Document:

Confidentiality and Assignment of Proprietary Developments Agreement

 Exhibit 10.46 
 

 
 Christopher C. Gallen, MD, PhD 
 8
Overbrook Parkway 
 Wynnewood, PA 19096 
 Dear Dr. Gallen:

  

	Re:	Confidentiality and Assignment of Proprietary Developments Agreement 

 The purpose of this letter is to describe and record the Agreement between you and Neuromed Technologies Inc. (“Neuromed”) concerning the terms on which you, as an employee of Neuromed Technologies
Inc., will protect and keep confidential certain information received during your employment with Neuromed and pursuant to which you agree to assign certain proprietary developments to Neuromed. 
 In consideration of Neuromed entering into employment with you, and for good and valuable consideration relating thereto, that you acknowledge and agree:

  

	1.	DEFINITIONS: 

 In this Agreement: 
  

	 	(a)	“The Companies” shall mean Neuromed Technologies Inc., Neuromed Pharmaceuticals Inc. and any affiliated companies as defined under the Canada Business
Corporations Act, RSC 1985, C-44, as amended. 

  

	 	(b)	“Confidential Information” means information of the Companies disclosed to you by the Companies, which shall include but not be limited to:

  

	 	(i)	experimental techniques, proprietary assays, screening strategies and technologies, targets for drug discovery and chemical formulae; 

  

	 	(ii)	commercial and financial information concerning the corporate, scientific, and pharmaceutical research activities and plans of the Companies including any information
regarding the Companies’ costs, sales, income, salaries, customers, and all business opportunities or joint ventures considered by the Companies, whether or not pursued; 

	 	(iii)	any and all confidential know-how, trade secrets, and any and all oral, written, electronic or other confidential communications regarding any Proprietary Developments;

  

	 	(c)	“The Companies’ Business” means the specific biomedical research and development activities conducted by the Companies including but not
limited to the discovery and development of novel calcium channel blockers for the purpose of treating diseases; 

  

	 	(d)	“Proprietary Development” means a development or developments including, without limitation; 

  

	 	(i)	enhancements, modifications, additions or other improvements to the intellectual property or assets owned, license, sold, marketed or used by the Companies in
connection with the Companies’ Business; 

  

	 	(ii)	trademarks, copyrights, trade names, business names, logos, design marks and other proprietary marks; 

  

	 	(iii)	inventions, devices, discoveries, concepts, ideas, formulae, know-how, processes, techniques, systems, methods and any improvements, enhancements and modifications thereto, whether
patented or not; 

 developed, created, generated, contributed to or reduced to practice by you alone or jointly with others
pursuant to your activities as an employee, director, officer or consultant of Neuromed and which results from tasks assigned to you by the Companies or which results from the use of the premises or property (including
equipment, supplies or Confidential Information) owned, leased or licensed by the Companies and which reasonably relates to the Neuromed Business. 
  

	2.	CONFIDENTIALITY: 

  

	 	(a)	Basic Obligation Of Confidentiality: 

 You acknowledge and
agree that during your employment with Neuromed, the Companies may disclose to you, or you may otherwise be exposed to, the Companies’ Confidential Information. Neuromed agrees to provide such access to
you and you agree to receive and hold the Confidential Information on the terms and conditions set out herein. Except as set out below, you will keep strictly confidential all Confidential Information and all other information that you acquire, see,
or are informed of, as a direct or indirect consequence of your involvement with the Companies in any capacity or that is revealed to you by the Companies or is generated through negotiations or other activities of third
parties in connection with your involvement, in any capacity, with the Companies’ Business. 
  

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	 	(b)	Fiduciary Relationship: 

 You will be, and act toward
the Companies as a fiduciary and you will not use, duplicate, publish, or disclose at any time, either during or after your involvement in any capacity with the Companies, any of the Confidential Information, whether or
not conceived, originated, discovered, or developed in whole or in part by you. 
  

	 	(c)	Non-Disclosure: 

 Unless Neuromed first gives
you written permission to do so, you will not: 
  

	 	(i)	use or duplicate Confidential Information or recollections thereof; 

  

	 	(ii)	disclose Confidential Information or recollections thereof to any third party; or 

  

	 	(iii)	translate or adapt any Confidential Information or permit any Confidential Information to be used, copied, translated or adapted. 

  

	 	(d)	Taking Precautions: 

 You will take all reasonable
precautions necessary or prudent to prevent material in your possession or control that contains or refers to Confidential Information from being discovered, used, or copied by third parties. 
  

	 	(e)	Neuromed’s Ownership of Confidential Information: 

 As
between you and Neuromed, all right, title and interest in and to the Confidential Information, whether or not created or developed by you, is and shall remain Neuromed’s property. 
  

	 	(f)	Control of Confidential Information and Return of Information: 

 All physical materials produced or prepared by you containing Confidential Information, including designs, formula, memoranda, test results and notes of experiments, drawings, plans, prototypes, samples, accounts, reports, data, financial
statements or proforma estimates and any other materials prepared in the course of your responsibilities or for the benefit of Neuromed shall belong to Neuromed, and you will turn over possession to Neuromed
of all such items in your possession or control promptly when Neuromed requests you to do so. 
  

	 	(g)	Purpose of Use: 

 You will use Confidential Information
only for purposes authorized or directed by Neuromed and its officers and you will not seek access to any Confidential Information that is not relevant to or necessary for those purposes. 
  

	 	(h)	Extent and Duration of Obligation: 

 Except as
Neuromed agrees in writing, your obligations of confidentiality under this Agreement shall continue for the longer of: 
  

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	 	(i)	ten years after the termination of your employment with Neuromed; and 

  

	 	(ii)	with respect to particular items of Confidential Information or material, for so long as those items are not in the public domain, but your obligations will continue if those items
enter the public domain as a consequence of a breach of this Agreement or any other wrongful or negligent act or omission by you. 

 The restrictions in this Agreement regarding confidentiality will not apply to information which is lawfully known by you prior to your employment with Neuromed. 
  

	3.	ASSIGNMENT OF PROPRIETARY DEVELOPMENTS: 

  

	 	(a)	Full Disclosure of Proprietary Developments: 

 You agree to
promptly inform, and make full disclosure of, any Proprietary Development to Neuromed. If required by Neuromed, you will disclose in writing in a log book or such other form or device provided for such purpose by
Neuromed, the details of all Proprietary Developments that you are involved with or responsible for as an employee of Neuromed. 
  

	 	(b)	Assignment of Proprietary Developments to Neuromed: 

 You
will assign, and do hereby irrevocably assign and transfer to Neuromed or to Neuromed’s designee, your entire right, title and interest in and to all Proprietary Developments and any Confidential Information. Without
limiting the foregoing, you agree to waive all moral rights in such Proprietary Developments, and you agree that all Proprietary Developments shall be deemed to be “work made in the course of employment” and that Neuromed
shall be deemed the owner thereof. To the extent that you may own or acquire legal title to any of such Proprietary Developments, you hereby declare and confirm that such legal title is, and will be, held by you only as bare trustee and agent for
Neuromed. You agree that Neuromed will be the exclusive owner of all of your right title and interest in and to each Proprietary Development throughout the world, including all trade secret, patent, copyright, trademark,
industrial design and all other intellectual property rights of any kind and therein. 
  

	 	(c)	Assistance with Proceedings: 

 You further agree at
Neuromed’s request to assist in drafting of any description or specification of the Proprietary Development as may be required for any patent application and to assist with any opposition to, or intervention regarding, an
application for any patent, copyright or trademark or other proceedings relating to any Proprietary Developments. Without limiting the foregoing you agree to execute: 
  

	 	(i)	all instruments that Neuromed may reasonably require to effect, protect, perfect, register, record or patent any Proprietary Developments or the Confidential
Information, or related rights, or Neuromed’s interest therein; and 

  

	 	(ii)	all papers that Neuromed reasonably considers necessary or helpful in obtaining or maintaining such interests and rights during the prosecution of applications thereon
or during the conduct of any interference, litigation, opposition, or any other matter in connection therewith; 

  

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 provided that all expenses incident to such activities will be borne by Neuromed.
Your obligations under this Section will continue beyond termination of your employment with Neuromed, respecting any Proprietary Developments created during your employment with Neuromed, or any Proprietary Developments
perfected or reduced to specific form after termination of your employment with Neuromed, if the conception of the Proprietary Development arose as a result of your work with Neuromed. You agree that
Neuromed’s rights under this Section shall not be limited to this country, Canada, but shall extend to every country of the world. 
  

	 	(d)	Inventions and Improvements: 

 You further agree to treat
all information relating to any Proprietary Development as Confidential Information owned by Neuromed and you will disclose same only to your immediate superior or as he or she may direct. 
  

	 	(e)	Publicity and Publication: 

 Without the prior written
consent of the Chief Scientific Officer of Neuromed you will not make or give any public announcements or press releases or statements to the public or the press regarding any Proprietary Developments, Confidential Information or
concerning The Companies’ Business. You also will not submit an abstract or publication for review or publication until you have prior written approval to do so from the Chief Scientific Officer of Neuromed.

  

	4.	MISCELLANEOUS: 

  

	 	(a)	Governing Law: 

 You agree that this employment agreement
shall be governed for all purposes by the laws of the Province of British Columbia and that any action arising out of this agreement shall be attorn to the jurisdiction of the Supreme Court of British Columbia. 
  

	 	(b)	Equitable Remedies: 

 You acknowledge and agree that a
breach by you of any of your obligations under this Agreement will result in damages to Neuromed that can not be adequately compensated for by a monetary award. Accordingly, in case of any such breach by you, in addition to all other remedies
available to Neuromed at law or in equity, Neuromed shall be entitled as a matter of right to apply to a Court of competent jurisdiction for relief by way of restraining order or injunction, as may be appropriate to ensure compliance with the
provisions of this Agreement. 
  

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	 	(c)	Amendments: 

 No amendment, modification, supplement or
other purported alteration of this Agreement shall be binding unless it is in writing and signed by you and by Neuromed. 
  

	 	(d)	Binding Nature of Agreement: 

 You agree that this
Agreement is binding on your personal representatives. You also agree that the covenants and provisions contained in this Agreement shall survive and continue to bind you following the termination of your employment with Neuromed
regardless of whether Neuromed does, or does not, have just cause for such termination. 
  

	 	(e)	Independent Legal Advice: 

 As this is an important
agreement for you and for Neuromed containing significant undertakings by you, Neuromed suggests you seek independent legal advice regarding this Agreement. 
  

	 	(f)	Severability: 

 If any part or Section of this Agreement is
determined by a Court of competent jurisdiction to be void or unenforceable in whole or in part, then such void or unenforceable part or Section shall be severed, and shall not affect or impair the enforceability or validity of the balance of the
Section or any other part of this Agreement. 
  

	 	(g)	No Waiver: 

 No waiver, delay, indulgence, or failure to
act by Neuromed regarding any particular default or omission by you shall affect or impair any of Neuromed’s rights or remedies regarding that or any subsequent default or omission that is not expressly waived in
writing. 
  

	 	(h)	No Other Obligations: 

 You represent, except as you have
disclosed to Neuromed in writing on the date hereof, that you have no agreements with or obligations to others with respect to the matters covered by this Agreement or concerning the Confidential Information that are in conflict with
anything in this Agreement. 
  

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	5.	ACCEPTANCE: 

 If the foregoing terms and conditions are
acceptable to you, please indicate your acceptance of and agreement to the terms and conditions of this Agreement by signing below on this letter and on the enclosed copy of this letter in the space provided and by returning the enclosed copy so
executed to Neuromed. Your execution and delivery to Neuromed of the enclosed copy of this letter will create a binding agreement between you and Neuromed. 
 Thank you for your co-operation in this matter. 
  

			
	Sincerely,
	
	NEUROMED TECHNOLOGIES INC.
		
	Per:	 	/s/ Bruce S. Colwill, CA
		 	 Bruce S. Colwill, CA
 VP, Finance & Chief
Financial Officer

 ACCEPTED AND AGREED TO THIS 11th DAY OF APRIL, 2005. YOU HAVE READ AND UNDERSTAND THE TERMS AND CONDITIONS SET
OUT IN THIS AGREEMENT. 
  

	
	/s/ Christopher C. Gallen, MD, PhD
	Christopher C. Gallen, MD, PhD

  

 Page 7Employment Agreement, C. Eugene Wright

 Exhibit 10.47 
 

 
  

			
	 October 5, 2007
	  	Christopher C. Gallen, MD, PhD
		  	TELEPHONE: 484.533.6900
		  	Email: cgallen@neuromed.com

 C. Eugene Wright, III 
 16 Carhart Court 
 Pittstown, New Jersey 08867 
 EMPLOYMENT AGREEMENT 
 THIS EMPLOYMENT AGREEMENT (this “Agreement”) effective as of 5th day of October, 2007, is
entered into by and between Neuromed Pharmaceuticals Inc., a Delaware corporation (together with its subsidiaries, the “Company” or “Neuromed”), and C. Eugene Wright, III, an individual residing at 16 Carhart Court,
Pittstown, New Jersey, 08867 (the “Employee”). 
 W I T N E S S E T H: 
 WHEREAS, the Employee desires to serve the Company on a full-time basis as its Vice President Project Leadership; and 
 WHEREAS, the Company desires to employ Employee as its Vice President Project Leadership; 
 NOW THEREFORE in consideration of the mutual benefits to be derived from this Agreement, the Company and the Employee hereby agree as follows:

  

	1.	Term of Employment; Duties; Necessary Agreements. 

 (a)
Commencing on October 29, 2007 (the “Employment Date”), and subject to termination in accordance with the provisions of paragraph 4 hereof, the Company shall employ the Employee with the title of Vice President Project Leadership,
with the duties and responsibilities prescribed for such office in his job description, as well as such additional duties and responsibilities consistent with such position as may from time to time be assigned to the Employee by the
President & CEO, or his delegee. 
 As Vice President Project Leadership, Employee will be responsible for overseeing the entire
project planning process for all functions of Discovery, Clinical, Commercial and Corporate. Provide strategic project planning from Discovery and Preclinical through all Clinical phases, and for Finance and Commercial activities by: monitoring
costs and resources, tracking and determining timelines, decision and risk analysis, in order to meet corporate objectives. Provides direct input into corporate strategic planning, development management processes, critical path issues/solutions,
resource management, and project management from conception through development cycle. Responsible for managing cross-functional project teams and reporting project status to CEO and executive management. Collaborates with project managers and
functional heads to assure integration of project, company, and functional goals towards achieving project milestones and timetables. Identifies issues that may delay product or project 

 C. Eugene Wright, III 
 Oct. 5, 2007 
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and recommends appropriate action to be taken. In addition, Employee will have other responsibilities as directed by the President & CEO. Specific
responsibilities may change as the organization’s needs develop. 
 Employee agrees to perform all his duties and discharge such
responsibilities in a competent, professional and ethical manner, and in accordance with the terms of this Agreement. 
 (b) The Employee
shall devote substantially all of his working time to the business and affairs of the Company other than during vacations and periods of illness or incapacity; provided, however, that nothing in this Agreement shall preclude the Employee from
devoting time required: (i) delivering lectures or fulfilling speaking engagements which have been approved in advance by the President & CEO; or (ii) engaging in charitable and community activities approved in advance by the
President & CEO and provided that Neuromed continues to determine that Employee’s participation in such activities does not interfere with the performance of his duties hereunder. All compensation received by the Employee as a result
of participation in such activities shall be disclosed by the Employee to the Company. 
 (c) As a material condition of his employment,
Employee shall execute on the same date as this Employment Agreement, and be bound by all terms and conditions set forth in, Neuromed’s Non-Competition and Non-Solicitation Agreement (attached hereto and made a part hereof as Attachment A), and
Neuromed’s Confidentiality and Assignment of Proprietary Developments Agreement (attached hereto and made a part hereof as Attachment B). 
  

	2.	Compensation and Benefits. 

 For all services rendered by
the Employee in any capacity during the period of Employee’s employment by the Company, including without limitation, services as an executive officer or member of any committee of the Board of Directors or any subsidiary, affiliate or division
thereof, from and after the Effective Date, the Employee shall be compensated as follows: 
 (a) Base Salary. The Company shall pay the
Employee a base salary (“Base Salary”) at a rate of Two Hundred and Sixty Three Thousand Dollars ($263,000) per year. The individual to whom the Employee shall report may periodically review the Employee’s Base Salary and may
determine to increase the Employee’s salary, in accordance with such policies as the Company may hereafter adopt from time to time, if it deems appropriate. Base Salary will be payable in accordance with the customary payroll practices of the
Company. 
 (b) Incentive Compensation. Beginning in calendar year 2007, Employee will be eligible to receive an annual performance bonus (the
“Performance Bonus”). The final determination on whether or not a Performance Bonus is paid, or the amount of any Performance Bonus, will be made by the CEO and the Board of Directors in their sole discretion. The Employee is eligible for
a Performance Bonus of up to Forty percent (40 %) of his earned Base Salary, in order to be eligible for any Performance Bonus in any given year, Employee must be on the active payroll of Company on the final workday of that calendar year on the
date that such Performance Bonus is or would have been paid out. Performance Bonus may be paid in the form of cash and Profit Sharing contributions. 
 (c) Signing Bonus. Employee will receive a Fifty Thousand Dollar (US$50,000) signing bonus ninety (90 days) after joining Company. This signing bonus must be returned to Company if Employee decides to leave the Company before the one year
anniversary of the Employment Date. 
 (d) Fringe Benefits. Option Grants and Miscellaneous Employment Matters. 
 (i) The Employee shall be entitled to participate in such disability, health and life insurance and other fringe benefit plans or programs of the Company
established from 

 C. Eugene Wright, III 
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time to time by the Board of Directors, if any, to the extent that his position, tenure, salary, age, health and other qualifications make him eligible to
participate, subject to the rules and regulations applicable thereto, and to the same extent as other employees of the Company. In addition, the Employee shall be entitled to the following benefits: 
 (ii) Subject to the approval of the Board of Directors, the Employee will be granted a stock option (the “Employment
Option”) to purchase an undetermined number of shares of the Company’s Common Stock, based on fair market value as may be established by the Board of Directors in its reasonable discretion and as of the Employment Date. The term of the
Employment Option will be for a period of five years from the date of grant. The shares eligible for purchase under the Employment Option grant vest in the following manner: (a) 25% of the total shares on the one-year anniversary of the issue
date; (b) and 1/36th of the remaining shares shall vest on a monthly basis over
the following 36 months. 
 As a condition precedent to Employee’s receipt of, and vesting in, any of the above-referenced Option Grants,
Employee must be on the active payroll of Company on the date that such Option Grants did or would have vested. 
 (e) Withholding and
Employment Tax. Payment of all compensation hereunder shall be subject to customary withholding tax and other employment taxes as may be required with respect to compensation paid by an employer/corporation to an employee. 
 (f) Travel and Expenses. The Company shall pay or reimburse reasonable expenses incurred by the Employee in connection with the performance of his duties
under this Agreement, as may be required and approved by the individual to whom Employee reports. All expenses shall be submitted in writing within thirty (30) days after they are incurred, be consistent with duly approved Company budgets, and
shall be in accordance with such policies and procedures for documentation as the Company may from time to time establish and as the Company determines is required to preserve any deductions for federal income taxation purposes to which the Company
may be entitled. 
 (g) Vacation. Employee shall receive four (4) weeks of vacation annually, administered in accordance with the
Company’s existing vacation policy. 
 (h) No other amounts. The Employee acknowledges and agrees that unless otherwise expressly agreed
in writing between the Employee and the Company, the Employee shall not be entitled, by reason of employment with the Company, to any remuneration, compensation or benefits other than those expressly provided for in this agreement. 
  

	3.	Other Obligations of Neuromed. 

 (a) Neuromed shall
maintain, perform and provide, at its expense, such support personnel, offices and equipment, supplies, furniture, and fixtures, as it determines are reasonably necessary for the performance of services by Employee. 
 (b) The Company will indemnify the Employee to the fullest extent permitted by the Certificate of Incorporation and Bylaws of the Company, as in effect at
such time or on the date of this Agreement, whichever affords greater protection to the Employee. The Company shall have no obligation to indemnify Employee for liabilities resulting from conduct of the Employee with respect to which a court of
competent jurisdiction has made a final determination that Employee committed gross negligence or willful misconduct, or engaged in an illegal act. 

 C. Eugene Wright, III 
 Oct. 5, 2007 
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	4.	Termination of Employment. 

 Notwithstanding any other
provision of this Agreement, Employee’s employment with the Company may be terminated at any time, by either the Employee or the Company, upon written notice to the other party as follows: 
 (a) By the Company, in the event of the Employee’s death, or for Cause (as hereinafter defined). For purposes of this Agreement, “Cause”
shall mean either: (i) the indictment of, or the bringing of formal charges against, Employee by a governmental authority of competent jurisdiction for charges involving fraud or embezzlement; (ii) the conviction of Employee of a crime
involving an act or acts of dishonesty, fraud or moral turpitude by the Employee; (iii) Employee having willfully caused the Company to fail to abide by either a valid contract or any principle of scientific integrity and ethics;
(iv) Employee having committed acts or omissions constituting gross negligence or willful misconduct with respect to the Company; (v) Employee having committed acts or omissions constituting a material breach of Employee’s obligations
under this Agreement or of Employee’s duty of loyalty or fiduciary duty to the Company or any material act of dishonesty or fraud with respect to the Company; or (vi) Employee having committed acts or omissions constituting a material
breach of this Agreement. The Company shall by written notice to the Employee specify the for Cause event relied upon for termination pursuant to this Section 4(a), and Employee’s employment hereunder shall be deemed terminated as of date
specified in the notice. In the event of any termination under this Subsection 4(a), the Company shall pay all amounts then due to the Employee under Section 2(a) of this Agreement for any portion of the payroll period worked but for which
payment had not yet been made up to the date of termination, and if such termination was for Cause, the Company shall have no further obligations to Employee under this Agreement, and any and all options granted hereunder shall terminate according
to their terms, whether vested or not. In the event of the Employee’s death, this agreement shall be deemed terminated as of the date of the Employee’s death. 
 (b) By the Company, in the absence of Cause, for any reason and in its sole and absolute discretion, provided that in such event the Company shall, as liquidated damages or severance pay, or both, continue to pay to
Employee the Base Salary (at a monthly rate equal to the rate in effect immediately prior to such termination) for twelve (12) months from the date of termination (the “Termination Payments”), when, as and if such payments would have
been made in the absence of Employee’s termination. Employee understands and agrees that the Company’s obligation to make any Termination Payments is expressly conditioned upon Employee’s execution of a general release agreement, in a
form reasonably prescribed by the Company. 
 (c) By the Employee, with or without reason, and upon sixty (60) days advance written
notice to Company. 
 (d) By Company, in the event of Employee’s disability. For purposes of this Agreement, “Disability” shall
mean the inability of Employee, in the reasonable judgment of a physician appointed by the Company, to perform his duties of employment for the Company or any of its subsidiaries because of any physical or mental disability or incapacity, where such
disability shall exist for an aggregate period of more than 180 days in any 365-day period, or for any period of 90 consecutive days. Such termination by Neuromed for disability will be coordinated with the disability insurance benefit provided to
Employee under the Company benefits plans. 
  

	5.	Survival of Obligations. 

 Employee’s obligations
under Neuromed’s Non-Competition and Non-Solicitation Agreement (Attachment A), and Neuromed’s Confidentiality and Assignment of Proprietary Developments Agreement (Attachment B) shall survive the termination for any reason of this
Agreement 

 C. Eugene Wright, III 
 Oct. 5, 2007 
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(whether such termination is by the Company, by the Employee, upon a change of control of the Company, upon the expiration of this Agreement or otherwise).

  

	6.	Employee’s Representations. 

 The Employee hereby
represents and warrants to the Company that (i) the execution, delivery and performance of this Agreement by the Employee do not and shall not conflict with, breach, violate or cause a default under any contract, agreement, instrument, order,
judgment or decree to which the Employee is a party or by which he is bound, (ii) the Employee is not a party to or bound by any employment agreement, non-compete agreement or confidentiality agreement with any other person or entity and
(iii) upon the execution and delivery of this Agreement by the Company, this Agreement shall be the valid and binding obligation of the Employee, enforceable in accordance with its terms. The Employee hereby acknowledges and represents that he
has had the opportunity to consult with legal counsel regarding his rights and obligations under this Agreement and that he fully understands the terms and conditions contained herein. 
  

	7.	Enforcement. 

 Because the Employee’s services are
unique and because the Employee has access to confidential information concerning the Company, the parties hereto agree that money damages would not be an adequate remedy for any breach of this Agreement. Therefore, in the event of a breach or
threatened breach of this Agreement, the Company may, in addition to other rights and remedies existing in its favor, apply to any court of competent jurisdiction in the Commonwealth of Pennsylvania for specific performance and/or injunctive or
other relief in order to enforce, or prevent any violations of, the provisions hereof (without posting a bond or other security). 
  

	8.	Severability. 

 In case any one or more of the provisions
or part of a provision contained in this Agreement or any attachment hereto shall for any reason be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability shall be deemed not to affect any other
provision or part of a provision of this Agreement, nor shall such invalidity, illegality or unenforceability affect the validity, legality or enforceability of this Agreement or any provision or provisions hereof in any other jurisdiction; and this
Agreement shall be reformed and construed in such jurisdiction as if such provision or part of a provision held to be invalid or illegal or unenforceable had never been contained herein and such provision or part reformed so that it would be valid,
legal and enforceable to the maximum extent possible. If, in any judicial proceeding, a court shall refuse to enforce any of such separate covenants, then such unenforceable covenants shall be deemed eliminated from the provisions hereof for the
purpose of such proceedings to the extent necessary to permit the remaining separate covenants to be enforced in such proceedings. If, in any judicial proceeding, a court shall refuse to enforce any one or more of such separate covenants because the
total time, scope or area thereof is deemed to be excessive or unreasonable, then it is the intent of the parties hereto that such covenants, which would otherwise be unenforceable due to such excessive or unreasonable period of time, scope or area,
be enforced for such lesser period of time, scope or area as shall be deemed reasonable and not excessive by such court. 
  

	9.	Entire Agreement; Amendment. 

 Except as otherwise set
forth in this Agreement, this Agreement contains the entire agreement between the Company and the Employee with respect to the subject matter hereof and supercedes all prior agreements or understandings by or between the parties. This Agreement may
not be amended, waived, changed, modified or discharged except by an instrument in writing executed by or on behalf of the party against whom enforcement of any amendment, waiver, change, modification or discharge is sought. No course of conduct or
dealing shall be construed to modify, amend or otherwise affect any of the provisions hereof. 

 C. Eugene Wright, III 
 Oct. 5, 2007 
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	10.	General Terms and Condition. 

  

	 	(a)	Independent Legal Advice. 

 As this is an important
agreement for you and for Neuromed containing significant undertakings by you, Neuromed suggests you seek independent legal advice regarding this Agreement. 
  

	 	(b)	No Other Obligations. 

 You represent, except as you have
disclosed to Neuromed in writing on the date hereof, that you have no agreements with or obligations to others with respect to the matters covered by this Agreement. 
  

	11.	Notices. 

 All notices, requests, demands and other
communications hereunder shall be in writing and shall be deemed to have been duly given if physically delivered, delivered by express mail or other expedited service or upon receipt if mailed, postage prepaid, via registered mail, return receipt
requested, addressed as follows: 
  

	 	(a)	To the Company: 

 Bruce Colwill 
 VP Finance & Chief Financial Officer 
 Neuromed Pharmaceuticals 
 301-2389 Health Science Mall 
 Vancouver, BC V6T 1Z4 
 Canada 
 With a copy to: 
 Neuromed Pharmaceuticals
Inc. 
 ATTN: Human Resources Department 
 Six Tower Bridge, Suite 440 
 181 Washington Street 
 Conshohocken, PA 19428 
  

	 	(b)	To the Employee: 

 C. Eugene Wright, III 
 16 Carhart Court 
 Pittstown, New Jersey 08867

 and/or to such other persons and addresses as any party shall have specified in writing to the other. 
  

	12.	Assignability. 

 This Agreement is for personal services to
be performed by Employee and may not be assigned or transferred by Employee, or the obligations of Employee performed by any other party. All of the rights and obligations of the Company under this Agreement are fully assignable and transferable by
the Company. In the event that all or substantially all of the business of the Company is sold or transferred, Employee agrees that this agreement, his Non-Competition and 

 C. Eugene Wright, III 
 Oct. 5, 2007 
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Non-Solicitation Agreement (Attachment A), and Neuromed’s Confidentiality and Assignment of Proprietary Developments Agreement (Attachment B) shall be
assigned to the transferee and shall be binding upon both Employee and transferee. 
  

	13.	Governing Law. 

 This Agreement shall be governed by and
construed under the laws of the Commonwealth of Pennsylvania. 
  

	14.	Waiver and Further Agreement. 

 Any waiver of any breach of
any terms or conditions of this Agreement shall not operate as a waiver of any other breach of such terms or conditions or any other term or condition, nor shall any failure to enforce any provision hereof operate as a waiver of such provision or of
any other provision hereof. Each of the parties hereto agrees to execute all such further instruments and documents and to take all such further action as the other party may reasonably require in order to effectuate the terms and purposes of this
Agreement. 
  

	15.	Headings of No Effect. 

 The paragraph headings contained
in this Agreement are for reference purposes only and shall not in any way affect the meaning or interpretation of this Agreement. 
 IN
WITNESS WHEREOF, the parties hereto have executed this Employment Agreement, and Attachments A and B, attached hereto and made a part hereof, as of the date first above written. 
  

			
	COMPANY:
	
	NEUROMED PHARMACEUTICALS INC.
		
	By:	 	/s/ Christopher C. Gallen
		 	 Christopher C. Gallen
 President &
CEO

	
	EMPLOYEE:
	
	 /s/ C. Eugene Wright, III

	C. Eugene Wright, III

 Attachment A - Non-Competition and Non-Solicitation Agreement 
 Attachment B - Confidentiality and Assignment of Proprietary Developments Agreement

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