Document:

EX-4.2

 

Exhibit 4.2

WARRANT

TO PURCHASE COMMON STOCK

OF BIODEL INC.

JULY 19, 2006

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE AND MAY NOT BE SOLD,
TRANSFERRED OR OTHERWISE DISPOSED OF EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION
STATEMENT UNDER SUCH ACT AND APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN
APPLICABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF SUCH ACT AND SUCH LAWS.

THE SALE, TRANSFER OR ENCUMBRANCE OF THE SECURITIES REPRESENTED HEREBY ARE SUBJECT
TO THE TERMS AND CONDITIONS OF A STOCKHOLDERS’ AGREEMENT, DATED AS OF JULY 19, 2006
BY AND AMONG BIODEL, INC. AND CERTAIN HOLDERS OF ITS OUTSTANDING CAPITAL STOCK, AS
SUCH AGREEMENT MAY BE AMENDED. COPIES OF SUCH AGREEMENT MAY BE OBTAINED AT NO COST
BY WRITTEN REQUEST MADE BY THE HOLDER OF RECORD HEREOF TO THE SECRETARY OF BIODEL
INC.

	 	 	 
	 

	 	Warrant to Purchase [                    ]
	 

	 	Shares (subject to adjustment)
	 

	 	of Common Stock

BIODEL INC.

COMMON STOCK PURCHASE WARRANT

Void after July 19, 2013

     BIODEL, INC. (the “Company”), a Delaware corporation, hereby certifies that for value
received, [                    ] (“Holder”), a Delaware limited partnership or its successors or assigns (the
“Holder”), is entitled to purchase, subject to the terms and conditions hereinafter set forth, an
aggregate of [                    ] fully paid and nonassessable shares of Common Stock (as hereinafter
defined) of the Company, at an exercise price of $3.94 per share, subject to adjustment as provided
herein (the “Purchase Price”), at any time or from time to time prior to 5:00 P.M., New York City
time, on July 19, 2013 (the “Expiration Date”).

 

 

     This Warrant is issued pursuant to the Securities Purchase Agreement (the “Purchase
Agreement”), dated as of the date hereof, among the Company and the investors party thereto, and is
subject to the terms thereof. Capitalized terms used herein and not otherwise defined shall have
the respective meanings assigned to such terms in the Purchase Agreement. The Holder is entitled
to the rights and is subject to the obligations contained in the Purchase Agreement, the
Stockholders’ Agreement and the Registration Rights Agreement relating to the shares of Common
Stock issuable upon exercise of this Warrant.

     1. Definitions. For the purposes of this Warrant, the following terms shall have the
meanings indicated:

          “Base Dilution Price” shall have the meaning ascribed to such term in Section 3(b).

          “Board” shall mean the Board of Directors of the Company.

          “Business Day” shall mean any day other than a Saturday, Sunday or other day on which
commercial banks in the City of New York are authorized or required by law or executive order to
close.

          “Closing Price” shall mean, with respect to each share of Common Stock for any day,
(a) the last reported sale price regular way or, in case no such sale takes place on such day, the
average of the closing bid and asked prices regular way, in either case as reported on the
principal national securities exchange on which the Common Stock is listed or admitted for trading
or (b) if the Common Stock is not listed or admitted for trading on any national securities
exchange, the last reported sale price or, in case no such sale takes place on such day, the
average of the highest reported bid and the lowest reported asked quotation for the Common Stock,
in either case as reported on the NASDAQ or a similar service if NASDAQ is no longer reporting such
information or (c) if the Closing Price is not reported as provided in clauses (a) or (b), Closing
Price shall mean the price determined in good faith by the Board.

          “Common Stock” means the common stock, par value $0.01per share, of the Company, and
any class of stock resulting from successive changes or reclassification of such Common Stock.

          “Company” has the meaning ascribed to such term in the first paragraph of this
Warrant.

          “Current Market Price” shall be determined in accordance with Subsection 3(e).

          “Dilution Price” shall mean, with respect to each share of Common Stock, $3.94 as
adjusted in accordance with the terms of Section 3, it being understood that this price is based on
the

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representation of the Company in the Purchase Agreement that there are [                    ] shares of
Common Stock outstanding on a fully diluted basis on the date hereof.

          “Election to Purchase Shares” shall have the meaning ascribed to such term in Section
2(a).

          “Exercise Date” has the meaning ascribed to such term in Subsection 2(d).

          “Expiration Date” has the meaning ascribed to such term in the first paragraph of this
Warrant.

          “Holder” has the meaning ascribed to such term in the first paragraph and Section 9 of
this Warrant.

          “Issued Warrant Shares” means any shares of Common Stock issued upon exercise of the
Warrant.

          “NASDAQ” shall mean the Automatic Quotation System of the National Association of
Securities Dealers, Inc.

          “Person” shall mean any individual, firm, corporation, limited liability company,
partnership, trust, incorporated or unincorporated association, joint venture, joint stock company,
government (or an agency or political subdivision thereof) or other entity of any kind, and shall
include any successor (by merger or otherwise) of such entity.

          “Purchase Agreement” has the meaning ascribed to such term in the second paragraph of
this Warrant.

          “Purchase Price” has the meaning ascribed to such term in the first paragraph of this
Warrant.

          “Qualified Subsequent Investment” shall mean the raising of equity capital by the
Company of at least $10,000,000.

          “Registration Rights Agreement” means the Registration Rights Agreement substantially
in the form attached to the Purchase Agreement as Exhibit C.

          “Securities” shall have the meaning ascribed to such term in Section 3(d)(i).

          “Stockholders’ Agreement” means the Stockholders’ Agreement substantially in the form
attached to the Purchase Agreement as Exhibit D.

          “Subject Securities” shall have the meaning ascribed to such term in Section
3(d)(iii).

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          “Successful Superiority Trial” shall mean completion of the ViajectTM 010JM trial currently
being conducted, in addition to the following:

     A. The results of such trial demonstrate that ViajectTM achieves better glucose
control than the FDA comparator, Humulin® when administered before a standardized
meal to patients with Type 1 diabetes.

     B. For the purposes of such trial, the Area Under the Curve (AUC) for blood
glucose in the first two hours after ingesting a standardized meal, with base-line
values subtracted, shall be measured in the same patients on separate days, after
administration of either Humulin® or ViajectTM at the same dose. A student’s
two-tailed “t” test, with the probability of an alpha error set at equal to or less
than 0.05 will be applied to the data.

     C. The standard set for such trial is such that if the AUC for blood glucose in
the first two hours after ingestion of a standardized meal of the patients treated
with ViajectTM is statistically significantly lower than those same patients treated
with the same dose of Humulin®, then better post-prandial glucose control will be
said to have been achieved by ViajectTM.

          “Warrant” shall mean this Warrant and any subsequent Warrant issued pursuant to the
terms of this Warrant.

          “Warrant Register” has the meaning ascribed to such term in Subsection 9(c).

     2. Exercise of Warrant.

          (a) Exercise. This Warrant may be exercised, in whole or in part, at any time or from
time to time during the period beginning on the date hereof and ending on the Expiration Date, by
surrendering to the Company at its principal office this Warrant, with the form of Election to
Purchase Shares (the “Election to Purchase Shares”) attached hereto as Exhibit A duly
executed by the Holder and accompanied by payment of the Purchase Price for the number of shares of
Common Stock specified in such form.

          (b) Delivery of Shares; Payment of Purchase Price. As soon as practicable after
surrender of this Warrant and receipt of payment, the Company shall promptly issue and deliver to
the Holder a certificate or certificates for the number of shares of Common Stock set forth in the
Election to Purchase Shares, in such name or names as may be designated by such Holder, along with
a check for the amount of cash to be paid in lieu of issuance of fractional shares, if any. Payment
of the Purchase Price may be made as follows (or by any combination of the following): (i) in
United States currency by cash, delivery of a certified check, bank draft or postal or express
money order payable to the order of the Company, or by wire transfer of

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immediately available funds
to the Company in accordance with wire transfer instructions furnished by the Company to the Holder
(ii) by surrender of a number of shares of Common Stock held by the Holder equal to the quotient
obtained by dividing (A) the aggregate Purchase Price payable with respect to the portion of this
Warrant then being exercised by (B) the Current Market Price per share of
Common Stock on the Exercise Date, or (iii) by cancellation of any portion of this Warrant
with respect to the number of shares of Common Stock equal to the quotient obtained by dividing (A)
the aggregate Purchase Price payable with respect to the portion of this Warrant then being
exercised by (B) the difference between (1) Current Market Price per share of Common Stock on the
Exercise Date, and (2) the Purchase Price per share of Common Stock.

          (c) Partial Exercise. If this Warrant is exercised for less than all of the shares of
Common Stock purchasable under this Warrant, the Company shall cancel this Warrant upon surrender
hereof and shall execute and deliver to the Holder a new Warrant of like tenor for the balance of
the shares of Common Stock purchasable hereunder.

          (d) When Exercise Effective. The exercise of this Warrant shall be deemed to have been
effective immediately prior to the close of business on the Business Day on which this Warrant is
surrendered to and the Purchase Price is received by the Company as provided in this Section 2 (the
“Exercise Date”) and the Person in whose name any certificate for shares of Common Stock shall be
issuable upon such exercise, as provided in Subsection 2(b), shall be deemed to be the record
holder of such shares of Common Stock for all purposes on the Exercise Date.

          (e) Issued Warrant Shares Fully Paid, Nonassessable. The Company shall take all
actions necessary to ensure that following exercise of this Warrant in accordance with the
provisions of this Section 2, the Issued Warrant Shares issued hereunder shall, without further
action by the Holder, be fully paid and nonassessable.

          (f) Continued Validity. A Holder of shares of Common Stock issued upon the exercise
of this Warrant, in whole or in part, shall continue to be entitled to all of the rights and
subject to all of the obligations set forth in Section 9.

     3. Adjustment of Purchase Price and Number of Shares. The Purchase Price, Dilution
Price and the number of shares of Common Stock issuable upon exercise of this Warrant shall be
adjusted from time to time in the following manner upon the occurrence of the following events:

          (a) Dividend, Subdivision, Combination or Reclassification of Common Stock. If the
Company shall, at any time or from time to time, (i) declare a dividend on the Common Stock payable
in shares of its capital stock (including Common Stock), (ii) subdivide the outstanding Common
Stock into a larger number of shares of Common Stock, (iii) combine the outstanding Common Stock
into a smaller number of shares of

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its Common Stock, or (iv) issue any shares of its capital stock
in a reclassification of the Common Stock (including any such reclassification in connection with a
consolidation or merger in which the Company is the continuing corporation), then in each
such case, the Dilution Price in effect at the time of the record date for such dividend or of the
effective date of such subdivision, combination or reclassification, and the number and kind of
shares of capital stock issuable on such date shall be proportionately adjusted so that the Holder
of any Warrant exercised after such date shall be entitled to receive, upon payment of the
same aggregate amount as would have been payable before such date, the aggregate number and
kind of shares of capital stock which, if such Warrant had been exercised immediately prior to such
date, such Holder would have owned upon such exercise and been entitled to receive by virtue of
such dividend, subdivision, combination or reclassification. Any such adjustment shall become
effective immediately on the payment date of such dividend or the effective date of such
subdivision, combination or reclassification. Such adjustment shall be made successively whenever
any event listed above shall occur. If a dividend is declared and such dividend is not paid, the
Dilution Price shall again be adjusted to be the Dilution Price in effect immediately prior to such
record date (giving effect to all adjustments that otherwise would be required to be made pursuant
to this Section 3 from and after such record date).

          (b) Issuance of Rights to Purchase Common Stock Below Dilution Price. If the Company
shall, at any time or from time to time after the date hereof, fix a record date for the issuance
of rights, options or warrants to all holders of Common Stock entitling them to subscribe for or
purchase Common Stock, or securities convertible into or exchangeable for Common Stock at a price
per share of Common Stock or having a conversion price per share of Common Stock if a security is
convertible into or exchangeable for Common Stock (determined in either such case by dividing (x)
the total consideration paid and/or payable to the Company upon exercise, conversion or exchange of
such rights, options, warrants or other securities convertible into or exchangeable for Common
Stock by (y) the total number of shares of Common Stock covered by such rights, options, warrants
or other securities convertible into or exchangeable for Common Stock) which is lower than the
Dilution Price, then the Dilution Price shall be reduced to the price per share of the Common Stock
to be so offered (or the initial conversion price of the convertible securities to be so offered)
as determined under clauses (x) and (y) above, provided, however, if either a
Successful Superiority Trial has been completed or the issuance of the securities contemplated in
this section is being effected at least six months after the completion of a Qualified Subsequent
Investment, then (I) the Dilution Price in effect immediately prior to the issuance of such
securities shall first be reduced to the price which is the greater of (A) the price per share of
such Common Stock (as determined pursuant to clauses (x) and (y)) and (B) the price computed by
dividing forty million by the number of shares of Common Stock outstanding immediately prior to the
issuance of the securities (after giving effect to the full exercise, conversion or exchange, as
applicable of such securities and all other securities of the Company outstanding) (the price so
determined under this clause (B), the “Base Dilution Price”), and (II) if the Dilution Price is
reduced pursuant to clause ((I)(B), the Dilution Price shall be further reduced so that it shall
equal the price determined by multiplying Base

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Dilution Price by a fraction the numerator of which
shall be the number of shares of Common Stock outstanding immediately prior to the issuance of the
securities contemplated in this section plus the number of shares of Common Stock which the
aggregate consideration received for the issuance of the securities would purchase at the Base
Dilution Price, and the denominator of which shall be the number of shares of Common Stock
outstanding immediately after the issuance of the securities (after giving effect to the full
exercise, conversion or exchange, as applicable, of such securities and all other securities of the
Company outstanding; provided, further, however, that such adjustment shall
be
made only if such adjustment results in an Dilution Price which is lower than the Dilution
Price in effect immediately prior to such record date. In case such price for subscription or
purchase may be paid in a consideration part or all of which shall be in a form other than cash,
the value of such consideration shall be determined in good faith by the Board. Any such adjustment
shall become effective immediately after the record date for such rights or warrants. Such
adjustment shall be made successively whenever such a record date is fixed. If such rights or
warrants are not issued, or expire or terminate without the exercise of such rights or warrants and
no securities are issued pursuant thereto, the Dilution Price shall be adjusted to the Dilution
Price that otherwise would be in effect but for the fact that such record date had been fixed.

          (c) Certain Distributions. If the Company shall, at any time or from time to time, fix
a record date for the distribution to all holders of Common Stock (including any such distribution
made in connection with a consolidation or merger in which the Company is the continuing
corporation) of evidences of indebtedness, assets or other property (other than regularly scheduled
cash dividends or cash distributions payable out of consolidated earnings or earned surplus or
dividends payable in capital stock for which adjustment is made under Subsection 3(a)) or
subscription rights, options or warrants (excluding those referred to in Subsection 3(b)), then the
number and kind of shares of capital stock or other property issuable on such date shall be
proportionately adjusted so that the Holder of any Warrant exercised after such date shall be
entitled to receive, upon payment of the same aggregate amount as would have been payable before
such date, the aggregate number and kind of shares of capital stock and other property which, if
such Warrant had been exercised immediately prior to such record date, such Holder would have owned
upon such exercise and been entitled to receive by virtue of such distribution. Any such
adjustment shall become effective immediately after the record date for such distribution. Such
adjustments shall be made successively whenever such a record date is fixed. In the event that such
distribution is not so made, the number of shares of Common Stock or other property which may be
received upon exercise of this Warrant shall be adjusted to the number in effect immediately prior
to such record date (giving effect to all adjustments that otherwise would be required to be made
pursuant to this Section 3 from and after such record date).

          (d) Issuance of Common Stock Below Dilution Price.

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               (i) If the Company shall, at any time and from time to time, after the date hereof, directly
or indirectly, sell or issue shares of Common Stock (regardless of whether originally issued or
from the Company’s treasury), or rights, options, warrants or convertible or exchangeable
securities containing the right to subscribe for or purchase shares of Common Stock) at a price per
share of Common Stock (determined, in the case of rights, options, warrants or convertible or
exchangeable securities (collectively, “Securities”), by dividing (x) the total consideration
received or receivable by the Company in consideration of the sale or issuance of such Securities,
plus the total consideration payable to the Company upon exercise or conversion or exchange
thereof, by (y) the total number of shares of Common Stock covered by such
Securities) which is lower than the Dilution Price in effect immediately prior to such sale or
issuance, then, subject to clause 3(d)(ii), the Dilution Price shall be reduced to the
consideration received (in the case of Securities, determined as provided herein) per share of
Common Stock with respect to such sale or issuance; provided, however, if either a
Successful Superiority Trial has been completed or the issuance of the securities contemplated in
this section is being effected at least six months after the completion of a Qualified Subsequent
Investment, then (I) the Dilution Price in effect immediately prior to the issuance of such
Securities shall first be reduced to the price which is the greater of (A) the price per share of
such Common Stock (as determined pursuant to clauses (x) and (y)) and (B) the Base Dilution Price
and (II) if the Dilution Price is reduced pursuant to clause ((I)(B), the Dilution Price shall be
further reduced so that it shall equal the price determined by multiplying Base Dilution Price by a
fraction the numerator of which shall be the number of shares of Common Stock outstanding
immediately prior to the issuance of the Securities contemplated in this section plus the number of
shares of Common Stock which the aggregate consideration received for the issuance of the
Securities would purchase at the Base Dilution Price, and the denominator of which shall be the
number of shares of Common Stock outstanding immediately after the issuance of the Securities
(after giving effect to the full exercise, conversion or exchange, as applicable, of such
securities and all other securities of the Company outstanding; provided, further, however that
such adjustment shall be made only if such adjustment results in an Dilution Price which is lower
than the Dilution Price in effect immediately prior to taking such action. Such adjustment shall
be made successively whenever such sale or issuance is made. For the purposes of such adjustments,
the shares of Common Stock which the holder of any such Securities shall be entitled to subscribe
for or purchase shall be deemed to be issued and outstanding as of the date of such sale or
issuance of such Securities and the consideration “received” by the Company therefor shall be
deemed to be the consideration actually received or receivable by the Company (plus any
underwriting discounts or commissions in connection therewith) for such Securities, plus the
consideration stated in such Securities to be payable to the Company for the shares of Common Stock
covered thereby. If the Company shall sell or issue shares of Common Stock for a consideration
consisting, in whole or in part, of property other than cash or its equivalent, then in determining
the “price per share of Common Stock” and the “consideration” received or receivable by or payable
to the Company for purposes of the first sentence and the immediately preceding sentence of this
Subsection 3(d)(i), the fair value of such property shall be determined in good

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faith by the Board.
Except as provided below, the determination of whether any adjustment is required under this
Subsection 3(d)(i) by reason of the sale or issuance of Securities and the amount of such
adjustment, if any, shall be made only at the time of such issuance or sale and not at the
subsequent time of issuance of shares of Common Stock upon the exercise, conversion or exchange of
such Securities.

               (ii) No adjustment shall be made to the Dilution Price pursuant to clause 3(d)(i) in
connection with the issuance of (A) shares issued in any of the transactions described in
Subsections 3(a), (b) and (c) hereof; (B) shares issued upon exercise of this Warrant; (C) shares
issued upon conversion of the Series A Convertible Preferred Stock of the Company, or the Series B
Convertible Preferred Stock (the “Convertible Preferred Stock”); (D) options to
purchase an aggregate of 1,248,500 additional shares of Common Stock pursuant to any stock
option or stock plan or arrangement of the Company in effect on the date hereof, as amended or
supplemented after the date hereof, outstanding on the date of this Warrant hereafter granted at an
exercise price of not less than the Current Market Price of Common Stock at the time of grant.

               (iii) Notwithstanding any provision in this Section 3 to the contrary and without limitation
to any other provision contained in this Section 3, in the event any securities of the Company
(other than this Warrant or the Convertible Preferred Stock, including, without limitation, those
securities set forth as exceptions in Subsection 3(d)(ii) (for purposes of this Subsection,
collectively, the “Subject Securities”) are amended or otherwise modified by operation of its terms
or otherwise (including, without limitation, by operation of such Subject Securities’ anti-dilution
provisions, other than those anti-dilution provisions contained within the Subject Securities that
are substantially similar to the provisions of Section 3(a) hereof) in any manner whatsoever that
results in (i) the reduction of the exercise, conversion or exchange price of such Subject
Securities payable upon the exercise for, or conversion or exchange into, Common Stock or other
securities exercisable for, or convertible or exchangeable into, Common Stock and/or (ii) such
Subject Securities becoming exercisable for, or convertible or exchangeable into (A) more shares or
dollar amount of such Subject Securities which are, in turn exercisable for, or convertible or
exchangeable into, Common Stock, or (B) more shares of Common Stock, then such amendment or
modification shall be treated for purposes of Section 3 as if the Subject Securities which have
been amended or modified have been terminated and new securities have been issued with the amended
or modified terms. The Company shall make all necessary adjustments (including successive
adjustments if required) to the Dilution Price in accordance with Section 3. Upon the expiration
or termination of the right to exercise, convert or exchange any Securities without any shares of
Common Stock having been issued pursuant to such right, any adjustment to the Dilution Price which
was made upon the issuance of such Securities shall be adjusted to the Dilution Price that
otherwise would be in effect but for the fact of the issuance of such Securities.

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          (e) Determination of Current Market Price. For the purpose of any computation under
Subsections (b), (c) or (d) of this Section 3 or any other provision of this Warrant, the Current
Market Price per share of Common Stock on any date shall be deemed to be the average of the daily
Closing Prices per share of Common Stock for the 5 consecutive trading days commencing 7 trading
days before such date. If on any such date the shares of Common Stock are not listed or admitted
for trading on any national securities exchange or quoted by NASDAQ or a similar service, then the
Company, on the one hand, and the Holder, on the other hand, shall each promptly appoint as an
appraiser an individual who shall be a member of a nationally recognized investment banking firm.
Each appraiser shall be instructed to, within 30 days of appointment, determine the Current Market
Price per share of Common Stock which shall be deemed to be equal to the fair market value per
share of Common Stock as of such date. If the two appraisers are unable to agree on the Current
Market Price per share of Common Stock within such 30 day period, then the two appraisers, within
10 days after the end of such 30 day period shall jointly
select a third appraiser. The third appraiser shall, within 30 days of its appointment,
determine, in good faith, the Current Market Price per share of Common Stock and such determination
shall be controlling. If any party fails to appoint an appraiser or if one of the two initial
appraisers fails after appointment to submit its appraisal within the required period, the
appraisal submitted by the remaining appraiser shall be controlling. The cost of the foregoing
appraisals shall be shared one-half by the Company and one-half by the Holder, provided,
however, in the event a third appraiser is utilized and one of the two initial appraisals
(but not the other initial appraisal) is greater than or less than the appraisal by such third
appraiser by 10% or more, then the cost of all of the foregoing appraisals shall be borne by the
party who appointed the appraiser who made such initial appraisal.

          (f) Adjustment to Purchase Price. Upon each adjustment to the Dilution Price pursuant
to Section 3, the Purchase Price shall be adjusted by multiplying the Purchase Price in effect
immediately prior to such adjustment by a fraction, the numerator of which shall be the Dilution
Price as so adjusted and the denominator of which shall be the Dilution Price in effect immediately
prior to such adjustment.

          (g) Adjustment of Number of Shares Issuable Upon Exercise. Upon each adjustment of the
Dilution Price and the Purchase Price as a result of the calculations made in Subsections 3(a), (b)
or (d), this Warrant shall thereafter evidence the right to receive, at the adjusted Purchase
Price, that number of shares of Common Stock (calculated to the nearest one-hundredth) obtained by
dividing (x) the product of the aggregate number of shares of Common Stock covered by this Warrant
immediately prior to such adjustment and the Purchase Price in effect immediately prior to such
adjustment of the Purchase Price by (y) the Purchase Price in effect immediately after such
adjustment of the Purchase Price.

          (h) De Minimis Adjustments. No adjustment shall be made under this Section 3 if the
amount of such adjustment would result in a change in the Dilution Price per share of less

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than
$0.05, but in such case
any adjustment that would otherwise be required to be made shall be carried
forward and shall be made at the time of and together with the next subsequent adjustment, which
together with any adjustment so carried forward, would result in a change in the Dilution Price of
$0.05 or more per share. Notwithstanding the provisions of the first sentence of this Subsection
3(h), any adjustment postponed pursuant to this Subsection 3(h) shall be made no later than the
earlier of (i) three years from the date of the transaction that would, but for the provisions of
the first sentence of this Section 3(h), have required such adjustment, (ii) an Exercise Date or
(iii) the Expiration Date.

          (i) Adjustments to Other Shares. In the event that at any time, as a result of an
adjustment made pursuant to Subsection 3(a), the Holder shall become entitled to receive, upon
exercise of this Warrant, any shares of capital stock or other securities of the Company other than
shares of Common Stock, the number of such other shares or securities so receivable upon exercise
of this Warrant shall be subject to adjustment from time to time in a manner and on terms as nearly
equivalent as practicable to the provisions with respect to the shares of Common Stock
contained in Subsections 3(a), (b), (c) and (d), inclusive, and the provisions of Sections 2,
5, 6 and 7 with respect to the shares of Common Stock shall apply on like terms to any such other
shares or securities.

          (j) Reorganization, Reclassification, Merger and Sale of Assets. If there occurs any
capital reorganization or any reclassification of the Common Stock of the Company, the
consolidation or merger of the Company with or into another Person (other than a merger or
consolidation of the Company in which the Company is the continuing corporation and which does not
result in any reclassification or change of outstanding shares of its Common Stock) or the sale or
conveyance of all or substantially all of the assets of the Company to another Person, then
the Holder will thereafter be entitled to receive, upon the exercise of this Warrant in accordance
with the terms hereof, the same kind and amounts of securities (including shares of stock) or other
assets, or both, which were issuable or distributable to the holders of outstanding Common Stock of
the Company upon such reorganization, reclassification, consolidation, merger, sale or conveyance,
in respect of that number of shares of Common Stock then deliverable upon the exercise of this
Warrant if this Warrant had been exercised immediately prior to such reorganization,
reclassification, consolidation, merger, sale or conveyance; and, in any such case, appropriate
adjustments (as determined in good faith by the Board of Directors of the Company) shall be made to
assure that the provisions hereof (including, without limitation, provisions with respect to
changes in, and other adjustments of, the Purchase Price and the Dilution Price) shall thereafter
be applicable, as nearly as reasonably may be practicable, in relation to any securities or other
assets thereafter deliverable upon exercise of this Warrant.

     4. Certificate as to Adjustments. Whenever the Purchase Price, the Dilution Price or
the number of shares of Common Stock issuable, or the securities or other property deliverable,
upon the exercise of this Warrant shall be adjusted pursuant to the provisions hereof, the Company

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shall promptly give written notice thereof to the Holder, in accordance with Section 13, in the
form of a certificate signed by the Chairman of the Board, President or one of the Vice Presidents
of the Company, and by the Chief Financial Officer, Treasurer or one of the Assistant Treasurers of
the Company, stating the adjusted Purchase Price and Dilution Price, the number of shares of Common
Stock issuable, or the securities or other property deliverable, upon exercise of the Warrant and
setting forth in reasonable detail the method of calculation and the facts requiring such
adjustment and upon which such calculation is based. Each adjustment shall remain in effect until a
subsequent adjustment is required.

     5. Fractional Shares. Notwithstanding an adjustment pursuant to Section 3(g) in the
number of shares of Common Stock covered by this Warrant or any other provision of this Warrant,
the Company shall not be required to issue fractions of shares upon exercise of this Warrant or to
distribute certificates which evidence fractional shares. In lieu of fractional shares, the Company
may make payment to the Holder, at the time of exercise of this Warrant as herein provided, of an
amount in cash equal to such fraction multiplied by the greater of the Current Market Price of a
share of Common Stock on the Exercise Date and the Dilution Price.

     6. Notice of Proposed Actions. In case the Company shall propose at any time or from
time to time (a) to declare or pay any dividend payable in stock of any class to the holders of
Common Stock or to make any other distribution to the holders of Common Stock (other than a
regularly scheduled cash dividend), (b) to offer to the holders of Common Stock rights or warrants
to subscribe for or to purchase any additional shares of Common Stock or shares of stock of any
class or any other securities, rights, warrants or options, (c) to effect any reclassification of
its Common Stock, (d) to effect any consolidation, merger or sale, transfer or other disposition of
all or substantially all of the property, assets or business of the Company which would, if
consummated, adjust the Purchase Price, the Dilution Price or the securities issuable upon exercise
of the Warrants, (e) to effect the liquidation, dissolution or winding up of the Company, or (f) to
take any other action that would require a vote of the Company’s stockholders, then, in each such
case, the Company shall give to the Holder, in accordance with Section 13, a written notice of such
proposed action, which shall specify (i) the record date for the purposes of such stock dividend,
distribution of rights or warrants or vote of the stockholders of the Company, or if a record is
not to be taken, the date as of which the holders of shares of Common Stock of record to be
entitled to such dividend, distribution of rights or warrants, or vote is to be determined, or (ii)
the date on which such reclassification, consolidation, merger, sale, transfer, disposition,
liquidation, dissolution or winding up is expected to become effective, and such notice shall be so
given as promptly as possible but in any event at least ten (10) Business Days prior to the
applicable record, determination or effective date specified in such notice.

     7. No Dilution or Impairment. The Company will not, by amendment of its Certificate of
Incorporation or through any reorganization, transfer of assets, consolidation, merger,

12

 

dissolution, issue or sale of securities or any other action, avoid or seek to avoid the observance
or performance of any of the terms of this Warrant, but will at all times in good faith assist in
the carrying out of all such terms and in the taking of all such action as may be necessary or
appropriate in order to protect the rights of the Holder of this Warrant against dilution (other
than the dilutive events covered in Section 3 herein) or other impairment. Without limiting the
generality of the foregoing, the Company (a) will not increase the par value of any shares of stock
receivable on the exercise of this Warrant above the amount payable therefor on such exercise, (b)
will at all times reserve and keep available the maximum number of its authorized shares of Common
Stock, free from all preemptive rights therein, which will be sufficient to permit the full
exercise of this Warrant, and (c) will take all such action as may be necessary or appropriate in
order that all shares of Common Stock as may be issued pursuant to the exercise of this Warrant
will, upon issuance, be duly and validly issued, fully paid and nonassessable, and free from all
taxes, liens and charges as to the holders of the Warrant exercised with respect to the issue
thereof.

     8. Replacement of Warrants. On receipt by the Company of an affidavit of an authorized
representative of the Holder stating the circumstances of the loss, theft, destruction or
mutilation of this Warrant (and in the case of any such mutilation, on surrender and cancellation
of such
Warrant), the Company at its expense will promptly execute and deliver, in lieu thereof, a new
Warrant of like tenor which shall be exercisable for a like number of shares of Common Stock. If
required by the Company, such Holder must provide an indemnity bond or other indemnity sufficient
in the judgment of the Company to protect the Company from any loss which it may suffer if a lost,
stolen or destroyed Warrant is replaced.

     9. Restrictions on Transfer.

          (a) Subject to the provisions of this Section 9, this Warrant may be transferred or assigned,
in whole or in part, by the Holder at any time, and from time to time. The term “Holder” as used
herein shall also include any transferee of this Warrant whose name has been recorded by the
Company in the Warrant Register (as hereinafter defined). Each transferee of the Warrant or the
Common Stock issuable upon the exercise of the Warrant acknowledges that the Warrant or the Common
Stock issuable upon the exercise of the Warrant has not been registered under the Securities Act
and may be transferred only pursuant to an effective registration under the Securities Act or
pursuant to an applicable exemption from the registration requirements of the Securities Act.

          (b) With respect to a transfer that should occur prior to the time that the Warrant or the
Common Stock issuable upon the exercise thereof is registered under the Securities Act, such Holder
shall request an opinion of counsel (which shall be rendered by counsel reasonably acceptable to
the Company) that the proposed transfer may be effected without registration or qualification under
any Federal or state securities or blue sky law. Counsel shall, as promptly as practicable, notify
the Company and the Holder of such opinion and of the terms and conditions,

13

 

if any, to be observed
in such transfer, whereupon the Holder shall be entitled to transfer this Warrant or such shares of
Common Stock (or portion thereof), subject to any other provisions and limitations of this Warrant.
In the event this Warrant shall be exercised as an incident to such transfer, such exercise shall
relate back and for all purposes of this Warrant be deemed to have occurred as of the date of such
notice regardless of delays incurred by reason of the provisions of this Section 9 which may result
in the actual exercise on any later date.

          (c) The Company shall maintain a register (the “Warrant Register”) in its principal office for
the purpose of registering the Warrant and any transfer thereof, which register shall reflect and
identify, at all times, the ownership of any interest in the Warrant. Upon the issuance of this
Warrant, the Company shall record the name of the initial purchaser of this Warrant in the Warrant
Register as the first Holder. Upon surrender for registration of transfer or exchange of this
Warrant together with a properly executed Form of Assignment attached hereto as Exhibit B
at the principal office of the Company, the Company shall, at its expense, execute and deliver one
or more new Warrants of like tenor which shall be exercisable for a like aggregate number of shares
of Common Stock, registered in the name of the Holder or a transferee or transferees.

          (d) Notwithstanding any provision of this Warrant to the contrary, this Warrant and any shares
of Common Stock issued upon the exercise thereof are subject to the terms and
conditions of the Stockholders Agreement, and may only be transferred in accordance with the
provisions thereof. Each certificate representing Issued Warrant Shares shall bear the following
legend (provided that the name of the Company referenced therein shall refer to the then current
name of the Company, if such name is different) until such time as the Issued Warrant Shares
represented thereby are no longer subject to the provisions of the Stockholders Agreement:

THE SALE, TRANSFER OR ENCUMBRANCE OF THE SECURITIES REPRESENTED BY THIS CERTIFICATE
ARE SUBJECT TO THE TERMS AND CONDITIONS OF A STOCKHOLDERS’ AGREEMENT, DATED AS OF
JULY 19, 2006 BY AND AMONG BIODEL INC. AND CERTAIN HOLDERS OF ITS OUTSTANDING
CAPITAL STOCK, AS SUCH AGREEMENT MAY BE AMENDED. COPIES OF SUCH AGREEMENT MAY BE
OBTAINED AT NO COST BY WRITTEN REQUEST MADE BY THE HOLDER OF RECORD OF THIS
CERTIFICATE TO THE SECRETARY OF BIODEL INC.”

     10. No Rights or Liability as a Stockholder. This Warrant does not entitle the Holder
hereof to any voting rights or other rights as a stockholder of the Company. No provisions hereof,
in the absence of affirmative action by the Holder hereof to purchase Common Stock, and no
enumeration herein of the rights or privileges of the Holder shall give rise to any liability of
such Holder as a stockholder of the Company.

14

 

     11. Charges, Taxes and Expenses. Issuance of certificates for shares of Common Stock
upon the exercise of this Warrant shall be made without charge to the Holder hereof for any issue
or transfer tax, or other incidental expense, in respect of the issuance or delivery of such
certificates or the securities represented thereby, all of which taxes and expenses shall be paid
by the Company.

     12. Amendment or Waiver. Subject to the terms of the Section 7.5 of the Purchase
Agreement, this Warrant and any term hereof may be amended, waived, discharged or terminated only
by and with the written consent of the Company and the Holder.

     13. Notices. Any notice or other communication (or delivery) required or permitted
hereunder shall be made in writing and shall be by registered mail, return receipt requested,
telecopier, courier service or personal delivery to the Company at its principal office as
specified in Section 7.3 of the Purchase Agreement and to the Holder at its address as it appears
in the Warrant Register. All such notices and communications (and deliveries) shall be deemed to
have been duly given: when delivered by hand, if personally delivered; when delivered by courier,
if delivered by commercial overnight courier service; five Business Days after being deposited in
the mail, postage prepaid, if mailed; and when receipt is acknowledged, if telecopied.

     14. Certain Remedies. The Holder shall be entitled to an injunction or injunctions to
prevent breaches of the provisions of this Warrant and to enforce specifically the terms and
provisions of this Warrant in any court of the United States or any state thereof having
jurisdiction, this being in addition to any other remedy to which such Holder may be entitled
at law or in equity.

     15. Governing Law. THIS AGREEMENT SHALL BE GOVERNED BY, CONSTRUED IN ACCORDANCE WITH,
AND ENFORCED UNDER, THE LAWS OF THE STATE OF NEW YORK APPLICABLE TO AGREEMENTS OR INSTRUMENTS
ENTERED INTO AND PERFORMED ENTIRELY WITHIN SUCH STATE.

     16. Headings. The headings in this Warrant are for convenience of reference only and
shall not limit or otherwise affect the meaning hereof.

15

 

	 	 	 	 	 	 	 
	 	 	BIODEL INC.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Name:	 	 
	 

	 	 	 	Title:	 	 

 

 

	 	 	 	 	 
	 

	 	Exhibit A to Common
	 	 
	 

	 	Stock Purchase Warrant	 	 

FORM OF

ELECTION TO PURCHASE SHARES

     The
undersigned hereby irrevocably elects to exercise the Warrant to purchase                      shares of
Common Stock, par value $0.01per share (“Common Stock”), of Biodel Inc. (the “Company”) and hereby
[makes payment of $                     therefor] [or] [makes payment therefore by surrendering pursuant to
Section 2(b)(iii)
                     shares of Common Stock of the Company] [or] [makes payment therefor by
cancellation pursuant to Section 2(b)(iv) of a portion of the Warrant with respect to                     
shares of Common Stock]. The undersigned hereby requests that certificates for such shares be
issued and delivered as follows:

	 	 	 
	ISSUE TO:
	 	 
	 

	(NAME)

	 
	 	 
	 
	(ADDRESS, INCLUDING ZIP CODE)

	 
	 	 
	 
	(SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER)

	 
	 	 
	DELIVER TO:
	 	 
	 

	 	 
	(NAME)

	 
	 	 
	 
	(ADDRESS, INCLUDING ZIP CODE)

          If the number of shares of Common Stock purchased hereby is less than the number of shares of
Common Stock covered by the Warrant, the undersigned requests that a new Warrant representing the
number of shares of Common Stock not purchased be issued and delivered as follows:

	 	 	 
	ISSUE TO:
	 	 
	 

	(NAME OF HOLDER)

	 
	 	 
	 
	(ADDRESS, INCLUDING ZIP CODE)

	 
	 	 
	DELIVER TO:
	 	 
	 

	 	 
	(NAME OF HOLDER)

	 
	 	 
	 
	(ADDRESS, INCLUDING ZIP CODE)

	 	 	 	 	 	 	 	 	 	 	 
	Dated:	 	 	 	 	 	[NAME OF HOLDER]	 	 
	 

	 	 

	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	By:	 	 	 	 
	 

	 	 	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	 	 	Name:	 	 
	 

	 	 	 	 	 	 	 	Title:	 	 

 

			
	1	 	Name of Holder must conform in all respects to name of Holder as specified on the face
of the Warrant.

17

 

	 	 	 	 	 
	 

	 	Exhibit B to Common
	 	 
	 

	 	Stock Purchase Warrant	 	 

FORM OF ASSIGNMENT

          FOR VALUE RECEIVED, the undersigned hereby sells, assigns, and transfers unto the Assignee
named below all of the rights of the undersigned to purchase Common Stock, par value $0.01 per
share (“Common Stock”), of BIODEL INC. represented by the Warrant, with respect to the number of
shares of Common Stock set forth below:

Name of Assignee       Address       No. of Shares

and does hereby irrevocably constitute and appoint                                                              Attorney to make
such transfer on the books of BIODEL, INC. maintained for that purpose, with full power of
substitution in the premises.

	 	 	 	 	 	 	 	 	 	 	 
	Dated:	 	 	 	 	 	[NAME OF HOLDERSUP1
]	 	 
	 

	 	 

	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	By:	 	 	 	 
	 

	 	 	 	 	 	 	 	 	 	 
	 

	 	 	 	 	 	 	 	Name:	 	 
	 

	 	 	 	 	 	 	 	Title:	 	 

 

			
	1	 	Name of Holder must conform in all respects to name of Holder as specified on the face of the
Warrant.

18EX-4.3

 

Exhibit 4.3

WARRANT

TO PURCHASE COMMON STOCK

OF BIODEL INC.

JULY 19, 2006

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED, OR THE SECURITIES LAWS OF ANY STATE AND MAY NOT BE SOLD,
TRANSFERRED OR OTHERWISE DISPOSED OF EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION
STATEMENT UNDER SUCH ACT AND APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN
APPLICABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF SUCH ACT AND SUCH LAWS.

	 	 	 
	 

	 	Warrant to Purchase [                    ]
	 

	 	Shares (subject to adjustment)
	 

	 	of Common Stock

BIODEL INC.

COMMON STOCK PURCHASE WARRANT

Void after July 19, 2013

     BIODEL, INC. (the “Company”), a Delaware corporation, hereby certifies that for value
received, [                                        ] (“Holder”), or [its] [his/her] successors or assigns (the “Holder”), is
entitled to purchase, subject to the terms and conditions hereinafter set forth, an aggregate of
[                    ] fully paid and nonassessable shares of Common Stock (as hereinafter defined) of the Company,
at an exercise price of $3.94 per share, subject to adjustment as provided herein (the “Purchase
Price”), at any time or from time to time prior to 5:00 P.M., New York City time, on July 19, 2013
(the “Expiration Date”).

     This Warrant is issued pursuant to the Subscription Rights and Investment Representation
Agreements between the Company, on the one hand, and each holder of the Company’s Units, consisting
of a 7% Note and a seven-year warrant (the “Units”), issued by the Company pursuant to that
certain Private Placement Memorandum dated February 2006 and delivered to the holders of such Units
by the Company in connection with the offer for sale and sale of the Units. The Holder is

 

 

entitled to the rights and is subject to the obligations contained in the Registration Rights Agreement
relating to the shares of Common Stock issuable upon exercise of this Warrant.

     1. Definitions. For the purposes of this Warrant, the following terms shall have the
meanings indicated:

          “Base Dilution Price” shall have the meaning ascribed to such term in Section 3(b).

          “Board” shall mean the Board of Directors of the Company.

          “Business Day” shall mean any day other than a Saturday, Sunday or other day on which
commercial banks in the City of New York are authorized or required by law or executive order to
close.

          “Closing Price” shall mean, with respect to each share of Common Stock for any day,
(a) the last reported sale price regular way or, in case no such sale takes place on such day, the
average of the closing bid and asked prices regular way, in either case as reported on the
principal national securities exchange on which the Common Stock is listed or admitted for trading
or (b) if the Common Stock is not listed or admitted for trading on any national securities
exchange, the last reported sale price or, in case no such sale takes place on such day, the
average of the highest reported bid and the lowest reported asked quotation for the Common Stock,
in either case as reported on the NASDAQ or a similar service if NASDAQ is no longer reporting such
information or (c) if the Closing Price is not reported as provided in clauses (a) or (b), Closing
Price shall mean the price determined in good faith by the Board.

          “Common Stock” means the common stock, par value $0.01 per share, of the Company, and
any class of stock resulting from successive changes or reclassification of such Common Stock.

          “Company” has the meaning ascribed to such term in the first paragraph of this
Warrant.

          “Current Market Price” shall be determined in accordance with Subsection 3(e).

          “Dilution Price” shall mean, with respect to each share of Common Stock, $3.94 as
adjusted in accordance with the terms of Section 3, it being understood that this price is based on
the representation of the Company in the Purchase Agreement that there are 22,784,379 shares of
Common Stock outstanding on a fully diluted basis on the date hereof.

          “Election to Purchase Shares” shall have the meaning ascribed to such term in Section
2(a).

          “Exercise Date” has the meaning ascribed to such term in Subsection 2(d).

2

 

          “Expiration Date” has the meaning ascribed to such term in the first paragraph of this
Warrant.

          “Holder” has the meaning ascribed to such term in the first paragraph and Section 9 of
this Warrant.

          “Issued Warrant Shares” means any shares of Common Stock issued upon exercise of the
Warrant.

          “NASDAQ” shall mean the Automatic Quotation System of the National Association of
Securities Dealers, Inc.

          “Person” shall mean any individual, firm, corporation, limited liability company,
partnership, trust, incorporated or unincorporated association, joint venture, joint stock company,
government (or an agency or political subdivision thereof) or other entity of any kind, and shall
include any successor (by merger or otherwise) of such entity.

          “Purchase Agreement” has the meaning ascribed to such term in the second paragraph of
this Warrant.

          “Purchase Price” has the meaning ascribed to such term in the first paragraph of this
Warrant.

          “Qualified Subsequent Investment” shall mean the raising of equity capital by the
Company of at least $10,000,000.

          “Registration
Rights Agreement” means the Amended and Restated
Registration Rights Agreement between the Company, the Holder and
each of the other parties thereto.

          “Securities” shall have the meaning ascribed to such term in Section 3(d)(i).

          “Subject Securities” shall have the meaning ascribed to such term in Section
3(d)(iii).

          “Successful Superiority Trial” shall mean completion of the ViajectTM 010JM trial
currently being conducted, in addition to the following:

     A. The results of such trial demonstrate that ViajectTM achieves better glucose
control than the FDA comparator, Humulin® when administered before a standardized
meal to patients with Type 1 diabetes.

     B. For the purposes of such trial, the Area Under the Curve (AUC) for blood
glucose in the first two hours after ingesting a standardized meal, with base-line
values subtracted, shall be measured in the same patients on separate days, after
administration of either Humulin® or ViajectTM at the same dose. A

3

 

student’s
two-tailed “t” test, with the probability of an alpha error set at equal to or less
than 0.05 will be applied to the data.

     C. The standard set for such trial is such that if the AUC for blood glucose in
the first two hours after ingestion of a standardized meal of the patients treated
with ViajectTM is statistically significantly lower than those same patients treated
with the same dose of Humulin®, then better post-prandial glucose control will be
said to have been achieved by ViajectTM.

          “Warrant” shall mean this Warrant and any subsequent Warrant issued pursuant to the
terms of this Warrant.

          “Warrant Register” has the meaning ascribed to such term in Subsection 9(c).

     2. Exercise of Warrant.

          (a) Exercise. This Warrant may be exercised, in whole or in part, at any time or from
time to time during the period beginning on the date hereof and ending on the Expiration Date, by
surrendering to the Company at its principal office this Warrant, with the form of Election to
Purchase Shares (the “Election to Purchase Shares”) attached hereto as Exhibit A duly
executed by the Holder and accompanied by payment of the Purchase Price for the number of shares of
Common Stock specified in such form.

          (b) Delivery of Shares; Payment of Purchase Price. As soon as practicable after
surrender of this Warrant and receipt of payment, the Company shall promptly issue and deliver to
the Holder a certificate or certificates for the number of shares of Common Stock set forth in the
Election to Purchase Shares, in such name or names as may be designated by such Holder, along with
a check for the amount of cash to be paid in lieu of issuance of fractional shares, if any. Payment
of the Purchase Price may be made as follows (or by any combination of the following): (i) in
United States currency by cash, delivery of a certified check, bank draft or postal or express
money order payable to the order of the Company, or by wire transfer of immediately available funds
to the Company in accordance with wire transfer instructions furnished by the Company to the Holder
(ii) by surrender of a number of shares of Common Stock held by the Holder equal to the quotient
obtained by dividing (A) the aggregate Purchase Price payable with respect to the portion of this
Warrant then being exercised by (B) the Current Market Price per share of Common Stock on the
Exercise Date, or (iii) by cancellation of any portion of this Warrant with respect to the number
of shares of Common Stock equal to the quotient obtained by dividing (A) the aggregate Purchase
Price payable with respect to the portion of this Warrant then being exercised by (B) the
difference between (1) Current Market Price per share of Common Stock on the Exercise Date, and (2)
the Purchase Price per share of Common Stock.

          (c) Partial Exercise. If this Warrant is exercised for less than all of the shares of
Common Stock purchasable under this Warrant, the Company shall cancel this Warrant upon

4

 

surrender
hereof and shall execute and deliver to the Holder a new Warrant of like tenor for the balance of
the shares of Common Stock purchasable hereunder.

          (d) When Exercise Effective. The exercise of this Warrant shall be deemed to have been
effective immediately prior to the close of business on the Business Day on which this Warrant is
surrendered to and the Purchase Price is received by the Company as provided in this Section 2 (the
“Exercise Date”) and the Person in whose name any certificate for shares of Common Stock shall be
issuable upon such exercise, as provided in Subsection 2(b), shall be deemed to be the record
holder of such shares of Common Stock for all purposes on the Exercise Date.

          (e) Issued Warrant Shares Fully Paid, Nonassessable. The Company shall take all
actions necessary to ensure that following exercise of this Warrant in accordance with the
provisions of this Section 2, the Issued Warrant Shares issued hereunder shall, without
further action by the Holder, be fully paid and nonassessable.

          (f) Continued Validity. A Holder of shares of Common Stock issued upon the exercise
of this Warrant, in whole or in part, shall continue to be entitled to all of the rights and
subject to all of the obligations set forth in Section 9.

     3. Adjustment of Purchase Price and Number of Shares. The Purchase Price, Dilution
Price and the number of shares of Common Stock issuable upon exercise of this Warrant shall be
adjusted from time to time in the following manner upon the occurrence of the following events:

          (a) Dividend, Subdivision, Combination or Reclassification of Common Stock. If the
Company shall, at any time or from time to time, (i) declare a dividend on the Common Stock payable
in shares of its capital stock (including Common Stock), (ii) subdivide the outstanding Common
Stock into a larger number of shares of Common Stock, (iii) combine the outstanding Common Stock
into a smaller number of shares of its Common Stock, or (iv) issue any shares of its capital stock
in a reclassification of the Common Stock (including any such reclassification in connection with a
consolidation or merger in which the Company is the continuing corporation), then in each
such case, the Dilution Price in effect at the time of the record date for such dividend or of the
effective date of such subdivision, combination or reclassification, and the number and kind of
shares of capital stock issuable on such date shall be proportionately adjusted so that the Holder
of any Warrant exercised after such date shall be entitled to receive, upon payment of the same
aggregate amount as would have been payable before such date, the aggregate number and kind of
shares of capital stock which, if such Warrant had been exercised immediately prior to such date,
such Holder would have owned upon such exercise and been entitled to receive by virtue of such
dividend, subdivision, combination or reclassification. Any such adjustment shall become effective
immediately on the payment date of such dividend or the effective date of such subdivision,
combination or reclassification. Such adjustment shall be made successively whenever any event
listed above shall occur. If a dividend is declared and such dividend is not paid, the Dilution
Price shall again be adjusted to be the Dilution Price in effect immediately

5

 

prior to such record
date (giving effect to all adjustments that otherwise would be required to be made pursuant to this
Section 3 from and after such record date).

          (b) Issuance of Rights to Purchase Common Stock Below Dilution Price. If the Company
shall, at any time or from time to time after the date hereof, fix a record date for the issuance
of rights, options or warrants to all holders of Common Stock entitling them to subscribe for or
purchase Common Stock, or securities convertible into or exchangeable for Common Stock at a price
per share of Common Stock or having a conversion price per share of Common Stock if a security is
convertible into or exchangeable for Common Stock (determined in either such case by dividing (x)
the total consideration paid and/or payable to the Company upon exercise, conversion or exchange of
such rights, options, warrants or other securities convertible into or exchangeable for Common
Stock by (y) the total number of shares of Common Stock covered by such rights, options, warrants
or other securities convertible into or exchangeable for Common Stock) which is lower than the
Dilution Price, then the Dilution Price shall be reduced to the price per share of the Common Stock
to be so offered (or the initial conversion price of the convertible
securities to be so offered) as determined under clauses (x) and (y) above, provided,
however, if either a Successful Superiority Trial has been completed or the issuance of the
securities contemplated in this section is being effected at least six months after the completion
of a Qualified Subsequent Investment, then (I) the Dilution Price in effect immediately prior to
the issuance of such securities shall first be reduced to the price which is the greater of (A) the
price per share of such Common Stock (as determined pursuant to clauses (x) and (y)) and (B) the
price computed by dividing forty million by the number of shares of Common Stock outstanding
immediately prior to the issuance of the securities (after giving effect to the full exercise,
conversion or exchange, as applicable of such securities and all other securities of the Company
outstanding) (the price so determined under this clause (B), the “Base Dilution Price”), and (II)
if the Dilution Price is reduced pursuant to clause ((I)(B), the Dilution Price shall be further
reduced so that it shall equal the price determined by multiplying Base Dilution Price by a
fraction the numerator of which shall be the number of shares of Common Stock outstanding
immediately prior to the issuance of the securities contemplated in this section plus the number of
shares of Common Stock which the aggregate consideration received for the issuance of the
securities would purchase at the Base Dilution Price, and the denominator of which shall be the
number of shares of Common Stock outstanding immediately after the issuance of the securities
(after giving effect to the full exercise, conversion or exchange, as applicable, of such
securities and all other securities of the Company outstanding; provided, further,
however, that such adjustment shall be made only if such adjustment results in an Dilution
Price which is lower than the Dilution Price in effect immediately prior to such record date. In
case such price for subscription or purchase may be paid in a consideration part or all of which
shall be in a form other than cash, the value of such consideration shall be determined in good
faith by the Board. Any such adjustment shall become effective immediately after the record date
for such rights or warrants. Such adjustment shall be made successively whenever such a record date
is fixed. If such rights or warrants are not issued, or expire or terminate without the exercise
of such rights or warrants and no securities are issued pursuant thereto, the

6

 

Dilution Price shall
be adjusted to the Dilution Price that otherwise would be in effect but for the fact that such
record date had been fixed.

          (c) Certain Distributions. If the Company shall, at any time or from time to time, fix
a record date for the distribution to all holders of Common Stock (including any such distribution
made in connection with a consolidation or merger in which the Company is the continuing
corporation) of evidences of indebtedness, assets or other property (other than regularly scheduled
cash dividends or cash distributions payable out of consolidated earnings or earned surplus or
dividends payable in capital stock for which adjustment is made under Subsection 3(a)) or
subscription rights, options or warrants (excluding those referred to in Subsection 3(b)), then the
number and kind of shares of capital stock or other property issuable on such date shall be
proportionately adjusted so that the Holder of any Warrant exercised after such date shall be
entitled to receive, upon payment of the same aggregate amount as would have been payable before
such date, the aggregate number and kind of shares of capital stock and other property which, if
such Warrant had been exercised immediately prior to such record date, such Holder would have owned
upon such exercise and been entitled to receive by virtue of such distribution. Any such
adjustment shall become effective immediately after the record date for such distribution. Such
adjustments shall be made successively whenever such a record date is
fixed. In the event that such distribution is not so made, the number of shares of Common
Stock or other property which may be received upon exercise of this Warrant shall be adjusted to
the number in effect immediately prior to such record date (giving effect to all adjustments that
otherwise would be required to be made pursuant to this Section 3 from and after such record date).

          (d) Issuance of Common Stock Below Dilution Price.

               (i) If the Company shall, at any time and from time to time, after the date hereof, directly
or indirectly, sell or issue shares of Common Stock (regardless of whether originally issued or
from the Company’s treasury), or rights, options, warrants or convertible or exchangeable
securities containing the right to subscribe for or purchase shares of Common Stock) at a price per
share of Common Stock (determined, in the case of rights, options, warrants or convertible or
exchangeable securities (collectively, “Securities”), by dividing (x) the total consideration
received or receivable by the Company in consideration of the sale or issuance of such Securities,
plus the total consideration payable to the Company upon exercise or conversion or exchange
thereof, by (y) the total number of shares of Common Stock covered by such Securities) which is
lower than the Dilution Price in effect immediately prior to such sale or issuance, then, subject
to clause 3(d)(ii), the Dilution Price shall be reduced to the consideration received (in the case
of Securities, determined as provided herein) per share of Common Stock with respect to such sale
or issuance; provided, however, if either a Successful Superiority Trial has been
completed or the issuance of the securities contemplated in this section is being effected at least
six months after the completion of a Qualified Subsequent Investment, then (I) the Dilution Price
in effect immediately prior to the issuance of such Securities shall first be reduced to the price
which is the greater of (A) the price per share of such Common Stock (as determined pursuant to
clauses (x) and (y)) and (B) the Base Dilution Price and (II) if the Dilution Price is

7

 

reduced
pursuant to clause ((I)(B), the Dilution Price shall be further reduced so that it shall equal the
price determined by multiplying Base Dilution Price by a fraction the numerator of which shall be
the number of shares of Common Stock outstanding immediately prior to the issuance of the
Securities contemplated in this section plus the number of shares of Common Stock which the
aggregate consideration received for the issuance of the Securities would purchase at the Base
Dilution Price, and the denominator of which shall be the number of shares of Common Stock
outstanding immediately after the issuance of the Securities (after giving effect to the full
exercise, conversion or exchange, as applicable, of such securities and all other securities of the
Company outstanding; provided, further, however that such adjustment shall be made only if such
adjustment results in an Dilution Price which is lower than the Dilution Price in effect
immediately prior to taking such action. Such adjustment shall be made successively whenever such
sale or issuance is made. For the purposes of such adjustments, the shares of Common Stock which
the holder of any such Securities shall be entitled to subscribe for or purchase shall be deemed to
be issued and outstanding as of the date of such sale or issuance of such Securities and the
consideration “received” by the Company therefor shall be deemed to be the consideration actually
received or receivable by the Company (plus any underwriting discounts or commissions in connection
therewith) for such Securities, plus the consideration stated in such Securities to be payable to
the Company for the shares of Common Stock covered thereby. If the Company shall
sell or issue shares of Common Stock for a consideration consisting, in whole or in part, of
property other than cash or its equivalent, then in determining the “price per share of Common
Stock” and the “consideration” received or receivable by or payable to the Company for purposes of
the first sentence and the immediately preceding sentence of this Subsection 3(d)(i), the fair
value of such property shall be determined in good faith by the Board. Except as provided below,
the determination of whether any adjustment is required under this Subsection 3(d)(i) by reason of
the sale or issuance of Securities and the amount of such adjustment, if any, shall be made only at
the time of such issuance or sale and not at the subsequent time of issuance of shares of Common
Stock upon the exercise, conversion or exchange of such Securities.

               (ii) No adjustment shall be made to the Dilution Price pursuant to clause 3(d)(i) in
connection with the issuance of (A) shares issued in any of the transactions described in
Subsections 3(a), (b) and (c) hereof; (B) shares issued upon exercise of this Warrant; (C) shares
issued upon conversion of the Series A Convertible Preferred Stock of the Company, or the Series B
Convertible Preferred Stock (the “Convertible Preferred Stock”); or (D) options to purchase an
aggregate of 1,248,500 additional shares of Common Stock pursuant to any stock option or stock plan
or arrangement of the Company in effect on the date hereof, as amended or supplemented after the
date hereof, granted at an exercise price of not less than the Current Market Price of Common Stock
at the time of grant.

               (iii) Notwithstanding any provision in this Section 3 to the contrary and without limitation
to any other provision contained in this Section 3, in the event any securities of the Company
(other than this Warrant or the Convertible Preferred Stock, including, without limitation, those
securities set forth as exceptions in Subsection 3(d)(ii) (for purposes of this

8

 

Subsection,
collectively, the “Subject Securities”) are amended or otherwise modified by operation of its terms
or otherwise (including, without limitation, by operation of such Subject Securities’ anti-dilution
provisions, other than those anti-dilution provisions contained within the Subject Securities that
are substantially similar to the provisions of Section 3(a) hereof) in any manner whatsoever that
results in (i) the reduction of the exercise, conversion or exchange price of such Subject
Securities payable upon the exercise for, or conversion or exchange into, Common Stock or other
securities exercisable for, or convertible or exchangeable into, Common Stock and/or (ii) such
Subject Securities becoming exercisable for, or convertible or exchangeable into (A) more shares or
dollar amount of such Subject Securities which are, in turn exercisable for, or convertible or
exchangeable into, Common Stock, or (B) more shares of Common Stock, then such amendment or
modification shall be treated for purposes of Section 3 as if the Subject Securities which have
been amended or modified have been terminated and new securities have been issued with the amended
or modified terms. The Company shall make all necessary adjustments (including successive
adjustments if required) to the Dilution Price in accordance with Section 3. Upon the expiration
or termination of the right to exercise, convert or exchange any Securities without any shares of
Common Stock having been issued pursuant to such right, any adjustment to the Dilution Price which
was made upon the issuance of such Securities shall be adjusted to the Dilution Price that
otherwise would be in effect but for the fact of the issuance of such Securities.

               (e) Determination of Current Market Price. For the purpose of any computation under
Subsections (b), (c) or (d) of this Section 3 or any other provision of this Warrant, the Current
Market Price per share of Common Stock on any date shall be deemed to be the average of the daily
Closing Prices per share of Common Stock for the 5 consecutive trading days commencing 7 trading
days before such date. If on any such date the shares of Common Stock are not listed or admitted
for trading on any national securities exchange or quoted by NASDAQ or a similar service, then the
Company, on the one hand, and the Holder, on the other hand, shall each promptly appoint as an
appraiser an individual who shall be a member of a nationally recognized investment banking firm.
Each appraiser shall be instructed to, within 30 days of appointment, determine the Current Market
Price per share of Common Stock which shall be deemed to be equal to the fair market value per
share of Common Stock as of such date. If the two appraisers are unable to agree on the Current
Market Price per share of Common Stock within such 30 day period, then the two appraisers, within
10 days after the end of such 30 day period shall jointly select a third appraiser. The third
appraiser shall, within 30 days of its appointment, determine, in good faith, the Current Market
Price per share of Common Stock and such determination shall be controlling. If any party fails to
appoint an appraiser or if one of the two initial appraisers fails after appointment to submit its
appraisal within the required period, the appraisal submitted by the remaining appraiser shall be
controlling. The cost of the foregoing appraisals shall be shared one-half by the Company and
one-half by the Holder, provided, however, in the event a third appraiser is
utilized and one of the two initial appraisals (but not the other initial appraisal) is greater
than or less than the appraisal by such third appraiser by 10% or more, then the cost of all of the
foregoing appraisals shall be borne by the party who appointed the appraiser who made such initial
appraisal.

9

 

          (f) Adjustment to Purchase Price. Upon each adjustment to the Dilution Price pursuant
to Section 3, the Purchase Price shall be adjusted by multiplying the Purchase Price in effect
immediately prior to such adjustment by a fraction, the numerator of which shall be the Dilution
Price as so adjusted and the denominator of which shall be the Dilution Price in effect immediately
prior to such adjustment.

          (g) Adjustment of Number of Shares Issuable Upon Exercise. Upon each adjustment of the
Dilution Price and the Purchase Price as a result of the calculations made in Subsections 3(a), (b)
or (d), this Warrant shall thereafter evidence the right to receive, at the adjusted Purchase
Price, that number of shares of Common Stock (calculated to the nearest one-hundredth) obtained by
dividing (x) the product of the aggregate number of shares of Common Stock covered by this Warrant
immediately prior to such adjustment and the Purchase Price in effect immediately prior to such
adjustment of the Purchase Price by (y) the Purchase Price in effect immediately after such
adjustment of the Purchase Price.

          (h) De Minimis Adjustments. No adjustment shall be made under this Section 3 if the
amount of such adjustment would result in a change in the Dilution Price per share of less than
$0.05, but in such case any adjustment that would otherwise be required to be made shall be carried
forward and shall be made at the time of and together with the next subsequent adjustment, which
together with any adjustment so carried forward, would result in a change in the Dilution Price of
$0.05 or more per share. Notwithstanding the provisions of the first
sentence of this Subsection 3(h), any adjustment postponed pursuant to this Subsection 3(h)
shall be made no later than the earlier of (i) three years from the date of the transaction that
would, but for the provisions of the first sentence of this Section 3(h), have required such
adjustment, (ii) an Exercise Date or (iii) the Expiration Date.

          (i) Adjustments to Other Shares. In the event that at any time, as a result of an
adjustment made pursuant to Subsection 3(a), the Holder shall become entitled to receive, upon
exercise of this Warrant, any shares of capital stock or other securities of the Company other than
shares of Common Stock, the number of such other shares or securities so receivable upon exercise
of this Warrant shall be subject to adjustment from time to time in a manner and on terms as nearly
equivalent as practicable to the provisions with respect to the shares of Common Stock contained in
Subsections 3(a), (b), (c) and (d), inclusive, and the provisions of Sections 2, 5, 6 and 7 with
respect to the shares of Common Stock shall apply on like terms to any such other shares or
securities.

          (j) Reorganization, Reclassification, Merger and Sale of Assets. If there occurs any
capital reorganization or any reclassification of the Common Stock of the Company, the
consolidation or merger of the Company with or into another Person (other than a merger or
consolidation of the Company in which the Company is the continuing corporation and which does not
result in any reclassification or change of outstanding shares of its Common Stock) or the sale or
conveyance of all or substantially all of the assets of the Company to another Person, then
the Holder will thereafter be entitled to receive, upon the exercise of this Warrant in accordance
with the terms hereof, the same kind and amounts of securities (including shares of

10

 

stock) or other
assets, or both, which were issuable or distributable to the holders of outstanding Common Stock of
the Company upon such reorganization, reclassification, consolidation, merger, sale or conveyance,
in respect of that number of shares of Common Stock then deliverable upon the exercise of this
Warrant if this Warrant had been exercised immediately prior to such reorganization,
reclassification, consolidation, merger, sale or conveyance; and, in any such case, appropriate
adjustments (as determined in good faith by the Board of Directors of the Company) shall be made to
assure that the provisions hereof (including, without limitation, provisions with respect to
changes in, and other adjustments of, the Purchase Price and the Dilution Price) shall thereafter
be applicable, as nearly as reasonably may be practicable, in relation to any securities or other
assets thereafter deliverable upon exercise of this Warrant.

     4. Certificate as to Adjustments. Whenever the Purchase Price, the Dilution Price or
the number of shares of Common Stock issuable, or the securities or other property deliverable,
upon the exercise of this Warrant shall be adjusted pursuant to the provisions hereof, the Company
shall promptly give written notice thereof to the Holder, in accordance with Section 13, in the
form of a certificate signed by the Chairman of the Board, President or one of the Vice Presidents
of the Company, and by the Chief Financial Officer, Treasurer or one of the Assistant Treasurers of
the Company, stating the adjusted Purchase Price and Dilution Price, the number of shares of Common
Stock issuable, or the securities or other property deliverable, upon exercise of the Warrant and
setting forth in reasonable detail the method of calculation and the facts requiring such
adjustment and upon which such calculation is based. Each adjustment shall remain in effect until a
subsequent adjustment is required.

     5. Fractional Shares. Notwithstanding an adjustment pursuant to Section 3(g) in the
number of shares of Common Stock covered by this Warrant or any other provision of this Warrant,
the Company shall not be required to issue fractions of shares upon exercise of this Warrant or to
distribute certificates which evidence fractional shares. In lieu of fractional shares, the Company
may make payment to the Holder, at the time of exercise of this Warrant as herein provided, of an
amount in cash equal to such fraction multiplied by the greater of the Current Market Price of a
share of Common Stock on the Exercise Date and the Dilution Price.

     6. Notice of Proposed Actions. In case the Company shall propose at any time or from
time to time (a) to declare or pay any dividend payable in stock of any class to the holders of
Common Stock or to make any other distribution to the holders of Common Stock (other than a
regularly scheduled cash dividend), (b) to offer to the holders of Common Stock rights or warrants
to subscribe for or to purchase any additional shares of Common Stock or shares of stock of any
class or any other securities, rights, warrants or options, (c) to effect any reclassification of
its Common Stock, (d) to effect any consolidation, merger or sale, transfer or other disposition of
all or substantially all of the property, assets or business of the Company which would, if
consummated, adjust the Purchase Price, the Dilution Price or the securities issuable upon exercise
of the Warrants, (e) to effect the liquidation, dissolution or winding up of the Company, or (f) to
take any other action that would require a vote of the Company’s stockholders, then, in each such
case, the Company shall give to the Holder, in accordance with Section 13, a written notice of such
proposed action, which shall specify (i) the record date for

11

 

the purposes of such stock dividend,
distribution of rights or warrants or vote of the stockholders of the Company, or if a record is
not to be taken, the date as of which the holders of shares of Common Stock of record to be
entitled to such dividend, distribution of rights or warrants, or vote is to be determined, or (ii)
the date on which such reclassification, consolidation, merger, sale, transfer, disposition,
liquidation, dissolution or winding up is expected to become effective, and such notice shall be so
given as promptly as possible but in any event at least ten (10) Business Days prior to the
applicable record, determination or effective date specified in such notice.

     7. No Dilution or Impairment. The Company will not, by amendment of its Certificate of
Incorporation or through any reorganization, transfer of assets, consolidation, merger,
dissolution, issue or sale of securities or any other action, avoid or seek to avoid the observance
or performance of any of the terms of this Warrant, but will at all times in good faith assist in
the carrying out of all such terms and in the taking of all such action as may be necessary or
appropriate in order to protect the rights of the Holder of this Warrant against dilution (other
than the dilutive events covered in Section 3 herein) or other impairment. Without limiting the
generality of the foregoing, the Company (a) will not increase the par value of any shares of stock
receivable on the exercise of this Warrant above the amount payable therefor on such exercise, (b)
will at all times reserve and keep available the maximum number of its authorized shares of Common
Stock, free from all preemptive rights therein, which will be sufficient to permit the full
exercise of this Warrant, and (c) will take all such action as may be necessary or appropriate in
order that all shares of Common Stock as may be issued pursuant to the exercise of this Warrant
will, upon issuance, be duly and validly issued, fully paid and nonassessable, and free from all
taxes, liens and charges as to the holders of the Warrant exercised with respect to the issue
thereof.

     8. Replacement of Warrants. On receipt by the Company of an affidavit of an authorized
representative of the Holder stating the circumstances of the loss, theft, destruction or
mutilation of this Warrant (and in the case of any such mutilation, on surrender and cancellation
of such Warrant), the Company at its expense will promptly execute and deliver, in lieu thereof, a
new Warrant of like tenor which shall be exercisable for a like number of shares of Common Stock.
If required by the Company, such Holder must provide an indemnity bond or other indemnity
sufficient in the judgment of the Company to protect the Company from any loss which it may suffer
if a lost, stolen or destroyed Warrant is replaced.

     9. Restrictions on Transfer.

          (a) Subject to the provisions of this Section 9, this Warrant may be transferred or assigned,
in whole or in part, by the Holder at any time, and from time to time. The term “Holder” as used
herein shall also include any transferee of this Warrant whose name has been recorded by the
Company in the Warrant Register (as hereinafter defined). Each transferee of the Warrant or the
Common Stock issuable upon the exercise of the Warrant acknowledges that the Warrant or the Common
Stock issuable upon the exercise of the Warrant has not been registered under the Securities Act
and may be transferred only pursuant to an effective registration under

12

 

the Securities Act or
pursuant to an applicable exemption from the registration requirements of the Securities Act.

          (b) With respect to a transfer that should occur prior to the time that the Warrant or the
Common Stock issuable upon the exercise thereof is registered under the Securities Act, such Holder
shall request an opinion of counsel (which shall be rendered by counsel reasonably acceptable to
the Company) that the proposed transfer may be effected without registration or qualification under
any Federal or state securities or blue sky law. Counsel shall, as promptly as practicable, notify
the Company and the Holder of such opinion and of the terms and conditions, if any, to be observed
in such transfer, whereupon the Holder shall be entitled to transfer this Warrant or such shares of
Common Stock (or portion thereof), subject to any other provisions and limitations of this Warrant.
In the event this Warrant shall be exercised as an incident to such transfer, such exercise shall
relate back and for all purposes of this Warrant be deemed to have occurred as of the date of such
notice regardless of delays incurred by reason of the provisions of this Section 9 which may result
in the actual exercise on any later date.

          (c) The Company shall maintain a register (the “Warrant Register”) in its principal office for
the purpose of registering the Warrant and any transfer thereof, which register shall reflect and
identify, at all times, the ownership of any interest in the Warrant. Upon the issuance of this
Warrant, the Company shall record the name of the initial purchaser of this Warrant in the Warrant
Register as the first Holder. Upon surrender for registration of transfer or exchange of this
Warrant together with a properly executed Form of Assignment attached hereto as Exhibit B
at the principal office of the Company, the Company shall, at its expense, execute and deliver one
or more new Warrants of like tenor which shall be exercisable for a like aggregate number of
shares of Common Stock, registered in the name of the Holder or a transferee or transferees.

          (d) Intentionally omitted.

     10. No Rights or Liability as a Stockholder. This Warrant does not entitle the Holder
hereof to any voting rights or other rights as a stockholder of the Company. No provisions hereof,
in the absence of affirmative action by the Holder hereof to purchase Common Stock, and no
enumeration herein of the rights or privileges of the Holder shall give rise to any liability of
such Holder as a stockholder of the Company.

     11. Charges, Taxes and Expenses. Issuance of certificates for shares of Common Stock
upon the exercise of this Warrant shall be made without charge to the Holder hereof for any issue
or transfer tax, or other incidental expense, in respect of the issuance or delivery of such
certificates or the securities represented thereby, all of which taxes and expenses shall be paid
by the Company.

     12. Amendment or Waiver. Subject to the terms of the Section 7.5 of the Purchase
Agreement, this Warrant and any term hereof may be amended, waived, discharged or terminated only
by and with the written consent of the Company and the Holder.

13

 

     13. Notices. Any notice or other communication (or delivery) required or permitted
hereunder shall be made in writing and shall be by registered mail, return receipt requested,
telecopier, courier service or personal delivery to the Company at its principal office as
specified in Section 7.3 of the Purchase Agreement and to the Holder at its address as it appears
in the Warrant Register. All such notices and communications (and deliveries) shall be deemed to
have been duly given: when delivered by hand, if personally delivered; when delivered by courier,
if delivered by commercial overnight courier service; five Business Days after being deposited in
the mail, postage prepaid, if mailed; and when receipt is acknowledged, if telecopied.

     14. Certain Remedies. The Holder shall be entitled to an injunction or injunctions to
prevent breaches of the provisions of this Warrant and to enforce specifically the terms and
provisions of this Warrant in any court of the United States or any state thereof having
jurisdiction, this being in addition to any other remedy to which such Holder may be entitled at
law or in equity.

     15. Governing Law. THIS AGREEMENT SHALL BE GOVERNED BY, CONSTRUED IN ACCORDANCE WITH,
AND ENFORCED UNDER, THE LAWS OF THE STATE OF NEW YORK APPLICABLE TO AGREEMENTS OR INSTRUMENTS
ENTERED INTO AND PERFORMED ENTIRELY WITHIN SUCH STATE.

     16. Headings. The headings in this Warrant are for convenience of reference only and
shall not limit or otherwise affect the meaning hereof.

14

 

	 	 	 	 	 
	 	 	BIODEL INC.
	 
	 	 	 	 
	 

	 	By:	 	 
	 

	 	 	 	 
	 

	 	 	 	Name: Solomon S. Steiner
	 

	 	 	 	Title: Chairman and President

 

 

	 	 	 
	 

	 	Exhibit A to Common
	 

	 	Stock Purchase Warrant

FORM OF

ELECTION TO PURCHASE SHARES

     The
undersigned hereby irrevocably elects to exercise the Warrant to purchase                      shares of
Common Stock, par value $0.01per share (“Common Stock”), of Biodel Inc. (the “Company”) and hereby
[makes payment of
$                     therefor] [or] [makes payment therefore by surrendering pursuant to
Section 2(b)(iii)                    
shares of Common Stock of the Company] [or] [makes payment therefor by
cancellation pursuant to Section 2(b)(iv) of a portion of the Warrant with respect to                     
shares of Common Stock]. The undersigned hereby requests that certificates for such shares be
issued and delivered as follows:

	 	 	 
	ISSUE TO:
	 	 
	 

	 	 

(NAME)

 

(ADDRESS, INCLUDING ZIP CODE)

 

(SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER)

	 	 	 
	DELIVER TO:
	 	 
	 

	 	 

(NAME)

 

(ADDRESS, INCLUDING ZIP CODE)

          If the number of shares of Common Stock purchased hereby is less than the number of shares of
Common Stock covered by the Warrant, the undersigned requests that a new Warrant representing the
number of shares of Common Stock not purchased be issued and delivered as follows:

	 	 	 
	ISSUE TO:
	 	 
	 

	 	 

(NAME OF HOLDER)

 

(ADDRESS, INCLUDING ZIP CODE)

	 	 	 
	DELIVER TO:
	 	 
	 

	 	 

(NAME OF HOLDER)

 

(ADDRESS, INCLUDING ZIP CODE)

	 	 	 	 	 
	Dated:                                        	 	[NAME OF HOLDER]
	 
	 	 	 	 
	 

	 	By:	 	 
	 

	 	 	 	 
	 

	 	 	 	Name:
	 

	 	 	 	Title:

 

			
	1	 	Name of Holder must conform in all respects to name of Holder as specified on the face
of the Warrant.

 

 

	 	 	 
	 

	 	Exhibit B to Common
	 

	 	Stock Purchase Warrant

FORM OF ASSIGNMENT

          FOR VALUE RECEIVED, the undersigned hereby sells, assigns, and transfers unto the Assignee
named below all of the rights of the undersigned to purchase Common Stock, par value $0.01 per
share (“Common Stock”), of BIODEL INC. represented by the Warrant, with respect to the number of
shares of Common Stock set forth below:

Name of Assignee           Address            No. of Shares

and does hereby irrevocably constitute and appoint                                                              Attorney to make
such transfer on the books of BIODEL, INC. maintained for that purpose, with full power of
substitution in the premises.

	 	 	 	 	 
	Dated:                                        	 	[NAME OF HOLDER1]
	 
	 	 	 	 
	 

	 	By:	 	 
	 

	 	 	 	 
	 

	 	 	 	Name:
	 

	 	 	 	Title:

 

			
	1	 	Name of Holder must conform in all respects to name of Holder as specified on the face of the
Warrant.

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