Document:

<PAGE>
                                                                     Exhibit 4.9

                                                                  EXECUTION COPY

                                    AMENDMENT

          THIS AMENDMENT (this "AMENDMENT") to the Stock Purchase Warrant dated
as of August 14, 2000 (the "STOCK PURCHASE WARRANT"), is made and entered into
as of August 26, 2005 by and among EpiCept Corporation, a Delaware corporation
(the "COMPANY"), and Alpinvest International B.V. (the "HOLDER"). Capitalized
terms used herein without definition shall have their respective meanings
assigned in the Stock Purchase Warrant.

          WHEREAS, the Company issued the Stock Purchase Warrant to the Holder
in connection with a convertible term note in the aggregate principal amount of
$1,000,000 in August 2000; and

          WHEREAS, the Company and the Holder desire to amend the Stock Purchase
Warrant to provide for the automatic exercise of such warrant by the net
issuance method described in the Stock Purchase Warrant immediately prior to the
Effective Time (as defined in the Merger Agreement) of the merger (the "MERGER")
of a wholly owned subsidiary of the Company with and into Maxim Pharmaceuticals,
Inc. ("MAXIM") pursuant to an Agreement and Plan of Merger among the Company,
Magazine Acquisition Corp. and Maxim (the "MERGER AGREEMENT").

          NOW, THEREFORE, the parties hereto, in consideration of the premises
and their mutual covenants and agreements herein set forth, and intending to be
legally bound hereby, covenant and agree as follow:

                                    ARTICLE 1

                                   AMENDMENTS

     1.1 Amendment to Title. The title of the Stock Purchase Warrant is hereby
amended in its entirety to read as follows:

          "Amended and Restated Stock Purchase Warrant."

     1.2 Amendment to Section 1. A new Section 1(f) is hereby added to Section 1
to read as follows:

          "(f) Effective immediately prior to the Effective Time of the Merger,
          without further act on the part of the Holder, this Warrant shall be
          deemed to be exercised for the number of shares of Common Stock
          calculated pursuant to Section 6 hereof. Payment of the Exercise Price
          shall be deemed made by the net issuance method described in Section
          3(b) hereof."

     1.3 Amendment to Section 3. A new clause (iv) is hereby added to the last
paragraph of Section 3 to read as follows:

          "In connection with a deemed exercise of this Warrant upon
     consummation of the Merger, the current fair market value of Common Stock
     shall be $1.81."
<PAGE>
                                    ARTICLE 2

                                  MISCELLANEOUS

     2.1 Counterparts. This Amendment may be executed in more than one
counterpart, each of which shall be deemed to be an original and which,
together, shall constitute one and the same instrument Any such counterpart may
contain one or more signature pages.

     2.2 Governing Law. THIS AMENDMENT SHALL BE GOVERNED BY, AND CONSTRUED AND
ENFORCED IN ACCORDANCE WITH, THE SUBSTANTIVE LAWS OF THE STATE OF DELAWARE,
WITHOUT REGARD TO ITS PRINCIPLES OF CONFLICTS OF LAW.

     2.3 Confirmation. This Amendment and the Convertible Notes shall henceforth
be read together. Except as expressly set forth herein, the Convertible Notes
shall remain unchanged and is in all respect confirmed and preserved.

     2.4 Severability. In case any provision in this Amendment shall be held
invalid, illegal, or unenforceable in any respect for any reason, the validity,
legality, and enforceability of any such provision in every other respect and
the remaining provisions shall not in any way be affected or impaired thereby.

     2.5 Facsimile Signatures. This Amendment may be executed and delivered by
facsimile and upon such delivery the facsimile signature will be deemed to have
the same effect as if the original signature had been delivered to the other
party.

     2.6 Headings. Article, section and subsection headings in this Amendment
are included for convenience of reference only and shall not constitute a part
of this Amendment for any other purpose.

                                      *****

            [THE REMAINDER OF THIS PAGE IS INTENTIONALLY LEFT BLANK]
<PAGE>
     IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be
duly executed as of the date first written above.

                                        THE COMPANY:

                                        EPICEPT CORPORATION

                                        By: /s/ John V. Talley
                                            ------------------------------------
                                        Name: John V. Talley
                                        Title: Chief Executive Officer
<PAGE>
NIBC Principal Instruments IV B.V.,
represented by:

By: Alpinvest Partners N.V. (proxy)

By: /s/ E.M.J. Thyssen
    ---------------------------------
Name: Managing Partner
Title:
       ------------------------------

Address:
         ----------------------------

                               EPICEPT CORPORATION
                       AMENDMENT TO THE ALPINVEST WARRANT
                                 SIGNATURE PAGE<PAGE>
                                                                    Exhibit 4.11

                                                                  EXECUTION COPY

                                    AMENDMENT

          THIS AMENDMENT (this "AMENDMENT") to the Stock Purchase Warrant dated
as of August 9, 2000 (the "STOCK PURCHASE WARRANT"), is made and entered into as
of August 26, 2005 by and among EpiCept Corporation, a Delaware corporation (the
"COMPANY"), and TVM III Limited Partnership (formerly known as TVM Techno
Venture Enterprises No. III Limited Partnership) (the "HOLDER"). Capitalized
terms used herein without definition shall have their respective meanings
assigned in the Stock Purchase Warrant.

          WHEREAS, the Company issued the Stock Purchase Warrant to the Holder
in connection with a convertible term note in the aggregate principal amount of
$1,000,000 in August 2000; and

          WHEREAS, the Company and the Holder desire to amend the Stock Purchase
Warrant to provide for the automatic exercise of such warrant by the net
issuance method described in the Stock Purchase Warrant immediately prior to the
Effective Time (as defined in the Merger Agreement) of the merger (the "MERGER")
of a wholly owned subsidiary of the Company with and into Maxim Pharmaceuticals,
Inc. ("MAXIM") pursuant to an Agreement and Plan of Merger among the Company,
Magazine Acquisition Corp. and Maxim (the "MERGER AGREEMENT").

          NOW, THEREFORE, the parties hereto, in consideration of the premises
and their mutual covenants and agreements herein set forth, and intending to be
legally bound hereby, covenant and agree as follow:

                                    ARTICLE 1

                                   AMENDMENTS

     1.1 Amendment to Title. The title of the Stock Purchase Warrant is hereby
amended in its entirety to read as follows:

          "Amended and Restated Stock Purchase Warrant."

     1.2 Amendment to Section 1. A new Section 1(f) is hereby added to Section 1
to read as follows:

          "(f) Effective immediately prior to the Effective Time of the Merger,
          without further act on the part of the Holder, this Warrant shall be
          deemed to be exercised for the number of shares of Common Stock
          calculated pursuant to Section 6 hereof. Payment of the Exercise Price
          shall be deemed made by the net issuance method described in Section
          3(b) hereof."

     1.3 Amendment to Section 3. A new clause (iv) is hereby added to the last
paragraph of Section 3 to read as follows:

          "In connection with a deemed exercise of this Warrant upon
     consummation of the Merger, the current fair market value of Common Stock
     shall be $1.81."
<PAGE>
                                    ARTICLE 2

                                  MISCELLANEOUS

     2.1 Counterparts. This Amendment may be executed in more than one
counterpart, each of which shall be deemed to be an original and which,
together, shall constitute one and the same instrument Any such counterpart may
contain one or more signature pages.

     2.2 Governing Law. THIS AMENDMENT SHALL BE GOVERNED BY, AND CONSTRUED AND
ENFORCED IN ACCORDANCE WITH, THE SUBSTANTIVE LAWS OF THE STATE OF DELAWARE,
WITHOUT REGARD TO ITS PRINCIPLES OF CONFLICTS OF LAW.

     2.3 Confirmation. This Amendment and the Convertible Notes shall henceforth
be read together. Except as expressly set forth herein, the Convertible Notes
shall remain unchanged and is in all respect confirmed and preserved.

     2.4 Severability. In case any provision in this Amendment shall be held
invalid, illegal, or unenforceable in any respect for any reason, the validity,
legality, and enforceability of any such provision in every other respect and
the remaining provisions shall not in any way be affected or impaired thereby.

     2.5 Facsimile Signatures. This Amendment may be executed and delivered by
facsimile and upon such delivery the facsimile signature will be deemed to have
the same effect as if the original signature had been delivered to the other
party.

     2.6 Headings. Article, section and subsection headings in this Amendment
are included for convenience of reference only and shall not constitute a part
of this Amendment for any other purpose.

                                      *****

            [THE REMAINDER OF THIS PAGE IS INTENTIONALLY LEFT BLANK]
<PAGE>
     IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be
duly executed as of the date first written above.

                                        THE COMPANY:

                                        EPICEPT CORPORATION

                                        By: /s/ John V. Talley
                                            ------------------------------------
                                        Name: John V. Talley
                                        Title: Chief Executive Officer
<PAGE>
TVM III LIMITED PARTNERSHIP

By: /s/ John J. DiBello
    ---------------------------------
Name: John J. DiBello
Title: Managing Limited Partner

Address:

101 Arch Street
Boston, Massachusetts

                               EPICEPT CORPORATION
                        AMENDMENT TO THE TVM III WARRANT
                                 SIGNATURE PAGE

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