Document:

EX-10.8

 Exhibit 10.8 

ARMO BIOSCIENCES 
 October 26, 2017 

Herb Cross 
 [Address] 

Re: Employment Offer; Employment Agreement 
 Dear Herb:

 ARMO BioSciences, Inc. (the “Company”) is pleased to offer you employment on the following terms: 

1.    Position. Your initial title will be Chief Financial Officer, and you will report to the Company’s Chief
Executive Officer. This is a full-time position. You will be responsible for the establishment of a highly competitive team and supervise all activities related to finance and other related activities including, but not limited to IT and facilities,
at the Company. As the company grows, your responsibilities may change. While you render services to the Company, you will not engage in any other employment, consulting or other business activity (whether full-time or part-time) that would create a
conflict of interest with the Company. By signing this letter agreement, you confirm to the Company that you have no contractual commitments or other legal obligations that would prohibit you from performing your duties for the Company. 

2.    Cash Compensation. You will earn a monthly salary in the gross amount of $25,833.33 which is
equivalent to $310,000 on an annualized basis. Your salary will be payable pursuant to the Company’s regular payroll schedule (or in the same manner as other officers of the Company), and will be subject to tax and other required withholdings.

 You will be eligible to earn an annual bonus up to 35% of the amount of base salary actually paid to you during that calendar year. The
precise amount of such bonus will be determined by the Board, based on the extent to which the Company meets minimum and exceeds minimum performance-related goals proposed by management and approved by the Board for the Company’s fiscal year
ending December 31. The determinations of the Company’s Board of Directors with respect to your bonus will be final and binding. 
 Any
bonus for a fiscal year will be paid within 21/2 months after the close of that fiscal year, but only if you are still employed by the
Company at the time of payment. 
 3.    Employee Benefits. As a regular employee of the Company, you will
be eligible to participate in a number of Company-sponsored benefits. In addition, you will be entitled to paid vacation in accordance with the Company’s vacation policy, as in effect from time to time.

 Herb Cross 

October 26, 2017 
  Page
 2
 
  

 4.    Stock Options. Subject to the approval of the
Company’s Board of Directors or its Compensation Committee, you will be granted an option to purchase 1,133,331 shares of the Company’s Common Stock (the “Option”). The exercise price per share of the Option will be the fair
market value of the Company’s common stock as determined by the Board of Directors or the Compensation Committee when the Option is granted. The Option will be subject to the terms and conditions applicable to options granted under the
Company’s Stock Plan (the “Plan”), as described in the Plan and the applicable Stock Option Agreement. You will vest 25% of the Option shares after 12 months of continuous service, and the balance will vest in equal monthly
installments over the next 36 months of continuous service, as described in the applicable Stock Option Agreement. The Option will be immediately exercisable, but in the event that your service terminates for any reason before you vest in the
shares, the unvested portion of the purchased shares will be subject to repurchase by the Company pursuant to the terms of the Plan. 

5.    Severance Benefits. 

(a)    General. If you are subject to a Termination Without Cause, then you will be entitled to the benefits
described in this Section 5. However, this Section 5 will not apply unless you (i) have returned all Company property in your possession and (ii) have executed a general release of all claims that you may have against the Company
or persons affiliated with the Company. The release must be in the form prescribed by the Company, without alterations. You must execute and return the release on or before the date specified by the Company in the prescribed form (the “Release
Deadline”). The Release Deadline will in no event be later than 50 days after your Separation. If you fail to return the release on or before the Release Deadline, or if you revoke the release, then you will not be entitled to the benefits
described in this Section 5. 
 (b)    Salary Continuation. If you are subject to a Termination
Without Cause, then the Company will continue to pay your base salary for a period of six months after your Separation. Your base salary will be paid at the rate in effect at the time of your Separation and in accordance with the Company’s
standard payroll procedures. The salary continuation payments will commence within 60 days after your Separation and, once they commence, will include any unpaid amounts accrued from the date of your Separation. However, if the 60-day period described in the preceding sentence spans two calendar years, then the payments will in any event begin in the second calendar year. 

(c)    COBRA. If you are subject to a Termination Without Cause and you elect to continue your health insurance
coverage under the Consolidated Omnibus Budget Reconciliation Act (“COBRA”) following your Separation, then the Company will pay the same portion of your monthly premium under COBRA as it pays for active employees and their eligible
dependents until the earliest of (i) the close of the six-month period following your Separation, (ii) the expiration of your continuation coverage under COBRA or (iii) the date when you become
eligible for substantially equivalent health insurance coverage in connection with new employment. Notwithstanding the foregoing if the Company determines in its sole discretion that it cannot provide the preceding benefit without potentially
violating, or being subject to an excise tax under, applicable law (including, without limitation, Section 2716 of the 

 Herb Cross 

October 26, 2017 
  Page
 3
 
  

 
Public Health Service Act), the Company will in lieu thereof provide to you a taxable monthly payment in an amount equal to the monthly COBRA premium that you would be required to pay to continue
your group health coverage in effect on the termination of employment date (which amount will be based on the premium for the first month of COBRA coverage), which payments will be made regardless of whether you elect COBRA continuation coverage and
will commence on the month following your Separation and will end on the earlier of (x) the date upon which you obtain other employment or (y) the date the Company has paid an amount equal to six (6) months. For the avoidance of
doubt, the taxable payments in lieu of COBRA reimbursements may be used for any purpose, including, but not limited to continuation coverage under COBRA, and will be subject to all applicable tax withholding. 

(d)    Accelerated Vesting. If you are subject to a Termination Without Cause prior to a Change in Control,
then the vested percentage of the shares subject to the Option will be determined by adding six months to the actual period of service that you have completed with the Company. Further, you will vest in 100% of your remaining unvested Option shares
if (a) the Company is subject to a Change in Control before your continuous service with the Company terminates and (b) you are subject to an Involuntary Termination within 12 months after that Change in Control. 

6.    Proprietary Information and Inventions Agreement. Like all Company employees, you
will be required, as a condition of your employment with the Company, to sign the Company’s standard Proprietary Information and Inventions Agreement, a copy of which is attached hereto as Exhibit A. 

7.    Employment Relationship. Employment with the Company is for no specific period of time. Your
employment with the Company will be “at will,” meaning that either you or the Company may terminate your employment at any time and for any reason, with or without cause. Any contrary representations that may have been made to you are
superseded by this letter agreement. This is the full and complete agreement between you and the Company on this term. Although your job duties, title, compensation and benefits, as well as the Company’s personnel policies and procedures, may
change from time to time, the “at will” nature of your employment may only be changed in an express written agreement signed by you and a duly authorized officer of the Company (other than you). 

8.    Tax Matters. 

(a)    Withholding. All forms of compensation referred to in this letter agreement are subject to reduction to
reflect applicable withholding and payroll taxes and other deductions required by law. 
 (b)    Tax
Advice. You are encouraged to obtain your own tax advice regarding your compensation from the Company. You agree that the Company does not have a duty to design its compensation policies in a manner that minimizes your tax liabilities, and
you will not make any claim against the Company or its Board of Directors related to tax liabilities arising from your compensation. 

 Herb Cross 

October 26, 2017 
  Page
 4
 
  

 9.    Interpretation, Amendment and
Enforcement. This letter agreement and Exhibit A supersede and replace any prior agreements, representations or understandings (whether written, oral, implied or otherwise) between you and the Company and constitute the complete agreement
between you and the Company regarding the subject matter set forth herein. This letter agreement may not be amended or modified, except by an express written agreement signed by both you and a duly authorized officer of the Company. The terms of
this letter agreement and the resolution of any disputes as to the meaning, effect, performance or validity of this letter agreement or arising out of, related to, or in any way connected with, this letter agreement, your employment with the Company
or any other relationship between you and the Company (the “Disputes”) will be governed by California law, excluding laws relating to conflicts or choice of law. You and the Company submit to the exclusive personal jurisdiction of the
federal and state courts located in California in connection with any Dispute or any claim related to any Dispute. 

10.    Definitions. The following terms have the meaning set forth below wherever they are used in this letter
agreement: 
 “Cause” means your (i) unauthorized use or disclosure of the Company’s confidential information or
trade secrets, which use or disclosure causes material harm to the Company; (ii) material breach of any agreement with the Company; (iii) material failure to comply with the Company’s written policies or rules; (iv) conviction
of, or plea of “guilty” or “no contest” to, a felony under the laws of the United States or any state thereof; (v) gross negligence or willful misconduct; (vi) continuing failure to perform assigned duties after
receiving written notification of such failure from the Board of Directors; or (vii) failure to cooperate in good faith with a governmental or internal investigation of the Company or its directors, officers or employees, if the Company has
requested your cooperation. 
 “Change in Control” means (i) the consummation of a sale, merger or
consolidation of the Company with or into another entity or (ii) the dissolution, liquidation or winding up of the Company. The foregoing notwithstanding, a sale, merger or consolidation of the Company shall not constitute a “Corporate
Transaction” if immediately after such sale, merger or consolidation a majority of the voting power of the capital stock of the continuing or surviving entity, or any direct or indirect parent corporation of such continuing or surviving entity,
will be owned by the persons who were the Company’s stockholders immediately prior to such sale, merger or consolidation in substantially the same proportions as their ownership of the voting power of the Company’s capital stock
immediately prior to such merger or consolidation.. 
 “Involuntary Termination” means either (a) your
Termination Without Cause or (b) your Resignation for Good Reason. 
 “Resignation for Good
Reason” means that you resign within 12 months after one of the following conditions has come into existence without your consent: (i) a reduction in your base salary by more than 10%; (ii) a material diminution of your authority,
duties or responsibilities; or (iii) a relocation of your principal workplace by more than 30 miles. A condition shall not be considered “Good Reason” unless you give the Company written notice of such condition within 90 days after
such condition comes into existence and the Company fails to remedy such condition within 30 days after receiving your written notice. 

 Herb Cross 

October 26, 2017 
  Page
 5
 
  

 “Separation” means a “separation from service,” as defined in the
regulations under Section 409A of the Code. 
 “Termination Without Cause” means a Separation as a
result of a termination of your employment by the Company without Cause, provided you are willing and able to continue performing services within the meaning of Treasury Regulation 1.409A-1(n)(1). 

* * * * * 
 We hope that you will
accept our offer to join the Company. You may indicate your agreement with these terms and accept this offer by signing and dating both the enclosed duplicate original of this letter agreement and the enclosed Proprietary Information and Inventions
Agreement and returning them to me. As required by law, your employment with the Company is contingent upon your providing legal proof of your identity and authorization to work in the United States. 

The start date of your employment at the Company is November 27, 2017. Please discuss with the CEO in case this date is not feasible.

  

	
	Very truly yours,
	
	ARMO BIOSCIENCES INC.
	
	 /s/ Peter Van Vlasselaer

	Peter Van Vlasselaer, President and CEO

  

			
	I have read and accept this employment offer:
	
	
                    /s/
Herb Cross

	                    Signature of Herb Cross
		
	Dated:	 	 11/2/17

 Attachment 
 Exhibit A:
Proprietary Information and Inventions Agreement 

 PROPRIETARY INFORMATION AND INVENTIONS AGREEMENT 

The following confirms and memorializes an agreement that ARMO Biosciences, Inc., a Delaware corporation (the “Company”) and I (Herb
Cross) have had since the commencement of my employment (which term, for purposes of this agreement, shall be deemed to include any relationship of service to the Company that I may have had prior to actually becoming an employee) with the Company
in any capacity and that is and has been a material part of the consideration for my employment by Company: 
 1.    I
have not entered into, and I agree I will not enter into, any agreement either written or oral in conflict with this Agreement or my employment with Company. I will not violate any agreement with or rights of any third party or, except as expressly
authorized by Company in writing hereafter, use or disclose my own or any third party’s confidential information or intellectual property when acting within the scope of my employment or otherwise on behalf of Company. Further, I have not
retained anything containing any confidential information of a prior employer or other third party, whether or not created by me. 

2.    Company shall own all right, title and interest (including patent rights, copyrights, trade secret rights, mask work
rights, sui generis database rights and all other intellectual property rights of any sort throughout the world) relating to any and all inventions (whether or not patentable), works of authorship, mask works, designs, know-how, ideas and information made or conceived or reduced to practice, in whole or in part, by me during the term of my employment with Company to and only to the fullest extent allowed by California Labor Code
Section 2870 (which is attached as Appendix A) (collectively “Inventions”) and I will promptly disclose all Inventions to Company. Without disclosing any third party confidential information, I will also disclose anything I believe is
excluded by Section 2870 so that the Company can make an independent assessment. I hereby make all assignments necessary to accomplish the foregoing. I shall further assist Company, at Company’s expense, to further evidence, record and
perfect such assignments, and to perfect, obtain, maintain, enforce, and defend any rights specified to be so owned or assigned. I hereby irrevocably designate and appoint Company as my agent and attorney-in-fact, coupled with an interest and with full power of substitution, to act for and in my behalf to execute and file any document and to do all other lawfully permitted acts to further the purposes
of the foregoing with the same legal force and effect as if executed by me. Without limiting Section 1 or Company’s other rights and remedies, if, when acting within the scope of my employment or otherwise on behalf of Company, I use or
disclose my own or any third party’s confidential information or intellectual property (or if any Invention cannot be fully made, used, reproduced, distributed and otherwise exploited without using or violating the foregoing), Company will have
and I hereby grant Company a perpetual, irrevocable, worldwide royalty-free, non-exclusive, sublicensable right and license to exploit and exercise all such confidential information and intellectual property
rights. 
 3.    To the extent allowed by law, paragraph 2 includes all rights of paternity, integrity, disclosure and
withdrawal and any other rights that may be known as or referred to as “moral rights,” “artist’s rights,” “droit moral,” or the like (collectively “Moral Rights”). To the extent I retain any such Moral
Rights under applicable law, I hereby ratify and consent to any action that may be taken with respect to such Moral Rights by or authorized by Company and agree not to assert any Moral Rights with respect thereto. I will confirm any such
ratifications, consents and agreements from time to time as requested by Company. 

  
 1 

 4.    I agree that all Inventions and all other business, technical and
financial information (including, without limitation, the identity of and information relating to customers or employees) I develop, learn or obtain during the term of my employment that relate to Company or the business or demonstrably anticipated
business of Company or that are received by or for Company in confidence, constitute “Proprietary Information.” I will hold in confidence and not disclose or, except within the scope of my employment, use any Proprietary Information.
However, I shall not be obligated under this paragraph with respect to information I can document is or becomes readily publicly available without restriction through no fault of mine. Upon termination of my employment, I will promptly return to
Company all items containing or embodying Proprietary Information (including all copies), except that I may keep my personal copies of (i) my compensation records, (ii) materials distributed to shareholders generally and (iii) this
Agreement. I also recognize and agree that I have no expectation of privacy with respect to Company’s telecommunications, networking or information processing systems (including, without limitation, stored computer files, email messages and
voice messages) and that my activity and any files or messages on or using any of those systems may be monitored at any time without notice. 

5.    Until one year after the term of my employment, I will not encourage or solicit any employee or consultant of
Company to leave Company for any reason (except for the bona fide firing of Company personnel within the scope of my employment). 

6.    I agree that during the term of my employment with Company (whether or not during business hours), I will not engage
in any activity that is in any way competitive with the business or demonstrably anticipated business of Company, and I will not assist any other person or organization in competing or in preparing to compete with any business or demonstrably
anticipated business of Company. 
 7.    I agree that this Agreement is not an employment contract for any particular
term and that I have the right to resign and Company has the right to terminate my employment at will, at any time, for any or no reason, with or without cause. In addition, this Agreement does not purport to set forth all of the terms and
conditions of my employment, and, as an employee of Company, I have obligations to Company which are not set forth in this Agreement. However, the terms of this Agreement govern over any inconsistent terms and can only be changed by a subsequent
written agreement signed by the President of Company. 
 8.    I agree that my obligations under paragraphs 2, 3, 4 and
5 of this Agreement shall continue in effect after termination of my employment, regardless of the reason or reasons for termination, and whether such termination is voluntary or involuntary on my part, and that Company is entitled to communicate my
obligations under this Agreement to any future employer or potential employer of mine. My obligations under paragraphs 2, 3 and 4 also shall be binding upon my heirs, executors, assigns, and administrators and shall inure to the benefit of Company,
its subsidiaries, successors and assigns. 

  
 2 

 9.    Any dispute in the meaning, effect or validity of this Agreement shall
be resolved in accordance with the laws of the State of California without regard to the conflict of laws provisions thereof. I further agree that if one or more provisions of this Agreement are held to be illegal or unenforceable under applicable
California law, such illegal or unenforceable portion(s) shall be limited or excluded from this Agreement to the minimum extent required so that this Agreement shall otherwise remain in full force and effect and enforceable in accordance with its
terms. This Agreement is fully assignable and transferable by Company, but any purported assignment or transfer by me is void. I also understand that any breach of this Agreement will cause irreparable harm to Company for which damages would not be
an adequate remedy, and, therefore, Company will be entitled to injunctive relief with respect thereto in addition to any other remedies and without any requirement to post bond. 

NOTICE: This agreement does not affect any immunity under 18 USC Sections 1833(b) (1) or (2), which read as follows (note that for purposes of this
statute only, individuals performing work as contractors or consultants are considered to be employees): 
 (1)    An
individual shall not be held criminally or civilly liable under any Federal or State trade secret law for the disclosure of a trade secret that (A) is made (i) in confidence to a Federal, State, or local government official, either
directly or indirectly, or to an attorney; and (ii) solely for the purpose of reporting or investigating a suspected violation of law; or (B) is made in a complaint or other document filed in a lawsuit or other proceeding, if such filing
is made under seal. 
 (2)    An individual who files a lawsuit for retaliation by an employer for reporting a suspected
violation of law may disclose the trade secret to the attorney of the individual and use the trade secret information in the court proceeding, if the individual (A) files any document containing the trade secret under seal; and (B) does
not disclose the trade secret, except pursuant to court order. 
 I HAVE READ THIS AGREEMENT CAREFULLY AND I UNDERSTAND AND ACCEPT THE
OBLIGATIONS WHICH IT IMPOSES UPON ME WITHOUT RESERVATION. NO PROMISES OR REPRESENTATIONS HAVE BEEN MADE TO ME TO INDUCE ME TO SIGN THIS AGREEMENT. I SIGN THIS AGREEMENT VOLUNTARILY AND FREELY, IN DUPLICATE, WITH THE UNDERSTANDING THAT THE COMPANY
WILL RETAIN ONE COUNTERPART AND THE OTHER COUNTERPART WILL BE RETAINED BY ME. 
  

							
	November 2, 2017	 		 		 	Employee
				
		 		 		 	           /s/ Herb Cross

		 		 		 	Signature
				
		 		 		 	 Herb Cross

		 		 		 	Name (Printed)

  
 3 

			
	Accepted and Agreed to:
		
	By:	 	     /s/ Peter Van Vlasselaer

	Name:	 	Peter Van Vlasselaer, PhD
	Title:	 	President and CEO

  
 4 

 APPENDIX A 

California Labor Code Section 2870. Application of provision providing that employee
shall assign or offer to assign rights in invention to employer. 

(a)    Any provision in an employment agreement which provides that an employee shall assign, or offer to assign, any of
his or her rights in an invention to his or her employer shall not apply to an invention that the employee developed entirely on his or her own time without using the employer’s equipment, supplies, facilities, or trade secret information
except for those inventions that either: 
 (1)    Relate at the time of conception or reduction to practice of the
invention to the employer’s business, or actual or demonstrably anticipated research or development of the employer; or 

(2)    Result from any work performed by the employee for his employer. 

(b)    To the extent a provision in an employment agreement purports to require an employee to assign an invention
otherwise excluded from being required to be assigned under subdivision (a), the provision is against the public policy of this state and is unenforceable.EX-10.9

 Exhibit 10.9 

LEASE 
 BETWEEN 

METROPOLITAN LIFE INSURANCE COMPANY (LANDLORD) 

AND 
 ARMO BIOSCIENCES, INC.
(TENANT) 
 SEAPORT CENTER 

Redwood City, California 

 TABLE OF CONTENTS 
  

							
	 	  	PAGE	 
	 ARTICLE ONE BASIC LEASE PROVISIONS
	  	 	1	 
	 1.01
	 	 BASIC LEASE PROVISIONS
	  	 	1	 
	 1.02
	 	 ENUMERATION OF EXHIBITS & RIDER(S)
	  	 	2	 
	 1.03
	 	 DEFINITIONS
	  	 	3	 
		
	 ARTICLE TWO PREMISES, TERM, FAILURE TO GIVE POSSESSION, COMMON AREAS AND
PARKING
	  	 	7	 
	 2.01
	 	 LEASE OF PREMISES
	  	 	7	 
	 2.02
	 	 AREA OF PREMISES
	  	 	7	 
	 2.03
	 	 CONDITION OF PREMISES (See Rider
	  	 	7	 
	 2.04
	 	 COMMON AREAS & PARKING
	  	 	7	 
		
	 ARTICLE THREE RENT
	  	 	8	 
		
	 ARTICLE FOUR OPERATING EXPENSES, RENT ADJUSTMENTS AND PAYMENTS 
	  	 	8	 
	 4.01
	 	 TENANT’S SHARE OF OPERATING EXPENSES
	  	 	8	 
	 4.02
	 	 RENT ADJUSTMENTS
	  	 	9	 
	 4.03
	 	 STATEMENT OF LANDLORD
	  	 	9	 
	 4.04
	 	 BOOKS AND RECORDS
	  	 	10	 
	 4.05
	 	 TENANT OR LEASE SPECIFIC TAXES
	  	 	10	 
		
	 ARTICLE FIVE SECURITY
	  	 	10	 
		
	 ARTICLE SIX UTILITIES & SERVICES
	  	 	11	 
	 6.01
	 	 LANDLORD’S GENERAL SERVICES
	  	 	11	 
	 6.02
	 	 TENANT TO OBTAIN & PAY DIRECTLY
	  	 	11	 
	 6.03
	 	 TELEPHONE SERVICES
	  	 	11	 
	 6.04
	 	 FAILURE OR INTERRUPTION OF UTILITY OR SERVICE
	  	 	12	 
	 6.05
	 	 CHOICE OF SERVICE PROVIDER
	  	 	12	 
	 6.06
	 	 SIGNAGE
	  	 	12	 
		
	 ARTICLE SEVEN POSSESSION, USE AND CONDITION OF PREMISES
	  	 	13	 
	 7.01
	 	 POSSESSION AND USE OF PREMISES
	  	 	13	 
	 7.02
	 	 HAZARDOUS MATERIAL
	  	 	13	 
	 7.03
	 	 LANDLORD ACCESS TO PREMISES; APPROVALS
	  	 	15	 
	 7.04
	 	 QUIET ENJOYMENT
	  	 	16	 
		
	 ARTICLE EIGHT MAINTENANCE
	  	 	16	 
	 8.01
	 	 LANDLORD’S MAINTENANCE
	  	 	16	 
	 8.02
	 	 TENANT’S MAINTENANCE
	  	 	16	 
		
	 ARTICLE NINE ALTERATIONS AND IMPROVEMENTS
	  	 	17	 
	 9.01
	 	 TENANT ALTERATIONS
	  	 	17	 
	 9.02
	 	 LIENS
	  	 	18	 
		
	 ARTICLE TEN ASSIGNMENT AND SUBLETTING
	  	 	18	 
	 10.01
	 	 ASSIGNMENT AND SUBLETTING
	  	 	18	 
	 10.02
	 	 RECAPTURE
	  	 	20	 
	 10.03
	 	 EXCESS RENT
	  	 	20	 
	 10.04
	 	 TENANT LIABILITY
	  	 	20	 
	 10.05
	 	 ASSUMPTION AND ATTORNMENT
	  	 	21	 
		
	 ARTICLE ELEVEN DEFAULT AND REMEDIES
	  	 	21	 
	 11.01
	 	 EVENTS OF DEFAULT
	  	 	21	 
	 11.02
	 	 LANDLORD’S REMEDIES
	  	 	22	 
	 11.03
	 	 ATTORNEY’S FEES
	  	 	23	 
	 11.04
	 	 BANKRUPTCY
	  	 	24	 
	 11.05
	 	 LANDLORD’S DEFAULT
	  	 	24	 

  
 i 

							
	 ARTICLE TWELVE SURRENDER OF PREMISES
	  	 	24	 
	 12.01
	 	 IN GENERAL
	  	 	24	 
	 12.02
	 	 LANDLORD’S RIGHTS
	  	 	25	 
		
	 ARTICLE THIRTEEN HOLDING OVER
	  	 	25	 
		
	 ARTICLE FOURTEEN DAMAGE BY FIRE OR OTHER CASUALTY
	  	 	25	 
	 14.01
	 	 SUBSTANTIAL UNTENANTABILITY
	  	 	25	 
	 14.02
	 	 INSUBSTANTIAL UNTENANTABILITY
	  	 	26	 
	 14.03
	 	 RENT ABATEMENT
	  	 	26	 
	 14.04
	 	 WAIVER OF STATUTORY REMEDIES
	  	 	27	 
		
	 ARTICLE FIFTEEN EMINENT DOMAIN
	  	 	27	 
	 15.01
	 	 TAKING OF WHOLE OR SUBSTANTIAL PART
	  	 	27	 
	 15.02
	 	 TAKING OF PART
	  	 	27	 
	 15.03
	 	 COMPENSATION
	  	 	27	 
		
	 ARTICLE SIXTEEN INSURANCE
	  	 	28	 
	 16.01
	 	 TENANT’S INSURANCE
	  	 	28	 
	 16.02
	 	 FORM OF POLICIES
	  	 	28	 
	 16.03
	 	 LANDLORD’S INSURANCE
	  	 	28	 
	 16.04
	 	 WAIVER OF SUBROGATION
	  	 	28	 
	 16.05
	 	 NOTICE OF CASUALTY
	  	 	29	 
		
	 ARTICLE SEVENTEEN WAIVER OF CLAIMS AND INDEMNITY
	  	 	29	 
	 17.01
	 	 WAIVER OF CLAIMS
	  	 	29	 
	 17.02
	 	 INDEMNITY BY TENANT
	  	 	30	 
	 17.03
	 	 WAIVER OF CONSEQUENTIAL DAMAGES
	  	 	30	 
		
	 ARTICLE EIGHTEEN RULES AND REGULATIONS
	  	 	30	 
	 18.01
	 	 RULES
	  	 	30	 
	 18.02
	 	 ENFORCEMENT
	  	 	30	 
		
	 ARTICLE NINETEEN LANDLORD’S RESERVED RIGHTS
	  	 	30	 
		
	 ARTICLE TWENTY ESTOPPEL CERTIFICATE
	  	 	31	 
	 20.01
	 	 IN GENERAL
	  	 	31	 
	 20.02
	 	 ENFORCEMENT
	  	 	31	 
		
	 ARTICLE TWENTY-ONE INTENTIONALLY
OMITTED
	  	 	31	 
		
	 ARTICLE TWENTY-TWO REAL ESTATE
BROKERS
	  	 	31	 
		
	 ARTICLE TWENTY-THREE MORTGAGEE PROTECTION
	  	 	32	 
	 23.01
	 	 SUBORDINATION AND ATTORNMENT
	  	 	32	 
	 23.02
	 	 MORTGAGEE PROTECTION
	  	 	32	 
		
	 ARTICLE TWENTY-FOUR NOTICES
	  	 	32	 
		
	 ARTICLE TWENTY-FIVE EXERCISE FACILITY
	  	 	33	 
		
	 ARTICLE TWENTY-SIX OFAC
	  	 	33	 
		
	 ARTICLE TWENTY-SEVEN MISCELLANEOUS
	  	 	34	 
	 27.01
	 	 LATE CHARGES
	  	 	34	 
	 27.02
	 	 NO JURY TRIAL; VENUE: JURISDICTION
	  	 	34	 
	 27.03
	 	 DEFAULT UNDER OTHER LEASE
	  	 	34	 
	 27.04
	 	 OPTION
	  	 	34	 
	 27.05
	 	 TENANT AUTHORITY
	  	 	35	 
	 27.06
	 	 ENTIRE AGREEMENT
	  	 	35	 

  
 ii 

							
	 27.07
	 	 MODIFICATION OF LEASE FOR BENEFIT OF MORTGAGEE
	  	 	35	 
	 27.08
	 	 EXCULPATION
	  	 	35	 
	 27.09
	 	 ACCORD AND SATISFACTION
	  	 	35	 
	 27.10
	 	 LANDLORD’S OBLIGATIONS ON SALE OF BUILDING
	  	 	35	 
	 27.11
	 	 BINDING EFFECT
	  	 	35	 
	 27.12
	 	 CAPTIONS
	  	 	35	 
	 27.13
	 	 TIME: APPLICABLE LAW: CONSTRUCTION
	  	 	36	 
	 27.14
	 	 ABANDONMENT
	  	 	36	 
	 27.15
	 	 LANDLORD’S RIGHT TO PERFORM TENANT’S DUTIES
	  	 	36	 
	 27.16
	 	 SECURITY SYSTEM
	  	 	36	 
	 27.17
	 	 NO LIGHT, AIR OR VIEW EASEMENTS
	  	 	36	 
	 27.18
	 	 RECORDATION
	  	 	36	 
	 27.19
	 	 SURVIVAL
	  	 	36	 
	 27.20
	 	 EXHIBITS OR RIDERS
	  	 	36	 

  
 iii 

 LEASE 

ARTICLE ONE 
 BASIC LEASE PROVISIONS

 1.01    BASIC LEASE PROVISIONS 
 In the
event of any conflict between these Basic Lease Provisions and any other Lease provision, such other Lease provision shall control. 
  

	(1)	BUILDING AND ADDRESS: Building Number 3, located in Phase I (“Tenant’s Phase”) of Seaport Centre. as of the Lease Date, the Building includes the address 575 Chesapeake Drive in Redwood City, California,
94063. 

 (2)    LANDLORD AND ADDRESS: 

Metropolitan Life Insurance Company, 

A New York corporation 
 Notices
to Landlord shall be addressed: 
 Metropolitan Life Insurance Company 

c/0 Seaport Centre Manager 
 701
Chesapeake Drive 
 Redwood City, CA 94063 

With copies to the following: 

Metropolitan Life Insurance Company 

425 Market Street, Suite 1050 

San Francisco, CA 94105 

Attention: Director, EIM 
 and

 Metropolitan Life Insurance Company 

425 Market Street, Suite 1050 

San Francisco, CA 94105 

Attention: Associate General Counsel 
  

	(3)	TENANT AND CURRENT ADDRESS: 

  

					
	(a)	 	Name:	  	ARMO Biosciences, Inc.
	(b)	 	State of [formation and type of entity]:	  	Delaware corporation
	(c)	 	Federal Tax Identification Number:	  	                                  

 Tenant shall promptly notify Landlord of any change in the foregoing items. 

 

			
	Notices to Tenant shall be addressed:	  	
		
	Prior to Commencement Date:	  	On & After Commencement Date
		
	3445 Woodside Road	  	To Tenant at the Premises
	Woodside, California 94062	  	
	Attention: Peter Van Vlasselaer	  	

  

	(4)	DATE OF LEASE: as of February 19, 2013 

	(5)	LEASE TERM: Forty-Eight (48) months 

  

	(6)	PROJECTED COMMENCEMENT DATE: April 1, 2013 

  

	(7)	PROJECTED EXPIRATION DATE: Forty-Eight (48) months after the Commencement Date 

  

	(8)	MONTHLY BASE RENT (initial monthly installment due upon Tenant’s execution): 

  

					
	 Period from/to
	  	Monthly	 
	 Month 1 — Month 12
	  	$	11,700.68	 
	 Month 13 — Month 24
	  	$	22,610.00	 
	 Month 25 — Month 36
	  	$	23,288.30	 
	 Month 37 — Month 48
	  	$	23,986.95	 

  

	(9)	RENT ADJUSTMENT DEPOSIT (initial monthly rate, until further notice):$5,539.45 (initial monthly installment due upon Tenant’s execution) 

 

					
			
	(10)	 	RENTABLE AREA OF THE PREMISES:	 	11,305 square feet
			
	(11)	 	RENTABLE AREA OF THE BUILDING:	 	37,856 square feet
			
	(12)	 	RENTABLE AREA OF THE PHASE:	 	301,824 Square feet
			
	(13)	 	RENTABLE AREA OF THE PROJECT:	 	537,444 square feet

  

	(14)	SECURITY: The cash amount of Seventy-One Thousand Nine Hundred Sixty and 85/100 Dollars ($71,960.85) as provided in Article Five. 

 

	(15)	SUITE NUMBER 84/OR ADDRESS OF PREMISES: 575 Chesapeake Drive 

  

	(16)	TENANT’S SHARE: 

  

					
	 Tenant’s Building Share:
	  	 	29.86	% 
	 Tenant’s Phase Share:
	  	 	3.75	% 
	 Tenant’s Project Share:
	  	 	2.10	% 

  

	(17)	TENANT’S USE OF PREMISES: life-science uses 

  

	(18)	PARKING SPACES: 

  

	(19)	BROKERS: 

  

			
	Landlord’s Broker:	  	Cornish & Carey Commercial Newmark Knight Frank
		
	Tenant’s Broker:	  	Jones Lang LaSalle

 1.02    ENUMERATION OF EXHIBITS & RIDER(S) 

The Exhibits and Rider(s) set forth below and attached to this Lease are incorporated in this Lease by this reference. 

 

			
		
	EXHIBIT A	  	Plan of Premises
		
	EXHIBIT B	  	Workletter Agreement
		
	EXHIBIT C	  	Site Plan of Project
		
	EXHIBIT D	  	Permitted Hazardous Material
		
	EXHIBIT E	  	Fair Market Rental Rate
		
	EXHIBIT F	  	Exterior Building Sign
		
	EXHIBIT G	  	Temporary Space
		
	RIDER 1	  	Commencement Date Agreement
		
	RIDER 2	  	Additional Provisions

  
 2 

 1.03    DEFINITIONS 

For purposes hereof, the following terms shall have the following meanings: 

ADJUSTMENT YEAR: The applicable calendar year or any portion thereof after the Commencement Date of this Lease for which a Rent Adjustment computation is
being made. 
 AFFILIATE: Any Person (as defined below) which is controlled by, controls, or is under common control with Tenant. The word Person means an
individual, partnership, trust, corporation, limited liability company, firm or other entity. For purposes of this definition, the word “control,” means, with respect to a Person that is a corporation or a limited liability company, the
right to exercise, directly or indirectly, more than fifty percent (50%) of the voting rights attributable to the shares or membership interests of the controlled Person and, with respect to a Person that is not a corporation, the possession,
directly or indirectly, of the power at all times to direct or cause the direction of the management of the controlled Person. 
 BUILDING: Each building in
which the Premises is located, as specified in Section 1.01(1). 
 BUILDING OPERATING EXPENSES: Those Operating Expenses described in
Section 4.01. 
 COMMENCEMENT DATE: The date specified in Section 1.01(6) as the Projected Commencement Date, unless changed by operation of
Article Two or Rider 2. 
 COMMON AREAS: All areas of the Project made available by Landlord from time to time for the general common use or benefit of the
tenants of the Building or Project, and their employees and invitees, or the public, as such areas currently exist and as they may be changed from time to time. 

DECORATION: Tenant Alterations which do not require a building permit and which do not affect the facade or roof of the Building, or involve any of the
structural elements of the Building, or involve any of the Building’s systems, including its electrical, mechanical, plumbing, security, heating, ventilating, air-conditioning, communication, and fire and
life safety systems. 
 DEFAULT RATE: Two (2) percentage points above the rate then most recently announced by Bank of America N.T. & S.A. at
its San Francisco main office as its corporate base lending rate, from time to time announced, but in no event higher than the maximum rate permitted by Law. 

DELIVERY DATE: The date for Landlord’s delivery to Tenant of possession of the Premises, if different from the Commencement Date, as provided in Rider 2.

 ENVIRONMENTAL LAWS: All Laws governing the use, storage, transportation, disposal or generation of any Hazardous Material, or pertaining to environmental
conditions on, under or about the Premises or any part of the Project, including the Comprehensive Environmental Response Compensation and Liability Act of 1980 (42 U.S.C. Section 9601 et seq.), the Resource Conservation and Recovery Act of
1976 (42 U.S.C. Section 6901 et seq.), the Hazardous Materials Transportation Act (49 U.S.C. Section 1801, et seq.); and Section 307 (33 U.S.C. Section 1317) and Section 311 (33 U.S.C. Section 1321) of the Clean Water
Act of 1977 (33 U.S.C. Section 1251, et seq..-all as heretofore or hereafter amended. 
 EXPIRATION DATE: The
date specified in Section 1.01(7) unless changed by operation of Article Two. 
 FORCE MAJEURE: Any accident, casualty, act of God, war or civil
commotion, strike or labor troubles, or any cause whatsoever beyond the reasonable control of Landlord, including water shortages, energy shortages or governmental preemption in connection with an act of God, a national emergency, or by reason of
Law, or by reason of the conditions of supply and demand which have been or are affected by act of God, war or other emergency. 
 HAZARDOUS MATERIAL: Such
substances, material and wastes which are or become regulated under any Law pertaining to environmental conditions, or which are classified as hazardous, toxic, medical waste or bio-hazardous waste under any
Law; and explosives, firearms, ammunition, flammable materials, radioactive material, asbestos, polychlorinated biphenyls, acids, caustics, gasoline, kerosene, natural gas, propane, oil, petroleum, petroleum products and by-products. Hazardous Material shall include by way, of illustration, and without limiting the generality of the foregoing, the following: (i) those substances included within the definitions of
“hazardous substances,” “hazardous materials,” “toxic substances” or “solid waste” under all present and future Laws relating to the protection 

  
 3 

 
of human health or the environment, including California Senate Bill 245 (Statutes of 1987, Chapter 1302): the Safe Drinking Water and Toxic Enforcement Act of 1986 (commonly known as Proposition
65); the Comprehensive Environmental Response, Compensation and Liability Act of 1980 (42 U.S.C. Section 9601 et seq.); the Resource Conservation and Recovery Act of 1976 (42 U.S.C. Section 6901 et seq.); the Hazardous Materials
Transportation Act (49 U.S.C. Sections 1801, et seq.); Section 307 (33 U.S.C. Section 1317) or Section 311 (33 U.S.C. Section 1321) of the Clean Water Act of 1977 (33 U.S.C. Section 1251, et seq.), all as heretofore and
hereafter amended, or in any regulations promulgated pursuant to said laws; (ii) those substances defined as “hazardous wastes” in Section 25117 of the California Health & Safety Code or as “hazardous
substances” in Section 25316 of the California Health & Safety Code, all as heretofore and hereafter amended, or in any regulations promulgated pursuant to said laws; (iii) those substances listed in the United States
Department of Transportation Table (49 CFR 172.101 and amendments thereto) or designated by the Environmental Protection Agency (or any successor agency) as hazardous substances (see, e.g., 40 CFR Part 302 and amendments thereto); and (iv) such
other substances, materials and wastes which are or become regulated under applicable local, state or federal law or by the United States government or which are or become classified as hazardous or toxic under federal, state or local laws or
regulations, including California Health & Safety Code, Division 20, and Title 26 of the California Code of Regulations, all as heretofore and hereafter amended, or in any regulations promulgated pursuant to said laws. 

INDEMNITEES: Collectively, Landlord, any Mortgagee or ground lessor of the Property, the property manager and the leasing manager tor the Property and their
respective directors, officers, agents and employees. 
 LAND: The parcel(s) of real estate on which the Building and Project are located. 

LANDLORD WORK: The construction or installation of improvements to be furnished by Landlord, if any, specifically described in Rider 2 attached hereto. 

LAWS OR LAW: All laws, ordinances, rules, regulations, other requirements, orders, rulings or decisions adopted or made by any governmental body, agency,
department or judicial authority having jurisdiction over the Property, the Premises or Tenant’s activities at the Premises and any covenants, conditions or restrictions of record which affect the Property, all as heretofore or hereafter
adopted, made or amended. 
 LEASE: This instrument and all exhibits and riders attached hereto, as may be amended from time to time. 

LEASE YEAR: The twelve month period beginning on the first day of the first month following the Commencement Date (unless the Commencement Date is the first
day of a calendar month in which case beginning on the Commencement Date), and each subsequent twelve month, or shorter, period until the Expiration Date. 

MONTHLY BASE RENT: The monthly rent specified in Section 1.01(8). 

MORTGAGEE: Any holder of a mortgage, deed of trust or other security instrument encumbering the Property. 

NATIONAL HOLIDAYS: New Year’s Day, Memorial Day, Independence Day, Labor Day, Thanksgiving Day and Christmas Day and other holidays recognized by the
Landlord and the janitorial and other unions servicing the Building in accordance with their contracts. 
 OPERATING EXPENSES: All Taxes, costs, expenses
and disbursements of every kind and nature which Landlord shall pay or become obligated to pay in connection with the ownership, management, operation, maintenance, replacement and repair of the Property (including the amortized portion of any
capital expenditure or improvement, amortized over its useful life as reasonable determined by Landlord in its reasonable discretion using general accepted accounting principles, together with interest thereon, expenses of changing utility service
providers, and any dues, assessments and other expenses pursuant to any covenants, conditions and restrictions, or any reciprocal easements, or any owner’s association now or hereafter affecting the Project). Operating Expenses shall be
allocated among the categories of Project Operating Expenses, Building Operating Expenses or Phase Operating Expenses as provided in Article Four. If any Operating Expense, though paid in one year, relates to more than one calendar year, at the
option of Landlord such expense may be proportionately allocated among such related calendar years. Operating Expenses shall include the following, by way of illustration only and not limitation: (1) all Taxes: (2) all insurance premiums
and other costs (including deductibles), including the cost of rental insurance; (3) all license, permit and inspection fees; (4) all costs of utilities, fuels and related services, including water, sewer, light, telephone, power and steam
connection, service and related charges; (5) all costs to repair, maintain and operate heating, ventilating and air conditioning systems, including preventive maintenance: (6) all janitorial, landscaping and security services; (7) all
wages, salaries, payroll taxes, fringe benefits and other labor costs, including the cost of workers’ compensation and disability insurance; (8) all costs of operation, maintenance and repair of all parking facilities and

  
 4 

 
other common areas; (9) all supplies, materials, equipment and tools: (10) dues, assessments and other expenses pursuant to any covenants, conditions and restrictions, or any reciprocal
easements, or any owner’s association now or hereafter affecting the Project; (11) modifications to the Building or the Project occasioned by Laws now or hereafter in effect: (12) the total charges of any independent contractors
employed in the care, operation, maintenance, repair, leasing and cleaning of the Project, including landscaping, roof maintenance, and repair, maintenance and monitoring of life-safety systems, plumbing systems, electrical wiring and Project
signage; (13) the cost of accounting services necessary to compute the rents and charges payable by tenants at the Project; (14) exterior window and exterior wall cleaning and painting; (15) managerial and administrative expenses;
(16) all costs in connection with the exercise facility at the Project; (17) all costs and expenses related to Landlord’s retention of consultants in connection with the routine review, inspection, testing, monitoring, analysis and
control of Hazardous Material, and retention of consultants in connection with the clean-up of Hazardous Material (to the extent not recoverable from a particular tenant of the Project), and all costs and
expenses related to the implementation of recommendations made by such consultants concerning the use, generation, storage, manufacture, production, storage, release, discharge, disposal or clean-up of
Hazardous Material on, under or about the Premises or the Project (to the extent not recoverable from a particular tenant of the Project); (18) all capital improvements made for the purpose of reducing or controlling other Operating Expenses, and
all other capital expenditures, but only as amortized over its useful life as Landlord shall reasonably determine using generally accepted real estate accounting practices, together with interest thereon; (19) all property management costs and
fees, including all costs in connection with the Project property management office, provided that management costs and fees do not exceed three percent (3%) of gross rents for the Project; and (20) all fees or other charges incurred in
conjunction with voluntary or involuntary membership in any energy conservation, air quality, environmental, traffic management or similar organizations. Operating Expenses shall not include: (a) costs of alterations of space to be occupied by
new or existing tenants of the Project; (b) depreciation charges: (c) interest and principal payments on loans (except for loans for capital expenditures or improvements which Landlord is allowed to include in Operating Expenses as
provided above); (d) ground rental payments; (e) real estate brokerage and leasing commissions; (f) advertising and marketing expenses; (g) costs of Landlord reimbursed by insurance proceeds; (h) expenses incurred in negotiating
leases of other tenants in the Project or enforcing lease obligations of other tenants in the Project; (i) capital improvements except as expressly provided above; (j) Landlord’s or Landlord’s property manager’s corporate
general overhead or corporate general administrative expenses; (k) any capital expenditure for improvements or modifications to the Building or Project to the extent that the Building or Project was in violation of Law then in effect and
applied to the Building and Project prior to execution of the Lease for failure to make such improvements or modifications prior to execution of the Lease; and (I) costs of removal, abatement or remediation of Hazardous Material to the extent
that the Building or Project was in violation of Law then in effect and applied to the Building or Project prior to execution of the Lease for failure to remove, abate or otherwise remediate Hazardous Material prior to execution of the Lease or
otherwise due to the presence of Hazardous Material. 
 PHASE: Phase means any individual Phase of the Project, as more particularly described in the
definition of Project. PHASE OPERATING EXPENSES: Those Operating Expenses described in Section 4.01. 
 PREMISES: The space located in the Building at
the Suite Number listed in Section 1.01(15) and depicted on Exhibit A attached hereto. 
 PROJECT or PROPERTY; As of the date hereof, the Project is
known as Seaport Centre and consists of those buildings (including the Building) whose general location is shown on the Site Plan of the Project attached as Exhibit C, located in Redwood City, California, associated vehicular and parking areas,
landscaping and improvements, together with the Land, any associated interests in real property, and the personal property, fixtures, machinery, equipment, systems and apparatus located in or used in conjunction with any of the foregoing. The
Project may also be referred to as the Property. As of the date hereof, the Project is divided into Phase I and Phase II, which are generally designated on Exhibit C, each of which may individually be referred to as a Phase. Landlord reserves the
right from time to time to add or remove buildings, areas and improvements to or from a Phase or the Project, or to add or remove a Phase to or from the Project. In the event of any such addition or removal which affects Rentable Area of the Project
or a Phase, Landlord shall make a corresponding recalculation and adjustment of any affected Rentable Area and Tenant’s Share. 
 PROJECT OPERATING
EXPENSES: Those Operating Expenses described in Section 4.01. REAL PROPERTY: The Property excluding any personal property. 
 RENT: Collectively,
Monthly Base Rent, Rent Adjustments and Rent Adjustment Deposits, and all other charges, payments, late fees or other amounts required to be paid by Tenant under this Lease. 

  
 5 

 RENT ADJUSTMENT: Any amounts owed by Tenant for payment of Operating Expenses. The Rent Adjustments shall be
determined and paid as provided in Article Four. 
 RENT ADJUSTMENT DEPOSIT: An amount equal to Landlord’s estimate of the Rent Adjustment attributable
to each month of the applicable Adjustment Year. On or before the Commencement Date and the beginning of each subsequent Adjustment Year or with Landlord’s Statement (defined in Article Four), Landlord may estimate and notify Tenant in writing
of its estimate of Operating Expenses, including Project Operating Expenses, Building Operating Expenses and Phase Operating Expenses, and Tenant’s Share of each, for the applicable Adjustment Year. The Rent Adjustment Deposit applicable for
the calendar year in which the Commencement Date occurs shall be the amount, if any, specified in Section 1.01(9). Landlord shall have the right from time to time during any Adjustment Year to provide a new or revised estimate of Operating
Expenses and/or Taxes and to notify Tenant in writing thereof, of corresponding adjustments in Tenant’s Rent Adjustment Deposit payable over the remainder of such year, and the amount or revised amount due allocable to months preceding such
change. The last estimate by Landlord shall remain in effect as the applicable Rent Adjustment Deposit unless and until Landlord notifies Tenant in writing of a change. 

RENTABLE AREA OF THE BUILDING: The amount of square footage set forth in Section 1.01(11) 

RENTABLE AREA OF THE PHASE: The amount of square footage set forth in Section 1.01(12) RENTABLE AREA OF THE PREMISES: The amount of square footage set
forth in Section 1.01(10): 
 RENTABLE AREA OF THE PROJECT: The amount of square footage set forth in Section 1.01(13), which represents the sum
of the rentable area of all space intended for occupancy in the Project. 
 SECURITY: The cash, if any, specified in Section 1.01 as Security paid
and/or delivered to Landlord as security for Tenant’s performance of its obligations under this Lease, all as more particularly provided in Article Five. 

SUBSTANTIALLY COMPLETE or SUBSTANTIAL COMPLETION: The completion of the Landlord Work or Tenant Work, as the case may be, except for minor insubstantial
details of construction, decoration or mechanical adjustments which remain to be done. 
 TAXES: All federal, state and local governmental taxes,
assessments (including assessment bonds) and charges of every kind or nature, whether general, special, ordinary or extraordinary, which Landlord shall pay or become obligated to pay because of or in connection with the ownership, leasing,
management, control or operation of the Property or any of its components (including any personal property used in connection therewith), which may also include any rental or similar taxes levied in lieu of or in addition to general real and/or
personal property taxes. For purposes hereof, Taxes for any year shall be Taxes which are assessed for any period of such year, whether or not such Taxes are billed and payable in a subsequent calendar year. There shall be included in Taxes for any
year the amount of all fees, costs and expenses (including reasonable attorneys’ fees) paid by Landlord during such year in seeking or obtaining any refund or reduction of Taxes. Taxes for any year shall be reduced by the net amount of any tax
refund received by Landlord attributable to such year. If a special assessment payable in installments is levied against any part of the Property, Taxes for any year shall include only the installment of such assessment and any interest payable or
paid during such year. Taxes shall not include any federal or state inheritance, general income, gift or estate taxes, except that if a change occurs in the method of taxation resulting in whole or in part in the substitution of any such taxes, or
any other assessment, for any Taxes as above defined, such substituted taxes or assessments shall be included in the Taxes. 
 TENANT ADDITIONS:
Collectively, Landlord Work, Tenant Work and Tenant Alterations. 
 TENANT ALTERATIONS: ALTERATIONS: Any alterations, improvements, additions, installations
or construction in or to the Premises or any Real Property systems serving the Premises done or caused to be done by Tenant after the date hereof, whether prior to or after the Commencement Date (including Tenant Work, but excluding Landlord Work).

 TENANT DELAY: Any event or occurrence which delays the Substantial Completion of the Landlord Work which is caused by or is described as follows: 

(i)    special work, changes, alterations or additions requested or made by Tenant in the design or finish in any part of
the Premises after approval of the plans and specifications (as described in the Rider 2); 

  
 6 

 (ii)    Tenant’s delay in submitting plans, supplying information,
approving plans, specifications or estimates, giving authorizations or otherwise: 
 (iii)    failure to approve and pay
for such work, if any, as Landlord undertakes to complete at Tenant’s expense: 
 (iv)    the performance or
completion by Tenant or any person engaged by Tenant of any work in or about the Premises; or 
 (v)    failure to
perform or comply with any obligation or condition binding upon Tenant pursuant to Rider 2, including the failure to approve and pay for such Landlord Work or other items if and to the extent Rider 2 provides they are to be approved or
paid by Tenant. 
 TENANT WORK: All work installed or furnished to the Premises by Tenant in connection with Tenant’s initial occupancy pursuant to
Rider 2 and the Workletter. 
 TENANT’S BUILDING SHARE: The share as specified in Section 1.01(16) and Section 4.01. TENANT’S PHASE: The
Phase in which the Premises is located, as indicated in Section 1.01(1). TENANT’S PHASE SHARE: The share as specified in Section 1.01(16) and Section 4.01. TENANT’S PROJECT SHARE: The share as specified in
Section 1.01(16) and Section 4.01. 
 TENANT’S SHARE: Shall mean collectively, Tenant’s respective shares of the respective categories
of Operating Expenses, as provided in Section 1.01(16) and Section 4.01. If this Lease is of Premises in more than one building of the Project, then Tenant’s Building Share shall be calculated and specified separately for each such
building. 
 TERM: The term of this Lease commencing on the Commencement Date and expiring on the Expiration Date 

TERMINATION DATE: The Expiration Date or such earlier date as this Lease terminates or Tenant’s right to possession of the Premises terminates. 

WORKLETTER: The agreement regarding the condition of the Premises and Building, and completion of Tenant Work and Landlord Work, if any, set forth in Rider 2
and/or Exhibit B hereto. 
 ARTICLE TWO 

PREMISES, TERM, FAILURE TO GIVE POSSESSION, COMMON AREAS AND PARKING 

2.01    LEASE OF PREMISES 
  

	2.02    AREA	OF PREMISES 

 Landlord and Tenant agree that for all purposes of this Lease the Rentable Area of the Premises,
the Rentable Area of the Building, the Rentable Area of the Phase and the Rentable Area of the Project as set forth in Article One are controlling, and are not subject to revision after the date of this Lease, except as otherwise provided herein.

 2.03    CONDITION OF PREMISES (See Rider 
  

	2.04    COMMON	AREAS & PARKING 

 (a)    Right to Use Common Areas. Tenant
shall have the non-exclusive right, in common with others, to the use of any common entrances, ramps, drives and similar access and serviceways and other Common Areas in the Project. The rights of Tenant
hereunder in and to the Common Areas shall at all times be subject to the rights of Landlord and other tenants and owners in the Project who use the same in common with Tenant, and it shall be the duty of Tenant to keep all the Common Areas free and
clear of any obstructions created or permitted by Tenant or resulting from Tenant’s operations. Tenant shall not use the Common Areas or common facilities of the Building or the Project, including the Building’s electrical room, parking
lot or trash enclosures, for storage purposes. Nothing herein shall affect the right of Landlord at any time to remove any persons not authorized to use the Common Areas or common facilities from such areas or facilities or to prevent their use by
unauthorized persons. 

  
 7 

 (b)    Changes in Common Areas. Landlord reserves the right, at any
time and from time to time to (i) make alterations in or additions to the Common Areas or common facilities of the Project, including constructing new buildings or changing the location, size, shape or number of the driveways, entrances,
parking spaces, parking areas, loading and unloading areas, landscape areas and walkways, (ii) designate property to be included in or eliminate property from the Common Areas or common facilities of the Project, (iii) close temporarily
any of the Common Areas or common facilities of the Project for maintenance purposes, and (4) use the Common Areas and common facilities of the Project while engaged in making alterations in or additions and repairs to the Project; provided,
however, that reasonable access to the Premises and parking at or near the Project remains available. 

(c)    Parking. During the Term, Tenant shall have the right to use the number of Parking Spaces specified in
Section 1.01(18) for parking on an unassigned basis on that portion of the Project designated by Landlord from time to time for parking. Tenant acknowledges and agrees that the parking spaces in the Project’s parking facility may include a
mixture of spaces for compact vehicles as well as full-size passenger automobiles, and that Tenant shall not use parking spaces for vehicles larger than the striped size of the parking spaces. Tenant shall not
park any vehicles at the Project; overnight. Tenant shall comply with any and all parking rules and regulations if and as from time to time established by Landlord. Tenant shall not allow any vehicles using Tenant’s parking privileges to be
parked, loaded or unloaded except in accordance with this Section, including in the areas and in the manner designated by Landlord for such activities. If any vehicle is using the parking or loading areas contrary to any provision of this Section,
Landlord shall have the right, in addition to all other rights and remedies of Landlord under this Lease, to remove or tow away the vehicle without prior notice to Tenant, and the cost thereof shall be paid to Landlord within twenty (20) days
after notice from Landlord to Tenant. 
 ARTICLE THREE 

RENT 
 Tenant agrees to pay to Landlord at the
first office specified in Section 1.01(2), or to such other persons, or at such other places designated by Landlord, without any prior demand therefor in immediately available funds and without any deduction or offset whatsoever, Rent,
including Monthly Base Rent and Rent Adjustments in accordance with Article Four, during the Term. Monthly Base Rent shall be paid monthly in advance on the first day of each month of the Term, except that the first installment of Monthly Base Rent
shall be paid by Tenant to Landlord simultaneously with Tenant’s execution and delivery of this Lease to Landlord. Monthly Base Rent shall be prorated for partial months within the Term. Unpaid Rent shall bear interest at the Default Rate from
the date due until paid. Tenant’s covenant to pay Rent shall be independent of every other covenant in this Lease. 
 ARTICLE FOUR 

OPERATING EXPENSES, RENT ADJUSTMENTS AND PAYMENTS 

4.01    TENANT’S SHARE OF OPERATING EXPENSES 

Tenant shall pay Tenant’s Share of Operating Expenses in the respective shares of the respective categories of Operating Expenses as set forth below. 

(a)    Tenant’s Project Share of Project Operating Expenses, which is the percentage obtained by dividing the
rentable square footage of the Premises for the building(s) in which the Premises is located by the rentable square footage of the Project and as of the date hereof equals the percentage set forth in Section 1.01(16); 

(b)    Tenant’s Building Share of Building Operating Expenses, which is the percentage obtained by dividing the
rentable square footage of the Premises respectively for each building in which the Premises is located by the total rentable square footage of such building and as of the date hereof equals the percentage set forth in Section 1.01(16): 

(c)    Tenant’s Phase Share of Phase Operating Expenses, which is the percentage obtained by dividing the aggregate
rentable square footage of the Premises located in Tenant’s Phase by the total rentable square footage of Tenant’s Phase and as of the date hereof equals the percentage set forth in Section 1.01(16); 

(d)    Project Operating Expenses shall mean all Operating Expenses that are not included as Phase Operating Expenses
(defined below) and that are not either Building Operating Expenses or operating expenses directly and separately identifiable to the operation, maintenance or repair of any other building located in the Project, but Project Operating Expenses
includes operating expenses allocable to any areas of the Building or any other building during such time as such areas are made available by Landlord for the general common use or benefit of all tenants of the Project, and their employees and
invitees, or the public, as such areas currently exist and as they may be changed from time to time; 

  
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 (e)    Building Operating Expenses shall mean Operating Expenses that are
directly and separately identifiable to each building in which the Premises or part thereof is located: 
 (f)    Phase
Operating Expenses shall mean Operating Expenses that Landlord may allocate to a Phase as directly and separately identifiable to all buildings located in the Phase (including but not limited to the Building) and may include Project Operating
Expenses that are separately identifiable to a Phase; 
 (g)    Landlord shall have the right to allocate a particular
item or portion of Operating Expenses as any one of Project Operating Expenses, Building Operating Expenses or Phase Operating Expenses; however, in no event shall any portion of Building Operating Expenses, Project Operating Expenses or Phase
Operating Expenses be assessed or counted against Tenant more than once; and. 
 (h)    Notwithstanding anything to the
contrary contained in this Section 4.01, as to each specific category of Operating Expense which one or more tenants of the Building either pays directly to third parties or specifically reimburses to Landlord (for example, separately
contracted janitorial services or property taxes directly reimbursed to Landlord), then, on a category by category basis, the amount of Operating Expenses for the affected period shall be adjusted as follows: (1) all such tenant payments with
respect to such category of expense and all of Landlord’s costs reimbursed thereby shall be excluded from Operating Expenses and Tenants Building Share, Tenant’s Phase Share or Tenant’s Project Share, as the case may be, for such
category of Operating Expense shall be adjusted by excluding the square footage of all such tenants, and (2) if Tenant pays or directly reimburses Landlord for such category of Operating Expense, such category of Operating Expense shall be
excluded from the determination of Operating Expenses for the purposes of this Lease. 
 4.02    RENT ADJUSTMENTS 

Tenant shall pay to Landlord Rent Adjustments with respect to each Adjustment Year as follows: 

(a)    The Rent Adjustment Deposit shall be paid monthly during the Term with the payment of Monthly Base Rent, except the
first installment which shall be paid by Tenant to Landlord concurrently with execution of this Lease. The Rent Adjustment Deposit represents, on a monthly basis, Tenant’s Share of Landlord’s estimate of Operating Expenses, as described in
Section 4.01, for the applicable Adjustment Year (or portion thereof): and 
 (b)    Any Rent Adjustments due in
excess of the Rent Adjustment Deposits in accordance with Section 4.03. 
 4.03    STATEMENT OF LANDLORD 

Within one hundred twenty (120) days after the end of each calendar year or as soon thereafter as reasonably possible, Landlord will furnish Tenant a
statement (“Landlord’s Statement”) showing the following: 
 (a)    Operating Expenses for the last
Adjustment Year showing in reasonable detail the actual Operating Expenses categorized among Project Operating Expenses, Building Operating Expenses and Phase Operating Expenses for such period and Tenant’s Share of each as described in
Section 4.01 above; 
 (b)    The amount of Rent Adjustments due Landlord for the last Adjustment Year, less credit
for Rent Adjustment Deposits paid, if any: and 
 (c)    Any change in the Rent Adjustment Deposit due monthly in the
current Adjustment Year, including the amount or revised amount due for months preceding any such change pursuant to Landlord’s Statement. 
 Tenant
shall pay to Landlord within twenty (20) days after receipt of such statement arty amounts for Rent Adjustments then due in accordance with Landlord’s Statement. Any amounts due from Landlord to Tenant pursuant to this Section shall be
credited to the Rent Adjustment Deposit next coming due, or refunded to Tenant if the Term has already expired provided Tenant is not in default hereunder. No interest or penalties shall accrue on any amounts which Landlord is obligated to credit or
refund to Tenant by reason of this Section 4.03. Landlord’s failure to deliver Landlord’s Statement or to compute the amount of the Rent Adjustments shall not constitute a waiver by Landlord of its right to deliver such items nor
constitute a waiver or release of Tenant’s obligations to pay such amounts, provided 

  
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Landlord’s Statement is received within three (3) years after the end of the Adjustment Year to which the Landlord’s Statement applies. The Rent Adjustment Deposit shall be
credited against Rent Adjustments due for the applicable Adjustment Year. During the last complete calendar year or during any partial calendar year in which the Lease terminates, Landlord may include in the Rent Adjustment Deposit its estimate of
Rent Adjustments which may not be finally determined until after the termination of this Lease. Tenant’s obligation to pay Rent Adjustments survives the expiration or termination of the Lease. Notwithstanding the foregoing, in no event shall
the sum of Monthly Base Rent and the Rent Adjustments be less than the Monthly Base Rent payable. 
 4.04    BOOKS AND RECORDS 

Landlord shall maintain books and records showing Operating Expenses and Taxes in accordance with sound accounting and management practices, consistently
applied. The Tenant or its representative (which representative shall be a certified public accountant licensed to do business in the state in which the Property is located and whose primary business is certified public accounting) shall have the
right, for a period of thirty (30) days following the date upon which Landlord’s Statement is delivered to Tenant, to examine the Landlords books and records with respect to the items in the foregoing statement of Operating Expenses and
Taxes during normal business hours, upon written notice, delivered at least three (3) business days in advance. If Tenant does not object in writing to Landlord’s Statement within sixty (60) days of Tenant’s receipt thereof,
specifying the nature of the item in dispute and the reasons therefor, then Landlord’s Statement shall be considered final and accepted by Tenant. Any amount due to the Landlord as shown on Landlord’s Statement, whether or not disputed by
Tenant as provided herein shall be paid by Tenant when due as provided above, without prejudice to any such written exception. 

4.05    TENANT OR LEASE SPECIFIC TAXES 
 In
addition to Monthly Base Rent, Rent Adjustments, Rent Adjustment Deposits and other charges to be paid by Tenant, Tenant shall pay to Landlord, upon demand, any and all taxes payable by Landlord (other than federal or state inheritance, general
income, gift or estate taxes) whether or not now customary or within the contemplation of the parties hereto: (a) upon, allocable to, or measured by the Rent payable hereunder, including any gross receipts tax or excise tax levied by any
governmental or taxing body with respect to the receipt of such rent: or (b) upon or with respect to the possession, leasing, operation, management, maintenance, alteration, repair, use or occupancy by Tenant of the Premises or any portion
thereof; or (c) upon the measured value of Tenant’s personal property or trade fixtures located in the Premises or in any storeroom or any other place in the Premises or the Property, or the areas used in connection with the operation of
the Property, it being the intention of Landlord and Tenant that, to the extent possible, Tenant shall cause such taxes on personal property or trade fixtures to be billed to and paid directly by Tenant; (d) resulting from Landlord Work, Tenant
Work or Tenant Alterations to the Premises, whether title thereto is in Landlord or Tenant; or (e) upon this transaction. Taxes paid by Tenant pursuant to this Section 4.05 shall not be included in any computation of Taxes as part of
Operating Expenses. 
 ARTICLE FIVE 

SECURITY 

(a)    Simultaneously with Tenant’s execution and delivery of this Lease to Landlord, Tenant shall pay Landlord in
immediately available funds the cash amount of the Security specified in Section 1.01 as security (“Security”) for the full and faithful performance by Tenant of each and every term, provision, covenant, and condition of this Lease.
If Tenant fails timely to perform any of the terms, provisions, covenants and conditions of this Lease or any other document executed by Tenant in connection with this Lease, including, but not limited to, the payment of Rent or the repair of damage
to the Premises caused by Tenant (excluding normal wear and tear), then Landlord may use, apply, or retain the whole or any part of the Security for the payment of any Rent not paid when due, for the cost of repairing such damage, for the cost of
cleaning the Premises, for the payment of any other sum which Landlord may expend or may be required to expend by reason of Tenant’s failure to perform, and otherwise for compensation of Landlord for any other loss or damage to Landlord
occasioned by Tenant’s failure to perform, including, but not limited to, any loss of future Rent and any damage or deficiency in the reletting of the Premises (whether such loss, damages or deficiency accrue before or after summary proceedings
or other reentry by Landlord) and the amount of the unpaid past Rent, future Rent loss, and all other losses, costs and damages, that Landlord would be entitled to recover if Landlord were to pursue recovery under Section 11.02(b) or
(c) of this Lease or California Civil Code Section 1951.2 or 1951.4 (and any supplements, amendments, replacements and substitutions thereof and therefor from time to time). If Landlord so uses, applies or retains all or part of the
Security, Tenant shall within five (5) business days after demand pay or deliver to Landlord in immediately available funds the sum necessary to replace the amount used, applied or retained. If Tenant has fully and faithfully performed and
observed all of Tenant’s obligations under the terms, provisions, covenants and conditions of this Lease, the Security (except any amount retained for application by Landlord as provided herein) shall be returned or paid over to Tenant no later
than ninety 

  
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(90) days after the latest of: (i) the Termination Date: (ii) the removal of Tenant from the Premises; or (iii) the surrender of the Premises by Tenant to Landlord in accordance
with this Lease. Provided, however, in no event shall any such return be construed as an admission by Landlord that Tenant has performed all of its obligations hereunder. 

(b)    The Security shall not be deemed an advance rent deposit or an advance payment of any kind, or a measure of
Landlord’s damages with respect to Tenant’s failure to perform, nor shall any action or inaction of Landlord with respect to it or its use or application be a waiver of, or bar or defense to, enforcement of any right or remedy of Landlord.
Landlord shall not be required to keep the Security separate from its general funds and shall not have any fiduciary duties or other duties (except as set forth in this Section) concerning the Security. Tenant shall not be entitled to any interest
on the Security. In the event of any sale, lease or transfer of Landlord’s interest in the Building, Landlord shall have the right to transfer the Security, or balance thereof, to the vendee, transferee or lessee and any such transfer shall
release Landlord from all liability for the return of the Security. Tenant thereafter shall look solely to such vendee, transferee or lessee for the return or payment of the Security. Tenant shall not assign or encumber or attempt to assign or
encumber the Security or any interest in it and Landlord shall not be bound by any such assignment, encumbrance, attempted assignment or attempted encumbrance, and regardless of one or more assignments of this Lease, Landlord may return the Security
to the original Tenant without liability to any assignee. Tenant hereby waives any and all rights of Tenant under the provisions of Section 1950.7 of the California Civil Code (excluding subsection (b) of California Civil Code
Section 1950.7), and any and all rights of Tenant under all provisions of Law, now or hereafter enacted, regarding security deposits. 

(c)    If Tenant fails timely to perform any obligation under this Article Five, such breach shall constitute a Default by
Tenant under this Lease without any right to or requirement of any, further notice or cure period under any other Article of this Lease, except such notice and cure period expressly provided under this Article Five. 

ARTICLE SIX 
 UTILITIES &
SERVICES 
 6.01    LANDLORD’S GENERAL SERVICES 

Landlord shall provide maintenance and services as provided in Article Eight. 

6.02    TENANT TO OBTAIN & PAY DIRECTLY 

(a)    Tenant shall be responsible for and shall pay promptly all charges for gas, electricity, sewer, heat, light, power,
telephone, refuse pickup (to be performed on a regularly scheduled basis so that accumulated refuse does not exceed the capacity of Tenant’s refuse bins), janitorial service and all other utilities, materials and services furnished directly to
or used by Tenant in, on or about the Premises, together with all taxes thereon. Tenant shall contract directly with the providing companies for such utilities and services. 

(b)    Notwithstanding any provision of the Lease to the contrary, without, in each instance, the prior written consent of
Landlord, as more particularly provided in Article Nine, Tenant shall not: (i) make any alterations or additions to the electric or gas equipment or systems or other Building systems. Tenant’s use of electric current shall at no time
exceed the capacity of the wiring, feeders and risers providing electric current to the Premises or the Building. The consent of Landlord to the installation of electric equipment shall not relieve Tenant from the obligation to limit usage of
electricity to no more than such capacity. 
 6.03    TELEPHONE SERVICES 

All telegraph, telephone, and communication connections which Tenant may desire outside the Premises shall be subject to Landlord’s prior written
approval, in Landlord’s sole discretion, and the location of all wires and the work in connection therewith shall be performed by contractors approved by Landlord and shall be subject to the direction of Landlord, except that such approval is
not required as to Tenant’s cabling from the Premises in a route designated by Landlord to any telephone cabinet or panel provided for Tenant’s connection to the telephone cable serving the Building, so long as Tenant’s equipment does
not require connections different than or additional to those to the telephone cabinet or panel provided. As to any such connections or work outside the Premises requiring Landlord’s approval, Landlord reserves the right to designate and
control the entity or entities providing telephone or other communication cable installation, removal, repair and maintenance outside the Premises and to restrict and control access to telephone cabinets or panels. In the event Landlord designates a
particular vendor or vendors to provide such cable installation, removal, repair and maintenance for the Building, Tenant agrees to abide by and participate in such program. Tenant shall be responsible for and shall pay all costs incurred in
connection with the installation of telephone cables and communication wiring in the Premises, including any hook-up, access and maintenance fees 

  
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related to the installation of such wires and cables in the Premises and the commencement of service therein, and the maintenance thereafter of such wire and cables: and there shall be included
in Operating Expenses for the Building all installation, removal, hook-up or maintenance costs incurred by Landlord in connection with telephone cables and communication wiring serving the Building which are
not allocable to any individual users of such service but are allocable to the Building generally. If Tenant fails to maintain all telephone cables and communication wiring in the Premises and such failure affects or interferes with the operation or
maintenance of any other telephone cables or communication wiring serving the Building, Landlord or any vendor hired by Landlord may enter into and upon the Premises forthwith and perform such repairs, restorations or alterations as Landlord deems
necessary in order to eliminate any such interference (and Landlord may recover from Tenant all of Landlord’s costs in connection therewith). No later than the Termination Date, Tenant agrees to remove all telephone cables and communication
wiring installed by Tenant for and during Tenant’s occupancy, which Landlord shall request Tenant to remove. Tenant agrees that neither Landlord nor any of its agents or employees shall be liable to Tenant, or any of Tenant’s employees,
agents, customers or invitees or anyone claiming through, by or under Tenant, for any damages, injuries, losses, expenses, claims or causes of action because of any interruption, diminution, delay or discontinuance at any time for any, reason in the
furnishing of any telephone or other communication service to the Premises and the Building. 
 6.04    FAILURE OR INTERRUPTION OF
UTILITY OR SERVICE 
 To the extent that any equipment or machinery furnished or maintained by Landlord outside the Premises is used in the delivery of
utilities directly obtained by Tenant pursuant to Section 6.02 and breaks down or ceases to function properly, Landlord shall use reasonable diligence to repair same promptly. In the event of any failure, stoppage or interruption of, or change
in, any utilities or services supplied by Landlord which are not directly obtained by Tenant, Landlord shall use reasonable diligence to have service promptly resumed. In either event covered by the preceding two sentences, if the cause of any such
failure, stoppage or interruption of, or change in, utilities or services is within the control of a public utility, other public or quasi-public entity, or utility provider outside Landlord’s control, notification to such utility or entity of
such failure, stoppage or interruption and request to remedy the same shall constitute “reasonable diligence” by Landlord to have service promptly resumed. Notwithstanding any other provision of this Section to the contrary, in the event
of any failure, stoppage or interruption of, or change in, any utility or other service furnished to the Premises or the Project resulting from any cause, including changes in service provider or Landlord’s compliance with any voluntary or
similar governmental or business guidelines now or hereafter published or any requirements now or hereafter established by any governmental agency, board or bureau having jurisdiction over the operation of the Property: (a) Landlord shall not
be liable for, and Tenant shall not be entitled to, any abatement or reduction of Rent; (b) no such failure, stoppage, or interruption of any such utility or service shall constitute an eviction of Tenant or relieve Tenant of the obligation to
perform any covenant or agreement of this Lease to be performed by Tenant; (c) Landlord shall not be in breach of this Lease nor be liable to Tenant for damages or otherwise. 

6.05    CHOICE OF SERVICE PROVIDER 
 Tenant
acknowledges that Landlord may, at Landlord’s sole option, to the extent permitted by applicable law, elect to change, from time to time, the company or companies which provide services (including electrical service, gas service, water,
telephone and technical services) to the Property, the Premises and/or its occupants. Notwithstanding anything to the contrary set forth in this Lease, Tenant acknowledges that Landlord has not and does not make any representations or warranties
concerning the identity or identities of the company or companies which provide services to the Property and the Premises or its occupants and Tenant acknowledges that the choice of service providers and matters concerning the engagement and
termination thereof shall be solely that of Landlord. The foregoing provision is not intended to modify, amend, change or otherwise derogate from any provision of this Lease concerning the nature or type of service to be provided or any specific
information concerning the amount thereof to be provided. Tenant agrees to cooperate with Landlord and each of its service providers in connection with any change in service or provider. 

6.06    SIGNAGE 
 Tenant shall not install
any signage within the Project, the Building or the Premises without obtaining the prior written approval of Landlord, and Tenant shall be responsible for procurement, installation, maintenance and removal of any such signage installed by Tenant,
and all costs in connection therewith. Any such signage shall comply with Landlord’s current Project signage criteria and all Laws. 

  
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 ARTICLE SEVEN 

POSSESSION, USE AND CONDITION OF PREMISES 

7.01    POSSESSION AND USE OF PREMISES 

(a)    Tenant shall occupy and use the Premises only for the uses specified in Section 1.01(17) to conduct
Tenant’s business. Tenant shall not occupy or use the Premises (or permit the use or occupancy of the Premises) for any purpose or in any manner which: (1) is unlawful or in violation of any Law or Environmental Law; (2) may be
dangerous to persons or property or which may invalidate, any policy of insurance carried on the Building or Project or covering its operations or which may increase the cost of any such insurance or insurance carried by any other occupant of the
Project unless such increase is paid by Tenant; (3) is contrary to or prohibited by the terms and conditions of this Lease or the rules and regulations as provided in Article Eighteen; (4) contrary to or prohibited by the articles, bylaws
or rules of any owner’s association affecting the Project: (5) is improper, immoral, or objectionable; (6) would obstruct or interfere with the rights of other tenants or occupants of the Building or the Project, or injure or annoy
them, or would tend to create or continue a nuisance: or (7) would constitute any waste in or upon the Premises or Project. 

(b)    Landlord and Tenant acknowledge that the Americans With Disabilities Act of 1990 (42 U.S.C. §12101 et seq.)
and regulations and guidelines promulgated thereunder, as all of the same may be amended and supplemented from time to time (collectively referred to herein as the “ADA”) establish requirements for business operations, accessibility and
barrier removal, and that such requirements may or may not apply to the Premises, the Building and the Project depending on, among other things: (1) whether Tenant’s business is deemed a “public accommodation” or “commercial
facility”, (2) whether such requirements are “readily achievable”, and (3) whether a given alteration affects a “primary function area” or triggers “path of travel” requirements. The parties hereby agree that:
(a) Landlord shall be responsible for ADA Title III compliance in the Common Areas, except as provided below, (b) Tenant shall be responsible for ADA Title III compliance in the Premises, including any leasehold improvements or other work
to be performed in the Premises under or in connection with this Lease, (c) Landlord may perform, or require that Tenant perform, and Tenant shall be responsible for the cost of, ADA Title III “path of travel” requirements triggered
by Tenant Additions in the Premises, and (d) Landlord may perform, or require Tenant to perform, and Tenant shall be responsible for the cost of, ADA Title III compliance in the Common Areas necessitated by the Building being deemed to be a
“public accommodation” instead of a “commercial facility’ as a result of Tenant’s use of the Premises. To the extent Tenant shall occupy the entire Building or an entire floor in the Building, all ADA Title III requirements
relating to the restrooms, elevator lobbies and corridors on such floor shall be the responsibility of Tenant. In such event, all matters related to “life safety” on such floor shall also be the responsibility of Tenant. Tenant shall be
solely responsible for requirements under Title I of the ADA relating to Tenant’s employees. 
 (c)    Landlord and
Tenant agree to cooperate and use commercially reasonable efforts to participate in traffic management programs generally applicable to businesses located in or about the area and Tenant shall encourage and support van and car pooling by, and
staggered and flexible working hours for, its office workers and service employees to the extent reasonably permitted by the requirements of Tenant’s business. Neither this Section or any other provision of this Lease is intended to or shall
create any rights or benefits in any other person, firm, company, governmental entity or the public. 
 (d)    Tenant
agrees to cooperate with Landlord and to comply with any and all guidelines or controls concerning energy management imposed upon Landlord by federal or state governmental organizations or by any energy conservation association to which Landlord is
a party or which is applicable tope Building. 
 7.02    HAZARDOUS MATERIAL 

(a)    Tenant shall not use, generate, manufacture, produce, store, handle, release, discharge, or dispose of, on, under or
about the Premises or any part of the Project, or transport to or from the Premises or any part of the Project, any Hazardous Material or allow any “Tenant Parties” (defined below) to do so, except as expressly permitted below, without the
prior written consent of Landlord, which may be withheld in Landlord’s sole discretion. Upon demand, Tenant shall reimburse Landlord for all reasonable,
out-of-pocket costs and expenses incurred by Landlord in evaluating any such request. For purposes of this Lease, “Tenant Parties shall mean all occupants or users
of the Premises permitted or suffered by Tenant, or the employees, servants, agents, contractors, customers or invitees of Tenant or of any such occupants or users. Provided that the Premises are used only for the uses specified in Section 1.01
and Section 7.01 above, the foregoing prohibition shall not prohibit Tenant from using and storing in, and transporting to and from, the Premises, the types and amounts of Hazardous Material as specified on Exhibit D hereto and by this
reference incorporated herein (“Permitted Hazardous Material”) and insignificant amounts of Hazardous Material typically used in general business office applications (to the extent the Premises is

  
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used for general offices) so long as (i) such substances are used in accordance with the manufacturers’ instructions therefor and all applicable Laws, (ii) such substances are not
used or disposed of in or about the Building or the Project in a manner which would constitute a release or discharge thereof, and (iii) all Hazardous Material is removed from the Building and the Project by Tenant no later than the Termination
Date. Tenant shall, within fifteen (15) days after demand therefor, deliver to Landlord a written list identifying any Hazardous Material then maintained by Tenant in the Building, the use of each such Hazardous Material so maintained by Tenant
together with written certification by Tenant stating, in substance, that neither Tenant nor any Tenant Parties has released or discharged any Hazardous Material in or about the Building or the Project. 

(b)    In the event that Tenant desires to add additional quantities or types of Hazardous Material to the list of
Permitted Hazardous Material specified in Exhibit D hereto, Tenant shall give Landlord notice of the type of proposed Hazardous Material, quantity thereof, and information appropriate for review by Landlord and its consultant as to the nature,
characteristics and risks of such Hazardous Material and how Tenant proposes to store and use it. Any proposed change in the quantities or types of Permitted Hazardous Material shall be subject to the prior written consent of Landlord, which may be
withheld in Landlord’s sole discretion. Within fifteen (15) days after receipt of a duly submitted request by Tenant, Landlord shall give Tenant written notice of Landlord’s approval, disapproval or request for additional information
for Landlord to evaluate Tenant’s request, in Landlord’s sole discretion. Failure to notify Tenant in writing within said period shall be deemed disapproval by Landlord. Upon demand, Tenant shall reimburse Landlord for all reasonable out-of-pocket costs and expenses incurred by Landlord in evaluating any such request. Provided however, so long as (1) Tenant maintains a net worth (excluding any value
attributable to goodwill or going concern value) of at least Six Million Dollars ($6,000,000); and (2) the additional quantity of Permitted Hazardous Material which Tenant requests consent to use is consistent with the quantity of the subject
item of Permitted Hazardous Material originally specified on Exhibit D, and the largest container of any Permitted Hazardous Material stored or used by Tenant at the Premises shall be no larger than a fifty-five (55) gallon drum; and
(3) the additional type of Hazardous Material which Tenant requests consent to use does not have a higher or increased level of toxicity or NFPA (National Fire Protection Association) hazardous material classification than that applicable to
the most similar item of Permitted Hazardous Material originally specified on Exhibit D and the quantity of such additional item is consistent with that of the most similar item of Permitted Hazardous Material originally specified on Exhibit D; and
(4) in each case of a request for an additional quantity or type to be included as Permitted Hazardous Material (and in the aggregate for all such changes together with the previously approved Permitted Hazardous Material which Tenant still has
the right to use) the risk (including risk of injury, death, property damage, release in violation of Environmental Laws or this Lease, and costs of remediation to respond to such release) is consistent with the risk posed by the quantities and
types of Permitted Hazardous Material originally specified on Exhibit D; then, provided all the foregoing conditions precedent are satisfied, Landlord shall not unreasonably withhold consent to Tenant’s use of such additional quantity or
additional type of Hazardous Material. 
 (c)    Tenant shall, within fifteen (15) days after demand therefor,
deliver to Landlord a copy of: (x) all permits, licenses and other governmental and regulatory approvals with respect to the use, generation, manufacture, production, storage, handling, release, discharge, removal and disposal by Tenant or Any
of the Tenant Parties of Hazardous Material at the Project; and (y) each Hazardous Material management plan or similar document (“Plan(s)”) with respect to use, generation, manufacture, production, storage, handling, release,
discharge, removal or disposal of Hazardous Material by Tenant or any of the Tenant Parties necessary to comply with Environmental Laws or other Laws prepared by or on behalf of Tenant or any of the Tenant Parties (whether or not required to be
submitted to a governmental agency). Tenant shall comply with all Environmental Laws pertaining to Tenant’s occupancy and use of the Premises and concerning the proper storage, handling and disposal of any Hazardous Material introduced to the
Premises, the Building or the Property by Tenant or any Tenant Parties. Landlord shall comply with all Environmental Laws applicable to the Property other than those to be complied with by Tenant pursuant to the preceding sentence. In the event that
Tenant is notified of any investigation or violation of any Environmental Law arising from Tenant’s activities at the Premises, Tenant shall immediately deliver to Landlord a copy of such notice. In such event or in the event Landlord
reasonably believes that a violation of Environmental Law exists, Landlord may conduct such tests and studies relating to compliance by Tenant with Environmental Laws or the alleged presence of Hazardous Material upon the Premises as Landlord deems
desirable, all of which shall be completed. If such tests and studies determine that Tenant is in violation of this Section 7.02, then Tenant shall reimburse Landlord for the costs of such tests and studies. To the extent permitted by Law,
Tenant hereby indemnifies, and agrees to protect, defend and hold the Indemnitees harmless, against any and all actions, claims, demands, liability, costs and expenses, including attorneys’ fees and expenses for the defense thereof, arising out
of any and all of (i) the introduction, use, discharge or release of any Hazardous Material into, in or about the Project by Tenant or any Tenant Parties, including any injury to or death of persons or damage to or destruction of property
resulting therefrom, and (ii) any failure of Tenant or any Tenant Parties to observe the covenants of this Section 7.02. In case of any action or proceeding brought against the Indemnitees by reason of any such claim, upon notice from
Landlord, Tenant covenants to defend such action or proceeding by counsel chosen by Tenant and reasonably approved by Landlord. Landlord or Tenant may settle, compromise or dispose of any and all actions, claims and demands related to the foregoing
indemnity, subject 

  
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to the prior written approval of the other, which approval shall not be unreasonably withheld. If any Hazardous Material is released, discharged or disposed of on or about the Property and such
release, discharge or disposal is not caused by Tenant or any Tenant Parties, such release, discharge or disposal shall be deemed casualty damage under Article Fourteen to the extent that the Premises are affected thereby; in such case, Landlord and
Tenant shall have the obligations and rights respecting such casualty damage provided under such Article. 
 (d)    The
right to use and store in, and transport to and from, the Premises the Permitted Hazardous Material is personal to ARMO Biosciences, Inc. and may not be assigned or otherwise transferred by ARMO Biosciences, Inc. without the prior written consent of
Landlord, which consent may be withheld in Landlord’s sole discretion, except (i) to a Permitted Transferee which is an assignee of the Lease and which has satisfied the requirements of Sections 10.01 and 10.05 of this Lease: and
(ii) ARMO Biosciences, Inc. may permit a Permitted Transferee which is a sublessee to use and store in, and transport to and from, the Premises the Permitted Hazardous Material to the same extent as ARMO Biosciences, Inc. has such right under
this Lease, but use by all such sublessees and ARMO Biosciences, Inc. shall not in the aggregate exceed the maximum quantities of Permitted Hazardous Material and shall be subject to all the provisions of this Lease. Any consent by Landlord pursuant
to Article Ten to an assignment, transfer, subletting, mortgage, pledge, hypothecation or encumbrance of this Lease, and any interest therein or right or privilege appurtenant thereto, shall not constitute consent by Landlord to the use or storage
at, or transportation to, the Premises of any Hazardous Material (including a Permitted Hazardous Material) by any such assignee, sublessee or transferee unless Landlord expressly agrees otherwise in writing. Notwithstanding any of the foregoing to
the contrary, with respect to any request for assignment or sublease which further specifies that Tenant requests approval for the transfer to the assignee or sublessee of the right to use and store in, and transport to and from, the Premises,
Permitted Hazardous Material as set forth in this Lease, provided that the assignee or sublessee has a net worth of at least Twelve Million Dollars ($12,000,000), excluding any value attributable to goodwill or going concern value, then Landlord
shall not unreasonably withhold consent to the transfer of such right to the assignee or sublessee. Any consent by Landlord to the use or storage at, or transportation to or from the Premises, of any Hazardous Material (including a Permitted
Hazardous Material) by an assignee, sublessee or transferee of Tenant shall not constitute a waiver of Landlord’s right to refuse such consent as to any subsequent assignee or transferee. 

(e)    Tenant acknowledges that the sewer piping at the Project is made of ABS plastic. Accordingly, without
Landlord’s prior written consent, which may be given or withheld in Landlord’s sole discretion, only ordinary domestic sewage is permitted to be put into the drains at the Premises. UNDER NO CIRCUMSTANCES SHALL Tenant EVER DEPOSIT ANY
ESTERS OR KETONES (USUALLY FOUND IN SOLVENTS TO CLEAN UP PETROLEUM PRODUCTS) IN THE DRAINS AT THE PREMISES. If Tenant desires to put any substances other than ordinary domestic sewage into the drains, it shall first submit to Landlord a complete
description of each such substance, including its chemical composition, and a sample of such substance suitable for laboratory testing. Landlord shall promptly determine whether or not the substance can be deposited into the drains and its
determination shall be absolutely binding on Tenant. Upon demand, Tenant shall reimburse Landlord for expenses incurred by Landlord in making such determination. If any substances not so approved hereunder are deposited in the drains in
Tenant’s Premises, Tenant shall be liable to Landlord for all damages resulting therefrom, including but not limited to all costs and expenses incurred by Landlord in repairing or replacing the piping so damaged. 

(f)    Upon any violation of any of the foregoing covenants, in addition to all remedies available to a landlord against
the defaulting tenant, including but not limited to those set forth in Article Eleven of this Lease, Tenant expressly agrees that upon any such violation Landlord may, at its option (i) immediately terminate this Lease by giving written notice
to Tenant of such termination, or (ii) continue this Lease in effect until compliance by Tenant with its clean-up and removal covenant (notwithstanding the expiration of the Term). No action by Landlord
hereunder shall impair the obligations of Tenant pursuant to this Section 7.02. 
 7.03    LANDLORD ACCESS TO PREMISES; APPROVALS

 (a)    Tenant shall permit Landlord to erect, use and maintain pipes, ducts, wiring and conduits in and through the
Premises, so long as Tenant’s use, layout or design of the Premises is not materially affected or altered. Landlord or Landlord’s agents shall have the right to enter upon the Premises in the event of an emergency, or to inspect the
Premises, to perform janitorial and other services (if any), to conduct safety and other testing in the Premises and to make such repairs, alterations, improvements or additions to the Premises or the Building or other parts of the Property as
Landlord may deem necessary or desirable (including all alterations, improvements and additions in connection with a change in service provider or providers). Janitorial and cleaning services (if any) shall be performed after normal business hours.
Any entry or work by Landlord may be during normal business hours and Landlord may use reasonable efforts to ensure that any entry or work shall not materially interfere with Tenant’s occupancy of the Premises. 

  
 15 

 (b)    Advance notice shall not be required for entry to perform routine
janitorial and cleaning services or for entry in the event of an emergency or urgent situation, as reasonably determined by Landlord, but any other entry or work by Landlord shall be upon at least twenty-four (24) hours prior written notice to
Tenant, which written notice may include notices e-mailed to Tenant’s on-site manager at the Premises. If Tenant shall not be personally present to permit an entry
into the Premises when for any reason an entry therein shall be necessary or permissible, Landlord (or Landlord’s agents), after attempting to notify Tenant (unless Landlord believes an emergency situation exists) as set forth in this
Paragraph, may enter the Premises without rendering Landlord or its agents liable therefor, and without relieving Tenant of any obligations under this Lease. 

(c)    Landlord may enter the Premises for the purpose of conducting such inspections, tests and studies as Landlord may
deem desirable or necessary to confirm Tenant’s compliance with all Laws and Environmental Laws or for other purposes necessary in Landlord’s reasonable judgment to ensure the sound condition of the Property and the systems serving the
Property. Landlord’s rights under this Section 7.03 (c) are for Landlord’s own protection only, and Landlord has not, and shall not be deemed to have assumed, any responsibility to Tenant or any other party as a result of the exercise
or non-exercise of such rights, for compliance with Laws or Environmental Laws or for the accuracy or sufficiency of any item or the quality or suitability of any item for its intended use. 

(d)    Landlord may do any of the foregoing, or undertake any of the inspection or work described in the preceding
paragraphs without such action constituting an actual or constructive eviction of Tenant, in whole or in part, or giving rise to an abatement of Rent by reason of loss or interruption of business of the Tenant, or otherwise. 

(e)    The review, approval or consent of Landlord with respect to any item required or permitted under this Lease is for
Landlord’s own protection only, and Landlord has not, and shall not be deemed to have assumed, any responsibility to Tenant or any other party, as a result of the exercise or non-exercise of such rights,
for compliance with Laws or Environmental Laws or for the accuracy or sufficiency of any item or the quality or suitability of any item for its intended use. 

7.04    QUIET ENJOYMENT 
 Landlord covenants,
in lieu of any implied covenant of quiet possession or quiet enjoyment, that so long as Tenant is in compliance with the covenants and conditions set forth in this Lease, Tenant shall have the right to quiet enjoyment of the Premises without
hindrance or interference from Landlord or those claiming through Landlord, and subject to the covenants and conditions set forth in the Lease and to the rights of any Mortgagee or ground lessor. 

ARTICLE EIGHT 
 MAINTENANCE 

8.01    LANDLORD’S MAINTENANCE 
 Subject
to Article Fourteen and Section 8.02, Landlord shall maintain the structural portions of the Building, the roof, exterior walls and exterior doors, foundation, and underslab standard sewer system of the Building in good, clean and safe
condition, and shall use reasonable efforts, through Landlord’s program of regularly scheduled preventive maintenance, to keep the Building’s standard heating, ventilation and air conditioning (“HVAC”) equipment in reasonably
good order and condition. Notwithstanding the foregoing, Landlord shall have no responsibility to repair the Building’s standard heating, ventilation and air conditioning equipment exclusively serving the Premises, and all such repairs shall be
performed by Tenant pursuant to the terms of Section 8.02. Landlord shall also (a) maintain the landscaping, parking facilities and other Common Areas of the Project, and (b) wash the outside of exterior windows at intervals
determined by Landlord. Except as provided in Article Fourteen and Article Fifteen, there shall be no abatement of rent, no allowance to Tenant for diminution of rental value and no liability of Landlord by reason of inconvenience, annoyance or any
injury to or interference with Tenant’s business arising from the making of or the failure to make any repairs, alterations or improvements in or to any portion of the Project or in or to any fixtures, appurtenances or equipment therein. Tenant
waives the right to make repairs at Landlord’s expense under any law, statute or ordinance now or hereafter in effect. 

8.02    TENANT’S MAINTENANCE 
 Subject
to the provisions of Article Fourteen, Tenant shall, at Tenant’s sole cost and expense, make all repairs to the Premises and fixtures therein which Landlord is not required to make pursuant to Section 8.01, including repairs to the
interior walls, ceilings and windows of the Premises, the interior doors, Tenant’s signage, and the electrical, life-safety, plumbing and heating, ventilation and air conditioning systems located within or exclusively serving the Premises and
shall maintain the Premises, the fixtures and utilities systems therein, and the area immediately 

  
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surrounding the Premises (including all garbage enclosures), in a good, clean and safe condition. Tenant shall deliver to Landlord a copy of any maintenance contract entered into by Tenant with
respect to the Premises. Tenant shall also, at Tenant’s expense, keep any non-standard heating, ventilating and air conditioning equipment and other non-standard
equipment in the Building in good condition and repair, using contractors approved in advance, in writing, by Landlord. Notwithstanding Section 8.01 above, but subject to the waivers set forth in Section 16.04. Tenant will pay for any
repairs to the Building or the Project which are caused by any negligence or carelessness, or by any willful and wrongful act, of Tenant or its assignees, subtenants or employees, or of the respective agents of any of the foregoing persons, or of
any other persons permitted in the Building or elsewhere in the Project by Tenant or any of them. Tenant will maintain the Premises, and will leave the Premises upon termination of this Lease, in a safe, clean, neat and sanitary condition. 

ARTICLE NINE 
 ALTERATIONS AND
IMPROVEMENTS 
 9.01    TENANT ALTERATIONS 

(a)    The following provisions shall apply to the completion of any Tenant Alterations: 

(1)    Tenant shall not, except as provided herein, without the prior written consent of Landlord, which
consent shall not be unreasonably withheld, make or cause to be made any Tenant Alterations in or to the Premises or any Property systems serving the Premises. Prior to making any Tenant Alterations, Tenant shall give Landlord ten (10) days
prior written notice (or such earlier notice as would be necessary pursuant to applicable Law) to permit Landlord sufficient time to post appropriate notices of non-responsibility. Subject to all other
requirements of this Article Nine, Tenant may undertake Decoration work without Landlord’s prior written consent. Tenant shall furnish Landlord with the names and addresses of all contractors and subcontractors and copies of all contracts. All
Tenant Alterations shall be completed at such time and in such manner as Landlord may from time to time designate, and only by contractors or mechanics approved by Landlord, which approval shall not be unreasonably withheld, provided, however, that
Landlord may, in its sole discretion, specify the engineers and contractors to perform all work relating to the Building’s systems (including the mechanical, heating, plumbing, security, ventilating,
air-conditioning, electrical, communication and the fire and life safety systems in the Building). The contractors, mechanics and engineers who may be used are further limited to those whose work will not
cause or threaten to cause disharmony or interference with Landlord or other tenants in the Building and their respective agents and contractors performing work in or about the Building. Landlord may further condition its consent upon Tenant
furnishing to Landlord and Landlord approving prior to the commencement of any work or delivery of materials to the Premises related to the Tenant Alterations such of the following as specified by Landlord: architectural plans and specifications,
opinions from Landlord’s engineers stating that the Tenant Alterations will not in any way adversely affect the Building’s systems, necessary permits and licenses, certificates of insurance, and such other documents in such form reasonably
requested by Landlord. Landlord may, in the exercise of reasonable judgment, request that Tenant provide Landlord with appropriate evidence of Tenant’s ability to complete and pay for the completion of the Tenant Alterations such as a
performance bond or letter of credit. Upon completion of the Tenant Alterations, Tenant shall deliver to Landlord an as-built mylar and digitized (if available) set of plans and specifications for the Tenant
Alterations. 
 (2)    Tenant shall pay the cost of all Tenant Alterations and the cost of decorating the
Premises and any work to the Property occasioned thereby. In connection with completion of any Tenant Alterations, Tenant shall pay Landlord a construction fee and all elevator and hoisting charges at Landlord’s then standard rate (which fees
and charges shall not to exceed three percent (3%) of the cost of the Tenant Alterations). Upon completion of Tenant Alterations, Tenant shall furnish Landlord with contractors’ affidavits and full and final waivers of lien and receipted bills
covering all labor and materials expended and used in connection therewith and such other documentation reasonably requested by Landlord or Mortgagee. 

(3)    Tenant agrees to complete all Tenant Alterations (i) in accordance with all Laws, Environmental
Laws, all requirements of applicable insurance companies and in accordance with Landlord’s standard construction rules and regulations, and (ii) in a good and workmanlike manner with the use of good grades of materials. Tenant shall notify
Landlord immediately if Tenant receives any notice of violation of any Law in connection with completion of any Tenant Alterations and shall immediately take such steps as are necessary to remedy such violation. In no event shall such supervision or
right to supervise by Landlord nor shall any approvals given by Landlord under this Lease constitute any warranty by Landlord to Tenant of the adequacy of the design, workmanship or quality of such work or materials for Tenant’s intended use or
of compliance with the requirements of Section 9.01(a)(3)(i) and (ii) above or impose any liability upon Landlord in connection with the performance of such work. 

  
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 (b)    All Tenant Additions to the Premises whether installed by Landlord or
Tenant, shall without compensation or credit to Tenant, become part of the Premises and the property of Landlord at the time of their installation and shall remain in the Premises, unless pursuant to Article Twelve, Tenant may remove them or is
required to remove them at Landlord’s request. 
 9.02    LIENS 

Tenant shall not permit any lien or claim for lien of any mechanic, laborer or supplier or any other lien to be filed against the Building, the Land, the
Premises, or any other part of the Property arising out of work performed, or alleged to have been performed by, or at the direction of, or on behalf of Tenant. If any such lien or claim for lien is filed, Tenant shall within ten (10) days of
receiving notice of such lien or claim (a) have such lien or claim for lien released of record or (b) deliver to Landlord a bond in form, content, amount, and issued by surety, satisfactory to Landlord, indemnifying, protecting, defending
and holding harmless the Indemnitees against all costs and liabilities resulting from such lien or claim for lien and the foreclosure or attempted foreclosure thereof. If Tenant fails to take any of the above actions, Landlord, in addition to its
rights and remedies under Article Eleven, without investigating the validity of such lien or claim for lien, may pay or discharge the same and Tenant shall, as payment of additional Rent hereunder, reimburse Landlord upon demand for the amount so
paid by Landlord, including Landlord’s expenses and attorneys’ fees. 
 ARTICLE TEN 

ASSIGNMENT AND SUBLETTING 

10.01    ASSIGNMENT AND SUBLETTING 

(a)    Without the prior written consent of Landlord, which may be withheld in Landlord’s sole discretion, Tenant may
not sublease, assign, mortgage, pledge, hypothecate or otherwise transfer or permit the transfer of this Lease or the encumbering of Tenant’s interest therein in whole or in part, by operation of Law or otherwise or permit the use or occupancy
of the Premises, or any part thereof, by anyone other than Tenant, provided, however, if Landlord chooses not to recapture the space proposed to be subleased or assigned as provided in Section 10.02, Landlord shall not unreasonably withhold its
consent to a subletting or assignment under this Section 10.01. Tenant agrees that the provisions governing sublease and assignment set forth in this Article Ten shall be deemed to be reasonable. If Tenant desires to enter into any sublease of
the Premises or assignment of this Lease, Tenant shall deliver written notice thereof to Landlord (“Tenant’s Notice”), together with the identity of the proposed subtenant or assignee and the proposed principal terms thereof and
financial and other information sufficient for Landlord to make an informed judgment with respect to such proposed subtenant or assignee at least forty-five (45) days prior to the commencement date of the term of the proposed sublease or
assignment. If Tenant proposes to sublease less than all of the Rentable Area of the Premises, the space proposed to be sublet and the space retained by Tenant must each be a marketable unit as reasonably determined by Landlord and otherwise in
compliance with all Laws. Landlord shall notify Tenant in writing of its approval or disapproval of the proposed sublease or assignment or its decision to exercise its rights under Section 10.02 within thirty (30) days after receipt of
Tenant’s Notice (and all required information). In no event may Tenant sublease any portion of the Premises or assign the Lease to any other tenant of the Project unless Landlord does not or will not have space available at a similar time to
when the space subject to the proposed assignment or sublease is to be available to the assignee or subtenant, for a similar size and term as the proposed assignment or sublease transaction. Tenant shall submit for Landlords approval (which approval
shall not be unreasonably withheld) any advertising which Tenant or its agents intend to use with respect to the space proposed to be sublet. 

(b)    With respect to Landlord’s consent to an assignment or sublease, Landlord may take into consideration any
factors which Landlord may deem relevant, and the reasons for which Landlord’s denial shall be deemed to be reasonable shall include, without limitation, the following: 

(i)    the business reputation or creditworthiness of any proposed subtenant or assignee is not acceptable
to Landlord; or 
 (ii)    in Landlord’s reasonable judgment the proposed assignee or subtenant
would diminish the value or reputation of the Building or Landlord; or 

  
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 (iii)    any proposed assignee’s or subtenant’s use
of the Premises would violate Section 7.01 of the Lease or would violate the provisions of any other leases of tenants in the Project: 

(iv)    the proposed assignee or subtenant is either a governmental agency, a school or similar operation,
or a medical related practice; or 
 (v)    the proposed subtenant or assignee is a bona fide prospective
tenant of Landlord in the Project as demonstrated by a written proposal dated within ninety (90) days prior to the date of Tenant’s request; or 

(vi)    the proposed subtenant or assignee would materially increase the estimated pedestrian and vehicular
traffic to and from the Premises and the Building. 
 In no event shall Landlord be obligated to consider a consent to any proposed assignment of the Lease
which would assign less than the entire Premises. In the event Landlord wrongfully withholds its consent to any proposed sublease of the Premises or assignment of the Lease, Tenant’s sole and exclusive remedy therefor shall be to seek specific
performance of Landlord’s obligations to consent to such sublease or assignment (and/or damages, but only upon a final, non-appealable judicial determination that Landlord has wrongfully withheld its
consent to such sublease or assignment). 
 (c)    Any sublease or assignment shall be expressly subject to the terms
and conditions of this Lease. Any subtenant or assignee shall execute such documents as Landlord may reasonably require to evidence the terms of Landlord’s consent to the sublease or assignment, including agreement to the effect set forth in
Sections 10.01 and 10.05 of this Lease. Tenant shall deliver to Landlord a copy of all agreements executed by Tenant and the proposed subtenant and assignee with respect to the Premises. Landlord’s approval of a sublease, assignment,
hypothecation, transfer or third party use or occupancy shall not constitute a waiver of Tenant’s obligation to obtain Landlord’s consent to further assignments or subleases, hypothecations, transfers or third party use or occupancy. 

(d)    For purposes of this Article Ten, an assignment shall be deemed to include a change in the majority control of
Tenant, resulting from any transfer, sale or assignment of shares of stock of Tenant occurring by operation of Law or otherwise, and includes any merger, acquisition, consolidation or reorganization. Notwithstanding any provision of this Section to
the contrary, an assignment for purposes of this Article does not include any transfer of control of the stock or membership interests of Tenant through (i) any public offering of shares of stock in Tenant in accordance with applicable State
and Federal law, rules, regulations and orders if thereafter the stock shall be listed and publicly traded through the New York Stock Exchange or the NASDAQ national market; or (ii) public sale of such stock effected through such exchange or
the NASDAQ national market. If Tenant is a partnership, any change in the partners of Tenant shall be deemed to be an assignment. 

(e)    Tenant may assign this Lease to a successor to Tenant by purchase, merger, consolidation or non-bankruptcy reorganization (an “Ownership Change”) or assign this Lease or sublet all or a portion of the Premises to an Affiliate without the consent of Landlord, provided that all of the following
conditions are satisfied (a “Permitted Transfer”, and such permitted assignee or subtenant is a “Permitted Transferee): (1) Tenant is not in Default: (2) in the event of an Ownership Change, Tenant’s successor shall have a
net worth of at least Twelve Million Dollars ($12,000,000), or in the event of a Transfer to an Affiliate, Tenant continues to have a net worth of at least Twelve Million Dollars ($12,000,000), or the Affiliate has a net worth of at least Twelve
Million Dollars ($12,000,000): (3) Tenant shall give Landlord written notice at least fifteen (15) business days prior to the effective date of the Permitted Transfer (unless prohibited by law or a
non-disclosure agreement, in which case Tenant shall give such notice within three (3) business days after the effective date of the Permitted Transfer); and (4) if requested by Landlord, Tenant and
Tenant’s successor shall sign a form of agreement setting forth representations as to the type of Ownership Change and as to the facts that satisfy each of conditions (1) and (2) above, and assumption of all obligations of the Tenant under
the Lease. Tenant’s notice to Landlord shall include information and documentation evidencing the Permitted Transfer and showing that each of the above conditions has been satisfied. All determinations of net worth under this Lease shall
exclude any value attributable to goodwill or going concern value and otherwise be based on generally accepted accounting principles. To the extent that such representations, information and documentation include Confidential Information (as defined
below), Landlord agrees not to use any Confidential Information for any purpose except to evaluate and engage in discussions with respect to the assignment or sublease, and in connection with the ongoing lease relationship. Landlord agrees that it
shall take reasonable measures to protect the secrecy of and avoid disclosure and unauthorized use of the Confidential Information. Landlord agrees not to disclose any Confidential Information to third parties or to employees of Landlord, except:
(i) to those employees who reasonably need the information for the purposes described above and (ii) to Landlord’s affiliates, partners, members, co-owners, brokers, property managers,
consultants, attorneys, accountants, auditors, rating agencies, regulators, lenders and 

  
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buyers (collectively, “Related Parties”), for the purpose of performing their respective professional responsibilities. Landlord shall have the right to make copies of Confidential
Information, but such copies shall be subject to the same obligations hereunder as the originals. In the event that Landlord is requested or becomes legally compelled (to comply with legal, regulatory or similar requirements, or court order) to make
any disclosure which would otherwise be prohibited by this Section, Landlord may do so and Landlord, will, if lawfully permitted to do so, and at no cost, take reasonable measures, to provide Tenant with prompt notice of such request(s) so that
Tenant may seek an appropriate protective order or other appropriate remedy and/or waive compliance with the provisions of this Section. Landlord’s obligations under this Section shall terminate four months after receipt of the Confidential
Information. “Confidential Information” shall mean such written financial information disclosed to Landlord by Tenant that is in fact confidential and that Tenant identifies as confidential by written notice to Landlord at the time of
delivery, and such obligation shall terminate the earlier of four months after receipt or if and when the information ceases to be confidential through no fault of Landlord. 

(f)    With respect to any sublease, including any to a Permitted Transferee, Tenant hereby irrevocably assigns to
Landlord, effective upon any such sublease, all rent and other payments due from subtenant under the sublease, provided however, that Tenant shall have a license to collect such rent and other payments until the occurrence of a default by Tenant
under any of the provisions of the Lease, and notice to Tenant of such default shall not be a prerequisite to Landlord’s right to collect subrent. At any time at Landlord’s option, Landlord shall have the right to give notice to the
subtenant of such assignment. Landlord shall credit Tenant with any rent received by Landlord under such assignment but the acceptance of any payment on account of rent from the subtenant as the result of any such default shall in no manner
whatsoever serve to release Tenant from any liability under the terms, covenants, conditions, provisions or agreement under the Lease. No such payment of rent or any other payment by the subtenant directly to Landlord and/or acceptance of such
payment(s) by Landlord, regardless of the circumstances or reasons therefor, shall in any manner whatsoever be deemed an attornment by the subtenant to Landlord in the absence of a specific written agreement signed by Landlord to such an effect. For
purposes of this Section, any use or occupancy by a Permitted Transferee (unless it is an assignee) without a formal sublease shall for the purposes of this Section be deemed to be a sublease at the same rental rate as provided in the Lease. 

10.02    RECAPTURE 
 Except with respect to
an assignment or sublease to a Permitted Transferee in accordance with the provisions of Section 10.01, Landlord shall have the option to exclude from the Premises covered by this Lease (“recapture), the space proposed to be sublet or
subject to the assignment, effective as of the proposed commencement date of such sublease or assignment. If Landlord elects to recapture, Tenant shall surrender possession of the space proposed to be subleased or subject to the assignment to
Landlord on the effective date of recapture of such space from the Premises, such date being the Termination Date for such space. Effective as of the date of recapture of any portion of the Premises pursuant to this section, the Monthly Base Rent,
Rentable Area of the Premises and Tenant’s Share shall be adjusted accordingly. 
 10.03    EXCESS RENT 

Tenant shall pay Landlord on the first day of each month during the term of the sublease or assignment, fifty percent (50%) of the amount by which the sum of
all rent and other consideration (direct or indirect) due from the subtenant or assignee for such month exceeds: (i) that portion of the Monthly Base Rent and Rent Adjustments due under this Lease for said month which is allocable to the space
sublet or assigned; and (ii) the following costs and expenses for the subletting or assignment of such space: (1) brokerage commissions and attorneys’ fees and expenses, (2) the actual costs paid in making any improvements or
substitutions in the Premises required by any sublease or assignment: and (3) “free rent” periods, costs of any inducements or concessions given to subtenant or assignee, moving costs, and other amounts in respect of such subtenant’s
or assignee’s other leases or occupancy arrangements. All such costs and expenses shall be amortized over the term of the sublease or assignment pursuant to sound accounting principles. 

10.04    TENANT LIABILITY 
 In the event of
any sublease or assignment, whether or not with Landlord’s consent, Tenant shall not be released or discharged from any liability, whether past, present or future, under this Lease, including any liability arising from the exercise of any
renewal or expansion option, to the extent such exercise is expressly permitted by Landlord. Tenant’s liability shall remain primary, and in the event of default by any subtenant, assignee or successor of Tenant in performance or observance of
any of the covenants or conditions of this Lease, Landlord may proceed directly against Tenant without the necessity of exhausting remedies against said subtenant, assignee or successor. After any assignment, Landlord may consent to subsequent
assignments or subletting of this Lease, or amendments or 

  
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modifications of this Lease with assignees of Tenant, without notifying Tenant, or any successor of Tenant, and without obtaining its or their consent thereto, and such action shall not relieve
Tenant or any successor of Tenant of liability under this Lease. If Landlord grants consent to such sublease or assignment, Tenant shall pay all reasonable attorneys’ fees and expenses incurred by Landlord with respect to such assignment or
sublease. In addition, if Tenant has any options to extend the Term of this Lease or to add other space to the Premises, such options shall not be available to any subtenant or assignee (except for a Permitted Transferee which is an assignee of the
Lease and which has satisfied the requirements of Sections 10.01 and 10.05 of this Lease), directly or indirectly without Landlord’s express written consent, which may be withheld in Landlord’s sole discretion. 

10.05    ASSUMPTION AND ATTORNMENT 
 If
Tenant shall assign this Lease as permitted herein, the assignee shall expressly assume all of the obligations of Tenant hereunder in a written instrument satisfactory to Landlord and furnish it to Landlord not later than fifteen (15) days
prior to the effective date of the assignment. If Tenant shall sublease the Premises as permitted herein, Tenant shall, at Landlord’s option, within fifteen (15) days following any request by Landlord, obtain and furnish to Landlord a
written agreement satisfactory to Landlord to the effect that (a) the subtenant will attorn to Landlord and will pay all subrent directly to Landlord in the event of any termination of this Lease for any reason, including rejection or deemed
rejection in any bankruptcy proceeding, and (b) that in the event of any default by Tenant under this Lease, subtenant will pay all subrent directly to Landlord. 

ARTICLE ELEVEN 
 DEFAULT AND
REMEDIES 
 11.01    EVENTS OF DEFAULT. 

The occurrence or existence of any one or more of the following shall constitute a “Default” by Tenant under this Lease: 

(i)    Tenant fails to pay any installment or other payment of Rent including Rent Adjustment Deposits or
Rent Adjustments within five (5) days after written notice to Tenant of such failure to pay, provided however, after the first time that Tenant fails to pay the applicable delinquency within such five (5) day cure period, written notice
shall no longer be required and failure to pay any installment or other payment of Rent including Rent Adjustment Deposits or Rent Adjustments within five (5) days after the date when due shall constitute a Default; 

(ii)    Tenant fails to observe or perform any of the other covenants, conditions or provisions of this
Lease or the Workletter and, unless the default involves a hazardous condition, which shall be cured forthwith, or unless the failure to perform is a Default for which this Lease specifies there is no cure or grace period or specifies there is no
additional cure or grace period, fails to cure such default within fifteen (15) days after written notice thereof to Tenant, provided that, if Tenant has exercised reasonable diligence to cure such failure and such failure cannot reasonably be
cured within such fifteen (15) day period, then such cure period shall be extended, but not in excess of an additional sixty (60) days, so long as Tenant diligently and continuously prosecutes the cure to completion: 

(iii)    the interest of Tenant in this Lease is levied upon under execution or other legal process; 

(iv)    a petition is filed by or against Tenant to declare Tenant bankrupt or seeking a plan of
reorganization or arrangement under any Chapter of the Bankruptcy Act, or any amendment, replacement or substitution therefor, or to delay payment of, reduce or modify Tenant’s debts, which in the case of an involuntary action is not discharged
within thirty (30) days; 
 (v)    Tenant is declared insolvent by Law or any assignment of
Tenant’s property is made for the benefit of creditors; 
 (vi)    a receiver is appointed for
Tenant or Tenant’s property, which appointment is not discharged within thirty (30) days: 

(vii)    any action taken by or against Tenant to reorganize or modify Tenant’s capital structure in a
materially adverse way which in the case of an involuntary action is not discharged within thirty (30) days: 

(viii)    upon the dissolution of Tenant; or 

  
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 (ix)    upon the third occurrence within any Lease Year that
Tenant fails to pay Rent when due or has breached a particular covenant of this Lease (whether or not such failure or breach is thereafter cured within any stated cure or grace period or statutory period). 

11.02    LANDLORD’S REMEDIES 

(a)    A Default shall constitute a breach of the Lease for which Landlord shall have the rights and remedies set forth in
this Section 11.02 and all other rights and remedies set forth in this Lease or now or hereafter allowed by Law, whether legal or equitable, and all rights and remedies of Landlord shall be cumulative and none shall exclude any other right or
remedy. 
 (b)    With respect to a Default, at any time Landlord may terminate Tenant’s right to possession by
written notice to Tenant stating such election. Upon the termination of Tenant’s right to possession pursuant to this Section 11.02, Tenant’s right to possession shall terminate and this Lease shall terminate, and Tenant shall remain
liable as hereinafter provided. Upon such termination, Landlord shall have the right, subject to applicable Law, to re-enter the Premises and dispossess Tenant and the legal representatives of Tenant and all
other occupants of the Premises by unlawful detainer or other summary proceedings, or otherwise as permitted by Law, regain possession of the Premises and remove their property (including their trade fixtures, personal property and those Tenant
Additions which Tenant is required or permitted to remove under Article Twelve), but Landlord shall not be obligated to effect such removal, and such property may, at Landlord’s option, be stored elsewhere, sold or otherwise dealt with as
permitted by Law, at the risk of, expense of and for the account of Tenant, and the proceeds of any sale shall be applied pursuant to Law. Landlord shall in no event be responsible for the value, preservation or safekeeping of any such property.
Tenant hereby waives all claims for damages that may be caused by Landlord’s removing or storing Tenant’s personal property pursuant to this Section or Section 12.01, and Tenant hereby indemnifies, and agrees to defend, protect and
hold harmless, the Indemnitees from any and all loss, claims, demands, actions, expenses, liability and cost (including attorneys’ fees and expenses) arising out of or in any way related to such removal or storage. Upon such written termination
of Tenant’s right to possession and this Lease, Landlord shall have the right to recover damages for Tenant’s Default as provided herein or by Law, including the following damages provided by California Civil Code Section 1951.2: 

(1)    the worth at the time of award of the unpaid Rent which had been earned at the time of termination;

 (2)    the worth at the time of award of the amount by which the unpaid Rent which would have been
earned after termination until the time of award exceeds the amount of such Rent loss that Tenant proves could reasonably have been avoided; 

(3)    the worth at the time of award of the amount by which the unpaid Rent for the balance of the term of
this Lease after the time of award exceeds the amount of such Rent loss that Tenant proves could be reasonably avoided; and 

(4)    any other amount necessary to compensate Landlord for all the detriment proximately caused by
Tenant’s failure to perform its obligations under this Lease or which in the ordinary course of things would be likely to result therefrom. The word “rent” as used in this Section 11.02 shall have the same meaning as the defined
term Rent in this Lease. The “worth at the time of award” of the amount referred to in clauses (1) and (2) above is computed by allowing interest at the Default Rate. The worth at the time of award of the amount referred to in clause
(3) above is computed by discounting such amount at the discount rate of the Federal Reserve Bank of San Francisco at the time of award plus one percent (1%). For the purpose of determining unpaid Rent under clause (3) above, the monthly
Rent reserved in this Lease shall be deemed to be the sum of the Monthly Base Rent, and monthly Storage Space Rent, if any, and the amounts last payable by Tenant as Rent Adjustments for the calendar year in which Landlord terminated this Lease as
provided hereinabove. 
 (c)    Even if Tenant is in Default and/or has abandoned the Premises, this Lease shall
continue in effect for so long as Landlord does not terminate Tenant’s right to possession by written notice as provided in Section 11.02(b) above, and Landlord may enforce all its rights and remedies under this Lease, including the right
to recover Rent as it becomes due under this Lease. In such event, Landlord shall have all of the rights and remedies of a landlord under California Civil Code Section 1951.4 (lessor may continue Lease in effect after Tenant’s Default and
abandonment and recover Rent as it becomes due, if Tenant has the right to sublet or assign, subject only to 

  
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reasonable limitations), or any successor statute. During such time as Tenant is in Default, if Landlord has not terminated this Lease by written notice and if Tenant requests Landlord’s
consent to an assignment of this Lease or a sublease of the Premises, subject to Landlord’s option to recapture pursuant to Section 10.02, Landlord shall not unreasonably withhold its consent to such assignment or sublease. Tenant
acknowledges and agrees that the provisions of Article Ten shall be deemed to constitute reasonable limitations of Tenant’s right to assign or sublet. Tenant acknowledges and agrees that in the absence of written notice pursuant to
Section 11.02(b) above terminating Tenant’s right to possession, no other act of Landlord shall constitute a termination of Tenant’s right to possession or an acceptance of Tenant’s surrender of the Premises, including acts of
maintenance or preservation or efforts to relet the Premises or the appointment of a receiver upon initiative of Landlord to protect Landlord’s interest under this Lease or the withholding of consent to a subletting or assignment, or
terminating a subletting or assignment, if in accordance with other provisions of this Lease. 
 (d)    In the event
that Landlord seeks an injunction with respect to a breach or threatened breach by Tenant of any of the covenants, conditions or provisions of this Lease, Tenant agrees to pay the premium for any bond required in connection with such injunction.

 (e)    Tenant hereby waives any and all rights to relief from forfeiture, redemption or reinstatement granted by Law
(including California Civil Code of Procedure Sections 1174 and 1179) in the event of Tenant being evicted or dispossessed for any cause or in the event of Landlord obtaining possession of the Premises by reason of Tenant’s Default or
otherwise: 
 (f)    When this Lease requires giving or service of a notice of Default or of a failure of Tenant to
observe or perform any covenant, condition or provision of this Lease which will constitute a Default unless Tenant so observes or performs within any applicable cure period, and so long as the notice given or served provides Tenant the longer of
any applicable cure period required by this Lease or by statute, then the giving of any equivalent or similar statutory notice, including any equivalent or similar notices required by California Code of Civil Procedure Section 1161 or any
similar or successor statute, shall replace and suffice as any notice required under this Lease. When a statute requires service of a notice in a particular manner, service of that notice (or a similar notice required by this Lease) pursuant to the
statutory service of notice procedures shall be sufficient in lieu of, and shall satisfy, any requirements to give notice to the addresses and in the manner required by Article Twenty-four, and without limiting the foregoing, any notice of unlawful
detainer required by California Code of Civil Procedure Section 1161 or any similar or successor statute with respect to termination of possession, recovery of possession, eviction, termination of the Lease or similar action or proceeding shall
not be required to be given pursuant to Article Twenty-four or to the notice addresses for Tenant set forth in this Lease, but instead may be served as required by Code of Civil Procedure Section 1162 or any similar or successor statute, and
for purposes of Code of Civil Procedure Section 1162 or any similar or successor statute, Tenant’s “place of residence” and “usual place of business” shall mean the address of the Premises. 

(g)    The voluntary or other surrender or termination of this Lease, or a mutual termination or cancellation thereof,
shall not work a merger and shall terminate all or any existing assignments, subleases, subtenancies or occupancies permitted by Tenant, except if and as otherwise specified in writing by Landlord. 

(h)    No delay or omission in the exercise of any right or remedy of Landlord upon any default by Tenant, and no exercise
by Landlord of its rights pursuant to Section 26.15 to perform any duty which Tenant fails timely to perform, shall impair any right or remedy or be construed as a waiver. No provision of this Lease shall be deemed waived by Landlord unless
such waiver is in a writing signed by Landlord. The waiver by Landlord of any breach of any provision of this Lease shall not be deemed a waiver of any subsequent breach of the same or any other provision of this Lease. 

11.03    ATTORNEY’S FEES 
 In the event
any party brings any suit or other proceeding with respect to the subject matter or enforcement of this Lease, the prevailing party (as determined by the court, agency or other authority before which such suit or proceeding is commenced) shall, in
addition to such other relief as may be awarded, be entitled to recover attorneys’ fees, expenses and costs of investigation as actually incurred, including court costs, expert witness fees, costs and expenses of investigation, and all
attorneys’ fees, costs and expenses in any such suit or proceeding (including in any action or participation in or in connection with any case or proceeding under the Bankruptcy Code, 11 United States Code Sections 101 et seq., or any successor
statutes, in establishing or enforcing the right to indemnification, in appellate proceedings, or in connection with the enforcement or collection of any judgment obtained in any such suit or proceeding). 

  
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 11.04    BANKRUPTCY 

The following provisions shall apply in the event of the bankruptcy or insolvency of Tenant: 

(a)    In connection with any proceeding under Chapter 7 of the Bankruptcy Code where the trustee of Tenant elects to
assume this Lease for the purposes of assigning it, such election or assignment, may only be made upon compliance with the provisions of (b) and (c) below, which conditions Landlord and Tenant acknowledge to be commercially reasonable. In the
event the trustee elects to reject this Lease then Landlord shall immediately be entitled to possession of the Premises without further obligation to Tenant or the trustee. 

(b)    Any election to assume this Lease under Chapter 11 or 13 of the Bankruptcy Code by Tenant as debtor-in-possession or by Tenant’s trustee (the “Electing Party”) must provide for: 

The Electing Party to cure or provide to Landlord adequate assurance that it will cure all monetary defaults under this Lease within fifteen
(15) days from the date of assumption and it will cure all nonmonetary defaults under this Lease within thirty (30) days from the date of assumption. Landlord and Tenant acknowledge such condition to be commercially reasonable. 

(c)    If the Electing Party has assumed this Lease or elects to assign Tenant’s interest under this Lease to any
other person, such interest may be assigned only if the intended assignee has provided adequate assurance of future performance (as herein defined), of all of the obligations imposed on Tenant under this Lease. 

For the purposes hereof, “adequate assurance of future performance” means that Landlord has ascertained that each of the following
conditions has been satisfied: 
 (i)    The assignee has submitted a current financial statement,
certified by its chief financial officer, which shows a net worth and working capital in amounts sufficient to assure the future performance by the assignee of Tenant’s obligations under this Lease: and 

(ii)    Landlord has obtained consents or waivers from any third parties which may be required under a
lease, mortgage, financing arrangement, or other agreement by which Landlord is bound, to enable Landlord to permit such assignment. 

(d)    Landlord’s acceptance of Rent or any other payment from any trustee, receiver, assignee, person, or other
entity will not be deemed to have waived, or waive, the requirement of Landlord’s consent, Landlord’s right to terminate this Lease for any transfer of Tenant’s interest under this Lease without such consent, or Landlord’s claim
for any amount of Rent due from Tenant. 
 11.05    LANDLORD’S DEFAULT 

Landlord shall be in default hereunder in the event Landlord has not begun and pursued with reasonable diligence the cure of any failure of Landlord to meet
its obligations hereunder within thirty (30) days after the receipt by Landlord of written notice from Tenant of the alleged failure to perform. In no event shall Tenant have the right to terminate or rescind this Lease as a result of
Landlord’s default as to any covenant or agreement contained in this Lease. Tenant hereby waives such remedies of termination and rescission and hereby agrees that Tenant’s remedies for default hereunder and for breach of any promise or
inducement shall be limited to a suit for damages and/or injunction. In addition, Tenant hereby covenants that, prior to the exercise of any such remedies, it will give Mortgagee notice and a reasonable time to cure any default by Landlord. 

ARTICLE TWELVE 
 SURRENDER OF
PREMISES 
 12.01    IN GENERAL 
 Upon the
Termination Date, Tenant shall surrender and vacate the Premises immediately and deliver possession thereof to Landlord in a clean, good and tenantable condition, ordinary wear and tear, and damage caused by Landlord excepted. Tenant shall deliver
to Landlord all keys to the Premises. Tenant shall remove from the Premises all movable personal property of Tenant and Tenant’s trade fixtures, including, subject to Section 6.03, cabling for any of the foregoing. Tenant shall be entitled
to remove such Tenant Additions which at the time of their installation Landlord and Tenant agreed may be removed by Tenant. Tenant shall also remove such other Tenant Additions as 

  
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required by Landlord, including any Tenant Additions containing Hazardous Material. Tenant immediately shall repair all damage resulting from removal of any of Tenant’s property, furnishings
or Tenant Additions, shall close all floor, ceiling and roof openings and shall restore the Premises to a tenantable condition as reasonably determined by Landlord. If any of the Tenant Additions which were installed by Tenant involved the lowering
of ceilings, raising of floors or the installation of specialized wall or floor coverings or lights, then Tenant shall also be obligated to return such surfaces to their condition prior to the commencement of this Lease. Tenant shall also be
required to close any staircases or other openings between floors. Notwithstanding any of the foregoing to the contrary, (i) Tenant shall not be required to remove the initial Tenant Work (provided that it is substantially consistent with the
Alia Test Fit Plan dated January 4, 2013 prepared by WHL Architects*Planners, Inc.), and (ii) if so requested by Tenant in writing (and prominently in all capital and bold lettering which also states that such request is pursuant to
Section 12.01 of the Lease) at the time Tenant requests approval of any Tenant Work or Tenant Alterations, Landlord shall advise Tenant at the time of Landlord’s approval of such Tenant Work or Tenant Alterations as to whether Landlord
will require that such Tenant Work or Tenant Alterations be removed by Tenant from the Premises; provided, however, regardless of the foregoing, in any event, Landlord may require removal of any Tenant Work or Tenant Alterations containing Hazardous
Material and all Tenant’s trade fixtures, and, subject to Section 6.03, cabling and wiring installed for Tenant’s personal property or trade fixtures. In the event possession of the Premises is not delivered to Landlord when required
hereunder, or if Tenant shall fail to remove those items described above, Landlord may (but shall not be obligated to), at Tenant’s expense, remove any of such property and store, sell or otherwise deal with such property as provided in
Section 11.02(b), including the waiver and indemnity obligations provided in that Section, and undertake, at Tenant’s expense such restoration work as Landlord deems necessary or advisable. 

12.02    LANDLORD’S RIGHTS 
 All
property which may be removed from the Premises by Landlord shall be conclusively presumed to have been abandoned by Tenant and Landlord may deal with such property as provided in Section 11.02(b), including the waiver and indemnity obligations
provided in that Section. Tenant shall also reimburse Landlord for all costs and expenses incurred by Landlord in removing any of Tenant Additions and in restoring the Premises to the condition required by this Lease at the Termination Date. 

ARTICLE THIRTEEN 
 HOLDING OVER

 Tenant shall pay Landlord the greater of (i) one hundred fifty percent (150%) of the monthly Rent payable for the month immediately preceding the
holding over (including increases for Rent Adjustments which Landlord may reasonably estimate) or, (ii) one hundred fifty percent (150%) of the fair market rental value of the Premises as reasonably determined by Landlord for each month or
portion thereof that Tenant retains possession of the Premises, or any portion thereof, after the Termination Date (without reduction for any partial month that Tenant retains possession). Tenant shall also pay all damages sustained by Landlord by
reason of such retention of possession. The provisions of this Article shall not constitute a waiver by Landlord of any re-entry rights of Landlord and Tenant’s continued occupancy of the Premises shall
be as a tenancy in sufferance. 
 ARTICLE FOURTEEN 

DAMAGE BY FIRE OR OTHER CASUALTY 

14.01    SUBSTANTIAL UNTENANTABILITY 

(a)    If any fire or other casualty (whether insured or uninsured) renders all or a substantial portion of the Premises or
the Building untenantable, Landlord shall, with reasonable promptness after the occurrence of such damage, estimate the length of time that will be required to substantially complete the repair and restoration and shall by notice advise Tenant of
such estimate (“Landlord’s Notice”). If Landlord estimates that the amount of time required to substantially complete such repair and restoration will exceed one hundred eighty (180) days from the date such damage occurred, then
Landlord, or Tenant if all or a substantial portion of the Premises is rendered untenantable, shall have the right to terminate this Lease as of the date of such damage upon giving written notice to the other at any time within twenty (20) days
after delivery of Landlord’s Notice, provided that if Landlord so chooses, Landlord’s Notice may also constitute such notice of termination. 

(b)    In the event that the Building is damaged or destroyed to the extent of more than twenty-five percent (25%) of its
replacement cost or to any extent if no insurance proceeds or insufficient insurance proceeds are receivable by Landlord, or if the buildings at the Project shall be damaged to the extent of fifty percent (50%) or more of the replacement value or to
any extent if no insurance proceeds or insufficient insurance proceeds are receivable by Landlord, and regardless of whether or not the Premises be damaged, Landlord may elect by written notice to 

  
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Tenant given within thirty (30) days after the occurrence of the casualty to terminate this Lease in lieu of so restoring the Premises, in which event this Lease shall terminate as of the
date specified in Landlord’s notice, which date shall be no later than sixty (60) days following the date of Landlord’s notice. 

(c)    Unless this Lease is terminated as provided in the preceding Subsections 14.01 (a) and (b), Landlord shall proceed
with reasonable promptness to repair and restore the Premises to its condition as existed prior to such casualty, subject to reasonable delays for insurance adjustments and Force Majeure delays, and also subject to zoning Laws and building codes
then in effect. Landlord shall have no liability to Tenant, and Tenant shall not be entitled to terminate this Lease if such repairs and restoration are not in fact completed within the time period estimated by Landlord so long as Landlord shall
proceed with reasonable diligence to complete such repairs and restoration. 
 (d)    Tenant acknowledges that Landlord
shall be entitled to the full proceeds of any insurance coverage, whether carried by Landlord or Tenant, for damages to the Premises, except for those proceeds of Tenants insurance of its own personal property and equipment which would be removable
by Tenant at the Termination Date. All such insurance proceeds shall be payable to Landlord whether or not the Premises are to be repaired and restored, provided, however, if this Lease is not terminated and the parties proceed to repair and restore
Tenant Additions at Tenant’s cost, to the extent Landlord received proceeds of Tenants insurance covering Tenant Additions, such proceeds shall be applied to reimburse Tenant for its cost of repairing and restoring Tenant Additions. 

(e)    Notwithstanding anything in this Article Fourteen to the contrary: (i) Landlord shall have no duty pursuant to
this Section to repair or restore any portion of any Tenant Additions or to expend for any repair or restoration of the Premises or Building amounts in excess of insurance proceeds paid to Landlord and available for repair or restoration;
(ii) Tenant shall not have the right to terminate this Lease pursuant to this Section if any damage or destruction was caused by the act or neglect of Tenant, its agent or employees; and (iii) in the event that the Premises is located in
more than one building of the Project and any damage or destruction covered by this Article affects only one of the buildings in which the Premises is located, then the determination of the extent of damage or destruction shall be made only with
respect to the building so affected, and Landlord or Tenant shall be entitled to terminate this Lease only with respect to the part of the Premises in the building so affected, and the Lease shall continue in full force and effect to the extent of
the remainder, if any, of the Premises. Whether or not the Lease is terminated pursuant to this Article Fourteen, in no event shall Tenant be entitled to any compensation or damages for loss of the use of the whole or any part of the Premises or for
any inconvenience or annoyance occasioned by any such damage, destruction, rebuilding or restoration of the Premises or the Building or access thereto. 

(f)    Any repair or restoration of the Premises performed by Tenant shall be in accordance with the provisions of Article
Nine hereof. 
 14.02    INSUBSTANTIAL UNTENANTABILITY 

Unless this Lease is terminated as provided in the preceding Subsections 14.01 (a) and (b), then Landlord shall proceed to repair and restore the Building or
the Premises other than Tenant Additions, with reasonable promptness, unless such damage is to the Premises and occurs during the last twelve (12) months of the Term, in which event either Tenant or Landlord shall have the right to terminate
this Lease as of the date of such casualty by giving written notice thereof to the other within twenty (20) days after the date of such casualty. Notwithstanding the foregoing, Landlord’s obligation to repair shall be limited in accordance
with the provisions of Section 14.01 above. 
 14.03    RENT ABATEMENT 

If all or any part of the Premises are rendered untenantable by fire or other casualty and this Lease is not terminated, Monthly Base Rent and Rent Adjustments
shall abate for that part of the Premises which is untenantable on a per diem basis from the date of the casualty until Landlord has Substantially Completed the repair and restoration work in the Premises which it is required to perform, provided,
that as a result of such casualty, Tenant does not occupy the portion of the Premises which is untenantable during such period. The foregoing rent abatement shall not apply in the event the Premises are rendered untenantable by reason of a fire or
other casualty caused in whole or in part by the negligence or willful act of Tenant or its agents, employees, contractors or invitees if such abatement would adversely affect Landlord’s or Tenant’s ability to collect under any of its
insurance policies providing coverage for rental or business interruptions. 

  
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 14.04    WAIVER OF STATUTORY REMEDIES 

The provisions of this Lease, including this Article Fourteen, constitute an express agreement between Landlord and Tenant with respect to any and all damage
to, or destruction of, the Premises or the Property or any part of either, and any Law, including Sections 1932(2), 1933(4), 1941 and 1942 of the California Civil Code, with respect to any rights or obligations concerning damage or destruction shall
have no application to this Lease or to any damage to or destruction of all or any part of the Premises or the Property or any part of either, and are hereby waived. 

ARTICLE FIFTEEN 
 EMINENT DOMAIN

 15.01    TAKING OF WHOLE OR SUBSTANTIAL PART 

In the event the whole or any substantial part of the Building or of the Premises is taken or condemned by any competent authority for any public use or
purpose (including a deed given in lieu of condemnation) and is thereby rendered untenantable, this Lease shall terminate as of the date title vests in such authority or any earlier date on which possession is required to be surrendered to such
authority, and Monthly Base Rent and Rent Adjustments shall be apportioned as of the Termination Date. Notwithstanding anything to the contrary herein set forth, in the event that the Premises is located in more than one building of the Project and
any taking covered by this Article affects only one of the buildings in which the Premises is located, then the determination of the extent of the taking shall be made only with respect to the building so affected, and Landlord or Tenant shall be
entitled to terminate this Lease only with respect to the part of the Premises in the building so affected, and the Lease shall continue in full force and effect to the extent of the remainder, if any, of the Premises. Further, if at least
twenty-five percent (25%) of the rentable area of the Project is taken or condemned by any competent authority for any public use or purpose (including a deed given in lieu of condemnation), and regardless of whether or not the Premises be so taken
or condemned, Landlord may elect by written notice to Tenant to terminate this Lease as of the date title vests in such authority or any earlier date on which possession is required to be surrendered to such authority, and Monthly Base Rent and Rent
Adjustments shall be apportioned as of the Termination Date. Landlord may, without any obligation to Tenant, agree to sell or convey to the taking authority the Premises, the Building, Tenant’s Phase, the Project or any portion thereof sought
by the taking authority, free from this Lease and the right of Tenant hereunder, without first requiring that any action or proceeding be instituted or, if instituted, pursued to a judgment. Notwithstanding anything to the contrary herein set forth,
in the event the taking of the Building or Premises is temporary (for less than the remaining term of the Lease), Landlord may elect either (i) to terminate this Lease or (ii) permit Tenant to receive the entire award attributable to the
Premises in which case Tenant shall continue to pay Rent and this Lease shall not terminate, 
 15.02    TAKING OF PART 

In the event a part of the Building or the Premises is taken or condemned by any competent authority (or a deed is delivered in lieu of condemnation) and this
Lease is not terminated, the Lease shall be amended to reduce or increase, as the case may be, the Monthly Base Rent and Tenant’s Share to reflect the Rentable Area of the Premises or Building, as the case may be, remaining after any such
taking or condemnation. Landlord, upon receipt and to the extent of the award in condemnation (or proceeds of sale) shall make necessary repairs and restorations to the Premises (exclusive of Tenant Additions) and to the Building to the extent
necessary to constitute the portion of the Building not so taken or condemned as a complete architectural and economically efficient unit. Notwithstanding the foregoing, if as a result of any taking, or a governmental order that the grade of any
street or alley adjacent to the Building is to be changed and such taking or change of grade makes it necessary or desirable to substantially remodel or restore the Building or prevents the economical operation of the Building, Landlord shall have
the right to terminate this Lease upon ninety (90) days prior written notice to Tenant. 
 15.03    COMPENSATION 

Landlord shall be entitled to receive the entire award (or sale proceeds) from any such taking, condemnation or sale without any payment to Tenant, and Tenant
hereby assigns to Landlord Tenant’s interest, if any, in such award; provided, however, Tenant shall have the right separately to pursue against the condemning authority a separate award in respect of the loss, if any, to Tenant Additions paid
for by Tenant without any credit or allowance from Landlord, for fixtures or personal property of Tenant, or for relocation or business interruption expenses, so long as there is no diminution of Landlord’s award as a result. 

  
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 ARTICLE SIXTEEN 

INSURANCE 

16.01    TENANT’S INSURANCE 
 Tenant, at
Tenant’s expense, agrees to maintain in force, with a company or companies acceptable to Landlord, during the Term: (a) Commercial General Liability Insurance on a primary basis and without any right of contribution from any insurance
carried by Landlord covering the Premises on an occurrence basis against all claims for personal injury, bodily injury, death and property damage, including contractual liability covering the indemnification provisions in this Lease. Such insurance
shall be for such limits that are reasonably required by Landlord from time to time but not less than a combined single limit of Five Million Dollars ($5,000,000.00); (b) Workers’ Compensation and Employers’ Liability Insurance to the
extent required by and in accordance with the laws of the State of California; (c) “All Risks” property insurance in an amount adequate to cover the full replacement cost of all Tenant Additions to the Premises, equipment, installations,
fixtures and contents of the Premises in the event of loss; (d) In the event a motor vehicle is to be used by Tenant in connection with its business operation from the Premises, Comprehensive Automobile Liability Insurance coverage with limits
of not less than Three Million Dollars ($3,000,000.00) combined single limit coverage against bodily injury liability and property damage liability arising out of the use by or on behalf of Tenant, its agents and employees in connection with this
Lease, of any owned, non-owned or hired motor vehicles; and (e) such other insurance or coverages as Landlord reasonably requires. 

16.02    FORM OF POLICIES 
 Each policy
referred to in 16.01 shall satisfy the following requirements. Each policy shall (i) name Landlord and the Indemnitees as additional insureds (except Workers’ Compensation and Employers’ Liability Insurance), (ii) be issued by one or
more responsible insurance companies licensed to do business in the State of California reasonably satisfactory to Landlord, (iii) where applicable, provide for deductible amounts satisfactory to Landlord and not permit co-insurance, (iv) shall provide that such insurance may not be canceled or amended without thirty (30) days’ prior written notice to the Landlord, and (v) each policy of “All-Risks” property insurance shall provide that the policy shall not be invalidated should the insured waive in writing prior to a loss, any or all rights of recovery, against any other party for losses
covered by such policies. Tenant shall deliver to Landlord, certificates of insurance and at Landlord’s request, copies of all policies and renewals thereof to be maintained by Tenant hereunder, not less than ten (10) days prior to the
Commencement Date and not less than ten (10) days prior to the expiration date of each policy. 
 16.03    LANDLORD’S
INSURANCE 
 Landlord agrees to purchase and keep in full force and effect during the Term hereof, including any extensions or renewals thereof, insurance
under policies issued by insurers of recognized responsibility, qualified to do business in the State of California on the Building in amounts not less than the greater of eighty (80%) percent of the then full replacement cost (without depreciation)
of the Building (above foundations and excluding Tenant Additions to the Premises) or an amount sufficient to prevent Landlord from becoming a co-insurer under the terms of the applicable policies, against
fire and such other risks as may be included in standard forms of all risk coverage insurance reasonably available from time to time. Landlord agrees to maintain in force during the Term, Commercial General Liability Insurance covering the Building
on an occurrence basis against all claims for personal injury, bodily injury, death and property damage. Such insurance shall be for a combined single limit of Five Million Dollars ($5,000,000.00). Neither Landlord’s obligation to carry such
insurance nor the carrying of such insurance shall be deemed to be an indemnity by Landlord with respect to any claim, liability, loss, cost or expense due, in whole or in part, to Tenant’s negligent acts or omissions or willful misconduct.
Without obligation to do so, Landlord may, in its sole discretion from time to time, carry insurance in amounts greater and/or for coverage additional to the coverage and amounts set forth above. 

16.04    WAIVER OF SUBROGATION 

(a)    Landlord agrees that, if obtainable at no, or minimal, additional cost, and so long as the same is permitted under
the laws of the State of California, it will include in its “All Risks” policies appropriate clauses pursuant to which the insurance companies (i) waive all right of subrogation against Tenant with respect to losses payable under such
policies and/or (ii) agree that such policies shall not be invalidated should the insured waive in writing prior to a loss any or all right of recovery against any party for losses covered by such policies. 

(b)    Tenant agrees to include, if obtainable at no, or minimal, additional cost, and so long as the same is permitted
under the laws of the State of California, in its “All Risks” insurance policy or policies on Tenant Additions to the Premises, whether or not removable, and on Tenant’s furniture, furnishings, fixtures and other property

  
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removable by Tenant under the provisions of this Lease appropriate clauses pursuant to which the insurance company or companies (i) waive the, right of subrogation against Landlord and/or
any tenant of space in the Building with respect to losses payable under such policy or policies and/or (ii) agree that such policy or policies shall not be invalidated should the insured waive in writing prior to a loss any or all right of
recovery against any party for losses covered by such policy or policies. If Tenant is unable to obtain in such policy or policies either of the clauses described in the preceding sentence, Tenant shall, if legally possible and without necessitating
a change in insurance carriers, have Landlord named in such policy or policies as an additional insured. If Landlord shall be named as an additional insured in accordance with the foregoing, Landlord agrees to endorse promptly to the order of
Tenant, without recourse, any check, draft or order for the payment of money representing the proceeds of any such policy or representing any other payment growing out of or connected with said policies, and Landlord does hereby irrevocably waive
any and all rights in and to such proceeds and payments. 
 (c)    Provided that Landlord’s right of full recovery
under its policy or policies aforesaid is not adversely affected or prejudiced thereby, Landlord hereby waives any and all right of recovery which it might otherwise have against Tenant, its servants, agents and employees, for loss or damage
occurring to the Real Property and the fixtures, appurtenances and equipment therein, except Tenant Additions, to the extent the same is covered by Landlord’s insurance, notwithstanding that such loss or damage may result from the negligence or
fault of Tenant, its servants, agents or employees. Provided that Tenant’s right of full recovery under its aforesaid policy or policies is not adversely affected or prejudiced thereby, Tenant hereby waives any and all right of recovery which
it might otherwise have against Landlord, its servants, and employees and against every other tenant in the Real Property who shall have executed a similar waiver as set forth in this Section 16.04 (c) for loss or damage to Tenant Additions,
whether or not removable, and to Tenant’s furniture, furnishings, fixtures and other property removable by Tenant under the provisions hereof to the extent the same is covered or coverable by Tenant’s insurance required under this Lease,
notwithstanding that such loss or damage may result from the negligence or fault of Landlord, its servants, agents or employees, or such other tenant and the servants, agents or employees thereof. 

(d)    Landlord and Tenant hereby agree to advise the other promptly if the clauses to be included in their respective
insurance policies pursuant to subparagraphs (a) and (b) above cannot be obtained on the terms hereinbefore provided and thereafter to furnish the other with a certificate of insurance or copy of such policies showing the naming of the other as
an additional insured, as aforesaid. Landlord and Tenant hereby also agree to notify the other promptly of any cancellation or change of the terms of any such policy which would affect such clauses or naming. All such policies which name both
Landlord and Tenant as additional insureds shall, to the extent obtainable, contain agreements by the insurers to the effect that no act or omission of any additional insured will invalidate the policy as to the other additional insureds. 

16.05    NOTICE OF CASUALTY 
 Tenant shall
give Landlord notice in case of a fire or accident in the Premises promptly after Tenant is aware of such event. 
 ARTICLE SEVENTEEN 

WAIVER OF CLAIMS AND INDEMNITY 

17.01    WAIVER OF CLAIMS 
 To the extent
permitted by Law, Tenant releases the Indemnitees from, and waives all claims for, damage to person or property sustained by the Tenant or any occupant of the Premises or the Property resulting directly or indirectly from any existing or future
condition, defect, matter or thing in and about the Premises or the Property, or any part of either, or any equipment or appurtenance therein, or resulting from any accident in or about the Premises or the Property, or resulting directly or
indirectly from any act or neglect of any tenant or occupant of the Property or of any other person, including Landlord’s agents and servants, except to the extent caused by the willful and wrongful act of any of the Indemnitees. If any such
damage, whether to the Premises or the Property or any part of either, or whether to Landlord or to other tenants in the Property, results from any act or neglect of Tenant, its employees, servants, agents, contractors, invitees or customers, Tenant
shall be liable therefor and Landlord may, at Landlord’s option, repair such damage and Tenant shall, upon demand by Landlord, as payment of additional Rent hereunder, reimburse Landlord within ten (10) days of demand for the total cost of
such repairs, in excess of amounts, if any, paid to Landlord under insurance covering such damages. Tenant shall not be liable for any such damage caused by its acts or neglect if Landlord or a tenant has recovered the full amount of the damage from
proceeds of insurance policies and the insurance company has waived its right of subrogation against Tenant. 

  
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 17.02    INDEMNITY BY TENANT 

To the extent permitted by Law, Tenant hereby indemnifies, and agrees to protect, defend and hold the Indemnitees harmless, against any and all actions,
claims, demands, liability, costs and expenses, including attorneys’ fees and expenses for the defense thereof, arising from Tenants occupancy of the Premises, from the undertaking of any Tenant Additions or repairs to the Premises, from the
conduct of Tenant’s business on the Premises, or from any breach or default on the part of Tenant in the performance of any covenant or agreement on the part of Tenant to be performed pursuant to the terms of this Lease, or from any willful act
or negligence of Tenant, its agents, contractors, servants, employees, customers or invitees, in or about the Premises or the Property or any part of either. In case of any action or proceeding brought against the Indemnitees by reason of any such
claim, upon notice from Landlord, Tenant covenants to defend such action or proceeding by counsel chosen by Tenant and reasonably acceptable to Landlord. Landlord and Tenant may settle, compromise or dispose of any and all actions, claims and
demands related to the foregoing indemnity, subject to the prior written approval of the other, which approval shall not be unreasonably withheld. The foregoing indemnity shall not operate to relieve Indemnitees of liability to the extent such
liability is caused by the willful and wrongful act of Indemnitees. Further, the foregoing indemnity is subject to and shall not diminish any waivers in effect in accordance with Section 16.04 by Landlord or its insurers to the extent of
amounts, if any, paid to Landlord under its “All-Risks” property insurance. 

17.03    WAIVER OF CONSEQUENTIAL DAMAGES 
 To
the extent permitted by law, Tenant hereby waives and releases the Indemnitees from any consequential damages, compensation or claims for inconvenience or loss of business, rents or profits as a result of any injury or damage, whether or not caused
by the willful and wrongful act of any of the Indemnitees. 
 ARTICLE EIGHTEEN 

RULES AND REGULATIONS 

18.01    RULES 
 Tenant agrees for itself and
for its subtenants, employees, agents, and invitees to comply with all rules and regulations for use of the Premises, the Building, the Phase and the Project imposed by Landlord, as the same may be revised from time to time, including the following:
(a) Tenant shall comply with all of the requirements of Landlord’s emergency response plan, as the same may be amended from time to time: and (b) Tenant shall not place any furniture, furnishings, fixtures or equipment in the Premises
in a manner so as to obstruct the windows of the Premises to cause the Building, in Landlord’s good faith determination, to appear unsightly from the exterior. Such rules and regulations are and shall be imposed for the cleanliness, good
appearance, proper maintenance, good order and reasonable use of the Premises, the Building, the Phase and the Project and as may be necessary for the enjoyment of the Building and the Project by all tenants and their clients, customers, and
employees. 
 18.02    ENFORCEMENT 

Nothing in this Lease shall be construed to impose upon the Landlord any duty or obligation to enforce the rules and regulations as set forth above or as
hereafter adopted, or the terms, covenants or conditions of any other lease as against any other tenant, and the Landlord shall not be liable to the Tenant for violation of the same by any other tenant, its servants, employees, agents, visitors or
licensees. 
 ARTICLE NINETEEN 

LANDLORD’S RESERVED RIGHTS 
 Landlord shall
have the following rights exercisable without notice to Tenant and without liability to Tenant for damage or injury to persons, property or business and without being deemed an eviction or disturbance of Tenant’s use or possession of the
Premises or giving rise to any claim for offset or abatement of Rent: (1) to change the Building’s name or street address upon thirty (30) days’ prior written notice to Tenant; (2) to install, affix and maintain all signs on
the exterior and/or interior of the Building; (3) to designate and/or approve prior to installation, all types of signs, window shades, blinds, drapes, awnings or other similar items, and all internal lighting that may be visible from the
exterior of the Premises: (4) upon reasonable notice to Tenant, to display the Premises to prospective purchasers at reasonable hours at any time during the Term and to prospective tenants at reasonable hours during the last twelve
(12) months of the Term; (5) to grant to any party the exclusive right to conduct any business or render any service in or to the Building, provided such exclusive right shall not operate to prohibit Tenant from using the Premises for the
purpose permitted hereunder: (6) to change the arrangement and/or location of entrances or passageways, doors and doorways, corridors, elevators, stairs, washrooms or public portions of the Building, and to close entrances,

  
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doors corridors, elevators or other facilities, provided that such action shall not materially and adversely interfere with Tenant access to the Premises or the Building; (7) to have access
for Landlord and other tenants of the Building to any alga chutes and boxes located in or on the Premises as required by any applicable rules of the United States Post Office; and (8) to close the Building after Standard Operating Hours, except
that Tenant and its employees and invitees shall be entitled to admission at all times, under such regulations as Landlord prescribes for security purposes. 

ARTICLE TWENTY 
 ESTOPPEL
CERTIFICATE 
 20.01    IN GENERAL 
 Within
fifteen (15) days after request therefor by Landlord, Mortgagee or any prospective mortgagee or owner, Tenant agrees as directed in such request to execute an Estoppel Certificate in recordable form, binding upon Tenant, certifying
(i) that this Lease is unmodified and in full force and effect (or if there have been modifications, a description of such modifications and that this Lease as modified is in full force and effect); (ii) the dates to which Rent has been paid;
(iii) that Tenant is in the possession of the Premises if that is the case (iv) that Landlord is not in default under this Lease, or, if Tenant believes Landlord is in default, the nature thereof in detail: (v) that Tenant has no
offsets or defenses to the performance of its obligations under this Lease (or if Tenant believes there are any offsets or defenses, a full and complete explanation thereof); (vi) that the Premises have been completed in accordance with the terms
and provisions hereof, that Tenant has accepted the Premises and the condition thereof and of all improvements thereto and has no claims against Landlord or any other party with respect thereto; (vii) that if an assignment of rents or leases
has been served upon the Tenant by a Mortgagee, Tenant will acknowledge receipt thereof and agree to be bound by the provisions thereof; (viii) that Tenant will give to the Mortgagee copies of all notices required or permitted to be given by
Tenant to Landlord; and (ix) to any other information reasonably requested. 
 20.02    ENFORCEMENT 

In the event that Tenant fails to deliver an Estoppel Certificate and such failure continues for five (5) days after written notice of such failure, then
such failure shall be a Default for which there shall be no additional cure or grace period. In addition to any other remedy available to Landlord, Landlord may impose a charge equal to $500.00 for each day that Tenant fails to deliver an Estoppel
Certificate. 
 ARTICLE TWENTY-ONE 

INTENTIONALLY OMITTED 
 ARTICLE TWENTY-TWO 
 REAL ESTATE BROKERS 

Tenant represents that in connection with this Lease it is represented by Tenant’s Broker identified in Section 1.01 and, except for Tenant’s
Broker and Landlord’s Broker identified in Section 1.01, Tenant has not dealt with any real estate broker, sales person, or finder in connection with this Lease, and no such person initiated or participated in the negotiation of this
Lease. Tenant hereby indemnifies and agrees to protect, defend and hold Landlord and Landlord’s Broker harmless from and against all claims, losses, damages, liability, costs and expenses (including, without limitation, attorneys’ fees and
expenses) by virtue of any broker, agent or other person claiming a commission or other form of compensation by virtue of alleged representation of, or dealings or discussions with, Tenant with respect to the subject matter of this Lease, except for
Landlord’s Broker and except for a commission payable to Tenant’s Broker to the extent provided for in a separate written agreement between Tenant’s Broker and Landlord’s Broker. Tenant is not obligated to pay or fund any amount
to Landlord’s Broker, and Landlord hereby agrees to pay such commission, if any, to which Landlord’s Broker is entitled in connection with the subject matter of this Lease pursuant to Landlord’s separate written agreement with
Landlord’s Broker. Such commission shall include an amount to be shared by Landlord’s Broker with Tenant’s Broker to the extent that Tenant’s Broker and Landlord’s Broker have entered into a separate agreement between
themselves to share the commission paid to Landlord’s Broker by Landlord. The provisions of this Section shall survive the expiration or earlier termination of the Lease. 

  
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 ARTICLE TWENTY-THREE 

MORTGAGEE PROTECTION 

23.01    SUBORDINATION AND ATTORNMENT 
 This
Lease is and shall be expressly subject and subordinate at all times to (i) any ground or underlying lease of the Real Property, now or, provided the applicable ground lessor tenders a commercially reasonable
non-disturbance agreement to Tenant, hereafter existing, and all amendments, extensions, renewals and modifications to any such lease, and (ii) the lien of any mortgage or trust deed now or, provided the
Mortgagee tenders a commercially reasonable non-disturbance agreement to Tenant, hereafter encumbering fee title to the Real Property and/or the leasehold estate under any such lease, and all amendments,
extensions, renewals, replacements and modifications of such mortgage or trust deed and/or the obligation secured thereby, unless such ground lease or ground lessor, or mortgage, trust deed or Mortgagee, expressly provides or elects that the Lease
shall be superior to such lease or mortgage or trust deed. If any such mortgage or trust deed is foreclosed (including any sale of the Real Property pursuant to a power of sale), or if any such lease is terminated, upon request of the Mortgagee or
ground lessor, as the case may be, Tenant shall attorn to the purchaser at the foreclosure sale or to the ground lessor under such lease, as the case may be, provided, however, that such purchaser or ground lessor shall not be (i) bound by any
payment of Rent for more than one month in advance except payments in the nature of security for the performance by Tenant of its obligations under this Lease; (ii) subject to any offset, defense or damages arising out of a default of any
obligations of any preceding Landlord; or (iii) bound by any amendment or modification of this Lease made without the written consent of the Mortgagee or ground lessor: or (iv) liable for any security deposits not actually received in cash
by such purchaser or ground lessor. This subordination shall be self-operative and no further certificate or instrument of subordination need be required by any such Mortgagee or ground lessor. In confirmation of such subordination, however, Tenant
shall execute promptly any reasonable certificate or instrument that Landlord, Mortgagee or ground lessor may request. Tenant hereby constitutes Landlord as Tenant’s
attorney-in-fact to execute such certificate or instrument for and on behalf of Tenant upon Tenant’s failure to do so within fifteen (15) days of a request to
do so. Upon request by such successor in interest, Tenant shall execute and deliver reasonable instruments confirming the attornment provided for herein. 

23.02    MORTGAGEE PROTECTION 
 Tenant agrees
to give any Mortgagee or ground lessor, by registered or certified mail, a copy of any notice of default served upon the Landlord by Tenant, provided that prior to such notice Tenant has received notice (by way of service on Tenant of a copy of an
assignment of rents and leases, or otherwise) of the address of such Mortgagee or ground lessor. Tenant further agrees that if Landlord shall have failed to cure such default within the time provided for in this Lease, then the Mortgagee or ground
lessor shall have an additional thirty (30) days after receipt of notice thereof within which to cure such default or if such default cannot be cured within that time, then such additional notice time as may be necessary, if, within such thirty
(30) days, any Mortgagee or ground lessor has commenced and is diligently pursuing the remedies necessary to cure such default (including commencement of foreclosure proceedings or other proceedings to acquire possession of the Real Property,
if necessary to effect such cure). Such period of time shall be extended by any period within which such Mortgagee or ground lessor is prevented from commencing or pursuing such foreclosure proceedings or other proceedings to acquire possession of
the Real Property by reason of Landlord’s bankruptcy. Until the time allowed as aforesaid for Mortgagee or ground lessor to cure such defaults has expired without cure, Tenant shall have no right to, and shall not, terminate this Lease on
account of default. This Lease may not be modified or amended so as to reduce the Rent or shorten the Term, or so as to adversely affect in any other respect to any material extent the rights of the Landlord, nor shall this Lease be canceled or
surrendered, without the prior written consent, in each instance, of the ground lessor or the Mortgagee. 
 ARTICLE TWENTY-FOUR 

NOTICES 

(a)    All notices, demands or requests provided for or permitted to be given pursuant to this Lease must be in writing
and shall be personally delivered, sent by Federal Express or other reputable overnight courier service, or mailed by first class, registered or certified United States mail, return receipt requested, postage prepaid. 

(b)    All notices, demands or requests to be sent pursuant to this Lease shall be deemed to have been properly given or
served by delivering or sending the same in accordance with this Section, addressed to the parties hereto at their respective addresses listed in Sections 1.01(2) and (3). 

(c)    Notices, demands or requests sent by mail or overnight courier service as described above shall be effective upon
deposit in the mail or with such courier service. However, the time period in which a response to any 

  
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such notice, demand or request must be given shall commence to run from (i) in the case of delivery by mail, the date of receipt on the return receipt of the notice, demand or request by the
addressee thereof, or (ii) in the case of delivery by Federal Express or other overnight courier service, the date of acceptance of delivery by an employee, officer, director or partner of Landlord or Tenant. Rejection or other refusal to
accept or the inability to deliver because of changed address of which no notice was given, as indicated by advice from Federal Express or other overnight courier service or by mail return receipt, shall be deemed to be receipt of notice, demand or
request sent. Notices may also be served by personal service upon any officer, director or partner of Landlord or Tenant, and shall be effective upon such service. 

(d)    By giving to the other party at least thirty (30) days written notice thereof, either party shall have the
right from time to time during the term of this Lease to change its respective addresses for notices, statements, demands and requests, provided such new address shall be within the United States of America. 

ARTICLE TWENTY-FIVE 
 EXERCISE
FACILITY 
 Tenant agrees to inform all employees of Tenant of the following: (i) the exercise facility is available for the use of the employees of
tenants of the Project only and for no other person; (ii) use of the facility is at the risk of Tenant or Tenant’s employees, and all users must sign a release; (iii) the facility is unsupervised: and (iv) users of the facility
must report any needed equipment maintenance or any unsafe conditions to the Landlord immediately. Landlord may discontinue providing such facility at Landlord’s sole option at any time without incurring any liability. As a condition to the use
of the exercise facility, Tenant and each of Tenant’s employees that uses the exercise facility shall first sign a written release in form and substance acceptable to Landlord. Landlord may change the rules and/or hours of the exercise facility
at any time, and Landlord reserves the right to deny access to the exercise facility to anyone due to misuse of the facility or noncompliance with rules and regulations of the facility. To the extent permitted by Law, Tenant hereby indemnifies, and
agrees to protect, defend and hold the Indemnitees harmless, against any and all actions, claims, demands, liability, costs and expenses, including attorneys’ fees and expenses for the defense thereof, arising from use of the exercise facility
in the Project by Tenant, Tenants employees or invitees. In case of any action or proceeding brought against the Indemnitees by reason of any such claim, upon notice from Landlord, Tenant covenants to defend such action or proceeding by counsel by
Tenant and reasonably acceptable to Landlord. Landlord and Tenant may settle, compromise or dispose of any and all actions, claims and demands related to the foregoing indemnity, subject to the prior written approval of the other, which approval
shall not be unreasonably withheld. 
 ARTICLE TWENTY-SIX 

OFAC 
 Landlord advises Tenant hereby that the
purpose of this Article is to provide to the Landlord information and assurances to enable Landlord to comply with the law relating to OFAC. 
 Tenant
hereby represents, warrants and covenants to Landlord, either that (i) Tenant is regulated by the SEC, FINRA or the Federal Reserve (a “Regulated Entity”) or (ii) neither Tenant nor any person or entity that directly or
indirectly (a) controls Tenant or (b) has an ownership interest in Tenant of twenty-five percent (25%) or more, appears on the list of Specially Designated Nationals and Blocked Persons (“OFAC List”) published by the Office of
Foreign Assets Control (“OFAC”) of the U.S. Department of the Treasury. 
 If, in connection with this Lease, there is one or more Guarantors of
Tenant’s obligations under this Lease, then Tenant further represents, warrants and covenants either that (i) any such Guarantor is a Regulated Entity or (ii) neither Guarantor nor any person or entity that directly or indirectly
(a) controls such Guarantor or (b) has an ownership interest in such Guarantor of twenty-five percent (25%) or more, appears on the OFAC List. 

Tenant covenants that during the term of this Lease to provide to Landlord information reasonably requested by Landlord including without limitation,
organizational structural charts and organizational documents which Landlord may deem to be necessary (“Tenant OFAC Information”) in order for Landlord to confirm Tenant’s continuing compliance with the provisions of this Article.
Tenant represents and warrants that the Tenant OFAC Information it has provided or to be provided to Landlord or Landlord’s Broker in connection with the execution of this Lease is true and complete. 

  
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 ARTICLE TWENTY-SEVEN 

MISCELLANEOUS 
 27.01    LATE
CHARGES 
 (a)    The Monthly Base Rent, Rent Adjustments and Rent Adjustment Deposits shall be due when and as
specifically provided above, Except for such payments and late charges described below, which late charge shall be due when provided below (without notice or demand), all other payments required hereunder to Landlord shall be paid within twenty
(20) days after Landlord’s demand therefor. All Rent and charges, except late charges, not paid when due shall bear interest from the date due until the date paid at the Default Rate in effect on the date such payment was due. 

(b)    In the event Tenant is more than five (5) days late in paying any installment of Rent due under this Lease,
Tenant shall pay Landlord a late charge equal to five percent (5%) of the delinquent installment of Rent. The parties agree that (i) such delinquency will cause Landlord to incur costs and expenses not contemplated herein, the exact amount of
which will be difficult to calculate, including the cost and expense that will be incurred by Landlord in processing each delinquent payment of rent by Tenant, and (ii) the amount of such late charge represents a reasonable estimate of such
costs and expenses and that such late charge shall be paid to Landlord for each delinquent payment in addition to all Rent otherwise due hereunder. The parties further agree that the payment of late charges and the payment of interest provided for
in subparagraph (a) above are distinct and separate from one another in that the payment of interest is to compensate Landlord for its inability to use the money improperly withheld by Tenant, while the payment of late charges is to compensate
Landlord for its additional administrative expenses in handling and processing delinquent payments. 
 (c)    Payment of
interest at the Default Rate and/or of late charges shall not excuse or cure any default by Tenant under this Lease, nor shall the foregoing provisions of this Article or any such payments prevent Landlord from exercising any right or remedy
available to Landlord upon Tenant’s failure to pay Rent when due, including the right to terminate this Lease. 
 27.02    NO JURY
TRIAL; VENUE: JURISDICTION 
 To the extent permitted by Law, each party hereto (which includes any assignee, successor, heir or personal representative of a
party) shall not seek a jury trial, hereby waives trial by jury, and hereby further waives any objection to venue in the County in which the Project is located, and agrees and consents to personal jurisdiction of the courts of the State of
California, in any action or proceeding or counterclaim brought by any party hereto against the other on any matter whatsoever arising out of or in any way connected with this Lease, the relationship of Landlord and Tenant, Tenant’s use or
occupancy of the Premises, or any claim of injury or damage, or the enforcement of any remedy under any statute, emergency or otherwise, whether any of the foregoing is based on this Lease or on tort law. No party will seek to consolidate any such
action in which a jury has been waived with any other action in which a jury trial cannot or has not been waived. It is the intention of the parties that these provisions shall be subject to no exceptions. By execution of this Lease the parties
agree that this provision may be filed by any party hereto with the clerk or judge before whom any action is instituted, which filing shall constitute the written consent to a waiver of jury trial pursuant to and in accordance with Section 631
of the California Code of Civil Procedure. No party has in any way agreed with or represented to any other party that the provisions of this Section will not be fully enforced in all instances. The provisions of this Section shall survive the
expiration or earlier termination of this Lease. 
 27.03    DEFAULT UNDER OTHER LEASE 

It shall be a Default under this Lease if Tenant or any Affiliate holding any other lease with Landlord for premises in the Project defaults under such lease
and as a result thereof such lease is terminated or terminable. 
 27.04    OPTION 

This Lease shall not become effective as a lease or otherwise until executed and delivered by both Landlord and Tenant. The submission of the Lease to Tenant
does not constitute a reservation of or option for the Premises, but when executed by Tenant and delivered to Landlord, the Lease shall constitute an irrevocable offer by Tenant in effect for fifteen (15) days to lease the Premises on the terms
and conditions herein contained. 

  
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 27.05    TENANT AUTHORITY 

Tenant represents and warrants to Landlord that it has full authority and power to enter into and perform its obligations under this Lease, that the person
executing this Lease is fully empowered to do so, and that no consent or authorization is necessary from any third party. Landlord may request that Tenant provide Landlord evidence of Tenant’s authority. 

27.06    ENTIRE AGREEMENT 
 This Lease, the
Exhibits and Riders attached hereto contain the entire agreement between Landlord and Tenant concerning the Premises and there are no other agreements, either oral or written, and no other representations or statements, either oral or written, on
which Tenant has relied. This Lease shall not be modified except by a writing executed by Landlord and Tenant. 
 27.07    MODIFICATION
OF LEASE FOR BENEFIT OF MORTGAGEE 
 If Mortgagee of Landlord requires a modification of this Lease which shall not result in any increased cost or expense
to Tenant or in any other substantial and adverse change in the rights and obligations of Tenant hereunder, then Tenant agrees that the Lease may be so modified. 

27.08    EXCULPATION 
 Tenant agrees, on its
behalf and on behalf of its successors and assigns, that any liability or obligation of Landlord in connection with this Lease shall only be enforced against Landlord’s equity interest in the Property up to a maximum of Five Million Dollars
($5,000,000.00) and in no event against any other assets of the Landlord, or Landlord’s officers or directors or partners, and that any liability of landlord with respect to this Lease shall be so limited and Tenant shall not be entitled to any
judgment in excess of such amount. 
 27.09    ACCORD AND SATISFACTION 

No payment by Tenant or receipt by Landlord of a lesser amount than any installment or payment of Rent due shall be deemed to be other than on account of the
amount due, and no endorsement or statement on any check or any letter accompanying any check or payment of Rent shall be deemed an accord and satisfaction, and Landlord may accept such check or payment without prejudice to Landlord’s right to
recover the balance of such installment or payment of Rent or pursue any other remedies available to Landlord. No receipt of money by Landlord from Tenant after the termination of this Lease or Tenant’s right of possession of the Premises shall
reinstate, continue or extend the Term. Receipt or acceptance of payment from anyone other than Tenant, including an assignee of Tenant, is not a waiver of any breach of Article Ten, and Landlord may accept such payment on account of the amount due
without prejudice to Landlord’s right to pursue any remedies available to Landlord. 
 27.10    LANDLORD’S OBLIGATIONS ON SALE
OF BUILDING 
 In the event of any sale or other transfer of the Building, Landlord shall be entirely freed and relieved of all agreements and obligations of
Landlord hereunder accruing or to be performed after the date of such sale or transfer, and any remaining liability of Landlord with respect to this Lease shall be limited to Five Million Dollars ($5,000,000.00) and Tenant shall not be entitled to
any judgment in excess of such amount. 
 27.11    BINDING EFFECT 

Subject to the provisions of Article Ten, this Lease shall be binding upon and inure to the benefit of Landlord and Tenant and their respective heirs, legal
representatives, successors and permitted assigns. 
 27.12    CAPTIONS 

The Article and Section captions in this Lease are inserted only as a matter of convenience and in no way define, limit, construe, or describe the scope or
intent of such Articles and Sections. 

  
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 27.13    TIME: APPLICABLE LAW: CONSTRUCTION 

Time is of the essence of this Lease and each and all of its provisions. This Lease shall be construed in accordance with the Laws of the State of California.
If more than one person signs this Lease as Tenant, the obligations hereunder imposed shall be joint and several. If any term, covenant or condition of this Lease or the application thereof to any person or circumstance shall, to any extent, be
invalid or unenforceable, the remainder of this Lease, or the application of such term, covenant or condition to persons or circumstances other than those as to which it is held invalid or unenforceable, shall not be affected thereby and each item,
covenant or condition of this Lease shall be valid and be enforced to the fullest extent permitted by Law. Wherever the term “including” or “includes” is used in this Lease, it shall have the same meaning as if followed by the
phrase “but not limited to”. The language in all parts of this Lease shall be construed according to its normal and usual meaning and not strictly for or against either Landlord or Tenant. 

27.14    ABANDONMENT 
 In the event Tenant
vacates or abandons the Premises but is otherwise in compliance with all the terms, covenants and conditions of this Lease, Landlord shall (i) have the right to enter into the Premises in order to show the space to prospective tenants,
(ii) have the right to reduce the services provided to Tenant pursuant to the terms of this Lease to such levels as Landlord reasonably determines to be adequate services for an unoccupied premises and (iii) during the last six
(6) months of the Term, have the right to prepare the Premises for occupancy by another tenant upon the end of the Term. Tenant expressly acknowledges that in the absence of written notice pursuant to Section 11.02(b) or pursuant to
California Civil Code Section 1951.3 terminating Tenant’s right to possession, none of the foregoing acts of Landlord or any other act of Landlord shall constitute a termination of Tenant’s right to possession or an acceptance of
Tenant’s surrender of the Premises, and the Lease shall continue in effect. 
 27.15    LANDLORD’S RIGHT TO PERFORM
TENANT’S DUTIES 
 If Tenant fails timely to perform any of its duties under this Lease, Landlord shall have the right (but not the obligation), to
perform such duty on behalf and at the expense of Tenant without prior notice to Tenant, and all sums expended or expenses incurred by Landlord in performing such duty shall be deemed to be additional Rent under this Lease and shall be due and
payable upon demand by Landlord. 
 27.16    SECURITY SYSTEM 

Landlord shall not be obligated to provide or maintain any security patrol or security system. Landlord shall not be responsible for the quality of any such
patrol or system which may be provided hereunder or for damage or injury to Tenant, its employees, invitees or others due to the failure, action or inaction of such patrol or system. 

27.17    NO LIGHT, AIR OR VIEW EASEMENTS 

Any diminution or shutting off of light, air or view by any structure which may be erected on lands of or adjacent to the Project shall in no way affect this
Lease or impose any liability on Landlord. 
 27.18    RECORDATION 

Neither this Lease, nor any notice nor memorandum regarding the terms hereof, shall be recorded by Tenant. Any such unauthorized recording shall be a Default
for which there shall be no cure or grace period. Tenant agrees to execute and acknowledge, at the request of Landlord, a memorandum of this Lease, in recordable form. 

27.19    SURVIVAL 
 The waivers of the right
of jury trial, the other waivers of claims or rights, the releases and the obligations of Tenant under this Lease to indemnify, protect, defend and hold harmless Landlord and/or Indemnitees shall survive the expiration or termination of this Lease,
and so shall all other obligations or agreements which by their terms survive expiration or termination of the Lease. 

27.20    EXHIBITS OR RIDERS 
 All exhibits,
riders and/or addenda referred to in this Lease as an exhibit, addenda or rider hereto or attached hereto, are hereby incorporated into and made a part of this Lease. 

  
 36 

 IN WITNESS WHEREOF, this Lease has been executed as of the date set forth in Section 1.01(4) hereof. 

 

									
	TENANT	  		  	LANDLORD
			
	ARMO BIOSCIENCES, INC.,	  		  	 METROPOLITAN LIFE INSURANCE COMPANY,

a New York corporation

					
	By:	  	 /s/ Peter Van Vlasselaer
	  		  	By:	  	 /s/ Greg Hill

		  	Peter Van Vlasselaer	  		  		  	Greg Hill
		  	Print Name	  		  		  	Print Name
					
	Its:	  	 CEO
	  		  	Its:	  	 Director

		  	Chairman of the Board, President or Vice President)	  		  		  	
					
	By:	  	 /s/ Marcia Hatch
	  		  		  	
		  	Marcia Hatch	  		  		  	
		  	Print Name	  		  		  	
					
	Its:	  	 Asst. Secretary
	  		  		  	
		  	(Secretary, Assistant Secretary, CFO or Assistant Treasurer)	  		  		  	

  
 37 

 EXHIBIT A 

Premises 
  
 

 

  
 E-1 

 EXHIBIT B 

WORKLETTER AGREEMENT 
 (TENANT
BUILD) 
 This Workletter Agreement (“Workletter”) is attached to and a part of a certain Lease by and between Metropolitan Life
Insurance Company, a New York corporation, as Landlord, and ARMO Biosciences, Inc., a Delaware corporation, as Tenant, for the Premises (the “Lease”). Terms used herein and not defined herein shall have the meaning of such terms as defined
elsewhere in the Lease. For purposes of this Workletter, references to “State” and “City” shall mean the State and City in which the Building is located. 

1.    AS IS Condition; Delivery. 

Landlord shall deliver the Premises broom clean in its current “as built” configuration with existing
build-out of the tenant space, with the Premises and the Building (including the “Base Building”, as defined below) in their AS IS condition, without any express or implied representations or
warranties of any kind by Landlord, its brokers, manager or agents, or the employees of any of them; and Landlord shall not have any obligation to construct or install any tenant improvements or alterations or to pay for any such construction or
installation except to the extent expressly provided in this Workletter. For purposes hereof, the “Base Building” (sometimes also referred to as the “Base Building Work”) shall mean the improvements made and work performed during
the Building’s initial course of construction and modifications thereto, excluding all original and modified build-outs of any tenant spaces. Notwithstanding any provision of this Workletter or the Lease to the contrary, if and to the extent
that within thirty (30) days after the earlier of (a) the date that Tenant first occupies all or part of the Premises for the conduct of business or (b) June 1, 2013, Tenant gives Landlord written notice specifying which, of the
systems listed below is not in good operating condition, Landlord shall inspect such item or items and make necessary repairs or replacements to put such item or items in good operating condition: 

(i)    foundation (excluding slab) and structural components of the Base Building: 

(ii)    Landlord’s fire sprinkler and life-safety systems, if any, of the Base Building; 

(iii)    the electrical, gas (if any), water, sewer and plumbing systems of the Base Building serving the Premises (but
only from the local utility’s systems to the point of entry into the Premises or to the meter or other point after which such system serves exclusively the Premises): 

(iv)    lighting of the Base Building within the Premises (which is acknowledged and agreed to exclude any supplemental or
special lighting installed by any prior tenant or occupant); 
 (v)    standard heating, ventilating and air conditioning
systems (HVAC) of the Base Building serving the Premises (which is acknowledged and agreed to exclude any supplemental or special HVAC units or systems installed by any prior tenant or occupant); and 

(vi)    loading doors, if, any, of the Base Building serving the Premises. 

Provided, however, Landlord shall have no obligation to repair or replace any such item to the extent it will be, or is in fact, removed, demolished or
altered by Tenant, or to the extent an act or omission of Tenant, its employees, agents, contractors or invitees has caused the failure to operate properly. 

2.    Landlord Work. 

There shall be no Landlord Work 

  
 E-2 

 3.    Tenant’s Plans. 

3.1.    Description. At its expense, Tenant shall employ: 

(i)    one or more architects reasonably satisfactory to Landlord and licensed by the State (“Tenant’s
Architect”) to prepare architectural drawings and specifications for all layout and Premises improvements not included in, or requiring any change or addition to, the AS IS condition and Landlord Work, if any. 

(ii)    one or more engineers reasonably satisfactory to Landlord and licensed by the State (“Tenant’s
Engineers’) to prepare structural, mechanical and electrical working drawings and specifications for all Premises improvements not included in, or requiring any change or addition to, the AS IS condition and Landlord Work, if any. 

All such drawings and specifications are referred to herein as “Tenant’s Plans”. Tenant’s Plans shall be in form and detail sufficient to
secure all applicable governmental approvals. Tenant’s Architect shall be responsible for coordination of all engineering work for Tenant’s Plans and shall coordinate with any consultants of Tenant (the use of which is subject to
Landlord’s consent), and Landlord’s space planner or architect to assure the consistency of Tenant’s Plans with the Base Building Work and Landlord Work (if any). 

Tenant shall pay Landlord, within twenty (20) days of receipt of each invoice from Landlord, the cost incurred by Landlord for Landlord’s architects
and engineers to review Tenant’s Plans for consistency of same with the Base Building Work and Landlord Work, if any, which payment to Landlord shall not exceed Two Thousand Five Hundred Dollars ($2,500.00). Tenant’s Plans shall also
include the following: 
 (a)    Final Space Plan: The “Final Space Plan” for the Premises shall
include a full and accurate description of room titles, floor loads, alterations to the Base Building or Landlord Work (if any) or requiring any change or addition to the AS IS condition, and the dimensions and location of all partitions, doors,
aisles, plumbing (and furniture and equipment to the extent same affect floor loading). The Final Space Plan shall (i) be compatible with the design, construction, systems and equipment of the Base Building and Landlord Work, if any:
(ii) specify only materials, equipment and installations which are new and of a grade and quality no less than existing components of the Building when they were originally installed (collectively, (i) and (ii) may be referred to as
“Building Standard” or “Building Standards”): (iii) comply with Laws, (iv) be capable of logical measurement and construction, and (v) contain all such information as may be required for the preparation of the
Mechanical and Electrical Working Drawings and Specifications (including, without limitation, a capacity and usage report, from engineers designated by Landlord pursuant to Section 3.1(b). below, for all mechanical and electrical systems in the
Premises). 
 (b)    Mechanical and Electrical Working Drawings and Specifications: Tenant shall employ engineers
approved by Landlord to prepare Mechanical and Electrical Working Drawings and Specifications showing complete plans for electrical, life safety, automation, plumbing, water, and air cooling, ventilating. heating and temperature control and shall
employ engineers designated by Landlord to prepare for Landlord a capacity and usage report (“Capacity Report”) for all mechanical and electrical systems in the Premises. 

(c)    Issued for Construction Documents: The “Issued for Construction Documents” shall consist of all
drawings (10 scale) and specifications necessary to construct all Premises improvements including, without limitation, architectural and structural working drawings and specifications and Mechanical and Electrical Working Drawings and Specifications
and all applicable governmental authorities plan check corrections. 
 3.2.    Approval by Landlord.
Tenant’s Plans and any, revisions thereof shall be subject to Landlord’s approval, which approval or disapproval: 

(i)    shall not be unreasonably withheld, provided however, that Landlord may disapprove Tenant’s
Plans in its sole and absolute discretion if they (a) adversely affect the structural integrity of the Building, including applicable floor loading capacity; (b) adversely affect any of the Building Systems (as defined below), the Common
Areas or any other tenant space (whether or not currently occupied); (c) fail to fully comply with Laws, (d) affect the exterior appearance of the Building (except for any signage permitted pursuant to other provisions of the Lease): (e)
provide for improvements which do not meet or exceed the Building Standards; or (f) involve any installation on the roof, or otherwise affect the roof, roof membrane or any warranties regarding either. Building Systems collectively shall mean
the structural, electrical, mechanical (including, without limitation, heating, ventilating and air conditioning), plumbing, fire and life-safety (including, without limitation, fire protection system and any fire alarm), communication, utility, gas
(if any), and security (if any) systems in the Building. 

  
 E-3 

 (ii)    shall not be delayed beyond ten (10) business
days with respect to initial submissions and major change orders (those which impact Building Systems or any other item listed in subpart (i) of Section 3.2 above) and beyond five (5) business days with respect to required revisions
and any other change orders. 
 If Landlord disapproves of any of Tenant’s Plans, Landlord shall advise Tenant of what Landlord disapproves in
reasonable detail. After being so advised by Landlord, Tenant shall submit a redesign, incorporating the revisions required by Landlord, for Landlord’s approval. The approval procedure shall be repeated as necessary until Tenant’s Plans
are ultimately approved. Approval by Landlord shall not be deemed to be a representation or warranty by Landlord with respect to the safety, adequacy, correctness, efficiency or compliance with Laws of Tenant’s Plans. Tenant shall be fully and
solely responsible for the safety, adequacy, correctness and efficiency of Tenant’s Plans and for the compliance of Tenant’s Plans with any and all Laws. 

3.3.    Landlord Cooperation. Landlord shall cooperate with Tenant and make good faith efforts to coordinate
Landlord’s construction review procedures to expedite the planning, commencement, progress and completion of Tenant Work. Landlord shall complete its review of each stage of Tenant’s Plans and any revisions thereof and communicate the
results of such review within the time periods set forth in Section 3.2 above. 
 3.4.    City Requirements.
Any changes in Tenant’s Plans which are made in response to requirements of the applicable governmental authorities and/or changes which affect the Base Building Work shall be immediately submitted to Landlord for Landlords review and approval.

 3.5.    “As-Built” Drawings and Specifications. A CADD-DXF file on diskette or CD, pdf versions of the drawings on CD, and a set of “Xerox” type blackline on bond prints of all “as-built” drawings and
specifications of the Premises (reflecting all field changes and including, without limitation, architectural, structural, mechanical and electrical drawings and specifications) prepared by Tenant’s Architect and Engineers or by Contractors
(defined below) shall be delivered by Tenant at Tenant’s expense to the Landlord within thirty (30) days after completion of the Tenant Work. If Landlord has not received such drawings and diskette(s) within thirty (30) days, Landlord
may give Tenant written notice of such failure. If Tenant does not produce such drawings and diskette(s) within ten (10) days after Landlord’s written notice, Landlord may, at Tenant’s sole cost which may be deducted from the
Allowance, produce such drawings and diskette(s) using Landlord’s personnel, managers, and outside consultants and contractors. Landlord shall receive an hourly rate reasonable for such production. 

4.    Tenant Work. 

4.1.    Tenant Work Defined. All tenant improvement work required by the Issued for Construction Documents
(including, without limitation, any approved changes, additions or alterations pursuant to Section 7 below) is referred to in this Workletter as “Tenant Work.” 

4.2.    Tenant to Construct. Tenant shall construct all Tenant Work pursuant to this Workletter, and except to the
extent modified by or inconsistent with express provisions of this Workletter, pursuant with the provisions of the terms and conditions of Article Nine of the Lease, governing Tenant Alterations (except to the extent modified by this Workletter) and
all such Tenant Work shall be considered “Tenant Alterations” for purposes of the Lease. 

4.3.    Construction Contract. All contracts and subcontracts for Tenant Work shall include any terms and
conditions required by Landlord. 
 4.4.    Contractor. Tenant shall select one or more contractors to perform
the Tenant Work (“Contractor”) subject to Landlord’s prior written approval, which shall not unreasonably be withheld. 

4.5.    Division of Landlord Work and Tenant Work. Tenant Work is defined in Section 4.1. above and Landlord
Work, if any, is defined in Section 2. 
 5.    Tenant’s Expense; Allowance. 

Tenant agrees to pay for all Tenant Work, including, without limitation, the costs of design thereof, whether or not all such costs are
included in the “Permanent Improvement Costs” (defined below). Subject to the terms and conditions of this Workletter, Tenant shall apply the “Allowance” (defined below) to payment of the Permanent Improvement Costs. The term
“Permanent Improvement Costs” shall mean the actual and reasonable costs of construction of that Tenant Work which constitutes permanent improvements to the Premises, actual and reasonable 

  
 E-4 

 
costs of design thereof and governmental permits therefor, costs incurred by Landlord for Landlord’s architects and engineers pursuant to Section 3.1, and Landlord’s construction
administration fee (defined in Section 8.10 below). Provided, however, Permanent Improvement Costs shall exclude costs of “Tenant’s FF& E” (defined below). For purposes of this Workletter, “Tenant’s FF& E”
shall mean furniture, furnishings, telephone systems, computer systems, equipment, any other personal property or fixtures, and installation thereof. Landlord shall provide Tenant a tenant improvement allowance (“Allowance”) in the amount
equal to One Hundred Thirteen Thousand Fifty and no/100 Dollars ($113,050.00). The Allowance shall be used solely to reimburse Tenant for the Permanent Improvement Costs. If Tenant does not utilize one hundred percent (100%) of the Allowance for
Permanent Improvement Costs within six (6) months after the Delivery Date of the Premises, Tenant shall have no right to the unused portion of the Allowance. 

6.    Application and Disbursement of the Allowance. 

6.1.    Tenant shall prepare a budget for all Tenant Work, including the Permanent Improvement Costs and all other costs of
the Tenant Work (“Budget), which Budget shall be subject to the reasonable approval of Landlord. Such Budget shall be supported by a guaranteed maximum price construction contract and such other documentation as Landlord may require to evidence
the total costs. To the extent the Budget exceeds the available Allowance (“Excess Cost”), Tenant shall be solely responsible for payment of such Excess Cost. Further, prior to any disbursement of the Allowance by Landlord, Tenant shall
pay and disburse its own funds for all that portion of the Permanent Improvement Costs equal to the sum of (a) the Permanent Improvement Costs in excess of the Allowance; plus (b) the amount of “Landlord’s Retention”
(defined below). “Landlord’s Retention” shall mean an amount equal to fifteen percent (15%) of the Allowance, which Landlord shall retain out of the Allowance and shall not be obligated to disburse unless and until after Tenant has
completed the Tenant Work and complied with Section 6.4 below. Further, Landlord shall not be obligated to make any disbursement of the Allowance unless and until Tenant has provided Landlord with (a) bills and invoices covering all labor
and material expended and used, (b) an affidavit from Tenant stating that all of such bills and invoices have either been paid in full by Tenant or are due and owing, and all such costs qualify as Permanent improvement Costs,
(c) contractors affidavit covering all labor and materials expended and used, (d) Tenant, contractors and architectural completion affidavits (as applicable), and (e) valid mechanics’ lien releases and waivers pertaining to any
completed portion of the Tenant Work which shall be conditional or unconditional, as applicable, all as provided pursuant to Section 6.2 and 6.4 below. 

6.2.    Upon Tenant’s full compliance with the provisions of Section 6, and if Landlord determines that there
are no applicable or claimed stop notices (or any other statutory or equitable liens of anyone performing any of Tenant Work or providing materials for Tenant Work) or actions thereon, Landlord shall disburse the applicable portion of the Allowance
as follows: 
 (a)    In the event of conditional releases, to the respective contractor, subcontractor, vendor, or
other person who has provided labor and/or services in connection with the Tenant Work, upon the following terms and conditions: (i) such costs are included in the Budget, are Permanent Improvement Costs, are covered by the Allowance, and
Tenant has completed and delivered to Landlord a written request for payment, in form reasonably approved by Landlord, setting forth the exact name of the contractor, subcontractor or vendor to whom payment is to be made and the date and amount of
the bill or invoice, (ii) the request for payment is accompanied by the documentation set forth in Section 6.1: and (iii) Landlord, or Landlord’s appointed representative, has inspected and approved the work for which Tenant
seeks payment; or 
 (b)    In the event of unconditional releases, directly to Tenant upon the following terms and
conditions: (i) Tenant seeks reimbursement for costs of Tenant Work which have been paid by Tenant, are included in the Budget, are Permanent Improvement Costs, and are covered by the Allowance: (ii) Tenant has completed and delivered to
Landlord a request for payment, in form reasonably approved by Landlord, setting forth the name of the contractor, subcontractor or vendor paid and the date of payment, (iii) the request for payment is accompanied by the documentation set forth
in Section 6.1: and (iv) Landlord, or Landlord’s appointed representative, has inspected and approved the work for which Tenant seeks reimbursement. 

6.3.    Tenant shall provide Landlord with the aforementioned documents by the 15th of the month and payment shall be made
by the 30th day of the month following the month in which such documentation is provided. 
 6.4.    Prior to Landlord
disbursing the Landlord’s Retention to Tenant, Tenant shall submit to Landlord the following items within thirty (30) days after completion of the Tenant Work: (i) “As Built” drawings and specifications pursuant to
Section 3.5 above, (ii) all unconditional lien releases from all general contractor(s) and subcontractor(s) performing work, (iii) a “Certificate of Completion” prepared by Tenant’s Architect, and (iv) a final
budget with supporting documentation detailing all costs associated with the Permanent Improvement Costs. 

  
 E-5 

 7.    Changes, Additions or Alterations. 

If Tenant desires to make any non-de minimis change, addition or alteration or desires to make any change, addition or
alteration to any of the Building Systems after approval of the Issued for Construction Documents, Tenant shall prepare and submit to Landlord plans and specifications with respect to such change, addition or alteration. Any such change, addition or
alteration shall be subject to Landlord’s approval in accordance with the provisions of Section 3.2 of this Workletter. Tenant shall be responsible for any submission to and plan check and permit requirements of the applicable governmental
authorities. Tenant shall be responsible for payment of the cost of any such change, addition or alteration if it would increase the Budget and Excess Cost previously submitted and approved pursuant to Section 6 above. 

8.    Miscellaneous. 

8.1.    Scope. Except as otherwise set forth in the Lease, this Workletter shall not apply to any space added to the
Premises by Lease option or otherwise. 
 8.2.    Tenant Work shall include (at Tenant’s expense) for all of the
Premises: 
 (a)    Landlord approved lighting sensor controls as necessary to meet applicable Laws: 

(b)    Building Standard fluorescent fixtures in all Building office areas; 

(c)    Building Standard meters for each of electricity and chilled water used by Tenant shall be connected to the
Building’s system and shall be tested and certified prior to Tenant’s occupancy of the Premises by a State certified testing company; 

(d)    Building Standard ceiling systems (including tile and grid) and; 

(e)    Building Standard air conditioning distribution and Building Standard air terminal units. 

8.3.    Sprinklers. Subject to any terms, conditions and limitations set forth herein, Landlord shall provide an operative
sprinkler system consisting of mains, laterals, and heads “AS IS” on the date of delivery of the Premises to Tenant. Tenant shall pay for piping distribution, drops and relocation of, or additional, sprinkler system heads and Building
firehose or firehose valve cabinets, if Tenant’s Plans and/or any applicable Laws necessitate such. 

8.4.    Floor Loading. Floor loading capacity shall be within building design capacity. Tenant may exceed floor
loading capacity with Landlord’s consent, at Landlord’s sole discretion and must, at Tenant’s sole cost and expense, reinforce the floor as required for such excess loading. 

8.5.    Work Stoppages. If any work on the Real Property other than Tenant Work is delayed, stopped or otherwise
affected by construction of Tenant Work, Tenant shall immediately take those actions necessary or desirable to eliminate such delay, stoppage or effect on work on the Real Property other than Tenant Work. 

8.6.    Life Safety. Tenant (or Contractor) shall employ the services of a fire and life-safety subcontractor
reasonably satisfactory to Landlord for all fire and life-safety work at the Building. 
 8.7.    Locks. Tenant
agrees to purchase from Landlord or its representative all cylinders and keys used in locks used in the Premises. 

8.8.    Authorized Representatives. Tenant has designated Peter Van Vlasselaer to act as Tenant’s
representative with respect to the matters set forth in this Workletter. Such representative(s) shall have full authority and responsibility to act on behalf of Tenant as required in this Workletter. Tenant may add or delete authorized
representatives upon five (5) business days notice to Landlord. 
 8.9.    Access to Premises. After
Landlord has recovered possession of the Premises from any prior Tenant, prior to delivery of possession to Tenant upon mutual execution of this Lease, Tenant and its architects, engineers, consultants, and contractors shall have access at
reasonable times and upon advance notice and coordination with the Building management, to the Premises for the purpose of planning Tenant Work and the installation of Tenant’s FF& E. Such access shall not in any manner interfere with
Landlord Work, if any. Such access, and all acts and omissions in connection with it, shall be subject to and governed by all other provisions of 

  
 E-6 

 
the Lease, including, without limitation, Tenant’s indemnification obligations, insurance obligations, etc, except for the payment of Base Rent and Additional Rent. To the extent that such
access by Tenant delays the Substantial Completion of the Landlord Work (if any), such delay shall be a Tenant Delay and the Landlord Work shall be deemed Substantially Complete on the date such Landlord Work would have been completed but for such
access. 
 8.10.    Fee. Landlord shall receive a fee equal to two percent (2.0%) of Tenant’s construction
contract for all costs, including, without limitation, materials, labor, supervision, profit, overhead or general conditions in connection with the construction of the Tenant Work. Such fee is in addition to Tenant’s reimbursement of costs
incurred by Landlord pursuant to other provisions hereof, including, without limitation, for Landlord’s architects and engineers to review Tenant’s Plans. 

9.    Force and Effect. 

The terms and conditions of this Workletter shall be construed to be a part of the Lease and shall be deemed incorporated in the Lease by this reference.
Should any inconsistency arise between this Workletter and the Lease as to the specific matters which are the subject of this Workletter, the terms and conditions of this Workletter shall control. 

  
 E-7 

 EXHIBIT “C” 

SITE PLAN OF PROJECT 
 Phase III, its
buildings and square footages are not a part of the Project as defined in this Lease, and are shown in this Exhibit for illustration only. 
  

 

  
 E-8 

			
	 TENANT CHEMICAL INVENTORY
	  	MetLife Real Estate Investments – Attn: Regional Architect
	 Seaport Centre – Redwood City CA

Rev 5/24/07
  
	  	 425 Market St., #1050, San Francisco, CA 94105 (415)
536-1074
 Fax: 536-1098

		
	Tenant/Company Name: ARMO Biosciences                        	  	Address: 575 Chesapeake Drive, Redwood City, CA 94063      
	Contact Name: John Mumm                                
                   	  	Telephone:
650 267-0338                                
                            

 PLEASE CHECK BELOW: 

1. No:  ☐ or Yes  ☐: (if ‘No’, do not proceed further) 

Do you use and/or store hazardous materials beyond typical household cleaning products? 

2. No:  ☐ or Yes  ☒: 

Have you, or do you plan to submit a ‘Hazardous Materials Business Plan? (San Mateo OES Form 2370) to the San Mateo County Environmental Health Services
Division? 
 3. Please fill out the following for your list of chemicals (See OES Form 2731 for definitions and number
references):     
  

													
	 Common Name

*(207)
	  	 Chemical Name

*(205)
	  	 Physical

State

(Sol/Liq/Gas)

*(214)
	  	 Single

Largest
 Container

*(215)
	  	 Average

Daily
 Amount

*(217)
	  	 Max

Storage
 Amount

*(218)
	  	 Location(s) Stored:
(Interior,
Exterior-
existing shed, Exterior-
proposed shed, Other)

	Liquid Nitrogen	  	Nitrogen CAS # 7727-37-9	  	Gas	  	20L	  	10mls	  	200mls	  	Interior
							
	Sodium Cyanoborohydride in tetrahydrofuran	  	Sodium cyanoborohydride solution CAS# 25895-60-7	  	Liquid	  	100 mls	  	31mls	  	100mls	  	Interior
							
	Ammonium sulfate	  	Ammonium sulfate CAS# 7783-20-2	  	Solid	  	1KG	  	10 gms	  	1KG	  	Interior
							
	Acetic Acid	  	Acetic Acid CAS#64-19-7	  	Liquid	  	2L	  	10mls	  	200mls	  	Interior
							
	Methanol	  	Methanol CAS#67-56-l	  	Liquid	  	2L	  	10mls	  	200mls	  	Interior
							
	Ethanol	  	Ethanol CAS#64-17-5	  	Liquid	  	2L	  	10mls	  	200mls	  	Interior
							
	Toluene	  	Methylbenzene CAS#108-88-3	  	Liquid	  	2L	  	10mls	  	200mls	  	Interior
							
	Acetonitrile	  	Acetonitrile CAS#75-05-8	  	Liquid	  	2L	  	10mls	  	200mls	  	Interior
							
	DTT	  	(2S,3S)-1, 4bis(sulfanyl)butane-2,3-diol CAS#3483-12-3	  	Solid	  	100gms	  	31gm	  	10gms	  	Interior
							
	Tetracycline	  	(4S,6S, 12aS)-4-(dimethylamino)- 1,4,4a,5,5a,6,11,12a-octahydro- 3,6,10,12,12a-pentahydroxy-6-
methyl-1,11-dioxonaphthacene-2-carboxamide CAS#60-54-8	  	Solid	  	100gms	  	31gm	  	10gms	  	Interior

  

											
	For Property Management Use:	 	
						
	☐	  	Received Emergency Response Plan	  	Date Rec’d:	 	  
	  	Comments:	 	  

	☐	  	Received Hazardous Materials Business Plan	  	Date Rec’d:	 	  
	  	Comments:	 	  

	☐	  	Received Annual HazMat Certifications	  	Date Rec’d:	 	  
	  	Comments:	 	  

  
 E-9 

			
	 TENANT CHEMICAL INVENTORY

Seaport Centre – Redwood City CA

Rev 5/24/07
	  	 MetLife Real Estate Investments – Attn: Regional Architect

425 Market St., #1050, San Francisco, CA 94105 (415) 536-1074

Fax: 536-1098

  

													
	Neomycin	  	(2S,3S,4S,5R)-5-amino-2-
(aminomethyl)-6-((2R,3S,4R,5S)-
5-((1R,2R,5R,6R)-3,5-diamino-2- ((2R,3S,4R,5S)-3-amino-6-(aminomethyl)-4,5- dihydroxytetrahydro-2H-pyran-2-
yloxy)-6-hydroxycyclohexyloxy)-4-hydroxy-2- (hydroxymethyl)tetrahydrofuran- 3-yloxy)tetrahydro-2H-pyran-3,4-diol CAS#1404-0402	  	Solid	  	100gms	  	31gm	  	10gms	  	Interior
							
	Ampicillin	  	(2S,5R,6R)-6-([(2R)-2-amino-2-phenylacetyl]amino)
-3,3-dimethyl-7-oxo-4-thia-l- azabicyclo[3.2.0]heptane-2-carboxylic acid CAS#69-53-4	  	Solid	  	100gms	  	31gm	  	10gms	  	Interior
							
	Ethidium Bromide	  	3,8-Diamino-5-ethyl-6-
phenylphenanthridinium bromide CAS#1239-45-8	  	Solid	  	100gms	  	31gm	  	10gms	  	Interior
							
	Hydrochloric Acid	  	Hydrochloric Acid CAS#7647-01-0	  	Liquid	  	500mls	  	10mls	  	100mls	  	Interior
							
	Sodium Hydroxide	  	Sodium Hydroxide CAS#1310-73-2	  	Liquid	  	100mls	  	5mls	  	50mls	  	Interior
							
	Sodium Hydroxide	  	Sodium Hydroxide CAS#1310-73-2	  	Solid	  	500gms	  	5gms	  	50gms	  	Interior
							
	Glutaraldehyde	  	Pentane-1,5-dial CAS#111-30-8	  	Liquid	  	1L	  	100mls	  	500mls	  	Interior
							
	Formaldehyde	  	Methanal CAS#50-00-0	  	Gas	  	(In Formalin NBF) 5L	  	100mls	  	500mls	  	Interior
							
	Hydroquinone	  	Benzene-1,4-diol CAS#123-31-9	  	Solid	  	100gms	  	5gms	  	50gms	  	Interior
							
	Isopropyl Alchohol	  	Isopropyl alcohol CAS# 67-63-0	  	Liquid	  	2L	  	10mls	  	500mls	  	Interior
							
	Periodic Acid	  	Periodic acid CAS#10450-60-9	  	Liquid	  	500mls	  	5mls	  	50mls	  	Interior
							
	Sulphuric Acid	  	Sulphuric Acid CAS#7664-93-9	  	Liquid	  	500mls	  	5mls	  	50mls	  	Interior
							
	Phosphotungstic Acid	  	Phosphotungstic acid CAS#1343-93-7	  	Liquid	  	100mls	  	31mls	  	50mls	  	Interior
							
	Potassium Dichromate	  	Potassium dichromate(VI) CAS#7778-50-9	  	Solid	  	100gms	  	31gms	  	10gms	  	Interior
							
	Potassium Ferricyanide	  	Potassium hexacyanoferrate(III) CAS#13746-66-2	  	Solid	  	500gms	  	31gms	  	10gms	  	Interior
							
	Sodium Azide	  	Sodium Azide CAS#26628-22-8	  	Solid	  	100gms	  	31gms	  	10gms	  	Interior

  

							
	For Property Management Use:	  		  	
				
	☐	  	Received Emergency Response Plan	  	Date Rec’d:                               	  	Comments:                                    
     
	☐	  	Received Hazardous Materials Business Plan	  	Date Rec’d:                               	  	Comments:                                    
     
	☐	  	Received Annual HazMat Certifications	  	Date Rec’d:                               	  	Comments:                                    
     

  
 E-10 

			
	 TENANT CHEMICAL INVENTORY

Seaport Centre – Redwood City CA

Rev 5/24/07
	  	 MetLife Real Estate Investments – Attn: Regional Architect

425 Market St., #1050, San Francisco, CA 94105 (415) 536-1074

Fax: 536-1098

  

													
	Potassium Hydroxide	  	Potassium hydroxide CAS# 1310- 58-3	  	Solid	  	500gms	  	10gms	  	50gms	  	Interior
							
	Potassium Iodide	  	Potassium Iodide CAS#7681-11-0	  	Solid	  	500gms	  	5gms	  	50gms	  	Interior
							
	Schiffs Reagent	  	Sodium Metabisulfite CAS#7681-57-4 Hydrogen Chloride CAS# 7647-01-0
Basic fuchsin CAS#569-61-9	  	Mixture	  	500mls	  	310mls	  	50mls	  	Interior
							
	Silver Nitrate	  	Nitric acid silver(1+) salt CAS#776l-88-8	  	Solid	  	100gms	  	31gms	  	5gms	  	Interior
							
	Acetone	  	Acetone CAS#67-64-l	  	Liquid	  	1L	  	10mls	  	100mls	  	Interior
							
	Dimethy Sulfoxide	  	Dimethyl sulfoxide CAS#67-68-5	  	Liquid	  	500mls	  	5mls	  	50mls	  	Interior
							
	Glutathione	  	(2S)-2-amino-4-{[(1R)-1-
[(carboxymethyl)carbamoyl]-2- sulfanylethyl]carbamoyl} butanoic acid CAS#70-18-8	  	Solid	  	100gms	  	31gms	  	5gms	  	Interior
							
	Sulfur dioxide	  	Sulfurous anhydride Sulfur (IV) oxide CAS#7446-09-5	  	Solid	  	100gms	  	31gms	  	5gms	  	Interior
							
	 Potassium
 Permanganate
	  	Potassium manganite(VII) CAS#7722-64-7	  	Solid	  	500gms	  	31gms	  	10gms	  	Interior
							
	Hydrogen Peroxide	  	Dihydrogen dioxide CAS#7722-84-1	  	Liquid	  	500mls	  	31mls	  	10mls	  	Interior
							
	Guanidine HCL	  	Carbamimidoylazanium chloride CAS#50-01-1	  	Solid	  	2KGs	  	100gms	  	500gms	  	Interior
							
	Ferric Citrate	  	Ferric Citrate CAS#2338-05-8	  	Solid	  	1KG	  	10gms	  	500gms	  	Interior
							
	Acetate	  	Sodium Acetate CAS#127-09-3	  	Solid	  	500gms	  	31gms	  	10gms	  	Interior
							
	HEPES	  	2-[4-(2-hydroxyethyl)piperazin-l-yl]ethanesulfonic acid CAS#7365-45-9	  	Solid	  	1KG	  	10gms	  	250gms	  	Interior
							
	MOPS	  	3-morpholinopropane-1-sulfonic acid CAS#1132-61-2	  	Solid	  	1KG	  	10gms	  	250gms	  	Interior
							
	Potassium Chloride	  	Potassium Chloride CAS#7447-40-7	  	Solid	  	500gms	  	31gms	  	100gms	  	Interior
							
	Magnesium Chloride	  	Magnesium chloride CAS#7786-30-3	  	Solid	  	500gms	  	31gms	  	100gms	  	Interior
							
	SDS	  	Sodium Lauryl Sulfate	  	Solid	  	500gms	  	31gms	  	100gms	  	Interior
							
	Triton X100	  	polyethylene glycol p-(1,1,3,3-tetramethylbutyl)-phenyl ether
CAS#9002-93-1	  	Liquid	  	1L	  	31mls	  	10mls	  	Interior

  

											
	For Property Management Use:	 	
						
	☐	  	Received Emergency Response Plan	  	Date Rec’d:	 	  
	  	Comments:	 	  

	☐	  	Received Hazardous Materials Business Plan	  	Date Rec’d:	 	  
	  	Comments:	 	  

	☐	  	Received Annual HazMat Certifications	  	Date Rec’d:	 	  
	  	Comments:	 	  

  
 E-11 

			
	 TENANT CHEMICAL INVENTORY

Seaport Centre – Redwood City CA

Rev 5/24/07
	  	 MetLife Real Estate Investments – Attn: Regional Architect

425 Market St., #1050, San Francisco, CA 94105 (415) 536-1074

Fax: 536-1098

  

													
	Tween 20	  	Polyoxyethylene (20) sorbitan monolaurate CAS#9005-64-5	  	Liquid	  	500mls	  	31mls	  	10mls	  	Interior
							
	Urea	  	Urea CAS#57-13-6	  	Solid	  	2KG	  	100gms	  	500gms	  	Interior
							
	BME	  	2-Sulfanylethan-I-ol
CAS#60-24-2	  	Liquid	  	500mls	  	31mls	  	10mls	  	Interior
							
	TCEP	  	 3,3’,3”-
 Phosphanetriyltripropanoic
acid CAS#5961-85-3
	  	Liquid	  	1L	  	10mls	  	100mls	  	Interior
							
	TCA	  	Trichloroacetic acid CAS#76-03-9	  	Liquid	  	1L	  	10mls	  	100mls	  	Interior
							
	TFA	  	2,2,2-Trifluoroethanoic acid CAS#76-05-l	  	Liquid	  	1L	  	10mls	  	100mls	  	Interior
							
	Formic Acid	  	Formic Acid CAS#64-18-6	  	Liquid	  	500mls	  	1mls	  	100mls	  	Interior
							
	Sinapinic acid	  	
3-(4-hydroxy-3,5-
 dimeth
 oxyphenyl)prop-2-enoic acid CAS#530-59-6
	  	Liquid	  	500mls	  	1mls	  	50mls	  	Interior
							
	TMB	  	3,3’,5,5’-tetramethylbiphenyl-4,4’- diamine CAS#54827-17-7	  	Solid	  	500gms	  	31gms	  	10gms	  	Interior
							
	Glycerol	  	propane-1,2,3-triol CAS#56-81-5	  	Liquid	  	2L	  	10mls	  	100mls	  	Interior
							
	(3-nitrobenzyl)mercaptan	  	(3-nitrobenzyl)mercaptan CAS#77472-39-0	  	Solid	  	500gms	  	1gms	  	10gms	  	Interior
							
		  	Butanol CAS#71-36-3	  	Liquid	  	500mls	  	5mls	  	50mls	  	Interior
							
	1-methylpiperazine	  	1-methylpiperazine CAS#109-01-3	  	Solid	  	100gms	  	3lgms	  	10gms	  	Interior
							
	2-aminopyridine	  	2-aminopyridine CAS#540-29-0	  	Solid	  	500gms	  	1gm	  	50gms	  	Interior
							
	4-methylumbellifeylacetate	  	 4methylumbellifeylacetate
 CAS#2747-05-9
	  	Solid	  	250gms	  	10gms	  	50gms	  	Interior
							
	Ammonium acetate	  	Ammonium acetateCAS#631-61-8	  	Solid	  	1KG	  	10gms	  	200gms	  	Interior
							
	Ammonium bicarbonate	  	Ammonium bicarbonate CAS#1006-33-7	  	Solid	  	1KG	  	5gms	  	200gms	  	Interior
							
	Ammonium molybdate	  	Ammonium molybdate CAS#12054-85-2	  	Solid	  	100gms	  	3lgms	  	10gms	  	Interior
							
	Anthranilic acid	  	Anthranilic acid CAS#118-92-3	  	Solid	  	100gms	  	3lgms	  	10gms	  	Interior
							
	Boric Acid	  	Boric acid CAS#10043-35-3	  	Solid	  	100gms	  	3lgms	  	10gms	  	Interior

  

											
	For Property Management Use:	 	
						
	☐	  	Received Emergency Response Plan	  	Date Rec’d:	 	  
	  	Comments:	 	  

	☐	  	Received Hazardous Materials Business Plan	  	Date Rec’d:	 	  
	  	Comments:	 	  

	☐	  	Received Annual HazMat Certifications	  	Date Rec’d:	 	  
	  	Comments:	 	  

  
 E-12 

			
	 TENANT CHEMICAL INVENTORY
	  	MetLife Real Estate Investments – Attn: Regional Architect
	 Seaport Centre – Redwood City CA

Rev 5/24/07
	  	 425 Market St., #1050, San Francisco, CA 94105 (415) 536-1074

Fax: 536-1098

  

													
	D-mannitol	  	D-mannitol CAS#69-65-8	  	Solid	  	500gms	  	10gms	  	100gms	  	Interior
							
	Dimethyl Ammonium Dimethyl Carbamate	  	Dimethyl ammonium dimethyl carbamate CAS#4l37-10-4	  	Solid	  	500gms	  	1gms	  	50gms	  	Interior
							
	Hexanes	  	Hexanes CAS#110-54-3	  	Liquid	  	1L	  	10mls	  	100mls	  	Interior
							
	 Malachite Green
 Oxalate Salt
	  	 4-[(4-

dimethylaminophenyl)phenyl-

methyl]-N,N-dimethylaniline

CAS#2437-29-8
	  	Solid	  	100gms	  	1gm	  	25gms	  	Interior
							
	N-butyl chloride	  	1-chlorobutane, N-Butyl chloride CAS# 109-69-3	  	Solid	  	500gms	  	10gms	  	50gms	  	Interior
							
	 N,N-Dimethyl-p-

Phenylenediamine
	  	 N,n-dimethyl-p-

phenylenediamine CAS#536-46-9
	  	Solid	  	25gms	  	31gms	  	5gms	  	Interior
							
	N,N-dimethylformamide	  	N,n-dimethylformamide CAS#68-12-2	  	Liquid	  	500mls	  	10mls	  	50mls	  	Interior
							
	 Phenylisothiocyanate in
 N-Heptane
	  	Isothiocyanatobenzene CAS#103-72-0	  	Liquid	  	100mls	  	10mls	  	25mls	  	Interior
							
	Phosphoric Acid	  	trihydroxidooxidophosphorus phosphoric acid CAS#7664-38-2	  	Liquid	  	100mls	  	1ml	  	25mls	  	Interior
							
	PIPES	  	1,4-Piperazinediethanesulfonic acid CAS#5625-37-6	  	Solid	  	1KG	  	10gms	  	100gms	  	Interior
							
	PEG	  	Polyethylene Glycol CAS#25322-68-3	  	Solid	  	500gms	  	10gms	  	50gms	  	Interior
							
	Polyvinyl Pyrrolidone	  	 Polyvinyl-pyrrolidone
 CAS#9003-39-8
	  	Solid	  	100gms	  	1gm	  	25gms	  	Interior
							
	TRIS(Hydroxymethyl) Aminomethane	  	2-amino-2-(hydroxymethyl)-l,3-
propanediol CAS#77-86-l	  	Solid	  	1KG	  	10gms	  	100gms	  	Interior

  

	*	For reference to Item number in OES Form 2731 

  

 
  

											
	For Property Management Use:	 	
						
	☐	  	Received Emergency Response Plan	  	Date Rec’d:	 	  
	  	Comments:	 	  

	☐	  	Received Hazardous Materials Business Plan	  	Date Rec’d:	 	  
	  	Comments:	 	  

	☐	  	Received Annual HazMat Certifications	  	Date Rec’d:	 	  
	  	Comments:	 	  

  
 E-13 

 EXHIBIT E 

FAIR MARKET RENTAL RATE 

1.    Definition of Fair Market Rental Rate. “Fair Market Rental Rate” shall mean the Monthly Base Rent equal to
the monthly base rental per rentable square foot which a tenant would pay and which a willing landlord would accept for space comparable to the Premises in the Building and in other buildings of class A standards Seaport Centre and along the Highway
101 corridor in Redwood City, Redwood Shores, San Carlos and Belmont (the “Applicable Market”) for the period for which such rental is to be paid and for a lease on terms substantially similar to those of the Lease (including, without
limitation, those applicable to Taxes, Operating Expenses and exclusions, but also considering so-called net and triple net leases, and leases utilizing operating expense stops or base years, and making
appropriate adjustment between such leases and this Lease, as described below), based on prevailing market conditions in the Applicable Market at the time such determination is made (“Comparable Transactions”). Without limiting the
generality of the foregoing, Comparable Transactions shall be for a term similar to the term of tenancy and for space comparable in use, floor levels, view and orientation, square footage and location within the Building and in the Applicable Market
as the transaction for which Fair Market Rental Rate is being determined; however, leases of unusual or odd shaped spaces shall not be considered. In any determination of Fair Market Rental Rate, the stated or contract monthly net or base rental in
Comparable Transactions shall be appropriately adjusted to take into account the different terms and conditions prevailing in such transactions and those present in the Lease, including, without limitation: (a) the extent to which average
annual expenses and taxes per rentable square foot payable by tenants in Comparable Transactions vary from those payable by Tenant under the Lease, and so, for example, if the Lease provides for payment of Rent Adjustments and/or certain Operating
Expenses on the basis of increases over a base year, then the rate of Monthly Base Rent under the Lease shall be based upon a step-up to change the calendar year which serves as the base year for calculation
of the base for such Operating Expenses for the Option Term to be the full calendar year in which the Option Term commences, and such step-up shall be considered in the determination of the Fair Market Rental
Rate; (b) tenant improvements, value of existing tenant improvements, the concessions, if any, being given by landlords in Comparable Transactions, such as parking charge abatement, free rent or rental abatement applicable after substantial
completion of any tenant improvements (and no adjustment shall be made for any free or abated rent during any construction periods), loans at below-market interest rates, moving allowances, space planning allowances, lease takeover payments and work
allowances, as compared to any tenant improvement, refurbishment or repainting allowance given to Tenant under the Lease for the space for which Fair Market Rental Rate is being determined; (c) the brokerage commissions, fees and bonuses
payable by landlords in Comparable Transactions (whether to tenant’s agent, such landlord or any person or entity affiliated with such landlord), as compared to any such amounts payable by Landlord to the broker(s) identified with respect to
the transaction for which Fair Market Rental Rate is being determined; (d) the time value of money; (e) any material difference between the definition of rentable area and the ratio of project rentable to useable square feet in Comparable
Transactions, as compared to such figures applicable to the space for which Fair Market Rental Rate is being determined; and (f) the extent to which charges for parking by tenants in Comparable Transactions vary from those payable by Tenant
under the Lease. 
 2.    Sealed Estimates. In the event the Lease requires Fair Market Rental Rate to be determined in
accordance with this Exhibit, Landlord and Tenant shall meet within ten (10) business days thereafter and each simultaneously submit to the other in a sealed envelope its good faith estimate of Fair Market Rental Rate (the
“Estimates”). If the higher Estimate is not more than one hundred five percent (105%) of the lower Estimate, then Fair Market Rental Rate shall be the average of the two Estimates. If such simultaneous submission of Estimates does not
occur within such ten (10) business day period, then either party may by notice to the other designate any reasonable time within five (5) business days thereafter and any reasonable place at or near the Building for such meeting to take
place. In the event only one party submits an Estimate at that meeting, such Estimate shall be Fair Market Rental. In the event neither party submits an Estimate at that meeting, the transaction for which Fair Market Rental Rate is being determined
shall be deemed cancelled and of no further force or effect. 
 3.    Selection of Arbitrators. If the higher Estimate
is more than one hundred five percent (105%) of the lower Estimate, then either Landlord or Tenant may, by written notice to the other within five (5) business days after delivery of Estimates at the meeting, require that the disagreement be
resolved by arbitration. In the event neither party gives such notice, the transaction for which Fair Market Rental Rate is being determined shall be deemed cancelled and of no further force or effect. Within five (5) business days after such
notice, the parties shall select as arbitrators three (3) mutually acceptable independent MAI appraisers with experience in real estate activities, including at least five (5) years experience in appraising comparable space in the
Applicable Market (“Qualified Appraisers”). If the parties cannot timely agree on such arbitrators, then within the following five (5) business days, each shall select and inform the other party of one (1) Qualified Appraiser and
within a third period of five (5) business days, the two appraisers (or if only one (1) has been duly selected, such single appraiser) shall select as 

  
 E-14 

 
arbitrators a panel of three additional Qualified Appraisers, which three arbitrators shall proceed to determine Fair Market Rental Rate pursuant to Section 4 of this Exhibit. Both Landlord
and Tenant shall be entitled to present evidence supporting their respective positions to the panel of three arbitrators. 

4.    Arbitration Procedure. Once a panel of arbitrators has been selected as provided above, then as soon thereafter as
practicable each arbitrator shall select one of the two Estimates as the one which, in its opinion, is closer to Fair Market Rental Rate. Upon an Estimate’s selection by two (2) of the arbitrators, it shall be the applicable Fair Market
Rental Rate and such selection shall be binding upon Landlord and Tenant. If the arbitrators collectively determine that expert advice is reasonably necessary to assist them in determining Fair Market Rental Rate, then they may retain one or more
qualified persons, including but not limited to legal counsel, brokers, architects or engineers, to provide such expert advice. The party whose Estimate is not chosen by the arbitrators shall pay the costs of the arbitrators and any experts retained
by the arbitrators. Any fees of any counsel or expert engaged directly by Landlord or Tenant, however, shall be borne by the party retaining such counsel or expert. 

5.    Rent Pending Determination of Fair Market Rental Rate. In the event that the determination of Fair Market Rental
Rate has not been concluded prior to commencement of the applicable rental period for the applicable space for which the Fair Market Rental Rate is being determined, Tenant shall pay Landlord Monthly Base Rent and Rent Adjustment Deposits as would
apply under Landlord’s Estimate pursuant to Section 2 of this Exhibit until the Fair Market Rental Rate is determined. In the event that the Fair Market Rental Rate subsequently determined is different from the amount paid for the
applicable period, then within thirty (30) days after such determination, Tenant shall pay Landlord any greater amounts due and Landlord shall credit Tenant (against the next Monthly Base Rent installments due) for any reduction in the amounts
due. 

  
 E-15 

 

 

  
 E-16 

 

 

  
 E-17 

 RIDER 1 

COMMENCEMENT DATE AGREEMENT 
 METROPOLITAN LIFE
INSURANCE COMPANY, a New York corporation (“Landlord”), and ARMO BIOSCIENCES, INC., a Delaware corporation (“Tenant”), have entered into a certain Lease dated May 19, 2013 (the “Lease”). 

WHEREAS, Landlord and Tenant wish to confirm and memorialize the Commencement Date and Expiration Date of the Lease as provided for in Section 2.02(b) of
the Lease; 
 NOW, THEREFORE, in consideration of the foregoing and the mutual covenants contained herein and in the Lease, Landlord and Tenant agree as
follows: 
 1.    Unless otherwise defined herein, all capitalized terms shall have the same meaning ascribed to them in
the Lease. 
 2.    The Commencement Date (as defined in the Lease) of the Lease is 5/19/13. 

3.    The Expiration Date (as defined in the Lease) of the Lease is 5/18/17. 

4.    Tenant hereby confirms the following: 

(a)    That it has accepted possession of the Premises pursuant to the terms of the Lease; 

(b)    That the Landlord Work, if any, is Substantially Complete; and 

(c)    That the Lease is in full force and effect. 

(5)    Except as expressly modified hereby, all terms and provisions of the Lease are hereby ratified and confirmed and
shall remain in full force and effect and binding on the parties hereto. 
 (6)    The Lease and this Commencement Date
Agreement contain all of the terms, covenants, conditions and agreements between the Landlord and the Tenant relating to the subject matter herein. No prior other agreements or understandings pertaining to such matters are valid or of any force and
effect. 
 IN WITNESS WHEREOF, Landlord and Tenant have executed this Commencement Date Agreement and such execution and delivery have been
duly authorized. 
  

									
	 TENANT
	 		 	LANDLORD
			
	ARMO BIOSCIENCES, INC.,	 		 	METROPOLITAN LIFE INSURANCE COMPANY,
		 		 		 	a New York corporation

									
					
	By:	 	 /s/ Peter Van Vlasselaer
	 		 	By:	 	 /s/ Greg Hill

		 	Peter Van Vlasselaer	 		 		 	Greg Hill
		 	Print Name	 		 		 	Print Name

									
					
	Its:	 	 CEO
	 		 	Its:	 	 Director

		 	Chairman of the Board, President or Vice President)	 		 		 	
					
	By:	 	 /s/ Marcia Hatch
	 		 		 	
		 	Marcia Hatch	 		 		 	
		 	Print Name	 		 		 	
					
	Its:	 	 Asst. Secretary
	 		 		 	
		 	(Secretary, Assistant Secretary, CFO or Assistant Treasurer)	 	

  
 E-18 

 RIDER 2 

ADDITIONAL PROVISIONS 
 This Rider
2 (“Rider”) is attached to and a part of a certain Lease by METROPOLITAN LIFE INSURANCE COMPANY, a New York corporation, as Landlord, and ARMO BIOSCIENCES, INC., a Delaware corporation (for purposes of this Rider, “ARMO”), as
Tenant, for the Premises as described therein (the “Lease”). 
 SECTION 1. DEFINED TERMS; FORCE AND EFFECT 

Capitalized terms used in this Rider shall have the same meanings set forth in the Lease except as otherwise specified herein and except for terms capitalized
in the ordinary course of punctuation. This Rider forms a part of the Lease. Should any inconsistency arise between this Rider and any other provision of the Lease as to the specific matters which are the subject of this Rider, the terms and
conditions of this Rider shall control. 
 SECTION 2. CONDITION OF PREMISES; DELIVERY; CONSTRUCTION PERIOD; COMMENCEMENT DATE: TERM 

2.1.    Projected Delivery Date. Delivery Date: Commencement Date: Tenant’s Obligations During, Construction
Period’ Term. 
 (a)    Landlord shall tender to Tenant possession of the Premises in the condition specified in
the Workletter within a reasonable time after the Lease has been executed by both Tenant and Landlord (the “Projected Delivery Date”). On the date Landlord actually tenders to Tenant possession of the Premises (the “Delivery
Date”), all the terms and conditions of the Lease shall apply, and Tenant shall observe and perform all terms and conditions of the Lease, including all that are specified to apply during the Term (for example only, Tenant’s insurance and
indemnification obligations), except that during the period (the “Construction Period”) from the Delivery Date until the Commencement Date (defined below), in recognition of Tenant’s construction and installations in, and preparation
of, the Premises for the use and occupancy permitted by this Lease: (i) Tenant shall not be obligated to pay Monthly Base Rent, Rent Adjustment Deposits or Rent Adjustments; and (ii) Landlord shall not be obligated to provide services or
utilities except if and to the extent expressly provided in Section 4 of the Workletter. The Term of this Lease shall be as shown in Section 1.01(5) of the Basic Lease Provisions and the Commencement Date of the Term shall be the date
which is the earlier to occur of (i) Substantial Completion of the Tenant Work, or (ii) ninety (90) days after mutual execution of this Lease. 

(b)    Upon request by Landlord, Tenant and Landlord shall enter into an agreement (the form of which is attached to this
Lease as Rider 1) confirming the Commencement Date and the Expiration Date. If Tenant fails to enter into such agreement within five (5) business days after Landlord’s request enclosing the proposed agreement, then the Commencement Date
and the Expiration Date shall be the dates designated by Landlord in such agreement. 
 2.2    Failure to Deliver
Possession. If Landlord shall be unable to give possession of the Premises on the Projected Delivery Date by reason of the following: (i) the holding over or retention of possession of any tenant, tenants or occupants, or (ii) the
Landlord Work, if any, is not Substantially Complete, or (iii) for any other reason, then Landlord shall not be subject to any liability for the failure to give possession on said date. Under such circumstances, by operation of Section 2.1
above and/or the definition of the Commencement Date, the Delivery Date and Commencement Date are automatically adjusted and determined in relation to the date Landlord actually tenders possession of the Premises to Tenant. No such failure to
deliver possession on the originally scheduled Projected Delivery Date shall affect the validity of this Lease or the obligations of the Tenant hereunder. If Rider 2 or the Workletter requires that any Landlord Work or Tenant Work or both be
Substantially Complete as an element of determining when the Delivery Date or Commencement Date occurs, then such work shall be deemed Substantially Complete if the delay in achieving actual Substantial Completion shall be due to any Tenant Delay
and/or default on the part of Tenant. In the event of any dispute as to whether the applicable work is Substantially Complete, the decision of Landlord’s architect shall be final and binding on the parties. 

SECTION 3. TEMPORARY SPACE. 
 Tenant has requested Temporary
Space (defined below) in order to allow Tenant to vacate space it occupies in another property and move to the Building pending availability of the Premises and the construction of Tenant Work therein. Landlord is willing to provide Temporary Space
as provided below. “Temporary Space” shall mean the space as outlined on Exhibit G to this Lease, which space is located at 505 Penobscot Drive and shall consist of up to 6,000 square feet of Rentable Area. Tenant
may lease from Landlord the Temporary Space at any time during the period starting on the date this Lease (and Tenant has paid Landlord all advance Monthly Base Rent, Rent Adjustment 

  
 E-19 

 
Deposit, Management Fee and Security Deposit funds due from Tenant pursuant to this Lease) has been signed by Tenant and signed by Landlord, and continuing through the ‘Temporary Space
Expiration Date” (defined below). As used herein, the ‘Temporary Space Expiration Date” shall be the end of the third (3rd) day after the date the Tenant Work in the Premises is Substantially Complete. Upon Tenant’s written
notice to Landlord that Tenant elects to lease the Temporary Space, Landlord shall lease to and Tenant shall lease from Landlord the Temporary Space commencing on the date specified in Tenant’s notice and continuing through the Temporary Space
Expiration Date. Neither Landlord nor Landlord’s agents have made any representations or promises with respect to the Temporary Space except as herein expressly set forth. Tenant hereby acknowledges and agrees that it accepts the Temporary
Space in its “AS-IS” condition, and that the Temporary Space is in satisfactory condition and in the condition in which Landlord is obligated to deliver it without any obligation of Landlord to
repaint, remodel, improve or alter it or to provide Tenant any allowance therefor. The Temporary Space shall be deemed to be an additional part of the Premises, and the lease of the Temporary Space shall be subject to all of the terms, covenants and
conditions of this Lease, including the obligation to pay for any additional or after hours services provided to Tenant, and Tenant shall be obligated to pay its pro rata share of Rent Adjustment Deposits and Rent Adjustment with respect to the
Temporary Space based upon the number of square feet of Rentable Area of the Temporary Space to the Rentable Area of 505 Penobscot Drive, Phase II and Project; provided, however, Tenant shall not be obligated to pay Landlord Monthly Base Rent with
respect to the Temporary Space for the first ninety (90) days following the mutual execution of this Lease. Commencing upon the Commencement Date of this Lease, should Tenant remain in occupancy of the Temporary Space, Tenant shall be obligated
to pay Landlord Monthly Base Rent with respect to the Temporary Space in the amount of Eleven Thousand Seven Hundred and 68/100 Dollars ($11,700.68), which rate shall be effective through Month 12 of the Term of this Lease. Should the Temporary
Space Expiration Date occur after the end of Month 12 of the Term of this lease, Tenant shall pay Landlord Monthly Base Rent with respect to the Temporary Space at the same rates as are in effect for Premises under the Lease for the duration of the
Term. Tenant shall vacate and surrender the Temporary Space no later than the Temporary Space Expiration Date and otherwise pursuant to Article Twelve of this Lease, and if Tenant holds over in all or any part of such space thereafter, such holdover
shall be upon and subject to all of the terms, covenants and conditions of this Lease, including Article Thirteen, except that the rate for both Monthly Base Rent and Rent Adjustments payable by Tenant with respect to the Temporary Space (in
addition to Rent payable for the Premises) during any holding over shall be Twenty-Three Thousand Four Dollars ($23,401.36) per month. During the term of the lease of the Temporary Space and until the Commencement Date of the Lease of the Premises,
Tenant shall be entitled to use the number and type of Parking Spaces at the rates and as otherwise provided in Section 1.01(18) and Section 2.06 of the Lease. 

SECTION 4. OPTION TO EXTEND. 

(a)    Landlord hereby grants Tenant a single option to extend the Term of the Lease for an additional period of three
(3) years (such period may be referred to as the “Option Term”), as to the entire Premises as it then exists, upon and subject to the terms and conditions of this Section (the “Option To Extend”), and provided that at the
time of exercise of such option (and each Option, if more than one Option is granted): (i) Tenant must be conducting regular, active, ongoing business in, and be in occupancy (and occupancy by a subtenant, licensee or other party permitted or
suffered by Tenant shall not satisfy such condition, except a Permitted Transferee that satisfies the terms and conditions of Sections 10.01 and 10.05 of the Lease) of the entire Premises; and (ii) there has been no material adverse change in
Tenant’s financial position from such position as of the date of execution of the Lease, as certified by Tenant’s independent certified public accountants, and as supported by Tenant’s certified financial statements, copies of which
shall be delivered to Landlord with Tenant’s written notice exercising its right hereunder. Without limiting the generality of the foregoing, Landlord may reasonably conclude there has been a material adverse change if Tenant’s independent
certified public accountants do not certify there has been no such change. 
 (b)    Tenant’s election (the
“Election Notice”) to exercise the Option To Extend must be given to Landlord in writing no earlier than the date which is twelve (12) months prior to the Expiration Date and no later than the date which is nine (9) months prior
to the Expiration Date. If Tenant either fails or elects not to exercise the Option to Extend by not timely giving its Election Notice, then the Option to Extend shall be null and void, including, if more than one Option is granted, the then
applicable Option to Extend and all further Options to Extend. 
 (c)    The Option Term (and each Option Term, if more
than one Option is granted) shall commence immediately after the expiration of the preceding Term of the Lease. Tenant’s leasing of the Premises during the Option Term shall be upon and subject to the same terms and conditions contained in the
Lease except that (i) Tenant shall pay the “Option Term Rent”, defined and determined in the manner set forth in the immediately following Subsection; (ii) the Security Deposit shall be increased to an amount that is the same
percentage or proportion of Option Term Rent as the prior amount of Security Deposit was in relation to Rent for the Term prior to the Option Term, but in no event shall the Security Deposit be decreased; and (iii) Tenant shall accept the
Premises in its “as is” condition without any obligation of Landlord to repaint, remodel, repair, improve or alter the Premises or to provide 

  
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Tenant any allowance therefor, except to the extent tenants leasing space in Comparable Transactions receive an allowance pursuant to the definition of Fair Market Rental Rate defined in
Exhibit E hereto, provided, however, Landlord by notice given to Tenant within thirty (30) days after final determination of the Fair Market Rental Rate, may elect to provide, in lieu of such allowance for alterations
to the Premises, a rent credit equal to the amount of the allowance that would have otherwise been given, credited toward the rents applicable only to the Premises and due starting after such rent obligation commences. If Tenant timely and properly
exercises the Option To Extend, references in the Lease to the Term shall be deemed to mean the preceding Term as extended by the Option Term unless the context clearly requires otherwise. 

(d)    The Option Term Rent shall mean the sum of the Monthly Base Rent at the Fair Market Rental Rate (as defined in
Exhibit E) plus Rent Adjustments and/or certain Operating Expenses (if applicable, based upon a step-up to change the base year or base amount for calculation of Operating Expenses in
connection with determination of the Fair Market Rental Rate) plus other charges pursuant to the Lease payable to Landlord. The determination of Fair Market Rental Rate and Option Term Rent shall be made by Landlord, in the good faith exercise of
Landlord’s business judgment. Within forty-five (45) days after Tenant’s exercise of the Option To Extend, Landlord shall notify Tenant of Landlord’s determination of the Fair Market Rental Rate and Option Term Rent for the
Premises. Tenant may, within fifteen (15) days after receipt thereof, deliver to Landlord a written notice either: (i) accepting Landlord’s determination, in which case the extension shall be effective and binding (subject to
Subsection ) below) at the accepted rate; or (ii) setting forth Tenant’s good faith estimate, in which case Landlord and Tenant will promptly confer and attempt to agree upon the Fair Market Rental Rate and Option Term Rent. Tenant’s
failure to timely deliver such notice within such fifteen (15) day period shall be deemed its cancellation of the Option. In the event Tenant has delivered notice setting forth Tenant’s different estimate, but no agreement in writing
between Tenant and Landlord on Fair Market Rental Rate and Option Term Rent is reached within thirty (30) days after Landlord’s receipt of Tenant’s estimate, the Fair Market Rental Rate shall be determined in accordance with the terms
of Exhibit E. To the extent that Tenant pays directly the utility or service provider for utilities or services which Tenant is to obtain directly pursuant to the Lease, Tenant shall continue to pay such amounts, but such
amounts shall not be counted as part of the Fair Market Rental Rate as used herein. 
 (e)    Promptly after final
determination of the Fair Market Rental Rate, Landlord shall prepare a memorandum confirming the specific dates, amounts and terms of the extension for the Option Term in accordance with the terms and conditions of this Option to Extend, in the form
of an amendment to the Lease, and Tenant shall execute such amendment within five (5) business days after Landlord and Tenant agree to the form of the proposed amendment and Landlord shall execute it promptly after Tenant. Notwithstanding any
of the foregoing to the contrary, the failure of Landlord to prepare such amendment or of either party to execute an amendment shall not affect the validity and effectiveness of the extension for the Option Term in accordance with the terms and
conditions of this Option to Extend. 
 (f)    Upon the occurrence of any of the following events, Landlord shall have
the option, exercisable at any time prior to commencement of the Option Term, to terminate all of the provisions of this Section with respect to the Option to Extend, whereupon any prior or subsequent exercise of this Option to Extend shall be of no
force or effect: 
 (i)    Tenants failure to timely exercise or timely to perform the Option to Extend in strict
accordance with the provisions of this Section. 
 (ii)    The existence at the time Tenant exercises the Option to
Extend or at the commencement of the Option Term of a Default on the part of Tenant under the Lease or of any state of facts which with the passage of time or the giving of notice, or both, would constitute such a Default. 

(iii)    Tenant’s third Default under the Lease prior to the commencement of the Option Term, notwithstanding that all
such Defaults may subsequently be cured. 
 (g)    Without limiting the generality of any provision of the Lease, time
shall be of the essence with respect to all of the provisions of this Section. 
 (h)    This Option to Extend is
personal to ARMO and may not be used by, and shall not be transferable or assignable (voluntarily or involuntarily) to any person or entity other than a Permitted Transferee which is an assignee of the Lease and which has satisfied the requirements
of Sections 10.01 and 10.05 of this Lease, and such Permitted Transferee may exercise the right without Tenant joining in or consenting to such exercise, and notwithstanding anything to the contrary, Tenant shall remain liable for all obligations
under the Lease, including those resulting from any such exercise with the same force and effect as if Tenant had joined in such exercise. 

  
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 SECTION 5. TENANT SIGNAGE & EXTERIOR SIGNAGE 

(a)    Signage Generally. Except as expressly provided herein, Tenant shall not install any signage within the
Project, the Building or the Premises (if visible from the exterior of the Premises) without obtaining the prior written approval of Landlord, and Tenant shall be responsible for procurement, installation, maintenance and removal of any such signage
installed by Tenant, and all necessary repairs and restoration to the Premises and the Building, and all costs in connection therewith. Any such signage shall comply with Landlord’s current Building signage standards, any applicable recorded
covenants, conditions and restrictions, and all Laws, and shall be consistent with class A standards. 

(b)    Exterior Sign Right. 

(1)    Grant of Right. Only for so long as: (i) Tenant leases, is continuously conducting regular, active,
ongoing business in, and is in occupancy of the entire Premises ; and Tenant is not a bank, investment bank, stock broker, insurance company or other financial institution, and Tenant’s business does not in material part include any of the
foregoing businesses (collectively, the “Exterior Sign Conditions”), Tenant shall have the right to place (A) Tenant identification on one (1) line of the existing, exterior monument sign located on Chesapeake Drive as more
particularly described in Exhibit F attached hereto, and (B) Tenant’s sign or logo on the exterior glass of the Premises near the main entrance to the Premises (collectively, the “Exterior Building
Sign”), subject to the terms, covenants and conditions set forth in this Subsection (b) (“Exterior Sign Right”). Nothing contained herein shall prohibit or limit Landlord in granting any other exterior signage rights to others. 

(2)    General Conditions & Requirements. The Exterior Sign Right is subject to the
following conditions and requirements: (i) the Exterior Building Sign shall not cover or obstruct any window area, (ii) Tenant shall obtain all necessary approvals for the Exterior Building Sign under, and shall comply with, all applicable
laws, rules and regulations of applicable governmental authorities (including, without limitation, any applicable airport or Federal Aviation Administration authorities) and all recorded covenants, conditions and/or restrictions which apply to the
Building; (iii) the size, type, style, materials and colors of the sign, method of installation and specific location of the sign, and the contractor for and all work in connection with the sign, contemplated by this Exterior Sign Right shall
be subject to Landlord’s prior written approval, which approval shall not be unreasonably withheld: (iv) the name on the Exterior Building Sign shall be subject to the prior written approval of Landlord, which approval shall not be
unreasonably withheld; (v) the Exterior Building Sign shall be consistent with the design of the Building; (vi) the Exterior Building Sign shall be procured, installed, operated, maintained and repaired in safe and good condition, and in
class A appearance, by Tenant, at its sole cost and expense, and Tenant shall maintain the areas on which the sign is mounted watertight and shall not adversely affect the good appearance of the areas on which the sign is mounted; (vii) to the
extent permitted by law, Tenant assumes all risk of defacement, damage, theft, loss and destruction of Tenant’s Exterior Building Sign due to any cause, including but not limited to, casualty, vandalism or any act or neglect of any other
tenant, guest or occupant of the Project or any member of the public, and Landlord shall not be liable for any of the foregoing or obligated to carry insurance covering any of the foregoing; (viii) if lighting is approved, Tenant shall, at its
sole cost and expense, arrange for electrical service and electrical connections for lighting the sign, including separate meter or submeter for electricity use in connection with the Exterior Building Sign; and (ix) prior to commencement of
any work, Tenant shall deliver to Landlord certificates of insurance evidencing that Tenant’s contractors, agents, workmen, engineers or other persons installing the Building Sign have in effect valid workers’ compensation, public
liability and builder’s risk insurance in amounts and with such companies and in such forms as Landlord considers necessary or appropriate for its protection. Tenant agrees that Landlord shall have the right to temporarily remove and replace
the Exterior Building Sign in connection with and during the course of any repairs, changes, alterations, modifications, renovations or additions to the Building. 

(3)    Expiration or Termination: Removal & Restoration. If Tenant fails to meet and comply
with the Exterior Sign Conditions set forth above, or if there exists a Default by Tenant with respect to any of the general conditions and requirements of Subsection (2) above or any other provisions of the Lease, then in any such event, the
Exterior Sign Right shall terminate. Upon the expiration or termination of the Exterior Sign Right, but in no event later than the expiration of the Term or earlier termination of the Lease, Tenant shall, at its sole cost and expense, remove such
sign and shall repair and restore the area in which the sign was located to its condition prior to installation of such sign. Tenant shall complete all removal, repair and restoration with respect to the Exterior Building Sign no later than thirty
(30) days after such expiration or termination, and in the event that Tenant’s Exterior Sign Right shall terminate as provided in the first sentence of this Subsection (3) and Landlord shall require Tenant to remove such sign, Tenant
shall, within thirty (30) days after written notice from Landlord, and at Tenant’s sole cost and expense, remove such sign and shall repair and restore the area in which the sign was located to its condition prior to installation of such
sign. In the event that Tenant fails timely to remove and restore as provided above, Landlord may, but shall not be obligated to, remove the Exterior Building Sign and restore the affected area at Tenant’s sole cost and expense. 

  
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 (4)    Advance Notice: No Liens. Tenant shall keep the Building and
Project free of all liens with respect to all work and materials performed and provided in connection with such sign, and Tenant shall give Landlord at least ten (10) days prior written notice of the intended commencement of work in connection
with the Exterior Building Sign. 
 (5)    Right Personal. The Exterior Sign Right is personal to ARMO and may
not be used by, and shall not be transferable or assignable (voluntarily or involuntarily) to any person or entity other than a Permitted Transferee which is an assignee of the Lease and which has satisfied the requirements of Sections 10.01 and
10.05 of this Lease. 

  
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