Document:

EXHIBIT 10.1
                                                                    ------------

                       THIRD AMENDMENT TO CREDIT AGREEMENT

         THIS THIRD AMENDMENT TO CREDIT AGREEMENT (this "Amendment"), dated as
of November 29, 2005, is by and among CHATTEM, INC., a Tennessee corporation
(the "Borrower"), each of the Borrower's Domestic Subsidiaries (individually a
"Guarantor" and collectively with the Borrower, the "Credit Parties"), the
Persons identified as lenders on the signature pages hereto (the "Lenders") and
BANK OF AMERICA, N.A., as agent for the Lenders (in such capacity, the "Agent").

                               W I T N E S S E T H

         WHEREAS, the Credit Parties, the Lenders, and the Agent have entered
into that certain Credit Agreement dated as of February 26, 2004 (as amended
from time to time, the "Credit Agreement");

         WHEREAS, the Borrower has requested that the Lenders amend the Credit
Agreement as provided herein; and

         WHEREAS, the Lenders have agreed to amend the Credit Agreement on the
terms and conditions hereinafter set forth.

         NOW, THEREFORE, in consideration of the agreements hereinafter set
forth, and for other good and valuable consideration, the receipt and adequacy
of which are hereby acknowledged, the parties hereto agree as follows:

                                     PART I
                                   DEFINITIONS

         Unless otherwise defined herein or the context otherwise requires,
terms used in this Amendment, including its preamble and recitals, have the
meanings provided in the Credit Agreement (as amended hereby).

                                     PART II
                         AMENDMENTS TO CREDIT AGREEMENT

         SUBPART 2.1 The following definitions appearing in Section 1.1 of the
Credit Agreement are hereby amended and restated to read as follows:

                  "Applicable Percentage" means for purposes of calculating the
         applicable interest rate for any day for Loans, the applicable rate for
         any day for the Letter of Credit Fees and the applicable rate for any
         day for the Unused Fee, the appropriate applicable percentages
         corresponding to the Leverage Ratio in effect as of the most recent
         Calculation Date as shown below:
<PAGE>
<TABLE><CAPTION>
=======  ==================  ====================  ================  ================
                                  APPLICABLE
                                PERCENTAGE FOR        APPLICABLE
                               EURODOLLAR LOANS     PERCENTAGE FOR      APPLICABLE
PRICING      LEVERAGE            AND LETTER OF         BASE RATE      PERCENTAGE FOR
 LEVEL         RATIO              CREDIT FEE             LOANS         UNUSED FEES
-------  ------------------  --------------------  ----------------  ----------------
<S>      <C>                 <C>                   <C>               <C>
   I        <1.50 to 1.0            1.00%                0.00%             0.250%
            -
-------  ------------------  --------------------  ----------------  ----------------
   II     >1.50 to 1.0 but          1.25%                0.00%             0.300%
           < 2.50 to 1.0
           -
-------  ------------------  --------------------  ----------------  ----------------
  III     >2.50 to 1.0 but          1.50%                0.00%             0.350%
           < 3.25 to 1.0
           -
-------  ------------------  --------------------  ----------------  ----------------
   IV     >3.25 to 1.0 but          1.75%                0.25%             0.400%
           < 3.75 to 1.0
           -
-------  ------------------  --------------------  ----------------  ----------------
   V       > 3.75 to 1.0            2.00%                0.50%             0.500%
=======  ==================  ====================  ================  ================
</TABLE>

         The Applicable Percentage shall, in each case, be determined and
         adjusted quarterly on the date (each a "Calculation Date") five
         Business Days after the date by which the Borrower is required to
         provide the officer's certificate in accordance with the provisions of
         Section 7.1(c); (i) the Applicable Percentages in effect on November
         29, 2005 shall be based on Pricing Level II (as shown above) and shall
         remain at Pricing Level II until the first Calculation Date following
         the fiscal quarter ending November 30, 2005 and, thereafter, the
         Applicable Percentage shall be determined by the then current Leverage
         Ratio, and (ii) if the Borrower fails to provide the officer's
         certificate required by Section 7.1(c) on or before the most recent
         Calculation Date or fails to deliver a copy of such officer's
         certificate to the Agent as required by Section 7.1(c), the Applicable
         Percentage from such Calculation Date shall be based on Pricing Level V
         until such time that an appropriate officer's certificate is provided
         whereupon the Applicable Percentage shall be determined by the then
         current Leverage Ratio. Each Applicable Percentage shall be effective
         from one Calculation Date until the next Calculation Date. Any
         adjustment in the Applicable Percentage shall be applicable to all
         existing Loans and Letters of Credit as well as any new Loans or
         Letters of Credit made or issued.

                  "Cash Equivalents" means (a) securities issued or directly and
         fully guaranteed or insured by the United States of America or any
         agency or instrumentality thereof (provided that the full faith and
         credit of the United States of America is pledged in support thereof)
         having maturities of not more than two years from the date of
         acquisition, provided that solely with respect to HBA Indemnity
         Company, Ltd ("HBA") such securities of a type described in this
         subpart (a) owned by HBA may have maturities of not more than
         twenty-four months from the date of acquisition, (b) Dollar denominated
         (or with respect to Foreign Subsidiaries, Dollar denominated and non
         Dollar denominated) time deposits, including eurodollar time deposits,
         and certificates of deposit of (i) any Lender, (ii) any domestic (or
         with respect to Foreign Subsidiaries, any domestic or nondomestic)
         commercial bank of recognized standing having capital and surplus in
         excess of $500,000,000 or (iii) any bank whose short-term commercial
         paper rating from S&P is at least A-1 or the equivalent thereof or from
         Moody's is at least P-1 or the equivalent thereof (any such bank being
         an "Approved Bank"), in each case with maturities of not more than two
         years from the date of acquisition, (c) commercial paper and variable
         or fixed rate notes issued by any Approved Bank (or by the parent
         company thereof) or any variable rate notes issued by, or guaranteed
         by, any domestic corporation rated A-1 (or the equivalent thereof) or
         better by S&P or P-1 (or the equivalent thereof) or better by Moody's
         and maturing within 270 days of the date of acquisition, (d) repurchase
         agreements with a

                                        2
<PAGE>
         bank or trust company (including any of the Lenders) or recognized
         securities dealer having capital and surplus in excess of $500,000,000
         for direct obligations issued by or fully guaranteed by the United
         States of America in which the Borrower shall have a perfected first
         priority security interest (subject to no other Liens) and having, on
         the date of purchase thereof, a fair market value of at least 100% of
         the amount of the repurchase obligations, (e) Investments in money
         market investment programs registered under the Investment Company Act
         of 1940, as amended, which are administered by reputable financial
         institutions having capital of at least $500,000,000 and rated AA (or
         the equivalent thereof) or better by S&P or Aa (or the equivalent
         thereof) or better by Moody's, with maturities of not more than two
         years from the date of acquisition and (f) auction rate preferred stock
         issued by any domestic corporation rated AA (or the equivalent thereof)
         or better by S&P or Aa (or the equivalent thereof) or better by
         Moody's, with maturities of not more than two years from the date of
         acquisition.

                  "EBITDA" means, for any period, with respect to the Borrower
         and its Subsidiaries on a consolidated basis, the sum of (a) Net Income
         for such period (excluding the effect of any extraordinary or other
         non-recurring gains and losses outside of the ordinary course of
         business) plus (b) an amount which, in the determination of Net Income
         for such period has been deducted for (i) Interest Expense for such
         period, (ii) total federal, state, foreign or other income taxes for
         such period, (iii) all depreciation and amortization for such period,
         (iv) for the fiscal quarter periods ending on November 30, 2005 and
         February 28, 2006, any non-recurring charges incurred by the Borrower
         during such periods in connection with the redemption or prepayment of
         Subordinated Debt in accordance with Section 8.11 of the Credit
         Agreement (and the termination of related Hedging Agreements),
         including all premiums, fees and legal costs related thereto in an
         aggregate amount not to exceed $2,750,000 in the case of non-cash
         charges and $2,000,000 in the case of cash charges, (v) to the extent
         incurred during the applicable period and subsequent to November 30,
         2003, the amount of any write-down of goodwill required under FASB 142
         in an aggregate amount not to exceed $40,000,000, all as determined in
         accordance with GAAP and (vi) non-cash expenses required under FASB
         123R in connection with unvested stock options less (c) an amount
         which, in the determination of Net Income for such period, has been
         included for the recovery and/or reversal of charges or reserves in
         connection with the Borrower's phenylpropanolamine litigation.

                  "Permitted Acquisition" means the acquisition of all of the
         Capital Stock of another Person, all or substantially all of the assets
         of another Person or a brand or product line of another Person,
         provided that each of the following conditions are satisfied: (a) prior
         to such acquisition, the Borrower shall deliver to the Agent and
         Lenders a Pro Forma Compliance Certificate demonstrating that after
         giving effect to such acquisition on a Pro Forma Basis, the Credit
         Parties and their Subsidiaries would have been in compliance with all
         the financial covenants set forth in Section 7.12, (b) simultaneously
         with any such acquisition, the Borrower shall have taken all action
         required under applicable law, or reasonably requested by the Agent, to
         grant to the Agent, for the benefit of the Lenders, a valid and
         perfected first-priority security interest in all the assets acquired
         pursuant to such acquisition, (c) the acquisition is consummated
         pursuant to a negotiated acquisition agreement and involves the
         purchase of a consumer product or product line similar to those
         manufactured, distributed or sold by the Borrower as of the date
         hereof, or of a business that manufactures, distributes or sells one or
         more consumer products or product lines, similar to those manufactured,
         distributed or sold by the Borrower as of the date hereof, (d) after
         giving effect to the acquisition, the representations and warranties
         set forth in Section 6 hereof shall be true and correct in all material
         respects on and as of the date of such acquisition with the same effect
         as though made on and as of such date, (e) no Default or Event of
         Default exists and is continuing or would result from such acquisition
         and (f) the aggregate consideration (including cash and non-cash
         consideration, assumption of liabilities, Earn Out Obligations and any
         contingency payments

                                        3
<PAGE>
         associated therewith) paid by the Borrower and its Subsidiaries shall
         not exceed $75,000,000 in the aggregate for all such acquisitions
         occurring subsequent to the Closing Date.

                  "Revolving Committed Amount" means ONE HUNDRED MILLION DOLLARS
         ($100,000,000) or such lesser amount as the Revolving Committed Amount
         may be reduced pursuant to Section 2.1(d); provided that the Revolving
         Committed Amount may be increased to up to ONE HUNDRED FIFTY MILLION
         DOLLARS ($150,000,000) pursuant to Section 2.1(e).

                  "Termination Date" means November 15, 2010.

         SUBPART 2.2 Section 2.1(e) of the Credit Agreement is hereby amended
and restated to read as follows:

                  (e)      The Borrower may at any time and from time to time,
         upon prior written notice by the Borrower to the Agent, increase the
         Revolving Committed Amount by up to FIFTY MILLION DOLLARS ($50,000,000)
         with additional Revolving Commitments from any existing Lender or new
         Revolving Commitments from any other Person selected by the Borrower
         and approved by the Agent; provided that:

                           (i) any such increase shall be in a minimum principal
                  amount of $5,000,000 and in integral multiples of $5,000,000
                  in excess thereof;

                           (ii) no Default or Event of Default shall be
                  continuing at the time of any such increase;

                           (iii) no existing Lender shall be under any
                  obligation to increase its Revolving Commitment and any such
                  decision whether to increase its Revolving Commitment shall be
                  in such Lender's sole and absolute discretion; and

                           (iv) any new Lender shall join this Agreement by
                  executing such joinder documents reasonably required by the
                  Agent.

         SUBPART 2.3 Section 7.12(c) of the Credit Agreement is hereby amended
and restated to read as follows:

                  (c)      Senior Secured Leverage Ratio. The Senior Secured
         Leverage Ratio, as of the end of each fiscal quarter, shall be less
         than or equal to 2.50 to 1.0.

         SUBPART 2.4 Section 7.12(d) of the Credit Agreement is hereby amended
and restated to read as follows:

                  (d)      Net Worth. At all times Net Worth shall be no less
         than $88,000,000 increased on a cumulative basis, commencing with the
         fiscal quarter ending November 30, 2005, by an amount equal to, (i) as
         of the last day of each fiscal quarter, 75% of Net Income (calculated
         without giving effect to (x) the amount of any write-down of goodwill
         required under FASB 142 occurring or incurred subsequent to November
         30, 2005 in an aggregate amount not to exceed $20,000,000, and (y) for
         the fiscal quarter periods ending on November 30, 2005 and February 28,
         2006, any non-recurring charges incurred by the Borrower during such
         periods in connection with the redemption or prepayment of Indebtedness
         evidenced by the Floating Rate Indenture (and the termination of
         related Hedging Agreements), including all premiums, fees and legal
         costs related thereto in an aggregate amount not to exceed $2,750,000
         in the case of non-cash charges and $2,000,000 in the case of cash
         charges) for the fiscal quarter then ended (without deduction for

                                        4
<PAGE>
         losses)) plus (ii) 100% of the gross cash proceeds (net of transaction
         costs and taxes) from any Equity Issuance subsequent to November 30,
         2005. For purposes of determining compliance with the Net Worth
         covenant set forth above, the base number of $88,000,000 set forth
         above shall be reduced by (i) the amount of any write-down of goodwill
         required under FASB 142 occurring or incurred subsequent to November
         30, 2005 in an aggregate amount not to exceed $20,000,000 (ii)
         repurchases of the Borrower's Capital Stock occurring subsequent to
         November 30, 2005 permitted by Section 8.7 in an aggregate amount not
         to exceed $100,000,000 and (iii) for the fiscal quarter periods ending
         on November 30, 2005 and February 28, 2006, any non-recurring charges
         incurred by the Borrower during such periods in connection with the
         redemption or prepayment of Indebtedness evidenced by the Floating Rate
         Indenture in accordance with Section 8.11 of the Credit Agreement (and
         the termination of related Hedging Agreements), including all premiums,
         fees and legal costs related thereto in an aggregate amount not to
         exceed $2,750,000 in the case of non-cash charges and $2,000,000 in the
         case of cash charges.

         SUBPART 2.5 Section 7.12(e) of the Credit Agreement is hereby amended
and restated to read as follows:

                  (e)      Brand Value. As of the end of each fiscal quarter of
         the Borrower, with respect to the Borrower and its Subsidiaries on a
         consolidated basis, the book value of all brands or product lines of
         the Borrower and its Subsidiaries on a consolidated basis on such date
         shall be greater than or equal to $190,000,000.

         SUBPART 2.6 Section 8.5 of the Credit Agreement is hereby amended and
restated to read as follows:

         8.5      SALE OR LEASE OF ASSETS.

                  No Credit Party will, nor will it permit any of its
         Subsidiaries to, convey, sell, lease, transfer or otherwise dispose of,
         in one transaction or a series of transactions, all or any part of its
         business or assets whether now owned or hereafter acquired, including,
         without limitation, inventory, receivables, real property, leasehold
         interests, equipment and securities other than (a) any inventory or
         other assets sold, leased or disposed of (or simultaneously replaced
         with like goods) in the ordinary course of business, (b) obsolete, idle
         or worn-out assets no longer used or useful in its business, (c) the
         sale, lease or transfer or other disposal by a Credit Party other than
         the Borrower of any or all of its assets to the Borrower or to any
         other Credit Party, (d) the sale, transfer or other disposition of
         "margin stock" within the meaning of Regulation U, (e) the non-recourse
         sale of trade accounts receivable to a Person that is not an Affiliate
         of the Borrower provided that (i) at the time of the sale (and after
         giving effect thereto) no Default or Event of Default exists, (ii) as a
         result of such sale, no Material Adverse Effect would occur or be
         reasonably expected to occur, and (iii) the amount of such receivables
         subject to such sales do not exceed, in the aggregate, $7,000,000 at
         any time outstanding, (f) other sales of equipment provided that (i)
         the sale is for fair market value, (ii) the sale is for cash
         consideration, (iii) at the time of the sale (and after giving effect
         thereto) no Default or Event of Default exists, (iv) as a result of
         such sale, no Material Adverse Effect would occur or be reasonably
         expected to occur and (v) such sales do not exceed, in the aggregate,
         $250,000 during any fiscal year, (g) sales of product lines (or the
         right to produce a consumer product or products) provided that (i) the
         dispositions permitted under this subparagraph (g) shall not exceed
         $10,000,000 (excluding the sale of the PHISODERM(R) product line)
         during any fiscal year and, (ii) the dispositions permitted under this
         subparagraph (g) during any fiscal year shall be limited to product
         lines (or the right to produce a consumer product or products)
         (excluding the sale of the PHISODERM(R) product line) having aggregate
         sales for the twelve-month period ending on the fiscal quarter ending
         immediately preceding the sale in an aggregate amount not exceeding ten
         percent (10%) of EBITDA for such twelve month period and

                                        5
<PAGE>
         (iii) the Credit Parties shall have delivered to the Agent a Pro Forma
         Compliance Certificate demonstrating that after giving effect to any
         such disposition on a Pro Forma Basis, the Credit Parties and their
         Subsidiaries would have been in compliance with all the financial
         covenants set forth in Section 7.12, (h) the transfer by the Borrower
         of the Capital Stock of Chattem (U.K.) Limited to Chattem Global
         Consumer Products Limited and (i) the sale, lease or transfer or other
         disposal by a Foreign Subsidiary of the Borrower of any or all of its
         assets to any other Foreign Subsidiary of the Borrower.

         SUBPART 2.7 Section 8.7 of the Credit Agreement is hereby amended and
restated to read as follows:

         8.7      RESTRICTED PAYMENTS.

                  No Credit Party will, nor will it permit any of its
         Subsidiaries to, directly or indirectly, (a) declare or pay any
         dividends (whether cash or otherwise) or make any other distribution
         upon any shares of its Capital Stock of any class or (b) purchase,
         redeem or otherwise acquire or retire or make any provisions for
         redemption, acquisition or retirement of any shares of its Capital
         Stock of any class or any warrants or options to purchase any such
         shares (any such declaration, payment, distribution, purchase,
         redemption or other acquisition, a "Restricted Payment"); provided,
         however, (i) the Subsidiaries of the Borrower may pay dividends to the
         Borrower and (ii) the Borrower may purchase, redeem, acquire or retire
         shares of its Capital Stock of any class or any warrants or options to
         purchase any such shares of its Capital Stock occurring subsequent to
         November 30, 2005 in an amount not to exceed $100,000,000 in the
         aggregate during the term of this Credit Agreement so long as (A) after
         giving effect thereto no Default or Event of Default exists and (B) the
         Borrower shall have provided the Agent a Pro Forma Compliance
         Certificate demonstrating that after giving effect to any such
         transaction on a Pro Forma Basis, the Credit Parties and their
         Subsidiaries would have been in compliance with all the financial
         covenants set forth in Section 7.12.

         SUBPART 2.8 Section 8.11 of the Credit Agreement is hereby amended and
restated to read as follows:

         8.11     SUBORDINATED DEBT.

                  Notwithstanding Section 8.10, no Credit Party will (i) make or
         offer to make any principal payments with respect to the Subordinated
         Debt, (ii) redeem or offer to redeem any of the Subordinated Debt or
         (iii) deposit any funds intended to discharge or defease any or all of
         the Subordinated Debt; provided, however, the Borrower may redeem or
         repurchase the Subordinated Debt in an aggregate amount not to exceed
         $20,000,000 (such amount to include any accrued interest, premiums or
         penalties associated therewith) during any fiscal year provided the
         Credit Parties shall have delivered to the Agent a Pro Forma Compliance
         Certificate demonstrating that after giving effect to such repurchase
         or redemption on a Pro Forma Basis, the Credit Parties and their
         Subsidiaries would have been in compliance with all the financial
         covenants set forth in Section 7.12. The Subordinated Debt or the
         Subordinated Indenture may not be amended or modified in any material
         manner without the prior written consent of the Required Lenders, it
         being specifically understood and agreed that no amendment to Article
         Four or Article Twelve of the Subordinated Indenture shall be made
         without the prior written consent of the Required Lenders.

         SUBPART 2.9 Section 8.15 of the Credit Agreement is hereby amended and
restated to read as follows:

                                        6
<PAGE>
         8.15     CAPITAL EXPENDITURES.

                  The Credit Parties and their Subsidiaries will not make
         Capital Expenditures, in any fiscal year, that would exceed $7,500,000
         in the aggregate; provided, however, in addition to the maximum annual
         Capital Expenditures permitted by the preceding clause, the Credit
         Parties shall also be permitted to make a one time Capital Expenditure
         not to exceed $8,000,000 for the construction and/or acquisition of a
         warehouse located in Chattanooga, Tennessee.

         SUBPART 2.10 Schedule 1.1(a) of the Credit Agreement is hereby amended
and replaced with Schedule 1.1(a) attached hereto.

                                    PART III
                           CONDITIONS TO EFFECTIVENESS

         SUBPART 3.1 Effective Date. This Amendment shall be and become
effective as of November 29, 2005, subject to the satisfaction of the following
conditions:

                  (a) Execution of Counterparts of Amendment. The Agent shall
         have received counterparts of this Amendment, which collectively shall
         have been duly executed on behalf of the Borrower, the Guarantors, the
         Lenders and the Agent.

                  (b) Authority Documents and Opinions. The Agent shall have
         received (i) copies of resolutions of the board of directors (or
         comparable governing authority) of each of the Credit Parties approving
         and adopting this Amendment and authorizing execution and delivery
         thereof, certified by a secretary or assistant secretary of such Credit
         Party to be true and correct and in force and effect as of the date
         hereof and (ii) a written opinion of legal counsel for the Credit
         Parties, dated as of the date hereof, in form and substance reasonably
         satisfactory to the Agent.

                  (c) Amendment Fees. The Borrower shall have paid to the Agent,
         (i) for the account of each Lender executing this Amendment, a fee
         equal to 0.125% of such Lender's Commitments (calculated prior to
         giving effect to this Amendment) and (ii) for the account of each
         Lender increasing its Commitment, a fee equal to 0.20% of such increase
         to such Lender's Commitment.

                  (d) Tennessee Recording Taxes. The Borrower shall have paid
         applicable Tennessee recording taxes resulting from the increase in the
         Revolving Commitments.

                  (e) Agent's Fees and Expenses. The Borrower shall have paid to
         the Agent, all reasonable costs and expenses of the Agent in connection
         with the preparation, execution and delivery of this Amendment,
         including without limitation the reasonable fees and expenses of the
         Agent's legal counsel.

                                     PART IV
                                  MISCELLANEOUS

         SUBPART 4.1 Representations and Warranties. Each Credit Party hereby
represents and warrants to the Agent and the Lenders that (a) no Default or
Event of Default exists under the Credit Agreement or any of the other Credit
Documents on and as of the date hereof, (b) each Credit Party has the requisite
corporate power and authority to execute, deliver and perform this Amendment and
(c) the representations and warranties set forth in Section 6 of the Credit
Agreement are true and correct in all material respects as of the date hereof
(except for those which expressly relate to an earlier date). Each

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<PAGE>
Credit Party acknowledges and confirms that the Borrower's obligations to repay
the outstanding principal amount of the Loans are unconditional and not subject
to any offsets, defenses or counterclaims.

         SUBPART 4.2 Acknowledgment. Each Guarantor hereby acknowledges and
consents to all of the terms and conditions of this Amendment and agrees that
this Amendment does not operate to reduce or discharge the Guarantors'
obligations under the Credit Agreement or the other Credit Documents.

         SUBPART 4.3 Cross-References. References in this Amendment to any Part
or Subpart are, unless otherwise specified, to such Part or Subpart of this
Amendment.

         SUBPART 4.4 Instrument Pursuant to Credit Agreement. This Amendment is
a Credit Document executed pursuant to the Credit Agreement and shall (unless
otherwise expressly indicated therein) be construed, administered and applied in
accordance with the terms and provisions of the Credit Agreement.

         SUBPART 4.5 References in Other Credit Documents. At such time as this
Amendment shall become effective pursuant to the terms of Subpart 3.1, all
references in the Credit Documents to the "Credit Agreement" shall be deemed to
refer to the Credit Agreement as amended by this Amendment.

         SUBPART 4.6 Counterparts/Telecopy. This Amendment may be executed by
the parties hereto in several counterparts, each of which shall be deemed to be
an original and all of which shall constitute together but one and the same
agreement. Delivery of executed counterparts of the Amendment by telecopy shall
be effective as an original and shall constitute a representation that an
original shall be delivered.

         SUBPART 4.7 Governing Law. THIS AMENDMENT SHALL BE DEEMED TO BE A
CONTRACT MADE UNDER AND GOVERNED BY THE INTERNAL LAWS OF THE STATE OF TENNESSEE.

         SUBPART 4.8 Successors and Assigns. This Amendment shall be binding
upon and inure to the benefit of the parties hereto and their respective
successors and assigns.

         SUBPART 4.9 General. Except as amended hereby, the Credit Agreement and
all other Credit Documents shall continue in full force and effect.

            [The remainder of this page is intentionally left blank.]

                                        8
<PAGE>
         IN WITNESS WHEREOF the Borrower, the Guarantors and the Lenders have
caused this Amendment to be duly executed on the date first above written.

BORROWER:                        CHATTEM, INC.,
--------                         a Tennessee corporation

                                 By:
                                    --------------------------------------------
                                 Name:
                                      ------------------------------------------
                                 Title:
                                       -----------------------------------------

GUARANTORS:                      SIGNAL INVESTMENT & MANAGEMENT CO.,
----------                       a Delaware corporation

                                 By:
                                    --------------------------------------------
                                 Name:
                                      ------------------------------------------
                                 Title:
                                       -----------------------------------------

                                 SUNDEX, LLC,
                                 a Tennessee limited liability company

                                 By:
                                    --------------------------------------------
                                 Name:
                                      ------------------------------------------
                                 Title:
                                       -----------------------------------------

                                 CHATTEM (CANADA) HOLDINGS, INC.,
                                 a Delaware corporation

                                 By:
                                    --------------------------------------------
                                 Name:
                                      ------------------------------------------
                                 Title:
                                       -----------------------------------------
<PAGE>
AGENT:                           BANK OF AMERICA, N.A.,
-----                            in its capacity as Agent

                                 By:
                                    --------------------------------------------
                                 Name:
                                      ------------------------------------------
                                 Title:
                                       -----------------------------------------

LENDERS:                         BANK OF AMERICA, N.A.,
-------                          in its capacity as a Lender

                                 By:
                                    --------------------------------------------
                                 Name:
                                      ------------------------------------------
                                 Title:
                                       -----------------------------------------

                                 SUNTRUST BANK

                                 By:
                                    --------------------------------------------
                                 Name:
                                      ------------------------------------------
                                 Title:
                                       -----------------------------------------

                                 BRANCH BANKING AND TRUST

                                 By:
                                    --------------------------------------------
                                 Name:
                                      ------------------------------------------
                                 Title:
                                       -----------------------------------------

                                 NATIONAL CITY BANK

                                 By:
                                    --------------------------------------------
                                 Name:
                                      ------------------------------------------
                                 Title:
                                       -----------------------------------------EXHIBIT 10.2
                                                                    ------------
                                     FORM OF
                                     -------
                       FIRST AMENDMENT TO GRANT AGREEMENT
                       ----------------------------------
                                       OF
                                       --
                                  CHATTEM, INC.
                                  -------------

          (APPLIES ONLY TO CERTAIN EMPLOYEES AND EXECUTIVE OFFICERS(1))

         THIS FIRST AMENDMENT TO GRANT AGREEMENT (this "Amendment") is made and
entered to be effective as of the 30th day of November, 2005 (the "Effective
Date"), by and between Chattem, Inc., a Tennessee corporation ("Chattem"), and
________________________ ("Optionee"), and amends the Grant Agreement (as
defined below). Capitalized terms used herein but not defined shall have the
meaning ascribed to such terms in the Chattem, Inc. Stock Incentive Plan - 2005
(the "Plan").

         WHEREAS, pursuant to the Plan, as adopted by the Board of Directors on
January 25, 2005 and approved by Chattem's shareholders at their annual meeting
on April 13, 2005, the Committee has granted certain Non-Qualified Stock Options
(the "Granted Options") to Optionee as set forth on Schedule A hereto, in
accordance with the provisions of the Grant Agreement dated ________________,
2005, the Terms and Conditions of Stock Option Grant attached thereto
(collectively, the "Grant Agreement") and the Plan;

         WHEREAS, the Grant Agreement outlines a four-year vesting schedule (the
"Vesting Schedule"), pursuant to which the Granted Options will become vested in
Optionee; and

         WHEREAS, the Committee has approved certain modifications to the Grant
Agreement as reflected in this Amendment, and Chattem and Optionee desire to
enter into this Amendment, upon the terms and conditions set forth herein.

         NOW, THEREFORE, in consideration of the premises and mutual covenants
and obligations set forth herein, and for other good and valuable consideration,
the receipt and legal sufficiency of which is hereby acknowledged, the parties
hereto agree to amend the Grant Agreement as follows:

         1.    Notwithstanding the Vesting Schedule set forth in the Grant
Agreement, the vesting of any and all unvested Granted Options is hereby
accelerated, and such Granted Options shall become fully vested as of the
Effective Date. Any such unvested Granted Options which become vested in
Optionee as a result of such acceleration are hereby referred to as the
"Accelerated Options."

         2.    Optionee hereby acknowledges, understands and agrees that
Optionee shall be prohibited from transferring the shares of common stock of
Chattem which Optionee may
_______________
(1) This Amendment applies only to the following Optionees: Zan Guerry, Robert
E. Bosworth, Andrea M. Crouch, Ron Galante, Richard W. Kornhauser, Richard D.
Moss, B. Derrill Pitts, Donald K. Riker, Charles M. Stafford, Theodore K.
Whifield, Jr., Blair Ramey, Dean Patten and Joe Czerwinski.
<PAGE>

acquire upon the exercise of any portion of the Accelerated Options prior to the
earlier of the date such options would have become vested as set forth in the
Vesting Schedule or as otherwise specified in the Plan.

         3.    Except as specifically amended hereby, the Grant Agreement shall
remain in full force and effect as originally executed.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                        2
<PAGE>

         IN WITNESS WHEREOF, this First Amendment to Grant Agreement of Chattem,
Inc. is hereby executed to be effective as of the date first above written.

                                             CHATTEM:

                                             CHATTEM, INC.

                                             _________________________________

                                             By: _____________________________

                                             OPTIONEE:

                                             _________________________________

                                             Printed Name:____________________

                                        3

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