Document:

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                                                                   EXHIBIT 10.44

                          AMYLIN PHARMACEUTICALS, INC.
                           CHANGE IN CONTROL EMPLOYEE
                             SEVERANCE BENEFIT PLAN

SECTION 1. INTRODUCTION

        The Amylin Pharmaceuticals, Inc. Change in Control Employee Severance
Benefit Plan (the "Plan") is designed to provide separation pay and benefits to
eligible terminating employees. This document constitutes the written instrument
under which the Plan is maintained and supersedes any prior plan or practice of
the Company that provides for the payment of severance benefits to eligible
employees in the form of cash and non-equity related benefits. The Plan was
approved by the Compensation Committee of the Board of Directors of the Company
effective February 8, 2001.

DEFINITIONS

        For purposes of this Plan, the following terms shall have the meanings
set forth below:

        (a)    "AFFILIATE" means any corporation (other than the Company) in an
unbroken chain of corporations beginning with the Company, if each of the
corporations other then the last corporation in the unbroken chain owns stock
possessing fifty percent (50%) or more of the total combined voting power of all
classes of stock in one of the other corporations in such chain.

        (b)    "BOARD" means the Board of Directors of the Company.

        (c)    "CAUSE" means, with respect to a Covered Employee, that, in the
reasonable determination of the Company, such Covered Employee has (i) been
convicted of or pleaded guilty or nolo contendere to a felony or any crime
involving moral turpitude or dishonesty; (ii) participated in a fraud or act of
dishonesty against the Company; (iii) willfully and materially breached a
Company policy; (iv) intentionally damaged the Company's property; (v) willfully
and materially breached such Covered Employee's Proprietary Information and
Inventions Agreement with the Company; (vi) engaged in conduct that, in the
reasonable determination of the Company, demonstrates gross unfitness to serve;
or (vii) repeatedly failed to satisfactorily perform job duties to which such
Covered Employee previously agreed in writing. The conduct described under
clauses (iii), (vi) and (vii) above will only constitute Cause if such conduct
is not cured within 90 days after the Covered Employee's receipt of written
notice from the Company or the Board specifying the particulars of the conduct
that may constitute Cause.

        (d)    "CHANGE IN CONTROL" means the occurrence of any of the following:

               (i)    any "person," as such term is used in Sections 13(d) and
14(d) of the Securities and Exchange Act of 1934, as amended from time to time,
and any successor statute (the "Exchange Act") (other than the Company, a
subsidiary, an affiliate, or a Company employee benefit plan, including any
trustee of such plan acting as trustee) is or becomes the "beneficial owner" (as
defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of
securities of the Company representing 50% or more of the combined voting power
of the

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Company's then outstanding securities other than by virtue of a merger,
consolidation or similar transaction;

               (ii)   there is consummated a sale or other disposition of all or
substantially of assets of the Company (other than a sale to an entity where at
least 50% of the combined voting power of the voting securities of such entity
are owned by the stockholders of the Company in substantially the same
proportions as their ownership of the Company immediately prior to such sale);

               (iii)  there is consummated a merger, consolidation or similar
transaction involving (directly or indirectly) the Company and, immediately
after the consummation of such transaction, the stockholders immediately prior
to the consummation of such transaction do not own, directly or indirectly,
outstanding voting securities representing more than 50% of the combined
outstanding voting power of the surviving entity in such transaction or more
than 50% of the combined outstanding voting power of the parent of the surviving
entity in such transaction.

        (e)    "COMPANY" means Amylin Pharmaceuticals, Inc., a Delaware
corporation and its Affiliates, or following a Change in Control, the surviving
entity resulting from such transaction.

        (f)    "CONSTRUCTIVE TERMINATION" means, with respect to a Covered
Employee, that such Covered Employee voluntarily terminates his or her
employment with the Company after any of the following are undertaken without
Cause and without such Covered Employee's express written consent:

               (i)    a reduction by the Company in such Covered Employee's
annual base salary as in effect during the last regularly scheduled payroll
period immediately prior to the effective date of the Change in Control (or as
increased thereafter), unless such reduction is made pursuant to an
across-the-board reduction of the base salaries of all similarly situated
Covered Employee's of no more than ten percent (10%);

               (ii)   such Covered Employee's relocation, or the relocation of
the Company's principal executive offices if such Covered Employee's principal
office is at such offices, to a location more than fifty (50) miles from the
location at which such Covered Employee was performing his or her duties
immediately prior to the effective date of the Change in Control, except for
required travel on the Company's business to an extent substantially consistent
with such Covered Employee's business travel obligations immediately prior to
the effective date of the Change in Control;

               (iii)  such Covered Employee's assignment of any duties or
responsibilities that results in a material diminution in such Covered
Employee's authority, duties or responsibilities as in effect immediately prior
to the Change in Control;

               (iv)   a material breach by the Company of any provision of this
Plan or any enforceable written agreement between such Covered Employee and the
Company; or

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               (v)    any failure by the Company to obtain the assumption of
this Plan by any successor or assign of the Company.

        (g)    "COVERED EMPLOYEE" means a person eligible to participate in the
Plan as provided in Section 3 herein.

        (h)    "INVOLUNTARY TERMINATION WITHOUT CAUSE" means with respect to a
Covered Employee such Covered Employee's dismissal or discharge by the Company
for a reason other than for Cause. The termination of a Covered Employee's
employment will not be deemed to be an "Involuntary Termination Without Cause"
if such Covered Employee's termination occurs as a result of such Covered
Employee's death or disability.

SECTION 3. ELIGIBILITY AND PARTICIPATION

        A person is eligible to participate in the Plan if (i) such person is an
employee of the Company or an Affiliate with the title of Vice-President or
higher; (ii) such person has not entered into an individual severance benefit or
change in control agreement with the Company (excluding any plan or arrangement,
or any portion thereof, relating to equity compensation); (iii) the Board has
designated such person as eligible to participate in this Plan; and (iv) such
person's employment with the Company terminates due to an Involuntary
Termination Without Cause or a Constructive Termination, in either case within
90 days prior to or thirteen (13) months following the effective date of a
Change in Control.

SECTION 4. BENEFITS

        Each Covered Employee is eligible to receive the following benefits;
provided that, if a Covered Employee's receipt of such potential benefits would
cause a contemplated Change in Control transaction that would otherwise be
eligible to be accounted for as a "pooling-of-interests" transaction to become
ineligible for such accounting treatment under generally accepted accounting
principles as determined by the Accountants prior to the Change in Control, and
such accounting treatment was desired by the Company, then such Covered Employee
shall not be eligible to receive such benefits.

        (b)    SALARY CONTINUATION. The Company shall continue the base salary
of each Covered Employee, as in effect on the date of the Constructive
Termination or Involuntary Termination Without Cause, as the case may be, for a
period of eighteen (18) months (twenty-four (24) months if such Covered Employee
is the Chief Executive Officer or President of the Company). Such amount shall
be paid to each such Covered Employee in regular installments on the normal
payroll dates of the Company or over a shorter period, as determined by the
Company. Any salary continuation payments that such Covered Employee receive
shall be subject to all required tax withholding.

        (c)    BONUS PAYMENT. The Company shall pay to each Covered Employee a
cash bonus in an amount that would have been paid to such Covered Employee as a
bonus payment if the Company had achieved the goals established in the Company's
Cash Bonus Plan then in effect for the year in which such termination occurs,
and assuming that such Covered Employee's performance rating for that year
entitled such Covered Employee to one hundred percent (100%) of the target bonus
established under such Cash Bonus Plan, plus any earned but

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unpaid Cash Bonus for a preceding period. Any such bonus payment pursuant to
this Section 4(b) shall be in a single lump sum to be paid on the date of such
Constructive Termination or Involuntary Termination Without Cause, as the case
may be. Any bonus payments that such Covered Employee receive shall be subject
to all required tax withholding.

        (d)    RELEASE. To receive benefits under this Plan, a Covered Employee
or his or her representative must execute a release of claims in favor of the
Company, in the form attached to this Plan as Exhibit A or Exhibit B, as
appropriate, and such release must become effective in accordance with its
terms.

        (e)    TERMINATION OF BENEFITS. With respect to each Covered Employee,
benefits under this Plan shall terminate immediately if such Covered Employee,
at any time, violates any proprietary information, confidentiality or
non-solicitation obligation to the Company.

        (f)    NON-DUPLICATION OF BENEFITS. No Covered Employee is eligible to
receive benefits under this Plan more than one time.

SECTION 5. PARACHUTE PAYMENTS

        In the event that the payments provided herein and benefits otherwise
payable to a Covered Employee (i) constitute "parachute payments" within the
meaning of Section 280G of the Code, or any comparable successor provisions, and
(ii) but for this Section 5 would be subject to the excise tax imposed by
Section 4999 of the Code, or any comparable successor provisions (the "Excise
Tax"), then such Covered Employee's benefits hereunder shall be either:

               (i)    provided to such Covered Employee in full, or

               (ii)   provided to such Covered Employee as to such lesser extent
                      which would result in no portion of such benefits being
                      subject to the Excise Tax,

whichever of the foregoing amounts, when taking into account applicable federal,
state, local and foreign income and employment taxes, the Excise Tax, and any
other applicable taxes, results in the receipt by such Covered Employee, on an
after-tax basis, of the greatest amount of benefits, notwithstanding that all or
some portion of such benefits may be taxable under the Excise Tax. Unless the
Company and such Covered Employee otherwise agree in writing, any determination
required under this Section 5 shall be made in writing in good faith by the
Company's independent certified public accountants (the "Accountants"). In the
event of a reduction of benefits hereunder, such Covered Employee shall be given
the choice of which benefits to reduce. For purposes of making the calculations
required by this Section, the Accountants may make reasonable assumptions and
approximations concerning applicable taxes and may rely on reasonable, good
faith interpretations concerning the application of the Code, and other
applicable legal authority. The Company and such Covered Employee shall furnish
to the Accountants such information and documents as the Accountants may
reasonably request in order to make a determination under this Section 5. The
Company shall bear all costs the Accountants may reasonably incur in connection
with any calculations contemplated by this Section 5.

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        If, notwithstanding any reduction described in this Section 5, the IRS
determines that such Covered Employee is liable for the Excise Tax as a result
of the receipt of the payment of benefits as described above, then such Covered
Employee shall be obligated to pay back to the Company, within thirty (30) days
after a final IRS determination or in the event that such Covered Employee
challenges the final IRS determination, a final judicial determination, a
portion of the payment equal to the "Repayment Amount." The Repayment Amount
with respect to the payment of benefits shall be the smallest such amount, if
any, as shall be required to be paid to the Company so that such Covered
Employee's net after-tax proceeds with respect to any payment of benefits (after
taking into account the payment of the Excise Tax and all other applicable taxes
imposed on such payment) shall be maximized. The Repayment Amount with respect
to the payment of benefits shall be zero if a Repayment Amount of more than zero
would not result in such Covered Employee's net after-tax proceeds with respect
to the payment of such benefits being maximized. If the Excise Tax is not
eliminated pursuant to this paragraph, such Covered Employee shall pay the
Excise Tax.

        Notwithstanding any other provision of this Section 5, if (i) there is a
reduction in the payment of benefits as described in this Section, (ii) the IRS
later determines that such Covered Employee is liable for the Excise Tax, the
payment of which would result in the maximization of such Covered Employee's net
after-tax proceeds (calculated as if such Covered Employee's benefits had not
previously been reduced), and (iii) such Covered Employee pays the Excise Tax,
then the Company shall pay to such Covered Employee those benefits which were
reduced pursuant to this Section 5 contemporaneously or as soon as
administratively possible after such Covered Employee pays the Excise Tax so
that such Covered Employee's net after-tax proceeds with respect to the payment
of benefits is maximized.

               If a Covered Employee either (i) brings any action to enforce
such Covered Employee's rights pursuant to this Section, or (ii) defends any
legal challenge to such Covered Employee's rights hereunder, such Covered
Employee shall be entitled to recover attorneys' fees and costs incurred in
connection with such action, regardless of the outcome of such action; provided,
however, that in the event such action is commenced by such Covered Employee,
the court finds the claim was brought in good faith.

SECTION 6. ADMINISTRATION AND OPERATION OF THE PLAN

        The Company is the "Plan Sponsor" and the "Plan Administrator" of the
Plan, as such terms are defined in the Employee Retirement Income Security Act
of 1974 ("ERISA"). The Company, in its capacity as Plan Administrator of the
Plan, is the named fiduciary that has the authority to control and manage the
operation and administration of the Plan. The Company has the sole discretion to
make such rules, regulations, interpretations of the Plan and computations and
shall take such other action to administer the Plan as it may deem appropriate
in its sole discretion. Such rules, regulations, interpretations, computations,
and other actions shall be conclusive and binding upon all persons. The Company
may engage the services of such persons or organizations to render advice or
perform services with respect to its responsibilities under the Plan as it shall
determine to be necessary or appropriate. Such persons or organizations may
include (without limitation) actuaries, attorneys, accountants and consultants.

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        Any person or group of persons may serve in more than one fiduciary
capacity with respect to the Plan. The responsibilities of the Company under the
Plan shall be carried out on its behalf by its directors, officers, employees
and agents, acting on behalf or in the name of the Company in their capacity as
directors, officers, employees and agents and not as individual fiduciaries. The
Company may delegate any of its fiduciary responsibilities under the Plan to
another person or persons pursuant to a written instrument that specifies the
fiduciary responsibilities so delegated to each such person.

SECTION 7. CLAIMS, INQUIRIES AND APPEALS

        (a)    APPLICATIONS FOR BENEFITS AND INQUIRIES. Applications for
benefits should be in writing, signed and submitted to: Plan Administrator,
Change in Control Employee Severance Benefit Plan, Amylin Pharmaceuticals, Inc.,
9373 Towne Centre Drive, Suite 250, San Diego, California 92121 or such other
address as may be determined by the Company or its successor following notice to
each Covered Employee at the address of the Covered Employee in the Company's
personnel records.

        (b)    DENIAL OF CLAIMS. If any application for benefits is denied in
whole or in part, the Plan Administrator must notify each affected Covered
Employee, in writing, of the denial of the application, and of each such Covered
Employee's right to review the denial. The written notice of denial will be set
forth in a manner designed to be understood, and will include specific reasons
for the denial, specific references to the Plan provision upon which the denial
is based, a description of any information or material that the Plan
Administrator needs to complete the review and an explanation of the Plan's
review procedure.

        This written notice will be given to each affected Covered Employee
within thirty (30) days after the Plan Administrator receives the application,
unless special circumstances require an extension of time, in which case, the
Plan Administrator has up to an additional thirty (30) days for processing the
application. If an extension of time for processing is required, written notice
of the extension will be furnished to such Covered Employee before the end of
the initial 30-day period.

        This notice of extension will describe the special circumstances
necessitating the additional time and the date by which the Plan Administrator
is to render its decision on the application. If written notice of denial of the
application for benefits is not furnished within the specified time, the
application shall be deemed to be denied. Such Covered Employee will then be
permitted to appeal the denial in accordance with the review procedure described
below.

        (c)    REQUEST FOR REVIEW. A Covered Employee (or such Covered
Employee's authorized representative) may appeal a denied benefit claim by
submitting a written request for a review to: Review Panel, Change in Control
Employee Severance Benefit Plan, Amylin Pharmaceuticals, Inc., 9373 Towne Centre
Drive, Suite 250, San Diego, California 92121. The Review Panel shall be
comprised of two (2) or more persons to be appointed by the Company. Such
Covered Employee's appeal must be submitted within sixty (60) days after the
application is denied (or deemed denied). The Review Panel will give such
Covered Employee (or such Covered Employee's representative) an opportunity to
review pertinent documents in preparing a request for a review.

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        A request for review must set forth all of the grounds on which it is
based, all facts in support of the request and any other matters that a Covered
Employee or such Covered Employee's representative feels are pertinent. The
Review Panel may require such Covered Employee or such Covered Employee's
representative to submit additional facts, documents or other material as it may
find necessary or appropriate in making its review.

        (d)    DECISION ON REVIEW. The Review Panel will act on each request for
review within thirty (30) days after receipt of the request, unless special
circumstances require an extension of time (not to exceed an additional thirty
(30) days) for processing the request for a review. If an extension for review
is required, written notice of the extension will be furnished within the
initial 30-day period. The Review Panel will give written notice of its decision
to the applicant. In the event that the Review Panel confirms the denial of the
application for benefits in whole or in part, the notice will outline the
specific Plan provisions upon which the decision is based. If written notice of
the Review Panel's decision is not given within the time prescribed above, the
application will be deemed denied on review.

        (e)    RULES AND PROCEDURES. The Plan Administrator and/or the Review
Panel may establish rules and procedures, consistent with the Plan and with
ERISA, as necessary and appropriate in carrying out their responsibilities in
reviewing benefit claims. If a Covered Employee wishes to submit additional
information in connection with an appeal from the denial (or deemed denial) of
benefits, such Covered Employee may be required to do so at his or her own
expense.

        (f)    EXHAUSTION OF REMEDIES. No legal action for benefits under the
Plan may be brought until (i) a written application for benefits has been
submitted in accordance with the procedures described above, (ii) the person
claiming benefits has been notified by the Plan Administrator that the
application is denied (or the application is deemed denied due to the Plan
Administrator's failure to act on it within the time prescribed), (iii) a
written request for a review of the application has been submitted in accordance
with the appeal procedure described above and (iv) the person appealing the
denial has been notified in writing that the Review Panel has denied the appeal
(or the appeal is deemed to be denied due to the Review Panel's failure to take
any action on the claim within the time prescribed).

SECTION 8. OTHER TERMINATIONS

        A Covered Employee is NOT eligible for benefits under this Plan if (i)
such Covered Employee's employment terminates due to death, disability or any
other reason other than an Involuntary Termination Without Cause or a
Constructive Termination that occurs within 90 days prior to or within thirteen
(13) months following the effective date of a Change in Control; (ii) such
Covered Employee is terminated within thirty (30) days of such Covered
Employee's refusal to accept an offer of comparable employment by any successor
to the Company or an Affiliate thereof (provided that "comparable employment"
shall mean employment with base salary in an amount not violative of Section
2(f)(i) and at a business office whose location is not violative of Section
2(f)(ii)); or (iii) such Covered Employee is terminated following such Covered
Employee's refusal to allow any successor to or Affiliate of the Company access
to such Covered Employee's employment records or access to Company personnel
regarding such

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Covered Employee's performance for the purpose of evaluating such Covered
Employee's qualifications for future employment.

SECTION 9. BASIS OF PAYMENTS TO AND FROM THE PLAN

        All benefits under the Plan shall be paid by the Company. The Plan shall
be unfunded and benefits hereunder shall be paid only from the general assets of
the Company.

SECTION 10. AMENDMENT AND TERMINATION

        The Company reserves the right to amend or terminate this Plan at any
time; provided, however, that this Plan may not be amended or terminated within
90 days prior to or at any time following the occurrence of a Change in Control
but shall, in any event, terminate on February 7, 2004 if a Change in Control
has not occurred before that date.

SECTION 11. NON-ALIENATION OF BENEFITS

        No Plan benefit may be anticipated, alienated, sold, transferred,
assigned, pledged, encumbered or charged, and any attempt to do so will be void.

SECTION 12. SUCCESSORS AND ASSIGNS

        This Plan shall be binding upon any surviving entity resulting from a
Change in Control and upon any other person who is a successor by merger,
acquisition, consolidation or otherwise to the business formerly carried on by
the Company without regard to whether or not such person actively adopts or
formally continues the Plan. Covered Employees, to the extent they are otherwise
eligible for benefits under the Plan, are intended third party beneficiaries of
this provision.

SECTION 13. LEGAL CONSTRUCTION

        This Plan shall be interpreted in accordance with ERISA and, to the
extent not preempted by ERISA, with the laws of the State of California. This
Plan constitutes both a plan document and a summary plan description for
purposes of ERISA.

SECTION 14. OTHER PLAN INFORMATION

        EMPLOYER IDENTIFICATION NUMBER: 33-026609

        ENDING OF THE PLAN'S FISCAL YEAR: December 31.

        AGENT FOR THE SERVICE OF LEGAL PROCESS: The Plan's agent for service of
legal process is: Joseph C. Cook, Jr., Chairman and Chief Executive Officer,
Amylin Pharmaceuticals, Inc., 9373 Towne Centre Drive, San Diego, California
92121.

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SECTION 15. STATEMENT OF ERISA RIGHTS

        The terms "you" and "your" shall apply to each Covered Employee, as
applicable. As a participant in this Plan (which is a welfare benefit plan
sponsored by the Company) you are entitled to certain rights and protections
under ERISA, including the right to:

        (a)    Examine, without charge, at the Plan Administrator's office and
at other specified locations, such as work sites, all Plan documents and copies
of all documents filed by the Plan with the U.S. Department of Labor, such as
detailed annual reports;

        (b)    Obtain copies of all Plan documents and Plan information upon
written request to the Plan Administrator. The Plan Administrator may make a
reasonable charge for the copies; and

        (c)    Receive a summary of the Plan's annual financial report, in the
case of a plan which is required to file an annual financial report with the
Department of Labor.

        In addition to creating rights for Plan participants, ERISA imposes
duties upon the people responsible for the operation of the employee benefit
plan. The people who operate the Plan, called "fiduciaries" of the Plan, have a
duty to do so prudently and in the interest of you and other Plan participants
and beneficiaries.

        No one, including your employer or any other person, may fire you or
otherwise discriminate against you in any way to prevent you from obtaining a
Plan benefit or exercising your rights under ERISA. If your claim for a Plan
benefit is denied in whole or in part, you must receive a written explanation of
the reason for the denial. You have the right to have the Plan review and
reconsider your claim.

        Under ERISA, there are steps you can take to enforce the above rights.
For instance, if you request materials from the Plan and do not receive them
within 30 days, you may file suit in a federal court. In such a case, the court
may require the Plan Administrator to provide the materials and pay you up to
$100 a day until you receive the materials, unless the materials were not sent
because of reasons beyond the control of the Plan Administrator. If you have a
claim for benefits that is denied or ignored, in whole or in part, you may file
suit in a state or federal court. If it should happen that the Plan fiduciaries
misuse the Plan's money, or if you are discriminated against for asserting your
rights, you may seek assistance from the U.S. Department of Labor, or you may
file suit in a federal court. The court will decide who should pay court costs
and legal fees. If you are successful, the court may order the person you have
sued to pay these costs and fees. If you lose, the court may order you to pay
these costs and fees, for example, if it finds your claim is frivolous.

        If you have any questions about this statement or about your rights
under ERISA, you should contact the nearest office of the Pension and Welfare
Benefits Administration, U.S. Department of Labor, listed in your telephone
directory, or the Division of Technical Assistance and Inquiries, Pension and
Welfare Benefit Administration, U.S. Department of Labor, 200 Constitution
Avenue N.W., Washington, D.C. 20210.

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Exhibit A:  Release (Individual Termination)
Exhibit B:  Release (Group Termination)

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                                    EXHIBIT A

                                     RELEASE
                            (INDIVIDUAL TERMINATION)

        Certain capitalized terms used in this Release are defined in the Amylin
Pharmaceuticals, Inc. Change in Control Employee Severance Benefit Plan (the
"Plan") which I have reviewed.

        I hereby confirm my obligations under the Company's proprietary
information and inventions agreement.

        I acknowledge that I have read and understand Section 1542 of the
California Civil Code which reads as follows: "A GENERAL RELEASE DOES NOT EXTEND
TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR SUSPECT TO EXIST IN HIS FAVOR AT
THE TIME OF EXECUTING THE RELEASE, WHICH IF KNOWN BY HIM MUST HAVE MATERIALLY
AFFECTED HIS SETTLEMENT WITH THE DEBTOR." I hereby expressly waive and
relinquish all rights and benefits under that section and any law of any
jurisdiction of similar effect with respect to my release of any claims I may
have against the Company.

        Except as otherwise set forth in this Release, I hereby release, acquit
and forever discharge the Company, its parents and subsidiaries, and their
officers, directors, agents, servants, employees, shareholders, successors,
assigns and affiliates, of and from any and all claims, liabilities, demands,
causes of action, costs, expenses, attorneys fees, damages, indemnities and
obligations of every kind and nature, in law, equity, or otherwise, known and
unknown, suspected and unsuspected, disclosed and undisclosed (other than any
claim for indemnification I may have as a result of any third party action
against me based on my employment with the Company), arising out of or in any
way related to agreements, events, acts or conduct at any time prior to the date
I execute this Release, including, but not limited to: all such claims and
demands directly or indirectly arising out of or in any way connected with my
employment with the Company or the termination of that employment, including but
not limited to, claims of intentional and negligent infliction of emotional
distress, any and all tort claims for personal injury, claims or demands related
to salary, bonuses, commissions, stock, stock options, or any other ownership
interests in the Company, vacation pay, fringe benefits, expense reimbursements,
severance pay, or any other form of disputed compensation; claims pursuant to
any federal, state or local law or cause of action including, but not limited
to, the federal Civil Rights Act of 1964, as amended; the federal Age
Discrimination in Employment Act of 1967, as amended ("ADEA"); the federal
Employee Retirement Income Security Act of 1974, as amended; the federal
Americans with Disabilities Act of 1990; the federal Worker Adjustment and
Retraining Notification Act of 1988; the California Fair Employment and Housing
Act, as amended; tort law; contract law; statutory law; common law; wrongful
discharge; discrimination; fraud; defamation; emotional distress; and breach of
the implied covenant of good faith and fair dealing; provided, however, that
nothing in this paragraph shall be construed in any way to release the Company
from its obligation to indemnify me pursuant to the Company's indemnification
obligation pursuant to agreement or applicable law.

        I acknowledge that I am knowingly and voluntarily waiving and releasing
any rights I may have under ADEA. I also acknowledge that the consideration
given under the Agreement

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for the waiver and release in the preceding paragraph hereof is in addition to
anything of value to which I was already entitled. I further acknowledge that I
have been advised by this writing, as required by the ADEA, that: (A) my waiver
and release do not apply to any rights or claims that may arise on or after the
date I execute this Release; (B) I have the right to consult with an attorney
prior to executing this Release; (C) I have twenty-one (21) days to consider
this Release (although I may choose to voluntarily execute this Release
earlier); (D) I have seven (7) days following the execution of this Release by
the parties to revoke the Release; and (E) this Release shall not be effective
until the date upon which the revocation period has expired, which shall be the
eighth day after this Release is executed by me.

                                        [NAME OF EMPLOYEE]

Date: ______________________            ______________________________________

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                                    EXHIBIT B

                                     RELEASE
                               (GROUP TERMINATION)

        Certain capitalized terms used in this Release are defined in the Amylin
Pharmaceuticals, Inc. Change in Control Employee Severance Benefit Plan (the
"Plan") which I have reviewed.

        I hereby confirm my obligations under the Company's proprietary
information and inventions agreement.

        I acknowledge that I have read and understand Section 1542 of the
California Civil Code which reads as follows: "A GENERAL RELEASE DOES NOT EXTEND
TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR SUSPECT TO EXIST IN HIS FAVOR AT
THE TIME OF EXECUTING THE RELEASE, WHICH IF KNOWN BY HIM MUST HAVE MATERIALLY
AFFECTED HIS SETTLEMENT WITH THE DEBTOR." I hereby expressly waive and
relinquish all rights and benefits under that section and any law of any
jurisdiction of similar effect with respect to my release of any claims I may
have against the Company.

        Except as otherwise set forth in this Release, I hereby release, acquit
and forever discharge the Company, its parents and subsidiaries, and their
officers, directors, agents, servants, employees, shareholders, successors,
assigns and affiliates, of and from any and all claims, liabilities, demands,
causes of action, costs, expenses, attorneys fees, damages, indemnities and
obligations of every kind and nature, in law, equity, or otherwise, known and
unknown, suspected and unsuspected, disclosed and undisclosed (other than any
claim for indemnification I may have as a result of any third party action
against me based on my employment with the Company), arising out of or in any
way related to agreements, events, acts or conduct at any time prior to the date
I execute this Release, including, but not limited to: all such claims and
demands directly or indirectly arising out of or in any way connected with my
employment with the Company or the termination of that employment, including but
not limited to, claims of intentional and negligent infliction of emotional
distress, any and all tort claims for personal injury, claims or demands related
to salary, bonuses, commissions, stock, stock options, or any other ownership
interests in the Company, vacation pay, fringe benefits, expense reimbursements,
severance pay, or any other form of disputed compensation; claims pursuant to
any federal, state or local law or cause of action including, but not limited
to, the federal Civil Rights Act of 1964, as amended; the federal Age
Discrimination in Employment Act of 1967, as amended ("ADEA"); the federal
Employee Retirement Income Security Act of 1974, as amended; the federal
Americans with Disabilities Act of 1990; the federal Worker Adjustment and
Retraining Notification Act of 1988; the California Fair Employment and Housing
Act, as amended; tort law; contract law; statutory law; common law; wrongful
discharge; discrimination; fraud; defamation; emotional distress; and breach of
the implied covenant of good faith and fair dealing; provided, however, that
nothing in this paragraph shall be construed in any way to release the Company
from its obligation to indemnify me pursuant to the Company's indemnification
obligation pursuant to agreement or applicable law.

        I acknowledge that I am knowingly and voluntarily waiving and releasing
any rights I may have under ADEA. I also acknowledge that the consideration
given under the Agreement

                                       1.
<PAGE>   14

for the waiver and release in the preceding paragraph hereof is in addition to
anything of value to which I was already entitled. I further acknowledge that I
have been advised by this writing, as required by the ADEA, that: (A) my waiver
and release do not apply to any rights or claims that may arise on or after the
date I execute this Release; (B) I have the right to consult with an attorney
prior to executing this Release; (C) I have forty-five (45) days to consider
this Release (although I may choose to voluntarily execute this Release
earlier); (D) I have seven (7) days following the execution of this Release by
the parties to revoke the Release; (E) this Release shall not be effective until
the date upon which the revocation period has expired, which shall be the eighth
day after this Release is executed by me; and (F) I have received with this
Release a detailed list of the job titles and ages of all employees who were
terminated in this group termination and the ages of all employees of all
employees in the same job classification or organizational unit who were not
terminated.

                                        [NAME OF EMPLOYEE]

Date: _____________________             _____________________________________

                                       2<PAGE>   1
                                                                   EXHIBIT 10.45

                          AMYLIN PHARMACEUTICALS, INC.

                         2001 DEFERRED COMPENSATION PLAN

                             EFFECTIVE APRIL 1, 2001

<PAGE>   2

                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                                          PAGE
<S>            <C>                                                                        <C>
SECTION 1         DEFINITIONS................................................................1

        1.1    "Account".....................................................................1

        1.2    "Base Salary".................................................................1

        1.3    "Beneficiary".................................................................1

        1.4    "Cash Bonus"..................................................................2

        1.5    "Change in Control"...........................................................2

        1.6    "Code"........................................................................2

        1.7    "Consultant...................................................................2

        1.8    "Consulting Fees..............................................................2

        1.9    "Committee"...................................................................2

        1.10   "Compensation"................................................................2

        1.11   "Directors Fees"..............................................................3

        1.12   "Effective Date"..............................................................3

        1.13   "Eligible Compensation".......................................................3

        1.14   "Employee"....................................................................3

        1.15   "Employer"....................................................................3

        1.16   "Employer Contributions"......................................................3

        1.17   "Hardship"....................................................................3

        1.18   "Non-Employee Director".......................................................3

        1.19   "Plan Year"...................................................................3

        1.20   "Plan"........................................................................3

        1.21   "Permanent Disability"........................................................3

        1.22   "Service".....................................................................3

        1.23   "Service Provider"............................................................4

        1.24   "Subsidiary"..................................................................4

        1.25   "Transferee Plan".............................................................4

        1.26   "Trust" or "Trust Agreement"..................................................4

        1.27   "Trust Fund"..................................................................4

        1.28   "Trustee".....................................................................4

SECTION 2         ELIGIBILITY................................................................4
</TABLE>

                                       i
<PAGE>   3

                                TABLE OF CONTENTS
                                   (CONTINUED)

<TABLE>
<CAPTION>
                                                                                          PAGE
<S>            <C>                                                                        <C>
        2.1    Eligibility...................................................................4

SECTION 3         DEFERRED COMPENSATION......................................................4

        3.1    Deferred Compensation.........................................................4

        3.2    Payment of Account Balances...................................................6

        3.3    Election to Defer Compensation................................................7

        3.4    Distribution Election.........................................................7

        3.5    Hardship......................................................................8

        3.6    Service Provider's Right Unsecured............................................9

        3.7    Investment of Contribution....................................................9

        3.8    Distribution with Penalty.....................................................9

SECTION 4         DESIGNATION OF BENEFICIARY................................................10

        4.1    Designation of Beneficiary...................................................10

SECTION 5         TRUST PROVISIONS..........................................................10

        5.1    Trust Agreement..............................................................10

SECTION 6         AMENDMENT, TERMINATION AND TRANSFERS BY COMMITTEE.........................10

        6.1    Amendment....................................................................10

        6.2    Termination..................................................................11

        6.3    Transfers by Committee.......................................................11

SECTION 7         ADMINISTRATION............................................................11

        7.1    Administration...............................................................11

        7.2    Liability of Committee; Indemnification......................................11

        7.3    Expenses.....................................................................11

SECTION 8         GENERAL AND MISCELLANEOUS.................................................12

        8.1    Rights against Employer......................................................12

        8.2    Assignment or Transfer.......................................................12

        8.3    Severability.................................................................12

        8.4    Construction.................................................................12

        8.5    Governing Law................................................................12

        8.6    Payment Due to Incompetence..................................................12
</TABLE>

                                       ii
<PAGE>   4

                                TABLE OF CONTENTS
                                   (CONTINUED)

<TABLE>
<CAPTION>
                                                                                          PAGE
<S>            <C>                                                                        <C>
        8.7    Tax..........................................................................13

        8.8    Attorney's Fees..............................................................13

        8.9    Plan Binding on Successors/Assignees.........................................13
</TABLE>

                                      iii

<PAGE>   5

                          AMYLIN PHARMACEUTICALS, INC.
                         2001 DEFERRED COMPENSATION PLAN
                             EFFECTIVE APRIL 1, 2001

        AMYLIN PHARMACEUTICALS, INC., a Delaware Corporation (referred to
hereafter as the "Employer") established, effective April 1, 2001, the Amylin
Pharmaceuticals, Inc. 2001 Deferred Compensation Plan (the "Plan"), an unfunded
plan for the purpose of providing deferred compensation for a select group of
management and highly compensated executives and other persons as described
herein.

                                    RECITALS

        WHEREAS, those persons identified by the Board of Directors of the
Employer, the Compensation Committee of the Board of Directors of the Employer
or any other committee designated by the Board of Directors of the Employer to
administer this Plan in accordance with Section 8 hereof (hereinafter referred
to as the "Committee") as eligible to participate in this Plan (each of whom are
referred to hereafter as a "Service Provider" or collectively as the "Service
Providers");

        WHEREAS, Employer desires to adopt an unfunded deferred compensation
plan and the Service Providers desire the Employer to pay certain deferred
compensation and/or related benefits to or for the benefit of Service Providers,
or a designated Beneficiary or both; and

        WHEREAS, Employer believes it is in the best interest of Service
Providers and their Beneficiaries to adopt the Plan;

        NOW, THEREFORE, the Employer hereby adopts the Plan effective as of
April 1, 2001.

                                    SECTION 1

                                   DEFINITIONS

        1.1    "Account" shall mean the separate account(s) established under
this Plan and the Trust for each participating Service Provider.

        1.2    "Base Salary" shall mean, for a given semi-annual period, an
Employee's regular compensation payable during the semi-annual period, excluding
bonuses, commissions, overtime, incentive payments, non-monetary awards,
compensation deferred pursuant to all Section 125 (cafeteria) or Section 401(k)
(savings) plans of the Employer and other special compensation, and reduced by
the tax withholding obligations imposed on the Employer and any other
withholding requirements imposed by law with respect to such amounts.

        1.3    "Beneficiary" or "Beneficiaries" shall mean a person or persons
designated by the Service Provider to receive such Service Provider's deferred
compensation benefits in the event of his or her death.

                                       1.
<PAGE>   6

        1.4    "Cash Bonus" shall mean amounts (if any) awarded under the bonus
policies maintained by the Employer and any commissions earned on sales.

        1.5    "Change in Control" shall mean the happening of any of the
following:

               (a)    any "person," as such term is used in Sections 13(d) and
14(d) of the Securities and Exchange Act of 1934, as amended from time to time,
and any successor statute (the "Exchange Act") (other than the Employer, a
subsidiary, an affiliate, or an Employer employee benefit plan, including any
trustee of such plan acting as trustee) is or becomes the "beneficial owner" (as
defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of
securities of the Employer representing 50% or more of the combined voting power
of the Employer's then outstanding securities other than by virtue of a merger,
consolidation or similar transaction;

               (b)    there is consummated a sale or other disposition of all or
substantially of assets of the Employer (other than a sale to an entity where at
least 50% of the combined voting power of the voting securities of such entity
are owned by the stockholders of the Employer in substantially the same
proportions as their ownership of the Employer immediately prior to such sale);

               (c)    there is consummated a merger, consolidation or similar
transaction involving the Employer and, immediately after the consummation of
such transaction, the stockholders of Employer immediately prior to the
consummation of such transaction do not own, directly or indirectly, outstanding
voting securities representing more than 50% of the combined outstanding voting
power of the surviving entity in such transaction or more than 50% of the
combined outstanding voting power of the parent of the surviving entity in such
transaction.

        1.6    "Code" shall mean the Internal Revenue Code of 1986, as amended
from time to time, and the rules and regulations promulgated thereunder.

        1.7    "Consultant" shall mean a person who: (i) is providing consulting
services to the Employer, (ii) was previously employed by the Employer as an
officer, vice-president, or equivalent title and (iii) was identified by the
Committee as eligible to participate in this Plan while employed by the
Employer.

        1.8    "Consulting Fees" shall mean, for a given semi-annual period, the
consulting fees payable to a Consultant by the Employer during the semi-annual
period.

        1.9    "Committee" shall mean the Compensation Committee of the Board of
Directors of the Employer or any other committee designated by the Board of
Directors of the Employer to administer this Plan in accordance with Section 7
hereof.

        1.10   "Compensation" shall mean the Base Salary, Cash Bonuses,
Consulting Fees and Director Fees as defined herein.

                                       2.
<PAGE>   7

        1.11   "Directors Fees" shall mean, for a given semi-annual period, the
retainer, per meeting fees, committee meeting fees, and consulting fees payable
to a Non-Employee Director by the Employer during the semi-annual period.

        1.12   "Effective Date" of the Plan shall mean April 1, 2001.

        1.13   "Eligible Compensation" shall mean projected annual compensation
from the Employer determined on an annual basis by the Employer at or before the
beginning of the Plan, which may consist of salary, bonus, and/or incentive
payments, determined before any deductions under any qualified plan of the
Employer (including a Section 401(k) plan or a Section 125 plan) and excluding
any special or non-recurring compensatory payments such as moving or relocation
bonuses or automobile allowances.

        1.14   "Employee" shall mean each employee of Employer.

        1.15   "Employer" shall mean Amylin Pharmaceuticals, Inc., a Delaware
corporation, and any successor organization thereto, and any Subsidiary of the
Company.

        1.16   "Employer Contributions" shall mean the Employer's discretionary
contribution, if any, pursuant to Section 3.1(b) of the Plan.

        1.17   "Hardship" shall have the meaning set forth in Section 3.5 of the
Plan.

        1.18   "Non-Employee Director" shall mean a director of the Employer who
is not otherwise an Employee of the Employer.

        1.19   "Plan Year" shall mean the year beginning each January 1 and
ending December 31; notwithstanding the foregoing, the initial Plan Year shall
mean the period beginning with the Effective Date and ending on December 31,
2001.

        1.20   "Plan" shall mean the Amylin Pharmaceuticals, Inc. 2001 Deferred
Compensation Plan, including any amendments thereto.

        1.21   "Permanent Disability" shall mean that the Service Provider is
unable to engage in any substantial gainful activity by reason of any medically
determinable physical or mental impairment that can be expected to result in
death or otherwise meets the definition of "Permanent Disability" as set forth
in the Employer's Long Term Disability Plan as in effect on the date of such
determination. A Service Provider will not be considered to have a Permanent
Disability unless he or she furnishes proof of such condition sufficient to
satisfy the Employer, in its sole discretion.

        1.22   "Service" shall mean employment as a common law employee, service
as a Consultant or service as a Non-Employee Director of the Employer, as
applicable. An Employee shall not be deemed to terminate Service if the Employee
converts from a Non-Employee Director to a common law employee from a common law
employee to a Consultant or any combination thereof.

                                       3.
<PAGE>   8

        1.23   "Service Provider" shall mean an Employee, Non-Employee Director
and Consultant of the Employer, and a Service Provider's Beneficiary where the
context so requires.

        1.24   "Subsidiary" shall mean any corporation (other than the Employer)
in an unbroken chain of corporations beginning with the Employer, if each of the
corporations other than the last corporation in the unbroken chain owns stock
possessing fifty (50) percent or more of the total combined voting power of all
classes of stock in one of the other corporations in such chain.

        1.25   "Transferee Plan" shall mean an unfunded, nonqualified deferred
compensation plan described in Section 201(2), 301(a)(3) and 401(a)(1) of the
Employee Retirement Income Security Act of 1974 ("ERISA").

        1.26   "Trust" or "Trust Agreement" shall mean the Amylin
Pharmaceuticals, Inc. 2001 Deferred Compensation Plan Rabbi Trust Agreement,
including any amendments thereto, entered into between the Employer and the
Trustee to carry out the provisions of the Plan.

        1.27   "Trust Fund" shall mean the cash and other assets and/or
properties held and administered by Trustee pursuant to the Trust to carry out
the provisions of the Plan.

        1.28   "Trustee" shall mean the designated Trustee acting at any time
under the Trust.

                                    SECTION 2

                                   ELIGIBILITY

        2.1 ELIGIBILITY. Eligibility to participate in the Plan shall be limited
to Service Providers of the Employer who: (1) (a) are (or were) classified as
officers, vice-presidents, or an equivalent title, and (b) have been selected by
the Committee to participate in the Plan, or (2) are Non-Employee Directors. The
Committee shall designate Service Providers who shall be covered by this Plan in
a separate Acknowledgment (in the form attached hereto as Appendix 1) for each
such Service Provider. Participation in the Plan shall commence as of the date
such Acknowledgment is signed by the Service Provider and delivered to the
Employer, provided that deferral of Compensation under the Plan shall not
commence until the Service Provider has complied with the election procedures
set forth in Section 3.3. Nothing in the Plan or in the Acknowledgment should be
construed to require any contributions to the Plan on behalf of the Service
Provider by Employer.

                                    SECTION 3

                              DEFERRED COMPENSATION

        3.1    DEFERRED COMPENSATION.

               (a)    Each participating Service Provider may elect, in
accordance with Section 3.3 of this Plan, to defer semi-annually the receipt of
all or a portion of the Compensation for active Service otherwise payable to him
or her by Employer during each semi-annual period or portion of a semi-annual
period during the Service Provider's Service to the Employer. Any

                                       4.
<PAGE>   9

Compensation deferred by Service Provider pursuant to Section 3.3 shall be
recorded by the Employer in an Account, maintained in the name of the Service
Provider, which Account shall be credited with a dollar amount equal to the
total amount of Compensation deferred during each semi-annual period under the
Plan, together with earnings thereon credited in accordance with Section 3.7.
The amount or percentage of Compensation that Service Provider elects to defer
under Section 3.3 will remain constant for the semi-annual period and shall not
be subject to change during such semi-annual period. Each such deferral election
by a Non-Employee Director as to Directors Fees or discontinuance of a deferral
election as to Directors Fees will continue in force for each successive
semi-annual period until or unless suspended or modified by the filing of a
subsequent election with the Employer by the Non-Employee Director in accordance
with Section 3.3 of the Plan. Each deferral election as to an Employee's Base
Compensation or a Consultant's Consulting Fees shall continue in force only for
the semi-annual period to which such election applies, and shall not apply to
any successive semi-annual periods. Each deferral election as to an Employee's
Cash Bonus shall continue in force only for the single semi-annual period in
which it is paid, regardless of the period of time as to which it is awarded,
and shall not apply to any successive semi-annual periods. Any deferral election
with respect to a Cash Bonus must be made prior to the time the amount of the
bonus is determined, prior to the end of the period of time as to which the
bonus is awarded, and at a time that the amount of any such bonus remains
substantially uncertain. All deferrals pursuant to this Section 3.1 shall be
fully vested at all times. Deferral elections shall be subject to a minimum
dollar and maximum percentage amounts as follows: (i) the minimum semi-annual
deferral amount is $2,500, which shall be withheld from the Employee's
Compensation, and (ii) the maximum deferral percentage amounts for each Plan
Year shall be determined by the Committee prior to the commencement of such Plan
Year; but in no event shall the maximum deferral percentage exceed the maximum
amount of the Employee's Base Salary which may be deferred under applicable
federal and state labor and employment laws (including wage and hour laws), 100%
of the Employee's Cash Bonus, 100% of the Consultant's Consulting Fees and 100%
of the Non-Employee Director's Directors Fees.

               (b)    Employer shall not be obligated to make any other
contribution to the Plan on behalf of any Service Provider at any time. Employer
may make Employer Contributions to the Plan on behalf of one or more Service
Providers. Employer Contributions, if any, made to Accounts of Service Providers
shall be determined in the sole and absolute discretion of the Employer, and may
be made without regard to whether the Service Provider to whose Account such
contribution is credited has made, or is making, contributions pursuant to
Section 3.1(a). The Employer shall not be bound or obligated to apply any
specific formula or basis for calculating the amount of any Employer
Contributions and Employer shall have sole and absolute discretion as to the
allocation of Employer Contributions among participating Service Provider
Accounts. The use of any particular formula or basis for making an Employer
Contribution in one year shall not bind or obligate the Employer to use such
formula or basis in any other year. Employer Contributions may be subject to a
substantial risk of forfeiture in accordance with the terms of a vesting
schedule, which may be selected by the Employer in its sole and absolute
discretion.

               (c)    Amounts deferred under the Plan shall be calculated and
withheld from the Employee's base salary and/or cash bonus after such
compensation has been reduced to reflect salary reduction contributions to the
Employer's Code Section 125 (cafeteria) and Code

                                       5.
<PAGE>   10

Section 401(k) (savings) plans, and after any reductions for contributions to
the Code Section 423 (employee stock purchase) plan.

        3.2    PAYMENT OF ACCOUNT BALANCES.

               (a)    The Service Provider shall elect whether he or she will
receive distribution of his or her entire Account, subject to tax withholding
requirements, (i) upon reaching a specified age, (ii) upon passage of a
specified number of years, (iii) upon a Change in Control (iv) upon termination
of Service with Employer, (v) upon the earlier to occur of (A) termination of
Service with Employer (B) passage of a specified number of years or attainment
of a specified age, or (C) upon a Change in Control (vi) upon the later to occur
of (A) termination of Service with Employer (B) passage of a specified number of
years or attainment of a specified age or (C) upon a Change in Control, as
elected by Service Provider in accordance with the form established by the
Committee. Such form may permit an election among some or all of the
alternatives listed in this Section 3.2(a), as determined in the Committee's
sole discretion. A designation of the time of distribution shall be required as
a condition of participation under this Plan. The Service Provider shall also
elect to receive all amounts payable to him or her in a lump sum or in equal
monthly installments over a designated period of five or ten years, pursuant to
the provisions of Section 3.2(e). These elections shall be made in accordance
with Section 3.4 of this Plan.

               (b)    Distributions shall be made to the maximum extent
allowable under the election made by Service Provider, except that no
distribution shall be made to the extent that the receipt of such distribution,
when combined with the receipt of all other "applicable employee remuneration"
(as defined in Code Section 162(m)(4)) would cause any remuneration received by
an Employee to be nondeductible by the Employer under Code Section 162(m)(1).
The portion of any distributable amount that is not distributed by operation of
this Section 3.2(b) shall be distributed in subsequent years in the manner
elected by the Service Provider until the Service Provider's Account has been
fully liquidated. The commencement date of the lump sum payment or the five- or
ten-year period (whichever is applicable) shall be automatically extended, when
necessary to satisfy the requirements of this subsection, for one-year periods
until all Account balances have been distributed in the manner elected by the
Service Provider.

               (c)    Upon termination of Service Provider's Service with
Employer by reason of death or Permanent Disability prior to the time when
payment of Account balances otherwise would commence under the provisions of
Section 3.2(a), Service Provider or Service Provider's designated Beneficiary
will be entitled to receive all amounts credited to the Account of Service
Provider as of the date of his or her death or Permanent Disability
(notwithstanding any contrary election to receive distributions under the first
sentence of Section 3.2(a)). Upon termination of Service Provider's Service with
Employer by reason other than death or Permanent Disability prior to the date
when payment of Account balances otherwise would commence under the provisions
of Section 3.2(a), the Employer may, in the sole discretion of the Committee,
distribute to Service Provider or Service Provider's designated Beneficiary all
amounts credited to the Service Provider's Account as of the date of such
termination (notwithstanding any contrary election to receive distributions
under the first sentence of Section 3.2(a)). Said amounts shall be payable in
the form determined pursuant to the provisions of Section 3.2(e).

                                       6.
<PAGE>   11

               (d)    Upon the death of Service Provider prior to complete
distribution to him or her of the entire balance of his or her Account (and
after the date of termination of employment with Employer), the balance of his
or her Account on the date of death shall be payable to Service Provider's
designated Beneficiary pursuant to Section 3.2(e). Notwithstanding any other
provision of the Plan to the contrary, the Service Provider's designated
Beneficiary may receive the distribution of the remaining portion of such
deceased Service Provider's Account in the form of a lump sum if the Beneficiary
requests such a distribution and the Committee, in its sole discretion, consents
to such a distribution.

               (e)    The Employer shall distribute or direct distribution of
the balance of amounts previously credited to Service Provider's Account, in a
lump sum, or in monthly installments over a period of five (5) years or ten (10)
years as Service Provider shall designate. A designation of the form of
distribution shall be required as a condition of participation under this Plan.
Distribution of the lump sum or the first installment shall be made or commence
within ninety (90) days following the date specified in the first sentence of
Section 3.2(a), or as otherwise provided in 3.2(c). Subsequent installments, if
any, shall be made on the first day of each month following the last installment
as determined by Employer. The amount of each installment shall be calculated by
dividing the Account balance as of the date of the distribution by the number of
installments remaining pursuant to the Service Provider's distribution election.
Each such installment, if any, shall take into account earnings credited to the
balance of the Account remaining unpaid. The Service Provider's distribution
election shall be made on a form provided by Employer.

        3.3    ELECTION TO DEFER COMPENSATION. Each election of a Service
Provider to defer compensation as provided in Section 3.1 of this Plan shall be
in writing, signed by the Service Provider, and delivered to Employer, together
with all other documents required under the provisions of this Plan, within such
time as determined by the Committee and communicated to those Service Providers
who are eligible to participate in the Plan; provided, however, that such
deferral elections must be delivered to Employer at least three (3) months prior
to the beginning of the semi-annual period during each Plan Year with respect to
which the Compensation to be deferred is otherwise payable to Service Provider;
provided, further, that for the Plan Year in which this Plan is first
implemented, and in the case of an Employee who is hired or promoted to a
position of eligibility for participation in the Plan or a Non-Employee Director
who is elected to become a Non-Employee Director during a semi-annual period,
such Service Provider shall have thirty (30) days from the date of notification
of eligibility for participation in the Plan in which to submit the required
election documents for the then current semi-annual period. Any deferral
election made by Service Provider shall be irrevocable with respect to any
Compensation covered by such election, including Compensation payable in the
semi-annual period in which the election suspending or modifying the prior
deferral election is delivered to Employer. The Employer shall withhold the
amount or percentage of Base Salary specified to be deferred in equal amounts
for each payroll period and shall withhold the amount or percentage of each Cash
Bonus specified to be deferred at the time or times such Cash Bonus is or
otherwise would be paid to the Employee. The election to defer Compensation
shall be made on the form provided by Employer. The Employer shall withhold the
amount or percentage of Consulting Fees and/or Directors Fees specified to be
deferred at the time or times such Consulting Fees and/or Directors Fees are or
otherwise would be paid to the Service Provider.

                                       7.
<PAGE>   12

        3.4    DISTRIBUTION ELECTION. The initial distribution election of a
Service Provider as provided in Section 3.2 of this Plan shall be in writing,
signed by the Service Provider, and delivered to Employer, together with all
other documents required under the provisions of this Plan, within such period
of time determined by the Committee and communicated to those Service Providers
who are eligible to participate in the Plan. Such distribution elections must be
delivered to the Employer prior to the beginning of the first Plan Year in which
Service Provider is eligible to participate in the Plan; provided however, that
a Service Provider who is hired or promoted to a position of eligibility for
participation in the Plan or a Non-Employee Director who is elected to become a
Non-Employee Director during a Plan Year shall have thirty (30) days from the
date of notification of eligibility for participation in the Plan in which to
submit the required distribution election documents. If permitted by the
Committee, a Service Provider may change the terms of his or her initial
distribution election by making a new election, and any such new election will
be effective as of the date that is twenty-five (25) months following the date
the new election is made and such new election will apply to the Service
Provider's entire account. A Service Provider may not make a new election once
distributions from the Plan have commenced or which would first become effective
at a time when distributions from the Plan have commenced. A Service Provider's
distribution election shall be in the form established by the Committee in
accordance with the terms of the Plan.

        3.5    HARDSHIP.

               (a)    A Service Provider may apply for distributions from his or
her Account to the extent that the Service Provider demonstrates to the
reasonable satisfaction of the Committee that he or she needs the funds due to
Hardship. For purposes of this Section 3.5, a distribution is made on account of
"Hardship" only if the distribution is made on account of an unforeseeable
immediate and heavy emergency financial need of the Service Provider and is
necessary to satisfy that emergency financial need. Whether a Service Provider
has an immediate and heavy emergency financial need shall be determined by the
Committee based on all relevant facts and circumstances, and shall include, but
not be limited to: the need to pay funeral expenses of a family member; the need
to pay expenses for medical care for Service Provider, the Service Provider's
spouse or any dependent of Service Provider resulting from sudden unexpected
illness or accident; payments necessary to prevent the eviction of Service
Provider from Service Provider's principal residence or foreclosure on the
mortgage on that residence; or other similar extraordinary and unforeseeable
circumstances arising as a result of events beyond the control of Service
Provider. A Hardship distribution shall not exceed the amount required to
relieve the financial need of the Service Provider, nor shall a Hardship
distribution be made if the need may be satisfied from other resources
reasonably available to the Service Provider. For purposes of this paragraph, a
Service Provider's resources shall be deemed to include those assets of the
Service Provider's spouse and minor children that are reasonably available to
the Service Provider. Prior to approving a Hardship distribution, Employer shall
require the Service Provider to certify in writing that the Service Provider's
financial need cannot reasonably be relieved:

                      (i)    through reimbursement or compensation by insurance
or otherwise; or

                                       8.
<PAGE>   13

                      (ii)   by other distributions or nontaxable (at the time
of the loan) loans from plans maintained by the Employer or by any other
employer, or by borrowing from commercial sources on reasonable commercial
terms, in an amount sufficient to satisfy the need.

               (b)    Any Service Provider receiving a Hardship distribution
under this section shall be ineligible to defer any additional Compensation
under the Plan until the first day of the Plan Year following the second
anniversary of the date of the Hardship distribution. In addition, a new
deferred election must be submitted to the Employer as a condition of
participation in the Plan.

        3.6    SERVICE PROVIDER'S RIGHT UNSECURED. The right of the Service
Provider or his or her designated Beneficiary to receive a distribution
hereunder shall be an unsecured claim against the general assets of the
Employer, and neither the Service Provider nor his or her designated Beneficiary
shall have any rights in or against any amount credited to his or her Account or
any other specific assets of the Employer, except as otherwise provided in the
Trust. Nothing contained in this Plan, and no action taken pursuant to its
provisions, shall create or be construed to create a trust of any kind or a
fiduciary relationship between the Plan and the Employer or any other person.

        3.7    INVESTMENT OF CONTRIBUTION.

               (a)    The investment options available to each Service Provider
shall be determined by the Employer and set forth in a separate written document
or in a manner acceptable to the Committee, a copy of which shall be attached
hereto and by this reference is incorporated herein. Each Service Provider shall
have the sole and exclusive right to direct the Trustee as to the investment of
his or her Accounts in accordance with policies and procedures implemented by
the Trustee. The right of a Service Provider to direct the investment of his or
her Account into one or more of the available investment options shall not in
any way be considered to alter the fact that an Account is a bookkeeping account
only that measures the Employer's obligation to pay benefits hereunder, that the
assets being invested at the direction of a Service Provider are assets of the
Employer and that the Service Provider's rights under the Plan remain those of
an unsecured, general creditor of the Employer. Employer shall not be liable for
any investment decision made by any Service Provider while such funds are held
by the Trustee.

               (b)    Accounts shall be credited with the actual financial
performance or earnings generated by such investments directed by the Service
Provider and made by the Trustee, until the Account has been fully distributed
to the Service Provider or to the Service Provider's designated Beneficiary.

               (c)    Employer shall furnish each participant with a statement
of his or her account balance at least annually.

        3.8    DISTRIBUTION WITH PENALTY. Notwithstanding the foregoing, a
Service Provider may elect to receive a distribution of his or her Account at
any time, upon ten (10) days' notice to Employer; provided that upon such
distribution ten percent (10%) of such Service Provider's Account shall be
forfeited to Employer and may not be recontributed by Employer to Service

                                       9.
<PAGE>   14

Provider's Account; provided further that a Service Provider receiving a
distribution under this Section shall be ineligible to defer any additional
Compensation under the Plan until the first day of the Plan Year following the
date of such distribution. In addition a new deferral election must be submitted
to Employer as a condition of participation in the Plan.

                                   SECTION 4

                           DESIGNATION OF BENEFICIARY

        4.1    DESIGNATION OF BENEFICIARY. Service Provider may designate a
Beneficiary or Beneficiaries to receive any amount due hereunder by Service
Provider by written notice thereof to Employer at any time prior to Service
Provider's death and may revoke or change the Beneficiary designated therein
without the Beneficiary's consent by written notice delivered to Employer at any
time and from time to time prior to Service Provider's death. If Service
Provider is married and a resident of a community property state, one half of
any amount due hereunder which is the result of an amount contributed to the
Plan during such marriage is the community property of the Service Provider's
spouse and Service Provider may designate a Beneficiary or Beneficiaries to
receive only the Service Provider's one-half interest. If Service Provider shall
have failed to designate a Beneficiary, or if no such Beneficiary shall survive
him or her, then such amount shall be paid to his or her estate. Designations of
Beneficiaries shall be made on the form provided by Employer.

                                   SECTION 5

                                TRUST PROVISIONS

        5.1    TRUST AGREEMENT. The Employer may establish the Trust for the
purpose of retaining assets set aside by Employer pursuant to the Trust
Agreement for payment of all or a portion of the amounts payable pursuant to the
Plan. Any benefits not paid from the Trust shall be paid solely from Employer's
general funds, and any benefits paid from the Trust shall be credited against
and reduce by a corresponding amount the Employer's liability to Service
Providers under the Plan. No special or separate fund, other than the Trust
Agreement, shall be established and no other segregation of assets shall be made
to assure the payment of any benefits hereunder. All Trust Funds shall be
subject to the claims of general creditors of the Employer in the event the
Employer is Insolvent as defined in Section 3 of the Trust Agreement. The
obligations of the Employer to pay benefits under the Plan constitute an
unfunded, unsecured promise to pay and Service Providers shall have no greater
rights than general creditors of the Employer.

                                   SECTION 6

                AMENDMENT, TERMINATION AND TRANSFERS BY COMMITTEE

        6.1    AMENDMENT. The Committee shall have the right to amend this Plan
at any time and from time to time, including a retroactive amendment. Any such
amendment shall come effective upon the date stated therein, and shall be
binding on all Service Providers, except as otherwise provided in such
amendment; provided, however, that said amendment shall not affect

                                      10.
<PAGE>   15

adversely benefits payable to an affected Service Provider without the Service
Provider's written approval.

        6.2    TERMINATION. The Committee shall have the right to terminate this
Plan at any time and direct the lump sum payments of all assets held by the
Trust if the Employer is not Insolvent (as defined in Section 3 of the Trust
Agreement) at that time.

        6.3    TRANSFERS BY COMMITTEE.

               (a)    In the event that a Service Provider transfers employment
from the Employer to a Subsidiary, the Committee shall have the right, but no
obligation, to direct the Trustee to transfer funds in an amount equal to the
amount credited to such Service Provider's Account (the "Transferred Account")
to a trust established under a Transferee Plan maintained by such Subsidiary.
The Committee shall determine, in its sole discretion, whether such transfer
shall be made and the timing of such transfer. Such transfer shall be made only
if, and to the extent, approval of such transfer is obtained from the Trustee.

               (b)    No transfer shall be made under this Section 6.3 unless
the Service Provider for whose benefit the Transferred Account is held executes
a written waiver of all of such Service Provider's rights and benefits under
this Plan in such form as shall be acceptable to the Committee.

                                   SECTION 7

                                 ADMINISTRATION

        7.1    ADMINISTRATION. The Committee shall administer and interpret this
Plan in accordance with the provisions of the Plan and the Trust Agreement. Any
determination or decision by the Committee shall be conclusive and binding on
all persons who at any time have or claim to have any interest whatever under
this Plan. The Committee may employ legal counsel, consultants, actuaries and
agents as it may deem desirable in the administration of the Plan and may rely
on the opinion of such counsel or the computations of such consultant or other
agent. The Committee shall have the authority to delegate some or all of the
powers and responsibilities under the Plan and the Trust Agreement to such
person or persons as it shall deem necessary, desirable or appropriate for
administration of the Plan.

        7.2    LIABILITY OF COMMITTEE; INDEMNIFICATION. To the maximum extent
not prohibited by law, no member of the Committee shall be liable to any person
and in any event shall be indemnified by the Employer for any action taken or
omitted in connection with the interpretation and administration of this Plan
unless attributable to his or her own bad faith or willful misconduct.

        7.3    EXPENSES. The costs of the establishment of the Plan and the
adoption of the Plan by Employer, including but not limited to legal and
accounting fees, shall be borne by Employer. The expenses of administering the
Plan and the Trust shall be borne by the Trust unless the Employer elects in its
sole discretion to pay some or all of those expenses; provided, however, that
Employer shall bear, and shall not be reimbursed by, the Trust for any tax
liability of Employer associated with the investment of assets by the Trust.

                                      11.
<PAGE>   16

                                    SECTION 8

                            GENERAL AND MISCELLANEOUS

        8.1    RIGHTS AGAINST EMPLOYER. Except as expressly provided by the
Plan, the establishment of this Plan shall not be construed as giving to any
Service Provider or to any person whomsoever, any legal, equitable or other
rights against the Employer, or against its officers, directors, agents or
shareholders, or as giving to any Service Provider or Beneficiary any equity or
other interest in the assets, business or shares of Employer stock or giving any
Service Provider the right to be retained in the employment of the Employer.
Neither this plan nor any action taken hereunder shall be construed as giving to
any Service Provider the right to be retained in the employ of the Employer or
as affecting the right of the Employer to dismiss any Service Provider. Any
benefit payable under the Plan shall not be deemed salary or other compensation
for the purpose of computing benefits under any employee benefit plan or other
arrangement of the Employer for the benefit of its Employees. Nothing in the
Plan or in any instrument executed pursuant thereto shall confer upon any
Consultant any right to continue in the service of the Employer in any capacity.
Nothing in the Plan or in any instrument executed pursuant thereto shall confer
upon any Non-Employee Director any right to continue in the service of the
Employer in any capacity or shall affect any right of the Employer, its Board of
Directors or stockholders to remove any Non-Employee Director pursuant to the
Employer's Bylaws and the provisions of the Delaware General Corporation Law.

        8.2    ASSIGNMENT OR TRANSFER. No right, title or interest of any kind
in the Plan shall be transferable or assignable by any Service Provider or
Beneficiary or be subject to alienation, anticipation, encumbrance, garnishment,
attachment, execution or levy of any kind, whether voluntary or involuntary, nor
subject to the debts, contracts, liabilities, engagements, or torts of the
Service Provider or Beneficiary. Any attempt to alienate, anticipate, encumber,
sell, transfer, assign, pledge, garnish, attach or otherwise subject to legal or
equitable process or encumber or dispose of any interest in the Plan shall be
void.

        8.3    SEVERABILITY. If any provision of this Plan shall be declared
illegal or invalid for any reason, said illegality or invalidity shall not
affect the remaining provisions of this Plan but shall be fully severable, and
this Plan shall be construed and enforced as if said illegal or invalid
provision had never been inserted herein.

        8.4    CONSTRUCTION. The article and section headings and numbers are
included only for convenience of reference and are not to be taken as limiting
or extending the meaning of any of the terms and provisions of this Plan.
Whenever appropriate, words used in the singular shall include the plural or the
plural may be read as the singular. When used herein, the masculine gender
includes the feminine gender.

        8.5    GOVERNING LAW. The validity and effect of this Plan and the
rights and obligations of all persons affected hereby shall be construed and
determined in accordance with the laws of the State of California unless
superseded by federal law.

        8.6    PAYMENT DUE TO INCOMPETENCE. If the Committee receives evidence
that a Service Provider or Beneficiary entitled to receive any payment under the
Plan is physically or

                                      12.
<PAGE>   17

mentally incompetent to receive such payment, the Committee may, in its sole and
absolute discretion, direct the payment to any other person or Trust which has
been legally appointed by the courts or to any other person determined by the
Employer to be a proper recipient on behalf of such person otherwise entitled to
payment, or any of them, in such manner and proportion as the Employer may deem
proper. Any such payment shall be in complete discharge of the Employer's
obligations under this Plan.

        8.7    TAX. The Employer may withhold from any benefits payable under
this Plan, all federal, state, city or other taxes as shall be required pursuant
to any law or governmental regulation or ruling.

        8.8    ATTORNEY'S FEES. Employer shall pay the reasonable attorney's
fees incurred by any Service Provider in an action brought against Employer to
enforce Service Provider's rights under the Plan, provided that such fees shall
only be payable in the event that the Service Provider prevails in. such action.

        8.9    PLAN BINDING ON SUCCESSORS/ASSIGNEES. This Plan shall be binding
upon and inure to the benefit of the Employer and its successor and assigns and
the Service Provider and the Service Provider's designee and estate.

        The Employer has caused its authorized officer to execute this Plan this
____ day of March, 2001.

                                         AMYLIN PHARMACEUTICALS, INC.

                                         By: ___________________________________
                                                Joseph C. Cook, Jr.
                                                Chief Executive Officer and
                                                Chairman of the Board

                                      13.
<PAGE>   18

                                   APPENDIX 1

                                 ACKNOWLEDGMENT

        The undersigned Service Provider hereby acknowledges that Employer has
selected him or her as a participant in the Amylin Pharmaceuticals, Inc. 2001
Deferred Compensation Plan, subject to all terms and conditions of the Plan, a
copy of which has been received, read, and understood by the Service Provider in
conjunction with executing this Acknowledgment. Service Provider acknowledges
that he or she has had satisfactory opportunity to ask questions regarding his
or her participation in the Plan and has received satisfactory answers to any
questions asked. Service Provider also acknowledges that he or she has
sufficient knowledge and experience in financial and business matters to be
capable of evaluating the merits and risks of participation in the Plan. Service
Provider understands that his or her participation in the Plan shall not begin
until this Acknowledgment has been signed by Service Provider and returned to
Employer.

        Dated:_____________________________________________

        Signed:____________________________________________
                      Service Provider

        Dated:_____________________________________________
                      AMYLIN PHARMACEUTICALS, INC.

        Signed:____________________________________________
                      [Officer]

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