Document:

EX-10.6.1

EXHIBIT 10.6.1

* Certain portions of this exhibit have been omitted pursuant to a request for confidential

treatment which has been filed separately with the SEC.

THIRD AMENDMENT

TO

CONTRACT SALES AND SERVICE AGREEMENT

     This Third Amendment to Contract Sales and Service Agreement (“Third Amendment”) is entered
into as of March 26, 2008, by and between VENTIV COMMERCIAL SERVICES, LLC, a New Jersey limited
liability company d/b/a as Inventiv Commercial, LLC (“Ventiv”) and Cumberland Pharmaceuticals, Inc.
a Tennessee corporation (“Cumberland”).

W I T N E S S E T H

     WHEREAS, Ventiv, as successor in interest to Cardinal Health PTS, LLC, and Cumberland are
parties to that certain Contract Sales and Service Agreement dated as of May 16, 2006, as amended,
by that First Amendment to Contract Sales and Service Agreement dated as of July 19, 2006 and that
Second Amendment to Contract Sales and Service Agreement dated June 1, 2007 (collectively, the
“Service Agreement”); and

     WHEREAS, Ventiv and Cumberland desire to lengthen the period covered by the Service Agreement
and to make certain other adjustments to the terms and conditions of the Service Agreement as set
forth in this Third Amendment; and

     WHEREAS, capitalized terms used herein without definition shall have the respective meanings
ascribed thereto in the Service Agreement.

     NOW, THEREFORE, in consideration of the premises and other good and valuable consideration,
the receipt and adequacy of which are hereby acknowledged, it is agreed as follows:

     1. Section 1 of the First Amendment to Contract Sales and Service Agreement dated July 19,
2006, the description of the Syndicated Sales Force is hereby deleted in its entirety.

     2. Section 2.1 of the Service Agreement shall be amended to provide that Ventiv shall provide
Cumberland with an additional fourteen (14) Representatives (“Additional Representatives”) for a
total of thirty-eight (38) full-time Representatives commencing on or about March 10, 2008 (the
“Hire Date”). The Additional Representatives shall provide the services of the Representatives set
forth in the Service Agreement. In connection with the Product Detail, Ventiv shall provide the
following services:

          (a) Implementation — recruit and train the Additional Representatives, with training
consisting of five (5) days of home study and five (5) days of initial training to commence on
March 17, 2008 (the “Training Date”).

          (b) Deployment — (i) Deployment of the thirty-eight (38) Representatives (base salary,
benefits, handheld PDA’s and laptops (including sales force automation software), printers and
bonus targeted at [***] of base salary), (ii) four (4) Managers (base salary, benefits, laptops
(including sales force automation software), printers, and bonus targeted at [***] of base salary),
and (iii) turnover training and recruiting and (iv) office costs/operational supplies. As set
forth in this Agreement, “Deployment” or “Deployment Date” means the date the Representatives
commence Product Detailing pursuant to the Service

 

 

Agreement. The Representatives will be deployed and commence Product Detailing on or about March
24, 2008 (the “Deployment” or “Deployment Date”).

     3. Section 2.2 of the Service Agreement shall be amended to provide that Ventiv shall provide
Cumberland with an additional two (2) Managers (“Additional Managers”) for a total of four (4)
Managers.

     4. Delete the first sentence of Section 2.3(f) in its entirety.

     5. In Section 2.6 of the Service Agreement, delete all references to “six (6)” and replace
with “four (4)”.

     6. Section 14 of the Service Agreement is amended to provide that the Agreement shall be
extended as of the Effective Date, until April 1, 2010 (the “Renewal Term”).

     7. Schedule 3.1 of the Service Agreement shall be deleted in its entirety and replaced with
the attached Schedule 3.1.

     8. The validity of this Third Amendment, its construction, interpretation and enforcement, the
rights of the parties hereunder, shall be determined under, governed by, and construed in
accordance with the laws of the State of Tennessee.

     9. This Third Amendment may be executed in any number of counterparts, each of which, when
executed, shall be deemed to be an original and all of which together shall constitute one and the
same document.

     10. Except as expressly amended by this Third Amendment, the Service Agreement remains in full
force and effect in accordance with its terms and hereby is ratified and conformed in all respects.
The execution, delivery, and performance of this Third Amendment shall not, except as expressly
set forth herein, operate as an amendment of any right, power or remedy under the Service
Agreement, as in effect prior to the date hereof.

     11. Upon and after the effectiveness of this Third Amendment, each reference in the Service
Agreement to “this Agreement”, “hereunder”, “herein”, “hereof” or words of like import referring to
the Service Agreement shall mean and be a reference to the Service Agreement as modified and
amended hereby. To the extent that any terms and conditions of the Service Agreement shall
contradict or be in conflict with any terms and conditions of this Third Amendment, such terms and
conditions are hereby deemed modified or amended accordingly to reflect the terms and conditions of
the Service Agreement as modified or amended hereby.

     12. This Third Amendment embodies the entire understanding and agreement between the parties
hereto with respect to the subject matter hereof and supercedes all prior agreements,
understandings, and inducements, whether express or implied, oral or written.

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     IN WITNESS WHEREOF, the parties hereto have caused this Third Amendment to be executed by
their duly authorized representatives as of the date and year first above written.

	 	 	 	 	 
	 	VENTIV COMMERCIAL SERVICES, LLC

 	 
	 	By:  	/s/ Terrell G. Herring
 	 
	 	 	Name:  	Terrell G. Herring 	 
	 	 	Title:  	President and CEO 	 
	 

	 	 	 	 	 
	 	CUMBERLAND PHARMACEUTICALS, INC.

 	 
	 	By:  	/s/ A.J. Kazimi
 	 
	 	 	Name:  	A.J. Kazimi 	 
	 	 	Title:  	CEO 	 

3

 

	 	 	 	 	 

SCHEDULE 3.1

COMPENSATION — IMPLEMENTATION FEES, FIXED FEES AND PASS-THROUGH

COSTS AND BILLING TERMS

I. FIXED FEES

     Implementation Fee.

     Cumberland shall pay Ventiv an Implementation Fee for the Additional Representatives and the
Additional Managers in the amount of $[***] within [***] days after the Effective Date.

     Fixed Monthly Fee

     Cumberland shall pay Ventiv a Fixed Monthly Fee as follows:

	 	 	 	 	 
	Monthly Fee Commencing

on the Effective Date and 

Continuing Until the Hire 

Date
	 	Monthly Fee

Commencing on the Hire

Date and Continuing

Until the First

Anniversary of the Hire

Date
	 	Monthly Fee

Commencing on the First

Anniversary of the Hire

Date and Continuing

Until the Second

Anniversary of the Hire

Date
	 
	 	 
	 	 
	$258,482
	 	$442,484
	 	$453,615

II. PASS-THROUGH COSTS

     In addition to the Fixed Fees, certain expenses will be charged to Cumberland on
a pass-through basis. These expenses will be billed to Cumberland at actual cost incurred by
Ventiv. Pass through expenses shall include:

 —  Manager Bonus (including employer portion of taxes)

 —  Representative Bonus (including employer portion of taxes)

 —  Manager travel (air, rail, rental, taxi, lodging and meals)

 —  Representative travel (air, rail, rental, taxi, lodging and meals)

 —  Postage associated with initial shipment of training materials

 —  National Training Meeting

 —  District Planning Meetings and National Sales Meetings

 —  Third Party data acquisition costs

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 —  Promotional Funds

 —  Physician Validation

 —  Sample Storage

 —  Travel Associated with Interviews

     Notwithstanding the foregoing, airline travel shall be via commercial airline at no more than
full coach fare, and each Manager Bonus and Representative Bonus shall be in an amount agreed in
writing by Cumberland and Ventiv before payment thereof and shall be based upon
well-defined, mutually agreed performance criteria, subject to Ventiv’s internal human resources
policies and procedures.

III. BILLING TERMS

     Cumberland will be billed monthly in arrears the amount stated above as the Fixed Monthly Fee.
Pass-through Costs will be billed to Cumberland at actual cost as incurred by Ventiv.

     Invoices are due [***] days from date of invoice. If not paid within [***] days of the date
of invoice, there will be a finance charge of 1.5% monthly, applied to the outstanding balance due.

5EX-10.9.1

EXHIBIT 10.9.1

* Certain portions of this exhibit have been omitted pursuant to a request for confidential

treatment which has been filed separately with the SEC.

AMENDMENT TO

KRISTALOSE AGREEMENT

     This Amendment to Kristalose Agreement (the “Amendment”) is entered into this 3rd
day of April, 2008 by and between Inalco S.P.A. (“Inalco Italy”), Inalco Biochemicals, Inc.
(“Inalco U.S.”) and Cumberland Pharmaceuticals Inc. (“Cumberland”). Inalco Italy and Inalco U.S.
are hereinafter collectively referred to as “Inalco.”

     WHEREAS, Inalco and Cumberland entered into a certain Kristalose Agreement in April 2006 (the
“Agreement”); and

     WHEREAS, Inalco and Cumberland desire to amend the Kristalose Agreement in certain respects as
set forth herein.

     NOW, THEREFORE, for and in consideration of the mutual covenants and agreements hereinafter
set forth, and for other good and valuable consideration, the parties hereto agree as follows:

     1. Amendment of Section 4.1. Subsection C. (Third Installment) of Section 4.1 of the
Agreement is hereby amended by deleting “Three Million U.S. Dollars ($3,000,000 U.S.), payable upon
the third anniversary of the Effective Date of this Agreement” and substituting in lieu thereof
“Two Million Seven Hundred Sixty Thousand U.S. Dollars ($2,760,000 U.S.), payable within seven (7)
days of the date of this Amendment.”

     2. Amendment of Section 4.2. Section 4.2 (Royalty Payment) is hereby amended by
deleting from Subsection B. thereof “[***]” and substituting in lieu thereof “[***]”. Section 4.2
is hereby further amended by deleting from Subsection C. thereof “[***]” and substituting in lieu
thereof “[***].”

     3. Amendment of Section 4.3. Effective the date of this Amendment, Section 4.3
(Payment for Product) is hereby amended to reflect a one-time price increase by deleting “[***]”
and substituting in lieu thereof “[***]” and by deleting “[***]” and substituting in lieu thereof
“[***].”

     4. Capitalized terms not defined in this Amendment shall have the meaning set forth in the
Agreement.

     5. It is mutually agreed that all covenants, conditions and agreements set forth in the
Agreement (as amended hereby) shall remain binding upon the parties and inure to the benefit of the
parties hereto and their respective successors and assigns.

1

 

     IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed by their duly
authorized representatives effective as of the day and year first written above.

	 	 	 	 	 
	 	INALCO S.P.A

 	 
	 	By:  	/s/ Giovanni Cipolletti
 	 
	 	 	Name:  	Giovanni Cipolletti 	 
	 	 	Its: President 	 
	 

	 	 	 	 	 
	 	INALCO BIONCHEMICALS, INC.

 	 
	 	By:  	/s/ Eric Lowe
 	 
	 	 	Name:  	Eric Lowe                   	 
	 	 	Its: President 	 
	 

	 	 	 	 	 
	 	CUMBERLAND PHARMACEUTICALS INC.

 	 
	 	By:  	/s/ A.J. Kazimi
 	 
	 	 	Name:  	A.J. Kazimi                  	 
	 	 	Its: Chief Executive Officer 	 
	 

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