Document:

Exhibit

	
															
	AMENDMENT OF SOLICITATION/MODIFICATION OF CONTRACT
	1.   CONTRACT ID CODE
	PAGE   OF   PAGES

	1
	2
	 

	2.  AMENDMENT/MODIFICATION NO.
	3.  EFFECTIVE DATE
	4.  REQUISITION/PURCHASE REQ. NO.
	 5.  PROJECT NO. (if applicable)

	0040
	See Block 16C
	N/A.
	 

	6.  ISSUED BY
	CODE
	ASPR-BARDA
	7.  ADMINISTERED BY (If other than Item 6)

	CODE
	ASPR-BARDA02

	ASPR-BARDA
200 Independence Ave., S.W.
Room 640-G
Washington DC 20201

	ASPR-BARDA
330 Independence Ave, SW, Rm G640
Washington DC 20201

	8.  NAME AND ADDRESS OF CONTRACTOR (No., street, county, State and ZIP Code)
	x
	9A.  AMENDMENT OF SOLICITATION NO.

	

CHIMERIX, INC. 1377270
CHIMERIX, INC.   2505   MERIDIAN P
2505 MERIDIAN PKWY STE 340
DURHAM NC 277135246
	 
	 

	 9B.  DATED (SEE ITEM 11)

	 
	 

	x
	 10A.  MODIFICATION OF CONTRACT/ORDER NO.
 HHSO100201100013C

	 

	 10B.  DATED (SEE ITEM 13)
02/16/2011

	CODE
1377270
	FACILITY CODE
	 

	11.  THIS ITEM ONLY APPLIES TO AMENDMENTS OF SOLICITATIONS

	o   The above numbered solicitation is amended as set forth in Item 14. The hour and date specified for receipt of Offers   o  is extended.    o is not extended
Offers must acknowledge receipt of this amendment prior to the hour and date specified in the solicitation or as amended, by one of the following methods: (a) By completing Items 8 and 15, and returning ___________ copies of the amendment; (b) By acknowledging receipt of this amendment on each copy of the offer submitted; or (c) By separate letter or telegram which includes a reference to the solicitation and amendment numbers.  FAILURE OF YOUR ACKNOWLEDGEMENT TO BE RECEIVED AT 
THE PLACE DESIGNATED FOR THE RECEIPT OF OFFERS PRIOR TO THE HOUR AND DATE SPECIFIED MAY RESULT IN REJECTION OF YOUR OFFER. If by    
virtue of this amendment you desire to change an offer already submitted, such change may be made by telegram or letter, provided each telegram or letter makes    
reference to the solicitation and this amendment, and is received prior to the opening hour and date specified.

	12.  ACCOUNTING AND APPROPRIATION DATA (if required)
 N/A.                                                                                                                                                            

	13.  THIS ITEM ONLY APPLIES TO MODIFICATION OF CONTRACTS/ORDERS. IT MODIFIES THE CONTRACT/ORDER NO. AS DESCRIBED IN ITEM 14.

	CHECK ONE
	A.   THIS CHANGE ORDER IS ISSUED PURSUANT TO:  (Specify authority)  THE CHANGES SET FORTH IN ITEM 14 ARE MADE IN THE CONTRACT ORDER NO. IN ITEM 10A.

	 

	 
	B.   THE ABOVE NUMBERED CONTRACT/ORDER IS MODIFIED TO REFLECT THE ADMINISTRATIVE CHANGES (such as changes in paying office, appropriation date, etc.) SET FORTH IN ITEM 14, PURSUANT TO THE AUTHORITY OF FAR 43.103(b).

	 
	C.   THIS SUPPLEMENTAL AGREEMENT IS ENTERED INTO PURSUANT TO AUTHORITY OF:

	X
	D.   OTHER (Specify type of modification and authority)
Bilateral:  Mutual Agreement of the Parties.

	E.  IMPORTANT:   Contractor   o  is not.   x  is required to sign this document and return            0    copies to the issuing office.

	14.  DESCRIPTION OF AMENDMENT/MODIFICATION (Organized by UCF section headings, including solicitation/contract subject matter where feasible.)

	Tax ID Number:   33-0903395
DUNS Number:   121785997

A. The purpose of this modification is to incorporate the following changes into the
contract:

1. The period of performance for Option 2/CLIN 0003 of Contract Number HHSO100201100013C
ONLY is hereby changed from 1 September 2014 through 30 June 2017 to 1 September 2014
Through 31 July 2017, at no additional cost to the Government.  The total amount and scope
Of Option 2/CLIN 0003 of Contract Number HHSO100201100013C remains unchanged.

 2. The period of performance for CLIN 0004 of Contract Number HHSO100201100013C ONLY is

	

Continued . . .
Except as provided herein, all terms and conditions of the document referenced in Item 9A or 10A, as heretofore changed, remains unchanged and in full force and effect.

	15A.  NAME AND TITLE OF SIGNER (Type or print)
	 16A.  NAME AND TITLE OF CONTRACTING OFFICER (Type or print)

	Timothy W. Trost, SVP & CFO
	ETHAN J. MUELLER

	15B.  CONTRACTOR/OFFEROR
	15C.  DATE SIGNED
	16B.  UNITED STATES OF AMERICA
	16C.  DATE SIGNED

	   /s/ Timothy W. Trost
       (Signature of person authorized to sign)
	6/14/17
	   /s/ Ethan J. Mueller   
             (Signature of Contracting Officer)
	6/16/17

NSN 7540-01-152-8070    STANDARD FORM 30 (REV. 10-83)
Previous edition unusable    Prescribed by GSA
FAR (48 CFR) 53.243

	
									
	CONTINUATION SHEET
	REFERENCE NO. OF DOCUMENT BEING CONTINUED
HHSO100201100013C/0040
	PAGE   OF

	2
	2

	NAME OF OFFEROR OR CONTACTOR
CHIMERIX, INC. 1377270

	ITEM NO.
(A)
	SUPPLIES/SERVICES
(B)
	QUANTITY
(C)
	UNIT
(D)
	UNIT PRICE
(E)
	AMOUNT
(F)

	 
	hereby changed from 11 September 2015 through 30 June 2017 to 11 September 2015
through 31 July 2017, at no additional cost to the Government.  The total amount and 
scope of CLIN 0004 of Contract Number HHSO100201100013C remains unchanged.

3. The total amount, scope and period of performance of all other CLINs that are 
currently being performed under the contract remain unchanged. This modification 
does not exercise any unexercised Option CLINs under the contract and does not 
authorize any performance of efforts under any unexercised Option CLINs under the 
contract. In addition, the total amount, scope and period of performance of all 
unexercised Option CLINs under the contract remain unchanged. This modification 
also confirms that all activities under the base period of performance CLIN 0001 
were completed as of 31 May 2013 and confirms that all activities under the Option 
l/CLIN 0002 period of performance were completed as of 30 April 2015.

B. This is a no cost bilateral modification. All other terms and conditions of
Contract Number HHSO100201100013C remain unchanged.

Period of Performance: 02/16/2011 to 07/31/2017

NSN 7540-01-152-8067                                          OPTIONAL FORM 336 (4-86)
     Sponsored by GSA
FAR (48 CFR) 53.110Exhibit

EIGHTH AMENDMENT TO OFFICE LEASE
THIS EIGHTH AMENDMENT TO OFFICE LEASE (this "Eighth Amendment") is made as of this 13th day of July, 2017 (the "Effective Date"), by and between IVC MERIDIAN TT O, LLC, a Delaware limited liability company ("Landlord"), and CHIMERIX, INC., a Delaware corporation ("Tenant").
W I T N E S S E T H :
WHEREAS, pursuant to that certain Office Lease dated September 1, 2007 (the "Original Lease"), ACP 2505 Meridian LLC ("Original Landlord") leased to Tenant, and Tenant leased from Original Landlord, approximately 6,849 rentable square feet of office space (the "Original Premises") known as Suite 340 on the third (3rd) floor of the building located at 2505 Meridian Parkway, Durham, North Carolina 27713 (the "Building"); 
WHEREAS, pursuant to that certain First Amendment to Office Lease dated December 19, 2008 (the "First Amendment"), Original Landlord and Tenant amended the Original Lease to provide for the demise to Tenant of the Additional Premises (as more particularly described in the First Amendment), upon the terms and conditions set forth in the First Amendment; 
WHEREAS, pursuant to that certain Second Amendment to Office Lease dated January 21, 2011 (the "Second Amendment"), Original Landlord and Tenant amended the Original Lease, as amended, to provide for the extension of the Term until February 29, 2012;
WHEREAS, AREP Meridian I LLC (“AREP MI”) succeeded to the interest of Original Landlord under the Original Lease, as amended; 
WHEREAS, pursuant to that certain Third Amendment to Office Lease dated March 1, 2012 (the "Third Amendment"), AREP MI and Tenant amended the Original Lease, as amended, to provide for the extension of the Term until February 28, 2013; 
WHEREAS, pursuant to that certain Fourth Amendment to Office Lease dated February 13, 2013 (the "Fourth Amendment"), AREP MI and Tenant amended the Original Lease, as amended, to provide for the extension of the Term until February 28, 2018; 
WHEREAS, pursuant to that certain Fifth Amendment to Office Lease dated July 2, 2014 (the "Fifth Amendment"), AREP MI and Tenant amended the Original Lease, as amended, to provide for the demise to Tenant of the Second Additional Premises (as more particularly described in the Fifth Amendment), upon the terms and conditions set forth in the Fifth Amendment;
WHEREAS, Landlord has succeeded to the interest of AREP MI under the Original Lease, as amended; 
WHEREAS, pursuant to that certain Sixth Amendment to Office Lease dated April 28, 2015 (the "Sixth Amendment"), Landlord and Tenant amended the Original Lease, as amended, to provide for (i)  the extension of the Term until the Modified Expiration Date; (ii) the demise to Tenant of the Third Additional Premises (as more particularly described in the Sixth Amendment); (iii) the demise to Tenant of the Fourth Additional Premises (as more particularly described in the Sixth Amendment); and (iv) the demise to Tenant of the Fifth Additional Premises (as more particularly described in the Sixth Amendment), all upon the terms and conditions set forth in the Sixth Amendment;
WHEREAS, pursuant to that certain Seventh Amendment to Office Lease dated March 10, 2017 (the "Seventh Amendment"), Landlord and Tenant amended the Original Lease, as amended, upon the terms and conditions set forth in the Seventh Amendment; and
WHEREAS, Landlord and Tenant desire to amend the Original Lease, as amended, to provide for (i) the termination of the Lease (hereinafter defined) with respect to the Third Additional Premises only; and (ii) the vacation by Tenant of the Third Additional Premises only, all upon the terms and conditions set forth in this Eighth Amendment.
NOW, THEREFORE, in consideration of the foregoing and for other good and valuable consideration and of the mutual agreements hereinafter set forth, it is hereby mutually agreed as follows:
1.    Incorporation of Recitals.  The foregoing recitals are hereby incorporated in this Eighth Amendment and are made a part hereof by this reference.
2.    Definitions.  All capitalized terms used in this Eighth Amendment shall have the meanings ascribed thereto in the Original Lease, as amended, unless otherwise defined herein.  As used herein and in the Original Lease, as amended, the term "Lease" shall mean the Original Lease, as amended by the First Amendment, the Second Amendment, the Third Amendment, the Fourth Amendment, the Fifth Amendment, the Sixth Amendment, the Seventh Amendment and this Eighth Amendment.  As used in the Lease: (i) between the Effective Date of this Eighth Amendment and the TAP Termination Date (hereinafter defined), the term "Premises" shall mean and refer to the Original Premises together with the Additional Premises, the Second Additional Premises, the Third Additional Premises, the Fourth Additional Premises and the Fifth Additional Premises (consisting of approximately 29,053 rentable square feet of space in the aggregate); and (ii) from and after the date immediately following the TAP Termination Date, the term "Premises" shall mean the Original Premises together with the Additional Premises, the Second Additional Premises, the Fourth Additional Premises and the Fifth Additional Premises (consisting of approximately 24,862 rentable square feet of space in the aggregate).   
3.    Termination of Lease with Respect to the Third Additional Premises.  Subject to the terms and conditions set forth herein, the Term with respect to the Third Additional Premises only shall terminate as of 11:59 p.m. on July 14, 2017 (the "TAP Termination Date").  Landlord, and, provided Tenant, and/or any party claiming by, through or under Tenant, timely vacates and surrenders possession of the Third Additional Premises to Landlord as provided in Paragraph 4, below, Tenant shall each be released from any and all obligations under the Lease with respect to the Third Additional Premises only which accrue after the TAP Termination Date.

4.    Surrender of the Third Additional Premises by Tenant.  Tenant, and/or any party claiming by, through, or under Tenant, shall vacate and surrender to Landlord possession of the Third Additional Premises on or before 11:59 p.m. on the TAP Termination Date vacant, broom clean, with all personal property removed and otherwise in accordance with the terms and provisions of the Lease.  Should Tenant, and/or any party claiming by, through or under Tenant, fail to vacate the Third Additional Premises on or before the TAP Termination Date and/or fail to surrender the Third Additional Premises to Landlord in the condition required pursuant to the terms of the Lease on or before the TAP Termination Date:  (i) Tenant shall be deemed a holdover tenant in the Third Additional Premises, (ii) Tenant shall be subject to the provisions of Article 24 of the Original Lease (captioned, "Holding Over") with respect to the Third Additional Premises; and (iii) Landlord may re-enter and take possession of the Third Additional Premises without having to bring an action for possession against Tenant and Landlord may otherwise exercise any "self-help" remedy of its choice, including without limitation by way of locking Tenant, and/or any party claiming by, through or under Tenant, out of the Third Additional Premises.  Tenant shall indemnify and hold harmless Landlord from and against any and all claims, liabilities, costs, expenses, losses and damages (including without limitation attorneys' fees and consequential damages) incurred by Landlord as a result of Tenant's, and/or any party claiming by, through or under Tenant, failure to vacate (or surrender to Landlord) the Third Additional Premises by the TAP Termination Date in accordance with the terms of the Lease.
5.    Termination Fee.  Tenant shall pay Landlord a termination fee (the “Termination Fee”) in the amount of Fifty-Five Thousand Dollars ($55,000.00) in connection with the termination of the Lease with respect to the Third Additional Premises.  Tenant shall pay the Termination Fee to Landlord simultaneously with Tenant's execution and delivery to Landlord of this Eighth Amendment.  
6.    Tenant’s New Share.  From and after July 14, 2017, Tenant’s New Share shall be decreased from 68.74% to 58.82%.
7.    Counterpart Copies.  This Eighth Amendment may be executed in two (2) or more counterpart copies, all of which counterparts shall have the same force and effect as if all parties hereto had executed a single copy of this Eighth Amendment.
8.    Miscellaneous.  This Eighth Amendment (a) shall be binding upon and inure to the benefit of the parties hereto and their respective representatives, transferees, successors and assigns and (b) shall be governed by and construed in accordance with the laws of the State of North Carolina.
9.    Ratification.  Except as expressly amended by this Eighth Amendment, all other terms, conditions and provisions of the Original Lease, as amended, are hereby ratified and confirmed and shall continue in full force and effect.
[Signature Page Follows]

IN WITNESS WHEREOF, the parties hereto have executed this Eighth Amendment to Office Lease under seal as of the day and year first hereinabove written.
LANDLORD:
IVC MERIDIAN TT O, LLC, 
a Delaware limited liability company

By: __/s/ J. Michael O’Brien_____________ 
      Name: J. Michael O’Brien 
      Title: Vice President
TENANT:
CHIMERIX, INC., 
a Delaware corporation

By:  __/s/ M. Michelle Berrey___________
       Name: M. Michelle Berrey, MD, MPH
       Title: President and CEO 

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