Change. 
 5.7.
Financial Statements; Financial Condition. All consolidated financial statements for any Credit Party delivered to the Administrative Agent were prepared in conformity with Applicable Accounting Standards and fairly present in all material
respects such Credit Party’s consolidated financial condition and such Credit Party’s consolidated results of operations. There has not been any material deterioration in any Credit Party’s consolidated financial condition since the
date of the most recent financial statements submitted to the Administrative Agent. No Credit Party has any contingent liability or liability for Taxes, long term lease (other than long-term leases entered into in the ordinary course of business) or
unusual forward or long term commitment that is not reflected in the consolidated financial statements or the notes thereto and which in any such case is material in relation to the business, operations, properties, assets, or condition (financial
or otherwise) of any Credit Party taken as a whole. 
 5.8. Solvency. As of the Effective Date, after giving effect to
the transactions contemplated by this Agreement and the transaction pursuant to which the Borrowers became wholly owned Subsidiaries of Guarantor, the fair salable value of each Credit Party’s assets (including goodwill minus disposition costs)
exceeds the fair value of its liabilities; no Credit Party is left with unreasonably small capital after the transactions in this Agreement; Nitec is not “over-indebted” (within the meaning of the applicable laws of Switzerland and
Applicable Accounting Standards); and each Credit Party is able to pay its debts (including trade debts) as they mature. Without limiting the generality of the foregoing, as of the Effective Date, there has been no proposal made or resolution
adopted by any competent corporate body for the dissolution or liquidation of any Credit Party, nor do any circumstances exist which may result in the dissolution or liquidation of any Credit Party. As of the Effective Date, no proposal has been
made nor any resolution been adopted by any competent corporate body of any Credit Party for the statutory merger of such Credit Party with any other Person. As of the Effective Date, none of the Credit Parties has (i) made a general assignment
for the benefit of creditors, (ii) filed any voluntary petition in bankruptcy or suffered the filing of an involuntary petition by any creditor, (iii) suffered the appointment of a receiver to take possession of all or any portion of its
assets, (iv) suffered the attachment or judicial seizure of all or any portion of its assets, (v) admitted in writing its inability to pay its debts as they come due, nor (vi) made an offer of settlement, extension or composition to
its creditors generally. 
 5.9. Payment of Taxes. All federal, material state, material provincial and other material
Tax returns and reports (or extensions thereof) of each Credit Party and its Subsidiaries required to be filed by any of them have been timely filed, and all Taxes reflected therein which are due and payable and all assessments, fees and other
governmental charges upon any Credit Party and its Subsidiaries and upon their respective properties, assets, income, businesses and franchises which are due and payable have been paid when due and payable. No Credit Party knows of any proposed Tax
deficiency or assessment against it or any of its Subsidiaries which is not being actively contested by it or such Subsidiary in good faith and by appropriate proceedings; provided, such reserves or other appropriate provisions, if any, as shall be
required in conformity with Applicable Accounting Standards shall have been made or provided therefor. Each Credit Party has paid all amounts necessary to fund all present pension, profit sharing and deferred compensation plans in accordance with
their terms, and no Credit Party has withdrawn from participation in, and has not permitted partial or complete termination of, or permitted the occurrence of any other event with respect to, any such plan which could reasonably be expected to
result in any liability of such Credit Party, including any liability to the Pension Benefit Guaranty Corporation or its successors or any other Governmental Authority. Neither any Credit Party nor any of its Subsidiaries have executed or filed with
the Internal Revenue Service or any other Governmental Authority any agreement or other document extending, or having the effect of extending, the period for assessment or collection of any Taxes nor has there been any request in writing for such
extension. Neither any Credit Party nor any of its Subsidiaries has agreed or has been requested to make any adjustment under IRC Section 481(a) by reason of a change in accounting method or otherwise. Neither any Credit Party nor any of its
Subsidiaries has any obligation under any written tax sharing agreement. No Credit Party nor any Subsidiary has been a member of an affiliated group filing a consolidated U.S. federal income tax return within the meaning of the Internal Revenue Code
and has no liability for Taxes of any other Person under IRC Section 1.1502-6 (or similar provision of foreign, state, or local law) as a transferee or successor, by contract, or otherwise. No Credit Party nor any Subsidiary has distributed
stock of another Person, nor has had its stock distributed by another Person, in a transaction that was purported or intended to be governed in whole or in part by IRC Sections 355 or 361 during any year for which the statute of limitations does not
bar the assessment of U.S. 
  

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federal income tax. The Credit Parties structured the acquisition of Nitec and Horizon by Guarantor with the intent that no gain would be recognized on the acquisition for U.S. federal income tax
purposes. 
 5.10. Environmental Matters. No Credit Party nor any of its respective Facilities or operations are subject
to any outstanding written order, consent decree or settlement agreement with any Person relating to any Environmental Law, any Environmental Claim, or any Hazardous Materials Activity that, individually or in the aggregate, could reasonably be
expected to result in a Material Adverse Change. No Credit Party has received any letter or request for information under Section 104 of the Comprehensive Environmental Response, Compensation, and Liability Act (42 U.S.C. § 9604) or any
comparable state law. There are and, to each Credit Party’s knowledge, have been, no conditions, occurrences, or Hazardous Materials Activities which could reasonably be expected to form the basis of an Environmental Claim against any Credit
Party that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse Change. To any Credit Party’s knowledge, no predecessor of any Credit Party has filed any notice under any Environmental Law indicating
past or present treatment of Hazardous Materials at any Facility, and no Credit Party’s operations involves the generation, transportation, treatment, storage or disposal of hazardous waste, as defined under 40 C.F.R. Parts 260 270 or any state
equivalent. Compliance with all current or reasonably foreseeable future requirements pursuant to or under Environmental Laws could not be reasonably expected to result in, individually or in the aggregate, a Material Adverse Change. No event or
condition has occurred or is occurring with respect to any Credit Party relating to any Environmental Law, any Release of Hazardous Materials, or any Hazardous Materials Activity which individually or in the aggregate has resulted in, or could
reasonably be expected to result in, a Material Adverse Change. 
 5.11. Material Contracts. Schedule 5.11 contains a
true, correct and complete list of all the Material Contracts in effect on the Effective Date, and, after giving effect to consummation of the transactions contemplated by this Agreement, except as described thereon, all such Material Contracts are
in full force and effect and no defaults currently exist thereunder. 
 5.12. Regulatory Compliance. No Credit Party is
an “investment company” or a company “controlled” by an “investment company” under the Investment Company Act of 1940, as amended. No Credit Party is engaged as one of its important activities in extending credit for
margin stock (under Regulations X, T and U of the Federal Reserve Board). Each Credit Party has complied in all material respects with the Federal Fair Labor Standards Act. No Credit Party nor any of its Subsidiaries is a “holding company”
or an “affiliate” of a “holding company” or a “subsidiary company” of a “holding company” as each term is defined and used in the Public Utility Holding Company Act of 2005. No Credit Party has violated any
laws, ordinances or rules, the violation of which could reasonably be expected to have a material adverse effect on its business. 

5.13. Margin Stock. No Credit Party is engaged, nor will it engage, principally or as one of its important activities, in the
business of extending credit for the purpose of “purchasing” or “carrying” any “margin stock” as such terms are defined in Regulation U of the Federal Reserve Board as now and from time to time hereafter in effect (such
securities being referred to herein as (“Margin Stock”). No Credit Party owns any Margin Stock, and none of the proceeds of the Credit Extensions or other extensions of credit under this Agreement will be used, directly or
indirectly, for the purpose of purchasing or carrying any Margin Stock, for the purpose of reducing or retiring any Indebtedness that was originally incurred to purchase or carry any Margin Stock or for any other purpose that might cause any of the
Term Loans or other extensions of credit under this Agreement to be considered a “purpose credit” within the meaning of Regulations T, U or X of the Federal Reserve Board. No Credit Party or any of its Subsidiaries will take or permit to
be taken any action that might cause any Loan Document to violate any regulation of the Federal Reserve Board. 
 5.14.
Subsidiaries; Investments. No Credit Party owns any stock, partnership interest or other equity securities except for Permitted Investments. 

5.15. Employee Matters. No Credit Party is engaged in any unfair labor practice that could reasonably be expected to result in a
Material Adverse Change. There is (a) no unfair labor practice complaint pending against any Credit Party, or to the best knowledge of any Credit Party, threatened against any of them before the National Labor Relations Board and no grievance
or arbitration proceeding arising out of or under any collective bargaining agreement that is so pending against any Credit Party or to the best knowledge of any Credit Party, threatened against any of them, (b) no strike or work stoppage in
existence or threatened involving any Credit Party, and (c) to the best knowledge of any Credit Party, no union representation question existing with respect to the employees of 

 

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any Credit Party and, to the best knowledge of any Credit Party, no union organization activity that is taking place, except (with respect to any matter specified in clause (a), (b) or
(c) above, either individually or in the aggregate) such as is not reasonably likely to result in a Material Adverse Change. 

5.16. Use of Proceeds. Borrowers shall use the proceeds of the Credit Extensions solely to fund their general business
requirements and not for personal, family, household or agricultural purposes. 
 5.17. Full Disclosure. No
representation or warranty of any Credit Party contained in any Loan Document or in any other documents, certificates or written statements furnished to the Administrative Agent or Lenders by or on behalf of any Credit Party for use in connection
with the transactions contemplated hereby contains any untrue statement of a material fact or omits to state a material fact (known to any Credit Party, in the case of any document not furnished by it) necessary in order to make the statements
contained herein or therein not misleading in light of the circumstances in which the same were made. Any projections and pro forma financial information contained in such materials are based upon good faith estimates and assumptions believed by the
Credit Party furnishing such materials to be reasonable at the time made. There are no facts known (or which should upon the reasonable exercise of diligence be known) to any Credit Party (other than matters of a general economic nature) that,
individually or in the aggregate, could reasonably be expected to result in a Material Adverse Change and that have not been disclosed herein or in such other documents, certificates and statements furnished to Lenders for use in connection with the
transactions contemplated hereby. 
 5.18. Patriot Act. To the extent applicable, each Credit Party is in compliance, in
all material respects, with the (i) Trading with the Enemy Act, as amended, and each of the foreign assets control regulations of the Untied States Treasury Department (31 CFR, Subtitle B, Chapter V, as amended) and any other enabling
legislation or executive order relating thereto, and (ii) Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism (USA Patriot Act of 2001). No part of the proceeds of the Credit Extensions
will be used, directly or indirectly, for any payments to any governmental official or employee, political party, official of a political party, candidate for political office, or anyone else acting in an official capacity, in order to obtain,
retain or direct business or obtain any improper advantage, in violation of the United States Foreign Corrupt Practices Act of 1977, as amended. 

5.19. Additional Representations and Warranties. The transactions contemplated by those agreements by and among the Credit Parties
pursuant to which the Borrowers became wholly owned Subsidiaries of Guarantor have been consummated in accordance with their respective terms without derivation and the respective representations and warranties of the Credit Parties contained
therein are true, accurate, and complete in all material respects on the Effective Date and on the Funding Date of each Credit Extension; provided, however, that such materiality qualifier shall not be applicable to any representations and
warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material
respects as of such date. 
 5.20. 10/20 Non-Bank Creditor Rules. Nitec’s aggregate number of creditors other than
Qualifying Lenders, under each Term Loan does not exceed 10 (the “10 Non-Bank Creditor Rule”) and its aggregate number of creditors other than Qualifying Lenders under all outstanding loans, facilities and/or private placements
(including under this Agreement) does not exceed 20 (the “20 Non-Bank Creditor Rule”) (as per the explanatory notes of the Swiss Federal Tax Administration S-02.122.1 (4.99), S-02.122.2 (4.99) and S-02.128 (1.2000), as amended,
restated, supplemented or otherwise modified from time to time). 
 6. AFFIRMATIVE COVENANTS 

Each Credit Party covenants and agrees that, until payment in full of all Obligations (other than inchoate indemnity obligations), each
Credit Party shall, and shall cause each of its Subsidiaries to: 
 6.1. Government Compliance. Maintain its and all its
Subsidiaries’ legal existence and good standing in their respective jurisdictions of formation and maintain qualification in each jurisdiction in which the failure to so qualify would reasonably be expected to result in a Material Adverse
Change. Each Credit Party shall comply, and cause each of its Subsidiaries to comply, with all laws, ordinances and regulations to which it is subject, noncompliance with which could reasonably be expected to result in a Material Adverse Change.

  

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 6.2. Financial Statements, Reports, Certificates. Deliver to the Administrative Agent
and each lender: 
 (a) Prior to Completion of an IPO. In the event that no Credit Party is subject to the reporting
requirements under the Exchange Act: 
 (i) Monthly Financial Statements. As soon as available, but in no event later
than the earlier of (A) the date on which they are first delivered to the Board or members of management of Guarantor or (B) thirty (30) days after the last day of each calendar month, (1) a balance sheet and income statement of
each of Guarantor and Horizon, covering each of Guarantor’s and Horizon’s respective operations for such month, in each case, certified by a Responsible Officer and in a form acceptable to the Administrative Agent, (2) aged listings
of accounts receivable and accounts payable (by invoice date), and (3) a statement with respect to each deposit, securities and commodity account of Nitec showing account balances as of the last day of the most recently completed calendar month
(the “Monthly Financial Statements”); 
 (ii) Monthly Compliance Certificate. As soon as available, but
in no event later than the earlier of (A) the date on which they are first delivered to the Board or members of management of Guarantor or (B) thirty (30) days after the last day of each calendar month, and together with the Monthly
Financial Statements, a duly completed Compliance Certificate signed by a Responsible Officer, certifying that as of the end of such month, each Credit Party was in full compliance with all of the terms and conditions of this Agreement; 

(iii) Quarterly Financial Statements of Nitec. As soon as available, but in no event later than the earlier of (A) the date
on which they are first delivered to the Board or members of management of Nitec or (B) thirty (30) days after the last day of each calendar quarter, (1) a balance sheet and income statement of Nitec, covering Nitec’s operations
for such quarter, certified by a Responsible Officer and in a form acceptable to the Administrative Agent, and (2) aged listings of accounts receivable and accounts payable (by invoice date); provided that, upon the earlier of (X) the date
that is thirty (30) days following the last day of the first calendar month for which Nitec has prepared monthly financial statements and (Y) the date that is thirty (30) days following the last day of the sixth full calendar month
following the Effective Date, Nitec shall cease delivering quarterly financial statements pursuant to this clause (iii) and will commence delivering Monthly Financial Statements pursuant to clause (i) above in the same manner as Guarantor
and Horizon; 
 (iv) Quarterly Consolidated Financial Statements. As soon as available, but in no event later than the
earlier of (i) the date on which they are first delivered to the Board or members of management of Guarantor or (ii) thirty (30) days after the last day of each calendar quarter commencing with the calendar quarter ended
September 30, 2010, a Guarantor prepared consolidated balance sheet and consolidating balance sheet as at the end of such period, and consolidated statements, with consolidating statements attached thereto, of profit and loss, cash flow and
change in stockholders equity of Guarantor and its Subsidiaries for such quarterly period certified by a Responsible Officer and in a form acceptable to the Administrative Agent; 

(v) Annual Audited Financial Statements. As soon as available, but in no event later than the earlier of (i) the date on
which they are first delivered to the Board or members of management of Guarantor or (ii) one hundred eighty (180) days after the last day of Guarantor’s fiscal year, commencing with the fiscal year ending December 31, 2010,
audited consolidated financial statements prepared under Applicable Accounting Standards, consistently applied, together with an unqualified opinion on the financial statements from an independent certified public accounting firm acceptable to the
Administrative Agent in its reasonable discretion; 
 (b) After Completion of an IPO. In the event that one or more of
the Credit Parties is subject to the reporting requirements under the Exchange Act: 
 (i) Monthly Financial Statements.
As soon as available, but in no event later than the earlier of (A) the date on which they are first delivered to the Board or members of management of Guarantor or (B) thirty (30) days after the last day of each calendar month,
(1) a balance sheet and income statement of each of Nitec and Horizon, covering each of Nitec’s and Horizon’s respective operations for such month, in each case, certified by a Responsible Officer and in a form acceptable to the
Administrative Agent, and (2) aged listings of accounts receivable and accounts payable (by invoice date); 
  

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 (ii) Monthly Compliance Certificate. As soon as available, but in no event later
than the earlier of (A) the date on which they are first delivered to the Board or members of management of Guarantor or (B) thirty (30) days after the last day of each calendar month, a duly completed Compliance Certificate signed by
a Responsible Officer, certifying that as of the end of such month, each Credit Party was in full compliance with all of the terms and conditions of this Agreement; 

(iii) Quarterly Consolidated Financial Statements. As soon as available, but in no event later than the earlier of (i) the
date on which they are first delivered to the Board or members of management of Guarantor or (ii) forty-five (45) days after the last day of each calendar quarter, a Guarantor prepared consolidated balance sheet and consolidating balance
sheet as at the end of such period, and consolidated statements, with consolidating statements attached thereto, of profit and loss, cash flow and change in stockholders equity of Guarantor and its Subsidiaries for such quarterly period certified by
a Responsible Officer and in a form acceptable to the Administrative Agent; 
 (c) Other Statements. Within five
(5) days of delivery, copies of all statements, reports and notices made available to Guarantor’s security holders or to any holders of Subordinated Debt; 

(d) SEC Filings. In the event that any Credit Party becomes subject to the reporting requirements under the Exchange Act within
five (5) days of filing, copies of all periodic and other reports, proxy statements and other materials filed by such Credit Party with the SEC, any Governmental Authority succeeding to any or all of the functions of the SEC or with any
national securities exchange, or distributed to its shareholders, as the case may be. Documents required to be delivered pursuant to the terms hereof (to the extent any such documents are included in materials otherwise filed with the SEC) may be
delivered electronically and if so delivered, shall be deemed to have been delivered on the date on which such Credit Party posts such documents, or provides a link thereto, on a website on the Internet at a website address provided to the
Administrative Agent; 
 (e) Legal Action Notice. A prompt report of any legal action pending or threatened in writing
against any Credit Party that could result in damages or costs to such Credit Party in an amount in excess of One Hundred Thousand Dollars ($100,000), individually, or Two Hundred and Fifty Thousand Dollars ($250,000), in the aggregate, when
aggregated with all pending or threatened legal actions against all Credit Parties; 
 (f) Board Approved Projections.
Within ten (10) days after Board approval, but at least annually, or more frequently as updated, Board-approved projections and any subsequent amendments thereto; and 

(g) Other Financial Information. Other financial information reasonably requested by the Administrative Agent. 

6.3. Inventory; Returns; Maintenance of Properties. Keep all Inventory in good and marketable condition, free from material
defects. Returns and allowances between each Borrower and its Account Debtors shall follow such Borrower’s customary practices as they exist at the Effective Date. Each Credit Party must promptly notify the Administrative Agent of all returns,
recoveries, disputes and claims that involve more than One Hundred Thousand Dollars ($100,000), individually, or more than Two Hundred and Fifty Thousand Dollars ($250,000), in the aggregate, when aggregated with all other returns, recoveries,
disputes and claims. Each Credit Party will, and will cause each of its Subsidiaries to, maintain or cause to be maintained in good repair, working order and condition, ordinary wear and tear, casualty and condemnation excepted, all material
tangible properties used or useful in its respective business, and from time to time will make or cause to be made all appropriate repairs, renewals and replacements thereof. 

6.4. Taxes; Pensions. Timely file, and require each of its Subsidiaries to timely file, all required Tax returns and reports or
extensions therefor and timely pay, and require each of its Subsidiaries to timely pay, all foreign, federal, state and local Taxes, assessments, deposits and contributions imposed upon it or any of its properties or assets or in respect of any of
its income, businesses or franchises before any penalty or fine accrue thereon, and all claims (including claims for labor, services, materials and supplies) for sums that have become due and payable and that by law have or may become a Lien upon
any of its properties or assets, prior to the time when any penalty or fine shall be incurred with respect thereto; provided, no such Tax or claim need be paid if (i) such Tax or claim does not exceed One Hundred Thousand Dollars
($100,000), individually, or more than Two Hundred and Fifty Thousand Dollars ($250,000), in the aggregate, when aggregated with all other such Taxes or claims, or 

 

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(ii) it is being contested in good faith by appropriate proceedings promptly instituted and diligently conducted, so long as (a) adequate reserve or other appropriate provision, as shall be
required in conformity with Applicable Accounting Standards shall have been made therefor, and (b) in the case of a Tax or claim which has or may become a Lien against any of the Collateral, such contest proceedings conclusively operate to stay
the sale of any portion of the Collateral to satisfy such Tax or claim. Each Credit Party shall deliver to the Administrative Agent, on demand, appropriate certificates attesting to any such payments, and pay all amounts necessary to fund all
present pension, profit sharing and deferred compensation plans in accordance with their terms. No Credit Party will, nor will it permit any of its Subsidiaries to, file or consent to the filing of any consolidated income Tax return with any Person
(other than Borrowers or any of their Subsidiaries). 
 6.5. Insurance. Maintain or cause to be maintained, with
financially sound and reputable insurers, such public liability insurance, third party property damage insurance, business interruption insurance and casualty insurance with respect to liabilities, losses or damage in respect of the assets,
properties and businesses of each Credit Party as may customarily be carried or maintained under similar circumstances by Persons of established reputation engaged in similar businesses, in each case in such amounts, with such deductibles, covering
such risks and otherwise on such terms and conditions as shall be customary for such Persons All property policies shall have a loss payable endorsement showing the Administrative Agent as loss payee and waive subrogation against the Administrative
Agent and shall provide that the insurer must give the Administrative Agent at least twenty (20) days notice before canceling, amending, or declining to renew its policy. All liability policies shall show, or have endorsements showing, the
Administrative Agent as an additional insured, and all such policies (or the loss payable and additional insured endorsements) shall provide that the insurer shall give the Administrative Agent at least twenty (20) days notice before canceling,
amending, or declining to renew its policy. At the Administrative Agent’s request, each Credit Party shall deliver certified copies of policies and evidence of all premium payments. If any Credit Party fails to obtain insurance as required
under this Section 6.5 or to pay any amount or furnish any required proof of payment to third persons and the Administrative Agent, the Administrative Agent may make all or part of such payment or obtain such insurance policies required
in this Section 6.5, and take any action under the policies the Administrative Agent deems prudent. 
 6.6.
Operating Accounts. 
 (a) Maintain all and all of its Subsidiaries’ operating, depository, and securities accounts with
Silicon Valley Bank or any of its Affiliates; provided that Nitec shall maintain all of its and its Subsidiaries’ operating, depository, and securities accounts with Credit Suisse AG, Basler Kantonalbank, Basellandshaftliche Kantonalbank,
Sparkasse Rhein Neckar Nord, and Deutsche Apotheker-und Arztebank (the “Permitted Accounts”), and which accounts maintained by Nitec shall be subject to the grant to the Administrative Agent, for the ratable benefit of the Lenders,
of a security interest which has been perfected in accordance with applicable law. No Credit Party shall establish an operating, depository, or securities account, other than any such accounts maintained at Silicon Valley Bank or any of its
Affiliates or the Permitted Accounts, unless contemporaneously with such establishment, such account is subject to either (i) a Control Agreement or (ii) the grant to the Administrative Agent, for the ratable benefit of the Lenders, of a
security interest which has been perfected in accordance with applicable law, as applicable. 
 (b) Provide the Administrative
Agent five (5) days prior written notice before establishing any Collateral Account at or with any bank or financial institution other than Silicon Valley Bank or any of its Affiliates. For each Collateral Account that each Credit Party at any
time maintains, such Credit Party shall cause the applicable bank or financial institution (other than the Administrative Agent) at or with which any Collateral Account is maintained to execute and deliver a Control Agreement or other appropriate
instrument with respect to such Collateral Account to perfect the Administrative Agent’s Lien in such Collateral Account in accordance with the terms hereunder which Control Agreement may not be terminated without the prior written consent of
the Administrative Agent. The provisions of the previous sentence shall not apply to deposit accounts exclusively used for payroll, payroll Taxes and other employee wage and benefit payments to or for the benefit of any Credit Party’s employees
and identified to the Administrative Agent by such Credit Party as such. 
 (c) Notwithstanding the foregoing Sections 6.6(a)
and (b), each of Guarantor and Horizon is permitted (i) for a period not exceeding thirty (30) days after the Effective Date, to maintain its current Collateral Accounts with financial institutions other than Silicon Valley Bank or its
Affiliates and (ii) for a period not 
  

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exceeding sixty days after the Effective Date, to maintain its employee credit card program with a financial institution other than Silicon Valley Bank or its Affiliates. 

6.7. Protection of Intellectual Property Rights. 

(a) (i) Protect, defend and maintain the validity and enforceability of its Intellectual Property; (ii) promptly advise the
Administrative Agent in writing of material infringements of its Intellectual Property; and (iii) not allow any Intellectual Property material to its business to be abandoned, forfeited or dedicated to the public without the Administrative
Agent’s written consent. 
 (b) Provide written notice to the Administrative Agent within thirty (30) days of entering
or becoming bound by any Restricted License (other than over-the-counter software that is commercially available to the public). Each Credit Party shall take such commercially reasonable steps as the Administrative Agent requests to obtain the
consent of, or waiver by, any person whose consent or waiver is necessary for (i) any Restricted License to be deemed “Collateral” and for the Administrative Agent to have a security interest in it that might otherwise be restricted
or prohibited by law or by the terms of any such Restricted License, whether now existing or entered into in the future, and (ii) the Administrative Agent to have the ability in the event of a liquidation of any Collateral to dispose of such
Collateral in accordance with the Administrative Agent’s rights and remedies under this Agreement and the other Loan Documents. 

6.8. Litigation Cooperation. From the date hereof and continuing through the termination of this Agreement, make available to the
Administrative Agent, without expense to the Administrative Agent, each Credit Party and its officers, employees and agents and such Credit Party’s books and records, to the extent that the Administrative Agent may deem them reasonably
necessary to prosecute or defend any third-party suit or proceeding instituted by or against the Administrative Agent with respect to any Collateral or relating to such Credit Party. 

6.9. Access to Collateral; Books and Records. Allow the Administrative Agent, or its agents, at reasonable times, on one
(1) Business Day’s notice (provided no notice is required if an Event of Default has occurred and is continuing), to inspect the Collateral and audit and copy any Credit Party’s Books. The foregoing inspections and audits shall be at
the relevant Credit Party’s expense. Such inspections or audits shall be conducted no more often than once every twelve (12) months unless an Event of Default has occurred and is continuing. 

6.10. Lenders Meetings. Upon the request of Administrative Agent or Requisite Lenders, participate in a meeting of Administrative
Agent and Lenders once during each fiscal year to be held at Borrowers’ corporate offices (or at such other location as may be agreed to by Borrowers and Administrative Agent) at such time as may be agreed to by Borrowers and Administrative
Agent. 
 6.11. Environmental. 

(a) Environmental Disclosure. Deliver to Administrative Agent: 

(i) as soon as practicable following receipt thereof, copies of all environmental audits, investigations, analyses and reports of any
kind or character, whether prepared by personnel of any Credit Party or by independent consultants, governmental authorities or any other Persons, with respect to significant environmental matters at any Facility or with respect to any material
Environmental Claims; 
 (ii) promptly upon an officer of any Credit Party obtaining knowledge of the occurrence thereof,
written notice describing in reasonable detail (1) any Release required to be reported to any federal, state or local governmental or regulatory agency under any applicable Environmental Laws, (2) any remedial action taken by any Credit
Party or any other Person in response to (A) any Hazardous Materials Activities the existence of which has a reasonable possibility of resulting in one or more Environmental Claims resulting in, individually or in the aggregate, a Material
Adverse Change, or (B) any Environmental Claims that, individually or in the aggregate, have a reasonable possibility of resulting in a Material Adverse Change, and (3) any Credit Party’s discovery of any occurrence or condition on
any real property adjoining or in the vicinity of any Facility that could cause such Facility or any part thereof to be 

 

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subject to any material restrictions on the ownership, occupancy, transferability or use thereof under any Environmental Laws; 

(iii) as soon as practicable following the sending or receipt thereof by any Credit Party, a copy of any and all written communications
with respect to (1) any Environmental Claims that, individually or in the aggregate, have a reasonable possibility of resulting in a Material Adverse Change, (2) any Release required to be reported to any federal, state or local
governmental or regulatory agency, and (3) any request for information from any governmental agency that suggests such agency is investigating whether any Credit Party or any of its Subsidiaries may be potentially responsible for any Hazardous
Materials Activity that, individually or in the aggregate, has a reasonable possibility of resulting in a Material Adverse Change; 

(iv) prompt written notice describing in reasonable detail (1) any proposed acquisition of stock, assets, or property by any Credit
Party that could reasonably be expected to (A) expose any Credit Party to, or result in, Environmental Claims that could reasonably be expected to result in, individually or in the aggregate, a Material Adverse Change or (B) affect the
ability of any Credit Party to maintain in full force and effect all material Governmental Authorizations required under any Environmental Laws for their respective operations and (2) any proposed action to be taken by any Credit Party to
modify current operations in a manner that could reasonably be expected to subject any Credit Party to any additional material obligations or requirements under any Environmental Laws; and 

(v) with reasonable promptness, such other documents and information as from time to time may be reasonably requested by Administrative
Agent in relation to any matters disclosed pursuant to this Section 6.11(a). 
 (b) Hazardous Materials Activities,
Etc. Each Credit Party shall promptly take any and all actions necessary to (i) cure any violation of applicable Environmental Laws by such Credit Party that could reasonably be expected to result in, individually or in the aggregate, a
Material Adverse Change, and (ii) make an appropriate response to any Environmental Claim against such Credit Party and discharge any obligations it may have to any Person thereunder where failure to do so could reasonably be expected to result
in, individually or in the aggregate, a Material Adverse Change. 
 6.12. Further Assurances. At any time or from time to
time upon the request of the Administrative Agent, each Credit Party will, at its expense, promptly execute, acknowledge and deliver such further documents and do such other acts and things as the Administrative Agent may reasonably request in order
to effect fully the purposes of the Loan Documents. 
 6.13. 10/20 Non-Bank Creditor Rules. Nitec undertakes to comply
with the 10 Non-Bank Creditor Rule and the 20 Non-Bank Creditor Rule. 
 7. NEGATIVE COVENANTS 

Each Credit Party covenants and agrees that, until payment in full of all Obligations (other than inchoate indemnity obligations), such
Credit Party shall not, and shall cause each of its Subsidiaries not to: 
 7.1. Dispositions. Convey, sell, lease,
transfer, assign, or otherwise dispose of (collectively, “Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of its business or property, except (a) for Transfers of Inventory in the ordinary course of
business; (b) for Transfers of worn out or obsolete Equipment; (c) Permitted Licenses; and (d) in connection with Permitted Liens and Permitted Investments. 

7.2. Changes in Business, Management, Ownership, or Business Locations. (a) Engage in or permit any of its Subsidiaries to
engage in any business other than the businesses currently engaged in by it and such Subsidiary, as applicable, or reasonably related thereto; (b) liquidate or dissolve; or (c) (i) have a change in senior management and a replacement
satisfactory to such Credit Party’s Board is not made within ninety (90) days after such person’s departure; or (ii) enter into any transaction or series of related transactions in which the stockholders of any Credit Party who
were not stockholders immediately prior to the first such transaction own more than 40% of the voting stock of such Credit Party immediately after giving effect to such transaction or related series of such

  

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transactions (other than by the sale of such Credit Party’s equity securities in a public offering or to venture capital investors so long as such Credit Party identifies to the
Administrative Agent the venture capital investors prior to the closing of the transaction and provides to the Administrative Agent a description of the material terms of the transaction). 

No Credit Party shall, without at least thirty (30) days prior written notice to the Administrative Agent: (1) add any new
office or business location, including a warehouse (unless such new office or business location contains less than One Hundred Thousand Dollars ($100,000) in such Credit Party’s assets or property ) or deliver any portion of the Collateral
valued, individually in excess of One Hundred Thousand Dollars ($100,000) or, in the aggregate, in excess of Two Hundred and Fifty Thousand Dollars ($250,000) to a bailee at a location other than to a bailee and at a location already disclosed in
the Perfection Certificate, (2) change its jurisdiction of organization, (3) change its organizational structure or type, (4) change its legal name, or (5) change any organizational number (if any) assigned by its jurisdiction of
organization. If any Credit Party intends to deliver any portion of the Collateral valued, individually or in the aggregate, in excess of Two Hundred and Fifty Thousand ($250,000) to a bailee, and the Administrative Agent and such bailee are not
already parties to a bailee agreement governing both the Collateral and the location to which such Credit Party intends to deliver the Collateral, then such Credit Party will first receive the written consent of the Administrative Agent, and such
bailee shall execute and deliver a bailee agreement in form and substance reasonably satisfactory to the Administrative Agent. Notwithstanding the foregoing, notice with respect to the change of the legal name of Nitec Pharma AG to Horizon Pharma AG
and of Nitec Pharma GmbH to Horizon Pharma GmbH, to be effected no later than April 30, 2010, shall be deemed to have been given in satisfaction of the foregoing sentence with respect to such changes; provided that Nitec shall provide written
notice to the Administrative Agent within two (2) Business Days following the effectiveness of each such name change. 

7.3. Mergers or Acquisitions. Merge or consolidate, or permit any of its Subsidiaries to merge or consolidate, with any other
Person, or acquire, or permit any of its Subsidiaries to acquire, all or substantially all of the capital stock or property of another Person. A Subsidiary may merge or consolidate into another Subsidiary or into any Credit Party. 

7.4. Indebtedness. Directly or indirectly, create, incur, assume or guaranty, or otherwise become or remain directly or indirectly
liable with respect to any Indebtedness, other than Permitted Indebtedness. 
 7.5. Encumbrance. Except for Permitted
Liens, create, incur, allow, or suffer any Lien on any of its property, or assign or convey any right to receive income, including the sale of any Accounts, or permit any of its Subsidiaries to do so, or permit any Collateral not to be subject to
the first priority security interest granted herein. Notwithstanding the foregoing, promptly following the later of receipt by the Administrative Agent of evidence reasonably satisfactory to the Administrative Agent of the completion by Guarantor of
a Qualified IPO or the issuance by the FDA of marketing approval for either Lodotra or Duexa, the restriction in the foregoing sentence shall no longer apply with respect to the Intellectual Property Collateral; provided that the restriction
contained in the foregoing sentence shall continue to apply with respect to the IP Collateral Proceeds. 
 7.6. No Further
Negative Pledges; Negative Pledge. 
 (a) Except with respect to (i) specific property encumbered to secure payment of
particular Indebtedness, (ii) restrictions by reason of customary provisions restricting assignments, subletting or other transfers contained in leases, licenses and similar agreements entered into in the ordinary course of business (provided
that such restrictions are limited to the property or assets secured by such Liens or the property or assets subject to such leases, licenses or similar agreements, as the case may be), and (iii) the Existing Kreos Loan Agreement, no Credit
Party nor any of its Subsidiaries shall enter into any agreement prohibiting the creation or assumption of any Lien upon any of its properties or assets, whether now owned or hereafter acquired, to secure the Obligations. Notwithstanding the
foregoing, promptly following the later of receipt by the Administrative Agent of evidence reasonably satisfactory to the Administrative Agent of the completion by Guarantor of a Qualified IPO or the issuance by the FDA of marketing approval for
either Lodotra or Duexa, the restriction in the foregoing sentence shall no longer apply with respect to the Intellectual Property Collateral. 

(b) No Credit Party will sell, assign, transfer, exchange or otherwise dispose of any Equity Interests issued by any Subsidiary which are
owned or otherwise held by such Credit Party, except for sales, 
  

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assignments, transfers, exchanges or other dispositions to another Credit Party or to qualify directors if required by applicable law; provided that, in the case of sales, assignments, transfers,
exchanges or other dispositions to qualify directors as required by applicable law, such sale, assignment, transfer, exchange or other disposition shall be for the minimum number of Equity Interests as are necessary for such qualification under
applicable law. No Credit Party will create, incur, assume or suffer to exist, any Lien on the Equity Interests issued by any Subsidiary which are owned or otherwise held by such Credit Party, except for any Lien or claim in favor of Administrative
Agent. 
 7.7. Maintenance of Collateral Accounts. Maintain any Collateral Account except pursuant to the terms of
Section 6.6 hereof. 
 7.8. Distributions, Investments. (a) Pay any dividends or make any distribution
or payment or redeem, retire or purchase any capital stock; provided that (i) Guarantor may convert any of its convertible securities into other securities pursuant to the terms of such convertible securities or otherwise in exchange thereof,
(ii) Guarantor may pay dividends solely in common stock; and (iii) Guarantor may repurchase the stock of former employees, directors or consultants pursuant to stock repurchase agreements so long as (A) an Event of Default does not
exist at the time of such repurchase and would not exist after giving effect to such repurchase and (B) the amount paid for all such repurchases shall not exceed One Hundred Thousand Dollars ($100,000), in the aggregate, in any twelve
(12) month period, or (b) directly or indirectly make any Investment other than Permitted Investments, or permit any of its Subsidiaries to do so. Notwithstanding the foregoing, Borrowers shall be permitted to pay dividends or make
distributions to Guarantor, and Subsidiaries of Borrowers shall be permitted to pay dividends or make distributions to Borrowers. 

7.9. Restrictions on Subsidiary Distributions. Except as provided herein, create or otherwise cause or suffer to exist or become
effective any consensual encumbrance or restriction of any kind on the ability of any Subsidiary of Borrowers to (a) pay dividends or make any other distributions on any of such Subsidiary’s Equity Interests owned by Borrowers or any other
Subsidiary of Borrowers, (b) repay or prepay any Indebtedness owed by such Subsidiary to Borrowers or any other Subsidiary of Borrowers, (c) make loans or advances to Borrowers or any other Subsidiary of Borrowers, or (d) transfer,
lease or license any of its property or assets to Borrowers or any other Subsidiary of Borrowers other than restrictions (i) by reason of customary provisions restricting assignments, subletting or other transfers contained in leases, licenses,
joint venture agreements and similar agreements entered into in the ordinary course of business, (ii) that are or were created by virtue of any transfer of, agreement to transfer or option or right with respect to any property, assets or Equity
Interests not otherwise prohibited under this Agreement that impose restrictions on such Equity Interests or assets or (iii) that exist under or by reason of applicable law. 

7.10. Disposal of Subsidiary Interests. Directly or indirectly sell, assign, pledge or otherwise encumber or dispose of any Equity
Interests of any of its Subsidiaries, except to qualify directors if required by applicable law. 
 7.11. Transactions with
Affiliates. Directly or indirectly enter into or permit to exist any material transaction with any Affiliate of any Credit Party, except for (a) transactions that are in the ordinary course of such Credit Party’s business, upon fair
and reasonable terms that are no less favorable to such Credit Party than would be obtained in an arm’s length transaction with a non-affiliated Person, (b) Investments permitted under sub-clauses (f) or (g) of the definition of
Permitted Investments, and (c) Investments in Guarantor comprised of the proceeds of equity financings and unsecured debt financings from Guarantor’s investors, so long as all such Indebtedness is Subordinated Debt. 

7.12. Subordinated Debt. (a) Make or permit any payment on any Subordinated Debt, except under the terms of the
subordination, intercreditor, or other similar agreement to which such Subordinated Debt is subject, or (b) amend any provision in any document relating to the Subordinated Debt which would increase the amount thereof, except under the terms of
the subordination, intercreditor, or other similar agreement to which such Subordinated Debt is subject, or adversely affect the subordination thereof to Obligations owed to the Lenders. 

7.13. Amendments or Waivers of Organizational Documents. Agree to any amendment, restatement, supplement or other modification to,
or waiver of, any of its Operating Documents in a manner that would adversely affect its ability to perform its obligations under the Loan Documents or adversely affect the rights, 

 

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remedies and benefits available to, or conferred upon, the Administrative Agent or any Lender under any Loan Document. 

7.14. Fiscal Year. Except as disclosed on Schedule 7.14 hereto, no Credit Party shall, nor shall it permit any of its
Subsidiaries to change its fiscal year, except that shortly after the Effective Date, Nitec and its wholly owned subsidiary, Nitec Pharma GmbH, intend to change their fiscal year from a fiscal year ending on June 30 to a fiscal year ending on
December 31. 
 7.15. Compliance. Become an “investment company” or a company controlled by an
“investment company”, under the Investment Company Act of 1940, as amended, or undertake as one of its important activities extending credit to purchase or carry margin stock (as defined in Regulation U of the Board of Governors of the
Federal Reserve System), or use the proceeds of any Credit Extension for that purpose; fail to meet the minimum funding requirements of ERISA, permit a Reportable Event or Prohibited Transaction, as defined in ERISA, to occur; fail to comply with
the Federal Fair Labor Standards Act or violate any other law or regulation, if the violation could reasonably be expected to have a material adverse effect on its business, or permit any of its Subsidiaries to do so; withdraw or permit any
Subsidiary to withdraw from participation in, permit partial or complete termination of, or permit the occurrence of any other event with respect to, any present pension, profit sharing and deferred compensation plan which could reasonably be
expected to result in any liability of such Credit Party, including any liability to the Pension Benefit Guaranty Corporation or its successors or any other governmental agency. 

7.16. Non-Guarantor Subsidiaries. Subject to Section 4.2(c), no Credit Party shall permit the assets of any of its
Subsidiaries to exceed One Million Dollars $1,000,000, in the aggregate, unless and until such Subsidiary (a) is or becomes a co-borrower or a guarantor hereunder and (b) has granted to the Administrative Agent, for the ratable benefit of
the Lenders, a security interest in all of its assets, which security interest has been perfected in accordance with applicable law. 

8. GUARANTY 

8.1. Guaranty of the Obligations. Guarantor hereby irrevocably and unconditionally guaranties to the Administrative Agent, for the
ratable benefit of the Lenders, the due and punctual payment in full of all Obligations when the same shall become due, whether at stated maturity, by required prepayment, declaration, acceleration, demand or otherwise (including amounts that would
become due but for the operation of the automatic stay under Section 362(a) of the Bankruptcy Code, 11 U.S.C. § 362(a)) (collectively, the “Guaranteed Obligations”). 

8.2. Payment By Guarantor. Guarantor hereby agrees, in furtherance of the foregoing and not in limitation of any other right which
the Administrative Agent or any Lender may have at law or in equity against Guarantor by virtue hereof, that upon the failure of Borrowers to pay any of the Guaranteed Obligations when and as the same shall become due, whether at stated maturity, by
required prepayment, declaration, acceleration, demand or otherwise (including amounts that would become due but for the operation of the automatic stay under Section 362(a) of the Bankruptcy Code, 11 U.S.C. § 362(a)), Guarantor will upon
demand pay, or cause to be paid, in cash, to the Administrative Agent, for the ratable benefit of the Lenders, an amount equal to the sum of the unpaid principal amount of all Guaranteed Obligations then due as aforesaid, accrued and unpaid interest
on such Guaranteed Obligations (including interest which, but for Borrowers becoming the subject of a case under the Bankruptcy Code, would have accrued on such Guaranteed Obligations, whether or not a claim is allowed against Borrowers for such
interest in the related bankruptcy case) and all other Guaranteed Obligations then owed to the Administrative Agent or the Lenders as aforesaid. 

8.3. Liability of Guarantor Absolute. Guarantor agrees that its obligations hereunder are irrevocable, absolute, independent and
unconditional and shall not be affected by any circumstance which constitutes a legal or equitable discharge of a guarantor or surety other than payment in full of the Guaranteed Obligations. In furtherance of the foregoing and without limiting the
generality thereof, Guarantor agrees as follows: 
 (a) this Guaranty is a guaranty of payment when due and not of
collectability. This Guaranty is a primary obligation of Guarantor and not merely a contract of surety; 
  

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 (b) the Administrative Agent may enforce this Guaranty upon the occurrence of an Event of
Default notwithstanding the existence of any dispute between Borrowers and the Administrative Agent and/or any Lender with respect to the existence of such Event of Default; 

(c) the obligations of Guarantor hereunder are independent of the obligations of Borrowers and the obligations of any other guarantor of
the obligations of Borrowers, and a separate action or actions may be brought and prosecuted against Guarantor whether or not any action is brought against Borrowers or any of such other guarantors and whether or not Borrowers are joined in any such
action or actions; 
 (d) payment by Guarantor of a portion, but not all, of the Guaranteed Obligations shall in no way limit,
affect, modify or abridge Guarantor’s liability for any portion of the Guaranteed Obligations which has not been paid. Without limiting the generality of the foregoing, if the Administrative Agent is awarded a judgment in any suit brought to
enforce Guarantor’s covenant to pay a portion of the Guaranteed Obligations, such judgment shall not be deemed to release Guarantor from its covenant to pay the portion of the Guaranteed Obligations that is not the subject of such suit;

 (e) the Administrative Agent, upon such terms as it deems appropriate, without notice or demand and without affecting the
validity or enforceability hereof or giving rise to any reduction, limitation, impairment, discharge or termination of Guarantor’s liability hereunder, but without limiting Borrowers’ rights hereunder, from time to time may (i) renew,
extend, accelerate, increase the rate of interest on, or otherwise change the time, place, manner or terms of payment of the Guaranteed Obligations; (ii) settle, compromise, release or discharge, or accept or refuse any offer of performance
with respect to, or substitutions for, the Guaranteed Obligations or any agreement relating thereto and/or subordinate the payment of the same to the payment of any other obligations; (iii) request and accept other guaranties of the Guaranteed
Obligations and take and hold security for the payment hereof or the Guaranteed Obligations; (iv) release, surrender, exchange, substitute, compromise, settle, rescind, waive, alter, subordinate or modify, with or without consideration, any
security for payment of the Guaranteed Obligations, any other guaranties of the Guaranteed Obligations, or any other obligation of any Person with respect to the Guaranteed Obligations; (v) enforce and apply any security now or hereafter held
by or for the benefit of the Administrative Agent and/or any Lender in respect hereof or the Guaranteed Obligations and direct the order or manner of sale thereof, or exercise any other right or remedy that the Administrative Agent and/or any Lender
may have against any such security, in each case as the Administrative Agent in its discretion may determine consistent herewith and any applicable security agreement, including foreclosure on any such security pursuant to one or more judicial or
nonjudicial sales, whether or not every aspect of any such sale is commercially reasonable, and even though such action operates to impair or extinguish any right of reimbursement or subrogation or other right or remedy of Guarantor against
Borrowers or any security for the Guaranteed Obligations; and (vi) exercise any other rights available to it under the Loan Documents; and 

(f) this Guaranty and the obligations of Guarantor hereunder shall be valid and enforceable and shall not be subject to any reduction,
limitation, impairment, discharge or termination for any reason (other than payment in full of the Guaranteed Obligations), including the occurrence of any of the following, whether or not Guarantor shall have had notice or knowledge of any of them:
(i) any failure or omission to assert or enforce or agreement or election not to assert or enforce, or the stay or enjoining, by order of court, by operation of law or otherwise, of the exercise or enforcement of, any claim or demand or any
right, power or remedy (whether arising under the Loan Documents, at law, in equity or otherwise) with respect to the Guaranteed Obligations or any agreement relating thereto, or with respect to any other guaranty of or security for the payment of
the Guaranteed Obligations; (ii) any rescission, waiver, amendment or modification of, or any consent to departure from, any of the terms or provisions (including provisions relating to events of default) hereof, any of the other Loan Documents
or any agreement or instrument executed pursuant thereto, or of any other guaranty or security for the Guaranteed Obligations, in each case whether or not in accordance with the terms hereof or such Loan Document or any agreement relating to such
other guaranty or security; (iii) the Guaranteed Obligations, or any agreement relating thereto, at any time being found to be illegal, invalid or unenforceable in any respect; (iv) the application of payments received from any source
(other than payments received pursuant to the other Loan Documents or from the proceeds of any security for the Guaranteed Obligations, except to the extent such security also serves as collateral for indebtedness other than the Guaranteed
Obligations) to the payment of indebtedness other than the Guaranteed Obligations, even though the Administrative Agent and/or any Lender might have elected to apply such payment to any part or all of the Guaranteed Obligations; (v) the
Administrative Agent’s and/or any Lender’s consent to the change, reorganization or termination of the corporate structure or existence of any Borrower or any 

 

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of its Subsidiaries and to any corresponding restructuring of the Guaranteed Obligations; (vi) any failure to perfect or continue perfection of a Lien in any collateral which secures any of
the Guaranteed Obligations; (vii) any defenses, set offs or counterclaims which Borrowers may allege or assert against the Administrative Agent and/or any Lender in respect of the Guaranteed Obligations, including failure of consideration,
breach of warranty, payment, statute of frauds, statute of limitations, accord and satisfaction and usury; and (viii) any other act or thing or omission, or delay to do any other act or thing, which may or might in any manner or to any extent
vary the risk of any Guarantor as an obligor in respect of the Guaranteed Obligations. 
 8.4. Waivers by Guarantor.
Guarantor hereby waives, for the benefit of the Administrative Agent and/or the Lenders: (a) any right to require the Administrative Agent and/or the Lenders, as a condition of payment or performance by Guarantor, to (i) proceed against
Borrowers, any other guarantor of the Guaranteed Obligations or any other Person, (ii) proceed against or exhaust any security held from Borrowers, any such other guarantor or any other Person, (iii) proceed against or have resort to any
balance of any Deposit Account or credit on the books of the Administrative Agent and/or any Lender in favor of Borrowers or any other Person, or (iv) pursue any other remedy in the power of the Administrative Agent and/or any Lender
whatsoever; (b) any defense arising by reason of the incapacity, lack of authority or any disability or other defense of Borrowers or any other guarantor including any defense based on or arising out of the lack of validity or the
unenforceability of the Guaranteed Obligations or any agreement or instrument relating thereto or by reason of the cessation of the liability of Borrowers or any other guarantor from any cause other than payment in full of the Guaranteed
Obligations; (c) any defense based upon any statute or rule of law which provides that the obligation of a surety must be neither larger in amount nor in other respects more burdensome than that of the principal; (d) any defense based upon
the Administrative Agent’s and/or any Lender ‘s errors or omissions in the administration of the Guaranteed Obligations, except behavior which amounts to bad faith; (e) (i) any principles or provisions of law, statutory or
otherwise, which are or might be in conflict with the terms hereof and any legal or equitable discharge of Guarantor’s obligations hereunder, (ii) the benefit of any statute of limitations affecting Guarantor’s liability hereunder or
the enforcement hereof, (iii) any rights to set offs, recoupments and counterclaims, and (iv) promptness, diligence and any requirement that the Administrative Agent and/or any Lender protect, secure, perfect or insure any Lien or any
property subject thereto; (f) notices, demands, presentments, protests, notices of protest, notices of dishonor and notices of any action or inaction, including acceptance hereof, notices of default hereunder or any agreement or instrument
related hereto, notices of any renewal, extension or modification of the Guaranteed Obligations or any agreement related thereto, notices of any extension of credit to Borrowers and notices of any of the matters referred to in
Section 8.3 and any right to consent to any thereof; and (g) any defenses or benefits that may be derived from or afforded by law which limit the liability of or exonerate guarantors or sureties, or which may conflict with the terms
hereof. 
 8.5. Guarantor’s Rights of Subrogation, Contribution, etc. Until the Guaranteed Obligations shall have
been indefeasibly paid in full and the Term Commitments shall have terminated, Guarantor hereby waives any claim, right or remedy, direct or indirect, that Guarantor now has or may hereafter have against Borrowers or any other guarantor or any of
its assets in connection with this Guaranty or the performance by Guarantor of its obligations hereunder, in each case whether such claim, right or remedy arises in equity, under contract, by statute, under common law or otherwise and including
(a) any right of subrogation, reimbursement or indemnification that Guarantor now has or may hereafter have against Borrowers with respect to the Guaranteed Obligations, (b) any right to enforce, or to participate in, any claim, right or
remedy that the Administrative Agent and/or any Lender now has or may hereafter have against Borrowers, and (c) any benefit of, and any right to participate in, any collateral or security now or hereafter held by the Administrative Agent and/or
any Lender. In addition, until the Guaranteed Obligations shall have been indefeasibly paid in full and the Term Commitments shall have terminated, Guarantor shall withhold exercise of any right of contribution Guarantor may have against any other
guarantor of the Guaranteed Obligations. Guarantor further agrees that, to the extent the waiver or agreement to withhold the exercise of its rights of subrogation, reimbursement, indemnification and contribution as set forth herein is found by a
court of competent jurisdiction to be void or voidable for any reason, any rights of subrogation, reimbursement or indemnification Guarantor may have against Borrowers or against any collateral or security, and any rights of contribution Guarantor
may have against any such other guarantor, shall be junior and subordinate to any rights the Administrative Agent and/or any Lender may have against Borrowers, to all right, title and interest the Administrative Agent and/or any Lender may have in
any such collateral or security, and to any right the Administrative Agent and/or any Lender may have against such other guarantor. If any amount shall be paid to Guarantor on account of any such subrogation, reimbursement, indemnification or
contribution rights at any time when all Guaranteed Obligations shall not have been finally and indefeasibly paid in full, such amount shall be held in trust for the Administrative Agent, for the ratable benefit of the Lenders, and shall forthwith
be paid over to the 
  

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Administrative Agent for the ratable benefit of the Lenders to be credited and applied against the Guaranteed Obligations, whether matured or unmatured, in accordance with the terms hereof.

 8.6. Subordination of Other Obligations. Except as provided in the following sentence, any Indebtedness of Borrowers
now or hereafter held by Guarantor (the “Obligee Guarantor”) is hereby subordinated in right of payment to the Guaranteed Obligations, and any such Indebtedness collected or received by the Obligee Guarantor after an Event of
Default has occurred and is continuing shall be held in trust for the Administrative Agent, for the ratable benefit of the Lenders, and shall forthwith be paid over to the Administrative Agent, for the ratable benefit of the Lenders, to be credited
and applied against the Guaranteed Obligations but without affecting, impairing or limiting in any manner the liability of the Obligee Guarantor under any other provision hereof 

8.7. Continuing Guaranty. This Guaranty is a continuing guaranty and shall remain in effect until all of the Guaranteed
Obligations shall have been paid in full and the Term Commitments shall have terminated. Guarantor hereby irrevocably waives any right to revoke this Guaranty as to future transactions giving rise to any Guaranteed Obligations. 

8.8. Authority of Guarantor or Borrowers. It is not necessary for the Administrative Agent and/or any Lender to inquire into the
capacity or powers of Guarantor or Borrowers or the officers, directors or any agents acting or purporting to act on behalf of any of them. 

8.9. Financial Condition of Borrowers. Any Credit Extension may be made to Borrowers or continued from time to time without notice
to or authorization from Guarantor regardless of the financial or other condition of Borrowers at the time of any such grant or continuation. Neither the Administrative Agent nor any Lender shall have any obligation to disclose or discuss with
Guarantor its assessment, or Guarantor’s assessment, of the financial condition of Borrowers. Guarantor has adequate means to obtain information from Borrowers on a continuing basis concerning the financial condition of Borrowers and their
ability to perform their obligations under the Loan Documents, and Guarantor assumes the responsibility for being and keeping informed of the financial condition of Borrowers and of all circumstances bearing upon the risk of nonpayment of the
Guaranteed Obligations. Guarantor hereby waives and relinquishes any duty on the part of the Administrative Agent and/or any Lender to disclose any matter, fact or thing relating to the business, operations or conditions of Borrowers now known or
hereafter known by the Administrative Agent and/or any Lender. 
 8.10. Bankruptcy, etc. 

(a) So long as any Guaranteed Obligations remain outstanding, Guarantor shall not, without the prior written consent of Administrative
Agent acting pursuant to the instructions of Requisite Lenders, commence or join with any other Person in commencing any bankruptcy, reorganization or insolvency case or proceeding of or against Borrowers. The obligations of Guarantor hereunder
shall not be reduced, limited, impaired, discharged, deferred, suspended or terminated by any case or proceeding, voluntary or involuntary, involving the bankruptcy, insolvency, receivership, reorganization, liquidation or arrangement of Borrowers
or by any defense which Borrowers may have by reason of the order, decree or decision of any court or administrative body resulting from any such proceeding. 

(b) Guarantor acknowledges and agrees that any interest on any portion of the Guaranteed Obligations which accrues after the commencement
of any case or proceeding referred to in clause (a) above (or, if interest on any portion of the Guaranteed Obligations ceases to accrue by operation of law by reason of the commencement of such case or proceeding, such interest as would have
accrued on such portion of the Guaranteed Obligations if such case or proceeding had not been commenced) shall be included in the Guaranteed Obligations because it is the intention of Guarantor, the Administrative Agent and/or the Lenders that the
Guaranteed Obligations which are guaranteed by Guarantor pursuant hereto should be determined without regard to any rule of law or order which may relieve Borrowers of any portion of such Guaranteed Obligations. Guarantor will permit any trustee in
bankruptcy, receiver, debtor in possession, assignee for the benefit of creditors or similar Person to pay the Administrative Agent, or allow the claim of Administrative Agent in respect of, any such interest accruing after the date on which such
case or proceeding is commenced. 
 (c) In the event that all or any portion of the Guaranteed Obligations are paid by
Borrowers, the obligations of Guarantor hereunder shall continue and remain in full force and effect or be reinstated, as the case 

 

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may be, in the event that all or any part of such payment(s) are rescinded or recovered directly or indirectly from the Administrative Agent and/or any Lender as a preference, fraudulent transfer
or otherwise, and any such payments which are so rescinded or recovered shall constitute Guaranteed Obligations for all purposes hereunder. 

8.11. Discharge of Guaranty Upon Sale of Guarantor. If all of the Equity Interests of Guarantor or any of its successors in
interest hereunder shall be sold or otherwise disposed of (including by merger or consolidation) in accordance with the terms and conditions hereof, the Guaranty of Guarantor or such successor in interest, as the case may be, hereunder shall
automatically be discharged and released without any further action by the Administrative Agent and/or any Lender or any other Person effective as of the time of such sale or disposition. 

9. EVENTS OF DEFAULT 

Any one of the following shall constitute an event of default (an “Event of Default”) under this Agreement: 

9.1. Payment Default. Any Credit Party fails to (a) make any payment of principal or interest on any Credit Extension on its
due date, or (b) pay any other Obligations within three (3) Business Days after such Obligations are due and payable (which three (3) Business Day cure period shall not apply to payments due on the Term Loan Maturity Date). During the
cure period, the failure to make or pay any payment specified under clause (a) or (b) hereunder is not an Event of Default (but no Credit Extension will be made during the cure period); 

9.2. Covenant Default. 

(a) The Credit Parties fail or neglect to perform any obligation in Sections 6.2, 6.4, 6.5, 6.6, 6.7(b)
or violate any covenant in Section 7; or 
 (b) The Credit Parties fail or neglect to perform, keep, or observe any
other term, provision, condition, covenant or agreement contained in this Agreement or any Loan Documents, and as to any default (other than those specified in this Section 9) under such other term, provision, condition, covenant or
agreement that can be cured, have failed to cure the default within ten (10) days after the occurrence thereof; provided, however, that if the default cannot by its nature be cured within the ten (10) day period or cannot after diligent
attempts by the Credit Parties be cured within such ten (10) day period, and such default is likely to be cured within a reasonable time, then the Credit Parties shall have an additional period (which shall not in any case exceed thirty
(30) days) to attempt to cure such default, and within such reasonable time period the failure to cure the default shall not be deemed an Event of Default (but no Credit Extensions shall be made during such cure period). Cure periods provided
under this section shall not apply, among other things, to financial covenants or any other covenants set forth in clause (a) above; 

9.3. Material Adverse Change. A Material Adverse Change occurs; 

9.4. Attachment; Levy; Restraint on Business. 

(a) (i) The service of process seeking to attach, by trustee or similar process, any funds of any Credit Party or of any entity under the
control of any Credit Party (including a Subsidiary) on deposit or otherwise maintained with any Lender or any Lender’s Affiliate, or (ii) a notice of lien or levy is filed against any Credit Party’s assets by any government agency,
and the same under subclauses (i) and (ii) hereof are not, within ten (10) days after the occurrence thereof, discharged or stayed (whether through the posting of a bond or otherwise); provided, however, no Credit Extensions shall be
made during any ten (10) day cure period; or 
 (b) (i) Any material portion of any Credit Party’s assets is attached,
seized, levied on, or comes into possession of a trustee or receiver, or (ii) any court order enjoins, restrains, or prevents any Credit Party from conducting any material part of its business; 

9.5. Insolvency. (a) Any Credit Party is unable to pay its debts (including trade debts) as they become due or otherwise
becomes insolvent; (b) any Credit Party begins an Insolvency Proceeding; or (c) an Insolvency Proceeding is begun against any Credit Party and not dismissed or stayed within thirty (30) days (but no Credit

  

 -27- 

 
Extensions shall be made while of any of the conditions described in clause (a) exist and/or until any Insolvency Proceeding is dismissed); 

9.6. Other Agreements. There is: 

(a) under the Existing Kreos Loan Agreement, any default resulting in a right by Kreos Capital III (UK) Limited, whether or not exercised,
to accelerate the maturity of the Indebtedness thereunder; 
 (b) under any agreement to which a Credit Party is a party with a
third party or parties, (i) any default resulting in a right by such third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in an amount in excess of Two Hundred and Fifty Thousand Dollars ($250,000),
individually, or in excess of Five Hundred Thousand Dollars ($500,000), when aggregated with all other defaults by Credit Parties under agreements with third parties, or (ii) any default by any Credit Party, the result of which could have a
material adverse effect on such Credit Party’s business or assets; 
 9.7. Judgments. One or more final judgments,
orders, or decrees for the payment of money in an amount in excess of Two Hundred and Fifty Thousand Dollars ($250,000), individually, or in excess of Five Hundred Thousand Dollars ($500,000), when aggregated with all other final judgments, orders,
or decrees for the payment of money (but excluding any final judgments, orders, or decrees for the payment of money that are covered by independent third-party insurance as to which liability has been accepted by such insurance carrier), shall be
rendered against one or more Credit Parties and the same are not, within ten (10) days after the entry thereof, discharged or execution thereof stayed or bonded pending appeal, or such judgments are not discharged prior to the expiration of any
such stay (provided that no Credit Extensions will be made prior to the discharge, stay, or bonding of such judgment, order, or decree); 

9.8. Misrepresentations. Any Credit Party or any Person acting for any Credit Party makes any representation, warranty, or other
statement now or later in this Agreement, any Loan Document or in any writing delivered to the Administrative Agent and/or any Lender or to induce the Administrative Agent and/or any Lender to enter this Agreement or any Loan Document, and such
representation, warranty, or other statement is incorrect in any material respect when made; 
 9.9. Subordinated Debt.
Any document, instrument, or agreement evidencing any Subordinated Debt shall for any reason be revoked or in validated or otherwise cease to be in full force and effect, any Person shall be in breach thereof or contest in any manner the validity or
enforceability thereof or deny that it has any further liability or obligation thereunder, or the Obligations shall for any reason be subordinated or shall not have the priority contemplated by this Agreement; or 

9.10. Post-closing Agreement. The Credit Parties fail or neglect to perform any obligation contained in that certain letter
agreement to be entered into on the Effective Date by and among the Credit Parties and the Administrative Agent. 
 10.
RIGHTS AND REMEDIES UPON AN EVENT OF DEFAULT 
 10.1. Rights and Remedies. While an Event of Default occurs and
continues the Administrative Agent may, without notice or demand, do any or all of the following: 
 (a) declare all Obligations
immediately due and payable (but if an Event of Default described in Section 9.5 occurs all Obligations are immediately due and payable without any action by the Administrative Agent); 

(b) stop advancing money or extending credit for Borrowers’ benefit under this Agreement or under any other agreement between
Borrowers and the Administrative Agent; 
 (c) settle or adjust disputes and claims directly with Account Debtors for amounts on
terms and in any order that the Administrative Agent considers advisable, notify any Person owing Borrowers money of the Administrative Agent’s security interest in such funds, and verify the amount of such account; 

 

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 (d) make any payments and do any acts it considers necessary or reasonable to protect the
Collateral and/or its security interest in the Collateral. Borrowers shall assemble the Collateral if the Administrative Agent requests and make it available as the Administrative Agent designates. Administrative Agent may enter premises where the
Collateral is located, take and maintain possession of any part of the Collateral, and pay, purchase, contest, or compromise any Lien which appears to be prior or superior to its security interest and pay all expenses incurred. Borrowers grant
Administrative Agent a license to enter and occupy any of their premises, without charge, to exercise any of Administrative Agent’s rights or remedies; 

(e) apply to the Obligations any (i) balances and deposits of Borrowers it holds, or (ii) any amount held by Administrative
Agent owing to or for the credit or the account of Borrowers; 
 (f) ship, reclaim, recover, store, finish, maintain, repair,
prepare for sale, advertise for sale, and sell the Collateral Administrative Agent is hereby granted a non-exclusive, royalty-free license or other right to use, without charge, Borrowers’ labels, Patents, Copyrights, mask works, rights of use
of any name, trade secrets, trade names, Trademarks, and advertising matter, or any similar property as it pertains to the Collateral, in completing production of, advertising for sale, and selling any Collateral and, in connection with
Administrative Agent’s exercise of its rights under this Section, Borrowers’ rights under all licenses and all franchise agreements inure to Administrative Agent’s benefit; 

(g) place a “hold” on any account maintained with Administrative Agent and/or deliver a notice of exclusive control, any
entitlement order, or other directions or instructions pursuant to any Control Agreement or similar agreements providing control of any Collateral; 

(h) demand and receive possession of Borrowers’ Books; and 

(i) exercise all rights and remedies available to Administrative Agent and/or any Lender under the Loan Documents or at law or equity,
including all remedies provided under the Code (including disposal of the Collateral pursuant to the terms thereof). 
 10.2.
Power of Attorney. Each Borrower hereby irrevocably appoints Administrative Agent as its lawful attorney-in-fact, exercisable upon the occurrence and during the continuance of an Event of Default, to: (a) endorse Borrower’s name on any
checks or other forms of payment or security; (b) sign Borrower’s name on any invoice or bill of lading for any Account or drafts against Account Debtors; (c) settle and adjust disputes and claims about the Accounts directly with
Account Debtors, for amounts and on terms Administrative Agent determines reasonable; (d) make, settle, and adjust all claims under Borrower’s insurance policies; (e) pay, contest or settle any Lien, charge, encumbrance, security
interest, and adverse claim in or to the Collateral, or any judgment based thereon, or otherwise take any action to terminate or discharge the same; and (f) transfer the Collateral into the name of Administrative Agent or a third party as the
Code permits. Each Borrower hereby appoints Administrative Agent as its lawful attorney-in-fact to sign Borrower’s name on any documents necessary to perfect or continue the perfection of Administrative Agent’s security interest in the
Collateral regardless of whether an Event of Default has occurred until all Obligations (other than inchoate indemnity obligations) have been satisfied in full and Administrative Agent is under no further obligation to make Credit Extensions
hereunder. Administrative Agent’s foregoing appointment as each Borrower’s attorney in fact, and all of Administrative Agent’s rights and powers, coupled with an interest, are irrevocable until all Obligations (other than inchoate
indemnity obligations) have been fully repaid and performed and each Lender’s obligation to provide Credit Extensions terminates. 

10.3. Protective Payments. If Borrowers fail to obtain the insurance called for by Section 6.5 or fail to pay any
premium thereon or fail to pay any other amount which Borrowers are obligated to pay under this Agreement or any other Loan Document, Administrative Agent may obtain such insurance or make such payment, and all amounts so paid by Administrative
Agent are Lender Expenses and immediately due and payable, bearing interest at the then highest rate applicable to the Obligations, and secured by the Collateral. Administrative Agent will make reasonable efforts to provide Borrowers with notice of
Administrative Agent obtaining such insurance at the time it is obtained or within a reasonable time thereafter. No payments by Administrative Agent are deemed an agreement to make similar payments in the future or Administrative Agent’s waiver
of any Event of Default. 
 10.4. Application of Payments and Proceeds Upon Default. If an Event of Default has occurred
and is continuing, Administrative Agent may apply any funds in its possession, whether from Borrower account 
  

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balances, payments, proceeds realized as the result of any collection of Accounts or other disposition of the Collateral, or otherwise, to the Obligations in such order as Administrative Agent
shall determine in its sole discretion. Any surplus shall be paid to Borrowers or other Persons legally entitled thereto; Borrowers shall remain liable to Administrative Agent for any deficiency. If Administrative Agent, in its good faith business
judgment, directly or indirectly enters into a deferred payment or other credit transaction with any purchaser at any sale of Collateral, Administrative Agent shall have the option, exercisable at any time, of either reducing the Obligations by the
principal amount of the purchase price or deferring the reduction of the Obligations until the actual receipt by Administrative Agent of cash therefor. 

10.5. Administrative Agent’s Liability for Collateral. So long as Administrative Agent complies with reasonable banking
practices regarding the safekeeping of the Collateral in the possession or under the control of Administrative Agent, Administrative Agent shall not be liable or responsible for: (a) the safekeeping of the Collateral; (b) any loss or
damage to the Collateral; (c) any diminution in the value of the Collateral; or (d) any act or default of any carrier, warehouseman, bailee, or other Person. Borrowers bear all risk of loss, damage or destruction of the Collateral.

 10.6. No Waiver; Remedies Cumulative. Administrative Agent’s failure, at any time or times, to require strict
performance by Borrowers of any provision of this Agreement or any other Loan Document shall not waive, affect, or diminish any right of Administrative Agent thereafter to demand strict performance and compliance herewith or therewith. No waiver
hereunder shall be effective unless signed by the party granting the waiver and then is only effective for the specific instance and purpose for which it is given. Administrative Agent’s rights and remedies under this Agreement and the other
Loan Documents are cumulative. Administrative Agent has all rights and remedies provided under the Code, by law, or in equity. Administrative Agent’s exercise of one right or remedy is not an election and shall not preclude Administrative Agent
from exercising any other remedy under this Agreement or other remedy available at law or in equity, and Administrative Agent’s waiver of any Event of Default is not a continuing waiver. Administrative Agent’s delay in exercising any
remedy is not a waiver, election, or acquiescence. 
 10.7. Demand Waiver. Borrowers waive demand, notice of default or
dishonor, notice of payment and nonpayment, notice of any default, nonpayment at maturity, release, compromise, settlement, extension, or renewal of accounts, documents, instruments, chattel paper, and guarantees held by Administrative Agent on
which Borrowers are liable. 
 11. ADMINISTRATIVE AGENT  

11.1. Appointment of Administrative Agent. Kreos is hereby appointed Administrative Agent hereunder and under the other Loan
Documents and each Lender hereby authorizes Kreos to act as Administrative Agent in accordance with the terms hereof and the other Loan Documents. The Administrative Agent hereby agrees to act in its capacity as such upon the express conditions
contained herein and the other Loan Documents, as applicable. The provisions of this Section 11 are solely for the benefit of the Administrative Agent and Lenders and no Credit Party shall have any rights as a third party beneficiary of
any of the provisions thereof. Except as otherwise provided in Section 2.9(b), in performing its functions and duties hereunder, the Administrative Agent shall act solely as an agent of Lenders and does not assume and shall not be deemed
to have assumed any obligation towards or relationship of agency or trust with or for Borrowers or any of its Subsidiaries. 

11.2. Powers and Duties. Each Lender irrevocably authorizes the Administrative Agent to take such action on such Lender’s
behalf and to exercise such powers, rights and remedies hereunder and under the other Loan Documents as are specifically delegated or granted to the Administrative Agent by the terms hereof and thereof, together with such powers, rights and remedies
as are reasonably incidental thereto. The Administrative Agent shall have only those duties and responsibilities that are expressly specified herein and the other Loan Documents and no implied duties or responsibilities shall be read into this
Agreement against the Administrative Agent. The Administrative Agent may exercise such powers, rights and remedies and perform such duties by or through its agents or employees. The Administrative Agent shall not have, by reason hereof or any of the
other Loan Documents, a fiduciary relationship in respect of any Lender; and nothing herein or any of the other Loan Documents, expressed or implied, is intended to or shall be so construed as to impose upon the Administrative Agent any obligations
in respect hereof or any of the other Loan Documents except as expressly set forth herein or therein. 
  

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 11.3. General Immunity. 

(a) No Responsibility for Certain Matters. The Administrative Agent shall not be responsible to any Lender for the execution,
effectiveness, genuineness, validity, enforceability, collectability or sufficiency hereof or any other Loan Document or for any representations, warranties, recitals or statements made herein or therein or made in any written or oral statements or
in any financial or other statements, instruments, reports or certificates or any other documents furnished or made by the Administrative Agent to the Lenders or by or on behalf of any Credit Party or any Lender in connection with the Loan Documents
and the transactions contemplated thereby or for the financial condition or business affairs of any Credit Party or any other Person liable for the payment of any Obligations, nor shall the Administrative Agent be required to ascertain or inquire as
to the performance or observance of any of the terms, conditions, provisions, covenants or agreements contained in any of the Loan Documents or as to the existence or possible existence of any Event of Default or Default or to make any disclosures
with respect to the foregoing. Anything contained herein to the contrary notwithstanding, the Administrative Agent shall not have any liability arising from confirmations of the amount of outstanding Term Loans or the component amounts thereof.

 (b) Exculpatory Provisions. The Administrative Agent and any of its officers, partners, directors, employees or agents
shall not be liable to the Lenders for any action taken or omitted by the Administrative Agent under or in connection with any of the Loan Documents except to the extent caused by the Administrative Agent’s gross negligence or willful
misconduct, as determined by a final, non-appealable judgment of a court of competent jurisdiction. The Administrative Agent shall be entitled to refrain from any act or the taking of any action (including the failure to take an action) in
connection herewith or any of the other Loan Documents or from the exercise of any power, discretion or authority vested in it hereunder or thereunder unless and until the Administrative Agent shall have received instructions in respect thereof from
Requisite Lenders (or such other Lenders as may be required to give such instructions under Section 14.5) and, upon receipt of such instructions from Requisite Lenders (or such other Lenders, as the case may be), the Administrative Agent
shall be entitled to act or (where so instructed) refrain from acting, or to exercise such power, discretion or authority, in accordance with such instructions. The Administrative Agent may distribute documents, deliverables or other materials to
the Lenders for acceptance or rejection, and may, upon appropriate notice, rely on the lack of an objection by Lenders as a deemed approval of the action presented. Without prejudice to the generality of the foregoing, (i) the Administrative
Agent shall be entitled to rely, and shall be fully protected in relying, upon any communication, instrument or document believed by it to be genuine and correct and to have been signed or sent by the proper Person or Persons and shall be entitled
to rely and shall be protected in relying on opinions and judgments of attorneys (who may be attorneys for Borrowers and their Subsidiaries), accountants, experts and other professional advisors selected by it; and (ii) no Lender shall have any
right of action whatsoever against the Administrative Agent as a result of the Administrative Agent acting or (where so instructed) refraining from acting hereunder or any of the other Loan Documents in accordance with the instructions of Requisite
Lenders (or such other Lenders as may be required to give such instructions under Section 14.5). 
 (c) Delegation of
Duties. The Administrative Agent may perform any and all of its duties and exercise its rights and powers under this Agreement or under any other Loan Document by or through any one or more sub-agents appointed by the Administrative Agent. The
Administrative Agent and any such sub-agent may perform any and all of its duties and exercise its rights and powers by or through their respective Affiliates. The exculpatory, indemnification and other provisions of this Section 11.3
and of Section 11.6 shall apply to any of the Affiliates of the Agents, and shall apply to their respective activities as Administrative Agent. All of the rights, benefits, and privileges (including the exculpatory and indemnification
provisions) of this Section 11.3 and of Section 11.6 shall apply to any such sub-agent and to the Affiliates of any such sub-agent, and shall apply to their respective activities as sub-agent as if such sub-agent and
Affiliates were named herein. Notwithstanding anything herein to the contrary, with respect to each sub-agent appointed by the Administrative Agent, (i) such sub-agent shall be a third party beneficiary under this Agreement with respect to all
such rights, benefits and privileges (including exculpatory rights and rights to indemnification) and shall have all of the rights and benefits of a third party beneficiary, including an independent right of action to enforce such rights, benefits
and privileges (including exculpatory rights and rights to indemnification) directly, without the consent or joinder of any other Person, against any or all of the Credit Parties and the Lenders, (ii) such rights, benefits and privileges
(including exculpatory rights and rights to indemnification) shall not be modified or amended without the consent of such sub-agent, and (iii) such sub-agent shall only have obligations to the Administrative Agent, and not to any Credit Party,
Lender or any other 
  

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Person and no Credit Party, Lender or any other Person shall have any rights, directly or indirectly, as a third party beneficiary or otherwise, against such sub-agent. 

11.4. Administrative Agent Entitled to Act as Lender. The agency hereby created shall in no way impair or affect any of the rights
and powers of, or impose any duties or obligations upon, the Administrative Agent in its individual capacity as a Lender hereunder. With respect to its participation in the Term Loans, the Administrative Agent shall have the same rights and powers
hereunder as any other Lender and may exercise the same as if it were not performing the duties and functions delegated to it hereunder, and the term “Lender” shall, unless the context clearly otherwise indicates, include the
Administrative Agent in its individual capacity. The Administrative Agent and its respective Affiliates may accept deposits from, lend money to, own securities of, and generally engage in any kind of banking, trust, financial advisory or other
business with Borrowers or any of their Affiliates as if it were not performing the duties specified herein, and may accept fees and other consideration from Borrowers for services in connection herewith and otherwise without having to account for
the same to Lenders. 
 11.5. Lenders’ Representations, Warranties and Acknowledgment. 

(a) Each Lender represents and warrants that it has made its own independent investigation of the financial condition and affairs of
Borrowers and their Subsidiaries in connection with Credit Extensions hereunder and that it has made and shall continue to make its own appraisal of the creditworthiness of Borrowers and their Subsidiaries. The Administrative Agent shall not have
any duty or responsibility, either initially or on a continuing basis, to make any such investigation or any such appraisal on behalf of Lenders or to provide any Lender with any credit or other information with respect thereto, whether coming into
its possession before the making of the Term Loans or at any time or times thereafter, and the Administrative Agent shall not have any responsibility with respect to the accuracy of or the completeness of any information provided to Lenders.

 (b) Each Lender on the Effective Date shall be deemed to have acknowledged receipt of, and consented to and approved, each
Loan Document and each other document required to be approved by the Administrative Agent, Requisite Lenders or Lenders, as applicable on the Effective Date. 

11.6. Right to Indemnity. Each Lender, in proportion to its Pro Rata Share, severally agrees to indemnify the Administrative
Agent, to the extent that the Administrative Agent shall not have been reimbursed by any Credit Party, for and against any and all liabilities, obligations, losses, damages, penalties, actions, judgments, suits, costs, expenses (including counsel
fees and disbursements) or disbursements of any kind or nature whatsoever which may be imposed on, incurred by or asserted against the Administrative Agent in exercising its powers, rights and remedies or performing its duties hereunder or under the
other Loan Documents or otherwise in its capacity as the Administrative Agent in any way relating to or arising out of this Agreement or the other Loan Documents; provided, no Lender shall be liable for any portion of such liabilities, obligations,
losses, damages, penalties, actions, judgments, suits, costs, expenses or disbursements resulting from the Administrative Agent’s gross negligence or willful misconduct, as determined by a final, non-appealable judgment of a court of competent
jurisdiction. If any indemnity furnished to the Administrative Agent for any purpose shall, in the opinion of the Administrative Agent, be insufficient or become impaired, the Administrative Agent may call for additional indemnity and cease, or not
commence, to do the acts indemnified against until such additional indemnity is furnished; provided, in no event shall this sentence require any Lender to indemnify the Administrative Agent against any liability, obligation, loss, damage, penalty,
action, judgment, suit, cost, expense or disbursement in excess of such Lender’s Pro Rata Share thereof; and provided further, this sentence shall not be deemed to require any Lender to indemnify the Administrative Agent against any liability,
obligation, loss, damage, penalty, action, judgment, suit, cost, expense or disbursement described in the proviso in the immediately preceding sentence. 

11.7. Successor Administrative Agent. The Administrative Agent may resign at any time by giving thirty days’ prior written
notice thereof to Lenders and Borrowers, and the Administrative Agent may be removed at any time with or without cause by an instrument or concurrent instruments in writing delivered to Borrowers and the Administrative Agent and signed by Requisite
Lenders. Upon any such notice of resignation or any such removal, Requisite Lenders shall have the right, upon five Business Days’ notice to Borrowers, to appoint a successor Administrative Agent. Upon the acceptance of any appointment as
Administrative Agent hereunder by a successor Administrative Agent, that successor Administrative Agent shall thereupon succeed to and become vested with all the rights, powers, privileges and duties of the resigning or removed Administrative Agent
and the resigning or removed Administrative Agent shall promptly transfer to such successor Administrative Agent all sums, together 

 

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with all records and other documents necessary or appropriate in connection with the performance of the duties of the successor Administrative Agent under the Loan Documents. If the Requisite
Lenders have not appointed a successor Administrative Agent, the Administrative Agent shall have the right to appoint a financial institution to act as Administrative Agent hereunder and in any case, the Administrative Agent’s resignation shall
become effective on the thirtieth day after such notice of resignation. If neither the Requisite Lenders nor the Administrative Agent have appointed a successor Administrative Agent, the Requisite Lenders shall be deemed to succeeded to and become
vested with all the rights, powers, privileges and duties of the resigning Administrative Agent. After any resigning or removed Administrative Agent’s resignation or removal hereunder as Administrative Agent, the provisions of this
Section 11 shall inure to its benefit as to any actions taken or omitted to be taken by it while it was Administrative Agent hereunder. 

11.8. Collateral Documents and Guaranty. 

(a) Agent under Collateral Documents and Guaranty. Each Lender hereby further authorizes the Administrative Agent, on behalf of and
for the benefit of Lenders, to be the agent for and representative of the Lenders with respect to the Guaranty, the Collateral and the Collateral Documents. Subject to Section 14.5, without further written consent or authorization from
any Lenders, the Administrative Agent shall, at the request and expense of Credit Parties, execute any documents or instruments necessary to, (i) in connection with a sale or disposition of assets permitted by this Agreement, release any Lien
encumbering any item of Collateral that is the subject of such sale or other disposition of assets or to which Requisite Lenders (or such other Lenders as may be required to give such consent under Section 14.5) have otherwise consented
or (ii) release Guarantor from the Guaranty pursuant to Section 8.11 or with respect to which Requisite Lenders (or such other Lenders as may be required to give such consent under Section 14.5) have otherwise consented.

 (b) Right to Realize on Collateral and Enforce Guaranty. Anything contained in any of the Loan Documents to the
contrary notwithstanding, each Credit Party, the Administrative Agent and each Lender hereby agree that (i) no Lender shall have any right individually to realize upon any of the Collateral or to enforce the Guaranty, it being understood and
agreed that all powers, rights and remedies hereunder may be exercised solely by the Administrative Agent, on behalf of the Lenders in accordance with the terms hereof and all powers, rights and remedies under the Collateral Documents may be
exercised solely by the Administrative Agent, and (ii) in the event of a foreclosure by the Administrative Agent on any of the Collateral pursuant to a public or private sale or other disposition, the Administrative Agent or any Lender may be
the purchaser or licensor of any or all of such Collateral at any such sale or other disposition and the Administrative Agent, as agent for and representative of the Lenders (but not any Lender or Lenders in its or their respective individual
capacities unless Requisite Lenders shall otherwise agree in writing) shall be entitled, for the purpose of bidding and making settlement or payment of the purchase price for all or any portion of the Collateral sold at any such public sale, to use
and apply any of the Obligations as a credit on account of the purchase price for any collateral payable by the Administrative Agent at such sale or other disposition. 

11.9. Withholding Taxes. 

To the extent required by any applicable law, the Administrative Agent may withhold from any payment to any Lender an amount equivalent to
any applicable withholding Tax. If the Internal Revenue Service or any other Governmental Authority asserts a claim that the Administrative Agent did not properly withhold Tax from amounts paid to or for the account of any Lender because the
appropriate form was not delivered or was not properly executed or because such Lender failed to notify the Administrative Agent of a change in circumstance which rendered the exemption from, or reduction of, withholding Tax ineffective or for any
other reason, such Lender shall indemnify the Administrative Agent fully for all amounts paid, directly or indirectly, by the Administrative Agent as Tax or otherwise, including any penalties or interest and together with all expenses (including
legal expenses, allocated internal costs and out-of-pocket expenses) incurred. 
 12. NOTICES 

All notices, consents, requests, approvals, demands, or other communication by any party to this Agreement or any other Loan Document must
be in writing and shall be deemed to have been validly served, given, or delivered: (a) upon the earlier of actual receipt and three (3) Business Days after deposit in the U.S. mail, first

  

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class, registered or certified mail return receipt requested, with proper postage prepaid; (b) upon transmission, when sent by electronic mail or facsimile transmission; (c) one
(1) Business Day after deposit with a reputable overnight courier with all charges prepaid; or (d) when delivered, if hand-delivered by messenger, all of which shall be addressed to the party to be notified and sent to the address,
facsimile number, or email address indicated below or, in the case of a Lender, the address, facsimile number or email address set forth on such Lender’s signature page hereto. Any Lender or Credit Party may change its mailing or electronic
mail address or facsimile number by giving all other parties hereto written notice thereof in accordance with the terms of this Section 12. 
  

			
	If to Horizon:	    	 Horizon Pharma USA, Inc.
 1033
Skokie Boulevard, Suite 355
 Northbrook, Illinois 60062

Attn: Timothy P. Walbert
 Fax: (847) 572-1372

 Email: twalbert@horizontherapeutics.com

		
	with a copy to:	    	 Cooley Godward Kronish LLP

4401 Eastgate Mall
 San Diego, California 92121

 Attn: Barbara Borden, Esq. and Kay Chandler, Esq.

Fax: (858) 550-6420
 Email: bordenbl@cooley.com
and kchandler@cooley.com

		
	If to Nitec:	    	 Nitec Pharma AG
 Kagenstrasse
17
 CH-4153 Reinach

Switzerland
 Attn: Timothy P. Walbert

Fax: (847) 572-1372
 Email:
twalbert@horizontherapeutics.com

		
	with a copy to:	    	 Cooley Godward Kronish LLP

4401 Eastgate Mall
 San Diego, California 92121

 Attn: Barbara Borden, Esq. and Kay Chandler, Esq.

Fax: (858) 550-6420
 Email: bordenbl@cooley.com
and kchandler@cooley.com

		
	If to Guarantor:	    	 Horizon Pharma, Inc.
 1033
Skokie Boulevard, Suite 355
 Northbrook, Illinois 60062

Attn: Timothy P. Walbert
 Fax: (847) 572-1372

 Email: twalbert@horizontherapeutics.com

		
	with a copy to:	    	 Cooley Godward Kronish LLP

4401 Eastgate Mall
 San Diego, California 92121

 Attn: Barbara Borden, Esq. and Kay Chandler, Esq.

Fax: (858) 550-6420
 Email: bordenbl@cooley.com
and kchandler@cooley.com

		
	If to the Administrative Agent:	    	  
 Kreos Capital III (UK) Limited

25-28 Old Burlington Street
 London W1S
3AN
 Attn: Donatella Callegaris

  

 -34- 

			
		    	 Fax: +44 (0)20-7409-1034

Email: donatella@kreoscapital.co.uk

		
	with copies to:	    	 Speechly Bircham LLP
 6 New
Street Square
 London EC4A 3LX
 United
Kingdom
 Attn: James Watts, Esq.
 Fax:
+44 (0)20-7427-6600
 Email: James.Watts@speechlys.com

		
	and:	    	 Sonnenschein Nath & Rosenthal LLP

2 World Financial Center
 New York, New York
10281
 Attn: Denise M. Tormey, Esq.

Fax: (212) 768-6800
 Email:
DTormey@sonnenschein.com

		
	and:	    	 Silicon Valley Bank
 230 West
Monroe Street, Suite 720
 Chicago, Illinois 60606

Attn: Kristen Parsons
 Fax: (312)
704-9512
 Email: kparsons@svb.com

		
	and:	    	 Riemer & Braunstein LLP

Three Center Plaza
 Boston, Massachusetts 02108

 Attn: David A. Ephraim, Esq.
 Fax:
(617) 880-3456
 Email: DEphraim@riemerlaw.com

13. CHOICE OF LAW, VENUE, AND JURY TRIAL WAIVER 

California law governs the Loan Documents without regard to principles of conflicts of law. Credit Parties, the Administrative Agent and
Lenders each submit to the exclusive jurisdiction of the State and Federal courts in Santa Clara County, California; provided, however, that nothing in this Agreement shall be deemed to operate to preclude the Administrative Agent from bringing suit
or taking other legal action in any other jurisdiction to realize on the Collateral or any other security for the Obligations, or to enforce a judgment or other court order in favor of the Administrative Agent, for the ratable benefit if the
Lenders. Each Credit Party expressly submits and consents in advance to such jurisdiction in any action or suit commenced in any such court, and each Credit Party hereby waives any objection that it may have based upon lack of personal jurisdiction,
improper venue, or forum non conveniens and hereby consents to the granting of such legal or equitable relief as is deemed appropriate by such court. Each Credit Party hereby waives personal service of the summons, complaints, and other process
issued in such action or suit and agrees that service of such summons, complaints, and other process may be made by registered or certified mail addressed to such Credit Party at the address set forth in Section 12 of this Agreement and
that service so made shall be deemed completed upon the earlier to occur of such Credit Party’s actual receipt thereof or three (3) days after deposit in the U.S. mails, proper postage prepaid. 

TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, CREDIT PARTIES, THE ADMINISTRATIVE AGENT, AND THE LENDERS EACH WAIVE THEIR RIGHT TO
A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION ARISING OUT OF OR BASED UPON THIS AGREEMENT, THE LOAN DOCUMENTS OR ANY CONTEMPLATED TRANSACTION, INCLUDING CONTRACT, TORT, BREACH OF DUTY AND ALL OTHER CLAIMS. THIS WAIVER IS A MATERIAL INDUCEMENT FOR
BOTH PARTIES TO ENTER INTO THIS AGREEMENT. EACH PARTY HAS REVIEWED THIS WAIVER WITH ITS COUNSEL. 
  

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 WITHOUT INTENDING IN ANY WAY TO LIMIT THE PARTIES’ AGREEMENT TO WAIVE THEIR RESPECTIVE
RIGHT TO A TRIAL BY JURY, if the above waiver of the right to a trial by jury is not enforceable, the parties hereto agree that any and all disputes or controversies of any nature between them arising at any time shall be decided by a reference to a
private judge, mutually selected by the parties (or, if they cannot agree, by the Presiding Judge of Santa Clara County, California Superior Court) appointed in accordance with California Code of Civil Procedure Section 638 (or pursuant to
comparable provisions of federal law if the dispute falls within the exclusive jurisdiction of the federal courts), sitting without a jury, in Santa Clara County, California; and the parties hereby submit to the jurisdiction of such court. The
reference proceedings shall be conducted pursuant to and in accordance with the provisions of California Code of Civil Procedure §§ 638 through 645.1, inclusive. The private judge shall have the power, among others, to grant provisional
relief, including without limitation, entering temporary restraining orders, issuing preliminary and permanent injunctions and appointing receivers. All such proceedings shall be closed to the public and confidential and all records relating thereto
shall be permanently sealed. If during the course of any dispute, a party desires to seek provisional relief, but a judge has not been appointed at that point pursuant to the judicial reference procedures, then such party may apply to the Santa
Clara County, California Superior Court for such relief. The proceeding before the private judge shall be conducted in the same manner as it would be before a court under the rules of evidence applicable to judicial proceedings. The parties shall be
entitled to discovery which shall be conducted in the same manner as it would be before a court under the rules of discovery applicable to judicial proceedings. The private judge shall oversee discovery and may enforce all discovery rules and orders
applicable to judicial proceedings in the same manner as a trial court judge. The parties agree that the selected or appointed private judge shall have the power to decide all issues in the action or proceeding, whether of fact or of law, and shall
report a statement of decision thereon pursuant to California Code of Civil Procedure § 644(a). Nothing in this paragraph shall limit the right of any party at any time to exercise self-help remedies, foreclose against collateral, or obtain
provisional remedies. The private judge shall also determine all issues relating to the applicability, interpretation, and enforceability of this paragraph. 

14. GENERAL PROVISIONS 

14.1. Successors and Assigns; Participations. 

(a) Generally. This Agreement shall be binding upon the parties hereto and their respective successors and assigns and shall inure
to the benefit of the parties hereto and the successors and assigns of Lenders. No Credit Party’s rights or obligations hereunder nor any interest therein may be assigned or delegated by any Credit Party without the prior written consent of all
Lenders. Nothing in this Agreement, expressed or implied, shall be construed to confer upon any Person (other than the parties hereto, their respective successors and assigns permitted hereby and, to the extent expressly contemplated hereby,
Affiliates of each of the Administrative Agent and Lenders) any legal or equitable right, remedy or claim under or by reason of this Agreement. 

(b) Register. Credit Parties, the Administrative Agent and Lenders shall deem and treat the Persons listed as Lenders in the
Register as the holders and owners of the corresponding Term Commitments, and Term Loans listed therein for all purposes hereof, and no assignment or transfer of any such Term Commitment or Term Loan shall be effective, in each case, unless and
until recorded in the Register following receipt of an Assignment Agreement effecting the assignment or transfer thereof, in each case, as provided in Section 14.1(d). Each assignment shall be recorded in the Register on the Business Day
the Assignment Agreement is received by Administrative Agent, if received by 12:00 noon New York City time, and on the following Business Day if received after such time, prompt notice thereof shall be provided to the Credit Parties and a copy of
such Assignment Agreement shall be maintained, as applicable. The date of such recordation of a transfer shall be referred to herein as the “Assignment Effective Date.” Any request, authority or consent of any Person who, at the
time of making such request or giving such authority or consent, is listed in the Register as a Lender shall be conclusive and binding on any subsequent holder, assignee or transferee of the corresponding Term Commitments or Term Loans. 

(c) Right to Assign. Each Lender shall have the right at any time to sell, assign or transfer all or a portion of its rights and
obligations under this Agreement, including all or a portion of its Term Commitment or Term Loans owing to it or other Obligations (provided, however, that pro rata assignments shall not be required and each assignment shall be of a uniform, and not
varying, percentage of all rights and obligations under and in respect of any applicable Term Loan and any related Term Commitments): 
  

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 (i) to any Qualifying Lender meeting the criteria of clause (i) of the definition of
the term of “Eligible Assignee” upon the giving of notice to Credit Parties and the Administrative Agent; or 
 (ii)
to any Qualifying Lender meeting the criteria of clause (ii) of the definition of the term of “Eligible Assignee” upon giving of notice to Credit Parties and the Administrative Agent and, in the case of assignments of Term Loans or
Term Commitments to any such Person (except in the case of assignments made by or to the Administrative Agent), consented to by each of Credit Parties and the Administrative Agent (such consent not to be (x) unreasonably withheld or delayed or,
(y) in the case of Credit Parties, required at any time an Event of Default shall have occurred and then be continuing); provided, further each such assignment pursuant to this Section 14.1(c)(ii) shall be in an aggregate amount of
not less than Five Hundred Thousand Dollars ($500,000). 
 (d) Mechanics. Assignments and assumptions of Term Loans, and
Term Commitments shall only be effected by manual execution and delivery to the Administrative Agent of an Assignment Agreement. Assignments shall be effective as of the Assignment Effective Date. In connection with all assignments there shall be
delivered to the Administrative Agent such forms, certificates or other evidence, if any, with respect to United States backup withholding and federal income Tax withholding matters as the assignee under such Assignment Agreement may be required to
deliver pursuant to Section 2.7(c). 
 (e) Representations and Warranties of Assignee. Each Lender, upon execution
and delivery hereof or upon succeeding to an interest in the Term Commitments and Term Loans, as the case may be, represents and warrants as of the Effective Date or as of the Assignment Effective Date that (i) it is an Eligible Assignee;
(ii) it has experience and expertise in the making of or investing in commitments or loans such as the applicable Term Commitments or Term Loans, as the case may be; and (iii) it will make or invest in, as the case may be, its Term
Commitments or Term Loans for its own account in the ordinary course and without a view to distribution of such Term Commitments or Term Loans within the meaning of the Securities Act or the Exchange Act or other federal securities laws (it being
understood that, subject to the provisions of this Section 14.1, the disposition of such Term Commitments or Term Loans or any interests therein shall at all times remain within its exclusive control). 

(f) Effect of Assignment. Subject to the terms and conditions of this Section 14.1 as of the Assignment Effective Date
with respect to any Assignment Agreement (i) the assignee thereunder shall have the rights and obligations of a “Lender” hereunder to the extent of its interest in the Term Loans and Term Commitments as reflected in the Register and
shall thereafter be a party hereto and a “Lender” for all purposes hereof; (ii) the assigning Lender thereunder shall, to the extent that rights and obligations hereunder have been assigned to the assignee, relinquish its rights
(other than any rights which survive the termination hereof under Section 14.7) and be released from its obligations hereunder (and, in the case of an assignment covering all or the remaining portion of an assigning Lender’s rights
and obligations hereunder, such Lender shall cease to be a party hereto on the Assignment Effective Date; provided, anything contained in any of the Loan Documents to the contrary notwithstanding, such assigning Lender shall continue to be entitled
to the benefit of all indemnities hereunder as specified herein with respect to matters arising out of the prior involvement of such assigning Lender as a Lender hereunder); (iii) the Term Commitments shall be modified to reflect any Term
Commitment of such assignee and any Term Commitment of such assigning Lender, if any; and (iv) if any such assignment occurs after the issuance of any Term Loan Note hereunder, the assigning Lender shall, upon the effectiveness of such
assignment or as promptly thereafter as practicable, surrender its applicable Term Loan Notes to the Administrative Agent for cancellation, and thereupon Borrowers shall issue and deliver new Term Loan Notes, if so requested by the assignee and/or
assigning Lender, to such assignee and/or to such assigning Lender, with appropriate insertions, to reflect the new Term Commitments and/or outstanding Term Loans of the assignee and/or the assigning Lender. 

(g) Participations. 

(i) Each Lender shall have the right at any time to sell one or more participations to any Qualifying Lender (other than Credit Parties,
any of their Subsidiaries or any of their Affiliates) in all or any part of its Term Commitments, Term Loans or in any other Obligation. Further sub-participations are excluded. 

(ii) The holder of any such participation, other than an Affiliate of the Lender granting such participation, shall not be entitled to
require such Lender to take or omit to take any action 
  

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hereunder except with respect to any amendment, modification or waiver that would (A) extend the final scheduled maturity of any Term Loan or Term Loan Note in which such participant is
participating, or reduce the rate or extend the time of payment of interest or fees thereon (except in connection with a waiver of applicability of any post default increase in interest rates) or reduce the principal amount thereof, or increase the
amount of the participant’s participation over the amount thereof then in effect (it being understood that a waiver of any Default or Event of Default or of a mandatory reduction in the Term Commitment shall not constitute a change in the terms
of such participation, and that an increase in any Term Commitment or Term Loan shall be permitted without the consent of any participant if the participant’s participation is not increased as a result thereof), (B) consent to the
assignment or transfer by any Credit Party of any of its rights and obligations under this Agreement or (C) release all or substantially all of the Collateral under the Collateral Documents (except as expressly provided in the Loan Documents)
supporting the Term Loans hereunder in which such participant is participating. 
 (iii) Each Credit Party agrees that each
participant shall be entitled to the benefits of Sections 2.6 and 2.7 to the same extent as if it were a Lender and had acquired its interest by assignment pursuant to paragraph (c) of this Section; provided, (x) a
participant shall not be entitled to receive any greater payment under Sections 2.6 and 2.7 than the applicable Lender would have been entitled to receive with respect to the participation sold to such participant, unless the sale of
the participation to such participant is made with Credit Parties’ prior written consent and (y) a participant that would be a Non U.S. Lender if it were a Lender shall not be entitled to the benefits of Section 2.7 unless
Credit Parties are notified of the participation sold to such participant and such participant agrees, for the benefit of Credit Parties, to comply with Section 2.7 as though it were a Lender; provided further that, except as
specifically set forth in clauses (x) and (y) of this sentence, nothing herein shall require any notice to Credit Parties or any other Person in connection with the sale of any participation. To the extent permitted by law, each
participant also shall be entitled to the benefits of Section 14.10 as though it were a Lender, provided such participant agrees to be subject to Section 2.2(h) as though it were a Lender. 

(h) Certain Other Assignments and Participations. In addition to any other assignment or participation permitted pursuant to this
Section 14.1: 
 (i) any Lender may assign and/or pledge all or any portion of its Term Loans, the other Obligations owed
by or to such Lender, and its Term Loan Notes, if any, to a Qualifying Lender to secure obligations of such Lender including any Federal Reserve Bank as collateral security pursuant to Regulation A of the Board of Governors and any operating
circular issued by such Federal Reserve Bank; and 
 (ii) notwithstanding anything to the contrary in this
Section 14.1, any Lender may sell participations (or otherwise transfer its rights) in or to all or a portion of its rights and obligations under the Loan Documents (including all its rights and obligations with respect to the Term
Loans) to one or more Qualifying Lenders that provide financing to such Lender; 
 provided, that no Lender, as
between Borrower and such Lender, shall be relieved of any of its obligations hereunder as a result of any such assignment, pledge, participation or other transfer and provided further, that in no event shall the applicable Federal Reserve Bank,
pledge, trustee, lender or other financing source described in the preceding clauses (i) or (ii) be considered to be a “Lender” or be entitled to require the assigning, selling or transferring Lender to take or omit to take any
action hereunder. Further assignments and participations are excluded. 
 14.2. Indemnification. 

(a) Each Credit Party agrees to indemnify, defend, pay and hold harmless the Administrative Agent, each Lender and the directors,
officers, employees, agents, attorneys, or any other Person affiliated with or representing the Administrative Agent and each Lender (each, an “Indemnified Person”) from and against any and all Indemnified Liabilities; provided,
(i) no Credit Party shall have any obligation to any Indemnified Person hereunder with respect to any Indemnified Liabilities to the extent such Indemnified Liabilities arise from the gross negligence or willful misconduct of that Indemnified
Person, in each case, as determined by a final, non-appealable judgment of a court of competent jurisdiction, and (ii) no Credit Party shall be liable for any settlement of any claim 

 

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or proceeding effected by any Indemnified Person without the prior written consent of such Credit Party (which consent shall not be unreasonably withheld or delayed), but if settled with such
consent or if there shall be a final judgment against an Indemnified Person, each of the Credit Parties shall indemnify and hold harmless such Indemnified Person from and against any loss or liability by reason of such settlement or judgment in the
manner set forth in this Agreement. 
 (b) To the extent permitted by applicable law, no Credit Party shall assert, and each
Credit Party hereby waives, any claim against each Lender, the Administrative Agent and their respective Affiliates, directors, employees, attorneys, agents or sub-agents, on any theory of liability, for special, indirect, consequential or punitive
damages (as opposed to direct or actual damages) (whether or not the claim therefor is based on contract, tort or duty imposed by any applicable legal requirement) arising out of, in connection with, arising out of, as a result of, or in any way
related to, this Agreement or any Loan Document or any agreement or instrument contemplated hereby or thereby or referred to herein or therein, the transactions contemplated hereby or thereby, any Term Loan or the use of the proceeds thereof or any
act or omission or event occurring in connection therewith, and each Credit Party hereby waives, releases and agrees not to sue upon any such claim or any such damages, whether or not accrued and whether or not known or suspected to exist in its
favor. 
 14.3. Severability of Provisions. In case any provision in or obligation hereunder or under any other Loan
Document shall be invalid, illegal or unenforceable in any jurisdiction, the validity, legality and enforceability of the remaining provisions or obligations, or of such provision or obligation in any other jurisdiction, shall not in any way be
affected or impaired thereby. 
 14.4. Correction of Loan Documents. The Administrative Agent may correct patent errors
and fill in any blanks in the Loan Documents consistent with the agreement of the parties so long as the Administrative Agent provides Credit Parties with written notice of such correction and allows Credit Parties at least ten (10) days to
object to such correction. In the event of such objection, such correction shall not be made except by an amendment signed by the Administrative Agent, Requisite Lenders and Credit Parties. 

14.5. Amendments and Waivers. 

(a) Requisite Lenders’ Consent. Subject to the additional requirements of Sections 14.5(b) and 14.5(c), no
amendment, modification, termination or waiver of any provision of the Loan Documents, or consent to any departure by any Credit Party therefrom, shall in any event be effective without the written concurrence of the Requisite Lenders; provided that
the Administrative Agent may, with the consent of Credit Parties only, amend, modify or supplement this Agreement to cure any ambiguity, omission, defect or inconsistency, so long as such amendment, modification or supplement does not adversely
affect the rights of any Lender. 
 (b) Affected Lenders’ Consent. Without the written consent of each Lender (other
than a Defaulting Lender) that would be affected thereby, no amendment, modification, termination, or consent shall be effective if the effect thereof would: 

(i) extend the scheduled final maturity of any Term Loan or Term Loan Note; 

(ii) waive, reduce or extend any scheduled repayment (but not prepayment); 

(iii) reduce the rate of interest on any Term Loan or any fee or any premium payable hereunder; 

(iv) extend the time for payment of any such interest or fees; 

(v) reduce the principal amount of any Term Loan; 

(vi) amend, modify, terminate or waive any provision of this Section 14.5(b), Section 14.5(c) or any other provision of
this Agreement that expressly provides that the consent of all Lenders is required; 
 (vii) amend the definition of
“Requisite Lenders” or “Pro Rata Share”;  
  

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 (viii) release all or substantially all of the Collateral or the Guarantor from the Guaranty
except as expressly provided in the Loan Documents; or 
 (ix) consent to the assignment or transfer by any Credit Party of any
of its rights and obligations under any Loan Document. 
 (c) Other Consents. No amendment, modification, termination or
waiver of any provision of the Loan Documents, or consent to any departure by any Credit Party therefrom, shall: 
 (i) increase
any Term Commitment of any Lender over the amount thereof then in effect without the written consent of such Lender; provided, no amendment, modification or waiver of any condition precedent, covenant, Default or Event of Default shall constitute an
increase in any Term Commitment of any Lender; 
 (ii) amend, modify or waive this Agreement so as to alter the ratable
treatment of Obligations arising under the Loan Documents; or 
 (iii) amend, modify, terminate or waive any provision of
Section 11 as the same applies to the Administrative Agent, or any other provision hereof as the same applies to the rights or obligations of the Administrative Agent, in each case without the written consent of the Administrative Agent.

 (d) Execution of Amendments, etc. The Administrative Agent may, but shall have no obligation to, with the concurrence
of any Lender, execute amendments, modifications, waivers or consents on behalf of such Lender. Any waiver or consent shall be effective only in the specific instance and for the specific purpose for which it was given. No notice to or demand on any
Credit Party in any case shall entitle any Credit Party to any other or further notice or demand in similar or other circumstances. Any amendment, modification, termination, waiver or consent effected in accordance with this Section 14.5
shall be binding upon each Lender at the time outstanding, each future Lender and, if signed by a Credit Party, on such Credit Party. 

14.6. Counterparts. This Agreement may be executed in any number of counterparts and by different parties on separate
counterparts, each of which, when executed and delivered, is an original, and all taken together, constitute one Agreement. 

14.7. Survival. All covenants, representations and warranties made in this Agreement continue in full force until this Agreement
has terminated pursuant to its terms and all Obligations (other than inchoate indemnity obligations and any other obligations which, by their terms, are to survive the termination of this Agreement) have been paid in full and satisfied. The
obligation of Credit Parties in Section 14.2 to indemnify the Administrative Agent and the Lenders shall survive until the statute of limitations with respect to such claim or cause of action shall have run. 

14.8. Confidentiality. In handling any non-public information regarding Credit Parties and their Subsidiaries and their businesses
which would reasonably be expected to be confidential, the Administrative Agent and each Lender shall exercise the same degree of care that it exercises for its own proprietary information, but disclosure of information may be made: (a) to any
Lender’s Subsidiaries or Affiliates; (b) to prospective transferees or purchasers of any interest in the Credit Extensions (provided, however, each Lender shall use its best efforts to obtain any of its prospective transferee’s or
purchaser’s agreement to the terms of this provision); (c) as required by law, regulation, subpoena, or other order; (d) to any Lender’s regulators or as otherwise required in connection with such Lender’s examination or
audit; (e) as the Administrative Agent considers appropriate in exercising remedies under the Loan Documents; and (f) to third-party service providers of the Administrative Agent or any Lender so long as such service providers have
executed a confidentiality agreement with the Administrative Agent or Lender, as applicable, with terms no less restrictive than those contained herein. Confidential information does not include information that is either: (i) in the public
domain or in the Administrative Agent’s or in any Lender’s possession when disclosed to the Administrative Agent or to any Lender, or becomes part of the public domain after disclosure to the Administrative Agent or any Lender other than
as a result of a breach by the Administrative Agent or a Lender of the obligations under this Section 14.8; or (ii) disclosed to the Administrative Agent or any Lender by a third

  

 -40- 

 
party if the Administrative Agent or such Lender does not know that the third party is prohibited from disclosing the information. 

Lenders may use confidential information for the development of databases, reporting purposes, and market analysis so long as such
confidential information is aggregated and anonymized prior to distribution unless otherwise expressly permitted by Credit Parties. The provisions of the immediately preceding sentence shall survive the termination of this Agreement. 

14.9. Attorneys’ Fees, Costs and Expenses. In any action or proceeding between any Credit Party and Administrative Agent
and/or any Lender arising out of or relating to the Loan Documents, the prevailing party shall be entitled to recover its reasonable attorneys’ fees and other costs and expenses incurred, in addition to any other relief to which it may be
entitled. 
 14.10. Right of Set-Off. In addition to any rights now or hereafter granted under applicable law and not by
way of limitation of any such rights, upon the occurrence of an Event of Default and at any time thereafter during the continuance of any Event of Default, each Lender is hereby authorized by each Credit Party at any time or from time to time
subject to the consent of the Administrative Agent (such consent not to be unreasonably withheld or delayed), without notice to any Credit Party or to any other Person (other than the Administrative Agent), any such notice being hereby expressly
waived, to set off and to appropriate and to apply any and all deposits (general or special, including Indebtedness evidenced by certificates of deposit, whether matured or unmatured, but not including trust accounts) and any other Indebtedness at
any time held or owing by such Lender to or for the credit or the account of any Credit Party against and on account of the obligations and liabilities of any Credit Party to such Lender hereunder and under the other Loan Documents, including all
claims of any nature or description arising out of or connected hereto or with any other Loan Document, irrespective of whether or not (a) such Lender shall have made any demand hereunder or (b) the principal of or the interest on the Term
Loans or any other amounts due hereunder shall have become due and payable pursuant to Section 2 and although such obligations and liabilities, or any of them, may be contingent or unmatured. 

14.11. Marshalling; Payments Set Aside. Neither the Administrative Agent nor any Lender shall be under any obligation to marshal
any assets in favor of any Credit Party or any other Person or against or in payment of any or all of the Obligations. To the extent that any Credit Party makes a payment or payments to the Administrative Agent or Lenders (or to the Administrative
Agent, on behalf of Lenders), or the Administrative Agent or Lenders enforce any Liens or exercise their rights of setoff, and such payment or payments or the proceeds of such enforcement or setoff or any part thereof are subsequently invalidated,
declared to be fraudulent or preferential, set aside and/or required to be repaid to a trustee, receiver or any other party under any bankruptcy law, any other state or federal law, common law or any equitable cause, then, to the extent of such
recovery, the obligation or part thereof originally intended to be satisfied, and all Liens, rights and remedies therefor or related thereto, shall be revived and continued in full force and effect as if such payment or payments had not been made or
such enforcement or setoff had not occurred. 
 14.12. Obligations Several; Independent Nature of Lenders’ Rights.
The obligations of Lenders hereunder are several and no Lender shall be responsible for the obligations or Term Commitment of any other Lender hereunder. Nothing contained herein or in any other Loan Document, and no action taken by Lenders
pursuant hereto or thereto, shall be deemed to constitute Lenders as a partnership, an association, a joint venture or any other kind of entity. The amounts payable at any time hereunder to each Lender shall be a separate and independent debt, and
each Lender shall be entitled to protect and enforce its rights arising out hereof and it shall not be necessary for any other Lender to be joined as an additional party in any proceeding for such purpose. 

14.13. Electronic Execution of Documents. The words “execution,” “signed,” “signature” and words of
like import in any Loan Document shall be deemed to include electronic signatures or the keeping of records in electronic form, each of which shall be of the same legal effect, validity and enforceability as a manually executed signature or the use
of a paper-based recordkeeping systems, as the case may be, to the extent and as provided for in any applicable law, including, without limitation, any state law based on the Uniform Electronic Transactions Act. 

14.14. Captions. Section headings herein are included herein for convenience of reference only and shall not constitute a part
hereof for any other purpose or be given any substantive effect. 
  

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 14.15. Construction of Agreement. The parties mutually acknowledge that they and
their attorneys have participated in the preparation and negotiation of this Agreement. In cases of uncertainty this Agreement shall be construed without regard to which of the parties caused the uncertainty to exist. 

14.16. Third Parties. Nothing in this Agreement, whether express or implied, is intended to: (a) confer any benefits, rights
or remedies under or by reason of this Agreement on any persons other than the express parties to it and their respective permitted successors and assigns; (b) relieve or discharge the obligation or liability of any person not an express party
to this Agreement; or (c) give any person not an express party to this Agreement any right of subrogation or action against any party to this Agreement. 

14.17. No Fiduciary Duty. The Administrative Agent, each Lender and their respective Affiliates (collectively, solely for purposes
of this paragraph, the “Lenders”), may have economic interests that conflict with those of the Credit Parties. Each Credit Party, its Subsidiaries and their respective affiliates each agrees that nothing in the Loan Documents or
otherwise will be deemed to create an advisory, fiduciary or agency relationship or fiduciary or other implied duty between the Lenders, on the one hand, and such Credit Party, its Subsidiaries, and any of their respective stockholders or
affiliates, on the other hand. Each Credit Party, its Subsidiaries and their respective affiliates each acknowledge and agree that (i) the transactions contemplated by the Loan Documents are arm’s-length commercial transactions between the
Lenders, on the one hand, and such Credit Party, its Subsidiaries and their respective affiliates, on the other, (ii) in connection therewith and with the process leading to such transaction each of the Lenders is acting solely as a principal
and not the agent or fiduciary of such Credit Party, its Subsidiaries or their respective affiliates, management, stockholders, creditors or any other person, (iii) no Lender has assumed an advisory or fiduciary responsibility in favor of any
Credit Party, its Subsidiaries or their respective affiliates with respect to the transactions contemplated hereby or the process leading thereto (irrespective of whether any Lender or any of its affiliates has advised or is currently advising such
Credit Party, its Subsidiaries or their respective affiliates on other matters) or any other obligation to such Credit Party, its Subsidiaries or their respective affiliates except the obligations expressly set forth in the Loan Documents and
(iv) each Credit Party, its Subsidiaries and their respective affiliates have consulted their own legal and financial advisors to the extent each deemed appropriate. Each Credit Party, its Subsidiaries and their respective affiliates further
acknowledges and agrees that it is responsible for making its own independent judgment with respect to such transactions and the process leading thereto. Each Credit Party, its Subsidiaries and their respective affiliates agrees that it will not
claim that any Lender has rendered advisory services of any nature or respect, or owes a fiduciary or similar duty to such Credit Party, its Subsidiaries or their respective affiliates in connection with such transaction or the process leading
thereto. 
 14.18. Borrower Liability. Either Borrower may, acting singly, request Term Loans hereunder. Each Borrower
hereby appoints the other as agent for the other for all purposes hereunder, including with respect to requesting Term Loans hereunder. Each Borrower hereunder shall be jointly and severally obligated to repay all Term Loans made hereunder,
regardless of which Borrower actually receives said Term Loan, as if each Borrower hereunder directly received all Term Loans. Each Borrower waives (a) any suretyship defenses available to it under the Code or any other applicable law,
including, without limitation, the benefit of California Civil Code Section 2815 permitting revocation as to future transactions and the benefit of California Civil Code Sections 1432, 2809, 2810, 2819, 2839, 2845, 2847, 2848, 2849, 2850, and
2899 and 3433, and (b) any right to require the Administrative Agent or the Lenders to: (i) proceed against any other Borrower or any other person; (ii) proceed against or exhaust any security; or (iii) pursue any other remedy.
The Administrative Agent and the Lenders may exercise or not exercise any right or remedy it has against any Borrower or any security it holds (including the right to foreclose by judicial or non judicial sale) without affecting any other
Borrower’s liability. Notwithstanding any other provision of this Agreement or other related document, each Borrower irrevocably waives all rights that it may have at law or in equity (including, without limitation, any law subrogating Borrower
to the rights of the Administrative Agent and the Lenders under this Agreement) to seek contribution, indemnification or any other form of reimbursement from any other Borrower, or any other Person now or hereafter primarily or secondarily liable
for any of the Obligations, for any payment made by Borrower with respect to the Obligations in connection with this Agreement or otherwise and all rights that it might have to benefit from, or to participate in, any security for the Obligations as
a result of any payment made by Borrower with respect to the Obligations in connection with this Agreement or otherwise. Any agreement providing for indemnification, reimbursement or any other arrangement prohibited under this Section shall be null
and void. If any payment is made to a Borrower in contravention of this Section, such Borrower shall hold such payment in trust for the Administrative Agent and the Lenders and such payment shall be promptly delivered to the Administrative Agent for
application to the Obligations, whether matured or unmatured. 
  

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 15. DEFINITIONS 

15.1. Definitions. As used in the Loan Documents, the word “shall” is mandatory, the word “may” is permissive,
the word “or” is not exclusive, the words “includes” and “including” are not limiting, the singular includes the plural, and numbers denoting amounts that are set off in brackets are negative. As used in this Agreement,
the following capitalized terms have the following meanings: 
 “10 Non-Bank Creditor Rule” shall have the
meaning set forth in Section 5.20. 
 “20 Non-Bank Creditor Rule” shall have the meaning set forth in
Section 5.20. 
 “Account” is any “account” as defined in the Code with such additions to such
term as may hereafter be made, and includes, without limitation, all accounts receivable and other sums owing to Credit Parties. 

“Account Debtor” is any “account debtor” as defined in the Code with such additions to such term as may
hereafter be made. 
 “Administrative Agent” is defined in the preamble hereof. 

“Advance Payment” is defined in Section 2.2(i). 

“Adverse Proceeding” means any action, suit, proceeding, hearing (whether administrative, judicial or otherwise),
governmental investigation or arbitration (whether or not purportedly on behalf of any Credit Party or any of its Subsidiaries) at law or in equity, or before or by any Governmental Authority, domestic or foreign (including any Environmental
Claims), whether pending or, to the knowledge of any Credit Party or any of its Subsidiaries, threatened against or adversely affecting any Credit Party or any of its Subsidiaries or any property of any Credit Party or any of its Subsidiaries.

 “Affiliate” is, with respect to any Person, each other Person that owns or controls directly or indirectly
the Person, any Person that controls or is controlled by or is under common control with the Person, and each of that Person’s senior executive officers, directors, partners and, for any Person that is a limited liability company, that
Person’s managers and members. 
 “Agreement” is defined in the preamble hereof. 

“Aggregate Amounts Due” is defined in Section 2.2(h). 

“Applicable Accounting Standards” means (i) with respect to Guarantor and Horizon, generally accepted accounting
principles in the United States as set forth in the opinions and pronouncements of the Accounting Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards
Board or in such other statements by such other Person as may be approved by a significant segment of the accounting profession, which are applicable to the circumstances as of the date of determination and, (ii) with respect to Nitec, the
International Financial Reporting Standards. 
 “Applicable Rate” is defined in Section 2.2(c).

 “Assignment Agreement” means an Assignment and Assumption Agreement in form reasonably satisfactory to the
Administrative Agent, with such amendments or modifications as may be approved by the Administrative Agent. 

“Assignment Effective Date” is defined in Section 14.1(b). 

“Bankruptcy Code” means Title 11 of the United States Code entitled “Bankruptcy,” as now and hereafter in
effect, or any successor statute. 
 “Board” means a Credit Party’s board of directors. 

 

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 “Board of Governors” means the Board of Governors of the United States
Federal Reserve System, or any successor thereto. 
 “Books” are all books and records including ledgers,
federal and state Tax returns, records regarding a Credit Party’s assets or liabilities, the Collateral, business operations or financial condition, and all computer programs or storage or any equipment containing such information. 

“Borrower” is defined in the preamble hereof. 

“Borrowing Resolutions” are, with respect to any Person, those resolutions adopted by such Person’s Board and
delivered by such Person to Administrative Agent approving the Loan Documents to which such Person is a party and the transactions contemplated thereby, together with a certificate executed by its Secretary on behalf of such Person certifying that
(a) such Person has the authority to execute, deliver, and perform its obligations under each of the Loan Documents to which it is a party, (b) that attached as Exhibit A to such certificate is a true, correct, and complete copy of the
resolutions then in full force and effect authorizing and ratifying the execution, delivery, and performance by such Person of the Loan Documents to which it is a party, (c) the name(s) of the Person(s) authorized to execute the Loan Documents
on behalf of such Person, together with a sample of the true signature(s) of such Person(s), and (d) that Administrative Agent may conclusively rely on such certificate unless and until such Person shall have delivered to Administrative Agent a
further certificate canceling or amending such prior certificate. 
 “Business Day” is any day that is not a
Saturday, Sunday or a day on which banks are not authorized or required to be closed in the City of San Francisco, California. 

“Cash Equivalents” means, with respect to Guarantor and Horizon, (a) marketable direct obligations issued or
unconditionally guaranteed by the United States or any agency or any State thereof having maturities of not more than one (1) year from the date of acquisition; (b) commercial paper maturing no more than one (1) year after its
creation and having the highest rating from either Standard & Poor’s Ratings Group or Moody’s Investors Service, Inc.; and (c) Silicon Valley Bank’s money market funds or certificates of deposit issued by Silicon Valley
Bank maturing no more than one (1) year after issue, and, with respect to Nitec, deposits held at call with banks and other short-term, highly liquid investments, which are readily convertible to known amounts of cash (and which are subject to
insignificant risk of changes in value) and have a maturity of three months or less from the date of acquisition. 

“Code” is the Uniform Commercial Code, as the same may, from time to time, be enacted and in effect in the State of
California; provided, that, to the extent that the Code is used to define any term herein or in any Loan Document and such term is defined differently in different Articles or Divisions of the Code, the definition of such term contained in Article
or Division 9 shall govern; provided further, that in the event that, by reason of mandatory provisions of law, any or all of the attachment, perfection, or priority of, or remedies with respect to, the Administrative Agent’s Lien on any
Collateral is governed by the Uniform Commercial Code in effect in a jurisdiction other than the State of California, the term “Code” shall mean the Uniform Commercial Code as enacted and in effect in such other jurisdiction solely
for purposes of the provisions thereof relating to such attachment, perfection, priority, or remedies and for purposes of definitions relating to such provisions. 

“Collateral” is any and all properties, rights and assets of Credit Parties described on Exhibit A. 

“Collateral Account” is any Deposit Account, Securities Account, or Commodity Account. 

“Collateral Documents” means all instruments, documents and agreements delivered by any Credit Party pursuant to this
Agreement or any of the other Loan Documents, in each case in order to grant to the Administrative Agent, for the benefit of Lenders, or perfect, a Lien on any real, personal or mixed property of that Credit Party as security for the Obligations.

 “Commitment Fee” is defined in Section 2.3(a). 

“Commodity Account” is any “commodity account” as defined in the Code with such additions to such term as may
hereafter be made. 
  

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 “Compliance Certificate” is that certain certificate in the form attached
hereto as Exhibit C. 
 “Contingent Obligation” is, for any Person, any direct or indirect liability,
contingent or not, of that Person for (a) any indebtedness, lease, dividend, letter of credit or other obligation of another such as an obligation, in each case, directly or indirectly guaranteed, endorsed, co made, discounted or sold with
recourse by that Person, or for which that Person is directly or indirectly liable; (b) any obligations for undrawn letters of credit for the account of that Person; and (c) all obligations from any interest rate, currency or commodity
swap agreement, interest rate cap or collar agreement, or other agreement or arrangement designated to protect a Person against fluctuation in interest rates, currency exchange rates or commodity prices; but “Contingent Obligation” does
not include endorsements in the ordinary course of business. The amount of a Contingent Obligation is the stated or determined amount of the primary obligation for which the Contingent Obligation is made or, if not determinable, the maximum
reasonably anticipated liability for it determined by the Person in good faith; but the amount may not exceed the maximum of the obligations under any guarantee or other support arrangement. 

“Control Agreement” is any control agreement entered into among the depository institution at which a Credit Party
maintains a Deposit Account or the securities intermediary or commodity intermediary at which a Credit Party maintains a Securities Account or a Commodity Account, such Credit Party, and the Administrative Agent pursuant to which the Administrative
Agent obtains control (within the meaning of the Code) over such Deposit Account, Securities Account, or Commodity Account. 

“Copyrights” are any and all copyright rights, copyright applications, copyright registrations and like protections in
each work of authorship and derivative work thereof, whether published or unpublished and whether or not the same also constitutes a trade secret. 

“Credit Extension” is any Term Loan or any other extension of credit by the Lenders for a Borrower’s benefit.

 “Credit Party” is defined in the preamble hereof 

“Default Excess” means, with respect to any Defaulting Lender, the excess, if any, of such Defaulting Lender’s Pro
Rata Share of the aggregate outstanding principal amount of Term Loans of all Lenders (calculated as if all Defaulting Lenders (including such Defaulting Lender) had funded all of their respective Defaulted Loans) over the aggregate outstanding
principal amount of all Term Loans of such Defaulting Lender. 
 “Default Period” means, with respect to any
Defaulting Lender, the period commencing on the date of the applicable Funding Default and ending on the earliest of the following dates: (i) the date on which all Term Commitments are cancelled or terminated and/or the Obligations are declared
or become immediately due and payable, (ii) the date on which the Default Excess with respect to such Defaulting Lender shall have been reduced to zero and (iii) the date on which Credit Parties, Administrative Agent and Requisite Lenders
waive all Funding Defaults of such Defaulting Lender in writing. 
 “Defaulted Loan” is defined in
Section 2.8. 
 “Defaulting Lender” is defined in Section 2.8. 

“Deposit Account” is any “deposit account” as defined in the Code with such additions to such term as may
hereafter be made. 
 “Dollars,” “dollars” or use of the sign “$” means only lawful
money of the United States and not any other currency, regardless of whether that currency uses the “$” sign to denote its currency or may be readily converted into lawful money of the United States. 

“Effective Date” is defined in the preamble hereof. 

“Eligible Assignee” means (i) any Lender, any Affiliate of any Lender and any Related Fund (any two or more Related
Funds being treated as a single Eligible Assignee for all purposes hereof), and (ii) any commercial bank, insurance company, investment or mutual fund or other entity that is an “accredited investor” (as defined in

  

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Regulation D under the Securities Act) and which extends credit or buys loans; provided, neither any Credit Party nor any of its Subsidiaries shall be an Eligible Assignee. 

“Environmental Claim” means any investigation, notice, notice of violation, claim, action, suit, proceeding, demand,
abatement order or other order or directive (conditional or otherwise), by any Governmental Authority or any other Person, arising (i) pursuant to or in connection with any actual or alleged violation of any Environmental Law; (ii) in
connection with any Hazardous Material or any actual or alleged Hazardous Materials Activity; or (iii) in connection with any actual or alleged damage, injury, threat or harm to health, safety, natural resources or the environment. 

“Environmental Laws” means any and all current or future foreign or domestic, federal or state (or any subdivision of
either of them), statutes, ordinances, orders, rules, regulations, judgments, Governmental Authorizations, or any other requirements of Governmental Authorities relating to (i) environmental matters, including those relating to any Hazardous
Materials Activity; (ii) the generation, use, storage, transportation or disposal of Hazardous Materials; or (iii) occupational safety and health, industrial hygiene, land use or the protection of human, plant or animal health or welfare,
in any manner applicable to any Credit Party or any of its Subsidiaries or any Facility. 
 “Equipment” is all
“equipment” as defined in the Code with such additions to such term as may hereafter be made, and includes without limitation all machinery, fixtures, goods, vehicles (including motor vehicles and trailers), and any interest in any of the
foregoing. 
 “Equity Interests” means any and all shares, interests, participations or other equivalents
(however designated) of capital stock of a corporation, any and all equivalent ownership interests in a Person (other than a corporation), including partnership interests and membership interests, and any and all warrants, rights or options to
purchase or other arrangements or rights to acquire any of the foregoing. 
 “ERISA” is the Employee Retirement
Income Security Act of 1974, and its regulations. 
 “Event of Default” is defined in Section 9.

 “Exchange Act” is the Securities Exchange Act of 1934, as amended from time to time, and any successor
statute. 
 “Existing Kreos Loan Agreement” means that certain Agreement for the Provision of a Loan Facility
of up to Euro 7,500,000, dated August 15, 2008, by and between Kreos Capital III (UK) Limited and Nitec, as amended, restated, or otherwise modified. 

“Facility” means any real property (including all buildings, fixtures or other improvements located thereon) now,
hereafter or heretofore owned, leased, operated or used by any Credit Party or any of its Subsidiaries or any of their respective predecessors or Affiliates. 

“FDA” shall mean the Food and Drug Administration, any successor thereto, and any analogous Governmental Authority.

 “Federal Reserve Board” means the Board of Governors of the Federal Reserve System. 

“Financing Event” is either (i) the closing of a Qualified IPO or (ii) receipt by Guarantor of gross cash
proceeds of not less than $10,000,000 from the issuance and sale of Guarantor’s subordinated convertible promissory notes comprising the second tranche of the financing contemplated by the terms of that certain Series B Preferred Stock and
Subordinated Convertible Note Purchase Agreement, dated as of April 1, 2010, as the same may be amended from time to time. 

“First Term Loan” is defined in Section 2.2. 

“Funding Date” is any date on which a Credit Extension is made to or for the account of a Borrower which shall be a
Business Day. 
  

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 “Funding Default” is defined in Section 2.8. 

“General Intangibles” is all “general intangibles” as defined in the Code in effect on the date hereof with
such additions to such term as may hereafter be made, and includes without limitation, all Intellectual Property, claims, income and other Tax refunds, security and other deposits, payment intangibles, contract rights, options to purchase or sell
real or personal property, rights in all litigation presently or hereafter pending (whether in contract, tort or otherwise), insurance policies (including without limitation key man, property damage, and business interruption insurance), payments of
insurance and rights to payment of any kind. 
 “Governmental Approval” is any consent, authorization,
approval, order, license, franchise, permit, certificate, accreditation, registration, filing or notice, of, issued by, from or to, or other act by or in respect of, any Governmental Authority. 

“Governmental Authority” is any nation or government, any state or other political subdivision thereof, any agency,
authority, instrumentality, regulatory body, court, central bank or other entity exercising executive, legislative, judicial, taxing, regulatory or administrative functions of or pertaining to government, any securities exchange and any
self-regulatory organization. 
 “Guaranteed Obligations” is defined in Section 8.1. 

“Guarantor” is defined in the preamble hereof. 

“Hazardous Materials” means any chemical, material or substance, exposure to which is prohibited, limited or regulated
by any Governmental Authority or which may or could pose a hazard to the health and safety of the owners, occupants or any Persons in the vicinity of any Facility or to the indoor or outdoor environment. 

“Hazardous Materials Activity” means any past, current, proposed or threatened activity, event or occurrence involving
any Hazardous Materials, including the use, manufacture, possession, storage, holding, presence, existence, location, Release, threatened Release, discharge, placement, generation, transportation, processing, construction, treatment, abatement,
removal, remediation, disposal, disposition or handling of any Hazardous Materials, and any corrective action or response action with respect to any of the foregoing. 

“Horizon” is defined in the preamble hereof. 

“Indebtedness” is (a) indebtedness for borrowed money or the deferred price of property or services, such as
reimbursement and other obligations for surety bonds and letters of credit, (b) obligations evidenced by notes, bonds, debentures or similar instruments, (c) capital lease obligations, and (d) Contingent Obligations. 

“Indemnified Liabilities” means, collectively, any and all liabilities, obligations, losses, damages (including natural
resource damages), penalties, claims, actions, judgments, suits, costs, expenses and disbursements of any kind or nature whatsoever (including the reasonable fees and disbursements of counsel for Indemnified Persons in connection with any
investigative, administrative or judicial proceeding or hearing commenced or threatened by any Person, whether or not any such Indemnified Person shall be designated as a party or a potential party thereto (it being agreed that, such counsel fees
and expenses shall be limited to one primary counsel, and any additional special and local counsel in each appropriate jurisdiction, for the Indemnified Persons, except in the case of actual or potential conflicts of interest between or among the
Indemnified Persons), and any fees or expenses incurred by Indemnified Persons in enforcing this indemnity), whether direct, indirect or consequential and whether based on any federal, state or foreign laws, statutes, rules or regulations, on common
law or equitable cause or on contract or otherwise, that may be imposed on, incurred by, or asserted against any such Indemnified Person, in any manner relating to or arising out of this Agreement or the other Loan Documents or the transactions
contemplated hereby or thereby (including the Lenders’ agreement to make Credit Extensions or the use or intended use of the proceeds thereof, or any enforcement of any of the Loan Documents (including any sale of, collection from, or other
realization upon any of the Collateral or the enforcement of the Guaranty)). 
 “Indemnified Person” is defined
in Section 14.2. 
 “Interim Payment” is defined in Section 2.2(f). 

 

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 “Insolvency Proceeding” is any proceeding by or against any Person under
the United States Bankruptcy Code, or any other bankruptcy or insolvency law, including assignments for the benefit of creditors, compositions, extensions generally with its creditors, or proceedings seeking reorganization, arrangement, or other
relief. 
 “Intellectual Property” means all of Borrower’s right, title, and interest in and to the
following: 
 (a) its Copyrights, Trademarks and Patents; 

(b) any and all trade secrets and trade secret rights, including, without limitation, any rights to unpatented inventions, know-how,
operating manuals; 
 (c) any and all source code; 

(d) any and all design rights which may be available to a Borrower; 

(e) any and all claims for damages by way of past, present and future infringement of any of the foregoing, with the right, but not the
obligation, to sue for and collect such damages for said use or infringement of the Intellectual Property rights identified above; and 

(f) all amendments, renewals and extensions of any of the Copyrights, Trademarks or Patents. 

“Intellectual Property Collateral” means, as to each Credit Party, all of such Credit Party’s right, title and
interest in and to any Intellectual Property. 
 “Indemnitees” is defined in Section 2.9(b). 

“Inventory” is all “inventory” as defined in the Code in effect on the date hereof with such additions to such
term as may hereafter be made, and includes without limitation all merchandise, raw materials, parts, supplies, packing and shipping materials, work in process and finished products, including without limitation such inventory as is temporarily out
of a Credit Party’s custody or possession or in transit and including any returned goods and any documents of title representing any of the above. 

“Investment” is any beneficial ownership interest in any Person (including stock, partnership interest or other
securities), and any loan, advance or capital contribution to any Person. 
 “IP Collateral Proceeds” means all
Accounts, license and royalty fees and other revenues, proceeds or income arising out of or relating to any of the Intellectual Property Collateral and any claims for damages by way of any past, present or future infringement of any of the
Intellectual Property Collateral. 
 “IRC” shall mean the Internal Revenue Code of 1986, as amended, and any
successor thereto, and any regulations promulgated thereunder. 
 “Knowledge,” to the “best of Credit
Party’s knowledge” or similar qualifications means the actual knowledge, after reasonable investigation, of the Responsible Officers. 

“Lender” and “Lenders” shall have the respective meanings set forth in the first paragraph of this
Agreement and shall include any assignee or participant of a Loan in accordance with Section 14.1 hereof. 

“Lender Expenses” are all audit fees and expenses, costs, and expenses (including reasonable attorneys’ fees and
expenses) for preparing, amending, negotiating, administering, defending and enforcing the Loan Documents (including, without limitation, those incurred in connection with appeals or Insolvency Proceedings) or otherwise incurred with respect to the
Credit Parties. 
 “Lien” is a claim, mortgage, deed of trust, levy, charge, pledge, security interest or other
encumbrance of any kind, whether voluntarily incurred or arising by operation of law or otherwise against any property. 
  

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 “Loan Documents” are, collectively, this Agreement, any Term Notes, the
Warrants, the Perfection Certificates, any Control Agreement, any Collateral Document, any guaranties executed by a Credit Party, including, without limitation, the Nitec Debt Guaranty, and any other present or future agreement between a Credit
Party and the Administrative Agent, in each case for the benefit of the Lenders, in connection with this Agreement, all as amended, restated, or otherwise modified. 

“Margin Stock” is defined in Section 5.13. 

“Material Adverse Change” is (a) a material impairment in the perfection or priority of the Administrative
Agent’s Lien in the Collateral or in the value of such Collateral, (b) a material adverse change in the business, operations, or condition (financial or otherwise) of Borrower, or (c) a material impairment of the prospect of repayment
of any portion of the Obligations. 
 “Material Contract” means any contract or other arrangement to which a
Credit Party or any of its Subsidiaries is a party (other than the Loan Documents) for which breach, nonperformance, cancellation or failure to renew could reasonably be expected to result in a Material Adverse Change. 

“Monthly Financial Statements” is defined in Section 6.2(a)(i). 

“Monthly Payment” is defined in Section 2.2(e). 

“Nitec” is defined in the preamble hereof. 

“Nitec Collateral” means any and all properties, rights and assets of Nitec described on Exhibit A. 

“Nitec Debt Guaranty” means the Guaranty Agreement, in the form attached hereto as Exhibit D, pursuant to which
Guarantor and Horizon have guaranteed the satisfaction of all obligations of Nitec under the Existing Kreos Loan Agreement. 

“Nitec Release Event” means, on the date of determination, (a) the Credit Parties shall have obtained FDA approval
for Deuxa and (b) either (i) Guarantor and Horizon shall have achieved cumulative gross revenues from the sale of Deuxa or Lodotra products of not less than $50,000,000 (and shall have rights, through ownership or license of the
related Intellectual Property to continue to sell the products from which such revenues were derived until payment in full in cash of the Obligations (other than inchoate indemnity obligations) and termination of the Lenders’ obligations to
make Credit Extensions hereunder) or (ii) Guarantor and Horizon shall have the Required Liquidity and delivered to the Administrative Agent and the Lenders projections, in form satisfactory to the Administrative Agent and the Lenders, for the
following twelve (12) month period demonstrating, to the satisfaction of the Administrative Agent and the Lenders, that the Required Liquidity will be an amount sufficient to finance the operations of the Credit Parties in the ordinary course
of business for such following twelve (12) month period. 
 “Nonpublic Information” means information
which has not been disseminated in a manner making it available to investors generally, within the meaning of Regulation FD. 

“Non U.S. Lender” is defined in Section 2.7(c). 

“Obligations” are the Credit Parties’ obligations to pay when due any debts, principal, interest, Lender Expenses
and other amounts Credit Parties owe the Administrative Agent, for the ratable benefit of the Lenders, now or later, whether under this Agreement, the Loan Documents, or otherwise, including, without limitation, all obligations relating to letters
of credit (including reimbursement obligations for drawn and undrawn letters of credit), cash management services, and foreign exchange contracts, if any, and including interest accruing after Insolvency Proceedings begin and debts, liabilities, or
obligations of Borrowers assigned to the Administrative Agent, for the ratable benefit of the Lenders, and to perform Borrowers’ duties under the Loan Documents; provided that the term “Obligations” shall not include any obligations
to pay or perform under the Warrants. For the avoidance of doubt, the obligations of Guarantor and Horizon under the Nitec Debt Guaranty shall constitute Obligations under this Agreement for all purposes. 

“Obligee Guarantor” is defined in Section 8.6. 

 

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 “Operating Documents” are, for any Person, such Person’s formation
documents, as certified with the Secretary of State or other applicable Governmental Authority of such Person’s jurisdiction of formation on a date that is no earlier than 30 days prior to the Effective Date, and, (a) if such Person is a
corporation, its bylaws in current form, (b) if such Person is a limited liability company, its limited liability company agreement (or similar agreement), and (c) if such Person is a partnership, its partnership agreement (or similar
agreement), each of the foregoing with all current amendments or modifications thereto. 
 “Patents” means all
patents, patent applications and like protections including without limitation improvements, divisions, continuations, renewals, reissues, extensions and continuations-in-part of the same. 

“Patriot Act” is defined in Section 3.1(m). 

“Payment/Advance Form” is that certain form attached hereto as Exhibit B. “Payment Date”
is the first day of each calendar month. 
 “Perfection Certificate” is defined in Section 5.5.

 “Permitted Account” is defined in Section 6.6. 

“Permitted Indebtedness” is: 

(a) Credit Parties’ Indebtedness to the Lenders under this Agreement and the other Loan Documents; 

(b) Indebtedness existing on the Effective Date and shown on the Perfection Certificate; 

(c) Subordinated Debt; 

(d) unsecured Indebtedness to trade creditors incurred in the ordinary course of business; 

(e) Indebtedness incurred as a result of endorsing negotiable instruments received in the ordinary course of business; 

(f) Indebtedness secured by Liens permitted under clauses (a) and (c) of the definition of “Permitted Liens”
hereunder; and 
 (g) extensions, refinancings, modifications, amendments and restatements of any items of Permitted
Indebtedness (a) through (1) above, provided that the principal amount thereof is not increased or the terms thereof are not modified to impose more burdensome terms upon any Credit Party or its Subsidiaries, as the case may be.

 “Permitted Investments” are: 

(a) Investments (including, without limitation, Subsidiaries) existing on the Effective Date and shown on the Perfection Certificate;

 (b) Investments consisting of Cash Equivalents; 

(c) Investments consisting of the endorsement of negotiable instruments for deposit or collection or similar transactions in the ordinary
course of business; 
 (d) Subject to Section 6.6, Investments consisting of deposit accounts or securities
accounts; 
 (e) Investments accepted in connection with Permitted Licenses; 

(f) Until the Nitec Release Event Completion Date, (i) Investments by any Credit Party in or to any other Credit Party, and
(ii) Investments by Nitec in or to any Subsidiary of Nitec for the payment of ordinary course 
  

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operating expenses, so long as the outstanding aggregate amount of all such Investments shall not exceed Five Hundred Thousand Dollars $(500,000) as of the end of any calendar month, and on or
after the Nitec Release Event Completion Date (A) Investments by Guarantor in or to Horizon or Investments by Horizon in or to Guarantor, (B) Investments by Nitec in or to Horizon or Guarantor, (C) Investments by Nitec in or to any
Subsidiary of Nitec for the payment of ordinary course operating expenses or Investments by any Subsidiaries of Nitec in or to Nitec; provided that the aggregate outstanding amount of all Investments permitted pursuant to this clause (C) shall
not exceed Five Hundred Thousand Dollars $(500,000) as of the end of any calendar month, and (D) Investments by Guarantor or Horizon in Nitec, provided that at the time of and after giving effect to any such Investment, and at all times any
such Investment is outstanding, Guarantor and Horizon have “Excess Cash” on deposit in an account with SVB or one of its Affiliates in an aggregate amount at least equal to the total amount of the Obligations outstanding at the date of
determination. For purposes of clause (D) immediately preceding, “Excess Cash” means cash or Cash Equivalents in an aggregate amount in excess of the amount required by Horizon and Guarantor to meet its operating expenses for
the succeeding four calendar months based on the immediately prior four calendar months; 
 (g) Investments consisting of
(x) travel advances and employee relocation loans and other employee advances in the ordinary course of business, and (y) loans to employees, officers or directors relating to the purchase of equity securities of Guarantor pursuant to
employee stock purchase plans or agreements approved by Guarantor’s Board, so long as the aggregate amount of all such loans made pursuant to this clause (g) do not exceed Two Hundred and Fifty Thousand Dollars ($250,000); 

(h) Investments (including debt obligations) received in connection with the bankruptcy or reorganization of customers or suppliers and
in settlement of delinquent obligations of, and other disputes with, customers or suppliers arising in the ordinary course of business; 

(i) Investments consisting of notes receivable of, or prepaid royalties and other credit extensions, to customers and suppliers who are
not Affiliates, in the ordinary course of business; provided that this paragraph (i) shall not apply to Investments of any Credit Party in any Subsidiary; and 

(j) joint ventures or strategic alliances in the ordinary course of business consisting of the nonexclusive licensing of technology, the
development of technology or the providing of technical support, but in no event consisting of cash investments. 

“Permitted Licenses” means (a) a non-exclusive or exclusive as to geography other than the United States license of
Intellectual Property granted to third parties in the in the ordinary course of business, (b) subject to prior satisfaction of the requirements set forth in the following sentence, an exclusive as to geography within the United States license
of Intellectual Property granted to third parties in the in the ordinary course of business, (c) nonexclusive licensing of technology, the development of technology or the providing of technical support, (d) nonexclusive or exclusive
manufacturing licenses, or (e) intercompany licenses or other similar arrangements among the Credit Parties; provided, however, that the licenses or similar arrangements described in clause (e) above shall not permit exclusive as to
geography in the United States licenses of Intellectual Property and shall only permit exclusive as to geography other than the United States licenses of Intellectual Property if Guarantor or Horizon retains all rights to such Intellectual Property
other than those rights that are the subject of such license. Notwithstanding the foregoing, any license described in clause (b) above shall not be a Permitted License hereunder unless and until (i) such Credit Party that is to be a party
to such license shall have given written notice of such proposed license, which notice shall (A) identify the parties to the proposed license, (B) include a description of the material terms and conditions of such proposed license and
(C) include copies of any and all agreements relating to such proposed license, to the Administrative Agent and to each Lender in accordance with Section 12 hereof, (ii) the Administrative Agent shall have given written
acknowledgment of receipt of the foregoing notice, and (iii) the Administrative Agent shall have given its written consent to such proposed license; provided that, in the event such requesting Credit Party does not receive a written denial
thereof within ten (10) Business Days after the Administrative Agent’s acknowledgement of receipt of such request as contemplated in clause (ii) above, then the Administrative Agent will be deemed to have given such consent, and such
Credit Party shall be permitted to enter into such license arrangement, unless the material terms and conditions of such proposed license have changed in any respect from the terms set forth in the materials provided to the Administrative Agent
pursuant to clause (i) above, in which event consent shall not be deemed to have been given by the Administrative Agent until such time as the requirements of clauses (i) through (iii) have been satisfied as to the proposed license,
as so amended or modified. 
  

 -51- 

 “Permitted Liens” are: 

(a) Liens existing on the Effective Date and shown on the Perfection Certificate or arising under this Agreement and the other Loan
Documents; 
 (b) Liens for Taxes, fees, assessments or other government charges or levies, either (i) not due and payable
or (ii) being contested in good faith and for which such Credit Party maintains adequate reserves on its Books, provided that no notice of any such Lien has been filed or recorded under the Internal Revenue Code of 1986, as amended, and the
Treasury Regulations adopted thereunder; 
 (c) purchase money Liens (including capital leases) (i) on Equipment acquired
or held by a Credit Party incurred for financing the acquisition of the Equipment securing no more than Seven Hundred and Fifty Thousand Dollars ($750,000)] in the aggregate amount outstanding, or (ii) existing on Equipment when acquired, if
the Lien is confined to the property and improvements and the proceeds of the Equipment; 
 (d) Permitted Licenses; 

(e) Liens of carriers, warehousemen, suppliers, or other Persons that are possessory in nature arising in the ordinary course of business
so long as no such Lien secures liabilities in an amount in excess of One Hundred Thousand Dollars ($100,000), individually, or Two Hundred and Fifty Thousand Dollars ($250,000), in the aggregate, when aggregated with all such Liens, and in each
case, is not delinquent or remains payable without penalty or is being contested in good faith and by appropriate proceedings which proceedings have the effect of preventing the forfeiture or sale of the property subject thereto; 

(f) Liens to secure payment of workers’ compensation, employment insurance, old-age pensions, social security and other like
obligations incurred in the ordinary course of business (other than Liens imposed by ERISA); 
 (g) Liens arising from
attachments or judgments, orders, or decrees in circumstances not constituting an Event of Default under either Section 9.4 or 9.7; 

(h) subject to Section 6.6, Liens in favor of other financial institutions arising in connection with deposit and/or
securities accounts held at such institutions; provided that such Liens relate solely to obligations for administrative and other banking fees and expenses incurred in the ordinary course of business in connection with the maintenance of such
accounts; 
 (i) statutory or common law Liens of landlords; provided that such landlords shall have waived their respective
rights with respect to such Liens pursuant to a landlord waiver agreement between such landlord and the Administrative Agent in form satisfactory to the Administrative Agent; 

(j) Liens incurred or deposits made to secure the performance of tenders, bids, leases, statutory or regulatory obligations, surety and
appeal bonds, government contracts, performance and return-of-money bonds, and other obligations of like nature, in each case, in the ordinary course of business; provided, that at no such time shall the aggregate amount of all such Liens exceed One
Hundred Thousand Dollars ($100,000); 
 (k) pledges and deposits securing liability for reimbursement or indemnification
obligations in respect of letters of credit or bank guarantees for the benefit of landlords; provided, that at no such time shall the aggregate amount of all such pledges and deposits exceed One Hundred Thousand Dollars ($100,000); and 

(l) Liens incurred in the extension, renewal or refinancing of the indebtedness secured by Liens described in (a) through (j), but
any extension, renewal or replacement Lien must be limited to the property encumbered by the existing Lien and the principal amount of the indebtedness may not increase. 

“Person” is any individual, sole proprietorship, partnership, limited liability company, joint venture, company, trust,
unincorporated organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or government agency. 
  

 -52- 

 “Pro Rata Share” means with respect each Lender, the percentage obtained by
dividing (a) the Term Commitment of that Lender by (b) the aggregate Term Commitments of all Lenders. 

“Qualified IPO” means receipt by Guarantor of gross cash proceeds (before deduction of underwriter commissions and
expenses) of not less than $50,000,000 from the issuance and sale of Guarantor’s equity securities to the public pursuant to an offering registered under the Securities Act. 

“Qualifying Lender” means (as per the explanatory notes of the Swiss Federal Tax Administration
S-02.122.1 (4.99), S-02.122.2 (4.99) and S-02.128 (1.2000), as amended, restated, supplemented or otherwise modified from time to time) any entity, which effectively conducts banking activities with its own infrastructure and staff as principal
purpose and which is recognized as a bank by the banking laws in force in the jurisdiction of incorporation. 

“Register” is defined in Section 2.9(b). 

“Registered Organization” is any “registered organization” as defined in the Code with such additions to such
term as may hereafter be made. 
 “Regulation FD” means Regulation FD as promulgated by the U.S. Securities and
Exchange Commission under the Securities Act and Exchange Act as in effect from time to time. 
 “Related Fund”
means, with respect to any Lender that is an investment fund, any other investment fund that invests in commercial loans and that is managed or advised by the same investment advisor as such Lender or by an Affiliate of such investment advisor.

 “Release” means any release, spill, emission, leaking, pumping, pouring, injection, escaping, deposit,
disposal, discharge, dispersal, dumping, leaching or migration of any Hazardous Material into the indoor or outdoor environment (including the abandonment or disposal of any barrels, containers or other closed receptacles containing any Hazardous
Material), including the movement of any Hazardous Material through the air, soil, surface water or groundwater. 

“Required Liquidity”, as of any date of determination, shall mean the aggregate of the Credit Parties’ cash and
Cash Equivalents in an amount not less than the aggregate net reduction in the Credit Parties’ operating cash position for the immediately preceding three month period, multiplied by four (4). 

“Requirement of Law” is as to any Person, the organizational or governing documents of such Person, and any law
(statutory or common), treaty, rule or regulation or determination of an arbitrator or a court or other Governmental Authority, in each case applicable to or binding upon such Person or any of its property or to which such Person or any of its
property is subject. 
 “Requisite Lenders” means one or more Lenders having or holding, as of any date of
determination, a majority of the aggregate principal amount of all Term Loans then outstanding. 
 “Responsible
Officer” is any of the Chief Executive Officer, President, Chief Financial Officer and Controller of any Credit Party. 

“Restricted License” is any material license or other agreement with respect to which a Credit Party is the licensee
(a) that prohibits or otherwise restricts such Credit Party from granting a security interest in such Credit Party’s interest in such license or agreement or any other property, or (b) for which a default under or termination of which
could interfere with the Administrative Agent’s right to sell any Collateral. 
 “SEC” shall mean the
Securities and Exchange Commission, any successor thereto, and any analogous Governmental Authority. 
 “Second Draw
Period” is the period commencing on the occurrence of the Financing Event and ending on the earlier to occur of (a) December 31, 2010 or (b) an Event of Default. 

 

 -53- 

 “Second Term Loan” is defined in Section 2.2. 

“Securities” means any stock, shares, partnership interests, voting trust certificates, certificates of interest or
participation in any profit sharing agreement or arrangement, options, warrants, bonds, debentures, notes, or other evidences of indebtedness, secured or unsecured, convertible, subordinated or otherwise, or in general any instruments commonly known
as “securities” or any certificates of interest, shares or participations in temporary or interim certificates for the purchase or acquisition of, or any right to subscribe to, purchase or acquire, any of the foregoing. 

“Securities Account” is any “securities account” as defined in the Code with such additions to such term as
may hereafter be made. 
 “Securities Act” means the Securities Act of 1933, as amended from time to time, and
any successor statute. 
 “Solvent” means, with respect to any Person on any date of determination, that on
such date (a) the fair value of the property of such Person is greater than the total amount of liabilities, including contingent liabilities, of such Person, (b) the present fair salable value of the assets of such Person is not less than
the amount that will be required to pay the probable liability of such Person on its debts as they become absolute and matured, (c) such Person will not be left with unreasonably small capital, and (d) such Person is able to both service
and pay its liabilities as they mature. In computing the amount of contingent or, unliquidated liabilities at any time, such liabilities will be computed as the amount that, in light of all the facts and circumstances existing at such time,
represents the amount that is likely to become an actual or matured liability. 
 “Subordinated Debt” is
(i) indebtedness incurred by Guarantor pursuant to Guarantor’s subordinated convertible promissory notes comprising the second tranche of the financing contemplated by the terms of that certain Series B Preferred Stock and Subordinated
Convertible Note Purchase Agreement, dated as of April 1, 2010, as the same may be amended from time to time, and (ii) indebtedness incurred by any Credit Party subordinated to all of such Credit Party’s now or hereafter incurred
indebtedness to the Lenders (pursuant to a subordination, intercreditor, or other similar agreement in form and substance satisfactory to the Administrative Agent entered into between the Administrative Agent and the other creditor), on terms
acceptable to the Administrative Agent. 
 “Subsidiary” is, as to any Person, a corporation, partnership,
limited liability company or other entity of which shares of stock or other ownership interests having ordinary voting power (other than stock or such other ownership interests having such power only by reason of the happening of a contingency) to
elect a majority of the board of directors or other managers of such corporation, partnership or other entity are at the time owned, or the management of which is otherwise controlled, directly or indirectly through one or more intermediaries, or
both, by such Person. Unless the context otherwise requires, each reference to a Subsidiary herein shall be a reference to a Subsidiary of a Credit Party. 

“Tax” means any present or future tax, levy, impost, duty, assessment, charge, fee, deduction or withholding of any
nature and whatever called, by whomsoever, on whomsoever and wherever imposed, levied, collected, withheld or assessed, including any tax of any kind whatsoever (whether disputed or not) imposed by any Governmental Authority with respect to any
Credit Party or any of its Subsidiaries or with respect to any member of a consolidated, affiliated, combined or unitary group in which any Credit Party or any of its Subsidiaries is or has been a member, including any related charges, fees,
interest, penalties, additions to tax or other assessments (including as a result of any obligation arising out of an agreement to indemnify any other Person); provided, “Tax on the overall net income” of a Person shall be construed as a
reference to a tax imposed by the jurisdiction in which that Person is organized or in which that Person’s applicable principal office (and/or, in the case of a Lender, its lending office) is located or in which that Person (and/or, in the case
of a Lender, its lending office) is deemed to be doing business on all or part of the net income, profits or gains (whether worldwide, or only insofar as such income, profits or gains are considered to arise in or to relate to a particular
jurisdiction, or otherwise) of that Person (and/or, in the case of a Lender, its applicable lending office). 
 “Term
Commitment” means the commitment of a Lender to make or otherwise fund any Term Loan and “Term Commitments” means such commitments of all Lenders in the aggregate. The amount of each Lender’s

  

 -54- 

 
Term Commitment, if any, is set forth on Appendix A, subject to any adjustment or reduction pursuant to the terms and conditions hereof. The aggregate amount of the Term Commitments as of
the Effective Date is $12,000,000. 
 “Term Loan” is defined in Section 2.2. 

“Term Loan Maturity Date” is, for each Term Loan, the date which is thirty-six (36) months after the first Payment
Date with respect to such Term Loan. 
 “Term Loan Note” means a promissory note in form reasonably acceptable
to the Administrative Agent and the Lenders, as it may be amended, restated, supplemented or otherwise modified from time to time. 

“Trademarks” means any trademark and servicemark rights, whether registered or not, applications to register and
registrations of the same and like protections, and the entire goodwill of the business of the Credit Party connected with and symbolized by such trademarks. 

“Transfer” is defined in Section 7.1. 

“Warrants” are those certain Warrants to Purchase Series B Preferred Stock, dated as of the Effective Date, executed by
Guarantor in favor of each Lender. 
 “U.S. Lender” is defined in Section 2.7(c). 

[Signature page follows.] 
  

 -55- 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as
of the Effective Date. 
  

							
	 HORIZON PHARMA USA, INC.,

as Borrower
	 		 	
				
	By:	 	 /s/ Timothy P. Walbert
	 		 	
	Name:	 	Timothy P. Walbert	 		 	
	Title:	 	President & CEO	 		 	
			
	 NITEC PHARMA AG,

as Borrower
	 		 	
				
	By:	 	 /s/ Anders Härfstrand
	 		 	 /s/ Jochen Mattis

	Name:	 	Anders Härfstrand	 		 	Jochen Mattis EVP
	Title:	 	CEO	 		 	
			
	 HORIZON PHARMA, INC.,

as Guarantor
	 		 	
				
	By:	 	 /s/ Timothy P. Walbert
	 		 	
	Name:	 	Timothy P. Walbert	 		 	
	Title:	 	President & CEO	 		 	

			
	 KREOS CAPITAL III (UK) LIMITED,

as Lender

		
	By:	 	 /s/ Maurizio Petitbon

	Name:	 	MAURIZIO PETITBON
	Title:	 	DIRECTOR

  

					
	Address for notices:	  	
		 		  	 Kreos Capital III (UK) Limited

25-28 Old Burlington Street
 London WIS
3AN
 Attn: Donatella Callegaris
 Fax:
+44 (0)20-7409-1034
 Email: donatella@kreoscapital.co.uk

			
		 	with copies to:	  	 Speechly Bircham LLP
 6 New
Street Square
 London EC4A 3LX
 United
Kingdom
 Attn: James Watts, Esq.
 Fax:
+44 (0)20-7427-6600
 Email: James.Watts@speechlys.com

			
		 	and:	  	 Sonnenschein Nath & Rosenthal LLP

2 World Financial Center
 New York, New York
10281
 Attn: Denise M. Tormey, Esq.

Fax: (212) 768-6800
 Email:
DTormey@sonnenschein.com

			
	 SILICON VALLEY BANK,

as Lender

		
	By:	 	 /s/ Kristen Parsons

	Name:	 	 Kristen Parsons

	Title:	 	 RM

  

							
	Address for notices:
		  		 		    	 Silicon Valley Bank
 Kristen
Parsons
 230 West Monroe Street, Suite 720

Chicago, Illinois 60606
 PHONE
312.704.9512
 FAX 312.704.1532

kparsons@svb.com

				
		  		 	with a copy to:	    	 Riemer & Braunstein LLP

Three Center Plaza
 Boston, Massachusetts 02108

 Attn: David A. Ephraim, Esq.
 Fax:
(617) 880-3456
 Email: DEphraim@riemerlaw.com

			
	 KREOS CAPITAL III (UK) LIMITED,

as Administrative Agent

		
	By:	 	 /s/ Maurizio Petitbon

	Name:	 	MAURIZIO PETITBON
	Title:	 	DIRECTOR

 EXHIBIT A — COLLATERAL DESCRIPTION 

The Collateral consists of all of each Credit Party’s right, title and interest in and to the following personal property:

 All goods, Accounts (including health-care receivables), Equipment, Inventory, contract rights or rights to payment of money,
leases, license agreements, franchise agreements, General Intangibles (except as provided below), commercial tort claims, documents, instruments (including any promissory notes), chattel paper (whether tangible or electronic), cash, deposit
accounts, fixtures, letters of credit rights (whether or not the letter of credit is evidenced by a writing), securities, and all other investment property, supporting obligations, and financial assets, whether now owned or hereafter acquired,
wherever located; and 
 All Books relating to the foregoing, and any and all claims, rights and interests in any of the above
and all substitutions for, additions, attachments, accessories, accessions and improvements to and replacements, products, proceeds and insurance proceeds of any or all of the foregoing. 

Notwithstanding the foregoing, the Collateral shall not include any “intent-to-use” trademarks at all times prior to the first
use thereof, whether by the actual use thereof in commerce, the recording of a statement of use with the United States Patent and Trademark Office or otherwise. 
  

 A - 1 

 EXHIBIT B — LOAN PAYMENT/ADVANCE REQUEST FORM 

 

 B - 1 

 DEADLINE FOR SAME DAY PROCESSING IS NOON EASTERN TIME 

 

			
	Fax To:	  	Date: April 1, 2010

  

							
	LOAN
PAYMENT:
	 
	
Horizon Pharma USA, Inc.
and                        (“Borrowers”)

Nitec Pharma
AG                                

	 			 
	From Account #	  	 n/a
	  	        To Account #	  	 n/a

	 	  	(Deposit Account #)	  		  	(Loan Account #)
	 			 
	Principal $	  	 n/a
	  	        and/or Interest $	  	 n/a

	 			 
	Authorized Signature:	  	  
	  	        Phone Number:	  	  

	Print Name/Title:	  	  
	  		  	 
	 	  	 	  	 	  	 

  

													
	LOAN ADVANCE:	  	 
	 	 
	Complete Outgoing Wire Request section below if all or a portion of the funds from this loan advance are
for an outgoing wire.	  	 
	 						 
	From Account #	  	 See attached Flow of Funds Memorandum
	  		  		  	To Account #	  	   See attached Flow of Funds

  Memorandum
	  	 
	 	  	(Loan Account #)	  		  		  		  	(Deposit Account #)	  	 
	 						 
	Amount of Advance $	  	 $7,000,000
	  		  		  		  		  	 
	 
	All Borrowers’ representations and warranties in the
Loan and Security Agreement are true, correct and complete in all material respects on the date of the request for an advance; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that
already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such
date:

													
	 		 
	Authorized Signature:	 		  	Horizon Pharma USA, Inc.
	 	 		  	By:	  	 /s/ Timothy P. Walbert
	  		  		  	 
	 	 		  	Its:	  		  		  		  	 
	 			 
	 	 		  	Nitec Pharma AG	  	 
	 	 		  	By:	  	 /s/ Anders Härfstrand
	  		  	 /s/ Jochen Mattis
	  	 
	 	 		  	Its:	  	CEO	  		  	Jochen Mattis EVP	  	 
	 	 		  	  
	  		  		  	 
	 	 	  
	  		  		  	 
	 	 	 	  	 	  	 	  	 	  	 	  	 

  

 B - 1 

											
	OUTGOING WIRE REQUEST:	  	 
	 Complete only if all or a portion of funds from the loan advance
above is to be wired.
 Deadline for same day processing is noon, Eastern Time
	  	 
	 					 
	Beneficiary Name:	  	 See attached Flow of Funds

Memorandum
	  		  	Amount of Wire: $	 	  
	  	 
	Beneficiary Bank:	  	  
	  		  	Account Number:  	 	  
	  	 
	City and State:	  	  
	  		  		 		  	 
	 			 
	Beneficiary Bank Transit (ABA) #:         
                                 	  		  	Beneficiary Bank Code (Swift, Sort, Chip, etc.):              
    	  	 
	 	  		  		  	 (For International Wire Only)
	  	 
	 					 
	Intermediary Bank:	  	  
	  		  	Transit (ABA) #:    	 	  
	  	 
	For Further Credit to:	  	  
	  		  		 		  	 
	 					 
	Special Instruction:	  	  
	  		  		 		  	 
	 	 
	By signing below, I (we) acknowledge and agree that my (our) funds transfer request shall be processed in
accordance with and subject to the terms and conditions set forth in the agreements(s) covering funds transfer service(s), which agreements(s) were previously received and executed by me (us).	  	 
	 					 
	Authorized Signature:	  	Horizon Pharma USA, Inc.	  		  	Authorized Signature:	 	Nitec Pharma AG	  	 
	 					 
	 	  	 By: /s/ Timothy P. Walbert
	  		  		 	 By: /s/ Anders Härfstrand
	  	 
	Print Name/Title:	  	 CEO
	  		  	Print Name/Title:	 	ANDERS HÄRFSTRAND	  	 
	Telephone #:	  	224 383 3009	  		  	Telephone #:	 	+4161 715 2040	  	 
	 	  	 	  	 	  	 	 	 	  	 

  

			
	 /s/ Jochen Mattis
	 	
	Jochen Mattis EVP	 	

  

 B - 1 

 EXHIBIT C — COMPLIANCE CERTIFICATE 

 

			
	 TO: KREOS CAPITAL III (UK) LIMITED
	  	Date:                     

FROM: HORIZON PHARMA, INC. 
 The
undersigned authorized officer of Horizon Pharma, Inc., a Delaware corporation (“Guarantor”), certifies on behalf of Guarantor and Horizon Pharma USA, Inc., a Delaware corporation (“Horizon”) and Nitec Pharma AG, a company formed
under the laws of Switzerland (“Nitec” and together with Horizon, “Borrowers”), that under the terms and conditions of the Loan and Security Agreement among Guarantor, Borrowers, Kreos Capital III (UK) Limited, as administrative
agent (“Administrative Agent”), and the Lenders party thereto from time to time (the “Agreement”): 
 (1)
Credit Parties are in complete compliance for the period ending with all required covenants except as noted below; (2) there are no Events of Default except as noted below; (3) all representations and warranties in the Agreement are true
and correct in all material respects on this date except as noted below; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the
text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date; (4) Credit Parties, and each of their
Subsidiaries, have timely filed all required Tax returns and reports or extensions therefore, and have timely paid all foreign, federal, state and local Taxes, assessments, deposits and contributions owed by them except as otherwise permitted
pursuant to the terms of Section 5.9 of the Agreement; (5) no Liens have been levied or claims made against any Credit Party or any of its Subsidiaries relating to unpaid employee payroll or benefits of which such Credit Party has
not previously provided written notification to Administrative Agent; and (6) the revenue of Nitec for the period ending
                     was $        . 

Attached are the required documents supporting the certification. The undersigned certifies that these are prepared in accordance with Applicable
Accounting Standards consistently applied from one period to the next except as explained in an accompanying letter or footnotes. The undersigned acknowledges that no borrowings may be requested at any time or date of determination that Credit
Parties are not in compliance with any of the terms of the Agreement, and that compliance is determined not just at the date this certificate is delivered. Capitalized terms used but not otherwise defined herein shall have the meanings given them in
the Agreement. 
 Please indicate compliance status by circling Yes/No under “Complies” column. 

 

					
	Reporting Covenant	  	Required	  	Complies
	Monthly Financial Statements with Compliance Certificate	  	Monthly within 30 days	  	Yes    No
	 	 	 
	Quarterly Consolidation Financial Statements	  	Quarterly within 30 days	  	Yes    No
	 	 	 
	Annual financial statement (CPA Audited)	  	FYE within 180 days	  	Yes    No
	 	 	 
	10 Q, 10 K and 8-K	  	Within 5 days after filing with SEC	  	Yes    No
	 	 	 
	Board Approved Projections	  	Annually, within 10 days of Board approval	  	Yes    No

The following are the exceptions with respect to the certification above: (If no exceptions exist, state “No exceptions to
note.”) 
  

	
	  

	  

 

									
	HORIZON PHARMA, INC.	 	 	 	LENDER USE ONLY
	 		 		 
	By:	 	  
	 		 	Received by:	 	  

	Name:	 	  
	 		 		 	AUTHORIZED SIGNER
	Title:	 	  
	 		 	Date:	 	  

	 	 		 		 	Verified:	 	  

	 	 		 		 		 	AUTHORIZED SIGNER
	 	 		 		 	Date:	 	  

	 	 	 	 	 	 	Compliance Status:
                                         
               Yes    No

  

 C - 1Agreement for the Provision of a Loan Facility

 Exhibit 10.6 

Execution Version 

AGREEMENT FOR THE PROVISION OF A LOAN FACILITY 

OF UP TO EURO 7,500,000 

Date 15/8/2008 

Between 
 KREOS CAPITAL III
(UK) LIMITED a company incorporated in the England and Wales whose company number is 05981165 and whose registered office is at Cardinal House, 39/40 Albemarle Street, London W1S 4TE (the “Lender, which expression shall include its
successors and assigns); 
 and 

NITEC PHARMA AG, a company incorporated in Switzerland with number CH-280.3.007.771-0/ whose registered office is at Kägenstrasse 17, CH-4153
Reinach, Switzerland (the “Borrower”). 
 WHEREAS: 

 

	1.	The Borrower wishes to borrow up to the Total Loan Facility (as defined below) and the Lender wishes to make the Total Loan Facility available to the Borrower on
the terms of this Loan Agreement. 

  

	2.	The Borrower hereby confirms that it shall grant a debenture over the Borrower’s undertaking and assets to the Lender as security for monies borrowed by the
Borrower hereunder. 

 LOAN FACILITY TERMS: 

 

			
	Total Loan Facility	  	 Euro 7,500,000 is available in two tranches, as follows:

 
 Euro 4,000,000 on or about 15 September 2008 (“Tranche 1”) upon
re-activation by the relevant European healthcare authorities of the Decentralized Procedure in respect of the Borrower’s most advanced product, Lodotra (so-called “Day 106”)

 
 Euro 3,500,000 on 1 February 2009 (“Tranche
2”)

		
	Date of Expiry of Loan Facility	  	The Loan Facility will be available for Drawdown up to 2 October 2008
		
	Advance Payment	  	3.285% of the Total Loan Facility
		
	Loan Term	  	36 months in respect of each Drawdown
		
	Transaction Fee	  	Euros 75,000 (representing 1% of the Total Loan Facility) payable on the date of first Drawdown (Tranche 1)
		
	End of Loan Payment	  	Euros 56,250 (representing 0.75% of the Total Loan Facility) (Tranche 2)
		
	Minimum Drawdown Amount	  	Euros 2,500,000

  

 1. 

 Execution Version 

 

	1.	DEFINITIONS 

 In this Loan Agreement,
including the recitals set out above, unless otherwise defined: 
  

	1.1	“Accounts” means the audited annual consolidated profit and loss account and balance sheet of the Borrower and its subsidiaries for the period ended on
[31st December [2007]. 

  

	1.2	“Advance Payment” has the meaning given in Clause 5.1 and is in the amount set forth above in the Loan Facility Terms. 

 

	1.3	“Affiliate” means any Group Company and any duly appointed portfolio manager of any Group Company. 

 

	1.4	“Applicable Interest Rate” has the meaning given in Clause 6.1. 

 

	1.5	“Assignee” has the meaning given in Clause 14.5. 

  

	1.6	“Business Day” means any day on which banks are generally open for business in London other than a Saturday or Sunday. 

 

	1.7	“Charged Assets” means the assets and undertaking charged or to be charged to the Lender from time to time pursuant to the Security Documents.

  

	1.8	“Contractual Currency” has the meaning given to it in Clause 5.3. 

 

	1.9	“Date of Expiry of the Loan Facility” means the date set forth above under the heading Loan Facility Terms. 

 

	1.10	“Drawdown” means each or any of Tranche 1 or Tranche 2. 

  

	1.11	“Drawdown Date” means, unless otherwise provided herein, the date on which the Loan (or relevant portion thereof) is actually advanced to the Borrower
by the Lender. 

  

	1.12	“Drawdown Notice” means a drawdown notice served in accordance with Clause 3.2 in the form attached hereto as Schedule B (as may be amended with the
prior written consent of the Lender). 

  

	1.13	“Event of Default” means any of the events or circumstances described in Clause 9. 

 

	1.14	“EURIBOR” means the average interbank deposit rate for an interest period of three months, offered in the Economic and Monetary Union Zone by prime
banks as published by Reuters. 

  

	1.15	“Financial Indebtedness” means (i) monies borrowed, (ii) finance or capital leases, (iii) receivables sold or discounted (other than on
a non-recourse basis), (iv) other transactions having the commercial effect of borrowing, (v) the market to market value of derivative transactions entered into in connection with protection against or benefit from fluctuation in any rate
or price, (vi) counter-indemnity obligations in respect of guarantees or other instruments issued by a bank or financial institution, and (vii) liabilities under guarantees or indemnities for any of the obligations referred to in items
(i) to (vi). 

  

	1.16	“Group” means the Borrower and its subsidiaries (if any) and any holding company of the Borrower and subsidiaries of any such holding companies from
time to time and “Group Company” means any member of the Group. 

 

	1.17	“Intellectual Property” means copyrights and related rights (including, without limitation, rights in computer software), patents, supplementary
protection certificates, utility models, trade marks, trade names, service marks, domain name registrations, registered and unregistered rights in designs, database rights, semi-conductor topography rights, plant variety rights, rights protectable
by the law of passing off or by laws against unfair competition, rights in undisclosed or confidential information (such as know how, trade secrets and inventions (whether patentable or not)), and other similar intellectual property rights (whether
registered or not) and applications for such rights as may exist anywhere in the world; 

  

	1.18	“Interim Repayment” means the payment in respect of the period from each Drawdown Date to the first Business Day of the calendar month following the
relevant Drawdown Date calculated by dividing the monthly repayment amount (principal and interest) for that Drawdown by the number of days in the month that the Drawdown is made and multiplying that figure by the number of days between (and
including) the Drawdown Date and the first Business Day of the following calendar month. 

  

	1.19	“Loan” means the loan to be made in accordance with the terms of this Loan Agreement. 

 

	1.20	“Loan Facility” means the loan facility granted by this Loan Agreement. 

 

	1.21	“Loan Term” means 36 months commencing on the relevant Drawdown Date or, if such day is not a Business Day, the first Business Day thereafter.

  

	1.22	“Pledge Agreement” means the pledge agreement over the Borrower’s intellectual property rights securing the Borrower’s obligations towards
the Lender under this Loan Agreement. 

  

	1.23	“Receivables Assignment Agreement” means the assignment by the Borrower of its trade receivables in favour of the Lender as security for its
obligations under this Loan Agreement. 

  

	1.24	“Security Documents” means (i) the assignment by the Borrower to the Lender of its trade receivables under the Receivables Assignment Agreement,
and (ii) the pledge granted by the Borrower in favour of the Lender over its intellectual property rights under the Pledge Agreement. 

  

	1.25	“Security Interest” means any mortgage, charge (whether fixed or floating, legal or equitable), pledge, lien, hypothecation, assignment by way of
security or otherwise, trust arrangement, title retention or encumbrance or enforceable right of a third party, any other type of security interest or preferential arrangement having a similar effect to any of the foregoing or in the nature of
security of any kind whatsoever; 

  

	1.26	 “Security Period” means the period commencing on the Drawdown Date and

  

 2. 

 Execution Version 

 

	 	 
ending on the date on which all amounts due and payable by the Borrower under this Loan Agreement and the Security Documents have been repaid. 

 

	1.27	“Taxes” means all present and future income, value added and other taxes, levies, imposts, deductions, charges and withholdings in the nature of taxes
(other than taxes on the profits of the Lender) whatsoever together with interest thereon and penalties with respect thereto made on or in respect thereof. 

 

	1.28	“Total Loan Facility” means the amount set forth above under the heading Loan Facility Terms. 

 

	1.29	“Transaction Fee” has the meaning given in Clause 10.1 and is the amount set forth above in the Loan Facility Terms. 

 

	1.30	“Warrant” means a warrant to purchase shares in the capital of the Borrower in the form agreed by the Lender and the Borrower.

  

	2.	INTERPRETATION 

 In this Loan Agreement
(unless the context requires otherwise) any reference to: 
  

	2.1	any law or legislative provision includes a reference to any subordinate legislation made under that law or legislative provision before the date of this Loan
Agreement, to any modification, re-enactment or extension of that law or legislative provision made before that date and to any former law or legislative provision which it consolidated or re-enacted before that date; 

 

	2.2	any gender includes a reference to other genders and the singular includes a reference to the plural and vice versa; 

 

	2.3	a Clause or Schedule is to a Clause or Schedule (as the case may be) of or to this Loan Agreement; 

 

	2.4	a person shall be construed as including a reference to an individual, firm, company, corporation, unincorporated body of persons or any country or state thereof or any
agency thereof; 

  

	2.5	an “amendment” includes a supplement, novation or re-enactment in writing and “amended” is to be construed accordingly; 

 

	2.6	“assets” includes present and future properties, undertakings, revenues, rights and benefits of every description; 

 

	2.7	An “authorisation” includes an authorisation, consent, approval, resolution, licence, exemption, filing, registration and notarisation;

  

	2.8	a “regulation” includes any regulation, rule, official directive, request or guideline (whether or not having the force of law) of any governmental,
inter-governmental or supranational body, agency, department or regulatory, self-regulatory or other authority or organisation; 

  

	2.9	“control” shall bear the meaning set out in Section 416 Income and Corporation Taxes Act 1988; 

 

	2.10	“controlling interest” shall be construed accordingly; 

 

	2.11	“holding company” means a parent undertaking within the meaning of Section 1159 of the Companies Act 2006; 

 

	2.12	“subsidiary” means a subsidiary company within the meaning of Section 1159 of the Companies Act 2006; 

 

	2.13	(or to any specified provision of) this or the Loan Agreement, a provision of any other document shall be construed as a reference to this Loan Agreement, that
provision or that document as in force for the time being and as amended in accordance with the terms thereof, or, as the case may be, with the agreement of the relevant parties and (where such consent is, by the terms of this Loan Agreement or the
relevant document, required to be obtained as a condition to such amendment being permitted) the prior written consent of the Lender; and 

  

	2.14	“other” and “otherwise” are not to be construed eiusdem generis with any foregoing words where a wider construction is possible and
“including” and “in particular” are to be construed as being by way of illustration or emphasis only and are not to be construed as, nor shall they take effect as, limiting the generality of any foregoing words.

 The headings in this Loan Agreement are inserted for convenience only and do not form part of this Loan Agreement and do not
affect its interpretation. 
  

	3.	LOAN FACILITY 

  

	3.1	Lender’s Commitment 

  

	3.1.1	Subject to Clause 3.5 below, the Lender shall and agrees hereby to make available to the Borrower the Total Loan Facility under the terms of this Loan Agreement.

  

	3.1.2	The Lender shall not be under any commitment to advance the Loan or any part thereof after the Date of Expiry of the Loan Facility or upon the earlier termination of
the Loan Facility in accordance with Clause 3.4 or on any dates other than those specified in the Loan Facility Terms. 

  

	3.1.3	The unutilised portion (if any) of the Loan Facility shall be cancelled after the Date of Expiry of the Loan Facility, whereupon the Total Loan Facility shall be
reduced accordingly. 

  

	3.1.4	In granting the Loan Facility the Lender is relying on the representations and warranties contained in Clause 7. 

 

	3.1.5	Each Drawdown made under the Loan Facility shall be secured by the Security Documents. 

 

	3.2	Date of Advance of the Loan 

Subject to Clause 3.1.2, (and subject to the satisfaction of the relevant conditions set forth in Clause 3.5); each Drawdown shall be
advanced and made available to the Borrower within fifteen Business Days from receipt by the Lender of an executed Drawdown Notice. Each Drawdown Notice shall constitute a separate and independent obligation of the Borrower incorporating the terms
of this Loan Agreement. 

  

 3. 

 Execution Version 

 

	3.3	Method of Disbursement 

The payment by the Lender to the account specified in the Drawdown Notice shall constitute the making of the Loan (or the relevant part
thereof) and the Borrower shall thereupon become indebted, as principal and direct obligor, to the Lender in an amount equal to the Loan (or the relevant part thereof). 

 

	3.4	Termination or Modification of funding commitment 

The Lender’s commitment to advance the Loan until and including the Date of Expiry of the Loan Facility in accordance with the
terms of this Loan Agreement is limited in aggregate to the amount of the Total Loan Facility; provided, however, that the Lender, acting in its sole discretion, may terminate or modify its funding commitment pursuant to this Loan Agreement at any
time if: 
  

	3.4.1	there is, in the Lender’s reasonable opinion, any material adverse change in the general affairs, business, management, results of operations, condition (financial
or otherwise) or prospects of the Group whether or not arising from transactions in the ordinary course of business; 

  

	3.4.2	there is, in the Lender’s reasonable opinion, any accelerated depreciation in the value of the Charged Assets; 

 

	3.4.3	there is, in the Lender’s reasonable opinion, any material adverse deviation by the Borrower from its business plan (as it may have been supplemented in writing
with the prior consent of the Lender) presented to the Lender prior to the date of this Loan Agreement,; 

  

	3.4.4	on either the date of the Drawdown Notice or at the Drawdown Date: 

  

	 	(i)	an Event of Default has occurred or would result from the borrowing to be made pursuant to the Drawdown Notice; or 

 

	 	(ii)	the Borrower’s representations and warranties in Clause 7.1 or those which are set out in any Security Documents would not be true if repeated on each of those
dates with reference to the circumstances then existing. 

  

	3.5	Conditions Precedent requirements relative to the advance of the Loan 

The Lender’s obligation to provide the Loan (or any part thereof) is subject to the prior satisfaction by the Borrower of the
following conditions: 
  

	 	(i)	the provision of a certified copy of the resolutions of the Borrower’s board of directors (and, if relevant, its subsidiaries) and, to the extent required,
shareholders, authorising the transactions contemplated by this Loan Agreement and the execution and delivery to the Lender of this Loan Agreement and associated documents, including but not limited to, the Security Documents;

 

	 	(ii)	certified copies of the Certificate of Incorporation and the Memorandum and Articles of Association of the Borrower; 

 

	 	(iii)	all necessary consents of shareholders, warrant holders, and other third parties (including landlords) with respect to the entering into of this Loan Agreement and the
execution of associated documents, including but not limited to, any Security Documents, have been obtained; 

  

	 	(iv)	a certificate of a director of the Borrower confirming that the borrowing of the Loan Facility in full would not cause any borrowing limit binding on the Borrower to be
exceeded; 

  

	 	(v)	specimen signatures, authenticated by a director or the company secretary of the Borrower, of the persons authorised in the resolutions of the board of directors
referred to in Clause 3.5(i); 

  

	 	(vi)	the parties having executed and delivered to the Lender the originals of the Security Documents; 

 

	 	(vii)	in the Lender’s reasonable opinion, there has been no accelerated depreciation in value of the Charged Assets; 

 

	 	(viii)	delivery by the Borrower to the Lender of such documentation in a form and substance satisfactory to the Lender as the Lender may reasonably request with respect to
invoices, purchase orders and the like relating to future Charged Assets purchases to be subject to this Loan Agreement and/or any Security Documents; 

  

	 	(ix)	the Borrower’s compliance with Clauses 10.1, 10.2 and reasonable evidence of the Borrower’s compliance with Clause 12.2.3 below; 

 

	 	(x)	the financial model and forecasts for the Group as requested by the Lender; 

 

	 	(xi)	the most recent management accounts of the Borrower (and the Group); 

  

	 	(xii)	any such other documentation in form and substance satisfactory to the Lender as the Lender may reasonably request; 

 

	 	(xiii)	confirmation that the Charged Assets are free and clear of all Security interests whatsoever; 

 

	 	(xiv)	the Borrower- having issued to Kreos Capital III Limited the Warrant; and 

  

	 	(xv)	evidence, to the reasonable satisfaction of the Lender, of the reactivation by the relevant European healthcare authorities of the Decentralised Procedure in respect of
the approval of Lodotra (so-called “Day 106”). 

 each copy document delivered under this Clause 3.5
shall be certified as a true and up to date copy by a director or the company secretary of the Borrower. 

  

 4. 

 Execution Version 

 

	3.6	Waiver Possibility 

 If
the Lender advances all or any part of the Loan to the Borrower prior to the satisfaction of all or any of the conditions referred to in Clause 3.5 (which the Lender has no obligation to do) the Borrower shall satisfy or procure the satisfaction of
such condition or conditions which have not been satisfied within fourteen (14) Business Days of the Drawdown Date (or within such longer period as the Lender may agree or specify), provided, that the Lender at its discretion may waive the
satisfaction of any condition. 
  

	3.7	Charged Assets 

  

	3.7.1	Unless the Lender shall otherwise agree in writing, the Borrower shall use the Loan solely for the purpose of general working capital in accordance with Clause 3.7.2.
Without prejudice to Clause 3.7.2 the Lender shall not be under any obligation to concern itself with the application of the Loan. 

  

	3.7.2	The Charged Assets shall form the security for the monies borrowed by the Borrower. 

 

	3.7.3	Upon the loan being discharged in full and the Lender under no further obligation to make any financial accommodation or loan facility to the Borrower under this Loan
Agreement or upon the listing of the Borrowers securities with an internationally recognized stock exchange, such as SWX Swiss Exchange (provided that listing raises at least 24 months of working capital for the Borrower from the date of funding and
the Borrower grants to the Lender a negative pledge over the Intellectual Property of the Borrower) the Charged Assets shall be released to the Borrower or such other Party as designated by the Borrower. 

 

	4.	TERM 

  

	4.1	This Loan Agreement is effective upon execution by the Lender and the Borrower and shall continue until the later of (i) Date of Expiry of the Loan Facility and
(ii) the date upon which the Borrower shall have performed all its obligations hereunder. 

  

	4.2	If the conditions set out in Clause 3.5 have not been satisfied within forty-five (45) days of the execution of this Loan Agreement (except to the extent waived in
writing by Lender), the Lender shall in its sole discretion have the option to either terminate the Loan Agreement or extend the period in which such conditions must be satisfied. 

 

	5.	REPAYMENT AND PREPAYMENT 

  

	5.1	Advance Payment 

 On
delivery of the first Drawdown Notice with respect to the Loan, the Borrower shall pay to the Lender (by way of deduction by the Lender from the amount of the Loan actually advanced to the Borrower) the Advance Payment specified above in the Loan
Facility Terms, which shall be held by the Lender and applied in or towards the final payment(s) under this Loan Agreement. 

 

	5.2	Repayments 

 The
Borrower shall repay the amount drawn down under each Drawdown in 36 monthly payments (of principal and interest), each such payment in an amount of 3.483% (subject to any upward adjustment in accordance with Clause 6.3) of the amount drawn down, to
be paid to the Lender on the first Business Day of the 36 calendar months. Any amount repaid or prepaid may not be redrawn. 
  

	5.2.1	If the Drawdown Date is not the first Business Day of a calendar month, the Borrower shall pay to the Lender on the Drawdown Date (by way of deduction by the Lender of
the amount of the Loan actually advanced to the Borrower) the Interim Repayment. 

  

	5.3	Currency of Payments 

Repayment of the Loan and payment of all other amounts owed to the Lender will be paid in the currency in which the Loan has been
provided (the “Contractual Currency”), unless otherwise agreed by the parties in writing. The Borrower shall bear the cost in the event of and in respect of any conversion of a currency to the Contractual Currency. 

 

	5.4	Prepayments 

  

	5.4.1	The Borrower shall be entitled to prepay the amount of all Drawdowns under the Loan, in whole or in part, subject to the following conditions: 

 

	 	(i)	the Borrower shall submit to the Lender an irrevocable written request to prepay the Loan (or part of the Loan), at least fifteen (15) Business Days in advance,
indicating the amount to be prepaid and the date of prepayment. Such 15 Business Day period shall be reduced to a 10-day period where the circumstances set out in clause 10.6.2 below prevail. 

 

	 	(ii)	if the prepayment is for the whole of the Loan the prepayment sum shall be equal to the aggregate sum of all monthly payments of principal and interest (as set forth in
Clause 5.2 above), which would but for the prepayment have been paid throughout the remainder of the Loan Term (and which shall be net of the applicable Advance Payment), discounted to present value at the annual rate of 4.5%.

  

	 	(iii)	if the prepayment is for part only of the Loan the prepayment sum shall be applied to such part of the Loan representing principal and interest discounted at an annual
rate of 4.5% equal to the prepayment amount. 

  

	 	(iv)	 the minimum amount that may be prepaid if the prepayment is

  

 5. 

 Execution Version 

 
  

	 	 
for part only of the Loan shall be £500,000. 

  

	5.4.2	Any prepayment will be made together with (a) accrued interest to the date of prepayment (b) any additional amount payable under clause 10 and (c) all
other sums payable by the Borrower to the Lender under this Loan Agreement. 

  

	6.	INTEREST 

  

	6.1	Subject to Clause 6.3, Interest on the drawn down amount shall accrue from day to day at a rate of 11.9% per annum (and be compounded on a monthly basis) (the
“Applicable Interest Rate”), from the Drawdown Date until the repayment in full of the Loan, with payment of the interest being made to the Lender after any tax deduction at source including without limitation any withholding tax,
if required under applicable law. Interest on the Loan and each part thereof shall be calculated and paid in the Contractual Currency. 

  

	6.2	Time of payment of any sum due from the Borrower is of the essence under this Loan Agreement. If the Borrower fails to pay any sum to the Lender on its due date for
payment the Borrower shall pay to the Lender forthwith on demand interest on such sum (compounded on a monthly basis) from the due date to the date of actual payment (as well after as before judgment) at a rate equal to the Applicable Interest Rate
plus 5% per annum. If the Borrower fails to pay any sum within five (5) Business days after such sum is due, the Borrower shall pay to the Lender a one-off late payment charge of 3% of such sum to compensate the Lender for additional
administrative expense. 

  

	6.3	In the event that EURIBOR increases by more than 25 basis points between the date of this Loan Agreement and any Drawdown Date, the Lender may increase the Applicable
Interest Rate in line with any such increase and the payments due under Clause 5.2.1 shall be increased accordingly. 

  

	7.	REPRESENTATIONS AND WARRANTIES 

  

	7.1	The Borrower warrants and represents the following as at the date hereof: 

  

	7.1.1	the Borrower is a limited company pursuant to Art. 620 ff. of the Swiss Code of Obligations and is duly organised and validly existing under the laws of Switzerland;

  

	7.1.2	the Borrower has the corporate capacity, and has taken all corporate action and obtained all consents, including third party consents, necessary for it:

  

	 	(i)	to execute this Loan Agreement and the Security Documents to which the Borrower is or is to be party; 

 

	 	(ii)	to borrow under this Loan Agreement and to make all the payments contemplated by, and to comply with all its other obligations under this Loan Agreement and the
Security Documents; and 

  

	 	(iii)	to grant security to the Lender by way of a trade receivables assignment and a pledge over its intellectual property rights under the Security Documents;

 

	7.1.3	this Loan Agreement and the Security Documents to which the Borrower is or is to be party, do now or, as the case may be, will, upon execution and delivery (and, where
applicable, registration as provided for in this Loan Agreement and the Security Documents): 

  

	 	(i)	constitute the Borrower’s legal, valid and binding obligations enforceable against the Borrower in accordance with their respective terms; and

  

	 	(ii)	create legal, valid and binding security interests enforceable in accordance with their respective terms, subject to any relevant insolvency laws affecting
creditors’ rights generally; 

  

	7.1.4	the execution and (where applicable) registration by the Borrower of this Loan Agreement and each Security Document to which it is or is to be party, and the borrowing
by the Borrower of the Loan and its compliance with this Loan Agreement and each Security Document to which it is or is to be party will not involve or lead to a contravention of: 

 

	 	(i)	any applicable law or other legal requirement; or 

  

	 	(ii)	the constitutional documents of the Borrower; or 

  

	 	(iii)	any contractual or other obligation or restriction which is binding on the Borrower or any of its assets; 

 

	7.1.5	all consents, licences, approvals and authorisations required by the Borrower in connection with the entry into, performance, validity and enforceability of this Loan
Agreement and the Security Documents to which it is or is to be party have been or (upon execution thereof) shall have been obtained by the Drawdown Date and are (or upon execution thereof shall be) in full force and effect during the life of this
Loan Agreement; 

  

	7.1.6	all financial and other information furnished by or on behalf of the Borrower in connection with the negotiation of this Loan Agreement and the Security Documents
delivered to the Lender pursuant to this Loan Agreement or the Security Documents was true and accurate in all material respects when given and there are no other facts or matters the omission of which would have made any statement or information
contained therein misleading in any material respect; 

  

	7.1.7	the Accounts were prepared in accordance with accounting principles and practices generally accepted in Switzerland and consistently applied and fairly represent (in
conjunction with the notes thereto) the financial condition of it as at the date to which they were drawn up and the results of its operations during the financial year then ended; 

 

	7.1.8	since publication of the Accounts, there has been no material adverse change in the business or financial condition of the Borrower and/or any of its subsidiaries;

  

 6. 

 Execution Version 

 

	7.1.9	all payments made or to be made by the Borrower under or pursuant to this Loan Agreement and the Security Documents to which the Borrower is or is to be party shall be
made following deduction or withholding for, or on account of, any taxes for which withholding is required pursuant to applicable law and/or tax ruling of the applicable tax authorities; 

 

	7.1.10	there is no action, proceeding or claim pending or, so far as the Borrower is aware or ought reasonably to be aware, threatened against any Group Company before any
court or administrative agency which might have a material adverse affect on the business, condition of operations of the Borrower or any Group Company; 

  

	7.1.11	the Borrower owns with good and marketable title all the Charged Assets, free from all security interests and other interests and rights of every kind, and all the
Charged Assets are in good operating condition and repair, and are adequate for the uses to which they are being put, and none of such Charged Assets are in need of maintenance or repairs except for ordinary, routine maintenance and repairs that are
not material in nature or cost; and 

  

	7.1.12	the Borrower’s representation and warranties set out in this Clause 7 shall survive the execution of this Loan Agreement and shall be deemed to be repeated on each
Drawdown Date and each date of repayment with respect to the facts and circumstances then existing, as if made at such time. 

  

	8.	UNDERTAKINGS 

  

	8.1.1	The Borrower undertakes to the Lender to comply with the following provisions of this Clause 8 at all times during the Security Period, except as the Lender may
otherwise permit: 

  

	8.1.2	the Borrower will obtain, effect and keep effective all permissions, licences and permits which may from time to time be required in connection with the Charged Assets;

  

	8.1.3	the Borrower will own only for its own account the Charged Assets free from all security interests and other interests and rights of every kind, except for those
created by the Security Documents; 

  

	8.1.4	save as set out in clause 8.1.22 and 8.1.23, the Borrower will not sell, assign, transfer or otherwise dispose of the Charged Assets or any share therein and shall give
immediate notice to the Lender of any judicial process or encumbrance affecting the Charged Assets; 

  

	8.1.5	the Borrower will provide to the Lender such information as the Lender may reasonably request concerning the Borrower and its affairs (including concerning the Charged
Assets); 

  

	8.1.6	the Borrower will provide the Lender with its quarterly management accounts and any Group management accounts, certified by the Borrower’s managing director or
finance director as fairly presenting the data reflected, at the same time as the management accounts are provided to the board of directors of the Company (to include notification of the commencement of litigation by or against the Borrower) and,
following an initial

	 	 
public offering or listing on a recognised stock exchange, provide copies of any announcement which is proposed to be made public by the Borrower (or any Group Company) concerning dividends,
annual or interim financial positions and affairs of the Borrower (or any Group Company), and copies of any other documents required to be filed with applicable statutory or regulatory authorities or agencies in relation to the activities of the
Borrower (or any Group Company); 

  

	8.1.7	the Borrower will provide the Lender with annual audited financial statements for each Group Company at the same time as the statements are provided to the shareholders
of the Company, in each case including statement of operations, balance sheet, statement of cash flows and shareholders’ equity, certified by a firm of chartered accountants of recognised national standing; 

 

	8.1.8	the Borrower will, no later than before the start of each financial year, provide a budget showing a projected consolidated balance sheet as of the end of each
financial year, a projected profit and loss account, and a cash flow forecast for the forthcoming financial year; 

  

	8.1.9	the Borrower will provide the Lender with copies of all notices, minutes, consents and other material that it provides to its board of directors at the same time they
are delivered to the directors; 

  

	8.1.10	the Borrower will provide the Lender with all documents dispatched by the Borrower to its shareholders, or its creditors generally at the same time as they are
dispatched; 

  

	8.1.11	the Borrower will grant the Lender the right to have a representative to meet with the Borrower’s managing director and finance director once each quarter
throughout the Security Period to review and discuss the operating performance and financial condition of the Borrower. In addition, upon the occurrence of a default, the Lender shall be entitled to have a representative to attend all meetings of
the Borrower’s board of directors in a non-voting observer capacity. The Borrower agrees to give notice of all board meetings to the Lender at the same time as to its directors; 

 

	8.1.12	the Borrower will maintain in force and promptly obtain or renew, and will promptly send certified copies to the Lender of, all consents required:

  

	 	(i)	for the Borrower to perform its obligations under this Loan Agreement and each Security Document; 

 

	 	(ii)	for the validity or enforceability of this Loan Agreement and any Security Documents; and 

 

	 	(iii)	for the Borrower to continue to own the Charged Assets, 

and the Borrower will comply with the terms of all such consents; 

 

	8.1.13	the Borrower will notify the Lender as soon as it becomes aware of: 

  

	 	(i)	the occurrence of an Event of Default; or 

  

 7. 

 Execution Version 

 

	 	(ii)	any matter which indicates that an Event of Default has occurred, may have occurred or is likely to occur in the foreseeable future, 

and will thereafter keep the Lender fully up to date with all developments; 

 

	8.1.14	the Borrower will (and shall ensure that each Group Company will) maintain adequate risk protection through insurances on and in relation to its business and assets to
the extent reasonably required on the basis of good business practice taking into account, inter alia, its (and any Group Company’s) financial position and nature of operations. All insurances must be with reputable independent insurance
companies or underwriters; 

  

	8.1.15	the Borrower shall not (and shall ensure that no Group Company will) incur or allow to remain outstanding any Financial Indebtedness, except: 

 

	8.1.15.1	under this Loan Agreement; 

  

	8.1.15.2	non-speculative hedging transactions entered into in the ordinary course of business in connection with protection against interest rate or currency fluctuations; or

  

	8.1.15.3	arising in the ordinary course of business with suppliers of goods with a maximum duration of 90 days; 

 

	8.1.16	the Borrower shall not (and shall ensure that no Group Company will) incur or allow to remain outstanding any Financial Indebtedness owing to any shareholder of a Group
Company (excluding other Group Companies) or any persons or companies related to them, unless such Financial Indebtedness is on terms (including interest, repayment and subordination) satisfactory to the Lenders; 

 

	8.1.17	the Borrower shall not (and shall ensure that no other Group Company will) create or permit to subsist any Security over any of its assets; 

 

	8.1.18	the Borrower shall not (and shall ensure that no other Group Company will): 

 

	8.1.18.1	sell, transfer or otherwise dispose of any of its assets on terms whereby they are leased to or intended to be re-acquired by any Group Company;

  

	8.1.18.2	sell, transfer or otherwise dispose of any of its receivables on recourse terms; 

 

	8.1.18.3	enter into any arrangement under which money or the benefit of a bank or other account may be applied, set-off or made subject to a combination of accounts; or

  

	8.1.18.4	enter into any other preferential arrangement having a similar effect, in circumstances where the arrangement or transaction is entered into primarily as a method of
raising Financial Indebtedness or of financing the acquisition of an asset; 

	8.1.19	Clauses 8.1.17 and 8.1.18 do not apply to: 

  

	8.1.19.1	Security provided to the Lender under the Loan Agreement or any Security Document 

 

	8.1.19.2	any netting or set-off arrangement entered into by any Group Company in the ordinary course of its banking arrangements for the purpose of netting debit and credit
balances; and 

  

	8.1.19.3	any lien arising by operation of law and in the ordinary course of trading; 

  

	8.1.19.4	Clauses 8.1.3, 8.1.4, 8.1.17 and 8.1.18 do not apply to non-exclusive or exclusive licenses granted by the Borrower to a Group Company or a third party over any of its
Intellectual Property rights provided that such licences are granted for full market value. 

  

	8.1.20	the Borrower will not make any distribution by way of dividend or otherwise without the prior written consent of the Lender. 

 

	8.1.21	The Borrower shall be responsible for all costs associated with the Charged Assets including all tax assessments, insurance premiums, operating costs and repair and
maintenance costs [as well as any fees associated with registering of any security granted in connection with this Loan]. 

  

	8.1.22	Without prejudice to clause 8.1.23, in the event that the Borrower intends to dispose of some of its Charged Assets (where such disposal would not constitute a change
of control, as defined in clause 9.1.12), it shall notify the Lender of the full details of the proposed disposal and shall not undertake any such disposal unless and until the Lender approves such disposal in writing (such approval not to be
unreasonably withheld). 

  

	8.1.23	In the event that the Borrower disposes of any Charged Assets and such disposal constitutes a change of control, as defined in clause 9.1.12, then, the Loan, all
accrued interest and all other amounts accrued or owing from the Borrower under this Loan Agreement and the Security Documents shall become immediately due and payable (and the parties agree that, provided that payment to the Lender takes place on
the same day as the disposal, such payment shall constitute immediate payment). 

  

	8.1.24	In respect of any disposal under clause 8.1.23, the Lender shall use its reasonable endeavours in arranging the mechanics of the release of security over the Charged
Assets to facilitate the disposal. 

  

	9.	EVENTS OF DEFAULT 

  

	9.1	An Event of Default occurs if: 

  

	9.1.1	the conditions set out in Clause 3.5 are not satisfactorily accomplished within forty five (45) days of signature of this Loan Agreement unless the period for
satisfactory accomplishment is extended pursuant to and in accordance with Clause 4.2; or 

  

	9.1.2	the Borrower fails to pay when due and payable or (if so payable) on demand any sum payable under this Loan Agreement or the Security Documents or under any document
relating to the Security Documents; provided however that such failure to pay shall not constitute an Event of Default if such failure has been rectified within five (5) Business Days after the Lender has advised the Borrower of such
non-payment; or 

  

	9.1.3	any other breach by the Borrower occurs of any material provision of this Loan Agreement or the Security Documents (other than a breach covered by Clause 9.1.2 above)
unless: 

  

	 	(i)	 the Lender notifies the Borrower in writing that it is satisfied that

  

 8. 

 Execution Version 

 
  

	 	 
the breach has not put any of the Security for the Loan immediately at risk and that it considers that the breach is capable of remedy; and 

 

	 	(ii)	within fifteen (15) Business Days after the Lender serves on the Borrower a notice of default under this Loan Agreement, or such longer period as the Lender may
specify in such notice, the Borrower remedies the breach to the satisfaction of the Lender; or 

  

	9.1.4	any representation, warranty or statement made by, or by an officer of, the Borrower in this Loan Agreement or the Security Documents or in the Drawdown Notice or any
other notice or document relating to this Loan Agreement or any other Security Document is untrue or misleading in any material respect when it is made or deemed repeated; or 

 

	9.1.5	financial indebtedness of the Borrower in an amount which may reasonably be considered to be material is not paid when due as a consequence of a default with respect
thereto or any security interest over any assets of the Borrower is lawfully enforced; or 

  

	9.1.6	any order shall be made by any competent court or any resolution shall be passed by the Borrower for a composition proceedings pursuant to Art. 293 ff. on the Swiss Law
on Debt Enforcement and Bankruptcy Law; or 

  

	9.1.7	any order shall be made by any competent court or any resolution shall be passed by the Borrower for the appointment of a liquidator, administrator or receiver of, or
for the winding up of, the Borrower; or 

  

	9.1.8	an encumbrancer takes possession of or a receiver is appointed over the whole or, in the opinion of the Lender, any material part of, the assets of the Borrower or a
distress, execution or other process is levied or enforced upon or sued out against the whole or, in the opinion of the Lender, a material part of the assets of the Borrower; or 

 

	9.1.9	the Borrower shall stop payment or shall be unable to, or shall admit inability to, pay its debts as they fall due, or shall be adjudicated or found bankrupt or
insolvent, or shall enter into any composition or other arrangement with its creditors generally; or 

  

	9.1.10	any event shall occur which under the law of any jurisdiction to which the Borrower is subject has an effect equivalent or similar to any of the events referred to in
Clause 9.1.6, 9.1.7 or 9.1.8; or 

  

	9.1.11	the Borrower ceases or suspends carrying on its business or a part of its business which, in the reasonable opinion of the Lender, is material in the context of this
Loan Agreement and the Security Documents; or 

  

	9.1.12	there is a change of control in the Borrower; for purposes of this Clause 9.1.11, a “change of control” shall mean any of the following events (whether in one
or in a series of related transactions): merger, consolidation, or reorganisation of the Borrower with or into, or the sale of all or substantially all the assets of the

	 	 
Borrower, or the sale or issue of shares or securities of the Borrower (whether by the Borrower or by shareholders of the Borrower) representing a majority of the voting power in the Borrower, or
the exclusive license of all or a material portion of the Borrower’s intellectual property, to, any other entity or person, other than a wholly-owned subsidiary of the Borrower; provided, that the Lender may agree, by written notice to the
Borrower, that a change of control shall not be deemed an Event of Default, but that nevertheless the consequences set forth in Clause 9.2.1 and 9.2.2 shall apply, and in such event the Loan, all accrued interest and all other amounts accrued or
owing under this Loan Agreement and the Security Documents shall be due and payable simultaneously with the closing of the change of control transaction; (for the avoidance of doubt, any merger, consolidation, or reorganisation shall only be deemed
a change of control if (i) securities representing more than fifty (50) percent of the total combined voting power of the Borrower’s outstanding securities are transferred to a person or persons different from the persons holding
those securities immediately prior to such transaction; and (ii) the person or persons acquiring the securities did not have fifty (50) percent of the total combined voting power already prior to such transaction); or

  

	9.1.13	it becomes unlawful or impossible (i) for the Borrower to discharge any liability under this Loan Agreement or to comply with any other obligation which the Lender
considers material under this Loan Agreement or the Security Documents, or (ii) for the Lender to exercise or enforce any right under, or to enforce any security interest created by, this Loan Agreement or the Security Documents; or

  

	9.1.14	any provision which the Lender reasonably considers material of this Loan Agreement or the Security Documents proves to have been or becomes invalid or unenforceable,
or a security interest created by the Security Documents proves to have been or becomes invalid or unenforceable or such a security interest proves to have ranked after, or loses its priority to, another security interest or any other third party
claim or interest, provided however that if the Borrower proposes replacement security which the Lender may not refuse without reason, and such replacement security is constituted in a manner reasonably acceptable to the Lender within such period of
time as the Lender may reasonably require, such event shall cease to constitute an Event of Default; or 

  

	9.1.15	the security constituted by the Security Documents is in any way materially imperilled or in jeopardy (including by way of depreciation in value beyond a normal
depreciation) provided however that if the Borrower proposes replacement security which the Lender accepts, and such replacement security is constituted in a manner acceptable to the Lender within such period of time as the Lender may require, such
event shall cease to constitute an Event of Default; or 

  

 9. 

 Execution Version 

 
  
  

	9.1.16	any other event (whether related or not) occurs (including, without limitation, a material (in the reasonable opinion of the Lender) adverse change, from the position
applicable as at the date of this Loan Agreement) in the business affairs or condition (financial or otherwise) of the Group), the effect of which is, in the reasonable opinion of the Lender, to materially imperil, delay or prevent the due
fulfilment by the Borrower of any of its obligations or undertakings in this Loan Agreement or the Security Documents; or 

  

	9.1.17	any event of default (howsoever described) specified in the Security Documents shall occur. 

 

	9.2	Lender’s Rights 

On or at any time following the occurrence of any Event of Default the Lender may: 

 

	9.2.1	serve on the Borrower a notice stating that all obligations of the Lender to the Borrower under this Loan Agreement including (without limitation) the obligation to
advance the Loan (or any part thereof) are terminated; and/or 

  

	9.2.2	serve on the Borrower a notice stating that the Loan, all accrued interest and all other amounts accrued or owing under this Loan Agreement are immediately due and
payable; and/or 

  

	9.2.3	take any other action which, as a result of the Event of Default or any notice served under Clauses 9.2.1 or 9.2.2 above, the Lender is entitled to take under the
Security Documents or any applicable law. 

  

	9.3	End of Lender’s Obligations 

On the service of a notice under Clause 9.2.1 and/or Clause 9.2.2, all the obligations of the Lender to the Borrower under this Loan
Agreement shall terminate 
  

	9.4	Acceleration 

 On the
service of a notice under Clause 9.2.2, the Loan, all accrued interest and all other amounts accrued or owing from the Borrower under this Loan Agreement and the Security Documents shall become immediately due and payable. 

 

	9.5	Waiver of Event of Default 

The Lender, at its sole and absolute discretion, may waive any Event of Default hereunder, prior to or after the event or events giving
rise thereto, provided that such waiver may be effected only by written notice provided by the Lender to the Borrower to that effect (and subject further to Clause 14.3 below); it being understood and acknowledged, that if and so long as no notice
of waiver of an Event of Default was so provided, such Event of Default shall be deemed as having occurred and in effect for all purposes hereunder. 
  

	10.	FEES, EXPENSES AND TAXES 

  

	10.1	Transaction Fee 

 The
Parties hereby agree and acknowledge that the Transaction Fee shall be paid by the Borrower to the Lender upon the date of this Loan Agreement. 

 

	10.2	Documentary Costs 

 The
Borrower shall pay to the Lender on the Lender’s demand, the reasonable legal expenses plus applicable VAT reasonably incurred by the Lender in connection with the negotiation and execution of this Loan Agreement and the Security Documents and
the transactions contemplated hereby and thereby (up to a cap of €20,000 plus VAT). 
  

	10.3	Certain taxes and duties 

The Borrower shall promptly pay any documentary, stamp or other equivalent tax or duty payable on or by reference to this Loan Agreement
or the Security Documents, and shall, on the Lender’s demand, fully indemnify the Lender against any liabilities and expenses resulting from any failure or delay by the Borrower to pay such a tax. 

 

	10.4	Recovery of Overdue Fees 

Without prejudice to any other provisions of this Loan Agreement, the Lender shall be entitled (and the Borrower hereby irrevocably
authorises the Lender), at any time and from time to time, to apply any credit balance to which the Borrower is then entitled on any account with the Lender in satisfaction of the sum or sums from time to time owing by the Borrower to the Lender
under and/or pursuant to this Clause 10. The Lender shall give notice to the Borrower of any such application promptly thereafter. 
  

	10.5	Liability for Taxes 

  

	10.5.1	The Borrower shall make all payments to be made by it without any Tax deduction, unless a Tax deduction is required by law. The Borrower shall promptly upon becoming
aware that it must make a Tax deduction (or that there is any change in the rate or the basis of a Tax deduction) notify the Lender. 

  

	10.5.2	If a Tax deduction is required by law to be made by the Borrower, the amount of the payment due from the Borrower shall be increased to an amount which (after making
any Tax deduction) leaves an amount equal to the payment which would have been due if no Tax deduction had been required. 

  

	10.5.3	If the Borrower is required to make a Tax deduction, the Borrower shall make that Tax deduction and any payment required in connection with that Tax deduction within
the time allowed and in the minimum amount required by law. 

  

	10.5.4	Within thirty (30) days of making either a Tax deduction or any payment required in connection with that Tax deduction, the Borrower shall deliver to the Lender
evidence reasonably satisfactory to it that the Tax deduction has been made or (as applicable) any appropriate payment paid to the relevant taxing authority. 

 

	10.5.5	 The Lender undertakes to do all things reasonably necessary in order to facilitate the making of a claim by the Borrower to any relevant taxing
authority in order that the Borrower may pay all interest and/or any other amounts under this Agreement 

  

 10. 

 Execution Version 

 

	 	 
or the Security Documents without any tax deduction. 

  

	10.6	Illegality and Increased Costs 

  

	10.6.1	If it is or becomes contrary to any law or regulation for the Lender to make available the Loan Facility or to maintain its obligations to do so or fund the Loan, the
Lender shall promptly notify the Borrower whereupon (a) the Lender’s obligations to make the Loan Facility available shall be terminated and (b) the Borrower shall be obliged to prepay the Loan either (i) forthwith or
(ii) on a future specified date on or before the latest date permitted by the relevant law or regulation. 

  

	10.6.2	If the result of any change in, or to the generally accepted interpretation or application of, or the introduction of, any law or regulation is to subject the Lender to
Taxes or change the basis of the payment of Taxes by the Lender with respect to any payment under this Agreement (other than Taxes on the overall net income, profits or gains of the Lender), then (i) the Lender shall notify the Borrower in
writing of such event promptly upon its becoming aware of the same; and (ii) the Borrower shall on demand, made at any time whether or not the Loan has been repaid, pay to the Lender the amount of the increased costs which the Lender proves it
has suffered as a result. 

  

	11.	INDEMNITIES 

  

	11.1	Indemnity for Non-Scheduled Payments Without derogating from Clause 10 above, the Borrower shall indemnify the Lender fully on its demand in respect of all
expenses, liabilities and losses which are suffered or incurred by the Lender, as a result of or in connection with: 

  

	11.1.1	the Loan not being borrowed on the date specified in the Drawdown Notice for any reason other than a default by the Lender; 

 

	11.1.2	any failure (for whatever reason) by the Borrower to make payment of any amount due under this Loan Agreement or the Security Documents on the due date or, if so
payable, on demand; or 

  

	11.1.3	the occurrence and/or continuance of an Event of Default and/or the acceleration of repayment of the Loan under Clause 9.4, and in respect of any Taxes for which the
Lender is liable or held liable in connection with any amount paid or payable to the Lender (whether for its own account or otherwise) under this Agreement or the Security Documents. 

 

	11.1.4	Notwithstanding anything to the contrary herein, the Borrower shall not indemnify the Lender for any consequential or indirect damages and is in no event whatsoever
obliged to pay any punitive damages. 

  

	11.2	Third Party Claims Indemnity 

The Borrower shall indemnify the Lender fully on its demand in respect of claims, demands, proceedings, liabilities, taxes, losses and
expenses of every kind, including without limitation attorney’s fees (“liability items”) which may be made or brought against, or incurred by, the Lender, in any country, in relation to: 

 

	11.2.1	any action lawfully taken, or omitted or neglected to be taken, under or in connection with this Loan Agreement or the Security Documents by the Lender or by any
receiver appointed under the Security Documents after the occurrence of any Event of Default; and 

  

	11.2.2	any breach or inaccuracy of any of the representations and/or warranties contained in Clause 7 hereof or in the Security Documents or any breach of any covenant,
commitment or agreement by the Borrower contained in Clause 8 hereof or elsewhere in this Agreement or in the Security Documents. 

  

	11.2.3	Notwithstanding anything to the contrary herein, the Borrower shall not indemnify the Lender or any third party for any consequential or indirect damages and is in no
event whatsoever obliged to pay any punitive damages. 

  

	12.	RISK AND INSURANCE 

  

	12.1	All risk of loss, theft and damage of and to the Charged Assets from any cause whatsoever shall be the risk of the Borrower, and no such event shall relieve the
Borrower of any obligation under a Drawdown Notice. 

  

	12.2	The Borrower shall: 

  

	12.2.1	bear all risk of loss of or damage to the Charged Assets whether insured against or not; 

 

	12.2.2	maintain with an reputable independent insurance company, to the extent available and in accordance with good and prudent practices of owners of such Charged Assets,
fully comprehensive insurance under a standard form of “new for old” all risks policy including terrorism, third party, and business interruption for a 6 month period covering (i) loss of or damage to, the Charged Assets and against
such other risks as assets of the same type as the Charged Assets are normally (or when used in the manner or for the purposes for which the Charged Assets are to be used) insured, and the new replacement value of the Charged Assets; and
(ii) all liability whatsoever (including liability of the Lender) to any third party whomsoever including any employee, agent or sub-contractor of the Lender or of the Borrower who may suffer damage to or loss of property or death or personal
injury, whether arising directly or indirectly from the Charged Assets or their use; for the avoidance of doubt, the Parties acknowledge that there is no such insurance available for the Intellectual Property rights and the accounts receivable of
the Borrower. 

  

	12.2.3	procure to the extent available under good Swiss market practice and permissible under Swiss laws that the Lender and, if the Lender so requests, any affiliates of the
Lender is an additional insured and that the interest of the Lender is noted under the policy and that the Lender is loss payee; 

  

	12.2.4	upon request produce to the Lender the policy and all premium receipts; 

  

 11. 

 Execution Version 

 

	12.2.5	promptly notify the Lender of any event which may give rise to a claim under the policy and upon request irrevocably appoint the Lender to be its sole agent to
negotiate agree or compromise such claim; and 

  

	12.2.6	upon request assign by way of security, or following the occurrence of an Event of Default, a complete assignment to the Lender the Borrower’s rights under such
policy and irrevocably appoint the Lender to institute any necessary proceedings. 

  

	13.	END OF LOAN PAYMENT 

The Borrower shall be required to pay the Lender, at the time of the last payment on the Loan, the End of Loan Payment. Upon payment of
the End of Loan Payment, subject to the terms of this Loan Agreement and the Security Documents (including the making of all payments hereunder and thereunder), the Lender shall take appropriate action to release the Security over the Charged
Assets. Failure to pay End of Loan Payment shall constitute a breach of this Loan Agreement. 
  

	14.	GENERAL 

  

	14.1	All agreements, covenants, representations and warranties of the Borrower contained in this Loan Agreement or in the Drawdown Notices or other documents delivered
pursuant hereto or in connection herewith shall survive the execution and delivery, and the expiration, cancellation or other termination of this Loan Agreement and/or the Drawdown Notice. 

 

	14.2	If the Borrower shall fail to perform any of its obligations under any Drawdown Notice duly and promptly, the Lender may, at its option and at any time, perform the
same without waiving any default on the part of the Borrower, or any of the Lender’s rights. The Borrower shall reimburse the Lender, within five (5) Business Days after notice thereof is given to the Borrower, for all expenses and
liabilities incurred by the Lender in the performance of the Borrower’s obligations. 

  

	14.3	The Lender’s failure at any time to require strict performance by the Borrower shall not constitute waiver of, or diminish, the Lender’s right to demand
strict compliance with any provision of the Loan. Waiver by the Lender of any default shall not constitute waiver of any other default. No rights or remedies referred to herein shall be exclusive, but shall be cumulative and in addition to any other
right or remedy set forth herein or otherwise available to the Borrower at law or in equity. 

  

	14.4	During the Loan Term, the Borrower shall provide the Lender with a first offer for additional debt or loan financing thirty (30) days prior to the time that such
requests are provided to other financing sources. Should the Lender and the Borrower fail to agree on the terms and conditions of such financing within five (5) Business Days, then the Borrower may accept a funding source other than the Lender.

 

	14.5	The Borrower may not assign or transfer its rights, benefits and obligations under this Loan Agreement. The Lender shall have the right, in its sole discretion, to
assign, sell, pledge, grant a security interest in or otherwise encumber its rights under this Loan Agreement and/or one or more Drawdown Notices to any third party (an “Assignee”), or may be acting as an agent for any Assignee in entering
into any Drawdown Notice. The Borrower hereby irrevocably consents to any assignment, sale, pledge, grant of a security interest or any other disposal to an Assignee. The Borrower agrees that if it receives notice from the Lender that it is to make
payments under this Loan Agreement and/or any Drawdown Notice to such Assignee rather than to the Lender, or that any of its other obligations under the relevant Drawdown Notice are to be owed to the named Assignee, the Borrower shall comply with
any such notice. Subject to the foregoing, this Loan Agreement and each Drawdown Notice inures to the benefit of, and is binding upon, the successors and assigns of the Lender. 

 

	14.6	The Lender shall keep strictly confidential all information directly or indirectly disclosed by the Borrower whether in writing, in oral form or in electronic form.

  

	14.6.1	The Lender shall use the information solely for the purpose of this Loan Agreement and/or the Securities Documents. 

 

	14.6.2	The Lender shall only disclose the information to those of its directors, employees, financial and legal advisors and Affiliates and those of the Affiliates’
directors, employees, financial and legal advisors who require such information for the purposes of this Loan Agreement and/or the Securities Documents and/or the Warrant (the “Permitted Parties”). 

 

	14.6.3	The Lender shall ensure that any Permitted Party to whom disclosure of information of the Borrower is made has undertaken the same confidentiality obligations
vis-à-vis the Borrower as the Lender under this Loan Agreement. 

  

	14.6.4	This confidentiality undertaking shall not apply to (i) information in the public domain other than where it reaches the public domain due to acts or omissions by
the Lender or any person for whom the Lender is responsible which are inconsistent with this undertaking; (ii) or information which was in the possession of the Lender prior to such disclosure; or (iii) information which is received by the
Lender from a third party without obligations of confidentiality vis-a-vis the Borrower; (iv) or information which the Lender is compelled to disclose by operation of law provided that the Lender has taken all reasonably practical steps to
notify the Borrower of any attempt being made to compel such disclosure. 

  

 12. 

 Execution Version 

 

	14.7	All notices related hereto shall be delivered or posted: 

  

	(i)	to the Lender’s address, with a copy to Donatella Callegaris, Kreos Capital, 39-40 Albemarle Street, London W1S 4TE and James Watts, Campbell Hooper, 35 Old Queen
Street, London SW1H 9JD; and 

  

	(ii)	to the Borrower’s address or at such other address as either party may designate in writing to the other party. 

 

	14.8	Clause titles are solely for convenience and are not an aid in the interpretation of this Loan Agreement. 

 

	14.9	If any provision or remedy herein provided is determined invalid under applicable law, such provision shall be inapplicable and deemed omitted; but the remaining
provisions, including remaining default remedies, shall be given effect in accordance with their terms. 

  

	14.10	A person who is not a party to this Agreement has no right under the Contract (Rights of Third Parties) Act 1999 to enforce or enjoy the benefits of this Agreement.

  

	14.11	This Loan Agreement, together with the Security Documents, constitutes the entire agreement between the parties with respect to the subject matter hereof. This Loan
Agreement may not be modified except in writing executed by the Lender and the Borrower, No supplier or agent of the Lender is authorised to bind the Lender or to waive or modify any term of this Loan Agreement. 

 

	14.12	This Loan Agreement may be executed in counterparts (including facsimile copies), each of which shall be an original, but all such counterparts shall together
constitute one and the same instrument. 

  

	14.13	This Loan Agreement shall be governed by English law and the parties accept the non-exclusive jurisdiction of the courts of England.

      

  

 13. 

 Execution Version 

 

 SCHEDULE A 

FORM OF SECURITY DOCUMENTS 
  

 14. 

 Execution Version 

 

 SCHEDULE B 

FORM OF DRAWDOWN NOTICE 

DRAWDOWN NOTICE 

Drawdown 

No. [    ] 

dated            2008 

between 
  

			
	KREOS CAPITAL III (UK) LIMITED	 	NITEC PHARMA AG
		
	the (“Lender”)	 	the (“Borrower”)

 This
Drawdown Notice forms a Schedule to a Loan Agreement between the Lender and the Borrower dated [            ] 2008 (the “Loan Agreement”) 

The Lender has granted the Borrower a loan facility pursuant to the terms and conditions set out in the Loan Agreement and attached Schedules.

 Words and expressions in this Drawdown Notice shall have the same meanings as in the Loan Agreement. 

 

 15. 

 Execution Version 

 

 PART 1 

Loan Details 
  

				
	Total Loan Facility	  	[Euros 7,500,000	] 
		
	Amount of Loan Facility to be drawn down pursuant to this Drawdown Notice	  	Euros [        	] 
		
	Loan Term	  	[36 months	] 
		
	Bank Account Details for remittance of funds	  	[        	] 
		
	Drawdown Date (which shall be a Business Day no be later than the Date of Expiry of the Loan Facility)	  	[            ] 200[    	] 

 The principal
will be repaid and interest shall be paid monthly in accordance with the Appendix to this Drawdown Notice. 
 We confirm that 

 

	(a)	the representations and warranties made by us in the Loan Agreement are true and accurate on the date of this Drawdown Notice as if made on such date; and

  

	(b)	no Event of Default has occurred and is continuing or would result from the delivery of this Drawdown Notice. 

We represent and warrant that the details in Appendix A are true and accurate and not misleading. 

 

									
	 for and on behalf of

NITEC PHARMA AG
	 		 		 	
					
	Authorised Signatory	 	 /s/ Anders Härfstrand
	 		 		 	 /s/ Andrea Buscaglia

	Name	 	ANDERS HÄRFSTRAND	 		 		 	ANDREA BUSCAGLIA
		 	CEO	 		 		 	CFO
				
	Dated [            ] 2008	 		 		 	

  

 16. 

 Execution Version 

 

 APPENDIX 

Interest and Principal Payment Due Dates 

[                       
     ] 
  

 17. 

 Execution Version 

 

 Duly executed by the parties on the date first set out on the first page of this Loan Agreement. 

 BORROWER 
 Signed

 For and on behalf of 
 NITEC
PHARMA AG 
 Authorised signatory 
  

							
	Name:	  	 /s/ Anders Härfstrand
	  		  	 /s/ Andrea Buscaglia

		  	ANDERS HÄRFSTRAND	  		  	ANDREA BUSCAGLIA
	Title:	  	CEO	  		  	CFO

 LENDER 

Signed 
 For and on behalf of 

KREOS CAPITAL III (UK) LIMITED 

Authorised signatory 
  

					
	 /s/ Maurizio Petitbon
	  	
	Name:	  	MAURIZIO PETITBON	  	
	Title:	  	DIRECTOR	  	

  

 18.

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