Document:

<PAGE>

                                                                   EXHIBIT 10.38

                                  July 18, 2006

Mr. Paul Sagan
[address]

      Re: Amendment to Employment Agreement

Dear Paul:

      In accordance with Section 9 of your January 4, 2005 Employment Agreement
with Akamai Technologies, Inc. (the "Company"), the following sets forth an
amendment thereto.

     Section 5, second  paragraph,  is hereby amended in its entirety to read as
follows:

            5. Termination of Employment.

            If you terminate your employment for "Good Reason" following a
   "Change of Control" as those terms are defined in the Initial Option
   Agreement and any Additional Option Agreement (together, the "Option
   Agreements"), in addition to any rights you have under the Option Agreements,
   vesting of all outstanding unvested options held by you as of the termination
   date shall automatically accelerate in full. You shall also be entitled to
   lump sum cash payments equal to: two (2) years of your then-current
   annualized base salary and an award equal to two (2) times your
   then-applicable annual incentive bonus at target. For purposes of this
   paragraph 5, "bonus at target" shall be as set forth in the terms of the
   then-applicable annual incentive bonus plan. Provisions in restricted stock
   unit agreements you have entered into with the Company that relate to the
   effect of a termination of employment are not amended by this Section 5 and
   shall continue in effect.

      Except as set forth herein, the terms of the Employment Agreement, as
previously amended, remain in full force and effect, without amendment. Please
sign below to indicate your acceptance of the terms of this amendment to your
Employment Agreement.

                            Very truly yours,

                            AKAMAI TECHNOLOGIES, INC.

                            By:  /s/ George H. Conrades
                                 -------------------------------------------
                                 George H. Conrades, Executive Chairman

      I accept the foregoing amendment to my Employment Agreement with the
Company.

                            /s/ Paul Sagan
                            ------------------------------------------------
                            Paul Sagan

                            Date:  August 9, 2006<PAGE>

                                                                   EXHIBIT 10.39

                            AKAMAI TECHNOLOGIES, INC.

      POLICY ON DIRECTOR COMPENSATION PAYABLE UPON DEPARTURE FROM THE BOARD

                           Adopted September 20, 2006

      Upon the departure from the Board of Directors of a non-employee Director
who is in good standing at the time of his or her departure(1), such Director
shall be entitled to the cash payments and accelerated vesting of equity awards
as set forth below:

Annual Cash Retainer

The Director will receive a cash payment equal to the annual cash retainer
payable to the Director under Akamai's non-employee director compensation plan
pro-rated based on the number of months lapsed since the most recent annual
meeting of the company's stockholders.

Equity Compensation Vesting

If the Director has completed one year of Board service at the time of
departure, 100% of the unvested deferred stock units (or similar full-value
equity awards granted to him or her) held by the Director shall vest as of the
time of departure and become distributable in accordance with their terms or the
Director's prior election.

If the Director has completed three years of Board service at the time of
departure, 100% of the unvested options initially granted to such Director upon
joining the Board shall vest as of the time of departure and become exercisable
in full.

-----------------

(1)   A Director shall be considered to be in good standing unless a majority of
      the Board of Directors otherwise so determines on or about the time of
      such Director's departure.<PAGE>
                                                                     Exhibit 4.1

016570| 003590|127C|RESTRICTED||4|057-423

 COMMON STOCK                                           COMMON STOCK

PAR VALUE $0.01                              THIS CERTIFICATE IS TRANSFERABLE IN
                                               CANTON, MA, OR JERSEY CITY, NJ

<TABLE>
<S>           <C>                                                    <C>
CERTIFICATE
   NUMBER                                                                SHARES
ZQ 000412                     EPIX Pharmaceuticals                   **600620******
              INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE   ***600620*****
                                                                     ****600620****
                                                                     *****600620***
                                                                     ******600620**
</TABLE>

THIS CERTIFIES THAT   MR. SAMPLE & MRS. SAMPLE &   CUSIP 26881Q 30 9
                      MR. SAMPLE & MRS. SAMPLE     SEE REVERSE FOR CERTAIN
                                                   DEFINITIONS

is the owner of       *** SIX HUNDRED THOUSAND
                      SIX HUNDRED AND TWENTY***

            FULLY PAID AND NONASSESSABLE SHARES OF THE COMMON STOCK,
                          PAR VALUE $0.01 PER SHARE, OF

EPIX PHARMACEUTICALS, INC. (THE "CORPORATION"), transferable on the books of the
Corporation in person or by duly authorized attorney upon surrender of this
Certificate properly endorsed or assigned. This Certificate and the shares
represented hereby are issued and held subject to laws of the State of Delaware
and to the provisions of the Certificate of Incorporation and By-Laws of the
Corporation, each as now in effect or hereafter amended. This Certificate is not
valid unless countersigned and registered by the Transfer Agent and Registrar.

IN WITNESS WHEREOF, the Corporation has caused this Certificate to be executed
by the facsimile signatures of its duly authorized officers and sealed with the
facsimile seal of the Corporation.

<TABLE>
<S>                                     <C>                     <C>
                                            (SEAL OF EPIX       DATED <<Month Day, Year>>
                                        PHARMACEUTICALS INC.)
/s/ Illegible                            (CORPORATE DELAWARE    COUNTERSIGNED AND REGISTERED:
-------------------------------------           1988)           COMPUTERSHARE TRUST COMPANY, N.A.
President                                                       TRANSFER AGENT AND REGISTRAR,

/s/ Illegible                                                   By
-------------------------------------                              -------------------------------------
Treasurer and Chief Financial Officer                              AUTHORIZED SIGNATURE
</TABLE>

                        SECURITY INSTRUCTIONS ON REVERSE

<TABLE>
<S>                                        <C>                     <C>
                                           CUSIP                                XXXXXX XX X
                                           HOLDER ID                             XXXXXXXXXX
EPIX Pharmaceuticals                       INSURANCE VALUE                     1,000,000.00
                                           NUMBER OF SHARES                          123456
PO BOX 43004, PROVIDENCE, RI 02940-3004    DTC                     12345678 123456789012345
</TABLE>

<TABLE>
<CAPTION>
                                           CERTIFICATE NUMBERS     NUM/NO.   DENOM.   TOTAL
                                           -------------------     -------   ------   -----
<S>                                        <C>                     <C>       <C>      <C>
MR A SAMPLE                                1234567890/1234567890      1         1       1
DESIGNATION (IF ANY)                       1234567890/1234567890      2         2       2
ADD 1                                      1234567890/1234567890      3         3       3
ADD 2                                      1234567890/1234567890      4         4       4
ADD 3                                      1234567890/1234567890      5         5       5
ADD 4                                      1234567890/1234567890      6         6       6
                                           TOTAL TRANSACTION                            7
</TABLE>
<PAGE>

<TABLE>
<S>                                                     <C>
EPIX PHARMACEUTICALS, INC.

THE CORPORATION IS AUTHORIZED TO ISSUE MORE THAN ONE CLASS AND SERIES OF STOCK. THE CORPORATION WILL FURNISH TO THE HOLDER UPON
WRITTEN REQUEST WITHOUT CHARGE A STATEMENT OF THE POWERS, DESIGNATIONS, PREFERENCES AND RELATIVE, PARTICIPATING, OPTIONAL OR OTHER
SPECIAL RIGHTS OF EACH CLASS OF STOCK OR SERIES THEREOF AND THE QUALIFICATIONS, LIMITATIONS OR RESTRICTIONS OF SUCH PREFERENCES
AND/OR RIGHTS.

The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were
written out in full according to applicable laws or regulations:

TEN COM - as tenants in common                          UNIF GIFT MIN ACT -            Custodian
                                                                            ----------           ----------
                                                                              (Cust)               (Minor)
TEN ENT - as tenants by the entireties                                 under Uniform Gifts to Minors Act
                                                                                                         ----------
                                                                                                           (State)
JT TEN  - as joint tenants with right of survivorship   UNIF TRF MIN ACT                     Custodian (until age      )
          and not as tenants in common                                   --------------------                     -----  ----------
                                                                                (Cust)                                     (Minor)
                                                                       under Uniform Transfers to Minors Act
                                                                                                             ----------
                                                                                                               (State)
          Additional abbreviations may also be used though not in the above list.

                                                              PLEASE INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE

                                                              ---------------------------------------------------------------------
For value received,                             hereby sell, assign and transfer unto
                    ----------------------------

-----------------------------------------------------------------------------------------------------------------------------------
(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING POSTAL ZIP CODE, OF ASSIGNEE)

-----------------------------------------------------------------------------------------------------------------------------------

-----------------------------------------------------------------------------------------------------------------------------------
                                                                                                                             Shares
----------------------------------------------------------------------------------------------------------------------------
of the common stock represented by the within Certificate, and do hereby irrevocably constitute and appoint
                                                                                                                           Attorney
--------------------------------------------------------------------------------------------------------------------------
to transfer the said stock on the books of the within named Corporation with full power of substitution in the premises.

Dated:                                           20                           Signature(s) Guaranteed: Medallion Guarantee Stamp
       ------------------------------------------  --------------------    THE SIGNATURE(S) MUST BE GUARANTEED BY AN ELIGIBLE
                                                                           GUARANTOR INSTITUTION (Banks, Stockbrokers, Savings and
                                                                           Loan Associations and Credit Unions) WITH MEMBERSHIP IN
Signature:                                                                 AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM,
           ------------------------------------------------------------    PURSUANT TO S.E.C. RULE 17Ad-15.

Signature:
           ------------------------------------------------------------
           Notice: The signature to this assignment must correspond with
                   the name as written upon the face of the certificate,
                   in every particular, without alteration or
                   enlargement, or any change whatever.
</TABLE>

SECURITY INSTRUCTIONS
THIS IS WATERMARKED PAPER, DO NOT EXCEPT WITHOUT NOTING
WATERMARK HOLD TO LIGHT TO VERIFY WATERMARK

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