Document:

EX-10.12

 Exhibit 10.12 

KALEIDO BIOSCIENCES, INC. 

LOAN AND SECURITY AGREEMENT 

 This LOAN AND SECURITY AGREEMENT (the “Agreement”) is entered into as of December 21, 2015,
by and between PACIFIC WESTERN BANK, a California state chartered bank (“Bank”) and KALElDO BIOSCIENCES, INC. (“Borrower”). 

RECITALS 
 Borrower wishes to obtain
credit from time to time from Bank, and Bank desires to extend credit to Borrower. This Agreement sets forth the terms on which Bank will advance credit to Borrower, and Borrower will repay the amounts owing to Bank. 

AGREEMENT 
 The parties agree as follows:

  

	1.	 DEFINITIONS AND CONSTRUCTION. 

1.1      Definitions. As used in this Agreement, all capitalized terms shall have the definitions
set forth on Exhibit A. Any term used in the Code and not defined herein shall have the meaning given to the term in the Code. 

1.2      Accounting Terms. Any accounting term not specifically defined on Exhibit A shall be
construed in accordance with GAAP and all calculations shall be made in accordance with GAAP (except for noncompliance with FAS 123R in monthly reporting). The term “financial statements” shall include the accompanying notes and schedules.

  

	2.	 LOAN AND TERMS OF PAYMENT. 

2.1      Credit Extensions. 

(a)      Promise to Pay. Borrower promises to pay to Bank, in lawful money of the United States of
America, the aggregate unpaid principal amount of all Credit Extensions made by Bank to Borrower, together with interest on the unpaid principal amount of such Credit Extensions at rates in accordance with the terms hereof. 

(b)      Term Loans. 

(i)      Subject to and upon the terms and conditions of this Agreement, (I) Borrower may request
and Bank agrees to make one or more term loans to Borrower in an aggregate original principal amount not to exceed $2,500,000 (each a “Tranche A Term Loan” and collectively the “Tranche A Term Loans”) at any time from the Closing
Date through the Availability End Date and (II) Borrower may request and Bank agrees to make one or more additional term loans to Borrower in an aggregate original principal amount not to exceed $2,500,000 (each a “Tranche B Term
Loan” and collectively, the “Tranche B Term Loans” and together with the Tranche A Term Loans, each a “Term Loan” and collectively, the “Term Loans”) at any time from the date Borrower achieves the Tranche B
Milestones through the Availability End Date. The proceeds of the Term Loans shall be used for general working capital purposes and for capital expenditures. 

(ii)      Interest shall accrue from the date of each Term Loan at the rate specified in
Section 2.3(a), and prior to June 21, 2017 shall be payable monthly in arrears beginning on the 21st day of the month next following the such Term Loan, and continuing on the same day of each month thereafter. Any Term Loans that are
outstanding on June 21, 2017 shall be payable in 30 equal monthly installments of principal, plus all accrued interest, beginning on July 21, 2017, and continuing on the same day of each month thereafter through the Term Loan Maturity
Date, at which time all amounts due in connection with the Term Loans and any other amounts due under this Agreement shall be immediately due and payable. Term Loans, once repaid, may not be reborrowed. Borrower may prepay any Term Loan in whole or
in part at any time without penalty or premium. 

  
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 (iii)      When Borrower desires to obtain a Term Loan
(other than the initial Term Loan), Borrower shall notify Bank (which notice shall be irrevocable) by facsimile transmission to be received no later than 3:30 p.m. Eastern time on the Business Day prior to the date on which the Term Loan is to be
made. Such notice shall be substantially in the form of Exhibit C. The notice shall be signed by an Authorized Officer. 

2.2      Intentionally Omitted. 

2.3      Interest Rates, Payments, and Calculations. 

(a)      Interest Rate. Except as set forth in Section 2.3(b), the Term Loans shall bear
interest, on the outstanding daily balance thereof, at a variable annual rate equal to the greater of (A) 0.75% above the Prime Rate then in effect, or (B) 4.00%. 

(b)      Late Fee; Default Rate. If any payment is not made within 15 days after the date such
payment is due, Borrower shall pay Bank a late fee equal to the lesser of (i) 5% of the amount of such unpaid amount or (ii) the maximum amount permitted to be charged under applicable law. All outstanding Obligations shall bear interest, from
and after the occurrence and during the continuance of an Event of Default, at a rate equal to 5 percentage points above the interest rate applicable immediately prior to the occurrence of the Event of Default. 

(c)      Payments. Interest under the Term Loans shall be due and payable monthly in arrears on
the 21st calendar day of each month during the term hereof. Bank shall, at its option, charge such interest, all Bank Expenses, and all Periodic Payments against any of Borrower’s deposit accounts. Any interest not paid when due shall be
compounded by becoming a part of the Obligations, and such interest shall thereafter accrue interest at the rate then applicable hereunder. 

(d)      Computation. In the event the Prime Rate is changed from time to time hereafter, the
applicable rate of interest hereunder shall be increased or decreased, effective as of the day the Prime Rate is changed, by an amount equal to such change in the Prime Rate. All interest chargeable under the Loan Documents shall be computed on the
basis of a 360 day year for the actual number of days elapsed. 
 2.4      Crediting Payments.
Prior to the occurrence and continuance of an Event of Default, Bank shall credit a wire transfer of funds, check or other item of payment to such deposit account or Obligation as Borrower specifies. After the occurrence and during the
continuance of an Event of Default, Bank shall have the right, in its sole discretion, to immediately apply any wire transfer of funds, check, or other item of payment Bank may receive to conditionally reduce Obligations, but such applications of
funds shall not be considered a payment on account unless such payment is of immediately available federal funds or unless and until such check or other item of payment is honored when presented for payment. Notwithstanding anything to the contrary
contained herein, any wire transfer or payment received by Bank after 5:30 p.m. Eastern time shall be deemed to have been received by Bank as of the opening of business on the immediately following Business Day. Whenever any payment to Bank under
the Loan Documents would otherwise be due (except by reason of acceleration) on a date that is not a Business Day, such payment shall instead be due on the next Business Day, and additional fees or interest, as the case may be, shall accrue and be
payable for the period of such extension. 
 2.5      Bank Expenses. Borrower shall pay to Bank,
on the Closing Date, all Bank Expenses incurred through the Closing Date, and, after the Closing Date, all Bank Expenses, as and when they become due. 

2.6      Term. This Agreement shall become effective on the Closing Date and, subject to
Section 12.7, shall continue in full force and effect for so long as any Obligations (other than inchoate indemnification obligations) remain outstanding or Bank has any obligation to make Credit Extensions under this Agreement. Notwithstanding
the foregoing, Bank shall have the right to terminate its obligation to make Credit Extensions under this Agreement immediately and without notice upon the occurrence and during the continuance of an Event of Default. 

  
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	3.	 CONDITIONS OF LOANS. 

3.1      Conditions Precedent to Closing. The agreement of Bank to enter into this Agreement on the
Closing Date is subject to the condition precedent that Bank shall have received, in form and substance satisfactory to Bank, each the following items and completed each of the following requirements: 

(a)      this Agreement; 

(b)      an officer’s certificate of Borrower with respect to incumbency and resolutions authorizing
the execution and delivery of this Agreement; 
 (c)      a financing statement (Form UCC-1); 
 (d)      payment of the fees and Bank Expenses then due
specified in Section 2.5, which may be debited from any of Borrower’s accounts with Bank; 

(e)      current SOS Reports indicating that except for Permitted Liens, there are no other security
interests or Liens of record in the Collateral; 
 (f)      current financial statements, including
company prepared statements for Borrower’s most recently ended fiscal year, company prepared consolidated and consolidating balance sheets, income statements and statements of cash flows for the most recently ended month in accordance with
Section 6.2, and such other updated financial information as Bank may reasonably request; 

(g)      current Compliance Certificate in accordance with Section 6.2; 

(h)      a warrant in form and substance satisfactory to Bank; 

(i)      a Borrower Information Certificate; 

(j)      such other documents or certificates, and completion of such other matters, as Bank may have
reasonably requested; and 
 (k)      Borrower shall have opened and funded not less than $50,000 in
deposit accounts held with Bank. 
 3.2      Conditions Precedent to all Credit Extensions. The
obligation of Bank to make each Credit Extension, including the initial Credit Extension, is contingent upon the Borrower’s compliance with Section 3.1 above, and is further subject to the following conditions: 

(a)      timely receipt by Bank of the Loan Advance/Paydown Request Form as provided in Section 2.1;

 (b)      Borrower shall have transferred substantially all of its Cash assets into operating
accounts held with Bank and otherwise be in compliance with Section 6.6 hereof; 
 (c)      in
Bank’s sole but reasonable discretion, there has not been a Material Adverse Effect; and 

(d)      the representations and warranties contained in Section 5 shall be true and correct in all
material respects on and as of the date of such Loan Advance/Paydown Request Form and on the effective date of each Credit Extension as though made at and as of each such date, and no Event of Default shall have occurred and be continuing, or would
exist after giving effect to such Credit Extension (provided, however, that those representations and warranties expressly referring to another date shall be true, correct and complete in all material respects as of such date). The making of each
Credit Extension shall be deemed to be a representation and warranty by Borrower on the date of such Credit Extension as to the accuracy of the facts referred to in this Section 3.2. 

  
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	4.	 CREATION OF SECURITY INTEREST. 

4.1      Grant of Security Interest. Borrower grants and pledges to Bank a continuing security
interest in the Collateral to secure prompt repayment of any and all Obligations and to secure prompt performance by Borrower of each of its covenants and duties under the Loan Documents (other than any warrants or equity related agreements). Except
for Permitted Liens or as disclosed in the Schedule, such security interest constitutes a valid, first priority security interest in the presently existing Collateral, and will constitute a valid, first priority security interest in later-acquired
Collateral. Borrower also hereby agrees not to sell, transfer, assign, mortgage, pledge, lease, grant a security interest in, or encumber any of its Intellectual Property, except for Permitted Transfers and Permitted Liens. Notwithstanding any
termination of this Agreement or of any filings undertaken related to Bank’s rights under the Code, Bank’s Lien on the Collateral shall remain in effect for so long as any Obligations (other than inchoate indemnification obligations) are
outstanding. 
 4.2      Perfection of Security Interest. Borrower authorizes Bank to file at
any time financing statements, continuation statements, and amendments thereto that (i) either specifically describe the Collateral or describe the Collateral as all assets of Borrower of the kind pledged hereunder, and (ii) contain any
other information required by the Code for the sufficiency of filing office acceptance of any financing statement, continuation statement, or amendment, including whether Borrower is an organization, the type of organization and any organizational
identification number issued to Borrower, if applicable. Borrower shall have possession of the Collateral, except where expressly otherwise provided in this Agreement or where Bank chooses to perfect its security interest by possession in addition
to the filing of a financing statement. Where Collateral is in possession of a third party bailee, Borrower shall take such steps as Bank reasonably requests for Bank to (i) to the extent required in Section 7.11 below, obtain an
acknowledgment, in form and substance reasonably satisfactory to Bank, of the bailee that the bailee holds such Collateral for the benefit of Bank, and (ii) to the extent required under Section 6.6 below, obtain “control” of any
Collateral consisting of investment property, deposit accounts, letter-of-credit rights or electronic chattel paper (as such items and the term “control” are
defined in Revised Article 9 of the Code) by causing the securities intermediary or depositary institution or issuing bank to execute a control agreement in form and substance satisfactory to Bank. Borrower will not create any chattel paper without
placing a legend on the chattel paper acceptable to Bank indicating that Bank has a security interest in the chattel paper. Borrower from time to time, pursuant to additional agreements by Borrower, may deposit with Bank specific cash collateral to
secure specific Obligations; Borrower authorizes Bank to hold such specific balances in pledge and to decline to honor any drafts thereon or any request by Borrower or any other Person to pay or otherwise transfer any part of such balances for so
long as the specific Obligations are outstanding. Borrower shall take such other actions as Bank reasonably requests to perfect its security interests granted under this Agreement. 

 

	5.	 REPRESENTATIONS AND WARRANTIES. 

Borrower represents and warrants as follows: 

5.1      Due Organization and Qualification. Borrower and each Subsidiary is duly existing under
the laws of the state in which it is organized and qualified and licensed to do business in any state in which the conduct of its business or its ownership of property requires that it be so qualified, except where the failure to do so would not
reasonably be expected to cause a Material Adverse Effect. 
 5.2      Due Authorization; No
Conflict. The execution, delivery, and performance of the Loan Documents are within Borrower’s powers, have been duly authorized, and are not in conflict with nor constitute a breach of any provision contained in Borrower’s Certificate
of Incorporation or Bylaws, nor will they constitute an event of default under any material agreement by which Borrower is bound. Borrower is not in default under any agreement by which it is bound, except to the extent such default would not
reasonably be expected to cause a Material Adverse Effect. 
 5.3      Collateral. Borrower has
rights in or the power to transfer the Collateral, and its title to the Collateral is free and clear of Liens, adverse claims, and restrictions on transfer or pledge except for Permitted 

  
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Liens. Other than movable items of personal property such as laptop computers, all Collateral having an aggregate book value in excess of $250,000 is located solely in the Collateral States, at
the locations set forth on Schedule 7.11 and such other locations permitted under Section 7.11. All finished goods Inventory is in all material respects of good and merchantable quality, free from all material defects, except for Inventory for
which adequate reserves have been made. Except as set forth in the Schedule, none of the Borrower’s Cash is maintained or invested with a Person other than Bank or Bank’s affiliates or as permitted under Section 6.6. 

5.4      Intellectual Property. Borrower’s registered Intellectual Property as of the Closing
Date is set forth on Schedule 5.4 hereto. Borrower is the sole owner of the intellectual property created or purchased or licensed by Borrower, except for any rights of a licensor of intellectual property purchased or licensed by Borrower, licenses
granted by Borrower in the ordinary course of business and other Permitted Transfers. To Borrower’s knowledge, each of the material copyrights, trademarks and patents created or purchased by Borrower is valid and enforceable, and no part of the
intellectual property created or purchased by Borrower has been judged invalid or unenforceable, in whole or in part, and no claim has been made to Borrower in writing that any part of the intellectual property created or purchased by Borrower
violates the rights of any third party except to the extent such judgment or claim would not reasonably be expected to cause a Material Adverse Effect. 

5.5      Name; Location of Chief Executive Office. Except as disclosed in the Schedule, Borrower
has not done business under any name other than that specified on the signature page hereof, and its exact legal name is as set forth in the first paragraph of this Agreement. As of the date hereof, the chief executive office of Borrower is located
at the address indicated in Section 10 hereof. 
 5.6      Litigation. Except as set forth
in the Schedule, there are no actions or proceedings pending by or against Borrower or any Subsidiary before any court or administrative agency in which a likely adverse decision would reasonably be expected to have a Material Adverse Effect. 

5.7      No Material Adverse Change in Financial Statements. All consolidated and consolidating
(if any) financial statements related to Borrower and any Subsidiary that are delivered by Borrower to Bank fairly present in all material respects Borrower’s consolidated and consolidating (if any) financial condition as of the date thereof
and Borrower’s consolidated and consolidating (if any) results of operations for the period then ended. There has not been a material adverse change in the consolidated or in the consolidating (if any) financial condition of Borrower since the
date of the most recent of such financial statements submitted to Bank by Borrower. 

5.8      Solvency, Payment of Debts. Borrower is able to pay its debts (including trade debts) as
they mature; the fair saleable value of Borrower’s assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities; and Borrower is not left with unreasonably small capital after the transactions contemplated by
this Agreement. 
 5.9      Compliance with Laws and Regulations. Borrower and each Subsidiary
have met the minimum funding requirements of ERISA with respect to any employee benefit plans subject to ERISA. No event has occurred resulting from Borrower’s failure to comply with ERISA that is reasonably likely to result in Borrower’s
incurring any liability that could have a Material Adverse Effect. Borrower is not an “investment company” or a company “controlled” by an “investment company” within the meaning of the Investment Company Act of 1940.
Borrower is not engaged principally, or as one of its important activities, in the business of extending credit for the purpose of purchasing or carrying margin stock (within the meaning of Regulations T and U of the Board of Governors of the
Federal Reserve System). Borrower has not violated any statutes, laws, ordinances or rules applicable to it, the violation of which would reasonably be expected to have a Material Adverse Effect. Borrower and each Subsidiary have filed or caused to
be filed all tax returns required to be filed, and have paid, or have made adequate provision for the payment of, all taxes reflected therein except those being contested in good faith with adequate reserves under GAAP or where the failure to file
such returns or pay such taxes would not reasonably be expected to have a Material Adverse Effect. 

5.10      Subsidiaries. Borrower does not own any stock, partnership interest or other equity
securities of any Person, except for Permitted Investments. 

  
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 5.11      Government Consents. Borrower and each
Subsidiary have obtained all consents, approvals and authorizations of, made all declarations or filings with, and given all notices to, all governmental authorities that are necessary for the continued operation of Borrower’s business as
currently conducted, except where the failure to do so would not reasonably be expected to cause a Material Adverse Effect. 

5.12      Inbound Licenses. Except as disclosed on the Schedule, disclosed in accordance with
Section 6.9 or permitted pursuant to Section 7.5, Borrower is not a party to, nor is bound by, any material license or other similar agreement important for the conduct of Borrower’s business that prohibits or otherwise restricts
Borrower from granting a security interest in Borrower’s interest in such license or agreement or any other property important for the conduct of Borrower’s business, other than this Agreement or the other Loan Documents. 

 

	6.	 AFFIRMATIVE COVENANTS. 

Borrower covenants that, until payment in full of all outstanding Obligations (other than inchoate indemnification obligations), and for so
long as Bank may have any commitment to make a Credit Extension hereunder, Borrower shall do all of the following: 

6.1      Good Standing and Government Compliance. Borrower shall maintain its and (except as
permitted in Section 7.3) each of its Subsidiaries’ corporate existence and good standing in the respective states of formation, shall maintain qualification and good standing in each other jurisdiction in which the failure to so qualify
would reasonably be expected to have a Material Adverse Effect, and shall furnish to Bank the organizational identification number issued to Borrower by the authorities of the state in which Borrower is organized, if applicable. Borrower shall meet,
and shall cause each Subsidiary to meet, the minimum funding requirements of ERISA with respect to any employee benefit plans subject to ERISA. Borrower shall comply, and shall cause each Subsidiary to comply, with all statutes, laws, ordinances and
government rules and regulations to which it is subject, and shall maintain, and shall cause each of its Subsidiaries to maintain, in force all licenses, approvals and agreements, the loss of which or failure to comply with which would reasonably be
expected to have a Material Adverse Effect. 
 6.2      Financial Statements, Reports, Certificates.
Borrower shall deliver to Bank: (i) as soon as available, but in any event within 30 days after the end of each calendar month, a company prepared consolidated and consolidating (if any) balance sheet, income statement, and statement of
cash flows covering Borrower’s operations during such period, in a form reasonably acceptable to Bank and certified by a Responsible Officer; (ii) as soon as available, but in any event within 180 days after the end of Borrower’s
fiscal year, audited (or such other level as is required by the Investment Agreement) consolidated and consolidating (if any) financial statements of Borrower prepared in accordance with GAAP, consistently applied, together with (if required by the
Investment Agreement) an opinion which is either unqualified, qualified only for going concern so long as Borrower’s investors provide additional equity as needed or otherwise consented to in writing by Bank on such financial statements of an
independent certified public accounting firm reasonably acceptable to Bank; provided however for the 2015 fiscal year such financial statements may be company prepared and no audit will be required; (iii) annual budget approved by
Borrower’s Board of Directors as soon as available but in any event within 30 days after each fiscal year end during the term of this Agreement; (iv) if applicable, copies of all statements, reports and notices sent or made available
generally by Borrower to its security holders or to any holders of Subordinated Debt and all reports on Forms 10-K and 10-Q filed with the Securities and Exchange Commission; (v) promptly upon receipt of
notice thereof, a report of any legal actions pending or threatened in writing against Borrower or any Subsidiary that could reasonably be expected to result in damages or costs to Borrower or any Subsidiary of $250,000 or more; (vi) promptly
upon receipt, each management letter prepared by Borrower’s independent certified public accounting firm regarding Borrower’s management control systems; and (vii) such budgets, sales projections, operating plans, information relating to
clinical updates or other information as Bank may reasonably request from time to time. 

(a)      Within 30 days after the last day of each month, Borrower shall deliver to Bank with the monthly
financial statements a Compliance Certificate certified as of the last day of the applicable month and signed by a Responsible Officer in substantially the form of Exhibit D hereto. 

  
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 (b)      As soon as possible and in any event within 3
Business Days after becoming aware of the occurrence or existence of an Event of Default hereunder, a written statement of a Responsible Officer setting forth details of the Event of Default, and the action which Borrower has taken or proposes to
take with respect thereto. 
 (c)      Bank (through any of its officers, employees, or agents) shall
have the right, upon reasonable prior notice, from time to time during Borrower’s usual business hours but no more than once a year (unless an Event of Default has occurred and is continuing), to inspect Borrower’s Books and to make copies
thereof and to check, test, inspect, audit and appraise the Collateral at Borrower’s expense in order to verify Borrower’s financial condition or the amount of, condition of, or any other matter relating to, the Collateral. 

Borrower may deliver to Bank on an electronic basis any certificates, reports or information required pursuant to this Section 6.2, and
Bank shall be entitled to rely on the information contained in the electronic files, provided that Bank in good faith believes that the files were delivered by a Responsible Officer. Borrower shall include a submission date on any certificates and
reports to be delivered electronically. 
 6.3      Inventory and Equipment; Returns. Borrower
shall keep all finished goods Inventory and Equipment in good and merchantable condition (ordinary wear and tear excepted), free from all material defects except for Inventory and Equipment (i) sold in the ordinary course of business, and
(ii) for which adequate reserves have been made, in all cases in the United States and such other locations permitted under Section 7.11 or as to which Borrower gives prior written notice. Returns and allowances, if any, as between
Borrower and its account debtors shall be on the same basis and in accordance with the usual customary practices of Borrower. Borrower shall promptly notify Bank of all returns and recoveries and of all written disputes and claims involving
inventory having a book value of more than $100,000. 
 6.4      Taxes. Borrower shall make, and
cause each Subsidiary to make, due and timely payment or deposit of all material federal, state, and local taxes, assessments, or contributions required of it by law, including, but not limited to, those laws concerning income taxes, F.I.C.A.,
F.U.T.A. and state disability, and will execute and deliver to Bank, on demand, proof satisfactory to Bank indicating that Borrower or a Subsidiary has made such payments or deposits and any appropriate certificates attesting to the payment or
deposit thereof; provided that Borrower or a Subsidiary need not make any payment if the amount or validity of such payment is contested in good faith by appropriate proceedings and is reserved against (to the extent required by GAAP) by Borrower or
such Subsidiary. 
 6.5      Insurance. Borrower, at its expense, shall (i) keep the
Collateral insured against loss or damage, and (ii) maintain liability and other insurance, in each case in as ordinarily insured against by other owners in businesses similar to Borrower’s. All such policies of insurance shall be in such
form, with such companies, and in such amounts as reasonably satisfactory to Bank. All policies of property insurance shall contain a lender’s loss payable endorsement, in a form reasonably satisfactory to Bank, showing Bank as an additional
loss payee, and all liability insurance policies shall show Bank as an additional insured and specify that the insurer must give at least 10 days notice to Bank before canceling or refusing to renew its policy for any reason. Within 30 days of the
Closing Date, Borrower shall cause to be furnished to Bank a copy of its policies or certificates of insurance including any endorsements covering Bank or showing Bank as an additional insured. Upon Bank’s request, Borrower shall deliver to
Bank certified copies of the policies of insurance and evidence of all premium payments. Proceeds payable under any casualty policy will, at Borrower’s option, be payable to Borrower to repair or replace the property subject to the claim,
provided that any such repaired or replacement property shall be deemed Collateral in which Bank has been granted a first priority security interest (subject only to Permitted Liens), provided that if an Event of Default has occurred and is
continuing, all proceeds payable under any such policy shall, at Bank’s option, be payable to Bank to be applied on account of the Obligations. 

6.6      Primary Depository. Except as set forth below, within 30 days of the Closing Date
Borrower shall maintain all its depository and operating accounts with Bank and all its investment accounts with Bank or Bank’s affiliates; provided that prior to maintaining any investment accounts with Bank’s affiliates, Borrower, Bank,
and any such affiliate shall have entered into a securities account control agreement with respect to any such investment accounts, in form and substance satisfactory to Bank. Notwithstanding the above, Borrower shall be permitted to maintain
(i) payroll and employee benefits accounts at Bank or outside of Bank provided that if the same are outside of Bank, Borrower must deliver a control agreement in favor of Bank for such accounts, in form

  
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and substance satisfactory to Bank in its sole discretion, (ii) for a period of 90 days after the Closing Date, a deposit account at Silicon Valley Bank securing credit card reimbursement
obligations without the requirement for a control agreement provided that at no time shall such deposit account contain funds in excess of $10,000, and (iii) Cash in one or more accounts outside of Bank, without the requirement for control
agreements, provided that the total aggregate amount of Cash maintained in all accounts outside of Bank pursuant to this section (iv) does not exceed (x) $100,000 from the date that is 31 days after the Closing Date through the date that is 90
days after the Closing Date, (y) $50,000 from the date 91 days after the Closing Date through the date 180 days after the Closing Date, and (z) $20,000 at all times thereafter. The foregoing notwithstanding, at no time from the date that is 31 days
after the Closing Date and thereafter shall Borrower maintain cash outside of Bank in an aggregate amount in excess of $250,000. 

6.7      Intentionally Omitted. 

6.8      Intentionally Omitted. 

6.9      Consent of Inbound Licensors. Not more than 10 days after entering into or becoming bound
by any material inbound license or similar agreement for the use of intellectual property (for the avoidance of doubt, excluding licenses of open source, over the counter software, prepackaged software and other software that is commercially
available to the public), Borrower shall: (i) provide written notice to Bank of the material terms of such license or agreement with a description of its likely impact on Borrower’s business or financial condition; and (ii) upon
Bank’s request, in good faith use commercially reasonable efforts to obtain the consent of, or waiver by, any person whose consent or waiver is necessary for Borrower’s interest in such licenses or contract rights to be deemed Collateral
and for Bank to have a security interest in it that could reasonably be expected to otherwise be restricted by the terms of the applicable license or agreement, whether now existing or entered into in the future, provided, however, that the failure
to obtain any such consent or waiver shall not constitute a default under this Agreement. 

6.10      Creation/Acquisition of Subsidiaries. In the event any Borrower or any Subsidiary of any
Borrower creates or acquires any Subsidiary, Borrower or such Subsidiary shall promptly notify Bank of such creation or acquisition, and Borrower or such Subsidiary shall take all actions reasonably requested by Bank to achieve any of the following
with respect to such “New Subsidiary” (defined as a Subsidiary formed after the date hereof during the term of this Agreement): (i) if such New Subsidiary is organized under the laws of the United States, to cause New
Subsidiary to become either a co-Borrower hereunder, or a secured guarantor with respect to the Obligations; and (ii) to grant and pledge to Bank a perfected security interest in 100% of the stock, units
or other evidence of ownership held by Borrower or its Subsidiaries of any such New Subsidiary which is organized under the laws of the United States, and 65% of the stock, units or other evidence of ownership held by Borrower or its Subsidiaries of
any such New Subsidiary which is not organized under the laws of the United States. 

6.11      Further Assurances. At any time and from time to time Borrower shall execute and deliver
such further instruments and take such further action as may reasonably be requested by Bank to effect the purposes of this Agreement. 
  

	7.	 NEGATIVE COVENANTS. 

Borrower covenants and agrees that, so long as any credit hereunder shall be available and until the outstanding Obligations (other than
inchoate indemnification obligations) are paid in full or for so long as Bank may have any commitment to make any Credit Extensions, Borrower will not do any of the following without Bank’s prior written consent, which shall not be unreasonably
withheld: 
 7.1      Dispositions. Convey, sell, lease, license, transfer or otherwise dispose
of (collectively, to “Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of its business or property, or move cash balances on deposit with Bank to accounts opened at another financial institution, other than as
permitted under Section 6.6, Permitted Transfers or Permitted Investments. 

  
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 7.2      Change in Name, Location, Executive Office,
or Executive Management; Change in Business; Change in Fiscal Year; Change in Control. Change its name or the state of Borrower’s formation or relocate its chief executive office without 30 days prior written notification to Bank; replace
or suffer the departure of its chief executive officer or chief financial officer, if any, without delivering written notification to Bank within 10 Business Days; suffer a change on its board of directors which results in the failure of at least
one representative of Flagship Ventures Management, Inc. or its Affiliates to serve as a voting member, or suffer the resignation of one or more directors from its board of directors in anticipation of the Borrower’s insolvency, in either case
without the prior written consent of Bank which may be withheld in Bank’s sole discretion; take action to liquidate, wind up, or otherwise cease to conduct business in the ordinary course; engage in any business, or permit any of its
Subsidiaries to engage in any business, other than or reasonably related or incidental to the businesses currently engaged in by Borrower; change its fiscal year end; have a Change in Control. 

7.3      Mergers or Acquisitions. Merge or consolidate, or permit any of its Subsidiaries to merge
or consolidate, with or into any other business organization (other than mergers or consolidations of a Subsidiary into another Subsidiary or into Borrower), or acquire, or permit any of its Subsidiaries to acquire, all or substantially all of the
capital stock or property of another Person (other than Permitted Investments) except where (a) each of the following conditions is applicable: (i) the consideration paid in connection with such transactions (including assumption of
liabilities) does not in the aggregate exceed $250,000 during any fiscal year, (ii) no Event of Default has occurred, is continuing or would exist after giving effect to such transactions, (iii) such transactions do not result in a Change
in Control, and (iv) Borrower is the surviving entity; or (b) the Obligations are repaid in full concurrently with the closing of any merger or consolidation of Borrower in which Borrower is not the surviving entity; provided, however,
that Borrower shall not, without Bank’s prior written consent, enter into any binding contractual arrangement with any Person to attempt to facilitate a merger or acquisition of Borrower, unless (i) no Event of Default exists when such
agreement is entered into by Borrower, (ii) such agreement does not give such Person the right to claim any fee, payment or damages from any parties, other than from Borrower or Borrower’s investors, in connection with a sale of
Borrower’s stock or assets pursuant to or resulting from an assignment for the benefit of creditors, an asset turnover to Borrower’s creditors (including, without limitation, Bank), foreclosure, bankruptcy or similar liquidation, and
(iii) Borrower notifies Bank in advance of entering into such an agreement (provided that the failure to give such notification shall not be deemed a breach of this Agreement). 

7.4      Indebtedness. Create, incur, assume, guarantee or be or remain liable with respect to any
Indebtedness, or permit any Subsidiary so to do, other than Permitted Indebtedness, or prepay any Indebtedness or take any actions which impose on Borrower an obligation to prepay any Indebtedness, except Indebtedness to Bank. 

7.5      Encumbrances. Create, incur, assume or allow any Lien with respect to its property, or
assign or otherwise convey any right to receive income, including the sale of any Accounts, or permit any of its Subsidiaries so to do, except for Permitted Liens, or covenant to any other Person (other than (i) the licensors of in-licensed property with respect to such property, (ii) the lessors of specific equipment or lenders financing specific equipment with respect to such leased or financed equipment or (iii) as disclosed on
the Schedule) that Borrower in the future will refrain from creating, incurring, assuming or allowing any Lien with respect to any of Borrower’s property, except for licenses and agreements containing customary anti-assignment provisions so
long as such provisions are, or would be, rendered unenforceable or ineffective under applicable law (including, without limitation Sections 94-06, 9-407 and 9-408 of
the Code). 
 7.6      Distributions. Pay any dividends or make any other distribution or
payment on account of or in redemption, retirement or purchase of any of its capital stock, except that Borrower may (i) repurchase the stock of former employees or directors pursuant to stock repurchase agreements in an aggregate amount not to
exceed $150,000 in any fiscal year, so long as an Event of Default does not exist prior to such repurchase or would not exist after giving effect to such repurchase, and (ii) repurchase the stock of former employees or directors pursuant to
stock repurchase agreements in any amount where the consideration for the repurchase is the cancellation of indebtedness owed by such former employees or directors to Borrower regardless of whether an Event of Default exists. 

7.7      Investments. Directly or indirectly acquire or own an Investment in, or make any
Investment in or to any Person, or permit any of its Subsidiaries so to do, other than Permitted Investments, or except as permitted under Section 6.6, maintain or invest any of its investment property with a Person other than Bank or permit
any 

  
 9 

 
Subsidiary to do so unless such Person has entered into a control agreement with Bank, in form and substance reasonably satisfactory to Bank, or suffer or permit any Subsidiary to be a party to,
or be bound by, an agreement that restricts such Subsidiary from paying dividends or otherwise distributing property to Borrower. 

7.8      Capitalized Expenditures. Make Capitalized Expenditures in excess of $250,000 in the
aggregate in any fiscal year of Borrower. 
 7.9      Transactions with Affiliates. Directly or
indirectly enter into or permit to exist any material transaction with any Affiliate of Borrower except for transactions that are in the ordinary course of Borrower’s business, upon fair and reasonable terms that are no less favorable to
Borrower than would be obtained in an arm’s length transaction with a non-affiliated Person and except for transactions permitted under Sections 7.2, 7.3, 7.4, 7.7 or 7.9. 

7.10      Subordinated Debt. Make any payment in respect of any Subordinated Debt, or permit any
of its Subsidiaries to make any such payment, except in compliance with the terms of such Subordinated Debt, or amend any provision affecting Bank’s rights contained in any documentation relating to the Subordinated Debt without Bank’s
prior written consent. 
 7.11      Inventory and Equipment. Store the Inventory or the
Equipment of a book value in excess of $250,000 with a bailee, warehouseman, collocation facility or similar third party unless the third party has been notified of Bank’s security interest and Bank (a) has received an acknowledgment from
the third party that it is holding or will hold the Inventory or Equipment for Bank’s benefit or (b) is in possession of the warehouse receipt, where negotiable, covering such Inventory or Equipment. Except for Inventory sold in the
ordinary course of business and for movable items of personal property having an aggregate book value not in excess of $250,000, and except for such other locations as Bank may approve in writing, Borrower shall keep the Inventory and Equipment only
at the location set forth in Section 10 of the Schedule, and such other locations of which Borrower gives Bank prior written notice and as to which Bank is able to take such actions as may be reasonably necessary to perfect its security
interest or to obtain a bailee’s acknowledgment of Bank’s rights in the Collateral. 

7.12      No Investment Company; Margin Regulation. Become or be controlled by an “investment
company,” within the meaning of the Investment Company Act of 1940, or become principally engaged in, or undertake as one of its important activities, the business of extending credit for the purpose of purchasing or carrying margin stock, or
use the proceeds of any Credit Extension for such purpose. 
  

	8.	 EVENTS OF DEFAULT. 

Any one or more of the following events shall constitute an Event of Default by Borrower under this Agreement: 

8.1      Payment Default. If Borrower fails to (a) make any payment of principal or interest
on any Credit Extension when due or (b) pay any other Obligations within three (3) Business Days after such Obligations are due and payable. During the cure period, the failure to make or pay any payment specified under clause
(B) hereunder is not an Event of Default (but no Credit Extension will be made during the cure period); 

8.2      Covenant Default. 

(a)      If Borrower fails to perform any obligation under Sections 6.2 (financial reporting), 6.4
(taxes), 6.5 (insurance) or 6.6 (primary accounts), or violates any of the covenants contained in Article 7 of this Agreement; or 

(b)      If Borrower fails or neglects to perform or observe any other material term, provision,
condition or covenant contained in this Agreement, in any of the Loan Documents, or in any other present or future agreement between Borrower and Bank and as to any default under such other term, provision, condition or covenant that can be cured,
has failed to cure such default within 10 days after Borrower receives notice thereof or any officer of Borrower becomes aware thereof; provided, however, that if the default cannot by its nature be cured

  
 10 

 
within the 10 day period or cannot after diligent attempts by Borrower be cured within such 10 day period, and such default is likely to be cured within a reasonable time, then Borrower shall
have an additional reasonable period (which shall not in any case exceed 30 days) to attempt to cure such default, and within such reasonable time period the failure to have cured such default shall not be deemed an Event of Default but no Credit
Extensions will be made; 
 8.3      Material Adverse Change. If there occurs any circumstance
or any circumstances which would reasonably be expected to have a Material Adverse Effect; 

8.4      Attachment. If any material portion of Borrower’s assets is attached, seized,
subjected to a writ or distress warrant, or is levied upon, or comes into the possession of any trustee, receiver or person acting in a similar capacity and such attachment, seizure, writ or distress warrant or levy has not been removed, discharged
or rescinded within 10 days, or if Borrower is enjoined, restrained, or in any way prevented by court order from continuing to conduct all or any material part of its business affairs, or if a judgment or other claim becomes a lien or encumbrance
upon any material portion of Borrower’s assets, or if a notice of lien, levy, or assessment is filed of record with respect to any material portion of Borrower’s assets by the United States Government, or any department, agency, or
instrumentality thereof, or by any state, county, municipal, or governmental agency, and the same is not paid within ten days after Borrower receives notice thereof, provided that none of the foregoing shall constitute an Event of Default where such
action or event is stayed or an adequate bond has been posted pending a good faith contest by Borrower (provided that no Credit Extensions will be made during such cure period); 

8.5      Insolvency. If Borrower becomes insolvent, or if an Insolvency Proceeding is commenced by
Borrower, or if an Insolvency Proceeding is commenced against Borrower and is not dismissed or stayed within 45 days (provided that no Credit Extensions will be made prior to the dismissal of such Insolvency Proceeding); 

8.6      Other Agreements. If there is a default or other failure to perform in any agreement to
which Borrower is a party with a third party or parties (a) resulting in a right by such third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in an amount in excess of $250,000, (b) in connection with
any lease of real property that has not been cured or waived by the landlord under such lease (but only if the landlord thereof has given Borrower notice of such default), or (c) that would reasonably be expected to have a Material Adverse
Effect; 
 8.7      Judgments. If a final,
non-appealable, uninsured judgment or judgments for the payment of money in an amount, individually or in the aggregate, of at least $250,000 shall be rendered against Borrower and shall remain unsatisfied and
unstayed for a period of 10 days (provided that no Credit Extensions will be made prior to the satisfaction or stay of the judgment); or 

8.8      Misrepresentations. If any material misrepresentation or material misstatement exists now
or hereafter in any warranty or representation set forth herein or in any certificate delivered to Bank by any Responsible Officer pursuant to this Agreement or to induce Bank to enter into this Agreement or any other Loan Document. 

8.9      Guaranty. If any guaranty of all or a portion of the Obligations (a “Guaranty”)
ceases for any reason to be in full force and effect, or any guarantor fails to perform any obligation under any Guaranty or a security agreement securing any Guaranty (collectively, the “Guaranty Documents”), or any event of default
occurs under any Guaranty Document or any guarantor revokes or purports to revoke a Guaranty, or any material misrepresentation or material misstatement exists now or hereafter in any warranty or representation set forth in any Guaranty Document or
in any certificate delivered to Bank in connection with any Guaranty Document, or if any of the circumstances described in Sections 8.3 through 8.9 occur with respect to any guarantor. 

  
 11 

	9.	 BANK’S RIGHTS AND REMEDIES. 

9.1      Rights and Remedies. Upon the occurrence and during the continuance of an Event of
Default, Bank may, at its election, without notice of its election and without demand, do any one or more of the following, all of which are authorized by Borrower: 

(a)      Declare all Obligations, whether evidenced by this Agreement, by any of the other Loan
Documents, or otherwise, immediately due and payable (provided that upon the occurrence of an Event of Default described in Section 8.5 (insolvency), all Obligations shall become immediately due and payable without any action by Bank); 

(b)      Demand that Borrower (i) deposit cash with Bank in an amount equal to the amount of any
Letters of Credit remaining undrawn, as collateral security for the repayment of any future drawings under such Letters of Credit, and (ii) pay in advance all Letter of Credit fees scheduled to be paid or payable over the remaining term of the
Letters of Credit, and Borrower shall promptly deposit and pay such amounts; 
 (c)      Cease
advancing money or extending credit to or for the benefit of Borrower under this Agreement or under any other agreement between Borrower and Bank; 

(d)      Settle or adjust disputes and claims directly with account debtors for amounts, upon terms and
in whatever order that Bank reasonably considers advisable; 
 (e)      Make such payments and do such
acts as Bank considers necessary or reasonable to protect its security interest in the Collateral. Borrower agrees to assemble the Collateral if Bank so requires, and to make the Collateral available to Bank as Bank may designate. Borrower
authorizes Bank to enter the premises where the Collateral is located, to take and maintain possession of the Collateral, or any part of it, and to pay, purchase, contest, or compromise any encumbrance, charge, or lien which in Bank’s
determination appears to be prior or superior to its security interest and to pay all expenses incurred in connection therewith. With respect to any of Borrower’s owned premises, Borrower hereby grants Bank a license to enter into possession of
such premises and to occupy the same, without charge, in order to exercise any of Bank’s rights or remedies provided herein, at law, in equity, or otherwise; 

(f)      place a “hold” on any account maintained with Bank and/or deliver a notice of
exclusive control, any entitlement order, or other directions or instructions pursuant to any control agreement or similar agreements providing control of any Collateral; 

(g)      Set off and apply to the Obligations then due any and all (i) balances and deposits of
Borrower held by Bank, and (ii) indebtedness at any time owing to or for the credit or the account of Borrower held by Bank; 

(h)      Ship, reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise for sale,
and sell (in the manner provided for herein) the Collateral. Bank is hereby granted a license or other right, solely pursuant to the provisions of this Section 9.1, to use, without charge, Borrower’s labels, patents, copyrights, rights of
use of any name, trade secrets, trade names, trademarks, service marks, and advertising matter, or any property of a similar nature, as it pertains to the Collateral, in completing production of, advertising for sale, and selling any Collateral and,
in connection with Bank’s exercise of its rights under this Section 9.1, Borrower’s rights under all licenses and all franchise agreements shall inure to Bank’s benefit; 

(i)      Sell the Collateral at either a public or private sale, or both, by way of one or more contracts
or transactions, for cash or on terms, in such manner and at such places (including Borrower’s premises) as Bank determines is commercially reasonable, and apply any proceeds to the Obligations in whatever manner or order Bank deems
appropriate. Bank may sell the Collateral without giving any warranties as to the Collateral, Bank may specifically disclaim any warranties of title or the like. This procedure will not be considered adversely to affect the commercial reasonableness
of any sale of the Collateral. If Bank sells any of the Collateral upon credit, Borrower will be credited only with payments actually made by the purchaser, received by Bank, and applied to the indebtedness of the purchaser. If the purchaser fails
to pay for the Collateral, Bank may resell the Collateral and Borrower shall be credited with the proceeds of the sale; 

(j)      Bank may credit bid and purchase at any public sale; 

  
 12 

 (k)      Apply for the appointment of a receiver,
trustee, liquidator or conservator of the Collateral, without notice and without regard to the adequacy of the security for the Obligations and without regard to the solvency of Borrower, any guarantor or any other Person liable for any of the
Obligations; and 
 (l)      Any deficiency that exists after disposition of the Collateral as provided
above will be paid immediately by Borrower. 
 Bank may comply with any applicable state or federal law requirements in connection with a disposition of the
Collateral and compliance will not be considered adversely to affect the commercial reasonableness of any sale of the Collateral. 

9.2      Power of Attorney. Effective only upon the occurrence and during the continuance of an
Event of Default, Borrower hereby irrevocably appoints Bank (and any of Bank’s designated officers, or employees) as Borrower’s true and lawful attorney to: (a) send requests for verification of Accounts or notify account debtors of
Bank’s security interest in the Accounts; (b) endorse Borrower’s name on any checks or other forms of payment or security that may come into Bank’s possession; (c) sign Borrower’s name on any invoice or bill of lading
relating to any Account, drafts against account debtors, schedules and assignments of Accounts, verifications of Accounts, and notices to account debtors; (d) dispose of any Collateral; (e) make, settle, and adjust all claims under and
decisions with respect to Borrower’s policies of insurance; (f) settle and adjust disputes and claims respecting the accounts directly with account debtors, for amounts and upon terms which Bank determines to be reasonable; and
(g) file, in its sole discretion, one or more financing or continuation statements and amendments thereto, relative to any of the Collateral; provided Bank may exercise such power of attorney to sign the name of Borrower on any of the documents
described in clause (g) above, regardless of whether an Event of Default has occurred. The appointment of Bank as Borrower’s attorney in fact, and each and every one of Bank’s rights and powers, being coupled with an interest, is
irrevocable until all of the Obligations (other than inchoate indemnification obligations) have been fully repaid and performed and Bank’s obligation to provide advances hereunder is terminated. 

9.3      Accounts Collection. At any time after the occurrence and during the continuation of an
Event of Default, Bank may notify any Person owing funds to Borrower of Bank’s security interest in such funds and verify the amount of such Account. Borrower shall collect all amounts owing to Borrower for Bank, receive in trust all payments
as Bank’s trustee, and immediately deliver such payments to Bank in their original form as received from the account debtor, with proper endorsements for deposit. 

9.4      Bank Expenses. If Borrower fails to pay any amounts or furnish any required proof of
payment due to third persons or entities, as required under the terms of this Agreement, then Bank may do any or all of the following after reasonable notice to Borrower: (a) make payment of the same or any part thereof; or (b) obtain and
maintain insurance policies of the type discussed in Section 6.5 of this Agreement, and take any action with respect to such policies as Bank deems prudent. Any amounts so paid or deposited by Bank shall constitute Bank Expenses, shall be
immediately due and payable, and shall bear interest at the then applicable rate hereinabove provided, and shall be secured by the Collateral. Any payments made by Bank shall not constitute an agreement by Bank to make similar payments in the future
or a waiver by Bank of any Event of Default under this Agreement. 
 9.5      Bank’s Liability
for Collateral. Bank has no obligation to clean up or otherwise prepare the Collateral for sale. All risk of loss, damage or destruction of the Collateral shall be borne by Borrower. 

9.6      No Obligation to Pursue Others. Bank has no obligation to attempt to satisfy the
Obligations by collecting them from any other person liable for them and Bank may release, modify or waive any collateral provided by any other Person to secure any of the Obligations, all without affecting Bank’s rights against Borrower.
Borrower waives any right it may have to require Bank to pursue any other Person for any of the Obligations. 

9.7      Remedies Cumulative. Bank’s rights and remedies under this Agreement, the Loan
Documents, and all other agreements shall be cumulative. Bank shall have all other rights and remedies not inconsistent herewith as provided under the Code, by law, or in equity. No exercise by Bank of one right or remedy shall be deemed an
election, and no waiver by Bank of any Event of Default on Borrower’s part shall be deemed a continuing waiver. No delay by Bank shall constitute a waiver, election, or acquiescence by it. No waiver by Bank shall be effective unless made in a
written document signed on behalf of Bank and then shall be effective only in the specific instance and for the specific purpose for which it was given. Borrower expressly agrees that this Section 9.7 may not be waived or modified by Bank by
course of performance, conduct, estoppel or otherwise. 

  
 13 

 9.8      Demand; Protest. Except as otherwise
provided in this Agreement, Borrower waives demand, protest, notice of protest, notice of default or dishonor, notice of payment and nonpayment and any other notices relating to the Obligations. 

 

	10.	 NOTICES. 

Unless otherwise provided in this Agreement, all notices or demands by any party relating to this Agreement or any other agreement entered into
in connection herewith shall be in writing and (except for financial statements and other informational documents which may be sent by first-class mail, postage prepaid) shall be personally delivered or sent by a recognized overnight delivery
service, certified mail, postage prepaid, return receipt requested, or by telefacsimile to Borrower or to Bank, as the case may be, at its addresses set forth below: 
  

			
	If to Borrower:	    	 KALEIDO BIOSCIENCES, INC.
 Attn: Chief Financial
Officer
 47 Moulton Street
 Cambridge, MA 02138

		
	If to Bank:	    	 PACIFIC WESTERN BANK
 406 Blackwell Street,
Suite 240
 Durham, North Carolina 27701
 Attn: Loan Operations
Manager
 FAX: (919) 314-3080

		
	with a copy to:	    	 PACIFIC WESTERN BANK
 131 Oliver Street, 2nd
Floor
 Boston, MA 02110
 Attn: Scott Hansen

FAX: (781) 547-0848

 The parties hereto may change the address at which they are to receive notices hereunder, by notice in writing
in the foregoing manner given to the other. 
  

	11.	 CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER. 

This Agreement shall be governed by, and construed in accordance with, the internal laws of the State of North Carolina, without regard to principles of
conflicts of law. Jurisdiction shall lie in the State of North Carolina. All disputes, controversies, claims, actions and similar proceedings arising with respect to Borrower’s account or any related agreement or transaction shall be brought in
the General Court of Justice of North Carolina sitting in Durham County, North Carolina or the United States District Court for the Middle District of North Carolina, except as provided below with respect to arbitration of such matters. BANK AND
BORROWER EACH ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED. EACH OF THEM, AFTER CONSULTING OR HAVING HAD THE OPPORTUNITY TO CONSULT, WITH COUNSEL OF THEIR CHOICE, KNOWINGLY, VOLUNTARILY AND
INTENTIONALLY WAIVES ANY RIGHT ANY OF THEM MAY HAVE TO A TRIAL BY JURY IN ANY LITIGATION BASED UPON OR ARISING OUT OF THIS AGREEMENT OR ANY RELATED INSTRUMENT OR LOAN DOCUMENT OR ANY OF THE TRANSACTIONS CONTEMPLATED BY THIS AGREEMENT OR ANY COURSE
OF CONDUCT, DEALING, STATEMENTS (WHETHER ORAL OR WRITTEN), OR ACTION OF ANY OF THEM. THESE PROVISIONS SHALL NOT BE DEEMED TO HAVE BEEN MODIFIED IN ANY RESPECT OR RELINQUISHED BY BANK OR BORROWER, EXCEPT BY A WRITTEN INSTRUMENT EXECUTED BY EACH OF
THEM. If the jury waiver set forth in this Section 11 is not enforceable, then any dispute, controversy, claim, action or similar proceeding arising out of or relating to this Agreement, the Loan Documents or any of the transactions
contemplated therein shall be settled by final and binding arbitration held in Durham County, North Carolina in accordance with the then current Commercial Arbitration Rules of the American Arbitration Association

  
 14 

 
by one arbitrator appointed in accordance with those rules. The arbitrator shall apply North Carolina law to the resolution of any dispute, without reference to rules of conflicts of law or rules
of statutory arbitration. Judgment upon any award resulting from arbitration may be entered into and enforced by any state or federal court having jurisdiction thereof. Notwithstanding the foregoing, the parties may apply to any court of competent
jurisdiction for preliminary or interim equitable relief, or to compel arbitration in accordance with this Section. The costs and expenses of the arbitration, including without limitation, the arbitrator’s fees and expert witness fees, and
reasonable attorneys’ fees, incurred by the parties to the arbitration may be awarded to the prevailing party, in the discretion of the arbitrator, or may be apportioned between the parties in any manner deemed appropriate by the arbitrator.
Unless and until the arbitrator decides that one party is to pay for all (or a share) of such costs and expenses, both parties shall share equally in the payment of the arbitrator’s fees as and when billed by the arbitrator. 

 

	12.	 GENERAL PROVISIONS. 

12.1      Successors and Assigns. This Agreement shall bind and inure to the benefit of the
respective successors and permitted assigns of each of the parties and shall bind all persons who become bound as a debtor to this Agreement; provided, however, that neither this Agreement nor any rights hereunder may be assigned by Borrower without
Bank’s prior written consent, which consent may be granted or withheld in Bank’s sole discretion. Bank shall have the right without the consent of or notice to Borrower to sell, assign, transfer, negotiate, or grant participation in all or
any part of, or any interest in, Bank’s obligations, rights and benefits hereunder. 

12.2      Indemnification. Borrower shall defend, indemnify and hold harmless Bank and its
officers, employees, and agents against: (a) all obligations, demands, claims, and liabilities claimed or asserted by any other party in connection with the transactions contemplated by this Agreement; and (b) all losses or Bank Expenses
in any way suffered, incurred, or paid by Bank, its officers, employees and agents as a result of or in any way arising out of, following, or consequential to transactions between Bank and Borrower whether under this Agreement, or otherwise
(including without limitation reasonable attorneys fees and expenses), except for losses caused by Bank’s gross negligence or willful misconduct. 

12.3      Time of Essence. Time is of the essence for the performance of all obligations set forth
in this Agreement. 
 12.4      Severability of Provisions. Each provision of this Agreement
shall be severable from every other provision of this Agreement for the purpose of determining the legal enforceability of any specific provision. 

12.5      Amendments in Writing, Integration. All amendments to or terminations of this Agreement
or the other Loan Documents must be in writing, All prior agreements, understandings, representations, warranties, and negotiations between the parties hereto with respect to the subject matter of this Agreement and the other Loan Documents, if any,
are merged into this Agreement and the Loan Documents. 
 12.6      Counterparts. This Agreement
may be executed in any number of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, shall be deemed to be an original, and all of which, when taken together, shall constitute but one and the
same Agreement. Executed copies of the signature pages of this Agreement sent by facsimile or transmitted electronically in Portable Document Format (“PDF”), or any similar format, shall be treated as originals, fully binding and with full
legal force and effect, and the parties waive any rights they may have to object to such treatment. 

12.7      Survival. All covenants, representations and warranties made in this Agreement shall
continue in full force and effect so long as any Obligations remain outstanding or Bank has any obligation to make any Credit Extension to Borrower. The obligations of Borrower to indemnify Bank with respect to the expenses, damages, losses, costs
and liabilities described in Section 12.2 shall survive until all applicable statute of limitations periods with respect to actions that may be brought against Bank have run. 

12.8      Confidentiality. In handling any confidential information, Bank and Borrower and all
employees and agents of each such party shall exercise the same degree of care that such party exercises with respect to its own proprietary information of the same types to maintain the confidentiality of any
non-public information thereby 

  
 15 

 
received or received pursuant to this Agreement and the Loan Documents or upon request of Bank or its Affiliates, except that disclosure of such information may be made (i) in the case of
Bank, to the subsidiaries or Affiliates of Bank or Borrower in connection with their present or prospective business relations with Borrower (provided that such subsidiaries or Affiliates are bound by confidentiality obligations substantially the
same as those of this Section 12.8, (ii) in the case of Bank, to prospective transferees or purchasers of any interest in the Credit Extensions, provided that they have entered into a comparable confidentiality agreement in favor of Borrower
and have delivered a copy to Borrower, (iii) as required by law, regulations, rule or order, subpoena, judicial order or similar order, (iv) in the case of Bank, as may be required in connection with the examination, audit or similar
investigation of Bank and (v) as Bank may determine in connection with the enforcement of any remedies hereunder. Confidential information hereunder shall not include information that either: (a) is in the public domain or in the knowledge
or possession of the receiving party when disclosed to such party, or becomes part of the public domain after disclosure to such receiving party through no fault of such receiving party; or (b) is disclosed to such receiving party by a third
party, provided the receiving party does not have actual knowledge that such third party is prohibited from disclosing such information. 

  
 16 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the date first above
written. 
  

			
	KALEIDO BIOSCIENCES, INC.
		
	By:	 	 /s/ Geoffrey von Maltzahn

	Name:	 	Geoffrey von Maltzahn
	Title:	 	President
	
	PACIFIC WESTERN BANK
		
	By:	 	  

	Name:	 	  

	Title:	 	  

 [Signature Page to Loan and Security Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the date first above
written. 
  

			
	KALEIDO BIOSCIENCES, INC.
		
	By:	 	  

	Name:	 	  

	Title:	 	  

	
	PACIFIC WESTERN BANK
		
	By:	 	 /s/ Scott Hansen

	Name:	 	Scott Hansen
	Title:	 	Vice President

 [Signature Page to Loan and Security Agreement] 

 EXHIBIT A 

DEFINITIONS 
 “Accounts” means all presently
existing and hereafter arising accounts, contract rights, payment intangibles and all other forms of obligations owing to Borrower arising out of the sale or lease of goods (including, without limitation, the licensing of software and other
technology) or the rendering of services by Borrower and any and all credit insurance, guaranties, and other security therefor, as well as all merchandise returned to or reclaimed by Borrower and Borrower’s Books relating to any of the
foregoing. 
 “Affiliate” means, with respect to any Person, any Person that owns or controls directly or indirectly such Person, any Person that
controls or is controlled by or is under common control with such Person, and each of such Person’s senior executive officers, directors, and general partners. 

“Authorized Officer” means someone designated as such in the corporate resolution provided by Borrower to Bank including any such resolutions in
which this Agreement and the transactions contemplated hereunder are authorized by Borrower’s board of directors. If Borrower provides subsequent corporate resolutions to Bank after the Closing Date, the individual(s) designated as
“Authorized Officer(s)” in the most-recently provided resolution shall be the only “Authorized Officers” for purposes of this Agreement. 

“Availability End Date” means December 21, 2016. 

“Bank Expenses” means all reasonable costs or expenses (including reasonable attorneys’ fees and expenses, whether generated in-house or by outside counsel) incurred in connection with the preparation, negotiation, administration, and enforcement of the Loan Documents; reasonable Collateral audit fees; and Bank’s reasonable
attorneys’ fees and expenses (whether generated in-house or by outside counsel) incurred in amending, enforcing or defending the Loan Documents (including fees and expenses of appeal), incurred before,
during and after an Insolvency Proceeding, whether or not suit is brought. 
 “Borrower’s Books” means all of Borrower’s books and
records including: ledgers; records concerning Borrower’s assets or liabilities, the Collateral, business operations or financial condition; and all computer programs, or tape files, and the equipment, containing such information. 

“Business Day” means any day that is not a Saturday, Sunday, or other day on which banks in the State of North Carolina are authorized or required
to close. 
 “Capitalized Expenditures” means current period unfinanced cash expenditures that are capitalized and amortized over a period of time
in accordance with GAAP, including but not limited to capitalized cash expenditures for capital equipment, capitalized manufacturing and labor costs as they relate to inventory, and software development. 

“Cash” means unrestricted cash and cash equivalents. 

“Change in Control” shall mean a transaction other than a bona fide equity financing or scries of financings on terms and from investors reasonably
acceptable to Flagship Ventures Management Inc. or its affiliates in which any “person” or “group” (within the meaning of Section 13(d) and 14(d)(2) of the Securities Exchange Act of 1934) becomes the “beneficial
owner” (as defined in Rule 13d-3 under the Securities Exchange Act of 1934), directly or indirectly, of a sufficient number of shares of all classes of stock then outstanding of Borrower ordinarily
entitled to vote in the election of directors, empowering such “person” or “group” to elect a majority of the Board of Directors of Borrower, who did not have such power before such transaction. 

“Closing Date” means the date of this Agreement. 

“Code” means the North Carolina Uniform Commercial Code as amended or supplemented from time to time. 

  
 1 

 “Collateral” means the property described on Exhibit B attached hereto and all Negotiable
Collateral to the extent not described on Exhibit B, except to the extent (i) any such property is nonassignable by its terms without the consent of the licensor thereof or another party (but only to the extent such prohibition on transfer is
enforceable under applicable law, including, without limitation, §25-9-406 and
§25-9-408 of the Code), (ii) the granting of a security interest therein is contrary to applicable law, provided that upon the cessation of any such restriction or
prohibition, such property shall automatically become part of the Collateral, (iii) any such property constitutes the capital stock of a controlled foreign corporation (as defined in the IRC), in excess of 65% of the voting power of all classes
of capital stock of such controlled foreign corporations entitled to vote, (iv) any such property (including any attachments, accessions or replacements) is subject to a Lien that is permitted pursuant to clauses (c) or (e) of the
definition of Permitted Liens, if the grant of a security interest with respect to such property pursuant to this Agreement would be prohibited by the agreement creating such Permitted Lien or would otherwise constitute a default thereunder,
provided, that such property will be deemed “Collateral” hereunder upon the termination and release of such Permitted Lien or (v) any such property is Intellectual Property, in any medium, of any kind or nature whatsoever, now or
hereafter owned or acquired or received by Borrower, or in which Borrower now holds or hereafter acquires or receives any right or interest; provided, however, that the Collateral shall include all accounts and general intangibles that consist of
rights to payment and proceeds from the sale, licensing or disposition of all or any part, or rights in, the foregoing (the “Rights to Payment”). Notwithstanding the foregoing, if a judicial authority (including a U.S. Bankruptcy Court)
holds that a security interest in the underlying Intellectual Property is necessary to have a security interest in the Rights to Payment, then the Collateral shall automatically, and effective as of December 21, 2015, include the Intellectual
Property to the extent and only to the extent necessary to permit perfection of Bank’s security interest in the Rights to Payment, and further provided, however, that Bank’s enforcement rights with respect to any security interest in the
Intellectual Property shall be absolutely limited to the Rights to Payment only, and Bank shall have no recourse whatsoever with respect to the underlying Intellectual Property. 

“Collateral State” means the state or states where the Collateral is located, which is Massachusetts. 

“Compliance Certificate” means a compliance certificate, in substantially the form of Exhibit D attached hereto, executed by a Responsible Officer
of the Borrower. 
 “Contingent Obligation” means, as applied to any Person, any direct or indirect liability, contingent or otherwise, of that
Person with respect to (i) any indebtedness, lease, dividend, letter of credit or other obligation of another, including, without limitation, any such obligation directly or indirectly guaranteed, endorsed,
co-made or discounted or sold with recourse by that Person, or in respect of which that Person is otherwise directly or indirectly liable; (ii) any obligations with respect to undrawn letters of credit,
corporate credit cards or merchant services issued for the account of that Person; and (iii) all obligations arising under any interest rate, currency or commodity swap agreement, interest rate cap agreement, interest rate collar agreement, or
other agreement or arrangement designated to protect a Person against fluctuation in interest rates, currency exchange rates or commodity prices; provided, however, that the term “Contingent Obligation” shall not include endorsements for
collection or deposit in the ordinary course of business. The amount of any Contingent Obligation shall be deemed to be an amount equal to the stated or determined amount of the primary obligation in respect of which such Contingent Obligation is
made or, if not stated or determinable, the maximum reasonably anticipated liability in respect thereof as determined by such Person in good faith; provided, however, that such amount shall not in any event exceed the maximum amount of the
obligations under the guarantee or other support arrangement. 
 “Copyrights” means any and all copyright rights, copyright applications,
copyright registrations and like protections in each work or authorship and derivative work thereof, whether published or unpublished and whether or not the same also constitutes a trade secret, now or hereafter existing, created, acquired or held.

 “Credit Extension” means each Term Loan, or any other extension of credit by Bank, to or for the benefit of Borrower hereunder. 

“Equipment” means all present and future machinery, equipment, tenant improvements, furniture, fixtures, vehicles, tools, parts and attachments in
which Borrower has any interest. 

  
 2 

 “ERISA” means the Employee Retirement Income Security Act of 1974, as amended, and the regulations
thereunder. 
 “Event of Default” has the meaning assigned in Article 8. 

“GAAP” means generally accepted accounting principles, consistently applied, as in effect from time to time in the United States. 

“Indebtedness” means (a) all indebtedness for borrowed money or the deferred purchase price of property or services, including without
limitation reimbursement and other obligations with respect to surety bonds and letters of credit, (b) all obligations evidenced by notes, bonds, debentures or similar instruments, (c) all capital lease obligations, and (d) all
Contingent Obligations, including but not limited to any sublimit contained herein. 
 “Insolvency Proceeding” means any proceeding commenced by
or against any Person or entity under any provision of the United States Bankruptcy Code, as amended, or under any other bankruptcy or insolvency law, including assignments for the benefit of creditors, formal or informal moratoria, compositions,
extension generally with its creditors, or proceedings seeking reorganization, arrangement, or other relief. 
 “Intellectual Property” means all
of Borrower’s right, title, and interest in and to the following: 
 (a)      Copyrights,
Trademarks and Patents; 
 (b)      Any and all trade secrets, and any and all intellectual property
rights in computer software and computer software products now or hereafter existing, created, acquired or held; 

(c)      Any and all design rights which may be available to Borrower now or hereafter existing, created,
acquired or held; 
 (d)      Any and all claims for damages by way of past, present and future
infringement of any of the rights included above, with the right, but not the obligation, to sue for and collect such damages for said use or infringement of the intellectual property rights identified above; 

(e)      All licenses or other rights to use any of the Copyrights, Patents or Trademarks, and all
license fees and royalties arising from such use to the extent permitted by such license or rights; 

(f)      All amendments, renewals and extensions of any of the Copyrights, Trademarks or Patents; and

 (g)      All proceeds and products of the foregoing, including without limitation all payments under
insurance or any indemnity or warranty payable in respect of any of the foregoing. 
 “Inventory” means all present and future inventory in which
Borrower has any interest. 
 “Investment” means any beneficial ownership of (including stock, partnership or limited liability company interest
or other securities) any Person, or any loan, advance or capital contribution to any Person. 
 “Investment Agreement” means, collectively,
Borrower’s stock purchase and other agreement(s) pursuant to which Borrower most recently issued its preferred stock. 
 “IRC” means the
Internal Revenue Code of 1986, as amended, and the regulations thereunder. 
 “Letter of Credit” means a commercial or standby letter of credit or
similar undertaking issued by Bank at Borrower’s request. 
 “Lien” means any mortgage, lien, deed of trust, charge, pledge, security
interest or other encumbrance. 

  
 3 

 “Loan Documents” means, collectively, this Agreement, any note or notes executed by Borrower, and
any other document, instrument or agreement entered into in connection with this Agreement, all as amended or extended from time to time. 
 “Material
Adverse Effect” means a material adverse effect on (i) the operations, business or financial condition of Borrower and its Subsidiaries taken as a whole, (ii) the ability of Borrower to repay the Obligations or otherwise perform its
obligations under the Loan Documents, or (iii) Borrower’s interest in, or the value, perfection or priority of Bank’s security interest in the Collateral. 

“Negotiable Collateral” means all of Borrower’s present and future letters of credit of which it is a beneficiary, drafts, instruments
(including promissory notes), securities, documents of title, and chattel paper, and Borrower’s Books relating to any of the foregoing. 

“Obligations” means all debt, principal, interest, Bank Expenses and other amounts owed to Bank by Borrower pursuant to this Agreement or any other
agreement (other than any warrant or equity related agreement), whether absolute or contingent, due or to become due, now existing or hereafter arising, including any interest that accrues after the commencement of an Insolvency Proceeding and
including any debt, liability, or obligation owing from Borrower to others that Bank may have obtained by assignment or otherwise. 
 “Patents”
means all patents, patent applications and like protections including without limitation improvements, divisions, continuations, renewals, reissues, extensions and
continuations-in-part of the same. 
 “Periodic Payments” means
all installments or similar recurring payments that Borrower may now or hereafter become obligated to pay to Bank pursuant to the terms and provisions of any instrument, or agreement now or hereafter in existence between Borrower and Bank. 

“Permitted Indebtedness” means: 

(a)      Indebtedness of Borrower in favor of Bank arising under this Agreement or any other Loan
Document; 
 (b)      Indebtedness existing on the Closing Date and disclosed in the Schedule; 

(c)      Indebtedness not to exceed $250,000 in the aggregate at any time secured by a lien described in
clause (c) of the defined term “Permitted Liens,” provided such Indebtedness does not exceed at the time it is incurred the lesser of the cost or fair market value of the property financed with such Indebtedness; 

(d)      The SVB Credit Card for a period of time not to exceed 90 days after the Closing Date; 

(e)      Subordinated Debt; 

(f)      Indebtedness to trade creditors incurred in the ordinary course of business; 

(g)      Indebtedness incurred as a result of endorsing negotiable instruments received in the ordinary
course of business; 
 (h)      Indebtedness permitted under clause (d) of Permitted Investments;
and 
 (i)      Extensions, refinancings and renewals of any items of Permitted Indebtedness, provided
that the principal amount is not increased or the terms modified to impose more burdensome terms upon Borrower or its Subsidiary, as the case may be. 

“Permitted Investment” means: 

(a)      Investments existing on the Closing Date disclosed in the Schedule; 

  
 4 

 (b)      (i) Marketable direct obligations issued or
unconditionally guaranteed by the United States of America or any agency or any State thereof maturing within one year from the date of acquisition thereof, (ii) commercial paper maturing no more than one year from the date of creation thereof and
currently having rating of at least A-2 or P-2 from either Standard & Poor’s Corporation or Moody’s Investors Service, (iii) Bank’s
certificates of deposit maturing no more than one year from the date of investment therein, and (iv) Bank’s money market accounts; (v) Investments in regular deposit or checking accounts held with Bank or as otherwise permitted by,
and subject to the terms and conditions of, Section 6.6 of this Agreement; and (vi) Investments consistent with any investment policy adopted by the Borrower’s board of directors; 

(c)      Investments accepted in connection with Permitted Transfers; 

(d)      Investments (i) of Subsidiaries in or to other Subsidiaries (which are co-Borrowers or secured guarantors and, for Subsidiaries created or acquired after the date hereof, with respect to which Borrower and its Subsidiaries have fully complied with Section 6.8 hereof) or Borrower
and Investments by Borrower in Subsidiaries (which are co-Borrowers or secured guarantors and, for Subsidiaries created or acquired after the date hereof, with respect to which Borrower and its Subsidiaries
have fully complied with Section 6.8 hereof) (ii) of Subsidiaries in or to other Subsidiaries (which are not co-Borrowers or secured guarantors) and (iii) Investments by Borrower in Subsidiaries
(which are not co-Borrowers or secured guarantors) not to exceed $250,000 in the aggregate in any fiscal year; 

(e)      Investments not to exceed $250,000 outstanding in the aggregate at any time consisting of
(i) travel advances and employee relocation loans and other employee loans and advances in the ordinary course of business, and (ii) loans to employees, officers or directors relating to the purchase of equity securities of Borrower or its
Subsidiaries pursuant to employee stock purchase plan agreements approved by Borrower’s Board of Directors; 

(f)      Investments (including debt obligations) received in connection with the bankruptcy or
reorganization of customers or suppliers and in settlement of delinquent obligations of, and other disputes with, customers or suppliers arising in the ordinary course of Borrower’s business; 

(g)      Investments consisting of notes receivable of, or prepaid royalties and other credit extensions,
to customers and suppliers who are not Affiliates, in the ordinary course of business, provided that this subparagraph (g) shall not apply to Investments of Borrower in any Subsidiary; 

(h)      Joint ventures or strategic alliances in the ordinary course of Borrower’s business
consisting of the non-exclusive licensing of technology, the development of technology or the providing of technical support, provided that any cash Investments by Borrower in another Person under this clause
(h) do not exceed $250,000 in the aggregate in any fiscal year; 
 (i)      Investments consisting
of the endorsement of negotiable instruments for deposit or collection or similar transactions in the ordinary course of business; and 

(j)      Investments permitted under Section 7.3. 

“Permitted Licenses” means the following: 

(a)      non-exclusive licenses or sublicenses and similar
arrangements, partnerships and joint ventures on commercially reasonable terms for the use of the property of Borrower or its Subsidiaries in the ordinary course of business; 

(b)      licenses of open source,
over-the-counter software, prepackaged software and other software that is commercially available to the public, and 

(c)      non-exclusive and exclusive licenses for the use of the
Intellectual Property of Borrower or any of its Subsidiaries entered into in the ordinary course of business, provided, that, with respect to each such 

  
 5 

 
license described in clause (c), (i) no Event of Default has occurred or is continuing at the time of such license; (ii) the license constitutes an arms-length transaction, the terms of
which, on their face, do not provide for a sale or legal transfer of title of any Intellectual Property and do not contain an enforceable restriction on the ability of Borrower or any of its Subsidiaries, as applicable, to pledge, grant a security
interest in or lien on, or assign or otherwise Transfer any Intellectual Property; (iii) in the case of any exclusive license, (x) Borrower delivers to the Bank ten (10) days’ prior written notice and a brief summary of the terms
of the proposed license and copies of the final executed licensing documents in connection with the exclusive license promptly upon consummation thereof, and (y) any such license could not result in a legal transfer of title of the licensed
property but may be exclusive in respects other than territory and may be exclusive as to territory only as to discrete geographical areas outside of the United States; and (iv) all upfront payments, royalties, milestone payments or other
proceeds arising from the licensing agreement that are payable to Borrower or any of its Subsidiaries are deposited into a Deposit Account that is governed by a Control Agreement. 

“Permitted Liens” means the following: 

(a)      Any Liens existing on the Closing Date and disclosed in the Schedule (excluding Liens to be
satisfied with the proceeds of the Credit Extensions) or arising under this Agreement, the other Loan Documents, or any other agreement in favor of Bank; 

(b)      Liens for taxes, fees, assessments or other governmental charges or levies, either not
delinquent or being contested in good faith by appropriate proceedings and for which Borrower maintains adequate reserves; 

(c)      Liens not to exceed $250,000 in the aggregate at any time (i) upon or in any Equipment
(other than Equipment financed by a Credit Extension) acquired or held by Borrower or any of its Subsidiaries to secure the purchase price of such Equipment or indebtedness incurred solely for the purpose of financing the acquisition or lease of
such Equipment, or (ii) existing on such Equipment at the time of its acquisition, in each case provided that the Lien is confined solely to the property so acquired and improvements thereon, and the proceeds of such Equipment; 

(d)      Liens incurred in connection with the extension, renewal or refinancing of the indebtedness
secured by Liens of the type described in clauses (a) through (c) above, provided that any extension, renewal or replacement Lien shall be limited to the property encumbered by the existing Lien and the principal amount of the indebtedness
being extended, renewed or refinanced does not increase; 
 (e)      Liens on cash collateral in favor
of Silicon Valley Bank securing for a period of time not to exceed 90 days after the Closing Date, the SVB Credit Card in an amount not to exceed $10,000; 

(f)      Liens securing Subordinated Debt; 

(g)      Permitted Licenses; 

(h)      Liens of carriers, warehousemen, suppliers, or other Persons that are possessory in nature
arising in the ordinary course of business so long as such Liens attach only to Inventory, securing liabilities in the aggregate amount not to exceed $25,000 and which are not delinquent or remain payable without penalty or which are being contested
in good faith and by appropriate proceedings which proceedings have the effect of preventing the forfeiture or sale of the property subject thereto; 

(i)      Liens to secure payment of workers’ compensation, employment insurance, old-age pensions, social security and other like obligations incurred in the ordinary course of business (other than Liens imposed by ERISA); and 

(j)      Liens arising from judgments, decrees or attachments in circumstances not constituting an Event
of Default under Sections 8.4 (attachment) or 8.7 (judgments). 

  
 6 

 “Permitted Transfer” means the conveyance, sale, lease, transfer or disposition by Borrower or any
Subsidiary of: 
 (a)      Inventory in the ordinary course of business; 

(b)      licenses and similar arrangements for the use of the property of Borrower or its Subsidiaries in
the ordinary course of business; 
 (c)      Transfers that constitute Permitted Licenses; 

(d)      worn-out, surplus or obsolete Equipment; 

(e)      grants of security interests and other Liens that constitute Permitted Liens; and 

(f)      other assets of Borrower or its Subsidiaries that do not in the aggregate exceed $250,000 during
any fiscal year. 
 “Person” means any individual, sole proprietorship, partnership, limited liability company, joint venture, trust,
unincorporated organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or governmental agency. 

“Prime Rate” means the variable rate of interest, per annum, most recently announced by Bank, as its “prime rate,” whether or not such
announced rate is the lowest rate available from Bank. 
 “Responsible Officer” means each of the Chief Executive Officer, the Chief Operating
Officer, the Chief Financial Officer, Vice President of Finance, the Secretary and the Controller of Borrower, as well as any other officer or employee identified as an Authorized Officer in the corporate resolution delivered by Borrower to Bank in
connection with this Agreement. 
 “Schedule” means the schedule of exceptions attached hereto and approved by Bank, if any. 

“SOS Reports” means the official reports from the Secretaries of State of each Collateral State, the state where Borrower’s chief executive
office is located, the state of Borrower’s formation and other applicable federal, state or local government offices identifying all current security interests filed in the Collateral and Liens of record as of the date of such report. 

“Subordinated Debt” means any debt incurred by Borrower that is subordinated in writing to the debt owing by Borrower to Bank on terms reasonably
acceptable to Bank (and identified as being such by Borrower and Bank). 
 “Subsidiary” means any corporation, partnership or limited liability
company or joint venture in which (i) any general partnership interest or (ii) more than 50% of the stock, limited liability company interest or joint venture of which by the terms thereof ordinary voting power to elect the Board of
Directors, managers or trustees of the entity, at the time as of which any determination is being made, is owned by Borrower, either directly or through an Affiliate. 

“SVB Credit Card” means Borrower’s existing credit card issued by Silicon Valley Bank with an aggregate limit not to exceed $10,000. 

“Term Loan Maturity Date” means December 21, 2019. 

“Trademarks” means any trademark and servicemark rights, whether registered or not, applications to register and registrations of the same and like
protections, and the entire goodwill of the business of Borrower connected with and symbolized by such trademarks. 
 “Tranche” means any of
Tranche A or Tranche B. 

  
 7 

 “Tranche A” has the meaning assigned in Section 2.1(b)(i). 

“Tranche B” has the meaning assigned in Section 2.l(b)(i). 

“Tranche B Milestones” means (i) the receipt by Borrower of at least $5,500,000 of gross cash proceeds after the Closing Date from the sale of
its Series A equity securities, (ii) Borrower’s achievement of preclinical POC in at least two indications and (iii) Flagship Ventures Management, Inc. (or an Affiliate thereof) confirms to Bank that Flagship Ventures Management,
Inc. (or an Affiliate thereof) is satisfied with Borrower’s preclinical POC achievement relative to plan. 

  
 8 

					
	DEBTOR	 	KALEIDO BIOSCIENCE, INC.	  	
			
	SECURED PARTY:	 	PACIFIC WESTERN BANK	  	

 EXHIBIT B 

COLLATERAL DESCRIPTION ATTACHMENT TO LOAN AND SECURITY AGREEMENT 

All personal property of Borrower (herein referred to as “Borrower” or “Debtor”) whether presently existing or hereafter created or
acquired, and wherever located, including, but not limited to: 
 (a)      all accounts (including
health-care-insurance receivables), chattel paper (including tangible and electronic chattel paper), deposit accounts, documents (including negotiable documents), equipment (including all accessions and additions thereto), financial assets, general
intangibles (including patents, trademarks, copyrights, goodwill, payment intangibles, domain names and software), goods (including fixtures), instruments (including promissory notes), inventory (including all goods held for sale or lease or to be
furnished under a contract of service, and including returns and repossessions), investment property (including securities and securities entitlements), letter of credit rights, money, and all of Debtor’s books and records with respect to any
of the foregoing, and the computers and equipment containing said books and records; 
 (b)      any
and all cash proceeds and/or noncash proceeds of any of the foregoing, including, without limitation, insurance proceeds, and all supporting obligations and the security therefor or for any right to payment. All terms above have the meanings given
to them in the North Carolina Uniform Commercial Code, as amended or supplemented from time to time, including revised Division 9 of the Uniform Commercial Code-Secured Transactions. 

Notwithstanding the foregoing, the Collateral shall not include (i) any property that is nonassignable by its terms without the consent
of the licensor thereof or another party (but only to the extent such prohibition on transfer is enforceable under applicable law, including, without limitation,
§25-9-406 and §25-9-408 of the Code), (ii) any property where the granting of a
security interest therein is contrary to applicable law, provided that upon the cessation of any such restriction or prohibition, such property shall automatically become part of the Collateral, (iii) any property that constitutes the capital stock
of a controlled foreign corporation (as defined in the IRC), in excess of 65% of the voting power of all classes of capital stock of such controlled foreign corporations entitled to vote, (iv) any property (including any attachments, accessions
or replacements) that is subject to a Lien that is permitted pursuant to clauses (c) or (e) of the definition of Permitted Liens, if the grant of a security interest with respect to such property pursuant to this Agreement would be prohibited
by the agreement creating such Permitted Lien or would otherwise constitute a default thereunder, provided, that such property will be deemed “Collateral” hereunder upon the termination and release of such Permitted Liens or (v) any
property that is Intellectual Property, in any medium, of any kind or nature whatsoever, now or hereafter owned or acquired or received by Borrower, or in which Borrower now holds or hereafter acquires or receives any right or interest; provided,
however, that the Collateral shall include all accounts and general intangibles that consist of rights to payment and proceeds from the sale, licensing or disposition of all or any part, or rights in, the foregoing (the “Rights to
Payment”). 
 Notwithstanding the foregoing, if a judicial authority (including a U.S. Bankruptcy Court) holds that a security interest
in the underlying Intellectual Property is necessary to have a security interest in the Rights to Payment, then the Collateral shall automatically, and effective as of December 21, 2015, include the Intellectual Property to the extent and only
to the extent necessary to permit perfection of Bank’s security interest in the Rights to Payment, and further provided, however, that Bank’s enforcement rights with respect to any security interest in the Intellectual Property shall be
absolutely limited to the Rights to Payment only, and Bank shall have no recourse whatsoever with respect to the underlying Intellectual Property. 

  
 1 

 EXHIBIT C 

LOAN ADVANCE / PAYDOWN REQUEST FORM 

[Please refer to New Borrower Kit] 

 EXHIBIT D 

COMPLIANCE CERTIFICATE 

[Please refer to New Borrower Kit] 

 SCHEDULE OF EXCEPTIONS 

Permitted Indebtedness (Exhibit A) – None. 

Permitted Investments (Exhibit A) – None. 

Permitted Liens (Exhibit A) – None. 
 Intellectual
Property (Section 5.4) – 
 Patents: none 

Patent applications: 
  

																	
	 Kaleido # and TITLE
	  	MATTER
TYPE	 	  	US
APPLICATION #	 	  	STATUS	 	  	Filing Date	 
	 GT 001 P1 Glycan Therapeutic Compositions and Uses Thereof for Metabolic Diseases
	  	 	Prov - ORG	 	  	 	62/152,005	 	  	 	Pending	 	  	 	4/23/2015	 
					
	 GT 002 Pl Glycan Therapeutic Compositions and Uses Thereof for Inflammatory Diseases
	  	 	Prov - ORG	 	  	 	62/152,007	 	  	 	Pending	 	  	 	4/23/2015	 
					
	 GT 003 Pl Glycan Therapeutic Compositions and Uses Thereof for Infectious Diseases
	  	 	Prov - ORG	 	  	 	62/152,011	 	  	 	Pending	 	  	 	4/23/2015	 
					
	 GT 004 Pl Glycan Therapeutic Compositions and Uses Thereof for Microbiome Diseases
	  	 	Prov - ORG	 	  	 	62/152,016	 	  	 	Pending	 	  	 	4/23/2015	 
					
	 GT 005 Pl Hybrid Glycan Structures, Therapeutic Compositions and Uses Thereof for Altering the
Microbiota
	  	 	Prov - ORG	 	  	 	62/152,017	 	  	 	Pending	 	  	 	4/23/2015	 
					
	 GT 006 Pl: Glycan Therapeutic Compositions and Uses Thereof for the Modulation of Skin
Microbiota
	  	 	Prov - ORG	 	  	 	62/209,615	 	  	 	Pending	 	  	 	8/25/2015	 
					
	 GT 007 Pl: Glycan Therapeutic Compositions and Uses Thereof for the Modulation of Vaginal
Microbiota
	  	 	Prov - ORG	 	  	 	62/209,618	 	  	 	Pending	 	  	 	8/25/2015	 
					
	 GT 008 Pl: Glycan Therapeutic Compositions and Uses Thereof for the Modulation of Oral
Microbiota
	  	 	Prov - ORG	 	  	 	62/209,626	 	  	 	Pending	 	  	 	8/25/2015	 
					
	 GT 009 Pl: Glycan Therapeutic Compositions and Uses Thereof for the Modulation of Nasal
Microbiota
	  	 	Prov - ORG	 	  	 	62/209,629	 	  	 	Pending	 	  	 	8/25/2015	 
					
	 GT 001 P2 Glycan Therapeutic Compositions And Uses Thereof For Metabolic Diseases
	  	 	Prov - ORG	 	  	 	62/216,993	 	  	 	Pending	 	  	 
 
	4/23/2015
 9/10/2015
	 
  

					
	 GT 002 P2 Glycan Therapeutic Compositions and Uses Thereof for Inflammatory Diseases
	  	 	Prov - ORG	 	  	 	62/216,995	 	  	 	Pending	 	  	 
 
	4/23/2015
 9/10/2015
	 
  

					
	 GT 003 P2 Glycan Therapeutic Compositions and Uses Thereof for Infectious Diseases
	  	 	Prov - ORG	 	  	 	62/216,997	 	  	 	Pending	 	  	 
 
	4/23/2015
 9/10/2015
	 
  

					
	 GT 004 P2 Glycan Therapeutic Compositions and Uses Thereof for Microbiome Diseases
	  	 	Prov - ORG	 	  	 	62/217,002	 	  	 	Pending	 	  	 
 
	4/23/2015
 9/10/2015
	 
  

					
	 GT 010 Pl Glycan Therapeutics Comprising Polyphenols and Uses Thereof in Infectious and
Inflammatory Diseases
	  	 	Prov - ORG	 	  	 	62/238,110	 	  	 	Pending	 	  	 	10/6/2015	 

																	
	 GT 01l Pl Glycan Therapeutics Comprising Polyphenols and uses Thereof in Metabolic and
Microbiome-Associated Diseases
	  	 	Prov - ORG	 	  	 	62/238,112	 	  	 	Pending	 	  	 	10/6/2015	 
					
	 GT 012 Pl: Microbiome Regulators and Uses Thereof in Infectious and Inflammatory Diseases
	  	 	Prov - ORG	 	  	 	62/255,365	 	  	 	Pending	 	  	 	11/13/2015	 
					
	 GT 013 Pl: Microbiome Regulators and Uses Thereof in Microbiome and Metabolic Diseases
	  	 	Prov - ORG	 	  	 	62/255,366	 	  	 	Pending	 	  	 	11/13/2015	 

 Copyright registrations or applications: none 

Trademark, service mark and domain name registrations or applications: 

Trademark and/or service marks 
 The
following mark has been applied for but not yet granted. 
 U.S. Trademark/Service Mark Application Serial No. 86783357 for the mark “KALEIDO”

 Domain name 

www.glycobiome.com 

www.vl32.com 

www.kaleido.com 

 Midori Licensed Patents 

The following patents are licensed from Midori USA, Inc 
  

											
	 MoFo Ref.

Midori Ref.
	  	 Country
	  	 Title
	  	 Application No.
Filing Date
	  	Registration No.
Registration Date	  	 Status

	 70703-20001.00

MID-001US3
	  	United States of America	  	POLYMERIC ACID CATALYSTS AND USES THEREOF	  	 13/406,490
 2/27/2012
	  	9,079,171
 7/14/2015
	  	Granted/Registered
						
	 70703-20001.01

MID-001US4
	  	United States of America	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 14/730,143
 6/3/2015
	  		  	Filed
						
	 70703-20001.40

MID-001WO1
	  	 Patent Cooperation
 Treaty
	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 PCT/US2012/02 6820
 2/27/2012
	  		  	Expired
						
	 70703-20001.41

MID-001AR1
	  	Argentina	  	POLYMERIC ACID CATALYSTS AND USES THEREOF	  	 P20120100642
 2/28/2012
	  		  	Filed
						
	 70703-20001.42

MID-00lJA1
	  	Jamaica	  	POLYMERIC ACID CATALYSTS AND USES THEREOF	  	 1815278
 3/22/2012
	  		  	Filed
						
	 70703-20001.43

MID-001ZA
	  	South Africa	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 201306233
 2/27/2012
	  		  	Filed
						
	 70703-20001.44

MID-001KR
	  	Republic of Korea	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 1020137018658
 2/27/2012
	  		  	Filed
						
	 70703-20001.45

MID-001AU
	  	Australia	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 2012223494
 2/27/2012
	  		  	Filed
						
	 70703-20001.46

MID-001BR
	  	Brazil	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 BR11201302204 73
 2/27/2012
	  		  	Filed
						
	 70703-20001.47

MID-001CA
	  	Canada	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 2864086
 2/27/2012
	  		  	Filed
						
	70703-20001.48 MID-001CN	  	China	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 2012800189012
 2/27/2012
	  		  	Filed
						
	 70703-20001.49

MID-001CO
	  	Colombia	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 13230542
 2/27/2012
	  		  	Filed
						
	 70703-20001.50

M1D-001EP
	  	European Patent Office	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 127092070
 2/27/2012
	  		  	Filed
						
	 70703-20001.51

MID-001ID
	  	Indonesia	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 W00201304395
 2/27/2012
	  		  	Filed
						
	 70703-20001.52

MID-001IN
	  	India	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 7946DELNP201
 3

2/27/2012
	  		  	Filed
						
	70703-20001.53 MID-001MY	  	Malaysia	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	P12013003157 2/27/2012	  		  	Filed
						
	 70703-20001.54

MID-001NZ
	  	New Zealand	  	 POLYMERIC ACID CATALYSTS
 AND USES
THEREOF
	  	 616047
 2/27/2012
	  		  	Filed
						
	 70703-20001.55

MID-001PH
	  	Philippines	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 12013501775
 2/27/2012
	  		  	Filed

											
	 MoFo Ref.

Midori Ref.
	  	 Country
	  	 Title
	  	 Application No.
Filing Date
	  	 Registration No.

Registration Date
	  	 Status

						
	 70703-20001.56

MID-001TH
	  	Thailand	  	POLYMERIC ACID CATALYSTS AND USES THEREOF	  	 1301004754
 2/27/2012
	  		  	Filed
						
	 70703-20001.57

MID-001CL
	  	Chile	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 24632013
 2/27/2012
	  		  	Filed
						
	 70703-20001.58

MID-001RU
	  	 Russian
 Federation
	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 2013143822
 2/27/2012
	  		  	Filed
						
	 70703-20001.59

MID-001SG
	  	Singapore	  	POLYMERIC ACID CATALYSTS AND USES THEREOF	  	 2013064654
 2/27/2012
	  		  	Filed
						
	 70703-20001.60

MID-001MX
	  	Mexico	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 MXa201300992
 0

2/27/2012
	  		  	Filed
						
	 70703-20002.00

MID-001US4
	  	United States of America	  	POLYMERIC ACID CATALYSTS AND USES THEREOF	  	 13/406,517
 2/27/2012
	  	 8,466,242
 6/18/2013
	  	Granted/Registered
						
	 70703-20002.10

MID-001US5
	  	United States of America	  	POLYMERIC ACID CATALYSTS AND USES THEREOF	  	 13/657,724
 2/27/2012
	  	8,476,388 7/2/2013	  	Granted/Registered
						
	 70703-20002.11

MID-001US6
	  	United States of America	  	POLYMERIC ACID CATALYSTS AND USES THEREOF	  	 13/865,048
 4/17/2013
	  		  	Filed
						
	 70703-20004.40

MID-003WO1
	  	 Patent
 Cooperation

Treaty
	  	 METHOD OF PRODUCING
 MONOETHYLENE
GLYCOL
	  	 PCT/US2013/03 7862
 4/23/2013
	  		  	Abandonment Pending
						
	 70703-20005.00

MID-004US1
	  	United States of America	  	POLYMERIC AND SOLID-SUPPORTED CATALYSTS, AND METHODS OF DIGESTING CELLULOSIC MATERIALS USING	  	 14/423,697
 8/23/2013
	  		  	Filed
						
	 70703-20005.40

MID-004WO1
	  	 Patent
 Cooperation

Treaty
	  	POLYMERIC AND SOLID-SUPPORTED CATALYSTS, AND METHODS OF DIGESTING CELLLOSIC MATERIALS USING SUCH CATALYSTS	  	 PCT/US2013/05 6389
 8/23/2013
	  		  	Filed
						
	 70703-20005.42

MID-004CN1
	  	China	  	POLYMERIC AND SOLID-SUPPORTED CATALYSTS, AND METHODS OF DIGESTING CELLLOSIC MATERIALS USING SUCH CATALYSTS	  	 2013800550503
 8/23/2013
	  		  	Filed
						
	 70703-20005.43

MID-004EP1
	  	 European
 Patent Office
	  	POLYMERIC AND SOLID-SUPPORTED CATALYSTS, AND METHODS OF DIGESTING CELLLOSIC MATERIALS USING SUCH CATALYSTS	  	 138312285
 8/23/2013
	  		  	Filed
						
	 70703-20005.44

MID-004KR1
	  	 Republic of
 Korea
	  	POLYMERIC AND SOLID-SUPPORTED CATALYSTS, AND METHODS OF DIGESTING CELLLOSIC MATERIALS USING SUCH CATALYSTS	  	 1020157007481
 8/23/2013
	  		  	Filed
						
	 70703-20007.00

MID-006US2
	  	United States of America	  	METHODS OF PRODUCING SUGARS FROM BIOMASS FEEDSTOCKS	  	 13/831,495
 3/14/2013
	  		  	Filed
						
	 70703-20009.00

MID-008US1
	  	United States of America	  	POLYMERIC AND SOLID-SUPPORTED CATALYSTS, AND METHODS OF DIGESTING LIGNIN-CONTAINING MATERIALS USING SUCH CATALYSTS	  	 14/423,698
 8/23/2013
	  		  	Filed

											
	 MoFo Ref.
Midori Ref.
	  	 Country
	  	 Title
	  	 Application No.
Filing Date
	  	 Registration No.

Registration Date
	  	 Status

						
	 70703-20009.40

MID-008WO1
	  	 Patent
 Cooperation

Treaty
	  	POLYMERIC AND SOLID SUPPORTED CATALYSTS, AND METHODS OF DIGESTING LIGNIN CONTAINING MATERIAL USING SUCH CATALYSTS	  	 PCT/US2013/05 6462
 8/23/2013
	  		  	Filed
						
	 70703-20009.41

MID-008EP1
	  	 European
 Patent Office
	  	POLYMERIC AND SOLID SUPPORTED CATALYSTS, AND METHODS OF DIGESTING LIGNIN CONTAINING MATERIAL USING SUCH CATALYSTS	  	 138306097
 8/23/2013
	  		  	Filed
						
	 70703-20011.40

MID-010WOl
	  	 Patent
 Cooperation

Treaty
	  	POLYMERIC IONIC SALT CATALYSTS AND METHODS OF PRODUCING THEREOF	  	 PCT/US2014/02 4177
 3/12/2014
	  		  	Filed
						
	 70703-20012.00

MID-011US2
	  	United States of America	  	OLIGOSACCHARIDE COMPOSITIONS AND METHODS FOR PRODUCING THEREOF	  	 14/795,720
 7/9/2015
	  		  	Filed
						
	 70703-20012.40

MID-011WO1
	  	 Patent
 Cooperation

Treaty
	  	METHODS FOR PRODUCING OLIGOSACCHARIDES	  	 PCT/US15/3979
 5

7/9/2015
	  		  	Filed
						
	 70703-30001.00

MID-001US1
	  	United States of America	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	61/447,311 2/28/2011	  		  	Expired
						
	 70703-30001.01

MID-001US2
	  	United States of America	  	SYSTEMS AND METHODS FOR PRODUCTION OF SOLID ACID CATALYSTS	  	 61/522,351
 8/11/2011
	  		  	Expired
						
	 70703-30003.00

MID-002US1
	  	United States of America	  	METHODS OF DEGRADING REFRACTORY BIOMASS	  	 61/611,930
 3/16/2012
	  		  	Expired
						
	 70703-30004.00

MID-003US1
	  	United States of America	  	BIO-BASED POLYMERS AND METHODS OF PRODUCING THEREOF	  	 61/637,370
 4/24/2012
	  		  	Expired
						
	 70703-30005.00

MID-004US1
	  	United States of America	  	SOLID-SUPPORTED CATALYSTS, METHODS OF PRODUCING THEREOF, AND USES THEREOF	  	 61/693,200
 8/24/2012
	  		  	Expired
						
	 70703-30006.00

MID-005US1
	  	United States of America	  	POLYMERIC METAL CATALYSTS AND USES THEREOF	  	 61/693,207
 8/24/2012
	  		  	Expired
						
	 70703-30007.00

MID-006US1
	  	United States of America	  	METHODS OF PRODUCING SUGARS FROM BIOMASS FEEDSTOCKS	  	 61/693,210
 8/24/2012
	  		  	Expired
						
	 70703-30008.00

MID-007US1
	  	United States of America	  	METHODS OF PRODUCING A FOOD AGENT FROM BIOMASS	  	 61/693,213
 8/24/2012
	  		  	Expired
						
	 70703-30009.00

MID-008US1
	  	United States of America	  	SOLID BASE CATALYSTS, METHODS OF PRODUCING THEREOF, AND USES THEREOF	  	 61/693,216
 8/24/2012
	  		  	Expired
						
	 70703-30010.00

MID-009USI
	  	United States of America	  	BIO-BASED POLYMERS AND METHODS OF PRODUCING THEREOF	  	 61/743,931
 9/14/2012
	  		  	Expired
						
	 70703-30011.00

MID-010
	  	United States of America	  	POLYMERIC IONIC SALT CATALYSTS AND METHODS OF PRODUCING THEREOF	  	 61/786,230
 3/14/2013
	  		  	Expired
						
	 70703-30012.00

MID-011
	  	United States of America	  	METHODS FOR PRODUCING OLIGOSACCHARIDES	  	 62/022,579
 7/9/2014
	  		  	Expired
						
	 70703-30012.01

MID-012
	  	United States of America	  	OLIGOSACCHARIDE COMPOSITIONS AND METHODS FOR PRODUCING THEREOF	  	 62/108,035
 1/26/2015
	  		  	Filed
						
	 70703-30013.00

MID-013
	  	United States of America	  	OLIGOSACCHARIDE COMPOSITIONS FOR USE AS FOOD INGREDIENTS AND METHODS OF PRODUCING THEREOF	  	 62/108,036
 1/26/2015
	  		  	Filed

											
	 MoFo Ref.

Midori Ref.
	  	 Country
	  	 Title
	  	 Application No.
Filing Date
	  	 Registration No.

Registration Date
	  	 Status

						
	 70703-30014.00

MID-014
	  	United States of America	  	OLIGOSACCHARIDE COMPOSITIONS FOR USE AS ANIMAL FEED AND METHODS OF PRODUCING THEREOF	  	 62/108,037
 1/26/2015
	  		  	Filed
						
	 70703-30015.00

MID-015
	  	United States of America	  	OLIGOSACCHARIDE COMPOSITIONS FOR USE IN NUTRITIONAL AND PHARMACEUTICAL COMPOSITIONS, AND METHODS OF PRODUCING THEREOF	  	 62/108,038
 1/26/2015
	  		  	Filed
						
	 70703-30016.00

MID-016
	  	United States of America	  	 METHODS OF TREATING METABOLIC DISORDERS USING OLIGOSACCHARIDE

COMPOSITIONS
	  	 62/108,039
 1/26/2015
	  		  	Filed
						
	 70703-30017.00

MID-017
	  	United States of America	  	METHODS OF PRODUCING ANHYDROSUGAR ALCOHOLS	  	 62/108,460
 1/27/2015
	  		  	Filed

 Prior Names (Section 5.5) – VL32, Inc. 

Litigation (Section 5.6) – None. 
 Inbound
Licenses (Section 5.12) – License Agreement between the Company and Midori USA, Inc. effective as of June 16, 2015 

 FIRST AMENDMENT 

TO 
 LOAN AND SECURITY
AGREEMENT 
 This First Amendment to Loan and Security Agreement (the “Amendment”) is made and entered into as of
January 6, 2017 by and between PACIFIC WESTERN BANK, a California state chartered bank (“Bank”), and KALEIDO BIOSCIENCES, INC. (“Borrower”). 

RECITALS 
 Borrower and Bank are
parties to that certain Loan and Security Agreement dated as of December 21, 2015 (as amended from time to time, the “Agreement”). The parties desire to amend the Agreement in accordance with the terms of this Amendment.

 NOW, THEREFORE, the parties agree as follows: 
  

	1)	 A new Section 2.1(c) is hereby added to the Agreement, as follows: 

(c) Usage of Credit Card Services Under the Credit Card Line. 

(i) Usage Period. Subject to and upon the terms and conditions of this Agreement, at any time from the First Amendment
Effective Date through the Credit Card Maturity Date, Borrower may use the Credit Card Services (as defined below) in amounts and upon terms as provided in Section 2.1(c)(ii) below. 

(ii) Credit Card Services. Subject to and upon the terms and conditions of this Agreement, Borrower may request
corporate credit cards and standard and e-commerce merchant account services from Bank (collectively, the “Credit Card Services”). The aggregate limit of the corporate credit cards and merchant
credit card processing reserves shall not exceed the Credit Card Line. The terms and conditions (including repayment and fees) of such Credit Card Services shall be subject to the terms and conditions of Bank’s standard forms of application and
agreement for the Credit Card Services, which Borrower hereby agrees to execute. 
 (iii) Collateralization of
Obligations Extending Beyond Maturity. If Borrower has not cash secured its obligations with respect to any Credit Card Services by the Credit Card Maturity Date, then, effective as of such date, the balance in any deposit accounts held by Bank
and the certificates of deposit or time deposit accounts issued by Bank in Borrower’s name (and any interest paid thereon or proceeds thereof, including any amounts payable upon the maturity or liquidation of such certificates or accounts),
shall automatically secure such obligations to the extent of the then continuing or outstanding Credit Card Services. Borrower authorizes Bank to hold such balances in pledge and to decline to honor any drafts thereon or any requests by Borrower or
any other Person to pay or otherwise transfer any part of such balances for so long as the applicable Credit Card Services are outstanding or continue. 

  
 1 

	2)	 The following defined terms are hereby added in Exhibit A to the Agreement, as follows: 

“Credit Card Line” means a Credit Extension of up to $30,000, to be used exclusively for the provision of Credit Card
Services. 
 “Credit Card Maturity Date” means January 5, 2018. 

“First Amendment Effective Date” means January 6, 2017. 

 

	3)	 The following defined term in Exhibit A to the Agreement is hereby amended and restated, as follows:

 “Credit Extension” means each Term Loan, the Credit Card Services provided under the Credit
Card Line, or any other extension of credit by Bank to or for the benefit of Borrower hereunder. 
  

	4)	 Unless otherwise defined, all initially capitalized terms in this Amendment shall be as defined in the
Agreement. The Agreement, as amended hereby, shall be and remain in full force and effect in accordance with its respective terms and hereby is ratified and confirmed in all respects. Except as expressly set forth herein, the execution, delivery,
and performance of this Amendment shall not operate as a waiver of, or as an amendment of, any right, power, or remedy of Bank under the Agreement, as in effect prior to the date hereof. Borrower ratifies and reaffirms the continuing effectiveness
of all agreements entered into in connection with the Agreement. 

  

	5)	 Borrower represents and warrants that the representations and warranties contained in the Agreement are true
and correct as of the date of this Amendment. 

  

	6)	 This Amendment may be executed in two or more counterparts, each of which shall be deemed an original, but all
of which together shall constitute one instrument. 

  

	7)	 As a condition to the effectiveness of this Amendment, Bank shall have received, in form and substance
satisfactory to Bank, the following: 

 a) this Amendment, duly executed by Borrower; 

b) a certificate of Borrower with respect to incumbency and resolutions authorizing the execution and delivery of this
Amendment; 
 c) payment for all Bank Expenses incurred through the date of this Amendment, including Bank’s expenses
for the documentation of this Amendment and any UCC, good standing or intellectual property search or filing fees, which may be debited from any of Borrower’s accounts; and 

d) such other documents and completion of such other matters, as Bank may reasonably deem necessary or appropriate. 

[Signature Page Follows] 

  
 2 

 IN WITNESS WHEREOF, the undersigned have executed this Amendment as of the first date above written. 

 

									
	KALEIDO BIOSCIENCES, INC.	 		 	PACIFIC WESTERN BANK
					
	By:	 	 /s/ Geoffrey von Maltzahn
	 		 	By:	 	 /s/ Scott Hansen

	Name:	 	Geoffrey von Maltzahn	 		 	Name:	 	Scott Hansen
	Title:	 	President	 		 	Title:	 	Vice President

 [Signature Page to First Amendment to Loan and Security Agreement] 

  
 3 

 SECOND AMENDMENT AND JOINDER 

TO 
 LOAN AND SECURITY
AGREEMENT 
 This Second Amendment and Joinder to Loan and Security Agreement (this “Second Amendment and
Joinder”), dated as of June 8, 2017, is executed and delivered by CADENA BIO, INC., a Delaware corporation (“New Borrower”), KALEIDO BIOSCIENCES, INC., a Delaware corporation
(“Borrower”), and PACIFIC WESTERN BANK, a California state chartered bank (“Bank”). Capitalized terms used herein but not otherwise defined herein shall have the meanings ascribed to those terms in the Loan
Agreement (as defined below). 
 RECITALS 

a. Borrower and Bank are parties to that certain Loan and Security Agreement dated as of December 21, 2015 (as amended from time to time,
the “Original Loan Agreement”). 
 b. From and after the date hereof (the “Effective Date”), New Borrower,
Borrower, and Bank desire to amend and supplement the terms and provisions of the Original Loan Agreement as provided herein, and the Original Loan Agreement, as amended and supplemented by this Second Amendment and Joinder, and as may be hereafter
further supplemented, amended, modified or restated from time to time, shall be referred to collectively as the “Loan Agreement.” 

c. Bank desires that New Borrower execute this Second Amendment and Joinder for the purpose of acknowledging that it is and shall be a borrower
under the Loan Agreement and the other Loan Documents. 
 d. New Borrower has read and approved the Loan Documents and has asked Bank to
agree to allow New Borrower to become a party to the Loan Documents in order to facilitate its ability to continue to operate its business by achieving a stronger financial base for itself and its affiliated companies. 

NOW, THEREFORE, in consideration of the premises herein contained, and for other good and valuable consideration (the receipt,
sufficiency and adequacy of which are hereby acknowledged), the parties hereto (intending to be legally bound) hereby agree as follows: 
 1.
Incorporation. The foregoing preamble and recitals are incorporated herein by this reference. 
 2. Joinder and Assumption.
From and after the Effective Date, New Borrower hereby absolutely and unconditionally: 
 (a) (i) joins as and becomes a party to the
Loan Agreement as a Borrower thereunder, (ii) assumes, as a joint and several obligor thereunder, all of the Obligations, liabilities and indemnities of a Borrower under the Loan Agreement and all other Loan Documents, and (iii) covenants
and agrees to be bound by and adhere to all of the terms, covenants, waivers, releases, agreements and conditions of or respecting a Borrower with respect to the Loan Agreement and the other Loan Documents and all of the representations and
warranties contained in the Loan Agreement (in the manner set forth in Section 4 of this Second Amendment and Joinder) and the other Loan Documents with respect to New Borrower; and 

  

 (b) collaterally assigns and hereby grants to Bank a continuing security interest in all of
New Borrower’s now owned and existing and hereafter acquired and arising Collateral, as collateral security for the prompt and complete payment and performance when due (whether at the stated maturity, by acceleration or otherwise) of all of
the Obligations. New Borrower hereby authorizes Bank to file at any time uniform commercial code financing statements in such jurisdictions and offices as Bank deems necessary in connection with the perfection of a security interest in all of New
Borrower’s now owned or hereafter arising or acquired Collateral, including, without limitation, accounts receivable, deposit accounts, equipment, general intangibles, inventory, and any and all other personal property of New Borrower, and all
products, substitutions, replacements, and proceeds of such property and assets, in each case, as set forth in and subject to the terms and provisions of the Loan Agreement. New Borrower has read the Loan Agreement and affirmatively grants to Bank
all rights to New Borrower’s assets as set forth in said Loan Agreement and the Loan Documents. 
 From and after the Effective Date,
any reference to the term “Borrower” in the Loan Agreement shall also include New Borrower. Except as expressly provided herein, the Loan Agreement remains in full force and effect and is hereby ratified and confirmed in all respects. 

3. Amendments to Loan Agreement. 

(a) Section 7.8 of the Loan Agreement is hereby amended and restated, as follows: 

7.8 Capitalized Expenditures. Make Capitalized Expenditures, in the aggregate in any fiscal year of Borrower, in excess
of 175% of the amount approved by Borrower’s Board of Directors and set forth in the most recently approved operating plan delivered to Bank in accordance with Section 6.2(iii) of this Agreement. 

(b) A new subsection (j) is hereby added to the defined term “Permitted Indebtedness” in Exhibit A to the Loan
Agreement, as follows: 
 (j) Indebtedness not to exceed $750,000 in the aggregate at any time incurred pursuant to operating
leases for Equipment. 
 (c) A new subsection (k) is hereby added to the defined term “Permitted Liens” in
Exhibit A to the Loan Agreement, as follows: 
 (k) Liens securing Indebtedness referred to in clause (j) of the defined
term “Permitted Indebtedness”, in each case provided that the Lien is confined solely to the property subject to such lease. 

  

 (d) The following defined term in Exhibit A to the Loan Agreement is hereby
amended and restated, as follows: 
 “Credit Card Line” means a Credit Extension of up to $100,000, to be used
exclusively for the provision of Credit Card Services. 
 (e) Subsection (c) of the defined term “Permitted
Indebtedness” in Exhibit A to the Loan Agreement is hereby amended and restated, as follows: 
 (c) Indebtedness not to
exceed $750,000 in the aggregate at any time secured by a lien described in clause (c) of the defined term “Permitted Liens”, provided such Indebtedness does not exceed at the time it is incurred the lesser of the cost or fair market
value of the property financed with such Indebtedness; 
 (f) Subsection (c) of the defined term “Permitted
Liens” in Exhibit A to the Loan Agreement is hereby amended and restated, as follows: 
 (c) Liens not to exceed
$750,000 in the aggregate at any time (i) upon or in any Equipment (other than Equipment financed by a Credit Extension) acquired or held by Borrower or any of its Subsidiaries to secure the purchase price of such Equipment or indebtedness
incurred solely for the purpose of financing the acquisition or lease of such Equipment, or (ii) existing on such Equipment at the time of its acquisition, in each case provided that the Lien is confined solely to the property so acquired and
improvements thereon, and the proceeds of such Equipment; 
 (g) A new Article 13 is hereby added to the Loan Agreement, as
follows: 
  

	 	13.	 CO-BORROWER PROVISIONS. 

13.1 Primary Obligation. This Agreement is a primary and original obligation of each Borrower and shall remain in effect
notwithstanding future changes in conditions, including any change of law or any invalidity or irregularity in the creation or acquisition of any Obligations or in the execution or delivery of any agreement between Bank and any Borrower. Each
Borrower shall be liable for existing and future Obligations as fully as if all Credit Extensions were advanced to such Borrower. Bank may rely on any certificate or representation made by any Borrower as made on behalf of, and binding on, such
Borrower and each other Borrower, including without limitation Loan Advance / Paydown Request Forms, Borrowing Base Certificates and Compliance Certificates. 

13.2 Enforcement of Rights. Each Borrower is jointly and severally liable for the Obligations, and Bank may proceed
against any Borrower to enforce the Obligations without waiving its right to proceed against any other Borrower. 

  

 13.3 Borrower as Agents. Each Borrower appoints each other Borrower
as its agent with all necessary power and authority to give and receive notices, certificates or demands for and on behalf of each Borrower, to act as disbursing agent for receipt of any Credit Extensions on behalf of each Borrower and to apply to
Bank on behalf of each Borrower for Credit Extensions, any waivers and any consents. This authorization cannot be revoked, and Bank need not inquire as to each Borrower’s authority to act for or on behalf of a Borrower. 

13.4 Subrogation and Similar Rights. Notwithstanding any other provision of this Agreement or any other Loan Document,
each Borrower irrevocably waives all rights that it may have at law or in equity (including, without limitation, any law subrogating such Borrower to the rights of Bank under the Loan Documents) to seek contribution, indemnification, or any other
form of reimbursement from any other Borrower, or any other Person now or hereafter primarily or secondarily liable for any of the Obligations, for any payment made by such Borrower with respect to the Obligations in connection with the Loan
Documents or otherwise and all rights that it might have to benefit from, or to participate in, any security for the Obligations as a result of any payment made by such Borrower with respect to the Obligations in connection with the Loan Documents
or otherwise. Any agreement providing for indemnification, reimbursement or any other arrangement prohibited under this Section 13.4 shall be null and void. If any payment is made to a Borrower in contravention of this Section 13.4, such
Borrower shall hold such payment in trust for Bank and such payment shall be promptly delivered to Bank for application to the Obligations, whether matured or unmatured. 

13.5 Waivers of Notice. Except as otherwise provided in this Agreement, each Borrower waives notice of acceptance
hereof; notice of the existence, creation or acquisition of any of the Obligations; notice of an Event of Default; notice of the amount of the Obligations outstanding at any time; notice of intent to accelerate; notice of acceleration; notice of any
adverse change in the financial condition of any other Borrower or of any other fact that might increase the Borrower’s risk; presentment for payment; demand; protest and notice thereof as to any instrument; default; and all other notices and
demands to which the Borrower would otherwise be entitled. Each Borrower waives any defense arising from any defense of any other Borrower, or by reason of the cessation from any cause whatsoever of the liability of any other Borrower. Bank’s
failure at any time to require strict performance by any Borrower of any provision of the Loan Documents shall not waive, alter or diminish any right of Bank thereafter to demand strict compliance and performance therewith. Nothing contained herein
shall prevent Bank from foreclosing on the Lien of any deed of trust, mortgage or other security instrument, or exercising any rights available thereunder, and the exercise of any such rights shall not constitute a legal or equitable discharge of
any Borrower. Each Borrower also waives any defense arising from any act or omission of Bank that changes the scope of the Borrower’s risks hereunder. 

13.6 Subrogation Defenses. Each Borrower hereby waives any defense based on impairment or destruction of its subrogation
or other rights against any other Borrower and waives all benefits which might otherwise be available to it under any statutory or common law suretyship defenses or marshalling rights, now and hereafter in effect. 

  

 13.7 Right to Settle, Release. 

(a) The liability of each Borrower hereunder shall not be diminished by (i) any agreement, understanding or
representation that any of the Obligations is or was to be guaranteed by another Person or secured by other property, or (ii) any release or unenforceability, whether partial or total, of rights, if any, which Bank may now or hereafter have
against any other Person, including another Borrower, or property with respect to any of the Obligations. 
 (b)
Without affecting the liability of any Borrower hereunder, Bank may (i) compromise, settle, renew, extend the time for payment, change the manner or terms of payment, discharge the performance of, decline to enforce, or release all or any of
the Obligations with respect to a Borrower, (ii) grant other indulgences to a Borrower in respect of the Obligations, (iii) modify in any manner any documents relating to the Obligations with respect to a Borrower, (iv) release,
surrender or exchange any deposits or other property securing the Obligations, whether pledged by a Borrower or any other Person, or (v) compromise, settle, renew, or extend the time for payment, discharge the performance of, decline to
enforce, or release all or any obligations of any guarantor, endorser or other Person who is now or may hereafter be liable with respect to any of the Obligations. 

13.8 Subordination. All indebtedness of a Borrower now or hereafter arising held by another Borrower is subordinated to
the Obligations, and the Borrower holding the indebtedness shall take all actions reasonably requested by Bank to effect, to enforce and to give notice of such subordination. 

(h) Exhibit B to the Loan Agreement is hereby supplemented with Exhibit B-1 in the form
attached hereto as Appendix I. 
 4. Representations and Warranties. New Borrower hereby represents and warrants to Bank, which
representations and warranties shall survive the execution and delivery hereof, that: (a) this Second Amendment and Joinder is the legally valid and binding obligation of New Borrower, enforceable against New Borrower in accordance with its
terms (except as enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting the enforcement of creditors’ rights generally and by general equitable principles (whether enforcement is
sought by proceedings in equity or at law)), and (b) except as otherwise set forth below, each of the representations and warranties contained in the Loan Agreement, as well as all other representations and warranties contained in the other
Loan Documents, are true and correct in all respects to the extent required under the Loan Agreement. 

  

 5. Successors and Assigns. This Second Amendment and Joinder shall be binding upon
New Borrower, Borrower, and Bank and Bank’s successors and assigns, and shall inure to the benefit of New Borrower, Borrower, Bank and Bank’s successors and assigns. No other person or entity shall be a direct or indirect legal beneficiary
of, or have any direct or indirect cause of action or claim in connection with, this Second Amendment and Joinder. New Borrower may not assign or transfer any of its rights or obligations under this Second Amendment and Joinder without the prior
written consent of Bank. 
 6. Severability; Construction. Wherever possible, each provision of this Second Amendment and Joinder
shall be interpreted in such a manner so as to be effective and valid under applicable law, but if any provision of this Second Amendment and Joinder shall be prohibited by or invalid under applicable law, such provision shall be ineffective to the
extent of such provision or invalidity, without invalidating the remainder of such provision or the remaining provisions of this Second Amendment and Joinder. All obligations of Borrower and New Borrower and rights of Bank expressed herein shall be
in addition to and not in limitation of those provided by applicable law. 
 7. Counterparts; Facsimile and other Electronic
Transmission. This Second Amendment and Joinder may be executed in any number of counterparts and by the different parties hereto on separate counterparts and each such counterpart shall be deemed to be an original, but all such counterparts
shall together constitute but one and the same Second Amendment and Joinder. Receipt of an executed signature page to this Second Amendment and Joinder by facsimile or other electronic transmission shall constitute for all purposes effective
delivery thereof. Electronic records of this executed Second Amendment and Joinder maintained by Bank shall be deemed to be originals. 
 8.
GOVERNING LAW. THIS SECOND AMENDMENT AND JOINDER SHALL BE A CONTRACT MADE UNDER AND BE CONSTRUED, ENFORCED AND GOVERNED BY THE LAWS OF THE STATE OF NORTH CAROLINA APPLICABLE TO CONTRACTS MADE AND TO BE PERFORMED ENTIRELY
WITHIN SUCH STATE, WITHOUT REGARD TO CONFLICT OF LAW PRINCIPLES. 
 9. WAIVER OF JURY TRIAL. BANK, NEW BORROWER,
AND BORROWER WAIVE ANY RIGHT TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS SECOND AMENDMENT AND JOINDER OR ANY TRANSACTION CONTEMPLATED HEREIN, INCLUDING CLAIMS BASED ON CONTRACT, TORT, BREACH OF DUTY AND ALL
OTHER COMMON LAW OR STATUTORY BASES. ALL DISPUTES, CONTROVERSIES, CLAIMS, ACTIONS AND SIMILAR PROCEEDINGS ARISING WITH RESPECT TO BORROWER’S OR NEW BORROWER’S ACCOUNTS OR ANY RELATED AGREEMENT OR TRANSACTION SHALL BE BROUGHT IN THE GENERAL
COURT OF JUSTICE OF NORTH CAROLINA SITTING IN DURHAM COUNTY, NORTH CAROLINA OR THE UNITED STATES DISTRICT COURT FOR THE MIDDLE DISTRICT OF NORTH CAROLINA, EXCEPT AS PROVIDED BELOW WITH RESPECT TO ARBITRATION OF SUCH MATTERS. IF THE JURY WAIVER SET
FORTH IN THIS SECTION IS NOT ENFORCEABLE, THEN ANY DISPUTE, CONTROVERSY OR CLAIM ARISING OUT OF OR RELATING TO THIS SECOND AMENDMENT AND JOINDER OR ANY OF THE TRANSACTIONS CONTEMPLATED HEREIN WILL BE FINALLY SETTLED BY BINDING

  

 
ARBITRATION IN DURHAM COUNTY, NORTH CAROLINA IN ACCORDANCE WITH THE THEN-CURRENT COMMERCIAL ARBITRATION RULES OF THE AMERICAN ARBITRATION ASSOCIATION BY ONE ARBITRATOR APPOINTED IN ACCORDANCE
WITH SAID RULES. THE ARBITRATOR SHALL APPLY NORTH CAROLINA LAW TO THE RESOLUTION OF ANY DISPUTE, WITHOUT REFERENCE TO RULES OF CONFLICTS OF LAW OR RULES OF STATUTORY ARBITRATION. JUDGMENT ON THE AWARD RENDERED BY THE ARBITRATOR MAY BE ENTERED IN ANY
COURT HAVING JURISDICTION THEREOF. NOTWITHSTANDING THE FOREGOING, THE PARTIES MAY APPLY TO ANY COURT OF COMPETENT JURISDICTION FOR PRELIMINARY OR INTERIM EQUITABLE RELIEF, OR TO COMPEL ARBITRATION IN ACCORDANCE WITH THIS PARAGRAPH. THE EXPENSES OF
THE ARBITRATION, INCLUDING THE ARBITRATOR’S FEES, REASONABLE ATTORNEYS’ FEES AND EXPERT WITNESS FEES, INCURRED BY THE PARTIES TO THE ARBITRATION, MAY BE AWARDED TO THE PREVAILING PARTY, IN THE DISCRETION OF THE ARBITRATOR, OR MAY BE
APPORTIONED BETWEEN THE PARTIES IN ANY MANNER DEEMED APPROPRIATE BY THE ARBITRATOR. UNLESS AND UNTIL THE ARBITRATOR DECIDES THAT ONE PARTY IS TO PAY FOR ALL (OR A SHARE) OF SUCH EXPENSES, THE PARTIES SHALL SHARE EQUALLY IN THE PAYMENT OF THE
ARBITRATOR’S FEES AS AND WHEN BILLED BY THE ARBITRATOR. 
 10. Conditions Precedent to Effectiveness of Second Amendment and
Joinder. The agreement of Bank to enter into this Second Amendment and Joinder on the date hereof is subject to the condition precedent that Bank shall have received, in form and substance satisfactory to Bank, each the following items and
completed each of the following requirements: 
 (a) this Second Amendment and Joinder, duly executed by New Borrower and Borrower;

 (b) an officer’s certificate of New Borrower with respect to incumbency and resolutions authorizing the execution and
delivery of this Second Amendment and Joinder; 
 (c) a financing statement (Form UCC-1) with
respect to New Borrower; 
 (d) payment for all Bank Expenses, including Bank’s expenses in the documentation of this Second
Amendment and Joinder and any other related documentation, and any UCC, good standing or intellectual property search or filing fees, which may be debited from any account of Borrower or New Borrower with Bank; 

(e) current SOS Reports indicating that, as to New Borrower, except for Permitted Liens, there are no other security interests or Liens
of record in the Collateral; 
 (f) a Borrower Information Certificate from New Borrower; and 

(g) such other documents or certificates, and completion of such other matters, as Bank may reasonably deem necessary or appropriate.

  

 11. Notices. The address for notices to be sent to Bank and for the payment of all
sums due under the Loan Agreement is correctly set forth therein, and Bank confirms said address is: 
 Pacific Western Bank 

406 Blackwell Street, Suite 240 

Durham, NC 27701 
 Attn: Loan
Operations Manager 
 FAX: 919-314-3080 

For purposes hereof, the address for notices to be sent to New Borrower is: 

For CADENA BIO, INC.: 
 c/o
Kaleido Biosciences 
 18 Crosby Drive 

Bedford, MA 01730 
 Attn:
President 
 FAX: 

[Signature Page Follows] 

  

 IN WITNESS WHEREOF, the undersigned have caused this Second Amendment and Joinder to
Loan and Security Agreement to be duly executed and delivered as of the date first above written. 
  

			
	NEW BORROWER:
	
	CADENA BIO, INC.
		
	By:	 	 /s/ Geoffrey von Maltzahn

	Name:	 	Geoffrey von Maltzahn
	Title:	 	President

  

			
	 BANK:

	
	 PACIFIC WESTERN BANK

		
	 By:
	 	 /s/ Scott Hansen

	 Name:
	 	 Scott Hansen

	 Title:
	 	 SVP

 Acknowledged and Agreed: 

BORROWER: 
  

			
	KALEIDO BIOSCIENCES, INC.
		
	By:	 	 /s/ Jeffrey Moore

	Name:	 	Jeffrey Moore
	Title:	 	SVP, Finance & Administration, Secretary & Treasurer

 [Signature Page to Second Amendment and Joinder to 

Loan and Security Agreement] 

 APPENDIX I 
  

			
	DEBTOR:	  	CADENA BIO, INC.
		
	SECURED PARTY:	  	PACIFIC WESTERN BANK

 EXHIBIT B-1 

COLLATERAL DESCRIPTION ATTACHMENT TO LOAN AND SECURITY 

AGREEMENT 
 All personal property of Debtor
(herein referred to as “Borrower” or “Debtor”) whether presently existing or hereafter created or acquired, and wherever located, including, but not limited to: 

(a) all accounts (including health-care-insurance receivables), chattel paper (including tangible and electronic chattel paper), deposit
accounts, documents (including negotiable documents), equipment (including all accessions and additions thereto), financial assets, general intangibles (including patents, trademarks, copyrights, goodwill, payment intangibles, domain names and
software), goods (including fixtures), instruments (including promissory notes), inventory (including all goods held for sale or lease or to be furnished under a contract of service, and including returns and repossessions), investment property
(including securities and securities entitlements), letter of credit rights, money, and all of Debtor’s books and records with respect to any of the foregoing, and the computers and equipment containing said books and records; 

(b) any and all cash proceeds and/or noncash proceeds of any of the foregoing, including, without limitation, insurance proceeds, and all
supporting obligations and the security therefor or for any right to payment. All terms above have the meanings given to them in the North Carolina Uniform Commercial Code, as amended or supplemented from time to time, including revised Division 9
of the Uniform Commercial Code-Secured Transactions. 
 Notwithstanding the foregoing, the Collateral shall not include (i) any
property that is nonassignable by its terms without the consent of the licensor thereof or another party (but only to the extent such prohibition on transfer is enforceable under applicable law, including, without limitation, §25-9-406 and §25-9-408 of the Code), (ii) any property where the granting of a
security interest therein is contrary to applicable law, provided that upon the cessation of any such restriction or prohibition, such property shall automatically become part of the Collateral, (iii) any property that constitutes the capital
stock of a controlled foreign corporation (as defined in the IRC), in excess of 65% of the voting power of all classes of capital stock of such controlled foreign corporations entitled to vote, (iv) any property (including any attachments,
accessions or replacements) that is subject to a Lien that is permitted pursuant to clauses (c) or (e) of the definition of Permitted Liens, if the grant of a security interest with respect to such property pursuant to this Agreement would be
prohibited by the agreement creating such Permitted Lien or would otherwise constitute a default thereunder, provided, that such property will be deemed “Collateral” hereunder upon the termination and release of such Permitted Liens or
(v) any property that is Intellectual Property, in any medium, of any kind or nature whatsoever, now or hereafter owned or acquired or received by Borrower, or in which Borrower now holds or hereafter acquires or receives any right or interest;
provided, however, that the Collateral shall include all accounts and general intangibles that consist of rights to payment and proceeds from the sale, licensing or disposition of all or any part, or rights in, the foregoing (the “Rights to
Payment”). 

  
 10 

 Notwithstanding the foregoing, if a judicial authority (including a U.S. Bankruptcy Court)
holds that a security interest in the underlying Intellectual Property is necessary to have a security interest in the Rights to Payment, then the Collateral shall automatically, and effective as of June 8, 2017, include the Intellectual
Property to the extent and only to the extent necessary to permit perfection of Secured Party’s security interest in the Rights to Payment, and further provided, however, that Secured Party’s enforcement rights with respect to any security
interest in the Intellectual Property shall be absolutely limited to the Rights to Payment only, and Secured Party shall have no recourse whatsoever with respect to the underlying Intellectual Property. 

  
 11 

 THIRD AMENDMENT 

TO 
 LOAN AND SECURITY
AGREEMENT 
 This Third Amendment to Loan and Security Agreement (this “Amendment”) is made and entered into
as of September 8, 2017 by and among PACIFIC WESTERN BANK, a California state chartered bank (“Bank”), KALEIDO BIOSCIENCES, INC. and CADENA BIO, INC. (individually and collectively referred to as
“Borrower”). 
 RECITALS 

Borrower and Bank are parties to that certain Loan and Security Agreement dated as of December 21, 2015 (as amended from time to time, the
“Agreement”). The parties desire to amend the Agreement in accordance with the terms of this Amendment. 
 NOW, THEREFORE, the
parties agree as follows; 
  

	1)	 Pursuant to Section 6.2(ii) of the Agreement, Borrower is required to deliver to Bank, within 180 days
after the end of each of Borrower’s fiscal years, annual consolidated and consolidating financial statements for such fiscal year. As agreed by Borrower and Bank, as of the date hereof, Borrower has not delivered to Bank its audited financial
statements for Borrower’s 2016 fiscal year (the “2016 Financials”), as required by the Agreement (the “2016 Financials Deferral”). Bank hereby waives the 2016 Financials Deferral and extends the due date for Borrower to
provide the 2016 Financials to Bank to December 31, 2017. 

  

	2)	 On or about July 21, 2017, Borrower made a principal payment on the Term Loan in the amount of $166,666.66
(such payment, the “July Principal Payment”). On or about August 21, 2017, Borrower made an additional principal payment on the Term Loan in the amount of $166,666.66 (such payment, the “August Principal Payment”). Bank hereby
refunds to Borrower the July Principal Payment and August Principal Payment, Immediately following the processing of the refunds set forth in the foregoing sentence, the outstanding principal under the Term Loan shall be $5,000,000,00.

  

	3)	 Section 2.1(b)(ii) of the Agreement is hereby amended and restated, as follows; 

(ii) Interest shall accrue from the date of each Term Loan at the rate specified in Section 2.3(a), and prior to
September 21, 2017 shall be payable monthly in arrears beginning on the 21st day of the month next following such Term Loan, and continuing on the same day of each month thereafter. Any Term
Loans that are outstanding on September 21, 2017 shall be payable in 27 equal monthly installments of principal, plus all accrued interest, beginning on October 21, 2017 and continuing on the same day of each month thereafter through the Term
Loan Maturity Date, at which time all amounts due in connection with the Term Loans and any other amounts due under this Agreement shall be immediately due and payable. Term Loans, once repaid, may not be reborrowed. Borrower may prepay any Term
Loan in whole or in part at any time without penalty or premium. 

  

	4)	 Unless otherwise defined herein, all initially capitalized terms in this Amendment shall be as defined in the
Agreement. The Agreement, as amended hereby, shall be and remain in full force and effect in accordance with its respective terms and hereby is ratified and confirmed in all respects. Except as expressly set forth herein, the execution, delivery,
and performance of this Amendment shall not operate as a waiver of, or as an amendment of, any right, power, or remedy of Bank under the Agreement, as in effect prior to the date hereof. Each Borrower ratifies and reaffirms the continuing
effectiveness of all agreements entered into in connection with the Agreement. 

  

	5)	 Each Borrower represents and warrants that the representations and warranties contained in the Agreement are
true and correct in all material respects as of the date of this Amendment, provided that any representation or warranty containing a materiality qualifier therein shall be true and collect in all respects. 

 

	6)	 This Amendment may be executed in two or more counterparts, each of which shall be deemed an original, but all
of which together shall constitute one instrument. 

  

	7)	 As a condition to the effectiveness of this Amendment, Bank shall have received, in form and substance
satisfactory to Bank, the following: 

 a) this Amendment, duly executed by each Borrower; 

b) payment of all Bank Expenses incurred through the date of this Amendment, including Bank’s reasonable expenses for the
documentation of this Amendment and any UCC, good standing or intellectual property search or filing fees, which may be debited from any of Borrower’s accounts; and 

c) such other documents and completion of such other matters, as Bank may have reasonably requested. 

[Signature Page Follows] 

  

 IN WITNESS WHEREOF, the undersigned have executed this Amendment as of the first date above written. 

 

									
	KALEIDO BIOSCIENCES, INC.	  	        	  	CADENA BIO, INC.
					
	By:	  	 /s/ Jeffrey Moore
	  		  	By:	  	 /s/ Geoffrey von Maltzahn

	Name:	  	Jeffrey Moore	  		  	Name:	  	Geoffrey von Maltzahn
	Title:	  	SVP, Finance & Administration	  		  	Title:	  	President

  

			
	PACIFIC WESTERN BANK
		
	By:	 	 /s/ Scott Hansen

	Name:	 	Scott Hansen
	Title:	 	SVP

 [Signature Page to Third Amendment to Loan and Security Agreement] 

  

 FOURTH AMENDMENT 

TO 
 LOAN AND SECURITY
AGREEMENT 
 This Fourth Amendment to Loan and Security Agreement (this “Amendment”) is made and entered
into as of October 13, 2017 by and among PACIFIC WESTERN BANK, a California state chartered bank (“Bank”), KALEIDO BIOSCIENCES, INC. and CADENA BIO, INC. (individually or collectively, as the context may require,
“Borrower”). 
 RECITALS 

Borrower and Bank are parties to that certain Loan and Security Agreement dated as of December 21, 2015, as amended by that certain First Amendment to
Loan and Security Agreement, dated as of January 6, 2017, that certain Second Amendment and Joinder to Loan and Security Agreement, dated as of June 8, 2017, and that certain Third Amendment to Loan and Security Agreement, dated as of
September 8, 2017 (as further amended, restated, supplemented or otherwise modified from time to time, the “Agreement”). The parties desire to amend the Agreement in accordance with the terms of this Amendment. 

NOW, THEREFORE, the parties agree as follows: 
  

	1)	 Amendments to Agreement. 

 

	 	a)	 Section 2.1(b) of the Agreement is hereby amended and restated, as follows: 

(b) Term Loan. 

(i) Prior to the Fourth Amendment Date, Borrower has requested and Bank has made, term loans in an aggregate principal
amount of $5,000,000 (the “Existing Term Loan”). As of the Fourth Amendment Date, the aggregate principal amount of Existing Term Loans is $5,000,000. On the Fourth Amendment Date, Borrower shall request and Bank agrees to make a new term
loan in original principal amount of $15,000,000 (the “Term Loan”), which shall be applied to refinance in full the Existing Term Loans, and for general working capital purposes and for capital expenditures. 

(ii) Interest shall accrue from the date of the Term Loan at the rate specified in Section 2.3(a), and prior to
April 13, 2019 shall be payable monthly in arrears beginning on the 13th day of the month, and continuing on the same day of each month thereafter. Any Term Loans that are outstanding on April 13, 2019 shall be payable in 30 equal monthly
installments of principal, plus all accrued interest, beginning on May 13, 2019 and continuing on the same day of each month thereafter through the Term Loan Maturity Date, at which time all amounts due in connection with the Term Loan and any
other amounts due under this Agreement shall be immediately due and payable. The Term Loan, once repaid, may not be reborrowed. 

  
 1 

 (iii) Borrower may prepay all but not less than all of the Term Loan
at any time, provided that Borrower may not reborrow any amount so prepaid, and provided further that upon any prepayment, including any prepayment due to the occurrence of an Event of Default, Borrower shall pay, in addition to all outstanding
principal and accrued interest on the Term Loans, the Prepayment Fee. 
  

	 	b)	 Section 2.3(a) of the Agreement is hereby amended and restated to read as follows: 

(a) Interest Rate. Except as set forth in Section 2.3(b), the Term Loan shall bear interest, on the outstanding
daily balance thereof, at a variable annual rate equal to the greater of (A) 1.50% above the Prime Rate then in effect, or (B) 5.75%. 
  

	 	c)	 Section 2.3(c) of the Agreement is hereby amended and restated to read as follows: 

(c) Payments. Interest under the Term Loans shall be due and payable monthly in arrears on the 13th calendar day of each
month during the term hereof. Bank shall, at its option, charge such interest, fees, all Bank Expenses, and all Periodic Payments against any of Borrower’s deposit accounts, Any interest not paid when due shall be compounded by becoming a part
of the Obligations, and such interest shall thereafter accrue interest at the rate then applicable hereunder 
  

	 	d)	 Section 2.5 of the Agreement is hereby amended and restated to read as follows: 

2.5 Fees. Borrower shall pay to Bank the following: 

(a) Facility Fee. On the Fourth Amendment Date, a facility fee of $25,000, which shall be nonrefundable; 

(b) Prepayment Fee. The Prepayment Fee, when due hereunder. 

(c) Bank Expenses. On the Closing Date, all Bank Expenses incurred through the Closing Date (which have been paid as of
the Fourth Amendment Date), and thereafter, all Bank Expenses as and when they become due. 
  

	 	e)	 Section 6.6 of the Agreement is hereby amended and restated to read as follows: 

6.6 Primary Depository. Borrower shall maintain its primary depository and operating accounts with Bank and its primary investment
accounts with Bank or Bank’s affiliates. Notwithstanding the foregoing, Borrower shall be permitted to (i) maintain payroll and employee benefits accounts at Bank or outside of Bank provided that if the same are outside of Bank, Borrower
must deliver a control agreement in favor of Bank for such accounts, in form and substance satisfactory to Bank in its sole discretion, (ii) maintain Cash and/or Investments in one or more accounts outside of Bank or Bank’s affiliates,
subject to control agreements in favor of Bank, so long as the total aggregate amount of Cash maintained by Borrower in accounts with Bank or Bank’s affiliates equals or exceeds 200% of the sum of (x) the aggregate initial principal amount
of the Term Loans plus (y) the maximum amount of the Credit Card Line, and (iii) transfer Cash and/or 

  
 2 

 
Investments to a Subsidiary that is a “Security Corporation” as defined in 830 Code of Mass. Regulations 63.38B.1 (as the same may be amended, modified or supplemented from time to
time) to be held in one or more accounts outside of Bank or Bank’s affiliates, without the requirement for control agreements, so long as the total aggregate amount of Cash maintained by Borrower in all accounts maintained by Borrower with Bank
or Bank’s affiliates equals or exceeds 120% of the aggregate principal amount of Credit Extensions then outstanding. Prior to maintaining any investment accounts with Bank’s affiliates, Borrower, Bank, and any such affiliate shall have
entered into a securities account control agreement with respect to any such investment accounts, in form and substance satisfactory to Bank. 
  

	 	f)	 Section 7.11 of the Agreement is hereby amended and restated to read as follows: 

7.11 Inventory and Equipment. Store the Inventory or the Equipment of a book value in excess of $250,000 with a bailee,
warehouseman, collocation facility or similar third party unless the third party has been notified of Bank’s security interest and Bank (a) has received an acknowledgment from the third party that it is holding or will hold the Inventory
or Equipment for Bank’s benefit or (b) is in possession of the warehouse receipt, where negotiable, covering such Inventory or Equipment. Except for Inventory sold in the ordinary course of business and for movable items of personal
property having an aggregate book value not in excess of $250,000, and except for such other locations as Bank may approve in writing, Borrower shall keep the Inventory and Equipment only at the location set forth in Section 10 of the Schedule,
and such other locations of which Borrower gives Bank prior written notice and as to which Bank is able to take such actions as may be reasonably necessary to perfect its security interest or to obtain a bailee’s acknowledgment of Bank’s
rights in the Collateral. Notwithstanding the foregoing, Borrower may maintain (i) clinical study materials with contract manufacturing organization for production or processing and at clinical sites, including outside the United States, and
(ii) Equipment with a book value not in excess of $1,500,000 used in production by contract manufacturing organization, including outside the United States, and shall not be required to obtain a bailee waiver or similar third party agreement
with respect to such Collateral or obtain Bank’s approval for the location where such Collateral shall be located. 
  

	 	g)	 Exhibit A of the Agreement is hereby amended to amend or add the definitions set forth below in appropriate
alphabetical order, as applicable: 

 “Credit Extension” means the Term Loan, the Credit Card Services provided
under the Credit Card Line, or any other extension of credit by Bank to or for the benefit of Borrower hereunder. 
 “Fourth Amendment
Date” means October 13, 2017. 

  
 3 

 “Obligations” means all debt, principal, interest, fees, Bank Expenses and other
amounts owed to Bank by Borrower pursuant to this Agreement or any other agreement (other than any warrant or equity related agreement), whether absolute or contingent, due or to become due, now existing or hereafter arising, including any interest
that accrues after the commencement of an Insolvency Proceeding and including any debt, liability, or obligation owing from Borrower to others that Bank may have obtained by assignment or otherwise. 

“Prepayment Fee” means a fee in an amount equal to (i) 1.5% of the principal amount prepaid, with respect to a prepayment made on or
prior to the one year anniversary of the Fourth Amendment Date, and (ii) 0.5% of the principal amount prepaid, with respect to a prepayment made after the one year anniversary of the Fourth Amendment Date through the two year anniversary of the
Fourth Amendment Date, provided that after the two year anniversary of the Fourth Amendment Date, the Prepayment Fee shall be zero. 

“Term Loan Maturity Date” means October 13, 2021. 
  

	 	h)	 The defined term “Permitted Indebtedness” set forth in Exhibit A of this Agreement, is hereby amended
to delete “and” at the end of clause (i), replace “.” At the end of clause (j) with “; and”, and add a new clause (k), to read as follows: 

(k) Indebtedness in an aggregate amount not to exceed $ 104,000, arising under a letter of credit issued by Silicon Valley Bank. 

 

	 	i)	 The defined term “Permitted Liens” set forth in Exhibit A of this Agreement, is hereby amended to
delete “and” at the end of clause (j), replace “.” At the end of clause (k) with “; and”, and add a new clause (m), to read as follows: 

(m) Liens on cash collateral in an aggregate amount not to exceed $104,000, securing Indebtedness described in clause (k) of the defined
term “Permitted Indebtedness”. 
  

	 	j)	 Exhibit A of the Agreement is hereby amended to delete the following defined terms and related definitions:
“Availability End Date”, “Tranche”, “Tranche A”, “Tranche B”, and “Tranche B Milestones”. 

  

	 	k)	 The Schedule attached to the Agreement is hereby amended and restated as set forth in the Schedule attached
hereto. 

  

	2)	 Unless otherwise defined, all initially capitalized terms in this Amendment shall be as defined in the
Agreement. The Agreement, as amended hereby, shall be and remain in full force and effect in accordance with its respective terms and hereby is ratified and confirmed in all respects. Except as expressly set forth herein, the execution, delivery,
and performance of this Amendment shall not operate as a waiver of, or as an amendment of, any right, power, or remedy of Bank under the Agreement, as in effect prior to the date hereof. Each Borrower ratifies and reaffirms the continuing
effectiveness of all agreements entered into in connection with the Agreement. 

  

	3)	 Each Borrower represents and warrants that the representations and warranties of Borrower contained in the
Agreement are true and correct in all material respects as of the date of this Amendment, provided that with respect to Borrower’s registered Intellectual Property, Schedule 5.4 reflects Borrower’s registered Intellectual Property as of
the Fourth Amendment Date. 

  
 4 

	4)	 This Amendment may be executed in two or more counterparts, each of which shall be deemed an original, but all
of which together shall constitute one instrument. 

  

	5)	 The provisions of Sections 11 and 12 are hereby incorporated herein, provided that all references to the
“Agreement”, shall mean the Agreement, as amended by this Amendment. 

  

	6)	 As a condition to the effectiveness of this Amendment, Bank shall have received, in form and substance
satisfactory to Bank, the following: 

 a) this Amendment, duly executed by Borrower; 

b) the amendment to warrant, and a warrant to purchase stock, duly executed by Borrower; 

c) an officer’s certificate of Borrower with respect to incumbency and resolutions authorizing the execution and delivery
of this Amendment; 
 d) delivery of the Loan Advance/Paydown Request From in accordance with Section 2.1 and
satisfaction of all other conditions set forth in Section 3.2; 
 e) current SOS Reports indicating that except for
Permitted Liens, there are no other security interests or Liens of record in the Collateral; 
 f) payment of the facility
fee in accordance with Section 2.5 of the Agreement, as amended hereby, and all Bank Expenses incurred through the date of this Amendment, including Bank’s reasonable expenses for the documentation of this Amendment and any UCC, good
standing or intellectual property search or filing fees, which may be debited from any of Borrower’s accounts; and 
 g)
such other documents and completion of such other matters, as Bank may have reasonably requested. 
  

	7)	 Borrower agrees to provide evidence of the termination or amendment to exclude intellectual property purchased
by Borrower of the following UCC financing statements filed against Flagship Ventures Management, Inc.: filing #20133643260, filed with the Delaware Secretary of State. 

[Signature Page Follows] 

  
 5 

 IN WITNESS WHEREOF, the undersigned have executed this Amendment as of the first date above written. 

 

							
	KALEIDO BIOSCIENCES, INC.	 	CADENA BIO, INC.
				
	By:	 	 /s/ Jeffrey Moore
	 	By:	 	 /s/ Jeffrey Moore

	Name:	 	Jeffrey Moore	 	Name:	 	Jeffrey Moore
	Title:	 	SVP, Finance & Administration, Treasurer & Secretary	 	Title:	 	Treasurer & Secretary

  

			
	PACIFIC WESTERN BANK
		
	By:	 	 /s/ Scott Hansen

	Name:	 	Scott Hansen
	Title:	 	SVP

 [Signature Page to Fourth Amendment to Loan and Security Agreement] 

  
 6 

 SCHEDULE 

Schedule 5.4  
 Patents: 

U.S. 8,466,242, Polymeric Acid Catalysts and Uses Thereof 
 U.S.
8,476,388, Polymeric Acid Catalysts and Uses Thereof 
 U.S. 9,079,171, Polymeric Acid Catalysts and Uses Thereof 

U.S. 9,205,418, Polymeric Acid Catalysts and Uses Thereof 
 U.S.
9,238,845, Methods of Producing Sugars from Biomass Feedstocks 
 U.S. 9,492,473, Glycan Therapeutics and Related Methods Thereof 

U.S. 9,757,403, Glycan Therapeutics and Related Methods Thereof 

AU 2012223494, Polymeric Acid Catalysts and Uses Thereof 
 MX
344405, Polymeric Acid Catalysts and Uses Thereof 
 NZ 616047, Polymeric Acid Catalysts and Uses Thereof 

SG 192958, Polymeric Acid Catalysts and Uses Thereof 
 CN
ZL201380055050.3, Polymeric and Solid-Supported Catalysts, and Methods of Digesting Cellulosic Materials Using such Catalysts 
 Patent Applications:

  

									
	 Application No.
	  	 Country
	  	 Status
	  	 Filing Date
	  	 Application Title

	2016212030	  	AU	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	1120170156148	  	BR	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	2973617	  	CA	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	201701901	  	CL	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
		  	CN	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
		  	EA	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

  
 7 

									
	 Application No.
	  	 Country
	  	 Status
	  	 Filing Date
	  	 Application Title

	 16704085.6
	  	 EP
	  	 Pending
	  	 13-Jan-2016
	  	GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF
					
	17102650.8	  	HK	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	PID201704900	  	ID	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	253195	  	IL	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	201717026559	  	IN	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
		  	JP	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	10-2017-7023785	  	KR	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	MX/a/2017/009589	  	MX	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	PI2017001075	  	MY	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	733270	  	NZ	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	1-2017-501342	  	PH	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	11201706033X	  	SG	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	62/152005	  	US	  	Expired	  	23-Apr-2015	  	GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR METABOLIC DISEASES
					
	62/216993	  	US	  	Expired	  	10-Sep-2015	  	GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR METABOLIC DISEASES
					
	15/017396	  	US	  	Granted	  	05-Feb-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

  
 8 

									
	 Application No.
	  	 Country
	  	 Status
	  	 Filing Date
	  	 Application Title

	15/286382	  	US	  	Published	  	05-Oct-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	15/385331	  	US	  	Granted	  	20-Dec-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	15/374511	  	US	  	Published	  	09-Dec-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	15/624372	  	US	  	Pending	  	15-Jun-2017	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	PCT/US2016/013305	  	WO	  	Inactive	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
	2017/04735	  	ZA	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
					
		  	AU	  	Pending	  	23-Apr-2016	  	GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF
					
		  	JP	  	Pending	  	23-Apr-2016	  	GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF
					
		  	NZ	  	Pending	  	23-Apr-2016	  	GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF
					
	62/152007	  	US	  	Expired	  	23-Apr-2015	  	GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR INFLAMMATORY DISEASES
					
	62/216995	  	US	  	Expired	  	10-Sep-2015	  	GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR INFLAMMATORY DISEASES
					
	PCT/US2016/029070	  	WO	  	Abandoned	  	22-Apr-2016	  	GLYCAN THERAPEUTICS AND METHODS OF TREATMENT
					
	PCT/US2016/029082	  	WO	  	Published	  	23-Apr-2016	  	GLYCAN THERAPEUTICS AND METHODS OF TREATMENT

  
 9 

									
	 Application No.
	  	 Country
	  	 Status
	  	 Filing Date
	  	 Application Title

		  	AU	  	Pending	  	23-Apr-2016	  	MICROBIOME REGULATORS AND RELATED USES THEREOF
					
		  	IN	  	Pending	  	23-Apr-2016	  	MICROBIOME REGULATORS AND RELATED USES THEREOF
					
		  	JP	  	Pending	  	23-Apr-2016	  	MICROBIOME REGULATORS AND RELATED USES THEREOF
					
		  	NZ	  	Pending	  	23-Apr-2016	  	MICROBIOME REGULATORS AND RELATED USES THEREOF
					
		  	SG	  	Pending	  	23-Apr-2016	  	MICROBIOME REGULATORS AND RELATED USES THEREOF
					
	62/152011	  	US	  	Expired	  	23-Apr-2015	  	GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR INFECTIOUS DISEASES
					
	62/216997	  	US	  	Expired	  	10-Sep-2015	  	GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR INFECTIOUS DISEASES
					
	PCT/US2016/029065	  	WO	  	Abandoned	  	22-Apr-2016	  	MICROBIOME REGULATORS AND RELATED USES THEREOF
					
	PCT/US2016/029083	  	WO	  	Published	  	23-Apr-2016	  	MICROBIOME REGULATORS AND RELATED USES THEREOF
					
		  	ZA	  	Pending	  	23-Apr-2016	  	MICROBIOME REGULATORS AND RELATED USES THEREOF
					
	62/152016	  	US	  	Expired	  	23-Apr-2015	  	GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR MICROBIOME DISEASES
					
	62/217002	  	US	  	Expired	  	10-Sep-2015	  	GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR MICROBIOME DISEASES
					
	62/152017	  	US	  	Expired	  	23-Apr-2015	  	HYBRID GLYCAN STRUCTURES, THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR ALTERING THE MICROBIOTA

  
 10 

									
	 Application No.
	  	 Country
	  	 Status
	  	 Filing Date
	  	 Application Title

	62/209615	  	US	  	Expired	  	25-Aug-2015	  	GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF OF THE MODULATION OF SKIN MICROBIOTA
					
	62/209618	  	US	  	Expired	  	25-Aug-2015	  	GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR THE MODULATION OF VAGINAL MICROBIOTA
					
	PCT/US2016/048794	  	WO	  	Published	  	25-Aug-2016	  	GLYCAN COMPOSITIONS AND USES THEREOF
					
	62/209626	  	US	  	Expired	  	25-Aug-2015	  	GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR THE MODULATION OF ORAL MICROBIOTA
					
	62/209629	  	US	  	Expired	  	25-Aug-2015	  	GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR THE MODULATION OF NASAL MICROBIOTA
					
	62/238110	  	US	  	Expired	  	06-Oct-2015	  	GLYCAN THERAPEUTICS COMPRISING POLYPHENOLS AND USES THEREOF IN INFECTIOUS AND INFLAMMATORY DISEASES
					
	62/238112	  	US	  	Expired	  	06-Oct-2015	  	GLYCAN THERAPEUTICS COMPRISING POLYPHENOLS AND USES THEREOF IN METABOLIC AND MICROBIOME-ASSOCIATED DISEASES
					
	62/255365	  	US	  	Expired	  	13-Nov-2015	  	MICROBIOME REGULATORS AND USES THEREOF IN INFECTIOUS AND INFLAMMATORY DISEASES
					
	62/255366	  	US	  	Expired	  	13-Nov-2015	  	MICROBIOME REGULATORS AND USES THEREOF IN MICROBIOME AND METABOLIC DISEASES
					
	62/108039	  	US	  	Expired	  	26-Jan-2015	  	METHODS OF TREATING METABOLIC DISORDERS USING OLIGOSACCHARIDE COMPOSITIONS

  
 11 

									
	 Application No.
	  	 Country
	  	 Status
	  	 Filing Date
	  	 Application Title

	62/278333	  	US	  	Expired	  	13-Jan-2016	  	METHODS OF TREATING CANCER
					
	62/361998	  	US	  	Expired	  	13-Jul-2016	  	GLYCAN COMPOSITIONS AND METHODS OF USE
					
	PCT/US2017/042022	  	WO	  	Pending	  	13-Jul-2017	  	GLYCAN COMPOSITIONS AND METHODS OF USE
					
	62/362025	  	US	  	Expired	  	13-Jul-2016	  	GLYCAN PREPARATIONS AND METHODS OF TREATMENT
					
	62/367472	  	US	  	Expired	  	27-Jul-2016	  	GLYCAN PREPARATIONS AND METHODS OF TREATMENT
					
	62/379677	  	US	  	Abandoned	  	25-Aug-2016	  	GLYCAN PREPARATIONS AND METHODS OF TREATMENT
					
	62/435052	  	US	  	Abandoned	  	15-Dec-2016	  	GLYCAN PREPARATIONS AND METHODS OF TREATMENT
					
	62/367616	  	US	  	Inactive	  	27-Jul-2016	  	GLYCAN THERAPEUTICS AND VARIATIONS THEREOF
					
	62/379676	  	US	  	Abandoned	  	25-Aug-2016	  	GLYCAN THERAPEUTICS AND VARIATIONS THEREOF
					
	62/430895	  	US	  	Pending	  	06-Dec-2016	  	GLYCAN POLYMERS AND RELATED METHODS THEREOF
					
	62/446316	  	US	  	Pending	  	13-Jan-2017	  	GLYCAN POLYMERS AND RELATED METHODS THEREOF
					
	62/430849	  	US	  	Pending	  	06-Dec-2016	  	GLYCAN POLYMERS AND METHODS OF SYNTHESIS THEREOF

  
 12 

									
	 Title/Inventors
	  	 Pub. No.

Serial No.
	  	 Status
	  	 Patent No.
	  	 Issue Date

	POLYMERIC ACID CATALYSTS AND USES THEREOF	  	 U.S.S.N. 13/406,490
  

Filed 2/27/2012
  
	  	Granted	  	9,079,171	  	7/14/2015
	  	U.S.S.N. 13/406,517	  	Granted	  	8,466,242	  	6/18/2013
					
		  	Filed 2/27/2012	  		  		  	
					
	 John M. Geremia
  

Brian M. Baynes
  
	  	 U.S.S.N. 13/657,724
  

Filed 10/22/2012
	  	Granted	  	8,476,388	  	7/2/2013
					
	Ashish Dhawan	  	 U.S.S.N. 13/865,048
  

Filed 4/17/2013
	  	Granted	  	9,205,418	  	12/8/2015
					
	 Corresponding to International Application PCT/US2012/026820 filed 2/27/2012

 
	  	 U.S.S.N. 14/730,143*
  

Filed 6/3/2015
	  	Pending	  		  	
					
	 Priority information:
  

61/447,311 filed 2/28/2011
  

61/522,351 filed 8/11/2011
	  	 AR P20120100642
  

Filed 2/28/2012
  
	  	Pending	  		  	
	  	 AU 2012223494
  
	  	Granted	  	2012223494	  	07/20/2017
	  	BR1120130220473	  	Pending	  		  	
					
		  	CA 2,864,086	  	Pending	  		  	
					
		  	CL 2463-2013	  	Abandoned	  		  	
					
		  	CN 201280018901.2	  	Pending	  		  	
					
		  	CO 13230542	  	Allowed	  		  	
					
		  	EP 12709207.0	  	Pending	  		  	
					
		  	ID W00201304395	  	Pending	  		  	
					
		  	IN 7946/DELNP/2013	  	Pending	  		  	
					
		  	JM 18/1/5278	  	Pending	  		  	
					
		  	KR 10-2013-7018658	  	Abandoned	  		  	
					
		  	MX/a/2013/009920	  	Granted	  	 344405
 (associate returned to the patent office
for correction)
	  	TBD
					
		  	MX/a/2015/016430	  	Pending	  		  	
					
		  	MY PI 2013003157	  	Abandoned	  		  	
					
		  	NZ 616047	  	Granted	  	616047	  	3/30/2016
					
		  	PH 1-2013-501775	  	Pending	  		  	
					
		  	RU 2013143822  	  	Abandoned	  		  	
					
		  	 SG 201306465-4
  
	  	Granted	  	192958	  	3/9/2016
	  	 TH 1301004754
  
	  	Pending	  		  	
	  	ZA 2013/06233	  	Pending	  		  	

  
 13 

									
	 Title/Inventors
	  	 Pub. No.

Serial No.
	  	 Status
	  	 Patent No.
	  	 Issue Date

	 METHODS OF PRODUCING SUGARS FROM BIOMASS FEEDSTOCKS
  

Brian M. Baynes
  

John M. Geremia
  

Joseph Andoh
  

Ashish Dhawan
  

Priority information:
  

61/693,210 filed 8/24/2012
	  	 U.S.S.N. 13/831,495
  

Filed 3/14/2013
	  	Granted	  	9,238,845	  	1/19/2016
					
	 POLYMERIC AND SOLID- SUPPORTED CATALYSTS, AND METHODS OF DIGESTING CELLULOSIC MATERIALS USING SUCH CATALYSTS

 
 John M. Geremia

 
 Brian M. Baynes

 
 Jaouad Fichtali

 
 Joseph Andoh
  

Corresponding to International Application No. PCT/US2013/056389 filed 8/23/2013
  

Priority information:
  

61/693,200 filed 8/24/2012
  

61/693,210 filed 8/24/2012
  

61/693,213 filed 8/24/2012
	  	 U.S.S.N. 14/423,697*
  

Filed 2/24/2015
  

CA 2,922,254
  

CN 201380055050.3
  

EP 13831228.5
  

KR 10-2015-7007481
  
	  	 Abandoned
  

 
 Pending
  

Granted
  

Pending
  

Pending
	  	  
 ZL201380055050.3
	  	  

4/12/2017

  
 14 

									
	 Title/Inventors
	  	 Pub. No.

Serial No.
	  	 Status
	  	 Patent No.
	  	 Issue Date

	 POLYMERIC AND SOLID- SUPPORTED CATALYSTS, AND METHODS OF DIGESTING LIGNIN- CONTAINING MATERIALS USING SUCH CATALYSTS

 
 John M. Geremia

 
 Corresponding to International Application No.

PCT/US2013/056462 filed 8/23/2013
  

Priority information:
  

61/693,216 filed 8/24/2012
	  	 U.S.S.N. 14/423,698*
  

Filed 2/24/2015
  

EP 13830609.7
	  	 Abandoned
  

 
 Abandoned

 
	  		  	
					
	 POLYMERIC IONIC SALT CATALYSTS AND METHODS OF PRODUCING THEREOF
  

Brian M. Baynes
  

John M. Geremia
  

Joseph Andoh
  

Corresponding to International Application No.
 PCT/US2014/024177
filed 3/12/2014
  
 Priority information:

 
 61/786,230 filed 3/14/2013
	  	 U.S.S.N. 14/776,490*
  

Filed 9/14/2015
  

AU 2014240435
  

BR1120150233260
  

CA 2,903,232
  

CL 2812-2015
  

CN 2014800279677
  

EA 201591749
  

EP 14773809.0
  

IL 241011
  

IN 9479/DELNP/2015
  

JP 2016-501432
  

KR 10-2015-7029201
  

MX/a/2015/012436
  

NZ 711537
  

SG 11201507229Q
  

ZA 2015/06716
	  	 Abandoned
  

 
 Abandoned
  

Abandoned
  

Pending
  

Abandoned
  

Abandoned
  

Abandoned
  

Abandoned
  

Abandoned
  

Abandoned
  

Abandoned
  

Pending
  

Pending
  

Pending
  

Abandoned
  

Abandoned
  
	  		  	

  
 15 

									
	 Title/Inventors
	  	 Pub. No.

Serial No.
	  	 Status
	  	 Patent No.
	  	 Issue Date

	 METHODS FOR PRODUCING OLIGOSACCHARIDES
  

John M. Geremia
  

Scott Han
  

Alicia Landry
  

Kyle Sherry
  

Stephan Panos
  

Corresponding to International
 Application No.

PCT/US2015/039795 filed 7/9/2015
  

Priority information:
  

62/022,579 filed 7/9/2014
  

62/108,035 filed 1/26/2015
	  	 U.S.S.N. 14/795,720*
  

Filed 7/9/2015
  

2015287703
  

BR112017000345-7
  

CA 2,954,662
  

201580048065.6
  

15819734.3
  

P00 2017 00913
  

249982
  

201717004105
  

2017-522455
  

MX/a/2017/000319
  

PI 2017000019
	  	 Pending
  

 
 Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
	  		  	
					
	 OLIGOSACCHARIDE COMPOSITIONS FOR USE AS FOOD INGREDIENTS AND METHODS OF PRODUCING THEREOF

 
 John M. Geremia

 
 Raffi Mardirosian

 
 Michael J. Gidding

 
 Corresponding to International Application PCT/US2016/013265 filed January 13,
2016
  
 Priority information:

 
 62/108,036 filed 1/26/2015
	  	 U.S.S.N. 15/546,438
  

Filed 7/26/2017
  

AU 2016212025
  

BR 1120170159465
  

CA 2,975,091
  

CN Not Yet Assigned
  

EP 16743841.5
  

ID PID201705111
  

IN 201717028052
  

JP Not Yet Assigned
  

MX/a/2017/009722
  

MY PI 2017001086
  

PH 1-2017-501341
  

RU 2017130166
  

ZA 2017/05200  
  
	  	 Pending
  

 
 Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
	  		  	

  
 16 

									
	 Title/Inventors
	  	 Pub. No.

Serial No.
	  	 Status
	  	 Patent No.
	  	 Issue Date

	 OLIGOSACCHARIDE COMPOSITIONS FOR USE IN NUTRITIONAL COMPOSITIONS, AND METHODS OF PRODUCING THEREOF

 
 John M. Geremia

 
 Corresponding to International Application PCT/US2016/013271

 
 Filed January 13, 2016

 
 Priority information:

 
 62/108,038 filed 1/26/2015

 
	  	 U.S.S.N 15/546,508
 filed 07/26/2017

 
 AU 2016212026
  

CA 2,975,093
  

CN Not Yet Assigned
  

EP 16743842.3
  

JP Not Yet Assigned
  

MX/a/2017/009720
  
	  	 Pending
  

 
 Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
  
	  		  	
	 METHODS OF PRODUCING ANHYDROSUGAR ALCOHOLS
  

John M. Geremia
  

Priority information:
  

U.S.S.N. 62/108,460 filed 1/27/2015
	  	 PCT/US2016/014109
  

Filed 1/20/2016
	  	Expired	  		  	
					
	OLIGOSACCHARIDE COMPOSITIONS FOR USE AS ANIMAL FEED AND METHODS OF PRODUCING THEREOF	  	 U.S.S.N. 14/995,129
  

Filed 1/13/2016
  

BR 1120170159449
	  	 Pending
  

 
 Pending
	  		  	

  
 17 

									
	 Title/Inventors
	  	 Pub. No.

Serial No.
	  	 Status
	  	 Patent No.
	  	 Issue Date

	 John M. Geremia
  

Raffi Mardirosian
  

Michael J. Gidding
  

Anastasia V. Murphy
  

Corresponding to PCT/US2016/013280
  

Filed 1/13/2016
  

Priority information:
  

62/108,037 filed 1/26/2015
  

62/216,945 filed 9/10/2015
  

62/216,952 filed 9/10/2015
  

62/255,341 filed 11/13/2015
  

62/255,343 filed 11/13/2015
	  	 CA 2,975,095
  

CN Not Yet Assigned
  

EP 16743843.1
  

IN 201717026993
  

JP Not Yet Assigned
  

MX/a/2017/009730
	  	 Pending
  

Pending
  

Pending
  

Pending
  

Pending
  

Pending
	  		  	
					
	 ANIMAL Therapeutic and feed compositions and methods of use
  

John M. Geremia
  

Anastasia V. Murphy
  

Priority information:
  

62/255,348 filed 11/13/2015
  

62/255,352 filed 11/13/2015
	  	 PCT/US2016/061337
  

Filed 11/10/2016
	  	Pending	  		  	

 Trademark and/or Service marks 

The following marks have been applied for but not yet granted. 

  
 18 

											
	 App No.
	  	 Mark
	  	 Country
	  	 Filing Date
	  	 Status
	  	 Oppositions

	1776706	  	KALEIDO	  	Canada	  	11-Apr-2016	  	Pending	  	
						
	1314387	  	KALEIDO	  	Int’l Registration-Madrid Protocol designating: Japan, China, European Union, Mexico	  	08-Apr-2016	  	Registered	  	 OPPOSITION NO. B 002849142: MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. of the KALEIDO mark based on Menarini’s prior rights in
KALEIDON (EUTM No. 004712998) for “pharmaceutical and veterinary preparations; sanitary
 preparations for medical purposes; dietetic substances adapted
for medical use, food for babies” in Class 5

						
	86/783357	  	KALEIDO	  	United States of America	  	09-Oct-2015	  	Pending	  	
						
	87/195340	  	MICROBIOM E ENHANCER	  	United States of America	  	06-Oct-2016	  	Pending	  	

  
 19 

									
	 Application No.
	  	 Mark
	  	 Country
	  	 Filing Date
	  	 Status

	A0066335	  	CADENABIO	  	International Application (Madrid Protocol designating AU, CN, EM, IN, JP, MX)	  	13-Apr-2017	  	Pending
					
	87/203,406	  	CADENABIO	  	United States	  	14-Oct-2016	  	Pending
					
	912585048	  	CADENABIO	  	Brazil	  	13-Apr-2017	  	Pending
					
	1,831,930	  	CADENABIO	  	Canada	  	10-Apr-2017	  	Pending
					
	87/203,415	  	OPTIBIOME	  	United States	  	14-Oct-2016	  	Abandoned
					
	87/244,879	  	BIOMESSENTIALS	  	United States	  	22-Nov-2016	  	Abandoned
					
	A0067115	  	BIOMESSENTIALS	  	International Application (Madrid Protocol designating AU, CN, EM, IN, JP, MX)	  	17-May-2017	  	Pending
					
	87/318,742	  	BIOMESSENTIALS	  	United States	  	31-Jan-2017	  	Pending
					
	912756225	  	BIOMESSENTIALS	  	Brazil	  	22-May-2017	  	Pending
					
	1,838,164	  	BIOMESSENTIALS	  	Canada	  	17-May-2017	  	Pending

  
 20 

 FIFTH AMENDMENT 

TO 
 LOAN AND SECURITY
AGREEMENT 
 This Fifth Amendment to Loan and Security Agreement (this “Amendment”) is made and entered into
as of June 22, 2018 by and among PACIFIC WESTERN BANK, a California state chartered bank (“Bank”), KALEIDO BIOSCIENCES, INC. and CADENA BIO, INC. (individually or collectively, as the context may require,
“Borrower”). 
 RECITALS 

Borrower and Bank are parties to that certain Loan and Security Agreement dated as of December 21, 2015, as amended by that certain First
Amendment to Loan and Security Agreement, dated as of January 6, 2017, that certain Second Amendment and Joinder to Loan and Security Agreement, dated as of June 8, 2017, that certain Third Amendment to Loan and Security Agreement, dated as of
September 8, 2017, that certain Fourth Amendment dated October 13, 2017, that certain letter agreement dated as of December 11, 2017 and that certain letter agreement dated as of March 29, 2018 (as further amended, restated, supplemented or
otherwise modified from time to time, the “Agreement”). The parties desire to amend the Agreement in accordance with the terms of this Amendment. 

NOW, THEREFORE, the parties agree as follows: 
  

	1)	 Amendments to Agreement. 

 

	 	a)	 Section 2.1(b)(ii) of the Agreement is hereby amended and restated, as follows: 

(ii) Interest shall accrue from the date of the Term Loan at the rate specified in Section 2.3(a), and prior to
April 13, 2020 shall be payable monthly in arrears beginning on the 13th day of the month, and continuing on the same day of each month thereafter. Any Term Loans that are outstanding on April 13, 2020 shall be payable in 24 equal monthly
installments of principal, plus all accrued interest, beginning on May 13, 2020 and continuing on the same day of each month thereafter through the Term Loan Maturity Date, at which time all amounts due in connection with the Term Loan and any
other amounts due under this Agreement shall be immediately due and payable. The Term Loan, once repaid, may not be reborrowed. 
  

	 	b)	 Section 2.3(a) of the Agreement is hereby amended and restated, as follows: 

(a) Interest Rate. Except as set forth in Section 2.3(b), the Term Loan shall bear interest, on the outstanding
daily balance thereof, at a variable annual rate equal to the greater of (A) 1.00% above the Prime Rate then in effect, or (B) 5.25%. 

	 	c)	 Section 2.5(a) of the Agreement is hereby amended and restated to read as follows: 

(a) Facility Fee. On the Fourth Amendment Date, a facility fee of $25,000, which shall be nonrefundable, and on the
Fifth Amendment Date, a facility fee of $25,000, which shall be nonrefundable. 
  

	 	d)	 A new Section 2.5(d) is hereby added to the Agreement in appropriate order to read as follows:

 (d) Success Fee. Upon a Liquidity Event, a success fee of $300,000. This Section 2.5(d)
shall survive the termination of this Agreement. 
  

	 	e)	 Exhibit A of the Agreement is hereby amended to amend or add the definitions set forth below in
appropriate alphabetical order, as applicable: 

 “Credit Card Line” means a Credit Extension of up to $250,000,
to be used exclusively for the provision of Credit Card Services. 
 “Credit Card Maturity Date” means the 364th days after the
Fifth Amendment Date. 
 “Fifth Amendment Date” means June 22, 2018. 

“Liquidity Event” means (a) any sale, license, or other disposition of all or substantially all of the assets (including
intellectual property) of Borrower, (b) any reorganization, consolidation, merger or sale of the voting securities of Borrower or any other transaction where the holders of Borrower’s securities before the transaction beneficially own less
than 50% of the outstanding voting securities of the surviving entity after the transaction, or (c) an initial public offering of Borrower’s equity securities, in each case, which is consummated at any time prior to the tenth anniversary
of the Fifth Amendment Date. 
 “Prepayment Fee” means a fee in an amount equal to (i) 1.5% of the principal amount prepaid, with
respect to a prepayment made on or prior to the one year anniversary of the Fifth Amendment Date, and (ii) 0.5% of the principal amount prepaid, with respect to a prepayment made after the one year anniversary of the Fifth Amendment Date through the
two year anniversary of the Fifth Amendment Date, provided that after the two year anniversary of the Fifth Amendment Date, the Prepayment Fee shall be zero. 

“Term Loan Maturity Date” means April 13, 2022. 
  

	 	2)	 Unless otherwise defined, all initially capitalized terms in this Amendment shall be as defined in the
Agreement. The Agreement, as amended hereby, shall be and remain in full force and effect in accordance with its respective terms and hereby is ratified and confirmed in all respects. Except as expressly set forth herein, the execution, delivery,
and performance of this Amendment shall not operate as a waiver of, or as an amendment of, any right, power, or remedy of Bank under the Agreement, as in effect prior to the date hereof. Each Borrower ratifies and reaffirms the continuing
effectiveness of all agreements entered into in connection with the Agreement. 

  

	 	3)	 Each Borrower represents and warrants that the representations and warranties of Borrower contained in the
Agreement are true and correct in all material respects as of the date of this Amendment, provided that with respect to Borrowers’ registered Intellectual Property, the Schedule attached hereto reflects Borrower’s registered Intellectual
Property as of the Fifth Amendment Date. 

  
 2 

	 	4)	 This Amendment may be executed in two or more counterparts, each of which shall be deemed an original, but all
of which together shall constitute one instrument. 

  

	 	5)	 The provisions of Sections 11 and 12 of the Agreement are hereby incorporated herein, provided that all
references to the “Agreement”, shall mean the Agreement, as amended by this Amendment. 

  

	 	6)	 As a condition to the effectiveness of this Amendment, Bank shall have received, in form and substance
satisfactory to Bank, the following: 

 a) this Amendment, duly executed by Borrower; 

b) an officer’s certificate of Borrower with respect to incumbency and resolutions authorizing the execution and delivery
of this Amendment; 
 c) payment of the facility fee in accordance with Section 2.5 of the Agreement, as amended hereby,
which is due on the Fifth Amendment Date, and all Bank Expenses incurred through the Fifth Amendment Date, including Bank’s reasonable expenses for the documentation of this Amendment, which may be debited from any of Borrower’s accounts;
and 
 d) such other documents and completion of such other matters, as Bank may have reasonably requested. 

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 

  
 3 

 [SIGNATURE PAGE TO FIFTH AMENDMENT TO LOAN AND SECURITY AGREEMENT] 

IN WITNESS WHEREOF, the undersigned have executed this Amendment as of the first date above written. 

 

									
	KALEIDO BIOSCIENCES, INC.	  		  	CADENA BIO, INC.
					
	By:	 	 /s/ Joshua Brumm
	  	:	  	By:	  	 /s/ Michael Bonney

	Name:	 	Joshua Brumm	  		  	Name:	  	Michael Bonney
	Title:	 	CFO	  		  	Title:	  	Sales Director & President

  

			
	PACIFIC WESTERN BANK
		
	By:	 	 /s/ Scott Hansen

	Name:	 	Scott Hansen
	Title:	 	SVP

  
 4 

 SCHEDULE 
  

	 	I)	 Cadena IP Assets: 

Patents: 
 U.S. 8,466,242, Polymeric Acid Catalysts and
Uses Thereof 
 U.S. 8,476,388, Polymeric Acid Catalysts and Uses Thereof 

U.S. 9,079,171, Polymeric Acid Catalysts and Uses Thereof 
 U.S.
9,205,418, Polymeric Acid Catalysts and Uses Thereof 
 U.S. 9,238,845, Methods of Producing Sugars from Biomass Feedstocks 

EP 2681547, Polymeric Acid Catalysts and Uses Thereof 
 AU
2012223494, Polymeric Acid Catalysts and Uses Thereof 
 CO 30876, Polymeric Acid Catalysts and Uses Thereof 

ID 465560, Polymeric Acid Catalysts and Uses Thereof 
 MX
344405, Polymeric Acid Catalysts and Uses Thereof 
 NZ 616047, Polymeric Acid Catalysts and Uses Thereof 

SG 192958, Polymeric Acid Catalysts and Uses Thereof 
 CN
ZL201380055050.3, Polymeric and Solid-Supported Catalysts, and Methods of Digesting Cellulosic Materials Using such Catalysts 
 Patents and
Applications: 
  

																			
	 	 	 Title/Inventors
	 	Pub. No.
Serial No.	 	C & E Ref.	 	Cadena Ref.	 	Status	 	Patent No.	 	 	Issue Date	 
	1	 	 POLYMERIC ACID CATALYSTS AND
 USES
THEREOF
  
 John M. Geremia

Brian M. Baynes
 Ashish Dhawan

 
 Corresponding to International Application PCT/US2012/026820

filed 2/27/2012
  

Priority information:
 61/447,311 filed 2/28/2011

61/522,351 filed 8/11/2011
	 	U.S.S.N.
 13/406,490Filed 2/27/2012
  
	 	51169-
 002003
	 	CAD-001 US3	 	Granted	 	 	9,079,171	 	 	 	7/14/2015	 
		 	U.S.S.N.
13/406,517 Filed
2/27/2012	 	51169-
 002004
	 	CAD-001 US4	 	Granted	 	 	8,466,242	 	 	 	6/18/2013	 
		 	U.S.S.N.
13/657,724 Filed
 10/22/2012 
	 	51169-
 002005
  
	 	CAD-001 US5 
	 	 Granted 
	 	   
	 8,476,388 
	   
	 	   
	 7/2/2013 
	   

		 	U.S.S.N.
13/865,048 Filed
4/17/2013	 	51169-
 002006
	 	CAD-001 US6	 	Granted	 	 	9,205,418	 	 	 	12/8/2015	 
		 	U.S.S.N.
 14/730,143*Filed 6/3/2015
  
	 	51169-
 002007
  
	 	CAD-001 US 
	 	 Pending 
	 				 			
		 	AR P20120100642
Filed 2/28/2012	 	51169-
 002AR3
	 	CAD-001 AR	 	Pending	 				 			
		 	AU 2012223494	 	51169-
 002AU3
	 	CAD-001 AU	 	Granted	 	 	2012223494	 	 	 	07/20/2017	 
		 	BR1120130220473	 	51169-
 002BR3
	 	CAD-001 BR	 	Pending	 				 			

  
 5 

															
	 	 	 Title/lnventors
	 	Pub. No.
Serial No.	 	C & E Ref.	 	Cadena Ref.	 	Status	 	Patent No.	 	Issue Date
		 		 	CA 2,864,086	 	51169-
 002CA3
	 	CAD-001 CA	 	Allowed	 		 	
		 		 	CL 2463-2013	 	51169-
 002CL3
	 	CAD-001 CL	 	Abandoned	 		 	
		 		 	CN 201280018901.2	 	51169-
 002CN3
	 	CAD-001 CN	 	Allowed	 		 	
		 		 	CO 13230542	 	51169-
 002C03
	 	CAD-001 CO	 	Granted	 	30876	 	08/15/2015
		 		 	EP 12709207.0	 	51169-
 002EP3
	 	CAD-001 EP1	 	Granted	 	2681547	 	04/04/2018
		 		 	EP 18163838.8	 	51169-
 002EP4
	 	CAD-001 EP2	 	Pending	 		 	
		 		 	ID W00201304395	 	51169-
 002ID3
	 	CAD-001 ID	 	Granted /
 Revival
 Pending
	 	465560	 	06/20/2017
		 		 	IN 7946/DELNP/2013	 	51169-
 002IN3
	 	CAD-001 IN	 	Pending	 		 	
		 		 	JM 18/1/5278	 	51169-
 002JM3
	 	CAD-001 JM	 	Pending	 		 	
		 		 	KR 10-2013-7018658	 	51169-
 002KR3
	 	CAD-001 KR	 	Abandoned	 		 	
		 		 	MX/a/2013/009920	 	51169-
 002MX3
	 	CAD-001 MX	 	Granted	 	344405
 (associate returned to
the patent office for
correction)
	 	TBD
		 		 	MX/a/2015/016430	 	51169-
 002MX4
	 	CAD-001 MX	 	Pending	 		 	
		 		 	MY PI 2013003157	 	51169-
 002MY3
	 	CAD-001 MY	 	Abandoned	 		 	
		 		 	NZ 616047	 	51169-
 002NZ3
	 	CAD-001 NZ	 	Granted	 	616047	 	3/30/2016
		 		 	PH 1-2013-501775	 	51169-
002PH3	 	CAD-001 PH	 	Pending	 		 	
		 		 	RU 2013143822	 	51169-
 002RU3
	 	CAD-001 RU	 	Abandoned	 		 	
		 		 	SG 201306465-4	 	51169-
 002SG3
	 	CAD-001 SG	 	Granted	 	192958	 	3/9/2016
		 		 	TH 1301004754	 	51169-
 002TH3
	 	CAD-001 TH	 	Pending	 		 	
		 		 	ZA 2013/06233	 	51169-
 002ZA3
	 	CAD-001 ZA	 	Accepted	 		 	
	2	 	 METHODS OF PRODUCING SUGARS FROM BIOMASS FEEDSTOCKS
  

Brian M. Baynes
 John M. Geremia

Joseph Andoh
 Ashish Dhawan

 
 Priority information:

61/693,210 filed 8/24/2012
  
	 	U.S.S.N. 13/831,495
Filed 3/14/2013	 	51169-
 003001
	 	CAD-006 US2	 	Granted	 	9,238,845	 	1/19/2016
	3	 	 POLYMERIC AND SOLID-SUPPORTED CATALYSTS, AND METHODS OF DIGESTING CELLULOSIC MATERIALS

USING SUCH CATALYSTS
  

John M. Geremia
 Brian M. Baynes

Jaouad Fichtali
 Joseph Andoh
	 	U.S.S.N.
 14/423,697*
 Filed
2/24/2015
	 	51169-
 004004
	 	CAD-004 US	 	Abandoned	 		 	
		 	CA 2,922,254	 	51169-
 004CA4
	 	CAD-004 CA	 	Pending /
 To beabandoned
  
	 		 	
		 	CN 201380055050.3	 	51169-
 004CN4
	 	CAD-004 CN	 	Granted	 	ZL201380055050.3	 	4/12/2017
		 	EP 13831228.5	 	51169-
 004EP4
	 	CAD-004 EP	 	Pending /
 To beabandoned
	 		 	

  
 6 

															
	 	 	 Title/Inventors
	 	Pub. No.
Serial No.	 	C & E Ref.	 	Cadena Ref.	 	Status	 	Patent No.	 	Issue Date
		 	 Corresponding to International
 Application No.
PCT/US2013/056389
 filed 8/23/2013
  

Priority Information:
 61/693,200 filed 8/24/2012

61/693,210 filed 8/24/2012
 61/693,213 filed 8/24/2012

 
	 	KR 10-2015-
7007481	 	51169-
 004KR4
	 	CAD-004 KR	 	Pending /
 To beabandoned
	 		 	
	4	 	 POLYMERIC AND SOLID-SUPPORTED

CATALYSTS, AND METHODS OF
 DIGESTING LIGNIN-CONTAINING

MATERIALS USING SUCH CATALYSTS
  

John M. Geremia
  

Corresponding to International
 Application No.
PCT/US2013/056462
 filed 8/23/2013
  

Priority Information:
 61/693,216 filed 8/24/2012
	 	U.S.S.N.
14/423,698*
Filed 2/24/2015	 	51169-
 005002
	 	CAD-008 US	 	Abandoned	 		 	
		 	EP 13830609.7	 	51169-
 005EP2
	 	CAD-008 EP	 	Abandoned	 		 	

  
 7 

															
	 	 	 Title/Inventors
	 	Pub. No.
Serial No.	 	C & E Ref.	 	Cadena Ref.	 	Status	 	Patent No.	 	Issue Date
	5	 	 POLYMERIC IONIC SALT CATALYSTS
 AND
METHODS OF PRODUCING
 THEREOF
  

Brian M. Baynes

John M. Geremia

Joseph Andoh
  

Corresponding to International

Application No. PCT/US2014/024177

filed 3/12/2014
  

Priority Information:

61/786,230 filed 3/14/2013
	 	U.S.S.N.
 14/776,490*Filed 9/14/2015
	 	51169-
 006002
	 	CAD-010 US	 	Abandoned	 		 	
		 	AU 2014240435	 	51169-
 006AU2
	 	CAD-010 AU	 	Abandoned	 		 	
		 	BR1120150233260	 	51169-
 006BR2
	 	CAD-010 BR	 	Abandoned	 		 	
		 	CA 2,903,232	 	51169-
 006CA2
	 	CAD-010 CA	 	Abandoned	 		 	
		 	CL 2812-2015	 	51169-
 006CL2
	 	CAD-010 CL	 	Abandoned	 		 	
		 	CN 2014800279677	 	51169-
 006CN2
	 	CAD-010 CN	 	Abandoned	 		 	
		 	EA 201591749	 	51169-
 006EA2
	 	CAD-010 EA	 	Abandoned	 		 	
		 	EP 14773809.0	 	51169-
 006EP2
	 	CAD-010 EP	 	Abandoned	 		 	
		 	IL 241011	 	51169-
 006IL2
	 	CAD-010 IL	 	Abandoned	 		 	
		 	IN
 9479/DELNP/2015
	 	51169-
 006IN2
	 	CAD-010 IN	 	Abandoned	 		 	
		 	JP 2016-501432	 	51169-
 006JP2
	 	CAD-010 JP	 	Abandoned	 		 	
		 	KR 10-2015-
7029201	 	51169-
 006KR2
	 	CAD-010 KR	 	Pending/
 To beabandoned
	 		 	
		 	MX/a/2015/012436	 	51169-
 006MX2
	 	CAD-010 MX	 	Pending/
 To beabandoned
	 		 	
		 	NZ 711537	 	51169-
 006NZ2
	 	CAD-010 NZ	 	Abandoned	 		 	
		 	SG 11201507229Q	 	51169-
 006SG2
	 	CAD-010 SG	 	Abandoned	 		 	
		 		 	ZA 2015/06716	 	51169-
 006ZA2
	 	CAD-010 ZA	 	Abandoned	 		 	
	6	 	 METHODS FOR PRODUCING

OLIGOSACCHARIDES
  

John M. Geremia
 Scott Han

Alicia Landry
 Kyle Sherry

Stephan Panos
  

Corresponding to international

Application No. PCT/US2015/039795

filed 7/9/2015
  

Priority Information:

62/022,579 filed 7/9/2014

62/108,035 filed 1/26/2015
	 	U.S.S.N.
 14/795,720*Filed 7/9/2015
	 	51169-
 007003
	 	CAD-012 US	 	Pending	 		 	
		 	2015287703	 	51169-
 007AU3
	 	CAD-012 AU	 	Pending	 		 	
		 	BR112017000345-7	 	51169-
 007BR3
	 	CAD-012 BR	 	Pending	 		 	
		 	CA 2,954,662	 	51169-
 007CA3
	 	CAD-012 CA	 	Pending	 		 	
		 	201580048065.6	 	51169-
 0O7CN3
	 	CAD-012 CN	 	Pending	 		 	
		 	15819734.3	 	51169-
 007EP3
	 	CAD-012 EP	 	Pending	 		 	
		 	17111776.8	 	51169-
 007HK3
	 	CAD-012 HK	 	Pending	 		 	
		 	POO 2017 00913	 	51169-
 007ID3
	 	CAD-012 ID	 	Pending	 		 	
		 	249982	 	51169-
007IL3	 	CAD-012 IL	 	Pending	 		 	
		 	201717004105	 	51169-
 007IN3
	 	CAD-012 IN	 	Pending	 		 	
		 	2017-522455	 	51169-
 007JP3
	 	CAD-012 JP	 	Pending	 		 	
		 	MX/a/2017/000319	 	51169-
007MX3	 	CAD-012 MX	 	Pending	 		 	
		 	PI 2017000019	 	51169-
 007MY3
	 	CAD-012 MY	 	Pending	 		 	

  
 8 

																					
	 	 	 Title/Inventors
	 	 Pub. No.

Serial No.
	 	C & E Ref.	 	Cadena Ref.	 	 	Status	 	Patent No.	 	 	Issue Date	 
	 7
	 	 OLIGOSACCHARIDE COMPOSITIONS FOR USE AS FOOD INGREDIENTS AND METHODS OF PRODUCING THEREOF

 
 John M. Geremia

Raffi Mardirosian
 Michael J. Gidding

 
 Corresponding to International

Application PCT/US2016/013265
 filed January 13, 2016

 
 Priority information: 62/108,036 filed 1/26/2015
	 	U.S.S.N. 15/546,438 Filed 7/26/2017	 	51169-
 008002
	 	 	CAD-013US	 	 	Pending	 	 	            	 	 	 	            	 
	 	AU 2016212025	 	51169-
 008AU2
	 	 	CAD-013AU	 	 	Pending	 				 			
	 	BR 1120170159465	 	51169-
 008BR2
	 	 	CAD-013BR	 	 	Pending	 				 			
	 	CA 2,975,091	 	51169-
 008CA2
	 	 	CAD-013CA	 	 	Pending	 				 			
	 	CN 201680016821.1	 	51169-
008CN2	 	 	CAD-013CN	 	 	Pending	 				 			
	 	EP 16743841.5	 	51169-
008EP2	 	 	CAD-013EP	 	 	Pending	 				 			
	 	Hong Kong	 	51169-
 008HK2
	 	 	CAD-013HK	 	 	To be filed	 				 			
	 	ID PID201705111	 	51169-
 008ID2
	 	 	CAD-013ID	 	 	Pending	 				 			
	 	IN 201717028052	 	51169-
 008IN2
	 	 	CAD-013IN	 	 	Pending	 				 			
	 	JP 2017-557270	 	51169-
 008JP2
	 	 	CAD-013JP	 	 	Pending	 				 			
	 		 	MX/a/2017/009722	 	51169-
 008MX2
	 	 	CAD-013MX	 	 	Pending	 				 			
	 		 	MY PI 2017001086	 	51169-
 008MY2
	 	 	CAD-013MY	 	 	Pending	 				 			
	 		 	PH 1-2017-501341	 	51169-
 008PH2
	 	 	CAD-013PH	 	 	Pending	 				 			
	 		 	RU 2017130166	 	51169-
 008RU2
	 	 	CAD-013RU	 	 	Pending	 				 			
	 		 	ZA 2017/05200	 	51169-
 008ZA2
	 	 	CAD-013ZA	 	 	Pending	 				 			
	 8
	 	 OLIGOSACCHARIDE COMPOSITIONS FOR USE IN NUTRITIONAL COMPOSITIONS, AND METHODS OF PRODUCING THEREOF

 
 John M. Geremia

 
 Corresponding to international

Application PCT/US2O16/013271
 Filed January 13, 2016

 
 Priority information:

62/108,038 filed 1/26/2015
	 	U.S.S.N 15/546,508 filed 07/26/2017	 	51169-
 010002
	 	 	CAD-015US	 	 	Pending	 				 			
	 	AU 2016212026	 	51169-
 010AU2
	 	 	CAD-015AU	 	 	Pending	 				 			
	 	CA 2,975,093	 	51169-
 010CA2
	 	 	CAD-015CA	 	 	Pending	 				 			
	 	CN 201680016981.6	 	51169-
 010CN2
	 	 	CAD-015CN	 	 	Pending	 				 			
	 	EP 16743842.3	 	51169-
 010EP2
	 	 	CAD-015EP	 	 	Pending	 				 			
	 	Hong Kong	 	51169-
 010HK2
	 	 	CAD-015HK	 	 	To be filed	 				 			
	 	JP 2017-557271	 	51169-
 010JP2
	 	 	CAD-015JP	 	 	Pending	 				 			
	 	MX/a/2017/009720	 	51169-
 010MX2
	 	 	CAD-015MX	 	 	Pending	 				 			
	 9
	 	 METHODS OF PRODUCING ANHYDROSUGAR ALCOHOLS
  

John M. Geremia:
  

Priority information:
 U.S.S.N. 62/108,460 filed
1/27/2015
	 	PCT/US2016/014109 Filed 1/20/2016	 	51169-
 012WO2
	 	 	CAD-017 WO	 	 	Expired	 				 			
	 10
	 	OLIGOSACCHARIDE COMPOSITIONS FOR USE AS ANIMAL FEED AND METHODS OF PRODUCING THEREOF	 	 U.S.S.N.
 14/995,129*

Filed 1/13/2016
	 	51169-
 017001
	 	 	CAD-014 US	 	 	Pending	 				 			
	 	BR 1120170159449	 	51169-
 017BR1
	 	 	CAD-014BR	 	 	Pending	 				 			

  
 9 

																			
	 	  	 Title/Inventors
	  	 Pub. No.

Serial No.
	 	C & E Ref.	 	Cadena Ref.	 	Status	 	Patent No.	 	 	Issue Date	 
		  	 John M. Geremia
 Raffi
Mardirosian
 Michael J. Gidding
 Anastasia V. Murphy

 
 Corresponding to

PCT/US2016/013280
 Filed 1/13/2016

 
 Priority Information:

62/108,037 filed 1/26/2015
 62/216,945 filed 9/10/2015

62/216,952 filed 9/10/2015
 62/255,341 filed 11/13/2015

62/255,343 filed 11/13/2015
	  	CA 2,975,095	 	51169-
 017CA1
	 	CAD-014CA	 	Pending	 				 			
	  	CN 201680016822.6	 	51169-
 017CN1
	 	CAD-014CN	 	Pending	 				 			
	  	EP 16743843.1	 	51169-
 017EP1
	 	CAD-014EP	 	Pending	 				 			
	  	Hong Kong	 	51169-
 Q17HK1
	 	CAD-014HK	 	To be filed	 				 			
	  	IN 201717026993	 	51169-
017IN1	 	CAD-014IN	 	Pending	 				 			
	  	IP 2017-557272	 	51169-
O17JP1	 	CAD-014JP	 	Pending	 				 			
	  	MX/a/2017/009730	 	51169-
 017MX1
	 	CAD-014MX	 	Pending	 				 			
	 11
	  	 ANIMAL THERAPEUTIC AND FEED COMPOSITIONS AND METHODS OF USE

 
 John M. Geremia

Anastasia V. Murphy
  

Priority information:
 62/255,348 filed 11/13/2015

62/255,352 filed 11/13/2015
	  	PCT/US2016/061337 Filed 11/10/2016	 	51169-
 020WO1
	 	CAD-020WO	 	National
Stage Filings	 				 			
	  	15/775,501	 	51169-
 020001
	 	CAD-020US	 	Pending	 				 			

  

	*	 US Utility application, not a national phase.  

Trademarks: 
 The following marks have been applied for
but not yet granted, unless otherwise noted. 
  

									
	 Application No.
	  	 Mark
	  	 Country
	  	 Filing Date
	  	 Status

	 A0066335
	  	CADENABIO	  	International Application (Madrid Protocol designating AU, CN, EM, IN, JP, MX)	  	13-Apr-2017	  	AU, CN, IN, JP, and MX will be passively abandoned
					
	 87/203,406
	  	CADENABIO	  	United States	  	14-Oct-2016	  	Pending
					
	 912585048
	  	CADENABIO	  	Brazil	  	13-Apr-2017	  	Abandoned
					
	 1,831,930
	  	CADENABIO	  	Canada	  	10-Apr-2017	  	Abandoned
					
	 87/203,415
	  	OPTlBIOME	  	United States	  	14-Oct-2016	  	Abandoned
					
	 87/244,879
	  	BIOMESENTIALS	  	United States	  	22-Nov-2016	  	Abandoned
					
	 A0067115
	  	BIOMESSENTIALS	  	International Application (Madrid Protocol designating AU*, CN, EM, IN#, JP, MX)	  	17-May-2017	  	Pending

  
 10 

									
					
	 87/318,742
	  	BIOMESSENTIALS	  	United States	  	31-Jan-20l7	  	Pending
					
	 912756225
	  	BIOMESSENTIALS	  	Brazil	  	22-May-2017	  	Pending
					
	 1,838,164
	  	BIOMESSENTIALS	  	Canada	  	17-May-2017	  	Pending

  

	*	 registered  

	# 	 abandoned 

  

	 	II)	 Kaleido IP Assets: 

Patents: 
 U.S. 9,492,473, Glycan Therapeutics and Related
Methods Thereof 
 U.S. 9,757,403, Glycan Therapeutics and Related Methods Thereof 

U.S. 9,901,595, Glycan Therapeutics and Related Methods Thereof 

EP 3071235 Glycan Therapeutic Compositions and Related Methods Thereof  

Patents and Applications: 
  

									
	 Application No.
	  	Country	  	 Status
	  	 Filing Date
	  	 Application Title

	2016212030	  	AU	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
	1120170156148	  	BR	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
	2973617	  	CA	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
	201701901	  	CL	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
	201680017749.4	  	CN	  	Published	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
	201791702	  	EA	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
	16704085.6	  	EP	  	Granted	  	13-Jan-2016	  	GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF
	17206409.9	  	EP	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF
	17102650.8	  	HK	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
	PID201704900	  	ID	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF
	253195	  	IL	  	Pending	  	13-Jan-2016	  	GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

  
 11 

									
	 Application No.
	  	Country	  	 Status
	  	 Filing Date
	  	 Application Title

	201717026559	  	IN	  	Published	  	13-Jan-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	2017-557273	  	JP	  	Published	  	13-Jan-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	10-2017-7023785	  	KR	  	Pending	  	13-Jan-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	MX/a/2017/009589	  	MX	  	Pending	  	13-Jan-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	PI2017001075	  	MY	  	Pending	  	13-Jan-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	733270	  	NZ	  	Pending	  	13-Jan-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	1-2017-501342	  	PH	  	Pending	  	13-Jan-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	11201706033X	  	SG	  	Pending	  	13-Jan-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	62/152005	  	US	  	Expired	  	23-Apr-2015	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR METABOLIC DISEASES

	62/216993	  	US	  	Expired	  	10-Sep-2015	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR METABOLIC DISEASES

	15/017396	  	US	  	Granted	  	05-Feb-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	15/286382	  	US	  	Granted	  	05-Oct-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	15/385331	  	US	  	Granted	  	20-Dec-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	15/374511	  	US	  	Abandoned	  	09-Dec-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	15/624372	  	US	  	Pending	  	15-Jun-2017	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	15/866152	  	US	  	Pending	  	09-Jan-2018	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	PCT/US2016/013305	  	WO	  	Inactive	  	13-Jan-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	2017/04735	  	ZA	  	Pending	  	13-Jan-2016	  	 GLYCAN THERAPEUTICS AND RELATED METHODS THEREOF

	2016253010	  	AU	  	Pending	  	23-Apr-2016	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF

	2983236	  	CA	  	Pending	  	23-Apr-2016	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF

  
 12 

									
	 Application No.
	  	Country	  	Status	  	 Filing Date
	  	 Application Title

	 201680035931.2
	  	CN	  	Published	  	23-Apr-2016	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF

	 16722465.8
	  	EP	  	Published	  	23-Apr-2016	  	 GLYCAN THERAPEUTICS AND METHODS OF TREATMENT

	 2017-555593
	  	JP	  	Pending	  	23-Apr-2016	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF

	 735895
	  	NZ	  	Pending	  	23-Apr-2016	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF

	 62/152007
	  	US	  	Expired	  	23-Apr-2015	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR INFLAMMATORY DISEASES

	 62/216995
	  	US	  	Expired	  	10-Sep-2015	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR INFLAMMATORY DISEASES

	 15/568243
	  	US	  	Pending	  	23-Apr-2016	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND RELATED METHODS THEREOF

	 PCT/US2016/029070
	  	WO	  	Abandoned	  	22-Apr-2016	  	 GLYCAN THERAPEUTICS AND METHODS OF TREATMENT

	 PCT/US2016/029082
	  	WO	  	Inactive	  	23-Apr-2016	  	 GLYCAN THERAPEUTICS AND METHODS OF TREATMENT

	 2016253011
	  	AU	  	Pending	  	23-Apr-2016	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 2983016
	  	CA	  	Pending	  	23-Apr-2016	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 201680036013.1
	  	CN	  	Published	  	23-Apr-2016	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 16724150.4
	  	EP	  	Pending	  	23-Apr-2016	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 201717036757
	  	IN	  	Published	  	23-Apr-2016	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 2017-555594
	  	JP	  	Pending	  	23-Apr-2016	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 MX/a/2017/013562
	  	MX	  	Pending	  	23-Apr-2016	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 735897
	  	NZ	  	Pending	  	23-Apr-2016	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 2017134547
	  	RU	  	Pending	  	23-Apr-2016	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 11201708635Q
	  	SG	  	Pending	  	23-Apr-2016	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 62/152011
	  	US	  	Expired	  	23-Apr-2015	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR INFECTIOUS DISEASES

  
 13 

									
	 Application No.
	  	Country	  	Status	  	 Filing Date
	  	 Application Title

	 62/216997
	  	US	  	Expired	  	 10-Sep-2015
	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR INFECTIOUS DISEASES

	 15/568251
	  	US	  	Pending	  	 23-Apr-2016
	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 PCT/US2016/029065
	  	WO	  	Abandoned	  	 22-Apr-2016
	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 PCT/US2016/029083
	  	WO	  	Inactive	  	 23-Apr-2016
	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 2017/06675
	  	ZA	  	Pending	  	 23-Apr-2016
	  	 MICROBIOME REGULATORS AND RELATED USES THEREOF

	 62/152016
	  	US	  	Expired	  	 23-Apr-2015
	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR MICROBIOME DISEASES

	 62/217002
	  	US	  	Expired	  	 10-Sep-2015
	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR MICROBIOME DISEASES

	 62/152017
	  	US	  	Expired	  	 23-Apr-2015
	  	 HYBRID GLYCAN STRUCTURES, THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR ALTERING THE
MICROBIOTA

	 62/209615
	  	US	  	Expired	  	25-Aug-2015	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF OF THE MODULATION OF SKIN
MICROBIOTA

	 2016311452
	  	AU	  	Pending	  	25-Aug-2016	  	 GLYCAN COMPOSITIONS AND USES THEREOF

	 2994430
	  	CA	  	Pending	  	25-Aug-2016	  	 GLYCAN COMPOSITIONS AND USES THEREOF

	 201680059550.8
	  	CN	  	Pending	  	25-Aug-2016	  	 GLYCAN COMPOSITIONS AND USES THEREOF

	 16778131.9
	  	EP	  	Pending	  	25-Aug-2016	  	 GLYCAN COMPOSITIONS AND USES THEREOF

	 2018-510084
	  	JP	  	Pending	  	25-Aug-2016	  	 GLYCAN COMPOSITIONS AND USES THEREOF

	 MX/a/2018/002301
	  	MX	  	Pending	  	25-Aug-2016	  	 GLYCAN COMPOSITIONS AND USES THEREOF

	 739502
	  	NZ	  	Pending	  	25-Aug-2016	  	 GLYCAN COMPOSITIONS AND USES THEREOF

  
 14 

									
	 Application No.
	  	Country	  	Status	  	Filing Date	  	 Application Title

	 62/209618
	  	US	  	Expired	  	25-Aug-2015	  	 GLYCAN THEREAPEUTIC COMPOSITIONS AND USES THEREOF FOR THE MODULATION OF VAGINAL
MICROBIOTA

	 15/754850
	  	US	  	Pending	  	25-Aug-2016	  	 GLYCAN COMPOSITIONS AND USES THEREOF

	 PCT/US2016/048794
	  	WO	  	Inactive	  	25-Aug-2016	  	 GLYCAN COMPOSITIONS AND USES THEREOF

	 62/209626
	  	US	  	Expired	  	25-Aug-2015	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR THE MODULATION OF ORAL
MICROBIOTA

	 62/209629
	  	US	  	Expired	  	25-Aug-2015	  	 GLYCAN THERAPEUTIC COMPOSITIONS AND USES THEREOF FOR THE MODULATION OF NASAL
MICROBIOTA

	 62/238110
	  	US	  	Expired	  	06-Oct-2015	  	 GLYCAN THERAPEUTICS COMPRISING POLYPHENOLS AND USES THEREOF IN INFECTIOUS AND INFLAMMATORY
DISEASES

	 62/238112
	  	US	  	Expired	  	06-Oct-2015	  	 GLYCAN THERAPEUTICS COMPRISING POLYPHENOLS AND USES THEREOF IN METABOLIC AND MICROBIOME-ASSOCIATED DISEASES

	 62/255365
	  	US	  	Expired	  	13-Nov-2015	  	 MICROBIOME REGULATORS AND USES THEREOF IN INFECTIOUS AND INFLAMMATORY DISEASES

	 62/255366
	  	US	  	Expired	  	13-Nov-2015	  	 MICROBIOME REGULATORS AND USES THEREOF IN MICROBIOME AND METABOLIC DISEASES

	 62/108039
	  	US	  	Expired	  	26-Jan-2015	  	 METHODS OF TREATING METABOLIC DISORDERS USING OLIGOSACCHARIDE COMPOSITIONS

	 62/278333
	  	US	  	Expired	  	13-Jan-2016	  	 METHODS OF TREATING CANCER

	 62/361998
	  	US	  	Expired	  	13-Jul-2016	  	 GLYCAN COMPOSITIONS AND METHODS OF USE

	 PCT/US2017/042022
	  	WO	  	Published	  	13-Jul-2017	  	 GLYCAN COMPOSITIONS AND METHODS OF USE

	 62/362025
	  	US	  	Expired	  	13-Jul-2016	  	 GLYCAN PREPARATIONS AND METHODS OF TREATMENT

	 62/367472
	  	US	  	Expired	  	27-Jul-2016	  	 GLYCAN PREPARATIONS AND METHODS OF TREATMENT

	 62/379677
	  	US	  	Abandoned	  	25-Aug-2016	  	 GLYCAN PREPARATIONS AND METHODS OF TREATMENT

  
 15 

									
	 Application No.
	  	Country	  	Status	  	 Filing Date
	  	 Application Title

	 62/435052
	  	US	  	Abandoned	  	15-Dec-2016	  	 GLYCAN PREPARATIONS AND METHODS OF TREATMENT

	 62/367616
	  	US	  	Inactive	  	27-Jul-2016	  	 GLYCAN THERAPEUTICS AND VARIATIONS THEREOF

	 62/379676
	  	US	  	Abandoned	  	25-Aug-2016	  	 GLYCAN THERAPEUTICS AND VARIATIONS THEREOF

	 62/430895
	  	US	  	Expired	  	06-Dec-2016	  	 GLYCAN POLYMERS AND RELATED METHODS THEREOF

	 62/446316
	  	US	  	Expired	  	13-Jan-2017	  	 GLYCAN POLYMERS AND RELATED METHODS THEREOF

	 PCT/US2017/064974
	  	WO	  	Pending	  	06-Dec-2017	  	 GLYCAN POLYMERS AND RELATED METHODS THEREOF

	 62/430849
	  	US	  	Expired	  	06-Dec-2016	  	 GLYCAN POLYMERS AND METHODS OF SYNTHESIS THEREOF

	 62/581517
	  	US	  	Pending	  	03-Nov-2017	  	 MANAGEMENT OF INFECTIONS

	 62/581577
	  	US	  	Pending	  	03-Nov-2017	  	 GLYCAN PREPARATIONS AND METHODS OF USE IN ACIDEMIAS

	 62/581592
	  	US	  	Pending	  	03-Nov-2017	  	 GLYCAN PREPARATIONS AND METHODS OF USE IN HYPEROXALURIA

	 62/581601
	  	US	  	Pending	  	03-Nov-2017	  	 GLYCAN PREPARATIONS AND METHODS OF USE IN TRIMETHYLAMINURIA

	 62/581583
	  	US	  	Pending	  	03-Nov-2017	  	 GLYCAN PREPARATIONS AND METHODS OF USE IN UREA CYCLE DISORDERS

	 62/581571
	  	US	  	Pending	  	03-Nov-2017	  	 METHODS OF PRODUCING GLYCAN POLYMERS

	 62/581613
	  	US	  	Pending	  	03-Nov-2017	  	 METHODS AND COMPOSITIONS COMPRISING GLYCAN POLYMER PREPARATIONS

	 62/581589
	  	US	  	Pending	  	03-Nov-2017	  	 GLYCAN PREPARATIONS AND METHODS OF USE IN HYPERURICEMIA

  
 16 

									
	 Application No.
	  	Country	  	Status	  	 Filing Date
	  	 Application Title

	 62/581612
	  	US	  	Pending	  	03-Nov-2017	  	 GLYCAN PREPARATIONS AND MICROBES

	 62/581607
	  	US	  	Pending	  	03-Nov-2017	  	 GLYCAN PREPARATIONS AND METHODS OF MAKING SAME

	 62/614966
	  	US	  	Pending	  	08-Jan-2018	  	 GLYCAN PREPARATIONS AND METHODS OF USE FOR TREATING
NON-ALCOHOLIC FATTY LIVER DISEASE

	 62/614970
	  	US	  	Pending	  	08-Jan-2018	  	 GLYCAN PREPARATIONS AND METHODS OF USE IN RENAL DISEASES

	 62/619084
	  	US	  	Pending	  	18-Jan-2018	  	 GLYCAN COMPOSITIONS AND METHODS OF USE

 Trademarks: 
 The
following marks have been applied for but not yet granted, unless otherwise noted. 
  

											
	 App No.
	  	 Mark
	  	 Country
	  	Filing Date	  	Status	  	 Oppositions

	 1776706
	  	KALEIDO	  	Canada	  	11-Apr-2016	  	Pending	  	
	 1314387
	  	KALEIDO	  	 Int’I Registration-Madrid Protocol*

designating: Japan*, China, Europe, Mexico*
	  	08-Apr-2016	  	*Registered	  	OPPOSITION NO. B 002849142: MENARINI INTERNATIONAL OPERATIONS LUXEMBOURG S.A. of the KALEIDO mark based on Menarini’s prior rights in KALEIDON (EUTM No. 004712998) for “pharmaceutical and veterinary preparations;
sanitary preparations for medical purposes; dietetic substances adapted for medical use, food for babies” in Class 5
	 017224072
	  	KALEIDO	  	Europe	  	20-Sep-2017	  	Registered,
class 1	  	
	 86/783357
	  	KALEIDO	  	United States of America	  	09-Oct-2015	  	Pending,
class 5	  	
	 87/195340
	  	 MICROBIOME
 ENHANCER
	  	United States of America	  	06-Oct-2016	  	Pending,
class 5	  	

  
 17 

 SIXTH AMENDMENT 

TO 
 LOAN AND SECURITY
AGREEMENT 
 This Sixth Amendment to Loan and Security Agreement (this “Amendment”) is made and entered into as of
November 8, 2018, by and among PACIFIC WESTERN BANK, a California state chartered bank (“Bank”), and KALEIDO BIOSCIENCES, INC. and CADENA BIO, INC. (individually and collectively referred to as
“Borrower”). 
 RECITALS 

Borrower and Bank are parties to that certain Loan and Security Agreement dated as of December 21, 2015 (as amended from time to time, the
“Agreement”). The parties desire to amend the Agreement in accordance with the terms of this Amendment. 
 NOW, THEREFORE, the
parties agree as follows: 
  

	1)	 A new subsection (1) is hereby added to the defined term “Permitted Indebtedness” in Exhibit A
to the Agreement, as follows: 

 (1) Indebtedness not to exceed $1,000,000 in the aggregate outstanding at
any time arising under an unsecured credit card issued by American Express. 
  

	2)	 Unless otherwise defined herein, all initially capitalized terms in this Amendment shall be as defined in the
Agreement. The Agreement, as amended hereby, shall be and remain in full force and effect in accordance with its respective terms and hereby is ratified and confirmed in all respects. Except as expressly set forth herein, the execution, delivery,
and performance of this Amendment shall not operate as a waiver of, or as an amendment of, any right, power, or remedy of Bank under the Agreement, as in effect prior to the date hereof. Each Borrower ratifies and reaffirms the continuing
effectiveness of all agreements entered into in connection with the Agreement. 

  

	3)	 Each Borrower represents and warrants that the representations and warranties contained in the Agreement are
true and correct in all material respects as of the date of this Amendment. 

  

	4)	 This Amendment may be executed in two or more counterparts, each of which shall be deemed an original, but all
of which together shall constitute one instrument. 

  

	5)	 As a condition to the effectiveness of this Amendment, Bank shall have received, in form and substance
satisfactory to Bank, the following: 

 a) this Amendment, duly executed by each Borrower; 

b) payment of all Bank Expenses incurred through the date of this Amendment, including Bank’s expenses for the
documentation of this Amendment and any UCC, good standing or intellectual property search or filing fees, which may be debited from any Borrower’s accounts; and 

 c) such other documents and completion of such other matters, as Bank may
have reasonably requested. 
 [Signature Page Follows] 

 IN WITNESS WHEREOF, the undersigned have executed this Amendment as of the first date above written. 

 

									
	KALEIDO BIOSCIENCES, INC.	 		 	CADENA BIO, INC.
					
	By:	 	 Jeffrey Moore
	 		 	By:	 	 Jeffrey Moore

	Name:	 	 Jeffrey Moore
	 		 	Name:	 	 Jeffrey Moore

	Title:	 	 SVP, Finance & Administration
	 		 	Title:	 	 Secretary

  

			
	PACIFIC WESTERN BANK
		
	By:	 	 
	Name:	 	 
	Title:	 	 

 [Signature Page to Sixth Amendment to Loan and Security Agreement] 

 IN WITNESS WHEREOF, the undersigned have executed this Amendment as of the first date above written. 

 

									
	KALEIDO BIOSCIENCES, INC.	 		 	CADENA BIO, INC.
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	  
	 		 	Name:	 	  

	Title:	 	  
	 		 	Title:	 	  

  

			
	PACIFIC WESTERN BANK
		
	By:	 	Scott Hansen
	Name:	 	Scott Hansen
	Title:	 	SVP

 [Signature Page to Sixth Amendment to Loan and Security Agreement]EX-10.13

 Exhibit 10.13 

65 HAYDEN AVENUE 
 LEXINGTON,
MASSACHUSETTS 02421 
 LEASE SUMMARY SHEET 
  

			
	Execution Date:	  	March 19, 2018
		
	Tenant:	  	 KALEIDO BIOSCIENCES, INC.,
 a Delaware
corporation

		
	Tenant’s Mailing Address Prior to Occupancy:	  	Kaleido Biosciences, Inc.
18 Crosby Drive
Bedford, MA 01730
Attention: Chief Financial Officer
		
	Landlord:	  	 HCP/KING HAYDEN CAMPUS LLC,
 a Delaware
limited liability company

		
	Building:	  	65 Hayden Avenue, Lexington, Massachusetts 02421. The Building consists of approximately 213,005 rentable square feet, including a four-story garage with 298 spaces (the “Garage”). The Building consists of two wings-the North Building and the South Building. The land (the “Land”) on which the Building and the Garage are located is described as “Parcel Three” and “Parcel
Four” on Exhibit 2 attached hereto and made a part hereof.
		
	Campus:	  	All of the land described on Exhibit 2 (including the Land described above) together with the Building described above, the buildings now known as and numbered 45 Hayden Avenue and 55 Hayden Avenue, and any other building
and/or improvements constructed on the Land.
		
	Premises:	  	 Prime Premises, which are areas on (i) the first (1st) floor of the north
portion of the Building (the “North Premises”), and (ii) the first (1st) floor of the south portion of the Building (the “South Premises”) containing
approximately 52,815 rentable square feet in the aggregate. The North Premises consist of 39,430 rentable square feet, and the South Premises consist of 13,385 rentable square feet.

 
 PH System Premises, which are located on the first (1st) floor. The PH System Premises are located in a room ( the “PH System Room”) that contains the PH systems of other tenants.

 
 The term “Premises” shall mean the Prime Premises and the PH System
Premises. The Premises are shown on the Lease Plans attached hereto as Exhibit 1A, and Exhibit 1B and made a part hereof (the “Lease Plans”).
  

Landlord and Tenant stipulate and agree that the Rentable Square Footage of the Building and the Rentable Square Footage of the Premises are correct and shall
not be remeasured.

  
 PAGE 1 

			
	Property:	  	The Building, the Garage, the Land, and other improvements located on, and to be constructed on, the Land.
		
	Parking Areas:	  	The parking structures (surface lots and parking decks, including the Garage adjacent to the Building) located on the Campus that Landlord provides for parking by all tenants of space on the Property, as the same may change from
time to time as contemplated pursuant to Section 2.2 of this Lease.
		
	 Term
 Commencement

Dates:
	  	 North Premises: The date (the “North Premises Term Commencement Date”) that is the earlier to occur of:

 
 (i) the date that Tenant first commences to
use the North Premises, or any portion thereof, for any Permitted Use, or
  

(ii)  the later of: (x) the date on which the Landlord’s North Premises Work has been
Substantially Completed (as hereinafter defined) or (y) September 1, 2018.
  

The parties estimate that the North Premises Term Commencement Date will occur on or about September 1, 2018 (“Estimated North Premises
Term Commencement Date”).
  
 South Premises: The date (the
“South Premises Term Commencement Date”) that is the earlier to occur of:
  

(i) the date that Tenant first commences to use the South Premises, or any portion thereof, for any Permitted
Use, or
  
 (ii)  the later of:
(x) the date on which the Landlord’s North Premises Work has been Substantially Completed (as hereinafter defined) or (y) October 1, 2018.
  

The parties estimate that the South Premises Term Commencement Date will occur on or about October 1, 2018 (“Estimated South Premises Term
Commencement Date”).

		
	 Base Rent Commencement

Dates:
	  	 North Premises: The North Premises Term Commencement Date.
  

South Premises: The later of: (i) the South Premises Term
Commencement Date, or (ii) October 1, 2018.

 

  
 PAGE 2 

			
	 Additional Rent Commencement

Dates:
	  	 North Premises: The North Premises Base Rent Commencement Date.

 
 South Premises: The earlier of: (i) the North Premises Base Rent
Commencement Date, or (ii) the South Premises Base Rent Commencement Date.

		
	Expiration Date:	  	The date that is ten (10) years from the date (“Date Determining Expiration Date”) which is the later of: (i) the North Premises Base Rent Commencement Date, and (ii) the South Premises Base
Rent Commencement Date for the South Premises, except that if the Date Determining the Expiration Date does not occur on the first day of a calendar month, then Expiration Date shall be the last day of the calendar month in which the tenth (10th) anniversary of the Date Determining the Expiration Date occurs.
		
	Extension Term(s):	  	Subject to Section 1.2 below, one (1) extension term of ten (10) years.
		
	Landlord’s Contributions:	  	 North Premises: Up to $3,548,700.00 (i.e., $ 90.00 per rentable square foot of the North Premises).

 
 South Premises: Up to $2,007,750.00 (i.e., $ 150.00 per rentable square foot of
the South Premises).
  
 Expansion Premises: Up to $ 70.00 per rentable square
foot of the Expansion Premises if Tenant elects to lease Expansion Premises.

		
	Permitted Uses:	  	 Subject to Legal Requirements, general office, research, development and laboratory use, including pilot production needs for food GMP Human
nutrition studies and GMP Human therapeutic clinical studies, and other ancillary uses related to the foregoing. Landlord makes no express warranty or representation, and disclaims any implied warranty or representation, that the Permitted Uses are
consistent or in compliance with any zoning or other land use ordinance, code or regulation, or any matters of public record.
  

Tenant acknowledges that it has performed such investigation as it deems appropriate to satisfy itself that the Premises are suitable for its purposes; and no
limitation on the uses permitted by law or any matters of public record shall entitle Tenant to an abatement of Rent, nor release Tenant from the prompt compliance with any of its obligations under this Lease

		
	Base Rent—North Premises-39,430 RSF:	  	 Notwithstanding anything to the contrary herein contained, Tenant’s obligation to pay Base Rent with respect to the North Premises shall
not commence until the North Premises Base Rent Commencement Date.
  

  
 PAGE 3 

							
	 	  	RENT YEAR	  	ANNUAL BASE
RENT**	  	MONTHLY
PAYMENT
	  	1	  	      $2,150,577.87***	  	      $172,506.25***
	  	2	  	$2,132,177.25	  	$177,681.44
	  	3	  	$2,196,142.57	  	$183,011.88
	  	4	  	$2,262,026.84	  	$188,502.24
	  	5	  	$2,329,887.65	  	$194,157.30
	  	6	  	$2,399,784.28	  	$199,982.02
	  	7	  	$2,471,777.81	  	$205,981.48
	  	8	  	$2,545,931.14	  	$212,160.93
	  	9	  	$2,622,309.08	  	$218,525.76
	  	10	  	$2,700,978.35	  	$225,081.53
	  	11	  	        $2,782,007.70****	  	$231,833.97

  

							
	 Base Rent—South

Premises—13,385
 RSF:
	  	 Notwithstanding anything to the contrary herein contained, Tenant’s obligation to pay Base Rent with respect to the South
Premises shall not commence until the South Premises Base Rent Commencement Date.
  

							
	 	  	RENT YEAR	  	ANNUAL BASE
RENT**	  	MONTHLY
PAYMENT
	  	1	  	  $702,712.50*	  	  $58,559.38*
	  	2	  	$723,793.88	  	$60,316.16
	  	3	  	$745,507.69	  	$62,125.64
	  	4	  	$767,872.92	  	$63,989.41
	  	5	  	$790,909.11	  	$65,909.09
	  	6	  	$814,636.38	  	$67,886.37
	  	7	  	$839,075.47	  	$69,922.96
	  	8	  	$864,247.74	  	$72,020.64
	  	9	  	$890,175.17	  	$74,181.26
	  	10	  	$916,880.43	  	$76,406.70
	  	11	  	        $944,386.84****	  	$78,698.90

  

							
		  	 *  Notwithstanding anything in this Section of the Lease to the
contrary, so long as there is no Event of Default (as defined in Section 20) by Tenant under this Lease, Tenant shall be entitled to an abatement of Base Rent for

  
 PAGE 4 

			
		  	 the South Premises for the second three-(3)-month period after the South Premises Base Rent Commencement Date (the
“South Premises Base Rent Abatement Period”) (i.e., if the South Premises Base Rent Commencement Date is October 1, 2018, then the South Premises Base Rent Abatement Period will be January 1, 2019 through
March 31, 2019). Notwithstanding the foregoing, in no event shall the South Premises Base Rent Abatement Period occur earlier than the period commencing January 1, 2019 and expiring March 31, 2019. During the South Premises Base Rent
Abatement Period, only Base Rent payable with respect to the South Premises shall be abated, and all Base Rent, Additional Rent and other costs and charges specified in this Lease shall remain as due and payable pursuant to the provisions of this
Lease.
 **   The Annual Base Rent per rentable square foot for each portion of the Premises, from
time to time, is set forth on Exhibit 12.
 ***   Notwithstanding the foregoing,
Tenant’s obligation to pay Monthly Rent payable by Tenant with respect to the North Premises during the Premium Rent Period, as hereinafter defined, shall be $161,005.84 (i.e., 200% of the amount of Base Rent which would be otherwise payable by
Tenant with respect to the North Premises during the Premium Rent Period, as determined by the schedule for Base Rent for the North Premises set forth above). The “Premium Rent Period” shall be defined as the first fourteen
(14) days of the Term of the Lease with respect to the North Premises, except that if the North Premises Base Rent Commencement Date occurs prior to September 1, 2018, then the Premium Rent Period shall be defined as September 1, 2018
through September 14, 2018, inclusive. For example, if the North Premises Base Rent Commencement Date occurs on September 1, 2018, then the monthly installment of Base Rent payable by Tenant with respect to the North Premises for the month
of September, 2018 shall be $253,009.17.
 ****  Annualized

 

	Rent Year:	  	 “Rent Year 1” with respect to the North Premises shall be the twelve (12) month period commencing as of the North
Premises Base Rent Commencement Date and ending as of the day (“Rent Year 1 End Date”) immediately preceding the first anniversary of the North Premises Base Rent Commencement Date, except that if the North Premises Base Rent
Commencement Date occurs on other than the first day of a calendar month, then the Rent Year 1 End Date shall be the last day of the calendar month in which the first anniversary of the North Premises Base Rent Commencement Date occurs.

 
 “Rent Year 1” with respect to the South Premises shall be the period
commencing as of the South Premises Base Rent Commencement Date and shall end as of the Rent Year 1 End Date.
  

  
 PAGE 5 

			
	 	  	Each Rent Year after Rent Year 1 for both the North Premises and South Premises shall be the twelve-
(12)-month period immediately following the preceding Rent Year (i.e., the annual increases in the Base
Rent for the South
Premises shall occur on at the same time as the annual increases in the Base Rent for
the North Premises).
		
	Operating Costs and Taxes:	  	See Sections 5.2 and 5.3.
		
	Tenant’s Share:	  	 A fraction, the numerator of which is the number of rentable square feet in the applicable portion of the Premises and the denominator of
which is the number of rentable square feet in the Building.
  
 As of the Execution
Date, Tenant’s Shares with respect to each portion of the Premises is

  

					
	 North Premises:
	  	 	18.51	% 
	 South Premises:
	  	 	6.28	% 
		  	  
	  
	 
	 Total:
	  	 	24.79	% 

  

			
	Security Deposit/ Letter of Credit:	  	$2,057,658.75, subject to reduction pursuant to Section 7 hereof.
		
	Guarantor:	  	None.

  

			
	EXHIBIT 1A	  	LEASE PLAN—PRIME PREMISES
	EXHIBIT 1B	  	LEASE PLAN—PH SYSTEM PREMISES
	EXHIBIT 1C	  	LEASE PLAN—EXPANSION PREMISES
	EXHIBIT 1C-A	  	LEASE PLAN—EXPANSION PREMISES A
	EXHIBIT 1C-B	  	LEASE PLAN—EXPANSION PREMISES B
	EXHIBIT 2	  	LEGAL DESCRIPTION—LAND
	EXHIBIT 3	  	PLAN – CURRENT PARKING AREAS
	EXHIBIT 3, SHEET 1	  	PLAN – CURRENT PARKING AREAS
	EXHIBIT 3, SHEET 2	  	PLAN – CURRENT PARKING AREAS
	EXHIBIT 4	  	WORK LETTER
	EXHIBIT 4-1	  	INITIAL PLAN FOR NORTH PREMISES
	EXHIBIT 4-2	  	EQUIPMENT UTILITY MATRIX FOR NORTH PREMISES
	EXHIBIT 4-3	  	ARCHITECTURAL BASIS OF DESIGN
	EXHIBIT 4-4	  	INITIAL PLAN FOR SOUTH PREMISES
	EXHIBIT 5-1	  	AREAS AVAILABLE TO TENANT IN SOUTH PENTHOUSE
	EXHIBIT 5-2	  	 AREAS AVAILABLE TO TENANT IN SOUTH
 MECHANICAL
ROOM

	EXHIBIT 5-3	  	 TENANT-SUPPLIED MECHANICAL EQUIPMENT

LOCATION

	EXHIBIT 6	  	FORM OF LETTER OF CREDIT
	EXHIBIT 7	  	LANDLORD’S SERVICES

  
 PAGE 6 

			
	EXHIBIT 8	  	TENANT’S HAZARDOUS MATERIALS
	EXHIBIT 9	  	RULES AND REGULATIONS
	EXHIBIT 9-1	  	BUILDING RULES AND REGULATIONS
	EXHIBIT 9-2	  	CONSTRUCTION RULES AND REGULATIONS
	EXHIBIT 10	  	TENANT WORK INSURANCE SCHEDULE
	EXHIBIT 11	  	ADDITIONAL PROVISIONS
	EXHIBIT 12	  	BASE RENT—PER-RENTABLE-SQUARE-FOOT AMOUNTS
	EXHIBIT 13	  	TENANT’S MONUMENT SIGNAGE

  
 PAGE 7 

 TABLE OF CONTENTS 
  

									
	1.        	  	LEASE GRANT; TERM; APPURTENANT RIGHTS; EXCLUSIONS	  	 	1	 
				
		  	1.1	  	Lease Grant	  	 	1	 
		  	1.2	  	Extension Term	  	 	1	 
		  	1.3	  	Appurtenant Rights	  	 	2	 
		  	1.4	  	Tenant’s Access	  	 	4	 
		  	1.5	  	No recording // Notice of Lease	  	 	5	 
		  	1.6	  	Exclusions	  	 	5	 
		  	1.7	  	Acid Neutralization Tank	  	 	5	 
		  	1.8	  	Standby Power	  	 	6	 
			
	2.	  	RIGHTS RESERVED TO LANDLORD	  	 	7	 
				
		  	2.1	  	Additions and Alterations	  	 	7	 
		  	2.2	  	Additions to the Property	  	 	7	 
		  	2.3	  	Name and Address of Building	  	 	8	 
		  	2.4	  	Landlord’s Access	  	 	8	 
		  	2.5	  	Pipes, Ducts and Conduits	  	 	10	 
		  	2.6	  	Minimize Interference	  	 	10	 
			
	3.	  	CONDITION OF PREMISES; CONSTRUCTION	  	 	10	 
				
		  	3.1	  	Condition of Premises	  	 	10	 
		  	3.2	  	Landlord’s Work	  	 	10	 
		  	3.3	  	Tenant’s Remedies in the Event of Delays in North Premises Term Commencement Date	  	 	12	 
			
	4.	  	USE OF PREMISES	  	 	13	 
				
		  	4.1	  	Permitted Uses	  	 	13	 
		  	4.2	  	Prohibited Uses	  	 	13	 
		  	4.3	  	MWRA Permit	  	 	14	 
		  	4.4	  	Parking and Traffic Demand Management Plan	  	 	14	 
			
	5.	  	RENT; ADDITIONAL RENT	  	 	15	 
				
		  	5.1	  	Base Rent	  	 	15	 
		  	5.2	  	Operating Costs	  	 	15	 
		  	5.3	  	Taxes	  	 	19	 
		  	5.4	  	Late Payments	  	 	20	 
		  	5.5	  	No Offset; Independent Covenants; Waiver	  	 	21	 
		  	5.6	  	Survival	  	 	22	 
			
	6.	  	INTENTIONALLY OMITTED	  	 	22	 
			
	7.	  	CASH SECURITY DEPOSIT/LETTER OF CREDIT	  	 	22	 
				
		  	7.1	  	Amount	  	 	22	 
		  	7.2	  	Application of Proceeds of Letter of Credit	  	 	23	 
		  	7.3	  	Transfer of Letter of Credit	  	 	23	 
		  	7.4	  	Cash Proceeds of Letter of Credit	  	 	23	 
		  	7.5	  	Return of Security Deposit or Letter of Credit	  	 	24	 
		  	7.6	  	Reduction of the Cash Security Deposit and/or Letter of Credit	  	 	24	 

  
 PAGE 1 

									
			
	8.        	  	INTENTIONALLY OMITTED	  	 	25	 
			
	9.	  	UTILITIES, LANDLORD’S SERVICES	  	 	25	 
				
		  	9.1	  	Electricity	  	 	25	 
		  	9.2	  	Water	  	 	26	 
		  	9.3	  	Gas	  	 	26	 
		  	9.4	  	Other Utilities	  	 	26	 
		  	9.5	  	Interruption or Curtailment of Utilities	  	 	26	 
		  	9.6	  	Landlord’s Services	  	 	27	 
			
	10.	  	MAINTENANCE AND REPAIRS	  	 	27	 
				
		  	10.1	  	Maintenance and Repairs by Tenant	  	 	27	 
		  	10.2	  	Maintenance and Repairs by Landlord	  	 	28	 
		  	10.3	  	Accidents to Sanitary and Other Systems	  	 	28	 
		  	10.4	  	Floor Load—Heavy Equipment	  	 	28	 
		  	10.5	  	Premises Cleaning	  	 	28	 
		  	10.6	  	Pest Control	  	 	29	 
		  	10.7	  	Service Interruptions	  	 	29	 
			
	11.	  	ALTERATIONS AND IMPROVEMENTS BY TENANT	  	 	30	 
				
		  	11.1	  	Procedures for Performing Alterations	  	 	30	 
		  	11.2	  	Harmonious Relations	  	 	32	 
		  	11.3	  	Liens	  	 	32	 
		  	11.4	  	General Requirements	  	 	32	 
			
	12.	  	SIGNAGE	  	 	32	 
				
		  	12.1	  	Restrictions	  	 	32	 
		  	12.2	  	Monument Signage	  	 	33	 
		  	12.3	  	Building Directory/Premises Entrance Signage	  	 	33	 
			
	13.	  	ASSIGNMENT, MORTGAGING AND SUBLETTING	  	 	33	 
				
		  	13.1	  	Landlord’s Consent Required	  	 	33	 
		  	13.2	  	Landlord’s Recapture Right	  	 	33	 
		  	13.3	  	Standard of Consent to Transfer	  	 	34	 
		  	13.4	  	Listing Confers no Rights	  	 	34	 
		  	13.5	  	Profits In Connection with Transfers	  	 	34	 
		  	13.6	  	Prohibited Transfers	  	 	34	 
		  	13.7	  	Exceptions to Requirement for Consent	  	 	35	 
		  	13.8	  	Flagship Subleases	  	 	35	 
			
	14.	  	INSURANCE; INDEMNIFICATION; EXCULPATION	  	 	36	 
				
		  	14.1	  	Tenant’s Insurance	  	 	36	 
		  	14.2	  	Indemnification	  	 	37	 
		  	14.3	  	Property of Tenant	  	 	37	 
		  	14.4	  	Limitation of Landlord’s Liability for Damage or Injury	  	 	38	 

  
 PAGE 2 

									
		  	14.5	  	Waiver of Subrogation; Mutual Release	  	 	38	 
		  	14.6	  	Tenant’s Acts—Effect on Insurance	  	 	38	 
		  	14.7	  	Landlord’s Insurance	  	 	39	 
			
	15.	  	CASUALTY; TAKING	  	 	39	 
				
		  	15.1	  	Damage	  	 	39	 
		  	15.2	  	Termination Rights	  	 	40	 
		  	15.3	  	Rent Abatement	  	 	41	 
		  	15.4	  	Taking for Temporary Use	  	 	41	 
		  	15.5	  	Disposition of Awards	  	 	42	 
			
	16.	  	ESTOPPEL CERTIFICATE	  	 	42	 
			
	17.        	  	HAZARDOUS MATERIALS	  	 	42	 
				
		  	17.1	  	Prohibition	  	 	42	 
		  	17.2	  	Environmental Laws	  	 	43	 
		  	17.3	  	Hazardous Material Defined	  	 	43	 
		  	17.4	  	Chemical Safety Program	  	 	43	 
		  	17.5	  	Testing	  	 	44	 
		  	17.6	  	Indemnity; Remediation	  	 	44	 
		  	17.7	  	Disclosures	  	 	46	 
		  	17.8	  	Removal	  	 	46	 
		  	17.9	  	Landlord Obligations with respect to Hazardous Materials	  	 	46	 
			
	18.	  	RULES AND REGULATIONS	  	 	47	 
				
		  	18.1	  	Rules and Regulations	  	 	47	 
		  	18.2	  	Energy Conservation	  	 	48	 
		  	18.3	  	Recycling	  	 	48	 
			
	19.	  	LAWS AND PERMITS	  	 	48	 
				
		  	19.1	  	Legal Requirements	  	 	48	 
			
	20.	  	DEFAULT	  	 	49	 
				
		  	20.1	  	Events of Default	  	 	49	 
		  	20.2	  	Remedies	  	 	51	 
		  	20.3	  	Damages—Termination	  	 	51	 
		  	20.4	  	Landlord’s Self-Help; Fees and Expenses	  	 	52	 
		  	20.5	  	Waiver of Redemption, Statutory Notice and Grace Periods	  	 	52	 
		  	20.6	  	Landlord’s Remedies Not Exclusive	  	 	53	 
		  	20.7	  	No Waiver	  	 	53	 
		  	20.8	  	Restrictions on Tenant’s Rights	  	 	53	 
		  	20.9	  	Landlord Default	  	 	53	 
			
	21.	  	SURRENDER; ABANDONED PROPERTY; HOLD-OVER	  	 	54	 
				
		  	21.1	  	Surrender	  	 	54	 
		  	21.2	  	Abandoned Property	  	 	55	 
		  	21.3	  	Holdover	  	 	56	 
		  	21.4	  	Warranties	  	 	56	 

  
 PAGE 3 

									
			
	22.        	  	MORTGAGEE RIGHTS	  	 	56	 
				
		  	22.1	  	Subordination	  	 	56	 
		  	22.2	  	Notices	  	 	57	 
		  	22.3	  	Mortgagee Consent	  	 	57	 
		  	22.4	  	Mortgagee Liability	  	 	57	 
			
	23.	  	QUIET ENJOYMENT	  	 	57	 
			
	24.	  	NOTICES	  	 	58	 
			
	25.	  	MISCELLANEOUS	  	 	58	 
				
		  	25.1	  	Separability	  	 	58	 
		  	25.2	  	Captions	  	 	58	 
		  	25.3	  	Broker	  	 	59	 
		  	25.4	  	Entire Agreement	  	 	59	 
		  	25.5	  	Governing Law	  	 	59	 
		  	25.6	  	Representation of Authority	  	 	59	 
		  	25.7	  	Expenses Incurred by Landlord	  	 	59	 
		  	25.8	  	Survival	  	 	60	 
		  	25.9	  	Limitation of Liability	  	 	60	 
		  	25.10	  	Binding Effect	  	 	60	 
		  	25.11	  	Landlord Obligations upon Transfer	  	 	61	 
		  	25.12	  	No Grant of Interest	  	 	61	 
		  	25.13	  	Financial Information	  	 	61	 
		  	25.14	  	OFAC Certificate and Indemnity	  	 	61	 
		  	25.15	  	Confidentiality	  	 	62	 
		  	25.16	  	Force Majeure	  	 	62	 

  
 PAGE 4 

 THIS INDENTURE OF LEASE (this “Lease”) is hereby made and entered into on
the Execution Date by and between Landlord and Tenant. 
 Each reference in this Lease to any of the terms and titles contained in any
Exhibit attached to this Lease shall be deemed and construed to incorporate the data stated under that term or title in such Exhibit. All capitalized terms not otherwise defined herein shall have the meanings ascribed to them as set forth in the
Lease Summary Sheet which is attached hereto and incorporated herein by reference. 
  

	1.	 LEASE GRANT; TERM; APPURTENANT RIGHTS; EXCLUSIONS 

1.1 Lease Grant. Landlord hereby leases to Tenant, and Tenant hereby leases from Landlord, the Premises upon and subject to terms and
conditions of this Lease, for a term of years commencing on the Term Commencement Date and, unless earlier terminated or extended pursuant to the terms hereof, ending on the Expiration Date (the “Initial Term”; the Initial Term and
any duly exercised Extension Terms are hereinafter collectively referred to as the “Term”). 
 1.2 Extension
Term.
 (a) Provided that the following conditions, which may be waived by Landlord in its sole discretion, are satisfied
(i) Kaleido Biosciences, Inc. itself, and/or any Permitted Transferee(s) (as defined in Section 13.7) is/are then occupying at least sixty-five percent (65%) of the Premises; and (ii) no uncured Event of Default exists (1) as of
the date of the Extension Notice (hereinafter defined), and (2) at the commencement of the applicable Extension Term (hereinafter defined), Tenant shall have the option (the “Extension Option”) to extend the Term for one
(1) additional term of ten (10) years (the“Extension Term”), commencing as of the expiration of the Initial Term. Tenant must exercise such option to extend, if at all, by giving Landlord written notice (the
“Extension Notice”) on or before the date that is twelve (12) months prior to the expiration of the Initial Term, time being of the essence. Upon the timely giving of such notice, the Term shall be deemed extended
upon all of the terms and conditions of this Lease, except that Base Rent during the Extension Term shall be calculated in accordance with this Section 1.2, Landlord shall have no obligation to construct or renovate the Premises, Landlord shall
have no obligation to provide any Landlord Contribution with respect to the Extension Term, and Tenant shall have no further right to extend the Term. If Tenant fails to give timely notice, as aforesaid, Tenant shall have no further right to extend
the Term. 
 Notwithstanding the fact that Tenant’s proper and timely exercise of such option to extend the Term shall be self-executing, the parties
shall promptly execute a lease amendment reflecting such Extension Term after Tenant exercises such option. The execution of such lease amendment shall not be deemed to waive any of the conditions to Tenant’s exercise of its rights under this
Section 1.2. 
 (b) The Base Rent during the Extension Term (the “Extension Term Base Rent”) shall be determined in
accordance with the process described hereafter. Extension Term Base Rent shall be the fair market rental value of the Premises then demised to Tenant as of the commencement of the Extension Term as determined in accordance with the process
described below, for renewals of first class office/research/laboratory building/campus in the Route 

  
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128/Route 2/Alewife corridor real estate market (the “Market Area”) of equivalent quality, size, utility and location, with the length of the Extension Term, the credit standing
of Tenant, any economic concessions (including, without limitation, tenant improvement allowances and free rent) then being provided by landlords to tenants, and all other relevant factors to be taken into account. Within thirty (30) days after
receipt of the Extension Notice, Landlord shall deliver to Tenant written notice of its determination of the Extension Term Base Rent for the Extension Term. Tenant shall, within thirty (30) days after receipt of such notice, notify Landlord in
writing whether Tenant accepts or rejects Landlord’s determination of the Extension Term Base 
 Rent (“Tenant’s Response
Notice”). If Tenant fails timely to deliver Tenant’s Response Notice, Landlord’s determination of the Extension Term Base Rent shall be binding on Tenant. 

(c) If and only if Tenant’s Response Notice is timely delivered to Landlord and indicates both that Tenant rejects Landlord’s
determination of the Extension Term Base Rent and desires to submit the matter to arbitration, then the Extension Term Base Rent shall be determined in accordance with the procedure set forth in this Section 1.2(c). In such event, within ten
(10) days after receipt by Landlord of Tenant’s Response Notice indicating Tenant’s desire to submit the determination of the Extension Term Base Rent to arbitration, Tenant and Landlord shall each notify the other, in writing, of
their respective selections of an appraiser (respectively, “Landlord’s Appraiser” and “Tenant’s Appraiser”). Landlord’s Appraiser and Tenant’s Appraiser shall then jointly select a
third appraiser (the “Third Appraiser”) within ten (10) days of their appointment. All of the appraisers selected shall be individuals with at least five (5) consecutive years’ commercial appraisal experience for
office and laboratory space in the area in which the Premises are located, shall be members of the Appraisal Institute (M.A.I.), and, in the case of the Third Appraiser, shall not have acted in any capacity for either Landlord or Tenant within five
(5) years of his or her selection. The three appraisers shall determine the Extension Term Base Rent in accordance with the requirements and criteria set forth in Section 1.2(b) above, employing the method commonly known as Baseball
Arbitration, whereby Landlord’s Appraiser and Tenant’s Appraiser each sets forth its determination of the Extension Term Base Rent as defined above, and the Third Appraiser must select one or the other (it being understood that the Third
Appraiser shall be expressly prohibited from selecting a compromise figure). Landlord’s Appraiser and Tenant’s Appraiser shall deliver their determinations of the Extension Term Base Rent to the Third Appraiser within five (5) days of
the appointment of the Third Appraiser and the Third Appraiser shall render his or her decision within ten (10) days after receipt of both of the other two determinations of the Extension Term Base Rent. The Third Appraiser’s decision
shall be binding on both Landlord and Tenant. Each party shall bear the cost of its own appraiser and the cost of the Third Appraiser shall be paid by the party whose determination is not selected. 

1.3 Appurtenant Rights. 

(a) Common Areas. Subject to the terms of this Lease and the Rules and Regulations (hereinafter defined), Tenant shall have, as
appurtenant to the Premises, rights to use in common with others entitled thereto, the following areas (such areas are hereinafter referred to as the “Common Areas”): (i) the common loading docks, hallways, lobby, and elevator of
the Building serving the Premises, (ii) the common lavatories located on the floor(s) on which the Premises are located, (iii) common walkways and driveways necessary for access to the Building, (iv) the Parking Areas, (v) other
areas and facilities located in the Building, on the 

  
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Land, or elsewhere on the Campus designated by Landlord from time to time for the common use of tenants of the Building and other entitled thereto; and (vi) Tenant shall have the right to
install mechanical equipment in the locations shown on Exhibits 5-1, 5-2, and 5-3, subject to Landlord’s prior
written approval of plans and specifications for any installations in such locations, which approval shall not be unreasonably withheld, conditioned or delayed; and no other appurtenant rights or easements. The three (3) loading docks,
receiving area, and freight elevators are available for the use of the tenants in the Building and are part of the Common Areas. 
 (b)
Parking. During the Term, Landlord shall, subject to the terms hereof, make available up to one hundred thirty-one (131) parking spaces for Tenant’s use free of charge (except that the costs
of maintenance and repair of the parking areas shall, subject to the provisions of Section 5.2, be included in Operating Costs) in the Parking Areas serving the Building, of which (x) three (3) parking spaces shall be designated for
visitor parking and located near the entrance of the Building and (y) three (3) parking spaces shall be designated for visitor parking and located in the adjacent Garage. The Parking Areas are currently as shown on Exhibit 3. The number
of parking spaces in the parking areas reserved for Tenant, as modified pursuant to this Lease or as otherwise permitted by Landlord, are hereinafter referred to as the “Parking Spaces.” Tenant shall have no right to hypothecate or
encumber the Parking Spaces, and shall not sublet, assign, or otherwise transfer the Parking Spaces other than to employees occupying the Premises of Tenant, of any Permitted Transferee (as defined in Section 13.7), and any other Transferee
pursuant to an approved Transfer under Section 13 of this Lease. Subject to Landlord’s right to reserve parking for other tenants of the Building, said Parking Spaces will be on an unassigned,
non-reserved basis, and shall be subject to such reasonable rules and regulations as may be in effect for the use of the parking areas from time to time. Reserved and handicap parking spaces must be honored.
Notwithstanding anything to the contrary contained herein, Landlord shall have the right, upon at least three (3) months’ written notice to Tenant, to temporarily relocate all or any portion of the Parking Spaces to other portions of the
Property and/or parking areas owned, controlled or leased by Landlord and located on the Campus or on Hayden Avenue in Lexington, MA. In addition, Landlord may, at its election, implement valet and tandem parking in order to accommodate the parking
needs of the Property from time to time. 
 (c) Cafeteria. 

(i) During the Term, Tenant, its employees, contractors, and visitors shall have the right to use the Cafeteria, as hereinafter
defined, in common with others entitled thereto. Notwithstanding anything to the contrary contained herein, during the Term, as the same may be extended hereby, Landlord shall be obligated to operate the Cafeteria, and Tenant shall be entitled to
use the same in accordance with this Section 1.3(c). The “Cafeteria” shall be defined as a food services facility which provides food to tenants and occupants of the Campus. As of the Execution Date: (i) the Cafeteria is
located in Building 55, and (ii) the normal operating hours of the Cafeteria are from 7:30 a.m. to 1:30 p.m., Monday through Friday, excepting holidays. Tenant hereby acknowledges that the Cafeteria may be relocated, from time to time, to other
buildings located on the Campus. A third party provider is currently contemplated to operate the Cafeteria. Any amounts paid by Landlord on account of the operation of the 

  
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Cafeteria in excess of the net revenues derived from the operation of the Cafeteria shall be included in Operating Costs, as shall all of Landlord’s costs of cleaning, maintaining, and
repairing the Cafeteria. Card readers shall, at no cost to Tenant, be installed and maintained at appropriate access points to the Cafeteria, and identification cards shall be issued to authorized users. 

(ii) In addition to the foregoing right to use the Cafeteria, Tenant shall have the right, up to four (4) times per
calendar year, to use the entire Cafeteria for so-called “all-hands company” meetings, subject to the following conditions: (a) Tenant shall give Landlord
at least fifteen (15) days’ prior written notice of any such meeting), (b) such use shall only occur during hours other than the Cafeteria’s normal operating hours, (c) each meeting shall occur on only one calendar day,
(d) such use of the Cafeteria by Tenant shall be subject to Cafeteria’s reasonable rules and regulations, (e) Tenant shall reimburse Landlord, as additional rent, for all of Landlord’s out-of-pocket costs (including, without limitation, janitorial services) incurred by Landlord as the result of such use of the Cafeteria, and (f) Tenant’s use of the Cafeteria shall be reasonably
coordinated by Landlord with other non-operating hour uses. 
 (d) Fitness Center. During the
Term, Tenant, its employees, and visitors shall have the right to use the Fitness Center, as hereinafter defined, in common with others entitled thereto. Notwithstanding anything to the contrary contained herein, during the Term, as the same may be
extended hereby, Landlord shall be obligated to operate the Fitness Center, and Tenant shall be entitled to use the same, in accordance with this Section 1.3(d). The “Fitness Center” shall be a
work-out facility for the use of tenants and occupants of the Campus. As of the Execution Date, the Fitness Center is located in the Building. Tenant acknowledges that the Fitness Center may be relocated, from
time to time, to other buildings located on the Campus. Card readers shall, at no cost to Tenant, be installed and maintained at appropriate access points to the Fitness Center, and identification cards shall be issued to authorized users. Users of
the fitness center shall be required to execute such liability waivers as Landlord shall reasonably require. Any amounts paid by Landlord on account of the operation of the Fitness Center in excess of any net revenues derived from the operation of
the Fitness Center shall be included in Operating Costs, as shall all of Landlord’s costs of cleaning, maintaining, and repairing the Fitness Center. 

1.4 Tenant’s Access.

(a) From and after the Term Commencement Date and until the end of the Term, Tenant shall have access to the Premises twenty-four
(24) hours a day, seven (7) days a week, subject to Landlord’s reasonable Building security requirements, causes beyond Landlord’s reasonable control, Legal Requirements, the Rules and Regulations, the terms of this Lease, Force
Majeure (hereinafter defined) and matters of record. 
 (b) Tenant and its employees shall have access to the Building after normal business
hours by means of a card reader access system. In addition to the foregoing, Tenant shall have the right, subject to Tenant’s obtaining Landlord’s prior written approval of Tenant’s plans and specifications therefor (which approval
shall not be unreasonably withheld, delayed or conditioned), to install a security system within the Premises (“Tenant’s Security System  

  
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Work”). Tenant’s Security System Work shall be performed in accordance with this Lease, including, without limitation, Section 11 hereof. Tenant shall provide Landlord and
the cleaning personnel with access cards permitting normal entry to Tenant’s Premises. In addition to the foregoing, such security system shall be designed with a master key override using the Building master key, so that Landlord shall have
access to the Premises in an emergency, but Landlord shall only use such master key access in an emergency. Additionally, Tenant shall ensure that such system shall comply with all applicable laws, rules and regulations, including all fire safety
laws, and in no event shall Landlord be liable for, and Tenant shall defend, indemnify, and hold harmless Landlord and its representatives and agents from and against, any claims, demands, liabilities, causes of action, suits, judgments, damages and
expenses arising from such system or the malfunctioning thereof in accordance with Tenant’s indemnity obligations set forth in Section 14.2. 

1.5 No recording // Notice of Lease. Neither party shall record this Lease. Tenant shall not record a memorandum of this Lease and/or a
notice of this Lease. Notwithstanding the foregoing, if the Initial Term plus any Extension Term(s) exceed in the aggregate seven (7) years, Landlord agrees to join in the execution, in recordable form, of a statutory notice of lease and/or
written declaration in which shall be stated the Term Commencement Date, the Rent Commencement Date, the number and length of the Extension Term(s) and the Expiration Date, which notice of lease may be recorded by Tenant with the Middlesex South
Registry of Deeds and/or filed with the Middlesex South Registry District of the Land Court, as appropriate (alternatively and collectively, the “Registry”) at Tenant’s sole cost and expense. If a notice of lease was previously
recorded with the Registry, upon the expiration or earlier termination of this Lease, Landlord shall deliver to Tenant a notice of termination of lease and Tenant shall promptly execute, acknowledge, and deliver the same (together with any other
instrument(s) that may be necessary in order to record and/or file same with the Registry) to Landlord for Landlord’s execution and recordation with the Registry, which obligation shall survive the expiration or earlier termination of the
Lease. 
 1.6 Exclusions. The following are expressly excluded from the Premises and reserved to Landlord: all the perimeter walls of
the Premises (except the inner surfaces thereof), the Common Areas, and any space in or adjacent to the Premises used for shafts, stacks, pipes, conduits, wires and appurtenant fixtures, fan rooms, ducts, electric or other utilities, sinks or other
Building facilities, and the use of all of the foregoing, except as expressly permitted pursuant to Section 1.3(a) above. 
 1.7
Acid Neutralization Tank.
 (a) There currently exists an acid neutralization tank (the “Acid
Neutralization Tank”) that is located in the PH System Room on the first (1st) floor of the Building. Tenant acknowledges and agrees that Tenant is leasing the Acid Neutralization
Tank in its “AS IS,” “WHERE IS” condition and with all faults on the Execution Date, without representations or warranties, express or implied, in fact or by law, of any kind, or recourse to Landlord. Tenant shall have the
exclusive right, throughout the Term of the Lease, as the same may be extended, to use the Acid Neutralization Tank in accordance with Legal Requirements. Tenant shall obtain, and maintain all governmental permits and approvals necessary for the
operation and maintenance of the Acid Neutralization Tank. Tenant shall be responsible for all 

  
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costs, charges and expenses incurred from time to time in connection with or arising out of the operation, use, maintenance, repair or refurbishment of the Acid Neutralization Tank, including all
clean-up costs relating to the Acid Neutralization Tank (collectively, “Tank Costs”), except, subject to Section 14.5, to the extent such costs are caused by the negligence or willful
misconduct of any of the Landlord Parties. 
 Notwithstanding the foregoing, Landlord shall: (i) prior to delivering the Acid
Neutralization Tank and PH Premises to Tenant, cause the tenant currently using the Acid Neutralization Tank and the PH Premises to decommission the same in accordance with the provisions of Section 21(b) of this Lease, and (ii) cause the
Acid Neutralization Tank to be in operating order at the time that the Acid Neutralization Tank is delivered to Tenant. Tenant shall be responsible for assuring that the maintenance and operation of the Acid Neutralization Tank shall in no way
damage any portion of the Building or Property. To the maximum extent permitted by Law, the Acid Neutralization Tank and all appurtenances thereto shall be at the sole risk of Tenant, and Landlord shall have no liability to Tenant if the Acid
Neutralization Tank or any appurtenant installations are damaged for any reason. Except for any Landlord Parties’ negligence or willful misconduct, Tenant agrees to be responsible for any damage caused to the Building or Property in connection
with the, maintenance and operation of the Acid Neutralization Tank. This indemnification by Tenant includes costs actually incurred by Landlord: (1) in connection with any investigation required by any governmental authority of site conditions
to the extent resulting from the breach by Tenant of its obligations with respect to the Acid Neutralization Tank, (2) in connection with any investigation required by Landlord pursuant to which it is determined that Tenant has breach its
obligations with respect to the Acid Neutralization Tank, and (3) any clean-up, remediation, and/or removal of any Hazardous Materials and/or restoration of the Property required by any governmental
authority caused by Tenant’s improper use of the Acid Neutralization Tank. 
 (b) Tenant shall be responsible for the operation,
cleanliness, and maintenance of the Acid Neutralization Tank and the appurtenances, all of which shall remain the personal property of Landlord, and shall be left in place by Tenant at the expiration or earlier termination of the Lease. Such
maintenance and operation shall be performed in a manner to avoid any unreasonable interference with any other tenants or Landlord. Tenant shall take the Acid Neutralization Tank “as is” in the condition in which the Acid Neutralization
Tank Premises is in as of the Commencement Date, without any obligation on the part of Landlord to prepare or construct the PH System Premises for Tenant’s use or occupancy. Without limiting the foregoing, Landlord makes no warranties or
representations to Tenant as to the suitability of the Acid Neutralization and the PH System Premises for the operation of the Acid Neutralization Tank. Tenant shall have no right to make any changes, alterations, additions, decorations or other
improvements to the PH System Premises without Landlord’s prior written consent which shall not be unreasonably withheld, conditioned or delayed. Tenant agrees to maintain the Acid Neutralization Tank in good condition and repair. Landlord
shall have no obligation to provide any services, including, without limitation, electric current, to the Acid Neutralization Tank. 

1.8 Standby Power. Reference is made to the facts that: (i) the Building is served by a 400 kw 480/277 3 phase 4 wire
(“Existing Generator Capacity”) emergency generator (the “Existing Generator”), and (ii) the Existing Generator provides standby power for certain tenants of the Building as well as support for the
common life safety systems of the Building. 

  
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Tenant shall have the right, subject to obtaining Landlord’s prior written approval, which approval shall not be unreasonably withheld, to connect its equipment in the Premises to the
Existing Generator, provided that the aggregate electrical demand of all equipment connected by Tenant to the Existing Generator at any time shall not exceed (i) 105 kilowatts for the North Premises, 120 kw/208v 3 phase 4 wire, (ii) 50 kilowatts for
the South Premises, 120 kw/208v 3 phase 4 wire, and (iii) 135 kilowatts for the Expansion Premises, 120 kw/208v 3 phase 4 wire. Landlord’s sole obligation to Tenant with respect to the Existing Generator shall be to contract with a reputable
third party (“Generator Servicer”) to maintain the Existing Generator as per the manufacturer’s standard maintenance guidelines. Landlord shall have no obligation to supervise, oversee or confirm that the Generator Servicer is
maintaining the Existing Generator per the manufacturer’s standard guidelines or otherwise, and Landlord shall have no obligation or liability to Tenant in the event that the Existing Generator is not operational. 

 

	2.	 RIGHTS RESERVED TO LANDLORD 

2.1 Additions and Alterations. Landlord reserves the right, at any time and from time to time, to make such changes, alterations,
additions, improvements, repairs or replacements in or to the Property (including the Premises but, with respect to the Premises, only for purposes of repairs, maintenance, replacements and the exercise of any other rights expressly reserved to
Landlord herein) and the fixtures and equipment therein, as well as in or to the street entrances and/or the Common Areas, as it may deem necessary or desirable, provided, however, that there be no material obstruction of permanent access to, or
material interference with the use and enjoyment of, the Premises by Tenant. Subject to the foregoing, Landlord expressly reserves the right to temporarily close all, or any portion, of the Common Areas for the purpose of making repairs or changes
thereto. 
 2.2 Additions to the Property.

(a) Landlord may at any time or from time to time (i) construct additional building(s) and improvements and related site improvements
(collectively, “Future Development”) in all or any part of the Property and/or (ii) change the location or arrangement of any improvement outside the Building in or on the Property or all or any part of the Common
Areas, or add or deduct any land to or from the Property; provided that there shall be no material increase in Tenant’s obligations or material interference with Tenant’s rights under this Lease in connection with the exercise of the
foregoing reserved rights. 
 (b) In case any excavation shall be made for building or improvements or for any other purpose upon the land
adjacent to or near the Premises, Tenant will afford without charge to Landlord, or the person or persons, firms or corporations causing or making such excavation, license to enter upon the Premises for the purpose of doing such work as Landlord or
such person or persons, firms or corporation shall deem to be necessary to preserve the walls or structures of the Building from injury, and to protect the Building by proper securing of foundations. 

  
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 (c) Tenant acknowledges and agrees that this Lease is subject and subordinate to
(i) The Hayden Science Center Condominium (“Condominium”), which was established by Master Deed dated December 1, 2017, recorded in Book 70325, Page 108, in the Middlesex South District Registry of Deeds and filed as
Document No. 195793 in the Middlesex South Registry District of the Land Court, (ii) the Condominium Floor Plans and Site Plans dated December 1, 2017, and filed with the Middlesex Registry of Deeds, Southern District, as Plan
No. 1090, Pages 1 through 13, and (iii) the Declaration of Trust of The Hayden Science Center Condominium Trust dated December 1, 2017, recorded in Book 70325, Page 148, in the Middlesex South District Registry of Deeds and filed as
Document No. 195794 in the Middlesex South Registry District of the Land Court (the Master Deed, Declaration of Trust, and the Plans are being referred to herein as the “Condominium Documents”). Tenant agrees that
the Condominium Documents may be amended and that this Lease shall remain subject to and subordinate to the Condominium Documents, as so amended, so long as such amendments do not: (x) materially adversely affect Tenant’s rights under this
Lease, or (y) materially increase Tenant’s obligations under this Lease. Landlord agrees to provide Tenant with copies of any such amendments at least ten (10) business days prior to recording same. 

(d) Landlord and Tenant each hereby acknowledges and agrees that, in connection with any Future Development, (i) Landlord shall have the
right to enter into, and subject the Property to the terms and conditions of, a commercially reasonable reciprocal easement agreement with any one or more of the neighboring property owners in order to create a commercial campus-like setting
(“REA”); (ii) upon Landlord’s request in connection with the recording of the REA, Tenant shall execute a commercially reasonable instrument in recordable form making this Lease subject and subordinate to the REA;
(iii) Landlord shall have the right to subdivide the Property so long as Tenant continues to have all of the rights and obligations contained in this Lease (e.g., the appurtenant right to use all Common Areas); and (iv) Tenant shall
execute such reasonable documents (which may be in recordable form) evidencing the foregoing promptly upon Landlord’s request, so long as such agreements do not (x) materially adversely affect Tenant’s rights under this Lease or
(y) materially increase Tenant’s obligations under this Lease. Landlord agrees to provide Tenant with copies of any such agreements at least ten (10) business days prior to recording same. 

2.3 Name and Address of Building. Landlord reserves the right at any time and from time to time to change the name or address of
the Building and/or the Property, provided Landlord gives Tenant at least three (3) months’ prior written notice thereof. 

2.4 Landlord’s Access.

(a) Premises. Subject to the terms hereof, Tenant shall upon reasonable advance notice (not less than twenty-four (24) hours),
which may be by e-mail at jeffrey.moore@kaleido.com with a copy to allison.angelico@kaleido.com or some other email address as may be provided in writing by Tenant to Landlord (except that no notice shall be
required in emergency situations): (a) permit Landlord and any holder of a Mortgage (hereinafter defined) (each such holder, a “Mortgagee”), and the agents, representatives, employees and contractors of each of them, to have
reasonable access to the Premises at all reasonable hours for the purposes of inspection, making repairs, replacements or improvements in or to the Premises or the Building or equipment therein (including, without limitation, sanitary, electrical,
heating, air conditioning or other systems), complying with all applicable laws, ordinances, rules, regulations, statutes, by-laws, court decisions and orders and requirements of all public authorities
(collectively, “Legal Requirements”), or exercising any 

  
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right reserved to Landlord under this Lease (including without limitation the right to take upon or through, or to keep and store within the Premises all necessary materials, tools and
equipment); (b) permit Landlord and its agents and employees to show the Premises during normal business hours (i.e. Monday – Friday 7 A.M. – 6 P.M., Saturday 7 A.M. – 12 P.M., excluding holidays) to any prospective Mortgagee or
purchaser of the Building and/or the Property or of the interest of Landlord therein, and, during the last twelve (12) months of the Term or at any time after the occurrence of an Event of Default, prospective tenants; and (c) permit
Landlord and its agents, at Landlord’s sole cost and expense, to perform environmental audits, environmental site investigations and environmental site assessments (“Site Assessments”) in, on, under and at the Premises
and the Land, it being understood that Landlord shall repair any damage arising as a result of the Site Assessments, and such Site Assessments may include both above and below the ground testing and such other tests as may be necessary or
appropriate to conduct the Site Assessments. In addition, to the extent that it is necessary to enter the Premises in order to access any area that serves any portion of the Building outside the Premises, then Tenant shall, upon as much advance
notice as is practical under the circumstances, and in any event at least twenty-four (24) hours’ prior written notice (except that no notice shall be required in emergency situations), permit contractors engaged by other occupants of the
Building to pass through the Premises in order to access such areas but only if accompanied by a representative of Landlord. Notwithstanding anything to the contrary contained herein, Tenant shall be entitled to have a representative present for any
access by Landlord or any Landlord Parties in exercising its rights under this Section 2.4. 
 (b) Secure Area within the
Premises. Notwithstanding the foregoing, Tenant, at its own expense may, as hereinafter set forth, designate one or more areas of the Premises to be “Secure Areas” (i.e., portions of the Premises to which Landlord shall
not have a right of entry or access for any reason whatsoever (except as otherwise provided below). Tenant may, from time to time, exercise its right to create Secure Areas by delivering to Landlord, for Landlord’s written approval, a plan
showing the location of any such Secure Areas. Landlord agrees that it will not unreasonably withhold, condition or delay such consent. If Landlord must gain access to a Secure Areas in a non-emergency
situation, Landlord shall contact Tenant, and Landlord and Tenant shall arrange a mutually agreed upon time for Landlord to have such access. Landlord shall be accompanied by an employee of Tenant or a party designated by Tenant (the
“Escort”). Tenant shall make an Escort available to Landlord during business hours. At all times, Landlord shall comply with all reasonable security measures of the Tenant pertaining to the Secure Areas. If an emergency representing
an imminent risk of injury to persons or material property damage in the Building or the Premises, including, without limitation, a suspected fire or flood, requires Landlord to gain access to the Secure Areas, Landlord may enter the Secure Areas
without an Escort. If practicable under the circumstances, Landlord shall immediately notify (which may be oral notification) and request that Tenant make an Escort available to Landlord if time permits, and if Tenant shall not make an Escort
available to accompany Landlord, then Tenant hereby authorizes Landlord to enter the Secure Areas forcibly or with a master key, and to enter without an Escort. In any such event, except (subject to Section 14.5 of this Lease) to the extent
resulting from Landlord’s negligence or willful misconduct, Landlord shall have no liability whatsoever to Tenant, and Tenant shall pay all reasonable expenses incurred by Landlord in repairing or reconstructing any entrance, corridor, door or
other portions of the Premises damaged as a result of a forcible entry by Landlord. Landlord shall have no obligation to provide either janitorial service or cleaning in the Secure Areas unless Tenant shall make arrangements to have an Escort in the
Secure Areas at the time such service or cleaning is provided to the remainder of the Premises. 

  
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 2.5 Pipes, Ducts and Conduits. Tenant shall permit Landlord to erect, use,
maintain and relocate pipes, ducts and conduits in and through the Premises, provided the same do not reduce the rentable square footage of the Premises, other than in a de minimis amount, or adversely affect the appearance of the Premises. In
exercising its rights under this Section 2.5, Landlord shall make commercially reasonable efforts to locate any pipes, ducts, and conduits behind walls and above ceilings so as to minimize interference with the Premises. 

2.6 Minimize Interference. Except in the event of an emergency, Landlord shall use commercially reasonable efforts to minimize
any interference with Tenant’s business operations and use and occupancy of the Premises in connection with the exercise any of the foregoing rights under this Section 2. 

 

	3.	 CONDITION OF PREMISES; CONSTRUCTION. 

3.1 Condition of Premises. Tenant acknowledges and agrees that Tenant is leasing the Premises in their “AS IS,”
“WHERE IS” condition and with all faults on the Execution Date, without representations or warranties, express or implied, in fact or by law, of any kind, and without recourse to Landlord, except that Landlord shall:
(i) perform Landlord’s North Premises Work and Landlord’s South Premises Work, and (ii) provide Landlord’s North Premises Contribution and Landlord’s South Premises Contributions, all in accordance with the provisions
of Exhibit 4. 
 3.2 Landlord’s Work. 

(a) Subject to Force Majeure, as defined in Section 25.16 and any Tenant Delay, as hereinafter defined, Landlord shall perform
Landlord’s North Premises Work and Landlord’s South Premises Work (as said terms are hereinafter defined, Landlord’s North Premises Work and Landlord’s South Premises Work being sometimes collectively referred to herein as
“Landlord’s Work”), in order to prepare the North Premises and the South Premises, respectively, for Tenant’s use and occupancy in accordance with Exhibit 4 attached hereto. Landlord shall use diligent efforts to
substantially complete Landlord’s North Premises Work by September 1, 2018 (the “Estimated North Premises Term Commencement Date”), and Landlord shall use diligent efforts to substantially complete
Landlord’s South Premises Work by October 1, 2018 (“Estimated South Premises Term Commencement Date”). However, except for Tenant’s remedies set forth in Sections 3.3 and 3.4 hereof:
(i) Tenant’s sole remedy in the event of a delay in Landlord’s North Premises Work shall be a delay in the North Premises Term Commencement Date, (ii) Tenant’s sole remedy in the event of a delay in Landlord’s South
Premises Work shall be a delay in and South Premises Term Commencement Date, (iii) Tenant shall have no claim or rights against Landlord, and Landlord shall have no liability or obligation to Tenant in the event of delay of either the
Landlord’s North Premises Work or of Landlord’s South Premises Work, and (iii) no delay in Landlord’s North Premises Work and/or South Premises Work shall have any effect on the parties rights or obligations under this Lease.

  
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 (b) Definitions. 

(i) “Tenant Delay” shall mean any act or omission by Tenant and/or Tenant’s agents, employees or
contractors (collectively with Tenant, the “Tenant Parties”) which causes an actual delay in the performance of Landlord’s Work. Notwithstanding the foregoing, except where a Tenant Delay arises from Tenant’s
failure timely to act within on or before a date or time period expressly set forth in the Lease (in which event no Tenant Delay Notice shall be required): (x) in no event shall any act or omission be deemed to be a Tenant Delay until and unless
Landlord has given Tenant written notice (the “Tenant Delay Notice”) advising Tenant (a) that a Tenant Delay is occurring, and (b) of the basis on which Landlord has determined that a Tenant Delay is
occurring, and (y) no period of time prior to the time that Tenant receives a Tenant Delay Notice shall be included in the period of time charged to Tenant pursuant to such Tenant Delay Notice. 

(ii) “Substantially Complete” or “Substantial Completion,” when
referring to either portion of Landlord’s Work shall mean that: (1) such portion of Landlord’s Work is completed, other than minor work which does not materially affect Tenant’s use of, or access to, the North Premises or South
Premises, as applicable, (2) the Premises and those portions of the Common Areas of the Building which affect Tenant’s occupancy are in conformance with all applicable building codes, permits, laws and regulations, including without
limitation, ADA, (3) all structural elements and subsystems of the Building, including but not limited to HVAC, mechanical, electrical, lighting, plumbing, and life safety systems, will be in good working condition and repair, (4) Landlord
has delivered to Tenant a certificate of substantial completion from Landlord’s architect stating that such portion of Landlord’s Work is substantially complete, and (5) such evidence (the “Town Approval”) as
is customarily provided by the Town of Lexington to evidence its acceptance of such portion of Landlord’s Work and Tenant’s right to lawfully occupy the North Premises and South Premises, as applicable, (e.g., sign-offs on the Building
permit by all applicable Town of Lexington departments or a certificate of occupancy, which may be a temporary certificate of occupancy) has been provided by the Town of Lexington. No costs incurred by Landlord in satisfying the definition of
Substantial Completion shall be included in Operating Costs. Notwithstanding anything to the contrary herein contained, in the event that either portion of Landlord’s Work is delayed by reason of any Tenant Delay, then Landlord shall be deemed
to have achieved Substantial Completion of such portion of Landlord’s Work on the date that Landlord would have achieved Substantial Completion of such portion of Landlord’s Work, but for such Tenant Delay. 

(iii) Punchlist. Promptly following Substantial Completion of either portion Landlord’s Work, Landlord shall
provide Tenant with a punchlist prepared by Landlord’s architect (the “Punchlist”) incorporating those items jointly identified by Landlord and Tenant during their joint inspection of such portion of Landlord’s Work, of
outstanding items (the “Punchlist Items”). Promptly after Substantial Completion of either portion of Landlord’s Work, Landlord and Tenant shall jointly inspect the North Premises and/or South Premises, as
applicable. Subject to Landlord’s Force Majeure and Tenant Delays, Landlord shall complete all Punchlist Items within thirty (30) days of the date of the Punchlist (other than seasonal items, such as landscaping, requiring a longer
period), provided that Tenant reasonably cooperates in connection with the completion of such Punchlist Items. 

  
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 3.3 Tenant’s Remedies in the Event of Delays in North Premises Term
Commencement Date. The provisions of this Section 3.3 set forth Tenant’s sole remedies, both at law and in equity, in the event of any delay in Landlord’s North Premises Work or in the North Premises Term Commencement Date.

 (a) Rent Credit. In the event that the North Premises Term Commencement Date does not occur on or before the North Premises Rent
Credit Date, as hereinafter defined, Tenant shall be entitled to a rent credit against Tenant’s obligation to pay Annual Base Rent following the North Premises Term Commencement Date equal to $5,750.21 for each day between the North Premises
Rent Credit Date and the North Premises Term Commencement Date. The “North Premises Rent Credit Date” shall be defined as the date thirty (30) days after the Estimated North Premises Term Commencement Date, except
that the North Premises Rent Credit Date shall be extended by the length of any delay in the performance of Landlord’s North Premises Work arising from Force Majeure, provided that in no event shall the North Premises Rent Credit Date be later
than the date sixty (60) days after the Estimated North Premises Term Commencement Date. 
 (b) Tenant’s Termination Right.
If the North Premises Term Commencement Date does not occur on or before the Outside Termination Date, as hereinafter defined, then Tenant shall have the right to terminate this Lease, which shall be exercisable by a written thirty-(30)-day termination notice given on or after the Outside Termination Date but before the date that the North Premises Term Commencement Date occurs. If the North Premises Term Commencement Date occurs on or
before the thirtieth (30th) day after Landlord receives such termination notice, Tenant’s termination notice shall be deemed to be void and of no force or effect. If the North Premises Term Commencement Date does not occur on or before such
thirtieth (30th) day, this Lease shall terminate and shall be of no further force or effect, and, except for provisions of the Lease which are intended to survive termination of the Lease (e.g., indemnification provisions), Landlord shall promptly
refund to Tenant any Security Deposit paid by Tenant to Landlord, and neither party shall have any further obligation to the other party. For the purposes hereof, the “Outside Termination Date” shall be defined as the date
four (4) months after the Estimated North Premises Term Commencement Date, except that the Outside Termination Date shall be extended by the length of any delay in the performance of Landlord’s North Premises Work arising from Force
Majeure, provided that in no event shall the Outside Termination Date be later than the date six (6) months after the Estimated North Premises Term Commencement Date. 

3.4 Tenant’s Remedy in the Event of Delays in South Premises Term Commencement Date. The provisions of this
Section 3.4 set forth Tenant’s sole remedy, both at law and in equity, in the event of any delay in Landlord’s South Premises Work or in the South Premises Term Commencement Date. In the event that the South Premises Term Commencement
Date does not occur on or before the South Premises Rent Credit Date, as hereinafter defined, Tenant shall be entitled to a rent credit against Tenant’s obligation to pay Annual Base Rent following the South Premises Term Commencement Date
equal to $1,951.98 for each day between the South Premises Rent Credit Date, as hereinafter defined, and the South 

  
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Premises Term Commencement Date. The “South Premises Rent Credit Date” shall be defined as the date thirty (30) days after the Estimated South Premises Term
Commencement Date, except that the South Premises Rent Credit Date shall be extended by the length of any delay in the performance of Landlord’s South Premises Work arising from Force Majeure, provided that in no event shall the South Premises
Rent Credit Date be later than the date sixty (60) days after the Estimated South Premises Term Commencement Date. 
  

	4.	 USE OF PREMISES 

4.1 Permitted Uses. During the Term, Tenant shall use the Premises only for the Permitted Uses and for no other purposes. Service
and utility areas (whether or not a part of the Premises) shall be used only for the particular purpose for which they are designed. Tenant shall keep the Premises equipped with appropriate safety appliances to the extent required by applicable laws
or insurance requirements. Landlord shall cooperate with Tenant, in such manner as Tenant may reasonably request, in assisting Tenant to obtain any governmental permits or approvals necessary to enable Tenant to use the Premises for any of the
Permitted Uses, provided that Landlord shall not be obligated to incur any out-of-pocket costs or expenses or incur any liability in connection with any such request.

 4.2 Prohibited Uses. 

(a) Notwithstanding any other provision of this Lease, Tenant shall not use the Premises or the Building, or any part thereof, or suffer or
permit the use or occupancy of the Premises or the Building or any part thereof by any of the Tenant Parties (i) in a manner which would violate any of the covenants, agreements, terms, provisions and conditions of this Lease or otherwise
applicable to or binding upon the Premises; (ii) for any unlawful purposes or in any unlawful manner; (iii) which, in the reasonable judgment of Landlord (taking into account the use of the Building as a combination laboratory, research
and development and office building and the Permitted Uses) shall (a) impair, interfere with or otherwise diminish the quality of any of the Building services or the proper and economic heating, cleaning, ventilating, air conditioning or other
servicing of the Building or Premises, or the use or occupancy of any of the Common Areas; (b) occasion impairment, interference or injury in any material respect (and Tenant shall not install or use any electrical or other equipment of any
kind, which, in the reasonable judgment of Landlord, will cause any such impairment, interference, or injury), or cause any injury or damage to any occupants of the Premises or other tenants or occupants of the Building or their property; or
(c) cause harmful air emissions, laboratory odors or noises or any unusual or other objectionable odors, noises or emissions to emanate from the Premises; (iv) in a manner which is inconsistent with the operation and/or maintenance of the
Building as a first-class combination office, research, development and laboratory facility; or (v) in a manner which shall increase such insurance rates on the Building or on property located therein over that applicable when Tenant first took
occupancy of the Premises hereunder. Notwithstanding the foregoing, Landlord agrees that Tenant’s use of the Premises for the Permitted Use (as opposed to the particular manner of Tenant’s use of the Premises) shall not, in and of itself,
be deemed to breach the provisions of this Section 4.2. 

  
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 (b) With respect to the use and occupancy of the Premises and the Common Areas, Tenant will
not: (i) place or maintain any signage (except as set forth in Section 12.2 below), trash, refuse or other articles in any vestibule or entry of the Premises, on the footwalks or corridors adjacent thereto or elsewhere on the exterior of
the Premises, nor obstruct any driveway, corridor, footwalk, parking area, mall or any other Common Areas; (ii) permit undue accumulations of or burn garbage, trash, rubbish or other refuse within or without the Premises; (iii) permit the
parking of vehicles so as to interfere with (x) the ability of others, entitled thereto, to park in the common parking areas, or (y) the use of any driveway, corridor, footwalk, parking area, or other Common Areas; (iv) receive or
ship articles of any kind outside of those areas reasonably designated by Landlord; (v) conduct or permit to be conducted any auction, going out of business sale, bankruptcy sale (unless directed by court order), or other similar type sale in
or connected with the Premises; (vi) use the name of Landlord, or any of Landlord’s affiliates in any publicity, promotion, trailer, press release, advertising, printed, or display materials without Landlord’s prior written consent;
or (vii) except in connection with Alterations (hereinafter defined) approved by Landlord, cause or permit any hole to be drilled or made in any part of the Building. 

4.3 MWRA Permit. Tenant shall establish and maintain with respect to its use of wastewater facilities exclusively serving the Leased
Premises, an MWRA waste water discharge program administered by a licensed, qualified individual (which individual may be (i) a third party contractor/consultant approved by Landlord, which approval shall not be unreasonably withheld, or
(ii) an employee of Tenant or Tenant’s affiliate) in accordance with the requirements of the Massachusetts Water Resources Authority (“MWRA”) and any other applicable governmental authority. Tenant shall be
solely responsible for all costs incurred in connection with such MWRA waste water discharge, and Tenant shall provide Landlord with such documentation as Landlord may reasonably require evidencing Tenant’s compliance with the
requirements of (a) the MWRA and any other applicable governmental authority with respect to such chemical safety program and (b) this Section. Tenant shall obtain and maintain during the Term (i) any permit required by the MWRA
(“MWRA Permit”) and (ii) a wastewater treatment operator license from the Commonwealth of Massachusetts with respect to Tenant’s use of any acid neutralization tank exclusively serving the Leased Premises in
the Building. Tenant shall not introduce anything into the acid neutralization tank serving the Premises, if any (x) in violation of the terms of the MWRA Permit, (y) in violation of Legal Requirements or (z) that would interfere with
the proper functioning of any such acid neutralization tank. 
 4.4 Parking and Traffic Demand Management Plan. The Property is
subject to a Parking and Traffic Demand Management Plan with the Town of Lexington (the “Initial PTDM”). Tenant agrees, at its sole expense, to comply with the requirements of the Initial PTDM, only insofar as they apply to the
Premises and/or Tenant’s use and occupancy thereof. In the event that the Initial PTDM is ever modified, supplemented, amended or replaced (“PTDM Modifications”), Tenant agrees, at its sole expense, to comply with
the requirements of the PTDM Modifications, only insofar as they apply to the Premises and/or Tenant’s use and occupancy thereof.  

  
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	5.	 RENT; ADDITIONAL RENT 

5.1 Base Rent. Commencing as of the respective Base Rent Commencement Dates for the North Premises and for the South Premises and
continuing thereafter throughout the remainder of the Term, Tenant shall pay Base Rent to Landlord with respect to each portion of 
 the Premises in equal
monthly installments, in advance and without demand on the first day of each month for and with respect to such month. Commencing as of the respective Additional Rent Commencement Dates for the North Premises and for the South Premises, Tenant shall
pay Tenant’s Share of Operating Costs, Tenant’s Share of Taxes, and utility costs with respect to each portion of the Premises (collectively, “Additional Rent”) to Landlord in accordance with this Section 5. Base Rent
shall be pro-rated for any partial months. For purposes of this Lease, Base Rent, Additional Rent and other charges reserved and covenanted to be paid under this Lease with respect to the Premises shall be
known collectively as “Rent”. Rent shall be payable to Landlord or, if Landlord shall so direct in writing, to Landlord’s agent or nominee, in lawful money of the United States which shall be legal tender for payment of all
debts and dues, public and private, at the time of payment. 
 5.2 Operating Costs. 

(a) “Operating Costs” shall mean all costs incurred and expenditures of whatever nature made by Landlord in the
operation, management, repair, replacement, maintenance and insurance (including, without limitation, environmental liability insurance and property insurance on Landlord-supplied leasehold improvements for tenants, but not property insurance on
tenants’ equipment) of the Property or allocated to the Property, including without limitation all costs of labor (wages, salaries, fringe benefits, etc.) up to and including the Property manager, however denominated, any costs for utilities
supplied to exterior areas and the Common Areas, and any costs for repair and replacements, cleaning and maintenance of exterior areas and the Common Areas, related equipment, facilities and appurtenances and HVAC equipment, security services, a
management fee in the amount of four percent (4%) of gross Building revenues (increased, if applicable, in accordance with Section 5.2(f)), the costs (“Management Office Costs”), including, without limitation, a
commercially reasonable rental factor, of Landlord’s management office for the Property, which management office may be located outside the Property and which may serve other properties in addition to the Property (in which event such costs
shall be equitably allocated among the properties served by such office), the cost of operating any amenities in the Property available to all tenants of the Property and any subsidy provided by Landlord for or with respect to any such amenity. For
costs and expenditures made by Landlord in connection with the operation, management, repair, replacement, maintenance and insurance of the Building as a whole, Landlord shall make a reasonable allocation thereof between the retail and non-retail portions of the Building, if applicable. Prior to the creation of the Condominium in accordance with Section 2.2, Landlord shall allocate Operating Costs which are incurred with respect to the Common
Areas of the Campus on a reasonable basis. Since the Garage located on the Land is for the exclusive benefit of the tenants of the Building, all Operating Costs incurred by Landlord with respect to the Garage shall be allocated to the Property.
After the creation of the Condominium, such allocation shall be made in accordance with the Condominium Documents establishing the Condominium. Operating Costs shall not include Excluded Costs (hereinafter defined). 

(b) “Excluded Costs” shall be defined as (i) any fixed or percentage ground rent payable to any ground lessor, or any
mortgage charges (including interest, principal, points and fees) and any debt service costs (provided however, that the provisions of this clause (i) shall not be deemed to exclude mortgage charges and debt service costs incurred with respect
to Permitted Capital Expenditures, as hereinafter defined, from Operating Costs); (ii) brokerage 

  
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commissions, marketing costs, concessions and leasehold improvement costs incurred in connection with the leasing of any rentable space at the Building or Campus including, without limitation,
finders’ fees, attorneys’ fees and expenses, entertainment costs and travel expenses; (iii) salaries and bonuses and benefits of officers, executives of Landlord and administrative employees above the grade of Director of Property
Management; (iv) the cost of work done by Landlord for a particular tenant or any special work or service performed for any tenant (including Tenant) billable to such tenant or any costs in connection with services or benefits that are provided
to or for the particular benefit of other tenants but not offered to Tenant; (v) the cost of items which, by generally accepted accounting principles, would be capitalized on the books of Landlord or are otherwise not properly chargeable
against income, except to the extent such capital item is (A) required by any Legal Requirements following the Execution Date of this Lease, or (B) reasonably projected to reduce Operating Costs (collectively, “Permitted
Capital Expenditures”); (vi) the costs of Landlord’s Work and any contributions made by Landlord to any tenant of the Property in connection with the build-out of its premises;
(vii) franchise or income taxes imposed on Landlord; (viii) costs paid directly by individual tenants to suppliers, including tenant electricity, telephone and other utility costs; (ix) increases in premiums for insurance when such
increase is caused by the use of the Building by Landlord or any other tenant of the Building; (x) depreciation of the Building; (xi) costs relating to maintaining Landlord’s existence as a corporation, partnership or other entity;
(xii) attorneys’ fees incurred in connection with lease negotiations, disputes with individual tenants and/or for the existence, maintenance or non-Building or Campus related operations of the legal
entity or entities of which Landlord is comprised or the development of additional space at the Building or Campus; (xiii) the cost of any items for which Landlord may be reimbursed by condemnation awards, refund, rebate or otherwise, and any
expenses for repairs or maintenance to the extent covered by warranties, guaranties and service contracts; (xiv) costs incurred in connection with any disputes between Landlord and its employees, between Landlord and Building management, or
between Landlord and other tenants or occupants, (xv) Taxes; (xvi) the cost of any repairs or restoration required because of fire, other casualty or taking, provided, however, that Operating Costs may include costs of repairs which are not
covered because the cost of such repairs is within a commercially reasonable deductible carried under Landlord’s casualty insurance policy (Tenant hereby agreeing that, as of the Execution Date, $25,000.00 is a commercially reasonable
deductible, (xvii) management and administrative fees, other than as provided in Section 5.2(a) above; (xviii) the cost of remediating Hazardous Materials from the Building or the Campus other than Included Hazardous Materials, as
hereinafter defined; “Included Hazardous Materials” shall be defined as all Hazardous Materials, other than: (A) any material or substance located in the Building or the Property on the Execution Date which, as of
the Execution Date, is not considered under then existing Legal Requirements, to be Hazardous Material, but which is subsequently determined to be a Hazardous Material by reason of a Legal Requirement which first becomes effective after the
Execution Date of this Lease, and (B) any material or substance that is introduced to the Building or the Property after the Execution Date which, when introduced to the Building or the Property, is not then (i.e., at the time of introduction
to the Building or the Property) considered, as a matter of any Legal Requirement, to be a Hazardous Material, but which is subsequently determined to be a Hazardous Material by reason of Legal Requirements which first becomes effective after the
date of introduction of such material or substance to the Building or Property; (xix) any cost covered by a warranty that Landlord is required to obtain in connection with the Building or the Land; (xx) any amounts 

  
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paid to a person, firm, corporation or other entity under common ownership and control with Landlord that is in excess of a commercially reasonable amount paid on a market rate basis (other than
management fees); (xxi) the cost of acquiring sculptures, paintings, and other objects of art; (xxii) depreciation of the Building or Campus or any part thereof (provided however, that the provisions of this clause (xxii) shall not be
deemed to exclude depreciation incurred with respect to Permitted Capital Expenditures from Operating Costs; (xxiii) any compensation paid to personnel in retail concessions operated by Landlord and any subsidies or concessions to third parties
operating retail concessions at the Building or the Campus, provided that the provisions of this clause (xxiii) shall not be deemed to exclude from Operating Costs such compensation, subsidies or concessions incurred by Landlord with respect
the Cafeteria and the Fitness Center; (xxiv) replacement or contingency reserves; (xxv) Landlord’s general overhead, provided however, that the provisions of this clause (xxiv) shall not be deemed to exclude an equitable
allocation of Management Office Costs, as set forth in Section 5.2(a) above; and (xxvi) any costs incurred with respect to the retail portions of the Building, provided that the provisions of this clause (xxiii) shall not be deemed to
exclude from Operating Costs incurred by Landlord with respect the Cafeteria and the Fitness Center. Notwithstanding anything to the contrary contained herein, the properly passed through cost of any Permitted Capital Expenditures shall be amortized
over the useful life of such capital item. 
 (c) Payment of Operating Costs. Commencing as of the applicable Additional Rent
Commencement Date for the North Premises and for the South Premises and continuing thereafter throughout the remainder of the Term of the Lease, Tenant shall pay to Landlord, as Additional Rent, Tenant’s Share of Operating Costs. Landlord may
make a good faith estimate of Tenant’s Share of Operating Costs for any fiscal year or part thereof during the term, and Tenant shall pay to Landlord, on the Additional Rent Commencement Date and on the first (1st) day of each calendar month
thereafter, an amount equal to Tenant’s Share of Operating Costs for such fiscal year and/or part thereof divided by the number of months therein. Landlord may estimate and re-estimate Tenant’s Share
of Operating Costs and deliver a copy of the estimate or re-estimate to Tenant. Thereafter, the monthly installments of Tenant’s Share of Operating Costs shall be appropriately adjusted in accordance with
the estimations so that, by the end of the fiscal year in question, Tenant shall have paid all of Tenant’s Share of Operating Costs as estimated by Landlord. Any amounts paid based on such an estimate shall be subject to adjustment as herein
provided when actual Operating Costs are available for each fiscal year. As of the Execution Date, the Property’s fiscal year is January 1 – December 31. 

(d) Annual Reconciliation. Landlord shall, within one hundred twenty (120) days after the end of each fiscal year, deliver to
Tenant a reasonably detailed statement of the actual amount of Operating Costs for such fiscal year (“Year End Statement”). Failure of Landlord to provide the Year End Statement within the time prescribed shall not relieve Tenant
from its obligations hereunder; provided, however, Landlord shall be obligated to bill any Operating Costs on or before the date (“Outside Billing Date”) which is two (2) years after the end of the fiscal year in which
the expenditure is made. If the total of such monthly remittances on account of any fiscal year is greater than Tenant’s Share of Operating Costs actually incurred for such fiscal year, then, provided no Event of Default has occurred, Tenant
may credit the difference against the next installment of Additional Rent on account of Operating Costs due hereunder, except that if such difference is determined after the end of the Term, Landlord shall refund such difference to Tenant within
thirty (30) days after such determination to the extent 

  
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that such difference exceeds any amounts then due from Tenant to Landlord. If the total of such remittances is less than Tenant’s Share of Operating Costs actually incurred for such fiscal
year, Tenant shall pay the difference to Landlord, as Additional Rent hereunder, within thirty (30) days of Tenant’s receipt of an invoice therefor. Landlord’s estimate of Operating Costs for the next fiscal year shall be based upon
the Operating Costs actually incurred for the prior fiscal year as reflected in the Year-End Statement plus a reasonable adjustment based upon estimated increases in Operating Costs. The provisions of this
Section 5.2(d) shall survive the expiration or earlier termination of this Lease. 
 (e) Part Years. If the applicable
Additional Rent Commencement Date or the Expiration Date occurs in the middle of a calendar year, Tenant shall be liable for only that portion of the Operating Costs with respect to such calendar year within the Term. 

(f) Gross-Up. If, during any fiscal year, less than 95% of the Building is occupied by tenants
or if Landlord was not supplying all tenants with the services being supplied to Tenant hereunder, actual Operating Costs incurred shall be reasonably extrapolated by Landlord on an
item-by-item basis to the reasonable Operating Costs that would have been incurred if the Building was 95% occupied and such services were being supplied to all tenants,
and such extrapolated Operating Costs shall, for all purposes hereof, be deemed to be the Operating Costs for such fiscal year. This “gross up” treatment shall be applied only with respect to variable Operating Costs arising from services
provided to Common Areas or to space in the Building being occupied by tenants (which services are not provided to vacant space or may be provided only to some tenants) in order to allocate equitably such variable Operating Costs to the tenants
receiving the benefits thereof. 
 (g) Audit Right. Provided there is no Event of Default nor any event which, with the passage of
time and/or the giving of notice would constitute an Event of Default, Tenant may, upon at least thirty (30) days’ prior written notice, inspect or audit Landlord’s records relating to Operating Costs for any periods of time within
the previous fiscal year before the audit or inspection. However, no audit or inspection shall extend to periods of time before the earliest to occur of the North Premises Additional Rent Commencement Date or the South Premises Additional Rent
Commencement Date. If Tenant fails to object to the calculation of Tenant’s Share of Operating Costs on the Year-End Statement within ninety (90) days after such statement has been delivered to
Tenant and/or fails to complete any such audit or inspection within one hundred twenty (120) days after receipt of the Year End Statement, then Tenant shall be deemed to have waived its right to object to the calculation of Tenant’s Share
of Operating Costs for the year in question and the calculation thereof as set forth on such statement shall be final. Tenant’s audit or inspection shall be conducted only at Landlord’s offices or the offices of Landlord’s property
manager during business hours reasonably designated by Landlord. Tenant shall pay the cost of such audit or inspection. Tenant may not conduct an inspection or have an audit performed more than once during any fiscal year. If, after such inspection
or audit has been performed, it is finally determined or mutually agreed that there has been an underpayment by Tenant, then Tenant shall pay to Landlord, as Additional Rent hereunder, any underpayment of any such costs, as the case may be, within
thirty (30) days after receipt of an invoice therefor. In the event the Landlord disagrees in good faith with the results of the audit, Landlord shall notify Tenant within fifteen (15) days of the audit, and Landlord and Tenant shall
mutually select a neutral third party to evaluate the charges for Tenant’s Share of Operating Costs, and the results 

  
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of such third party’s evaluation shall bind Landlord and Tenant and shall be final. Costs charged by any such third party shall be shared equally by Landlord and Tenant. If, after such
inspection or audit has been performed, it is finally determined or mutually agreed that that there has been overpayment by Tenant, then Landlord shall credit such overpayment against the next installment(s) of Base Rent thereafter payable by
Tenant, except that if such overpayment is determined after the termination or expiration of the Term, Landlord shall promptly refund to Tenant the amount of such overpayment less any amounts then due from Tenant to Landlord. Tenant shall maintain
the results of any such audit or inspection confidential and shall not be permitted to use any third party to perform such audit or inspection, other than an independent firm of certified public accountants (A) reasonably acceptable to
Landlord, (B) which is not compensated on a contingency fee basis or in any other manner which is dependent upon the results of such audit or inspection, and (C) which executes Landlord’s standard confidentiality agreement whereby it
shall agree to maintain the results of such audit or inspection confidential. The provisions of this Section 5.2(g) shall survive the expiration or earlier termination of this Lease. 

5.3 Taxes. 
 (a)
“Taxes” shall mean the real estate taxes and other taxes, levies and assessments imposed upon the Unit of the Condominium in which the Building and the Land, are located (the “Unit”), and upon any personal property
of Landlord used in the operation thereof, or on Landlord’s interest therein or such personal property; charges, fees and assessments for transit, housing, police, fire or other services or purported benefits to the Building and the Land
(including without limitation any community preservation assessments); service or user payments in lieu of taxes; and any and all other taxes, levies, betterments, assessments and charges arising from the ownership, leasing, operation, use or
occupancy of the Building and the Land or based upon rentals derived therefrom, which are or shall be imposed by federal, state, county, municipal or other governmental authorities. Taxes shall not include any inheritance, estate, succession, gift,
franchise, rental, income or profit tax, capital stock tax, capital levy or excise, or any income taxes arising out of or related to the ownership and operation of the Unit, provided, however, that any of the same and any other tax, excise, fee,
levy, charge or assessment, however described, that may in the future be levied or assessed as a substitute for or an addition to, in whole or in part, any tax, levy or assessment which would otherwise constitute Taxes, whether or not now customary
or in the contemplation of the parties on the Execution Date of this Lease, shall constitute Taxes, but only to the extent calculated as if the Unit were the only real estate owned by Landlord. “Taxes” shall also include reasonable
expenses (including without limitation legal and consultant fees) of tax abatement or other proceedings contesting assessments or levies. 

Landlord shall allocate Taxes which are incurred with respect to the Common Areas of the Campus on a reasonable basis. From and after
substantial completion of any occupiable improvements constructed as part of a Future Development, if such improvements are not separately assessed, Landlord shall reasonably allocate Taxes between the Building and such improvements and the land
area associated with the same. From and after the creation of the Condominium for the Campus, such allocation shall be effected based upon the Taxes payable by Landlord with respect to the unit in the Condominium in which the Property is located.

  
 PAGE 19 

 (b) “Tax Period” shall be any fiscal/tax period in respect of
which Taxes are due and payable to the appropriate governmental taxing authority (i.e., as mandated by the governmental taxing authority), any portion of which period occurs during the Term of this Lease. 

(c) Payment of Taxes. Commencing as of the applicable Additional Rent Commencement Dates for the North Premises and for the South
Premises and continuing thereafter throughout the remainder of the Term of the Lease, Tenant shall pay to Landlord, as Additional Rent, Tenant’s Share of Taxes. Landlord may make a good faith estimate of the Taxes to be due by Tenant for any
Tax Period or part thereof during the Term, and Tenant shall pay to Landlord, on the Rent Commencement Date and on the first (1st) day of each calendar month thereafter, an amount equal to Tenant’s Share of Taxes for such Tax Period or part
thereof divided by the number of months therein. Landlord may estimate and re-estimate Tenant’s Share of Taxes and deliver a copy of the estimate or re-estimate to
Tenant. Thereafter, the monthly installments of Tenant’s Share of Taxes shall be appropriately adjusted in accordance with the estimations so that, by the end of the Tax Period in question, Tenant shall have paid all of Tenant’s Share of
Taxes as estimated by Landlord. Any amounts paid based on such an estimate shall be subject to adjustment as herein provided when actual Taxes are available for each Tax Period. If the total of such monthly remittances is greater than Tenant’s
Share of Taxes actually due for such Tax Period, then, provided no Event of Default has occurred, Tenant may credit the difference against the next installment of Additional Rent on account of Taxes due hereunder, except that if such difference is
determined after the end of the Term, Landlord shall refund such difference to Tenant within thirty (30) days after such determination to the extent that such difference exceeds any amounts then due from Tenant to Landlord. If the total of such
remittances is less than Tenant’s Share of Taxes actually due for such Tax Period, Tenant shall pay the difference to Landlord, as Additional Rent hereunder, within thirty (30) days of Tenant’s receipt of an invoice therefor.
Landlord’s estimate for the next Tax Period shall be based upon actual Taxes for the prior Tax Period plus a reasonable adjustment based upon estimated increases in Taxes. The provisions of this Section 5.3(c) shall survive the expiration
or earlier termination of this Lease. 
 (d) Effect of Abatements. Appropriate credit against Taxes shall be given for any refund
obtained by reason of a reduction in any Taxes by the assessors or the administrative, judicial or other governmental agency responsible therefor after deduction of Landlord’s expenditures for reasonable legal fees and for other reasonable
expenses incurred in obtaining the Tax refund. 
 (e) Part Years. If the applicable Additional Rent Commencement Date or the
Expiration Date occurs in the middle of a Tax Period, Tenant shall be liable for only that portion of the Taxes, as the case may be, with respect to such Tax Period within the Term. 

5.4 Late Payments. 

(a) Any payment of Rent due hereunder not paid when due shall bear interest for each month or fraction thereof from the due date until paid in
full at the annual rate of eighteen percent (18%), or at any applicable lesser maximum legally permissible rate for debts of this nature (the “Default Rate”). 

  
 PAGE 20 

 (b) Additionally, if Tenant fails to make any payment within five (5) days after the
due date therefor, Landlord may charge Tenant a fee, which shall constitute liquidated damages, equal to three (3%) of any such late payment; provided, however, Landlord shall waive the late fee once in any twelve-(12)-month period in the event
Tenant shall pay such late payment within five (5) days following Landlord’s written notice to Tenant of the occurrence of such late payment. 

(c) For each Tenant payment check to Landlord that is returned by a bank for any reason, Tenant shall pay a returned check charge equal to the
amount as shall be customarily charged by Landlord’s bank at the time. 
 (d) Money paid by Tenant to Landlord shall be applied to
Tenant’s account in the following order: first, to any unpaid Additional Rent, including without limitation late charges, returned check charges, legal fees and/or court costs chargeable to Tenant hereunder; and then to unpaid Base Rent. 

(e) The parties agree that the late charge referenced in Section 5.4(b) represents a fair and reasonable estimate of the costs that
Landlord will incur by reason of any late payment by Tenant, and the payment of late charges and interest are distinct and separate in that the payment of interest is to compensate Landlord for the use of Landlord’s money by Tenant, while the
payment of late charges is to compensate Landlord for Landlord’s processing, administrative and other costs incurred by Landlord as a result of Tenant’s delinquent payments. Acceptance of a late charge or interest shall not constitute a
waiver of Tenant’s default with respect to the overdue amount or prevent Landlord from exercising any of the other rights and remedies available to Landlord under this Lease or at law or in equity now or hereafter in effect. 

(f) If Tenant during any six (6) month period shall be more than five (5) days delinquent in the payment of any installment of Rent
on three (3) or more occasions, then, notwithstanding anything herein to the contrary, Landlord may, by written notice to Tenant, elect to require Tenant to pay all Base Rent and Additional Rent on account of Operating Costs and Taxes quarterly
in advance. Such right shall be in addition to and not in lieu of any other right or remedy available to Landlord hereunder or at law on account of Tenant’s default hereunder. 

5.5 No Offset; Independent Covenants; Waiver. Rent shall be paid without notice or demand, and without setoff, counterclaim, defense,
abatement, suspension, deferment, reduction or deduction, except as expressly provided herein. TENANT WAIVES ALL RIGHTS (I) TO ANY ABATEMENT, SUSPENSION, DEFERMENT, REDUCTION OR DEDUCTION OF OR FROM RENT, AND (II) TO QUIT, TERMINATE OR
SURRENDER THIS LEASE OR THE PREMISES OR ANY PART THEREOF, EXCEPT AS EXPRESSLY PROVIDED HEREIN. TENANT HEREBY ACKNOWLEDGES AND AGREES THAT THE OBLIGATIONS OF TENANT HEREUNDER SHALL BE SEPARATE AND INDEPENDENT COVENANTS AND AGREEMENTS, THAT RENT SHALL
CONTINUE TO BE PAYABLE IN ALL EVENTS AND THAT THE OBLIGATIONS OF TENANT HEREUNDER SHALL CONTINUE UNAFFECTED, UNLESS THE REQUIREMENT TO PAY OR PERFORM THE SAME SHALL HAVE BEEN TERMINATED PURSUANT TO AN EXPRESS PROVISION OF THIS LEASE. LANDLORD AND
TENANT EACH ACKNOWLEDGES AND AGREES THAT THE 

  
 PAGE 21 

 
INDEPENDENT NATURE OF THE OBLIGATIONS OF TENANT HEREUNDER REPRESENTS FAIR, REASONABLE, AND ACCEPTED COMMERCIAL PRACTICE WITH RESPECT TO THE TYPE OF PROPERTY SUBJECT TO THIS LEASE, AND THAT THIS
AGREEMENT IS THE PRODUCT OF FREE AND INFORMED NEGOTIATION DURING WHICH BOTH LANDLORD AND TENANT WERE REPRESENTED BY COUNSEL SKILLED IN NEGOTIATING AND DRAFTING COMMERCIAL LEASES IN MASSACHUSETTS, AND THAT THE ACKNOWLEDGEMENTS AND AGREEMENTS
CONTAINED HEREIN ARE MADE WITH FULL KNOWLEDGE OF THE HOLDING IN WESSON V. LEONE ENTERPRISES, INC., 437 MASS. 708 (2002). SUCH ACKNOWLEDGEMENTS, AGREEMENTS AND WAIVERS BY TENANT ARE A MATERIAL INDUCEMENT TO LANDLORD ENTERING INTO THIS LEASE.

 5.6 Survival. Any obligations under this Section 5 which shall not have been paid at the expiration or earlier
termination of the Term shall survive such expiration or earlier termination and shall be paid when and as the amount of same shall be determined and be due. 
  

	6.	 INTENTIONALLY OMITTED 

 

	7.	 CASH SECURITY DEPOSIT/LETTER OF CREDIT 

7.1 Amount. Tenant shall, on or before the date five (5) business days after Tenant satisfies the Tenant Financing Contingency, as
defined in Section III of Exhibit 11 of this Lease, deliver to Landlord either (at Tenant’s election): (i) cash in the initial amount of $2,057,658.75 (the “Cash Security Deposit”), which shall be held by Landlord in
accordance with Section 7.4 below, or (ii) an irrevocable letter of credit (the “Letter of Credit”) which shall be held by Landlord in accordance with Section 7.4 below and shall (a) be in the initial amount of
$2,057,658.75; (b) be issued on the form attached hereto as Exhibit 6 or other form reasonably approved by Landlord; (c) name Landlord as its beneficiary; (d) be drawn on an FDIC insured financial institution reasonably satisfactory
to Landlord (“Approved Issuer”) that both (x) has an office in the greater Boston metropolitan area that will accept or allow for facsimile presentment for the payment of the Letter of Credit, and (y) satisfies both the
Minimum Rating Agency Threshold and the Minimum Capital Threshold (as those terms are defined below). The “Minimum Rating Agency Threshold” shall mean that the issuing bank has outstanding unsecured, uninsured and unguaranteed
senior long-term indebtedness that is then rated (without regard to qualification of such rating by symbols such as “+” or “-” or numerical notation) “Baa” or better by Moody’s Investors
Service, Inc. and/or “BBB” or better by Standard & Poor’s Rating Services, or a comparable rating by a comparable national rating agency designated by Landlord in its discretion. The “Minimum Capital
Threshold” shall mean that the issuing bank has combined capital, surplus and undivided profits of not less than $10,000,000,000. Notwithstanding the foregoing, Landlord hereby agrees that, as of the Execution Date: (i) Square One and
Pacific Western are each Approved Issuers, and (ii) each of Square One and Pacific Western will remain as Approved Issuers so long as it maintains combined capital, surplus and undivided profits of either Square One or Pacific of at least
$2,000,000,000. The Letter of Credit (and any renewals or replacements thereof) shall be for a term of not less than one (1) year. If the issuer of the Letter of Credit gives notice of its election not to renew such Letter of Credit for any
additional period, Tenant shall be required to deliver a 

  
 PAGE 22 

 
substitute Letter of Credit satisfying the conditions of this Article 7 at least sixty (60) days prior to the expiration of the term of such Letter of Credit. If the issuer of the Letter of
Credit ceases to satisfy the applicable requirements which are necessary to maintain its status as an Approved Issuer, Tenant shall be required, not later than ten (10) business days after Landlord notifies Tenant of such failure, to deliver to
Landlord a substitute letter of credit from an Approved Issuer. Tenant agrees that it shall, from time to time, as necessary, whether as a result of a draw on the Letter of Credit by Landlord pursuant to the terms hereof or as a result of the
expiration of the Letter of Credit then in effect, renew or replace the original and any subsequent Letter of Credit so that a Letter of Credit, in the amount required hereunder, is in effect until a date which is at least sixty (60) days after
the Expiration Date. If Tenant fails to furnish such renewal or replacement at least sixty (60) days prior to the stated expiration date of the Letter of Credit then held by Landlord, Landlord may draw upon such Letter of Credit and hold the
proceeds thereof (and such proceeds need not be segregated) as a Security Deposit pursuant to the terms of this Article 7. At any time that Landlord is holding a Cash Security Deposit, Tenant, at its election, may exchange a Letter of Credit
satisfying the requirements of this Article 7 for the Cash Security Deposit then being held by Landlord. Any renewal or replacement of the original or any subsequent Letter of Credit shall meet the requirements for the original Letter of Credit as
set forth above, except that such replacement or renewal shall be issued by an Approved Issuer. 
 7.2 Application of Proceeds of Letter
of Credit. Upon an Event of Default, or if any proceeding shall be instituted by or against Tenant pursuant to any of the provisions of any Act of Congress or State law relating to bankruptcy, reorganizations, arrangements, compositions or other
relief from creditors (and, in the case of any proceeding instituted against it, if Tenant shall fail to have such proceedings dismissed within thirty (30) days) or if Tenant is adjudged bankrupt or insolvent as a result of any such proceeding,
Landlord at its sole option may draw down all or a part of the Letter of Credit. The balance of any Letter of Credit cash proceeds shall be held in accordance with Section 7.4 below as a Cash Security Deposit. Should the entire Letter of
Credit, or any portion thereof, be drawn down by Landlord, Tenant shall, upon the written demand of Landlord, deliver a replacement Letter of Credit in the amount drawn, and Tenant’s failure to do so within ten (10) days after receipt of
such written demand shall constitute an additional Event of Default hereunder. The application of all or any part of the cash proceeds of the Letter of Credit to any obligation or default of Tenant under this Lease shall not deprive Landlord of any
other rights or remedies Landlord may have nor shall such application by Landlord constitute a waiver by Landlord. 
 7.3 Transfer of
Letter of Credit. In the event that Landlord transfers its interest in the Premises, Tenant shall upon notice from and at no cost to Landlord, deliver to Landlord an amendment to the Letter of Credit or a replacement Letter of Credit naming
Landlord’s successor as the beneficiary thereof. If Tenant fails to deliver such amendment or replacement within ten (10) business days after written notice from Landlord, Landlord shall have the right to draw down the entire amount of the
Letter of Credit and hold the proceeds thereof in accordance with Section 7.4 below. 
 7.4 Cash Proceeds of Letter of Credit.
Landlord shall hold the Cash Security Deposit, the Letter of Credit, the balance of proceeds remaining after a draw on Cash Security Deposit and/or the Letter of Credit, as the case may be (each sometimes hereinafter referred to collectively as the
“Security Deposit”) as security for Tenant’s performance of all its Lease 

  
 PAGE 23 

 
obligations. After an Event of Default, Landlord may apply the Security Deposit, or any part thereof, to Landlord’s damages without prejudice to any other Landlord remedy. Landlord has no
obligation to pay interest on the Security Deposit and may co-mingle the Security Deposit with Landlord’s funds. If Landlord conveys its interest under this Lease, the Security Deposit, or any part not
applied previously, may be turned over to the grantee in which case Tenant shall look solely to the grantee for the proper application and return of the Security Deposit. 

7.5 Return of Security Deposit or Letter of Credit. Should Tenant comply with all of such terms, covenants and conditions and promptly
pay all sums payable by Tenant to Landlord hereunder, the Security Deposit shall (less any portion thereof which may have been utilized by Landlord to cure any default or applied to any actual damage suffered by Landlord) be returned to Tenant
within forty-five (45) days after the latest to occur of: (i) the end of the Term, (ii) the delivery by Tenant to Landlord of the Premises free and clear of all parties claiming under Tenant and in compliance with Section 21 of
the Lease, and (iii) the delivery to Landlord of an acceptable Surrender Report, as defined in Section 21 of the Lease, unless an Event of Default (or a default that with notice and the passage of time would constitute an Event of Default)
exists at the end of the Term, in which event, the forty-five-(45)-day period shall commence on the date that Tenant cures such Event of Default or default. 

7.6 Reduction of the Cash Security Deposit and/or Letter of Credit.

(a) On the conditions (the “Reduction Conditions”) that as of the applicable Effective Reduction Date, as hereinafter
defined: (x) Tenant is then in full compliance with its obligations under the Lease, and (y) there has been no Event of Default during the twelve-month period immediately preceding such Effective Reduction Date, as it may be delayed, as
hereinafter set forth (“Prior Default Condition”), then the amount of the Cash Security Deposit/Letter of Credit may be reduced in accordance with the below-listed schedule: 

 

					
	 Effective Reduction Date
	  	
New Reduced Security Deposit Amount
	 
	 Second (2nd) anniversary of North

Premises Base Rent Commencement
 Date:
	  	 	$1,829,020.00	 
	 Fourth (4th) anniversary of North

Premises Base Rent Commencement
 Date:
	  	 	$1,600,391.25	 
	 Sixth (6th) anniversary of North

Premises Base Rent Commencement
 Date:
	  	 	$1,371,762.50	 

 (b) The reduction in the Security Deposit shall be accomplished as follows: (a) for a Cash Security
Deposit, Tenant shall request such reduction in a written notice to Landlord (the “Reduction Notice”), and if Landlord, in good faith, determines that the Reduction Conditions have been met, Landlord shall, within ten
(10) business days after Landlord’s receipt of such Reduction Notice, refund to Tenant a portion of the Cash Security Deposit which Landlord is then holding so that Landlord will be holding the reduced amount, as 

  
 PAGE 24 

 
set forth above, and (b) for a Security Deposit in the form of a Letter of Credit, Tenant shall give a Reduction Notice to Landlord, and if Landlord, in good faith, determines that the
Reduction Conditions have been met, Landlord shall, within five (5) business days of its receipt of such Reduction Notice, so notify Tenant, whereupon Tenant shall either deliver to Landlord either: (i) a Substitute Letter of Credit in the
applicable reduced amount, in form satisfying the requirements of this Section 7, or (ii) an amendment to the existing Letter of Credit, in form and substance reasonably acceptable to Landlord, reducing the amount of the existing Letter of
Credit to the applicable reduced amount. If Tenant delivers to Landlord a Substitute Letter of Credit satisfying the foregoing requirements, as aforesaid, then Landlord shall exchange the existing Letter of Credit which Landlord is then holding for
such Substitute Letter of Credit within ten (10) days after Landlord receives such Substitute Letter of Credit to Landlord. If Landlord declines to reduce the Security Deposit based upon the fact that any of the Reduction Conditions have not
been satisfied, but Tenant subsequently satisfies the Reduction Conditions, then Tenant may submit a new Reduction Notice to Landlord for the reduction in the Security Deposit in accordance with the provisions of this Section 7.6. In such
event, the Prior Default Condition shall be determined based on the twelve-(12)-month period immediately preceding the delayed Effective Reduction Date. 

(c) In no event shall the Cash Security Deposit/Letter of Credit ever be less than $1,371,762.50. The Security Deposit, as it may be reduced
in accordance with the foregoing, shall continue to be held by Landlord throughout the Term of the Lease. 
  

	8.	 INTENTIONALLY OMITTED 

 

	9.	 UTILITIES, LANDLORD’S SERVICES 

9.1 Electricity.
 (a)
Landlord shall contract with the utility provider for electric service to the Property, including the Premises. Commencing on the Term Commencement Date, Tenant shall pay all charges for electricity furnished to the Premises and any equipment
exclusively serving the Premises, as Additional Rent, based on the submeter(s), either currently installed or to be installed in the North Premises by Landlord as part of Landlord’s Work and in the South Premises by Tenant as part of
Tenant’s Work; provided, however, the cost of such submetering shall be at Landlord’s sole cost and expense and shall not be deducted from Landlord’s Contribution. At Tenant’s request, Landlord shall provide Tenant with
reasonable back-up documentation regarding the total charges and the method of allocating the charges to Tenant. Tenant shall, at Tenant’s sole cost and expense, maintain and keep in good order, condition
and repair the metering equipment used to measure electricity furnished to the Premises and any equipment exclusively serving the same. 

(b) Commencing as of the Term Commencement Date for each portion of the Premises, Tenant pay to Landlord estimated payments (i.e., based upon
Landlord’s reasonable estimate) on account of Tenant’s obligation to reimburse Landlord for electricity consumed in the Premises. Such payments shall be made at the same time and in the same manner that Tenant pays Annual Base Rent to
Landlord. Periodically after the Term Commencement Date, Landlord shall determine the actual cost of electricity consumed by Tenant in the Premises (i.e., by reading 

  
 PAGE 25 

 
Tenant’s sub-meter and by applying an electric rate which shall not exceed the retail rate which would have been payable by Tenant had Tenant obtained
electric services directly from the utility company providing electric current to Landlord). If the total of Tenant’s estimated monthly payments on account of such period is less than the actual cost of electricity consumed in the Premises
during such period, Tenant shall pay the difference to Landlord within thirty (30) days of receipt of Landlord’s written demand. If the total of Tenant’s estimated monthly payments on account of such period is greater than the actual
cost of electricity consumed in the Premises during such period, Tenant may credit the difference against its next installment of rental or other charges due hereunder. After each adjustment, as set forth above, the amount of estimated monthly
payments on account of Tenant’s obligation to reimburse Landlord for electricity in the Premises shall be adjusted based upon the actual cost of electricity consumed during the immediately preceding period. 

9.2 Water. Landlord shall contract with the utility provider for water service to the Property, including the Premises. Except as
otherwise provided below, the cost of providing water service to the Premises and all other portions of the Building (including, without limitation, the premises of other tenants or occupants of the Building) shall be included in Operating Costs.
Notwithstanding the foregoing, if Landlord determines that Tenant is using water in excess of its proportionate share (by floor area) of the total water usage in the Building, Landlord may elect, at Tenant’s expense, to furnish and install in a
location in or near the Premises metering equipment to measure water furnished to the Premises and any equipment exclusively serving the same. In such event, Tenant shall, within thirty (30) days after Landlord’s written demand therefor
from time to time, pay to Landlord, as Additional Rent, the full amount of any water service charges attributable to such meter. 
 9.3
Gas. Landlord shall contract with the utility provider for gas service to the Property, including the Premises. The cost of gas used to serve base building plumbing, mechanical and electrical systems shall be included in the costs reimbursed by
Tenant pursuant to Section 9.6 below. If Tenant requires gas service for the operation of Tenant’s laboratory equipment in the Premises, Tenant shall pay all charges for gas furnished to the Premises and/or any equipment exclusively
serving the Premises as Additional Rent, based, at Landlord’s election, (i) on Landlord’s reasonable estimate of such gas usage or (ii) on metering or submetering equipment installed by Landlord at Tenant’s expense. 

9.4 Other Utilities. Subject to Landlord’s reasonable rules and regulations governing the same, Tenant shall obtain and pay, as
and when due, for all other utilities and services consumed in and/or furnished to the Premises, together with all taxes, penalties, surcharges and maintenance charges pertaining thereto. 

9.5 Interruption or Curtailment of Utilities. When necessary by reason of accident or emergency, or for repairs, alterations,
replacements or improvements which in the reasonable judgment of Landlord are desirable or necessary to be made, Landlord reserves the right, upon as much prior notice to Tenant as is practicable under the circumstances and no less than twenty-four
(24) hours’ notice except in the event of an emergency, to interrupt, curtail, or stop (i) the furnishing of hot and/or cold water, and (ii) the operation of the plumbing and electric systems. Landlord shall exercise reasonable
diligence to eliminate the cause of any such interruption, curtailment, stoppage or suspension, but, except as set forth in Section 10.7, there shall be no 

  
 PAGE 26 

 
diminution or abatement of Rent or other compensation due from Landlord to Tenant hereunder, nor shall this Lease be affected or any of Tenant’s obligations hereunder reduced, and Landlord
shall have no responsibility or liability for any such interruption, curtailment, stoppage, or suspension of services or systems. 
 9.6
Landlord’s Services. Subject to reimbursement pursuant to Section 5.2 above, Landlord shall provide the services described in Exhibit 7 attached hereto and made a part hereof (“Landlord’s Services”). Except
for the cost of providing and maintaining supplemental HVAC equipment (which shall be Tenant’s responsibility), to the extent allowable pursuant to Section 5.2, all costs incurred in connection with the provision of Landlord’s
Services shall be included in Operating Costs. Landlord shall allocate to the Premises a portion of the total amount of such costs incurred with respect to the Building based upon the cubic footage of heated, chilled, and fresh air distributed in
the Premises as indicated by the energy management system serving the Building as a percentage of the aggregate cubic footage of heated, chilled, and fresh air distributed in the entire Building for the applicable period. Tenant shall pay such costs
monthly, together with monthly installments of Base Rent, on an estimated basis in amounts from time to time reasonably determined by Landlord. After the close of each fiscal year, Landlord shall determine the actual amount of such costs for such
year and deliver to Tenant a reasonably detailed statement thereof, together with a statement of the amounts paid by Tenant on an estimated basis toward such costs as aforesaid. If such statement indicates that the estimated amounts paid by Tenant
are less than Tenant’s allocable share of the actual amount of such costs for such fiscal year, then Tenant shall pay the amount of such shortfall to Landlord within thirty (30) days after delivery of such statement. If such statement
indicates that Tenant’s estimated payments for such year exceed the actual amount of such costs for such year, then Landlord shall credit the excess against the next due installment(s) of Additional Rent payable under this Section 9.6.

  

	10.	 MAINTENANCE AND REPAIRS 

10.1 Maintenance and Repairs by Tenant. Tenant shall keep neat and clean and free of insects, rodents, vermin and other pests and in
good repair, order and condition (reasonable wear and tear and damage by Casualty excepted): the Premises, including without limitation the entire interior of the Premises, all electronic, phone and data cabling and related equipment (other than
building service equipment) that is installed by or for the exclusive benefit of the Tenant (whether located in the Premises or other portions of the Building), all fixtures, equipment and specialty lighting therein, any supplemental HVAC and
humidification equipment exclusively serving the Premises, electrical equipment wiring, doors, non-structural walls, windows and floor coverings, and all laboratory specific systems and equipment that
exclusively serve the Premises, including, without limitation, equipment critical to laboratory operations. Without limiting the foregoing, Tenant agrees that it shall maintain any equipment which is the responsibility for Tenant to maintain as set
forth on Exhibit 4-2 in the same repair, order, and condition (reasonable wear and tear and damage by Casualty excepted) in which such equipment is in as of the Term Commencement Date of the portion of
the Premises in which such equipment is located. 

  
 PAGE 27 

 10.2 Maintenance and Repairs by Landlord. Except as otherwise provided in
Section 15, and subject to Tenant’s obligations in Section 10.1 above, Landlord shall maintain and keep in good working order the Building foundation, the roof, Building structure, the common mechanical systems serving the Building,
the structural floor slabs and columns in good repair, order and condition. In addition, Landlord shall operate and maintain the Common Areas in substantially the same manner as comparable combination office and laboratory facilities in the vicinity
of the Premises. All costs incurred by Landlord under this Section 10.2 shall be included in Operating Costs, subject to, and in accordance with Section 5.2. 

10.3 Accidents to Sanitary and Other Systems. Tenant shall give to Landlord prompt notice of any fire or accident in the Premises or in
the Building and of any damage to, or defective condition in, any part or appurtenance of the Building including, without limitation, sanitary, electrical, ventilation, heating and air conditioning or other systems located in, or passing through,
the Premises. Except as otherwise provided in Section 15, and subject to Tenant’s obligations in Section 10.1 above, such damage or defective condition shall be remedied by Landlord with reasonable diligence, but, subject to
Section 14.5 below, if such damage or defective condition was caused by any of the Tenant Parties, the cost to remedy the same shall be paid by Tenant. 

10.4 Floor Load—Heavy Equipment. Tenant shall not place a load upon any floor of the Premises exceeding the floor load per square
foot of area which such floor was designed to carry and which is allowed by Legal Requirements. The floor load for the first floor portions of the Prime Premises is 125 lbs. per square foot, and the floor load for the Expansion Premises is 100 lbs.
per square foot. Landlord reserves the right to prescribe the weight and position of all safes, heavy machinery, heavy equipment, freight, bulky matter or fixtures (collectively, “Heavy Equipment”), which shall be placed so as to
distribute the weight. Heavy Equipment shall be placed and maintained by Tenant at Tenant’s expense in settings sufficient in Landlord’s reasonable judgment to absorb and prevent vibration, noise and annoyance. Tenant shall not move any
Heavy Equipment into or out of the Building without giving Landlord prior written notice thereof and observing all of Landlord’s Rules and Regulations with respect to the same. If such Heavy Equipment requires special handling, Tenant agrees to
employ only persons holding a Master Rigger’s License to do said work, and that all work in connection therewith shall comply with Legal Requirements. Any such moving shall be at the sole risk and hazard of Tenant and Tenant will defend,
indemnify and save Landlord and Landlord’s agents (including without limitation its property manager), contractors and employees (collectively with Landlord, the “Landlord Parties”) harmless from and against any and all claims,
damages, losses, penalties, costs, expenses and fees (including without limitation reasonable legal fees) (collectively, “Claims”) resulting directly or indirectly from such moving, except, subject to Section 14.5 of the Lease,
to the extent caused by the negligence or willful misconduct of any Landlord Parties. Proper placement of all Heavy Equipment in the Premises shall be Tenant’s responsibility. 

10.5 Premises Cleaning. Tenant shall be responsible, at its sole cost and expense, for janitorial and removing trash from the Premises
to the common dumpster designated by Landlord and for providing biohazard disposal services for the Premises, including the laboratory areas thereof. Such services shall be performed by licensed (where required by law or governmental regulation),
insured and qualified contractors approved in advance, in writing, by Landlord (which approval shall not be unreasonably withheld, delayed or conditioned) and on a sufficient basis to ensure that the Premises are at all times kept neat and clean.
Landlord shall provide a dumpster and/or compactor at the Building loading dock for Tenant’s disposal of non-hazardous and non-controlled substances. 

  
 PAGE 28 

 10.6 Pest Control. Tenant, at Tenant’s sole cost and expense, shall cause the
Premises to be exterminated on a monthly basis to Landlord’s reasonable satisfaction and shall cause all portions of the Premises used for the storage, preparation, service or consumption of food or beverages to be cleaned daily in a manner
reasonably satisfactory to Landlord, and to be treated against infestation by insects, rodents and other vermin and pests whenever there is evidence of any infestation. Tenant shall not permit any person to enter the Premises for the purpose of
providing such extermination services, unless such persons have been approved by Landlord. If requested by Landlord, Tenant shall, at Tenant’s sole cost and expense, store any refuse generated in the Premises by the consumption of food or
beverages in a cold box or similar facility. 
 10.7 Service Interruptions. 

(a) Abatement of Rent. In the event that: (i) there shall be an interruption, curtailment or suspension of any service or failure
to perform any obligation required to be provided or performed by Landlord pursuant to Sections 9 and/or 10 (and no reasonably equivalent alternative service or supply is provided by Landlord) that shall materially interfere with Tenant’s use
and enjoyment of the Premises, or any portion thereof (any such event, a “Service Interruption”), and (ii) such Service Interruption shall continue for five (5) consecutive business days following receipt by
Landlord of written notice (the “Service Interruption Notice”) from Tenant describing such Service Interruption (“Abatement Service Interruption Cure Period”), and (iii) such Service Interruption shall
not have been caused by an act or omission of Tenant or Tenant’s agents, employees, contractors or invitees (an event that satisfies the foregoing conditions (i)-(iii) being referred to hereinafter as a “Material Service
Interruption”) then, Tenant, subject to the next following sentence, shall be entitled to an equitable abatement of Base Rent, Operating Costs and Taxes based on the nature and duration of the Material Service Interruption and the
area of the Premises affected, for any and all days following the Material Service Interruption Cure Period that both (x) the Material Service Interruption is continuing and (y) Tenant does not use such affected areas of the
Premises for any of the Permitted Uses. Any efforts by Tenant to respond or react to any Material Service Interruption, including, without limitation, any activities by Tenant to remove its personal property from the affected areas of the Premises,
shall not constitute a use that precludes abatement pursuant to this Section 10.7(a). The Abatement Service Interruption Cure Period shall be extended by reason of any delays in Landlord’s ability to cure the Service Interruption in
question caused by Landlord’s Force Majeure, provided however, that in no event shall the Abatement Service Interruption Cure Period with respect to any Service Interruption be longer than ten (10) consecutive business days after Landlord
receives the applicable Service Interruption Notice. 
 (b) Tenant’s Termination Right. In the event that: (i) a Service
Interruption occurs, and (ii) such Service Interruption continues for a period of ninety (90) consecutive days after Landlord receives a Service Interruption Notice with respect to such Service Interruption (“Termination Service
Interruption Cure Period”), and (iii) such Service Interruption shall not have been caused by an act or omission of Tenant or Tenant’s agents, employees, or 

  
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contractors, and (iv) for so long as Tenant ceases to use the affected portion of the Premises during such Service Interruption, then Tenant shall have the right to terminate this Lease by
giving a written termination notice to Landlord after the expiration of the Termination Service Interruption Cure Period. If such Service Interruption is cured within ten (10) days (“Post-Termination Notice Cure Period”) after
Landlord receives such termination notice, then Tenant shall have no right to terminate this Lease based upon such Service Interruption and Tenant’s termination notice shall be of no force or effect. The Termination Service Interruption Cure
Period and the Post-Termination Notice Cure Period shall each be extended by reason of any delays in Landlord’s ability to cure the Service Interruption in question caused by Landlord’s Force Majeure, provided however, that in no event
shall the aggregate extension of the Termination Service Interruption Cure Period and the Post-Termination Notice Cure Period by reason of Landlord’s Force Majeure exceed sixty (60) days. 

(c) The provisions of this Section 10.7 shall not apply in the event of a Service Interruption caused by Casualty or Taking (see
Section 15 below). 
 (d) The provisions of this Section 10.7 set forth Tenant’s sole rights and remedies, both in law and in
equity in the event of any Service Interruption. 
  

	11.	 ALTERATIONS AND IMPROVEMENTS BY TENANT 

11.1 Procedures for Performing Alterations. 

(a) Tenant shall not make any alterations, decorations, installations, removals, additions or improvements (collectively with Tenant’s
Work, “Alterations”) in or to the Premises without Landlord’s prior written approval of the contractor(s), written plans and specifications and a time schedule therefor. Landlord reserves the right to require that Tenant use
Landlord’s preferred vendor(s) for any Alterations that involve roof penetrations, alarm tie-ins, sprinklers, fire alarm and other life safety equipment. Tenant shall not make any amendments or additions
to plans and specifications approved by Landlord without Landlord’s prior written consent. Landlord’s approval of non-structural Alterations shall not be unreasonably withheld, conditioned or
delayed. Notwithstanding the foregoing, Landlord may withhold its consent in its sole discretion (i) to any Alteration to or affecting the fixed lab benches, fume hoods, roof and/or building systems, (ii) with respect to matters of
aesthetics relating to Alterations to or affecting the exterior of the Building, and (iii) to any Alteration affecting the Building structure. Tenant shall be responsible for all elements of the design of Tenant’s plans (including, without
limitation, compliance with Legal Requirements, functionality of design, the structural integrity of the design, the configuration of the Premises and the placement of Tenant’s furniture, appliances and equipment), and Landlord’s approval
of Tenant’s plans shall in no event relieve Tenant of the responsibility for such design. Landlord shall have no liability or responsibility for any claim, injury or damage alleged to have been caused by the particular materials (whether
building standard or non-building standard), appliances or equipment selected by Tenant in connection with any work performed by or on behalf of Tenant. Except as otherwise expressly set forth herein, all
Alterations shall be done at Tenant’s sole cost and expense and at such times and in such manner as Landlord may from time to time reasonably designate. If Tenant shall make any Alterations, then Landlord may elect to require Tenant at the
expiration or sooner termination of the Term to restore the Premises to substantially the same condition as existed immediately prior to the Alterations. Tenant shall provide Landlord with reproducible record drawings (in CAD format) of all
Alterations within sixty (60) days after completion thereof. 

  
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 (b) Alteration Approval Documentation. In seeking Landlord’s approval, Tenant
shall provide Landlord, at least fourteen (14) days in advance of any proposed construction, with plans, specifications, bid proposals, certified stamped engineering drawings and calculations by Tenant’s engineer of record or architect of
record, (including connections to the Building’s structural system, the Building’s mechanical, electrical and plumbing systems, modifications to the Building’s envelope, non-structural
penetrations in slabs or walls, and modifications or tie-ins to life safety systems), work contracts, requests for laydown areas and such other information concerning the nature and cost of the Alteration as
Landlord may reasonably request (collectively “Alteration Approval Documentation”). Notwithstanding the foregoing, with respect to any Minor Electrical Connection, as hereinafter defined: (i) the Alteration
Approval Documentation shall consist of only such of the foregoing documentation as Landlord, in its reasonable judgment, deems customary and necessary for such an Alteration, and (ii) Tenant shall be required to deliver the applicable
Alteration Approval Documentation to Landlord at least five (5) business days in advance of the performance of such Minor Election Connection. A “Minor Electrical Connection” shall consist of the connection of Tenant’s
electrical equipment to the base building electrical system which, in Landlord’s reasonable judgment, will not affect Building operations or the operations of other tenants or occupants of the Building. For avoidance of doubt, Tenant’s
plugging of equipment into existing electrical outlets shall not be deemed to be either an Alteration or a Minor Electrical Connection. 

(c) Alterations Permitted without Landlord’s Consent. Notwithstanding anything to the contrary herein contained, Tenant shall have
the right without obtaining the prior consent of Landlord, but upon prior notice to Landlord as provided below, to make Alterations to the Premises where: (i) the same are within the interior of the Premises, and do not affect the exterior of
the Building and do not affect any of the Building’s systems or the ceiling of the Premises; (ii) the same do not affect the roof or any structural element of the Building, or the fire protection systems of the Building; (iii) the
cost of any individual Alteration shall not exceed $100,000.00 in cost; (iv) Tenant shall comply with the provisions of this Lease, and if such work increases the cost of insurance or taxes, Tenant shall pay for any such increase in cost; and
(v) Tenant gives Landlord at least five (5) business days’ prior notice describing such work in reasonable detail, accompanied by copies of plans and specifications therefor (to the extent plans and specifications are typically
prepared in accordance with such work (the “Permitted Alterations”). 
 (d) After-Hours. Landlord and Tenant
recognize that to the extent Tenant elects to perform some or all of the Alterations during times other than normal construction hours (i.e., Monday-Friday, 7:00 a.m. to 3:00 p.m., excluding holidays), Landlord may need to make arrangements to have
supervisory personnel on site. Accordingly, Landlord and Tenant agree as follows: Tenant shall give Landlord at least two (2) business days’ prior written notice of any time outside of normal construction hours when Tenant intends to
perform any Alterations (the “After-Hours Work”). Tenant shall reimburse Landlord, within ten (10) days after demand therefor, for the cost of Landlord’s supervisory personnel overseeing the After-Hours Work. In addition,
if construction during normal construction hours unreasonably disturbs other tenants of the Building, in Landlord’s sole discretion, Landlord may require Tenant to stop the performance of Alterations during normal construction hours and to
perform the same after hours, subject to the foregoing requirement to pay for the cost of Landlord’s supervisory personnel. 

  
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 11.2 Harmonious Relations. Tenant agrees that it will not, either directly or
indirectly, use any contractors and/or materials if their use will create any difficulty, whether in the nature of a labor dispute or otherwise, with other contractors and/or labor engaged by Tenant or Landlord or others in the construction,
maintenance and/or operation of the Building, the Property or any part thereof. In the event of any such difficulty, upon Landlord’s request, Tenant shall cause all contractors, mechanics or laborers causing such difficulty to leave the
Property immediately. 
 11.3 Liens. No Alterations shall be undertaken by Tenant until: (i) Tenant has made provision for
written waiver of liens from all contractors for such Alteration; and (ii) with respect to any Alteration, the cost of which exceeds $500,000: (x) Tenant has provided Landlord with reasonable evidence that there is sufficient funding to pay for
such Alteration, and (y) Tenant has required its general contractor to obtain appropriate surety payment and performance bonds which shall name Landlord as an additional obligee and has filed lien bond(s) (in jurisdictions where available) on
behalf of such contractors. Any mechanic’s lien filed against the Premises or the Building for work claimed to have been done for, or materials claimed to have been furnished to, Tenant shall be discharged by Tenant within ten
(10) business days thereafter, at Tenant’s expense by filing the bond required by law or otherwise. 
 11.4 General
Requirements. Unless Landlord and Tenant otherwise agree in writing, Tenant shall (a) procure or cause others to procure on its behalf all necessary permits before undertaking any Alterations in the Premises (and provide copies thereof to
Landlord); (b) perform all of such Alterations in a good and workmanlike manner, employing materials of good quality and in compliance with Landlord’s construction rules and regulations, all insurance requirements of this Lease, and Legal
Requirements; and (c) defend, indemnify and hold the Landlord Parties harmless from and against any and all Claims occasioned by or growing out of such Alterations, except to the extent caused by the negligence or willful misconduct of any
Landlord Parties. 
  

	12.	 SIGNAGE 

12.1 Restrictions. Tenant shall have the right to install Building standard signage identifying Tenant’s business at the entrance
to the Premises, which signage shall be subject to Landlord’s prior written consent (which consent shall not be unreasonably withheld, conditioned or delayed). Subject to the foregoing, and subject to Section 12.2 below, Tenant shall not,
without first obtaining Landlord’s written approval, place or suffer to be placed or maintained: (i) any sign, banner, advertising matter or any other thing of any kind (including, without limitation, any hand-lettered advertising) which
is either located on the exterior of the Premises, or on any part of the interior of the Premises which is visible from the exterior of the Building, or (ii) any decoration, letter or advertising matter on the glass of any window or door of the
Premises. 

  
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 12.2 Monument Signage. Subject to the provisions of this Section 12.2, for so
long as the Lease is in full force and effect (the “Monument Signage Condition”), then Tenant shall have the right to require Landlord to list, at Tenant’s cost and expense, Tenant’s name (“Tenant’s
Monument Signage”) on the existing exterior monument sign (the “Monument Sign”) in the location set forth on Exhibit 13 attached hereto, during the initial Term of the Lease, and any extensions
thereof, subject to the provisions of this Section 12.2. The parties hereby agree that the maintenance and removal of such Tenant’s Monument Signage (including, without limitation, the repair and cleaning of the existing monument
façade upon removal of Tenant’s Monument Signage) shall be performed at Tenant’s sole cost and expense, and Tenant shall be responsible for the cost of any change in Tenant’s Monument Signage during the initial Term of the
lease; provided, however, Tenant shall be entitled to apply Landlord’s Contribution toward the cost of any Monument Signage or suite entry signage allowed pursuant to Section 12.1 above. 

12.3 Building Directory/Premises Entrance Signage. During the Term of the Lease: 

(a) Landlord shall install a tenant directory in the Building lobby, and shall list Tenant’s name on such directory. The initial listing
shall be at Landlord’s cost and expense, but any changes to such directory listing shall be at Tenant’s cost and expense. 
 (b)
Tenant shall have the right, at Tenant’s cost (although such cost may be paid for out of Landlord’s Contribution) to install a building standard Tenant identification sign at the entrance to the Premises. 

 

	13.	 ASSIGNMENT, MORTGAGING AND SUBLETTING 

13.1 Landlord’s Consent Required. Tenant shall not mortgage or encumber this Lease or in whole or in part whether at one
time or at intervals, operation of law or otherwise. Except as expressly otherwise set forth herein, Tenant shall not, without Landlord’s prior written consent, assign, sublet, license or transfer this Lease or the Premises in whole or in part
whether by changes in the ownership or control of Tenant, or any direct or indirect owner of Tenant, whether at one time or at intervals, by sale or transfer of stock, partnership or beneficial interests, operation of law or otherwise, or permit the
occupancy of all or any portion of the Premises by any person or entity other than Tenant’s employees (each of the foregoing, a “Transfer”). Any purported Transfer made without Landlord’s consent, if required
hereunder, shall be void and confer no rights upon any third person, provided that if there is a Transfer, Landlord may collect rent from the transferee without waiving the prohibition against Transfers, accepting the transferee, or releasing Tenant
from full performance under this Lease. In the event of any Transfer in violation of this Section 13, Landlord shall have the right to terminate this Lease upon thirty (30) days’ written notice to Tenant given within sixty
(60) days after receipt of written notice from Tenant to Landlord of any Transfer, or within one (1) year after Landlord first learns of the Transfer if no notice is given. No Transfer shall relieve Tenant of its primary obligation as
party Tenant hereunder, nor shall it reduce or increase Landlord’s obligations under this Lease. 
 13.2 Landlord’s Recapture
Right. Except in the event of any Permitted Transfer, as defined in Section 13.7, Tenant shall, prior to offering or advertising the Premises or any portion thereof for a Transfer, give a written notice (the “Recapture
Notice”) to Landlord which: (i) states that Tenant desires to make a Transfer, (ii) identifies the affected portion of the Premises (the “Recapture Premises”), (iii) identifies the period of
time (the “Recapture Period”) during 

  
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which Tenant proposes to sublet the Recapture Premises, or indicates that Tenant proposes to assign its interest in this Lease, and (iv) offers to Landlord to terminate this Lease with
respect to the Recapture Premises (in the case of a proposed assignment of Tenant’s interest in this Lease or a subletting for the remainder of the term of this Lease) or to suspend the Term for the Recapture Period (i.e. the Term with respect
to the Recapture Premises shall be terminated during the Recapture Period and Tenant’s rental obligations shall be proportionately reduced). Landlord shall have fifteen (15) business days within which to respond to the Recapture Notice.

 13.3 Standard of Consent to Transfer. If Landlord does not timely give written notice to Tenant accepting a Recapture Offer
or declines to accept the same, then Landlord agrees that, subject to the provisions of this Section 13, Landlord shall not unreasonably withhold, condition or delay its consent to a Transfer on the terms contained in the Recapture Notice to an
entity which will use the Premises for any of the Permitted Uses. Without limiting the reasonable reasons why Landlord may withhold its consent to a proposed Transfer, it shall be reasonable for Landlord to withhold its consent to a proposed
Transfer if, in Landlord’s reasonable opinion: (a) the Proposed Transferee does not have a tangible net worth and other financial indicators sufficient to meet the Transferee’s obligations under the Transfer instrument in question;
(b) the Proposed Transferee has a business reputation that is not compatible with the operation of a first-class combination laboratory, research, development and office building; or (c) the intended use of such entity violates any
restrictive use provisions then in effect with respect to space in the Building. 
 13.4 Listing Confers no Rights. The
listing of any name other than that of Tenant, whether on the doors of the Premises or on the Building directory, or otherwise, shall not operate to vest in any such other person, firm or corporation any right or interest in this Lease or in the
Premises or be deemed to effect or evidence any consent of Landlord, it being expressly understood that any such listing is a privilege extended by Landlord revocable at will by written notice to Tenant. 

13.5 Profits In Connection with Transfers. Except with respect to any Permitted Transfers, as defined in Section 13.7, and
with respect to Flagship Subleases, as defined in Section 13.8, Tenant shall, within thirty (30) days of receipt thereof, pay to Landlord fifty percent (50%) of any rent, sum or other consideration to be paid or given in connection with
any Transfer, either initially or over time, after deducting reasonable actual out-of-pocket legal, and brokerage expenses incurred by Tenant and unamortized
improvements paid for by Tenant in connection therewith and any rental concessions, in excess of Rent hereunder as if such amount were originally called for by the terms of this Lease as Additional Rent. 

13.6 Prohibited Transfers. Notwithstanding any contrary provision of this Lease, Tenant shall have no right to make a Transfer
unless on both (i) the date on which Tenant notifies Landlord of its intention to enter into a Transfer and (ii) the date on which such Transfer is to take effect, there is no Event of Default under this Lease. Notwithstanding anything to
the contrary contained herein, Tenant agrees that in no event shall Tenant make a Transfer to (a) any government agency; (b) any tenant, subtenant or occupant of other space in the Building if vacant space of a size comparable to the
portion of the Premises subject to the Transfer then exists in the Building; or (c) any entity with whom Landlord shall have negotiated for space in the Property in the three (3) months immediately preceding such proposed Transfer. 

  
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 13.7 Exceptions to Requirement for Consent. Notwithstanding anything to the
contrary herein contained, Tenant shall have the right, without obtaining Landlord’s consent, and without giving Landlord a Recapture Notice, to (a) make a Transfer to an Affiliated Entity (hereinafter defined) so long as the transfer to
such Affiliated Entity is for legitimate business purposes (and not for the purpose of avoiding the provisions of this Section 13), and (b) assign all of Tenant’s interest in and to the Lease to a Successor, provided that prior to or
simultaneously with any assignment pursuant to this Section 13.7, such Affiliated Entity or Successor, as the case may be, and Tenant execute and deliver to Landlord an assignment and assumption agreement in form and substance reasonably
acceptable to Landlord whereby such Affiliated Entity or Successor, as the case may be, shall agree to be independently bound by and upon all the covenants, agreements, terms, provisions and conditions set forth in the Lease on the part of Tenant to
be performed, and whereby such Affiliated Entity or Successor, as the case may be, shall expressly agree that the provisions of this Section 13 shall, notwithstanding such Transfer, continue to be binding upon it with respect to all future
Transfers. For the purposes hereof, an “Affiliated Entity” shall be defined as any entity which is controlled by, is under common control with, or which controls Tenant. For the purposes hereof, a
“Successor” shall be defined as any entity into or with which Tenant is merged or with which Tenant is consolidated or which acquires all or substantially all of Tenant’s stock or assets, provided that the
surviving entity shall have a net worth and other financial indicators sufficient to meet Tenant’s obligations hereunder. Tenant shall give Landlord at least ten (10) days’ prior written notice of any Permitted Transfer, such notice
to include evidence, reasonably satisfactory to Landlord, that the conditions to the Permitted Transfer in question have been satisfied. Transfers to Affiliated Entities and to Successors which are permitted pursuant to this Section 13.7, and
Transfers to Flagship Entities which permitted pursuant to Section 13.8 below, are referred to collectively herein as “Permitted Transfers”, and such Affiliated Entities, Flagship Entities, and Successors are
referred to herein as “Permitted Transferees”. 
 13.8 Flagship Subleases. Notwithstanding
anything to the contrary herein contained, Tenant shall have the right, upon at least ten (10) days’ prior written notice from Tenant to Landlord, without obtaining Landlord’s consent, and without giving Landlord a Recapture Notice,
to enter into Flagship Subleases, as hereinafter defined. A “Flagship Sublease” shall be defined as a sublease or license of Internal Sublet Space, as hereinafter defined, to Flagship Entities, as hereinafter defined,
provided however, that: (i) at no time shall more than 15,000 rentable square feet of the Premises, in the aggregate, be subject to Flagship Subleases, and (ii) no sublease or license shall be considered to be a Flagship Sublease if it is
entered into for the purposes of avoiding the operation of the provisions of this Article 13 (e.g., without limitation, the requirement of obtaining Landlord’s consent to such sublease, Landlord’s recapture rights, etc.). A
“Flagship Entity” shall be defined as any person or entity operating a business which, as of the date of that such person or entity first occupies any portion of the Premises pursuant to its Flagship Sublease, has been
provided funding from Flagship Pioneering (formerly known as Flagship Ventures) which is either: (i) more than fifty (50%) percent of the total funding received by such person or entity, or (ii) $1,000,000. An “Internal Sublet
Space” shall consist of an area located in the Premises which has access to the common areas of the Building only through Tenant’s reception area. 

  
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	14.	 INSURANCE; INDEMNIFICATION; EXCULPATION 

14.1 Tenant’s Insurance.

(a) Tenant shall procure, pay for and keep in force throughout the Term (and for so long thereafter as Tenant remains in occupancy of the
Premises) commercial general liability insurance insuring Tenant on an occurrence basis against all claims and demands for personal injury liability (including, without limitation, bodily injury, sickness, disease, and death) or damage to property
which may be claimed to have occurred from and after the time any of the Tenant Parties shall first enter the Premises, of not less than Two Million Dollars ($2,000,000) per occurrence and Four Million Dollars ($4,000,000) in the aggregate annually,
and from time to time thereafter shall be not less than such higher amounts, if procurable, as may be reasonably required by Landlord. Tenant shall also carry umbrella liability coverage in an amount of no less than Three Million Dollars
($3,000,000). Such policy shall also include contractual liability coverage covering Tenant’s liability assumed under this Lease, including without limitation Tenant’s indemnification obligations. Such insurance policy(ies) shall name
Landlord, Landlord’s managing agent and persons claiming by, through or under them, if any, as additional insureds. 
 (b) Tenant shall
take out and maintain throughout the Term a policy of fire, vandalism, malicious mischief, extended coverage and so-called “all risk” coverage insurance in an amount equal to one hundred percent
(100%) of the replacement cost insuring (i) all items or components of Alterations (collectively, the “Tenant-Insured Improvements”), and (ii) all of Tenant’s furniture, equipment, fixtures and
property of every kind, nature and description related or arising out of Tenant’s leasehold estate hereunder, which may be in or upon the Premises or the Building (collectively, “Tenant’s
Property”). The insurance required to be maintained by Tenant pursuant to this Section 14.1(b) (referred to herein as “Tenant Property Insurance”) shall insure the interests of both
Landlord and Tenant as their respective interests may appear from time to time. 
 (c) Tenant shall take out and maintain a policy of
business interruption insurance throughout the Term sufficient to cover at least twelve (12) months of Rent due hereunder and Tenant’s business losses during such 12-month period. 

(d) During periods when Tenant’s Work and/or any Alterations are being performed, Tenant shall maintain, or cause to be maintained, so-called all risk or special cause of loss property insurance or its equivalent and/or builders risk insurance on 100% replacement cost coverage basis, including hard and soft costs coverages. Such insurance shall
protect and insure Landlord, Landlord’s agents, Tenant and Tenant’s contractors, as their interests may appear, against loss or damage by fire, water damage, vandalism and malicious mischief, and such other risks as are customarily covered
by so-called all risk or special cause of loss property / builders risk coverage or its equivalent. 

(e) Tenant shall procure and maintain at its sole expense such additional insurance as may be necessary to comply with any Legal Requirements.

  
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 (f) Tenant shall cause all contractors and subcontractors to maintain during the performance
of any Alterations the insurance described in Exhibit 10 attached hereto. 
 (g) The insurance required pursuant to Sections 14.1(a),
(b), (c), (d) and (e) (collectively, “Tenant’s Insurance Policies”) shall be effected with insurers approved by Landlord, with a rating of not less than “A-XI” in
the current Best’s Insurance Reports, and authorized to do business in the Commonwealth of Massachusetts under valid and enforceable policies. Tenant’s Insurance Policies shall each provide that it shall not be canceled or modified
without at least ten (10) days’ prior written notice to each insured named therein; provided, however, in the event Tenant’s insurer will not provide such notice, Tenant shall be obligated to provide Landlord with ten
(10) days’ prior written notice of any cancellation or modification. Tenant’s Insurance Policies may include deductibles in an amount no greater than the greater of $25,000 or commercially reasonable amounts. On or before the date on
which any of the Tenant Parties shall first enter the Premises and thereafter not less than five (5) days prior to the expiration date of each expiring policy, Tenant shall deliver to Landlord binders of Tenant’s Insurance Policies issued
by the respective insurers setting forth in full the provisions thereof together with evidence satisfactory to Landlord of the payment of all premiums for such policies. In the event of any claim, and upon Landlord’s request, Tenant shall
deliver to Landlord complete copies of Tenant’s Insurance Policies. Upon request of Landlord, Tenant shall deliver to any Mortgagee copies of the foregoing documents. 

14.2 Indemnification. Except to the extent caused by the negligence or willful misconduct of any of the Landlord Parties, Tenant
shall defend, indemnify and save the Landlord Parties harmless from and against any and all Claims asserted by or on behalf of any person, firm, corporation or public authority arising from: 

(a) Tenant’s breach of any covenant or obligation under this Lease; 

(b) Any injury to or death of any person, or loss of or damage to property, sustained or occurring in, at or upon the Premises; 

(c) Any injury to or death of any person, or loss of or damage to property arising out of the use or occupancy of the Premises by or the
negligence or willful misconduct of any of the Tenant Parties; and 
 (d) On account of or based upon any work or thing whatsoever done
(other than by Landlord or any of the Landlord Parties) at the Premises during the Term and during the period of time, if any, prior to the Term Commencement Date that any of the Tenant Parties may have been given access to the Premises. 

14.3 Property of Tenant. Tenant covenants and agrees that, to the maximum extent permitted by Legal Requirements, all of
Tenant’s Property at the Premises shall be at the sole risk and hazard of Tenant, and that if the whole or any part thereof shall be damaged, destroyed, stolen or removed from any cause or reason whatsoever, no part of said damage or loss shall
be charged to, or borne by, Landlord, except, subject to Section 14.5 hereof, to the extent such damage or loss is due to the negligence or willful misconduct of any of the Landlord Parties. 

  
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 14.4 Limitation of Landlord’s Liability for Damage or Injury. Landlord
shall not be liable for any injury or damage to persons or property resulting from fire, explosion, falling plaster, steam, gas, air contaminants or emissions, electricity, electrical or electronic emanations or disturbance, water, rain or snow or
leaks from any part of the Building or from the pipes, appliances, equipment or plumbing works or from the roof, street or sub-surface or from any other place or caused by dampness, vandalism, malicious
mischief or by any other cause of whatever nature, except, subject to Section 14.5, to the extent caused by or due to the negligence or willful misconduct of any of the Landlord Parties, and then, where notice and an opportunity to cure are
appropriate (i.e., where Tenant has an opportunity to know of such condition sufficiently in advance of the occurrence of any such injury or damage resulting therefrom as would have enabled Landlord to prevent such damage or loss had Tenant notified
Landlord of such condition) only after (i) notice to Landlord of the condition claimed to constitute negligence or willful misconduct, and (ii) the expiration of a reasonable time after such notice has been received by Landlord without
Landlord having commenced to take all reasonable and practicable means to cure or correct such condition. Notwithstanding the foregoing, in no event shall any of the Landlord Parties be liable for any loss which is covered by insurance policies
actually carried or required to be so carried by this Lease; nor shall any of the Landlord Parties be liable for any such damage caused by other tenants or persons in the Building or caused by operations in construction of any private, public, or
quasi-public work; nor shall any of the Landlord Parties be liable for any latent defect in the Premises or in the Building. 
 14.5
Waiver of Subrogation; Mutual Release. Landlord and Tenant each hereby waives on behalf of itself and its property insurers (none of which shall ever be assigned any such claim or be entitled thereto due to subrogation or otherwise) any
and all rights of recovery, claim, action, or cause of action against the other and its agents, officers, servants, partners, shareholders, or employees (collectively, the “Related Parties”) for any loss or damage that
may occur to or within the Premises or the Building or any improvements thereto, or any personal property of such party therein which is insured against under any Property Insurance (as defined in Section 14.7) policy actually being maintained
by the waiving party from time to time, even if not required hereunder, or which would be insured against under the terms of any Property Insurance policy required to be carried or maintained by the waiving party hereunder, whether or not such
insurance coverage is actually being maintained, including, in every instance, such loss or damage that may be caused by the negligence of the other party hereto and/or its Related Parties. Landlord and Tenant each agrees to cause appropriate
clauses to be included in its Property Insurance policies necessary to implement the foregoing provisions. For avoidance of doubt, each party (“Waiving Party”) expressly waives any claim which it might have
against the other party (“Released Party”) for damage to property which is not covered by reason of any deductible or self-insured retention under the Waiving Party’s Property Insurance, or by reason of the fact
that the Waiving Party is self-insuring damage to its property. 
 14.6 Tenant’s Acts—Effect on Insurance. Tenant
shall not do or permit any Tenant Party to do any act or thing upon the Premises or elsewhere in the Building which will invalidate or be in conflict with any insurance policies covering the Building and the fixtures and property therein; and shall
not do, or permit to be done, any act or thing upon the Premises which shall subject Landlord to any liability or responsibility for injury to any person or persons or to property by reason of any business or operation being carried on upon said
Premises or for any other reason. Notwithstanding anything to the contrary contained herein, Tenant shall not be 

  
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liable for any increases in the rate of insurance unless such increases arise from Tenant’s manner of use of the Premises (as opposed to Tenant’s use of the Premises for the Permitted
Uses). If by reason of the failure of Tenant to comply with the provisions hereof the insurance rate applicable to any policy of insurance shall at any time thereafter be higher than it otherwise would be, Tenant shall reimburse Landlord within
thirty (30) days of Landlord’s written demand for that part of any insurance premiums which shall have been charged because of such failure by Tenant, together with interest at the Default Rate until paid in full, within thirty
(30) days after receipt of an invoice therefor. In addition, Tenant shall reimburse Landlord for any increase in insurance premium arising as a result of Tenant’s use and/or storage of any Hazardous Materials in the Premises. 

14.7 Landlord’s Insurance. Landlord shall carry at all times during the Term of this Lease: (i) commercial general liability
insurance with respect to the Building, the Land and the Common Areas thereof in an amount not less than Five Million Dollars ($5,000,000) combined single limit per occurrence, (ii) with respect to the Building, excluding Tenant-Insured
Improvements and improvements made by other tenants or occupants, insurance against loss or damage caused by any peril covered under fire, extended coverage and all risk insurance with coverage against vandalism, malicious mischief and such other
insurable hazards and contingencies as are from time to time normally insured against by owners of similar first class offices/research/laboratory buildings/campuses in the Route 128/Route 2/Alewife corridor real estate market or which are required
by Landlord’s mortgagee, in an amount equal to one hundred percent (100%) of the full replacement cost thereof above foundation walls (“Landlord Property Insurance”), and (iii) rent interruption insurance covering at least
twelve (12) months. Any and all such insurance: (x) may be maintained under a blanket policy affecting other properties of Landlord and/or its affiliated business organizations, and (y) may be written with commercially reasonable
deductibles as determined by Landlord. The costs incurred by Landlord related to such insurance shall be included in Operating Costs. Tenant Property Insurance and Landlord Property Insurance are referred to collectively herein as “Property
Insurance”. 
  

	15.	 CASUALTY; TAKING 

15.1 Damage. If the Premises are damaged in whole or part because of fire or other insured casualty (“Casualty”), or if
the Premises are subject to a taking in connection with the exercise of any power of eminent domain, condemnation, or purchase under threat or in lieu thereof (any of the foregoing, a “Taking”), then unless this Lease is terminated
in accordance with Section 15.2 below, Landlord shall restore the Building and/or the Premises to substantially the same condition as existed immediately following completion of Landlord’s Work, or in the event of a partial Taking which
affects the Building and the Premises, restore the remainder of the Building and the Premises not so Taken to substantially the same condition as is reasonably feasible. Landlord shall, within sixty (60) days after any Casualty, deliver to
Tenant an engineering estimate (“Restoration Estimate”) from a reputable contractor or engineer, setting forth an estimate of the period of time (“Restoration Period”) that it will take for Landlord to restore the
Building and/or Premises, as aforesaid. If, in Landlord’s reasonable judgment, any element of the Tenant-Insured Improvements can more effectively be restored as an integral part of Landlord’s restoration of the Building or the Premises,
such restoration shall also be made by Landlord, but at Tenant’s sole cost and expense. Subject to rights of Mortgagees, Tenant Delays, 

  
 PAGE 39 

 Legal Requirements then in existence and to delays for adjustment of insurance proceeds or Taking awards, as
the case may be, and instances of Force Majeure, Landlord shall substantially complete such restoration within one (1) year after Landlord’s receipt of all required permits therefor with respect to substantial reconstruction
of at least 50% of the Building, or, within one hundred eighty (180) days after Landlord’s receipt of all required permits therefor in the case of restoration of less than 50% of the Building. Upon substantial completion of
such restoration by Landlord, Tenant shall use diligent efforts to complete restoration of the Premises to substantially the same condition as existed immediately prior to such Casualty or Taking, as the case may be, as soon as reasonably possible.
Tenant agrees to cooperate with Landlord in such manner as Landlord may reasonably request to assist Landlord in collecting insurance proceeds due in connection with any Casualty which affects the Premises or the Building. In no event shall Landlord
be required to expend more than the Net (hereinafter defined) insurance proceeds Landlord receives for damage to the Premises and/or the Building or the Net Taking award attributable to the Premises and/or the Building. “Net” means
the insurance proceeds or Taking award actually paid to Landlord (and not paid over to a Mortgagee) less all costs and expenses, including adjusters and attorney’s fees, of obtaining the same. In the Operating Year in which a
Casualty occurs, there shall be included in Operating Costs Landlord’s deductible under its property insurance policy. Except as Landlord may elect pursuant to this Section 15.1, under no circumstances shall Landlord be
required to repair any damage to, or make any repairs to or replacements of, any Tenant-Insured Improvements. 
 15.2 Termination
Rights. 
 (a) Landlord’s Termination Rights. Landlord may terminate this Lease upon thirty (30) days’ prior
written notice to Tenant if: 
 (i) any material portion of the Building or any material means of access thereto is taken;

 (ii) more than thirty-five percent (35%) of the Building is damaged by Casualty; or 

(iii) if the estimated time to complete restoration exceeds one (1) year from the date on which Landlord receives all
required permits for such restoration. 
 (b) Tenant’s Termination Rights. Tenant may terminate this Lease upon thirty (30)
days’ prior written notice to Landlord if: 
 (i) any material portion of the Premises or any material means of access
thereto is taken, so that, in Tenant’s reasonable judgment, the continued operation of Tenant’s business in the Premises is materially adversely affected; 

(ii) if, 50% or more of the Building is damaged by a Casualty and the estimated Restoration Period, as set forth in the
Restoration Estimate, exceeds one (1) year from the date on which Landlord receives all required permits for such restoration; or 

  
 PAGE 40 

 (iii) if less than 50% of the Building is damaged by a Casualty,
Tenant’s use of and/or access to the Premises is materially adversely affected by such Casualty, estimated Restoration Period, as set forth in the Restoration Estimate, exceeds six (6) months from the date on which Landlord receives all
required permits for such restoration; and the 
 (iv) if Landlord is so required but fails to complete restoration of the
Premises within the time frames and subject to the conditions set forth in Section 15.1 above, then Tenant may terminate this Lease upon thirty (30) days written notice to Landlord; provided, however, that if Landlord completes such
restoration within thirty (30) days after receipt of any such termination notice on account of Landlord’s failure to so complete within the time period required, such termination notice shall be null and void and this Lease shall continue
in full force and effect. 
 The remedies set forth in this Section 15.2(b) and in Section 15.2(c) below are
Tenant’s sole and exclusive rights and remedies based upon Landlord’s failure to complete the restoration of the Premises as set forth herein. 

(c) Either Party May Terminate. In the case of any Casualty or Taking affecting the Premises and occurring during the last twelve
(12) months of the Term, then either Landlord or Tenant shall have the option to terminate this Lease upon thirty (30) days’ written notice to the other. In addition, if Landlord’s Mortgagee does not release sufficient insurance
proceeds to cover the cost of Landlord’s restoration obligations, then Landlord shall (i) notify Tenant thereof, and (ii) have the right to terminate this Lease. If Landlord does not terminate this Lease pursuant to the previous
sentence and such notice by Landlord does not include an agreement by Landlord to pay for the difference between the cost of such restoration and such released insurance proceeds, then Tenant may terminate this Lease by written notice to Landlord on
or before the date that is thirty (30) days after such notice. 
 (d) Automatic Termination. In the case of a Taking of the
entire Premises, then this Lease shall automatically terminate as of the date of possession by the Taking authority. 
 15.3 Rent
Abatement. In the event of a Casualty affecting the Premises, there shall be an equitable adjustment of Base Rent, Operating Costs and Taxes based upon the degree to which Tenant’s ability to conduct its business in the
Premises is impaired by reason of such Casualty from and after the date of a Casualty, and continuing until the following portions of the repair and restoration work to be performed by Landlord, as set forth above, are substantially completed:
(i) any repair and restoration work to be performed by Landlord within the Premises, and (ii) repair and restoration work with respect to the Common Areas to the extent that damage to the Common Areas caused by such Casualty materially
adversely affects Tenant’s use of, or access to, the Premises. 
 15.4 Taking for Temporary Use. If the Premises
are Taken for temporary use, this Lease and Tenant’s obligations, including without limitation the payment of Rent, shall continue. For purposes hereof, a “Taking for temporary use” shall mean a Taking of ninety
(90) days or less. 

  
 PAGE 41 

 15.5 Disposition of Awards. Except for any separate award for
Tenant’s movable trade fixtures, relocation expenses, and unamortized leasehold improvements paid for by Tenant (provided that the same may not reduce Landlord’s award), all Taking awards to Landlord or Tenant
shall be Landlord’s property without Tenant’s participation, and Tenant hereby assigns to Landlord Tenant’s interest, if any, in such award. Tenant may pursue its own claim against the Taking
authority. 
  

	16.	 ESTOPPEL CERTIFICATE. 

Tenant shall at any time and from time to time upon not less than ten (10) business days’ prior notice from Landlord, execute,
acknowledge and deliver to Landlord a statement in writing certifying that this Lease is unmodified and in full force and effect (or if there have been modifications, that the same is in full force and effect as modified and stating the
modifications), and the dates to which Rent has been paid in advance, if any, stating to Tenant’s knowledge whether or not Landlord is in default in performance of any covenant, agreement, term, provision or condition contained in this Lease
and, if so, specifying each such default, and such other facts as Landlord may reasonably request, it being intended that any such statement delivered pursuant hereto may be relied upon by Landlord, any prospective purchaser of the Building or of
any interest of Landlord therein, any Mortgagee or prospective Mortgagee thereof, any lessor or prospective lessor thereof, any lessee or prospective lessee thereof, or any prospective assignee of any mortgage thereof. Time is of the essence with
respect to any such requested certificate, Tenant hereby acknowledging the importance of such certificates in mortgage financing arrangements, prospective sales and the like. 

 

	17.	 HAZARDOUS MATERIALS 

17.1 Prohibition. Tenant shall not, without the prior written consent of Landlord, bring or permit to be brought or kept in or on the
Premises or elsewhere in the Building or the Property (i) any inflammable, combustible or explosive fluid, material, chemical or substance (except for standard office supplies stored in proper containers); and (ii) any Hazardous Material
(hereinafter defined), other than the types and quantities of Hazardous Materials which are listed on Exhibit 8 attached hereto (“Tenant’s Hazardous Materials”), provided that: 

(x) Tenant’s Hazardous Materials shall at all times be brought upon, kept or used in
so-called ‘control areas’ (the number and size of which shall be reasonably determined by Landlord) and in accordance with all applicable Environmental Laws (hereinafter
defined) and prudent environmental practice and (with respect to medical waste and so-called “biohazard” materials) good scientific and medical practice; and 

(y) each of sodium azide, diethy ether, and picric acid may only be brought, kept or used in the Premises so long as such chemicals are used,
stored, handled and transported in accordance with a materials use and storage plan proposed by Tenant and which is approved by Landlord, which approval shall not be unreasonably withheld, conditioned, or delayed. 

  
 PAGE 42 

 Tenant shall be responsible for assuring that all laboratory uses are adequately and properly vented. On or
before each anniversary of the Rent Commencement Date, and on any earlier date during the 12-month period on which Tenant intends to add a new Hazardous Material or materially increase the quantity of any
Hazardous Material to the list of Tenant’s Hazardous Materials, Tenant shall submit to Landlord an updated list of Tenant’s Hazardous Materials for Landlord’s review and approval, which
approval shall not be unreasonably withheld, conditioned or delayed. Landlord shall have the right, from time to time, to inspect the Premises for compliance with the terms of this Section 17.1. Notwithstanding the foregoing, with respect to
any of Tenant’s Hazardous Materials which Tenant does not properly handle, store or dispose of in compliance with all applicable Environmental Laws (hereinafter defined), prudent environmental practice and (with respect to medical
waste and so-called “biohazard materials”) good scientific and medical practice, Tenant shall, upon written notice from Landlord, no longer have the right to bring such
material into the Building or the Property until Tenant has demonstrated, to Landlord’s reasonable satisfaction, that Tenant has implemented programs to thereafter properly handle, store or dispose of such material. In order to
induce Landlord to waive its otherwise applicable requirement that Tenant maintain insurance in favor of Landlord against liability arising from the presence of radioactive materials in the Premises, and without limiting the foregoing, Tenant hereby
represents and warrants to Landlord that at no time during the Term will Tenant bring upon, or permit to be brought upon, the Premises any radioactive materials whatsoever. 

17.2 Environmental Laws. For purposes hereof, “Environmental Laws” shall mean all laws, statutes, ordinances, rules
and regulations of any local, state or federal governmental authority having jurisdiction concerning environmental, health and safety matters, including but not limited to any discharge by any of the Tenant Parties into the air, surface water,
sewers, soil or groundwater of any Hazardous Material (hereinafter defined) whether within or outside the Premises, including, without limitation (a) the Federal Water Pollution Control Act, 33 U.S.C. Section 1251 et seq., (b) the Federal
Resource Conservation and Recovery Act, 42 U.S.C. Section 6901 et seq., (c) the Comprehensive Environmental Response, Compensation and Liability Act, 42 U.S.C. Section 9601 et seq., (d) the Toxic Substances Control Act of 1976, 15 U.S.C.
Section 2601 et seq., and (e) Chapter 21E of the General Laws of Massachusetts. Tenant, at its sole cost and expense, shall comply with (i) Environmental Laws, and (ii) any rules, requirements and safety procedures of the
Massachusetts Department of Environmental Protection, the Town of Lexington and any insurer of the Building or the Premises with respect to Tenant’s use, storage and disposal of any Hazardous Materials. 

17.3 Hazardous Material Defined. As used herein, the term “Hazardous Material” means asbestos, oil or any hazardous,
radioactive or toxic substance, material or waste or petroleum derivative which is or becomes regulated by any Environmental Law, including without limitation live organisms, viruses and fungi, medical waste and any
so-called “biohazard” materials. The term “Hazardous Material” includes, without limitation, oil and/or any material or substance which is
(i) designated as a “hazardous substance,” “hazardous material,” “oil,” “hazardous waste” or
toxic substance under any Environmental Law. 
 17.4 Chemical Safety Program. Tenant shall establish and maintain a chemical safety
program administered by a licensed, qualified individual in accordance with the requirements of any applicable governmental authority. Tenant shall be solely responsible for all costs incurred in connection with such chemical safety program, and
Tenant shall provide Landlord with such documentation as Landlord may reasonably require evidencing Tenant’s compliance with the requirements of (a) any applicable governmental authority with respect to such chemical safety
program and (b) this Section. Tenant shall obtain and maintain during the Term any permit required by any such applicable governmental authority. 

  
 PAGE 43 

 17.5 Testing. If any Mortgagee or governmental authority requires testing to
determine whether there has been any release of Hazardous Materials and such testing is required as a result of the acts or omissions of any of the Tenant Parties in violation of this Lease, then Tenant shall reimburse Landlord within thirty
(30) days of Landlord’s written demand, as Additional Rent, for the reasonable costs thereof, together with interest at the Default Rate until paid in full. Tenant shall execute affidavits, certifications and the like, as may
be reasonably requested by Landlord from time to time concerning Tenant’s best knowledge and belief concerning the presence of Hazardous Materials in or on the Premises, the Building or the Property. In addition to the foregoing, if Landlord
reasonably believes that any Hazardous Materials have been released on the Premises in violation of this Lease or any Legal Requirement, Landlord shall have the right to conduct appropriate tests of the Premises or any portion thereof to demonstrate
that Hazardous Materials are present or that contamination has occurred due to the acts or omissions of any of the Tenant Parties. Tenant shall pay all reasonable costs of such tests if such tests reveal that Hazardous Materials exist at the
Premises in violation of this Lease or any Legal Requirement. Further, Landlord shall have the right to cause a third party consultant retained by Landlord, at Landlord’s expense (provided, however, that such costs shall be
included in Operating Costs, if allowable pursuant to Section 5.2), to review, but not more than once in any calendar year, Tenant’s lab operations, procedures and permits to ascertain whether or not Tenant is complying with
law and adhering to best industry practices. Tenant agrees to cooperate in good faith with any such review and to provide to such consultant any information requested by such consultant and reasonably required in order for such consultant to perform
such review, but nothing contained herein shall require Tenant to provide proprietary or confidential information to such consultant. 

17.6 Indemnity; Remediation. 

(a) Tenant hereby covenants and agrees to indemnify, defend and hold the Landlord Parties harmless from and against any and all Claims against
any of the Landlord Parties arising out of contamination of any part of the Property or other adjacent property, which contamination arises as a result of: (i) the presence of Hazardous Material in the Premises, the presence of which is caused
by any act or omission of any of the Tenant Parties, or (ii) from a breach by Tenant of its obligations under this Section 17. This indemnification of the Landlord Parties by Tenant includes, without limitation, reasonable costs incurred
in connection with any investigation of site conditions or any cleanup, remedial, removal or restoration work or any other response actions required by any federal, state or local governmental agency or political subdivision because of Hazardous
Material present in the soil, soil vapor or ground water on or under or any indoor air in the Building based upon the circumstances identified in the first sentence of this Section 17.6. The indemnification and hold harmless obligations of
Tenant under this Section 17.6 shall survive the expiration or any earlier termination of this Lease. Without limiting the foregoing, if the presence of any Hazardous Material in the Building or otherwise in the Property is caused or permitted
by any of the Tenant Parties and results in any contamination of any part of the Property or any adjacent property, Tenant shall promptly take all actions at Tenant’s sole cost and expense as are necessary to return the Property and/or the

  
 PAGE 44 

 
Building or any adjacent property to their condition as of the date of this Lease, provided that Tenant shall first obtain Landlord’s written approval of such actions, which approval shall
not be unreasonably withheld, conditioned or delayed so long as such actions, in Landlord’s reasonable discretion, would not potentially have any adverse effect on the Property, and, in any event, Landlord shall not withhold its approval of any
proposed actions which are required by applicable Environmental Laws. The provisions of this Section 17.6 shall survive the expiration or earlier termination of the Lease. 

(b) Without limiting the obligations set forth in Section 17.6(a) above, if any Hazardous Material is in, on, under, at or about the
Building or the Property as a result of the acts or omissions of any of the Tenant Parties and results in any contamination of any part of the Property or any adjacent property that is in violation of any applicable Environmental Law or that
requires the performance of any response action pursuant to any Environmental Law, Tenant shall promptly take all actions at Tenant’s sole cost and expense as are necessary to reduce such Hazardous Material to amounts below any applicable
Reportable Quantity, any applicable Reportable Concentration and any other applicable standard set forth in any Environmental Law such that no further response actions are required; provided that Tenant shall first obtain Landlord’s written
approval of such actions, which approval shall not be unreasonably withheld, conditioned or delayed so long as such actions would not be reasonably expected to have an adverse effect on the market value or utility of the Property for the Permitted
Uses, and in any event, Landlord shall not withhold its approval of any proposed actions which are required by applicable Environmental Laws (such approved actions, “Tenant’s Remediation”). 

(c) In the event that Tenant fails to complete Tenant’s Remediation prior to the end of the Term, then: 

(i) until the completion of Tenant’s Remediation (as evidenced by the certification of Tenant’s Licensed Site
Professional (as such term is defined by applicable Environmental Laws), who shall be reasonably acceptable to Landlord) (the “Remediation Completion Date”), Tenant shall pay to Landlord, with respect to the portion of the Premises
which reasonably cannot be occupied by a new tenant until completion of Tenant’s Remediation, (A) Additional Rent on account of Operating Costs and Taxes and (B) Base Rent in an amount equal to the greater of (1) the fair market
rental value of such portion of the Premises (determined in substantial accordance with the process described in Section 1.2 above), and (2) Base Rent attributable to such portion of the Premises in effect immediately prior to the end of
the Term; and 
 (ii) Tenant shall maintain responsibility for Tenant’s Remediation and Tenant shall complete
Tenant’s Remediation as soon as reasonably practicable in accordance with Environmental Laws. If Tenant does not diligently pursue completion of Tenant’s Remediation, Landlord shall have the right to either (A) assume control for
overseeing Tenant’s Remediation, in which event Tenant shall pay all reasonable costs and expenses of Tenant’s Remediation (it being understood and agreed that all costs and expenses of Tenant’s Remediation incurred pursuant to
contracts entered into by Tenant shall be deemed reasonable) within thirty (30) days of demand therefor (which demand shall be made no more often than monthly), and Landlord shall be substituted as the party identified on any governmental
filings as the party responsible for the performance of 

  
 PAGE 45 

 
such Tenant’s Remediation or (B) require Tenant to maintain responsibility for Tenant’s Remediation, in which event Tenant shall complete Tenant’s Remediation as soon as
reasonably practicable in accordance with Environmental Laws, it being understood that Tenant’s Remediation shall not contain any requirement that Tenant remediate any contamination to levels or standards more stringent than those associated
with the Property’s current office, research and development, laboratory, and vivarium uses. 
 (d) The provisions of this
Section 17.6 shall survive the expiration or earlier termination of this Lease. 
 17.7 Disclosures. Prior to bringing any
Hazardous Material into any part of the Property, Tenant shall deliver to Landlord the following information with respect thereto: (a) a description of handling, storage, use and disposal procedures; (b) all plans or disclosures and/or
emergency response plans which Tenant has prepared, including without limitation Tenant’s Spill Response Plan, and all plans which Tenant is required to supply to any governmental agency or authority pursuant to any Environmental Laws;
(c) copies of all Required Permits relating thereto; and (d) other information reasonably requested by Landlord. 
 17.8
Removal. Tenant shall be responsible, at its sole cost and expense, for Hazardous Material and other biohazard disposal services for the Premises. Such services shall be performed by contractors reasonably acceptable to Landlord and on a
sufficient basis to ensure that the Premises are at all times kept neat, clean and free of Hazardous Materials and biohazards except in appropriate, specially marked containers reasonably approved by Landlord. 

17.9 Landlord Obligations with respect to Hazardous Materials. 

(a) Landlord Representations, Covenants and Indemnity. Landlord hereby represents and warrants to Tenant that, to the Best of
Landlord’s Knowledge (as that term is defined in clause (c) below), except to the extent (if any) as may be disclosed in the following described environmental assessment reports which have been made available by Landlord to Tenant (the
“Disclosed Materials”), there exist, as of the Execution Date of this Lease, no Hazardous Materials on the Property which are in violation of applicable Environmental Laws or that require reporting, investigation, remediation
or other response under Chapter 21E or other Environmental Laws: 
  

	 	1.	 Phase I Environmental Site Assessment  

45, 55, 65 Hayden Avenue 

Lexington, MA 02421 
 Prepared
for 
 King Street Properties 

200 Cambridge Park Drive 

Cambridge, MA 02141 
 Prepared
by 
 Boston Environmental Corporation 

338 Howard Street 
 Brockton,
Massachusetts 02302 

  
 PAGE 46 

 July 7, 2016 

Project No. BEC 16-142 
  

	 	2.	 Laboratory Decommissioning Report 

For Merck Sharpe & Dohme Corp. 

65 Hayden Avenue, 1st Floor 

Lexington, MA 
 Prepared for
Ms. Sharon Rose 
 Merck Sharp & Dohme Corp. 

65 Hayden Avenue, First Floor 

Lexington, MA 
 Prepared by
Triumvirate Environmental, Inc. 
 200 Inner Belt Road 

Somerville, MA 02143 
 Job
Number: 703614 
 December 29, 2016 

Landlord covenants that neither Landlord nor any of the Landlord Parties shall bring any Hazardous Materials in or on to the Property or
discharge any Hazardous Materials in or on to the Property which are, in either case, in violation of applicable Environmental Laws. Landlord hereby indemnifies and shall defend and hold Tenant, its officers, directors, employees, and agents
harmless from any Claims arising as result of any breach by Landlord of its representations, warranties, or covenants under this Section 17.9(a). 

(b) Landlord Remediation. If Hazardous Materials are discovered in, on or under the Property which are not in compliance with
applicable Environmental Laws or that require reporting, investigation, remediation or other response under Chapter 21E or other Environmental Laws, and which are not the responsibility of Tenant pursuant to this Article 17, then Landlord shall
remove or remediate the same, when, if, and in the manner required by applicable Environmental Laws. 
 (c) To the Best of
Landlord’s Knowledge. The phrase “to the Best of Landlord’s Knowledge” under shall mean the best of the knowledge of Robert Albro, Landlord’s asset manager with respect to the Property. 

 

	18.	 RULES AND REGULATIONS. 

18.1 Rules and Regulations. Tenant will faithfully observe and comply with the Rules and Regulations attached hereto as Exhibit 9
(“Current Rules and Regulations”) and reasonable rules and regulations as may be promulgated, from time to time, with respect to the Building, the Property and construction within the Property (collectively, the “Rules and
Regulations”). The Current Rules and Regulations consist of the Building Rules and 

  
 PAGE 47 

 
Regulations attached hereto as Exhibit 9-1 and the Construction Rules and Regulations attached hereto as Exhibit
9-2. In the case of any conflict between the provisions of this Lease and any future rules and regulations, the provisions of this Lease shall control. Nothing contained in this Lease shall be construed to
impose upon Landlord any duty or obligation to enforce the Rules and Regulations or the terms, covenants or conditions in any other lease as against any other tenant and Landlord shall not be liable to Tenant for violation of the same by any other
tenant, its servants, employees, agents, contractors, visitors, invitees or licensees. 
 18.2 Energy Conservation. Landlord may
institute upon written notice to Tenant such policies, programs and measures as may be necessary, required, or expedient for the conservation and/or preservation of energy or energy services (collectively, the “Conservation
Program”), provided however: (i) that the Conservation Program does not, by reason of such policies, programs and measures, reduce the level of energy or energy services being provided to the Premises below the level of energy or
energy services then being provided in comparable combination laboratory, research and development and office buildings in the vicinity of the Premises, provided the same shall not come at a material cost to Tenant, or materially adversely affect
Tenant’s use of the Premises for any of the Permitted Uses, or (ii) as may be necessary or required to comply with Legal Requirements or standards or the other provisions of this Lease. Upon receipt of such notice, Tenant
shall comply with the Conservation Program. 
 18.3 Recycling. Upon written notice, Landlord may establish policies, programs and
measures for the recycling of paper, products, plastic, tin and other materials (a “Recycling Program”). Upon receipt of such notice, Tenant will comply with the Recycling Program at Tenant’s sole cost and
expense. 
  

	19.	 LAWS AND PERMITS. 

19.1 Legal Requirements. Tenant shall not cause or permit the Premises, or cause the Property or the Building to be used in any way that
violates any Legal Requirement, order, permit, approval, variance, covenant or restrictions of record or any provisions of this Lease, interferes with the rights of tenants of the Building, or constitutes a nuisance or waste. Tenant shall obtain,
maintain and pay for all permits and approvals needed for the operation of Tenant’s business as soon as reasonably possible, and in any event shall not undertake any operations unless all applicable permits and approvals are in
place and shall, promptly take all actions necessary to comply with all Legal Requirements, including, without limitation, the Occupational Safety and Health Act, applicable to Tenant’s use of the Premises, the Property or the
Building. Tenant shall maintain in full force and effect all certifications or permissions required by any authority having jurisdiction to authorize, franchise or regulate Tenant’s use of the Premises. Tenant shall be solely
responsible for procuring and complying at all times with any and all necessary permits and approvals directly or indirectly relating or incident to: the conduct of its activities on the Premises; its scientific experimentation, transportation,
storage, handling, use and disposal of any chemical or radioactive or bacteriological or pathological substances or organisms or other hazardous wastes or environmentally dangerous substances or materials or medical waste or animals or laboratory
specimens. Within ten (10) days of a request by Landlord, which request shall be made not more than once during each period of twelve (12) consecutive months during the Term hereof, unless otherwise requested by any mortgagee of Landlord
or unless Landlord reasonably suspects that Tenant has violated the provisions of this 

  
 PAGE 48 

 
Section 19.1, Tenant shall furnish Landlord with copies of all such permits and approvals that Tenant possesses or has obtained together with a certificate certifying that such permits are
all of the permits that Tenant possesses or has obtained with respect to the Premises. Tenant shall promptly give written notice to Landlord of any warnings or violations relative to the above received from any federal, state or municipal agency or
by any court of law and shall promptly cure the conditions causing any such violations. Tenant shall not be deemed to be in default of its obligations under the preceding sentence to promptly cure any condition causing any such violation in the
event that, in lieu of such cure, Tenant shall contest the validity of such violation by appellate or other proceedings permitted under applicable law, provided that: (i) any such contest is made reasonably and in good faith, (ii) Tenant
makes provisions, including, without limitation, posting bond(s) or giving other security, reasonably acceptable to Landlord to protect Landlord, the Building and the Property from any liability, costs, damages or expenses arising in connection with
such alleged violation and failure to cure, (iii) Tenant shall agree to indemnify, defend (with counsel reasonably acceptable to Landlord) and hold Landlord harmless from and against any and all liability, costs, damages, or expenses arising in
connection with such condition and/or violation, (iv) Tenant shall promptly cure any violation in the event that its appeal of such violation is overruled or rejected, and (v) Tenant’s decision to delay such cure shall
not, in Landlord’s good faith determination, be likely to result in any actual or threatened bodily injury, property damage, or any civil or criminal liability to Landlord, any tenant or occupant of the Building or the Property,
or any other person or entity. Nothing contained in this Section 19.1 shall be construed to expand the uses permitted hereunder beyond the Permitted Uses. Landlord shall comply with any Legal Requirements and with any direction of any public
office or officer relating to the maintenance or operation of the structural elements of the Building and the Common Areas, and the costs so incurred by Landlord shall be included in Operating Costs in accordance with the provisions of
Section 5.2. 
  

	20.	 DEFAULT 

20.1 Events of Default. The occurrence of any one or more of the following events shall constitute an “Event of
Default” hereunder by Tenant: 
 (a) If Tenant fails to make any payment of Rent or any other payment required hereunder, as and
when due, and such failure shall continue for a period of five (5) days after notice thereof from Landlord to Tenant; provided, however, an Event of Default shall occur hereunder without any obligation of Landlord to give any notice if
(i) Tenant fails to make any payment within five (5) days after the due date therefor, and (ii) Landlord has given Tenant written notice under this Section 20.1(a) on more than two (2) occasions during the twelve
(12) month interval preceding such failure by Tenant; 
 (b) Intentionally omitted. 

(c) If Tenant shall fail to execute and deliver to Landlord an estoppel certificate pursuant to Section 16 above or a subordination and
attornment agreement pursuant to Section 22 below, within the timeframes set forth therein; 
 (d) If Tenant shall fail to maintain any
insurance required hereunder; 

  
 PAGE 49 

 (e) If Tenant shall fail to restore the Security Deposit to its original amount or deliver a
replacement Letter of Credit as required under Section 7 above; 
 (f) If Tenant causes or suffers any release of Hazardous Materials
in or near the Property; 
 (g) If Tenant shall make a Transfer in violation of the provisions of Section 13 above, or if any event
shall occur or any contingency shall arise whereby this Lease, or the term and estate thereby created, would (by operation of law or otherwise) devolve upon or pass to any person, firm or corporation other than Tenant, except as expressly permitted
under Section 13 hereof; 
 (h) Intentionally Omitted; 

(i) The failure by Tenant to observe or perform any of the covenants or provisions of this Lease to be observed or performed by Tenant, other
than as specified above, and such failure continues for more than thirty (30) days after notice thereof from Landlord; provided, further, that if the nature of Tenant’s default is such that more than thirty (30) days are reasonably
required for its cure, then Tenant shall not be deemed to be in default if Tenant shall commence such cure within said thirty (30) day period and thereafter diligently prosecute such cure to completion, which completion shall occur not later
than ninety (90) days from the date of such notice from Landlord; 
 (j) Tenant shall be involved in financial difficulties as
evidenced by an admission in writing by Tenant of Tenant’s inability to pay its debts generally as they become due, or by the making or offering to make a composition of its debts with its creditors; 

(k) Tenant shall make an assignment or trust mortgage, or other conveyance or transfer of like nature, of all or a substantial part of its
property for the benefit of its creditors, 
 (l) an attachment on mesne process, on execution or otherwise, or other legal process shall
issue against Tenant or its property and a sale of any of its assets shall be held thereunder; 
 (m) the leasehold hereby created shall be
taken on execution or by other process of law and shall not be revested in Tenant within thirty (30) days thereafter; 
 (n) a
receiver, sequesterer, trustee or similar officer shall be appointed by a court of competent jurisdiction to take charge of all or any part of Tenant’s Property and such appointment shall not be vacated within thirty (30) days; or 

(o) any proceeding shall be instituted by or against Tenant pursuant to any of the provisions of any Act of Congress or State law relating to
bankruptcy, reorganizations, arrangements, compositions or other relief from creditors, and, in the case of any proceeding instituted against it, if Tenant shall fail to have such proceedings dismissed within thirty (30) days or if Tenant is
adjudged bankrupt or insolvent as a result of any such proceeding. 

  
 PAGE 50 

 With respect to the defaults set forth in subsections (c), (d), (e), (f) and (g) above,
if Tenant shall fail to cure the default within the respective required timeframes set forth in this Lease, and such failure shall continue for three (3) business days after Tenant’s receipt of a Reminder Notice (as defined below), then
such events shall be deemed to be an Event of Default. For purposes hereof, a “Reminder Notice” shall be a notice from Landlord to Tenant that states in bold faced capital letters at the top of the first page thereof the following:
“TENANT’S FAILURE TO CURE DEFAULT WITHIN THREE (3) BUSINESS DAYS AFTER RECEIPT OF THIS NOTICE SHALL CONSTITUTE AN EVENT OF DEFAULT.” 

20.2 Remedies. Upon an Event of Default, Landlord may, by notice to Tenant, elect to terminate this Lease; and thereupon (and without
prejudice to any remedies which might otherwise be available for arrears of Rent or preceding breach of covenant or agreement and without prejudice to Tenant’s liability for damages as hereinafter stated), upon the giving of such notice,
this Lease shall terminate as of the date specified therein as though that were the Expiration Date. Upon such termination, Landlord shall have the right to utilize the Security Deposit or draw down the entire Letter of Credit, as applicable, and
apply the proceeds thereof to its damages hereunder. Without being taken or deemed to be guilty of any manner of trespass or conversion, and without being liable to indictment, prosecution or damages therefor, Landlord may, by lawful process, enter
into and upon the Premises (or any part thereof in the name of the whole); repossess the same, as of its former estate; and expel Tenant and those claiming under Tenant. The words
“re-entry” and “re-enter” as used in this Lease are not restricted to their technical legal
meanings. 
 20.3 Damages - Termination. 

(a) Upon the termination of this Lease under the provisions of this Section 20, Tenant shall pay to Landlord Rent up to the time of such
termination, shall continue to be liable for any preceding breach of covenant, and in addition, shall pay to Landlord as damages, at the election of Landlord, either: 

(i) the amount (discounted to present value at the rate of five percent (5%) per annum) by which, at the time of the
termination of this Lease (or at any time thereafter if Landlord shall have initially elected damages under Section 20.3(a)(ii) below), (x) the aggregate of Rent projected over the period commencing with such termination and ending on the
Expiration Date, exceeds (y) the aggregate projected rental value of the Premises for such period, taking into account a reasonable time period during which the Premises shall be unoccupied, plus all Reletting Costs (hereinafter defined); or

 (ii) amounts equal to Rent which would have been payable by Tenant had this Lease not been so terminated, payable upon the
due dates therefor specified herein following such termination and until the Expiration Date, provided, however, if Landlord shall re-let the Premises during such period, that Landlord shall credit
Tenant with the net rents received by Landlord from such re-letting, such net rents to be determined by first deducting from the gross rents as and when received by Landlord from such re-letting the expenses incurred or paid by Landlord in terminating this Lease, as well as the expenses of re-letting, including altering and preparing the Premises for new
tenants, brokers’ commissions, and all other similar and dissimilar expenses properly 

  
 PAGE 51 

 
chargeable against the Premises and the rental therefrom (collectively, “Reletting Costs”), it being understood that any such re-letting
may be for a period equal to or shorter or longer than the remaining Term; and provided, further, that (x) in no event shall Tenant be entitled to receive any excess of such net rents over the sums payable by Tenant to Landlord hereunder
and (y) in no event shall Tenant be entitled in any suit for the collection of damages pursuant to this Section 20.3(a)(ii) to a credit in respect of any net rents from a re-letting except to the
extent that such net rents are actually received by Landlord prior to the commencement of such suit. If the Premises or any part thereof should be re-let in combination with other space, then proper
apportionment on a square foot area basis shall be made of the rent received from such re-letting and of the expenses of re-letting. 

(b) In calculating the amount due under Section 20.3(a)(i), above, there shall be included, in addition to the Base Rent, all other
considerations agreed to be paid or performed by Tenant, including without limitation Tenant’s Share of Operating Costs and Taxes, on the assumption that all such amounts and considerations would have increased at the rate of three percent (3%)
per annum for the balance of the full term hereby granted. 
 (c) Suit or suits for the recovery of such damages, or any installments
thereof, may be brought by Landlord from time to time at its election, and nothing contained herein shall be deemed to require Landlord to postpone suit until the date when the Term would have expired if it had not been terminated hereunder. 

(d) Nothing herein contained shall be construed as limiting or precluding the recovery by Landlord against Tenant of any sums or damages to
which, in addition to the damages particularly provided above, Landlord may lawfully be entitled by reason of any Event of Default hereunder. 

20.4 Landlord’s Self-Help; Fees and Expenses. If Tenant shall default in the performance of any covenant on Tenant’s part to be performed in this Lease contained, including without limitation the obligation to maintain the Premises in the required condition pursuant to Section 10.1 above, Landlord
may, upon reasonable advance notice, except that no notice shall be required in an emergency, immediately, or at any time thereafter, perform the same for the account of Tenant. Tenant shall pay to Landlord within thirty (30) days of
Landlord’s demand therefor any costs incurred by Landlord in connection therewith, together with interest at the Default Rate until paid in full. In addition, Tenant shall pay all of Landlord’s costs and
expenses, including without limitation reasonable attorneys’ fees, incurred (i) in enforcing any obligation of Tenant under this Lease or (ii) as a result of Landlord or any of the Landlord Parties, without its fault,
being made party to any litigation pending by or against any of the Tenant Parties. 
 20.5 Waiver of Redemption, Statutory Notice and
Grace Periods. Tenant does hereby waive and surrender all rights and privileges which it might have under or by reason of any present or future Legal Requirements to redeem the Premises or to have a continuance of this Lease for the Term hereby
demised after being dispossessed or ejected therefrom by process of law or under the terms of this Lease or after the termination of this Lease as herein provided. Except to the extent prohibited by Legal Requirements, any statutory notice and grace
periods provided to Tenant by law are hereby expressly waived by Tenant. 

  
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 20.6 Landlord’s Remedies Not Exclusive. The specified remedies to which Landlord
may resort hereunder are cumulative and are not intended to be exclusive of any remedies or means of redress to which Landlord may at any time be lawfully entitled, and Landlord may invoke any remedy (including the remedy of specific performance)
allowed at law or in equity as if specific remedies were not herein provided for. 
 20.7 No Waiver. Landlord’s
failure to seek redress for violation, or to insist upon the strict performance, of any covenant or condition of this Lease, or any of the Rules and Regulations promulgated hereunder, shall not prevent a subsequent act, which would have originally
constituted a violation, from having all the force and effect of an original violation. The receipt by Landlord of Rent with knowledge of the breach of any covenant of this Lease shall not be deemed a waiver of such breach. The failure of Landlord
to enforce any of such Rules and Regulations against Tenant and/or any other tenant in the Building shall not be deemed a waiver of any such Rules and Regulations. No provisions of this Lease shall be deemed to have been waived by either party
unless such waiver be in writing signed by such party. No payment by Tenant or receipt by Landlord of a lesser amount than the Rent herein stipulated shall be deemed to be other than on account of the stipulated Rent, nor shall any endorsement or
statement on any check or any letter accompanying any check or payment as Rent be deemed an accord and satisfaction, and Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of
such Rent or pursue any other remedy in this Lease provided. 
 20.8 Restrictions on Tenant’s Rights. During the continuation of
any Event of Default, (a) Landlord shall not be obligated to provide Tenant with any notice pursuant to Sections 2.3 and 2.4 above; and (b) Tenant shall not have the right to make, nor to request Landlord’s consent or
approval with respect to, any Alterations or Transfers. 
 20.9 Landlord Default. Notwithstanding anything to the contrary contained
in the Lease, Landlord shall in no event be in default in the performance of any of Landlord’s obligations under this Lease unless Landlord shall have failed to perform such obligations within thirty (30) days (or such
additional time as is reasonably required to correct any such default, provided Landlord commences cure within 30 days) after notice by Tenant to Landlord properly specifying wherein Landlord has failed to perform any such obligation. Except as
expressly set forth in this Lease, Tenant shall not have the right to terminate or cancel this Lease or to withhold rent or to set-off or deduct any claim or damages against rent as a result of any default by
Landlord or breach by Landlord of its covenants or any warranties or promises hereunder, except in the case of a wrongful eviction of Tenant from the Premises (constructive or actual) by Landlord, and then only if the same continues after notice to
Landlord thereof and an opportunity for Landlord to cure the same as set forth above. In addition, Tenant shall not assert any right to deduct the cost of repairs or any monetary claim against Landlord from rent thereafter due and payable under this
Lease. 

  
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	21.	 SURRENDER; ABANDONED PROPERTY; HOLD-OVER 

21.1 Surrender 
 (a) Upon
the expiration or earlier termination of the Term, Tenant shall (i) peaceably quit and surrender to Landlord the Premises (including without limitation all fixed lab benches, fume hoods, electric, plumbing, heating and sprinkling systems,
fixtures and outlets, vaults, paneling, molding, shelving, radiator enclosures, cork, rubber, linoleum and composition floors, ventilating, silencing, air conditioning and cooling equipment therein and all other furniture, fixtures, and equipment
that was either provided by Landlord or paid for in whole or in part by any allowance provided to Tenant by Landlord under this Lease) broom clean, in good order, repair and condition excepting only ordinary wear and tear and damage by fire or other
insured Casualty; (ii) remove all of Tenant’s Property, all autoclaves and cage washers and, at Landlord’s election, any Alterations made by Tenant (Landlord hereby agreeing to make such election at the time that Landlord approves any
Alteration if so requested by Tenant in writing at the time that Tenant requests that Landlord approve the plans and specifications for such Alteration); and (iii) repair any damages to the Premises or the Building caused by the installation or
removal of Tenant’s Property and/or such Alterations. Tenant’s obligations under this Section 21.1(a) shall survive the expiration or earlier termination of this Lease. Notwithstanding anything to the contrary in the Lease contained,
the parties expressly agree that Tenant shall have the right, on or before the expiration or prior termination of the term of the Lease, to remove those items of equipment and fixtures which are described on Exhibit 13 hereto, provided that
Tenant repairs any damage to the Premises and/or the Building caused by the installation or removal of such items. 
 (b) Prior to the
expiration of this Lease (or within thirty (30) days after any earlier termination), Tenant shall clean and otherwise decommission all interior surfaces (including floors, walls, ceilings, and counters), piping, supply lines, waste lines, acid
neutralization systems and plumbing in and/or exclusively serving the Premises, and all exhaust or other ductwork in and/or exclusively serving the Premises, in each case which has carried or released or been contacted by any Hazardous Materials or
other chemical or biological materials used in the operation of the Premises, and shall otherwise clean the Premises so as to permit the Surrender Plan (defined below) to be issued. At least thirty (30) days prior to the expiration of the Term
(or, if applicable, within five (5) business days after any earlier termination of this Lease), Tenant shall deliver to Landlord a reasonably detailed narrative description of the actions proposed (or required by any Legal Requirements) to be
taken by Tenant in order to render the Premises (including any Alterations permitted or required by Landlord to remain therein) free of Hazardous Materials and otherwise released for unrestricted use and occupancy including without limitation
causing the Premises to be decommissioned in accordance with the regulations of the U.S. Nuclear Regulatory Commission and/or the Massachusetts Department of Public health (the “MDPH”) for the control of radiation, and cause the
Premises to be released for unrestricted use by the Radiation Control Program of the MDPH (the “Surrender Plan”). The Surrender Plan (i) shall be accompanied by a current list of (A) all Required Permits held by or on
behalf of any Tenant Party with respect to Hazardous Materials in, on, under, at or about the Premises, and (B) Tenant’s Hazardous Materials, and (ii) shall be subject to the review and approval of Landlord’s environmental
consultant. In connection with review and approval of the Surrender Plan, upon request of Landlord, Tenant shall deliver to Landlord or its consultant such additional non-proprietary information concerning the
use of and operations within the Premises as Landlord shall request. On or before the expiration of the Term (or within thirty (30) days after any earlier termination of this Lease, during which period Tenant’s use and occupancy of the
Premises shall be governed by Section 21.3 below), Tenant shall (i) perform or cause to be 

  
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performed all actions described in the approved Surrender Plan, and (ii) deliver to Landlord a certification from a third party certified industrial hygienist reasonably acceptable to
Landlord certifying that the Premises do not contain any Hazardous Materials and evidence that the approved Surrender Plan shall have been satisfactorily completed by a contractor acceptable to Landlord, and Landlord shall have the right, subject to
reimbursement at Tenant’s expense as set forth below, to cause Landlord’s environmental consultant to inspect the Premises and perform such additional procedures as may be deemed reasonably necessary to confirm that the Premises are, as of
the expiration of the Term (or, if applicable, the date which is thirty (30) days after any earlier termination of this Lease), free of Hazardous Materials and otherwise available for unrestricted use and occupancy as aforesaid. Landlord shall
have the unrestricted right to deliver the Surrender Plan and any report by Landlord’s environmental consultant with respect to the surrender of the Premises to third parties. Such third parties and the Landlord Parties shall be entitled to
rely on the Surrender Report. If Tenant shall fail to prepare or submit a Surrender Plan approved by Landlord, or if Tenant shall fail to complete the approved Surrender Plan, or if such Surrender Plan, whether or not approved by Landlord, shall
fail to adequately address the use of Hazardous Materials by any of the Tenant Parties in, on, at, under or about the Premises, Landlord shall have the right to take any such actions as Landlord may deem reasonable or appropriate to assure that the
Premises and the Property are surrendered in the condition required hereunder, the cost of which actions shall be reimbursed by Tenant as Additional Rent within thirty (30) days of Landlord’s written demand. Tenant’s obligations under
this Section 21.1(b) shall survive the expiration or earlier termination of the Term. 
 (c) No act or thing done by Landlord during
the Term shall be deemed an acceptance of a surrender of the Premises, and no agreement to accept such surrender shall be valid, unless in writing signed by Landlord. Unless otherwise agreed by the parties in writing, no employee of Landlord or of
Landlord’s agents shall have any power to accept the keys of the Premises prior to the expiration or earlier termination of this Lease. The delivery of keys to any employee of Landlord or of Landlord’s agents shall not operate as a
termination of this Lease or a surrender of the Premises. 
 (d) Notwithstanding anything to the contrary contained herein, Tenant shall, at
its sole cost and expense, remove from the Premises, prior to the end of the Term, any item installed by or for Tenant and which, pursuant to Legal Requirements, must be removed therefrom before the Premises may be used by a subsequent tenant. 

21.2 Abandoned Property. After the expiration or earlier termination hereof, if Tenant fails to remove any property from the Building
or the Premises which Tenant is obligated by the terms of this Lease to remove within five (5) business days after written notice from Landlord, such property (the “Abandoned Property”) shall be conclusively deemed to have been
abandoned, and may either be retained by Landlord as its property or sold or otherwise disposed of in such manner as Landlord may see fit. If any item of Abandoned Property shall be sold, Tenant hereby agrees that Landlord may receive and retain the
proceeds of such sale and apply the same, at its option, to the expenses of the sale, the cost of moving and storage, any damages to which Landlord may be entitled under Section 20 hereof or pursuant to law, and to any arrears of Rent. 

  
 PAGE 55 

 21.3 Holdover. If any of the Tenant Parties holds over (which term shall include,
without limitation, the failure of Tenant or any Tenant Party to perform all of its obligations under Section 21.1 above) after the end of the Term, Tenant shall be deemed a
tenant-at-sufferance subject to the provisions of this Lease. Whether or not Landlord has previously accepted payments of Rent from Tenant: 

(i) Tenant shall pay Base Rent at the Hold Over Percentage, as hereinafter defined, of the highest rate of Base Rent payable
during the Term, 
 (ii) Tenant shall continue to pay to Landlord all Additional Rent, and 

(iii) in the event such hold over extends beyond sixty (60) days after the end of the Term, Tenant shall be liable for all
damages, including without limitation lost business and consequential damages, incurred by Landlord as a result of such holding over, Tenant hereby acknowledging that Landlord may need the Premises after the end of the Term for other tenants and
that the damages which Landlord may suffer as the result of Tenant’s holding over cannot be determined as of the Execution Date. Nothing contained herein shall grant Tenant the right to holdover after the expiration or earlier termination of
the Term. The “Hold Over Percentage” shall be 150% for the first sixty (60) days of such holdover, and 200% for any period of hold over after the first sixty (60) days. Nothing contained herein shall grant Tenant the right
to holdover after the expiration or earlier termination of the Term. 
 21.4 Warranties. Tenant hereby assigns to Landlord any
warranties in effect on the last day of the Term with respect to any fixtures and Alterations installed in the Premises. Tenant shall provide Landlord with copies of any such warranties prior to the expiration of the Term (or, if the Lease is
earlier terminated, within five (5) days thereafter). 
  

	22.	 MORTGAGEE RIGHTS 

22.1 Subordination. Tenant’s rights and interests under this Lease shall be (i) subject and subordinate to any ground
lease, overleases, mortgage, deed of trust, or similar instrument covering the Premises, the Building and/or the Land and to all advances, modifications, renewals, replacements, and extensions thereof (each of the foregoing, a
“Mortgage”), or (ii) if any Mortgagee elects, prior to the lien of any present or future Mortgage. Tenant further shall attorn to and recognize any successor landlord, whether through foreclosure or otherwise, as if the
successor landlord were the originally named landlord. The provisions of this Section 22.1 shall be self-operative and no further instrument shall be required to effect such subordination or attornment; however, Tenant agrees to execute,
acknowledge and deliver such instruments, confirming such subordination and attornment in such form as shall be requested by any such holder within fifteen (15) days of request therefor. Such instruments shall be on the customary form used by
such holder with such commercially reasonable changes as may be requested by Tenant. 

  
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 Notwithstanding the foregoing, it shall be a condition to Tenant’s obligation to
subordinate the Lease to any future Mortgage that the holder of such future Mortgage enters into an SNDA with Tenant. An “SNDA” shall be defined as a subordination, non-disturbance and
attornment agreement on the standard form of SNDA then being used by the holder of the Mortgage in question, with such commercially reasonable modifications as may be requested by Tenant. Tenant shall pay any reasonable charges (including legal
fees) required by such holder as a condition to entering into such SNDA. 
 22.2 Notices. Tenant shall give each Mortgagee the same
notices given to Landlord concurrently with the notice to Landlord, and each Mortgagee shall have a reasonable opportunity thereafter to cure a Landlord default, and Mortgagee’s curing of any of Landlord’s
default shall be treated as performance by Landlord. 
 22.3 Mortgagee Consent. Tenant acknowledges that, where applicable, any
consent or approval hereafter given by Landlord may be subject to the further consent or approval of a Mortgagee; and the failure or refusal of such Mortgagee to give such consent or approval shall, notwithstanding anything to the contrary in this
Lease contained, constitute reasonable justification for Landlord’s withholding its consent or approval. 
 22.4
Mortgagee Liability. Tenant acknowledges and agrees that if any Mortgage shall be foreclosed, (a) the liability of the Mortgagee and its successors and assigns shall exist only so long as such Mortgagee or purchaser is the owner of the
Premises, and such liability shall not continue or survive after further transfer of ownership; and (b) subject to the last sentence of this Section 22.4, such Mortgagee and its successors or assigns shall not be (i) liable for any
act or omission of any prior lessor under this Lease; (ii) liable for the performance of Landlord’s covenants pursuant to the provisions of this Lease which arise and accrue prior to such entity succeeding to the interest of
Landlord under this Lease or acquiring such right to possession; (iii) subject to any offsets or defense which Tenant may have at any time against Landlord; (iv) bound by any base rent or other sum which Tenant may have paid previously for
more than one (1) month; or (v) liable for the performance of any covenant of Landlord under this Lease which is capable of performance only by the original Landlord. Notwithstanding the foregoing: (x) nothing shall relieve any
Mortgagee, purchaser at foreclosure, or grantee of a deed in lieu of foreclosure from: (i) any liability which it has party-Landlord from and after the date which it succeeds to Landlord’s interest under the Lease, and
(y) any obligation which Landlord has to perform repairs or maintenance under the Lease based upon the fact that the need for such repairs or maintenance first arose after the Succession Date. 

 

	23.	 QUIET ENJOYMENT. 

Landlord covenants that so long as Tenant keeps and performs each and every covenant, agreement, term, provision and condition herein contained
on the part and on behalf of Tenant to be kept and performed, Tenant shall peaceably and quietly hold, occupy and enjoy the Premises during the Term from and against the claims of all persons lawfully claiming by, through or under Landlord subject,
nevertheless, to the covenants, agreements, terms, provisions and conditions of this Lease, any matters of record or of which Tenant has knowledge and to any Mortgage to which this Lease is subject and subordinate, as hereinabove set forth. 

  
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	24.	 NOTICES. 

Any notice, consent, request, bill, demand or statement hereunder (each, a “Notice”) by either party to the other party shall
be in writing and shall be deemed to have been duly given when either delivered by hand or by nationally recognized overnight courier (in either case with evidence of delivery or refusal thereof) addressed as follows: 

 

			
	 If to Landlord:
	  	 HCP/King Hayden Campus LLC

c/o King Street Properties

800 Boylston Street, Floor 15

Boston, MA 02199

Attention: Stephen D. Lynch

		
	 With a copy to:
	  	 Goulston & Storrs PC

400 Atlantic Avenue

Boston, MA 02110

Attention: King Street

		
	 If to Tenant:
	  	 Kaleido Biosciences, Inc.

65 Hayden Avenue

Lexington, MA 02421

Attention: Chief Financial Officer

		
	 With a copy to:
	  	 Goodwin Procter LLP

100 Northern Avenue

Boston, MA 02210

Attention: Nicole W. Riley, Esq.

 Notwithstanding the foregoing, any notice from Landlord to Tenant regarding ordinary business operations (e.g., exercise of a
right of access to the Premises, maintenance activities, invoices, etc.) may also be given by written notice delivered by email to those parties listed in Section 2.4. Either party may at any time change the address or specify an additional
address for such Notices by delivering or mailing, as aforesaid, to the other party a notice stating the change and setting forth the changed or additional address, provided such changed or additional address is within the United States. Notices
shall be effective upon the date of receipt or refusal thereof. 
  

	25.	 MISCELLANEOUS 

25.1 Separability. If any provision of this Lease or portion of such provision or the application thereof to any person or circumstance
is for any reason held invalid or unenforceable, the remainder of this Lease (or the remainder of such provision) and the application thereof to other persons or circumstances shall not be affected thereby. 

25.2 Captions. The captions are inserted only as a matter of convenience and for reference, and in no way define, limit or describe the
scope of this Lease nor the intent of any provisions thereof. 

  
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 25.3 Broker. Tenant and Landlord each warrants and represents that it has dealt with
no broker in connection with the consummation of this Lease other than Newmark Knight Frank and Jones Lang LaSalle (collectively, “Broker”). Tenant and Landlord each agrees to defend, indemnify and save the other harmless from and
against any Claims arising in breach of the representation and warranty set forth in the immediately preceding sentence. Landlord shall be solely responsible for the payment of any brokerage commissions to Broker. 

25.4 Entire Agreement. This Lease, Lease Summary Sheet and Exhibits 1-13 attached hereto
and incorporated herein contain the entire and only agreement between the parties and any and all statements and representations, written and oral, including previous correspondence and agreements between the parties hereto, are merged herein.
Tenant acknowledges that all representations and statements upon which it relied in executing this Lease are contained herein and that Tenant in no way relied upon any other statements or representations, written or oral. This Lease may not be
modified orally or in any manner other than by written agreement signed by the parties hereto. 
 25.5 Governing Law. This Lease is
made pursuant to, and shall be governed by, and construed in accordance with, the laws of the Commonwealth of Massachusetts and any applicable local municipal rules, regulations, by-laws, ordinances and the
like. 
 25.6 Representation of Authority. By his or her execution hereof, each of the signatories on behalf of the respective
parties hereby warrants and represents to the other that he or she is duly authorized to execute this Lease on behalf of such party. Upon Landlord’s request, Tenant shall provide Landlord with evidence that any requisite resolution,
corporate authority and any other necessary consents have been duly adopted and obtained. 
 25.7 Expenses Incurred by Landlord. 

 (a) Tenant shall, upon demand, reimburse Landlord for all reasonable expenses, including, without limitation, legal fees, incurred by
Landlord in connection with all requests by Tenant for consents, approvals or execution of collateral documentation related to this Lease, including, without limitation, costs incurred by Landlord in the review and approval of Tenant’s plans
and specifications in connection with proposed Alterations to be made by Tenant to the Premises or in connection with requests by Tenant for Landlord’s consent to make a Transfer. Such costs shall be deemed to be Additional Rent under this
Lease. 
 Notwithstanding the foregoing: (i) the amount of legal fees which Tenant is required to reimburse Landlord with respect to
any Transfer shall not exceed the Transfer Legal Fee Cap, as hereinafter defined, with respect to such Transfer, and (ii) with respect any request by Tenant to review and approve Tenant’s plans and specifications with respect to any
Alteration, Tenant shall only be required to reimburse Landlord for third party consultants engaged by Landlord to review such plans and specifications as Landlord, in good faith determines is necessary (e.g., reviews by structure engineers, MEP
engineers, etc.). The “Transfer Legal Fees Cap” shall be defined as $2,500.00, except that (a) the Transfer Legal Fees Cap shall increase by $500 every fifth (5th) anniversary of the North Premises Base Rent Commencement Date,
and (b) the Transfer Legal Fees Cap shall not apply to Tenant’s request for Landlord’s approval of any sub-sublease of any tier. 

  
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 (b) In the case of litigation or other legal proceeding between Landlord and Tenant relating
to the provisions of this Lease or Tenant’s occupancy of the Premises, the losing party shall, upon demand, reimburse the prevailing party for its reasonable costs of prosecuting and/or defending such proceeding (including, without limitation,
reasonable attorneys’ fees). 
 25.8 Survival. Without limiting any other obligation of Tenant which may survive the expiration
or prior termination of the Term, all obligations on the part of Tenant to indemnify, defend, or hold Landlord harmless, as set forth in this Lease shall survive the expiration or prior termination of the Term. 

25.9 Limitation of Liability. 

(a) Limitation on Landlord’s Liability. Tenant shall neither assert nor seek to enforce any claim against Landlord or any of the
Landlord Parties, or the assets of any of the Landlord Parties, for breach of this Lease or otherwise, other than against Landlord’s interest in the Building and in the uncollected rents, issues and profits thereof, and Tenant agrees to look
solely to such interest for the satisfaction of any liability of Landlord under this Lease. This Section 25.9(a) shall not limit any right that Tenant might otherwise have to obtain injunctive relief against Landlord. Landlord and Tenant
specifically agree that in no event shall any officer, director, trustee, employee or representative of Landlord or any of the other Landlord Parties ever be personally liable for any obligation under this Lease, nor shall Landlord or any of the
other Landlord Parties be liable for consequential or incidental damages or for lost profits whatsoever in connection with this Lease. 

(b) Limitation on Tenant’s Liability. Landlord shall neither assert nor seek to enforce any claim against Tenant or any of the
Tenant Parties for breach of this Lease or otherwise, other than against the assets and property of Tenant, and Landlord agrees to look solely to such assets and property for the satisfaction of any liability of Tenant or any Tenant Parties under
this Lease. This Section 25.9(b) shall not limit any right that Landlord might otherwise have to obtain injunctive relief against Tenant. Landlord and Tenant specifically agree that in no event: (i) any officer, director,
trustee, employee or representative of Tenant or any of the other Tenant Parties ever be personally liable for any obligation under this Lease, and (ii) Tenant or any of the other Tenant Parties be liable for consequential or
incidental damages or for lost profits whatsoever in connection with this Lease, except that nothing in this Section 25.9(b) shall limit or affect any liability or obligation which Tenant may have in the event of any breach by
Tenant of its obligations under either Section 17 (Hazardous Materials) or Section 21.3 (Holdover). 

25.10 Binding Effect. The covenants, agreements, terms, provisions and conditions of this Lease shall bind and benefit the successors
and assigns of the parties hereto with the same effect as if mentioned in each instance where a party hereto is named or referred to, except that no violation of the provisions of Section 13 hereof shall operate to vest any rights in any
successor or assignee of Tenant. 

  
 PAGE 60 

 25.11 Landlord Obligations upon Transfer. Upon any sale, transfer or other
disposition of the Building, Landlord shall be entirely freed and relieved from the performance and observance thereafter of all covenants and obligations hereunder on the part of Landlord to be performed and observed, it being understood and agreed
in such event (and it shall be deemed and construed as a covenant running with the land) that the person succeeding to Landlord’s ownership of said reversionary interest shall thereupon and thereafter assume, and perform and observe, any
and all of such covenants and obligations of Landlord, except as otherwise agreed in writing. 
 25.12 No Grant of Interest. Tenant
shall not grant any interest whatsoever in any fixtures within the Premises or any item paid in whole or in part by Landlord’s Contribution or by Landlord. 

25.13 Financial Information. Tenant shall deliver to Landlord, within thirty (30) days after Landlord’s reasonable
request (which request may be made no more often than one time every twelve (12) month period), Tenant’s most recently completed balance sheet and related statements of income, shareholder’s equity and cash flows
statements (audited if available) reviewed by an independent certified public accountant and certified by an officer of Tenant as being true and correct in all material respects. Any such financial information may be relied upon by any actual or
potential lessor, purchaser, or mortgagee of the Property or any portion thereof. 
 25.14 OFAC Certificate and Indemnity. Executive
Order No. 13224 on Terrorist Financing, effective September 24, 2001 (the “Executive Order”), and the Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act of
2001 (Public Law 10756, the “Patriot Act”) prohibit certain property transfers. Tenant hereby represents and warrants to Landlord (which representations and warranties shall be deemed to be continuing and re-made at all times during the Term) that neither Tenant nor to Tenant’s knowledge any stockholder, manager, beneficiary, partner, or principal of Tenant is subject to the Executive Order, that none of
them is listed on the United States Department of the Treasury Office of Foreign Assets Control (“OFAC”) list of “Specially Designated Nationals and Blocked Persons” as modified from time to time, and that
none of them is otherwise subject to the provisions of the Executive Order or the Patriot Act. The most current list of “Specially Designated Nationals and Blocked Persons” can be found at
http://www.treas.gov/offices/eotffc/ofac/sdn/index.html. Tenant shall from time to time, within ten days after request by Landlord, deliver to Landlord any certification or other evidence requested from time to time by Landlord in its reasonable
discretion, confirming Tenant’s compliance with these provisions. No assignment or subletting shall be effective unless and until the assignee or subtenant thereunder delivers to Landlord written confirmation of such party’s
compliance with the provisions of this subsection, in form and content satisfactory to Landlord. If for any reason the representations and warranties set forth in this subsection, or any certificate or other evidence of compliance delivered to
Landlord hereunder, is untrue in any respect when made or delivered, or thereafter becomes untrue in any respect, then an Event of Default hereunder shall be deemed to occur immediately, and there shall be no opportunity to cure. Tenant shall
indemnify, defend with counsel reasonably acceptable to Landlord, and hold Landlord harmless from and against, any and all liabilities, losses claims, damages, penalties, fines, and costs (including attorneys’ fees and costs) arising
from or related to the breach of any of the foregoing representations, warranties, and duties of Tenant. The provisions of this subsection shall survive the expiration or earlier termination of this Lease for the longest period permitted by law.

  
 PAGE 61 

 25.15 Confidentiality. Tenant acknowledges and agrees that the terms of this Lease
are confidential. Disclosure of the terms hereof could adversely affect the ability of Landlord to negotiate other leases with respect to the Building and may impair Landlord’s relationship with other tenants of the Building. Tenant
shall not disclose the terms and conditions of this Lease to any other person or entity without the prior written consent of Landlord, which may be given or withheld by Landlord, in Landlord’s sole discretion, except as required for
financial disclosures or securities filings, as required by the order of any court or public body with authority over Tenant, or in connection with any litigation between Landlord and Tenant with respect to this Lease or to Tenant’s
partners, officers, directors, employees, brokers, attorneys, or as may be required as part of any financing or Tenant’s normal course of business. It is understood and agreed that damages alone would be an inadequate remedy for the
breach of this provision by Tenant, and Landlord shall also have the right to seek specific performance of this provision and to seek injunctive relief to prevent its breach or continued breach. 

25.16 Force Majeure. Other than for Tenant’s obligations under this Lease that can be performed by the payment of money
(e.g., payment of Rent and maintenance of insurance), whenever a period of time is herein prescribed for action to be taken by either party hereto, such party shall not be liable or responsible for, and there shall be excluded from the computation
of any such period of time, any delays due to strikes, riots, acts of God, shortages of labor or materials, war, acts of terrorism, governmental laws, regulations, or restrictions, or any other causes of any kind whatsoever which are beyond the
control of such party (collectively “Force Majeure”). In no event shall financial inability of a party be deemed to be Force Majeure. 

  
 PAGE 62 

 IN WITNESS WHEREOF the parties hereto have executed this Lease as a sealed instrument as of
the Execution Date. 
  

							
	LANDLORD
	
	HCP/KING HAYDEN CAMPUS LLC,
	a Delaware limited liability company
		
	By:	 	King Mattingly LLC, a Massachusetts
limited liability company, its Manager
			
		 	By:	 	King Street Properties Investments
		 		 	LLC, a Massachusetts limited liability
		 		 	company, its Manager
				
		 		 	By:	 	/s/ Stephan D. Lynch
		 		 		 	Name: Stephan D. Lynch
		 		 		 	Its Manager

  

					
	TENANT
	
	KALEIDO BIOSCIENCES, INC.,
	a Delaware corporation
		
	By:	 	/s/ Michael W. Bonney
		 	Name:	 	Michael W. Bonney
		 	Title:	 	Chief Executive Officer & Chair

  
 PAGE 63 

 EXHIBIT 1A 

LEASE PLAN – PRIME PREMISES 
  

 

  
 EXHIBIT 1A, PAGE 1 

 EXHIBIT 1B 

LEASE PLAN – PH SYSTEM PREMISES 
  

 

  
 EXHIBIT 1B, PAGE 1 

 EXHIBIT 1C 

LEASE PLAN – EXPANSION PREMISES 
  

 

  
 EXHIBIT 1C, PAGE 1 

 EXHIBIT 1C-A 

LEASE PLAN – EXPANSION PREMISES A 
  

 

  
 EXHIBIT 1C-A, PAGE 1 

 EXHIBIT 1C-B 

LEASE PLAN – EXPANSION PREMISES B 
  

 

  
 EXHIBIT 1C-B, PAGE 1 

 EXHIBIT 2 

LEGAL DESCRIPTION—LAND 
 Real property
in the Town of Lexington, County of Middlesex, Commonwealth of Massachusetts, described as follows: 
 Parcel One (45 & 55 Hayden Avenue):

 A certain parcel of land in the Commonwealth of Massachusetts, County of Middlesex, Town of Lexington, and shown as Lot 2 on a plan entitled “Plan
of Land in Lexington, Mass. (Middlesex County),” dated March 27, 1998, recorded October 6, 1998, with Middlesex South Registry of Deeds as Plan No. 1088 of 1998 in Book 29190, Page 447, prepared by Beals and Thomas, Inc., more
particularly bounded and described as follows: 
 Beginning at the most southwesterly corner of the premises, at the southeasterly corner of Lot 1 as shown
on said plan, then running: 
 N 02° 20’ 56” E 180.68 feet to a point, thence turning and running; 

N 87° 39” 04” W 40.00 feet to a point, thence turning and running; 

N 02° 20’ 56” E 122.19 feet to a point, thence turning and running; 

N 87° 39’ 04” E 40.00 feet to a point, thence turning and running; 

N 02° 20’ 56” E 547.13 feet to a point, thence turning and running, said last five courses being bounded by Lot 1, as shown on said plan, thence
turning and running; 
 S 87° 36’ 20” E 1,330.04 feet to a point of curvature, thence running; 

Northeasterly to a curve to the left having a radius of 135.00 feet and a length of 58.90 feet to a point of tangency, thence running; 

N 67° 23’ 52” E 146.89 feet to a point, thence turning and running; 

S 03° 52’ 06” E 111.25 feet to a point, said last four courses being bounded by land now or formerly of the Town of Lexington, thence turning
and running; 
 S 44° 07’ 54 W 561.19 feet to a point, thence turning and running; 

S 22° 29’ 38” E 435.76 feet to a point, said last two courses are bounded in part by land now or formerly the Town of Lexington and, in part now
or formerly of Hayden Office Trust, thence running; 
 Southwesterly by a curve to the right, having a radius of 985.00 feet and a length of 12.11 feet to a
point of tangency, thence turning and running; 
 N 87° 36’ 20” W 1,329.27 feet to the point of beginning, said last two courses being bounded
by the northerly sideline of Hayden Avenue. 

  
 EXHIBIT 2, PAGE 1 

 Containing 1,123,722 square feet more or less, or 25.797 acres, more or less. 

A portion of said Lot 2 is registered land, described as follows: 

Lot 293 on Land Court Plan 19485 N as approved by the Land Court and filed in the Land Registration Office; and 

Lots 10 and 11 on Land Court Plan 16660 O as approved by the Land Court and filed with the Land Registration Office. 

Parcel Two (Appurtenant Easements - 45 & 55 Hayden Avenue): 
  

	A.	 There is appurtenant to the above described Lot 11 the right and easement to use the drainage ditch running
from west to east across the northerly portion of Lot 10, shown on said plan, as set forth in Registered Document No. 517903. 

  

	B.	 There is appurtenant to the above described Lot 11 rights and easements for sewer purposes as set forth in
Registered Document No. 479201. 

  

	C.	 There is appurtenant to said Lot 293 the benefits of the agreement and reservation as to trunk sewer more
particularly set forth in deed filed as Document No. 479738. 

  

	D.	 Lot 10 has the benefit of a reservation in the strip of land marked sewer easement as shown on said plan, set
forth in Document 517903 and the rights and easements for sewer purposes as set forth in Registered Document No. 479201, insofar as applicable. 

  

	E.	 Together with the benefit of the appurtenant easements over Lot B shown on plan entitled “A Compiled Plan
of Land in Lexington, Mass.” Dated August 27, 1970, by John J. McSweeney, recorded with Middlesex South District Deeds in Book 11928, Page 614, as shown on said plan, as reserved in a taking by the Town of Lexington dated November 30,
1970, recorded with said Deeds in Book 11928, Page 611, and in a deed from George H. Crawford to the Town of Lexington of the said Lot B dated December 7, 1970, recorded with said Deeds in Book 11928, Page 614. 

 

	F.	 Together with the benefit of the appurtenant easements set forth in Declaration of Covenants and Easements
dated September 18, 1998 filed as Document No. 1084070 and recorded in Book 29287, Page 189; as affected by Amended and Restated Declaration of Covenants and Easements dated November 8, 1999, filed as Document No. 1123738, and
recorded in Book 30855, Page 323; as affected by First Amendment to Amended and Restated Declaration of Covenants and Easements dated March 26, 2002, filed as Document No. 1261521, recorded in Book 37256, Page 364. 

Parcel Three (65 Hayden Avenue): 
 That certain
parcel of land situate in Lexington in the County of Middlesex and Commonwealth of Massachusetts shown as Lot 292 on Land Court Plan No. 19485-N. 

All of said boundaries are determined by the Court to be located as shown on a subdivision plan, as approved by the Court, filed in the Land Registration
Office, a copy of which is filed in the Registry of Deeds for the South Registry District of Middlesex County in Registration Book 1178 Page 11. 

  
 EXHIBIT 2, PAGE 2 

 Parcel Four (Appurtenant Easements—65 Hayden Avenue): 

There is appurtenant to said Lot 292 the right to use the whole of Grassland Street and Valleyfield Street as shown on the plan Registered in the Registration
Book 383 Page 149 in common with others entitled thereto; the right to use all streets or roads as shown on the plan Registered in Registration Book 506 Page 153, in common with all others legally entitled thereto; the benefit of the agreement and
reservation as to trunk sewer more particularly set forth in the deed Registered as Document No. 479738; and the benefit of the appurtenant easements set forth in Declaration of Covenants and Easements dated September 18, 1998 filed as
Document No. 1084070 and recorded in Book 29287, Page 189; as affected by Amended and Restated Declaration of Covenants and Easements dated November 8, 1999, filed as Document No. 1123738, and recorded in Book 30855, Page 323; as
affected by First Amendment to Amended and Restated Declaration of Covenants and Easements dated March 26, 2002, filed as Document No. 1261521, recorded in Book 37256, Page 364 

  
 EXHIBIT 2, PAGE 3 

 EXHIBIT 3, SHEET 1 

PLAN – CURRENT PARKING AREAS 
  

 

  
 EXHIBIT 3, SHEET 1 

 EXHIBIT 3, SHEET 2 

PLAN—CURRENT PARKING AREAS 
  

 

  
 EXHIBIT 3, SHEET 2 

 EXHIBIT 4 

WORK LETTER 
 This Exhibit
is attached to and made a part of the Lease (the “Lease”) by and between HCP/KING HAYDEN CAMPUS LLC, a Delaware limited liability company (“Landlord”), and KALEIDO BIOSCIENCES, INC., a Delaware
corporation (“Tenant”), for space located at 65 Hayden Avenue, Lexington, Massachusetts. Capitalized terms used but not defined herein shall have the meanings given in the Lease. 

This Work Letter shall set forth the obligations of Landlord and Tenant with respect to the improvements to be performed in preparing the
Premises for Tenant’s use. This Exhibit shall not be deemed applicable to any additional space added to the Premises at any time or from time to time, whether by any options under the Lease or otherwise, or to any portion of the original
Premises or any additions to the Premises in the event of a renewal or extension of the original Term of the Lease, whether by any options under the Lease or otherwise, unless expressly so provided in the Lease or any amendment or supplement to the
Lease. 
  

	I.	 North Premises. 

1. Definitions. Tenant acknowledges and agrees that Tenant is leasing the North Premises in their “AS IS,”
“WHERE IS” condition and with all faults on the Execution Date, without representations or warranties, express or implied, in fact or by law, of any kind, and without recourse to Landlord, except that Landlord shall perform
Landlord’s North Premises Work, as hereinafter defined, in accordance with the provisions of Section 3 of the Lease, this Section I, Exhibit 4, and Landlord shall provide Landlord’s North Premises Contribution, as hereinafter
defined, to Tenant in accordance with Section 11 of this Section I, Exhibit 4. Section I of this Work Letter sets forth the obligations of Landlord with respect to the improvements to be performed in the North Premises by Landlord
(“Landlord’s North Premises Work”). The parties intend that Landlord’s Work will be in accordance with construction documents (the “North Premises Construction
Documents”) prepared by Landlord and approved by Tenant in accordance with this Exhibit 4, and the North Premises Construction Documents will be based upon the schematic plan (“Initial Plan for North
Premises”) attached hereto as Exhibit 4-1 and the equipment list (“Equipment Utility Matrix for North Premises”) attached hereto as Exhibit 4-2, and the Architectural Basis of Design set forth in Exhibit 4-3. Landlord and Tenant acknowledge that the North Premises Construction Documents have not yet
been prepared and, therefore, it is impossible to determine the exact cost of the Landlord’s North Premises Work at this time. Accordingly, Landlord and Tenant agree that Landlord’s obligation to pay for the Cost of Landlord’s North
Premises Work, as hereinafter defined, shall be limited to an amount (“Landlord’s North Premises Contribution”) which shall not exceed $3,548,700.00 (i.e., $90.00 per rentable square foot of the North Premises
(the “North Premises Maximum Amount”) and that Tenant shall be responsible for the Cost of Landlord’s North Premises Work to the extent that it exceeds the North Premises Maximum Amount. The
“Cost of Landlord’s North Premises Work” shall be defined as all hard costs (“North Premises Hard Costs”) incurred by Landlord relating to the performance of the
Landlord’s North Premises Work (including, without limitation, the cost of obtaining permits and any applicable state sales and use taxes) and soft costs (“North Premises Soft Costs”) incurred by Landlord
in connection 

  
 EXHIBIT 4, PAGE 1 

 
with Landlord’s North Premises Work (including, without limitation, the cost of preparing the North Premises Construction Documents). “North Premises Other Permitted Costs”
shall be defined as costs incurred by Tenant in project management fees and in installing data/telecom cabling in the North Premises. The North Premises Hard Costs, North Premises Soft Costs, and North Premises Other Permitted Costs are referred to
collectively herein as the “North Premises Permitted Costs”. Not more than $354,870.00 of Landlord’s North Premises Contribution may be applied towards the North Premises Soft Costs and the North Premises Other Permitted Costs.
Landlord will charge Tenant a construction management fee equal to 3% of the amount of the North Premises Hard Costs and the North Premises Soft Costs incurred by Landlord in connection with the Landlord’s North Premises Work. 

2. Contractor; GMP. Landlord shall enter into a contract (“Contract”) for the Landlord’s North Premises Work with
BW Kennedy (“Contractor”). The Contract may be on the basis of a guaranteed maximum price (“GMP”). The GMP shall be determined based upon the sum of the following: 

 

	 	•	 	 Design-Builder’s Fee: 3% of the sum (the “Cost of Landlord’s North Premises
Work”) of: (i) the Direct Cost of Landlord’s North Premises Work, and (ii) the General Conditions of the Cost of Landlord’s North Premises Work 

 

	 	•	 	 General Conditions Costs: 9% of the Direct Cost of Landlord’s North Premises Work

  

	 	•	 	 Direct Cost: Determined by bids obtained from subcontractors in accordance with Section 5 below.

  

	 	•	 	 Design Builder’s Contingency: 3% of the Cost of Landlord’s North Premises Work

 3. Preparation of Construction Documents. The Contractor and/or Landlord shall engage RE Dineen as a
subconsultant to prepare the North Premises Construction Documents for Tenant’s approval, which approval shall not be unreasonably withheld, conditioned, or delayed. 

4. Tenant Responses. 

(i) Tenant shall respond, in writing, to any requests from Landlord or the Contractor for information, consents, or
authorizations to proceed, within three (3) business days of Tenant’s receipt of such request. Any failure by Tenant to respond within such time period may be the basis of a Tenant Delay. 

(ii) Tenant shall have the right to hire a mutually approved Tenant Construction Representative to oversee all required
construction relative to the North Premises. 
 5. Bid Process. Tenant hereby acknowledges that: 

(i) the Contractor will receive a single bid for each of the following portions of Landlord’s North Premises Work from the
designated subcontractors (“Designated Subcontractors”) listed below who will perform such portions of Landlord’s North Premises Work: 

  
 EXHIBIT 4, PAGE 2 

	 	•	 	 Mechanical/HVAC: Environmental Systems, Inc. 

 

	 	•	 	 Plumbing: North Shore Mechanical Contractors, Inc. 

 

	 	•	 	 Fire Protection: Legacy Fire Protection, Inc. 

 

	 	•	 	 Electrical: Nappa Electric, Inc. 

(ii) Landlord will cause the Contractor to use reasonable efforts to obtain at least three (3) bidders for other portions
of Landlord’s North Premises Work; however, given the current market, it may not be possible to obtain more than one or two bidders with respect to portions of Landlord’s North Premises Work. 

(iii) Landlord shall, upon the written request of Tenant, from time to time, make available to Tenant, for Tenant’s
information, all bids, the construction contract, and any other construction agreement on which the North Premises Permitted Costs are based, and any Applications for Payment on which the actual North Premises Permitted Costs are based. 

If Tenant reasonably determines that the GMP is higher than is acceptable to Tenant, then Tenant shall have a
one-time right to give request changes to Landlord’s North Premises Work. In order to exercise such one-time right to request changes to Landlord’s North
Premises Work in order to reduce the GMP, Tenant shall, on or before the date three (3) business days after Tenant receives Landlord’s notice to Tenant of the GMP, give written notice to Landlord specifying the changes in Landlord’s
North Premises Work requested by Tenant. Such changes shall be subject to Landlord’s prior written approval (which approval shall not be unreasonably withheld, conditioned, or delayed). Based upon the revised North Premises Construction
Documents for Landlord’s North Premises Work, which are based upon the changes requested by Tenant, as approved by Landlord, as aforesaid, the Contractor shall revise the GMP for the construction of Landlord’s North Premises Work in
accordance with this Section 5. Tenant shall pay for the design cost associated the preparation of the revised North Premises Construction Documents. Tenant shall have the right to review the revised GMP within three (3) business days
after receipt thereof. 
 6. Tenant’s Share. For the purposes of this Exhibit 4: (i) if the Cost of Landlord’s North Premises Work
is equal to, or less than, the North Premises Maximum Amount, then “Tenant’s North Premises Share” shall be 0%, and (ii) if the Cost of Landlord’s North Premises Work is greater than the North Premises Maximum Amount,
then Tenant’s North Premises Share shall be a fraction, the numerator of which is the amount by which the total Cost of Landlord’s North Premises Work exceeds the North Premises Maximum Amount, and the denominator of which is the total
Cost of Landlord’s North Premises Work. 
 7. Tenant’s Obligation to Pay Excess Costs. 

(a) If the Cost of Landlord’s North Premises Work exceeds the North Premises Maximum Amount, Tenant shall, subject to Section 7(b)
below, pay to Landlord such excess costs (the “North Premises Excess Costs”) as follows: (i) Tenant shall pay Tenant’s 
 Share of
Landlord’s North Premises Excess Costs within thirty (30) days of Billing, as 

  
 EXHIBIT 4, PAGE 3 

 hereinafter defined, (ii) with respect to any Changes to Landlord’s North Premises Work, Tenant
shall pay for the cost of such changes in accordance with Section 8 below, and (iii) with respect to any increases in the Cost of Landlord’s North Premises Work arising from Claims by the Contractor, Tenant shall pay for the cost of
such Claims as set forth in Section 9 below. “Billing” shall be defined as any invoice from Landlord setting forth, reasonable detail, the amount due from Tenant, and shall include invoices from vendors and service providers,
and applications for payment from the Contractor for work completed through the date of Billing, as certified by the Contractor. Billing may not be submitted to Tenant more than one (1) time per calendar month. The amounts payable by Tenant
hereunder constitute Rent payable pursuant to the Lease, and the failure to timely pay same constitutes an event of default under the Lease. 

(b) Provided that each portion of the Premises (including, without limitation, the Expansion Premises, if Tenant timely and properly exercises
its right to lease the Expansion Premises) is improved to the Minimum Improvement Standard, as hereinafter defined, Tenant may, upon timely written election, apply: (i) a portion the Landlord’s South Premises Contribution towards
Tenant’s obligation to pay for the North Premises Excess Costs, as set forth in Section 7(a) above, and (ii) a portion of Landlord’s North Premises Contribution towards Tenant’s obligation to pay for the South Premises
Excess Costs (subject to Tenant’s compliance with Section II.7 of this Exhibit 4), and (iii) on the conditions that: (x) Tenant timely and properly exercises its right to lease the Expansion Space, as set forth in Section I of
Exhibit 11, and (y) Landlord’s Expansion Space Contribution is available for such use at the time that Tenant’s obligation to pay the North Premises Excess Cost is due. For purposes of this Lease, the “Minimum
Improvement Standard” shall be defined as the level and quality of leasehold improvements of typical office, laboratory, pilot production (and warehouse space associated with the pilot production) related to such office, laboratory, pilot
production and warehouse space associated with the pilot production, found in the Market Area, as defined in Section 1.2 of the Lease. Landlord expressly agrees that: (i) since Tenant is committed to the performance of Landlord’s
South Premises Work listed on Exhibits 4-3 and 4-4 attached hereto, the South Premises shall be deemed to be improved to the Minimum Improvement Standard,
and (ii) for the avoidance of doubt, Tenant has the right to apply any unused portion of the Landlord’s South Premises Contribution towards the North Premises Permitted Cost and (if Tenant timely and properly exercises its right to lease
the Expansion Premises) to the Expansion Premises Permitted Costs. 
 8. Changes. If Tenant shall request any change, addition or
alteration in any of the North Premises Initial Plan after approval by Landlord (“North Premises Change”), Landlord shall have such revisions to the drawings prepared. Promptly upon completion of the revisions, Landlord shall notify
Tenant in writing of the increased cost, if any, which will be chargeable to Tenant by reason of such change, addition or deletion. Tenant, within three (3) business days, shall notify Landlord in writing whether it desires to proceed with such
North Premises Change. In the absence of such written authorization, Landlord shall have the option to continue work on the North Premises disregarding the requested North Premises Change. To the extent that the cost of performing such revisions
cause the cost of Landlord’s North Premises Work to exceed the North Premises Maximum Amount, Tenant shall reimburse Landlord for the Cost of Landlord’s North Premises Work associated with such North Premises Change within thirty
(30) days of Billing, as such North Premises Change work is being performed (subject to Tenant’s right, as set forth in Section 7(a) above, to apply a portion of Landlord’s North Premises Contribution towards the Cost of such
North Premises Change work). 

  
 EXHIBIT 4, PAGE 4 

 9. Claims. To the extent that any claims (“Claims”) by the
Contractor cause the Cost of Landlord’s North Premises Work to exceed the North Premises Maximum Amount, Tenant shall pay for such excess within thirty (30) days of Billing. Claims shall include any amounts properly due to the Contractor
under the Contract based upon the claims of the Contractor under the Contract, provided however, that the Claims shall not include any amounts arising from the default or negligence of Landlord, or Landlord’s agents or employees, under the
Contract. 
 10. Performance of Landlord’s North Premises Work. Following approval of the North Premises Construction Documents
and Tenant’s written authorization to proceed with Landlord’s North Premises Work, Landlord shall cause the Landlord’s North Premises Work to be constructed in all material respects in accordance with the approved North Premises
Construction Documents. 
 11. Landlord’s North Premises Contribution: 

(a) Except as set forth in this Section 11: (i) any portion of Landlord’s North Premises Contribution which exceeds the Cost of the
Landlord’s North Premises Work shall accrue to the sole benefit of Landlord, and (ii) Tenant shall not be entitled to any credit, offset, abatement or payment with respect thereto. 

(b) Requisitions by Tenant for Other North Premises Permitted Costs. If there is any Remaining Portion of Landlord’s North Premises
Contribution, Tenant may submit Requisitions, as hereinafter defined, to Landlord to pay for Other North Premises Permitted Costs, as follows: 

(1) A “Requisition” shall mean (1) an application for payment (accompanied by, without limitation,
invoices from Tenant’s contractors, vendors, service providers and consultants (collectively, “Contractors”) listing in reasonable detail Other North Premises Permitted Costs, (2) a certification executed by an authorized
representative of Tenant that the amount of the Requisition in question does not exceed the cost of the items, services and work covered by such Requisition, and (3) only with respect to those items and services covered by such Requisition for
which mechanic’s lien rights arise under Massachusetts Law, partial lien waivers and subordinations of lien, as specified in M.G.L. Chapter 254, Section 32 (“Lien Waivers”). Landlord shall have the right, upon reasonable
advance notice to Tenant, to inspect Tenant’s books and records relating to each Requisition in order to verify the amount thereof. Tenant shall submit Requisition(s) no more often than monthly. 

(2) On the condition that Tenant is not in default of its obligations under the Lease at the time that Landlord receives a
Requisition, Landlord shall pay the amount properly due under such Requisition within thirty (30) days of receipt of such Requisition. Notwithstanding the foregoing, if Landlord declines 

  
 EXHIBIT 4, PAGE 5 

 
to pay Tenant on account of any Requisition based upon Tenant then being in default of its obligations under the Lease, and if Tenant subsequently cures such default, then Tenant shall have the
right to resubmit such Requisition, and Landlord shall pay the amount due on account of such Requisition, provided that the Lease is then in full force and effect and all of the conditions to payment on account of such Requisition are then
satisfied. 
 (3) Notwithstanding anything to the contrary herein contained: (i) Landlord shall have no obligation to
advance funds on account of Landlord’s North Premises Contribution more than once per month; (ii) if any contractor, subcontractor of any tier, or materialman records a Notice of Contract which is not discharged or bonded over by, on or
behalf of, Tenant, Landlord shall thereafter have the right to have the relevant portion of Landlord’s North Premises Contribution paid directly to such lienor upon receipt of requisite documentation from such lienor evidencing payment to be
due and owing, only upon Landlord notifying Tenant in writing of its intent to pay such portion of Landlord’s North Premises Contribution directly to such contractors and Tenant failing within five (5) business days of receipt of such
notice to (x) bond over or discharge such lien, as a matter of record or (y) pay such lienor (and provide evidence of such payment to Landlord) the amounts claimed owing to such lienor; (iii) Landlord shall have no obligation to pay
any portion of Landlord’s North Premises Contribution with respect to any Requisition submitted after the Outside Requisition Date, as hereinafter defined. Subject to the Section I.B(5) of Exhibit 11, the “Outside Requisition
Date” shall be the date ninety (90) days after Landlord gives Tenant written notice setting forth the final Cost of Landlord’s North Premises Work. 

(c) Tenant’s Right to Apply Landlord’s North Premises Contribution to South Premises Permitted Costs and Expansion
Premises Permitted Costs. Provided that each portion of the Premises (including, without limitation, the Expansion Premises, if Tenant timely and properly exercises its right to lease the Expansion Premises) is improved to the Minimum
Improvement Standard, as defined above, Tenant may, at Tenant’s written election, apply any unused portion of Landlord’s North Premises Contribution towards the South Premises Permitted Costs, as hereinafter defined, and the Expansion
Premises Permitted Costs, as hereinafter defined (if Tenant timely and properly exercises its right to lease the Expansion Premises). If Tenant makes such election, then the unused portion of Landlord’s North Premises Contribution so designated
by Tenant shall become part of Landlord’s South Premises Contribution and/or Landlord’s Expansion Premises Contribution, as the case may be. 

12. Landlord’s Warranty 

(a) Landlord’s Warranty. Landlord hereby warrants and represents to Tenant that Landlord’s North Premises Work shall be
performed: (i) in a good and workmanlike manner; (ii) in all material respects, in accordance with the North Premises Construction Documents, and (iii) in accordance with all applicable Legal Requirements. The Landlord warranty and
representations set forth in this Section 13(a) are referred to herein as “Landlord’s Warranty”. 

  
 EXHIBIT 4, PAGE 6 

 (b) Tenant’s Remedies in the Event of Breach of Landlord’s Warranty. If, on
or before the Warranty Expiration Date, Tenant gives Landlord written notice of any breach of Landlord’s Warranty promptly after Tenant becomes aware of such breach, Landlord shall, at no cost to Tenant, correct or repair such breach as soon as
conditions reasonably permit and as to which, in either case, Tenant shall have given notice to Landlord, as aforesaid. The “Warranty Expiration Date” shall be defined as the date eleven (11) months and two (2) weeks after
the North Premises Term Commencement Date. Except to the extent to which Tenant shall have given Landlord notice of respects in which Landlord has breached Landlord’s Warranty or Landlord has otherwise failed to perform Landlord’s
construction obligations under this Exhibit 4, Tenant shall be deemed conclusively to have: (i) approved Landlord’s North Premises Work, (ii) waived any claim that Landlord has breached Landlord’s Warranty, and
(iii) have agreed that Tenant has no claim that Landlord has failed to perform any of Landlord’s obligations under this Work Agreement. The provisions of this Section 12(b) sets forth the Tenant’s sole remedies for any breach of
the Landlord’s Warranty; however nothing in this Section 12(b) shall be deemed to relieve the Landlord of its responsibilities to perform maintenance and repairs as required pursuant to Section 10.2 of the Lease or affect or limit the
provisions of Section 10.7 of the Lease. With respect to any latent defects in Landlord’s North Premises Work discovered by Tenant after the Warranty Expiration Date, Landlord shall, upon request of Tenant, assign to Tenant its rights
against any contractor, subcontractor, and/or designer engaged by Landlord in connection with Landlord’s North Premises Work to the extent necessary to enable Tenant to assert claims against such contractor, subcontractor and/or designer in
connection with such latent defect. 
  

	II.	 South Premises 

Reference is made to the fact that the leasehold improvements to be performed in the South Premises will be performed in two phases:
(i) Landlord will initially perform Landlord’s South Premises Work, as hereinafter defined, and in accordance with Section II.A below, and (ii) Tenant shall be responsible for any improvements to be performed in the South Premises
after Landlord completes Landlord’s South Premises Work.  
  

	 	A.	 Landlord’s South Premises Work 

1. Tenant acknowledges and agrees that Tenant is leasing the South Premises in their “AS IS,” “WHERE IS”
condition and with all faults on the Execution Date, without representations or warranties, express or implied, in fact or by law, of any kind, and without recourse to Landlord, except that Landlord shall perform Landlord’s South Premises Work,
as hereinafter defined, in accordance with the provisions of Section 3 of the Lease, this Section II, Exhibit 4, and Landlord shall provide Landlord’s South Premises Contribution, as hereinafter defined. Landlord’s South
Premises Work shall be performed subject to the same terms and conditions as are applicable to the performance of Landlord’s North Premises Work, as set forth in Section I of this Exhibit 4, except as set forth in this Section II of
Exhibit 4. 

  
 EXHIBIT 4, PAGE 7 

 2. Landlord’s South Premises Work is based upon the Architectural Basis of Design
attached hereto as Exhibit 4-3 and the schematic plan (“Initial Plan for South Premises”) attached hereto as Exhibit 4.4. 

3. Landlord shall apply Landlord’s South Premises Contribution in accordance with Section B.7 of this Section II towards the cost of
Landlord’s South Premises Work. 
  

	 	B.	 Tenant’s South Premises Work 

1. Tenant’s Plans. All leasehold improvements to the South Premises after the completion of Landlord’s South Premises Work
(“Tenant’s South Premises Work”) shall be performed in accordance with the provisions of the Lease, including, without limitation, this Section B. Tenant shall submit to Landlord for Landlord’s approval (i) the name
of and other reasonably requested information regarding Tenant’s proposed architect, HVAC and MEP engineers and general contractor, Landlord hereby reserving the right to require that Tenant use a MEP engineer selected by Landlord; (ii) on
or before October 1, 2020, a set of design/ development plans sufficient for Landlord to approve Tenant’s proposed design of the Premises (the “Design/ Development Plans”), and on or before January 1, 2021, a full set
of construction drawings (“Final Construction Drawings”) for Tenant’s South Premises Work. The Design/Development Plans and the Final Construction Drawings are collectively referred to herein as the “Tenant’s
Plans.” Landlord’s approval of the architect, HVAC and MEP engineers and general contractor shall not be unreasonably withheld, conditioned or delayed. In addition, Landlord shall have the right to require its written approval, which shall
not be unreasonably withheld, conditioned, or delayed, of any subcontractors performing any work affecting the structural elements of, or any of the utility or building service equipment or systems in, the Building. Landlord’s approval of the
Design/Development Plans (and the Final Construction Drawings, provided that the Final Construction Drawings are consistent with the Design/Development Plans), shall not be unreasonably withheld, conditioned or delayed provided the Tenant’s
Plans comply with the requirements to avoid aesthetic or other conflicts with the design and function of the balance of the Building and the Property. Landlord’s approval is solely given for the benefit of Landlord and Tenant under this
Section 1 and neither Tenant nor any third party shall have the right to rely upon Landlord’s approval of the Tenant’s Plans for any other purpose whatsoever. Landlord agrees to respond to any request for approval of the Tenant’s
Plans within ten (10) business days after receipt thereof. 
 2. Performance of Tenant’s South Premises Work. Tenant’s
South Premises Work shall be performed by Tenant in accordance with the provisions of the Lease (including, without limitation, Section 11 of the Lease and this Exhibit 4). Tenant’s South Premises Work shall be performed at
Tenant’s sole cost and expense, except for: (i) Landlord’s South Premises Contribution, (ii) Landlord’s North Premises Contribution, and (ii) Landlord’s Expansion Premises Contribution, on the conditions that:
(x) Tenant timely and properly exercises its right to lease the Expansion Space, as set forth in Section I of Exhibit 11, and (y) Landlord’s Expansion Space Contribution is available for such use at the time that Tenant submits
requisitions for South Premises Permitted Costs. 

  
 EXHIBIT 4, PAGE 8 

 3. Completion of Tenant’s South Premises Work. Tenant shall Substantially
Complete (hereinafter defined) Tenant’s South Premises Work on or before June 30, 2021 (the “Outside Tenant Work Completion Date”), provided that if Tenant is delayed in the performance of Tenant’s Work by reason of a
Landlord Delay (as hereinafter defined), the Outside Tenant Work Completion Date shall be extended by the length of such Landlord Delay. For purposes hereof, Tenant’s South Premises Work shall be deemed “Substantially Complete”
and “Substantial Completion” shall be deemed to have occurred if Tenant has and delivered to Landlord a copy of (i) a certificate of substantial completion from Tenant’s architect for Tenant’s South Premises Work, and
(ii) a certificate of occupancy for the South Premises from the Town of Lexington, Massachusetts. A “Landlord Delay” shall be defined as any default by Landlord in its obligations under the Lease that causes an actual delay in
the completion of Tenant’s South Premises Work. Notwithstanding the foregoing, no event shall be deemed to be a Landlord Delay until and unless Tenant has given Landlord written notice (the “Landlord Delay Notice”) advising
Landlord (i) that a Landlord Delay is occurring, (ii) of the basis on which Tenant has determined that a Landlord Delay is occurring, and (iii) the actions which Tenant believes that Landlord must take to eliminate such Landlord
Delay, and Landlord has failed to correct the Landlord Delay specified in the Landlord Delay Notice within forty-eight (48) hours following receipt thereof. No period of time prior to expiration of such forty-eight-(48)-hour period shall be
included in the period of time charged to Landlord pursuant to such Landlord Delay Notice. 
 4. Cost of Tenant’s South Premises
Work. Except for: (i) Landlord’s South Premises Contribution, (ii) any unused portion of Landlord’s North Premises Contribution (subject to Tenant’s compliance with Section I.11(c) of this Exhibit 4), and
(iii) Landlord’s Expansion Premises Contribution, on the conditions that: (x) Tenant timely and properly exercises its right to lease the Expansion Space, as set forth in Section I of Exhibit 11, and (y) Landlord’s
Expansion Premises Contribution is available for such use at the time that Tenant’s obligation to pay Excess Cost is due, all of Tenant’s South Premises Work shall be performed at Tenant’s sole cost and expense, and shall be performed
in accordance with the provisions of this Lease (including, without limitation, Section 11 of the Lease). 
 5.
Landlord’s South Premises Contribution. As an inducement to Tenant’s entering into this Lease, Landlord shall, subject to the provisions of this Section II.5, provide to Tenant a tenant improvement allowance
(“Landlord’s South Premises Contribution”) of up to $2,007,750.00 (i.e., up to $150.00 per rentable square foot of the South Premises (the “Maximum Amount of Landlord’s South Premises Contribution”).
Landlord shall apply Landlord’s South Premises Contribution towards the cost of Landlord’s South Premises Work. The balance (“Balance”) of Landlord’s South Premises Contribution shall be available for use by Tenant
solely for Permitted Costs incurred by Tenant in Tenant’s Work (“South Premises Permitted Costs”), provided however, that no more than $200,775.00 of Landlord’s South Premises Contribution may be applied to Soft Costs and
Other Permitted Costs 
 6. Budget. Tenant shall have no right to submit any requisition to Landlord on account of South Premises
Permitted Costs until: (x) after the completion of Landlord’s South Premises Work, and (y) Tenant has submitted to Landlord a detailed good faith budget (“Budget”) of South Premises Permitted Costs. Tenant shall
deliver to Landlord an update of the Budget at least once every two (2) months, but in any event after Tenant enters into a contract for the performance of Tenant’s Work with its contractor. 

  
 EXHIBIT 4, PAGE 9 

 (i) Tenant shall submit to Landlord reasonably detailed documentation
evidencing the then current Budget at the time of each Budget update. For the purposes hereof, South Premises Permitted Costs shall not include: (x) the cost of any of Tenant’s Property (hereinafter defined) (other than the cost of
installing Tenant’s data, telecom and cabling in the Premises), any de-mountable decorations, artwork and partitions, signs, and trade fixtures, (y) the cost of any fixtures or Alterations that will
be removed at the end of the Term, and (z) any fees paid to Tenant, any Affiliated Entity or Successor, 
 (ii)
Requisitions. Landlord shall pay Landlord’s Proportion (hereinafter defined) of the cost shown on each requisition (hereinafter defined) submitted by Tenant to Landlord within thirty (30) days of submission thereof by Tenant to
Landlord until the entirety of Landlord’s Contribution has been exhausted. “Landlord’s Proportion” shall be a fraction, the numerator of which is the Balance (as defined in Section 5 above) of Landlord’s South
Premises Contribution and the denominator of which the Budget for South Premises Permitted Costs, from time to time. A “requisition” shall mean AIA Documents G-702 and G-703 duly executed and certified by Tenant’s architect and general contractor (accompanied by, without limitation, invoices from Tenant’s contractors, vendors, service providers and consultants
(collectively, “Contractors”) and partial lien waivers and subordinations of lien, as specified in M.G.L. Chapter 254, Section 32 (“Lien Waivers”) with respect to the prior month’s requisition, and such
other documentation as Landlord or any Mortgagee may reasonably request) showing in reasonable detail the costs of the item in question or of the improvements installed to date in the Premises, accompanied by certifications executed by the Chief
Executive Officer, Chief Financial Officer, Chief Operations Officer, Vice President, or other officer of Tenant that the amount of the requisition in question does not exceed the cost of the items, services and work covered by such requisition.
Landlord shall have the right, upon reasonable advance notice to Tenant and not more often than one time per calendar month, to inspect Tenant’s books and records relating to each requisition in order to verify the amount thereof. Such
inspection shall be at Landlord’s sole cost and expense. Tenant shall submit requisition(s) no more often than monthly. 

(iii) Notwithstanding anything to the contrary herein contained: (1) Landlord shall have no obligation to advance funds on
account of Landlord’s South Premises Contribution more than once per month; (2) if Tenant fails to pay to Tenant’s contractors the amounts paid by Landlord to Tenant in connection with any previous requisition(s), Landlord shall
thereafter have the right to have Landlord’s South Premises Contribution paid directly to Tenant’s contractors; (3) subject to Section I.B(5) of Exhibit 11, Landlord shall have no obligation to pay any portion of
Landlord’s South Premises Contribution June 30, 2021 (the “Outside South Premises Requisition Date”); provided, however, that if Tenant certifies to Landlord that it is engaged in a good faith dispute with any
contractor, such Outside South Premises Requisition Date shall be extended while such dispute is ongoing, so long as Tenant is diligently prosecuting the resolution of such dispute; (4) Tenant shall not be entitled to any unused portion of

  
 EXHIBIT 4, PAGE 10 

 
Landlord’s South Premises Contribution; (5) Landlord’s obligation to pay any portion of Landlord’s South Premises Contribution shall be conditioned upon there existing no
Event of Default by Tenant in its obligations under this Lease at the time that Landlord would otherwise be required to make such payment; and (6) in addition to all other requirements hereof, Landlord’s obligation to pay the final ten
percent (10%) of Landlord’s South Premises Contribution shall be subject to simultaneous delivery of all Lien Waivers relating to items, services and work performed in connection with Tenant’s Work. If Landlord declines to fund any
requisition on the basis that, at the time that Tenant submitted such requisition to Landlord, Tenant is in default of its obligations under the Lease, then, if Tenant cures such default and so long as the Lease is still in full force and effect,
Tenant shall again have the right to resubmit such requisition (as may be updated by Tenant for any work performed since the date of the previously submitted requisition) for payment subject to the terms and conditions of this Section II.6. 

7. Tenant’s Right to Apply Landlord’s South Premises Contribution to North Premises Permitted Costs and Expansion Premises
Permitted Costs. Provided that each portion of the Premises (including, without limitation, the Expansion Premises, if Tenant timely and properly exercises its right to lease the Expansion Premises) is improved to the Minimum Improvement
Standard, as defined above, Tenant may, at Tenant’s written election, apply any unused portion of the Landlord’s South Premises Contribution and the Landlord’s Expansion Premises Contribution (if applicable) towards the North Premises
Permitted Costs, the South Premises Permitted Costs, and the Expansion Premises Permitted Costs (all as hereinafter defined), and as to the Expansion Premises Permitted Costs only if Tenant timely and properly exercises its right to lease the
Expansion Premises. Landlord expressly agrees that: (i) since Tenant is committed to the performance of Landlord’s South Premises Work listed on Exhibits 4-3 and 4-4 attached hereto, the South Premises shall be deemed to be improved to the Minimum Improvement Standard, and (ii) for the avoidance of doubt, Tenant has the right to apply any unused portion of the
Landlord’s South Premises Contribution towards the North Premises Permitted Cost and (if Tenant timely and properly exercises its right to lease the Expansion Premises) to the Expansion Premises Permitted Costs. If Tenant makes such election,
then the unused portion of Landlord’s South Premises Contribution and Landlord’s Expansion Premises Contribution (if applicable) so designated by Tenant shall become part of Landlord’s North Premises Contribution and/or
Landlord’s South Premises Contribution, and /or Landlord’s Expansion Premises Contribution, as the case may be. 
  

	III.	 Miscellaneous 

1. Tenant’s Authorized Representative. Tenant designates Jeffrey Moore (email: jeffrey.moore@kaleido.com; telephone (617)-674-9000) and Richard Donovan (email: rick@RJdonovangroup.com; telephone: (508) 380-9806) (collectively, “Tenant’s
Representative”) as the only person authorized to act for Tenant pursuant to this Work Letter. Landlord shall not be obligated to respond to or act upon any request, approval, inquiry or other communication
(“Communication”) from or on behalf of Tenant in connection with this Work Letter unless such Communication is in writing from Tenant’s Representative. Tenant may change either Tenant’s Representative at any time upon not
less than five (5) business days advance written notice to Landlord. 

  
 EXHIBIT 4, PAGE 11 

 2. Landlord’s Authorized Representative. Landlord designates Stephen
Lynch (email: slynch@ks-prop.com; telephone: 617-910-5500; “Landlord’s Representative”) as the only
person authorized to act for Landlord pursuant to this Work Letter. Tenant shall not be obligated to respond to or act upon any request, approval, inquiry or other Communication from or on behalf of Landlord in connection with this Work Letter
unless such Communication is in writing from Landlord’s Representative. Landlord may change either Landlord’s Representative at any time upon not less than five (5) business days advance written notice to Tenant. 

 

	IV.	 Disputes. 

Any disputes relating to provisions or obligations in this Lease in connection with Landlord’s Work or this Exhibit 4 shall be
submitted to arbitration in accordance with the provisions of applicable state law, as from time to time amended. Arbitration proceedings, including the selection of an arbitrator, shall be conducted pursuant to the rules, regulations and procedures
from time to time in effect as promulgated by the American Arbitration Association. Notwithstanding the foregoing, the parties hereby agree that the arbitrator for any disputes relating to Landlord’s Work shall be a construction consultant
experienced in the construction of offices/research/laboratory buildings/campuses in the Route 128/Route 2/Alewife corridor real estate market, as mutually agreed upon by the parties, or, if not then designated by the parties, within ten
(10) days after either party makes a request for arbitration hereunder, or (if the parties do not mutually agree upon such arbitrator) as designated by the Boston office of the American Arbitration Association upon request by either party.
Prior written notice of application by either party for arbitration shall be given to the other at least ten (10) days before submission of the application to the said Association’s office in Boston, Massachusetts. The arbitrator shall
hear the parties and their evidence. The decision of the arbitrator shall be binding and conclusive, and judgment upon the award or decision of the arbitrator may be entered in the appropriate court of law; and the parties consent to the
jurisdiction of such court and further agree that any process or notice of motion or other application to the Court or a Judge thereof may be served outside the Commonwealth of Massachusetts by registered mail or by personal service, provided a
reasonable time for appearance is allowed. The costs and expenses of each arbitration hereunder and their apportionment between the parties shall be determined by the arbitrator in his award or decision. Except where a specified period is referenced
in this Lease, no arbitrable dispute shall be deemed to have arisen under this Lease prior to the expiration of the period of twenty (20) days after the date of the giving of written notice by the party asserting the existence of the dispute
together with a description thereof sufficient for an understanding thereof. In connection with the foregoing, it is expressly understood and agreed that the parties shall continue to perform their respective obligations under the Lease during the
pendency of any such arbitration proceeding hereunder (with any adjustments or reallocations to be made on account of such continued performance as determined by the arbitrator in his or her award). 

  
 EXHIBIT 4, PAGE 12 

 EXHIBIT 4-1 

INITIAL PLAN FOR NORTH PREMISES 
  

 

  
 EXHIBIT 4-1, PAGE 1 

 EXHIBIT 4-2 

UTILITY EQUIPMENT MATRIX—NORTH PREMISES 
  

 

  
 EXHIBIT 4-2, PAGE 1 

 

 

  
 EXHIBIT 4-2, PAGE 2 

 

 

  
 EXHIBIT 4-2, PAGE 3 

 

 

  
 EXHIBIT 4-2, PAGE 4 

 

 

  
 EXHIBIT 4-2, PAGE 5 

 

 

  
 EXHIBIT 4-2, PAGE 6 

 EXHIBIT 4-3 

ARCHITECTURAL BASIS OF DESIGN 

ARCHITECTURAL 
 BASIS OF
DESIGN 
  
 

 
 65 Hayden Avenue, 1st Floor 

Lexington, Massachusetts 

  
 EXHIBIT 4-3, PAGE 1 

			
	ROOM NAME/NUMBER:	  	Reception Area
		  	Airlock, Waiting Area, Board Room.
		
	FUNCTION:	  	Reception and Conference
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	Tenant Standard Broadloom and Modular Carpet tiles in selected areas. Vinyl Plank tile or other resilient flooring in waiting area. Surface mounted walk-off mat—airlock. Wall Base to
be 4” high straight or cove.
		
	 Wall Finish:
	  	Tenant Standard eggshell finish, latex paint—Benjamin Moore Color TBD. Glazed walls and transoms.
		
	 Ceiling Height/Finish:
	  	10’-0” AFF; with some 9’-0” areas per RCP, 2’x2’ tegular acoustical tile (white) Armstrong Dune or
Equal—9/16” Fineline grid (white), and GWB ceiling soffit with smooth finish on metal stud system at various heights, Conference/Break room GWB accent celling system.
		
	 Door/Frame/Hardware:
	  	Storefront glass entrance walls and doors at Airlock. Butt glazed wall and glass door hardware to open office. Card readers per plan.
		
		  	Board Room and meeting rooms to either be de-mountable glazed wall/door systems by furniture vendor, or butt glazed door and glazed wall by general contractor, which will be decided based
on the teams effort to fit this scope within the budget.
		
	 Millwork:
	  	Reception Desk: cabinets shall be premium plastic laminate base and wall units, with solid surface counter. Coffee Bar: cabinets shall be premium plastic laminate base and wall units, with solid surface counter and glass tile
backsplash to the underside of wall cabinet above. Board Room: Provide alternate for built-in premium plastic laminate millwork benches.
		
	 Window Treatment:
	  	Sun control “Electroshades” shades at exterior glazing and Board Room surround.
		
	EQUIPMENT:	  	Provide water feed for Coffee maker. Under-counter fridge at coffee station. Projection screen in large conf. room. Wall mounted TVs, Projector, A/V components, appliances and office equipment by others.
		
	ROOM NAME/NUMBER:	  	General Office Areas
		  	Open Office, Meeting rooms, Break Room, Server
		
	FUNCTION:	  	Office and Meeting Space

  

			
		  	2
		  	

  
 EXHIBIT 4-3, PAGE 2 

 KSP—Kaleido BioSciences 

65 Hayden Ave, Lexington, MA 
  

			
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	Tenant Standard Broadloom and Modular Carpet tiles in selected areas—Offices and open offices areas. Wall Base to be 4” high straight or cove. Existing vinyl flooring to be covered with carpet at exterior wall line.
Break Room flooring to be vinyl plank tile or other resilient flooring. Server room to be ESD VCT.
		
	 Wall Finish:
	  	Tenant Standard eggshell finish, latex paint—Benjamin Moore Color TBD. Existing window film to be removed from existing storefront glazing systems at offices and meeting rooms.
		
	 Ceiling Height/Finish:    
	  	Open office areas 10’-0”, with offices at 9’-0” AFF; 2’x2’ tegular acoustical tile (white) Armstrong Dune
or Equal—9/16” Fineline grid (white), and GWB ceiling soffits with smooth finish on metal stud system at various heights. Break room 10’-0: AFF ACT ceiling with GWB soffit at exterior
curtain wall. GWB Soffit 8’-0” AFF at office and meeting room front walls. GWB Soffit 8’-0” AFF surrounding perimeter of enclosed
workstations.
		
	 Door/Frame/Hardware:
	  	 Office and meeting room doors to be 8 ft high De-mountable glazed wall/door systems by furniture
vendor. Butt glazed wall and glass door hardware to Break Room.
  
 Other Doors—3’-0“x7’-0” flush metal doors painted.
 Card
readers with electric strikes per plan.
 Frames—Hollow metal, semi-gloss latex paint finish.

Hardware—Building standard Schlage Cylindrical Lockset, Athens Lever Design, finish 626 “satin chromium plated”; Hinge—Stanley full mortise
FBB179 ANSI A8112, 4-1/2” x 4-1/2” steel; Silencers; Floor stop—Rockwood 441 in finish “satin chrome”. Closers, flush bolts,
silencers.

		
	 Millwork:
	  	Break Room & Reception Coffee Bar: kitchen cabinets shall be premium plastic laminate base and wall units, with solid surface counter and glass tile backsplash to the underside of wall cabinet above.
		
		  	Coats/Copy Area/Mailroom: premium plastic laminate base/wall units and countertop; Coat rod and shelf. Lockers by others.
		
	 Window Treatment:
	  	Sun control “Electroshades” shades at exterior glazed curtain wall facing courtyard at Open Office and Breakroom. Building standard Mechoshades for others.
		
	EQUIPMENT:	  	Provide water feed for Coffee maker at all coffee stations. Undercounter fridge at all coffee stations. Wall mounted TVs, A/V components, kitchen appliances and office equipment by others.

  

			
		  	3
		  	

  
 EXHIBIT 4-3, PAGE 3 

 KSP—Kaleido BioSciences 

65 Hayden Ave, Lexington, MA 
  

			
	ROOM NAME/NUMBER:	  	Laboratories & Support Spaces
		
	FUNCTION:	  	Multi-purpose R & D laboratory environment.
		
	ARCHITECTURAL:	  	
		
	Flooring:	  	Biology and support areas to be vinyl composition tile with wall Base—4” high coved. Glasswash & storage epoxy flooring to remain—repair as needed. Chemistry Lab VCT flooring to remain—remove existing
accent tiles and repair as needed. Chemistry equipment room existing epoxy floor to remain. Shipping area and freezer farms to be vinyl composition tile with wall Base—4” high coved. Lab corridors existing to remain with repairs as
needed—use house stock.
		
	Wall Finish: 	  	Tenant Standard eggshell finish, latex paint. Glasswash and Waste Room to have epoxy paint.
		
	Ceiling Height/Finish:	  	Biology, Shipping, Freezer Farms: 9’-0” AFF; 2’-0” x 4’-0” x 1/2” ClimaPlus,
vinyl faced, square edged tile (white); Chemistry, Glasswash, Chem Equipment, Consumable Storage, and Lab Corridors existing to remain, unless removed for HVAC re-work—replace damaged and soiled tiles.
Remove drywall “cube soffits” and infill with GWB in corridors.
		
	Door/Frame/Hardware:	  	Pair Doors—3’-0”/2’-0”x7’-0” flush metal doors to labs per plan. Half-lite in
active leaf. Card readers with electric strikes per plan. Frames—Hollow metal, semi-gloss latex paint finish. Hardware—Building standard Schlage Cylindrical Lockset, Athens Lever Design, finish 626 “satin chromium plated”;
Hinge—Stanley full mortise FBB179 ANSI A8112, 4-1/2” x 4-1/2” steel; Silencers; Floor stop—Rockwood 441 in finish “satin chrome”. Closers, flush bolts, armor plate,
silencers—or equal.
		
	Interior Glazing:	  	Glass in metal frame glazing system at lab/office walls and lab corridor “borrowed” lights and transoms per plan.
		
	Casework:	  	Fixed sink base cabinet—5’-0”long x 2’-6” deep, painted metal. Mobile table benches (New England Lab Cambridge Series or Equal)
5’-’0” and 6’-0” long x 2’-6” wide, painted metal table frames with suspended metal casework; P. Lam. reagent shelving; Bench
tops—1” thick epoxy, color “black”; drying racks above sink. BWK to Inventory existing flexible casework on site and re-use where possible (Existing laminate tops to be replaced with
1” epoxy). 6’-0” fume hood(s) with power per plan and utilities per matrix (Relocated and modified for constant volume on site). 2x2 Ceiling utility panels per RCP—Locate two per long
peninsulas with vacuum and compressed air where required. Glasswash stainless steel countertop with integral double bowl sink existing to remain. Re-use existing glasswasher. New Tuttnauer 5596 ECP (or Equal)
Autoclave.

  

			
		  	4
		  	

  
 EXHIBIT 4-3, PAGE 4 

 KSP—Kaleido BioSciences 

65 Hayden Ave, Lexington, MA 
  

			
	 EQUIPMENT:
	  	Wire partition system at loading dock area with caged roof. Lab equipment, floor and bench mounted, and BioSafety Cabinets by others.
		
	ROOM NAME/NUMBER:	  	South Building
		  	Large Conference, Collaboration, Meeting Rooms.
		
	FUNCTION:	  	Meeting Space
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	Midgrade Broadloom Carpet throughout. Wall Base to be 4” high straight.
		
	 Wall Finish:
	  	Tenant Standard eggshell finish, latex paint—Benjamin Moore Color TBD. Wink wall (writable surfaces).
		
	 Ceiling Height/Finish:
	  	9’-0” AFF, 2’x4’ square edge acoustical tile (white)—15/16” grid (white).
		
	 Door/Frame/Hardware:
	  	Doors—3’-0”x7’-0” flush metal doors painted. Half-lite in active leafs. Card readers with electric strikes per plan.
Frames—Hollow metal, semi-gloss latex paint finish. Hardware—Building standard Schlage Cylindrical Lockset, Athens Lever Design, finish 626 “satin chromium plated”; Hinge—Stanley full mortise FBB179 ANSI A8112, 4-1/2” x 4-1/2” steel; Silencers; Floor stop-Rockwood 441 in finish “satin chrome”. Closers, flush bolts, silencers.
		
	 Millwork:
	  	None
		
	 Window Treatment:
	  	Dual “Mechoshades” shades at exterior glazing with sun control and room darkening.
		
	EQUIPMENT:	  	Electric Projection screen and projection power lift in Assembly Space. Telephone rooms, Projector, A/V components, wall mounted TVs by others.

  

			
		  	5
		  	

  
 EXHIBIT 4-3, PAGE 5 

 EXHIBIT 4-4 

INITIAL PLAN FOR SOUTH PREMISES 
 

 

  
 EXHIBIT 4-4, PAGE 1 

 EXHIBIT 5-1 

AREAS AVAILABLE TO TENANT IN SOUTH PENTHOUSE 
 

 

  
 EXHIBIT 5-1, PAGE 1 

 EXHIBIT 5-2 

AREAS AVAILABLE TO TENANT IN SOUTH MECHANICAL ROOM 
 

 

  
 EXHIBIT 5-2, PAGE 1 

 EXHIBIT 5-3 

TENANT-SUPPLIED MECHANICAL EQUIPMENT LOCATION 
  

 

  
 EXHIBIT 5-3, PAGE 1 

 EXHIBIT 6 

FORM OF LETTER OF CREDIT 
 

 
 STANDBY LETTER OF CREDIT 

DRAFT of Standby Letter of Credit 

Draft for discussion purposes only 

begin format 
  

			
	BENEFICIARY:	  	Letter of credit number: 2010100000XX
	HCP/King Hayden Campus LLC	  	Date: xx/xx/xx
	200 Cambridge Park Drive	  	
	Cambridge, MA 02140
	Attn: Building Manager	  	

 Ladies and Gentlemen: 
 At the
request and for the account of Kaleido Biosciences, Inc., 18 Crosby Drive, Bedford, MA 01730, we hereby establish our standby letter of credit number 2010100000XX in your favor in the amount of two million fifty seven thousand six hundred fifty
eight U.S. dollars and seventy five cents (USD2.057,658.75) (hereinafter the “maximum amount”) available with us at our office listed below, by payment of your draft(s) drawn on us at sight accompanied by the following: 

 

	 	1.	 The original of this letter of credit and all amendments (if any). 

 

	 	2.	 Statement purportedly signed by the beneficiary stating the following: 

	 	“This	 demand is pursuant to me lease dated xx/xx/xx by and between the applicant and the Beneficiary as
amended.” 

 Partial drawings under this letter of credit are permitted. We shall, after each presentation of this letter of credit,
return the same to you, marking this letter of credit to show the amount paid by us and the date of such payment. 
 Each draft must be marked “Drawn
under Pacific Western Bank letter of credit number 2010100000XX.” 
 This letter of credit expires at our office listed below at 5 p.m. eastern time on
March 16, 2019. 
 Notwithstanding the foregoing, this letter of credit shall be automatically extended for a period of one year unless at least sixty
(60) calendar days prior to any expiration date we have sent written notice to your above address by courier that we elect not to renew this letter of credit for such additional period. In any event, this letter of credit will not be
extended beyond March 16, 2029. 
 Notwithstanding any provision herein to the contrary, our aggregate obligation to honor such drafts shall not
exceed the maximum amount, as reduced by prior draws hereunder. 
 If any instructions accompanying a drawing under this letter of credit request that
payment is to be made by transfer to an account with us or at another bank, we and/or such other bank may rely on an account number specified in such instructions even if the number identifies a person or entity different from the intended payee.

 Pacific Western Bank, 475 Fifth Ave, 18th Floor, New York, N.Y. 10017 

  
 EXHIBIT 6, PAGE 1 

 

 
 This Letter of Credit is transferable one or more times, but in each instance to a single transferee and only in the full
amount available to be drawn under the Letter of Credit at the time of such transfer. Any such transfer may be effected only through ourselves and only upon presentation to us at our below-specified office of a duly executed instrument of transfer
in the format attached hereto as Exhibit A together with the original of this letter of credit. Each transfer shall be evidenced by our endorsement on the reverse of the original of this letter of credit, and we shall deliver the original of this
letter of credit so endorsed to the transferee. Without prejudice to the foregoing, such transfer shall be permitted without our approval, provided that such transfer is not in favor of any person or entity identified on a then-current list of
specially Designated Nationals and Blocked Persons provided by the Office of Foreign Assets Control of the U.S. Department of the Treasury. All charges in connection with any transfer under this letter of credit shall be paid by the applicant at the
time written notice of a transfer is submitted. The payment of transfer charges shall not be a condition to the transfer of the Letter of Credit, as provided above. 

This letter of credit shall be promptly surrendered to us by you (or any subsequent transferee) upon expiration. 

Except So far as otherwise expressly stated, this documentary credit is subject to Uniform Customs and Practice for Documentary Credits, 2007 revision,
International Chamber of Commerce Publication No. 600. 
 We engage with you that each draft drawn under and in compliance with the terms of this
letter of credit will be duly honored on delivery of the specified documents, if presented (i) by courier or in person to this office during regular business hours: 475 Fifth Ave, 18th Floor, New
York, NY 10017 or (ii) via facsimile to 646.336.4961. 
 To the extent a presentation is made by facsimile, and to ensure timely payment, you must provide
telephone notification thereof to us at 646.467.5256, prior to or simultaneously with the sending of such facsimile transmission. A (“fax drawing”); will not be effectively presented until you confirm by telephone of our receipt of such
fax drawing. If you present a fax drawing under this letter of credit you do not need to present the original of any drawing documents, and if we receive any such original drawing documents they will not be examined by us. In the event of a full or
final drawing the original standby letter of credit must be returned to us by overnight courier. 
 In the event that your presentation is via facsimile
with confirmation of receipt of presentation via phone, you are not required to submit the original letter of credit, however, we will mark our records accordingly sending you an advice of the paid drawing and indicating the balance of the reduced
maximum amount, which will become an integral part of this letter of credit. 
  

	
	Very truly yours,
	
	Pacific Western Bank

 end format 

Agreed to and accepted by: 
  

 
 Pacific Western Bank, 475
Fifth Ave, 18th Floor, New York, N.Y. 10017 

  
 EXHIBIT 6, PAGE 2 

 EXHIBIT 7 

LANDLORD’S SERVICES 
 1. Hot
and cold water to the Common Area lavatories and the Premises, including both office and laboratory space. 
 2. Electricity for Building
Common Areas and the Premises [Note: Electricity to the Premises shall be submetered.] 
 3. HVAC services to the Building Common Areas and
the Premises, including both office and laboratory space. 
 4. Elevator service. 

5. Trash removal. 
 6. Snow
removal. 
 7. Exterior grounds and parking maintenance. 

8. Management services. 
 9.
Campus security systems, including (i) security personnel staffing a security station in the lobby of the Building during normal business hours and (ii) security personnel located on the Campus, with periodic patrols, 24 hours per day, 7
days per week. 
 10. Maintenance of life safety systems (fire alarm and sprinkler). 

11. Access to the following shared laboratory systems on a pro-rata basis: 

 

	 	a)	 Vacuum 

  

	 	b)	 Compressed Air 

  

	 	c)	 RO/DI Water 

12. Such other services as Landlord reasonably determines are necessary or appropriate for the Property. 

  
 EXHIBIT 7, PAGE 1 

 EXHIBIT 8 

TENANT’S HAZARDOUS MATERIALS 

See attached list. 

  
 EXHIBIT 8, PAGE 1 

							
	 name
	  	amount in stock	  	 Unit Size
	  	 location

	 (-)-Epigallocatechin Gallate
	  	1	  	1 g	  	Mini Fridge
	 1,1,3,3-Tetramethyldisiloxane
	  	1	  	100 g	  	Flammable Cabinet 1
	 1,2-ethanesulfonic acid
	  	1	  	5 g	  	Hood 2 acid
	
1,2-O-Isopropylidene-alpha-d-glucofuranose, 100 g
	  	1	  	100 g	  	Mini Fridge
	 1,4-Dioxane
	  	3	  	100 mL	  	Flammable Cabinet 1
	
l,8-Diazabicyclo(5.4.0)Undec-7-Ene,
 98%
	  	1	  	100 g	  	FH5 Bases
	 10% Palladium on Carbon in Water
	  	1	  	5 g	  	Inorganic Shelf
	 10% Palladium on Carbon in Water
	  	1	  	5 g	  	Inorganic Shelf
	 10% Palladium on Carbon in Water
	  	1	  	5 g	  	Inorganic Shelf
	 l0g 1,2,3,4,6-Penta-O-acetyl-alpha-D-mannopyranose
	  	1	  	100 g	  	Mini Fridge
	 1-Butanol
	  	1	  	1 L	  	Hood 7
	
l-Ethyl-3-Methylimidazolium
 Tetrafluorob
	  	1	  	100 g	  	FH3 Flammables
	 1-Heptanol, >=99.5%Gc
	  	1	  	5 g	  	Hood 2
	 1M borane thf
	  	4	  	100 mL	  	mini fridge
	
l-Methyl-2-Pyrrolidinone,
 For Hplc, >=9
	  	2	  	100 ml	  	FH3 Flammables
	 1-Methylimidazole
	  	2	  	100 g	  	Media Room
	 1-methylimidazole, reagentplus, 99%
	  	2	  	100 g	  	FH5 Bases
	 1-Methylimidazolium hydrogen sulfate
	  	1	  	100 g	  	Hood 2
	
2,2-Azobis(2-methyl-propionitrile)

	  	2	  	25 g	  	Media Room
	
2,2-dichloro-5,6-dicyano-p-benzoquinone
	  	3	  	10 g	  	FH3 oxidizers
	 2,2-Dimethoxypropane
	  	1	  	500 mL	  	Hood 4
	 2,2-Dimethoxypropane, Reagent Grade, 98%
	  	1	  	500 ml	  	FH3 Flammables
	
2,3,4,6-Tetra-O-acetyl-a-D-mannopyranosyl trichlaroacetimidate, 2 g
	  	1	  	2 g	  	Mini Fridge
	
2,3,4,6-Tetra-o-acetyl-beta-d-glucopyranosyl 2,2,2-trichloroacetimidate,
	  	1	  	5 g	  	Mini Fridge
	
2,3-di-o-benzyl-D-glucopyranose
	  	1	  	25 g	  	FH3 Flammables
	 2,4,6-Triisopropylbenzenesulfonic acid, 5g
	  	1	  	10 g	  	Hood 2 acid
	 2,5-Dihydroxybenzoic acid
	  	10	  	10 mg	  	Acid Cabinet
	 20% Palladium on Carbon in Water
	  	1	  	5 g	  	Inorganic Shelf
	 2alpha-Mannobiose
	  	1	  	10 mg	  	monomer storage
	
2-amino-4-methylthiophene-3-carboxylate
	  	1	  	5 g	  	mini fridge
	 2-Aminoacridone
	  	1	  	25 mg	  	Media Room
	 2-Aminopyridine
	  	1	  	25 g	  	Media Room
	
2-Chloro-l,3-dimethylimidazolinium
 chloride
	  	1	  	10 g	  	FH5 acids
	 2-Mesitylenesulfonic Acid Dihydrate, 97%
	  	1	  	25 g	  	hood 2 acid
	 2-Pyridinesulfonic Acid, 97%
	  	1	  	10 g	  	Hood 2 acid
	
3,3-Dimethyl-1-Butanol,
 98%
	  	1	  	10 g	  	Hood 2
	
3,3’-Methylene-Bis(4-Hydroxycoumarin)

	  	1	  	5 g	  	Mini Fridge
	 342, 1.3k, 6k, 10k, 22k, 50k, 110k, 200k, 400k, 800k
	  		  		  	monomer storage
	
3-Methyl-l-phenyl-2-pyrazoline-5-one
	  	1	  	100 g	  	Media Room
	
3-O-Benzyl-l,2-0-isopropylidene-a-D-glucofuranose

	  	1	  	25 g	  	Media Room
	 3-Pyridinesulfonic Acid, 98%
	  	1	  	5 g	  	Hood 2 acid
	 4-(Dimethylamino)pyridine
	  	1	  	25 g	  	Hood 7
	
4,6-O-Benzylidene-D-glucose
	  	1	  	50 g	  	Media Room
	 4-Nitrophenyl ß-D-galacto-pyran-oside
	  	1	  	1 g	  	Media Room
	 4-Nitrophenyl ß-D-glucopyranoside
	  	1	  	1 g	  	Media Room
	
4-O-beta-Galactopyranosyl-D-mannopyranose
	  	1	  	25 mg	  	monomer storage
	
4-O-beta-Galactopyranosyl-D-mannopyranose
	  	3	  	25 mg	  	monomer storage
	 4-Phenylbutyric Acid, 99%
	  	1	  	25 g	  	Hood 2
	 5-Fluorouracil
	  	1	  	1 g	  	Media Room
	 9-Fluorenylmethyl Chloroformate, 97%
	  	1	  	25 g	  	Mini Fridge
	 Acetic acid
	  	1	  	100 mL	  	Hood 4
	 Acetic acid, glacial, ACS, 99.7+%
	  	1	  	2L	  	Flammable Cabinet 1
	 Acetic anhydride
	  	6	  	100 mL	  	Acid Cabinet
	 Acetic anhydride
	  	3	  	100 g	  	Acid Cabinet
	 Acetic anhydride
	  	1	  	100 mL	  	Hood 7
	 Acetic Anhydride, Reagent plus, >=99%
	  	3	  	100 mL	  	big acid
	 Acetohydroxamic Acid
	  	1	  	5 g	  	Mini Fridge
	 Acetone
	  	5	  	4L	  	Fume hood 5
	 Acetonitrile
	  	3	  	100 mL	  	Flammable Cabinet 1
	 Acetonitrile
	  	1	  	4L	  	Fume hood 5
	 Acetonitrile
	  	3	  	18L	  	Flam Cab 1
	 Acetonitrile
	  	3	  	18L	  	Flam Cab 2
	 Acetonitrile
	  	2	  	4L	  	Flam Cab 3
	 Acetonitrile for HPLC, >99.9%
	  	1	  	100 ml	  	FH3 Flammables

  
 EXHIBIT 8, PAGE 2 

							
	 Acetyl chloride
	  	1	  	500 g	  	Hood 4
	 Activated charcoal
	  	1	  	250 g	  	Inorganic Shelf
	
A-D-Mannosepentaacetate
	  	1	  	5 g	  	Mini Fridge
	 Alcian Blue solution
	  	1	  	250 mL	  	Media Room
	 Allopurinol
	  	1	  	5 g	  	Hood 2
	 allylbromide
	  	1	  	25 g	  	mini fridge
	 Alpha-D-Glucose
Penta Acetate, 99%
	  	1	  	25 g	  	Mini Fridge
	 Amberlyst 15 hydrogen form
	  	1	  	25 g	  	Media Room
	 Ammonium acetate
	  	1	  	500 g	  	Media Room
	 Ammonium formate
	  	1	  	500 g	  	Inorganic Shelf
	 Ammonium formate
	  	1	  	100 g	  	Media Room
	 Ammonium molybdate tetrahydrate
	  	1	  	100 g	  	Media Room
	 ammonium molybdate tetrahydrate, ACS reagent, >99%
	  	1	  	100 g	  	FH3 oxidizers
	 Ampicilin
	  	1	  	25 g	  	Media Room
	 Anthranilic acid
	  	1	  	25 g	  	Media Room
	 Aspartame
	  	1	  	1 g	  	Media Room
	 Aspartame
	  	1	  	1 g	  	Media Room
	 Barium hydroxide
	  	1	  	250 g	  	Inorganic Shelf
	 Barium oxide
	  	1	  	50 g	  	Inorganic Shelf
	 Benzaldehyde
	  	1	  	100 g	  	Hood 4
	 Benzaldehyde dimethyl acetal
	  	1	  	100 g	  	FH3 Flammables
	 Benzoyl chloride
	  	1	  	100 mL	  	Hood 7
	 Benzyl Bromide, Reagent Grade, 98%
	  	1	  	100 g	  	FH3 Flammables
	 Benzylamine, Reagentplus, 99%
	  	1	  	100 g	  	FH5 Bases
	 Biotin
	  	1	  	100 mg	  	Media Room
	 bis(tributyltin) oxide
	  	1	  	100 g	  	hood 2
	 Borane THF complex solution, 1M
	  	1	  	100 ml	  	FH3 Flammables
	 Boron Trifluoride Diethyl Etherate
	  	2	  	100 mL	  	Mini Fridge
	 Boron Trifluoride Diethyl Etherate
	  	4	  	25 mL	  	Mini Fridge
	 Bromophenol Blue
	  	1	  	5 g	  	Media Room
	 Butane
	  		  		  	Media Room
	 Butyric Anhydride, 98%
	  	1	  	1000 mL	  	Hood 2 acid
	
Camphor-10-Sulfonic Acid (Beta),
98%
	  	1	  	5 g	  	Hood 2 acid
	 Carbon
	  	1	  	500 g	  	monomer storage
	 Carbon Tetrachloride, Reagent Grade, 99.
	  	1	  	1 L	  	FH3 Flammables
	 Carbon, Darco G-60, Activated, Fisher Chemical
	  	1	  	500 g	  	Inorganic Shelf
	 Cefoxitin sodium salt
	  	1	  	1 g	  	Media Room
	 Celite
	  	1	  	1 kg	  	Inorganic Shelf
	 Celite 545
	  	1	  	500 g	  	monomer storage
	 Celite® 545
	  	1	  	500 g	  	Inorganic Shelf
	 Cellulose microcrystalline
	  	1	  	1 Kg	  	monomer storage
	 Cerium(iv) sulfate
	  	1	  	25 g	  	FH3 oxidizers
	 Cerium(IV) sulfate
	  	1	  	25 g	  	Media Room
	 Chloroform-d
	  	1	  	100 g	  	Hood 4
	 Chloromethyl Methyl Ether Tech
	  	1	  	25 g	  	Mini Fridge
	 Chlorotrimethylsilane
	  	4	  	100 mL	  	Acid Cabinet
	 Chondroitin sulfate A sodium salt
	  	1	  	5 g	  	monomer storage
	 Ciprofloxacin
	  	1	  	5 g	  	Media Room
	 Ciprofloxacin Hydrochloride
	  	1	  	100 mg	  	Mini Fridge
	 Citric acid
	  	1	  	100 g	  	Media Room
	 Citric Acid Anhydrous (Crystalline/Certified ACS), Fisher Chemical
	  	1	  	500 g	  	Inorganic Shelf
	 Colistin sulfate salt
	  	1	  	1 g	  	Media Room
	 Copper(II) sulfate
	  	1	  	500 g	  	Inorganic Shelf
	 Copper(II) sulfate pentahydrate, 99+%, for analysis
	  	1	  	1KG	  	Inorganic Shelf
	 cyanocobalamine
	  	1	  	1 g	  	Media Room
	 Cyclohexane
	  	2	  	4L	  	Flam Cab 1
	 D(-)-Arabinose
	  	1	  	100 g	  	monomer storage
	 D(-)-Arabinose
	  	1	  	100 g	  	monomer storage
	 D-(-)-Arabinose
	  	2	  	100 g	  	monomer storage
	 D-(-)-Ribose
	  	1	  	100 g	  	monomer storage
	 D(+)-Cellobiose
	  	1	  	100 g	  	Media Room
	 D-(+)-Cellobiose
	  	1	  	25 g	  	monomer storage
	 D-(+)-Galactose
	  	1	  	1 Kg	  	monomer storage
	 D-(+)-Maltose monohydrate
	  	1	  	500 g	  	monomer storage
	 D-(+)-Turanose
	  	1	  	1 g	  	monomer storage

  
 EXHIBIT 8, PAGE 3 

							
	 D-(+)-Xylose
	  	1	  	500 g	  	monomer storage
	 D-(+)-Xylose
	  	2	  	1 Kg	  	monomer storage
	 D-(+)-Xylose
	  	1	  	1 Kg	  	monomer storage
	 D-(+)-Xylose
	  	1	  	5 Kg	  	monomer storage
	 Daptomycin, Cyclic Lipopeptide Antibiot
	  	1	  	100 mg	  	Mini Fridge
	 DCM
	  	2	  	4L	  	Flam Cab 5
	 Deuterium oxide
	  	2	  	100 g	  	Hood 4
	 Dextrose
	  	1	  	1 Kg	  	monomer storage
	 D-Galacturonic acid monohydrate
	  	1	  	100 g	  	monomer storage
	 D-Glucal
	  	1	  	25 g	  	Media Room
	 D-Glucoronic acid
	  	1	  	100 g	  	monomer storage
	 D-Glucosamine HCl
	  	1	  	500 g	  	monomer storage
	 D-Glucose(U13C6)
	  	1	  	5 g	  	monomer storage
	 Dibutyltin Oxide, 98%
	  	1	  	100 g	  	Hood 2
	 Dichloromethane
	  	2	  	100 mL	  	Flammable Cabinet 1
	 Diethyl Ether
	  	4	  	1L	  	Flam Cab 2
	 Diethyl Ether, Contains 1 Ppm Bht As In
	  	1	  	1L	  	FH3 Flammables
	 Dimethyl sulfoxide
	  	1	  	100 ml	  	monomer storage
	 Dimethylsulphoxide, hybri-max
	  	1	  	100 ml	  	FH3 Flammables
	 D-Lactose monohydrate
	  	1	  	1 kg	  	Media Room
	 D-Lactose monohydrate
	  	1	  	1 Kg	  	monomer storage
	 D-Mannitol
	  	1	  	250 g	  	monomer storage
	 D-Mannose
	  	1	  	1 Kg	  	monomer storage
	 DMF
	  	1	  	4L	  	Flam Cab 1
	 DMF
	  	3	  	2L	  	Flam Cab 3
	 DMSO
	  	4	  	4L	  	Flam Cab 3
	 DMSO
	  	1	  	4L	  	Flam Cab 5
	 Dowex® 50WX8 hydrogen form
	  	1	  	500 g	  	Inorganic Shelf
	 Dowex®
MAC-3 hydrogen form
	  	1	  	250 g	  	Hood 4
	 Dowex® MarathonTM MSC hydrogen
form
	  	1	  	100 g	  	Inorganic Shelf
	 Drierite® Indicating
	  	1	  	2.5000 kg	  	Inorganic Shelf
	 D-Sorbitol
	  	1	  	500 g	  	monomer storage
	 Ethanol
	  	5	  	4L	  	Fume Hood 7
	 Ethidium bromide in water
	  	1	  	10 mL	  	Media Room
	 Ethyl acetate
	  	1	  	4L	  	Media Room
	 Ethylene glycol
	  	4	  	2L	  	Media Room
	 Ethylene Glycol
	  	2	  	4L	  	Flam Cab 5
	 EtOAc
	  	5	  	4L	  	Fume Hood 6
	 Fe(dibm)3
	  	7	  	100 mg	  	Inorganic Shelf
	 Febuxostat
	  	1	  	1 g	  	Hood 2
	 Fmoc chloride
	  	1	  	5 g	  	Acid Cabinet
	 Fructose
	  	2	  	500 g	  	monomer storage
	 Furosemide
	  	1	  	5 g	  	Hood 2
	 Gentamicin sulfate
	  	1	  	5 g	  	Media Room
	 Glycerol
	  	1	  	100 ml	  	Media Room
	 Glycogen from bovine liver
	  	1	  	1 g	  	monomer storage
	 GlycoProfile 2-AB Labeling kit, including
	  	1	  		  	Media Room
	 Heptane
	  	8	  	4L	  	Fume Hood 6
	 Hexyl Alcohol, Reagent Grade, 98%
	  	1	  	100 ML	  	Hood 2
	 hydrazine monohydrate, reagent grade, 98%
	  	1	  	100 g	  	FH5 Bases
	 Hydrobromic acid solution
	  	1	  	50 mL	  	Acid Cabinet
	 Hydrochloric Acid (Technical), Fisher Chemical
	  	2	  	2.5 L	  	Acid Cabinet
	 Hydrocinnamoyl Chloride, 98%
	  	1	  	25 G	  	Hood 2
	 Hydrogen Chloride CA. 3 M IN 1-Butanol
	  	1	  	50 mL	  	Mini Fridge
	 Imidazole
	  	1	  	500 g	  	Hood 4
	 imidazole
	  	1	  	100 g	  	Media Room
	 Imidazole, ACS reagent, >99%
	  	1	  	100 g	  	FH5 Bases
	 Iodine
	  	1	  	100 g	  	Inorganic Shelf
	 IPA
	  	4	  	4L	  	Flam Cab 2
	 IPA
	  	1	  	4L	  	Flam Cab 3
	 Iron(III) acetylacetonate
	  	1	  	50 g	  	Inorganic Shelf
	 Kanamycin sulfate
	  	1	  	25 g	  	Media Room
	 L-(+)-Arabinose
	  	1	  	1 Kg	  	monomer storage
	 L-(+)-Arabinose
	  	1	  	1 Kg	  	monomer storage
	 Lactulose
	  	1	  	100 g	  	monomer storage

  
 EXHIBIT 8, PAGE 4 

							
	L-Cysteine hydrochloride monohydrate	  	1	  	100 g	  	Media Room
	L-Cysteine hydrochloride monohydrate	  	1	  	100 g	  	Media Room
	Levan from erwinia herbicola	  	1	  	1 g	  	monomer storage
	L-Fucose	  	3	  	100 g	  	monomer storage
	L-Fucose	  	3	  	100 g	  	monomer storage
	L-Histidine hydrochloride monohydrate	  	1	  	100 g	  	Media Room
	Lithium aluminum hydride solution	  	1	  	800 mL	  	Hood 4
	L-Rhamnose	  	1	  	1 Kg	  	monomer storage
	Maltodextrin DE13-17	  	1	  	100 g	  	monomer storage
	Maltodextrin DE16.5-19.5	  	1	  	100 g	  	monomer storage
	Maltodextrin DE4-7	  	1	  	500 g	  	monomer storage
	Maltodextrin DE4-7	  	1	  	100 g	  	monomer storage
	Maltoheptaose	  	1	  	1 g	  	monomer storage
	Maltohexaose	  	1	  	100 mg	  	monomer storage
	Maltooctaose	  	1	  	100 mg	  	monomer storage
	Maltopentaose	  	1	  	50 mg	  	monomer storage
	Maltotetraose	  	1	  	50 mg	  	monomer storage
	Maltotriose	  	1	  	1 g	  	monomer storage
	Mannan from saccharomyces cerevisiae	  	1	  	100 mg	  	monomer storage
	Melibiose	  	1	  	5 g	  	monomer storage
	MeOH	  	4	  	4L	  	Flam Cab 2
	methyl a-d-mannopyranoside	  	1	  	5 g	  	mini fridge
	Methylamine, 2.0 solution in Tetrahydr	  	1	  	100 ml	  	FH5 Bases
	Metronidazole	  	1	  	25 g	  	Media Room
	Molecular sieves, 4 A	  	1	  	1 kg	  	Inorganic Shelf
	MTBE	  	10	  	4L	  	Flam Cab 2
	M-xylene, Anhydrous, >=99%	  	1	  	100 ml	  	FH3 Flammables
	N-(1-Naphthyl) Ethylenediamine	  	1	  	10 g	  	Hood 2
	N,N-Diisopropylethylamine, Reagentplus	  	5	  	100 ml	  	FH5 Bases
	N,N-Dimethylformamide	  	3	  	100 mL	  	Flammable Cabinet 1
	N,N-Dimethylformamide, Anhydrous	  	1	  	100 ml	  	FH3 Flammables
	N-Acetyl-D-galactosamine	  	1	  	100 mg	  	monomer storage
	N-Acetyl-D-glucosamine	  	1	  	5 g	  	monomer storage
	N-Acetylneuraminic acid	  	1	  	100 g	  	monomer storage
	Naphthalene-1,5-disulfonic acid, 5g	  	1	  	5 g	  	hood 2 acid
	N-Carbamyl-L-Glutamic Acid Crystalline	  	1	  	10 g	  	Hood 2
	Neomycin sulfate	  		  	1 g	  	Media Room
	N-lodosuccinimide, 95%	  	1	  	5 g	  	Mini Fridge
	N-lodosuccinimide, 95%	  	2	  	25 g	  	Mini Fridge
	Oxalyl Chloride, 2.0M Solution IN	  	1	  	100 mL	  	Mini Fridge
	Oxalyl Chloride, Reagent Grade, 98%	  	1	  	25 g	  	Mini Fridge
	Oxipurinol	  	1	  	1 g	  	Hood 2
	OXONE, monopersulfate compound	  	1	  	100 g	  	FH3 oxidizers
	OXONE, monopersulfate compound	  	1	  	100 g	  	Media Room
	Palladium on carbon	  	3	  	10 g	  	Inorganic Shelf
	Palladium on carbon	  	1	  	10 g	  	Media Room
	p-anisaldehyde, 98%	  	1	  	100 g	  	FH3 Flammables
	Pectin from citrus peel	  	1	  	1 KG	  	monomer storage
	Phenol Bioxtra	  	1	  	100 g	  	Mini Fridge
	Phenol, for molecuklar biology	  	1	  	100 g	  	FH5 acids
	Phenol, unstabilized, reagentplus >99%	  	1	  	500 g	  	FH5 acids
	Phenylboronic acid—250 grams	  	1	  	250 g	  	FH5 acids
	Phosphorus(V) oxychloride	  	2	  	5 g	  	Acid Cabinet
	picric acid	  	1	  	100 g	  	biology lab
	Pinacol, 500 g bottle	  	1	  	500 g	  	FH5 acids
	Pinacol, 98%	  	1	  	100 g	  	FH5 acids
	Poly(vinyl alcohol)	  	2	  	250 g	  	Inorganic Shelf
	Poly(vinyl alcohol)	  	2	  	250 g	  	Media Room
	Potassium Chloride solution, 0.01M	  	1	  	250 ml	  	Media Room
	Potassium Chloride, 0.01 M	  	1	  	500 ml	  	monomer storage
	Potassium Hydroxide	  	1	  	1 kg	  	Inorganic shelf
	Potassium iodide	  	1	  	100 g	  	Inorganic Shelf
	p-toluenesulfonic acid, monohydrate	  	1	  	100 g	  	Hood 2 acid
	Pullulan from aureobasidium pullulans	  	1	  	1 g	  	monomer storage
	Pullulan Standard Set	  	1	  	100 mg each	  	monomer storage

  
 EXHIBIT 8, PAGE 5 

							
	 Pullulan Standard, 12k
	  	1	  	25 mg	  	monomer storage
	 Pullulan Standard, 1300
	  	1	  	25 mg	  	monomer storage
	 Pullulan Standard, 6k
	  	1	  	25 mg	  	monomer storage
	 Pyrazine, 99+%
	  	1	  	5 g	  	Hood 2
	 Pyridine
	  	1	  	100 mL	  	Hood 7
	 Pyridine
	  	5	  	100 mL	  	Media Room
	 Pyruvic Acid, 98%
	  	1	  	25 g	  	Mini Fridge
	 Quercetin
	  	1	  	1 g	  	Mini Fridge
	 Rifaximin
	  	1	  	1 g	  	Media Room
	 Rutinose
	  	1	  	25 mg	  	monomer storage
	 Sand
	  	1	  	1KG	  	Media Room
	 Silica gel
	  	1	  	5 KG	  	Media Room
	 Silver carbonate
	  	1	  	25 g	  	Inorganic Shelf
	 Silver(I) oxide
	  	1	  	10 g	  	Inorganic Shelf
	 Sodium acetate
	  	1	  	100 g	  	Inorganic Shelf
	 Sodium acetate buffer solution
	  	1	  	500 mL	  	Media Room
	 Sodium azide
	  	1	  	100 g	  	Media Room
	 Sodium bicarbonate
	  	1	  	1 KG	  	Media Room
	 Sodium bisulfite
	  	1	  	1 kg	  	Inorganic Shelf
	 Sodium Borohydride Fine Granular for Syn
	  	1	  	25 g	  	Hood 2
	 Sodium cyanoborohydride, 1M in THF
	  	1	  	100 ml	  	Media Room
	 Sodium hydride
	  	1	  	100 g	  	Media Room
	 Sodium Hydroxide
	  	1	  	1 kg	  	Inorganic Shelf
	 Sodium Hydroxide, ACS
	  	1	  	500 g	  	Inorganic Shelf
	 Sodium iodide
	  	1	  	100 g	  	Inorganic Shelf
	 Sodium metaperiodate—500 grams
	  	2	  	500 g	  	FH3 oxidizers
	 Sodium methoxide
	  	1	  	100 g	  	Media Room
	 Sodium methoxide solution
	  	1	  	100 mL	  	Hood 4
	 Sodium nitrate
	  	1	  	250 g	  	Media Room
	 Sodium Nitrate
	  	1	  	1 Kg	  	monomer storage
	 Sodium Nitroprusside
	  	1	  	100 mg	  	Mini Fridge
	 Sodium silica gel Stage I
	  	1	  	25 g	  	Inorganic Shelf
	 Sodium sulfate
	  	1	  	500 g	  	Media Room
	 Styrene
	  	2	  	100 mL	  	Media Room
	 Sucralose
	  	1	  	100 g	  	monomer storage
	 Sucrose
	  	1	  	500 g	  	monomer storage
	 Sucrose
	  	1	  	500 g	  	monomer storage
	 Sulfolane, 99%
	  	1	  	100 g	  	FH3 Flammables
	 Sulfuric Acid (Technical), Fisher Chemical
	  	1	  	2.5 L	  	Acid Cabinet
	 TBE running buffer
	  	1	  	1 L	  	Media Room
	 tert-Butanol
	  	1	  	500 ml	  	Media Room
	 tert-Butyl methyl ether
	  	1	  	2 L	  	Hood 4
	 tert-Butyl(chloro)diphenylsilane
	  	1	  	250 g	  	Acid Cabinet
	 tert-Butyl(chloro)diphenylsilane
	  	1	  	50 g	  	Hood 4
	 tert-Butyl(chloro)diphenylsilane
	  	1	  	50 g	  	Media Room
	 tert-Butylchlorodiphenylsilane, 98%
	  	2	  	50GR	  	Hood 4
	 Tetrabutylammonium bromide
	  	1	  	100 g	  	Inorganic Shelf
	 Tetrabutylammonium iodide, 98%
	  	1	  	100GR	  	Inorganic Shelf
	 Tetrahydrofuran, Anhydrous, >=99.9%
	  	1	  	100 ml	  	FH3 Flammables
	 THF 
	  	2	  	1L	  	Flam Cab 1
	 THF
	  	3	  	4L	  	Flam Cab 3
	 Thiourea Acs Reagent
	  	1	  	50 g	  	Mini Fridge
	 tin (IV) chloride
	  	1	  	25 g	  	acid cabinet
	 Tin(IV) chloride
	  	1	  	25 g	  	Acid Cabinet
	 Toluene
	  	3	  	1L	  	Flam Cab 1
	 Toluene, ACS, 99.5%
	  	1	  	1 L	  	FH3 Flammables
	 Toluene, anhydrous, 99.8%
	  	1	  	100 ml	  	FH3 Flammables
	 Tributyrin
	  	4	  	1 KG	  	Media Room
	 Triethylamine, >=99.5%
	  	1	  	500 ml	  	FH5 Bases
	 Triethylamine, high purity
	  	3	  	100 ml	  	FH5 bases
	 Triethylsilane
	  	1	  	100 g	  	Flammable Cabinet 1
	 Trifluoroacetic acid
	  	4	  	100 mL	  	Acid Cabinet
	 Trifluoroacetic acid
	  	10	  	1 mL	  	Acid Cabinet
	 Trifluoroacetic acid
	  	2	  	50 mL	  	Acid Cabinet
	 Trimethyl phosphate
	  	2	  	50 g	  	Media Room

  
 EXHIBIT 8, PAGE 6 

							
	 Trimethylacetyl chloride
	  	1	  	500 mL	  	Hood 4
	 Trimethylsilyl trifluoromethanesulfonate
	  	1	  	10 mL	  	Hood 4
	 Trityl chloride
	  	2	  	100 g	  	Acid Cabinet
	 Trityl Chloride, 97%
	  	1	  	100 g	  	FH3 Flammables
	 Vinylbenzyl chloride
	  	1	  	100 mL	  	Media Room
	 Water
	  	5	  	4L	  	Flam Cab 3
	 Xylobiose
	  	1	  	10 mg	  	monomer storage

  
 EXHIBIT 8, PAGE 7 

 EXHIBIT 9-1 

BUILDING RULES AND REGULATIONS 

65 HAYDEN AVENUE, LEXINGTON, MA 
  

	A.	 General 

1. Tenant and its employees shall not in any way obstruct the sidewalks, halls, stairways, or exterior vestibules of the Building, and shall
use the same only as a means of passage to and from their respective offices. At no time shall Tenants permit its employees, contractors, or other representatives to loiter in Common Areas or elsewhere in and about the Property. 

2. Corridor doors, when not in use, shall be kept closed. 

3. Areas used in common by tenants shall be subject to such regulations as are posted therein. 

4. Any Tenant or vendor sponsored activity or event in the Common Area must be approved and scheduled through Landlord’s representative,
which approval shall not be unreasonably withheld. 
 5. No animals, except Seeing Eye dogs, shall be brought into or kept in, on or about
the Premises or Common Areas, except as approved by Landlord. 
 6. Alcoholic beverages (without Landlord’s prior written consent),
illegal drugs or other illegal controlled substances are not permitted in the Common Areas, nor will any person under the influence of the same be permitted in the Common Areas. Landlord reserves the right to exclude or expel from the Building any
persons who, in the judgment of the Landlord, is under the influence of alcohol or drugs, or shall do any act in violation of the rules and regulations of the Building. 

7. No firearms or other weapons are permitted in the Common Areas. 

8. No fighting or “horseplay” will be tolerated at any time in the Common Areas. 

9. Tenant shall not cause any unnecessary janitorial labor or services in the Common Areas by reason of Tenant’s carelessness or
indifference in the preservation of good order and cleanliness. 
 10. Smoking and discarding of smoking materials by Tenant and/or any
Tenant Party is permitted only in exterior locations designated by Landlord. Tenant will instruct and notify its employees and visitors of such policy. 

11. Bicycles and other vehicles are not permitted inside or on the walkways outside the Building, except in those areas specifically
designated by Landlord for such purposes 
 12. Tenant shall not operate or permit to be operated on the Premises any coin or token operated
vending machine or similar device (including, without limitation, telephones, lockers, toilets, scales, amusement devices and machines for sale of beverages food, candy, cigarettes or other goods), except for those vending machines or similar
devices which are for the sole and exclusive use of tenant’s employees and located within the Tenant Premises. 

  
 EXHIBIT 9-1, PAGE 1 

 13. Canvassing, soliciting, and peddling in or about the Building is prohibited. Tenant, its
employees, agents and contractors shall cooperate with said policy, and Tenant shall cooperate and use best efforts to prevent the same by Tenant’s invitees. 

14. Fire protection and prevention practices implemented by the Landlord from time to time in the Common Areas, including participation in
fire drills, must be observed by Tenant at all times. 
 15. Except as provided for in the Lease, no signs, advertisements or notices shall
be painted or affixed on or to any windows, doors or other parts of the Building that are visible from the exterior of the Building unless approved in writing by the Landlord. 

16. The restroom fixtures shall be used only for the purpose for which they were constructed and no rubbish, ashes, or other substances of any
kind shall be thrown into them. Tenant will bear the expense of any damage resulting from misuse. 
 17. Tenant will not interfere with or
obstruct any building central HVAC, electrical, or plumbing systems. 
 18. Tenant shall utilize the pest control service designated by
Landlord to control pests in the Premises. Except as included in Landlord’s Services, tenants shall bear the cost and expense of such pest control services. 

19. Tenant shall not install, operate or maintain in the Premises or in any other area of the Building, any electrical equipment which does
not bear the U/L (Underwriters Laboratories) seal of approval, or which would overload the electrical system or any part thereof beyond its capacity for proper, efficient and safe operation as determined by Landlord, taking into consideration the
overall electrical system and the present and future requirements of the Building. 
 20. Tenants shall not use more than its proportionate
share of telephone lines available to service the Building. 
 21. Tenants shall not perform improvements or alterations within the Building
or their Premises, if the work has the potential of disturbing the fireproofing which has been applied on the surfaces of structural steel members, without the prior written consent of Landlord, subject to the provisions of the Lease. 

22. Tenant shall manage its waste removal and janitorial program, at its sole cost and expense, keeping any recyclables, garbage, trash,
rubbish and refuse in vermin proof containers for Tenants sole use within the Landlord designated area until removed with all work to be performed during non-business hours. 

23. Lab operators who travel outside lab space must abide by the one glove rule and remove lab coats where predetermined. 

  
 EXHIBIT 9-1, PAGE 2 

 24. Chemical lists and MSDS sheets must be readily available at the entrance to each lab
area. In the event of an emergency, first responders will require this information in order to properly evaluate the situation. 
 25.
Tenant shall provide Landlord, in writing, the names and contact information of two (2) representatives authorized by Tenant to request Landlord services, either billable or non-billable and to act as a
liaison for matters related to the Premises. 
 26. Parking of any trailers, trucks, motor homes, or unregistered vehicles in the parking
lots is prohibited. 
 27. Tenants shall not use more than its proportionate share of Base Building Central HVAC or electrical capacity,
subject to the provisions of the lease. 
  

	B.	 Access & Security 

1. Landlord reserves the right to close and keep locked all entrance and exit doors of the Building during the hours Landlord may deem
advisable for the adequate protection of the Property. Use of the Building and the leased premises before 8 AM or after 6 PM, or any time during Saturdays, Sundays or legal holidays shall be allowed only to persons with a key/card key to the
Building or guests accompanied by such persons. Any persons found in the Building after hours without such keys/card keys are subject to the surveillance of building staff. 

2. Tenant shall not place any additional lock or locks on any exterior door in the Premises or Building or on any door in the Building core
within the Premises, including doors providing access to the telephone and electric closets and the slop sink, without Landlord’s prior written consent. A reasonable number of keys to the locks on the doors in the Premises shall be furnished by
Landlord to Tenant at the cost of Tenant, and Tenant shall not have any duplicate keys made. All keys shall be returned to landlord at the expiration or earlier termination of this Lease. 

3. Landlord may from time to time adopt appropriate systems and procedures for the security or safety of the Building, its occupants, entry
and use, or its contents, provided that Tenant shall have access to the Building 24 hours per day, 7 days a week. Tenant, Tenant’s agents, employees, contractors, guests and invitees shall comply with Landlord’s reasonable requirements
relative thereto. 
 4. Tenant acknowledges that Property security problems may occur which may require the employment of extreme security
measures in the day-to-day operation of the Common Areas. Accordingly, Tenant agrees to cooperate and cause its employees, contractors, and other representatives to
cooperate fully with Landlord in the implementation of any reasonable security procedures concerning the Common Areas. 
 5. Tenant and its
employees, agents, contractors, invitees and licensees are limited to the Premises and the Common Areas. Tenants and its employees, agents, contractors, invitees and licensees may not enter other areas of the Project (other than the Common Areas)
except when accompanied by an escort from the Landlord. 

  
 EXHIBIT 9-1, PAGE 3 

	C.	 Shipping/Receiving 

1. Dock areas for the Building shall not be used for storage or staging by Tenant except in the Loading Dock Premises as permitted in the
Lease. 
 2. In no case shall any truck or trailer be permitted to remain in a loading dock area for more than 60 minutes, except with prior
written notice to Landlord, which notice may be given via email, provided that, in any event Landlord shall have the right, in good faith, to require Tenant to adjust its schedule for the use of the dock areas based upon the needs of the other
tenants of the Building and Building operations. 
 3. There shall not be used in any Common Area, either by Tenant or by delivery personnel
or others, in the delivery or receipt of merchandise, any hand trucks, except those equipped with rubber tires and sole guards. 
 4. Lab
operators carrying any lab related materials may only travel within the Premises. At no time should any lab materials travel in the Common Areas, except at the Loading Dock and Freight Elevator. 

5. Any dry ice brought into the building must be delivered through the loading dock. 

6. All nitrogen tanks must travel through the loading dock and should never be left unattended outside of the Premises. 

  
 EXHIBIT 9-1, PAGE 4 

 EXHIBIT 9-2 

TENANT CONSTRUCTION 

LINCOLN PROPERTY COMPANY 

TENANT CONSTRUCTION 

BUILDING RULES AND REGULATIONS 

THE RULES MUST BE POSTED AT THE JOB SITE AT ALL TIMES! 
  

	1.	 Parking. Parking areas are designated by the Management Office and are subject to change at any time.
Construction personnel are required to park in the parking areas designated by the management office. Failure to adhere to this regulation will result in the towing of the vehicle in violation at the owner’s expense. 

 

	2.	 Access. Building entrances; lobbies, passages, corridors, public elevators, stairways, and other common
areas may not be encumbered, or obstructed by the contractor, or contractor’s agents during construction of the tenant’s lease premises. Material deliveries must be scheduled in advance through the Management Office and coordinated with
the Lincoln Property Company representative. Contractors are not to use Tenant phones, or Restrooms under any circumstances. Construction personnel found using phones, or restrooms located in the tenant’s suite will be asked to immediately
leave the premises and will not be allowed to return. 

  

	3.	 Each contractor is responsible for their subcontractor(s), and for the actions of their personnel including clean-up of work and construction traffic. No alcoholic beverages, glass containers, or “controlled substances” are allowed on the premises. All work must be scheduled through the Management Office and
include a list of contractors performing work prior to the start of the work. After hours work must be scheduled through the Management Office 24 Hours before the activity will occur. Weekend activity must be scheduled by Friday at 9 a.m.
Contractors will not be allowed to work in the building after hours, or on weekends unless the procedures outlined above have been followed. 

All after hours work must be supervised by the general contractor. There will be no exceptions to this rule. 

Prior to the commencement and upon completion of each job, a walk-through of public areas will be made, i.e. restrooms, etc., and any
subsequent damages will be the responsibility of the contractor. The contractor shall be responsible for cleaning the assigned restrooms each day at his own expense. 
  

	4.	 Noise and Vapor Restrictions. Any work that would cause inconvenience to other tenants in the building,
or that must be done in an occupied space must be done after hours or on the weekend. Structural modifications, floor penetrations created with the use of core drilling machines, pneumatic hammers, etc., shall be performed before 7:30 a.m. or after
7:00 p.m. Likewise, any construction operations causing excessive noise, dust, vapors must be conducted during these hours. 

  
 EXHIBIT 9-2, PAGE 1 

 When construction is on an occupied multi-tenant floor, noise i.e., radios, loud talking,
noise from equipment, etc. must be kept to a minimum. On these multi-tenant floors, public restrooms are not to be used by contractors. 
 A
Lincoln Property Company superintendent, or the Property Manager will have the sole authority to determine if an operation is causing excessive noise, dust, or vapors. 
  

	5.	 Lincoln Property Company has the right to inspect work at any time and may reject work that does not conform to
code, tenant’s plans, or work that may affect the exterior appearance, structural components, or service system of the building. 

  

	6.	 Mechanical and electrical shop drawings must be reviewed and approved by Landlord’s approved engineer.
Prior to starting work, the general, mechanical, and electrical contractors must review the work with the Facilities Manager and Facilities Supervisor. 

All panels and transformers are to match the building standard systems and all materials and methods used to connect panels and transformers
must be approved by Landlord. 
 Unscheduled outages of any utility, or building service is strictly prohibited. 

 

	7.	 Dust and air contamination are to be controlled with temporary partitions which are sealed adequately to
prevent dust from entering leased areas or mechanical equipment. Floor sweep or a comparable material will be used when sweeping concrete or tile floors. 

  

	8.	 Clean-up of Common and Lease Areas. Premises must be kept in a
clean, orderly fashion at all times and free of potential safety and fire hazards. A general clean-up of the space under construction is to be performed on a daily basis. Final
clean-up will be the responsibility of the contractor, which is to include all vacuuming and dusting as required. Failure to adequately keep the work area clean and accessible will result in Lincoln Property
Company using its own forces to achieve this through whatever means determined necessary and the total cost will be deducted from the contract. 

  

	9.	 Trash Removal. Contractor is responsible for removing all construction debris and trash from the
construction site. UNDER NO circumstances shall trash, or construction debris be allowed to accumulate. Trash removal must be coordinated through the Lincoln Property Company Management Office. No vehicles, or dumpsters will be allowed to
remain stationary on the site. 

  
 EXHIBIT 9-2, PAGE 2 

 Under no circumstances is the Landlord’s dumpster to be used. 

 

	10.	 If any fire sprinkler work, or modification to the fire sprinkler system is required, the system must be back
in operation at the end of the work day. Under no circumstances shall the fire sprinkler system be left inoperative overnight. The facilities manager must be notified each morning of the location of and type of sprinkler work to be performed. The
engineer hourly rate of $75.00 will be charged for routine work and/or extended regular hour work. 

  

	11.	 Existing pull stations and horns and strobes located throughout the building will remain live during
construction. 

  

	12.	 All construction staging, storage, and temporary contractor facilities will be located in specific areas
assigned by the Lincoln Property Company. Contractors will be responsible for the maintenance, housekeeping, and demolition of all temporary facilities. 

  

	13.	 Any removal, replacement, or repair work to a base building system to accommodate work directed by the tenant,
or unforeseen interference (i.e., sprinkler head conflicts) which is not part of the Work, will be performed by the tenant’s contractor at tenant’s sole expense. 

 

	14.	 No fire arms or weapons are permitted on the property. 

 

	15.	 Insurance. Contractors will be required to carry standard requirements incorporating both the owner and LPC
Commercial Services, Inc. as additionally insured parties. 

  

	16.	 At no time is any welding, or cutting with a torch to be used in the building without prior approval and
coordination from the Management Office. Hot work permits may be required depending on the status of the project for all hot work including welding, soldering, and torch cutting. All hot work requires a fire extinguisher supplied by the contractor
and must be in the immediate vicinity and easily accessible. Fire extinguishers must be inspected at lease monthly. 

  

	17.	 A copy of these regulations shall be posted on the job site for all parties to observe. Contractor is
responsible for instructing all of his personnel, subcontractors and supplies to comply with these regulations. 

  

	18.	 ALL PASSENGER ELEVATORS AND PUBLIC AREAS SHALL BE RESTRICTED AND OFF LIMITS TO ALL CONSTRUCTION
PERSONNEL. Under no circumstances shall the exit stairwells be used for access to/from the first floor. All construction personnel for this project shall only use the freight elevator from the first floor back lobby. Under no circumstances shall
the main entrance to the building or the garage passenger elevators be used for access. 

  
 EXHIBIT 9-2, PAGE 3 

 All deliveries of materials and equipment must be scheduled at least twenty-four
(24) hours prior to their delivery through the Lincoln Property Company Management Office. The contractor will be provided access to the freight elevator to be used in the “independent mode” for after-hours deliveries. The
Contractor shall provide an operator during work hours to ensure correct and safe usage. Contractor shall keep the elevator cab and door tracks clean and free of all debris. Contractor shall be responsible for repair costs incurred due to misuse or
damage caused by his forces. All major deliveries must be made between the hours of 11:00 pm to 7:00 a.m. Monday through Friday and all day long on Saturday and Sunday. Contractor will be charged for having an engineer on duty to assist with
deliveries when the loading dock is closed. Additional charges incurred due to non-standard elevator use (i.e., moving freight on top of elevator cab) shall be paid by the General Contractor. 

Your signature below signifies that you have read the rules above and agree to abide by all of them. 

 

									
	 	 		 	 	  		 	 

									
	Signature	 		 	Date	  		 	Firm Name

 Effective Date:______________________ 

  
 EXHIBIT 9-2, PAGE 4 

 EXHIBIT 10 

TENANT WORK INSURANCE SCHEDULE 

Tenant shall, at its own expense, maintain and keep in force, or cause to be maintained and kept in force by any general contractors, sub-contractors or other third party entities where required by contract, throughout any period of alterations to the Premises or the Building by Tenant, the following insurance coverages: 

(1) Property Insurance. “All-Risk” or “Special” Form property insurance,
and/or Builders Risk coverage for major renovation projects, including, without limitation, coverage for fire; boiler and machinery (if applicable); sprinkler damage; vandalism; malicious mischief coverage on all equipment, furniture, fixtures,
fittings, tenants work, improvements and betterments, business income, extra expense, merchandise, inventory/stock, contents, and personal property located on or in the Premises. Such insurance shall be in an amount equal to the full replacement
cost of the aggregate of the foregoing and shall provide coverage comparable to the coverage in the standard ISO “All-Risk” or “Special” form, when such coverage is supplemented with the
coverages required above. Property policy shall also include coverage for Plate Glass, where required by written contract. 
 Builders Risk
insurance coverage may be provided by the general contractor on a blanket builders risk policy with limits adequate for the project, and evidencing the additional insureds as required in the Lease. 

(2) Liability Insurance. General Liability, Umbrella/Excess Liability, Workers Compensation and Auto Liability coverage as follows:

  

			
	 (a)   General Liability
	  	$1,000,000 per occurrence
		  	$1,000,000 personal & advertising injury
		  	$2,000,000 products/completed operations aggregate

 The General Contractor is required to maintain, during the construction period and up to 3 years after project
completion, a General Liability insurance policy, covering bodily injury, personal injury, property damage, completed operations, with limits to include a $1,000,000 limit for blanket contractual liability coverage and adding Landlord as additional
insured as respects the project during construction and for completed operations up to 3 years after the end of the project. Landlord requires a copy of the ISO 20 10 11 85 Additional Insured endorsement, showing Landlord as an additional insured to
the GC’s policy. 
  

			
	 (b)   Auto Liability
	  	 $1,000,000 combined single limit (Any Auto) 

		  	 for bodily injury and property damage,

		  	 hired and non-owned cover. 

  

			
	 (c)   Workers Compensation
Employers Liability
	  	 Statutory Limits
 $1,000,000 each
accident*

		  	 $1,000,000 each employee*

		  	$1,000,000 policy limit*
		
		  	 * or such amounts as are customarily
 obtained
by operators of comparable businesses

  
 EXHIBIT 10, PAGE 1 

 General Contractor shall ensure that any and all
sub-contractors shall maintain equal limits of coverage for Workers Compensation/EL and collect insurance certificates verifying same. 
  

			
	 (d)   Umbrella/Excess Liability
	  	 For projects, the cost of which is $1,000,000 or less: $5,000,000 per occurrence

		
		  	 For projects, the cost of which is more than $1,000,000: $10,000,000 per occurrence 

 (e) Environmental Insurance – To the extent required by Landlord Contractors’ commercial general
liability/umbrella insurance policy(ies) shall include Landlord and Landlord’s designees as additional insureds’, and shall include a primary non-contributory provision. Liability policy shall
contain a clause that the insurer may not cancel or materially change coverage without first giving Landlord thirty (30) days prior written notice, except cancellation for non-payment of premium, in which
ten (10) days prior written notice shall be required. 
 (3) Deductibles. If any of the above insurances have deductibles or
self-insured retentions, the Tenant and/or contractor (policy Named Insured) shall be responsible for the deductible amount. 
 All of the
insurance policies required in this Exhibit 10 shall be written by insurance companies which are licensed to do business in the State where the property is located, or obtained through a duly authorized surplus lines insurance agent or
otherwise in conformity with the laws of such state, with an A.M. Best rating of at least A and a financial size category of not less than VII. Tenant shall provide Landlord with certificates of insurance: (i) upon request from Landlord,
(ii) prior to commencement of the Tenant/contractor work, and (iii) upon coverage inception and subsequent renewals or rewrites/replacements of any cancelled/non-renewed policies. 

  
 EXHIBIT 10, PAGE 2 

 EXHIBIT 11 

ADDITIONAL PROVISIONS 
  

	I.	 TENANT’S EXPANSION OPTION. 

On the conditions (which conditions Landlord may waive, at its election, by written notice to Tenant at any time) that: (i) Kaleido
Biosciences, Inc. itself, and/or any Permitted Transferee(s) is/are then occupying at least sixty-five percent (65%) of the Premises; and (ii) no uncured Event of Default exists (1) as of the date of the Expansion Notice (hereinafter
defined), and (2) at the commencement of the and as of the Term Commencement Date of the Term of the Lease with respect to the Expansion Premises, as hereinafter defined, Tenant shall have the following right to lease the Expansion Premises, as
hereinafter defined. 
  

	 	A.	 Definition of Expansion Premises 

“Expansion Premises” shall be defined, at Tenant’s written election (which election Tenant shall make in
its Expansion Exercise Notice, as hereinafter defined), as either (x) the entire second (2nd) floor of the north portion of the Building, containing approximately 54,468 rentable square feet,
as shown on Exhibit 1C of the Lease, (y) the portion of said second floor of the Building, shown as “Expansion Premises A” on Exhibit 1C-A of the Lease,
containing approximately 32,103 rentable square feet, or (z) the portion of said second floor of the Building, shown as “Expansion Premises B” on Exhibit
1C-B of the Lease, containing approximately 22,365 rentable square feet. 
  

	 	B.	 Exercise of Right to Lease Expansion Premises 

Tenant may exercise its right to lease the Expansion Premises by giving Landlord written notice (“Expansion Exercise Notice”)
on or before the Last Expansion Notice Date, as hereinafter defined. Subject to the provisions of this Section IB, the “Last Expansion Exercise Notice Date” shall be
defined as April 1, 2019. Landlord shall, on or after October 1, 2018, but not later than March 1, 2019, give Tenant written notice (“Landlord’s Reminder Notice”), reminding Tenant of its
right to the lease the Expansion Premises pursuant to this Section IB and the last date on or before which Tenant has the right to give its Expansion Exercise Notice. If Landlord fails to give Landlord’s Reminder Notice on or before
March 1, 2019, then, and as Tenant’s sole right and remedy, the Last Notice Date shall be thirty (30) days after Landlord gives Landlord’s Reminder Notice to Tenant. If Tenant fails timely to give the Expansion Exercise Notice,
Tenant shall have no further right to lease such Expansion Premises pursuant to this Section I.  

  
 EXHIBIT 11, PAGE 1 

	 	C.	 Terms Applicable to Expansion Premises 

The leasing to Tenant of the Expansion Premises shall be upon all of the same terms and conditions of the Lease applicable to the South
Premises, except as set forth below: 
 (1) Term. The Term Commencement Date with respect to the Expansion Premises (the
“Expansion Premises Term”) shall be the latest of: (i) December 1, 2019, (ii) eight (8) months after Tenant gives a timely Expansion Exercise Notice to Landlord, and (iii) the date the
current tenant of the Expansion Premises vacates the Expansion Premises. The date which is the later of December 1, 2019, and eight (8) months after Tenant gives a timely Extension Exercise Notice to Landlord is referred to as the
“Expected Expansion Premises Term Commencement Date”. The Expiration Date with respect to the Expansion Premises shall be the day immediately preceding the tenth
(10th) anniversary of the Expansion Premises Base Rent Commencement Date, as hereinafter defined, except that if the Expansion Premises Base Rent Commencement Date does not occur on the first day
of a calendar month, then the Expiration Date with respect to the Expansion Premises shall be the last day of the calendar month in which the tenth (10th) anniversary of the Expansion Premises
Base Rent Commencement Date occurs. 
 (2) Base Rent Commencement Date. The Base Rent Commencement Date with respect of the Expansion
Premises (the “Expansion Premise Base Rent Commencement Date”) shall be the earlier of: (x) the date that is three (3) months after the Expansion Premises Term Commencement Date and (y) the date
Tenant commences to use the Expansion Premises, or any portion thereof, for the Permitted Use. 
 (3) Annual Base Rent. The Annual
Base Rent with respect to the Expansion Premises shall be based upon the same rate per rentable square foot as is payable by Tenant with respect to the North Premises, from time to time, as detailed in the attached Exhibit 12. The South
Premises Base Rent Abatement Period shall not apply to the Expansion Premises. 
 (4) Tenant’s Share of Operating Costs and
Taxes. The Additional Rent Commencement Date with respect to the Expansion Premises shall be the Base Rent Commencement Date with respect to the Expansion Premises. Tenant’s Share with respect to the Expansion Premises shall be a fraction,
the numerator of which is the rentable area of the Expansion Premises and the denominator of which is the rentable area of the Building, i.e. if the Expansion Premises are: 

The entire second floor of the north portion of the Building: 25.57% 

Expansion Premises A: 15.07% 

Expansion Premises B: 10.50% 

(5) Condition of Expansion Premises. Tenant shall take the Expansion Premises “as-is”
in its then (i.e., as of the date of premises delivery) state of construction, finish, and decoration, without any obligation on the part of Landlord to construct or prepare the Expansion Premises for Tenant’s occupancy. Without limiting the
foregoing, Sections 3.2 and 3.3 of the Lease shall not apply to the Expansion Premises. Notwithstanding the foregoing: (i) Landlord shall provide to Tenant a tenant improvement allowance (“Landlord’s Expansion Premises
Contribution”) of up to $70.00 per rentable square foot of the Expansion Premises (i.e., up to $3,812,760.00 if the Expansion Premises consists of the entire second (2nd)
floor of the north portion of the Building; up to $2,247,210.00 if the Expansion Premises consists of Expansion Premises A; or up to $1,565,550.00 if the Expansion Premises consists of Expansion 

  
 EXHIBIT 11, PAGE 2 

 
Premises B) to be used by Tenant to pay for Permitted Costs incurred by Tenant in preparing Landlord’s Expansion Premises for Tenant’s occupancy (“Expansion Premises
Permitted Costs”) and (ii) in the event Tenant elects to lease either Expansion Premises A or Expansion Premises B, as the case may be, Landlord shall, at Tenant’s
sole cost and expense, install demising wall(s) separating the applicable Expansion Premises from the remainder of the floor and separate the utilities, fire/life/safety systems, ceiling system, HVAC ducts and diffusers and other Building
mechanical, electrical and plumbing systems between the applicable Expansion Premises and the remainder of the floor so as to permit the use and occupancy of the applicable Expansion Premises and the remainder of the floor in accordance with all
applicable laws, rules and regulations. All such work (collectively, “Landlord’s Demising Work”) shall be performed in a good and workmanlike manner and in a manner similar to and consistent with the Building
standard improvements in the Building. The provisions of Exhibit 4 of the Lease (other than Section I) shall apply to the Expansion Premises, except: 
  

	 	•	 	 Design/Development Plans: Tenant shall deliver its Design/Development Plans for the Expansion Premises to
Landlord on or before the date that is five (5) months prior to the Expected Expansion Premises Term Commencement Date. 

  

	 	•	 	 Final Construction Drawings: Tenant shall deliver its Final Construction Drawings for the Expansion
Premises to Landlord on or before the date that is two (2) months prior to the Expected Expansion Premises Term Commencement Date. 

  

	 	•	 	 Outside Tenant Work Completion Date: The Outside Tenant Work Completion Date for the Expansion Premises
shall be fifteen (15) months after the Expansion Premises Base Rent Commencement Date. 

  

	 	•	 	 Maximum Amount of Landlord’s Expansion Premises Contribution: $70.00 per rentable square foot of the
Expansion Premises. 

  

	 	•	 	 Limitation on Soft Costs and Other Costs in Connection with Landlord’s Expansion Premises
Contribution: $7.00 per rentable square foot of the Expansion Premises. 

  

	 	•	 	 Outside Expansion Premises Requisition Date: June 30, 2021. 

 

	 	•	 	 Use of Landlord’s Expansion Premises Contribution to Pay for North Premises and South Premises
Improvements: Provided that each portion of the Premises is improved to the Minimum Improvement Standard, Tenant may, at Tenant’s written election, apply any unused portion of Landlord’s Expansion Premises Contribution towards the
North Premises Permitted Costs and the South Premises Permitted Costs. If Tenant makes such election, then the unused portion of Landlord’s Expansion Premises Contribution so designated by Tenant shall become part of Landlord’s North
Premises Contribution and/or Landlord’s South Premises Contribution, as the case may be. 

  
 EXHIBIT 11, PAGE 3 

	 	•	 	 Tenant’s Right to Apply Landlord’s North Premises Contribution and South Premises Contribution to
Expansion Premises Permitted Costs. Provided that each portion of the Premises is improved to the Minimum Improvement Standard, Tenant may, at Tenant’s written election, apply any unused portion of Landlord’s North Premises
Contribution and any unused portion of Landlord’s South Premises Contribution towards the Expansion Premises Permitted Costs. Notwithstanding anything to the contrary herein contained, Tenant may not use any portion of Landlord’s North
Premises Contribution or Landlord’s South Premises Contribution to pay for Tenant’s Work in the Expansion Premises until after the initial improvements in both the North Premises and South Premises have both been completed to the Minimum
Improvement Standard. Landlord expressly agrees that: (i) since Tenant is committed to the performance of Landlord’s South Premises Work listed on Exhibits 4-3 and 4-4 attached hereto, and (ii) for the avoidance of doubt, Tenant has the right to apply any unused portion of the Landlord’s South Premises Contribution towards the North Premises Permitted Cost and
(if Tenant timely and properly exercises its right to lease the Expansion Premises) to the Expansion Premises Permitted Costs. If Tenant makes such election, then the unused portion of Landlord’s North Premises Contribution and/or
Landlord’s South Premises Contribution so designated by Tenant shall become part of Landlord’s Expansion Premises Contribution. 

(6) Parking. Landlord shall make available up to 2.5 additional Parking Spaces each per 1,000 rentable square feet of the Expansion
Premises to Tenant in connection with Tenant’s demise of the Expansion Premises. 
 (7) Extension Option for Expansion Premises.
In the event Tenant timely exercises its Extension Option for the Prime Premises in accordance with the terms and conditions set forth in Section 1.2 of this Lease, Tenant shall have the option (“Stub Extension
Option”) to extend the Term of the Lease with respect to the Expansion Premises for the period commencing on the day immediately following the expiration of the Expansion Term and expiring on the last day of the Extension Term
for the Prime Premises, as set forth in Section 1.2 of this Lease (“Stub Extension Period”). Tenant’s right to exercise the Stub Extension Option shall be upon all of the same terms and conditions set forth
in Section 1.2 of the Lease, except that: 
 (i) Tenant must give its Extension Notice with respect to the Stub
Extension Period at the same time that Tenant gives Landlord its Extension Notice for the Extension Term with respect to the Prime Premises. 

(ii) The Base Rent payable for the Expansion Premises during the Stub Extension Period shall be at the same rate per rentable
square foot as is then payable by Tenant with respect to the Prime Premises: 

  
 EXHIBIT 11, PAGE 4 

 (iii) Tenant shall have no further right to extend the Term of the Lease
with respect to the Expansion Premises beyond the Stub Extension Period. 
 If Tenant fails to give timely notice exercising
the Stub Extension Option, Tenant shall have no further right to extend the Term with respect to the Expansion Premises. 
 D. Execution
of Lease Amendments. Notwithstanding the fact that Tenant’s exercise of the above-described option to lease the Expansion Premises shall be self-executing, as aforesaid, the parties hereby agree promptly to execute a lease amendment
reflecting the addition of the Expansion Premises. The execution of such lease amendment shall not be deemed to waive any of the conditions to Tenant’s exercise of the herein option to lease the Expansion Premises, unless otherwise specifically
provided in such lease amendment. 
 II. TENANT’S RIGHT TO NEGOTIATE TO LEASE OF ADDITIONAL PREMISES IN THE EVENT LANDLORD CONSTRUCTS ANOTHER
BUILDING ON THE CAMPUS 
 A. Background. Reference is made to the fact that Landlord intends to construct a four-story building on
the Campus: (i) to be known as and located at 75 Hayden Avenue, Lexington, MA (“75 Hayden”), and (ii) the second, third and fourth floors of 75 Hayden will each contain at least 50,000 rentable square feet.
Tenant expressly acknowledges and agrees that Landlord has no obligation to construct 75 Hayden and that this Section II shall be void and without force or effect if Landlord, in its sole discretion, elects not to construct 75 Hayden. Landlord
estimates that: (i) the construction of 75 Hayden on site (the “Groundbreaking”) will occur on or about August 1, 2018, and (ii) the substantial completion of the shell of 75 Hayden will occur on or about
February 1, 2020. 
 B. RTN Premises. The “RTN Premises” shall be defined as either the second,
third or fourth floor of 75 Hayden, at Landlord’s sole election. 
 C. Tenant’s Right to Negotiate. On the conditions
(which conditions Landlord may waive, at its election, by written notice to Tenant at any time) that: (i) Landlord commences construction of 75 Hayden, (ii) Kaleido Biosciences, Inc. itself, and/or any Permitted Transferee(s) is/are then
occupying at least sixty-five percent (65%) of the Premises; (iii) no uncured Event of Default exists (1) as of the date that Landlord gives Landlord’s Offer, as hereinafter defined, to Tenant, (iv) Kaleido Biosciences, Inc. has
reached a valuation of Five Hundred Million Dollars ($500,000,000) calculated on a fully-diluted basis (assuming exercise of all options, regardless of whether outstanding, warrants and other convertible securities) based on the last price paid for
shares of Preferred Stock of Kaleido Biosciences, Inc., as of the time of Landlord’s Offer, (v) Tenant timely and properly exercises its right to lease the Expansion Premises pursuant to Section I of this Exhibit 11, and (vi) this
Lease is then in full force and effect, then Tenant shall have the following one-time right to lease the RTN Premises, as hereinafter defined, on terms and conditions to be determined by Landlord as specified
in Landlord’s Offer, as hereinafter defined. Landlord shall, not earlier than the date that is twelve (12) months after the Groundbreaking and not later than the date that is seventeen (17) months after the Groundbreaking (the
“Offer Period”) give Tenant written notice (“Landlord’s Offer”) 

  
 EXHIBIT 11, PAGE 5 

 
specifying the terms on which Landlord, in its sole judgment, is willing to lease the RTN Premises to Tenant. Tenant may accept Landlord’s Offer by giving a written acceptance
(“Tenant’s Acceptance”) to Landlord on or before the date (“Last Acceptance Date”) which is the earlier of: (x) eighteen (18) months after the Groundbreaking or (ii) six
(6) months after Landlord’s Offer. Notwithstanding the foregoing, if Landlord fails to give Landlord’s Offer to Tenant within the Offer Period, then the Last Notice Date shall be the date thirty (30) days after Landlord gives
Landlord’s Offer to Tenant. If Tenant fails timely to give Tenant’s Acceptance, then Tenant shall have no further right to lease the RTN Premises. If Tenant timely gives Tenant’s Acceptance to Landlord, then the parties shall
negotiate to enter into a mutually acceptable lease on the terms set forth in Landlord’s Offer. However, if, for any reason, the parties do not, for any reason, enter into a mutually acceptable lease on the terms set forth in Landlord’s
Offer, then Tenant shall have no further right to lease the RTN Premises. 
 D. Tenant’s Right to Negotiate is Subject to Lease of
Entirety of 75 Hayden. Notwithstanding anything to the contrary herein contained, if, on or before the Last Acceptance Date, Landlord accepts an offer from a third party to lease the entirety of 75 Hayden then, even if Tenant has already
accepted Landlord’s Offer and entered into a lease of the RTN Premises, Tenant’s Acceptance and such lease shall be void and without force or effect, and Tenant shall have no further right to lease the RTN Premises. 

III. TENANT’S FINANCING CONTINGENCY. 

If Tenant does not, on or before March 19, 2018, provide to Landlord evidence, reasonably satisfactory to Landlord that Tenant has
successful raised at least an additional $60 million in capital (“Tenant Financing Contingency”), then both Landlord and Tenant shall have the right to cancel this Lease. In such event: (i) the provisions of
a certain letter agreement between the parties dated March 2, 2018 shall apply, (ii) this Lease shall be void and without further force or effect, and (iii) neither party shall, except as set forth in this Section III, have any
further obligation to the other party. 
 IV. TENANT’S EMERGENCY GENERATOR 

In addition to, Tenant’s right to connect its equipment to the Existing Generator, as set forth in Section 1.8 of the Lease, Tenant
shall have the right, at Tenant’s election to demise the Generator Area, as hereinafter defined, if Tenant, in its sole discretion, determines that either: (i) the Generator Servicer is failing to maintain the Existing Generator in
operable condition, or (ii) the Existing Generator is insufficient to provide enough power to the Premises to service Tenant’s needs. In either such event, Landlord shall demise and lease the Generator Area, as hereinafter defined, to
Tenant, and Tenant shall hire and take the Generator Area from Landlord. The “Generator Area” shall be defined as an area outside of the Building, which shall be mutually agreed upon by Landlord and Tenant. Tenant
shall have the right to use the Generator Area solely for the purpose of installing a concrete pad and for the installation and use of Tenant’s own emergency generator (“Tenant’s Generator”) in accordance
with the provisions of this Section IV. The term of the Lease with respect to the Generator Area shall commence as of the date that Tenant first commences work installing said concrete pad (“Commencement Date in respect of
Tenant’s Generator”) and shall terminate as of the Expiration Date of the Lease, as such date may be extended pursuant to Section 1.2 of this Lease (Tenant’s Generator 

  
 EXHIBIT 11, PAGE 6 

 
and the Generator Area are deemed to be the “Generator Premises”). Said demise of Tenant’s Generator Area shall be upon all of the same terms and conditions of the
Lease, except as set forth herein. Tenant shall not install or operate Tenant’s Generator until Tenant has obtained and submitted to Landlord copies of all required governmental permits, licenses, and authorizations necessary for the
installation and operation of Tenant’s Generator. In addition, Tenant shall comply with all reasonable construction rules and regulations promulgated by Landlord in the maintenance and operation of Tenant’s Generator. Tenant shall be
permitted to use Tenant’s Generator Area solely for the maintenance and operation of Tenant’s Generator, and Tenant’s Generator and Generator Area are solely for the benefit of Tenant and/or any Permitted Transferee. All electricity
generated by Tenant’s Generator may only be consumed by Tenant in the Premises. 
 (i) Tenant shall, at Tenant’s cost, landscape
or screen, as directed by Landlord, the area around Tenant’s Generator Area. 
 (ii) Tenant shall have no obligation to pay Base Rent,
costs and expenses of the Common Areas, or Taxes in respect of Tenant’s Generator Area. 
 (iii) Landlord shall have no obligation to
provide any services including, without limitation, electric current, to Tenant’s Generator Area; provided, however, that Tenant, at Tenant’s sole cost, shall, subject to the provisions of this Lease (including, without limitation,
Section 11 hereof) shall have the right to install wiring in locations designated by Landlord in order to connect Tenant’s Generator to Tenant’s electrical system serving the Prime Premises. 

(iv) Tenant shall have no right to make any changes, alterations, additions, decorations or other improvements (collectively
“Installations”) to Tenant’s Generator Area without Landlord’s prior written consent, which consent Landlord may withhold in its sole but bona fide business judgment. 

(v) Tenant may remove Tenant’s Generator and any Installations at any time during the Term of the Lease upon prior written notice to
Landlord, provided that Tenant restores Tenant’s Generator Area to the same condition as the area surrounding Tenant’s Generator at the time of such removal. 

(vi) Tenant shall be responsible for the cost of repairing any damage to the Building caused by the installation of Tenant’s Generator
and/or any Installations. 
 (vii) Tenant shall have no right to sublet Tenant’s Generator Area or to assign its interest hereunder,
other than to a Permitted Transferee, as defined in Section 13.7 of this Lease. 
 (viii) To the maximum extent permitted by law,
Tenant’s Generator and all Installations in Tenant’s Generator Area shall be at the sole risk of Tenant, and Landlord shall have no liability to Tenant in the event that Tenant’s Generator or any Installations are damaged for any
reason, except to the extent caused by the negligent acts, negligent omissions or willful misconduct of Landlord or any Landlord Parties. 

  
 EXHIBIT 11, PAGE 7 

 (ix) Tenant shall take Tenant’s Generator Area
“as-is” in the condition in which Tenant’s Generator Area is in as of the Commencement Date in respect of Tenant’s Generator, without any obligation on the part of Landlord to prepare or
construct Tenant’s Generator Area for Tenant’s use or occupancy. Without limiting the foregoing, Landlord makes no warranties or representations to Tenant as to the suitability of Tenant’s Generator Area for the installation and
operation of Tenant’s Generator. Notwithstanding the foregoing, at Tenant’s written election, Tenant may include the installation of Tenant’s Generator on Tenant’s Generator Area as part of Landlord’s Work, in which event,
the costs incurred by Landlord in installing so installing Tenant’s Generator shall be included as part of the Cost of Landlord’s Work.  

(x) In addition to and without limiting Tenant’s obligations under the Lease, Tenant shall comply with all applicable environmental and
fire prevention laws, ordinances and regulations in Tenant’s use of Tenant’s Generator Area. 
 (xi) In addition to and without
limiting Tenant’s obligations under the Lease, Tenant covenants and agrees that Tenant’s use of Tenant’s Generator and Installations shall not adversely affect the insurance coverage for the Building. If for any reason, the
installation or use of Tenant’s Generator and/or the Installations shall result in an increase in the amount of the premiums for such coverage, then Tenant shall be liable for the full amount of any such increase. 

(xii) Tenant shall, at Tenant’s sole cost and expense, repair and maintain Tenant’s Generator and Installations. 

(xiii) In addition to and without limiting the insurance provisions of the Lease, Tenant shall procure, keep in force and pay for Commercial
General Liability Insurance in respect of Tenant’s Generator Area of not less than One Million ($1,000,000.00) Dollars in the event of personal injury to any number of persons or damage to property, arising out of any one occurrence and such
insurance shall name Landlord as an additional insured party. Tenant shall have the right to maintain the aforesaid insurance under umbrella coverages. 

(xiv) In addition to and without limiting the indemnification provisions set forth in the Lease, Tenant shall, to the maximum extent permitted
by law and subject to Section 14.5, indemnify, defend, and hold Landlord harmless from any and all claims, losses, demands, actions, or causes of actions suffered by any person, firm, corporation, or other entity arising from Tenant’s use
of Tenant’s Generator Area, except to the extent caused by the negligent acts, negligent omissions or willful misconduct of Landlord or any Landlord Parties.  

  
 EXHIBIT 11, PAGE 8 

 EXHIBIT 12 

ANNUAL BASE RENT PER RSF AMOUNTS 
  

			
	Rent Year	  	Annual Base Rent Per RSF
	 1
	  	$52.50
	 2
	  	$54.08
	 3
	  	$55.70
	 4
	  	$57.37
	 5
	  	$59.09
	 6
	  	$60.86
	 7
	  	$62.69
	 8
	  	$64.57
	 9
	  	$66.51
	 10
	  	$68.50
	 11
	  	$70.56

  
 EXHIBIT 12, PAGE 1 

 EXHIBIT 13 

TENANT’S MONUMENT SIGNAGE 
 

 

  
 EXHIBIT 13, PAGE 1

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