Document:

exv10w24

Exhibit 10.24

LEASE AGREEMENT

NORTH CAROLINA

COUNTY OF WAKE

     THIS LEASE AGREEMENT dated the 11th day of August, 2004 and entered into between
REGENCY PARK CORPORATION, a North Carolina corporation having its principal place of business in
Cary, North Carolina (the “Landlord”), and Cornerstone BioPharma, a Nevada corporation having its
principal place of business in Cary, North Carolina (the “Tenant”).

W I T N E S S E T H:

     DEFINITIONS:

     The following definitions shall be deemed to control herein.

     ADDITIONAL RENT: Any adjustments to Annual Rental and other sums due Landlord from Tenant.

     BASE OPERATING EXPENSES: Means Operating Expenses for the Operating Year ending November 30,
2004, which amount shall be as certified by Landlord’s auditors.

     BASE REAL ESTATE TAXES: Means the lesser of:

     a. the real estate taxes levied or imposed for the tax year ending December 31, 2004, which
amount shall be as certified by Landlord’s auditors; or

     b. such lesser amount as may be fixed, settled, and compromised, consented to, or determined
as a result of contestation or otherwise.

     BUILDING: 2000 Regency Parkway located in Cary, North Carolina.

     LEASE: This Lease Agreement with all Exhibits and Riders attached thereto.

     LEASE YEAR: As used herein (i) shall mean each and every 12-month period during the term of
this Lease, or (ii) (in the event of Lease expiration or termination) shall mean the period between
the last 12-month period and said expiration or termination. The first such 12-month period shall
commence on the 1st day of November, 2004, and end on the 31st day of
October, 2005.

     OPERATING EXPENSES: The Landlord’s cost of operating the Building and Property as more
particularly described in Exhibit E attached hereto and made a part hereof by this
reference.

     OPERATING YEAR: Means a year commencing on December 1, and terminating on November 30,
provided that Landlord shall be permitted at anytime and from time to time to change the
commencement and termination dates of any operating year of the Landlord.

 

 

     PREMISES: The space as outlined on the floor plan which is attached hereto as Exhibit
A and made a part hereof by this reference. The Premises constitutes Five Thousand Five Hundred
Forty-Three (5,543) rentable square feet located on the 2nd floor of the Building and is
designated as Suite 255.

     PROPERTY: The land upon which the Building is located, which land is more particularly
described in Exhibit B attached hereto and made a part hereof by this reference.

     RENTABLE AREA: Five Thousand Five Hundred Forty-Three (5,543) square feet located within the
Building.

     REAL ESTATE TAXES: Includes (i) personal property taxes (attributable to the year in which
assessed) imposed upon the furniture, fixtures, machinery, equipment, apparatus, systems, and
appurtenances used in connection with the Building and the Property for the operating thereof; and
(ii) real estate taxes, assessments, sewer rents, rates and charges, taxes based upon the receipt
of rent and any other federal, state, or local governmental charge, general, special, ordinary, or
extraordinary (but not including income or franchise taxes or any other taxes imposed upon or
measured by Landlord’s income or profits, unless the same shall be imposed in lieu of real estate
taxes) or any other tax which may now or hereafter be levied or assessed against the Property, the
Building, any other improvements hereinafter constructed on the Property, or the rents derived from
the Property, the Building and such other improvements. (In the case of special taxes or
assessments which may be payable in installment, only the amount of each installment paid during a
calendar year shall be included in the taxes for that year.)

     REAL ESTATE TAX YEAR: Means each successive 12-month period following and corresponding to the
period in respect of which the base real estate taxes are established irrespective of the period or
periods which may from time to time in the future be established by competent authority for the
purposes of levying or imposing real estate taxes.

PREMISES

     Landlord, for and in consideration of the rents, covenants, agreements, and stipulations
herein contained, to be paid, kept and performed by the Tenant, has leased and by these presents
leases unto the Tenant, and Tenant hereby agrees to lease upon the terms and conditions herein
contained, the Premises located in the Building situate upon the Property.

FINISHING OF PREMISES

     The Premises shall be finished by the Landlord at its expense in accordance with the
provisions of Exhibit C which is attached to and forms a part of this Lease.

     All other improvements to the Premises shall be made at the Tenant’s expense and must be
performed in accordance with accurate working drawings and specifications that are to be submitted
to and approved by the Landlord in writing prior to the commencement of such work.

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1.0 TERM

     The term of this Lease shall be for a period of five (5) years commencing on the
1st day of November, 2004, (hereinafter referred to as the “Commencement Date”), and
ending on the 31st day of October, 2009, inclusive. If, however, for any reason Landlord
is unable to deliver possession of the Premises to Tenant upon the Commencement Date, Landlord
shall not be liable for any damage caused thereby, nor shall this Lease become void or voidable
but, rather, the term specified herein shall commence upon the date of delivery of possession of
the Premises to Tenant and shall terminate five (5) years subsequent to the Commencement Date.
Tenant shall not be liable for any rent hereunder until such time as Landlord shall have delivered
possession of the Premises to Tenant and substantially completed the work described in Exhibit
C unless the delay is caused by Tenant. If, however, Landlord is unable to deliver possession
of the Premises to Tenant within six (6) months after the Commencement Date for any reason other
than the fault or neglect of Tenant, then this Lease may be terminated by either party without
liability to the other upon fifteen (15) days prior written notice to the other party. Should the
lease term commence upon any date other than the Commencement Date hereinabove specified, Landlord
and Tenant shall execute and acknowledge a written statement setting forth the actual date of
commencement of the lease term, which statement may be recorded by either party and a copy of which
shall be attached as Exhibit D to this Lease.

2.0 ANNUAL RENTAL AND ADJUSTMENTS THEREOF

     2.01 ANNUAL RENTAL: Tenant agrees to pay Landlord, at Landlord’s address above, or at such
other place as Landlord may designate in writing, without demand, deduction, credit or setoff and
in lawful money of the United States of America:

     Rental of One Hundred Two Thousand Five Hundred Forty-Five and 52/100 Dollars ($102,545.52)
per year (“Annual Rent”), payable in equal monthly installments of Eight Thousand Five Hundred
Forty-Five and 46/100 Dollars ($8,545.46), in advance, on or before the first day of each calendar
month for the period November 1, 2004, up to and including January 31, 2005.

     Rental of One Hundred Five Thousand Three Hundred Seventeen and 04/100 Dollars ($105,317.04)
per year (“Annual Rent”), payable in equal monthly installments of Eight Thousand Seven Hundred
Seventy-Six and 42/100 Dollars ($8,776.42), in advance, on or before the first day of each calendar
month for the period February 1, 2005, up to and including January 31, 2006.

     Rental of One Hundred Eight Thousand Eighty-Eight and 56/100 Dollars ($108,088.56) per year
(“Annual Rent”), payable in equal monthly installments of Nine Thousand Seven and 38/100 Dollars
($9,007.38), in advance, on or before the first day of each calendar month for the period February
1,2006, up to and including January 31, 2007.

     Rental of One Hundred Ten Thousand Eight Hundred Fifty-Nine and 96/100 Dollars ($110,859.96)
per year (“Annual Rent”), payable in equal monthly installments of Nine Thousand Two Hundred
Thirty-Eight and 33/100 Dollars ($9,238.33), in advance, on or before

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the first day of each calendar month for the period February 1, 2007, up to and including
January 31, 2008.

     Rental of One Hundred Thirteen Thousand Six Hundred Thirty-One and 48/100 Dollars
($113,631.48) per year (“Annual Rent”), payable in equal monthly installments of Nine Thousand Four
Hundred Sixty-Nine and 29/100 Dollars ($9,469.29), in advance, on or before the first day of each
calendar month for the period February 1, 2008, up to and including October 31, 2009.

     The Tenant is also obligated to pay to the Landlord Additional Rent and certain other sums as
provided for herein.

     2.02 ADDITIONAL RENT: Any adjustment to Annual Rent and other sums due Landlord from Tenant
shall be referred to collectively as “Additional Rent.”

     2.02.01 OPERATING EXPENSES: Prior to commencement of each Operating Year or as soon thereafter
as is reasonably possible, Landlord will furnish to Tenant an estimate of the Operating Expenses
for such Operating Year and if the same shall be in excess of the Base Operating Expenses, the
installments of rent payable hereunder in respect of each month of such Operating Year shall be
increased byway of Additional Rent by an amount equal to one-twelfth (1/12) of three and forty-nine
one hundredths percent (3.49%) of such excess and Tenant shall make payment thereof to Landlord
accordingly (“Tenant’s Estimated Share”).

     After the end of each Operating Year, the Landlord shall furnish to Tenant a statement of
Landlord’s actual Operating Expenses for such Operating Year and Tenant shall pay to Landlord an
amount equal to of three and forty-nine one hundredths percent (3.49%) of the excess of such
Operating Expenses over the Base Operating Expenses (“Tenant’s Actual Share”). If Tenant’s Actual
Share is greater than the amount paid by Tenant to Landlord as Tenant’s Estimated Share, then
Tenant shall pay this difference to Landlord within fourteen (14) days after delivery of such
statement. If Tenant’s Actual Share is less than the amount paid by Tenant to Landlord as Tenant’s
Estimated Share, then Landlord shall refund the excess to Tenant within fourteen (14) days after
delivery of such statement.

     Nothing contained in this Article shall be construed at any time so as to reduce the monthly
installments of rent payable hereunder below the amount stipulated in Article 2.01.

     If this Lease shall terminate other than on the expiry of an Operating Year in any Operating
Year, then in computing the amount payable by Tenant under this Article for the period from the
commencement of the Operating Year in which the Lease terminates until the date of termination, the
Base Operating Expenses shall be deducted from the Operating Expenses for such Operating Year and
Tenant shall pay one-three hundred sixty-fifth (1/365) of three and forty-nine one hundredths
percent (3.49%) for each day of such Operating Year during which this Lease shall have been in full
force and effect.

     The obligations of the parties hereto to adjust sums owed pursuant to this Article shall
survive the expiration of the term of this Lease

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     Failure of Landlord to furnish a statement of actual Operating Expenses or to give notice of
an adjustment to Annual Rent under this Article in a timely manner shall not prejudice or act as a
waiver of Landlord’s right to furnish such statement or give such notice at a subsequent time or to
collect any adjustments to the Base Rent for any preceding period.

     2.02.02 REAL ESTATE TAXES: If at any time or from time to time during the term of this Lease,
the Real Estate Taxes for or attributable to any Real Estate Tax Year shall be in excess of the
Base Real Estate Taxes, and/or if any new tax or increase of the effective rate of present taxes
shall become effective after the date hereof but before the normal tax escalation provision shall
take effect, the rent payable hereunder in respect of such year shall be increased by an amount
equal to of three and forty-nine one hundredths percent (3.49%) of such excess and/or such new tax
or increase (the “Tenant’s Tax Share”). Tenant shall pay to Landlord, not later than the sixty (60)
days prior to the tax due date, or such other date as may be specified in writing to Tenant by
Landlord, the Tenant’s Tax Share for such year. Where at any time such amount has become payable to
Landlord hereunder, in addition to such amount, subsequent monthly installments of rent shall be
increased by an amount equal to one-twelfth (1/12) of the Tenant’s Tax Share, and such monthly
amounts when paid to Landlord shall be available (without interest) as a credit against subsequent
obligations of Tenant to Landlord under this Article. Landlord shall furnish to Tenant upon the
specific written request of Tenant copies of all notices of valuation and assessment and all tax
bills received by Landlord.

     Tenant shall pay to Landlord as Additional Rent of three and forty-nine one hundredths percent
(3.49%) of any expenses incurred by Landlord in obtaining or attempting to obtain a reduction of
any Real Estate Taxes. Real Estate Taxes which are being contested by Landlord shall nevertheless
be included for purposes of the computation of the liability of Tenant under this Article;
provided, however, that in the event that Tenant shall have paid any amount of increased rent
pursuant to this Article and Landlord shall thereafter receive a refund of any portion of the Real
Estate Taxes on which such payment shall have been based, Landlord shall pay to Tenant the
appropriate portion of such refund after deduction of the aforementioned expenses.

     Landlord shall have no obligation to contest, object to or to litigate the levying or
imposition of any Real Estate Taxes and may settle, compromise, consent to, waive or otherwise
determine in its discretion any Real Estate Taxes without notice to, consent or approval of Tenant.

     Nothing contained in this Article shall be construed at any time so as to reduce the monthly
installments of rent payable hereunder below the amount stipulated in Article 2.01.

     If the termination date of the Lease shall not coincide with the end of a Real Estate Tax
Year, then in computing the amount payable under this Article for the period between the
commencement of the applicable Real Estate Tax Year in question and the termination date of this
Lease, the Base Real Estate Taxes shall be deducted from the Real Estate Taxes for the applicable
Real Estate Tax Year and, if such Real Estate Taxes exceed the Base Real Estate Taxes, the Tenant
shall pay one-three hundred sixty-fifth (1/365) of three and forty-nine one hundredths percent
(3.49%) for each day of such Real Estate Tax Year during which the Lease shall have been in full
force and effect.

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     Tenant’s obligation to pay under this Article for the final period of the Lease shall survive
the expiration of the term of this Lease.

     Failure of Landlord to furnish a statement of actual Tax Expenses or to give notice of an
adjustment to Annual Rent under this Article in a timely manner shall not prejudice or act as a
waiver of Landlord’s right to furnish such statement or give such notice as a subsequent time or to
collect any adjustments to the Annual Rent for any preceding period.

     2.02.03 INTEREST FOR LATE PAYMENT: Any payment provided for herein to be made by the Tenant
and not received by Landlord on the due date specified in this Lease shall accrue interest from the
due date at the rate of two percent (2%) above the published prime rate of First Union National
Bank of North Carolina in effect from time to time (the “Prime Rate”).

     For purposes of computing interest hereunder, changes in the Prime Rate shall be effective on
the date of each change.

     2.03 SECURITY DEPOSIT: Tenant shall pay to the Landlord upon, upon execution of the Lease
Eight Thousand Five Hundred Forty-Five and 46/100 Dollars ($8,545.46), equal to one (1) monthly
installment of Annual Rent (herein called “Security Deposit”), which amount shall be security for
the full and faithful performance and observance by Tenant of the covenants, terms and conditions
of this Lease, including, without limitation, the payment of Annual Rent and Additional Rent, on
the part of Tenant to be kept and performed. No interest shall be payable on the Security Deposit.
Tenant acknowledges that the Security Deposit is not an advance payment of rent or a measure of
Landlord’s damages in the case of default by Tenant. Upon the occurrence of an Event of Default
under the Lease, Landlord may use, apply or retain the whole or any part of the Security Deposit so
deposited to the extent required for the payment of any Annual Rent and Additional Rent or any
other sum as to which Tenant is in default or for the payment of any other damage, injury, expense
or liability resulting from any Event of Default. Following any such application of the Security
Deposit, Tenant shall pay to Landlord on demand the amount necessary to restore the Security
Deposit to its original amount. In the event that Tenant shall fully and faithfully comply with all
of the terms, provisions, covenants and conditions of this Lease, the Security Deposit shall be
returned to Tenant within thirty (30) days after the termination of this Lease subject to the
retention of an amount estimated by Landlord to be sufficient to satisfy Tenant’s Additional Rent
obligations hereunder. In the event of a sale of the Building or a lease of the Building, subject
to this Lease, Landlord shall be released from all liability for the return of the Security Deposit
and Tenant shall look to the new landlord for the return of the Security Deposit. This provision
shall apply to every transfer or assignment made of the Security Deposit to a new landlord. The
Security Deposit shall not be assigned or encumbered by Tenant without the written consent of
Landlord, and such assignment or encumbrance without Landlord’s consent shall be void.

3.0 USE

     The Premises shall be used and occupied only for general office use and shall not be used or
occupied for any other purpose without the prior written consent of Landlord. Tenant shall not
display any signs on the Property without prior written consent of Landlord. Tenant shall not

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conduct, or allow to be conducted, on the Premises any business, or permit any act, (i) which
constitutes a nuisance, (ii) which is contrary to or in violation of the laws, statutes, or
ordinances of the United States, or the State or City in which the Premises are located, or (iii)
which is dangerous to persons or property or which may invalidate (or increase the premium for) any
policy of insurance carried on the Building or the Premises. Tenant will comply with all police,
fire, sanitary and all other laws and regulations imposed by any governmental or municipal
authority or body or by Landlord’s fire insurance underwriters. Any violation of this provision by
the Tenant shall be an Event of Default entitling Landlord to exercise any rights or remedies
contained herein or provided by law.

4.0 SERVICES OF LANDLORD

     The Landlord shall provide, at the Landlord’s expense except as otherwise provided, the
following services:

     a. Janitorial service in and about the Premises, Saturdays, Sundays and holidays excepted.

     b. Heat and air-conditioning, daily from 8:00 a.m. to 6:00 p.m., and 8:00 a.m. to 1:00 p.m. on
Saturdays (if not a holiday), Sundays and holidays excepted, sufficient to maintain comfortable
temperature on the basis of one person per 100 square feet of space reasonably subdivided. This
paragraph shall conform to any government regulations preserving limitations thereon and such
conformity shall be deemed to satisfy this Landlord obligation.

     Whenever heat generating machines or equipment which affect the temperature otherwise
maintained by the air-conditioning system are used in the Premises, Landlord reserves the right, at
its option, either to require Tenant to discontinue the use of such heat generating machines or
equipment or to install supplementary air-conditioning equipment in the Premises. The cost of such
installation shall be paid by Tenant to Landlord promptly on being billed therefor, and the cost of
operation and maintenance of said supplementary equipment shall be paid by Tenant to Landlord
promptly on the monthly rent payment dates at such rates as may be agreed on, but in no event at a
rate less than Landlord’s actual cost therefor of labor, materials and utilities.

     c. Water for drinking, lavatory and toilet purposes.

     d. Passenger elevator service at all times. Any or all elevator service may be automatic.

     e. Window washing of all exterior windows, both inside and out, weather permitting.

     f. Provision, installation and replacement of ballasts and tubes for lighting purposes.

     g. Removal of ice and snow from walks, drives and parking facilities.

     h. Electricity typically provided in general office space, specifically excluding any
extraordinary requirements of the Tenant.

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     If Tenant shall require electric current in excess of that usually furnished or supplied for
use of the Premises as general office space, Tenant shall first procure the consent of Landlord,
(which Landlord may refuse in its sole discretion), to the use thereof. Landlord may cause an
electric check meter to be installed in the Premises. Landlord shall also have the right to cause a
reputable independent electrical engineering or consulting firm to survey and determine the value
of the electric service furnished for such excess electric current. The cost of any such survey or
meters and of installation, maintenance and repair thereof shall be paid for by Tenant. Tenant
agrees to pay to Landlord, promptly upon demand therefor, for all such electric current consumed as
shown by said meters or by said survey at the rates charged for such services by the city, or the
local public utility, as the case may be, furnishing the same, plus any additional expense incurred
in monitoring the electric current so consumed.

     Tenant covenants and agrees that at all times its use of electric current shall never exceed
Tenant’s proportionate share of the capacity of existing feeders to the Building or the risers of
wiring installation. Any riser or risers or wiring to meet Tenant’s excess electrical requirements,
upon written request of Tenant, will be installed by Landlord, at the sole cost and expense of
Tenant if, in Landlord’s sole judgment, the same are necessary and will not cause permanent damage
or injury to Building or Premises or cause or create a dangerous or hazardous condition or entail
excessive or unreasonable alteration, repairs or expense or interfere with or disturb other tenants
or occupants.

     Should Tenant require any additional work or service, including but not limited to the
additional work or service described above, including service furnished outside the stipulated
hours, Landlord may, on terms to be agreed, upon reasonable advance notice by Tenant, furnish such
additional service. Tenant agrees to pay the Landlord such charges as may be agreed on, but in no
event at a charge less than Landlord’s actual cost plus overhead for the additional services
provided, it being agreed that the cost to the Landlord of such additional services shall be
excluded from Operating Expenses.

     Landlord does not warrant that any of the services referred to above, or any other services
which Landlord may supply, will be free from interruption. Tenant acknowledges that any one or more
of such services may be suspended by reason of accident or of repairs, alterations or improvements
necessary to be made, or by strikes or lockouts, or by reason of operation of law, or causes beyond
the reasonable control of Landlord. Any such interruption or discontinuance of service shall not
constitute an eviction or disturbance of Tenant’s use and possession of the Premises, or any part
thereof, or render Landlord liable to Tenant for damages by abatement of rent or otherwise, or
relieve Tenant from performance of Tenant’s obligations under this Lease.

5.0 TENANT’S ACCEPTANCE AND MAINTENANCE OF PREMISES

     Tenant, on occupancy of the Premises, represents to the Landlord that it has examined and
inspected the same, finds them to be as represented by the Landlord and satisfactory for Tenant’s
intended use, and such occupancy evidences Tenant’s acceptance “AS IS.” Landlord makes no
representation or warranty as to the condition of said Premises. Tenant shall maintain (and so
deliver at the end of the Lease) each and every part of the Premises in good repair and condition,
and shall make, at Tenant’s sole cost and expense, such replacements, restorations, renewals or
repairs, in quality equivalent or better than the original work, as may be required to

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so maintain the same, ordinary wear and tear only excepted. Tenant, however, shall make no
structural or interior alterations, additions or improvements to the Premises without Landlord’s
prior written consent, and any work performed by Tenant shall be done in good and workmanlike
manner, and so as not to disturb or inconvenience other tenants in the Building. Tenant shall not
at any time permit any work to be performed on the Premises except by duly licensed contractors or
artisans, each of whom must carry general public liability insurance in form and content
satisfactory to the Landlord, certificates of which shall be furnished Landlord. At no time may
Tenant do any work that results in a claim of lien against Landlord. All alterations, additions or
improvements (including, but not limited to, floor covering, wall covering, wall and ceiling
lighting fixtures, carpet, drapes and drapery hardware) made or installed by Tenant or by Landlord
for Tenant’s benefit to the Premises, shall become the property of Landlord upon the termination or
earlier expiration of this Lease. Landlord reserves the right to require Tenant, at Tenant’s
expense, (i) to remove any improvements or additions made to the Premises by Tenant, or by Landlord
for Tenant’s benefit, upon the expiration or earlier termination of this Lease; and (ii) to repair
all injury done by or in connection with installation or removal of said improvements or additions.
Tenant further agrees to do so prior to the expiration date of this Lease, or within thirty (30)
days after notice from Landlord, whichever shall be later, provided that Landlord gives such notice
no later than thirty (30) days prior to the expiration date of this Lease.

     If the sprinkler system as installed in the Building or any of its appliances shall be damaged
or injured or not in proper working order by reason of any act or omission of the Tenant, Tenant’s
agents, servants, employees, licensees or visitors, the Tenant shall forthwith restore the same to
good working conditions at its own expense. If the Board of Fire Underwriters of Fire Insurance
Exchange or any bureau, department or official of the state, county or city government, require or
recommend that any changes, modifications, alterations or additional sprinkler heads or other
equipment be made or supplied by reason of the Tenant’s business, or the location of partitions,
trade fixtures, or other contents of the Premises, or if any such changes, modifications,
alterations, additional sprinkler heads or other equipment become necessary to prevent the
imposition of a penalty or charge against the full allowance for a sprinkler system in the fire
insurance rate as fixed by said Exchange, or by any fire insurance company, Tenant shall, at the
Tenant’s expense, promptly make and supply such changes, modifications, alterations, additional
sprinkler heads or other equipment.

     Tenant shall not overload the floors, nor shall Tenant install any heavy business machines or
any safes or heavy equipment of any kind without prior written consent of Landlord, which if
granted, may be conditioned upon moving by skilled licensed handlers, and installation and
maintenance at Tenant’s expense of special reinforcings and settings adequate to carry the
additional weight and to absorb and prevent noise and vibration.

6.0 REPAIRS BY LANDLORD

     Landlord shall have no duty to Tenant to make any repairs or improvements to the Premises
except such repairs as may be deemed necessary by Landlord for normal maintenance operations of the
Building’s plumbing, heating and air-conditioning and electrical systems, Building parking lots and
grounds, and such structural repairs necessary for safety and tenantability and then only if not
brought about by any act or neglect of Tenant, its agents,

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employees or visitors. Tenant agrees to report immediately in writing to Landlord any
defective condition in or about the Premises known to Tenant, and a failure to so report shall make
Tenant liable to Landlord for any expense or damage to Landlord resulting from such defective
condition. Landlord shall have the right of full access to the Premises (including entry by use of
master key) to make repairs without reduction or abatement of rent.

7.0 INSURANCE AND INSURANCE RATES

     Landlord shall carry fire, casualty and liability insurance insuring its interest in the
Building and the Premises. Tenant shall carry fire, casualty and liability insurance insuring its
interest, if any, in improvements to or in the Premises and its interest in its office furniture,
equipment, supplies and other property. Tenant hereby waives any claim or right of action which it
may have against Landlord for loss or damage covered by such insurance, and Tenant covenants and
agrees that it will obtain a waiver from the carrier of such insurance releasing such carrier’s
subrogation rights as against Landlord. Tenant shall maintain a comprehensive liability policy
covering loss to person or property (a) in the amount of One Million and No/100 Dollars
($1,000,000) bodily injury per person, and One Hundred Thousand and No/100 Dollars ($100,000)
property damage, or (b) in the amount of Three Million and No/100 Dollars ($3,000,000) single limit
for bodily injury and property damage. Such policies shall name Landlord as an insured. Tenant
shall furnish Landlord a certificate of insurance indicating (a) current coverage during the term
of this Lease, and (b) a provision requiring a thirty (30) day prior notice to the Landlord of
cancellation.

     Tenant shall not do or cause to be done or permit on the Premises or in the Building anything
deemed extra hazardous on account of fire, and Tenant shall not use the Premises or the Building in
any manner which will cause an increase in the premium rate for any insurance in effect on the
Building or a part thereof. If, because of anything done by Tenant, the premium rate for any kind
of insurance in effect on the Building or any part thereof shall be raised, Tenant shall pay
Landlord the amount of any such increase in premium in accordance with the provisions of this
Lease. If Landlord shall demand that Tenant remedy the condition which caused any such increase in
an insurance premium rate, Tenant shall remedy such condition within five (5) days after receipt of
such demand.

8.0 FIRE OR OTHER CASUALTY

     In the event that before or during the term of this Lease, the Premises shall be damaged by
fire or other casualty which in the opinion of Landlord does not render the Premises or a part
thereof untenantable Landlord will, at its option (subject to the other provisions of this Section
8.0), repair the same with reasonable dispatch upon receipt of written notice of the damage from
Tenant, and there shall be no abatement of the rent.

     In the event that before or during the term of this Lease the Premises or the Building shall
be damaged by fire or other casualty which in the opinion of the Landlord renders the Building, the
Premises or any part of the Building or Premises untenantable, Landlord within twenty (20) days of
notice of such fire or casualty or of receipt of written notice from Tenant of such damage
(whichever shall last occur) shall have the right to and shall either (i) serve written notice upon
Tenant of Landlord’s intent to repair said damage or (ii) if in Landlord’s opinion said damage

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renders so much of either of the Premises or of the Building untenantable that repair would
not be advisable, serve written notice upon Tenant that this Lease is terminated. If Landlord shall
elect to terminate this Lease aforesaid, such termination shall be effective immediately upon
service of such notice by Landlord upon Tenant if the term shall not have commenced or on the date
specified in such notice if during the term. In the event of such termination the rent shall be
apportioned and paid up to the time of such fire or other casualty if the Premises are rendered
wholly untenantable as aforesaid by such fire or other casualty or up to the specified date of
termination if the Premises are not rendered wholly untenantable by such fire or other casualty.
Any obligation of Tenant to Landlord for any sum of money due under any provisions of this Lease
shall survive any such termination of this Lease by Landlord. If, on the other hand, Landlord shall
elect to repair such damage, such repairs shall be commenced within forty-five (45) days of notice
to Tenant of such election and the Landlord shall diligently proceed with such restoration,
however, Landlord’s obligation to repair or rebuild shall be limited to the availability of
insurance proceeds. During the period of repair the total amount of the rent provided for in
Article 2.0 of this Lease shall be reduced to an amount which in Landlord’s opinion bears the same
ratio to the rent provided for in said Article 2.0 as the portion of the Premises then available
for use bears to the entire Premises. Upon completion of such repair, the rent shall thereafter be
paid as if no fire or other casualty had occurred.

     Notwithstanding the foregoing, in the event that before or during the term of this Lease the
Premises or the Building shall be damaged by fire or other casualty which shall have been
occasioned by the act of Tenant or of its servants, agents, visitors, invitees or licensees, (i)
there shall be no apportionment or abatement of the rent and, (ii) Landlord shall have the right
but shall have no obligation to repair the Premises or the Building, and (iii) Tenant shall
reimburse and compensate Landlord within five (5) days of rendition of any statements to Tenant by
Landlord for any expenditures made by Landlord in making any such repairs. Any such actions shall
be without prejudice to any other rights and remedies of Landlord and without prejudice to any
rights of subrogation of any insurer of Landlord.

     The other provisions of this Article 8.0 notwithstanding, Landlord shall have no obligation to
replace or repair any property in the Building or on the Premises belonging to Tenant or to anyone
claiming through or under Tenant, nor shall Landlord have any obligation hereunder to replace or
repair any property on the Premises which Landlord may require Tenant to remove from the Premises.

9.0 WAIVER OF CERTAIN CLAIMS

     The Tenant, to the extent permitted by law, waives all claims it may have against the
Landlord, and against the Landlord’s agents and employees for damage to person or property
sustained by the Tenant or by any occupant of the Premises or by any other person, resulting from
any part of the Property or any equipment or appurtenances becoming out of repair, or resulting
from any accident in or about the Property or resulting directly or indirectly from any act or
neglect of any tenant or occupant of any part of the Property or of any other person, unless such
damage is a result of the negligence or contributory negligence of Landlord, or Landlord’s agents
or employees. If any damage results from any act or neglect of the Tenant, the Landlord may, at the
Landlord’s option, repair such damage and the Tenant shall thereupon pay to the Landlord the total
cost of such repair. All personal property belonging to the Tenant or any

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occupant of the Premises that is in or on any part of the Property shall be there at the risk
of the Tenant or of such other person only, and the Landlord, its agents and employees shall not be
liable for any damage thereto or for the theft or misappropriation thereof unless such damage,
theft or misappropriation is a result of the negligence or contributory negligence of Landlord or
Landlord’s agents or employees. The Tenant agrees to hold the Landlord harmless and to indemnify
the Landlord against claims and liability for injuries to all persons and for damage to or loss of
property occurring in or about the Property, due to any act of negligence or default under this
Lease by the Tenant, its agents or employees.

     To the extent that the Tenant carries hazard insurance on any of its property in the Premises
and to the extent that the Landlord carries hazard insurance on the Property, each policy of
insurance shall contain (if obtainable from the insurer selected by the Tenant or the Landlord, as
the case may be, without additional expense) a provision waiving subrogation against the other
party to this Lease. If such provision can be obtained only at additional expense, the obligation
to obtain such provision shall be effective only if the other party, on notice shall pay the amount
of such additional expense. Each of the parties hereto releases the other with respect to any
liability which the other may have for any damage by fire or other casualty with respect to which
the party against whom such release is claimed shall be insured under a policy or policies of
insurance containing such provision waiving subrogation.

10.0 PARKING

     Landlord shall have the right to change the area, level, location and arrangement of and
number of parking areas, as well as the number of parking spaces, and to restrict parking areas
with a view toward improving the convenience and use thereof by the Tenant, its customers and
employees. The Landlord presently provides a total of five hundred fifty-two (552) parking spaces
for this Building. Based on the Tenant’s proportionate share of space in the Building of three and
forty-nine one hundredths percent (3.49%), the same proportionate share as found in Article 2.02.01
OPERATING EXPENSES and Article 2.02.02 REAL ESTATE TAXES), the Tenant is entitled to of three and
forty-nine one hundredths percent (3.49%) of the parking spaces, which percentage shall increase in
direct proportion to any additional space leased by the Tenant.

     Subject to the other provisions of this Lease, Tenant shall have free non-exclusive use of
parking facilities, driveways and islands for Tenant, Tenant’s employees, Tenant’s business
invitees and Tenant’s agents. Such areas for non-exclusive parking spaces shall serve all tenants,
their employees, business invitees and agents. (Tenant shall, upon written notice from Landlord,
within five (5) days, furnish Landlord, or its authorized agent, the state motor vehicle license
number assigned to each of its motor vehicles to be parked on the Property and the motor vehicle of
all of its employees to be employed on the Premises). Tenant shall not at any time park any truck
or delivery vehicles in any parking areas or driveways, except as specifically designated by
Landlord from time to time, and shall confine all truck parking, loading and unloading to times and
locations specifically designated by Landlord from time to time. Tenant shall require all trucks
servicing Tenant to be promptly loaded or unloaded and removed from the Property. Tenant covenants
and agrees to enforce the provisions of this Lease against Tenant’s employees and business
invitees. Landlord shall have the right, but not the obligation: (a) to police said parking
facilities, (b) to provide parking attendants, (c) to change the area, level, location and

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arrangement of parking areas, (d) to cause unauthorized motor vehicles to be towed away at the
sole risk and expense of the owner of such motor vehicles, (e) to provide for such exclusive use as
Landlord may determine from time to time, for the exclusive use of the handicapped, and/or for the
exclusive use of visitors, (f) to use any portion of the parking facilities from time to time
and/or to deny access to the same temporarily to repair, maintain or restore such facilities or to
construct improvements under, over, along, across and upon the same for the benefit of the Property
and to grant easements therein to public and quasi-public authorities, and (g) to adopt and modify
from time to time rules and regulations for parking and ingress, egress, speed, no parking, no
standing, and for times and places for move in, move out and deliveries.

11.0 RIGHT OF ENTRY

     Landlord shall have the right to enter and to grant licenses to enter the Premises at any time
and for such lengths of time as Landlord shall deem reasonable without reduction or abatement of
rent (a) to inspect the Premises, (b) to exhibit the Premises to prospective tenants or purchasers
of the Building, (c) to make alterations or repairs to the Premises or the Building and to
temporarily store materials, tools and equipment for such alterations or repairs for any purpose
which Landlord shall deem necessary for the operation and maintenance of the Building and the
general welfare and comfort of its tenants.

     Landlord shall have the right to enter and to grant licenses to enter the Premises at any time
and for such lengths of time as Landlord shall deem reasonable without reduction or abatement of
rent for the purposes (a) of removing from the Premises any placards, signs, fixtures, alterations
or additions not permitted by this agreement or by the Rules and Regulations, (b) of abating any
condition which constitutes a violation of any covenant or condition of this Lease or of the Rules
and Regulations, and (c) of an emergency. No such entry by Landlord shall in any manner affect
Tenant’s obligations and covenants under this Lease, and no such entry shall of itself render
Landlord liable for any loss of or damage to the property of Tenant.

12.0 QUIET ENJOYMENT; SUBORDINATION AND ATTORNMENT

     If Tenant promptly and punctually complies with each of its obligations hereunder, it shall
peacefully have and enjoy the possession of the Premises during the term hereof. No action of
Landlord in other space in the Building, or in repairing or restoring the leased space, however,
shall be deemed a breach of this covenant, or give Tenant any right to modify this Lease either as
to term, rent payable, or other obligations to perform.

     This Lease is and shall continue to be subject and subordinate to any mortgages or deeds of
trust which may now or hereafter cover or affect the land on which the Building is constructed or
the Building, and to all renewals, modifications, consolidations, replacements and extensions of
any such mortgages or deeds of trust. This clause shall be self-operative and no further instrument
of subordination shall be required. At anytime and from time to time, however, Tenant shall execute
within five (5) days after receipt any certificate in confirmation of such subordination that
Landlord may request.

     If any such mortgage or deed of trust is terminated or foreclosed, this Lease (at the option
of the purchaser at such foreclosure sale) shall not terminate, nor be terminable by Tenant by

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reason of such foreclosure, and Tenant shall, if requested, attorn to the purchaser at such
foreclosure sale.

13.0 DEFAULT

     13.01 Anyone of the following events shall constitute an “Event of Default:”

     1. if Tenant shall fail to pay any monthly installment of Annual Rent, any Additional Rent or
any other sum payable by the Tenant when such sum is due in accordance with the terms of this
Lease; or

     2. if Tenant shall fail to keep or perform or abide by any other term, condition, covenant or
agreement of this Lease (whether or not specified herein as an Event of Default) or of the Rules
and Regulations now in effect or hereafter adopted and such default shall continue for a period
often (10) days after notice to Tenant of such default; or

     3. if (a) Tenant (or, if Tenant is a partnership, if any partner in Tenant) shall file a
petition in bankruptcy or consent to any other action seeking any such judicial decree or shall
make any assignment for the benefit of its creditors or shall admit in writing its inability to pay
its debts generally as they become due or if (b) any court of competent jurisdiction shall enter a
decree or order approving a petition filed against it or appointing any trustee or receiver for
Tenant or if any person shall file a petition for involuntary bankruptcy against Tenant and such
appointment or petition shall not be stayed or vacated within sixty (60) days or entry thereof; or

     4. if Tenant’s interest in this lease or the Premises shall be subjected to any attachment,
levy or sale pursuant to any order or decree entered against Tenant in any legal proceeding and
such order or decree shall not be vacated within fifteen (15) days of entry thereof; or

     5. the Premises are deserted, vacated, or not used regularly or consistently as would normally
be expected for similar premises put to the same or similar purposes, even though the Tenant
continues to pay all rental and charges provided for herein.

     13.02 If there is an “Event of Default,” Landlord, without declaring a termination of the
Lease (which right is, however, unconditionally and absolutely reserved) may at its sole election
exercise any one or more or all of the following remedies, in addition to any other remedies
Landlord may have under this Lease or at law or in equity:

     1. Landlord may re-enter the Premises and correct or repair any condition which shall
constitute a failure on Tenant’s part to keep or perform any covenant of this Lease or the Rules
and Regulations, and Tenant shall reimburse Landlord any expenditure made to make such correction
or repair.

     2. Landlord may, without terminating this Lease, demand that Tenant vacate the Premises and
remove all property belonging to Tenant, and Landlord shall have the right to re-enter and take
possession of the Premises without such entry and possession relieving the Tenant, in whole or in
part, from the Tenant’s obligation to pay the rent due hereunder for the full term of the Lease.
Any and all property which may be removed from the Premises by

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Landlord pursuant to this section or at law, to which Tenant is or may be entitled, may be
handled, removed or stored by landlord at risk, cost and expense of Tenant, and Landlord shall in
no event be responsible for the value, preservation or safekeeping thereof. Tenant shall pay to
Landlord upon demand any and all expenses incurred in such removal and all storage charges against
such properties so long as the same shall be in Landlord’s possession or under Landlord’s control.
Tenant agrees that to the fullest extent permitted by law any such property of Tenant not retaken
from storage by Tenant within thirty (30) days after the end of the term, however terminated, maybe
disposed of by Landlord in any manner whatsoever, including without limitation, the sale, scrapping
of and/or destruction thereof without any further obligation to Tenant, and Tenant shall pay to
Landlord promptly on demand reasonable expenses of such disposal.

     3. Landlord may at any time, without terminating this Lease, re-enter the Premises and remove
therefrom Tenant and all property belonging to or placed on the Premises by Tenant.

     4. Landlord without terminating this Lease may re-let the Premises at any rental as the
Landlord in its sole discretion deems advisable and Tenant shall pay all costs of such re-letting,
including but not limited to, any necessary alterations, repairs, and the difference, if any,
between the rent collected by any subsequent tenant and the rental provided under this Lease.

     5. The Landlord may elect to terminate this Lease. In such event, Tenant shall remain liable
to Landlord for damages, due and payable monthly on the day rent would have been payable hereunder,
and in the amount equal to the rent and any other amounts which would have been owing by Tenant for
the balance of the term of the lease, had this Lease not been terminated, less the net
proceeds, if any, of any re-letting of the Premises by Landlord, after deducting all of the
Landlord’s costs associated with the termination of the Lease (including but not limited to legal
expenses and attorneys’ fees), and the cost to repair or alter the Premises incurred in connection
or in any way related to the termination of this Lease, eviction of Tenant and such re-letting.

     6. Landlord may recover from Tenant all costs associated with the termination of this Lease or
other remedial measures herein provided or provided by law, including but not limited to, legal
expenses and attorneys’ fees, the cost to repair or alter the Premises, and all loss of rents the
Landlord may incur by reason of such termination.

     7. Landlord may declare the entire amount of rent calculated on current rent being paid by
Tenant and Additional Rent which in Landlord’s reasonable determination would become due and
payable during the remainder of the term of the Lease, discounted to present value by using a
reasonable discount rate selected by Landlord, to be due and payable immediately. Upon acceleration
of such amounts, Tenant agrees to pay the same at once, together with all rent and other amounts
theretofore due, at Landlord’s address as provided herein. Such payment shall not constitute a
penalty or forfeiture but shall constitute liquidated damages for Tenant’s failure to comply with
the terms and provisions of this Lease (Landlord and Tenant agreeing that Landlord’s actual damages
in such an event are impossible to ascertain and that the amount set forth above is a reasonable
estimate thereof).

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     13.03 In the event of any re-entry of the Premises by Landlord pursuant to any of the
provisions of this Lease, Tenant hereby waives all claims for damages which may be caused by such
re-entry by Landlord, and Tenant shall save Landlord harmless from any loss, cost (including legal
expenses and reasonable attorneys’ fees) or damages suffered by Landlord by reason of such
re-entry. No such re-entry shall be considered or construed to be a forcible entry.

     13.04 No course of dealing between Landlord and Tenant or any delay on the part of Landlord in
exercising any rights it may have under this Lease shall operate as a waiver of any of the rights
of Landlord hereunder, nor shall any waiver of a prior default operate as a waiver of any
subsequent default or defaults. No express waiver shall affect any condition, covenant, rule or
regulation other than the one specified in such waiver and that one only for the time and in the
manner specifically stated.

     13.05 The exercise by Landlord of any one or more of the remedies provided in this Lease shall
not prevent the subsequent exercise by Landlord of any one or more of the other remedies herein
provided or provided by law. All remedies provided for in this Lease are cumulative and may, at the
election of Landlord, be exercised alternatively, successively or in any other manner and are in
addition to any other rights provided by law.

     13.06 Landlord, to the fullest extent permitted by law, shall have a lien on and the Tenant
hereby grants Landlord a security interest in all of the equipment, wares, chattels, fixtures,
furniture and other property of Tenant which may be in or upon the Premises, the Building or the
Property. Tenant hereby specifically, to the fullest extent permitted by law, waives any and all
exemptions allowed by law, and such lien and security interest may be enforced upon the nonpayment
of any installment of rent, Additional Rent or other moneys due and payable hereunder by the taking
and selling of such property subject to at least fifteen (15) days advance written notice, or such
lien may be enforced in any lawful manner at the option of Landlord.

     13.07 Tenant shall pay upon demand all Landlord’s costs, charges and expenses, including the
fees of counsel, agents and others retained by Landlord, incurred in enforcing its obligations
hereunder or incurred by Landlord in any litigation, negotiation or transaction which Tenant causes
Landlord, without Landlord’s fault to become involved or concerned.

     13.08 MULTIPLE DEFAULTS: (a) Tenant acknowledges that any rights or options of first refusal,
or to extend the Term, to expand the size of the Premises, to purchase the Premises or the
Building, or other such or similar rights or options which have been granted to Tenant under this
Lease are conditioned upon the prompt and diligent performance of the terms of this Lease by
Tenant. Accordingly, should Tenant default under this Lease on two (2) or more occasions during any
twelve (12) month period, in addition to all other remedies available to Landlord, all such rights
and options shall automatically, and without further action on the part of any party, expire and be
deemed canceled and of no further force and effect.

          (b) Should Tenant default in the payment of Rent, Additional Rent, or any other sums payable
by Tenant under this Lease on two (2) or more occasions during any twelve (12) month period,
regardless of whether any such default is cured, then, in addition to all other remedies otherwise
available to Landlord, Tenant shall, within ten (10) days after demand by

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Landlord, post a security deposit in, or increase the existing Security Deposit by, a sum
equal to three (3) months’ installments of Rent. Any security deposit posted pursuant to the
foregoing sentence shall be governed by Section 2.03.

     (c) Should Tenant default under this Lease on two (2) or more occasions during any twelve (12)
month period, in addition to all other remedies available to Landlord, any notice requirements or
cure periods otherwise set forth in this Lease with respect to a default by Tenant shall not apply.

14.0 NO ESTATE IN LAND

     This Lease shall create only the relationship of landlord and tenant between Landlord and
Tenant.

15.0 INVALIDITY OF PARTICULAR PROVISIONS

     If any clause or provision of this Lease is or becomes illegal, invalid, or unenforceable
because of present or future laws or any rule or regulation of any governmental body or entity,
effective during its term, the intention of the parties hereto is that the remaining parts of this
Lease shall not be affected thereby unless such invalidity is, in the sole determination of
Landlord, essential to the rights of both parties, in which event Landlord has the right to
terminate this Lease on written notice to Tenant.

16.0 SUBSTITUTE PREMISES

     The Landlord shall have the right at any time during the term hereof, upon giving Tenant not
less than sixty (60) days prior written notice, to provide and furnish Tenant with space elsewhere
in the Building of approximately the same size as the Premises and remove and place Tenant in such
space, with Landlord to pay all reasonable costs and expenses incurred as a result of such removal
of Tenant. Should Tenant refuse to permit Landlord to move Tenant to such new space at the end of
said sixty (60) day period, Landlord shall have the right to cancel and terminate this Lease
effective ninety (90) days from the date of original notification by Landlord. If Landlord moves
Tenant to such new space, this Lease and each and all of its terms, covenants and conditions shall
remain in full force and effect, subject however, to the adjustment of rent to account for any
difference in square footage, with such adjustment to be made on a per square foot basis.

17.0 TENANT’S PERSONAL PROPERTY TAXES

     Tenant shall pay prior to the delinquency all taxes assessed against or levied upon its
occupancy of the Premises, or upon the fixtures, furnishings, equipment and all other personal
property of Tenant located in the Premises. Tenant shall cause said fixtures, furnishings,
equipment and other personal property to be assessed and billed separately from the property of
Landlord. In the event any or all of Tenant’s fixtures, furnishings, equipment and other personal
property, shall be assessed and taxed as the property of Landlord, Tenant shall pay to Landlord its
share of such taxes within ten (10) days after delivery to Tenant by Landlord of a statement in
writing setting forth the amount of such taxes applicable to Tenant’s fixtures, furnishings,
equipment or personal property.

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18.0 NOTICES AND CONSENTS

     All notices, demands, requests, consents or approvals which may or are required to be given by
either party to the other shall be in writing and shall be deemed given when sent by United States
Certified or Registered Mail, Return Receipt Requested, postage prepaid, (a) if for the Tenant,
addressed to the Tenant at the Building, or at such other place as the Tenant my from time to time
designate by written notice to the Landlord, or(b) if the Landlord, addressed to the office of the
Landlord at 3700 Regency Parkway, Suite 100, Cary, North Carolina 27511, with a copy to Landlord’s
attorney addressed to Womble Carlyle Sandridge & Rice, P.L.L.C., Attention: Mr. Leslie Browder, P.
O. Drawer 84, Winston-Salem, North Carolina 27102, or at such other place as the Landlord may from
time to time designate by written notice to the Tenant. All consent and approvals provided for
herein must be in writing to be valid. If the term “Tenant” as used in this Lease refers to more
than one person, any notice, consent, approval, requests, bill, demand or statement, given as
aforesaid to any one of such persons shall be deemed to have been duly given to Tenant.

     Except as specifically provided in this Lease, Tenant hereby expressly waives the service of
intention to terminate this Lease or to re-enter the Premises and waives the service of any demand
for payment of rent or for possession and waives the services of any other notice or demand
prescribed by any statute or other law.

19.0 CONDEMNATION

     19.01 If the whole or more than twenty-five percent (25%) of the Building shall be taken by
condemnation, this Lease shall terminate on the date possession of the Building is required to be
surrendered to the condemnor, and rent payable hereunder shall be prorated through such date.

     19.02 If less than twenty-five percent (25%) of the Building shall betaken by condemnation,
this Lease shall, at the option of the Landlord, terminate only as to the part of the Premises so
taken, but shall continue in full force as to the part of the Premises not taken. In the event of
such partial taking and the continuance of this Lease for the part not so taken, then Landlord
shall, at its cost and expense, forthwith repair and restore the Building to as nearly as possible
their condition immediately prior to such taking. Notwithstanding the above, Landlord’s obligation
to restore shall be limited to the availability of any condemnation awards. From the date of the
surrender of possession to the condemnor to the date of the completion of the repairs and
restoration of the portion of the Building not so taken, there shall be no abatement of the rent,
except for the portion of the Premises, if any, that shall not be usable for Tenant’s business.

     19.03 After the repairs and restoration have been completed following the partial taking, the
rent for the unexpired term shall not be reduced unless the particular taking includes a part of
the Premises and, in such event, the rent for the unexpired term shall be reduced by that portion
which the area so taken shall bear to the entire area of the Premises immediately prior to such
taking.

     19.04 Tenant agrees that if the Premises or any part thereof shall be taken by condemnation,
Tenant shall have no claim against the Landlord and shall not have any claim or

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right to any portion of the amount that may be awarded as damages or paid as a result of such
condemnation.

20.0 ASSIGNMENT-SUBLEASE

     Tenant shall not, without the prior written consent of Landlord, assign, hypothecate, encumber
or otherwise transfer this Lease or any interest hereunder, or sublet the Premises or any part
thereof, or permit the use of the Premises by any party other than Tenant.

     If Tenant desires to sublease the Premises or any part thereof, Tenant shall submit to
Landlord a written request for the consent of Landlord to such subletting, which request shall be
accompanied by the name and address of the proposed subtenant, a description identifying the space
to be sublet, a copy of the fully executed sublease conditioned only upon approval of Landlord, the
nature and character of the business of the proposed subtenant, and its proposed use of the
Premises, current financial information on the proposed subtenant and such other information as
Landlord may request.

     Consent to any assignment or sublease shall not be unreasonably withheld. The Tenant
acknowledges that Landlord is entitled to withhold its consent in the event the nature and
character of the business of the proposed tenant, its proposed use of the Premises or the financial
condition of the proposed tenant is objectionable or unsatisfactory to Landlord. Any Landlord
consent to an assignment or sublease shall not nullify this provision, and all later assignments or
subleases shall be made likewise only after the prior written consent of Landlord is obtained in
each instance. Unless otherwise expressly agreed to by Landlord in writing, no sublease or
assignment by Tenant shall relieve Tenant of any liability hereunder. Tenant acknowledges and
agrees that Landlord may condition its consent to any proposed assignment or sublease upon the
agreement of Tenant to pay to Landlord the excess, if any, of the rentals and other charges to be
paid by Tenant’s assignee or sublessee under the terms and provisions of such proposed assignment
or sublease over the Annual Rent and Additional Rent and other charges to be paid by Tenant to
Landlord hereunder. The occupancy of the Premises by any successor firm of the Tenant or by any
firm into which or with which the Tenant may become merged or consolidated shall be deemed an
assignment of this Lease requiring the prior written consent of Landlord. Notwithstanding the
giving by Landlord of its consent to any assignment or sublease with respect to the Premises, no
such assignee or sublessee may exercise any expansion option, right of first refusal option, or
renewal option under this Lease except in accordance with a separate written agreement entered into
directly between such assignee of sublessee and Landlord.

     In no event shall Tenant (1) advertise or publicize in any way the availability of all or part
of the Premises without the prior written consent of the Landlord, or (2) advertise or publicize
the Premises for subletting whether through a broker, agent, representative or otherwise at a
rental rate less than that for which space in the Building is being offered for rent by Landlord.
Tenant agrees to pay to Landlord, on demand, all reasonable costs (including attorneys’ fees)
incurred by Landlord in connection with any request by Tenant for Landlord’s consent to any
assignment or subletting.

     Landlord may assign this Lease to any construction or permanent mortgagee (“Mortgagee”) of the
Property as additional security for the payment of any loan thereby

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secured. If the Tenant shall have received notice from Landlord or Mortgagee of any such
assignment, Tenant shall thereafter give written notice of any breach or failure of performance by
Landlord under this Lease to Mortgagee and allow Mortgagee a reasonable period of time to remedy
the same. Any breach or failure of performance by Landlord hereunder shall not constitute a default
as between Landlord and Tenant until such notice shall have been given.

     Landlord, or its successors and assigns, may assign this Lease to a subsequent purchaser of
the Property without the consent or approval of this Tenant, assignee or sublessee.

     20.01 BANKRUPTCY: Landlord and Tenant understand that, notwithstanding certain provisions to
the contrary contained herein, a trustee or debtor in possession under the United States Bankruptcy
Code as amended (the “Code”), may have certain rights to assume or assign this Lease. Landlord and
Tenant further understand that, in any event, pursuant to the Code, Landlord is entitled to
adequate assurances of future performance of the provisions of this Lease. The parties agree that,
with respect to any such assumption or assignment out of bankruptcy, the term “adequate assurance”
shall include at least the following:

          (a) In order to assure Landlord that the proposed assignee will have the resources with which
to pay all Rent payable pursuant to the provisions of this Lease, any proposed assignee must have,
as demonstrated to Landlord’s satisfaction, a net worth (as defined in accordance with generally
accepted accounting principles consistently applied) of not less than the net worth of Tenant on
the Commencement Date, increased by seven percent (7%), compounded annually, for each year from the
Commencement Date through the date of the proposed assignment. It is understood and agreed that the
financial condition and resources of the Tenant were a material inducement to the Landlord in
entering into this Lease.

          (b) Any proposed assignee must have been engaged in the conduct of business for the five (5)
years prior to any such proposed assignment, which business does not violate the use permitted
under Section 3.0 above and such proposed assignee shall continue to engage in such use. It is
understood that Landlord’s asset will be substantially impaired if the trustee in bankruptcy or any
assignee of this Lease makes any use of the Premises other than such permitted use.

          (c) Any proposed assignee of this Lease must assume and agree to be personally bound by the
provisions of this Lease.

21.0 HOLDING OVER

     In the event Tenant remains in possession of the Premises subsequent to the expiration or
other termination of this Lease and without regard to Landlord’s acquiescence or consent, Tenant
shall pay as liquidated damages a monthly rent double the monthly rent payable immediately prior to
such expiration or termination of the Lease for the duration of such period. No such payment (or
the acceptance thereof) shall in any way constitute a waiver of the right of the Landlord to
dispossess the Tenant and recover possession or exercise any other remedy herein provided. If such
holding over is with the Landlord’s consent, the Tenant shall be a tenant on a month-to-month basis
which tenancy shall be terminated absolutely and without remedy upon

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thirty (30) days written notice of such intent by either party. There shall be no renewal of
this Lease by operation of law.

22.0 RULES AND REGULATIONS

     The Rules and Regulations in regard to the Building attached hereto as Exhibit F and
all rules and regulations which Landlord may hereafter from time to time adopt and promulgate for
the government and management of said Building (provided all such rules and regulations are
applicable to all tenants) are hereby made a part of this Lease and shall during the said Term be
in all things observed and performed by the Tenant and by the Tenant’s clerks, employees, servants
and agents. Tenant does hereby accept and agree to abide by and uphold the Rules and Regulations as
shown in Exhibit F. Insofar as the attached standard Rules and Regulations conflict with
any of the terms and provisions of this Lease Agreement, the terms and provisions of the Lease
shall control.

23.0 TIME IS OF THE ESSENCE

     Time is of the essence of this Agreement.

24.0 ESTOPPEL CERTIFICATES

     Within five (5) days after request therefor by Landlord or any mortgagee of the Property or
any prospective purchaser of the Premises, Tenant agrees to execute and deliver, in recordable
form, at any time or from time to time, an estoppel certificate addressed to any mortgagee or
proposed mortgagee or purchaser, of the Building, or addressed to the Landlord, certifying (if such
be the case) that this Lease is unmodified and in full force and effect (and if there have been any
modifications that the same is in full force and effect as modified and stating said
modifications); stating that there are no defenses, defaults, or offsets against the enforcement of
this Lease or stating those claimed by Tenant; stating that rent has commenced to accrue, and that
Tenant has accepted and is occupying the Premises; stating the date to which rentals and other
charges are paid; and as to mortgagees or prospective mortgagees, agreeing that in the event the
mortgagee becomes owner of the Premises or exercises an assignment of rents granted mortgagee by
the Landlord, the Tenant will accept and attorn to the mortgagee or to a party designated by said
mortgagee as its direct tenant, and that the mortgagee will not be bound by or responsible for any
rents paid in advance to Landlord or offsets against Tenant or any prior defaults of the Tenant and
that thereafter all notices required or permitted under the Lease be given to Landlord shall
thereafter be given to said mortgagee. Such certificates shall also include such other information
as may be reasonably required by any mortgagee.

25.0 EVENTS BEYOND CONTROL OF LANDLORD AND TENANT

     Landlord and/or Tenant shall be excused for the period of any delay and shall not be deemed in
default with respect to the performance of any of the terms, covenants, and conditions of this
Lease when prevented from so doing by a cause or causes beyond the Landlord and/or Tenant’s
control, which shall include, without limitation, all labor disputes, governmental regulations or
controls, fire or other casualty, inability to obtain any material or services, acts of God, or any
other cause, except the obligation of the Tenant under this Lease to make prompt payment to
Landlord of the rental payments and all other charges due hereunder.

- 21 -

 

26.0 SIGNS

     Tenant may not erect, install or display any sign or advertising material upon the Premises
and Building, the walls thereof, of in any window therein, without prior written consent of
Landlord. Landlord shall furnish, install and maintain a building directory at a convenient
location in the lobby listing the name of Tenant and the room number of Tenant’s entrance office
and shall furnish and install any approved sign for Tenant, the cost of which shall be charged to
the Tenant.

     The Tenant shall not use the name “REGENCY PARK” or its logo unless the Landlord should grant
its prior written consent thereto.

27.0 BROKERAGE

     Tenant represents and warrants that it has dealt with no broker, agent or other person in
connection with this transaction and that no broker, agent or other person brought about this
transaction, other than REGENCY PARK CORPORATION. Tenant agrees to indemnify and hold Landlord
harmless from and against any claims by any other broker, agent or other person claiming a
commission or other form of compensation by virtue of having dealt with Tenant with regard to this
leasing transaction. The provisions of this section shall survive the termination of this Lease.

28.0 RECORDATION OF LEASE

     The Tenant will not record this Lease. Upon the request of either party hereto, the other
party will join in the execution of a Memorandum of Lease for the purposes of recordation in the
Office of the Register of Deeds, Wake County, North Carolina. The Memorandum will be approved as to
form by the Landlord and will describe only the parties, the Premises, the term and any options to
renew the term.

29.0 GOVERNMENTAL COMPLIANCE

     Tenant covenants and agrees to make use of the Premises in accordance with all municipal,
county, state and federal laws, rules and regulations, including, but not limited to environmental
laws, rules and regulations, and all permitting, licensing and other governmental approvals now or
hereafter implemented. Tenant further covenants and agrees neither to cause nor permit any
hazardous or toxic waste or materials (as defined by state and federal laws, rules and regulations)
to be stored at or upon the Premises, the Building and Property nor to cause nor permit any such
material or waste to be disposed of at the Premises or under or within the Building and Property.
Tenant will hold Landlord harmless for all costs, expenses, fines, charges (including attorneys’
and engineers’ fees and charges) incurred by Landlord as a direct or indirect expense caused by the
breach of this Article by Tenant, its employees, agents and invitees, and further covenants and
agrees to, at all times, include specific coverage to such effect as a part of Tenant’s public
liability insurance coverage.

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30.0 HAZARDOUS MATERIALS

     Tenant shall not (either with or without negligence) cause or permit the escape, disposal or
release of any biologically or chemically active or other hazardous substances or materials. Tenant
shall not allow the storage or use of such substances or materials in any manner not sanctioned by
law or by the highest standards prevailing in the industry for the storage and use of such
substances or materials, nor allow to be brought onto the Property any such materials or substances
except to use in the ordinary course of Tenant’s business, and then only after written notice is
given to Landlord of the identity of such substances or materials. Without limitation, hazardous
substances and materials shall include those described in the Comprehensive Environmental Response
Compensation and Liability Act of 1980, as amended, 42 U.S.C. Section 9601 et seq., any applicable
state or local laws and the regulations adopted under these acts. If any lender or governmental
agency shall ever require testing to ascertain whether or not there has been any release of
hazardous materials, then the reasonable costs thereof shall be reimbursed by Tenant to Landlord
upon demand as additional charges if such requirement applies to the Premises. In addition, Tenant
shall execute affidavits, representations and the like from time to time at Landlord’s request
concerning Tenant’s best knowledge and belief regarding the presence of hazardous substances or
materials on the Premises. In all events, Tenant shall indemnify Landlord in the manner elsewhere
provided in this Lease from any release of hazardous materials on the Premises occurring while
Tenant is in possession, or elsewhere if caused by Tenant or persons acting under Tenant. The
within covenants shall survive the expiration or earlier termination of the Lease term.

31.0 COMMON AREAS

     Tenant shall have the right, together with other tenants and occupants and invitees, to the
nonexclusive use of the sidewalks, driveways, stairways, halls, lobbies, elevators and passages in
the Building and on the Property for reasonable ingress to and egress from the Premises and for no
other purpose subject to the other provisions of this Lease, including, without limitation, the
Rules and Regulations set forth in Exhibit F.

32.0 POSSESSION

     On the expiration or other termination of the term of this Lease, Tenant shall quit and
surrender to Landlord the Premises, broom clean, in good order and condition, ordinary wear and
tear excepted, and Tenant shall remove all of its property except as provided in Article 5.
Tenant’s obligation to observe and perform this covenant shall survive the expiration and other
termination of the term of this Lease.

33.0 MISCELLANEOUS

     a. The words “Landlord” and “Tenant” wherever used in the Lease shall be construed to mean
plural where necessary, and the necessary grammatical changes required to make the provisions
hereof apply either to corporations or individuals, either men or women, shall in all cases be
assumed as though in each case fully expressed.

     b. Each provision hereof shall extend to and shall bind and inure to the benefit of Landlord
and Tenant and their respective heirs, legal representatives, assessors and assigns.

- 23 -

 

     c. Submission of this instrument for examination does not constitute a reservation of or
option for the Premises. The instrument does not become effective as a Lease or otherwise until
executed and delivered by both Landlord and Tenant.

     d. The headings of sections are for convenience only and do not limit or construe the contents
of the sections.

     e. Should any mortgagee require a modification or modifications of this Lease, which
modification or modifications will not bring about any increased cost or expense to Tenant or in
any way substantially change the rights and obligations of Tenant hereunder, then in such event,
Tenant agrees to execute such an amendment.

     f. The laws of the State of North Carolina shall govern the validity, performance and
enforcement of this Lease.

     g. This Lease contains the entire agreement of the parties in regard to the Premises. There
are no oral agreements existing between them, and there shall be no oral changes. Neither Landlord
nor any agent of Landlord has made any representations, warranties or promises with respect to the
Premises, the Building or the Property, or the use of any amenities or facilities except as
expressly set forth herein. Any agreement hereafter made shall be ineffective to change, waive,
modify, discharge or terminate the Lease in whole or in part unless such agreement is in writing
and signed by the party against whom enforcement of the change, waiver, modification, discharge or
termination is sought.

     h. The shareholders, directors and officers of Landlord (collectively the “Parties”) shall not
be liable for the performance of Landlord’s obligations under this Lease. Tenant shall look solely
to Landlord to enforce Landlord’s obligations hereunder and shall not seek any damages against the
rest of the parties. A liability of Landlord for Landlord’s obligations of this Lease shall not
exceed and shall be limited to a value of Landlord’s interest in the Property, and Tenant shall not
look to the property or assets of any of the Parties in seeking either to enforce Landlord’s
obligations under the Lease or to satisfy a judgment for Landlord’s failure to perform as such
obligation.

     Exhibits A, B, C, D, E, and F consisting of ten (10) pages are attached hereto and become part
of this Lease.

- 24 -

 

     IN WITNESS WHEREOF, Landlord and Tenant have respectively signed and sealed this Lease in
duplicate as the day and year first above written.

	 	 	 	 	 
	 	REGENCY PARK CORPORATION

Landlord

 	 
	 	By:  	/s/ Eric M. Salomon
 	 
	 	 	Vice President/Treasurer 	 
	 	 	 	 
	 

	 	 	 	 	 
	 	(CORPORATE SEAL)

ATTEST:

 	 
	 	/s/ Angela Barton
 	 
	 	Angela Barton 	 
	 	Assistant Secretary 	 
	 

	 	 	 	 	 
	 	CORNERSTONE BIOPHARMA, INC

Tenant

 	 
	 	By:  	/s/ Chenyqua Baldwin
 	 
	 	Title:  	Chief Financial Officer 	 
	 	 	 	 
	 

(CORPORATE SEAL)

ATTEST

           
                     
                     
                           

                                        Secretary

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EXHIBIT A

- 26 -

 

 

- 27 -

 

EXHIBIT C

SCHEDULE 3

TENANT FIT-UP

	 	1.	 	The Landlord shall recarpet the Premises at its cost.
	 
	 	2.	 	The Landlord shall repaint the Premises at its cost.
	 
	 	3.	 	The Landlord shall build out the office space in accordance with the plans
provided by IS Design and agreed to between Landlord and Tenant.

The Landlord shall not be responsible for any Tenant furniture, fixtures or equipment, including,
but not limited to data communication wiring, or phones, phone connectors, network or dedicated
connections in excess of code required for normal electrical plugs, or installation thereof.

- 28 -

 

EXHIBIT D

COMMENCEMENT DATE VERIFICATION

NORTH CAROLINA

WAKE COUNTY

     THIS
COMMENCEMENT DATE VERIFICATION, dated this
                    
day of                     , 2004, and
entered into between REGENCY PARK CORPORATION, a North Carolina corporation, as Landlord and                     
a North Carolina corporation, the Tenant.

W I T N E S S E T H:

     WHEREAS, the parties hereto entered into that certain Lease Agreement dated the                      day of
                    , 2004; and

     WHEREAS, the parties hereto are desirous of establishing the Commencement Date of the Lease
term provided for in said Lease Agreement.

     NOW, THEREFORE, the parties hereto do hereby mutually agree that the Commencement Date of the
hereinabove referred to Lease is the                      day of                     , 2004.

     IN TESTIMONY WHEREOF, the parties hereto have caused this instrument to be executed the date
first hereinabove set out.

	 	 	 	 	 
	 	 	REGENCY PARK CORPORATION
	 	 	Landlord
	 
	 	 	 	 
	 

	 	By:	 	 
	 

	 	 	 	 
	 

	 	 	 	Vice President/Treasurer
	 
	 	 	 	 
	 	 	 
	 	 	Tenant
	 
	 	 	 	 
	 

	 	By:	 	 
	 

	 	 	 	 
	 

	 	Title:	 	 
	 

	 	 	 	 

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EXHIBIT E

OPERATING EXPENSES

     “Operating Expenses” shall mean those items of cost and expenses paid or incurred by, or on
behalf of, Landlord for ownership security, maintenance, repair, management or operation of the
Building, adjacent sidewalks, the land upon which the Building is located, and the personal
property of Landlord used in the operation of the Building as determined in accordance with
generally accepted principles of sound management consistently applied, which are properly
chargeable to the operation of the Building, including but not limited to:

	 	1.	 	Landscaping and grounds maintenance costs and expenses, including those
attributable to the care and upkeep of the common areas of Regency Park generally and,
in addition, of Regency Park North, required of property owners; and any assessments
required to be paid by the owner of the Property to any other entity (including an
owner’s association for Regency Park generally and Regency Park North in particular).
Such payments may include any common area charges, annual assessments or any special
assessments to which the Owner is subject.
	 
	 	2.	 	Costs and expenses of redecorating, painting, and carpeting the common areas of
the Building and Property; provided, however, that, except as specified in Item 6
hereof, the cost of structural changes to the Building which should be capitalized in
accordance with sound accounting principles shall not be allocated or charged to the
Premises without Tenant’s approval.
	 
	 	3.	 	Costs of all repairs, alterations, additions, changes, replacements, and other
items required by any law or governmental regulation imposed after the date of this
Lease, regardless of whether such costs, when incurred, are classified as capital
expenditures.
	 
	 	4.	 	Costs of wages and salaries of all persons engaged in the operation,
maintenance, repair, and security of the Building and the Property, and so-called
fringe benefits, including social security taxes, unemployment insurance taxes, costs
for providing coverage for disability benefits, cost of any pensions, hospitalization,
welfare or retirement plans, or any other similar or like expense incurred under the
provisions of any collective bargaining agreement, costs of uniforms, and all other
costs or expenses that the Landlord pays to or on behalf of employees engaged in the
operation, maintenance, repair, and security of the Building and the Property.
	 
	 	5.	 	Legal and accounting expenses, including, but not limited to, such expenses as
relate to seeking or obtaining reductions in and/or refunds of real estate tax taxes.
	 
	 	6.	 	Amortization, with interest, of capital expenditures for capital improvements
made by Landlord after completion of the Building where such capital improvements are
for the purpose of, or result in, reducing Operating Expenses; provided, however, that
payments by Landlord of interest and principal on any
mortgage or similar instrument secured by the Property or the Building shall not 

- 30 -

 

	 		 	

be
included in Operating Expenses.

	 	7.	 	Landlord’s insurance costs and expenses for all types of insurance carried by
Landlord with respect to the Building and Property.
	 
	 	8.	 	costs of any health club facility that may from time to time be operated by
Regency Park Corporation, provided that Tenant is entitled to the nonexclusive use of
such health club facility.
	 
	 	9.	 	such other expenses paid by Landlord, from time to time, in connection with the
operation and maintenance of the Building and the Property as would be expected to be
paid by a reasonable and prudent operator and manager of a building and site comparable
to the Building and the Property.
	 
	 	10.	 	all costs of special services rendered to particular tenants of the Building,
which are paid by such tenants, shall not be included in Operating Expenses.

The Tenant acknowledges that the Landlord is not required to provide, or to cause Regency Park
Corporation to provide, the health club facility described in 8 above. Likewise, the Tenant
acknowledges that the Landlord is not liable for any common area maintenance for which assessments
are due to third parties (including any owner’s association).

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EXHIBIT F

RULES AND REGULATIONS

     1. The sidewalks and entry passages shall not be obstructed by Tenants, or used by them for
any purpose other than those of ingress and egress. The floors and skylights and windows that
reflect or admit light into any place in said Building shall not be covered or obstructed by
Tenants. The water closets and other water apparatus shall not be used for any other purpose than
those for which they were constructed and no sweepings, rubbish, or other obstructing substances
shall be thrown therein. Any damage resulting to them or to associated systems, from misuse, shall
be borne by Tenants who, or whose clerks, agents, or servants shall cause it.

     2. No Tenant shall do or permit to be done in said Premises, or bring or keep anything
therein, which shall in any way increase the rate of fire insurance on said Building, or on
property kept therein, or obstruct or interfere with the rights of other tenants or in any way
injure or annoy them, or conflict with the laws relating to fires, or with the regulations of the
Fire Department, or any part thereof, or conflict with any of the rules and ordinances of the Board
of Health. Tenants, their clerks and servants shall maintain order in the Building, shall not make
or permit any improper noise in the Building or interfere in any way with other Tenants or those
having business with them. Nothing shall be thrown by Tenants, their clerks or servants out of the
windows or doors, or down the passages or skylights of the Building. No rooms shall be occupied or
used as sleeping or lodging apartments at any time. No part of the Building shall be used or in any
way appropriated for gambling, immoral or other unlawful practices, and no intoxicating liquor or
liquors shall be sold in said Building.

     3. Tenants shall not employ any persons other than the janitors of the Landlord (who will be
provided with pass keys into the offices) for the purpose of cleaning or taking charge of said
Premises. It is understood and agreed that the Landlord shall not be responsible to any Tenant for
any loss of property from rental premises, however occurring, or for any damage done to the
furniture or other effects of any Tenant by the janitor or any of its employees.

     4. No animals, birds, bicycles or other vehicles, or other obstructions, other than those
which are necessitated by an employee or invitee disability, shall be allowed in the offices,
halls, corridors, elevators or elsewhere in the Building.

     5. No painting shall be done, nor shall any alterations be made, to any part of the Building
by putting up or changing any partitions, doors or windows, nor shall there be any nailing, boring
or screwing into the woodwork or plastering, nor shall any connection be made to the electric wires
or gas or electric fixtures, without the consent in writing on each occasion of the Landlord or its
agent, which consent shall be not be reasonably withheld. Tenant must replace and/or repair any
alternations to conditions of the Premises prior to such alternations, including but not limited
to, the hanging of pictures and coat hangers. All glass, locks and trimmings in or upon the doors
and windows of the Building shall be kept whole and, when any part thereof shall be broken, the
same shall be immediately replaced or repaired and put in order under the direction and to the
satisfaction of Landlord, or its agents, and shall be left whole and in good repair. Tenants shall
not injure, overload or deface the Building and Premises, woodwork or walls of the Premises and
Building, nor carry on upon the Premises or in the

- 32 -

 

Building any noisome, noxious, noisy, or offensive business.

     6. Not more than two keys for each Premise will be furnished without charge. No additional
locks or latches shall be put upon any door without the written consent of Landlord. Tenants, at
termination of their lease of the Premises, shall return to Landlord all keys to doors and entry to
Building.

     7. Landlord in all cases retains the power to prescribe the weight and position of iron safes
or other heavy articles. Tenants must make arrangements with the Superintendent of the Building
when the elevator is required for the purpose of the carrying of any kind of freight.

     8. Tenants shall not (without the Landlord’s written consent) put up or operate any steam
engine, boiler, machinery or stove upon the Premises, or carry on any mechanical business thereon,
or do any cooking thereon, or use or allow to be used in the demised Premises oil, burning fluids,
camphene, gasoline or kerosene for heating, warming, or lighting. No article deemed extra hazardous
on account of fire and no explosives shall be brought into said Premises. No offensive gases or
liquids will be permitted.

     9. If Tenants desire blinds or window covering of any kind over the windows, other than what
may be provided by Landlord, they must be of such shape, color, and materials as may be prescribed
by Landlord, and shall be erected with Landlord’s consent and at the expense of said Tenants. No
awnings shall be placed on said Building.

     10. If Tenants require wiring for a business machine, or a bell or buzz system, such wiring
shall be done by the Electrician of the Building only, and no outside wiring men shall be allowed
to do work of this kind unless by the written permission of Landlord or its representatives. If
telegraphic or telephonic service is desired, the wiring for same shall be done as directed by the
Electrician of the Building or by some other employee of Landlord who may be instructed by the
Superintendent of the Building to supervise same, and no boring or cutting for wiring shall be done
unless approved by Landlord or its representatives as stated. The electric current shall not be
used for power or heating unless written permission to do so shall first have been obtained from
Landlord, or its representatives in writing and at an agreed cost to Tenants.

     11. Landlord will post on the directory of its Building one name to be designated by the
Tenant at no charge. All additional names which Tenant shall desire put upon said directory must be
first consented to by Landlord, and if so approved, a charge will be made for each additional
listing as prescribed by Landlord to be paid to Landlord by Tenant.

     12. The elevators in the Premises are not to be used by the Tenants or their agents for moving
furniture into the Premises, incident to the initial occupancy, or moving furniture out, incident
to vacating, except during the hours from 5:30 p.m. to 7:00 a.m. or on Saturdays after the hour of
1:30 p.m. unless approved by the Manager of the Building.

     13. Landlord reserves all vending rights. Request for such service will be made to Landlord.

     14. Landlord shall have the right to make such other and further reasonable rules and
regulations as in its judgment may from time to time be needful for the safety, care, and
cleanliness of the Premises, and for the preservation of good order therein and the same shall be

- 33 -

 

kept and observed by the Tenants, their agents, clerks, servants or employees.

     15. All Public Areas of the Building are “No Smoking” areas. Public Areas are defined as the
corridors, ground floor lobby, elevator lobbies, elevators, men’s and ladies restrooms, stairwells,
and entry vestibule. Anyone wishing to smoke must do so either on their own Premises or outside the
Building. We will provide an ash urn at the delivery entrance of the Building and would ask that
special care be taken by those who wish to smoke in keeping these areas clean.

     16. The Tenant agrees to the foregoing Rules and Regulations which are hereby made a part of
this Lease, and each of them, and agrees that for such persistent infraction of them, or any of
them, as may in the opinion of the Landlord be calculated to annoy or disturb the quiet enjoyment
of any other Tenant, or interfere with the proper operation of the Building, the Landlord may
declare a forfeiture and cancellation of the accompanying Lease and may demand possession of the
demised Premises upon one week’s notice.

     17. The Landlord reserves the right to close the Building after regular working hours and on
legal holidays subject, however, to Tenant’s right of admittance, under such reasonable regulations
as Landlord may prescribe from time to time, which may include by way of example, but not of
limitation, that persons entering or leaving the Building identify themselves by registration or
otherwise and that such persons establish the right to enter or leave the Building.

- 34 -

 

EXHIBIT G

RIGHT OF FIRST OFFER

     The Landlord shall offer first to the Tenant any additional adjacent space as it becomes
available. The Tenant shall have seven (7) business days to reach an agreement in writing with the
Landlord for the acquisition of such adjacent space. If the Landlord and Tenant do not agree within
the time period stated above, the Landlord is free to dispose of the space at its discretion.

- 35 -exv10w25

Exhibit 10.25

ADDENDUM #1

     ADDENDUM #1 made this 18th day of January 2005, between REGENCY PARK CORPORATION, a
North Carolina corporation having its principal place of business in Cary, North Carolina (the
“Landlord”) and CORNERSTONE BIOPHARMA, INC, a Nevada corporation having its principal place of
business in Cary, North Carolina (the “Tenant”).

W I T N E S S E T H:

     WHEREAS, the Landlord and Tenant entered into a written Lease Agreement dated August 11, 2004,
(the “Lease”), whereby the Landlord leased to the Tenant certain premises (the “Premises”) in the
building commonly known as 2000 Regency Parkway, Cary, North Carolina (herein called the
“Building”) and which Premises are more particularly described below in Paragraph 3; and

WHEREAS, the Tenant and Landlord wish to expand the Tenant’s Premises in the Building.

     NOW, THEREFORE, in consideration of the Premises and of the mutual agreements hereinafter set
forth, it is hereby mutually agreed as follows:

	1.	 	The terms and conditions of Addendum #1 shall commence and become effective on February 15,
2005.
	 
	2.	 	ANNUAL RENTAL: Tenant agrees to pay Landlord, at Landlord’s address, 2000 Regency Parkway,
Suite 111, Cary, North Carolina 27511, or at such other place as Landlord may designate in
writing, without demand, deduction, credit or setoff and in lawful money of the United States
of America. Commencing February 15, 2005, rental shall be changed as follows:
	 
	 	 	      Rental of One Hundred Forty-Nine Thousand One Hundred Twelve Dollars ($149,112.00) per
year (“Annual Rent”), payable in equal monthly installments of Twelve Thousand Four Hundred
Twenty-Six and 00/100 Dollars ($12,426.00), in advance, on or before the first day of each
calendar month during the Term; commencing on February 15, 2005, and continuing through
January 31, 2006, provided, however, that if the term commences on a date other than the
first day of a calendar month, rent shall be prorated for the fractional month at the
beginning of the term and paid on the date the term commences; and in that event, rent for
the fractional month at the end of the term shall also be prorated.
	 
	 	 	      Rental of One Hundred Fifty-Three Thousand Thirty-Six Dollars ($153,036.00) per year
(“Annual Rent”), payable in equal monthly installments of Twelve Thousand Seven Hundred
Fifty-Three and 00/100 Dollars ($12,753.00), in advance, on or before the first day of each
calendar month during the term; commencing on February 1, 2006, and continuing through
January 31, 2007, provided, however, that if the term of this Lease commences on a date
other than the first day of a calendar month, rent shall be prorated for the fractional
month at the beginning of the term and paid on the date the term commences; and in that
event, rent for the fractional month at the end of the Term shall also be prorated.

 

	 	 	      Rental of One Hundred Fifty-Six Thousand Nine Hundred Sixty Dollars ($156,960.00) per
year (“Annual Rent”), payable in equal monthly installments of Thirteen Thousand Eighty and
00/100 Dollars ($13,080.00), in advance, on or before the first day of each calendar month
during the term; commencing on February 1, 2007, and continuing through January 31, 2008,
provided, however, that if the term commences on a date other than the first day of a
calendar month, rent shall be prorated for the fractional month at the beginning of the term
and paid on the date the term commences; and in that event, rent for the fractional month at
the end of the term shall also be prorated.
	 
	 	 	      Rental of One Hundred Sixty Thousand Eight Hundred Eighty-Four and 00/100 Dollars
($160,884.00) per year (“Annual Rent”), payable in equal monthly installments of Thirteen
Thousand Four Hundred Seven and 00/100 Dollars ($13,407.00), in advance, on or before the
first day of each calendar month during the term; commencing on February 1, 2008, and
continuing through January 31, 2009, provided, however, that if the term commences on a date
other than the first day of a calendar month, rent shall be prorated for the fractional
month at the beginning of the term and paid on the date the term commences; and in that
event, rent for the fractional month at the end of the term shall also be prorated.
	 
	3.	 	PREMISES: The Premises are designated as Suite 255 consisting of Seven Thousand Eight
Hundred Forty-Eight (7,848) square feet and are shown on Exhibit A-1 attached hereto.
	 
	4.	 	The adjustment for Operating Expenses as shown in Section 2.02.01 of the Lease Agreement
shall reflect the proportionate share as four and ninety-four one-hundredths of one percent
(4.94%) effective February 15, 2005.
	 
	5.	 	The rental adjustment for Real Estate Taxes as shown in Section 2.02.02 of the Lease
Agreement shall reflect the Tenant’s proportionate share as four and ninety-four
one-hundredths of one percent (4.94%) effective February 15, 2005.
	 
	6.	 	FIT-UP: The Landlord, at its cost, shall finish the additional premises in accordance
with the plans provided by IS Design dated January 27, 2005, and agreed to between Landlord
and Tenant. The Landlord shall not be responsible for any Tenant furniture, fixtures or
equipment, including, but not limited to data communication wiring or installation thereof.
	 
	7.	 	SECURITY DEPOSIT: Security Deposit to be Twelve Thousand Four Hundred Twenty-Six and
00/100 Dollars ($12,426.00), payable upon execution of Addendum #1, in accordance with Section
2.03 of the Lease.
	 
	8.	 	All other terms and conditions of the Lease Agreement shall prevail as is, except those
modified by this Addendum #1.

- 2 -

 

     IN WITNESS WHEREOF, this instrument has been duly executed by the parties hereto as of the day
and year first above written.

	 	 	 	 	 
	 	REGENCY PARK CORPORATION

Landlord

 	 
	 	By:  	/s/  Eric M. Salomon
 	 
	 	 	Eric M. Salomon 	 
	 	 	Vice President 	 
	 

	 	 	 	 
	Corporate Seal

ATTEST:

 	 
	/s/ Angela Barton
 	 
	Angela Barton 	 
	Assistant Secretary 	 
	 

	 	 	 	 	 
	 	CORNERSTONE BIOPHARMA, INC

Tenant

 	 
	 	By:  	/s/ Chenyqua Baldwin
 	 
	 	 	Chenyqua Baldwin 	 
	 	 	Chief Financial Officer 	 
	 

	 	 	 	 
	WITNESS

 	 
	/s/ Adrienne  Shields
 	 
	 	 
	 	 
	 

- 3 -

 

Exhibit
A-1

- 4 -

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00148-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00148-of-00352.parquet"}]]