Document:

exh10_1.htm

    
      

    

    Summary
      Information

    Employee:  __________________

    Location:
      ___________________

    Date
      of
      Grant:  _______________

    Plan:  2007
      Equity Incentive Plan (formerly 1998 Plan)

    Total
      No.
      Shares subject to grant:  _____

    Vesting:
      _____ Shares vest on ______

    

    ICO,
      INC.

    2007
      EQUITY INCENTIVE PLAN

    

    RESTRICTED
      STOCK AGREEMENT

    (Time
      Vesting)

    

    THIS
      RESTRICTED STOCK AGREEMENT (“Agreement”) is made as of the __ day of
      ________, 20__ (“Date of Grant”), between ICO, Inc., a Texas corporation (the
“Company”), and __________________ (“Employee”).

    

    RECITALS:

    

    The
      Company has adopted the ICO Inc. 2007 Equity Incentive Plan (the “Plan”), a copy
      of which is attached hereto as Exhibit A, and all of the terms and provisions
      of
      which are incorporated herein by reference and made a part hereof. All
      capitalized terms used but not defined in this Agreement have the meanings
      set
      forth in the Plan.

    

    The
      Company has determined that it would be in the best interests of the Company
      and
      its shareholders to make the grant of stock provided for herein to the Employee
      to recognize the Employee’s value to the Company via the award of a proprietary
      interest in the future of the Company.

    

    NOW
      THEREFORE, in consideration of the mutual covenants hereinafter set
      forth, the parties hereto agree as follows:

    

    
      	
              1.

            	
              Grant
                of Restricted Stock. Subject to the terms of this Agreement, the
                Company hereby grants to the Employee, on the terms and conditions
                hereinafter set forth, an aggregate of _______________ shares of
                Common
                Stock, no par value per share, of the Company (the “Restricted
                Stock”).

            

    

    

    2.            
      Date of Grant and Vesting.

    

    
      	
               

            	
              A.

            	
              Date
                of Grant.  The effective date of the grant of Restricted
                Stock shall be the Date of Grant.

            

    

    

    
      	
               

            	
              B.

            	
              Vesting
                Date. ___________ (__%) of the shares of Restricted Stock granted
                to
                the Employee hereunder, subject to the other terms and conditions
                set
                forth herein, shall be vested on the Date of Grant.  An
                additional __________ (__%) of  the shares of Restricted Stock
                will be vested on [each subsequent anniversary of the Date of
                Grant].

            

    

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    

    
      	
               

            	
              C.

            	
              Termination
                of Employment. Except as provided in Section 2.D. below, upon any
                termination of employment of the Employee, any shares of Restricted
                Stock
                that have not vested shall be forfeited to the Company without
                consideration.

            

    

    

    
      	
               

            	
              D.

            	
              Termination
                of Employment Due to Death.  In the event that the
                employment of the Employee terminates because of the death of the
                Employee, all shares of Restricted Stock granted to the Employee
                hereunder
                shall vest immediately upon the date of termination of
                employment.

            

    

    

    
      	
              3.

            	
              Retention
                of Certificates. All original certificates evidencing shares of
                Restricted Stock shall be held by the Company for the benefit of
                the
                Employee until the transfer of such shares are no longer subject
                to the
                restrictions set out in the Plan and this
                Agreement.

            

    

    

    
      	
              4.

            	
              Employment
                of the Employee. The Employee acknowledges and agrees that
                neither the issuance of the Restricted Stock to the Employee nor
                any
                provision contained herein shall entitle the Employee to remain in
                the
                employment of the Company or its affiliates or affect the right of
                the
                Company to terminate the Employee’s employment at any
                time.

            

    

    

    
      	
              5.

            	
              Restrictions
                on Transfer.  The Employee shall not sell, transfer,
                assign, pledge or otherwise dispose of any interest in any shares
                of
                Restricted Stock or his rights under this Agreement before the Vesting
                Date.  Under no circumstances shall any sale or other transfer
                of any shares of Restricted Stock be valid unless and until the shares
                proposed to be sold or transferred are fully
                vested.

            

    

    

    
      	
               

            	
              A.

            	
              Stop-Transfer
                Notices. The Employee agrees that to ensure compliance with the
                restrictions referred to herein, the Company may issue appropriate
“stop
                transfer” instructions to its transfer agent, if any, and that, if the
                Company transfers its own securities, it may make appropriate notations
                to
                the same effect in its own records.

            

    

    

    
      	
               

            	
              B.

            	
              Refusal
                to Transfer. The Company shall not be required (i) to transfer on its
                books any shares of Restricted Stock that have been sold or otherwise
                transferred in violation of any of the provisions of this Agreement
                or
                (ii) to treat as owner of such shares or to accord the right to vote
                or
                pay dividends to any purchaser or other transferee to whom such shares
                shall have been so transferred.

            

    

    

    
      	
              6.

            	
              Distributions.
                The Employee shall receive distributions on the Employee’s shares of
                Restricted Stock prior to the date such shares have become vested
                under
                Section 2 above.

            

    

    

    
      	
              7.

            	
              Notices;
                Deliveries. Any notice or delivery required to be given under the
                terms of this Agreement shall be addressed to the Company at its
                principal
                office, and any notice or delivery to be given to the Employee shall
                be
                addressed to him or her at the address given by him or her beneath
                his or
                her signature hereto or such other address as either party hereto
                may
                hereafter designate in writing to the other. Any such notice or delivery
                shall be deemed to have been duly given when addressed as aforesaid,
                registered or certified mail, and deposited (postage or registration
                or
                certification fee prepaid) in a post office or branch post office
                regularly maintained by the United
                States.

            

    

    
      
         

      

      
        Page
          2 of 7

        
          

        

      

      
         

      

    

    
      	
              8.

            	
              Disputes.
                As a condition of the granting of the Restricted Stock hereby, the
                Employee and his or her heirs and successors agree that any dispute
                or
                disagreement that may arise hereunder shall be determined by the
                Company’s
                Board of Directors (or, at the Board of Directors’ election, the Committee
                that administers the Plan, if any), in its sole discretion and
                judgment.

            

    

    

    9.            
      Certificates.

    

    
      	
               

            	
              A.

            	
              The
                certificate(s) representing the shares of Restricted Stock granted
                hereby
                will be stamped or otherwise imprinted with the legend required by
                the
                Plan with respect to any applicable restrictions on the sale or transfer
                of such shares, and the stock transfer records of the Company will
                reflect
                stop transfer instructions with respect to such shares. This legend
                shall
                be as follows:

            

    

    

    THE
      TRANSFER OF THIS CERTIFICATE AND THE SHARES OF STOCK REPRESENTED HEREBY ARE
      SUBJECT TO THE RESTRICTIONS, TERMS AND CONDITIONS (INCLUDING FORFEITURE,
      RESTRICTIONS AGAINST TRANSFER, SALE, PLEDGE, OR OTHER DISPOSITION), CONTAINED
      IN
      THE 2007 EQUITY INCENTIVE PLAN OF THE CORPORATION AND AN AGREEMENT ENTERED
      INTO
      BETWEEN THE REGISTERED OWNER OF SUCH SHARES AND THE CORPORATION. THIS
      CERTIFICATE IS TRANSFERABLE ONLY IN COMPLIANCE WITH AND SUBJECT TO THE
      PROVISIONS OF SUCH PLAN AND AGREEMENT. UPON THE OCCURRENCE OF CERTAIN EVENTS,
      THIS CERTIFICATE MAY BE CANCELED WITHOUT NOTICE TO THE HOLDER HEREOF IF SUCH
      HOLDER IS NOT LISTED AS THE REGISTERED HOLDER ON THE BOOKS OF THE CORPORATION.
      A
      COPY OF THE PLAN AND AGREEMENT IS ON FILE IN THE OFFICE OF THE SECRETARY OF
      THE
      CORPORATION, 1811 BERING DRIVE, SUITE 200, HOUSTON, TEXAS 77057.

    

    
      	
               

            	
              B.

            	
              The
                Company shall retain the certificate(s) representing the shares of
                Restricted Stock granted to the Employee pursuant to this Agreement
                until
                such time as the vesting restrictions set forth in Section 2 have
                lapsed
                or are removed by the Committee. Within a reasonable time thereafter,
                the
                Company will deliver to the Employee a new certificate representing
                such
                shares, free of the legend referred to in paragraph (A) above. The
                issuance of such certificate shall not affect any restrictions upon
                the
                transferability of such shares pursuant to applicable law or
                otherwise.

            

    

    

    
      	
               

            	
              C.

            	
              Any
                stock certificate(s) representing the shares of Restricted Stock
                granted
                hereunder prior to the termination or lapse of the restrictions on
                vesting
                and transfer shall reflect the legend referred to in paragraph (A)
                above
                which shall remain on such certificate(s) until such time as the
                vesting
                and transfer restrictions have terminated or lapsed or are removed
                by the
                Committee.

            

    

    

    
      	
              10.

            	
              Restricted
                Stock Subject to Plan. The Restricted Stock granted hereby is
                subject to the Plan. If a conflict exists between any term or provision
                contained herein and a term or

            

    

    
      
         

      

      
        Page
          3 of 7

        
          

        

      

      
         

      

    

          
      provision of the Plan, the applicable terms and provisions of the Plan will
      govern and prevail.

    

    
      	
              11.

            	
              Miscellaneous.

            

    

    

    
      	
               

            	
              A.

            	
              The
                Employee acknowledges that each date on which a portion of the shares
                of
                Restricted Stock becomes vested will result in the imposition of
                income
                and employment taxes on the
                Employee.

            

    

    

    
      	
               

            	
              B.

            	
              The
                Employee hereby agrees that (i) the Company may withhold from the
                Employee
                any payment or consideration to be paid to the Employee by the Company,
                any tax which the Company believes is required to be withheld with
                respect
                to any benefit under the Plan or this Restricted Stock Agreement,
                or, in
                lieu thereof, to retain, or sell without notice, a sufficient number
                of
                shares of stock to cover the amount required to be withheld, and
                to hold
                as security for the amount to be withheld any property otherwise
                distributable to the Employee under the Plan until the amounts required
                to
                be withheld have been so withheld; and (ii) the Employee will make
                appropriate arrangements with the Company for satisfaction of any
                applicable federal, state or local income tax, withholding requirements
                or
                like requirements.  For the purpose of this paragraph, the
                “Company” refers to Employee’s employer within the ICO, Inc. family of
                Companies.

            

    

    

    
      	
               

            	
              C.

            	
              If
                any party to this Agreement so required under this Agreement falls
                or
                refuses to comply with the provisions of this Agreement, then in
                addition
                to any other remedies provided by law or this Agreement, the party
                affected thereby may institute and maintain a proceeding to compel
                the
                specific performance of this Agreement by the party so
                defaulting.

            

    

    

    
      	
               

            	
              D.

            	
              This
                Agreement shall be binding upon and inure to the benefit of any successor
                or successors of the Company.

            

    

    

    
      	
               

            	
              E.

            	
              The
                interpretation, performance and enforcement of this Agreement shall
                be
                governed by the laws of the State of
                Texas.

            

    

    

    
      	
               

            	
              F.

            	
              This
                Agreement may be executed in multiple counterparts, each of which
                shall be
                deemed an original, but all of which collectively shall constitute
                a
                single instrument.

            

    

    

    
      	
               

            	
              G.

            	
              If
                any one or more of the provisions or parts of a provision contained
                in
                this Agreement shall for any reason be held to be invalid, illegal
                or
                unenforceable in any respect in any jurisdiction, such invalidity,
                illegality or unenforceability shall not affect any other provision
                or
                part of a provision of this Agreement or any other jurisdiction,
                but this
                Agreement shall be reformed and construed in any such jurisdiction
                as if
                such invalid or illegal or unenforceable provision or part of a provision
                had never been contained herein and such provision or part shall
                be
                reformed so that it would be valid, legal and enforceable to the
                maximum
                extent permitted in such
                jurisdiction.

            

    

    
      
         

      

      
        Page
          4 of 7

        
          

        

      

      
         

      

    

    

    
      	
               

            	
              H.

            	
              Within
                30 days after the date of this Agreement, the Employee may make an
                election with the Internal Revenue Service under Section 83(b) of
                the
                Internal Revenue Code and the regulations promulgated
                thereunder.

            

    

    

    IN
      WITNESS WHEREOF, the Company has, as of the date first above written,
      caused this Agreement to be executed on its behalf by its authorized officer
      and
      the Employee has hereunto set his or her hand as of the date first above
      written.

    

    

    
      	 	
              ICO,
                INC.

            
	 	 
	 	
              By:

            	 
	 	 	 
	 	
              Its:

            	 

    

    

    
      
         

      

      
        Page
          5 of 7

        
          

        

      

      
         

      

    

    EMPLOYEE
      SIGNATURE PAGE

    TO
      RESTRICTED STOCK AGREEMENT

    

    

    
      	
              Employee
                Name:

            	 
	 	 
	 	 
	
              Signature:

            	 
	 	 
	
              Address:

            	 
	 	 
	 	 

    

    

    

    
      
         

      

      
        Page
          6 of 7

        
          

        

      

      
         

      

    

    EXHIBIT
      A

    

    [Attach
      2007 Equity Incentive Plan Document]

    

     

     

     

    Page
      7 of
      7exv4w2

 

Exhibit 4.2

CONCENTRIC MEDICAL, INC.

THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

     This Third Amended and Restated Investors’ Rights Agreement (the “Agreement”) is made
as of the 30th day of September, 2005, by and among Concentric Medical, Inc., a Delaware
corporation (the “Company”), and the investors listed on Exhibit A hereto, each of
which is herein referred to as an “Investor” and collectively as the “Investors.”

RECITALS

     WHEREAS, the Company and certain of the Investors (the “Existing Investors”) entered
into the Second Amended and Restated Investors’ Rights Agreement dated December 19, 2003 (the
“Second Amended Agreement”), pursuant to which the Company granted (i) certain rights to
register shares of the Company’s Common Stock issuable upon conversion of the Series A Preferred
Stock, Series B Preferred Stock and Series C Preferred Stock, (ii) certain rights to receive or
inspect information pertaining to the Company, and (iii) a right of first offer with respect to
certain issuances by the Company of its securities.

     WHEREAS, the Company and certain of the Investors are entering into a Series D Preferred Stock
Purchase Agreement (the “Series D Purchase Agreement”) of even date herewith pursuant to
which the Company shall sell to such Investors and such Investors shall purchase from the Company
shares of the Company’s Series D Preferred Stock. A condition to the Investors’ obligations under
the Series D Purchase Agreement is that the Company and the Investors enter into this Agreement in
order to provide the Investors (i) certain rights to register shares of the Company’s Common Stock
issuable upon conversion of the Series D Preferred Stock held by the Investors, (ii) certain rights
to receive or inspect information pertaining to the Company, and (iii) a right of first offer with
respect to certain issuances by the Company of its securities.

     WHEREAS, the Second Amended Agreement may be amended with the consent of the Company and the
holders of a majority of the Registrable Securities (as defined in the Second Amended Agreement)
then outstanding.

     WHEREAS, the Company and the Existing Investors (who are holders of a majority of the
outstanding Registrable Securities (as defined in the Second Amended Agreement)) now wish to amend
and restate the Second Amended Agreement in order to grant all of the Investors certain
registration rights, information rights and a right of first offer with respect to certain
issuances by the Company of its securities.

     NOW, THEREFORE, in consideration of the mutual promises and covenants set forth herein, the
Company and the Investors hereby agree, intending to be legally bound hereby, that the Second
Amended Agreement shall be superseded and replaced in its entirety by this Agreement, and the
parties hereto further agree as follows:

 

 

AGREEMENT

     1. Registration Rights. The Company and the Investors covenant and agree as follows:

          1.1 Definitions. For purposes of this Section 1:

               (a) The term “Common Stock” means (i) the common stock, par value $0.001
per share, of
the Company, (ii) any other capital stock of any class or classes (however designated) of the
Company, authorized on or after the date hereof, the holders of which shall have the right, without
limitation as to amount, either to all or to a share of the balance of current dividends and
liquidating distributions after the payment of dividends and distributions on any shares entitled
to preference in the distribution of assets upon the voluntary or involuntary dissolution of the
Company, and the holders of which shall ordinarily, in the absence of contingencies or in the
absence of any provision to the contrary in the Certificate of Incorporation, be entitled to vote
for the election of a majority of directors of the Company (even though the right so to vote has
been suspended by the happening of such a contingency or provision), and (iii) any other securities
into which or for which any of the securities described in (i) or (ii) may be converted or
exchanged pursuant to a plan of recapitalization, reorganization, merger, sale of assets or other
similar transaction.

               (b) The term “Form S-3” means such form promulgated under the Securities
Act as in
effect on the date hereof or any similar or successor form promulgated under the Securities Act
that permits significant incorporation by reference of the Company’s subsequent public filings
under the Securities Exchange Act of 1934, as amended, or any similar or successor federal statute
(the “Exchange Act”);

               (c) The term “Holder” means any person owning or having the right to acquire
Registrable Securities (including Senior Registrable Securities) or any assignee thereof in
accordance with Section 1.12 of this Agreement and shall include, without limitation, Lighthouse
Capital Partners V, L.P. and Lighthouse Capital Partners IV, L.P. (collectively,
“Lighthouse”);

               (d) The term “Qualified IPO” means a firm commitment underwritten public
offering by
the Company of shares of its Common Stock pursuant to a registration statement under the Securities
Act, the public offering price of which is not less than $2.58 per share (as appropriately adjusted
for any stock split, dividend, combination or other recapitalization) and which results in
aggregate gross proceeds to the Company of at least $30,000,000 or pursuant to which all
outstanding shares of Preferred Stock are converted into Common Stock;

               (e) The terms “register,” “registered,” and
“registration” refer to a
registration effected by preparing and filing a registration statement or similar document in
compliance with the Securities Act of 1933, as amended, or any similar or successor federal statute
(the “Securities Act”), and the declaration or ordering of effectiveness of such
registration statement or document;

-2-

 

               (f) The term “Registrable Securities” means (i) the shares of Common
Stock issuable or
issued upon conversion of the Series A Preferred Stock, Series B Preferred Stock (including shares
of Series B Preferred Stock issuable upon the exercise of warrants held by Comerica Incorporated
pursuant to that certain Loan and Security Agreement, dated February 20, 2003, between the Company
and Comerica Bank – California), Series C Preferred Stock or Series D Preferred Stock (the
“Preferred Stock”) other than shares for which registration rights have terminated pursuant
to Section 1.15 hereof, (ii) all shares of Common Stock of the Company now or hereafter held by
Lighthouse, issued or issuable upon conversion of the shares of Series C Preferred Stock issued or
issuable upon exercise of that certain Warrant to purchase Series C Preferred Stock held by
Lighthouse; and (iii) any other shares of Common Stock of the Company issued as (or issuable upon
the conversion or exercise of any warrant, right or other security which is issued as) a dividend
or other distribution with respect to, or in exchange for or in replacement of, the shares listed
in (i) or in this section (ii); provided, however, that the foregoing definition
shall exclude in all cases any Registrable Securities (A) sold by a person in a transaction in
which his or her rights under this Agreement are not assigned, (B) sold to or through a broker or
dealer or underwriter in a public distribution or a public securities transaction, or (C) sold in a
transaction exempt from the registration and prospectus delivery requirements of the Securities Act
under Section 4(1) thereof so that all transfer restrictions, and restrictive legends with respect
thereto, if any, are removed upon the consummation of such sale;

               (g) The number of shares of “Registrable Securities then outstanding” shall be
equal
to the number of shares of Common Stock outstanding which are, and the number of shares of Common
Stock issuable pursuant to then exercisable or convertible securities which are, Registrable
Securities;

               (h) The term “SEC” means the Securities and Exchange Commission; and

               (i) The term “Senior Registrable Securities” means Registrable Securities
issuable or
issued upon conversion of the Series B Preferred Stock, Series C Preferred Stock and Series D
Preferred Stock.

          1.2 Request for Registration.

               (a) If the Company shall receive at any time after the earlier of (i) the third
anniversary of
this agreement or (ii) six (6) months after the effective date of the first registration statement
for a public offering of securities of the Company (other than a registration statement relating
either to the sale of securities to employees of the Company pursuant to a stock option, stock
purchaser or similar plan or a transaction pursuant to Rule 145 promulgated under the Securities
Act) a written request from the Holders of at least a majority of the Registrable Securities then
outstanding that the Company file a registration statement under the Securities Act covering the
registration of Registrable Securities, the aggregate offering price of which is at least
$3,000,000, then the Company shall, within ten days of the receipt thereof, give written notice of
such request to all Holders and shall, subject to the limitations of subsection 1.2(b), use its
best efforts to effect as soon as practicable, and in any event within 60 days of the receipt of
such request, the registration under the Securities Act of all Registrable Securities which the
Holders request to be registered within 20 days of the mailing of such notice

-3-

 

by the Company
in accordance with Section 3.4. No securities other than Registrable Securities shall be included
in the registration unless consented to, in writing, by the Holders of at least a majority of the
Senior Registrable Securities.

               (b) If the Holders initiating the registration request hereunder (“Initiating
Holders”) intend to distribute the Registrable Securities covered by their request by means of
an underwriting, they shall so advise the Company as a part of their request made pursuant to this
Section 1.2 and the Company shall include such information in the written notice referred to in
subsection 1.2(a). The underwriter will be selected by a majority in interest of the Initiating
Holders and shall be reasonably acceptable to the Company. In such event, the right of any Holder
to include its Registrable Securities in such registration shall be conditioned upon such Holder’s
participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the
underwriting (unless otherwise mutually agreed by a majority in interest of the Initiating Holders
and such Holder) to the extent provided herein. All Holders proposing to distribute their
securities through such underwriting shall (together with the Company as provided in subsection
1.5(e)) enter into an underwriting agreement in customary form with the underwriter or underwriters
selected for such underwriting. Notwithstanding any other provision of this Section 1.2, if the
underwriter advises the Initiating Holders in writing that marketing factors require a limitation
of the number of shares to be underwritten, then the Initiating Holders shall so advise all Holders
of Registrable Securities which would otherwise be underwritten pursuant hereto, and the number of
shares of Registrable Securities that may be included in the underwriting shall be allocated among
all Holders thereof, including the Initiating Holders, in proportion (as nearly as practicable) to
the amount of Registrable Securities of the Company owned by each Holder; provided,
however, that the number of shares of Registrable Securities to be included in such
underwriting shall not be reduced unless all other securities are first entirely excluded from the
underwriting.

               (c) Notwithstanding the foregoing, if the Company shall furnish to Holders requesting a
registration statement pursuant to this Section 1.2, a certificate signed by the President of the
Company stating that in the good faith judgment of the Board of Directors of the Company (the
“Board”), it would be seriously detrimental to the Company and its stockholders for such
registration statement to be filed and it is therefore essential to defer the filing of such
registration statement, the Company shall have the right to defer such filing for a period of not
more than 90 days after receipt of the request of the Initiating Holders; provided,
however, that the Company may not utilize this right more than once in any twelve-month
period.

               (d) In addition, the Company shall not be obligated to effect, or to take any action to
effect, any registration pursuant to this Section 1.2:

                    (i) After the Company has effected two registrations pursuant to
this Section 1.2 that (x)
have been declared or ordered effective and remained effective until at least 80% of the
Registrable Securities registered thereunder were sold or the period set forth in Section 1.5(a)
expired, and (y) the Company has not included any securities for its own account in such
registration statement;

-4-

 

                    (ii) If the Company delivers written notice to the requesting
Holders within 30 days following
such Holders’ request for registration that it in good faith intends to file a registration
statement for the initial public offering of securities of the Company (other than a registration
statement relating either to the sale of securities to employees of the Company pursuant to a stock
option, stock purchase or similar plan or an SEC Rule 145 transaction) within 90 days following the
Company’s notice;

                    (iii) During the period starting with the date 30 days prior
to the Company’s good faith
estimate of the date of filing of, and ending on a date 120 days after the effective date of, a
registration subject to Section 1.3 hereof covering an underwritten public offering in which the
Holders of Registrable Securities are permitted to participate; provided that the Company
is actively employing in good faith all reasonable efforts to cause such registration statement to
become effective; or

                    (iv) If the Initiating Holders propose to dispose of shares of
Registrable Securities that may
be immediately registered on Form S-3 pursuant to a request made pursuant to Section 1.4 below;
provided that such registration shall not be counted as one of the requested registrations
under Section 1.2.

          1.3 Company Registration. If (but without any obligation to do so) the Company
proposes to register (including without limitation for this purpose a registration effected by the
Company for stockholders other than the Holders) any of its stock under the Securities Act in
connection with the public offering of such securities solely for cash (other than a registration
relating solely to the sale of securities to participants in a Company stock plan or a transaction
covered by Rule 145 under the Securities Act, a registration in which the only stock being
registered is Common Stock issuable upon conversion of debt securities which are also being
registered, or any registration on any form which does not include substantially the same
information as would be required to be included in a registration statement covering the sale of
the Registrable Securities), the Company shall, at such time, promptly give each Holder written
notice of such registration. Upon the written request of each Holder given within 20 days after
mailing of such notice by the Company in accordance with Section 3.4, the Company shall, subject to
the provisions of Section 1.8, cause to be registered under the Securities Act all of the
Registrable Securities that each such Holder has requested to be registered. The number of times a
Holder may register Registrable Securities under this Section 1.3 shall be unlimited.

          1.4 Form S-3 Registration. After consummation of its initial public offering of its
Common Stock, the Company shall use its best efforts to qualify for registration on Form S-3. In
case the Company shall receive from any Holder or Holders of Registrable Securities then
outstanding a written request or requests that the Company effect a registration on Form S-3 and
any related qualification or compliance with respect to all or a part of the Registrable Securities
owned by such Holder or Holders, the Company will:

               (a) promptly give written notice of the proposed registration, and any related qualification
or compliance, to all other Holders; and

               (b) as soon as practicable, effect such registration and all such qualifications and
compliances as may be so requested and as would permit or facilitate the sale

-5-

 

and distribution of
all or such portion of such Holder’s or Holders’ Registrable Securities as are specified in such
request, together with all or such portion of the Registrable Securities of any other Holder or
Holders joining in such request as are specified in a written request given within 20 days after
receipt of such written notice from the Company; provided, however, that the
Company shall not be obligated to effect any such registration, qualification or compliance,
pursuant to this Section 1.4: (i) if Form S-3 is not available for such offering by the Holders;
(ii) if the Holders, together with the holders of any other securities of the Company entitled to
inclusion in such registration, propose to sell Registrable Securities and such other securities
(if any) at an aggregate offering price to the public of less than $1,500,000; (iii) if the Company
shall furnish to the Holders a certificate signed by the President of the Company stating that in
the good faith judgment of the Board of Directors of the Company, it would be seriously detrimental
to the Company and its stockholders for such Form S-3 Registration to be effected at such time, in
which event the Company shall have the right to defer the filing of the Form S-3 registration
statement for a period of not more than 45 days after receipt of the request of the Holder or
Holders under this Section 1.4; provided, however, that the Company shall not
utilize this right more than once in any twelve-month period; (iv) if the Company has, within the
twelve-month period preceding the date of such request, already effected two registrations on Form
S-3 for the Holders pursuant to this Section 1.4; (v) in any particular jurisdiction in which the
Company would be required to qualify to do business or to execute a general consent to service of
process in effecting such registration, qualification or compliance; or (vi) during the period
ending 90 days after the effective date of a registration statement subject to Section 1.3.

               (c) Subject to the foregoing, the Company shall file a registration statement covering the
Registrable Securities and other securities so requested to be registered as soon as practicable,
and in any event within 20 days, after receipt of the request or requests of the Holders.
Registrations effected pursuant to this Section 1.4 shall not be counted as demands for
registration or registrations effected pursuant to Sections 1.2 or 1.3, respectively.

          1.5 Obligations of the Company. Whenever required under this Section 1 to effect the
registration of any Registrable Securities, the Company shall, as expeditiously as reasonably
possible:

               (a) Prepare and file with the SEC a registration statement with respect to such Registrable
Securities (which, in the case of an underwritten public offering pursuant to Section 3, shall be
on Form S-1 or other form of general applicability satisfactory to the managing underwriter
selected as therein provided) including executing an undertaking to file post-effective amendments
and use its best efforts to cause such registration statement to become and remain effective for
the period of the distribution contemplated thereby.

               (b) Prepare and file with the SEC such amendments and supplements to such registration
statement and the prospectus used in connection with such registration statement as may be
necessary to keep such registration statement effective for the period specified herein and comply
with the provisions of the Securities Act with respect to the disposition of all
Registrable Securities covered by such registration statement in accordance with the sellers’
intended method of disposition set forth in such registration statement for such period.

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               (c) Furnish to the Holders and to each underwriter such number of copies of the registration
statement and each such amendment and supplement thereto (in each case including all exhibits) and
the prospectus included therein (including each preliminary prospectus) as such persons reasonably
may request in order to facilitate the public sale or other disposition of the Registrable
Securities covered by such registration statement.

               (d) Use its best efforts to register and qualify the securities covered by such registration
statement under such other securities or Blue Sky laws of such jurisdictions as shall be reasonably
requested by the Holders, provided that the Company shall not be required in connection
therewith or as a condition thereto to qualify to do business or to file a general consent to
service of process in any such states or jurisdictions unless the Company is required to do so
under the Securities Act.

               (e) In the event of any underwritten public offering, enter into and perform its obligations
under an underwriting agreement, in usual and customary form, with the managing underwriter of such
offering. Each Holder participating in such underwriting shall also enter into and perform its
obligations under such an agreement.

               (f) Comply with all applicable rules and regulations under the Securities Act and Exchange
Act.

               (g) Immediately notify each seller of Registrable Securities and each underwriter under such
registration statement, at any time when a prospectus relating thereto is required to be delivered
under the Securities Act, of the happening of any event of which the Company has knowledge as a
result of which the prospectus contained in such registration statement, as then in effect,
includes an untrue statement of a material fact or omits to state a material fact required to be
stated therein or necessary to make the statements therein not misleading in light of the
circumstances then existing, and promptly prepare and furnish to such seller a reasonable number of
copies of a prospectus supplemented or amended so that, as thereafter delivered to the purchasers
of such Registrable Securities, such prospectus shall not include an untrue statement of a material
fact or omit to state a material fact required to be stated therein or necessary to make the
statements therein not misleading in light of the circumstances then existing.

               (h) Make available for inspection by each seller of Registrable Securities, any underwriter
participating in any distribution pursuant to such registration statement, and any attorney,
accountant or other agent retained by such seller or underwriter, reasonable access to all
financial and other records, pertinent corporate documents and properties of the Company, as such
parties may reasonably request, and cause the Company’s officers, directors and employees to supply
all information reasonably requested by any such seller, underwriter, attorney, accountant or agent
in connection with such registration statement.

               (i) Cooperate with the selling holders of Registrable Securities and the managing underwriter,
if any, to facilitate the timely preparation and delivery of certificates
representing Registrable Securities to be sold, such certificates to be in such denominations
and registered in such names as such holders or the managing underwriter may request at least two
business days prior to any sale of Registrable Securities.

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               (j) Cause all such Registrable Securities registered hereunder to be listed on each securities
exchange (including the Nasdaq Stock Market) on which similar securities issued by the Company are
then listed.

               (k) Provide a transfer agent and registrar for all Registrable Securities registered hereunder
and a CUSIP number for all such Registrable Securities, in each case not later than the effective
date of such registration.

               (l) If the offering is underwritten and at the request of any seller of Registrable
Securities, furnish on the date that Registrable Securities are delivered to the underwriters for
sale pursuant to such registration (i) an opinion dated such date of counsel representing the
Company for the purposes of such registration, addressed to the underwriters to such effects as
reasonably may be requested by counsel for the underwriters and executed counterparts of such
opinion addressed to the sellers of Registrable Securities to the same effect as requested by
counsel for the underwriters and (ii) a letter dated such date from the independent public
accountants retained by the Company, addressed to the underwriters and executed counterparts of
such letter addressed to the Sellers of Registrable Securities stating that they are independent
public accountants within the meaning of the Securities Act and that, in the opinion of such
accountants, the financial statements of the Company included in the registration statement or the
prospectus, or any amendment or supplement thereof, comply as to form in all material respects with
the applicable accounting requirements of the Securities Act and such letter shall additionally
cover such other financial matters (including information as to the period ending no more than five
(5) business days prior to the date of such letter) with respect to such registration as such
underwriters reasonably may request.

     For purposes of this Agreement, the period of distribution of Registrable Securities in a firm
commitment underwritten public offering shall be deemed to extend until each underwriter has
completed the distribution of all securities purchased by it, and the period of distribution of
Registrable Securities in any other registration shall be deemed to extend until the earlier of the
sale of all Registrable Securities covered thereby or 180 days after the effective date thereof,
provided, however, in the case of any registration of Registrable Securities on
Form S-3 or a comparable or successor form which are intended to be offered on a continuous or
delayed basis, such 180 day-period shall be extended, if necessary, to keep the registration
statement effective until all such Registrable Securities are sold, provided that Rule 415,
or any successor or similar rule promulgated under the Securities Act, permits an offering on a
continuous or delayed basis, and provided further that applicable rules under the
Securities Act governing the obligation to file a post-effective amendment, permit, in lieu of
filing a post-effective amendment which (y) includes any prospectus required by Section 10(a)(3) of
the Securities Act or (z) reflects facts or events representing a material or fundamental change in
the information set forth in the registration statement, the incorporation by reference of
information required to be included in (y) and (z) above contained in periodic reports filed
pursuant to Section 13 or 15(d) of the Exchange Act in the registration statement.

          1.6 Furnish Information. It shall be a condition precedent to the obligations of the
Company to file a registration statement pursuant to this Section 1 with respect to the Registrable
Securities of any selling Holder that such Holder shall furnish to the Company such

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information
regarding itself, the Registrable Securities held by it, and the intended method of disposition of
such securities as shall be reasonably requested by the Company in writing to effect the
registration of such Holder’s Registrable Securities.

          1.7 Expenses of Registration.

               (a) Demand Registration. All expenses (other than underwriting discounts
and
commissions) incurred in connection with registrations, filings or qualifications pursuant to
Section 1.2, including (without limitation) all registration, filing and qualification fees,
printers’ and accounting fees, fees and disbursements of counsel for the Company, and the
reasonable fees and disbursements of one counsel for the selling Holders selected by a majority in
interest of the selling Holders, shall be borne by the Company; provided, however,
that the Company shall not be required to pay for any expenses of any registration proceeding begun
pursuant to Section 1.2 if the registration request is subsequently withdrawn at the request of the
Holders of a majority of the Registrable Securities to be registered (in which case all
participating Holders shall bear such expenses), unless the Holders of a majority of the
Registrable Securities agree to forfeit their right to one demand registration pursuant to Section
1.2; provided, further, however, that if at the time of such withdrawal,
the Holders have learned of a material adverse change in the condition, business or prospects of
the Company from that known to the Holders at the time of their request and have withdrawn the
request with reasonable promptness following disclosure by the Company of such material adverse
change, then the Holders shall not be required to pay any of such expenses and shall retain their
rights pursuant to Section 1.2.

               (b) Company Registration. All expenses (other than underwriting discounts
and
commissions) incurred in connection with registrations, filings or qualifications of Registrable
Securities pursuant to Section 1.3 for each Holder (which right may be assigned as provided in
Section 1.12), including (without limitation) all registration, filing, and qualification fees,
printers’ and accounting fees, fees and disbursements of counsel for the Company and the reasonable
fees and disbursements of one counsel for the selling Holder or Holders selected by a majority in
interest of the selling Holders, shall be borne by the Company.

               (c) Registration on Form S-3. All expenses (excluding any
underwriters’ discounts or
commissions associated with Registrable Securities) incurred in connection with a registration
requested pursuant to Section 1.4, including (without limitation) all registration, filing,
qualification, printers’ and accounting fees and the reasonable fees and disbursements of one
counsel for the selling Holder or Holders selected by a majority in interest of the selling
Holders, shall be borne by the Company, and counsel for the Company, shall be borne by the Company.

          1.8 Underwriting Requirements. In connection with any offering involving an
underwriting of shares of the Company’s capital stock, the Company shall not be required under
Section 1.3 to include any of the Holders’ securities in such underwriting unless they
accept the terms of the underwriting as agreed upon between the Company and the underwriters
selected by it (or by other persons entitled to select the underwriters), and then only in such
quantity as the underwriters determine in their sole discretion will not jeopardize the success of

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the offering by the Company. If the total amount of securities, including Registrable Securities,
requested by stockholders to be included in such offering exceeds the amount of securities to be
sold other than by the Company that the underwriters determine in their sole discretion is
compatible with the success of the offering, then the Company shall be required to include in the
offering only that number of such securities, including Registrable Securities, which the
underwriters determine in their sole discretion will not jeopardize the success of the offering;
provided, that no securities shall be included in the registration other than by the
Company for its own account unless all Registrable Securities requested to be included in the
registration are so included; provided, further, that in no event shall the amount
of Senior Registrable Securities requested to be included in the offering be reduced unless all
other Registrable Securities shall have first been excluded from the offering; provided,
further, that in no event shall the amount of Registrable Securities included in the
offering be reduced below 30% of the total amount of securities included in such offering.

          1.9 Delay of Registration. No Holder shall have any right to obtain or seek an
injunction restraining or otherwise delaying any such registration as the result of any controversy
that might arise with respect to the interpretation or implementation of this Section 1.

          1.10 Indemnification. In the event any Registrable Securities are included in a
registration statement under this Section 1:

               (a) To the extent permitted by law, the Company will indemnify and hold harmless each Holder,
each of its officers, directors, partners, members, any underwriter (as defined in the Securities
Act) for such Holder, each of its officers, directors, partners, members, and each person, if any,
who controls such Holder or underwriter within the meaning of the Securities Act or the Exchange
Act against any losses, claims, damages, expenses or liabilities (or actions, proceedings or
settlements in respect thereof), whether joint or several to which they may become subject under
the Securities Act, the Exchange Act or other federal or state law, or at common law, and, except
as hereinafter provided, will reimburse each such Holder, each such underwriter and each such
controlling person, if any, for any legal or other expenses reasonably incurred by them or any of
them in connection with investigating or defending any actions whether or not resulting in any
liability, insofar as such losses, claims, damages, expenses or liabilities (or actions,
proceedings or settlements in respect thereof) arise out of or are based upon any of the following
statements, omissions or violations (collectively a “Violation”): (i) any untrue statement
or alleged untrue statement of any material fact contained in the registration statement, any
filing with any state or federal securities commission or agency or any prospectus, offering
circular or other document incident to such registration (including any related notification,
registration statement under which such Registrable Securities were registered under the Securities
Act pursuant to Sections 2, 3 or 4, any preliminary prospectus or final prospectus contained
therein, or any amendment or supplement thereof), (ii) any blue sky application or other document
executed by the Company specifically for that purpose or based upon written information furnished
by the Company filed in any state or other jurisdiction in order to qualify any or all of the
Registrable
Securities under the securities laws thereof (any such application, document or information
herein called a “Blue Sky Application”), (iii) any omission or alleged omission to state in
any such registration statement, prospectus, amendment or supplement or in any Blue Sky
Applications

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executed or filed by the Company, a material fact required to be stated therein or
necessary to make the statements therein not misleading, (iv) any violation by the Company or its
agents of the Securities Act or any rule or regulation promulgated under the Securities Act
applicable to the Company or its agents and relating to action or inaction required of the Company
in connection with such registration, or (v) any failure to register or qualify the Registrable
Securities in any state where the Company or its agents has affirmatively undertaken or agreed in
writing that the Company (the undertaking of any underwriter chosen by the Company being attributed
to the Company) will undertake such registration or qualification (provided that in such instance
the Company shall not be so liable if it has used its best efforts to so register or qualify the
Registrable Securities) and will reimburse each such holder, and such officer, director and
partner, each such underwriter and each such controlling person for any legal or other expenses
reasonably incurred by them in connection with investigating or defending any such loss, claim,
damage, liability or action, promptly after being so incurred; provided, however,
that the indemnity agreement contained in this subsection 1.10(a) shall not apply to amounts paid
in settlement of any such loss, claim, damage or liability (or actions, proceedings or settlements
in respect thereof) if such settlement is effected without the consent of the Company (which
consent shall not be unreasonably withheld), nor shall the Company be liable to any Holder, each of
its officers, directors, partners, members, underwriter or controlling person for any such loss,
claim, damage or liability (or actions, proceedings or settlements in respect thereof), to the
extent that it arises out of or is based upon a Violation which occurs in reliance upon and in
conformity with written information furnished expressly for use in connection with such
registration by any such Holder, each of its officers, directors, partners, members, underwriter or
controlling person.

               (b) To the extent permitted by law, each selling Holder will indemnify and hold harmless the
Company, each of its directors, each of its officers who has signed the registration statement,
each person, if any, who controls the Company within the meaning of the Securities Act, any
underwriter, any other Holder selling securities in such registration statement and any controlling
person of any such underwriter or other Holder, against any losses, claims, damages or liabilities
(or actions, proceedings or settlements in respect thereof), whether joint or several, to which any
of the foregoing persons may become subject, under the Securities Act, the Exchange Act or other
federal or state law, insofar as such losses, claims, damages or liabilities (or actions,
proceedings or settlements in respect thereof) arise out of or are based upon any Violation, in
each case to the extent (and only to the extent) that such Violation occurs in reliance upon and in
conformity with written information furnished by such Holder expressly for use in connection with
such registration; and each such Holder will pay, as incurred, any legal or other expenses
reasonably incurred by any person intended to be indemnified pursuant to this subsection 1.10(b),
in connection with investigating or defending any such loss, claim, damage, expenses or liability
(or actions, proceedings or settlement in respect thereof); provided, however, that
the indemnity agreement contained in this subsection 1.10(b) shall not apply to amounts paid in
settlement of any such loss, claim, damage, expenses or liability (or actions, proceedings or
settlements in respect thereof) if such settlement is effected without the consent of the Holder,
which consent shall not be unreasonably withheld; provided, that in no event shall
any indemnity under this subsection 1.10(b) exceed the net proceeds from the offering received
by such Holder, except in the case of willful fraud by such Holder.

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               (c) Promptly after receipt by an indemnified party under this Section 1.10 of notice of
the
commencement of any action (including any governmental action), such indemnified party will, if a
claim in respect thereof is to be made against any indemnifying party under this Section 1.10,
deliver to the indemnifying party a written notice of the commencement thereof and the indemnifying
party shall have the right to participate in, and, to the extent the indemnifying party so desires,
jointly with any other indemnifying party similarly noticed, to assume the defense thereof with
counsel mutually satisfactory to the parties; provided, however, that an
indemnified party (together with all other indemnified parties which may be represented without
conflict by one counsel) shall have the right to retain one separate counsel, with the reasonable
fees and expenses to be paid by the indemnifying party, if representation of such indemnified party
by the counsel retained by the indemnifying party would be inappropriate due to actual or potential
differing interests between such indemnified party and any other party represented by such counsel
in such proceeding. The failure to deliver written notice to the indemnifying party within a
reasonable time of the commencement of any such action shall not relieve the indemnifying party
from any liability which it may have to such indemnified party other than under this Section 1.10
and shall only relieve it from any liability which it may have to such indemnified party under this
Section 1.10 if and to the extent the indemnifying party is prejudiced by such omission.

               (d) If the indemnification provided for in this Section 1.10 is held by a court of
competent
jurisdiction to be unavailable to an indemnified party with respect to any loss, liability, claim,
damage or expense referred to therein, then the indemnifying party, in lieu of indemnifying such
indemnified party hereunder, shall contribute to the amount paid or payable by such indemnified
party as a result of such loss, liability, claim, damage, or expense in such proportion as is
appropriate to reflect the relative fault of the indemnifying party on the one hand and of the
indemnified party on the other in connection with the statements or omissions that resulted in such
loss, liability, claim, damage or expense as well as any other relevant equitable considerations;
provided, that in no event shall any contribution by a Holder under this Subsection 1.10(d)
exceed the net proceeds from the offering received by such Holder, except in the case of willful
fraud by such Holder. The relative fault of the indemnifying party and of the indemnified party
shall be determined by reference to, among other things, whether the untrue or alleged untrue
statement of a material fact or the omission to state a material fact relates to information
supplied by the indemnifying party or by the indemnified party and the parties’ relative intent,
knowledge, access to information, and opportunity to correct or prevent such statement or omission.

               (e) Notwithstanding the foregoing, to the extent that the provisions on indemnification and
contribution contained in the underwriting agreement entered into in connection with the
underwritten public offering are in conflict with the foregoing provisions, the provisions in the
underwriting agreement shall control.

               (f) The obligations of the Company and Holders under this Section 1.10 shall survive the
completion of any offering of Registrable Securities in a registration statement under this Section
1, and otherwise.

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          1.11 Reports Under Securities Exchange Act of 1934. With a view to making available
to the Holders the benefits of Rule 144 promulgated under the Securities Act and any other rule or
regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the
public without registration or pursuant to a registration on Form S-3, the Company agrees to:

               (a) make and keep public information available, as those terms are understood and defined in
SEC Rule 144, at all times after the effective date of the first registration statement filed by
the Company for the offering of its securities to the general public so long as the Company remains
subject to the periodic reporting requirements under Sections 13 or 15(d) of the Exchange Act;

               (b) take such action, including the voluntary registration of its Common Stock under Section
12 of the Exchange Act, as is necessary to enable the Holders to utilize Form S-3 for the sale of
their Registrable Securities, such action to be taken as soon as practicable after the end of the
fiscal year in which the first registration statement filed by the Company for the offering of its
securities to the general public is declared effective;

               (c) file with the SEC in a timely manner all reports and other documents required of the
Company under the Securities Act and the Exchange Act;

               (d) furnish to any Holder, so long as the Holder owns any Registrable Securities, forthwith
upon request (i) a written statement by the Company that it has complied with the reporting
requirements of SEC Rule 144, the Securities Act and the Exchange Act (at any time after it has
become subject to such reporting requirements), or that it qualifies as a registrant whose
securities may be resold pursuant to Form S-3 (at any time after it so qualifies), (ii) a copy of
the most recent annual or quarterly report of the Company and such other reports and documents so
filed by the Company, and (iii) such other information as may be reasonably requested in availing
any Holder of any rule or regulation of the SEC which permits the selling of any such securities
without registration or pursuant to such form; and

               (e) after the occurrence of its initial public offering, the Company shall facilitate and
expedite transfers of the Registrable Securities pursuant to Rule 144, which efforts shall include
timely notice to the Company’s transfer agent to expedite such transfers of Registrable Securities.

          1.12 Assignment of Registration Rights. The rights to cause the Company to register
Registrable Securities pursuant to this Section 1 may be assigned (but only with all related
obligations) by a Holder to (i) any of its affiliates, (ii) any partners or retired partners of a
transferring Holder that is a partnership or the members of a transferring Holder that is a limited
liability company, (iii) any family member or trust for the benefit of any individual Holder, or
(iv) a transferee or assignee of at least 1,000,000 shares of such securities (or all of such
Holder’s
shares, if less than 1,000,000 shares), provided the Company is, within a reasonable
time after such transfer, furnished with written notice of the name and address of such transferee
or assignee and the securities with respect to which such registration rights are being assigned;
and provided, further, that such assignment shall be effective only if immediately
following such transfer the further disposition of such securities by the transferee or assignee is
restricted under

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the Securities Act. For the purposes of determining the number of shares of
Registrable Securities held by a transferee or assignee, the holdings of transferees and assignees
of a partnership who are partners or retired partners of such partnership (including spouses and
ancestors, lineal descendants and siblings of such partners or spouses who acquire Registrable
Securities by gift, will or intestate succession) shall be aggregated together and with the
partnership; provided that all assignees and transferees who would not qualify individually
for assignment of registration rights shall have a single attorney-in-fact for the purpose of
exercising any rights, receiving notices or taking any action under Section 1.

          1.13 Limitations on Subsequent Registration Rights. From and after the date of this
Agreement, the Company shall not, without the prior written consent of the Holders of a majority of
the outstanding Senior Registrable Securities, enter into any agreement with any holder or
prospective holder of any securities of the Company which would allow such holder or prospective
holder (a) to include such securities in any registration filed under Section 1.2 hereof, unless
under the terms of such agreement, such holder or prospective holder may include such securities in
any such registration only to the extent that the inclusion of his securities will not reduce the
amount of the Registrable Securities of the Holders which are included or (b) to make a demand
registration.

          1.14 “Market Stand-Off” Agreement.

               (a) Market-Standoff Period; Agreement. In connection with the initial
public offering
of the Company’s securities and upon request of the Company or the underwriters managing such
offering of the Company’s securities, each Holder agrees not to sell, make any short sale of, loan,
grant any option for the purchase of, or otherwise dispose of any securities of the Company,
however or whenever acquired (other than those included in the registration) without the prior
written consent of the Company or such underwriters, as the case may be, for such period of time
(not to exceed 180 days) from the effective date of such registration as may be requested by the
Company or such managing underwriters and to execute an agreement reflecting the foregoing as may
reasonably be requested by the underwriters at the time of the Company’s initial public offering.

               (b) Limitations. The obligations described in Section 1.14(a) shall
apply only if all
officers and directors of the Company and all other holders of 1% or more, beneficially or of
record, of the outstanding shares of capital stock of the Company enter into similar agreements,
and shall not apply to a registration relating solely to employee benefit plans, or to a
registration relating solely to a transaction pursuant to Rule 145 under the Securities Act.

               (c) Stop-Transfer Instructions. In order to enforce the foregoing
covenants, the
Company may impose stop-transfer instructions with respect to the securities of
each Holder (and the securities of every other person subject to the restrictions in Section
1.14(a)).

               (d) Transferees Bound. Each Holder agrees that it will not transfer
securities of the
Company unless each transferee agrees in writing to be bound by all of the provisions of this
Section 1.14, provided that this Section 1.14(d) shall not apply to transfers pursuant to a
registration statement.

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          1.15 Termination of Registration Rights. No Holder shall be entitled to exercise any
right provided for in this Section 1 if all the Registrable Securities held by such Holder are
eligible for distribution to the public pursuant to Rule 144(k) or all (but not less than all) of
such Registrable Securities are eligible for distribution to the public at one time pursuant to the
other provisions of Rule 144 without violation of the applicable volume limitations and such Holder
owns less than 1% of the outstanding capital stock of the Company. In any event, the provisions of
this Section 1 shall terminate on the date which is five years after the consummation of a
Qualified IPO.

     2. Covenants of the Company.

          2.1 Delivery of Financial Statements. The Company shall deliver to each Holder of at
least 1,000,000 shares of Registrable Securities (other than a Holder in good faith deemed by the
Board of Directors of the Company to be a competitor of the Company) (each an “Eligible
Holder”):

               (a) as soon as practicable, but in any event within 90 days after the end of each fiscal
year
of the Company, an income statement for such fiscal year, a balance sheet of the Company and
statement of stockholder’s equity as of the end of such year, and a statement of cash flows for
such year, such year-end financial reports to be in reasonable detail, prepared in accordance with
generally accepted accounting principles (“GAAP”), and audited and certified by an
independent public accounting firm of nationally recognized standing selected by the Company;

               (b) as soon as practicable, but in any event within 30 days after the end of each of the
first
three quarters of each fiscal year of the Company, an unaudited profit or loss statement, a
statement of cash flows for such fiscal quarter and an unaudited balance sheet as of the end of
such fiscal quarter;

               (c) as soon as practicable, but in any event within 30 days after the end of each month,
an
unaudited income statement and a statement of cash flows and balance sheet for and as of the end of
such month;

               (d) an annual budget and operating plan each fiscal year, promptly after management has
presented such budget and operating plan to the Board, no later than 30 days prior to the preceding
year end;

               (e) promptly upon receipt or publication thereof, any written reports submitted to the Company
by independent public accountants in connection with an annual or interim audit of the books of the
Company made by such accountants;

               (f) such other information relating to the financial condition, business, prospects or
corporate affairs of the Company as any Eligible Holder may from time to time reasonably request in
writing; provided, however, that the Company shall not be obligated pursuant to this Section 2.1(e)
to provide any information that it reasonably considers to be a trade secret or similar
confidential information unless such Eligible Holder executes a non-disclosure agreement reasonably
acceptable to the Company with respect to such information.

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The right to delivery of financial statements set forth in this Section 2.1 may be amended or
waived in writing by the Eligible Holders of at least 60% of the Eligible Holders’ outstanding
Registrable Securities.

          2.2 Inspection. The Company shall permit each Eligible Holder at such Eligible
Holder’s expense, to visit and inspect the Company’s properties, to examine its books of account
and records and make copies or extracts thereof and to discuss the Company’s affairs, finances and
accounts with its officers, directors, key employees and accountants, all at such reasonable times
as may be requested by the Investor; provided, however, that the Company shall not
be obligated pursuant to this Section 2.2 to provide access to any information which it reasonably
considers to be a trade secret or similar confidential information unless such Eligible Holder
executes a non-disclosure agreement reasonably acceptable to the Company. The right of inspection
set forth in this Section 2.2 may be amended or waived in writing by the Eligible Holders of at
least 60% of the Eligible Holders’ outstanding Registrable Securities.

          2.3 Right of First Offer. Subject to the terms and conditions specified in this
Section 2.3, the Company hereby grants to each Major Investor (as hereinafter defined) a right of
first offer with respect to future issuances and sales by the Company of its Shares (as hereinafter
defined). For purposes of this Section 2.3, a “Major Investor” shall mean any person who
holds, along with its affiliates, at least 1,000,000 shares of Preferred Stock (or the Common Stock
issued upon conversion thereof). For purposes of this Section 2.3, Major Investor includes any
general partners and affiliates of a Major Investor. A Major Investor who chooses to exercise the
right of first offer may designate as purchasers under such right itself or its partners or
affiliates in such proportions as it deems appropriate.

          Each time the Company proposes to offer any shares of, or securities convertible into or
exercisable for any shares of, any class of its capital stock (“Shares”), the Company shall
first make an offering of such Shares to each Major Investor in accordance with the following
provisions:

               (a) The Company shall deliver a notice by certified mail (“Notice”) to the
Major
Investors stating (i) its bona fide intention to offer such Shares, (ii) the number of such Shares
to be offered, and (iii) the price and terms, if any, upon which it proposes to offer such Shares.

               (b) Within 20 calendar days after delivery of the Notice, the Major Investor may elect to
purchase or obtain, at the price and on the terms specified in the Notice, up to that portion of
such Shares which equals the proportion that the number of shares of Common Stock issued and held,
or issuable upon conversion and exercise of all then convertible or exercisable securities then
held, by such Major Investor bears to the total number of shares of Common Stock then outstanding
(assuming full conversion and exercise of all convertible or exercisable securities). Such
purchase shall be completed at the same closing as that of any third party purchasers or at an
additional closing thereunder. The Company shall promptly, in writing, inform each Major Investor
that purchases all the shares available to it (each, a “Fully-Exercising Investor”) of any
other Major Investor’s failure to do likewise. During the ten-day period commencing after receipt
of such information, each Fully-Exercising Investor shall be entitled to obtain that portion of the
Shares for which Major Investors were entitled to subscribe but which

-16-

 

were not subscribed for by
the Major Investors that is equal to the proportion that the number of shares of Common Stock
issued and then held, or issuable upon conversion and exercise of all then convertible or
exercisable securities then held, by such Fully-Exercising Investor bears to the total number of
shares of Common Stock then outstanding (assuming full conversion and exercise of all then
convertible or exercisable securities) and held by all the Fully-Exercising Investors.

               (c) The Company may, during the 90-day period following the last expiration of the last period
provided in subsection 2.3(b) hereof, offer and sell the remaining unsubscribed portion of the
Shares to any person or persons at a price not less than, and upon terms no more favorable to the
offeree than those specified in the Notice. If the Company does not sell such unsubscribed Shares
within such period, the right provided hereunder shall be deemed to be revived and such Shares
shall not be offered unless first reoffered to the Major Investors in accordance herewith.

               (d) The right of first offer in this paragraph 2.3 shall not be applicable to:

                    (i) a split or subdivision of the outstanding shares of capital
stock, or a dividend or other
distribution payable in additional shares of capital stock or other securities or rights
convertible into, or entitling the holder thereof to receive directly or indirectly, additional
shares of capital stock without payment of any consideration by such holder for the additional
shares of capital stock (including the additional shares of Common Stock issuable upon conversion
or exercise thereof),

                    (ii) Up to an aggregate of 14,103,928 shares of Common Stock
issuable or heretofore issued to
employees, consultants or directors of the Company directly or pursuant to a stock option plan,
restricted stock plan or other agreement approved by the Board (or such higher number of shares as
shall be approved unanimously by the Board),

                    (iii) Capital stock, or options or warrants to purchase capital
stock, issued to financial
institutions or lessors in connection with commercial credit arrangements, real estate leases,
equipment financings or similar transactions, each of which has
been approved by the Board (including a majority of the Directors elected by the holders of
the Preferred Stock),

                    (iv) Capital stock or warrants or options to purchase capital
stock issued in connection with
bona fide acquisitions, mergers or similar transactions, each of which has been approved by the
Board (including a majority of the Directors elected by the holders of the Preferred Stock),

                    (v) Capital stock or warrants or options to purchase capital
stock issued in connection with
bona fide strategic partnerships or licenses or acquisition of third party technology, each of
which has been approved by the Board (including a majority of the Directors elected by the holders
of the Preferred Stock),

-17-

 

                    (vi) Shares of Common Stock issued or issuable upon conversion of
the Preferred Stock and upon
conversion or exercise of outstanding options, warrants, convertible notes or other convertible
securities outstanding as of the date of this Agreement,

                    (vii) Shares of Common Stock issued or issuable with the
affirmative vote or written consent
of (i) at least 60% of the then outstanding shares of Series A Preferred Stock, Series B Preferred
Stock, Series C Preferred Stock and Series D Preferred Stock, voting together as a single class and
(ii) at least 66-2/3% of the then outstanding shares of Series C Preferred Stock and Series D
Preferred Stock, voting together as a single class, or

                    (iix) Shares of Common Stock issued pursuant to a Qualified IPO.

In addition to the foregoing, the right of first offer in this paragraph 2.3 shall not be
applicable with respect to any Major Investor and any subsequent securities issuance, if (i) at the
time of such subsequent securities issuance, the Major Investor is not an “accredited investor,” as
that term is then defined in Rule 501(a) under the Securities Act, or is not otherwise qualified to
participate in an offering exempt from registration under the Securities Act; and (ii) such
subsequent securities issuance is otherwise being offered only to accredited investors.

The right of first offer set forth in this Section 2.3 may be amended or waived in writing by Major
Investors holding at least 60% of the outstanding Major Investors’ Registrable Securities.

          2.4 Qualified Small Business Stock Status. The Company shall submit to the Investors
and to the Internal Revenue Service any reports that may be required under Section 1202(d)(1)(C) of
the Code and any related Treasury Regulations. In addition, within ten (10) days after any
Investor has delivered to the Company a written request therefor, the Company shall deliver to such
Investor a written statement informing the Investor whether, in the Company’s good-faith judgment,
such Investor’s interest in the Company constitutes “qualified small business stock” as defined in
Section 1202(c) of the Code. The Company’s obligation to furnish a written statement pursuant to
this Section 2.4 shall continue notwithstanding the fact that a class of the Company’s stock may be
traded on an established securities market.

          2.5 Audit. The Company shall permit, shall cooperate with and instruct each of its
employees, consultants and outside auditors to cooperate with, and shall supply all such
information as may be reasonably requested in connection with, an audit of the Company conducted on
behalf of, at the expense of, and by auditors engaged by, any holder of Series C Preferred Stock
holding at least 1,000,000 shares of Common Stock (assuming the conversion into Common Stock of all
Preferred stock held by such holder) who requests the same in writing; provided,
however, that the Company shall not be obligated pursuant to this Section 2.5 in connection
with such an audit on behalf of the same holder of Series C Preferred Stock more than once in any
twelve month period.

          2.6 Director and Officer Insurance. The Company shall use commercially reasonable
efforts to obtain and maintain in full force and effect director and officer insurance

-18-

 

which
provides a minimum of $1,000,000 in coverage provided that such coverage is available at
commercially acceptable terms, as determined by the Board of Directors.

          2.7 Non-disclosure and Developments. The Company shall cause all technological
developments, patentable or unpatentable inventions, discoveries or improvements by the Company’s
or any subsidiary’s officers or employees to be documented in accordance with the appropriate
professional standards, cause all officers and key employees and consultants of the Company or any
subsidiary, to execute confidentiality and assignment of inventions agreements in a form agreed
upon by the Board of Directors in favor of the Company or such subsidiary and to file and prosecute
United States and foreign patent or copyright applications relating to and protecting such
developments on behalf of the Company or such subsidiary.

          2.8 Termination of Covenants. The covenants set forth in Sections 2.1 through 2.7
shall terminate as to each Holder and be of no further force or effect immediately upon the
consummation of a Qualified IPO.

     3. Miscellaneous.

          3.1 Successors and Assigns. Except as otherwise provided in this Agreement, the terms
and conditions of this Agreement shall inure to the benefit of and be binding upon the respective
permitted successors and assigns of the parties (including transferees of any of the Preferred
Stock or any Common Stock issued upon conversion thereof). Nothing in this Agreement, express or
implied, is intended to confer upon any party other than the parties hereto or their respective
successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this
Agreement, except as expressly provided in this Agreement.

          3.2 Amendments and Waivers. Except as set forth in Sections 2.1, 2.2 and 2.3 any term
of this Agreement may be amended or waived only with the written consent of the Company, the
holders of a majority of the Registrable Securities then outstanding; provided, that any amendment
that alters, changes, amends or modifies or adversely affects, directly or indirectly, the rights
of the holders of Senior Registrable Shares shall require the written consent of the holders of at
least two-thirds of the Senior Registrable Shares. Notwithstanding the foregoing, this Agreement
may be amended only with the written consent of the Company for the sole purpose of including
additional purchasers of Series D Preferred Stock as “Investors” and
“Holders”. Any amendment or waiver effected in accordance with this paragraph shall be
binding upon each party to the Agreement, whether or not such party has signed such amendment or
waiver, each future holder of all such Registrable Securities, and the Company; provided, however,
in the event that any amendment, supplement, modification, waiver or consent would adversely change
a specifically enumerated right or obligation hereunder of one or more parties hereto (the
“Adversely Affected Parties”) in a way that is adverse to the Adversely Affected Parties
and in a manner different from the manner in which such specifically enumerated right or obligation
is changed with respect to other parties hereto, such amendment or waiver shall also require the
written consent of each such Adversely Affected Party.

          3.3 Notices. Unless otherwise provided, any notice required or permitted by this
Agreement shall be in writing and shall be deemed sufficient upon delivery, when delivered
personally or by overnight courier or sent by telegram or fax, or forty-eight (48) hours after

-19-

 

being deposited in the U.S. mail, as certified or registered mail, with postage prepaid, and
addressed to the party to be notified at such party’s address or fax number as set forth on
Exhibit A hereto or as subsequently modified by written notice.

          3.4 Severability. If one or more provisions of this Agreement are held to be
unenforceable under applicable law, the parties agree to renegotiate such provision in good faith.
In the event that the parties cannot reach a mutually agreeable and enforceable replacement for
such provision, then (a) such provision shall be excluded from this Agreement, (b) the balance of
the Agreement shall be interpreted as if such provision were so excluded and (c) the balance of the
Agreement shall be enforceable in accordance with its terms.

          3.5 Governing Law. This Agreement and all acts and transactions pursuant hereto shall
be governed, construed and interpreted in accordance with the laws of the State of Delaware,
without giving effect to principles of conflicts of laws.

          3.6 Damages. The Company recognizes and agrees that the holder of Registrable
Securities will not have an adequate remedy if the Company fails to comply with this Agreement and
that damages may not be readily ascertainable, and the Company expressly agrees that, in the event
of such failure, it shall not oppose an application by the holder of Registrable Securities or any
other person entitled to the benefits of this Agreement requiring specific performance of any and
all provisions hereof or enjoining the Company from continuing to commit any such breach of this
Agreement.

          3.7 Counterparts. This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute one and the same
instrument.

          3.8 Titles and Subtitles. The titles and subtitles used in this Agreement are used
for convenience only and are not to be considered in construing or interpreting this Agreement.

          3.9 Aggregation of Stock. All shares of the Preferred Stock and Registrable
Securities held or acquired by affiliated entities or persons shall be aggregated together for the
purpose of determining the availability of any rights under this Agreement.

          3.10 Additional Parties. The Investors agree that, upon delivery of counterpart
signature pages to this Agreement, any additional persons who become “Purchasers” pursuant to the
Series D Purchase Agreement shall become “Investors” under this Agreement without further action by
any other Investor.

          3.11 Consent and Waiver of Existing Investors. The undersigned constitute Holders of
a majority of the Registrable Securities outstanding pursuant to the Second Amended Agreement, and,
pursuant to Section 3.3 of the Second Amended Agreement, hereby consent to (a) the grant of
registration rights contemplated herein, (b) the waiver of the Right of First Offer as set forth in
Section 2.2 of the Second Amended Agreement with respect to the issuance of shares of Series D
Preferred Stock pursuant to the Series D Purchase Agreement, (c) the waiver

-20-

 

of any notice
requirements as set forth in the Second Amended Agreement and (d) the amendment and replacement of
the Second Amended Agreement by this Agreement.

          3.12 Calculation of Holdings.

               (a) For the purpose of determining the availability of any right or the applicability of any
limitation hereunder, all shares of Preferred Stock and Common Stock held by H&Q Life Sciences
Investors and H&Q Healthcare Investors and any affiliated funds controlling, controlled by or under
common control thereof, shall, in the sole discretion of H&Q Life Sciences Investors and H&Q
Healthcare Investors, be aggregated, and H&Q Life Sciences Investors and H&Q Healthcare Investors
and affiliated funds controlling, controlled by or under common control thereof shall be deemed to
be a single Investor.

               (b) For the purpose of determining the availability of any right or the applicability of any
limitation hereunder, all shares of Preferred Stock and Common Stock held by ProQuest Investments
II, L.P. and ProQuest Investments II Advisors Fund, L.P. and any affiliated funds controlling,
controlled by or under common control thereof, shall in the sole discretion of ProQuest Investments
II, L.P. and ProQuest Investments II Advisors Fund, L.P., be aggregated and ProQuest Investments
II, L.P. and ProQuest Investments II Advisors Fund, L.P. and any affiliated funds controlling,
controlled by or under common control thereof, shall be deemed to be a single Investor.

               (c) For the purpose of determining the availability of any right or the applicability of any
limitation hereunder, all shares of Preferred Stock and Common Stock held by Oxford Bioscience
Partners IV, L.P. and any affiliated funds controlling, controlled by or under common control
thereof, shall in the sole discretion of Oxford Bioscience Partners IV, L.P., be aggregated and
Oxford Bioscience Partners IV, L.P. and any affiliated funds controlling, controlled by or under
common control thereof, shall be deemed to be a single Investor.

               (d) For the purpose of determining the availability of any right or the applicability of any
limitation hereunder, all shares of Preferred Stock and Common Stock held
by Schroder Ventures International Life Sciences Fund III (LP1), L.P. and any affiliated funds
controlling, controlled by or under common control thereof, shall in the sole discretion of
Schroder Ventures International Life Sciences Fund III (LP1), L.P., be aggregated and Schroder
Ventures International Life Sciences Fund III (LP1), L.P. and any affiliated funds controlling,
controlled by or under common control thereof, shall be deemed to be a single Investor.

               (e) For the purpose of determining the availability of any right or the applicability of any
limitation hereunder, all shares of Preferred Stock and Common Stock held by Montagu Newhall
Associates, Inc. and any affiliated funds controlling, controlled by or under common control
thereof, shall in the sole discretion of Montagu Newhall Associates, Inc., be aggregated and
Montagu Newhall Associates, Inc. and any affiliated funds controlling, controlled by or under
common control thereof, shall be deemed to be a single Investor.

[Signature Pages Follow]

-21-

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	COMPANY:
	 
	 	 	 	 	 	 
	 	 	CONCENTRIC MEDICAL, INC.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Gary A. Curtis	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Gary A. Curtis, President and Chief	 	 
	 

	 	 	 	Executive Officer	 	 
	 
	 	 	 	 	 	 
	 	 	Address: 1380 Shorebird Way	 	 
	 	 	                Mountain View, CA 94043	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	Montagu Newhall Global Partners II, LP	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ C. Aston Newhall	 	 
	 

	 	 	 	 	 	 
	 	 	Name: C. Aston Newhall	 	 
	 	 	Title: General Partner	 	 
	 
	 	 	 	 	 	 
	 	 	Montagu Newhall Global Partners II-A, LP	 	 
	 
	 	 	 	 	 	 
	 	 	By: /s/ C. Aston Newhall	 	 
	 

	 	 	 	 	 	 
	 	 	Name: C. Aston Newhall	 	 
	 	 	Title: General Partner	 	 
	 
	 	 	 	 	 	 
	 	 	Montagu Newhall Global Partners II-B, LP	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ C. Aston Newhall	 	 
	 

	 	 	 	 	 	 
	 	 	Name: C. Aston Newhall	 	 
	 	 	Title: General Partner	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	Prothro Family Limited Partnership, LTD.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ J.H. Cullum Clark	 	 
	 

	 	 	 	 	 	 
	 	 	Name: J.H. Cullum Clark	 	 
	 	 	Title: Managing General Partner	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	Faison DuBose Bohlayer Charitable Remainder Trust	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Edward M. Bradley	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Edward M. Bradley	 	 
	 	 	Title: Trustee	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	Red Abbey Venture Partners (QP), LP	 	 
	 	 	By: Red Abbey Venture Partners, LLC, its General Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Matt Zuga	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Matt Zuga	 	 
	 	 	Title: Managing Member	 	 
	 
	 	 	 	 	 	 
	 	 	Red Abbey Venture Partners, LP	 	 
	 	 	By: Red Abbey Venture Partners, LLC, its General Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Matt Zuga	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Matt Zuga	 	 
	 	 	Title: Managing Member	 	 
	 
	 	 	 	 	 	 
	 	 	Red Abbey CEO’s Fund, LP	 	 
	 	 	By: Red Abbey Venture Partners, LLC, its General Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Matt Zuga	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Matt Zuga	 	 
	 	 	Title: Managing Member	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	Merifin Capital NV	 	 
	 	 	By: FINABEL S.A., Managing Director	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Jacqueline Curzon	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Jacqueline Curzon, Director	 	 
	 

	 	Title:	 	 	 	 
	 

	 	 	 	 	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	Lighthouse Capital Partners V, L.P.	 	 
	 

	 	By:
	 	Lighthouse Management Partners V, L.L.C.,	 	 
	 

	 	 	 	its general partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Title:	 	 	 	 
	 

	 	 	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	Lighthouse Capital Partners IV, L.P.	 	 
	 

	 	By:
	 	Lighthouse Management Partners IV, L.L.C.,	 	 
	 

	 	 	 	its general partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Title:	 	 	 	 
	 

	 	 	 	 	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	Oxford Bioscience Partners IV L.P.	 	 
	 	 	By: OBP Management IV L.P.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Michael Lytton	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Michael Lytton – General Partner	 	 
	 
	 	 	 	 	 	 
	 	 	MRNA Fund II L.P.	 	 
	 	 	By: OBP Management IV L.P.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Michael Lytton	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Michael Lytton – General Partner	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	INTERNATIONAL LIFE SCIENCES FUND III (LP1),
L.P., by: International Life Sciences Fund III (GP),
L.P., its sole General Partner, by: ILSF III, LLC,
its sole General Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Nick Coleman	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Nick Coleman	 	 
	 	 	Title: Member, ILSF III LLC	 	 
	 
	 	 	 	 	 	 
	 	 	INTERNATIONAL LIFE SCIENCES FUND III (LP2), L.P., by:
International Life Sciences Fund III (GP), L.P., its
sole General Partner, by: ILSF III, LLC, its sole
General Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Nick Coleman	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Nick Coleman	 	 
	 	 	Title: Member, ILSF III LLC	 	 
	 
	 	 	 	 	 	 
	 	 	INTERNATIONAL LIFE SCIENCES FUND III CO-INVESTMENT,
L.P., by: International Life Sciences Fund III (GP),
L.P., its sole General Partner, by: ILSF III, LLC,
its sole General Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Nick Coleman	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Nick Coleman	 	 
	 	 	Title: Member, ILSF III LLC	 	 
	 
	 	 	 	 	 	 
	 	 	INTERNATIONAL LIFE SCIENCES FUND III STRATEGIC
PARTNERS, L.P., by: International Life Sciences Fund
III (GP), L.P., its sole General Partner, by: ILSF
III, LLC, its sole General Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Nick Coleman	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Nick Coleman	 	 
	 	 	Title: Member, ILSF III LLC	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as
of the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	H&Q Healthcare Investors	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Daniel R. Omstead	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Daniel R. Omstead	 	 
	 	 	Title: President	 	 
	 
	 	 	 	 	 	 
	 	 	The name H&Q Healthcare Investors is the
designation of the Trustees for the time being under
an Amended and Restated Declaration of Trust dated
April 12, 1987, as amended, and all persons dealing
with H&Q Healthcare Investors must look solely to the
trust property for the enforcement of any claim
against H&Q Healthcare Investors, as neither the
Trustees, officers nor shareholders assume any
personal liability for the obligations entered into
on behalf of H&Q Healthcare Investors.	 	 
	 
	 	 	 	 	 	 
	 	 	H&Q Life Sciences Investors	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Daniel R. Omstead	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Daniel R. Omstead	 	 
	 	 	Title: President	 	 
	 
	 	 	 	 	 	 
	 	 	The name H&Q Life Sciences Investors is the
designation of the Trustees for the time being under
a Declaration of Trust dated February 20, 1992, as
amended, and all persons dealing with H&Q Life
Sciences Investors must look solely to the trust
property for the enforcement of any claim against H&Q
Life Sciences Investors, as neither the Trustees,
officers nor shareholders assume any personal
liability for the obligations entered into on behalf
of H&Q Life Sciences Investors.	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as
of the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	ProQuest Investments II, L.P.	 	 
	 	 	By: ProQuest Associates II, LLC	 	 
	 

	 	 	 	Its General Partner	 	 
	 	 	By: Chief Financial Officer	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Pasquale DeAngelis	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Pasquale DeAngelis	 	 
	 
	 	 	 	 	 	 
	 	 	ProQuest Investments II Advisors Fund, L.P.	 	 
	 	 	By: ProQuest Associates II, LLC	 	 
	 

	 	 	 	Its General Partner	 	 
	 	 	By: Chief Financial Officer	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Pasquale DeAngelis	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Pasquale DeAngelis	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	New Enterprise Associates VIII, Limited Partnership	 	 
	 

	 	By:
	 	NEA Partners VIII, Limited Partnership	 	 
	 

	 	 	 	its General Partner	 	 
	 

	 	By:
	 	General Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Charles W. Newhall, III	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Charles W. Newhall, III	 	 
	 	 	Title: General Partner	 	 
	 
	 	 	 	 	 	 
	 	 	New Enterprise Associates 8A, Limited Partnership	 	 
	 

	 	By:
	 	NEA Partners 10, Limited Partnership	 	 
	 

	 	 	 	its General Partner	 	 
	 

	 	By:
	 	General Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Charles W. Newhall, III	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Charles W. Newhall, III	 	 
	 	 	Title: General Partner	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	NeuroVentures Fund, LP	 	 
	 	 	By NeuroVentures Capital LLC, its General Partner	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Daniel J. O’Connell	 	 
	 

	 	 	 	 	 	 
	 	 	Name: Daniel J. O’Connell	 	 
	 	 	Title: Managing Member	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as
of the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	New Venture Partners IV, L.P.	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ Howard D. Wolfe, Jr.	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	Howard D. Wolfe, Jr., General Partner	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	Glynn Ventures V	 	 
	 
	 	 	 	 	 	 
	 

	 	By:
	 	/s/ John W. Glynn	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	John W. Glynn, General Partner	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 
	 	INVESTORS:

 	 
	 	/s/ Andrew Chmyz
 	 
	 	Andrew Chmyz 	 
	 	 	 
	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 
	 	INVESTORS:

Gary A. Curtis, Trustee of The Gary A. Curtis Family

Trust dated July 4, 1991

 	 
	 	By:  	/s/ Gary A. Curtis
 	 
	 	 	Gary A. Curtis, Trustee 	 
	 	 	 	 
	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	/s/ Erik T. Engelson	 	 
	 	 	 	 	 
	 	 	Erik T. Engelson, Trustee of the Erik T.	 	 
	 	 	Engelson Trust UDT, dated March 29, 2000	 	 
	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	Robert Anderson	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	/s/ Ryan Drant	 	 
	 	 	 	 	 
	 	 	Ryan Drant	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	Kevin Knight	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	Frank Bonsal	 	 
	 
	 	 	 	 	 	 
	 	 	/s/ Martin Dieck	 	 
	 	 	 	 	 
	 	 	Martin Dieck	 	 
	 
	 	 	 	 	 	 
	 	 	/s/ Pierre Gobin	 	 
	 	 	 	 	 
	 	 	Pierre Gobin	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	Ivan Sepetka	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	William R. Brody	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	John Patrick Morris	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	Patricia F. Morris	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	Charles M. Strother	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	Thomas Anderson	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	Sandra Anderson	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	Jacques Dion	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	Paul Gobin	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	 	 	J. Casey McGlynn, Trustee of the Allan R.
Will and Heidi E. Will 1988 Irrevocable
Trust, U/A DTD 10/3/88	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

     The parties have executed this Third Amended and Restated Investors’ Rights Agreement as of
the date first above written.

	 	 	 	 	 	 	 
	 	 	INVESTORS:
	 
	 	 	 	 	 	 
	 	 	COMERICA INCORPORATED	 	 
	 
	 	 	 	 	 	 
	 

	 	By:	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Name:	 	 	 	 
	 

	 	 	 	 	 	 
	 

	 	Title:	 	 	 	 
	 

	 	 	 	 	 	 

SIGNATURE PAGE TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS

AGREEMENT

 

 

EXHIBIT A

INVESTORS

	 	 	 
	Oxford Bioscience Partners IV, L.P.

	 	Frank A. Bonsal, Jr.
	 
	 	 
	mRNA Fund II, L.P.

	 	Martin Dieck
	 
	 	 
	International Life Sciences Fund III
(LP1), L.P.

	 	Pierre Gobin
	 
	 	 
	International Life Sciences Fund III
(LP2), L.P.

	 	Ivan Sepetka
	 
	 	 
	International Life Sciences Fund III
Co-Investment, L.P.

	 	Robert Anderson
	 
	 	 
	International Life Sciences Fund III
Strategic Partners, L.P.

	 	William R. Brody
	 
	 	 
	H&Q Healthcare Investors

	 	John Patrick Morris & Patricia F. Morris
	 
	 	 
	H&Q Life Sciences Investors

	 	Charles M. Strother
	 
	 	 
	ProQuest Investments II, L.P.

	 	Thomas Anderson & Sandra Anderson
	 
	 	 
	ProQuest Investments II Advisors Fund, L.P.

	 	J. Casey McGlynn, Trustee of the Allan R.
Will and Heidi E. Will 1988 Irrevocable
Trust, U/A DTD 10/3/88
	 
	 	 
	New Enterprise Associates VIII, Limited
Partnership

	 	Jacques Dion
	 
	 	 
	New Enterprise Associates 8A, Limited
Partnership

	 	Paul Gobin
	 
	 	 
	New Venture Partners IV, L.P.

	 	Erik T. Engelson, Trustee of the Erik T.
Engelson Trust UDT, dated March 29, 2000
	 
	 	 
	NeuroVentures Fund, LP

	 	Glynn Ventures V
	 
	 	 
	Ryan Drant

	 	Kevin Knight
	 
	 	 
	Lighthouse Capital Partners V, L.P.

	 	Comerica Incorporated
	 
	 	 
	Lighthouse Capital Partners IV, L.P.

	 	Red Abbey Venture Partners (QP), LP
	 
	 	 
	Montagu Newhall Global Partners II, LP

	 	Red Abbey Venture Partners, LP
	 
	 	 
	Montagu Newhall Global Partners II-A, LP

	 	Red Abbey CEO’s Fund, LP
	 
	 	 
	Montagu Newhall Global Partners II-B, LP

	 	Merifin Capital NV
	 
	 	 
	Prothro Family Limited Partnership

	 	Gary A. Curtis, Trustee of The Gary A.
Curtis Family Trust dated July 4, 1991
	 
	 	 
	Faison DuBose Bohlayer Charitable
Remainder Trust

	 	Andrew Chmyz

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00128-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00128-of-00352.parquet"}]]