Document:

EXHIBIT 4.0

 Exhibit 4.0 
  
 (FORM OF STOCK CERTIFICATE - FRONT SIDE) 
  

			
	 NUMBER
	 	SHARES
		
	 COMMON STOCK
	 	CUSIP            
	 	 	See reverse for
	 	 	certain definitions

  
 HOME FEDERAL
BANCORP, INC. OF LOUISIANA 
 INCORPORATED UNDER THE LAWS OF THE UNITED STATES 
  
 This certifies that
                     is the registered holder of
                     fully paid and non-assessable shares of the Common Stock, par value $.01 per share, of Home Federal Bancorp, Inc. of
Louisiana, Shreveport, Louisiana (the “Corporation”), incorporated under the laws of the United States. 
  
 The shares evidenced by this Certificate are transferable only on the books of the Corporation by the holder hereof, in person or by a duly authorized
attorney or legal representative, upon surrender of this Certificate properly endorsed. This Certificate and the shares represented hereby are subject to all the provisions of the Charter and Bylaws of the Corporation and any and all amendments
thereto. The shares represented by this certificate are not deposits or accounts, are not federally insured or guaranteed and are not insured by Home Federal Savings and Loan Association. This Certificate is not valid unless countersigned by
the Transfer Agent and registered by the Registrar. 
  
 IN WITNESS
WHEREOF, the Corporation has caused this Certificate to be executed by the facsimile signatures of its duly authorized officers and has caused its facsimile seal to be affixed hereto. 
  
 Dated: 
  

					
	  

	 	 (SEAL)
	 	  

	 DeNell W. Mitchell
	 	 	 	 Daniel R. Herndon

	 Corporate Secretary
	 	 	 	 President and Chief Executive Officer

 (FORM OF STOCK CERTIFICATE - BACK SIDE) 
  
 The Corporation is authorized to issue more than one class of stock,
including a class of preferred stock which may be issued in one or more series. The Corporation will furnish to any stockholder, upon written request and without charge, a full statement of the designations, preferences, limitations and relative
rights of the shares of each class authorized to be issued and, with respect to the issuance of any preferred stock to be issued in series, the relative rights, preferences and limitations between the shares of each series so far as the rights,
preferences and limitations have been fixed and determined and the authority of the Board of Directors to fix and determine the relative rights, preferences and limitations of subsequent series. 
  
 The Charter of the Corporation includes a provision which generally prohibits
any person (including an individual, company or group acting in concert) from directly or indirectly offering to acquire or acquiring the beneficial ownership of more than 10% of any class of equity securities of the Corporation. In the event that
stock is acquired in violation of this 10% limitation, the excess shares will no longer be counted in determining the total number of outstanding shares for purposes of any matter involving stockholder action and the Board of Directors of the
Corporation may cause such excess shares to be transferred to an independent trustee for sale in the open market or otherwise, with the expenses of such sale to be paid out of the proceeds of the sale. 
  
 The following abbreviations, when used in the inscription on the face of this
Certificate, shall be construed as though they were written out in full according to applicable laws or regulations: 
  

					
	 TEN COM            
	 	 -      
	 	 as tenants in common

			
	 TEN ENT            
	 	 -      
	 	 as tenants by the entireties

			
	 JT TEN            
	 	 -      
	 	 as joint tenants with right of survivorship and not

	 	 	 	 	 as tenants in common

  

											
	 UNIF GIFT MIN ACT -
	 	  

	 	 Custodian
	 	  

	 	 under
	 	 
	 	 	        (Cust)	 	 	 	(Minor)        	 	 	 	 
				
	             Uniform Gifts to Minors
Act
	 	  

	 	 	 	 
	 	 	 	 	(State)        	 	 	 	 

  
 Additional abbreviations may also be
used though not in the above list. 

 For value received,
                     hereby sell, assign and transfer unto 
  
 PLEASE INSERT SOCIAL SECURITY OR OTHER 
 TAXPAYER IDENTIFYING NUMBER OF ASSIGNEE 
  

	
	  

	 (Please print or typewrite name and address including postal zip code of assignee)

	  

	  

	  

  
              shares of Common Stock represented by this Certificate, and do hereby irrevocably constitute and appoint
             as Attomey, to transfer the said shares on the books of the within named Corporation, with full power of substitution. 
  
 Date
                    ,              
  

	
	  

	 Signature
  

	  

	 Signature

  
 NOTICE: The signature(s)
to this assignment must correspond with the name(s) as written upon the face of this Certificate in every particular, without alteration or enlargement, or any change whatever. The signature(s) should be guaranteed by an eligible guarantor
institution (bank, stockbroker, savings and loan association or credit union) with membership in an approved signature medallion program, pursuant to S.E.C. Rule 17 Ad-15.Warrant to Purchase Common Stock

 Exhibit 4.8 
  

WARRANT TO PURCHASE STOCK 
  
 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR THE SECURITIES LAWS OF ANY
STATE AND, EXCEPT AND PURSUANT TO THE PROVISIONS OF ARTICLE 5 BELOW, MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED WITHOUT AN EFFECTIVE REGISTRATION THEREOFUNLESS AND UNTIL REGISTERED UNDER SAID ACT AND APPLICABLE STATE
SECURITIES LAW OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER OF THESE SECURITIES, SUCH OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION IS EXEMPT FROM REGISTRATION. 
  

			
	 Corporation:
	  	Salmedix, Inc., a Delaware corporation
		
	 Number of Shares:
	  	18,617
		
	 Class of Stock:
	  	Common Stock
		
	 Initial Exercise Price:
	  	$1.05
		
	 Issue Date:
	  	August 24, 2004
		
	 Expiration Date:
	  	August 24, 2014 or five (5) years after the closing of the initial public offering of the common stock of Salmedix, Inc., a Delaware corporation effected pursuant to a Registration Statement on
Form S-1 (or its successor) filed under the Securities Act of 1933, as amended (being referred to herein as the “IPO”), whichever is earlier to occur.

  
 THIS WARRANT CERTIFIES
THAT, for the agreed upon value of $1.00 and for other good and valuable consideration, SILICON VALLEY BANK (“Holder”) is entitled to purchase the number of fully paid and nonassessable shares of the class of securities (the
“Shares”) of the company (the “Company”) at the Warrant Price, all as set forth above and as adjusted pursuant to Article 2 of this Warrant, subject to the provisions and upon the terms and conditions set forth in this Warrant.

  
 ARTICLE 1. EXERCISE. 
  
 1.1 Method of Exercise. Holder may exercise this Warrant by delivering
a duly executed Notice of Exercise in substantially the form attached as Appendix 1 to the principal office of the Company. Unless Holder is exercising the conversion right set forth in Article 1.2, Holder shall also deliver to the Company a check,
wire transfer (to an account designated by the Company), or other form of payment acceptable to the Company for the aggregate Warrant Price for the Shares being purchased. 
  
 1.2 Conversion Right. In lieu of exercising this Warrant as specified in Article 1.1, Holder may from time to time
convert this Warrant, in whole or in part, into a number of Shares determined by dividing (a) the aggregate fair market value of the Shares or other securities otherwise issuable upon exercise of this Warrant minus the aggregate Warrant Price of
such Shares by (b) the fair market value of one Share. The fair market value of the Shares shall be determined pursuant to Article 1.3. 

 1.3 Fair Market Value. If the Company’s common stock is traded in a public market and the
shares are common stock, the fair market value of each Share shall be the closing price of a Share reported for the business day immediately before Holder delivers its Notice of Exercise to the Company (or in the instance where the Warrant is
exercised immediately prior to the effectiveness of the Company’s initial public offering, the “price to public” per share price specified in the final prospectus relating to such offering). If the Company’s common stock is not
traded in a public market, the Board of Directors of the Company shall determine fair market value in its reasonable good faith judgment. 
  
 1.4 Delivery of Certificate and New Warrant. Promptly after Holder exercises or converts this Warrant and, if applicable, the Company receives
payment of the aggregate Warrant Price, the Company shall deliver to Holder certificates for the Shares acquired and, if this Warrant has not been fully exercised or converted and has not expired, a new Warrant representing the Shares not so
acquired. 
  
 1.5 Replacement of Warrants. On receipt of
evidence reasonably satisfactory to the Company of the loss, theft, destruction or mutilation of this Warrant and, in the case of loss, theft or destruction, on delivery of an indemnity agreement reasonably satisfactory in form and amount to the
Company or, in the case of mutilation, or on surrender and cancellation of this Warrant, the Company shall execute and deliver, in lieu of this Warrant, a new warrant of like tenor. 
  
 1.6 Treatment of Warrant Upon Acquisition of Company. 
  
 1.6.1 “Acquisition”. For the purpose of this Warrant, “Acquisition” means any sale, license, or
other disposition of all or substantially all of the assets of the Company, or any reorganization, consolidation, or merger of the Company where the holders of the Company’s securities before the transaction beneficially own less than 50% of
the outstanding voting securities of the surviving entity after the transaction. 
  
 1.6.2 Treatment of Warrant at Acquisition. 
  

A) Upon the written request of the Company, Holder agrees that, in the event of an Acquisition in which the sole consideration is cash, either (a) Holder shall
exercise its conversion or purchase right under this Warrant and such exercise will be deemed effective immediately prior to the consummation of such Acquisition or (b) if Holder elects not to exercise the Warrant, this Warrant will expire upon the
consummation of such Acquisition. The Company shall provide the Holder with written notice of its request relating to the foregoing (together with such reasonable information as the Holder may request in connection with such contemplated Acquisition
giving rise to such notice), which is to be delivered to Holder not less than ten (10) days prior to the closing of the proposed Acquisition. 
  
 B) Upon the written request of the Company, Holder agrees that, in the event of an Acquisition that is an “arms length” sale of all or substantially all of the
Company’s assets (and only its assets) to a third party that is not an Affiliate (as defined below) of the Company (a “True Asset Sale”) other than an Acquisition particularly described in subsection (A) above, either (a) Holder shall
exercise its conversion or purchase right under this Warrant and such exercise will be deemed effective immediately prior to the consummation of such Acquisition or (b) if Holder elects not to exercise the Warrant, this Warrant will continue until
the Expiration Date if the Company continues as a going concern following the closing of any such True Asset Sale. The Company shall provide the Holder with written notice of its request relating to the foregoing (together with such reasonable
information as the Holder may request in connection 

  

 2 

 
with such contemplated Acquisition giving rise to such notice), which is to be delivered to Holder not less than ten (10) days prior to the closing of the
proposed Acquisition. 
  
 C) Upon the closing of any Acquisition other than those
particularly described in subsections (A) and (B) above, either (1) the successor entity shall assume the obligations of this Warrant, and this Warrant shall be exercisable for the same securities, cash, and property as would be payable for the
Shares issuable upon exercise of the unexercised portion of this Warrant as if such Shares were outstanding on the record date for the Acquisition (if there is such a record date) and subsequent closing or (2) lawful provision shall be made,
reasonably acceptable to Holder, so that this Warrant is otherwise exercisable for such securities, cash and property during the stated term hereof. The Warrant Price and/or number of Shares shall be adjusted accordingly. 
  
 As used herein “Affiliate” shall mean any person or entity that owns or
controls directly or indirectly ten (10) percent or more of the stock of Company, any person or entity that controls or is controlled by or is under common control with such persons or entities, and each of such person’s or entity’s
officers, directors, joint venturers or partners, as applicable. 
  
 ARTICLE 2.
ADJUSTMENTS TO THE SHARES. 
  
 2.1 Stock Dividends,
Splits, Etc. If the Company declares or pays a dividend on the Shares payable in common stock, or other securities without additional consideration or payment therefor, then upon exercise of this Warrant, and, if applicable, full payment of the
applicable Warrant Price, for each Share acquired, Holder shall receive, without cost to Holder, the total number and kind of securities to which Holder would have been entitled had Holder owned the Shares of record as of the date the dividend
occurred. If the Company subdivides the Shares by reclassification or otherwise into a greater number of shares or takes any other action which increase the amount of stock into which the Shares are convertible, the number of shares purchasable
hereunder shall be proportionately increased and the Warrant Price shall be proportionately decreased. If the outstanding shares are combined or consolidated, by reclassification or otherwise, into a lesser number of shares, the Warrant Price shall
be proportionately increased and the number of Shares shall be proportionately decreased. 
  
 2.2 Reclassification, Exchange, Combinations or Substitution. Upon any reclassification, exchange, substitution, or other event that results in a change of the number and/or class of the securities issuable
upon exercise or conversion of this Warrant, without the Company’s receipt of additional consideration or payment therefor, Holder shall be entitled to receive, upon exercise or conversion of this Warrant, the number and kind of securities and
property that Holder would have received for the Shares if this Warrant had been exercised immediately before such reclassification, exchange, substitution, or other event. The Company or its successor shall promptly issue to Holder an amendment to
this Warrant setting forth the number and kind of such new securities or other property issuable upon exercise or conversion of this Warrant as a result of such reclassification, exchange, substitution or other event that results in a change of the
number and/or class of securities issuable upon exercise or conversion of this Warrant. The amendment to this Warrant shall provide for adjustments which shall be as nearly equivalent as may be practicable to the adjustments provided for in this
Article 2 including, without limitation, adjustments to the Warrant Price and to the number of securities or property issuable upon exercise of the new Warrant. The provisions of this Article 2.2 shall similarly apply to successive
reclassifications, exchanges, substitutions, or other events. 
  
 2.3 Adjustments for Diluting Issuances. The Warrant Price and the number of Shares issuable upon exercise of this Warrant shall be subject to adjustment, from time to time in the manner set forth on Exhibit A attached hereto,
provided that upon the consummation the 
  

 3 

 IPO, this section 2.3 and Exhibit A shall no longer be deemed effect or otherwise operate, and shall thereupon have no
further force or effect. 
  
 2.4 No Impairment. The Company
shall not, by amendment of its Certificate of Incorporation or through a reorganization, transfer of assets, consolidation, merger, dissolution, issue, or sale of securities or any other voluntary action, avoid or seek to avoid the observance or
performance of any of the terms to be observed or performed under this Warrant by the Company, but shall at all times in good faith assist in carrying out of all the provisions of this Article 2 and in taking all such action as may be necessary or
appropriate to protect Holder’s rights under this Article against impairment. 
  
 2.5 Fractional Shares. No fractional Shares shall be issuable upon exercise or conversion of the Warrant and the number of Shares to be issued shall be rounded down to the nearest whole Share. If a fractional
share interest arises upon any exercise or conversion of the Warrant, the Company shall eliminate such fractional share interest by paying Holder in cash the amount computed by multiplying the fractional interest by the fair market value of a full
Share. 
  
 2.6 Certificate as to Adjustments. Upon each
adjustment of the Warrant Price, the Company shall promptly notify Holder in writing, and, at the Company’s expense, promptly compute such adjustment, and furnish Holder with a certificate of its Chief Financial Officer setting forth such
adjustment and the facts upon which such adjustment is based. The Company shall, upon written request, furnish Holder a certificate setting forth the Warrant Price in effect upon the date thereof and the series of adjustments leading to such Warrant
Price. 
  
 ARTICLE 3. REPRESENTATIONS AND COVENANTS OF THE COMPANY.

  
 3.1 Representations and Warranties. The Company
represents and warrants to the Holder as follows: 
  
 (a) All
Shares which may be issued upon the exercise of the purchase right represented by this Warrant, and all securities, if any, issuable upon conversion of the Shares, shall, upon issuance, be duly authorized, validly issued, fully paid and
nonassessable, and free of any liens and encumbrances except for restrictions on transfer provided for herein or under applicable federal and state securities laws. 
  
 (b) The Company’s Capitalization table previously provided to Holder remains true and complete as of the Issue Date.

  
 3.2 Notice of Certain Events. If the Company proposes
at any time (a) to declare any dividend or distribution upon any of its stock, whether in cash, property, stock, or other securities and whether or not a regular cash dividend; (b) to offer for subscription pro rata to all of the holders of any
class or series of its stock any sale additional shares of any class or series of the Company’s stock; (c) to effect any reclassification or recapitalization of any of its stock; or (d) to merge or consolidate with or into any other
corporation, or sell, lease, license, or convey all or substantially all of its assets, or to liquidate, dissolve or wind up;, then, in connection with each such event, the Company shall give Holder: (1) at least 10 days prior written notice of the
date on which a record will be taken for such dividend, distribution, or subscription rights (and specifying the date on which the holders of common stock will be entitled thereto) or for determining rights to vote, if any, in respect of the matters
referred to in (c) and (d) above; and (2) in the case of the matters referred to in (c) and (d) above at least 10 days prior written notice of the date when the same will take place (and specifying the date on which the holders of common stock will
be entitled to exchange their common stock for securities or other property deliverable upon the occurrence of such event). 
  

 4 

 3.3 No Shareholder Rights. Except as provided in this Warrant, the Holder will not have any rights
as a shareholder of the Company until the exercise of this Warrant. 
  
 ARTICLE 4.
REPRESENTATIONS, WARRANTIES OF THE HOLDER. The Holder represents and warrants to the Company as follows: 
  
 4.1 Purchase for Own Account. This Warrant and the securities to be acquired upon exercise of this Warrant by the Holder will be acquired for
investment for the Holder’s account, not as a nominee or agent, and not with a view to the public resale or distribution within the meaning of the Act. Holder also represents that the Holder has not been formed for the specific purpose of
acquiring this Warrant or the Shares. 
  
 4.2 Disclosure of
Information. The Holder has received or has had full access to all the information it considers necessary or appropriate to make an informed investment decision with respect to the acquisition of this Warrant and its underlying securities. The
Holder further has had an opportunity to ask questions and receive answers from the Company regarding the terms and conditions of the offering of this Warrant and its underlying securities and to obtain additional information (to the extent the
Company possessed such information or could acquire it without unreasonable effort or expense) necessary to verify any information furnished to the Holder or to which the Holder has access. 
  
 4.3 Investment Experience. The Holder understands that the purchase of
this Warrant and its underlying securities involves substantial risk. The Holder has experience as an investor in securities of companies in the development stage and acknowledges that the Holder can bear the economic risk of such Holder’s
investment in this Warrant and its underlying securities and has such knowledge and experience in financial or business matters that the Holder is capable of evaluating the merits and risks of its investment in this Warrant and its underlying
securities and/or has a preexisting personal or business relationship with the Company and certain of its officers, directors or controlling persons of a nature and duration that enables the Holder to be aware of the character, business acumen and
financial circumstances of such persons. 
  
 4.4 Accredited
Investor Status. The Holder is an “accredited investor” within the meaning of Regulation D promulgated under the Act. 
  
 4.5 The Act. The Holder understands that the issuance of this Warrant and the Shares issuable upon exercise or conversion hereof have not been
registered under the Act in reliance upon a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature of the Holder’s investment intent as expressed herein. The Holder understands that this Warrant and
the Shares issued upon any exercise or conversion hereof must be held indefinitely unless subsequently registered under the Act and qualified under applicable state securities laws, or unless exemption from such registration and qualification are
otherwise available. 
  
 ARTICLE 5. MISCELLANEOUS. 
  
 5.1 Term: This Warrant is exercisable in whole or in part at any time
and from time to time on or before the Expiration Date. 
  
 5.2
Legends. This Warrant and the Shares (and the securities issuable, directly or indirectly, upon conversion of the Shares, if any) shall be imprinted with a legend in substantially the following form: 
  

 5 

 THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE ACT, OR THE SECURITIES
LAWS OF ANY STATE AND, EXCEPT AND PURSUANT TO THE PROVISIONS OF ARTICLE 5 BELOW, MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED WITHOUT AN EFFECTIVE REGISTRATION THEREOF UNDER SAID ACT AND APPLICABLE STATE SECURITIES LAW
OR, IN THE OPINION OF LEGAL COUNSEL IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER OF THESE SECURITIES, SUCH OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION IS EXEMPT FROM REGISTRATION. 
  
 5.3 Compliance with Securities Laws on Transfer. This Warrant and the
Shares issuable upon exercise of this Warrant (and the securities issuable, directly or indirectly, upon conversion of the Shares, if any) may not be transferred or assigned in whole or in part without compliance with applicable federal and state
securities laws by the transferor and the transferee (including, without limitation, the delivery of investment representation letters and legal opinions reasonably satisfactory to the Company, as reasonably requested by the Company). The Company
shall not require Holder to provide an opinion of counsel if the transfer is to Silicon Valley Bancshares (Holder’s parent company) or any other affiliate of Holder. Additionally, the Company shall also not require an opinion of counsel if
there is no material question as to the availability of current information as referenced in Rule 144(c), Holder represents that it has complied with Rule 144(d) and (e) in reasonable detail, the selling broker represents that it has complied with
Rule 144(f), and the Company is provided with a copy of Holder’s notice of proposed sale. 
  
 5.4 Transfer Procedure. Upon receipt by Holder of the executed Warrant, Holder will transfer all of this Warrant to Silicon Valley Bancshares, Holder’s parent company, by execution of an Assignment
substantially in the form of Appendix 2. Subject to the provisions of Article 5.3 and upon providing Company with written notice, Silicon Valley Bancshares and any subsequent Holder may transfer all (but not a part) of this Warrant or the Shares
issuable upon exercise of this Warrant (or the Shares issuable directly or indirectly, upon conversion of the Shares, if any) to any transferee, provided, however, in connection with any such transfer, Silicon Valley Bancshares or any subsequent
Holder will give the Company notice of the transfer of the Warrant being transferred with the name, address and taxpayer identification number of the transferee and Holder will surrender this Warrant to the Company for reissuance to the
transferee(s) (and Holder if applicable) and the transferee shall agree in writing to be bound by all the terms and conditions of this Warrant as if it were the Holder hereunder. The Company may refuse to transfer this Warrant or the Shares to any
person who directly competes with the Company, unless, in either case, the common stock of the Company has been registered with the SEC under the Securities Exchange Act of 1934, as amended is publicly traded. 
  
 5.5 Notices. All notices and other communications from the Company to
the Holder, or vice versa, shall be deemed delivered and effective when given personally or mailed by first-class registered or certified mail, postage prepaid (or on the first business day after transmission by facsimile), at such address as may
have been furnished to the Company or the Holder, as the case may be, in writing by the Company or such Holder from time to time. Effective upon receipt of the fully executed Warrant and the initial transfer described in Article 5.4 above, all
notices to the Holder shall be addressed as follows until the Company receives notice of a change of address in connection with a transfer or otherwise: 
  

 6 

 Silicon Valley Bancshares 
 Attn: Treasury Department 
 3003 Tasman Drive, HA 200 
 Santa Clara, CA 95054 
 Telephone: 408-654-7400 
 Facsimile: 408-496-2405 
  
 Notice
to the Company shall be addressed as follows until the Holder receives notice of a change in address: 
  
 Salmedix, Inc. 
 Attn: Chief Financial Officer 
 9380 Judicial Drive, San Diego, CA 92121 
 Telephone: 858-622-5050 
 Facsimile: 858-622-5060 
  
 5.6
Waiver. This Warrant and any term hereof may be changed, waived, discharged or terminated only by an instrument in writing signed by the party against which enforcement of such change, waiver, discharge or termination is sought. 

 
 5.7 Attorney’s Fees. In the event of any dispute between the
parties concerning the terms and provisions of this Warrant, the party prevailing in such dispute shall be entitled to collect from the other party all costs incurred in such dispute, including reasonable attorney’s fees. 
  
 5.8 Automatic Conversion upon Expiration. In the event that, upon the
Expiration Date, the fair market value of one Share (or other security issuable upon the exercise hereof) as determined in accordance with Section 1.3 above is greater than the Exercise Price in effect on such date, then this Warrant shall
automatically be deemed on and as of such date to be converted pursuant to Section 1.2 above as to all Shares (or such other securities) for which it shall not previously have been exercised or converted, and the Company shall promptly deliver a
certificate representing the Shares (or such other securities) issued upon such conversion to the Holder. 
  
 5.9 Counterparts. This Warrant may be executed in counterparts, all of which together shall constitute one and the same agreement. 
  
 5.10 Governing Law. This Warrant shall be governed by and construed in
accordance with the laws of the State of California, without giving effect to its principles regarding conflicts of law. 
  
 5.11 Market Stand-Off. Holder, by acceptance of this Warrant and any of the Shares or other securities issuable upon exercise or conversion of this
Warrant, hereby agrees that it shall not offer, sell, transfer or otherwise dispose or agree to dispose of this Warrant, the Shares or any other securities of the Company, during any period of time requested by the Company in connection with the
initial public offering of the Company’s securities only to the extent, however, and under the same circumstances and subject to the same restrictions as apply to all officers and directors of the Company and holders of at least 1% of the
Company’s outstanding securities. Holder shall execute such documents as may be requested to further evidence this agreement. 
  

 7 

									
	 “COMPANY”
	 	 	 	 
			
	SALMEDIX, INC.	 	 	 	SALMEDIX, INC.
					
	By:	 	 /s/    DAVID S. KABAKOFF
	 	 	 	By:	 	 /s/    ANITA I. BUSQUETS

					
	Name:	 	 David S. Kabakoff
	 	 	 	Name:	 	 Anita I. Busquets

	 	 	 (Print)
	 	 	 	 	 	 (Print)

	Title:	 	 Chairman of the Board, President or Vice President or CEO
	 	 	 	 Title:
	 	 Chief Financial and Administrative Officer, and Corporate Secretary, Assistant Treasurer or Assistant Secretary

			
	 “HOLDER”
	 	 	 	 
			
	SILICON VALLEY BANK	 	 	 	 
					
	By:	 	 /s/    ROBERT C. LAKE
	 	 	 	 	 	 
					
	Name:	 	 Robert C. Lake
	 	 	 	 	 	 
	 	 	 (Print)
	 	 	 	 	 	 
	Title:	 	 Vice President
	 	 	 	 	 	 

  

 8 

 APPENDIX 1 
  
 NOTICE OF EXERCISE 
  
 1. Holder elects to purchase                  shares of the Common
Stock of Salmedix, Inc. pursuant to the terms of the attached Warrant, and tenders payment of the purchase price of the shares in full. 
  
 [or] 
  
 1. Holder elects to convert the attached Warrant into Shares/cash [strike one] in the manner specified in the Warrant. This conversion is exercised for
                             of the Shares covered by the Warrant. 
  
 [Strike and initial paragraph that does not apply.] 
  
 2. Please issue a certificate or certificates representing the shares in the
name specified below: 
  

	 	

 Holders Name 
  

	 	

  

	 	

 (Address) 
  
 3. By its execution below and for the benefit of the Company, Holder hereby
restates each of the representations and warranties in Article 4 of the Warrant as the date hereof. In addition, Holder acknowledges and agrees that it is accepting the Shares subject to all of the terms and conditions set forth in the Warrant,
including, without limitation, the market-stand-off provisions. 
  

			
	HOLDER:
	
	 
		
	By:	 	 
	Name:	 	 
	Title:	 	 
		
	(Date):	 	 

 APPENDIX 2 
  
 ASSIGNMENT 
  
 For value received, Silicon Valley Bank hereby sells, assigns and transfers unto 
  

			
	 Name:
	  	Silicon Valley Bancshares
	 Address:
	  	3003 Tasman Drive (HA-200)
	 	  	Santa Clara, CA 95054
		
	 Tax ID:
	  	91-1962278

  
 that
certain Warrant to Purchase Stock issued by Salmedix, Inc. (the “Company”), on August     , 2004 (the “Warrant”) together with all rights, title and interest therein. 
  

			
	 SILICON VALLEY BANK

		
	By:	 	 
	Name:	 	 
	Title:	 	 

  
 Date: August
    , 2004 
 By its execution below, and for the benefit of the Company, Silicon Valley Bancshares makes each of the representations and
warranties set forth in Article 4 of the Warrant as of the date hereof. 
  

			
	 SILICON VALLEY BANCSHARES

		
	By:	 	 
	Name:	 	 
	Title:	 	 

 EXHIBIT A 
  

(a) If, after the date hereof, the Company shall issue or sell: 
  
 (i) Additional Shares (defined below) without consideration or for a consideration per share less than the higher of (A) the Warrant Price and (B)
the fair market value of a share of Common Stock in effect immediately prior to such issue or sale, 
  
 then, and in each such case, the Warrant Price shall be reduced, concurrently with such issue or sale, to a price (calculated to the nearest .001 of a cent) determined by multiplying such Warrant Price by a fraction:

  
 (i) the numerator of which shall be (A) the number of
shares of Common Stock outstanding immediately prior to such issue or sale (including any shares of Common Stock issuable upon conversion of outstanding shares of Preferred Stock of the Company and issuance upon exercise of outstanding options,
warrants or other convertible securities) plus (B) the number of shares of Common Stock that the aggregate consideration received by the Company upon such issuance or sale (or, in the case of Common Stock equivalents exercisable for Additional
Shares, receivable by the Company upon exercise or exchange) would purchase at such Warrant Price, and 
  
 (ii) the denominator of which shall be the number of shares of Common Stock outstanding immediately after such issue or sale (assuming, in the case
of Common Stock equivalents exercisable for Additional Shares, exercise or exchange of all such Common Stock equivalents and including any shares of Common Stock issuable upon conversion of outstanding shares of Preferred Stock and issuable upon
exercise of outstanding options, warrants or other convertible securities). 
  
 (b) For the purposes hereof, the consideration for the issue or sale of Additional Shares shall, irrespective of the accounting treatment of such consideration, (i) insofar as it consists of cash, be computed at the net amount of
cash received by the Company, and (ii) insofar as it consists of property (including securities) other than cash, be computed at the fair value thereof at the time of such issue or sale as determined in good faith by the Company’s Board of
Directors. In the event of a dispute in good faith by the Holder as to the fair market value of the consideration consisting of property, at the option of the Investor, the Company shall engage a consulting firm or investment banking firm mutually
agreed to by the Holder and the Company to prepare an independent appraisal of the fair market value of such property to be distributed. The expenses of such appraisal shall be borne one-half (1/2) by the Company and one-half (1/2) by the Holder.

  
 (c) Notwithstanding anything contained herein to the contrary, the
consideration for any Common Stock equivalents shall be the total amount of consideration received by the Company for the issuance thereof plus the minimum amount of consideration payable to the Company upon exercise, conversion or exchange of the
Common Stock equivalents (the “Net Consideration”) determined as of the date of issuance of such Common Stock Equivalents. Any obligation, agreement or understanding to issue Common Stock equivalents at any time in the future shall
be deemed to be an issuance at the time such obligation or agreement is made or arises. No adjustment of the Warrant Price shall be made hereunder upon the issuance of any shares of Common Stock which are issued pursuant to the exercise, conversion
or exchange of any Common Stock Equivalents if any adjustment shall previously have been made upon the issuance of any such Common Stock Equivalents. 
  
 Should the Net Consideration for any such Common Stock Equivalents be increased or decreased from time to time, then, upon the effectiveness of such
change, the Warrant Price will 

 
be that which would have been obtained (i) had the adjustments made upon the issuance of such Common Stock Equivalents been made upon the basis of the actual
Net Consideration (as so increased or decreased) of such Common Stock Equivalents, and (ii) had adjustments to such Warrant Price since the date of issuance of such Common Stock Equivalents been made to such Warrant Price as adjusted pursuant to (i)
above. Any adjustment of the Warrant Price with respect to this paragraph which relates to Common Stock Equivalents shall be disregarded if, as, and when all of such Common Stock Equivalents expire or are canceled without being exercised, so that
the Warrant Price effective immediately upon cancellation or expiration shall be equal to the Warrant Price in effect at the time of the issuance of the expired or canceled Common Stock Equivalents, with such additional adjustments as would have
been made to such Warrant Price had the expired or canceled Common Stock Equivalents not been issued. 
  
 (d) “Additional Shares” means all shares of Common Stock, whether or not subsequently reacquired or retired by the Company other than (i) Common Stock issued pursuant to a transaction described in
this Warrant; (ii) shares of Common Stock issuable or issued to employees, consultants, directors or officers of the Company pursuant to a stock option plan or stock purchase plans or agreements on terms approved by the Board of Directors of the
Company; (iii) shares of Common Stock issued or issuable in connections with a bona fide acquisition of another business entity by the Company, whether by merger, consolidation, sale of assets or sale or exchange of stock, whereby the Company will
own more than fifty percent (50%) of the voting stock of such business entity or business segment in a transaction approved the Board of Directors of the Company; (iv) shares of Common Stock issued or issuable upon conversion of the Company’s
Preferred Stock; (v) shares of Common Stock issued or issuable (a) in a public offering before which, or in connection with which, all outstanding shares of the Company’s Preferred Stock will be converted to Common Stock or (b) upon exercise of
warrants or other rights granted to underwriters in connection with such a public offering; or (vi) any right, option or warrant to subscribe for, purchase or otherwise acquire any security convertible into any security excluded from the definition
of “Additional Stock” pursuant to subsections (i) through (v) above. 
  
 (e) The number of shares of Common Stock that the holder of this Warrant shall be entitled to receive upon each exercise hereof after any adjustment pursuant hereto shall be determined by multiplying (i) the number of shares of
Common Stock that were issuable immediately prior to such adjustment, by (ii) the fraction of which (A) the numerator is the Warrant Price immediately prior to such adjustment and (B) the denominator is the Warrant Price immediately following such
adjustment. 
  

 2

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