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                                                                   EXHIBIT 10.41

                        FIRST AMENDMENT TO NOTE AGREEMENT
                     AND PREFERRED STOCK PURCHASE AGREEMENT

         This First Amendment to Note Agreement and Preferred Stock Purchase
Agreement (this "Amendment") is entered into as of November 3, 1999, by and
between Scios Inc., a Delaware corporation formerly known as "Scios Nova Inc."
(the "Company"), and Genentech, Inc., a Delaware corporation (the "Lender").

                                    RECITALS

         A. The Company and the Lender entered into a Note Agreement dated as of
December 30, 1994 (the "Note Agreement"), pursuant to which Lender has made an
interest-bearing loan of $30,000,000 to the Company (the "Loan"). The Loan is
due and payable in full on December 31, 2002.

         B. The Note Agreement authorizes and permits the Company to repay the
principal balance of and all accrued and unpaid interest under the Note through
cash payments, the Company's issuance to the Lender of shares of the Company's
common stock ("Note Shares"), or a combination of both.

         C. The Company and the Lender also entered into a Preferred Stock
Purchase Agreement dated as of December 30, 1994 (the "Stock Agreement"),
pursuant to which (among other things) the Company agreed to cause the Note
Shares to be registered under the circumstances described therein.

         D. The parties wish to amend the Note Agreement and the Stock Agreement
as set forth herein.

                                    AGREEMENT

         NOW THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, the parties agree as follows:

1. AMENDMENT OF SECTION 3 OF THE NOTE AGREEMENT

         The first paragraph of Section 3 of the Note Agreement is hereby
amended and restated to read in its entirety as follows:

         "3. Payment. The principal amount of and interest accrued on this Note
shall be payable, at the option of the Company, by either of the following means
or a combination thereof:

             (a)  in cash denominated in the currency of the United States of
                  America (a "Cash Payment"); or

             (b)  by the issuance from time to time of Series B Preferred
                  Stock of the Company with the rights and preferences as
                  described in Exhibit 1 hereto and, for

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             c)  purposes of determining the amount paid against the Note,
                 valuing each share of Series B Preferred Stock as equal to
                 the product of multiplying (X) the average closing price of
                 the Company's Common Stock (as reported by NASDAQ, or as
                 traded on a securities exchange, as applicable) over the
                 thirty-day period ending on the day preceding the payment by
                 (Y) 100, (a "Stock Payment");

                 PROVIDED, HOWEVER, that: (i) in no event shall the Company
                 repay more than Twenty Five Million Dollars ($25,000,000) of
                 the Note by Stock Payments; (ii) in no event shall Company
                 have the right to apply more than eight (8) separate Stock
                 Payments toward repayment of the Note; (iii) not later than
                 the earlier of the date of the first Stock Payment or
                 January 30, 2000, Company will make a $2,000,000 Cash
                 Payment under the Note; and (iv) contemporaneously with each
                 Stock Payment, the Company will make a Cash Payment
                 determined under the following formula:

                             Amount of Cash Payment = C  x  (A-B)
                                                      -
                                                      B

                 Where:

                 A equals the aggregate amount (principal and interest)
                 outstanding under the Note, calculated immediately prior to
                 such Stock Payment;

                 B equals the amount of the remaining permitted Stock
                 Payments under the Note, calculated immediately prior to
                 such Stock Payment; and

                 C equals the amount of the current Stock Payment.

Payments of principal and accrued interest shall be made at the address of the
Lender, set forth in the Collaboration Agreement, or such other place as the
Lender shall have notified the Company in writing at least five days before such
payment is due. All payments in respect of this Note shall be applied first to
accrued and unpaid interest hereon, and thereafter to the unpaid principal
amount hereof. This Note may be prepaid by the Company without penalty, in whole
or in part by any of the means described above at any time."

2.   UNDERSTANDINGS WITH RESPECT TO REGISTRATION AND RESALE OF NOTE SHARES

         The parties agree that the Company's obligation to register any Note
Shares is governed by the Stock Agreement. The Lender hereby agrees that
notwithstanding any contrary provision of the Stock Agreement or the Note
Agreement: (A) none of the Note Shares shall be sold, assigned or transferred
prior to December 30, 2002 except with the prior written approval of the
Company, which the Company may grant or withhold in its sole discretion; and (B)
and the Company shall not be required to file any registration statement prior
to December 30, 2002 pursuant to the Stock Agreement to register any of the Note
Shares unless, following a written request by the Lender, the Company determines
in its sole discretion to effect such registration

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because it believes that market conditions are then suitable for a sale of all
or a portion of the Note Shares. The Company agrees that: (A) if after December
30, 2002 and before January 20, 2003 Lender requests the filing of a
registration statement covering the Note Shares pursuant to the Stock Agreement,
Company will use reasonable efforts to cause such registration statement to
become effective not later than February 15, 2003; and (B) in connection with
any registration of Note Shares pursuant to the Stock Agreement, the Company
will use reasonable efforts (to the extent permitted by applicable securities
laws and other legal requirements) to support the sale of the Note Shares by the
Lender in the public market through interactions with potential investors and
analysts designed to educate them about the Company.

3.       AMENDMENT OF SECTION 5 OF THE STOCK AGREEMENT

Section 5 of the Stock Agreement is hereby amended by adding the following new
subsection (f):

                  "(f) The Purchaser may sell, assign or transfer all or a
         portion of the Securities and the Note Shares to a third party or
         related party investor (each, an "Investor"); provided, that such
         transfers shall not exceed four (4) in total and shall in the aggregate
         across all transfers be to no more than six (6) separate Investors. In
         the event of a transfer to one or more Investors under this Section
         5(f), the rights granted to the Purchaser under Section 8 of this
         Agreement to cause the Company to register the Securities and the Note
         Shares may be transferred or assigned by Purchaser to the Investor(s);
         provided, that the Company is given written notice of such transfer,
         stating the name and address of the Investor(s) and identifying the
         Securities and/or Note Shares with respect to which such registration
         rights are being transferred or assigned, and provided further, that
         the Investor(s) assumes the obligations of such Purchaser under Section
         8 of this Agreement (in which case, the Investor(s) becomes a "Holder'"
         as defined under Section 8(a) of this Agreement, for purposes of this
         Agreement)." Notwithstanding the foregoing, this subsection in no way
         limits the Purchaser's right to sell any Securities or Note Shares to
         another party pursuant to the provisions of Rule 144 or an effective
         registration statement under the Act.

4.    MISCELLANEOUS

         The parties agree and confirm that the Note Agreement and Stock
Agreement shall remain in full force and effect in accordance with their
original terms except as amended hereby. This Amendment shall be construed and
enforced in accordance with the laws of the State of California without regard
to principles of conflicts of laws. This Amendment may be executed in
counterparts.

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         IN WITNESS WHEREOF, this First Amendment to Note Agreement and
Preferred Stock Purchase Agreement has been executed and delivered as of the
date first above written by duly authorized representatives of the Company and
the Lender.

         SCIOS INC.

                  /s/ Richard B. Brewer

         By:
            --------------------------------------------
                  Richard B. Brewer
                  President and Chief Executive Officer

         GENENTECH, INC.

                  /s/Brad Goodwin

         By:
            --------------------------------------------

         Name:    Brad Goodwin

         Its:     VP - Finance

Doc. # 68727v2

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                                                                   EXHIBIT 10.42

                                 PROMISSORY NOTE

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED,
HYPOTHECATED OR OTHERWISE TRANSFERRED IN THE ABSENCE OF AN EFFECTIVE
REGISTRATION STATEMENT UNDER SAID ACT COVERING THE TRANSFER OF THE SECURITIES OR
AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT
REQUIRED.

$7,500,000                                             Sunnyvale, California
                                                              December 27, 1999
         FOR VALUE RECEIVED, the undersigned, Scios Inc., a Delaware corporation
(the "Borrower"), hereby promises to pay to the order of Chiron Corporation, a
Delaware corporation ("Chiron"), the principal sum of Seven Million Five Hundred
Thousand Dollars ($7,500,000), including interest as hereinafter provided. The
entire balance of outstanding principal and accrued and unpaid interest shall be
paid in full December 31, 2006, unless the loan has been earlier forgiven as
provided below.

         Interest shall accrue on the unpaid balance of the principal amount at
the rate of 8.5% compounded annually on the anniversary date of this Note and
calculated on the basis of a 360-day year and the number of days actually
elapsed with respect to the outstanding balance from time to time. Interest may
be paid from time to time as Scios elects or deferred until the principal is
paid in full. Accrued interest, together with all outstanding principal shall be
due and payable as set forth in the preceding paragraph.

         Principal, interest and all other amounts due under this Note shall be
payable by wire transfer in accordance with the wire transfer instructions
provided by Chiron, or by such other means as the holder of this Note may from
time to time designate in writing to the Borrower.

         The Borrower shall have the right, at any time, to prepay all or any
part of the outstanding principal amount without premium or penalty; provided,
however, that all payments hereunder shall first be applied to accrued and
unpaid interest and thereafter to principal.

         The Borrower hereby waives presentment, demand, notice, protest and
other demands and notices in connection with the delivery, acceptance or
enforcement of this Note.

         No delay or omission on the part of the holder of this Note in
exercising any right hereunder shall operate as a waiver of such right or of any
other right under this Note, and a waiver, delay or omission on any one occasion
shall not be construed as a bar to or waiver of any such right on any future
occasion.

         The Borrower hereby agrees to pay on demand all reasonable costs and
expenses, including, without limitation, attorneys' fees and legal expenses,
incurred or paid by the holder of this Note in enforcing this Note on default.

                                                                              1.
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         Upon receipt by the Borrower of evidence reasonably satisfactory to it
of the loss, theft, destruction or mutilation of this Note, and indemnity
satisfactory to the Borrower (in the case of loss, theft or destruction) or
cancellation of the Note (in the case of mutilation), the Borrower will make and
deliver to Chiron a new Note of like tenor and principal amount and dated as of
the date to which interest has been paid on the unpaid principal balance
hereunder.

         The following events are the Events of Default under this Note:

         (a)  Scios shall (i) voluntarily commence any proceeding or file any
              petition seeking relief under Title 11 of the United States Code
              or any other federal, state or foreign bankruptcy, insolvency,
              liquidation or similar law, (ii) consent to the institution of,
              or fail to contravene in a timely and appropriate manner, any
              such proceeding or the filing of any such petition, (ii) apply
              for or consent to the appointment of a receiver, trustee,
              custodian, or similar official for Scios or for a substantial
              part of its property or assets, (iv) file an answer admitting the
              material allegations of a petition filed against it in any such
              proceeding, (v) make a general assignment for the benefit of
              creditors, (vi) become unable, admit in writing its inability or
              fail generally, to pay its debts as they become due, or (vii)
              take corporate action for the purpose of effecting any of the
              foregoing;

         (b)  an involuntary proceeding shall be commenced or an involuntary
              petition shall be filed in a court of competent jurisdiction
              seeking (i) relief in respect of Scios' or of a substantial part
              of its property or assets under Title 11 of the United States
              Code or any other federal, state or foreign bankruptcy,
              insolvency, receivership or similar law, (ii) the appointment of
              a receiver, trustee, custodian, or similar official for Scios or
              for a substantial part of its property, or (iii) the winding-up
              or liquidation of Scios; and such proceeding or petition shall
              continue undismissed for sixty (60) days or an order or decree
              approving or ordering any of the foregoing shall continue
              unstayed and in effect for thirty (30) days; and

         (c)  this Note shall for any reason cease to be, or be asserted by
              Scios not to be, a legal, valid and binding obligation
              enforceable in accordance with its terms.

         Upon the happening of an Event of Default described in paragraph (a) or
(b) above, this Note shall automatically become due and payable, both as to
principal and interest, without presentment, demand, protest or other notice of
any kind, all of which are hereby expressly waived by Scios. Upon the happening
of an Event of Default described in paragraph (c) above, and at any time
thereafter during the continuance of such event, the holder of this Note may, by
written or telegraphic notice to Scios, declare the Note to be forthwith due and
payable, whereupon the principal of this Note, together with accrued interest
thereon and other liabilities of Scios accrued hereunder, shall become due and
payable both as to principal and interest, without presentment, demand, protest
or any other notice of any kind, all of which are hereby expressly waived by
Scios.

         The obligation of Scios represented by this Note shall be subordinate
to all other debt or obligations of Scios regardless of the date that such other
debt or obligation may be created. Chiron agrees to execute any document
reasonably requested by Scios or another creditor of Scios to evidence the
subordination of this Note to other obligations of Scios.

                                                                              2.
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         This Note shall be deemed to be under seal, and all rights and
obligations hereunder shall be governed by the laws of the State of California.

         This Note, including all outstanding principal and accrued and unpaid
interest, shall automatically be forgiven and Scios shall have no further
obligation of any kind to Chiron under this Note upon the granting of a New Drug
Approval by the United States Food and Drug Administration ) prior to December
31, 2006 authorizing the marketing in the United States of any FGF Product (as
defined in the FGF License and Technology Transfer Agreement).

AGREED:
SCIOS INC.                                CHIRON CORPORATION

         /s/ Richard B. Brewer                     /s/ James R. Sulat
By:                                       By:
   -----------------------------             -----------------------------------
         Richard B. Brewer                Name:    James R. Sulat
         President and CEO                Title:   Chief Financial Officer

                                                                              3.

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