Document:

AMENDMENT
TO LOAN AND SECURITY AGREEMENT

 

This AMENDMENT to
Loan and Security Agreement (this “Amendment”) is entered into this 8th day of February 2012, by
and between Silicon Valley Bank (“Bank”) and Derycz Scientific, Inc., a Nevada corporation and Reprints Desk, Inc.,
a Delaware corporation (jointly and severally, the “Borrower”).

 

Recitals

A.Bank
and Borrower have entered into that certain Loan and Security Agreement dated as of July 23, 2010 (as the same may from time to
time be amended, modified, supplemented or restated, the “Loan Agreement”).

B.Bank
has extended credit to Borrower for the purposes permitted in the Loan Agreement.

C.Borrower
has requested that Bank amend the Loan Agreement, as herein set forth, and Bank has agreed to do the same, but only to the extent,
in accordance with the terms, subject to the conditions and in reliance upon the representations and warranties set forth below.

Agreement

Now,
Therefore, in consideration of the foregoing recitals and other good and valuable consideration, the receipt and adequacy
of which is hereby acknowledged, and intending to be legally bound, the parties hereto agree as follows:

1.Definitions.
Capitalized terms used but not defined in this Amendment shall have the meanings given to them in the Loan Agreement.

2.Amendments
to Loan Agreement. 

2.1Merger of
Pools Press, Inc. Pursuant to that certain Agreement and Plan of Merger dated as of January 1, 2012, Pools Press, Inc. (“PPI”)
merged with and into Reprints Desk, Inc. (“RDI”). As a result thereof, on the effective date of such merger, among
other things, RDI succeeded to all of PPI’s rights and property and became subject to all of PPI’s liabilities and
obligations. Therefore, effective upon the merger, RDI, without any further action, hereby assumes and agrees to perform for the
benefit of Bank all of the Obligations of PPI. 

2.2Limited
Waiver Regarding Minimum Tangible Net Worth Default. Borrower has advised Bank that Borrower has failed to comply with
the Minimum Tangible Net Worth Financial Covenant set forth in Section 6.9(b) of the Loan Agreement for the compliance period
ending December 31, 2011 (the “TNW Default”). Borrower hereby acknowledges the TNW Default. Bank and Borrower agree
that the Borrower's TNW Default is hereby waived. It is understood by the parties hereto, however, that such waiver does not constitute
a waiver of any other provision or term of the Loan Agreement or any related document, nor an agreement to waive in the future
this covenant or any other provision or term of the Loan Agreement or any related document.

    	-1-

    	 

    

2.3Modified
Interest Rates. Section 2.3(a) of the Loan Agreement is hereby amended in its entirety to read as follows:

(a)Advances. Subject
to Section 2.3(b), the principal amount outstanding under the Revolving Line shall accrue interest at a floating per annum rate
equal to (i) at all times when a Streamline Period is in effect, two and one-half percentage points (2.50%) above the Prime Rate
and (ii) at all times when a Streamline Period is not in effect, four and one-half percentage points (4.50%) above the Prime Rate,
which interest shall, in either case, be payable monthly in accordance with Section 2.3(f) below.

 

2.4Modified
Tangible Net Worth Financial Covenant. Section 6.9(b) of the Loan Agreement is hereby amended in its entirety to read as follows:

(b)Tangible Net Worth.
A Tangible Net Worth of at least the following:

 

For each
of the months from January 2012 through August 2012: $500,000 plus the increase provided for below;

 

For each
of the months from September 2012 through November 2012: $750,000 plus the increase provided for below; and

 

For the month
ending December 31, 2012 and each month ending thereafter: $1,000,000 plus the increase provided for below;

 

in each instance above, the dollar
amount shall be increased by (i) 50% of Net Income for the fiscal quarter ending December 31, 2011 and each fiscal quarter ending
thereafter and (ii) 50% of issuances of equity after January 1, 2012 and the principal amount of Subordinated Debt.

 

2.5Modified
Compliance Certificate. The form of Compliance Certificate, attached as Exhibit C to the Loan Agreement, is amended in its
entirety to read as set forth on Exhibit C attached hereto.

    	-2-

    	 

    

3.Limitation
of Amendments.

3.1The
amendments set forth in Section 2, above, are effective for the purposes set forth herein and shall be limited precisely
as written and shall not be deemed to (a) be a consent to any amendment, waiver or modification of any other term or condition
of any Loan Document, or (b) otherwise prejudice any right or remedy which Bank may now have or may have in the future under
or in connection with any Loan Document.

3.2This
Amendment shall be construed in connection with and as part of the Loan Documents and all terms, conditions, representations, warranties,
covenants and agreements set forth in the Loan Documents, except as herein amended, are hereby ratified and confirmed and shall
remain in full force and effect.

4.Representations
and Warranties. To induce Bank to enter into this Amendment, Borrower hereby represents and warrants to Bank as follows:

4.1Immediately
after giving effect to this Amendment (a) the representations and warranties contained in the Loan Documents are true, accurate
and complete in all material respects as of the date hereof (except to the extent such representations and warranties relate to
an earlier date, in which case they are true and correct as of such date), and (b) no Event of Default has occurred and is
continuing;

4.2Borrower
has the power and due authority to execute and deliver this Amendment; and

4.3The
organizational documents of Borrower delivered to Bank on the Effective Date remain true, accurate and complete and have not been
amended, supplemented or restated and are and continue to be in full force and effect.

4.4The
execution and delivery by Borrower of this Amendment and the performance by Borrower of its obligations under the Loan Agreement,
as amended by this Amendment, have been duly authorized;

4.5The
execution and delivery by Borrower of this Amendment and the performance by Borrower of its obligations under the Loan Agreement,
as amended by this Amendment, do not and will not contravene (a) any law or regulation binding on or affecting Borrower, (b) any
contractual restriction with a Person binding on Borrower, (c) any order, judgment or decree of any court or other governmental
or public body or authority, or subdivision thereof, binding on Borrower, or (d) the organizational documents of Borrower;

4.6The
execution and delivery by Borrower of this Amendment and the performance by Borrower of its obligations under the Loan Agreement,
as amended by this Amendment, do not require any order, consent, approval, license, authorization or validation of, or filing,
recording or registration with, or exemption by any governmental or public body or authority, or subdivision thereof, binding
on either Borrower, except as already has been obtained or made; and 

    	-3-

    	 

    

 

4.7This Amendment
has been duly executed and delivered by Borrower and is the binding obligation of Borrower, enforceable against Borrower in accordance
with its terms, except as such enforceability may be limited by bankruptcy, insolvency, reorganization, liquidation, moratorium
or other similar laws of general application and equitable principles relating to or affecting creditors’ rights.

 

5.Counterparts.
This Amendment may be executed in any number of counterparts and all of such counterparts taken together shall be deemed to constitute
one and the same instrument.

6.Effectiveness.
This Amendment shall be deemed effective upon (a) the due execution and delivery to Bank of this Amendment by each party hereto
and (b) Borrower’s payment of an amendment fee in an amount equal to $5,000.

7.Governing
Law. This Amendment and the rights and obligations of the parties hereto shall be governed by and construed in accordance with
the laws of the State of California.

[Signature page follows.]

  

    	-4-

    	 

    

 

In
Witness Whereof, the parties hereto have caused this Amendment to be duly executed and delivered
as of the date first written above.

 

 

	BANK	BORROWER
	
         

        Silicon Valley Bank

         

         

        By: _______________________________

        Name:  _____________________________

        Title:  ______________________________
	
         

        Derycz Scientific, Inc.

         

         

        By: ________________________________

        Name:  ______________________________

        Title:  _______________________________

         

	 	BORROWER
	
         

         
	
         

        Reprints Desk, Inc.

         

         

        By: ________________________________

        Name:  ______________________________

        Title:  _______________________________

         

 

    	-5-

    	 

    

 

EXHIBIT C

 

 COMPLIANCE
CERTIFICATE

 

TO:SILICON VALLEY BANK                                                                                                         Date: __________________________

FROM: DERYCZ SCIENTIFIC, INC. on behalf of itself and the other
Borrowers

 

The undersigned authorized officer of
DERYCZ SCIENTIFIC, INC. (“Borrower”) certifies that under the terms and conditions of the Loan and Security Agreement
between Borrowers and Bank (the “Agreement”):

(1) Borrowers are in complete compliance
for the period ending _______________ with all required covenants except as noted below; (2) there are no Events of Default;
(3) all representations and warranties in the Agreement are true and correct in all material respects on this date except
as noted below; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties
that already are qualified or modified by materiality in the text thereof; and provided, further that
those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material
respects as of such date; (4) Borrowers, and each of their Subsidiaries, has timely filed all required tax returns
and reports, and Borrowers have timely paid all foreign, federal, state and local taxes, assessments,
deposits and contributions owed by Borrowers except as otherwise permitted pursuant to the terms of Section 5.9 of the Agreement;
and (5) no Liens have been levied or claims made against any Borrower or any of its Subsidiaries relating to unpaid employee
payroll or benefits of which Borrowers have not previously provided written notification to Bank.

 

Attached are the required documents supporting
the certification. The undersigned certifies that these are prepared in accordance with GAAP consistently applied from one period
to the next except as explained in an accompanying letter or footnotes. The undersigned acknowledges that no borrowings may be
requested at any time or date of determination that Borrowers are not in compliance with any of the terms of the Agreement, and
that compliance is determined not just at the date this certificate is delivered. Capitalized terms used but not otherwise defined
herein shall have the meanings given them in the Agreement.

	Please indicate compliance status by circling Yes/No under “Complies” column.
	 
	Reporting Covenant	Required	Complies
	 	 	 
	Monthly financial statements with 
 Compliance Certificate	Monthly within 30 days	Yes   No
	Annual projections	FYE within 30 days	Yes   No
	10-Q, 10-K and 8-K	Within 5 days after filing with SEC	Yes   No
	A/R & A/P Agings	Monthly within 20 days	Yes   No
	Transaction Report	
        Weekly when not on Streamline,

        Monthly within 20 days when on Streamline

        and with each Advance request
	Yes   No
	 
	
        The following Intellectual Property was registered (or a registration
        application submitted) after the Effective Date

        (if no registrations, state “None”)

        ___________________________________________________________________________________________

        ___________________________________________________________________________________________

         

 

	Financial Covenant	Required	Actual	Complies
	 	 	 	 
	Maintain on a Monthly Basis:	 	 	 
	Minimum Quick Ratio	0.80:1.0	_____:1.0	Yes   No
	Minimum Tangible Net Worth	*	$_________	Yes   No
	 	 	 	 
	*at least (a) $500,000 for each month from January 2012 through August 2012, (b) $750,000 for each month from September 2012 through November 2012 and (c) $1,000,000 for December 2012 and each month ending thereafter plus each of the foregoing increasing by (i) fifty percent (50%) of quarterly Net Income and (ii) fifty percent (50%) of issuances of equity and Subordinated Debt after January 1, 2012.

*

 

    	 

    	 

    

	Streamline Period	Applies
	 	 	 
	Net Cash at least $800,000 at all times	Streamline Period in Effect	Yes   No
	Net Cash less than $800,000 at any time	Streamline Period not in Effect	Yes   No

 

The following financial covenant analyses and information
set forth in Schedule 1 attached hereto are true and accurate as of the date of this Certificate.

The following are the exceptions with respect to the certification
above: (If no exceptions exist, state “No exceptions to note.”)

  

 

 

 

 

 

	
        DERYCZ SCIENTIFIC, INC. on behalf of itself and the other Borrowers

         

         

        By: ______________________________

        Name: ____________________________

        Title: _____________________________

         
	
        BANK USE ONLY

         

        Received by: _____________________

        authorized
        signer

        Date: _________________________

         

        Verified: ________________________

        authorized
        signer

        Date: _________________________

         

        Compliance Status:Yes            No

 

    	 

    	 

    
 

Schedule 1 to Compliance Certificate

 

Financial Covenants of Borrowers

  

In the event of a conflict between this Schedule and the Loan
Agreement, the terms of the Loan Agreement shall govern.

Dated:____________________

 

I.Quick Ratio (Section 6.7(a))

Required:0.80:1.00

 

Actual:

 

	A.	Aggregate
    value of the unrestricted cash of Borrowers	
        $        

	 	 	 
	B.	Aggregate
    value of the net billed accounts receivable of Borrowers	
        $        

	 	 	 
	C.	Quick
    Assets (the sum of lines A and B)	
        $        

	 	 	 
	D.	Aggregate
    value of Obligations to Bank	
        $        

	 	 	 
	E.	Aggregate
    value of liabilities that should, under GAAP, be classified as liabilities on Borrowers’ consolidated balance sheet,
    including all Indebtedness, and not otherwise reflected in line D above that matures within one (1) year	
        $        

	 	 	 
	F.	Current
    Liabilities (the sum of lines D and E)	
        $        

	 	 	 
	G.	Quick
    Ratio (line C divided by line F)	           ______

 

Is line G equal to or greater than 0.80:1:00?

 

           No, not in compliance                                                                  Yes,
in compliance

 

 

     

     

    

 

II.Tangible Net Worth (Section 6.7(b))

 

Required:(a)$500,000 for each month from January 2012
through August 2012;

  (b)$750,000 for each month from
September 2012 through November 2012; and

   (c)$1,000,000 for December 2012 and
each month ending thereafter

 

plus each of the foregoing increasing by (i) fifty percent
(50%) of quarterly Net Income plus (ii) fifty percent (50%) of issuances of equity and Subordinated Debt after the Effective Date.

 

Actual:

 

	A.	Aggregate value of total assets of Borrower and its Subsidiaries	
        $       

         

	B.	Aggregate value of goodwill of Borrower and its Subsidiaries	
        $       

         

	C.	Aggregate value of intangible assets of Borrower and its Subsidiaries	
        $       

         

	D.	Aggregate value of liabilities that should, under GAAP, be classified as liabilities on Borrower’s consolidated balance sheet, including all Indebtedness	
        $       

         

	 	 	 
	E.	Aggregate value of Indebtedness of Borrower subordinated to Borrower’s Indebtedness to Bank	
        $       

         

	F.	Tangible Net Worth (line A minus line B minus line C minus line D plus line E)	
        $       

         

  

Is line F equal to or greater than the applicable Required
Amount?

 

           No, not in compliance                                                                  Yes,
in complianceDEBENTURE AMENDMENT

 

This DEBENTURE AMENDMENT
(this “Amendment”) is dated as of March 17, 2011 by and among Jade Pharmaceuticals. Inc., a British Virgin Islands
corporation (the “Company”), and _________________________________ (the “Holder”). Capitalized terms used
herein and not otherwise defined shall have the meanings ascribed to such terms in the Subscription Agreement (as defined below).

 

RECITALS

 

WHEREAS, the Company entered into a Subscription
Agreement (the “Securities Purchase Agreement”), dated as of February 2, 2011 (the “Closing Date”), pursuant
to which the Company conducted a private offering solely to accredited investors pursuant to Rule 506 of Regulation D of the Securities
Act of 1933, as amended (the “Act”), of its common stock secured by debentures; and

 

WHEREAS, the Company has requested
and the Holder hereby agrees to amend the Debentures as follows:

 

	  1.		Change the conversion date and “Going Public Deadline” date in sections
2(b) and 2(c) from “one year from closing” to September 30, 2011;

 

	2.		Change the aggregate amount of debentures from $1,000,000 to $2,000,000;

 

	3.		Effective Time. The parties hereto agree that this Amendment shall be retroactive
from and including, February 2, 2011.

 

	4.		Effect on Transaction
                                                                              Documents. Except as set forth above the Debenture
                                                                              and any other documents related thereto, shall remain
                                                                              in full force and effect and are hereby ratified
                                                                              and confirmed.

 

	5.		Counterparts. This Amendment may be executed in two or more counterparts, all
of which shall be considered one and the same agreement and shall become effective when counterparts
have been signed by each party and delivered to the other party.

 

	6.		Severability. If any provision of this Amendment shall be invalid or unenforceable
in any jurisdiction, such invalidity or unenforceability shall not affect the validity or enforceability
of the remainder of this Amendment or the validity or enforceability of this Amendment in any other jurisdiction.

 

[REMAINDER OF THIS PAGE
IS INTENTIONALLY LEFT BLANK]

 

[SIGNATURE PAGES OF COMPANY
TO FOLLOW]

 

    	 

    	 

    

 

IN WITNESS WHEREOF, the undersigned have executed
this Amendment as of the date first written above.

  

	 	JADE PHARMACEUTICALS, INC.	 

 

	 	By: 	 	 
	 	Name: Henry Jia	 
	 	Title:   Chief Executive Officer	 

 

[THE REMAINDER OF THIS PAGE IS INTENTIONALLY
LEFT BLANK]

 

[SIGNATURE PAGES OF INVESTORS TO FOLLOW]

 

    	 

    	 

    

 

IN WITNESS WHEREOF, the undersigned have executed
this Amendment as of the date first written above.

 

 

	 	[DEBENTURE HOLDER]	 

 

	 	By: 	 	 
	 	Name:	 
	 	Title:

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