Document:

Exhibit
4.1

    NEOPROBE
CORPORATION

    

    CERTIFICATE
OF DESIGNATIONS, VOTING POWERS,

    PREFERENCES,
LIMITATIONS, RESTRICTIONS, AND RELATIVE

    RIGHTS
OF SERIES B CONVERTIBLE PREFERRED STOCK

     

    It is
hereby certified that:

    

    I.           The
name of the corporation is Neoprobe Corporation (the “Corporation”), a
Delaware corporation.

    

    II.           Set
forth hereinafter is a statement of the voting powers, preferences, limitations,
restrictions, and relative rights of shares of Series B Convertible Preferred
Stock hereinafter designated as contained in a resolution of the Board of
Directors of the Corporation pursuant to a provision of the Certificate of
Incorporation of the Corporation permitting the issuance of said Series B
Preferred Stock by resolution of the Board of Directors:

    

    1.           Designation and
Rank.

     

    (a)           Designation.  The
designation of such series of the Preferred Stock shall be the Series B
Convertible Preferred Stock, par value $.001 per share (the “Series B Preferred
Stock”).  The maximum number of shares of Series B Preferred
Stock shall be Ten Thousand (10,000) Shares.

     

    (b)           Rank.  The
Series B Preferred Stock shall rank prior to the common stock, par value $.001
per share (the “Common
Stock”), and to all other classes and series of equity securities of the
Company which by their terms do not rank on a parity with or senior to the
Series B Preferred Stock (“Junior
Stock”).   The Series C Convertible Preferred Stock shall
rank senior to the Series B Preferred Stock as to rights to cash dividends, and
on a parity with the Series B Preferred Stock as to distributions on
liquidation, dissolution or winding up. The Series B Preferred Stock shall be
subordinate to and rank junior to all indebtedness of the Company now or
hereafter outstanding.

     

    2.           Dividends. Whenever
the Board of Directors declares a dividend on the Common Stock each holder of
record of a share of Series B Preferred Stock, or any fraction of a share of
Series B Preferred Stock, on the date set by the Board of Directors to determine
the owners of the Common Stock of record entitled to receive such dividend (the
“Record Date”)
shall be entitled to receive, out of any assets at the time legally available
therefore, an amount equal to such dividend declared on one share of Common
Stock multiplied by the number of shares of Common Stock into which such share,
or such fraction of a share, of Series B Preferred Stock could be converted on
the Record Date, without regard to Section 7 hereof.

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    3.           Voting
Rights.

     

    (a)           Class Voting
Rights.  The Series B Preferred Stock shall have the following
class voting rights.  The Company shall not, without the affirmative
vote or consent of the holders of at least a majority of the shares of the
Series B Preferred Stock outstanding at the time, given in person or by proxy,
either in writing or at a meeting, in which the holders of the Series B
Preferred Stock vote separately as a class, amend, alter or repeal the
provisions of the Series B Preferred Stock so as to adversely affect any right,
preference, privilege or voting power of the Series B Preferred Stock. So long
as at least 25% of the shares of the Series B Preferred Stock remain
outstanding, the Company shall not, without the affirmative vote or consent of
the holders of at least a majority of the shares of the Series B Preferred Stock
outstanding at the time, given in person or by proxy, either in writing or at a
meeting, in which the holders of the Series B Preferred Stock vote separately as
a class: (i) repurchase, redeem or pay dividends on (whether in cash, in kind,
or otherwise), shares of the Company's Junior Stock; (ii) at any time prior to
December 31, 2011, issue or permit to exist any indebtedness for borrowed money,
except for (x) obligations under conditional sale or other title retention
agreements relating to capital assets acquired by the Company, (y) borrowings
from a bank or other financial institution under a working capital line or
revolving line of credit in an aggregate principal amount of less than
$2,000,000, or (z) indebtedness of the Subsidiaries (as such term is defined in
the Securities Purchase Agreement, dated as of December 26, 2007 between the
Company and Platinum-Montaur Life Sciences, LLC) of the Company in an aggregate
principal amount not to exceed $1,000,000; (iii) effect any distribution with
respect to any Junior Stock, or (iv) issue any Common Stock or
Common Stock equivalent for a per Common Stock share effective price less than
$1.35, other than (i) issuances of securities upon the exercise or exchange of
or conversion of any securities exercisable or exchangeable for or convertible
into shares of Common Stock issued and outstanding on the Issuance Date,
provided that such securities have not been amended since the Issuance Date to
increase the number of such securities or to decrease the exercise, exchange or
conversion price of any such securities; (ii) securities issued pursuant to
acquisitions or strategic transactions approved by a majority of the
disinterested directors, but not including a transaction with an entity whose
primary business is investing in securities or a transaction, the primary
purpose of which is to raise capital; or (iii) issuances, pursuant to employee
stock option plans approved by the Company's shareholders, of options to
employees, officers or directors of the Company, approved by a majority of the
non-employee members of the Board of Directors of the Company or a majority of
the members of a committee of nonemployee directors established for such
purpose. For purposes of clause (iv) above, the “per Common Stock share
effective price” in the case of any Common Stock equivalent shall be determined
by dividing (X) the total amount received or receivable by the Company as
consideration for the issue or sale of such Common Stock equivalents, plus the
minimum aggregate amount of additional consideration, if any, payable to the
Company upon the conversion or exercise thereof, by (B) the total maximum number
of shares of Common Stock issuable upon the conversion or exercise of all such
Common Stock equivalents.

     

    (b)           General Voting
Rights.  Except with respect to transactions upon which the
Series B Preferred Stock shall be entitled to vote separately as a class
pursuant to Section 3(a) above, the Series B Preferred Stock shall have no
voting rights.  The Common Stock into which the Series B Preferred
Stock is convertible shall, upon issuance, have all of the same voting rights as
other issued and outstanding Common Stock of the Company.

     

    4.           Liquidation
Preference.

     

    (a)           In
the event of the liquidation, dissolution or winding up of the affairs of the
Company, whether voluntary or involuntary, after payment or provision for
payment of the debts and other liabilities of the Company, the holders of shares
of the Series B Preferred Stock then outstanding shall be entitled to receive,
out of the assets of the Company, whether such assets are capital or surplus of
any nature, before any payment shall be made or any assets distributed to the
holders of the Common Stock or any other Junior Stock (but pari passu with any payment
to holders of Series C Convertible Preferred Stock), an amount per share of
Series B Preferred Stock calculated by taking the total amount available for
distribution to holders of all the Company’s outstanding Common Stock before
deduction of any preference payments for the Series B Preferred Stock or Series
C Convertible Preferred Stock, divided by the total of (x) all of the then
outstanding shares of the Company’s Common Stock, plus (y) all of the shares of
the Company’s Common Stock into which all of the outstanding shares of the
Series B Preferred Stock and Series C Convertible Preferred Stock can be
converted, and then (z) multiplying the sum so obtained by the number of shares
of Common Stock into which such share of Series B Preferred Stock could then be
converted (the “Liquidation Preference
Amount”).  The liquidation payment with respect to each
outstanding fractional share of Series B Preferred Stock shall be equal to a
ratably proportionate amount of the liquidation payment with respect to each
outstanding share of Series B Preferred Stock.  All payments for which
this Section 4(a) provides shall be in cash, property (valued at its fair market
value as determined by an independent appraiser reasonably acceptable to the
holders of a majority of the Series B Preferred Stock), or a combination
thereof; provided, however, that no cash shall be paid to holders of Junior
Stock unless each holder of the outstanding shares of Series B Preferred Stock
has been paid in cash the full Liquidation Preference Amount to which such
holder is entitled as provided herein.  After payment of the full
Liquidation Preference Amount to which each holder is entitled, such holders of
shares of Series B Preferred Stock will not be entitled to any further
participation as such in any distribution of the assets of the
Company.

     

    
      
         

      

      
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    (b)           A
consolidation or merger of the Company with or into any other corporation or
corporations, or a sale of all or substantially all of the assets of the
Company, or the effectuation by the Company of a transaction or series of
transactions in which more than 50% of the voting shares of the Company is
disposed of or conveyed, shall be, at the election of the holders of a majority
of the Series B Preferred Stock, deemed to be a liquidation, dissolution, or
winding up within the meaning of this Section 4; provided, however, that any
such transaction shall not be deemed to be a liquidation, dissolution or winding
up unless such transaction is approved by the Board of Directors of the Company
and the holders of the Series B Preferred Stock do not control the Board of
Directors.  In the event of the merger or consolidation of the Company
with or into another corporation that is not treated as a liquidation pursuant
to this Section 4(b), the Series B Preferred Stock shall maintain its relative
powers, designations and preferences provided for herein (including any
adjustment required under Section 5(c)(v) hereof) and no merger shall result
inconsistent therewith.

     

    (c)           Written
notice of any voluntary or involuntary liquidation, dissolution or winding up of
the affairs of the Company, stating a payment date and the place where the
distributable amounts shall be payable, shall be given by mail, postage prepaid,
no less than forty-five (45) days prior to the payment date stated therein, to
the holders of record of the Series B Preferred Stock at their respective
addresses as the same shall appear on the books of the Company.

     

    5.           Conversion.  The
holders of Series B Preferred Stock shall have the following conversion rights
(the “Conversion
Rights”):

     

    (a)           Right to
Convert.  At any time on or after the date of issuance of the
Series B Preferred Stock (the “Issuance Date”), the
holder of any such shares of Series B Preferred Stock may, at such holder’s
option, subject to the limitations set forth in Section 7 herein, elect to
convert (a “Voluntary
Conversion”) all or any portion of the shares of Series B Preferred Stock
held by such person into a number of fully paid and nonassessable shares of
Common Stock at a
conversion rate of Three Thousand Two Hundred Seventy (3,270) shares of Common
Stock for each share of Preferred Stock (subject to adjustments set forth in
Section 5(c) herein, the “Conversion
Rate”).  The Company shall keep written records of the
conversion of the shares of Series B Preferred Stock converted by each
holder.  A holder shall be required to deliver the original
certificates representing the shares of Series B Preferred Stock upon any
conversion of the Series B Preferred Stock as provided in Section 5(b)
below.

     

    (b)           Mechanics of Voluntary
Conversion.  The Voluntary Conversion of Series B Preferred
Stock shall be conducted in the following manner:

     

    
      
         

      

      
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    (i)              Holder's Delivery
Requirements.  To convert Series B Preferred Stock into full
shares of Common Stock on any date (the “Voluntary Conversion
Date”), the holder thereof shall (A) transmit by facsimile (or otherwise
deliver), for receipt on or prior to 5:00 p.m., Eastern Time on such date, a
copy of a fully executed notice of conversion in the form attached hereto
as  Exhibit I  (the “Conversion Notice”),
to the Company, and (B) with respect to the final conversion of shares of Series
B Preferred Stock held by any holder, such holder shall surrender to a common
carrier for delivery to the Company as soon as practicable following such
Conversion Date but in no event later than six (6) business days after such date
the original certificates representing the shares of Series B Preferred Stock
being converted (or an indemnification undertaking with respect to such shares
in the case of their loss, theft or destruction) (the “Preferred Stock
Certificates”).

     

    (ii)             Company's
Response.  Upon receipt by the Company of a facsimile copy of a
Conversion Notice, the Company shall immediately send, via facsimile, a
confirmation of receipt of such Conversion Notice to such holder and the Company
or its designated transfer agent (the “Transfer Agent”), as
applicable, shall, within five (5) business days following the date of receipt
by the Company of the certificate representing the shares of Series B Preferred
Stock being converted, (x) issue and deliver to the Depository Trust Company
(“DTC”) account
on the holder’s behalf via the Deposit Withdrawal Agent Commission System
(“DWAC”) as
specified in the Conversion Notice, registered in the name of the holder or its
designee, for the number of shares of Common Stock to which the holder shall be
entitled, and (y) if the certificate so surrendered represents more shares of
Series B Preferred Stock than those being converted, issue and deliver to the
holder a new certificate for such number of shares of Series B Preferred Stock
represented by the surrendered certificate which were not
converted.

     

    (iii)           
Record
Holder.  The person or persons entitled to receive the shares
of Common Stock issuable upon a conversion of the Series B Preferred Stock shall
be treated for all purposes as the record holder or holders of such shares of
Common Stock on the Conversion Date.

     

    (iv)            Company's Failure to Timely
Convert.  If within five (5) business days of the Company's
receipt of the Conversion Notice (the “Share Delivery
Period”) the Company shall fail to issue and deliver to a holder the
number of shares of Common Stock to which such holder is entitled upon such
holder's conversion of the Series B Preferred Stock (a “Conversion Failure”),
in addition to all other available remedies which such holder may pursue
hereunder, the Company shall pay additional damages to such holder on each
business day after such fifth (5th) business day that such conversion is not
timely effected in an amount equal to 0.5% of the product of (A) the sum of the
number of shares of Common Stock not so issued to the holder on a timely basis
pursuant to Section 5(b)(ii) and to which such holder is entitled and (B) the
closing bid price of the Common Stock on the last possible date which the
Company could have issued such Common Stock to such holder without violating
Section 5(b)(ii).  If the Company fails to pay the additional damages
set forth in this Section 5(b)(iv) within five (5) business days of the date
incurred, then such payment shall bear interest at the rate of 2% per month (pro
rated for partial months) until such payments are made.

     

    (c)      Adjustments of Conversion
Rate.

     

    (i)   Adjustments for Stock Splits and
Combinations.  If the Company shall at any time or from time to
time after the Issuance Date, effect a stock split of the outstanding Common
Stock, the Conversion Rate shall be proportionately increased.  If the
Company shall at any time or from time to time after the Issuance Date, combine
the outstanding shares of Common Stock, the Conversion Rate shall be
proportionately decreased.  Any adjustments under this Section 5(e)(i)
shall be effective at the close of business on the date the stock split or
combination occurs.

     

    
      
         

      

      
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    (ii)  Adjustments for Certain Dividends
and Distributions.  If the Company shall at any time or from
time to time after the Issuance Date, make or issue or set a record date for the
determination of holders of Common Stock entitled to receive a dividend or other
distribution payable in shares of Common Stock, then, and in each event, the
Conversion Rate shall be increased as of the time of such issuance or, in the
event such record date shall have been fixed, as of the close of business on
such record date, by multiplying, as applicable, the Conversion Rate then in
effect by a fraction:

     

    (A)     the
numerator of which shall be the total number of shares of Common Stock issued
and outstanding immediately following the time of such issuance or the close of
business on such record date; and

     

    (B)      the
denominator of which shall be the total number of shares of Common Stock issued
and outstanding immediately prior to the time of such issuance.

     

    (iii)   Adjustment for Other Dividends and
Distributions.  If the Company shall at any time or from time
to time after the Issuance Date, make or issue or set a record date for the
determination of holders of Common Stock entitled to receive a dividend or other
distribution payable in securities of the Company other than shares of Common
Stock, then, and in each event, an appropriate revision to the applicable
Conversion Rate shall be made and provision shall be made (by adjustments of the
Conversion Rate or otherwise) so that the holders of Series B Preferred Stock
shall receive upon conversions thereof, in addition to the number of shares of
Common Stock receivable thereon, the number of securities of the Company which
they would have received had their Series B Preferred Stock been converted into
Common Stock on the date of such event (without regard to Section 7 hereof) and
had thereafter, during the period from the date of such event to and including
the Conversion Date, retained such securities (together with any distributions
payable thereon during such period), giving application to all adjustments
called for during such period under this Section 5(c)(iii) with respect to the
rights of the holders of the Series B Preferred Stock.

     

    (iv)   Adjustments for Reclassification,
Exchange or Substitution.  If the Common Stock issuable upon
conversion of the Series B Preferred Stock at any time or from time to time
after the Issuance Date shall be changed to the same or different number of
shares of any class or classes of stock, whether by reclassification, exchange,
substitution or otherwise (other than by way of a stock split or combination of
shares or stock dividends provided for in Sections 5(c)(i), (ii) and (iii), or a
reorganization, merger, consolidation, or sale of assets provided for in Section
5(c)(v)), then, and in each event, an appropriate revision to the Conversion
Rate shall be made and provisions shall be made so that the holder of each share
of Series B Preferred Stock shall have the right thereafter to convert such
share of Series B Preferred Stock into the kind and amount of shares of stock
and other securities receivable upon reclassification, exchange, substitution or
other change, by holders of the number of shares of Common Stock into which such
share of Series B Preferred Stock might have been converted immediately prior to
such reclassification, exchange, substitution or other change (without giving
effect to the limitations set forth in Section 7 hereof), all subject to further
adjustment as provided herein.

     

    (v)    Adjustments for Reorganization,
Merger, Consolidation or Sales of Assets.  If at any time or
from time to time after the Issuance Date there shall be a capital
reorganization of the Company (other than by way of a stock split or combination
of shares or stock dividends or distributions provided for in Section 5(c)(i),
(ii) and (iii), or a reclassification, exchange or substitution of shares
provided for in Section 5(c)(iv)), or a merger or consolidation of the Company
with or into another corporation, or the sale of all or substantially all of the
Company's properties or assets to any other person that is not deemed a
liquidation pursuant to Section 4(b) (an “Organic Change”),
then as a part of such Organic Change an appropriate revision to the Conversion
Rate  shall be made and provision shall be made so that the holder of
each share of Series B Preferred Stock shall have the right thereafter to
convert such share of Series B Preferred Stock into the kind and amount of
shares of stock and other securities or property of the Company or any successor
corporation resulting from the Organic Change as the holder would have received
as a result of the Organic Change and if the holder had converted its Series B
Preferred Stock (without regard to Section 7 hereof) into the Company’s Common
Stock prior to the Organic Change.

     

    
      
         

      

      
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    (vi)   Record Date.  In
case the Company shall take record of the holders of its Common Stock or any
other Preferred Stock for the purpose of entitling them to subscribe for or
purchase Common Stock or Convertible Securities, then the date of the issue or
sale of the shares of Common Stock shall be deemed to be such record
date.

     

    (d)           No
Impairment.  The Company shall not, by amendment of its
Certificate of Incorporation or through any reorganization, transfer of assets,
consolidation, merger, dissolution, issue or sale of securities or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the terms to be observed or performed hereunder by the Company, but will at all
times in good faith, assist in the carrying out of all the provisions of this
Section 5 and in the taking of all such action as may be necessary or
appropriate in order to protect the Conversion Rights of the holders of the
Series B Preferred Stock against impairment. In the event a holder shall elect
to convert any shares of Series B Preferred Stock as provided herein, the
Company cannot refuse conversion based on any claim that such holder or anyone
associated or affiliated with such holder has been engaged in any violation of
law, unless an injunction from a court, on notice, restraining and/or adjoining
conversion of all or of said shares of Series B Preferred Stock shall have been
issued.

     

    (e)           Certificates as to
Adjustments.  Upon occurrence of each adjustment or
readjustment of the Conversion Rate or number of shares of Common Stock issuable
upon conversion of the Series B Preferred Stock pursuant to this Section 5, the
Company at its expense shall promptly compute such adjustment or readjustment in
accordance with the terms hereof and furnish to each holder of such Series B
Preferred Stock a certificate setting forth such adjustment and readjustment,
showing in detail the facts upon which such adjustment or readjustment is
based.  The Company shall, upon written request of the holder of such
affected Series B Preferred Stock, at any time, furnish or cause to be furnished
to such holder a like certificate setting forth such adjustments and
readjustments, the Conversion Rate in effect at the time, and the number of
shares of Common Stock and the amount, if any, of other securities or property
which at the time would be received upon the conversion of a share of such
Series B Preferred Stock.  Notwithstanding the foregoing, the Company
shall not be obligated to deliver a certificate unless such certificate would
reflect an increase or decrease of at least one percent (1%) of such adjusted
amount.

     

    (f)           Issue
Taxes.  The Company shall pay any and all issue and other
taxes, excluding federal, state or local income taxes, that may be payable in
respect of any issue or delivery of shares of Common Stock on conversion of
shares of Series B Preferred Stock pursuant thereto;  provided,  however,
that the Company shall not be obligated to pay any transfer taxes resulting from
any transfer requested by any holder in connection with any such
conversion.

     

    
      
         

      

      
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    (g)           Notices.  Any
notice, demand, request, waiver or other communication required or permitted to
be given hereunder shall be in writing and shall be effective (i) upon hand
delivery, telecopy or facsimile at the address or number designated in the
Exchange Agreement (if delivered on a business day during normal business hours
where such notice is to be received), or the first business day following such
delivery (if delivered other than on a business day during normal business hours
where such notice is to be received) or (ii) on the second business day
following the date of mailing by express overnight courier service, fully
prepaid, addressed to such address, or upon actual receipt of such mailing,
whichever shall first occur. The Company will give written notice each holder of
Series B Preferred Stock at least ten (10) days prior to the date on which the
Company takes a record (A) with respect to any dividend or distribution upon the
Common Stock, (B) with respect to any pro rata subscription offer to holders of
Common Stock or (C) for determining rights to vote with respect to any Organic
Change, dissolution, liquidation or winding-up and in no event shall such notice
be provided to such holder prior to such information being made known to the
public. Subject to Section 4(c), the Company will also give written notice to
each holder of Series B Preferred Stock at least ten (10) days prior to the date
on which any Organic Change will take place and in no event shall such notice be
provided to such holder  prior to such information being made known to
the public

     

    (h)           Fractional
Shares.  No fractional shares of Common Stock shall be issued
upon conversion of the Series B Preferred Stock.  In lieu of any
fractional shares to which the holder would otherwise be entitled, the Company
shall at its option either (i) pay cash equal to the product of such fraction
multiplied by the average of the closing bid prices of the Common Stock for the
five (5) consecutive trading days immediately preceding the Voluntary Conversion
Date, as applicable, or (ii) in lieu of issuing such fractional shares issue one
additional whole share to the holder.

     

    (i)           Reservation of Common
Stock.  The Company shall, so long as any shares of Series B
Preferred Stock are outstanding, reserve and keep available out of its
authorized and unissued Common Stock, solely for the purpose of effecting the
conversion of the Series B Preferred Stock, such number of shares of Common
Stock as shall from time to time be sufficient to effect the conversion of all
of the Series B Preferred Stock then outstanding (without regard to the
limitations on conversion set forth in Section 7 hereof).

     

    (j)           Retirement of Series B
Preferred Stock.  Conversion of Series B Preferred Stock shall
be deemed to have been effected on the applicable Voluntary Conversion
Date.  The Company shall keep written records of the conversion of the
shares of Series B Preferred Stock converted by each holder.  A holder
shall be required to deliver the original certificates representing the shares
of Series B Preferred Stock upon complete conversion of the Series B Preferred
Stock represented by such certificates. A delivery of original certificates
pursuant to Section 5(b)(i) shall be deemed to comply with the requirements of
this Section 5(j).

     

    (k)           Regulatory
Compliance.  If any shares of Common Stock to be reserved for
the purpose of conversion of Series B Preferred Stock require registration or
listing with or approval of any governmental authority, stock exchange or other
regulatory body under any federal or state law or regulation or otherwise before
such shares may be validly issued or delivered upon conversion, the Company
shall, at its sole cost and expense, in good faith and as expeditiously as
possible, endeavor to secure such registration, listing or approval, as the case
may be.

     

    6.           No Preemptive
Rights.  Except as provided in Section 5 hereof, no holder of
the Series B Preferred Stock shall be entitled to rights to subscribe for,
purchase or receive any part of any new or additional shares of any class,
whether now or hereinafter authorized, or of bonds or debentures, or other
evidences of indebtedness convertible into or exchangeable for shares of any
class, but all such new or additional shares of any class, or any bond,
debentures or other evidences of indebtedness convertible into or exchangeable
for shares, may be issued and disposed of by the Board of Directors on such
terms and for such consideration (to the extent permitted by law), and to such
person or persons as the Board of Directors in their absolute discretion may
deem advisable.

     

    
      
         

      

      
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    7.           Conversion
Restriction.  Notwithstanding anything to the contrary set
forth in Section 5 of this Certificate of Designation, at no time may a holder
of shares of Series B Preferred Stock convert shares of the Series B Preferred
Stock if the number of shares of Common Stock to be issued pursuant to such
conversion would exceed, when aggregated with all other shares of Common Stock
owned by such holder at such time, the number of shares of Common Stock which
would result in such holder owning (as determined in accordance with Section
13(d) of the Securities Exchange Act of 1934, as amended, and the rules
thereunder) more than 9.99% of all of the Common Stock outstanding at such
time;  provided,  however,
that upon a holder of Series B Preferred Stock  providing the Company
with sixty-one (61) days notice (pursuant to Section 5(g) hereof) (the “Waiver Notice”) that
such holder would like to waive Section 7 of this Certificate of Designation
with regard to any or all shares of Common Stock issuable upon conversion of
Series B Preferred Stock, this Section 7 shall be of no force or effect with
regard to those shares of Series B Preferred Stock referenced in the Waiver
Notice.

     

    8.           Inability to Fully
Convert.

     

    (a)           Holder's Option if Company
Cannot Fully Convert.  If, upon the Company's receipt of a
Conversion Notice, the Company cannot issue shares of Common Stock for any
reason, including, without limitation, because the Company (i) does not have a
sufficient number of shares of Common Stock authorized and available, or (ii) is
otherwise prohibited by applicable law or by the rules or regulations of any
stock exchange, interdealer quotation system or other self-regulatory
organization with jurisdiction over the Company or its securities from issuing
all of the Common Stock which is to be issued to a holder of Series B Preferred
Stock pursuant to a Conversion Notice, then the Company shall issue as many
shares of Common Stock as it is able to issue in accordance with such holder's
Conversion Notice, and with respect to the unconverted Series B Preferred Stock
(the “Unconverted
Preferred Stock”), the holder, solely at such holder's option, can elect
to, at any time after receipt of notice from the Company that there is
Unconverted Preferred Stock, to void the holder’s Conversion Notice as to the
number of shares of Common Stock the Company is unable to issue and retain or
have returned, as the case may be, the certificates for the shares of the
Unconverted Preferred Stock.

     

    (b)           Mechanics of Fulfilling
Holder's Election.  The Company shall immediately send via
facsimile to a holder of Series B Preferred Stock, upon receipt of a facsimile
copy of a Conversion Notice from such holder which cannot be fully satisfied as
described in Section 8(a) above, a notice of the Company's inability to fully
satisfy such holder's Conversion Notice (the “Inability to Fully Convert
Notice”).  Such Inability to Fully Convert Notice shall
indicate (i) the reason why the Company is unable to fully satisfy such holder's
Conversion Notice, and (ii) the number of shares of Series B Preferred Stock
which cannot be converted.

     

    9.           Automatic
Conversion.

     

    (a)           Automatic Conversion
Events.  All outstanding shares of Series B Preferred Stock
shall be automatically converted into Common Stock at the Conversion Rate upon
the earlier to occur of (i) the closing of a firm commitment underwritten public
offering of Common Stock of the Company pursuant to an effective registration
statement under Section 5 of the Securities Act  in which the gross
cash proceeds to the Company (before underwriting discounts, commissions and
fees) from such public offering are at least $10,000,000, or (ii) December 31,
2012 (each, an “Automatic Conversion
Event”).

     

    
      
         

      

      
        8

        
          

        

      

      
         

      

    

    (b)           Mechanics of Automatic
Conversion.  Upon the occurrence of an Automatic Conversion
Event, the outstanding Series B Preferred Stock shall be converted into Common
Stock automatically without any further action by the holders of such shares and
whether or not the certificates representing such shares are surrendered to the
Company or its transfer agent; provided, however, that the
Company shall not be obligated to issue certificates evidencing the Common Stock
issuable upon such conversion unless the certificates evidencing such Series B
Preferred Stock are either delivered to the Company or its transfer agent as
provided below, or the holder certifies to the Company or its transfer agent
that such certificates have been lost, stolen or destroyed and executes an
agreement satisfactory to the Company to indemnify the Company from any loss
incurred by it in connection with such certificates. Upon surrender by any
holder of the certificates formerly representing shares of Series B Preferred
Stock to the Company or the transfer agent, there shall be issued and delivered
to such holder promptly in its name as shown on such surrendered certificate or
certificates, a certificate or certificates for the number of shares of Common
Stock into which the shares of Series B Preferred Stock surrendered were
converted on the date on which such automatic conversion occurred, and the
Company shall promptly pay in cash (at the fair market value per share of Common
Stock determined by the Board of Directors as of the date of conversion) the
value of any fractional share of Common Stock otherwise issuable to any holder
of shares of Series B Preferred Stock being converted. Until surrendered as
provided above, each certificate formerly representing Series B Preferred Stock
shall be deemed for all corporate purposes to represent the number of shares of
Common Stock resulting from such automatic conversion.

     

    (c)           Inability to
Convert.  Notwithstanding the provisions of Section 9(a) if,
upon the occurrence of an Automatic Conversion Event, the Company cannot issue
shares of Common Stock to fully effect the conversion for any reason, including,
without limitation, because the Company (i) does not have a sufficient number of
shares of Common Stock authorized and available, (ii) is otherwise prohibited by
applicable law or by the rules or regulations of any stock exchange, interdealer
quotation system or other self-regulatory organization with jurisdiction over
the Company or its securities from issuing all of the Common Stock which is to
be issued to a holder of Series B Preferred Stock, or (iii) the conversion would
be prohibited by the provisions of Section 7 hereof and such prohibition has not
been waived by the holder, then the Company shall issue as many shares of Common
Stock as it is able to issue, and with respect to the unconverted Series B
Preferred Stock (the “Unconverted Preferred
Stock”), deliver to the holder a certificate for the shares of the
Unconverted Preferred Stock.  In the event that the Company is
thereafter able to convert the Unconverted Preferred Stock, it shall so notify
the holder in writing, and such notice shall be deemed to be an Automatic
Conversion Event for purposes of this Section 9.

     

    10.           Vote to Change the Terms of
Preferred Stock.  The affirmative vote at a meeting duly called
for such purpose, or the written consent without a meeting, of the holders of
not less than a majority of the then outstanding shares of Series B Preferred
Stock, shall be required for any change to this Certificate of Designation or
the Company’s Certificate of Incorporation that would amend, alter, change or
repeal any of the powers, designations, preferences and rights of the Series B
Preferred Stock.

     

    11.           Lost or Stolen
Certificates.  Upon receipt by the Company of evidence
satisfactory to the Company of the loss, theft, destruction or mutilation of any
certificates representing the shares of Series B Preferred Stock, and, in the
case of loss, theft or destruction, of any indemnification undertaking by the
holder to the Company and, in the case of mutilation, upon surrender and
cancellation of such certificate(s), the Company shall execute and deliver new
preferred stock certificate(s) of like tenor and date.

     

    12.           Remedies, Characterizations,
Other Obligations, Breaches and Injunctive Relief.  The
remedies provided in this Certificate of Designation shall be cumulative and in
addition to all other remedies available under this Certificate of Designation,
at law or in equity (including a decree of specific performance and/or other
injunctive relief), no remedy contained herein shall be deemed a waiver of
compliance with the provisions giving rise to such remedy and nothing herein
shall limit a holder's right to pursue actual damages for any failure by the
Company to comply with the terms of this Certificate of
Designation.  Amounts set forth or provided for herein with respect to
payments, conversion and the like (and the computation thereof) shall be the
amounts to be received by the holder thereof and shall not, except as expressly
provided herein, be subject to any other obligation of the Company (or the
performance thereof).  The Company acknowledges that a breach by it of
its obligations hereunder will cause irreparable harm to the holders of the
Series B Preferred Stock and that the remedy at law for any such breach may be
inadequate.  The Company therefore agrees that, in the event of any
such breach or threatened breach, the holders of the Series B Preferred Stock
shall be entitled, in addition to all other available remedies, to an injunction
restraining any breach, without the necessity of showing economic loss and
without any bond or other security being required.

     

    
      
         

      

      
        9

        
          

        

      

      
         

      

    

     

    13.           Specific Shall Not Limit
General; Construction.  No specific provision contained in this
Certificate of Designation shall limit or modify any more general provision
contained herein.

     

    14.           Failure or Indulgence Not
Waiver.  No failure or delay on the part of a holder of Series
B Preferred Stock in the exercise of any power, right or privilege hereunder
shall operate as a waiver thereof, nor shall any single or partial exercise of
any such power, right or privilege preclude other or further exercise thereof or
of any other right, power or privilege.

     

    IN
WITNESS WHEREOF, the undersigned has executed and subscribed this Certificate
and does affirm the foregoing as true this 22  day of June,
2010.

    
      
        
          
            
              
                
                  
                    
                      	 
      	 
      	 
      	 
      	 
	 
      	
                              NEOPROBE
      CORPORATION

                            	 
	 
      	 
      	 
      	 
      	 
	 
      	
                              By:  

                            	
                              /s/ Brent L. Larson

                            	 
       
	 
      	 
      	
                              Name:

                            	
                              Brent L. Larson

                            	 
       
	 
      	 
      	
                              Title:

                            	
                              VP Finance/CFO

                            	 
       

                    

                  

                

              

            

          

        

      

    

    
      
         

      

      
        10

        
          

        

      

      
         

      

    

    EXHIBIT
I

    NEOPROBE
CORPORATION

    CONVERSION
NOTICE

    

    Reference is made to the Certificate of
Designation of the Relative Rights and Preferences of the Series B Preferred
Stock of Neoprobe Corporation (the “Certificate of
Designation”).  In accordance with and pursuant to the
Certificate of Designation, the undersigned hereby elects to convert the number
of shares of Series B Preferred Stock, par value $.001 per share (the “Preferred Shares”),
of Neoprobe Corporation, a Delaware corporation (the “Company”), indicated
below into shares of Common Stock, par value $.001 per share (the “Common Stock”), of
the Company, by tendering the stock certificate(s) representing the share(s) of
Preferred Shares specified below as of the date specified below.

    

    Date of
Conversion:                                                                                     

    

    Number of
Preferred Shares to be converted:                                                                                  

    

    Stock
certificate no(s). of Preferred Shares to be converted:                                                    

    

    The
Common Stock has been sold:  YES ___   NO ___

    

    Please
confirm the following information:

    

    Conversion
Rate:                          

    

    Number of
shares of Common Stock

    to be
issued:                                                                           

    

    Number of
shares of Common Stock beneficially owned or deemed beneficially owned by the
Holder on the Date of Conversion determined in accordance with Section 16 of the
Securities Exchange Act of 1934, as amended:                                                                                  

     

    Please
issue the Common Stock into which the Preferred Shares are being converted and,
if applicable, any check drawn on an account of the Company in the following
name and to the following address:

    

    Issue
to:                                                                                                 

    Facsimile
Number:                                                                                  

     

    Authorization:                                           

    By:                                                                           

    Title:                                                                        

    

    Dated:                                                                           

     

    
      
         

      

      
        11Exhibit
4.2

    

    NEOPROBE
CORPORATION

    

    CERTIFICATE
OF DESIGNATIONS, VOTING POWERS,

    PREFERENCES,
LIMITATIONS, RESTRICTIONS, AND RELATIVE

    RIGHTS
OF SERIES C CONVERTIBLE PREFERRED STOCK

     

    It is
hereby certified that:

    

    I.           The
name of the corporation is Neoprobe Corporation (the “Corporation”), a
Delaware corporation.

    

    II.           Set
forth hereinafter is a statement of the voting powers, preferences, limitations,
restrictions, and relative rights of shares of Series C Convertible Preferred
Stock hereinafter designated as contained in a resolution of the Board of
Directors of the Corporation pursuant to a provision of the Certificate of
Incorporation of the Corporation permitting the issuance of said Series C
Preferred Stock by resolution of the Board of Directors:

    

    1.           Designation and
Rank.

     

    (a)           Designation.  The
designation of such series of the Preferred Stock shall be the Series C
Convertible Preferred Stock, par value $.001 per share (the “Series C Preferred
Stock”).  The maximum number of shares of Series C Preferred
Stock shall be One Thousand (1,000) Shares.

     

    (b)           Rank.  The
Series C Preferred Stock shall rank prior to the common stock, par value $.001
per share (the “Common
Stock”), and to all other classes and series of equity securities of the
Company which by their terms do not rank on a parity with or senior to the
Series C Preferred Stock (“Junior
Stock”).  The Series C Preferred Stock shall rank senior to the
Series B Convertible Preferred Stock as to rights to cash dividends, and on a
parity with the Series B Convertible Preferred Stock as to distributions on
liquidation, dissolution or winding up.  The Series C Preferred Stock
shall be subordinate to and rank junior to all indebtedness of the Company now
or hereafter outstanding.

     

    2.           Dividends.

     

    (a)           Quarterly
Dividends.  The holders of shares of the Series C Preferred
Stock shall be entitled to receive, out of funds legally available therefor,
dividends at an annual rate equal to 10% of the Liquidation Preference Amount
(as defined below), whether or not declared.  Accrued and unpaid
dividends shall compound on a quarterly basis, and shall be, except as set forth
in Section 2(b) below, payable in cash.  The Board of Directors may
fix a record date for the determination of holders of shares of Series C
Preferred Stock entitled to receive payment of such dividends, which record date
shall not be more than sixty (60) days prior to the applicable dividend payment
date.  The first such dividend payment shall be due and payable on
September 30, 2010, with payments due and payable thereafter on June 30,
September 30, December 31 and March 31 of each year.   All
accrued and unpaid dividends, if any, shall be mandatorily paid immediately
prior to the earlier to occur of (i) a liquidation, dissolution or winding up
(or deemed liquidation, dissolution or winding up under Section 4(b) hereof) of
the Company (a “Liquidation”), or
(ii) a Voluntary Conversion pursuant to Section 5 hereof.

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    (b)           Payment of
Dividends.  At the option of the Company in compliance with
this Section 2(b), the Company may pay dividends on the Series C Preferred Stock
in registered shares of Common Stock, with each share of Common Stock being
valued for this purpose at 90% of the average VWAP for the five (5) trading days
immediately preceding the date on which such dividend is due and
payable.  Notwithstanding the above, no dividend shall be paid in
Common Stock (i) in connection with a Liquidation, or, (ii) unless the shares of
Common Stock received upon such payment shall be freely salable by the recipient
pursuant to a then effective registration statement under the Securities Act of
1933.  Certificates evidencing shares of Common Stock delivered as a
payment of dividends pursuant to this Section 2(b) shall be delivered to the
holders via no later than five (5) business days following the relevant dividend
payment date.  “VWAP” means, for any date, (i) the daily volume
weighted average price of the Common Stock for such date on the OTC Bulletin
Board (or national securities exchange, if applicable) as reported by Bloomberg
Financial L.P. (based on a trading day from 9:30 a.m. Eastern Time to 4:02 p.m.
Eastern Time); (ii) if the Common Stock is not then listed or quoted on the OTC
Bulletin Board (or national securities exchange, if applicable) and if prices
for the Common Stock are then reported in the “Pink Sheets” published by the
Pink Sheets, LLC (or a similar organization or agency succeeding to its
functions of reporting prices), the most recent bid price per share of the
Common Stock so reported; or (iii) in all other cases, the fair market value of
a share of Common Stock as determined by an independent appraiser selected in
good faith by the holder and reasonably acceptable to the Company.

     

    (c)           Junior Stock
Dividends.  The Company shall not declare or pay any cash
dividends on, or make any other distributions with respect to or redeem,
purchase or otherwise acquire for consideration, any shares of Junior Stock
unless and until all accrued and unpaid dividends on the Series C Preferred
Stock have been paid in full; provided that the foregoing
prohibition shall not apply to the repurchase, redemption or payment of
dividends or distributions on or with respect to the Series B Convertible
Preferred Stock in conformity with the designation of the powers, preferences,
limitations, restrictions, and relative rights
thereof.    In all events, Junior Stock dividends shall be
subject to the restrictions set forth in Section 3(a) below

     

    3.           Voting
Rights.

     

    (a)           Class Voting
Rights.  The Series C Preferred Stock shall have the following
class voting rights.  The Company shall not, without the affirmative
vote or consent of the holders of at least a majority of the shares of the
Series C Preferred Stock outstanding at the time, given in person or by proxy,
either in writing or at a meeting, in which the holders of the Series C
Preferred Stock vote separately as a class, amend, alter or repeal the
provisions of the Series C Preferred Stock so as to adversely affect any right,
preference, privilege or voting power of the Series C Preferred Stock. So long
as at least 25% of the shares of the Series C Preferred Stock remain
outstanding, the Company shall not, without the affirmative vote or consent of
the holders of at least a majority of the shares of the Series C Preferred Stock
outstanding at the time, given in person or by proxy, either in writing or at a
meeting, in which the holders of the Series C Preferred Stock vote separately as
a class: (i) repurchase, redeem or pay dividends on (whether in cash, in kind,
or otherwise), shares of the Company's Junior Stock; or (ii) effect any
distribution with respect to Junior Stock; provided that the foregoing
prohibition shall not apply to the repurchase, redemption or payment of
dividends or distributions on or with respect to the Series B Convertible
Preferred Stock in conformity with the designation of the powers, preferences,
limitations, restrictions, and relative rights thereof.

     

    (b)           General Voting
Rights.  Except with respect to transactions upon which the
Series C Preferred Stock shall be entitled to vote separately as a class
pursuant to Section 3(a) above, the Series C Preferred Stock shall have no
voting rights.  The Common Stock into which the Series C Preferred
Stock is convertible shall, upon issuance, have all of the same voting rights as
other issued and outstanding Common Stock of the Company.

     

    
      
         

      

      
        2

        
          

        

      

      
         

      

    

     

    4.           Liquidation
Preference.

     

    (a)           In
the event of the liquidation, dissolution or winding up of the affairs of the
Company, whether voluntary or involuntary, after payment or provision for
payment of the debts and other liabilities of the Company, the holders of shares
of the Series C Preferred Stock then outstanding shall be entitled to receive,
out of the assets of the Company, whether such assets are capital or surplus of
any nature, before any payment shall be made or any assets distributed to the
holders of the Common Stock or any other Junior Stock (but pari passu with any payment
to holders of Series B Convertible Preferred Stock), an amount per share of
Series C Preferred Stock calculated by taking the total amount available for
distribution to holders of all the Company’s outstanding Common Stock before
deduction of any preference payments for the Series B Convertible Preferred
Stock or Series C Preferred Stock, divided by the total of (x) all of the then
outstanding shares of the Company’s Common Stock, plus (y) all of the shares of
the Company’s Common Stock into which all of the outstanding shares of the
Series B Convertible Preferred Stock and Series C Preferred Stock can be
converted, and then (z) multiplying the sum so obtained by the number of shares
of Common Stock into which such share of Series C Preferred Stock could then be
converted (the “Liquidation Preference
Amount”).  The liquidation payment with respect to each
outstanding fractional share of Series C Preferred Stock shall be equal to a
ratably proportionate amount of the liquidation payment with respect to each
outstanding share of Series C Preferred Stock.  All payments for which
this Section 4(a) provides shall be in cash, property (valued at its fair market
value as determined by an independent appraiser reasonably acceptable to the
holders of a majority of the Series C Preferred Stock), or a combination
thereof; provided, however, that no cash shall be paid to holders of Junior
Stock unless each holder of the outstanding shares of Series C Preferred Stock
has been paid in cash the full Liquidation Preference Amount to which such
holder is entitled as provided herein.  After payment of the full
Liquidation Preference Amount to which each holder is entitled, such holders of
shares of Series C Preferred Stock will not be entitled to any further
participation as such in any distribution of the assets of the
Company.

     

    (b)           A
consolidation or merger of the Company with or into any other corporation or
corporations, or a sale of all or substantially all of the assets of the
Company, or the effectuation by the Company of a transaction or series of
transactions in which more than 50% of the voting shares of the Company is
disposed of or conveyed, shall be, at the election of the holders of a majority
of the Series C Preferred Stock, deemed to be a liquidation, dissolution, or
winding up within the meaning of this Section 4; provided, however, that any
such transaction shall not be deemed to be a liquidation, dissolution or winding
up unless such transaction is approved by the Board of Directors of the Company
and the holders of the Series C Preferred Stock do not control the Board of
Directors.  In the event of the merger or consolidation of the Company
with or into another corporation that is not treated as a liquidation pursuant
to this Section 4(b), the Series C Preferred Stock shall maintain its relative
powers, designations and preferences provided for herein (including any
adjustment required under Section 5(c)(v) hereof) and no merger shall result
inconsistent therewith.

     

    (c)           Written
notice of any voluntary or involuntary liquidation, dissolution or winding up of
the affairs of the Company, stating a payment date and the place where the
distributable amounts shall be payable, shall be given by mail, postage prepaid,
no less than forty-five (45) days prior to the payment date stated therein, to
the holders of record of the Series C Preferred Stock at their respective
addresses as the same shall appear on the books of the Company.

     

    5.           Conversion.  The
holders of Series C Preferred Stock shall have the following conversion rights
(the “Conversion
Rights”):

     

    
      
         

      

      
        3

        
          

        

      

      
         

      

    

    (a)           Right to
Convert.  At any time on or after the date of issuance of the
Series C Preferred Stock (the “Issuance Date”), the
holder of any such shares of Series C Preferred Stock may, at such holder’s
option, elect to convert (a “Voluntary
Conversion”) all or any portion of the shares of Series C Preferred Stock
held by such person into a number of fully paid and nonassessable shares of
Common Stock at a
conversion rate of 3,226 shares of Common Stock for each share of Preferred
Stock (subject to adjustments set forth in Section 5(c) herein, the “Conversion
Rate”).  The Company shall keep written records of the
conversion of the shares of Series C Preferred Stock converted by each
holder.  A holder shall be required to deliver the original
certificates representing the shares of Series C Preferred Stock upon any
conversion of the Series C Preferred Stock as provided in Section 5(b)
below.

     

    (b)           Mechanics of Voluntary
Conversion.  The Voluntary Conversion of Series C Preferred
Stock shall be conducted in the following manner:

     

    (i)  Holder's Delivery
Requirements.  To convert Series C Preferred Stock into full
shares of Common Stock on any date (the “Voluntary Conversion
Date”), the holder thereof shall (A) transmit by facsimile (or otherwise
deliver), for receipt on or prior to 5:00 p.m., Eastern Time on such date, a
copy of a fully executed notice of conversion in the form attached hereto
as  Exhibit I  (the “Conversion Notice”),
to the Company, and (B) with respect to the final conversion of shares of Series
C Preferred Stock held by any holder, such holder shall surrender to a common
carrier for delivery to the Company as soon as practicable following such
Conversion Date but in no event later than six (6) business days after such date
the original certificates representing the shares of Series C Preferred Stock
being converted (or an indemnification undertaking with respect to such shares
in the case of their loss, theft or destruction) (the “Preferred Stock
Certificates”).

     

    (ii)  Company's
Response.  Upon receipt by the Company of a facsimile copy of a
Conversion Notice, the Company shall immediately send, via facsimile, a
confirmation of receipt of such Conversion Notice to such holder and the Company
or its designated transfer agent (the “Transfer Agent”), as
applicable, shall, within five (5) business days following the date of receipt
by the Company of the certificate representing the shares of Series C Preferred
Stock being converted, (x) issue and deliver to the Depository Trust Company
(“DTC”) account
on the holder’s behalf via the Deposit Withdrawal Agent Commission System
(“DWAC”) as
specified in the Conversion Notice, registered in the name of the holder or its
designee, for the number of shares of Common Stock to which the holder shall be
entitled, and (y) if the certificate so surrendered represents more shares of
Series C Preferred Stock than those being converted, issue and deliver to the
holder a new certificate for such number of shares of Series C Preferred Stock
represented by the surrendered certificate which were not converted.
Simultaneously, the Company will pay the holder any dividends that are accrued
and unpaid as of the Voluntary Conversion Date on the shares of Series C
Preferred Stock being converted, either in cash, or at the option of the Company
in shares of Common Stock as provided in Section 2(b) hereof.

     

    (iii)  Record Holder.  The
person or persons entitled to receive the shares of Common Stock issuable upon a
conversion of the Series C Preferred Stock shall be treated for all purposes as
the record holder or holders of such shares of Common Stock on the Conversion
Date.

     

    (iv)  Company's Failure to Timely
Convert.  If within five (5) business days of the Company's
receipt of the Conversion Notice (the “Share Delivery
Period”) the Company shall fail to issue and deliver to a holder the
number of shares of Common Stock to which such holder is entitled upon such
holder's conversion of the Series C Preferred Stock (a “Conversion Failure”),
in addition to all other available remedies which such holder may pursue
hereunder, the Company shall pay additional damages to such holder on each
business day after such fifth (5th) business day that such conversion is not
timely effected in an amount equal to 0.5% of the product of (A) the sum of the
number of shares of Common Stock not so issued to the holder on a timely basis
pursuant to Section 5(b)(ii) and to which such holder is entitled and (B) the
closing bid price of the Common Stock on the last possible date which the
Company could have issued such Common Stock to such holder without violating
Section 5(b)(ii).  If the Company fails to pay the additional damages
set forth in this Section 5(b)(iv) within five (5) business days of the date
incurred, then such payment shall bear interest at the rate of 2% per month (pro
rated for partial months) until such payments are made.

     

    
      
         

      

      
        4

        
          

        

      

      
         

      

    

     

    (c)     Adjustments of Conversion
Rate.

     

    (i)   Adjustments for Stock Splits and
Combinations.  If the Company shall at any time or from time to
time after the Issuance Date, effect a stock split of the outstanding Common
Stock, the Conversion Rate shall be proportionately increased.  If the
Company shall at any time or from time to time after the Issuance Date, combine
the outstanding shares of Common Stock, the Conversion Rate shall be
proportionately decreased.  Any adjustments under this Section 5(e)(i)
shall be effective at the close of business on the date the stock split or
combination occurs.

     

    (ii)  Adjustments for Certain Dividends
and Distributions.  If the Company shall at any time or from
time to time after the Issuance Date, make or issue or set a record date for the
determination of holders of Common Stock entitled to receive a dividend or other
distribution payable in shares of Common Stock, then, and in each event, the
Conversion Rate shall be increased as of the time of such issuance or, in the
event such record date shall have been fixed, as of the close of business on
such record date, by multiplying, as applicable, the Conversion Rate then in
effect by a fraction:

     

    (A)      the
numerator of which shall be the total number of shares of Common Stock issued
and outstanding immediately following the time of such issuance or the close of
business on such record date; and

     

    (B)       the
denominator of which shall be the total number of shares of Common Stock issued
and outstanding immediately prior to the time of such issuance.

     

    (iii)  Adjustment for Other Dividends and
Distributions.  If the Company shall at any time or from time
to time after the Issuance Date, make or issue or set a record date for the
determination of holders of Common Stock entitled to receive a dividend or other
distribution payable in securities of the Company other than shares of Common
Stock, then, and in each event, an appropriate revision to the applicable
Conversion Rate shall be made and provision shall be made (by adjustments of the
Conversion Rate or otherwise) so that the holders of Series C Preferred Stock
shall receive upon conversions thereof, in addition to the number of shares of
Common Stock receivable thereon, the number of securities of the Company which
they would have received had their Series C Preferred Stock been converted into
Common Stock on the date of such event and had thereafter, during the period
from the date of such event to and including the Conversion Date, retained such
securities (together with any distributions payable thereon during such period),
giving application to all adjustments called for during such period under this
Section 5(c)(iii) with respect to the rights of the holders of the Series C
Preferred Stock.

     

    (iv)  Adjustments for Reclassification,
Exchange or Substitution.  If the Common Stock issuable upon
conversion of the Series C Preferred Stock at any time or from time to time
after the Issuance Date shall be changed to the same or different number of
shares of any class or classes of stock, whether by reclassification, exchange,
substitution or otherwise (other than by way of a stock split or combination of
shares or stock dividends provided for in Sections 5(c)(i), (ii) and (iii), or a
reorganization, merger, consolidation, or sale of assets provided for in Section
5(c)(v)), then, and in each event, an appropriate revision to the Conversion
Rate shall be made and provisions shall be made so that the holder of each share
of Series C Preferred Stock shall have the right thereafter to convert such
share of Series C Preferred Stock into the kind and amount of shares of stock
and other securities receivable upon reclassification, exchange, substitution or
other change, by holders of the number of shares of Common Stock into which such
share of Series C Preferred Stock might have been converted immediately prior to
such reclassification, exchange, substitution or other change, all subject to
further adjustment as provided herein.

     

    
      
         

      

      
        5

        
          

        

      

      
         

      

    

     

    (v)  Adjustments for Reorganization,
Merger, Consolidation or Sales of Assets.  If at any time or
from time to time after the Issuance Date there shall be a capital
reorganization of the Company (other than by way of a stock split or combination
of shares or stock dividends or distributions provided for in Section 5(c)(i),
(ii) and (iii), or a reclassification, exchange or substitution of shares
provided for in Section 5(c)(iv)), or a merger or consolidation of the Company
with or into another corporation, or the sale of all or substantially all of the
Company's properties or assets to any other person that is not deemed a
liquidation pursuant to Section 4(b) (an “Organic Change”),
then as a part of such Organic Change an appropriate revision to the Conversion
Rate  shall be made and provision shall be made so that the holder of
each share of Series C Preferred Stock shall have the right thereafter to
convert such share of Series C Preferred Stock into the kind and amount of
shares of stock and other securities or property of the Company or any successor
corporation resulting from the Organic Change as the holder would have received
as a result of the Organic Change and if the holder had converted its Series C
Preferred Stock into the Company’s Common Stock prior to the Organic
Change.

     

    (vi)  Record Date.  In
case the Company shall take record of the holders of its Common Stock or any
other Preferred Stock for the purpose of entitling them to subscribe for or
purchase Common Stock or Convertible Securities, then the date of the issue or
sale of the shares of Common Stock shall be deemed to be such record
date.

     

    (d)           No
Impairment.  The Company shall not, by amendment of its
Certificate of Incorporation or through any reorganization, transfer of assets,
consolidation, merger, dissolution, issue or sale of securities or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the terms to be observed or performed hereunder by the Company, but will at all
times in good faith, assist in the carrying out of all the provisions of this
Section 5 and in the taking of all such action as may be necessary or
appropriate in order to protect the Conversion Rights of the holders of the
Series C Preferred Stock against impairment. In the event a holder shall elect
to convert any shares of Series C Preferred Stock as provided herein, the
Company cannot refuse conversion based on any claim that such holder or anyone
associated or affiliated with such holder has been engaged in any violation of
law, unless an injunction from a court, on notice, restraining and/or adjoining
conversion of all or of said shares of Series C Preferred Stock shall have been
issued.

     

    (e)           Certificates as to
Adjustments.  Upon occurrence of each adjustment or
readjustment of the Conversion Rate or number of shares of Common Stock issuable
upon conversion of the Series C Preferred Stock pursuant to this Section 5, the
Company at its expense shall promptly compute such adjustment or readjustment in
accordance with the terms hereof and furnish to each holder of such Series C
Preferred Stock a certificate setting forth such adjustment and readjustment,
showing in detail the facts upon which such adjustment or readjustment is
based.  The Company shall, upon written request of the holder of such
affected Series C Preferred Stock, at any time, furnish or cause to be furnished
to such holder a like certificate setting forth such adjustments and
readjustments, the Conversion Rate in effect at the time, and the number of
shares of Common Stock and the amount, if any, of other securities or property
which at the time would be received upon the conversion of a share of such
Series C Preferred Stock.  Notwithstanding the foregoing, the Company
shall not be obligated to deliver a certificate unless such certificate would
reflect an increase or decrease of at least one percent (1%) of such adjusted
amount.

     

    
      
         

      

      
        6

        
          

        

      

      
         

      

    

    (f)           Issue
Taxes.  The Company shall pay any and all issue and other
taxes, excluding federal, state or local income taxes, that may be payable in
respect of any issue or delivery of shares of Common Stock on conversion of
shares of Series C Preferred Stock pursuant thereto;  provided,  however,
that the Company shall not be obligated to pay any transfer taxes resulting from
any transfer requested by any holder in connection with any such
conversion.

     

    (g)           Notices.  Any
notice, demand, request, waiver or other communication required or permitted to
be given hereunder shall be in writing and shall be effective (i) upon hand
delivery, telecopy or facsimile at the address or number designated in the
Exchange Agreement (if delivered on a business day during normal business hours
where such notice is to be received), or the first business day following such
delivery (if delivered other than on a business day during normal business hours
where such notice is to be received) or (ii) on the second business day
following the date of mailing by express overnight courier service, fully
prepaid, addressed to such address, or upon actual receipt of such mailing,
whichever shall first occur. The Company will give written notice each holder of
Series C Preferred Stock at least ten (10) days prior to the date on which the
Company takes a record (A) with respect to any dividend or distribution upon the
Common Stock, (B) with respect to any pro rata subscription offer to holders of
Common Stock or (C) for determining rights to vote with respect to any Organic
Change, dissolution, liquidation or winding-up and in no event shall such notice
be provided to such holder prior to such information being made known to the
public. Subject to Section 4(c), the Company will also give written notice to
each holder of Series C Preferred Stock at least ten (10) days prior to the date
on which any Organic Change will take place and in no event shall such notice be
provided to such holder  prior to such information being made known to
the public

     

    (h)           Fractional
Shares.  No fractional shares of Common Stock shall be issued
upon conversion of the Series C Preferred Stock.  In lieu of any
fractional shares to which the holder would otherwise be entitled, the Company
shall at its option either (i) pay cash equal to the product of such fraction
multiplied by the average of the closing bid prices of the Common Stock for the
five (5) consecutive trading days immediately preceding the Voluntary Conversion
Date, as applicable, or (ii) in lieu of issuing such fractional shares issue one
additional whole share to the holder.

     

    (i)           Reservation of Common
Stock.  The Company shall, so long as any shares of Series C
Preferred Stock are outstanding, reserve and keep available out of its
authorized and unissued Common Stock, solely for the purpose of effecting the
conversion of the Series C Preferred Stock, such number of shares of Common
Stock as shall from time to time be sufficient to effect the conversion of all
of the Series C Preferred Stock then outstanding.

     

    (j)           Retirement of Series C
Preferred Stock.  Conversion of Series C Preferred Stock shall
be deemed to have been effected on the applicable Voluntary Conversion
Date.  The Company shall keep written records of the conversion of the
shares of Series C Preferred Stock converted by each holder.  A holder
shall be required to deliver the original certificates representing the shares
of Series C Preferred Stock upon complete conversion of the Series C Preferred
Stock represented by such certificates. A delivery of original
certificates pursuant to Section 5(b)(i) shall be deemed to comply with the
requirements of this Section 5(j).

     

    (k)           Regulatory
Compliance.  If any shares of Common Stock to be reserved for
the purpose of conversion of Series C Preferred Stock require registration or
listing with or approval of any governmental authority, stock exchange or other
regulatory body under any federal or state law or regulation or otherwise before
such shares may be validly issued or delivered upon conversion, the Company
shall, at its sole cost and expense, in good faith and as expeditiously as
possible, endeavor to secure such registration, listing or approval, as the case
may be.

     

    
      
         

      

      
        7

        
          

        

      

      
         

      

    

     

    6.           No Preemptive
Rights.  Except as provided in Section 5 hereof, no holder of
the Series C Preferred Stock shall be entitled to rights to subscribe for,
purchase or receive any part of any new or additional shares of any class,
whether now or hereinafter authorized, or of bonds or debentures, or other
evidences of indebtedness convertible into or exchangeable for shares of any
class, but all such new or additional shares of any class, or any bond,
debentures or other evidences of indebtedness convertible into or exchangeable
for shares, may be issued and disposed of by the Board of Directors on such
terms and for such consideration (to the extent permitted by law), and to such
person or persons as the Board of Directors in their absolute discretion may
deem advisable.

     

    7.           Inability to Fully
Convert.

     

    (a)           Holder's Option if Company
Cannot Fully Convert.  If, upon the Company's receipt of a
Conversion Notice, the Company cannot issue shares of Common Stock for any
reason, including, without limitation, because the Company (i) does not have a
sufficient number of shares of Common Stock authorized and available, or (ii) is
otherwise prohibited by applicable law or by the rules or regulations of any
stock exchange, interdealer quotation system or other self-regulatory
organization with jurisdiction over the Company or its securities from issuing
all of the Common Stock which is to be issued to a holder of Series C Preferred
Stock pursuant to a Conversion Notice, then the Company shall issue as many
shares of Common Stock as it is able to issue in accordance with such holder's
Conversion Notice, and with respect to the unconverted Series C Preferred Stock
(the “Unconverted
Preferred Stock”), the holder, solely at such holder's option, can elect
to, at any time after receipt of notice from the Company that there is
Unconverted Preferred Stock, to void the holder’s Conversion Notice as to the
number of shares of Common Stock the Company is unable to issue and retain or
have returned, as the case may be, the certificates for the shares of the
Unconverted Preferred Stock.

     

    (b)           Mechanics of Fulfilling
Holder's Election.  The Company shall immediately send via
facsimile to a holder of Series C Preferred Stock, upon receipt of a facsimile
copy of a Conversion Notice from such holder which cannot be fully satisfied as
described in Section 7(a) above, a notice of the Company's inability to fully
satisfy such holder's Conversion Notice (the “Inability to Fully Convert
Notice”).  Such Inability to Fully Convert Notice shall
indicate (i) the reason why the Company is unable to fully satisfy such holder's
Conversion Notice, and (ii) the number of shares of Series C Preferred Stock
which cannot be converted.

     

    8.           Automatic
Conversion.

     

    (a)           Automatic Conversion
Events.  All outstanding shares of Series C Preferred Stock
shall be automatically converted into Common Stock at the Conversion Rate upon
the earlier to occur of (i) the closing of a firm commitment underwritten public
offering of Common Stock of the Company pursuant to an effective registration
statement under Section 5 of the Securities Act  in which the gross
cash proceeds to the Company (before underwriting discounts, commissions and
fees) from such public offering are at least $10,000,000, or (ii) December 31,
2012 (each, an “Automatic Conversion
Event”).

     

    
      
         

      

      
        8

        
          

        

      

      
         

      

    

    (b)           Mechanics of Automatic
Conversion.  Upon the occurrence of an Automatic Conversion
Event, the outstanding Series C Preferred Stock shall be converted into Common
Stock automatically without any further action by the holders of such shares and
whether or not the certificates representing such shares are surrendered to the
Company or its transfer agent; provided, however, that the Company shall not be
obligated to issue certificates evidencing the Common Stock issuable upon such
conversion unless the certificates evidencing such Series C Preferred Stock are
either delivered to the Company or its transfer agent as provided below, or the
holder certifies to the Company or its transfer agent that such certificates
have been lost, stolen or destroyed and executes an agreement satisfactory to
the Company to indemnify the Company from any loss incurred by it in connection
with such certificates. Upon surrender by any holder of the certificates
formerly representing shares of Series C Preferred Stock to the Company or the
transfer agent, there shall be issued and delivered to such holder promptly in
its name as shown on such surrendered certificate or certificates, a certificate
or certificates for the number of shares of Common Stock into which the shares
of Series C Preferred Stock surrendered were converted on the date on which such
automatic conversion occurred, and the Company shall promptly pay in cash (at
the fair market value per share of Common Stock determined by the Board of
Directors as of the date of conversion) the value of any fractional share of
Common Stock otherwise issuable to any holder of shares of Series C Preferred
Stock being converted. Until surrendered as provided above, each certificate
formerly representing Series C Preferred Stock shall be deemed for all corporate
purposes to represent the number of shares of Common Stock resulting from such
automatic conversion.

     

    (c)           Inability to
Convert.  Notwithstanding the provisions of Section 8(a) if,
upon the occurrence of an Automatic Conversion Event, the Company cannot issue
shares of Common Stock to fully effect the conversion for any reason, including,
without limitation, because the Company (i) does not have a sufficient number of
shares of Common Stock authorized and available, or (ii) is otherwise prohibited
by applicable law or by the rules or regulations of any stock exchange,
interdealer quotation system or other self-regulatory organization with
jurisdiction over the Company or its securities from issuing all of the Common
Stock which is to be issued to a holder of Series C Preferred Stock, then the
Company shall issue as many shares of Common Stock as it is able to issue, and
with respect to the unconverted Series C Preferred Stock (the “Unconverted Preferred
Stock”), deliver to the holder a certificate for the shares of the
Unconverted Preferred Stock.  In the event that the Company is
thereafter able to convert the Unconverted Preferred Stock, it shall so notify
the holder in writing, and such notice shall be deemed to be an Automatic
Conversion Event for purposes of this Section 8.

     

    9.           Vote to Change the Terms of
Preferred Stock.  The affirmative vote at a meeting duly called
for such purpose, or the written consent without a meeting, of the holders of
not less than a majority of the then outstanding shares of Series C Preferred
Stock, shall be required for any change to this Certificate of Designation or
the Company’s Certificate of Incorporation that would amend, alter, change or
repeal any of the powers, designations, preferences and rights of the Series C
Preferred Stock.

     

    10.           Lost or Stolen
Certificates.  Upon receipt by the Company of evidence
satisfactory to the Company of the loss, theft, destruction or mutilation of any
certificates representing the shares of Series C Preferred Stock, and, in the
case of loss, theft or destruction, of any indemnification undertaking by the
holder to the Company and, in the case of mutilation, upon surrender and
cancellation of such certificate(s), the Company shall execute and deliver new
preferred stock certificate(s) of like tenor and date.

     

    11.           Remedies, Characterizations,
Other Obligations, Breaches and Injunctive Relief.  The
remedies provided in this Certificate of Designation shall be cumulative and in
addition to all other remedies available under this Certificate of Designation,
at law or in equity (including a decree of specific performance and/or other
injunctive relief), no remedy contained herein shall be deemed a waiver of
compliance with the provisions giving rise to such remedy and nothing herein
shall limit a holder's right to pursue actual damages for any failure by the
Company to comply with the terms of this Certificate of
Designation.  Amounts set forth or provided for herein with respect to
payments, conversion and the like (and the computation thereof) shall be the
amounts to be received by the holder thereof and shall not, except as expressly
provided herein, be subject to any other obligation of the Company (or the
performance thereof).  The Company acknowledges that a breach by it of
its obligations hereunder will cause irreparable harm to the holders of the
Series C Preferred Stock and that the remedy at law for any such breach may be
inadequate.  The Company therefore agrees that, in the event of any
such breach or threatened breach, the holders of the Series C Preferred Stock
shall be entitled, in addition to all other available remedies, to an injunction
restraining any breach, without the necessity of showing economic loss and
without any bond or other security being required.

     

    
      
         

      

      
        9

        
          

        

      

      
         

      

    

     

    12.           Specific Shall Not Limit
General; Construction.  No specific provision contained in this
Certificate of Designation shall limit or modify any more general provision
contained herein.

     

    13.           Failure or Indulgence Not
Waiver.  No failure or delay on the part of a holder of Series
C Preferred Stock in the exercise of any power, right or privilege hereunder
shall operate as a waiver thereof, nor shall any single or partial exercise of
any such power, right or privilege preclude other or further exercise thereof or
of any other right, power or privilege.

     

    IN WITNESS WHEREOF, the undersigned has
executed and subscribed this Certificate and does affirm the foregoing as true
this 22nd day of June, 2010.

    

    
      
        
          
            
              
                
                  	 
      	
                          NEOPROBE
      CORPORATION

                        
	 
      	 
      	 	 
      	 
      
	   
      	
                          By:  

                        	/s/
      Brent L. Larson	   
      
	   
      	
                           
      

                        	

                          Name: 

                        	
                          Brent
      L. Larson

                        	 
      
	   
      	
                           
      

                        	

                          Title:   

                        	
                          VP
      Finance/CFO

                        	 
      

                

              

            

          

        

      

    

    
      
         

      

      
        10

        
          

        

      

      
         

      

    

    EXHIBIT
I

    NEOPROBE
CORPORATION

    CONVERSION
NOTICE

    

    Reference is made to the Certificate of
Designation of the Relative Rights and Preferences of the Series C Preferred
Stock of Neoprobe Corporation (the “Certificate of
Designation”).  In accordance with and pursuant to the
Certificate of Designation, the undersigned hereby elects to convert the number
of shares of Series C Preferred Stock, par value $.001 per share (the “Preferred Shares”),
of Neoprobe Corporation, a Delaware corporation (the “Company”), indicated
below into shares of Common Stock, par value $.001 per share (the “Common Stock”), of
the Company, by tendering the stock certificate(s) representing the share(s) of
Preferred Shares specified below as of the date specified below.

    

    Date of
Conversion:                                                                               

    

    Number of
Preferred Shares to be converted:                                                             

    

    Stock
certificate no(s). of Preferred Shares to be converted:                                                        

    

    The
Common Stock has been sold:  YES ___   NO ___

    

    Please
confirm the following information:

    

    Conversion
Rate:                                 

    

    Number of
shares of Common Stock

    to be
issued:                                                                           

    

    Number of
shares of Common Stock beneficially owned or deemed beneficially owned by the
Holder on the Date of Conversion determined in accordance with Section 16 of the
Securities Exchange Act of 1934, as amended:
___________________________

    

    Please
issue the Common Stock into which the Preferred Shares are being converted and,
if applicable, any check drawn on an account of the Company in the following
name and to the following address:

    

    Issue
to:                                                                               

    Facsimile
Number:                                                              

     

    Authorization:                                           

    By:                                                                           

    Title:
___________________________________ 

    

    Dated:                                                                        

    
      
         

      

      
        11

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