Document:

EX-10.21

 Exhibit 10.21 

PERSONAL LINES CUT-THROUGH 

QUOTA SHARE REINSURANCE AGREEMENT 

BY AND AMONG 
 TOWER
INSURANCE COMPANY OF NEW YORK, 
 CASTLE POINT NATIONAL INSURANCE COMPANY, 

TOWER NATIONAL INSURANCE COMPANY, 

HERMITAGE INSURANCE COMPANY, 

CASTLE POINT FLORIDA INSURANCE COMPANY, 

KODIAK INSURANCE COMPANY, 

NORTH EAST INSURANCE COMPANY, 

YORK INSURANCE COMPANY OF MAINE, 

MASSACHUSETTS HOMELAND INSURANCE COMPANY, 

PRESERVER INSURANCE COMPANY 

AND 
 CASTLE POINT
INSURANCE COMPANY, 
 as Ceding Companies, 

AND 
 INTEGON NATIONAL
INSURANCE COMPANY, 
 as Reinsurer 

 TABLE OF CONTENTS 

 

							
	 ARTICLE 1 DEFINITIONS
	  	 	1	  
	 Section 1.1.
	  	 Defined Terms
	  	 	1	  
		
	 ARTICLE 2 BASIS OF REINSURANCE AND BUSINESS REINSURED
	  	 	6	  
	 Section 2.1.
	  	 Underwriting of Subject Policies
	  	 	6	  
	 Section 2.2.
	  	 Insurance Contracts
	  	 	7	  
		
	 ARTICLE 3 PAYMENTS, OFFSET, AND SECURITY
	  	 	7	  
	 Section 3.1.
	  	 Premium
	  	 	7	  
	 Section 3.2.
	  	 Offset Rights
	  	 	9	  
	 Section 3.3.
	  	 Premiums for Insurance Contracts
	  	 	9	  
	 Section 3.4.
	  	 Reports and Remittances
	  	 	10	  
	 Section 3.5.
	  	 Collateral for Ceded Losses
	  	 	13	  
		
	 ARTICLE 4 CLAIMS, UNDERWRITING AND OTHER ADMINISTRATION
	  	 	13	  
		
	 ARTICLE 5 REGULATORY MATTERS
	  	 	15	  
		
	 ARTICLE 6 DUTY OF COOPERATION & INDEMNITY; REINSURANCE; MGA
	  	 	16	  
	 Section 6.1.
	  	 Cooperation
	  	 	16	  
	 Section 6.2.
	  	 Indemnity
	  	 	16	  
	 Section 6.3.
	  	 Reinsurance
	  	 	16	  
	 Section 6.4.
	  	 Substitution of Managing General Agency
	  	 	16	  
		
	 ARTICLE 7 INSOLVENCY
	  	 	16	  
		
	 ARTICLE 8 REGULATORY APPROVALS
	  	 	17	  
		
	 ARTICLE 9 DURATION
	  	 	17	  
		
	 ARTICLE 10 FOLLOW THE FORTUNES
	  	 	18	  
		
	 ARTICLE 11 INDEMNIFICATION
	  	 	18	  
	 Section 11.1.
	  	 Indemnification
	  	 	18	  
		
	 ARTICLE 12 MISCELLANEOUS
	  	 	19	  
	 Section 12.1.
	  	 Notices
	  	 	19	  
	 Section 12.2.
	  	 Assignment; Parties in Interest
	  	 	20	  
	 Section 12.3.
	  	 Waivers and Amendments; Preservation of Remedies
	  	 	21	  
	 Section 12.4.
	  	 Governing Law; Venue
	  	 	21	  
	 Section 12.5.
	  	 Counterparts
	  	 	21	  
	 Section 12.6.
	  	 Entire Agreement; Merger
	  	 	21	  
	 Section 12.7.
	  	 Exhibits and Schedules
	  	 	21	  
	 Section 12.8.
	  	 Headings
	  	 	21	  
	 Section 12.9.
	  	 Severability
	  	 	21	  

							
	 Section 12.10.
	  	 Expenses
	  	 	22	  
	 Section 12.11.
	  	 Currency
	  	 	22	  
	 Section 12.12.
	  	 Separate Agreements
	  	 	22	  

 PERSONAL LINES CUT-THROUGH 

QUOTA SHARE REINSURANCE AGREEMENT 

THIS PERSONAL LINES CUT-THROUGH QUOTA SHARE REINSURANCE AGREEMENT (this “Agreement”) is entered into as of January 3,
2014 by and among TOWER INSURANCE COMPANY OF NEW YORK, an insurance company organized under the laws of New York, CASTLE POINT NATIONAL INSURANCE COMPANY, an insurance company organized under the laws of Illinois, TOWER NATIONAL INSURANCE COMPANY,
an insurance company organized under the laws of Massachusetts, HERMITAGE INSURANCE COMPANY, an insurance company organized under the laws of New York, CASTLE POINT FLORIDA INSURANCE COMPANY, an insurance company organized under the laws of Florida,
KODIAK INSURANCE COMPANY, an insurance company organized under the laws of New Jersey, NORTH EAST INSURANCE COMPANY, an insurance company organized under the laws of Maine, YORK INSURANCE COMPANY OF MAINE, an insurance company organized under the
laws of Maine, MASSACHUSETTS HOMELAND INSURANCE COMPANY, an insurance company organized under the laws of Massachusetts, PRESERVER INSURANCE COMPANY, an insurance company organized under the laws of New Jersey, and CASTLE POINT INSURANCE COMPANY, an
insurance company organized under the laws of New York (the “Ceding Companies” and, each a “Ceding Company”), and INTEGON NATIONAL INSURANCE COMPANY, an insurance company organized under the laws of North Carolina
(the “Reinsurer”) (collectively, the “Parties”). 
 WHEREAS, this Agreement is being entered into
in connection with that certain Merger Agreement of even date herewith by and between Tower Group International, Ltd. (“Tower”), ACP Re. Ltd. (“ACP Re”) and Merger Sub (the “Merger Agreement”)
whereby Merger Sub is merging with and into Tower with Tower surviving such merger and related transactions by which National General Holdings Corporation shall acquire the renewal rights to all of Tower’s Personal Lines Business (as defined
herein); 
 WHEREAS, as more particularly set forth herein, the Ceding Companies and the Reinsurer wish to enter into a quota share
arrangement pursuant to which the Reinsurer will reinsure (i) all Losses with respect to the Subject Policies written by the Ceding Companies in accordance with the terms hereof on or after the Effective Time and (ii) Losses occurring on
or after the Effective Time with respect to the Included Existing Contracts. 
 NOW, THEREFORE, in consideration of the mutual and
several promises and undertakings herein contained, and for other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged, the Parties agree as follows: 

Article 1 

DEFINITIONS 

Section 1.1 Defined Terms. 

The following terms shall have the respective meanings specified below throughout this Agreement. 

 “ACP Re” has the meaning set forth in the Recitals. 

“Actual UPR Transfer Amount” has the meaning set forth in Section 3.1(a)(iii). 

“Agreement” has the meaning set forth in the first paragraph. 

“Affiliate” (and, with a correlative meaning, “Affiliated”) means, with respect to any Person, any other Person that
directly, or indirectly through one or more intermediaries, controls, or is controlled by, or is under common control with, such first Person. As used in this definition, “control” (including, with correlative meanings, “controlled
by” and “under common control with”) shall mean possession, directly or indirectly, of power to direct or cause the direction of management or policies (whether through ownership of securities or partnership or other ownership
interests, by contract, as trustee or executor, or otherwise). 
 “Alternative Accountants” has the meaning set forth in
Section 3.1(a)(iv). 
 “Applicable Law” means any applicable order, law, statute, regulation, rule, pronouncement, ordinance,
bulletin, writ, injunction, directive, judgment, decree, principle of common law, constitution or treaty enacted, promulgated, issued, enforced or entered by any Governmental Authority applicable to the parties hereto, or any of their respective
businesses, properties or assets. 
 “Ceding Commission” means amounts payable to the Ceding Companies by the Reinsurer equal to:

 (a) the Commission Percentage of Premiums collected by or remitted to the Reinsurer following the Effective Time, settled
up as between the Parties as part of the monthly reporting pursuant to Section 3.4; 
 (b) with respect to the Unearned
Premium Reserve, the Commission Percentage of the Unearned Premium Reserves transferred on the UPR Transfer Date, payable as follows: 

(i) on the UPR Transfer Date, the Initial UPR Ceding Commission; and 

(ii) following determination of the final Actual UPR Transfer Amount, as determined pursuant to Section 3.1(a)(iv) below,
if such final Actual UPR Transfer Amount is greater than the Initial UPR Transfer Amount, the the Commission Percentage of the UPR Adjustment, payable following receipt of the UPR Adjustment Amount from the Ceding Companies; and 

(c) the Claims Service Expenses incurred by the Ceding Companies during the term of this Agreement with respect to the
Insurance Contracts, not to exceed 4.00% of the sum of Premiums collected following the Effective Time and the Unearned Premium Reserves transferred to the Reinsurer as of the UPR Transfer Date, after giving effect to the UPR Adjustment, settled up
as between the Parties as part of the monthly reporting pursuant to Section 3.4. 

  
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 “Claim” and “Claims” means any and all claims, requests, demands or notices
made by or on behalf of policyholders, beneficiaries or third party claimants for the payment of Losses and any other amounts due or alleged to be due under or in connection with the Insurance Contracts. 

“Claims Service Expenses” means unallocated loss adjustment expenses incurred by the Ceding Company in servicing the Claims under or
covered by the Insurance Contracts and/or coverage actions under or covered by the Insurance Contracts including, but not limited, to, salaries and expenses of claims department employees and office and other overhead expenses. 

“Closing Date” means the date hereof. 

“Commission Percentage” means (a) twenty percent (20%), or (b) in the event the Merger Agreement is terminated by ACP Re
other than for a material breach of the Merger Agreement by Tower, twenty-five percent (25%), with any increase in the Commission Percentage taking effect as to Ceding Commissions with respect to Premiums written on or after such termination. 

“Cut-Through Endorsement” means an endorsement in the form of Exhibit B attached hereto. 

“Damages” means all damages, losses, liabilities and expenses (including reasonable attorneys’ fees and reasonable expenses of
investigation in connection with any action, suit or proceeding). 
 “Effective Time” means 12:01 a.m. Eastern Time on
January 1, 2014. 
 “Estimated Exising Contract UPR” has the meaning set forth in Section 3.1(a)(ii). 

“Excluded Contracts” means such insurance contracts, policies, certificates, binders, slips, covers or other agreements of insurance
as set forth or described on a schedule (the “Excluded Contract Schedule”) that will be provided by the Reinsurer to Tower on or before the end of the UPR Review Period. 

“Excluded Contract Schedule” has the meaning set forth in the definition of “Excluded Contracts”. 

“Existing Contracts” means all insurance contracts, policies, certificates, binders, slips, covers or other agreements of insurance,
including all supplements, riders and endorsements issued or written in connection therewith and extensions thereto, as to the Personal Lines Business, in-force as of the Effective Time, issued, renewed, or written by or on behalf of the Company
prior to the Effective Time. 
 “Governmental Authority” means any foreign, domestic, federal, territorial, state or local U.S. or
non-U.S. governmental authority, quasi-governmental authority, instrumentality, court or government, self-regulatory organization, commission, tribunal or organization or any political or other subdivision, department, branch or representative of
any of the foregoing. 

  
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 “Included Existing Contracts” means the Existing Contracts, except for the Excluded
Contracts. 
 “Initial UPR Ceding Commission” means the Commission Percentage of the Initial UPR Transfer Amount. 

“Initial UPR Transfer Amount” has the meaning set forth in Section 3.1(a)(ii). 

“Insurance Contracts” means the Included Existing Contracts and the Subject Policies. 

“Inuring Reinsurance” means all reinsurance agreements, treaties and contracts (other than this Agreement) entered into by the
Ceding Companies with respect to the Insurance Contracts to the extent that such reinsurance agreements, treaties and contracts provide reinsurance coverage for the Insurance Contracts. 

“Inuring Reinsurance Costs” means any ceded premium or premium deposit paid or payable by a Ceding Company for Inuring Reinsurance.

 “Loss Adjustment Expenses” means expenses incurred by or on behalf of the a Ceding Company to Persons not Affiliates of any
Ceding Company or employees thereof related to the investigation, appraisal, adjustment, litigation, defense or appeal of Claims under or covered by the Insurance Contracts and/or coverage actions under or covered by the Insurance Contracts but not
including the Ceding Companies’ overhead, however the Ceding Company’s expenses and costs for the employed attorneys and other legal personnel of the Ceding Company or its affiliates when engaged in the defense of claims under or covered
by the Insurance Contracts and/or coverage actions under or covered by the Insurance Contracts shall be included as Loss Adjustment Expenses. 

“Loss Fund Account” means a separate bank account described in Article 4(h) and the Loss Fund Account Procedures. 

“Loss Fund Account Procedures” shall mean those procedures attached as Exhibit D hereto. 

“Losses” shall mean (i) liabilities and obligations to make payments to policyholders, beneficiaries and/or other third party
claimants under the Insurance Contracts excluding, for avoidance of doubt, liabilities or assessments arising from a Ceding Company’s participation, if any, in any voluntary or involuntary pools, guaranty funds, or other types of
government-sponsored or government-organized insurance funds); (ii) all Loss Adjustment Expenses including, without limitation, in each instance (A) all liabilities for consequential, exemplary, punitive or similar extra contractual
damages, or for statutory or regulatory fines or penalties, or for any loss in excess of the limits arising under or covered by any Insurance Contract, and (B) court costs accrued prior to final judgment, prejudgment interest or delayed damages
and interest accrued after final judgment and (iii) all Claims Servicing Expenses. Notwithstanding the foregoing, “Losses” shall not include any liabilities or obligations incurred by or on behalf of a Ceding Company (x) as a
result of any grossly negligent, willful, fraudulent and/or criminal act by the Ceding Company or any of its Affiliates or any of their respective officers, directors, employees or agents following the Effective Time, or (y) under an Existing
Policy for a Loss 

  
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occurring prior to the Effective Time. Losses shall be net of all Inuring Reinsurance paid or payable to or for the benefit of a Ceding Company, whether or not collected by the Ceding Company.

 “Merger Agreement” has the meaning set forth in the Recitals. 

“Merger Sub” means the subsidiary of ACP Re that will merge with Tower pursuant to the Merger Agreement. 

“MGA Agreement” has the meaning set forth in Section 6.4. 

“Parties” has the meaning set forth in the first paragraph. 

“Person” shall mean any individual, corporation, partnership, firm, joint venture, association, joint-stock company, limited
liability company, trust, estate, unincorporated organization, Government Authority or other entity. 
 “Personal Lines Business”
means all insurance contracts, policies, certificates, binders, slips, covers or other agreements of insurance, including all supplements, riders, endorsements, renewals and extensions for personal automobile liability and personal physical damage,
homeowners, personal excess and personal umbrella coverage issued by the Ceding Companies. 
 “Premium(s)” means all gross written
premium(s), considerations, deposits, premium adjustments, fees and similar amounts related to the Insurance Contracts, less cancellation and return premiums. 

“Premium Bordereaux” has the meaning set forth in Section 3.4. 

“Reinsurer” has the meaning set forth in the first paragraph. 

“Subject Policies” means all insurance contracts, policies, certificates, binders, slips, covers or other agreements of insurance,
including all supplements, riders, endorsements, renewals and extensions as to the Personal Lines Business issued by the Ceding Companies or any Ceding Company following the Effective Time pursuant to the Underwriting Guidelines or pursuant to
written consent of the Reinsurer. 
 “Taxes” (or “Tax” as the context may require) means all United States federal,
state, county, local, foreign and other taxes (including, without limitation, income taxes, payroll and employee withholding taxes, unemployment insurance, social security taxes, premium taxes, excise taxes, sales taxes, use taxes, gross receipts
taxes, franchise taxes, ad valorem taxes, severance taxes, capital property taxes and import duties), and includes interest, additions to tax and penalties with respect thereto, whether disputed or not. 

“Tower” has the meaning set forth in the Recitals. 

“Underwriting Guidelines” means the underwriting and eligibility guidelines and procedures in effect as of the date hereof, without
any change unless consented to in writing by the Reinsurer. On and after the date hereof, upon at least five (5) days written notice to Tower, 

  
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the Reinsurer may make such changes to the Underwriting Guidelines as it shall determine in its sole discretion; provided that no such change shall require the Ceding Companies to issue a new
product or to change their existing commission structure. 
 “Unearned Acquisition Costs” means an amount equal to the actual
out-of-pocket expenses incurred by the Ceding Companies, attributable solely to the unearned portion of Premiums paid or payable prior to, on or after the Effective Time on the Included Existing Contracts, to persons who are not Affiliates of the
Ceding Companies to acquire the Included Existing Contracts, including all commissions and brokerage payments and any adjustments thereto. 

“Unearned In-Force Inuring Reinsurance Costs” means an amount equal to the unearned portion (calculated using the daily pro
rata method) of any premium or premium deposit paid or payable by the Ceding Companies prior to, on or after the Effective Time for Inuring Reinsurance attributable to the Included Existing Contracts that shall not have been paid by the Reinsurer or
one of its Affiliates. 
 “Unearned Premium Reserves” means the gross liability as of the Effective Time for the amount of
collected Premium corresponding to the unexpired portion of all Included Existing Contracts, less the corresponding Unearned Acquisition Costs and Unearned In-Force Inuring Reinsurance Costs on such collected Premium, in each case calculated using
the daily pro rata method in a manner consistent with the Ceding Companies’ quarterly financial statements dated as of September 30, 2013, prepared in accordance with statutory accounting practices and subject to any applicable Premium,
commission or brokerage adjustments prior to or after the Effective Time pursuant to the underlying terms and conditions of any Insurance Contract or agent or broker contract related thereto, which adjustments shall be accounted for and settled as
between the Parties as part of the monthly reporting pursuant to Section 3.4. 
 “UPR Review Period” means the period
beginning on the Closing Date and ending on 11:59 p.m. on the tenth business day following the Closing Date. 
 “UPR Transfer
Date” has the meaning set forth in Section 3.1(a)(ii) 
 “UPR True Up Report” has the meaning set forth in
Section 3.1(a)(iii). 
 “UPR Adjustment” has the meaning set forth in Section 3.1(a)(v). 

Article 2 
 BASIS OF
REINSURANCE AND BUSINESS REINSURED 
 Section 2.1 Underwriting of Subject Policies; Identification of Excluded
Contracts. 
 (a) Each Ceding Company agrees that each Subject Policy reinsured hereunder shall be underwritten in all respects in
accordance with the Underwriting Guidelines in effect as of the date of issuance of such Subject Policy or approved in writing by the Reinsurer. 

  
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The Ceding Company shall be entitled to issue a Cut-Through Endorsement (i) on or after the Effective Time, as to each Subject Policy and (ii) following the end of the UPR Review
Period, as to each Existing Contract with respect to Losses occurring after the Effective Time. Any interest of the Ceding Companies in renewal rights and expirations relating to the Insurance Contracts shall be retained by the Ceding Companies.

 (b) During the UPR Review Period, the Ceding Companies shall provide the Reinsurer access to such records, reports and information with
respect to the Unearned Premium Reserve and Existing Contracts for the purpose of determining the Existing Contracts, which are Excluded Contracts. On or before the end of the UPR Review Period, the Reinsurer shall provide the Ceding Companies a
list of Excluded Contracts. 
 Section 2.2 Insurance Contracts. 

(a) From and after the Effective Time, each Ceding Company hereby cedes, and the Reinsurer hereby assumes, one hundred percent (100%) of
all Losses (a) for which such Ceding Company is liable in respect of the Subject Policies, and (b) occurring following the Effective Time for which such Ceding Company is liable in respect of Included Existing Contracts. 

(b) In the event the Reinsurer makes an indemnity payment on behalf of an Ceding Company directly to any policyholder, insured or third party
pursuant to any Insurance Contract that pays, in full or in part, a Loss, cost or expense under such Insurance Contract, such payment satisfies and extinguishes any and all obligation of the Reinsurer hereunder to indemnify a Ceding Company for such
Loss, cost or expense to the extent of such payment. In no event shall the Reinsurer be obligated hereunder to indemnify with respect to any Loss, cost or expense under an Insurance Contract for an amount in excess of such Loss, cost or expense.

 (c) In the event that the unearned premium reserve of the Ceding Companies with respect to the Excluded Contracts is more than forty
percent (40%) of the unearned premium reserve of the Ceding Companies with respect to the Existing Contracts, in each case as of the Effective Time and as reasonably determined by the Ceding Companies in accordance with the definition of
Unearned Premium Reserves, the Ceding Companies may, upon written notice to the Reinsurer delivered within ten (10) business days of Tower’s receipt of the Excluded Contracts Schedule, elect to exclude all Existing Contracts from this
Agreement, in which case there shall be no Included Existing Contracts. 
 Article 3 

PAYMENTS, OFFSET, AND SECURITY 

Section 3.1 Premium. 

(a) Unearned Premium Reserves and Premiums. 

(i) As full premium for the Included Existing Contracts ceded under this Agreement, the Ceding Companies shall transfer to the
Reinsurer (A) all of the Unearned Premium Reserves held by the Company relating to such ceded business, net of Ceding Commission, and (B) all Premiums collected by or on behalf of the Ceding Companies

  
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on account of the Included Existing Contracts on or after the date hereof, to the extent unearned as of the date hereof. 

(ii) Unless an election to exclude Existing Contracts shall have been made pursuant to Section 2.2(c), on the eleventh
(11th) business day following the delivery of the Excluded Contract Schedule (the “UPR Transfer Date”), the Ceding Companies shall remit to the Reinsurer by wire transfer of immediately available funds an amount (the “Initial UPR
Transfer Amount”) equal to the Ceding Companies’ reasonable estimate of the Unearned Premium Reserves for the Included Existing Contracts as of the Effective Time, net of the Initial UPR Ceding Commission and net of uncollected premium
balances due on such Unearned Premium Reserves. 
 (iii) Within ninety (90) days following the UPR Transfer Date, Tower
shall recalculate the amounts specified in Section 3.1(a)(ii) considering the post-UPR Transfer Date information available to the Parties (such calculations resulting in the calculation of the “Actual UPR Transfer Amount”) and,
if different from the Initial UPR Transfer Amount, Tower shall send to the Reinsurer its computation of the Actual UPR Transfer Amount together with its work papers used to compute the same (the “UPR True Up Report”). In the event
of the failure of Tower to deliver the UPR True Up Report within the time period specified herein, the Reinsurer shall be entitled to prepare and deliver to Tower the UPR True Up Report within one hundred eighty (180) days following the UPR
Transfer Date. Tower shall consult with the Reinsurer in the course of preparing the UPR True Up Report and shall afford the Reinsurer and its designees access to the Ceding Companies’ books and records in accordance with Section 3.4(d)
until the final Actual UPR Transfer Amount and the UPR Adjustment are finally determined pursuant to this Section 3.1(a). 

(iv) Within ten (10) days following Tower’s or the Reinsurer’s, as applicable, receipt of the UPR True Up
Report, the Parties shall confer in good faith with regard to the Actual UPR Transfer Amount and, if necessary, an appropriate adjustment shall be made to the amounts due or payable pursuant to this Section 3.1(a) as agreed upon by the Parties.
If the Parties are unable to agree on the Actual UPR Transfer Amount within twenty (20) days of Tower’s receipt of the UPR True Up Report, “Alternative Accountants,” whose decision on the matter shall be binding on the
Parties, shall be designated by agreement between Tower and the Reinsurer. If the Parties fail to agree on the selection of the Alternative Accountants, the Alternative Accountants shall be selected by mutual agreement of each of Tower’s and
the Reinsurer’s outside independent auditors. The Alternative Accountants shall conduct such analysis as they deem appropriate, during a period not to exceed thirty (30) days after they are selected, to determine the amounts which they
conclude should have been reflected in the UPR True Up Report and shall issue their decision (which shall be rendered in writing and shall specify the reasons for the decision) within fifteen (15) days after the conclusion of their analysis.
The Alternative Accountants’ decision shall include a determination of the Actual UPR Transfer Amount, the amounts which they have determined should be used for the UPR True Up Report and a determination of the UPR Adjustment (as that term is
defined in Section 3.1(a)(v)) due to the Reinsurer or the Ceding Companies, as the case may be. Each Party shall make available to the other Party and the Alternative 

  
 - 8 - 

 
Accountants such work papers as may be reasonably necessary to calculate the Actual UPR Transfer Amount and UPR Adjustment under this Section 3.1(a)(iv). No Party shall have any ex
parte discussions or communications, directly or indirectly, with the Alternative Accountants regarding the subject matter of a dispute arising under this Section 3.1(a)(iv), unless the Party seeking such discussions or communications first
obtains the other Party’s written consent to such ex parte contact with the Alternative Accountants. For the avoidance of doubt, in the event of any dispute with respect to the UPR True Up Report, such dispute shall be governed by this
Section 3.1(a)(iv) and the procedures set forth herein, and not by the provisions of Section 12.4. 
 (v) On the
fifth (5th) business day following the mutual written agreement of Tower and the Reinsurer to, or the determination by the Alternative Accountants of, the final Actual UPR Transfer Amount, if
the premium required under this subsection (a) using such final Actual UPR Transfer Amount exceeds the Initial UPR Transfer Amount, the Ceding Companies shall remit funds to the Reinsurer equal to the difference, and if the premium so
calculated is less than the Initial UPR Transfer Amount, the Ceding Companies shall be paid such difference by the Reinsurer, net of the Ceding Commission paid on such difference (the amount so transferred being herein called the “UPR
Adjustment”). 
 (b) Subject Policies. As premium for the Subject Policies ceded under this Agreement, each
Ceding Company shall pay to the Reinsurer one hundred percent (100%) of the Premiums collected that are attributable to the Subject Policies for coverage following the Effective Time, less Inuring Reinsurance Costs. 

(c) Ceding Commission. The Reinsurer shall pay the Ceding Commission with respect to the collected Premium. 

Section 3.2 Offset Rights. 

Each Party shall have, and may exercise at any time and from time to time, the right to offset any balance or balances due to the other
Parties arising under this Agreement, and regardless of whether on account of Losses, Premiums, Ceding Commission or Inuring Reinsurance Costs, related to or arising under the Insurance Contracts; provided, however, that in the event
of the insolvency of a Party hereto or any of its Affiliates, offsets shall only be allowed in accordance with the provisions of Applicable Law. 

Section 3.3 Premiums for Insurance Contracts 

(a) The Reinsurer is authorized to collect Premiums for the Insurance Contracts from policyholders and producers of a Ceding
Company and may deposit such Premiums directly into one or more accounts designated by, and issued in the name of, the Reinsurer. The Ceding Companies shall direct policyholders and producers to make all Premium payments payable with respect to
Insurance Contracts directly to Reinsurer. To the extent any Premiums are collected directly by a Ceding Company, such Ceding Company shall so advise the Reinsurer and shall promptly remit them to the Reinsurer. Provided that the Reinsurer properly
funds the Loss Fund Account in accordance with 

  
 - 9 - 

 
Section 4(h), such remittance shall be without any reduction or offset for any Ceding Commission or Losses due to any Ceding Company or any amount due Tower or any of its Affiliates. The
Reinsurer and the Ceding Companies agree to maintain accounting and operational records and books in adequate detail so as to identify the specific Insurance Contracts and policyholders of the Ceding Companies with respect to all collected Premiums
and to report Premiums collected in accordance with Section 3.4(a). 
 (b) The Reinsurer shall: (i) timely pay any
return premium, coming due under the Insurance Contracts; or (ii) pursuant to the next monthly settlement pursuant to Section 3.4, reimburse a Ceding Company for any of the foregoing amounts that are instead paid by such Ceding Company,
net of the amount of Ceding Commission paid upon any such return premium. Ceding Company shall reimburse the Reinsurer for any Ceding Commission on return premium paid by Reinsurer. 

(c) Notwithstanding the foregoing, the Parties recognize that Premium is remitted to the Ceding Companies by producers net of
commissions due and that in such case only net Premium shall be remitted to the Reinsurer. 
 Section 3.4 Reports and
Remittances. 
 (a) The Parties shall conduct monthly settlements based upon monthly bordereaux to be provided by or
on behalf of the Ceding Companies evidencing the amount due or to be due in a form, and containing such detail, as is agreed to by the Parties. Each Party shall pay or credit in cash or its equivalent to the other all net amounts for which it may be
liable under the terms and conditions of this Agreement within ten (10) days after receipt of each Premium Bordereaux and Inuring Reinsurance report. In connection with such monthly settlement the Ceding Companies shall: 

(i) With regard to the Insurance Contracts and Cut-Through Endorsements, furnish to Reinsurer, in an electronic format the
following: 
 (1) The Ceding Companies will prepare and submit to the Reinsurer a detailed and itemized monthly statement
(the “Premium Bordereaux”) of (a) all Premiums written and Premium adjustments (whether additional or returned), (b) Premiums collected by the Ceding Company, (c) based on information provided by Reinsurer no later than the
10th day of each month (a “Premiums Collection Report”), Premiums collected by Reinsurer, and (c) Ceding Commissions payable, Ceding Commission adjustments and Ceding Commissions paid or collected by the Ceding Companies with respect
to all business and transactions effective in that month no later than the 15th day of the subsequent month; provided that if reasonably required by Reinsurer, Ceding Companies shall provide the information described above and the accounts
receivable aging described in subsection (ii) more frequently than monthly to the extent it is commercially practicable for them to do so. 

  
 - 10 - 

 (2) The Ceding Companies will provide a monthly account current report (the
“Account Current”) to the Company no later than the 15th day of the subsequent month. The Account Current will include the following information on a per Policy basis as of the end of the given month: 

 

	 	a)	Policy Number; 

  

	 	b)	Insured; 

  

	 	c)	Policy Effective Date; 

  

	 	d)	Expiration Date; 

  

	 	e)	Transaction Type; 

  

	 	f)	Written Premium for the month; 

  

	 	g)	Commission respective of the written Premium noted above and payable to agents and producers unaffiliated with the Ceding Companies; 

 

	 	h)	Policy fee payable to persons unaffiliated with the Ceding Companies (if applicable); 

  

	 	i)	Claims paid; 

  

	 	j)	Loss Adjustment Expenses paid; 

  

	 	k)	Surcharges/Tax (if applicable); 

  

	 	l)	Net Amount Due to the Reinsurer; 

  

	 	m)	Outstanding balance owed to the Ceding Companies; and 

  

	 	n)	Installment plan and premium billed (if applicable) 

 (ii) Based upon the
Premium Bordereaux delivered each month, the Ceding Companies will provide the Reinsurer with a monthly accounts receivable aging by Policy with such report to be received by Reinsurer within thirty (30) days of the end of the month for which
the report has been prepared. 
 (iii) The Ceding Companies will provide Reinsurer a monthly report of underwriting activity.
Such report shall include: 
 (1) Total Premium Written; 

(2) Policies issued by named insured, including premium; 

  
 - 11 - 

 (3) Cut-Through Endorsements issued by named insured and policy number; 

(4) A pricing report split by new and renewal business, including all pricing information; and 

(iv) The Ceding Companies will prepare and submit to the Reinsurer a detailed and itemized monthly statement (the “Claims
Bordereaux”) of all required Claims statistical information including, but not limited to, Claims and Loss Adjustment Expenses paid and outstanding reserves no later than the 15th day of the subsequent month. 

(v) The Ceding Companies will prepare and submit to the Reinsurer a detailed and itemized monthly statement of premiums ceded
pursuant to Inuring Reinsurance, outstanding obligations to pay such ceded premium and such ceded premium paid in each case by assuming reinsurer and treaty or agreement relating to the Inuring Reinsurance, including, if Reinsurer shall provide such
information to the Ceding Companies on or before the 10th day of the month, any ceded premium paid by the Reinsurer. 
 From time-to-time upon reasonable
written notice by Reinsurer to the Ceding Companies, Reinsurer may replace, modify or amend the procedures and reporting requirements set forth in (i) through (iv) above in good faith in order to facilitate efficient performance by the
Parties of their respective obligations under this Agreement. 
 (b) The Ceding Companies and the Reinsurer shall furnish
each other with such records, reports and information with respect to the Unearned Premium Reserve, the Actual UPR Transfer Amount, Loss Adjustment Expenses, Losses, Claims and the reinsurance contemplated hereby as may be reasonably required by the
other Party to comply with any internal reporting requirements or reporting requirements of any Governmental Authority, to prepare and complete such Party’s quarterly and annual financial statements or to calculate the final Actual UPR Transfer
Amount and any UPR Adjustment. 
 (c) If any Ceding Company or the Reinsurer receives notice of, or otherwise becomes aware
of, any inquiry, investigation, proceeding, from or at the direction of a Governmental Authority, or is served or threatened with a demand for litigation, arbitration, mediation or any other similar proceeding relating to the Insurance Contracts,
such Ceding Company or the Reinsurer, as applicable, shall promptly notify the other party thereof, whereupon the parties shall cooperate in good faith and use their respective commercially reasonable efforts to resolve such matter in a mutually
satisfactory manner in light of all the relevant business, regulatory and legal facts and circumstances. 
 (d) Each Party
shall have the right, through authorized representatives and upon reasonable advance notice during normal business hours, to periodically audit and inspect all books, records, and papers of the other Party solely in connection with (i) the
Insurance Contracts and any reinsurance hereunder or claims in connection therewith, (ii) the performance of the claims, underwriting and other administration services pursuant to 

  
 - 12 - 

 
Article 4, and (iii) the determination of the Actual UPR Transfer Amount and the UPR Adjustment. All such audits or inspections conducted by Reinsurer through its authorized representatives
shall include claim systems and imaged document access, both on-site and remote. Reinsurer may appoint any Person it deems necessary to conduct such audits or inspections. Each Party shall treat the other Party’s books, records, and papers in
confidence. A Party shall be permitted to conduct such audits relating to subsections (i) and (ii) above no more frequently than semi-annually. 

Section 3.5 Collateral for Ceded Losses. 

Without limiting the Reinsurer’s other obligations under this Section 3.6, in the event pursuant to Applicable Law of any state of
the United States of America or the District of Columbia having jurisdiction over a Ceding Company, such Ceding Company is no longer able to take full reserve credit on its statutory financial statements for the reinsurance ceded to the Reinsurer
without qualifying collateral therefor, the Reinsurer shall promptly agree to modifications to this Agreement so that the Reinsurer shall provide collateral for its obligations hereunder in the amount and form necessary for such Ceding Company to
take full reserve credit on its statutory financial statements for the reinsurance provided hereunder on terms and conditions reasonably satisfactory to such Ceding Company and Reinsurer and in accordance with Applicable Law. 

Article 4 
 CLAIMS,
UNDERWRITING AND OTHER ADMINISTRATION 
 (a) The Reinsurer may, at any time, assume authority from the Ceding
Companies in all matters relating to the administration of the Insurance Contracts and any Claims thereunder, including but not limited to the authority (i) to pay and adjust Claims on behalf of such Ceding Company, (ii) to communicate
directly with policyholders and to collect on behalf of such Ceding Company unpaid Premiums that relate solely to the Insurance Contracts, and (iii) to handle the placement, production, underwriting, service and management of the Insurance
Contracts, including without limitation the authority to (A) solicit, accept and receive submissions for Insurance Contracts or renewals of Insurance Contracts; (B) secure, at its own expense, reasonable underwriting information through
reporting agencies or other appropriate sources relating to each submission; (C) issue, renew and countersign. Insurance Contracts and endorsements related thereto; (D) collect and receipt for the premiums on Insurance Contracts;
(E) calculate and pay producer commissions, countersignature fees, inspection fees, loss prevention expenses, and all other expenses directly related to the production, underwriting and administration of the business subject to this Agreement,
(F) adjust and settle claims under the Insurance Contracts; (G) set and establish loss reserves for the Insurance Contracts; and (H) any and all other acts or duties that would otherwise be performed by such Ceding Company necessary
and appropriate to the Insurance Contracts, to the extent such authority may be granted pursuant to Applicable Law and the Reinsurer, or one or more of the Reinsurer’s Affiliates designated by the Reinsurer, shall perform all such functions as
outlined herein. In exercising such authorities, the Reinsurer or any such Affiliate may delegate the performance of any duty described above to a third party; provided that no such delegation shall relieve the Reinsurer of its obligations
hereunder. Subject to the forgoing limitation, 

  
 - 13 - 

 
effective as of the Effective Time, in furtherance of Reinsurer’s right to assume authority for administration of Insurance Contracts, each Ceding Company hereby appoints the Reinsurer as
its attorney-in-fact with respect to the rights, duties and privileges and obligations of such Ceding Company in and to the Insurance Contracts, with full power and authority to act in the name, place and stead of such Ceding Company with respect to
such contracts, including without limitation, the power to service such contracts, to adjust, defend, settle and to pay all Claims, to recover salvage and subrogation for any losses incurred and to take such other and further actions as may be
necessary or desirable to effect the transactions contemplated by this Agreement, provided, that the Reinsurer covenants to exercise such authority in a professional manner and to use the same level of care as is used in administering the
Reinsurer’s other insurance business. In furtherance of such assumption of authority, each Ceding Company grants full authority to the Reinsurer to adjust, settle or compromise all Losses hereunder, and all such adjustments, settlements and
compromises shall be binding on such Ceding Company. In connection with any such assumption of authority, each Ceding Company agrees to cooperate fully with the Reinsurer in any transfer of administration, and the Reinsurer agrees to be responsible
for such administration. 
 (b) On and after the Effective Time, each Ceding Company will provide prompt notice to the
Reinsurer or its designee of all Claims (i) described on Exhibit C attached hereto, (ii) in excess of policy limits or (iii) that are extra-contractual in nature (but only to the extent such Claims are not otherwise known or reported
to the Reinsurer or any of its Affiliates). 
 (c) A Ceding Company shall not (i) establish any Claim reserve or
(ii) enter into any settlement at or above $100,000 without the written consent of Reinsurer, which shall not be unreasonably denied, delayed or conditioned. 

(d) A Ceding Company shall not issue any coverage declination outside the ordinary course of business to either the named
insured or any party who seeks additional insured coverage under the named insured’s policy, unless supported by a coverage opinions with the adjuster’s notice report and the written consent of Reinsurer, which shall not be unreasonably
denied, delayed or conditioned; provided that upon five (5) days written notice from the Reinsurer to a Ceding Company, the Reinsurer may require that all coverage declinations in the ordinary course of business shall be subject to this
sentence. All other coverage questions must be reviewed and approved by Reinsurer in writing prior to providing any notification to an insured. 

(e) A Ceding Company shall not commence any declaratory judgment action without the prior written consent of Reinsurer, which
shall not be unreasonably denied, delayed or conditioned. 
 (f) Subject to Paragraph (a) of this Article 4, each Ceding
Company or its designated Affiliate will administer, investigate and defend, as applicable, each Claim under any Subject Policy issued by it. At the request of the Reinsurer or such designee, the applicable Ceding Company will jointly associate with
the Reinsurer, at the expense of the Reinsurer, in the defense or control of any Claim, suit or proceeding involving this 

  
 - 14 - 

 
reinsurance, and such Ceding Company shall cooperate with the Reinsurer or such designee in every respect to procure the most favorable disposition of such claim, suit or proceeding. 

(g) The Ceding Companies shall maintain sufficient resources and adequate staffing levels of personnel with appropriate
experience to administer the Insurance Contracts in a professional manner and shall administer the Insurance Contracts in accordance with all Applicable Laws. 

(h) To facilitate the payment of Claims and Loss Adjustment Expenses, the Parties agree to use a Loss Fund Account upon the
terms provided in this Agreement and the Loss Fund Account and Data Reporting Procedures set forth on Exhibit D attached hereto (the “Loss Fund Account Procedures”). From time-to-time upon reasonable written notice by Reinsurer to the
Ceding Companies, Reinsurer may replace, modify or amend the Loss Fund Account Procedures in good faith in order to facilitate efficient performance by the Parties of their respective obligations under this Agreement. The funds deposited into such
account shall at all times remain exclusive property of the Reinsurer. The Loss Fund Account shall be funded exclusively by the Reinsurer. The Ceding Companies shall have no obligation to advance its own funds for the payment of Claims or Loss
Adjustment Expenses. 
 (i) The Ceding Companies shall cancel Policies as to which Premium is overdue pursuant to its
customary practices unless otherwise directed in writing by Reinsurer; provided that any such cancellation shall be in accordance with Applicable Law. 

(j) Reinsurer may assign employees of Reinsurer or one of its Affiliates to the appropriate offices of any Tower Affiliate for
purposes of monitoring claims administration, underwriting of Insurance Contracts and issuance of Cut-Through Endorsements. Tower shall make or cause one of its Affiliates to make space available, including a private office or conference room and,
where provided to employees of Tower Affiliates, adequate parking spaces, to such assigned employees as well as internet and phone access, at no cost to Reinsurer. 

Article 5 

REGULATORY MATTERS 

At all times during the term of this Agreement, the Ceding Companies and the Reinsurer shall hold and maintain all licenses and authorizations
required under Applicable Law and otherwise take all actions that may be necessary to perform its obligations hereunder. 

  
 - 15 - 

 Article 6 

DUTY OF COOPERATION & INDEMNITY; REINSURANCE; MGA 

Section 6.1 Cooperation. 

Each Party hereto shall cooperate fully with the other in all reasonable respects in order to accomplish the objectives of this Agreement.

 Section 6.2 Indemnity 

This Agreement is an agreement for indemnity reinsurance solely between the Ceding Companies and the Reinsurer and, except as otherwise
provided in the Cut-Through Endorsements, shall not create any legal relationship whatsoever between the Reinsurer and any Person other than the Ceding Companies. 

Section 6.3 Reinsurance 

Without written consent of the Reinsurer (which consent may be withheld in Reinsurer’s sole discretion), the Ceding Companies shall not
terminate, modify or acquire Inuring Reinsurance. The Reinsurer may notify in writing the Ceding Companies as to Inuring Reinsurance that (a) it desires to be terminated, modified or acquired by the Ceding Companies and/or (b) under which
the Reinsurer desires to become a reinsured with respect to the Subject Business, and the Ceding Companies shall cooperate with the Reinsurer and use commercially reasonable efforts requested by the Reinsurer to so terminate, modify or acquire
Inuring Reinsurance and/or cause the Reinsurer to become a reinsured thereunder. 
 Section 6.4 Substitution of Managing General
Agency 
 The Ceding Companies agree that, at the request of the Reinsurer, the parties shall enter into a managing general agency
agreement (the “MGA Agreement”) by which the Ceding Companies or a designated affiliate shall act as the managing general agent for Reinsurer and its affiliates with respect to Subject Business. The MGA Agreement shall provide, to
the extent possible, for the payment of a commission to the managing general agent, which provides for equivalent economic benefit as the Ceding Commission provides. The Agreement shall further provide that the managing general agent shall retain
the renewal rights to the Subject Business. 
 Article 7 

INSOLVENCY 
 In the
event of the insolvency of a Ceding Company, this reinsurance as to Insurance Contracts issued by such Ceding Company shall be payable directly to such Ceding Company or its liquidator, receiver, conservator or statutory successor on the basis of
the amount of the claims allowed in the insolvency proceeding without diminution because of the insolvency of such Ceding Company or because the liquidator, receiver, conservator or statutory successor of such Ceding Company has failed or is unable
to pay all or a portion of a claim, except where (a) this Agreement specifically provides another payee of such reinsurance in the event of such Ceding Company’s insolvency, provided that this exception shall only apply to the extent that
the reinsurance proceeds due such payee are actually paid by the Reinsurer, or (b) the Reinsurer, 

  
 - 16 - 

 
with the consent of the direct insured or insureds, has assumed such policy obligations of such Ceding Company as direct obligations of the Reinsurer to the payees under such policies and in full
and complete substitution for the obligations of such Ceding Company to such payees. It is agreed, however, that the liquidator, receiver, conservator or statutory successor shall give written notice to the Reinsurer of the pendency of a claim
against such Ceding Company indicating the Subject Policy which involves a possible liability on the part of the Reinsurer within reasonable time after such claim is filed in the conservation or liquidation proceeding or in the receivership and
that, during the pendency of such claim, the Reinsurer may investigate such claim and interpose, at its own expense, in the proceeding where such claim is to be adjudicated, any defense or defenses that it may deem available to such Ceding Company
or its liquidator, receiver, conservator or statutory successor. The expenses thus incurred by the Reinsurer shall be chargeable, subject to the Court’s approval, against such Ceding Company as part of the expense of the conservation or
liquidation to the extent of a pro rata share of the benefit that may accrue to such Ceding Company solely as a result of the defense undertaken by the Reinsurer. 

Article 8 
 REGULATORY
APPROVALS 
 The Ceding Companies and the Reinsurer shall submit all necessary registrations, filings and notices with, and obtain all necessary
consents, approvals, qualifications and waivers from, all Governmental Authorities and other parties which may be required under Applicable Law as a result of the transactions contemplated by, or to perform its respective obligations under, this
Agreement. The Parties agree that where formal approval is required by any Governmental Authority, this Agreement shall not be effective as to any and all Insurance Contracts to be reinsured hereunder in such jurisdiction until such approval is
obtained. Notwithstanding the foregoing, this Agreement shall apply to all Insurance Contracts issued or to be issued in a particular jurisdiction to the extent that the Parties have agreed that no such approvals are required (including,
specifically, the approval of the issuance of the Cut-Through Endorsements) or such polices are issued by or at the direction or request of the Reinsurer. 

Article 9  

DURATION 
 This
Agreement shall terminate on the first anniversary of the date hereof and shall not otherwise be subject to termination except (i) by written agreement between Reinsurer and the Ceding Companies on the date indicated by such agreement, after
receipt of any required approval from Government Authorities, (ii) by written notice by the Reinsurer to the Ceding Companies following the termination of the Merger Agreement, (iii) upon the execution of the MGA Agreement, (iv) ten
(10) days following written notice by Reinsurer to the Ceding Companies, if any Ceding Company shall fail to remit to Reinsurer any Premium collected by such Ceding Company, unless such Premium is remitted within such ten (10) day period,
(v) thirty (30) days following written notice by Reinsurer or the Ceding Companies, on the one hand, to the Ceding Companies or Reinsurer, on the other hand, if the Party receiving such notice shall default in the performance of any of its
material obligations hereunder (other than the default described in subsection (iv)), unless such default, if curable, is cured within such thirty (30) day period and (vi) upon the expiration of all liability on all Insurance Contracts and
the 

  
 - 17 - 

 
complete performance by Reinsurer and the Ceding Companies of all obligations and duties arising under this Agreement; provided that, unless otherwise agreed by the Parties, following termination
of this Agreement pursuant to clauses (ii) through (vi) above, no further Subject Business will be ceded to Reinsurer, no Ceding Company will issue further Cut-Through Endorsements, Reinsurer shall remain liable hereunder with respect to
Insurance Contracts issued prior to such termination and Ceding Companies shall remain obligated to service, administer and manage the Insurance Contracts and Claims thereunder in accordance with the terms of this Agreement. 

Article 10 
 FOLLOW
THE FORTUNES 
 The Reinsurer’s liability shall attach simultaneously with that of each Ceding Company and shall be subject in
all respects to the same risks, original terms and conditions, interpretations, waivers, and to the same cancellation of the Insurance Contracts as such Ceding Company is subject to, the true intent of this Agreement being that the Reinsurer shall,
in every case to which this Agreement applies, follow the fortunes and follow the settlements of such Ceding Company. 
 Article 11

 INDEMNIFICATION 

Section 11.1 Indemnification. 

(a) Subject to the provisions of this Agreement, each Ceding Company agrees to indemnify and hold the Reinsurer and its
Affiliates, predecessors, successors and assigns (and their respective officers, directors, employees and agents) harmless from and against and in respect of all Damages resulting from or relating to a breach by such Ceding Company of any covenant
or agreement of such Ceding Company in this Agreement and to be performed post-Closing. 
 (b) Subject to the provisions of
this Agreement, the Reinsurer agrees to indemnify and hold each Ceding Company and its Affiliates, predecessors, successors and assigns (and their respective officers, directors, employees and agents) harmless from and against and in respect of all
Damages, resulting from or relating to a breach by the Reinsurer of any covenant or agreement of the Reinsurer in this Agreement. 

  
 - 18 - 

 Article 12 

MISCELLANEOUS 

Section 12.1 Notices. All notices, requests, demands and other communications hereunder shall be given in writing and shall
be: (a) personally delivered; (b) sent by telecopier, facsimile transmission or other electronic means of transmitting written documents; or (c) sent to the Parties at their respective addresses indicated herein by registered or
certified U.S. mail, return receipt requested and postage prepaid, or by private overnight mail courier service. The respective addresses to be used for all such notices, demands or requests are as follows: 

(a) If to a Ceding Company, to: 

Tower Group International, Ltd. 

120 Broadway (31st fl) 
 New
York, NY 10271 
 Attention: Bill Hitselberger 

Facsimile: (212) 202-3987 

E-mail: bhitselberger@twrgrp.com 
 or to such
other person or address as the Ceding Company shall furnish to the Reinsurer in writing. 
 (b) If to the Reinsurer, to: 

c/o National General Management Corp. 

59 Maiden Lane, 38th fl 
 New
York, NY 10038 
 Attn: Jeffrey Weissmann, Esq. 

Facsimile No.: (212) 380-9499 

E-mail: jeffrey.weissmann@ngic.com 
 or to such
other person or address as the Reinsurer shall furnish to the Ceding Companies in writing. 
 If personally delivered, such communication
shall be deemed delivered upon actual receipt; if electronically transmitted pursuant to this paragraph, such communication shall be deemed delivered the next business day after transmission (and sender shall bear the burden of proof of delivery);
if sent by overnight courier pursuant to this paragraph, such communication shall be deemed delivered upon receipt; and if sent by U.S. mail pursuant to this paragraph, such communication shall be deemed delivered as of the date of delivery
indicated on the receipt issued by the relevant postal service, or, if the addressee fails or refuses to accept delivery, as of the date of such failure or refusal. Any Party to this Agreement may change its address for the purposes of this
Agreement by giving notice thereof in accordance with this Section. 

  
 - 19 - 

 Section 12.2 Assignment; Parties in Interest. 

(a) Assignment. Except as expressly provided herein, the rights and obligations of a Party hereunder may not be
assigned, transferred or encumbered without the prior written consent of the other Party. 
 (b) Parties in Interest.
This Agreement shall be binding upon, inure to the benefit of, and be enforceable by the Parties and their respective successors and permitted assigns. Except as provided in Section 11.1, nothing contained herein shall be deemed to confer upon
any other Person any right or remedy under or by reason of this Agreement (other than pursuant to a Cut-Through Endorsement). 

  
 - 20 - 

 Section 12.3 Waivers and Amendments; Preservation of Remedies. This Agreement
may be amended, superseded, canceled, renewed or extended, and the terms hereof may be waived, only by a written instrument signed by each of the Parties or, in the case of a waiver, by the Party waiving compliance. No delay on the part of any Party
in exercising any right, power or privilege hereunder shall operate as a waiver thereof, nor shall any waiver on the part of any Party of any right, power, remedy or privilege, nor any single or partial exercise of any such right, power, remedy or
privilege, preclude any further exercise thereof or the exercise of any other such right, remedy, power or privilege. The rights and remedies herein provided are cumulative and are not exclusive of any rights or remedies that any Party may otherwise
have under Applicable Law or in equity. 
 Section 12.4 Governing Law; Venue. This Agreement shall be construed
and interpreted according to the internal laws of the State of New York excluding any choice of law rules that may direct the application of the laws of another jurisdiction. The Parties hereby stipulate that any action or other legal proceeding
arising under or in connection with this Agreement may be commenced and prosecuted in its entirety in the federal or state courts sitting in New York, New York, each Party hereby submitting to the personal jurisdiction thereof, and the Parties agree
not to raise the objection that such courts are not a convenient forum. Process and pleadings mailed to a party at the address provided in Section 12.1 shall be deemed properly served and accepted for all purposes. 

Section 12.5 Counterparts. This Agreement may be executed in one or more counterparts, each of which shall be deemed an
original, but all of which together shall constitute one and the same instrument.  
 Section 12.6 Entire Agreement;
Merger. This Agreement, and any exhibits, schedules and appendices attached hereto and thereto together constitute the final written integrated expression of all of the agreements among the Parties with respect to the subject matter hereof
and is a complete and exclusive statement of those terms, and supersede all prior or contemporaneous, written or oral, memoranda, arrangements, contracts and understandings between the Parties relating to the subject matter hereof. No addition to or
modification of any provision of this Agreement shall be binding upon either Party unless embodied in a dated written instrument signed by both Parties.  

Section 12.7 Exhibits and Schedules. All exhibits, schedules and appendices are hereby incorporated by reference into this
Agreement as if they were set forth at length in the text of this Agreement. 
 Section 12.8 Headings. The headings in
this Agreement are inserted for convenience only and shall not constitute a part hereof. 
 Section 12.9 Severability.
If any part of this Agreement is contrary to, prohibited by, or deemed invalid under Applicable Law or regulations, that provision shall not apply and shall be omitted to the extent so contrary, prohibited, or invalid; but the remainder of this
Agreement shall not be invalidated and shall be given full force and effect insofar as possible. 

  
 - 21 - 

 Section 12.10 Expenses. Regardless of whether or not the transactions
contemplated in this Agreement are consummated, each of the Parties shall bear their own expenses and the expenses of its counsel and other agents in connection with the transactions contemplated hereby. 

Section 12.11 Currency. The currency of this Agreement and all transactions under this Agreement shall be in United States
Dollars. 
 Section 12.12 Separate Agreements. This Agreement shall be considered to be a separate agreement between each
Ceding Company and the Reinsurer, and all accountings and settlements shall be on a Ceding Company-by-Ceding Company basis. 

(Signature Page Follows) 

  
 - 22 - 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed by their duly
authorized representatives as of the day and year first written above. 
  

			
	
	CEDING COMPANIES:
	
	TOWER INSURANCE COMPANY OF NEW YORK
		
	By	 	 /s/ Elliott Orol

		
	Title	 	 SVP

	
	CASTLE POINT NATIONAL INSURANCE COMPANY
		
	By	 	 /s/ Elliott Orol

		
	Title	 	 SVP

	
	TOWER NATIONAL INSURANCE COMPANY
		
	By	 	 /s/ Elliot Orol

		
	Title	 	 SVP

	
	HERMITAGE INSURANCE COMPANY
		
	By	 	 /s/ Elliot Orol

		
	Title	 	 SVP

	
	CASTLE POINT FLORIDA INSURANCE COMPANY
		
	By	 	 /s/ Elliot Orol

		
	Title	 	 SVP

  
 Personal Lines
Cut-Through Reinsurance Agreement Signature Page 

			
	KODIAK INSURANCE COMPANY
		
	By	 	 /s/ Elliott Orol

		
	Title	 	 SVP

	
	NORTH EAST INSURANCE COMPANY
		
	By	 	 /s/ Elliott Orol

		
	Title	 	 SVP

	
	YORK INSURANCE COMPANY OF MAINE
		
	By	 	 /s/ Elliott Orol

		
	Title	 	 SVP

	
	MASSACHUSETTS HOMELAND INSURANCE COMPANY
		
	By	 	 /s/ Elliott Orol

		
	Title	 	 SVP

	
	PRESERVER INSURANCE COMPANY
		
	By	 	 /s/ Elliott Orol

		
	Title	 	 SVP

	
	CASTLE POINT INSURANCE COMPANY
		
	By	 	 /s/ Elliott Orol

		
	Title	 	 SVP

  
 Personal Lines
Cut-Through Reinsurance Agreement Signature Page 

			
	REINSURER:
	
	INTEGON NATIONAL INSURANCE COMPANY
		
	By	 	 /s/ Mike Weiner

		
	Title	 	  

  
 Personal Lines
Cut-Through Reinsurance Agreement Signature Page 

 Exhibit A 

[Intentionally Omitted] 

[    ] 

  
 Exhibit A 

 Exhibit B 

Endorsement No.         

CUT-THROUGH ENDORSEMENT 
 This Endorsement
is made by and between [National General Affiliate] Insurance Company (the “Reinsurer”) and [Tower Affiliate] (the “Company”) for the benefit of the Insured named below with regard to Policy No.
         issued by the Company, to the Insured named below (the “Policy”) 
 Effective Date of This
Endorsement:                      
 Effective Date of
Policy:                      
 Name Insured:
                     
 The Reinsurer and the Company
agree as follows: 
 In the event that the Company is declared insolvent by a court of competent jurisdiction and is unable to pay a loss(es) under the
Policy occurring on or after the Effective Date of this Endorsement (a “Covered Loss”), (A) the Reinsurer will be liable to the Insured for such Covered Loss and will make payment directly to the Insured, subject to the terms, limits
and conditions contained in the Policy, (B) the Reinsurer shall be subrogated to all rights of the Insured and the Company to the extent of such payment, and (C) the Insured will have a direct right of action against the Reinsurer for
amounts payable under the Policy with respect to such Covered Loss. 
  

									
	New York, NY	 		 	New York, NY
			
	This      day of             , 2014	 		 	This      day of             , 2014
			
	[TOWER AFFILIATE]	 		 	INTEGON NATIONAL INSURANCE COMPANY
					
	By:	 	  
	 		 	By:	 	  

					
	Title:	 	  
	 		 	Title:	 	  

  
 Exhibit B 

 Exhibit C 

Reported Claims 
 Each Ceding Company will
provide prompt notice via electronic transmission (or as otherwise directed by Reinsurer) to the Reinsurer or its designee of all Claims where or in connection with: 

1. The total loss reserve is $250,000 or greater; 
 2.
amputations requiring a prosthesis; 
 3. brain damage affecting mentality or central nervous system (such as permanent disorientation, behavior disorder,
personality change, seizures, motor deficit, inability to speak, hemiplegia or unconsciousness); 
 4. blindness; 

5. burns (a) of the 3rd degree involving over 30% of body, (b) of the 2nd degree involving 50% of the body or (c) that are electrical and
involve any of the following: internal injury, amputations, spinal cord damage and brain injury; 
 6. multiple fractures involving one or more members or
non-union; 
 7. fracture of both heels (bilateral oscalis fractures); 

8. massive internal injury affecting body organs; 
 9. any
injury resulting in permanent total disability; 
 10. fatalities; 

11. any other serious injury; 
 12. each claim or loss where
there is continuous lost time in excess of four (4) years and which has not been previously reported to Reinsurer; 
 13. receipt of any suit or demand
that seeks extra-contractual damages; 
 14. the following injuries are identified: fatalities, brain injury damage affecting mentality or central nervous
system, spinal cord injury involving loss of mobility, significant burns or massive internal injury; 
 15. such Claims are reported 60 days or longer after
the date of Loss; 

  
 Exhibit C 

 16. any reported fire Loss (a) when the total insured value of the structure is more than $5,000,000,
(b) when a cause and origin investigator is appointed or (c) when the policy involves financial Losses; and 
 17. any suspected fraudulent Claim
or Loss due to fraud. 

  
 Exhibit C-2 

 Exhibit D 

Loss Fund Account Procedures 
 In addition to the
direction expressly set forth in the Agreement, the Ceding Companies (collectively, the “Claims Administrator”) agree to comply with the following procedures (the “Loss Fund Account Procedures”). In the event of any conflict
between the Loss Fund Account Procedures and the Agreement, the Agreement shall govern. 
 Where the following procedure directs Claims Administrator to
report to Reinsurer, such report should be directed to be designated in writing by the Reinsurer. 
  

	I.	CLAIM LOSS FUND ACCOUNT PROCEDURES 

  

	 	A.	Reinsurer will fund the Claim Loss Fund Account. The Claim Loss Fund Account will be funded in an amount that the Claims Administrator and Reinsurer agree is necessary for the purpose of paying Claims and Loss
Adjustment Expenses under the Subject Policy(ies). 

  

	 	B.	The Loss Fund Account will be established by the Claims Administrator in Reinsurer’s name; will be funded by Reinsurer; and will be administered, monitored and maintained by the Claims Administrator at such bank
approved from time to time by Reinsurer, said account being exclusively dedicated to purpose described in subsection I.A. immediately preceding. The account name will be “Tower Insurance Claims Fund FBO [Reinsurer Name]”. Reinsurer will be
authorized by Claims Administrator to designate up to four Authorized Check Signers on the account. Claims Administrator is responsible for all administration or banking fees charged to the escrow account. The deposits of funds in such bank shall be
insured by the Bank Insurance Fund or the Savings Associations Insurance Fund of the Federal Deposit Insurance Corporation. 

Claims Administrator shall maintain such account in a fiduciary capacity separate and apart from any operating or other funds of Claims
Administrator, and separate and apart from any other funds maintained by Claims Administrator on behalf of any other entity or person. The Claims Administrator shall not change the bank where the Loss Fund Account(s) is maintained without the prior
written approval of Reinsurer. The account will be established with Positive Pay unless otherwise approved in writing by Reinsurer. 
  

	 	C.	At the inception of the Policy(ies) and at the beginning of each month, the amount of the Loss Fund Account will equal an amount which represents a good faith estimate by Reinsurer of the number of days and expected
paid Claims and Loss Adjustment Expenses. The initial amount of the Loss Fund Account will be determined and deposited by Reinsurer. 

	 	D.	Claims Administrator and Reinsurer will review the amount of this Loss Fund Account periodically to determine the adequacy of the fund to cover a good faith estimate of the number of days of expected paid claims
(including paid Loss Adjustment Expenses), and Claims Administrator will provide Reinsurer with a quarterly cash flow forecast in a form and manner to be agreed upon. Notwithstanding the procedure above, Reinsurer will also monitor the adequacy of
the Claim Loss Fund Account and, when necessary, request to adjust the deposit to maintain the revised indicated needed amount. Reinsurer will advise Claims Administrator when the minimum amount is to be changed. 

 

	 	E.	Claims Administrator will administer and maintain the Claim Loss Fund Account and reconcile the account monthly. 

  

	 	F.	Claims Administrator will provide a report to Reinsurer by the tenth (10) business day of each month which indicates monthly, in arrears, a reconciliation of the claim Loss Fund Account, with the following
information: 

  

	 	1.	The previous closing account balance for the Claim Loss Fund Account; 

  

	 	2.	Deposits made to the Claim Loss Fund Account during the month; 

  

	 	3.	Itemization and application of the month’s disbursements by location, check number, claim number and payment amount; 

  

	 	4.	The Claim Loss Fund Account balance to the end of the month; and, 

  

	 	5.	A Reconciliation of the Loss Run Inception-To-Date to the Total Loss Funding and Ending Escrow Claim Loss Fund Account Balance in a format acceptable to Reinsurer. 

From time to time, Reinsurer may request Claims Administrator to provide additional summary or detail reports in printout or electronic format.

  

	 	G.	If the Agreement is terminated Claims Administrator shall monitor and administer the Claim Loss Fund Account until all liabilities under the Policy(ies) have been resolved or completely paid. 

 

	 	H.	Claims Administrator shall have no investment authority, or responsibility to Reinsurer with respect to funds deposited in the Claim Loss Fund Account. 

 

	 	I.	Claims Administrator shall handle all correspondence, transactions and instruments of payment in a manner that complies with all regulations concerning the use of bank accounts. All Claim payments will be made in Claims
Administrator’s name, on Reinsurer’s behalf. 

  
 - 2 - 

	II.	LOSS PAYMENT PROCEDURE 

  

	A.	Claimants must be paid for covered claims in accordance with regulatory requirements. For purposes of this paragraph A., the term “Claimants” means individuals or organizations that make a Claim under the
Policy(ies). 

  

	B.	Claims Administrator will establish procedures to make timely payments (within agreed to and statutory time frames) of qualified loss when due, and shall have the authority to commit funds from the Claim Loss Fund
Account. Drafts or checks should be issued in a timely manner and in accordance with the applicable rules, regulations and laws applicable of the jurisdiction(s) involved. 

 

	C.	Claims Administrator will retain copies of, or facsimile copies of, checks for seven (7) years from the date of bank clearance. 

  
 - 3 -EX-10.1

 Exhibit 10.1 

SECURITIES PURCHASE AGREEMENT 
 THIS
SECURITIES PURCHASE AGREEMENT (the “Agreement”), dated as of January 31, 2014, by and among Regado Biosciences, Inc., a Delaware corporation with headquarters located at 120 Mountain View Boulevard, Basking Ridge, New
Jersey 07920 (the “Company”), and the investors listed on the Schedule of Investors attached hereto as Exhibit A (individually, an “Investor” and collectively, the “Investors”). 

BACKGROUND 
 A. Each
Investor, severally and not jointly, wishes to purchase, and the Company wishes to sell, upon the terms and conditions stated in this Agreement, (i) that aggregate number of shares of the common stock, par value $0.001 per share, of the Company
(the “Common Stock”), set forth opposite such Investor’s name on Exhibit A hereto under the heading “Common Shares” (which aggregate amount for all Investors together shall be 4,000,000 shares of Common Stock
and shall collectively be referred to herein as the “Common Shares”). 
 B. The Company and each Investor are executing and
delivering this Agreement in reliance upon the exemption from registration afforded by Section 4(a)(2) of the Securities Act of 1933, as amended (the “Securities Act”), and Rule 506(b) of Regulation D (“Regulation
D”) as promulgated by the United States Securities and Exchange Commission (the “SEC”) under the Securities Act. 

C. The Common Shares to be issued pursuant to this Agreement are collectively referred to herein as the “Securities.” 

NOW, THEREFORE, IN CONSIDERATION of the mutual covenants contained in this Agreement, and for other good and valuable consideration the
receipt and adequacy of which are hereby acknowledged, the Company and the Investors agree as follows: 
 ARTICLE I 

DEFINITIONS 
 1.1
Definitions. In addition to the terms defined elsewhere in this Agreement, the following terms have the meanings indicated: 

“Additional Filing Date” means the later of (i) the date sixty (60) days after the date substantially all of the
Registrable Securities registered under the immediately preceding Registration Statement are sold and (ii) the date six (6) months from the Effective Date of the immediately preceding Registration Statement, or, if such date is not a
Business Day, the next date that is a Business Day. 
 “Additional Registration Statement” has the meaning set forth in
Section 6.1(a). 
 “Additional Required Effectiveness Date” means the date which is the earliest of (i) if
the Registration Statement does not become subject to review by the SEC, (a) sixty (60) days after the Additional Filing Date or (b) five (5) Trading Days after the Company receives notification from the SEC that the

 
Additional Registration Statement will not become subject to review and the Company fails to request to accelerate the effectiveness of the Registration Statement, or (ii) if the Additional
Registration Statement becomes subject to review by the SEC, ninety (90) days after the Additional Filing Date, or, if such date is not a Business Day, the next date that is a Business Day. 

“Affiliate” means any Person that, directly or indirectly through one or more intermediaries, controls or is controlled by or
is under common control with a Person, as such terms are used in and construed under Rule 144 under the Securities Act. 

“Agents” has the meaning set forth in Section 3.1(l). 

“Agreement” has the meaning set forth in the Preamble. 

“Business Day” means any day other than Saturday, Sunday or other day on which commercial banks in the City of New York are
authorized or required by law to remain closed. 
 “Closing” means the closing of the purchase and sale of the Securities
pursuant to Section 2.1. 
 “Closing Date” means the date and time of the Closing and shall be 11:00 a.m., New
York City time, on February 5, 2014 or such later date and time as is mutually agreed to by the Company and each Investor. 

“Closing Price” means, for any date, the closing price per share of the Common Stock for such date (or, if such date is not a
Trading Day, the nearest preceding date that is a Trading Day) on the primary Eligible Market or exchange or quotation system on which the Common Stock is then listed or quoted. 

“Company” has the meaning set forth in the Preamble. 

“Company Counsel” means Lowenstein Sandler LLP, counsel to the Company. 

“Common Shares” has the meaning set forth in the Preamble. 

“Common Stock Equivalents” means, collectively, Options and Convertible Securities. 

“Company’s Knowledge” means with respect to any statement made to the knowledge of the Company, that statement is based
upon the actual knowledge of the chief executive officer, the president and chief operating office, the chief medical officer and the chief scientific officer of the Company, in each case after making reasonable inquiry. 

“Contingent Obligation” has the meaning set forth in Section 3.1(dd). 

“Convertible Securities” means any stock or securities (other than Options) convertible into or exercisable or exchangeable
for Common Stock. 
 “Disclosure Materials” has the meaning set forth in Section 3.1(g). 

“Effective Date” means the date that a Registration Statement is first declared effective by the SEC. 

“Effectiveness Period” has the meaning set forth in Section 6.1(b). 

“8-K Filing” has the meaning set forth in Section 4.4. 

  
 -2- 

 “Eligible Market” means any of The New York Stock Exchange, Inc., The NYSE MKT,
The NASDAQ Global Select Market, The NASDAQ Global Market or The NASDAQ Capital Market. 
 “Environmental Laws” has the
meaning set forth in Section 3.1(ff). 
 “Event” has the meaning set forth in Section 6.1(d). 

“Event Payments” has the meaning set forth in Section 6.1(d). 

“Exchange Act” means the Securities Exchange Act of 1934, as amended. 

“Excluded Events” has the meaning set forth in Section 6.1(d)(ii). 

“Excluded Investors” means Cowen and Company, LLC and its Affiliates, other than Ramius LLC and any investment funds or
managed accounts managed or advised by Ramius LLC. 
 “Filing Date” means the Initial Filing Date and the Additional Filing
Date, as applicable. 
 “GAAP” has the meaning set forth in Section 3.1(g). 

“Hazardous Materials” has the meaning set forth in Section 3.1(ff). 

“Indebtedness” has the meaning set forth in Section 3.1(cc). 

“Indemnified Party” has the meaning set forth in Section 6.4(c). 

“Indemnifying Party” has the meaning set forth in Section 6.4(c). 

“Insider” means each director, executive officer, other officer of the Company participating in the offering, any beneficial
owner of 20% or more of the Company’s outstanding voting equity securities, calculated on the basis of voting power and any promoter connected with the Company issuer in any capacity on the date hereof. 

“Insider Certification” means the certification in the form of Exhibit G, to be executed and delivered by each Insider
prior to the execution and delivery of this Agreement. 
 “Initial Filing Date” means the earlier of (i) sixty
(60) days after the Closing Date or, if such date is not a Business Day, the next date that is a Business Day, and (ii) the fifth (5th) Business Day after the date on which the
Company files its Annual Report on Form 10-K for the year ended December 31, 2013 with the SEC. 
 “Initial Registration
Statement” has the meaning set forth in Section 6.1(a). 
 “Initial Required Effectiveness Date” means
the date which is the earliest of (i) if the Registration Statement does not become subject to review by the SEC, (a) one hundred and twenty (120) days after the Closing Date or (b) five (5) Trading Days after the Company
receives notification from the SEC that the Registration Statement will not become subject to review and the Company fails to request to accelerate the effectiveness of the Registration Statement, or (ii) if the Registration Statement becomes
subject to review by the SEC, one hundred and fifty (150) days after the Closing Date, or, if such date is not a Business Day, the next date that is a Business Day. 

  
 -3- 

 “Insolvent” has the meaning set forth in Section 3.1(h). 

“Intellectual Property Rights” has the meaning set forth in Section 3.1(u). 

“Lien” means any lien, charge, claim, security interest, encumbrance, right of first refusal or other restriction, other than
those arising under applicable securities laws. 
 “Losses” means any and all losses, claims, damages, liabilities,
settlement costs and expenses, including, without limitation reasonable attorneys’ fees. 
 “Material Adverse Effect”
means (i) a material adverse effect on the financial condition, results of operations, assets, business or prospects of the Company and the Subsidiaries, taken as a whole, or (ii) a material and adverse impairment of the Company’s
ability to perform its obligations under any of the Transaction Documents. 
 “Material Contract” means any contract of the
Company that has been filed or was required to have been filed as an exhibit to the SEC Reports pursuant to Item 601(b)(4) or Item 601(b)(10) of Regulation S-K. 

“Material Permits” has the meaning set forth in Section 3.1(u). 

“Options” means any outstanding rights, warrants or options to subscribe for or purchase Common Stock or Convertible
Securities. 
 “Person” has the meaning set forth in Section 3.1(dd). 

“Proceeding” means an action, claim, suit, investigation or proceeding (including, without limitation, a partial proceeding,
such as a deposition), whether commenced or threatened in writing. 
 “Prospectus” means the prospectus included in the
Registration Statement (including, without limitation, a prospectus that includes any information previously omitted from a prospectus filed as part of an effective registration statement in reliance upon Rule 430A promulgated under the Securities
Act), as amended or supplemented by any prospectus supplement, with respect to the terms of the offering of any portion of the Registrable Securities covered by the Registration Statement, and all other amendments and supplements to the Prospectus
including post-effective amendments, and all material incorporated by reference or deemed to be incorporated by reference in such Prospectus. 

“Registrable Securities” means the Common Shares issued or issuable pursuant to the Transaction Documents, together with any
securities issued or issuable upon any stock split, dividend or other distribution, recapitalization or similar event with respect to the foregoing, provided, that the Investor has completed and delivered to the Company a Registration
Statement Questionnaire; and provided, further, that the Common Shares shall cease to be Registrable Securities upon the earliest to occur of the following: (A) sale pursuant to a Registration Statement or Rule 144 under the
Securities Act, or (B) becoming eligible for sale by an Investor pursuant to Rule 144 without the requirement to be in compliance with Rule 144(c)(1). 

“Registration Statement” means each registration statement required to be filed under Article VI, including the Initial
Registration Statement, all Additional Registration Statements, and, in each case, the Prospectus, amendments and supplements to such registration statement or Prospectus, including pre- and post-effective amendments, all exhibits thereto, and all
material incorporated by reference or deemed to be incorporated by reference in such registration statement. 

  
 -4- 

 “Required Effectiveness Date” means the Initial Required Effectiveness Date and
the Additional Required Effectiveness Date, as applicable. 
 “Required Investors” means (i) prior to the Closing
Date, the Investors agreeing to acquire a majority of the Common Shares to be sold hereunder and (ii) as of any date from and after the Closing Date, the Investors holding a majority of the Common Shares then held by all of the Investors on
such date. 
 “Rule 144,” “Rule 415,” and “Rule 424” means Rule 144, Rule 415 and Rule
424, respectively, promulgated by the SEC pursuant to the Securities Act, as such Rules may be amended from time to time, or any similar rule or regulation hereafter adopted by the SEC having substantially the same effect as such Rule. 

“SEC” has the meaning set forth in the Preamble. 

“Securities” has the meaning set forth in the Preamble. 

“Securities Act” has the meaning set forth in the Preamble. 

“SEC Guidance” means (i) Rule 415 promulgated under the Securities Act and (ii) any publicly-available written or
oral guidance, comments, requirements or requests of the SEC staff regarding Rule 415. 
 “SEC Reports” has the meaning set
forth in Section 3.1(g). 
 “Shares” means shares of the Company’s Common Stock. 

“Short Sales” has the meaning set forth in Section 3.2(h). 

“Subsidiary” means any Significant Subsidiary (which for purposes of this Agreement has the meaning ascribed to such term in
Regulation S-X under the Exchange Act) of the Company. 
 “Trading Day” means (a) any day on which the Common Stock is
listed or quoted and traded on its primary Trading Market, or (b) if the Common Stock is not then listed or quoted and traded on its primary Trading Market, then a day on which trading of the Common Stock occurs on an Eligible Market, or
(c) if the Common Stock is not listed or quoted as set forth in clauses (a) or (b) hereof, any Business Day. 

“Trading Market” means The NASDAQ Capital Market or any other Eligible Market, or any national securities exchange, market or
trading or quotation facility on which the Common Stock is then listed or quoted. 
 “Transaction Documents” means this
Agreement, the schedules and exhibits attached hereto and the Transfer Agent Instructions. 
 “Transfer Agent” means
American Stock Transfer & Trust Company, or any successor transfer agent for the Company. 
 “Transfer Agent
Instructions” means, with respect to the Company, the Irrevocable Transfer Agent Instructions, in the form of Exhibit E, executed by the Company and delivered to and acknowledged in writing by the Transfer Agent. 

  
 -5- 

 ARTICLE II 

PURCHASE AND SALE 
 2.1
Closing. Subject to the terms and conditions set forth in this Agreement, at the Closing the Company shall issue and sell to each Investor, and each Investor shall, severally and not jointly, purchase from the Company, the number of Common
Shares set forth opposite such Investor’s name on Exhibit A hereto under the heading “Common Shares” for the price set forth opposite such Investor’s name on Exhibit A hereto under the heading “Purchase
Price”. The date and time of the Closing and shall be 11:00 a.m., New York City time, on the Closing Date. The Closing shall take place at the offices of the Company Counsel. 

2.2 Closing Deliveries. 

(a) At the Closing, the Company shall deliver or cause to be delivered to each Investor the following: 

(i) A direct registration book-entry advice statement (“book-entry statement”) from the Transfer Agent evidencing that such
number of Common Shares set forth opposite such Investor’s name on Exhibit A hereto under the heading “Common Shares”, have been credited to the account of such Investor (or its designee) in book-entry form; 

(ii) a legal opinion of Company Counsel, in the form of Exhibit C, executed by such counsel and delivered to the Investors and the
Agents; 
 (iii) duly executed Transfer Agent Instructions acknowledged by the Company’s transfer agent; and 

(iv) evidence of the filing of a Listing of Additional Shares Notification with the Trading Market covering all of the Common Shares. 

(b) At the Closing, each Investor shall deliver or cause to be delivered to the Company the purchase price set forth opposite
such Investor’s name on Exhibit A hereto under the heading “Purchase Price” in United States dollars and in immediately available funds, by wire transfer to an account designated in writing to such Investor by the Company for
such purpose. 
 ARTICLE III 

REPRESENTATIONS AND WARRANTIES 

3.1 Representations and Warranties of the Company. The Company hereby represents and warrants to the Investors as of the date hereof
(except for the representations and warranties that speak as of a specific date, which shall be made as of such date), that: 

(a) Subsidiaries. Except as disclosed in the SEC Reports, the Company has no Subsidiaries. The Company owns, directly
or indirectly, all of the capital stock or comparable equity interests of each Subsidiary free and clear of any Lien, all the issued and outstanding shares of capital stock or comparable equity interest of each Subsidiary are validly issued and are
fully paid, non-assessable and free of preemptive and similar rights, and the Company or one of its Subsidiaries has the unrestricted right to vote and (subject to limitations imposed by applicable law) to receive dividends and distributions on all
capital securities of its Subsidiaries as owned by the Company or such Subsidiary. 

  
 -6- 

 (b) Organization and Qualification. Each of the Company and the
Subsidiaries is an entity duly organized, validly existing and in good standing under the laws of the jurisdiction of its incorporation or organization (as applicable), with the requisite legal authority to own and use its properties and assets and
to carry on its business as currently conducted. Neither the Company nor any Subsidiary is in violation of any of the provisions of its respective certificate or articles of incorporation, bylaws or other organizational or charter documents. Each of
the Company and the Subsidiaries is duly qualified to do business and is in good standing as a foreign corporation or other entity in each jurisdiction in which the nature of the business conducted or property owned by it makes such qualification
necessary, except where the failure to be so qualified or in good standing, as the case may be, would not, individually or in the aggregate, have or reasonably be expected to result in a Material Adverse Effect. 

(c) Authorization; Enforcement. The Company has the requisite corporate authority to enter into and to consummate the
transactions contemplated by each of the Transaction Documents to which it is a party and otherwise to carry out its obligations hereunder and thereunder. The execution and delivery of each of the Transaction Documents to which it is a party by the
Company and the consummation by it of the transactions contemplated hereby and thereby have been duly authorized by all necessary corporate action on the part of the Company and no further consent or action is required by the Company, its Board of
Directors or its stockholders. Each of the Transaction Documents to which it is a party has been (or upon delivery will be) duly executed by the Company and is, or when delivered in accordance with the terms hereof, will constitute, the valid and
binding obligation of the Company enforceable against the Company in accordance with its terms, except as may be limited by (i) applicable bankruptcy, insolvency, reorganization or other laws of general application relating to or affecting the
enforcement of creditors rights generally, and (ii) the effect of rules of law governing the availability of specific performance and other equitable remedies. 

(d) No Conflicts. The execution, delivery and performance of the Transaction Documents to which it is a party by the
Company and the consummation by the Company of the transactions contemplated hereby and thereby do not, and will not, (i) conflict with or violate any provision of the Company’s or any Subsidiary’s certificate or articles of
incorporation, bylaws or other organizational or charter documents, (ii) conflict with, or constitute a default (or an event that with notice or lapse of time or both would become a default) under, or give to others any rights of termination,
amendment, acceleration or cancellation (with or without notice, lapse of time or both) of, any Material Contract to which the Company or any Subsidiary is a party or by which any property or asset of the Company or any Subsidiary is bound, or
affected, except to the extent that such conflict, default, termination, amendment, acceleration or cancellation right would not reasonably be expected to have a Material Adverse Effect, or (iii) result in a violation of any law, rule,
regulation, order, judgment, injunction, decree or other restriction of any court or governmental authority to which the Company or any Subsidiary is subject (including, assuming (A) the accuracy of the representations and warranties of the
Investors set forth in Section 3.2 hereof, (B) none of the Insiders and the Agents is subject to any “bad actor” disqualification specified in Rule 506(d) of Regulation D, and (C) the Insiders and the Agents have
complied with the “bad actor” disclosure requirements set forth in Rule 506(e) of Regulation D, federal and state securities laws and regulations and the rules and regulations of any self-regulatory organization to which the Company or its
securities are subject, including all applicable Trading Markets), or by which any property or asset of the Company or any Subsidiary is bound or affected, except to the extent that such violation would not reasonably be expected to have a Material
Adverse Effect. 
 (e) The Securities. The Securities are duly authorized and, when issued and paid for in accordance
with the Transaction Documents, will be duly and validly issued, fully paid and 

  
 -7- 

 
nonassessable, free and clear of all Liens and will not be subject to preemptive or similar rights of stockholders (other than those imposed by the Investors). Assuming (A) the accuracy of
the representations and warranties of the Investors set forth in Section 3.2 hereof, (B) none of the Insiders and the Agents is subject to any “bad actor” disqualification specified in Rule 506(d) of Regulation D, and
(C) the Insiders and the Agents have complied with the “bad actor” disclosure requirements set forth in Rule 506(e) of Regulation D, the offer, issuance and sale of the Common Shares to the Investors pursuant to the Agreement, are
exempt from the registration requirements of the Securities Act. 
 (f) Capitalization. The SEC Reports accurately
set forth the Company’s capitalization as of September 30, 2013, including Options and Convertible Securities of the Company outstanding as of such date. All outstanding shares of capital stock are duly authorized, validly issued, fully
paid and nonassessable and have been issued in compliance in all material respects with all applicable securities laws. Except as disclosed in the SEC Reports, the Company did not have outstanding at September 30, 2013 any other options,
warrants, script rights to subscribe to, calls or commitments of any character whatsoever relating to, or securities, rights or obligations convertible into or exercisable or exchangeable for, or entered into any agreement giving any Person any
right to subscribe for or acquire, any shares of Common Stock, or securities or rights convertible or exchangeable into shares of Common Stock. Except as disclosed in the SEC Reports, since September 30, 2013 the Company has not issued any
shares of capital stock, Options or Convertible Securities other than pursuant to the granting of awards under the Company’s outstanding incentive plans described in the SEC Reports and the issuance of shares of Common Stock upon the exercise
thereof. Except as disclosed in the SEC Reports, and except for customary adjustments as a result of stock dividends, stock splits, combinations of shares, reorganizations, recapitalizations, reclassifications or other similar events, there are no
anti-dilution or price adjustment provisions contained in any security issued by the Company (or in any agreement providing rights to security holders) and the issuance and sale of the Securities will not obligate the Company to issue shares of
Common Stock or other securities to any Person (other than the Investors) and will not result in a right of any holder of securities to adjust the exercise, conversion, exchange or reset price under such securities. To the Company’s Knowledge,
except as disclosed in the SEC Reports and any Schedules filed with the SEC pursuant to Rule 13d-1 of the Exchange Act by reporting persons, no Person or group of related Persons beneficially owns (as determined pursuant to Rule 13d-3 under the
Exchange Act), or has the right to acquire, by agreement with or by obligation binding upon the Company, beneficial ownership of in excess of 5% of the outstanding Common Stock. 

(g) SEC Reports. The Company has filed all registration statements and all reports required to be filed by it under the
Securities Act and the Exchange Act, including pursuant to Section 13(a) or 15(d) thereof, for the twelve (12) months preceding the date hereof, or such shorter period of time that the Company was subject to such filing requirements, on a
timely basis or has received a valid extension of such time of filing and has filed any such SEC Reports prior to the expiration of any such extension and has filed all reports required to be filed by it under the Exchange Act, including pursuant to
Section 13(a) or 15(d) thereof, for the twelve (12) months preceding the date hereof or such shorter period of time that the Company was subject to such filing requirements. The Company’s registration statement on Form S-1 (file no.:
333-188209), as declared effective by the SEC on August 21, 2013, as supplemented by the final prospectus filed with the SEC on August 22, 2013, and such reports required to be filed by the Company under the Exchange Act, including
pursuant to Section 13(a) or 15(d) thereof, together with any materials filed or furnished by the Company under the Exchange Act, whether or not any such reports were required being collectively referred to herein as the “SEC
Reports” and, together with this Agreement and the Schedules to this Agreement, the “Disclosure Materials”. As of their respective dates, the SEC Reports filed by the Company complied in all material respects with the
requirements of the Securities Act and the Exchange Act and the rules and 

  
 -8- 

 
regulations of the SEC promulgated thereunder, and none of the SEC Reports, when filed by the Company or declared effective by the SEC, in the case of any registration statement filed pursuant to
the Securities Act, contained any untrue statement of a material fact or omitted to state a material fact required to be stated therein or necessary in order to make the statements therein, in the light of the circumstances under which they were
made, not misleading. The financial statements of the Company included in the SEC Reports comply in all material respects with applicable accounting requirements and the rules and regulations of the SEC with respect thereto as in effect at the time
of filing. Such financial statements have been prepared in accordance with United States generally accepted accounting principles applied on a consistent basis during the periods involved (“GAAP”), except as may be otherwise
specified in such financial statements, the notes thereto and except that unaudited financial statements may not contain all footnotes required by GAAP or may be condensed or summary statements, and fairly present in all material respects the
consolidated financial position of the Company and its consolidated Subsidiaries as of and for the dates thereof and the results of operations and cash flows for the periods then ended, subject, in the case of unaudited statements, to normal,
year-end audit adjustments. All material agreements to which the Company or any Subsidiary is a party or to which the property or assets of the Company or any Subsidiary are subject are included as part of or identified in the SEC Reports, to the
extent such agreements are required to be included or identified pursuant to the rules and regulations of the SEC. 
 (h)
Financial Statements Since the date of the latest audited financial statements included within the SEC Reports, except as disclosed in the SEC Reports: (i) there has been no event, occurrence or development that, individually or in the
aggregate, has had or that would result in a Material Adverse Effect, (ii) the Company has not incurred any material liabilities other than (A) trade payables and accrued expenses incurred in the ordinary course of business consistent with
past practice and (B) liabilities not required to be reflected in the Company’s financial statements pursuant to GAAP or required to be disclosed in filings made with the SEC, (iii) the Company has not altered its method of accounting
or the changed its auditors, except as disclosed in its SEC Reports, (iv) the Company has not declared or made any dividend or distribution of cash or other property to its stockholders, in their capacities as such, or purchased, redeemed or
made any agreements to purchase or redeem any shares of its capital stock (except for repurchases by the Company of shares of capital stock held by employees, officers, directors, or consultants pursuant to an option of the Company to repurchase
such shares upon the termination of employment or services), and (v) the Company has not issued any equity securities to any officer, director or Affiliate, except pursuant to existing Company incentive plans. The Company has not taken any
steps to seek protection pursuant to any bankruptcy law and the Company has not received any written notice that any Person intends to initiate involuntary bankruptcy proceedings against the Company or any Subsidiary. The Company is not as of the
date hereof, and after giving effect to the transactions contemplated hereby to occur at the applicable Closing, will not be Insolvent (as defined below). For purposes of this Section 3.1(h), “Insolvent” means (i) the
present fair saleable value of the Company’s assets is less than the amount required to pay the Company’s total Indebtedness (as defined in Section 3.1(aa)), (ii) the Company is unable to pay its debts and liabilities,
subordinated, contingent or otherwise, as such debts and liabilities become absolute and matured, (iii) the Company intends to incur or believes that it will incur debts that would be beyond its ability to pay as such debts mature, or
(iv) the Company has unreasonably small capital with which to conduct the business in which it is engaged. 
 (i)
Absence of Litigation. Except as disclosed in the SEC Reports, there is no action, suit, claim, or Proceeding, or, to the Company’s Knowledge, inquiry or investigation, before or by any court, public board, government agency,
self-regulatory organization or body pending or, to the Company’s Knowledge, threatened in writing against or affecting the Company or any of its Subsidiaries that, individually or in the aggregate, would be reasonably be expected to result in
a Material Adverse Effect. 

  
 -9- 

 (j) Compliance. Neither the Company nor any Subsidiary, except in each
case as would not, individually or in the aggregate, reasonably be expected to have or result in a Material Adverse Effect, (i) is in default under or in violation of (and no event has occurred that has not been waived that, with notice or
lapse of time or both, would result in a default by the Company or any Subsidiary under), nor has the Company or any Subsidiary received written notice of a claim that it is in default under or that it is in violation of, any Material Contract to
which it is a party or by which it or any of its properties is bound (whether or not such default or violation has been waived), (ii) is in violation of any order of any court, arbitrator or governmental body, or (iii) is or has been in
violation of any statute, rule or regulation of any governmental authority. 
 (k) Title to Assets. The Company and
the Subsidiaries have good and marketable title, or have valid rights to lease or otherwise use, to all real property owned by them that is material to the business of the Company and the Subsidiaries and good and marketable title in all personal
property owned by them that is material to the business of the Company and the Subsidiaries, in each case free and clear of all Liens, except for Liens that do not, individually or in the aggregate, have or result in a Material Adverse Effect. Any
real property and facilities held under lease by the Company and the Subsidiaries are held by them under valid, subsisting and enforceable leases of which the Company and the Subsidiaries are in compliance, except for any non-compliance or breach
that does not, individually or in the aggregate, have or result in a Material Adverse Effect. 
 (l) No General
Solicitation; Placement Agents’ Fees. Neither the Company, nor any of its Affiliates, nor any Person acting on its or their behalf, has engaged in any form of general solicitation or general advertising (within the meaning of
Regulation D) in connection with the offer or sale of the Securities. The Company shall be responsible for the payment of any placement agents’ fees, financial advisory fees, or brokers’ commission (other than for persons engaged by
any Investor or its investment advisor) relating to or arising out of the issuance of the Securities pursuant to this Agreement. The Company shall pay, and hold each Investor harmless against, any liability, loss or expense (including, without
limitation, reasonable attorney’s fees and out-of-pocket expenses) arising in connection with any such claim for fees arising out of the issuance of the Securities pursuant to this Agreement. The Company acknowledges that it has engaged Cowen
and Company, LLC and BMO Capital Markets Corp. as its placement agents (the “Agents”) in connection with the sale of the Securities. Other than the Agents, the Company has not engaged any placement agent or other agent in connection
with the sale of the Securities. 
 (m) Rule 506 Compliance. Assuming (A) the accuracy of the representations
and warranties of the Investors set forth in Section 3.2 hereof, (B) none of the Insiders and the Agents is subject to any “bad actor” disqualification specified in Rule 506(d) of Regulation D, and (C) the Insiders
and the Agents have complied with the “bad actor” disclosure requirements set forth in Rule 506(e) of Regulation D, the Company is not disqualified from relying on Rule 506 of Regulation D under the Securities Act (“Rule
506”) for any of the reasons stated in Rule 506(d) in connection with the issuance and sale of the Common Shares to the Investor pursuant to this Agreement. The Company has exercised reasonable care, including without limitation, conducting
a factual inquiry that is appropriate in light of the circumstances, into whether any such disqualification under Rule 506(d) exists. The Company has furnished to each Investor, a reasonable time prior to the date hereof, a description in writing of
any matters relating to the Company or the Insiders that would have triggered disqualification under Rule 506(d) but which occurred before September 23, 2013, in each case, in compliance with the disclosure requirements of Rule 506(e). The
Company has exercised reasonable 

  
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care, including without limitation, conducting a factual inquiry that is appropriate in light of the circumstances, into whether any such disqualification under Rule 506(d) would have existed and
whether any disclosure is required to be made to Investor under Rule 506(e). Any outstanding securities of the Company (of any kind or nature) that were issued in reliance on Rule 506 at any time on or after September 23, 2013 have been issued
in compliance with Rule 506(d) and (e). 
 (n) Private Placement. Neither the Company nor any Person acting on the
Company’s behalf has, directly or indirectly, at any time within the past six months, made any offer or sale of any security or solicitation of any offer to buy any security under circumstances that would (i) eliminate the availability of
the exemption from registration under Regulation D under the Securities Act in connection with the offer and sale by the Company of the Securities as contemplated hereby or (ii) cause the offering of the Securities pursuant to the
Transaction Documents to be integrated with prior offerings by the Company for purposes of any applicable law, regulation or stockholder approval provisions, including, without limitation, under the rules and regulations of any Trading Market. The
sale and issuance of the Securities hereunder does not contravene the rules and regulation of any applicable Trading Market on which the Common Stock is listed or quoted. 

(o) Investment Act. The Company is not required to be registered as, and is not an Affiliate of, an “investment
company” within the meaning of the Investment Company Act of 1940, as amended. 
 (p) [Intentionally Omitted.]

 (q) Listing and Maintenance Requirements. The Company has not, since August 22, 2013, received notice
(written or oral) from any Trading Market on which the Common Stock is or has been listed or quoted to the effect that the Company is not in compliance with the listing or maintenance requirements of such Trading Market. The Company is in compliance
with all such listing and maintenance requirements. 
 (r) Registration Rights. Except as described in the SEC
Reports, the Company has not granted or agreed to grant to any Person any rights (including “piggy-back” registration rights) to have any securities of the Company registered with the SEC or any other governmental authority. All such
registration rights have either been satisfied or waived so that: (i) no Person shall have the right to demand the filing of a registration statement for the registration of any Company securities (other than the Securities to be issued
hereunder) prior to the Effective Date of the Initial Registration Statement, and (ii) no Person shall have the right to demand the inclusion of any Company securities (other than the Securities to be issued hereunder) in the Registration
Statement. 
 (s) Application of Takeover Protections. There is no control share acquisition, business combination,
poison pill (including any distribution under a rights agreement) or other similar anti-takeover provision under the Company’s charter documents or the laws of its state of incorporation that is or could become applicable to any of the
Investors as a result of the Investors and the Company fulfilling their obligations or exercising their rights under the Transaction Documents, including, without limitation, as a result of the Company’s issuance of the Securities and the
Investors’ ownership of the Securities. 
 (t) Disclosure. The Company confirms that neither it nor any officers
or directors, has provided any of the Investors (other than Excluded Investors) or their agents or counsel with any information that constitutes or might constitute material, nonpublic information (other than the existence and terms of the issuance
of Securities, as contemplated by this Agreement). The Company understands and confirms that each of the Investors will rely on the foregoing representations in effecting transactions in securities of the Company (other than Excluded Investors).

  
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 (u) Acknowledgment Regarding Investors’ Purchase of Securities.
Based upon the assumption that the transactions contemplated by this Agreement are consummated in all material respects in conformity with the Transaction Documents, the Company acknowledges and agrees that each of the Investors (other than Excluded
Investors) is acting solely in the capacity of an arm’s length purchaser with respect to the Transaction Documents and the transactions contemplated hereby and thereby. The Company further acknowledges that no Investor (other than Excluded
Investors) is acting as a financial advisor or fiduciary of the Company (or in any similar capacity) with respect to this Agreement and the transactions contemplated hereby and any advice given by any Investor (other than Excluded Investors) or any
of their respective representatives or agents in connection with the Transaction Documents and the transactions contemplated hereby and thereby is merely incidental to the Investors’ purchase of the Securities. The Company further represents to
each Investor that the Company’s decision to enter into this Agreement has been based solely on the independent evaluation of the transactions contemplated hereby by the Company and its representatives. 

(v) Patents and Trademarks. The Company and its Subsidiaries own or possess the valid right to use, or can acquire on
reasonable terms ownership of or rights to use, all (i) patents, patent applications, trademarks, trademark registrations, service marks, service mark registrations, Internet domain name registrations, copyrights, copyright registrations,
licenses, trade secret rights (“Intellectual Property Rights”) and (ii) inventions, software, works of authorships, trademarks, service marks, trade names, databases, formulae, know how, Internet domain names and other
intellectual property (including trade secrets and other unpatented and/or unpatentable proprietary confidential information, systems, or procedures) (collectively, “Intellectual Property Assets”) necessary to conduct their
respective businesses as currently conducted, and as proposed to be conducted and described in the SEC Reports. To the Company’s Knowledge, all Intellectual Property Rights are valid and enforceable. The Company and its Subsidiaries have not
received any opinion from their legal counsel concluding that any activities of their respective businesses infringe, misappropriate, or otherwise violate, valid and enforceable Intellectual Property Rights of any other person, and have not received
written notice of any challenge, which is to the Company’s Knowledge still pending, by any other person to the rights of the Company and its Subsidiaries with respect to any Intellectual Property Rights or Intellectual Property Assets owned or
used by the Company or its Subsidiaries. To the Company’s Knowledge, the Company and its Subsidiaries’ respective businesses as now conducted do not give rise to any infringement of, any misappropriation of, or other violation of, any
valid and enforceable Intellectual Property Rights of any other person. All licenses for the use of the Intellectual Property Rights, which are filed as Material Contracts, are valid, binding upon, and enforceable against the Company and, to the
Company’s Knowledge, the other parties thereto in accordance to its terms. The Company has complied in all material respects with, and is not breach nor has received any written notice asserting or threatening any claim of breach of any
intellectual property license, and to the Company’s Knowledge there is no breach or anticipated breach by any other person to any intellectual property license. Except as disclosed in the SEC Reports, there is no pending claim against the
Company alleging the infringement by the Company of any patent, trademark, service mark, trade name, copyright, trade secret, license in or other intellectual property right or franchise right of any person. The Company has taken reasonable steps to
protect, maintain and safeguard its Intellectual Property Rights, including the execution of appropriate nondisclosure and confidentiality agreements. 

(w) Insurance. The Company and the Subsidiaries are covered by insurance in such amounts and covering such risks as the
Company has reasonably determined is adequate for the conduct of its business and its properties. 

  
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 (x) Regulatory Permits. The Company and the Subsidiaries possess all
certificates, authorizations and permits issued by the appropriate federal, state, local or foreign regulatory authorities necessary to conduct their respective businesses as presently conducted and described in the SEC Reports (“Material
Permits”), except where the failure to possess such permits does not, individually or in the aggregate, have or reasonably be expected to result in a Material Adverse Effect, and neither the Company nor any Subsidiary has received any
written notice of proceedings relating to the revocation or modification of any Material Permit. 
 (y) Transactions With
Affiliates and Employees. Except as set forth or incorporated by reference in the Company’s SEC Reports, none of the officers, directors or employees of the Company is presently a party to any transaction that would be required to be
reported on Form 10-K with the Company or any of its Subsidiaries (other than for ordinary course services as employees, officers or directors), including any contract, agreement or other arrangement providing for the furnishing of services to or
by, providing for rental of real or personal property to or from, or otherwise requiring payments to or from any such officer, director or employee or, to the Company’s Knowledge, any corporation, partnership, trust or other entity in which any
such officer, director, or employee has a substantial interest or is an officer, director, trustee or partner. 
 (z)
Internal Accounting Controls. The Company and the Subsidiaries maintain a system of internal accounting controls sufficient to provide reasonable assurance that (i) transactions are executed in accordance with management’s general
or specific authorizations, (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with generally accepted accounting principles and to maintain asset accountability, (iii) access to assets
is permitted only in accordance with management’s general or specific authorization, and (iv) the recorded accountability for assets is compared with the existing assets at reasonable intervals and appropriate action is taken with respect
to any differences. Except as set forth in the SEC Reports, there has been no material weakness in the Company’s internal control over financial reporting (whether or not remediated). 

(aa) Disclosure Controls and Procedures. The Company maintains disclosure controls and procedures (as such term is
defined in Rule 13a-15 of the General Rules and Regulations under the Exchange Act) that comply with the requirements of the Exchange Act; such disclosure controls and procedures have been designed to ensure that information required to be disclosed
by the Company and its Subsidiaries is accumulated and communicated to the Company’s management, including the Company’s principal executive officer and principal financial officer by others within those entities, such disclosure controls
and procedures are effective. 
 (bb) Sarbanes-Oxley Act. The Company is in compliance in all material respects with
any and all applicable requirements of the Sarbanes-Oxley Act of 2002 that are effective as of the date hereof, and any and all applicable rules and regulations promulgated by the SEC thereunder that are effective as of the date hereof. 

(cc) Foreign Corrupt Practices. Neither the Company nor any of its Subsidiaries nor, to the Company’s Knowledge,
any director, officer, agent, employee or other Person acting on behalf of the Company or any of its Subsidiaries has, in the course of its actions for, or on behalf of, the Company (i) used any corporate funds for any unlawful contribution,
gift, entertainment or other unlawful expenses relating to political activity; (ii) made any direct or indirect unlawful payment to any foreign or domestic government official or employee from corporate funds; or (iii) violated or is in
violation of any provision of the U.S. Foreign Corrupt Practices Act of 1977, as amended. 

  
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 (dd) Indebtedness. Except as disclosed in the SEC Reports, neither the
Company nor any of its Subsidiaries (i) has any outstanding Indebtedness (as defined below), (ii) is in violation of any term of or in default under any contract, agreement or instrument relating to any Indebtedness, except where such
violations and defaults would not result, individually or in the aggregate, in a Material Adverse Effect, or (iii) is a party to any contract, agreement or instrument relating to any Indebtedness, the performance of which, in the judgment of
the Company’s officers, has or is expected to have a Material Adverse Effect. For purposes of this Agreement: (x) “Indebtedness” of any Person means, without duplication (A) all indebtedness for borrowed money,
(B) all obligations issued, undertaken or assumed as the deferred purchase price of property or services (other than trade payables entered into in the ordinary course of business), (C) all reimbursement or payment obligations with respect
to letters of credit, surety bonds and other similar instruments, (D) all obligations evidenced by notes, bonds, debentures or similar instruments, including obligations so evidenced incurred in connection with the acquisition of property,
assets or businesses, (E) all indebtedness created or arising under any conditional sale or other title retention agreement, or incurred as financing, in either case with respect to any property or assets acquired with the proceeds of such
indebtedness (even though the rights and remedies of the seller or bank under such agreement in the event of default are limited to repossession or sale of such property), (F) all monetary obligations under any leasing or similar arrangement
which, in connection with generally accepted accounting principles, consistently applied for the periods covered thereby, is classified as a capital lease, (G) all indebtedness referred to in clauses (A) through (F) above secured by
(or for which the holder of such Indebtedness has an existing right, contingent or otherwise, to be secured by) any mortgage, lien, pledge, charge, security interest or other encumbrance upon or in any property or assets (including accounts and
contract rights) owned by any Person, even though the Person which owns such assets or property has not assumed or become liable for the payment of such indebtedness, and (H) all Contingent Obligations in respect of indebtedness or obligations
of others of the kinds referred to in clauses (A) through (G) above; (y) “Contingent Obligation” means, as to any Person, any direct or indirect liability, contingent or otherwise, of that Person with respect to any
indebtedness, lease, dividend or other obligation of another Person if the primary purpose or intent of the Person incurring such liability, or the primary effect thereof, is to provide assurance to the obligee of such liability that such liability
will be paid or discharged, or that any agreements relating thereto will be complied with, or that the holders of such liability will be protected (in whole or in part) against loss with respect thereto; and (z) “Person” means
an individual, a limited liability company, a partnership, a joint venture, a corporation, a trust, an unincorporated organization and a government or any department or agency thereof. 

(ee) Employee Relations. There is (i) no unfair labor practice complaint pending against the Company, or any of
its Subsidiaries, nor to the Company’s Knowledge, threatened against it or any of its Subsidiaries, before the National Labor Relations Board, any state or local labor relation board or any foreign labor relations board, and no significant
grievance or significant arbitration proceeding arising out of or under any collective bargaining agreement is so pending against the Company or any of its Subsidiaries, or, to the Company’s Knowledge, threatened against it and (ii) no
labor disturbance by the employees of the Company or any of its Subsidiaries exists or, to the Company’s Knowledge, is imminent, and the Company is not aware of any existing or imminent labor disturbance by the employees of any of its or its
Subsidiaries principal suppliers, manufacturers, customers or contractors, except for such disturbances which could not reasonably be expected to have, singularly or in the aggregate, a Material Adverse Effect. To the Company’s Knowledge, no
executive officer or key employee of the Company or any Subsidiary plans to terminate employment with the Company or any such Subsidiary. 

(ff) Labor Matters. The Company and its Subsidiaries are in compliance in all material respects with all federal,
state, local and foreign laws and regulations respecting labor, 

  
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employment and employment practices and benefits, terms and conditions of employment and wages and hours, except where failure to be in compliance would not, either individually or in the
aggregate, reasonably be expected to result in a Material Adverse Effect. 
 (gg) Environmental Laws. The Company and
its Subsidiaries (i) are in compliance in all material respects with any and all Environmental Laws (as hereinafter defined), (ii) have received all permits, licenses or other approvals required of them under applicable Environmental Laws
to conduct their respective businesses and (iii) are in compliance in all material respects with all terms and conditions of any such permit, license or approval where, in each of the foregoing clauses (i), (ii) and (iii), the failure to
so comply would be reasonably expected to have, individually or in the aggregate, a Material Adverse Effect. The term “Environmental Laws” means all federal, state, local or foreign laws relating to pollution or protection of human health
or the environment (including, without limitation, ambient air, surface water, groundwater, land surface or subsurface strata), including, without limitation, laws relating to emissions, discharges, releases or threatened releases of chemicals,
pollutants, contaminants, or toxic or hazardous substances or wastes (collectively, “Hazardous Materials”) into the environment, or otherwise relating to the manufacture, processing, distribution, use, treatment, storage, disposal,
transport or handling of Hazardous Materials, as well as all authorizations, codes, decrees, demands or demand letters, injunctions, judgments, licenses, notices or notice letters, orders, permits, plans or regulations issued, entered, promulgated
or approved thereunder. 
 (hh) Tax Status. The Company and each of its Subsidiaries (i) has made or filed all
foreign, federal and state income and all other tax returns, reports and declarations required by any jurisdiction to which it is subject, (ii) has paid all taxes and other governmental assessments and charges that are material in amount, shown
or determined to be due on such returns, reports and declarations, except those being contested in good faith and (iii) has set aside on its books provision reasonably adequate for the payment of all taxes for periods subsequent to the periods
to which such returns, reports or declarations apply, except in those, in each of the cases described in clauses (i), (ii) and (iii) of this paragraph (hh), that would not, singularly or in the aggregate, have a Material Adverse Effect.
There are no unpaid taxes in any material amount claimed to be due by the taxing authority of any jurisdiction, and the officers of the Company know of no basis for any such claim. 

(ii) U.S. Real Property Holding Corporation. The Company is not, nor has it ever been, a U.S. real property holding
corporation within the meaning of Section 897 of the Internal Revenue Code of 1986, as amended, and the Company shall so certify upon any Investor’s request. 

(jj) Bank Holding Company Act. Neither the Company nor any of its Subsidiaries is subject to the Bank Holding Company
Act of 1956, as amended (the “BHCA”) and to regulation by the Board of Governors of the Federal Reserve System (the “Federal Reserve”). Neither the Company nor any of its Subsidiaries or affiliates owns or controls,
directly or indirectly, five percent (5%) or more of the outstanding shares of any class of voting securities or twenty-five percent (25%) or more of the total equity of a bank or any equity that is subject to the BHCA and to regulation by
the Federal Reserve. Neither the Company nor any of its Subsidiaries or affiliates exercises a controlling influence over the management or policies of a bank or any entity that is subject to the BHCA and to regulation by the Federal Reserve. 

(kk) Shell Company Status. The Company is not, and has never been, an issuer identified in Rule 144(i)(1). 

  
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 (ll) Manipulation of Price. The Company has not, and to the
Company’s Knowledge no one acting on its behalf has, (i) taken, directly or indirectly, any action designed to cause or to result, or that could reasonably be expected to cause or result, in the stabilization or manipulation of the price
of any security of the Company to facilitate the sale or resale of any of the Securities, (ii) other than the Agents, sold, bid for, purchased, or paid any compensation for soliciting purchases of, any of the Securities, or (iii) other
than the Agents, paid or agreed to pay to any person any compensation for soliciting another to purchase any other securities of the Company. 

(mm) FDA. The Company and each of its Subsidiaries have operated and currently are in compliance with all applicable
rules and regulations of the FDA or any other federal, state, local or foreign governmental body exercising comparable authority, except where the failure to so operate or be in compliance would not have a Material Adverse Effect. All preclinical
and clinical studies conducted by or, to the Company’s Knowledge, on behalf of the Company to support approval for commercialization of the Company’s products have been conducted by the Company, or to the Company’s Knowledge by third
parties, in compliance with all applicable federal, state or foreign laws, rules, orders and regulations, except for such failure or failures to be in compliance which could not reasonably be expected to have, singly or in the aggregate, a Material
Adverse Effect. The descriptions of the tests and preclinical and clinical studies, and results thereof, conducted by or, to the Company’s Knowledge, on behalf of the Company contained in the SEC Reports are accurate and complete in all
material respects; and the Company has not received any oral or written notice or correspondence from the FDA or any foreign, state or local governmental body exercising comparable authority requiring the termination, suspension, or clinical hold of
any tests or preclinical or clinical studies, or such written notice or correspondence from any Institutional Review Board or comparable authority requiring the termination or suspension of a clinical study, conducted by or on behalf of the Company,
which termination, suspension, or clinical hold would reasonably be expected to have a Material Adverse Effect. 
 3.2 Representations,
Warranties and Covenants of the Investors. Each Investor hereby, as to itself only and for no other Investor, represents, warrants and covenants to the Company and the Agents as follows: 

(a) Organization; Authority. Such Investor is an entity duly organized, validly existing and in good standing under the
laws of the jurisdiction of its organization with the requisite corporate, partnership or other power and authority to enter into and to consummate the transactions contemplated by the Transaction Documents and otherwise to carry out its obligations
hereunder and thereunder. The purchase by such Investor of the Securities hereunder has been duly authorized by all necessary corporate, partnership or other action on the part of such Investor. This Agreement has been duly executed and delivered by
such Investor and constitutes the valid and binding obligation of such Investor, enforceable against it in accordance with its terms, except as may be limited by (i) applicable bankruptcy, insolvency, reorganization or other laws of general
application relating to or affecting the enforcement of creditors rights generally, and (ii) the effect of rules of law governing the availability of specific performance and other equitable remedies. 

(b) No Public Sale or Distribution. Such Investor is acquiring the Securities in the ordinary course of business for
its own account and not with a view towards, or for resale in connection with, the public sale or distribution thereof, except pursuant to sales registered under the Securities Act or under an exemption from such registration and in compliance with
applicable federal and state securities laws, and such Investor does not have a present arrangement to effect any distribution of the Securities to or through any person or entity; provided, however, that by making the representations
herein, such Investor does not agree to hold any of the Securities for any minimum or other specific term and reserves the right to dispose of the Securities at any time in accordance with or pursuant to a registration statement or an exemption
under the Securities Act and pursuant to the applicable terms of the Transaction Documents). 

  
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 (c) Investor Status. At the time such Investor was offered the
Securities, it was, and at the date hereof it is, (i) an “accredited investor” as defined in Rule 501(a) under the Securities Act and (ii) either (A) an “institutional investor” as defined in Financial Industry
Regulatory Authority Rule 5110(d)(4)(B) or, (B) if the Investor is not an entity, a “qualified purchaser” as defined in Section 2(a)(51)(A)(i) of the Investment Company Act of 1940, as amended. Such Investor is not a registered
broker dealer registered under Section 15(a) of the Exchange Act, or a member of the Financial Industry Regulatory Authority, Inc. or an entity engaged in the business of being a broker dealer. Except as otherwise disclosed in writing to the
Company on Exhibit B-2 (attached hereto) on or prior to the date of this Agreement, such Investor is not affiliated with any broker dealer registered under Section 15(a) of the Exchange Act, or a member of the Financial Industry Regulatory
Authority, Inc. or an entity engaged in the business of being a broker dealer. After giving effect to the purchase of Common Shares hereunder, such Investor, together with its Affiliates, will not beneficially own more than 19.9% of the
Company’s outstanding Common Stock or voting power. Such Investor maintains is principal executive office at the location specified in Exhibit A. 

(d) Experience of Such Investor. Such Investor, either alone or together with its representatives has such knowledge,
sophistication and experience in business and financial matters so as to be capable of evaluating the merits and risks of the prospective investment in the Securities, and has so evaluated the merits and risks of such investment. Such Investor
understands that it must bear the economic risk of this investment in the Securities indefinitely, and is able to bear such risk and is able to afford a complete loss of such investment. 

(e) Access to Information. Such Investor acknowledges that it has reviewed the Disclosure Materials and has been
afforded: (i) the opportunity to ask such questions as it has deemed necessary of, and to receive answers from, the Company and its representatives concerning the terms and conditions of the offering of the Securities and the merits and risks
of investing in the Securities; (ii) access to information (other than material non-public information) about the Company and the Subsidiaries and their respective financial condition, results of operations, business, properties, management and
prospects sufficient to enable it to evaluate its investment; and (iii) the opportunity to obtain such additional information that the Company possesses or can acquire without unreasonable effort or expense that is necessary to make an informed
investment decision with respect to the investment. Neither such inquiries nor any other investigation conducted by or on behalf of such Investor or its representatives or counsel shall modify, amend or affect such Investor’s right to rely on
the truth, accuracy and completeness of the Disclosure Materials and the Company’s representations and warranties contained in the Transaction Documents. Such Investor acknowledges that either it has access to the SEC Reports or has received
copies of the SEC Reports. 
 (f) General Solicitation. Such Investor is not purchasing the Securities as a result of
any advertisement, article, notice or other communication regarding the Securities published in any newspaper, magazine or similar media, broadcast over television or radio, disseminated over the Internet or presented at any seminar or, to its
knowledge, any other general solicitation or general advertisement. 
 (g) No Governmental Review. Such Investor
understands that no United States federal or state agency or any other government or governmental agency has passed on or made any recommendation or endorsement of the Securities or the fairness or suitability of the investment in the Securities nor
have such authorities passed upon or endorsed the merits of the offering of the Securities. 

  
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 (h) No Conflicts. The execution, delivery and performance by such
Investor of this Agreement and the consummation by such Investor of the transactions contemplated hereby will not (i) result in a violation of the organizational documents of such Investor or (ii) conflict with, or constitute a default (or
an event which with notice or lapse of time or both would become a default) under, or give to others any rights of termination, amendment, acceleration or cancellation of, any agreement, indenture or instrument to which such Investor is a party, or
(iii) result in a violation of any law, rule, regulation, order, judgment or decree (including federal and state securities laws) applicable to such Investor, except in the case of clauses (ii) and (iii) above, for such that are not
material and do not otherwise affect the ability of such Investor to consummate the transactions contemplated hereby. 
 (i)
Prohibited Transactions. No Investor, directly or indirectly, and no Person acting on behalf of or pursuant to any understanding with any Investor, has engaged in any purchases or sales of any securities, including any derivatives, of the
Company (including, without limitation, any Short Sales involving any of the Company’s securities) (a “Transaction”) since the time that such Investor was first contacted by the Company, the Agents or any other Person regarding
an investment in the Company. Such Investor covenants that neither it nor any Person acting on its behalf or pursuant to any understanding with such Investor will engage, directly or indirectly, in any Transactions prior to the time the transactions
contemplated by this Agreement are publicly disclosed. “Short Sales” include, without limitation, all “short sales” as defined in Rule 200 promulgated under Regulation SHO under the Exchange Act and all types of direct and
indirect stock pledges, forward sale contracts, options, puts, calls, short sales, swaps, derivatives and similar arrangements (including on a total return basis), and sales and other transactions through non-U.S. broker-dealers or foreign regulated
brokers. 
 (j) Restricted Securities. The Investors understand that the Securities are characterized as
“restricted securities” under the U.S. federal securities laws inasmuch as they are being acquired from the Company in a transaction not involving a public offering and that under such laws and applicable regulations such securities may be
resold without registration under the Securities Act only in certain limited circumstances. 
 (k) Legends. It is
understood that, except as provided in Section 4.1(b) of this Agreement, the Securities represented by the book-entry statements shall bear the legend set forth in Section 4.1(b). 

(l) No Legal, Tax or Investment Advice. Such Investor understands that nothing in this Agreement or any other materials
presented by or on behalf of the Company to the Investor in connection with the purchase of the Securities constitutes legal, tax or investment advice. Such Investor has consulted such legal, tax and investment advisors as it, in its sole
discretion, has deemed necessary or appropriate in connection with its purchase of the Securities. Such Investor understands that the Agents have acted solely as the agents of the Company in this placement of the Securities and not to the Investor,
and that the Agents make no representation or warranty with regard to the merits of this transaction or as to the accuracy of any information such Investor may have received in connection therewith. Such Investor acknowledges that he has not relied
on any information or advice furnished by or on behalf of the Agents. 
 (m) Brokers and Finders. No Person will
have, as a result of the transactions contemplated by this Agreement, any valid right, interest or claim against or upon the Company or any Investor for any commission, fee or other compensation pursuant to any agreement, arrangement or
understanding entered into by or on behalf of the Investor. 

  
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 (n) Reliance on Exemptions. Such Investor understands that the
Securities being offered and sold to it in reliance on specific exemptions from the registration requirements of United States federal and state securities laws and that the Company is relying in part upon the truth and accuracy of, and such
Investor’s compliance with, the representations, warranties, agreements, acknowledgements and understandings of such Investor set forth herein in order to determine the availability of such exemptions and the eligibility of such Investor to
acquire the Securities. 
 (o) Regulation M. Such Investor is aware that the anti-manipulation rules of
Regulation M under the Exchange Act may apply to sales of Common Stock and other activities with respect to the Common Stock by the Investors. 

ARTICLE IV 
 OTHER AGREEMENTS OF
THE PARTIES 
 4.1 Transfer Restrictions. 

(a) The Investors covenant that the Securities will only be disposed of pursuant to an effective registration statement under,
and in compliance with the requirements of, the Securities Act or pursuant to an available exemption from the registration requirements of the Securities Act, and in compliance with any applicable state securities laws. In connection with any
transfer of Securities other than pursuant to an effective registration statement or Rule 144, the Company may require the transferor to provide to the Company an opinion of counsel selected by the transferor, the form and substance of which opinion
shall be reasonably satisfactory to the Company, to the effect that such transfer does not require registration under the Securities Act. Notwithstanding the foregoing, the Company hereby consents to and agrees to register on the books of the
Company and with its Transfer Agent, without any such legal opinion, except to the extent that the Transfer Agent requests such legal opinion, any transfer of Securities by an Investor to an Affiliate of such Investor, provided, that
the transferee certifies to the Company that it is an “accredited investor” as defined in Rule 501(a) under the Securities Act and provided, that such Affiliate does not request any removal of any existing legends on any
“book-entry” evidencing the Securities. 
 (b) The Investors agree that the Securities represented by the
book-entry statements shall bear the following legend, until no longer required by this Section 4.1(b): 
 THESE SECURITIES HAVE
NOT BEEN REGISTERED WITH THE SECURITIES AND EXCHANGE COMMISSION OR THE SECURITIES COMMISSION OF ANY STATE IN RELIANCE UPON AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY
APPLICABLE STATE SECURITIES LAWS AND, ACCORDINGLY, MAY NOT BE OFFERED OR SOLD EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM, OR IN A TRANSACTION NOT SUBJECT TO, THE
REGISTRATION REQUIREMENTS OF THE SECURITIES ACT AND IN COMPLIANCE WITH APPLICABLE STATE SECURITIES LAWS OR BLUE SKY LAWS. 
 In addition, if
any Investor is an Affiliate of the Company, the Securities represented by the book-entry statements for such Investor shall bear a customary “affiliates” legend. 

  
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 At the written request of a holder of the Securities, the Company shall instruct the Transfer
Agent to remove the legend set forth above from any Securities represented by the book-entry statement for such holder, if, unless otherwise required by state securities laws, (i) once a Registration Statement covering the Securities has been
declared effective by the SEC, the holder provides to the Company and the Transfer Agent the Undertaking attached as Annex A to the Transfer Agent Instructions, (ii) in connection with a sale, assignment or other transfer, such holder provides
the Company with an opinion of counsel, the form and substance of which opinion shall be reasonably acceptable to the Company, that the sale, assignment or transfer of the Securities may be made without registration under the applicable requirements
of the Securities Act or (iii) such holder provides the Company with reasonable assurance that the Securities have been sold under Rule 144. If the Transfer Agent shall fail for any reason or for no reason to note the removal of the legend and
to deliver the Securities sold by such holder by electronic delivery at the applicable balance account of The Depository Trust Company within three (3) Trading Days after the holder has provided reasonable evidence to the Company of the
occurrence of any of (i) through (iii) above (the date such evidence is provided to the Company, the “Removal Date”), and if on or after such Trading Day the holder purchases (in an open market transaction or otherwise)
Common Shares to deliver in satisfaction of a sale by the holder of such Securities that the holder anticipated receiving without legend from the Company (a “Buy-In”), then the Company shall, within three (3) Business Days
after the holder’s request and in the holder’s discretion, either (i) pay cash to the holder in an amount equal to the holder’s total purchase price (including brokerage commissions, if any) for the Common Shares so purchased
(the “Buy-In Price”), at which point the Company’s obligation to deliver such unlegended Securities shall terminate, or (ii) promptly honor its obligation to deliver to the holder such unlegended Securities as provided
above and pay cash to the holder in an amount equal to the excess (if any) of the Buy-In Price over the product of (A) such number of Common Shares, times (B) the Closing Price on the Removal Date. Further, the Company shall, at its sole
expense, cause its legal counsel or other counsel satisfactory to the Transfer Agent (i) to provide a written confirmation to the Transfer Agent in the form of Exhibit I to the Transfer Agent Instructions and (ii) provide all opinions as
may reasonably be required by the Transfer Agent in connection with the removal of legends; provided, however, that the holder has complied with the requirements of this Section 4(b). The Company shall bear all Transfer
Agent expenses in connection with any removal of legends in accordance with this Section 4(b). 
 (c) The Company will not object to
and shall permit (except as prohibited by law) an Investor to pledge or grant a security interest in some or all of the Securities in connection with a bona fide margin agreement or other loan or financing arrangement secured by the Securities, and
if required under the terms of such agreement, loan or arrangement, the Company will not object to and shall permit (except as prohibited by law) such Investor to transfer pledged or secured Securities to the pledgees or secured parties. Except as
required by law, such a pledge or transfer would not be subject to approval of the Company, no legal opinion of the pledgee, secured party or pledgor shall be required in connection therewith, and no notice shall be required of such pledge. Each
Investor acknowledges that the Company shall not be responsible for any pledges relating to, or the grant of any security interest in, any of the Securities or for any agreement, understanding or arrangement between any Investor and its pledgee or
secured party. Provided that the Company is in compliance with the terms of this Section 4.1(c), the Company’s indemnification obligations pursuant to Section 6.4 shall not extend to any Proceeding or Losses arising out
of or related to this Section 4.1(c). 
 4.2 Furnishing of Information. Until the date that any Investor owning Common
Shares may sell all of them without restriction or limitation under Rule 144 of the Securities Act (or any successor provision) (including, without limitation, the requirement to be in compliance with Rule 144(c)(1)), the Company covenants to use
its commercially reasonable efforts to timely file (or obtain extensions in respect thereof and file within the applicable grace period) all reports required to be filed by the Company after the date hereof pursuant to the Exchange Act. 

  
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 4.3 Integration. The Company shall not, and shall use its commercially reasonably efforts
to ensure that no Affiliate thereof shall, sell, offer for sale or solicit offers to buy or otherwise negotiate in respect of any security (as defined in Section 2 of the Securities Act) that would be integrated with the offer or sale of the
Securities in a manner that would require the registration under the Securities Act of the sale of the Securities to the Investors or that would be integrated with the offer or sale of the Securities for purposes of the rules and regulations of any
Trading Market. 
 4.4 Securities Laws Disclosure; Publicity. The Company shall (i) on or before 8:30 a.m., New York time, on
the first Trading Day following execution of this Agreement, issue a press release describing the sale of the Securities contemplated hereby and (ii) file a Current Report on Form 8-K with the SEC (the “8-K Filing”) describing
all material terms of the transactions contemplated by the Transaction Documents and including as exhibits to such Current Report on Form 8-K the Transaction Documents (including the schedules and the names, and addresses of the Investors and the
amount(s) of Securities respectively purchased), in the form and at the time required by the Exchange Act. Except as herein provided (including in any Registration Statement registering the Registrable Securities for resale), the Company shall not
publicly disclose the name of any Investor, or include the name of any Investor in any press release without the prior written consent of such Investor, unless otherwise required by law. Following the 8-K Filing, no Investor shall be in possession
of material non-public information pertaining to the Company which information was delivered to the Investor by the Company or its agents or Affiliates, unless such Investor received additional information from the Company pursuant to a separate
non-disclosure agreement. 
 4.5 Use of Proceeds. The Company intends to use the net proceeds from the sale of the Securities for
working capital and general corporate purposes. The Company also may use a portion of the net proceeds, currently intended for general corporate purposes, to acquire or invest in technologies, products or services that complement its business,
although the Company has no present plans or commitments and is not currently engaged in any material negotiations with respect to these types of transactions. Pending these uses, the Company intends to invest the net proceeds from this offering in
short-term, interest-bearing, investment-grade securities, or as otherwise pursuant to the Company’s customary investment policies. 

4.6 Form D and Blue Sky. The Company shall file a Form D with respect to the Securities as required under Regulation D. The Company, on
or before the Closing Date, shall take such action as the Company shall reasonably determine is necessary in order to obtain an exemption for or to qualify the Securities for sale to the Investors at the Closing pursuant to this Agreement under
applicable securities or “Blue Sky” laws of the states of the United States (or to obtain an exemption from such qualification), and shall provide evidence of any such action so taken to the Investors on or prior to the Closing Date. The
Company shall make all filings and reports relating to the offer and sale of the Securities required under applicable securities or “Blue Sky” laws of the states of the United States following the Closing Date. 

ARTICLE V 
 CONDITIONS 

5.1 Conditions Precedent to the Obligations of the Investors. The obligation of each Investor to acquire Securities at the Closing is
subject to the satisfaction or waiver by such Investor, at or before the Closing, of each of the following conditions: 

(a) Representations and Warranties. The representations and warranties of the Company contained herein shall be true
and correct in all material respects (except for those representations and warranties which are qualified by materiality or Material Adverse Effect, which shall be true and correct in all respects) as of the date when made and as of the Closing as
though made on and as of such date (except for representations and warranties that speak as of a specific date, which 

  
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shall be true and correct in all material respects as of such specified date (except for those representations and warranties which are qualified by materiality or Material Adverse Effect, which
shall be true and correct in all respects as of such specified date)); and 
 (b) Performance. The Company and each
other Investor shall have performed, satisfied and complied in all material respects with all covenants, agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with by it at or prior to the Closing.

 (c) No Injunction. No statute, rule, regulation, executive order, decree, ruling or injunction shall have been
enacted, entered, promulgated or endorsed by any court or governmental authority of competent jurisdiction that prohibits the consummation of any of the transactions contemplated by the Transaction Documents. 

(d) Listing. The Company shall have submitted a Listing of Additional Shares Notification with the NASDAQ Capital
Market covering all of the Securities. 
 (e) Company Deliverables. The Company shall have delivered the Company
Deliverables in accordance with Section 2.2(a). 
 (f) Compliance Certificate. The Company shall have
delivered to each Investor a certificate, dated as of the Closing Date and signed by its Chief Executive Officer or its Chief Financial Officer, dated as of the Closing Date, certifying to the fulfillment of the conditions specified in
Sections 5.1(a) and (b) in the form attached hereto as Exhibit F. 
 (g)
Termination. This Agreement shall not have been terminated as to such Investor in accordance with Section 7.1. 
 5.2
Conditions Precedent to the Obligations of the Company. The obligation of the Company to sell the Securities at the Closing is subject to the satisfaction or waiver by the Company, at or before the Closing, of each of the following
conditions: 
 (a) Representations and Warranties. The representations and warranties of the Investors contained
herein shall be true and correct in all material respects (except for those representations and warranties which are qualified by materiality or Material Adverse Effect, which shall be true and correct in all respects) as of the date when made and
as of the Closing Date as though made on and as of such date (except for representations and warranties that speak as of a specific date, which shall be true and correct in all material respects as of such specified date (except for those
representations and warranties which are qualified by materiality or Material Adverse Effect, which shall be true and correct in all respects as of such specified date)); and 

(b) Performance. The Investors shall have performed, satisfied and complied in all material respects with all
covenants, agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with by the Investors at or prior to the Closing. 

(c) No Injunction. No statute, rule, regulation, executive order, decree, ruling or injunction shall have been enacted,
entered, promulgated or endorsed by any court or governmental authority of competent jurisdiction that prohibits the consummation of any of the transactions contemplated by the Transaction Documents 

  
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 (d) Purchase Price. The Investors shall have paid the purchase price to
the Company in accordance with Section 2.2(a). 
 (e) “Bad Actor” Certifications. Each Insider
shall have provided to the Company an Insider Certification in the form of Exhibit G hereto prior to the date hereof and on or prior to the Closing Date the Agents shall have provided to the Company evidence reasonably satisfactory to the Company
and its counsel that (A) none of the Agents is subject to any “bad actor” disqualification specified in Rule 506(d) of Regulation D, and (B) prior to the Closing Date the Agents have complied with the “bad actor”
disclosure requirements set forth in Rule 506(e) of Regulation D. 
 (f) Termination. This Agreement shall not
have been terminated as to the Company in accordance with Section 7.1. 
 ARTICLE VI 

REGISTRATION RIGHTS 
 6.1
Registration Statement. 
 (a) As promptly as possible, and in any event on or prior to the Initial Filing Date, the
Company shall prepare and file with the SEC a Registration Statement covering the resale of all Registrable Securities for an offering to be made on a continuous basis pursuant to Rule 415. The Registration Statement shall be on Form S-1 and shall
contain (except if otherwise directed by the Investors or requested by the SEC) the “Plan of Distribution” in substantially the form attached hereto as Exhibit D. To the extent the staff of the SEC (the “Staff”)
does not permit pursuant to the SEC Guidance all of the Registrable Securities to be registered on the initial Registration Statement filed pursuant to this Section 6.1(a) (the “Initial Registration Statement”) or
requires any Investor to be named as an “underwriter”, then the Company shall use its commercially reasonable efforts to persuade the Staff that the offering contemplated by the Registration Statement is a valid secondary offering and not
an offering “by or on behalf of the issuer” as defined in Rule 415 and that none of the Investors is an “underwriter”; provided, however, that in no event shall the Company be required to continue discussions with
the Staff if the Company reasonably determines that doing so is reasonably likely to cause the Company to incur liquidated damages pursuant to Section 6.1(d) because of a failure to have the Initial Registration Statement declared
effective prior to the Initial Required Effectiveness Date. In the event that, despite the Company’s commercially reasonable efforts and compliance with the terms of this Section 6.1(a), the Staff refuses to alter its position, the
Company shall (i) remove from the Registration Statement such portion of the Registrable Securities (the “Cut Back Shares”) and/or (ii) agree to such restrictions and limitations on the registration and resale of the
Registrable Securities as the Staff may require to assure the Company’s compliance with the requirements of Rule 415 (collectively, the “SEC Restrictions”); provided, however, that the Company shall not agree to
name any Investor as an “underwriter” in such Registration Statement without the prior written consent of such Investor; provided, further, that if any such Investor refuses to be named as an underwriter as required by the
SEC Restrictions, such Investor’s Registrable Securities shall be removed from the Initial Registration Statement and such Registrable Securities shall be deemed to constitute Cut Back Shares and the provisions of Section 6.1(m)
shall apply to such Cut Back Shares. Except as provided in the immediately preceding sentence, any cut-back imposed pursuant to this Section 6.1(a) shall be allocated among the Investors on a pro rata basis, unless the SEC Restrictions
otherwise require or provide or the Investors otherwise agree. In furtherance of the foregoing, upon the reasonable request of the Company, each Investor shall promptly provide the Company with sufficient information relating to

  
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its sales of Registrable Securities so as to enable the Company to determine whether it can file one or more additional registration statements covering the Cut Back Shares and the Company agrees
that it shall file one or more additional Registration Statements (each an “Additional Registration Statement”), as promptly as possible, and in any event on or prior to the Additional Filing Date, successively using its
commercially reasonable efforts to register on each such Additional Registration Statement the maximum number of remaining Cut Back Shares that continue to constitute Registrable Securities until all of the Registrable Securities have been
registered with the SEC. 
 (b) The Company shall use its commercially reasonable efforts to cause each Registration
Statement to be declared effective by the SEC as promptly as practicable after the filing thereof, but in any event prior to the applicable Required Effectiveness Date, and shall use its commercially reasonable efforts to keep the Registration
Statement continuously effective under the Securities Act until the earliest of (i) the date that all Registrable Securities covered by such Registration Statement have been sold, (ii) the date that all the Registrable Securities covered
by such Registration Statement can be sold publicly without restriction or limitation under Rule 144 (including, without limitation, the requirement to be in compliance with Rule 144(c)(1)) or (iii) the date that is two (2) years following
the Closing Date (the period ending on the earliest of such dates, the “Effectiveness Period”). Not later than two Trading Days after a Registration Statement is declared effective, the Company shall file a prospectus supplement for
any Registration Statement to the extent required pursuant to Rule 424. 
 (c) The Company shall notify the Investors in
writing promptly (and in any event within two Trading Days) after receiving notification from the SEC that a Registration Statement has been declared effective. 

(d) Should an Event (as defined below) occur, then upon the occurrence of such Event and on every monthly anniversary thereof
until the applicable Event is cured, the Company shall pay to each Investor an amount in cash, as liquidated damages and not as a penalty, equal to one percent (1.0%) of the aggregate Purchase Price of the Registrable Securities then held by
the Investor; provided, however, that the total amount of payments pursuant to this Section 6.1(d) shall not exceed, when aggregated with all such payments paid to all Investors, ten percent (10%) of the aggregate
Purchase Price hereunder. The payments to which an Investor shall be entitled pursuant to this Section 6.1(d) are referred to herein as “Event Payments.” Any Event Payments payable pursuant to the terms hereof shall
apply on a pro rated basis for any portion of a month prior to the cure of an Event. In the event the Company fails to make Event Payments in a timely manner, such Event Payments shall bear interest at the rate of one percent (1.0%) per month
(prorated for partial months) until paid in full. All pro rated calculations made pursuant to this paragraph shall be based upon the actual number of days in such pro rated month. The parties agree that the Company will not be liable for liquidated
damages under this Section 6.1(d) with respect to (1) any period after the expiration of the Effectiveness Period, and (2) as to any Cut Back Shares which are not permitted by the SEC to be included in a Registration Statement
due solely to SEC Guidance or the SEC Restrictions from the time that it is determined that such Cut Back Shares are not permitted to be registered so long as not due to any action taken by the Company to register shares that are not Registrable
Securities. In such case, the Event Payments shall be calculated to only apply to the percentage of Registrable Securities which are permitted in accordance with SEC Guidance to be included in such Registration Statement. In the event that the
Company registers some but not all of the Registrable Securities, the 1.0% of liquidated damages referred to above for any monthly period shall be reduced to equal the percentage determined by multiplying 1.0% by a fraction, the numerator of which
shall be the number of Registrable Securities for which there is not an effective Registration Statement at such time and the denominator of which shall be the number of Registrable Securities at such time. 

  
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 For such purposes, each of the following shall constitute an “Event”: 

(i) a Registration Statement is not filed on or prior to its Filing Date or is not declared effective on or prior to its Required
Effectiveness Date; and 
 (ii) except as provided for in Section 6.1(e) (the “Excluded Events”), after the
Effective Date of a Registration Statement and through the end of the Effectiveness Period, an Investor is not permitted to sell Registrable Securities under the Registration Statement (or a subsequent Registration Statement filed in replacement
thereof) for any reason (other than the fault of such Investor). 
 (e) Notwithstanding anything in this Agreement to the
contrary, the Company may, by written notice to the Investors and subject to the limits set forth below, suspend sales under a Registration Statement after the Effective Date thereof and/or require that the Investors immediately cease the sale of
shares of Common Stock pursuant thereto and/or defer the filing of any subsequent Registration Statement if the Company determines in good faith after consultation with legal counsel: (A) there exists material non-public information relating to
the Company which has not been included or incorporated by reference into the Registration Statement (“Undisclosed Information”), and (B) the public disclosure of the Undisclosed Information at that time would be materially
adverse to the best interests of the Company. Upon receipt of such notice, each Investor shall immediately discontinue any sales of Registrable Securities pursuant to such registration until such Investor is advised in writing by the Company that
the current Prospectus or amended Prospectus, as applicable, may be used. For the avoidance of doubt, however, Investors shall be permitted to settle trades of Securities where the settlement date is after the effectiveness of a suspension notice,
but only if the trade was made prior to the Investor’s receipt of the Company’s suspension notice. In no event, however, shall this right be exercised to suspend sales beyond the period during which (in the good faith determination of the
Company) (A) the Undisclosed Information is both material and non-public or (B) the failure to require such suspension would be materially detrimental to the Company. The Company’s rights under this Section 6(e) may be
exercised for a period of not more than twenty (20) consecutive Trading Days or an aggregate of forty-five (45) Trading Days in any twelve-month period (whether or not consecutive) (an “Allowed Delay”). Subject to the
foregoing limits, an Allowed Delay will not be considered an Event. Immediately after the end of any suspension period under this Section 6(e), the Company shall take all necessary actions (including filing any required supplemental
prospectus) to restore the effectiveness of the applicable Registration Statement and the ability of the Investors to publicly resell their Registrable Securities pursuant to such effective Registration Statement. 

(f) The Company shall not, from the date hereof until the Effective Date of the Initial Registration Statement, prepare and
file with the SEC a registration statement relating to an offering for its own account or the account of others under the Securities Act of any of its equity securities, other than any registration statement or post-effective amendment to a
registration statement (or supplement thereto) relating to the Company’s employee benefit plans registered on Form S-8 or, in connection with an acquisition, on Form S-4. 

6.2 Registration Procedures. In connection with the Company’s registration obligations hereunder, the Company shall: 

(a) Not less than five (5) Trading Days prior to the filing of a Registration Statement or any related Prospectus or any
amendment or supplement thereto, furnish via email to those Investors who have supplied the Company with email addresses copies of all such documents proposed to be filed, which documents (other than any document that is incorporated or deemed to be
incorporated by reference therein) will be subject to the review of such Investors. The Company shall reflect in each 

  
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such document when so filed with the SEC such comments regarding the Investors and the plan of distribution as the Investors may reasonably and promptly propose no later than two Trading Days
after the Investors have been so furnished with copies of such documents as aforesaid. 
 (b) (i) Subject to
Section 6.1(e), prepare and file with the SEC such amendments, including post-effective amendments, to each Registration Statement and the Prospectus used in connection therewith as may be necessary to keep the Registration Statement
continuously effective, as to the applicable Registrable Securities for the Effectiveness Period and prepare and file with the SEC such additional Registration Statements in order to register for resale under the Securities Act all of the
Registrable Securities; (ii) cause the related Prospectus to be amended or supplemented by any required Prospectus supplement, and as so supplemented or amended to be filed pursuant to Rule 424; and (iii) comply in all material respects
with the provisions of the Securities Act and the Exchange Act with respect to the disposition of all Registrable Securities covered by the Registration Statement during the applicable period in accordance with the intended methods of disposition by
the Investors thereof set forth in the Registration Statement as so amended or in such Prospectus as so supplemented. 
 (c)
Notify the Investors as promptly as reasonably possible, and if requested by the Investors, confirm such notice in writing no later than two Trading Days thereafter, of any of the following events: (i) the SEC notifies the Company whether there
will be a “review” of any Registration Statement; (ii) any Registration Statement or any post-effective amendment is declared effective; (iii) the SEC issues any stop order suspending the effectiveness of any Registration
Statement or initiates any Proceedings for that purpose; (vi) the Company receives notice of any suspension of the qualification or exemption from qualification of any Registrable Securities for sale in any jurisdiction, or the initiation or
threat of any Proceeding for such purpose; (iv) the financial statements included in any Registration Statement become ineligible for inclusion therein or (v) the Company becomes aware that any Registration Statement or Prospectus or other
document contains any untrue statement of a material fact or omits to state any material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading. 

(d) Use its commercially reasonable efforts to avoid the issuance of or, if issued, obtain the withdrawal of (i) any
order suspending the effectiveness of any Registration Statement, or (ii) any suspension of the qualification (or exemption from qualification) of any of the Registrable Securities for sale in any jurisdiction, as soon as possible. 

(e) If requested by an Investor, provide such Investor and Counsel to the lead investor, without charge, at least one
conformed copy of each Registration Statement and each amendment thereto, including financial statements and schedules, and all exhibits to the extent requested by such Person (including those previously furnished or incorporated by reference)
promptly after the filing of such documents with the SEC; provided, that the Company shall have no obligation to provide any document pursuant to this clause that is available on the SEC’s EDGAR system. 

(f) Promptly deliver to each Investor, without charge, as many copies of the Prospectus or Prospectuses (including each form
of prospectus) and each amendment or supplement thereto as such Persons may reasonably request. The Company hereby consents to the use of such Prospectus and each amendment or supplement thereto by each of the selling Investors in connection with
the offering and sale of the Registrable Securities covered by such Prospectus and any amendment or supplement thereto to the extent permitted by federal and state securities laws and regulations. 

(g) (i) In the time and manner required by each Trading Market on which the Common Stock is listed, prepare and file
with such Trading Market an additional shares listing application 

  
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covering all of the Registrable Securities; (ii) use commercially reasonable efforts to cause such Registrable Securities to be approved for listing on each such Trading Market as soon as
possible thereafter; (iii) if requested by any Investor, provide to such Investor evidence of such approval; and (iv) except as a result of the Excluded Events, during the Effectiveness Period, maintain the listing of such Registrable
Securities on each such Trading Market or another Eligible Market. 
 (h) Prior to any public offering of Registrable
Securities, use its commercially reasonable efforts to register or qualify or cooperate with the selling Investors in connection with the registration or qualification (or exemption from such registration or qualification) of such Registrable
Securities for offer and sale under the securities or Blue Sky laws of such jurisdictions within the United States as any Investor requests in writing, to keep each such registration or qualification (or exemption therefrom) effective for so long as
required, but not to exceed the duration of the Effectiveness Period, and to do any and all other acts or things reasonably necessary or advisable to enable the disposition in such jurisdictions of the Registrable Securities covered by a
Registration Statement; provided, however, that the Company shall not be obligated to file any general consent to service of process or to qualify as a foreign corporation or as a dealer in securities in any jurisdiction in which it is
not so qualified or to subject itself to taxation in respect of doing business in any jurisdiction in which it is not otherwise so subject. 

(i) Cooperate with the Investors to facilitate the timely delivery of a book-entry statement reflecting the transfer of the
Registrable Securities to a transferee pursuant to a Registration Statement, which book-entry statement shall be free, to the extent permitted by this Agreement and under law, of all restrictive legends, and to enable such Registrable Securities to
be in such denominations and registered in such names as any such Investors may reasonably request. 
 (j) Upon the
occurrence of any event described in Section 6.2(c)(v), as promptly as reasonably possible, prepare a supplement or amendment, including a post-effective amendment, to the Registration Statement or a supplement to the related Prospectus
or any document incorporated or deemed to be incorporated therein by reference, and file any other required document so that, as thereafter delivered, neither the Registration Statement nor such Prospectus will contain an untrue statement of a
material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading. 

(k) It shall be a condition precedent to the obligations of the Company to complete the registration pursuant to this
Agreement with respect to the Registrable Securities of any particular Investor (but not with respect to any other Investors) or to make any Event Payments set forth in Section 6.1(c) to such Investor (but not with respect to any other
Investors) that such Investor furnish to the Company the information specified in Exhibits B-1, B-2 and B-3 hereto and such other information regarding itself, the Registrable Securities and other shares of Common Stock held by
it and the intended method of disposition of the Registrable Securities held by it (if different from the Plan of Distribution set forth on Exhibit D hereto) as shall be reasonably required to effect the registration of such Registrable
Securities and shall complete and execute such documents in connection with such registration as the Company may reasonably request. 

(l) The Company shall comply with all applicable rules and regulations of the SEC under the Securities Act and the Exchange
Act, including, without limitation, Rule 172 under the Securities Act, file any final Prospectus, including any supplement or amendment thereof, with the SEC pursuant to Rule 424 under the Securities Act, promptly inform the Investors in writing if,
at any time during the Effectiveness Period, the Company does not satisfy the conditions specified in Rule 172 and, 

  
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as a result thereof, the Investors are required to make available a Prospectus in connection with any disposition of Registrable Securities and take such other actions as may be reasonably
necessary to facilitate the registration of the Registrable Securities hereunder. 
 (m) Not identify any Investor as an
underwriter without its prior written consent in any public disclosure or filing with the SEC, the Trading Market or any Eligible Market and any Investor being deemed an underwriter by the SEC shall not relieve the Company of any obligations it has
under this Agreement; provided, however, that the foregoing shall not prohibit the Company from including the disclosure found in the “Plan of Distribution” section attached hereto as Exhibit D in the Registration
Statement. In addition, and notwithstanding anything to the contrary contained herein, if the Company has received a comment by the SEC requiring an Investor to be named as an underwriter in the Registration Statement (which notwithstanding the
reasonable best efforts of the Company is not withdrawn by the SEC) and such Investor refuses to be named as an underwriter in the Registration Statement, such Investor’s Registrable Securities shall be removed from the Registration Statement,
such Registrable Securities shall be deemed to constitute Cut Back Shares and the Investor shall not be entitled to any Event Payments with respect to such Registration Statement. 

6.3 Registration Expenses. The Company shall pay all fees and expenses incident to the performance of or compliance with
Article VI of this Agreement by the Company, including without limitation (a) all registration and filing fees and expenses, including without limitation those related to filings with the SEC, any Trading Market, any required filing with
the Financial Industry Regulatory Authority by the Agents, and in connection with applicable state securities or Blue Sky laws, (b) printing expenses (including without limitation expenses of printing certificates for Registrable Securities),
(c) messenger, telephone and delivery expenses, (d) fees and disbursements of counsel for the Company, (e) fees and expenses of all other Persons retained by the Company in connection with the consummation of the transactions
contemplated by this Agreement, (f) all listing fees to be paid by the Company to the Trading Market; and (g) the reasonable legal fees of external counsel to BVF Partners L.P. and its Affiliates, not to exceed $5,000 per Registration
Statement seeking to register Registrable Securities held by any of them. 
 6.4 Indemnification 

(a) Indemnification by the Company. The Company shall, notwithstanding any termination of this Agreement, indemnify and
hold harmless each Investor, the officers, directors, partners, members, agents and employees of each of them, each Person who controls any such Investor (within the meaning of Section 15 of the Securities Act or Section 20 of the Exchange
Act) and the officers, directors, partners, members, agents and employees of each such controlling Person, to the fullest extent permitted by applicable law, from and against any and all Losses, as incurred, arising out of or relating to any
violation by the Company of the Securities Act, the Exchange Act, any state securities law, or any rule or regulation thereunder related to the offer or sale of the Registrable Securities, any untrue or alleged untrue statement of a material fact
contained in the Registration Statement, any Prospectus or any form of Company prospectus or in any amendment or supplement thereto or in any Company preliminary prospectus, or arising out of or relating to any omission or alleged omission of a
material fact required to be stated therein or necessary to make the statements therein (in the case of any Prospectus or form of prospectus or supplement thereto, in the light of the circumstances under which they were made) not misleading, except
to the extent, but only to the extent, that (A) such untrue statements, alleged untrue statements, omissions or alleged omissions are based solely upon information regarding such Investor furnished in writing to the Company by such Investor for
use therein, or to the extent that such information relates to such Investor or such Investor’s proposed method of distribution of Registrable Securities and was reviewed and expressly approved by such Investor expressly for use in the
Registration Statement, or (B) with respect to any prospectus, if 

  
 -28- 

 
the untrue statement or omission of material fact contained in such prospectus was corrected on a timely basis in the prospectus, as then amended or supplemented, if such corrected prospectus was
timely made available by the Company to the Investor, and the Investor seeking indemnity hereunder was advised in writing not to use the incorrect prospectus prior to the use giving rise to Losses. 

(b) Indemnification by Investors. Each Investor shall, severally and not jointly, indemnify and hold harmless the
Company, its directors, officers, agents and employees, each Person who controls the Company (within the meaning of Section 15 of the Securities Act and Section 20 of the Exchange Act), and the directors, officers, agents or employees of
such controlling Persons, to the fullest extent permitted by applicable law, from and against all Losses (as determined by a court of competent jurisdiction in a final judgment not subject to appeal or review) arising solely out of any untrue
statement of a material fact contained in the Registration Statement, any Prospectus, or any form of prospectus, or in any amendment or supplement thereto, or arising out of or relating to any omission of a material fact required to be stated
therein or necessary to make the statements therein (in the case of any Prospectus or form of prospectus or supplement thereto, in the light of the circumstances under which they were made) not misleading, but only to the extent that such untrue
statement or omission is contained in any information so furnished by such Investor in writing to the Company specifically for inclusion in such Registration Statement or such Prospectus or to the extent that (i) such untrue statements or
omissions are based solely upon information regarding such Investor furnished to the Company by such Investor in writing expressly for use therein, or to the extent that such information relates to such Investor or such Investor’s proposed
method of distribution of Registrable Securities and was reviewed and expressly approved by such Investor expressly for use in the Registration Statement (it being understood that the information provided by the Investor to the Company in Exhibits
B-1, B-2 and B-3 and the Plan of Distribution set forth on Exhibit D, as the same may be modified by such Investor and other information provided by the Investor to the Company in or pursuant to the Transaction Documents constitutes information
reviewed and expressly approved by such Investor in writing expressly for use in the Registration Statement), such Prospectus or such form of Prospectus or in any amendment or supplement thereto. In no event shall the liability of any selling
Investor hereunder be greater in amount than the dollar amount of the net proceeds received by such Investor upon the sale of the Registrable Securities giving rise to such indemnification obligation. 

(c) Conduct of Indemnification Proceedings. If any Proceeding shall be brought or asserted against any Person entitled
to indemnity hereunder (an “Indemnified Party”), such Indemnified Party shall promptly notify the Person from whom indemnity is sought (the “Indemnifying Party”) in writing, and the Indemnifying Party shall assume
the defense thereof, including the employment of counsel reasonably satisfactory to the Indemnified Party and the payment of all fees and expenses incurred in connection with defense thereof; provided, that the failure of any
Indemnified Party to give such notice shall not relieve the Indemnifying Party of its obligations or liabilities pursuant to this Agreement, except (and only) to the extent that it shall be finally determined by a court of competent jurisdiction
(which determination is not subject to appeal or further review) that such failure shall have proximately and materially adversely prejudiced the Indemnifying Party. 

An Indemnified Party shall have the right to employ separate counsel in any such Proceeding and to participate in the defense
thereof, but the fees and expenses of such counsel shall be at the expense of such Indemnified Party or Parties unless: (i) the Indemnifying Party has agreed in writing to pay such fees and expenses; or (ii) the Indemnifying Party shall
have failed within 45 days of receiving notification of a Proceeding from an Indemnified Party to assume the defense of such Proceeding and to employ counsel reasonably satisfactory to such Indemnified Party in any such Proceeding; or (iii) the
named parties to any such Proceeding (including any impleaded parties) include both such Indemnified Party and the Indemnifying Party, and such Indemnified Party shall have been advised by counsel that a conflict of

  
 -29- 

 
interest is likely to exist if the same counsel were to represent such Indemnified Party and the Indemnifying Party (in which case, if such Indemnified Party notifies the Indemnifying Party in
writing that it elects to employ separate counsel at the expense of the Indemnifying Party, the Indemnifying Party shall not have the right to assume the defense thereof and the reasonable fees and expenses of separate counsel shall be at the
expense of the Indemnifying Party). It being understood, however, that the Indemnifying Party shall not, in connection with any one such Proceeding (including separate Proceedings that have been or will be consolidated before a single judge) be
liable for the fees and expenses of more than one separate firm of attorneys at any time for all Indemnified Parties, which firm shall be appointed by a majority of the Indemnified Parties. The Indemnifying Party shall not be liable for any
settlement of any such Proceeding effected without its written consent, which consent shall not be unreasonably withheld. No Indemnifying Party shall, without the prior written consent of the Indemnified Party, effect any settlement of any pending
Proceeding in respect of which any Indemnified Party is a party, unless such settlement includes an unconditional release of such Indemnified Party from all liability on claims that are the subject matter of such Proceeding. 

All reasonable fees and expenses of the Indemnified Party (including reasonable fees and expenses to the extent incurred in
connection with investigating or preparing to defend such Proceeding in a manner not inconsistent with this Section) shall be paid to the Indemnified Party, as incurred, within 20 Trading Days of written notice thereof to the Indemnifying Party
(regardless of whether it is ultimately determined that an Indemnified Party is not entitled to indemnification hereunder; provided, that the Indemnifying Party may require such Indemnified Party to undertake to reimburse all such fees
and expenses to the extent it is finally judicially determined that such Indemnified Party is not entitled to indemnification hereunder). 

(d) Contribution. If a claim for indemnification under Section 6.4(a) or (b) is
unavailable to an Indemnified Party (by reason of public policy or otherwise), then each Indemnifying Party, in lieu of indemnifying such Indemnified Party, shall contribute to the amount paid or payable by such Indemnified Party as a result of such
Losses, in such proportion as is appropriate to reflect the relative fault of the Indemnifying Party and Indemnified Party in connection with the actions, statements or omissions that resulted in such Losses as well as any other relevant equitable
considerations. The relative fault of such Indemnifying Party and Indemnified Party shall be determined by reference to, among other things, whether any action in question, including any untrue or alleged untrue statement of a material fact or
omission or alleged omission of a material fact, has been taken or made by, or relates to information supplied by, such Indemnifying Party or Indemnified Party, and the parties’ relative intent, knowledge, access to information and opportunity
to correct or prevent such action, statement or omission. The amount paid or payable by a party as a result of any Losses shall be deemed to include, subject to the limitations set forth in Section 6.4(c), any reasonable attorneys’
or other reasonable fees or expenses incurred by such party in connection with any Proceeding to the extent such party would have been indemnified for such fees or expenses if the indemnification provided for in this Section was available to such
party in accordance with its terms. 
 The parties hereto agree that it would not be just and equitable if contribution
pursuant to this Section 6.4(d) were determined by pro rata allocation or by any other method of allocation that does not take into account the equitable considerations referred to in the immediately preceding paragraph. Notwithstanding
the provisions of this Section 6.4(d), no Investor shall be required to contribute, in the aggregate, any amount in excess of the amount by which the proceeds actually received by such Investor from the sale of the Registrable Securities
subject to the Proceeding exceeds the amount of any damages that such Investor has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission. No Person guilty of fraudulent misrepresentation
(within the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation. 

  
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 The indemnity and contribution agreements contained in this Section are in
addition to any liability that the Indemnifying Parties may have to the Indemnified Parties. 
 6.5 Dispositions. Each Investor
agrees that it will comply with the prospectus delivery requirements of the Securities Act as applicable to it in connection with sales of Registrable Securities pursuant to the Registration Statement and shall sell its Registrable Securities in
accordance with the Plan of Distribution set forth in the Prospectus. Each Investor further agrees that, upon receipt of a notice from the Company of the occurrence of any event of the kind described in Sections 6.2(c)(v), (vi) or
(vii), such Investor will discontinue disposition of such Registrable Securities under the Registration Statement until such Investor is advised in writing by the Company that the use of the Prospectus, or amended Prospectus, as applicable,
may be used. The Company may provide appropriate stop orders to enforce the provisions of this paragraph. Each Investor, severally and not jointly with the other Investors, agrees that the removal of the restrictive legend from certificates
representing Securities as set forth in this Section 4.1 is predicated upon the Company’s reliance that the Investor will comply with the provisions of this subsection. 

6.6 No Piggyback on Registrations. Neither the Company nor any of its security holders (other than the Investors in such capacity
pursuant hereto) may include securities of the Company in the Registration Statement other than the Registrable Securities. 
 6.7
Piggy-Back Registrations. If at any time during the Effectiveness Period there is not an effective Registration Statement covering all of the Registrable Securities and the Company shall determine to prepare and file with the SEC a
registration statement relating to an offering for its own account or the account of others under the Securities Act of any of its equity securities, other than on Form S-4 or Form S-8 (each as promulgated under the Securities Act) or their then
equivalents relating to equity securities to be issued solely in connection with any acquisition of any entity or business or equity securities issuable in connection with stock option or other employee benefit plans, then the Company shall send to
each Investor not then eligible to sell all of their Registrable Securities without restriction or limitation under Rule 144 (including, without limitation, requirement to be in compliance with Rule 144(c)(1)), written notice of such determination
and if, within ten days after receipt of such notice, any such Investor shall so request in writing, the Company shall include in such registration statement all or any part of such Registrable Securities such Investor requests to be registered.
Notwithstanding the foregoing, in the event that, in connection with any underwritten public offering, the managing underwriter(s) thereof shall impose a limitation on the number of shares of Common Stock which may be included in the Registration
Statement because, in such underwriter(s)’ judgment, marketing or other factors dictate such limitation is necessary to facilitate public distribution, then the Company shall be obligated to include in such Registration Statement only such
limited portion of the Registrable Securities with respect to which such Investor has requested inclusion hereunder as the underwriter shall permit; provided, however, that (i) the Company shall not exclude any Registrable
Securities unless the Company has first excluded all outstanding securities, the holders of which are not contractually entitled to inclusion of such securities in such Registration Statement or are not contractually entitled to pro rata inclusion
with the Registrable Securities and (ii) after giving effect to the immediately preceding proviso, any such exclusion of Registrable Securities shall be made pro rata among the Investors seeking to include Registrable Securities and the holders
of other securities having the contractual right to inclusion of their securities in such Registration Statement by reason of demand registration rights, in proportion to the number of Registrable Securities or other securities, as applicable,
sought to be included by each such Investor or other holder. If an offering in connection with which an Investor is entitled to registration under this Section 6.7 is an underwritten offering, then each Investor whose Registrable
Securities are 

  
 -31- 

 
included in such Registration Statement shall, unless otherwise agreed by the Company, offer and sell such Registrable Securities in an underwritten offering using the same underwriter or
underwriters and, subject to the provisions of this Agreement, on the same terms and conditions as other shares of Common Stock included in such underwritten offering and shall enter into an underwriting agreement in a form and substance reasonably
satisfactory to the Company and the underwriter or underwriters. Upon the effectiveness the registration statement for which piggy-back registration has been provided in this Section 6.7, any Event Payments payable to an Investor whose
Securities are included in such registration statement shall terminate. 
 ARTICLE VII 

MISCELLANEOUS 
 7.1
Termination. This Agreement may be terminated by the Company or any Investor, by written notice to the other parties, if the Closing has not been consummated by the third Business Day following the date of this Agreement; provided,
however, that the right to terminate this Agreement shall not be available to any Person whose failure to comply with its obligations under this Agreement has been the cause of or resulted in the failure of the Closing to occur on or before such
time, and provided, further, that no such termination will affect the right of any party to sue for any breach by the other party (or parties). 

7.2 Fees and Expenses. Except as expressly set forth in the Transaction Documents to the contrary, each party shall pay the fees and
expenses of its advisers, counsel, accountants and other experts, if any, and all other expenses incurred by such party incident to the negotiation, preparation, execution, delivery and performance of this Agreement. Notwithstanding the foregoing
and without limiting any right to reimbursement under Section 6.3, the Company shall reimburse BVF Partners L.P. and its Affiliates upon demand and presentation of an appropriate invoice for their reasonable legal fees of external
counsel incurred in connection with the transactions contemplated hereunder, with such fees not to exceed $10,000. The Company shall pay all Transfer Agent fees, stamp taxes and other taxes and duties levied in connection with the sale and issuance
of their applicable Securities. 
 7.3 Entire Agreement. The Transaction Documents, together with the Exhibits and Schedules thereto,
contain the entire understanding of the parties with respect to the subject matter hereof and supersede all prior agreements and understandings, oral or written, with respect to such matters, which the parties acknowledge have been merged into such
documents, exhibits and schedules. At or after the Closing, and without further consideration, the Company will execute and deliver to the Investors such further documents as may be reasonably requested in order to give practical effect to the
intention of the parties under the Transaction Documents. 
 7.4 Notices. Any and all notices or other communications or deliveries
required or permitted to be provided hereunder shall be in writing and shall be deemed given and effective on the earliest of (a) the date of transmission, if such notice or communication is delivered via facsimile or email at the facsimile
number or email address specified in this Section prior to 6:30 p.m. (New York City time) on a Trading Day, (b) the next Trading Day after the date of transmission, if such notice or communication is delivered via facsimile or email at the
facsimile number or email address specified in this Section on a day that is not a Trading Day or later than 6:30 p.m. (New York City time) on any Trading Day, (c) the Trading Day following the date of deposit with a nationally recognized
overnight courier service, or (d) upon actual receipt by the party to whom such notice is required to be given. The addresses, facsimile numbers and email addresses for such notices and communications are those set forth on the signature pages
hereof, or such other address or facsimile number as may be designated in writing hereafter, in the same manner, by any such Person. 

  
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 7.5 Amendments; Waivers. No provision of this Agreement may be waived or amended except in
a written instrument signed by the Company and the Required Investors. No waiver of any default with respect to any provision, condition or requirement of this Agreement shall be deemed to be a continuing waiver in the future or a waiver of any
subsequent default or a waiver of any other provision, condition or requirement hereof, nor shall any delay or omission of either party to exercise any right hereunder in any manner impair the exercise of any such right. 

7.6 Construction. The headings herein are for convenience only, do not constitute a part of this Agreement and shall not be deemed to
limit or affect any of the provisions hereof. The language used in this Agreement will be deemed to be the language chosen by the parties to express their mutual intent, and no rules of strict construction will be applied against any party. 

7.7 Successors and Assigns. This Agreement shall be binding upon and inure to the benefit of the parties and their successors and
permitted assigns. The Company may not assign this Agreement or any rights or obligations hereunder without the prior written consent of the Required Investors; provided, however, that no such consent shall be required in connection
with any assignment (i) occurring by operation of law in connection with any merger or consolidation to which the Company is a party, (ii) in connection with the acquisition of all or substantially all of the assets of the Company or
(iii) any other similar business combination transaction involving the Company. Any Investor may assign its rights under this Agreement to any Person to whom such Investor assigns or transfers any Securities; provided, that
(i) such transferor agrees in writing with the transferee or assignee to assign such rights, and a copy of such agreement is furnished to the Company after such assignment, (ii) the Company is furnished with written notice of (x) the
name and address of such transferee or assignee and (y) the Registrable Securities with respect to which such registration rights are being transferred or assigned, (iii) following such transfer or assignment, the further disposition of
such securities by the transferee or assignee is restricted under the Securities Act and applicable state securities laws, (iv) such transferee agrees in writing to be bound, with respect to the transferred Securities, by the provisions hereof
that apply to the “Investors” and (v) such transfer shall have been made in accordance with the applicable requirements of this Agreement and with all laws applicable thereto. 

7.8 Persons Entitled to Benefit of Agreement. This Agreement shall inure to the benefit of and be binding upon the Company and each
Investor and their respective successors and permitted assigns. Nothing expressed or mentioned in this Agreement is intended or shall be construed to give any person, other than those persons mentioned in the preceding sentence or otherwise
explicitly mentioned in this Agreement, any legal or equitable right, remedy or claim under or in respect of this Agreement, or any provisions herein contained, this Agreement and all conditions and provisions hereof being intended to be and being
for the sole and exclusive benefit of such persons and for the benefit of no other person; except that each Indemnified Party is an intended third party beneficiary of Section 6.4 and (in each case) may enforce the provisions of such
Section directly against the parties with obligations thereunder. 
 7.9 Governing Law; Venue; Waiver of Jury Trial. ALL QUESTIONS
CONCERNING THE CONSTRUCTION, VALIDITY, ENFORCEMENT AND INTERPRETATION OF THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. THE COMPANY AND INVESTORS HEREBY IRREVOCABLY SUBMIT TO THE NON-EXCLUSIVE
JURISDICTION OF THE STATE AND FEDERAL COURTS SITTING IN THE CITY OF NEW YORK, BOROUGH OF MANHATTAN FOR THE ADJUDICATION OF ANY DISPUTE BROUGHT BY THE COMPANY OR ANY INVESTOR HEREUNDER, IN CONNECTION HEREWITH OR WITH ANY TRANSACTION CONTEMPLATED
HEREBY OR DISCUSSED HEREIN (INCLUDING WITH RESPECT TO THE ENFORCEMENT OF ANY OF THE TRANSACTION DOCUMENTS), AND HEREBY IRREVOCABLY WAIVE, AND AGREE NOT TO ASSERT IN ANY SUIT, ACTION OR PROCEEDING BROUGHT BY THE COMPANY OR ANY INVESTOR, ANY CLAIM
THAT IT IS NOT 

  
 -33- 

 
PERSONALLY SUBJECT TO THE JURISDICTION OF ANY SUCH COURT, OR THAT SUCH SUIT, ACTION OR PROCEEDING IS IMPROPER. EACH PARTY HEREBY IRREVOCABLY WAIVES PERSONAL SERVICE OF PROCESS AND CONSENTS TO
PROCESS BEING SERVED IN ANY SUCH SUIT, ACTION OR PROCEEDING BY MAILING A COPY THEREOF VIA REGISTERED OR CERTIFIED MAIL OR OVERNIGHT DELIVERY (WITH EVIDENCE OF DELIVERY) TO SUCH PARTY AT THE ADDRESS IN EFFECT FOR NOTICES TO IT UNDER THIS AGREEMENT
AND AGREES THAT SUCH SERVICE SHALL CONSTITUTE GOOD AND SUFFICIENT SERVICE OF PROCESS AND NOTICE THEREOF. NOTHING CONTAINED HEREIN SHALL BE DEEMED TO LIMIT IN ANY WAY ANY RIGHT TO SERVE PROCESS IN ANY MANNER PERMITTED BY LAW. THE COMPANY AND
INVESTORS HEREBY WAIVE ALL RIGHTS TO A TRIAL BY JURY. 
 7.10 Survival. The representations and warranties, agreements and covenants
contained herein shall survive the Closing. 
 7.11 Execution. This Agreement may be executed in two or more counterparts, all of
which when taken together shall be considered one and the same agreement and shall become effective when counterparts have been signed by each party and delivered to the other party, it being understood that both parties need not sign the same
counterpart. In the event that any signature is delivered by facsimile transmission or email attachment, such signature shall create a valid and binding obligation of the party executing (or on whose behalf such signature is executed) with the same
force and effect as if such facsimile or email-attached signature page were an original thereof. 
 7.12 Severability. If any
provision of this Agreement is prohibited by law or otherwise determined to be invalid or unenforceable by a court of competent jurisdiction, the provision that would otherwise be prohibited, invalid or unenforceable shall be deemed amended to apply
to the broadest extent that it would be valid and enforceable, and the invalidity or unenforceability of such provision shall not affect the validity of the remaining provisions of this Agreement so long as this Agreement as so modified continues to
express, without material change, the original intentions of the parties as to the subject matter hereof and the prohibited nature, invalidity or unenforceability of the provision(s) in question does not substantially impair the respective
expectations or reciprocal obligations of the parties or the practical realization of the benefits that would otherwise be conferred upon the parties. The parties will endeavor in good faith negotiations to replace the prohibited, invalid or
unenforceable provision(s) with a valid provision(s), the effect of which comes as close as possible to that of the prohibited, invalid or unenforceable provision(s). 

7.13 Rescission and Withdrawal Right. Notwithstanding anything to the contrary contained in (and without limiting any similar
provisions of) the Transaction Documents, whenever any Investor exercises a right, election, demand or option owed to such Investor by the Company under a Transaction Document and the Company does not timely perform its related obligations within
the periods therein provided, then, prior to the performance by the Company of the Company’s related obligation, such Investor may rescind or withdraw, in its sole discretion from time to time upon written notice to the Company, any relevant
notice, demand or election in whole or in part without prejudice to its future actions and rights. 
 7.14 Remedies. In addition to
being entitled to exercise all rights provided herein or granted by law, including recovery of damages, each of the Investors and the Company will be entitled to seek specific performance under the Transaction Documents. The parties agree that
monetary damages may not be adequate compensation for any loss incurred by reason of any breach of obligations described in the foregoing sentence and hereby agrees to waive in any action for specific performance of any such obligation (other than
in connection with any action for temporary restraining order) the defense that a remedy at law would be adequate. 

  
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 7.15 Payment Set Aside. To the extent that the Company makes a payment or payments to any
Investor hereunder or any Investor enforces or exercises its rights hereunder or thereunder, and such payment or payments or the proceeds of such enforcement or exercise or any part thereof are subsequently invalidated, declared to be fraudulent or
preferential, set aside, recovered from, disgorged by or are required to be refunded, repaid or otherwise restored to the Company by a trustee, receiver or any other person under any law (including, without limitation, any bankruptcy law, state or
federal law, common law or equitable cause of action), then to the extent of any such restoration the obligation or part thereof originally intended to be satisfied shall be revived and continued in full force and effect as if such payment had not
been made or such enforcement or setoff had not occurred. 
 7.16 Adjustments in Share Numbers and Prices. In the event of any stock
split, subdivision, dividend or distribution payable in shares of Common Stock (or other securities or rights convertible into, or entitling the holder thereof to receive directly or indirectly shares of Common Stock), combination or other similar
recapitalization or event occurring after the date hereof and prior to the Closing, each reference in any Transaction Document to a number of shares or a price per share shall be amended to appropriately account for such event. 

7.17 Independent Nature of Investors’ Obligations and Rights. The obligations of each Investor under any Transaction Document are
several and not joint with the obligations of any other Investor, and no Investor shall be responsible in any way for the performance of the obligations of any other Investor under any Transaction Document. The decision of each Investor to purchase
Securities pursuant to this Agreement has been made by such Investor independently of any other Investor and independently of any information, materials, statements or opinions as to the business, affairs, operations, assets, properties,
liabilities, results of operations, condition (financial or otherwise) or prospects of the Company which may have been made or given by any other Investor or by any agent or employee of any other Investor, and no Investor or any of its agents or
employees shall have any liability to any other Investor (or any other person) relating to or arising from any such information, materials, statements or opinions. Nothing contained herein or in any Transaction Document, and no action taken by any
Investor pursuant thereto, shall be deemed to constitute the Investors as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that the Investors are in any way acting in concert or as a group with
respect to such obligations or the transactions contemplated by the Transaction Document. Each Investor acknowledges that no other Investor has acted as agent for such Investor in connection with making its investment hereunder and that no other
Investor will be acting as agent of such Investor in connection with monitoring its investment hereunder. Each Investor shall be entitled to independently protect and enforce its rights, including without limitation the rights arising out of this
Agreement or out of the other Transaction Documents, and it shall not be necessary for any other Investor to be joined as an additional party in any proceeding for such purpose. 

[SIGNATURE PAGES TO FOLLOW] 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Securities Purchase Agreement to be duly
executed by their respective authorized signatories as of the date first indicated above. 
  

			
	REGADO BIOSCIENCES, INC.
		
	By:	 	  

	Name:	 	
	Title:	 	
	
	Address for Notice:
	
	120 Mountain View Boulevard
	Basking Ridge, NJ 07920
	
	Facsimile No.:
	Telephone No.: (908) 580-2100
	Attn: David Mazzo
	
	With a copy to:
	
	Lowenstein Sandler LLP
	1251 Avenue of the Americas
	New York, NY 10020
	Facsimile: (973) 597-2383
	Telephone: (973) 597-2382
	Attn: John Hogoboom, Esq.

 COMPANY SIGNATURE PAGE 

 Investor Signature Page 

By its execution and delivery of this signature page, the undersigned Investor hereby joins in and agrees to be bound by the terms and
conditions of the Securities Purchase Agreement dated as of January 31, 2014 (the “Purchase Agreement”) by and among Regado Biosciences, Inc. and the Investors (as defined therein), as to the number of shares of Common Stock set forth
below, and authorizes this signature page to be attached to the Purchase Agreement or counterparts thereof. 
  

			
	Name of Investor:
	
	  

		
	By:	 	  

		 	Name:
		 	Title:

  

			
	Address of Principal Executive Office:
	
	  

	
	  

		
	Telephone No.:	 	  

		
	Facsimile No.:	 	  

		
	Email Address:	 	  

		
	Number of Shares:	 	  

  

			
	Aggregate Purchase Price: $	 	  

 Exhibits: 
  

			
	A	  	Schedule of Investors
	B	  	Instruction Sheet for Investors
	C	  	Opinion of Company Corporate Counsel
	D	  	Plan of Distribution
	E	  	Company Transfer Agent Instructions
	F	  	Compliance Certificate
	G	  	Insider Certification

  
 -2- 

 Exhibit A 

Schedule of Investors 
  

							
	 Investor
	  	Common Shares	  	Purchase Price	 
		  		  			
		  		  			
		  		  			
	 TOTAL
	  		  	$	            	  

 Exhibit B 

INSTRUCTION SHEET FOR INVESTOR 

(to be read in conjunction with the entire Securities Purchase Agreement) 

 

	A.	Complete the following items in the Securities Purchase Agreement: 

  

	 	1.	Complete and execute the Investor Signature Page. The Agreement must be executed by an individual authorized to bind the Investor. 

  

	 	2.	Exhibit B-1 – Book-Entry Statement Questionnaire: 

 Provide the information requested
by the Book-Entry Statement Questionnaire. 
  

	 	3.	Exhibit B-2 - Registration Statement Questionnaire: 

 Provide the information requested by
the Registration Statement Questionnaire. 
  

	 	4.	Exhibit B-3 - Investor Certificate: 

 Provide the information requested by the Investor
Certificate. 
  

	 	5.	Return, via facsimile, the signed Securities Purchase Agreement including the properly completed Exhibits B-1 through B-3, to: 

Facsimile: 
 Telephone: 

Attn: 
  

	 	6.	After completing instruction number five (5) above, deliver the original signed Securities Purchase Agreement including the properly completed Exhibits B-1 through B-3 to: 

Facsimile: 
 Telephone: 

Attn: 
  

	B.	Instructions regarding the wire transfer of funds for the purchase of the Shares will be telecopied to the Investor by the Company at a later date. 

 Exhibit B-1 

REGADO BIOSCIENCES, INC. 

BOOK-ENTRY STATEMENT QUESTIONNAIRE 

Please provide us with the following information: 
  

					
	1.	 	The exact name that the Securities are to be registered in. You may use a nominee name if appropriate:	  	  

			
	2.	 	The relationship between the Investor of the Securities and the Registered Holder listed in response to item 1 above:	  	  

			
	3.	 	The mailing address, telephone and telecopy number and email address of the Registered Holder listed in response to item 1 above:	  	  

			
		 		  	  

			
		 		  	  

			
		 		  	  

			
		 		  	  

			
	4.	 	The Tax Identification Number of the Registered Holder listed in response to item 1 above:	  	  

 Exhibit B-2 

REGADO BIOSCIENCES, INC. 

REGISTRATION STATEMENT QUESTIONNAIRE 

In connection with the Registration Statement, please provide us with the following information regarding the Investor. 

1. Please state the Investor’s name exactly as it should appear in the Registration Statement: 

 

	
	  

 Except as set forth below, the Investor does not hold any equity securities of the Company on behalf of
another person or entity. 
 State any exceptions here: 
  

	
	  

 If the Investor is not a natural person, please identify the natural person or persons who will have voting and
investment control over the Registrable Securities owned by the Investor: 
  

	
	  

 2. Address of the Investor: 
  

	
	  

	
	  

  

					
	Telephone:	 	  
	 	
			
	Fax:	 	  
	 	
			
	Contact Person:	 	  
	 	

 3. Has the Investor had any position, office or other material relationship within the past three years with the Company or
its affiliates? (Include any relationships involving the Investor or its affiliates, officers, directors, or principal equity holders (5% or more) that has held any position or office or has had any other material relationship with the Company (or
its predecessors or affiliates) during the past three years.) 

                      
  Yes                    
                        No 

 If yes, please indicate the nature of any such relationship below: 

 

	
	  

 4. Except as set forth below in this Item 4, the Investor does not beneficially own (within the meaning of Rule 13d-3
under the Exchange Act) any securities of the Company. 
 (a) Number (and type) of Registrable Securities beneficially owned: 

 

	
	  

 (b) Number (and type) of securities of the Company other than Registrable Securities beneficially owned: 

 

	
	  

 (c) Number (and type) of Registrable Securities which the undersigned wishes to be included in the
Registration Statement: 
  

	
	  

 5. Except as set forth below in this Item 5, the Investor is not the beneficial or registered owner of any Registrable
Securities or any other securities of the Company, other than the securities listed above in Item 4. 
 State any exceptions here: 

 

	
	  

 6. Has the Investor made or is it aware of any arrangements relating to the distribution of the shares of the Company pursuant
to the Registration Statement? 

                      
  Yes                    
                        No 

If yes, please describe the nature and amount of such arrangements. 
  

	
	  

 7. FINRA Matters 

(a) State below whether the Investor is a member of FINRA. 
  

									
		 	Yes:	 		 	No:	 	
		 	
                     

	 		 	
                     

	 	

  
 -2- 

 (b) State below whether (i) any associate or affiliate of the Investor is a
member of FINRA, a controlling shareholder of a FINRA member, a person associated with a member, a direct or indirect affiliate of a member, or an underwriter or related person with respect to
the proposed offering; (ii) the Investor or any associate or affiliate of the Investor owns any stock or other securities of any FINRA member not purchased in the open market; or (iii) the Investor or any
associate or affiliate of the Investor has made any outstanding subordinated loans to any FINRA member. If the Investor is a general or limited partnership, a no answer asserts that no such relationship exists for the Investor
as well as for each of its general or limited partners. 
  

									
		 	Yes:	 		 	No:	 	
		 	
                     

	 		 	
                     

	 	

 If “yes,” please identify the FINRA member and describe the Investor’s relationship,
including, in the case of a general or limited partner, the name of the partner: 
  

	
	  

 (c) If the answer to Item 7 (b) is yes, did the Investor acquire the Registrable Securities in the
ordinary course of business (if not, please explain)? 
  

	
	  

 (d) If the answer to Item 7(b) is yes, did the Investor, at the time of purchase of the Registrable
Securities, have any agreements, plans or understandings, directly or indirectly, with any person to distribute the Registrable Securities (if yes, please explain)? 
  

	
	  

 If the Investor answered “no” to Question 7(a) and 7(b), it need not respond to Question 7(e). 

Note that in general we will be required to identify any registered broker-dealer as an underwriter in the Registration Statement. Note
that if the Investor is an associate or affiliate of a broker-dealer and did not purchase the Registrable Securities in the ordinary course of business or at the time of purchase had any arrangements or understandings, directly or indirectly, to
distribute the securities, the Investor may be required to be identified as an underwriter in the Registration Statement. 

(e) State below whether the Investor or any associate or affiliate of the Investor has been an underwriter, or a
controlling person or member of any investment banking or brokerage firm which has been or might be an underwriter for securities of the Corporation or any affiliate thereof including, but not limited to, the common stock now being
registered. 
  

									
		 	Yes:	 		 	No:	 	
		 	
                     

	 		 	
                     

	 	

  
 -3- 

 If “yes,” please identify the FINRA member and describe your relationship,
including, in the case of a general or limited partner, the name of the partner. 
  

	
	  

  
 -4- 

 ACKNOWLEDGEMENT 

The undersigned hereby agrees to notify the Company promptly of any changes in the foregoing information which should be made as a result of
any developments, including the passage of time. The undersigned also agrees to provide the Company and the Company’s counsel any and all such further information regarding the undersigned promptly upon request in connection with the
preparation, filing, amending, and supplementing of the Registration Statement (or any prospectus contained therein). The undersigned hereby consents to be named as a selling stockholder in the Registration Statement and to the use of all such
information in the Registration Statement. 
 The undersigned understands and acknowledges that the Company will rely on the information set
forth herein for purposes of the preparation and filing of the Registration Statement. 
 The undersigned understands that the undersigned
may be subject to serious civil and criminal liabilities if the Registration Statement, when it becomes effective, either contains an untrue statement of a material fact or omits to state a material fact required to be stated in the Registration
Statement or necessary to make the statements in the Registration Statement not misleading. The undersigned represents and warrants that all information it provides to the Company and its counsel is currently accurate and complete and will be
accurate and complete at the time the Registration Statement becomes effective and at all times subsequent thereto, and agrees during the Effectiveness Period and any additional period in which the undersigned is making sales of Shares under and
pursuant to the Registration Statement, and agrees during such periods to notify the Company immediately of any misstatement of a material fact in the Registration Statement, and of the omission of any material fact necessary to make the statements
contained therein not misleading. 
 Dated:
                     
  

	
	  

	Name
	
	  

	Signature
	
	  

	Name and Title of Signatory

  
 -5- 

 Exhibit B-3 

REGADO BIOSCIENCES, INC. 

CERTIFICATE FOR CORPORATE, PARTNERSHIP, LIMITED LIABILITY COMPANY,  

TRUST, FOUNDATION AND JOINT INVESTORS 

If the investor is a corporation, partnership, limited liability company, trust, pension plan, foundation, joint Investor (other than a
married couple) or other entity, an authorized officer, partner, or trustee must complete, date and sign this Certificate. 

CERTIFICATE 
 The
undersigned certifies that the representations and responses below are true and accurate: 
 (a) The investor has been duly formed and is
validly existing and has full power and authority to invest in the Company. The person signing on behalf of the undersigned has the authority to execute and deliver the Securities Purchase Agreement on behalf of the Investor and to take other
actions with respect thereto. 
 (b) Indicate the form of entity of the undersigned: 

            Limited Partnership 

            General Partnership 

            Limited Liability Company 

            Corporation 

            Revocable Trust (identify each grantor and indicate under what
circumstances the trust is revocable by the 

			
	grantor):	 	  

  
  

(Continue on a separate piece of paper, if necessary.) 

            Other type of Trust (indicate type of trust and, for trusts
other than pension trusts, name the grantors and 

			
	beneficiaries):	 	  

  
  

(Continue on a separate piece of paper, if necessary.) 
  

			
	
              Other form of organization (indicate form of 
organization (
	 	  

			
		
	  
	 	).

  

					
	 (c) Indicate the approximate date the undersigned entity was formed:
	 	  
	 	.

  
 -6- 

 (d) In order for the Company to offer and sell the Securities in conformance with state and
federal securities laws, the following information must be obtained regarding your investor status. Please initial each category applicable to you as an investor in the Company. 

 

	 	        	1. A bank as defined in Section 3(a)(2) of the Securities Act, or any savings and loan association or other institution as defined in Section 3(a)(5)(A) of the Securities Act whether acting in its individual or
fiduciary capacity; 

  

	 	        	2. A broker or dealer registered pursuant to Section 15 of the Securities Exchange Act of 1934; 

  

	 	        	3. An insurance company as defined in Section 2(13) of the Securities Act; 

  

	 	        	4. An investment company registered under the Investment Company Act of 1940 or a business development company as defined in Section 2(a)(48) of that Act; 

 

	 	        	5. A Small Business Investment Company licensed by the U.S. Small Business Administration under Section 301(c) or (d) of the Small Business Investment Act of 1958; 

 

	 	        	6. A plan established and maintained by a state, its political subdivisions, or any agency or instrumentality of a state or its political subdivisions, for the benefit of its employees, if such plan has total assets in
excess of $5,000,000; 

  

	 	        	7. An employee benefit plan within the meaning of the Employee Retirement Income Security Act of 1974, if the investment decision is made by a plan fiduciary, as defined in Section 3(21) of such Act, which is
either a bank, savings and loan association, insurance company, or registered investment advisor, or if the employee benefit plan has total assets in excess of $5,000,000 or, if a self-directed plan, with investment decisions made solely by persons
that are accredited investors; 

  

	 	        	8. A private business development company as defined in Section 202(a)(22) of the Investment Advisers Act of 1940; 

  

	 	        	9. Any partnership or corporation or any organization described in Section 501(c)(3) of the Internal Revenue Code or similar business trust, not formed for the specific purpose of acquiring the Shares, with total
assets in excess of $5,000,000; 

  

	 	        	10. A trust, with total assets in excess of $5,000,000, not formed for the specific purpose of acquiring the Shares, whose purchase is directed by a sophisticated person as described in Rule 506(b)(2)(ii) of
the Exchange Act; 

  

	 	        	11. An entity in which all of the equity owners qualify under any of the above subparagraphs. If the undersigned belongs to this investor category only, list the equity owners of the undersigned, and the investor
category which each such equity owner satisfies: 

  

	
	  

	(Continue on a separate piece of paper, if necessary.)

  
 -7- 

	 	(e)	As of the date hereof, please set forth below the dollar amount of securities in the aggregate in your portfolio or under management, including investments held by wholly owned subsidiaries. 

$         

(f) Please set forth in the space provided below the (i) states, if any, in the U.S. in which you maintained your principal office during
the past two years and the dates during which you maintained your office in each state, (ii) state(s), if any, in which you are incorporated or otherwise organized and (iii) state(s), if any, in which you pay income taxes. 

 

	
	  

	
	  

	
	  

  

	
	Dated:            , 200    
	
	  

	Print Name of Investor
	
	  

	Name:
	Title:
	(Signature and title of authorized officer, partner or trustee)
	

  
 -8- 

 Exhibit C 

OPINION OF COMPANY CORPORATE COUNSEL 

 Exhibit D 

PLAN OF DISTRIBUTION 
 The selling
stockholders may, from time to time, sell any or all of their shares of common stock on any stock exchange, market or trading facility on which the shares are traded or in private transactions. These sales may be at fixed or negotiated prices. The
selling stockholders may use any one or more of the following methods when selling shares: 
  

	•	 	ordinary brokerage transactions and transactions in which the broker-dealer solicits purchasers; 

  

	•	 	block trades in which the broker-dealer will attempt to sell the shares as agent but may position and resell a portion of the block as principal to facilitate the transaction; 

 

	•	 	purchases by a broker-dealer as principal and resale by the broker-dealer for its account; 

  

	•	 	an exchange distribution in accordance with the rules of the applicable exchange; 

  

	•	 	privately negotiated transactions; 

  

	•	 	short sales effected after the date the registration statement of which this Prospectus is a part is declared effective by the SEC; 

  

	•	 	broker-dealers may agree with the selling stockholders to sell a specified number of such shares at a stipulated price per share; 

  

	•	 	a combination of any such methods of sale; and 

  

	•	 	any other method permitted pursuant to applicable law. 

 The selling stockholders may also sell
shares under Rule 144 under the Securities Act, if available, rather than under this prospectus. 
 Broker-dealers engaged by the selling
stockholders may arrange for other brokers-dealers to participate in sales. Broker-dealers may receive commissions or discounts from the selling stockholders (or, if any broker-dealer acts as agent for the purchaser of shares, from the purchaser) in
amounts to be negotiated. The selling stockholders do not expect these commissions and discounts to exceed what is customary in the types of transactions involved. Any profits on the resale of shares of common stock by a broker-dealer acting as
principal might be deemed to be underwriting discounts or commissions under the Securities Act. Discounts, concessions, commissions and similar selling expenses, if any, attributable to the sale of shares will be borne by a selling stockholder. The
selling stockholders may agree to indemnify any agent, dealer or broker-dealer that participates in transactions involving sales of the shares if liabilities are imposed on that person under the Securities Act. 

The selling stockholders may from time to time pledge or grant a security interest in some or all of the shares of common stock owned by them
and, if they default in the performance of their secured obligations, the pledgees or secured parties may offer and sell the shares of common stock from time to time under this 

 
prospectus after we have filed a supplement to this prospectus under Rule 424(b)(3) or other applicable provision of the Securities Act of 1933 supplementing or amending the list of selling
stockholders to include the pledgee, transferee or other successors in interest as selling stockholders under this prospectus. 
 The
selling stockholders also may transfer the shares of common stock in other circumstances, in which case the transferees, pledgees or other successors in interest will be the selling beneficial owners for purposes of this prospectus and may sell the
shares of common stock from time to time under this prospectus after we have filed a supplement to this prospectus under Rule 424(b)(3) or other applicable provision of the Securities Act of 1933 supplementing or amending the list of selling
stockholders to include the pledgee, transferee or other successors in interest as selling stockholders under this prospectus. 
 The
selling stockholders and any broker-dealers or agents that are involved in selling the shares of common stock may be deemed to be “underwriters” within the meaning of the Securities Act in connection with such sales. In such event, any
commissions received by such broker-dealers or agents and any profit on the resale of the shares of common stock purchased by them may be deemed to be underwriting commissions or discounts under the Securities Act. 

We are required to pay all fees and expenses incident to the registration of the shares of common stock. We have agreed to indemnify the
selling stockholders against certain losses, claims, damages and liabilities, including liabilities under the Securities Act. 
 The selling
stockholders have advised us that they have not entered into any agreements, understandings or arrangements with any underwriters or broker-dealers regarding the sale of their shares of common stock, nor is there an underwriter or coordinating
broker acting in connection with a proposed sale of shares of common stock by any selling stockholder. If we are notified by any selling stockholder that any material arrangement has been entered into with a broker-dealer for the sale of shares of
common stock, if required, we will file a supplement to this prospectus. If the selling stockholders use this prospectus for any sale of the shares of common stock, they will be subject to the prospectus delivery requirements of the Securities Act.

 In order to comply with the securities laws of some states, if applicable, the common stock may be sold in these jurisdictions only
through registered or licensed brokers or dealers. In addition, in some states the common stock may not be sold unless it has been registered or qualified for sale or an exemption from registration or qualification requirements is available and is
complied with. 
 We have advised the selling stockholders that the anti-manipulation rules of Regulation M under the Exchange Act may apply
to sales of shares in the market and to the activities of the selling stockholders and their affiliates. In addition, to the extent applicable we will make copies of this prospectus (as it may be supplemented or amended from time to time) available
to the selling stockholders for the purpose of satisfying the prospectus delivery requirements of the Securities Act. The selling stockholders may indemnify any broker-dealer that participates in transactions involving the sale of the shares against
certain liabilities, including liabilities arising under the Securities Act. 
 We have agreed with the selling stockholders to keep the
registration statement of which this prospectus constitutes a part effective until the earliest of (1) such time as all of the shares covered by this prospectus have been disposed of pursuant to and in accordance with the registration
statement, (2) the date on which all of the shares may be sold without restriction pursuant to Rule 144 of the Securities Act and (3) two years from the date of this prospectus. 

  
 -2- 

 Exhibit E 

COMPANY TRANSFER AGENT INSTRUCTIONS 

American Stock Transfer & Trust Company, LLC 
 6201 15th Avenue 
 Brooklyn, NY 11219 

Attention: Leicia Savinetti 
 Ladies and Gentlemen: 

Reference is made to that certain Securities Purchase Agreement, dated as of January 31, 2014 (the “Agreement”), by and among Regado
Biosciences, Inc., a Delaware corporation (the “Company”), and the investors named on the Schedule of Investors attached thereto (collectively, the “Holders”), pursuant to which the Company is issuing to the Holders
shares (the “Common Shares”) of Common Stock of the Company, par value $0.001 per share (the “Common Stock”). 

This letter shall serve as our irrevocable authorization and direction to you (provided that you are the transfer agent of the Company at such
time and the conditions set forth in this letter are satisfied), subject to any stop transfer instructions that we may issue to you from time to time, if any to remove the legend from any Common Shares represented by a book-entry statement, to
transfer the Common Shares in book-entry form and to issue a new book-entry statement representing shares of Common Stock upon transfer or resale of the Common Shares. 

You acknowledge and agree that so long as you have previously received (a) written confirmation from the Company’s legal counsel
that either (i) a registration statement covering resales of the Common Shares (the “Registration Statement”) has been declared effective by the Securities and Exchange Commission (the “SEC”) under the
Securities Act of 1933, as amended (the “Securities Act”), and that resales of the Common Shares may be made thereunder in accordance with the Plan of Distribution set forth in the prospectus relating thereto (the
“Prospectus”), or (ii) sales of the Common Shares have been made in conformity with Rule 144 under the Securities Act (“Rule 144”), (b) if applicable, a copy of the Registration Statement, (c) if
applicable, an undertaking from the Holder (the “Undertaking”) that it (i) is the owner of Common Shares, (ii) is named as a Selling Stockholder in the Prospectus, (iii) will sell all such Common Shares pursuant to
the Registration Statement and in accordance with the Plan of Distribution set forth in the Prospectus related thereto, and (iv) if the Company advises it that Rule 172 is not applicable, will deliver a current Prospectus to the purchaser of
such Common Shares in connection with such sale and/or a copy of the Prospectus is on file with the SEC, (d) if applicable, a notice from a Holder, that a transfer of Common Shares owned by such Holder has been effected pursuant to Rule 144,
then, unless otherwise required by law, within three (3) business days of your receipt of the undertaking referred to in (c) or the notice referred to in (d), you shall issue a book-entry statement evidencing the Common Shares to the
Holder or to the transferees of the Holder, as applicable, registered in the name of such Holder or such transferees, which shall not bear any legend restricting transfer of such Common Shares and should not be subject to any stop-transfer
restriction. 
 A form of written confirmation (to be used in connection with any sale) from the Company’s outside legal counsel that a
registration statement covering resales of the Common Shares has been declared effective by the SEC under the Securities Act is attached hereto as Exhibit I. The form of Undertaking to be completed by a Holder pursuant to clause (c) of
the prior paragraph is attached as Annex A to such counsel confirmation. 

 Please be advised that the Holders are relying upon this letter as an inducement to enter into
the Agreement and, accordingly, each Holder is a third party beneficiary to these instructions. 
 Please execute this letter in the space
indicated to acknowledge your agreement to act in accordance with these instructions. Should you have any questions concerning this matter, please contact me at (908) 580-2100. 

  
 -2- 

 
			
	Very truly yours,
	
	REGADO BIOSCIENCES, INC.
		
	By:	 	  

		 	Name:
		 	Title:

  

					
	 THE FOREGOING INSTRUCTIONS ARE ACKNOWLEDGED AND AGREED TO

this      day of             , 20    

	
	American Stock Transfer & Trust Company, LLC
		
	By:	 	  

		 	Name:	 	  

		 	Title:	 	  

 Enclosures 

  
 -3- 

 EXHIBIT I 

FORM OF NOTICE OF EFFECTIVENESS 

OF REGISTRATION STATEMENT 
 American Stock
Transfer & Trust Company, LLC 
 6201 15th Avenue 

Brooklyn, NY 11219 
 Attention: 

 

			
	Re:	  	Regado Biosciences, Inc.

 Ladies and Gentlemen: 

We are counsel to Regado Biosciences, Inc., a Delaware corporation (the “Company”), and have represented the Company in
connection with that certain Securities Purchase Agreement, dated as of January 31, 2014 (the “Securities Purchase Agreement”), entered into by and among the Company and the buyers named therein (collectively, the
“Holders”) pursuant to which the Company issued to the Holders shares (the “Common Shares”) of the Company’s common stock, par value $0.001 per share (the “Common Stock”). Pursuant to the
Securities Purchase Agreement, the Company agreed, among other things, to register the Common Shares under the Securities Act of 1933, as amended (the “1933 Act”), for resale by the Holders. In connection with the Company’s
obligations under the Securities Purchase Agreement, on                  , 2014, the Company filed a Registration Statement on Form S-1 (File
No. 333-            ) (the “Registration Statement”) with the Securities and Exchange Commission (the “SEC”) relating to the Registrable Securities
which names each of the Holders as a selling stockholder thereunder. 
 In connection with the foregoing, we advise you that a member of the
SEC’s staff has advised us by telephone that the SEC has entered an order declaring the Registration Statement effective under the 1933 Act and we have no knowledge, after telephonic inquiry of a member of the SEC’s staff, that any stop
order suspending its effectiveness has been issued or that any proceedings for that purpose are pending before, or threatened by, the SEC and the Common Shares are available for resale under the 1933 Act pursuant to the Registration Statement. 

So long as neither we nor the Company have advised you that sales of the Common Shares under the Registration Statement have been suspended,
upon receipt by you of (i) a written request from a Holder to register a transfer of its Common Shares or a request to remove the restricted legend from the book-entry statement representing its Common Shares, and (ii) a completed
Undertaking in the form attached hereto as Annex A relating to such Common Shares, you may remove any stop order on your books relating to such Common Shares, remove the restricted legend on your books, effect the transfer requested
(if applicable) and issue a new book-entry statement representing such Common Shares in accordance with the transfer instructions or removal request, free of any restrictive legend or any stop order on your books relating to such Common Shares. 

 

	
	Very truly yours,
	
	LOWENSTEIN SANDLER, LLP

 CC: [LIST NAMES OF HOLDERS] 

 Annex A 

UNDERTAKING 
  

			
	To:	  	American Stock Transfer & Trust Company, LLC
		  	Regado Biosciences, Inc. and
		  	Lowenstein Sandler LLP

 The undersigned [an officer of, or other person duly authorized by]
                                 [fill in official name of individual or institution]
hereby certifies that he/she [said institution] (i) is the owner of                  shares (the “Common Shares”) of Common Stock, par value $0.001 per
share (the “Common Stock”), of Regado Biosciences, Inc.(the “Company”) evidenced by a book-entry statement on the books of the transfer agent for the Common Stock, and as such, (ii) is named as a “selling
stockholder” in the prospectus (the “Prospectus”) of the Company included in the Company’s registration Statement (File No. 333-—) (the “Registration Statement”),
(iii) will sell all of such Common Shares pursuant to the Company’s Registration Statement and in accordance with the Plan of Distribution set forth in the Prospectus related thereto and (iv) if the Company advises the undersigned
that Rule 172 is not applicable, will deliver a current Prospectus to the purchaser of such shares in connection with such sale and/or a copy of the Prospectus is on file with the Securities and Exchange Commission. The undersigned hereby further
certifies that he/she [said institution] will sell the Common Shares ONLY (1) under the Registration Statement at such time as the Registration Statement is effective and not during the pendency of a stop order or other suspension of
effectiveness of the Registration Statement, and in accordance with the Plan of Distribution contained in the Registration Statement or (2) pursuant to Rule 144 promulgated under the U.S. Securities Act of 1933, as amended. 

 

					
	Print or type:	 		 	
	Name of Selling Stockholder (Individual or Institution):	 	  
	 	
			
	 Name of Individual Representing

Selling Stockholder

(if an Institution):
	 	  
	 	
			
	 Title of Individual Representing

Selling Stockholder

(if an Institution):
	 	  
	 	
			
	Signature by:	 		 	
			
	Individual Selling Stockholder or Individual representing Selling Stockholder:	 	  
	 	

  

							
	Dated:	 	  

  
 -2- 

 EXHIBIT F 

FORM OF OFFICER’S CERTIFICATE 

February 5, 2014 
 The
undersigned, the President and Chief Executive Officer of Regado Biosciences, Inc., a Delaware corporation (the “Company”), pursuant to Section 5.1(i) of the Securities Purchase Agreement, dated as of January 31,
2014 by and among the Company and the investors signatory thereto (the “Securities Purchase Agreement”), hereby represents, warrants and certifies as follows (capitalized terms used but not otherwise defined herein shall have the
meaning set forth in the Securities Purchase Agreement): 
  

	 	1.	The representations and warranties of the Company contained in the Securities Purchase Agreement are true and correct in all material respects (except for those representations and warranties which are qualified as to
materiality, in which case, such representations and warranties are true and correct in all respects) as of the date when made and as of the date hereof, as though made on and as of such date, except for such representations and warranties that
speak as of a specific date, which were true and correct in all material respects as of such earlier date (except those (except for those representations and warranties which are qualified as to materiality, in which case, such representations and
warranties were true and correct in all respects as of such specified date). 

  

	 	2.	The Company has performed, satisfied and complied in all material respects with all covenants, agreements and conditions required by the Transaction Documents to be performed, satisfied or complied with by it at or
prior to the date hereof. 

 [Signature Page Follows] 

 Exhibit G 

INSIDER CERTIFICATION 

  
 -2-

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