Document:

Officers' Certificate

 Exhibit 4.2 
 OFFICERS’ CERTIFICATE 
 OF 

AMGEN INC. 
 Dated as of
November 10, 2011 
 The undersigned officers of the Company certify, pursuant to resolutions duly adopted by the Board of
Directors on October 13, 2011, and the unanimous written consent of the Pricing Committee of the Board of Directors, dated as of November 7, 2011 (collectively, the “Resolutions”), and in accordance with Sections 2.1, 2.2
and 2.3 of the Indenture, dated as of August 4, 2003 (the “Indenture”; capitalized terms used herein and not otherwise defined shall have the meanings given to them in the Indenture), between Amgen Inc., a Delaware corporation
(the “Company”), and The Bank of New York Mellon (as successor to JPMorgan Chase Bank, N.A.), as trustee (the “Trustee”), the following matters related to the issuance of the Company’s 1.875% Senior Notes due
2014 (the “2014 Notes”), 2.50% Senior Notes due 2016 (the “2016 Notes”), 3.875% Senior Notes due 2021 (the “2021 Notes”) and 5.15% Senior Notes due 2041 (the “2041 Notes”):

 1. Attached hereto as Annex A is a true and correct copy of a specimen note (the “Form of 2014 Note”)
representing the 2014 Notes, attached hereto as Annex B is a true and correct copy of a specimen note (the “Form of 2016 Note”) representing the 2016 Notes, attached hereto as Annex C is a true and correct copy of a specimen note
(the “Form of 2021 Note”) representing the 2021 Notes, and attached hereto as Annex D is a true and correct copy of a specimen note (the “Form of 2041 Note”) representing the 2041 Notes. The Form of 2014 Note, Form
of 2016 Note, Form of 2021 Note and Form of 2041 Note are herein collectively referred to as the “Forms of Notes.” The Forms of Notes set forth certain of the terms required to be set forth in this Certificate pursuant to
Section 2.2 of the Indenture, and said terms are incorporated herein by reference. The 2014 Notes, the 2016 Notes, the 2021 Notes and the 2041 Notes are each a separate series of Securities under the Indenture and are referred to herein
collectively as the “Notes.” 
 2. The title of the 2014 Notes shall be the “1.875% Senior Notes due
2014,” the title of the 2016 Notes shall be the “2.50% Senior Notes due 2016,” the title of the 2021 Notes shall be the “3.875% Senior Notes due 2021” and the title of the 2041 Notes shall be the “5.15% Senior Notes due
2041.” 
 3. The 2014 Notes shall be issued at the initial offering price of 99.979% of the principal amount, the 2016
Notes shall be issued at the initial offering price of 99.897% of the principal amount, the 2021 Notes shall be issued at the initial offering price of 99.720% of the principal amount and the 2041 Notes shall be issued at the initial offering price
of 99.168% of the principal amount. 

 4. The Company will initially issue $1,000,000,000 aggregate principal amount of 2014 Notes,
$1,000,000,000 aggregate principal amount of 2016 Notes, $1,750,000,000 aggregate principal amount of 2021 Notes and $2,250,000,000 aggregate principal amount of 2041 Notes (in each case except for Notes authenticated and delivered upon registration
of transfer of, in exchange for, or in lieu of, other Notes pursuant to Sections 2.7, 2.8, 2.11, 3.6 or 9.6 of the Indenture). The Company may issue additional 2014 Notes, 2016 Notes, 2021 Notes and/or 2041 Notes from time to time after the date
hereof, and such Notes will be treated as part of the respective series of Notes for all purposes under the Indenture. 
 5. The
Notes shall be issued as Global Securities only and will be exchangeable for certificated notes (“Certificated Notes”) only if: 
  

	 	(a)	DTC (x) notifies the Company that it is unwilling or unable to continue as depository for the Global Securities or (y) at any time has ceased to be a clearing
agency registered under the Exchange Act at a time when it is required to be registered and, in either case, the Company fails to appoint a successor depository registered as a clearing agency under the Exchange Act within 90 days of notification to
the Company or the Company becoming aware of DTC’s ceasing to be so registered, as the case may be; 

  

	 	(b)	the Company, at its option, notifies the Trustee in writing to the effect that the Company elects to cause the issuance of the Certificated Notes; or

  

	 	(c)	there has occurred and is continuing an Event of Default with respect to the Notes. 

Certificated Notes delivered in exchange for any Global Security or beneficial interests in Global Securities will be registered in the
names, and issued in any approved denominations, requested by or on behalf of the depository (in accordance with its customary procedures). 
 6. The Notes shall be denominated in Dollars and payments of principal and interest shall be made in Dollars. 
 7. In addition to the provisions set forth in Article IV of the Indenture, the following additional provisions shall apply to the Notes and shall be incorporated into the Indenture with respect to the
Notes: 
 Section 4.5 Change of Control Offer 

(a) If a Change of Control Triggering Event occurs, unless the Company has exercised its option to redeem the Notes as described in
Section 5 of the Security, the Company will be required to make an offer (the “Change of Control Offer”) to each Holder to repurchase all or any part (equal to $2,000 or an integral multiple of $1,000 in excess thereof) of that
Holder’s Notes on the terms set forth in such Security. In the Change of Control Offer, the Company shall be required to offer payment in cash equal to 101% of the aggregate principal amount of Notes repurchased, plus accrued and unpaid
interest, if any, on the Notes repurchased to the date of repurchase (the “Change of Control Payment”). Within 30 days following any Change of Control Triggering Event, a notice will be provided to Holders describing the transaction
that constitutes the Change of Control Triggering Event and offering to repurchase the Notes on the date specified in the notice, which date will be no earlier than 30 days and no later than 60 days from the date such notice is provided (the
“Change of Control Payment Date”); provided, however, that in no event will the Change of Control Payment Date occur prior to the date 90 days following the First Issue Date. 

 

  
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 (b) On the Change of Control Payment Date, the Company shall, to the extent lawful:

  

	 	(i)	accept for payment all Notes or portions of Notes properly tendered pursuant to the Change of Control Offer; 

 

	 	(ii)	deposit with the Paying Agent an amount equal to the Change of Control Payment in respect of all Notes or portions of Notes properly tendered; and

  

	 	(iii)	deliver or cause to be delivered to the Trustee the Notes properly accepted together with an Officers’ Certificate stating the aggregate principal amount of Notes
or portions of Notes being repurchased. 

 (c) Notwithstanding the foregoing, the Company shall not repurchase any
Notes if there has occurred and is continuing on the Change of Control Payment Date an Event of Default under the Indenture, other than a Default in the payment of the Change of Control Payment upon a Change of Control Triggering Event. 

(d) The Company will comply with the requirements of Rule 14e-1 under the Exchange Act and any other securities laws and regulations
thereunder to the extent those laws and regulations are applicable in connection with the repurchase of the Notes as a result of a Change of Control Triggering Event. To the extent that the provisions of any such securities laws or regulations
conflict with the Change of Control Offer provisions of the Notes, the Company will comply with those securities laws and regulations and will not be deemed to have breached its obligations under the Change of Control Offer provisions of the Notes
by virtue of any such conflict. 
 (e) For the purposes of this Section 4.5 only, the following definitions shall apply:

 “Beneficial Owner” shall be determined in accordance with Rules 13d-3 and 13d-5 under the Exchange Act or
any successor provisions, except that a Person will be deemed to have beneficial ownership of all shares that Person has the right to acquire irrespective of whether that right is exercisable immediately or only after the passage of time.

  
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 “Change of Control” means the occurrence of any of the following:
(1) the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which is that any Person or Group (other than the Company or one of its Subsidiaries) becomes the Beneficial Owner, directly or
indirectly, of more than 50% of the Company’s Voting Stock or other Voting Stock into which the Company’s Voting Stock is reclassified, consolidated, exchanged or changed, measured by voting power rather than number of shares;
provided, however, that a Person shall not be deemed Beneficial Owner of, or to own beneficially, (A) any securities tendered pursuant to a tender or exchange offer made by or on behalf of such Person or any of such Person’s
affiliates until such tendered securities are accepted for purchase or exchange thereunder, or (B) any securities if such beneficial ownership (i) arises solely as a result of a revocable proxy delivered in response to a proxy or consent
solicitation made pursuant to the applicable rules and regulations under the Exchange Act, and (ii) is not also then reportable on Schedule 13D (or any successor schedule) under the Exchange Act; (2) the direct or indirect sale, transfer,
conveyance or other disposition (other than by way of merger or consolidation), in one or more series of related transactions, of all or substantially all of the Company’s assets and the assets of the Company’s Subsidiaries, taken as a
whole, to one or more Persons or Groups (other than the Company or one of its Subsidiaries); provided that none of the circumstances in this clause (2) will be a Change of Control if the Persons that beneficially own the Company’s
Voting Stock immediately prior to the transaction own, directly or indirectly, shares with a majority of the total voting power of all outstanding voting securities of the surviving or transferee Person that are entitled to vote generally in the
election of that Person’s board of directors, managers or trustees immediately after the transaction; (3) the Company consolidates with, or merges with or into any Person, or any Person consolidates with, or merges with or into, the
Company, in any such event pursuant to a transaction in which any of the Company’s outstanding Voting Stock or the Voting Stock of such other Person is converted into or exchanged for cash, securities or other property, other than such
transaction where the shares of the Company’s Voting Stock outstanding immediately prior to such transaction constitute, or are converted into or exchanged for, a majority of the Voting Stock of the surviving Person or any direct or indirect
parent company of the surviving Person immediately after giving effect to such transaction; (4) the first day on which a majority of the members of the Board of Directors are not Continuing Directors; or (5) the adoption of a plan relating
to the Company’s liquidation or dissolution. Notwithstanding the foregoing, a transaction will not be deemed to involve a Change of Control under clause (1) above if (i) the Company becomes a direct or indirect wholly-owned subsidiary
of a holding company and (ii) (A) the direct or indirect holders of the Voting Stock of such holding company immediately following that transaction are substantially the same as the holders of the Company’s Voting Stock immediately
prior to that transaction or (B) immediately following that transaction no Person (other than a holding company satisfying the requirements of this sentence) is the Beneficial Owner, directly or indirectly, of more than 50% of the Voting Stock
of such holding company. 
 “Change of Control Triggering Event” means the occurrence of both a Change of
Control and a Rating Event. 
 “Fitch” means Fitch, Inc., and its successors. 

“Group” has the meaning given by Section 13(d) and 14(d) of the Exchange Act or any successor provisions and
includes any group acting for the purpose of acquiring, holding or disposing of securities within the meaning of Rule 13d-5(b)(1) under the Exchange Act or any successor provision. 

  
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 “Investment Grade Rating” means a rating equal to or higher than Baa3 (or
the equivalent) by Moody’s, BBB- (or the equivalent) by S&P, and BBB- (or the equivalent) by Fitch, and the equivalent investment grade credit rating from any additional Rating Agency or Rating Agencies selected by the Company. 

“Moody’s” means Moody’s Investors Service, Inc., and its successors. 

“Person” has the meaning given by Section 13(d) and 14(d) of the Exchange Act or any successor provisions.

 “Rating Agencies” means (1) each of Fitch, Moody’s and S&P; and (2) if any of Fitch,
Moody’s or S&P ceases to rate the Notes or fails to make a rating of the Notes publicly available for reasons outside of the Company’s control, a “nationally recognized statistical rating organization” within the meaning of
Rule 15c3-1(c)(2)(vi)(F) under the Exchange Act selected by the Company (as certified by a resolution of the Board of Directors) as a replacement agency for Fitch, Moody’s or S&P, or all of them, as the case may be. 

“Rating Event” means the rating on the applicable series of Notes is lowered by at least two of the three Rating
Agencies and the Notes are rated below an Investment Grade Rating by at least two of the three Rating Agencies on any day during the period commencing 60 days prior to the first public notice of the occurrence of a Change of Control or the
Company’s intention to effect a Change of Control and ending 60 days following consummation of such Change of Control (which period will be extended so long as the rating of the applicable series of Notes is under publicly announced
consideration for a possible downgrade by any of the Rating Agencies). 
 “S&P” means Standard &
Poor’s Rating Services, a division of The McGraw-Hill Companies, Inc., and its successors. 
 “Voting
Stock” as applied to stock of any Person, means shares, interests, participations or other equivalents in the equity interest (however designated) in such Person having ordinary voting power for the election of a majority of the directors
(or the equivalent) of such Person, other than shares, interests, participations or other equivalents having such power only by reason of the occurrence of a contingency. 
 Section 4.6 Limitation on Liens. 
 (a) The Company shall not, nor
shall it permit any of its Subsidiaries to, create or incur any Lien on any of their respective Properties, whether now owned or hereafter acquired, or upon any income or profits therefrom, in order to secure any Indebtedness of the Company, without
effectively providing that such series of Notes shall be equally and ratably secured until such time as such Indebtedness is no longer secured by such Lien, except: 
 (1) Liens existing as of the First Issue Date; 
 (2) Liens granted after the First
Issue Date on any of the Company or any of its Subsidiaries’ Properties securing Indebtedness of the Company created in favor of the Holders of the Notes; 

  
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 (3) Liens securing Indebtedness of the Company which are incurred to extend, renew or
refinance Indebtedness which is secured by Liens permitted to be incurred under the Indenture; provided that those Liens do not extend to or cover any of the Company or any of its Subsidiaries’ Property other than the Property securing
the Indebtedness being refinanced and that the principal amount of such Indebtedness does not exceed the principal amount of the Indebtedness being refinanced; 
 (4) Liens created in substitution of or as replacements for any Liens permitted by the preceding clauses (1) through (3) directly above, provided that, based on a good faith determination
of an Officer of the Company, the Property encumbered under any such substitute or replacement Lien is substantially similar in nature to the Property encumbered by the otherwise permitted Lien which is being replaced; and 

(5) Permitted Liens. 
 (b) Notwithstanding the foregoing, the Company and any of its Subsidiaries may, without securing any series of Notes, create or incur Liens which would otherwise be subject to the restrictions set forth
in the preceding paragraph, if after giving effect thereto, Exempted Debt does not exceed the greater of (x) 35% of Consolidated Net Worth calculated as of the date of the creation or incurrence of the Lien or (y) 35% of Consolidated Net
Worth calculated as of the First Issue Date. 
 Section 4.7 Limitation on Sale and Lease-Back Transactions.

 (a) The Company shall not and shall not permit any of its Subsidiaries to, enter into any sale and lease-back transaction for
the sale and leasing back of any Property, whether now owned or hereafter acquired, of the Company or any Subsidiary of the Company, unless: 
 (1) such transaction was entered into prior to the First Issue Date; 
 (2) such
transaction was for the sale and leasing back of any Property by a Subsidiary of the Company to the Company; 
 (3) such
transaction involves a lease for less than three years; 
 (4) the Company would be entitled to incur Indebtedness secured by a
mortgage on the property to be leased in an amount equal to the Attributable Liens with respect to such sale and lease-back transaction without equally and ratably securing the Notes pursuant to Section 4.6; or 

(5) the Company applies an amount equal to the fair value of the proceeds of the Property sold to the purchase of Property or to the
retirement of long-term Indebtedness of the Company or any of its Subsidiaries within 120 days of the effective date of any such sale and lease-back transaction. In lieu of applying such amount to such retirement, the Company may, or may cause any
of its Subsidiaries to, deliver debt securities to the Trustee therefor for cancellation, such debt securities to be credited at the cost thereof to the Company. 

  
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 (b) Notwithstanding the foregoing, the Company and any of its Subsidiaries may enter into
any sale and lease-back transaction which would otherwise be subject to the foregoing restrictions if after giving effect thereto and at the time of determination, Exempted Debt does not exceed the greater of (a) 35% of Consolidated Net Worth
calculated as of the closing date of the sale-leaseback transaction or (b) 35% of Consolidated Net Worth calculated as of the First Issue Date. 
 8. In addition to the definitions set forth in Article I of the Indenture, each of the Notes shall include the following additional definitions, which, in the event of a conflict with the definition
of terms in the Indenture, shall control: 
 “Attributable Liens” means in connection with a sale and
lease-back transaction the lesser of: 
 (1) the fair market value of the assets subject to such transaction; and 

(2) the present value (discounted at a rate per annum equal to the average interest borne by all outstanding debt securities issued under
the Indenture (which may include debt securities in addition to the Notes) determined on a weighted average basis and compounded semi-annually) of the obligations of the lessee for rental payments during the term of the related lease. 

“Business Day” means any day except a Saturday, Sunday or a legal holiday in the City of New York on which banking
institutions are authorized or required by law, regulation or executive order to close. 
 “Capital Lease”
means any Indebtedness represented by a lease obligation of a Person incurred with respect to real property or equipment acquired or leased by such Person and used in its business that is required to be recorded as a capital lease in accordance with
GAAP. 
 “Consolidated Net Worth” means, as of any date of determination, the Stockholders’ Equity of the
Company and its Consolidated Subsidiaries on that date. 
 “Consolidated Subsidiary” means, as of any date of
determination and with respect to any Person, any Subsidiary of that Person whose financial data is, in accordance with GAAP, reflected in that Person’s consolidated financial statements. 

“Continuing Director” means, as of any date of determination, any member of the Board of Directors who: 

 

	 	(1)	was a member of the Board of Directors on the First Issue Date; or 

  

	 	(2)	was nominated for election or elected to the Board of Directors with the approval of a majority of the Continuing Directors who were members of the Board of Directors
at the time of such nomination or election. 

  
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 “Credit Agreement” means the Credit Agreement, dated as of November 2,
2007, by and among the Company, Citibank N.A., Citicorp USA, Inc., as administrative agent, Barclays Bank PLC, as syndication agent, and Citigroup Global Markets, Inc. and Barclays Capital, as joint lead arrangers and joint book runners, as such
agreement may be amended (including any amendment, restatement, refinancing and successors thereof), supplemented or otherwise modified from time to time, including any increase in the principal amount of the obligations thereunder. 

“Credit Facilities” means, one or more debt facilities (including, without limitation, the Credit Agreement) or
commercial paper facilities, in each case, with banks or other institutional lenders providing for revolving credit loans, term loans, receivables financing (including through the sale of receivables to such lenders or to special purpose entities
formed to borrow from such lenders against such receivables) or letters of credit, in each case, as amended, restated, modified, renewed, refunded, replaced (whether upon or after termination or otherwise) or refinanced (including by means of sales
of debt securities to institutional investors) in whole or in part from time to time. 
 “Exempted Debt” means
the sum of the following as of the date of determination: 
 (1) Indebtedness of the Company incurred after the First Issue Date
and secured by Liens not permitted by Section 4.6(a) above; and 
 (2) Attributable Liens of the Company and any of its
Subsidiaries in respect of sale and lease-back transactions entered into after the First Issue Date pursuant to Section 4.7(b) above. 
 “First Issue Date” means November 10, 2011. 

“GAAP” means accounting principles generally accepted in the United States set forth in the opinions and pronouncements
of the Accounting Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards Board or in such other statements by such other entity as have been approved by a
significant segment of the accounting profession, which are in effect as of the date of determination. 
 “Governmental
Agency” means: 
 (1) any foreign, federal, state, county or municipal government, or political subdivision
thereof; 
 (2) any governmental or quasi-governmental agency, authority, board, bureau, commission, department,
instrumentality or public body; 
 (3) any court or administrative tribunal; and 

(4) with respect to any Person, any arbitration tribunal or other nongovernmental authority to whose jurisdiction that Person has
consented. 
 “Hedging Obligations” means, with respect to any specified Person, the obligations of such Person
under: 

  
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 (1) interest rate swap agreements (whether from fixed to floating or from floating to
fixed), interest rate cap agreements and interest rate collar agreements; 
 (2) other agreements or arrangements designed
to manage interest rates or interest rate risk; and 
 (3) other agreements or arrangements designed to protect such Person
against fluctuations in currency exchange rates or commodity prices. 
 “Indebtedness” of any Person means,
without duplication, any indebtedness, whether or not contingent, in respect of borrowed money or evidenced by bonds, notes, debentures or similar instruments or letters of credit (or reimbursement agreements with respect thereto) or representing
the balance deferred and unpaid of the purchase price of any Property (including pursuant to Capital Leases), except any such balance that constitutes an accrued expense or trade payable, if and to the extent any of the foregoing indebtedness would
appear as a liability upon a balance sheet of such Person prepared on a consolidated basis in accordance with GAAP (but does not include contingent liabilities which appear only in a footnote to a balance sheet), and shall also include, to the
extent not otherwise included, the guaranty of items which would be included within this definition. 
 “Laws”
means, collectively, all foreign, federal, state and local statutes, treaties, rules, regulations, ordinances, codes and administrative or controlling precedents of any Governmental Agency. 

“Lien” means any lien, security interest, charge or encumbrance of any kind (including any conditional sale or other
title retention agreement, any lease in the nature thereof, and any agreement to give any security interest). 

“Make-Whole Amount” means the excess of (1) the net present value, on the redemption date, of the principal being
redeemed or paid and the amount of interest (exclusive of interest accrued to the date of redemption) that would have been payable if such redemption had not been made, over (2) the aggregate principal amount of the 2014 Notes, the 2016 Notes,
the 2021 Notes or the 2041 Notes, as applicable, being redeemed or paid. Net present value shall be determined by discounting, on a semi-annual basis, such principal and interest at the Reinvestment Rate (as determined on the third Business Day
preceding the date such notice of redemption is given) from the respective dates on which such principal and interest would have been payable if such redemption had not been made. 

“Permitted Liens” means: 
 (1) Liens securing Indebtedness under Credit Facilities; 
 (2) Liens on
accounts receivable, merchandise inventory, equipment, and patents, trademarks, trade names and other intangibles, securing Indebtedness of the Company; 

  
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 (3) Liens on any assets of the Company, any of its Subsidiaries’ assets, or the
assets of any joint venture to which the Company or any of its Subsidiaries is a party, created solely to secure obligations incurred to finance the refurbishment, improvement or construction of such asset, which obligations are incurred no later
than 24 months after completion of such refurbishment, improvement or construction, and all renewals, extensions, refinancings, replacements or refundings of such obligations; 
 (4) (a) Liens given to secure the payment of the purchase price incurred in connection with the acquisition (including acquisition through merger or consolidation) of Property (including shares of
stock), including Capital Lease transactions in connection with any such acquisition, and (b) Liens existing on Property at the time of acquisition thereof or at the time of acquisition by the Company or one of its Subsidiaries of any Person
then owning such Property whether or not such existing Liens were given to secure the payment of the purchase price of the Property to which they attach; provided that, with respect to clause (a), the Liens shall be given within 24 months
after such acquisition and shall attach solely to the Property acquired or purchased and any improvements then or thereafter placed thereon; 
 (5) Liens in favor of customs and revenue authorities arising as a matter of law to secure payment of customs duties in connection with the importation of goods; 

(6) Liens upon specific items of inventory or other goods and proceeds of any Person securing such Person’s obligations in
respect of bankers’ acceptances issued or created for the account of such Person to facilitate the purchase, shipment or storage of such inventory or other goods; 
 (7) Liens securing reimbursement obligations with respect to letters of credit that encumber documents and other Property relating to such letters of credit and the products and proceeds thereof;

 (8) Liens on key-man life insurance policies granted to secure Indebtedness of the Company against the cash surrender
value thereof; 
 (9) Liens encumbering customary initial deposits and margin deposits and other Liens in the ordinary
course of business, in each case securing Hedging Obligations and forward contract, option, futures contracts, futures options or similar agreements or arrangements designed to protect the Company or any of its Subsidiaries from fluctuations in
interest rates, currencies or the price of commodities; 
 (10) Liens arising out of conditional sale, title retention,
consignment or similar arrangements for the sale of goods entered into by Company or any of its Subsidiaries in the ordinary course of business; 
 (11) pre-existing Liens on assets acquired by the Company or any of its Subsidiaries after the First Issue Date; 
 (12) Liens in favor of the Company or in favor of any of its Subsidiaries; 

(13) inchoate Liens incident to construction or maintenance of real property, or Liens incident to construction or maintenance of
real property, now or hereafter filed of record for sums not yet delinquent or being contested in good faith, if reserves or other appropriate provisions, if any, as shall be required by GAAP shall have been made therefore; 

  
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 (14) statutory Liens arising in the ordinary course of business with respect to
obligations which are not delinquent or are being contested in good faith, if reserves or other appropriate provisions, if any, as shall be required by GAAP shall have been made therefore; 

(15) Liens consisting of pledges or deposits to secure obligations under workers’ compensation laws or similar legislation,
including Liens of judgments thereunder which are not currently dischargeable; 
 (16) Liens consisting of
pledges or deposits of Property to secure performance in connection with operating leases made in the ordinary course of business to which Company or any of its Subsidiaries is a party as lessee, provided the aggregate value of all such
pledges and deposits in connection with any such lease does not at any time exceed 16 2/3% of the annual fixed rentals payable under such lease; 
 (17) Liens
consisting of deposits of Property to secure statutory obligations of the Company or statutory obligations of any of its Subsidiaries in the ordinary course of its business; 
 (18) Liens consisting of deposits of Property to secure (or in lieu of) surety, appeal or customs bonds in proceedings to which the Company or any of its Subsidiaries is a party in the ordinary
course of its business, but not in excess of $75,000,000; 
 (19) purchase money Liens or purchase money security interests
upon or in any Property acquired or held by Company or any of its Subsidiaries in the ordinary course of business to secure the purchase price of such Property or to secure Indebtedness incurred solely for the purpose of financing the acquisition of
such Property; 
 (20) Liens on an asset created in connection with the acquisition, construction or development of additions,
extensions or improvements to such asset which shall be financed by obligations described in Sections 142, 144(a) or 144(c) of the Internal Revenue Code of 1986, as amended, or by obligations entitled to substantially similar tax benefits under
other legislation or regulations in effect from time to time; and 
 (21) Liens on Property subject to escrow or similar
arrangements established in connection with litigation settlements. 
 “Property” means any property or asset,
whether real, personal or mixed, or tangible or intangible. 
 “Reinvestment Rate” means for the 2014 Notes,
0.25%, for the 2016 Notes, 0.25%, for the 2021 Notes, 0.30%, and for the 2041 Notes, 0.30%, in each case plus the arithmetic mean of the yields under the respective heading “Week Ending” published in the most recent Statistical Release
under the caption “Treasury Constant Maturities” for the maturity (rounded to the nearest month) corresponding to the remaining life to maturity, as of the payment date of the principal being redeemed or paid. If no maturity exactly
corresponds to such maturity, yields for the two published maturities most closely corresponding to such maturity shall be calculated pursuant to the immediately preceding sentence and the Reinvestment Rate shall be interpolated or extrapolated from
such yields on a straight-line basis, rounding in each of such relevant periods to the nearest month. For the purpose of calculating the Reinvestment Rate, the most recent Statistical Release published prior to the date of determination of the
Make-Whole Amount shall be used. 

  
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 “Statistical Release” means the statistical release designated
“H.15(519)” or any successor publication which is published weekly by the Federal Reserve System and which establishes yields on actively traded United States government securities adjusted to constant maturities, or, if such Statistical
Release is not published at the time of any determination under the Indenture, then such other reasonably comparable index which shall be designated by the Company. 
 “Stockholders’ Equity” means, as of any date of determination, stockholders’ equity as of that date determined in accordance with GAAP; provided that there shall be
excluded from Stockholders’ Equity any amount attributable to capital stock that is, directly or indirectly, required to be redeemed or repurchased by the issuer thereof at a specified date or upon the occurrence of specified events or at the
election of the holder thereof. 
 9. The Depository for the Notes shall be The Depository Trust Company
(“DTC”). 
 10. Each of the undersigned is authorized to approve the form, terms and conditions of the Notes.

 11. Each of the undersigned has read the provisions of the Indenture, including the covenants and conditions precedent,
pertaining to the issuance of the Notes. 
 12. In connection with this Certificate, each of the undersigned has examined the
documents, corporate records and certificates and has made such inquiries of the other officers of the Company, which he has deemed necessary to enable him to express an informed opinion as to whether or not such comments and conditions have been
complied with. 
 13. In the opinion of each of the undersigned, all of the conditions and covenants related to the issuance of
the Notes have been complied with. 

  
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 IN WITNESS WHEREOF, the undersigned have executed this Officers’ Certificate as
of the date first set forth above. 
  

					
	By:	 	 /s/    David J. Scott

		 	Name:	 	David J. Scott
		 	Title:	 	Senior Vice President, General Counsel and Secretary

  

					
	By:	 	 /s/    Jonathan M. Peacock

		 	Name:	 	Jonathan M. Peacock
		 	Title:	 	Executive Vice President and
		 		 	Chief Financial Officer

 Signature Page to Officers’ Certificate for the Notes 

 Annex A 
 Form of 2014 Note 

 [Face of Note] 

 
 CUSIP 031162 BJ8 

1.875% Senior Notes due 2014 
  

			
	No.             	 	$            

 AMGEN INC. 
 promises to pay to CEDE & CO. or registered assigns, 
 the principal sum of
             DOLLARS on November 15, 2014. 
 Interest Payment
Dates: May 15 and November 15 
 Record Dates: 15th day prior to May 15 and November 15 
 Dated:              
  

			
	AMGEN INC.
		
	By:	 	  

		 	Name:
		 	Title:
		
	By:	 	  

		 	Name:
		 	Title:

  

			
	 This is one of the Notes referred to
 in the within-mentioned Indenture:

	
	 The Bank of New York Mellon,
   as Trustee

		
	By:	 	  

		 	Authorized Officer

 [REVERSE SIDE OF NOTE] 

1.875% SENIOR NOTES DUE 2014 
 THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF THE DEPOSITORY OR A NOMINEE OF THE DEPOSITORY. THIS SECURITY IS EXCHANGEABLE
FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITORY TO A NOMINEE OF THE DEPOSITORY,
BY A NOMINEE OF THE DEPOSITORY TO THE DEPOSITORY OR ANOTHER NOMINEE OF THE DEPOSITORY OR BY THE DEPOSITORY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITORY OR A NOMINEE OF SUCH A SUCCESSOR DEPOSITORY. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY TO THE ISSUER OR ITS AGENT FOR
REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON
IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 Capitalized terms used herein have the meanings
assigned to them in the Indenture referred to below unless otherwise indicated. 
  

	 	(1)	INTEREST. Amgen Inc., a Delaware corporation (the “Company”), promises to pay interest on the principal amount of this Note at 1.875% per annum
from November 10, 2011 until maturity. The Company will pay interest in cash semi-annually in arrears on May 15 and November 15 of each year, or if any such day is not a Business Day, on the next succeeding Business Day (each, an
“Interest Payment Date”). Interest on the Notes will accrue from the most recent date to which interest has been paid or, if no interest has been paid, from the date of issuance; provided that the first Interest Payment Date
shall be May 15, 2012; provided further that after May 15, 2012, if there is no existing Default in the payment of interest, and if this Note is authenticated between a record date referred to on the face hereof and the next
succeeding Interest Payment Date, interest shall accrue from such next succeeding Interest Payment Date. 

  

	 	(2)	METHOD OF PAYMENT. The Company will pay interest on the Notes (except defaulted interest) to the Persons who are registered Holders of Notes at the close of business on
the day that is 15 days prior to the next succeeding Interest Payment Date (whether or not such day is a Business Day), even if such Notes are canceled after such record date and on or before such Interest Payment Date, except as provided in
Section 2.13 of the Indenture with respect to defaulted interest. The Notes will be payable as to principal and interest at the office or agency of the Company maintained for such purpose in the Borough of Manhattan, the City and State of New
York (or, if the Company fails to maintain such office or agency, at the corporate trust office of the trustee in New York, New York or if the trustee does not maintain an office in New York, at the office of a paying agent in New York), or, at the
option of the Company, payment of interest may be made by check mailed to the Holders at their addresses set forth in the register of Holders; provided that payment by wire transfer of immediately available funds will be required with respect to
principal of and interest on all Global Securities and all other Notes the Holders of which will have provided wire transfer instructions to the Company or the Paying Agent. Such payment will be in the currency of the United States of America.

	 	(3)	PAYING AGENT AND REGISTRAR. Initially, The Bank of New York Mellon (as successor to JPMorgan Chase Bank, N.A.), the Trustee under the Indenture, will act as Paying
Agent and Registrar. The Company may change any Paying Agent or Registrar without notice to any Holder. The Company or any of its Subsidiaries may act in any such capacity. 

 

	 	(4)	INDENTURE. The terms of the Notes include those stated in the Indenture dated August 4, 2003, between the Company and the Trustee (the
“Indenture”), and those made part of the Indenture by the Officers’ Certificate dated November 10, 2011, delivered pursuant thereto (the “Officers’ Certificate”) and the TIA. The Notes are subject to
all such terms, and the Holders are referred to the Indenture and the TIA for a statement of them. 

  

	 	(5)	OPTIONAL REDEMPTION. At any time prior to maturity, the Company will have the option to redeem all or a part of the Notes upon not less than 30 nor more than 60
days’ notice, at a redemption price equal to the sum of (1) 100% of the principal amount of any Notes being redeemed plus accrued and unpaid interest to, but not including, the redemption date, and (2) the Make-Whole Amount. Unless
the Company defaults in the payment of the redemption price, interest will cease to accrue on the Notes or portions thereof called for redemption on the applicable redemption date. 

 

	 	(6)	NOTICE OF REDEMPTION. Notice of redemption will be mailed at least 30 days but not more than 60 days before the redemption date to each Holder whose Notes are to be
redeemed at its registered address, except that redemption notices may be mailed more than 60 days prior to a redemption date if the notice is issued in connection with a defeasance of the Notes or a satisfaction or discharge of the Indenture. Notes
in denominations larger than $2,000 may be redeemed in part but only in whole multiples of $1,000, unless all of the Notes held by a Holder are to be redeemed. 

 

	 	(7)	MANDATORY REDEMPTION. Except as provided in Section 8 below, the Company is not required to make mandatory redemption or sinking fund payments with respect to the
Notes. 

  

	 	(8)	CHANGE OF CONTROL TRIGGERING EVENT. In the event of a Change of Control Triggering Event, the Holders may require the Company to purchase for cash all or a portion of
their Notes at a purchase price equal to 101% of the principal amount of the notes, plus accrued and unpaid interest, if any, pursuant to the provisions of Section 7 of the Officers’ Certificate. 

 

	 	(9)	DEFEASANCE PRIOR TO MATURITY. The Indenture contains provisions for defeasance of (i) the entire indebtedness of the Notes or (ii) certain covenants and
Events of Default with respect to the Notes, in each case upon compliance with certain conditions set forth therein. 

	 	(10)	RESTRICTIVE COVENANTS. The Indenture and the Officers’ Certificate impose certain limitations on the Company and its Subsidiaries, including limitations on the
Company’s and its Subsidiaries’ ability to create or incur certain Liens on any of their respective properties or assets and to enter into certain sale and lease-back transactions and on the Company’s ability to engage in mergers or
consolidations or the conveyance, transfer or lease of all or substantially all of its properties and assets. These limitations are subject to a number of important qualifications and exceptions and reference is made to the Indenture and the
Officers’ Certificate for a description thereof. 

  

	 	(11)	DENOMINATIONS, TRANSFER, EXCHANGE. The Notes are in registered form without coupons in denominations of $2,000 and integral multiples of $1,000. The transfer of Notes
may be registered and Notes may be exchanged as provided in the Indenture. The Registrar and the Trustee may require a Holder, among other things, to furnish appropriate endorsements and transfer documents and the Company may require a Holder to pay
any taxes and fees required by law or permitted by the Indenture. The Company need not exchange or register the transfer of any Note or portion of a Note selected for redemption, except for the unredeemed portion of any Note being redeemed in part.
Also, the Company need not exchange or register the transfer of any Notes for a period of 15 days before a selection of Notes to be redeemed or during the period between a record date and the corresponding Interest Payment Date.

  

	 	(12)	PERSONS DEEMED OWNERS. The registered Holder of a Note may be treated as its owner for all purposes. 

 

	 	(13)	AMENDMENT, SUPPLEMENT AND WAIVER. Subject to certain exceptions, the Indenture or the Notes may be amended or supplemented with the consent of the Holders of at least a
majority in aggregate principal amount of the then outstanding Notes voting as a single class, and any existing Default or Event or Default or compliance with any provision of the Indenture or the Notes may be waived with the consent of the Holders
of a majority in aggregate principal amount of the then outstanding Notes voting as a single class. Without the consent of any Holder of a Note, the Indenture or the Notes may be amended or supplemented to cure any ambiguity, defect or
inconsistency, to comply with Article V of the Indenture, to provide for uncertificated Notes in addition to or in place of certificated Notes, to make any change that would not adversely affect the rights under the Indenture of any such Holder, to
provide for the issuance of any additional notes as permitted by the Indenture, to appoint a successor trustee with respect to the notes and to add to or change any of the provisions of the Indenture necessary to provide for the administration of
the trusts in the Indenture by more than one trustee, or to comply with the requirements of the SEC in order to effect or maintain the qualification of the Indenture under the TIA. No amendment to cure any ambiguity, defect or inconsistency in the
Indenture made solely to conform the Indenture to the description of notes contained in the Prospectus Supplement related to the Notes, dated November 7, 2011, will be deemed to adversely affect the interests of the Holders of the Notes.

  

	 	(14)	DEFAULTS AND REMEDIES. If an Event of Default shall occur and be continuing, the principal of the Notes may be declared (or, in certain cases, shall ipso facto become)
due and payable in the manner and with the effect provided in the Indenture. 

  

	 	(15)	TRUSTEE DEALINGS WITH COMPANY. The Trustee under the Indenture, in its individual or any other capacity, may deal with the Company or an Affiliate of the Company with
the same rights it would have if it were not Trustee. 

	 	(16)	NO RECOURSE AGAINST OTHERS. A director, officer, employee or stockholder of the Company shall not have any liability for any obligations of the Company under the Notes
or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder by accepting a Note waives and releases all such liability. The waiver and release are part of the consideration for the
issuance of the Notes. 

  

	 	(17)	AUTHENTICATION. This Note will not be valid until authenticated by the manual signature of the Trustee or an authenticating agent. 

 

	 	(18)	ABBREVIATIONS. Customary abbreviations may be used in the name of a Holder or an assignee, such as: TEN COM (= tenants in common), TEN ENT (= tenants by the
entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST (= Custodian), and U/G/M/A (= Uniform Gifts to Minors Act). 

 

	 	(19)	CUSIP NUMBERS. Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification Procedures, the Company has caused CUSIP numbers to be
printed on the Notes, and the Trustee may use CUSIP numbers in notices of redemption as a convenience to Holders. No representation is made as to the accuracy of such numbers either as printed on the Notes or as contained in any notice of
redemption, and reliance may be placed only on the other identification numbers placed thereon. 

  

	 	(20)	GOVERNING LAW. THE INTERNAL LAW OF THE STATE OF NEW YORK WILL GOVERN AND BE USED TO CONSTRUE THE INDENTURE AND THIS NOTE WITHOUT GIVING EFFECT TO APPLICABLE PRINCIPLES
OF CONFLICTS OF LAW TO THE EXTENT THAT THE APPLICATION OF THE LAWS OF ANOTHER JURISDICTION WOULD BE REQUIRED THEREBY. 

 The Company will furnish to any Holder upon written request and without charge a copy of the Indenture and/or the Officers’ Certificate. 

Requests may be made to: 
 Amgen Inc. 
 One Amgen Center Drive 

Thousand Oaks, CA 91320-1799 
 Attention: Investor Relations 

 ASSIGNMENT FORM 

To assign this Note, fill in the form below: 
  

	
	(I) or (we) assign and transfer this Note to:
                                         
                   
	         (Insert assignee’s legal name)

	  

	(Insert assignee’s soc. sec. or tax I.D. no.)
	  

 
  

 

	 (Print or type assignee’s name, address and zip code)

 
 and irrevocably appoint
                                         
                                         
                                         
                                         
    
 to transfer this Note on the books of the Company. The agent may substitute another to act for him.

 

	
	Date:                     
	
	Your Signature:
                                         
                                         
                  
	(Sign exactly as your name appears on the face of this Note)
	
	  
 Signature Guarantee*:
                                         
           

	
	 *  Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to the
Trustee).

 Annex B 
 Form of 2016 Note 
  

 [Face of Note] 

 
 CUSIP 031162 BL3 

2.50% Senior Notes due 2016 
  

			
	No.             	 	$            

 AMGEN INC. 
 promises to pay to CEDE & CO. or registered assigns, 
 the principal sum of
             DOLLARS on November 15, 2016. 
 Interest Payment
Dates: May 15 and November 15 
 Record Dates: 15th day prior to May 15 and November 15 
 Dated:              
  

			
	AMGEN INC.
		
	By:	 	  

		 	Name:
		 	Title:
		
	By:	 	  

		 	Name:
		 	Title:

  

			
	 This is one of the Notes referred to
 in the within-mentioned Indenture:

	
	 The Bank of New York Mellon,

  as Trustee

		
	By:	 	  

		 	Authorized Officer

 [REVERSE SIDE OF NOTE] 

2.50% SENIOR NOTES DUE 2016 
 THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF THE DEPOSITORY OR A NOMINEE OF THE DEPOSITORY. THIS SECURITY IS EXCHANGEABLE
FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITORY TO A NOMINEE OF THE DEPOSITORY,
BY A NOMINEE OF THE DEPOSITORY TO THE DEPOSITORY OR ANOTHER NOMINEE OF THE DEPOSITORY OR BY THE DEPOSITORY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITORY OR A NOMINEE OF SUCH A SUCCESSOR DEPOSITORY. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY TO THE ISSUER OR ITS AGENT FOR
REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON
IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 Capitalized terms used herein have the meanings
assigned to them in the Indenture referred to below unless otherwise indicated. 
  

	 	(1)	INTEREST. Amgen Inc., a Delaware corporation (the “Company”), promises to pay interest on the principal amount of this Note at 2.50% per annum
from November 10, 2011 until maturity. The Company will pay interest in cash semi-annually in arrears on May 15 and November 15 of each year, or if any such day is not a Business Day, on the next succeeding Business Day (each, an
“Interest Payment Date”). Interest on the Notes will accrue from the most recent date to which interest has been paid or, if no interest has been paid, from the date of issuance; provided that the first Interest Payment Date
shall be May 15, 2012; provided further that after May 15, 2012, if there is no existing Default in the payment of interest, and if this Note is authenticated between a record date referred to on the face hereof and the next
succeeding Interest Payment Date, interest shall accrue from such next succeeding Interest Payment Date. 

  

	 	(2)	METHOD OF PAYMENT. The Company will pay interest on the Notes (except defaulted interest) to the Persons who are registered Holders of Notes at the close of business on
the day that is 15 days prior to the next succeeding Interest Payment Date (whether or not such day is a Business Day), even if such Notes are canceled after such record date and on or before such Interest Payment Date, except as provided in
Section 2.13 of the Indenture with respect to defaulted interest. The Notes will be payable as to principal and interest at the office or agency of the Company maintained for such purpose in the Borough of Manhattan, the City and State of New
York (or, if the Company fails to maintain such office or agency, at the corporate trust office of the trustee in New York, New York or if the trustee does not maintain an office in New York, at the office of a paying agent in New York), or, at the
option of the Company, payment of interest may be made by check mailed to the Holders at their addresses set forth in the register of Holders; provided that payment by wire transfer of immediately available funds will be required with respect to
principal of and interest on all Global Securities and all other Notes the Holders of which will have provided wire transfer instructions to the Company or the Paying Agent. Such payment will be in the currency of the United States of America.

	 	(3)	PAYING AGENT AND REGISTRAR. Initially, The Bank of New York Mellon (as successor to JPMorgan Chase Bank, N.A.), the Trustee under the Indenture, will act as Paying
Agent and Registrar. The Company may change any Paying Agent or Registrar without notice to any Holder. The Company or any of its Subsidiaries may act in any such capacity. 

 

	 	(4)	INDENTURE. The terms of the Notes include those stated in the Indenture dated August 4, 2003, between the Company and the Trustee (the
“Indenture”), and those made part of the Indenture by the Officers’ Certificate dated November 10, 2011, delivered pursuant thereto (the “Officers’ Certificate”) and the TIA. The Notes are subject to
all such terms, and the Holders are referred to the Indenture and the TIA for a statement of them. 

  

	 	(5)	OPTIONAL REDEMPTION. At any time prior to maturity, the Company will have the option to redeem all or a part of the Notes upon not less than 30 nor more than 60
days’ notice, at a redemption price equal to the sum of (1) 100% of the principal amount of any Notes being redeemed plus accrued and unpaid interest to, but not including, the redemption date, and (2) the Make-Whole Amount. Unless
the Company defaults in the payment of the redemption price, interest will cease to accrue on the Notes or portions thereof called for redemption on the applicable redemption date. 

 

	 	(6)	NOTICE OF REDEMPTION. Notice of redemption will be mailed at least 30 days but not more than 60 days before the redemption date to each Holder whose Notes are to be
redeemed at its registered address, except that redemption notices may be mailed more than 60 days prior to a redemption date if the notice is issued in connection with a defeasance of the Notes or a satisfaction or discharge of the Indenture. Notes
in denominations larger than $2,000 may be redeemed in part but only in whole multiples of $1,000, unless all of the Notes held by a Holder are to be redeemed. 

 

	 	(7)	MANDATORY REDEMPTION. Except as provided in Section 8 below, the Company is not required to make mandatory redemption or sinking fund payments with respect to the
Notes. 

  

	 	(8)	CHANGE OF CONTROL TRIGGERING EVENT. In the event of a Change of Control Triggering Event, the Holders may require the Company to purchase for cash all or a portion of
their Notes at a purchase price equal to 101% of the principal amount of the notes, plus accrued and unpaid interest, if any, pursuant to the provisions of Section 7 of the Officers’ Certificate. 

 

	 	(9)	DEFEASANCE PRIOR TO MATURITY. The Indenture contains provisions for defeasance of (i) the entire indebtedness of the Notes or (ii) certain covenants and
Events of Default with respect to the Notes, in each case upon compliance with certain conditions set forth therein. 

	 	(10)	RESTRICTIVE COVENANTS. The Indenture and the Officers’ Certificate impose certain limitations on the Company and its Subsidiaries, including limitations on the
Company’s and its Subsidiaries’ ability to create or incur certain Liens on any of their respective properties or assets and to enter into certain sale and lease-back transactions and on the Company’s ability to engage in mergers or
consolidations or the conveyance, transfer or lease of all or substantially all of its properties and assets. These limitations are subject to a number of important qualifications and exceptions and reference is made to the Indenture and the
Officers’ Certificate for a description thereof. 

  

	 	(11)	DENOMINATIONS, TRANSFER, EXCHANGE. The Notes are in registered form without coupons in denominations of $2,000 and integral multiples of $1,000. The transfer of Notes
may be registered and Notes may be exchanged as provided in the Indenture. The Registrar and the Trustee may require a Holder, among other things, to furnish appropriate endorsements and transfer documents and the Company may require a Holder to pay
any taxes and fees required by law or permitted by the Indenture. The Company need not exchange or register the transfer of any Note or portion of a Note selected for redemption, except for the unredeemed portion of any Note being redeemed in part.
Also, the Company need not exchange or register the transfer of any Notes for a period of 15 days before a selection of Notes to be redeemed or during the period between a record date and the corresponding Interest Payment Date.

  

	 	(12)	PERSONS DEEMED OWNERS. The registered Holder of a Note may be treated as its owner for all purposes. 

 

	 	(13)	AMENDMENT, SUPPLEMENT AND WAIVER. Subject to certain exceptions, the Indenture or the Notes may be amended or supplemented with the consent of the Holders of at least a
majority in aggregate principal amount of the then outstanding Notes voting as a single class, and any existing Default or Event or Default or compliance with any provision of the Indenture or the Notes may be waived with the consent of the Holders
of a majority in aggregate principal amount of the then outstanding Notes voting as a single class. Without the consent of any Holder of a Note, the Indenture or the Notes may be amended or supplemented to cure any ambiguity, defect or
inconsistency, to comply with Article V of the Indenture, to provide for uncertificated Notes in addition to or in place of certificated Notes, to make any change that would not adversely affect the rights under the Indenture of any such Holder, to
provide for the issuance of any additional notes as permitted by the Indenture, to appoint a successor trustee with respect to the notes and to add to or change any of the provisions of the Indenture necessary to provide for the administration of
the trusts in the Indenture by more than one trustee, or to comply with the requirements of the SEC in order to effect or maintain the qualification of the Indenture under the TIA. No amendment to cure any ambiguity, defect or inconsistency in the
Indenture made solely to conform the Indenture to the description of notes contained in the Prospectus Supplement related to the Notes, dated November 7, 2011, will be deemed to adversely affect the interests of the Holders of the Notes.

  

	 	(14)	DEFAULTS AND REMEDIES. If an Event of Default shall occur and be continuing, the principal of the Notes may be declared (or, in certain cases, shall ipso facto become)
due and payable in the manner and with the effect provided in the Indenture. 

  

	 	(15)	TRUSTEE DEALINGS WITH COMPANY. The Trustee under the Indenture, in its individual or any other capacity, may deal with the Company or an Affiliate of the Company with
the same rights it would have if it were not Trustee. 

	 	(16)	NO RECOURSE AGAINST OTHERS. A director, officer, employee or stockholder of the Company shall not have any liability for any obligations of the Company under the Notes
or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder by accepting a Note waives and releases all such liability. The waiver and release are part of the consideration for the
issuance of the Notes. 

  

	 	(17)	AUTHENTICATION. This Note will not be valid until authenticated by the manual signature of the Trustee or an authenticating agent. 

 

	 	(18)	ABBREVIATIONS. Customary abbreviations may be used in the name of a Holder or an assignee, such as: TEN COM (= tenants in common), TEN ENT (= tenants by the
entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST (= Custodian), and U/G/M/A (= Uniform Gifts to Minors Act). 

 

	 	(19)	CUSIP NUMBERS. Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification Procedures, the Company has caused CUSIP numbers to be
printed on the Notes, and the Trustee may use CUSIP numbers in notices of redemption as a convenience to Holders. No representation is made as to the accuracy of such numbers either as printed on the Notes or as contained in any notice of
redemption, and reliance may be placed only on the other identification numbers placed thereon. 

  

	 	(20)	GOVERNING LAW. THE INTERNAL LAW OF THE STATE OF NEW YORK WILL GOVERN AND BE USED TO CONSTRUE THE INDENTURE AND THIS NOTE WITHOUT GIVING EFFECT TO APPLICABLE PRINCIPLES
OF CONFLICTS OF LAW TO THE EXTENT THAT THE APPLICATION OF THE LAWS OF ANOTHER JURISDICTION WOULD BE REQUIRED THEREBY. 

 The Company will furnish to any Holder upon written request and without charge a copy of the Indenture and/or the Officers’ Certificate. 

Requests may be made to: 
 Amgen Inc. 
 One Amgen Center Drive 

Thousand Oaks, CA 91320-1799 
 Attention: Investor Relations 

 ASSIGNMENT FORM 

To assign this Note, fill in the form below: 
  

	
	(I) or (we) assign and transfer this Note to:
                                         
                   
	         (Insert assignee’s legal name)

	  

	(Insert assignee’s soc. sec. or tax I.D. no.)
	  

 
  

 

	 (Print or type assignee’s name, address and zip code)

 
 and irrevocably appoint
                                         
                                         
                                         
                                         
    
 to transfer this Note on the books of the Company. The agent may substitute another to act for him.

 

	
	Date:                     
	
	Your Signature:
                                         
                                         
                  
	(Sign exactly as your name appears on the face of this Note)
	
	  
 Signature Guarantee*:
                                         
           

	
	 *  Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to the
Trustee)

 Annex C 
 Form of 2021 Note 

 [Face of Note] 

 
 CUSIP 031162 BM1 

3.875% Senior Notes due 2021 
  

			
	No.             	 	$            

 AMGEN INC. 
 promises to pay to CEDE & CO. or registered assigns, 
 the principal sum of
             DOLLARS on November 15, 2021. 
 Interest Payment
Dates: May 15 and November 15 
 Record Dates: 15th day prior to May 15 and November 15 
 Dated:              
  

			
	AMGEN INC.
		
	By:	 	  

		 	Name:
		 	Title:
		
	By:	 	  

		 	Name:
		 	Title:

  

			
	 This is one of the Notes referred to
 in the within-mentioned Indenture:

	
	 The Bank of New York Mellon,
   as Trustee

		
	By:	 	  

		 	Authorized Officer

 [REVERSE SIDE OF NOTE] 

3.875% SENIOR NOTES DUE 2021 
 THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF THE DEPOSITORY OR A NOMINEE OF THE DEPOSITORY. THIS SECURITY IS EXCHANGEABLE
FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITORY TO A NOMINEE OF THE DEPOSITORY,
BY A NOMINEE OF THE DEPOSITORY TO THE DEPOSITORY OR ANOTHER NOMINEE OF THE DEPOSITORY OR BY THE DEPOSITORY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITORY OR A NOMINEE OF SUCH A SUCCESSOR DEPOSITORY. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY TO THE ISSUER OR ITS AGENT FOR
REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON
IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 Capitalized terms used herein have the meanings
assigned to them in the Indenture referred to below unless otherwise indicated. 
  

	 	(1)	INTEREST. Amgen Inc., a Delaware corporation (the “Company”), promises to pay interest on the principal amount of this Note at 3.875% per annum
from November 10, 2011 until maturity. The Company will pay interest in cash semi-annually in arrears on May 15 and November 15 of each year, or if any such day is not a Business Day, on the next succeeding Business Day (each, an
“Interest Payment Date”). Interest on the Notes will accrue from the most recent date to which interest has been paid or, if no interest has been paid, from the date of issuance; provided that the first Interest Payment Date
shall be May 15, 2012; provided further that after May 15, 2012, if there is no existing Default in the payment of interest, and if this Note is authenticated between a record date referred to on the face hereof and the next
succeeding Interest Payment Date, interest shall accrue from such next succeeding Interest Payment Date. 

  

	 	(2)	METHOD OF PAYMENT. The Company will pay interest on the Notes (except defaulted interest) to the Persons who are registered Holders of Notes at the close of business on
the day that is 15 days prior to the next succeeding Interest Payment Date (whether or not such day is a Business Day), even if such Notes are canceled after such record date and on or before such Interest Payment Date, except as provided in
Section 2.13 of the Indenture with respect to defaulted interest. The Notes will be payable as to principal and interest at the office or agency of the Company maintained for such purpose in the Borough of Manhattan, the City and State of New
York (or, if the Company fails to maintain such office or agency, at the corporate trust office of the trustee in New York, New York or if the trustee does not maintain an office in New York, at the office of a paying agent in New York), or, at the
option of the Company, payment of interest may be made by check mailed to the Holders at their addresses set forth in the register of Holders; provided that payment by wire transfer of immediately available funds will be required with respect to
principal of and interest on all Global Securities and all other Notes the Holders of which will have provided wire transfer instructions to the Company or the Paying Agent. Such payment will be in the currency of the United States of America.

	 	(3)	PAYING AGENT AND REGISTRAR. Initially, The Bank of New York Mellon (as successor to JPMorgan Chase Bank, N.A.), the Trustee under the Indenture, will act as Paying
Agent and Registrar. The Company may change any Paying Agent or Registrar without notice to any Holder. The Company or any of its Subsidiaries may act in any such capacity. 

 

	 	(4)	INDENTURE. The terms of the Notes include those stated in the Indenture dated August 4, 2003, between the Company and the Trustee (the
“Indenture”), and those made part of the Indenture by the Officers’ Certificate dated November 10, 2011, delivered pursuant thereto (the “Officers’ Certificate”) and the TIA. The Notes are subject to
all such terms, and the Holders are referred to the Indenture and the TIA for a statement of them. 

  

	 	(5)	OPTIONAL REDEMPTION. At any time prior to maturity, the Company will have the option to redeem all or a part of the Notes upon not less than 30 nor more than 60
days’ notice. If the Notes are redeemed before August 15, 2021 (three months prior to the maturity date of the Notes) the redemption price will equal the sum of (1) 100% of the principal amount being redeemed, plus accrued and unpaid
interest to, but not including, the redemption date, and (2) the Make-Whole Amount. If the Notes are redeemed on or after August 15, 2021 (three months prior to the maturity date of the Notes), the redemption price will equal 100% of the
principal amount being redeemed, plus accrued and unpaid interest to, but not including, the redemption date. Unless the Company defaults in the payment of the redemption price, interest will cease to accrue on the Notes or portions thereof called
for redemption on the applicable redemption date. 

  

	 	(6)	NOTICE OF REDEMPTION. Notice of redemption will be mailed at least 30 days but not more than 60 days before the redemption date to each Holder whose Notes are to be
redeemed at its registered address, except that redemption notices may be mailed more than 60 days prior to a redemption date if the notice is issued in connection with a defeasance of the Notes or a satisfaction or discharge of the Indenture. Notes
in denominations larger than $2,000 may be redeemed in part but only in whole multiples of $1,000, unless all of the Notes held by a Holder are to be redeemed. 

 

	 	(7)	MANDATORY REDEMPTION. Except as provided in Section 8 below, the Company is not required to make mandatory redemption or sinking fund payments with respect to the
Notes. 

  

	 	(8)	CHANGE OF CONTROL TRIGGERING EVENT. In the event of a Change of Control Triggering Event, the Holders may require the Company to purchase for cash all or a portion of
their Notes at a purchase price equal to 101% of the principal amount of the notes, plus accrued and unpaid interest, if any, pursuant to the provisions of Section 7 of the Officers’ Certificate. 

	 	(9)	DEFEASANCE PRIOR TO MATURITY. The Indenture contains provisions for defeasance of (i) the entire indebtedness of the Notes or (ii) certain covenants and
Events of Default with respect to the Notes, in each case upon compliance with certain conditions set forth therein. 

  

	 	(10)	RESTRICTIVE COVENANTS. The Indenture and the Officers’ Certificate impose certain limitations on the Company and its Subsidiaries, including limitations on the
Company’s and its Subsidiaries’ ability to create or incur certain Liens on any of their respective properties or assets and to enter into certain sale and lease-back transactions and on the Company’s ability to engage in mergers or
consolidations or the conveyance, transfer or lease of all or substantially all of its properties and assets. These limitations are subject to a number of important qualifications and exceptions and reference is made to the Indenture and the
Officers’ Certificate for a description thereof. 

  

	 	(11)	DENOMINATIONS, TRANSFER, EXCHANGE. The Notes are in registered form without coupons in denominations of $2,000 and integral multiples of $1,000. The transfer of Notes
may be registered and Notes may be exchanged as provided in the Indenture. The Registrar and the Trustee may require a Holder, among other things, to furnish appropriate endorsements and transfer documents and the Company may require a Holder to pay
any taxes and fees required by law or permitted by the Indenture. The Company need not exchange or register the transfer of any Note or portion of a Note selected for redemption, except for the unredeemed portion of any Note being redeemed in part.
Also, the Company need not exchange or register the transfer of any Notes for a period of 15 days before a selection of Notes to be redeemed or during the period between a record date and the corresponding Interest Payment Date.

  

	 	(12)	PERSONS DEEMED OWNERS. The registered Holder of a Note may be treated as its owner for all purposes. 

 

	 	(13)	AMENDMENT, SUPPLEMENT AND WAIVER. Subject to certain exceptions, the Indenture or the Notes may be amended or supplemented with the consent of the Holders of at least a
majority in aggregate principal amount of the then outstanding Notes voting as a single class, and any existing Default or Event or Default or compliance with any provision of the Indenture or the Notes may be waived with the consent of the Holders
of a majority in aggregate principal amount of the then outstanding Notes voting as a single class. Without the consent of any Holder of a Note, the Indenture or the Notes may be amended or supplemented to cure any ambiguity, defect or
inconsistency, to comply with Article V of the Indenture, to provide for uncertificated Notes in addition to or in place of certificated Notes, to make any change that would not adversely affect the rights under the Indenture of any such Holder, to
provide for the issuance of any additional notes as permitted by the Indenture, to appoint a successor trustee with respect to the notes and to add to or change any of the provisions of the Indenture necessary to provide for the administration of
the trusts in the Indenture by more than one trustee, or to comply with the requirements of the SEC in order to effect or maintain the qualification of the Indenture under the TIA. No amendment to cure any ambiguity, defect or inconsistency in the
Indenture made solely to conform the Indenture to the description of notes contained in the Prospectus Supplement related to the Notes, dated November 7, 2011, will be deemed to adversely affect the interests of the Holders of the Notes.

	 	(14)	DEFAULTS AND REMEDIES. If an Event of Default shall occur and be continuing, the principal of the Notes may be declared (or, in certain cases, shall ipso facto become)
due and payable in the manner and with the effect provided in the Indenture. 

  

	 	(15)	TRUSTEE DEALINGS WITH COMPANY. The Trustee under the Indenture, in its individual or any other capacity, may deal with the Company or an Affiliate of the Company with
the same rights it would have if it were not Trustee. 

  

	 	(16)	NO RECOURSE AGAINST OTHERS. A director, officer, employee or stockholder of the Company shall not have any liability for any obligations of the Company under the Notes
or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder by accepting a Note waives and releases all such liability. The waiver and release are part of the consideration for the
issuance of the Notes. 

  

	 	(17)	AUTHENTICATION. This Note will not be valid until authenticated by the manual signature of the Trustee or an authenticating agent. 

 

	 	(18)	ABBREVIATIONS. Customary abbreviations may be used in the name of a Holder or an assignee, such as: TEN COM (= tenants in common), TEN ENT (= tenants by the
entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST (= Custodian), and U/G/M/A (= Uniform Gifts to Minors Act). 

 

	 	(19)	CUSIP NUMBERS. Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification Procedures, the Company has caused CUSIP numbers to be
printed on the Notes, and the Trustee may use CUSIP numbers in notices of redemption as a convenience to Holders. No representation is made as to the accuracy of such numbers either as printed on the Notes or as contained in any notice of
redemption, and reliance may be placed only on the other identification numbers placed thereon. 

  

	 	(20)	GOVERNING LAW. THE INTERNAL LAW OF THE STATE OF NEW YORK WILL GOVERN AND BE USED TO CONSTRUE THE INDENTURE AND THIS NOTE WITHOUT GIVING EFFECT TO APPLICABLE PRINCIPLES
OF CONFLICTS OF LAW TO THE EXTENT THAT THE APPLICATION OF THE LAWS OF ANOTHER JURISDICTION WOULD BE REQUIRED THEREBY. 

 The Company will furnish to any Holder upon written request and without charge a copy of the Indenture and/or the Officers’ Certificate. 

Requests may be made to: 
 Amgen Inc. 
 One Amgen Center Drive 

Thousand Oaks, CA 91320-1799 
 Attention: Investor Relations 

 ASSIGNMENT FORM 

To assign this Note, fill in the form below: 
  

	
	(I) or (we) assign and transfer this Note to:
                                         
                   
	         (Insert assignee’s legal name)

	  

	(Insert assignee’s soc. sec. or tax I.D. no.)
	  

 
  

 

	 (Print or type assignee’s name, address and zip code)

 
 and irrevocably appoint
                                         
                                         
                                         
                                         
    
 to transfer this Note on the books of the Company. The agent may substitute another to act for him.

 

	
	Date:                     
	
	Your Signature:
                                         
                                         
                  
	(Sign exactly as your name appears on the face of this Note)
	
	  
 Signature Guarantee*:
                                         
           

	
	 *  Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to the
Trustee)

 Annex D 
 Form of 2041 Note 

 [Face of Note] 

 
 CUSIP 031162 BK5 

5.15% Senior Notes due 2041 
  

			
	No.             	 	$            

 AMGEN INC. 
 promises to pay to CEDE & CO. or registered assigns, 
 the principal sum of
             DOLLARS on November 15, 2041. 
 Interest Payment
Dates: May 15 and November 15 
 Record Dates: 15th day prior to May 15 and November 15 
 Dated:              
  

			
	AMGEN INC.
		
	By:	 	  

		 	Name:
		 	Title:
		
	By:	 	  

		 	Name:
		 	Title:

  

			
	 This is one of the Notes referred to
 in the within-mentioned Indenture:

	
	 The Bank of New York Mellon,
   as Trustee

		
	By:	 	  

		 	Authorized Officer

 [REVERSE SIDE OF NOTE] 

5.15% SENIOR NOTES DUE 2041 
 THIS SECURITY IS A GLOBAL SECURITY WITHIN THE MEANING OF THE INDENTURE HEREINAFTER REFERRED TO AND IS REGISTERED IN THE NAME OF THE DEPOSITORY OR A NOMINEE OF THE DEPOSITORY. THIS SECURITY IS EXCHANGEABLE
FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE ONLY IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITORY TO A NOMINEE OF THE DEPOSITORY,
BY A NOMINEE OF THE DEPOSITORY TO THE DEPOSITORY OR ANOTHER NOMINEE OF THE DEPOSITORY OR BY THE DEPOSITORY OR ANY SUCH NOMINEE TO A SUCCESSOR DEPOSITORY OR A NOMINEE OF SUCH A SUCCESSOR DEPOSITORY. 

UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY TO THE ISSUER OR ITS AGENT FOR
REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY (AND ANY PAYMENT HEREON
IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE
REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN. 
 Capitalized terms used herein have the meanings
assigned to them in the Indenture referred to below unless otherwise indicated. 
  

	 	(1)	INTEREST. Amgen Inc., a Delaware corporation (the “Company”), promises to pay interest on the principal amount of this Note at 5.15% per annum
from November 10, 2011 until maturity. The Company will pay interest in cash semi-annually in arrears on May 15 and November 15 of each year, or if any such day is not a Business Day, on the next succeeding Business Day (each, an
“Interest Payment Date”). Interest on the Notes will accrue from the most recent date to which interest has been paid or, if no interest has been paid, from the date of issuance; provided that the first Interest Payment Date
shall be May 15, 2012; provided further that after May 15, 2012, if there is no existing Default in the payment of interest, and if this Note is authenticated between a record date referred to on the face hereof and the next
succeeding Interest Payment Date, interest shall accrue from such next succeeding Interest Payment Date. 

  

	 	(2)	METHOD OF PAYMENT. The Company will pay interest on the Notes (except defaulted interest) to the Persons who are registered Holders of Notes at the close of business on
the day that is 15 days prior to the next succeeding Interest Payment Date (whether or not such day is a Business Day), even if such Notes are canceled after such record date and on or before such Interest Payment Date, except as provided in
Section 2.13 of the Indenture with respect to defaulted interest. The Notes will be payable as to principal and interest at the office or agency of the Company maintained for such purpose in the Borough of Manhattan, the City and State of New
York (or, if the Company fails to maintain such office or agency, at the corporate trust office of the trustee in New York, New York or if the trustee does not maintain an office in New York, at the office of a paying agent in New York), or, at the
option of the Company, payment of interest may be made by check mailed to the Holders at their addresses set forth in the register of Holders; provided that payment by wire transfer of immediately available funds will be required with respect to
principal of and interest on all Global Securities and all other Notes the Holders of which will have provided wire transfer instructions to the Company or the Paying Agent. Such payment will be in the currency of the United States of America.

	 	(3)	PAYING AGENT AND REGISTRAR. Initially, The Bank of New York Mellon (as successor to JPMorgan Chase Bank, N.A.), the Trustee under the Indenture, will act as Paying
Agent and Registrar. The Company may change any Paying Agent or Registrar without notice to any Holder. The Company or any of its Subsidiaries may act in any such capacity. 

 

	 	(4)	INDENTURE. The terms of the Notes include those stated in the Indenture dated August 4, 2003, between the Company and the Trustee (the
“Indenture”), and those made part of the Indenture by the Officers’ Certificate dated November 10, 2011, delivered pursuant thereto (the “Officers’ Certificate”) and the TIA. The Notes are subject to
all such terms, and the Holders are referred to the Indenture and the TIA for a statement of them. 

  

	 	(5)	OPTIONAL REDEMPTION. At any time prior to maturity, the Company will have the option to redeem all or a part of the Notes upon not less than 30 nor more than 60
days’ notice. If the Notes are redeemed before May 15, 2041 (six months prior to the maturity date of the Notes) the redemption price will equal the sum of (1) 100% of the principal amount being redeemed, plus accrued and unpaid
interest to, but not including, the redemption date, and (2) the Make-Whole Amount. If the Notes are redeemed on or after May 15, 2041 (six months prior to the maturity date of the Notes), the redemption price will equal 100% of the
principal amount being redeemed, plus accrued and unpaid interest to, but not including, the redemption date. Unless the Company defaults in the payment of the redemption price, interest will cease to accrue on the Notes or portions thereof called
for redemption on the applicable redemption date. 

  

	 	(6)	NOTICE OF REDEMPTION. Notice of redemption will be mailed at least 30 days but not more than 60 days before the redemption date to each Holder whose Notes are to be
redeemed at its registered address, except that redemption notices may be mailed more than 60 days prior to a redemption date if the notice is issued in connection with a defeasance of the Notes or a satisfaction or discharge of the Indenture. Notes
in denominations larger than $2,000 may be redeemed in part but only in whole multiples of $1,000, unless all of the Notes held by a Holder are to be redeemed. 

 

	 	(7)	MANDATORY REDEMPTION. Except as provided in Section 8 below, the Company is not required to make mandatory redemption or sinking fund payments with respect to the
Notes. 

  

	 	(8)	CHANGE OF CONTROL TRIGGERING EVENT. In the event of a Change of Control Triggering Event, the Holders may require the Company to purchase for cash all or a portion of
their Notes at a purchase price equal to 101% of the principal amount of the notes, plus accrued and unpaid interest, if any, pursuant to the provisions of Section 7 of the Officers’ Certificate. 

	 	(9)	DEFEASANCE PRIOR TO MATURITY. The Indenture contains provisions for defeasance of (i) the entire indebtedness of the Notes or (ii) certain covenants and
Events of Default with respect to the Notes, in each case upon compliance with certain conditions set forth therein. 

  

	 	(10)	RESTRICTIVE COVENANTS. The Indenture and the Officers’ Certificate impose certain limitations on the Company and its Subsidiaries, including limitations on the
Company’s and its Subsidiaries’ ability to create or incur certain Liens on any of their respective properties or assets and to enter into certain sale and lease-back transactions and on the Company’s ability to engage in mergers or
consolidations or the conveyance, transfer or lease of all or substantially all of its properties and assets. These limitations are subject to a number of important qualifications and exceptions and reference is made to the Indenture and the
Officers’ Certificate for a description thereof. 

  

	 	(11)	DENOMINATIONS, TRANSFER, EXCHANGE. The Notes are in registered form without coupons in denominations of $2,000 and integral multiples of $1,000. The transfer of Notes
may be registered and Notes may be exchanged as provided in the Indenture. The Registrar and the Trustee may require a Holder, among other things, to furnish appropriate endorsements and transfer documents and the Company may require a Holder to pay
any taxes and fees required by law or permitted by the Indenture. The Company need not exchange or register the transfer of any Note or portion of a Note selected for redemption, except for the unredeemed portion of any Note being redeemed in part.
Also, the Company need not exchange or register the transfer of any Notes for a period of 15 days before a selection of Notes to be redeemed or during the period between a record date and the corresponding Interest Payment Date.

  

	 	(12)	PERSONS DEEMED OWNERS. The registered Holder of a Note may be treated as its owner for all purposes. 

 

	 	(13)	AMENDMENT, SUPPLEMENT AND WAIVER. Subject to certain exceptions, the Indenture or the Notes may be amended or supplemented with the consent of the Holders of at least a
majority in aggregate principal amount of the then outstanding Notes voting as a single class, and any existing Default or Event or Default or compliance with any provision of the Indenture or the Notes may be waived with the consent of the Holders
of a majority in aggregate principal amount of the then outstanding Notes voting as a single class. Without the consent of any Holder of a Note, the Indenture or the Notes may be amended or supplemented to cure any ambiguity, defect or
inconsistency, to comply with Article V of the Indenture, to provide for uncertificated Notes in addition to or in place of certificated Notes, to make any change that would not adversely affect the rights under the Indenture of any such Holder, to
provide for the issuance of any additional notes as permitted by the Indenture, to appoint a successor trustee with respect to the notes and to add to or change any of the provisions of the Indenture necessary to provide for the administration of
the trusts in the Indenture by more than one trustee, or to comply with the requirements of the SEC in order to effect or maintain the qualification of the Indenture under the TIA. No amendment to cure any ambiguity, defect or inconsistency in the
Indenture made solely to conform the Indenture to the description of notes contained in the Prospectus Supplement related to the Notes, dated November 7, 2011, will be deemed to adversely affect the interests of the Holders of the Notes.

  

	 	(14)	DEFAULTS AND REMEDIES. If an Event of Default shall occur and be continuing, the principal of the Notes may be declared (or, in certain cases, shall ipso facto become)
due and payable in the manner and with the effect provided in the Indenture. 

	 	(15)	TRUSTEE DEALINGS WITH COMPANY. The Trustee under the Indenture, in its individual or any other capacity, may deal with the Company or an Affiliate of the Company with
the same rights it would have if it were not Trustee. 

  

	 	(16)	NO RECOURSE AGAINST OTHERS. A director, officer, employee or stockholder of the Company shall not have any liability for any obligations of the Company under the Notes
or the Indenture or for any claim based on, in respect of, or by reason of, such obligations or their creation. Each Holder by accepting a Note waives and releases all such liability. The waiver and release are part of the consideration for the
issuance of the Notes. 

  

	 	(17)	AUTHENTICATION. This Note will not be valid until authenticated by the manual signature of the Trustee or an authenticating agent. 

 

	 	(18)	ABBREVIATIONS. Customary abbreviations may be used in the name of a Holder or an assignee, such as: TEN COM (= tenants in common), TEN ENT (= tenants by the
entireties), JT TEN (= joint tenants with right of survivorship and not as tenants in common), CUST (= Custodian), and U/G/M/A (= Uniform Gifts to Minors Act). 

 

	 	(19)	CUSIP NUMBERS. Pursuant to a recommendation promulgated by the Committee on Uniform Security Identification Procedures, the Company has caused CUSIP numbers to be
printed on the Notes, and the Trustee may use CUSIP numbers in notices of redemption as a convenience to Holders. No representation is made as to the accuracy of such numbers either as printed on the Notes or as contained in any notice of
redemption, and reliance may be placed only on the other identification numbers placed thereon. 

  

	 	(20)	GOVERNING LAW. THE INTERNAL LAW OF THE STATE OF NEW YORK WILL GOVERN AND BE USED TO CONSTRUE THE INDENTURE AND THIS NOTE WITHOUT GIVING EFFECT TO APPLICABLE PRINCIPLES
OF CONFLICTS OF LAW TO THE EXTENT THAT THE APPLICATION OF THE LAWS OF ANOTHER JURISDICTION WOULD BE REQUIRED THEREBY. 

 The Company will furnish to any Holder upon written request and without charge a copy of the Indenture and/or the Officers’ Certificate. 

Requests may be made to: 
 Amgen Inc. 
 One Amgen Center Drive 

Thousand Oaks, CA 91320-1799 
 Attention: Investor Relations 

 ASSIGNMENT FORM 

To assign this Note, fill in the form below: 
  

	
	(I) or (we) assign and transfer this Note to:
                                         
                   
	         (Insert assignee’s legal name)

	  

	(Insert assignee’s soc. sec. or tax I.D. no.)
	  

 
  

 

	 (Print or type assignee’s name, address and zip code)

 
 and irrevocably appoint
                                         
                                         
                                         
                                         
    
 to transfer this Note on the books of the Company. The agent may substitute another to act for him.

 

	
	Date:                     
	
	Your Signature:
                                         
                                         
                  
	(Sign exactly as your name appears on the face of this Note)
	
	  
 Signature Guarantee*:
                                         
           

	
	 *  Participant in a recognized Signature Guarantee Medallion Program (or other signature guarantor acceptable to the
Trustee)EX-4.1

 EXHIBIT 4.1 

 
  
 ZIMMER HOLDINGS, INC. 
 $250,000,000 1.400% Notes due 2014

 $300,000,000 3.375% Notes due 2021 
 SECOND SUPPLEMENTAL INDENTURE 
 Dated as of November 10, 2011

 to 
 Indenture dated as of November 17, 2009 
 WELLS FARGO BANK, NATIONAL
ASSOCIATION 
 Trustee 
  

 

 CONTENTS 

 

									
	Clause	  	 	  	 	  	Page	 
			
	 ARTICLE I
	  	 DEFINITIONS AND INCORPORATION BY REFERENCE
	  	 	1	  
			
	 SECTION 1.01.
	  	 Application of this Second Supplemental Indenture
	  	 	1	  
			
	 SECTION 1.02.
	  	 Definitions
	  	 	2	  
			
	 SECTION 1.03.
	  	 Incorporation by Reference of Trust Indenture Act
	  	 	5	  
			
	 ARTICLE II
	  	 CREATION, FORMS, TERMS AND CONDITIONS OF THE SECURITIES
	  	 	5	  
			
	 SECTION 2.01.
	  	 Creation of the Notes
	  	 	5	  
			
	 SECTION 2.02.
	  	 Form of the Notes
	  	 	5	  
			
	 SECTION 2.03.
	  	 Terms and Conditions of the 2014 Notes
	  	 	6	  
			
	 SECTION 2.04.
	  	 Terms and Conditions of the 2021 Notes
	  	 	7	  
			
	 SECTION 2.05.
	  	 Ranking
	  	 	8	  
			
	 SECTION 2.06.
	  	 Sinking Fund
	  	 	8	  
			
	 ARTICLE III
	  	 REDEMPTION
	  	 	8	  
			
	 SECTION 3.01.
	  	 Optional Redemption
	  	 	8	  
			
	 ARTICLE IV
	  	 CHANGE OF CONTROL
	  	 	9	  
			
	 SECTION 4.01.
	  	 Repurchase at the Option of Holders Upon a Change of Control Repurchase Event
	  	 	9	  
			
	 ARTICLE V
	  	 TRANSFER AND EXCHANGE
	  	 	11	  
			
	 SECTION 5.01.
	  	 Transfer and Exchange
	  	 	11	  
			
	 ARTICLE VI
	  	 TRUSTEE
	  	 	12	  
			
	 SECTION 6.01.
	  	 Corporate Trust Office
	  	 	12	  
			
	 SECTION 6.02.
	  	 Recitals of Fact
	  	 	12	  
			
	 SECTION 6.03.
	  	 Successor
	  	 	12	  
			
	 ARTICLE VII
	  	 MISCELLANEOUS PROVISIONS
	  	 	12	  
			
	 SECTION 7.01.
	  	 Ratification of Original Indenture
	  	 	12	  
			
	 SECTION 7.02.
	  	 Effect of Headings
	  	 	12	  
			
	 SECTION 7.03.
	  	 Successors and Assigns
	  	 	12	  
			
	 SECTION 7.04.
	  	 Separability Clause
	  	 	12	  
			
	 SECTION 7.05.
	  	 Governing Law
	  	 	13	  
			
	 SECTION 7.06.
	  	 Counterparts
	  	 	13	  

  
 i 

 CONTENTS 

 

			
	EXHIBITS
		
	EXHIBIT A	  	Form of Global 2014 Note
	EXHIBIT B	  	Form of Global 2021 Note

  
 ii 

 SECOND SUPPLEMENTAL INDENTURE, dated as of November 10, 2011 (this “Second
Supplemental Indenture”), between ZIMMER HOLDINGS, INC., a corporation duly organized and existing under the laws of the State of Delaware (herein called the “Company” or the “Issuer”), having its principal offices at 345
East Main Street, Warsaw, Indiana, and WELLS FARGO BANK, NATIONAL ASSOCIATION, a national banking association, as trustee (the “Trustee”). 
 RECITALS 
 WHEREAS, the Issuer executed and delivered to the Trustee
an Indenture, dated as of November 17, 2009 (the “Original Indenture”), providing for the issuance by the Issuer from time to time of debt securities evidencing unsecured and unsubordinated indebtedness of the Issuer to be issued in
one or more series; 
 WHEREAS, the Original Indenture provides, among other things, that by means of a supplemental
indenture, the Issuer and the Trustee may, without the consent of Holders, create one or more series of the Issuer’s debt securities and establish the form and terms and conditions thereof; 

WHEREAS, the Issuer intends by this Second Supplemental Indenture to create and provide for the issuance of new series of debt
securities to be designated as the “1.400% Notes due 2014” (the “2014 Notes”) and the “3.375% Notes due 2021” (the “2021 Notes” and, together with the 2014 Notes, the “Notes”); 

WHEREAS, the Board of Directors of the Issuer has authorized the execution and delivery of the Second Supplemental Indenture, the
issuance of the Notes and the forms, terms and conditions of the Notes pursuant to Sections 201, 301 and 901 of the Original Indenture; and 
 WHEREAS, all acts and things necessary to make the Notes, when the Notes have been executed by the Issuer, authenticated by the Trustee, issued upon the terms and subject to the conditions set
forth hereinafter and in the Original Indenture and delivered as provided in the Indenture against payment therefor, valid, binding and legal obligations of the Issuer according to their terms, and all actions required to be taken by the Issuer
under the Original Indenture to make this Second Supplemental Indenture a valid, binding and legal agreement of the Issuer, have been done; 
 NOW, THEREFORE, in consideration of the premises and for other good and valuable consideration, the sufficiency and adequacy of which are hereby acknowledged, the parties hereto hereby agree as
follows: 
 ARTICLE I 
 DEFINITIONS AND INCORPORATION BY REFERENCE 
 SECTION 1.01. Application
of this Second Supplemental Indenture. Notwithstanding any other provision of this Second Supplemental Indenture, the provisions of this Second Supplemental Indenture, including the covenants set forth herein, are expressly and solely for the

 
benefit of the Notes. The Notes constitute two separate series of notes as provided in Section 301 of the Original Indenture. 

SECTION 1.02. Definitions. Capitalized terms used in this Second Supplemental Indenture and not otherwise defined herein shall
have the meanings ascribed to them in the Original Indenture. In addition, the following terms shall have the following meanings to be equally applicable to both the singular and the plural forms of the terms defined: 

“2014 Interest Payment Date” has the meaning set forth in Section 2.03(c). 

“2021 Interest Payment Date” has the meaning set forth in Section 2.04(c). 

“2014 Maturity Date” has the meaning set forth in Section 2.03(b). 

“2021 Maturity Date” has the meaning set forth in Section 2.04(b). 

“2014 Notes” has the meaning set forth in the Recitals hereto. 

“2021 Notes” has the meaning set forth in the Recitals hereto. 

“2014 Regular Record Date” has the meaning set forth in Section 2.03(c). 

“2021 Regular Record Date” has the meaning set forth in Section 2.04(c). 

“Below Investment Grade Rating Event” means the Notes are rated below Investment Grade by each of the Rating Agencies on
any date from the date of the public notice of an arrangement that could result in a Change of Control until the end of the 60-day period following public notice of the occurrence of a Change of Control (which period shall be extended so long as the
rating of the Notes is under publicly announced consideration for possible downgrade by any of the Rating Agencies); provided that a Below Investment Grade Rating Event otherwise arising by virtue of a particular reduction in rating shall not
be deemed to have occurred in respect of a particular Change of Control (and thus shall not be deemed a Below Investment Grade Rating Event for purposes of the definition of Change of Control Repurchase Event hereunder) if the Rating Agencies making
the reduction in rating to which this definition would otherwise apply do not announce or publicly confirm or inform the Issuer that the reduction was the result, in whole or in part, of any event or circumstance comprised of or arising as a result
of, or in respect of, the applicable Change of Control (whether or not the applicable Change of Control shall have occurred at the time of the Below Investment Grade Rating Event). 

“Business Day” means any day, other than a Saturday or Sunday, that is neither a legal holiday nor a day on which the
Trustee or banking institutions in The City of New York are authorized or required by law or regulation to close. 

“Change of Control” means the occurrence of any of the following: 

(1) the direct or indirect sale, transfer, conveyance or other disposition (other than by way of merger or consolidation),
in one or a series of related transactions, of all or substantially all of the properties or assets of the Issuer and its subsidiaries taken as a 

  
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whole to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other than the Issuer or one of its subsidiaries; 

(2) the adoption of a plan relating to the Issuer’s liquidation or dissolution; 

(3) the first day on which a majority of the members of the Issuer’s Board of Directors are not Continuing Directors;
or 
 (4) the consummation of any transaction or series of related transactions (including, without limitation,
any merger or consolidation) the result of which is that any “person” (as that term is used in Section 13(d)(3) of the Exchange Act), other than the Issuer or one or more of its wholly-owned subsidiaries becomes the beneficial owner,
directly or indirectly, of more than 50% of the then outstanding number of shares of the Issuer’s Voting Stock. 

“Change of Control Repurchase Event” means the occurrence of both a Change of Control and a Below Investment Grade
Rating Event. 
 “Comparable Treasury Issue” means the United States Treasury security selected by the
Quotation Agent as having a maturity comparable to the remaining term of the series of Notes to be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt
securities of comparable maturity to the remaining term of such Notes. 
 “Comparable Treasury Price” means,
with respect to any Redemption Date, (1) the average of four Reference Treasury Dealer Quotations for such Redemption Date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, (2) if the Issuer can only obtain
less than four such Reference Treasury Dealer Quotations, the average of all such quotations or (3) if the Issuer can only obtain one Reference Treasury Dealer Quotation, such quotation. 

“Continuing Directors” means, as of any date of determination, any member of the Issuer’s Board of Directors who
(1) was a member of such Board of Directors on the date of the issuance of the Notes; or (2) was nominated for election or elected to such Board of Directors with the approval of a majority of the Continuing Directors who were members of
such Board of Directors at the time of such nomination or election (either by a specific vote or by approval of the Issuer’s proxy statement in which such member was named as a nominee for election as a director). 

“Dollar” and “$” means the lawful currency of the United States of America. 

“DTC” means The Depository Trust Company, its nominees and their successors and assigns. 

“Exchange Act” means the Securities Exchange Act of 1934, as amended from time to time. 

  
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 “Global Note” means a single permanent fully-registered global note in
book-entry form, without coupons, substantially in the form of Exhibit A and Exhibit B attached hereto. 

“Indenture” means the Original Indenture as supplemented by this Second Supplemental Indenture. 

“Investment Grade” means a rating of Baa3 or better by Moody’s (or its equivalent under any successor rating
categories of Moody’s) and a rating of BBB- or better by S&P (or its equivalent under any successor rating categories of S&P) or the equivalent investment grade credit rating from any additional Rating Agency or Rating Agencies selected
by the Issuer. 
 “Issuer” has the meaning set forth in the Recitals hereto. 

“Moody’s” means Moody’s Investors Service Inc. 

“Notes” has the meaning set forth in the Recitals hereto. 

“Original Indenture” has the meaning set forth in the Recitals hereto. 

“Quotation Agent” means the Reference Treasury Dealer appointed by the Issuer, 

“Rating Agency” means (1) each of Moody’s and S&P; and (2) if any of Moody’s or S&P ceases
to rate the Notes or fails to make a rating of the Notes publicly available for reasons outside of the Issuer’s control, a “nationally recognized statistical rating organization” within the meaning of Rule 15c3-1(c)(2)(vi)(F) under
the Exchange Act, selected by the Issuer as a replacement agency for Moody’s or S&P, as the case may be. 

“Redemption Date” means the Business Day on which Notes are redeemed by the Issuer pursuant to Section 3.01 hereof.

 “Reference Treasury Dealer” means (1) each of BNP Paribas Securities Corp., Merrill Lynch, Pierce,
Fenner & Smith Incorporated and RBS Securities Inc. (or their respective affiliates that are Primary Treasury Dealers) and their respective successors; provided, however, that if any of the foregoing shall cease to be a primary U.S.
Government securities dealer in New York City (a “Primary Treasury Dealer”), the Issuer will substitute therefor another Primary Treasury Dealer, and (2) another Primary Treasury Dealer selected by the Issuer. 

“Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any Redemption Date,
the average, as determined by the Issuer, of the bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted in writing to the Issuer by such Reference Treasury Dealer at 5:00 p.m.,
New York City time, on the third Business Day preceding such Redemption Date. 
 “Registered Securities” means
any Securities which are registered in the Security Register. 
 “S&P” means Standard &
Poor’s Ratings Services, a division of The McGraw-Hill Companies, Inc. 

  
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 “Treasury Rate” means, with respect to any Redemption Date, the rate per
annum equal to the semi-annual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such
Redemption Date. 
 “Trustee” has the meaning set forth in the Recitals hereto. 

“Voting Stock” means, with respect to any Person, capital stock of any class or kind the holders of which are
ordinarily, in the absence of contingencies, entitled to vote for the election of directors (or Persons performing similar functions) of such Person, even if the right so to vote has been suspended by the happening of such a contingency. 

SECTION 1.03. Incorporation by Reference of Trust Indenture Act. The Indenture is subject to the mandatory provisions of the Trust
Indenture Act, which are incorporated by reference in and made a part of the Indenture. The following Trust Indenture Act terms have the following meanings: 
 “indenture securities” means the Notes. 
 “indenture security
holder” means a Holder. 
 “indenture to be qualified” means this Second Supplemental Indenture. 

“indenture trustee” or “institutional trustee” means the Trustee. 

“obligor” on the indenture securities means the Issuer and any other obligor on the indenture securities. 

All other Trust Indenture Act terms used in this Indenture that are defined by the Trust Indenture Act, defined by Trust Indenture Act
reference to another statute or defined by Securities and Exchange Commission rule have the meanings assigned to them by such definitions. 
 ARTICLE II 
 CREATION, FORMS, 

TERMS AND CONDITIONS OF THE SECURITIES 
 SECTION 2.01. Creation of the Notes. In accordance with Section 301 of the Original Indenture, the Issuer hereby creates each of the 2014 Notes and the 2021 Notes as a separate series of its
securities issued pursuant to the Indenture. The 2014 Notes shall be issued initially in an aggregate principal amount of $250,000,000 and the 2021 Notes shall be issued initially in an aggregate principal amount of $300,000,000, except as permitted
by Sections 304, 305 or 306 of the Original Indenture. 
 SECTION 2.02. Form of the Notes. The Notes shall each be issued
in the form of a Global Note, duly executed by the Issuer and authenticated by the Trustee, which shall be deposited with the Trustee as custodian for DTC and registered in the name of “Cede & Co.,” as

  
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the nominee of DTC. The 2014 Notes shall be substantially in the form of Exhibit A attached hereto, and the 2021 Notes shall be substantially in the form of Exhibit B attached hereto. So long as
DTC, or its nominee, is the registered owner of a Global Note, DTC or its nominee, as the case may be, shall be considered the sole owner or Holder of the Notes represented by such Global Note for all purposes under the Indenture. Ownership of
beneficial interests in such Global Note shall be shown on, and transfers thereof will be effected only through, records maintained by DTC (with respect to beneficial interests of participants) or by participants or Persons that hold interests
through participants (with respect to beneficial interests of beneficial owners). 
 SECTION 2.03. Terms and Conditions of
the 2014 Notes. The 2014 Notes shall be governed by all the terms and conditions of the Original Indenture, as supplemented by this Second Supplemental Indenture. In particular, the following provisions shall be terms of the 2014 Notes:

 (a) Title and Aggregate Principal Amount. The title of the 2014 Notes shall be as specified in the Recitals; and the
aggregate principal amount of the 2014 Notes shall be as specified in Section 2.01 of this Article II, except as permitted by Sections 304, 305 or 306 of the Original Indenture. 

(b) Stated Maturity. The 2014 Notes shall mature, and the unpaid principal thereon shall be payable, on November 30, 2014
(the “2014 Maturity Date”), subject to the provisions of the Original Indenture and Articles III and IV below. 
 (c)
Interest. The rate per annum at which interest shall be payable on the 2014 Notes shall be 1.400%. Interest on the 2014 Notes shall be payable semi-annually in arrears on each May 30 and November 30, commencing on May 30, 2012
(each, a “2014 Interest Payment Date”), to the Persons in whose names the applicable 2014 Notes are registered in the Security Register applicable to the 2014 Notes at the close of business on the immediately preceding May 15 or
November 15, respectively, prior to the applicable 2014 Interest Payment Date regardless of whether such day is a Business Day (each, a “2014 Regular Record Date”). Interest on the 2014 Notes shall be computed on the basis of a
360-day year consisting of twelve 30-day months. Interest on the 2014 Notes shall accrue from and including November 10, 2011. If a 2014 Interest Payment Date or the 2014 Maturity Date falls on a day that is not a Business Day, the payment will
be made on the next Business Day as if it were made on the date the payment was due, and no interest will accrue on the amount so payable for the period from and after that 2014 Interest Payment Date or the 2014 Maturity Date, as the case may be, to
the date the payment is made. Interest payments will include accrued interest from and including the date of issue or from and including the last date in respect to which interest has been paid, as the case may be, to, but excluding, the 2014
Interest Payment Date or the 2014 Maturity Date, as the case may be. 
 (d) Registration and Form. The 2014 Notes shall
be issuable as Registered Securities as provided in Section 2.02 of this Article II. The 2014 Notes shall be issued and may be transferred only in minimum denominations of $2,000 and integral multiples of $1,000 in excess thereof. All payments
of principal, redemption price and accrued unpaid interest in respect of the 2014 Notes shall be made by the Issuer in immediately available funds. 

  
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 (e) Defeasance and Covenant Defeasance. The provisions for defeasance in
Section 1302 of the Original Indenture, and the provisions for covenant defeasance in Section 1303 of the Original Indenture, shall be applicable to the 2014 Notes. 
 (f) Further Issues. Notwithstanding anything to the contrary contained herein or in the Original Indenture, the Issuer may, from time to time, without the consent of or notice to the Holders,
create and issue further securities having the same ranking and terms and conditions as the 2014 Notes in all respects, except for issue date, the public offering price and, in some cases, the first interest payment date. Additional 2014 Notes
issued in this manner shall be consolidated with and shall form a single series with the previously outstanding 2014 Notes. Notice of any such issuance shall be given to the Trustee and a new supplemental indenture shall be executed in connection
with the issuance of such additional 2014 Notes. 
 (g) Other Terms and Conditions. The 2014 Notes shall have such other
terms and conditions as provided in the form thereof attached as Exhibit A. 
 SECTION 2.04. Terms and Conditions of the 2021
Notes. The 2021 Notes shall be governed by all the terms and conditions of the Original Indenture, as supplemented by this Second Supplemental Indenture. In particular, the following provisions shall be terms of the 2021 Notes: 

(a) Title and Aggregate Principal Amount. The title of the 2021 Notes shall be as specified in the Recitals; and the aggregate
principal amount of the 2021 Notes shall be as specified in Section 2.01 of this Article II, except as permitted by Sections 304, 305 or 306 of the Original Indenture. 
 (b) Stated Maturity. The 2021 Notes shall mature, and the unpaid principal thereon shall be payable, on November 30, 2021 (the “2021 Maturity Date”), subject to the provisions of the
Original Indenture and Articles III and IV below. 
 (c) Interest. The rate per annum at which interest shall be payable
on the 2021 Notes shall be 3.375%. Interest on the 2021 Notes shall be payable semi-annually in arrears on each May 30 and November 30, commencing on May 30, 2012 (each, a “2021 Interest Payment Date”), to the Persons in
whose names the applicable 2021 Notes are registered in the Security Register applicable to the 2021 Notes at the close of business on the immediately preceding May 15 or November 15, respectively, prior to the applicable 2021 Interest
Payment Date regardless of whether such day is a Business Day (each, a “2021 Regular Record Date”). Interest on the 2021 Notes shall be computed on the basis of a 360-day year consisting of twelve 30-day months. Interest on the 2021 Notes
shall accrue from and including November 10, 2011. If a 2021 Interest Payment Date or the 2021 Maturity Date falls on a day that is not a Business Day, the payment will be made on the next Business Day as if it were made on the date the payment
was due, and no interest will accrue on the amount so payable for the period from and after that 2021 Interest Payment Date or the 2021 Maturity Date, as the case may be, to the date the payment is made. Interest payments will include accrued
interest from and including the date of issue or from and including the last date in respect to which interest has been paid, as the case may be, to, but excluding, the 2021 Interest Payment Date or the 2021 Maturity Date, as the case may be.

  
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 (d) Registration and Form. The 2021 Notes shall be issuable as Registered Securities
as provided in Section 2.02 of this Article II. The 2021 Notes shall be issued and may be transferred only in minimum denominations of $2,000 and integral multiples of $1,000 in excess thereof. All payments of principal, redemption price and
accrued unpaid interest in respect of the 2021 Notes shall be made by the Issuer in immediately available funds. 
 (e)
Defeasance and Covenant Defeasance. The provisions for defeasance in Section 1302 of the Original Indenture, and the provisions for covenant defeasance in Section 1303 of the Original Indenture, shall be applicable to the 2021
Notes. 
 (f) Further Issues. Notwithstanding anything to the contrary contained herein or in the Original Indenture, the
Issuer may, from time to time, without the consent of or notice to the Holders, create and issue further securities having the same ranking and terms and conditions as the 2021 Notes in all respects, except for issue date, the public offering price
and, in some cases, the first interest payment date. Additional 2021 Notes issued in this manner shall be consolidated with and shall form a single series with the previously outstanding 2021 Notes. Notice of any such issuance shall be given to the
Trustee and a new supplemental indenture shall be executed in connection with the issuance of such additional 2021 Notes. 
 (g)
Other Terms and Conditions. The 2021 Notes shall have such other terms and conditions as provided in the form thereof attached as Exhibit B. 
 SECTION 2.05. Ranking. The Notes shall be general unsecured obligations of the Issuer. The Notes shall rank pari passu in right of payment with all unsecured and unsubordinated indebtedness
of the Issuer and senior in right of payment to all subordinated indebtedness of the Issuer. 
 SECTION 2.06. Sinking
Fund. The Notes will not be entitled to any sinking fund. 
 ARTICLE III 

REDEMPTION 
 SECTION 3.01. Optional Redemption. 
 (a) The Notes are redeemable, in whole
or in part from time to time, at the option of the Issuer, at any time with respect to the 2014 Notes and at any time prior to August 30, 2021 (three months prior to the maturity date of the 2021 Notes) with respect to the 2021 Notes at a
redemption price equal to the greater of: 
 (i) 100% of the principal amount of the Notes to be redeemed on that Redemption
Date; and 
 (ii) the sum of the present values of the remaining scheduled payments of principal and interest on the Notes
being redeemed on that Redemption Date (not including any portion of such payments of interest accrued as of the Redemption Date), discounted to the Redemption Date on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day

  
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months) at the Treasury Rate, plus 15 basis points, in the case of the 2014 Notes, and 20 basis points, in the case of the 2021 Notes, 
 plus, in each case, accrued and unpaid interest thereon to the Redemption Date. 

The 2021 Notes are redeemable, in whole or in part from time to time, at the option of the Issuer, at any time on or after
August 30, 2021 (three months prior to the maturity date of the 2021 Notes) at a redemption price equal to 100% of the principal amount of the 2021 Notes to be redeemed on that Redemption Date, plus accrued and unpaid interest thereon to the
Redemption Date. 
 (b) Notwithstanding subsection (a) above, installments of interest on the Notes that are due and
payable on the 2014 Interest Payment Dates or the 2021 Interest Payment Dates, as the case may be, falling on or prior to a Redemption Date will be payable on such 2014 Interest Payment Date or 2021 Interest Payment Date to the registered Holders as
of the close of business on the relevant 2014 Regular Record Date or 2021 Regular Record Date, as the case may be, according to the terms of the Notes and the Indenture. Unless the Issuer defaults in payment of the redemption price, on and after the
Redemption Date, interest will cease to accrue on any Notes that are called for redemption. 
 (c) Notices of redemption will be
mailed at least 30 but not more than 60 days before the Redemption Date to each Holder of the Notes to be redeemed at its registered address. The Issuer will calculate the redemption price and will deliver an Officer’s Certificate to the
Trustee setting forth the redemption price no later than two Business Days prior to the Redemption Date. 
 (d) If less than all
the Notes of any series are to be redeemed at any time, the Notes to be redeemed will be selected by lot by DTC, in the case of Global Notes, or by the Trustee by a method the Trustee deems to be fair and appropriate, in the case of Notes that are
not represented by a Global Note. 
 ARTICLE IV 
 CHANGE OF CONTROL 
 SECTION 4.01. Repurchase at the Option of Holders
Upon a Change of Control Repurchase Event. 
 (a) If a Change of Control Repurchase Event occurs, unless the Issuer has
exercised its right to redeem the Notes pursuant to the Indenture, the Issuer will be required to make an offer to each Holder of the Notes to repurchase all or any part (in minimum denominations of $2,000 and integral multiples of $1,000 above that
amount) of that Holder’s Notes at a repurchase price in cash equal to 101% of the aggregate principal amount of the Notes repurchased plus any accrued and unpaid interest on the Notes repurchased to the date of repurchase. 

(b) Within 30 days following any Change of Control Repurchase Event or, at the option of the Issuer, prior to any Change of Control, but
after the public announcement of an 

  
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impending Change of Control, the Issuer will mail a notice to each Holder, with a copy to the Trustee, describing the transaction or transactions that constitute or may constitute the Change of
Control Repurchase Event and offering to repurchase the Notes on the payment date specified in the notice, which date will be no earlier than 30 days and no later than 60 days from the date such notice is mailed. The notice shall, if mailed prior to
the date of consummation of the Change of Control, state that the offer to purchase is conditioned on a Change of Control Repurchase Event occurring on or prior to the payment date specified in the notice. 

(c) The Issuer will comply with the requirements of Rule 14e-1 under the Exchange Act, and any other securities laws and regulations
thereunder, to the extent those laws and regulations are applicable in connection with the repurchase of the Notes as a result of a Change of Control Repurchase Event. To the extent that the provisions of any securities laws or regulations conflict
with the Change of Control Repurchase Event provisions of the Notes, the Issuer will comply with the applicable securities laws and regulations and will not be deemed to have breached its obligations under the Change of Control Repurchase Event
provisions of the Notes or the Indenture by virtue of such conflict. 
 (d) On the Change of Control Repurchase Event payment
date, the Issuer will, to the extent lawful: 
 (i) accept for payment all the Notes or portions of the Notes (in minimum
denominations of $2,000 and integral multiples of $1,000 above that amount) properly tendered pursuant to its offer; 
 (ii)
deposit on or before 10:00 a.m., New York City time, with the Paying Agent an amount equal to the aggregate purchase price in respect of all the Notes or portions of the Notes properly tendered; and 

(iii) deliver or cause to be delivered to the Trustee the Notes properly accepted, together with an Officer’s Certificate stating
the aggregate principal amount of Notes being purchased by the Issuer. 
 (e) The Paying Agent will promptly mail to each Holder
of Notes properly tendered the purchase price for the Notes, and the Trustee will promptly authenticate and mail (or, if a Global Note, to be adjusted on the Schedule of Exchanges attached thereto) to each Holder a new Note equal in principal amount
to any unpurchased portion of any Notes surrendered; provided, that each new Note will be in a principal amount of $2,000 or an integral multiple of $1,000 above that amount. 
 (f) The Issuer will not be required to make an offer to repurchase the Notes upon a Change of Control Repurchase Event if a third party makes such an offer in the manner, at the times and otherwise in
compliance with the requirements for an offer made by the Issuer and such third party purchases all Notes properly tendered and not withdrawn under its offer. 

  
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 ARTICLE V 
 TRANSFER AND EXCHANGE 
 SECTION 5.01. Transfer and Exchange.
Section 203(1) of the Original Indenture is replaced in its entirety by the following: 
 “SECTION
203. Transfer and Exchange. 
 (1) Transfer and Exchange of Global Securities. A Global Security
may not be transferred as a whole except by the Depository to a nominee of the Depository, by a nominee of the Depository to the Depository or to another nominee of the Depository, or by the Depository or any such nominee to a successor Depository
or a nominee of such successor Depository. The Company initially appoints The Depository Trust Company (“DTC”) to act as Depository with respect to the Global Securities. Global Securities shall be exchanged by the Company for Definitive
Securities if: 
 (A) the Company delivers to the Trustee notice from the Depository that it is unwilling or
unable to continue to act as Depository for the Global Securities and a successor Depository is not appointed by the Company within 90 days after the date of such notice from the Depository; 

(B) the Company delivers to the Trustee notice from the Depository that it is no longer a clearing agency registered under
the Exchange Act; 
 (C) the Company, in its sole discretion and subject to the procedures of the Depository,
determines that the Global Securities (in whole but not in part) should be exchanged for Definitive Securities and delivers written notice to such effect to the Trustee; or 

(D) there shall have occurred and be continuing an Event of Default under this Indenture and the Trustee has received a
request from the Depository or any Holder to issue Definitive Securities. 
 Upon the occurrence of any of the preceding events
in (A), (B) or (C) above, the Company will notify the Trustee in writing that, upon surrender by the Participants of their interest in such Global Securities, Definitive Securities will be issued to each Person that such Participants and
the Depository identify as being the beneficial owner of the related Securities. Beneficial interests in Global Securities may be exchanged for Definitive Securities of the same series upon request but only upon at least 30 days’ prior written
notice given to the Trustee by or on behalf of the Depository in accordance with customary procedures. Global Securities also may be exchanged or replaced, in whole or in part, as provided in Sections 304, 305 and 306 hereof. Except as otherwise
provided above in this Section 203, every Security authenticated and delivered in exchange for, or in lieu of, a Global Security or any portion thereof, pursuant to this Section 203 or Sections 304, 305 or 306 hereof, shall be
authenticated and delivered in the form of, and shall be, a Global Security. A Global Security may 

  
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not be exchanged for another Security other than as provided in this Section 203(1).” 
 ARTICLE VI 
 TRUSTEE 

SECTION 6.01. Corporate Trust Office. The Trustee is appointed as the principal paying agent, transfer agent and registrar for the
Notes and for the purposes of Section 1002 of the Indenture. The Notes may be presented for payment at the Paying Agent Office of the Trustee or at any other agency as may be appointed from time to time by the Issuer in The City of New York or
the City of Chicago. 
 SECTION 6.02. Recitals of Fact. The Trustee shall not be responsible in any manner whatsoever for
or in respect of the validity or sufficiency of this Second Supplemental Indenture or the due execution thereof by the Issuer. The recitals of fact contained herein shall be taken as the statements solely of the Issuer and the Trustee assumes no
responsibility for the correctness thereof. 
 SECTION 6.03. Successor. Any corporation or association into which the
Trustee may be merged or converted or with which it may be consolidated, or any corporation or association resulting from any merger, conversion or consolidation to which the Trustee shall be a party, or any corporation or association to which all
or substantially all of the corporate trust business of the Trustee may be sold or otherwise transferred, shall be the successor trustee hereunder without any further act. 
 ARTICLE VII 
 MISCELLANEOUS PROVISIONS 

SECTION 7.01. Ratification of Original Indenture. This Second Supplemental Indenture is executed and shall be construed as an
indenture supplemental to the Original Indenture, and as supplemented and modified hereby, the Original Indenture is in all respects ratified and confirmed, and the Original Indenture and this Second Supplemental Indenture shall be read, taken and
construed as one and the same instrument. 
 SECTION 7.02. Effect of Headings. The Article and Section headings herein
are for convenience only and shall not affect the construction hereof. 
 SECTION 7.03. Successors and Assigns. All
covenants and agreements in this Second Supplemental Indenture by the Issuer shall bind its successors and assigns, whether so expressed or not. 
 SECTION 7.04. Separability Clause. In case any one or more of the provisions contained in this Second Supplemental Indenture shall for any reason be held to be invalid, illegal or unenforceable in
any respect, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

  
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 SECTION 7.05. Governing Law. THIS SECOND SUPPLEMENTAL INDENTURE SHALL BE GOVERNED BY
AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 
 SECTION 7.06. Counterparts. This Second
Supplemental Indenture may be executed in any number of counterparts, and each of such counterparts shall for all purposes be deemed to be an original, but all such counterparts shall together constitute one and the same instrument. 

  
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 * * * * 
 IN WITNESS WHEREOF, the parties hereto have caused this Second Supplemental Indenture to be duly executed as of the date first above written. 

 

					
	ZIMMER HOLDINGS, INC.
		
	By:	 	 /s/ James T. Crines

		 	Name:	 	James T. Crines
		 	Title:	 	 Executive Vice President, Finance
 and Chief Financial Officer

	
	 WELLS FARGO BANK, NATIONAL ASSOCIATION,
 as Trustee

		
	By:	 	 /s/ Lynn M. Steiner

		 	Name:	 	Lynn M. Steiner
		 	Title:	 	Vice President

 Signature page to Supplemental Indenture 

 EXHIBIT A 
 FORM OF GLOBAL 2014 NOTE 
 [FACE OF GLOBAL NOTE] 

THIS GLOBAL NOTE IS HELD BY AND REGISTERED IN THE NAME OF THE DEPOSITORY (AS DEFINED IN THE INDENTURE GOVERNING THIS SECURITY), IS NOT EXCHANGEABLE
FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND IS NOT TRANSFERABLE TO ANY PERSON UNDER ANY CIRCUMSTANCES EXCEPT THAT (A) THE TRUSTEE
MAY MAKE SUCH NOTATIONS HEREON AS MAY BE REQUIRED PURSUANT TO SECTION 203 OF THE INDENTURE, (B) THIS GLOBAL NOTE MAY BE EXCHANGED PURSUANT TO SECTION 203(1) OF THE INDENTURE, (C) THIS GLOBAL NOTE MAY BE DELIVERED TO THE TRUSTEE FOR
CANCELLATION PURSUANT TO SECTION 309 OF THE INDENTURE AND (D) THIS GLOBAL NOTE MAY BE TRANSFERRED TO A SUCCESSOR DEPOSITORY WITH THE PRIOR WRITTEN CONSENT OF THE COMPANY. 
 UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER,
EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS
IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE, OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.

 CUSIP 98956P AD4 
 ZIMMER HOLDINGS, INC. 
 $250,000,000 1.400% Notes due 2014

  

			
	$250,000,000	  	No.: R-•

 Zimmer Holdings, Inc., a corporation duly organized and existing under the laws of the State of Delaware
(herein called the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to CEDE & CO., or registered assigns, the principal sum of TWO HUNDRED
FIFTY MILLION Dollars (or such other lesser or greater amount set forth on the Schedule of Exchanges of Interests in the Global Security attached hereto) on November 30, 2014, and to pay interest thereon from November 10, 2011 or from the
most recent Interest Payment Date to which interest has been paid or duly provided for, semi-annually on May 30 and November 30 each year, commencing on May 30, 2012, at the rate of 1.400% per annum, until the principal hereof is
paid or made 

  
 A-1

 
available for payment. The interest so payable, and punctually paid or duly provided for, on any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name
this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall be the May 15 or the November 15 (whether or not a Business Day), as the case may be,
next preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder on such Regular Record Date and may either be paid to the Person in whose name this Security
(or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be fixed by the Trustee, notice whereof shall be given to Holder of Securities of this series not
less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any securities exchange on which the Securities of this series may be listed, and upon such notice as
may be required by such exchange, all as more fully provided in said Indenture. 
 Payment of the principal of (and premium, if
any) and any such interest on this Security will be made at the office or agency of the Company maintained for that purpose at the Paying Agent Office of the Trustee, in such coin or currency of the United States of America as at the time of payment
is legal tender for payment of public and private debts; provided, however, that at the option of the Company payment of interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in
the Security Register. 
 Reference is hereby made to the further provisions of this Security set forth on the reverse hereof,
which further provisions shall for all purposes have the same effect as if set forth at this place. 
 Unless the certificate of
authentication hereon has been executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 A-2

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

					
	ZIMMER HOLDINGS, INC.
		
	By:	 	  

		 	Name:	 	James T. Crines
		 	Title:	 	Executive Vice President, Finance
		 		 	and Chief Financial Officer

  

			
	Attest:	 	
	
	  

	Name:	 	Heather J. Kidwell
	Title:	 	Senior Corporate Counsel and
		 	Assistant Secretary

  
 A-3

 CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. 

Dated: November 10, 2011 
  

			
	 Wells Fargo Bank, National Association
 as Trustee

		
	By:	 	  

		 	Authorized Signatory

  
 A-4

 [FORM OF REVERSE OF NOTE] 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be
issued in one or more series under an Indenture, dated as of November 17, 2009 (herein called the “Indenture”, which term shall have the meaning assigned to it in such instrument), between the Company and Wells Fargo Bank, National
Association, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and
immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof, limited
in aggregate principal amount to $250,000,000. 
 The Securities of this series are subject to redemption at any time, upon not
less than 30 days’ and not more than 60 days’ notice by mail, as a whole or from time to time in part, at the election of the Company (provided, however, that, if the Company shall have elected pursuant to the Indenture to
defease the entire Indebtedness of this Security or certain restrictive covenants and Events of Defaults with respect to this Security, prior to making such election to redeem the Securities it shall have deposited in trust amounts sufficient to pay
the redemption price), on any date prior to their Stated Maturity at a redemption price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed, plus accrued and unpaid interest thereon to the Redemption Date
and (ii) the sum of the present values of the Remaining Scheduled Payments (as defined below) of such Securities to be redeemed, discounted to the Redemption Date on a semi-annual basis (assuming a 360-day year consisting of twelve 30-day
months) at the Treasury Rate (as defined below), plus 15 basis points, plus accrued and unpaid interest thereon to the Redemption Date. 
 “Treasury Rate” means, with respect to any Redemption Date, the rate per annum equal to the semi-annual equivalent yield to maturity of the Comparable Treasury Issue, assuming a price for
the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. 
 “Comparable Treasury Issue” means the United States Treasury security selected by the Quotation Agent as having a maturity comparable to the remaining term of the series of Securities to
be redeemed that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining term of such Securities. 

“Comparable Treasury Price” means, with respect to any Redemption Date, (1) the average of four Reference Treasury
Dealer Quotations for such Redemption Date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, (2) if the Company can only obtain less than four such Reference Treasury Dealer Quotations, the average of all such
quotations or (3) if the Company can only obtain one Reference Treasury Dealer Quotation, such quotation. 

“Quotation Agent” means the Reference Treasury Dealer appointed by the Company. 

  
 A-5

 “Reference Treasury Dealer” means (1) each of BNP Paribas Securities
Corp., Merrill Lynch, Pierce, Fenner & Smith Incorporated and RBS Securities Inc. (or their respective affiliates that are Primary Treasury Dealers) and their respective successors; provided, however, that if any of the
foregoing shall cease to be a primary U.S. Government securities dealer in New York City (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer, and (2) another Primary Treasury Dealer
selected by the Company. 
 “Reference Treasury Dealer Quotations” means, with respect to each Reference
Treasury Dealer and any Redemption Date, the average, as determined by the Company, of the bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted in writing to the Company by
such Reference Treasury Dealer at 5:00 p.m., New York City time, on the third Business Day preceding such Redemption Date. 

“Remaining Scheduled Payments” means, with respect to each Security to be redeemed, the remaining scheduled payments of
the principal thereof and interest thereon that would be due after the related Redemption Date for such redemption; provided, however, that, if such Redemption Date is not an Interest Payment Date with respect to such Security, the
amount of the next succeeding scheduled interest payment thereon will be reduced by the amount of interest accrued thereon to such Redemption Date. 
 In the event of redemption of this Security in part only, a new Security or Securities of this series and of like tenor for the unredeemed portion hereof will be issued in the name of the Holder hereof
upon the cancellation hereof. 
 If a Change of Control Repurchase Event occurs, unless the Company has exercised its right to
redeem the Securities of this series pursuant to the Indenture, the Company will be required to make an offer to each Holder of the Securities of this series to repurchase all or any part (in minimum denominations of $2,000 and integral multiples of
$1,000 above that amount) of that Holder’s Securities of this series at a repurchase price in cash equal to 101% of the aggregate principal amount of such Securities repurchased plus any accrued and unpaid interest on such Securities
repurchased to the date of repurchase, in accordance with and pursuant to the terms and conditions set forth in the Indenture. 

The Indenture contains provisions for defeasance at any time of the entire Indebtedness of this Security or certain restrictive covenants
and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 
 If an Event of Default with respect to Securities of this series shall occur and be continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the
effect provided in the Indenture. 
 The Indenture permits, with certain exceptions as therein provided, the amendment thereof
and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a
majority in principal amount of the Securities at the time Outstanding of each series to be affected. The Indenture also contains provisions permitting the Holders of specified percentages in principal amount of the Securities

  
 A-6

 
of each series at the time Outstanding, on behalf of the Holders of all Securities of such series, to waive compliance by the Company with certain provisions of the Indenture and certain past
defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the
registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 
 As provided in and subject to the provisions of the Indenture, the Holder of this Security shall not have the right to institute any proceeding with respect to the Indenture or for the appointment of a
receiver or trustee or for any other remedy thereunder, unless such Holder shall have previously given the Trustee written notice of a continuing Event of Default with respect to the Securities of this series, the Holders of not less than 25% in
principal amount of the Securities of this series at the time Outstanding shall have made written request to the Trustee to institute proceedings in respect of such Event of Default as Trustee and offered the Trustee indemnity or security reasonably
satisfactory to it, and the Trustee shall not have received from the Holders of a majority in principal amount of Securities of this series at the time Outstanding a direction inconsistent with such request, and shall have failed to institute any
such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this Security for the enforcement of any payment of principal hereof or any premium or
interest hereon on or after the respective due dates expressed herein. 
 No reference herein to the Indenture and no provision
of this Security or of the Indenture shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of and any premium and interest on this Security at the times, place and rate, and in the coin or
currency, herein prescribed. 
 As provided in the Indenture and subject to certain limitations therein set forth, the transfer
of this Security may be registered and this Security may be exchanged as provided in the Indenture. 
 The Securities of this
series are issuable only in registered form without coupons in minimum denominations of $2,000 and any integral multiple of $1,000 in excess thereof. 
 No service charge shall be made for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental charge payable in
connection therewith. 
 Prior to due presentment of this Security for registration of transfer, the Company, the Trustee and
any agent of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be overdue, and neither the Company, the Trustee nor any such agent shall be
affected by notice to the contrary. 
 All terms used in this Security which are defined in the Indenture shall have the
meanings assigned to them in the Indenture. 

  
 A-7

 ASSIGNMENT FORM 
 To assign this Security, fill in the form below: 
 I or we assign and transfer this Security to:

  
  
 (Insert assignee’s social security or tax I.D. no.) 
  

 
  

 
  

 
  

 
 (Print or type assignee’s name,
address and zip code) 
 and irrevocably appoint
                     as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.

  
  

 

			
	Your Signature:	 	  

		 	(Sign exactly as your name appears on the other side of this Security)

  

			
	Your Name:	 	  

 Date:
                     
  

					
	Signature Guarantee:	 	  
	 	*

  

	*	NOTICE: The Signature must be guaranteed by an Institution which is a member of one of the following recognized signature Guarantee Programs: (i) The Securities
Transfer Agent Medallion Program (STAMP); (ii) The New York Stock Exchange Medallion Program (MNSP); (iii) The Stock Exchange Medallion Program (SEMP); or (iv) such other guarantee program acceptable to the Trustee.

  
 A-8

 SCHEDULE OF EXCHANGES OF INTERESTS IN THE GLOBAL SECURITY 

The following exchanges of an interest in this Global Security for an interest in another Global Security or for a Definitive Security,
or exchanges of an interest in another Global Security or a Definitive Security for an interest in this Global Security have been made: 
  

									
	 Date of Exchange
	 	 Amount of decrease
in Principal Amount of
this Global
Security
	 	 Amount of increase
in Principal Amount of
this Global
Security
	 	 Principal Amount of this
Global Security
following
such decrease or increase
	 	 Signature of authorized
signatory or Trustee
or
Securities Custodian

		 		 		 		 	

  
 A-9

 EXHIBIT B 
 FORM OF GLOBAL 2021 NOTE 
 [FACE OF GLOBAL NOTE] 

THIS GLOBAL NOTE IS HELD BY AND REGISTERED IN THE NAME OF THE DEPOSITORY (AS DEFINED IN THE INDENTURE GOVERNING THIS SECURITY), IS NOT EXCHANGEABLE
FOR SECURITIES REGISTERED IN THE NAME OF A PERSON OTHER THAN THE DEPOSITORY OR ITS NOMINEE EXCEPT IN THE LIMITED CIRCUMSTANCES DESCRIBED IN THE INDENTURE, AND IS NOT TRANSFERABLE TO ANY PERSON UNDER ANY CIRCUMSTANCES EXCEPT THAT (A) THE TRUSTEE
MAY MAKE SUCH NOTATIONS HEREON AS MAY BE REQUIRED PURSUANT TO SECTION 203 OF THE INDENTURE, (B) THIS GLOBAL NOTE MAY BE EXCHANGED PURSUANT TO SECTION 203(1) OF THE INDENTURE, (C) THIS GLOBAL NOTE MAY BE DELIVERED TO THE TRUSTEE FOR
CANCELLATION PURSUANT TO SECTION 309 OF THE INDENTURE AND (D) THIS GLOBAL NOTE MAY BE TRANSFERRED TO A SUCCESSOR DEPOSITORY WITH THE PRIOR WRITTEN CONSENT OF THE COMPANY. 
 UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY TRUST COMPANY, A NEW YORK CORPORATION (“DTC”), TO THE COMPANY OR ITS AGENT FOR REGISTRATION OF TRANSFER,
EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR IN SUCH OTHER NAME AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC (AND ANY PAYMENT IS MADE TO CEDE & CO. OR TO SUCH OTHER ENTITY AS
IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF DTC), ANY TRANSFER, PLEDGE, OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL INASMUCH AS THE REGISTERED OWNER HEREOF, CEDE & CO., HAS AN INTEREST HEREIN.

 CUSIP 98956P AC6 
 ZIMMER HOLDINGS, INC. 
 $300,000,000 3.375% Notes due 2021

  

			
	$300,000,000	 	No.: R-—

 Zimmer Holdings, Inc., a corporation duly organized and existing under the laws of the State of Delaware
(herein called the “Company”, which term includes any successor Person under the Indenture hereinafter referred to), for value received, hereby promises to pay to CEDE & CO., or registered assigns, the principal sum of THREE
HUNDRED MILLION Dollars (or such other lesser or greater amount set forth on the Schedule of Exchanges of Interests in the Global Security attached hereto) on November 30, 2021, and to pay interest thereon from November 10, 2011 or from
the most recent Interest Payment Date to which interest has been paid or duly provided for, semi-annually on May 30 and November 30 each year, commencing 

  
 B-1

 
on May 30, 2012, at the rate of 3.375% per annum, until the principal hereof is paid or made available for payment. The interest so payable, and punctually paid or duly provided for, on
any Interest Payment Date will, as provided in such Indenture, be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on the Regular Record Date for such interest, which shall
be the May 15 or the November 15 (whether or not a Business Day), as the case may be, next preceding such Interest Payment Date. Any such interest not so punctually paid or duly provided for will forthwith cease to be payable to the Holder
on such Regular Record Date and may either be paid to the Person in whose name this Security (or one or more Predecessor Securities) is registered at the close of business on a Special Record Date for the payment of such Defaulted Interest to be
fixed by the Trustee, notice whereof shall be given to Holder of Securities of this series not less than 10 days prior to such Special Record Date, or be paid at any time in any other lawful manner not inconsistent with the requirements of any
securities exchange on which the Securities of this series may be listed, and upon such notice as may be required by such exchange, all as more fully provided in said Indenture. 

Payment of the principal of (and premium, if any) and any such interest on this Security will be made at the office or agency of the
Company maintained for that purpose at the Paying Agent Office of the Trustee, in such coin or currency of the United States of America as at the time of payment is legal tender for payment of public and private debts; provided,
however, that at the option of the Company payment of interest may be made by check mailed to the address of the Person entitled thereto as such address shall appear in the Security Register. 

Reference is hereby made to the further provisions of this Security set forth on the reverse hereof, which further provisions shall for
all purposes have the same effect as if set forth at this place. 
 Unless the certificate of authentication hereon has been
executed by the Trustee referred to on the reverse hereof by manual signature, this Security shall not be entitled to any benefit under the Indenture or be valid or obligatory for any purpose. 

  
 B-2

 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

 

					
	ZIMMER HOLDINGS, INC.
		
	By:	 	  

		 	Name:	 	James T. Crines
		 	Title:	 	Executive Vice President, Finance
		 		 	and Chief Financial Officer

  

			
	Attest:
	
	  

	Name:	 	Heather J. Kidwell
	Title:	 	Senior Corporate Counsel and
		 	Assistant Secretary

  
 B-3

 CERTIFICATE OF AUTHENTICATION 

This is one of the Securities of the series designated therein referred to in the within-mentioned Indenture. 

Dated: November 10, 2011 
  

			
	Wells Fargo Bank, National Association
	 as Trustee

		
	By:	 	  

		 	Authorized Signatory

  
 B-4

 [FORM OF REVERSE OF NOTE] 

This Security is one of a duly authorized issue of securities of the Company (herein called the “Securities”), issued and to be
issued in one or more series under an Indenture, dated as of November 17, 2009 (herein called the “Indenture”, which term shall have the meaning assigned to it in such instrument), between the Company and Wells Fargo Bank, National
Association, as Trustee (herein called the “Trustee”, which term includes any successor trustee under the Indenture), and reference is hereby made to the Indenture for a statement of the respective rights, limitations of rights, duties and
immunities thereunder of the Company, the Trustee and the Holders of the Securities and of the terms upon which the Securities are, and are to be, authenticated and delivered. This Security is one of the series designated on the face hereof, limited
in aggregate principal amount to $300,000,000. 
 The Securities of this series are subject to redemption at any time, upon not
less than 30 days’ and not more than 60 days’ notice by mail, as a whole or from time to time in part, at the election of the Company (provided, however, that, if the Company shall have elected pursuant to the Indenture to
defease the entire Indebtedness of this Security or certain restrictive covenants and Events of Defaults with respect to this Security, prior to making such election to redeem the Securities it shall have deposited in trust amounts sufficient to pay
the redemption price), at any time prior to August 30, 2021 (three months prior to their Stated Maturity) at a redemption price equal to the greater of (i) 100% of the principal amount of such Securities to be redeemed, plus accrued and
unpaid interest thereon to the Redemption Date and (ii) the sum of the present values of the Remaining Scheduled Payments (as defined below) of such Securities to be redeemed, discounted to the Redemption Date on a semi-annual basis (assuming a
360-day year consisting of twelve 30-day months) at the Treasury Rate (as defined below), plus 20 basis points, plus accrued and unpaid interest thereon to the Redemption Date. 

The Securities of this series are subject to redemption at any time, upon not less than 30 days’ and not more than 60 days’
notice by mail, as a whole or from time to time in part, at the election of the Company (provided, however, that, if the Company shall have elected pursuant to the Indenture to defease the entire Indebtedness of this Security or
certain restrictive covenants and Events of Defaults with respect to this Security, prior to making such election to redeem the Securities it shall have deposited in trust amounts sufficient to pay the redemption price), at any time on or after
August 30, 2021 (three months prior to their Stated Maturity) at a redemption price equal to 100% of the principal amount of such Securities to be redeemed, plus accrued and unpaid interest thereon to the Redemption Date. 

“Treasury Rate” means, with respect to any Redemption Date, the rate per annum equal to the semi-annual equivalent yield
to maturity of the Comparable Treasury Issue, assuming a price for the Comparable Treasury Issue (expressed as a percentage of its principal amount) equal to the Comparable Treasury Price for such Redemption Date. 

“Comparable Treasury Issue” means the United States Treasury security selected by the Quotation Agent as having a
maturity comparable to the remaining term of the series of Securities to be redeemed that would be utilized, at the time of selection and in accordance with 

  
 B-5

 
customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining term of such Securities. 

“Comparable Treasury Price” means, with respect to any Redemption Date, (1) the average of four Reference Treasury
Dealer Quotations for such Redemption Date, after excluding the highest and lowest such Reference Treasury Dealer Quotations, (2) if the Company can only obtain less than four such Reference Treasury Dealer Quotations, the average of all such
quotations or (3) if the Company can only obtain one Reference Treasury Dealer Quotation, such quotation. 

“Quotation Agent” means the Reference Treasury Dealer appointed by the Company. 

“Reference Treasury Dealer” means (1) each of BNP Paribas Securities Corp., Merrill Lynch, Pierce,
Fenner & Smith Incorporated and RBS Securities Inc. (or their respective affiliates that are Primary Treasury Dealers) and their respective successors; provided, however, that if any of the foregoing shall cease to be a
primary U.S. Government securities dealer in New York City (a “Primary Treasury Dealer”), the Company will substitute therefor another Primary Treasury Dealer, and (2) another Primary Treasury Dealer selected by the Company.

 “Reference Treasury Dealer Quotations” means, with respect to each Reference Treasury Dealer and any
Redemption Date, the average, as determined by the Company, of the bid and asked prices for the Comparable Treasury Issue (expressed in each case as a percentage of its principal amount) quoted in writing to the Company by such Reference Treasury
Dealer at 5:00 p.m., New York City time, on the third Business Day preceding such Redemption Date. 
 “Remaining
Scheduled Payments” means, with respect to each Security to be redeemed, the remaining scheduled payments of the principal thereof and interest thereon that would be due after the related Redemption Date for such redemption;
provided, however, that, if such Redemption Date is not an Interest Payment Date with respect to such Security, the amount of the next succeeding scheduled interest payment thereon will be reduced by the amount of interest accrued
thereon to such Redemption Date. 
 In the event of redemption of this Security in part only, a new Security or Securities of
this series and of like tenor for the unredeemed portion hereof will be issued in the name of the Holder hereof upon the cancellation hereof. 
 If a Change of Control Repurchase Event occurs, unless the Company has exercised its right to redeem the Securities of this series pursuant to the Indenture, the Company will be required to make an offer
to each Holder of the Securities of this series to repurchase all or any part (in minimum denominations of $2,000 and integral multiples of $1,000 above that amount) of that Holder’s Securities of this series at a repurchase price in cash equal
to 101% of the aggregate principal amount of such Securities repurchased plus any accrued and unpaid interest on such Securities repurchased to the date of repurchase, in accordance with and pursuant to the terms and conditions set forth in the
Indenture. 
 The Indenture contains provisions for defeasance at any time of the entire Indebtedness of this Security or
certain restrictive covenants and Events of Default with respect to this Security, in each case upon compliance with certain conditions set forth in the Indenture. 

  
 B-6

 If an Event of Default with respect to Securities of this series shall occur and be
continuing, the principal of the Securities of this series may be declared due and payable in the manner and with the effect provided in the Indenture. 
 The Indenture permits, with certain exceptions as therein provided, the amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities
of each series to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a majority in principal amount of the Securities at the time Outstanding of each series to be affected. The Indenture
also contains provisions permitting the Holders of specified percentages in principal amount of the Securities of each series at the time Outstanding, on behalf of the Holders of all Securities of such series, to waive compliance by the Company with
certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be conclusive and binding upon such Holder and upon all future Holders of this
Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is made upon this Security. 

As provided in and subject to the provisions of the Indenture, the Holder of this Security shall not have the right to institute any
proceeding with respect to the Indenture or for the appointment of a receiver or trustee or for any other remedy thereunder, unless such Holder shall have previously given the Trustee written notice of a continuing Event of Default with respect to
the Securities of this series, the Holders of not less than 25% in principal amount of the Securities of this series at the time Outstanding shall have made written request to the Trustee to institute proceedings in respect of such Event of Default
as Trustee and offered the Trustee indemnity or security reasonably satisfactory to it, and the Trustee shall not have received from the Holders of a majority in principal amount of Securities of this series at the time Outstanding a direction
inconsistent with such request, and shall have failed to institute any such proceeding, for 60 days after receipt of such notice, request and offer of indemnity. The foregoing shall not apply to any suit instituted by the Holder of this Security for
the enforcement of any payment of principal hereof or any premium or interest hereon on or after the respective due dates expressed herein. 
 No reference herein to the Indenture and no provision of this Security or of the Indenture shall alter or impair the obligation of the Company, which is absolute and unconditional, to pay the principal of
and any premium and interest on this Security at the times, place and rate, and in the coin or currency, herein prescribed. 

As provided in the Indenture and subject to certain limitations therein set forth, the transfer of this Security may be registered and
this Security may be exchanged as provided in the Indenture. 
 The Securities of this series are issuable only in registered
form without coupons in minimum denominations of $2,000 and any integral multiple of $1,000 in excess thereof. 
 No service
charge shall be made for any such registration of transfer or exchange, but the Company may require payment of a sum sufficient to cover any tax or other governmental 

  
 B-7

 
charge payable in connection therewith. 
 Prior to due presentment of
this Security for registration of transfer, the Company, the Trustee and any agent of the Company or the Trustee may treat the Person in whose name this Security is registered as the owner hereof for all purposes, whether or not this Security be
overdue, and neither the Company, the Trustee nor any such agent shall be affected by notice to the contrary. 
 All terms used
in this Security which are defined in the Indenture shall have the meanings assigned to them in the Indenture. 
 ASSIGNMENT
FORM 
 To assign this Security, fill in the form below: 
 I or we assign and transfer this Security to: 
  

 
 (Insert assignee’s social
security or tax I.D. no.) 
  
  

 
  
  

 
  

 
 (Print or type assignee’s name,
address and zip code) 
 and irrevocably appoint
                     as agent to transfer this Security on the books of the Company. The agent may substitute another to act for him.

  
  

 

			
	Your Signature:	 	  

		 	(Sign exactly as your name appears on the other side of this Security)

  

			
	Your Name:	 	  

 Date:
                     
  

			
	Signature Guarantee:	 	  

  

	*	NOTICE: The Signature must be guaranteed by an Institution which is a member of one of the following recognized signature Guarantee Programs: (i) The Securities
Transfer Agent Medallion Program (STAMP); (ii) The New York Stock Exchange Medallion Program (MNSP); (iii) The Stock Exchange Medallion Program (SEMP); or (iv) such other guarantee program acceptable to the Trustee.

  
 B-8

 SCHEDULE OF EXCHANGES OF INTERESTS IN THE GLOBAL SECURITY 

The following exchanges of an interest in this Global Security for an interest in another Global Security or for a Definitive Security,
or exchanges of an interest in another Global Security or a Definitive Security for an interest in this Global Security have been made: 
  

									
	 Date of Exchange
	 	 Amount of decrease
in Principal Amount of
this Global
Security
	 	 Amount of increase
in Principal Amount of
this Global
Security
	 	 Principal Amount of this
Global Security
following
such decrease or increase
	 	 Signature of authorized
signatory or Trustee
or
Securities Custodian

		 		 		 		 	

  
 B-9

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00196-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00196-of-00352.parquet"}]]