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Exhibit 10.2  

 
 

AMENDMENT NO. 1 TO
  ISIS PHARMACEUTICALS, INC.
  2000 EMPLOYEE STOCK PURCHASE PLAN    
    

        This Amendment No. 1 to the Isis Pharmaceuticals, Inc. 2000 Employee Stock Purchase Plan (the "Amendment"), is effective as of September 23,
2003. 

	A.
	WHEREAS,
the Board of Directors of Isis wish to amend the Isis Pharmaceuticals, Inc. 2000 Employee Stock Purchase Plan (the "ESPP"), as more fully described below. 

        NOW
THEREFORE, the Board of Directors hereby approves the amendment of the ESPP as follows: 

        All
capitalized terms not otherwise defined herein, will have the meanings ascribed to them in the ESPP. 

ARTICLE 1. AMENDMENT  

        1.1    Amendment and Restatement of Section 3(a).    Section 3(a) of the ESPP is hereby amended,
restated and replaced in its entirety by the following language: 

        "(a)
Subject to the provisions of Section 12 relating to adjustments upon changes in stock, the stock that may be sold pursuant to rights granted under the Plan shall not exceed
in the aggregate two hundred thousand (200,000) shares of Common Stock (the "Reserved Shares"). Through the first nine (9) anniversaries of the Effective Date of the Plan, on January 1
of each year the number of Reserved Shares will be increased automatically by the lesser of (i) one percent (1%) of the total number of shares of Common Stock outstanding on such date or
(ii) two hundred thousand (200,000) shares. If any right granted under the Plan shall for any reason terminate without having been exercised, the Common Stock not purchased under such right
shall again become available for the Plan." 

        1.2   Except
as specifically provided in this Amendment, all other terms and conditions of the ESPP will remain in full force and effect. 

1

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AMENDMENT NO. 1 TO ISIS PHARMACEUTICALS, INC. 2000 EMPLOYEE STOCK PURCHASE PLAN<Page>

                                                                     Exhibit 4.3

                        VASO ACTIVE PHARMACEUTICALS, INC.

                                       AND

                        KASHNER DAVIDSON SECURITIES CORP.

                                REPRESENTATIVE'S
                                WARRANT AGREEMENT

                      DATED AS OF ___________________, 2003

================================================================================

<Page>

          REPRESENTATIVE'S WARRANT AGREEMENT dated as of __________, 2003
between VASO ACTIVE PHARMACEUTICALS, INC., a Delaware corporation (the
"Company") and KASHNER DAVIDSON SECURITIES CORP. (the "Representative").

                              W I T N E S S E T H:

          WHEREAS, the Company proposes to issue to the Representative warrants
to purchase up to an aggregate of 130,000 shares of Class A Common Stock,
$0.0001 par value, of the Company (the "Warrants"); and

          WHEREAS, the Representative has agreed pursuant to the underwriting
agreement (the "Underwriting Agreement") dated as of the date hereof between the
Company and the several Underwriters listed therein to act as the Representative
in connection with the Company's proposed public offering of up to 1,300,000
shares of Class A Common Stock at a public offering price of $5.00 per share
(the "Public Offering"); and

          WHEREAS, the Warrants to be issued pursuant to this Agreement will be
issued on the Closing Date (as such term is defined in the Underwriting
Agreement) by the Company to the Representative in consideration for, and as
part of the Representative's compensation in connection with, the Representative
acting as the Representative pursuant to the Underwriting Agreement;

          NOW, THEREFORE, in consideration of the premises, the payment by the
Representative to the Company of an aggregate one hundred dollars ($100.00), the
agreements herein set forth and other good and valuable consideration, hereby
acknowledged, the parties hereto agree as follows:

          1.    GRANT. The Representative (or its designees) (together, the
"Holders" and each a "Holder") is hereby granted the right to purchase, at any
time from __________, 2004, until 5:30 P.M., New York time, on __________, 2008,
up to an aggregate of 130,000 shares of

<Page>

Class A Common Stock at an initial exercise price (subject to adjustment as
provided in SECTION 8 hereof) of $6.00 per share of Class A Common Stock. Except
as set forth herein, the shares of Class A Common Stock issuable upon exercise
of the Warrants are in all respects identical to the shares of Class A Common
Stock being purchased by the Underwriters for resale to the public pursuant to
the terms and provisions of the Underwriting Agreement.

          2.    WARRANT CERTIFICATES. The warrant certificates (the "Warrant
Certificates") delivered and to be delivered pursuant to this Agreement shall be
in the form set forth in Exhibit A, attached hereto and made a part hereof, with
such appropriate insertions, omissions, substitutions, and other variations as
required or permitted by this Agreement.

          3.    EXERCISE OF WARRANT.

          Section 3.1   METHOD OF EXERCISE. The Warrants initially are
exercisable at an aggregate initial exercise price (subject to adjustment as
provided in SECTION 8 hereof) per share of Class A Common Stock set forth in
SECTION 6 hereof payable by certified or official bank check in New York
Clearing House funds, subject to adjustment as provided in SECTION 8 hereof.
Upon surrender of a Warrant Certificate with the annexed Form of Election to
Purchase duly executed, together with payment of the Exercise Price (as
hereinafter defined) for the shares of Class A Common Stock purchased at the
Company's principal executive offices in Danvers, Massachusetts (presently
located at 99 Rosewood Drive, Suite 260, Danvers, Massachusetts 01923) the
registered holder of a Warrant Certificate shall be entitled to receive a
certificate or certificates for the shares of Class A Common Stock so purchased.
The purchase rights represented by each Warrant Certificate are exercisable at
the option of the Holder thereof, in whole or in part (but not as to fractional
shares of the Class A Common Stock). The Warrants may be exercised to purchase
all or part of the shares of Class A Common Stock. In the case of the purchase
of less than all the shares of Class A Common Stock under any Warrant
Certificate,

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the Company shall cancel said Warrant Certificate upon the surrender thereof and
shall execute and deliver a new Warrant Certificate of like tenor for the
balance of the shares of Class A Common Stock purchasable thereunder.

          Section 3.2   EXERCISE BY SURRENDER OF WARRANT. In addition to the
method of payment set forth in SECTION 3.1 and in lieu of any cash payment
required thereunder, the Holder(s) shall have the right at any time and from
time to time to exercise the Warrants in full or in part by surrendering the
Warrant Certificate in the manner specified in SECTION 3.1 hereof. The number of
shares of Class A Common Stock to be issued pursuant to this SECTION 3.2 shall
be equal to the difference between (a) the number of shares of Class A Common
Stock in respect of which the Warrants are exercised and (b) a fraction, the
numerator of which shall be the number of shares of Class A Common Stock in
respect of which the Warrants are exercised multiplied by the Exercise Price and
the denominator of which shall be the Market Price (as defined in SECTION 3.3
hereof) of the shares of Class A Common Stock. Solely for the purposes of this
paragraph, Market Price shall be calculated either (i) on the date on which the
form of election attached hereto is deemed to have been sent to the Company
pursuant to Section 13 hereof ("Notice Date") or (ii) as the average of the
Market Prices for each of the five trading days preceding the Notice Date,
whichever of (i) or (ii) is greater.

          Section 3.3   DEFINITION OF MARKET PRICE. As used herein, the phrase
"Market Price" at any date shall be deemed to be the last reported sale price,
or, in case no such reported sale takes place on such day, the average of the
last reported sale prices for the last three (3) trading days, in either case as
officially reported by the principal securities exchange on which the Class A
Common Stock is listed or admitted to trading or by the Nasdaq SmallCap Market
("Nasdaq SmallCap") or by the National Association of Securities Dealers
Automated Quotation System ("Nasdaq"), or, if the Class A Common Stock is not
listed or admitted to trading on any national

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<Page>

securities exchange or quoted by Nasdaq, the average closing bid price as
furnished by the National Association of Securities Dealers, Inc. ("NASD")
through Nasdaq or similar organization if Nasdaq is no longer reporting such
information, or if the Class A Common Stock is not quoted on Nasdaq, as
determined in good faith (using customary valuation methods) by resolution of
the members of the Board of Directors of the Company, based on the best
information available to it.

          4.    ISSUANCE OF CERTIFICATES. Upon the exercise of the Warrants, the
issuance of certificates for shares of Class A Common Stock shall be made
forthwith (and in any event within five (5) business days thereafter) without
charge to the Holder thereof including, without limitation, any tax which may be
payable in respect of the issuance thereof, and such certificates shall (subject
to the provisions of SECTIONS 5 and 7 hereof) be issued in the name of, or in
such names as may be directed by, the Holder thereof; provided, however, that
the Company shall not be required to pay any tax which may be payable in respect
of any transfer involved in the issuance and delivery of any such certificates
in a name other than that of the Holder, and the Company shall not be required
to issue or deliver such certificates unless or until the person or persons
requesting the issuance thereof shall have paid to the Company the amount of
such tax or shall have established to the satisfaction of the Company that such
tax has been paid.

          The Warrant Certificates and the certificates representing the shares
of Class A Common Stock shall be executed on behalf of the Company by the manual
or facsimile signature of the then Chairman or Vice Chairman of the Board of
Directors or President or Vice President of the Company. Warrant Certificates
shall be dated the date of execution by the Company upon initial issuance,
division, exchange, substitution or transfer. Certificates representing the
shares of Class A Common Stock shall be dated as of the Notice Date (regardless
of when executed or delivered) and dividend bearing securities so issued shall
accrue dividends from the Notice Date.

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          5.    RESTRICTION ON TRANSFER OF WARRANTS. The Holder of a Warrant
Certificate, by his, her or its acceptance thereof, covenants and agrees that
the Warrants are being acquired as an investment and not with a view to the
distribution thereof; that the Warrants may not be sold, transferred, assigned,
hypothecated or otherwise disposed of, in whole or in part, for a period of one
(1) year from the date hereof, except to officers of the Representative.

          6.    EXERCISE PRICE.

          Section 6.1   INITIAL AND ADJUSTED EXERCISE PRICE. Except as otherwise
provided in SECTION 8 hereof, the initial exercise price of each Warrant shall
be $6.00 per share of Class A Common Stock. The adjusted exercise price shall be
the price which shall result from time to time from any and all adjustments of
the initial exercise price in accordance with the provisions of SECTION 8
hereof. Any transfer of a Warrant shall constitute an automatic transfer and
assignment of the registration rights set forth in SECTION 7 hereof with respect
to the Securities or other securities, properties or rights underlying the
Warrants.

          Section 6.2   EXERCISE PRICE. The term "Exercise Price" herein shall
mean the initial exercise price or the adjusted exercise price, depending upon
the context or unless otherwise specified.

          7.    REGISTRATION RIGHTS.

          Section 7.1   REGISTRATION UNDER THE SECURITIES ACT OF 1933. The
Warrants and the shares of Class A Common Stock issuable upon exercise of the
Warrants (collectively, the "Warrant Securities") have not been registered under
the Securities Act of 1933, as amended (the "Act") and the certificates
representing the Warrant Securities or any other evidence thereof shall bear the
following legend:

          The securities represented by this certificate have not been
          registered under the Securities Act of 1933, as amended
          ("Act"), and may not be offered or sold except pursuant to
          (i) an effective

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          registration statement under the Act, (ii) to the extent
          applicable, Rule 144 under the Act (or any similar rule
          under such Act relating to the disposition of securities),
          or (iii) an opinion of counsel, if such opinion shall be
          reasonably satisfactory to counsel to the issuer, that an
          exemption from registration under such Act is available.

          Section 7.2   PIGGYBACK REGISTRATION. If, at any time commencing after
the effective date of the Registration Statement and EXPIRING seven (7) years
thereafter, the Company proposes to register any of its securities under the Act
(other than pursuant to Form S-4, Form S-8 or a comparable registration
statement) it will give written notice by registered mail, at least thirty (30)
days prior to the filing of each such registration statement, to the
Representative and to all other Holders of the Warrant Securities of its
intention to do so. If the Representative or other Holders of the Warrant
Securities notify the Company within twenty (20) business days after receipt of
any such notice of its or their desire to include any such securities in such
proposed registration statement, the Company shall afford the Representative and
such Holders of the Warrant Securities the opportunity to have any such Warrant
Securities registered under such registration statement (sometimes referred to
herein as "Piggyback Registration").

          If a Piggyback Registration is an underwritten primary registration on
behalf of the Company, and the managing underwriters advise the Company in
writing that in their opinion the number of securities requested to be included
in such registration exceeds the number which can be sold in such offering, the
Company will include in such registration (i) first, the securities the Company
proposes to sell, (ii) second, the Warrant Securities requested to be included
in such registration, pro rata among the Holders of such Warrant Securities on
the basis of the number of shares requested by such Holders, and (iii) third,
other securities requested to be included in such registration.

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<Page>

          If a Piggyback Registration is an underwritten secondary registration
on behalf of holders of the Company's Class A Common Stock, and the managing
underwriters advise the Company in writing that in their opinion the number of
securities requested to be included in such registration exceeds the number
which can be sold in such offering, the Company will include in such
registration (i) first, the securities requested to be included therein by the
holders requesting such registration pursuant to a demand registration right and
the Warrant Securities requested to be included by Holders under Piggyback
Registration rights hereunder on a pro rata basis among such holders requesting
inclusion in such registration, and (ii) second, other securities requested to
be included in such registration.

          Notwithstanding the provisions of this SECTION 7.2, the Company shall
have the right at any time after it shall have given written notice pursuant to
this SECTION 7.2 (irrespective of whether a written request for inclusion of any
such securities shall have been made) to elect not to file any such proposed
registration statement, or to withdraw the same after the filing but prior to
the effective date thereof.

          Section 7.3   DEMAND REGISTRATION.

          (a)   At any time commencing after the effective date of the
Registration Statement and expiring five (5) years thereafter, the Holders of
the Warrant Securities representing a Majority (as hereinafter defined) of such
securities shall have the right (which right is in addition to the registration
rights under SECTION 7.2 hereof), exercisable by written notice to the Company,
to have the Company prepare and file with the Securities and Exchange Commission
(the "Commission"), on one occasion, a registration statement and such other
documents, including a prospectus, as may be necessary in the opinion of both
counsel for the Company and counsel for the Representative and Holders, in order
to comply with the provisions of the Act, so as to permit a public offering and
sale of their respective Warrant Securities for six

                                        7
<Page>

(6) consecutive months by such Holders and any other Holders of the Warrant
Securities who notify the Company within ten (10) days after receiving notice
from the Company of such request.

          (b)   The Company covenants and agrees to give written notice of any
registration request under this SECTION 7.3 by any Holder or Holders to all
other registered Holders of the Warrant Securities within ten (10) days from the
date of the receipt of any such registration request.

          Section 7.4   COVENANTS OF THE COMPANY WITH RESPECT TO REGISTRATION.
In connection with any registration under SECTION 7.2 or 7.3 hereof, the Company
covenants and agrees as follows:

          (a)   The Company shall use its best efforts to file a registration
statement within forty five (45) days of receipt of any demand therefor, shall
use its best efforts to have any registration statements declared effective at
the earliest possible time, and shall furnish each Holder desiring to sell
Warrant Securities such number of prospectuses as shall reasonably be requested.

          (b)   The Company shall pay all costs (excluding fees and expenses of
Holder(s)' counsel and any underwriting or selling commissions), fees and
expenses in connection with all registration statements filed pursuant to
SECTION 7.2 including, without limitation, the Company's legal and accounting
fees, printing expenses, blue sky fees and expenses.

          (c)   The Company will take all necessary action which may be required
in qualifying or registering the Warrant Securities included in a registration
statement for offering and sale under the securities or blue sky laws of such
states as reasonably are requested by the Holder(s), provided that the Company
shall not be obligated to execute or file any general

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<Page>

consent to service of process or to qualify as a foreign corporation to do
business under the laws of any such jurisdiction.

          (d)   The Company shall indemnify the Holder(s) of the Warrant
Securities to be sold pursuant to any registration statement and each person, if
any, who controls such Holders within the meaning of SECTION 15 of the Act or
SECTION 20(a) of the Securities Exchange Act of 1934, as amended ("Exchange
Act"), against all loss, claim, damage, expense or liability (including all
expenses reasonably incurred in investigating, preparing or defending against
any claim whatsoever) to which any of them may become subject under the Act, the
Exchange Act or otherwise, arising from such registration statement but only to
the same extent and with the same effect as the provisions pursuant to which the
Company has agreed to indemnify each of the Underwriters contained in SECTION 7
of the Underwriting Agreement.

          (e)   The Holder(s) of the Warrant Securities to be sold pursuant to a
registration statement, and their successors and assigns, shall severally, and
not jointly, indemnify the Company, its officers and directors and each person,
if any, who controls the Company within the meaning of SECTION 15 of the Act or
SECTION 20(a) of the Exchange Act, against all loss, claim, damage, expense or
liability (including all expenses reasonably incurred in investigating,
preparing or defending against any claim whatsoever) to which they may become
subject under the Act, the Exchange Act or otherwise, arising from information
furnished by or on behalf of such Holders, or their successors or assigns, for
specific inclusion in such registration statement to the same extent and with
the same effect as the provisions contained in SECTION 7 of the Underwriting
Agreement pursuant to which the Underwriters have agreed to indemnify the
Company.

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          (f)   Nothing contained in this Agreement shall be construed as
requiring the Holder(s) to exercise their Warrants prior to the initial filing
of any registration statement or the effectiveness thereof.

          (g)   The Company shall not permit the inclusion of any securities
other than the Warrant Securities to be included in any registration statement
filed pursuant to SECTION 7.3 hereof, or permit any other registration statement
to be or remain effective during the effectiveness of a registration statement
filed pursuant to SECTION 7.3 hereof (other than (i) shelf registrations
effective prior thereto and (ii) registrations on Form S-4 or S-8), without the
prior written consent of the Holders of the Warrants and Warrant Securities
representing a Majority of such securities.

          (h)   The Company shall furnish to each Holder participating in the
offering and to each underwriter, if any, a signed counterpart, addressed to
such Holder or underwriter, of (i) an opinion of counsel to the Company, dated
the effective date of such registration statement (and, if such registration
includes an underwritten public offering, an opinion dated the date of the
closing under the underwriting agreement) relating to the due incorporation of
the Company, the validity of the shares being issued, the due execution and
delivery of the underwriting agreement and (ii) if such registration includes an
underwritten public offering, a "cold comfort" letter dated the effective date
of such registration statement and a letter dated the date of the closing under
the underwriting agreement signed by the independent public accountants who have
issued a report on the Company's financial statements included in such
registration statement, covering substantially the same matters with respect to
such registration statement (and the prospectus included therein) and, with
respect to events subsequent to the date of such financial statements, as are
customarily covered in accountants' letters delivered to underwriters in
underwritten public offerings of securities.

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          (i)   The Company shall as soon as practicable after the effective
date of the registration statement, and in any event within 15 months
thereafter, make "generally available to its security holders" (within the
meaning of Rule 158 under the Act) an earnings statement (which need not be
audited) complying with SECTION 11(a) of the Act and covering a period of at
least 12 consecutive months beginning after the effective date of the
registration statement.

          (j)   The Company shall deliver promptly to each Holder participating
in the offering requesting the correspondence and memoranda described below and
to the managing underwriters, copies of all correspondence between the
Commission and the Company, its counsel or auditors and all memoranda relating
to discussions with the Commission or its staff with respect to the registration
statement and permit each Holder and underwriter to do such investigation, upon
reasonable advance notice, with respect to information contained in or omitted
from the registration statement as it deems reasonably necessary to comply with
applicable securities laws or rules of the NASD. Such investigation shall
include access to books, records and properties and opportunities to discuss the
business of the Company with its officers and independent auditors, all to such
reasonable extent and at such reasonable times and as often as any such Holder
or underwriter shall reasonably request.

          (k)   The Company shall enter into an underwriting agreement with the
managing underwriters selected for such underwriting by Holders holding a
Majority of the Warrant Securities requested pursuant to SECTION 7.3(a) to be
included in such underwriting, which may be the Representative. Such agreement
shall be reasonably satisfactory in form and substance to the Company, each
Holder and such managing underwriter(s), and shall contain such representations,
warranties and covenants by the Company and such other terms as are customarily
contained in agreements of that type used by the managing underwriter(s). The
Holders shall be parties to any underwriting agreement relating to an
underwritten sale of their

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Warrant Securities whether pursuant to SECTION 7.2 or SECTION 7.3(a) and may, at
their option, require that any or all of the representations, warranties and
covenants of the Company to or for the benefit of such underwriter(s) shall also
be made to and for the benefit of such Holders. Such Holders shall not be
required to make any representations or warranties to or agreements with the
Company or the underwriter(s) except as they may relate to such Holders and
their intended methods of distribution.

          (l)   For purposes of this Agreement, the term "Majority" in reference
to the Holders of Warrant Securities, shall mean in excess of fifty percent
(50%) of the then outstanding Warrant Securities (assuming the exercise of all
of the Warrants) that (i) are not held by the Company, an affiliate, officer,
creditor, employee or agent thereof or any of their respective affiliates,
members of their family, persons acting as nominees or in conjunction therewith
and (ii) have not been resold to the public pursuant to a registration statement
filed with the Commission under the Act.

          8.    ADJUSTMENTS TO EXERCISE PRICE AND NUMBER OF SECURITIES.

          Section 8.1   SUBDIVISION AND COMBINATION. In case the Company shall
at any time subdivide or combine the outstanding shares of Class A Common Stock,
the Exercise Price shall forthwith be proportionately decreased in the case of
subdivision or increased in the case of combination.

          Section 8.2   STOCK DIVIDENDS AND DISTRIBUTIONS. In case the Company
shall pay a dividend in, or make a distribution of, shares of Class A Common
Stock or of the Company's capital stock convertible into Class A Common Stock,
the Exercise Price shall forthwith be proportionately decreased. An adjustment
made pursuant to this SECTION 8.2 shall be made as of the record date for the
subject stock dividend or distribution.

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          Section 8.3   ADJUSTMENT IN NUMBER OF SECURITIES. Upon each adjustment
of the Exercise Price pursuant to the provisions of this SECTION 8, the number
of Class A Common Stock issuable upon the exercise at the adjusted exercise
price of each Warrant shall be adjusted to the nearest full amount by
multiplying a number equal to the Exercise Price in effect immediately prior to
such adjustment by the number of Class A Common Stock issuable upon exercise of
the Warrants immediately prior to such adjustment and dividing the product so
obtained by the adjusted Exercise Price.

          Section 8.4   DEFINITION OF CLASS A COMMON STOCK. For the purpose of
this Agreement, the term "Class A Common Stock" shall mean (i) the class of
stock designated as Class A Common Stock in the Certificate of Incorporation of
the Company as may be amended as of the date hereof, or (ii) any other class of
stock resulting from successive changes or reclassifications of such Class A
Common Stock consisting solely of changes in par value, or from par value to no
par value, or from no par value to par value.

          Section 8.5   MERGER OR CONSOLIDATION. In case of any consolidation of
the Company with, or merger of the Company with, or merger of the Company into,
another corporation (other than a consolidation or merger which does not result
in any reclassification or change of the outstanding Class A Common Stock), the
corporation formed by such consolidation or merger shall execute and deliver to
the Holder a supplemental warrant agreement providing that the holder of each
Warrant then outstanding or to be outstanding shall have the right thereafter
(until the expiration of such Warrant) to receive, upon exercise of such
Warrant, the kind and amount of shares of stock and other securities and
property receivable upon such consolidation or merger, by a holder of the number
of securities of the Company for which such Warrant might have been exercised
immediately prior to such consolidation, merger, sale or transfer. Such
supplemental warrant agreement shall provide for adjustments which shall be
identical to the

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adjustments provided in SECTION 8. The above provision of this subsection shall
similarly apply to successive consolidations or mergers.

          Section 8.6   NO ADJUSTMENT OF EXERCISE PRICE IN CERTAIN CASES. No
adjustment of the Exercise Price shall be made if the amount of said adjustment
shall be less than two cents (2) per Warrant Security, provided, however, that
in such case any adjustment that would otherwise be required then to be made
shall be carried forward and shall be made at the time of and together with the
next subsequent adjustment which, together with any adjustment so carried
forward, shall amount to at least two cents ($.02) per Warrant Security.

          9.    EXCHANGE AND REPLACEMENT OF WARRANT CERTIFICATES. Each Warrant
Certificate is exchangeable without expense, upon the surrender thereof by the
registered Holder at the principal executive office of the Company, for a new
Warrant Certificate of like tenor and date representing in the aggregate the
right to purchase the same number of Warrant Securities in such denominations as
shall be designated by the Holder thereof at the time of such surrender.

          Upon receipt by the Company of evidence reasonably satisfactory to it
of the loss, theft, destruction or mutilation of any Warrant Certificate, and,
in case of loss, theft or destruction, of indemnity or security reasonably
satisfactory to it, and reimbursement to the Company of all reasonable expenses
incidental thereto, and upon surrender and cancellation of the Warrants, if
mutilated, the Company will make and deliver a new Warrant Certificate of like
tenor, in lieu thereof.

          10.   ELIMINATION OF FRACTIONAL INTERESTS. The Company shall not be
required to issue certificates representing fractions of shares of Class A
Common Stock upon the exercise of the Warrants, nor shall it be required to
issue scrip or pay cash in lieu of fractional interests, it being the intent of
the parties that all fractional interests shall be eliminated by rounding any

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fraction up to the nearest whole number of shares of Class A Common Stock or
other securities, properties or rights.

          11.   RESERVATION AND LISTING OF SECURITIES. The Company shall at all
times reserve and keep available out of its authorized shares of Class A Common
Stock, solely for the purpose of issuance upon the exercise of the Warrants,
such number of shares of Class A Common Stock or other securities, properties or
rights as shall be issuable upon the exercise thereof. The Company covenants and
agrees that, upon exercise of the Warrants and payment of the Exercise Price
therefor, all shares of Class A Common Stock issuable upon such exercise shall
be duly and validly issued, fully paid, non-assessable and not subject to the
preemptive rights of any stockholder.

          12.   NOTICES TO WARRANT HOLDERS. Nothing contained in this Agreement
shall be construed as conferring upon the Holders the right to vote or to
consent or to receive notice as a stockholder in respect of any meetings of
stockholders for the election of directors or any other matter, or as having any
rights whatsoever as a stockholder of the Company. If, however, at any time
prior to the expiration of the Warrants and their exercise, any of the following
events shall occur:

                    (a)    the Company shall take a record of the holders of its
          shares of Class A Common Stock for the purpose of entitling them to
          receive a dividend or distribution payable otherwise than in cash, or
          a cash dividend or distribution payable otherwise than out of current
          or retained earnings or capital surplus (in accordance with applicable
          law), as indicated by the accounting treatment of such dividend or
          distribution on the books of the Company; or

                    (b)    the Company shall offer to all the holders of its
          Class A Common Stock any additional shares of capital stock of the
          Company or

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<Page>

          securities convertible into or exchangeable for shares of capital
          stock of the Company, or any option, right or warrant to subscribe
          therefor; or

                    (c)    a dissolution, liquidation or winding up of the
          Company (other than in connection with a consolidation or merger) or a
          sale of all or substantially all of its property, assets and business
          as an entirety shall be proposed;

then, in any one or more of said events, the Company shall give written notice
of such event at least fifteen (15) days prior to the date fixed as a record
date or the date of closing the transfer books for the determination of the
stockholders entitled to such dividend, distribution, convertible or
exchangeable securities or subscription rights, or entitled to vote on such
proposed dissolution, liquidation, winding up or sale. Such notice shall specify
such record date or the date of closing the transfer books, as the case may be.
Failure to give such notice or any defect therein shall not affect the validity
of any action taken in connection with the declaration or payment of any such
dividend, or the issuance of any convertible or exchangeable securities, or
subscription rights, options or warrants, or any proposed dissolution,
liquidation, winding up or sale.

          13.   NOTICES.

          All notices, requests, consents and other communications hereunder
shall be in writing and shall be deemed to have been duly made and sent when
delivered, or mailed by registered or certified mail, return receipt requested
or by Federal Express or other recognized overnight courier:

                    (a)    If to the registered Holder of the Warrants, to the
          address of such Holder as shown on the books of the Company; or

                                       16
<Page>

                    (b)    If to the Company, to the address set forth in
          SECTION 3 hereof or to such other address as the Company may designate
          by notice to the Holders.

          14.   SUPPLEMENTS AND AMENDMENTS. The Company and the Representative
may from time to time supplement or amend this Agreement without the approval of
any Holders of Warrant Certificates (other than the Representative) in order to
cure any ambiguity, to correct or supplement any provision contained herein
which may be defective or inconsistent with any provisions herein, or to make
any other provisions in regard to matters or questions arising hereunder which
the Company and the Representative may deem necessary or desirable and which the
Company and the Representative deem shall not adversely affect the interests of
the Holders of Warrant Certificates.

          15.   SUCCESSORS. All the covenants and provisions of this Agreement
shall be binding upon and inure to the benefit of the Company, the Holders and
their respective successors and assigns hereunder.

          16.   TERMINATION. This Agreement shall terminate at the close of
business on __________, 2008. Notwithstanding the foregoing, the indemnification
provisions of SECTION 7 shall survive such termination until the close of
business on __________, 2014.

          17.   GOVERNING LAW; SUBMISSION TO JURISDICTION. This Agreement and
each Warrant Certificate issued hereunder shall be deemed to be a contract made
under the laws of the State of New York and for all purposes shall be construed
in accordance with the laws of said State without giving effect to the rules of
said State governing the conflicts of laws.

          The Company, the Representative and the Holders hereby agree that any
action, proceeding or claim against it arising out of, or relating in any way
to, this Agreement shall be brought and enforced in the courts of the State of
New York or of the United States of America

                                       17
<Page>

for the Southern District of New York, and irrevocably submits to such
jurisdiction, which jurisdiction shall be exclusive. The Company, the
Representative and the Holders hereby irrevocably waive any objection to such
exclusive jurisdiction or inconvenient forum. Any such process or summons to be
served upon any of the Company, the Representative and the Holders (at the
option of the party bringing such action, proceeding or claim) may be served by
transmitting a copy thereof, by registered or certified mail, return receipt
requested, postage prepaid, addressed to it at the address set forth in SECTION
14 hereof. Such mailing shall be deemed personal service and shall be legal and
binding upon the party so served in any action, proceeding or claim. The
Company, the Representative and the Holders agree that the prevailing party(ies)
in any such action or proceeding shall be entitled to recover from the other
party(ies) all of its/their reasonable legal costs and expenses relating to such
action or proceeding and/or incurred in connection with the preparation
therefore.

          18.   ENTIRE AGREEMENT; MODIFICATION. This Agreement (including the
Underwriting Agreement to the extent portions thereof are referred to herein)
contains the entire understanding between the parties hereto with respect to the
subject matter hereof and may not be modified or amended except by a writing
duly signed by the party against whom enforcement of the modification or
amendment is sought.

          19.   SEVERABILITY. If any provision of this Agreement shall be held
to be invalid or unenforceable, such invalidity or unenforceability shall not
affect any other provision of this Agreement.

          20.   CAPTIONS. The caption headings of the Sections of this Agreement
are for convenience of reference only and are not intended, nor should they be
construed as, a part of this Agreement and shall be given no substantive effect.

                                       18
<Page>

          21.   BENEFITS OF THIS AGREEMENT. Nothing in this Agreement shall be
construed to give to any person or corporation other than the Company and the
Representative and any other registered Holder(s) of the Warrant Securities any
legal or equitable right, remedy or claim under this Agreement; and this
Agreement shall be for the sole benefit of the Company and the Representative
and any other registered Holders of Warrant Securities.

          22.   COUNTERPARTS. This Agreement may be executed in any number of
counterparts and each of such counterparts shall for all purposes be deemed to
be an original, and such counterparts shall together constitute but one and the
same instrument.

                                       19
<Page>

          IN WITNESS WHEREOF, the parties hereto have caused this Agreement to
be duly executed, as of the day and year first above written.

                                         VASO ACTIVE PHARMACEUTICALS, INC.

                                         By:
                                             -----------------------------------
                                              Name:
                                              Title:

Attest:

     --------------------------
     Secretary

                                         KASHNER DAVIDSON SECURITIES CORP.

                                         By:
                                             -----------------------------------
                                              Name:
                                              Title:

                                       20
<Page>

                                                                       EXHIBIT A

THE WARRANTS REPRESENTED BY THIS CERTIFICATE AND THE OTHER SECURITIES ISSUABLE
UPON EXERCISE THEREOF MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO (i) AN
EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OF 1933, (ii) TO THE
EXTENT APPLICABLE, RULE 144 UNDER SUCH ACT (OR ANY SIMILAR RULE UNDER SUCH ACT
RELATING TO THE DISPOSITION OF SECURITIES), OR (iii) AN OPINION OF COUNSEL, IF
SUCH OPINION SHALL BE REASONABLY SATISFACTORY TO COUNSEL FOR THE ISSUER, THAT AN
EXEMPTION FROM REGISTRATION UNDER SUCH ACT IS AVAILABLE.

THE TRANSFER OR EXCHANGE OF THE WARRANTS REPRESENTED BY THIS CERTIFICATE IS
RESTRICTED IN ACCORDANCE WITH THE WARRANT AGREEMENT REFERRED TO HEREIN.

                            EXERCISABLE ON OR BEFORE
                   5:30 P.M., NEW YORK TIME, __________, 2008

No. W-                                                      Warrants to Purchase
                                                       130,000 shares of Class A
                                                                    Common Stock

                               WARRANT CERTIFICATE

          This Warrant Certificate certifies that Kashner Davidson Securities
Corp., or registered assigns, is the registered holder of __________ Warrants to
purchase initially, at any time from __________, 2004 until 5:30 p.m. New York
time on __________, 2008 ("Expiration Date"), up to 130,000 fully-paid and
non-assessable shares of Class A Common Stock, $0.0001 par value ("Class A
Common Stock"), of VASO ACTIVE PHARMACEUTICALS, INC., a Delaware corporation
(the "Company"), and at the initial exercise price, subject to adjustment in
certain events (the "Exercise Price"), of $6.00 per share of Class A Common
Stock upon surrender of this Warrant Certificate and payment of the Exercise
Price at an office or agency of the Company, but subject to the conditions set
forth herein and in the warrant agreement dated as of __________, 2003 between
the Company and KASHNER DAVIDSON SECURITIES CORP. (the "Warrant Agreement").
Payment of the Exercise Price shall be made by certified or official bank check
in New York Clearing House funds payable to the order of the Company or by
surrender of this Warrant Certificate.

          No Warrant may be exercised after 5:30 p.m., New York time, on the
Expiration Date, at which time all Warrants evidenced hereby, unless exercised
prior thereto, hereby shall thereafter be void.

          The Warrants evidenced by this Warrant Certificate are part of a duly
authorized issue of Warrants issued pursuant to the Warrant Agreement, which
Warrant Agreement is hereby

<Page>

incorporated by reference in and made a part of this instrument and is hereby
referred to for a description of the rights, limitation of rights, obligations,
duties and immunities thereunder of the Company and the holders (the words
"holders" or "holder" meaning the registered holders or registered holder) of
the Warrants.

          The Warrant Agreement provides that upon the occurrence of certain
events the Exercise Price and the type and/or number of the Company's securities
issuable thereupon may, subject to certain conditions, be adjusted. In such
event, the Company will, at the request of the holder, issue a new Warrant
Certificate evidencing the adjustment in the Exercise Price and the number
and/or type of securities issuable upon the exercise of the Warrants; provided,
however, that the failure of the Company to issue such new Warrant Certificates
shall not in any way change, alter, or otherwise impair, the rights of the
holder as set forth in the Warrant Agreement.

          Upon due presentment for registration of transfer of this Warrant
Certificate at an office or agency of the Company, a new Warrant Certificate or
Warrant Certificates of like tenor and evidencing in the aggregate a like number
of Warrants shall be issued to the transferee(s) in exchange for this Warrant
Certificate, subject to the limitations provided herein and in the Warrant
Agreement, without any charge except for any tax or other governmental charge
imposed in connection with such transfer.

          Upon the exercise of less than all of the Warrants evidenced by this
Certificate, the Company shall forthwith issue to the holder hereof a new
Warrant Certificate representing such number of unexercised Warrants.

          The Company may deem and treat the registered holder(s) hereof as the
absolute owner(s) of this Warrant Certificate (notwithstanding any notation of
ownership or other writing hereon made by anyone), for the purpose of any
exercise hereof, and of any distribution to the holder(s) hereof, and for all
other purposes, and the Company shall not be affected by any notice to the
contrary.

          All terms used in this Warrant Certificate which are defined in the
Warrant Agreement shall have the meanings assigned to them in the Warrant
Agreement.

                                       22
<Page>

          IN WITNESS WHEREOF, the Company has caused this Warrant Certificate to
be duly executed under its corporate seal.

Dated as of __________, 2003

                                         VASO ACTIVE PHARMACEUTICALS, INC.

                                         By:
                                             -----------------------------------
                                             Name:
                                             Title:

                                       23
<Page>

             [FORM OF ELECTION TO PURCHASE PURSUANT TO SECTION 3.1]

          The undersigned hereby irrevocably elects to exercise the right,
represented by this Warrant Certificate, to purchase:

          __________  shares of Class A Common Stock;

and herewith tenders in payment for such securities a certified or official bank
check payable in New York Clearing House Funds to the order of Vaso Active
Pharmaceuticals, Inc. in the amount of $__________, all in accordance with the
terms of Section 3.1 of the Representative's Warrant Agreement dated as of
__________, 2003 between Vaso Active Pharmaceuticals, Inc. and Kashner Davidson
Securities Corp. The undersigned requests that a certificate for such securities
be registered in the name of __________ whose address is __________ and that
such Certificate be delivered to __________ whose address is __________.

Dated: __________

                                        Signature
                                                  ------------------------------
                                        (Signature must conform in all respects
                                        to name of holder as specified on the
                                        face of the Warrant Certificate.)

                                        ----------------------------------------
                                        (Insert Social Security or Other
                                        Identifying Number of Holder)

                                       24
<Page>

             [FORM OF ELECTION TO PURCHASE PURSUANT TO SECTION 3.2]

          The undersigned hereby irrevocably elects to exercise the right,
represented by this Warrant Certificate, to purchase:

          __________  shares of Class A Common Stock;

and herewith tenders in payment for such securities __________ Warrants all in
accordance with the terms of Section 3.2 of the Representative's Warrant
Agreement dated as of __________, 2003 between Vaso Active Pharmaceuticals, Inc.
and Kashner Davidson Securities Corp. The undersigned requests that a
certificate for such securities be registered in the name of __________ whose
address is __________ and that such Certificate be delivered to __________ whose
address is __________.

Dated:  __________

                                        Signature
                                                  ------------------------------
                                        (Signature must conform in all respects
                                        to name of holder as specified on the
                                        face of the Warrant Certificate.)

                                        ----------------------------------------
                                        (Insert Social Security or Other
                                        Identifying Number of Holder)

                                       25
<Page>

                              [FORM OF ASSIGNMENT]

             (To be executed by the registered holder if such holder
                  desires to transfer the Warrant Certificate.)

  FOR VALUE RECEIVED ________________ hereby sells, assigns and transfers unto

________________________________________________________________________________
                  (Please print name and address of transferee)

this Warrant Certificate, together with all right, title and interest therein,
and does hereby irrevocably constitute and appoint __________ Attorney, to
transfer the within Warrant Certificate on the books of the within-named
Company, with full power of substitution.

Dated: __________

                                        Signature
                                                  ------------------------------
                                        (Signature must conform in all respects
                                        to name of holder as specified on the
                                        face of the Warrant Certificate.)

                                        ----------------------------------------
                                        (Insert Social Security or Other
                                        Identifying Number of Holder)

                                       26

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