Document:

Warrant

 EXHIBIT 4.2 
  
 Xenogen - PFG Warrant 
  
 WARRANT 
  
 THIS WARRANT (THE “WARRANT”) IS ISSUED PURSUANT TO THE TERMS OF THE PROVISIONS OF A WARRANT PURCHASE AGREEMENT (THE “AGREEMENT”) BETWEEN XENOGEN CORPORATION (THE “COMPANY”) AND THE
INITIAL WARRANT HOLDER. A COPY OF SUCH AGREEMENT IS ON FILE AT THE OFFICE OF THE CORPORATE SECRETARY OF THE COMPANY. THIS SECURITY WAS SOLD IN A PRIVATE PLACEMENT, WITHOUT REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“SECURITIES ACT”), AND MAY BE OFFERED OR SOLD ONLY IF REGISTERED UNDER THE SECURITIES ACT OR IF AN EXEMPTION FROM REGISTRATION IS AVAILABLE. 
  

			
	Company:	 	Xenogen Corporation, a Delaware corporation (XGEN:
	 	 	NASDAQ)
	Number of Shares:	 	180,000, subject to Section 1.5
	Class of Shares:	 	Common, par value $0.001 per share
	Exercise Price:	 	$3.60
	Issue Date:	 	August 2, 2005
	Expiration Date:	 	August 1, 2012, subject to Section 1.5

  
 The term
“Holder” shall initially refer to Partners for Growth, L.P., a Delaware limited partnership, which is the initial holder of this Warrant and shall further refer to any subsequent permitted holder of this Warrant from time to time.

  
 The Holder is subject to certain restrictions as set forth in
the Agreement. 
  
 The Company does hereby certify and agree that
the Holder, or its permitted successors and assigns, hereby is entitled to purchase from Xenogen Corporation (the “Company”) One Hundred Eighty Thousand (180,000) duly authorized, validly issued, fully paid and non-assessable shares of its
Common Stock, par value $0.001 each, upon the terms and subject to the provisions of this Warrant. The number of shares subject to issuance under this Warrant may be reduced from time to time in accordance with Section 1.5 hereof. The shares of
Common Stock issuable upon exercise of this Warrant are referred to herein as the “Warrant Stock,” and the Warrant and the Warrant Stock are sometimes together referred to as the “Securities.” 
  
 Section 1. Term, Price and Exercise of Warrant. 
  
 1.1 Term of Warrant. This Warrant shall be exercisable for a period
of seven (7) years after the date hereof (hereinafter referred to as the “Expiration Date”). 

 1.2 Exercise Price. The price per share at which the Warrant Stock is issuable upon exercise of
this Warrant shall be $3.60, subject to adjustment from time to time as set forth herein (the “Exercise Price”). 
  
 1.3 Exercise of Warrant. 
  
 (a) This Warrant may be exercised or converted, in whole or in part, upon surrender to the Company at its then principal offices in the United States of
this Warrant to be exercised, together with the form of election to exercise attached hereto as Exhibit A duly completed and executed, and upon payment to the Company of the Exercise Price for the number of shares of Warrant Stock in respect of
which this Warrant is then being exercised. 
  
 (b) Payment of the
aggregate Exercise Price may be made (i) in cash or by cashier’s or bank check or (ii) by converting this Warrant through a Cashless Exercise (as defined herein). Upon a “Cashless Exercise” the Holder shall receive Warrant Stock on a
net basis such that, without the payment of any funds, the Holder shall surrender this Warrant in exchange for the number of shares of Warrant Stock equal to “X” (as defined below), computed using the following formula: 
  

			
	 X =
	 	    Y * (A-B)    
	 	        A

  
 Where 
  

					
	X	  	=	 	the number of shares of Warrant Stock to be issued to Holder.
	Y	  	=	 	the number of shares of Warrant Stock to be exercised under this Warrant
	A	  	=	 	the Fair Market Value of one share of Common Stock.
	B	  	=	 	the Exercise Price (as adjusted to the date of such calculations)
	*	  	=	 	multiplied by.

  
 (c) For purposes of
this Warrant, the “Fair Market Value” of one share of Warrant Stock shall be (i) if the Company’s common stock (the “Common Stock”) is on a national stock exchange or the Nasdaq National Market on a date of determination,
the average closing sale price reported on such exchange or market for the 5 consecutive trading days ending on the trading day immediately prior to the day the Company receives Holder’s Election of Exercise, or (ii) if the Common Stock is
traded over-the-counter, the average closing bid price for the Common Stock for the 5 trading days ending on the trading day immediately prior to the day the Company receives Holder’s Election of Exercise. If the Common Stock is not traded as
contemplated in clauses (i) or (ii), above, the Fair Market Value of the Company’s Warrant Stock shall be the price per share which the Company could obtain from a willing buyer for shares of Warrant Stock sold by the Company from its
authorized but unissued shares, as the Board of Directors of the Company shall determine in its reasonable good faith judgment. In the event that Holder elects to convert the Warrant Stock through Cashless Exercise in connection with 
  

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 a transaction in which the Warrant Stock is converted into or exchanged for another security, Holder may effect a
Cashless Exercise directly into such other security. Notwithstanding the right of the Holder to effect a Cashless Exercise, the Company may require Holder to exercise this Warrant for cash if the resale of the Warrant Stock is registered, such
Warrant Stock may be sold by Holder without restriction under SEC rules and regulations and applicable law (other than prospectus delivery and similar requirements) and such Warrant Stock is delivered within two trading days of Holder’s
exercise. 
  
 (d) Subject to Section 2 hereof including
Holder’s certification of its compliance with applicable securities laws, upon surrender of this Warrant, and the duly completed and executed form of election to exercise, and payment of the Exercise Price or conversion of this Warrant through
Cashless Exercise, the Company shall issue and deliver within three (3) trading days of such surrender and payment to the Holder or such other person as the Holder may designate in writing a certificate or certificates for the number of shares of
Warrant Stock so purchased upon the exercise or conversion of this Warrant. Such certificate or certificates shall be deemed to have been issued and any person so designated to be named therein shall be deemed to have become a holder of record of
such Warrant Stock as of the date of the surrender of this Warrant, and the duly completed and executed form of election to exercise, and payment of the Exercise Price or conversion of this Warrant through Cashless Exercise. If this Warrant is
exercised or converted in part, a new warrant of the same tenor and for the number of shares of Warrant Stock not exercised or converted shall be executed by the Company. 
  
 1.4 Fractional Interests. The Company shall not be required to issue fractions of shares of Warrant Stock upon the
exercise of this Warrant. If any fraction of a share of Common Stock would be issuable upon the exercise of this Warrant (or any portion thereof), the Company shall purchase such fraction for an amount in cash equal to the same fraction of the Fair
Market Value. 
  
 1.5 Expiry of Warrant. Except to the
extent it may expire with respect to certain shares of Warrant Stock as provided in this Section 1.5, this Warrant expires as to all shares of Warrant Stock on August 1, 2012. This Warrant is issued in connection with a loan made by Holder to the
Company pursuant to a Loan and Security Agreement of even date herewith (the “Loan Agreement”). This Warrant will expire with respect to 90,000 shares of Warrant Stock subject to this Warrant (the “Contingent Warrant Stock”), as
to 3,750 shares at midnight on the last day of each month during which there have been no borrowings outstanding under the Loan Agreement. A termination of the Loan Agreement by the Company other than during an Event of Default under the Loan
Agreement, shall cause this Warrant to expire with respect to Contingent Warrant Stock in an amount determined by multiplying 3,750 by the Remaining Monthly Periods. The “Remaining Monthly Periods” shall mean the number of full monthly
periods remaining through the Maturity Date set forth (and as defined) in the Loan Agreement plus the monthly period in which the termination of the Loan Agreement occurs if there have been no borrowings outstanding during such monthly period
through the date of termination. For example only, if the Loan Agreement is terminated by the Company after one year 
  

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 (other than as a result of an Event of Default under the Loan Agreement) and borrowings were outstanding during 6 of the
12 months of the term of the Loan Agreement, then the Warrant would have expired with respect to 3,750 shares of Contingent Warrant Stock at midnight on the last day of each of such 6 months during which borrowings were outstanding, and with respect
to 45,000 shares of Contingent Warrant Stock upon termination of the Loan. As a further example, if the Company had no borrowings outstanding at any time during months 2, 3, 4, 5, 7 and 23 of the Loan Agreement, then at midnight on the last day of
each of months 2, 3, 4, 5, 7 and 23, the Warrant would expire with respect to 3,750 shares of Contingent Warrant Stock, or an aggregate of 22,500 shares of Contingent Warrant Stock. Notwithstanding anything to the contrary set forth in this Warrant,
this Warrant is not exercisable with respect to any Contingent Warrant Stock until the risk of forfeiture with respect thereto has lapsed. 
  
 1.6 Automatic Conversion upon Expiration. In the event that, upon the Expiration Date, the fair market value of one share of Common Stock (or other
security issuable upon the exercise hereof) as determined in accordance with Section 1.3 above is greater than the Exercise Price in effect on such date, then this Warrant shall automatically be deemed on and as of such date to be converted pursuant
to Section 1.2 above as to all Warrant Stock (or such other securities) for which it shall not previously have been exercised or converted, and the Company shall promptly deliver a certificate representing the Warrant Stock (or such other
securities) issued upon such conversion to the Holder. 
  
 Section 2. Exchange
and Transfer of Warrant. 
  
 (a) This Warrant may be
transferred, in whole or in part, subject to (i) Holder’s compliance with the provisions of Section 6 hereof and (ii) the transferee holder of the new Warrant assumes in writing the obligations of the Holder set forth in the Agreement. A
transfer may be registered with the Company by submission to it of this Warrant, together with the annexed Assignment Form attached hereto as Exhibit B duly completed and executed. After the Company’s receipt of this Warrant and the Assignment
Form so completed and executed and compliance with Section 6 hereof, the Company will issue and deliver to the transferee a new warrant (representing the portion of this Warrant so transferred) at the same Exercise Price per share and otherwise
having the same terms and provisions as this Warrant, which the Company will register in the new holder’s name. In the event of a partial transfer of this Warrant, the Company shall concurrently issue and deliver to the transferring holder a
new warrant that entitles the transferring holder to purchase the balance of this Warrant not so transferred and that otherwise is upon the same terms and conditions as this Warrant. Upon the due delivery of this Warrant for transfer, the transferee
holder shall be deemed for all purposes to have become the holder of the new warrant issued for the portion of this Warrant so transferred, effective immediately prior to the close of business on the date of such delivery, irrespective of the date
of actual delivery of the new warrant representing the portion of this Warrant so transferred. 
  

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 (b) In the event of the loss, theft or destruction of this Warrant, the Company shall execute and deliver
an identical new warrant to the Holder in substitution therefor upon the Company’s receipt of (i) evidence reasonably satisfactory to the Company of such event and (ii) if requested by the Company, an indemnity agreement and, if requested, bond
reasonably satisfactory in form and substance to the Company. In the event of the mutilation of or other damage to the Warrant, the Company shall execute and deliver an identical new warrant to the Holder in substitution therefor upon the
Company’s receipt of the mutilated or damaged warrant. 
  
 (c) The Company shall pay all costs and expenses incurred in connection with the exercise, exchange, transfer or replacement of this Warrant, including, without limitation, the costs of preparation, execution and delivery of a new warrant
and of share certificates representing all Warrant Stock (but excluding any costs of a required indemnity or bond). 
  
 Section 3. Certain Covenants. 
  
 (a) The Company shall at all times reserve for issuance and keep available out of its authorized and unissued Common Stock, solely for the purpose of
providing for the exercise of this Warrant, such number of shares of Common Stock as shall from time to time be sufficient therefor. 
  
 (b) The Company will not, by amendment of its Certificate of Incorporation or Bylaws or through reorganization, consolidation, merger, amalgamation, sale
of assets or otherwise, avoid or seek to avoid the observance or performance of any of the terms of this Warrant. Without limiting the foregoing, the Company (i) will not increase the par value of any Warrant Stock receivable upon the exercise of
this Warrant above the amount payable therefor upon such exercise and (ii) will take all such action as may be necessary or appropriate in order that the Company may validly and legally issue fully paid and nonassessable shares upon the exercise of
this Warrant. 
  
 Section 4. Adjustments to Exercise Price and Number of Shares
of Warrant Stock. 
  
 4.1 Adjustments. In order to
prevent dilution of the rights granted hereunder, the Exercise Price shall be subject to adjustment from time to time in accordance with this Section 4. Upon each adjustment of the Exercise Price pursuant to this Section 4, the Holder shall
thereafter be entitled to acquire upon exercise, at the Exercise Price resulting from such adjustment, the number of shares of Common Stock of the Company obtainable by multiplying the Exercise Price in effect immediately prior to such adjustment by
the number of shares of Common Stock acquirable immediately prior to such adjustment and dividing the product thereof by the new Exercise Price resulting from such adjustment. 
  
 4.2 Subdivisions, Combinations and Share Dividends. If the Company shall at any time subdivide by split-up or
otherwise, its outstanding Common Stock into a greater 
  

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 number of shares, or issue additional Common Stock as a dividend, bonus issue or otherwise with respect to any Common
Stock, the Exercise Price in effect immediately prior to such subdivision or share dividend or bonus issue shall be proportionately reduced. Conversely, in case the outstanding Common Stock of the Company shall be combined into a smaller number of
shares, the Exercise Price in effect immediately prior to such combination shall be proportionately increased. 
  
 4.3. Reorganization, Reclassification, Consolidation, Merger or Sale of Assets. 
  
 (a) In the event of any reorganization, reclassification, consolidation or merger of the Company (other than a change in par
value, or from par value to no par value, or from no par value to par value, or as a result of a subdivision or combination provided for under Section 4.2, or other than a merger with another corporation in which the Company is the acquiring and the
surviving corporation and which does not result in any reclassification or change of outstanding securities issuable upon exercise of this Warrant, other than an Acquisition Transaction (as defined below)), as a condition to the completion of such
transaction the Company shall procure the issue of a new warrant to Holder for, or the Company shall make appropriate provision without the issuance of a new Warrant, so that the Holder shall have the right to receive upon exercise of this Warrant,
at a total purchase price not to exceed that payable upon the exercise of the unexercised portion of this Warrant, and in lieu of the shares of Common Stock theretofore issuable upon exercise of this Warrant, the number and kind of securities or
other property receivable upon such reclassification, reorganization, consolidation or merger by a holder of the number of shares of Common Stock then purchasable under this Warrant. 
  
 (b) Notwithstanding the provisions of Section 4.3(a), if the reorganization reclassification, consolidation or merger
constitutes an arm’s length transaction with a person not an Affiliate of the Company, where upon consummation of the transaction the holders of voting securities of the Company before the transaction do not hold a majority interest of the
outstanding voting securities of the entity surviving the transaction (an “Acquisition Transaction”), then, (i) if the consideration for such transaction is cash, the Warrant must be exercised prior to the closing of the transaction or the
Warrant will terminate upon such closing, (ii) if the consideration for such transaction is securities of the acquiring company and the acquiring company will not assume the Warrant as provided in Section 4.3(a) after the exercise of the
Company’s commercially reasonable efforts to cause such acquiring company to do so, then the Company will pay Holder the Formula Amount, which amount shall be paid upon consummation of such transaction and the Warrant shall terminate upon such
payment, or (iii) if the consideration for such transaction is cash and securities in the acquiring company, then the Warrant will be subject to the treatment described in clauses (i) and (ii) above, as applicable, as and when such cash and
securities are transferred to other Company stockholders. The Company shall give PFG the same notice of any such transaction as is required by law to be given to the holders of Common Stock of the Company. The “Formula Amount” shall be an
amount equal to the value of this Warrant or portion thereof, as applicable, determined using the 
  

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 Black-Scholes model of option valuation assuming that the Warrant had been assumed by the acquiring company and
determining volatility on an implied basis using pricing information for trading of options in the stock of the acquiring company as of the date of determination or, if no such pricing information is available, determining volatility on an
historical basis for the 12 month period prior to the date of determination. 
  
 (c) If the Warrant will be exercised in connection with an Acquisition Transaction pursuant to clauses (i) or (ii) of Section 4.3(b) and the number of shares for which this Warrant is exercisable has not yet been
fully determined pursuant to the terms of Section 1.5, then, so long as the Loan Agreement is terminated upon such Acquisition, the Contingent Warrant Stock shall be exercisable in connection with such Acquisition Transaction with respect to a
number of shares determined according to the following formula: 
  

					
	 X = 90,000 – A + (3,750 * (24 – B))

	
	 Where:

			
	 X
	  	=	  	The number of Contingent Warrant Shares that are exercisable
	 A
	  	=	  	The number of Contingent Warrant Shares with respect to which the Warrant has already expired pursuant to Section 1.5
	 B
	  	=	  	The number of full months elapsed since the date of this Warrant
	 *
	  	=	  	Multiplied by

  
 4.4. Notices of
Record Date, Etc. In the event that the Company: 
  
 (1)
declares any dividend upon its capital stock, whether payable in cash, property, stock or other securities and whether or not a regular cash dividend, or 
  
 (2) offers for sale to all of its existing holders of Common Stock any shares of any class or series of the Company’s capital stock or securities
exchangeable for or convertible into such capital stock, or 
  
 (3) effects or approves any reclassification, exchange, substitution or recapitalization of the capital stock of the Company, including any subdivision or combination of its outstanding capital stock, or consolidation or merger of the
Company with, or sale of all or substantially all of its assets to, another corporation, or to liquidate, dissolve or wind up (including an assignment for the benefit of creditors), 
  
 then, in connection with such event, the Company shall give to Holder: 
  
 (i) at least ten (10) days prior written notice of the date on which the books of the Company shall close or a record shall
be taken for such a dividend or offer in respect of the matters referred to in (1) or (2) above, or for determining rights to vote in respect of the matters referred to in (3) above; and 
  

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 (ii) in the case of the matters referred to in (3) above, at least ten (10) days prior written notice of
the date when the same shall take place. 
  
 Such notice in accordance with the
foregoing clause (i) shall also specify, in the case of any such dividend, the date on which the holders of capital stock shall be entitled thereto and the terms of such dividend, and such notice in accordance with clause (ii) shall also specify the
date on which the holders of capital stock shall be entitled to exchange their capital stock for securities or other property deliverable upon such reorganization, reclassification, exchange, substitution, consolidation, merger or sale, as the case
may be, and the terms of such exchange. Each such written notice shall be given by first class mail, postage prepaid, addressed to the holder of this Warrant at the address of Holder; and 
  
 4.5. Adjustment by Board of Directors. If any event occurs as to which, in the opinion of the Board of Directors of
the Company, the provisions of this Section 4 are not strictly applicable or if strictly applicable would not fairly protect the rights of the Holder in accordance with the essential intent and principles of such provisions, then the Board of
Directors shall make an adjustment in the application of such provisions, in accordance with such essential intent and principles, so as to protect such rights, but in no event shall any adjustment have the effect of increasing the aggregate
Exercise Price for all shares subject to this Warrant. 
  
 4.6.
Officers’ Statement as to Adjustments. Whenever the Exercise Price and/or number of shares of Warrant Stock subject to the Warrant is required to be adjusted as provided in Section 4, the Company shall forthwith file at each office
designated for the exercise of this Warrant a statement, signed by the Chief Executive Officer, Chief Financial Officer or any Vice President of the Company, showing in reasonable detail the facts requiring such adjustment, the Exercise Price and
number of issuable shares that will be effective after such adjustment; provided, however, such statement shall not be required to the extent the information requested in this Section 4.6 is available through the Company’s reports filed with
the Securities and Exchange Commission. If the information described in this Section 4.6 is readily available through the Company’s reports filed with the Securities and Exchange Commission, the Company shall not be required to provide a
separate notice of adjustment to the Holder; provided, however, if such information is not readily available through the Company’s reports filed with the Securities Exchange Commission and made public, the Company shall cause a notice setting
forth any such adjustments to be sent by mail, first class, postage prepaid, to the record Holder of this Warrant at its address appearing herein. If such notice relates to an adjustment resulting from an event referred to in Section 4.3, such
notice shall be included as part of the notice required under the provisions of Section 4.3. 
  
 4.7 Price-Based Antidilution. In the event the Company, within one year of the close of the Loan Agreement, issues additional shares of Common Stock or options, warrants or securities convertible into Common
Stock, at a price per share of 
  

 8 

 Common Stock less than the Exercise Price in effect immediately prior to such issuance, the Exercise Price shall be
automatically reduced to such lower price; provided, however, that no adjustment shall be made with respect to the following: (i) issuances of Common Stock and securities convertible into or exercisable for Common Stock by the Company
in accordance with past practice to its officers, directors, employees and consultants pursuant to duly-approved stock incentive plans, (ii) up to $7 million worth of Common Stock issued at not more than 15% (on an average basis) below the Exercise
Price for the purpose of the Company completing acquisitions of other entities or assets, and (iii) shares of Common Stock issuable upon the exercise of warrants granted in connection with equipment financings in the ordinary course of business.

  
 4.8 Issue of Securities other than Common Stock. In the
event that at any time, as a result of any adjustment made pursuant to Section 4, the Holder thereafter shall become entitled to receive any shares of the Company, other than Common Stock, thereafter the number of such other shares so receivable
upon exercise of this Warrant shall be subject to adjustment from time to time in a manner and on terms as nearly equivalent as practicable to the provisions with respect to the Common Stock contained in Section 4. 
  
 Section 5. Rights and Obligations of the Warrant Holder. 
  
 This Warrant shall not entitle the Holder to any rights of a holder of
Common Stock in the Company, provided, however, Holder shall be entitled to “piggyback” registration rights and certain related rights and obligations set forth in Sections 2.6, 2.8, 2.9, 2.10, 2.11, 2.13 and 2.15 of the
Company’s Amended and Restated Investors’ Rights Agreement of even date herewith (the “IRA”). By signing this Warrant, Holder acknowledges that it has received a copy of the IRA. For all purposes under the relevant sections of
the IRA, the Holder will be deemed a “Holder” as that term is defined in the IRA and the Warrant Stock will be deemed Registrable Securities as that term is defined in the IRA. 
  
 Section 6. Restrictive Stock Legend; Transfer Restrictions. 
  
 This Warrant and the Warrant Stock have not been registered under any securities laws. Accordingly, this Warrant shall bear
the legend on the first page hereof and any share certificates issued pursuant to the exercise of this Warrant shall (until receipt of an opinion of counsel in customary form that such legend is no longer necessary) bear the following legend:

  
 THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE
SECURITIES ACT OF 1933 (THE “ACT”), AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OF DISTRIBUTION THEREOF. NO SUCH SALE OR DISTRIBUTION MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION
STATEMENT 
  

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 RELATED THERETO OR AN OPINION OF COUNSEL IN CUSTOMARY FORM THAT SUCH REGISTRATION IS NOT REQUIRED UNDER
THE ACT. 
  
 With respect to any offer, sale or other disposition of this Warrant
or any shares of Warrant Stock acquired pursuant to the exercise of this Warrant, unless the Warrant or the shares of Warrant Stock may be resold pursuant to an effective registration statement, the Holder agrees to give written notice to the
Company prior thereto, describing briefly the manner thereof, together with a written opinion of counsel, or other evidence, to the effect that such offer, sale or other disposition may be effected without registration or qualification (under
Securities Act of 1933, as amended (“the Act”) as then in effect or any federal or state securities law then in effect) of this Warrant or such shares of Warrant Stock and indicating whether or not under the Act, this Warrant or
certificates for such shares of Warrant Stock to be sold or otherwise disposed of require any restrictive legend as to applicable restrictions on transferability in order to ensure compliance with such law. Upon receiving such written notice and
reasonably satisfactory opinion or other evidence, the Company, as promptly as practicable and in no event later than 3 business days, shall notify the Holder that the Holder may sell or otherwise dispose of this Warrant or such shares of Warrant
Stock, all in accordance with the terms of the notice delivered to the Company. If a determination has been made pursuant to this Section 6 that the opinion of counsel or other evidence is not reasonably satisfactory to the Company, the Company
shall so notify the Holder promptly with details thereof after such determination has been made. The Company may issue stop transfer instructions to its transfer agent in connection with such restrictions. 
  
 Section 7. Notices. 
  
 Any notice or other communication required or permitted to be given here shall be in writing and shall be effective (a) upon
hand delivery or delivery by e-mail or facsimile at the address or number designated below (if delivered on a business day during normal business hours where such notice is to be received) or the first business day following such delivery (if
delivered other than on a business day during normal business hours where such notice is to be received), or (b) on the third business day following the date of mailing by express courier service, fully prepaid, addressed to such address, or upon
actual receipt of such mailing, whichever shall first occur. The addresses for such communication shall be: 
  
 if to Holder, at 
  
 Partners for Growth, L.P. 
 180 Pacific Avenue

 San Francisco, California 94111 
 Attention: Lorraine Nield 
 Fax: (415) 781-0510 
 Email: lorraine@pfgrowth.com 
  

 10 

 with a copy to 
  

Benjamin Greenspan, Esq. 
 620 Laguna Road

 Mill Valley, CA 94941 
 Fax:
(415) 358-4780 
 Email: bg2@greenspan.org 
  
 or 
  
 if to the Company, at 
  
 Xenogen Corporation 
 860 Atlantic Avenue

 Alameda, CA 94502 
 Phone:
(510) 291-6100 Fax: (510) 291-6134 
 Email: jason.brady@xenogen.com 
  
 with a copy to: 
  
 Andy Hirsch 
 Wilson Sonsini Goodrich &
Rosati 
 650 Page Mill Road 
 Palo Alto, California 94304-1050 
 Phone: 650-493-9300 
 Fax: 650-493-6811 
 ahirsch@wsgr.com 
  
 Each party hereto may from time to time change its address for notices under this Section 7 by giving at least 10 calendar days’ notice
of such changes address to the other party hereto. 
  
 Section 8. Amendments
and Waivers. 
  
 This Warrant and any term hereof may be
changed, waived, discharged or terminated only by an instrument in writing signed by the party against which enforcement of such change, waiver, discharge or termination is sought. 
  
 Section 9. Applicable Law; Severability. 
  
 This Warrant shall be governed by and construed and enforced in accordance with the laws of the State of California. If any one or more of the provisions
contained in this Warrant, or any application of any provision thereof, shall be invalid, illegal, or unenforceable in any respect, the validity, legality and enforceability of the remaining provisions contained herein and all other applications of
any provision thereof shall not in any way be affected or impaired thereby. 
  

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 Section 10. Construction. 
  
 The terms of the Warrant Purchase Agreement to which this Warrant is attached as Exhibit 1 are incorporated by reference
herein. Terms used but not defined herein have the meaning set forth in the Warrant Purchase Agreement. 
  
 [SIGNATURE PAGE FOLLOWS] 
  

 12 

 Signature Page Warrant 
  
 IN WITNESS WHEREOF, the Company has caused this Warrant to be duly executed on the day and year first above written.

  

			
	COMPANY:
	
	Xenogen Corporation
		
	By:	 	 /s/ William A. Albright

	Name:	 	William A. Albright
	Title:	 	Senior Vice President and Chief Financial Officer
	  
 ACKNOWLEDGED AND AGREED:
  
 HOLDER:
  
 Partners for Growth, L.P.

  

			
	 By:
	 	 /s/ Andrew W. Kahn

	 	 	Andrew W. Kahn, Manager of
	 	 	Partners for Growth, LLC,
	 	 	Its General Partner

 Exhibit A 
  

			
	To:	  	Xenogen Corporation

  
 ELECTION TO EXERCISE

  
 1. The undersigned hereby exercises its right to subscribe for and purchase
                             fully paid, validly issued and nonassessable Shares covered by the
attached Warrant and tenders payment herewith in the amount of $                     in accordance with the terms thereof. 
  
 1. The undersigned hereby elects to convert the attached Warrant into fully paid, validly
issued and nonassessable Shares by Cashless Exercise in the manner specified in Section 1.3 of the attached Warrant. This conversion is exercised with respect to
                     of shares. 
  
 [Strike the paragraph above that does not apply.] 
  
 , and requests that certificates for such shares be issued in the name of, and delivered to: 
  
 _____________________ 
 _____________________ 
 _____________________ 
  

					
	Date:
                                       
 	 	 [Holder]

			
	 	 	By	 	  

	 	 	Name:	 	 
	 	 	Title:	 	 

 Exhibit B 
  
 ASSIGNMENT FORM 
  
 To:     Xenogen Corporation 
  

The undersigned hereby assigns and transfers this Warrant to 
  

	
	 ______________________________________________________________

	(Insert assignee’s social security or tax identification number)
	
	______________________________________________________________
	(Print or type assignee’s name, address and postal code)
	
	 ______________________________________________________________

	
	 ______________________________________________________________

	
	and irrevocably appoints
                                        
                                 to transfer this Warrant on the books of the
Company.

  
  
 Date:
                                 
  

			
	 Partners For Growth, L.P.

		
	 By
	 	  

	Name:	 	                , Manager of Partners for Growth, LLC,
	 	 	Its General PartnerAmended and Restated Loan and Security Agreement

 EXHIBIT 10.1 
  
 AMENDED AND RESTATED 
 LOAN AND SECURITY AGREEMENT 
  
 by and among 

 
 SILICON VALLEY BANK 
 3003 Tasman Drive 
 Santa Clara, CA 95054 
 Attn: Loan Services 
 (408) 496-2429 

 
  
 and 
  
  
 XENOGEN CORPORATION 
 860 Atlantic Avenue 
 Alameda, California 94501 
  
 and 
  
 XENOGEN BIOSCIENCES
CORPORATION 
 5 Cedar Brook Drive 
 Cranbury, New Jersey 08512 
  
 TOTAL CREDIT AMOUNT:
$13,000,000 

 TABLE OF CONTENTS 
  

									
	 	  	 	  	Page

	 1.
	  	ACCOUNTING AND OTHER TERMS	  	- 1 -
			
	 2.
	  	LOAN AND TERMS OF PAYMENT	  	- 1 -
				
	 	  	2.1	  	Credit Extensions	  	- 1 -
					
	 	  	 	  	2.1.1	  	Revolving Advances	  	- 2 -
					
	 	  	 	  	2.1.2	  	Cash Management Services Sublimit	  	- 2 -
					
	 	  	 	  	2.1.3	  	Letters of Credit Sublimit	  	- 2 -
				
	 	  	2.2	  	Overadvances	  	- 3 -
				
	 	  	2.3	  	Interest Rate, Payments	  	- 3 -
				
	 	  	2.4	  	Fees	  	- 3 -
			
	 3.
	  	CONDITIONS OF LOANS	  	- 3 -
				
	 	  	3.1	  	Conditions Precedent to initial Credit Extensions	  	- 3 -
				
	 	  	3.2	  	Conditions Precedent to all Credit Extensions	  	- 4 -
			
	 4.
	  	CREATION OF SECURITY INTEREST	  	- 4 -
				
	 	  	4.1	  	Grant of Security Interest	  	- 4 -
			
	 5.
	  	REPRESENTATIONS AND WARRANTIES	  	- 5 -
				
	 	  	5.1	  	Due Organization and Authorization	  	- 5 -
				
	 	  	5.2	  	Collateral	  	- 5 -
				
	 	  	5.3	  	Litigation	  	- 6 -
				
	 	  	5.4	  	No Material Adverse Change in Financial Statements	  	- 6 -
				
	 	  	5.5	  	Solvency	  	- 6 -
				
	 	  	5.6	  	Regulatory Compliance	  	- 6 -
				
	 	  	5.7	  	Subsidiaries	  	- 6 -
				
	 	  	5.8	  	Full Disclosure	  	- 7 -
			
	 6.
	  	AFFIRMATIVE COVENANTS	  	- 7 -
				
	 	  	6.1	  	Government Compliance	  	- 7 -
				
	 	  	6.2	  	Financial Statements, Reports, Certificates	  	- 7 -
				
	 	  	6.3	  	Inventory; Returns	  	- 8 -
				
	 	  	6.4	  	Taxes	  	- 8 -
				
	 	  	6.5	  	Insurance	  	- 8 -

  

 i 

 TABLE OF CONTENTS 
 (continued) 
  

							
	 	  	 	  	 	  	Page

	 	  	6.6	  	Accounts	  	- 9 -
				
	 	  	6.7	  	Notice of Management Change	  	- 9 -
				
	 	  	6.8	  	Remaining Months Liquidity	  	- 9 -
				
	 	  	6.9	  	Control Agreements	  	- 9 -
				
	 	  	6.10	  	Further Assurances	  	- 9 -
			
	 7.
	  	NEGATIVE COVENANTS	  	- 9 -
				
	 	  	7.1	  	Dispositions	  	- 9 -
				
	 	  	7.2	  	Changes in Business or Business Locations	  	- 10 -
				
	 	  	7.3	  	Mergers or Acquisitions	  	- 10 -
				
	 	  	7.4	  	Indebtedness	  	- 10 -
				
	 	  	7.5	  	Encumbrance	  	- 10 -
				
	 	  	7.6	  	Distributions; Investments	  	- 10 -
				
	 	  	7.7	  	Transactions with Affiliates	  	- 11 -
				
	 	  	7.8	  	Subordinated Debt	  	- 11 -
				
	 	  	7.9	  	Compliance	  	- 11 -
			
	 8.
	  	EVENTS OF DEFAULT	  	- 11 -
				
	 	  	8.1	  	Payment Default	  	- 11 -
				
	 	  	8.2	  	Covenant Default	  	- 12 -
				
	 	  	8.3	  	Material Adverse Change	  	- 12 -
				
	 	  	8.4	  	Attachment	  	- 12 -
				
	 	  	8.5	  	Insolvency	  	- 12 -
				
	 	  	8.6	  	Other Agreements	  	- 12 -
				
	 	  	8.7	  	Judgments	  	- 13 -
				
	 	  	8.8	  	Misrepresentations	  	- 13 -
				
	 	  	8.9	  	Guaranty	  	- 13 -
				
	 	  	8.10	  	Change of Control	  	- 13 -
			
	 9.
	  	BANK’S RIGHTS AND REMEDIES	  	- 13 -
				
	 	  	9.1	  	Rights and Remedies	  	- 13 -
				
	 	  	9.2	  	Power of Attorney	  	- 14 -
				
	 	  	9.3	  	Accounts Collection	  	- 14 -

  

 ii 

 TABLE OF CONTENTS 
 (continued) 
  

							
	 	  	 	  	 	  	Page

	 	  	9.4	  	Bank Expenses	  	- 15 -
				
	 	  	9.5	  	Bank’s Liability for Collateral	  	- 15 -
				
	 	  	9.6	  	Remedies Cumulative	  	- 15 -
				
	 	  	9.7	  	Demand Waiver	  	- 15 -
				
	 	  	9.8	  	Suretyship Waivers	  	- 15 -
				
	 	  	9.9	  	Right of Contribution	  	- 17 -
			
	 10.
	  	NOTICES	  	- 17 -
			
	 11.
	  	CHOICE OF LAW, VENUE AND JURY TRIAL WAIVER	  	- 17 -
			
	 12.
	  	GENERAL PROVISIONS	  	- 17 -
				
	 	  	12.1	  	Successors and Assigns	  	- 17 -
				
	 	  	12.2	  	Indemnification	  	- 18 -
				
	 	  	12.3	  	Time of Essence	  	- 18 -
				
	 	  	12.4	  	Severability of Provision	  	- 18 -
				
	 	  	12.5	  	Amendments in Writing, Integration	  	- 18 -
				
	 	  	12.6	  	Counterparts	  	- 18 -
				
	 	  	12.7	  	Survival	  	- 18 -
				
	 	  	12.8	  	Confidentiality	  	- 18 -
				
	 	  	12.9	  	Attorneys’ Fees, Costs and Expenses	  	- 19 -
				
	 	  	12.10	  	Replacement Loan Agreement	  	- 19 -
			
	 13.
	  	DEFINITIONS	  	- 19 -

  
  

 iii 

 This AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT dated August 2, 2005, among SILICON VALLEY BANK
(“Bank”), whose address is 3003 Tasman Drive, Santa Clara, California 95054 and XENOGEN CORPORATION (“Xenogen”), a Delaware corporation, whose address is 860 Atlantic Avenue, Alameda, California 94501 and XENOGEN
BIOSCIENCES CORPORATION (“XBC”), an Ohio corporation, whose address is 5 Cedar Brook Drive, Cranbury, New Jersey 08512 (individually each a “Borrower”, and separately and collectively, the
“Borrowers”) provides the terms on which Bank will lend to Borrowers and Borrowers will repay Bank. 
  
 RECITALS 
  
 A. Xenogen and Bank entered into a Loan and Security Agreement, dated September 10, 2003, which has been amended by that certain Loan Modification Agreement dated March 26, 2004, that certain Loan Modification
Agreement dated July 1, 2004, that certain Loan Modification Agreement dated September 30, 2004 and that certain Loan Modification Agreement dated March 31, 2005 (collectively referred to as the “Loan Agreement”). 
  
 B. Xenogen has requested that Bank amend the Loan Agreement to, among other
things, increase the available amount of credit, extend the Revolving Maturity Date and add XBC, its wholly owned subsidiary, as a borrower, and Bank is willing to do so on the terms and conditions set forth herein. 
  
 C. The parties desire to amend and restate herein the Loan Agreement in its
entirety to effectuate these changes and consolidate the prior modifications. 
  
 D. This Agreement shall amend, re-evidence, restate and supercede in full the Loan Agreement, but shall not evidence a novation or a release or relinquishment of the priority of the security interests granted in
connection with the Loan Agreement and the other Loan Documents and other documents executed in connection with the Loan Agreement; 
  
 NOW, THEREFORE, in consideration of the premises and the mutual promises herein contained, Borrowers and Bank agree as
follows: 
  
 1. ACCOUNTING AND OTHER TERMS. 
  
 Accounting terms not defined in this Agreement will be construed following
GAAP. Calculations and determinations must be made following GAAP. The term “financial statements” includes the notes and schedules. The terms “including” and “includes” always mean “including (or includes) without
limitation,” in this or any Loan Document. 
  
 2. LOAN AND TERMS OF
PAYMENT 
  
 2.1 Credit Extensions. 
  
 Borrowers will pay Bank the unpaid principal amount of all Credit Extensions
and interest on the unpaid principal amount of the Credit Extensions. 
  

 - 1 - 

 2.1.1 Revolving Advances. 
  
 (a) Bank will make advances to Borrowers as follows: 
  
 (i) Bank will make Advances not exceeding an aggregate of $13,000,000 (the “Committed Revolving Line”), minus (A) amounts deemed
outstanding under the Cash Management Services Sublimit, and minus (B) the amounts of all outstanding Letters of Credit (including drawn but unreimbursed Letters of Credit). 
  
 (ii) Amounts borrowed under this Section may be repaid and reborrowed during the term of this Agreement. 
  
 (iii) Borrower may terminate this Agreement at any time by: (1) providing
Bank with notice three (3) Business Days prior to such termination; (2) paying Bank all outstanding Obligations at such time (including principal and accrued interest); and (3) paying Bank a termination premium equal to the product of: (y) the
Minimum Interest (calculated using the Applicable Interest Rate in effect on the effective date of such termination) multiplied by (z) the number of full or partial months remaining from the effective date of such termination through the Revolving
Maturity Date. 
  
 (b) To obtain an Advance, Borrowers must notify
Bank by facsimile or telephone by 12:00 noon Pacific time on the Business Day the Advance is to be made. A Borrower must promptly confirm the notification by delivering to Bank the Payment/Advance Form attached as Exhibit B, which shall be binding
against both Borrowers and to the extent only signed by one Borrower, any representations made by the signing Borrower shall be deemed a representation made by the non-signing Borrower. Bank will credit Advances to the signing Borrower’s
deposit account. Each Advance must be in a minimum amount of $100,000. Bank may make Advances under this Agreement based on instructions from a Responsible Officer or his or her designee or without instructions if the Advances are necessary to meet
Obligations which have become due. Bank may rely on any telephone notice given by a person whom Bank believes is a Responsible Officer or designee. Borrower will indemnify Bank for any loss Bank suffers due to such reliance. 
  
 (c) The Committed Revolving Line terminates on the Revolving Maturity Date,
when all Advances are immediately payable. 
  
 2.1.2 Cash Management Services
Sublimit. 
  
 Borrowers may use up to Two Million Dollars
($2,000,000) for Bank’s Cash Management Services, which may include merchant services, direct deposit of payroll, business credit card, and check cashing services identified in various cash management services agreements related to such
services (the “Cash Management Services”). All amounts Bank pays for any Cash Management Services will be treated as Advances under the Committed Revolving Line. 
  

 - 2 - 

 2.1.3 Letters of Credit Sublimit. 
  
 Bank will issue or have issued Letters of Credit (“Letters of Credit”) for Borrowers’ account not
exceeding (i) the Committed Revolving Line, minus (ii) the outstanding principal balance of the Advances minus the Cash Management Sublimit; however, the face amount of outstanding Letters of Credit (including drawn but unreimbursed Letters
of Credit) may not exceed $2,000,000. Borrowers’ outstanding reimbursement obligation hereunder will be secured by unencumbered cash on terms acceptable to Bank at any time upon the Revolving Maturity Date if the term of this Agreement is not
extended by Bank. Borrowers agree to execute any further documentation in connection with the Letters of Credit as Bank may reasonably request. 
  
 2.2 Overadvances. 
  
 If Borrowers’ Obligations under Sections 2.1.1, 2.1.2, and 2.1.3 exceed the Committed Revolving Line, Borrowers must immediately pay Bank the excess.

  
 2.3 Interest Rate, Payments. 
  
 (a) Interest Rate. Advances accrue interest on the outstanding principal
balance at a per annum rate equal to the Applicable Interest Rate. The interest rate increases or decreases when the Prime Rate changes. Interest is computed on a 360 day year for the actual number of days elapsed. Commencing on June 30, 2004,
regardless of the amount of Advances that may be outstanding from time to time, Borrowers shall pay Bank on a monthly basis (and on the Revolving Maturity Date) during the term of this Agreement, the greater of (i) the actual interest accrued by the
Advances or (ii) the Minimum Interest. 
  
 (b) Payments. Interest
due on the Committed Revolving Line is payable on the first day of each month. Bank may debit any of Borrowers’ deposit accounts including Account Number 3300374106 for principal and interest payments owing or any amounts Borrowers owe Bank.
Bank will promptly notify Borrower when it debits Borrowers’ accounts. These debits are not a set-off. Payments received after 12:00 noon Pacific time are considered received at the opening of business on the next Business Day. When a payment
is due on a day that is not a Business Day, the payment is due the next Business Day and additional fees or interest accrue. 
  
 2.4 Fees. 
  
 Borrowers will pay: 
  
 (a) Loan Fee. Borrowers shall pay Bank a loan fee in the amount of $248,333, fully earned on the Closing Date and payable as follows: (i) $118,333 payable
on the Closing Date and (ii) $130,000 payable on the earlier of: (1) the first anniversary of the Closing Date or (2) the termination of this Agreement. A good faith deposit of $25,000 has already been paid to Bank and will be credited to the amount
due on the Closing Date. 
  
 (b) Intentionally Omitted.

  

 - 3 - 

 (c) Bank Expenses. All Bank Expenses incurred through and after the date of this Agreement, are payable
when due. 
  
 3. CONDITIONS OF LOANS 
  
 3.1 Conditions Precedent to continued Credit Extensions. 

 
 Bank’s obligation to continue making Credit Extensions is subject to
the following conditions precedent: 
  
 (a) receipt by Bank of
the each Borrower’s resolution authorizing the transaction in form and substance satisfactory to Bank; 
  
 (b) receipt by Bank of the Loan Fee due on the Closing Date; 
  
 (c) receipt by Bank of Xenogen’s consolidated financial projections approved by Xenogen’s Board of Directors; and 
  
 (d) receipt by Bank of all other agreement and documents that Bank may
reasonably require. 
  
 3.2 Conditions Precedent to all
Credit Extensions. 
  
 Bank’s obligations to make each
Credit Extension, including the initial Credit Extension, is subject to the following: 
  
 (a) timely receipt of any Payment/Advance Form; and 
  
 (b) the representations and warranties in Section 5 must be materially true on the date of the Payment/Advance Form and on the effective date of each Credit Extension and no Event of Default may have occurred and be
continuing, or result from the Credit Extension (provided, however, that those representations and warranties expressly referring to another date shall be materially true as of such date). Each Credit Extension is Borrower’s representation and
warranty on that date that the representations and warranties of Section 5 remain true. 
  
 4. CREATION OF SECURITY INTEREST 
  
 4.1
Grant of Security Interest. 
  
 Borrowers grant Bank a
continuing security interest in all presently existing and later acquired Collateral to secure all Obligations and performance of each Borrower’s material duties under the Loan Documents. Except for Permitted Liens, any security interest will
be a first priority security interest in the Collateral. Notwithstanding the foregoing, the security interest granted herein does not extend to and the term “Collateral” does not include any license or contract rights to the extent (i) the
granting of a security interest in it would be contrary to applicable law, or (ii) that such rights are nonassignable by their terms (but only to the extent 
  

 - 4 - 

 such prohibition is enforceable under applicable law, including, without limitation, Section 9406 of the Code) without
the consent of the licensor or other party (but only to the extent such consent has not been obtained). Except as disclosed on the Schedule, neither Borrower is a party to, nor is bound by, any material license or other similar agreement that
prohibits or otherwise restricts such Borrower from granting a security interest in such Borrower’s interest in such license or agreement or any other property. Without prior notice to Bank, neither Borrower shall enter into, or become bound
by, any such license or agreement which is reasonably likely to have a material impact on such Borrower’s business or financial condition. Borrowers shall take such steps as Bank requests to obtain the consent of, or waiver by, any person whose
consent or waiver is necessary for such licenses or contract rights to be deemed “Collateral” and for Bank to have a security interest in it that might otherwise be restricted or prohibited by law or by the terms of any such license or
agreement, whether now existing or entered into in the future. If this Agreement is terminated, Bank’s lien and security interest in the Collateral will continue until Borrowers fully satisfy their Obligations. Notwithstanding anything
contained in this Agreement to the contrary, the term Collateral shall not include any property that is subject to a Lien that is otherwise permitted pursuant to paragraph (c) of the definition of “Permitted Liens” and Bank agrees to
execute any instruments or documents necessary to release its interest in such property and to effect the foregoing. Bank agrees to terminate its security interest and any relating UCC-1 financing statements upon payment in full, in immediately
available funds, of the Obligations. 
  
 5. REPRESENTATIONS AND
WARRANTIES 
  
 Borrowers, jointly and severally, hereby
represent and warrant to Bank, as of the date hereof and as of the date of each Credit Extension that: 
  
 5.1 Due Organization and Authorization. 
  
 Each Borrower and each Subsidiary is duly existing and in good standing in its jurisdiction of formation and qualified and licensed to do business in, and
in good standing in, any state in which the conduct of its business or its ownership of property requires that it be qualified, except where the failure to do so could not reasonably be expected to cause a Material Adverse Change. 
  
 The execution, delivery and performance of the Loan Documents have been duly
authorized, and do not conflict with Borrowers’ formation documents, nor constitute an event of default under any material agreement by which either Borrower is bound. Borrowers are not in default under any agreement to which or by which it is
bound in which the default could reasonably be expected to cause a Material Adverse Change. 
  
 5.2 Collateral. 
  
 Borrowers have good title to the Collateral, free of Liens except Permitted Liens. Borrowers have no other deposit accounts, other than the deposit accounts described in the Schedule. The Accounts are bona fide, existing obligations, and
the service or property has been performed or delivered to the account debtor or its agent for immediate shipment to and 
  

 - 5 - 

 unconditional acceptance by the account debtor. The Collateral is not in the possession of any third party bailee (such
as at a warehouse). In the event that Borrowers, after the date hereof, intend to store or otherwise deliver the Collateral to such a bailee, then Borrowers will receive the prior written consent of Bank and such bailee must acknowledge in writing
that the bailee is holding such Collateral for the benefit of Bank. Neither Borrower has notice of any actual or imminent Insolvency Proceeding of any account debtor whose accounts are an Eligible Account. All Inventory is in all material respects
of good and marketable quality, free from material defects. 
  
 5.3 Litigation. 
  
 Except as shown in the
Schedule, there are no actions or proceedings pending or, to the knowledge of Borrowers’ Responsible Officers and legal counsel, threatened by or against Borrowers or any Subsidiary in which a likely adverse decision could reasonably be
expected to cause a Material Adverse Change. 
  
 5.4 No
Material Adverse Change in Financial Statements. 
  
 All
consolidated financial statements of Xenogen (which includes each Subsidiary), delivered to Bank fairly present in all material respects Xenogen’s consolidated financial condition and its consolidated results of operations. There has not been
any material deterioration in Xenogen’s consolidated financial condition since the date of the most recent financial statements submitted to Bank. 
  
 5.5 Solvency. 
  
 The fair salable value of each Borrower’s assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities; each
Borrower is not left with unreasonably small capital after the transactions in this Agreement; and each Borrower is able to pay its debts (including trade debts) as they mature. 
  
 5.6 Regulatory Compliance. 
  

Neither Borrower is an “investment company” or a company “controlled” by an “investment company” under the Investment
Company Act. Neither Borrower is engaged as one of its important activities in extending credit for margin stock (under Regulations T and U of the Federal Reserve Board of Governors). Borrowers have complied in all material respects with the Federal
Fair Labor Standards Act. Neither Borrower has violated any laws, ordinances or rules, the violation of which could reasonably be expected to cause a Material Adverse Change. None of Borrowers’ or any Subsidiary’s properties or assets has
been used by Borrowers or any Subsidiary or, to the best of Borrower’s knowledge, by previous Persons, in disposing, producing, storing, treating, or transporting any hazardous substance other than legally. Each Borrower and each Subsidiary has
timely filed all required tax returns and paid, or made adequate provision to pay, all material taxes, except those being contested in good faith with adequate reserves under GAAP. Each Borrower and each Subsidiary has obtained all consents,
approvals and authorizations of, made all declarations or filings with, and given all notices to, all government authorities that are necessary to continue its business as currently conducted, except where the failure to do so could not reasonably
be expected to cause a Material Adverse Change. 
  

 - 6 - 

 5.7 Subsidiaries. 
  
 Borrowers do not own any stock, partnership interest or other equity securities except for Permitted Investments.

  
 5.8 Full Disclosure. 
  
 No written representation, warranty or other statement of Borrowers in any
certificate or written statement given to Bank (taken together with all such written certificates and written statements to Bank) contains any untrue statement of a material fact or omits to state a material fact necessary to make the statements
contained in the certificates or statements not misleading. It being recognized by Bank that the projections and forecasts provided by Borrowers in good faith and based upon reasonable assumptions are not viewed as facts and that actual results
during the period or periods covered by such projections and forecasts may differ from the projected and forecasted results. 
  
 6. AFFIRMATIVE COVENANTS 
  
 On a continuing basis from the date of this Agreement until the Indebtedness is paid in full and Borrowers have performed all of their other obligations
hereunder and under each other Loan Document, Borrowers, jointly and severally, covenant and agree that: 
  
 6.1 Government Compliance. 
  
 Each Borrower will maintain its and all Subsidiaries’ legal existence and good standing in its jurisdiction of formation and maintain qualification
in each jurisdiction in which the failure to so qualify would reasonably be expected to cause a material adverse effect on either Borrower’s business or operations. Borrowers will comply, and have each Subsidiary comply, with all laws,
ordinances and regulations to which it is subject, noncompliance with which could have a material adverse effect on either Borrower’s business or operations or would reasonably be expected to cause a Material Adverse Change. 
  
 6.2 Financial Statements, Reports, Certificates. 
  
 (a) Xenogen will deliver to Bank: (i) as soon as available, but no later
than 30 days after the last day of each month, a company prepared consolidated balance sheet and income statement covering Xenogen’s consolidated operations during the period, in a form and certified by a Responsible Officer acceptable to Bank;
(ii) as soon as available, but no later than 120 days after the last day of Xenogen’s fiscal year, audited consolidated financial statements prepared under GAAP, consistently applied, together with an opinion that is unqualified (other than on
going concern qualification) or otherwise consented to by Bank on the financial statements from an independent certified public accounting firm reasonably acceptable to Bank; (iii) within 5 days of filing, copies of all statements, reports and
notices generally made available to each 
  

 - 7 - 

 Borrower’s security holders or to any holders of Subordinated Debt; (iv) a prompt report of any legal actions
pending or threatened against either Borrower or any Subsidiary that could result in damages or costs to such Borrower or any Subsidiary of $250,000 or more; (v) as soon as available, but no later than 45 days after the last day of each fiscal year
of Xenogen, Xenogen’s consolidated financial projections for the year approved by its Board of Directors; and (vi) budgets, sales projections, operating plans or other financial information Bank reasonably requests. To the extent available,
Xenogen may comply with the requirements in clauses (i), (ii) and (iii) above by delivering an email with a link to any of the required documents that have been publicly filed. 
  
 (b) Monthly, within 30 days after the last day of each month, Borrowers will deliver to Bank aged listings of accounts
receivable and accounts payable, and a detailed Deferred Revenue Schedule. 
  
 (c) Within 30 days after the last day of each month, Xenogen will deliver to Bank with the monthly consolidated financial statements a Compliance Certificate signed by a Responsible Officer in the form of Exhibit C.

  
 (d) Bank has the right to audit Borrower’s Collateral at
Borrowers’ expense, but the audits will be conducted no more often than once every year unless an Event of Default has occurred and is continuing. 
  
 6.3 Inventory; Returns. 
  
 Borrowers will keep all Inventory in good and marketable condition, free from material defects. Returns and allowances between any Borrower and its
account debtors will follow that Borrower’s customary practices as they exist at execution of this Agreement. Borrowers must promptly notify Bank of all returns, recoveries, disputes and claims, that involve more than $300,000 in the aggregate
in any one fiscal year. 
  
 6.4 Taxes. 
  
 Each Borrower will make, and cause each Subsidiary to make, timely payment
of all material federal, state, and local taxes or assessments, and will deliver to Bank, on demand, appropriate certificates attesting to the payment; provided that Borrowers or a Subsidiary need not make any payment if the amount or validity of
such payment is contested in good faith by appropriate proceedings and is reserved against to the extent required by GAAP. 
  
 6.5 Insurance. 
  
 Each Borrower will keep its business and the Collateral insured for risks and in amounts, as Bank may reasonably request. Insurance policies will be in a
form, with companies, and in amounts that are satisfactory to Bank in Bank’s reasonable discretion. All property policies will have a lender’s loss payable endorsement showing Bank as an additional loss payee and all liability policies
will show the Bank as an additional insured and provide that the insurer must give Bank at least 20 days notice before canceling its policy. At Bank’s request, Borrowers will 
  

 - 8 - 

 deliver certified copies of policies and evidence of all premium payments. If no Event of Default has occurred and is
continuing, proceeds payable under any casualty policy will, at Borrowers’ option, be payable to the affected Borrower to replace the property subject to the claim, provided that any such replacement property shall be deemed Collateral in which
Bank has been granted a first priority security interest. If an Event of Default has occurred and is continuing, then, at Bank’s option, proceeds payable under any policy will be payable to Bank on account of the Obligations. 

 
 6.6 Accounts. 
  
 Borrowers will maintain their primary operating accounts with Bank.
Additionally, each Borrower shall maintain no less than 85% of its cash and cash equivalents in deposit or investment accounts maintained at Bank or one of Bank’s Affiliates. 
  
 6.7 Notice of Management Change. 
  
 Borrowers shall notify Bank of the following parties separation from their employment at Xenogen within 30 days of such
separation: (i) David Carter, Pamela Contag, Ph.D., Anthony F. Purchio, Ph.D., William Albright. 
  
 6.8 Remaining Months Liquidity. 
  
 Xenogen will maintain, at all times, a Remaining Months Liquidity Ratio of at least (i) 4.0:1.0 until October 31, 2005 and (ii) 6.0:1.0 thereafter,
measured on a rolling three-month basis. 
  
 6.9 Control
Agreements. 
  
 With respect to deposit accounts or investment
accounts maintained at financial institutions other than Bank, within 15 days of the opening of any such deposit account or investment account (or of the Closing Date for any deposit accounts and investment accounts existing as of the Closing Date),
each Borrower will execute and deliver to Bank, control agreements in form satisfactory to Bank in order for Bank to perfect its security interest in each Borrower’s deposit accounts or investment accounts. Notwithstanding anything to the
contrary herein, Bank will not require a control agreement on Borrowers’ existing Bank of America account so long as within 30 days of the Closing Date, such account is either (i) closed or (ii) set-up as an overnight sweep account to
Borrowers’ primary operating account held with Bank. 
  
 6.10 Further Assurances. 
  
 Borrowers will
execute any further instruments and take further action as Bank reasonably requests to perfect or continue Bank’s security interest in the Collateral or to effect the purposes of this Agreement. 
  

 9 

 7. NEGATIVE COVENANTS 
  
 On a continuing basis from the date of this Agreement until the Indebtedness is paid in full and Borrowers have performed all of their other obligations
hereunder and under each other Loan Document, Borrowers, jointly and severally, covenant and agree that each Borrower, as appropriate will not do any of the following without Bank’s prior written consent, which will not be unreasonably
withheld: 
  
 7.1 Dispositions. 
  
 Convey, sell, lease, transfer or otherwise dispose of (collectively
“Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of its business or property, other than Transfers (i) of Inventory in the ordinary course of business (including Transfers of the IVIS systems); (ii) of
non-exclusive licenses and similar arrangements for the use of the property of Borrowers or its Subsidiaries in the ordinary course of business; (iii) of exclusive licenses of Intellectual Property entered into the ordinary course of business and
approved in good faith by such Borrower’s Board of Directors, so long as: (x) such licenses are limited to specific products or processes or a specific geographic area outside of the United States or Canada; (y) the duration of any such license
does not exceed 5 years; and (z) such exclusive license arrangement is not tantamount to a sale of the subject Intellectual Property; (iv) of worn-out or obsolete Equipment, (v) Transfers permitted by this Section 7, (vi) cross-licenses entered into
in settlement of litigation or potential litigation; or (vii) other Transfers which in the aggregate do not exceed $250,000 in any fiscal year. 
  
 7.2 Changes in Business or Business Locations. 
  
 Engage in or permit any of its Subsidiaries to engage in any business other than the businesses currently engaged in by Borrowers or reasonably related
thereto. Neither Borrower will, without at least 30 days prior written notice, relocate its chief executive office or add any new offices or business locations at which assets having a value in excess of $100,000 will be located. 
  
 7.3 Mergers or Acquisitions. 
  
 Merge or consolidate, or permit any of its Subsidiaries to merge or
consolidate, with any other Person, or acquire, or permit any of its Subsidiaries to acquire, all or substantially all of the capital stock or property of another Person, except (A) where (i) the aggregate purchase price or other consideration for
such transactions do not in the aggregate exceed $2,000,000 (provided however, that Borrowers may make a one-time acquisition valued at not more than $7,000,000 (exclusive of the $2,000,000 amount) where the consideration is not cash and Bank has
reviewed, and in its sole discretion, consented to the transaction), (ii) no Event of Default has occurred and is continuing or would result from such action during the term of this Agreement, (iii) a Borrower is the surviving entity after any such
acquisition (to the extent a Borrower was a party thereto), (iv) any single transaction does not result in a material reduction of either Borrower’s cash and cash equivalents or a material increase in Xenogen’s consolidated monthly cash
burn, and (v) such transaction would not result in a decrease of more than 25% of Tangible Net Worth, and (B) a Subsidiary may merge or consolidate into another Subsidiary or into a Borrower. 
  

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 7.4 Indebtedness. 
  
 Create, incur, assume, or be liable for any Indebtedness, or permit any Subsidiary to do so, other than Permitted
Indebtedness. 
  
 7.5 Encumbrance. 
  
 Create, incur, or allow any Lien on any of its property, or assign or convey
any right to receive income, including the sale of any Accounts, or permit any of its Subsidiaries to do so, except for Permitted Liens, or permit any Collateral not to be subject to the first priority security interest granted here, subject to
Permitted Liens. 
  
 7.6 Distributions; Investments.

  
 Directly or indirectly acquire or own any Person, or make any
Investment in any Person, other than Permitted Investments or as permitted by Section 7.3, or permit any of its Subsidiaries to do so. Pay any dividends (other than dividends payable solely in a Borrower’s capital stock or dividends payable by
XBC to Xenogen) or make any distribution or payment with respect to Xenogen’s capital stock or redeem, retire or purchase any of Xenogen’s capital stock except for (i) repurchases of stock from former employees, directors or service
providers of Borrowers under the terms of applicable repurchase agreements in an aggregate amount not to exceed $150,000 in the aggregate in any fiscal year, provided that no Event of Default has occurred, is continuing or would exist after giving
effect to the repurchases or (ii) the conversion by Xenogen of any of its convertible securities into other securities pursuant to the terms of such convertible securities or otherwise in exchange therefor, and payments in cash for any fractional
shares. 
  
 7.7 Transactions with Affiliates. 

 
 Directly or indirectly enter into or permit any material transaction with
any Affiliate, on terms less favorable to Borrowers than would be obtained in an arm’s length transaction with a non-affiliated Person, except transactions that are in the ordinary course of either Borrower’s business. 
  
 7.8 Subordinated Debt. 
  
 Make or permit any payment on any Subordinated Debt, except under the terms
of the Subordinated Debt, or amend any provision (other than an amendment extending the term of any such Subordinated Debt) in any document relating to the Subordinated Debt without Bank’s prior written consent. 
  

 - 11 - 

 7.9 Compliance. 
  
 Become an “investment company” or a company controlled by an “investment company,” under the Investment
Company Act of 1940 or undertake as one of its important activities extending credit to purchase or carry margin stock, or use the proceeds of any Credit Extension for that purpose; fail to meet the minimum funding requirements of ERISA, permit a
Reportable Event or Prohibited Transaction, as defined in ERISA, to occur; fail to comply with the Federal Fair Labor Standards Act or violate any other law or regulation, if the violation could reasonably be expected to have a material adverse
effect on Borrower’s business or operations or would reasonably be expected to cause a Material Adverse Change, or permit any of its Subsidiaries to do so. 
  

8. EVENTS OF DEFAULT 
  
 Any one of the following is an Event of Default: 
  
 8.1 Payment Default. 
  
 If Borrowers fail to pay any of the Obligations within 3 days after their due date. During the additional period the failure to cure the default is not an
Event of Default (but no Credit Extension will be made during the cure period); 
  
 8.2 Covenant Default. 
  
 If any Borrower does not perform any obligation in Section 6 or violates any covenant in Section 7 or does not perform or observe any other material term, condition or covenant in this Agreement, any Loan Documents, or in any agreement
between either Borrower and Bank and as to any default under a term, condition or covenant that can be cured, has not cured the default within 10 days after it occurs, or if the default cannot be cured within 10 days or cannot be cured after such
Borrower’s attempts within 10 day period, and the default may be cured within a reasonable time, then such Borrower has an additional period (of not more than 30 days) to attempt to cure the default. During the additional time, the failure to
cure the default is not an Event of Default (but no Credit Extensions will be made during the cure period); 
  
 8.3 Material Adverse Change. 
  
 If there (i) occurs a material adverse change in the business operations, or condition (financial or otherwise) of Borrowers taken together; or (ii) is a
material impairment of the prospect of repayment of any portion of the Obligations; or (iii) is a material impairment of the value or priority of Bank’s security interests in the Collateral (each a “Material Adverse Change”);

  

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 8.4 Attachment. 
  
 If any material portion of either Borrower’s assets is attached, seized, levied on, or comes into possession of a
trustee or receiver and the attachment, seizure or levy is not removed in 15 Business Days, or if either Borrower is enjoined, restrained, or prevented by court order from conducting a material part of its business or if a judgment or other claim
becomes a Lien on a material portion of such Borrower’s assets, or if a notice of lien, levy, or assessment is filed against any of Borrowers’ assets by any government agency and not paid within 15 Business Days after either Borrower
receives notice. These are not Events of Default if stayed or if a bond is posted pending contest by Borrowers (but no Credit Extensions will be made during the cure period); 
  
 8.5 Insolvency. 
  
 If either Borrower becomes insolvent or if either Borrower begins an Insolvency Proceeding or an Insolvency Proceeding is begun against a Borrower and not
dismissed or stayed within 45 days (but no Credit Extensions will be made before any Insolvency Proceeding is dismissed); 
  
 8.6 Other Agreements. 
  
 If there is a default in any agreement between either Borrower and a third party that gives the third party the right to accelerate any Indebtedness
exceeding $500,000 or that could cause a Material Adverse Change; 
  
 8.7 Judgments. 
  
 If a money judgment(s) in the
aggregate of at least $500,000 is rendered against either Borrower and is unsatisfied and unstayed for 10 days (but no Credit Extensions will be made before the judgment is stayed or satisfied); 
  
 8.8 Misrepresentations. 
  
 If either Borrower or any Responsible Officer makes any material
misrepresentation or material misstatement now or later in any warranty or representation in this Agreement or in any communication delivered to Bank or to induce Bank to enter this Agreement or any Loan Document; 
  
 8.9 Guaranty. 
  
 Any guaranty of any Obligations ceases for any reason to be in full force or
any Guarantor does not perform any obligation under any guaranty of the Obligations, or any material misrepresentation or material misstatement exists now or later in any warranty or representation in any guaranty of the Obligations or in any
certificate delivered to Bank in connection with the guaranty, or any circumstance described in Sections 8.4, 8.5 or 8.7 occurs to any Guarantor; or 
  

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 8.10 Change of Control. 
  
 If there shall be a Change of Control of Xenogen. 
  
 9. BANK’S RIGHTS AND REMEDIES 
  
 9.1 Rights and Remedies. 
  
 When an Event of Default occurs and continues Bank may, without notice or demand, do any or all of the following: 
  
 (a) Declare all Obligations immediately due and payable (but if an Event of
Default described in Section 8.5 occurs all Obligations are immediately due and payable without any action by Bank); 
  
 (b) Stop advancing money or extending credit for Borrowers’ benefit under this Agreement or under any other agreement between either Borrower and
Bank; 
  
 (c) Settle or adjust disputes and claims directly with
account debtors for amounts, on terms and in any order that Bank considers advisable; 
  
 (d) Make any payments and do any acts it considers necessary or reasonable to protect its security interest in the Collateral. Borrowers will assemble the Collateral if Bank requires and make it available as Bank
designates. Bank may enter premises where the Collateral is located, take and maintain possession of any part of the Collateral, and pay, purchase, contest, or compromise any Lien which appears to be prior or superior to its security interest and
pay all expenses incurred. Borrowers grant Bank a license to enter and occupy any of its premises, without charge, to exercise any of Bank’s rights or remedies; 
  
 (e) Bank may place a “hold” on any account maintained with Bank and deliver a notice of exclusive control, any
entitlement order, or other directions or instructions pursuant to any control agreement or similar agreements providing control of any Collateral. 
  
 (f) Apply to the Obligations any (i) balances and deposits of Borrowers it holds, or (ii) any amount held by Bank owing to or for the credit or the
account of Borrowers; 
  
 (g) Ship, reclaim, recover, store,
finish, maintain, repair, prepare for sale, advertise for sale, and sell the Collateral. Bank is granted a non-exclusive, royalty-free license or other right to use, without charge, Borrowers’ labels, Patents, Copyrights, Mask Works, rights of
use of any name, trade secrets, trade names, Trademarks, service marks, and advertising matter, or any similar property as it pertains to the Collateral, in completing production of, advertising for sale, and selling any Collateral and, in
connection with Bank’s exercise of its rights under this Section, Borrowers’ rights under all licenses and all franchise agreements inure to Bank’s benefit; and 
  

 - 14 - 

 (h) Dispose of the Collateral according to the Code. 
  
 9.2 Power of Attorney. 
  
 Effective only when an Event of Default occurs and continues, each Borrower
irrevocably appoints Bank as its lawful attorney to: (i) endorse such Borrower’s name on any checks or other forms of payment or security; (ii) sign such Borrower’s name on any invoice or bill of lading for any Account or drafts against
account debtors, (iii) make, settle, and adjust all claims under such Borrower’s insurance policies; (iv) settle and adjust disputes and claims about the Accounts directly with account debtors, for amounts and on terms Bank determines
reasonable; and (v) transfer the Collateral into the name of Bank or a third party as the Code permits. Bank may exercise the power of attorney to sign either Borrower’s name on any documents necessary to perfect or continue the perfection of
any security interest regardless of whether an Event of Default has occurred. Bank’s appointment as each Borrower’s attorney in fact, and all of Bank’s rights and powers, coupled with an interest, are irrevocable until all Obligations
have been fully repaid and performed and Bank’s obligation to provide Credit Extensions terminates. 
  
 9.3 Accounts Collection. 
  
 When an Event of Default occurs and continues, Bank may notify any Person owing either Borrower money of Bank’s security interest in the funds and
verify the amount of the Account. Upon the occurrence and during the continuance of an Event of Default, Borrowers must collect all payments in trust for Bank and, if requested by Bank, immediately deliver the payments to Bank in the form received
from the account debtor, with proper endorsements for deposit. 
  
 9.4 Bank Expenses. 
  
 If any Borrower fails to
pay any amount or furnish any required proof of payment to third persons, Bank may make all or part of the payment or obtain insurance policies required in Section 6.5, and take any action under the policies Bank deems prudent. Any amounts paid by
Bank are Bank Expenses and immediately due and payable, bearing interest at the then applicable rate and secured by the Collateral. No payments by Bank are deemed an agreement to make similar payments in the future or Bank’s waiver of any Event
of Default. 
  
 9.5 Bank’s Liability for Collateral.

  
 If Bank complies with reasonable banking practices and
Section 9-207 of the Code, it is not liable for: (a) the safekeeping of the Collateral; (b) any loss or damage to the Collateral; (c) any diminution in the value of the Collateral; or (d) any act or default of any carrier, warehouseman, bailee, or
other person. Borrower bears all risk of loss, damage or destruction of the Collateral. 
  

 - 15 - 

 9.6 Remedies Cumulative. 
  
 Bank’s rights and remedies under this Agreement, the Loan Documents, and all other agreements are cumulative. Bank has
all rights and remedies provided under the Code, by law, or in equity. Bank’s exercise of one right or remedy is not an election, and Bank’s waiver of any Event of Default is not a continuing waiver. Bank’s delay is not a waiver,
election, or acquiescence. No waiver is effective unless signed by Bank and then is only effective for the specific instance and purpose for which it was given. 
  

9.7 Demand Waiver. 
  
 Borrowers each waive demand, notice of default or dishonor, notice of payment and nonpayment, notice of any default, nonpayment at maturity, release,
compromise, settlement, extension, or renewal of accounts, documents, instruments, chattel paper, and guarantees held by Bank on which Borrowers are liable. 
  
 9.8 Suretyship Waivers. 
  
 Each Borrower hereby expressly waives (A) diligence, presentment, demand for payment, protest, benefit of any statute of limitations affecting such
Borrower’s liability under the Loan Documents; (B) discharge due to any disability of any Borrower; (C) any defenses of any Borrower to obligations under the Loan Documents not arising under the express terms of the Loan Documents or from a
material breach thereof by Borrower which under applicable law has the effect of discharging any Borrower from the Obligations as to which this Agreement is sought to be enforced; (D) the benefit of any act or omission by Borrower which directly or
indirectly results in or aids the discharge of any Borrower from any of the Obligations by operation of law or otherwise; (E) except as expressly provided herein, all notices whatsoever, including, without limitation, notice of acceptance of the
incurring of the Obligations; (F) any right it may have to require Borrower to disclose to it any information that Borrower may now or hereafter acquire concerning the financial condition or any circumstances that bears on the risk of nonpayment by
any other Borrower, including, without limitation, the release of such other Borrower from its Obligations hereunder; and (G) any requirement that Borrower exhaust any right, power or remedy or proceed against any other Borrower or any other
security for, or any guarantor of, or any other party liable for, any of the Obligations, or any portion thereof. Each Borrower specifically agrees that it shall not be necessary or required, and Borrowers shall not be entitled to require, that
Borrower (i) file suit or proceed to assert or obtain a claim for personal judgment against any other Borrower for all or any part of the Obligations; (ii) make any effort at collection or enforcement of all or any part of the Obligations from any
Borrower; (iii) foreclose against or seek to realize upon any security now or hereafter existing for all or any part of the Obligations; (iv) file suit or proceed to obtain or assert a claim for personal judgment against any Borrower or any
guarantor or other party liable for all or any part of the Obligations; (v) exercise or assert any other right or remedy to which Borrower is or may be entitled in connection with the Obligations or any security or guaranty relating thereto to
assert; or (vi) file any claim against assets of one Borrower before or as a condition of enforcing the liability of any other Borrower under this Agreement or the Notes. Without limiting the generality of the foregoing, each 
  

 - 16 - 

 Borrower expressly waives the benefit of California Civil Code Sections 2809, 2810, 2819, 2839, 2845, 2848 (until such
time as the Obligations are satisfied in full), 2849 (until such time as the Obligations are satisfied in full), 2850, 2899 and 1432. 
  
 WITHOUT LIMITING THE FOREGOING IN ANY WAY,
EACH BORROWER HEREBY IRREVOCABLY WAIVES AND RELEASES: 
  
 (a) Any and all rights it may have at any time (whether arising directly or indirectly, by operation of law, contract or
otherwise) to require the marshaling of any assets of any Borrower, which right of marshaling might otherwise arise from any such payments made or obligations performed; 
  
 (b) Until such time as the Obligations have been satisfied in full, any and all rights that would result in such Borrower
being deemed a “creditor” under the bankruptcy code of any other Borrower or any other person, on account of payments made or obligations performed by such Borrower; and 
  
 (c) Until such time as the Obligations have been satisfied in full, any claim, right or remedy which it may now have or
hereafter acquire against any other Borrower that arises hereunder and/or from the performance by it hereunder including, without limitation, any claim, remedy or right of subrogation, reimbursement, exoneration, contribution, indemnification or
participation in any claim, right or remedy of Bank against any other Borrower or any collateral security which Bank now have or may hereafter acquire, whether or not such claim, right or remedy arises in equity, under contract, by statute, under
common law or otherwise (including without limitation under section 9.9 hereof). 
  
 9.9 Right of Contribution. 
  
 Borrowers under this Agreement together desire to allocate among themselves, in a fair and equitable manner, the Obligations, provided that, with respect to a Borrower as of any date of determination, the largest amount that
may be borrowed by or allocated to such Borrower is an amount that would not render its Obligations subject to avoidance as a fraudulent transfer or conveyance under Section 548 of the Bankruptcy Code or any applicable provisions of comparable state
or foreign law. Solely for purposes of calculating the amount with respect to any Borrower for purposes of this Section 9.9, any assets or liabilities of such Borrower arising by virtue of any rights to subrogation, reimbursement or indemnification
or any rights to or obligations of contribution hereunder shall not be considered as assets or liabilities of such Borrower. The allocation among Borrowers of their obligations as set forth in this Section 9.9 shall not be construed in any way to
limit the liability of any Borrower hereunder or under any other Loan Document. 
  
 10. NOTICES 
  
 All notices or demands by any party
about this Agreement or any other related agreement must be in writing and be personally delivered or sent by an overnight delivery service, by certified mail, postage prepaid, return receipt requested, or by telefacsimile to the addresses set forth
at the beginning of this Agreement. A party may change its notice address by giving the other party written notice. 
  

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 11. CHOICE OF LAW, VENUE AND JURY TRIAL WAIVER 
  
 California law governs the Loan Documents without regard to principles of conflicts of law. Borrower and Bank each submit to
the exclusive jurisdiction of the State and Federal courts in Santa Clara County, California. 
  
 BORROWER AND BANK EACH WAIVE THEIR RIGHT TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION ARISING OUT OF ANY OF THE LOAN DOCUMENTS OR ANY CONTEMPLATED TRANSACTION, INCLUDING CONTRACT, TORT, BREACH OF DUTY AND ALL
OTHER CLAIMS. THIS WAIVER IS A MATERIAL INDUCEMENT FOR BOTH PARTIES TO ENTER INTO THIS AGREEMENT. EACH PARTY HAS REVIEWED THIS WAIVER WITH ITS COUNSEL. 
  
 12. GENERAL PROVISIONS 
  
 12.1 Successors and Assigns. 
  
 This Agreement binds and is for the benefit of the successors and permitted assigns of each party. Borrowers may not assign this Agreement or any rights
under it without Bank’s prior written consent which may be granted or withheld in Bank’s discretion. Bank has the right, without the consent of or notice to Borrowers, to sell, transfer, negotiate, or grant participation in all or any part
of, or any interest in, Bank’s obligations, rights and benefits under this Agreement. 
  
 12.2 Indemnification. 
  
 Each Borrower will indemnify, defend and hold harmless Bank and its officers, employees, and agents against: (a) all obligations, demands, claims, and liabilities asserted by any other party in connection with the transactions contemplated
by the Loan Documents, except for obligations, demands, claims, and liabilities caused by Bank’s gross negligence or willful misconduct; and (b) all losses or Bank Expenses incurred, or paid by Bank from, following, or consequential to
transactions between Bank and either Borrower (including reasonable attorneys fees and expenses), except for losses and Bank Expenses caused by Bank’s gross negligence or willful misconduct. 
  
 12.3 Time of Essence. 
  
 Time is of the essence for the performance of all obligations in this
Agreement. 
  
 12.4 Severability of Provision. 

 
 Each provision of this Agreement is severable from every other provision
in determining the enforceability of any provision. 
  

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 12.5 Amendments in Writing, Integration. 
  
 All amendments to this Agreement must be in writing and signed by Borrowers
and Bank. This Agreement represents the entire agreement about this subject matter, and supersedes prior negotiations or agreements, other than the Non-Disclosure Agreement, dated as of June 30, 2004. All prior agreements, understandings,
representations, warranties, and negotiations between the parties about the subject matter of this Agreement merge into this Agreement and the Loan Documents, other than the Non-Disclosure Agreement, dated as of June 30, 2004. 
  
 12.6 Counterparts. 
  
 This Agreement may be executed in any number of counterparts and by
different parties on separate counterparts, each of which, when executed and delivered, are an original, and all taken together, constitute one Agreement. 
  
 12.7 Survival. 
  
 All covenants, representations and warranties made in this Agreement continue in full force while any Obligations remain outstanding. The obligations of
Borrowers in Section 12.2 to indemnify Bank will survive until all statutes of limitations for actions that may be brought against Bank have run. 
  
 12.8 Confidentiality. 
  
 In handling any confidential information, Bank will exercise the same degree of care that it exercises for its own proprietary information, but disclosure
of information may be made (i) to Bank’s subsidiaries or affiliates in connection with their present or prospective business relations with Borrower, (ii) to prospective transferees or purchasers of any interest in the loans, (iii) as required
by law, regulation, subpoena, or other order, (iv) as required in connection with Bank’s examination or audit and (v) as Bank considers appropriate in exercising remedies under this Agreement. Confidential information does not include
information that either: (a) is in the public domain or in Bank’s possession when disclosed to Bank, or becomes part of the public domain after disclosure to Bank; or (b) is disclosed to Bank by a third party, if Bank does not know that the
third party is prohibited from disclosing the information. 
  
 12.9 Attorneys’ Fees, Costs and Expenses. 
  
 In any action or proceeding between Borrowers and Bank arising out of the Loan Documents, the prevailing party will be entitled to recover its reasonable attorneys’ fees and other reasonable costs and expenses incurred, in addition to
any other relief to which it may be entitled. 
  
 12.10
Replacement Loan Agreement. 
  
 So long as no Event of
Default has occurred and is continuing, upon the occurrence of a Threshold Event, Bank and Borrowers agree that this Agreement shall automatically be deemed 
  

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 amended, restated and superseded by that certain Loan and Security Agreement attached as Exhibit D (the “New
Agreement”). Borrowers agree to take any actions requested by Bank to fulfill the terms of this paragraph, but agree that, so long as no Event of Default has occurred and is continuing, the New Agreement shall be effective automatically without
further action by Borrowers. 
  
 13. DEFINITIONS 
  
 In this Agreement: 
  
 “Accounts” are all existing and later arising accounts,
contract rights, and other obligations owed either Borrower in connection with its sale or lease of goods (including licensing software and other technology) or provision of services, all credit insurance, guaranties, other security and all
merchandise returned or reclaimed by either Borrower and such Borrower’s Books relating to any of the foregoing. 
  
 “Applicable Interest Rate” is a per annum rate equal to the greater of: (i) 150 basis points (1.50%) above the Prime Rate or (ii) five
and one half percent (5.5%). Upon the occurrence and during the continuance of an Event of Default, the Applicable Interest Rate shall be 5 percent above the rate effective immediately before the applicable Event of Default. 
  
 “Advance” or “Advances” is a loan advance
(or advances) under the Committed Revolving Line. 
  
 “Affiliate” of a Person is a Person that owns or controls directly or indirectly the Person, any Person that controls or is controlled by or is under common control with the Person, and each of that Person’s senior
executive officers, directors, partners and, for any Person that is a limited liability company, that Person’s managers and members. 
  
 “Bank Expenses” are all audit fees and expenses and reasonable costs and expenses (including reasonable attorneys’ fees and
expenses) for preparing, negotiating, administering, defending and enforcing the Loan Documents (including appeals or Insolvency Proceedings). 
  
 “Borrower’s Books” are, as to each Borrower, all such Borrower’s books and records including ledgers, records regarding such
Borrower’s assets or liabilities, the Collateral, business operations or financial condition and all computer programs or discs or any equipment containing the information. 
  
 “Business Day” is any day that is not a Saturday, Sunday or a day on which the Bank is closed. 

 
 “Change in Control” is a transaction in which any
“person” or “group” (within the meaning of Section 13(d) and 14(d)(2) of the Securities Exchange Act of 1934, as amended (the “Act”)) becomes the “beneficial owner” (as defined in Rule 13d-3 under the
Act), directly or indirectly, of greater than 50% of the shares of all classes of stock then outstanding of Xenogen ordinarily entitled to vote in the election of directors. 
  

 - 20 - 

 “Closing Date” is the date of this Agreement. 
  
 “Code” is the California Uniform Commercial Code as amended,
revised and supplemented from time to time. 
  
 “Collateral” is the property described on Exhibit A. 
  
 “Committed Revolving Line” is as defined in Section 2.1.1(a) hereof. 
  
 “Contingent Obligation” is, for any Person, any direct or indirect liability, contingent or not, of that Person for (i) any indebtedness,
lease, dividend, letter of credit or other obligation of another such as an obligation directly or indirectly guaranteed, endorsed, co-made, discounted or sold with recourse by that Person, or for which that Person is directly or indirectly liable;
(ii) any obligations for undrawn letters of credit for the account of that Person; and (iii) all obligations from any interest rate, currency or commodity swap agreement, interest rate cap or collar agreement, or other agreement or arrangement
designated to protect a Person against fluctuation in interest rates, currency exchange rates or commodity prices; but “Contingent Obligation” does not include endorsements in the ordinary course of business. The amount of a Contingent
Obligation is the stated or determined amount of the primary obligation for which the Contingent Obligation is made or, if not determinable, the maximum reasonably anticipated liability for it determined by the Person in good faith; but the amount
may not exceed the maximum of the obligations under the guarantee or other support arrangement. 
  
 “Copyrights” are all copyright rights, applications or registrations and like protections in each work or authorship or derivative work,
whether published or not (whether or not it is a trade secret) now or later existing, created, acquired or held. 
  
 “Credit Extension” is each Advance, Letter of Credit or any other extension of credit by Bank for Borrower’s benefit. 
  
 “Deferred Revenue” is all amounts received in advance of
performance under a contract and not yet recognized as revenue. 
  
 “Eligible Accounts” are, as to each Borrower, Accounts in the ordinary course of such Borrower’s business that meet all such Borrower’s representations and warranties in Section 5; but Bank may change
eligibility standards by giving a Borrower notice. Unless Bank agrees otherwise in writing, Eligible Accounts will not include: 
  
 (a) Accounts that the account debtor has not paid within 90 days of invoice date; 
  
 (b) Accounts for an account debtor, 50% or more of whose Accounts have not been paid within 90 days of invoice date;

  
 (c) Credit balances over 90 days from invoice date;

  

 - 21 - 

 (d) Accounts for an account debtor, including Affiliates, whose total obligations to either Borrower
exceed 25% of all such Borrower’s Accounts, for the amounts that exceed that percentage, unless the Bank approves in writing; 
  
 (e) Accounts for which the account debtor does not have its principal place of business in the United States; 
  
 (f) Accounts for which the account debtor is a federal, state or local
government entity or any department, agency, or instrumentality; 
  
 (g) Accounts for which either Borrower owes the account debtor, but only up to the amount owed (sometimes called “contra” accounts, accounts payable, customer deposits or credit accounts); 
  
 (h) Accounts for demonstration or promotional equipment, or in which goods
are consigned, sales guaranteed, sale or return, sale on approval, bill and hold, or other terms if account debtor’s payment may be conditional; 
  
 (i) Accounts for which the account debtor is either Borrower’s Affiliate, officer, employee, or agent; 
  
 (j) Accounts in which the account debtor disputes liability or makes any
claim and Bank believes there may be a basis for dispute (but only up to the disputed or claimed amount), or if the account debtor is subject to an Insolvency Proceeding, or becomes insolvent, or goes out of business; 
  
 (k) Accounts with respect to which the goods giving rise to such Accounts
have not been shipped and billed to the account debtor, the services giving rise to such Account have not been performed and accepted by the account debtor, or the Account does not otherwise represent a final sale; 
  
 (l) Accounts that represent progress payments or other advance billings that
are due prior to the completion of performance by Borrower of the subject contract for goods or services; and 
  
 (m) Accounts for which Bank reasonably determines collection to be doubtful. 
  
 “Equipment” is all present and future machinery, equipment, tenant improvements, furniture, fixtures,
vehicles, tools, parts and attachments in which either Borrower has any interest. 
  
 “ERISA” is the Employment Retirement Income Security Act of 1974, and its regulations. 
  
 “GAAP” is generally accepted accounting principles. 
  

 - 22 - 

 “Guarantor” is any present or future guarantor of the Obligations. 
  
 “Indebtedness” is (a) indebtedness for borrowed money or the
deferred price of property or services, such as reimbursement and other obligations for surety bonds and letters of credit, (b) obligations evidenced by notes, bonds, debentures or similar instruments, (c) capital lease obligations and (d)
Contingent Obligations. 
  
 “Insolvency
Proceeding” are proceedings by or against any Person under the United States Bankruptcy Code, or any other bankruptcy or insolvency law, including assignments for the benefit of creditors, compositions, extensions generally with its
creditors, or proceedings seeking reorganization, arrangement, or other relief. 
  
 “Intellectual Property” is: 
  
 (a) Copyrights, Trademarks, and Patents including amendments, renewals, extensions, and all licenses or other rights to use and all license fees and royalties from the use; 
  
 (b) Any trade secrets and any intellectual property rights in computer
software and computer software products now or later existing, created, acquired or held; 
  
 (c) All design rights which may be available to either Borrower now or later created, acquired or held; 
  
 (d) Any claims for damages (past, present or future) for infringement of any of the rights above, with the right, but not the obligation, to sue and
collect damages for use or infringement of the intellectual property rights above; 
  
 All proceeds and products of the foregoing, including all insurance, indemnity or warranty payments. 
  
 “Inventory” is, with respect to each Borrower, present and future inventory in which Borrower has any interest, including merchandise,
raw materials, parts, supplies, packing and shipping materials, work in process and finished products intended for sale or lease or to be furnished under a contract of service, of every kind and description now or later owned by or in the custody or
possession, actual or constructive, of such Borrower, including inventory temporarily out of its custody or possession or in transit and including returns on any accounts or other proceeds (including insurance proceeds) from the sale or disposition
of any of the foregoing and any documents of title. 
  
 “Investment” is any beneficial ownership of (including stock, partnership interest or other securities) any Person, or any loan, advance or capital contribution to any Person. 
  
 “Lien” is a mortgage, lien, deed of trust, charge, pledge,
security interest or other encumbrance. 
  

 - 23 - 

 “Loan Documents” are, collectively, this Agreement, any note, or notes or guaranties
executed by either Borrower or Guarantor, and any other present or future agreement between Borrower and/or for the benefit of Bank in connection with this Agreement, all as amended, extended or restated. 
  
 “Material Adverse Change” is defined in Section 8.3.

  
 “Minimum Interest” is an amount equal to the
interest accrued (at the Applicable Interest Rate) if $8,000,000 of Advances were outstanding every day of the month immediately prior to the applicable interest payment date; provided, that, for the period commencing on the date of this Agreement
to September 30, 2005, “Minimum Interest” shall be an amount equal to the interest accrued (at the Applicable Interest Rate) if $6,500,000 of Advances were outstanding every day of the month immediately prior to the applicable interest
payment date. 
  
 “Modified Quick Ratio” means a
ratio of unrestricted cash (and equivalents) maintained at Bank or one of its Affiliates (measured at any time) plus, Eligible Accounts plus the PFG Availability (both as measured by the most recently delivered Compliance Certificate) divided by the
then total outstandings under all Credit Extensions. 
  
 “Obligations” are debts, principal, interest, Bank Expenses and other amounts Borrowers owe Bank now or later, including cash management services, letters of credit and foreign exchange contracts, if any and including
interest accruing after Insolvency Proceedings begin and debts, liabilities, or obligations of either Borrower assigned to Bank. 
  
 “Patents” are patents, patent applications and like protections, including improvements, divisions, continuations, renewals, reissues,
extensions and continuations-in-part of the same. 
  
 “Permitted Indebtedness” is: 
  
 (e)
Borrowers’ indebtedness to Bank under this Agreement or any other Loan Document; 
  
 (f) Indebtedness existing on the Closing Date and shown on the Schedule; 
  
 (g) Subordinated Debt; 
  
 (h) Indebtedness to trade creditors incurred in the ordinary course of business; 
  
 (i) Indebtedness secured by Permitted Liens; 
  
 (j) (i) Indebtedness of a Borrower to the other Borrower and Contingent Obligations of any Borrower with respect to
obligations of the other Borrower (provided that the primary obligations are not prohibited hereby), (ii) Indebtedness of Xenogen to any other Subsidiary and Contingent Obligations of any other Subsidiary with respect to obligations of Xenogen
(provided that the primary obligations are not prohibited hereby), and Indebtedness of any Subsidiary to any other Subsidiary and Contingent Obligations of any Subsidiary with respect to obligations of any other Subsidiary (provided that the primary
obligations are not prohibited hereby); 
  

 - 24 - 

 (k) Other Indebtedness not otherwise permitted by Section 7.4 not exceeding One Hundred Fifty Thousand
Dollars ($150,000) in the aggregate outstanding at any time; and 
  
 (l) Extensions, refinancings, modifications, amendments and restatements of any items of Permitted Indebtedness (a) through (f) above, provided that the principal amount thereof is not increased or the terms thereof are not modified to
impose more burdensome terms upon Borrowers or their Subsidiary, as the case may be. 
  
 “Permitted Investments” are: 
  
 (m) Investments shown on the Schedule and existing on the Closing Date; 
  
 (n) Marketable direct obligations issued or unconditionally guaranteed by the United States or its agency or any State maturing within 1 year from its
acquisition, (ii) commercial paper maturing no more than 1 year after its creation and having the highest rating from either Standard & Poor’s Corporation or Moody’s Investors Service, Inc., and (iii) Bank’s certificates of
deposit issued maturing no more than 1 year after issue, and (iv) any Investments permitted by Xenogen’s investment policy, as amended from time to time, provided that such investment policy (and any such amendment thereto) has been
approved by Bank; 
  
 (o) Investments consisting of the
endorsement of negotiable instruments for deposit or collection or similar transactions in the ordinary course of either Borrower; 
  
 (p) Investments accepted in connection with Transfers permitted by Section 7.1; 
  
 (q) Investments by a Borrower in or to another Borrower; Investments of Subsidiaries in or to other Subsidiaries or
Borrowers; and Investments by Borrowers in Subsidiaries that are not a Borrower, in all cases, not to exceed $250,000 in the aggregate in any fiscal year; 
  
 (r) Investments consisting of (i) travel advances and employee relocation loans and other employee loans and advances in the ordinary course of business
not to exceed $250,000 in any one fiscal year or $300,000 at any one time outstanding, and (ii) loans to employees, officers or directors or other service providers relating to the purchase of equity securities of either Borrower or its Subsidiaries
pursuant to employee stock purchase plans or agreements approved by Xenogen’s Board of Directors; 
  
 (s) Investments (including debt obligations) received in connection with the bankruptcy or reorganization of customers or suppliers and in settlement of
delinquent obligations of, and other disputes with, customers or suppliers arising in the ordinary course of business; 
  

 - 25 - 

 (t) Investments consisting of notes receivable of, or prepaid royalties and other credit extensions, to
customers and suppliers who are not Affiliates, in the ordinary course of business; provided that this paragraph (h) shall not apply to Investments of Borrowers in any Subsidiary; 
  
 (u) Investments pursuant to investment policy guidelines approved by Xenogen’s Board of Directors and Bank set forth
Exhibit E ; and 
  
 (v) Joint ventures or strategic alliances in
the ordinary course of either Borrower’s business consisting of the non-exclusive licensing of technology, the development of technology or the providing of technical support, provided that any cash investments by Borrowers do not exceed
$50,000 in the aggregate in any fiscal year. 
  
 “Permitted Liens” are: 
  
 (w) Liens
existing on the Closing Date and shown on the Schedule or arising under this Agreement or other Loan Documents; 
  
 (x) Liens for taxes, fees, assessments or other government charges or levies, either not delinquent or being contested in good faith and for which each
Borrower maintains adequate reserves on its Books, if they have no priority over any of Bank’s security interests; 
  
 (y) Purchase money Liens (i) on Equipment acquired or held by either Borrower or its Subsidiaries incurred for financing the acquisition of the Equipment,
or (ii) existing on equipment when acquired, if the Lien is confined to the property and improvements and the proceeds of the equipment; 
  
 (z) Licenses or sublicenses granted in the ordinary course of either Borrower’s business and any interest or title of a licensor or under any license
or sublicense; 
  
 (aa) Leases or subleases granted in the
ordinary course of either Borrower’s business, including in connection with such Borrower’s leased premises or leased property; 
  
 (bb) Liens incurred in the extension, renewal or refinancing of the indebtedness secured by Liens described in (a) through (c), but any extension,
renewal or replacement Lien must be limited to the property encumbered by the existing Lien and the principal amount of the indebtedness may not increase; 
  
 (cc) Liens arising from judgments, decrees or attachments in circumstances not constituting an Event of Default under
Section 8.4 or 8.7; 
  
 (dd) Liens in favor of other financial
institutions arising in connection with Borrowers’ deposit accounts held at such institutions, provided that Bank has a perfected security interest in the amounts held in such deposit accounts; 
  
 (ee) Carriers’, warehousemen’s, mechanics’,
materialmen’s, repairmen’s or other like Liens arising in the ordinary course of business which are not overdue for a period of more than 30 days or which are being contested in good faith and by appropriate proceedings if adequate
reserves with respect thereto are maintained on the books of the applicable Person; 
  

 - 26 - 

 (ff) Liens to secure payment of workers’ compensation, employment insurance, old age pensions,
social security or other like obligations incurred in the ordinary course of business; 
  
 (gg) Easements, rights-of-way, restrictions and other similar encumbrances affecting real property which, in the aggregate, are not substantial in amount, and which do not in any case materially detract from the value
of the property subject thereto or materially interfere with the ordinary conduct of the business of the applicable Person; and 
  
 (hh) Liens in favor of customs and revenue authorities arising as a matter of law to secure payment of customs duties in connection with the importation
of goods. 
  
 “Person” is any individual, sole
proprietorship, partnership, limited liability company, joint venture, company association, trust, unincorporated organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or
government agency. 
  
 “PFG Availability” means
the amount available to Borrower to borrow under that certain Loan and Security Agreement dated as of August 2, 2005 between Xenogen, XBC and Partners for Growth, L.P. 
  
 “Prime Rate” is Bank’s most recently announced “prime rate,” even if it is not Bank’s
lowest rate. 
  
 “R&D Collaboration” is a
transaction whereby an R&D Party provides a Borrower with cash for the purpose of a research and development collaboration. 
  
 “R&D Deferred Revenue” is cash received by a Borrower from an R&D Party that due to the structure of the applicable R&D
Collaboration is reflected as Deferred Revenue in that Borrower’s books. 
  
 “R&D Party” is any Person that enters into an R&D Collaboration with a Borrower. 
  
 “Remaining Months Liquidity Ratio” means a ratio of (i) (x) Xenogen’s consolidated unrestricted cash (and equivalents) maintained at
Bank or one of its Affiliates plus (measured at any time) (y) 80% of Eligible Accounts (based on the most recent Compliance Certificate) minus any Obligations hereunder to (ii) Xenogen’s consolidated net income plus depreciation and
amortization expenses (based on the most recent Compliance Certificate); provided, that, if Xenogen’s Modified Quick Ratio is equal to or greater than 2.0:1.0, then the amount in clause (i)(y) shall not be less than 0 for the purposes of
calculating Remaining Months Liquidity Ratio. 
  
 “Responsible Officer” is, as to each Borrower, each of the Chief Executive Officer, the President, the Chief Financial Officer, Vice President of Finance and the Controller of that Borrower. 
  

 - 27 - 

 “Revolving Maturity Date” is August 2, 2007. 
  
 “Schedule” means that certain confidential letter of
exceptions delivered by Borrowers to Bank on or about the date hereof. 
  
 “Subordinated Debt” is debt incurred by a Borrower subordinated to Borrowers’ indebtedness owed to Bank and which is reflected in a written agreement in a manner and form acceptable to Bank and approved by Bank in
writing. 
  
 “Subsidiary” is for any Person, or
any other business entity of which more than 50% of the voting stock or other equity interests is owned or controlled, directly or indirectly, by the Person or one or more Affiliates of the Person. 
  
 “Tangible Net Worth” is, on any date, the consolidated total
assets of Xenogen and its Subsidiaries (including XBC) minus, (i) any amounts attributable to (a) goodwill, (b) intangible items such as unamortized debt discount and expense, Patents, trade and service marks and names, Copyrights and
research and development expenses except prepaid expenses, and (c) reserves not already deducted from assets, and (ii) Total Liabilities. 
  
 “Threshold Event” is a date on which Xenogen’s Modified Quick Ratio has fallen below 2.00 to 1.00. 
  
 “Total Liabilities” is on any day, obligations that
should, under GAAP, be classified as liabilities on Xenogen’s consolidated balance sheet, including all Indebtedness, and current portion Subordinated Debt allowed to be paid, but excluding all other Subordinated Debt. 
  
 “Trademarks” are trademark and servicemark rights,
registered or not, applications to register and registrations and like protections, and the entire goodwill of the business of Assignor connected with the trademarks. 
  
 *    *    * 
  

 - 28 - 

			
	BORROWERS:
	
	 XENOGEN CORPORATION

		
	 By:
	 	 /s/ William A. Albright

	 Title:
	 	Senior Vice President and Chief Financial Officer
	
	 XENOGEN BIOSCIENCES CORPORATION

		
	 By:
	 	 /s/ William A. Albright

	 Title:
	 	Chief Financial Officer
	
	 BANK:

	
	 SILICON VALLEY BANK

		
	 By:
	 	 /s/ Peter Scott

	 Title:
	 	Senior Vice President

  

 - 29 - 

 EXHIBIT A 
  

The Collateral consists of all of Borrowers’ right, title and interest in and to the following: 
  
 All goods and equipment now owned or hereafter acquired, including, without
limitation, all machinery, fixtures, vehicles (including motor vehicles and trailers), and any interest in any of the foregoing, and all attachments, accessories, accessions, replacements, substitutions, additions, and improvements to any of the
foregoing, wherever located; 
  
 All inventory, now owned or
hereafter acquired, including, without limitation, all merchandise, raw materials, parts, supplies, packing and shipping materials, work in process and finished products including such inventory as is held for sale or lease, or to be furnished under
a contract of service or is temporarily out of Borrower’s custody or possession or in transit and including any returns or repossession upon any accounts or other proceeds, including insurance proceeds, resulting from the sale or disposition of
any of the foregoing and any documents of title representing any of the above; 
  
 All contract rights and general intangibles now owned or hereafter acquired, including, without limitation, goodwill, trademarks, servicemarks, trade styles, trade names, patents, patent applications, leases, license
agreements, franchise agreements, blueprints, drawings, purchase orders, customer lists, route lists, infringements, claims, computer programs, computer discs, computer tapes, literature, reports, catalogs, design rights, income tax refunds,
payments of insurance, payment intangibles, and rights to payment of any kind; 
  
 All now existing and hereafter arising accounts (including health-care insurance receivables), contract rights, royalties, license rights and all other forms of obligations owing to Borrowers arising out of the sale
or lease of goods, the licensing of technology or the rendering of services by Borrowers, whether or not earned by performance, and any and all credit insurance, guaranties, and other security therefor, as well as all merchandise returned to or
reclaimed by Borrowers; 
  
 All documents (including negotiable
documents), cash, deposit accounts, securities, securities entitlements, securities accounts, investment property, financial assets, letters of credit, letter of credit rights, money, certificates of deposit, instruments (including promissory notes)
and chattel paper (including tangible and electronic chattel paper) now owned or hereafter acquired and Borrowers’ Books relating to the foregoing; 
  
 All copyright rights, copyright applications, copyright registrations and like protections in each work of authorship and derivative work thereof, whether
published or unpublished, now owned or hereafter acquired; all trade secret rights, including all rights to unpatented inventions, know-how, operating manuals, license rights and agreements and confidential information, now owned or hereafter
acquired; all claims for damages by way of any past, present and future infringement of any of the foregoing; and 
  
 All Borrowers’ Books relating to the foregoing, and the computers and equipment containing said books and records, and any and all claims, rights and
interests in any of the above and all substitutions for, additions and accessions to and proceeds thereof. 
  
 Notwithstanding the foregoing, the Collateral shall not be deemed to include any copyrights, copyright applications, copyright registration and like
protection in each work of authorship and derivative work thereof, 

 whether published or unpublished, now owned or hereafter acquired; any patents, patent applications and like protections
including without limitation improvements, divisions, continuations, renewals, reissues, extensions and continuations-in-part of the same, trademarks, servicemarks and applications therefor, whether registered or not, and the goodwill of the
business of Borrowers connected with and symbolized by such trademarks, any trade secret rights, including any rights to unpatented inventions, know-how, operating manuals, license rights and agreements and confidential information, now owned or
hereafter acquired; or any claims for damage by way of any past, present and future infringement of any of the foregoing (collectively, the “Intellectual Property”), except that the Collateral shall include the proceeds of all the
Intellectual Property that are accounts, (i.e. accounts receivable) of Borrowers, or general intangibles consisting of rights to payment, if a judicial authority (including a U.S. Bankruptcy Court) holds that a security interest in the underlying
Intellectual Property is necessary to have a security interest in such accounts and general intangibles of Borrowers that are proceeds of the Intellectual Property, then the Collateral shall automatically, and effective as of the Closing Date,
include the Intellectual Property to the extent necessary to permit perfection of Bank’s security interest in such accounts and general intangibles of Borrowers that are proceeds of the Intellectual Property. 
  
 Notwithstanding anything contained in this paragraph, the term Collateral shall not include
any property that is subject to a Lien that is otherwise permitted pursuant to paragraph (c) of the definition of “Permitted Liens.” 

 EXHIBIT B 
  
 LOAN PAYMENT/ADVANCE TELEPHONE REQUEST FORM 
  
 DEADLINE FOR SAME DAY PROCESSING IS 12:00 NOON, P.S.T. 
  

					
	TO: CENTRAL CLIENT SERVICE DIVISION	    	DATE:	 	  

	FAX#: (408) 496-2426	    	TIME:	 	  

  

			
	 FROM:
	 	XENOGEN CORPORATION        and        XENOGEN BIOSCIENCES
CORPORATION                                      
                                        
  
	 	 	 CLIENT NAME (BORROWER)

  

			
	 REQUESTED BY:
	 	_____________________________________________________________________________________
	 	 	 AUTHORIZED SIGNER’S NAME

  

	
	AUTHORIZED SIGNATURE:    ______________________________________________________________________________________________
	
	 PHONE
NUMBER:    ___________________________________________________________________________________________

  

			
	FROM ACCOUNT #                    	 	        TO ACCOUNT #                           
                      

  

			
	REQUESTED TRANSACTION TYPE	 	REQUESTED DOLLAR AMOUNT
	PRINCIPAL INCREASE (ADVANCE)	 	$__________________________________________
	PRINCIPAL PAYMENT (ONLY)	 	$__________________________________________
	INTEREST PAYMENT (ONLY)	 	$__________________________________________
	PRINCIPAL AND INTEREST (PAYMENT)	 	$__________________________________________

  
 OTHER INSTRUCTIONS:
____________________________________________________________________________________ 
  
 ________________________________________________________________________________________________________ 
  
 All Borrowers’ representations and warranties in the Loan and Security Agreement are true, correct and complete in all material respects on the date of the telephone
request for and Advance confirmed by this Borrowing Certificate; but those representations and warranties expressly referring to another date shall be true, correct and complete in all material respects as of that date. 
  
 BANK USE ONLY 
  
 TELEPHONE REQUEST: 
  
 The following person is authorized to request the loan payment transfer/loan advance on the advance designated account and is known to me. 
  

					
	_______________________________________________________________________________________________________________________
	 Authorized Requester
	 	Phone #	 	 
	  
 _______________________________________________________________________________________________________________________

	 Received By (Bank)
	 	Phone #	 	 
	  
 _______________________________________________________________________________________________________________________

	 Authorized Signature (Bank)
	 	 	 	 

  
  

 EXHIBIT C 
 COMPLIANCE CERTIFICATE 
  

			
	TO:	    	SILICON VALLEY BANK
		
	FROM:	    	XENOGEN CORPORATION
	 	    	860 Atlantic Avenue
	 	    	Alameda, California 94501

  
 The undersigned
authorized officer of XENOGEN CORPORATION (“Borrower”) certifies that under the terms and conditions of the Loan and Security Agreement between Borrower and Bank (the “Agreement”), (i) Borrower is in complete compliance for the
period ending                      with all required covenants except as noted below and (ii) all representations and warranties in the
Agreement are true and correct in all material respects on this date. In addition, the undersigned authorized officer of Borrower certifies that Borrower and each Subsidiary (i) has timely filed all required tax returns and paid, or made adequate
provision to pay, all material taxes, except those being contested in good faith with adequate reserves under GAAP and (ii) does not have any legal actions pending or threatened against Borrower or any Subsidiary which Borrower has not previously
notified in writing to Bank. Attached are the required documents supporting the certification. The Officer certifies that these are prepared in accordance with Generally Accepted Accounting Principles (GAAP) consistently applied from one period to
the next except as explained in an accompanying letter or footnotes. The Officer acknowledges that no borrowings may be requested at any time or date of determination that Borrower is not in compliance with any of the terms of the Agreement, and
that compliance is determined not just at the date this certificate is delivered. 
  
 Please indicate compliance status by circling Yes/No under “Complies” column. 
  

							
	 Reporting Covenant

	  	 Required

	  	 Complies

	Monthly financial statements + CC	  	Monthly within 30 days	  	Yes	  	No
				
	Annual (Audited)	  	FYE within 120 days	  	Yes	  	No
				
	A/R, A/P Agings, Deferred Revenue Schedule	  	Monthly within 30 days after last day of month	  	Yes	  	No
				
	Financial Projections	  	Initial and FYE within 45 days	  	Yes	  	No
				
	A/R Audit	  	Annual	  	Yes	  	No

  

									
	 Threshold Event

	  	 Minimum

	 	Actual

	  	Trigger

	 Modified Quick Ratio
	  	2.00:1.00	 	        :1.00	  	Yes	  	No
				
	 Covenants

	  	 Minimum

	 	Actual

	  	Trigger

	 Remaining Months
	  	 	 	 	  	 	  	 
	 Liquidity Ratio
	  	6.00:1.00*	 	        :1.00	  	Yes	  	No
	
 *  4.00:1.00 until October 31, 2005

  
 Borrower only has deposit accounts
located at the following institutions:                                 .

  
 Comments Regarding Exceptions: See Attached. 

	
	Sincerely,
	
	XENOGEN CORPORATION
	
	  

	SIGNATURE
	
	  

	TITLE
	
	  

	DATE

 EXHIBIT D 
  

LOAN AND SECURITY AGREEMENT 
 (ASSET BASED FACILITY) 
  
 Silicon Valley Bank

  
 Loan and Security Agreement 
  
 (Asset Based Facility) 
  

			
	 Borrowers:
  
 XENOGEN CORPORATION
 a Delaware corporation
	 	 Address:
  
 860 Atlantic Avenue
 Alameda, California
94501

		
	 XENOGEN BIOSCIENCES CORPORATION
 an Ohio
corporation
	 	 5 Cedar Brook Drive
 Cranbury, New Jersey
08512

  
 Date:    August
2, 2005 
  
 THIS AMENDED AND RESTATED LOAN AND SECURITY AGREEMENT is
entered into on the above date among SILICON VALLEY BANK (“Silicon”), whose address is 3003 Tasman Drive, Santa Clara, California 95054, Xenogen Corporation (the “Parent”), whose chief executive office is located at
the above address (“Parent’s Address”) and its wholly owned subsidiary, Xenogen Biosciences Corporation (“XBC”), whose chief executive office is located at the above address (“XBC’s
Address”) (Parent and XBC are individually each a “Borrower”, and separately and collectively, the “Borrowers”). The Schedule to this Agreement (the “Schedule”) shall for all purposes be
deemed to be a part of this Agreement, and the same is an integral part of this Agreement. (Definitions of certain terms used in this Agreement are set forth in Section 8 below.) This Agreement shall only become effective upon the occurrence of a
Threshold Event in accordance with Section 9.19. 
  
 1. LOANS.

  
 1.1 Loans.
Silicon will make loans to Borrowers (the “Loans”) up to the amounts (the “Credit Limit”) shown on the Schedule, provided no Default or Event of Default has occurred and is continuing, and subject to deduction of
Reserves for accrued interest and such other Reserves as Silicon deems proper from time to time in its good faith business judgment. 
  

 - 3 - 

 1.2 Interest. All Loans shall bear interest at the rate shown on the
Schedule, except where expressly set forth to the contrary in this Agreement. Interest shall be payable monthly, on the last day of the month. Interest may, in Silicon’s discretion, be charged to Borrower’s loan account, and the same shall
thereafter bear interest at the same rate as the other Loans. Silicon may, in its discretion, charge interest to Borrowers’ Deposit Accounts maintained with Silicon. 
  
 1.3 Overadvances. If at any time or for any reason the total of all outstanding Loans
and all other monetary Obligations exceeds the Credit Limit (an “Overadvance”), Borrowers shall immediately pay the amount of the excess to Silicon, without notice or demand. Without limiting Borrowers’ obligations to repay to
Silicon the amount of any Overadvance, Borrowers agree to pay Silicon interest on the outstanding amount of any Overadvance, on demand, at the Default Rate. 
  
 1.4 Fees. Borrowers shall pay Silicon the fees shown on the Schedule, which are in addition to all interest and other
sums payable to Silicon and are not refundable. 
  
 1.5 Loan Requests. To obtain a Loan, Borrowers shall make a request to Silicon by facsimile or telephone. Loan requests received after 12:00 Noon will not be considered by Silicon until the next Business Day. Silicon
may rely on any telephone request for a Loan given by a person whom Silicon believes is a Responsible Officer of either or both Borrowers, and Borrowers will indemnify Silicon for any loss Silicon suffers as a result of that reliance. Each request
for a Loan shall be in a minimum amount of $100,000. 
  
 1.6 Intentionally Omitted. 
  
 2. SECURITY INTEREST.

  
 (a) To secure the payment and performance of all of the
Obligations when due, Borrowers hereby grant to Silicon a security interest in all of the following (collectively, the “Collateral”): all right, title and interest of Borrowers in and to all of the following, whether now owned or
hereafter arising or acquired and wherever located: all Accounts; all Inventory; all Equipment; all Deposit Accounts; all General Intangibles; all Investment Property (excluding 35% of the equity interests of Subsidiaries formed in jurisdictions
outside of the United States); all Other Property; and any and all claims, rights and interests in any of the above, and all guaranties and security for any of the above, and all substitutions and replacements for, additions, accessions,
attachments, accessories, and improvements to, and proceeds (including proceeds of any insurance policies, proceeds of proceeds and claims against third parties) of, any and all of the above, and all Borrowers’ books relating to any and all of
the above. 
  
 (b) Notwithstanding the foregoing, the Collateral
shall not be deemed to include any copyrights, copyright applications, copyright registration and like protection in each work of authorship and derivative work thereof, whether published or unpublished, now owned or hereafter acquired; any patents,
patent applications and like protections including without limitation improvements, divisions, continuations, renewals, reissues, extensions and 
  

 - 4 - 

 
continuations-in-part of the same, trademarks, servicemarks and applications therefor, whether registered or not, and the goodwill of the business of either
Borrower connected with and symbolized by such trademarks, any trade secret rights, including any rights to unpatented inventions, know-how, operating manuals, license rights and agreements and confidential information, now owned or hereafter
acquired; or any claims for damage by way of any past, present and future infringement of any of the foregoing (collectively, the “Intellectual Property”), except that the Collateral shall include the proceeds of all the
Intellectual Property that are accounts, (i.e. accounts receivable) of either Borrower, or general intangibles consisting of rights to payment, if a judicial authority (including a U.S. Bankruptcy Court) holds that a security interest in the
underlying Intellectual Property is necessary to have a security interest in such accounts and general intangibles of Borrower that are proceeds of the Intellectual Property, then the Collateral shall automatically, and effective as of the Closing
Date, include the Intellectual Property to the extent necessary to permit perfection of Silicon’s security interest in such accounts and general intangibles of Borrowers that are proceeds of the Intellectual Property. Notwithstanding anything
contained in this paragraph, the term Collateral shall not include any property that is subject to a Lien is otherwise permitted pursuant to paragraph (c) of the definition of “Permitted Liens.” 
  
 (c) Notwithstanding anything contained in this Section 2, the term Collateral
shall not include any property that is subject to a lien that is otherwise permitted pursuant to subsection (c) of the definition of “Permitted Liens.” 
  
 3. REPRESENTATIONS, WARRANTIES AND COVENANTS OF BORROWER. In order to induce Silicon to enter into this Agreement and to make Loans,
and except to the extent set forth in the Schedule to the Original Agreement (as defined in Section 9.19) or the Representations, Borrowers jointly and severally, represent and warrant to Silicon as follows, and Borrowers jointly and severally
covenant that Borrowers will at all times comply with all of the following covenants, throughout the term of this Agreement and until all Obligations have been paid and performed in full: 
  
 3.1 Corporate Existence and Authority.
Each Borrower is and will continue to be, duly organized, validly existing and in good standing under the laws of the jurisdiction of its incorporation. Each Borrower is and will continue to be qualified and licensed to do business in all
jurisdictions in which any failure to do so would result in a Material Adverse Change. The execution, delivery and performance by each Borrower of this Agreement, and all other documents contemplated hereby (i) have been duly and validly authorized,
(ii) are enforceable against such Borrower in accordance with their terms (except as enforcement may be limited by equitable principles and by bankruptcy, insolvency, reorganization, moratorium or similar laws relating to creditors’ rights
generally), and (iii) do not violate either Borrower’s articles or certificate of incorporation, or such Borrower’s bylaws, or any law or any material agreement or instrument which is binding upon that Borrower or its property, and (iv) do
not constitute grounds for acceleration of any material indebtedness or obligation under any agreement or instrument which is binding upon either Borrower or its property. 
  

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 3.2 Name; Trade Names and Styles. The name of each Borrower set
forth in the heading to this Agreement, or such other name of which such Borrower has notified Silicon in accordance with this Section 3.2, is its correct name. Listed in the Representations are all prior names of each Borrower and all of
such Borrower’s present and prior trade names. Each Borrower shall give Silicon 30 days’ prior written notice before changing its name or doing business under any other name other than Xenogen. Each Borrower has complied, and will in the
future comply, in all material respects, with all laws relating to the conduct of business under a fictitious business name, except where the failure to so comply would not reasonably be expected to result in a Material Adverse Change. 

 
 3.3 Place of Business; Location of
Collateral. The address set forth in the heading to this Agreement (or such other address of which each Borrower has given notice pursuant to this Section 3.3) is the applicable Borrower’s chief executive office. In addition, each
Borrower has places of business and Collateral is located only at the locations set forth in the Representations (or such other address of which either Borrower has given notice pursuant to this Section 3.3). Borrowers will give Silicon at least 30
days prior written notice before opening any additional place of business, changing either Borrower’s chief executive office, or moving any of the Collateral to a location other than a Borrower’s Address or one of the locations set forth
in the Representations (or such other address of which Borrowers have given notice pursuant to this Section 3.3), except that Borrowers may maintain sales offices in the ordinary course of business at which not more than a total of $100,000 fair
market value of Equipment is located. 
  
 3.4
Title to Collateral; Perfection; Permitted Liens. 
  
 (a) Borrowers are now, and will at all times in the future be, the sole owner of all the Collateral, except for items of Equipment which are leased to Borrowers. The Collateral now is and will remain free and clear of any and all liens,
charges, security interests, encumbrances and adverse claims, except for Permitted Liens. Silicon now has, and will continue to have, a first-priority perfected and enforceable security interest in all of the Collateral, subject only to the
Permitted Liens, and Borrowers will at all times defend Silicon and the Collateral against all claims of others. 
  
 (b) Borrowers have set forth in the Representations all of Borrowers’ Deposit Accounts, and each Borrower will give Silicon five Business Days
advance written notice before establishing any new Deposit Accounts with a bank other than Silicon and will cause the institution where any such new Deposit Account is maintained to execute and deliver to Silicon a control agreement in form
sufficient to perfect Silicon’s security interest in the Deposit Account and otherwise satisfactory to Silicon in its good faith business judgment. Nothing herein limits any requirements which may be set forth in the Schedule as to where
Deposit Accounts will be maintained. 
  
 (c) In the event that
either Borrower shall at any time after the date hereof have any commercial tort claims against others, which it is asserting and in which the potential 
  

 - 6 - 

 recovery exceeds $100,000, such Borrower shall promptly notify Silicon thereof in writing and provide Silicon with such
information regarding the same as Silicon shall request (unless providing such information would waive the Borrower’s attorney-client privilege). Such notification to Silicon shall constitute a grant of a security interest in the commercial
tort claim and all proceeds thereof to Silicon, and Borrowers shall execute and deliver all such documents and take all such actions as Silicon shall request in connection therewith. 
  
 (d) None of the Collateral now is or will be affixed to any real property in such a manner, or with such intent, as to
become a fixture. Neither Borrower is, nor will it become a lessee under any real property lease pursuant to which the lessor may obtain any rights in any of the Collateral and no such lease now prohibits, restrains, impairs or will prohibit,
restrain or impair either Borrower’s right to remove any Collateral from the leased premises. Whenever any Collateral is located upon premises in which any third party has an interest, Borrowers shall, whenever requested by Silicon, use their
commercially reasonable efforts to cause such third party to execute and deliver to Silicon, in form acceptable to Silicon, such waivers and subordinations as Silicon shall specify in its good faith business judgment. Each Borrower will keep in full
force and effect, and will comply with all material terms of, any lease of real property where any of the Collateral now or in the future may be located. 
  
 3.5 Maintenance of Collateral. Borrowers will maintain the Collateral in good working condition (ordinary wear and
tear excepted), and Borrowers will not use the Collateral for any unlawful purpose. Borrowers will promptly advise Silicon in writing of any material loss or damage to the Collateral. 
  
 3.6 Books and Records. Each Borrower has maintained and will maintain at Parent’s
Address complete and accurate books and records sufficient to prepare financial statements in accordance with GAAP. 
  
 3.7 Financial Condition, Statements and Reports. Subject to the absence of footnotes and year-end adjustments in the
case of interim financial statements, all financial statements now or in the future delivered to Silicon have been, and will be, prepared in conformity with GAAP and now and in the future will fairly present in all material respects the results of
operations and financial condition of Parent and its consolidated Subsidiaries (including XBC), in accordance with GAAP, at the times and for the periods therein stated. Between the last date covered by any such statement provided to Silicon and the
date hereof, there has been no Material Adverse Change. 
  
 3.8 Tax Returns and Payments; Pension Contributions. Parent has timely filed, and will timely file, all required tax returns except where failure to file would not reasonably be expected to cause
a Material Adverse Change and reports, and Parent has timely paid, and will timely pay, all foreign, federal, state and local taxes, assessments, deposits and contributions now or in the future owed by Parent on a consolidated basis, except where
such unpaid taxes, assessment, deposits and contributions do not exceed $100,000 in the aggregate and either: (y) cannot result in the imposition of a lien over such Borrower’s assets or (z) cannot result in a Material Adverse Change.
Notwithstanding the foregoing, either Borrower may, however, defer payment of any 
  

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 contested taxes, provided that such Borrower (i) in good faith contests such Borrower’s obligation
to pay the taxes by appropriate proceedings promptly and diligently instituted and conducted, (ii) notifies Silicon in writing of the commencement of, and any material development in, the proceedings, and (iii) posts bonds or takes any other steps
required to keep the contested taxes from becoming a lien upon any of the Collateral. Neither Borrower is aware of any claims or adjustments proposed for any of such Borrower’s prior tax years which could result in additional taxes becoming due
and payable by such Borrower in an amount that could reasonably be expected to cause a Material Adverse Change. Each Borrower has paid, and shall continue to pay all amounts necessary to fund all present and future pension, profit sharing and
deferred compensation plans in accordance with their terms, and each Borrower has not and will not withdraw from participation in, permit partial or complete termination of, or permit the occurrence of any other event with respect to, any such plan
which could reasonably be expected to result in any liability of such Borrower in an amount that could reasonably be expected to cause a Material Adverse Change, including any liability to the Pension Benefit Guaranty Corporation or its successors
or any other governmental agency. 
  
 3.9
Compliance with Law. Each Borrower has, to the best of its knowledge, complied, and will comply, in all material respects, with all provisions of all foreign, federal, state and local laws and regulations applicable to such
Borrower, including, but not limited to, those relating to such Borrower’s ownership of real or personal property, the conduct and licensing of Borrower’s business, and all environmental matters, except where failure to do so could not
reasonably be expected to cause a Material Adverse Change. 
  
 3.10 Litigation. There is no claim, suit, litigation, proceeding or investigation pending or (to Borrower’s knowledge) threatened against either Borrower in any court or before any
governmental agency which could reasonably be expected to result, either separately or in the aggregate, in any Material Adverse Change. Borrowers will promptly inform Silicon in writing of any claim, proceeding, litigation or investigation in the
future threatened or instituted against Borrowers involving any single claim of $250,000 or more, or involving $750,000 or more in the aggregate. 
  
 3.11 Use of Proceeds. All proceeds of all Loans shall be used solely for lawful business purposes. Borrowers are not
purchasing or carrying any “margin stock” (as defined in Regulation U of the Board of Governors of the Federal Reserve System) and no part of the proceeds of any Loan will be used to purchase or carry any “margin stock” or to
extend credit to others for the purpose of purchasing or carrying any “margin stock.” 
  
 4. ACCOUNTS. 
  
 4.1 Representations Relating to Accounts. Borrowers jointly and severally, represent and warrant to Silicon as follows: Each Account with respect to which Loans are requested by Borrowers shall, on the date each Loan is
requested and made, (i) represent an undisputed bona fide existing unconditional obligation of the Account 
  

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 Debtor created by the sale, delivery, and acceptance of goods or the rendition of services, or the
licensing of Intellectual Property, in the ordinary course of each Borrower’s business, and (ii) meet the Minimum Eligibility Requirements set forth in Section 8 below. 
  
 4.2 Representations Relating to Documents and Legal Compliance. Borrowers, jointly and
severally, represent and warrant to Silicon as follows: All statements made and all unpaid balances appearing in all invoices, instruments and other documents evidencing the Accounts are and shall be true and correct and all such invoices,
instruments and other documents and all of Borrowers’ books and records are and shall be genuine and in all respects what they purport to be. All sales and other transactions underlying or giving rise to each Account shall comply in all
material respects with all applicable laws and governmental rules and regulations. To the best of each Borrower’s knowledge, all signatures and endorsements on all documents, instruments, and agreements relating to all Accounts are and shall be
genuine, and all such documents, instruments and agreements are and shall be legally enforceable in accordance with their terms except to the extent that the enforceability thereof may be limited by applicable bankruptcy, insolvency, moratorium and
other similar laws affecting creditors’ rights generally and by equitable principles regardless of whether enforcement is sought in equity or at law. 
  
 4.3 Schedules and Documents relating to Accounts. Borrowers shall deliver to Silicon transaction reports and
schedules of collections, as provided in the Schedule, on Silicon’s standard forms; provided, however, that Borrower’s failure to execute and deliver the same shall not affect or limit Silicon’s security interest and other rights in
all of Borrowers’ Accounts, nor shall Silicon’s failure to advance or lend against a specific Account affect or limit Silicon’s security interest and other rights therein. If requested by Silicon, Borrowers shall furnish Silicon with
copies (or, at Silicon’s request, originals) of all contracts, orders, invoices, and other similar documents, and all shipping instructions, delivery receipts, bills of lading, and other evidence of delivery, for any goods the sale or
disposition of which gave rise to such Accounts, and each Borrower warrants the genuineness of all of the foregoing. Borrowers shall also furnish to Silicon an aged accounts receivable trial balance as provided in the Schedule. In addition,
Borrowers shall deliver to Silicon, on its request, the originals of all instruments, chattel paper, security agreements, guarantees and other documents and property evidencing or securing any Accounts, in the same form as received, with all
necessary indorsements, and copies of all credit memos. 
  
 4.4 Collection of Accounts. Each Borrower shall have the right to collect all Accounts owing to such Borrower, unless and until a Default or an Event of Default has occurred and is continuing.
Whether or not an Event of Default has occurred and is continuing, each Borrower shall hold all payments on, and proceeds of, Accounts in trust for Silicon. Borrowers shall immediately notify and direct all of the such Borrower’s Account
Debtor’s to make all payment’s for the Accounts to a lockbox account established with Silicon (“Lockbox”) or to wire transfer payments to a cash collateral account that Silicon controls. It will be considered an immediate
Event of Default if the Lockbox is not set-up and operational within 30 days of the effective date of this Agreement. 
  

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 4.5 Remittance of Proceeds. All proceeds arising from the
disposition of any Collateral shall be delivered, in kind, by Borrowers to Silicon in the original form in which received by either Borrower not later than the following Business Day after receipt by such Borrower, to be applied to the Obligations
in such order as Silicon shall determine; provided that, if no Default or Event of Default has occurred and is continuing, Borrowers shall not be obligated to remit to Silicon the proceeds of the sale of worn out or obsolete Equipment disposed of by
Borrowers in good faith in an arm’s length transaction for an aggregate purchase price of $25,000 or less (for all such transactions in any fiscal year). Each Borrower agrees that it will not commingle proceeds of Collateral with any of such
Borrower’s other funds or property, but will hold such proceeds separate and apart from such other funds and property and in an express trust for Silicon. Nothing in this Section limits the restrictions on disposition of Collateral set forth
elsewhere in this Agreement. 
  
 4.6
Disputes. Borrowers shall notify Silicon promptly of all disputes or claims relating to Accounts. Neither Borrower shall forgive (completely or partially), compromise or settle any Account for less than payment in full, or agree to
do any of the foregoing, except that Borrowers may do so, provided that: (i) Borrowers do so in good faith, in a commercially reasonable manner, in the ordinary course of business, and in arm’s length transactions, which are reported to Silicon
on the regular reports provided to Silicon; (ii) no Default or Event of Default has occurred and is continuing; and (iii) taking into account all such discounts, settlements and forgiveness, the total outstanding Loans will not exceed the Credit
Limit. 
  
 4.7 Returns.
Provided no Event of Default has occurred and is continuing, if any Account Debtor returns any Inventory to either Borrower, such Borrower shall promptly determine the reason for such return and promptly issue a credit memorandum to the Account
Debtor in the appropriate amount. In the event any attempted return occurs after the occurrence and during the continuance of any Event of Default, Borrowers shall hold the returned Inventory in trust for Silicon, and immediately notify Silicon of
the return of the Inventory. 
  
 4.8
Verification. Silicon may, from time to time, verify directly with the respective Account Debtors the validity, amount and other matters relating to the Accounts, by means of mail, telephone or otherwise, either in the name of
Borrower or Silicon or such other name as Silicon may choose. 
  
 4.9 No Liability. Silicon shall not be responsible or liable for any shortage or discrepancy in, damage to, or loss or destruction of, any goods, the sale or other disposition of which gives rise
to an Account, or for any error, act, omission, or delay of any kind occurring in the settlement, failure to settle, collection or failure to collect any Account, or for settling any Account in good faith for less than the full amount thereof, nor
shall Silicon be deemed to be responsible for any of Borrowers’ obligations under any contract or agreement giving rise to an Account. Nothing herein shall, however, relieve Silicon from liability for its own gross negligence or willful
misconduct. 
  

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 5. ADDITIONAL DUTIES OF BORROWERS. 
  
 5.1 Financial and Other Covenants. Borrowers shall at all times comply with the
financial and other covenants set forth in the Schedule. 
  
 5.2 Insurance. Each Borrower shall, at all times insure all of the tangible personal property Collateral and carry such other business insurance, with insurers reasonably acceptable to Silicon, in
such form and amounts as Silicon may reasonably require and that are customary and in accordance with standard practices for each Borrower’s industry and locations, and each Borrower shall provide evidence of such insurance to Silicon. All such
casualty insurance policies shall name Silicon as an additional loss payee, and shall contain a lenders loss payee endorsement in form reasonably acceptable to Silicon. Upon receipt of the proceeds of any such insurance, Silicon shall apply such
proceeds in reduction of the Obligations as Silicon shall determine in its good faith business judgment, except that, provided no Default or Event of Default has occurred and is continuing, Silicon shall release to the applicable Borrower insurance
proceeds which shall be utilized by such Borrower for the replacement or repair of the damaged or destroyed property with respect to which the insurance proceeds were paid. Silicon may require reasonable assurance that the insurance proceeds so
released will be so used. If either Borrower fails to provide or pay for any insurance, Silicon may, but is not obligated to, obtain the same at Borrowers’ expense. Borrowers shall promptly deliver to Silicon copies of all material reports made
to insurance companies. 
  
 5.3
Reports. Borrowers, at their expense, shall provide Silicon with the written reports set forth in the Schedule, and such other written reports with respect to each Borrower (including budgets, sales projections, operating plans and
other financial documentation), as Silicon shall from time to time reasonably request in its good faith business judgment. 
  
 5.4 Access to Collateral, Books and Records. At reasonable times, and on one Business Day’s notice, Silicon, or
its agents, shall have the right to inspect the Collateral, and the right to audit and copy each Borrower’s books and records. Silicon shall take reasonable steps to keep confidential all information obtained in any such inspection or audit,
but Silicon shall have the right to disclose any such information to its auditors, regulatory agencies, and attorneys, and pursuant to any subpoena or other legal process. The foregoing inspections and audits shall be at Borrowers’ expense and
the charge therefor shall be $750 per person per day, plus reasonable out-of-pocket expenses. In the event a Borrower and Silicon schedule an audit more than 10 days in advance, and either Borrower seeks to reschedules the audit with less than 10
days written notice to Silicon, then (without limiting any of Silicon’s rights or remedies), such Borrower shall pay Silicon a cancellation fee of $1,000 plus any out-of-pocket expenses incurred by Silicon, to compensate Silicon for the
anticipated costs and 
  

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 expenses of the cancellation. Any inspections of Collateral under this Section 5.4 shall be limited to
three (3) per year unless (i) an Event of Default has occurred and is continuing or (ii) in Silicon’s reasonable business judgment conditions otherwise warrant such inspection. 
  
 5.5 Negative Covenants. Neither Borrower shall, without Silicon’s prior written
consent do any of the following: 
  
 (i) merge or consolidate, or
permit any of its Subsidiaries to merge or consolidate, with another Person, or acquire, or permit any of its Subsidiaries to acquire, all or substantially all of the assets or capital stock of any Person, except that (A) any Subsidiary of Parent
may merge into Parent or XBC and (B) a Borrower may acquire another Person if: (v) the aggregate consideration paid for all such transactions do not in the aggregate exceed $2,000,000 in any fiscal year (provided however, that Borrowers may make a
one-time acquisition valued at not more than $7,000,000 (exclusive of the $2,000,000 amount) where the consideration is not cash and Bank has reviewed, and in its sole discretion, consented to the transaction), (w) no Event of Default has occurred
and is continuing or would result from such action during the term of this Agreement, (x) such Borrower is the surviving entity after any such acquisition (to the extent a Borrower was a party thereto), (y) any single transaction does not result in
a material reduction of either Borrower’s cash and cash equivalents or a material increase in Parent’s consolidated monthly cash burn, and (z) such transaction would not result in a decrease of more than 25% of Parent’s Tangible Net
Worth; 
  
 (ii) convey, sell, lease, transfer or otherwise dispose
of (collectively “Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of its business or property, other than Transfers (A) of Inventory in the ordinary course of business (including Transfers of the IVIS
systems); (B) of non-exclusive licenses and similar arrangements for the use of the property of either Borrower or its Subsidiaries in the ordinary course of business; (C) of exclusive licenses of Intellectual Property entered into the ordinary
course of business and approved in good faith by such Borrower’s Board of Directors, so long as: (x) such licenses are limited to specific products or processes or a specific geographic area outside of the United States or Canada; (y) the
duration of any such license does not exceed 5 years; and (z) such exclusive license arrangement is not tantamount to a sale of the subject Intellectual Property; (D) of worn out or obsolete Equipment, (E) Transfers permitted by this Section 5.5,
(F) cross-licenses entered into in settlement of litigation or potential litigation; or (G) other Transfers which in the aggregate do not exceed $250,000 in any fiscal year; 
  
 (iii) store any Inventory or other Collateral with any warehouseman or other third party not specified in the
Representations or otherwise consented to in writing by Silicon; 
  
 (iv) sell any Inventory on a sale-or-return, guaranteed sale, consignment, or other contingent basis and report such transactions to Silicon as Eligible Accounts; 
  
 (v) directly or indirectly acquire or own any Person, or make any Investment in any Person, other than Permitted Investments
or as permitted by Section 5.5(i); 
  

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 (vi) create, incur, assume, or be liable for any Indebtedness other than Permitted Indebtedness;

  
 (vii) pay any dividends (other than dividends payable solely
in capital stock of either Borrower or dividends payable by XBC to Parent) or make any distribution or payment with respect to Parent’s capital stock or redeem, retire, or purchase or otherwise acquire, directly or indirectly, any of
Parent’s capital stock except for (i) repurchases of stock from former employees or directors of either Borrower under the terms of applicable repurchase agreements in an aggregate amount not to exceed $150,000 in the aggregate in any fiscal
year, provided that no Event of Default has occurred, is continuing or would exist after giving effect to the repurchases or (ii) the conversion by either Borrower of any of its convertible securities into other securities pursuant to the terms of
such convertible securities or otherwise in exchange therefor, and payments in cash for any fractional shares; 
  
 (viii) engage, directly or indirectly, in any business other than the businesses currently engaged in by Borrower or reasonably related thereto; or

  
 (ix) dissolve or elect to dissolve. 
  
 (x) Transactions permitted by the foregoing provisions of this Section are
only permitted if no Default or Event of Default would occur as a result of such transaction. 
  
 5.6 Litigation Cooperation. Should any third-party suit or proceeding be instituted by or against Silicon with
respect to any Collateral or relating to either Borrower, Borrowers shall, without expense to Silicon, use reasonable efforts to make available Borrowers and their officers, employees and agents and each Borrower’s books and records, to the
extent that Silicon may deem them reasonably necessary in order to prosecute or defend any such suit or proceeding. 
  
 5.7 Further Assurances. Borrowers agree, at their expense, on request by Silicon, to execute all documents and take
all actions, as Silicon, may, in its good faith business judgment, deem necessary or useful in order to perfect and maintain Silicon’s perfected first-priority security interest in the Collateral (subject to Permitted Liens), and in order to
fully consummate the transactions contemplated by this Agreement. 
  
 6.
TERM. 
  
 6.1 Maturity
Date. This Agreement shall continue in effect until the maturity date set forth on the Schedule (the “Maturity Date”), subject to Section 6.3 below. 
  
 6.2 Early Termination. This Agreement may be terminated prior to the Maturity Date as
follows: (i) by Borrowers, effective three Business Days after written notice of termination is given to Silicon; or (ii) by Silicon at any time after the occurrence and during the continuance of an Event of Default, without notice, effective
immediately. 
  

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 6.3 Payment of Obligations. On the Maturity Date or on any earlier
effective date of termination, Borrowers shall pay and perform in full all Obligations, whether evidenced by installment notes or otherwise, and whether or not all or any part of such Obligations are otherwise then due and payable. Notwithstanding
any termination of this Agreement, all of Silicon’s security interests in all of the Collateral and all of the terms and provisions of this Agreement shall continue in full force and effect until all Obligations have been paid and performed in
full; provided that Silicon may, in its sole discretion, refuse to make any further Loans after termination. No termination shall in any way affect or impair any right or remedy of Silicon, nor shall any such termination relieve Borrowers of any
Obligation to Silicon, until all of the Obligations have been paid and performed in full. Upon payment and performance in full of all the Obligations and termination of this Agreement, Silicon shall promptly terminate its financing statements with
respect to the Borrowers and deliver to each Borrower such other documents as may be required to fully terminate Silicon’s security interests. 
  
 7. EVENTS OF DEFAULT AND REMEDIES. 
  
 7.1 Events of Default. The occurrence of any of the following events shall constitute an “Event of Default”
under this Agreement, and Borrowers shall give Silicon immediate written notice thereof: (a) Any warranty, representation, statement, report or certificate made or delivered to Silicon by Borrowers or any of Borrowers’ officers, employees or
agents, now or in the future, shall be untrue or misleading in a material respect when made or deemed to be made; or (b) Borrowers shall fail to pay when due any Loan or any interest thereon or any other monetary Obligation; or (c) the total Loans
and other Obligations outstanding at any time shall exceed the Credit Limit and Borrowers shall not immediately repay the excess as provided in Section 1.3; or (d) Borrowers fail to perform any other nonmonetary Obligation which by its nature cannot
be cured (including those in Section 5.5) or shall fail to permit Silicon to conduct an inspection or audit as specified in Section 5.4 hereof; or (e) Borrowers shall fail to perform any other nonmonetary Obligation, which failure is not
cured within: (y) five Business Days after the date due with respect to the delivery of any financial statements, compliance certificate, or Borrowing Base Certificate and (z) within 10 Business Days of their due date for all other nonmonetary
obligations which by their nature can be cured; or (f) any levy, assessment, attachment, seizure, lien or encumbrance (other than a Permitted Lien) is made on all or any part of the Collateral which is not cured within 10 days after the occurrence
of the same; or (g) any event of default occurs under any Indebtedness in excess of $100,000, which gives the holder of the Indebtedness the right to accelerate the maturity of such Indebtedness and which is not cured within any applicable cure
period or waived in writing by the holder of the Indebtedness; or (h) either Borrower breaches any material contract or obligation, which has resulted or may reasonably be expected to result in a Material Adverse Change; or (i) Dissolution,
termination of existence, insolvency of either Borrower; or the acquiescence of either Borrower in the appointment of a receiver, trustee or custodian, for all or any material part of the property of, assignment for the benefit of creditors by, or
the commencement of any proceeding by either Borrower under any reorganization, bankruptcy, insolvency, arrangement, readjustment of debt, dissolution or liquidation law or statute of any 
  

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 jurisdiction, now or in the future in effect; or (j) the commencement of any proceeding against a
Borrower under any reorganization, bankruptcy, insolvency, arrangement, readjustment of debt, dissolution or liquidation law or statute of any jurisdiction, now or in the future in effect, which is not cured by the dismissal thereof within 45 days
after the date commenced; or (k) Borrowers make any payment on account of any indebtedness or obligation which has been subordinated to the Obligations other than as permitted in the applicable subordination agreement, or if any Person who has
subordinated such indebtedness or obligations terminates or in any way limits his subordination agreement; or (n) there shall be a Change of Control; or (o) Borrowers shall generally not pay their debts as they become due, or Borrowers shall
conceal, remove or transfer any part of its property, with intent to hinder, delay or defraud its creditors, or make or suffer any transfer of any of its property which may be fraudulent under any bankruptcy, fraudulent conveyance or similar law; or
(p) a Material Adverse Change shall occur. Silicon may cease making any Loans hereunder during any of the above cure periods, and thereafter if an Event of Default has occurred and is continuing. 
  
 7.2 Remedies. Upon the occurrence and
during the continuance of any Event of Default, and at any time thereafter, Silicon, at its option, and without notice or demand of any kind (all of which are hereby expressly waived by Borrowers), may do any one or more of the following: (a) Cease
making Loans or otherwise extending credit to Borrowers under this Agreement or any other Loan Document; (b) Accelerate and declare all or any part of the Obligations to be immediately due, payable, and performable, notwithstanding any deferred or
installment payments allowed by any instrument evidencing or relating to any Obligation; (c) Take possession of any or all of the Collateral wherever it may be found, and for that purpose Borrowers hereby authorize Silicon without judicial process
to enter onto any of Borrowers’ premises without interference to search for, take possession of, keep, store, or remove any of the Collateral, and remain on the premises or cause a custodian to remain on the premises in exclusive control
thereof, without charge for so long as Silicon deems it necessary, in its good faith business judgment, in order to complete the enforcement of its rights under this Agreement or any other agreement; provided, however, that should Silicon seek to
take possession of any of the Collateral by court process, each Borrower hereby irrevocably waives: (i) any bond and any surety or security relating thereto required by any statute, court rule or otherwise as an incident to such possession; (ii) any
demand for possession prior to the commencement of any suit or action to recover possession thereof; and (iii) any requirement that Silicon retain possession of, and not dispose of, any such Collateral until after trial or final judgment; (d)
Require Borrowers to assemble any or all of the Collateral and make it available to Silicon at places designated by Silicon which are reasonably convenient to Silicon and Borrowers, and to remove the Collateral to such locations as Silicon may deem
advisable; (e) Complete the processing, manufacturing or repair of any Collateral prior to a disposition thereof and, for such purpose and for the purpose of removal, Silicon shall have the right to use Borrowers’ premises, vehicles, hoists,
lifts, cranes, and other Equipment and all other property without charge; (f) Sell, lease or otherwise dispose of any of the Collateral, in its condition at the time Silicon obtains possession of it or after further manufacturing, 
  

 - 15 - 

 processing or repair, at one or more public and/or private sales, in lots or in bulk, for cash, exchange
or other property, or on credit, and to adjourn any such sale from time to time without notice other than oral announcement at the time scheduled for sale. Silicon shall have the right to conduct such disposition on Borrowers’ premises without
charge, for such time or times as Silicon deems reasonable, or on Silicon’s premises, or elsewhere and the Collateral need not be located at the place of disposition. Silicon may directly or through any affiliated company purchase or lease any
Collateral at any such public disposition, and if permissible under applicable law, at any private disposition. Any sale or other disposition of Collateral shall not relieve Borrowers of any liability Borrower may have if any Collateral is defective
as to title or physical condition or otherwise at the time of sale; (g) Demand payment of, and collect any Accounts and General Intangibles comprising Collateral and, in connection therewith, each Borrower irrevocably authorizes Silicon to endorse
or sign such Borrower’s name on all collections, receipts, instruments and other documents, to take possession of and open mail addressed to Borrowers and remove therefrom payments made with respect to any item of the Collateral or proceeds
thereof, and, in Silicon’s good faith business judgment, to grant extensions of time to pay, compromise claims and settle Accounts and the like for less than face value; (h) Offset against any sums in any of Borrowers’ general, special or
other Deposit Accounts with Silicon against any or all of the Obligations; and (i) Demand and receive possession of any of Borrowers’ federal and state income tax returns and the books and records utilized in the preparation thereof or
referring thereto. All reasonable attorneys’ fees, expenses, costs, liabilities and obligations incurred by Silicon with respect to the foregoing shall be added to and become part of the Obligations, shall be due on demand, and shall bear
interest at a rate equal to the highest interest rate applicable to any of the Obligations. Without limiting any of Silicon’s rights and remedies, from and after the occurrence and during the continuance of any Event of Default, the interest
rate applicable to the Obligations shall be increased by an additional four percent per annum (the “Default Rate”). 
  
 7.3 Standards for Determining Commercial Reasonableness. Borrowers and Silicon agree that a sale or other disposition
(collectively, “sale”) of any Collateral which complies with the following standards will conclusively be deemed to be commercially reasonable: (i) Notice of the sale is given to Borrowers at least ten days prior to the sale, and,
in the case of a public sale, notice of the sale is published at least five days before the sale in a newspaper of general circulation in the county where the sale is to be conducted; (ii) Notice of the sale describes the collateral in general,
nonspecific terms; (iii) The sale is conducted at a place designated by Silicon, with or without the Collateral being present; (iv) The sale commences at any time between 8:00 a.m. and 6:00 p.m; (v) Payment of the purchase price in cash or by
cashier’s check or wire transfer is required; (vi) With respect to any sale of any of the Collateral, Silicon may (but is not obligated to) direct any prospective purchaser to ascertain directly from Borrowers any and all information concerning
the same. Silicon shall be free to employ other methods of noticing and selling the Collateral, in its discretion, if they are commercially reasonable. 
  

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 7.4 Power of Attorney. Upon the occurrence and during the
continuance of any Event of Default, without limiting Silicon’s other rights and remedies, each Borrower grants to Silicon an irrevocable power of attorney coupled with an interest, authorizing and permitting Silicon (acting through any of its
employees, attorneys or agents) at any time, at its option, but without obligation, with or without notice to Borrowers, and at Borrowers’ expense, to do any or all of the following, in either Borrower’s name or otherwise, but Silicon
agrees that if it exercises any right hereunder, it will do so in good faith and in a commercially reasonable manner: (a) Execute on behalf of such Borrower any documents that Silicon may, in its good faith business judgment, deem advisable in order
to perfect and maintain Silicon’s security interest in the Collateral, or in order to exercise a right of either Borrower or Silicon, or in order to fully consummate all the transactions contemplated under this Agreement, and all other Loan
Documents; (b) Execute on behalf of either Borrower, any invoices relating to any Account, any draft against any Account Debtor and any notice to any Account Debtor, any proof of claim in bankruptcy, any Notice of Lien, claim of mechanic’s,
materialman’s or other lien, or assignment or satisfaction of mechanic’s, materialman’s or other lien; (c) Take control in any manner of any cash or noncash items of payment or proceeds of Collateral; endorse the name of either
Borrower upon any instruments, or documents, evidence of payment or Collateral that may come into Silicon’s possession; (d) Endorse all checks and other forms of remittances received by Silicon; (e) Pay, contest or settle any lien, charge,
encumbrance, security interest and adverse claim in or to any of the Collateral, or any judgment based thereon, or otherwise take any action to terminate or discharge the same; (f) Grant extensions of time to pay, compromise claims and settle
Accounts and General Intangibles for less than face value and execute all releases and other documents in connection therewith; (g) Pay any sums required on account of either Borrower’s taxes or to secure the release of any liens therefor, or
both; (h) Settle and adjust, and give releases of, any insurance claim that relates to any of the Collateral and obtain payment therefor; (i) Instruct any third party having custody or control of any books or records belonging to, or relating to,
Borrowers to give Silicon the same rights of access and other rights with respect thereto as Silicon has under this Agreement; and (j) Take any action or pay any sum required of Borrowers pursuant to this Agreement and any other Loan Documents. Any
and all reasonable sums paid and any and all reasonable costs, expenses, liabilities, obligations and attorneys’ fees incurred by Silicon with respect to the foregoing shall be added to and become part of the Obligations, shall be payable on
demand, and shall bear interest at a rate equal to the highest interest rate applicable to any of the Obligations. In no event shall Silicon’s rights under the foregoing power of attorney or any of Silicon’s other rights under this
Agreement be deemed to indicate that Silicon is in control of the business, management or properties of Borrowers. 
  
 7.5 Application of Proceeds. All proceeds realized as the result of any sale of the Collateral shall be applied by
Silicon first to the reasonable costs, expenses, liabilities, obligations and attorneys’ fees incurred by Silicon in the exercise of its rights under this Agreement, second to the interest due upon any of the Obligations, and third to the
principal of the Obligations, in such order as Silicon shall determine in its sole 
  

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 discretion. Any surplus shall be paid to Borrowers or other persons legally entitled thereto; Borrowers
shall remain liable to Silicon for any deficiency. If, Silicon, in its good faith business judgment, directly or indirectly enters into a deferred payment or other credit transaction with any purchaser at any sale of Collateral, Silicon shall have
the option, exercisable at any time, in its good faith business judgment, of either reducing the Obligations by the principal amount of purchase price or deferring the reduction of the Obligations until the actual receipt by Silicon of the cash
therefor. 
  
 7.6 Remedies
Cumulative. In addition to the rights and remedies set forth in this Agreement, Silicon shall have all the other rights and remedies accorded a secured party under the California Uniform Commercial Code and under all other applicable laws,
and under any other instrument or agreement now or in the future entered into between Silicon and either Borrower, and all of such rights and remedies are cumulative and none is exclusive. Exercise or partial exercise by Silicon of one or more of
its rights or remedies shall not be deemed an election, nor bar Silicon from subsequent exercise or partial exercise of any other rights or remedies. The failure or delay of Silicon to exercise any rights or remedies shall not operate as a waiver
thereof, but all rights and remedies shall continue in full force and effect until all of the Obligations have been fully paid and performed. 
  
 8. DEFINITIONS. As used in this Agreement, the following terms have the following meanings: 
  
 “Account Debtor” means the obligor on an Account. 
  
 “Accounts” means all present and future
“accounts” as defined in the California Uniform Commercial Code in effect on the date hereof with such additions to such term as may hereafter be made, and includes without limitation all accounts receivable and other sums owing to
Borrower. 
  
 “Affiliate” means, with
respect to any Person, a relative, 10% shareholder, director, officer, or employee of such Person, or any parent or subsidiary of such Person, or any Person controlling, controlled by or under common control with such Person. 
  
 “Business Day” means a day on which Silicon is open
for business. 
  
 “Change in Control” is a
transaction in which any “person” or “group” (within the meaning of Section 13(d) and 14(d)(2) of the Securities Exchange Act of 1934, as amended (the “Act”)) becomes the “beneficial owner” (as defined in Rule
13d-3 under the Act), directly or indirectly, of greater than 50% of the shares of all classes of stock then outstanding of Xenogen ordinarily entitled to vote in the election of directors. 
  
 “Code” means the Uniform Commercial Code as adopted
and in effect in the State of California from time to time. 
  
 “Collateral” has the meaning set forth in Section 2 above. 
  

 - 18 - 

 “Contingent Obligations” is, for any Person, any direct or indirect liability,
contingent or not, of that Person for (i) any indebtedness, lease, dividend, letter of credit or other obligation of another such as an obligation directly or indirectly guaranteed, endorsed, co-made, discounted or sold with recourse by that Person,
or for which that Person is directly or indirectly liable; (ii) any obligations for undrawn letters of credit for the account of that Person; and (iii) all obligations from any interest rate, currency or commodity swap agreement, interest rate cap
or collar agreement, or other agreement or arrangement designated to protect a Person against fluctuation in interest rates, currency exchange rates or commodity prices; but “Contingent Obligation” does not include endorsements in the
ordinary course of business. The amount of a Contingent Obligation is the stated or determined amount of the primary obligation for which the Contingent Obligation is made or, if not determinable, the maximum reasonably anticipated liability for it
determined by the Person in good faith; but the amount may not exceed the maximum of the obligations under the guarantee or other support arrangement 
  
 “continuing” and “during the continuance of” when used with reference to a Default or Event of Default
means that the Default or Event of Default has occurred and has not been either waived in writing by Silicon or cured within any applicable cure period. 
  
 “Copyrights” are all copyright rights, applications or registrations and like protections in each work or authorship or derivative
work, whether published or not (whether or not it is a trade secret) now or later existing, created, acquired or held. 
  
 “Default” means any event which with notice or passage of time or both, would constitute an Event of Default. 
  
 “Default Rate” has the meaning set forth in Section
7.2 above. 
  
 “Deferred Revenue” is all
amounts received in advance of performance under a contract and not yet recognized as revenue. 
  
 “Deposit Accounts” means all present and future “deposit accounts” as defined in the California Uniform Commercial Code in effect on the date hereof with such additions to such term
as may hereafter be made, and includes without limitation all general and special bank accounts, demand accounts, checking accounts, savings accounts and certificates of deposit. 
  
 “Eligible Accounts” means, as to each Borrower, Accounts and General Intangibles arising in the
ordinary course of such Borrower’s business from the sale of goods or the rendition of services, or the nonexclusive licensing of Intellectual Property, which Silicon, in its good faith business judgment, shall deem eligible for borrowing.
Without limiting the fact that the determination of which Accounts are eligible for borrowing is a matter of Silicon’s good faith business judgment, the following (the “Minimum Eligibility Requirements”) are the minimum
requirements for a Account to be an Eligible Account: (i) the Account must not be outstanding for more than 90 days from its invoice date (the “Eligibility Period”), (ii) the Account must not represent progress billings, or
be due under a fulfillment or requirements contract with the Account Debtor, (iii) the Account must not be subject to any contingencies (including Accounts arising from sales on consignment, guaranteed sale or other terms pursuant to which payment
by 
  

 - 19 - 

 the Account Debtor may be conditional), (iv) the Account must not be owing from an Account Debtor with whom the Borrower
has any dispute (whether or not relating to the particular Account) (but only the amount in dispute shall be excluded), (v) the Account must not be owing from an Affiliate of the Borrower, (vi) the Account must not be owing from an Account Debtor
which is subject to any insolvency or bankruptcy proceeding, or whose financial condition is not acceptable to Silicon, or which, fails or goes out of a material portion of its business, (vii) the Account must not be owing from the United States or
any department, agency or instrumentality thereof (unless there has been compliance, to Silicon’s satisfaction, with the United States Assignment of Claims Act), (viii) the Account must not be owing from an Account Debtor located outside the
United States or Canada (unless preapproved by Silicon in its discretion in writing, or backed by a letter of credit satisfactory to Silicon, or FCIA insured satisfactory to Silicon), (ix) the Account must not be owing from an Account Debtor to whom
the Borrower is or may be liable for goods purchased from such Account Debtor or otherwise (but, in such case, the Account will be deemed not eligible only to the extent of any amounts owed by that Borrower to such Account Debtor), or (x) the
Account must not be owing by an R&D Party but amounts of such Account in excess of any existing R&D Deferred Revenue relating to such R&D Party shall be deemed Eligible Accounts. Accounts owing from one Account Debtor will not be deemed
Eligible Accounts to the extent they exceed 25% of the total Accounts outstanding. In addition, if more than 50% of the Accounts owing from an Account Debtor are outstanding for a period longer than their Eligibility Period (without regard to
unapplied credits) or are otherwise not eligible Accounts, then all Accounts owing from that Account Debtor will be deemed ineligible for borrowing. Silicon may, from time to time, in its good faith business judgment, extend the Eligibility Period
to 120 days for certain Accounts or otherwise revise the Minimum Eligibility Requirements, upon written notice to the Borrower. 
  
 “Equipment” means all present and future “equipment” as defined in the California Uniform Commercial Code in effect on
the date hereof with such additions to such term as may hereafter be made, and includes without limitation all machinery, fixtures, goods, vehicles (including motor vehicles and trailers), and any interest in any of the foregoing. 
  
 “Event of Default” means any of the events set forth
in Section 7.1 of this Agreement. 
  
 “GAAP” means generally accepted accounting principles consistently applied. 
  
 “General Intangibles” means all present and future “general intangibles” as defined in the California Uniform Commercial
Code in effect on the date hereof with such additions to such term as may hereafter be made, and includes without limitation all Intellectual Property, payment intangibles, royalties, contract rights, goodwill, franchise agreements, purchase orders,
customer lists, route lists, telephone numbers, domain names, claims, income tax refunds, security and other deposits, options to purchase or sell real or personal property, rights in all litigation presently or hereafter pending (whether in
contract, tort or otherwise), insurance policies (including without limitation key man, property damage, and business interruption insurance), payments of insurance and rights to payment of any kind. 
  
 “good faith business judgment” means honesty in fact
and good faith (as defined in Section 1201 of the Code) in the exercise of Silicon’s business judgment. 
  

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 “including” means including (but not limited to). 
  
 “Indebtedness” is (a) indebtedness for borrowed money
or the deferred price of property or services, such as reimbursement and other obligations for surety bonds and letters of credit, (b) obligations evidenced by notes, bonds, debentures or similar instruments, (c) capital lease obligations and (d)
Contingent Obligations. 
  
 “Intellectual
Property” is: 
  
 (a) Copyrights, Trademarks, and
Patents including amendments, renewals, extensions, and all licenses or other rights to use and all license fees and royalties from the use; 
  
 (b) Any trade secrets and any intellectual property rights in computer software and computer software products now or later existing, created, acquired or
held; 
  
 (c) All design rights which may be available to either
Borrower now or later created, acquired or held; 
  
 (d) Any
claims for damages (past, present or future) for infringement of any of the rights above, with the right, but not the obligation, to sue and collect damages for use or infringement of the intellectual property rights above; 
  
 All proceeds and products of the foregoing, including all insurance,
indemnity or warranty payments. 
  
 “Inventory” means all present and future “inventory” as defined in the California Uniform Commercial Code in effect on the date hereof with such additions to such term as may hereafter be made, and includes
without limitation all merchandise, raw materials, parts, supplies, packing and shipping materials, work in process and finished products, including without limitation such inventory as is temporarily out of either Borrower’s custody or
possession or in transit and including any returned goods and any documents of title representing any of the above. 
  
 “Investment Property” means all present and future investment property, securities, stocks, bonds, debentures, debt securities,
partnership interests, limited liability company interests, options, security entitlements, securities accounts, commodity contracts, commodity accounts, and all financial assets held in any securities account or otherwise, and all options and
warrants to purchase any of the foregoing, wherever located, and all other securities of every kind, whether certificated or uncertificated. 
  
 “Lien” is a mortgage, lien, deed of trust, charge, pledge, security interest or other encumbrance. 
  
 “Loan Documents” means, collectively, this Agreement,
the Representations, and all other present and future documents, instruments and agreements between Silicon and either Borrower, including, but not limited to those relating to this Agreement, and all amendments and modifications thereto and
replacements therefor. 
  

 - 21 - 

 “Material Adverse Change” means any of the following: (i) a material adverse
change in the business, operations, or financial or other condition of the Parent and its Subsidiaries taken as a whole, or (ii) a material impairment of the prospect of repayment of any portion of the Obligations; or (iii) a material impairment of
the value or priority of Silicon’s security interests in the Collateral. 
  
 “Obligations” means all present and future Loans, advances, debts, liabilities, obligations, guaranties, covenants, duties and indebtedness at any time owing by Borrowers to Silicon, whether
evidenced by this Agreement or any note or other instrument or document, or otherwise, whether arising from an extension of credit, opening of a letter of credit, banker’s acceptance, loan, guaranty, indemnification or otherwise, whether direct
or indirect (including, without limitation, those acquired by assignment and any participation by Silicon in either Borrower’s debts owing to others), absolute or contingent, due or to become due, including, without limitation, all interest,
charges, expenses, fees, attorney’s fees, expert witness fees, audit fees, letter of credit fees, collateral monitoring fees, closing fees, facility fees, termination fees, interest charges and any other sums chargeable to Borrower under this
Agreement or under any other Loan Documents. 
  
 “Other
Property” means the following as defined in the Code in effect on the date hereof with such additions to such term as may hereafter be made, and all rights relating thereto: all present and future “commercial tort claims”
(including without limitation any commercial tort claims identified in the Representations), “documents”, “instruments”, “promissory notes”, “chattel paper”, “letters of credit”,
“letter-of-credit rights”, “fixtures”, “farm products” and “money”; and all other goods and personal property of every kind, tangible and intangible, whether or not governed by the Code. 
  
 “Patents” are patents, patent applications and like
protections, including improvements, divisions, continuations, renewals, reissues, extensions and continuations-in-part of the same. 
  
 “Payment” means all checks, wire transfers and other items of payment received by Silicon (including proceeds of Accounts and
payment of the Obligations in full) for credit to Borrowers’ outstanding Loans or, if the balance of the Loans have been reduced to zero, for credit to its Deposit Accounts. 
  
 “Permitted Indebtedness” is: 
  
 (a) each Borrower’s indebtedness to Silicon under this Agreement or any other Loan Document; 
  
 (b) Indebtedness existing on the Closing Date and shown on the Schedule;

  
 (c) Subordinated Debt; 
  
 (d) Indebtedness to trade creditors incurred in the ordinary course of
business; 
  

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 (e) Indebtedness secured by Permitted Liens; 
  
 (f) Indebtedness of each Borrower to any Subsidiary and Contingent
Obligations of any Subsidiary with respect to obligations of Borrowers (provided that the primary obligations are not prohibited hereby), and Indebtedness of any Subsidiary to any other Subsidiary and Contingent Obligations of any Subsidiary with
respect to obligations of any other Subsidiary (provided that the primary obligations are not prohibited hereby); 
  
 (g) Other Indebtedness not otherwise permitted by Section 5.5 not exceeding One Hundred Fifty Thousand Dollars ($150,000) in the aggregate outstanding at
any time; and 
  
 (h) Extensions, refinancings, modifications,
amendments and restatements of any items of Permitted Indebtedness (a) through (f) above, provided that the principal amount thereof is not increased or the terms thereof are not modified to impose more burdensome terms upon either Borrower or its
Subsidiary, as the case may be. 
  
 “Permitted
Investments” are: 
  
 (a) Investments shown on the
Representations and existing on the date hereof; 
  
 (b)
Marketable direct obligations issued or unconditionally guaranteed by the United States or its agency or any State maturing within 1 year from its acquisition, (ii) commercial paper maturing no more than 1 year after its creation and having the
highest rating from either Standard & Poor’s Corporation or Moody’s Investors Service, Inc., and (iii) Silicon’s certificates of deposit issued maturing no more than 1 year after issue, and (iv) any Investments permitted by
Parent’s investment policy, as amended from time to time, provided that such investment policy (and any such amendment thereto) has been approved by Silicon; 
  
 (c) Investments consisting of the endorsement of negotiable instruments for deposit or collection or similar transactions in
the ordinary course of each Borrower’s business; 
  
 (d)
Investments accepted in connection with Transfers permitted by Section 5.5; 
  
 (e) Investments of Subsidiaries in or to other Subsidiaries or Borrowers and Investments by Borrowers in Subsidiaries not to exceed $250,000 in the aggregate in any fiscal year; 
  
 (f) Investments consisting of (i) travel advances and employee relocation
loans and other employee loans and advances in the ordinary course of business not to exceed $250,000 in any one fiscal year or $300,000 at any one time outstanding, and (ii) loans to employees, officers or directors relating to the purchase of
equity securities of either Borrower or its Subsidiaries pursuant to employee stock purchase plans or agreements approved by such Borrower’s Board of Directors; 
  
 (g) Investments (including debt obligations) received in connection with the bankruptcy or reorganization of customers or
suppliers and in settlement of delinquent obligations of, and other disputes with, customers or suppliers arising in the ordinary course of business; 
  

 - 23 - 

 (h) Investments consisting of notes receivable of, or prepaid royalties and other credit extensions, to
customers and suppliers who are not Affiliates, in the ordinary course of business; provided that this paragraph (h) shall not apply to Investments of either Borrower in any Subsidiary; 
  
 (i) Investments pursuant to investment policy guidelines approved by either Borrower’s Board of Directors and Silicon
set forth Exhibit E to the Original Agreement; and 
  
 (j) Joint
ventures or strategic alliances in the ordinary course of either Borrower’s business consisting of the non-exclusive licensing of technology, the development of technology or the providing of technical support, provided that any cash
investments by Borrowers does not exceed $50,000 in the aggregate in any fiscal year. 
  
 “Permitted Liens” are: 
  
 (a) Liens existing on the Closing Date and shown on the Schedule or arising under this Agreement or other Loan Documents; 
  
 (b) Liens for taxes, fees, assessments or other government charges or levies, either not delinquent or being contested in good faith and for which the
Borrower maintains adequate reserves on its Books, if they have no priority over any of Silicon’s security interests; 
  
 (c) Purchase money Liens (i) on Equipment acquired or held by either Borrower or its Subsidiaries incurred for financing the acquisition of the Equipment,
or (ii) existing on equipment when acquired, if the Lien is confined to the property and improvements and the proceeds of the equipment; 
  
 (d) Licenses or sublicenses granted in the ordinary course of each Borrower’s business and any interest or title of a licensor or under any license
or sublicense; 
  
 (e) Leases or subleases granted in the ordinary
course of each Borrower’s business, including in connection with such Borrower’s leased premises or leased property; 
  
 (f) Liens incurred in the extension, renewal or refinancing of the indebtedness secured by Liens described in (a) through (c), but any extension, renewal
or replacement Lien must be limited to the property encumbered by the existing Lien and the principal amount of the indebtedness may not increase; 
  
 (g) Liens arising from judgments, decrees or attachments in circumstances not constituting an Event of Default under Section 7.1; 
  
 (h) Liens in favor of other financial institutions arising in connection with
either Borrower’s deposit accounts held at such institutions, provided that Silicon has a perfected security interest in the amounts held in such deposit accounts; 
  

 - 24 - 

 (i) carriers’, warehousemen’s, mechanics’, materialmen’s, repairmen’s or other
like Liens arising in the ordinary course of business which are not overdue for a period of more than 30 days or which are being contested in good faith and by appropriate proceedings if adequate reserves with respect thereto are maintained on the
books of the applicable Person; 
  
 (j) Liens to secure payment of
workers’ compensation, employment insurance, old age pensions, social security or other like obligations incurred in the ordinary course of business; 
  
 (k) easements, rights-of-way, restrictions and other similar encumbrances affecting real property which, in the aggregate, are not substantial in amount,
and which do not in any case materially detract from the value of the property subject thereto or materially interfere with the ordinary conduct of the business of the applicable Person; and 
  
 (l) Liens in favor of customs and revenue authorities arising as a matter of
law to secure payment of customs duties in connection with the importation of goods; and 
  
 (m) additional security interests and Liens consented to in writing by Silicon, which consent may be withheld in Silicon’s good faith business judgment. 
  
 Silicon will have the right to require, as a condition to its consent under
subparagraph (m) above, that the holder of the additional security interest or lien sign an intercreditor agreement on Silicon’s then standard form, acknowledge that the security interest is subordinate to the security interest in favor of
Silicon, and agree not to take any action to enforce its subordinate security interest so long as any Obligations remain outstanding, and that Borrowers agree that any uncured default in any obligation secured by the subordinate security interest
shall also constitute an Event of Default under this Agreement. 
  
 “Person” means any individual, sole proprietorship, partnership, joint venture, trust, unincorporated organization, association, corporation, government, or any agency or political division thereof, or any other
entity. 
  
 “Representations” means the
written Representations and Warranties attached as Exhibit C provided by the Borrowers to Silicon upon the Threshold Event (as defined in the Original Agreement). 
  
 “R&D Collaboration” is a transaction whereby an R&D Party provides either Borrower with cash
for the purpose of a research and development collaboration. 
  
 “R&D Deferred Revenue” is cash received by either Borrower from an R&D Party that due to the structure of the applicable R&D Collaboration is reflected as Deferred Revenue in such Borrower’s books.

  
 “R&D Party” is any Person that
enters into an R&D Collaboration with either Borrower. 
  
 “Reserves” means, as of any date of determination, such amounts as Silicon may from time to time establish and revise in its good faith business judgment, reducing the amount of Loans and other financial
accommodations which would otherwise be available to Borrowers 
  

 - 25 - 

 under the lending formula(s) provided in the Schedule: (a) to reflect events, conditions, contingencies or risks which,
as determined by Silicon in its good faith business judgment, do or may adversely affect (i) the Collateral or any other property which is security for the Obligations or its value (including without limitation any increase in delinquencies of
Accounts), (ii) the assets, business or prospects of either Borrower or any Guarantor, or (iii) the security interests and other rights of Silicon in the Collateral (including the enforceability, perfection and priority thereof); or (b) to reflect
Silicon’s good faith belief that any collateral report or financial information furnished by or on behalf of Borrowers or any Guarantor to Silicon is or may have been incomplete, inaccurate or misleading in any material respect; or (c) in
respect of any state of facts which Silicon determines in good faith constitutes an Event of Default or may, with notice or passage of time or both, constitute an Event of Default. 
  
 “Responsible Officer” is, as to each Borrower, each of the Chief Executive Officer, the President,
the Chief Financial Officer, Vice President of Finance and the Controller of that Borrower. 
  
 “Subordinated Debt” is debt incurred by either Borrower subordinated to such Borrower’s indebtedness owed to Silicon and which is reflected in a written agreement in a manner and form
acceptable to Silicon and approved by Silicon in writing. 
  
 “Subsidiary” is for any Person, or any other business entity of which more than 50% of the voting stock or other equity interests is owned or controlled, directly or indirectly, by the Person or one or more
Affiliates of the Person. 
  
 “Tangible Net
Worth” is, on any date, the consolidated total assets of each Parent and its Subsidiaries minus, (i) any amounts attributable to (a) goodwill, (b) intangible items such as unamortized debt discount and expense, Patents, trade and
service marks and names, Copyrights and research and development expenses except prepaid expenses, and (c) reserves not already deducted from assets, and (ii) Total Liabilities. 
  
 “Total Liabilities” is on any day, obligations that should, under GAAP, be classified as liabilities
on Parent’s consolidated balance sheet, including all indebtedness, and current portion Subordinated Debt allowed to be paid, but excluding all other Subordinated Debt. 
  
 “Trademarks” are trademark and servicemark rights, registered or not, applications to register and
registrations and like protections, and the entire goodwill of the business of Assignor connected with the trademarks. 
  
 Other Terms. All accounting terms used in this Agreement, unless otherwise indicated, shall have the meanings given to such terms in
accordance with GAAP, consistently applied. All other terms contained in this Agreement, unless otherwise indicated, shall have the meanings provided by the Code, to the extent such terms are defined therein. 
  

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 9. GENERAL PROVISIONS. 
  

9.1 Interest Computation; Float Charge. In computing interest on the Obligations, all Payments received after
12:00 Noon on any day shall be deemed received on the next Business Day. In addition, Silicon shall be entitled to charge Borrower a “float” charge in an amount equal to three Business Days interest, at the interest rate applicable to the
Loans, on all Payments received by Silicon (except for Payments made by wire transfer to Silicon for which Borrower shall receive credit on the date of receipt). The float charge for each month shall be payable on the last day of the month.

  
 9.2 Application of
Payments. All payments with respect to the Obligations may be applied, and in Silicon’s good faith business judgment reversed and reapplied, to the Obligations, in such order and manner as Silicon shall determine in its good faith
business judgment. 
  
 9.3 Charges
to Accounts. Silicon may, in its discretion, require that Borrowers pay monetary Obligations in cash to Silicon, or charge them to Borrower’s Loan account, in which event they will bear interest at the same rate applicable to the Loans.
Silicon may also, in its discretion, charge any monetary Obligations to either Borrower’s Deposit Accounts maintained with Silicon. 
  
 9.4 Monthly Accountings. Silicon shall provide Borrowers monthly with an account of advances, charges, expenses and
payments made pursuant to this Agreement. Such account shall be deemed correct, accurate and binding on Borrowers and an account stated (except for reverses and reapplications of payments made and corrections of errors discovered by Silicon), unless
Borrowers notify Silicon in writing to the contrary within 60 days after such account is rendered, describing the nature of any alleged errors or omissions. 
  
 9.5 Notices. All notices to be given under this Agreement shall be in writing and shall be given either personally or
by reputable private delivery service or by regular first-class mail, or certified mail return receipt requested, addressed to Silicon or either Borrower at the addresses shown in the heading to this Agreement, or at any other address designated in
writing by one party to the other party. Notices to Silicon shall be directed to the Commercial Finance Division, to the attention of the Division Manager or the Division Credit Manager. All notices shall be deemed to have been given upon delivery
in the case of notices personally delivered, or at the expiration of one Business Day following delivery to the private delivery service, or two Business Days following the deposit thereof in the United States mail, with postage prepaid. 

 
 9.6 Severability. Should any
provision of this Agreement be held by any court of competent jurisdiction to be void or unenforceable, such defect shall not affect the remainder of this Agreement, which shall continue in full force and effect. 
  

 - 27 - 

 9.7 Integration. This Agreement and such other written agreements,
documents and instruments as may be executed in connection herewith (including the Non-Disclosure Agreement, dated as of June 30, 2004) are the final, entire and complete agreement between Borrower and Silicon and supersede all prior and
contemporaneous negotiations and oral representations and agreements, all of which are merged and integrated in this Agreement. There are no oral understandings, representations or agreements between the parties which are not set forth in this
Agreement or in other written agreements signed by the parties in connection herewith. 
  
 9.8 Waivers; Indemnity. 
  
 (a) The failure of Silicon at any time or times to require Borrowers to strictly comply with any of the provisions of this Agreement or any other Loan
Document shall not waive or diminish any right of Silicon later to demand and receive strict compliance therewith. Any waiver of any default shall not waive or affect any other default, whether prior or subsequent, and whether or not similar. None
of the provisions of this Agreement or any other Loan Document shall be deemed to have been waived by any act or knowledge of Silicon or its agents or employees, but only by a specific written waiver signed by an authorized officer of Silicon and
delivered to Borrowers. Each Borrower waives the benefit of all statutes of limitations relating to any of the Obligations or this Agreement or any other Loan Document, and Borrower waives demand, protest, notice of protest and notice of default or
dishonor, notice of payment and nonpayment, release, compromise, settlement, extension or renewal of any commercial paper, instrument, account, General Intangible, document or guaranty at any time held by Silicon on which Borrowers are or may in any
way be liable, and notice of any action taken by Silicon, unless expressly required by this Agreement. Each Borrower, jointly and severally, hereby agrees to indemnify Silicon and its affiliates, subsidiaries, parent, directors, officers, employees,
agents, and attorneys, and to hold them harmless from and against any and all claims, debts, liabilities, demands, obligations, actions, causes of action, penalties, costs and expenses (including reasonable attorneys’ fees), of every kind,
which they may sustain or incur based upon or arising out of any of the Obligations, or any relationship or agreement between Silicon and either Borrower, or any other matter, relating to Borrowers or the Obligations; provided that this indemnity
shall not extend to damages proximately caused by the indemnitee’s own gross negligence or willful misconduct. Notwithstanding any provision in this Agreement to the contrary, the indemnity agreement set forth in this Section shall survive any
termination of this Agreement and shall for all purposes continue in full force and effect. 
  
 (b) Suretyship Waivers. Each Borrower hereby expressly waives (i) diligence, presentment, demand for payment, protest, benefit of any statute of limitations affecting such Borrower’s liability under the
Loan Documents; (ii) discharge due to any disability of any Borrower; (iii) any defenses of any Borrower to obligations under the Loan Documents not arising under the express terms of the Loan Documents or from a material breach thereof by Borrower
which under applicable law has the effect of discharging any Borrower from the Obligations as to which this Agreement is sought to be enforced; (iv) the benefit of any act or omission by Borrower which directly or indirectly results in or aids the
discharge of any Borrower from any of the Obligations by operation of law or otherwise; (v) except as expressly provided herein, all notices whatsoever, including, without limitation, notice of acceptance of the 
  

 - 28 - 

 incurring of the Obligations; (vi) any right it may have to require Borrower to disclose to it any information that
Borrower may now or hereafter acquire concerning the financial condition or any circumstances that bears on the risk of nonpayment by any other Borrower, including, without limitation, the release of such other Borrower from its Obligations
hereunder; and (vii) any requirement that Borrower exhaust any right, power or remedy or proceed against any other Borrower or any other security for, or any guarantor of, or any other party liable for, any of the Obligations, or any portion
thereof. Each Borrower specifically agrees that it shall not be necessary or required, and Borrowers shall not be entitled to require, that Borrower (i) file suit or proceed to assert or obtain a claim for personal judgment against any other
Borrower for all or any part of the Obligations; (ii) make any effort at collection or enforcement of all or any part of the Obligations from any Borrower; (iii) foreclose against or seek to realize upon any security now or hereafter existing for
all or any part of the Obligations; (iv) file suit or proceed to obtain or assert a claim for personal judgment against any Borrower or any guarantor or other party liable for all or any part of the Obligations; (v) exercise or assert any other
right or remedy to which Borrower is or may be entitled in connection with the Obligations or any security or guaranty relating thereto to assert; or (vi) file any claim against assets of one Borrower before or as a condition of enforcing the
liability of any other Borrower under this Agreement or the Notes. Without limiting the generality of the foregoing, each Borrower expressly waives the benefit of California Civil Code Sections 2809, 2810, 2819, 2839, 2845, 2848 (until such time as
the Obligations are satisfied in full), 2849 (until such time as the Obligations are satisfied in full), 2850, 2899 and 1432. WITHOUT LIMITING THE FOREGOING IN
ANY WAY, EACH BORROWER HEREBY IRREVOCABLY WAIVES AND RELEASES: 
  
 (A) Any and all rights it may have at any time (whether
arising directly or indirectly, by operation of law, contract or otherwise) to require the marshaling of any assets of any Borrower, which right of marshaling might otherwise arise from any such payments made or obligations performed; 
  
 (B) Until such time as the obligations have been satisfied
in full, any and all rights that would result in such Borrower being deemed a “creditor” under the bankruptcy code of any other Borrower or any other person, on account of payments made or obligations performed by such Borrower; and

  
 (C) Until such time as the obligations have
been satisfied in full, any claim, right or remedy which it may now have or hereafter acquire against any other Borrower that arises hereunder and/or from the performance by it hereunder including, without limitation, any claim, remedy or right of
subrogation, reimbursement, exoneration, contribution, indemnification or participation in any claim, right or remedy of Bank against any other Borrower or any collateral security which Bank now have or may hereafter acquire, whether or not such
claim, right or remedy arises in equity, under contract, by statute, under common law or otherwise (including without limitation under section 9.9 hereof). 
  
 9.9 No Liability for Ordinary Negligence. Neither Silicon, nor any of its directors, officers, employees, agents,
attorneys or any other Person affiliated with or representing Silicon shall be liable for any claims, demands, losses or damages, of any 
  

 - 29 - 

 kind whatsoever, made, claimed, incurred or suffered by Borrowers or any other party through the ordinary
negligence of Silicon, or any of its directors, officers, employees, agents, attorneys or any other Person affiliated with or representing Silicon, but nothing herein shall relieve Silicon from liability for its own gross negligence or willful
misconduct. 
  
 9.10
Amendment. The terms and provisions of this Agreement may not be waived or amended, except in a writing executed by Borrower and a duly authorized officer of Silicon. 
  
 9.11 Time of Essence. Time is of the essence in the performance by Borrowers of each
and every obligation under this Agreement. 
  
 9.12 Attorneys Fees and Costs. Borrowers shall reimburse Silicon for all reasonable attorneys’ fees and all filing, recording, search, title insurance, appraisal, audit, and other reasonable costs incurred by
Silicon, pursuant to, or in connection with, or relating to this Agreement (whether or not a lawsuit is filed), including, but not limited to, any reasonable attorneys’ fees and costs Silicon incurs in order to do the following: prepare and
negotiate this Agreement and all present and future documents relating to this Agreement; obtain legal advice in connection with this Agreement or Borrowers; enforce, or seek to enforce, any of its rights; prosecute actions against, or defend
actions by, Account Debtors; commence, intervene in, or defend any action or proceeding; initiate any complaint to be relieved of the automatic stay in bankruptcy; file or prosecute any probate claim, bankruptcy claim, third-party claim, or other
claim; subject to any limitations on fees specified elsewhere herein; examine, audit, copy, and inspect any of the Collateral or any of Borrowers’ books and records; protect, obtain possession of, lease, dispose of, or otherwise enforce
Silicon’s security interest in, the Collateral; and otherwise represent Silicon in any litigation relating to Borrower. In satisfying Borrowers’ obligation hereunder to reimburse Silicon for attorneys fees, Borrower may, for convenience,
issue checks directly to Silicon’s attorneys, Buchalter, Nemer, Fields & Younger, but Borrowers acknowledge and agree that Buchalter, Nemer, Fields & Younger is representing only Silicon and not Borrower in connection with this
Agreement. If either Silicon or Borrower files any lawsuit against the other predicated on a breach of this Agreement, the prevailing party in such action shall be entitled to recover its reasonable costs and attorneys’ fees, including (but not
limited to) reasonable attorneys’ fees and costs incurred in the enforcement of, execution upon or defense of any order, decree, award or judgment. All attorneys’ fees and costs to which Silicon may be entitled pursuant to this Paragraph
shall immediately become part of Borrowers’ Obligations, shall be due on demand, and shall bear interest at a rate equal to the highest interest rate applicable to any of the Obligations. 
  
 9.13 Benefit of Agreement. The
provisions of this Agreement shall be binding upon and inure to the benefit of the respective successors, assigns, heirs, beneficiaries and representatives of Borrowers and Silicon; provided, however, that Borrowers may not assign or transfer any of
its rights under this Agreement without the prior written consent of Silicon, and any prohibited assignment shall be void. No consent by Silicon to any assignment shall release Borrowers from its liability for the Obligations. 
  
  

 - 30 - 

 9.14 Intentionally Deleted. 
  
 9.15 Limitation of Actions. Any claim
or cause of action by Borrowers against Silicon, its directors, officers, employees, agents, accountants or attorneys, based upon, arising from, or relating to this Loan Agreement, or any other Loan Document, or any other transaction contemplated
hereby or thereby or relating hereto or thereto, or any other matter, cause or thing whatsoever, occurred, done, omitted or suffered to be done by Silicon, its directors, officers, employees, agents, accountants or attorneys, shall be barred unless
asserted by Borrowers by the commencement of an action or proceeding in a court of competent jurisdiction by the filing of a complaint within one year after the first act, occurrence or omission upon which such claim or cause of action, or any part
thereof, is based, and the service of a summons and complaint on an officer of Silicon, or on any other person authorized to accept service on behalf of Silicon, within thirty (30) days thereafter. Each Borrower agrees that such one-year period is a
reasonable and sufficient time for Borrowers to investigate and act upon any such claim or cause of action. The one-year period provided herein shall not be waived, tolled, or extended except by the written consent of Silicon in its sole discretion.
This provision shall survive any termination of this Loan Agreement or any other Loan Document. 
  
 9.16 Paragraph Headings; Construction. Paragraph headings are only used in this Agreement for convenience. Borrowers
and Silicon acknowledge that the headings may not describe completely the subject matter of the applicable paragraph, and the headings shall not be used in any manner to construe, limit, define or interpret any term or provision of this Agreement.
This Agreement has been fully reviewed and negotiated between the parties and no uncertainty or ambiguity in any term or provision of this Agreement shall be construed strictly against Silicon or Borrowers under any rule of construction or
otherwise. 
  
 9.17 Governing Law;
Jurisdiction; Venue. This Agreement and all acts and transactions hereunder and all rights and obligations of Silicon and Borrowers shall be governed by the laws of the State of California. As a material part of the consideration to Silicon
to enter into this Agreement, each Borrower (i) agrees that all actions and proceedings relating directly or indirectly to this Agreement shall, at Silicon’s option, be litigated in courts located within California, and that the exclusive venue
therefor shall be Santa Clara County; (ii) consents to the jurisdiction and venue of any such court and consents to service of process in any such action or proceeding by personal delivery or any other method permitted by law; and (iii) waives any
and all rights Borrowers may have to object to the jurisdiction of any such court, or to transfer or change the venue of any such action or proceeding. 
  
 9.18 Mutual Waiver of Jury Trial. EACH BORROWER AND SILICON EACH HEREBY WAIVE THE RIGHT TO TRIAL BY JURY IN ANY
ACTION OR PROCEEDING BASED UPON, ARISING OUT OF, OR IN ANY WAY RELATING 
  

 - 31 - 

 TO, THIS AGREEMENT OR ANY OTHER PRESENT OR FUTURE INSTRUMENT OR AGREEMENT BETWEEN SILICON AND BORROWER,
OR ANY CONDUCT, ACTS OR OMISSIONS OF SILICON OR BORROWERS OR ANY OF THEIR DIRECTORS, OFFICERS, EMPLOYEES, AGENTS, ATTORNEYS OR ANY OTHER PERSONS AFFILIATED WITH SILICON OR BORROWERS, IN ALL OF THE FOREGOING CASES, WHETHER SOUNDING IN CONTRACT OR
TORT OR OTHERWISE. 
  
 9.19
Effectiveness; Amended and Restated Agreement. This Agreement shall be effective automatically and without further action on the part of Borrowers and Silicon upon the occurrence of a Threshold Event, as such term is defined in
that certain Amended and Restated Loan and Security Agreement, dated as of even date herewith (as the same may be amended, supplemented, modified, or amended and restated from time to time, the “Original Agreement”). Borrowers and
Silicon hereby agree that, effective upon such Threshold Event, the terms and provisions of the Original Agreement shall be and hereby are amended, restated and superseded in their entirety by the terms and provisions of this Agreement. Nothing
herein contained shall be construed as a substitution or novation of the obligations of Borrowers outstanding under the Original Agreement or instruments securing the same, which obligations shall remain in full force and effect, except to the
extent that the terms thereof are modified hereby or by instruments executed concurrently herewith. Nothing expressed or implied in this Agreement shall be construed as a release or other discharge of any guarantor from any of its obligations or
liabilities under the Original Agreement or any of the security agreements, pledge agreements, mortgages, guaranties or other loan documents executed in connection therewith. Each Borrower hereby (i) confirms and agrees that each Loan Document to
which it is a party is, and shall continue to be, in full force and effect and is hereby ratified and confirmed in all respects except that on and after the date this Agreement becomes effective all references in any such Loan Document to “the
Loan Agreement”, “thereto”, “thereof”, “thereunder” or words of like import referring to the Original Agreement shall mean the Original Agreement as amended and restated by this Agreement; and (ii) confirms and
agrees that to the extent that the Original Agreement or any Loan Document executed in connection therewith purports to assign or pledge to Silicon or to grant to Silicon a security interest in or lien on, any collateral as security for the
Obligations of Borrowers from time to time existing in respect of the Original Agreement, such pledge, assignment or grant of the security interest or lien is hereby ratified and confirmed in all respects and shall remain effective as of the first
date it became effective. 
  
 9.20 In
handling any confidential information, Silicon will exercise the same degree of care that it exercises for its own proprietary information, but disclosure of information may be made (i) to Silicon’s subsidiaries or affiliates in connection with
their present or prospective business relations with Borrowers, (ii) to prospective transferees or purchasers of any interest in the loans, (iii) as required by law, regulation, subpoena, or other order, (iv) as required in connection with
Silicon’s examination or audit and (v) as Silicon considers appropriate in exercising remedies under this Agreement. Confidential information does not include information that either: (a) is in 
  

 - 32 - 

 the public domain or in Silicon’s possession when disclosed to Silicon, or becomes part of the
public domain after disclosure to Silicon; or (b) is disclosed to Silicon by a third party, if Silicon does not know that the third party is prohibited from disclosing the information. 
  
 [Remainder of page left intentionally blank] 
  
  

 - 33 - 

 This Amended and Restated Loan and Security Agreement is executed by the parties as of the date first set
forth above. 
  

							
	 Borrower:
  
 XENOGEN CORPORATION
	 	 Silicon:
  
 SILICON VALLEY BANK

				
	By	 	  

	 	By	 	  

	 	 	 President or Vice President
	 	Title	 	  

				
	By	 	  

	 	 	 	 
	 	 	 Secretary or Ass’t Secretary
	 	 	 	 
			
	XENOGEN BIOSCIENCES CORPORATION	 	 	 	 
				
	By	 	  

	 	 	 	 
	 	 	 President or Vice President
	 	 	 	 
				
	By	 	  

	 	 	 	 
	 	 	 Secretary or Ass’t Secretary
	 	 	 	 

  
 Signature Page to
Amended and Restated 
 Loan and Security Agreement (Asset Based) 

 Silicon Valley Bank 
  
 Schedule to 
 Loan and Security Agreement 
  
 (Asset Based
Facility) 
  

					
	Borrower:	 	XENOGEN CORPORATION and XENOGEN BIOSCIENCES CORPORATION
			
	Address:	 	860 Atlantic Avenue	 	5 Cedar Brook Drive
	 	 	Alameda, California 94501	 	Cranbury, New Jersey 08512
	Date:	 	August 2, 2005	 	 

  
 This Schedule forms an integral part
of the Loan and Security Agreement between Silicon Valley Bank and the above-borrowers of even date. 
  

					
	1.	  	CREDIT LIMIT	 	 
	 	  	(Section 1.1):	 	An amount not to exceed the lesser of: (i) $13,000,000 at any one time outstanding (the “Maximum Credit Limit”); or (ii) 80% (the “Advance Rate”) of the amount of
Parent’s consolidated Eligible Accounts (as defined in Section 8 above).
			
	 	  	 	 	Silicon may, from time to time, modify the Advance Rate, in its good faith business judgment, upon notice to the Borrowers, based on changes in collection experience with respect to Accounts or
other issues or factors relating to the Accounts or other Collateral.
			
	 	  	Cash Management	 	 
	 	  	Services and Reserves:	 	Borrowers may use up to $1,000,000 of Loans available hereunder for Silicon’s Cash Management Services (as defined below), including, merchant services, business credit card, ACH and other
services identified in the cash management services agreement related to such service (the “Cash Management Services”). Silicon may, in its sole discretion, reserve against Loans which would otherwise be available hereunder such
sums as Silicon shall determine in its good faith business judgment in connection with the Cash Management Services, and Silicon may charge to Borrowers’ Loan account, any amounts that may become

					
	 	  	 	 	due or owing to Silicon in connection with the Cash Management Services. Borrowers agree to execute and deliver to Silicon all standard form applications and agreements of Silicon in connection
with the Cash Management Services, and, without limiting any of the terms of such applications and agreements, Borrowers will pay all standard fees and charges of Silicon in connection with the Cash Management Services. The Cash Management Services
shall terminate on the Maturity Date.
			
	2.	  	INTEREST.	 	 
			
	 	  	Interest Rate (Section 1.2):	 	A rate equal to the “Prime Rate” in effect from time to time, plus 2.50% per annum, provided that the interest rate in effect on any day shall not be less than 6.5% per annum. Interest
shall be calculated on the basis of a 360-day year for the actual number of days elapsed. “Prime Rate” means the rate announced from time to time by Silicon as its “prime rate;” it is a base rate upon which other rates charged by
Silicon are based, and it is not necessarily the best rate available at Silicon. The interest rate applicable to the Obligations shall change on each date there is a change in the Prime Rate.
			
	3.	  	FEES (Section 1.4):	 	 
			
	 	  	Loan Fee:	 	None.
			
	 	  	Collateral Monitoring	 	 
	 	  	Fee:	 	$1,000, per month, payable in arrears (prorated for any partial month at the beginning and at termination of this Agreement) provided, however, that this fee shall be waived if no Loans were
outstanding during the applicable month.
			
	 	  	Unused Line Fee:	 	On the first day of each month and on the Maturity Date, Borrowers agree to pay to Silicon, an unused line fee (the “Unused Line Fee”) equal to the one percent (1%) per annum
times the amount by which (a) $13,000,000 exceeds (b) the greater of: (i) the average daily outstanding amount of Loans and (ii) $5,000,000, during the immediately preceding month or shorter period if calculated on the date this Agreement becomes
effective or on the Maturity Date.

  

 - 2 - 

					
	 	  	 	  	The Unused Line Fee shall be computed on the basis of a 360-day year for the actual number of days elapsed.
			
	4.	  	MATURITY DATE	  	 
			
	 	  	(Section 6.1):	  	August 2, 2007.
			
	5.	  	REPORTING.	  	 
		
	 	  	(Section 5.3): Each Borrower shall provide Silicon with the following:
			
	 	  	 	  	1.Weekly transaction reports and schedules of collections, on Silicon’s standard form.
			
	 	  	 	  	2.Monthly accounts receivable agings, aged by invoice date, within fifteen days after the end of each month.
			
	 	  	 	  	3.Monthly accounts payable agings, aged by invoice date, and outstanding or held check registers, if any, within fifteen days after the end of each month.
			
	 	  	 	  	4.Monthly reconciliations of accounts receivable agings (aged by invoice date), transaction reports, and general ledger, within fifteen days after the end of each month.
			
	 	  	 	  	5.Monthly unaudited financial statements, as soon as available, and in any event within thirty days after the end of each month.
			
	 	  	 	  	6.Monthly Compliance Certificates, within thirty days after the end of each month, in the form of Exhibit A attached hereto or such form as Silicon shall reasonably specify, signed by the Chief
Financial Officer of the Xenogen, certifying that as of the end of such month Borrower was in full compliance with all of the terms and conditions of this Agreement and such other information as Silicon shall reasonably request, including, without
limitation, a statement that at the end of such month there were no held checks.

  

 - 3 - 

					
	 	  	 	  	7.Annual operating budgets (including income statements, balance sheets and cash flow statements, by month) for the upcoming fiscal year of the Borrower within forty-five days prior to the end
of each fiscal year of the Borrower. Such operating budgets must be approved by the Board of Directors.
			
	 	  	 	  	8.Annual financial statements, as soon as available, and in any event within 120 days following the end of Borrower’s fiscal year, certified by, and with an unqualified opinion of,
independent certified public accountants acceptable to Silicon.
			
	 	  	 	  	9.Monthly, within fifteen days after the end of each month, a borrowing base certificate signed by a Chief Financial Officer in the form of Exhibit B (the “Borrowing Base
Certificate”) attached hereto together with a schedule of Deferred Revenue detailing all Deferred Revenue a specifying R & D Deferred Revenue.
			
	6.	  	INTENTIONALLY OMITTED.	  	 
			
	7.	  	ADDITIONAL PROVISIONS:	  	 
			
	 	  	 	  	(1) Banking Relationship. Borrowers shall at all times maintain their primary banking relationship with Silicon. Without limiting the generality of the foregoing, Borrowers shall, at all
times, maintain not less than 85% of its total cash and investments on deposit with Silicon or one of Silicon’s affiliates. As to any Deposit Accounts and investment investment accounts maintained with another institution, each Borrower shall
cause such institution, within 30 days after the date of this Agreement, to enter into a control agreement in form acceptable to Silicon in its good faith business judgment in order to perfect Silicon’s first-priority security interest in said
Deposit Accounts and investment accounts.
			
	 	  	 	  	(2) Subordination of Inside Debt. All present and future indebtedness of Borrowers to its officers, directors and shareholders (“Inside Debt”) shall, at all times, be
subordinated to the Obligations pursuant to a subordination

  

 - 4 - 

			
	 	 	agreement on Silicon’s standard form. Each Borrower represents and warrants that there is no Inside Debt presently outstanding, except for the following:
                    . Prior to incurring any Inside Debt in the future, Borrower shall cause the person to whom such Inside Debt will be owed
to execute and deliver to Silicon a subordination agreement on Silicon’s standard form.
		
	 	 	(3) Financial Covenant. Borrowers will maintain, at all times, a Remaining Months Liquidity Ratio of at least (i) 4.0:1.0 until October 31, 2005 and (ii) 6.0:1.0 thereafter, measured on a
rolling three-month basis For purposes hereof, “Remaining Month’s Liquidity Ratio” means a ratio of (i) unrestricted cash (and equivalents) maintained at Bank or one of its Affiliates (measured at any time) plus 80% of Eligible
Accounts (as measured by the most recently delivered Compliance Certificate) minus any Obligations hereunder to (ii) net income plus depreciation and amortization expenses.

  

							
	Borrower:	 	Silicon:
		
	 XENOGEN CORPORATION
 a
Delaware corporation
	 	 SILICON VALLEY BANK
  

	 	By	 	  

				
	By	 	  

	 	Title	 	  

	 	 	 President or Vice President
	 	 	 	 
				
	By	 	  

	 	 	 	 
	 	 	 Secretary or Ass’t Secretary
	 	 	 	 
			
	XENOGEN BIOSCIENCES CORPORATION	 	 	 	 
	a Delaware corporation	 	 	 	 
				
	By	 	  

	 	 	 	 
	 	 	 President or Vice President
	 	 	 	 
				
	By	 	  

	 	 	 	 
	 	 	 Secretary or Ass’t Secretary
	 	 	 	 

  
  

 - 5 - 

 EXHIBIT A 
  

COMPLIANCE CERTIFICATE 
  

			
	TO:	 	SILICON VALLEY BANK
	FROM:	 	        XENOGEN CORPORATION
	 	 	860 Atlantic Avenue
	 	 	Alameda, California 94501

  
 The undersigned
authorized officer of XENOGEN CORPORATION (“Borrower”) certifies that under the terms and conditions of the Loan and Security Agreement between Borrower and Silicon (the “Agreement”), (i) Borrower is in complete
compliance for the period ending                          with all required covenants except as noted below and (ii) all
representations and warranties in the Agreement are true and correct in all material respects on this date. In addition, the undersigned authorized officer of Borrower certifies that Borrower and each Subsidiary (i) has timely filed all required tax
returns and paid, or made adequate provision to pay, all material taxes, except those being contested in good faith with adequate reserves under GAAP and (ii) does not have any legal actions pending or threatened against Borrower or any Subsidiary
which Borrower has not previously notified in writing to Silicon. Attached are the required documents supporting the certification. The Officer certifies that these are prepared in accordance with Generally Accepted Accounting Principles (GAAP)
consistently applied from one period to the next except as explained in an accompanying letter or footnotes. The Officer acknowledges that no borrowings may be requested at any time or date of determination that Borrower is not in compliance with
any of the terms of the Agreement, and that compliance is determined not just at the date this certificate is delivered. 
  
 Please indicate compliance status by circling Yes/No under “Complies” column. 
  

							
	 Reporting Covenant

	  	 Required

	  	Complies

	Monthly financial statements + CC	  	Monthly within 30 days	  	Yes	    	No
				
	Annual (Audited)	  	FYE within 120 days	  	Yes	    	No
				
	A/R, A/P Agings, Deferred Revenue Schedule, and Borrowing Base Certificate	  	Monthly within 30 days	  	Yes	    	No
				
	Financial Projections	  	Initial and FYE within 45 days	  	Yes	    	No
				
	A/R Audit	  	Three times per year	  	Yes	    	No

  

									
	 Covenants

	  	Minimum

	  	Actual

	  	Trigger

	 Remaining Month’s Liquidity Ratio
	  	6.0:1.0	  	    :1.00	  	Yes	  	    No    

 Borrower only has deposit accounts located at the following institutions:
                        . 
  
 Comments Regarding Exceptions: See Attached. 
  

	
	Sincerely,
	
	XENOGEN CORPORATION
	  

	SIGNATURE
	  

	TITLE

 EXHIBIT B 
  

BORROWING BASE CERTIFICATE 
  

							
	Borrower:	 	 Xenogen Corporation
  
 860 Atlantic Avenue
  
 Alameda, CA 94501
	  	Bank:	 	 Silicon Valley Bank
  
 3003 Tasman Drive
  
 Santa Clara, CA 95054

  
 Commitment Amount: $13,000,000

  
 ACCOUNTS RECEIVABLE 
  

	1.	Accounts Receivable Book Value as of             
$                 

  

	2.	Additions (please explain on reverse) $                 

  

	3.	TOTAL ACCOUNTS RECEIVABLE $                 

  
 ACCOUNTS RECEIVABLE DEDUCTIONS (without duplication) 
  

	4.	Amounts over 90 days due $                 

  

	5.	Balance of 50% over 90 day accounts $                 

  

	6.	Credit balances over 90 days $                 

  

	7.	Concentration Limits $                 

  

	8.	Foreign Accounts $                 

  

	9.	Governmental Accounts $                 

  

	10.	Contra Accounts $                 

  

	11.	Promotion or Demo Accounts
            $                 

  

	12.	Intercompany/Employee Accounts      $                

  

	13.	Undelivered Goods or Services
          $                 

  

	14.	Progress Payments and Advance Billings $                 

  

	15.	R&D Offset $                 

  

	16.	Other (please explain on reverse) $                 

  

	17.	TOTAL ACCOUNTS RECEIVABLE DEDUCTIONS $                 

  

	18.	Eligible Accounts (#3 minus #17) $                 

  

	19.	LOAN VALUE OF ACCOUNTS (80% of #18) $                 

  
 BALANCES 
  

	20.	Maximum Loan Amount $                 

  

	21.	Total Funds Available [Lesser of #20 or #19] $                 

  

	22.	Present balance owing on Line of Credit $                 

  

	23.	Outstanding under Sublimits $                 

  
 RESERVE POSITION (#21 minus #22 and #23)
$                 
  
 The undersigned represents and warrants that this is true, complete and correct, and that the information in this Borrowing Base Certificate complies with the representations and warranties in the Loan and Security
Agreement between the undersigned and Silicon Valley Bank. 

							
	COMMENTS	 	BANK USE ONLY
			
	XENOGEN CORPORATION	 	Rec’d By	 	  

	By:	 	  

	 	 	 	 Authorized Signer

	 Authorized Signer
	 	Date:	 	  

				
	 	 	 	 	Verified:	 	  

	 	 	 	 	 	 	 Authorized Signer

				
	 	 	 	 	Date:	 	  

  
  

 EXHIBIT C 
  

REPRESENTATIONS AND WARRANTIES 
  

			
	TO:	 	SILICON VALLEY BANK
		
	 	 	Commercial Finance Division
		
	 	 	3003 Tasman Drive
		
	 	 	Mail Sort NC491
		
	 	 	Santa Clara, California 95054

  
 The undersigned,
Xenogen Corporation, a Delaware corporation (the “Company”) hereby represents and warrants to you that the following information is true, accurate and complete. (The Company acknowledges that your acceptance of these Representations and
Warranties does not imply any commitment on your part to enter into a loan transaction with the Company, and that any such commitment may only be made by an express written loan commitment, signed by one of your authorized officers.) 
  
 1. NAMES OF THE COMPANY 
  
 A. The exact corporate name of the Company as it appears in its current
Articles or Certificate of Incorporation is as follows:               
  
 B. The federal employer identification number of the Company is as follows:
             
  
 C. The Company was incorporated on              under the laws of the State of
             and is in good standing under those laws. 
  
 D. The following is a list of all other names (including fictitious names, d/b/a’s, trade names or similar names) currently used by the Company or
used within the past six years: 
  

			
	 Name

	 	 Period of Use

 The following are the names of all corporations which have been merged into the Company during the past
six years: 
  

			
	 Name of Merged Company

	 	 Year of Merger

	_______	 	_______
		
	_______	 	_______

  
 E. The following are
the names and addresses of all entities from whom the Company has acquired any personal property in a transaction not in the ordinary course of business during the past six years, together with the date of such acquisition and the type of personal
property acquired (e.g., equipment, inventory, etc.): 
  

							
	 Name

	 	 Street and Mailing Address

	 	 Date of Acquisition

	  	Type of Property

	_______	 	_______	 	_______	  	_______
				
	_______	 	_______	 	_______	  	_______
				
	_______	 	_______	 	_______	  	_______

  
 2. NAMES OF
SUBSIDIARIES/PARENT OF THE COMPANY. 
  
 A. The exact
corporate name of each subsidiary and parent of the Company is as follows. (A “parent” is a company owning more than 50% of the outstanding capital stock of the Company.) 
  

					
	 Name

	  	 Subsidiary/Parent

	 	 Fed. Employer ID No.

	_______	  	Sub   ̈  Parent  ̈	 	_______
			
	_______	  	Sub   ̈  Parent  ̈	 	_______
			
	_______	  	Sub   ̈  Parent  ̈	 	_______

 B. The following is a list of the jurisdiction and date of incorporation of each subsidiary of the
Company: 
  

					
	 Name

	  	Jurisdiction

	  	Date of Incorporation

	_______	  	_______	  	_______
			
	_______	  	_______	  	_______
			
	_______	  	_______	  	_______

  
 C. The following is a
list of all other names (including fictitious names, d/b/a’s, trade names or similar names) used by each subsidiary of the Company during the past six years: 
  

					
	 Name

	 	Subsidiary

	 	 
	_______	 	_______	 	 
			
	_______	 	_______	 	 
			
	_______	 	_______	 	 

  
 D. The following are
the names of all corporations which have been merged into a subsidiary of the Company during the six years: 
  

					
	 Name

	  	Subsidiary

	  	 
	_______	  	_______	  	 
			
	_______	  	_______	  	 
			
	_______	  	_______	  	 

  
 E. The following are
the names and addresses of all entities from whom each subsidiary of the Company has acquired any personal property in a transaction not in the ordinary course of business during the past six years, together with the date of such acquisition and the
type of personal property acquired (e.g., equipment, inventory, etc.): 
  

									
	 Name

	  	Mailing
Address

	  	Date of
Acquisition

	  	Type of
Property

	  	Subsidiary

	_______	  	_______	  	_______	  	_______	  	_______
					
	_______	  	_______	  	_______	  	_______	  	_______
					
	_______	  	_______	  	_______	  	_______	  	_______

 3. LOCATIONS OF COMPANY AND ITS SUBSIDIARIES. 
  
 A. The chief executive offices of the Company and its subsidiaries are
presently located at the following addresses: 
  

			
	 Complete Street and Mailing Address, including County and Zip Code

	 	 Company/Subsidiary

	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub

  
 B. During the past six
years, the Company’s chief executive office and the chief executive offices of its subsidiaries have been located at the following additional addresses: 
  

			
	 Complete Street and Mailing Address, including County and Zip Code

	 	 Company/Subsidiary

	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub

 C. The following are all the locations in the United States where the Company and its subsidiaries
maintain any books or records relating to any of their accounts receivable: 
  

			
	 Complete Street and Mailing Address, including County and Zip Code

	 	 Company/Subsidiary

	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub

  

			
	 Complete Street and Mailing Address, including County and Zip Code

	 	 Company/Subsidiary

	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub

  
 D. The following are
all of the locations in the United States where the Company and its subsidiaries maintain any equipment, fixtures, inventory or other property: 
  

			
	 Complete Street and Mailing Address, including County and Zip Code

	 	 Company/Subsidiary

	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub

 E. The following are all the locations in the United States where the Company and its subsidiaries own,
lease, or occupy any real property: 
  

			
	 Complete Street and Mailing Address, including County and Zip Code

	 	 Company/Subsidiary

	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub
		
	_______	 	Company  ̈  OR Name of Sub

  
 The following are the
names and addresses of all warehousemen or bailees who have possession of any of the Company’s inventory or any of the inventory of its subsidiaries: 
  

					
	 Name

	  	 Complete Street and Mailing Address, including County and Zip Code

	 	 Company/Subsidiary

	 _______
	  	        _______	 	Company  ̈  OR Name of Sub
			
	 _______
	  	        _______	 	Company  ̈  OR Name of Sub
			
	 _______
	  	        _______	 	Company  ̈  OR Name of Sub
			
	 _______
	  	        _______	 	Company  ̈  OR Name of Sub

  
 4. SPECIAL TYPES
OF COLLATERAL 
  
 The Company and its subsidiaries own the
following kinds of assets. (If the answer is “Yes” to any of the following questions, attach a schedule describing each such asset owned by the Company or its subsidiaries and identifying which party owns the asset.) 

							
	 Copyrights or copyright applications registered with the U.S. Copyright Office
	  	Yes 	 ̈	 	No 	 ̈
	 Software registered with the U.S. Copyright Office
	  	Yes 	 ̈	 	No 	 ̈
	 Software not registered with the U.S. Copyright Office
	  	Yes 	 ̈	 	No 	 ̈
	 Patents and patent applications
	  	Yes 	 ̈	 	No 	 ̈
	 Trademarks or trademark applications (including any service marks, collective marks and certification marks)
	  	Yes 	 ̈	 	No 	 ̈
	 Licenses to use trademarks, patents and copyrights of others
	  	Yes 	 ̈	 	No 	 ̈
	 Franchise, marketing agreements or similar agreements:
	  	Yes 	 ̈	 	No 	 ̈
	 Stocks, Bonds or other securities:
	  	Yes 	 ̈	 	No 	 ̈
	 Promissory notes, or other instruments or evidence of indebtedness:
	  	Yes 	 ̈	 	No 	 ̈
	 Leases of equipment, security agreements naming such person as secured party, or other chattel paper:
	  	Yes 	 ̈	 	No 	 ̈
	 Aircraft:
	  	Yes 	 ̈	 	No 	 ̈
	 Vessels, Boats or Ships:
	  	Yes 	 ̈	 	No 	 ̈
	 Railroad Rolling Stock
	  	Yes 	 ̈	 	No 	 ̈
	 Motor Vehicles
	  	Yes 	 ̈	 	No 	 ̈

  
 A. The following are
all governmental permits and licenses held by the Company and its subsidiaries: 
  

									
	 Description of License

	 	 	 	 Company/Subsidiary

	 _______
	 	 	 	Company  ̈  OR Name of Sub
					
	 _______
	 	 	 	 _______
	 	 _______
	 	Company  ̈  OR Name of Sub
					
	 _______
	 	 	 	 _______
	 	_______	 	Company  ̈  OR Name of Sub

  
 5. OFFICERS OF
THE COMPANY AND ITS SUBSIDIARIES 
  
 The
following are the names and titles of the officers of the Company and its Subsidiaries. 
  

 82 

					
	 Office/Title

	  	 Name of Officer

	  	 Company/Subsidiary

	 _________
	  	 _________
	  	Company  ̈  OR Name of Sub
			
	 _________
	  	 _________
	  	Company  ̈  OR Name of Sub
			
	 _________
	  	 _________
	  	Company  ̈  OR Name of Sub
			
	 _________
	  	 _________
	  	Company  ̈  OR Name of Sub
			
	 _________
	  	 _________
	  	Company  ̈  OR Name of Sub
			
	 _________
	  	 _________
	  	Company  ̈  OR Name of Sub

  
 6. LEGAL
COUNSEL. 
  
 The following firm will represent the
Company in connection with the loan documents: 
  

									
	 Attorney

	 	 Law Firm

	 	 Telephone

	  	Fax

	  	Email

	 _________
	 	 _________
	 	 _________
	  	_________	  	_________

  
 The undersigned
undertakes to advise you of any change or modification to any of the foregoing information. Until such notice is received by you, you shall be entitled to rely upon all of the foregoing and presume it is correct and accurate in all respects.

  

					
	 Date:                     ,
200    
	 	XENOGEN CORPORATION
			
	 	 	By:	 	  

	 	 	Its:	 	 
	 	 	Email:	 	 

  
  

 Continuation Page—Additional Information 
  
  

 EXHIBIT E 
  

INVESTMENT POLICY 
  
 Xenogen Corporation 
  
 Amended Investment Guidelines1 

	I.	Purpose 

  
 These investment guidelines have been adopted by the Board of Directors of Xenogen Corporation in order to establish policy and guidelines for investing
surplus corporate cash, with the goal of capital preservation and liquidity. All investments must be made in compliance with these guidelines, the Investment Company Act of 1940 (the “1940 Act”) and the non-exclusive safe harbor for
research and development companies set forth in rule 3a-8 of the 1940 Act. 
  
 “Surplus cash” is cash not required for short-term debt repayment, working capital, capital investment, or other outstanding near-term financial obligations. 
  
 Objectives 
  
 The key objectives of the company investment policy are the preservation of capital and maintenance of appropriate
short-term liquidity. 
  
 More specifically: 
  

	 	A.	Preserve capital; 

  

	 	B.	Maintain sufficient liquidity to meet forecasted cash needs; 

  

	 	C.	Maintain diversified portfolio of investments in order to minimize the concentration risks; 

  

	 	D.	Maximize yield on investments within the parameters set forth below; 

  

	 	E.	Establish fiduciary control of cash and investments. 

  

	II.	Liquidity Guidelines 

  
 Excess cash is invested with liquidity in mind, and without any loss of principal. 
  
 Daily liquidity is essential; restrictions on liquidity are: 
  

	 	1.	Twice the amount of the monthly burn must be available each business day with no loss of principal. 

	1	Guidelines originally adopted by the Board on July 22, 2003; Amended and Restated Guidelines adopted by the Audit Committee on October 21, 2004

	 	2.	The remainders of the funds are to be invested, consistent with anticipated cash needs, in securities with maturities no longer than 24 months. The weighted-average-maturity cannot
exceed 12-months. Repositioning of these securities before their maturity, generating small gains or losses, is permitted for managing liquidity requirements only. Any loss from such repositioning can only be incurred if the gain in the previous
three months fully offsets this loss. 

  

	III.	Investment Restrictions 

  
 Investments shall be made in the context of the following investment guidelines. 
  

	 	A.	Investment Portfolio 

  

	 	1.	No more than 10 percent of the company’s total assets may consist of investments other than Capital Preservation Investments (defined below). 

  

	 	B.	Capital Preservation Investments 

  

	 	1.	Direct obligations of the U.S. Treasury, including bills, notes, and bonds. 

  

	 	2.	Obligations issued or guaranteed by agencies or instrumentalities of the U.S. government. 

  

	 	3.	Municipal securities (taxable and tax-exempt, when appropriate), including variable rate demand notes and auction rate municipals. 

  

	 	4.	Bank obligations, including certificates of deposit, bank notes, and bankers acceptances. 

  

	 	5.	Corporate obligations, including commercial paper, corporate notes, medium-term notes and corporate bonds. 

  

	 	6.	Repurchase agreements collateralized at a minimum of 102% with U.S. Treasury securities or other securities rated “AAA” or equivalent that would be permitted by this
policy. 

  

	 	7.	Money market funds over $1 billion in assets (must be AAA-rated), with an historically constant dollar net asset value, consisting of acceptable securities as stated above are
appropriate for investing, as long as the fund’s manager has been in business over five years, has name recognition, and has performance that is easily tracked. 

  

	 	8.	U.S. dollar-denominated international corporate debt of all types is acceptable as long as the issuer meets credit rating and marketability guidelines. 

  

	 	9.	Derivative instruments are ineligible as investments. This would cover all investments where the value is based on an underlying variable causing the coupon and/or the maturity
value to be unknown for the life of the security. 

	 	C.	Credit Quality 

  

	 	1.	In all categories described above, the emphasis will be on securities of high credit quality. 

  

	 	2.	Investments which bear a short-term credit rating must be explicitly rated by two of the three following rating services: A1 by Standard & Poor’s, P1 by Moody’s
and/or F-1 by Fitch (no split-rated paper permitted). 

  

	 	3.	Investments which bear a long-term credit rating must be explicitly rated by two of the following rating services: A by Standard & Poor’s, A2 by Moody’s
and/or A by Fitch. 

  

	 	4.	Investments which bear an AAA-rating may only be rated by one of the three rating agencies. 

  

	IV.	Maturities 

  
 The maximum maturity of individual securities in the portfolio may not exceed Twenty-four (24) months. 
  
 The dollar-weighted-average maturity of the portfolio may not exceed twelve
(12) months. 
  
 For securities which have put dates, reset dates
or auction dates, the put date, reset date or auction date will be used, instead of the final maturity date, for maturity guideline purposes. 
  

	V.	Concentration Limits/Restrictions 

  
 There is no limit to the percentage of the portfolio which may be maintained in securities issued by the U.S. Treasury or by its agencies and
instrumentalities. 
  
 No one issuer or group of issuers from the
same holding company is to exceed 10% of the portfolio or $1.0 million, whichever is greater of the portfolio at time of purchase, with the exception of Government securities. 
  
 AND, no more than 10% of the total issue size outstanding at time of purchase. 
  
 Any investment in common stocks, preferred stocks, options (put or calls),
commodities, foreign securities, futures or mutual funds whose underlying securities are not considered Capital Preservation Investments must comply with Part III.A of this policy. 
  

	VI.	Investment Performance 

  
 The company shall review the performance of the selected investment-banking group on quarterly basis. The investment banks will issue separate quarterly
investment performance analysis using time-weighted measures. 
  
 The net income derived from investments for the last four fiscal quarters combined may not exceed twice the amount of the company’s research and development expenses for the same period. 

 Expenses for investment advisory and management activities, investment research and custody for the last
four fiscal quarters combined may not exceed five percent of the company’s total expenses for the same period. 
  

	VII.	Marketability 

  
 All securities are to be purchased through investment banking and brokerage firms of high quality and reputation, with a history of making markets for the
securities in which we invest. In the unlikely event that securities must be sold before their maturity, the securities must be easily re-marketed. To accomplish this, the securities must be conventional “products” with strong name
recognition. 
  

	VIII.	Trading Guidelines 

  
 Normal investing practice is to reinvest the funds on the day a security matures, to minimize lost interest. A daily transaction log is to be maintained
and available for review at any time. All trading firms must generate a hard copy document for each transaction which is mailed to us on a timely basis, and then matched to the transaction log. Quarterly summaries of our investment holdings and cash
usage are to be made available for Board review. 
  

	IX.	Communication 

  
 The investment manager will contact the Chief Financial Officer immediately upon the occurrence of any of the following events:

  

	 	A.	An issuer is placed on “CreditWatch” with Negative Implications” and/or on “Negative Outlook” whereby any whereby any potential action could result in a
credit rating cut; 

  

	 	B.	A decline in the issuer’s credit rating below the minimum credit quality standards stated in this Investment Policy. 

  

	 	C.	Research and development expenses for the last four fiscal quarters combined are no longer a substantial percentage of the company’s total expenses for the same period.

  

	 	D.	The company is not in compliance with any of these guidelines. 

  

	X.	Safekeeping 

  
 Assets/investment securities are to be held in segregated bank account; they cannot be co-mingled. Assets/investment securities can be held by the
investment manager as long as the manager’s minimum long-term rating is A2 by Moody’s and A by S&P. 

	XI.	Fiduciary Discretion 

  
 The Chief Financial Officer or other individual appointed by the Board and his/her authorized employees are responsible for securing and managing
investments and cash for operations. These individuals have full discretion to invest any excess capital subject to strict adherence to these guidelines. These guidelines and the performance of the investments are to be reviewed periodically with
the Board of Directors and only then can guideline revisions be made. 
  

							
	By:	 	  

	  	Title:	 	  

 CORPORATE BORROWING RESOLUTION 
  

							
	Borrower:	  	 XENOGEN CORPORATION
  
 860 Atlantic Avenue
 Alameda, California 94501
	  	Bank:	  	 Silicon Valley Bank
  
 3003 Tasman Drive
 Santa Clara, CA
95054-1191

  
 I, the Secretary or Assistant
Secretary of Xenogen Corporation (“Borrower”), CERTIFY that Borrower is a corporation existing under the laws of the State of Delaware. 
  
 I certify that at a meeting of Borrower’s Directors (or by other authorized corporate action) duly held the following resolutions were adopted. 
  
 It is resolved that any one of the following officers of Borrower, whose name, title
and signature is below: 
  

					
	 NAMES

	 	 POSITIONS

	 	 ACTUAL SIGNATURES

	_________________________	 	_________________________	 	_________________________
			
	_________________________	 	_________________________	 	_________________________
			
	_________________________	 	_________________________	 	_________________________
			
	_________________________	 	_________________________	 	_________________________

  
 may act for Borrower and: 

 
 Borrow Money. Borrow money from Silicon Valley Bank (“Bank”). 

 
 Execute Loan Documents. Execute any loan documents Bank requires. 
  
 Grant Security. Grant Bank a security interest in any of Borrower’s assets.

  
 Negotiate Items. Negotiate or discount all drafts, trade acceptances,
promissory notes, or other indebtedness in which Borrower has an interest and receive cash or otherwise use the proceeds. 
  
 Letters of Credit. Apply for letters of credit from Bank. 
  
 Foreign Exchange Contracts. Execute spot or forward foreign exchange contracts. 
  

 -i- 

 Further Acts. Designate other individuals to request advances, pay fees and costs and execute other documents or
agreements (including documents or agreement that waive Borrowers right to a jury trial) they think necessary to effectuate these Resolutions. 
  
 Further resolved that all acts authorized by these Resolutions and performed before they were adopted are ratified. These Resolutions remain in effect and Bank may
rely on them until Bank receives written notice of their revocation. 
  
 I
certify that the persons listed above are Borrower’s officers with the titles and signatures shown following their names and that these resolutions have not been modified are currently effective. 
  

			
	CERTIFIED TO AND ATTESTED BY:
		
	X	 	  

	 	 	*Secretary or Assistant Secretary
		
	X	 	  

	*	NOTE: In case the Secretary or other certifying officer is designated by the foregoing resolutions as one of the signing officers, this resolution should also be signed by a second
Officer or Director of Borrower. 

  
  

 -ii- 

 CORPORATE BORROWING RESOLUTION 
  

							
	Borrower:	 	 XENOGEN BIOSCIENCES CORPORATION
  
 860 Atlantic Avenue
 Alameda, California 94501
	  	Bank:	 	 Silicon Valley Bank
  
 3003 Tasman Drive
 Santa Clara, CA
95054-1191

  
 I, the Secretary or Assistant
Secretary of Xenogen Biosciences Corporation (“Borrower”), CERTIFY that Borrower is a corporation existing under the laws of the State of Delaware. 
  
 I certify that at a meeting of Borrower’s Directors (or by other authorized corporate action) duly held the following
resolutions were adopted. 
  
 It is resolved that any one of the following
officers of Borrower, whose name, title and signature is below: 
  

					
	 NAMES

	 	 POSITIONS

	 	 ACTUAL SIGNATURES

	_________________________	 	_________________________	 	_________________________
			
	_________________________	 	_________________________	 	_________________________
			
	_________________________	 	_________________________	 	_________________________
			
	_________________________	 	_________________________	 	_________________________

  
 may act for Borrower and: 

 
 Borrow Money. Borrow money from Silicon Valley Bank (“Bank”). 

 
 Execute Loan Documents. Execute any loan documents Bank requires. 
  
 Grant Security. Grant Bank a security interest in any of Borrower’s assets.

  
 Negotiate Items. Negotiate or discount all drafts, trade acceptances,
promissory notes, or other indebtedness in which Borrower has an interest and receive cash or otherwise use the proceeds. 
  
 Letters of Credit. Apply for letters of credit from Bank. 
  
 Foreign Exchange Contracts. Execute spot or forward foreign exchange contracts. 
  

 -iii- 

 Further Acts. Designate other individuals to request advances, pay fees and costs and execute other documents or
agreements (including documents or agreement that waive Borrowers right to a jury trial) they think necessary to effectuate these Resolutions. 
  
 Further resolved that all acts authorized by these Resolutions and performed before they were adopted are ratified. These Resolutions remain in effect and Bank may
rely on them until Bank receives written notice of their revocation. 
  
 I
certify that the persons listed above are Borrower’s officers with the titles and signatures shown following their names and that these resolutions have not been modified are currently effective. 
  

			
	CERTIFIED TO AND ATTESTED BY:
		
	X	 	  

	*Secretary or Assistant Secretary
		
	X	 	  

	*	NOTE: In case the Secretary or other certifying officer is designated by the foregoing resolutions as one of the signing officers, this resolution should also be signed by a second
Officer or Director of Borrower. 

  

 -iv-

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