Document:

exv10w8

 

Exhibit 10.8

Exclusive License Agreement

between

The Regents of the University of California

and

The Foundry, LLC

for

“Embolism Retrieval Device”

Case No. LA96-517-03/04

 

 

TABLE OF CONTENTS

	 	 	 	 	 	 	 	 	 
	Article No.	 	Title	 	 	Page
	RECITALS	 	 	1	 
	 	1.	 	 	DEFINITIONS
	 	 	1	 
	 	2.	 	 	GRANT
	 	 	2	 
	 	3.	 	 	SUBLICENSES
	 	 	2	 
	 	4.	 	 	FEES
	 	 	3	 
	 	5.	 	 	ROYALTIES
	 	 	3	 
	 	6.	 	 	DILIGENCE
	 	 	5	 
	 	7.	 	 	PATENT FILING, PROSECUTION AND MAINTENANCE
	 	 	5	 
	 	8.	 	 	PATENT INFRINGEMENT
	 	 	6	 
	 	9.	 	 	PROGRESS AND ROYALTY REPORTS
	 	 	7	 
	 	10.	 	 	BOOKS AND RECORDS
	 	 	8	 
	 	11.	 	 	LIFE OF THE AGREEMENT
	 	 	8	 
	 	12.	 	 	TERMINATION BY THE REGENTS
	 	 	8	 
	 	13.	 	 	TERMINATION BY LICENSEE
	 	 	8	 
	 	14.	 	 	DISPOSITION OF LICENSED PRODUCTS ON HAND UPON TERMINATION
	 	 	9	 
	 	15.	 	 	PATENT MARKING
	 	 	9	 
	 	16.	 	 	USE OF NAMES AND TRADEMARKS AND NONDISCLOSURE OF AGREEMENT
	 	 	9	 
	 	17.	 	 	LIMITED WARRANTY
	 	 	9	 
	 	18.	 	 	INDEMNIFICATION
	 	 	10	 
	 	19.	 	 	NOTICES
	 	 	11	 
	 	20.	 	 	ASSIGNABILITY
	 	 	11	 
	 	21.	 	 	LATE PAYMENTS
	 	 	11	 
	 	22.	 	 	WAIVER
	 	 	11	 
	 	23.	 	 	GOVERNING LAWS
	 	 	11	 
	 	24.	 	 	GOVERNMENT APPROVAL OR REGISTRATION
	 	 	11	 
	 	25.	 	 	EXPORT CONTROL LAWS
	 	 	12	 
	 	26.	 	 	FORCE MAJEURE
	 	 	12	 
	 	27.	 	 	CONFIDENTIALITY
	 	 	12	 
	 	28.	 	 	MISCELLANEOUS
	 	 	13	 
	 	 	 	 	APPENDIX A
	 	 	14	 

 

 

LICENSE AGREEMENT

This Agreement is made and is effective this  29th day of November
1999, (the “Effective Date”) between THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (“The Regents”), a
California corporation having its corporate offices located at 1111 Franklin Street, Oakland,
California 94607-5200, acting through its offices located at Box 140607, 10945 Le Conte Avenue,
Suite 1401, Los Angeles, California 90095-1406, and Foundry, LLC. (“Licensee”), having a principal
place of business at 604-D Fifth Ave., Redwood City, CA 94063.

RECITALS

WHEREAS, a certain invention (the “Invention”), generally characterized as “Embolism Retrieval
Device” (UCLA Case No. LA96-517-03/04), was made in the course of research at the University of
California, Los Angeles by Dr. Pierre Gobin and Dr. J. P. Wensel and is covered by Regents’ Patent
Rights as defined below;

WHEREAS, Licensee and The Regents entered into a Secrecy Agreement effective August 13, 1999 and
expiring on August 13, 2004 to allow Licensee to evaluate its interest in the Invention and, as a
result of its evaluation, Licensee wishes to obtain certain rights from The Regents;

WHEREAS, Licensee is a “small business firm” as defined in 15 U.S.C. §42; and

WHEREAS, The Regents wishes that Regents’ Patent Rights be developed and utilized to the fullest
extent so that the benefits can be enjoyed by the general public.

The parties agree as follows:

1. DEFINITIONS

     1.1 “Regents’ Patent Rights” means The Regents interest in any of the patent applications
listed in Appendix A attached to this Agreement and assigned to The Regents (UCLA Case Nos.
LA96-517-03/04); any continuing applications thereof including divisions; but excluding
continuations-in-part except to the (extent of claims entitled to the priority date of the parent
case); any patents issuing on these applications including reissues and reexaminations; and any
corresponding foreign patents or patent applications; all of which will be automatically
incorporated in and added to Appendix A and made a part of this Agreement.

     1.2 “Licensed Product” means any article, composition, apparatus, substance, chemical, or any
other material covered by Regents’ Patent Rights or whose manufacture, use or sale would constitute
an infringement of any claim within Regents’ Patent Rights, or any service, article, composition,
apparatus, chemical, substance, or any other material made, used, or sold by or utilizing or
practicing a Licensed Method.

     1.3 “Licensed Method” means any process or method which is covered by Regents’ Patent Rights
or whose use or practice would constitute an infringement of any claim within Regents’ Patent
Rights.

     1.4 “Field” means endovascular embolectomy

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     1.5 “Affiliate” means any corporation or other business entity in which Licensee owns or
controls, directly or indirectly, at least 50% of the outstanding stock or other voting rights
entitled to elect directors. In any country where the local law does not permit foreign equity
participation of at least 50%, then “Affiliate” means any company in which Licensee owns or
controls, directly or indirectly, the maximum percentage of outstanding stock or voting rights that
is permitted by local law. All references to Licensee herein shall be meant to include Affiliates.

     1.6 “First Commercial Sale” means the first sale of any Licensed Product by Licensee or any
Affiliate or Sublicensee, following approval of its marketing by the appropriate governmental
agency for the country in which the sale is to be made. When governmental approval is not
required, “First Commercial Sale” means the first sale in that country.

     1.7 “Net Sales” means the total amount received by Licensee or any Affiliate from the sale or
distribution of Licensed Products less the sum of the following deductions when applicable and
separately invoiced: cash, trade, or quantity discounts; sales, use, tariff, import/export duties
or other excise taxes imposed upon particular sales; transportation charges; and allowances or
credits to customers because of rejections or returns.

     1.8 “Sublicensee” means any third party sublicensed by Licensee to make, have made, use or
sell any Licensed Product or to practice any Licensed Method.

     1.9 “Sublicensing Income” means income received by Licensee under or on account of
Sublicenses. Sublicensing Income includes income received by way of license issue fees, milestone
payments, and the like but specifically excludes royalties on the sale or distribution of Licensed
Products or the practice of Licensed Methods. Not included in the definition of Sublicensing
Income is income received by Licensee as payment or reimbursement for research costs conducted by
or for Licensee, including costs associated with materials, equipment or clinical testing.

2. GRANT

     2.1 The Regents hereby grants to Licensee an exclusive license (the “License”) under Regents’
Patent Rights, in jurisdictions where Regents’ Patent Rights exist, to make, have made, use, sell,
offer to sell, or import Licensed Products and to practice Licensed Methods in the Field.

     2.2 The Regents expressly reserves the right to use Regents’ Patent Rights and associated
technology for educational, research and non-commercial clinical purposes, including sharing
tangible research results with other non-profit institutions for their use of similar scope.

3. SUBLICENSES

     3.1 The Regents also grants to Licensee the right to issue exclusive or nonexclusive
sublicenses (“Sublicenses”) to third parties to make, have made, use and sell Licensed Products and
to practice Licensed Methods in the Field in any jurisdiction in which Licensee has exclusive
rights under this Agreement. All Sublicenses will be subject to the rights of The Regents under
this Agreement.

     3.2 Licensee must pay to The Regents [*]% of all Sublicensing Income.

     3.3 On Net Sales of Licensed Products sold or disposed of by a Sublicensee, Licensee must pay
to The Regents an earned royalty in accordance with Article 5 (Royalties) as if these were

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY
[*], HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

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Licensee’s Net Sales. Any royalties received by Licensee in excess of royalties due to The
Regents under this Paragraph belong to Licensee.

     3.4 Licensee must provide to The Regents a copy of each Sublicense within 30 days of
execution, and a copy of all information submitted to Licensee by Sublicensees relevant to the
computation of the payments due to The Regents under this Article 3.

     3.5 If this Agreement is terminated for any reason, all outstanding Sublicenses will be
assigned by Licensee to The Regents, at the option of The Regents. The Sublicenses will remain in
full force and effect with The Regents as the licensor or sublicensor instead of Licensee, but the
duties of The Regents under the assigned Sublicenses will not be greater than the duties of The
Regents under this Agreement, and the rights of The Regents under the assigned Sublicenses will not
be less than the rights of The Regents under this Agreement, including all financial consideration
and other rights of The Regents.

4. FEES

     4.1 In partial consideration for the License, Licensee will pay to The Regents a license issue
fee of $[*] within 30 days of the Effective Date. This fee is nonrefundable and is not an advance
against royalties.

     4.2 For each Licensed Product reaching the milestones indicated below, Licensee will make the
following payment to The Regents within 30 days of reaching the milestones:

	 	4.2(a) 	 	 Within 30 days of the earlier to occur of (i) receiving a 510(k)
approval from the US Food and Drug Administration (“FDA”) or (ii) the
one year anniversary of the Effective Date, Licensee will pay to The
Regents the sum of $[*].
	 
	 	4.2(b)  	 	 Within 30 days of the third anniversary of the effective date,
Licensee will pay to The Regents the sum of $[*].

     4.3 Licensee must pay to The Regents a license maintenance fee of $[*] beginning on the
one-year anniversary date of the Effective Date of this Agreement and continuing annually on each
anniversary date of the Effective Date. The maintenance fee will not be due and payable on any
anniversary date of the Effective Date if on that date Licensee is commercially selling a Licensed
Product and paying an earned royalty to The Regents on the sales of that Licensed Product. The
license maintenance fees are non-refundable and are not an advance against royalties.

5. ROYALTIES

     5.1 Licensee must pay to The Regents for sale of Licensed Products in the Field by Licensee or
its Affiliates an earned royalty according to the following rates dependent upon the US regulatory
status of the products:

	 	5.1(a)  	 	 If the Licensed Product has not yet been approved for sale in the US
or if it is approved for sale through the 510(k) process as defined by
the FDA without a clinical trial, Licensee shall pay an earned royalty
of [*]% of Net Sales in countries where The Regents hold one or more
issued patents or pending applications contained in The Regents’ Patent
Rights.

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY
[*], HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

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	 	5.1(b)  	 	 If the Licensed Product is approved for sale for at least one
application in the US through a process which requires an IDE clinical
trial leading to a PMA or a 510(k), then Licensee shall pay an earned
royalty of [*]% of Net Sales in countries where The Regents hold one or
more issued patents or pending applications contained in The Regent’s
patent Rights.

     5.2 Licensee must pay to The Regents a minimum annual royalty for the life of Regents’ Patent
Rights, beginning in the year of the First Commercial Sale of Licensed Product. The minimum
royalty for the year of the First Commercial Sale of Licensed Product will be $[*]; the minimum
royalty for the year following the year of the First Commercial Sale of Licensed Product will be
$[*], and the minimum royalty for the third and all subsequent years will be $[*]. For the first
year of commercial sales, Licensee’s obligation to pay minimum annual royalties will be pro-rated
for the number of months remaining in that calendar year when commercial sales commence and will be
due the following February 28. For subsequent years, Licensee must pay the minimum annual royalty
to The Regents by February 28 of each year. The minimum annual royalty will be credited against
the earned royalty due and owing for the calendar year in which the minimum payment was made.

     5.3 Paragraphs 1.1, 1.2, 1.3 and 1.4 define Regents’ Patent Rights, Licensed Products,
Licensed Methods and the Field of use so that royalties are payable on products covered by pending
patent applications and issued patents. Royalties accrue for the duration of this Agreement.

     5.4 Licensee must pay royalties owed to The Regents on a quarterly basis. Licensee must pay
the royalties within two months of the end of the calendar quarter in which the royalties accrued.

     5.5 All monies due The Regents must be paid in United States funds. When Licensed Products
are sold for monies other than United States dollars, the royalties will first be determined in the
foreign currency of the country in which those Licensed Products were sold and, second, converted
into equivalent United States funds. Licensee must use the exchange rate established by the Bank
of America in San Francisco, California on the last day of the calendar quarter.

     5.6 Any tax for the account of The Regents required to be withheld by Licensee under the laws
of any foreign country must be promptly paid by Licensee for and on behalf of The Regents to the
appropriate governmental authority. Licensee will use its best efforts to furnish The Regents with
proof of payment of any tax. Licensee is responsible for all bank transfer charges. All payments
made by Licensee in fulfillment of The Regents’ tax liability in any particular country will be
credited against fees or royalties due The Regents for that country.

     5.7 If at any time legal restrictions prevent the acquisition or prompt remittance of United
States Dollars by Licensee with respect to any country where a Licensed Product is sold, the
Licensee shall pay royalties due to The Regents from Licensee’s other sources of United States
Dollars.

     5.8 If any patent or any claim included in Regents’ Patent Rights is held invalid or
unenforceable in a final decision by a court of competent jurisdiction from which no appeal has or
can be taken, all obligation to pay royalties based on that patent or claim or any claim patentably
indistinct from it will cease as of the date of that final decision. Licensee will not, however,
be relieved from paying any royalties that accrued before that decision or that are based on
another patent or claim not involved in that decision.

     5.9 If Licensee transfers Licensed Products for end-use to itself or an Affiliate or
Sublicensee, that transfer is considered a sale at list price, and Licensee must pay a royalty in
accordance with this

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY
[*], HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

4

 

Article 5 (Royalties). If Licensee sells a Licensed Product to an Affiliate or Sublicensee at
a price lower than that customarily charged to an unrelated third party, the royalties paid to The
Regents will be based on the Net Sales of Licensed Products by the Affiliate or Sublicensee to
their customers.

6. DILIGENCE

     6.1 Upon the execution of this Agreement, Licensee must diligently proceed with the
development, manufacture and sale (“Commercialization”) of Licensed Products and must earnestly and
diligently endeavor to market them within a reasonable time after execution of this Agreement and
in quantities sufficient to meet the market demands for them.

     6.2 Licensee must endeavor to obtain all necessary governmental approvals for the
Commercialization of Licensed Products.

     6.3 The Regents has the right and option to terminate this Agreement following the procedure
described in Article 12 if Licensee fails to perform any of the terms in this Paragraph 6.3. This
right, if exercised by The Regents, supersedes the rights granted in Article 2 (Grant).

	 	6.3(a)  	 	 Licensee shall provide detailed business plan to The Regents by December 1, 1999.
	 
	 	6.3(b)  	 	 Licensee shall submit an IDE by March 2001.
	 
	 	6.3(c)  	 	 Licensee shall obtain IDE approval by the end of 2001.
	 
	 	6.3(d)  	 	 Licensee shall initiate Phase I Clinical Trials by July 2002.
	 
	 	6.3(e)  	 	 Licensee shall submit PMA by the end of 2003.
	 
	 	6.4(f)	 	Licensee shall achieve First Commercial Sale of Licensed Products in the US by
the end of 2004.

     6.4 Licensee has the sole discretion for making all decisions as to how to commercialize any
Licensed Product.

7. PATENT FILING, PROSECUTION AND MAINTENANCE

     7.1 The Regents will file, prosecute and maintain the patents and applications comprising
Regents’ Patent Rights. These patents will be held in the name of The Regents and will be obtained
with counsel of The Regents’ choice. The Regents must provide Licensee with copies of each patent
application, office action, response to office action, request for terminal disclaimer, and request
for reissue or reexamination of any patent or patent application under Regents’ Patent Rights. The
Regents will consider any comments or suggestions by Licensee. The Regents is entitled to take
action to preserve rights and minimize costs whether or not Licensee has commented.

     7.2 Licensee will bear all costs incurred prior to and during the term of this Agreement in
the preparation, filing, prosecution and maintenance of patent applications and patents in Regents’
Patent Rights. Licensee must send payment to The Regents within 30 days of Licensee’s receipt of
an invoice.

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     7.3 Licensee has the right to request patent protection on the Invention in foreign countries
if the rights are available. Licensee must notify The Regents of its decision within eight months
of the filing of the corresponding United States patent application. This notice must be in
writing and must identify the countries desired. The absence of this notice from Licensee to The
Regents will be considered an election not to secure foreign rights.

     7.4 Eight months after the filing of the corresponding United States application, but not
sooner, The Regents will have the right to file patent applications at its own expense in any
country in which Licensee has not identified in written notice provided by 7.3. These applications
and resulting patents will not be subject to this Agreement.

     7.5 Licensee’s obligation to underwrite and to pay all United States and foreign patent costs
will continue for as long as this Agreement remains in effect. Licensee may terminate its
obligations with respect to any given patent application or patent upon three months written notice
to The Regents. The Regents will use its best efforts to curtail patent costs chargeable to
Licensee under this Agreement after this notice is received from Licensee. The Regents may
continue prosecution or maintenance of these application(s) or patent(s) at its sole discretion and
expense, and Licensee will have no further rights or licenses to them.

     7.6 The Regents will use its best efforts to not allow any Regents’ Patent Rights for which
Licensee is licensed and is underwriting the costs of to lapse or become abandoned without
Licensee’s authorization or reasonable notice, except for the filing of continuations, divisionals,
or the like substitute for the lapsed application.

8. PATENT INFRINGEMENT

     8.1 In the event that Licensee learns of the substantial infringement in the Field of any
patent in Regents’ Patent Rights, Licensee will inform The Regents in writing and will provide The
Regents with reasonable evidence of the infringement. During the period and in a jurisdiction
where Licensee has exclusive rights under this Agreement, neither party will notify a third party
of the infringement of any of Regents’ Patent Rights without first obtaining consent of the other
party, which consent must not be unreasonably denied. Both parties will use their best efforts to
cooperate to terminate the infringement without litigation.

     8.2 Licensee may request that The Regents take legal action against the infringement of
Regents’ Patent Rights in the Field. This request must be in writing and must include reasonable
evidence of the infringement and the damages to Licensee. If the infringing activity has not been
abated within 90 days following the effective date of the request, The Regents has the right to (a)
commence suit on its own account or (b) refuse to participate in a suit. The Regents must give
notice of its election in writing to Licensee by the end of the 100th day after receiving notice of
the request from Licensee. Licensee may thereafter bring suit for patent infringement in its own
name if and only if The Regents elected not to commence suit and if the infringement occurred
during the period and in a jurisdiction where the third party had allegedly infringed Licensee’s
exclusive rights under this Agreement. However, in the event Licensee elects to bring suit in
accordance with this Paragraph 8.2, The Regents may thereafter join the suit at its own expense.
Licensee agrees not to bring suit for patent infringement without following the procedures of this
paragraph, and both parties agree to be bound by the outcome of a suit for past patent
infringement.

     8.3 Any legal action will be at the expense of the party that brings the suit and, with the
exception of Paragraph 8.5, all recoveries will belong to that party. Legal action brought jointly
by The

6

 

Regents and Licensee and fully participated in by both, however, will be at the joint expense of
the parties and all recoveries will be shared jointly by them in proportion to the share of expense
paid by each party.

     8.4 Each party must cooperate with the other in litigation proceedings instituted under this
Article but at the expense of the party who brings the suit. The litigation will be controlled by
the party bringing the suit. Where Regents do not join a suit, The Regents may be represented by
counsel of its choice.

     8.5 If Licensee undertakes the enforcement or defense of any Regents’ Patent Rights by
litigation, any recovery of damages by Licensee will be applied first toward Licensee’s
unreimbursed expenses and legal fees relating to the suit. Licensee will retain the balance of the
recovery but will pay The Regents a [*]% royalty on this balance. If Regents should undertake
enforcement or defense the reciprocal will apply.

9. PROGRESS AND ROYALTY REPORTS

     9.1 Beginning January 31, 2000, Licensee must submit to The Regents semiannual progress
reports covering Licensee’s activities related to the development and testing of all Licensed
Products and the obtaining of the governmental approvals necessary for marketing. These progress
reports must be made for each Licensed Product until its First Commercial Sale.

     9.2
The progress reports submitted under Paragraph 9.1 must include the following topics:

9.2(a)       a summary of work completed;

9.2(b)       key scientific discoveries;

9.2(c)       a summary of work in progress;

9.2(d)      a current schedule of anticipated events or milestones;

9.2(e)       market plans for introduction of Licensed Products; and

9.2(f)       a summary of resources (dollar value) spent in the reporting period.

     9.3 Licensee must notify The Regents if Licensee or any of its Sublicensees or Affiliates
ceases to be a small entity (as defined by the United States Patent and Trademark Office) under the
provisions of 35 U.S.C. §41(h).

     9.4 Licensee must report the date of the First Commercial Sale in the royalty report
immediately following that Sale.

     9.5 After the First Commercial Sale of each Licensed Product, Licensee must make quarterly
royalty reports to The Regents by February 28, May 31, August 31 and November 30 of each year
(i.e., within two months from the end of each calendar quarter). Each royalty report must cover
Licensee’s most recently completed calendar quarter and must show:

9.5(a)     gross sales and Net Sales of any Licensed Product;

9.5(b)     number of each type of Licensed Product sold;

9.5(c)     royalties payable to The Regents.

     9.6 Licensee must state in its royalty report if it had no sales of any Licensed Product.

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY
[*], HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

7

 

10. BOOKS AND RECORDS

     10.1 Licensee must keep accurate books and records of all Licensed Products manufactured, used
or sold. Licensee must preserve these books and records for at least five years from the date of
the royalty payment to which they pertain.

     10.2 The Regents’ representatives or agents are entitled to inspect these books and records at
reasonable times. The Regents will pay the fees and expenses of these inspections. If an error
favoring Licensee of more than [*]% of the total annual royalties is discovered, then Licensee will
pay the fees and expenses of these inspections.

11. LIFE OF THE AGREEMENT

     11.1 Unless otherwise terminated by operation of law or by acts of the parties in accordance
with the terms of this Agreement, this Agreement is in force from the Effective Date recited on
page one and remains in effect for the life of the last-to-expire patent in Regents’ Patent Rights,
or until the last patent application licensed under this Agreement is abandoned and no patent in
Regents’ Patent Rights ever issues.

     11.2 Upon termination of this Agreement, Licensee will have no further right to make, have
made, use, sell, offer to sell, or import any Licensed Product except as provided in Article 14
(Disposition of Licensed Products on Hand Upon Termination).

     11.3 Any expiration or termination of this Agreement will not affect the rights and
obligations set forth in the following Articles:

     Article 10 Books and Records

     Article 14 Disposition of Licensed Products on Hand upon Termination

     Article 16 Use of Names and Trademarks and Nondisclosure of Agreement

     Article 17 Limited Warranty

     Article 18 Indemnification

12. TERMINATION BY THE REGENTS

     12.1 If Licensee violates or fails to perform any material term or covenant of this Agreement,
including diligence requirements as described in Article 6, then The Regents may give written
notice of the default (“Notice of Default”) to Licensee. If Licensee does not repair the default
within 90 days after the effective date of the Notice of Default, then The Regents has the right to
terminate this Agreement and the License by a second written notice (“Notice of Termination”) to
Licensee. If The Regents sends a Notice of Termination to Licensee, then this Agreement
automatically terminates on the effective date of this notice. Termination does not relieve
Licensee of its obligation to pay any royalty or fees owing at the time of termination and does not
impair any accrued right of The Regents.

13. TERMINATION BY LICENSEE

     13.1 Licensee has the right at any time to terminate this Agreement in whole or with respect
to any portion of Regents’ Patent Rights by giving written notice to The Regents. This notice of
termination will be subject to Article 19 (Notices) and will be effective 90 days after the
effective date of the notice.

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY
[*], HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

8

 

     13.2 Any termination in accordance with Paragraph 13.1 does not relieve Licensee of any
obligation or liability accrued prior to termination. Nor does termination rescind anything done by
Licensee or any payments made to The Regents prior to the effective date of termination.
Termination does not affect in any manner any rights of The Regents arising under this Agreement
prior to termination.

14. DISPOSITION OF LICENSED PRODUCTS ON HAND UPON TERMINATION

     14.1 Upon termination of this Agreement, Licensee will have the right to dispose of all
previously made or partially made Licensed Products, but no more, within a period of six months.
But Licensee must submit royalty reports on the sale of these Licensed Products and must pay
royalties at the rate and at the time provided in this Agreement.

15. PATENT MARKING

     15.1 Licensee must mark all Licensed Products made, used or sold under the terms of this
Agreement, or their containers, in accordance with the applicable patent marking laws.

16. USE OF NAMES AND TRADEMARKS AND NONDISCLOSURE OF AGREEMENT

     16.1 Neither party is permitted to use any name, trade name, trademark or other designation of
the other party or its employees (including contraction, abbreviation or simulation of any of the
foregoing) in advertising, publicity or other promotional activity. Unless required by law,
Licensee is expressly prohibited from using the name “The Regents of the University of California”
or the name of any campus of the University of California.

     16.2 Neither party is permitted to use or refer to this Agreement or any license granted
hereunder in any promotional activity without the express written approval of the other party.
However, The Regents shall be free to release to the inventors of the Invention covered by this
Agreement and senior administration officials employed by The Regents the terms and conditions of
this Agreement upon their request. If such release is made, The Regents shall request that the
recipients not disclose such terms and conditions to others. It is further understood that should
a third party inquire whether a license is available, The Regents may disclose the existence of
this Agreement and the extent of the grant in Article 2 (Grant) to such third party, but shall not
disclose the name of the Licensee, except where The Regents is required to release information
under either the California Public Records Act or other applicable law.

17. LIMITED WARRANTY

     17.1 The Regents warrants that it has the lawful right to grant this license to Licensee.

     17.2 This License and the associated Invention are provided WITHOUT WARRANTY OF
MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE OR ANY OTHER WARRANTY, EXPRESS OR IMPLIED. THE
REGENTS MAKES NO REPRESENTATION OR WARRANTY THAT ANY LICENSED PRODUCT WILL NOT INFRINGE ANY PATENT
OR OTHER PROPRIETARY RIGHT.

     17.3 IN NO EVENT WILL THE REGENTS BE LIABLE FOR ANY INCIDENTAL, SPECIAL OR CONSEQUENTIAL
DAMAGES RESULTING FROM EXERCISE OF THIS LICENSE OR THE USE OF THE INVENTION OR LICENSED PRODUCTS OR
THE USE OR THE PRACTICE OF LICENSED METHODS.

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   17.4 Nothing in this Agreement will be construed as:

	 	17.4(a)  	 	 a warranty or representation by The Regents as to the validity or scope of
any of Regents’ Patent Rights;
	 
	 	17.4(b)  	 	 a warranty or representation that anything made, used, sold or otherwise
disposed of under any license granted in this Agreement is or will be free from
infringement of patents of third parties;
	 
	 	17.4(c)  	 	 an obligation to bring or prosecute actions or suits against third parties
for patent infringement except as provided in Article 8 (Patent Infringement);
	 
	 	17.4(d)  	 	 conferring by implication, estoppel or otherwise any license or rights under
any patents of The Regents other than Regents’ Patent Rights as defined herein,
regardless of whether such patents are dominant or subordinate to Regents’
Patent Rights; or
	 
	 	17.4(e)  	 	 an obligation to furnish any know-how not provided in Regents’ Patent Rights.

18. INDEMNIFICATION

     18.1 Licensee must indemnify, hold harmless and defend The Regents, its officers, employees,
and agents, the sponsors of the research that led to the invention, the inventors of the patents
and patent applications in Regents’ Patent Rights and their respective employers from and against
any and all liability, claims, suits, losses, damages, costs, fees and expenses resulting from or
arising out of exercise of this license or any sublicense.

     18.2 Licensee, at its sole cost and expense, must insure its activities in connection with the
work under this Agreement and obtain, keep in force and maintain Comprehensive or Commercial Form
General Liability Insurance (contractual liability included) with limits as follows:

	 	 	 	 	 	 	 	 	 
	 	18.2	(a)	 	Each occurrence
	 	$	1,000,000.	 
	 	18.2	(b)	 	Products/completed operations aggregate
	 	$	5,000,000.	 
	 	18.2	(c)	 	Personal and advertising injury
	 	$	1,000,000.	 
	 	18.2	(d)	 	General aggregate (commercial form only)
	 	$	5,000,000.	 

     Licensee shall obtain liability insurance prior to use of Licensed Products in
humans.

     18.3 Licensee expressly understands, however, that the coverages and limits in Paragraph 18.2
do not in any way limit the Licensee’s liability. Licensee must furnish The Regents with
certificates of insurance evidencing compliance with all requirements. Licensee’s insurance must:

	 	18.3(a)  	 	provide for 30-day advance written notice to The Regents of any modification;
	 
	 	18.3(b)  	 	indicate that The Regents of the University of California is endorsed as an
Insured under the coverages listed in Paragraph 18.2; and
	 
	 	18.3(c)  	 	include a provision that the coverages will be primary and will not
participate with nor will be excess over any valid and collective insurance or
program of self-insurance carried or maintained by The Regents.

10

 

19. NOTICES

     19.1 Any notice or payment required to be given to either party must be sent to the respective
address given below and is effective: (a) on the date of delivery if delivered in person, (b) five
days after mailing if mailed by first-class certified mail, postage paid, or (c) on the next
business day if sent by overnight delivery. Either party may change its designated address by
written notice.

	 	 	 
	For Licensee:

	 	FOUNDRY, LLC
	 

	 	604-D Fifth Ave.
	 

	 	Redwood City, CA 94063
	 

	 	Attention: Martin Dieck
	 
	 	 
	For The Regents:

	 	The Regents of the University of California
	 

	 	University of California, Los Angeles
	 

	 	Office of Sponsored Research
	 

	 	10945 Le Conte Avenue, Suite 1401
	 

	 	Box 951406
	 

	 	Los Angeles, California 90095-1406
	 
	 	 
	 

	 	Attention: Director

20. ASSIGNABILITY

     20.1 This Agreement is binding upon and inures to the benefit of The Regents, its successors
and assigns, but is personal to Licensee and assignable by Licensee only with the written consent
of The Regents.

21. LATE PAYMENTS

     21.1 For each royalty payment or fee not received by The Regents when due, Licensee must pay
to The Regents a simple interest charge of [*]% per annum to be calculated from the date payment
was due until it was actually received by The Regents.

22. WAIVER

     22.1 The waiver of any breach of any term of this Agreement does not waive any other breach of
that or any other term.

23. GOVERNING LAWS

     23.1 THIS AGREEMENT IS TO BE INTERPRETED AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE
STATE OF CALIFORNIA, without respect to any choice of law rules which direct the application of the
laws of a jurisdiction other than California, but the scope and validity of any patent or patent
application will be governed by the applicable laws of the country of the patent or patent
application.

24. GOVERNMENT APPROVAL OR REGISTRATION

     24.1 If this Agreement or any associated transaction is required by the law of any nation to
be either approved or registered with any governmental agency, Licensee will assume all legal
obligations.

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY
[*], HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

11

 

to do so. Licensee will notify The Regents if it becomes aware that this Agreement is subject
to a United States or foreign government reporting or approval requirement. Licensee will make all
necessary filings and pay all costs including fees, penalties, and all other out-of-pocket costs
associated with such reporting or approval process.

25. EXPORT CONTROL LAWS

     25.1 Licensee must observe all applicable United States and foreign laws with respect to the
transfer of Licensed Products and related technical data to foreign countries, including the
International Traffic in Arms Regulations (ITAR) and the Export Administration Regulations.

26. FORCE MAJEURE

     26.1 The parties will be excused from any performance required under this Agreement if
performance is impossible or unfeasible due to any catastrophe or other major event beyond their
reasonable control, including war, riot, or insurrection; laws, proclamations, edicts, ordinances
or regulations; strikes, lockouts or other serious labor disputes; and floods, fires, explosions,
or other natural disasters. When such events abate, the parties’ respective obligations will
resume. A suspension of duty under this Agreement due to force majeure shall not be for a period of
more than one year.

27. CONFIDENTIALITY

   27.1 If The Regents discloses confidential information to Licensee, The Regents will designate
this information as confidential by appropriate legend or instruction, and Licensee will:

	 	27.1(a)	 	 use the same degree of care to maintain the secrecy of the
confidential information as it uses to maintain the secrecy of its own
information of like kind; and
	 
	 	27.1(b)	 	 use the confidential information only to accomplish the
purposes of this Agreement.

   
27.2 Licensee will not disclose confidential information received from The Regents except to
its employees, customers, distributors and other agents who are bound to it by similar obligations
of confidence and only as required to accomplish the purposes of this Agreement.

     27.3 Licensee will not have any confidentiality obligation with respect to the confidential
information belonging to or disclosed by The Regents that:

	 	27.3(a) 	 	 the receiving party can demonstrate by written records was previously known
to it;
	 
	 	27.3(b)	 	the receiving party lawfully obtained from sources under no obligation of
confidentiality; or
	 
	 	27.3(c)  	 	 is or becomes publicly available other than through an act or omission of the
receiving party or any of its employees.

   
27.4 The provisions of this Article 27 will continue in effect for five years after expiration
or termination of this Agreement.

12

 

28. MISCELLANEOUS

     28.1 The headings of the several sections are inserted for convenience of reference only and
are not intended to be a part of, or to affect the meaning or interpretation of, this Agreement.

     28.2 This Agreement is not binding upon the parties until it has been signed below on behalf
of each party, in which event it becomes effective as of the date recited on page one.

     28.3 No amendment or modification of this Agreement will be valid or binding upon the parties
unless made in writing and signed by each party.

     28.4 This Agreement embodies the entire understanding of the parties and supersedes all
previous communications, representations or understandings, either oral or written, between the
parties relating to the subject matter hereof, except for the Secrecy Agreement dated August 13,
1999, which continues to the extent it is not inconsistent with this Agreement.

     28.5 If any part of this Agreement is for any reason found to be unenforceable, all other
parts nevertheless remain enforceable as long as a party’s rights under this Agreement are not
materially affected. In lieu of the unenforceable provision, the parties will substitute or add as
part of this Agreement a provision that will be as similar as possible in economic and business
objectives as was intended by the unenforceable provision.

     28.6 None of the provisions of this Agreement are intended to create any form of joint venture
between the parties, rights to third parties, or rights that are enforceable by any third party.

Both The Regents and Licensee have executed this Agreement in duplicate originals by their
authorized officers on the dates written below:

	 	 	 	 	 	 	 	 	 	 	 
	THE FOUNDRY, LLC	 	 	 	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	By

	 	/s/ Allan R. Will
	 	 	 	By
	 	/s/ Patricia Brennan	 	 
	 

	 	 
	 	 	 	 	 	 	 	 
	 

	 	Signature
	 	 	 	 	 	Signature	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Name Allan R. Will	 	 	 	Name Patricia Brennan	 	 
	Title Chairman	 	 	 	Title Director	 	 
	Date 11-29-99	 	 	 	Date 11/24/99	 	 

13

 

APPENDIX A

REGENTS’ PATENT RIGHTS

United States Patent No 5,895,398 entitled “Method of Using a Clot Capture Coil,” issued April 20,
1999.

United States Patent Serial Number 09/170,135 filed 10/12/98, entitled “Clot Capture Coil”

14

 

First Amendment

To

License Agreement No. 2000-04-0291

     This Amendment is made and is effective this 28 day of June, 2000 by and between The Regents
of the University of California (“The Regents”), a California corporation having its corporate
offices located at 1111 Franklin Street, Oakland, California 94607-5200, acting through its offices
located at 10920 Wilshire Blvd., Suite 1200, Los Angeles, California 90024-1406 and Concentric
Medical, Inc. having offices at 2585 Leghorn St., Mountain View, CA 94043; and amends License
Agreement No. 2000-04-0291 between The Foundry and The Regents, effective November 29, 1999, which
License Agreement was subsequently assigned by The Foundry to Concentric Medical by letter dated
January 4, 2000.

     WHEREAS, under License Agreement No. 2000-04-0291 The Regents licensed the United States
patent rights encompassed in United States Patent No. 5,895,398 entitled “Method of Using a Clot
Capture Coil” issued April 20, 1999; United States Patent Serial Number 09/170,135 filed October
12, 1998; and certain related applications;

     WHEREAS, The Regents released to the inventors, Drs. Yves Pierre Gobin and Jeffrey Wensel, the
foreign rights to the Clot Capture Coil encompassed in PCT/US97/01807 on July 8, 1998;

     WHEREAS, under the terms of the release, the inventors agreed to the standard terms and
conditions of a release of patent rights by The Regents, one of which prohibits all future research
at UCLA on the released invention;

     WHEREAS, Drs. Gobin and Wensel assigned their foreign patent rights to Concentric Medical;

     WHEREAS, Dr. Gobin wishes to commence research on the released invention at UCLA;

     WHEREAS, Concentric Medical wishes to reassign to The Regents the patent rights to the
released invention which it obtained from Drs. Gobin and Wensel (“Reassigned Rights”);

     WHEREAS, Concentric Medical wishes to license these Reassigned Rights from The Regents under
an amended License Agreement No. 2000-04-0291; and

     WHEREAS, The Regents in consideration for the reassignment of the patent rights and hence a
considerably larger market for the licensed products will reduce the royalty rate under Paragraph
5.1(a) of the License Agreement, and will permit research related to the Reassigned Rights to be
conducted at UCLA.

     The parties agree as follows:

1. Paragraph 5.1(a) of License Agreement No. 2000-04-0291 shall be replaced with the following:

     5.1 (a) If the Licensed Product has not yet been approved for sale in the US or if it is
approved for sale through the 501(k) process as defined by the FDA without a clinical trial,
Licensee shall pay an earned royalty of [*]% of Net Sales in countries where The Regents hold one
or more issued patents or pending applications contained in The Regents’ Patent Rights.

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY
[*], HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

 

 

     2. Paragraph 5.1(b) of License Agreement No. 2000-04-0291 shall be replaced with the
following:

          5.l(b) If the Licensed Product is approved for sale for at least one application in the US
through a process which requires an IDE clinical trial leading to a PMA or a 510(k), then Licensee
shall pay an earned royalty of [*]% of Net Sales in countries where The Regents hold one or more
issued patents or pending applications contained in The Regent’s patent Rights.

     3. Upon execution of this Amendment and subject to the terms and conditions of License
Agreement No. 2000-04-0291 as amended herein, Concentric Medical will and hereby does assign to The
Regents Concentric Medical’s entire right, title and interest in and to the Reassigned Rights. The
Regents hereby acknowledge and agree that the continuing obligations of Drs. Gobin and Wensel, and
of Concentric Medical pursuant to the assignment of such Reassigned Rights to Concentric Medical by
Drs. Gobin and Wensel, shall be of no further force and effect. Without limiting the foregoing
sentence, The Regents hereby acknowledge and agree that the restriction under the terms of the July
8, 1998 UCLA release agreement on further research at UCLA relating to the technology covered by
the Reassigned Rights shall be of no further force and effect.

     4. Concentric Medical hereby represents and warrants that as of the effective date of this
Amendment, it is the sole owner of all right, title, and interest in and to the Reassigned Rights
and has all rights necessary to assign the Reassigned Rights to The Regents as provided for herein.

     5. Amend Paragraph 1.1 as follows: After “foreign patents or patent applications;” and before
“all of which will be automatically incorporated”, insert “the Reassigned Rights, including without
limitation the foreign patent applications listed on Appendix A;”.

     6. Add to Appendix A:

          PCT/US97/01807, entitled Clot Capture Coil and filed January 31, 1997.

     All other terms and conditions remain the same.

	 	 	 	 	 	 	 	 	 	 	 
	CONCENTRIC MEDICAL, INC.	 	 	 	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	By:

	 	/s/ Martin Dieck
	 	 	 	By:
	 	/s/ Emily Waldron	 	 
	 

	 	 
	 	 	 	 	 	 	 	 
	 

	 	Signature
	 	 	 	 	 	Signature	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Name: Martin Dieck	 	 	 	Name: Emily Waldron	 	 
	Title: President and
CEO	 	 	 	Title: Sr. Technology Transfer Officer	 	 
	Date: 7/1/00	 	 	 	Date: 6.28.00	 	 

CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY
[*], HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE
COMMISSION PURSUANT TO RULE 406 OF THE SECURITIES ACT OF 1933, AS AMENDED.

2

 

			
	 	 	 
	1380 Shorebird Way Mountain View, CA 94043	 	 
	tel: 650.938.2100 fax: 650.938.2700 www.concentric-medical.com
	 	Concentric Medical

July 27, 2004

Via Federal Express

The Regents of the University of California

University of California, Los Angeles

Office of Sponsored Research

10945 Le Conte Avenue, Suite 1401

Box 951406

Los Angeles, CA 90095-1406

Attention: Director

	 	 	 
	Subject:

	 	Concentric Medical’s License of Wensel/Gobin Patents
	Case No:

	 	LA96-517-03/04
	Re:

	 	Termination of Patents Rights other than US and Europe

Dear Director:

Pursuant to section 13.1 of the license agreement between UC and Concentric Medical, Concentric
Medical hereby notifies UC that Concentric Medical terminates this Agreement with respect to all of
the Regent’s Patent Rights except US and European rights. Concentric acknowledges that termination
of all rights outside the US and Europe shall be effective 90 days from the effective date of this
notice.

Concentric Medical acknowledges that the license shall remain in force for the Regent’s Patents
Rights in the United States and Europe.

Please also note, Concentric’s updated address for notification purposes as:

Concentric Medical

Attn: Mr. Gary Curtis

1380 Shorebird Way

Mountain View, CA 94043

Sincerely,

/s/ Gary Curtis

Gary Curtis

President & CEO

			
	Cc:	 	Jens Hoekendijk, Hoekendijk & Lynch, LLP

File

 

 

FOURTH AMENDMENT TO EXCLUSIVE LICENSE AGREEMENT

UC Agreement Control No. 2000-04-0291

     This Fourth Amendment to Exclusive License Agreement (this “Amendment”), dated as of July 10,
2006, is made by and among The Regents of the University of California, a California corporation
(“The Regents”), and Concentric Medical (“Licensee”).

     WHEREAS, The Regents and Concentric Medical are parties to an Exclusive License Agreement,
dated as of November 29, 1999 (the “Exclusive License Agreement”);

     WHEREAS, the parties mutually intend to enter into this Fourth Amendment to amend the terms of
the Exclusive License Agreement, as specified below;

     WHEREAS, Licensee requested on July 27, 2004 to drop rights under Paragraph 7.5 in Japan and
Canada and The Regents continued independent prosecution;

     WHEREAS, Licensee now wishes to include Japanese and Canadian patent rights back into the
definition of Regents’ Patent Rights under Paragraph 1.1;

     THEREFORE, the parties hereby agree as follows:

     1. Paragraph 1.1 (“Regents Patent Rights”) is deleted and replaced with the following, which
is amended as follows to include foreign patents and application filings:

          1.1 “Regents’ Patent Rights” means The Regents interest in any of the patent applications
listed in Appendix A attached to this Agreement and assigned to The Regents (UCLA Case Nos.
1996-517-3, 4); any continuing applications thereof including divisions; but excluding
continuations-in-part except to the extent of claims entitled to the priority date of the parent
case; any patents issuing on these applications including reissues and reexaminations; and any
corresponding foreign patents or patent applications; all of which will be automatically
incorporated in and added to Appendix A and made a part of this Agreement.

     2. Appendix A (Regents’ Patent Rights) is hereby deleted and replaced with the Appendix A
attached to this Fourth Amendment, which is amended to include the foreign patents and application
filings under UCLA Case No. 1996-517-3.

     3. Pursuant to Paragraph 7.2, Licensee will, within thirty (30) days of execution of this
Amendment, reimburse The Regents for past unreimbursed patent expenses for Japanese and Canadian
rights since the prior termination on July 27, 2004.

Page 1 of 3

 

     4. Except for the amendment specifically referenced above, all other terms of the Exclusive
License Agreement shall remain unchanged and in full force and effect.

     The Regents and Concentric Medical have executed this Amendment in duplicate originals by
their authorized officers on the dates written below:

	 	 	 	 	 	 	 	 	 	 	 
	CONCENTRIC MEDICAL	 	 	 	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	By:

	 	/s/ Gary Curtis
	 	 	 	By:
	 	/s/ Emily W. Loughran	 	 
	 

	 	 
	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Name: Gary Curtis	 	 	 	Name: Emily W. Loughran	 	 
	Title: President, CEO	 	 	 	Title: Director of Licensing	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Date: July 17, 2006	 	 	 	Date: July 10, 2006	 	 

Page 2 of 3

 

APPENDIX A

REGENTS’ PATENT RIGHTS

UCLA Case Number 1996-517-3

U.S. Patent Number 5,895,398

Title: Method of Using a Clot Capture Coil

Issued Date: April 20, 1999

Inventors: Jeffrey P. Wensel and Yves P. Gobin

Assigned to The Regents of the University of California

PCT Application Number PCT/US97/01807 ABANDONED in favor of:

Australia Patent Number 733395 issued August 23, 2001 (parent case)

Australia Patent Application Number 200304826 filed June 20, 2003 (2nd Divisional of parent case)

Australia Patent Number 758524 issued July 3, 2003 (1st Divisional of parent case)

Canada Patent Serial Number 2248226 filed on January 31, 1997

Israel Patent Application Number 125612 filed on January 31, 1997

Japan Patent Application Number 9-527922 filed on January 31, 1997

EPO Patent Application Number 06000195.5 (Divisional of parent case) filed on January 31, 1997.

EPO Patent Number 0880341 issued January 11, 2006 ABANDONED in favor of the following countries:
Austria, Belgium, Switzerland, Germany, Denmark, Spain, France, United
Kingdom, Ireland, Italy, Netherlands and Sweden.

UCLA Case Number 1996-517-4

U.S. Patent Number 6,530,935

Title: Clot Capture Coil

Issued Date: March 11, 2003

Inventors: Jeffrey P. Wensel and Yves P. Gobin

Assigned to The Regents of the University of California

Page 3 of 3

 

FIFTH AMENDMENT TO EXCLUSIVE LICENSE AGREEMENT

UC Agreement Control No. 2000-04-0291

     This Fifth Amendment to Exclusive License Agreement (this “Amendment”), dated as of July 19,
2006, is made by and between The Regents of the University of California, a California corporation
(“The Regents”), and Concentric Medical (“Licensee”).

     WHEREAS, The Regents and Concentric Medical are parties to an Exclusive License Agreement,
dated as of November 29, 1999 (the “Exclusive License Agreement”);

     WHEREAS, the parties mutually intend to enter into this Fifth Amendment to amend the terms of
the Exclusive License Agreement, as specified below;

     WHEREAS, Licensee requested on July 27, 2004 to drop rights under Paragraph 7.5 in Australia
and Israel and The Regents continued independent prosecution;

     WHEREAS, Licensee now wishes to include Australia and Israel patent rights back into the
definition of Regents’ Patent Rights under Paragraph 1.1;

     THEREFORE, the parties hereby agree as follows:

	 	1.	 	Paragraph 1.1 (“Regents Patent Rights”) is deleted and replaced with the
following, which is amended as follows to include foreign patents and application
filings:

	 	1.1	 	“Regents’ Patent Rights” means The Regents interest in any of the
patent applications listed in Appendix A attached to this Agreement and assigned
to The Regents (UCLA Case Nos. 1996-517-3, 4); any continuing applications
thereof including divisions; but excluding continuations-in-part except to the
extent of claims entitled to the priority date of the parent case; any patents
issuing on these applications including reissues and reexaminations; and any
corresponding foreign patents or patent applications; all of which will be
automatically incorporated in and added to Appendix A and made a part of this
Agreement.

     2. Appendix A (Regents’ Patent Rights) is hereby deleted and replaced with the Appendix A
attached to this Fifth Amendment, which is amended to include the foreign patents and application
filings under UCLA Case No. 1996-517-3.

     3. Pursuant to Paragraph 7.2, Licensee will, within thirty (30) days of execution of this
Amendment, reimburse The Regents for past unreimbursed patent expenses for Australian and Israel
rights since the prior termination on July 27, 2004.

Page 1 of 3

 

     4. Except for the amendment specifically referenced above, all other terms of the Exclusive
License Agreement shall remain unchanged and in full force and effect.

     The Regents and Concentric Medical have executed this Amendment in duplicate originals by
their authorized officers on the dates written below:

	 	 	 	 	 	 	 	 	 	 	 
	CONCENTRIC MEDICAL	 	 	 	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	By:

	 	/s/ Gary Curtis
	 	 	 	By:
	 	/s/ Emily W. Loughran	 	 
	 

	 	 
	 	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Name: Gary Curtis	 	 	 	Name: Emily W. Loughran	 	 
	Title:	 	 	 	Title: Director of Licensing	 	 
	 
	 	 	 	 	 	 	 	 	 	 
	Date: July 21, 2006	 	 	 	Date: July 19, 2006	 	 

Page 2 of 3

 

APPENDIX A

REGENTS’ PATENT RIGHTS

UCLA Case Number 1996-517-3

U.S. Patent Number 5,895,398

Title: Method of Using a Clot Capture Coil

Issued Date: April 20, 1999

Inventors: Jeffrey P. Wensel and Yves P. Gobin

Assigned to The Regents of the University of California

PCT Application Number PCT/US97/01807 ABANDONED in favor of:

Australia Patent Number 733395 issued August 23, 2001 (parent case)

Australia Patent Application Number 200304826 filed June 20, 2003 (2nd Divisional of parent case)

Australia Patent Number 758524 issued July 3, 2003 (1st Divisional of parent case)

Canada Patent Serial Number 2248226 filed on January 31, 1997

Israel Patent Application Number 125612 filed on January 31, 1997

Japan Patent Application Number 9-527922 filed on January 31, 1997

EPO Patent Application Number 06000195.5 (Divisional of parent case) filed on January 31, 1997.

EPO Patent Number 0880341 issued January 11, 2006 ABANDONED in favor of the following countries:

Austria, Belgium, Switzerland, Germany, Denmark, Spain, France, United Kingdom, Ireland, Italy,
Netherlands and Sweden.

UCLA Case Number 1996-517-4

U.S. Patent Number 6,530,935

Title: Clot Capture Coil

Issued Date: March 11, 2003

Inventors: Jeffrey P. Wensel and Yves P. Gobin

Assigned to The Regents of the University of California

Page 3 of 3

 

OFFICE OF INTELLECTUAL PROPERTY ADMINISTRATION

10920 WILSHIRE BOULEVARD, SUITE 1200

LOS ANGELES, CALIFORNIA 90024-1406

PHONE: (310) 794-0558 FAX: (310) 794-0638

ON-CAMPUS MAILCODE: 140648

www.research.ucla.edu/oipa

March 01, 2007

Via Electronic Mail

(kmassa@concentric-medical.com)

Kathy Massa

CONCENTRIC MEDICAL, INC.

1380 Shorebird Way

Mountain View, CA 94043

			
	Re:	 	Revisions to Exclusive License Agreement

UC Agreement Control No. 2000-04-0291

UCLA Case Nos. 1996-517-3 and 1996-517-4

Dear Kathy,

Thank you for your inquiry regarding the “missing” Second and Third Amendments for the above
referenced Agreement. After a thorough review of Concentric Medical, Inc.’s license agreement
file, I can report that (1) all the changes over the life of the Agreement have been documented and
accounted for and (2) amendments entitled “Second Amendment” and “Third Amendment” were never
written and occurred as a document naming error.

It is unclear how the above situation occurred but here is some background. Our office has an
internal naming convention to keep track of agreement revisions that is alphabetical i.e. A, B, C,
etc. However, oftentimes amendments are written and they are entitled numerically such as First,
Second, Third, etc. In the case of Concentric Medical Inc.’s Agreement, there was an error in
nomenclature and the Second and Third Amendments were skipped when the Fourth Amendment was
written.

To prevent further confusion, please refer to the amendments/revisions of the Agreement by their
alphabetical naming convention. All amendments/revisions are attached and labeled for your
reference and convenience. Below is an outline and summary of all amendments/revisions.

 

 

	 	 	 	 	 
	Revision	 	Effective Date	 	Description of Revision Made
	A

	 	01/04/2000
	 	The Foundry grants assignment of US
Patent 5,895,398 to Concentric Medical.
	B

	 	06/28/2000
	 	“First Amendment”
	C

	 	07/06/2001
	 	UCLA Case No. 1996-517-5 added to Agreement
	D

	 	10/08/2001
	 	UCLA Case No. 1996-517-6 added to Agreement
	E

	 	09/10/2002
	 	UCLA Case No. 1996-517-9 added to Agreement
	F

	 	10/27/2004
	 	Filings for Australia, Canada, Israel and Japan dropped. US and EPO filings remain continue unchanged.
	G

	 	07/10/2006
	 	“Fourth Amendment”
	H

	 	07/19/2006
	 	“Fifth Amendment”

Should you have any additional questions regarding this matter, please feel free to contact me.

Sincerely,

/s/ Jane

Jane San

Tech Transfer Specialist

UCLA Office of Intellectual Property Administration

10920 Wilshire Blvd. Ste 1200

Los Angeles, CA 90024-1406

310-794-0378 310-794-0638 (Fax)

			
	Attachments
cc:	 	
Rita Hao

Catherine Lindorfer

Emily W. Loughran

Bernie McCafferty

 -2-exv10w9

 

Exhibit 10.9

ASSIGNMENT AND ASSUMPTION AGREEMENT

     This
Assignment and Assumption Agreement (this “Agreement”), effective as of
January 4, 2000 (the “Effective Date”), is made between The Foundry, LLC
(“Assignor”), and Concentric Medical, Inc., a Delaware corporation (“Assignee”).

RECITALS

     A. Assignor and The Regents of the University of California, a California
corporation (“The Regents”), have entered into an Exclusive License Agreement dated
November 29, 1999, as amended (the “License Agreement”).

     B. Assignor desires to assign its rights and obligations under the License
Agreement to Assignee, and Assignee desires to accept such assignment, on the terms
and conditions set forth herein.

AGREEMENT

     Now, therefore, for good and valuable consideration, the receipt and sufficiency
of which are hereby acknowledged, the parties agree as follows:

     1. Effective as of the Effective Date, Assignor hereby assigns, transfers and
conveys to Assignee, and Assignee hereby accepts, all of Assignor’s right, benefit,
title and interest under the License Agreement.

     2. Effective as of the Effective Date, Assignee accepts the foregoing
assignment and assumes and agrees to keep, perform and fulfill, as a direct
obligation to The Regents, all of the terms, covenants, conditions and obligations required to be
kept, performed and fulfilled by the Assignor under the License Agreement from and after
the Effective Date (the “Assumed Obligations”). For the avoidance of doubt, the
parties agree and acknowledge that the Assumed Obligations shall not include any liability
under the License Agreement arising out of or relating to a breach thereof that occurred
prior to the Effective Date.

     3. This Agreement will be governed by and construed under the laws of the
State of California without regard to conflicts-of-laws principles that would
require the application of any other law.

     4. This Agreement may be executed in any number of counterparts, all of
which together shall constitute one instrument. This Agreement may be executed and
delivered via facsimile.

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     Each of the parties has caused this Agreement to be duly executed on its behalf
effective as of the Effective Date.

	 	 	 	 	 
	 	 	ASSIGNOR:
	 
	 	 	 	 
	 	 	THE FOUNDRY, LLC
	 
	 	 	 	 
	 

	 	By:
	 	/s/ Hanson S. Gifford
	 

	 	 	 	 
	 

	 	Name:
	 	Hanson S. Gifford
	 

	 	Title:
	 	President
	 

	 	Date:	 	 
	 

	 	 	 	 
	 
	 	 	 	 
	 	 	ASSIGNEE:
	 
	 	 	 	 
	 	 	CONCENTRIC MEDICAL, INC.
	 
	 	 	 	 
	 

	 	By:
	 	/s/ Andrew Chmyz
	 

	 	 	 	 
	 

	 	Name:
	 	Andrew Chmyz
	 

	 	Title:
	 	CFO
	 

	 	Date:	 	 
	 

	 	 	 	 

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