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Exhibit 4.6

SECOND AMENDMENT
TO THE
CARDINAL HEALTH 401(K) SAVINGS PLAN
(As Amended and Restated January 1, 2020)

Background Information

A.    Cardinal Health, Inc. (“Cardinal Health”) previously adopted and currently maintains the Cardinal Health 401(k) Savings Plan (the “Plan”) for the benefit of employees of Cardinal Health and its subsidiaries and affiliates.

B.    Section 12.02 of the Plan provides that the Plan may be amended at any time through a written resolution adopted or approved by the Financial Benefit Plans Committee (“FBPC”) with respect to any amendment that (i) is required by law to maintain the tax-qualified status of the Plan, or (ii) when aggregated with any other amendment or amendments approved on the same date, is reasonably expected to have an annual financial impact on Cardinal Health of $5 million or less.

C.    The FBPC has concluded that the amendment set forth below (i) is required by law to maintain the tax-qualified status of the Plan, and (ii) when aggregated with any other amendments set to be approved on the same date, is reasonably expected to have an annual financial impact on Cardinal Health of less than $5 million.

D.    The FBPC desires to amend the Plan to implement certain changes to the rules governing hardship distributions under the Plan, pursuant to changes in law contained in the Bipartisan Budget Act of 2018 and related Treasury Regulations.

Amendment of the Cardinal Health 401(k) Savings Plan

The Plan is hereby amended as set forth below, effective as of January 1, 2019.

1.    Section 6.01(A) of the Plan is hereby amended by striking the “or” at the end of subsections 6.01(A)(iv) and 6.01(A)(vi), renumbering subsection 6.01(A)(vii) as subsection 6.01(A)(viii), and inserting the following new subsection 6.01(A)(vii):

“(vii)    Expenses and losses (including loss of income) incurred by the Participant on account of a disaster declared by the Federal Emergency Management Agency (FEMA) under the Robert T. Stafford Disaster Relief and Emergency Assistance Act, provided that the employee’s principal residence or principal place of employment at the time of the disaster was located in an area designated by FEMA for individual assistance with respect to the disaster; or”

2.    Section 6.01(B) of the Plan is hereby amended in its entirety as follows:

“B.    A distribution will be considered to be necessary to satisfy an immediate and heavy financial need of the Participant only if:

(i)    The Participant has obtained all distributions other than hardship distributions, and all nontaxable loans, currently available under all plans maintained by the Employer; and

(ii)    The distribution is not in excess of the amount necessary to satisfy the immediate and heavy financial need, including any amounts necessary to pay any federal, state, or local income taxes or penalties reasonably anticipated to result from the distribution.  A distribution will not be treated as necessary to satisfy an immediate and heavy financial need unless each of the following requirements is satisfied:

a.    The Participant has obtained all other currently available distributions (including distributions of ESOP dividends under Code Section 404(k), but not hardship distributions) under the Plan and all other deferred compensation plans, whether qualified or nonqualified, maintained by the Company;

b.    The Participant has provided to the Plan Administrator (or its designee) a representation in writing (including by using an electronic medium as defined in Treasury Regulation Section 1.401(a)-21(e)(3)), or in such other form as may be permitted in guidance issued by the Internal Revenue Service, that he or she has insufficient cash or other liquid assets reasonably available to satisfy the need; and

c.    The Plan Administrator does not have actual knowledge that is contrary to the representation described in Section 6.01(B)(ii)(b).”

3.    All other provisions of the Plan shall remain in full force and effect.

CARDINAL HEALTH, INC.
FINANCIAL BENEFIT PLANS COMMITTEE

By:      /s/ Kendell F. Sherrer            

Its:      VP, Compensation and Benefits    

Date:      February 22, 2021Document

Exhibit 4.7

THIRD AMENDMENT
TO THE
CARDINAL HEALTH 401(K) SAVINGS PLAN
(As Amended and Restated January 1, 2020)

Background Information

A.    Cardinal Health, Inc. (“Cardinal Health”) previously adopted and currently maintains the Cardinal Health 401(k) Savings Plan (the “Plan”) for the benefit of employees of Cardinal Health and its subsidiaries and affiliates.

B.    Section 12.02 of the Plan provides that the Plan may be amended at any time through a written resolution adopted or approved by the Financial Benefit Plans Committee (“FBPC”) with respect to any amendment that, when aggregated with any other amendment or amendments approved on the same date, is reasonably expected to have an annual financial impact on Cardinal Health of $5 million or less.

C.    The FBPC has concluded that the amendment set forth below, when aggregated with any other amendments set to be approved on the same date, is reasonably expected to have an annual financial impact on Cardinal Health of less than $5 million.

D.    The FBPC desires to amend the Plan to provide that certain participants who terminate employment in connection with the divestiture of Cardinal Health’s Cordis business shall become fully vested in any Employer Contributions and/or Special Contributions, to the extent not already fully vested.

Amendment of the Cardinal Health 401(k) Savings Plan

The Plan is hereby amended as set forth below, effective as of August 2, 2021.

1.    Section 4.01 of the Plan is hereby amended by adding a new subsection C to the end thereof, to read as follows:

“C.    Special Rule for Cordis Employees.  Notwithstanding the foregoing provisions of Section 4.01 or any other provision of the Plan, a Participant who becomes an employee of Bayou Purchaser, Inc. or a subsidiary thereof (and thereby terminates employment from the Employer) as a result of the Company’s sale of its Cordis business shall become 100% vested in his or her Employer Contribution Account and Special Contribution Account, as applicable, as of August 2, 2021, or as of such other closing date of the Company’s sale of its Cordis business.”

2.    All other provisions of the Plan shall remain in full force and effect.

CARDINAL HEALTH, INC.
FINANCIAL BENEFIT PLANS COMMITTEE

By:      Kendell Sherrer            

Its:      VP, Compensation and Benefits

Date:      July 28, 2021Document

Exhibit 4.8

FOURTH AMENDMENT
TO THE 
CARDINAL HEALTH 401(K) SAVINGS PLAN
(As Amended and Restated January 1, 2020)

Background Information

A.    Cardinal Health, Inc. (“Cardinal Health”) previously adopted and currently maintains the Cardinal Health 401(k) Savings Plan (the “Plan”) for the benefit of employees of Cardinal Health and its subsidiaries and affiliates. 

B.    Section 12.02 of the Plan provides that the Plan may be amended at any time through a written resolution adopted or approved by the Financial Benefit Plans Committee (“FPBC”) with respect to any amendment that (i) is required by law to maintain the tax-qualified status of the Plan, or (ii) when aggregated with any other amendment or amendments approved on the same date, is reasonably expected to have an annual financial impact on the Company of $5 million or less. 

C.    The FBPC has concluded that the amendment set forth below (i) is required by law to maintain the tax-qualified status of the Plan, and (ii) when aggregated with any other amendments set to be approved on the same date, is reasonably expected to have an annual financial impact of Cardinal Health of less than $5 million.

D.    The FBPC desires to amend the Plan to: (1) clarify the Plan’s provisions governing the allocation of forfeitures; (2) implement certain changes in law pursuant to the Coronavirus Aid, Relief, and Economic Security (CARES) Act, and related guidance issued by the Internal Revenue Service; and (3) update the Plan’s loan provisions with respect to participants who terminate employment while a Plan loan is outstanding. 

Amendment of the Cardinal Health 401(k) Savings Plan

The Plan is hereby amended as set forth below, effective as of the dates set forth below.

1.    Effective January 1, 2021, Section 3.12 of the Plan is hereby amended in its entirety to read as follows:

“Section 3.12        ALLOCATION OF FORFEITURES.  Subject to any restoration allocation required under Section 4.05, the Plan Administrator shall allocate and use the amount of a Participant’s benefit forfeited under the Plan either to pay reasonable expenses of the Plan (to the extent not paid by the Employer) or to reduce Employer Contributions, Special Contributions, Matching Contributions and/or other contributions payable under the Plan, as determined by the Plan Administrator, for the Plan Year in which the forfeiture occurs.” 

2.    Effective January 1, 2020, Section 5.05 of the Plan is amended by adding a new subsection J to the end thereof, to read as follows:

“J.    Suspension of 2020 Required Minimum Distributions.  Notwithstanding anything in this Section 5.05 to the contrary, a Participant or Beneficiary who would have been required to receive required minimum distributions for the 2020 Plan Year but for the enactment of Code Section 401(a)(9)(I) 

of the Code (“2020 RMDs”), and who would have satisfied that requirement by receiving distributions that are (1) equal to the 2020 RMDs or (2) one or more payments (that include the 2020 RMDs) in a series of substantially equal periodic payments made at least annually and expected to last for the life (or life expectancy) of the Participant, the joint lives (or joint life expectancies) of the Participant and the Participant’s designated Beneficiary, or for a period of at least ten years, will not receive those distributions, unless the Participant or Beneficiary affirmatively elects to receive the distribution (which includes an election prior to April 1, 2020 for a 2020 RMD payment on a specific date in 2020). A direct rollover will be offered only for distributions (excluding any portion comprising the 2020 RMDs) that would be eligible rollover distributions in the absence of Code Section 401(a)(9)(I).”

3.    Effective May 24, 2021, the third sentence of Section 6.06(E)(i) of the Plan is hereby amended to read as follows:

“However, notwithstanding the foregoing provisions of this Section 6.06(E), if a Participant is terminated from employment, the Participant may continue to make loan payments on any loan balance outstanding at the time of such termination according to the rules and procedures adopted by the Plan Administrator.”

4.    Effective April 13, 2020, a new Section 6.08 is added to the Plan to read as follows:

“Section 6.08        CORONAVIRUS-RELATED DISTRIBUTIONS.  Notwithstanding any other provision to the contrary, the following special rules apply to any Participant who is an Affected Individual who received a Coronavirus-Related Distribution.

A.    A Coronavirus-Related Distribution shall be treated as meeting the requirements of Code Section 401(k)(2)(B)(i) and shall not be subject to the tax treatment that applies to an Eligible Rollover Distribution (as defined in Section 6.05(B) of the Plan).

B.    Code Section 72(t) shall not apply to any Coronavirus-Related Distribution.  Unless the Affected Individual elects otherwise, any Coronavirus-Related Distribution that would be included in the Affected Individual’s gross income for the taxable year of the distribution shall be included in gross income ratably over a three-year period beginning in the year of the distribution.

C.    The aggregate amount of Coronavirus-Related Distributions shall not exceed (i) $100,000 or (ii) the amount of an Affected Individual’s Nonforfeitable Account Balance.

D.    An Affected Individual who received a Coronavirus-Related Distribution may, at any time during the three-year period beginning on the day after receipt of the Coronavirus-Related Distribution, make one or more repayments to the Plan in an aggregate amount not to exceed the amount of the Coronavirus-Related Distribution.  Amounts repaid hereunder shall be treated as trustee-to-trustee 

transfers within 60 days of the distribution and shall be credited to the Affected Individual’s Rollover Account.

E.    An Affected Individual will certify, in accordance with the rules prescribed by the Plan Administrator, that he or she meets the requirements of an Affected Individual, and the Plan Administrator (or its delegate, as applicable) may rely on such certification.

F.    Definitions. For purposes of this Section 6.08, the following definitions shall apply:

(i)    “Coronavirus-Related Distribution” means any distribution on or after January 1, 2020 and before December 31, 2020 made to an Affected Individual.

(ii)    “Affected Individual” means a Participant who satisfies at least one of the following conditions: (a) he or she is diagnosed with the virus SARS-CoV-2 or with COVID-19 by a test approved by the Centers for Disease Control and Prevention (“CDC”); (b) his or her Spouse or dependent is diagnosed with SARS-CoV-2 or with COVID-19 by a test approved by the CDC; (c) he or she, his or her Spouse, or a member of his or her household (as defined below) experiences adverse financial consequences as a result of being quarantined, being furloughed, being laid off, having his or her work hours reduced due to SARS-CoV-2 or COVID-19, being unable to work due to lack of child care due to SARS-CoV-2 or COVID-19; or (d) the closing or reduction of hours of his or her business due to SARS-CoV-2 or COVID-19, or other factors as determined by the Secretary of the Treasury (or the Secretary’s delegate). For purposes of this Section 6.08(F)(ii), a member of a Participant’s household is someone who shares the Participant’s principal residence.”

5.    Effective April 13, 2020, a new Section 6.09 is added to the Plan to read as follows:

“Section 6.09     CORONAVIRUS RELATED LOANS.  Notwithstanding any other provision of the Plan to the contrary, the following special rules apply to loans made to any Participant who is an Affected Individual, as defined in Section 6.08(F)(ii) of the Plan.

A.    The amount of any loan from the Plan during the Applicable Loan Period may not, when added to the outstanding balance of all loans made to such Participant who is an Affected Individual, exceed the lesser of $100,000 or one hundred percent (100%) of the Participant’s Nonforfeitable Account Balance.  The $100,000 limit described in the preceding sentence shall be reduced by the excess (if any) of the highest outstanding balance of loans from the Plan during the one-year period ending on the day before the date on which such loan was made, over the outstanding balance of loans on the date on which such loan was made.  For purposes of 

the above limitation, all loans from all plans of the Employer and any Related Employer, are aggregated.  For purposes of this Section 6.09, the Participant’s Nonforfeitable Account Balance is determined as of the Valuation Date coinciding with or next preceding the date on which a properly completed request for a Coronavirus Related Loan is received by the Plan Administrator (or its delegate) or the Trustee, as applicable.

B.    For an Affected Individual with an outstanding loan on or after the Qualified Beginning Date, the due date of any loan repayment that is due during the period beginning on the Qualified Beginning Date and ending on December 31, 2020 may be delayed for up to one year.  Any subsequent repayment with respect to such loan shall be adjusted to reflect the delay and any interest accruing during such delay.  The five-year loan repayment schedule required under Code Section 72(p) shall be appropriately adjusted to reflect the period during which loan payments are delayed.

C.    For purposes of this Section 6.09, the following definitions shall apply:

(i)    “Applicable Loan Period” means the period beginning on March 27, 2020 and ending on September 22, 2020.

(ii)    “Qualified Beginning Date” means March 27, 2020.”

6.    All other provisions of the Plan shall remain in full force and effect.

CARDINAL HEALTH, INC.
FINANCIAL BENEFIT PLANS COMMITTEE

By:        /s/ Kendell F. Sherrer        
        Kendell F. Sherrer

Its:        VP, Compensation and Benefits

Date:        December 22, 2021

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