Document:

EX-10.9

 EXHIBIT 10.9 

EXECUTION VERSION 
 AMENDMENT
NO. 2 
 AMENDMENT NO. 2 dated as of November 10, 2016 (this “Incremental Amendment”), to the CREDIT AGREEMENT
dated as of August 18, 2015 (as amended by that certain Amendment No. 1, dated as of May 31, 2016, and as further amended, restated, amended and restated, supplemented or otherwise modified prior to the date hereof, the
“Credit Agreement”), among JAGUAR HOLDING COMPANY II, a Delaware corporation (the “Parent Borrower”), PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC, a Delaware limited liability company (the “Subsidiary
Borrower”), JAGUAR HOLDING COMPANY I, a Delaware corporation (“Holdings”), each lender from time to time party thereto (collectively, the “Lenders” and, individually, a “Lender”), and
CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, as Administrative Agent, Collateral Agent and an L/C Issuer. Capitalized terms used but not otherwise defined herein shall have the respective meanings ascribed to such terms in the Credit Agreement. 

A. The Borrowers have notified the Incremental Term Loan Lender and the Incremental Arrangers (each as defined below) that they
intend to pay a cash dividend to the direct or indirect equityholders of Parent Borrower in an aggregate amount of $525,000,000 (the “Special Dividend”). 

B. Pursuant to Section 2.14 of the Credit Agreement, the Borrowers have requested an increase in the aggregate principal
amount of the existing Term Loan Tranche outstanding under the Credit Agreement on the terms and conditions set forth herein and in the Credit Agreement, and the Borrowers have appointed JPMorgan Chase Bank, N.A., Barclays Bank PLC, UBS Securities
LLC, Goldman Sachs Bank USA, Morgan Stanley Senior Funding, Inc. and Credit Suisse Securities (USA) LLC as the Incremental Arrangers and Joint Bookrunners in connection therewith (collectively, the “Incremental Arrangers”). 

C. Accordingly, in consideration of the mutual agreements herein contained and other good and valuable consideration, the
sufficiency and receipt of which are hereby acknowledged, the parties hereto agree to this Incremental Amendment. 
 SECTION 1.
Incremental Amendment. 
 a. On and as of the Incremental Amendment Effective Date (as defined below), the party hereto
providing the Incremental Term Loan Commitment (as defined below) as indicated on Annex I hereto (the “Incremental Term Loan Lender”) hereby provides the Incremental Term Loan Commitment set forth opposite its name on Annex I
attached hereto (it being agreed that the Incremental Term Loans (as defined below) shall be funded at 99.75% of the principal amount thereof, and notwithstanding said discount all calculations hereunder and under the Credit Agreement with respect
to the Incremental Term Loans, including the accrual of interest and the repayment or prepayment of principal, shall be based on 100% of the stated principal amount thereof) on the terms and subject to the conditions provided for herein (the
“Incremental Term Loan Commitment” and the loans to be made in respect thereof subject to the terms and conditions provided for herein, the “Incremental Term Loans”). The Incremental Term Loans shall be provided in
accordance with, and be subject to all of the terms and conditions set forth in, the Credit Agreement (including, without limitation, Section 2.14 thereof). 

 b. The Incremental Term Loan Lender, Holdings and the Borrowers acknowledge and agree that
upon the incurrence of Incremental Term Loans pursuant to the Incremental Term Loan Commitment, such loans shall constitute Initial Term Loans (and Term Loans and Loans) for all purposes of the Credit Agreement and the other applicable Loan
Documents. It is understood and agreed that on the date of the making of the Incremental Term Loans, and notwithstanding anything to the contrary set forth in Section 2.02 of the Credit Agreement, the Incremental Term Loans shall be added to
(and form part of) each Term Borrowing of outstanding Term Loans on a pro rata basis (based on the relative sizes of the various outstanding Term Borrowings), so that each Lender of Term Loans will participate proportionately in each then
outstanding Borrowing of Term Loans. 
 c. The Incremental Term Loan Lender, Holdings and the Borrowers agree to the terms and conditions set
forth herein in respect of the Incremental Term Loan Commitment provided pursuant to this Incremental Amendment. 
 d. The Incremental Term
Loan Lender (i) confirms that it has received a copy of the Credit Agreement and the other Loan Documents, together with copies of the financial statements referred to therein, and such other documents and information as it has deemed
appropriate to make its own credit analysis and decision to enter into this Incremental Amendment and to become a Lender under the Credit Agreement, (ii) agrees that it will, independently and without reliance upon the Administrative Agent, the
Incremental Arrangers or any other Lender and based on such documents and information as it shall deem appropriate at the time, continue to make its own credit decisions in taking or not taking action under the Credit Agreement and the other Loan
Documents, (iii) acknowledges and agrees that no fiduciary or advisory relationship between the Administrative Agent and/or the Incremental Arrangers, on the one hand, and the Incremental Term Loan Lender, on the other hand, is intended to be
or has been created in respect of any of the transactions contemplated by this Incremental Amendment, (iv) acknowledges and agrees that the Incremental Term Loan Lender is capable of evaluating and understanding, and it understands and accepts,
the terms, risks and conditions of the transactions contemplated by this Incremental Amendment, (v) acknowledges and agrees that the Administrative Agent, the Incremental Arrangers or any of their respective Affiliates may have received fees or
other compensation from Holdings or any of its Affiliates in connection with this Incremental Amendment which may or may not be publicly disclosed and such fees or compensation do not affect the Incremental Term Loan Lender’s independent credit
decision to enter into the transactions contemplated by this Incremental Amendment, (vi) acknowledges and agrees that notwithstanding that no fiduciary or similar relationship exists between the Administrative Agent and/or the Incremental
Arrangers, on the one hand, and the Incremental Term Loan Lender, on the other hand, the Incremental Term Loan Lender hereby waives, to the fullest extent permitted by law, any claims it may have against the Administrative Agent, the Incremental
Arrangers or their respective Affiliates for breach of fiduciary duty or alleged breach of fiduciary duty and agrees that the Administrative Agent, the Incremental Arrangers and their respective Affiliates shall have no liability (whether direct or
indirect) to the Incremental Term Loan Lender in respect of such a fiduciary duty claim or to any Person asserting a fiduciary duty claim on behalf of or in right of the Incremental Term Loan Lender, including the Incremental Term Loan Lender’s
stockholders, employees or creditors, (vii) appoints and authorizes the Administrative Agent to take such action as agent on its behalf and to exercise such powers under the Credit Agreement and the other Loan Documents as are delegated to the
Administrative Agent by the terms thereof, together with such powers as are reasonably incidental thereto and (viii) agrees that it will perform in accordance with their terms all of the obligations which by the terms of the Credit Agreement
and the other Loan Documents are required to be performed by it as a Lender or a Term Lender. 

  
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 e. Upon (x) the occurrence of the Incremental Amendment Effective Date and (y) the
satisfaction (or waiver as provided for therein) of the conditions precedent set forth in Section 7 below, the Incremental Term Loan Lender (i) shall be obligated to make the Incremental Term Loans committed to be made by it as provided in
this Incremental Amendment on the date such conditions are so satisfied (or waived), on the terms, and subject to the conditions, set forth in the Credit Agreement and in this Incremental Amendment and (ii) to the extent provided in this
Incremental Amendment, shall have the rights and obligations of a Lender and a Term Lender thereunder and under the other applicable Loan Documents; provided that (x) if the conditions precedent set forth in Section 7 below are not
satisfied (or waived) on or prior to November 10, 2016 (the “Incremental Commitment Termination Date”), then the Incremental Term Loan Commitment shall immediately terminate and the Incremental Term Loan Lender shall have no
further obligation hereunder to make Incremental Term Loans to the Borrowers and (y) only one drawing of Incremental Term Loans may be made by the Borrowers on or prior to the Incremental Commitment Termination Date. 

f. The Borrowers acknowledge and agree that (i) they shall be liable for all Obligations with respect to the Incremental Term Loan
Commitment provided hereby, including, without limitation, all Incremental Term Loans made pursuant hereto and (ii) all such Obligations (including all such Incremental Term Loans) shall be entitled to the benefits of the Collateral Documents
and each Guaranty. 
 g. Each Guarantor acknowledges and agrees that all Obligations with respect to the Incremental Term Loan Commitment
provided hereby and all Incremental Term Loans made pursuant thereto (i) shall be fully guaranteed pursuant to their respective Guaranties as, and to the extent, provided therein and in the Credit Agreement and shall constitute Guaranteed
Obligations under and as defined in the Guaranties and (ii) are fully secured by the Collateral Documents and shall be entitled to the benefits of their respective Collateral Documents as, and to the extent, provided therein and in the Credit
Agreement and shall constitute Secured Obligations under and as defined in the Security Agreement. 
 h. The Incremental Term Loans to be
made as provided in this Incremental Amendment shall constitute an increase in the existing Term Loan Tranche outstanding under the Credit Agreement and shall be on the same terms as, and become part of, the existing Term Loan Tranche under the
Credit Agreement. The Borrowers hereby unconditionally promise to repay the Term Loans (including the Incremental Term Loans) in accordance with the schedule of installment payments set forth in Section 2.07(a) of the Credit Agreement (after
giving effect to the amendments thereto effected hereby and as the same may be further adjusted in accordance with the provisions of the Credit Agreement). Interest will begin accruing on the Incremental Term Loans on the Incremental Loan Funding
Date (as defined below). 
 i. On and as of the date of the funding of the Incremental Term Loans to the Borrowers hereunder (the
“Incremental Loan Funding Date”), the Borrowers and the other parties hereto agree that (i) unless the context clearly requires otherwise, the Incremental Term Loan Lender will be deemed to be a “Lender” for all
purposes of the Credit Agreement and the other Loan Documents (and each reference therein to the “Lenders” will be deemed to include the Incremental Term Loan Lender), (ii) unless the context clearly requires otherwise, the definitions of
the terms “Initial Term Loans”, “Term Loans”, “Loans” and “Term Facility” shall be deemed modified to include the Incremental Term Loans, (iii) Section 1.01 of the Credit Agreement is hereby amended
by inserting the following definition in appropriate alphabetical order therein: “Amendment No. 2” means Amendment No. 2, dated as of November 10, 2016, to this Agreement, (iv) Section 1.01 of the Credit Agreement
is hereby amended by inserting the following definition in appropriate alphabetical order therein: “Amendment No. 2 Effective Date” means November 10, 2016 and (v) Section 2.07(a) of the Credit Agreement shall be
deleted in its entirety and be replaced with the new Section 2.07(a) contained in Annex II hereto. 

  
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 SECTION 2. Representations and Warranties. The Borrowers hereby represent and
warrant, on the date hereof and as of the Incremental Loan Funding Date (before and after giving effect to the making of the Incremental Term Loans) that: 

(i) no Default or Event of Default exists, both before and after giving effect to this Incremental Amendment and the
making of the Incremental Term Loans, or would result from the application of the proceeds of the Incremental Term Loans; 

(ii) the representations and warranties of the Borrowers and each other Loan Party contained in Article V of the Credit
Agreement or in any other Loan Document are true and correct in all material respects (and in all respects if any such representation or warranty is already qualified by materiality), both before and after giving effect to this Incremental
Amendment, except to the extent that any such representation or warranty specifically refers to an earlier date, in which case such representation or warranty was true and correct in all material respects (and in all respects if any such
representation or warranty is already qualified by materiality) as of such earlier date (and except that, for purposes of this clause (ii), the representations and warranties contained in Sections 5.05(a) and 5.05(b) of the Credit Agreement shall be
deemed to refer to the most recent financial statements furnished pursuant to Section 6.01(a) and (b), respectively, of the Credit Agreement prior to the Incremental Amendment Effective Date); 

(iii)this Incremental Amendment has been duly authorized, executed and delivered by the Borrowers and each other Loan Party,
and this Incremental Amendment constitutes a legal, valid and binding obligation of the Borrowers and each other Loan Party, enforceable against the Borrowers and each other Loan Party in accordance with its terms, except as such enforceability may
be limited by bankruptcy, insolvency, reorganization, receivership, moratorium or other laws affecting creditors’ rights generally and by general principles of equity; and 

(iv) after giving effect to the extensions of credit under this Incremental Amendment and the payment of the Special
Dividend, the Borrowers and their Subsidiaries, on a consolidated basis, are Solvent. 
 SECTION 3. Reference To And Effect Upon The
Credit Agreement. (a) From and after the Incremental Loan Funding Date and the making of the Incremental Term Loans, (i) the term “Agreement” in the Credit Agreement, and all references to the Credit Agreement in any
other Loan Document, shall mean the Credit Agreement as modified hereby, and (ii) this Incremental Amendment shall constitute a Loan Document for all purposes of the Credit Agreement and the other Loan Documents. 

(b) Each Loan Party hereby acknowledges that it has read this Incremental Amendment and consents to the terms hereof and further hereby
affirms, confirms and agrees that (i) notwithstanding the effectiveness of this Incremental Amendment, the obligations of such Loan Party under each of the Loan Documents to which it is a party shall not be impaired and each of the Loan
Documents to which such Loan Party is a party is, and shall continue to be, in full force and effect and is hereby confirmed and ratified in all respects, in each case, as amended hereby; and (ii) its Guarantee of the Obligations, and the
pledge of and/or grant of a security 

  
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 interest in its assets as Collateral to secure the Obligations, all as and to the extent provided in the
Collateral Documents, shall continue in full force and effect in respect of, and to secure, the Obligations (including, without limitation, in respect of the Incremental Term Loans) and shall accrue to the benefit of the Secured Parties (including
the holders of Incremental Term Loans). Without limiting the foregoing, as security for the payment or performance, as the case may be, in full of the Obligations, each Loan Party hereby grants to the Collateral Agent, for the ratable benefit of the
Secured Parties, a security interest in all right, title and interest now owned or at any time hereafter acquired in the Collateral (as defined in each Collateral Document). 

(c) Except as expressly set forth herein, this Incremental Amendment shall not by implication or otherwise limit, impair, constitute a waiver
of, or otherwise affect the rights and remedies of the Lenders, the L/C Issuers, the Administrative Agent, the Collateral Agent or any other Secured Party under the Credit Agreement or any other Loan Document, and shall not alter, modify, amend or
in any way affect any of the terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any other Loan Document, all of which are ratified and affirmed in all respects and shall continue in full force and effect.
This Incremental Amendment shall apply and be effective only with respect to the provisions of the Credit Agreement and the other Loan Documents specifically referred to herein. This Incremental Amendment shall not extinguish the Obligations for the
payment of money outstanding under the Loan Documents or discharge or release the Liens granted in any Collateral Document or any security therefor or any guarantee thereof, and the Liens and security interests for the benefit of the Secured Parties
securing payment of the Obligations are in all respects continuing and in full force and effect with respect to all Obligations. Nothing herein contained shall be construed as a substitution or novation, or a payment and reborrowing, or a
termination, of the Obligations outstanding under the Loan Documents or instruments guaranteeing or securing the same, which shall remain in full force and effect, except as modified hereby or by instruments executed concurrently herewith. 

SECTION 4. Counterparts, Etc. This Incremental Amendment may be executed in any number of counterparts, each of which when so
executed shall be deemed an original, but all such counterparts shall constitute one and the same instrument, and all signatures need not appear on any one counterpart. Any party hereto may execute and deliver a counterpart of this Incremental
Amendment by delivering by facsimile or other electronic transmission a signature page of this Incremental Amendment signed by such party, and any such facsimile or other electronic signature shall be treated in all respects as having the same
effect as an original signature. Section headings in this Incremental Amendment are included herein for convenience of reference only and shall not constitute part of this Incremental Amendment for any other purpose. 

SECTION 5. Governing Law; Jurisdiction; Etc. The provisions of Sections 3.06, 10.15 and 10.17 of the Credit
Agreement shall apply to this Incremental Amendment, mutatis mutandis. 
 SECTION 6. Effectiveness of this Incremental
Amendment. This Incremental Amendment shall become effective at the time (the “Incremental Amendment Effective Date”) when the Administrative Agent shall have received duly executed signature pages for this Incremental
Amendment signed by the Administrative Agent, each Loan Party, the Incremental Term Loan Lender and the Incremental Arrangers. 

  
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 SECTION 7. Conditions to Incremental Loan Funding Date. Notwithstanding
anything herein to the contrary, the obligation of the Incremental Term Loan Lender to make the Incremental Term Loans to the Borrowers pursuant to the Incremental Term Loan Commitment is subject to satisfaction (or waiver by the Incremental Term
Loan Lender and the Administrative Agent) of the following conditions precedent: 
  

	 	(i)	 all costs, fees, expenses and other compensation contemplated under the Credit Agreement or under the
Engagement Letter dated as of October 21, 2016, by and among Holdings, the Parent Borrower, the Subsidiary Borrower and each Incremental Arranger party thereto (the “Engagement Letter”), shall have been paid to the extent
applicable; and 

  

	 	(ii)	 each other condition precedent set forth in Section 7 of Annex I hereto shall have been satisfied
(or waived by the Incremental Term Loan Lender and the Administrative Agent). 

 The Incremental Arrangers shall promptly notify the
Borrowers and the Incremental Term Loan Lender of the Increase Effective Date with respect to the Incremental Term Loans as contemplated by Section 2.14(c) of the Credit Agreement. 

SECTION 8. Use of Proceeds. The Borrowers covenant and agree that, promptly after their receipt of the proceeds of the
Incremental Term Loans, they will use such proceeds solely (a) to finance a portion of the Special Dividend and to pay fees and expenses incurred in connection therewith and (b) to pay any other amounts required to be paid by them in
connection with the Special Dividend and the Engagement Letter. 
 SECTION 9. Real Estate Collateral. The Borrowers shall, and shall
cause their respective Subsidiaries to, deliver to the Collateral Agent as soon as practicable and in any event within 90 calendar days after the Incremental Loan Funding Date (or such longer period as the Collateral Agent may agree in its sole
discretion), (a) an amendment to each Mortgage encumbering the Mortgaged Properties in form suitable for recording that shall provide such Mortgage remains in full force and effect and continues to secure the Obligations, as amended by this
Incremental Amendment, which mortgage amendment shall be in form and substance reasonably acceptable to the Collateral Agent and its counsel in all respects, (b) endorsements to the mortgagee’s title insurance policies reflecting the
amendment to the insured Mortgage as well as a date down endorsement in respect of each of the Mortgaged Properties, reflecting that there are no encumbrances affecting the Mortgaged Properties except as permitted under the Credit Agreement, and in
each case in form and substance reasonably satisfactory to the Collateral Agent, (c) a customary opinion of local counsel in each jurisdiction in which a Mortgage Property is located for the benefit of the Collateral Agent with respect to the
enforceability of the Mortgages as amended, together with such other opinions as the Collateral Agent shall require, and in form and substance reasonably acceptable to the Collateral Agent and (d) such further documents, instruments, acts or
agreements as the Collateral Agent may reasonably request to affirm, secure, renew or perfect the liens of the Mortgages as amended; provided that if and to the extent that on or prior to the Incremental Loan Funding Date the Borrowers
deliver to the Collateral Agent (x) an opinion of local counsel in form and substance reasonably acceptable to the Collateral Agent affirming that no amendment to an existing Mortgage is necessary for such Mortgage to remain in full force and
effect and to secure the Obligations, as modified by the transactions contemplated by this Incremental Amendment, as well as (y)

  
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a title report (or title update) showing no Liens, other than Liens permitted by the applicable Mortgage, have arisen with respect to such property since the date of the latest title policy or
date-down endorsement, then the Collateral Agent will accept such deliveries in lieu of the requirements set forth in clauses (a) through (d) of this sentence with respect to such property. All of the actions referenced above shall be taken,
and documents referenced above shall be delivered, at the sole expense of the Borrowers, including any recording charges, taxes, or other associated costs related thereto. 

[Signature Pages follow] 

  
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 IN WITNESS WHEREOF, this Incremental Amendment has been executed by the parties hereto as of
the date first written above. 
  

			
	JAGUAR HOLDING COMPANY I
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	General Counsel and Secretary
	
	JAGUAR HOLDING COMPANY II
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	General Counsel and Secretary
	
	PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	General Counsel and Secretary
	
	ACURIAN, INC.
	CLINICAL RESEARCH ADVANTAGE, INC.
	CNS RESEARCH SCIENCE, INC.
	CRA INTERMEDIATE HOLDINGS, INC.
	INNOVA HOLDINGS, INC.
	PPD INVESTIGATOR SERVICES, LLC
	RADIANT RESEARCH, INC.
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	General Counsel and Secretary

  
 [Signature Page –
Amendment No. 2 to the Credit Agreement] 

 
			
	APPLIED BIOSCIENCE INTERNATIONAL, LLC
	ATP, LLC
	PPD AERONAUTICS, LLC
	PPD GLOBAL CENTRAL LABS, LLC
	PPD HOLDINGS, LLC
	PPD SERVICES, INC.
	RIVER VENTURES, LLC
	PPD VACCINES AND BIOLOGICS, LLC
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Vice President and Secretary
	
	PHARMACO INVESTMENTS, INC.
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	President and Secretary
	
	JAGUAR CAYMAN FINANCE LIMITED
		
	By:	 	 /s/ Brian S. Tuttle

	Name:	 	Brian S. Tuttle
	Title:	 	Director
	
	WILDCAT ACQUISITION HOLDINGS (UK) LIMITED
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Director

  
 [Signature Page –
Amendment No. 2 to the Credit Agreement] 

 
			
	PPD DEVELOPMENT, L.P.
	
	By: PPD GP, LLC, its general partner
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Vice President, General Counsel and Secretary
	
	PPD GP, LLC
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Vice President, General Counsel and Secretary
	
	EVIDERA HOLDINGS, INC.
	EVIDERA, INC.
	EVAL YTICA, INC.
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Secretary
	
	EVIDERA LLC
	
	By: EVIDERA, INC., its sole member
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Secretary

  
 [Signature Page –
Amendment No. 2 to the Credit Agreement] 

 
			
	 CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, as Administrative Agent and Collateral
Agent

		
	By:	 	 /s/ Robert Hetu

	Name:	 	Robert Hetu
	Title:	 	Authorized Signatory
		
	By:	 	 /s/ Whitney Gaston

	Name:	 	Whitney Gaston
	Title:	 	Authorized Signatory
	
	 JPMORGAN CHASE BANK, N.A., as Incremental Term Loan Lender and as an Incremental
Arranger

		
	By:	 	 /s/ Vanessa Chiu

	Name:	 	 Vanessa Chiu

	Title:	 	Executive Director
	
	BARCLAYS BANK PLC, as an Incremental Arranger
		
	By:	 	 /s/ Marguerite Sutton

	Name:	 	Marguerite Sutton
	Title:	 	Vice President

  
 [Signature Page –
Amendment No. 2 to the Credit Agreement] 

 
			
	UBS SECURITIES LLC, as an Incremental Arranger
		
	By:	 	 /s/ Anthony Tre

	Name:	 	Anthony Tre
	Title:	 	Executive Director 
		
	By:	 	 /s/ Anthony Dep 

	Name:	 	Anthony Dep 
	Title:	 	Executive Director
	
	 GOLDMAN SACHS BANK USA, as an Incremental Arranger

		
	By:	 	 /s/ Thomas M. Manning

	Name:	 	Thomas M. Manning
	Title:	 	Authorized Signatory
	
	 MORGAN STANLEY SENIOR FUNDING, INC., as an Incremental Arranger

		
	By:	 	 /s/ Nehal Abdel Hakim

	Name:	 	Nehal Abdel Hakim 
	Title:	 	Authorized Signatory
	
	 CREDIT SUISSE SECURITIES (USA) LLC, as an Incremental Arranger

		
	By:	 	 /s/ Thomas Davidson

	Name:	 	Thomas Davidson
	Title:	 	Managing Director

  
 [Signature Page –
Amendment No. 2 to the Credit Agreement] 

 ANNEX I 

TERMS AND CONDITIONS FOR INCREMENTAL TERM LOAN COMMITMENT 

1. Names of Borrowers: JAGUAR HOLDING COMPANY II and PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC (on a joint and several basis). 

2. Incremental Term Loan Commitment amounts (as of the Incremental Amendment Effective Date): 

 

			
	 Name of the Incremental Term Loan
Lender
	  	 Amount of Incremental Term Loan
Commitment

	JPMorgan Chase Bank, N.A.	  	$460,000,000.00

 3. Incremental Term Loan Borrowing Date: The date on which the conditions precedent in Section 7 of this Incremental
Amendment are satisfied or waived as provided therein. 
 4. Maturity Date: Same as applicable to the existing Term Loans. 

5. Interest Period: The initial Interest Period with respect to the Incremental Term Loans shall be determined in a manner that gives effect to the intent and
purpose of the last sentence of Section 1(b) of this Incremental Amendment to which this Annex I is attached. 
 6. Other terms: Same as those
applicable to the existing Term Loans. 
 7. Other Conditions Precedent: 

a. The Administrative Agent shall have received such customary documents and certifications (including Organizational Documents and, if
applicable, good standing certificates) as the Administrative Agent may reasonably require to evidence (A) the identity, authority and capacity of each Responsible Officer of the Loan Parties acting as such in connection with this Incremental
Amendment and the other Loan Documents and (B) that Holdings, the Borrowers and each Subsidiary Guarantor is duly organized or formed, and that each of them is validly existing and, to the extent applicable, in good standing, except to the
extent that failure to be so qualified could not reasonably be expected to have a Material Adverse Effect, including certification by a Responsible Officer of each Borrower that the conditions specified in clauses (i) through (iii) of
Section 2.14(d) of the Credit Agreement have been satisfied and that the conditions set forth in this Annex I have been satisfied. 
 b.
The Administrative Agent shall have received, if requested by the Incremental Term Loan Lender reasonably in advance of the Incremental Loan Funding Date, a Term Note executed by the Borrowers in favor of the Incremental Term Loan Lender. 

c. The Administrative Agent shall have received a Committed Loan Notice relating to the incurrence of the Incremental Term Loans. 

d. The Administrative Agent shall have received a solvency certificate executed by the chief financial officer or similar officer, director,
manager or authorized signatory of the Parent Borrower (after giving effect to the funding of the Incremental Term Loans to the Borrowers and the payment of the Special Dividend). 

  

 e. The Administrative Agent shall have received an opinion of Latham & Watkins LLP,
special New York, Delaware and California counsel to the Loan Parties, addressed to the Administrative Agent and the Incremental Term Loan Lender, in form and substance reasonably satisfactory to the Administrative Agent. 

f. Holdings, the Borrowers and the Guarantors shall have provided the documentation and other information reasonably requested in writing prior
to the Incremental Loan Funding Date by the Incremental Term Loan Lender in connection with applicable “know your customer” and anti-money-laundering rules and regulations, including the PATRIOT Act. 

g. The conditions set forth in Section 4.02 of the Credit Agreement shall have been satisfied. 

h. The conditions set forth in Section 2.14 of the Credit Agreement to the making of an increase in the existing Term Loan Tranche in the
manner provided for in this Incremental Amendment shall have been satisfied. 
 i. Subject to Section 9 of this Incremental Amendment,
all actions or documents reasonably requested by the Administrative Agent that are necessary to establish or re-affirm that the Collateral Agent will have a perfected first priority security interest (subject
to Liens permitted under Section 6.02 of the Credit Agreement) in the Collateral to secure the Incremental Term Loans shall have been taken or executed and delivered (including, if so requested, deeds of confirmation, amendments and/or
supplements to Collateral Documents). 
 j. The Borrowers shall have delivered to the Administrative Agent the financial statements required
by Section 6.01(b) of the Credit Agreement for the fiscal quarter ending September 30, 2016, and the associated Compliance Certificate required by Section 6.02(b) of the Credit Agreement. 

 

 ANNEX II 

NEW SECTION 2.07(a) 
 (a) Term
Loans. The Borrowers shall repay to the Administrative Agent for the ratable account of the applicable Term Lenders the aggregate principal amount of all Initial Term Loans outstanding in consecutive quarterly installments as follows (which
installments shall, to the extent applicable, be reduced as a result of the application of prepayments made after the Amendment No. 2 Effective Date in accordance with the order of priority set forth in Sections 2.05 and 2.06, or be increased
as a result of any increase in the amount of Initial Term Loans made after the Amendment No. 2 Effective Date pursuant to Section 2.14 (such increased amortization payments to be calculated in the same manner (and on the same basis) as the
schedule set forth below for the Initial Term Loans made on the Closing Date and the funding dates contemplated by Amendment No. 1 and Amendment No. 2)): 
  

					
	 Date
	  	Term Loan Principal
Amortization Payment	 
	 December 31, 2016
	  	$	8,105,835.30	 
	 March 31, 2017
	  	$	8,105,835.30	 
	 June 30, 2017
	  	$	8,105,835.30	 
	 September 30, 2017
	  	$	8,105,835.30	 
	 December 31, 2017
	  	$	8,105,835.30	 
	 March 31, 2018
	  	$	8,105,835.30	 
	 June 30, 2018
	  	$	8,105,835.30	 
	 September 30, 2018
	  	$	8,105,835.30	 
	 December 31, 2018
	  	$	8,105,835.30	 
	 March 31, 2019
	  	$	8,105,835.30	 
	 June 30, 2019
	  	$	8,105,835.30	 
	 September 30, 2019
	  	$	8,105,835.30	 
	 December 31, 2019
	  	$	8,105,835.30	 
	 March 31, 2020
	  	$	8,105,835.30	 
	 June 30, 2020
	  	$	8,105,835.30	 
	 September 30, 2020
	  	$	8,105,835.30	 
	 December 31, 2020
	  	$	8,105,835.30	 
	 March 31, 2021
	  	$	8,105,835.30	 
	 June 30, 2021
	  	$	8,105,835.30	 
	 September 30, 2021
	  	$	8,105,835.30	 
	 December 31, 2021
	  	$	8,105,835.30	 
	 March 31, 2022
	  	$	8,105,835.30	 
	 June 30, 2022
	  	$	8,105,835.30	 
	 Maturity Date for Term Facility
	  	$	3,015,370,731.42	 

 provided, however, that the final principal repayment installment of the Initial Term Loans shall be repaid on
the Maturity Date for the Initial Term Loans and in any event shall be in an amount equal to the aggregate principal amount of all Initial Term Loans outstanding on such date.EX-10.10

 EXHIBIT 10.10 

EXECUTION VERSION 
 AMENDMENT NO. 3
dated as of May 30, 2017 (this “Amendment”), to the CREDIT AGREEMENT dated as of August 18, 2015, as amended by that certain Amendment No. 1, dated as of May 31, 2016 and that certain Amendment No. 2, dated as of November
10, 2016 (the “Credit Agreement”), among JAGUAR HOLDING COMPANY II, a Delaware corporation (the “Parent Borrower”), PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC, a Delaware limited liability company (the
“Subsidiary Borrower” and together with the Parent Borrower, the “Borrowers”), JAGUAR HOLDING COMPANY I, LLC (f/k/a JAGUAR HOLDING COMPANY I), a Delaware limited liability company (“Holdings”), each
lender from time to time party thereto (collectively, the “Lenders” and, individually, a “Lender”), and CREDIT SUISSE AG, CAYMAN ISLANDS BRANCH, as Administrative Agent (in such capacity, the “Administrative
Agent”), Collateral Agent (in such capacity, the “Collateral Agent”) and L/C Issuer. 
 A. Pursuant to the Credit
Agreement, (i) the Term Lenders made Term Loans on and after the Closing Date (the “Existing Term Loans”) to the Borrowers and (ii) the Revolving Credit Lenders made available to the Borrowers the Revolving Credit
Facility. 
 B. The Borrowers, Holdings and the Subsidiary Guarantors are party to one or more of the Collateral Documents, pursuant to
which, among other things, the Guarantors guaranteed the Obligations of the Borrowers under the Credit Agreement and provided security therefor. 

C. The Borrowers and Holdings have requested that the Credit Agreement be amended (i) to provide for new term loans (the “2017
Term Loans”) to be made to the Borrowers in an aggregate principal amount of $3,185,593,272.72 and having the terms set forth herein and as otherwise set forth for Term Loans under the Credit Agreement (after giving effect to the amendments
thereto provided for herein), the proceeds of which will be used by the Borrowers, together with cash on hand of the Borrowers, if necessary, to prepay in full all outstanding Existing Term Loans, to pay all accrued and unpaid interest thereon and
to pay all fees and expenses incurred in connection with the foregoing and (ii) as otherwise set forth herein. 
 D. Pursuant to
Section 2.18 of the Credit Agreement, the Borrowers may obtain Specified Refinancing Term Loans by, among other things, entering into a Refinancing Amendment in accordance with the terms and conditions of the Credit Agreement. 

 Accordingly, in consideration of the mutual agreements herein contained and other good and
valuable consideration, the sufficiency and receipt of which are hereby acknowledged, the parties hereto agree as follows: 
 SECTION 1.
Defined Terms. Capitalized terms used but not defined herein (including in the recitals hereto) shall have the meanings given to them in the Credit Agreement (as amended hereby). 

SECTION 2. Amendment to the Credit Agreement. Subject to the satisfaction or waiver of the conditions set forth in Section 5
hereof, the Credit Agreement is hereby amended as follows: 
 (a) Section 1.01 of the Credit Agreement is hereby amended by inserting
the following definitions in the appropriate alphabetical order therein: 
 “Amendment No. 3” means
Amendment No. 3, dated as of May 30, 2017, to this Agreement. 
 “Amendment No. 3 Effective
Date” means May 30, 2017. 
 (b) The definition of the term “Applicable Rate” in Section 1.01 of the
Credit Agreement is hereby amended and restated in its entirety as follows: 
 “Applicable Rate” means a percentage per
annum equal to: 
 (a) with respect to the Revolving Credit Facility, (i) from the Closing Date until the first Business
Day that immediately follows the date on which a Compliance Certificate is delivered pursuant to Section 6.02(b) in respect of the first full fiscal quarter ending after the Closing Date, 3.25% per annum for Eurocurrency Rate Loans and 2.25%
per annum for Base Rate Loans and (ii) thereafter, the applicable percentage per annum set forth below, as determined by reference to the First Lien Net Leverage Ratio, as set forth in the then most recent Compliance Certificate received by the
Administrative Agent pursuant to Section 6.02(b): 
  

													
	 Applicable Rate
	 
	 Pricing Level
	  	First Lien Net
Leverage Ratio	 	  	Eurocurrency
Rate Loans	 	 	Base Rate
Loans	 
	 1
	  	 	3 3.50:1.00	 	  	 	3.25	% 	 	 	2.25	% 
	 2
	  	 	< 3.50:1.00	 	  	 	3.00	% 	 	 	2.00	% 

 ; and 

(b) with respect to the Initial Term Loans made pursuant to Amendment No. 3, 2.75% per annum for Eurocurrency Rate Loans
and 1.75% per annum for Base Rate Loans. 
 Under clause (a) of this definition, any increase or decrease in the
Applicable Rate resulting from a change in the First Lien Net Leverage Ratio shall become effective as of the first Business Day immediately following the date a Compliance Certificate is delivered pursuant to Section 6.02(b); provided,
however, that “Pricing Level 1” shall apply without regard to the First Lien Net Leverage Ratio (x) at any time after the date on which any annual or quarterly financial statement was required to have been delivered
pursuant to Section 6.01(a) or Section 6.01(b) but was not delivered (or the 

  
 2 

 
Compliance Certificate related to such financial statements was required to have been delivered pursuant to Section 6.02(b) but was not delivered), commencing with the first Business Day
immediately following such date and continuing until the first Business Day immediately following the date on which such financial statements (or, if later, the Compliance Certificate related to such financial statements) are delivered, or
(y) at all times if an Event of Default shall have occurred and be continuing. 
 Notwithstanding anything to the
contrary contained in this definition, the determination of the Applicable Rate under clause (a) of this definition for any period shall be subject to the provisions of Section 2.10(b).” 

(c) The definition of “Initial Term Borrowing” in Section 1.01 of the Credit Agreement is hereby amended by
(i) inserting “or Amendment No. 3” immediately following “Section 2.01(a)” and (ii) inserting “or the Amendment No. 3 Effective Date, as applicable” immediately following “Closing
Date”. 
 (d) The definition of “Initial Term Commitment” in Section 1.01 of the Credit Agreement is hereby
amended and restated in its entirety as follows: 
 “Initial Term Commitment” means, as to each Term Lender, its obligation
to make Initial Term Loans to the Parent Borrower pursuant to Section 2.01(a) in an aggregate principal amount not to exceed the amount set forth opposite such Term Lender’s name on Schedule I to Amendment No. 3 under the caption
“Commitment” as such amount may be adjusted from time to time in accordance with this Agreement. The initial aggregate amount of the Initial Term Commitments as of the Amendment No. 3 Effective Date is $3,185,593,272.72. 

(e) The definition of “Term Loan Tranche” in Section 1.01 of the Credit Agreement is hereby amended and restated in its
entirety as follows: 
 “Term Loan Tranche” means the respective facility and commitments utilized in making Term Loans
hereunder, with there being one Tranche on the Amendment No. 3 Effective Date, i.e. Initial Term Loans and Initial Term Commitments. Additional Term Loan Tranches may be added after the Closing Date, i.e., New Term Loans, Specified
Refinancing Term Loans, New Term Commitments and Specified Refinancing Term Commitments. 
 (f) The last sentence of the definition of
“Pro Rata Share” in Section 1.01 of the Credit Agreement is hereby amended by inserting “as of the Closing Date” immediately following “The initial Pro Rata Share of each Lender”. 

(g) Section 2.01(a) of the Credit Agreement is hereby amended by replacing the reference to “the Closing Date” therein with
“the Amendment No. 3 Effective Date”. 

  
 3 

 (h) Section 2.05(a)(iii) of the Credit Agreement is hereby amended by replacing the
reference to “the Closing Date” therein with “the Amendment No. 3 Effective Date”. 
 (i) Section 2.06(b)(i) of
the Credit Agreement is hereby amended by adding “provided prior to the Amendment No. 3 Effective Date” immediately before “shall be the Closing Date”. 

(j) Section 2.07(a) of the Credit Agreement is hereby amended and restated in its entirety as follows: 

(a) Initial Term Loans. The Borrowers shall repay to the Administrative Agent for the ratable account of the applicable
Term Lenders the aggregate principal amount of all Initial Term Loans outstanding in consecutive quarterly installments as follows (which installments shall, to the extent applicable, be reduced as a result of the application of prepayments made
after the Amendment No. 3 Effective Date in accordance with the order of priority set forth in Sections 2.05 and 2.06, or be increased as a result of any increase in the amount of Initial Term Loans made after the Amendment No. 3 Effective
Date pursuant to Section 2.14 (such increased amortization payments to be calculated in the same manner (and on the same basis) as the schedule set forth below for the Initial Term Loans made on the Amendment No. 3 Effective Date)): 

 

					
	 Date
	  	Term Loan Principal
Amortization Payment	 
	 June 30, 2017
	  	$	8,105,835.30	 
	 September 30, 2017
	  	$	8,105,835.30	 
	 December 31, 2017
	  	$	8,105,835.30	 
	 March 31, 2018
	  	$	8,105,835.30	 
	 June 30, 2018
	  	$	8,105,835.30	 
	 September 30, 2018
	  	$	8,105,835.30	 
	 December 31, 2018
	  	$	8,105,835.30	 
	 March 31, 2019
	  	$	8,105,835.30	 
	 June 30, 2019
	  	$	8,105,835.30	 
	 September 30, 2019
	  	$	8,105,835.30	 
	 December 31, 2019
	  	$	8,105,835.30	 
	 March 31, 2020
	  	$	8,105,835.30	 
	 June 30, 2020
	  	$	8,105,835.30	 
	 September 30, 2020
	  	$	8,105,835.30	 
	 December 31, 2020
	  	$	8,105,835.30	 
	 March 31, 2021
	  	$	8,105,835.30	 
	 June 30, 2021
	  	$	8,105,835.30	 
	 September 30, 2021
	  	$	8,105,835.30	 
	 December 31, 2021
	  	$	8,105,835.30	 
	 March 31, 2022
	  	$	8,105,835.30	 
	 June 30, 2022
	  	$	8,105,835.30	 
	 Maturity Date for Initial Term Loans
	  	$	3,015,370,731.42	 

  
 4 

 provided, however, that the final principal repayment installment of the
Initial Term Loans shall be repaid on the Maturity Date for the Initial Term Loans and in any event shall be in an amount equal to the aggregate principal amount of all Initial Term Loans outstanding on such date. 

(k) Section 3.08(c) of the Credit Agreement is hereby amended by replacing the reference to “the Closing Date” therein with
“the Amendment No. 3 Effective Date”. 
 (l) Section 5.07 of the Credit Agreement is hereby amended by inserting
“made on the Closing Date” immediately following “use the proceeds of the Term Loans”. 
 (m) Section 6.11 of the
Credit Agreement is hereby amended by inserting “or Amendment No. 3” immediately following “5.20”. 
 SECTION 3.
Loans. 
 (a) Subject to the terms and conditions set forth herein and in the Credit Agreement, (i) each person designated as a
“Term Lender” on Schedule I hereto (each, a “2017 Term Lender”) agrees, severally and not jointly, to make a 2017 Term Loan to the Borrowers on the Amendment No. 3 Effective Date (as defined below) in an aggregate
principal amount not to exceed the amount set forth opposite its name on Schedule I hereto, and (ii) from and after the making of the 2017 Term Loans on the Amendment No. 3 Effective Date, (x) each 2017 Term Loan shall be a “Term
Loan” and a “Loan” and, unless the context requires a reference solely to the Term Loans made prior to the Amendment No. 3 Effective Date, an “Initial Term Loan” (for the avoidance of doubt, the Maturity Date for the
2017 Term Loans shall be the same as the Maturity Date for the Initial Term Loans made prior to the Amendment No. 3 Effective Date), (y) each Person that holds 2017 Term Loans from time to time shall be a “Term Lender” and a
“Lender”, and (z) the aggregate 2017 Term Loans of all Persons that hold 2017 Term Loans shall be the “Term Facility”, in each case, for all purposes under the Credit Agreement (as amended hereby) and the other Loan
Documents. Without limiting the foregoing, the Borrowers hereby unconditionally promise to repay the 2017 Term Loans in accordance with the schedule of installment payments set forth in Section 2.07(a) of the Credit Agreement (after giving
effect to the amendments thereto effected hereby and as the same may be further adjusted in accordance with the Credit Agreement). Amounts borrowed as 2017 Term Loans and subsequently repaid may not be reborrowed. The proceeds of the 2017 Term Loans
shall be used by the Borrowers solely to make the Loan Repayment (as defined below). For the avoidance of doubt, the making of the 2017 Term Loans hereunder shall constitute “Specified Refinancing Debt” within the meaning of
Section 2.18 of the Credit Agreement. 

  
 5 

 (b) On the Amendment No. 3 Effective Date, (i) the Borrowers shall prepay in full
all Existing Term Loans outstanding under the Credit Agreement, together with all accrued and unpaid interest thereon and all fees and expenses incurred in connection with the foregoing, with the proceeds of the 2017 Term Loans and, if necessary,
cash on hand of the Borrowers (collectively, the “Loan Repayment”). Notwithstanding the making of the Loan Repayment, the holders of the Existing Term Loans shall thereafter continue to be entitled to the benefits of Sections 3.01,
3.03, 3.04, 3.05, 3.06 and 10.04 of the Credit Agreement as in effect immediately prior to the Amendment No. 3 Effective Date and shall continue to be bound by Section 9.07 of the Credit Agreement as in effect immediately prior to the
Amendment No. 3 Effective Date. 
 SECTION 4. Representations and Warranties. The Borrowers hereby represent and warrant, on the
date hereof and as of the Amendment No. 3 Effective Date (both before and after giving effect to the making of the 2017 Term Loans) that: 

(a) no Default or Event of Default exists, both before and after giving effect to this Amendment and the making of the 2017 Term Loans, or
would result from the application of the proceeds of the 2017 Term Loans; 
 (b) the representations and warranties of the Borrowers and each
other Loan Party contained in Article V of the Credit Agreement or in any other Loan Document are true and correct in all material respects (and in all respects if any such representation or warranty is already qualified by materiality), both before
and after giving effect to this Amendment, except to the extent that any such representation or warranty specifically refers to an earlier date, in which case such representation or warranty was true and correct in all material respects (and in all
respects if any such representation or warranty is already qualified by materiality) as of such earlier date (and except that, for purposes of this clause (b), the representations and warranties contained in Sections 5.05(a) and 5.05(b) of the
Credit Agreement shall be deemed to refer to the most recent financial statements furnished pursuant to Section 6.01(a) and (b), respectively, of the Credit Agreement prior to the Amendment No. 3 Effective Date); 

(c) this Amendment has been duly authorized, executed and delivered by the Borrowers and each other Loan Party, and this Amendment constitutes
a legal, valid and binding obligation of the Borrowers and each other Loan Party, enforceable against the Borrowers and each other Loan Party in accordance with its terms, except as such enforceability may be limited by bankruptcy, insolvency,
reorganization, receivership, moratorium or other laws affecting creditors’ rights generally and by general principles of equity; and 

(d) after giving effect to the making of the 2017 Term Loans and the Loan Repayment, the Borrowers and their Subsidiaries, on a consolidated
basis, are Solvent. 

  
 6 

 SECTION 5. Amendment Effectiveness. The effectiveness of the amendments to the Credit
Agreement contemplated hereby and the obligations of each 2017 Term Lender to make any 2017 Term Loans hereunder shall be subject to the satisfaction (or waiver by each 2017 Term Lender party hereto), on or prior to the May 30, 2017, of the
following conditions (the first Business Day on which all conditions are so satisfied or waived and the 2017 Term Loans are made, the “Amendment No. 3 Effective Date”): 

(a) the Administrative Agent shall have received counterparts of this Amendment that, when taken together, bear the signatures of (i) the
Borrowers, Holdings and the Subsidiary Guarantors, (ii) the Administrative Agent and (iii) each 2017 Term Lender; 
 (b) the
Administrative Agent shall have received such customary certificates of resolutions or other action, incumbency certificates and/or other certificates of Responsible Officers of Holdings, the Borrowers and each Subsidiary Guarantor as the
Administrative Agent may reasonably require evidencing the identity, authority and capacity of each Responsible Officer thereof authorized to act as a Responsible Officer in connection with this Amendment; 

(c) the Administrative Agent shall have received (i) such documents and certifications (including Organization Documents and, to the
extent available under applicable local law, good standing certificates) as the Administrative Agent may reasonably require to evidence that Holdings, the Borrowers and each Subsidiary Guarantor is duly organized or formed, and that each of them is
validly existing, and, to the extent available under local law, in good standing and qualified to engage in business in each jurisdiction where its ownership, lease or operation of properties or the conduct of its business requires such
qualification, except to the extent that failure to be so qualified could not reasonably be expected to have a Material Adverse Effect; 

(d) the Administrative Agent shall have received a Committed Loan Notice relating to the incurrence of the 2017 Term Loans; 

(e) the Administrative Agent shall have received a solvency certificate executed by the chief financial officer or similar officer, director,
manager or authorized signatory of the Parent Borrower (after giving effect to the repayment of the Existing Term Loans and the funding of the 2017 Term Loans to the Borrowers); 

(f) the Administrative Agent shall have received an opinion of (i) Latham & Watkins LLP, special New York, Delaware, Texas and
California counsel to the Loan Parties, and (ii) Herbert Smith Freehills LLP, United Kingdom counsel to the Administrative Agent and each 2017 Term Lender, in each case in form and substance reasonably satisfactory to the Administrative Agent;

 (g) Holdings, the Borrowers and the Guarantors shall have provided the documentation and other information reasonably requested in writing
prior to the Amendment No. 3 Effective Date by the 2017 Term Lender in connection with applicable “know your customer” and anti-money-laundering rules and regulations, including the PATRIOT Act to the extent requested in writing no
less than three (3) days in advance of the Amendment No. 3 Effective Date; 

  
 7 

 (h) subject to Section 6 of this Amendment, all actions or documents reasonably
requested by the Administrative Agent that are necessary to establish or re-affirm that the Collateral Agent will have a perfected first priority security interest (subject to Liens permitted under
Section 7.02 of the Credit Agreement) in the Collateral to secure the 2017 Term Loans shall have been taken or executed and delivered (including, if so requested, deeds of confirmation, amendments and/or supplements to Collateral Documents);

 (i) the Administrative Agent and its affiliates shall have received from the Borrowers (or shall be satisfied that it will receive
substantially concurrently with the effectiveness of this Amendment) immediately available funds in an amount sufficient to consummate the Loan Repayment and pay all other fees and reimburse all expenses separately agreed in writing by the Borrowers
and any 2017 Term Lender or required by Section 10.04 of the Credit Agreement or by any other Loan Document to be paid by the Borrowers in connection with this Amendment and the transactions contemplated hereby (to the extent, in the case of
reimbursement of expenses, invoiced in reasonable detail on or prior to the date hereof); 
 (j) the representations and warranties set forth
in Section 4 above shall be true and correct, and no Default or Event of Default shall exist before or after giving effect to the transactions contemplated hereby (and the Administrative Agent shall have received a certification by a
Responsible Officer of each Borrower that the condition specified in this clause (j) have been satisfied); and 
 (k) substantially
concurrently with the effectiveness of this Amendment, the 2017 Term Loans shall have been made. 
 SECTION 6. Real Estate
Collateral. The Borrowers shall, and shall cause their respective Subsidiaries to, deliver to the Collateral Agent as soon as practicable and in any event within 90 calendar days after the Amendment No. 3 Effective Date (or such longer
period as the Collateral Agent may agree in its sole discretion), (a) an amendment to each Mortgage encumbering the Mortgaged Properties in form suitable for recording that shall provide such Mortgage remains in full force and effect and continues
to secure the Obligations, as amended by this Amendment, which mortgage amendment shall be in form and substance reasonably acceptable to the Collateral Agent and its counsel in all respects, (b) endorsements to the mortgagee’s title
insurance policies reflecting the amendment to the insured Mortgage as well as a date down endorsement in respect of each of the Mortgaged Properties, reflecting that there are no encumbrances affecting the Mortgaged Properties except as permitted
under the Credit Agreement, and in each case in form and substance reasonably satisfactory to the Collateral Agent, (c) a customary opinion of local counsel in each jurisdiction in which a Mortgage Property is located for the benefit of the
Collateral Agent with respect to the enforceability of the Mortgages as amended, together with such other opinions as the Collateral Agent shall require, and in form and substance reasonably acceptable to the Collateral Agent and (d) such
further documents, instruments, acts or agreements as the Collateral Agent may reasonably request to affirm, secure, renew or perfect 

  
 8 

 
the liens of the Mortgages as amended; provided that if and to the extent that on or prior to the Amendment No. 3 Effective Date the Borrowers deliver to the Collateral Agent
(x) an opinion of local counsel in form and substance reasonably acceptable to the Collateral Agent affirming that no amendment to an existing Mortgage is necessary for such Mortgage to remain in full force and effect and to secure the
Obligations, as modified by the transactions contemplated by this Amendment, as well as (y) a title report (or title update) showing no Liens, other than Liens permitted by the applicable Mortgage, have arisen with respect to such property
since the date of the latest title policy or date-down endorsement, then the Collateral Agent will accept such deliveries in lieu of the requirements set forth in clauses (a) through (d) of this sentence
with respect to such property. All of the actions referenced above shall be taken, and documents referenced above shall be delivered, at the sole expense of the Borrowers, including any recording charges, taxes, or other associated costs related
thereto. 
 SECTION 7. Effect of Amendment. Except as expressly set forth herein, this Amendment shall not by implication or
otherwise limit, impair, constitute a waiver of, or otherwise affect the rights and remedies of the Lenders, the L/C Issuers or the Administrative Agent under the Credit Agreement or any other Loan Document, and shall not alter, modify, amend or in
any way affect any of the terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any other Loan Document, all of which are ratified and affirmed in all respects and shall continue in full force and effect.
Nothing herein shall be deemed to entitle any Loan Party to a consent to, or a waiver, amendment, modification or other change of, any of the terms, conditions, obligations, covenants or agreements contained in the Credit Agreement or any other Loan
Document in similar or different circumstances. This Amendment shall apply and be effective only with respect to the provisions of the Credit Agreement specifically referred to herein. After the Amendment No. 3 Effective Date, any reference to
the Credit Agreement in any Loan Document, and the terms “this Agreement”, “herein”, “hereunder”, “hereto”, “hereof”, “hereby” and words of similar import in the Credit Agreement, shall,
unless the context otherwise requires, mean the Credit Agreement as modified hereby. This Amendment shall constitute a “Refinancing Amendment” and a “Loan Document” for all purposes of the Credit Agreement and the other Loan
Documents. This Amendment shall not extinguish the Obligations for the payment of money outstanding under the Credit Agreement (except as otherwise expressly provided with respect to the Loan Repayment) or discharge or release the Lien of any Loan
Document or any other security therefor or any guarantee thereof, and the Liens and security interests in favor of the Administrative Agent for the benefit of the Secured Parties securing payment of the Obligations are in all respects continuing and
in full force and effect with respect to all Obligations. Nothing herein contained shall be construed as a substitution or novation, or a payment and reborrowing, or a termination, of the Obligations outstanding under the Credit Agreement or
instruments guaranteeing or securing the same (except as otherwise expressly provided with respect to the Loan Repayment), which shall remain in full force and effect, except as modified hereby or by instruments executed concurrently herewith. 

  
 9 

 SECTION 8. Acknowledgement and Consent. Each Loan Party
hereby acknowledges that it has read this Amendment and consents to the terms hereof and further hereby affirms, confirms and agrees that (a) notwithstanding the effectiveness of this Amendment, the obligations of such Loan Party under each of
the Loan Documents to which 
 it is a party shall not be impaired and each of the Loan Documents to which such Loan Party is a party is, and shall continue
to be, in full force and effect and is hereby confirmed and ratified in all respects, in each case, as amended hereby; and (b) its Guarantee of the Obligations, and the pledge of and/or grant of a security interest in its assets as Collateral
to secure the Obligations, all as and to the extent provided in the Collateral Documents as originally executed, shall continue in full force and effect in respect of, and to secure, the Obligations (including, without limitation, the 2017 Term
Loans) and shall accrue to the benefit of the Secured Parties (including the holders of 2017 Term Loans). Without limiting the foregoing, as security for the payment or performance, as the case may be, in full of the Obligations, each Loan Party
hereby grants to the Collateral Agent, for the ratable benefit of the Secured Parties, a security interest in all right, title and interest now owned or at any time hereafter acquired in the Collateral (as defined in each Collateral Document). 

SECTION 9. Counterparts. This Amendment may be executed in one or more counterparts (and by different parties hereto in different
counterparts), each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Delivery by telecopier or other electronic transmission of an executed counterpart of a signature page to this
Amendment shall be effective as delivery of an original executed counterpart of this Amendment. The Administrative Agent may also require that any such documents and signatures delivered by telecopier or other electronic transmission be confirmed by
a manually-signed original thereof; provided that the failure to request or deliver the same shall not limit the effectiveness of any document or signature delivered by telecopier or other electronic transmission. 

SECTION 10. Governing Law; Jurisdiction; Etc. The provisions of Sections 3.06, 10.15 and 10.17 of the Credit Agreement shall apply to
this Amendment, mutatis mutandis. 
 SECTION 11. Headings. The headings of this Amendment are for purposes of reference only
and shall not limit or otherwise affect the meaning hereof. 
 [Remainder of this page intentionally left blank] 

  
 10 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly executed by
their duly authorized officers, all as of the date and year first above written. 
  

			
	JAGUAR HOLDING COMPANY I, LLC
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	General Counsel and Secretary
	
	JAGUAR HOLDING COMPANY II
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	General Counsel and Secretary
	
	PHARMACEUTICAL PRODUCT DEVELOPMENT, LLC
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	General Counsel and Secretary

 [SIGNATURE PAGE TO AMENDMENT
NO. 3 TO THE PPD CREDIT AGREEMENT] 

 
			
	 CLINICAL RESEARCH ADVANTAGE, INC. ACURIAN, INC.

CNS RESEARCH SCIENCE, INC. PPD INVESTIGATOR SERVICES, LLC

RADIANT RESEARCH, INC.

		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	General Counsel and Secretary
	
	EVIDERA, INC. EVALYTICA, INC. EVIDERA HOLDINGS, INC.
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Secretary
	
	EVIDERA, LLC
	By its sole member: Evidera, Inc.
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Secretary
	
	 SYNEXUS US HOLDING INC.

SYNEXUS HOLDING, LLC

		
	By:	 	 /s/ Christophe Berthoux

	Name:	 	Christophe Berthoux
	Title:	 	President and Chief Executive Officer

 [SIGNATURE PAGE TO AMENDMENT
NO. 3 TO THE PPD CREDIT AGREEMENT] 

 
			
	 APPLIED BIOSCIENCE INTERNATIONAL, LLC

PPD HOLDINGS, LLC
 PPD GLOBAL CENTRAL LABS, LLC ATP,
LLC
 PPD AERONAUTICS, LLC
 PPD SERVICES, INC.
RIVER VENTURES, LLC
 PPD VACCINES AND BIOLOGICS, LLC

		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Vice President and Secretary
	
	PHARMACO INVESTMENTS, INC.
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	President and Secretary
	
	PPD GP, LLC
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Vice President, General Counsel and Secretary
	
	SYNEXUS US, L.P.
		
	By:	 	 /s/ Kelly Walker

	Name:	 	Kelly Walker
	Title:	 	Chief Operating Officer

 [SIGNATURE PAGE TO AMENDMENT
NO. 3 TO THE PPD CREDIT AGREEMENT] 

 
			
	PPD DEVELOPMENT, L.P.
	By its general partner: PPD GP, LLC
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Vice President, General Counsel and Secretary
	
	JAGUAR (BARBADOS) FINANCE S.R.L.
		
	By:	 	 /s/ Nathan Perry Speicher

	Name:	 	Nathan Perry Speicher
	Title:	 	Manager
	
	WILDCAT ACQUISITION HOLDINGS (UK) LIMITED
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Director

 [SIGNATURE PAGE TO AMENDMENT
NO. 3 TO THE PPD CREDIT AGREEMENT] 

 
			
	CLINICAL RESEARCH ADVANTAGE, INC.
	ACURIAN, INC.
	CNS RESEARCH SCIENCE, INC.
	PPD INVESTIGATOR SERVICES, LLC
	RADIANT RESEARCH, INC.
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	General Counsel and Secretary
	
	EVIDERA, INC.
	EVALYTICA, INC.
	EVIDERA HOLDINGS, INC.
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Secretary
	
	EVIDERA, LLC
	By its sole member: Evidera, Inc.
		
	By:	 	 /s/ B. Judd Hartman

	Name:	 	B. Judd Hartman
	Title:	 	Secretary
	
	SYNEXUS US HOLDING INC.
	SYNEXUS HOLDING, LLC
		
	By:	 	/s/ Christophe Berthoux
	Name:	 	Christophe Berthoux
	Title:	 	President and Chief Executive Officer

 [SIGNATURE PAGE TO AMENDMENT
NO. 3 TO THE PPD CREDIT AGREEMENT] 

 
			
	CREDIT SUISSE AG, CAYMAN ISLANDS
	 BRANCH, as Administrative Agent, L/C Issuer,

Collateral Agent and Lender,

		
	by	 	/s/ Robert Hetu
	Name:	 	Robert Hetu
	Title:	 	Authorized Signatory
		
	by	 	/s/ Whitney Gaston
	Name:	 	Whitney Gaston
	Title:	 	Authorized Signatory

 [SIGNATURE PAGE TO AMENDMENT
NO. 3 TO THE PPD CREDIT AGREEMENT] 

 SCHEDULE I 

COMMITMENT SCHEDULE 
  

					
	 2017 Term Lender
	  	Commitment	 
	 Credit Suisse AG, Cayman Islands Branch
	  	$	3,185,593,272.72	 
	 Total
	  	$	3,185,593,272.72

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00303-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00303-of-00352.parquet"}]]