Document:

EX-10.8

 Exhibit 10.8 
  

			
	

	  	  
 1035 O’Brien Drive, Menlo Park, CA 9025

Tel +1-650-735-1324 | Fax +1-650-362-1908

 April 2, 2014 
 Linda C.
Bain 
 [ADDRESS] 
 [ADDRESS] 

Re: Employment Terms For Chief Financial Officer 
 Dear
Linda: 
 We are excited to offer you a position with Avalanche as Chief Financial Officer. We hope that you will decide to join our growing team of
scientists and biotechnology professionals. Our mission is to bring new medicines to patients suffering from blinding diseases, and we think you can play a key role in helping make our vision a reality. 

This letter agreement (the “Agreement”) memorializes the employment terms for your anticipated hire by Avalanche Biotechnologies, Inc. (the
“Company”) in the position of Chief Financial Officer. These terms will become effective as of April 14, 2014 (as applicable, the “Hire Date”). 

Effective as of the Hire Date, your employment terms will be as follows: 
  

	1.	Duties; Reporting Relationship; Office Location. 

 In the position of Chief Financial Officer, you will
serve as the top finance official in the company, and will be required to perform the duties commonly associated with this position. These duties include providing financial leadership and management of the finance team, managing external
relationships with investors, analysts and the financial community, leading internal finance operations, including accounting and financial reporting, financial planning and analysis, compliance with external auditors and applicable regulations, and
serving as a key member of the company’s senior leadership team, as well as other activities that may be assigned to you by the Company’s Chief Executive Officer (the “CEO”) from time to time. You will report to the CEO, and will
work at the Company’s headquarters at 1035 O’Brien Drive, Menlo Park, CA 94025. 
  

	2.	Compensation and Benefits. 

 Your base salary will be $280,000 per annum, subject to payroll deductions
and all required withholdings, representing full-time employment with the Company. Your salary will be paid in accordance with the Company’s standard payroll schedule. 

In addition, you will be eligible to earn an annual performance bonus with a target bonus amount equal to twenty-five percent (25%) (“Target
Percentage”) of your 

			
	

	  	  
 1035 O’Brien Drive, Menlo Park, CA 9025

Tel +1-650-735-1324 | Fax +1-650-362-1908

  

 
salary earned during the bonus year, provided that you are actively employed as CFO from the Hire Date through and including the date of bonus grants. Your annual bonus will be based on the
Target Percentage, and will be adjusted upward or downward based on attainment of milestone objectives (including corporate and personal objectives) to be determined by the Board each year, and you must remain employed through the entire bonus year
to earn a performance bonus. Bonus payments may be in the form of cash and/or incentive stock options, and will be granted entirely at the discretion of the Company’s CEO and Board of Directors. Any cash bonus payments will be less payroll
deductions and all required withholdings. 
 You will be eligible to participate in the Company’s general employee benefits, including the executive
severance benefit plan, in accordance with the terms, conditions and limitations of the benefit plans to the extent such plans have been established by the Company. As CFO, the executive severance benefit plan will include eligibility for severance
pay, in the cases of involuntary termination without cause or voluntary termination for good cause. Such a plan would be comparable to similar private companies at similar stages of development, and would be approved by the Company’s Board of
Directors within six (6) months of the Hire Date. 
 You will also be eligible for executive relocation assistance, provided that you work through
the Company’s preferred relocation services providers. The Company will provide household goods move including up to thirty days storage (not to exceed $40,000) and up to 60 days temporary housing, selected and approved by Company, grossed
up for applicable taxes. You will also receive a miscellaneous relocation allowance of $3,000, which will not be grossed up for taxes, to be used toward any other miscellaneous items. Should you terminate your employment or be terminated for cause
within twelve (12) months, you will be responsible for repaying 100% of the cash value of relocation assistance. 
  

	3.	Incentive Stock Option grant. 

 In addition to the compensation and benefits described above, the Company
will grant you, subject to the approval of the Company’s board of directors and the Company successfully obtaining a permit from the applicable state authority, the option to purchase two hundred forty thousand (240,000) shares of the
Company’s common stock, at the fair market value as determined by the Company’s board of directors at the date of the grant. The foregoing stock option will be subject to the Company’s 2006 Equity Incentive Plan and standard form of
stock option agreement (the “Option Agreement”), and shall provide that 25% of the shares vest after twelve (12) months, and the remaining 75% of the shares vest in equal monthly installments over the following thirty-six
(36) months. 

			
	

	  	  
 1035 O’Brien Drive, Menlo Park, CA 9025

Tel +1-650-735-1324 | Fax +1-650-362-1908

  

	4.	Confidentiality and Proprietary Information Obligations. 

  

	 	(a)	Company Policies and Proprietary Information Agreement: You will be required to sign the Employee Proprietary Information and Inventions Assignment Agreement attached hereto as Exhibit A (the “Proprietary
Information Agreement”). 

  

	 	(b)	Adverse or Outside Business Activities. Throughout your employment with the Company, you may engage in civic, academic teaching and lectures, and not-for-profit activities so long as such activities do not interfere
with the performance of your duties hereunder or present a conflict of interest with the Company. You may not engage in other employment or undertake any other commercial business activities unless you obtain the prior written consent of the
Company’s CEO. The Company may rescind its consent to your service as a director of all other corporations or participation in other business or public activities, if the Company, in its sole discretion, determines that such activities
compromise or threaten to compromise the Company’s reputational or business interests or conflict with your duties to the Company. In addition, throughout the term of your employment with the Company, you agree not to, directly or indirectly,
without the prior written consent of the Company, own, manage, operate, join, control, finance or participate in the ownership, management, operation, control or financing of, or be connected as an officer, director, executive, partner, employee,
principal, agent, representative, consultant, licensor, licensee or otherwise with, any business or enterprise engaged in any business which is competitive with or which is reasonably anticipated to be competitive with the Company’s business;
provided, however, that you may purchase or otherwise acquire up to (but not more than) one percent (1%) of any class of securities of any enterprise (but without participating in the activities of such enterprise) if such securities are listed
on any national or regional securities exchange. You hereby represent and warrant that you have disclosed previously to the Board all other employment or other commercial business activities that you already undertake, or intend to undertake (to the
extent currently known by you), during your period of employment with the Company. 

  

	5.	No Conflicts. 

 By signing this Agreement you hereby represent to the Company that, except as previously
disclosed to the Company: (a) your employment with the Company is not prohibited under any employment agreement or other contractual arrangement; and (b) you do not know of any conflicts which would restrict your employment with the
Company. You hereby represent that you have disclosed to the Company any contract you have signed that may restrict your activities on behalf of the Company, and that you are presently in compliance with such contracts, if any. 

			
	

	  	  
 1035 O’Brien Drive, Menlo Park, CA 9025

Tel +1-650-735-1324 | Fax +1-650-362-1908

  

	6.	At Will Employment. 

 Your employment relationship with the Company will be an “at-will”
arrangement and this Agreement does not constitute a guarantee of employment for any specific period of time. This means that either you or the Company may terminate your employment at any time, with or without cause, and with or without advance
notice. This “at-will” employment relationship cannot be changed except in a written agreement approved by the Company and signed by you and by a duly authorized officer of the Company. 

 

	7.	Miscellaneous. 

 As required by law, your employment is contingent upon satisfactory proof of your
identity and legal authorization to work in the United States. This Agreement, together with your Proprietary Information Agreement, forms the complete and exclusive statement of your employment agreement with the Company. The employment terms in
this Agreement supersede any other agreements or promises made to you by anyone, whether oral or written, concerning your employment terms. Changes in your employment terms, other than those changes expressly reserved to the Company’s or
Board’s discretion in this Agreement, require a written modification approved by the Board and signed by you and a duly authorized member of the Board. This Agreement will bind the heirs, personal representatives, successors and assigns of both
you and the Company, and inure to the benefit of both you and the Company, their heirs, successors and assigns. If any provision of this Agreement is determined to be invalid or unenforceable, in whole or in part, this determination shall not affect
any other provision of this Agreement and the provision in question shall be modified so as to be rendered enforceable in a manner consistent with the intent of the parties insofar as possible under applicable law. This Agreement shall be construed
and enforced in accordance with the laws of the State of California without regard to conflicts of law principles. Any ambiguity in this Agreement shall not be construed against either party as the drafter. Any waiver of a breach of this Agreement,
or rights hereunder, shall be in writing and shall not be deemed to be a waiver of any successive breach or rights hereunder. This Agreement may be executed in counterparts which shall be deemed to be part of one original, and facsimile signatures
shall be equivalent to original signatures. 

			
	

	  	  
 1035 O’Brien Drive, Menlo Park, CA 9025

Tel +1-650-735-1324 | Fax +1-650-362-1908

  

 Please sign and date this letter and return it to me by the close of business on April 4, 2014 in
order to confirm your anticipated employment terms as set forth above. 
 We look forward to a productive and enjoyable work relationship with you. 

 

	
	 Sincerely,

	Avalanche Biotechnologies, Inc.:
	
	 /s/ Tom Chalberg

	
	 Thomas W. Chalberg, President and Chief Executive Officer

	
	
	Understood and Accepted:
	
	 /s/ Linda C. Bain

	 Linda C. Bain

	
	 Date: 4/6/14

			
	

	  	  
 1035 O’Brien Drive, Menlo Park, CA 9025

Tel +1-650-735-1324 | Fax +1-650-362-1908

  

 EXHIBIT A 

EMPLOYEE PROPRIETARY INFORMATION AND INVENTIONS ASSIGNMENT 

AGREEMENT 

 Avalanche Biotechnologies, Inc. 

EMPLOYEE CONFIDENTIALITY AND INVENTIONS ASSIGNMENT AGREEMENT 

In partial consideration and as a condition of my employment by AVALANCHE BIOTECHNOLOGIES, (the
“Company”), and effective as of the date that my employment by the Company first commenced as set forth below, I, the undersigned, agree as follows: 

1. NONDISCLOSURE OF CONFIDENTIAL INFORMATION. 

1.1 Confidential Information. During the term of my employment, I may receive and otherwise be exposed to confidential and proprietary
information relating to the Company’s business, strategies, designs and technologies, or to proprietary or confidential information relating to the Company’s suppliers, customers or business partners. Such confidential and proprietary
information may include but not be limited to confidential or proprietary information supplied to me with the legend “Confidential” or “Proprietary,” or equivalent, and any of the following types of information, whether or not
marked as confidential or proprietary: (i) information regarding physical or chemical or biological materials (such as, but not limited to, reagents, gene sequences, nucleic acids, cell lines, media, antibodies, compounds, c-DNAs, antisense
nucleotides, proteins and vectors) and techniques for their handling and use; (ii) information regarding ideas, technology and processes (such as, but not limited to, assays, techniques, sketches, schematics, drawings, works of authorship,
models, designs, inventions, know-how, technical documentation, equipment, algorithms, software programs, software source documents, formulae); (iii) information concerning or resulting from research and development projects and other projects
(such as, but not limited to, preclinical and clinical data, design details and specifications, engineering information, and works in process); (iv) business and financial information (such as, but not limited to, current, future, and proposed
products and services, financial information and models, information relating to procurement requirements, purchasing, manufacturing, customer lists, product plans, product ideas, business strategies, marketing or business plans, financial or
personnel matters, investors, employees, business and contractual relationships, business forecasts, sales and merchandising, and information regarding third parties, suppliers, customers, employees, investors or facilities); (v) Inventions (as
defined below), and (iv) information, derivatives, improvements or enhancements created using the foregoing information. (all of the above collectively referred to as “Confidential Information”). I understand that Confidential
Information shall not include information that (a) is in the public domain at the time of disclosure or enters the public domain following disclosure through no fault of mine, (b) is already in my possession prior to disclosure hereunder
(as reflected by my written records), or (c) is required to be disclosed pursuant to an order of any competent court or government agency or rules of a securities exchange. 

1.2 Duties. I acknowledge the confidential and secret character of the Confidential Information, and agree that the Confidential
Information is the sole, exclusive and extremely valuable property of Company. Accordingly, I agree not to use the Confidential Information except in the performance of my authorized duties as an employee of Company, and not to disclose all or any
part of the Confidential Information in any form to any third party, either during or after the term of my employment, without the prior written consent of the Company on a case-by-case basis. Appropriate prior written consent will be determined as
follows: (i) if I am not an executive officer of the Company, then consent may be obtained from an executive officer of the Company, or (ii) if I am an executive officer of the Company, then from the Board of Directors of the Company. Upon
termination of my employment, I agree to cease using and to return to Company all whole and partial copies and derivatives of the Confidential Information, whether in my possession or under my direct or indirect control, provided that I am entitled
to retain my personal copies of (i) my compensation records, (ii) materials distributed to shareholders generally and (iii) this Agreement. 

  
 1 

 2. PROPERTY OF THE COMPANY. All
notes, memoranda, reports, drawings, blueprints, manuals, materials, data, emails and other papers and records of every kind which shall come into my possession at any time after the commencement of my employment with the Company, relating to any
Inventions (as defined below) or Confidential Information, shall be the sole and exclusive property of the Company. This property shall be surrendered to the Company upon termination of my employment with the Company, or upon request by the Company,
at any other time either during or after the termination of such employment. I further agree that in the event of termination of my employment with the Company I will execute a Termination Certificate substantially in the form attached hereto as
Exhibit A. 
 3. INVENTIONS. 

3.1 Disclosure. I shall disclose promptly in writing to an officer or to attorneys of the Company in accordance with the Company’s
policies and procedures any idea, invention, work of authorship, whether patentable or unpatentable, copyrightable or uncopyrightable, including, but not limited to, any documentation, formula, design, device, code, improvement, method, process,
discovery, concept, development, machine or contribution, techniques, formulas, formulations, data, programs, organisms, plasmids, cosmids, bacteriophages, expression vectors, cells, cell lines, tissues, materials, substrates, media, delivery
methods or transfection methods, assays, compounds, peptides, proteins, DNA, RNA, and their constructs, and sequence, genomic, and structural information relating thereto, crystals, optically active materials, ceramics, metals, metal oxides, and
organic and inorganic chemical, biological and other material and their progeny, clones and derivatives and salt forms (any of the foregoing items hereinafter referred to as an “Invention”) I may conceive, make, develop or work on,
in whole or in part, solely or jointly with others, during the term of my employment with the Company. The disclosure required by this Section applies (a) during the period of my employment with the Company and for one year thereafter;
(b) with respect to all Inventions whether or not they are conceived, made, developed or worked on by me during my regular hours of employment with the Company; (c) whether or not the Invention was made at the suggestion of the Company;
(d) whether or not the Invention was reduced to drawings, written description, documentation, models or other tangible form; and (e) whether or not the Invention is related to the general line of business engaged in by the Company. The
Company agrees that it will take reasonable precautions to keep Inventions disclosed to it pursuant to this Section 3.1 in confidence and shall not use any Inventions for its own advantage unless those Inventions are assigned or assignable to
the Company pursuant to Section 3.2 or otherwise. 
 3.2 Assignment of Inventions to Company; Exemption of Certain Inventions. I
hereby assign to the Company, and agree to assign automatically without requirement of further writing when first reduced to practice or recorded in a tangible medium, without royalty or any other further consideration, my entire right, title and
interest in and to all Inventions and all intellectual property rights therein that (i) relate to the subject matters related to my employment and exist as of the date of this Agreement, for which I do not have an obligation to assign to any
third party or (ii) I conceive, make, develop or work on during the period of my employment with the Company and for one year thereafter, except those Inventions that I develop entirely on my own time after the date of this Agreement without
using the Company’s equipment, supplies, facilities or Confidential Information, unless those Inventions either (a) relate at the time of conception or reduction to practice of the Invention to the Company’s business, or actual or
demonstrably anticipated research or development of the Company; or (b) result from or are related to any work performed by me for the Company, in which case I agree that any such Inventions shall also be automatically assigned to the Company.
I acknowledge and agree that the Company has hereby notified me that the assignment provided for in Section 3.2(ii) does not apply to any Invention which qualifies fully for exemption from assignment under the provisions of Section 2870 of
the California Labor Code, a copy of which is attached as Exhibit B. I also acknowledge and agree that nothing in this Section 3.2 above limits the assignment of any other rights in or to Confidential Information or other technology or
intellectual property of the Company other than Inventions. 

  
 2 

 3.3 Records. I will make and maintain adequate and current written records of all
Inventions covered by Section 3.1. These records shall be and remain the property of the Company. 
 3.4 Patents and Other
Rights. Subject to Section 3.2, I will assist the Company in obtaining, maintaining and enforcing patents, invention assignments and copyright assignments, and other proprietary rights in connection with any Invention covered by
Section 3.1, and otherwise will assist the Company as reasonably required by the Company to perfect in the Company the rights, title and other interests in my work product granted to the Company under this Agreement. Reasonable costs related to
such assistance, if required, will be paid by the Company. I further agree that my obligations under this Section 3.4 shall continue beyond the termination of my employment with the Company, but if I am called upon to render such assistance
after the termination of such employment, I shall be entitled to a fair and reasonable rate of compensation for such assistance. I shall, in addition, be entitled to reimbursement of any expenses incurred at the request of the Company relating to
such assistance after the term of my employment. I hereby agree to waive any moral rights I may have in any copyrightable work I create on behalf of the Company. If the Company is unable for any reason, after reasonable effort, to secure my
signature on any document needed in connection with the actions specified above, I hereby irrevocably designate and appoint the Company and its duly authorized officers and agents as my agent and attorney in fact, which appointment is coupled with
an interest, to act for and in my behalf to execute, verify and file any such documents and to do all other lawfully permitted acts to further the purposes of this Section 3.4 with the same legal force and effect as if executed by me. 

3.5 Prior Contracts and Inventions; Information Belonging to Third Parties. I represent and warrant that, except as set forth on
Exhibit C hereto, there are no other contracts to assign Inventions that are now in existence between any other person or entity and me. I further represent that (a) I am not obligated under any consulting, employment or other agreement which
would affect the Company’s rights or my duties under this Agreement, (b) there is no action, investigation, or proceeding pending or threatened, or any basis therefor known to me involving my prior employment or any consultancy or the use
of any information or techniques alleged to be proprietary to any former employer, and (c) the performance of my duties as an employee of the Company will not breach, or constitute a default under any agreement to which I am bound, including,
without limitation, any agreement limiting the use or disclosure of proprietary information acquired in confidence prior to engagement by the Company. I will not, in connection with my employment by the Company, use or disclose to the Company any
confidential, trade secret or other proprietary information of any previous employer or other person to which I am not lawfully entitled. As a matter of record, I attach as Exhibit C of this Agreement a brief description of all Inventions made or
conceived by me prior to my employment with the Company which I desire to be excluded from this Agreement (“Background Technology”). I hereby grant Company a non-exclusive, royalty-free, perpetual and irrevocable, worldwide right to
use and sublicense the use of Background Technology for the purpose of developing, marketing, selling and supporting Company technology, products and services, either directly or through multiple tiers of distribution, but not for the purpose of
marketing Background Technology separately from Company products or services. 
 4. NON-COMPETITION.
During the term of my employment by the Company, I will not without the prior written approval of (i) an executive officer of the Company, in the event that I am not an executive officer of the Company, and (ii) the Board of Directors of
the Company, in the event that I am an executive officer of the Company, (a) engage in any other professional employment or consulting, or (b) directly or indirectly participate in or assist any business which is a current or potential
supplier, customer or competitor of the Company. 

  
 3 

 5. NON-SOLICITATION. During the term of my employment with
the Company and for a period of one (1) year thereafter, I will not solicit or encourage, or cause others to solicit or encourage, any employees of the Company to terminate their employment with the Company. During the term of my employment
with the Company, I will not solicit the business of any customer or client of the Company on my own behalf or on behalf of any person or entity other than the Company. 

6. MISCELLANEOUS. The parties’ rights and obligations under this Agreement will bind and inure to the benefit of their respective
successors, heirs, executors, and administrators and permitted assigns. I will not assign this Agreement or its obligations hereunder without the prior written consent of the Company and any such purported assignment without consent shall be null
and void from the beginning. This Agreement constitutes the parties’ final, exclusive and complete understanding and agreement with respect to the subject matter hereof, and supersede all prior and contemporaneous understandings and agreements
relating to its subject matter. This Agreement may not be waived, modified or amended unless mutually agreed upon in writing by both parties. In the event any provision of this Agreement is found to be legally unenforceable, such unenforceability
shall not prevent enforcement of any other provision of the Agreement. I acknowledge that the Company will suffer substantial damages not readily ascertainable or compensable in terms of money in the event of the breach of any of my obligations
under this Agreement. I therefore agree that the Company shall be entitled (without limitation of any other rights or remedies otherwise available to the Company) to obtain an injunction from any court of competent jurisdiction prohibiting the
continuance or recurrence of any breach of this Agreement. The rights and obligations of the parties under this Agreement shall be governed in all respects by the laws of the State of California exclusively, without regard to conflict of law
provisions. I agree that upon Company’s request, all disputes arising hereunder shall be adjudicated in the state and federal courts having jurisdiction over disputes arising in San Francisco, California, and I hereby agree to consent to the
personal jurisdiction of such courts. Any notices required or permitted hereunder shall be given to the appropriate party at the address specified above or at such other address as the party shall specify in writing. Such notice shall be deemed
given upon personal delivery, or sent by certified or registered mail, postage prepaid, three (3) days after the date of mailing. This Agreement may be executed in any number of counterparts, each of which shall be deemed to be an original and
all of which together shall be deemed to be one and the same instrument. 

  
 4 

 I HAVE READ THIS AGREEMENT CAREFULLY AND I UNDERSTAND AND ACCEPT THE OBLIGATIONS WHICH IT IMPOSES UPON ME
WITHOUT RESERVATION. NO PROMISES OR REPRESENTATIONS HAVE BEEN MADE TO ME TO INDUCE ME TO SIGN THIS AGREEMENT. I SIGN THIS AGREEMENT VOLUNTARILY AND FREELY, IN DUPLICATE, WITH THE UNDERSTANDING THAT THE COMPANY WILL RETAIN ONE COUNTERPART AND THE
OTHER COUNTERPART WILL BE RETAINED BY ME. 
 IN WITNESS WHEREOF, I have executed this document as of the
6th day of April, 2014. 
  

							
		 		 	  /s/ Linda C. Bain

		 		 	Employee
			
	AGREED AND ACKNOWLEDGED:	 		 	
			
		 		 	Avalanche Biotechnologies
				
		 		 	By:	 	 /s/ Thomas Chalberg

		 		 	Name:	 	Thomas Chalberg
		 		 	Title:	 	President & CEO

  
 5 

 EXHIBIT A 

Termination Certificate 

I, the undersigned, hereby certify that I do not have in my possession, nor have I failed to return, any documents or materials relating to
the business of Company or its affiliates (the “Company”), or copies thereof, including, without limitation, any item of Confidential Information listed in Section 3 of the Company’s Employee Confidentiality And Inventions
Assignment Agreement (the “Agreement”) to which I am a party. 
 I further certify that I have complied with all of the terms of
the Agreement signed by me, including the reporting of any Inventions (as defined in the Agreement) covered by the Agreement. 
 I further
agree that in compliance with the Agreement, I will preserve as confidential any information relating to the Company or any of it business partners, clients, consultants or licensees which has been disclosed to me in confidence during the course of
my employment by the Company unless authorized in writing to do so (i) by an executive officer of the Company, in the event that I am not an executive officer of the Company, or (ii) by the Board of Directors of the Company, in the event
that I am an executive officer of the Company. 
  

					
	Date:                    	 		 	  

		 		 	(Employee’s Signature)
			
		 		 	  

		 		 	(Printed or Typed Name of Employee)

 EXHIBIT B 

California Labor Code 
 California Labor
Code § 2870. Application of provision providing that employee shall assign or offer to assign rights in invention to employer. 
  

	(a)	Any provision in an employment agreement which provides that an employee shall assign, or offer to assign, any of his or her rights in an invention to his or her employer shall not apply to an invention that the
employee developed entirely on his or her own time without using the employer’s equipment, supplies, facilities, or trade secret information except for those inventions that either: 

 

	 	(1)	Relate at the time of conception or reduction to practice of the invention to the employer’s business, or actual or demonstrably anticipated research or development of the employer; or 

 

	 	(2)	Result from any work performed by the employee for the employer. 

  

	(b)	To the extent a provision in an employment agreement purports to require an employee to assign an invention otherwise excluded from being required to be assigned under subdivision (a), the provision is against the
public policy of this state and is unenforceable. 

 EXHIBIT C 

BACKGROUND TECHNOLOGY 

(List here prior contracts to assign Inventions that are now in existence between any other person or entity and you.) 

(List here previous Inventions which you desire to have specifically excluded from the operation of this Agreement. Continue on reverse side
if necessary.)EX-10.9

 Exhibit 10.9 
  

			
	

	 	 665 Third Street, Suite 250, San Francisco, CA 94107

Tel +1-650-735-1324 | Fax +1-650-362-1908

 July 15, 2012 
 Hans P.
Hull, Esq. 
 [Address] 
 Re: Employment Terms For Director,
Corporate Development 
 Dear Hans: 
 This letter
agreement (the “Agreement”) memorializes the employment terms for your anticipated hire by Avalanche Biotechnologies, Inc. (the “Company”) in the position of Director of Corporate Development. These terms will become effective on
July 16, 2012 or at such later date by mutual agreement and as approved by the Board of Directors of the Company (as applicable, the “Hire Date”). Prior to the Hire Date, you will be retained by the Company on an independent
contractor basis under the terms of the separate Consulting Agreement between you and the Company, which will automatically expire no later than the Hire Date. 

Effective as of the Hire Date, your employment terms will be as follows: 
  

	1.	Duties; Reporting Relationship; Office Location. 

 In the position of Vice President, Legal and Corporate
Development, you will serve in an managerial capacity and will be required to perform the duties commonly associated with this position, including working with executive management to determine company strategy, fundraising, and corporate
development activities, organizing business and corporate development meetings, conducting day-to-day operational affairs, negotiating confidentiality and other agreements, and creating and tracking quarterly and annual budgets, as well as other
activities that may be assigned to you by the Company’s Chief Executive Officer (the “CEO”) from time to time. You will report to the CEO, and will work at the Company’s offices at 665 Third Street, Suite 250, San Francisco, as
well as other locations as determined on an as-needed basis, including the Company’s corporate headquarters in Redwood City and at Company meeting locations. 
  

	2.	Compensation and Benefits. 

 Your base salary will be $170,000 per annum, subject to payroll deductions
and all required withholdings, representing full-time employment with the Company. Your salary will be paid in accordance with the Company’s standard payroll schedule. In addition, you will be eligible to earn an annual performance bonus
provided that you are actively employed through and including December 31 of that year. In the hiring year, your bonus will be pro-rated from the Hire Date until the end of the bonus year. 

			
	

	 	 665 Third Street, Suite 250, San Francisco, CA 94107

Tel +1-650-735-1324 | Fax +1-650-362-1908

  

 Your annual bonus will be calculated based on attainment of individual goals (including corporate and
personal objectives) to be determined by the Company’s management each year. Bonus payments will be in the form of cash and/or incentive stock options, and will be granted entirely at the discretion of the Company’s CEO and Board of
Directors. Any cash bonus payments will be less payroll deductions and all required withholdings. 
 You will be eligible to participate in the
Company’s general employee benefits in accordance with the terms, conditions and limitations of the benefit plans to the extent such plans have been established by the Company. 

 

	3.	Incentive Stock Option grant. 

 In addition to the compensation and benefits described above, the Company
will grant you, subject to the approval of the Company’s board of directors and the Company successfully obtaining a permit from the applicable state authority, the option to purchase (in addition to the options granted previously pursuant to
the offer letter dated 2-1-2012) 55,000 shares of the Company’s common stock, representing approximately 0.75% of the fully diluted shares based on the current capitalization of the company, at the fair market value as determined by the
Company’s board of directors at the date of the grant. The foregoing stock option will be subject to the Company’s 2006 Equity Incentive Plan and standard form of stock option agreement (the “Option Agreement”), and shall provide
that the shares subject to such option vest in equal monthly installments over a period of forty-eight (48) months. 
  

	4.	Confidentiality and Proprietary Information Obligations. 

  

	 	(a)	Company Policies and Proprietary Information Agreement. you will be required to sign the Employee Proprietary Information and Inventions Assignment Agreement attached hereto as Exhibit A (the “Proprietary
Information Agreement”). 

  

	 	(b)	 Adverse or Outside Business Activities. Throughout your employment with the Company, you may engage in civic, academic teaching and lectures, and
not-for-profit activities so long as such activities do not interfere with the performance of your duties hereunder or present a conflict of interest with the Company. You may not engage in other employment or undertake any other commercial business
activities unless you obtain the prior written consent of the Company’s CEO. The Company may rescind its consent to your service as a director of all other corporations or participation in other business or public activities, if the Company, in
its sole discretion, determines that such activities compromise or threaten to compromise the Company’s reputational or business interests or conflict with your duties to the Company. In

			
	

	 	 665 Third Street, Suite 250, San Francisco, CA 94107

Tel +1-650-735-1324 | Fax +1-650-362-1908

  

	 	
addition, throughout the term of your employment with the Company, you agree not to, directly or indirectly, without the prior written consent of the Company, own, manage, operate, join, control,
finance or participate in the ownership, management, operation, control or financing of, or be connected as an officer, director, executive, partner, employee, principal, agent, representative, consultant, licensor, licensee or otherwise with, any
business or enterprise engaged in any business which is competitive with or which is reasonably anticipated to be competitive with the Company’s business; provided, however, that you may purchase or otherwise acquire up to (but not more than)
one percent (1%) of any class of securities of any enterprise (but without participating in the activities of such enterprise) if such securities are listed on any national or regional securities exchange. You hereby represent and warrant that
you have disclosed previously to the Board all other employment or other commercial business activities that you already undertake, or intend to undertake (to the extent currently known by you), during your period of employment with the Company.

  

	5.	No Conflicts. 

 By signing this Agreement you hereby represent to the Company that, except as previously
disclosed to the Company: (a) your employment with the Company is not prohibited under any employment agreement or other contractual arrangement; and (b) you do not know of any conflicts which would restrict your employment with the
Company. You hereby represent that you have disclosed to the Company any contract you have signed that may restrict your activities on behalf of the Company, and that you are presently in compliance with such contracts, if any. 

 

	6.	At Will Employment. 

 Your employment relationship with the Company will be an “at-will”
arrangement and this Agreement does not constitute a guarantee of employment for any specific period of time. This means that either you or the Company may terminate your employment at any time, with or without cause, and with or without advance
notice. This “at-will” employment relationship cannot be changed except in a written agreement approved by the Company and signed by you and by a duly authorized officer of the Company. 

 

	7.	Miscellaneous. 

 As required by law, your employment is contingent upon satisfactory proof of your
identity and legal authorization to work in the United States. This Agreement, together with your Proprietary Information Agreement, forms the complete and exclusive statement of your employment agreement with the Company. The employment terms in
this Agreement supersede any other agreements or promises 

			
	

	 	 665 Third Street, Suite 250, San Francisco, CA 94107

Tel +1-650-735-1324 | Fax +1-650-362-1908

  

 
made to you by anyone, whether oral or written, concerning your employment terms. Changes in your employment terms, other than those changes expressly reserved to the Company’s or
Board’s discretion in this Agreement, require a written modification approved by the Board and signed by you and a duly authorized member of the Board. This Agreement will bind the heirs, personal representatives, successors and assigns of both
you and the Company, and inure to the benefit of both you and the Company, their heirs, successors and assigns. If any provision of this Agreement is determined to be invalid or unenforceable, in whole or in part, this determination shall not affect
any other provision of this Agreement and the provision in question shall be modified so as to be rendered enforceable in a manner consistent with the intent of the parties insofar as possible under applicable law. This Agreement shall be construed
and enforced in accordance with the laws of the State of California without regard to conflicts of law principles. Any ambiguity in this Agreement shall not be construed against either party as the drafter. Any waiver of a breach of this Agreement,
or rights hereunder, shall be in writing and shall not be deemed to be a waiver of any successive breach or rights hereunder. This Agreement may be executed in counterparts which shall be deemed to be part of one original, and facsimile signatures
shall be equivalent to original signatures. 
 Please sign and date this letter and return it to me by the close of business on July 16, 2012 in
order to confirm your anticipated employment terms as set forth above. 
 We look forward to a productive and enjoyable work relationship with you. 

 

			
	Sincerely,
	Avalanche Biotechnologies, Inc.:
	
	 /s/ Tom Chalberg

	Thomas W. Chalberg, President and Chief Executive Officer
	
	Understood and Accepted:
	
	 /s/ Hans Hull

	Hans P. Hull
		
	Date:	 	 2/7/2012

			
	

	 	 665 Third Street, Suite 250, San Francisco, CA 94107

Tel +1-650-735-1324 | Fax +1-650-362-1908

  

 EXHIBIT A 

EMPLOYEE PROPRIETARY INFORMATION AND INVENTIONS ASSIGNMENT 

AGREEMENT 

 EMPLOYEE CONFIDENTIAL INFORMATION AND INVENTIONS ASSIGNMENT AGREEMENT 

In consideration of my employment or continued employment by Avalanche Biotechnologies, Inc. (“Company”), and the
compensation paid to me now and during my employment with the Company, I agree to the terms of this Agreement as follows: 

 

 1. CONFIDENTIAL INFORMATION PROTECTIONS. 

1.1 Nondisclosure; Recognition of Company’s Rights. At all times during and after my employment, I will hold in confidence and
will not disclose, use, lecture upon, or publish any of Company’s Confidential Information (defined below), except as may be required in connection with my work for Company, or as expressly authorized by the Chief Executive Officer (the
“CEO”) of Company. I will obtain the CEO’s written approval before publishing or submitting for publication any material (written, oral, or otherwise) that relates to my work at Company and/or incorporates any Confidential
Information. I hereby assign to Company any rights I may have or acquire in any and all Confidential Information and recognize that all Confidential Information shall be the sole and exclusive property of Company and its assigns. 

1.2 Confidential Information. The term “Confidential Information” shall mean any and all confidential knowledge,
data or information related to Company’s business or its actual or demonstrably anticipated research or development, including without limitation (a) trade secrets, inventions, ideas, processes, computer source and object code, data,
formulae, programs, other works of authorship, know-how, improvements, discoveries, developments, designs, and techniques; (b) information regarding products, services, plans for research and development, marketing and business plans, budgets,
financial statements, contracts, prices, suppliers, and customers; (c) information regarding the skills and compensation of Company’s employees, contractors, and any other service providers of Company; and (d) the existence of any
business discussions, negotiations, or agreements between Company and any third party. 
 1.3 Third Party Information. I understand
that Company has received and in the future will receive from third parties confidential or proprietary information (“Third Party Information”) subject to a duty on Company’s part to maintain the confidentiality
of such information and to use it only for certain limited purposes. During and after the term of my employment, I will hold Third Party Information in strict confidence and will not disclose to anyone (other than Company personnel who need to know
such information in connection with their work for Company) or use, Third Party Information, except in connection with my work for Company or unless expressly authorized by an officer of Company in writing. 

1.4 No Improper Use of Information of Prior Employers and Others. I represent that my employment by Company does not and will not
breach any agreement with any former employer, including any noncompete agreement or any agreement to keep in confidence or refrain from using

 
information acquired by me prior to my employment by Company. I further represent that I have not entered into, and will not enter into, any agreement, either written or oral, in conflict with my
obligations under this Agreement. During my employment by Company, I will not improperly make use of, or disclose, any information or trade secrets of any former employer or other third party, nor will I bring onto the premises of Company or use any
unpublished documents or any property belonging to any former employer or other third party, in violation of any lawful agreements with that former employer or third party. I will use in the performance of my duties only information that is
generally known and used by persons with training and experience comparable to my own, is common knowledge in the industry or otherwise legally in the public domain, or is otherwise provided or developed by Company. 

2. INVENTIONS. 
 2.1
Definitions. As used in this Agreement, the term “Invention” means any ideas, concepts, information, materials, processes, data, programs, know-how, improvements, discoveries, developments, designs, artwork,
formulae, other copyrightable works, and techniques and all Intellectual Property Rights in any of the items listed above. The term “Intellectual Property Rights” means all trade secrets, copyrights, trademarks, mask
work rights, patents and other intellectual property rights recognized by the laws of any jurisdiction or country. The term “Moral Rights” means all paternity, integrity, disclosure, withdrawal, special and any other
similar rights recognized by the laws of any jurisdiction or country. 
 2.2 Prior Inventions. I have disclosed on Exhibit A
a complete list of all Inventions that (a) I have, or I have caused to be, alone or jointly with others, conceived, developed, or reduced to practice prior to the commencement of my employment by Company; (b) in which I have an ownership
interest or which I have a license to use; (c) and that I wish to have excluded from the scope of this Agreement (collectively referred to as “Prior Inventions”). If no Prior Inventions are listed in Exhibit A, I warrant
that there are no Prior Inventions. I agree that I will not incorporate, or permit to be incorporated, Prior Inventions in any Company Inventions (defined below) without Company’s prior written consent. If, in the course of my employment with
Company, I incorporate a Prior Invention into a Company process, machine or other work, I hereby grant Company a non-exclusive, perpetual, fully-paid and royalty-free, irrevocable and worldwide license, with rights to sublicense through multiple
levels of sublicensees, to reproduce, make derivative works of, distribute, publicly perform, and publicly display in any form or medium, whether now known or later developed, make, have made, use, sell, import, offer for sale, and exercise any and
all present or future rights in, such Prior Invention. 

 

  
 1 

 2.3 Assignment of Company Inventions. Inventions assigned to the Company or to a third
party as directed by the Company pursuant to the subsection titled Government or Third Party are referred to in this Agreement as “Company Inventions.” Except for Inventions (a) that are subject to the subsection titled
Government or Third Party, (b) that qualify fully under the provisions of California Labor Code section 2870, or (c) any Prior Inventions that I have set forth in Exhibit A, I hereby assign and agree to assign in the future
(when any such Inventions or Intellectual Property Rights are first reduced to practice or first fixed in a tangible medium, as applicable) to Company all my right, title, and interest in and to any and all Inventions (and all Intellectual Property
Rights with respect thereto) made, conceived, reduced to practice, or learned by me, either alone or with others, during the period of my employment by Company. Any assignment of Inventions (and all Intellectual Property Rights with respect thereto)
hereunder includes an assignment of all Moral Rights. To the extent such Moral Rights cannot be assigned to Company and to the extent the following is allowed by the laws in any country where Moral Rights exist, I hereby unconditionally and
irrevocably waive the enforcement of such Moral Rights, and all claims and causes of action of any kind against Company or related to Company’s customers, with respect to such rights. I further acknowledge and agree that neither my
successors-in-interest nor legal heirs retain any Moral Rights in any Inventions (and any Intellectual Property Rights with respect thereto). I have reviewed the notification on Exhibit A (Limited Exclusion Notification) and agree that this
signed Agreement acknowledges my receipt of the notification. 
 2.4 Obligation to Keep Company Informed. During the period of my
employment and for one (1) year after my employment ends, I will promptly and fully disclose to Company in writing (a) all Inventions authored, conceived, or reduced to practice by me, either alone or with others, including any that might
be covered under California Labor Code section 2870, and (b) all patent applications filed by me or in which I am named as an inventor or co-inventor. 

2.5 Government or Third Party. I agree that, as directed by the Company, I will assign to a third party, including without limitation
the United States, all my right, title, and interest in and to any particular Company Invention. 
 2.6 Enforcement of Intellectual
Property Rights and Assistance. During and after the period of my employment and at Company’s request and expense, I will assist Company in every proper way, including consenting to and joining in any action, to obtain and enforce United
States and foreign Intellectual Property Rights and Moral Rights relating to Company Inventions in all countries. If the Company is unable to secure my signature on any document needed in connection with such purposes, I hereby irrevocably designate
and appoint Company and its duly authorized officers and agents as my agent and attorney in fact, which appointment is coupled with an interest, to act on my behalf to execute and file any such documents and to do all other lawfully permitted

 
acts to further such purposes with the same legal force and effect as if executed by me. 

2.7 Incorporation of Software Code. I agree that I will not incorporate into any Company software or otherwise deliver to Company any
software code licensed under the GNU General Public License or Lesser General Public License or any other license that, by its terms, requires or conditions the use or distribution of such code on the disclosure, licensing, or distribution of any
source code owned or licensed by Company. 
 3. RECORDS. I agree to keep and maintain adequate and current records (in the form
of notes, sketches, drawings and in any other form that is required by the Company) of all Inventions made by me during the period of my employment by the Company, which records shall be available to, and remain the sole property of, the Company at
all times. 
 4. ADDITIONAL ACTIVITIES. I agree that during the term of my
employment by Company, I will not (a) without Company’s express written consent, engage in any employment or business activity that is competitive with, or would otherwise conflict with my employment by, Company; and (b) for the
period of my employment by Company and for one (1) year thereafter, I will not either directly or indirectly, solicit or attempt to solicit any employee, independent contractor, or consultant of Company to terminate his, her or its relationship
with Company in order to become an employee, consultant, or independent contractor to or for any other person or entity. 
 5. RETURN
OF COMPANY PROPERTY. Upon termination of my employment or upon Company’s request at any other time, I will deliver to Company all of Company’s property, equipment, and documents, together
with all copies thereof, and any other material containing or disclosing any Inventions, Third Party Information or Confidential Information and certify in writing that I have fully complied with the foregoing obligation. I agree that I will not
copy, delete, or alter any information contained upon my Company computer or Company equipment before I return it to Company. In addition, if I have used any personal computer, server, or e-mail system to receive, store, review, prepare or transmit
any Company information, including but not limited to, Confidential Information, I agree to provide the Company with a computer-useable copy of all such Confidential Information and then permanently delete and expunge such Confidential Information
from those systems; and I agree to provide the Company access to my system as reasonably requested to verify that the necessary copying and/or deletion is completed. I further agree that any property situated on Company’s premises and owned by
Company is subject to inspection by Company’s personnel at any time with or without notice. Prior to the termination of my employment or promptly after termination of my employment, I will cooperate with Company in attending an exit interview
and certify in writing that I have complied with the requirements of this section. 

 

  
 2 

 
 6. NOTIFICATION OF NEW EMPLOYER. If I leave
the employ of Company, I consent to the notification of my new employer of my rights and obligations under this Agreement, by Company providing a copy of this Agreement or otherwise. 

7. GENERAL PROVISIONS. 

7.1 Governing Law and Venue. This Agreement and any action related thereto will be governed and interpreted by and under the laws of
the State of California, without giving effect to any conflicts of laws principles that require the application of the law of a different state. I expressly consent to personal jurisdiction and venue in the state and federal courts for the county in
which Company’s principal place of business is located for any lawsuit filed there against me by Company arising from or related to this Agreement. 

7.2 Severability. If any provision of this Agreement is, for any reason, held to be invalid or unenforceable, the other provisions of
this Agreement will remain enforceable and the invalid or unenforceable provision will be deemed modified so that it is valid and enforceable to the maximum extent permitted by law. 

7.3 Survival. This Agreement shall survive the termination of my employment and the assignment of this Agreement by Company to any
successor or other assignee and shall be binding upon my heirs and legal representatives. 
 7.4 Employment. I agree and understand
that nothing in this Agreement shall give me any right to continued employment by Company, and it will not interfere in any way with my right or Company’s right to terminate my employment at any time, with or without cause and with or without
advance notice. 
 7.5 Notices. Each party must deliver all notices or other communications required or permitted under this
Agreement in writing to the other party at the address listed on the signature page, by courier, by certified or registered mail (postage prepaid and return receipt requested), or by a nationally-recognized express mail service. Notice will be
effective upon receipt or refusal of delivery. If delivered by certified or registered mail, notice will be considered to have been given five (5) business days after it was mailed, as evidenced by the postmark. If delivered by courier or
express mail service, notice will be considered to have been given on

 
the delivery date reflected by the courier or express mail service receipt. Each party may change its address for receipt of notice by giving notice of the change to the other party. 

7.6 Injunctive Relief. I acknowledge that, because my services are personal and unique and because I will have access to the
Confidential Information of Company, any breach of this Agreement by me would cause irreparable injury to Company for which monetary damages would not be an adequate remedy and, therefore, will entitle Company to injunctive relief (including
specific performance). The rights and remedies provided to each party in this Agreement are cumulative and in addition to any other rights and remedies available to such party at law or in equity. 

7.7 Waiver. Any waiver or failure to enforce any provision of this Agreement on one occasion will not be deemed a waiver of that
provision or any other provision on any other occasion. 
 7.8 Export. I agree not to export, reexport, or transfer, directly or
indirectly, any U.S. technical data acquired from Company or any products utilizing such data, in violation of the United States export laws or regulations. 

7.9 Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be deemed an original and all of
which shall be taken together and deemed to be one instrument. 
 7.10 Entire Agreement. If no other agreement governs
nondisclosure and assignment of inventions during any period in which I was previously employed or am in the future employed by Company as an independent contractor, the obligations pursuant to sections of this Agreement titled Confidential
Information Protections and Inventions shall apply. This Agreement is the final, complete and exclusive agreement of the parties with respect to the subject matter hereof and supersedes and merges all prior communications between us with respect to
such matters. No modification of or amendment to this Agreement, or any waiver of any rights under this Agreement, will be effective unless in writing and signed by me and the CEO of Company. Any subsequent change or changes in my duties, salary or
compensation will not affect the validity or scope of this Agreement.  

 

  
 This Agreement shall be
effective as of the first day of my employment with Company. 

  
 3 

									
	EMPLOYEE:	 		 	AVALANCHE BIOTECHNOLOGIES, INC.:
			
	I HAVE READ, UNDERSTAND, AND ACCEPT THIS AGREEMENT AND HAVE BEEN
GIVEN THE OPPORTUNITY TO REVIEW IT WITH INDEPENDENT LEGAL COUNSEL.	 		 	ACCEPTED AND AGREED:
			
	 /s/ Hans Hull
	 		 	 /s/ Thomas W. Chalberg

	(Signature)	 		 	(Signature)
					
	By:	 	 Hans Hull
	 		 	By:	 	Thomas W. Chalberg
					
	Title:	 	 VP Legal & Corp Dev
	 		 	Title:	 	President & CEO
					
	Date:	 	 2/7/2012
	 		 	Date:	 	February 6, 2012
					
	Address:	 	 [address]
	 		 	Address:	 	665 Third Street, Suite 250, San Francisco, CA 94107

  
 4 

 EXHIBIT A 

INVENTIONS 
 1. Prior Inventions
Disclosure. The following is a complete list of all Prior Inventions (as provided in Subsection 2.2 of the attached Employee Confidential Information and Inventions Assignment Agreement, defined herein as the “Agreement”): 

 

					
		  	 ̈	 	None
			
		  	 ̈	 	See immediately below:
		
		  	  

		
		  	  

 2. Limited Exclusion Notification. 

THIS IS TO NOTIFY you in accordance with Section 2872
of the California Labor Code that the foregoing Agreement between you and Company does not require you to assign or offer to assign to Company any Invention that you develop entirely on your own time without using Company’s equipment, supplies,
facilities or trade secret information, except for those Inventions that either: 
 a. Relate at the time of conception or reduction
to practice to Company’s business, or actual or demonstrably anticipated research or development; or 
 b. Result from any work
performed by you for Company. 
 To the extent a provision in the foregoing Agreement purports to require you to assign an Invention
otherwise excluded from the preceding paragraph, the provision is against the public policy of this state and is unenforceable. 
 This
limited exclusion does not apply to any patent or Invention covered by a contract between Company and the United States or any of its agencies requiring full title to such patent or Invention to be in the United States. 

  
 A-1

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