Document:

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                                                                Exhibit No. 4(d)

                 INVESTMENT ADVISORY AND ADMINISTRATION CONTRACT

         Contract made as of February 1, 2000 between MITCHELL HUTCHINS LIR
MONEY SERIES, a Delaware business trust ("Trust"), and MITCHELL HUTCHINS ASSET
MANAGEMENT INC. ("Mitchell Hutchins"), a Delaware corporation registered as a
broker-dealer under the Securities Exchange Act of 1934, as amended ("1934
Act"), and as an investment adviser under the Investment Advisers Act of 1940,
as amended.

         WHEREAS the Trust is registered under the Investment Company Act of
1940, as amended ("1940 Act"), as an open-end investment management company, and
intends to offer for public sale a distinct series of shares of beneficial
interest, LIR Liquid Assets Fund, corresponding to a distinct portfolio; and

         WHEREAS the Trust desires to retain Mitchell Hutchins as investment
adviser and administrator to furnish certain administrative, investment advisory
and portfolio management services to the Trust with respect to LIR Liquid Assets
Fund and any other Series to which this Contract may hereafter be made
applicable (each a "Series"), and Mitchell Hutchins is willing to furnish such
services;

         NOW, THEREFORE, in consideration of the premises and mutual covenants
herein contained, it is agreed between the parties hereto as follows:

         1.   APPOINTMENT. The Trust hereby appoints Mitchell Hutchins as
investment adviser and administrator of the Trust with respect to each Series
for the period and on the terms set forth in this Contract. Mitchell Hutchins
accepts such appointment and agrees to render the services herein set forth, for
the compensation herein provided.

         2.   DUTIES AS INVESTMENT ADVISER.

         (a)  Subject to the supervision of the Trust's Board of Trustees
("Board"), Mitchell Hutchins will provide a continuous investment program for
each Series, including investment research and management with respect to all
securities and investments and cash equivalents in each Series. Mitchell
Hutchins will determine from time to time what securities and other investments
will be purchased, retained or sold by each Series.

         (b)  Mitchell Hutchins agrees that in placing orders with brokers, it
will attempt to obtain the best net result in terms of price and execution;
provided that, on behalf of any Series, Mitchell Hutchins may, in its
discretion, use brokers who provide the Series with research, analysis, advice
and similar services to execute portfolio transactions on behalf of the Series,
and Mitchell Hutchins, pursuant to Board authorization, may pay to those brokers
in return for brokerage and research services a higher commission than may be
charged by other brokers, subject to Mitchell Hutchins' determining in good
faith that such commission is reasonable in terms either of the particular
transaction or of the overall responsibility of Mitchell Hutchins to such Series
and its

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other clients and that the total commissions paid by such Series will be
reasonable in relation to the benefits to the Series over the long term. In no
instance will portfolio securities be purchased from or sold to Mitchell
Hutchins, or any affiliated person thereof, except in accordance with the
federal securities laws and the rules and regulations thereunder. Whenever
Mitchell Hutchins simultaneously places orders to purchase or sell the same
security on behalf of a Series and one or more other accounts advised by
Mitchell Hutchins, such orders will be allocated as to price and amount among
all such accounts in a manner believed to be equitable to each account. The
Trust recognizes that in some cases this procedure may adversely affect the
results obtained for the Series.

         (c)  Mitchell Hutchins will oversee the maintenance of all books and
records with respect to the securities transactions of each Series, and will
furnish the Board with such periodic and special reports as the Board reasonably
may request. In compliance with the requirements of Rule 31a-3 under the 1940
Act, Mitchell Hutchins hereby agrees that all records which it maintains for the
Trust are the property of the Trust, agrees to preserve for the periods
prescribed by Rule 31a-2 under the 1940 Act any records which it maintains for
the Trust and which are required to be maintained by Rule 31a-1 under the 1940
Act and further agrees to surrender promptly to the Trust any records which it
maintains for the Trust upon request by the Trust.

         (d)  Mitchell Hutchins will oversee the computation of the net asset
value and the net income of each Series as described in the currently effective
registration statement of the Trust under the Securities Act of 1933, as
amended, and the 1940 Act and any supplements thereto ("Registration Statement")
or as more frequently requested by the Board.

         (e)  The Trust hereby authorizes Mitchell Hutchins and any entity or
person associated with Mitchell Hutchins which is a member of a national
securities exchange to effect any transaction on such exchange for the account
of any Series, which transaction is permitted by Section 11(a) of the 1934 Act,
and the Trust hereby consents to the retention of compensation by Mitchell
Hutchins or any person or entity associated with Mitchell Hutchins.

         3.   DUTIES AS ADMINISTRATOR. Mitchell Hutchins will administer the
affairs of the Trust with respect to each Series subject to the supervision of
the Board and the following understandings:

         (a)  Mitchell Hutchins will supervise all aspects of the operations of
the Trust and each Series, including oversight of transfer agency, custodial and
accounting services, except as hereinafter set forth; provided, however, that
nothing herein contained shall be deemed to relieve or deprive the Board of its
responsibility for and control of the conduct of the affairs of the Trust and
each Series.

         (b)  Mitchell Hutchins will provide the Trust and each Series with such
corporate, administrative and clerical personnel (including officers of the
Trust) and services as are reasonably deemed necessary or advisable by the
Board, including the maintenance of certain books and records of the Trust and
each Series.

         (c)  Mitchell Hutchins will arrange, but not pay, for the periodic
preparation, updating, filing and dissemination (as applicable) of the Trust's
Registration Statement, proxy material, tax

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returns and required reports to each Series' shareholders and the Securities and
Exchange Commission and other appropriate federal or state regulatory
authorities.

         (d)  Mitchell Hutchins will provide the Trust and each Series with, or
obtain for it, adequate office space and all necessary office equipment and
services, including telephone service, heat, utilities, stationery supplies and
similar items.

         (e)  Mitchell Hutchins will provide the Board on a regular basis with
economic and investment analyses and reports and make available to the Board
upon request any economic, statistical and investment services normally
available to institutional or other customers of Mitchell Hutchins.

         4.   FURTHER DUTIES. In all matters relating to the performance of this
Contract, Mitchell Hutchins will act in conformity with the Trust Instrument,
By-Laws and Registration Statement of the Trust and with the instructions and
directions of the Board and will comply with the requirements of the 1940 Act,
the rules thereunder, and all other applicable federal and state laws and
regulations.

         5.   DELEGATION OF MITCHELL HUTCHINS' DUTIES AS INVESTMENT ADVISER AND
ADMINISTRATOR. With respect to any or all Series, Mitchell Hutchins may enter
into one or more contracts ("Sub-Advisory or Sub-Administration Contract") with
a sub-adviser or sub-administrator in which Mitchell Hutchins delegates to such
sub-adviser or sub-administrator any or all its duties specified in Paragraphs 2
and 3 of this Contract, provided that each Sub-Advisory or Sub-Administration
Contract imposes on the sub-adviser or sub-administrator bound thereby all
applicable duties and conditions to which Mitchell Hutchins is subject by
Paragraphs 2, 3 and 4 of this Contract, and further provided that each
Sub-Advisory or Sub-Administration Contract meets all requirements of the 1940
Act and rules thereunder.

         6.   SERVICES NOT EXCLUSIVE. The services furnished by Mitchell
Hutchins hereunder are not to be deemed exclusive and Mitchell Hutchins shall be
free to furnish similar services to others so long as its services under this
Contract are not impaired thereby. Nothing in this Contract shall limit or
restrict the right of any director, officer or employee of Mitchell Hutchins,
who may also be a Trustee, officer or employee of the Trust, to engage in any
other business or to devote his or her time and attention in part to the
management or other aspects of any other business, whether of a similar nature
or a dissimilar nature.

         7.   EXPENSES.

         (a)  For the services provided and expenses assumed pursuant to this
Contract with respect to the Series, the Trust will pay to Mitchell Hutchins a
fee, computed daily and paid monthly. Where the services are provided directly
by Mitchell Hutchins or an affiliate, the fees will be limited to reimbursement
of Mitchell Hutchins' direct administrative costs and expenses and will exclude
any profit or overhead charges. Where Mitchell Hutchins arranges for an
unaffiliated person to provide services, the Trust will reimburse Mitchell
Hutchins for the cost of the services provided by the unaffiliated person, but
no additional profit or overhead charge will be included. (Hereinafter, the fees
and expenses payable by the Fund under this Paragraph 7(a)

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are referred to as "Direct Expenses.")

         (b)  Subject to Paragraph 7(a), the Direct Expenses borne by each
Series will include but not be limited to the following (or each Series'
proportionate share of the following): (i) expenses of paying the salaries and
expenses of the Trust's officers and other personnel engaged in administering
the Trust's business; (ii) expenses of monitoring financial and shareholder
accounting services provided by the Trust's custodian and transfer agent,
respectively; (iii) expenses of responding to shareholder inquiries and
disseminating information to shareholders; (iv) expenses of monitoring
compliance with the Trust's registration statements and other operating
documents, with federal and state securities laws and rules thereunder and with
the Internal Revenue Code of 1986, as amended; (v) expenses of preparing
semi-annual and annual reports to shareholders; (vi) expenses of preparing
filings required by the SEC; (vii) expenses of preparing federal, state and
local tax returns; (viii) expenses of paying notice filing fees under state
securities laws; (ix) expenses of organizing annual and special meetings of
shareholders; (x) the cost (including brokerage commissions) of securities
purchased or sold by the Series and any losses incurred in connection therewith;
(xi) expenses incurred on behalf of the Series by Mitchell Hutchins under this
Contract; (xii) expenses of organizing the Trust and the Series; (xiii) filing
fees and expenses relating to the registration and qualification of the Series'
shares and the Trust under federal and/or state securities laws and maintaining
such registration and qualifications; (xiv) fees and salaries payable to the
Trust's Trustees and officers who are not interested persons of the Trust or
Mitchell Hutchins; (xv) all expenses incurred in connection with the Trustees'
services, including travel expenses; (xvi) taxes (including any income or
franchise taxes) and governmental fees; (xvii) costs of any liability,
uncollectible items of deposit and other insurance and fidelity bonds; (xviii)
any costs, expenses or losses arising out of a liability of or claim for damages
or other relief asserted against the Trust or Series for violation of any law;
(xix) legal, accounting and auditing expenses, including legal fees of special
counsel for those Trustees of the Trust who are not interested persons of the
Trust; (xx) charges of custodians, transfer agents and other agents (including
any lending agent); (xxi) costs of preparing share certificates; (xxii) expenses
of setting in type and printing prospectuses and supplements thereto, statements
of additional information and supplements thereto, reports and proxy materials
for existing shareholders; (xxiii) costs of mailing prospectuses and supplements
thereto, statements of additional information and supplements thereto, reports
and proxy materials to existing shareholders; (xxiv) any extraordinary expenses
(including fees and disbursements of counsel, costs of actions, suits or
proceedings to which the Trust is a party and the expenses the Trust may incur
as a result of its legal obligation to provide indemnification to its officers,
Trustees, agents and shareholders) incurred by the Trust or Series; (xxv) fees,
voluntary assessments and other expenses incurred in connection with membership
in investment company organizations; (xxvi) the cost of mailing and tabulating
proxies and costs of meetings of shareholders, the Board and any committees
thereof; (xxvii) the cost of investment company literature and other
publications provided by the Trust to its Trustees and officers; (xxviii) costs
of mailing, stationery and communications equipment; (xxix) expenses incident to
any dividend, withdrawal or redemption options; (xxx) charges and expenses of
any outside pricing service used to value portfolio securities; and (xxxi)
interest on borrowings of the Series; and (xxxii) any other costs and expenses
incurred in managing the portfolio of a Series.

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         (c)  The Trust or a Series may pay directly any Direct Expense incurred
by it in its normal operations and, if any such payment is consented to by
Mitchell Hutchins and acknowledged as otherwise payable by Mitchell Hutchins
pursuant to this Contract, the Series may reduce any amounts otherwise payable
to Mitchell Hutchins pursuant to this Contract. To the extent that such
deductions exceed the amounts payable to Mitchell Hutchins on any monthly
payment date, such excess shall be carried forward and deducted in the same
manner from the fee payable on succeeding monthly payment dates.

         (d)  Mitchell Hutchins will assume the cost of any compensation for
services provided to the Trust received by the officers of the Trust and by
those Trustees who are interested persons of the Trust.

         (e)  The payment or assumption by Mitchell Hutchins of any expenses of
the Trust or a Series that Mitchell Hutchins is not required by this Contract to
pay or assume shall not obligate Mitchell Hutchins to pay or assume the same or
any similar expense of the Trust or a Series on any subsequent occasion.

         8.   COMPENSATION.

         (a)  Mitchell Hutchins shall not receive any compensation from the
Series other than reimbursement for the Series' Direct Expenses, as provided in
paragraph 7.

         (b)  For the services provided and the expenses assumed pursuant to
this Contract with respect to any Series as to which this Contract hereafter is
made applicable, the Trust will pay to Mitchell Hutchins from the assets of such
Series compensation in an amount to be agreed upon in a written fee agreement
("Fee Agreement") executed by the Trust on behalf of such Series and by Mitchell
Hutchins. All such Fee Agreements shall provide that they are subject to all
terms and conditions of this Contract.

         (c)  Any compensation or reimbursement due to Mitchell Hutchins shall
be computed daily and paid monthly to Mitchell Hutchins on or before the first
business day of the next succeeding calendar month.

         (d)  If this Contract becomes effective or terminates before the end of
any month, Mitchell Hutchins' compensation or reimbursement for the period from
the effective day to the end of the month or from the beginning of such month to
the date of termination, as the case may be, shall be prorated according to the
proportion which such period bears to the full month in which such effectiveness
or termination occurs.

         9.   LIMITATION OF LIABILITY OF MITCHELL HUTCHINS. Mitchell Hutchins
and its delegates, including any Sub-Adviser or Sub-Administrator to any Series
or the Trust, shall not be liable for any error of judgment or mistake of law or
for any loss suffered by any Series, the Trust or any of its shareholders, in
connection with the matters to which this Contract relates, except to the extent
that such a loss results from willful misfeasance, bad faith or gross negligence
on its part in the performance of its duties or from reckless disregard by it of
its obligations and duties under this Contract. Any person, even though also an
officer, director, employee, or agent of Mitchell

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Hutchins, who may be or become an officer, Trustee, employee or agent of the
Trust shall be deemed, when rendering services to any Series or the Trust or
acting with respect to any business of such Series or the Trust, to be rendering
such service to or acting solely for the Series or the Trust and not as an
officer, director, employee, or agent or one under the control or direction of
Mitchell Hutchins even though paid by it.

         10.  DURATION AND TERMINATION.

         (a)  This Contract shall become effective upon the date hereabove
written provided that, with respect to any Series, this Contract shall not take
effect unless it has first been approved (i) by a vote of a majority of those
Trustees of the Trust who are not parties to this Contract or interested persons
of any such party cast in person at a meeting called for the purpose of voting
on such approval, and (ii) by vote of a majority of that Series' outstanding
voting securities.

         (b)  Unless sooner terminated as provided herein, this Contract shall
continue in effect for two years from the above written date. Thereafter, if not
terminated, this Contract shall continue automatically for successive periods of
twelve months each, provided that such continuance is specifically approved at
least annually (i) by a vote of a majority of those Trustees of the Trust who
are not parties to this Contract or interested persons of any such party, cast
in person at a meeting called for the purpose of voting on such approval, and
(ii) by the Board or, with respect to any given Series, by vote of a majority of
the outstanding voting securities of such Series.

         (c)  Notwithstanding the foregoing, with respect to any Series this
Contract may be terminated at any time, without the payment of any penalty, by
vote of the board or by a vote of a majority of the outstanding voting
securities of such Series on sixty days' written notice to Mitchell Hutchins or
by Mitchell Hutchins at any time, without the payment of any penalty, on sixty
days' written notice to the Trust. Termination of this Contract with respect to
any given Series shall in no way affect the continued validity of this Contract
or the performance thereunder with respect to any other Series. This Contract
will automatically terminate in the event of its assignment.

         11.  LIMITATION OF LIABILITY OF THE TRUSTEES AND SHAREHOLDERS OF THE
TRUST. The Trustees of the Trust and the shareholders of any Series shall not be
liable for any obligations of any Series or the Trust under this Contract, and
Mitchell Hutchins agrees that, in asserting any rights or claims under this
Contract, it shall look only to the assets and property of the Trust in
settlement of such right or claim, and not to such Trustees or shareholders.

         12.  AMENDMENT OF THIS CONTRACT. No provision of this Contract may be
changed, waived, discharged or terminated orally, but only by an instrument in
writing signed by the party against which enforcement of the change, waiver,
discharge or termination is sought, and no amendment of this Contract as to any
given Series shall be effective until approved by vote of a majority of such
Series' outstanding voting securities.

         13.  GOVERNING LAW. This Contract shall be construed in accordance with
the laws of the State of Delaware, without giving effect to the conflicts of
laws principles thereof, and in accordance with the 1940 Act. To the extent that
the applicable laws of the State of Delaware conflict with the applicable
provisions of the 1940 Act, the latter shall control.

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         14.  MISCELLANEOUS. The captions in this Contract are included for
convenience of reference only and in no way define or delimit any of the
provisions hereof or otherwise affect their construction or effect. If any
provision of this Contract shall be held or made invalid by a court decision,
statute, rule or otherwise, the remainder of this Contract shall not be affected
thereby. This Contract shall be binding upon and shall inure to the benefit of
the parties hereto and their respective successors. As used in this Contract,
the terms "majority of the outstanding voting securities", "affiliated person",
"interested person", "assignment", "broker", "investment adviser", "national
securities exchange", "net assets", "prospectus", "sale", "sell" and "security"
shall have the same meaning as such terms have in the 1940 Act and the rules and
regulations thereunder, subject to such exemptions as may be granted by the
Securities and Exchange Commission. Where the effect of a requirement of the
1940 Act reflected in any provision of this Contract is relaxed by a rule,
regulation, order or other action of the Securities and Exchange Commission,
whether of special or general application, such provision shall be deemed to
incorporate the effect of such rule, regulation, order or other action.

         IN WITNESS WHEREOF, the parties hereto have caused this instrument to
be executed by their officers and delivered as of the day and year first above
written.

Attest:                            MITCHELL HUTCHINS ASSET MANAGEMENT INC.

/s/ Andrew S. Novak                By:  /s/ Keith A. Weller
--------------------                    ------------------------------------
Name:  Andrew S. Novak                  Name:  Keith A. Weller
Title:  Vice President                  Title:  First Vice President

Attest:                            MITCHELL HUTCHINS LIR MONEY SERIES

/s/ Cristina Paradiso              By:  /s/ Dianne E. O'Donnell
----------------------                  ------------------------------------
Name:  Cristina Paradiso                Name:  Dianne E. O'Donnell
Title:  Vice President                  Title:  Secretary and Vice President

                                     - 7 -Prepared by MERRILL CORPORATION www.edgaradvantage.com

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EXHIBIT 4.1  

  STOCK PURCHASE AGREEMENT         

    THIS STOCK PURCHASE AGREEMENT (this "Agreement") is made as of            , 2000
between Bioject Medical Technologies, Inc., an Oregon corporation (the "Company"), and                  
      (the
"Investor"). 

    1.  Authorization of Shares.  The Company has duly authorized the sale and issuance of
                        (            ) shares (the "Shares") of common stock of the Company, without par value (the
"Common Stock"), to Investor. The number of Shares equals the quotient of (a) the Purchase Price (as defined below) divided by (b) the
closing sale price of the Common Stock on The Nasdaq Stock Market, Inc. Small Cap Market (the "Nasdaq Small Cap Market") on
            , 2000. 

    2.  Agreement to Sell and Purchase Shares.  Upon the terms and subject to the conditions contained
herein, the Company and the Investor agree that the Investor will purchase from the Company and the Company will issue and sell to the Investor the Shares, for an aggregate purchase price (the
"Purchase Price") of                        ($      
      ). Unless otherwise requested by the Investor, certificates representing the Shares
purchased by the Investor will be registered in the Investor's name and address as set forth on the signature page hereto. 

    3.  Delivery of the Shares at Closing.  The completion of the purchase and sale of the Shares (the
"Closing") shall occur on            , 2000 (the "Closing Date"), at the
office of the Company's transfer agent, American Stock and Transfer Company (the "Escrow Agent"), or at such different time or day or location as the
Company and the Investor mutually agree. At the Closing, the Company shall deliver to the Investor one or more stock certificates representing the Shares, each such certificate to be registered in the
name of the Investor. 

    3.1  The Company's obligation to issue the Shares to the Investor shall be subject to the following conditions, any one
or more of which may be waived by the Company in writing: 

    (a) receipt
by the Company or the Escrow Agent of a wire transfer of funds in the full amount of the Purchase Price; and 

    (b) the
representations and warranties of the Investor set forth herein shall be true and correct in all respects. 

    3.2  The Investor's obligation to purchase the Shares shall be subject to the following conditions, any one or more of
which may be waived by the Investor in writing: 

    (a) the
representations and warranties of the Company set forth herein shall be true and correct in all respects; 

    (b) the
Company shall have performed and complied with all agreements and conditions required by this Agreement to be performed or complied with by it on or before the
Closing Date; 

    (c) the
Company shall have delivered to Investor or the Escrow Agent a certificate dated the Closing Date, executed by the Chief Executive Officer of the Company,
certifying the satisfaction of the conditions specified in subsections (a) and (b) of this Section 3.2; 

    (d) the
Investor or the Escrow Agent shall have received from Stoel Rives LLP, counsel for the Company, a legal opinion dated the Closing Date in the form of  Exhibit A hereto; 

    (e) all
registrations, qualifications, permits and approvals required under applicable state securities laws shall have been obtained for the lawful execution, delivery
and performance of this Agreement, including without limitation the offer, sale, issue and delivery of the Shares; 

    (f)  Investor or the Escrow Agent shall have received the following: 

    (1) Copies
of resolutions of the Company's Board of Directors, certified by the Secretary of the Company, authorizing and approving the execution, delivery and
performance of this Agreement, and all other documents and instruments to be delivered pursuant hereto and thereto; 

    (2) A
certificate of incumbency executed by the Secretary of the Company certifying the names, titles and signatures of the officers authorized to execute the documents
referred to in subsection (1) above and further certifying that the Amended and Restated Articles of Incorporation and Amended and Restated Bylaws of the Company delivered to the Investor at
the time of the execution of this Agreement have been validly adopted, are in full force and effect, and have not been further amended or modified; and 

    (3) Such
additional supporting documentation and other information with respect to the transactions contemplated hereby as Investor may reasonably request; 

    (g) all
corporate and other proceedings and actions taken in connection with the transactions contemplated hereby and all certificates, opinions, agreements,
instruments and documents mentioned herein or incident to any such transactions, shall be satisfactory in form and substance to Investor; 

    (h) Any
approval, consent or waiting period required by any governmental agency or authority, or any other individual, partnership, joint venture, corporation, limited
liability company, trust, estate, unincorporated organization, or any other entity (each, a "Person"), necessary or material to the consummation of the
transactions contemplated hereby shall have been obtained; and 

    (i)  No
order of any court of administrative agency shall be in effect which restrains or prohibits any transaction contemplated hereby which would limit or affect the
Investor's rights hereunder or thereunder. 

    4.  Representations, Warranties and Covenants of the Company.  The Company hereby represents and warrants
to, and covenants with, the Investor, as follows: 

    4.1  Organization.  The Company is duly organized and validly existing under the laws of the State of
Oregon. Each of the Company and its Subsidiaries (as defined in Rule 405 under the Securities Act of 1933, as amended (the "Securities Act")) has
full power and authority to own, operate and occupy its
properties and to conduct its business as presently conducted and as proposed to be conducted and is registered or qualified to do business and in good standing in each jurisdiction in which it owns
or leases property or transacts business and where the failure to be so qualified would have a material adverse effect upon the business, properties, condition (financial or otherwise), operations or
prospects of the Company and its Subsidiaries, considered as one enterprise (collectively, a "Material Adverse Effect"), and no proceeding has been
instituted in any such jurisdiction, revoking, limiting or curtailing, or seeking to revoke, limit or curtail, such power and authority or qualification. All Subsidiaries of the Company are disclosed
in Schedule 4.1. 

    4.2  Due Authorization.  The Company has all requisite power and authority to execute, deliver and
perform its obligations under this Agreement, and this Agreement has been duly authorized and validly executed and delivered by the Company and constitutes the legal, valid and binding agreement of
the Company enforceable against the Company in accordance with its terms. All corporate acts and proceedings required for the authorization, execution and delivery of this Agreement, the offer,
issuance and delivery of the Shares and the performance of this Agreement have been lawfully and validly taken or will have been so taken prior to the Closing. 

2

    4.3  Non-Contravention.  The execution and delivery of this Agreement, the issuance and sale
of the Shares, the fulfillment of the terms of this Agreement and the consummation of the transactions contemplated hereby will not (A) conflict with or constitute a violation of, or default
(with the passage of time or otherwise) under, (i) any material bond, debenture, note or other evidence of indebtedness, or under any material lease, contract, indenture, mortgage, deed of
trust, security agreement, loan or credit agreement, joint venture or other agreement, instrument, commitment or arrangement to which the Company or any Subsidiary is a party or by which the Company
or any of its Subsidiaries or their respective properties are bound, (ii) the Amended and Restated Articles of Incorporation, Amended and Restated Bylaws or other organizational documents of
the Company or any Subsidiary, or (iii) any law, administrative regulation, ordinance or order of any court or governmental agency, arbitration panel or authority applicable to the Company or
any Subsidiary or their respective properties, or (B) result in the creation or imposition of any lien, encumbrance, claim, security interest, charge, option, pledge or restriction whatsoever
(a "Lien") upon any of the material properties, assets or rights of the Company or any Subsidiary or an acceleration of indebtedness pursuant to any
obligation, agreement or condition contained in any material bond, debenture, note or any other evidence of indebtedness or any material, lease, contract, indenture, mortgage, deed of trust, security
agreement, loan or credit agreement or any other agreement or instrument to which the Company or any Subsidiary is a party or by which any of them is bound or to which any of the property or assets of
the Company or any Subsidiary is subject, the result of which would have a Material Adverse Effect. No consent, approval, authorization or other order of, or registration, qualification or filing
with, any regulatory body, administrative agency, or other governmental body in the United States is required for the execution and delivery of this Agreement and the valid issuance and sale of the
Shares to be sold pursuant to the Agreement, other than such as have been made or obtained, and except for any securities filings
required to be made under federal or state securities laws. The execution, delivery and performance by the Company of this Agreement will not require from the Board of Directors or the stockholders of
the Company any consent or approval that has not been validly and lawfully obtained. The Company is not subject to any restriction of any kind or character which prohibits the Company from entering
into this Agreement or would prevent its performance of or compliance with all or any part of this Agreement or the consummation of the transactions contemplated hereby or thereby. 

    4.4  Capitalization.  The capitalization of the Company consists of 100,000,000 shares of Common
Stock, and 10,000,000 shares of preferred stock of the Company, without par value (the "Preferred Stock"), of which 1,235,000 shares have
been designated as Series A Preferred Stock, 200,000 shares have been designated as Series B Preferred Stock, and 500,000 shares have been designated as Series C
Preferred Stock, and the Company has no authority to issue any other capital stock. As of June 30, 2000 6,384,874 shares of Common Stock were issued and outstanding,
692,694 shares of Series A Preferred Stock were issued and outstanding, zero shares of Series B Preferred Stock were issued and outstanding, and 391,830 shares of
Series C Preferred Stock were issued and outstanding. The Shares have been duly authorized, and when issued and paid for in accordance with the terms of the Agreement will be duly and validly
issued, fully paid and nonassessable, free and clear of all Liens and any other restrictions, and were not issued in violation of any preemptive rights or similar rights to subscribe for or purchase
securities. The outstanding shares of capital stock of the Company have been duly authorized and validly issued and are fully paid and nonassessable. Except as disclosed in  Schedule 4.4, no
preemptive right, co-sale right, right of first refusal, registration right, or other similar right exists with
respect to the Shares or the issuance and sale thereof. No further approval or authorization of any stockholder, the Board of Directors of the Company or others is required for the issuance and sale
of the Shares. Except as disclosed in Schedule 4.4, there are no stockholders agreements, voting agreements or other similar agreements with
respect to the capital stock of the Company to which the Company is a party or, to the knowledge of the Company, between or among any of the Company's stockholders. 

3

    4.5  Legal Proceedings.  There is no material legal or governmental proceeding pending or, to the
knowledge of the Company, threatened to which the Company or any Subsidiary or any officer, director or key employee thereof is or may be a party or to which the business or property of the Company or
any Subsidiary is subject. After reasonable investigation, the Company is not aware of any fact which might result in or form the basis for any such action, suit, arbitration, investigation, inquiry
or other proceeding, which if adversely determined would have a Material Adverse Effect. The Company is not in default with respect to any order, writ, judgment, injunction, decree, determination or
award of any court or of any governmental agency or instrumentality (whether federal, state, local or foreign). 

    4.6  No Violations.  Neither the Company nor any Subsidiary is in violation of its charter, bylaws, or
other organizational document, or in violation of any law, administrative regulation, ordinance or order of any court or governmental agency, arbitration panel or authority applicable to the Company
or any Subsidiary, which violation, individually or in the aggregate, would be reasonably likely to have a Material Adverse Effect, or is in default (and there exists no condition which, with the
passage of time or otherwise, would constitute a default) in any material respect in the performance of any bond, debenture, note or any other evidence of indebtedness in any indenture, mortgage, deed
of trust or any other material agreement or instrument to which the Company or any Subsidiary is a party or by which the Company or any Subsidiary is bound or by which the properties of the Company or
any Subsidiary are bound, which would be reasonably likely to have a Material Adverse Effect. To the best of its knowledge, the Company, its Subsidiaries, and their respective businesses, properties
and assets are in compliance in all material respects with all applicable laws and regulations, including without limitation those relating to (a) health, safety and employee relations,
(b) environmental matters, including the discharge of any hazardous or potentially hazardous materials into the environment, and (c) the development, commercialization and sale of
medical devices, pharmaceutical and biotechnology products, including all applicable regulations of the United States Food and Drug Administration and comparable foreign regulatory authorities. 

    4.7  Governmental Permits, Etc.  With the exception of the matters that are dealt with separately under
Sections 4.1, 4.14, 4.15 and 4.16, each of the Company and its Subsidiaries has all necessary franchises, licenses, certificates and other authorizations from any foreign, federal, state or
local government or governmental agency, department, or body that are currently necessary for the operation of the business of the Company and its Subsidiaries as currently conducted, except where the
failure to currently possess could not reasonably be expected to have a Material Adverse Effect. 

    4.8  Intellectual Property.  (i) Each of the Company and its Subsidiaries owns or possesses
sufficient rights to use all patents, patent rights (including patent applications), trademarks, copyrights, licenses, inventions, trade secrets, trade names and know-how (collectively,
"Intellectual Property") that are necessary for the conduct of its business as now conducted or as proposed to be conducted, in each case free and clear
of any right, Lien or claim of others, except where the failure to currently own or possess would not have a Material Adverse Effect, and none of the Company's or any Subsidiary's rights in or use of
such Intellectual Property has been or is currently threatened to be challenged; (ii) neither the Company nor any of its Subsidiaries has received any notice of, or has any knowledge of, any
infringement of asserted rights of a third party with respect to any Intellectual Property that, individually or in the aggregate, would have a Material Adverse Effect; and (iii) neither the
Company nor any of its Subsidiaries has received any notice of any infringement of rights of a third party with respect to any Intellectual Property that, individually or in the aggregate, would have
a Material Adverse Effect. 

    4.9  Financial Statements.  Included in the Company's Annual Report on Form 10-K for
the fiscal year ended March 31, 2000 (the "10-K") are the Company's audited balance sheet (the "Balance
Sheet") as of
March 31, 2000 (the "Balance Sheet Date"), and the audited statement of operations for the fiscal year then ended, together with the related
opinion thereon of Arthur Andersen LLP, 

4

independent certified public accountants. The foregoing financial statements of the Company and the related notes present fairly, in accordance with generally accepted accounting principles
consistently applied, the financial position of the Company and its Subsidiaries as of the dates indicated, and the results of its operations and cash flows for the periods therein specified. Such
financial statements (including the related notes) are in accordance with the books and records of the Company and have been prepared in accordance with generally accepted accounting principles
applied on a consistent basis throughout the periods therein specified. 

    4.10  Taxes.  For purposes of this Agreement, the term
"Taxes" shall include all federal, territorial, state, foreign, municipal and local income, profits, gross receipts, franchise, sales, use, value added,
occupation, property, excise, customs, withholding, unemployment, worker's compensation, social security and other taxes, duties, fees and assessments (including interest and penalties). As of the
date of this Agreement, the Company and each of its Subsidiaries has timely filed or caused to be timely filed all declarations, reports and returns (collectively,
"Returns") for Taxes required by law to be filed and all such returns for Taxes are complete and accurate. The Company has paid, caused to be paid, or
reserved against all Taxes which are shown as due and payable on the Returns. There are no claims pending or, to the best knowledge of the Company, threatened against the Company or any Subsidiary,
for past due Taxes. 

    4.11  Benefit Plans.  Except as disclosed in  Schedule 4.11, which sets forth a true and accurate list and description of any such plans maintained
or sponsored by the Company or to which the
Company is required to make contributions, the Company does not maintain, sponsor, is not required to make contributions to or otherwise have any liability with respect to any pension, profit sharing,
thrift or other retirement plan, employee stock ownership plan, deferred compensation, stock ownership, stock purchase, performance share, bonus or other incentive plan, health or group insurance
plan, welfare plan, or other similar plan, agreement, policy or understanding (whether written or oral), whether or not such plan is intended to be qualified under Section 401(a) of the Code,
within the meaning of Section 3(3) of the Employee Retirement Income Security Act of 1974, as amended, which plan covers any employee or former employee of the Company (collectively,
"Employee Benefit Plans"). To the best knowledge of the Company, all such Employee Benefit Plans are in compliance with applicable law. 

    4.12  Insurance.  The Company has and maintains adequate and sufficient insurance, including liability,
casualty and products liability insurance, covering risks associated with its business, properties and assets, including insurance that is customary for companies similarly situated. 

    4.13  No Material Adverse Change.  Except as disclosed in  Schedule 4.13, since the Balance Sheet Date, there has not been: (a) a material
adverse change in the business, properties, condition
(financial or otherwise), operations or prospects of the Company or any Subsidiary; (b) any damage, destruction or loss, whether or not covered by insurance, materially and adversely affecting
the business, properties, condition (financial or otherwise), operations or prospects of the Company or any Subsidiary; (c) any declaration, setting aside or payment of any dividend or any
distribution or payment (whether in cash, stock or property) in respect of the capital stock of the Company or any Subsidiary, or any redemption or other acquisition of such stock by the Company or
any Subsidiary; (d) any waiver by the Company or any Subsidiary of a valuable right or of a material debt owed to it; (e) any debt, obligation or liability incurred, assumed or
guaranteed by the Company or any Subsidiary, except in the ordinary course of business; (f) any change in any material agreement to which the Company or any Subsidiary is a party or by which it
is bound which has or, so far as the Company may now foresee, in the future may have a Material Adverse Effect; or (g) any change in the assets, liabilities, condition (financial or otherwise),
results or operations or prospects of the Company or any Subsidiary from those reflected on the 10-K, except changes in the ordinary course of business that have not, individually or in
the aggregate, had a Material Adverse Effect. 

5

    4.14  SEC and NASDAQ Compliance.  The Company's Common Stock is registered pursuant to
Section 12(g) of the Securities Exchange Act of 1934, as amended (the "Exchange Act"), and is listed on The Nasdaq Small Cap Market, and the
Company has taken no action designed to, or likely to have the effect of, terminating the registration of the Common Stock under the Exchange Act or de-listing the Common Stock from the
Nasdaq Small Cap Market, nor, except as disclosed on Schedule 4.14, has the Company received any notification that the Securities and Exchange
Commission (the "SEC") or the National Association of Securities Dealers, Inc. ("NASD") is
contemplating terminating such registration or listing. 

    4.15  Reporting Status.  The Company has filed in a timely manner all documents that the Company was
required to file under the Exchange Act during the twelve (12) months preceding the date of this Agreement. The following documents complied in all material respects with the SEC's requirements
as of their respective filing dates, and the information contained therein as of the date thereof did not contain an untrue statement of a material fact or omit to state a material fact required to be
stated therein or necessary to make the statements therein in light of the circumstances under where they were made not misleading: 

    (a) the
10-K; and 

    (b) all
other documents, if any, filed by the Company with the SEC since March 31, 2000 pursuant to the reporting requirements of the Exchange Act. 

    4.16  Listing.  The Company shall comply with all requirements of the NASD with respect to the issuance
of the Shares and the listing thereof on the Nasdaq Small Cap Market. 

    4.17  No Manipulation of Stock.  The Company has not taken and will not, in violation of applicable law,
take, any action designed to or that might reasonably be expected to cause or result in stabilization or manipulation of the price of the Common Stock to facilitate the sale or resale of the Shares. 

    4.18  Registration Rights.  Other than under this Agreement and as disclosed on  Schedule 4.4, the Company has not agreed to register under the
Securities Act any of its authorized or outstanding securities. The registration
rights disclosed on Schedule 4.4 do not conflict with the registration rights granted under this Agreement. 

    4.19  No Brokers or Finders.  Except for H.C. Wainwright & Co., Inc., no Person has,
or as a result of the transactions contemplated herein will have, any right or valid claim against the Company or the Investor for any commission, fee or other compensation as a finder or broker, or
in any similar capacity based upon obligations incurred by the Company. 

    4.20  Disclosure.  The information contained in this Agreement, in the 10-K, and in any
writing furnished pursuant hereto or in connection herewith, taken as a whole, is true, complete and correct, and does not contain any untrue statement of a material fact or omit to state any material
fact required to be stated therein or herein or necessary to make the statements therein or herein, in light of the circumstances under which they were made, not misleading. 

    5.  Representations, Warranties and Covenants of the Investor.  

    5.1  Accredited Investor.  The Investor represents and warrants to, and covenants with, the Company that:
(i) the Investor is an "accredited investor" as defined in Regulation D under the Securities Act and the Investor is also knowledgeable, sophisticated and experienced in making, and is
qualified to make
decisions with respect to investments in shares presenting an investment decision like that involved in the purchase of the Shares; (ii) the Investor is acquiring the Shares in the ordinary
course of its business and for its own account for investment only and with no present intention of distributing any of such Shares or any arrangement or understanding with any other persons regarding
the distribution of such Shares; (iii) the Investor will not, directly or indirectly, offer, sell, pledge, 

6

transfer or otherwise dispose of (or solicit any offers to buy, purchase or otherwise acquire or take a pledge of) any of the Shares except in compliance with the Securities Act, applicable state
securities laws and the respective rules and regulations promulgated thereunder; and (iv) the Investor will notify the Company promptly of any change in any of such information until such time
as the Investor has sold all of its Shares or until the Company is no longer required to keep the Registration Statement (as defined in Section 7.1) effective. Nothing contained in this
Section 5.1 shall limit any of the Company's representations or warranties or limit the Investor's recourse in respect thereof. 

    5.2  Compliance with Prospectus Delivery Requirement.  The Investor hereby covenants with the Company not
to make any sale of the Shares without complying with the provisions of this Agreement, including Section 7.2 hereof, and without effectively causing the prospectus delivery requirement under
the Securities Act to be satisfied, and the Investor acknowledges that the certificates evidencing the Shares will be imprinted with a legend that prohibits their transfer except in accordance
therewith. The Investor acknowledges that there may occasionally be times when the Company determines that it must suspend the use of the Prospectus forming a part of the Registration Statement, as
set forth in Section 7.2(c). 

    5.3  Due Authorization.  The Investor has all requisite power and authority to execute, deliver and
perform its obligations under this Agreement, and this Agreement has been duly authorized and validly executed and delivered by the Investor and constitutes the legal, valid and binding agreement of
the Investor enforceable against the Investor in accordance with its terms. All corporate acts and proceedings required for the authorization, execution and delivery of this Agreement and the
performance of this Agreement have been lawfully and validly taken or will have been so taken prior to the Closing. 

    5.4  No Brokers or Finders.  Except for H.C. Wainwright & Co., Inc., no Person has,
or as a result of the transactions contemplated herein will have, any right or valid claim against the Company or the Investor for any commission, fee or other compensation as a finder or broker, or
in any similar capacity based upon obligations incurred by the Investor. 

    6.  Enforcement.  

    6.1  Survival of Representations, Warranties, Covenants and Agreements.  Notwithstanding any
investigation made by any party to this Agreement, all covenants, agreements, representations and warranties made by the Company and the Investor herein shall survive the execution of this Agreement,
the delivery to the Investor of the Shares being purchased and the payment therefor. 

    6.2  Indemnification.  

    (a) The
Company hereby covenants and agrees to defend, indemnify and save and hold harmless the Investor, together with its officers, directors, shareholders,
employees, attorneys and representatives and each Person who controls, is controlled by or is under common control with Investor within the meaning of the Securities Act, from and against any loss,
cost, expense, liability, claim or legal damages (including, without limitation, reasonable fees and disbursements of counsel and accountants and other costs and expenses incident to any actual or
threatened claim, suit, action or proceeding, and all costs of investigation) (collectively, the "Damages") arising out of or resulting from
(i) any inaccuracy in or breach of, or failure to perform or observe, any representation, warranty, covenant or agreement made by the Company in this Agreement or in any writing delivered
pursuant to this Agreement or at the Closing, or (ii) any claims of third parties claiming compensation, commissions or expenses for services as a broker or finder based upon obligations
incurred by the Company. Damages resulting directly from the gross negligence or willful misconduct of Investor or any of its respective officers, directors, employees or any Person who controls, is
controlled by or is under common control with Investor within the meaning of the Securities Act are not covered under this Section 6.2(a). 

7

    (b) Investor hereby covenants and agrees to defend, indemnify and save and hold harmless the Company, together with its officers, directors, shareholders, employees,
attorneys and representatives and each Person who controls, is controlled by or is under common control with the Company within the meaning of the Securities Act, from and against any Damages arising
out of or resulting from (i) any inaccuracy in or breach of, or failure to perform or observe, any representation, warranty, covenant or agreement made by the Investor in this Agreement or in
any writing or other agreement delivered pursuant hereto, or (ii) any claims of third parties claiming compensation, commissions or expenses for services as a broker or finder based upon
obligations incurred by the Investor. Damages resulting directly from the gross negligence or willful misconduct of the Company or any of its respective officers, directors, employees or any Person
who controls, is controlled by or is under common control with the Company within the meaning of the Securities Act are not covered under this Section 6.2(b). 

    (c) Each
party entitled to be indemnified pursuant to Section 6.2(a) or 6.2(b) (each, an "Indemnified Party")
shall notify the other party (the "Indemnifying Party") in writing of any action against such Indemnified Party in respect of which the Indemnifying
Party is or may be obligated to provide indemnification on account of Section 6.2(a) or 6.2(b), promptly after the receipt of notice or knowledge of the commencement thereof. The omission of
any Indemnified Party so to notify the Indemnifying Party of any such action shall not relieve the Indemnifying Party from any liability which it may have to such Indemnified Party except to the
extent the Indemnifying Party shall have been materially prejudiced by the omission of such Indemnified Party so to notify it, pursuant to this Section 6.2(c). In case any such action shall be
brought against any Indemnified Party and it shall notify the Indemnifying Party of the commencement thereof, the Indemnifying Party shall be entitled to assume the defense thereof, with counsel
reasonably satisfactory to such Indemnified Party, and after notice from it to such Indemnified Party of its election so to assume the defense thereof, the Indemnifying Party will not be liable to
such Indemnified Party under Section 6.2(a) or 6.2(b) for any legal or other expense subsequently incurred by such Indemnified Party in connection with the defense thereof nor for any
settlement thereof entered into without the consent of the Indemnifying Party; provided, however, that
(i) if the Indemnifying Party shall elect not to assume the defense of such claim or action or (ii) if the Indemnified Party reasonably determines (x) that there may be a conflict
between the positions of the Indemnifying Party and of the Indemnified Party in defending such claim or action or (y) that there may be legal defenses available to such Indemnified Party
different from or in addition to those available to the Indemnifying Party, then separate counsel for the Indemnified Party shall be entitled to participate in and conduct the defense, in the case of
(i) and (ii)(x), or such different defenses, in the case of (ii)(y), and the Indemnifying Party shall be liable for any reasonable legal or other expenses incurred by the Indemnified Party in
connection with the defense. 

    (d) Neither
the Indemnified Party nor the Indemnifying Party may concede, settle or compromise any action contemplated by Section 6.2(c) without the consent of
the other party, which consent will not be unreasonably withheld or delayed in light of all factors of importance to such party; provided,  however, that if
the Indemnified Party shall fail to consent to the settlement of any action where (i) such settlement includes an unconditional
release of all actions against the Indemnified Party and requires no payment on the part of the Indemnified Party to the claimant or any other party, (ii) such settlement does not require any
action on the part of the Indemnified Party and does not impose terms restricting or adversely affecting the Indemnified Party's activity, and (iii) the claimant has affirmatively indicated
that it will accept such settlement, then the Indemnifying Party shall have no liability with respect to any payment to be made in respect of such action in excess of the proposed settlement amount. 

8

    (e) The foregoing indemnification provisions are in addition to, and not in derogation of, any statutory, equitable or common-law remedy any party may have
for breach of representation, warranty, covenant or agreement, or otherwise. 

    6.3  Injunctive Relief.  (a) Any party may bring a claim seeking specific performance by way of
injunctive relief before a court of competent jurisdiction in accordance with Section 9.3 to enforce the provisions of this Agreement, and (b) in the event of any breach by either party
of Section 9.10, the other party may seek injunctive relief from a court of competent jurisdiction to restrain any such breach. 

    6.4  No Implied Waiver.  Except as expressly provided in this Agreement, no course of dealing between the
Company and Investor and no delay in exercising any such right, power or remedy conferred hereby or now or hereafter existing at law in equity, by statute or otherwise, shall operate as a waiver of,
or otherwise prejudice, any such right, power or remedy. 

    7.  Registration of the Shares; Compliance with the Securities Act.  

    7.1  Registration Procedures and Expenses.  The Company shall: 

    (a) use
its efforts to prepare and file with the SEC, within thirty (30) days after the Closing Date and after giving Investor's legal counsel reasonable time to
review and comment, a registration statement (the "Registration Statement") to enable the resale of the Shares by the Investor from time to time through
the automated quotation system of the Nasdaq Small Cap Market or in privately-negotiated transactions; 

    (b) use
its best efforts to cause the Registration Statement to become effective within ninety (90) days after the Registration Statement is filed by the
Company; 

    (c) use
its best efforts to prepare and file with the SEC such amendments and supplements to the Registration Statement and any prospectus used in connection therewith
(a "Prospectus") as may be necessary to keep the Registration Statement current and effective for a period not exceeding, with respect to the Shares,
the earlier of (i) the date on which the Investor may sell all Shares then held by the Investor without restriction by the volume limitations of Rule 144(e) of the Securities Act, or
(ii) such time as none of the Shares are held by the Investor or a permitted assignee pursuant to Section 9.2; 

    (d) furnish
to the Investor with respect to the Shares registered under the Registration Statement such number of copies of the Registration Statement, Prospectuses and
Preliminary Prospectuses in conformity with the requirements of the Securities Act and such other documents as the Investor may reasonably request, in order to facilitate the public sale or other
Disposition of all or any of the Shares by the Investor; 

    (e) file
documents required of the Company for blue sky clearance in states specified in writing by the Investor;  provided, however, that the Company shall not be
required to qualify to do business or consent to
service of process in any jurisdiction in which it is not now so qualified or has not so consented; 

    (f)  bear
all expenses in connection with the procedures in paragraph (a) through (e) of this Section 7.1 and the registration of the Shares
pursuant to the Registration Statement; and 

    (g) advise
the Investor, promptly after it shall receive notice or obtain knowledge of the issuance of any stop order by the SEC delaying or suspending the
effectiveness of the Registration Statement or of the initiation or threat of any proceeding for that purpose; and it will promptly use its best efforts to prevent the issuance of any stop order or to
obtain its withdrawal at the earliest possible moment if such stop order should be issued. 

9

    The
Company understands that the Investor disclaims being an underwriter, but the Investor being deemed an underwriter by the SEC shall not relieve the Company of any obligations it
has hereunder; provided, however that if the Company receives notification from the SEC that the
Investor is deemed an underwriter, then the ninety day period provided in Section 7.1(b) shall be extended to the earlier of (i) the ninetieth (90th) day after such SEC
notification, or (ii) one hundred twenty (120) days after the initial filing of the Registration Statement with the SEC. 

    7.2  Transfer of Shares After Registration; Suspension.  

    (a) The
Investor agrees that it will not effect any sale, assignment or other transfer (a "Disposition") of the Shares
or its right to purchase the Shares that would constitute a sale within the meaning of the Securities Act except as contemplated in the Registration Statement referred to in Section 7.1 and as
described below, and that it will promptly notify the Company of any changes in the information set forth in the Registration Statement regarding the Investor or its plan of distribution. 

    (b) Except
in the event that paragraph (c) below applies, the Company shall (i) if deemed necessary by the Investor, prepare and file from time to time
with the SEC a post-effective amendment to the Registration Statement or a supplement to the related Prospectus or a supplement or amendment to any document incorporated therein by
reference or file any other required document (A) so that such Registration Statement will not contain an untrue statement of a material fact or omit to state a material fact required to be
stated therein or necessary to make the statements therein not misleading, and so that, as thereafter delivered to purchasers of the Shares being sold thereunder, such Prospectus will not contain an
untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were
made, not misleading or (B) to revise or amend the plan of distribution of the Shares as requested by Investor; (ii) provide the Investor copies of any documents filed pursuant to
Section 7.2(b)(i); and (iii) inform each Investor that the Company has complied with its obligations in Section 7.2(b)(i) (or that, if the Company has filed a
post-effective amendment to the Registration Statement which has not yet been declared effective, the Company will notify the Investor to that effect, will use its reasonable efforts to
secure the effectiveness of such post-effective amendment as promptly as possible and will promptly notify the Investor pursuant to Section 7.2(b)(i) hereof when the
amendment has become effective). 

    (c) Subject
to paragraph (d) below, in the event (i) of any request by the SEC or any other federal or state governmental authority during the period of
effectiveness of the Registration Statement for
amendments or supplements to a Registration Statement or related Prospectus or for additional information; (ii) of the issuance by the SEC or any other federal or state governmental authority
of any stop order suspending the effectiveness of a Registration Statement or the initiation of any proceedings for that purpose; (iii) of the receipt by the Company of any notification with
respect to the suspension of the qualification or exemption from qualification of any of the Shares for sale in any jurisdiction or the initiation or threatening of any proceeding for such purpose; or
(iv) of any event or circumstance which, upon the advice of its counsel, necessitates the making of any changes in the Registration Statement or Prospectus, or any document incorporated or
deemed to be incorporated therein by reference, so that, in the case of the Registration Statement, it will not contain any untrue statement of a material fact or any omission to state a material fact
required to be stated therein or necessary to make the statements therein not misleading, and that in the case of the Prospectus, it will not contain any untrue statement of a material fact or any
omission to state a material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading; then the
Company shall deliver a certificate in writing to the Investor (the "Suspension Notice") to the effect of the foregoing and, upon receipt of such 

10

Suspension Notice, the Investor will refrain from selling any Shares pursuant to the Registration Statement (a "Suspension") until the Investor's
receipt of copies of a supplemented or amended Prospectus prepared and filed by the Company, or until it is advised in writing by the Company that the current Prospectus may be used, and has received
copies of any additional or supplemental filings that are incorporated or deemed incorporated by reference in any such Prospectus. In the event of any Suspension, the Company will use its best efforts
to cause the use of the Prospectus so suspended to be resumed as soon as reasonably practicable, and in any event not more than thirty (30) days after the delivery of a Suspension Notice to the
Investor; provided, however, that the Company shall not be required to amend a Registration Statement or
supplement a Prospectus for a period of up to ninety (90) days after delivery of a Suspension Notice to the Investor if the Company's Board of Directors determines in good faith that to do so
would be seriously detrimental to any proposed material financing, acquisition or disposition of assets (other than in the ordinary course of business), or any material merger, consolidation, tender
offer or similar material transaction involving the Company, it being understood that the period for which the Company is obligated to keep the Registration Statement effective under
Section 7.1(c) shall be extended for a number of days equal to the number of days the Company delays amendment or supplement pursuant to this provision; provided
that the Company shall be able to delay amendment or supplement pursuant to this provision only once. In addition to and without limiting any other remedies (including, without
limitation, at law or at equity) available to the Investor, the Investor shall be entitled to specific performance in the event that the Company fails to comply with the provisions of this
Section 7.2(c). 

    (d) Provided
that a Suspension is not then in effect the Investor may sell Shares under the Registration Statement, provided that it arranges for delivery of a current
Prospectus to the transferee of such Shares or sells the Shares pursuant to an exemption under the Securities Act. Upon receipt of a request therefor, the Company agrees to provide an adequate number
of current Prospectuses to the Investor and to supply copies to any other parties requiring such Prospectuses. 

    7.3  Indemnification.  For the purpose of this Section 7.3: 

    (i)  the
term "Selling Stockholder" shall include the Investor and any Person controlling, controlled by or under common
control with Investor (an "Affiliate"); 

    (ii) the
term "Registration Statement" shall include any final Prospectus, exhibit, supplement or amendment included in
or relating to the Registration Statement referred to in Section 7.1; and 

    (iii) the
term "untrue statement" shall include any untrue statement or alleged untrue statement, or any omission or
alleged omission to state in the Registration Statement a material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances under which they
were made, not misleading. 

    (a) The
Company agrees to indemnify and hold harmless each Selling Stockholder, together with its officers, directors, shareholders, employees, attorneys and
representatives and each Person who controls, is controlled by or is under common control with the Selling Stockholder within the meaning of the Securities Act, from and against any losses, claims,
damages or liabilities to which such Selling Stockholder may become subject (under the Securities Act or otherwise) insofar as such losses, claims, damages or liabilities (or actions or proceedings in
respect thereof) arise out of, or are based upon (i) any untrue statement of a material fact contained in the Registration Statement, or (ii) any failure by the Company to fulfill any
undertaking included in the Registration Statement, and the Company will reimburse such Selling Stockholder, together with its officers, directors, shareholders, employees, attorneys and
representatives and each Person who controls, is controlled by or is under common control with the Selling Stockholder within the meaning of the Securities Act, for any reasonable legal or 

11

other expenses reasonably incurred in investigating, defending or preparing to defend any such action, proceeding or claim, or preparing to defend any such action, proceeding or claim;  provided,
however, that the Company shall not be liable in any such case to the extent that such loss,
claim, damage or liability arises out of, or is based upon, an untrue statement made in such Registration Statement in reliance upon and in strict conformity with written information furnished to the
Company by or on behalf of such Selling Stockholder specifically for use in preparation of the Registration Statement. 

    (b) The
Investor agrees to indemnify and hold harmless the Company (and each person, if any, who controls the Company within the meaning of Section 15 of the
Securities Act, each officer of the Company who signs the Registration Statement and each director of the Company) from and against any losses, claims, damages or liabilities to which the Company (or
any such officer, director or controlling person) may become subject (under the Securities Act or otherwise), insofar as such losses, claims, damages or liabilities (or actions or proceedings in
respect thereof) arise out of, or are based upon, any untrue statement of a material fact contained in the Registration Statement if such untrue statement was made in reliance upon and in strict
conformity with written information furnished by or on behalf of the Investor specifically for use in preparation of the Registration Statement, and the Investor will reimburse the Company (or such
officer, director or controlling person), as the case may be, for any legal or other expenses reasonably incurred in investigating, defending or preparing to defend any such action, proceeding or
claim; provided that the Investor's obligation to indemnify the Company shall be limited to the net amount received by the Investor from the sale of the
Shares sold by the Investor pursuant to the Registration Statement. 

    (c) Promptly
after receipt by any indemnified person of a notice of a claim or the beginning of any action in respect of which indemnity is to be sought against an
indemnifying person pursuant to this Section 7.3, such indemnified person shall notify the indemnifying person in writing of such claim or of the commencement of such action, but the omission
to so notify the indemnifying party will not relieve it from any liability which it may have to any indemnified party under this Section 7.3 (except to the extent that such omission materially
and adversely affects the indemnifying party's ability to defend such action) or from any liability otherwise than under this Section 7.3. Subject to the provisions hereinafter stated, in case
any such action shall be brought against an indemnified person, the indemnifying person shall be entitled to participate therein, and, to the extent that it shall elect by written notice delivered to
the indemnified party promptly after receiving the aforesaid notice from such indemnified party, shall be entitled to assume the defense thereof, with counsel reasonably satisfactory to such
indemnified person. After notice from the indemnifying person to such indemnified person of its election to assume the defense thereof, such indemnifying person shall not be liable to such indemnified
person for any legal expenses subsequently incurred by such indemnified person in connection with the defense thereof; provided,  however, that if there
exists or shall exist a conflict of interest that would make it inappropriate, in the opinion of counsel to the indemnified
person, for the same counsel to represent both the indemnified person and such indemnifying person or any affiliate or associate thereof, the indemnified person shall be entitled to retain its own
counsel at the expense of such indemnifying person, so long as no indemnifying person is responsible for the fees and expenses of more than one separate counsel for all indemnified parties. In no
event shall any indemnifying person be liable in respect of any amounts paid in settlement of any action unless the indemnifying person shall have approved the terms of such settlement;  provided that
such consent shall not be unreasonably withheld. No indemnifying person shall, without the prior written consent of the indemnified
person, effect any settlement of any pending or threatened proceeding in respect of which any indemnified person is or could have been a party and indemnification could have been sought hereunder by
such indemnified person, unless such settlement includes an unconditional 

12

release of such indemnified person from all liability on claims that are the subject matter of such proceeding. 

    (d) If
the indemnification provided for in this Section 7.3 is unavailable to or insufficient to hold harmless an indemnified party under subsection
(a) or (b) above in respect of any losses, claims, damages or liabilities (or actions or proceedings in respect thereof) referred to therein, then each indemnifying party shall
contribute to the amount paid or payable by such indemnified party as a result of such losses, claims, damages or liabilities (or actions in respect thereof) in such proportion as is appropriate to
reflect the relative fault of the Company on the one hand and the Investor on the other in connection with the statements or omissions or other matters which resulted in such losses, claims, damages
or liabilities (or actions in respect thereof), as well as any other relevant equitable considerations. The relative fault shall be determined by reference to, among other things, in the case of an
untrue statement, whether the untrue statement relates to information supplied by the Company on the one hand or the Investor on the other and the parties' relative intent, knowledge, access to
information and opportunity to correct or prevent such untrue statement. The amount paid or payable by an indemnified party as a result of the losses, claims, damages or liabilities (or actions in
respect thereof) referred to above in this subsection (d) shall be deemed to include any legal or other expenses reasonably incurred by such indemnified party in connection with investigating
or defending any such action or claim. Notwithstanding the provisions of this subsection (d), the Investor shall not be required to contribute any amount in excess of the amount by which the
net amount received by the Investor from the sale of the Shares to which such loss relates exceeds the amount of any damages which the Investor has otherwise been required to pay by reason of such
untrue statement. No person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any person who was not
guilty of such fraudulent misrepresentation. 

    (e) The
parties to this Agreement hereby acknowledge that they are sophisticated business persons who were represented by counsel during the negotiations regarding the
provisions hereof including, without limitation, the provisions of this Section 7.3, and are fully informed regarding said provisions. They further acknowledge that the provisions of this
Section 7.3 fairly allocate the risks in light of the ability of the parties to investigate the Company and its business in order to assure that adequate disclosure is made in the Registration
Statement as required by the Act and the Exchange Act. The parties are advised that federal or state public policy as interpreted by the courts in certain jurisdictions may be contrary to certain of
the provisions of this Section 7.3, and the parties hereto hereby expressly waive and relinquish any right or ability to assert such public policy as a defense to a claim under this
Section 7.3 and further agree not to attempt to assert any such defense. 

    7.4  Termination of Conditions and Obligations.  The conditions precedent imposed by Section 5 or
this Section 7 upon the transferability of the Shares shall cease and terminate as to any particular number of the Shares when such Shares shall have been effectively registered for resale
under the Securities Act and sold or otherwise disposed of in accordance with the intended method of Disposition set forth in the Registration Statement covering such Shares or at such time as an
opinion of counsel satisfactory to
the Company in its reasonable judgment shall have been rendered to the effect that such conditions are not necessary in order to comply with the Securities Act. 

    7.5  Information Available.  So long as the Registration Statement is effective covering the resale of
Shares owned by the Investor, the Company will furnish to the Investor: 

    (a) as
soon as practicable after it is available, one copy of (i) its Annual Report to Stockholders (which Annual Report is mailed to shareholders with the
Company's Form 10-K, 

13

which shall contain financial statements audited in accordance with generally accepted accounting principles by a national firm of certified public accountants), (ii) its Annual Report on
Form 10-K and (iii) its Quarterly Reports on Form 10-Q (the foregoing, in each case, including exhibits); and 

    (b) an
adequate number of copies of the Prospectuses to supply to any other party requiring such Prospectuses; and the Company, upon the reasonable request of the
Investor, will meet with the Investor or a representative thereof at the Company's headquarters to discuss all information relevant for disclosure in the Registration Statement covering the Shares and
will otherwise cooperate with the Investor conducting an investigation for the purpose of reducing or eliminating the Investor's exposure to liability under the Securities Act, including the
reasonable production of information at the Company's headquarters. 

    7.6  Other Registration Rights.  Except as provided in Section 7.4, so long as the Investor or any
of its Affiliates owns any of the Shares, the Company will not grant to any Person the right to request to register any equity securities of the Company, or any securities convertible or exchangeable
into or exercisable for such securities, which right is in conflict with the rights granted to the Investor hereunder, without the prior written consent of the Investor. 

    8.  Notices.  All notices, requests, consents and other communications hereunder shall be in writing,
shall be mailed (a) if within domestic United States by first-class registered or certified airmail, or nationally recognized overnight express courier, postage prepaid, or by facsimile, or
(b) if delivered from outside the United States, by International Federal Express or facsimile, and shall be deemed given (i) if delivered by first-class registered or certified mail
domestic, three business days after so mailed, (ii) if delivered by nationally recognized overnight carrier, one business day after so mailed, (iii) if delivered
by International Federal Express, two business days after so mailed, (iv) if delivered by facsimile, upon electric confirmation of receipt and shall be delivered as addressed as follows: 

    (a) if
to the Company, to: 

Bioject
Medical Technologies, Inc.

7620 S.W. Bridgeport Road

Portland, Oregon 97224

Attn: James O'Shea, Chairman, President

and Chief Executive Officer

Facsimile: (503) 620-6431 

      with
a copy to: 

Stoel
Rives LLP

900 SW Fifth Avenue, Suite 2600

Portland, OR 97204-1268

Attn: Todd A. Bauman

Facsimile: (503) 220-2480 

    (b) if
to the Investor, to: 

14

    9.  Miscellaneous.  

    9.1  No Waiver.  Failure by either party to insist upon strict observance of or compliance with any of
the terms of this Agreement in one or more instances shall not be deemed to be a waiver of its rights to
insist upon such observance of compliance with the other terms hereof nor any waiver with respect to any subsequent failures to observe compliance with such terms in the future. 

    9.2  Assignment.  Neither this Agreement nor any interest herein may be assigned by either party hereto
without the written consent of the other party hereto, except that Investor may assign all of its rights hereunder to any Affiliate of Investor. Subject to the foregoing, all the terms and provisions
of this Agreement shall be binding upon and inure to the benefit of and be enforceable by the respective successors and assigns of the parties hereto, whether so expressed or not. Subject to the
immediately preceding sentence, this Agreement shall not run to the benefit of or be enforceable by any Person other than a party to this Agreement and its successors and assigns. The Company may not
assign this Agreement without the prior written consent of the Investor, which may be withheld in the Investor's sole discretion. This Agreement shall be binding upon and inure to the benefit of the
parties, their successors and permitted assigns. 

    9.3  Governing Law.  This Agreement is governed by the laws of the State of Oregon, without regard to its
principles of conflicts of law. 

    9.4  Further Actions.  The parties agree to execute, acknowledge and deliver such further instruments and
to do all such other incidental acts as may be reasonably necessary or appropriate to carry out the purpose and intent of this Agreement. 

    9.5  Severability.  In the event any one or more of the provisions of this Agreement should for any
reason be held by any court or authority having jurisdiction over either of the parties or this Agreement to be invalid, illegal or unenforceable, such provision or provisions shall be validly
reformed so as to as nearly approximate the intent of the parties as possible or, if unreformable, shall be divisible and deleted in such jurisdiction; elsewhere, this Agreement shall not be affected. 

    9.6  Captions.  The Parties agree that the headings in the Agreement are used for the convenience of the
Parties only and are not intended to be used in the interpretation of this Agreement. 

    9.7  Entire Agreement.  This Agreement, including the Exhibits and other documents provided for herein
and contemplated hereby, contains the entire understanding between the parties hereto in respect of the subject matter contained herein and supersedes all prior agreements, understandings,
representations and communications, whether written or oral. This Agreement shall not be amended or supplemented except in a written document duly executed by a duly authorized representative of each
party. 

    9.8  Counterparts.  This Agreement may be executed in two or more counterparts, each of which shall
constitute an original, but all of which, when taken together, shall constitute but one instrument, and shall become effective when one or more counterparts have been signed by each party hereto and
delivered to the other parties. 

    9.9  Rule 144.  The Company covenants that it will file the reports required to be filed by it
under the Securities Act and the Exchange Act and the rules and regulations adopted by the SEC thereunder (or, if the Company is not required to file such reports, it will, upon the request of the
Investor made after the first anniversary of the Closing Date, make publicly available such information as necessary to permit sales pursuant to Rule 144 under the Securities Act), and it will
take such further action as the Investor may reasonably request, all to the extent required from time to time to enable the Investor to sell Shares purchased hereunder without registration under the
Securities Act within the limitation of the exemptions provided by (a) Rule 144 under the Securities Act, as such Rule may be amended from time to time, or (b) any similar rule or
regulation hereafter adopted by 

15

the SEC. Upon the request of the Investor, the Company will deliver to such holder a written statement as to whether it has complied with such information and requirements. 

    IN
WITNESS WHEREOF, the parties have executed this Agreement as of the date first written above. 

	By:	 	

	 

BIOJECT MEDICAL TECHNOLOGIES, INC.
	 

By:	 
 	 

 James C. O'Shea

President and Chief Executive Officer

16

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