Document:

Exhibit 10.1

Exhibit 10.1

GUIDELINES FOR RESTRICTED STOCK UNITS

GRANTED UNDER THE

MARKETAXESS HOLDINGS INC. 2004 STOCK INCENTIVE PLAN

(Amended and Restated Effective as of April 28, 2006)

     Grants of Restricted Stock Units (as defined below) made on or following January 1, 2011 under
the MarketAxess Holdings Inc, 2004 Stock Incentive Plan (Amended and Restated Effective April 28,
2006) (the “Plan”) shall be subject to, and governed by, the provisions set forth in these
guidelines (“Guidelines”), the Plan and the applicable Award agreement. An Award of
Restricted Stock Units shall constitute an Other Stock-Based Award under the Plan. These
Guidelines have been adopted by the Committee pursuant to Section 3.3(a) of the Plan effective as
of January 1, 2011 and are part of the Plan.

1. Definitions. Unless otherwise indicated, any capitalized term used but not defined in
these Guidelines shall have the meaning ascribed to such term in the Plan. For purposes of these
Guidelines, the following definitions shall apply:

     1.1. “Deferral Eligible Participant” means either: (i) a Top Hat Employee; (ii) a
Consultant, or (iii) a Non-Employee Director, who, in each case, the Committee determines, in its
sole discretion, is eligible to defer payment of an RSU granted hereunder in accordance with
Section 4.

     1.2. “Restricted Stock Unit” or “RSU” means a restricted stock unit, which is
a unit of measurement equivalent to one share of Common Stock but with none of the attendant rights
of a holder of a share of Common Stock until a share of Common Stock is ultimately distributed in
payment of the obligation (other than the right to receive dividend equivalent amounts in
accordance with Section 5 hereof). Upon distribution, all vested RSUs shall be paid solely in the
form of shares of Common Stock.

     1.3. “Top Hat Employee” means an Eligible Employee who is a member of a select group
of management and highly compensated employees within the meaning of Sections 201(2), 301(a)(3) and
401(a)(1) of Employee Retirement Income Security Act of 1974, as amended (“ERISA”).

2. Eligibility. Any Eligible Employee, Consultant or Non-Employee Director who is
designated by the Committee is eligible to receive RSUs pursuant to these Guidelines.

3. Vesting of Stock Units and Payment.

     3.1. Except as otherwise provided in Section 3.3 hereof or in an Award agreement,

     (i) one-third (1/3) of an Award of RSUs shall vest on the date that is (as applicable,
the “Initial Vesting Date”):

(x) twelve (12) months after the grant date for an RSU that is (I) not a
Deferrable RSU (as defined in Section 4.1) or (II) a Deferrable RSU for
which the Participant made a deferral election

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in accordance with Section 4.2 prior to January 1 of the calendar in which
the grant of the RSU was made to the Participant, or

(y) thirteen (13) months after the grant date for an RSU that is a
Deferrable RSU for which the Participant did not make a deferral election
in accordance with Section 4.2 prior to January 1 of the calendar in which
the grant of the RSU was made to the Participant (regardless of whether
the Participant elects to defer such Award); and

     (ii) an additional one-third (1/3) of such Award of RSUs shall vest on each of the
second and third anniversaries of the grant date;

in each case, provided that the Participant has not had a Termination from the date of grant until
the applicable vesting date. Nothing herein shall be construed as prohibiting the Committee from
using an alternative vesting schedule at the time of grant of the RSU.

     3.2. Any alternative vesting schedule provided in an Award agreement with regard to Deferrable
RSUs for which the Participant did not make a deferral election in accordance with Section 4 prior
to January 1 of the calendar in which the grant of the RSU was made, shall provide for an Initial
Vesting Date that is no earlier than thirteen (13) months after the grant date.

     3.3. Notwithstanding Section 3.1 or any alternate vesting schedule set forth in an Award
agreement, unless otherwise set forth in an Award Agreement, upon the Participant’s death or
Disability on or following the grant date and prior to the applicable vesting date 50% of any RSUs
that are unvested on the date of the Participant’s death or Disability shall become immediately
vested.

     3.4. Notwithstanding Section 3.1 or any alternate vesting schedule set forth in an Award
agreement, unless otherwise set forth in an Award Agreement, in the event of a Change in Control,
RSUs granted under these Guidelines shall be treated in accordance with Section 12.1 of the Plan;
provided that, (i) any discretion exercisable by the Committee is limited to the extent required to
comply with Section 409A of the Code and any discretion exercised by the Committee as permitted
under these Guidelines and Section 12.1 of the Plan shall be exercised in a manner that is intended
not to cause such Award to be subject to any tax, interest or penalties that may be imposed on a
Participant under Section 409A of the Code without the Participant’s consent; (ii) with respect to
any RSU that is not a 409A Covered Award, immediately prior to the Change in Control, the Committee
may determine that such RSU will not be continued, assumed or have new rights substituted therefor
in accordance with Section 12.1(a) of the Plan, and 100% of any such RSUs that are unvested on the
date of such Change in Control shall become vested immediately prior to the Change in Control;
(iii) with respect to any RSU that is a 409A Covered Award, such Award shall either (x) be assumed
and continued in a manner that is intended to comply with Section 409A of the Code or (y) the
Committee may determine that such RSU will become 100% vested, paid and terminated in accordance
with Treasury Regulation Section 1.409A-3(j)(4)(ix)(A), (B) or (C) or as otherwise

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permitted under Section 409A of the Code; and (iv) in the event of a Participant’s Termination
by the Company without Cause that occurs upon or within twenty-four (24) months following a Change
in Control on or following the grant date and prior to the applicable vesting date 100% of any RSUs
that are unvested on the date of such Termination shall become immediately vested; provided,
however, that, if a Deferral Eligible Participant makes a deferral election with respect to a
Deferrable RSU pursuant to Section 4 (other than any such deferral elected prior to January 1 of
the calendar year in which the grant of the RSU was made to the Participant), the accelerated
vesting provided under this sub-section (iv) shall not apply to such Award if the Participant’s
Termination occurs on or before the Initial Vesting Date.

     3.5. Except as otherwise provided in Section 4 hereof, upon the vesting of each RSU, the
Participant shall receive one share of Common Stock, the ownership of which shall be recognized by
the Company through an uncertificated book entry credited to a book entry account maintained by the
Company (or its designee) on behalf of the Participant or such other method (including the issuance
of stock certificate) as determined by the Company in its sole discretion. Except as otherwise
provided in Section 4 hereof, actual payment of shares of stock underlying RSUs shall be paid
within thirty (30) days following vesting.

     3.6. Except as otherwise provided in Sections 3.3 and 3.4 hereof, RSUs that are not vested as
of the date of a Participant’s Termination for any reason shall terminate and be forfeited in their
entirety as of the date of such Termination. Notwithstanding anything herein to the contrary, in
the event of a Participant’s Termination for Cause, a Participant’s RSUs (whether vested or
unvested) shall terminate and be forfeited in their entirety as of the date of such Termination.

4. Deferral of Payment Date.

     4.1. Notwithstanding anything herein to the contrary, a Deferral Eligible Participant may
elect to defer, in accordance with this Section 4, the payment of shares of Common Stock following
vesting of an RSU that the Committee has determined, in its sole discretion, is eligible for
deferral as specifically provided in the applicable Award agreement (a “Deferrable RSU”).
To the extent an Eligible Employee is no longer considered a Top Hat Employee (and accordingly, is
no longer a Deferral Eligible Participant), the Committee may deem such Eligible Employee
ineligible to defer any additional RSUs and all then unvested RSUs shall continue to vest in
accordance with the applicable vesting schedule and all vested RSUs shall be payable in accordance
with the Eligible Employee’s then existing elections, subject to the terms of these Guidelines.

     4.2. Initial Deferral Elections. A Deferral Eligible Participant may, no later than 30 days
after the date on which an Award of a Deferrable RSU has been granted (the “Election
Period”), elect to defer each date on which a portion of the Award is scheduled to be paid,
provided that any such deferral election must provide for a payment date that occurs upon either:

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(a) the earlier of: (i) the date chosen by the Committee at any time in its sole
discretion within the calendar year in which the second, third, fourth, fifth, sixth or
seventh year anniversary following the vesting date of the Award occurs or such other time
period the Committee may establish at the time the Award is granted, as elected by the
Participant (a “Fixed Date”), (ii) the Deferral Eligible Participant’s “Separation
from Service” (within the meaning of Code Section 409A), subject to the six-month delay
applicable to “Specified Employees” within the meaning of Code Section 409A(a)(2)(B) as
set forth in Section 15.15(a) of the Plan (the “Six Month Delay”) and (iii) a
Change in Control; or

(b) the earlier of (i) the Deferral Eligible Participant’s Separation from Service,
subject to the Six Month Delay and (ii) a Change in Control.

With respect to payments made on a Fixed Date, the actual date of payment within the applicable
calendar year specified in Section 4.2(a)(i) hereof shall be determined within the sole discretion
of the Company. At the time the Deferral Eligible Participant makes an initial deferral election,
he or she must make an election to defer the payment of an Award either pursuant to Section 4.2(a)
or 4.2(b), and if the Deferral Eligible Participant elects the alternative under Section 4.2(a), he
or she must also make a Fixed Date election at such time on the election form prescribed by the
Company in accordance with Section 4.4 hereof.

     4.3. Subsequent Deferral Elections. A Deferral Eligible Participant shall be permitted to
extend the previously deferred payment dates applicable to Deferrable RSUs under an Award or make
an initial deferral election after the Election Period, provided that:

(a) the Deferral Eligible Participant makes such subsequent deferral election at least
(12) twelve months prior to the first scheduled payment date under such Award, which first
scheduled payment shall be January 1 of the first calendar year in which a deferred
payment would otherwise be made with regard to any Deferrable RSU previously deferred to a
Fixed Date in accordance with Section 4.2(a);

(b) a subsequent deferral election made by the Deferral Eligible Participant pursuant to
this Section 4.3 shall defer every previously deferred payment date applicable to
Deferrable RSUs under the Award by the same period of time (expressed in whole years) of
not less than five years (i.e., each previously deferred payment date shall be deferred by
the additional deferral period elected by the Deferral Eligible Participant, with the
result that, after the subsequent deferral election has been made, the payment dates will
continue to be staggered in time); and

(c) a Deferral Eligible Participant’s subsequent deferral election will not become
effective until (12) twelve months after the date on which it is made.

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     4.4. Any deferral pursuant to this Section 4 must be made in writing on an election form
prescribed by, and acceptable to, the Committee and in accordance with the procedures established
by the Committee. A deferral election is valid solely with respect to the Deferrable RSUs
identified on the election form and must comply with the requirements of Section 4 to be given
effect. A deferral election must apply to all RSUs under an Award for which such a deferral
election is made and may not apply solely with respect to a partial portion thereof.

     4.5. If a Deferral Eligible Participant makes an initial or subsequent deferral election with
respect to Deferrable RSUs, the payment of Common Stock under such Award, to the extent vested,
shall be made to the Deferral Eligible Participant on the applicable deferred payment date(s).

5. Dividend Equivalent Amounts. Dividends shall be credited to an RSU dividend book entry
account on behalf of each Participant with respect to each RSU held by such Participant, provided
that the right of each Participant to be entitled to and actually receive such dividend shall be
subject to the same restrictions as the RSU to which the dividend relates and shall be paid to the
Participant at the same time the Participant receives the payment of the shares of Common Stock
under the RSU (including upon any deferred payment date in accordance with Section 4). Unless
otherwise determined by the Committee, cash dividends shall not be reinvested in Common Stock and
shall remain uninvested and without interest.

6. Detrimental Activity. In the event a Participant engages in Detrimental Activity prior
to, or during the one year period after, any vesting of RSUs granted hereunder, the Committee may
direct (at any time within one year thereafter) that all unvested RSUs and all vested but unpaid
RSUs shall be immediately forfeited and that the Participant shall pay over to the Company an
amount equal to any gain the Participant realized from any RSUs or any Common Stock paid in
connection therewith which had vested in the period referred to above.

7. Amendment, Suspension or Termination. The Board or the Committee may at any time and
from time to time amend, suspend or terminate these Guidelines and any Award of RSUs, subject to
the terms of the Plan.

8. Section 16(b). To the extent required, these Guidelines are intended to comply with
Rule 16b-3 and the Committee shall interpret and administer these Guidelines in a manner consistent
therewith. If an officer (as defined in Rule 16b-3) is designated by the Committee to receive
RSUs, any such Award and the payment of Common Stock thereunder shall be deemed approved by the
Committee and shall be deemed an exempt purchase under Rule 16b-3. Any provisions inconsistent
with Rule 16b-3 shall be inoperative and shall not affect the validity of these Guidelines.

9. Withholding. The Participant shall be solely responsible for all applicable foreign,
federal, state, and local taxes with respect to the RSUs and the payment of Common Stock therunder;
provided, however, that at any time the Company is required to withhold any such taxes, the
Participant shall pay, or make arrangements to pay, in a

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manner satisfactory to the Company, an amount equal to the amount of all applicable federal, state
and local or foreign taxes that the Company is required to withhold at any time. In the absence of
such arrangements, the Company or one of its Affiliates shall have the right to withhold such taxes
from any amounts payable to the Participant, including, but not limited to, the right to withhold
Shares otherwise deliverable to the Participant under an Award of RSUs hereunder.

10. Plan Document. These Guidelines and an Award of RSUs are subject to the terms and
conditions of the Plan (including, without limitation, Sections 4.1(a) and 4.2 and Articles XI,
XII, XIII, XV and XVII). Specifically, the provisions of Section 15.15 of the Plan (“Section 409A
of the Code”) shall apply to any Award of RSUs under these Guidelines that is a 409A Covered Award.

11. ERISA Claims Procedures. With regard to a Deferrable RSU where a Deferral Eligible
Participant defers an RSU pursuant to Section 4 hereof, subject to the Six Month Delay, the
provisions of the U.S. Department of Labor Regulations Section 2560.503-1 governing claims
procedures shall apply to any disputes relating to such deferral awards.

6Exhibit 10.2

Exhibit 10.2

Form of RSU Agreement for

Employees other than
Messrs. McVey and Millet

RESTRICTED STOCK UNIT AGREEMENT

PURSUANT TO THE

MARKETAXESS HOLDINGS INC. 2004 STOCK INCENTIVE PLAN

(AMENDED AND RESTATED EFFECTIVE APRIL 28, 2006)

THIS RESTRICTED STOCK UNIT AGREEMENT (this “Agreement”), is made as of the [•] day of [•]
20[•] (the “Grant Date”) by and between MarketAxess Holdings Inc. (the “Company”)
and you (the “Participant”).

WHEREAS, the Board of Directors of the Company (the “Board”) adopted The MarketAxess
Holdings Inc. 2004 Stock Incentive Plan (Amended and Restated Effective April 28, 2006) (the
“Plan”) which is administered by a Committee appointed by the Company’s Board of Directors
(the “Committee”);

WHEREAS, pursuant to Section 3.3 of the Plan, the Committee has adopted guidelines (the
“Guidelines”) for the grant of restricted stock units (“RSUs”) under the Plan, which constitute an
Other Stock-Based Award under the Plan; and

WHEREAS, the Company, through the Committee, wishes to grant to the Participant RSUs as set forth
below.

NOW, THEREFORE, the Company and the Participant agree as follows:

	1.	 	Grant of RSUs. Subject to the terms and conditions of the Plan, the Guidelines and
this Agreement, on the Grant Date the Company awarded to the Participant [•] RSUs. [Insert
for Deferrable RSUs: The RSUs are Deferrable RSUs and the payment of shares of Common Stock
upon vesting in accordance with Section 2 may be deferred by the Participant in accordance
with Section 4 of the Guidelines. If the Participant chooses to defer the RSUs, the
Participant must complete an election form prescribed by the Committee regarding the election
period no later than 30 days after the Grant Date. If the Participant has Deferrable RSUs,
but does not make an election within 30 days after the Grant Date, the RSUs will not be
treated as Deferrable RSUs.] [Insert for Non-Deferrable RSUs: The RSUs hereunder are not
Deferrable RSUs and are not eligible for deferral under Section 4 of the Guidelines.]

	2.	 	Vesting. The RSUs shall become vested (but shall remain subject to Section 3 of this
Agreement) pursuant to [Insert for default vesting schedule: Sections 3.1 and 3.2 of the
Guidelines, subject to the accelerated vesting provisions under Sections 3.3 and 3,4 of the
Guidelines] [Insert for alternative vesting schedule: the following schedule, provided that
the Participant has not had a Termination from the date of grant until the applicable vesting
date:

	 	 	 
	Vesting Date	 	Incremental Percentage of RSUs Vested
	 
	 	 
	 
	 	 
	 
	 	 
	 
	 	 

	3.	 	Securities Representations. The grant of the RSUs and any issuance of shares of
Common Stock pursuant to this Agreement are being made by the Company in reliance upon the
following express representations and warranties of the Participant.

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	 	 	The Participant acknowledges, represents and warrants that:

3.1 he or she has been advised that he or she may be an “affiliate” within the meaning of Rule
144 under the Securities Act of 1933, as amended (the “Act”) and in this connection the
Company is relying in part on his or her representations set forth in this section;

3.2 if he or she is deemed an affiliate within the meaning of Rule 144 of the Act, the Common
Stock must be held indefinitely unless an exemption from any applicable resale restrictions is
available or the Company files an additional registration statement (or a “re-offer prospectus”)
with regard to such Common Stock and the Company is under no obligation to register the Common
Stock (or to file a “re-offer prospectus”);

3.3 if he or she is deemed an affiliate within the meaning of Rule 144 of the Act, he or she
understands that the exemption from registration under Rule 144 will not be available unless (i)
a public trading market then exists for the Common Stock, (ii) adequate information concerning
the Company is then available to the public, and (iii) other terms and conditions of Rule 144 or
any exemption therefrom are complied with; and that any sale of the Common Stock may be made
only in limited amounts in accordance with such terms and conditions.

	4.	 	Not an Employment Agreement. Neither the execution of this Agreement nor the
grant of RSUs hereunder constitute an agreement by the Company to employ or to continue to
employ the Participant during the entire, or any portion of, the term of this Agreement.

	5.	 	Miscellaneous.

	 	5.1	 	This Agreement shall inure to the benefit of and be binding upon the parties hereto and
their respective heirs, personal legal representatives, successors, trustees,
administrators, distributees, devisees and legatees. The Company may assign to, and
require, any successor (whether direct or indirect, by purchase, merger, consolidation or
otherwise) to all or substantially all of the business and/or assets of the Company or any
affiliate by which the Participant is employed to expressly assume and agree in writing to
perform this Agreement. Notwithstanding the foregoing, the Participant may not assign this
Agreement.

	 	5.2	 	This award of RSUs shall not affect in any way the right or power of the Board or
stockholders of the Company to make or authorize an adjustment, recapitalization or other
change in the capital structure or the business of the Company, any merger or consolidation
of the Company or subsidiaries, any issue of bonds, debentures, preferred or prior
preference stock ahead of or affecting the Common Stock, the dissolution or liquidation of
the Company, any sale or transfer of all or part of its assets or business or any other
corporate act or proceeding.

	 	5.3	 	The Participant agrees that the award of the RSUs hereunder is special incentive
compensation and that it, any dividends paid thereon (even if treated as compensation for
tax purposes) will not be taken into account as “salary” or “compensation” or “bonus” in
determining the amount of any payment under any pension, retirement or profit-sharing plan
of the Company or any life insurance, disability or other benefit plan of the Company.

	 	5.4	 	No modification or waiver of any of the provisions of this Agreement shall be effective
unless in writing and signed by the party against whom it is sought to be enforced.

	 	5.5	 	This Agreement may be executed in one or more counterparts, all of which taken together
shall constitute one contract.

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	 	5.6	 	The failure of any party hereto at any time to require performance by another party of
any provision of this Agreement shall not affect the right of such party to require
performance of that provision, and any waiver by any party of any breach of any provision
of this Agreement shall not be construed as a waiver of any continuing or succeeding breach
of such provision, a waiver of the provision itself, or a waiver of any right under this
Agreement.

	 	5.7	 	The headings of the sections of this Agreement have been inserted for convenience of
reference only and shall in no way restrict or modify any of the terms or provisions
hereof.

	 	5.8	 	All notices, consents, requests, approvals, instructions and other communications
provided for herein shall be in writing and validly given or made when delivered, or on the
second succeeding business day after being mailed by registered or certified mail,
whichever is earlier, to the persons entitled or required to receive the same, at the
addresses set forth at the heading of this Agreement or to such other address as either
party may designate by like notice. Notices to the Company shall be addressed to the
Compensation Committee of the Board with a copy to General Counsel, MarketAxess Holdings
Inc., 299 Park Avenue, 10th Floor, New York, New York, 10171.

	 	5.9	 	This Agreement shall be construed, interpreted and governed and the legal relationships
of the parties determined in accordance with the internal laws of the State of Delaware
without reference to rules relating to conflicts of law.

	6.	 	Provisions of Plan and Guidelines Control. This Agreement is subject to all the
terms, conditions and provisions of the Plan and the Guidelines, including, without
limitation, the amendment provisions thereof, and to such rules, regulations and
interpretations relating to the Plan and the Guidelines as may be adopted by the Committee
and as may be in effect from time to time. The Plan and the Guidelines are incorporated
herein by reference. A copy of the Plan and the Guidelines have been delivered to the
Participant. If and to the extent that this Agreement conflicts or is inconsistent with
the terms, conditions and provisions of the Plan and the Guidelines, the Plan and the
Guidelines shall control, and this Agreement shall be deemed to be modified accordingly.
Unless otherwise indicated, any capitalized term used but not defined herein shall have the
meaning ascribed to such term in the Plan or the Guidelines. This Agreement contains the
entire understanding of the parties with respect to the subject matter hereof (other than
any other documents expressly contemplated herein or in the Plan or the Guidelines) and
supersedes any prior agreements between the Company and the Participant.

IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed as of
the day and year first above written.

	 	 	 	 	 
	 	MARKETAXESS HOLDINGS INC.

 	 
	 	By:  	 	 
	 	 	Name:  	 	 
	 	 	Title:  	 	 
	 

PARTICIPANT

	 	 	 

	 
	 	 
	 
	 	 
	Name:

	 	 

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