Document:

Separation Agreement and Release

 Exhibit 10.1 
 SEPARATION AGREEMENT AND RELEASE 
 This Separation Agreement and Release (this
“Agreement”) is entered into by and between Richard E. Gammans, Ph.D., (“Gammans”) and MediciNova, Inc. a Delaware corporation (the “Company”), with regard to the following: 
 A. Whereas, Gammans served in various capacities as an officer and employee of the Company, most recently as Chief Development Officer of the Company,
until June 12, 2009 (the “Separation Date”); and 
 B. Whereas, Gammans and the Company are parties to that certain
Executive Employment Agreement, dated as of June 14, 2004 (the “Employment Agreement”), providing for certain rights and responsibilities on the part of Gammans and the Company. 
 NOW, THEREFORE, the parties hereto agree as follows: 
 1. Severance Payments. In consideration of the covenants and promises contained in this Agreement and as full and final satisfaction of all obligations the Company owes to Gammans under the Employment Agreement
or otherwise, the Company shall pay to Gammans, or on Gammans’ behalf, as severance payments the following amounts, less appropriate deductions and withholdings: 
 (a) Provided Gammans executes this Agreement and after the Effective Date (as defined below), compensation representing the amount Gammans would have received as salary for June 12, 2009 through March 12,
2010 under the Employment Agreement in the aggregate gross amount of $292,263.75, less income and employment taxes required in the judgment of the Company to be deducted or withheld, to be paid on the date of the Company’s first regularly
scheduled payroll date following the Effective Date; 
 (b) Provided Gammans timely elects continuation coverage pursuant to the provisions
relating to the Consolidated Omnibus Budget Reconciliation Act of 1985 (“COBRA”) of the Company’s group health plan, and provided that Gammans executes this Agreement, after the Effective Date, the Company will pay the
applicable COBRA premium to continue medical benefits for Gammans and his dependents in the same manner that such benefits are in effect as of the Separation Date for the nine (9) month period of June 12, 2009 through March 12, 2010
(thereafter Gammans shall, to the extent he remains eligible for such benefits, be responsible for paying the applicable COBRA premium), with the exception that the Company’s payment of premiums pursuant to this Section and such benefits will
be discontinued if and when Gammans obtains medical benefits pursuant to a group health plan of another employer; and 
 (c) Provided Gammans
executes this Agreement, and on the date of the Company’s first regularly scheduled payroll date following the Effective Date, a lump sum payment of aggregate of $4,000.00 to help defray certain lease and relocation costs. 
 2. Release. In consideration of the above described payments and benefits to which Gammans would not otherwise be entitled, Gammans does hereby
unconditionally, irrevocably and absolutely release and discharge the Company, and all related subsidiary entities, and their affiliates, directors, officers, employees, agents, attorneys, stockholders, insurers, successors and/or assigns, from

 
any and all liability, claims, demands, causes of action, or suits of any type, whether in law and/or in equity, known or unknown, related directly or
indirectly or in any way connected with any transaction, affairs or occurrences between them to date, including, but not limited to, Gammans’ employment with the Company and the termination of said employment. This release shall include, but
not be limited to, a release of claims arising under any state or federal statute or common law regulating or affecting employment, including Title VII of the Civil Rights Act of 1964, the Age Discrimination in Employment Act of 1967, the Americans
with Disabilities Act of 1990, the Equal Pay Act of 1963, the Fair Labor Standards Act of 1938, the California Labor Code, the California Fair Employment and Housing Act and any other statutory or common law provision relating to or affecting
Gammans’ employment by the Company, each as amended through the date hereof, including any federal or state statutory provision covering any age discrimination in any form by the Company against Gammans, except any claim for worker’s
compensation. Nothing herein is intended to affect any right that Gammans may have, if any, to defense and/or indemnification by the Company under the Company’s Amended and Restated Bylaws dated February 4, 2005 or Gammans’
Indemnification Agreement dated February 4, 2005 in the event that Gammans is sued for acts committed in the course and scope of his employment for the Company. 
 3. Claims. In further consideration of the above described payments and benefits, Gammans irrevocably and absolutely agrees that he will not prosecute nor allow to be prosecuted on his behalf in any
administrative agency, whether federal or state, or in any court, whether federal or state, any claim or demand of any type related to the matter release above. It is the intention of the parties that, with the execution of this Agreement, the
Company and all related entities, and their affiliates, officers, directors, employees, agents, attorneys, stockholders, insurers, successors and/or assigns will be absolutely, unconditionally and forever discharged of and from all obligations to or
on behalf of Gammans related in any way to the matter discharged herein. Gammans represents that he has not filed any complaint, charges or lawsuits against the Company and all related subsidiary entities (including their affiliates, officers,
directors, and employees) with any governmental agency or any court. 
 4. Unknown Claims. Gammans understands and agrees that this
release extends to all claims of every nature, known or unknown, suspected or unsuspected, past or present, and that any and all rights granted to Gammans under section 1542 of the California Civil Code or any analogous federal law or regulation are
hereby expressly waived. Said section 1542 of the California Civil Code reads as follows: 
 “A general release does not extend to claims
which the creditor does not know of or suspect to exist in his or her favor at the time of executing the release, which if known by him or her must have materially affected his or her settlement with the debtor.” 
 Notwithstanding any provisions of this Agreement to the contrary, Gammans does not waive any right or release any claim against the Company which claim
or right arises from the Company failing to perform its undertakings as set forth in this Agreement and/or may arise after the date Gammans executes this release including Gammans’ rights, if any, pursuant to COBRA. 
  

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 5. Effect on Previous or Existing Agreements. This Agreement is intended to resolve any and all
issues between the Company and Gammans, including any and all claims for wages, severance pay, compensation, benefits or other aspects of the employment relationship between the Company and Gammans. Except as set forth in this Section 5, this
Agreement shall supersede and extinguish all prior employment agreements, express or implied, verbal or written, between the Company and Gammans; provided, however, that this Agreement shall have no effect on (i) that certain Proprietary
Information and Inventions Agreement, dated as of June 14, 2004, (ii) any stock option agreements and (iii) with respect solely to acts committed in the course and scope of his employment for the Company, Gammans’ Indemnification
Agreement dated February 4, 2005. This Agreement shall also not in any way supersede or affect any obligation of Gammans, contractual or otherwise, with respect to the disclosure, use or protection of any proprietary or confidential information
of the Company, including any trade secrets, or with respect to the disclosure and assignment of inventions made or conceived by Gammans during his employment. All previous written agreements and obligations imposed by any contract relating to the
intellectual property of the Company or its subsidiaries or affiliated entities shall remain in full force and effect and survive the execution of this Agreement. 
 6. Return of Company Property. Gammans shall immediately return any company property in his possession, including all company-owned computers and cellular telephones. All such property shall be returned in good
working condition and order. 
 7. Non-Disparagement. Gammans and the Company each agree that he or it shall not make any oral or
written statements or knowingly make any comments, whether privately or publicly, which in fact or by implication tend to disparage the other or are inimical to the interests of the other. In the event the Company is contacted for employment
references regarding Gammans, the Company shall provide only the dates of employment and positions held. 
 8. Binding Effect. Gammans
further declares and represents that no promise, inducement or agreement not expressed herein has been made to him and that this Agreement contains the entire agreement between the parties relating to the subject matter hereof. This Agreement may be
modified only by a writing signed by both Gammans and the Company. 
 9. Successors. The Company and Gammans understand and expressly
agree that this Agreement shall bind and benefit the heirs, partners, successors, employees, directors, stockholders, officers, attorneys, affiliates, predecessors, representatives and assigns of the Company and Gammans. 
 10. Interpretation. The validity, interpretation, and performance of this Agreement shall be construed and interpreted according to the laws of
the State of California. This Agreement shall not be interpreted for or against either party hereto on the ground that such party drafted or caused this Agreement to be drafted. If any provision of this Agreement, or part thereof, is held invalid,
void or voidable as against the public policy or otherwise, the invalidity shall not affect other provisions, or parts thereof, which may be given effect without the invalid provision or part. To this extent, the provisions, and parts thereof, of
this Agreement are declared to be severable. 
  

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 11. Resolution of Employment Related Disputes. Except as prohibited by law, any dispute arising
from any aspect of the employment relationship with the Company shall be resolved through final and binding arbitration in San Diego, California. All employment disputes of any nature shall be covered by this Agreement, except as prohibited by law.
The law applicable to any controversy to be arbitrated shall be the law of the state of California or applicable federal law, except that the Federal Arbitration Act shall apply to the issue of arbitrability. The arbitration shall be conducted by a
single neutral arbitrator selected by the parties from a list maintained and provided by the American Arbitration Association (“AAA”) or Judicial Arbitration and Mediation Services (“JAMS”). Gammans shall not be
required to pay any administrative fees of the AAA or JAMS. Any administrative fees or arbitrator’s fees will be paid by the Company. The arbitrator shall have no power to award costs and attorneys’ fees except as provided by statute or by
separate written agreement between the parties. Notwithstanding the foregoing, nothing herein shall preclude either party from seeking, on a temporary basis, relief from a court in a dispute involving the ownership, use or disclosure of confidential
or proprietary information or trade secrets, until such time as an arbitrator can be selected. Once selected, the arbitrator shall have the power to continue, vacate, modify or amend any temporary or interim relief, and shall have the power to
resolve the dispute. In the event that any aspect of this arbitration provision is found unenforceable by a court of competent jurisdiction, the remainder of the arbitration provision shall be severed from the invalid portion and the remaining
portion shall be given full effect according to its terms. This arbitration provision shall supersede any and all prior agreements between the Company and Gammans on the subject of arbitration of employment-related claims. 
 12. No Admissions. It is agreed that this Agreement is not an admission of any liability or fault whatsoever by either the Company or Gammans.

 13. Execution and Revocation Periods. Gammans acknowledges and agrees that the severance payments set forth in Section 1
constitute consideration beyond that which, but for the mutual covenants set forth in this Agreement, the Company would be obligated to provide, or Gammans otherwise would be entitled to receive. Gammans acknowledges that he has twenty-one
(21) days after actual receipt of this Agreement in which to consider and execute this Agreement. Changes to this Agreement, whether material or immaterial, do not restart the 21-day period. Gammans agrees and acknowledges that if he chooses to
sign this Agreement before 21 days after he received it, that he has done so voluntarily. Furthermore, Gammans has a period of seven (7) days following the execution of this Agreement in which to revoke this Agreement. Accordingly, this
Agreement will not become effective or enforceable (and the severance payments will not be paid or recognized) until such 7-day revocation period has expired and the Separation Date has passed (the “Effective Date”). 
 14. Counsel. Gammans acknowledges that he fully understands his right to discuss this Agreement with independent counsel of his choice, that he is
encouraged to do so, that he has carefully read and fully understands this entire Agreement and that he is voluntarily entering into this Agreement. 
 15. Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 
  

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 16. Acknowledgments Related to Compensation and Benefits. Gammans acknowledges that he is not
entitled to receive any wages, benefits, bonuses, commissions or compensation, however characterized, other than the amounts provided for in Section 1 above, which he will receive provided that he will have returned to the Company an executed
copy of the Agreement after the Effective Date of Agreement. 
 17. Notices. Any notices required or permitted hereunder shall be
given to the appropriate party at the address specified at below (or at such other address as the party shall specify in writing). Such notice shall be deemed given either (a) upon personal delivery, (b) one (1) business day after
being sent by overnight delivery service or (c) on the day of transmission by facsimile, provided that the notifying party confirms receipt of such transmission with the other party by telephone. 
  

			
	If to MediciNova:	  	MediciNova, Inc.
		  	4350 La Jolla Village Drive, Suite 950
		  	San Diego, CA 92122
		  	Attention: Shintaro Asako
		  	Telephone: 858-373-1500
		  	Fax: 858-373-7000
		  	Email: asako@medicinova.com
		
	If to Gammans:	  	Richard E. Gammans, Ph.D.

 [SIGNATURE PAGE FOLLOWS] 
  

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 The undersigned have executed this Agreement as of June 26, 2009 at San Diego, California.

  

							
		 		 	MEDICINOVA, INC.
				
	 /s/ Richard E. Gammans
	 		 	By:	 	 /s/ Shintaro Asako

	Richard E. Gammans, Ph.D.	 		 	Name:	 	Shintaro Asako
		 		 	Title:	 	Chief Financial OfficerSixth Supplemental Indenture

 Exhibit 4.13 
  
  
 TANGER PROPERTIES LIMITED PARTNERSHIP 
 as Issuer 
 TANGER FACTORY OUTLET CENTERS, INC.

 as Guarantor 
 and 

U.S. BANK NATIONAL ASSOCIATION 
 as Trustee

 SIXTH SUPPLEMENTAL INDENTURE 
 Dated as of July 2, 2009 

 SIXTH SUPPLEMENTAL INDENTURE, dated as of July 2, 2009 (the “Sixth Supplemental
Indenture”), by and among TANGER PROPERTIES LIMITED PARTNERSHIP, a North Carolina limited partnership (the “Issuer”), TANGER FACTORY OUTLET CENTERS INC., a North Carolina corporation (the “Guarantor”), and
U.S. BANK NATIONAL ASSOCIATION (as successor in interest to State Street Bank and Trust Company), a national banking association having a corporate trust office at 100 Wall Street, Suite 1600, New York, New York 10005, as successor trustee under the
Original Indenture (as defined below) (the “Trustee”). 
 RECITALS 
 WHEREAS, the Issuer executed and delivered the Indenture (the “Original Indenture”), dated as of March 1, 1996, to the Trustee to
issue from time to time for its lawful purposes debt securities evidencing the Issuer’s senior unsecured Indebtedness. 
 WHEREAS,
Section 901(11) of the Original Indenture provides that the Issuer, Guarantor and Trustee may enter into a supplemental indenture without the consent of Holders of Securities or Coupons to amend or supplement any provision contained in the
Original Indenture or in any supplemental indenture, provided that no such amendment or supplement shall materially adversely affect the interests of the Holders of any Securities then Outstanding. 
 WHEREAS, the Sixth Supplemental Indenture will not affect the interests of the Holders of any Securities presently Outstanding because the Amendments
contained in the Sixth Supplemental Indenture will apply only to Series of Securities issued pursuant to the Original Indenture following the date hereof. 
 WHEREAS, the Issuer and the Guarantor desire, and have requested, the Trustee to join with it in entering into the Sixth Supplemental Indenture for the purpose of amending the Indenture in certain respects as
permitted by Section 901(11) of the Original Indenture. 
 WHEREAS, the execution and delivery of this Sixth Supplemental Indenture has
been authorized by the Board of Trustees of Tanger GP Trust, the sole general partner of the Issuer, and the Board of Directors of the Guarantor. 
 WHEREAS, the consent of Holders to the execution and delivery of this Sixth Supplemental Indenture is not required, and all other actions required to be taken under the Original Indenture with respect to this Sixth Supplemental Indenture
have been taken. 
 NOW, THEREFORE IT IS AGREED: 
 ARTICLE 1 
 DEFINITIONS 
 Section 1.01 Relation to Original Indenture and Supplemental Indentures 
 (a) This Sixth Supplemental Indenture shall constitute an integral part of the Original Indenture. 
 Section 1.02 Definitions. For all purposes of this Sixth Supplemental Indenture, except as otherwise expressly provided for or unless the context
otherwise requires: 
 (a) Capitalized terms used but not defined herein shall have the respective meanings assigned to them in the Original
Indenture; 
 (b) Terms defined both herein and in the Original Indenture shall have the meanings assigned to them herein; 

 (c) All references herein to Articles and Sections, unless otherwise specified, refer to the
corresponding Articles and Sections of this Sixth Supplemental Indenture; and 
 (d) All other terms used in this Sixth Supplemental
Indenture, which are defined in the Trust Indenture Act or which are by reference therein defined in the Securities Act (except as herein otherwise expressly provided or unless the context otherwise requires), shall have the meanings assigned to
such terms in the Trust Indenture Act and in the Securities Act as in force at the date of the execution of this Sixth Supplemental Indenture. The words “herein,” “hereof,” “hereunder,” and words of similar import refer
to this Sixth Supplemental Indenture as a whole and not to any particular Article, Section or other Subdivision. The terms defined in this Article include the plural as well as the singular. 
 ARTICLE 2 
 AMENDMENTS TO INDENTURE 
 For all series of Securities issued pursuant to the Original Indenture following the date hereof, the Original Indenture is hereby amended as follows:

 Section 2.01 Amendment to Section 1005. Section 1005 of the Original Indenture shall be deleted, and amended and restated
in its entirety to read as follows: 
 “Section 1005. Maintenance of Properties. 
 Each of the Issuer and the General Partner will be required to cause all of its material properties used or useful in the conduct of its
business or the business of any Subsidiary to be maintained and kept in good condition, repair and working order and supplied with all necessary equipment and will cause to be made all necessary repairs, renewals, replacements, betterments and
improvements thereof, all as in the judgment of the Issuer and the General Partner may be necessary so that the business carried on in connection therewith may be properly and advantageously conducted at all times; provided, however , that the
Issuer, the General Partner and any Subsidiary shall not be prevented from closing, selling or otherwise disposing for value their respective properties except as otherwise provided in Article Eight.” 
 Section 2.02 Amendment to Section 1006. Section 1006 of the Original Indenture shall be deleted, and amended and restated in its
entirety to read as follows: 
 “Section 1006. Insurance. 
 The Issuer and the General Partner will, and will cause each of their respective Subsidiaries to, keep all of its insurable properties
insured against loss or damage at least equal to their then full insurable value with insurers of recognized responsibility.” 
 Section
2.03 Amendment to Section 1011. Section 1011 of the Original Indenture shall be deleted, and amended and restated in its entirety to read as follows: 
 “Section 1011. Restrictions on Dividends and Other Distributions. 
 The Issuer will not make any distribution, by reduction of capital or otherwise (other than distributions payable in securities
evidencing interests in the Issuer’s capital 

  

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for the purpose of acquiring interests in real property or otherwise) unless, immediately after giving pro forma effect to such distribution, (a) no
default hereunder shall have occurred or be continuing; and (b) the aggregate sum of all distributions made after the date hereof shall not exceed the sum of (i)95% of the aggregate cumulative Funds From Operations of the Issuer accrued on a
cumulative basis from the date hereof until the end of the last fiscal quarter prior to the contemplated payment, and (ii) the aggregate Net Cash Proceeds received by the Issuer after the date hereof from the issuance and sale of Capital Stock
of the Issuer or the General Partner to the extent such proceeds are contributed to the Issuer; provided, however, that the foregoing limitation in clauses (a) and (b) shall not apply to any distribution or other action which is necessary
to maintain the General Partner’s status as a REIT under the Code, if the aggregate principal amount of all outstanding Indebtedness of the General Partner and the Issuer on a consolidated basis at such time is less than 60% of Adjusted Total
Assets.” 
 ARTICLE 3 
 MISCELLANEOUS PROVISIONS 
 Section 3.01 Ratification of Original Indenture. Except as expressly modified or amended
hereby, the Original Indenture, as modified by any supplemental indenture entered into prior to the date hereof continues in full force and effect and is in all respects confirmed, ratified and preserved. 
 Section 3.02 Provisions Binding on Issuer’s Successors. All the covenants, stipulations, promises and agreements of the Issuer contained in
this Sixth Supplemental Indenture shall bind its successors and assigns whether so expressed or not. 
 Section 3.03 Official Acts by
Successor Corporation. Any act or proceeding by any provision of this Sixth Supplemental Indenture authorized or required to be done or performed by any board, committee, trustee or officer of the Issuer shall and may be done and performed with
like force and effect by the like board, committee, trustee or officer of any corporation, trust or other entity that shall at the time be the lawful sole successor of the Issuer. 
 Section 3.04 Governing Law. THIS SIXTH SUPPLEMENTAL INDENTURE SHALL BE DEEMED TO BE A CONTRACT MADE UNDER THE LAWS OF THE STATE OF NEW YORK, AND
FOR ALL PURPOSES SHALL BE CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 
 Section 3.05 Evidence of Compliance with
Conditions Precedent; Certificates and Opinions of Counsel to Trustee. Upon any application or demand by the Issuer to the Trustee to take any action under any of the provisions of the Original Indenture or this Sixth Supplemental Indenture, the
Issuer shall furnish to the Trustee an Officers’ Certificate stating that all conditions precedent, if any, provided for in the Original Indenture or this Sixth Supplemental Indenture relating to the proposed action have been complied with, and
an Opinion of Counsel stating that, in the opinion of such counsel, all such conditions precedent have been complied with. 
 Each
certificate or opinion provided for by or on behalf of the Issuer in the Original Indenture or this Sixth Supplemental Indenture and delivered to the Trustee with respect to compliance with a condition or covenant provided for in the Original
Indenture or this Sixth Supplemental Indenture shall include (i) a statement that the person making such certificate or opinion has read such covenant or condition; (ii) a brief statement as to the nature and scope of the examination or
investigation upon which the statement or opinion contained in such certificate or opinion is based; (iii) a statement that, in the 

  

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opinion of such person, he has made such examination or investigation as is necessary to enable him to express an informed opinion as to whether or not such
covenant or condition has been complied with; and (iv) a statement as to whether or not, in the opinion of such person, such condition or covenant has been complied with. 
 Section 3.06 Headings, Etc. The titles and headings of the articles and sections of this Sixth Supplemental Indenture have been inserted for
convenience of reference only, are not to be considered a part hereof, and shall in no way modify or restrict any of the terms or provisions hereof. 
 Section 3.07 Execution in Counterparts. This Sixth Supplemental Indenture may be executed in any number of counterparts, each of which shall be an original, but such counterparts shall together constitute but
one and the same instrument. 
 Section 3.08 Trustee. The Trustee makes no representations as to the validity or sufficiency of this
Sixth Supplemental Indenture. The statements and recitals herein are deemed to be those of the Issuer and not of the Trustee. 
 Section 3.09
Further Instruments and Acts. Upon request of the Trustee, the Issuer will execute and deliver such further instruments and do such further acts as may be reasonably necessary or proper to carry out more effectively the purposes of the
Original Indenture or this Sixth Supplemental Indenture. 
 Section 3.10 Waiver of Jury Trial. EACH OF THE ISSUER AND THE TRUSTEE
HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THE ORIGINAL INDENTURE OR THIS SIXTH SUPPLEMENTAL INDENTURE, THE NOTES OR THE
TRANSACTION CONTEMPLATED HEREBY. 
 Section 3.11 Force Majeure. In no event shall the Trustee be responsible or liable for any failure
or delay in the performance of its obligations hereunder arising out of or caused by, directly or indirectly, forces beyond its control, including, without limitation, strikes, work stoppages, accidents, acts of war or terrorism, civil or military
disturbances, nuclear or natural catastrophes or acts of God, and interruptions, loss or malfunctions of utilities, communications or computer (software and hardware) services; it being understood that the Trustee shall use reasonable efforts which
are consistent with accepted practices in the banking industry to resume performance as soon as practicable under the circumstances. 
  

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 IN WITNESS WHEREOF, the parties hereto have caused this Sixth Supplemental Indenture to be duly executed
as of the date first written above. 
  

			
	 Very truly yours,
 TANGER FACTORY OUTLET
CENTERS, INC.

		
	By:	 	/s/ Frank C. Marchisello, Jr.
		 	Name: Frank C. Marchisello, Jr.
		 	Title:   Executive Vice President, Chief Financial             Officer and Secretary

  

			
	 TANGER PROPERTIES LIMITED PARTNERSHIP
 By:
Tanger GP Trust, its general partner

		
	By:	 	/s/ Frank C. Marchisello, Jr.
		 	Name: Frank C. Marchisello, Jr.
		 	 Title:   Vice President, Treasurer and
             Assistant Secretary

 [SEAL] 
 Attest: 
  

			
		
	By:	 	/s/ Virginia R. Summerell
		 	Name: Virginia R. Summerell
		 	Title:    Secretary

  

			
	 U.S. BANK NATIONAL ASSOCIATION,
     as Trustee, as aforesaid

		
	By:	 	/s/ Carolina D. Altomare
		 	Name: Carolina D. Altomare
		 	Title:   Vice President

 Attest: 
  

			
		
	By:	 	/s/ Andrew Sinasky
		 	Name: Andrew Sinasky
		 	Title:   Vice President

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