Document:

EX-10.43

[Anadys Logo]

September 6, 2006

James T. Glover, CPA

[address]

[address]

Dear Jim,

I am very pleased to confirm the offer of employment made to you by Anadys Pharmaceuticals, Inc.
for the position of Senior Vice President, Operations and Chief Financial Officer, reporting to the
Company’s CEO. We anticipate your hire date to be no later than September 25, 2006. As we
discussed, the details of this offer are as follows:

	 	 	 
	BASE SALARY:

	 	You will receive a base salary of $11,875.00 paid

semi-monthly in accordance with the normal Anadys

payroll cycle, which if annualized, amounts to

$285,000 per year.
	 
	 	 
	STOCK OPTIONS:

	 	Upon commencement of your employment with Anadys and

subject to the approval of the Board of Directors or

Compensation Committee, you will be eligible for an

initial stock option grant allowing you to purchase

175,000 shares of Anadys common stock at a price

equal to the closing price of the stock one trading

day prior to your hire date. This stock option will

vest over a four-year period and will be subject to

the terms and conditions set forth in the Anadys 2004

Equity Incentive Plan (the “Plan”). You will be

provided full details of the Plan once you begin

employment.
	 
	 	 
	SIGN-ON BONUS/

RELOCATION:

	 	

As a further incentive for you to join Anadys and to

assist you in your move to San Diego, you will be

given a one time sign-on bonus/relocation assistance

of $65,000, less applicable taxes, in accordance with

Company policy. Monies which you do not utilize

towards the relocation up to the stated gross amount

of $65,000 will be given to you (less applicable

taxes) as a one-time sign on bonus. If you

voluntarily choose to terminate your employment with

Anadys within one year of your hire date, you will be

required to reimburse Anadys for a pro rata portion

of this sign-on bonus/relocation assistance, due and

payable immediately.
	 
	 	 
	BONUS:

	 	You will be eligible to receive an annual

discretionary bonus of between 0 — 40% of your then

current annual base salary, contingent upon your own

and the Company’s performance.
	 
	 	 
	BENEFITS:

	 	You will be eligible for group benefits for yourself

and your eligible dependents, effective the first day

of the month following your date of hire, subject to

the terms and conditions of the relevant Company

insurance plan. Basic benefits currently include

comprehensive health insurance; dental insurance, and

vision care insurance. In addition, you will be

eligible for term life insurance and long-term

disability insurance for yourself only. You will be

eligible to participate in the Anadys 401K plan as

well as the Anadys ESPP (Employee Stock Purchase

Plan), all in accordance with Company policy. You

will also accrue a pro-rata share of fifteen days of

paid vacation per year, and be eligible for paid

holidays, all in accordance with Company policy.

Effective on the first day of the month following your hire date, you will be
eligible to participate in the Anadys 401(k) Retirement Savings Plan.

	 	 	 
	SEVERANCE/CHANGE

IN

CONTROL:

	 	

You will be provided with a Severance and Change in

Control Agreement (the “Agreement”), which will provide

that (i) in the event that your employment with the

Company is terminated by the Company without Cause (as

defined in the Agreement ) or for Good Reason (as defined

in the Agreement) within the sixty (60) day period

immediately preceding or the twelve (12) month period

immediately following a Change in Control (as defined in

the Agreement) of the Company, then upon your delivery to

the Company of an effective Waiver and Release (in the

form attached to the Agreement), you shall be entitled

to: (a) the equivalent of nine (9) months of your annual

base salary in effect at the time of termination, less

standard deductions and withholdings, and (b) accelerated

vesting of all unvested shares subject to any outstanding

stock options then held by you, such that all shares

shall be vested and fully exercisable as of the date of

your termination; and (ii) in the event that there is not

a Change in Control (as defined in the Agreement) and

your employment with the Company is terminated by the

Company without Cause (as defined in the Agreement)

within the twelve (12) month period immediately following

your hire date, then upon your delivery to the Company of

an effective Waiver and Release (in the form attached to

the Agreement), you shall be entitled to the equivalent

of nine (9) months of your annual base salary in effect

at the time of termination, less standard deductions and

withholdings.
	 
	 	 
	EMPLOYMENT

AT WILL:

	 	

Anadys is an at-will employer and as such your employment

must be entered into voluntarily and for no specified

period. As a result, you are free to resign or the

company may terminate your employment at any time, for

any reason, with or without cause. No one other than the

President and CEO has the authority to alter this

employment relationship, either verbally or in writing.

Anadys Pharmaceuticals, Inc. expects that you will not disclose to it any proprietary information
or trade secrets of any former employer or bring onto its premises any unpublished documents or any
property belonging to any former employer. Since this would be improper, such conduct could be a
basis for discipline up to and including termination.

The above is subject to your signing a proprietary information and inventions agreement with the
Company, and the Company’s review of any agreement you may have with former employers to ensure
that they do not conflict with your employment with the Company. In addition, within three days
after your date of hire, you will be required to submit proof of identity and eligibility to work
in the United States, in compliance with federal immigration laws.

This offer has been extended to you on behalf of Anadys Pharmaceuticals, Inc. and is valid through
Monday, September 11th, 2006 by no later than 5:00 p.m. after which time it will expire.
This offer includes all the terms of your potential employment with the Company, and supersedes
all prior and contemporaneous negotiations, agreements and understandings between you and the
Company, oral or written.

Jim, we believe you will be able to make an immediate contribution to Anadys’ effort, and think you
will enjoy the rewards of working for an innovative, fast-paced, energetic company. One of the
keys to our accomplishments is our outstanding people. We hope you accept our offer to be one of
those people. Please acknowledge your agreement of these terms by signing this letter and
returning it to my attention in the enclosed envelope.

Sincerely yours,

ANADYS PHARMACEUTICALS, INC.

/s/ Kleanthis G. Xanthopoulos

Kleanthis G. Xanthopoulos, Ph.D.

President and Chief Executive Officer

I hereby accept this offer of employment and accept the terms as stated above. I understand that
as an employee of Anadys, I will be expected to comply with all Company policies:

	 	 	 
	/s/ James T. Glover

	 	9/11/2006
	 

	 	 
	James T. Glover, CPA

	 	Dateexv10w1

 

Exhibit 10.1

SEVENTH ADDENDUM

THIS SEVENTH ADDENDUM (“Seventh Addendum”), dated the 31st day of July, 2006, revises and
supplements the Transportation Agreement between the United States Postal Service (“USPS” or “the
Postal Service”) and Federal Express Corporation (“FedEx”).

BACKGROUND FACTS

On January 10, 2001, USPS and FedEx entered into the Transportation Agreement (“Agreement”)
which states that FedEx will provide for the transportation of certain USPS Products.

On December 13, 2001, USPS and FedEx entered into the Addendum to the Agreement (“Addendum”)
due to the USPS’ immediate need for the transportation of its Product over and above the Minimum
Guaranteed Volumes listed in the Agreement.

On April 3, 2002 and April 26, 2002, USPS and FedEx entered into the First Amendment to the
Addendum and the Second Amendment to the Addendum, respectively.

On August 29, 2002 and December 4, 2002, USPS and FedEx entered into the Second Addendum to
the Agreement (“Second Addendum”) and the First Amendment to the Second Addendum, respectively
which addressed the obligations of both parties through June 1, 2003.

On January 30, 2003, USPS and FedEx entered into the Third Addendum to the Agreement (“Third
Addendum”) which addressed the obligations of both parties through May 30, 2004.

On June 4, 2003, USPS and FedEx entered into the First Amendment to the Third Addendum.

On November 21, 2003 and December 8, 2003, USPS and FedEx entered into the Second Amendment to
the Third Addendum and the Third Amendment to the Third Addendum, respectively.

On March 16, 2004, USPS and FedEx entered into the Fourth Addendum.

On November 22, 2004, USPS and FedEx entered into the Fifth Addendum.

On June 9, 2006, USPS and FedEx entered into the Sixth Addendum.

The parties now desire to extend the Interim Period subject to the following terms:

 

 

 

AGREEMENT

	 	1.	 	Definitions

For the purposes of this Seventh Addendum, capitalized terms used as defined terms and not
otherwise defined in this Seventh Addendum shall have the meanings outlined in the Agreement. The
following additional terms shall have the following meaning:

“Billable Weekday Volume” means the greater of the actual Mid-week Volume tendered by USPS to
FedEx during the Schedule Period or [ * ] of the aggregate Daily Mid-Week Volume Commitment for
the Schedule Period.

“Billable Weekend Volume” means the greater of the actual Weekend Volume tendered by USPS to
FedEx during the Schedule Period or [ * ] of the aggregate Daily Weekend Volume Commitment for
the Schedule Period.

“Daily Mid-week Volume Commitment” means the daily volume committed for transport during the
Day Turn Operations on Tuesday through Friday of a week for a Schedule Period.

“Daily Weekend Volume Commitment” means the volume committed for transport during the Day Turn
Operations on Saturday and Sunday of a week for a Schedule Period.

“Interim Period” means the period of time commencing on August 1, 2006 and terminating
September 24, 2006.

“Night-Turn Mid-week Volume Commitment” means the daily volume committed for transport during
the Night-Turn Operations on Monday through Friday of a week for a Schedule Period.

“Non-Widely Observed Holiday” means Columbus Day, Veteran’s Day, President’s Day and Martin
Luther King Day.

“Offshore Locations” means [ * ].

“Operating Day” means any day other than a Monday or a FedEx Holiday for the Day-Turn
Operations.

“Revised Schedule Period Request Forecast” means the volume forecasting document which USPS
will provide to FedEx after the Schedule Period Request Forecast. USPS will provide the Revised
Schedule Period Request Forecast no later than [ * ] calendar days prior to each Schedule Block
Implementation Date.

	*	 	Blank spaces contained confidential information which has been filed separately with the
Securities and Exchange Commission pursuant to Rule 24b-2 under the Securities Exchange Act of
1934, as amended.

 

2

 

“Trucking Location” means a location specified on Exhibit A, attached.

“Weekend Volume” means volume transported during the Day Turn Operations on Saturday and
Sunday of a week.

	 	2.	 	Volume

(a) During the Interim Period, the Committed Volume and the Committed Volume Schedule will be
as set forth in the following table:

[ * ]

(b) During the Interim Period, USPS will tender and FedEx must transport between [ * ] and [
* ] of the Committed Volume for each applicable Schedule Block listed in the chart above.

	*	 	Blank spaces contained confidential information which has been filed separately with the
Securities and Exchange Commission pursuant to Rule 24b-2 under the Securities Exchange Act of
1934, as amended.

 

3

 

	 	3.	 	Schedule Period Request Forecast

Section 3.3.0 of Exhibit A of the Agreement is hereby modified for the Interim Period as
follows: For any Schedule Period in which the USPS Schedule Period Request Forecast is greater
than [ * ] the USPS shall deliver to FedEx a Revised Schedule Period Request Forecast no later
than [ * ] calendar days prior to each Schedule Block Implementation Date. [ * ] If USPS does
not make the Revised Schedule Period Request Forecast available by the required deadline, the
Schedule Period Request Forecast shall be used.

	 	4.	 	Non-Fuel Transport

During the Interim Period, FedEx will invoice USPS for the non-fuel transport portion of the
Day System pricing at the rates provided below:

[ * ]

	 	5.	 	No Non-Widely Observed Holiday

During the Interim Period, the parties agree that for those months in which there is no
Non-Widely Observed Holiday (i.e. June, 2006 and July, 2006), the monthly billed volume will be
computed on the following basis:

[ * ]

	*	 	Blank spaces contained confidential information which has been filed separately with the
Securities and Exchange Commission pursuant to Rule 24b-2 under the Securities Exchange Act of
1934, as amended.

 

4

 

	 	6.	 	Bypass Container Handling Charge 

During the Interim Period, FedEx and the USPS agree that notwithstanding the provisions of
Exhibit B, paragraph A(3) of the Agreement, USPS shall be invoiced a handling charge of [ * ] for
packages unloaded from By-pass ULDs which are destined to a Trucking Location. FedEx and USPS
agree to the following methodology to simplify invoicing:

FedEx will invoice USPS on the daily invoice at the contractual rate for all Handling Units,
including packages unloaded from a By-Pass ULD destined for a Trucking Location. FedEx will then
calculate a credit at the end of each Schedule Period. [ * ]

	 	7.	 	Density

The provisions of Exhibit B, paragraph A, subparagraphs 1 and 2 of the Agreement will be
revised for the Interim Period to eliminate the cubic footage conversion factor of [ * ]

	 	8.	 	7-day By-Pass Matrix Review

Section 3.6.0 of Exhibit A, Operating Specifications, is hereby modified for the Interim
Period as follows:

[ * ]

	*	 	Blank spaces contained confidential information which has been filed separately with the
Securities and Exchange Commission pursuant to Rule 24b-2 under the Securities Exchange Act of
1934, as amended.

 

5

 

	 	9.	 	Saturday Volume

Attachment 1 of the Agreement is hereby modified for the remaining Term of the Interim Period,
as follows:

USPS agrees that if the Daily Weekend Volume Commitment it tenders to
FedEx consists of equal amounts of volume for the Saturday and Sunday,
FedEx may tender not less than [ * ] of the Saturday volume on Saturday
and not less than [ * ] of the Saturday volume by noon Sunday (local
time at the destination market) to USPS with the remainder not later than
the Sunday tender times set forth in Attachment 1 to the Agreement.
However, the parties agree that if USPS desires a Daily Weekend Volume
Commitment which consists of a higher volume on Saturday than on Sunday,
USPS may do so by indicating its intent when it submits the Revised
Schedule Period Request Forecast which is required to be submitted no
later than [ * ] calendar days prior to each Schedule Block
Implementation Date. In such event, FedEx will only be required to tender
not less than [ * ] of the aggregate Weekend Volume Commitment on
Saturday and not less than [ * ] of the aggregate Weekend Volume
Commitment by noon Sunday. The parties shall cooperate in good faith to
identify those USPS locations where the distribution pattern described in
this paragraph will minimize inefficiencies in each organization.

	 	10.	 	Prior Agreements to be Extended

	 	(a)	 	Preliminary Network Flow

Notwithstanding the provisions of Section 3.6.0 of the Operating Specifications, during the
Interim Period, the parties agree that FedEx will not be required to furnish USPS with the
Preliminary Network Flow document.

	 	(b)	 	Service for Offshore Locations

During the Interim Period, the Market Service Commitment Time provided for in Attachments 1
and 2 to Exhibit A for volume to or from the Offshore Locations will be adjusted [ * ]. If USPS
requests FedEx to accept for transport an amount in excess of the maximum volumes for the Offshore
Locations but FedEx is unable to transport the excess volume to such destination by such adjusted
Market Service Commitment Time, FedEx shall tender such excess volume to the gateway for the
destination not later than the adjusted Market Service Commitment Time. The gateway locations for
the following destinations are: [ * ]

	*	 	Blank spaces contained confidential information which has been filed separately with the
Securities and Exchange Commission pursuant to Rule 24b-2 under the Securities Exchange Act of
1934, as amended.

 

6

 

	 	11.	 	Full Force and Effect

Except as amended by this Seventh Addendum, the terms and conditions of the Agreement shall
remain in full force and effect and are ratified and confirmed in all other respects.

	 	12.	 	Provision Conflict

If any provision of this Seventh Addendum conflicts with any provision of the Agreement, the
provision of the Agreement shall govern, unless otherwise provided for in the Addendum.

 

7

 

The parties have signed this Seventh Addendum in duplicate, one for each of the parties, as of
July 31, 2006.

	 	 	 	 	 
	 	 	THE UNITED STATES POSTAL SERVICE
	 
	 	 	 	 
	 

	 	By:
	 	/s/ LESLIE A. GRIFFITH
	 

	 	 	 	 
	 	 	Printed Name: Leslie A. Griffith
	 	 	Printed Title: Manager, Air Transportation
	 
	 	 	 	 
	 	 	FEDERAL EXPRESS CORPORATION
	 
	 	 	 	 
	 

	 	By:
	 	/s/ PAUL J. HERRON
	 

	 	 	 	 
	 	 	Printed Name: Paul J. Herron
	 	 	Printed Title: VP, Postal Transportation

 

8

 

Exhibit A

to the

Seventh Addendum

The Trucking Locations are as follows:

[ * ]

The list of Trucking Locations may be amended during the Interim Period by mutual agreement may be
amended during the Interim Period by mutual agreement of the parties.

	*	 	Blank spaces contained confidential information which has been filed separately with the
Securities and Exchange Commission pursuant to Rule 24b-2 under the Securities Exchange Act of
1934, as amended.

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