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sec document

                                                                    Exhibit 4.10

                                                        DATED: DECEMBER 28, 2005

     NEITHER THIS  DEBENTURE  NOR THE  SECURITIES  INTO WHICH THIS  DEBENTURE IS
     CONVERTIBLE   HAVE  BEEN   REGISTERED  WITH  THE  SECURITIES  AND  EXCHANGE
     COMMISSION  OR THE  SECURITIES  COMMISSION OF ANY STATE IN RELIANCE UPON AN
     EXEMPTION  FROM  REGISTRATION  UNDER THE SECURITIES ACT OF 1933, AS AMENDED
     (THE "SECURITIES ACT"), AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT
     PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR
     PURSUANT TO AN AVAILABLE  EXEMPTION  FROM, OR IN A TRANSACTION  NOT SUBJECT
     TO, THE  REGISTRATION  REQUIREMENTS OF THE SECURITIES ACT AND IN ACCORDANCE
     WITH APPLICABLE STATE SECURITIES LAWS.

No. CCP-2                                                             $1,000,000

                               CEPTOR CORPORATION

                          SECURED CONVERTIBLE DEBENTURE

                              DUE DECEMBER 28, 2008

     This Secured  Convertible  Debenture (the  "DEBENTURE") is issued by CEPTOR
CORPORATION,   a  Delaware  corporation  (the  "Obligor"),  to  CORNELL  CAPITAL
PARTNERS,  LP (the  "HOLDER"),  pursuant  to that  certain  Securities  Purchase
Agreement (the "SECURITIES PURCHASE AGREEMENT") of even date herewith.

     FOR VALUE RECEIVED, the Obligor hereby promises to pay to the Holder or its
successors  and assigns the  principal sum of One Million  Dollars  ($1,000,000)
together  with accrued but unpaid  interest on or before  December 28, 2008 (the
"MATURITY DATE") in accordance with the following terms:

     INTEREST. Interest shall accrue on the outstanding principal balance hereof
at an annual rate equal to eight percent (8%).  Interest  shall be calculated on
the basis of a 360-day year and the actual number of days elapsed, to the extent
permitted by applicable  law.  Interest  hereunder will be paid to the Holder or
its  assignee  (as  defined  in  Section  5) in whose  name  this  Debenture  is
registered on the records of the Obligor regarding registration and transfers of
Debentures (the "DEBENTURE REGISTER").

     RIGHT OF REDEMPTION.  The Obligor at its option shall have the right,  with
three (3) business days advance  written notice (the  "REDEMPTION  NOTICE"),  to
redeem a portion or all amounts  outstanding  under this Debenture  prior to the
Maturity  Date.  If the  Closing Bid Price of the  Obligor's  Common  Stock,  as
reported  by  Bloomberg,  LP, is less  than the  Fixed  Price at the time of the
Redemption Notice, the Obligor shall pay an amount equal to the principal amount
being  redeemed  plus a redemption  premium  equal to eight  percent (8%) of the
principal amount being redeemed  ("REDEMPTION  PREMIUM"),  and accrued interest,
(collectively referred to as the "REDEMPTION AMOUNT").

                                       1

     In the event the Closing Bid Price of the  Obligor's  Common Stock is above
the Fixed Price at the time of a Redemption  Notice the Obligor can redeem fifty
percent (50%) of the principal  amounts  outstanding under this Debenture at the
Redemption  Amount and the  remaining  fifty percent (50%) at the greater of (i)
the Redemption  Amount and (ii) the market value of this Debenture's  underlying
common stock on an as  converted  basis  utilizing  the Closing Bid Price of the
Company's Common Stock on the day of the Redemption Notice.

     The Obligor shall deliver to the Holder the Redemption  Amount on the third
(3rd) business day after the Redemption Notice.

     Notwithstanding the foregoing, in the event that the Obligor has elected to
redeem a portion of the outstanding  principal amount and accrued interest under
this  Debenture  the Holder  shall be permitted to convert all or any portion of
this Debenture during such three (3) business day period.

     In the event the Obligor  exercises a redemption of either all or a portion
of the outstanding  principal  amounts plus accrued interest due and outstanding
under this debenture as outlined  herein,  the Holder shall receive a warrant to
purchase twenty five thousand  (25,000) shares of the Company's Common Stock for
every  One  Hundred  Thousand  Dollars  ($100,000)  redeemed,   pro  rata.  (the
"WARRANT")  The  Warrant  shall be  exercisable  on a "cash  basis"  and have an
exercise  price of one hundred five  percent  (105%) of the Closing Bid Price of
the Obligor's Common Stock on the Closing Date, as quoted by Bloomberg,  LP, per
share. The Warrant shall have "piggy-back" registration rights and shall survive
for three (3) years from the Closing Date.

     SECURITY AGREEMENTS. This Debenture is secured by a Security Agreement (the
"SECURITY AGREEMENT") of even date herewith between the Obligor and the Holder.

     CONSENT OF HOLDER TO SELL CAPITAL  STOCK OR GRANT  SECURITY  INTERESTS.  So
long  as any  principal  or  interest  on  this  Debenture  remains  unpaid  and
unconverted,  the Obligor shall not,  without the prior  written  consent of the
Holder,  (i)  issue or sell  shares  of  Common  Stock or  Preferred  Stock at a
discount equal to or greater than  twenty-five  percent (25%) of the Closing Bid
Price of the Common Stock determined immediately prior to such issuance or sale,
(ii) issue any warrant,  option,  right,  contract,  call, or other  security or
instrument  granting the holder  thereof the right to acquire  Common Stock at a
discount equal to or greater than  twenty-five  percent (25%) of the Closing Bid
Price of the Common Stock determined  immediately prior to such issuance , (iii)
enter into any security  instrument  granting the holder a security  interest in
any and all assets of the Obligor,  or (iv) file any  registration  statement on
Form S-8 registering more than one million  (1,000,000)  shares of the Company's
Common Stock to be issued  pursuant to the  Company's  bonafide  employee  stock
option plan.

     So long as any principal or interest on this  Debenture  remains unpaid and
unconverted, the Obligor shall not, without five (5) business days prior written
notice to the  Holder,  (i) issue or sell  shares of Common  Stock or  preferred
stock at any discount  less than  twenty-five  percent  (25%) of the Closing Bid
Price of the Common Stock determined immediately prior to such issuance or sale,
or (ii) issue any warrant,  option, right, contract,  call, or other security or
instrument  granting the holder thereof the right to acquire Common Stock at any
discount  less than  twenty-five  percent  (25%) of the Closing Bid Price of the
Common Stock determined immediately prior to such issuance.

                                       2

     Notwithstanding  the above, the Obligor shall not be required to obtain the
consent of the Holder with respect to the Obligor's proposed  stockholder rights
plan (the  "RIGHTS  PLAN") but shall be required  to provide the Holder  written
notice ten (10) days prior to such issuance.

     RIGHTS  OF FIRST  REFUSAL.  So long as any  portion  of this  Debenture  is
outstanding (including principal or accrued interest), if the Obligor intends to
raise  additional  capital  by the  issuance  or sale of  capital  stock  of the
Obligor,  including without  limitation shares of any class of Common Stock, any
class of preferred stock, options,  warrants or any other securities convertible
or exercisable into shares of Common Stock (whether the offering is conducted by
the Obligor, underwriter,  placement agent or any third party) the Obligor shall
be obligated to offer to the Holder ten percent (10%) of such total  issuance or
sale of capital stock,  by providing in writing the principal  amount of capital
it intends to raise and outline of the  material  terms of such  capital  raise,
prior to the  offering  such  issuance  or sale of  capital  stock to any  third
parties including,  but not limited to, current or former officers or directors,
current or former  shareholders  and/or investors of the obligor,  underwriters,
brokers,  agents or other  third  parties,  provided  however the right of first
refusal shall not apply to the Obligor's  current  equity  financing with Fusion
Capital Fund II, LLC ("FUSION  CAPITAL") and the  Obligor's  bonafide 2004 Stock
Incentive  Plan.  The Holder shall have five (5)  business  days from receipt of
such notice of the sale or issuance of capital  stock to accept or reject all or
a portion of such capital raising offer.

     This Debenture is subject to the following additional provisions:

     SECTION 1.     This  Debenture  is  exchangeable  for  an  equal  aggregate
principal  amount  of  Debentures  of  different  authorized  denominations,  as
requested by the Holder  surrendering  the same. No service  charge will be made
for such registration of transfer or exchange.

     SECTION 2.     EVENTS OF DEFAULT.

     (a)  An "EVENT OF  DEFAULT",  wherever  used  herein,  means any one of the
following  events  (whatever  the reason and  whether it shall be  voluntary  or
involuntary or effected by operation of law or pursuant to any judgment,  decree
or order of any court, or any order, rule or regulation of any administrative or
governmental body):

          (i)    Any default in the payment of the principal of,  interest on or
other charges in respect of this Debenture,  free of any claim of subordination,
which  remains  uncured for ten (10)  consecutive  Business  Days after the same
shall have become due and payable  (whether on a Conversion Date or the Maturity
Date or by acceleration or otherwise);

          (ii)   The  Obligor  shall  fail  to  observe  or  perform  any  other
covenant,  agreement or warranty contained in, or otherwise commit any breach or
default of any provision of this Debenture  (except as may be covered by Section
2(a)(i)  hereof) or any  Transaction  Document  (as defined in Section 5) in any
material respect which is not cured within the time prescribed;

                                       3

          (iii)  The Obligor shall commence, or there shall be commenced against
the  Obligor  under  any  applicable  bankruptcy  or  insolvency  laws as now or
hereafter in effect or any successor thereto, or the Obligor commences any other
proceeding under any reorganization,  arrangement, adjustment of debt, relief of
debtors,   dissolution,   insolvency  or  liquidation  or  similar  law  of  any
jurisdiction whether now or hereafter in effect relating to the Obligor or there
is  commenced  against  the  Obligor any such  bankruptcy,  insolvency  or other
proceeding which remains  undismissed for a period of 61 days; or the Obligor is
adjudicated  insolvent  or  bankrupt;  or any  order of  relief  or other  order
approving  any such case or proceeding  is entered;  or the Obligor  suffers any
appointment of any custodian,  private or court  appointed  receiver or the like
for it or any substantial  part of its property which continues  undischarged or
unstayed  for a period of sixty one (61) days;  or the  Obligor  makes a general
assignment  for the benefit of  creditors;  or the Obligor shall fail to pay, or
shall  state  that it is  unable to pay,  or shall be  unable to pay,  its debts
generally  as they  become  due;  or the  Obligor  shall  call a meeting  of its
creditors with a view to arranging a composition, adjustment or restructuring of
its debts; or the Obligor shall by any act or failure to act expressly  indicate
its consent to,  approval of or  acquiescence  in any of the  foregoing;  or any
corporate  or other  action is taken by the Obligor for the purpose of effecting
any of the foregoing;

          (iv)   The Obligor shall default in any of its  obligations  under any
other debenture or any mortgage,  credit agreement or other facility,  indenture
agreement,  factoring  agreement  or other  instrument  under which there may be
issued,  or by which  there may be secured or  evidenced  any  indebtedness  for
borrowed money or money due under any long term leasing or factoring arrangement
of the Obligor in an amount exceeding  $100,000,  whether such  indebtedness now
exists or shall  hereafter  be created  and such  default  shall  result in such
indebtedness  becoming or being  declared  due and payable  prior to the date on
which it would otherwise become due and payable;

          (v)    The Common Stock shall cease to be quoted for trading or listed
for trading on either the Nasdaq OTC Bulletin  Board  ("OTC"),  Nasdaq  SmallCap
Market, New York Stock Exchange,  American Stock Exchange or the Nasdaq National
Market (each, a "SUBSEQUENT MARKET") and shall not again be quoted or listed for
trading thereon within five (5) Trading Days of such delisting;

          (vi)   The  Obligor  shall  be  a  party  to  any  Change  of  Control
Transaction (as defined in Section 5);

          (vii)  The  Obligor   shall  fail  to  file  the   Underlying   Shares
Registration Statement (as defined in Section 5) with the Commission (as defined
in Section 5), or the Underlying  Shares  Registration  Statement shall not have
been declared effective by the Commission,  in accordance with the provisions of
Sections  2(b)  and  2(c)  of  the  Investor   Registration   Rights   Agreement
("REGISTRATION  RIGHTS AGREEMENT") of even date herewith between the Obligor and
the Holder;

                                       4

          (viii) If the  effectiveness  of the  Underlying  Shares  Registration
Statement  lapses for any reason or the Holder  shall not be permitted to resell
the shares of Common Stock underlying this Debenture under the Underlying Shares
Registration  Statement,  in either  case,  for more  than five (5)  consecutive
Trading  Days  or an  aggregate  of  eight  Trading  Days  (which  need  not  be
consecutive Trading Days);

          (ix)   The  Obligor  shall  fail,  due to actions of the  Obligor,  to
deliver Common Stock  certificates  to a Holder prior to the fifth (5th) Trading
Day after a Conversion  Date or the Obligor shall provide  notice to the Holder,
including by way of public  announcement,  at any time,  of its intention not to
comply with requests for  conversions of this  Debenture in accordance  with the
terms hereof;

          (x)    The Obligor shall fail for any reason to deliver the payment in
cash  pursuant to a Buy-In (as defined  herein)  within three (3) Business  Days
after notice is claimed delivered hereunder;

     (b)  During the time that any portion of this Debenture is outstanding,  if
any Event of Default has occurred,  the full principal amount of this Debenture,
together with interest and other amounts owing in respect  thereof,  to the date
of  acceleration  shall become at the  Holder's  election,  immediately  due and
payable in cash,  PROVIDED  HOWEVER,  the Holder may request  (but shall have no
obligation  to request)  payment of such amounts in Common Stock of the Obligor.
In addition to any other remedies,  the Holder shall have the right (but not the
obligation)  to convert this Debenture at any time after (x) an Event of Default
or (y) the Maturity Date at the Conversion Price then in-effect. The Holder need
not provide and the Obligor hereby waives any  presentment,  demand,  protest or
other notice of any kind, and the Holder may immediately and without  expiration
of any grace period enforce any and all of its rights and remedies hereunder and
all other remedies available to it under applicable law. Such declaration may be
rescinded and annulled by Holder at any time prior to payment hereunder. No such
rescission or annulment  shall affect any subsequent  Event of Default or impair
any right  consequent  thereon.  Upon an Event of Default,  notwithstanding  any
other provision of this Debenture or any Transaction Document,  the Holder shall
have no obligation to comply with or adhere to any  limitations,  if any, on the
conversion of this Debenture or the sale of the Underlying Shares.

     SECTION 3.     CONVERSION.

     (a)  CONVERSION AT OPTION OF HOLDER.

          (i)    This Debenture shall be convertible into shares of Common Stock
at the  option of the  Holder,  in whole or in part at any time and from time to
time,  after the  Original  Issue Date (as defined in Section 5) (subject to the
limitations  on  conversion  set forth in Section  3(b)  hereof).  The number of
shares of Common Stock issuable upon a conversion  hereunder equals the quotient
obtained  by  dividing  (x)  the  outstanding  amount  of this  Debenture  to be
converted  by (y) the  Conversion  Price (as  defined in Section  3(c)(i)).  The
Obligor shall use its best efforts to deliver Common Stock  certificates  to the
Holder prior to the Fifth (5th) Trading Day after a Conversion Date.

                                       5

          (ii)   Notwithstanding  anything to the contrary  contained herein, if
on any  Conversion  Date:  (1) the number of shares of Common  Stock at the time
authorized, unissued and unreserved for all purposes, or held as treasury stock,
is  insufficient  to pay  principal  and interest  hereunder in shares of Common
Stock; (2) the Common Stock is not listed or quoted for trading on the OTC or on
a  Subsequent  Market;  (3)  the  Obligor  has  failed  to  timely  satisfy  its
conversion; or (4) the issuance of such shares of Common Stock would result in a
violation of Section 3(b),  then, at the option of the Holder,  the Obligor,  in
lieu of delivering  shares of Common Stock  pursuant to Section  3(a)(i),  shall
deliver,  within three (3) Trading Days of each applicable  Conversion  Date, an
amount in cash equal to the product of the  outstanding  principal  amount to be
converted plus any interest due therein divided by the Conversion Price,  chosen
by the Holder,  and  multiplied  by the highest  closing price of the stock from
date of the conversion notice till the date that such cash payment is made.

     Further, if the Obligor shall not have delivered any cash due in respect of
conversion  of this  Debenture  or as payment of  interest  thereon by the fifth
(5th) Trading Day after the  Conversion  Date,  the Holder may, by notice to the
Obligor, require the Obligor to issue shares of Common Stock pursuant to Section
3(c), except that for such purpose the Conversion Price applicable thereto shall
be the lesser of the Conversion  Price on the Conversion Date and the Conversion
Price on the date of such Holder demand.  Any such shares will be subject to the
provisions of this Section.

          (iii)  The  Holder  shall  effect  conversions  by  delivering  to the
Obligor  a  completed  notice  in the  form  attached  hereto  as  Exhibit  A (a
"CONVERSION NOTICE").  The date on which a Conversion Notice is delivered is the
"CONVERSION  DATE." Unless the Holder is converting the entire  principal amount
outstanding  under this  Debenture,  the Holder is not  required  to  physically
surrender  this  Debenture  to the  Obligor  in  order  to  effect  conversions.
Conversions  hereunder  shall  have  the  effect  of  lowering  the  outstanding
principal  amount of this Debenture plus all accrued and unpaid interest thereon
in an amount  equal to the  applicable  conversion.  The Holder and the  Obligor
shall maintain  records showing the principal  amount  converted and the date of
such conversions.

     (b)  CERTAIN CONVERSION RESTRICTIONS.

          (i)    A Holder may not convert this  Debenture  or receive  shares of
Common Stock as payment of interest  hereunder to the extent such  conversion or
receipt of such interest  payment would result in the Holder,  together with any
affiliate thereof, beneficially owning (as determined in accordance with Section
13(d) of the Exchange  Act and the rules  promulgated  thereunder)  in excess of
4.9% of the then issued and outstanding shares of Common Stock, including shares
issuable upon  conversion of, and payment of interest on, this Debenture held by
such Holder  after  application  of this  Section.  Since the Holder will not be
obligated  to report to the Obligor the number of shares of Common  Stock it may
hold at the time of a conversion hereunder, unless the conversion at issue would
result in the  issuance of shares of Common  Stock in excess of 4.9% of the then
outstanding  shares of Common Stock without regard to any other shares which may
be beneficially  owned by the Holder or an affiliate  thereof,  the Holder shall
have the authority and obligation to determine whether the restriction contained
in this Section will limit any particular conversion hereunder and to the extent
that  the  Holder  determines  that the  limitation  contained  in this  Section
applies,  the  determination  of which portion of the  principal  amount of this

                                       6

Debenture is  convertible  shall be the  responsibility  and  obligation  of the
Holder.  If the Holder has delivered a Conversion  Notice for a principal amount
of this  Debenture  that,  without regard to any other shares that the Holder or
its affiliates may  beneficially  own, would result in the issuance in excess of
the permitted amount hereunder, the Obligor shall notify the Holder of this fact
and shall honor the conversion for the maximum  principal amount permitted to be
converted on such Conversion  Date in accordance  with the periods  described in
Section  3(a)(i) and, at the option of the Holder,  either  retain any principal
amount tendered for conversion in excess of the permitted  amount  hereunder for
future  conversions or return such excess  principal  amount to the Holder.  The
provisions  of this Section may be waived by a Holder (but only as to itself and
not to any other Holder) upon not less than 65 days prior notice to the Obligor.
Other Holders shall be unaffected by any such waiver.

     (c)  CONVERSION PRICE AND ADJUSTMENTS TO CONVERSION PRICE.

          (i)    The Holder shall be entitled to convert, at its sole option, at
any time a portion or all amounts of principal and interest due and  outstanding
under this Debenture into shares of the Obligor's  Common Stock at the lesser of
(i) a price equal to one hundred five percent (105%) of the Closing Bid Price of
the  Obligor's  Common Stock on the day prior to the date  hereof,  as quoted by
Bloomberg,  LP (the  "FIXED  PRICE") or (ii) ninety  five  percent  (95%) of the
lowest  closing  Bid Price of the  Obligor's  Common  Stock for the twenty  (20)
Trading Days  immediately  preceding the Conversion Date as quoted by Bloomberg,
LP.  (the  "FLOATING  Price").  (the  Fixed  Price  and the  Floating  Price are
collectively  referred to as the "CONVERSION PRICE") The Conversion Price may be
adjusted pursuant to the other terms of this Debenture.

     In the event that the Holder is  effectuating  conversion  pursuant  to the
Floating  Price the Holder  shall only be  entitled to convert up to One Hundred
Fifty Thousand  Dollars  ($150,000) of principal due and outstanding  under this
Debenture into shares of the Obligor's  Common Stock in any thirty (30) calendar
day period,  unless  otherwise  waived by the Obligor,  provided  however in the
event the  Obligor  issues or sell  shares of  Common  Stock,  preferred  stock,
warrants,  options,  rights,  contracts,  calls, or other security or instrument
granting the holder thereof the right to acquire Common Stock at any discount of
the Closing Bid Price of the Common Stock  determined  immediately  prior to its
issuance, the Holder shall be entitled to convert without limitation.

          (ii)   If  the   Obligor,   at  any  time  while  this   Debenture  is
outstanding,  shall (a) pay a stock dividend or otherwise make a distribution or
distributions  on  shares  of its  Common  Stock or any  other  equity or equity
equivalent   securities  payable  in  shares  of  Common  Stock,  (b)  subdivide
outstanding  shares of Common Stock into a larger number of shares,  (c) combine
(including  by way of reverse  stock split)  outstanding  shares of Common Stock
into a smaller number of shares, or (d) issue by  reclassification  of shares of
the  Common  Stock any shares of capital  stock of the  Obligor,  then the Fixed
Price  shall be  multiplied  by a fraction of which the  numerator  shall be the
number of shares of Common Stock (excluding treasury shares, if any) outstanding
before such event and of which the denominator  shall be the number of shares of
Common Stock  outstanding after such event. Any adjustment made pursuant to this
Section  shall  become  effective  immediately  after  the  record  date for the
determination of stockholders  entitled to receive such dividend or distribution
and shall become effective immediately after the effective date in the case of a
subdivision, combination or re-classification.

                                       7

          (iii)  If  the   Obligor,   at  any  time  while  this   Debenture  is
outstanding,  shall issue  rights,  options or warrants to all holders of Common
Stock (and not to the Holder) entitling them to subscribe for or purchase shares
of Common Stock,  except  pursuant to the Rights Plan, at a price per share less
than the Fixed Price, then the Fixed Price shall be multiplied by a fraction, of
which  the  denominator  shall be the  number  of  shares  of the  Common  Stock
(excluding  treasury shares, if any) outstanding on the date of issuance of such
rights or warrants (plus the number of additional shares of Common Stock offered
for subscription or purchase), and of which the numerator shall be the number of
shares of the Common Stock (excluding  treasury  shares,  if any) outstanding on
the date of issuance of such rights or warrants, plus the number of shares which
the  aggregate  offering  price of the total  number of shares so offered  would
purchase at the Fixed Price.  Such adjustment shall be made whenever such rights
or warrants are issued, and shall become effective  immediately after the record
date for the  determination  of  stockholders  entitled to receive  such rights,
options or warrants.  However,  upon the expiration of any such right, option or
warrant to purchase shares of the Common Stock the issuance of which resulted in
an  adjustment in the Fixed Price  pursuant to this Section,  if any such right,
option or  warrant  shall  expire and shall not have been  exercised,  the Fixed
Price  shall  immediately  upon such  expiration  be  recomputed  and  effective
immediately  upon such  expiration be increased to the price which it would have
been (but  reflecting any other  adjustments in the Fixed Price made pursuant to
the  provisions  of this Section  after the issuance of such rights or warrants)
had the  adjustment  of the Fixed Price made upon the  issuance of such  rights,
options or  warrants  been made on the basis of  offering  for  subscription  or
purchase only that number of shares of the Common Stock actually  purchased upon
the exercise of such rights, options or warrants actually exercised.

          (iv)   If the Obligor as applicable,  at any time while this Debenture
is outstanding,  shall issue shares of Common Stock or rights, warrants, options
or other securities or debt that are convertible into or exchangeable for shares
of  Common  Stock  ("COMMON  STOCK  EQUIVALENTS")  except  with  respect  to the
Obligor's existing convertible notes with Harbor Trust,  entitling any Person to
acquire  shares of Common Stock,  at a price per share less than the Fixed Price
(if the holder of the Common Stock or Common Stock Equivalent so issued shall at
any time, whether by operation of purchase price adjustments,  reset provisions,
floating  conversion,  exercise  or  exchange  prices  or  otherwise,  or due to
warrants,  options or rights per share which is issued in  connection  with such
issuance,  be  entitled  to receive  shares of Common  Stock to be issued by the
obligor at a price per share which is less than the Fixed Price,  such  issuance
shall be deemed to have  occurred for less than the Fixed  Price),  then, at the
sole  option of the  Holder,  the Fixed  Price  shall be  adjusted to mirror the
conversion,  exchange or purchase  price for such Common  Stock or Common  Stock
Equivalents  (including any reset provisions  thereof) at issue. Such adjustment
shall be made whenever such Common Stock or Common Stock Equivalents are issued.
The Obligor  shall notify the Holder in writing,  no later than two (2) Business
Days  following  the  issuance of any Common  Stock or Common  Stock  Equivalent
subject to this Section, indicating therein the applicable issuance price, or of
applicable  reset price,  exchange  price,  conversion  price and other  pricing
terms.  No adjustment  under this Section shall be made as a result of issuances
and exercises of options,  warrants or stock grants to purchase shares of Common
Stock issued for  compensatory  purposes  pursuant to any of the Obligor's stock
option or stock purchase plans.

          (v)    If  the   Obligor,   at  any  time  while  this   Debenture  is
outstanding,  shall  distribute  to all holders of Common  Stock (and not to the
Holder)  evidences  of its  indebtedness  or assets or  rights  or  warrants  to

                                       8

subscribe for or purchase any  security,  then in each such case the Fixed Price
at which this Debenture shall  thereafter be convertible  shall be determined by
multiplying the Fixed Price in effect immediately prior to the record date fixed
for  determination  of stockholders  entitled to receive such  distribution by a
fraction of which the denominator  shall be the Closing Bid Price  determined as
of the record date  mentioned  above,  and of which the numerator  shall be such
Closing Bid Price on such  record  date less the then fair market  value at such
record  date of the  portion  of such  assets or  evidence  of  indebtedness  so
distributed  applicable  to one (1)  outstanding  share of the  Common  Stock as
determined by the Obligor's Board of Directors in good faith. In either case the
adjustments  shall be  described  in a  statement  provided to the Holder of the
portion  of  assets  or  evidences  of   indebtedness  so  distributed  or  such
subscription rights applicable to one (1) share of Common Stock. Such adjustment
shall be made whenever any such  distribution is made and shall become effective
immediately after the record date mentioned above.

          (vi)   In case of any  reclassification  of the  Common  Stock  or any
compulsory  share exchange  pursuant to which the Common Stock is converted into
other  securities,  cash or  property,  at any  time  while  this  Debenture  is
outstanding,  the Holder shall have the right thereafter to, at its option,  (A)
convert the then  outstanding  principal  amount,  together with all accrued but
unpaid  interest and any other  amounts then owing  hereunder in respect of this
Debenture  into the  shares  of stock and other  securities,  cash and  property
receivable  upon or deemed to be held by holders of the Common  Stock  following
such reclassification or share exchange,  and the Holder of this Debenture shall
be  entitled  upon such  event to receive  such  amount of  securities,  cash or
property as the shares of the Common  Stock of the  Obligor  into which the then
outstanding principal amount,  together with all accrued but unpaid interest and
any other amounts then owing  hereunder in respect of this Debenture  could have
been  converted  immediately  prior to such  reclassification  or share exchange
would have been entitled,  or (B) require the Obligor to prepay the  outstanding
principal amount of this Debenture,  plus all interest and other amounts due and
payable  thereon.  The  entire  prepayment  price  shall be paid in  cash.  This
provision  shall  similarly  apply  to  successive  reclassifications  or  share
exchanges.

          (vii)  The  Obligor  shall  maintain a share  reserve of not less than
five  hundred  percent  (500%)  of the  shares  of Common  Stock  issuable  upon
conversion of this  Debenture;  and within three (3) Business Days following the
receipt  by the  Obligor  of a  Holder's  notice  that  such  minimum  number of
Underlying  Shares is not so  reserved,  the Obligor  shall  promptly  reserve a
sufficient number of shares of Common Stock to comply with such requirement.

          (viii) All  calculations  under this  Section 3 shall be rounded up to
the nearest $0.001 or whole share.

          (ix)   Whenever the Conversion Price is adjusted pursuant to Section 3
hereof, the Obligor shall promptly mail to the Holder a notice setting forth the
Conversion  Price after such  adjustment and setting forth a brief  statement of
the facts requiring such adjustment.

          (x)    If at any time  while this  Debenture  is  outstanding  (A) the
Obligor  shall  declare a  dividend  (or any other  distribution)  on the Common
Stock; (B) the Obligor shall declare a special  nonrecurring cash dividend on or
a redemption of the Common Stock;  (C) the Obligor shall  authorize the granting
to all  holders of the Common  Stock  rights or  warrants  to  subscribe  for or

                                       9

purchase  any  shares  of  capital  stock of any class or of any  rights  except
pursuant to the Rights Plan; (D) the approval of any stockholders of the Obligor
shall be required in connection with any  reclassification  of the Common Stock,
any  consolidation  or  merger  to which  the  Obligor  is a party,  any sale or
transfer  of all or  substantially  all of the  assets  of the  Obligor,  or any
compulsory  share  exchange  whereby the Common  Stock is  converted  into other
securities,  cash or property;  or (E) the Obligor shall authorize the voluntary
or  involuntary  dissolution,  liquidation  or winding up of the  affairs of the
Obligor;  then, in each case, the Obligor shall cause to be filed at each office
or agency maintained for the purpose of conversion of this Debenture,  and shall
cause to be mailed to the Holder at its last address as it shall appear upon the
stock books of the  Obligor,  at least  twenty (20)  calendar  days prior to the
applicable record or effective date hereinafter  specified, a notice stating (x)
the date on which a record  is to be taken  for the  purpose  of such  dividend,
distribution, redemption, rights or warrants, or if a record is not to be taken,
the date as of which the holders of the Common Stock of record to be entitled to
such  dividend,  distributions,   redemption,  rights  or  warrants  are  to  be
determined  or (y)  the  date on  which  such  reclassification,  consolidation,
merger,  sale,  transfer or share  exchange is expected to become  effective  or
close,  and the date as of which it is expected that holders of the Common Stock
of record  shall be entitled to exchange  their  shares of the Common  Stock for
securities,  cash or other  property  deliverable  upon  such  reclassification,
consolidation,  merger,  sale,  transfer or share exchange,  provided,  that the
failure to mail such  notice or any defect  therein  or in the  mailing  thereof
shall not affect the validity of the corporate  action  required to be specified
in such  notice.  The Holder is entitled to convert  this  Debenture  during the
20-day calendar period  commencing the date of such notice to the effective date
of the event triggering such notice.

          (xi)   In case of any (1) merger or  consolidation  of the  Obligor or
any  subsidiary of the Obligor with or into another  Person,  or (2) sale by the
Obligor of more than one-half of the assets of the Obligor in one or a series of
related transactions,  at any time while this Debenture is outstanding, a Holder
shall have the right to (A) exercise any rights under Section 2(b),  (B) convert
the aggregate amount of this Debenture then outstanding into the shares of stock
and other securities,  cash and property receivable upon or deemed to be held by
holders of Common Stock following such merger,  consolidation  or sale, and such
Holder shall be entitled upon such event or series of related  events to receive
such amount of securities,  cash and property as the shares of Common Stock into
which  such  aggregate  principal  amount  of this  Debenture  could  have  been
converted  immediately  prior to such merger,  consolidation or sales would have
been  entitled,  or (C) in the case of a merger or  consolidation,  require  the
surviving entity to issue to the Holder a convertible Debenture with a principal
amount equal to the aggregate  principal  amount of this  Debenture then held by
such  Holder,  plus all  accrued and unpaid  interest  and other  amounts  owing
thereon,  which  such  newly  issued  convertible  Debenture  shall  have  terms
identical (including with respect to conversion) to the terms of this Debenture,
and shall be entitled to all of the rights and  privileges of the Holder of this
Debenture set forth herein and the agreements  pursuant to which this Debentures
were issued.  In the case of clause (C), the conversion price applicable for the
newly issued shares of convertible  preferred  stock or  convertible  Debentures
shall be based upon the amount of securities,  cash and property that each share
of Common Stock would receive in such  transaction  and the Conversion  Price in
effect  immediately  prior  to  the  effectiveness  or  closing  date  for  such
transaction.  The terms of any such merger,  sale or consolidation shall include
such  terms so as to  continue  to give the  Holder  the  right to  receive  the
securities,  cash and property set forth in this Section upon any  conversion or
redemption  following  such  event.  This  provision  shall  similarly  apply to
successive such events.

                                       10

     (d)  OTHER PROVISIONS.

          (i)    The  Obligor  covenants  that it will at all times  reserve and
keep available out of its authorized and unissued  shares of Common Stock solely
for the purpose of issuance  upon  conversion  of this  Debenture and payment of
interest on this Debenture, each as herein provided, free from preemptive rights
or any other actual contingent purchase rights of persons other than the Holder,
not less than such number of shares of the Common Stock as shall (subject to any
additional  requirements  of the  Obligor as to  reservation  of such shares set
forth in this  Debenture) be issuable  (taking into account the  adjustments and
restrictions  of Sections 2(b) and 3(c)) upon the conversion of the  outstanding
principal  amount of this  Debenture  and  payment of  interest  hereunder.  The
Obligor  covenants  that all shares of Common  Stock  that shall be so  issuable
shall,  upon  issue,  be duly and  validly  authorized,  issued and fully  paid,
nonassessable  and, if the  Underlying  Shares  Registration  Statement has been
declared  effective  under the  Securities  Act,  registered  for public sale in
accordance with such Underlying Shares Registration Statement.

          (ii)   Upon a conversion  hereunder  the Obligor shall not be required
to issue  stock  certificates  representing  fractions  of shares of the  Common
Stock,  but may if  otherwise  permitted,  make a cash payment in respect of any
final  fraction of a share  based on the Closing Bid Price at such time.  If the
Obligor elects not, or is unable, to make such a cash payment,  the Holder shall
be  entitled  to receive,  in lieu of the final  fraction of a share,  one whole
share of Common Stock.

          (iii)  The issuance of certificates  for shares of the Common Stock on
conversion of this Debenture  shall be made without charge to the Holder thereof
for any documentary stamp or similar taxes that may be payable in respect of the
issue or delivery of such  certificate,  provided  that the Obligor shall not be
required to pay any tax that may be payable in respect of any transfer  involved
in the issuance and delivery of any such  certificate  upon conversion in a name
other than that of the Holder of such  Debenture  so  converted  and the Obligor
shall not be required to issue or deliver such certificates  unless or until the
person or persons requesting the issuance thereof shall have paid to the Obligor
the  amount of such tax or shall have  established  to the  satisfaction  of the
Obligor that such tax has been paid.

          (iv)   Nothing  herein shall limit a Holder's  right to pursue  actual
damages  or declare  an Event of  Default  pursuant  to Section 2 herein for the
Obligor 's failure to deliver  certificates  representing shares of Common Stock
upon conversion within the period specified herein and the Holder shall have the
right to pursue  all  remedies  available  to it at law or in equity  including,
without limitation,  a decree of specific  performance and/or injunctive relief.
The  exercise of any such rights  shall not  prohibit the Holder from seeking to
enforce damages pursuant to any other Section hereof or under applicable law.

          (v)    In addition to any other rights available to the Holder, if the
Obligor fails to deliver to the Holder such certificate or certificates pursuant
to  Section  3(a)(i),  and if after  such  fifth  (5th)  Trading  Day the Holder
purchases (in an open market  transaction or otherwise)  Common Stock to deliver
in  satisfaction  of a sale by such Holder of the  Underlying  Shares  which the
Holder anticipated receiving upon such conversion (a "BUY-IN"), then the Obligor
shall (A) pay in cash to the Holder (in addition to any remedies available to or
elected by the Holder) the amount by which (x) the Holder's total purchase price

                                       11

(including  brokerage  commissions,  if any) for the Common  Stock so  purchased
exceeds (y) the product of (1) the  aggregate  number of shares of Common  Stock
that such Holder  anticipated  receiving from the conversion at issue multiplied
by (2) the market  price of the Common Stock at the time of the sale giving rise
to such purchase obligation and (B) at the option of the Holder,  either reissue
a  Debenture  in the  principal  amount  equal to the  principal  amount  of the
attempted  conversion  or  deliver  to the Holder the number of shares of Common
Stock that  would have been  issued had the  Obligor  timely  complied  with its
delivery  requirements  under  Section  3(a)(i).  For  example,  if  the  Holder
purchases  Common  Stock  having a total  purchase  price of  $11,000 to cover a
Buy-In with respect to an attempted  conversion  of  Debentures  with respect to
which the market price of the Underlying  Shares on the date of conversion was a
total of $10,000 under clause (A) of the  immediately  preceding  sentence,  the
Obligor shall be required to pay the Holder $1,000. The Holder shall provide the
Obligor  written notice  indicating the amounts payable to the Holder in respect
of the Buy-In.

     SECTION 4.     NOTICES.   Any   notices,   consents,   waivers   or   other
communications  required or permitted to be given under the terms hereof must be
in writing and will be deemed to have been  delivered:  (i) upon  receipt,  when
delivered  personally;  (ii)  upon  receipt,  when sent by  facsimile  (provided
confirmation of transmission  is  mechanically or  electronically  generated and
kept on file by the sending  party);  or (iii) one (1) Trading Day after deposit
with a nationally  recognized  overnight delivery service, in each case properly
addressed to the party to receive the same. The addresses and facsimile  numbers
for such communications shall be:

If to the Company, to:     CepTor Corporation
                           200 International Circle - Suite 5100
                           Hunt Valley, MD 21030
                           Attention: Donald W. Fallon
                           Telephone: (410) 527-9998
                           Facsimile: (410) 527-9867

With a copy to:            Olshan Grundman Frome Rosenzweig & Wolosky LLP
                           Park Avenue Tower
                           65 East 55th Street
                           New York, NY 10022
                           Attention: Harvey J. Kesner, Esq.
                           Telephone: (212) 451-2259
                           Facsimile: (212) 451-2222

If to the Holder:          Cornell Capital Partners, LP
                           101 Hudson Street, Suite 3700
                           Jersey City, NJ  07303
                           Attention: Mark Angelo
                           Telephone: (201) 985-8300

                                       12

With a copy to:            David Gonzalez, Esq.
                           101 Hudson Street - Suite 3700
                           Jersey City, NJ 07302
                           Telephone: (201) 985-8300
                           Facsimile: (201) 985-8266

or at such other address and/or facsimile number and/or to the attention of such
other person as the  recipient  party has  specified by written  notice given to
each other  party three (3)  Business  days prior to the  effectiveness  of such
change.  Written  confirmation  of receipt  (i) given by the  recipient  of such
notice,   consent,   waiver  or  other   communication,   (ii)  mechanically  or
electronically  generated by the sender's facsimile machine containing the time,
date,  recipient  facsimile  number  and an  image  of the  first  page  of such
transmission  or (iii) provided by a nationally  recognized  overnight  delivery
service, shall be rebuttable evidence of personal service,  receipt by facsimile
or receipt from a nationally recognized overnight delivery service in accordance
with clause (i), (ii) or (iii) above, respectively.

     SECTION 5.     DEFINITIONS.  For the purposes  hereof,  the following terms
shall have the following meanings:

     "BUSINESS  DAY"  means any day  except  Saturday,  Sunday and any day which
shall be a federal  legal holiday in the United States or a day on which banking
institutions  are  authorized or required by law or other  government  action to
close.

     "CHANGE OF CONTROL  TRANSACTION" means the occurrence of (a) an acquisition
after the date hereof by an  individual or legal entity or "group" (as described
in Rule  13d-5(b)(1)  promulgated  under the Exchange Act) of effective  control
(whether through legal or beneficial  ownership of capital stock of the Obligor,
by  contract or  otherwise)  of in excess of fifty  percent  (50%) of the voting
securities of the Obligor (except that the  acquisition of voting  securities by
the Holder  shall not  constitute a Change of Control  Transaction  for purposes
hereof), (b) a replacement at one time or over time of more than one-half of the
members of the board of  directors  of the  Obligor  which is not  approved by a
majority of those  individuals  who are members of the board of directors on the
date hereof (or by those  individuals who are serving as members of the board of
directors on any date whose nomination to the board of directors was approved by
a majority of the members of the board of directors  who are members on the date
hereof), or (c) the merger, consolidation or sale of fifty percent (50%) or more
of the assets of the Obligor or any subsidiary of the Obligor in one or a series
of related transactions with or into another entity,.

     "COMMISSION" means the Securities and Exchange Commission.

     "COMMON STOCK" means the common stock,  par value  $0.0001,  of the Obligor
and stock of any other class into which such shares may  hereafter be changed or
reclassified.

     "CONVERSION  DATE"  shall  mean the date upon  which the  Holder  gives the
Obligor  notice of their  intention to effectuate a conversion of this Debenture
into shares of the Company's Common Stock as outlined herein.

                                       13

     "CLOSING BID PRICE" means the price per share in the last reported trade of
the Common  Stock on the OTC or on the  exchange  which the Common Stock is then
listed as quoted by Bloomberg, LP.

     "EXCHANGE ACT" means the Securities Exchange Act of 1934, as amended.

     "ORIGINAL  ISSUE  DATE"  shall mean the date of the first  issuance of this
Debenture  regardless of the number of transfers and regardless of the number of
instruments, which may be issued to evidence such Debenture.

     "PERSON" means a corporation,  a limited liability company, an association,
a  partnership,  organization,  a  business,  an  individual,  a  government  or
political subdivision thereof or a governmental agency.

     "SECURITIES  ACT" means the  Securities  Act of 1933,  as amended,  and the
rules and regulations promulgated thereunder.

     "TRADING DAY" means a day on which the shares of Common Stock are quoted on
the OTC or quoted or traded  on such  Subsequent  Market on which the  shares of
Common  Stock are then  quoted or listed;  provided,  that in the event that the
shares of Common  Stock are not listed or quoted,  then Trading Day shall mean a
Business Day.

     "TRANSACTION  DOCUMENTS"  means the  Securities  Purchase  Agreement or any
other agreement  delivered in connection with the Securities Purchase Agreement,
including,  without limitation, the Security Agreement, the Irrevocable Transfer
Agent Instructions, and the Registration Rights Agreement.

     "UNDERLYING  SHARES"  means  the  shares  of  Common  Stock  issuable  upon
conversion of this  Debenture or as payment of interest in  accordance  with the
terms hereof.

     "UNDERLYING SHARES REGISTRATION  STATEMENT" means a registration  statement
meeting  the  requirements  set  forth  in the  Registration  Rights  Agreement,
covering among other things the resale of the  Underlying  Shares and naming the
Holder as a "selling stockholder" thereunder.

     SECTION 6.     Except as expressly  provided  herein,  no provision of this
Debenture  shall  alter or impair  the  obligations  of the  Obligor,  which are
absolute and unconditional,  to pay the principal of, interest and other charges
(if any) on, this  Debenture at the time,  place,  and rate,  and in the coin or
currency,  herein  prescribed.  This  Debenture  is a direct  obligation  of the
Obligor.  This  Debenture  ranks  pari passu  with all other  Debentures  now or
hereafter issued under the terms set forth herein.  As long as this Debenture is
outstanding, the Obligor shall not, without the consent of the Holder, (i) amend
its  certificate of  incorporation,  bylaws or other charter  documents so as to
adversely  affect any rights of the Holder;  (ii) repay,  repurchase or offer to
repay,  repurchase  or  otherwise  acquire  shares of its Common  Stock or other
equity securities other than as to the Underlying Shares to the extent permitted
or required under the Transaction  Documents;  or (iii) enter into any agreement
with respect to any of the foregoing.

     SECTION 7.     This  Debenture  shall not  entitle the Holder to any of the
rights of a stockholder of the Obligor,  including without limitation, the right
to vote, to receive dividends and other distributions,  or to receive any notice

                                       14

of, or to attend,  meetings  of  stockholders  or any other  proceedings  of the
Obligor,  unless  and to the extent  converted  into  shares of Common  Stock in
accordance with the terms hereof.

     SECTION 8.     If this Debenture is mutilated,  lost,  stolen or destroyed,
the Obligor shall execute and deliver, in exchange and substitution for and upon
cancellation of the mutilated Debenture,  or in lieu of or in substitution for a
lost, stolen or destroyed Debenture, a new Debenture for the principal amount of
this Debenture so mutilated,  lost, stolen or destroyed but only upon receipt of
evidence  of such  loss,  theft or  destruction  of such  Debenture,  and of the
ownership hereof, and indemnity,  if requested,  all reasonably  satisfactory to
the Obligor.

     SECTION 9.     No  indebtedness  of the Obligor is senior to this Debenture
in  right  of  payment,  whether  with  respect  to  interest,  damages  or upon
liquidation  or  dissolution  or otherwise.  Without the Holder's  consent,  the
Obligor will not, directly or indirectly,  enter into, create,  incur, assume or
suffer to exist any  indebtedness  of any kind, on or with respect to any of its
property or assets now owned or hereafter  acquired or any  interest  therein or
any income or profits therefrom that is senior in any respect to the obligations
of the Obligor under this Debenture.

     SECTION 10.    This  Debenture  shall  be  governed  by  and  construed  in
accordance  with the laws of the State of  Delaware,  without  giving  effect to
conflicts of laws thereof.  Each of the parties  consents to the jurisdiction of
the Superior  Courts of the State of New Jersey  sitting in Hudson  County,  New
Jersey and the U.S.  District  Court for the  District of New Jersey  sitting in
Newark,  New Jersey in connection  with any dispute arising under this Debenture
and hereby  waives,  to the maximum  extent  permitted  by law,  any  objection,
including  any  objection  based on FORUM NON  CONVENIENS to the bringing of any
such proceeding in such jurisdictions.

     SECTION 11.    If the Obligor  fails to  strictly  comply with the terms of
this  Debenture,  then the Obligor shall  reimburse the Holder  promptly for all
fees, costs and expenses,  including, without limitation,  reasonable attorneys'
fees and expenses  reasonably incurred by the Holder in any action in connection
with this Debenture,  including,  without limitation, those incurred: (i) during
any workout, attempted workout, and/or in connection with the rendering of legal
advice as to the Holder's rights, remedies and obligations,  (ii) collecting any
sums  which  become  due to the  Holder,  (iii)  defending  or  prosecuting  any
proceeding  or any  counterclaim  to any  proceeding  or  appeal;  or  (iv)  the
protection, preservation or enforcement of any rights or remedies of the Holder.

     SECTION 12.    Any  waiver by the  Holder of a breach of any  provision  of
this Debenture  shall not operate as or be construed to be a waiver of any other
breach  of such  provision  or of any  breach  of any  other  provision  of this
Debenture. The failure of the Holder to insist upon strict adherence to any term
of this Debenture on one or more  occasions  shall not be considered a waiver or
deprive that party of the right  thereafter  to insist upon strict  adherence to
that term or any other term of this Debenture. Any waiver must be in writing.

     SECTION 13.    If any  provision of this  Debenture is invalid,  illegal or
unenforceable,  the balance of this Debenture shall remain in effect, and if any
provision is inapplicable to any person or circumstance,  it shall  nevertheless
remain applicable to all other persons and  circumstances.  If it shall be found

                                       15

that any interest or other amount deemed  interest due  hereunder  shall violate
applicable laws governing  usury,  the applicable rate of interest due hereunder
shall  automatically be lowered to equal the maximum permitted rate of interest.
The Obligor  covenants  (to the extent that it may lawfully do so) that it shall
not at any time insist upon,  plead, or in any manner  whatsoever  claim or take
the benefit or advantage of, any stay, extension or usury law or other law which
would  prohibit  or forgive  the  Obligor  from paying all or any portion of the
principal of or interest on this  Debenture  as  contemplated  herein,  wherever
enacted,  now or at any time  hereafter  in  force,  or  which  may  affect  the
covenants or the performance of this  indenture,  and the Obligor (to the extent
it may lawfully do so) hereby  expressly waives all benefits or advantage of any
such law,  and  covenants  that it will not, by resort to any such law,  hinder,
delay or impeded the  execution of any power herein  granted to the Holder,  but
will  suffer and permit  the  execution  of every such as though no such law has
been enacted.

     SECTION 14.    Whenever any payment or other obligation  hereunder shall be
due on a day other than a Business  Day,  such payment shall be made on the next
succeeding Business Day.

     SECTION 15.    THE PARTIES HEREBY KNOWINGLY,  VOLUNTARILY AND INTENTIONALLY
WAIVE  THE  RIGHT  ANY OF THEM  MAY HAVE TO A TRIAL  BY JURY IN  RESPECT  OF ANY
LITIGATION  BASED  HEREON OR ARISING OUT OF,  UNDER OR IN  CONNECTION  WITH THIS
AGREEMENT  OR ANY  TRANSACTION  DOCUMENT  OR ANY  COURSE OF  CONDUCT,  COURSE OF
DEALING,  STATEMENTS  (WHETHER VERBAL OR WRITTEN) OR ACTIONS OF ANY PARTY.  THIS
PROVISION  IS  A  MATERIAL  INDUCEMENT  FOR  THE  PARTIES'  ACCEPTANCE  OF  THIS
AGREEMENT.

                   [REMAINDER OF PAGE INTENTIONLLY LEFT BLANK]

                                       16

     IN WITNESS  WHEREOF,  the  Obligor  has  caused  this  Secured  Convertible
Debenture to be duly  executed by a duly  authorized  officer as of the date set
forth above.

                                       CEPTOR CORPORATION

                                       By: /s/ William Pursley
                                           -------------------------------------
                                       Name:  William .
Pursley
                                       Title: Chief Executive Officer

                                       17

                                   EXHIBIT "A"

                              NOTICE OF CONVERSION

        (TO BE EXECUTED BY THE HOLDER IN ORDER TO CONVERT THE DEBENTURE)

TO:

     The undersigned hereby irrevocably elects to convert  $_________________ of
the  principal  amount of the above  Debenture  into  Shares of Common  Stock of
CepTor  Corporation,  according  to the  conditions  stated  therein,  as of the
Conversion Date written below.

CONVERSION DATE:                          ______________________________________

APPLICABLE CONVERSION PRICE:              ______________________________________

SIGNATURE:                                ______________________________________

NAME:                                     ______________________________________

ADDRESS:                                  ______________________________________

AMOUNT TO BE CONVERTED:                   $_____________________________________

AMOUNT OF DEBENTURE
UNCONVERTED:                              $_____________________________________

CONVERSION PRICE PER SHARE:               $_____________________________________

NUMBER OF  SHARES OF COMMON
STOCK TO BE ISSUED:                       ______________________________________

PLEASE ISSUE THE SHARES OF
COMMON STOCK IN THE FOLLOWING
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ISSUE TO:                                 ______________________________________

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ACCOUNT NUMBER:                           ______________________________________exv10w1

 

EXHIBIT
10.1
CONFIDENTIAL

CERTAIN MATERIAL (INDICATED BY AN ASTERISK) HAS BEEN OMITTED FROM THIS DOCUMENT PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT. THE OMITTED MATERIAL HAS BEEN FILED
SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION.

AMENDMENT NO. 1 TO

COLLABORATION AND LICENSE AGREEMENT

     This AMENDMENT NO. 1 TO COLLABORATION AND LICENSE AGREEMENT (this “Amendment”),
effective as of January 1, 2005 (the “Amendment Effective Date”), is made by and between
CancerVax Corporation, a Delaware corporation having its principal office at 2110 Rutherford Road,
Carlsbad, California, 92008, USA (“CancerVax”), and Serono Technologies S.A., a Swiss
corporation having its principal office at Zone Industrielle de l’Ouriettaz, 1170 Aubonne,
Switzerland (“Serono”). CancerVax and Serono may each be referred to as a “Party”
or together, the “Parties”.

RECITALS

     WHEREAS, the Parties entered into that certain Collaboration and License Agreement dated as of
December 15, 2004 (the “Agreement”; capitalized terms used and not otherwise defined in
this Amendment are used as defined in the Agreement), which set forth, among other things, the
Parties’ agreement in respect of the sharing of certain Development Expenses and Commercialization
Expenses; and

     WHEREAS, the Parties wish to amend the basis on which certain Development Expenses and
Commercialization Expenses are calculated.

     NOW, THEREFORE, in consideration of the foregoing premises and the representations, covenants
and agreements contained herein, CancerVax and Serono, intending to be legally bound, hereby agree
as follows:

	1.	 	Amendment to Definition of Commercial Expenses. Section 1.18.1 of the Agreement is
hereby amended and restated in its entirety as follows:

	 	1.18.1	 	internal marketing, scientific, medical, technical or managerial personnel engaged
in such efforts, which costs shall be documented and based on the Commercial FTE Rate,
unless another basis is otherwise agreed by the Steering Committee in writing; for the
sake of clarity, the Parties agree that costs attributable to persons whose salaries
or other costs or expenses can be included in Allocable Overhead shall not be
calculated at the Commercial FTE Rate.

	2.	 	New Definition: Commercial FTE Rate. The following is hereby inserted into the
Agreement as new Section 1.18A, to follow Section 1.18 and precede Section 1.19:

	 	1.18A	 	“Commercial FTE Rate” means [***] U.S. dollars (U.S. $[***]) per
full time equivalent personnel. Such rate shall be adjusted as provided in Section
6.2.9A.

***Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted portions.

 

 

	3.	 	New Section 1.18.1A. The following is hereby inserted into the Agreement as a new
Section 1.18.1A to follow Section 1.18.1 and precede Section 1.18.2:

	 	1.18.1A	 	additional support personnel engaged in such efforts who are not included within
the definition of Section 1.18.1, including but not limited to administrative support
personnel, which costs shall be documented and based on each such individual’s actual
applicable FTE Costs (as opposed to on an averaged basis) to Serono or CancerVax,
respectively, for the relevant period;

	4.	 	New Section 1.29.1A. The following is hereby inserted into the Agreement as a new
Section 1.29.1A to follow Section 1.29.1 and precede Section 1.29.2:

	 	1.29.1A	 	additional support personnel engaged in such efforts who are not included within
the definition of Section 1.29.1, including but not limited to administrative support
personnel, which costs shall be documented and based on each such individual’s actual
applicable FTE Costs (as opposed to on an averaged basis) to Serono or CancerVax,
respectively, for the relevant period;

	5.	 	New Definition: Development FTE Rate. The following is hereby inserted into the
Agreement as a new Section 1.29A, to follow Section 1.29 and precede Section 1.30:

	 	1.29A	 	“Development FTE Rate” means [***] U.S. dollars (U.S. $[***]) per
full time equivalent personnel. Such rate shall be adjusted as provided in Section
4.5.3. Notwithstanding the foregoing, the Parties agree that the Development FTE Rate
applicable to Development Costs incurred by CancerVax pursuant to Section 1.29.1 prior
to January 1, 2005 shall be [***] U.S. dollars (U.S. $[***]) per full time equivalent
personnel.

	6.	 	Amendment to Definition of Development Expenses. Section 1.29.1 of the Agreement is
hereby amended and restated in its entirety as follows:

	 	1.29.1	 	internal scientific, medical, technical or managerial personnel engaged in such
efforts, which costs shall be documented and based on the Development FTE Rate, unless
another basis is otherwise agreed by the Parties in writing; for the sake of clarity,
the Parties agree that costs attributable to persons whose salaries or other costs or
expenses can be included in Allocable Overhead shall not be calculated at the
Development FTE Rate.

	7.	 	Amendment to Definition of Shared Expenses. Section 1.32 of the Agreement is
hereby amended by adding the following at the end of such Section:

2

***Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted portions.

 

		 	For the sake of clarity, no expenses related to stock options or stock grants shall be
included in Shared Expenses.

	8.	 	New Definition: FTE Costs. The following is hereby inserted into the Agreement as a
new Section 1.37A, to follow Section 1.37 and precede Section 1.38:

	 	1.37A	 	“FTE Costs” means the aggregate of the following costs, calculated
on a per full time equivalent personnel basis: [***].

	9.	 	Amendment to Net Sales Definition: Section 1.50.4 of the Agreement is hereby amended
and restated in its entirety as follows:

	 	1.50.4	 	with respect to aggregate amounts billed or invoiced to customers by or on
behalf of Serono in the ROW only, amounts debited on account of bad debt with
respect to amounts previously invoiced. For the avoidance of doubt, bad debt
resulting from sales of the Product in the U.S. shall be borne solely by
CancerVax.

	10.	 	Amendment to Changes to Development Plan. Section 4.3.3 of the Agreement is hereby
amended by adding the following sentence to the end of this Section:

In addition, without the prior approval of the SC (without reference to Article
16), neither Party shall be responsible for sharing any incurred Development
Expenses of the other Party for the Calendar Year in question that exceed by
greater than five percent (5%) the amount approved by the SC to be incurred by such
Party for such Calendar Year, notwithstanding any adjustment made to the Development FTE Rate during that
year, and any such unapproved excess Development Expenses incurred by a Party shall
be borne solely by such Party and the fourth Calendar Quarter reconciliation, as
contemplated under Section 9.5.4, shall be made accordingly.

	11.	 	Amendment to Changes to Commercialization Plan. Section 6.2.3 of the
Agreement is hereby amended by adding the following sentence after the first
sentence of this Section:

3

***Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted portions.

 

In addition, without the prior approval of the SC (without reference to Article
16), neither Party shall be responsible for sharing any incurred Commercial
Expenses of the other Party for the Calendar Year in question that exceed by
greater than five percent (5%) the amount approved by the SC to be incurred by such
Party such Calendar Year, notwithstanding any adjustment made to the Commercial FTE
Rate during that year, and any such unapproved excess Commercial Expenses incurred
by a Party shall be borne solely by such Party and the fourth Calendar Quarter
reconciliation, as contemplated under Section 9.5.4, shall be made accordingly.

	12.	 	Amendment to Reconciliation Payment. Section 9.5.5 of the Agreement is hereby
amended by adding the following after the first sentence of this Section:

Serono will collect, on CancerVax’s behalf, and transfer to CancerVax’s account on
a periodic basis (to be agreed upon between the Parties) all amounts resulting from
sales of the Product in the U.S. Any amounts not collected from customers in the
U.S. due to bad debt shall not be compensated by Serono to CancerVax, and CancerVax
shall be responsible for all risk and costs associated with bad debt in the U.S.

	13.	 	Governing Law. This Amendment shall be construed, and the respective rights of the
Parties determined, according to the substantive Laws of the State of New York notwithstanding
the provisions governing conflict of Laws thereunder to the contrary, except matters of
intellectual property which shall be determined in accordance with U.S. federal patent Laws or
the intellectual property Laws relevant to the intellectual property in question. The
UNCITRAL Convention for the International Sale of Goods, as well as any other unified Laws
relating to the conclusion and implementation of contracts for the international sale of
goods, shall not apply.

	14.	 	Counterparts; Fax Signatures. This Amendment may be executed in any two (2)
counterparts, including by facsimile, each of which, when executed, shall be deemed to be an
original and both of which together shall constitute one and the same document.

	15.	 	Full Force and Effect. Except as set forth in this Amendment, the Agreement shall
remain in full force and effect.

[Signature Page Follows]

4

 

     IN WITNESS WHEREOF, CancerVax and Serono, by their duly authorized officers, have executed
this Amendment as of the dates set forth below, to be effective as of the Amendment Effective Date.

	 	 	 
	CANCERVAX CORPORATION

	 	SERONO TECHNOLOGIES S.A.

	 	 	 	 	 	 	 
	By:

	 	     /s/ David F. Hale
	 	By:
	 	     /s/ Leon Bushara
	 

	 	 
	 	 	 	 
	 

	 	     Name: David F. Hale
	 	 	 	     Name: Leon Bushara
	 

	 	     Title: President & CEO
	 	 	 	     Title: Authorized Representative

	 	 	 	 	 
	 

	 	Date: December 22, 2005
	 	Date: December 21, 2005

	 	 	 	 	 	 	 
	 

	 	 
	 	     By: :
	 	     /s/ Frank Latrille
	 

	 	 	 	 	 	 
	 

	 	 	 	 	 	     Name: Frank Latrille
	 

	 	 	 	 	 	     Title: Authorized Representative

	 	 	 
	 

	 	Date: December 21, 2005

[Signature Page to Amendment No. 1

to Collaboration and License Agreement]

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