Document:

exv10w1

K12
INC.

AMENDMENT TO AMENDED AND RESTATED STOCK OPTION AGREEMENT

     This Amendment (the “Amendment”) to that certain Amended and Restated Stock Option
Agreement between K12 Inc., a Delaware corporation (the “Company”), and Ronald J. Packard
(the “Optionee”) dated as of July 12, 2007 (the “Restated Stock Option Agreement”)
is made effective as of December 23, 2010 (the “Amendment Effective Date”). Except as set
forth in this Amendment, capitalized terms used but not defined herein shall have the meanings
ascribed to them in the Restated Stock Option Agreement.

WITNESSETH

          WHEREAS, the Company and the Optionee previously entered into a Stock Option Agreement, dated
as of July 27, 2006 (the “Original Option Agreement”), pursuant to which the Optionee was
granted certain Options, including Options to purchase up to 1,500,000 shares of Stock at a
per-share option exercise price of Six Dollars ($6.00) (the “Second Group of 2006
Options”), which Second Group of 2006 Options was subject to vesting through December 31, 2012
(the “Vesting Termination Date”);

          WHEREAS, the Original Option Agreement was superseded and replaced in its entirety by the
Restated Stock Option Agreement;

          WHEREAS, the Restated Stock Option Agreement provides for the Second Group of 2006 Options to
vest and become exercisable when the fair market value of the Company’s Stock is equal to or
greater than Six Dollars ($6.00) per share (as adjusted for stock splits, combinations,
recapitalizations and similar matters) (the “Vesting Price Target”);

          WHEREAS, as a result of a reverse stock split with respect to the Stock, the per-share option
exercise price and the Vesting Price Target of the Second Group of 2006 Options were each adjusted
to Thirty Dollars and Sixty Cents ($30.60) and the Option adjusted to purchase up to 294,117 shares
of Stock;

          WHEREAS, the Restated Stock Option Agreement provides for a termination date with respect to
the Second Group of 2006 Options of December 31, 2012 (the “Final Termination Date”),
subject to earlier termination in certain circumstances as set forth in the Restated Stock Option
Agreement, including Section 3 thereof;

          WHEREAS, on July 1, 2007 the Company and the Optionee entered into an amended and restated
employment agreement (the “2007 Employment Agreement”) with a term through January 1, 2011;

          WHEREAS, when the Restated Stock Option Agreement was prepared in early July 2007, it included
a forfeiture provision (the “Early Forfeiture Provision”) for the Second Group of 2006
Options to coincide with the term for the 2007 Employment Agreement, notwithstanding that the Board
of Directors did not intend to change the Vesting Termination Date or foreshorten the period in
which the Vesting Price Target could be achieved;

 

           WHEREAS, as of the date hereof, no portion of the Second Group of 2006 Options has yet vested
and become exercisable;

          WHEREAS, the Compensation Committee of the Board of Directors has approved, as of the date
hereof, an amendment to the Restated Stock Option Agreement to correct and remove the Early
Forfeiture Provision, such that the Second Group of 2006 Options shall remain outstanding until the
Vesting Termination Date regardless of whether or not the Second Group of 2006 Options becomes
vested as of January 1, 2011, subject to earlier termination in accordance with the other terms of
the Restated Stock Option Agreement, including Section 3 thereof.

          NOW, THEREFORE, the Restated Stock Option Agreement is hereby amended as follows, effective as
of the Amendment Effective Date:

     1. Amendment to the Restated Stock Option Agreement. Section 1(b) of the Restated
Stock Option Agreement is amended by deleting the following language therefrom: “provided, however,
that any portion of such Second Group of Options that has not vested as of January 1, 2011 shall be
forfeited for no consideration effective as of such date.”

     2. No Other Amendment. Except as expressly set forth in this Amendment, the Restated
Stock Option Agreement shall remain unchanged and shall continue in full force and effect according
to its terms.

     3. Governing Law; Counterparts. This Amendment shall be subject to Section 17 of the
Restated Stock Option Agreement and may be executed in several counterparts by the Parties.

     IN WITNESS WHEREOF, the Company has caused this Amendment to be executed in its name on its
behalf, as evidence of the adoption of this Amendment as of the Amendment Effective Date.

	 	 	 	 	 
	 	K12 INC.

 	 
	 	By:  	\s\ Jane M. Swift
 	 
	 	 	Jane M. Swift 	 
	 	 	Chair, Compensation Committee 	 
	 
	 	and

 	 
	 	By:  	\s\ Howard D. Polsky
 	 
	 	 	Howard D. Polsky 	 
	 	 	General Counsel and Secretaryexv10w1

Exhibit 10.1

LOAN AND SECURITY AGREEMENT

     THIS LOAN AND SECURITY AGREEMENT, dated as of February 8, 2011 (as amended, restated,
supplemented or otherwise modified from time to time, this “Agreement”) is among GENERAL
ELECTRIC CAPITAL CORPORATION (“GECC”), in its capacity as agent for Lenders (as defined
below) (together with its successors and assigns in such capacity, “Agent”), the financial
institutions who are or hereafter become parties to this Agreement as lenders (together with GECC,
collectively the “Lenders”, and each individually, a “Lender”), ONCOTHYREON INC., a
Delaware corporation (the “Borrower”), and the other U.S. Subsidiaries (defined below) who
are or hereafter become parties to this Agreement as guarantors (each a “Guarantor” and
collectively, the “Guarantors”, and together with the Borrower, each a “Loan Party”
and collectively, “Loan Parties”).

RECITALS

     Borrower wishes to borrow funds from time to time from Lenders, and Lenders desire to make
loans, advances and other extensions of credit, severally, but not jointly, to Borrower from time
to time pursuant to the terms and conditions of this Agreement.

AGREEMENT

Loan Parties, Agent and Lenders agree as follows:

1. DEFINITIONS.

     As used in this Agreement, all capitalized terms shall have the definitions as provided
herein. Any accounting term used but not defined herein shall be construed in accordance with
generally accepted accounting principles in the United States of America, as in effect from time to
time (“GAAP”) and all calculations shall be made in accordance with GAAP. The
term “financial statements” shall include the accompanying notes and schedules. All other terms
used but not defined herein shall have the meaning given to such terms in the Uniform Commercial
Code as adopted in the State of New York, as amended and supplemented from time to time (the
“UCC”).

2. LOANS AND TERMS OF PAYMENT.

     2.1. Promise to Pay. Each entity constituting the Borrower promises, jointly and severally,
to pay Agent, for the ratable accounts of Lenders, when due pursuant to the terms hereof, the
aggregate unpaid principal amount of all loans, advances and other extensions of credit made
severally by the Lenders to Borrower under this Agreement, together with interest on the unpaid
principal amount of such loans, advances and other extensions of credit at the interest rates set
forth herein.

     2.2. Term Loans.

     (a) Commitment. Subject to the terms and conditions hereof, each Lender,
severally, but not jointly, agrees to make term loans (each a “Term Loan” and
collectively, the “Term Loans”) to Borrower from time to time on any Business Day
(as defined below) during the period from the Closing Date (as defined below) until November
1, 2011 (the “Commitment Termination Date”) in an aggregate principal amount not to
exceed such Lender’s commitment as
identified on Schedule A hereto (such commitment of each Lender as it may be
amended to

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reflect assignments made in accordance with this Agreement or terminated or
reduced in accordance with this Agreement, its “Commitment”, and the aggregate of
all such commitments, the “Commitments”). Notwithstanding the foregoing, the
aggregate principal amount of the Term Loans made hereunder shall not exceed $12,500,000
(the “Total Commitment”). Each Lender’s obligation to fund a Term Loan shall be
limited to such Lender’s Pro Rata Share (as defined below) of such Term Loan. Subject to
the terms and conditions hereof, the initial Term Loan shall be made on the Closing Date in
an aggregate principal amount equal to $5,000,000 (the “Initial Term Loan”). After
the date of the Initial Term Loan and on or prior to the Commitment Termination Date,
Borrower may request one (1) additional Term Loan (the “Subsequent Term Loan”), and
if advanced in accordance with the terms and conditions hereof such Subsequent Term Loan
will be in an amount equal to $7,500,000.

     (b) Method of Borrowing. When Borrower desires a Term Loan, Borrower will
notify Agent (which notice shall be irrevocable) by facsimile (or by telephone, provided
that such telephonic notice shall be promptly confirmed in writing, but in any event on or
before the following Business Day) on the date that is five (5) Business Days prior to the
day the Term Loan is to be made (or such shorter period of time as Agent may agree). Agent
and Lenders may act without liability upon the basis of such written or telephonic notice
believed by Agent to be from any authorized officer of Borrower. Agent and Lenders shall
have no duty to verify the authenticity of the signature appearing on any such written
notice.

     (c) Funding of Term Loans. Promptly after receiving a request for a Term Loan,
Agent shall notify each Lender of the contents of such request and such Lender’s Pro Rata
Share of the requested Term Loan. Upon the terms and subject to the conditions set forth
herein, each Lender, severally and not jointly, shall make available to Agent its Pro Rata
Share of the requested Term Loan, in lawful money of the United States of America in
immediately available funds, to the Collection Account (as defined below) prior to 11:00
a.m. (New York time) on the specified date. Agent shall, unless it shall have determined
that one of the conditions set forth in Section 4.1 or 4.2, as applicable, has not been
satisfied, by 4:00 p.m. (New York time) on such day, credit the amounts received by it in
like funds to Borrower by wire transfer to, unless otherwise specified in a Disbursement
Letter (as defined below), the following deposit account of Borrower (or such other deposit
account as specified in writing by an authorized officer of Borrower and acceptable to
Agent) (the “Designated Deposit Account”):

Bank Name: Wells Fargo Bank

Bank Address: 2800 3rd Avenue, Seattle, WA 98121

ABA#: 

Account #: 

Account Name: Oncothyreon, Inc.

     (d) Notes. The Term Loans of each Lender shall be evidenced by a promissory
note substantially in the form of Exhibit A hereto (each a “Note” and,
collectively, the “Notes”), and Borrower shall execute and deliver a Note to each
Lender. Each Note shall represent the joint and several obligation of each entity
constituting the Borrower to pay to such Lender the lesser of (a) the aggregate unpaid
principal amount of all Term Loans made by such Lender to or on behalf of Borrower under
this Agreement and (b) the amount of such Lender’s Commitment, in each case together with
interest thereon as prescribed in Section 2.3(a).

     (e) Agent May Assume Funding. Unless Agent shall have received notice from a
Lender prior to the date of any particular Term Loan that such Lender will not make
available to Agent such Lender’s Pro Rata Share of such Term Loan, Agent may assume that
such Lender has

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made such amount available to it on the date of such Term Loan in accordance
with subsection (c) of this Section 2.2, and may (but shall not be obligated to), in
reliance upon such assumption, make available a corresponding amount for the account of
Borrower on such date. If and to the extent that such Lender shall not have so made such
amount available to Agent, such Lender and Borrower severally agree to repay to Agent
forthwith on demand such corresponding amount together with interest thereon, for each day
from the day such amount is made available to Borrower until the day such amount is repaid
to Agent, at (i) in the case of Borrower, a rate per annum equal to the interest rate
applicable thereto pursuant to Section 2.3(a), and (ii) in the case of such Lender, a
floating rate per annum equal to, for each day from the day such amount is made available to
Borrower until such amount is reimbursed to Agent, the weighted average of the rates on
overnight federal funds transactions among members of the Federal Reserve System, as
determined by Agent in its sole discretion (the “Federal Funds Rate”) for the first
Business Day and thereafter, at the interest rate applicable to such Term Loan. If such
Lender shall repay such corresponding amount to Agent, the amount so repaid shall constitute
such Lender’s loan included in such Term Loan for purposes of this Agreement.

     2.3. Interest and Repayment.

     (a) Interest. Each Term Loan shall accrue interest on the outstanding
principal amount thereof in arrears from the date made until such Term Loan is fully repaid
at a fixed per annum rate of interest equal to the sum of (i) the greater of (A) the
Treasury Rate (as defined below) in effect on the day that is three (3) Business Days prior
to the making of such Term Loan as determined by Agent and (B) 0.54% plus (ii)
9.45%. All computations of interest and fees calculated on a per annum basis shall be made
by Agent on the basis of a 360-day year, in each case for the actual number of days
occurring in the period for which such interest and fees are payable. Each determination of
an interest rate or the amount of a fee hereunder shall be made by Agent and shall be
conclusive, binding and final for all purposes, absent manifest error. As used herein, the
term “Treasury Rate” means a per annum rate of interest equal to the rate published by the
Board of Governors of the Federal Reserve System in Federal Reserve Statistical Release H.15
entitled “Selected Interest Rates” under the heading “U.S. Government Securities/Treasury
Constant Maturities” as the three year treasuries constant maturities rate. In the event
Release H.15 is no longer published, Agent shall select a comparable publication to
determine the U.S. Treasury note yield to maturity.

     (b) Payments of Principal and Interest.

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(i) Interest Payments. For each Term Loan, Borrower shall pay
interest to the Agent, for the ratable benefit of the Lenders, at the rate of
interest for such Term Loan determined in accordance with Section 2.3(a) in arrears
on the first day of each calendar month (each, a “Scheduled Payment Date”)
commencing on the first day of the calendar month occurring after the month during
which such Term Loan was made.

(ii) Principal Payments. For the Initial Term Loan, Borrower
shall pay principal to the Agent, for the ratable benefit of the Lenders, in
thirty-two (32) equal consecutive payments of $151,515.15 on each Scheduled Payment
Date, commencing on December 1, 2011, and a final payment of $151,515.20 on August
1, 2014 (the
“Scheduled Maturity Date”). For the Subsequent Term Loan, Borrower shall
pay principal to the Agent, for the ratable benefit of the Lenders, in thirty-two
(32) equal consecutive payments of $227,272.72 on each Scheduled Payment Date,
commencing on December 1, 2011, and a final payment of $227,272.96 on the Scheduled
Maturity Date.

(iii) Payments Generally. Notwithstanding the foregoing
provisions of this Section 2.3(b), all unpaid principal and accrued interest with
respect to any Term Loan is due and payable in full to Agent, for the ratable
benefit of Lenders, on the earlier of (A) the Scheduled Maturity Date and (B) the
date that such Term Loan otherwise becomes due and payable hereunder, whether by
acceleration of the Obligations pursuant to Section 8.2 or otherwise (the earlier of
(A) or (B), the “Applicable Term Loan Maturity Date”). Each scheduled
payment of interest or principal hereunder is referred to herein as a “Scheduled
Payment.”

     (c) No Reborrowing. Once a Term Loan is repaid or prepaid, it cannot be
reborrowed.

     (d) Payments. All payments (including prepayments) to be made by any Loan
Party under any Debt Document shall be made by wire transfer or ACH transfer in immediately
available funds (which shall be the exclusive means of payment hereunder) in U.S. dollars,
without setoff or counterclaim to the Collection Account (as defined below) before 1:00 p.m.
(New York time) on the date when due. All payments received by Agent after 1:00 p.m. (New
York time) on any Business Day or at any time on a day that is not a Business Day may, in
Agent’s sole discretion, be deemed to be received on the next Business Day. Whenever any
payment required under this Agreement would otherwise be due on a date that is not a
Business Day, such payment shall instead be due on the next Business Day, and additional
fees or interest, as the case may be, shall accrue and be payable for the period of such
extension. All Scheduled Payments due to Agent and Lenders under Section 2.3(b) shall be
effected by automatic debit of the appropriate funds from Borrower’s operating account
specified on the Automatic Payment Authorization Agreement (as defined below). As used
herein, the term “Collection Account” means the following account of Agent (or such
other account as Agent shall identify to Borrower in writing):

Bank Name: Deutsche Bank

Bank Address: New York, NY

ABA Number:

Account Number: 

Account Name: GECC HH Cash Flow Collections

Ref: Oncothyreon/CFN # HFS2893

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     (e) Withholdings and Increased Costs. All payments shall be made free and
clear of any taxes, withholdings, duties, impositions or other charges (other than taxes on
the overall net income of any Lender and comparable taxes), such that Agent and Lenders will
receive the entire amount of any Obligations (as defined below), regardless of source of
payment. If Agent or any Lender shall have determined that the introduction of or any
change in, after the date hereof, any law, treaty, governmental (or quasi-governmental)
rule, regulation, guideline or order reduces the rate of return on Agent or such Lender’s
capital as a consequence of its obligations hereunder or increases the cost to Agent or such
Lender of agreeing to make or making, funding or maintaining any Term Loan, then Borrower
shall from time to time upon demand by Agent or such Lender
(with a copy of such demand to Agent) promptly pay to Agent for its own account or for
the account of such Lender, as the case may be, additional amounts sufficient to compensate
Agent or such Lender for such reduction or for such increased cost. A certificate as to the
amount of such reduction or such increased cost submitted by Agent or such Lender (with a
copy to Agent) to Borrower shall be conclusive and binding on Borrower, absent manifest
error, provided that, neither Agent nor any Lender shall be entitled to payment of any
amounts under this Section 2.3(e) unless it has delivered such certificate to Borrower
within 180 days after the occurrence of the changes or events giving rise to the increased
costs to, or reduction in the amounts received by, Agent or such Lender. provided further
that, such 180 day limitation shall not apply to any increased costs or reductions in the
amounts received by Agent or any Lender arising from the Dodd-Frank Wall Street Reform and
Consumer Protection Act or any and all requests, rules, guidelines or directives thereunder
or issued in connection therewith, and such Act and any such requests, rules, guidelines or
directives shall be deemed to be introduced or changed after the date hereof, regardless of
the date enacted, adopted or issued. This provision shall survive the termination of this
Agreement.

     (f) Loan Records. Each Lender shall maintain in accordance with its usual
practice accounts evidencing the Obligations of Borrower to such Lender resulting from such
Lender’s Pro Rata Share of each Term Loan, including the amounts of principal and interest
payable and paid to such Lender from time to time under this Agreement. Agent shall
maintain in accordance with its usual practice a loan account on its books to record the
Term Loans and any other extensions of credit made by Lenders hereunder, and all payments
thereon made by Borrower. The entries made in such accounts shall, to the extent permitted
by applicable law, be prima facie evidence of the existence and amounts of the Obligations
recorded therein; provided, however, that no error in such account and no
failure of any Lender or Agent to maintain any such account shall affect the obligations of
Borrower to repay the Obligations in accordance with their terms.

     (g) Payment of Expenses and other Obligations. Agent is authorized to, and at
its sole election may, debit funds from Borrower’s operating account specified in the
Automatic Payment Authorization Agreement to pay all Obligations under this Agreement or any
of the other Debt Documents if and to the extent Borrower fails to promptly pay any such
amounts as and when due.

     2.4. Prepayments. Borrower can voluntarily prepay, upon five (5) Business Days’ prior written
notice to Agent, any Term Loan in full, but not in part. Upon the date of (a) any voluntary
prepayment of a Term Loan in accordance with the immediately preceding sentence or (b) any
mandatory prepayment of a Term Loan required under this Agreement (whether by acceleration of the
Obligations pursuant to Section 8.2 or otherwise), Borrower shall pay to Agent, for the ratable
benefit of the Lenders, a sum equal to (i) all outstanding principal of plus accrued and unpaid
interest on such Term Loan, (ii) the Final Payment Fee (as such term is defined in Section 2.7(d))
for such Term Loan, and (iii) a prepayment premium (as yield maintenance for the loss of a bargain
and not as a penalty) equal to: (i) 3.0% of the outstanding principal amount of such Term Loan, if
such prepayment is made on or before November 1,

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2012, (ii) 2.0% of the outstanding principal
amount of such Term Loan, if such prepayment is made after November 1, 2012 but on or before
September 1, 2013, and (iii) 1.0% of the outstanding principal amount of such Term Loan, if such
prepayment is made after September 1, 2013 but before the Scheduled Maturity Date;
provided, however, that with respect to the Initial Term Loan only, Borrower shall not be
required to pay any prepayment premium pursuant to the foregoing clause (iii) with respect to any
prepayment in full of the Initial Term Loan on or before November 1, 2011.

     2.5. Late Fees. If Agent does not receive any Scheduled Payment or other payment under any
Debt Document from any Loan Party within 5 days after its due date, then, at Agent’s election, such
Loan Party agrees to pay to Agent for the ratable benefit of all Lenders, a late fee equal to (a)
5.0% of the amount of such unpaid payment or (b) such lesser amount that, if paid, would not cause
the interest and fees paid by such Loan Party under this Agreement to exceed the Maximum Lawful
Rate (as defined below) (the “Late Fee”).

     2.6. Default Rate. All Term Loans and other Obligations shall bear interest, at the option of
Agent or upon the request of the Requisite Lenders (as defined below), from and after the
occurrence and during the continuation of an Event of Default (as defined below), at a rate equal
to the lesser of (a) 5.0% above the rate of interest applicable to such Obligations as set forth in
Section 2.3(a) immediately prior to the occurrence of the Event of Default and (b) the Maximum
Lawful Rate (the “Default Rate”). The application of the Default Rate shall not be
interpreted or deemed to extend any cure period or waive any Default or Event of Default or
otherwise limit the Agent’s or any Lender’s right or remedies hereunder. All interest payable at
the Default Rate shall be payable on demand.

     2.7. Lender Fees.

     (a) [Reserved].

     (b) Closing Fee. On the Closing Date, Borrower shall pay to Agent, for the
benefit of Lenders in accordance with their Pro Rata Shares, a non-refundable closing fee in
an amount equal to $31,250.00, which fee shall be fully earned when paid.

     (c) [Reserved].

     (d) Final Payment Fee. On the date upon which the outstanding principal amount
of any Term Loan is repaid in full, or if earlier, is required to be repaid in full (whether
by scheduled payment, voluntary prepayment, acceleration of the Obligations pursuant to
Section 8.2 or otherwise), Borrower shall pay to Agent, for the ratable accounts of Lenders,
a fee equal to 1.50% of the original principal amount of such Term Loan (the “Final
Payment Fee”), which Final Payment Fee shall be deemed to be fully-earned on the Closing
Date.

     2.8. Maximum Lawful Rate. Anything herein, any Note or any other Debt Document (as defined
below) to the contrary notwithstanding, the obligations of Loan Parties hereunder and thereunder
shall be subject to the limitation that payments of interest shall not be required, for any period
for which interest is computed hereunder, to the extent (but only to the extent) that contracting
for or receiving such payment by Agent and Lenders would be contrary to the provisions of any law
applicable to Agent and Lenders limiting the highest rate of interest which may be lawfully
contracted for, charged or received by Agent and Lenders, and in such event Loan Parties shall pay
Agent and Lenders interest at the highest rate permitted by applicable law (“Maximum Lawful
Rate”); provided, however, that if at any time thereafter the rate of interest
payable hereunder or thereunder is less than the Maximum Lawful Rate, Loan Parties shall continue
to pay interest hereunder at the Maximum Lawful Rate until such time as the total interest received
by Agent and Lenders is equal to the total interest that would have been received

6

 

had the interest
payable hereunder been (but for the operation of this paragraph) the interest rate payable since
the making of the Initial Term Loan as otherwise provided in this Agreement, any Note or any other
Debt Document.

     2.9. Authorization and Issuance of the Warrants. Borrower has duly authorized the issuance to
Lenders (or their respective affiliates or designees) of stock purchase warrants substantially in
the form
of the warrant attached hereto as Exhibit F (collectively, the “Warrants”)
evidencing Lenders’ (or their respective affiliates or designees) right to acquire (i) in
connection with the Initial Term Loan, their respective Pro Rata Share of up to 48,701 shares of
common stock of Borrower at an exercise price of $3.08 per share and (ii) if Borrower requests
advancement of the Subsequent Term Loan, their respective Pro Rata Share of up to a number of
shares of common stock of Borrower equal to the quotient, rounded down to the nearest whole share,
of (x) three percent of the original principal amount of the Subsequent Term Loan divided by (y)
the exercise price per share equal to the lesser of the 10-day trailing average of Borrower’s
common stock price, as determined as of the close of business on the Business Day immediately prior
to the funding date of the Subsequent Term Loan and Borrower’s common stock price, as determined as
of the close of business on the Business Day immediately prior to the funding date of the
Subsequent Term Loan; provided, that if application of the formula described in clause (ii)
above with respect to the Subsequent Term Loan would cause the aggregate number of shares of common
stock purchasable in connection with the Subsequent Term Loan to exceed 467,565, then the number of
shares so purchasable shall be fixed at 467,565 and the price per share shall be reduced
proportionately to maintain the net economic terms described in clause (ii) above. Each Warrant
shall expire seven (7) years from the date such Warrant is issued.

3. CREATION OF SECURITY INTEREST.

     3.1. Grant of Security Interest. As security for the prompt payment and performance, whether
at the stated maturity, by acceleration or otherwise, of all Term Loans and other debt, obligations
and liabilities of any kind whatsoever of Borrower to Agent and Lenders under the Debt Documents
(whether for principal, interest, fees, expenses, prepayment premiums, indemnities, reimbursements
or other sums, and whether or not such amounts accrue after the filing of any petition in
bankruptcy or after the commencement of any insolvency, reorganization or similar proceeding, and
whether or not allowed in such case or proceeding), absolute or contingent, now existing or arising
in the future, including but not limited to the payment and performance of any outstanding Notes,
and any renewals, extensions and modifications of such Term Loans (such indebtedness under the
Notes, Term Loans and other debt, obligations and liabilities in connection with the Debt Documents
are collectively called the “Obligations”), and as security for the prompt payment and
performance by each Guarantor of the Guaranteed Obligations as defined in the Guaranty (as defined
below), each Loan Party does hereby grant to Agent, for the benefit of Agent and Lenders, a
security interest in the property listed below (all hereinafter collectively called the
“Collateral”):

All of such Loan Party’s personal property of every kind and nature (except for
Intellectual Property, as defined in, and to the extent excluded pursuant to, Section
3.3) whether now owned or hereafter acquired by, or arising in favor of, such Loan
Party, and regardless of where located, including, without limitation, all accounts,
chattel paper (whether tangible or electronic), commercial tort claims, deposit
accounts, documents, equipment, financial assets, fixtures, goods, instruments,
investment property (including, without limitation, all securities accounts),
inventory, letter-of-credit rights, letters of credit, securities, supporting
obligations, cash, cash equivalents, any other contract rights (including, without
limitation, rights under any license agreements), or rights to the payment of money,
and general intangibles, and all books and records of such Loan Party relating
thereto, and in and against all additions, attachments, accessories and accessions to
such property, all

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substitutions, replacements or exchanges therefor, all proceeds,
insurance claims, products, profits and other rights to payments not otherwise
included in the foregoing (with each of the foregoing terms that are defined in the
UCC having the meaning set forth in the UCC). 

     Notwithstanding the foregoing, the grant of security interest herein shall not extend to and
the term “Collateral” shall not include: (i) more than 66% of the issued and outstanding voting
capital stock (but shall include 100% of all non-voting capital stock) of any Subsidiary of the
Borrower that is incorporated or organized in a jurisdiction other than the United States or any
state or territory thereof (each a “Foreign Subsidiary”); (ii) any equipment subject to a
lien described in clause (d) of the definition of Permitted Liens if the granting of a lien
hereunder in such equipment is prohibited by or would constitute a default under any agreement or
document governing such property; provided that upon the termination, lapsing or other expiration
of any such prohibition, such equipment shall automatically be subject to the security interest
granted in favor of the Agent hereunder and become part of the “Collateral”; (iii) any license or
contract (other than licenses constituting Intellectual Property, which for the avoidance of doubt
are excluded from Collateral pursuant to Section 3.3 below) to the extent and only to the extent
that the granting of such security interest in such license or contract is expressly prohibited by
any applicable statute, law or regulation, or would constitute or result in a default, breach,
right of recoupment, claim, defense, termination, right of termination, or remedy under such
license or contract, but only if such prohibition or restrictive term would not be rendered
ineffective under applicable law (including without limitation Sections 9-406, 9-407, 9-408 or
9-409 of the UCC); provided that upon the termination, lapsing or other or expiration of any such
prohibition or restrictive term, such license or contract shall automatically be subject to the
security interest granted in favor of the Agent hereunder and become part of the “Collateral”; or
(iv) the indebtedness owed to Borrower (as successor in interest to Biomira Inc.) pursuant to that
certain Promissory Note issued by Jeffrey Millard dated as of November 8, 2006 in the original
principal amount of $127,391.

     Each Loan Party hereby represents and covenants that such security interest constitutes a
valid, first priority security interest in the presently existing Collateral, and will constitute a
valid, first priority security interest in Collateral acquired after the date hereof, in each case,
with respect to priority only, subject to any Permitted Liens with respect to the Collateral. Each
Loan Party hereby covenants that it shall give written notice to Agent promptly upon the
acquisition by such Loan Party or creation in favor of such Loan Party of any commercial tort claim
after the Closing Date.

     3.2. Financing Statements. Each Loan Party hereby authorizes Agent to file UCC financing
statements with all appropriate jurisdictions to perfect Agent’s security interest (for the benefit
of itself and the Lenders) granted hereby.

     3.3. Grant of Security Interest in Proceeds of Intellectual Property. The Collateral shall
not include any intellectual property of any Loan Party, which shall be defined as any and all
copyrights and rights under copyright, trademarks, trade names, servicemarks, names and likenesses,
patents, rights and interests in patents, design rights, software, know-how and processes,
proprietary information, confidential information, domain names, data, software and trade secrets
of a Loan Party and any applications, registrations, amendments, renewals, extensions and
improvements with respect thereto, and all license and distribution agreements with any other party
with respect to any of the foregoing, together with any and all renewals, extensions, supplements
and continuations thereof, all rights to sue and other rights to use, exploit or practice any
patents, trade secrets, trademarks or copyrights (collectively, “Intellectual Property”)
now owned or hereafter acquired; provided however, that the Collateral shall
include all cash, royalty fees, other proceeds, accounts and general intangibles that consist of
rights of payment to or on behalf of a Loan Party or proceeds from the sale, licensing or other
disposition of all or any part of, or rights in, the Intellectual Property by or on behalf of a
Loan Party (“Rights to Payment”).

8

 

     3.4. Termination of Security Interest. Upon the date on which all of the Obligations (other
than contingent indemnity obligations that survive the termination of this Agreement and for which
no claim has been asserted) are indefeasibly repaid in full in cash, all of the Commitments
hereunder are
terminated, and this Agreement shall have been terminated (the “Termination Date”),
and upon receipt of a payoff letter or termination agreement executed by the Loan Parties in form
and substance acceptable to Agent, Agent shall, at Loan Parties’ sole cost and expense and without
any recourse, representation or warranty, release its Liens in the Collateral.

4. CONDITIONS OF CREDIT EXTENSIONS

     4.1. Conditions Precedent to Initial Term Loan. No Lender shall be obligated to make the
Initial Term Loan, or to take, fulfill, or perform any other action hereunder, until the following
have been delivered to the Agent (the date on which the Lenders make the Initial Term Loan after
all such conditions shall have been satisfied in a manner satisfactory to Agent or waived in
accordance with this Agreement, the “Closing Date”):

     (a) a counterpart of this Agreement duly executed by each Loan Party;

     (b) a certificate executed by the Secretary of each Loan Party, the form of which is
attached hereto as Exhibit B (the “Secretary’s Certificate”), providing
verification of incumbency and attaching (i) such Loan Party’s board resolutions approving
the transactions contemplated by this Agreement and the other Debt Documents and (ii) such
Loan Party’s governing documents;

     (c) Notes duly executed by Borrower in favor of each applicable Lender;

     (d) filed copies of UCC financing statements, collateral assignments, and terminations
statements, with respect to the Collateral, as Agent shall request;

     (e) certificates of insurance evidencing the insurance coverage, and satisfactory
additional insured and lender loss payable endorsements, in each case as required pursuant
to Section 6.4 herein;

     (f) current UCC lien, judgment, bankruptcy and tax lien search results demonstrating
that there are no other security interests or liens on the Collateral, other than Permitted
Liens (as defined below);

     (g) a Warrant in favor of each Lender (or its affiliate);

     (h) a certificate of good standing of each Loan Party from the jurisdiction of such
Loan Party’s organization and a certificate of foreign qualification from each jurisdiction
where such Loan Party’s failure to be so qualified could reasonably be expected to have a
Material Adverse Effect (as defined below), in each case as of a recent date acceptable to
Agent;

     (i) a landlord consent and/or bailee letter in favor of Agent executed by the landlord
or bailee, as applicable, for any third party location where (a) any Loan Party’s principal
place of business, (b) any Loan Party’s books or records or (c) tangible Collateral with an
aggregate value in excess of $250,000 is located, a form of which is attached hereto as
Exhibit C-1 and Exhibit C-2, as applicable (each an “Access
Agreement”);

     (j) a legal opinion of Loan Parties’ counsel, in form and substance satisfactory to
Agent;

9

 

     (k) a completed Automatic Payment Authorization Agreement, a form of which is attached
hereto as Exhibit E (the “Automatic Payment Authorization Agreement”);

     (l) a completed perfection certificate, duly executed by each Loan Party (the
“Perfection Certificate”), a form of which Agent previously delivered to Borrower;

     (m) one or more Account Control Agreements (as defined below), in form and substance
reasonably acceptable to Agent, duly executed by the applicable Loan Parties and the
applicable depository or financial institution, for each deposit and securities account to
the extent required pursuant to Section 7.10;

     (n) a pledge agreement, governed by the laws of the State of New York, in form and
substance satisfactory to Agent, executed by each applicable Loan Party and pledging to
Agent, for the benefit of itself and the Lenders, a security interest in (a) 100% of the
shares of the outstanding capital stock, of any class, of each U.S. Subsidiary (as defined
below) owned by such Loan Party, (b) 66% of the shares of the outstanding voting capital
stock and 100% of the shares of the outstanding non-voting capital stock of each Foreign
Subsidiary owned by such Loan Party and (c) any and all Indebtedness (as defined in Section
7.2 below) owing to Loan Parties, other than the indebtedness owed to Borrower (as successor
in interest to Biomira Inc.) pursuant to that certain Promissory Note issued by Jeffrey
Millard dated as of November 8, 2006 in the original principal amount of $127,391 (the
“Pledge Agreement”);

     (o) a guaranty agreement (together with any other guaranty that purports to provide for
a guaranty of the Obligation, the “Guaranty”), in form and substance satisfactory to
Agent, executed by each Guarantor;

     (p) a disbursement instruction letter, in form and substance satisfactory to Agent,
executed by each Loan Party, Agent and each Lender (the “Disbursement Letter”);

     (q) all other documents and instruments as Agent may reasonably deem necessary or
appropriate to effectuate the intent and purpose of this Agreement (together with the
Agreement, the Notes, the Warrants, the Account Control Agreements, the Access Agreements,
the Perfection Certificate, the Pledge Agreement, the Guaranty, if any, the Secretary’s
Certificate and the Disbursement Letter, and all other agreements, instruments, documents
and certificates executed and/or delivered to or in favor of Agent from time to time in
connection with this Agreement or the transactions contemplated hereby, the “Debt
Documents”); and

     (r) Agent and Lenders shall have received the fees required to be paid by Borrower, if
any, and Borrower shall have reimbursed Agent and Lenders for all fees, costs and expenses
of closing presented as of the date of this Agreement.

     4.2. Conditions Precedent to All Term Loans. No Lender shall be obligated to make any Term
Loan, including the Initial Term Loan, unless the following additional conditions have been
satisfied:

     (a) (i) all representations and warranties in Section 5 below shall be true as of the
date of such Term Loan; (ii) no Event of Default or any other event, which with the giving
of notice or the passage of time, or both, would constitute an Event of Default (such event,
a “Default”) has occurred and is continuing or will result from the making of any
Term Loan, and (iii) Agent shall have received a certificate from an authorized officer of
Borrower on behalf of Borrower and each Loan Party confirming each of the foregoing;

10

 

     (b) Agent shall have received the redelivery or supplemental delivery of the items set
forth in the following sections to the extent circumstances have changed since the Initial
Term Loan: Sections 4.1(b), (e), (f), (i) and (m);

     (c) with respect to the Subsequent Term Loan, Agent shall have received evidence
reasonably satisfactory to Agent that at the time of and after giving effect to the
Subsequent Term Loan, (1) the START trial for Borrower’s Stimuvax product is continuing or
enrollment has been discontinued because such trial has met a positive efficacy endpoint at
an interim analysis as determined by an independent data safety monitoring board overseeing
such trial, (2) at least one clinical indication continues to be studied in the Borrower’s
PX866 program in a manner consistent with similar studies conducted by Borrower in the
ordinary course of its business and consistent with its past practice, and (3) Borrower has,
at the time of and immediately after giving effect to the Subsequent Term Loan, unrestricted
cash and Cash Equivalents (as defined below) in one or more deposit accounts or securities
accounts subject to an Account Control Agreement as shown on the consolidated balance sheet
of Borrower and its consolidated Subsidiaries (collectively, “Balance Sheet Cash”)
in an amount equal to or greater than the product of (A) negative twelve (-12)
multiplied by (B) the Cash Burn Amount (as defined below); and

     (d) Agent shall have received such other documents, agreements, instruments or
information as Agent shall reasonably request.

     As used herein, the term “Cash Burn Amount” means, with respect to Borrower and its
consolidated Subsidiaries, as of any date of determination and based on the financial statements
most recently delivered to Agent and the Lenders in accordance with this Agreement:

	 	(a)	 	(i) the sum of, without duplication, (A) net income (loss), plus (B)
depreciation and amortization, minus (C) non-financed capital expenditures, in each
case of clauses (A), (B) and (C), for the immediately preceding six (6) month period on
a trailing basis, divided by (ii) six (6),

     minus

	 	(b)	 	(i) the current portion of interest bearing liabilities due and payable in the
immediately succeeding six (6) months divided by (ii) six (6).

5. REPRESENTATIONS AND WARRANTIES OF LOAN PARTIES.

     Each Loan Party, jointly and severally, represents, warrants and covenants to Agent and each
Lender that:

     5.1. Due Organization and Authorization. Each Loan Party’s exact legal name is as set forth
in the Perfection Certificate and each Loan Party is, and will remain, duly organized, existing and
in good standing under the laws of the State of its organization as specified in the Perfection
Certificate, has its chief executive office at the location specified in the Perfection
Certificate, and is, and will remain, duly qualified and licensed in every jurisdiction wherever
necessary to carry on its business and operations, except where the failure to be so qualified and
licensed could not reasonably be expected to have a Material Adverse Effect. This Agreement and
the other Debt Documents have been duly authorized, executed and delivered by each Loan Party and
constitute legal, valid and binding agreements enforceable in accordance with their terms. The
execution, delivery and performance by each Loan Party of each Debt Document executed or to be
executed by it is in each case within such Loan Party’s powers.

11

 

     5.2. Required Consents. No filing, registration, qualification with, or approval, consent or
withholding of objections from, any governmental authority or instrumentality or any other entity
or person is required with respect to the entry into, or performance by any Loan Party of, any of
the Debt Documents, except any obtained on or before the Closing Date.

     5.3. No Conflicts. The entry into, and performance by each Loan Party of, the Debt Documents
will not (a) violate any of the organizational documents of such Loan Party, (b) violate any law,
rule, regulation, order, award or judgment applicable to such Loan Party, or (c) result in any
breach of or constitute a default under, or result in the creation of any lien, claim or
encumbrance on any of such Loan Party’s property (except for liens in favor of Agent, on behalf of
itself and Lenders) pursuant to, any indenture, mortgage, deed of trust, bank loan, credit
agreement, or other Material Agreement (as defined below) to which such Loan Party is a party. As
used herein, “Material Agreement” means (i) the Small Cap Biotech Agreement (as defined
below), (ii) any agreement or contract to which such Loan Party is a party and involving the
receipt or payment of amounts in cash in the aggregate exceeding $1,000,000 per year and (iii) any
agreement or contract to which such Loan Party is a party the termination of which could reasonably
be expected to have a Material Adverse Effect. A description of all Material Agreements as of the
Closing Date is set forth on Schedule B hereto.

     5.4. Litigation. There are no actions, suits, proceedings or investigations pending against
any Loan Party or threatened against any Loan Party in a writing that has been received by any Loan
Party before any court, federal, state, provincial, municipal or other governmental department,
commission, board, bureau, agency or instrumentality, domestic or foreign, or any basis thereof,
which involves the possibility of any judgment or liability that would reasonably be expected to
have a Material Adverse Effect, or which questions the validity of the Debt Documents, or the other
documents required thereby or any action to be taken pursuant to any of the foregoing, nor does any
Loan Party have reason to believe that any such actions, suits, proceedings or investigations are
threatened. As used in this Agreement, the term “Material Adverse Effect” means a material
adverse effect on any of (a) the operations, business, assets, properties, or condition (financial
or otherwise) of Borrower, individually, or the Loan Parties taken as a whole, (b) the ability of a
Loan Party to perform any of its obligations under any Debt Document to which it is a party, (c)
the legality, validity or enforceability of any Debt Document, (d) the rights and remedies of Agent
or Lenders under any Debt Document or (e) the validity, perfection or priority of any lien in favor
of Agent, on behalf of itself and Lenders, on any of the Collateral.

     5.5. Financial Statements. All financial statements delivered to Agent and Lenders pursuant
to Section 6.3 have been prepared in accordance with GAAP (subject, in the case of unaudited
financial statements, to the absence of footnotes and normal year end audit adjustments), and since
the date of the most recent audited financial statement, no event has occurred which has had or
could reasonably be expected to have a Material Adverse Effect. There has been no material adverse
deviation from the most recent annual operating plan of Borrower delivered to Agent and Lenders in
accordance with Section 6.3.

     5.6. Use of Proceeds; Margin Stock. The proceeds of the Term Loans shall be used for working
capital and general corporate purposes. No Loan Party and no Subsidiary of any Loan Party is
engaged in the business of purchasing or selling margin stock (within the meaning of Regulations T,
U and X of the Board of Governors of the Federal Reserve System) (“Margin Stock”) or
extending credit for the purpose of purchasing Margin Stock. As of the Closing Date, except as set
forth on Schedule B, no Loan Party and no Subsidiary of any Loan Party owns any Margin
Stock.

     5.7. Collateral. Each Loan Party is the sole and lawful owner of its respective Collateral
(except as expressly permitted under this Loan Agreement), and has the sole right and lawful
authority to grant the security interest described in this Agreement. The Collateral is, and will
remain, free and clear of all
liens, claims and encumbrances of any kind whatsoever, except for (a) liens in favor of Agent,
on behalf

12

 

of itself and Lenders, to secure the Obligations, (b) liens (i) with respect to the
payment of taxes, assessments or other governmental charges or (ii) of suppliers, carriers,
materialmen, warehousemen, workmen or mechanics and other similar liens, in each case imposed by
law and arising in the ordinary course of business, and securing amounts that are not yet due or
that are being contested in good faith by appropriate proceedings diligently conducted and with
respect to which adequate reserves or other appropriate provisions are maintained on the books of
the applicable Loan Party in accordance with GAAP and which do not involve, in the judgment of
Agent, any risk of the sale, forfeiture or loss of any of the Collateral (a “Permitted
Contest”), (c) liens existing on the date hereof and set forth on Schedule B hereto,
(d) liens securing Indebtedness (as defined in Section 7.2 below) permitted under Section 7.2(c)
below, provided that (i) such liens exist prior to the acquisition of, or attach substantially
simultaneous with, or within 20 days after the, acquisition, repair, improvement or construction
of, such property financed by such Indebtedness and (ii) such liens do not extend to any property
of a Loan Party other than the property (and proceeds thereof) acquired or built, or the
improvements or repairs, financed by such Indebtedness, (e) licenses described in Section 7.3(d)
below, (f) liens in goods in favor of customs and revenue authorities arising as a matter of law,
in the ordinary course of business, to secure payment of customs duties in connection with the
importation of such goods, (g) liens in favor of other financial institutions arising in connection
with deposit or securities accounts held at such institutions, provided that pursuant to an
applicable Account Control Agreement, such liens only secure fees and service charges associated
with such accounts, as specified in each applicable Account Control Agreement, (h) deposits in the
ordinary course of business under worker’s compensation, unemployment insurance, social security
and other similar laws, or to secure the performance of bids, tenders or contracts (other than for
the repayment of borrowed money) or to secure the performance of bids, tenders or contracts (other
than for the repayment of borrowed money) or to secure indemnity, performance or other similar
bonds for the performance of bids, tenders or contracts (other than for the repayment of borrowed
money), (i) liens arising from judgments, decrees or attachments in circumstances not constituting
an Event of Default and (j) liens incurred in connection with Indebtedness expressly permitted by
Section 7.2(c) below, provided that any extensions, renewal or replacement lien shall be limited to
the property encumbered by the existing lien (all of such liens described in the foregoing clauses
(a) through (j) are called “Permitted Liens”).

     5.8. Compliance with Laws.

     (a) Each Loan Party is and will remain in compliance in all material respects with all
laws, statutes, ordinances, rules and regulations applicable to it.

     (b) Without limiting the generality of the immediately preceding clause (a), each Loan
Party further agrees that it and each of its subsidiaries is and will remain in compliance
in all material respects with all U.S. economic sanctions laws, Executive Orders and
implementing regulations as promulgated by the U.S. Treasury Department’s Office of Foreign
Assets Control (“OFAC”), and all applicable anti-money laundering and
counter-terrorism financing provisions of the Bank Secrecy Act and all regulations issued
pursuant to it. No Loan Party nor any of its subsidiaries, affiliates or joint ventures (i)
is a person or entity designated by the U.S. Government on the list of the Specially
Designated Nationals and Blocked Persons (the “SDN List”) with which a U.S. person
or entity cannot deal with or otherwise engage in business transactions, (ii) is a person or
entity who is otherwise the target of U.S. economic sanctions laws such that a U.S. person
or entity cannot deal or otherwise engage in business transactions with such person or
entity, or (iii) is controlled by (including without limitation by virtue of such person
being a director or owning voting shares or interests), or acts, directly or indirectly, for
or on behalf of, any person or entity on the SDN List or a foreign government that is the
target of
U.S. economic sanctions prohibitions such that the entry into, or performance under,
this Agreement or any other Debt Document would be prohibited under U.S. law.

13

 

     (c) Each Loan Party and each of its subsidiaries is in compliance with (i) the Trading
with the Enemy Act of 1917, Ch. 106, 40 Stat. 411, as amended, and each of the foreign
assets control regulations of the United States Treasury Department (31 CFR, Subtitle B
Chapter V, as amended) and any other enabling legislation or executive order relating
thereto, (ii) the Uniting and Strengthening America by Providing Appropriate Tools Required
to Intercept and Obstruct Terrorism Act of 2001, P.L. 107-56, as amended, and (iii) other
federal or state laws relating to “know your customer” and anti-money laundering rules and
regulations. No part of the proceeds of any Loan will be used directly or indirectly for
any payments to any government official or employee, political party, official of a
political party, candidate for political office, or anyone else acting in an official
capacity, in order to obtain, retain or direct business or obtain any improper advantage, in
violation of the United States Foreign Corrupt Practices Act of 1977.

     (d) Each Loan Party has met the minimum funding requirements of the United States
Employee Retirement Income Security Act of 1974 (as amended, “ERISA”) with respect
to any employee benefit plans subject to ERISA. No Loan Party is an “investment company” or
a company “controlled” by an “investment company” within the meaning of the Investment
Company Act of 1940.

     5.9. Intellectual Property. The Intellectual Property is and will remain free and clear of
all liens, claims and encumbrances of any kind whatsoever, except for Permitted Liens described in
clauses (b)(i) and (e) of Section 5.7. No Loan Party has or will become a party to any agreement
that would prohibit the granting of a security interest or Lien in such Loan Party’s Intellectual
Property (other than (1) this Agreement and (2) agreements with licensees permitted under the terms
and conditions of Section 7.3(d) that prohibit or restrict such Loan Party from encumbering or
assigning such license (or the Intellectual Property licensed under such license), but only to the
extent that such prohibition or restrictive terms are ineffective under applicable law, including,
without limitation, Sections 9-406, 9-407, 9-408 or 9-409 of the UCC). As of the Closing Date and
each date a Term Loan is advanced to Borrower, no Loan Party has any interest in, or title to any
Intellectual Property except as disclosed in the Perfection Certificate. Each Loan Party owns or
has rights to use all Intellectual Property material to the conduct of its business, without any
actual infringement or claimed infringement that has been asserted against and received in writing
by such Loan Party upon the rights of third parties.

     5.10. Solvency. Both before and after giving effect to each Term Loan, the transactions
contemplated herein, and the payment and accrual of all transaction costs in connection with the
foregoing, both the Borrower (individually) and the Loan Parties (on a consolidated basis) are and
will be Solvent. As used herein, “Solvent” means, with respect to the Borrower or the Loan
Parties on a particular date, that on such date (a) the fair value of the property of the Borrower
or the Loan Parties is greater than the total amount of liabilities, including contingent
liabilities, of the Borrower or the Loan Parties; (b) the present fair salable value of the assets
of the Borrower or the Loan Parties is not less than the amount that will be required to pay the
probable liability of the Borrower or the Loan Parties on its or their debts as they become
absolute and matured; (c) the Borrower or the Loan Parties do not intend to, and do not believe
that it or they will, incur debts or liabilities beyond the Borrower or the Loan Parties’ ability
to pay as such debts and liabilities mature; (d) the Borrower or the Loan Parties are not engaged
in a business or transaction, and are not about to engage in a business or transaction, for which
the Borrower or the Loan Parties’ property would constitute an unreasonably small capital; and (e)
neither the Borrower nor the Loan Parties are “insolvent” within the meaning of Section 101(32) of
the United States Bankruptcy Code (11 U.S.C. § 101, et. seq), as amended from time to time. The
amount of contingent
liabilities (such as litigation, guaranties and pension plan liabilities) at any time shall be
computed as the amount that, in light of all the facts and circumstances existing at the time
(including without limitation the contribution obligations of other guarantors), represents the
amount that can be reasonably be expected to become an actual or matured liability.

14

 

     5.11. Taxes; Pension. All federal and state (and all material local) tax returns, reports and
statements, including information returns, required by any governmental authority to be filed by
each Loan Party and its Subsidiaries have been filed with the appropriate governmental authority
and all federal and state (and all material local) taxes, levies, assessments and similar charges
have been paid prior to the date on which any fine, penalty, interest or late charge may be added
thereto for nonpayment thereof (or any such fine, penalty, interest, late charge or loss has been
paid), excluding taxes, levies, assessments and similar charges or other amounts which are the
subject of a Permitted Contest. Proper and accurate amounts have been withheld by each Loan Party
from its respective employees for all periods in compliance with applicable laws and such
withholdings have been timely paid to the respective governmental authorities. Each Loan Party has
paid all amounts necessary to fund all present pension, profit sharing and deferred compensation
plans in accordance with their terms, and no Loan Party has withdrawn from participation in, or has
permitted partial or complete termination of, or permitted the occurrence of any other event with
respect to, any such plan which could reasonably be expected to result in any liability of a Loan
Party, including any liability to the Pension Benefit Guaranty Corporation or its successors or any
other governmental authority.

     5.12. Full Disclosure. Loan Parties hereby confirm that all of the information disclosed on
the Perfection Certificate is true, correct and complete as of the date of this Agreement and is
true, correct and complete in all material respects as of the date of each Term Loan other than the
Initial Term Loan. No representation, warranty or other statement made by or on behalf of a Loan
Party contains any untrue statement of a material fact or omits to state a material fact necessary
to make the statements contained therein not misleading, it being recognized by Agent and Lenders
that the projections and forecasts provided by Loan Parties in good faith, including annual
operating plans and budgets, and based upon reasonable and stated assumptions are not to be viewed
as facts and that actual results during the period or periods covered by any such projections,
forecasts, plans and budgets may differ from the projected or forecasted results.

     5.13. Regulatory Compliance.

     (a) Each Loan Party has all authorizations, approvals, licenses, permits, certificates,
and exemptions issued or allowed by the U.S. Food and Drug Administration (“FDA”) or
any comparable governmental authority (including but not limited to new drug applications,
abbreviated new drug applications, biologics license applications, investigational new drug
applications, over-the-counter drug monograph, device pre-market approval applications,
device pre-market notifications, investigational device exemptions, product
recertifications, manufacturing approvals and authorizations, CE Marks, pricing and
reimbursement approvals, labeling approvals or their foreign equivalent, controlled
substance registrations, and wholesale distributor permits (hereinafter “Registrations”)
that are required to conduct its business as currently conducted. To the knowledge of each
Loan Party, neither the FDA nor any comparable governmental authority is considering
limiting, suspending, or revoking such Registrations or changing the marketing
classification or labeling or other significant parameter affecting the products of the Loan
Parties. To the knowledge of each Loan Party, there is no false or misleading information
or material omission in any product application or other submission to the FDA or any
comparable governmental authority. The Loan Parties have fulfilled and performed their
obligations under each Registration, and no event has occurred or condition or state of
facts
exists which would constitute a breach or default under, or would cause revocation or
termination of, any such Registration. To the knowledge of each Loan Party, any third party
that is a manufacturer or contractor for the Loan Parties is in compliance with all
Registrations required by the FDA or comparable governmental authority and all Public Health
Laws insofar as they reasonably pertain to the manufacture of product components or products
regulated as medical devices and marketed or distributed by the Loan Parties. “Public
Health Laws” means all

15

 

applicable Requirements of Law (as defined below) relating to the
procurement, development, manufacture, production, analysis, distribution, dispensing,
importation, exportation, use, handling, quality, sale, or promotion of any drug, medical
device, food, dietary supplement, or other product (including, without limitation, any
ingredient or component of the foregoing products) subject to regulation under the Federal
Food, Drug, and Cosmetic Act (21 U.S.C. et seq.) and similar state laws, controlled
substances laws, pharmacy laws, or consumer product safety laws.

     (b) All products designed, developed, manufactured, prepared, assembled, packaged,
tested, labeled, distributed or marketed by or on behalf of the Loan Parties that are
subject to the jurisdiction of the FDA or a comparable governmental authority have been and
are being designed, developed, tested, manufactured, prepared, assembled, packaged,
distributed, labeled and marketed in compliance with the Public Health Laws and all other
applicable laws, statutes, ordinances, rules and regulations (each a “Requirement of
Law”), including, without limitation, clinical and non-clinical evaluation, product
approval or clearance, good manufacturing practices, labeling, advertising and promotion,
record-keeping, establishment registration and device listing, reporting of recalls, and
adverse event reporting, and have been and are being tested, investigated, designed,
developed, manufactured, prepared, assembled, packaged, labeled, distributed, marketed, and
sold in compliance with all applicable Requirements of Law, in each case except where the
failure to comply would not reasonably be expected to have, either individually or in the
aggregate, a Material Adverse Effect.

     (c) Other than obligations arising under the Registrations in the ordinary course of
business, no Loan Party is subject to any obligation arising under an administrative or
regulatory action, proceeding, or inspection by a governmental authority, including the FDA
or any comparable governmental authority, warning letter, notice of violation letter,
consent decree, request for information or other written notice, response or commitment made
to or with the FDA or any comparable governmental authority, which if not complied with
could reasonably be expected to have a Material Adverse Effect. There is no act, omission,
event, or circumstance of which any Loan Party has knowledge that would reasonably be
expected to give rise to or lead to any civil, criminal or administrative action, suit,
demand, claim, complaint, hearing, investigation, demand letter, warning letter, proceeding
or request for information pending against any Loan Party, in each case that could
reasonably be expected to have a Material Adverse Effect. To each Loan Party’s knowledge,
no Loan Party has any liability (whether actual or contingent) for failure to comply with
any Public Health Laws that would reasonably be expected to have a Material Adverse Effect.
There has not been any violation of any Public Health Laws by any Loan Party in its product
development efforts, submissions, record keeping and reports to the FDA or any other
comparable governmental authority that would reasonably be expected to require or lead to
investigation, corrective action or enforcement, regulatory or administrative action that
would reasonably be expected to have a Material Adverse Effect. To the knowledge of each
Loan Party, there are no civil or criminal proceedings relating to any Loan Party or any
officer, director or employee of any Loan Party that involve a matter within or related to
the FDA’s any other comparable governmental authority’s jurisdiction.

     (d) As of the Closing Date, no Loan Party is undergoing any inspection related to any
activities or products of the Loan Parties that are subject to Public Health Laws, or any
other governmental authority investigation.

     (e) During the period of six calendar years immediately preceding the Closing Date, no
Loan Party has introduced into commercial distribution any products manufactured by or on
behalf of any Loan Party or distributed any products on behalf of another manufacturer that
were

16

 

upon their shipment by any Loan Party adulterated or misbranded in violation of 21
U.S.C. § 331. The Loan Parties have not received any written notice or communication from
the FDA or comparable governmental authority alleging material noncompliance with any
Requirement of Law by any Loan Party. No product manufactured, marketed or distributed by
any Loan Party has been seized, withdrawn, recalled, detained, or subject to a suspension
(other than in the ordinary course of business) of research, manufacturing, distribution or
commercialization activity, and there are no facts or circumstances reasonably likely to
cause (i) the seizure, denial, withdrawal, recall, detention, public health notification,
safety alert or suspension of manufacturing or other activity relating to any such product;
(ii) a change in the labeling of any product suggesting a compliance issue or other risk; or
(iii) a termination, seizure or suspension of manufacturing, researching, distributing or
marketing of any product manufactured, marketed or distributed by any Loan Party. No
proceedings in the United States or any other jurisdiction seeking the withdrawal, recall,
revocation, suspension, import detention, or seizure of any product manufactured by or on
behalf of any Loan Party are pending or threatened against any Loan Party in a writing that
has been received by any Loan Party.

     (f) No Loan Party nor, to the knowledge of any Loan Party, any of its respective
officers, directors, employees, agents or contractors (i) have been excluded or debarred
from any federal healthcare program (including without limitation Medicare or Medicaid) or
any other federal program or (ii) have received notice from the FDA or any other comparable
governmental authority with respect to debarment or disqualification of any person that
would reasonably be expected to have a Material Adverse Effect. No Loan Party nor, to the
knowledge of any Loan Party, any of its respective officers, directors, employees, agents or
contractors have been convicted of any crime or engaged in any conduct for which (x)
debarment is mandated or permitted by 21 U.S.C. § 335a or (y) such person or entity could be
excluded from participating in the federal health care programs under Section 1128 of the
Social Security Act or any similar law. No officer and to the knowledge of each Loan Party,
no employee or agent of any Loan Party, has (aa) made any untrue statement of material fact
or fraudulent statement to the FDA or any other comparable governmental authority; (bb)
failed to disclose a material fact required to be disclosed to the FDA or any other
comparable governmental authority; or (cc) committed an act, made a statement, or failed to
make a statement that would reasonably be expected to provide the basis for the FDA or any
other comparable governmental authority to invoke its policy respecting “Fraud, Untrue
Statements of Material Facts, Bribery, and Illegal Gratuities,” as set forth in 56 Fed. Reg.
46191 (September 10, 1991).

     (g) Other than pursuant to Material Agreements and other agreements described on
Schedule B hereto, no Loan Party has granted rights to design, develop, manufacture,
produce, assemble, distribute, license, prepare, package, label, market or sell its products
to any other person (other than pursuant to research collaborations entered into in the
ordinary course of business) nor is it bound by any agreement that affects any Loan Party’s
exclusive right to design, develop, manufacture, produce, assemble, distribute, license,
prepare, package, label, market or sell its products.

     (h) Each product in distribution by a Loan Party is, and for the past six years has,
been designed, manufactured, prepared, assembled, packaged, labeled, stored, and processed
in compliance in all material respects with current Good Manufacturing Practices as set
forth in 21 CFR Parts 210 and 211 to the extent applicable. Each Loan Party is in compliance
in all material respects with the written procedures, record-keeping and reporting
requirements required by the FDA or any comparable governmental authority pertaining to the
reporting of adverse events and recalls involving such Loan Party’s products. Each Loan
Party’s products in distribution are and

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have been labeled, promoted, and advertised in
accordance with their Registration or within the scope of an exemption from obtaining such
Registration.

6. AFFIRMATIVE COVENANTS.

     6.1. Good Standing. Except as expressly permitted pursuant to Section 7.5, each Loan
Party shall maintain its and each of its Subsidiaries’ existence and good standing in its
jurisdiction of organization and maintain qualification in each jurisdiction in which the failure
to so qualify could reasonably be expected to have a Material Adverse Effect. Each Loan Party
shall maintain, and shall cause each of its Subsidiaries to maintain, in full force all licenses,
approvals and agreements, the loss of which could reasonably be expected to have a Material Adverse
Effect. “Subsidiary” means, with respect to a Loan Party, any entity the management of
which is, directly or indirectly controlled by, or of which an aggregate of more than 50% of the
outstanding voting capital stock (or other voting equity interest) is, at the time, owned or
controlled, directly or indirectly by, such Loan Party or one or more Subsidiaries of such Loan
Party, and, unless the context otherwise requires each reference to a Subsidiary herein shall be a
reference to a Subsidiary of Borrower.

     6.2. Notice to Agent. Loan Parties shall provide Agent with (a) notice of any change in any
material respect (except that in each case such materiality qualifier shall not be applicable to
any representation or warranty that already is expressly qualified or modified by materiality in
the text thereof) in the accuracy of the Perfection Certificate or any of the representations and
warranties provided in Section 5 above, promptly (but in any event within 3 Business Days) after
the date on which any officer of a Loan Party obtains knowledge of the occurrence of any such
change (b) notice of the occurrence of any Default or Event of Default, promptly (but in any event
within 3 Business Days) after the date on which any officer of a Loan Party obtains knowledge of
such occurrence, (c) copies of all material statements, reports and notices delivered by any Loan
Party to its securityholders or to Small Cap Biotech (as defined below) under the Small Cap Biotech
Agreement, and all material notices sent to any Loan Party by Small Cap Biotech, and all documents
filed with the Securities and Exchange Commission (“SEC”) or any securities exchange or
governmental authority exercising a similar function, promptly, but in any event within 3 Business
Days of delivering or receiving such information to or from such persons, in each case with any
confidential or proprietary information therein redacted to the extent necessary to comply with any
confidentiality agreement with Small Cap Biotech, (d) a report of any legal actions pending or
threatened in writing against and delivered to any Loan Party or any Subsidiary that could result
in damages or costs to any Loan Party or any Subsidiary of $250,000 or more promptly, but in any
event within 3 Business Days, upon receipt of written notice thereof by a Loan Party, including
without limitation any such legal actions alleging potential or actual violations of any Public
Health Law, (e) a list of any new domestic and any material new foreign applications or
registrations that any Loan Party has made or filed in respect of any Intellectual Property or a
material change in status of any outstanding application or registration with respect to
Intellectual Property, to be delivered with the next succeeding compliance certificate required to
be delivered pursuant to Section 6.3, (f) notice of any amendments to, and copies of all
material statements, reports and notices (other than statements, reports and notices delivered in
the ordinary course of business) delivered to or by a Loan Party in connection with, any Material
Agreement promptly (but in any event within 3 Business Days) upon execution or receipt
thereof, (g) any notice that the FDA or comparable governmental authority is limiting,
suspending or revoking any Registration, changing the market classification, distribution pathway
or parameters or labeling of the products of the Loan Parties, or considering any of the foregoing,
promptly (but in any event within 3 Business Days) of Borrower’s receiving written notice of such
change or consideration or (h) notice that any Loan Party has become subject to any administrative
or regulatory action, FDA inspection, Form FDA 483 observation, warning letter, notice of violation
letter, or other enforcement action, notice, response or commitment made to or with the FDA or any
comparable governmental authority, or notice that any product of any Loan Party has been seized,
withdrawn, recalled, detained, or

18

 

subject to a suspension of manufacturing, or the commencement of
any proceedings in the United States or any other jurisdiction seeking the withdrawal, recall,
suspension, import detention, or seizure of any product are pending or threatened against any Loan
Party, promptly (but in any event within 3 Business Days) of Borrower’s receiving written notice of
such action or event; provided that, with respect to any statements, reports, notices or
other documents that are filed with the SEC by the Borrower and are required to be delivered to the
Agent under this Section 6.2 or under Section 6.3, notification by the Borrower to the Agent of
such filing with the SEC shall constitute delivery to the Agent.

     6.3. Financial Statements. Borrower shall deliver to Agent (x) if requested by Agent,
unaudited consolidated and, if available, consolidating balance sheets, statements of operations
and cash flow statements within 30 days of each month end, in a form acceptable to Agent and
certified by Borrower’s president, chief executive officer or chief financial officer, and (y)
quarterly unaudited consolidated and, if available, consolidating balance sheets, statements of
operations and cash flow statements and annual audited consolidated and, if available,
consolidating balance sheets, statements of operations and cash flow statements, certified by a
recognized firm of certified public accountants, within 5 days after the statements are required to
be provided to the SEC (after giving effect to any grace period provided by Rule 12b-25 under the
Exchange Act). All audited financial statements delivered pursuant to this Section 6.3 shall be
accompanied by the report of an independent certified public accounting firm approved by Borrower’s
audit committee which report shall (i) contain an unqualified opinion, stating that such
consolidated financial statements present fairly in all material respects the financial position
for the periods indicated in conformity with GAAP applied on a basis consistent with prior years
and (ii) not include any explanatory paragraph expressing substantial doubt as to going concern
status. All such statements are to be prepared using GAAP (subject, in the case of unaudited
financial statements, to the absence of footnotes and normal year end audit adjustments) and are to
be in compliance with applicable SEC requirements. All financial statements delivered pursuant to
this Section 6.3 shall be accompanied by a compliance certificate, signed by the chief financial
officer of Borrower, in the form attached hereto as Exhibit D. Borrower shall deliver to
Agent (i) as soon as available and in any event not later than 30 days after the end of each fiscal
year of Borrower, an annual operating plan for Borrower, on a consolidated and, if available,
consolidating basis, approved by the Board of Directors of Borrower, for the current fiscal year,
in form and substance reasonably satisfactory to Agent and (ii) such budgets, sales projections, or
other business, financial, corporate affairs and other information as Agent or any Lender may
reasonably request from time to time.

     6.4. Insurance. Each Loan Party, at its expense, shall maintain, and shall cause each
Subsidiary to maintain, insurance (including, without limitation, comprehensive general liability,
hazard, and business interruption insurance) with respect to all of its properties and businesses
(including, the Collateral), in such amounts and covering such risks as is carried generally in
accordance with sound business practice by companies in similar businesses similarly situated and
in any event with deductible amounts, insurers and policies that shall be reasonably acceptable to
Agent. Borrower shall deliver to Agent certificates of insurance evidencing such coverage,
together with endorsements to such policies naming Agent as a lender loss payee or additional
insured, as appropriate, in form and substance satisfactory to Agent. Each policy shall provide
that coverage may not be canceled or altered by the
insurer except upon 30 days prior written notice to Agent and shall not be subject to
co-insurance (except for retentions and deductibles that are set forth in such policies in
accordance with sound business practice by companies in similar businesses similarly situated and
in any event in amounts that are reasonably acceptable to Agent). Each Loan Party appoints Agent
as its attorney-in-fact, if an Event of Default has occurred and is continuing, to make, settle and
adjust all claims under and decisions with respect to such Loan Party’s policies of insurance, and
to receive payment of and execute or endorse all documents, checks or drafts in connection with
insurance payments. Agent shall not act as such Loan Party’s attorney-in-fact unless an Event of
Default has occurred and is continuing. The appointment of Agent as any Loan Party’s attorney in
fact is a power coupled with an interest and is irrevocable until the

19

 

Termination Date. So long as
no Default or Event of Default has occurred and is continuing, proceeds of insurance not to exceed
$1,000,000 in the aggregate during the term of this Loan Agreement may be applied, at the option of
Borrower, to repair or replace the damaged or lost Collateral with similar property used or useful
in the Borrower’s business (so long as such repair or replacement occurs less than 180 days after
the date such proceeds are received) or to reduce any of the Obligations. During the existence of
a Default or Event of Default, proceeds of insurance shall be applied, at the option of Agent, to
repair or replace the Collateral or to reduce any of the Obligations.

     6.5. Taxes. Each Loan Party shall, and shall cause each Subsidiary to, timely file all
federal and state tax (and all material local) reports and pay and discharge all federal and state
(and all material local) taxes, assessments and governmental charges or levies imposed upon it, or
its income or profits or upon its properties or any part thereof, before the same shall be in
default and before the date on which penalties attach thereto, except to the extent such taxes,
assessments and governmental charges or levies are the subject of a Permitted Contest.

     6.6. Agreement with Landlord/Bailee. Unless otherwise agreed to by the Agent in writing, each
Loan Party shall obtain and maintain such Access Agreement(s) with respect to any real property on
which (a) a Loan Party’s principal place of business, (b) a Loan Party’s books or records or (c)
tangible Collateral with an aggregate value in excess of $250,000 is located (other than real
property owned by such Loan Party) as Agent may require.

     6.7. Protection of Intellectual Property. Each Loan Party shall take all necessary actions
to: (a) protect, defend and maintain the validity and enforceability of its Intellectual Property
to the extent material to the conduct of its business now or heretofore conducted by it or proposed
to be conducted by it, (b) promptly advise Agent in writing of material infringements of its
Intellectual Property of which any Executive Officer of Borrower has knowledge and, should the
Intellectual Property be material to such Loan Party’s business, take all commercially reasonable
actions to enforce its rights in its Intellectual Property against infringement, misappropriation
or dilution and to recover any and all damages for such infringement, misappropriation or dilution,
(c) not allow any Intellectual Property material to such Loan Party’s business to be abandoned,
forfeited or dedicated to the public without Agent’s written consent (which consent shall not be
unreasonably delayed), and (d) notify Agent promptly, but in any event within 3 Business Days, if
it knows or has reason to know that any application or registration relating to any patent,
trademark or copyright (now or hereafter existing) material to its business is reasonably likely to
become abandoned or dedicated, or if it receives written notice of any material adverse
determination or development (including the institution of, or any such determination or
development in, any proceeding in the United States Patent and Trademark Office, the United States
Copyright Office or any court) regarding such Loan Party’s ownership of any Intellectual Property
material to its business, its right to register the same, or to keep and maintain the same. Each
Loan Party shall remain liable under each of its Intellectual Property licenses pursuant to which
it is a licensee (“Licenses”) to observe and perform all of the conditions and obligations
to be observed and performed by it thereunder, unless the failure to observe or perform such
conditions or obligations could not reasonably be expected to have in a Material Adverse
Effect. None of Agent or any Lender shall have any obligation or liability under any such
License by reason of or arising out of this Agreement, the granting of a lien, if any, in such
License or the receipt by Agent (on behalf of itself and Lenders) of any payment relating to any
such License. None of Agent or any Lender shall be required or obligated in any manner to perform
or fulfill any of the obligations of a Loan Party under or pursuant to any License, or to make any
payment, or to make any inquiry as to the nature or the sufficiency of any payment received by it
or the sufficiency of any performance by any party under any License, or to present or file any
claims, or to take any action to collect or enforce any performance or the payment of any amounts
which may have been assigned to it or which it may be entitled at any time or times.

20

 

     6.8. Special Collateral Covenants.

     (a) Each Loan Party shall remain in possession of and shall remain the sole lawful
owner of its respective Collateral solely at the location(s) specified on the Perfection
Certificate, except to the extent expressly permitted under Sections 7.3 or
7.5 hereof; except that Agent, on behalf of itself and Lenders, shall have the right
to possess (i) any chattel paper or instrument that constitutes a part of the Collateral,
(ii) any other Collateral in which Agent’s security interest (on behalf of itself and
Lenders) may be perfected only by possession and (iii) any Collateral after the occurrence
of an Event of Default in connection with the exercise of its remedies hereunder and in
accordance with this Agreement and the other Debt Documents.

     (b) Each Loan Party shall (i) use the Collateral only in its trade or business, (ii)
maintain all of the Collateral in good operating order and repair, normal wear and tear
excepted, and (iii) use and maintain the Collateral only in compliance with manufacturers’
recommendations and all applicable laws in all material respects.

     (c) Agent and Lenders do not authorize and each Loan Party agrees it shall not (i) part
with possession of any of the tangible Collateral (except to Agent (on behalf of itself and
Lenders), for maintenance and repair or for a Permitted Disposition), or (ii) remove any
tangible Collateral from, or maintain any of the tangible Collateral outside, the
continental United States, except as expressly permitted pursuant to Sections 7.2, 7.5 and
7.7.

     (d) Each Loan Party shall pay promptly when due all federal and state (and all material
local) taxes, assessments and governmental charges or levies levied or assessed on any of
the Collateral on its use, or on this Agreement or any of the other Debt Documents (unless
contested pursuant to a Permitted Contest). At its option, Agent may discharge taxes,
liens, security interests or other encumbrances at any time levied or placed on the
Collateral and may pay for the maintenance, insurance and preservation of the Collateral and
effect compliance with the terms of this Agreement or any of the other Debt Documents. Each
Loan Party agrees to reimburse Agent, on demand, all reasonable costs and expenses incurred
by Agent in connection with such payment or performance and agrees that such reimbursement
obligation shall constitute Obligations.

     (e) Each Loan Party shall, at all times, keep accurate and complete records of the
Collateral.

     (f) Each Loan Party agrees and acknowledges that any third person who may at any time
possess all or any portion of the Collateral consisting of inventory or equipment shall be
deemed to hold, and shall hold, the Collateral as the agent of, and as pledge holder for,
Agent (on behalf of itself and Lenders). Agent may at any time give notice to any third
person described in
the preceding sentence that such third person is holding the Collateral as the agent
of, and as pledge holder for, Agent (on behalf of itself and Lenders).

     (g) Each Loan Party shall, during normal business hours, and in the absence of a
Default or an Event of Default, upon one Business Day’s prior notice, as frequently as Agent
determines to be appropriate, but without unreasonably interfering with such Loan Party’s
ordinary business: (i) provide Agent (who may be accompanied by representatives of any
Lender) and any of its officers, employees and agents access to the properties, facilities,
advisors and employees (including officers) of each Loan Party and to the Collateral, (ii)
permit Agent (who may be accompanied by representatives of any Lender), and any of its
officers, employees and agents, to inspect, audit and make extracts from any Loan Party’s
books and records (or at the request of Agent, deliver true and correct copies of such books
and records to Agent), and (iii)

21

 

permit Agent (who may be accompanied by representatives of
any Lender), and its officers, employees and agents, to inspect, audit, appraise, review,
evaluate and make test verifications and counts of the Collateral of any Loan Party. Upon
Agent’s written request, each Loan Party will promptly notify Agent in writing of the
location of any Collateral. If a Default or Event of Default has occurred and is continuing
or if access is necessary to preserve or protect the Collateral as determined by Agent, each
such Loan Party shall provide such access to Agent and to each Lender at all times and
without advance notice. Each Loan Party shall make available to Agent and its auditors or
counsel, as promptly as is possible under the circumstances, originals or copies of all
books and records that Agent may reasonably request. In connection with any inspection,
audit, appraisal, review, or evaluation conducted pursuant to this Section 6.8(g),
the Loan Parties agree, jointly and severally, to pay or reimburse upon demand all
reasonable fees, costs and expenses incurred by Agent; provided, however,
that unless a Default or Event of Default has occurred, the Borrower shall not be obligated
to reimburse Agent for more than two such inspections, audits, appraisals, reviews, or
evaluations conducted pursuant to this Section 6.8(g) during any calendar year.

     6.9. [Reserved].

     6.10. Further Assurances. Each Loan Party shall, upon request of Agent, furnish to Agent such
further information, execute and deliver to Agent such documents and instruments (including,
without limitation, UCC financing statements) and shall do such other acts and things as Agent may
at any time reasonably request relating to the perfection or protection of the security interest
created by this Agreement or for the purpose of carrying out the intent of this Agreement and the
other Debt Documents.

     6.11. Compliance with Law. Each Loan Party shall comply with all applicable statutes, rules,
regulations, standards, guidelines, policies and orders administered or issued by any governmental
authority having jurisdiction over it or its business, except where the failure to comply would not
reasonably be expected to have, either individually or in the aggregate, a Material Adverse Effect.
Without limiting the generality of the foregoing, each Loan Party shall comply in all material
respects with all Public Health Laws and their implementation by any applicable governmental
authority and all lawful requests of any governmental authority applicable to such Loan Party’s
products. All products developed, manufactured, tested, distributed or marketed by or on behalf of
any Loan Party that are subject to the jurisdiction of the FDA or comparable governmental authority
shall be developed, tested, manufactured, distributed and marketed in compliance with the Public
Health Laws and any other Requirements of Law, including, without limitation, product approval or
premarket notification, good manufacturing practices, labeling, advertising, record-keeping, and
adverse event reporting, and have been and are being tested, investigated, distributed, marketed,
and sold in compliance with Public Health
Laws and all other Requirements of Law, in each case except where the failure to comply would
not reasonably be expected to have, either individually or in the aggregate, a Material Adverse
Effect.

     6.12. Additional Subsidiaries. At the time of or prior to the formation or acquisition of any
Subsidiary of Borrower, Borrower shall cause to be executed and delivered to Agent the following:
(i) by such new Subsidiary other than a Foreign Subsidiary, a Guaranty pursuant to which such
Subsidiary shall guarantee the payment and performance of all of the Obligations and pursuant to
which Agent, for the benefit of itself and the Lenders, shall be granted a first priority (subject
to Permitted Liens) and perfected security interest in all assets of such Subsidiary of the same
types constituting “Collateral” under Section 3.1 hereof to secure the Obligations, (ii) by the
Borrower or any Guarantor (as applicable) that is such Subsidiary’s direct parent company, an
amendment to the Pledge Agreement delivered on the Closing Date or a new Pledge Agreement, governed
by the laws of the State of New York, substantially in the form of the Pledge Agreement delivered
on the Closing Date (or otherwise in form and substance reasonably satisfactory to Lender), as
applicable, and pursuant to which either (1) 100% of the shares of

22

 

the outstanding capital stock,
of any class, of each U.S. Subsidiary or (2) 66% of the shares of the outstanding voting capital
stock and 100% of the shares of the outstanding non-voting capital stock of each Foreign Subsidiary
shall be pledged to Agent pursuant to such Pledge Agreement, for the benefit of the Lenders, on a
first priority and perfected basis under the UCC to secure the Obligations, and (iii) by the
Borrower, such other related documents (including closing certificates, legal opinions and other
similar documents) as Agent may reasonably request, all in form and substance reasonably
satisfactory to Agent; provided, however, that this Section 6.12 shall not operate
as a consent to any formation or acquisition of a Subsidiary that is not expressly permitted
pursuant to the terms and conditions of this Agreement.

7. NEGATIVE COVENANTS

     7.1. Liens. No Loan Party shall, and no Loan Party shall permit any of its Subsidiaries to,
create, incur, assume or permit to exist any lien, security interest, claim or encumbrance on any
Collateral or Intellectual Property, except for Permitted Liens, or become a party to any agreement
that prohibits the granting of a security interest in or Lien on such Loan Party’s Collateral or
Intellectual Property (other than (1) this Agreement and (2) agreements with licensees permitted
under the terms and conditions of Section 7.3(d) that prohibit or restrict such Loan Party from
encumbering or assigning such license (or the Intellectual Property licensed under such license),
but only to the extent that such prohibition or restrictive terms are ineffective under applicable
law of the United States or any state thereof, including, without limitation, Sections 9-406,
9-407, 9-408 or 9-409 of the UCC).

     7.2. Indebtedness. Subject to Section 7.14, no Loan Party shall, and no Loan Party shall
permit any of its Subsidiaries to, directly or indirectly create, incur, assume, permit to exist,
guarantee or otherwise become or remain directly or indirectly liable with respect to, any
Indebtedness (as hereinafter defined), except for (a) the Obligations, (b) Indebtedness existing on
the date hereof and set forth on Schedule B to this Agreement, (c) Indebtedness consisting of
capitalized lease obligations and purchase money Indebtedness, in each case incurred by Borrower or
any of its Subsidiaries to finance the acquisition, repair, improvement or construction of fixed or
capital assets of such person, provided that (i) the aggregate outstanding principal amount of all
such Indebtedness does not exceed $500,000 at any time and (ii) the principal amount of such
Indebtedness does not exceed the lower of the cost or fair market value of the property so acquired
or built or of such repairs or improvements financed with such Indebtedness (each measured at the
time of such acquisition, repair, improvement or construction is made), (d) extensions,
refinancings, modifications, amendments and restatements of Indebtedness set forth in clause (b) or
(c) above (such Indebtedness, “Original Indebtedness”), provided that such
extension, refinancing, modification, amendment or restatement (i) shall have an aggregate
outstanding
principal amount not greater than the aggregate principal amount of such Original Indebtedness
outstanding at the time of such refinancing, (ii) shall have a maturity no shorter than that of
such refinanced Original Indebtedness, (iii) shall not be secured by any property or any lien other
than those already securing such refinanced Original Indebtedness and (iv) shall not otherwise be
on terms less favorable to the Loan Parties, taken as a whole, than those of such Original
Indebtedness, (e) Indebtedness owing by any Loan Party to another Loan Party, provided that (i)
each Loan Party shall have executed and delivered to each other Loan Party a demand note (each, an
“Intercompany Note”) to evidence such intercompany loans or advances owing at any time by
each Loan Party to the other Loan Parties, which Intercompany Note shall be in form and substance
reasonably satisfactory to Agent and shall be pledged and delivered to Agent pursuant to the Pledge
Agreement as additional Collateral for the Obligations, (ii) any and all Indebtedness of any Loan
Party to another Loan Party shall be subordinated to the Obligations pursuant to the subordination
terms set forth in each Intercompany Note, and (iii) no Default or Event of Default would occur as
a result of the incurrence of such Indebtedness at the time of the incurrence of such Indebtedness,
and (f) other unsecured Indebtedness in an aggregate principal amount not to exceed $100,000 at any
time. The term “Indebtedness” shall mean, with respect to any

23

 

person, at any date, without
duplication, (i) all obligations of such person for borrowed money, (ii) all obligations of such
person evidenced by bonds, debentures, notes or other similar instruments, or upon which interest
payments are customarily made, (iii) all obligations of such person to pay the deferred purchase
price of property or services, but excluding obligations to trade creditors incurred in the
ordinary course of business and not past due by more than 90 days, (iv) all capital lease
obligations of such person, (v) the principal balance outstanding under any synthetic lease, tax
retention operating lease, off-balance sheet loan or similar off-balance sheet financing product,
(vi) all obligations of such person to purchase securities (or other property) which arise out of
or in connection with the issuance or sale of the same or substantially similar securities (or
property), (vii) all contingent or non-contingent obligations of such person to reimburse any bank
or other person in respect of amounts paid under a letter of credit or similar instrument, (viii)
all equity securities of such person subject to repurchase or redemption otherwise than at the sole
option of such person, (ix) contingent obligations of such person under an acquisition agreement
(but, for the avoidance of doubt, not including any agreement pursuant to which such person
licenses the right to use Intellectual Property) to pay amounts to the seller based on the
performance of the assets acquired thereunder, (x) all indebtedness secured by a lien on any asset
of such person, whether or not such indebtedness is otherwise an obligation of such person, (xi)
all net obligations of such person under any foreign exchange contract, currency swap agreement,
interest rate swap, cap or collar agreement or other similar agreement or arrangement designed to
alter the risks of that person arising from fluctuations in currency values or interest rates, in
each case whether contingent or matured, and (xii) all obligations or liabilities of others of the
types specified in clauses (i) through (xi) guaranteed by such person. For the avoidance of doubt,
“Indebtedness” does not include non-cash intercompany liabilities which arise from the transfer of
costs due from services performed on behalf of one Loan Party or Subsidiary to another Loan Party
or Subsidiary.

     7.3. Dispositions. No Loan Party shall, and no Loan Party shall permit any of its
Subsidiaries to, convey, sell, rent, lease, sublease, mortgage, license, transfer or otherwise
dispose of (collectively, “Transfer”) any of the Collateral or any Intellectual Property,
except for the following (collectively, “Permitted Dispositions”): (a) sales of inventory
in the ordinary course of business, (b) (1) Transfers of obsolete or worn-out equipment by a Loan
Party or any of its Subsidiaries, and (2) dispositions by a Loan Party or any of its Subsidiaries
of tangible assets that are no longer used or useful in the business of such Loan Party or such
Subsidiary for cash and fair value so long as (i) no Default or Event of Default exists at the time
of such disposition or would be caused after giving effect thereto and (ii) the fair market value
of all such assets disposed of does not exceed $250,000 in any fiscal year, (c) Borrower may cause
its subsidiary B.C. ULC, a Canada unlimited liability corporation, to dispose of up to 100% of the
capital stock of its subsidiary Oncothyreon Canada, a Canada corporation, pursuant to documentation
in form
and substance satisfactory to Agent, to acquire the rights to Oncothyreon Canada’s net
operating losses, (d) non-exclusive and exclusive licenses for the use of any Loan Party’s
Intellectual Property in the ordinary course of business, so long as, with respect to each such
license, (i) no Default or Event of Default has occurred or is continuing on the date of such
license agreement, (ii) the license constitutes an arms-length transaction in the ordinary course
of business (and in the case of an exclusive license, made in connection with a bona fide corporate
collaboration in the ordinary course of business and approved by the board of directors of the
applicable Loan Party) and the terms of which, on their face, do not provide for a sale or
assignment of any Intellectual Property and do not restrict such Loan Party’s ability to pledge,
grant a security interest in or lien on or assign or sell any Intellectual Property (other than
terms that prohibit or restrict such Loan Party or Subsidiary from pledging, granting a security
interest in or lien on or assigning or selling such license (or the Intellectual Property subject
to such license), but only to the extent that such prohibition or restrictive terms are ineffective
under applicable law of the United States or any state thereof, including, without limitation,
Sections 9-406, 9-407, 9-408 or 9-409 of the UCC), (iii) if such license is entered into by a Loan
Party after the date of this Agreement, such Loan Party delivers at least thirty (30) days’ prior
written notice and a brief summary of the terms of the license to Agent, (iv) unless such license
(or a redacted form thereof) is filed with the SEC, the applicable Loan

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Party delivers to Agent
copies of the final executed licensing documents in connection with the license promptly upon
consummation of the license, with any confidential or proprietary information therein redacted to
the extent necessary to comply with such license agreement, and (v) all royalties, milestone
payments or other proceeds arising from the licensing agreement are paid to a deposit account that
is subject to an Account Control Agreement, and (e) Transfers that are expressly permitted under
Section 7.1, 7.2, 7.5, 7.6 or 7.7.

     7.4. Change in Name, Location or Executive Office; Change in Business; Change in Fiscal Year.
No Loan Party shall, and no Loan Party shall permit any of its Subsidiaries to, (a) change its name
or its state of organization, unless (i) such Loan Party has given at least 30 days’ prior written
notification to Agent, (ii) such Loan Party has received written confirmation from Agent (which
confirmation shall not be unreasonably delayed) that Agent has taken all actions necessary to
continue the perfection of Agent’s liens on the Collateral of such Loan Party, and (iii) such Loan
Party has executed and delivered to Agent such agreements and documents as reasonably requested by
Agent in connection therewith, (b) relocate its chief executive office without at least 30 days’
prior written notification to Agent, (c) engage in any business other than or reasonably related or
incidental to the businesses currently engaged in by such Loan Party or Subsidiary, (d) except in
connection with any transaction expressly permitted pursuant to Section 7.3 or 7.5,
cease to conduct business substantially in the manner conducted by such Loan Party or Subsidiary as
of the date of this Agreement or (e) without at least 30 days’ prior written notification to Agent,
change its fiscal year end except to conform to the fiscal year end of Borrower.

     7.5. Mergers or Acquisitions. No Loan Party shall merge or consolidate, and no Loan Party
shall permit any of its Subsidiaries to merge or consolidate, with or into any other person or
entity (other than mergers or consolidations of (i) a Subsidiary into Borrower in which Borrower is
the surviving entity, (ii) a Subsidiary into any other Loan Party in which such Loan Party is the
surviving entity and (iii) a Subsidiary which is not a Loan Party into a Subsidiary which is not a
Loan Party) or acquire, or permit any of its Subsidiaries to acquire, all or substantially all of
the capital stock or property of another person or entity or all or substantially all of the assets
constituting any line of business, division, branch, operating division or other unit operation of
another person or entity. For the avoidance of doubt, this Section 7.5 shall not
prohibit any Transfer that qualifies as a Permitted Disposition pursuant to the terms and
conditions of Section 7.3.

     7.6. Restricted Payments. Subject to Section 7.14, no Loan Party shall, and no Loan Party
shall permit any of its Subsidiaries to, (a) declare or pay any dividends or make any other
distribution or
payment on account of or redeem, retire, defease or purchase any capital stock of the Borrower
or its Subsidiaries (other than (i) the payment of dividends to Borrower, or the payment of
dividends by any Foreign Subsidiary to its parent entity, and (ii) so long as no Default or Event
of Default shall have occurred and be continuing, the repurchase of capital stock pursuant to the
terms of employee stock purchase plans, employee restricted stock agreements or similar
arrangements or by the cancellation of Indebtedness issued to purchase capital stock, such
repurchase and cancellation and any related option exchange or re-pricings, in an aggregate amount
not to exceed $100,000 during the term of this Agreement), (b) purchase, redeem, defease or prepay
any principal of, premium, if any, interest or other amount payable in respect of any Indebtedness
(other than the Obligations) prior to its scheduled maturity, (c) make any payment in respect of
management fees or consulting fees (or similar fees) to any equityholder or other affiliate of
Borrower, other than payments made pursuant to bona fide consulting agreements entered into by a
Loan Party in the ordinary course of business, or (d) be a party to or bound by an agreement that
restricts a Subsidiary from paying dividends or otherwise distributing property to Borrower in
respect of the Capital Stock of such Subsidiary.

     7.7. Investments. No Loan Party shall, and no Loan Party shall permit any of its Subsidiaries
to, directly or indirectly (a) acquire or own, or make any loan, advance or capital contribution
(an

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“Investment”; for the avoidance of doubt, “Investment” does not include non-cash
intercompany receivables which arise from the transfer of costs due to services performed on behalf
of one Loan Party or Subsidiary from another Loan Party or Subsidiary) in or to any person or
entity, (b) acquire or create any Subsidiary (other than the creation of (1) Subsidiaries organized
in a jurisdiction of the United States or any state or territory thereof (each, a “U.S.
Subsidiary”) or (2) other Subsidiaries acquired or created for tax purposes, in each case, to
engage in businesses reasonably related or incidental to the businesses engaged in by the Loan
Parties as of the Closing Date, provided that each of the conditions set forth in Section
6.12 shall have been satisfied on or prior to the date such Subsidiary is created), or (c)
engage in any joint venture or partnership with any other person or entity, other than: (i)
Investments existing on the date hereof and set forth on Schedule B to this Agreement, (ii)
Investments in cash and Cash Equivalents (as defined below), (iii) loans or advances to employees
of Borrower or any of its Subsidiaries to finance travel, entertainment and relocation expenses and
other ordinary business purposes in the ordinary course of business as presently conducted,
provided that the aggregate outstanding principal amount of all loans and advances permitted
pursuant to this clause (iii) shall not exceed $250,000 at any time; (iv) Investments (including
debt obligations) received pursuant to an order of the court in connection with the bankruptcy or
reorganization of customers or suppliers and in settlement of delinquent obligations of, and other
disputes with, customers or suppliers; (v) Investments consisting of credit extended to customers
who are not Affiliates, in the ordinary course of business and on payment terms customary for the
industry and regions in which Borrower operates (which payment terms shall not in any event exceed
90 days from the date of invoice), (vi) Investments consisting of promissory notes received from
employees, officers or directors (so long as no cash is advanced by Borrower in connection
therewith) to finance the purchase of equity securities of Borrower pursuant to employee stock
purchase plan agreements approved by Borrower’s Board of Directors; (vii) Investments by any Loan
Party in another Loan Party (provided that the Borrower shall give Agent prior written notice of
any such Investment); (viii) Investments by a Loan Party in Subsidiaries that are not Loan Parties
in an amount not to exceed $250,000 in any fiscal year; (ix) Investments by a Subsidiary that is
not a Loan Party in other Subsidiaries that are not Loan Parties; (x) Investments consisting of
in-licensed Intellectual Property in an aggregate amount not to exceed $3,000,000 during the term
of this Agreement; and (xi) other Investments in an aggregate amount not to exceed $50,000 at any
time (collectively, the “Permitted Investments”). The term “Cash Equivalents”
means (v) any readily-marketable securities (i) issued by, or directly, unconditionally and fully
guaranteed or insured by the United States federal government or (ii) issued by any agency of the
United States federal government the obligations of which are fully backed by the full faith and
credit of the United States federal government, (w) any readily-marketable direct obligations
issued by any other agency of the United States federal government, any state of the United States
or any political subdivision of any such state or any public instrumentality thereof, in each case
having a rating of at least “A-1” from S&P or at least “P-1” from Moody’s, (x) any commercial paper
rated at least “A-1” by S&P or “
P-1” by Moody’s and issued by any entity organized
under the laws of any state of the United States, (y) any U.S. dollar-denominated time deposit,
insured certificate of deposit, overnight bank deposit or bankers’ acceptance issued or accepted by
(i) Agent or (ii) any commercial bank that is (A) organized under the laws of the United States,
any state thereof or the District of Columbia, (B) “adequately capitalized” (as defined in the
regulations of its primary federal banking regulators) and (C) has Tier 1 capital (as defined in
such regulations) in excess of $250,000,000 or (z) shares of any United States money market fund
that (i) has substantially all of its assets invested continuously in the types of investments
referred to in clause (v), (w), (x) or (y) above with maturities as set
forth in the proviso below, (ii) has net assets in excess of $500,000,000 and (iii) has obtained
from either S&P or Moody’s the highest rating obtainable for money market funds in the United
States; provided, however, that the maturities of all obligations specified in any
of clauses (v), (w), (x) and (y) above shall not exceed 365 days.
For the avoidance of doubt, “Cash Equivalents” does not include (and each Loan Party is prohibited
from purchasing or purchasing participations in) any auction rate securities or other corporate or
municipal bonds with a long-term nominal maturity for which the interest rate is reset through a
Dutch auction.

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     7.8. Transactions with Affiliates. No Loan Party shall, and no Loan Party shall permit any of
its Subsidiaries to, directly or indirectly enter into or permit to exist any transaction with any
Affiliate (as defined below) of a Loan Party or any Subsidiary of a Loan Party except for
transactions that are (i) in the ordinary course of such Loan Party’s or such Subsidiary’s business
and (ii) upon fair and reasonable terms that are no more favorable to such Affiliate than would be
obtained in an arm’s length transaction; provided, however, that transactions exclusively between
Loan Parties, the transactions described in clause (c) of the definition of “Permitted
Disposition”, and other transactions expressly permitted under Section 7.5 do not need to satisfy
the preceding clause (ii). As used herein, “Affiliate” shall mean, with respect to a Loan
Party or any Subsidiary of a Loan Party, (a) each person that, directly or indirectly, owns or
controls 5.0% or more of the stock or membership interests having ordinary voting power in the
election of directors or managers of such Loan Party or such Subsidiary, and (b) each person that
controls, is controlled by or is under common control with such Loan Party or such Subsidiary.

     7.9. Compliance. No Loan Party shall, and no Loan Party shall permit any of its Subsidiaries
to, (a) fail to comply with clauses (b) or (c) of Section 5.8 herein, (b) use any portion
of the Term Loans to purchase, become engaged in the business of purchasing or selling, or extend
credit for the purpose of purchasing or carrying Margin Stock or (c) fail to comply in any material
respect with, or violate in any material respect any other law or regulation (including without
limitation any Public Health Law) applicable to it.

     7.10. Deposit Accounts and Securities Accounts. Other than with respect to deposit accounts
used solely to fund payroll and withholding taxes, no Loan Party shall directly or indirectly
maintain or establish any deposit account or securities account, unless Agent, the applicable Loan
Party or Loan Parties and the depository institution or securities intermediary at which the
account is or will be maintained enter into a deposit account control agreement or securities
account control agreement, as the case may be, in form and substance satisfactory to Agent (an
“Account Control Agreement”) (which agreement shall provide, among other things, that (i)
such depository institution or securities intermediary has no rights of setoff or recoupment or any
other claim against such deposit or securities account (except as agreed to by Agent), other than
for payment of its service fees and other charges directly related to the administration of such
account and for returned checks or other items of payment, and (ii) such depository institution or
securities intermediary shall comply with all instructions of Agent without further consent of such
Loan Party or Loan Parties, as applicable, including, without limitation, an instruction by Agent
to comply exclusively with instructions of the Agent with respect to such account (such notice, a
“Notice of Exclusive Control”)), prior to or concurrently with the establishment of such
deposit account or securities account (or in the case of any such deposit account or securities
account maintained as of the date hereof, on or before the Closing Date). Agent may only give a
Notice of Exclusive Control with respect to any deposit account or securities account at any time
at which an Event of Default has occurred and is continuing. At the reasonable request of Agent,
Borrower shall create or designate a dedicated deposit account or accounts to be used exclusively
for payroll or withholding tax purposes.

     7.11. Amendments to Other Agreements. No Loan Party shall amend, modify or waive any
provision of (a) any Material Agreement (unless the net effect of such amendment, modification or
waiver is not materially adverse to any Loan Party, Agent or Lenders, it being understood and
agreed by the parties that any amendment, modification or waiver to a Material Agreement under
which any Loan Party pays for goods or services will not be considered adverse to Agent and Lenders
solely because such Loan Party is obligated to make payments under such Material Agreement), or (b)
any of such Loan Party’s organizational documents (unless the net effect of such amendment,
modification or waiver is not materially adverse to any Loan Party, Agent or Lenders), in each
case, without the prior written consent of Agent.

27

 

     7.12. Minimum Cash Burn Covenant. As of December 31 of each calendar year, commencing on
December 31, 2011, Borrower shall provide evidence to Agent that it has unrestricted cash and Cash
Equivalents in one or more deposit accounts or securities accounts subject to an Account Control
Agreement in an aggregate amount equal to or greater than the product of (A) negative twelve (-12)
multiplied by (B) the Cash Burn Amount at such time.

     7.13. Committed Equity Facility. At all times prior to August 1, 2012 Borrower shall (a)
maintain a $20,000,000 committed equity financing facility with Small Cap Biotech Value, Ltd., a
British Virgin Islands business company (“Small Cap Biotech”) pursuant to (1) that certain
Common Stock Purchase Agreement, dated as of July 6, 2010, by and between Borrower and Small Cap
Biotech and (2) any agreements executed in connection therewith (collectively, as the same are
amended from time to time in accordance with Section 7.11, the “Small Cap Biotech
Agreement”), and (b) have the ability to request “Fixed Requests” under (and as such term is
defined in) the Small Cap Biotech Agreement, unless the Borrower has previously requested and drawn
all committed amounts available thereunder.

     7.14. Certain Equity Transactions. Notwithstanding any provision herein or in the other Debt
Documents to the contrary, in no event shall any Equity Financing Agreement (hereinafter defined),
or performance by the Borrower of its obligations under any Equity Financing Agreement, be deemed
to be Indebtedness or a transaction prohibited by Section 7.6 (Restricted Payments) for the
purposes of any Debt Documents. “Equity Financing Agreements” means, collectively, (1) the
agreements and securities to which the Borrower is party or by which it is bound that exist on the
date hereof and are listed under the heading “Section 7.14” in Schedule B hereto and (2) any
agreements or securities that the Borrower may enter into or issue, or by which it may be bound,
after the date hereof in connection with a bona fide equity financing that contain terms and
conditions substantially the same as those in the agreements or securities described in clause (1)
of this sentence.

8. DEFAULT AND REMEDIES.

     8.1. Events of Default. Loan Parties shall be in default under this Agreement and each of the
other Debt Documents if (each of the following, an “Event of Default”):

     (a) Borrower shall fail to pay (i) any principal when due, or (ii) any interest, fees
or other Obligations (other than as specified in clause (i)) within a period of 3 days after
the due date thereof (other than on any Applicable Term Loan Maturity Date);

     (b) any Loan Party breaches any of its obligations under Section 6.1 (solely as it
relates to maintaining its existence), Section 6.2, Section 6.3, Section 6.4, or Article 7;

     (c) any Loan Party breaches any of its other obligations under any of the Debt
Documents and fails to cure such breach within 30 days after the earlier of (i) the date on
which an executive officer of such Loan Party becomes aware, or through the exercise of
reasonable diligence should have become aware, of such failure and (ii) the date on which
notice shall have been given to Borrower from Agent;

     (d) any warranty, representation or statement made or deemed made by or on behalf of
any Loan Party in any of the Debt Documents or otherwise in connection with any of the
Obligations shall be false or misleading in any material respect at the time such warranty,
representations or statement was made or deemed to be made;

     (e) (i) any of the Collateral in excess of $100,000 is subjected to attachment,
execution, levy, seizure or confiscation in any legal proceeding or otherwise, or (ii) any
legal or

28

 

administrative proceeding is commenced against any Loan Party or any of the
Collateral in excess of $100,000, in each case, which in the good faith judgment of Agent
subjects such Collateral to a material risk of attachment, execution, levy, seizure or
confiscation and such proceeding is not dismissed or no bond is posted or protective order
obtained to negate such risk within 20 days after such proceeding is commenced;

     (f) one or more judgments, orders or decrees shall be rendered against any Loan Party
or any Subsidiary of a Loan Party that exceeds by more than $100,000 any insurance coverage
applicable thereto (to the extent the relevant insurer has been notified of such claim and
has not denied coverage therefor) and either (i) enforcement proceedings shall have been
commenced by any creditor upon any such judgment, order or decree or (ii) such judgment,
order or decree shall not have been satisfied, vacated or discharged for a period of 20
consecutive days and there shall not be in effect (by reason of a pending appeal or
otherwise) any stay of enforcement thereof;

     (g) (i) any Loan Party or any Subsidiary of a Loan Party shall generally not pay its
debts as such debts become due, shall admit in writing its inability to pay its debts
generally, shall make a general assignment for the benefit of creditors, or shall cease
doing business as a going concern, (ii) any proceeding shall be instituted by or against any
Loan Party or any Subsidiary of a Loan Party seeking to adjudicate it a bankrupt or
insolvent or seeking liquidation, winding up, reorganization, arrangement, adjustment,
protection, relief, composition of it or its debts or any similar order, in each case under
any law relating to bankruptcy, insolvency or reorganization or relief of debtors or seeking
the entry of an order for relief or the appointment of a custodian, receiver, trustee,
conservator, liquidating agent, liquidator, other similar official or other official with
similar powers, in each case for it or for any substantial part of its property and, in the
case of any such proceedings instituted against (but not by or with the consent of) such
Loan Party or such Subsidiary, either such proceedings shall remain undismissed or unstayed
for a period of 45 days or more or any action sought in such proceedings shall occur or
(iii) any Loan Party or any Subsidiary of a Loan Party shall take any corporate or similar
action or any other action to authorize any action described in clause (i) or
(ii) above;

     (h) an event or development occurs which has a Material Adverse Effect;

     (i) (i) any provision of any Debt Document shall fail to be valid and binding on, or
enforceable against, a Loan Party party thereto, or (ii) any Debt Document purporting to
grant a security interest to secure any Obligation shall fail to create a valid and
enforceable security interest on any Collateral purported to be covered thereby or such
security interest shall fail or cease to be a perfected lien with the priority required in
the relevant Debt Document, or any Loan Party shall state in writing that any of the events
described in clause (i) or (ii) above shall have occurred;

     (j) (i) any Loan Party or any Subsidiary of a Loan Party defaults under any Material
Agreement (after any applicable grace period contained therein) where the damages against or
other losses incurred by such Loan Party could reasonably be expected to exceed $1,000,000
in the aggregate, (ii) (A) any Loan Party or any Subsidiary of a Loan Party fails to make
(after any applicable grace period) any payment when due (whether due because of scheduled
maturity, required prepayment provisions, acceleration, demand or otherwise) on any
Indebtedness (other than the Obligations) of such Loan Party or such Subsidiary, and in each
case, such failure related to Indebtedness having an aggregate principal amount (including
undrawn committed or available
amounts and including amounts owing to all creditors under any combined or syndicated
credit arrangement) of more than $250,000 (“Material Indebtedness”), (B) any other
event shall occur or condition shall exist under any contractual obligation relating to any
such Material

29

 

Indebtedness, if the effect of such event or condition is to accelerate, or to
permit the acceleration of (without regard to any subordination terms with respect thereto),
the maturity of such Material Indebtedness or (C) any such Material Indebtedness shall
become or be declared to be due and payable, or be required to be prepaid, redeemed,
defeased or repurchased (other than by a regularly scheduled required prepayment), prior to
the stated maturity thereof, or (iii) any Loan Party defaults under any lease agreement that
meets the criteria for the requirement of an Access Agreement under Section 6.6, and the
landlord thereunder commences any action to levy upon any Collateral or remove the Borrower
or any Collateral from the premises;

     (k) (i) any of the chief executive officer or the chief financial officer of Borrower
as of the date hereof shall cease to be involved in the day to day operations (including
research development) or management of the business of Borrower, and a successor (including
an interim successor) of such officer appropriately qualified in accordance with industry
standards is not appointed within 180 days of such cessation or involvement, (ii) the
acquisition, directly or indirectly, by any person or group (as such term is used in Section
13(d)(3) of the Securities Exchange Act of 1934) of more than twenty-five percent (25%) of
the voting power of the voting stock of Borrower by way of merger or consolidation or
otherwise, (iii) during any period of twelve consecutive calendar months, individuals who at
the beginning of such period constituted the board of directors of Borrower (together with
any new directors whose election by the board of directors of Borrower or whose nomination
for election by the stockholders of Borrower was approved by a vote of at least two-thirds
of the directors then still in office who either were directors at the beginning of such
period or whose election or nomination for election was previously so approved) cease for
any reason other than death or disability to constitute a majority of the directors then in
office, (iv) Borrower ceases to own and control, directly or indirectly, all of the economic
and voting rights associated with the outstanding voting capital stock (or other voting
equity interest) of each of its Subsidiaries (other than as permitted pursuant to the terms
and conditions of Section 7.3(c) or Section 7.5); or (v) a Fundamental Transaction
(as defined in the Form of Warrant to Purchase Common Stock issued September 28, 2010 or the
Form of Warrant to Purchase Common Stock issued May 26, 2009 (as referenced on Section 7.14
of Schedule B attached hereto), in each case as amended from time to time in accordance with
this Agreement) shall have occurred.

     (l) (i) The FDA or any other governmental authority initiates enforcement action that
causes any Loan Party to discontinue or suspend marketing of any of its products; (ii) the
FDA or any other governmental authority issues a warning letter to any Loan Party with
respect to any of its products which could reasonably be expected to have a Material Adverse
Effect; (iii) any Loan Party conducts a mandated or voluntary recall of any of its products
which could reasonably be expected to result in liability and expense to the Loan Parties of
$1,000,000 (to the extent not covered by such Loan Party’s insurance policies) or more, or
that could reasonably be expected to have a Material Adverse Effect; or (iv) any Loan Party
enters into a settlement agreement with the FDA or any other governmental authority that
results in aggregate liability as to any single or related series of transactions, incidents
or conditions, of $1,000,000 (to the extent not covered by such Loan Party’s insurance
policies) or more, or that could reasonably be expected to have a Material Adverse Effect.

     8.2. Lender Remedies. If any Event of Default has occurred and is continuing, Agent may, and
at the written request of the Requisite Lenders shall, terminate the Commitments with respect to
further Term Loans and declare any or all of the Obligations to be immediately due and payable,
without demand or notice to any Loan Party and the accelerated Obligations shall bear interest at
the Default Rate pursuant to Section 2.6, provided that, upon the occurrence of any Event of
Default specified in Section 8.1(g) above, the Obligations shall be automatically accelerated.
During the existence of an Event of Default,

30

 

Agent shall have (on behalf of itself and Lenders) all
of the rights and remedies of a secured party under the UCC, and under any other applicable law.
Without limiting the foregoing, during the existence of an Event of Default, Agent shall have the
right to, and at the written request of the Requisite Lenders shall, (a) notify any account debtor
of any Loan Party or any obligor on any instrument which constitutes part of the Collateral to make
payments to Agent (for the benefit of itself and Lenders), (b) with or without legal process, enter
any premises where the Collateral may be and take possession of and remove the Collateral from the
premises or store it on the premises, (c) sell the Collateral at public or private sale, in whole
or in part, and have the right to bid and purchase at such sale, or (d) lease or otherwise dispose
of all or part of the Collateral, applying proceeds from such disposition to the Obligations in
accordance with Section 8.4. If requested by Agent, Loan Parties shall promptly assemble the
Collateral and make it available to Agent at a place to be designated by Agent. Agent may also
render any or all of the Collateral unusable at a Loan Party’s premises and may dispose of such
Collateral on such premises without liability for rent or costs. Any notice that Agent is required
to give to a Loan Party under the UCC of the time and place of any public sale or the time after
which any private sale or other intended disposition of the Collateral is to be made shall be
deemed to constitute reasonable notice if such notice is given in accordance with this Agreement at
least 5 days prior to such action. Effective only upon the occurrence and during the continuance
of an Event of Default, each Loan Party hereby irrevocably appoints Agent (and any of Agent’s
designated officers or employees) as such Loan Party’s true and lawful attorney to: (i) take any of
the actions specified above in this paragraph; (ii) endorse such Loan Party’s name on any checks or
other forms of payment or security that may come into Agent’s possession; (iii) settle and adjust
disputes and claims respecting the accounts directly with account debtors, for amounts and upon
terms which Agent determines to be reasonable; and (iv) do such other and further acts and deeds in
the name of such Loan Party that Agent may deem necessary or desirable to enforce its rights in or
to any of the Collateral or to perfect or better perfect Agent’s security interest (on behalf of
itself and Lenders) in any of the Collateral. The appointment of Agent as each Loan Party’s
attorney in fact is a power coupled with an interest and is irrevocable until the Termination Date.
For avoidance of doubt, if no Event of Default has occurred and is continuing, Agent will not
notify any account debtor of any Loan Party or any obligor on any instrument which constitutes part
of the Collateral to make payments to Agent. Agent agrees that any exercise of its rights and
remedies in the Collateral pursuant to this Section 8.2 shall be made subject to all rights of any
licensee or sublicensee under a license or sublicense that satisfies the provisions of Section
7.3(d) of this Agreement (a “Permitted License”), and no rights of a licensee or
sublicensee under a Permitted License shall be terminated solely as a result of such exercise by
Agent.

     8.3. Additional Remedies. In addition to the remedies provided in Section 8.2 above, each Loan
Party hereby grants to Agent (on behalf of itself and Lenders) and any transferee of Collateral,
for the purpose of exercising Agent’s remedies as provided in Section 8.2, if an Event of Default
has occurred and is continuing, and for no other purpose, to the extent assignable, an irrevocable,
nonexclusive license (exercisable without payment of royalty or other compensation to any Loan
Party and subject to any exclusive licenses granted in accordance with terms and conditions of
Section 7.3(d)) to use, license or sublicense any Intellectual Property now owned or hereafter
acquired by such Loan Party, and wherever the same may be located, and including in such license
reasonable access to all media in which any of the licensed items may be recorded or stored and to
all computer software and programs used for the compilation or printout thereof; provided,
however, that nothing in this Section 8.3 is intended to create a security interest in any assets
other than to the extent provided in Article III hereof. Upon the Termination Date, the
Agent shall release the license granted pursuant to the first sentence of this Section 8.3.

     8.4. Application of Proceeds. Proceeds from any Transfer of the Collateral or the
Intellectual Property (other than Permitted Dispositions) and all payments made to or proceeds of
Collateral received by Agent, in each case, during the continuance of an Event of Default may be
applied to the Obligations in the Agent’s sole and absolute discretion; provided, however,
that nothing in this Section 8.4 is intended to create a security interest in any assets
other than to the extent provided in Article III hereof.

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9. THE AGENT.

     9.1. Appointment of Agent.

     (a) Each Lender hereby appoints GECC (together with any successor Agent pursuant to
Section 9.9) as Agent under the Debt Documents and authorizes the Agent to (a)
execute and deliver the Debt Documents and accept delivery thereof on its behalf from Loan
Parties, (b) take such action on its behalf and to exercise all rights, powers and remedies
and perform the duties as are expressly delegated to the Agent under such Debt Documents and
(c) exercise such powers as are reasonably incidental thereto. The provisions of this
Article 9 are solely for the benefit of Agent and Lenders and none of Loan Parties nor any
other person shall have any rights as a third party beneficiary of any of the provisions
hereof. In performing its functions and duties under this Agreement and the other Debt
Documents, Agent shall act solely as an agent of Lenders and does not assume and shall not
be deemed to have assumed any obligation toward or relationship of agency or trust with or
for any Loan Party or any other person. Agent shall have no duties or responsibilities
except for those expressly set forth in this Agreement and the other Debt Documents. The
duties of Agent shall be mechanical and administrative in nature and Agent shall not have,
or be deemed to have, by reason of this Agreement, any other Debt Document or otherwise a
fiduciary or trustee relationship in respect of any Lender. Except as expressly set forth
in this Agreement and the other Debt Documents, Agent shall not have any duty to disclose,
and shall not be liable for failure to disclose, any information relating to Borrower or any
of its Subsidiaries that is communicated to or obtained by GECC or any of its affiliates in
any capacity.

     (b) Without limiting the generality of clause (a) above, Agent shall have the sole and
exclusive right and authority (to the exclusion of the Lenders), and is hereby authorized,
to (i) act as the disbursing and collecting agent for the Lenders with respect to all
payments and collections arising in connection with the Debt Documents (including in any
other bankruptcy, insolvency or similar proceeding), and each person making any payment in
connection with any Debt Document to any Lender is hereby authorized to make such payment to
Agent, (ii) file and prove claims and file other documents necessary or desirable to allow
the claims of Agent and Lenders with respect to any Obligation in any proceeding described
in any bankruptcy, insolvency or similar proceeding (but not to vote, consent or otherwise
act on behalf of such Lender), (iii) act as collateral agent for Agent and each Lender for
purposes of the perfection of all liens created by the Debt Documents and all other purposes
stated therein, (iv) manage, supervise and otherwise deal with the Collateral, (v) take such
other action as is necessary or desirable to maintain the perfection and priority of the
liens created or purported to be created by the Debt Documents, (vi) except as may be
otherwise specified in any Debt Document, exercise all remedies given to Agent and the other
Lenders with respect to the Collateral, whether under the Debt Documents, applicable law or
otherwise and (vii) execute any amendment, consent or waiver under the Debt Documents on
behalf of any Lender that has consented in writing to such amendment, consent or waiver;
provided, however, that Agent hereby appoints, authorizes and directs each
Lender to act as collateral sub-agent for Agent and the Lenders for purposes of the
perfection of all liens with respect to the Collateral, including any deposit account
maintained by a Loan Party with, and cash and cash equivalents held by, such Lender, and may
further authorize and direct the Lenders
to take further actions as collateral sub-agents for purposes of enforcing such liens
or otherwise to transfer the Collateral subject thereto to Agent, and each Lender hereby
agrees to take such further actions to the extent, and only to the extent, so authorized and
directed. Agent may, upon any term or condition it specifies, delegate or exercise any of
its rights, powers and remedies under, and delegate or perform any of its duties or any
other action with respect to, any Debt Document by or through any trustee, co-agent,
employee, attorney-in-fact and any other person

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(including any Lender). Any such person
shall benefit from this Article 9 to the extent provided by Agent.

     (c) If Agent shall request instructions from Requisite Lenders or all affected Lenders
with respect to any act or action (including failure to act) in connection with this
Agreement or any other Debt Document, then Agent shall be entitled to refrain from such act
or taking such action unless and until Agent shall have received instructions from Requisite
Lenders or all affected Lenders, as the case may be, and Agent shall not incur liability to
any person by reason of so refraining. Agent shall be fully justified in failing or
refusing to take any action hereunder or under any other Debt Document (a) if such action
would, in the opinion of Agent, be contrary to law or any Debt Document, (b) if such action
would, in the opinion of Agent, expose Agent to any potential liability under any law,
statute or regulation or (c) if Agent shall not first be indemnified to its satisfaction
against any and all liability and expense which may be incurred by it by reason of taking or
continuing to take any such action. Without limiting the foregoing, no Lender shall have
any right of action whatsoever against Agent as a result of Agent acting or refraining from
acting hereunder or under any other Debt Document in accordance with the instructions of
Requisite Lenders or all affected Lenders, as applicable.

     9.2. Agent’s Reliance, Etc. Neither Agent nor any of its affiliates nor any of their
respective directors, officers, agents, employees or representatives shall be liable for any action
taken or omitted to be taken by it or them hereunder or under any other Debt Documents, or in
connection herewith or therewith, except for damages caused by its or their own gross negligence or
willful misconduct as finally determined by a court of competent jurisdiction. Without limiting
the generality of the foregoing, Agent: (a) may treat the payee of any Note as the holder thereof
until such Note has been assigned in accordance with Section 10.1; (b) may consult with legal
counsel, independent public accountants and other experts, whether or not selected by it, and shall
not be liable for any action taken or omitted to be taken by it in good faith in accordance with
the advice of such counsel, accountants or experts; (c) shall not be responsible or otherwise incur
liability for any action or omission taken in reliance upon the instructions of the Requisite
Lenders, (d) makes no warranty or representation to any Lender and shall not be responsible to any
Lender for any statements, warranties or representations made in or in connection with this
Agreement or the other Debt Documents; (e) shall not have any duty to inspect the Collateral
(including the books and records) or to ascertain or to inquire as to the performance or observance
of any provision of any Debt Document, whether any condition set forth in any Debt Document is
satisfied or waived, as to the financial condition of any Loan Party or as to the existence or
continuation or possible occurrence or continuation of any Default or Event of Default and shall
not be deemed to have notice or knowledge of such occurrence or continuation unless it has received
a notice from Borrower or any Lender describing such Default or Event of Default clearly labeled
“notice of default”; (f) shall not be responsible to any Lender for the due execution, legality,
validity, enforceability, effectiveness, genuineness, sufficiency or value of, or the attachment,
perfection or priority of any lien created or purported to be created under or in connection with,
any Debt Document or any other instrument or document furnished pursuant hereto or thereto; and (g)
shall incur no liability under or in respect of this Agreement or the other Debt Documents by
acting upon any notice, consent, certificate or other instrument or writing (which may be by
telecopy, telegram, cable or telex) believed by it to be genuine and signed or sent or otherwise
authenticated by the proper party or parties.

     9.3. GECC and Affiliates. GECC shall have the same rights and powers under this Agreement and
the other Debt Documents as any other Lender and may exercise the same as though it were not Agent;
and the term “Lender” or “Lenders” shall, unless otherwise expressly indicated, include GECC in its
individual capacity. GECC and its affiliates may lend money to, invest in, and generally engage in
any kind of business with, Borrower, any of Borrower’s Subsidiaries, any of their Affiliates and
any person who may do business with or own securities of Borrower, any of Borrower’s Subsidiaries
or any such

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Affiliate, all as if GECC were not Agent and without any duty to account therefor to
Lenders. GECC and its affiliates may accept fees and other consideration from Borrower for
services in connection with this Agreement or otherwise without having to account for the same to
Lenders. Each Lender acknowledges the potential conflict of interest between GECC as a Lender
holding disproportionate interests in the Term Loans and GECC as Agent, and expressly consents to,
and waives, any claim based upon, such conflict of interest.

     9.4. Lender Credit Decision. Each Lender acknowledges that it has, independently and without
reliance upon Agent or any other Lender and based on the financial statements referred to in
Section 6.3 and such other documents and information as it has deemed appropriate, made its own
credit and financial analysis of each Loan Party and its own decision to enter into this Agreement.
Each Lender also acknowledges that it will, independently and without reliance upon Agent or any
other Lender and based on such documents and information as it shall deem appropriate at the time,
continue to make its own credit decisions in taking or not taking action under this Agreement.
Each Lender acknowledges the potential conflict of interest of each other Lender as a result of
Lenders holding disproportionate interests in the Term Loans, and expressly consents to, and
waives, any claim based upon, such conflict of interest.

     9.5. Indemnification. Lenders shall and do hereby indemnify Agent (to the extent not
reimbursed by Loan Parties and without limiting the obligations of Loan Parties hereunder), ratably
according to their respective Pro Rata Shares from and against any and all liabilities,
obligations, losses, damages, penalties, actions, judgments, suits, costs, expenses or
disbursements of any kind or nature whatsoever that may be imposed on, incurred by, or asserted
against Agent in any way relating to or arising out of this Agreement or any other Debt Document or
any action taken or omitted to be taken by Agent in connection therewith; provided that no
Lender shall be liable for any portion of such liabilities, obligations, losses, damages,
penalties, actions, judgments, suits, costs, expenses or disbursements resulting from Agent’s gross
negligence or willful misconduct as finally determined by a court of competent jurisdiction.
Without limiting the foregoing, each Lender agrees to reimburse Agent promptly upon demand for its
Pro Rata Share of any out-of-pocket expenses (including reasonable counsel fees) incurred by Agent
in connection with the preparation, execution, delivery, administration, modification, amendment or
enforcement (whether through negotiations, legal proceedings or otherwise) of, or legal advice in
respect of rights or responsibilities under, this Agreement and each other Debt Document, to the
extent that Agent is not reimbursed for such expenses by Loan Parties. The provisions of this
Section 9.5 shall survive the termination of this Agreement.

     9.6. Successor Agent. Agent may resign at any time by delivering notice of such resignation
to the Lenders and the Borrower, effective on the date set forth in such notice. Upon any such
resignation, the Requisite Lenders shall have the right to appoint a successor Agent. If no
successor Agent shall have been so appointed by the Requisite Lenders and shall have accepted such
appointment within 30 days after the resigning Agent’s giving notice of resignation, then the
resigning Agent may, on behalf of Lenders, appoint a successor Agent, which shall be a Lender, if a
Lender is willing to accept such appointment, or otherwise shall be a commercial bank or financial
institution or a subsidiary of a commercial bank or financial institution if such commercial bank
or financial institution is organized under the laws of the United States of America or of any
State thereof and has a combined capital and surplus of at least $300,000,000. If no successor
Agent has been appointed pursuant to the foregoing,
within 30 days after the date such notice of resignation was given by the resigning Agent, the
Requisite Lenders shall thereafter perform all the duties of Agent hereunder until such time, if
any, as the Requisite Lenders appoint a successor Agent as provided above. Upon the acceptance of
any appointment as Agent hereunder by a successor Agent, such successor Agent shall succeed to and
become vested with all the rights, powers, privileges and duties of the resigning Agent. Upon the
earlier of the acceptance of any appointment as Agent hereunder by a successor Agent or the
effective date of the resigning Agent’s resignation, the resigning Agent shall be discharged from
its duties and obligations under this Agreement

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and the other Debt Documents, except that any
indemnity rights or other rights in favor of such resigning Agent shall continue. After any
resigning Agent’s resignation hereunder, the provisions of this Section 9 shall inure to its
benefit as to any actions taken or omitted to be taken by it while it was acting as Agent under
this Agreement and the other Debt Documents.

     9.7. Setoff and Sharing of Payments. In addition to any rights now or hereafter granted under
applicable law and not by way of limitation of any such rights, upon the occurrence and during the
continuance of any Event of Default and subject to Section 9.8(e), each Lender is hereby authorized
at any time or from time to time upon the direction of Agent, without notice to Borrower or any
other person, any such notice being hereby expressly waived, to offset and to appropriate and to
apply any and all balances held by it at any of its offices for the account of Borrower (regardless
of whether such balances are then due to Borrower) and any other properties or assets at any time
held or owing by that Lender or that holder to or for the credit or for the account of Borrower
against and on account of any of the Obligations that are not paid when due. Any Lender exercising
a right of setoff or otherwise receiving any payment on account of the Obligations in excess of its
Pro Rata Share thereof shall purchase for cash (and the other Lenders or holders shall sell) such
participations in each such other Lender’s or holder’s Pro Rata Share of the Obligations as would
be necessary to cause such Lender to share the amount so offset or otherwise received with each
other Lender or holder in accordance with their respective Pro Rata Shares of the Obligations.
Borrower agrees, to the fullest extent permitted by law, that (a) any Lender may exercise its right
to offset with respect to amounts in excess of its Pro Rata Share of the Obligations and may sell
participations in such amounts so offset to other Lenders and holders and (b) any Lender so
purchasing a participation in the Term Loans made or other Obligations held by other Lenders or
holders may exercise all rights of offset, bankers’ lien, counterclaim or similar rights with
respect to such participation as fully as if such Lender or holder were a direct holder of the Term
Loans and the other Obligations in the amount of such participation. Notwithstanding the
foregoing, if all or any portion of the offset amount or payment otherwise received is thereafter
recovered from the Lender that has exercised the right of offset, the purchase of participations by
that Lender shall be rescinded and the purchase price restored without interest. The term “Pro
Rata Share” means, with respect to any Lender at any time, the percentage obtained by dividing
(x) the Commitment of such Lender then in effect (or, if such Commitment is terminated, the
aggregate outstanding principal amount of the Term Loans owing to such Lender) by (y) the Total
Commitment then in effect (or, if the Total Commitment is terminated, the outstanding principal
amount of the Term Loans owing to all Lenders).

     9.8. Advances; Payments; Non-Funding Lenders; Information; Actions in Concert.

     (a) Advances; Payments. If Agent receives any payment for the account of
Lenders on or prior to 1:00 p.m. (New York time) on any Business Day, Agent shall pay to
each applicable Lender such Lender’s Pro Rata Share of such payment on such Business Day. If
Agent receives any payment for the account of Lenders after 1:00 p.m. (New York time) on any
Business Day, Agent shall pay to each applicable Lender such Lender’s Pro Rata Share of such
payment on the next Business Day. To the extent that any Lender has failed to fund any such
payments and Term Loans (a “Non-Funding Lender”), Agent shall be entitled to set off
the funding short-fall against that Non-Funding Lender’s Pro Rata Share of all payments
received from Borrower.

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     (b) Return of Payments.

(i) If Agent pays an amount to a Lender under this Agreement in the belief
or expectation that a related payment has been or will be received by Agent from a
Loan Party and such related payment is not received by Agent, then Agent will be
entitled to recover such amount (including interest accruing on such amount at the
Federal Funds Rate for the first Business Day and thereafter, at the rate otherwise
applicable to such Obligation) from such Lender on demand without setoff,
counterclaim or deduction of any kind.

(ii) If Agent determines at any time that any amount received by Agent
under this Agreement must be returned to a Loan Party or paid to any other person
pursuant to any insolvency law or otherwise, then, notwithstanding any other term or
condition of this Agreement or any other Debt Document, Agent will not be required
to distribute any portion thereof to any Lender. In addition, each Lender will
repay to Agent on demand any portion of such amount that Agent has distributed to
such Lender, together with interest at such rate, if any, as Agent is required to
pay to a Loan Party or such other person, without setoff, counterclaim or deduction
of any kind.

     (c) Non-Funding Lenders. The failure of any Non-Funding Lender to make any
Term Loan or any payment required by it hereunder shall not relieve any other Lender (each
such other Lender, an “Other Lender”) of its obligations to make such Term Loan, but
neither any Other Lender nor Agent shall be responsible for the failure of any Non-Funding
Lender to make a Term Loan or make any other payment required hereunder. Notwithstanding
anything set forth herein to the contrary, a Non-Funding Lender shall not have any voting or
consent rights under or with respect to any Debt Document or constitute a “Lender” (or be
included in the calculation of “Requisite Lender” hereunder) for any voting or consent
rights under or with respect to any Debt Document. At Borrower’s request, Agent or a person
reasonably acceptable to Agent shall have the right with Agent’s consent and in Agent’s sole
discretion (but shall have no obligation) to purchase from any Non-Funding Lender, and each
Non-Funding Lender agrees that it shall, at Agent’s request, sell and assign to Agent or
such person, all of the Commitments and all of the outstanding Term Loans of that
Non-Funding Lender for an amount equal to the principal balance of all Term Loans held by
such Non-Funding Lender and all accrued interest and fees with respect thereto through the
date of sale, such purchase and sale to be consummated pursuant to an executed Assignment
Agreement (as defined below).

     (d) Dissemination of Information. Agent shall use reasonable efforts to
provide Lenders with any notice of Default or Event of Default received by Agent from, or
delivered by Agent to Borrower, with notice of any Event of Default of which Agent has
actually become aware and with notice of any action taken by Agent following any Event of
Default; provided that Agent shall not be liable to any Lender for any failure to do
so, except to the extent that such failure is attributable to Agent’s gross negligence or
willful misconduct as finally determined by a court of competent jurisdiction. Lenders
acknowledge that Borrower is required to provide financial statements to Lenders in
accordance with Section 6.3 hereto and agree that Agent shall have no duty to provide the
same to Lenders.

     (e) Actions in Concert. Anything in this Agreement to the contrary
notwithstanding, each Lender hereby agrees with each other Lender that no Lender shall take
any action to protect or enforce its rights arising out of this Agreement, the Notes or any
other Debt Documents (including exercising any rights of setoff) without first obtaining the
prior written consent of
Agent and Requisite Lenders, it being the intent of Lenders that any such action to
protect or

36

 

enforce rights under this Agreement and the Notes shall be taken in concert and
at the direction or with the consent of Agent and Requisite Lenders.

10. MISCELLANEOUS.

     10.1. Assignment. Subject to the terms of this Section 10.1, any Lender may make an
assignment to an assignee of, or sell participations in, at any time or times, the Debt Documents,
its Commitment, Term Loans or any portion thereof or interest therein, including any Lender’s
rights, title, interests, remedies, powers or duties thereunder. Any assignment by a Lender shall:
(i) except in the case of an assignment to a Qualified Assignee (as defined below), require the
consent of each Lender (which consent shall not be unreasonably withheld, conditioned or delayed),
(ii) require the execution of an assignment agreement in form and substance reasonably satisfactory
to, and acknowledged by, Agent (an “Assignment Agreement”); (iii) be conditioned on such
assignee Lender representing to the assigning Lender and Agent that it is purchasing the applicable
Commitment and/or Term Loans to be assigned to it for its own account, for investment purposes and
not with a view to the distribution thereof; (iv) be in an aggregate amount of not less than
$1,000,000, unless such assignment is made to an existing Lender or an affiliate of an existing
Lender or is of the assignor’s (together with its affiliates’) entire interest of the Term Loans or
is made with the prior written consent of Agent; and (v) include a payment to Agent of an
assignment fee of $3,500 (unless otherwise agreed by Agent). In the case of an assignment by a
Lender under this Section 10.1, the assignee shall have, to the extent of such assignment, the same
rights, benefits and obligations as all other Lenders hereunder. The assigning Lender shall be
relieved of its obligations hereunder with respect to its Commitment and Term Loans, as applicable,
or assigned portion thereof from and after the date of such assignment. Borrower hereby
acknowledges and agrees that any assignment shall give rise to a direct obligation of Borrower to
the assignee and that the assignee shall be considered to be a “Lender”. In the event any Lender
assigns or otherwise transfers all or any part of the Commitments and Obligations, upon the
assignee’s or the assignor’s request, Agent shall request that Borrower execute new Notes in
exchange for the Notes, if any, being assigned. Agent may amend Schedule A to this Agreement to
reflect assignments made in accordance with this Section.

     As used herein, “Qualified Assignee” means (a) any Lender and any affiliate of any
Lender and (b) any commercial bank, savings and loan association or savings bank or any other
entity which is an “accredited investor” (as defined in Regulation D under the Securities Act)
which extends credit or buys loans as one of its businesses, including insurance companies, mutual
funds, lease financing companies and commercial finance companies, in each case, which has a rating
of BBB or higher from S&P and a rating of Baa2 or higher from Moody’s at the date that it becomes a
Lender and in each case of clauses (a) and (b), which, through its applicable lending office, is
capable of lending to Borrower without the imposition of any withholding or similar taxes;
provided that no person proposed to become a Lender after the Closing Date and determined
by Agent to be acting in the capacity of a vulture fund or distressed debt purchaser shall be a
Qualified Assignee, and no person or Affiliate of such person proposed to become a Lender after the
Closing Date and that holds any subordinated debt or stock issued by any Loan Party or its
Affiliates shall be a Qualified Assignee.

     10.2. Notices. All notices, requests or other communications given in connection with this
Agreement shall be in writing, shall be addressed to the parties at their respective addresses set
forth on the signature pages hereto below such parties’ name or in the most recent Assignment
Agreement executed by any Lender (unless and until a different address may be specified in a
written notice to the other party delivered in accordance with this Section), and shall be deemed
given (a) on the date of receipt if delivered by hand, (b) on the date of sender’s receipt of
confirmation of proper transmission if sent by facsimile transmission, (c) on the next Business Day
after being sent by a nationally-recognized
overnight courier, and (d) on the fourth Business Day after being sent by registered or
certified mail, postage prepaid. As used herein, the term “Business Day” means and
includes any day other than

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Saturdays, Sundays, or other days on which commercial banks in New
York, New York are required or authorized to be closed.

     10.3. [Reserved.]

     10.4. Performance. Time is of the essence of this Agreement. This Agreement shall be
binding, jointly and severally, upon all parties described as the “Borrower” and their respective
successors and assigns, and shall inure to the benefit of Agent, Lenders, and their respective
successors and assigns.

     10.5. Payment of Fees and Expenses. Loan Parties agree, jointly and severally, to pay or
reimburse upon demand for all reasonable and documented fees, costs and expenses incurred by Agent
and Lenders in connection with (a) the investigation, preparation, negotiation, execution,
administration of, or any amendment, modification, waiver or termination of, this Agreement or any
other Debt Document, (b) any legal advice relating to Agent’s rights or responsibilities under any
Loan Document, (c) the administration of the Loans and the facilities hereunder and any other
transaction contemplated hereby or under the Debt Documents and (d) the enforcement, assertion,
defense or preservation of Agent’s and Lenders’ rights and remedies under this Agreement or any
other Debt Document, in each case of clauses (a) through (d), including, without limitation,
reasonable and documented attorney’s fees and expenses, reasonable fees and expenses of
consultants, auditors (including internal auditors) and appraisers and UCC and other corporate
search and filing fees and wire transfer fees. Borrower further agrees that such fees, costs and
expenses shall constitute Obligations. This provision shall survive the termination of this
Agreement.

     10.6. Indemnity. Each Loan Party shall and does hereby jointly and severally indemnify and
defend Agent, Lenders, and their respective successors and assigns, and their respective directors,
officers, employees, consultants, attorneys, agents and affiliates (each an “Indemnitee”)
from and against all liabilities, losses, damages, expenses, penalties, claims, actions and suits
(including, without limitation, related reasonable attorneys’ fees and the allocated costs of
in-house legal counsel) of any kind whatsoever arising, directly or indirectly, which may be
imposed on, incurred by or asserted against such Indemnitee as a result of or in connection with
this Agreement, the other Debt Documents or any of the transactions contemplated hereby or thereby
(the “Indemnified Liabilities”); provided that, no Loan Party shall have any obligation to
any Indemnitee with respect to any Indemnified Liabilities to the extent such Indemnified
Liabilities arise from the gross negligence or willful misconduct of such Indemnitee as determined
by a final non-appealable judgment of a court of competent jurisdiction. In no event shall any
Indemnitee be liable on any theory of liability for any special, indirect, consequential or
punitive damages (including, without limitation, any loss of profits, business or anticipated
savings). Each Loan Party waives, releases and agrees (and shall cause each other Loan Party to
waive, release and agree) not to sue upon any such claim for any special, indirect, consequential
or punitive damages, whether or not accrued and whether or not known or suspected to exist in its
favor. This provision shall survive the termination of this Agreement.

     10.7. Rights Cumulative. Agent’s and Lenders’ rights and remedies under this Agreement or
otherwise arising are cumulative and may be exercised singularly or concurrently. Neither the
failure nor any delay on the part of Agent or any Lender to exercise any right, power or privilege
under this Agreement shall operate as a waiver, nor shall any single or partial exercise of any
right, power or privilege preclude any other or further exercise of that or any other right, power
or privilege. NONE OF AGENT OR ANY LENDER SHALL BE DEEMED TO HAVE WAIVED ANY OF ITS RESPECTIVE
RIGHTS UNDER THIS AGREEMENT OR UNDER ANY OTHER AGREEMENT, INSTRUMENT OR
PAPER SIGNED BY BORROWER UNLESS SUCH WAIVER IS EXPRESSED IN WRITING AND SIGNED BY AGENT,
REQUISITE LENDERS OR ALL LENDERS, AS APPLICABLE. A waiver on

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any one occasion shall not be
construed as a bar to or waiver of any right or remedy on any future occasion.

     10.8. Entire Agreement; Amendments, Waivers.

     (a) This Agreement and the other Debt Documents constitute the entire agreement between
the parties with respect to the subject matter hereof and thereof and supersede all prior
understandings (whether written, verbal or implied) with respect to such subject matter.
Section headings contained in this Agreement have been included for convenience only, and
shall not affect the construction or interpretation of this Agreement.

     (b) Except for actions expressly permitted to be taken by Agent, no amendment,
modification, termination or waiver of any provision of this Agreement or any other Debt
Document, or any consent to any departure by Borrower therefrom, shall in any event be
effective unless the same shall be in writing and signed by Agent, Borrower and Lenders
having more than (x) 50% of the aggregate Commitments of all Lenders or (y) if such
Commitments have expired or been terminated, 50% of the aggregate outstanding principal
amount of the Term Loans (the “Requisite Lenders”). Except as set forth in clause
(c) below, all such amendments, modifications, terminations or waivers requiring the consent
of any Lenders shall require the written consent of Requisite Lenders.

     (c) No amendment, modification, termination or waiver of any provision of this
Agreement or any other Debt Document shall, unless in writing and signed by Agent and each
Lender directly affected thereby: (i) increase or decrease any Commitment of any Lender or
increase or decrease the Total Commitment (which shall be deemed to affect all Lenders),
(ii) reduce the principal of or rate of interest on any Obligation or the amount of any fees
payable hereunder (other than waiving the imposition of the Default Rate), (iii) postpone
the date fixed for or waive any payment of principal of or interest on any Term Loan, or any
fees hereunder, (iv) release all or substantially all of the Collateral, or consent to a
transfer of all or substantially all of the Intellectual Property, in each case, except as
otherwise expressly permitted in the Debt Documents (which shall be deemed to affect all
Lenders), (v) subordinate the lien on all or substantially all of the Collateral granted in
favor of the Agent securing the Obligations (which shall be deemed to affect all Lenders),
(vi) other than in connection with a merger of Loan Parties permitted pursuant to Section
7.5, release a Loan Party from, or consent to a Loan Party’s assignment or delegation of,
such Loan Party’s obligations hereunder and under the other Debt Documents or any Guarantor
from its guaranty of the Obligations (which shall be deemed to affect all Lenders) or (vii)
amend, modify, terminate or waive Section 8.4, 9.7 or 10.8(b) or (c).

     (d) Notwithstanding any provision in this Section 10.8 to the contrary, no amendment,
modification, termination or waiver affecting or modifying the rights or obligations of
Agent hereunder shall be effective unless signed by Borrower, Agent and Requisite Lenders.

     (e) Each Lender hereby consents to the release by Agent of any Lien held by the Agent
for the benefit of itself and the Lenders in any or all of the Collateral to secure the
Obligations upon (i) the occurrence of any Permitted Disposition pursuant to Section 7.3 and
(ii) the termination of the Commitments and the payment and satisfaction in full of the
Obligations.

     10.9. Binding Effect. This Agreement shall continue in full force and effect until the Termination Date; provided, however, that the provisions of this Section and Sections
2.3(e), 9.5, 10.5 and 10.6 and the other indemnities contained in the Debt Documents shall survive
the Termination Date. The surrender, upon payment or otherwise, of any Note or any of the other
Debt Documents evidencing

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any of the Obligations shall not affect the right of Agent to retain the
Collateral for such other Obligations as may then exist or as it may be reasonably contemplated
will exist in the future. This Agreement and the grant of the security interest in the Collateral
pursuant to Section 3.1 shall automatically be reinstated if Agent or any Lender is ever required
to return or restore the payment of all or any portion of the Obligations (all as though such
payment had never been made).

     10.10. Use of Logo. Each Loan Party authorizes Agent to use its name, logo and/or trademark
without notice to or consent by such Loan Party, in connection with certain promotional materials
that Agent may disseminate to the public. The promotional materials may include, but are not
limited to, brochures, video tape, internet website, press releases, advertising in newspaper
and/or other periodicals, lucites, and any other materials relating the fact that Agent has a
financing relationship with Borrower and such materials may be developed, disseminated and used
without Loan Parties’ review. Nothing herein obligates Agent to use a Loan Party’s name, logo
and/or trademark, in any promotional materials of Agent. Loan Parties shall not, and shall not
permit any of its respective Affiliates to, issue any press release or other public disclosure
(other than any document filed with any governmental authority relating to a public offering of the
securities of Borrower) using the name, logo or otherwise referring to General Electric Capital
Corporation, GE Healthcare Financial Services, Inc. or of any of their affiliates, the Debt
Documents or any transaction contemplated herein or therein without at least two (2) Business Days
prior written notice to and the prior written consent of Agent unless, and only to the extent that,
Loan Parties or such Affiliate is required to do so under applicable law and then, only after
consulting with Agent prior thereto.

     10.11. Waiver of Jury Trial. EACH OF LOAN PARTIES, AGENT AND LENDERS UNCONDITIONALLY WAIVE
ANY AND ALL RIGHT TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS
AGREEMENT, ANY OF THE OTHER DEBT DOCUMENTS, ANY OF THE INDEBTEDNESS SECURED HEREBY, ANY DEALINGS
AMONG LOAN PARTIES, AGENT AND/OR LENDERS RELATING TO THE SUBJECT MATTER OF THIS TRANSACTION OR ANY
RELATED TRANSACTIONS, AND/OR THE RELATIONSHIP THAT IS BEING ESTABLISHED AMONG LOAN PARTIES, AGENT
AND/OR LENDERS. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL ENCOMPASSING OF ANY AND ALL
DISPUTES THAT MAY BE FILED IN ANY COURT. THIS WAIVER IS IRREVOCABLE. THIS WAIVER MAY NOT BE
MODIFIED EITHER ORALLY OR IN WRITING. THE WAIVER ALSO SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS,
RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS AGREEMENT, ANY OTHER DEBT DOCUMENTS, OR TO ANY OTHER
DOCUMENTS OR AGREEMENTS RELATING TO THIS TRANSACTION OR ANY RELATED TRANSACTION. THIS AGREEMENT
MAY BE FILED AS A WRITTEN CONSENT TO A TRIAL BY THE COURT.

     10.12. Governing Law. THIS AGREEMENT, THE OTHER DEBT DOCUMENTS AND THE RIGHTS AND OBLIGATIONS
OF THE PARTIES HEREUNDER AND THEREUNDER SHALL IN ALL RESPECTS BE GOVERNED BY AND CONSTRUED IN
ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF NEW YORK (WITHOUT REGARD TO THE CONFLICT OF LAWS
PRINCIPLES OF SUCH STATE), INCLUDING ALL MATTERS OF CONSTRUCTION, VALIDITY AND PERFORMANCE,
REGARDLESS OF THE LOCATION OF THE COLLATERAL; PROVIDED, HOWEVER, THAT IF THE LAWS OF ANY
JURISDICTION OTHER THAN NEW YORK SHALL GOVERN IN REGARD TO THE VALIDITY, PERFECTION OR EFFECT OF
PERFECTION OF ANY LIEN OR IN REGARD TO PROCEDURAL MATTERS AFFECTING ENFORCEMENT OF ANY LIENS
IN COLLATERAL, SUCH LAWS OF SUCH OTHER JURISDICTIONS SHALL CONTINUE TO APPLY TO THAT EXTENT. IF
ANY ACTION ARISING OUT OF THIS AGREEMENT OR ANY OTHER DEBT DOCUMENT IS COMMENCED BY AGENT IN THE
STATE COURTS OF THE STATE OF NEW YORK IN THE COUNTY OF NEW YORK OR

40

 

IN THE U.S. DISTRICT COURT FOR THE SOUTHERN DISTRICT OF NEW YORK, EACH LOAN PARTY HEREBY CONSENTS TO THE JURISDICTION OF ANY SUCH
COURT IN ANY SUCH ACTION AND TO THE LAYING OF VENUE IN THE STATE OF NEW YORK. NOTWITHSTANDING THE
FOREGOING, THE AGENT AND LENDERS SHALL HAVE THE RIGHT TO BRING ANY ACTION OR PROCEEDING AGAINST ANY
LOAN PARTY (OR ANY PROPERTY) IN THE COURT OF ANY OTHER JURISDICTION THE AGENT OR THE LENDERS DEEM
NECESSARY OR APPROPRIATE IN ORDER TO REALIZE ON THE COLLATERAL OR OTHER SECURITY FOR THE
OBLIGATIONS. ANY PROCESS IN ANY SUCH ACTION SHALL BE DULY SERVED IF MAILED BY REGISTERED MAIL,
POSTAGE PREPAID, TO LOAN PARTIES AT THEIR ADDRESS DESCRIBED IN SECTION 10.2, OR IF SERVED BY ANY
OTHER MEANS PERMITTED BY APPLICABLE LAW.

     10.13. Confidentiality. Each Lender and Agent agrees to use all reasonable efforts to
maintain, in accordance with its customary practices, the confidentiality of information obtained
by it pursuant to any Debt Document and designated in writing by any Loan Party as confidential,
except that such information may be disclosed (a) with the Borrower’s prior written consent, (b) to
such Lender’s or Agent’s Related Persons (as defined below), as the case may be, that are advised
of the confidential nature of such information and are instructed to keep such information
confidential in accordance with the terms hereof (provided, however, that any such
confidential information consisting of license agreements governing the licensing of Intellectual
Property shall only be disclosed to such Lender’s or Agent’s Related Persons in connection with the
transactions contemplated by the Loan Documents), (c) to the extent such information presently is
or hereafter becomes (i) publicly available other than as a result of a breach of this Section
10.13 or (ii) available to such Lender or Agent or any of their Related Persons, as the case may
be, from a source (other than any Loan Party) not known by them to be subject to disclosure
restrictions, (d) to the extent disclosure is required by any applicable law, rule, regulation,
court decree, subpoena or other legal, administrative, governmental or regulatory request, order or
proceeding or otherwise required or demanded by any governmental authority, (e) to the extent
necessary or customary for inclusion in league table measurements, (f) (i) to the National
Association of Insurance Commissioners or any similar organization or any examiner, if requested by
the same or (ii) otherwise to the extent consisting of general portfolio information that does not
identify Loan Parties, (g) to current or prospective assignees or participants and to their
respective Related Persons, in each case to the extent such assignees, participants or Related
Persons agree to be bound by provisions substantially similar to the provisions of this Section
10.13 (and such persons or entities may disclose information to their respective Related Persons in
accordance with clause (b) above), (h) to any other party hereto, and (i) in connection with the
exercise or enforcement of any right or remedy under any Debt Document, in connection with any
litigation or other proceeding to which such Lender or Agent or any of their Related Persons is a
party or bound, or to the extent necessary to respond to public statements or disclosures by Loan
Parties or their Related Persons referring to a Lender or Agent or any of their Related Persons.
In the event of any conflict between the terms of this Section 10.13 and those of any other
contractual obligation entered into with any Loan Party (whether or not a Debt Document), the terms
of this Section 10.13 shall govern. “Related Persons” means, with respect to any person or entity,
each affiliate of such person or entity and each director, officer, employee, agent, trustee,
representative, attorney, accountant and each insurance, environmental, legal, financial and other
advisor and other consultants and agents of or to such person or entity or any of its affiliates.

     10.14. Counterparts. This Agreement may be executed in any number of counterparts and by
different parties in separate counterparts, each of which when so executed shall be deemed to be an
original and all of which when taken together shall constitute one and the same agreement.
Delivery of an executed signature page of this Agreement by facsimile transmission or electronic
transmission shall be as effective as delivery of a manually executed counterpart hereof.

[Signature Page Follows]

41

 

IN WITNESS WHEREOF, each Loan Party, Agent and Lenders, intending to be legally bound hereby, have
duly executed this Agreement in one or more counterparts, each of which shall be deemed to be an
original, as of the day and year first aforesaid.

	 	 	 	 	 
	 	BORROWER:

ONCOTHYREON INC.

 	 
	 	By:  	/s/ Robert L. Kirkman, M.D.	 
	 	 	Name:  	Robert L. Kirkman, M.D.	 
	 	 	Title:  	President	 
	 
	 	GUARANTORS:

BIOMIRA MANAGEMENT, INC.

 	 
	 	By:  	/s/ Robert L. Kirkman, M.D.	 
	 	 	Name:  	Robert L. Kirkman, M.D.	 
	 	 	Title:  	President	 
	 
	 	PROLX PHARMACEUTICALS CORPORATION

 	 
	 	By:  	/s/ Robert L. Kirkman, M.D.	 
	 	 	Name:  	Robert L. Kirkman, M.D.	 
	 	 	Title:  	President	 
	 

Address For Notices For All Loan Parties:

[Name of Loan Party]

c/o ONCOTHYREON INC.

2601 Fourth Avenue, Suite 500

Seattle, Washington 98121

Attention: Julie Eastland, Chief Financial Officer

Phone: (206) 801-2112

Facsimile: (206) 801-2101

ONCOTHYREON INC.

LOAN AND SECURITY AGREEMENT

SIGNATURE PAGE

 

 

	 	 	 	 	 
	 	AGENT AND LENDER:

GENERAL ELECTRIC CAPITAL CORPORATION

 	 
	 	By:  	/s/ Peter Gibson	 
	 	 	Name:  	Peter Gibson	 
	 	 	Title:  	Duly Authorized Signatory 	 
	 

Address For Notices:

General Electric Capital Corporation

c/o GE Healthcare Financial Services, Inc.

Two Bethesda Metro Center, Suite 600

Bethesda, Maryland 20814

Attention: Senior Vice President of Risk — Life Science Finance

Phone: (301) 961-1640

Facsimile: (301) 664-9855

With a copy to:

General Electric Capital Corporation

c/o GE Healthcare Financial Services, Inc.

Two Bethesda Metro Center, Suite 600

Bethesda, Maryland 20814

Attention: General Counsel

Phone: (301) 961-1640

Facsimile: (301) 664-9866

ONCOTHYREON INC.

LOAN AND SECURITY AGREEMENT

SIGNATURE PAGE

 

 

SCHEDULE A

COMMITMENTS

	 	 	 	 	 	 	 	 	 
	Name of Lender	 	Commitment of such Lender	 	 	Pro Rata Share	 
	General Electric Capital
Corporation
	 	$	12,500,000	 	 	 	100	%
	 
	 	 	 	 	 	 	 	 
	TOTAL
	 	$	12,500,000	 	 	 	100	%

 

 

SCHEDULE B

DISCLOSURES

 

 

EXHIBIT A

FORM OF PROMISSORY NOTE

[February __, 2011]

FOR VALUE RECEIVED, ONCOTHYREON INC., a Delaware corporation located at the address stated below
(the “Borrower”), promises to pay to the order of General Electric Capital Corporation or
any subsequent holder hereof (each, a “Lender”), the principal sum of Twelve Million and
Five Hundred Thousand and No/100 Dollars ($12,500,000) or, if less, the aggregate unpaid principal
amount of all Term Loans made by Lender to or on behalf of Borrower pursuant to the Agreement (as
hereinafter defined). All capitalized terms, unless otherwise defined herein, shall have the
respective meanings assigned to such terms in the Agreement.

This Promissory Note is issued pursuant to that certain Loan and Security Agreement, dated as of
February __, 2011, among Borrower, the guarantors from time to time party thereto, General Electric
Capital Corporation, as agent, [the other lenders signatory thereto], and Lender (as amended,
restated, supplemented or otherwise modified from time to time, the “Agreement”), is one of
the Notes referred to therein, and is entitled to the benefit and security of the Debt Documents
referred to therein, to which Agreement reference is hereby made for a statement of all of the
terms and conditions under which the loans evidenced hereby were made.

The principal amount of the indebtedness evidenced hereby shall be payable in the amounts and on
the dates specified in the Agreement. Interest thereon shall be paid until such principal amount
is paid in full at such interest rates and at such times as are specified in the Agreement. The
terms of the Agreement are hereby incorporated herein by reference.

All payments shall be applied in accordance with the Agreement. The acceptance by Lender of any
payment which is less than payment in full of all amounts due and owing at such time shall not
constitute a waiver of Lender’s right to receive payment in full at such time or at any prior or
subsequent time.

All amounts due hereunder and under the other Debt Documents are payable in the lawful currency of
the United States of America. Borrower hereby expressly authorizes Lender to insert the date value
as is actually given in the blank space on the face hereof and on all related documents pertaining
hereto.

This Note is secured as provided in the Agreement and the other Debt Documents. Reference is
hereby made to the Agreement and the other Debt Documents for a description of the properties and
assets in which a security interest has been granted, the nature and extent of the security
interest, the terms and conditions upon which the security interest was granted and the rights of
the holder of the Note in respect thereof.

Time is of the essence hereof. If Lender does not receive from Borrower payment in full of any
Scheduled Payment or any other sum due under this Note or any other Debt Document within 3 days
after its due date, Borrower agrees to pay the Late Fee in accordance with the Agreement. Such
Late Fee will be immediately due and payable, and is in addition to any other costs, fees and
expenses that Borrower may owe as a result of such late payment.

This Note may be voluntarily prepaid only as permitted under Section 2.4 of the Agreement. After
an Event of Default, this Note shall bear interest at a rate per annum equal to the Default Rate
pursuant to Section 2.6 of the Agreement.

 

 

Borrower and all parties now or hereafter liable with respect to this Note, hereby waive
presentment, demand for payment, notice of nonpayment, protest, notice of protest, notice of
dishonor, and all other notices in connection herewith, as well as filing of suit (if permitted by
law) and diligence in collecting this Note or enforcing any of the security hereof, and agree to
pay (if permitted by law) all expenses incurred in collection, including reasonable attorneys’ fees
and expenses, including without limitation, the allocated costs of in-house counsel.

THIS NOTE SHALL BE CONSTRUED IN ACCORDANCE WITH AND GOVERNED BY THE LAWS OF THE STATE OF NEW YORK.

No variation or modification of this Note, or any waiver of any of its provisions or conditions,
shall be valid unless such variation or modification is made in accordance with Section 10.8 of the
Agreement. Any such waiver, consent, modification or change shall be effective only in the
specific instance and for the specific purpose given.

IN WITNESS WHEREOF, Borrower has duly executed this Note as of the date first above written.

	 	 	 	 	 	 
	 	ONCOTHYREON INC.

 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 	 	Federal Tax ID #: 	
 	 
	 	 	Address: 	
 	 

 

 

	 	 	 	 	 

EXHIBIT B

SECRETARY’S CERTIFICATE OF AUTHORITY

[DATE]

          Reference is made to the Loan and Security Agreement, dated as of [_______ ___, ___] (as
amended, restated, supplemented or otherwise modified from time to time, the “Agreement”),
among [Borrower Name], a [__________] [corporation/limited liability company/limited liability
partnership/limited partnership] (the “Borrower”), the guarantors from time to time party
thereto, General Electric Capital Corporation, a Delaware corporation (“GECC”), as a lender
and as agent (in such capacity, together with its successors and assigns in such capacity,
“Agent”), and the other lenders signatory thereto from time to time (GECC and such other
lenders, the “Lenders”). Capitalized terms used but not defined herein are used with the
meanings assigned to such terms in the Agreement.

I, [_________________________], do hereby certify that:

(i) I am the duly elected, qualified and acting [Assistant] Secretary of [INSERT NAME OF LOAN
PARTY] (the “Company”);

(ii) attached hereto as Exhibit A is a true, complete and correct copies of the Company’s
[Certificate/Articles of Incorporation or Articles of Organization/Certificate of Formation] and
the [Bylaws/LLC Agreement/Partnership Agreement], each of which is in full force and effect on and
as of the date hereof;

(iii) each of the following named individuals is a duly elected or appointed, qualified and acting
officer of the Company who holds the offices set opposite such individual’s name, and such
individual is authorized to sign the Debt Documents to which the Company is a party and all other
notices, documents, instruments and certificates to be delivered pursuant thereto, and the
signature written opposite the name and title of such officer is such officer’s genuine signature:

	 	 	 	 	 
	Name	 	Title	 	Signature
	 	 	 	 	 
	 
	 	 
	 	 
	 	 	 	 	 
	 
	 	 
	 	 
	 	 	 	 	 
	 
	 	 
	 	 

(iv) attached hereto as Exhibit B are true, complete and correct copies of resolutions
adopted by the Board of Directors/Members of the Company (the “Board”) authorizing the
execution, delivery and performance of the Debt Documents to which the Company is a party, which
resolutions were duly adopted by the Board on [DATE] and all such resolutions are in full force and
effect on the date hereof in the form in which adopted without amendment, modification, rescission
or revocation;

(v) the foregoing authority shall remain in full force and effect, and Agent and each Lender shall
be entitled to rely upon same, until written notice of the modification, rescission or revocation
of same, in whole or in part, has been delivered to Agent and each Lender, but no such
modification, rescission or
revocation shall, in any event, be effective with respect to any documents executed or actions
taken in

 

 

reliance upon the foregoing authority before said written notice is delivered to Agent and
each Lender; and

(vi) no Default or Event of Default exists under the Agreement, and all representations and
warranties of the Company in the Debt Documents are true and correct in all respects on and as of
the date hereof, except to the extent such representations and warranties expressly relate to an
earlier date, in which case such representations and warranties were true and correct in all
respects on and as of such earlier date.

[Signature Page Follows]

 

 

IN WITNESS WHEREOF, I have hereunto set my hand as of the first date written above

	 	 	 	 	 
	 	 	 
	 	  	
 	 
	 	 	Name:  	 	 
	 	 	Title:  	[Assistant] Secretary 	 
	 

     The undersigned does hereby certify on behalf of the Company that he/she is the duly elected
or appointed, qualified and acting [TITLE] of the Company and that [NAME FROM ABOVE] is the duly
elected or appointed, qualified and acting [Assistant] Secretary of the Company, and that the
signature set forth immediately above is his/her genuine signature.

	 	 	 	 	 
	 	 	 
	 	  	

 	 
	 	 	Name:  	       	 
	 	 	Title:  	 	 
	 

 

 

EXHIBIT B TO SECRETARY’S CERTIFICATE OF AUTHORITY

FORM OF RESOLUTIONS

BOARD RESOLUTIONS

_____________ ___, 200_

WHEREAS, [__________], a __________ _________ (“Borrower”) has requested that General
Electric Capital Corporation, a Delaware corporation (“GECC”), as agent (in such capacity,
the “Agent”) and lender, and certain other lenders (GECC and such other lenders,
collectively, the “Lenders”) provide a credit facility in an original principal amount not
to exceed $[______________] (the “Credit Facility”); and

WHEREAS, the terms of the Credit Facility are set forth in a loan and security agreement by and
among Borrower, the guarantors from time to time party thereto, Agent, and the Lenders and certain
related agreements, documents and instruments described in detail below; and

[WHEREAS, as a subsidiary of Borrower, __________, the “Company”) will benefit from the making of
the loan(s) to Borrower under the Credit Facility; and]

WHEREAS, the Board of Directors of [Borrower] [Company] (the “Directors”) deems it
advisable and in the best interests of [Borrower] [Company] to execute, deliver and perform its
obligations under those transaction documents described and referred to below.

NOW, THEREFORE, be it

RESOLVED, that the Credit Facility be, and it hereby is, approved; and further

RESOLVED, that the form of Loan and Security Agreement (the “Loan and Security Agreement”),
by and among [Borrower], [Company,] the other Borrowers from time to time party thereto, the
[other] guarantors from time to time party thereto, Agent and the Lenders, as presented to the
Directors, be and it hereby is, approved and the [President, the Chief Executive Officer, Chief
Financial Officer, the Vice President or Treasurer] of [Borrower] [Company] (collectively, the
“Proper Officers”) be, and each of them hereby is, authorized and directed on behalf of
[Borrower] [Company] to execute and deliver to Agent the Loan and Security Agreement, in
substantially the form as presented to the Directors, with such changes as the Proper Officers may
approve, such approval to be conclusively evidenced by execution and delivery thereof; and further

[RESOLVED, that the form of Promissory Note (the “Note”), as presented to the Directors,
be, and it hereby is, approved and the Proper Officers be, and each of them hereby is, authorized
and directed on behalf of Borrower to execute and deliver to Lender one or more promissory Notes,
in substantially the form as presented to the Directors, with such changes as the Proper Officers
may approve, such approval to be conclusively evidenced by execution and delivery thereof; and
further]

[RESOLVED, that the form(s) of [Intellectual Property Security Agreement] [Pledge Agreement] [and]
[Account Control Agreement] [(collectively, the “Security Documents”)] [and the form of the
Preferred Stock Warrant,] [Disbursement Letter,] [Guaranty,] [INCLUDE OTHER DOCUMENTS AS
APPROPRIATE] (together with the Security Documents, the “Ancillary Documents”), each as
presented to the Directors, be, and each of them hereby is, approved and the Proper Officers be,
and each of them hereby is, authorized and directed on behalf of Borrower to execute and deliver to
Agent each of the Ancillary Documents, in substantially the form as presented to the Directors,
with such changes as the

 

 

Proper Officers may approve, such approval to be conclusively evidenced by execution and delivery
thereof; and further]

RESOLVED, that the Proper Officers be, and each of them hereby is, authorized and directed to
execute and deliver any and all other agreements, certificates, security agreements, financing
statements, indemnification agreements, instruments and documents (together with the Loan and
Security Agreement, [and] the Notes [, and the Ancillary Documents], the “Debt Documents”)
and take any and all other further action, in each case, as may be required or which they may deem
appropriate, on behalf of [Borrower] [Company], in connection with the Credit Facility and carrying
into effect the foregoing resolutions, transactions and matters contemplated thereby; and further

RESOLVED, that [Borrower] [Company] is hereby authorized to perform its obligations under the Debt
Documents, [including, without limitation, the borrowing of any advances made under the Credit
Facility and] the granting of any security interest in [Borrower’s] [Company’s] assets contemplated
thereby to secure [Borrower’s] [Company’s] obligations in connection therewith; and further

RESOLVED, that in addition to executing any documents approved in the preceding resolutions, the
Secretary or any Assistant Secretary of [Borrower] [Company] may attest to such Debt Documents, the
signature thereon or the corporate seal of [Borrower] [Company] thereon; and further

RESOLVED, that any actions taken by the Proper Officers prior to the date of these resolutions in
connection with the transactions contemplated by these resolutions are hereby ratified and
approved; and further

RESOLVED, that these resolutions shall be valid and binding upon [Borrower] [Company].

 

 

EXHIBIT C-1

FORM OF LANDLORD CONSENT

[Landlord]

[Address]

[__________, ____]

Ladies and Gentlemen:

     General Electric Capital Corporation (together with its successors and assigns, if any,
“Agent”) and certain other lenders (the “Lenders”) have entered into, or is about
to enter into, a Loan and Security Agreement, dated as of [DATE] (as amended, restated,
supplemented or otherwise modified from time to time, the “Agreement”) with [CUSTOMER NAME]
(“Borrower”) [and __________ (“Company”)], pursuant to which [Borrower] [Company]
has granted, or will grant, to Agent, on behalf of itself and the Lenders, a security interest in
certain assets of [Borrower] [Company], including, without limitation, all of [Borrower’s]
[Company’s] cash, cash equivalents, accounts, books and records, goods, inventory, machinery,
equipment, furniture and trade fixtures (such as equipment bolted to floors), together with all
addition, substitutions, replacements and improvements to, and proceeds, including, insurance
proceeds, of the foregoing, but excluding building fixtures (such as plumbing, lighting and HVAC
systems (collectively, the “Collateral”). Some or all of the Collateral is, or will be,
located at certain premises known as [__________________] in the City or Town of [_____________,
County of _________________________ and State of _______] (“Premises”), and [Borrower]
[Company] occupies the Premises pursuant to a lease, dated as of [DATE], between [Borrower]
[Company], as tenant, and you, [NAME], as [owner/landlord/mortgagee/realty manager] (as amended,
restated, supplemented or otherwise modified from time to time, the “Lease”).

     By your signature below, you hereby agree (and we shall rely on your agreement) that: (i) the
Lease is in full force and effect and you are not aware of any existing defaults thereunder, (ii)
the Collateral is, and shall remain, personal property regardless of the method by which it may be,
or become, affixed to the Premises; (iii) you agree to use your best efforts to provide Agent with
written notice of any default by [Borrower] [Company] under the Lease resulting in a termination of
the Lease (“Default Notice”) and Agent shall have the right, but not the obligation to cure
such default within 15 days following Agent’s receipt of such Default Notice, (iv) your interest in
the Collateral and any proceeds thereof (including, without limitation, proceeds of any insurance
therefor) shall be, and remain, subject and subordinate to the interests of Agent and you agree not
to levy upon any Collateral or to assert any landlord lien, right of distraint or other claim
against the Collateral for any reason; (v) Agent, and its employees and agents, shall have the
right, from time to time, to enter into the Premises for the purpose of inspecting the Collateral;
and (vi) Agent, and its employees and agents, shall have the right, upon any default by [Borrower]
[Company] under the Agreement, to enter into the Premises and to remove or otherwise deal with the
Collateral, including, without limitation, by way of public auction or private sale (provided that,
if Agent conducts a public auction or private sale of the Collateral at the Premises, Agent shall
use reasonable efforts to notify Landlord first and to hold such auction or sale in a manner that
would not unduly disrupt Landlord’s or any other tenant’s use of the Premises). Agent agrees to
repair or reimburse you for any physical damage actually caused to the Premises by Agent, or its
employees or agents, during any such removal or inspection (other than ordinary wear and tear),
provided that it is understood by the parties hereto that Agent shall not be liable for any
diminution in value of the Premises caused by the removal or absence of the Collateral therefrom.
You hereby acknowledge that Agent shall have no obligation to remove or dispose of the Collateral
from the Premises and no action by Agent pursuant to this Consent shall be deemed to be an
assumption by Agent of any obligation under the Lease and, except as provided in the immediately
preceding sentence, Agent shall not have any obligation to you.

 

 

     You hereby acknowledge and agree that [Borrower’s] [Company’s] granting of a security interest
in the Collateral in favor of Agent, on behalf of itself and the Lenders, shall not constitute a
default under the Lease nor permit you to terminate the Lease or re-enter or repossess the Premises
or otherwise be the basis for the exercise of any remedy available to you.

     This Consent and the agreements contained herein shall be binding upon, and shall inure to the
benefit of, any successors and assigns of the parties hereto (including any transferees of the
Premises). This Consent shall terminate upon the indefeasible payment of Borrower’s indebtedness
in full in immediately available funds and the satisfaction in full of Borrower’s [and Company’s]
performance of its obligations under the Agreement and the related documents.

     This Consent and any amendments, waivers, consents or supplements hereto or in connection
herewith may be executed in any number of counterparts and by different parties hereto in separate
counterparts, each of which when so executed and delivered shall be deemed an original, but all
such counterparts together shall constitute but one and the same instrument; signature pages may be
detached from multiple separate counterparts and attached to a single counterpart so that all
signature pages are physically attached to the same document. Delivery of an executed signature
page of this Consent or any delivery contemplated hereby by facsimile or electronic transmission
shall be as effective as delivery of a manually executed counterpart thereof.

 

 

     We appreciate your cooperation in this matter of mutual interest.

	 	 	 	 	 
	 	GENERAL ELECTRIC CAPITAL CORPORATION, as Agent

 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 
	 	General Electric Capital Corporation

c/o GE Healthcare Financial Services, Inc.

Two Bethesda Metro Center, Suite 600

Bethesda, Maryland 20814

Attention: Senior Vice President of Risk — Life Science Finance

Phone: (301) 961-1640

Facsimile: (301) 664-9855

With a copy to:

General Electric Capital Corporation

c/o GE Healthcare Financial Services, Inc.

Two Bethesda Metro Center, Suite 600

Bethesda, Maryland 20814

Attention: General Counsel

Phone: (301) 961-1640

Facsimile: (301) 664-9866

 

	 	 	 	 	 
	 	AGREED TO AND ACCEPTED BY:

[NAME], as [owner/landlord/mortgagee/realty manager]

 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 

Address:

AGREED TO AND ACCEPTED BY:

	 	 	 	 	 
	 	[NAME OF LOAN PARTY]

 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 

Interest in the Premises (check applicable box)

     o Owner

     o Mortgagee

     o Landlord

     o Realty Manager

Address:

 

 

EXHIBIT C-2

FORM OF BAILEE CONSENT

[Letterhead of GE Capital]

_____ ___, 200__

[NAME OF BAILEE]

________________

________________

Dear Sirs:

     Re: [Name of the Loan Party] (the “Company”)

     Please accept this letter as notice that we have entered into or may enter into financing
arrangements with the Company under which the Company has granted to us continuing security
interests in substantially all personal property and assets of the Company and the proceeds
thereof, including, without limitation, certain equipment owned by the Company held by you at the
manufacturing facility (the “Premises”) owned by you and located at [______________](the
“Personal Property”).

     Please acknowledge that as a result of such arrangements, you are holding all of the Personal
Property solely for our benefit and subject only to the terms of this letter and our instructions;
provided, however, that until further written notice from us, you are authorized to use
and/or release any and all of the Personal Property in your possession as directed by the Company
in the ordinary course of business. The foregoing instructions shall continue in effect until we
modify them in writing, which we may unilaterally do without any consent or approval from the
Company. Upon receipt of our instructions, you agree that (a) you will release the Personal
Property only to us or our designee; (b) you will cooperate with us in our efforts to assemble,
sell (whether by public or private sale), take possession of, and remove all of the Personal
Property located at the Premises; (c) you will permit the Personal Property to remain on the
Premises for forty-five (45) days after your receipt of our instructions or at our option, to have
the Personal Property removed from the Premises within a reasonable time, not to exceed forty-five
(45) days after your receipt of our instructions; (d) you will not hinder our actions in enforcing
our liens on the Personal Property; and (e) after receipt of our instructions, you will abide
solely by our instructions with respect to the Personal Property, and not those of the Company.

     You hereby waive and release in our favor: (a) any contractual lien, security interest, charge
or interest and any other lien which you may be entitled to whether by contract, or arising at law
or in equity against any Personal Property; (b) any and all rights granted under any present or
future laws to levy or distrain for rent or any other charges which may be due to you against the
Personal Property; and (c) any and all other claims, liens, rights of offset, deduction,
counterclaim and demands of every kind which you have or may hereafter have against the Personal
Property.

     You agree that (i) you have not and will not commingle the Personal Property with any other
property of a similar kind owned or held by you in any manner such that the Personal Property is
not readily identifiable, (ii) you have not and will not issue any negotiable or non-negotiable
documents or instruments relating to the Personal Property, and (iii) the Personal Property is not
and will not be deemed to be fixtures.

 

 

     Notwithstanding the foregoing, all of your charges of any nature whatsoever shall continue to
be charged to and paid by the Company and we shall not be liable for such charges.

     You hereby authorize us to file at any time such financing statements naming you as the
debtor/bailee, Company as the secured party/bailor, and us as the Company’s assignee, indicating as
the collateral goods of the Company now or hereafter in your custody, control or possession and
proceeds thereof, and including any other information with respect to the Company required under
the Uniform Commercial Code for the sufficiency of such financing statement or for it to be
accepted by the filing office of any applicable jurisdiction (and any amendments or continuations
with respect thereto).

     The arrangement as outlined herein is to continue without modification, until we have given
you written notice to the contrary.

     EACH OF THE PARTIES HERETO HEREBY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF
ACTION BASED UPON OR ARISING OUT OF THIS LETTER.

     Any notice(s) required or desired to be given hereunder shall be directed to the party to be
notified at the address stated herein.

     The terms and conditions contained herein are to be construed and enforced in accordance with
the laws of the State of New York.

     This terms and conditions contained herein shall inure to the benefit of and be binding upon
the parties hereto and their respective successors and permitted assigns.

 

 

The Company has signed below to indicate its consent to and agreement with the foregoing
arrangements, terms and conditions. By your signature below, you hereby agree to be bound by the
terms and conditions of this letter.

	 	 	 	 	 
	 	Very truly yours,

GENERAL ELECTRIC CAPITAL CORPORATION

 	 
	 	By:  	 	 
	 	 	Name:	 	 
	 	 	Title:	Duly Authorized Signatory 	 
	 
	 	General Electric Capital Corporation

c/o GE Healthcare Financial Services, Inc.

Two Bethesda Metro Center, Suite 600

Bethesda, Maryland 20814

Attention: Senior Vice President of Risk — Life Science Finance

Phone: (301) 961-1640

Facsimile: (301) 664-9855

With a copy to:

General Electric Capital Corporation

c/o GE Healthcare Financial Services, Inc.

Two Bethesda Metro Center, Suite 600

Bethesda, Maryland 20814

Attention: General Counsel

Phone: (301) 961-1640

Facsimile: (301) 664-9866

 

Agreed to:

[NAME OF LOAN PARTY]

	 	 	 	 	 	 	 

	By:
	 	 	 	 
	 

	 	Name:	 	 	 	 
	 

	 	Title:	 	 	 	 
	 

	 	Address:	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 

[NAME OF BAILEE]

	 	 	 	 	 	 	 

	By:
	 	 	 	 
	 

	 	Name:	 	 	 	 
	 

	 	Title:	 	 	 	 
	 

	 	Address:	 	 	 	 
	 	 	 	 	 

 

 

EXHIBIT D

COMPLIANCE CERTIFICATE

[DATE]

          Reference is made to the Loan and Security Agreement, dated as of February 8, 2011 (as
amended, restated, supplemented or otherwise modified from time to time, the “Agreement”),
among Oncothyreon Inc., a Delaware corporation (the “Borrower”), the guarantors from time
to time party thereto, General Electric Capital Corporation, a Delaware corporation
(“GECC”), in its capacity as agent (in such capacity, together with its successors and
assigns, in such capacity, the “Agent”) and lender, and the other lenders signatory thereto
(GECC and such other lenders, the “Lenders”). Capitalized terms used but not defined
herein are used with the meanings assigned to such terms in the Agreement.

The undersigned officer hereby certifies on behalf of the Borrower as of the date hereof, in
her/his capacity as the [TITLE] of the Borrower and not in her/his personal capacity, as follows:

(i) I am the duly elected, qualified and acting [TITLE] of Borrower;

(ii) attached hereto as Exhibit A are [the monthly financial statements]/[annual audited
financial statements]/[quarterly financial statements] as required under Section 6.3 of the
Agreement and that such financial statements are prepared in accordance with GAAP (subject, in the
case of unaudited financial statements, to the absence of footnotes and normal year-end audit
adjustments);

     (iii) no Default or Event of Default has occurred under the Agreement which has not been
previously disclosed, in writing, to Agent [except as described below — only include if a Default
or Event of Default has occurred and describe if applicable];

(iv) all representations and warranties of the Loan Parties stated in the Debt Documents are true
and correct in all material respects on and as of the date hereof, except to the extent such
representations and warranties expressly relate to an earlier date, in which case such
representations and warranties were true and correct in all material respects on and as of such
earlier date (except that in each case such materiality qualifiers shall not be applicable to any
representation or warranty that already is expressly qualified or modified by materiality in the
text thereof); and

(v) no Loan Party owns any Margin Stock as of the date hereof.

IN WITNESS WHEREOF, the undersigned has executed this Certificate as of the first date written
above

	 	 	 	 	 
	 	 	 
	 	  	  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 

 

 

	 	 	 	 	 

EXHIBIT E

AUTOMATIC PAYMENT AUTHORIZATION AGREEMENT

Introduction

When you use the automatic payment service, the payment is automatically made by electronic
transfer directly from your bank account at the financial institution specified below. An
“authorized check signer” must complete, sign and submit one copy of this Authorization Agreement.

Authorization Agreement for Automatic Payment Service (ACH Debits)

1. Oncothyreon Inc. (“Borrower”) hereby authorizes General Electric Capital Corporation
(“Agent”) to initiate debit entries for amounts due under the Loan and Security Agreement,
dated as of February 8, 2011 (as amended, restated, supplemented or otherwise modified from time to
time, the “Loan Agreement”), among Borrower, the guarantors form time to time party
thereto, Agent and the lenders from time to time party thereto. Capitalized terms used herein but
not defined herein are used herein as defined in the Loan Agreement.

2. Borrower understands that the payment of all Obligations are solely its responsibility. If
payment is not satisfied due to account closure, insufficient funds, or cancellation of any
required automated payment services, Borrower agrees to remit payment plus any applicable late
charges as set forth in the Loan Agreement.

3. It is incumbent upon Borrower to give written notice to Agent of any changes to this
Authorization Agreement or the below referenced bank account information 10 days prior to payment
date. Borrower may revoke this Authorization Agreement by giving 10 days written notice to Agent
unless otherwise stipulated in the Loan Agreement.

4. If the account identified below is a joint account, all of the account holders must sign this
Authorization Agreement.

Account

Provide the following information regarding the account to be debited.

	 	 	 	 	 	 	 

	  Account type: o Checking  o Savings

	 	 	 	 	 	 	 

	 

	 	Financial Institution: 	 	 	 	 
	 

	 	 	 	 

	 	 

	 	 	 	 	 	 	 

	 

	 	Name of Account: 	 	 	 	 
	 

	 	 	 	 

	 	 

	 	 	 	 	 	 	 

	 

	 	Address of Financial Institution: 	 	 	 	 
	 

	 	  	 	 

	 	 

	 	 	 	 	 	 	 

	 

	 	City/State/Zip:	 	 	 	 
	 

	 	 	 	 

	 	 

	 	 	 	 	 	 	 

	 

	 	Account #:	 	 	 	 
	 

	 	 	 	 

	 	 

	 	 	 	 	 	 	 

	 

	 	ABA Routing #:	 	 	 	 
	 

	 	 	 	 

	 	 

	 	 	 	 	 
	 	ONCOTHYREON INC.

 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 

 

 

	 	 	 	 	 
	 	[INSERT NAME OF EACH JOINT-ACCOUNT HOLDER, IF ANY]

 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 

 

 

	 	 	 	 	 

EXHIBIT F

FORM OF WARRANT

[See Exhibit 10.3]

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