Document:

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                                                                   Exhibit 10.35

                THIRD AMENDMENT TO STANDARD INDUSTRIAL NET LEASE
          (Applied Molecular Evolution, Inc. - 11095 Flintkote Avenue)

                  This THIRD AMENDMENT TO STANDARD INDUSTRIAL NET LEASE is
executed as of March 14, 2003, by and between JBC SORRENTO WEST, LLC, a
California limited liability company ("Landlord"), and APPLIED MOLECULAR
EVOLUTION, INC., a Delaware corporation ("Tenant"), with reference to the
following facts:

                                    RECITALS

                  A. Landlord and Tenant have heretofore entered into that
certain Standard Industrial Net Lease dated November 20, 2000, as amended by
that Certain First Amendment to Standard Industrial Net Lease dated October 1,
2002, and by that Certain Second Amendment to Standard Industrial Net Lease
dated November 14, 2002 (collectively, the "Lease"), for the lease of premises
located at 11095 Flintkote Avenue, San Diego, California 92121 (the "Premises").
The Premises currently comprise Suites A, B, C, D, F and G, and currently
comprise approximately 18,583 square feet.

                  B. Landlord and Tenant desire to amend the Lease on the terms
and conditions set forth herein.

                  C. Capitalized terms not otherwise defined herein shall have
the meanings ascribed to them in the Lease.

                                    AMENDMENT

                  NOW, THEREFORE, in consideration of the foregoing recitals and
the mutual covenants contained herein, and for other valuable consideration, the
receipt and sufficiency of which is hereby acknowledged, the Lease is hereby
amended as follows:

                  1. REVISION AND EXPANSION OF PREMISES.

                        (a) Commencing on the Delivery Date, as defined below,
the Premises shall be expanded to include Suite E of the building located at
11095 Flintkote Avenue, San Diego, California ("Suite E"), which contains
approximately 3,888 square feet.

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                        (b) On and after the Delivery Date, all references in
the Lease and this Amendment to the "Premises" shall include references to Suite
E. As a result of such expansion, on and after the Delivery Date the Premises
will encompass Suites A, B, C, D, E, F and G, and will contain approximately
22,471 total square feet. The Premises, as so expanded, is depicted in the
attached Exhibit "A", and constitute the entire building located at 11095
Flintkote Avenue, San Diego, Ca 92121.

                  2. MINIMUM MONTHLY RENT. The Minimum Monthly Rent shall be the
following amounts for the following periods:

<TABLE>
<CAPTION>
                                                    Suite E           Total (Entire Building)
Period                                              Component         Minimum Monthly Rent
------                                              ---------         --------------------
<S>                                                 <C>              <C>
Through March 31, 2003                                 n/a           As set forth in the Lease
Delivery Date through December 31, 2003              $5,249                    $31,294
January 1, 2004 through December 31, 2004            $5,459                     $42,838
January 1, 2005 through December 31, 2005            $5,677                     $44,550
January 1, 2006 through December 31, 2006            $5,904                     $46,333
January 1, 2007 through December 31, 2007            $6,140                     $48,186
January 1, 2008 through December 31, 2008            $6,386                     $50,114
</TABLE>

                  3. PRO RATA SHARE. As of Delivery Date, Tenant's Pro Rata
Share of Operating Costs (Section 1.6) shall be 13.9%.

                  4. PARKING SPACES. As of Delivery Date, Tenant's allocated
share of the parking spaces in the Center (Section 11.9) shall be sixty-seven
(67) spaces.

                  5. RELOCATION OF CURRENT OCCUPANT; DELIVERY OF SUITE E;
CONTINGENCY.

                        (a) The parties acknowledge that Chantilly Bakery (the
"Current Occupant") currently occupies Suite E. The Current Occupant is in the
process of purchasing and moving to a new location. Landlord has, concurrently
with the execution of this Amendment, entered into a Lease Termination Agreement
with Chantilly Bakery for such vacating of Suite E. Following the vacating of
Suite E and the surrender of the possession thereof by the Current Occupant,
Landlord shall deliver Suite E to Tenant in a broom clean condition with all of
the Current Occupant's trade fixtures removed, but otherwise in "as is, where
is" condition. The date of such delivery shall be the "Delivery Date" as set
forth in this Amendment.

                        (b) As a material inducement for Landlord to execute
this Amendment, Tenant shall pay Landlord Twenty-two Thousand Five Hundred
Dollars ($22,500) upon execution hereof. Landlord shall pay the Current Occupant
a relocation fee to vacate Suite E prior to the Delivery Date, which relocation
fee ($45,000.00) exceeds Twenty-two Thousand Five Hundred Dollars ($22,500).

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                        (c) This Amendment is contingent upon the Current
Occupant vacating and surrendering possession of Suite E. If Landlord is unable
to recover possession of Suite E by June 1, 2003, and deliver the same to
Tenant, then this Agreement shall terminate. Upon any such termination, this
Amendment shall be of no further force or effect and the $22,500.00 contribution
to the relocation fee paid by Tenant pursuant to subsection (a) above shall be
promptly returned to Tenant.

                  6. BROKERAGE COMMISSIONS. Irving Hughes Group has represented
Tenant as real estate broker in connection with this Amendment, and Landlord
shall pay a commission to such broker in respect of Suite E on the terms and
conditions of a separate agreement between such broker and Landlord. Tenant
warrants that it has had no dealings with any other real estate broker or agent
in connection with the negotiation of this transaction, and it knows of no other
real estate broker or agent who is entitled to a commission in connection with
this transaction. Tenant agrees to indemnify, protect, hold harmless and defend
Landlord from and against any obligation or liability to pay any commission or
compensation to any party other than the Irving Hughes Group arising from the
act or agreement of Tenant.

                  7. PRIOR SQUARE FOOTAGE ADJUSTMENT. As a matter of record, the
parties acknowledge that as a result of the field measurement of the original
Premises (Suites A-D) pursuant to Section 1.2 of the Lease dated November 20,
2000, the square footage of Suites A-D was determined to be 15,505 square feet.

                  8. NO OTHER CHANGE. Except as otherwise expressly set forth in
this Amendment, all of the terms and conditions of the Lease remain unchanged
and in full force and effect. IN WITNESS WHEREOF, this Third Amendment to
Standard Industrial Net Lease is executed as of the date first above written.

                               "LANDLORD"

                               JBC SORRENTO WEST,
                               a California limited liability company

                               By: /s/  Robert Peterson
                                   ------------------------------------
                               Print Name:  Robert Peterson
                                          -----------------------------
                                            Authorized Signatory

                               By:  /s/ Harry A. Collins
                                    -----------------------------------
                               Print Name:  Harry A. Collins
                                          -----------------------------
                                            Authorized Signatory

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                               "TENANT"

                               APPLIED MOLECULAR EVOLUTION, INC.,
                               a Delaware corporation

                               By:  /s/ Lawrence E. Bloch
                                   ------------------------------------
                               Name:  Lawrence E. Bloch, M.D., J.D.
                                      ---------------------------------
                               Title:    CFO
                                      ---------------------------------

                                       4<PAGE>

                                                                   Exhibit 10.36

                FOURTH AMENDMENT TO STANDARD INDUSTRIAL NET LEASE
          (Applied Molecular Evolution, Inc. - 11095 Flintkote Avenue)

                  This FOURTH AMENDMENT TO STANDARD INDUSTRIAL NET LEASE is
executed as of August 4, 2003, by and between JBC SORRENTO WEST, LLC, a
California limited liability company ("Landlord"), and APPLIED MOLECULAR
EVOLUTION, INC., a Delaware corporation ("Tenant"), with reference to the
following facts:

                                    RECITALS

                  A. Landlord and Tenant have heretofore entered into that
certain Standard Industrial Net Lease dated November 20, 2000, as amended by
that certain First Amendment to Standard Industrial Net Lease dated October 1,
2002, and by that certain Second Amendment to Standard Industrial Net Lease
dated November 14, 2002, and by that certain Third Amendment to Standard
Industrial Net Lease dated March 14, 2003 (the "Third Amendment") (collectively,
the "Lease"), for the lease of premises located at 11095 Flintkote Avenue, San
Diego, California 92121 (the "Premises").

                  B. Landlord and Tenant desire to amend the Lease on the terms
and conditions set forth herein.

                  C. Capitalized terms not otherwise defined herein shall have
the meanings ascribed to them in the Lease.

                                    AMENDMENT

                  NOW, THEREFORE, in consideration of the foregoing recitals and
the mutual covenants contained herein, and for other valuable consideration, the
receipt and sufficiency of which is hereby acknowledged, the Lease is hereby
amended as follows:

                  1. SUITE E DELIVERY DATE. The parties acknowledge that the
Delivery Date, as defined in Section 5(c) of the Third Amendment, was July 16,
2003. Tenant agrees to waive its right to terminate the Third Amendment under
Section 5(c) thereof, and accordingly Section 5(c) of the Third Amendment is
hereby deleted in its entirety.

                  2. RENT START DATE. To compensate Tenant for the delay in
delivering Suite E, the parties agree that the Suite E component of Minimum
Monthly Rent (Section 2 of the Third Amendment) shall be August 1, 2003.
Accordingly, the chart setting forth the Minimum Monthly Rent in Section 2 of
the Third Amendment should be revised as follows:

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                        (a) The words "Through March 31, 2003" are hereby
deleted and replaced with the words "Through July 31, 2003".

                        (b) The words "Delivery Date through December 31, 2003"
are hereby deleted and replaced with the words "August 1, 2003 through December
31, 2003."

                  3. PRO RATA SHARE. Section 3 of the Third Amendment is hereby
deleted in its entirety and replaced with the following:

                        3. PRO RATA SHARE. As of August 1, 2003, Tenant's Pro
         Rata Share of Operating Costs (Section 1.6) shall be 13.9%.

                  4. FACSIMILE SIGNATURE. The facsimile signature(s) of one or
more parties delivered to the other party or parties shall constitute delivery
of this Amendment.

                  5. COUNTERPARTS. This Amendment may be executed in any number
of identical counterparts, any or all of which may contain the signatures of
less than all of the parties, and all of which shall be construed together as
but a single instrument.

                  6. NO OTHER CHANGE. Except as otherwise expressly set forth in
this Amendment, all of the terms and conditions of the Lease remain unchanged
and in full force and effect.

                  IN WITNESS WHEREOF, this Fourth Amendment to Standard
Industrial Net Lease is executed as of the date first above written.

                             "LANDLORD"

                             JBC SORRENTO WEST,
                             a California limited liability company

                             By: /s/ William Tribolet
                                 --------------------------------------
                             Print Name: William Tribolet
                                         ------------------------------
                                               Authorized Signatory

                             By: /s/ Harry A. Collins
                                ---------------------------------------
                             Print Name:   Harry A. Collins
                                         ------------------------------
                                               Authorized Signatory

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                             "TENANT"

                             APPLIED MOLECULAR EVOLUTION, INC.,
                             a Delaware corporation

                             By:  /s/ Lawrence E. Bloch
                                  -----------------------------------
                             Name:  Lawrence E. Bloch, M.D., J.D.
                                   ----------------------------------
                             Title:  CFO
                                    ---------------------------------

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