Document:

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                                                                    EXHIBIT 10.8

                     Amendment Four to Consulting Agreement

        WHEREAS, this Amendment Four to Consulting Agreement is effective July
1, 2000, and is made between NEORX CORPORATION, 410 West Harrison Street,
Seattle, Washington 98119, and DR. FRED CRAVES, 215 Laurel Grove, Kentfield,
California 94904; and

        WHEREAS, the parties are desirous of extending the term of said
Consulting Agreement.

        NOW, THEREFORE, the term of the Agreement shall be extended to December
31, 2000.

        All other terms and conditions of the original Consulting Agreement as
amended shall remain in full force and effect, as stated.

                                              NeoRx Corporation

                                              By: /s/ PAUL G. ABRAMS
                                                  ------------------------------
                                                      Paul G. Abrams, M.D., J.D.
                                                      Chief Executive Officer

                                              /s/ FRED B. CRAVES
                                              ----------------------------------
                                              Fred B. Craves, Ph.D.<PAGE>   1
                                                                   Exhibit 10.10

                                 AMENDMENT NO. 4

                                     to the

                                License Agreement

                             Effective June 1, 1987

                                     Between

                               STANFORD UNIVERSITY

                                       and

                                NEORX CORPORATION

        Effective as of July 11, 1997, THE BOARD OF TRUSTEES OF THE LELAND
STANFORD JUNIOR UNIVERITY, a body having corporate powers under the laws of the
State of California ("STANFORD") and NEORX CORPORATION, a Washington
Corporation, having a principal place of business at 410 W. Harrison, Seattle,
Washington 98119 ("NEORX"), agree as follows:

                                    AMENDMENT

        2.3 - Paragraph 12.3(a) of the License is hereby amended to read in its
entirety, as follows:

        12.3 (a) - Sublicense terms and conditions shall reflect that any
        sublicensee shall not further sublicense; provided, however, that
        NEORX's proposed sublicensee, JANSSEN PHARMACEUTICA, may further
        sublicense provided that notification is sent to STANFORD upon signing
        of the sublicense and that any sub-sublicensee may not further
        sublicense; and

        IN WITNESS WHEREOF, the parties hereto have executed this Amendment No.
4 in duplicate originals by their duly authorized officers or representatives.

THE BOARD OF TRUSTEES                         NEORX CORPORATION
OF THE LELAND STANFORD
JUNIOR UNIVERSITY

By      /s/ [SIGNATURE ILLEGIBLE]             By     /s/ PAUL G. ABRAMS
        --------------------------------             ---------------------------

Title   Director Technology Licensing         Title  President & CEO
        --------------------------------             ---------------------------

Date    July 15, 1997                         Date   7/11/97
        --------------------------------             ---------------------------<PAGE>   1
                                                                   EXHIBIT 10.20
                               NEORX CORPORATION
                   NONQUALIFIED STOCK OPTION LETTER AGREEMENT
                                DECEMBER 19, 2000

TO:  CARL S. GOLDFISCHER

We are pleased to inform you that you have been granted a nonqualified stock
option under the NeoRx Corporation Restated 1994 Stock Option Plan (the "Plan")
for the purchase of 10,000 shares of NeoRx Corporation's (the "Company") common
stock at an exercise price of $6.25 per share, pursuant to the terms and
conditions set forth below and in the Company Plan. A copy of the Plan is
attached and incorporated into this Agreement by reference.

The terms of the option are as set forth in the Plan and in this Agreement. The
most important of the terms set forth in the Plan are summarized as follows:

        DATE OF GRANT: The date of grant of the option is December 19, 2000.

        VESTING: The option shall vest and become exercisable, subject to
shareholder approval of the Plan, in accordance with the following schedule:

               Date On and After Which             Portion of Total Option
                Option is Exercisable               Which is Exercisable
               -----------------------             -----------------------

                  January 19, 2001                        One-Third
                  February 19, 2001                       One-Third
                  March 19, 2001                          One-Third

        TERM: The option to have a term of ten years, to vest in equal monthly
amounts over the next three months during which time he is providing financial
advice to the Company and shall terminate in accordance with Section 5.8 of the
Plan after the passage of a certain amount of time after Dr. Goldfischer ceases
his relationship with the Company (whether as a consultant, Director or
otherwise).

        EXERCISE: During your lifetime only you can exercise the option. The
Plan also provides for exercise of the option by the personal representative of
your estate or the beneficiary thereof following your death.

        PAYMENT FOR SHARES: The option may be exercised by the delivery of:

        (1) Cash, personal check (unless, at the time of exercise, the Plan
Administrator determines otherwise), bank certified or cashiers check;

        (2) Unless the Plan Administrator in its sole discretion determines
otherwise, shares of the capital stock of the Company held by you for a period
of at least six months having a fair

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market value at the time of exercise, as determined in good faith by the Plan
Administrator, equal to the exercise price; or

        (3) A properly executed exercise notice together with irrevocable
instructions to a broker to promptly deliver to the Company the amount of sale
or loan proceeds to pay the exercise price.

        TERMINATION: If you cease to be a Consultant to the Company for any
reason other than death or termination for cause, and unless by its terms this
option sooner terminates or expires, then you may exercise, for a two-year
period, that portion of your option which is exercisable at the time of such
cessation, but the option shall terminate at the end of such period following
such cessation as to all shares for which it has not theretofore been exercised.

        DEATH OF OPTIONEE: If you die while serving as a Consultant to the
Company or within the two-year period following cessation of such service, this
option may, to the extent that you would have been entitled to exercise this
option, be exercised within one year after your death by the personal
representative of your estate or by the person or persons to whom your rights
under this option shall pass by will or by the applicable laws of descent and
distribution, unless sooner terminated.

        STATUS OF SHAREHOLDER: Neither you nor any person or persons to whom
your rights and privileges under this option may pass shall be, or have any of
the rights or privileges of, a shareholder of the Company with respect to any of
the shares issuable upon the exercise of this option unless and until this
option has been exercised.

        CONTINUATION OF STATUS AS CONSULTANT: Nothing in this Agreement shall
confer upon you any right to continue as a Consultant to the Company, or to
interfere in any way with the right of the Company to terminate your service as
a Consultant to the Company at any time.

        TRANSFER OF OPTION: This option and the rights and privileges conferred
hereby may not be transferred, assigned, pledged or hypothecated in any manner
(whether by operation of law or otherwise) other than by will, by the applicable
laws of descent and distribution, and shall not be subject to execution,
attachment or similar process. Any attempt to transfer, assign, pledge,
hypothecate or otherwise dispose of this option or of any right or privilege
conferred hereby, contrary to law or to the provisions of this Agreement, or the
sale or levy or any attachment or similar process upon the rights and privileges
conferred hereby shall be null and void.

        HOLDING PERIOD: Shares of common stock obtained upon the exercise of
this option may not be sold until six months after the date the option was
granted.

        Your particular attention is directed to the section(s) of the Plan
which describe(s) certain important conditions relating to federal and state
securities laws that must be satisfied before the option can be exercised and
before the company can issue any shares to you. The Company intends to maintain
an effective registration statement with respect to the shares that will be
issued upon exercise of this option but has no obligation to do so. If there is
no effective registration statement, you will not be able to exercise the option
or sell the option shares unless

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exemptions from registration under federal and state securities laws are
available. Such exemptions are very limited and might be unavailable.
Consequently, you might have no opportunity to exercise the option and to
receive shares upon such exercise.

        Please execute the Acceptance and Acknowledgment set forth below and
return it to the undersigned.

NEORX CORPORATION

------------------------------------
PAUL G. ABRAMS
CHIEF EXECUTIVE OFFICER

                          ACCEPTANCE AND ACKNOWLEDGMENT

I, Carl S. Goldfischer, a resident of the State of Wyoming, accept the
nonqualified stock option described above and in NeoRx Corporation's 1994 Stock
Option Plan, and acknowledge receipt of a copy of this Agreement, including a
copy of the Plan. I have read and understand the Plan, including the
provision(s) relating to federal and securities law.

        Dated:
              --------------             ---------------------------------------

--------------------
Taxpayer I.D. Number

By signing below, the spouse of the Optionee, if such Optionee is legally
married as of the date of execution of this Agreement, acknowledges that (s)he
has read this Agreement and the Plan and is familiar with the terms and
provisions thereof, and agrees to be bound by all the terms and conditions of
this Agreement and the Plan.

        Dated:
              --------------             ---------------------------------------

By signing below, the Optionee represents that (s)he is not legally married as
of the date of execution of this Agreement.

        Dated:
              --------------------------------

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