Document:

NOTE
      (“the Note”)

    

    Power3
      Medical Products, Inc., a New York corporation (the “Company”) for value
      received hereby promises to pay Steven
      B. Rash
      (“Payee”) Upon Demand, (“Maturity Date”); the principal amount of
      five thousand eight hundred dollars ($5,800.00) (“Principal”).

    

    Should
      the Principal not be repaid Upon Demand, interest of 6 % per year on any unpaid
      Principal amount will be earned by the Payee until such time as all of the
      Principal amount is repaid. This Note may be repaid at any time prior to Upon
      Demand without interest or penalty. 

    

    In
      no
      event shall interest contracted for, charged or received hereunder, plus any
      other charges in connection herewith which constitute interest, exceed the
      maximum interest permitted by applicable law. The amounts of such interest
      or
      other charges previously paid to the holder of the Note, if any, in excess
      of
      the amounts permitted by applicable law shall be applied by the holder of the
      Note to reduce the principal of the indebtedness evidenced by the Note, or,
      at
      the option of the holder of the Note, be refunded. To the extent permitted
      by
      applicable law, determination of the legal maximum amount of interest shall
      at
      all times be made by amortizing, prorating, allocating and spreading in equal
      parts during the period of the full stated term of the loan and indebtedness,
      all interest at any time contracted for, charged or received from the Maker
      hereof in connection with the loan and indebtedness evidenced hereby, so that
      the actual rate of interest on account of such indebtedness is uniform
      throughout the term hereof.

    

    Notices,
      payments, requests, and other communications to the respective parties hereunder
      shall be in writing, and shall be deemed received when delivered personally,
      by
      facsimile, or first class certified mail, return receipt requested and postage
      prepaid, as follows:

    

    If
      to the
      lender:

    

    Steven
      B.
      Rash

    3400
      Research Forest Drive 

    Woodlands,
      Texas 77381

    

    If
      to the
      Company:

    

    Power3
      Medical Products, Inc.

    3400
      Research Forest Drive 

    Woodlands,
      Texas 77381

    

    This
      Note
      is governed by and is to be construed in accordance with the law of the State
      of
      Texas.

     

    
      	 Payee	 	Power3
              Medical Products, Inc.	 	Date
	
               

              /s/ Steven B. Rash

              
                

              
Steven B. Rash	 	/s/ John P. Burton 

              
By:
              John P. Burton	 	October
              27, 2006
	 	 	
              Its:
                CFONOTE
      (“the Note”)

    

    Power3
      Medical Products, Inc., a New York corporation (the “Company”) for value
      received hereby promises to pay Steven
      B. Rash
      (“Payee”) on or before March 30, 2006, (“Maturity Date”); the principal amount
      of
      three hundred fifteen thousand ten dollars ($315,010.00) (“Principal”).

    

    Should
      the Principal not be repaid as of March 30, 2006 interest of 6 % per year on
      any
      unpaid Principal amount will be earned by the Payee until such time as all
      of
      the Principal amount is repaid. This Note may be repaid at any time prior to
      March 30, 2006 without interest or penalty. 

    

    In
      no
      event shall interest contracted for, charged or received hereunder, plus any
      other charges in connection herewith which constitute interest, exceed the
      maximum interest permitted by applicable law. The amounts of such interest
      or
      other charges previously paid to the holder of the Note, if any, in excess
      of
      the amounts permitted by applicable law shall be applied by the holder of the
      Note to reduce the principal of the indebtedness evidenced by the Note, or,
      at
      the option of the holder of the Note, be refunded. To the extent permitted
      by
      applicable law, determination of the legal maximum amount of interest shall
      at
      all times be made by amortizing, prorating, allocating and spreading in equal
      parts during the period of the full stated term of the loan and indebtedness,
      all interest at any time contracted for, charged or received from the Maker
      hereof in connection with the loan and indebtedness evidenced hereby, so that
      the actual rate of interest on account of such indebtedness is uniform
      throughout the term hereof.

    

    Notices,
      payments, requests, and other communications to the respective parties hereunder
      shall be in writing, and shall be deemed received when delivered personally,
      by
      facsimile, or first class certified mail, return receipt requested and postage
      prepaid, as follows:

    

    If
      to the
      lender:

    

    Steven
      B.
      Rash

    3400
      Research Forest Parkway 

    Woodlands,
      Texas 77381

    

    If
      to the
      Company:

    

    Power3
      Medical Products, Inc.

    3400
      Research Forest Parkway 

    Woodlands,
      Texas 77381

    

    This
      Note
      is governed by and is to be construed in accordance with the law of the State
      of
      Texas.

     

    
      	Payee	
            	Power3 Medical Products, Inc.	 	   Date
	
               

              /s/ Steven B. Rash  

              
                

              
Steven
              B. Rash	 	
              /s/ John P. Burton

              
                

              
By: John P. Burton	 	 September 30, 2006
	 	 	
              Its:
                CFONOTE
      (“the Note”)

    

    Power3
      Medical Products, Inc., a New York corporation (the “Company”) for value
      received hereby promises to pay Steven
      B. Rash
      (“Payee”) on or before July 19, 2006, (“Maturity Date”); the principal amount
      of
      forty thousand five hundred fifteen dollars ($40,515.00) (“Principal”).

    

    Should
      the Principal not be repaid as of July 19, 2006 interest of 6 % per year on
      any
      unpaid Principal amount will be earned by the Payee until such time as all
      of
      the Principal amount is repaid. This Note may be repaid at any time prior to
      July 19, 2006 without interest or penalty. 

    

    In
      no
      event shall interest contracted for, charged or received hereunder, plus any
      other charges in connection herewith which constitute interest, exceed the
      maximum interest permitted by applicable law. The amounts of such interest
      or
      other charges previously paid to the holder of the Note, if any, in excess
      of
      the amounts permitted by applicable law shall be applied by the holder of the
      Note to reduce the principal of the indebtedness evidenced by the Note, or,
      at
      the option of the holder of the Note, be refunded. To the extent permitted
      by
      applicable law, determination of the legal maximum amount of interest shall
      at
      all times be made by amortizing, prorating, allocating and spreading in equal
      parts during the period of the full stated term of the loan and indebtedness,
      all interest at any time contracted for, charged or received from the Maker
      hereof in connection with the loan and indebtedness evidenced hereby, so that
      the actual rate of interest on account of such indebtedness is uniform
      throughout the term hereof.

    

    Notices,
      payments, requests, and other communications to the respective parties hereunder
      shall be in writing, and shall be deemed received when delivered personally,
      by
      facsimile, or first class certified mail, return receipt requested and postage
      prepaid, as follows:

    

    If
      to the
      lender:

    

    Steven
      B.
      Rash

    3400
      Research Forest Parkway 

    Woodlands,
      Texas 77381

    

    If
      to the
      Company:

    

    Power3
      Medical Products, Inc.

    3400
      Research Forest Parkway 

    Woodlands,
      Texas 77381

    

    This
      Note
      is governed by and is to be construed in accordance with the law of the State
      of
      Texas.

     

    
      	Payee	 	Power3
              Medical Products, Inc.	 	Date
	
               

              /s/ Steven B. Rash 

                

              
Steven B. Rash	 	/s/ John P. Burton 

              
By:
              John P. Burton	 	January
              20, 2006
	  	 	
              Its:
                CFONOTE
      (“the Note”)

    

    Power3
      Medical Products, Inc., a New York corporation (the “Company”) for value
      received hereby promises to pay Ira
      L. Goldknopf
      (“Payee”) on or before March 30, 2006, (“Maturity Date”); the principal amount
      of
      eighteen thousand one hundred thirty-five dollars ($18,135.00)
(“Principal”).

    

    Should
      the Principal not be repaid as of March 30, 2006 interest of 6 % per year on
      any
      unpaid Principal amount will be earned by the Payee until such time as all
      of
      the Principal amount is repaid. This Note may be repaid at any time prior to
      March 30, 2006 without interest or penalty. 

    

    In
      no
      event shall interest contracted for, charged or received hereunder, plus any
      other charges in connection herewith which constitute interest, exceed the
      maximum interest permitted by applicable law. The amounts of such interest
      or
      other charges previously paid to the holder of the Note, if any, in excess
      of
      the amounts permitted by applicable law shall be applied by the holder of the
      Note to reduce the principal of the indebtedness evidenced by the Note, or,
      at
      the option of the holder of the Note, be refunded. To the extent permitted
      by
      applicable law, determination of the legal maximum amount of interest shall
      at
      all times be made by amortizing, prorating, allocating and spreading in equal
      parts during the period of the full stated term of the loan and indebtedness,
      all interest at any time contracted for, charged or received from the Maker
      hereof in connection with the loan and indebtedness evidenced hereby, so that
      the actual rate of interest on account of such indebtedness is uniform
      throughout the term hereof.

    

    Notices,
      payments, requests, and other communications to the respective parties hereunder
      shall be in writing, and shall be deemed received when delivered personally,
      by
      facsimile, or first class certified mail, return receipt requested and postage
      prepaid, as follows:

    

    If
      to the
      lender:

    

    Ira
      L.
      Goldknopf

    3400
      Research Forest Parkway 

    Woodlands,
      Texas 77381

    

    If
      to the
      Company:

    

    Power3
      Medical Products, Inc.

    3400
      Research Forest Parkway 

    Woodlands,
      Texas 77381

    

    This
      Note
      is governed by and is to be construed in accordance with the law of the State
      of
      Texas.

     

    
      	Payee	 	Power3
              Medical Products, Inc.	 	Date
	
               

              /s/ Ira L. Goldknopf 

                

              
Ira L. Goldknopf	 	
              /s/ John P. Burton

              
                

              
By: John P. Burton	 	September 30, 2006
	 	 	
              Its:
                CFO

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