Document:

EX-4.3

 Exhibit 4.3 
  

 
 

 
  
  

  
 

 

 

 
  

 TABLE OF CONTENTS 

 

							
	 	  	 	  	Page	 
	   PARTIES
	  		  	 	1	 
	   RECITALS
	  		  	 	1	 
	   Section 1.
	  	Certain Definitions	  			
	 (a)
	  	 ADR Register
	  	 	1	 
	 (b)
	  	 ADRs; Direct Registration ADRs
	  	 	1	 
	 (c)
	  	 ADS
	  	 	1	 
	 (d)
	  	 Beneficial Owner
	  	 	2	 
	 (e)
	  	 CSB
	  	 	2	 
	 (f)
	  	 Custodian
	  	 	2	 
	 (g)
	  	 Deliver, execute, issue et al.
	  	 	2	 
	 (h)
	  	 Delivery Order
	  	 	2	 
	 (i)
	  	 Deposited Securities
	  	 	2	 
	 (j)
	  	 Direct Registration System
	  	 	3	 
	 (k)
	  	 Holder
	  	 	3	 
	 (l)
	  	 Securities Act of 1933
	  	 	3	 
	 (m)
	  	 Securities Exchange Act of 1934
	  	 	3	 
	 (n)
	  	 Shares
	  	 	3	 
	 (o)
	  	 Transfer Office
	  	 	3	 
	 (p)
	  	 Withdrawal Order
	  	 	3	 
	   Section 2.
	  	Form of ADRs	  	 	3	 
	   Section 3.
	  	Deposit of Shares	  	 	4	 
	   Section 4.
	  	Issue of ADRs	  	 	5	 
	   Section 5.
	  	Distributions on Deposited Securities	  	 	5	 
	   Section 6.
	  	Withdrawal of Deposited Securities	  	 	6	 
	   Section 7.
	  	Substitution of ADRs	  	 	6	 
	   Section 8.
	  	Cancellation and Destruction of ADRs; Maintenance of Records	  	 	6	 
	   Section 9.
	  	The Custodian	  	 	6	 
	   Section 10.
	  	Lists of Holders	  	 	7	 
	   Section 11.
	  	Depositary’s Agents	  	 	7	 
	   Section 12.
	  	Resignation and Removal of the Depositary; Appointment of Successor Depositary	  	 	7	 
	   Section 13.
	  	Compliance with Securities Exchange of 1934 Reporting and other Requirements; Reports	  	 	8	 
	   Section 14.
	  	Additional Shares	  	 	9	 
	   Section 15.
	  	Indemnification	  	 	10	 
	   Section 16.
	  	Notices	  	 	12	 
	   Section 17.
	  	Counterparts	  	 	13	 
	   Section 18.
	  	No Third-Party Beneficiaries; Holders and Beneficial Owners as Parties; Binding Effect	  	 	13	 
	   Section 19.
	  	Severability	  	 	13	 
	   Section 20.
	  	Governing Law; Consent to Jurisdiction	  	 	13	 
	   Section 21.
	  	Agent for Service	  	 	15	 
	   Section 22.
	  	Waiver of Immunities	  	 	15	 
	   Section 23.
	  	Waiver of Jury Trial	  	 	16	 
	   Section 24.
	  	Notification of Interests	  	 	16	 
	   Section 25.
	  	Amendment and Restatement of Prior Deposit Agreement	  	 	17	 
	 TESTIMONIUM
	  	 	15	 

  
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	 SIGNATURES
	  	 	15	 

  
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 EXHIBIT A 

 

							
		  	 	Page	 
	 FORM OF FACE OF ADR
	  	 	A-1	 
	 Introductory Paragraph
	  	 	A-1	 
	 (1)
	    	Issuance of ADSs	  	 	A-2	 
	 (2)
	    	Withdrawal of Deposited Securities	  	 	A-3	 
	 (3)
	    	Transfers, Split-Ups and Combinations of ADRs	  	 	A-4	 
	 (4)
	    	Certain Limitations to Registration, Transfer etc.	  	 	A-4	 
	 (5)
	    	Liability of Holder or Beneficial Owner for Taxes, Duties and Other Charges	  	 	A-5	 
	 (6)
	    	Disclosure of Interests	  	 	A-6	 
	 (7)
	    	Charges of Depositary	  	 	A-7	 
	 (8)
	    	Available Information	  	 	A-10	 
	 (9)
	    	Execution	  	 	A-11	 
	 Signature of Depositary
	  	 	A-10	 
	 Address of Depositary’s Office
	  	 	A-10	 
	 FORM OF REVERSE OF ADR
	  	 	A-11	 
	 (10)
	    	Distributions on Deposited Securities	  	 	A-12	 
	 (11)
	    	Record Dates	  	 	A-13	 
	 (12)
	    	Voting of Deposited Securities	  	 	A-13	 
	 (13)
	    	Changes Affecting Deposited Securities	  	 	A-14	 
	 (14)
	    	Exoneration	  	 	A-15	 
	 (15)
	    	Resignation and Removal of Depositary; the Custodian	  	 	A-18	 
	 (16)
	    	Amendment	  	 	A-19	 
	 (17)
	    	Termination	  	 	A-20	 
	 (18)
	    	Appointment; Acknowledgements and Agreements	  	 	A-20	 
	 (19)
	    	Waiver	  	 	A-21	 
	 (20)
	    	Jurisdiction	  	 	A-22	 
	 (21)
	    	Elective Distributions in Cash or Shares	  	 	A-22	 

  
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 AMENDED AND RESTATED DEPOSIT AGREEMENT, dated as of _____________ __, 2021 (the “Deposit
Agreement”), among EVOTEC SE and its successors (the “Company”), JPMORGAN CHASE BANK, N.A., as depositary hereunder (the “Depositary”), and all Holders (as defined below) and Beneficial Owners (as defined
below) from time to time of American Depositary Receipts (“ADRs”) issued hereunder evidencing American Depositary Shares (“ADSs”) representing deposited Shares (as defined below). The Company hereby appoints the
Depositary as depositary for the Deposited Securities (as defined below) and hereby authorizes and directs the Depositary to act in accordance with the terms set forth in this Deposit Agreement. All capitalized terms used herein have the meanings
ascribed to them in Section 1 or elsewhere in this Deposit Agreement. 
 WHEREAS, the Company and the Depositary entered into a Deposit
Agreement, dated as of April 15, 2008, as amended by Amendment No. 1 thereto, dated as of December 30, 2010 (as previously amended, the “Prior Deposit Agreement”), for the purposes set forth therein, for the creation
of ADSs representing the Shares so deposited and for the execution and delivery of ADRs (“Prior Receipts”) evidencing the ADSs; 

WHEREAS, pursuant to the terms of the Prior Deposit Agreement, the Company and the Depositary wish to amend and restate the Prior Deposit Agreement and
the Prior Receipts; 
 NOW THEREFORE, in consideration of the premises, subject to Section 24 hereof, the parties hereto hereby amend and
restate the Prior Deposit Agreement and the Prior Receipts in their entirety as follows: 
 1. Certain Definitions. 

(a)      “ADR Register” is defined in paragraph (3) of the form of ADR (Transfers, Split-Ups and Combinations of ADRs). 
 (b)      “ADRs” mean the
American Depositary Receipts executed and delivered hereunder. ADRs may be either in physical certificated form or Direct Registration ADRs (as hereinafter defined). ADRs in physical certificated form, and the terms and conditions governing the
Direct Registration ADRs, shall be substantially in the form of Exhibit A annexed hereto (the “form of ADR”). The term “Direct Registration ADR” means an ADR, the ownership of which is recorded on the Direct
Registration System. References to “ADRs” shall include certificated ADRs and Direct Registration ADRs, unless the context otherwise requires. The form of ADR is hereby incorporated herein and made a part hereof; the provisions of the form
of ADR shall be binding upon the parties hereto. 
 (c)      Subject to paragraph (13) of the form of ADR
(Changes Affecting Deposited Securities), each “ADS” evidenced by an ADR represents the right to 

  
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receive, and to exercise the beneficial ownership interests in, the number of Shares specified in the form of ADR attached hereto as Exhibit A (as amended from time to time) that are on deposit
with the Depositary and/or the Custodian and a pro rata share in any other Deposited Securities, subject, in each case, to the terms of this Deposit Agreement and the ADSs. The
ADS(s)-to-Share(s) ratio is subject to amendment as provided in the form of ADR (which may give rise to fees contemplated in paragraph (7) thereof (Charges of
Depositary)). 
 (d)     “Beneficial Owner” means as to any ADS, any person or entity having a
beneficial ownership interest in such ADS. A Beneficial Owner need not be the Holder of the ADR evidencing such ADS. If a Beneficial Owner of ADSs is not a Holder, it must rely on the Holder of the ADR(s) evidencing such ADSs in order to assert any
rights or receive any benefits under this Deposit Agreement. The arrangements between a Beneficial Owner of ADSs and the Holder of the corresponding ADRs may affect the Beneficial Owner’s ability to exercise any rights it may have. 

(e)     “CSB” means Clearstream Banking AG, the German central securities depositary, and any successor
entity. 
 (f)      “Custodian” means the agent or agents of the Depositary (singly or collectively, as
the context requires) and any additional or substitute Custodian appointed pursuant to Section 9. 
 (g)     The terms
“deliver,” “execute,” “issue,” “register,” “surrender,” “transfer” or “cancel,” when used with respect to (i) Shares refers,
where the context requires, to an entry or entries or an electronic transfer or transfers in an account or accounts maintained by institutions authorized under applicable law to effect transfers of securities (which may include the CSB) and not to
the physical transfer of certificates representing the Shares and (ii) Direct Registration ADRs, shall refer to an entry or entries or an electronic transfer or transfers in the Direct Registration System, and, when used with respect to ADRs in
physical certificated form, shall refer to the physical delivery, execution, issuance, registration, surrender, transfer or cancellation of certificates representing the ADRs. 

(h)     “Delivery Order” is defined in Section 3. 

(i)      “Deposited Securities” as of any time means all Shares at such time deposited under this Deposit
Agreement and any and all other Shares, securities, property and cash at such time held by the Depositary or the Custodian in respect or in lieu of such deposited Shares and other Shares, securities, property and cash. Deposited Securities are not
intended to, and shall not, constitute proprietary assets of the Depositary, the Custodian or their nominees. Beneficial ownership in Deposited Securities is intended to be, and shall at all times during the term of the Deposit Agreement continue to
be, vested in the Beneficial Owners of the ADSs representing such Deposited Securities. 

  
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 (j)       “Direct Registration System” means the
system for the uncertificated registration of ownership of securities established by The Depository Trust Company (“DTC”) and utilized by the Depositary pursuant to which the Depositary may record the ownership of ADRs without the
issuance of a certificate, which ownership shall be evidenced by periodic statements issued by the Depositary to the Holders entitled thereto. For purposes hereof, the Direct Registration System shall include access to the Profile Modification
System maintained by DTC, which provides for automated transfer of ownership between DTC and the Depositary. 

(k)      “Holder” means the person or persons in whose name an ADR is registered on the ADR Register. For
all purposes under the Deposit Agreement and the ADRs, a Holder shall be deemed to have all requisite authority to act on behalf of any and all Beneficial Owners of the ADSs evidenced by the ADR(s) registered in such Holder’s name. 

(l)       “Securities Act of 1933” means the United States Securities Act of 1933, as from time to
time amended. 
 (m)     “Securities Exchange Act of 1934” means the United States Securities Exchange Act
of 1934, as from time to time amended. 
 (n)      “Shares” mean the ordinary bearer shares, as amended
or redenominated from time to time, of the Company, and shall include the rights to receive Shares specified in paragraph (1) of the form of ADR (Issuance of ADSs). 

(o)      “Transfer Office” is defined in paragraph (3) of the form of ADR (Transfers, Split-Ups and Combinations of ADRs). 
 (p)      “Withdrawal
Order” is defined in Section 6. 
 2.  Form of ADRs. 

(a)      Direct Registration ADRs. Notwithstanding anything in this Deposit Agreement or in the form of ADR to the
contrary, ADSs shall be evidenced by Direct Registration ADRs, unless certificated ADRs are specifically requested by the Holder. 

(b)      Certificated ADRs. ADRs in certificated form shall be printed or otherwise reproduced at the discretion of
the Depositary in accordance with its customary practices in its American depositary receipt business, or at the request of the Company typewritten and photocopied on plain or safety paper, and shall be substantially in the form set forth in the
form of ADR, with such changes as may be required by the Depositary or the Company to comply with their obligations hereunder, any applicable law, regulation or usage or to indicate any special limitations or restrictions to which any particular
ADRs are subject. ADRs may be 

  
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issued in denominations of any number of ADSs. ADRs in certificated form shall be executed by the Depositary by the manual or facsimile signature of a duly authorized officer of the Depositary.
ADRs in certificated form bearing the facsimile signature of anyone who was at the time of execution a duly authorized officer of the Depositary shall bind the Depositary, notwithstanding that such officer has ceased to hold such office prior to the
delivery of such ADRs. 
 (c)      Binding Effect. Holders of ADRs, and the Beneficial Owners of the ADSs
evidenced by such ADRs, shall each be bound by the terms and conditions of this Deposit Agreement and of the form of ADR, regardless of whether such ADRs are Direct Registration ADRs or certificated ADRs. 

3.  Deposit of Shares. 

(a)      Requirements. Shares may be deposited under this Deposit Agreement by delivery thereof to the Custodian,
at the account maintained by the Custodian for such purpose at the CSB. Shares or evidence of rights to receive Shares may be deposited through (x) the electronic transfer of such Shares to the account maintained by the Custodian for such
purpose at the CSB, (y) evidence satisfactory to the Custodian of irrevocable instructions to cause such Shares to be transferred to such account or (z) delivery of certificates representing such Shares. If use of the CSB book-entry system
in connection with the ADSs is discontinued at any time for any reason, the Company shall make such other book-entry arrangements as may be reasonably requested by the Depositary. In connection with the deposit of Shares hereunder, the Depositary or
the Custodian may require the following in a form satisfactory to it: 
 (i)        a written
order directing the Depositary to issue to, or upon the written order of, the person or persons designated in such order a Direct Registration ADR or ADRs evidencing the number of ADSs representing such deposited Shares (a “Delivery
Order”); 
 (ii)       proper endorsements or duly executed instruments of transfer in
respect of such deposited Shares; 
 (iii)      instruments assigning to the Depositary, the Custodian
or a nominee of either any distribution on or in respect of such deposited Shares or indemnity therefor; and 

(iv)      proxies entitling the Custodian to vote such deposited Shares. 

(b)      Registration of Deposited Securities. As soon as practicable after the Custodian receives Deposited
Securities pursuant to any such deposit or pursuant to paragraph (10) (Distributions on Deposited Securities) or (13) (Changes Affecting Deposited Securities) of the form of ADR, the Custodian shall present such Deposited

  
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Securities for registration of transfer into the name of the Depositary, the Custodian or a nominee of either, in each case for the benefit of Holders, to the extent such registration is
practicable, at the cost and expense of the person making such deposit (or for whose benefit such deposit is made) and shall obtain evidence satisfactory to it of such registration. Deposited Securities shall be held by the Custodian for the account
and to the order of the Depositary for the benefit of Holders of ADRs (to the extent not prohibited by law) at its account at CSB (to the extent eligible for deposit with CSB) or at such other place or places and in such manner as the Depositary
shall determine. Notwithstanding anything else contained herein, in the form of ADR and/or in any outstanding ADSs, the Depositary, the Custodian and their respective nominees are intended to be, and shall at all times during the term of the Deposit
Agreement be, the record holder(s) only of the Deposited Securities represented by the ADSs for the benefit of the Holders. The Depositary, on its own behalf and on behalf of the Custodian and their respective nominees, disclaims any beneficial
ownership interest in the Deposited Securities held on behalf of the Holders. 
 (c)      Delivery of Deposited
Securities. Deposited Securities may be delivered by the Custodian to any person only under the circumstances expressly contemplated in this Deposit Agreement. To the extent that the provisions of or governing the Shares make delivery of
certificates therefor impracticable, Shares may be deposited hereunder by such delivery thereof as the Depositary or the Custodian may reasonably accept, including, without limitation, by causing them to be credited to an account maintained by the
Custodian for such purpose with the Company or an accredited intermediary, such as a bank, acting as a registrar for the Shares, together with delivery of the documents, payments and Delivery Order referred to herein to the Custodian or the
Depositary. 
 4.  Issue of ADRs. After any such deposit of Shares, the Custodian shall notify the Depositary of such deposit and of
the information contained in any related Delivery Order by letter, first class airmail postage prepaid, or, at the request, risk and expense of the person making the deposit, by SWIFT, cable, telex, email or facsimile transmission. After receiving
such notice from the Custodian, the Depositary, subject to this Deposit Agreement, shall properly issue at the Transfer Office, to or upon the order of any person named in such notice, an ADR or ADRs registered as requested and evidencing the
aggregate ADSs to which such person is entitled. 
 5.  Distributions on Deposited Securities. To the extent that the Depositary
determines in its discretion that any distribution pursuant to paragraph (10) of the form of ADR (Distributions on Deposited Securities) is not practicable with respect to any Holder, the Depositary may (after consultation with the
Company if practicable in the case where the Depositary believes such distribution is not practicable with respect to all Holders) make such distribution as it so deems practicable, including the distribution of foreign currency, securities or
property (or appropriate documents evidencing the right to receive foreign currency, securities or property) or the 

  
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retention thereof as Deposited Securities with respect to such Holder’s ADRs (without liability for interest thereon or the investment thereof). 

6.  Withdrawal of Deposited Securities. In connection with any surrender of an ADR for withdrawal of the Deposited Securities
represented by the ADSs evidenced thereby, the Depositary may require proper endorsement in blank of such ADR (or duly executed instruments of transfer thereof in blank) and the Holder’s written order directing the Depositary to cause the
Deposited Securities represented by the ADSs evidenced by such ADR to be withdrawn and delivered to, or upon the written order of, any person designated in such order (a “Withdrawal Order”). Directions from the Depositary to the
Custodian to deliver Deposited Securities shall be given by letter, first class airmail postage prepaid, or, at the request, risk and expense of the Holder, by SWIFT, cable, telex, email or facsimile transmission. Delivery of Deposited Securities
may be made by the delivery of certificates (which, if required by law shall be properly endorsed or accompanied by properly executed instruments of transfer or, if such certificates may be registered, registered in the name of such Holder or as
ordered by such Holder in any Withdrawal Order) or by such other means as the Depositary may deem practicable, including, without limitation, by transfer of record ownership thereof to an account designated in the Withdrawal Order maintained either
by the Company or an accredited intermediary, such as a bank, acting as a registrar for the Deposited Securities. The Company agrees to cooperate with the Depositary and any registrar of the Deposited Securities in order to effectuate the withdrawal
and transfer of the Deposited Securities upon any cancellation of ADRs by Holders and/or Beneficial Owners thereof. 
 7.  Substitution
of ADRs. The Depositary shall execute and deliver a new Direct Registration ADR in exchange and substitution for any mutilated certificated ADR upon cancellation thereof or in lieu of and in substitution for such destroyed, lost or stolen
certificated ADR, unless the Depositary has notice that such ADR has been acquired by a bona fide purchaser, upon the Holder thereof filing with the Depositary a request for such execution and delivery and a sufficient indemnity bond and satisfying
any other reasonable requirements imposed by the Depositary. 
 8.  Cancellation and Destruction of ADRs; Maintenance of Records. All
ADRs surrendered to the Depositary shall be cancelled by the Depositary. The Depositary is authorized to destroy ADRs in certificated form so cancelled in accordance with its customary practices. The Depositary agrees to maintain or cause its agents
to maintain records of all ADRs surrendered and Deposited Securities withdrawn under Section 6 hereof and paragraph (2) of the form of ADR (Withdrawal of Deposited Securities), substitute ADRs delivered under Section 7 hereof,
and canceled or destroyed ADRs under this Section 8, in keeping with the procedures ordinarily followed by stock transfer agents located in the United States or as required by the laws or regulations governing the Depositary. 

9.  The Custodian. 

  
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 (a)      Rights of the Depositary. Any Custodian in acting
hereunder shall be subject to the directions of the Depositary and shall be responsible solely to it. The Depositary reserves the right to add, replace or remove a Custodian. The Depositary will give prompt, written notice of any such action, which
will be advance notice if practicable. The Depositary may discharge any Custodian at any time upon notice to the Custodian being discharged. 

(b)      Rights of the Custodian. Any Custodian may resign from its duties hereunder by providing at least 30
days’ prior written notice to the Depositary. Any Custodian ceasing to act hereunder as Custodian shall deliver, upon the instruction of the Depositary, all Deposited Securities held by it to a Custodian continuing to act. 

(c)      Notwithstanding anything to the contrary contained in this Deposit Agreement (including the ADRs) and, subject to
the further limitations set forth in clause (o) of paragraph (14) of the form of ADR (Exoneration), the Depositary shall not be responsible for, and shall incur no liability in connection with or arising from, any act or omission to
act on the part of the Custodian except to the extent that any Holder has incurred liability directly as a result of the Custodian having (i) committed fraud or willful misconduct in the provision of custodial services to the Depositary or
(ii) failed to use reasonable care in the provision of custodial services to the Depositary as determined in accordance with the standards prevailing in the jurisdiction in which the Custodian is located. 

10.  Lists of Holders. The Company shall have the right to inspect transfer records of the Depositary and its agents and the ADR
Register, take copies thereof and require the Depositary and its agents to supply copies of such portions of such records as the Company may request. The Depositary or its agents shall furnish to the Company promptly upon the written request of the
Company, a list of the names, addresses and holdings of ADSs by all Holders as of a date within seven days of the Depositary’s receipt of such request. 

11.  Depositary’s Agents. The Depositary may perform its obligations under this Deposit Agreement through any agent appointed by
it, provided that the Depositary shall notify the Company of such appointment and shall remain responsible for the performance of such obligations as if no agent were appointed, subject to paragraph (14) of the form of ADR (Exoneration).

 12.  Resignation and Removal of the Depositary; Appointment of Successor Depositary. 

(a)      Resignation of the Depositary. The Depositary may at any time resign as Depositary hereunder by
written notice of its election to do so delivered to the Company, such resignation to take effect upon the appointment of a successor depositary and its acceptance of such appointment as hereinafter provided. 

  
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 (b)      Removal of the Depositary. The Depositary may at any time
be removed by the Company by providing no less than 60 days’ prior written notice of such removal to the Depositary, such removal to take effect on the later of (i) the 60th day after
such notice of removal is first provided and (ii) the appointment of a successor depositary and its acceptance of such appointment as hereinafter provided. Notwithstanding the foregoing, if upon the resignation or removal of the Depositary a
successor depositary is not appointed within the applicable 60-day period as specified in paragraph (17) of the form of ADR (Termination), then the Depositary may elect to terminate this Deposit Agreement and the ADR and the provisions
of said paragraph (17) shall thereafter govern the Depositary’s obligations hereunder. 

(c)      Appointment of Successor Depositary. In case at any time the Depositary acting hereunder shall resign or
be removed, the Company shall use its reasonable best efforts to appoint a successor depositary, which shall be a bank or trust company having an office in the Borough of Manhattan, The City of New York. Every successor depositary shall execute and
deliver to its predecessor and to the Company an instrument in writing accepting its appointment hereunder, and thereupon such successor depositary, without any further act or deed, shall become fully vested with all the rights, powers, duties and
obligations of its predecessor. The predecessor depositary, only upon payment of all sums due to it and on the written request of the Company, shall (i) execute and deliver an instrument transferring to such successor all rights and powers of
such predecessor hereunder (other than its rights to indemnification and fees owing, each of which shall survive any such removal and/or resignation), (ii) duly assign, transfer and deliver all right, title and interest to the Deposited
Securities to such successor, and (iii) deliver to such successor a list of the Holders of all outstanding ADRs. Any such successor depositary shall promptly mail notice of its appointment to such Holders. Any bank or trust company into or with
which the Depositary may be merged or consolidated, or to which the Depositary shall transfer substantially all its American depositary receipt business, shall be the successor of the Depositary without the execution or filing of any document or any
further act. 
 13.  Compliance with Securities Exchange Act of 1934 Reporting and Other Requirements; Reports. 

(a)      Securities Exchange Act of 1934. Upon effectiveness of the Company’s registration under Section 12 of
the Securities Exchange Act of 1934, the Company will be subject to the periodic reporting requirements of the Securities Exchange Act of 1934 and accordingly will file certain reports with the Securities Exchange Commission (the
“Commission”). Such reports and other information can be inspected and retrieved by Holders and Beneficial Owners through the Commission’s EDGAR system on the Commission’s Internet Web site located at the date of this
Deposit Agreement at www.sec.gov and can be inspected and copied at public reference facilities maintained by the Commission located at the date of this Deposit Agreement at 100 F Street, NE, Washington, DC 20549. The Company represents and warrants
that as of 

  
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the date of the Deposit Agreement, it is in compliance with the registration, reporting and other requirements of the Securities Exchange Act of 1934 and hereby covenants and agrees to publish
and file all reports, and to take all other actions, necessary and/or required to remain in compliance with the registration, reporting and other requirements of the Securities Exchange Act of 1934 as and when required at all times hereafter in
order to remain in compliance with such registration, reporting and other requirements. The Company agrees to promptly notify the Depositary in the event of any change in the truth of any such representations, warranties, covenants and agreements.
The Company, and each Holder and Beneficial Owner of an ADR and/or an interest therein by so holding or owning an ADR and/or an interest therein, acknowledges and agrees that the Depositary does not assume any duty or responsibility to
determine if the Company is in compliance with the current registration, reporting and other requirements of the Securities Exchange Act of 1934 or to take any action if the Company is not complying with those requirements, and (ii) the
Depositary is relying solely on the representations, warranties, covenants and agreements of the Company in this Section 13(a) and paragraph (8) (Available Information) of the Form of ADR in connection therewith and may, and is expressly
authorized by the Company and each Holder and Beneficial Owner of an ADR and/or an interest therein to, so rely on, and represent, warrant and certify that the Company is compliant with the registration, reporting and other requirements of the
Securities Exchange Act of 1934 based on such representations, warranties, covenants and agreements of the Company. 

(b)      Reports. On or before the first date on which the Company makes any communication available to Holders of
Deposited Securities or any securities regulatory authority or stock exchange, by publication or otherwise that could reasonably be expected to affect or impact the ADRs, the ADSs, Deposited Securities or the respective holders thereof, including
without limitation, the rights, benefits, duties and/or obligations with respect to the Depositary and the Company thereto, the Company shall transmit to the Depositary a copy thereof in English or with an English translation or summary. The Company
has delivered to the Depositary, the Custodian and any Transfer Office a copy of all provisions of or governing the Shares and any other Deposited Securities issued by the Company or any affiliate of the Company and, promptly upon any change
thereto, the Company shall deliver to the Depositary, the Custodian and any Transfer Office a copy (in English or with an English translation) of such provisions as so changed. The Depositary and its agents may rely upon the Company’s delivery
of all such communications, information and provisions for all purposes of this Deposit Agreement and the Depositary shall have no liability for the accuracy or completeness of any thereof. 

14. Additional Shares. The Company agrees with the Depositary that neither the Company nor any company controlling, controlled by or under common
control with the Company shall (a) issue (i) additional Shares, (ii) rights to subscribe for 

  
 9 

 

 
  

 
Shares, (iii) securities convertible into or exchangeable for Shares or (iv) rights to subscribe for any such securities or (b) deposit any Shares under this Deposit Agreement,
except, in each case, under circumstances complying in all respects with the Securities Act of 1933. At the reasonable request of the Depositary where it deems necessary, the Company will furnish the Depositary with legal opinions, in forms and from
counsels reasonably acceptable to the Depositary. The Depositary will not knowingly accept for deposit hereunder any Shares required to be registered under the Securities Act of 1933 unless a registration statement is in effect and will use
reasonable efforts to comply with written instructions of the Company not to accept for deposit hereunder any Shares identified in such instructions at such times and under such circumstances as may reasonably be specified in such instructions in
order to facilitate the Company’s compliance with the requirements of the securities laws, rules and regulations in the United States. 

15.  Indemnification. 

(a)      Indemnification by the Company. The Company shall indemnify, defend and hold harmless each of the
Depositary, the Custodian and their respective directors, officers, employees, agents and affiliates against any loss, liability or expense (including reasonable fees and expenses of counsel) that may arise out of acts performed or omitted, in
connection with the provisions of this Deposit Agreement and of the ADRs, as the same may be amended, modified or supplemented from time to time in accordance herewith (i) by either the Depositary or a Custodian or their respective directors,
officers, employees, agents and affiliates, except for any liability or expense directly arising out of the negligence or willful misconduct of the Depositary or its directors, officers, or affiliates acting in their capacities as such hereunder, or
(ii) by the Company or any of its directors, officers, employees, agents and affiliates, including, without limitation, if any of the representations and warranties of the Company contained in Section 13 hereof and/or paragraph 8 of the
Form of ADR (Available Information) were or are incorrect in any respect and/or if the Company violates or breaches any of its covenants or agreements contained therein with respect to the Securities Exchange Act of 1934 or otherwise. 

The indemnities set forth in the preceding paragraph shall also apply to any liability or expense that may arise out of any misstatement or alleged
misstatement or omission or alleged omission in any registration statement, proxy statement, prospectus (or placement memorandum), or preliminary prospectus (or preliminary placement memorandum) relating to the offer, issuance, withdrawal or sale of
ADSs or the deposit, withdrawal, offer or sale of Shares, except to the extent any such liability or expense arises out of (i) information relating to the Depositary or its agents (other than the Company), as applicable, furnished in writing by
the Depositary expressly for use in any of the foregoing documents and not changed or altered by the Company or any other person (other than the Depositary) or (ii) if such information is provided, the failure to state a material fact therein
necessary to make the information provided, in light of the circumstances under which provided, not 

  
 10 

 

 
  

 
misleading. 
 (b)      Indemnification by the Depositary.
Subject to the limitations provided for in Sections 9 and 15(c) below, the Depositary shall indemnify, defend and hold harmless the Company against any direct loss, liability or expense (including reasonable fees and expenses of counsel) incurred by
the Company in respect of this Deposit Agreement to the extent such loss, liability or expense is due to the negligence or willful misconduct of the Depositary. 

(c)      Damages or Lost Profits. Notwithstanding any other provision of this Deposit Agreement or the ADRs to the
contrary, neither the Depositary nor the Company, nor any of their respective agents shall be liable to the other for any indirect, special, punitive or consequential damages (excluding reasonable fees and expenses of counsel) or lost profits, in
each case of any form (collectively, “Special Damages”) incurred by any of them, or liable to any other person or entity (including, without limitation, Holders and Beneficial Owners) for any Special Damages, or any fees or expenses
of counsel in connection therewith, whether or not foreseeable and regardless of the type of action in which such a claim may be brought; provided, however, that (i) notwithstanding the foregoing and, for the avoidance of doubt, the Depositary
and its agents shall be entitled to legal fees and expenses in defending against any claim for Special Damages and (ii) to the extent Special Damages arise from or out of a claim brought by a third party (including, without limitation, Holders
and Beneficial Owners) against the Depositary or any of its agents, the Depositary and its agents shall be entitled to full indemnification from the Company for all such Special Damages, and reasonable fees and expenses of counsel in connection
therewith, unless such Special Damages are found to have been a direct result of the gross negligence or willful misconduct of the Depositary. 

(d)      Notification. In case any proceeding shall be instituted involving any person in respect of which
indemnity may be sought under this Section 15, such person (an “indemnified person”) shall notify the person from whom it is seeking indemnification (the “indemnifying person”) as promptly as reasonably
practicable of the commencement of any indemnifiable action or claim promptly after such indemnified person becomes aware of such commencement; provided, however, that the failure to notify the indemnifying party shall not relieve the
indemnifying party from liability that it may have under this Section 15 except and only to the limited extent the indemnifying person is materially prejudiced by such failure through the forfeiture of substantive rights or defenses) by such
failure; and provided, further, that the failure to notify the indemnifying party shall not relieve the indemnifying party from any liability that it may have to an indemnified party otherwise than under this Section 15. No indemnifying
person shall be liable for any settlement of any proceeding effected without its written consent (which consent shall not be unreasonably withheld, delayed or conditioned), but if settled with such indemnifying 

  
 11 

 

 
  

 
person’s written consent or if there is a final and non-appealable judgment by a court of competent jurisdiction in any such proceeding, the
indemnifying person agrees to indemnify and hold harmless each indemnified person from and against any and all losses, claims, damages, liabilities and reasonable and documented legal or other out-of-pocket expenses by reason of such settlement or judgment in accordance with and to the extent provided in the other provisions herein. No indemnifying person shall, without the prior
written consent of any indemnified person, effect any settlement of any pending or threatened proceedings in respect of which indemnity could have been sought hereunder by such indemnified person unless such settlement (i) includes an
unconditional release of such indemnified person in form and substance reasonably satisfactory to such indemnified person from all liability or claims that are the subject matter of such proceedings and (ii) does not include any statement as to
or any admission of fault, culpability, wrong doing or a failure to act by or on behalf of any indemnified person. 

(e)      Survival. The obligations set forth in this Section 15 shall survive the termination of this Deposit
Agreement and the succession or substitution of any indemnified person. 
 16.  Notices. 

(a)      Notice to Holders. Notice to any Holder shall be deemed given when first mailed, first class
postage prepaid, to the address of such Holder on the ADR Register or received by such Holder. Failure to notify a Holder or any defect in the notification to a Holder shall not affect the sufficiency of notification to other Holders or to the
Beneficial Owners of the ADSs evidenced by the ADRs held by such other Holders. Except as otherwise provided elsewhere in the Deposit Agreement, the Depositary’s only notification obligations under this Deposit Agreement and the ADRs shall be
to Holders, and the Depositary shall have no notification obligations otherwise to Beneficial Owners. The foregoing shall not affect any notification obligations the Depositary has to the Company as provided in this Deposit Agreement. Notice to a
Holder shall be deemed, for all purposes of the Deposit Agreement and the ADRs, to constitute notice to any and all Beneficial Owners of the ADSs evidenced by such Holder’s ADRs. 

(b)      Notice to the Depositary or the Company. Notice to the Depositary or the Company shall be deemed
given when first received by it at the address or by electronic transmission to the e-mail address set forth in (i) or (ii), respectively, or at such other address or email address provided by the
Depositary or the Company to the other, respectively, in the same manner as notices are required to be provided in this Section 16: 
  

	 	(i)	 JPMorgan Chase Bank, N.A. 

383 Madison Avenue, Floor 11 
 New York, New York,
10179 

  
 12 

 

 
  

 Attention: Depositary Receipts Group 

E-mail Address:
DR_Global_CSM@jpmorgan.com 
  

	 	(ii)	 Evotec SE 

Essener Bogen 7 
 22419 Hamburg, Germany 

Attention: Dr. Christian Dargel, EVP Global Head of Legal & Compliance (General Counsel) 

E-mail Address: Christian.Dargel@evotec.com 

Delivery of a notice by means of electronic messaging shall be deemed to be effective at the time of the initiation of the transmission by the sender
(as shown on the sender’s records) to the email address set forth above, notwithstanding that the intended recipient retrieves the message at a later date, fails to retrieve such message, or fails to receive such notice on account of its
failure to maintain the designated e-mail address, its failure to designate a substitute e-mail address or for any other reason. 

17.  Counterparts. This Deposit Agreement may be executed in any number of counterparts, each of which shall be deemed an original and
all of which shall constitute one instrument. Delivery of an executed signature page of this Deposit Agreement by facsimile or other electronic transmission (including “.pdf”, “.tif” or similar format) shall be effective as
delivery of a manually executed counterpart hereof. 
 18.  No Third-Party Beneficiaries; Holders and Beneficial Owners as Parties;
Binding Effect. This Deposit Agreement is for the exclusive benefit of the Company, the Depositary and the Holders and their respective successors hereunder, and, except to the extent specifically set forth in Section 15 of this Deposit
Agreement, shall not give any legal or equitable right, remedy or claim whatsoever to any other person. The Holders and Beneficial Owners from time to time shall be parties to this Deposit Agreement and shall be bound by all of the provisions
hereof. A Beneficial Owner shall only be able to exercise any right or receive any benefit hereunder solely through the Holder of the ADR(s) evidencing the ADSs owned by such Beneficial Owner. 

19.  Severability. If any provision contained in this Deposit Agreement or in the ADRs is, or becomes, invalid, illegal or
unenforceable in any respect, the remaining provisions contained herein and therein shall in no way be affected thereby. 

20.  Governing Law; Consent to Jurisdiction. 

(a)      Governing Law. The Deposit Agreement, the ADSs and the ADRs shall be governed by and construed in
accordance with the internal laws of the State of New 

  
 13 

 

 
  

 
York without giving effect to the application of the conflict of law principles thereof. 

(b)      By the Company. The Company irrevocably agrees that any legal suit, action or proceeding against or
involving the Company brought by the Depositary or any Holder or Beneficial Owner, arising out of or based upon this Deposit Agreement, the ADSs, the ADRs or the transactions contemplated herein, therein, hereby or thereby, may be instituted in any
state or federal court in New York, New York, and irrevocably waives any objection which it may now or hereafter have to the laying of venue of any such proceeding, and irrevocably submits to the non-exclusive
jurisdiction of such courts in any such suit, action or proceeding. The Company also irrevocably agrees that any legal suit, action or proceeding against or involving the Depositary brought by the Company, arising out of or based upon this Deposit
Agreement, the ADSs, the ADRs or the transactions contemplated herein, therein, hereby or thereby, may be instituted only in a state or federal court in New York, New York. 

(c)      By Holders and Beneficial Owners. By holding or owning an ADR or ADS or an interest therein, Holders and
Beneficial Owners each irrevocably agree that any legal suit, action or proceeding against or involving Holders or Beneficial Owners brought by the Company or the Depositary, arising out of or based upon this Deposit Agreement, the ADSs, the ADRs or
the transactions contemplated herein, therein, hereby or thereby, may be instituted in a state or federal court in New York, New York, and by holding or owning an ADR or ADS or an interest therein each irrevocably waives any objection which it may
now or hereafter have to the laying of venue of any such proceeding, and irrevocably submits to the non-exclusive jurisdiction of such courts in any such suit, action or proceeding. By holding or owning an ADR
or ADS or an interest therein, Holders and Beneficial Owners each also irrevocably agree that any legal suit, action or proceeding against or involving the Depositary and/or the Company brought by Holders or Beneficial Owners, arising out of or
based upon this Deposit Agreement, the ADSs, the ADRs or the transactions contemplated herein, therein, hereby or thereby, including, without limitation, claims under the Securities Act of 1933, may be instituted only in the United States District
Court for the Southern District of New York (or in the state courts of New York County in New York if either (i) the United States District Court for the Southern District of New York lacks subject matter jurisdiction over a particular dispute
or (ii) the designation of the United States District Court for the Southern District of New York as the exclusive forum for any particular dispute is, or becomes, invalid, illegal or unenforceable). 

(d)      Notwithstanding the foregoing or anything in this Deposit Agreement to the contrary, any suit, action or
proceeding against the Company based on this Deposit Agreement, the ADSs, the ADRs or the transactions contemplated herein, therein, hereby or thereby, may be instituted by the Depositary in any competent court in the Federal Republic of Germany,
the European Union, the United States and/or any other court of competent jurisdiction. 

  
 14 

 

 
  

 21.  Agent for Service. 

(a)      Appointment. The Company has appointed Evotec (US) Inc., 303B College Road, East Princeton, New Jersey
08540, as its authorized agent (the “Authorized Agent”) upon which process may be served in any such suit, action or proceeding arising out of or based on this Deposit Agreement, the ADSs, the ADRs or the transactions contemplated
herein, therein, hereby or thereby which may be instituted in any state or federal court in New York, New York by the Depositary or any Holder, and waives any other requirements of or objections to personal jurisdiction with respect thereto. Subject
to the Company’s rights to replace the Authorized Agent with another entity in the manner required were the Authorized Agent to have resigned, such appointment shall be irrevocable. 

(b)      Agent for Service of Process. The Company represents and warrants that the Authorized Agent has agreed to
act as said agent for service of process, and the Company agrees to take any and all action, including the filing of any and all documents and instruments, that may be necessary to continue such appointment in full force and effect as aforesaid. The
Company further hereby irrevocably consents and agrees to the service of any and all legal process, summons, notices and documents in any suit, action or proceeding against the Company, by service by mail of a copy thereof upon the Authorized Agent
(whether or not the appointment of such Authorized Agent shall for any reason prove to be ineffective or such Authorized Agent shall fail to accept or acknowledge such service), with a copy mailed to the Company by registered or certified air mail,
postage prepaid, to its address provided in Section 16(b) hereof. The Company agrees that the failure of the Authorized Agent to give any notice of such service to it shall not impair or affect in any way the validity of such service or any
judgment or award rendered in any suit, action or proceeding based thereon. If, for any reason, the Authorized Agent named above or its successor shall no longer serve as agent of the Company to receive service of process, notice or papers in New
York, the Company shall promptly appoint a successor that is a legal entity with offices in New York, New York, so as to serve and will promptly advise the Depositary thereof. 

(c)      Waiver of Personal Service of Process. In the event the Company fails to continue such designation and
appointment in full force and effect, the Company hereby waives personal service of process upon it and consents that any such service of process may be made by certified or registered mail, return receipt requested, directed to the Company at its
address last specified for notices hereunder, and service so made shall be deemed completed five (5) days after the same shall have been so mailed. 

22.  Waiver of Immunities. To the extent that the Company or any of its properties, assets or revenues may have or may hereafter be
entitled to, or have attributed to it, any right of immunity, on the grounds of sovereignty or otherwise, from any legal action, suit or proceeding, from the giving of any relief in any respect 

  
 15 

 

 
  

 
thereof, from setoff or counterclaim, from the jurisdiction of any court, from service of process, from attachment upon or prior to judgment, from attachment in aid of execution or judgment, or
from execution of judgment, or other legal process or proceeding for the giving of any relief or for the enforcement of any judgment, in any jurisdiction in which proceedings may at any time be commenced, with respect to its obligations, liabilities
or other matters under or arising out of or in connection with the Shares or Deposited Securities, the ADSs, the ADRs or this Deposit Agreement, the Company, to the fullest extent permitted by law, hereby irrevocably and unconditionally waives, and
agrees not to plead or claim, any such immunity and consents to such relief and enforcement. 
 23.  Waiver of Jury Trial. EACH PARTY
TO THIS DEPOSIT AGREEMENT (INCLUDING, FOR AVOIDANCE OF DOUBT, EACH HOLDER AND BENEFICIAL OWNER OF, AND/OR HOLDER OF INTERESTS IN, ADSS OR ADRS) HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A
TRIAL BY JURY IN ANY SUIT, ACTION OR PROCEEDING AGAINST THE DEPOSITARY AND/OR THE COMPANY DIRECTLY OR INDIRECTLY ARISING OUT OF, BASED ON OR RELATING IN ANY WAY TO THE SHARES OR OTHER DEPOSITED SECURITIES, THE ADSs OR THE ADRs, THE DEPOSIT AGREEMENT
OR ANY TRANSACTION CONTEMPLATED HEREIN OR THEREIN, OR THE BREACH HEREOF OR THEREOF (WHETHER BASED ON CONTRACT, TORT, COMMON LAW OR ANY OTHER THEORY), INCLUDING, WITHOUT LIMITATION, ANY SUIT, ACTION, CLAIM OR PROCEEDING UNDER THE UNITED STATES
FEDERAL SECURITIES LAWS. No provision of this Deposit Agreement or any ADR is intended to constitute a waiver or limitation of any rights which a Holder or any Beneficial Owner may have under the Securities Act of 1933 or the Securities Exchange Act
of 1934, to the extent applicable. 
 24.  Notification of Interests. In order to enable the Depositary to comply with any reporting
obligations it might have pursuant to applicable provisions of German law and the Company’s Articles of Association regarding the notification of such person’s interest in Shares, which provisions at the date of the Deposit Agreement
include Sections 33 and 34 of the Securities Trading Act (Wertpapierhandelsgesetz), the Company agrees to provide the Depositary with a written notice promptly at each such time the total number of the outstanding Shares or voting rights
change. Promptly after receipt thereof, the Depositary agrees to notify the Company of the number of Shares held by it hereunder. To the extent that the number of Shares notified to the Company by the Depositary in accordance with (ii) would
require the Depositary to file or submit a report and/or notice, or to the extent a report and/or notice has been previously filed or submitted, a further report and/or notice, in each case under German law and/or the Company’s Articles of
Association, the Company shall promptly provide the Depositary with the form of report and/or notice required to be submitted and/or filed, along with instructions as to how, when and where to submit each such report and/or notice. 

  
 16 

 

 
  

 25.  Amendment and Restatement of Prior Deposit Agreement. The Deposit Agreement
amends and restates the Prior Deposit Agreement in its entirety to consist exclusively of the Deposit Agreement, and each Prior Receipt is hereby deemed amended and restated to substantially conform to the form of ADR set forth in Exhibit A annexed
hereto, except that, to the extent any portion of such amendment and restatement impose or increase any fees or charges different from those set forth herein (other than charges in connection with foreign exchange control regulations, and taxes and
other governmental charges, delivery and other such expenses), or otherwise materially prejudice any substantial existing right of Holders of Prior Receipts or Beneficial Owners of ADSs evidenced by such Prior Receipt, such portion shall not become
effective as to such Holders or Beneficial Owners with respect to such Prior Receipt until 30 days after such Holders or Beneficial Owners shall have received notice thereof, such notice to be conclusively deemed given upon the mailing to such
Holders or Beneficial Owners of notice of such amendment and restatement which notice contains a provision whereby such Holders or Beneficial Owners can receive a copy of the form of ADR. 

[Signature page follows] 

  
 17 

 

 
  

 IN WITNESS WHEREOF, EVOTEC SE and JPMORGAN CHASE BANK, N.A. have duly executed this Deposit Agreement
as of the day and year first above set forth and all Holders and Beneficial Owners shall become parties hereto upon acceptance by them of ADSs issued in accordance with the terms hereof, or upon acquisition of any beneficial interest therein. 

 

			
	EVOTEC SE
		
	By:	 	  

		 	Name:
		 	Title:
	
	JPMORGAN CHASE BANK, N.A.
		
	By:	 	  

		 	Name:
		 	Title:

  
 [Signature Page to Deposit
Agreement] 

 

 
  

 EXHIBIT A 

ANNEXED TO AND INCORPORATED IN 
 DEPOSIT
AGREEMENT 
 [FORM OF FACE OF ADR] 
 CERTAIN
RIGHTS OF THE HOLDER OF THIS AMERICAN DEPOSITARY RECEIPT MAY BE WITHHELD IN ACCORDANCE WITH THE PROVISIONS OF PARAGRAPH (6) HEREOF, INCLUDING, WITHOUT LIMITATION, VOTING RIGHTS AND THE RIGHT TO RECEIVE DIVIDENDS AND OTHER DISTRIBUTIONS.

  

			
	        	 	 No. of ADSs:

	Number	 	

 Each ADS represents One-Half (1/2) of One Share 

CUSIP: 
 AMERICAN DEPOSITARY RECEIPT 

evidencing 
 AMERICAN DEPOSITARY SHARES 

representing 
 ORDINARY BEARER SHARES 

of 
 EVOTEC SE 

(Incorporated under the laws of the Federal Republic of Germany and the European Union) 

JPMORGAN CHASE BANK, N.A., a national banking association organized under the laws of the United States of America, as depositary hereunder (the
“Depositary”), hereby certifies that
                                         
        is the registered owner (a “Holder”) of
                                     American Depositary
Shares (“ADSs”), each (subject to paragraph (13) (Changes Affecting Deposited Securities)) representing one-half (1/2) of one ordinary bearer share (including the rights to receive
Shares 

  
 A-1 

 

 
  

 
described in paragraph (1) (Issuance of ADSs), “Shares” and, together with any other securities, cash or property from time to time held by the Depositary in respect or in
lieu of deposited Shares, the “Deposited Securities”), of EVOTEC SE, a corporation organized under the laws of the Federal Republic of Germany and the European Union (the “Company”), deposited under the Amended and
Restated Deposit Agreement, dated as of                      , 2021 (as amended from time to time, the “Deposit
Agreement”), among the Company, the Depositary and all Holders and Beneficial Owners from time to time of American Depositary Receipts issued thereunder (“ADRs”), each of whom by accepting an ADR becomes a party thereto.
The Deposit Agreement and this ADR (which includes the provisions set forth on the reverse hereof) shall be governed by and construed in accordance with the internal laws of the State of New York without giving effect to the application of the
conflict of law principles thereof. All capitalized terms used herein, and not defined herein, shall have the meanings ascribed to such terms in the Deposit Agreement. 

(1)  Issuance of ADSs. 

(a)  Issuance. This ADR is one of the ADRs issued under the Deposit Agreement. Subject to the other provisions hereof, the Depositary
may so issue ADRs for delivery at the Transfer Office (as hereinafter defined) only against deposit of: (i) Shares in a form satisfactory to the Custodian; or (ii) rights to receive Shares from the Company or any registrar, transfer agent,
clearing agent or other entity recording Share ownership or transactions. Shares or evidence of rights to receive Shares may be deposited through (x) electronic transfer of such Shares to the account maintained by the Custodian for such purpose
at the CSB, (y) evidence satisfactory to the Custodian of irrevocable instructions to cause such Shares to be transferred to such account or (z) delivery of the certificates representing such Shares. If use of the CSB book-entry system in
connection with the ADSs is discontinued at any time for any reason, the Company shall make such other book-entry arrangements as may be reasonably requested by the Depositary. At the request, risk and expense of the person depositing Shares, the
Depositary may accept deposits for forwarding to the Custodian and may deliver ADRs at a place other than its office. 

(b)  Lending. In its capacity as Depositary, the Depositary shall not lend Shares or ADSs. 

(c)  Representations and Warranties of Depositors. Every person depositing Shares under the Deposit Agreement represents and warrants
that: 
  

	 	(i)	 such Shares and the certificates therefor are duly authorized, validly issued and outstanding, fully paid, nonassessable
and legally obtained by such person, 

  

	 	(ii)	 all pre-emptive and comparable rights, if any, with respect to such Shares have
been validly waived or exercised, 

  
 A-2 

 

 
  

	 	(iii)	 the person making such deposit is duly authorized so to do, 

 

	 	(iv)	 the Shares presented for deposit are free and clear of any lien, encumbrance, security interest, charge, mortgage or
adverse claim and 

  

	 	(v)	 such Shares (A) are not “restricted securities” as such term is defined in Rule 144 under the Securities
Act of 1933 (“Restricted Securities”) unless at the time of deposit the requirements of paragraphs (c), (e), (f) and (h) of Rule 144 shall not apply and such Shares may be freely transferred and may otherwise be offered and
sold freely in the United States or (B) have been registered under the Securities Act of 1933. To the extent the person depositing Shares is an “affiliate” of the Company as such term is defined in Rule 144, the person also represents
and warrants that upon the sale of the ADSs, all of the provisions of Rule 144 that enable the Shares to be freely sold (in the form of ADSs) will be fully complied with and, as a result thereof, all of the ADSs issued in respect of such Shares will
not be on the sale thereof, Restricted Securities. 

 Such representations and warranties shall survive the deposit and withdrawal
of Shares and the issuance and cancellation of ADSs in respect thereof and the transfer of such ADSs. 
 (d)  The Depositary may refuse to
accept for such deposit any Shares identified by the Company in order to facilitate compliance with the requirements of the securities laws, rules and regulations of the United States, including, without limitation, the Securities Act of 1933 and
the rules and regulations made thereunder. 
 (2)  Withdrawal of Deposited Securities. Subject to paragraphs (4) (Certain
Limitations to Registration, Transfer etc.) and (5) (Liability of Holder or Beneficial Owner for Taxes, Duties and Other Charges), upon surrender of (a) a certificated ADR in a form satisfactory to the Depositary at the Transfer
Office or (b) proper instructions and documentation in the case of a Direct Registration ADR, in either case accompanied by such instruments of transfer as the Depositary may reasonably require, the Holder hereof is entitled to delivery
(i) to an account designated by such Holder with the CSB or an institution that maintains accounts with the CSB, of the Shares and other Deposited Securities that are eligible for deposit with the CSB and (ii) at the office of the
Custodian, of any Deposited Securities that are not eligible for deposit with the CSB, in each case at the time, underlying this ADR. At the request, risk and expense of the Holder hereof, the Depositary may deliver such Deposited Securities at such
other place as may have been requested by the Holder. Notwithstanding any other provision of the Deposit Agreement or this ADR, the 

  
 A-3 

 

 
  

 
withdrawal of Deposited Securities may be restricted only for the reasons set forth in General Instruction I.A.(1) of Form F-6 (as such instructions may be
amended from time to time) under the Securities Act of 1933. 
 (3)  Transfers, Split-Ups and
Combinations of ADRs. The Depositary or its agent will keep, at a designated transfer office (the “Transfer Office”), (a) a register (the “ADR Register”) for the registration, registration of transfer,
combination and split-up of ADRs, and, in the case of Direct Registration ADRs, shall include the Direct Registration System, which at all reasonable times will be open for inspection by Holders and the
Company for the purpose of communicating with Holders in the interest of the business of the Company or a matter relating to the Deposit Agreement and (b) facilities for the delivery and receipt of ADRs. The term ADR Register includes the
Direct Registration System. Title to this ADR (and to the Deposited Securities represented by the ADSs evidenced hereby), when properly endorsed (in the case of ADRs in certificated form) or upon delivery to the Depositary of proper instruments of
transfer, is transferable by delivery with the same effect as in the case of negotiable instruments under the laws of the State of New York; provided that the Depositary, notwithstanding any notice to the contrary, may treat the person in
whose name this ADR is registered on the ADR Register as the absolute owner hereof for all purposes and neither the Depositary nor the Company will have any obligation or be subject to any liability under the Deposit Agreement or any ADR to any
Beneficial Owner, unless such Beneficial Owner is the Holder hereof. Subject to paragraphs (4) and (5), this ADR is transferable on the ADR Register and may be split into other ADRs or combined with other ADRs into one ADR, evidencing the
aggregate number of ADSs surrendered for split-up or combination, by the Holder hereof or by duly authorized attorney upon surrender of this ADR at the Transfer Office properly endorsed (in the case of ADRs in
certificated form) or upon delivery to the Depositary of proper instruments of transfer and duly stamped as may be required by applicable law; provided that the Depositary may close the ADR Register at any time or from time to time when
deemed expedient by it or, in the case of the issuance book portion of the ADR Register, when reasonably requested by the Company solely in order to enable the Company to comply with applicable law; provided further, that the
Depositary shall have no liability and shall be indemnified by the Company in such event. At the request of a Holder, the Depositary shall, for the purpose of substituting a certificated ADR with a Direct Registration ADR, or vice versa, execute and
deliver a certificated ADR or a Direct Registration ADR, as the case may be, for any authorized number of ADSs requested, evidencing the same aggregate number of ADSs as those evidenced by the certificated ADR or Direct Registration ADR, as the case
may be, substituted. 
 (4)  Certain Limitations to Registration, Transfer, etc. Prior to the issue, registration, registration of
transfer, split-up or combination of any ADR, the delivery of any distribution in respect thereof, or, subject to the last sentence of paragraph (2) (Withdrawal of Deposited Securities), the withdrawal
of any Deposited Securities, and from time to time in the case of clause (b)(ii) of this paragraph (4), the Company, the Depositary or the Custodian may require: 

  
 A-4 

 

 
  

 (a)  payment with respect thereto of (i) any stock transfer or other tax or other
governmental charge, (ii) any stock transfer or registration fees in effect for the registration of transfers of Shares or other Deposited Securities upon any applicable register and (iii) any applicable charges as provided in paragraph
(7) (Charges of Depositary) of this ADR; 
 (b)  the production of proof satisfactory to it of (i) the identity of any
signatory and genuineness of any signature and (ii) such other information, including without limitation, information as to citizenship, residence, exchange control approval, beneficial or other ownership of, or interest in, any securities,
compliance with applicable law, regulations, provisions of or governing Deposited Securities and terms of the Deposit Agreement and this ADR, as it may deem necessary or proper; and 

(c)  compliance with such regulations as the Depositary may establish consistent with the Deposit Agreement. 

The issuance of ADRs, the acceptance of deposits of Shares, the registration, registration of transfer, split-up
or combination of ADRs or, subject to the last sentence of paragraph (2) (Withdrawal of Deposited Securities), the withdrawal of Deposited Securities may be suspended, generally or in particular instances, when the ADR Register or any
register for Deposited Securities is closed or when any such action is deemed advisable by the Depositary. 
 (5)  Liability of Holder or
Beneficial Owner for Taxes, Duties and Other Charges. 
 (a)      Liability for Taxes. If any
tax or other governmental charges (including any penalties and/or interest) shall become payable by or on behalf of the Custodian or the Depositary with respect to this ADR, any Deposited Securities represented by the ADSs evidenced hereby or any
distribution thereon, such tax or other governmental charge shall be paid by the Holder hereof to the Depositary and by holding or owning, or having held or owned, this ADR or any ADSs evidenced hereby, the Holder and all Beneficial Owners hereof
and thereof, and all prior Holders and Beneficial Owners hereof and thereof, jointly and severally, agree to indemnify, defend and save harmless each of the Depositary, the Company and their respective agents in respect of such tax or other
governmental charge. Neither the Depositary nor the Company, nor any of their respective agents, shall be liable to Holders or Beneficial Owners of the ADSs and ADRs for failure of any of them to comply with applicable tax laws, rules and/or
regulations. Notwithstanding the Depositary’s right to seek payment from current and former Beneficial Owners, by holding or owning, or having held or owned, an ADR, the Holder hereof (and prior Holder hereof) acknowledges and agrees that the
Depositary has no obligation to seek payment of amounts owing under this paragraph (5) from any current or former Beneficial Owner. 

  
 A-5 

 

 
  

 
The Depositary may refuse to effect any registration, registration of transfer, split-up or combination hereof or, subject to the last sentence of
paragraph (2) (Withdrawal of Deposited Securities), any withdrawal of such Deposited Securities until such payment is made. The Depositary may also deduct from any distributions on or in respect of Deposited Securities, or may sell by public
or private sale for the account of the Holder hereof any part or all of such Deposited Securities, and may apply such deduction or the proceeds of any such sale in payment of such tax or other governmental charge, the Holder hereof remaining liable
for any deficiency, and shall reduce the number of ADSs evidenced hereby to reflect any such sales of Shares. In connection with any distribution to Holders, the Company will remit to the appropriate governmental authority or agency all amounts (if
any) required to be withheld and owing to such authority or agency by the Company; and the Depositary and the Custodian will remit to the appropriate governmental authority or agency all amounts (if any) required to be withheld and owing to such
authority or agency by the Depositary or the Custodian. If the Depositary determines that any distribution in property other than cash (including Shares or rights) on Deposited Securities is subject to any tax that the Depositary or the Custodian is
obligated to withhold, the Depositary may dispose of all or a portion of such property in such amounts and in such manner as the Depositary deems necessary and practicable to pay such taxes, by public or private sale, and the Depositary shall
distribute the net proceeds of any such sale or the balance of any such property after deduction of such taxes to the Holders entitled thereto. 

(b)      Indemnifications Related to Taxes. Each Holder and Beneficial Owner agrees to indemnify the Depositary,
the Company, the Custodian and any of their respective officers, directors, employees, agents and affiliates against, and hold each of them harmless from, any claims by any governmental authority with respect to taxes, additions to tax, penalties or
interest arising out of any refund of taxes, reduced rate of withholding at source or other tax benefit obtained which obligations shall survive any transfer or surrender of ADSs or the termination of the Deposit Agreement. 

(6)  Disclosure of Interests. 

(a)  General. Each Holder of an ADR and all persons holding ADRs or beneficial interests in ADRs agree to comply with all applicable
provisions of German law and the Company’s Articles of Association regarding the notification of such person’s interest in Shares, which provisions at the date of the Deposit Agreement include Sections 33 and 34 of the Securities Trading
Act (Wertpapierhandelsgesetz). At the date of the Deposit Agreement, (i) the statutory notification obligations of the Securities Trading Act apply to anyone whose holding, either directly or by way of imputation pursuant to the provisions of
Section 33 et seqq. of the Securities Trading Act, of voting rights in the Company reaches or exceeds 3%, 5%, 10%, 15%, 20%, 25%, 

  
 A-6 

 

 
  

 
30%, 50% or 75% or, after having reached or exceeded any such threshold, falls below that threshold. Each beneficial owner of ADSs acknowledges that failure to provide on a timely basis any
required notification of an interest in Shares may result in withholding of certain rights, including voting and dividend rights, in respect of the Shares in which such beneficial owner of ADSs has an interest. In connection therewith, the Company
reserves the right to instruct Holders to deliver their ADSs for cancellation and withdrawal of the Deposited Securities so as to permit the Company to deal directly with the Holder thereof as a holder of Shares and Holders agree to comply with such
instructions. The Depositary agrees to cooperate with the Company in its efforts to inform Holders of the Company’s exercise of its rights under this paragraph and agrees to consult with, and provide reasonable assistance without risk,
liability or expense on the part of the Depositary, to the Company on the manner or manners in which it may enforce such rights with respect to any Holder. 

(b)  Jurisdiction Specific. 
 Any
summary of the laws and regulations of the Federal Republic of Germany and/or the European Union and/or of the terms of the Company’s constituent documents has been provided by the Company solely for the convenience of Holders, Beneficial
Owners and the Depositary. While such summaries are believed by the Company to be accurate as of the date of the Deposit Agreement, they are (i) summaries and as such may not include all aspects of the materials summarized as applicable to a
Holder or Beneficial Owner, and (ii) provided by the Company as of the date of the Deposit Agreement. The Holder or Beneficial Owner acknowledges that these laws and regulations and the Company’s constituent documents may change after the
date of the Deposit Agreement. Neither the Depositary nor the Company has any obligation to update any such summaries. 
 (7)  Charges of
Depositary. 
 (a)  Rights of the Depositary. The Depositary may charge, and collect from, (i) each person to whom ADSs are
issued, including, without limitation, issuances against deposits of Shares, issuances in respect of Share Distributions, Rights and Other Distributions (as such terms are defined in paragraph (10) (Distributions on Deposited
Securities)), issuances pursuant to a stock dividend or stock split declared by the Company, or issuances pursuant to a merger, exchange of securities or any other transaction or event affecting the ADSs or the Deposited Securities,
and (ii) each person surrendering ADSs for withdrawal of Deposited Securities or whose ADSs are cancelled or reduced for any other reason, U.S.$5.00 for each 100 ADSs (or portion thereof) issued, delivered, reduced, cancelled or
surrendered, or upon which a Share Distribution or elective distribution is made or offered (as the case may be). The Depositary may sell (by public or private sale) sufficient securities and property received in respect of Share Distributions,
Rights and Other Distributions prior to such deposit to pay such charge. 

  
 A-7 

 

 
  

 (b)  Additional charges by the Depositary. The following additional charges shall
also be incurred by the Holders, the Beneficial Owners, by any party depositing or withdrawing Shares or by any party surrendering ADSs and/or to whom ADSs are issued (including, without limitation, issuances pursuant to a stock dividend or stock
split declared by the Company or an exchange of stock regarding the ADSs or the Deposited Securities or a distribution of ADSs pursuant to paragraph (10) (Distributions on Deposited Securities)), whichever is applicable: 

 

	 	(i)	 a fee of U.S.$0.05 or less per ADS held for any Cash distribution made, or for any elective cash/stock dividend offered,
pursuant to the Deposit Agreement, 

  

	 	(ii)	 a fee for the distribution or sale of securities pursuant to paragraph (10) hereof, such fee being in an amount
equal to the fee for the execution and delivery of ADSs referred to above which would have been charged as a result of the deposit of such securities (for purposes of this paragraph (7) treating all such securities as if they were Shares) but
which securities or the net cash proceeds from the sale thereof are instead distributed by the Depositary to Holders entitled thereto,  

  

	 	(iii)	 an aggregate fee of U.S.$0.05 or less per ADS per calendar year (or portion thereof) for services performed by the
Depositary in administering the ADRs (which fee may be charged on a periodic basis during each calendar year and shall be assessed against Holders as of the record date or record dates set by the Depositary during each calendar year and shall be
payable at the sole discretion of the Depositary by billing such Holders or by deducting such charge from one or more cash dividends or other cash distributions), and 

 

	 	(iv)	 a fee for the reimbursement of such fees, charges and expenses as are incurred by the Depositary and/or any of its agents
(including, without limitation, the Custodian and expenses incurred on behalf of Holders in connection with compliance with foreign exchange control regulations or any law or regulation relating to foreign investment) in connection with the
servicing of the Shares or other Deposited Securities, the sale of securities (including, without limitation, Deposited Securities), the delivery of Deposited Securities or otherwise in connection with the Depositary’s or its Custodian’s
compliance with applicable law, rule or regulation (which fees and charges shall be assessed on a proportionate basis against Holders as of the record date or dates set by the Depositary and shall be payable at the sole discretion of the Depositary
by billing such Holders or by deducting such 

  
 A-8 

 

 
  

	 	 
charge from one or more cash dividends or other cash distributions). 

(c)  Other Obligations and Charges. The Company will pay all other charges and expenses of the Depositary and any agent of the
Depositary (except the Custodian) pursuant to agreements from time to time between the Company and the Depositary, except: 
  

	 	(i)	 stock transfer or other taxes and other governmental charges (which are payable by Holders or persons depositing Shares);

  

	 	(ii)	 SWIFT, cable, telex and facsimile transmission and delivery charges incurred at the request of persons depositing, or
Holders delivering Shares, ADRs or Deposited Securities (which are payable by such persons or Holders); and 

  

	 	(iii)	 transfer or registration fees for the registration or transfer of Deposited Securities on any applicable register in
connection with the deposit or withdrawal of Deposited Securities (which are payable by persons depositing Shares or Holders withdrawing Deposited Securities). 

(d)  Foreign Exchange Related Matters. To facilitate the administration of various depositary receipt transactions, including
disbursement of dividends or other cash distributions and other corporate actions, the Depositary may engage the foreign exchange desk within JPMorgan Chase Bank, N.A. (the “Bank”) and/or its affiliates in order to enter into spot
foreign exchange transactions to convert foreign currency into U.S. dollars (“FX Transactions”). For certain currencies, FX Transactions are entered into with the Bank or an affiliate, as the case may be, acting in a principal
capacity. For other currencies, FX Transactions are routed directly to and managed by an unaffiliated local custodian (or other third-party local liquidity provider), and neither the Bank nor any of its affiliates is a party to such FX Transactions.

 The foreign exchange rate applied to an FX Transaction will be either (i) a published benchmark rate, or (ii) a rate determined by a
third-party local liquidity provider, in each case plus or minus a spread, as applicable. The Depositary will disclose which foreign exchange rate and spread, if any, apply to such currency on the “Disclosures” page (or successor page) of
www.adr.com (as updated by the Depositary from time to time, “ADR.com”). Such applicable foreign exchange rate and spread may (and neither
the Depositary, the Bank nor any of their affiliates is under any obligation to ensure that such rate does not) differ from rates and spreads at which comparable transactions are entered into with other customers or the range of foreign exchange
rates and spreads at which the Bank or any of its affiliates enters into foreign exchange transactions in the relevant currency pair on the date of the FX 

  
 A-9 

 

 
  

 
Transaction. Additionally, the timing of execution of an FX Transaction varies according to local market dynamics, which may include regulatory requirements, market hours and liquidity in the
foreign exchange market or other factors. Furthermore, the Bank and its affiliates may manage the associated risks of their position in the market in a manner they deem appropriate without regard to the impact of such activities on the Company, the
Depositary, Holders or Beneficial Owners. The spread applied does not reflect any gains or losses that may be earned or incurred by the Bank and its affiliates as a result of risk management or other hedging related activity. 

Notwithstanding the foregoing, to the extent the Company provides U.S. dollars to the Depositary, neither the Bank nor any of its affiliates will
execute an FX Transaction as set forth herein. In such case, the Depositary will distribute the U.S. dollars received from the Company. 
 Further
details relating to the applicable foreign exchange rate, the applicable spread and the execution of FX Transactions will be provided by the Depositary on ADR.com. The Company, Holders and Beneficial Owners each acknowledge and agree that the terms
applicable to FX Transactions disclosed from time to time on ADR.com will apply to any FX Transaction executed pursuant to the Deposit Agreement. 

(e)  The right of the Depositary to receive payment of fees, charges and expenses as provided above shall survive the termination of the
Deposit Agreement. As to any Depositary, upon the resignation or removal of such Depositary, such right shall extend for those fees, charges and expenses incurred prior to the effectiveness of such resignation or removal. 

(f)  Disclosure of Potential Depositary Payments. The Depositary anticipates reimbursing the Company for certain expenses incurred by
the Company that are related to the establishment and maintenance of the ADR program upon such terms and conditions as the Company and the Depositary may agree from time to time. The Depositary may make available to the Company a set amount or a
portion of the Depositary fees charged in respect of the ADR program or otherwise upon such terms and conditions as the Company and the Depositary may agree from time to time. 

(8)  Available Information. The Deposit Agreement, the provisions of or governing Deposited Securities and any written communications
from the Company, which are both received by the Custodian or its nominee as a holder of Deposited Securities and made generally available to the holders of Deposited Securities, are available for inspection by Holders at the offices of the
Depositary and the Custodian, at the Transfer Office, on the website of the United States Securities and Exchange Commission (the “Commission”), or upon request from the Depositary (which request may be refused by the Depositary at
its discretion). The Depositary will distribute 

  
 A-10 

 

 
  

 
copies of such communications (or English translations or summaries thereof) to Holders when furnished by the Company. Upon effectiveness of the Company’s registration under Section 12 of
the Securities Exchange Act of 1934, the Company will be subject to the periodic reporting requirements of the Securities Exchange Act of 1934 and accordingly will file certain reports with the Commission. Such reports and other information can be
inspected and retrieved by Holders and Beneficial Owners through the Commission’s EDGAR system on the Commission’s Internet Web site located at the date of this Deposit Agreement at www.sec.gov and can be inspected and copied at public
reference facilities maintained by the Commission located at the date of this Deposit Agreement at 100 F Street, NE, Washington, DC 20549. The Company represents and warrants that as of the date of the Deposit Agreement, it is in compliance with the
registration, reporting and other requirements of the Securities Exchange Act of 1934 and hereby covenants and agrees to publish and file all reports, and to take all other actions, necessary and/or required to remain in compliance with the
registration, reporting and other requirements of the Securities Exchange Act of 1934 as and when required at all times hereafter in order to remain in compliance with such registration, reporting and other requirements. Each Holder and Beneficial
Owner of an ADR and/or an interest therein by so holding or owning an ADR and/or an interest therein, acknowledges and agrees that the Depositary does not assume any duty or responsibility to determine if the Company is in compliance with the
current registration, reporting and other requirements of the Securities Exchange Act of 1934 or to take any action if the Company is not complying with those requirements, and (ii) the Depositary is relying solely on the representations,
warranties, covenants and agreements of the Company in Section 13(a) of the Deposit Agreement and this paragraph (8) (Available Information) in connection therewith and may, and is expressly authorized by the Company and each Holder and
Beneficial Owner of an ADR and/or an interest therein to, so rely on, and represent, warrant and certify that the Company is compliant with the registration, reporting and other requirements of the Securities Exchange Act of 1934 based on such
representations, warranties, covenants and agreements of the Company. 
 (9)  Execution. This ADR shall not be valid for any purpose
unless executed by the Depositary by the manual or facsimile signature of a duly authorized officer of the Depositary. 
 Dated: 

 

			
	JPMORGAN CHASE BANK, N.A., as Depositary
		
	By	 	
                      
   

	Authorized Officer

 The Depositary’s office is located at 383 Madison Avenue, Floor 11, New York, New York 10179. 

  
 A-11 

 

 
  

 [FORM OF REVERSE OF ADR] 

(10)  Distributions on Deposited Securities. Subject to paragraphs (4) (Certain Limitations to Registration, Transfer etc.) and
(5) (Liability of Holder or Beneficial Owner for Taxes, Duties and other Charges), to the extent practicable, the Depositary will distribute to each Holder entitled thereto on the record date set by the Depositary therefor at such
Holder’s address shown on the ADR Register, in proportion to the number of Deposited Securities (on which the following distributions on Deposited Securities are received by the Custodian) represented by ADSs evidenced by such Holder’s
ADRs: 
 (a)  Cash. Any U.S. dollars available to the Depositary resulting from a cash dividend or other cash distribution or the
net proceeds of sales of any other distribution or portion thereof authorized in this paragraph (10) (“Cash”), on an averaged or other practicable basis, subject to (i) appropriate adjustments for taxes withheld, (ii) such
distribution being impermissible or impracticable with respect to certain Holders, and (iii) deduction of the Depositary’s and/or its agents’ fees and expenses in (1) converting any foreign currency to U.S. dollars by sale or in
such other manner as the Depositary may determine to the extent that it determines that such conversion may be made on a reasonable basis, (2) transferring foreign currency or U.S. dollars to the United States by such means as the Depositary
may determine to the extent that it determines that such transfer may be made on a reasonable basis, (3) obtaining any approval or license of any governmental authority required for such conversion or transfer, which is obtainable at a
reasonable cost and within a reasonable time and (4) making any sale by public or private means in any commercially reasonable manner. 

(b)  Shares. (i) Additional ADRs evidencing whole ADSs representing any Shares available to the Depositary resulting from a
dividend or free distribution on Deposited Securities consisting of Shares (a “Share Distribution”) and (ii) U.S. dollars available to it resulting from the net proceeds of sales of Shares received in a Share Distribution,
which Shares would give rise to fractional ADSs if additional ADRs were issued therefor, as in the case of Cash. 
 (c)  Rights.
(i) Warrants or other instruments in the discretion of the Depositary representing rights to acquire additional ADRs in respect of any rights to subscribe for additional Shares or rights of any nature available to the Depositary as a result of
a distribution on Deposited Securities (“Rights”), to the extent that the Company timely furnishes to the Depositary evidence satisfactory to the Depositary that the Depositary may lawfully distribute the same (the Company has no
obligation to so furnish such evidence), or (ii) to the extent the Company does not so furnish such evidence and sales of Rights are practicable, any U.S. dollars available to the Depositary from the net proceeds of sales of Rights as in the
case of Cash, or (iii) to the extent the Company does not so furnish such evidence and such sales cannot practicably be accomplished by reason of the nontransferability of the Rights, limited 

  
 A-12 

 

 
  

 
markets therefor, their short duration or otherwise, nothing (and any Rights may lapse). 

(d)  Other Distributions. (i) Securities or property available to the Depositary resulting from any distribution on Deposited
Securities other than Cash, Share Distributions and Rights (“Other Distributions”), by any means that the Depositary may deem equitable and practicable, or (ii) to the extent the Depositary deems distribution of such securities
or property not to be equitable and practicable, any U.S. dollars available to the Depositary from the net proceeds of sales of Other Distributions as in the case of Cash. 

The Depositary reserves the right to utilize a division, branch or affiliate of JPMorgan Chase Bank, N.A. to direct, manage and/or execute any public
and/or private sale of securities hereunder. Such division, branch and/or affiliate may charge the Depositary a fee in connection with such sales, which fee is considered an expense of the Depositary contemplated above and/or under paragraph (7)
(Charges of Depositary). Any U.S. dollars available will be distributed by checks drawn on a bank in the United States for whole dollars and cents. Fractional cents will be withheld without liability and dealt with by the Depositary in
accordance with its then current practices. All purchases and sales of securities will be handled by the Depositary in accordance with its then current policies, which are currently set forth on the “Disclosures” page (or successor page)
of ADR.com, the location and contents of which the Depositary shall be solely responsible for. 
 (11)  Record Dates. The Depositary
may, after consultation with the Company if practicable, fix a record date (which, to the extent applicable, shall be as near as practicable to any corresponding record date set by the Company) for the determination of the Holders who shall be
responsible for the fee assessed by the Depositary for administration of the ADR program and for any expenses provided for in paragraph (7) hereof as well as for the determination of the Holders who shall be entitled to receive any distribution
on or in respect of Deposited Securities, to give instructions for the exercise of any voting rights, to receive any notice or to act in respect of other matters and only such Holders shall be so entitled or obligated. 

(12)  Voting of Deposited Securities. 

(a)  Notice of any Meeting or Solicitation. As soon as practicable after receipt of notice of any meeting at which the holders of
Shares are entitled to vote, or of solicitation of consents or proxies from holders of Shares or other Deposited Securities, the Depositary shall fix the ADS record date in accordance with paragraph (11) above provided that if the Depositary
receives a written request from the Company in a timely manner and at least 30 days or such shorter time as the parties may agree, prior to the date of such vote or meeting, the Depositary shall, at the Company’s expense, distribute to Holders
a notice (the “Voting Notice”) stating (i) final information particular to such vote and meeting and any solicitation materials, 

  
 A-13 

 

 
  

 
(ii) that each Holder on the record date set by the Depositary will, subject to any applicable provisions of the laws of the Federal Republic of Germany and the European Union, be entitled to
instruct the Depositary as to the exercise of the voting rights, if any, pertaining to the Deposited Securities represented by the ADSs evidenced by such Holder’s ADRs and (iii) the manner in which such instructions may be given, including
instructions to give a discretionary proxy to a person designated by the Company. Each Holder shall be solely responsible for the forwarding of Voting Notices to the Beneficial Owners of ADSs registered in such Holder’s name. There is no
guarantee that Holders and Beneficial Owners generally or any Holder or Beneficial Owner in particular will receive the notice described above with sufficient time to enable such Holder or Beneficial Owner to return any voting instructions to the
Depositary in a timely manner. 
 (b)      Voting of Deposited Securities. Following actual receipt by the ADR
department responsible for proxies and voting of Holders’ instructions (including, without limitation, instructions of any entity or entities acting on behalf of the nominee for DTC), the Depositary shall, in the manner and on or before the
time established by the Depositary for such purpose, endeavor to vote or cause to be voted the Deposited Securities represented by the ADSs evidenced by such Holders’ ADRs in accordance with such instructions insofar as practicable and
permitted under the provisions of or governing Deposited Securities. The Depositary will not itself exercise any voting discretion in respect of any Deposited Securities. 

(c)      Alternative Methods of Distributing Materials. Notwithstanding anything contained in the Deposit
Agreement or any ADR, the Depositary may, to the extent not prohibited by any law, rule or regulation or by the rules, regulations or requirements of the stock exchange on which the ADSs are listed, in lieu of distribution of the materials provided
to the Depositary in connection with any meeting of or solicitation of consents or proxies from holders of Deposited Securities, distribute to the Holders a notice that provides Holders with or otherwise publicizes to Holders instructions on how to
retrieve such materials or receive such materials upon request (i.e., by reference to a website containing the materials for retrieval or a contact for requesting copies of the materials). Holders are strongly encouraged to forward their
voting instructions as soon as possible. Voting instructions will not be deemed received until such time as the ADR department responsible for proxies and voting has received such instructions, notwithstanding that such instructions may have been
physically received by JPMorgan Chase Bank, N.A., as Depositary, prior to such time. 
 (13)  Changes Affecting Deposited Securities.

 (a)      Subject to paragraphs (4) (Certain Limitations to Registration, Transfer etc.) and (5) (Liability
of Holder or Beneficial Owner for Taxes, Duties and Other Charges), the Depositary may, in its discretion, and shall if reasonably requested by the Company, amend this ADR or distribute additional or amended ADRs

  
 A-14 

 

 
  

 
(with or without calling this ADR for exchange) or cash, securities or property on the record date set by the Depositary therefor to reflect any change in par value, split-up, consolidation, cancellation or other reclassification of Deposited Securities, any Share Distribution or Other Distribution not distributed to Holders or any cash, securities or property available to the
Depositary in respect of Deposited Securities from (and the Depositary is hereby authorized to surrender any Deposited Securities to any person and, irrespective of whether such Deposited Securities are surrendered or otherwise cancelled by
operation of law, rule, regulation or otherwise, to sell by public or private sale any property received in connection with) any recapitalization, reorganization, merger, consolidation, liquidation, receivership, bankruptcy or sale of all or
substantially all the assets of the Company. 
 (b)      To the extent the Depositary does not so amend this ADR or
make a distribution to Holders to reflect any of the foregoing, or the net proceeds thereof, whatever cash, securities or property results from any of the foregoing shall constitute Deposited Securities and each ADS evidenced by this ADR shall
automatically represent its pro rata interest in the Deposited Securities as then constituted. 
 (c)      Promptly
upon the occurrence of any of the aforementioned changes affecting Deposited Securities, the Company shall notify the Depositary in writing of such occurrence and as soon as practicable after receipt of such notice from the Company, may instruct the
Depositary to give notice thereof, at the Company’s expense, to Holders in accordance with the provisions hereof. Upon receipt of such instruction, the Depositary shall give notice to the Holders in accordance with the terms thereof, as soon as
reasonably practicable. 
 (14)  Exoneration. 

(a)      The Depositary, the Company, and each of their respective directors, officers, employees, agents and affiliates
and each of them shall: (i) incur or assume no liability (including, without limitation, to Holders or Beneficial Owners) (A) if any present or future law, rule, regulation, fiat, order or decree of the Federal Republic of Germany, the
European Union, the United States or any other country or jurisdiction, or of any governmental or regulatory authority or any securities exchange or market or automated quotation system, the provisions of or governing any Deposited Securities, any
present or future provision of the Company’s charter, any act of God, war, terrorism, epidemic, pandemic, nationalization, expropriation, currency restrictions, work stoppage, strike, civil unrest, revolutions, rebellions, explosions, cyber,
ransomware or malware attack, computer failure or circumstance beyond its direct and immediate control shall prevent or delay, or shall cause any of them to be subject to any civil or criminal penalty in connection with, any act which the Deposit
Agreement or this ADR provides shall be done or performed by it or them (including, without limitation, voting pursuant to paragraph (12) hereof), or (B) by reason of any non-performance or delay,
caused as aforesaid, in the performance of 

  
 A-15 

 

 
  

 
any act or things which by the terms of the Deposit Agreement it is provided shall or may be done or performed or any exercise or failure to exercise any discretion given it in the Deposit
Agreement or this ADR (including, without limitation, any failure to determine that any distribution or action may be lawful or reasonably practicable); (ii) incur or assume no liability (including, without limitation, to Holders or Beneficial
Owners) except to perform its obligations to the extent they are specifically set forth in this ADR and the Deposit Agreement without gross negligence or willful misconduct and the Depositary shall not be a fiduciary or have any fiduciary duty to
Holders or Beneficial Owners; (iii) in the case of the Depositary and its agents, be under no obligation to appear in, prosecute or defend any action, suit or other proceeding in respect of any Deposited Securities, the ADSs or this ADR;
(iv) in the case of the Company and its agents hereunder be under no obligation to appear in, prosecute or defend any action, suit or other proceeding in respect of any Deposited Securities, the ADSs or this ADR, which in its opinion may
involve it in expense or liability, unless indemnity satisfactory to it against all expense (including fees and disbursements of counsel) and liability be furnished as often as may be required; and (v) not be liable (including, without
limitation, to Holders or Beneficial Owners) for any action or inaction by it in reliance upon the advice of or information from any legal counsel, any accountant, any person presenting Shares for deposit, any Holder, or any other person believed by
it to be competent to give such advice or information and/or, in the case of the Depositary only, the Company. The Depositary shall not be liable for the acts or omissions made by, or the insolvency of, any securities depository, clearing agency or
settlement system. 
 (b)      The Depositary. The Depositary shall not be responsible for, and shall incur no
liability in connection with or arising from, the insolvency of any Custodian that is not a branch or affiliate of JPMorgan Chase Bank, N.A. The Depositary shall not have any liability for the price received in connection with any sale of
securities, the timing thereof or any delay in action or omission to act nor shall it be responsible for any error or delay in action, omission to act, default or negligence on the part of the party so retained in connection with any such sale or
proposed sale. Notwithstanding anything to the contrary contained in the Deposit Agreement (including the ADRs) and, subject to the further limitations set forth in clause (o) of this paragraph (14), the Depositary shall not be responsible for,
and shall incur no liability in connection with or arising from, any act or omission to act on the part of the Custodian except to the extent that any Holder has incurred liability directly as a result of the Custodian having (i) committed
fraud or willful misconduct in the provision of custodial services to the Depositary or (ii) failed to use reasonable care in the provision of custodial services to the Depositary as determined in accordance with the standards prevailing in the
jurisdiction in which the Custodian is located. 
 (c)      The Depositary, its agents and the Company may rely and
shall be protected in acting upon any written notice, request, direction, instruction or document believed by them to be genuine and to have been signed, presented or 

  
 A-16 

 

 
  

 
given by the proper party or parties. 
 (d)     The Depositary shall
be under no obligation to inform Holders or Beneficial Owners about the requirements of the laws, rules or regulations or any changes therein or thereto of the Federal Republic of Germany, the European Union, the United States or any other country
or jurisdiction or of any governmental or regulatory authority or any securities exchange or market or automated quotation system. 

(e)     The Depositary and its agents will not be responsible for any failure to carry out any instructions to vote any of the
Deposited Securities, for the manner in which any voting instructions are given, including instructions to give a discretionary proxy to a person designated by the Company, for the manner in which any vote is cast, including, without limitation, any
vote cast by a person to whom the Depositary is instructed to grant a discretionary proxy pursuant to paragraph (12) hereof, or for the effect of any such vote. 

(f)      The Depositary may rely upon instructions from the Company or its counsel in respect of any approval or license
required for any currency conversion, transfer or distribution. 
 (g)     The Depositary and its agents may own and deal in
any class of securities of the Company and its affiliates and in ADRs. 
 (h)     Notwithstanding anything to the contrary
set forth in the Deposit Agreement or an ADR, the Depositary and its agents may fully respond to any and all demands or requests for information maintained by or on its behalf in connection with the Deposit Agreement, any Holder or Holders, any ADR
or ADRs or otherwise related hereto or thereto to the extent such information is requested or required by or pursuant to any lawful authority, including without limitation laws, rules, regulations, administrative or judicial process, banking,
securities or other regulators. 
 (i)      None of the Depositary, the Custodian or the Company, or any of their
respective directors, officers, employees, agents or affiliates shall be liable for the failure by any Holder or Beneficial Owner to obtain the benefits of credits or refunds of non-U.S. tax paid against such
Holder’s or Beneficial Owner’s income tax liability. 
 (j)      The Depositary is under no obligation to
provide the Holders and Beneficial Owners, or any of them, with any information about the tax status of the Company. None of the Depositary, the Custodian or the Company, or any of their respective directors, officers, employees, agents and
affiliates, shall incur any liability for any tax or tax consequences that may be incurred by Holders or Beneficial Owners on account of their ownership or disposition of the ADRs or ADSs. 

  
 A-17 

 

 
  

 (k)      The Depositary shall not incur any liability for the content of
any information submitted to it by or on behalf of the Company for distribution to the Holders or for any inaccuracy of any translation thereof, for any investment risk associated with acquiring an interest in the Deposited Securities, for the
validity or worth of the Deposited Securities, for the credit-worthiness of any third party, for allowing any rights to lapse upon the terms of the Deposit Agreement or for the failure or timeliness of any notice from the Company. 

(l)       Notwithstanding anything herein or in the Deposit Agreement to the contrary, the Depositary and the
Custodian(s) may use third-party delivery services and providers of information regarding matters such as, but not limited to, pricing, proxy voting, corporate actions, class action litigation and other services in connection herewith and the
Deposit Agreement, and use local agents to provide services such as, but not limited to, attendance at any meetings of security holders of issuers. Although the Depositary and the Custodian will use reasonable care (and cause their agents to use
reasonable care) in the selection and retention of such third-party providers and local agents, they will not be responsible for any errors or omissions made by them in providing the relevant information or services. 

(m)     The Depositary shall not be liable for any acts or omissions made by a successor depositary whether in connection with
a previous act or omission of the Depositary or in connection with any matter arising wholly after the removal or resignation of the Depositary. 

(n)      The Company has agreed to indemnify the Depositary and its agents under certain circumstances and the Depositary
has agreed to indemnify the Company under certain circumstances. 
 (o)      Notwithstanding any other provision of the
Deposit Agreement or this ADR to the contrary, neither the Depositary nor any of its agents shall be liable for any indirect, special, punitive or consequential damages (including, without limitation, legal fees and expenses) or lost profits, in
each case of any form incurred by any person or entity (including, without limitation, Holders and Beneficial Owners of ADRs and ADSs), whether or not foreseeable and regardless of the type of action in which such a claim may be brought. 

(p)      No provision of the Deposit Agreement or this ADR is intended to constitute a waiver or limitation of any rights
which Holders or Beneficial Owners may have under the Securities Act of 1933 or the Securities Exchange Act of 1934, to the extent applicable. 

(15)  Resignation and Removal of Depositary; the Custodian. 

(a)      Resignation. The Depositary may resign as Depositary by written notice of its election to do so delivered
to the Company, such resignation to take 

  
 A-18 

 

 
  

 
effect upon the appointment of a successor depositary and its acceptance of such appointment as provided in the Deposit Agreement. 

(b)      Removal. The Depositary may at any time be removed by the Company by no less than 60 days’ prior
written notice of such removal, to become effective upon the later of (i) the 60th day after delivery of the notice to the Depositary and (ii) the appointment of a successor depositary and its acceptance of such appointment as provided in
the Deposit Agreement. 
 (c)      The Custodian. The Depositary may appoint substitute or additional Custodians
and the term “Custodian” refers to each Custodian or all Custodians as the context requires. 
 (16)  Amendment.
Subject to the last sentence of paragraph (2) (Withdrawal of Deposited Securities), the ADRs and the Deposit Agreement may be amended by the Company and the Depositary, provided that any amendment that imposes or increases any fees or
charges (other than stock transfer or other taxes and other governmental charges, transfer or registration fees, SWIFT, cable, telex or facsimile transmission costs, delivery costs or other such expenses), or that shall otherwise prejudice any
substantial existing right of Holders or Beneficial Owners, shall become effective 30 days after notice of such amendment shall have been given to the Holders. Every Holder and Beneficial Owner at the time any amendment to the Deposit Agreement so
becomes effective shall be deemed, by continuing to hold such ADR, to consent and agree to such amendment and to be bound by the Deposit Agreement as amended thereby. In no event shall any amendment impair the right of the Holder of any ADR to
surrender such ADR and receive the Deposited Securities represented thereby, except in order to comply with mandatory provisions of applicable law. Any amendments or supplements that (i) are reasonably necessary (as agreed by the Company and the
Depositary) in order for (a) the ADSs to be registered on Form F-6 under the Securities Act of 1933 or (b) the ADSs or Shares to be traded solely in electronic book-entry form and (ii) do not in
either such case impose or increase any fees or charges to be borne by Holders, shall be deemed not to prejudice any substantial rights of Holders or Beneficial Owners. Notwithstanding the foregoing, if any governmental body or regulatory body
should adopt new laws, rules or regulations which would require amendment or supplement of the Deposit Agreement or the form of ADR to ensure compliance therewith, the Company and the Depositary may amend or supplement the Deposit Agreement and the
ADR at any time in accordance with such changed laws, rules or regulations. Such amendment or supplement to the Deposit Agreement in such circumstances may become effective before a notice of such amendment or supplement is given to Holders or
within any other period of time as required for compliance. Notice of any amendment to the Deposit Agreement or form of ADRs shall not need to describe in detail the specific amendments effectuated thereby, and failure to describe the specific
amendments in any such notice shall not render such notice invalid, provided, however, that, in each such case, the notice given to the Holders identifies a means for Holders and 

  
 A-19 

 

 
  

 
Beneficial Owners to retrieve or receive the text of such amendment (i.e., upon retrieval from the Commission’s, the Depositary’s or the Company’s website or upon request
from the Depositary). 
 (17)  Termination. The Depositary may, and shall at the written direction of the Company, terminate the
Deposit Agreement and this ADR by mailing notice of such termination to the Holders at least 30 days prior to the date fixed in such notice for such termination; provided, however, if the Depositary shall have (i) resigned as Depositary
hereunder, notice of such termination by the Depositary shall not be provided to Holders unless a successor depositary shall not be operating hereunder within 60 days of the date of such resignation, or (ii) been removed as Depositary
hereunder, notice of such termination by the Depositary shall not be provided to Holders unless a successor depositary shall not be operating hereunder on the 60th day after the Company’s
notice of removal was first provided to the Depositary. Notwithstanding anything to the contrary herein, the Depositary may terminate the Deposit Agreement without notice to the Company, but subject to giving 30 days’ notice to the Holders,
under the following circumstances: (i) in the event of the Company’s bankruptcy or insolvency, (ii) if the Shares cease to be listed on an internationally recognized stock exchange, (iii) if the Company effects (or will effect) a
redemption of all or substantially all of the Deposited Securities, or a cash or share distribution representing a return of all or substantially all of the value of the Deposited Securities, or (iv) there occurs a merger, consolidation, sale
of assets or other transaction as a result of which securities or other property are delivered in exchange for or in lieu of Deposited Securities. 

After the date so fixed for termination, the Depositary and its agents will perform no further acts under the Deposit Agreement and this ADR, except to
receive and hold (or sell) distributions on Deposited Securities and deliver Deposited Securities being withdrawn. As soon as practicable after the date so fixed for termination, the Depositary shall use its reasonable efforts to sell the Deposited
Securities and shall thereafter (as long as it may lawfully do so) hold in an account (which may be a segregated or unsegregated account) the net proceeds of such sales, together with any other cash then held by it under the Deposit Agreement,
without liability for interest, in trust for the pro rata benefit of the Holders of ADRs not theretofore surrendered. After making such sale, the Depositary shall be discharged from all obligations in respect of the Deposit Agreement
and this ADR, except to account for such net proceeds and other cash. After the date so fixed for termination, the Company shall be discharged from all obligations under the Deposit Agreement except for its obligations to the Depositary and its
agents. 
 (18)  Appointment; Acknowledgements and Agreements. Each Holder and each Beneficial Owner, upon acceptance of any ADSs or
ADRs (or any interest in any of them) issued in accordance with the terms and conditions of the Deposit Agreement shall be deemed for all purposes to (a) be a party to and bound by the terms of the Deposit Agreement and the applicable ADR(s),
(b) appoint the Depositary 

  
 A-20 

 

 
  

 
its attorney-in-fact, with full power to delegate, to act on its behalf and to take any and all actions
contemplated in the Deposit Agreement and the applicable ADR(s), to adopt any and all procedures necessary to comply with applicable law and to take such action as the Depositary in its sole discretion may deem necessary or appropriate to carry out
the purposes of the Deposit Agreement and the applicable ADR(s), the taking of such actions to be the conclusive determinant of the necessity and appropriateness thereof, and (c) acknowledge and agree that (i) nothing in the Deposit
Agreement or any ADR shall give rise to a partnership or joint venture among the parties thereto, nor establish a fiduciary or similar relationship among such parties, (ii) the Depositary, its divisions, branches and affiliates, and their
respective agents, may from time to time be in the possession of non-public information about the Company, Holders, Beneficial Owners and/or their respective affiliates, (iii) the Depositary and its
divisions, branches and affiliates may at any time have multiple banking relationships with the Company, Holders, Beneficial Owners and/or the affiliates of any of them, (iv) the Depositary and its divisions, branches and affiliates may, from
time to time, be engaged in transactions in which parties adverse to the Company or the Holders or Beneficial Owners and/or their respective affiliates may have interests, (v) nothing contained in the Deposit Agreement or any ADR(s) shall
(A) preclude the Depositary or any of its divisions, branches or affiliates from engaging in any such transactions or establishing or maintaining any such relationships, or (B) obligate the Depositary or any of its divisions, branches or
affiliates to disclose any such transactions or relationships or to account for any profit made or payment received in any such transactions or relationships, (vi) the Depositary shall not be deemed to have knowledge of any information held by
any branch, division or affiliate of the Depositary and (vii) notice to a Holder shall be deemed, for all purposes of the Deposit Agreement and this ADR, to constitute notice to any and all Beneficial Owners of the ADSs evidenced by such
Holder’s ADRs. For all purposes under the Deposit Agreement and this ADR, the Holder hereof shall be deemed to have all requisite authority to act on behalf of any and all Beneficial Owners of the ADSs evidenced by this ADR. 

(19)  Waiver. EACH PARTY TO THE DEPOSIT AGREEMENT (INCLUDING, FOR AVOIDANCE OF DOUBT, EACH HOLDER AND BENEFICIAL OWNER OF, AND/OR
HOLDER OF INTERESTS IN, ADSS OR ADRS) HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY IN ANY SUIT, ACTION OR PROCEEDING AGAINST THE DEPOSITARY AND/OR THE COMPANY DIRECTLY OR
INDIRECTLY ARISING OUT OF, BASED ON OR RELATING IN ANY WAY TO THE SHARES OR OTHER DEPOSITED SECURITIES, THE ADSs OR THE ADRs, THE DEPOSIT AGREEMENT OR ANY TRANSACTION CONTEMPLATED HEREIN OR THEREIN, OR THE BREACH HEREOF OR THEREOF (WHETHER BASED ON
CONTRACT, TORT, COMMON LAW OR ANY OTHER THEORY), INCLUDING, WITHOUT LIMITATION, ANY SUIT, ACTION, CLAIM OR PROCEEDING UNDER THE UNITED STATES FEDERAL SECURITIES LAWS. No provision of the Deposit Agreement or this ADR is intended to constitute a
waiver or limitation of any rights which a Holder or any Beneficial Owner may have under the Securities Act of 1933 or the Securities Exchange Act of 1934, to the extent 

  
 A-21 

 

 
  

 
applicable. 
 (20)  Jurisdiction. By holding or owning an ADR or ADS or
an interest therein, Holders and Beneficial Owners each irrevocably agree that any legal suit, action or proceeding against or involving Holders or Beneficial Owners brought by the Company or the Depositary, arising out of or based upon the Deposit
Agreement, the ADSs, the ADRs or the transactions contemplated therein, herein, thereby or hereby, may be instituted in a federal or state court in New York, New York, and by holding or owning an ADR or ADS or an interest therein each irrevocably
waives any objection that it may now or hereafter have to the laying of venue of any such proceeding, and irrevocably submits to the non-exclusive jurisdiction of such courts in any such suit, action or
proceeding. By holding or owning an ADR or ADS or an interest therein, Holders and Beneficial Owners each also irrevocably agree that any legal suit, action or proceeding against or involving the Depositary brought by Holders or Beneficial Owners,
arising out of or based upon the Deposit Agreement, the ADSs, the ADRs or the transactions contemplated therein, herein, thereby or hereby, including, without limitation, claims under the Securities Act of 1933, may be instituted only in the United
States District Court for the Southern District of New York (or in the state courts of New York County in New York if either (i) the United States District Court for the Southern District of New York lacks subject matter jurisdiction over a
particular dispute or (ii) the designation of the United States District Court for the Southern District of New York as the exclusive forum for any particular dispute is, or becomes, invalid, illegal or unenforceable). 

(21)  Elective Distributions in Cash or Shares. Whenever the Company intends to distribute a dividend payable at the election of the
holders of Shares in cash or in additional Shares, the Company shall give notice thereof to the Depositary at least 30 days prior to the proposed distribution stating whether or not it wishes such elective distribution to be made available to
Holders. Upon receipt of notice indicating that the Company wishes such elective distribution to be made available to Holders, the Depositary shall consult with the Company to determine, and the Company shall assist the Depositary in its
determination, whether it is lawful and reasonably practicable to make such elective distribution available to the Holders. The Depositary shall make such elective distribution available to Holders only if (i) the Company shall have timely
requested that the elective distribution is available to Holders, (ii) the Depositary shall have determined that such distribution is reasonably practicable and (iii) the Depositary shall have received satisfactory documentation within the
terms of Section 14 of the Deposit Agreement including, without limitation, any legal opinions of counsel in any applicable jurisdiction that the Depositary in its reasonable discretion may request, at the expense of the Company. If the above
conditions are not satisfied, the Depositary shall, to the extent permitted by law, distribute to the Holders, on the basis of the same determination as is made in the local market in respect of the Shares for which no election is made, either
(x) cash or (y) additional ADSs representing such additional Shares. If the above conditions are satisfied, the Depositary shall establish a record date and establish procedures to enable Holders to

  
 A-22 

 

 
  

 
elect the receipt of the proposed dividend in cash or in additional ADSs. The Company shall assist the Depositary in establishing such procedures to the extent necessary. Nothing herein shall
obligate the Depositary to make available to Holders a method to receive the elective dividend in Shares (rather than ADSs). There can be no assurance that Holders or Beneficial Owners generally, or any Holder and/or Beneficial Owner in particular,
will be given the opportunity to receive elective distributions on the same terms and conditions as the holders of Shares. 

  
 A-23EX-4.3

 Exhibit 4.3 

PYXIS ONCOLOGY, INC. 

2019 STOCK PLAN 

ADOPTED on June 27, 2019 
  

 TABLE OF CONTENTS 

 

							
		  		  	 	Page	 
			
	 SECTION 1.
	  	 ESTABLISHMENT AND PURPOSE
	  	 	1	 
			
	 SECTION 2.
	  	 ADMINISTRATION
	  	 	1	 
	 (a)
	  	 Committees of the Board of Directors
	  	 	1	 
	 (b)
	  	 Authority of the Board of Directors
	  	 	1	 
			
	 SECTION 3.
	  	 ELIGIBILITY
	  	 	1	 
	 (a)
	  	 General Rule
	  	 	1	 
	 (b)
	  	 Ten-Percent Stockholders
	  	 	1	 
			
	 SECTION 4.
	  	 STOCK SUBJECT TO PLAN
	  	 	2	 
	 (a)
	  	 Basic Limitation
	  	 	2	 
	 (b)
	  	 Additional Shares
	  	 	2	 
			
	 SECTION 5.
	  	 TERMS AND CONDITIONS OF AWARDS OR SALES
	  	 	2	 
	 (a)
	  	 Stock Grant or Purchase Agreement
	  	 	2	 
	 (b)
	  	 Duration of Offers and Nontransferability of Rights
	  	 	2	 
	 (c)
	  	 Purchase Price
	  	 	2	 
			
	 SECTION 6.
	  	 TERMS AND CONDITIONS OF OPTIONS
	  	 	3	 
	 (a)
	  	 Stock Option Agreement
	  	 	3	 
	 (b)
	  	 Number of Shares
	  	 	3	 
	 (c)
	  	 Exercise Price
	  	 	3	 
	 (d)
	  	 Vesting and Exercisability
	  	 	3	 
	 (e)
	  	 Basic Term
	  	 	3	 
	 (f)
	  	 Termination of Service (Except by Death)
	  	 	4	 
	 (g)
	  	 Leaves of Absence
	  	 	4	 
	 (h)
	  	 Death of Optionee
	  	 	4	 
	 (i)
	  	 Restrictions on Transfer of Options
	  	 	5	 
	 (j)
	  	 No Rights as a Stockholder
	  	 	5	 
	 (k)
	  	 Modification, Extension and Assumption of Options
	  	 	5	 
	 (l)
	  	 Company’s Right to Cancel Certain Options
	  	 	5	 
			
	 SECTION 7.
	  	 TERMS AND CONDITIONS OF RESTRICTED STOCK UNITS
	  	 	6	 
	 (a)
	  	 Restricted Stock Unit Agreement
	  	 	6	 
	 (b)
	  	 Payment for Restricted Stock Units
	  	 	6	 
	 (c)
	  	 Vesting Conditions
	  	 	6	 
	 (d)
	  	 Forfeiture
	  	 	6	 
	 (e)
	  	 Voting and Dividend Rights
	  	 	6	 
	 (f)
	  	 Form and Time of Settlement of Restricted Stock Units
	  	 	6	 
	 (g)
	  	 Death of Recipient
	  	 	6	 
	 (h)
	  	 Creditors’ Rights
	  	 	6	 
	 (i)
	  	 Modification, Extension and Assumption of Restricted Stock Units
	  	 	7	 
	 (j)
	  	 Restrictions on Transfer of Restricted Stock Units
	  	 	7	 

  
 i 

							
			
	 SECTION 8.
	  	 PAYMENT FOR SHARES
	  	 	7	 
	 (a)
	  	 General Rule
	  	 	7	 
	 (b)
	  	 Services Rendered
	  	 	7	 
	 (c)
	  	 Promissory Note
	  	 	7	 
	 (d)
	  	 Surrender of Stock
	  	 	7	 
	 (e)
	  	 Cashless Exercise
	  	 	7	 
	 (f)
	  	 Net Exercise
	  	 	8	 
	 (g)
	  	 Other Forms of Payment
	  	 	8	 
			
	 SECTION 9.
	  	 ADJUSTMENT OF SHARES
	  	 	8	 
	 (a)
	  	 General
	  	 	8	 
	 (b)
	  	 Corporate Transactions
	  	 	9	 
	 (c)
	  	 Dissolution or Liquidation
	  	 	10	 
	 (d)
	  	 Reservation of Rights
	  	 	10	 
			
	 SECTION 10.
	  	 MISCELLANEOUS PROVISIONS
	  	 	10	 
	 (a)
	  	 Securities Law Requirements
	  	 	10	 
	 (b)
	  	 No Retention Rights
	  	 	10	 
	 (c)
	  	 Treatment as Compensation
	  	 	10	 
	 (d)
	  	 Governing Law
	  	 	10	 
	 (e)
	  	 Conditions and Restrictions on Shares
	  	 	11	 
	 (f)
	  	 Tax Matters
	  	 	11	 
			
	 SECTION 11.
	  	 DURATION AND AMENDMENTS; STOCKHOLDER APPROVAL
	  	 	12	 
	 (a)
	  	 Term of the Plan
	  	 	12	 
	 (b)
	  	 Right to Amend or Terminate the Plan
	  	 	12	 
	 (c)
	  	 Effect of Amendment or Termination
	  	 	12	 
	 (d)
	  	 Stockholder Approval
	  	 	12	 
			
	 SECTION 12.
	  	 DEFINITIONS
	  	 	12	 

  
 ii 

 PYXIS ONCOLOGY, INC. 2019
STOCK PLAN 
 SECTION 1. ESTABLISHMENT AND PURPOSE. 

The purpose of this Plan is to attract, incentivize and retain Employees, Outside Directors and Consultants through the grant of Awards. The
Plan provides for the direct award or sale of Shares, the grant of Options to purchase Shares and the grant of Restricted Stock Units to acquire Shares. Options granted under the Plan may be ISOs intended to qualify under Code Section 422 or
NSOs which are not intended to so qualify. 
 Capitalized terms are defined in Section 12. 

SECTION 2. ADMINISTRATION. 
 (a)
Committees of the Board of Directors. The Plan may be administered by one or more Committees. Each Committee shall consist, as required by
applicable law, of one or more members of the Board of Directors who have been appointed by the Board of Directors. Each Committee shall have such authority and be responsible for such functions as the Board of Directors has assigned to it. If no
Committee has been appointed, the entire Board of Directors shall administer the Plan. Any reference to the Board of Directors in the Plan or an Award Agreement shall be construed as a reference to the Committee (if any) to whom the Board of
Directors has assigned a particular function. 
 (b)
Authority of the Board of Directors. Subject to the provisions of the Plan, the Board of Directors shall have full authority and discretion to take
any actions it deems necessary or advisable for the administration of the Plan. Notwithstanding anything to the contrary in the Plan, with respect to the terms and conditions of awards granted to Participants outside the United States, the Board of
Directors may vary from the provisions of the Plan to the extent it determines it necessary and appropriate to do so; provided that it may not vary from those Plan terms requiring stockholder approval pursuant to Section 11(d) below. All
decisions, interpretations and other actions of the Board of Directors shall be final and binding on all Participants and all persons deriving their rights from a Participant. 

SECTION 3. ELIGIBILITY. 
 (a)
General Rule. Employees, Outside Director sand Consultants shall be eligible for the grant of Awards under the Plan. However, only Employees shall be eligible for the grant of ISOs. 

(b) Ten-Percent Stockholders. A person who owns more than 10% of the total combined voting power of all classes of
outstanding stock of the Company, its Parent or any of its Subsidiaries shall not be eligible for the grant of an ISO unless (i) the Exercise Price is at least 110% of the Fair Market Value of a Share on the Date of Grant and (ii) such ISO by
its terms is not exercisable after the expiration of five years from the Date of Grant. For purposes of this Subsection (b), in determining stock ownership, the attribution rules of Code Section 424(d) shall be applied. 

 SECTION 4. STOCK SUBJECT TO PLAN. 

(a) Basic Limitation. Not more than 4,042,408 Shares may be issued under the Plan, subject to Subsection (b) below and
Section 9 (a) . All of these Shares may be issued upon the exercise of ISOs. The Company, during the term of the Plan, shall at all times reserve and keep available sufficient Shares to satisfy the requirements of the Plan. Shares offered under
the Plan may be authorized but unissued Shares or treasury Shares. 
 (b) Additional Shares. In the event that
Shares previously issued under the Plan are forfeited to or repurchased by the Company due to failure to vest, such Shares shall be added to the number of Shares then available for issuance under the Plan. In the event that Shares that otherwise
would have been issuable under the Plan are withheld by the Company in payment of the Purchase Price, Exercise Price or withholding taxes, such Shares shall remain available for issuance under the Plan. In the event that an outstanding Option,
Restricted Stock Unit or other right for any reason expires or is canceled, the Shares allocable to the unexercised or unsettled portion of such Option, Restricted Stock Unit or other right shall remain available for issuance under the Plan. To the
extent an Award is settled in cash, the cash settlement shall not reduce the number of Shares remaining available for issuance under the Plan. Notwithstanding the foregoing, in the case of ISOs, this Subsection (b) shall be subject to any
limitations imposed under Section 422 of the Code and the treasury regulations thereunder. 
 SECTION 5. TERMS AND CONDITIONS OF AWARDS OR SALES.

 (a) Stock Grant or Purchase Agreement. Each award
of Shares under the Plan shall be evidenced by a Stock Grant Agreement between the Grantee and the Company. Each sale of Shares under the Plan (other than upon exercise of an Option) shall be evidenced by a Stock Purchase Agreement between the
Purchaser and the Company. Such award or sale shall be subject to all applicable terms and conditions of the Plan and may be subject to any other terms and conditions which are not inconsistent with the Plan and which the Board of Directors deems
appropriate for inclusion in a Stock Grant Agreement or Stock Purchase Agreement. The provisions of the various Stock Grant Agreements and Stock Purchase Agreements entered into under the Plan need not be identical. 

(b)
Duration of Offers and Nontransferability of Rights. Any right to purchase Shares under the Plan (other than an Option) shall
automatically expire if not exercised by the Purchaser within 30 days (or such other period as may be specified in the Award Agreement) after the grant of such right was communicated to the Purchaser by the Company. Such right is not transferable
and may be exercised only by the Purchaser to whom such right was granted. 
 (c) Purchase Price. The Board of
Directors shall determine the Purchase Price of Shares to be offered under the Plan at its sole discretion. The Purchase Price shall be payable in a form described in Section 8. 

  
 2 

 SECTION 6. TERMS AND CONDITIONS OF OPTIONS. 

(a) Stock Option Agreement. Each grant of an Option under the Plan shall be evidenced by a Stock
Option Agreement between the Optionee and the Company. The Option shall be subject to all applicable terms and conditions of the Plan and may be subject to any other terms and conditions that are not inconsistent with the Plan and that the Board of
Directors deems appropriate for inclusion in a Stock Option Agreement. The provisions of the various Stock Option Agreements entered into under the Plan need not be identical. 

(b) Number of Shares. Each Stock Option Agreement shall specify the number of Shares that are
subject to the Option and shall provide for the adjustment of such number in accordance with Section 9. The Stock Option Agreement shall also specify whether the Option is an ISO or an NSO. 

(c) Exercise Price. 

(i) General. Each Stock Option Agreement shall specify the Exercise Price, which shall be payable in a form described in
Section 8. Subject to the remaining provisions of this Subsection (c), the Exercise Price shall be determined by the Board of Directors in its sole discretion. 

(ii) ISOs. The Exercise Price of an ISO shall not be less than 100% of the Fair Market Value of a Share on the Date of
Grant, and a higher percentage may be required by Section 3(b) . This Subsection (c)(ii) shall not apply to an ISO granted pursuant to an assumption of, or substitution for, another incentive stock option in a manner that complies with
Code Section 424(a). 
 (iii) NSOs. Except as specifically set for thin this Subsection (c)(iii), the Exercise
Price of an NSO shall not be less than 100% of the Fair Market Value of a Share on the Date of Grant. This Subsection (c)(iii) shall not apply to an NSO granted to a person who is not a U.S. taxpayer on the Date of Grant or to an NSO that is
intended either to be exempt from Code Section 409A as a “short-termdeferral” or to comply with the requirements of Code Section 409A. In addition, this Subsection (c)(iii) shall not apply to an NSO granted pursuant to an
assumption of, or substitution for, another stock option in a manner that complies with Code Section 409A. 
 (d)
Vesting and Exercisability. Each Stock Option Agreement shall specify the date when all or any installment of the Option is to become vested and exercisable. No Option shall be exercisable unless the
Optionee (i) has delivered an executed copy of the Stock Option Agreement to the Company or (ii) otherwise agrees to be bound by the terms of the Stock Option Agreement. The Board of Directors shall determine the vesting and exercisability
provisions of the Stock Option Agreement at its sole discretion. 
 (e) Basic Term. The Stock Option Agreement
shall specify the term of the Option. The term shall not exceed 10 years from the Date of Grant, and in the case of an ISO, a shorter term may be required by Section 3(b). Subject to the preceding sentence, the Board of Directors at its sole
discretion shall determine when an Option is to expire. 

  
 3 

 (f)
Termination of Service (Except by Death). If an Optionee’s Service terminates for any reason other than the Optionee’s death, then the
Optionee’s Options shall expire on the earliest of the following dates: 
 (i) The expiration date determined pursuant
to Subsection (e) above; 
 (ii) The date three months after the termination of the optionee’s Service for any
reason other than Disability, or such earlier or later date as the Board of Directors may determine (but in no event earlier than 30 days after the termination of the optionee’s Service); or 

(iii) The date six months after the termination of the Optionee’s Service by reason of Disability, or such later date as
the Board of Directors may determine. 
 The Optionee may exercise all or part of the Optionee’s Options at any time before the expiration of such
Options under the preceding sentence, but only to the extent that such Options had become exercisable before the Optionee’s Service terminated (or became exercisable as a result of the termination) and the underlying Shares had vested before
the Optionee’s Service terminated (or vested as a result of the termination). In the event that the Optionee dies after the termination of the Optionee’s Service but before the expiration of the Optionee’s Options, all or part of such
Options may be exercised (prior to expiration) by the executors or administrators of the Optionee’s estate or by any person who has acquired such Options directly from the Optionee by beneficiary designation, bequest or inheritance, but only to
the extent that such Options had become exercisable be fore the Optionee’s Service terminated (or became exercisable as a result of the termination) and the underlying Shares had vested before the Optionee’s Service terminated (or vested
as a result of the termination). In no event will an Option, or the Shares underlying an Option, become vested and/or exercisable after termination of the Optionee’s Service unless the Board of Directors takes affirmative action or unless
expressly provided in a written agreement between the Company and the Optionee. 
 (g)
Leaves of Absence. For purposes of Subsection (f) above, Service shall be deemed to continue while the Optionee is on a bona fide leave of absence approved by the Company in writing. 

(h) Death of Optionee. If an Optionee dies while the Optionee is in Service, then the
Optionee’s Options shall expire on the earlier of the following dates: 
 (i) The expiration date determined pursuant
to Subsection (e) above; or 
 (ii) The date 12 months after the Optionee’s death, or such earlier or later date
as the Board of Directors may determine (but in no event earlier than six months after the Optionee’s death) . 

  
 4 

 All or part of the Optionee’s Options may be exercised at any time before the expiration of such
Options under the preceding sentence by the executors or administrators of the Optionee’s estate or by any person who has acquired such Options directly from the Optionee by beneficiary designation, bequest or inheritance, but only to the
extent that such Options had become exercisable before the Optionee’s death (or became exercisable as a result of the death) and the underlying Shares had vested before the Optionee’s death (or vested as a result of the Optionee’s
death). In no event will an Option, or the Shares underlying an Option, become vested and/or exercisable after the Optionee’s death unless the Board of Directors takes affirmative action or unless expressly provided in a written agreement
between the Company and the Optionee. 
 (i)
Restrictions on Transfer of Options. An Option shall be transferable by the Optionee only by (i) a beneficiary designation, (ii) a will or (iii) the
laws of descent and distribution, except as provided in the next sentence. If the Board of Directors so provides, in a Stock Option Agreement or otherwise, an NSO may be transferable to the extent permitted by Rule 701 under the Securities Act.
An ISO may be exercised during the lifetime of the Optionee only by the Optionee or by the Optionee’s guardian or legal representative. 

(j) No Rights as a Stockholder. An Optionee, or a
transferee of an Optionee, shall have no rights as a stockholder with respect to any Shares covered by the Optionee’s Option until such person submits a notice of exercise, pays the Exercise Price and satisfies all applicable withholding taxes
pursuant to the terms of such Option. 
 (k)
Modification, Extension and Assumption of Options. Within the limitations of the Plan, the Board of Directors may modify, reprice, extend or assume
outstanding Options or may accept the cancellation of outstanding options (whether granted by the Company or another issuer) in return for the grant of new Options or a different type of award for the same or a different number of Shares and at the
same or a different Exercise Price (if applicable) . The foregoing not withstanding, no modification of an Option shall, without the consent of the Optionee, impair the Optionee’s rights or increase the Optionee’s obligations under such
Option; provided, however, that a modification of an Option that is otherwise favorable to the Optionee (for example, providing the Optionee with additional time to exercise the Option after termination of employment or providing for additional
forms of payment) but causes the Option to lose its tax-favored status (for example, as an ISO) shall not require the consent of the Optionee. 

(l)
Company’s Right to Cancel Certain Options. Any other provision of the Plan or a Stock Option Agreement notwithstanding, the Company shall have
the right at any time to cancel an Option that was not granted in compliance with Rule 701 under the Securities Act. Prior to canceling such Option, the Company shall give the Optionee not less than 30 days’ notice in writing. If the
Company elects to cancel such Option, it shall deliver to the Optionee consideration with an aggregate value equal to the excess of (i) the Fair Market Value of the Shares subject to such Option as of the time of the cancellation over
(ii) the Exercise Price of such Option. The consideration may be delivered in the form of cash or cash equivalents, in the form of Shares, or a combination of both. If the consideration would be a negative amount, such Option may be cancelled
without the delivery of any consideration. 

  
 5 

 SECTION 7. TERMS AND CONDITIONS OF RESTRICTED STOCK UNITS 

(a) Restricted Stock Unit Agreement. Each grant of Restricted Stock Units under
the Plan shall be evidenced by a Restricted Stock Unit Agreement between the recipient and the Company. Such Restricted Stock Units shall be subject to all applicable terms and conditions of the Plan and may be subject to any other terms and
conditions that are not inconsistent with the Plan and which the Board of Directors deems appropriate for inclusion in a Restricted Stock Unit Agreement. The provisions of the various Restricted Stock Unit Agreements entered into under the Plan need
not be identical. 
 (b)
Payment for Restricted Stock Units. No cash consideration shall be required of the recipient in connection with the grant of Restricted Stock Units. 

(c) Vesting Conditions. Each Restricted Stock Unit Agreement shall specify the vesting requirements applicable to
the Restricted Stock Units subject thereto, which the Board of Directors shall determine in its sole discretion. 
 (d) Forfeiture.
Unless a Restricted Stock Unit Agreement provides otherwise, upon termination of the recipient’s Service and upon such other times specified in the Restricted Stock Unit Agreement, any unvested Restricted Stock Units shall be forfeited to the
Company. 
 (e) Voting and Dividend Rights. The holders of Restricted Stock
Units shall have no voting rights. Prior to settlement or forfeiture, any Restricted Stock Unit granted under the Plan may, at the discretion of the Board of Directors, carry with it a right to dividend equivalents. Such right entitles the holder to
be credited with an amount equal to all cash dividends paid on one Share while the Restricted Stock Unit is outstanding. Dividend equivalents may be converted into additional Restricted Stock Units. Settlement of dividend equivalents may be made in
the form of cash, in the form of Shares, or in a combination of both. Prior to distribution, any dividend equivalents that are not paid shall be subject to the same conditions and restrictions as the Restricted Stock Units to which they attach. 

(f)
Form and Time of Settlement of Restricted Stock Units. Settlement of vested Restricted
Stock Units may be made in the form of (i) cash, (ii) Shares or (iii) any combination of both, as determined by the Board of Directors. The actual number of Restricted Stock Units eligible for settlement may be larger or smaller than
the number included in the original award, based on predetermined performance factors. Vested Restricted Stock Units shall be settled in such manner and at such time(s) as specified in the Restricted Stock Unit Agreement. Until Restricted Stock
Units are settled, the number of Shares represented by such Restricted Stock Units shall be subject to adjustment pursuant to Section 9. 

(g) Death of Recipient. Any Restricted Stock Units that become distributable after the
Participant’s death shall be distributed to the Participant’s estate or to any person who has acquired such Restricted Stock Units directly from the recipient by beneficiary designation, bequest or inheritance. 

(h) Creditors’ Rights. A holder of Restricted Stock Units shall have no rights other than those of a general
creditor of the Company. Restricted Stock Units represent an unfunded and unsecured obligation of the Company, subject to the terms and conditions of the applicable Restricted Stock Unit Agreement. 

  
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 (i)
Modification, Extension and Assumption of Restricted Stock Units. Within the limitations of the Plan, the
Board of Directors may modify, extend or assume outstanding restricted stock units (whether granted by the Company or a different issuer) . The foregoing notwithstanding, no modification of a Restricted Stock Unit shall, without the consent of the
Participant, impair the Participant’s rights or increase the Participant’s obligations under such Restricted Stock Unit. 
 (j)
Restrictions on Transfer of Restricted Stock Units. A Restricted Stock Unit shall be transferable by the Participant only by
(i) a beneficiary designation, (ii) a will or (iii) the laws of descent and distribution, except as provided in the next sentence. In addition, if the Board of Directors so provides, in a Restricted Stock Unit Agreement or otherwise,
a Restricted Stock Unit shall also be transferable to the extent permitted by Rule 701 under the Securities Act. 
 SECTION 8. PAYMENT FOR SHARES.

 (a) General Rule. The entire Purchase Price or Exercise Price of Shares issued under the Plan shall be
payable in cash or cash equivalents at the time when such Shares are purchased, except as otherwise provided in this Section 8. In addition, the Board of Directors in its sole discretion may also permit payment through any of the methods
described in (b) through (g) below. 
 (b) Services Rendered. Shares may be awarded under the Plan in
consideration of services rendered to the Company, a Parent or a Subsidiary prior to the award. 
 (c)
Promissory Note. All or a portion of the Purchase Price or Exercise Price (as the case may be) of Shares issued under the Plan may be paid with a promissory note. The Shares shall be pledged as security for payment of the
principal amount of the promissory note and interest thereon. The interest rate payable under the terms of the promissory note shall not be less than the minimum rate (if any) required to avoid the imputation of additional interest under the Code.
Subject to the foregoing, the Board of Directors in its sole discretion shall specify the term, interest rate, recourse, amortization requirements (if any) and other provisions of such note. 

(d) Surrender of Stock. All or any part of the Exercise Price may be paid by surrendering, or at
testing to the ownership of, Shares that are already owned by the Optionee. Such Shares shall be surrendered to the Company in good form for transfer and shall be valued at their Fair Market Value as of the date when the Option is exercised. 

(e) Cashless Exercise. All or part of the Exercise Price and any with holding taxes may be paid pursuant to a
cashless exercise arrangement (whether through a securities broker or otherwise) established by the Company where by Shares subject to an Option are sold and all or part of the sale proceeds are delivered to the Company. 

  
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 (f) Net Exercise. An Option may permit exercise through a
“net exercise” arrangement pursuant to which the Company will reduce the number of Shares issued upon exercise by the largest whole number of Shares having an aggregate Fair Market Value (determined by the Board of Directors as of the
exercise date) that does not exceed the aggregate Exercise Price or the sum of the aggregate Exercise Price and any withholding taxes (with the Company accepting from the Optionee payment of cash or cash equivalents to satisfy any remaining balance
of the aggregate Exercise Price and, if applicable, any additional with holding taxes not satisfied through such reduction in Shares); provided that to the extent Shares subject to an Option are with held in this manner, the number of Shares
subject to the Option following the net exercise will be reduced by the sum of the number of Shares with held and the number of Shares delivered to the Optionee as a result of the exercise. 

(g) Other Forms of Payment. To the extent that an Award Agreement so provides,
the Purchase Price or Exercise Price of Shares issued under the Plan may be paid in any other form permitted by the Delaware General Corporation Law, as amended. 

SECTION 9. ADJUSTMENT OF SHARES. 
 (a)
General. In the event of a subdivision of the outstanding Stock, a declaration of a dividend payable in Shares, a combination or consolidation of the outstanding Stock into a lesser number of Shares, a reclassification, or any other increase
or decrease in the number of issued shares of Stock effected without receipt of consideration by the Company, proportionate adjustments shall automatically be made, as applicable, in each of (i) the number and kind of Shares available under
Section 4, (ii) the number and kind of Shares covered by each outstanding Option, Award of Restricted Stock Units and any outstanding and unexercised right to purchase Shares that has not yet expired pursuant to Section 5(b),
(iii) the Exercise Price under each outstanding Option and the Purchase Price applicable to any unexercised stock purchase right described in clause (ii) above, and (iv) any repurchase price that applies to Shares granted under the
Plan pursuant to the terms of a Company repurchase right under the applicable Award Agreement. In the event of a declaration of an extraordinary dividend payable in a form other than Shares in an amount that has a material effect on the Fair Market
Value of the Stock, a recapitalization, a spin-off, or a similar occurrence, the Board of Directors at its sole discretion may make appropriate adjustments in one or more of the items listed in clauses
(i) through (iv) above; provided, however, that the Board of Directors shall in any event make such adjustments as may be required by Section 25102(o) of the California Corporations Code to the extent the Company is relying on the
exemption afforded there under with respect to an Award. No fractional Shares shall be issued under the Plan as a result of an adjustment under this Section 9(a), al though the Board of Directors in its sole discretion may make a cash payment
in lieu of fractional Shares. 

  
 8 

 (b) Corporate Transactions. In the event that the Company
is a party to a merger or consolidation, or in the event of a sale of all or substantially all of the Company’s stock or assets, all Shares acquired under the Plan and all Awards outstanding on the effective date of the transaction shall be
treated in the manner described in the definitive transaction agreement (or, in the event the transaction does not entail a definitive agreement to which the Company is party, in the manner determined by the Board of Directors in its capacity as
administrator of the Plan, with such determination having final and binding effect on all parties), which agreement or determination need not treat all Awards (or all portions of an Award) in an identical manner. The treatment specified in the
transaction agreement or as determined by the Board of Directors may include (without limitation) one or more of the following with respect to each outstanding Award: 

(i) The Company, the surviving corporation or a parent there of may continue or assume the Award or substitute a comparable
award for the Award (including, but not limited to, an award to acquire the same consideration paid to the holders of Shares in the transaction). For avoidance of doubt, a comparable award need not be the same type of award as the Award for which it
is substituted, and, in the case of an Option, need not have the same tax-status (e.g., an NSO may be substituted for an ISO). 

(ii) The cancellation of the Award and a payment to the Participant with respect to each Share subject to the portion of the
Award that is vested as of the transaction date equal to the excess of (A) the value, as determined by the Board of Directors in its absolute discretion, of the property (including cash) received by the holder of a share of Stock as a result of
the transaction, over (if applicable) (B) the per-Share Exercise Price of the Award (such excess, the “Spread”). Such payment shall be made in the form of cash, cash equivalents, or securities
of the surviving corporation or its parent having a value equal to the Spread. In addition, any escrow, indemnification, holdback, earn-out or similar provisions in the transaction agreement may apply to such
payment to the same extent and in the same manner as such provisions apply to the holders of Stock. Receipt of the payment described in this Subsection (b)(ii) may be conditioned upon the Participant acknowledging such escrow, indemnification,
holdback, earn-out or other provisions on a form prescribed by the Company. If the Spread applicable to an Award is zero or a negative number, then the Award may be cancelled without making a payment to the Participant. 

(iii) Even if the Spread applicable to an Option is a positive number, the Option may be cancelled without the payment of any
consideration; provided that the Optionee shall be notified of such treatment and given an opportunity to exercise the Option (to the extent the Option is vested or becomes vested as of the effective date of the transaction) during a period of not
less than five (5) business days preceding the effective date of the transaction, unless (A) a shorter period is required to permit a timely closing of the transaction and (B) 

  
 9 

 such shorter period still offers the Optionee a reasonable opportunity to exercise the
Option. 
 (iv) In the case of an Option: (A) suspension of the Optionee’s right to exercise the Option during a limited
period of time preceding the closing of the transaction if such suspension is administratively necessary to facilitate the closing of the transaction and/or (B) termination of any right the Optionee has to exercise the Option prior tovesting in the
Shares subject to the Option (i.e.,“early exercise”),such that following the closing of the transaction the Option may only be exercised to the extent it is vested. 

For the avoidance of doubt, the Board of Directors has discretion to accelerate,in whole or part, the vesting and exercisability of an Award in connection
with a corporate transaction covered by this Section 9(b) . 
 (c)
Dissolution or Liquidation. To the extent not previously exercised or settled, Options, Restricted Stock Units and other rights to purchase Shares shall terminate immediately prior to the liquidation or
dissolution of the Company. 
 (d) Reservation of Rights. Except as provided in Section
7(e) or this Section 9, a Participant shall have no rights by reason of (i) any subdivision or consolidation of sharesof stock of any class, (ii) the payment of any dividend or (iii) any other increase or decrease in the number of shares of
stock of any class. Any issuance by the Company of shars of stock of any class, or securities convertible into shares of stock of any class, shall not affect, and no adjustmentby reason there of shall be made with respect to, the number or Exercise
Priceof Shares subject to an Award. The grant of an Award pursuant to the Plan shall not affectinany way the right or power of the Company to make adjustments,reclassifications,reorganizations or changes of its capital or business structure,to merge
or consolidate or to dissolve,liquidate,sell or transfer all or any part of its business or assets. 
 SECTION 10. MISCELLANEOUS PROVISIONS. 

(a) Securities Law Requirements. Shares shall not be issued under the Plan unless, in the
opinion of counsel acceptable to the Board of Directors, the issuance and delivery of such Shares complies with (or is exempt from) all applicable requirements of law, including (without limitation) the Securities Act, the rules and regulation
spromulgated the reunder,state securities laws and regulations, and the regulations of any stock exchange or other securities market on which the Company’s securities may then be traded. The Company shall not be liable for a failure to issue
Shares as a result of such requirements. Without limiting the foregoing, the Company may suspend the exercise of some or all outstanding Options for a period of up to 60 days in order to facilitate compliance with Securities Act Rule 701(e) . 

(b) No Retention Rights. Nothing in the Plan or in any right or A ward granted under the
Plan shall confer upon the Participant any right to continue in Service for any period of specific duration or interfere with or other wisere strictin any way the rights of the Company (or any Parent or Subsidiary employing or retaining the
Participant) or of the Participant, which rights are hereby expressly reserved by each, to terminate his or her Serviceat any time and for any reason, with or without cause. 

(c)Treatment as Compensation. Any compensation thatan individualearns or is deemed to earn
under this Plan shall not be considered a part of his or her compensation for purposes of calculating contributions, accruals or benefits under any other plan or program that is maintained or funded by the Company, a Parent or a Subsidiary. 

(d) Governing Law. The Plan and all awards, sales and grants under the Plan shall be governed by, and
construedin accordance with, the laws of the State of Delaware (exceptits choice-of-lawprovisions), as such laws are applied to contracts entered into and performed in
such State. 

  
 10 

 (e)
Conditions and Restrictions on Shares. Shares is sued under the Plan shall be subject to such forfeiture conditions, rights of repurchase, rights of first refusal, other
transfer restrictions and such other terms and conditions as the Board of Directors may determine. Such conditions and restrictions shall be set forth in the applicable Award Agreement and shall apply in addition to any restrictions at may apply to
holders of Shares generally. In addition, Shares issued under the Plan shall be subject to conditions and restrictions imposed either by applicable law or by Company policy, as adopted from time to time, designed to ensure compliance with applicable
law or laws with which the Company determines in its sole discretion to comply including in order to maintain any statutory, regulatory or tax advantage, which (for avoidance of doubt) need not be set forth in the applicable Award Agreement. 

(f) Tax Matters. 

(i) As a condition to the award, grant, issuance, vesting, purchase, exercise, settlement or transfer of any Award, or Shares
issued pursuant to any Award, granted under this Plan, the Participant shall make such arrangements as the Board of Directors may require or permit for the satisfaction of any federal, state, local or foreign with holding tax obligations that may
arise in connection with such event. 
 (ii) Unless otherwise expressly set forth in an Award Agreement, it in tended
that Awards shall be exempt from Code Section 409A, and any ambiguity in the terms of an Award Agreement and the Plan shall be interpreted consistently with this intent. To the extent an Award is not exempt from Code Section 409A (any such award, a
“409A Award ”), any ambiguity in the terms of such Award and the Plan shall be interpreted in a manner that to the maximum extent permissible supports the Award’s compliance with the requirements of that statute.
Notwithstanding anything to the contrary permitted under the Plan, in no event shall a modification of an Award not already subject to Code Section 409A, or any subsequent action taken with respect to such Award, be given effect if such modification
or action would cause the Award to become subject to Code Section 409A unless the parties explicitly acknowledge and consent to the modification or action as one having that effect. A 409A Award shall be subject to such additional rules and
requirements as specified by the Board of Directors from time to time in order for it to comply with the requirements of Code Section 409A. In this regard, if any amount under a 409A Award is payable upon a “separation from service” to an
individual who is considered a “specified employee” (as each term is defined under Code Section 409A), then no such payment shall be made prior to the date that is the earlier of (i) six months and one day after the Participant’s
separation from service or (ii) the Participant’s death, but only to the extent such delay is necessary to prevent such payment from being subject to Section 409A(a)(1). In addition, if a transaction subject to Section 9(b) constitutes a
payment event with respect to any 409A Award, then the transaction with respect to such award must also constitute a “change in control event” as defined in Treasury Regulation
Section 1.409A-3(i)(5) to the extent required by Code Section 409A. 

  
 11 

 (iii) Neither the Company nor any member of the Board of Directorsshallhave
any liabilityto a Participantin the event an Award held by the Participant fails to achieve its in tended characterization under applicabletax law. 

SECTION 11. DURATION AND AMENDMENTS; STOCKHOLDER APPROVAL. 

(a) Term of the Plan. The Plan, as setforthherein,shallbecome effective
on the date of it sadoptionby the Board of Directors,subject to approval of the Company’s stockholders under Subsection(d) below. The Plan shall terminate automatically10 yearsafter the later of (i) the date when the Board of Directors adopted
the Plan or (ii) the date when the Board of Directors approved the most recentincreasein the number of Shares reserved under Section 4 that was also approved by the Company’s stockholders. The Plan may be terminatedon any earlier date
pursuant to Subsection (b) below. 
 (b)
Right to Amend or Terminate the Plan. Subjectto Subsection(d) below, the Board of Directors may amend, suspend or terminate the
Plan at any time and for any reason. 
 (c)
Effect of Amendment or Termination. No Sharesshallbe issuedor soldand no Award grantedunder thePlan after the termination there of,except upon exercise or settlement of
an Award granted under the Plan priorto such termination. Except as expressly provided in Section6(k) above, the terminationof the Plan, or any amendment thereof,shall not affect any Share previously issued or any Award previously granted under the
Plan. 
 (d) Stockholder Approval. To the extentrequired by applicable law, the Plan will be subject
to approval of the Company’s stockholders within12 months of its adoptiondate. An amendment of the Plan will be subject to the approval of the Company’s stock holders only to the extent required by applicable laws, regulations or rules.

 SECTION 12. DEFINITIONS. 
 (a)
“Award ” means any award granted under the Plan, including as an Option, an award of Restricted Stock Units or the grant or sale of Shares pursuant to Section 5 of the Plan. 

(b) “Award Agreement” means a Restricted Stock Unit Agreement, Stock Grant Agreement, Stock Option Agreement or Stock
Purchase Agreement or such other agreement evidencing an Award under the Plan. 
 (c) “Board of Directors” means the Board
of Directors of the Company, as constituted from time to time. 
 (d) “Code” means the Internal Revenue Code of 1986, as
amended. 
 (e) “Committee” means a committee of the Board of Directors, as described in Section 2(a). 

  
 12 

 (f) “Company” means Pyxis Oncology, Inc., a Delaware corporation. 

(g) “Consultant” means a person, excluding Employees and Outside Directors, who performs bona fide services for the Company,
a Parent or a Subsidiary as a consultant or advisor and who qualifies as a consultant or advisor under Rule 701(c)(1) of the Securities Act or under Instruction A.1.(a)(1) of Form S-8 under the
Securities Act. 
 (h) “Date of Grant” means the date of grant specified in the Award Agreement, which date shall be
the later of (i) the date on which the Board of Directors resolved to grant the Award or (ii) the first day of the Participant’s Service. 

(i) “Disability” means that the Optionee is unable to engage in any substantial gainful activity by reason of any medically
determinable physical or mental impairment. 
 (j) “Employee” means any individual who is a
common-law employee of the Company, a Parent or a Subsidiary. 
 (k) “Exchange Act”
means the Securities Exchange Act of 1934, as amended. 
 (l) “Exercise Price” means the amount for which one Share
may be purchased upon exercise of an Option, as specified by the Board of Directors in the applicable Stock Option Agreement. 
 (m)
“Fair Market Value” means the fair market value of a Share, as determined by the Board of Directors in good faith. Such determination shall be conclusive and binding on all persons. 

(n) “Grantee” means a person to whom the Board of Directors has awarded Shares under the Plan. 

  
 13 

 (o) “ISO” means an Option that qualifies as an incentive stock option as
described in Code Section 422(b). Notwithstanding its designation as an ISO, an Option that does not qualify as an ISO under applicable law shall be treated for all purposes as an NSO. 

(p) “NSO” means an Option that does not qualify as an incentive stock option as described in Code Section 422(b) or
423(b). 
 (q) “Option” means an ISO or NSO granted under the Plan and entitling the holder to purchase Shares. 

(r) “Optionee” means a person who holds an Option. 

(s) “Outside Director” means a member of the Board of Directors who is not an Employee. 

(t) “Parent” means any corporation (other than the Company) in an unbroken chain of corporation sending with the Company, if
each of the corporations other than the Company owns stock possessing 50% or more of the total combined voting power of all classes of stock in one of the other corporations in such chain. A corporation that attains the status of a Parent on a date
after the adoption of the Plan shall be considered a Parent commencing as of such date. 
 (u) “Participant” means the
holder of an outstanding Award. 
 (v) “Plan” means this Pyxis Oncology, Inc. 2019 Stock Plan. 

(w) “Purchase Price” means the consideration for which one Share may be acquired under the Plan (other than upon
exercise of an Option), as specified by the Board of Directors. 
 (x) “Purchaser” means a person to whom the Board of
Directors has offered the right to purchase Shares under the Plan (other than upon exercise of an Option) . 
 (y) “Restricted Stock
Unit” means a bookkeeping entry representing the equivalent of one Share, as awarded under the Plan. 
 (z) “Restricted
Stock Unit Agreement” means the agreement between the Company and the recipient of a Restricted Stock Unit that contains the terms, conditions and restrictions pertaining to such Restricted Stock Unit. 

(aa) “Securities Act” means the Securities Act of 1933, as amended. 

(bb) “Service” means service as an Employee, Outside Director or Consultant. In case of any dispute as to whether and when
Service has terminated, the Board of Directors shall have sole discretion to determine whether such termination has occurred and the effective date of such termination. 

  
 14 

 (cc) “Share” means one share of Stock, as adjusted in accordance with
Section 9 (if applicable). 
 (dd) “Stock” means the Common Stock of the Company. 

(ee) “Stock Grant Agreement” means the agreement between the Company and a Grantee who is awarded Shares under the
Plan that contains the terms, conditions and restrictions pertaining to the award of such Shares. 
 (ff) “Stock Option
Agreement” means the agreement between the Company and an Optionee that contains the terms, conditions and restrictions pertaining to the Optionee’s Option. 

(gg) “Stock Purchase Agreement” means the agreement between the Company and a Purchaser who purchases Shares under the
Plan that contains the terms, conditions and restrictions pertaining to the purchase of such Shares. 
 (hh)
“Subsidiary” means any corporation (other than the Company) in an unbroken chain of corporations beginning with the Company, if each of the corporations other than the last corporation in the unbroken chain owns stock possessing 50%
or more of the total combined voting power of all classes of stock in one of the other corporations in such chain. A corporation that attains the status of a Subsidiary on a date after the adoption of the Plan shall be considered a Subsidiary
commencing as of such date. 

  
 15

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