Document:

Form of Floating Rate Senior Notes

 Exhibit 4.3 

[FORM OF FLOATING RATE SENIOR NOTES] 

INTEREST PAYMENTS ON THIS SECURITY GENERALLY WILL BE SUBJECT TO JAPANESE WITHHOLDING TAX UNLESS IT IS ESTABLISHED THAT THIS SECURITY IS HELD
BY OR FOR THE ACCOUNT OF A BENEFICIAL OWNER THAT IS (I) FOR JAPANESE TAX PURPOSES, NEITHER (X) AN INDIVIDUAL RESIDENT OF JAPAN OR A JAPANESE CORPORATION, NOR (Y) AN INDIVIDUAL NON-RESIDENT OF JAPAN OR A NON-JAPANESE CORPORATION THAT
IN EITHER CASE IS A SPECIALLY-RELATED PERSON OF THE COMPANY, (II) A JAPANESE DESIGNATED FINANCIAL INSTITUTION DESCRIBED IN ARTICLE 6, PARAGRAPH 9 OF THE SPECIAL TAXATION MEASURES ACT WHICH COMPLIES WITH THE REQUIREMENT FOR TAX EXEMPTION UNDER THAT
PARAGRAPH OR (III) A PUBLIC CORPORATION, A FINANCIAL INSTITUTION OR A FINANCIAL INSTRUMENTS BUSINESS OPERATOR DESCRIBED IN ARTICLE 3-3, PARAGRAPH 6 OF THE SPECIAL TAXATION MEASURES ACT WHICH COMPLIES WITH THE REQUIREMENT FOR TAX EXEMPTION UNDER THAT
PARAGRAPH. 
 INTEREST PAYMENTS ON THIS SECURITY TO AN INDIVIDUAL RESIDENT OF JAPAN, TO A JAPANESE CORPORATION NOT DESCRIBED IN THE
PRECEDING PARAGRAPH, OR TO AN INDIVIDUAL NON-RESIDENT OF JAPAN OR A NON-JAPANESE CORPORATION THAT IN EITHER CASE IS A SPECIALLY-RELATED PERSON OF THE COMPANY WILL BE SUBJECT TO DEDUCTION IN RESPECT OF JAPANESE INCOME TAX AT A CURRENT RATE OF 15.315%
OF THE AMOUNT OF SUCH INTEREST. 

  
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		  		  	CUSIP Number:	 	[    ]	  	
		  		  	ISIN Code:	 	[    ]	  	
		  		  	Common Code:	 	[    ]	  	
					
	No. [    ]	  	$[    ]	  		 		  	

 MITSUBISHI UFJ FINANCIAL GROUP, INC. 

GLOBAL SECURITY 
 FLOATING RATE
SENIOR NOTES DUE [    ] 
 Mitsubishi UFJ Financial Group, Inc., a corporation (kabushiki kaisha) established
under the laws of Japan (the “Company”), for value received, hereby promises to pay to [Cede & Co.], or registered assigns, on
[                    ], the principal sum set forth above or such other amount as is shown on the Register on
[                    ] in United States Dollars at the Company’s office or agency for said purpose in the Borough of Manhattan, The City of New
York (or at such other office or agency as the Company shall have appointed for such purpose), in such coin or currency of the United States of America as at the time of payment shall be legal tender for the payment of public and private debts, and
to pay interest, at a per annum rate equal to the London interbank offered rate for three-month deposits in U.S. dollars plus [    ]% computed on the basis of the actual number of days and a 360-day year, payable quarterly in
arrears on [                    ],
[                    ], [                    ]
and [                    ] of each year, subject to adjustments as described below, on said principal sum in like coin or currency at said office or
agency from [                        ],
[                    ], [                    ] or
[                    ], as the case may be, subject to adjustments as described below, next preceding the date of this Security to which interest on
the Securities has been paid or duly provided for, unless the date hereof is a date to which interest on the Securities has been paid or duly provided for, in which case from the date of this Security, or unless no interest has been paid or duly
provided for on the Securities, in which case from [    ], until payment of said principal sum has been made or duly provided for. 

If [                    ],
[                    ], [                    ] or
[                    ], as the case may be (each, an “Interest Payment Date”), other than the maturity date, falls on a day that is
not both a Business Day and London Banking Day, the Interest Payment Date shall be adjusted to be the next succeeding day that is both a Business Day and London Banking Day, except that if such day is in the next succeeding calendar month, the
Interest Payment Date shall be adjusted to be the immediately preceding day that is both a Business Day and London Banking Day. In the event [                ] is not
both a Business Day and London Banking Day, the payment of interest and principal in respect of the Securities shall be made on the next succeeding day that is both a Business Day and London Banking Day, and no interest on such payment shall accrue
for the period from and after [                    ]. As used herein, “Business Day” means a day which is not a day on which banking
institutions in New York City and Tokyo are authorized by law or regulation to close, and “London Banking Day” means a day on which commercial banks are open for business, including dealings in foreign exchange and foreign currency
deposits, in London. 
 As used herein, “Interest Period” means each period beginning on (and including) an Interest
Payment Date (after any adjustments to make such date a Business Day and London Banking Day) and ending on (but excluding) the next Interest Payment Date (after any adjustments to make such date a Business Day and London Banking Day). For purposes
of the first interest payment on [                    ], the Interest Period shall begin on (and include)
[                    ]. For purposes of the interest payment on the maturity date, the Interest Period shall end on (and exclude)
[                    ]. 

  
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 Notwithstanding the foregoing, if the date hereof is after 5 p.m., New York City time, on the day
five Business Days immediately preceding the following Interest Payment Date, this Security shall bear interest from such Interest Payment Date; provided, however, that if the Company shall default in the payment of interest due on such
Interest Payment Date (in such case, as such date is extended by the period of grace set forth in the Indenture), then this Security shall bear interest from the next preceding Interest Payment Date to which interest has been paid or duly provided
for, or, if no interest has been paid or duly provided for on this Security, from [                    ]. The interest so payable will be paid to the
person in whose name this Security is registered at 5 p.m., New York City time, on the day five Business Days immediately preceding such Interest Payment Date (each, a “record date”); provided that, unless this Security
is a Global Security, interest may be paid, at the option of the Company, by mailing a check therefor payable to the registered holder entitled thereto at his last address as it appears on the Register. 

This Security is being deposited with DTC acting as depositary, and registered in the name of Cede & Co., a nominee of DTC.
Cede & Co., as holder of record of this Security, shall be entitled to receive payments of principal and interest, other than principal and interest due upon redemption. Payment of interest on this Security will be made (i) by U.S.
dollar check drawn on a bank in New York City mailed to the registered holder at its registered address or (ii) by wire transfer in immediately available funds to a U.S. dollar account maintained by the registered holder with a bank in New York
City. 
 Reference is made to the further provisions set forth on the reverse hereof. Such further provisions shall for all purposes have
the same effect as though fully set forth at this place. 
 This Security shall not be valid or obligatory until the certificate of
authentication hereon shall have been duly signed by the Trustee acting under the Indenture. 

  
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 IN WITNESS WHEREOF, the Company has caused this instrument to be duly executed. 

Dated: 
  

					
	MITSUBISHI UFJ FINANCIAL GROUP, INC.
		
	By:	 	  

		 	Name:	 	
		 	Title:	 	

  
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 Certificate of Authentication 

This is one of the Global Securities described in the within-mentioned Indenture. 

 

			
	THE BANK OF NEW YORK MELLON
	 as Trustee

		
	By:	 	  

		 	Name:
		 	Title:

  
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 REVERSE OF SECURITY 
  

	1.	General 

 (a) This Security is one of a duly authorized issue of debt securities of the
Company, issued or to be issued pursuant to an indenture dated as of [                    ] (the “Indenture”), duly executed and
delivered by the Company to The Bank of New York Mellon, as Trustee (herein called the “Trustee”). Reference is hereby made to the Indenture and all indentures supplemental thereto for a description of the rights, limitations of
rights, obligations, duties and immunities thereunder of the Trustee, the Company and the holders (the words “holders” or “holder” meaning the registered holders or registered holder) of the Securities. Terms used
herein not otherwise defined shall have the meaning ascribed to such term in the Indenture. 
 (b) The Securities will constitute direct,
unconditional, unsubordinated and unsecured obligations of the Company and rank senior to all of the existing and future subordinated debt of the Company and equally in right of payment with all of the existing and future unsecured and
unsubordinated debt of the Company (except for statutorily preferred exceptions) from time to time outstanding. 
 (c) Certain provisions
herein are summaries of, and subject to, the detailed provisions of the Indenture. 
  

	2.	Calculation and Notification of Interest 

 (a) The Floating Interest Rate (as defined
below) for each Interest Period in respect of the Securities will be determined by the Calculation Agent (as defined below) on the following basis: 

(i) The Bank of New York Mellon, as calculation agent (in such capacity together with any successor, the “Calculation
Agent”) will determine the rate for deposits in U.S. dollars for a period equal or comparable to the relevant Interest Period which appears on the display page designated LIBOR01 on the Reuters service (or any such other page as may
replace that page on that service, or such other service as may be nominated by ICE Benchmark Administration Limited (“ICE”) or its successor, or such other entity assuming the responsibility of ICE or its successor in the event ICE
or its successor no longer does so, as the successor service, for the purpose of displaying comparable rates) as of 11:00 a.m., London time, on the second London Banking Day before the first day of the relevant Interest Period (the “Interest
Determination Date”). 
 (ii) If such rate does not appear on that page, the Calculation Agent will: 

(A) Request the principal London office of each of four major banks selected by the Calculation Agent in the London interbank
market to provide a quotation of the rate at which deposits in U.S. dollars are offered by it at approximately 11:00 a.m., London time, on the Interest Determination Date to prime banks in the London interbank market for a period equal or comparable
to the relevant Interest Period and in an amount that is representative for a single transaction in that market at that time; and 

(B) Determine the arithmetic mean (rounded, if necessary, to the nearest one hundred-thousandth of a percentage point, 0.000005
being rounded upwards) of such quotations. 
 (iii) If fewer than two such quotations are provided as requested, the
Calculation Agent will determine the arithmetic mean (rounded, if necessary as aforesaid) of the rates quoted by major banks in New York City, selected by the Calculation Agent, at approximately 11:00 a.m., New York City time, on the first day of
the relevant Interest Period for loans in U.S. dollars to leading European banks for a period equal or comparable to the relevant Interest Period and in an amount that is representative for a single transaction in that market at that time. 

(b) The floating interest rate for such Interest Period (the “Floating Interest Rate”) shall be a per annum rate equal to the
sum of [        ]% and the rate or the arithmetic mean, as the case may be, determined by one of the methodologies set forth in clauses (2)(a)(i) through 2(a)(iii) hereof; provided, however,
that if the Calculation Agent is unable to determine a rate or an arithmetic mean, as the case may be, in accordance with the above clauses in relation to any Interest Period, the Floating Interest Rate applicable to the Securities during such
Interest Period will be a per annum rate equal to the sum of [        ]% and the rate or the arithmetic mean, as the case may be, applicable in relation to the Securities in respect of the immediately
preceding Interest Period. 

  
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 (c) The Calculation Agent will, as soon as practicable after the determination of the Floating
Interest Rate for each Interest Period in respect of the Securities, calculate the amount of interest (the “Interest Amount”) payable in respect of such Securities for such Interest Period. The Interest Amount will be calculated by
applying the Floating Interest Rate for such Interest Period to the principal amount of such Securities, multiplying the product by the actual number of days in such Interest Period (the “Number of Days”) divided by 360 and rounding
the resulting figure to the nearest cent (half a cent being rounded upwards). 
 (d) The Calculation Agent will cause the Floating Interest
Rate, the actual Number of Days in, and the Interest Amount for, the relevant Interest Period, the record date and the Interest Payment Date, in respect of the Securities to be notified to the Company, the Trustee and DTC, or through DTC or through
other reasonable means to make such information available, in order that such information will be published or notified to the Holders of record as soon as possible after their determination. 

 

	3.	Additional Amounts 

 Subject to certain exceptions as set forth in the Indenture, all
payments of principal and interest in respect of the Securities by the Company shall be made without withholding or deduction for, or on account of, any present or future taxes, duties, assessments or governmental charges of whatever nature imposed
or levied by or on behalf of Japan, or any political sub-division of, or any authority in, or of, Japan having power to tax (“Japanese Taxes”), unless such withholding or deduction is required by law. In that event, the Company
shall pay to the holder of each Security such additional amounts (all such amounts being referred to herein as “Additional Amounts”) as may be necessary so that the net amounts received by it after such withholding or deduction
shall equal the respective amounts which would have been receivable in respect of such Security in the absence of such withholding or deduction, provided that, no Additional Amounts shall be payable in relation to any withholding or deduction
as set forth in the Indenture. 
 No additional amounts will be payable for or on account of any deduction or withholding imposed pursuant
to Sections 1471-1474 of the U.S. Internal Revenue Code of 1986 (or any amended or successor version of such Sections), the U.S. Treasury regulations thereunder and any other official guidance thereunder (“FATCA”), any agreement
(including any intergovernmental agreement) entered into with respect to FATCA, or any law, regulation or other official guidance enacted in any jurisdiction implementing, or relating to, FATCA, similar legislation under the laws of any other
jurisdiction, or any such intergovernmental agreement. 
 References to principal or interest in respect of this Security shall be deemed to
include any Additional Amounts due in respect of Japanese Taxes which may be payable as set forth in this Security and the Indenture. 
  

	4.	Optional Tax Redemption 

 The Securities may, subject to prior confirmation of the
Financial Services Agency of Japan (the “FSA”) (if such confirmation is required under Japanese banking laws and regulations then in effect), be redeemed at the option of the Company, in whole but not in part, at any time, on not
less than 30 nor more than 60 days’ prior notice, at a redemption price equal to 100% of the principal amount of the Securities then outstanding (plus accrued and unpaid interest to (but excluding) the date fixed for redemption and Additional
Amounts, if any), if the Company determines and certifies to the Trustee prior to giving notice of redemption that, as a result of any change in, or amendment to, the laws (or any regulations or rulings promulgated thereunder) of Japan (or any
political subdivision or taxing authority of Japan) affecting taxation, or any change in the official position regarding the application or interpretation of such laws, regulations or rulings (including a holding, judgment, or order by a court of
competent jurisdiction), which change, amendment, application or interpretation becomes effective on or after [                    ], the Company is,
or on the next Interest Payment Date would be, required to pay any Additional Amounts in respect of Japanese Taxes which cannot be avoided by measures reasonably available to the Company; provided that, no such notice of redemption shall be
given earlier than 90 days prior to the earliest date on which the Company would be obligated to make such payment of Additional Amounts if a payment in respect of the Securities were then due. Prior to the mailing of any notice of redemption
of the Securities pursuant to the foregoing, the Company will deliver to the Trustee a certificate signed by a Responsible Officer of the Company stating that the conditions precedent to such redemption have been fulfilled and an opinion of an
independent tax counsel or tax consultant of recognized standing reasonably satisfactory to the Trustee to the effect that the circumstances referred to above exist. The Trustee shall accept such certificate and opinion as sufficient evidence of the
satisfaction of the conditions precedent described above, in which event it shall be conclusive and binding on the Securityholders. 

  
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	5.	Event of Default; Acceleration of Maturity; Waiver of Default 

 In case an Event of
Default, as defined in the Indenture, shall have occurred and be continuing, the entire principal of all the Securities, and the interest accrued thereon, may be declared due and payable immediately, in the manner and with the effect, and subject to
the conditions, provided in the Indenture. The Indenture provides that in certain circumstances such declaration and its consequences may be waived by the holders of a majority in aggregate principal amount of the Securities then Outstanding and
that, prior to any such declaration, such holders may waive any past default under the Indenture and its consequences except a default in the payment of principal of or interest on any of the Securities. Any such consent or waiver by the holder of
this Security (unless revoked as provided in the Indenture) shall be conclusive and binding upon such holder and upon all future holders and owners of this Security and any Security which may be issued in exchange or substitution herefor, whether or
not any notation in regard thereto is made upon this Security or such other Securities. 
  

	6.	Supplemental Indentures 

 The Indenture permits the Company and the Trustee, with the
consent (evidenced as provided in the Indenture) of the holders of not less than a majority in aggregate principal amount of the Securities then Outstanding, to enter into supplemental indentures, from time to time and at any time, for the purpose
of adding any provisions to or changing in any manner or eliminating any of the provisions of the Indenture or of any supplemental indenture or of modifying in any manner the rights of the holders of the Securities; provided, that no such
supplemental indenture shall (a) extend the final maturity of the security or of any installment of principal of any Security, or reduce the principal amount, or reduce the rate or extend the time of payment of interest, or reduce any amount
payable on redemption, or change the currency in which the principal, including any amount of original issue discount, premium, or interest on, any Security, or modify or amend the provisions for conversion of any currency into another currency, or
change any of the Company’s obligations to pay any Additional Amounts, or reduce the amount of any original issue discount security payable upon acceleration or provable in bankruptcy, or impair the right of any holder to institute suit for the
enforcement of any payment on any Security when due, or alter the terms on which holders of any Security may convert or exchange senior debt securities for stock or other securities or for other property or the cash value of the property, other than
in accordance with the anti-dilution provisions or other similar adjustment provisions included in the terms of the Securities; or (b) reduce the aforesaid percentage of Securities, the consent of the holders of which is required for any such
modification of the Indenture, without the consent of the holder of each Security so affected. 
  

	7.	Agreement with Respect to Certain Transfers of Business Under Specified Circumstances 

Notwithstanding anything to the contrary in the Indenture or this Security, the holder of each Security acknowledges, accepts, consents and
agrees that the Indenture will not limit any sales, assignments, transfers or conveyances of business made with the permission of a Japanese court in accordance with Article 126-13 of the Deposit Insurance Act (or any successor provision thereto),
including any such sales, assignments, transfers or conveyances made pursuant to the authority of the Deposit Insurance Corporation to represent and manage and dispose of the Company’s assets under Article 126-5 of the Deposit Insurance Act (or
any successor provision thereto) with the permission of a Japanese court in accordance with Article 126-13 of the Deposit Insurance Act (or any successor provision thereto), which permission may be granted by a Japanese court in accordance therewith
if (i) the Company is under special supervision by, or under special control of, the Deposit Insurance Corporation pursuant to the Deposit Insurance Act, and (ii) the Company’s liabilities exceed, or are likely to exceed, its assets, or the
Company has suspended, or is likely to suspend, payment of its obligations. 

  
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	8.	Denominations; Exchange; Transfer 

 The Securities are issuable only as registered
securities without coupons in minimum principal amounts of $[            ] and in integral multiples of $[            ] in excess
thereof. 
 At the office or agency of the Company referred to on the face hereof or the office of the Trustee or Registrar and in the
manner and subject to the limitations provided in the Indenture, Securities may be exchanged for a like aggregate principal amount of Securities of other authorized denominations. 

Upon due presentment for registration of transfer of this Security at the above-mentioned office or agency of the Company or the office of the
Trustee or Registrar, a new Security or Securities of authorized denominations, for a like aggregate principal amount, will be issued to the transferee as provided in the Indenture. No service charge shall be made for any such transfer, but the
Company or the Trustee may require payment of a sum sufficient to cover any duty, tax or governmental charge or insurance charge that may be imposed in relation thereto. 
  

	9.	Holders to Be Treated as Owners 

 The Company, the Trustee and any authorized agent of
the Company or the Trustee may deem and treat the registered holder hereof as the absolute owner of this Security (whether or not this Security shall be overdue and notwithstanding any notation of ownership or other writing hereon made by anyone
other than the Company or the Trustee or any authorized agent of the Company or the Trustee), for the purpose of receiving payment of, or on account of, the principal hereof and, subject to the provisions on the face hereof and the Indenture,
interest hereon and for all other purposes, and neither the Company nor the Trustee nor any authorized agent of the Company or the Trustee shall be affected by any notice to the contrary. 

 

	10.	Incorporators, Stockholders, Officers and Directors of Company Exempt from Individual Liability 

No recourse under or upon any obligation, covenant or agreement contained in the Indenture, or herein, or because of any Indebtedness evidenced
thereby, shall be had against any incorporator, as such, or against any past, present or future stockholder, executive officer or director, as such, of the Company or of any successor, either directly or through the Company or any successor, under
any rule of law, statute or constitutional provision or by the enforcement of any assessment or by any legal or equitable proceeding or otherwise, all such liability being, by the acceptance hereof and as part of the consideration for the issue
hereof, expressly waived and released. 
  

	11.	Governing Law 

 This Security and the rights of the holder hereof shall be governed by
and construed in accordance with the laws of the State of New York. 

  
 9Exhibit 10.8

 

PROTEO, INC.

PREFERRED STOCK PURCHASE AGREEMENT

 

This Preferred Stock Purchase Agreement (“Agreement”)
is made this ninth (9th) day of September, 2016 by and between PROTEO, INC., a Nevada corporation with its principal
place of business at 2102 Business Center Drive, Irvine, CA 92612 (the “Company”), and the purchaser of its
stock, CFI Innovation GmbH Berlin Unternehmensberatung und Beteiligungen, a German corporation with its principal place of business
at Normannenstraße 4, 14129 Berlin, Germany (“Purchaser”).

 

RECITALS

 

		A.	The Company is engaged in research and development of pharmaceuticals.
The Company now is willing to sell shares of its Series B-1 Preferred stock, on terms as stated herein.

 

		B.	The Company has authorized 300,000,000 shares of common stock and 10,000,000 shares of preferred
stock. Currently, 23,879,350 shares of the Company’s common stock are issued and outstanding. Currently, 723,590 shares of
the Company’s Series A Preferred Stock are issued and outstanding. The Company has designated 1,000,000 shares of preferred
stock as Series B-1 Preferred Stock, which voting powers, preferences and other rights are set forth in the Certificate of Designation
of Series B-1 Preferred Stock, a copy of which is attached hereto as Exhibit A.

 

		C.	The sale of shares as stipulated herein is part of the attempt of the company to finance development
activities related to ELAFIN. This Agreement is intended to be a first tranche of equity financing participation of Purchaser.
The parties may negotiate additional sales of the Company’s preferred stock to Purchaser after each of the parties’
complete fulfillment of its obligations under this Agreement and Purchaser’s payment of the purchase price for all of the
shares of Series B-1 Preferred Stock purchased pursuant to this Agreement.

 

		D.	Purchaser and the Company mutually desire for Purchaser to purchase 1,000,000 shares of the Company’s
Series B-1 Preferred Stock at the purchase price and on the other terms and conditions stated herein.

 

AGREEMENT

 

In consideration of the mutual promises, representations,
warranties and conditions set forth in this Agreement, the Company and Purchaser agree as follows:

 

	1.	 	Purchase and Sale of Shares.

 

		1.1	Sale of Shares. The Company and its Board of Directors has authorized the issuance
and sale of 1,000,000 shares of Series B-1 Preferred Stock (the “Purchase Shares”) pursuant to the terms of
this Agreement. In reliance upon Purchaser’s representations and warranties contained in Section 4 hereof, and subject
to the terms and conditions set forth herein, the Company hereby agrees to sell to Purchaser, and Purchaser agrees to buy from
the Company, the Purchase Shares.

 

		1.2	Price per Share. The price per share shall be EUR 1.00 per share, totaling EUR 1,000,000
for the Purchase Shares (the “Purchase Price”).

 

		1.3	Rebate. In partial consideration for Purchaser agreeing to purchase the Purchase
Shares from the Company, the Company agrees to rebate four percent (4%) of the Purchase Price paid to the Company prior to March
31, 2017 on each of June 30, 2017, June 30, 2018, and June 30, 2019 (the “Rebate Dates”). For example, assuming
the entire Purchase Price is paid pursuant to the terms of this Agreement prior to March 31, 2017, the Company shall rebate EUR
40,000 to Purchaser on each of the Rebate Dates.

 

	2.		Closing: Issuance and Delivery
of Shares: Conditions.

 

		2.1	Initial Closing. On October 31, 2016 or on such earlier date as the parties may agree
(the “Initial Closing Date”), the Company agrees to issue and sell, and Purchaser agrees to purchase from the
Company, 100,000 of the Purchase Shares. Purchaser shall deliver EUR 100,000, which is the Purchase Price with respect to such
Purchase Shares, by wire transfer or by other means of payment as shall have been agreed upon by the Purchaser and the Company
prior to payment on or before the Initial Closing Date.

 

		2.2	Subsequent Closing(s). The Company agrees to issue and sell, and Purchaser agrees
to purchase from the Company, the remaining 900,000 Purchase Shares on the fifth (5th) business day after such date
or dates that Purchaser delivers the Purchase Price by wire transfer or by other means of payment as shall have been agreed upon
by the Purchaser and the Company prior to payment of immediately available funds to the Company for such Purchase Shares; provided,
however, that Purchaser shall deliver the Purchase Price for all Purchase Shares on or before March 31, 2017. For the purposes
of this Agreement, after the Initial Closing Date, each fifth (5th) business day after Purchaser delivers all or a portion
of the Purchase Price to Company is a “Subsequent Closing Date.”

 

 

    	 	1	 

     

    

 

		2.3	Delivery of Certificates. On or prior to the Initial Closing Date and each Subsequent
Closing Date (each, a “Closing Date”), subject to the terms and conditions hereof, and conditioned upon receipt
of the Purchase Price with respect thereto, the Company shall deliver to the Purchaser stock certificates representing the applicable
Purchase Shares registered in the name of Purchaser.

 

		2.4	Acknowledgement. The
parties acknowledge and agree that the offer and sale of the Purchase Shares has occurred outside of the United States.

 

	3.	 	Representations and Warranties of the Company. The Company hereby represents and warrants
to Purchaser as of the date hereof as follows, and all such representations and warranties shall be true and correct as of any
Closing Date as if then made and shall survive such closing.

 

		3.1	Organization. The Company is a corporation, duly incorporated, validly existing and
in good standing under the laws of Nevada. The Company has all requisite power and authority to own or lease its properties and
to conduct its business as now conducted. The Company holds all licenses and permits required for the conduct of its business as
now conducted, which, if not obtained, would have a material adverse effect on the business, financial condition or results of
operations of the Company taken as a whole. The Company is qualified as a foreign corporation and is in good standing in any states
where the conduct of its business or its ownership or leasing of property requires such qualification, except where the failure
to so qualify would not have a material adverse effect on the business, financial condition or results of operations of the Company
taken as a whole.

 

		3.2	Capitalization. The Company is authorized to issue 300,000,000 shares of Common Stock
of which 23,879,350 shares are outstanding at the date of this Agreement. The Company is authorized to issue 10,000,000 shares
of Preferred Stock of which 723,590 shares are outstanding at the date of this Agreement. All of the issued and outstanding shares
of Common Stock and Preferred Stock on the Closing Date are or will have been duly authorized, validly issued and then fully paid
and non-assessable. The Company’s right to issue shares of its stock otherwise shall not be limited by any provision herein.

 

		3.3	Authority. The Company has all requisite power and authority to enter into this Agreement,
and to consummate the transactions contemplated hereby. The execution and delivery of this Agreement, and the consummation of the
transactions contemplated hereby have been duly authorized by all necessary corporate action on the part of the Company, and upon
their execution and delivery by the Company, such document will constitute a valid and binding obligation of the Company, enforceable
against the Company in accordance with its terms.

 

		3.4	Issuance of Shares. The Purchase Shares, when issued pursuant to the terms of this
Agreement, will be duly and validly authorized and issued, fully paid and non-assessable.

 

		3.5	No Conflict with Law or Documents. The execution, delivery and consummation of this
Agreement, and the transactions contemplated hereby, will not (a) conflict with any provisions of the Articles of Incorporation
or Bylaws of the Company; (b) result in any violation of or default or loss of a benefit under, or permit the acceleration of any
obligation under (in each case, upon the giving of notice, the passage of time, or both), any mortgage, indenture, lease, agreement
or other instrument, permit, franchise license, judgment, order, decree, law, ordinance, rule or regulation applicable to the Company,
except where such violation or default would not have a material adverse effect on the business, financial condition or results
of operations of the Company taken as a whole.

 

		3.6	Consents, Approvals and Private Offering. Except for any filings required under federal
and applicable state securities laws, all of which shall have been made as of the Closing Date to the extent required as of such
time, no permit, consent, approval, order or authorization of, or registration, declaration or filing with, any federal, state,
local or foreign governmental authority is required to be made or obtained by the Company in connection with the execution and
delivery of this Agreement, and the consummation of the transactions contemplated hereby and thereby.

 

 

    	 	2	 

     

    

 

	4.	 	Representations and Warranties of Purchaser. Purchaser hereby represents, warrants
and covenants with the Company as follows:

 

		4.1	Legal Power. Purchaser has the requisite power, as appropriate, and is authorized
to enter into this Agreement, to purchase the Purchase Shares hereunder, and to carry out and perform his, her or its obligations
under the terms of this Agreement.

 

		4.2	Due Execution. This
Agreement has been duly authorized, executed and delivered by Purchaser, and, upon due execution and delivery by the Company,
this Agreement will be a valid and binding agreement of Purchaser.

 

		4.3	Investment Representations.
Purchaser represents and agrees that:

 

		4.3.1	The Purchase Shares have not been and will not be registered under the U.S. Securities
Act of 1933, as amended (the “Securities Act”), and may not be offered or sold within the United States or to,
or for the account or benefit of, U.S. persons except in accordance with Regulation S or pursuant to an exemption from the registration
requirements of the Securities Act. Each Purchaser represents, warrants and undertakes that (i) none of the owners of Purchaser
are or will be U.S. persons, and (ii) it has not offered or sold, and will not offer and sell any securities (a) as part of their
distribution at any time and (b) otherwise until one (1) year after the later of the commencement of the Offering and the Closing
Date, except in accordance with Regulation S, and it has not and will not engage in any hedging transactions involving the
securities unless in compliance with the Securities Act. Each Purchaser also agrees that, at or prior to confirmation of sale of
Purchase Shares, it will have sent to each distributor, dealer or person receiving a selling concession, fee or other remuneration
that purchases securities from it during the distribution compliance period a confirmation or notice to substantially the following
effect:

 

“The securities covered hereby have not
been registered under the U.S. Securities Act of 1933, as amended (the “Securities Act”), and may not be offered or
sold within the United States or to, or for the account or benefit of, U.S. persons (i) as part of their distribution at any time
or (ii) otherwise until one (1) year after the later of the commencement of the offering and the closing date, except in either
case in accordance with Regulation S under the Securities Act. No hedging transaction can be conducted with regard to the securities
except as permitted by the Securities Act. Terms used above have the meanings given to them by Regulation S.”

 

Terms used in this Section 4.3.1 have
the meanings given to them by Regulation S.

 

		4.3.2	Purchaser is able to bear the risks associated with accepting the Purchase Shares, including
the risk of loss of the entire investment in the Purchase Shares. Purchaser has received and reviewed any and all information Purchaser
deemed necessary to evaluate its investment.

 

		4.3.3	Purchaser understands that the Purchase Shares have not been registered under the Act
by reason of a specific exemption therefrom, and may not be transferred or resold except pursuant to an effective registration
statement or exemption from registration and each certificate representing the Purchase Shares will be endorsed with the following
legends:

 

		(a)	THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “ACT”). THE SHARES HAVE BEEN ACQUIRED FOR INVESTMENT AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED
OR OTHERWISE DISPOSED OF IN THE ABSENCE OF A CURRENT AND EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT WITH RESPECT TO SUCH SHARES,
OR AN OPINION OF THE ISSUER’S COUNSEL TO THE EFFECT THAT REGISTRATION IS NOT REQUIRED UNDER THE ACT; and

 

		(b)	Any legend required to be placed thereon by applicable federal or state securities laws.

 

		4.3.4	Purchaser has read, and understands and agrees to the Certificate of Designation of Series
B-1 Preferred Stock attached hereto as Exhibit A.

 

 

    	 	3	 

     

    

 

	5.		Term and Termination.

 

		5.1	Term. This Agreement
shall expire upon total payment of the Purchase Price and issuance of the Purchase Shares to Purchaser. Purchaser’s representations,
warranties, and covenants shall survive the termination of this Agreement.

 

		5.2	The Company may cancel this agreement upon:

 

		(a)	(any misrepresentation or omission of or on behalf of Purchaser made to the Company in connection
with this Agreement;

 

		(b)	adjudication of bankruptcy, or filing of a petition under any bankruptcy or debtor’s
relief law by or against Purchaser, or failure of Purchaser to generally pay its debts as they become due; or

 

		(c)	failure of Purchaser to pay the Purchase Price prior to March 31, 2017.

 

		5.3	The right to cancel the agreement according to Section 5.2 shall be limited to the
remaining agreement not fulfilled at the date of the intended cancellation. 

 

	6.	 .	Miscellaneous.

 

		6.1	Governing Law. This
Agreement shall be governed by and construed under the laws of the State of California.

 

		6.2	Successors and Assigns. Except as otherwise expressly provided herein, the provisions
hereof shall inure to the benefit of, and are binding upon, the successors, assigns, heirs, executors, and administrators of the
parties hereto.

 

		6.3	Entire Agreement.
This Agreement and the other documents delivered pursuant hereto constitute the full and entire understanding and agreement
between the parties with regard to the subjects hereof and no party shall be liable or bound to any other party in any manner
by any representations, warranties, covenants, or agreements except as specifically set forth herein or therein. Nothing in this
Agreement, express or implied, is intended to confer upon any party, other than the parties hereto and their respective successors
and assigns, any rights, remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly provided
herein.

 

		6.4	Severability. In case
any provision of this Agreement shall be invalid, illegal, or unenforceable, it shall, to the extent practicable, be modified
so as to make it valid, legal and enforceable and to retain as nearly as practicable the intent of the parties, and the validity,
legality, and enforceability of the remaining provisions shall not in any way be affected or impaired thereby.

 

		6.5	Amendment and Waiver. Except as otherwise provided herein, any term of this Agreement
may be amended, and the observance of any term of this Agreement may be waived (either generally or in a particular instance, either
retroactively or prospectively, and either for a specified period of time or indefinitely), with the written consent of the Company
and Purchaser. Any amendment or waiver effected in accordance with this Section shall be binding upon each future holder of any
security purchased under this Agreement (including securities into which such securities have been converted) and the Company.

 

		6.6	Notices. All notices and other communications required or permitted hereunder shall be in
writing and shall be effective when delivered personally, or when sent by registered mail, return receipt requested, or when received
by the addressee, if sent by Express Mail, Federal Express or other express delivery service (receipt request) in each case to
the appropriate address set forth below.

 

	If to the Company:	PROTEO, INC.

ATTN: CEO

2102 Business Center Drive

Irvine, CA 92612
	 	 
	If to Purchaser:	CFI Innovation GmbH

Normannenstraße 4,

14129 Berlin, Germany
	 	 

 

		6.7	Titles and Subtitles. The titles of paragraphs and subparagraphs of this Agreement
are for convenience of reference only and are not to be considered in construing this Agreement.

 

		6.8	Counterparts. This Agreement may be executed in any number of counterparts, each
of which shall be deemed an original, but all of which together shall constitute one instrument.

 

[The remainder of this page has been intentionally
left blank.]

 

 

    	 	4	 

     

    

IN WITNESS WHEREOF, the parties have executed
this Agreement on the date first above written.

 

	“COMPANY”	“PURCHASER”
	PROTEO, INC.,

a Nevada corporation 	CFI INNOVATION GMBH BERLIN UNTERNEHMENSBERATUNG UND BETEILIGUNGEN, a German corporation
	By: /s/ Birge Bargmann

Name: Birge Bargmann

Title: President and CEO 	By: /s/ Jork von Reden

Name: Jork von Reden

Title:  Managing Director
	 	 

 

 

 

 

 

 

 

 

 

 

 

 

 

    	 	5	 

     

    

EXHIBIT A

CERTIFICATE OF DESIGNATION OF SERIES B-1 PREFERRED STOCK

 

Exhibit A

 

CERTIFICATE OF DESIGNATION OF SERIES B-1 PREFERRED
STOCK

 

OF

 

PROTEO, INC.

A NEVADA CORPORATION

 

 

Proteo, Inc., a Nevada
corporation (the “Corporation”), hereby certifies that the following resolution was adopted by the Board of
Directors of the Corporation:

 

RESOLVED, that pursuant
to the authority vested in the Board of Directors of this Corporation (the “Board of Directors”) in accordance
with the provisions of the Articles of Incorporation of the Corporation, there is hereby created, a series of Preferred Stock consisting
of 1,000,000 shares, which series shall have the following powers, designations, preferences and relative, participating, optional
and other special rights, and the following qualifications, limitations and restrictions as follows:

 

Section 1.  DESIGNATION
AND AMOUNT. The shares of Preferred Stock created hereby shall be designated as “Series B-1 Preferred Stock” and the
authorized number of shares constituting such series shall be 1,000,000.

 

Section 2.  DIVIDENDS
AND DISTRIBUTIONS.

(A)  The
holders of the then outstanding shares of Series B-1 Preferred Stock shall be entitled to receive, when, as and if declared by
the Board of Directors, out of funds of the Corporation legally available therefore, preferential dividends at the per share rate
of one point five (1.5) times the per share amount of each and any cash and non-cash dividend distributed to holders of the Corporation’s
Common Stock when, as and if declared by the Board of Directors. In the event, the Company shall (i) subdivide the outstanding
Common Stock, or (ii) combine the outstanding Common Stock into a smaller number of shares by a reverse stock split or otherwise,
the amount set forth in the preceding sentence shall be adjusted at the same rate.

(B)  No dividend
shall be paid or declared on any share of Common Stock or Series A Preferred Stock, unless a dividend, payable in the same consideration
and manner, is simultaneously paid or declared, as the case may be, on each share of Series B-1 Preferred Stock in an amount determined
as set forth in paragraph (A) above. For purposes hereof, the term “dividends” shall include any pro rata distribution
by the Corporation, out of funds of the Corporation legally available therefore, of cash, property, securities (including, but
not limited to, rights, warrants or options) or other property or assets to the holders of the Common Stock, whether or not paid
out of capital, surplus or earnings.

 

(C)  The Board
of Directors may fix a record date for the determination of holders of shares of Series B-1 Preferred Stock entitled to receive
any dividend or distribution as provided in Paragraph (A) above.

 

Section 3.  VOTING
RIGHTS. Except as otherwise required by law, the shares of Series B-1 Preferred Stock shall have no voting rights. Except as otherwise
required by law, the Series B-1 Preferred Stock shall not be entitled to vote as a separate class on any matter to be voted on
by stockholders of the Corporation.

 

Section 4.  REACQUIRED
SHARES. Any shares of Series B-1 Preferred Stock purchased or otherwise acquired by the Company in any manner whatsoever shall
be retired and cancelled promptly after the acquisition thereof. All such shares shall upon their cancellation become authorized
but unissued shares of Preferred Stock and may be reissued as part of Series B-1 Preferred Stock or of any other series of Preferred
Stock as designated by the Board of Directors from time to time.

 

Section 5.  LIQUIDATION,
DISSOLUTION OR WINDING UP. Upon any liquidation, voluntary or otherwise, dissolution or winding up of the Company, holders of Series
B-1 Preferred Stock shall be entitled to receive per share distributions equal to one point five (1.5) times the rate of per share
distributions to be made to the holders of Common Stock. No distributions shall be made unless any accrued and unpaid dividends
and distributions on the Series B-1 Preferred Stock have been made prior thereto. In the event, the Company shall have (i) subdivided
the outstanding Common Stock, or (ii) combined the outstanding Common Stock into a smaller number of shares by a reverse stock
split or otherwise, after the issuance of Series B-1 Preferred Stock, distributions payable to Series B-1 Preferred Stock under
this Section 5 shall be adjusted accordingly.

 

    	 	A-1	 

     

    

 

Section 6.  CONSOLIDATION;
MERGER; ETC. In the event the Company shall enter into any consolidation, merger combination or other transaction in which the
shares of Common Stock are exchanged into other stock or securities, cash and /or any other property, then in any such case each
share of Series B-1 Preferred Stock shall automatically be simultaneously exchanged for or converted into the same stock or securities,
cash and/or other property at a rate per share equal to one point five (1.5) times the rate per share that the Common Stock is
being exchanged or converted. In the event, the Company shall (i) subdivide the outstanding Common Stock, or (ii) combine the outstanding
Common Stock into a smaller number of shares by a reverse stock split or otherwise, the amount set forth in the preceding sentence
shall be adjusted at the same rate.

 

Section
7.  REDEMPTION.  The shares of Series B-1 Preferred Stock shall not be redeemable.

 

Section 8.  RANKING.
The Series B-1 Preferred Stock shall rank equal to the Series A Preferred Stock as to the payment of dividends and the distribution
of assets. The Series B-1 Preferred Stock may rank junior to any other series of the Corporation’s Preferred Stock as to
the payment of dividends and the distribution of assets as may be determined in the designation of any such series of Preferred
Stock.

  

Section 9.  AMENDMENT.
At any time when any shares of Series B-1 Preferred Stock are outstanding, neither the Articles of Incorporation of the Corporation
nor this Certificate of Designation shall be amended or altered in any manner which would materially alter or change the powers,
preferences or special rights of the Series B-1 Preferred Stock so as to affect them adversely without the affirmative vote of
holders representing a majority of the outstanding shares of Series B-1 Preferred Stock, voting separately as a class.

   

IN WITNESS WHEREOF, the
undersigned have executed this Certificate and do affirm the foregoing as true and correct this 5th day of September
2016.

 

 

 

/s/ Birge Bargmann

Birge Bargmann

President, CEO and CFO

 

 

 

	 	Attest:
	 	 
	 	 
	 	/s/ Oliver Wiedow
	 	Oliver Wiedow
	 	Secretary

 

 

 

A-2

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