Document:

April 01, 2010	

 

  

Myeloma Health LLC

Anthony P. Albino, Ph.D.

667 Madison Avenue, 14th Floor

New York, New York 10065

 

Dear Dr. Albino:

 

In accordance with Article 5.1(e), Reimbursement of Patent Prosecution
Costs, of the License Agreement, dated April 01, 2010, between Myeloma Health, LLC and the Board of Trustees of the university
of Arkansas (“University”), Myeloma Health, LLC shall reimburse the University for (i) one hundred percent (100%) of
the gene expression profiling only patent costs, (ii) fifty percent (50%) of combination of gene expression profiling and fluorescence
in situ hybridization (FISH) patent costs, and (iii) zero percent (0%) of the fluorescence in situ-hybridization (FISH)-only patent
costs incurred by University and paid to third parties in connection with the preparation, filing, prosecution and maintenance
of patent applications and patents.

 

The purpose of this letter is to warrant and certify (i) the
total amount of such out-of-pocket costs incurred by University prior to the Effective Date; and (ii) detail the amount owed by
Myeloma Health, LLC to the University in accordance with the provisions of paragraph one above.

 

As of invoices received from third parties by the University
on March 29, 2010, for the patent applications listed in Appendix A (attached hereto) of the License Agreement, dated April 01,
2010, between Myeloma Health, LLC and the Board of Trustees of the University of Arkansas:

 

		(i)	Total Patent Costs: $388,657.09

 

		(ii)	Myeloma Health: $331,425.59

		a.	$120,179.00 – I02-08 Patent Family

		b.	$48,576.00 – I04-12 Patent Family

		c.	$68,434.50 – I07-00 Patent Family & IpEngines Analysis

		d.	$94,233.09 – Additional Patent Rights desired by Myeloma Health, LLC

 

Invoicing and reimbursements of the patent cost incurred by
University after the Effective Date shall be accomplished in accordance with Article 5.1(e)(iii) of the License Agreement.

 

Warrant and Certify by:

 

/s/ Michael G. Douglas, Ph.D.

 

Michael G. Douglas, Ph.D.

Director, UAMS Bio Ventures

 

		Cc:	Latham & Watkins LLP

Attention: Stuart Kurlander, Esq.Exhibit 10.3

 

	 	 	EXECUTION COPY

 

FIRST
AMENDMENT TO LICENSE AGREEMENT

 

THIS FIRST AMENDMENT
(this “AMENDMENT”), made as of September 1, 2010 amends the certain License Agreement, effective as of April
1, 2010 (the “AGREEMENT”), entered into by and between the Board of Trustees of the University of Arkansas acting
for and on behalf of the University of Arkansas for Medical Sciences, a public institution of higher education having principal
offices at 2404 North University Avenue, Little Rock, Arkansas 72207, United States of America (hereinafter “UNIVERSITY”),
and Myeloma Health LLC, a Delaware limited liability company having a principal office at 667 Madison Avenue, 14th Floor,
New York, New York 10065 (hereinafter “LICENSEE”), and shall be effective as of the EFFECTIVE DATE (as such
term is defined in the AGREEMENT).

 

WITNESSETH

 

WHEREAS, UNIVERSITY
and LICENSEE wish to amend the AGREEMENT to recognize that the following patent applications, identified by UNIVERSITY disclosure
numbers: I09-08 and I09-08PCT (the “I09-08 FILINGS”), I09-29 (the “I09-29 FILINGS”), I10-07
(the “I10-07 FILINGS”), I10-14 (the “I10-14 FILINGS”), I10-19 (the “I10-19 FILINGS”)
and I11-01 (the “I11-01 FILINGS”) are within the scope of the PATENT RIGHTS (as such term is defined in the
AGREEMENT) under Section 2.12(a).

 

NOW, THEREFORE, UNIVERSITY
and LICENSEE hereby amend the AGREEMENT as follows:

 

		1.	UNIVERSITY and LICENSEE acknowledge and agree that the I09-08 FILINGS, I09-29 FILINGS, I10-07
                                                          FILINGS, I10-14 FILINGS and I10-19 FILINGS are within the scope of the PATENT RIGHTS under Section 2.12(a). As a consequence,
                                                          Appendix A shall be revised to include the following new table entries:

 

	“Uses
    of Bortezomib in Predicting Survival in Multiple Myeloma Patients”
	UAMS Disclosure #	Applications	Publications	U.S. Patents	Overseas Publication	Overseas Patents
	I09-08	US61/204,154	 	Pending	 	 
	I09-08PCT	PCT/US2010/000002	 	Pending	 	 

 

    	 

    	 

    

 

	 	 	 

 

	“High
    IL6R and Myeloma Resistance to Thalidomide”
	UAMS Disclosure #	Applications	Publications	U.S. Patents	Overseas Publication	Overseas Patents
	I09-29	US61/278,878	 	Pending	 	 

 

	“High-Risk Myeloma Is Associated with Global Elevation of miRNAs and Overexpression of EIF2C2/AG02”
	UAMS Disclosure #	Applications	Publications	U.S. Patents	Overseas Publication	Overseas Patents
	I10-07

	US61/283,521

	 	Pending	 	 

 

	“Glucocorticoid Receptor (NR3C1) mRNA Levels in Tumor Cells as a Predictor of Outcome and Dexamethasone
dosing in Patients”
	UAMS Disclosure #	Applications	Publications	U.S. Patents	Overseas Publication	Overseas Patents
	I10-14

	Pending Patent Committee Review

	 	 	 	 

 

	“A 14 Gene Signature Distinguishing Ultra High Risk from Manageable GEP70 High Risk Disease Represent Biomarkers
and Therapeutic Targets”
	UAMS Disclosure #	Applications	Publications	U.S. Patents	Overseas Publication	Overseas Patents
	I10-19

	Provisional filed June 04, 2010

	 	Pending	 	 

 

	“Identification
    of Genes Coding for Plasma Membrane Reccptors Overexpressed on Cancer Calls as a Result of Copy Number Gains:
    Thrombin Receptor (PAR1) as a Biomarker and Therapeutic Target”
	UAMS Disclosure #	Applications	Publications	U.S. Patents	Overseas Publication	Overseas Patents
	I11-01

	Provisional to be filed

	 	 	 	 

 

		2.	Appendix B shall be revised to include the following new table entry under the heading “The
following patent applications are included in PATENT RIGHTS and apply to both fluorescence in situ hybridization
(FISH) testing and the LICENSED FIELD:”

 

	UAMS Disclosure #	Applications
	I09-29	US61/278,878

 

    	 

    	 

    

	 	 	 

 

		3.	UNIVERSITY and LICENSEE acknowledge and agree that the patent costs incurred by UNIVERSITY and
paid to third parties in connection with the preparation, filing, prosecution and maintenance, as of invoices received:

 

		a.	as of the EFFECTIVE DATE are as follows:

 

		(i)	I09-08 FILINGS: $10,037,

 

		(ii)	I09-29 FILINGS: $2,462,

 

		(iii)	I10-07 FILINGS: $1,116,

 

		(iv)	I10-14 FILINGS: $3,485,

 

		(v)	I10-19 FILINGS: $1,371, and

 

		(vi)	I11-01 FILINGS: $4,822

 

		b.	after the EFFECTIVE DATE are as follows:

 

		(i)	I09-08 FILINGS:,

		(ii)	I09-29 FILINGS:,

		(iii)	I10-07 FILINGS:,

		(iv)	I10-14 FILINGS:,

		(v)	I10-19 FILINGS:, and

		(vi)	I11-01 FILINGS:.

 

The amount
of such patent costs that LICENSEE shall reimburse to UNIVERSITY shall be determined in accordance with Section 5.1(e) (i) (the
“I09-08, I09-08PCT, I09-29, I10-07, I10-14, I10-19 and I11-01 PATENT COSTS”).

 

		4.	UNIVERSITY shall amend the separate letter signed by an authorized representative of UNIVERSITY
pursuant to Section 5.1(e) (ii) to include the I09-08, I09-08PCT, I09-29, I10-07, I10-14, I10-19 and I11-01 PATENT COSTS incurred by UNIVERSITY
prior to the EFFECTIVE DATE.

 

    	 

    	 

    

 

	 	 	 

 

		5.	LICENSEE shall pay to UNIVERSITY:

 

		a.	the patent costs for the I09-08, I09-08PCT, I09-29, I10-07, I10-14, I10-19 and I11-01 PATENT COSTS incurred
by UNIVERSITY prior to the EFFECTIVE DATE in accordance with Section 5.1(e)(ii).

 

		b.	the patent costs for the I09-08, I09-08PCT, I09-29, I10-07, I10-14, I10-19 and I11-01 PATENT COSTS incurred
by UNIVERSITY after the EFFECTIVE DATE in accordance with Section 5.1(e)(iii)

 

		6.	Except as provided herein above, all other terms and conditions of the AGREEMENT remain the same
and in effect.

 

(Signature page follows)

 

    	 

    	 

    

	 	 	EXECUTION COPY

 

IN WITNESS WHEREOF,
the PARTIES hereto have caused this AMENDMENT to be executed by their duly authorized representatives.

 

	BOARD OF TRUSTEES OF THE	 	MYELOMA HEALTH LLC
	UNIVERSITY OF ARKANSAS	 	 	 
	 	 	 	 	 
	/s/ Ann Kemp	 	/s/ Joe Hernandez
	By:	Ann Kemp	 	By:	Joe Hernandez
	Title:	Vice President for Administration	 	Title:	Chief Executive Officer
	 	 	 	 	 
	Date:	8/26/10	 	Date: 	8/19/10

 

[Signature Page to First Amendment to License
Agreement]Exhibit 10.3.1

 

		
         

         

         

        

 

 

February 25, 2014

 

 

 

Sam Riccitelli

President & CEO

Myeloma Health, LLC

667 Madison Avenue, 14th Floor

New York, NY 10065

 

Dear Mr. Riccitelli,

 

In accordance with Article 5.1(e), Reimbursement of Patent Prosecution
costs, of the License agreement, dated April 01,2010, between Myeloma Health, LLC and the Board of Trustees of the University of
Arkansas (“University”), Myeloma Health, LLC shall reimburse the University for (i) one hundred percent (100%) of the
gene expression profiling only patent costs, (ii) fifty percent (50%) of combination of gene expression profiling and fluorescence
in situ hybridization (FISH) patent costs, and (iii) zero percent (0%) of the fluorescence in situ hybridization (FISH)-only patent
costs incurred by University and paid to third parties in connection with the preparation, filing, prosecution and maintenance
of patent applications and patents.

 

The purpose of this letter is to warrant and certify (i) the
total amount of such out-of-pocket costs incurred by University prior to the Effective date; and, (ii) detail the amount owed by
Myeloma Health, LLC to the University in accordance with the provisions of paragraph one above.

 

As of invoices received from third parties by the University
on March 29, 2010, for the patent applications listed in Appendix A (attached hereto) of the License Agreement, dated April 01,
2010, between Myeloma Health, LLC and the Board of Trustees of the University of Arkansas:

 

(i)Total Patent Costs: $388,654.09

(ii)Myeloma Health: $331,422.59

a.$120,179.00 — 102-08 Patent
Family
 b.$ 48,576.00 — 104-12 Patent Family
 c.$ 68,434.50 — 107-00 Patent Family &
IpEngines’ Analysis
 d.$ 94,233.09 — Additional Patent Rights desired by Myeloma Health, LLC

 

    	 

    	 

    

 

 

Page 2

 

 

As of August 30, 2010, additional patent filings and invoices
on existing patent filings which are included in the first amendment to the License Agreement, dated September 1, 2010, between
Myeloma Health, LLC and the Board of Trustees of the University of Arkansas are as follows:

 

(iii)Total Patent Costs: $25,755

(iv)Myeloma Health: $23,293

a.$10,037 — 109-08 Patent Family

b.$ 2,462 — 109-29 Patent Family

c.$ 1,116 — 110-07 Patent Family

d.$ 3,485 — 110-14 Patent Family

e.$ 1,371 — 110-19 Patent Family

f.$ 4,822 — 111-01 Patent Family

 

Invoicing and reimbursements of the patent costs incurred by
University after the Effective Dates shall be accomplished in accordance with Article 5.1(e) (iii) of the License Agreement, and
Amendment thereto.

 

Warrant and Certify by:

 

/s/ Marie Chow, Ph.D.

 

Marie Chow, Ph.D.

 

Interim Director, UAMS BioVentures

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