Document:

exv4w3

Exhibit 4.3

EXECUTION VERSION

SUPPLEMENTAL INDENTURE

RELATED TO THE COMPLETION DATE

     SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”) dated as of June 1, 2011, among
GRIFOLS INC., a Virginia corporation (the “Company”), GRIFOLS, S.A., a company organized
under the laws of the Kingdom of Spain (“Parent”), the subsidiaries of Parent set forth on
the signature pages hereto (the “Subsidiary Guarantors” and together with Parent, the
“Guarantors”) and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as trustee under the
indenture referred to below (the “Trustee”).

W I T N E S S E T H:

     WHEREAS, Giant Funding Corp. (the “Escrow Issuer”) has heretofore executed and
delivered to the Trustee an indenture (as amended, supplemented or otherwise modified, the
“Indenture”) dated as of January 21, 2011, providing for the issuance of Escrow Issuer’s
$1,100,000,000 aggregate principal amount of the 8.25% Senior Notes due 2018 (the “Notes”);

     WHEREAS, pursuant to Section 9.01 of the Indenture, the Trustee, the Company and the
Guarantors are authorized to execute and deliver this Supplemental Indenture;

     WHEREAS, all other acts and proceedings required by law and the Indenture necessary to
authorize the operation and delivery of this Supplemental Indenture and to make this Supplemental
Indenture a valid and binding agreement for the purposes of expressed herein, in accordance with
its terms have been complied with or have been duly done or performed;

     NOW THEREFORE, in consideration of the foregoing and for other good and valuable
consideration, the receipt of which is hereby acknowledged, the Company, the Guarantors and the
Trustee mutually covenant and agree for the equal and ratable benefit of the holders of the Notes
as follows:

     1. Defined Terms. As used in this Supplemental
Indenture, terms defined in the Indenture or in the preamble or recital hereto
are used herein as therein defined, except that the term “Holders” in this
Supplemental Indenture shall refer to the term “Holders” as defined in the
Indenture and the Trustee acting on behalf of and for the benefit of such
Holders. The words “herein,” “hereof” and “hereby” and other words of similar
import used in this Supplemental Indenture refer to this Supplemental
Indenture as a whole and not to any particular section hereof.

     2. Agreement to Assume Obligations. The Company hereby agrees to
unconditionally assume the Escrow Issuer’s Obligations under the Notes and the Indenture on
the terms and subject to the conditions set forth in the Indenture and to be bound by all
applicable provisions of the Indenture and the Notes and to perform all of the obligations
and agreements of the Escrow Issuer under the Indenture.

     3. Agreement to Guarantee. The Guarantors hereby agree, jointly and severally,
to unconditionally guarantee the Company’s Obligations under the Notes and the Indenture on
the terms and subject to the conditions set forth in Article 10 of the Indenture and to be
bound by all other applicable provisions of the Indenture and the Notes and to perform all
of the obligations and agreements of a guarantor under the Indenture.

 

 

     4. Notices. All notices or other communications to the Company and the
Guarantors shall be given as provided in Section 12.02 of the Indenture.

     5. Ratification of Indenture; Supplemental Indentures Part of Indenture. Except as
expressly amended hereby, the Indenture is in all respects ratified and confirmed and all the
terms, conditions and provisions thereof shall remain in full force and effect. This Supplemental
Indenture shall form a part of the Indenture for all purposes, and every Holder of Notes
heretofore or hereafter authenticated and delivered shall be bound hereby.

     6. Limitation on Guarantor Liability. To the extent a Guarantor which is a German
limited liability company (Gesellschaft mit beschränkter Haftung — GmbH) or a limited partnership
(Kommanditgesellschaft) with a GmbH as its sole general partner (Komplementär) (GmbH & Co. KG)
(the “Affected German Guarantor”) guarantees Obligations under the Agreement, the parties hereto
agree that enforcement of that guaranty shall be limited to the extent that such payment under
this guaranty has the effect of (i) reducing the Affected German Guarantor’s Net Assets
(Nettovermögen) to an amount less than its share capital (Stammkapital)(Begründung einer
Unterbilanz), and , as a result, cause a violation of Section 30 of the German Limited Liability
Companies Act (GmbH-Gesetz) or (ii) if its Net Assets are already an amount less than its share
capital (Stammkapital), causing such Net Assets to be further reduced (Vertiefung einer
Unterbilanz), and, as a result, cause a violation of Section 30 of the German Limited Liability
Companies Act (GmbH-Gesetz) or (iii) violating other applicable German law which may cause the
managing directors of the Affected German Guarantor to be personally liable.

     For purposes of this Section, “Net Assets” shall mean the assets, pursuant to Section 266 (2)
(A), (B), (C), (D) and (E) of the German Commercial Code (Handelsgesetzbuch) less the sum of the
non-subordinated liabilities pursuant to Section 266 (3) (B), (C), (D) and (E) of the German
Commercial Code (Handelsgesetzbuch). The value of the Net Assets shall be determined in accordance
with general accepted accounting principles (Grundsätze ordnungsgemäßer Buchführung) under the
German Commercial Code (HGB) consistently applied by the Affected German Guarantor in preparing
its unconsolidated balance sheets (Jahresabschluss) according to Section 42 German Limited
Liability Companies Act (GmbHG), Sections 242, 264 German Commercial Code (HGB) in the previous
years.

     6. Release of Obligations of Giant Funding Corp. Upon execution of this
Supplemental Indenture by the Company and the Trustee, the Escrow Issuer is released
and discharged from all obligations under the Indenture and the Notes.

     7. Governing Law. THIS SUPPLEMENTAL INDENTURE SHALL BE
GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK.

     8. Trustee Makes No Representation. The Trustee makes no representation as to the
validity or sufficiency of this Supplemental Indenture or for or in respect of the recitals
contained herein, all of which recitals are made solely by the Company.

     9. Counterparts. The parties may sign any number of copies of this
Supplemental Indenture. Each signed copy shall be an original, but all of them
together represent the same agreement.

 

 

     10. Effect of Headings. The Section headings herein are for convenience only and
shall not effect the construction thereof.

 

 

     IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed as of the date first above written.

	 	 	 	 	 
	 	GRIFOLS INC.

 	 
	 	By:  	/s/ David Bell
 	 
	 	 	Name:  	David Bell 	 
	 	 	Title:  	Vice President 	 
	 
	 	GRIFOLS, S.A.

 	 
	 	By:  	/s/ Victor Grifols
 	 
	 	 	Name:  	Victor Grifols 	 
	 	 	Title:  	Chairman and CEO 	 
	 
	 	INSTITUTO GRIFOLS, S.A.

 	 
	 	By:  	/s/ Victor Grifols
 	 
	 	 	Name:  	Victor Grifols 	 
	 	 	Title:  	President and CEO 	 
	 
	 	GRIFOLS BIOLOGICALS INC..

 	 
	 	By:  	/s/ David Bell
 	 
	 	 	Name:  	David Bell 	 
	 	 	Title:  	Vice President 	 
	 
	 	BIOMAT USA INC.

 	 
	 	By:  	/s/ David Bell
 	 
	 	 	Name:  	David Bell 	 
	 	 	Title:  	Chairman 	 
	 
	 	MOVACO, S.A.

 	 
	 	By:  	/s/ Victor Grifols
 	 
	 	 	Name:  	Victor Grifols 	 
	 	 	Title:  	Joint and Several Director 	 

 

 

	 	 	 	 	 

	 	 	 	 	 
	 	GRIFOLS ITALIA, S.P.A.

 	 
	 	By:  	/s/ Victor Grifols
 	 
	 	 	Name:  	Victor Grifols 	 
	 	 	Title:  	Attorney-in-Fact 	 
	 
	 	LABORATORIOS GRIFOLS, S.A.

 	 
	 	By:  	/s/ Victor Grifols
 	 
	 	 	Name:  	Victor Grifols 	 
	 	 	Title:  	Joint and Several Director 	 
	 
	 	GRIFOLS DEUTSCHELAND GMBH

 	 
	 	By:  	/s/ Ramon Riera
 	 
	 	 	Name:  	Ramon Riera 	 
	 	 	Title:  	Managing Director 	 
	 
	 	By:  	/s/ Diego Nuñez
 	 
	 	 	Name:  	Diego Nuñez 	 
	 	 	Title:  	Managing Director 	 
	 
	 	DIAGNOSTIC GRIFOLS, S.A.

 	 
	 	By:  	/s/ Victor Grifols
 	 
	 	 	Name:  	Victor Grifols 	 
	 	 	Title:  	Joint and Several Director 	 
	 
	 	TALECRIS BIOTHERAPEUTICS INC.

 	 
	 	By:  	/s/ David Bell
 	 
	 	 	Name:  	David Bell 	 
	 	 	Title:  	Vice President 	 
	 
	 	TALECRIS PLASMA RESOURCES INC.

 	 
	 	By:  	/s/ David Bell
 	 
	 	 	Name:  	David Bell 	 
	 	 	Title:  	Vice President 	 

 

 

	 	 	 	 	 

	 	 	 	 	 
	 	THE BANK OF NEW YORK MELLON TRUST

COMPANY, N.A., as Trustee

 	 
	 	By:  	/s/
Christie Leppert
 	 
	 	 	Name:  	Christie Leppert 	 
	 	 	Title:  	Vice Presidentexv4w4

Exhibit 4.4

SECOND SUPPLEMENTAL INDENTURE

     This SECOND SUPPLEMENTAL INDENTURE (the “Second Supplemental
Indenture”) dated as of October 4, 2011, among GRIFOLS DEUTSCHLAND GMBH, a German corporation (the
“Guaranteeing Subsidiary”), GRIFOLS INC., a Virginia corporation (the “Company”), and THE BANK OF
NEW YORK MELLON, N.A., as trustee under the Indenture referred to below (the “Trustee”).

W I T N E S S E T H:

     WHEREAS, the Company has heretofore executed and delivered to the Trustee a
supplemental indenture, dated June 1, 2011 pursuant to which the Company agreed to
unconditionally assume the Escrow Issuer’s Obligations under the indenture, dated as of
January 21, 2011 (the “Indenture”), providing for the initial issuance of $1,100,000,000
aggregate principal amount of 8.25% Senior Notes due 2018 (the “Notes”) and the Notes on
the terms and subject to the conditions set forth in the Indenture;

     WHEREAS, the Indenture provides that under certain circumstances subsequent
subsidiary guarantors shall execute and deliver to the Trustee a supplemental indenture
pursuant to which the Guaranteeing Subsidiary shall unconditionally guarantee all of the
Company’s Obligations under the Notes and the Indenture on the terms and conditions set
forth herein and under the Indenture (the “Guarantee”); and

     WHEREAS, pursuant to Section 9.01 of the Indenture, the Trustee is authorized to
execute and deliver this Second Supplemental Indenture.

     NOW THEREFORE, in consideration of the foregoing and for other good and valuable
consideration, the receipt of which is hereby acknowledged, the parties mutually covenant
and agree for the equal and ratable benefit of the Holders of the Notes as follows:

     (1) Capitalized Terms. Capitalized terms used herein without definition shall have
the meanings assigned to them in the Indenture.

     (2) Agreement to Guarantee. The Guaranteeing Subsidiary hereby agrees as follows:

     (a) The Guaranteeing Subsidiary hereby becomes a party to the Indenture as a
Guarantor and as such will have all of the rights and be subject to all of the
obligations and agreements of a Guarantor under the Indenture. The Guaranteeing
Subsidiary agrees to be bound by all of the provisions of the Indenture applicable
to a Guarantor and to perform all of the obligations and agreements of a Guarantor
under the Indenture.

     (b) The Guaranteeing Subsidiary agrees, on a joint and several basis with all
the existing Guarantors, to fully, unconditionally and irrevocably Guarantee to
each Holder of the Notes and the Trustee the Obligations pursuant to Article 10 of
the Indenture on a senior basis.

     (3) Limitation on Guarantor Liability. To the extent a Guarantor or Guaranteeing
Subsidiary which is a German limited liability company (Gesellschaft mit beschränkter
Haftung – GmbH) or a limited partnership (Kommanditgesellschaft) with a GmbH as its sole
general partner

 

 

(Komplementär) (GmbH & Co. KG) (the “Affected German Guarantor”) guarantees Obligations under the
Indenture, the parties hereto agree that enforcement of that guaranty shall be limited to the
extent that a payment under this guaranty has the effect of (i) reducing the Affected German
Guarantor’s Net Assets (Nettovermögen) to an amount less than its share capital (Stammkapital)
(Begründung einer Unterbilanz), and, as a result, cause a violation of Section 30 of the German
Limited Liability Companies Act (GmbH-Gesetz) or (ii) of further reducing its Net Assets which are
already an amount less than its share capital (Stammkapital) (Vertiefung einer Unterbilanz), and,
as a result, cause a violation of Section 30 of the German Limited Liability Companies Act
(GmbH-Gesetz) or (iii) violating other applicable German law which may cause the managing
directors of the Affected German Guarantor to be personally liable.

     For purposes of this Section (3), “Net Assets” shall mean the assets, pursuant to
Section 266 (2) (A), (B), (C), (D) and (E) of the German Commercial Code
(Handelsgesetzbuch, HGB) less the sum of the non-subordinated liabilities pursuant to
Section 266 (3) (B), (C), (D) and (E) HGB. The value of the Net Assets shall be determined
in accordance with general accepted accounting principles (Grundsätze ordnungsgemäßer
Buchführung) under the HGB consistently applied by the Affected German Guarantor in
preparing its unconsolidated balance sheets (Jahresabschluss) according to Section 42
German Limited Liability Companies Act (GmbHG), Sections 242, 264 HGB in the previous
years.

     (4) Execution and Delivery. The Guaranteeing Subsidiary agrees that the Guarantee
shall remain in full force and effect notwithstanding the absence of the endorsement of any
notation of such Guarantee on the Notes.

     (5) Governing Law. THIS SECOND SUPPLEMENTAL INDENTURE SHALL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK

     (6) Counterparts. The parties may sign any number of copies of this Second
Supplemental Indenture. Each signed copy shall be an original, but all of them together
represent the same agreement.

     (7) Effect of Headings. The Section headings herein are for convenience only and
shall not affect the construction hereof.

     (8) The Trustee. The Trustee shall not be responsible in any manner whatsoever for or
in respect of the validity or sufficiency of this Second Supplemental Indenture or for or
in respect of the recitals contained herein, all of which recitals are made solely by the
Guaranteeing Subsidiary.

 

 

     IN WITNESS WHEREOF, the parties hereto have caused this Second Supplemental Indenture
to be duly executed, all as of the date first above written.

	 	 	 	 	 
	 	GRIFOLS DEUTSCHLAND GMBH

 	 
	 	By:  	/s/ Ramon Riera Roca
 	 
	 	 	Name:  	Ramon Riera Roca 	 
	 	 	Title:  	Managing Director 	 
	 
	 	 	 
	 	By:  	/s/ Alfredo Arroyo Guerra
 	 
	 	 	Name:  	Alfredo Arroyo Guerra 	 
	 	 	Title:  	Managing Director 	 
	 
	 	THE BANK OF NEW YORK MELLON, N.A., as Trustee

 	 
	 	By:  	/s/ Christie Leppert	 
	 	 	Name:  	Christie Leppert	 
	 	 	Title:  	Vice President	 
	 

Acknowledged by:

GRIFOLS INC.

	 	 	 	 	 
	 	 	 
	By:  	/s/
Greg Rich	 
	Name:  	Greg Rich
	Title:  	Chief Executive Officer
	 

[Grifols Inc. Second Supplemental Indenture Signature Page]

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