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  Exhibit 10.46    
    

LEASE

Between 

Iowa State University Research Park Corporation  

(Landlord) 

and

NewLink Genetics, Inc.

(Tenant)

Space:

Suite 3900

Wayne R. Moore Technology Transfer Center,

Building #3 

Date:
 September 1, 2000  

Address of Tenant to which

Notices shall be sent 

 
    NewLink Genetics, Inc.
  Suite 3900
  2901 South Loop Drive
  Ames, IA 50010    
    

1

 

 
 

  TABLE OF CONTENTS    
    

 

 

					
	PAGE

 
	 	PARAGRAPH 	 	HEADING 
	 3
	 	 	 	Summary
	 4
	 	1	 	Premises
	 4
	 	2	 	Term
	 4
	 	3	 	Base Rent
	 4
	 	4	 	Operating Costs
	 5
	 	5	 	Use
	 6
	 	6	 	Landlord's Maintenance
	 7
	 	7	 	Tenant's Maintenance
	 7
	 	8	 	Parking
	 7
	 	9	 	Alterations
	 8
	 	10	 	Signs
	 8
	 	11	 	Inspection
	 8
	 	12	 	Assignment and Subletting
	 9
	 	13	 	Fire and Casualty
	 9
	 	14	 	Liability
	 10
	 	15	 	Condemnation
	 10
	 	16	 	Holding Over
	 10
	 	17	 	Quiet Enjoyment
	 11
	 	18	 	Default
	 11
	 	19	 	Landlord's Remedies
	 12
	 	20	 	Mortgage Subordination
	 12
	 	21	 	New Owner
	 12
	 	22	 	Mechanic's Liens
	 12
	 	23	 	Notices
	 12
	 	24	 	Business Interruption
	 12
	 	25	 	Delivery of Goods
	 12
	 	26	 	Nondiscrimination
	 13
	 	27	 	Landlord Refusal to Consent
	 13
	 	28	 	Entire Agreement
	 13
	 	29	 	Captions, Deletions, Definitions
	 16
	 	 	 	Attachment 1
	 17
	 	 	 	Attachment 2
	 
	 	 	 	Attachment 3
	 
	 	 	 	Amortization Schedule

 

 2

 

 
 

  SUMMARY PAGE    
    

        This page summarizes operational information from the body of the Lease for the convenience of the Landlord. In the event of a conflict
between information contained herein and that contained in the body of the Lease, the terms of the body of the Lease shall prevail: 

 

 

					
	 1.
	 	Tenant	 	 NewLink Genetics, Inc.
	 2.
	 	 Space:
	 	 Suite 3900 (± 3,990 g.s.f.), Wayne R. Moore Technology Transfer Center, Building #3

	 3.
	 	 Term:
	 	  September 1, 2000 through August 31,
2005

	 4.
	 	  Base Rent and Operating Costs:

 

  

 

 

																				
	 
	 	Square Feet 	 	 
	 	 
	 	 
	 	 
	 
	 
	 	Monthly

Base 	 	Monthly

Operating 	 	Yearly

Base 	 	Yearly

Operating 	 
	Term

 
	 	Base 	 	Operating 	 
	9/1/2000

8/31/2001	 	$	11.50	 	$	1.00	*	$	3,823.75	 	$	332.50	 	$	45,885.00	 	$	3,990.00	 
	
9/1/2001

8/31/2002	
 	
$	

12.50	
 	
$	

2.00	
*	
$	

4,156.25	
 	
$	

665.00	
 	
$	

49,875.00	
 	
$	

7,980.00	
 
	
9/1/2002

8/31/2003	
 	
$	

13.00	
 	
 	
Actual	
 	
$	

4,322.50	
 	
 	
Actual	
 	
$	

51,870.00	
 	
 	
Actual	
 
	
9/1/2003

8/31/2004	
 	
$	

13.50	
 	
 	
Actual	
 	
$	

4,488.75	
 	
 	
Actual	
 	
$	

53,865.00	
 	
 	
Actual	
 
	
9/1/2004

8/31/2005	
 	
$	

14.50	
 	
 	
Actual	
 	
$	

4,821.25	
 	
 	
Actual	
 	
$	

57,855.00	
 	
 	
Actual	
 

 

 

	*
	Estimated
operating costs. 

 

         Landlord
agrees to pay $174,696 of the estimated tenant finish costs for Suite 3900. Tenant will pay tenant finish costs in excess of this amount, currently estimated at $93,780.
Landlord agrees to finance Tenant's improvement costs up to $93,780 to be charged as additional rent. Landlord will amortize the improvements over a 10-year term for an additional
$1,132.87 per month (see Amortization Schedule) with a recapture provision for the balance of the loan due at the end of the five-year lease term. (The above example assumes a 7.90%
interest rate. Actual amount will be based on rate received from lender.) Other amenities provided by Landlord in the wet-lab area include the use of a conference room, a breakroom, other
shared lab facilities, vacuum system, and shared equipment. 

        As
security for these improvements, Landlord will require a letter of credit in the amount of $50,000 for the term of the lease until Tenant has secured $1 million in equity
investment from private placement offering. 

        Landlord
estimates that Suite 3900 will be completed by August 31, 2000. Should the suite not be completed by this date, this five-year term will begin upon its
completion of the building. 

        Gas
and water usage, as well as utility costs for the HVAC system, will be prorated and invoiced monthly. Electricity is metered separately and will be invoiced directly from the
provider. 

3

 
 
 

  LEASE    
    

        This Lease is entered into this 10th day of May, 2000 by and between Iowa State University Research Park Corporation, an Iowa 504A
corporation ("Landlord"), and NewLink Genetics, Inc., a corporation organized pursuant Delaware law, ("Tenant"). 

        1.    PREMISES:    Landlord hereby leases to Tenant certain premises
at the Iowa State University Research Park ("Park") more particularly described on Attachment 1 attached hereto and incorporated herein (hereinafter referred to as the "Demised Premises"). Lease of
the Demised Premises is subject to the terms and conditions of this Lease. The Demised Premises contain ±3,990 gross square feet. Whenever reference is made herein to
Tenant's pro rata share based upon square feet of the Demised Premises, this number shall define square feet of the Demised Premises. 

        2.    TERM:    The term of the Lease shall start on
September 1, 2000 and terminate on August 31, 2005. If there is any option to renew this lease, such option shall be included on Attachment 2. 

        A.    Landlord
has made no representations as to the repair of the Demised Premises, or promises to alter, remodel or improve the Demised Premises, except as set forth in
Attachment 2 herein. Tenant's taking possession of the Demised Premises shall conclusively show that the Demised Premises are in good and satisfactory condition. 

        B.    If
the Demised Premises are not ready for occupancy on the date that this Lease is due to commence (because construction has not been completed, or because the Demised
Premises are not vacant, or for any other reason) Landlord shall not be in default hereunder. Tenant shall accept possession of the Demised Premises when Landlord is able to deliver same. The term of
this Lease shall then begin on the date of delivery, but the end of the Lease term shall remain the same. Landlord hereby waives payment of rent covering any period prior to tendering of possession of
the Demised Premises to Tenant. On the date the Lease term begins, Tenant shall execute and deliver to Landlord a letter of acceptance of delivery of the Demised Premises. 

        3.    BASE RENT:    Tenant shall pay annual rent of $45,885.00 in
equal monthly installments of $3,823.75 (payable monthly in advance) during the first year of the term of this Lease. Rent payments for the balance of this Lease shall be as described at Attachment 2
herein. 

        4.    OPERATING COSTS:    In addition to base rent, Tenant shall pay
the following as operating costs: 

        A.    Tenant
shall pay its pro rata share of disbursements paid by Landlord for the building and appurtenant grounds in which the Demised Premises is located including (without
limitation) Tenant's proportional share of: 1) real property taxes, including all taxes, assessments, special assessments, levies and government charges of any kind and nature whatever
(collectively, "taxes") levied, assessed or payable against building and appurtenant grounds; 2) insurance (including complete pass-through of any additional premiums solely
attributed to activities of Tenant at the Demised Premises); 3) repair, maintenance, janitorial and cleaning, including supplies of areas for which Tenant is not directly responsible;
4) landscape maintenance including regular mowing of grass, trimming, weed removal and general landscaping of appurtenant grounds; 5) snow plowing; 6) common area utilities,
including (without limitation) parking area lighting; 7) water and sewer charges; 8) management and administration expenses; 9) parking lot maintenance and cleaning;
10) other operating costs; and 11) charges payable by Landlord on the property which this Demised Premises is located by the Research Park for maintenance of common areas in the entire
Research Park. 

        B.    Tenant
shall repay Landlord for additional operating costs directly attributable to Tenant within thirty days of statement rendered by Landlord. 

4

 

        C.    If
Landlord desires, Landlord may separately meter any utility to the Demised Premises. Tenant would be directly responsible for payment of such utility charges. 

        D.    Disbursements
paid by Landlord for building, appurtenant grounds, and Research Park grounds (other than those directly attributable to Tenant) shall be proportioned among
all tenants of the building. This shall be calculated as follows: the total reimbursements paid by Landlord for building and appurtenant grounds shall be divided by the number of square feet in
building in which the Demised Premises are located. The resulting amount shall be multiplied by the number of square feet attributed herein to the Demised Premises, and the product shall be Tenant's
pro rata share of Landlord's disbursements. 

        E.    Tenant
shall pay Landlord operating costs due hereunder in monthly installments as follows: 

            i.  Tenant
shall pay such costs according to Landlord's estimate of what they will be, which Landlord shall calculate once a year. Payment shall be made monthly in advance,
together with basic rental payments. 

           ii.  For
the first year of this Lease, Landlord has estimated such disbursements as $1.00 per gross square foot. This sum includes only costs set forth in
Paragraph 4A herein. 

          iii.  After
the close of Landlord's fiscal year, Landlord shall prepare a statement of actual costs for the building in which the Demised Premises are located and
appurtenant grounds. 

          iv.  A
copy of the statement will be furnished to Tenant, and will set forth Tenant's pro rata share of such actual operating costs for which the Tenant is responsible
pursuant to Paragraph 4B herein for which Tenant has not already repaid Landlord. 

           v.  Tenant
shall receive a credit against its share of such costs for operating costs actually paid by it to Landlord. If the sum of Tenant's operating costs payments
hereunder is less than the disbursements actually made by Landlord, the Tenant will be billed for the additional amounts for which he is responsible. Tenant shall pay such bill within thirty
(30) days after it is rendered. If the sum of Tenant's operating costs payments is greater than the actual disbursements made by Landlord, Tenant shall receive a credit against its next month
or months operating costs obligation. 

          vi.  Based
upon the foregoing, the estimated operating costs for which Tenant shall be initially responsible shall be $3.990.00 for the first twelve months after
commencement of term of this Lease; payable $332.50 per month. 

        F.     Tenant
is responsible for paying all charges for its own use of utilities, if such utilities are separately metered. 

        G.    If
Tenant fails to pay rent or operating costs when due, Tenant shall pay Landlord a late charge of five (5%) percent of such overdue payment. Such late charge shall be
in addition to (and not in limitation of) all of Landlord's other rights and remedies hereunder or at law. Such charge shall not be considered liquidated damages. 

        5.    USE:    

        A.    The
Demised Premises shall only be used for: 

        1.     Laboratories,
offices, and other facilities for research, basic, developmental and applied, and consulting, conducted by or for any individual, organization, or concern,
whether public or private. 

        2.     Product
manufacture or assembly shall be restricted to the manufacture or assembly of technology products which are clearly related to the on-site research
and development 

5

 

activities
of the tenant, or to manufacturing processes which require high levels of scientific or technological input. 

        3.     Pilot
plants and test or research facilities in which processes planned for use in production elsewhere can be tested. 

        4.     Incidental
operations required to maintain or support any use permitted in paragraphs 1 through 3 above, on the same tract as the permitted use, such as
maintenance shops, parking garages, keeping of animals, experimental plots, machine shops, and communications or computer facilities. 

        5.     Services
which the Board, in its sole discretion, deems necessary to assist those uses permitted in paragraphs 1 through 3 above including, but not limited to,
accounting, legal, printing, research, day-care, travel planning, and mailing centers. However, such services are to remain ancillary to the primary purpose of the Research Park as
discussed above. 

        6.     Recreational
facilities predominantly for Park tenant use. 

        B.    Outside
storage (including, without limitation, all motor vehicles such as trucks or trailers) is prohibited without Landlord's prior written consent. Tenant shall at its
own cost and expense obtain any and all licenses and permits necessary for its use of the Demised Premises. 

        C.    Tenant
shall comply with all governmental laws, ordinances, regulations, rules, orders and directives (collectively, "regulations"), including (without limitation) all
environmental, energy and zoning regulations, and to any restrictive covenants and rules and regulations of the Research Park. Tenant at its sole expense shall promptly comply with all regulations for
the correction, prevention and abatement of nuisances in, upon, or connected with the Demised Premises. 

        D.    Tenant
shall not permit any objectionable, unpleasant or dangerous odors, smoke, dust, gas, emission, noise or vibrations to emanate from the Demised Premises, nor permit
any activity upon the Demised Premises which would constitute a nuisance or would disturb or endanger any other tenant of the Park. 

        E.    Without
Landlord's prior written consent, Tenant shall not receive, store or otherwise handle any hazardous substance (as defined below) on the Demised Premises. To the
extent Landlord consents to the presence of any hazardous substance on the Demised Premises, in no event shall any such hazardous substance be a substance that is: (i) included on the attached
list of Hazardous Materials Presenting a Physical Hazard in a quantity exceeding the maximum quantity allowed on such list; or (ii) a biological contaminant in excess of biohazard
level 3 or 4 (see Attachment '3'). Tenant shall provide to Landlord annually, on or about July 1, an inventory of the name and quantity of any permitted hazardous substance received,
stored, used, or otherwise handled on the Demised Premises. In addition, Tenant shall receive, store, use, and otherwise handle any such hazardous substance permitted on the Demised Premises in
compliance with all applicable local, state, and federal environmental protection ordinances, regulations, or laws (each an "environmental law"). For purposes of this Lease, a hazardous substance
shall include any substance that (i) is or contains asbestos, urea formaldehyde foam insulation, polychlorinated biphenyls, petroleum or petroleum derived substances or wastes, radon gas, or
related materials; (ii) requires investigation, removal, or remediation under any environmental [GC] law, or is defined, listed,
or identified as a "hazardous waste" or "hazardous substance" thereunder, or (iii) is toxic, explosive, corrosive, flammable, infectious, radioactive, carcinogenic, mutagenic, or otherwise
hazardous and is regulated by any governmental authority or environmental law. 

        6.    LANDLORD'S MAINTENANCE:    Landlord shall at its expense
maintain only the roof, foundation and the structural soundness of the exterior walls (including windows, glass, plate glass, door or entries) of the building in good repair, reasonable wear and tear
excepted. Provided, however, 

6

 

Tenant
shall repair and pay for any damage caused by Tenant or Tenant's employees, agents or invitees, or caused by Tenant's default hereunder. Tenant shall immediately give Landlord written notice of
any defects or need for repairs for which Landlord is responsible, after which Landlord shall have reasonable time to determine whether such repair is needed, and, if so, to repair. Landlord's
liability hereunder shall be limited to the cost of such repairs, maintenance or curing of defect. 

        7.    TENANT'S MAINTENANCE:    

        A.    Tenant
shall, at its own cost and expense, keep and maintain all parts of the Demised Premises (except those for which Landlord is expressly responsible under the terms
of this Lease) clean and in good condition, subject to ordinary wear and tear. Tenant hereby authorizes Landlord to arrange for, at Tenant's expense, Tenant's required cleaning, repair and replacement
of the Demised Premises, including (without limitation): windows, glass and plate glass, doors, any special office entry, interior walls and finished work, floors and floor covering, downpours,
gutters, heating and air conditioning systems, dock boards, truck doors, dock bumpers, paving, plumbing work and fixtures, termite and pest extermination, regular removal of trash and debris, keeping
the whole of the Demised Premises in clean and sanitary condition. Tenant shall not be obliged to repair any damage caused by fire, tornado or other casualty covered by the insurance to be maintained
by Landlord pursuant hereto, except that Tenant shall repair all wind damage to glass except with respect to tornado damage. 

        B.    Tenant
shall not damage any wall or disturb the integrity and support provided by any wall. Tenant shall, at its own cost and expense promptly repair any damage or injury
to any part of the building or grounds caused by Tenant or its employees, agents or invitees. 

        C.    Tenant
shall, at its own cost and expense, enter into a regularly scheduled preventive maintenance/service contract with a maintenance contractor for service of all
plumbing, heating, ventilation and air conditioning systems and equipment within or directly servicing the Demised Premises, unless such system is building wide system, in which case Landlord will
provide such maintenance. The maintenance contractor and the contract must be approved by Landlord in writing in advance. Service contract must include all services suggested by the equipment
manufacturer within the operations/maintenance manual and must become effective within thirty (30) days of the date that the Tenant takes possession of the Demised Premises. A copy of such
executed contract shall be promptly delivered to Landlord. 

        8.    PARKING:    Parking shall be available on a
"first-come, first-served" basis in the parking area adjacent to the Demised Premises, shared by all tenants of that building and Landlord. Landlord
may require that all cars shall be marked with a parking decal provided by Landlord. Tenant shall instruct all of its officers, employees and agents not to park in spaces marked for visitor parking. 

        9.    ALTERATIONS:    

        A.    Tenant
shall not make any alterations, additions or improvement to the Demised Premises (including without limitation roof and wall penetrations) (collectively,
"alterations") without the prior written consent of Landlord. Tenant may, without the consent of Landlord, but at its own cost and expense and in a good and workmanlike manner erect such shelves,
bins, machinery and fixtures as it may deem advisable, so long as such comply with all regulations and do not alter the basic character of, or overload or damage, the building or improvements. 

        B.    All
alterations, additions and improvements erected by Tenant shall be Tenant's property during the term of this Lease. Prior to expiration of this Lease, Tenant shall
(unless Landlord otherwise elects as provided herein) remove all alterations, additions and improvements erected by Tenant and restore the Demised Premises to their original condition by the date of
Lease termination or upon earlier vacating of the Demised Premises. However, Landlord shall have the right to elect, during the thirty (30) days prior to termination or earlier vacating of the
Demised 

7

 

Premises,
that any such alterations, additions and improvements shall become the property of Landlord as of the date of termination or upon earlier vacating of the Demised Premises, and that they
shall not be removed by Tenant. 

        C.    All
removals and restoration to original condition shall be accomplished in a good and workmanlike manner so as not to damage the primary structure or structural quality
of the Demised Premises or building. 

        10.    SIGNS:    Tenant shall not erect any signs upon or within the
Demised Premises without prior written approval of the Landlord. This prohibition shall extend, without limitation, to space within the Demised Premises visible from the outside of the building.
Landlord shall not unreasonably withhold its approval if the proposed sign is consistent with the Park requirements contained within the Covenants and Conditions of the Park. 

        11.    INSPECTION:    Landlord, its agents and representatives, shall
have the tight to enter and inspect the Demised Premises: 

        A.    any
time during business hours for the purpose of ascertaining the condition of the Demised Premises or in order to make such repairs as may be herein required of or
permitted to Landlord; and 

        B.    any
time in the event of an emergency, to be determined in Landlord's sole discretion; and 

        C.    during
the one hundred and twenty (120) days in advance of expiration of this Lease, at any time during business hours to show the Demised Premises. During such
one hundred and twenty (120) days, Landlord shall have the right to erect on the Demised Premises a suitable sign stating that the Demised Premises are available. 

        D.    Tenant
shall meet with Landlord on the Demised Premises for a joint inspection of the Demised Premises thirty (30) days prior to vacating. If Tenant fails to
arrange for such joint inspection, Landlord's inspection at or after Tenant's vacating the Demised Premises shall conclusively determine Tenant's responsibility for repairs and restoration. 

        E.    Landlord
shall at all times have a key to all locks to the Demised Premises. Tenant shall not change or install any locks without Landlord's prior approval for
consistency with Landlord's master key. 

        12.    ASSIGNMENT AND SUBLETTING:    

        A.    Tenant
shall not assign this Lease or sublet the whole or any part of the Demised Premises without prior written consent of Landlord which may be withheld in its sole
discretion. If Landlord consents to such, Tenant shall remain directly, primarily and fully responsible and liable for the payment of the rent herein specified and for compliance with all its other
obligations hereunder. 

        B.    In
the event of default (defined at Paragraph 18 herein), if the Demised Premises or any part thereof have been assigned or sublet, Landlord, in addition to any
other remedies provided herein or by law, may at its option collect directly from such assignee or subtenant all rents becoming due to Tenant under such assignment or sublease and apply such rent
against any sums due to Landlord from Tenant hereunder. Such collections, if any, shall not be a novation or a release of Tenant from any performance of Tenant's obligation hereunder except so much of
rent due as is so collected. 

8

 

 
        13.    FIRE AND CASUALTY:    

        A.    Landlord
shall maintain standard fire and extended coverage insurance covering the building at which the Demised Premises are a part in an amount of not less than eighty
(80%) percent (or for such greater percentage as may be necessary to comply with the provisions of any co-insurance clauses of the policy) of the "replacement cost" thereof as such term is
defined in the Replacement Cost Endorsement to be attached thereto. Such coverage shall insure against the perils of fire, lightning, and extended coverage, such coverages and endorsements to be as
defined, provided and limited in the standard bureau forms prescribed by the insurance regulatory authority for the State of Iowa. Subject to the other provisions in this Paragraph 13, such
insurance shall be for the sole benefit of Landlord and under its sole control. 

        B.    If
the Demised Premises should be damaged or destroyed by fire, wind or other casualty, Tenant shall give Landlord immediate written notice thereof. If the Demised
Premises have been destroyed, or in Landlord's sole judgment damaged beyond usability, Landlord may, in its sole discretion, terminate this Lease and the rent shall be abated during the unexpired
portion of this Lease (effective upon the date of the occurrence of such damage or destruction). No damages shall be payable to Tenant if Landlord so terminates. 

        C.    If
Landlord does not choose to terminate, but rather decides to repair or rebuild the Demised Premises, the rent payable hereunder during the period in which the Demised
Premises are not tenantable shall be reduced to such extent as may be fair and reasonable under all the circumstances during such period of repair or rebuilding. At the completion of such repair or
rebuilding, rent shall resume for the full amount herein set forth for the remainder of the term of the Lease. 

        D.    If
holder of an instrument (defined at Paragraph 20 herein) requires that the insurance proceeds be applied to pay off the indebtedness evidenced by that
instrument, Landlord shall have the right to terminate this Lease by delivering written notice of termination to Tenant within fifteen (15) days after
such requirement is made by any such holder. In such event, all rights and obligations hereunder shall cease and terminate, except for any payments previously due and owing from Tenant to Landlord. 

        E.    To
the extent that either party has insurance payable to it under any policy of insurance (directly or by subjugation), the other party is hereby released from any claim
for loss or damage to property caused by fire or other peril, but only if the releaser's insurance policy (or policies) contains a clause or endorsement to the effect that any such release shall not
adversely affect or impair the policy (including increased premiums) or prejudice the right of the releaser to recover under the policy. 

        This
release shall be effective even if the loss or damage is caused by fault or negligence of the party released, or anyone for whom it is responsible, but this release is effective
only to the extent and limit of the proceeds payable under the releaser's insurance policy. 

        14.    LIABILITY:    

        A.    Covenant not to sue.    Tenant shall not commence an action, interpose a counterclaim, or implead Landlord for
any injury to person or damage to property on or about the Demised Premises resulting from and/or caused in part or whole by: 1) the negligence or misconduct of Tenant, its directors, officers,
agents, servants or employees, or of any other person entering upon the Demised Premises for Tenant's purposes; or 2) Tenant's failure to repair. 

        B.    Indemnification.    Tenant shall at all times indemnify and hold harmless Landlord, its directors, officers,
employees and agents, from any loss, liability, claims, suits, costs, expenses (including, without limitation, attorneys fees) and damages (actual and punitive), arising out of any 

9

 

personal
injury or property damage associated with the Demised Premises. Provided, however, that Tenant shall not indemnify or hold harmless Landlord for personal injury or property damage caused by
gross negligence of Landlord or (but only if Tenant has duly notified Landlord of the need for repair) failure of Landlord to repair any part of the Demised Premises which Landlord is obligated to
repair and maintain hereunder. 

        C.    Insurance.    Tenant shall procure and maintain throughout the term of this Lease a policy or policies of
insurance at its sole cost and expense, insuring Tenant against all claims, demands or actions arising out of or in connection with: (i) the Demised Premises; (ii) the condition of the
Demised Premises; (iii) Tenant's operations, maintenance and use of the Demised Premises; and (iv) all assumed contractual or quasi-contractual liability, including without limitation
Tenant's liability assumed under this Lease. The limits of such policy or policies shall be in aggregate amounts of no less than Two Million ($2,000,000) Dollars. Tenant shall name Landlord and Tenant
as insured. All such policies shall be
procured by Tenant from responsible insurance companies licensed to do business in the State of Iowa and satisfactory to Landlord. Evidence of such insurance shall be provided to Landlord prior to
commencement date of this Lease. 

        15.    CONDEMNATION:    In the event the Demised Premises, or any
portion thereof, shall be taken by Eminent Domain (or by private purchase in lieu thereof): 

        A.    The
proceeds of such taking or purchase shall exclusively belong to Landlord. Tenant shall be entitled to an award made specifically to Tenant for it leasehold estate. 

        B.    This
Lease shall not terminate so long as Tenant can still carry on its business on the Demised Premises but rental shall abate in proportion to space taken. 

        C.    This
Lease shall terminate if it is impossible (by reason of such taking or purchase) for Tenant to still carry on its business on the Demised Premises. 

        16.    HOLDING OVER:    At the termination of this Lease, Tenant shall
yield up immediate possession to Landlord. If Landlord agrees in writing that Tenant may hold over after the expiration or termination of this Lease, the hold over tenancy shall be subject to
termination by Landlord at any time upon not less than thirty (30) days advance written notice, or by Tenant at any time upon not less than thirty (30) days advance written notice. All
other terms and provisions of this Lease shall be applicable during the hold over tenancy, except that Tenant shall pay Landlord as rental through the period of any hold over an amount equal to one
and one-half times the base rent and operating costs in effect on termination date. Such rental shall be computed on a daily basis for each day of the hold over period. No holding over by
Tenant, whether with or without consent of Landlord, shall extend this Lease except as otherwise expressly provided herein. This Paragraph may not be interpreted for any purpose as a consent by
Landlord to any hold over by Tenant. 

        17.    QUIET ENJOYMENT:    Subject to all rights of mortgagees, as set
forth in Paragraph 20 herein Landlord covenants that: 

        A.    It
now has, or will have before Tenant takes possession of the Demised Premises, good title to the Demised Premises. Such title is or shall be free and clear of all liens
and encumbrances, except for liens for current taxes not yet due, such mortgage or mortgages as are permitted by the terms of this Lease, regulations as defined herein, and easements, restrictions and
other conditions of record. 

        B.    Landlord
has full right and authority to enter into this Lease. 

        C.    Tenant,
upon paying rent as required, and performing its other obligations, shall peaceably and quietly have, hold and enjoy the Demised Premises for the term without
hindrance or molestation from Landlord. 

10

 

        18.    DEFAULT:    The following shall be events of default by Tenant
under this Lease: 

        A.    Tenant's
failure to pay any installment of rent or operating costs, required by this Lease when due, and such failure continues for a period of ten (10) days from
the due date. 

        B.    Tenant
becoming insolvent, making a transfer in fraud of creditors, or making an assignment for the benefit of creditors. 

        C.    Tenant
filing a petition under any bankruptcy law of the United States or any state, or Tenant being placed in bankruptcy proceedings or adjudged bankrupt or insolvent in
proceedings filed against Tenant. 

        D.    Receiver
or trustee or similar officer being appointed for all or substantially all of Tenant's assets. 

        E.    Tenant
failing to comply with any other term, provision or covenant of this Lease and not curing such within ten (10) days after written notice thereof. However,
if such default is not curable within ten (10) days, Tenants must be making a good faith, diligent effort to cure said default and as soon as possible. 

        19.    LANDLORD'S REMEDIES:    If Tenant defaults Landlord may pursue
any one or more of the following remedies without any notice or demand whatsoever: 

        A.    Terminate
the Lease. In such event, Tenant shall immediately surrender the Demised Premises to Landlord. If Tenant fails to do so, Landlord may, without limiting any
other remedy which it may have for possession or arrearages in rent, enter upon and take possession of the Demised Premises and remove Tenant and any other person that may be occupying the Demised
Premises without being liable
for prosecution or any claim of damages therefrom. In such event, Tenant agrees to pay to Landlord on demand the amount of all loss and damage which Landlord may suffer by reason of such termination,
including without limitation Landlord's inability to relet the Demised Premises on terms satisfactory to Landlord. 

        B.    In
the event of a termination and removal as set forth herein, Landlord may: 

        1)    relet
the Demised Premises and receive rent therefor. Tenant shall pay to Landlord on demand any deficiency between rent under this Lease and the reletting. If Landlord
relets the Demised Premises at a greater rental, such excess shall be the sole property of Landlord, and Tenant hereby waives any claim to such relet excess rent; and 

        2)    perform
Tenant's obligations under the terms of this Lease. Tenants agrees to reimburse Landlord on demand for any expenses which Landlord incurs in fulfilling Tenant's
obligations with interest accruing on such amount at 12% per annum. 

        C.    Exercise
of any of the remedies set forth herein, or otherwise provided by law, shall not constitute a forfeiture or waiver of any rent or other payments due to Landlord,
or of any damages accruing to Landlord; nor shall any act of Landlord hereunder be deemed an acceptance of surrender of the Demised Premises. Only a writing signed by Landlord shall constitute a valid
acceptance of surrender of the Demised Premises. 

        D.    Landlord's
acceptance of any rent or other payments hereunder after a default by Tenant shall not be deemed a waiver of such default unless Landlord so notifies Tenant in
writing. Forbearance by Landlord to enforce a remedy shall not be a waiver of default or Landlord's right to enforce any remedy with respect to that default or any later default. Tenant shall pay
Landlord's reasonable attorneys fees in the enforcement or defense of any of Landlord's rights or remedies hereunder. 

11

 

        20.    MORTGAGE SUBORDINATION:    Tenant accepts this Lease subject
and subordinate to any mortgage(s), mortgage modifications, extensions and additions (collectively, "instruments") now or at any time hereafter constituting a lien or charge upon the Demised Premises
or improvements thereon. Tenant shall at any time hereafter and as often as requested to do so on demand execute any documents which may be required by any holder of an instrument for the purpose of
subjecting and subordinating this Lease to the lien of any such instrument. However, as a condition to executing any
subordination, Tenant shall receive from Mortgagee a covenant that as long as Tenant is not in default on Lease, Mortgagee will not disturb Tenant's leasehold interest in the Demised Premises. 

        21.    NEW OWNER:    If Landlord shall sell, assign, or convey its
right, title and interest in the Demised Premises to another (called herein "new owner"), this Lease shall continue in full force and effect; Tenant shall in all respects recognize the new owner as
its Landlord under this Lease, paying all rents and complying with all terms of this Lease. In such event, Landlord shall turn over Tenant's security deposit, if any, to the new owner. Landlord's
liability to return same to Tenant shall then cease, and the new owner shall then be obligated to return security deposit to Tenant subject to the terms and conditions of this Lease. The new owner
shall have all of Landlord's rights and shall assume all of Landlord's obligations hereunder. 

        22.    MECHANIC'S LIENS:    Tenant shall have no authority, express or
implied, to create, place or allow any lien or encumbrance of any kind or nature whatsoever upon, or in any manner to bind, the interest of Landlord in the Demised Premises. Payments under this Lease
shall not be chargeable by any third party, including any who may furnish materials or perform labor for any construction or repairs. Any claim or lien shall affect and attach to, if at all, only the
leasehold interest granted to Tenant by this agreement. Tenant shall pay all sums legally due and payable by it on account of any labor performed on the Demised Premises. Tenant shall indemnify and
hold Landlord harmless from any and all loss, costs or expense (including, without limitation, reasonable legal fees) based on or arising out of asserted claims or liens against the leasehold estate
or against the right, title and interest of Landlord in the Demised Premises. If a mechanic's lien attaches to the Demised Premises, Tenant shall take immediate action to obtain a bond or other surety
to remove the mechanic's lien from the Demised Premises. 

        23.    NOTICES:    Tenant shall send all rent or required notices by
hand-delivery or be registered mail to Landlord at Iowa State University Research Park Corporation, Suite 1600, 2501 North Loop Drive, Ames, Iowa
50010. Landlord shall provide any notice to Tenant by hand-delivery or registered mail at the address set forth on the title page hereof, or as Tenant may otherwise
designate in writing. Any notice or payment made shall be deemed delivered when actually received and not when deposited in the mail. 

        24.    BUSINESS INTERRUPTION:    Landlord shall not be responsible to
Tenant for any damages or inconvenience caused by interruption of business or inability to occupy the Demised Premises for any reason whatsoever. 

        25.    DELIVERY OF GOODS:    All deliveries to and shipments from
Tenant are the sole responsibility of Tenant. Tenant shall provide that such do not disrupt any other tenant of the Park. Landlord, in its sole discretion, may reasonably regulate such deliveries and
shipments to prevent disturbance to other tenants of the Park. 

        26.    NONDISCRIMINATION:    Tenant shall not discriminate against any
employee or applicant for employment because of race, color, religion, sex or national origin or in any other way prohibited by law. Tenant shall act affirmatively to ensure that applicants are
employed, and employees treated during employment, without regard to race, color, religion, sex or national origin or other discrimination prohibited by law. Such nondiscrimination shall include,
without limitation: employment, promotion, demotion, transfer, recruitment, advertising, lay-off, termination, rates of pay or other forms of compensation, selection of training, including
apprenticeship. 

12

 

        27.    LANDLORD REFUSAL TO CONSENT:    If Landlord is required to give
reasonable consent in any matter hereunder (rather than such consent being in Landlord's sole discretion), and Landlord refuses to consent, Tenant's sole remedy shall be to apply to an appropriate
court to request that Landlord be directed to give its consent. Tenant agrees not to make any claim against Landlord for money or subtract any sum from rent based on Landlord's refusal to consent. 

        28.    ENTIRE AGREEMENT:    Both parties have read this Lease and
understand that it sets forth their entire agreement. This Lease may be changed only by an agreement in writing duly signed and acknowledged and delivered to each party. 

        29.    CAPTIONS, DELETIONS, DEFINITIONS:    Headings and captions used
in this Lease are for the convenience of reference only, and are not deemed to modify any of the legal rights of the parties, such deletion may not be used in interpreting the rights of the parties
hereunder. Each party shall then have all rights which it would have had, at law or otherwise, as if such deleted provision had never been a part hereof. 

13

 
 

 

										
	 	 
	 	 
	 	 
	 	 
	 	 

	 	 TENANT	 	 	 	LANDLORD
	
 	
 NewLink Genetics, Inc.	
 	
 	
 	
Iowa State University
	 	 	 	 	 	 	 	Research Park Corporation
	
 	
 BY:	
 	
/s/ Gregory Compton

 	
 	
 	
 	
BY:	
 	
/s/ John B. Parks

 
	
 	
 POSITION:	
 	
President

 	
 	
 	
 	
POSITION:	
 	
President

 
	
 	
 DATED:	
 	
May 23, 2000

 	
 	
 	
 	
DATED:	
 	
5-25-00

 
	
 	
 BY:	
 	
  

 	
 	
 	
 	
BY:	
 	
    

 
	
 	
 POSITION:	
 	
  

 	
 	
 	
 	
POSITION:	
 	
    

 
	
 	
 DATED:	
 	
  

 	
 	
 	
 	
DATED:	
 	
    

 

 

 14

 

  
STATE OF IOWA)

                              ) SS:

COUNTY OF Story) 

        On
this 23 day of May, 2000, before me, the undersigned, a Notary Public in and for said county and state, personally appeared Greg Compton
and                    , to me personally known,
who being by me duly sworn, did say that they are the President and NA, respectively, of said corporation executing the within and foregoing instrument, that (no seal has been procured by the said)
(the seal affixed thereto is the seal of said) corporation; that said instrument was signed (and sealed) on behalf of said corporation by authority of its Board of Directors; and that the said Greg
Compton and NA as such officers acknowledged the execution of said instrument to be the voluntary act and deed of said corporation by it and by them voluntarily executed. 

 

 

			
	 	 	/s/ Mary Ann Black

  Notary Public in and for said County and State

 

 

  

STATE
OF IOWA)

                              ) SS:

COUNTY OF Story) 

        On
this 25 day of May, 2000, before me, the undersigned, a Notary Public in and for said county and state, personally appeared John Parks
and                    , to me personally known, who
being by me duly sworn, did say that they are the President and                    , respectively, of said corporation executing the within and
foregoing instrument, that (no seal has been procured by the
said) (the seal affixed thereto is the seal of said) corporation; that said instrument was signed (and sealed) on behalf of said corporation by authority of its Board of Directors; and that the said
John Parks and                   as such officers acknowledged the execution of said instrument to be the voluntary act and deed of said corporation by it
and by them voluntarily executed. 

 

 

			
	 	 	/s/ [illegible]

  Notary Public in and for said County and State

 

                   (Seal)

15

 

 
 

  ATTACHMENT 1    
    

 
    NEWLINK GENETICS, INC.    
    

±3,990 gross square feet

Suite 3900

Wayne R. Moore Technology Transfer Center #3

TYPICAL

  

16

 

 
 

  ATTACHMENT 2    
    

 
    NEWLINK GENETICS, INC.    
    

±3,990 gross square feet

Suite 3900

Wayne R. Moore Technology Transfer Center #3

 

 

																				
	 
	 	Square Feet 	 	 
	 	 
	 	 
	 	 
	 
	 
	 	Monthly

Base 	 	Monthly

Operating 	 	Yearly

Base 	 	Yearly

Operating 	 
	Term

 
	 	Base 	 	Operating 	 
	 

 9/1/2000
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 

 8/31/2001
	 	$	11.50	 	$	1.00	*	$	3,823.75	 	$	332.50	 	$	45,885.00	 	$	3,990.00	 
	 9/1/2001
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 8/31/2002
	 	$	12.50	 	$	2.00	*	$	4,156.25	 	$	665.00	 	$	49,875.00	 	$	7,980.00	 
	 

 9/1/2002
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 

 8/31/2003
	 	$	13.00	 	 	Actual	 	$	4,322.50	 	 	Actual	 	$	51,870.00	 	 	Actual	 
	 9/1/2003
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 8/31/2004
	 	$	13.50	 	 	Actual	 	$	4,488.75	 	 	Actual	 	$	53,865.00	 	 	Actual	 
	 

 9/1/2004
	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 
	 

 8/31/2005
	 	$	14.50	 	 	Actual	 	$	4,821.25	 	 	Actual	 	$	57,855.00	 	 	Actual	 

 

 

	(*)
	Estimated
operating costs. 

        Landlord
agrees to pay $174,696 of the estimated tenant finish costs for Suite 3900. Tenant will pay tenant finish costs in excess of this amount, currently estimated at $93,780.
Landlord agrees to finance Tenant's improvement costs up to $93,780 to be charged as additional rent. Landlord will amortize the improvements over a 10-year term for an additional
$1,132.87 per month (see Amortization Schedule) with a recapture provision for the balance of the loan due at the end of the five-year lease term. (The above example assumes a 7.90%
interest rate. Actual amount will be based on rate received from lender.) Other amenities provided by Landlord in the wet-lab area include the use of a conference room, a breakroom, other
shared lab facilities, vacuum system, and shared equipment. 

        As
security for these improvements, Landlord will require a letter of credit in the amount of $50,000 for the term of the lease until Tenant has secured $1 million in equity
investment from private placement offering. 

        Landlord
estimates that Suite 3900 will be completed by August 31, 2000. Should the suite not be completed by this date, this five-year term will begin upon its
completion of the building. 

        Gas
and water usage, as well as utility costs for the HVAC system, will be prorated and invoiced monthly. Electricity is metered separately and will be invoiced directly from the
provider. 

 

 17

 

 
 

  Exempt Amounts of Hazardous Materials Presenting a Physical Hazard
  Maximum Quantities Per Laboratory    
    

 

 

							
	MATERIAL

 
	 	CLASS 	 	OPEN SYSTEM—

SOLID LBS. (Cu. Ft.) 	 	OPEN SYSTEM—

LIQUID

GALLONS (LBS.) 
	 

 Combustible liquid(1)
	 	II	 	N.A.	 	30
	 

	 	III-A	 	 	 	80
	 

	 	III-B	 	 	 	3300(3)
	 Cryogenic (flammable or oxidizing)
	 	—	 	N.A.	 	10
	 

 Explosives
	 	—	 	1/4(4)	 	(1/4)(4)
	 Flammable Solid
	 	—	 	Not Allowed	 	N.A.
	 

 Flammable Gas
	 	—	 	N.A.	 	N.A.
	 Flammable Liquid(1)
	 	I-A	 	N.A.	 	10
	 Combination I-A, I-B, I-C
	 	I-B	 	N.A.	 	15
	 
	 	I-C	 	N.A.	 	20
	 
	 	 	 	N.A.	 	30
	 

 Organic Peroxide, unclassified, detonatable
	 	—	 	1/4(4)	 	(1/4)(4)
	 Organic Peroxide
	 	I	 	1(1)	 	1(1)
	 
	 	II	 	10(1)	 	(10)(1)
	 
	 	III	 	25(1)	 	(25)(1)
	 
	 	IV	 	100(1)	 	(100)(1)
	 
	 	V	 	Not Limited	 	Not Limited
	 

 Oxidizer
	 	4	 	1/4(4)	 	(1/4)(4)
	 

	 	3	 	2(1)	 	(2)(1)
	 

	 	2	 	50(1)	 	(50)(1)
	 

	 	1	 	1000(1)	 	(1000)(1)
	 Oxidizer—Gas(1)
	 	—	 	N.A.	 	N.A.
	 

 Pyrophoric
	 	—	 	0	 	0
	 Unstable (Reactive)
	 	4	 	1/4(4)	 	(1/4)(4)
	 
	 	3	 	1(1)	 	(1)(1)
	 
	 	2	 	10(1)	 	(10)(1)
	 
	 	1	 	Not Limited	 	Not Limited
	 

 Water Reactive
	 	3	 	1(1)	 	(1)(1)
	 

	 	2	 	10(1)	 	(10)(1)
	 

	 	1	 	25(3)	 	(25)(3)
	 Biohazard Level 3 & 4 Agents
	 	None	 	None	 	None

 

 

	(1)
	Quantities
may be increased 100 percent in sprinklered buildings. When footnote 3 also applies, the increase for both footnotes may be applied.

	(2)
	Quantities
may be increased by 100 percent when stored in approved storage cabinets, gas cabinets or exhausted enclosures. When footnote 2 also
applies, the increase for both footnotes may be applied.

	(3)
	The
quantities permitted in a sprinklered building are not limited.

	(4)
	Permitted
in sprinklered buildings only. None is allowed in unsprinklered buildings. 

 

 

 

 

				
	 Combustible Liquid—
	 	 
	 	 Class II—
	 	 Acetic Acid, Acetic Anhydride, Acrylic Acid, Benzenethiol, Formic Acid, Kerosene, Naphtha, Vinyl Toluene

	 	 Class III-A—
	 	Aniline, Benzyl Chloride, Chloroacetaldehyde, Cyclohexanone, Diazinon, Dimethyl Sulfate, Divinyl Benzene, Ethanolamine, Formalin, Nitrobenzene
	 	 Class III-B—
	 	Diethanolamine, Ethylene Glycol, Formamide, Glycerin, Malathion, Parathion, Resorcinol
	 Cryogenic Fluids—
	 	 Flammable (Carbon monoxide, Deuterium, Ethylene, Hydrogen, Methane)

Oxidizer (Fluorine, Nitric Oxide, Oxygen)

	 Explosives—
	 	 Black Powder, Dynamite, Nitrocellulose, Nitroglycerine

	 Flammable Solid—
	 	 Camphor, Cellulose Nitrate, Napthalene, Decaborane, Lithium Amide, Potassium Sulfide, Sulfur, Combustible Metals (Cesium,
Magnesium and Zirconium)

	 Flammable Gas—
	 	 Acetylene, Arsine, Carbon Monoxide, Cyanogen, Diborane, Ethane, Ethylene, Formaldehyde, Hydrogen, Hydrogen Sulfide, LP Gas,
Methane, Phosphine, Vinyl Chloride

	 Flammable Liquid—
	 	 
	 	 Class I-A—
	 	 Acetaldehyde, n-Butane, Dimethylamine, Ethylamine, Ethyl Chloride, Ethylene Oxide Ethyl Ether, Ethyl Mercaptan, Hydrogen Cyanide,
Isobutane, Pentane, Vinyl Bromide,

	 	 Class I-B—
	 	Acetone, Acetonitrile, Acrolein, Acrylonitrile, Benzene, tert-Butyl Alcohol, Carbon Disulfide, Cyclohexane, Diethylamine, Dioxane, Ethyl Acetate, Ethyl Alcohol, Gasoline, Heptane, Hexane, Isopropyl Acetate, Isopropyl
Alcohol, Methyl Alcohol, Octane, Propionitrile, Propanol, Pyridine, Tetrahydrofuran, Toluene, Triethylamine, Vinyl Acetate
	 	 Class I-C—
	 	sec-Butyl Alcohol, Chlorobenzene, Cumene, Ethylenediamine, Hydrazine, Isoamyl Acetate, Nonane, Styrene, Turpentine, o-Xylene
	 Organic Peroxide (Unclassified, Detonatable)—

	 Organic Peroxide—
	 	 
	 	 Class I—
	 	 Acetyl Cyclohexane Sulfonyl 60-65%, Fulfonyl Peroxide, Benzoyl Peroxide over 98%, t-butyl hydroperoxide 90%

	 	 Class II—
	 	Acetyl Peroxide 25%, Peroxyacetic Acid 43%
	 	 Class III—
	 	Benzoyl Peroxide 78%,
	 	 Class IV—
	 	Benzoyl Peroxide 70%,
	 	 Class V—
	 	Benzoyl Peroxide 35%, 1,1-di-t-butyl peroxy 3,5,5-trimethylcyclonehexane 40%
	 Oxidizer—
	 	 
	 	 Class 4—
	 	 Ammonium Perchlorate, Ammonium Permanganate, Tetranitromethane

	 	 Class 3—
	 	Ammonium Dichlorate, Calcium Hypochlorite, Potassium Bromate, Potassium Chlorate, Sodium Bromate, Sodium Chlorate
	 	 Class 2—
	 	Barium Bromate, Barium Chlorate, Calcium Perchlorate, Lithium Perchlorate, Magnesium Perchlorate, Sodium Permanganate
	 	 Class 1—
	 	Inorganic Nitrates, Inorganic Nitrites, Ammonium Persulfate, Lithium Peroxide, Manganese Dioxide, Zinc Peroxide
	 Oxidizer (Gas)—
	 	 Oxygen, Ozone, Oxides of Nitrogen Fluorine and Chlorine

 

 

 

 

				
	 Pyrophoric—
	 	 Gases (Diborane, Phosphine, Silane)

Solids (Cesium, hafnium, Lithium, White or Yellow Phosphorus, Plutonium, Potassium, Sodium)

Liquids (Diethyl Aluminum Chloride, Diethyl Beryllium, Diethyl Phosphine)

	 Unstable (Reactive)—
	 	 
	 	 Class 4—
	 	 Acetyl Peroxide, Dibutyl Peroxide, Ethyl Nitrate, Picric Acid Trinitrobenzene, Peroxyacetic Acid

	 	 Class 3—
	 	Hydrogen Peroxide greater than 52%, Hydroxylamine, Nitromethane, Perchloric Acid
	 	 Class 2—
	 	Acrolein, Acrylic Acid, Hydrazine, Sodium Perchlorate, Styrene, Vinyl Acetate
	 	 Class 1—
	 	Acetic Acid, Hydrogen Peroxide 35% to 52%, Paraldehyde, Tetrahydrofuran
	 Water Reactive—
	 	 
	 	 Class 3—
	 	 Bromine Pentafluoride, Isobutylaluminum, Triethylaluminum,

	 	 Class 2—
	 	Calcium Carbide, Calcium Metal, Lithium Hydride, Sodium Metal, Sodium Peroxide Trichlorosilane
	 	 Class 1—
	 	Acetic Anhydride, Sodium Hydroxide, Sulfur Monochloride, Titanium Tetrachloride

 

  Amortization Schedule—NewLink  

 

 

					
	 Amount to be financed
	 	 	93,780.00	 
	 Interest Rate
	 	 	7.90	%
	 Monthly Payment
	 	 	1,132.87	 
	 Term
	 	 	10 Years	 
	 Total number of Payments
	 	 	120	 
	 Principal balance at the end of 5 years
	 	 	56,003	 
	 Principal balance at the end of 10 years
	 	 	(1	)

 

         Tenant
will be billed at the beginning of each month with monthly lease billings. 

        Billings
will be for the upcoming month. 

 

 

																	
	Pmt#

 
	 	Date 	 	Payment

Beginning Balance 	 	Principal 	 	Interest 	 	Balance 	 
	 
	 	 	5/1/00	 	 	 	 	 	 	 	 	 	 	 	93,780.00	 
	 1
	 	 	6/1/00	 	$	1,132.87	 	$	515.48	 	$	617.39	 	 	93,264.52	 
	 2
	 	 	7/1/00	 	$	1,132.87	 	$	518.87	 	$	613.99	 	 	92,745.64	 
	 3
	 	 	8/1/00	 	 	1,132.87	 	$	522.29	 	$	610.58	 	 	92,223.35	 
	 4
	 	 	9/1/00	 	 	1,132.87	 	$	525.73	 	$	607.14	 	 	91,697.62	 
	 5
	 	 	10/1/00	 	 	1,132.87	 	$	529.19	 	$	603.68	 	 	91,168.43	 
	 6
	 	 	11/1/00	 	 	1,132.87	 	$	532.67	 	$	600.19	 	 	90,635.76	 
	 7
	 	 	12/1/00	 	 	1,132.87	 	$	536.18	 	$	596.69	 	 	90,099.58	 
	 8
	 	 	1/1/01	 	 	1,132.87	 	$	539.71	 	$	593.16	 	 	89,559.87	 
	 9
	 	 	2/1/01	 	 	1,132.87	 	$	543.26	 	$	589.60	 	 	89,016.60	 
	 10
	 	 	3/1/01	 	 	1,132.87	 	$	546.84	 	$	586.03	 	 	88,469.76	 
	 11
	 	 	4/1/01	 	 	1,132.87	 	$	550.44	 	$	582.43	 	 	87,919.32	 
	 12
	 	 	5/1/01	 	 	1,132.87	 	$	554.06	 	$	578.80	 	 	87,365.26	 
	 13
	 	 	6/1/01	 	 	1,132.87	 	$	557.71	 	$	575.15	 	 	86,807.55	 
	 14
	 	 	7/1/01	 	 	1,132.87	 	$	561.38	 	$	571.48	 	 	86,246.16	 
	 15
	 	 	8/1/01	 	 	1,132.87	 	$	565.08	 	$	567.79	 	 	85,681.08	 
	 16
	 	 	9/1/01	 	 	1,132.87	 	$	568.80	 	$	564.07	 	 	85,112.28	 
	 17
	 	 	10/1/01	 	 	1,132.87	 	$	572.54	 	$	560.32	 	 	84,539.74	 
	 18
	 	 	11/1/01	 	 	1,132.87	 	$	576.31	 	$	556.55	 	 	83,963.43	 

 

 

 

 

																	
	Pmt#

 
	 	Date 	 	Payment

Beginning Balance 	 	Principal 	 	Interest 	 	Balance 	 
	 19
	 	 	12/1/01	 	 	1,132.87	 	$	580.11	 	$	552.76	 	 	83,383.32	 
	 20
	 	 	1/1/02	 	 	1,132.87	 	$	583.93	 	$	548.94	 	 	82,799.39	 
	 21
	 	 	2/1/02	 	 	1,132.87	 	$	587.77	 	$	545.10	 	 	82,211.62	 
	 22
	 	 	3/1/02	 	 	1,132.87	 	$	591.64	 	$	541.23	 	 	81,619.98	 
	 23
	 	 	4/1/02	 	 	1,132.87	 	$	595.53	 	$	537.33	 	 	81,024.45	 
	 24
	 	 	5/1/02	 	 	1,132.87	 	$	599.46	 	$	533.41	 	 	80,424.99	 
	 25
	 	 	6/1/02	 	 	1,132.87	 	$	603.40	 	$	529.46	 	 	79,821.59	 
	 26
	 	 	7/1/02	 	 	1,132.87	 	$	607.37	 	$	525.49	 	 	79,214.22	 
	 27
	 	 	8/1/02	 	 	1,132.87	 	$	611.37	 	$	521.49	 	 	78,602.84	 
	 28
	 	 	9/1/02	 	 	1,132.87	 	$	615.40	 	$	517.47	 	 	77,987.45	 
	 29
	 	 	10/1/02	 	 	1,132.87	 	$	619.45	 	$	513.42	 	 	77,368.00	 
	 30
	 	 	11/1/02	 	 	1,132.87	 	$	623.53	 	$	509.34	 	 	76,744.47	 
	 31
	 	 	12/1/02	 	 	1,132.87	 	$	627.63	 	$	505.23	 	 	76,116.84	 
	 32
	 	 	1/1/03	 	 	1,132.87	 	$	631.76	 	$	501.10	 	 	75,485.08	 
	 33
	 	 	2/1/03	 	 	1,132.87	 	$	635.92	 	$	496.94	 	 	74,849.15	 
	 34
	 	 	3/1/03	 	 	1,132.87	 	$	640.11	 	$	492.76	 	 	74,209.04	 
	 35
	 	 	4/1/03	 	 	1,132.87	 	$	644.32	 	$	488.54	 	 	73,564.72	 
	 36
	 	 	5/1/03	 	 	1,132.87	 	$	648.57	 	$	484.30	 	 	72,916.15	 
	 37
	 	 	6/1/03	 	 	1,132.87	 	$	652.84	 	$	480.03	 	 	72,263.32	 
	 38
	 	 	7/1/03	 	 	1,132.87	 	$	657.13	 	$	475.73	 	 	71,606.19	 
	 39
	 	 	8/1/03	 	 	1,132.87	 	$	661.46	 	$	471.41	 	 	70,944.73	 
	 40
	 	 	9/1/03	 	 	1,132.87	 	$	665.81	 	$	467.05	 	 	70,278.91	 
	 41
	 	 	10/1/03	 	 	1,132.87	 	$	670.20	 	$	462.67	 	 	69,608.72	 
	 42
	 	 	11/1/03	 	 	1,132.87	 	$	674.61	 	$	458.26	 	 	68,934.11	 
	 43
	 	 	12/1/03	 	 	1,132.87	 	$	679.05	 	$	453.82	 	 	68,255.06	 
	 44
	 	 	1/1/04	 	 	1,132.87	 	$	683.52	 	$	449.35	 	 	67,571.54	 
	 45
	 	 	2/1/04	 	 	1,132.87	 	$	688.02	 	$	444.85	 	 	66,883.52	 
	 46
	 	 	3/1/04	 	 	1,132.87	 	$	692.55	 	$	440.32	 	 	66,190.97	 
	 47
	 	 	4/1/04	 	 	1,132.87	 	$	697.11	 	$	435.76	 	 	65,493.86	 
	 48
	 	 	5/1/04	 	 	1,132.87	 	$	701.70	 	$	431.17	 	 	64,792.16	 
	 49
	 	 	6/1/04	 	 	1,132.87	 	$	706.32	 	$	426.55	 	 	64,085.84	 
	 50
	 	 	7/1/04	 	 	1,132.87	 	$	710.97	 	$	421.90	 	 	63,374.87	 
	 51
	 	 	8/1/04	 	 	1,132.87	 	$	715.65	 	$	417.22	 	 	62,659.22	 
	 52
	 	 	9/1/04	 	 	1,132.87	 	$	720.36	 	$	412.51	 	 	61,938.86	 
	 53
	 	 	10/1/04	 	 	1,132.87	 	$	725.10	 	$	407.76	 	 	61,213.76	 
	 54
	 	 	11/1/04	 	 	1,132.87	 	$	729.88	 	$	402.99	 	 	60,483.89	 
	 55
	 	 	12/1/04	 	 	1,132.87	 	$	734.68	 	$	398.19	 	 	59,749.21	 
	 56
	 	 	1/1/05	 	 	1,132.87	 	$	739.52	 	$	393.35	 	 	59,009.69	 
	 57
	 	 	2/1/05	 	 	1,132.87	 	$	744.39	 	$	388.48	 	 	58,265.30	 
	 58
	 	 	3/1/05	 	 	1,132.87	 	$	749.29	 	$	383.58	 	 	57,516.02	 
	 59
	 	 	4/1/05	 	 	1,132.87	 	$	754.22	 	$	378.65	 	 	56,761.80	 
	 60
	 	 	5/1/05	 	 	1,132.87	 	$	759.18	 	$	373.68	 	 	56,002.61	 
	 61
	 	 	6/1/05	 	 	1,132.87	 	$	764.18	 	$	368.68	 	 	55,238.43	 
	 62
	 	 	7/1/05	 	 	1,132.87	 	$	769.21	 	$	363.65	 	 	54,469.22	 
	 63
	 	 	8/1/05	 	 	1,132.87	 	$	774.28	 	$	358.59	 	 	53,694.94	 
	 64
	 	 	9/1/05	 	 	1,132.87	 	$	779.37	 	$	353.49	 	 	52,915.56	 
	 65
	 	 	10/1/05	 	 	1,132.87	 	$	784.51	 	$	348.36	 	 	52,131.06	 
	 66
	 	 	11/1/05	 	 	1,132.87	 	$	789.67	 	$	343.20	 	 	51,341.39	 
	 67
	 	 	12/1/05	 	 	1,132.87	 	$	794.87	 	$	338.00	 	 	50,346.32	 
	 68
	 	 	1/1/06	 	 	1,132.87	 	$	800.10	 	$	332.76	 	 	49,746.42	 
	 69
	 	 	2/1/06	 	 	1,132.87	 	$	805.37	 	$	327.50	 	 	48,941.05	 
	 70
	 	 	3/1/06	 	 	1,132.87	 	$	810.67	 	$	322.20	 	 	48,130.38	 

 

 

 

 

																	
	Pmt#

 
	 	Date 	 	Payment

Beginning Balance 	 	Principal 	 	Interest 	 	Balance 	 
	 71
	 	 	4/1/06	 	 	1,132.87	 	$	816.01	 	$	316.86	 	 	47,314.37	 
	 72
	 	 	5/1/06	 	 	1,132.87	 	$	821.38	 	$	311.49	 	 	46,492.99	 
	 73
	 	 	6/1/06	 	 	1,132.87	 	$	826.79	 	$	306.08	 	 	45,666.20	 
	 74
	 	 	7/1/06	 	 	1,132.87	 	$	832.23	 	$	300.64	 	 	44,833.97	 
	 75
	 	 	8/1/06	 	 	1,132.87	 	$	837.71	 	$	295.16	 	 	43,996.26	 
	 76
	 	 	9/1/06	 	 	1,132.87	 	$	843.22	 	$	289.64	 	 	43,153.04	 
	 77
	 	 	10/1/06	 	 	1,132.87	 	$	848.78	 	$	284.09	 	 	42,304.26	 
	 78
	 	 	11/1/06	 	 	1,132.87	 	$	854.36	 	$	278.50	 	 	41,449.90	 
	 79
	 	 	12/1/06	 	 	1,132.87	 	$	859.99	 	$	272.88	 	 	40,589.91	 
	 80
	 	 	1/1/07	 	 	1,132.87	 	$	865.65	 	$	267.22	 	 	39,724.26	 
	 81
	 	 	2/1/07	 	 	1,132.87	 	$	871.35	 	$	261.52	 	 	38,852.91	 
	 82
	 	 	3/1/07	 	 	1,132.87	 	$	877.08	 	$	255.78	 	 	37,975.83	 
	 83
	 	 	4/1/07	 	 	1,132.87	 	$	882.86	 	$	250.01	 	 	37,092.97	 
	 84
	 	 	5/1/07	 	 	1,132.87	 	$	888.67	 	$	244.20	 	 	36,204.30	 
	 85
	 	 	6/1/07	 	 	1,132.87	 	$	894.52	 	$	238.34	 	 	35,309.78	 
	 86
	 	 	7/1/07	 	 	1,132.87	 	$	900.41	 	$	232.46	 	 	34,409.37	 
	 87
	 	 	8/1/07	 	 	1,132.87	 	$	906.34	 	$	226.53	 	 	33,503.03	 
	 88
	 	 	9/1/07	 	 	1,132.87	 	$	912.30	 	$	220.56	 	 	32,590.72	 
	 89
	 	 	10/1/07	 	 	1,132.87	 	$	918.31	 	$	214.56	 	 	31,672.41	 
	 90
	 	 	11/1/07	 	 	1,132.87	 	$	924.36	 	$	208.51	 	 	30,748.06	 
	 91
	 	 	12/1/07	 	 	1,132.87	 	$	930.44	 	$	202.42	 	 	29,817.61	 
	 92
	 	 	1/1/08	 	 	1,132.87	 	$	936.57	 	$	196.30	 	 	28,881.05	 
	 93
	 	 	2/1/08	 	 	1,132.87	 	$	942.73	 	$	190.13	 	 	27,938.31	 
	 94
	 	 	3/1/08	 	 	1,132.87	 	$	948.94	 	$	183.93	 	 	26,989.38	 
	 95
	 	 	4/1/08	 	 	1,132.87	 	$	955.19	 	$	177.68	 	 	26,034.19	 
	 96
	 	 	5/1/08	 	 	1,132.87	 	$	961.47	 	$	171.39	 	 	25,072.71	 
	 97
	 	 	6/1/08	 	 	1,132.87	 	$	967.80	 	$	165.06	 	 	24,104.91	 
	 98
	 	 	7/1/08	 	 	1,132.87	 	$	974.18	 	$	158.69	 	 	23,130.73	 
	 99
	 	 	8/1/08	 	 	1,132.87	 	$	980.59	 	$	152.28	 	 	22,150.15	 
	 100
	 	 	9/1/08	 	 	1,132.87	 	$	987.04	 	$	145.82	 	 	21,163.10	 
	 101
	 	 	10/1/08	 	 	1,132.87	 	$	993.54	 	$	139.32	 	 	20,169.56	 
	 102
	 	 	11/1/08	 	 	1,132.87	 	$	1,000.08	 	$	132.78	 	 	19,169.47	 
	 103
	 	 	12/1/08	 	 	1,132.87	 	$	1,006.67	 	$	126.20	 	 	18,162.81	 
	 104
	 	 	1/1/09	 	 	1,132.87	 	$	1,013.29	 	$	119.57	 	 	17,149.51	 
	 105
	 	 	2/1/09	 	 	1,132.87	 	$	1,019.97	 	$	112.90	 	 	16,129.55	 
	 106
	 	 	3/1/09	 	 	1,131.87	 	$	1,026.68	 	$	106.19	 	 	15,102.87	 
	 107
	 	 	4/1/09	 	 	1,132.87	 	$	1,033.44	 	$	99.43	 	 	14,069.43	 
	 108
	 	 	5/1/09	 	 	1,132.87	 	$	1,040.24	 	$	92.62	 	 	13,029.19	 
	 109
	 	 	6/1/09	 	 	1,132.87	 	$	1,047.09	 	$	85.78	 	 	11,982.09	 
	 110
	 	 	7/1/09	 	 	1,132.87	 	$	1,053.98	 	$	78.88	 	 	10,928.11	 
	 111
	 	 	8/1/09	 	 	1,132.87	 	$	1,060.92	 	$	71.94	 	 	9,867.19	 
	 112
	 	 	9/1/09	 	 	1,132.87	 	$	1,067.91	 	$	64.96	 	 	8,799.28	 
	 113
	 	 	10/1/09	 	 	1,132.87	 	$	1,074.94	 	$	57.93	 	 	7,724.34	 
	 114
	 	 	11/1/09	 	 	1,132.87	 	$	1,082.01	 	$	50.85	 	 	6,642.33	 
	 115
	 	 	12/1/09	 	 	1,132.87	 	$	1,089.14	 	$	43.73	 	 	5,553.19	 
	 116
	 	 	1/1/10	 	 	1,132.87	 	$	1,096.31	 	$	36.56	 	 	4,456.88	 
	 117
	 	 	2/1/10	 	 	1,132.87	 	$	1,103.53	 	$	29.34	 	 	3,353.36	 
	 118
	 	 	3/1/10	 	 	1,132.87	 	$	1,110.79	 	$	22.08	 	 	2,242.57	 
	 119
	 	 	4/1/10	 	 	1,132.87	 	$	1,118.10	 	$	14.76	 	 	1,124.46	 
	 120
	 	 	5/1/10	 	 	1,132.87	 	$	1,125.46	 	$	7.40	 	 	(1.00	)

 

 

QuickLinks

Exhibit 10.46

NewLink Genetics, Inc. Suite 3900 2901 South Loop Drive Ames, IA 50010

TABLE OF CONTENTS

SUMMARY PAGE

LEASE

ATTACHMENT 1

NEWLINK GENETICS, INC.

ATTACHMENT 2

NEWLINK GENETICS, INC.

Exempt Amounts of Hazardous Materials Presenting a Physical Hazard Maximum Quantities Per LaboratoryUse these links to rapidly review the document

  TABLE OF CONTENTS

 

 

 
 

  Exhibit 10.47    
    

 
  IOWA STATE INNOVATION SYSTEM    
    
    SUBLEASE AGREEMENT    
    
    ****    
    
    NewLink Genetics, Inc.    
    
    February 1,
2001 - January 31, 2002    

1

 

 

  TABLE OF CONTENTS    
    

 

 

 

							
	 
	 	 
	 	PAGE 	 
	 1.
	 	 Premises
	 	 	3	 
	 2.
	 	 Sublease Term
	 	 	

3	 
	 3.
	 	 Renewal
	 	 	

3	 
	 4.
	 	 Possession
	 	 	

3	 
	 6.
	 	 Use of Property
	 	 	

3	 
	 7.
	 	 Care of Premises
	 	 	

4	 
	 8.
	 	 Utilities and Services
	 	 	

4	 
	 9.
	 	 Insurance
	 	 	

4	 
	 10.
	 	 Liability
	 	 	

4	 
	 11.
	 	 Holding Over
	 	 	

4	 
	 12.
	 	 Rules
	 	 	

5	 
	 13.
	 	 Representations
	 	 	

5	 
	 14.
	 	 Assignment
	 	 	

5	 
	 15.
	 	 Inspections
	 	 	

5	 
	 16.
	 	 Remedies
	 	 	

5	 
	 17.
	 	 Changes In Writing
	 	 	

5	 
	 18.
	 	 Common Areas
	 	 	

5	 
	 19.
	 	 Security
	 	 	

5	 
	 20.
	 	 Relocation
	 	 	

5	 
	 21.
	 	 Ratification by Signature
	 	 	

6	 
	 22.
	 	 Attachment 1
	 	 	

7	 

 

 2

 

 
 

  Sublease Between
  IOWA STATE INNOVATION SYSTEM
  and
  NewLink Genetics, Inc.
  an Iowa Company    
    

        Iowa
State University of Science and Technology and the Board of Regents, State of Iowa have entered into a lease agreement with the Iowa State University Research Park Corporation for
multi-tenant space commonly referred to as Iowa State Innovation System (ISIS), in the Iowa State University Research Park Corporation building located at 2501 North Loop Drive, Ames, Iowa. The Board
of Regents, State of Iowa and Iowa State University of Science and Technology are authorized to sublease space within the ISIS Center for approved uses. 

        THIS
SUBLEASE AGREEMENT MADE AND ENTERED INTO THIS 24th day of January 2001 by and between the Board of Regents, State of Iowa for the Use and Benefit of Iowa State University of
Science and Technology and Iowa State Innovation System, hereinafter referred to as the LESSEE, and NewLink Genetics, Inc., hereinafter referred to as the SUBLESSEE.  

	1.
	PREMISES:    The premises consists of approximately 165 and 110 square feet, respectively, of
office space, commonly referred to as Suite 3505 & 3510 in the building known as the Iowa State Innovation System Center (ISIS Wet-lab Incubator), located at 2901 South Loop
Drive. The premises are on the Iowa State University Research Park site in Ames, Iowa.

	2.
	SUBLEASE TERM:    The term of this sublease for Suite 3505 shall be a period of
12 months, commencing February 1, 2001 and ending January 31, 2002. The term of this sublease for Suite 3510 shall be on a month-to-month basis. It is
mutually agreed that this sublease may be terminated by either party upon thirty (30) days written notice to the other party. Prior to final execution of this document, SUBLESSEE may stage
equipment and conduct business at its own risk provided that it insures LESSEE pursuant to paragraph 9 of this lease.

	3.
	SUBLEASE PAYMENT:    Rent for the term of this sublease shall be in the amount of $500.00 per
month, payable in advance on the first day of the month.

	4.
	RENEWAL:    Continuation of the lease is contingent upon a review of the business progress of the
client by the director of ISIS. After a successful review, this sublease may be renewed on a month-to-month basis at a rental of $300.00 per month for Suite 3505 and $200.00
per month for Suite 3510.

	5.
	POSSESSION:    SUBLESSEE shall be entitled to possession on the first day of the term of this
sublease, and shall yield possession to LESSEE at the time and date of the close of the sublease term. All keys and other property of LESSEE shall be returned by SUBLESSEE at that time.

	6.
	USE OF PROPERTY:    This property shall be used by SUBLESSEE for office, applied research, product
development and marketing. SUBLESSEE shall submit in writing any proposed plan for changes, modifications or additions to the premises and will not proceed with same without LESSEE's written approval,
which shall not be unreasonably withheld. 

Without
Landlord's prior written consent, Tenant shall not receive, store or otherwise handle any hazardous substance (as defined below) on the Demised Premises. To the extent Landlord consents to the
presence of any hazardous substance on the Demised Premises, in no event shall any such hazardous substance be a substance that is: (i) included on the attached list of Hazardous Materials
Presenting a Physical Hazard in a quantity exceeding the maximum quantity allowed on such list; or (ii) a biological contaminant in excess of biohazard level 3 or 4 (see Attachment '1').
In addition, Tenant shall receive, store, use, and otherwise handle any such hazardous substance permitted on the Demised Premises in compliance with all applicable local, state, and federal 

3

 

environmental
protection ordinances, regulations, or laws (each an "environmental law"). For purposes of this SubLease, a hazardous substance shall include any substance that: (i) is or
contains asbestos, urea formaldehyde foam insulation, polychlorinated biphenyls, petroleum or petroleum derived substances or wastes, radon gas, or related materials; (ii) requires
investigation, removal, or remediation under any environmental under any environmental law, or is defined, listed, or identified as a "hazardous waste" or "hazardous substance" thereunder, or
(iii) is toxic, explosive, corrosive, flammable, infectious, radioactive, carcinogenic, mutagenic, or otherwise hazardous and is regulated by any governmental authority or environmental law. 

	7.
	CARE OF PREMISES:    SUBLESSEE shall keep the premises neat and orderly, and shall surrender the
premises at the end of the sublease term in the same condition as when it took possession, normal wear and tear excepted. SUBLESSEE shall ensure that its operation shall not create unreasonable noise,
interference or disruption for any other SUBLESSEE, or for the University.

	8.
	UTILITIES AND SERVICES:    General purpose water, heat, light, trash removal, maintenance and
general care of hallways and public areas will be provided by LESSEE. Should SUBLESSEE's operations result in excessive and inordinate utility consumption, LESSEE reserves the right to charge a
reasonable fee for such consumption. SUBLESSEE is responsible for telephone service and charges; as well as any secretarial and administrative services provided to SUBLESSEE based on the current costs
presented to SUBLESSEE at the date of this lease.

	9.
	INSURANCE:    LESSEE and SUBLESSEE shall each be responsible to protect its respective property
interests. SUBLESSEE shall obtain, at its own expense, and provide to the University, a general liability insurance certificate that includes the Iowa State University Research Park Corporation and
the Board of Regents, State of Iowa as additional insureds. The insurance companies providing coverage must be of an acceptable financial rating as determined by Iowa State University Risk Management.
The policy must provide the following coverage and limits as a minimum: $1,000,000 combined single limit per occurrence for bodily injury including death personal injury and property damage. 

The
term of coverage shall coincide with the dates of the agreement. The certificates shall provide 30 days notice of cancellation or material change of coverage to the certificate holders. 

	10.
	LIABILITY:    SUBLESSEE agrees to indemnify, defend and hold harmless LESSEE, Iowa State
University of Science and Technology, Board of Regents, State of Iowa and the Iowa State University Research Park Corporation and their respective officers, employees, agents and others from and
against any and all liability, loss, costs, damage and expenses occasioned by, or arising out of, SUBLESSEE's business operation, products or services, debts or obligations, or any action of
SUBLESSEE, its employees, agents and others, or any and all liability resulting from or arising out of the advice, services, or other aid provided to SUBLESSEE by the parties set forth above in this
section.

	11.
	HOLDING OVER:    Continued possession beyond the expiration date of the term of this sublease by
the SUBLESSEE shall constitute a month-to-month extension of this sublease.

	12.
	RULES:    SUBLESSEE understands and acknowledges that it and its officers, employees, agents,
visitors and guests shall observe all operating policies of the LESSEE, including, but not limited to, rules, procedures and traffic and parking regulations. Such policies shall be provided in writing
by LESSEE upon request of SUBLESSEE.

	13.
	REPRESENTATIONS:    SUBLESSEE agrees that it will not represent itself as acting on behalf of, or
as a part of, the LESSEE, Iowa State University of Science and Technology, Board of Regents, State of Iowa and Iowa State University Research Park Corporation. 

4

 
	14.
	ASSIGNMENT:    SUBLESSEE shall not assign or sublet this sublease or its rights hereunder to any
other party without the prior written approval of LESSEE.

	15.
	INSPECTION:    SUBLESSEE shall allow LESSEE to enter the leased premises at reasonable times, and
with reasonable notice considering the circumstances, for the purposes of inspection, repairs or improvements, or to show the premises to prospective sublessees.

	16.
	REMEDIES.    If SUBLESSEE fails to comply with the terms of this sublease, and refuses to correct
such non-compliance within 10 days following written notice, LESSEE may terminate this sublease and proceed to remove SUBLESSEE from the premises, or take such other action as is
provided by law.

	17.
	CHANGES IN WRITING:    Any and all changes, additions or deletions to the terms of this sublease
shall be in writing, executed by both parties.

	18.
	COMMON AREAS:    SUBLESSEE shall have reasonable use of common areas of the building for normal
business purposes, within the policy guidelines of ISIS Center. Common areas include the ISIS equipment room, tissue culture lab, dark room, conference room, shipping and receiving, copy room, break
area, hallways, and other designated common work areas.

	19.
	SECURITY:    SUBLESSEE is responsible for securing all windows and doors within and on its
subleased space, and shall exert diligence in keeping building entrances and openings locked after normal business hours.

	20.
	RELOCATION:    LESSEE reserves the right to relocate SUBLESSEE to a comparable space within the
incubator facility at LESSEE's discretion. LESSEE will provide 30 days notice prior to relocation. 

5

 
 

 

							
	SUBLESSEE:	 	 	 	 
	
 BY:	
 	
/s/ T. Seregina

 	
 	

 	
 	

 
	
 TITLE:	
 	
COO

 	
 	

 	
 	

 
	
 DATE:	
 	
01-30-01

 	
 	

 	
 	

 
	

 	
 	
Iowa State University

Vice President for

Business and Finance	
 	
 	
 	
Board of Regents, State of Iowa

for the Use and Benefit

of Iowa State University

of Science and Technology at Ames, Iowa.
	
 BY:	
 	
/s/ Warren Madden

  Warren Madden,

Vice President	
 	
BY:	
 	
/s/ Frank J. Stork

  Frank J. Stork,

Exclusive Director
	
 DATE:	
 	
3/23/01

 	
 	
DATE:	
 	
4/11/01

 
	
 AND	
 	

 	
 	

 	
 	

 
	
 LESSEE:	
 	
IOWA STATE INNOVATION SYSTEM
	
 BY:	
 	
/s/ Steven T. Carter

  Steven T. Carter,

Director	
 	

 	
 	

 
	
 DATE:	
 	
2/2/01

 	
 	

 	
 	

 

 

 6

 

 
 

  ATTACHMENT 1    
    

Exempt
Amounts of Hazardous Materials Presenting a Physical Hazard

Maximum Quantities Per Laboratory 

 

 

							
	MATERIAL

 
	 	CLASS 	 	OPEN SYSTEM—

SOLID LBS. (Cu. Ft.) 	 	OPEN SYSTEM—

LIQUID

GALLONS (LBS.) 
	 

 Combustible liquid(1)
	 	II	 	N.A.	 	30
	 

	 	III-A	 	 	 	80
	 

	 	III-B	 	 	 	3300(3)
	 Cryogenic (flammable or oxidizing)
	 	`````	 	N.A.	 	10
	 

 Explosives
	 	`````	 	1/4(4)	 	(1/4)(4)
	 Flammable Solid
	 	`````	 	Not Allowed	 	N.A.
	 

 Flammable Gas
	 	`````	 	N.A.	 	N.A.
	 Flammable Liquid(1)
	 	I-A	 	N.A.	 	10
	 Combination I-A, I-B, I-C
	 	I-B	 	N.A.	 	15
	 
	 	I-C	 	N.A.	 	20
	 
	 	 	 	N.A.	 	30
	 

 Organic Peroxide, unclassified, detonatable
	 	 	 	1/4(4)	 	(1/4)(4)
	 Organic Peroxide
	 	I	 	1(1)	 	1(1)
	 
	 	II	 	10(1)	 	(10)(1)
	 
	 	III	 	25(1)	 	(25)(1)
	 
	 	IV	 	100(1)	 	(100)(1)
	 
	 	V	 	Not Limited	 	Not Limited
	 

 Oxidizer
	 	4	 	1/4(4)	 	(1/4)(4)
	 

	 	3	 	2(1)	 	(2)(1)
	 

	 	2	 	50(1)	 	(50)(1)
	 

	 	1	 	1000(1)	 	(1000)(1)
	 Oxidizer—Gas(1)
	 	 	 	N.A.	 	N.A.
	 

 Pyrophoric
	 	`````	 	0	 	0
	 Unstable (Reactive)
	 	4	 	1/4(4)	 	(1/4)(4)
	 
	 	3	 	1(1)	 	(1)(1)
	 
	 	2	 	10(1)	 	(10)(1)
	 
	 	1	 	Not Limited	 	Not Limited
	 

 Water Reactive
	 	3	 	1(1)	 	(1)(1)
	 

	 	2	 	10(1)	 	(10)(1)
	 

	 	1	 	25(1)	 	(25)(1)
	 Biohazard Level 3 & 4 Agents
	 	None	 	None	 	None

 

 

	(1)
	Quantities
may be increased 100 percent in sprinklered buildings. When footnote 3 also applies, the increase for both footnotes may be applied.

	(2)
	Quantities
may be increased by 100 percent when stored in approved storage cabinets, gas cabinets or exhausted enclosures. When footnote 2 also
applies, the increase for both footnotes may be applied.

	(3)
	The
quantities permitted in a sprinklered building are not limited.

	(4)
	Permitted
in sprinklered buildings only. None is allowed in unsprinklered buildings. 

 

 7

 
 

 

				
	 Combustible Liquid—
	 	 
	 	 Class II—
	 	 Acetic Acid, Acetic Anhydride, Acrylic Acid, Benzenethiol, Formic Acid, Kerosene, Naphtha, Vinyl Toluene

	 	 Class III-A—
	 	Aniline, Benzyl Chloride, Chloroacetaldehyde, Cyclohexanone, Diazinon, Dimethyl Sulfate, Divinyl Benzene, Ethanolamine, Formalin, Nitrobenzene
	 	 Class III-B—
	 	Diethanolamine, Ethylene Glycol, Formamide, Glycerin, Malathion, Parathion, Resorcinol
	 Cryogenic Fluids—
	 	 Flammable (Carbon monoxide, Deuterium, Ethylene, Hydrogen, Methane)

Oxidizer (Fluorine, Nitric Oxide, Oxygen)

	 Explosives—
	 	 Black Powder, Dynamite, Nitrocellulose, Nitroglycerine

	 Flammable Solid—
	 	 Camphor, Cellulose Nitrate, Napthalene, Decaborane, Lithium Amide, Potassium

	 Flammable Gas—
	 	 Sulfide, Sulfur, Combustible Metals (Cesium, Magnesium and Zirconium) Acetylene, Arsine, Carbon Monoxide, Cyanogen, Diborane,
Ethane, Ethylene, Formaldehyde, Hydrogen, Hydrogen Sulfide, LP Gas, Methane, Phosphine, Vinyl Chloride

	 Flammable Liquid—
	 	 
	 	 Class I-A—
	 	 Acetaldehyde, n-Butane, Dimethylamine, Ethylamine, Ethyl Chloride, Ethylene Oxide

	 	 Class I-B—
	 	Ethyl Ether, Ethyl Mercaptan, Hydrogen Cyanide, Isobutane, Pentane, Vinyl Bromide, Acetone, Acetonitrile, Acrolein, Acrylonitrile, Benzene, tert-Butyl Alcohol, Carbon Disulfide, Cyclohexane, Diethylamine, Dioxane, Ethyl
Acetate, Ethyl Alcohol, Gasoline, Heptane, Hexane, Isopropyl Acetate, Isopropyl Alcohol, Methyl Alcohol, Octane, Propionitrile, Propanol, Pyridine, Tetrahydrofuran, Toluene, Triethylamine, Vinyl Acetate
	 	 Class I-C—
	 	sec-Butyl Alcohol, Chlorobenzene, Cumene, Ethylenediamine, Hydrazine, Isoamyl Acetate, Nonane, Styrene, Turpentine, o-Xylene
	 Organic Peroxide (Unclassified, Detonatable)—

	 Organic Peroxide—
	 	 
	 	 Class I—
	 	 Acetyl Cyclohexane Sulfonyl 60-65%, Fulfonyl Peroxide, Benzoyl Peroxide over 98%, t-butyl hydroperoxide 90%

	 	 Class II—
	 	Acetyl Peroxide 25%, Peroxyacetic Acid 43%
	 	 Class III—
	 	Benzoyl Peroxide 78%,
	 	 Class IV—
	 	Benzoyl Peroxide 70%,
	 	 Class V—
	 	Benzoyl Peroxide 35%, 1,1-di-t-butyl peroxy 3,5,5-trimethylcyclonehexane 40%
	 Oxidizer—
	 	 
	 	 Class 4—
	 	 Ammonium Perchlorate, Ammonium Permanganate, Tetranitromethane

	 	 Class 3—
	 	Ammonium Dichlorate, Calcium Hypochlorite, Potassium Bromate, Potassium Chlorate, Sodium Bromate, Sodium Chlorate
	 	 Class 2—
	 	Barium Bromate, Barium Chlorate, Calcium Perchlorate, Lithium Perchlorate, Magnesium Perchlorate, Sodium Permanganate
	 	 Class 1—
	 	Inorganic Nitrates, Inorganic Nitrites, Ammonium Persulfate, Lithium Peroxide, Manganese Dioxide, Zinc Peroxide
	 Oxidizer (Gas)—
	 	 Oxygen, Ozone, Oxides of Nitrogen Fluorine and Chlorine

 

 8

 
 

 

				
	 Pyrophoric—
	 	 Gases (Diborane, Phosphine, Silane)

	 
	 	Solids (Cesium, hafnium, Lithium, White or Yellow Phosphorus, Plutonium, Potassium, Sodium)

Liquids (Diethyl Aluminum Chloride, Diethyl Beryllium, Diethyl Phosphine)
	 Unstable (Reactive)—
	 	 
	 	 Class 4—
	 	 Acetyl Peroxide, Dibutyl Peroxide, Ethyl Nitrate, Picric Acid Trinitrobenzene, Peroxyacetic Acid

	 	 Class 3—
	 	Hydrogen Peroxide greater than 52%, Hydroxylamine, Nitromethane, Perchloric Acid
	 	 Class 2—
	 	Acrolein, Acrylic Acid, Hydrazine, Sodium Perchlorate, Styrene, Vinyl Acetate
	 	 Class 1—
	 	Acetic Acid, Hydrogen Peroxide 35°/0 to 52%, Paraldehyde, Tetrahydrofuran
	 Water Reactive—
	 	 
	 	 Class 3—
	 	 Bromine Pentafluoride, Isobutylaluminum, Triethylaluminum,

	 	 Class 2—
	 	Calcium Carbide, Calcium Metal, Lithium Hydride, Sodium Metal, Sodium Peroxide Trichlorosilane
	 	 Class 1—
	 	Acetic Anhydride, Sodium Hydroxide, Sulfur Monochloride, Titanium Tetrachloride

 

 9

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