Document:

Exhibit 4.1

 

 

ANNUAL INFORMATION FORM

 

FOR THE YEAR ENDED MARCH 31, 2020

 

www.medicenna.com

 

Unless otherwise indicated, all information
in the Annual Information Form

is presented as at and for the year ended
March 31, 2020

 

May 14, 2020

 

    

     

    

 

TABLE OF CONTENTS

 

	INTRODUCTION AND FORWARD-LOOKING STATEMENTS	 	1
	 	 	 
	Corporate structure	 	4
	 	 	 
	GENERAL DEVELOPMENT OF THE BUSINESS	 	5
	 	 	 
	narrative description of the Business	 	10
	 	 	 
	RISK FACTORS	 	38
	 	 	 
	DIVIDENDS	 	54
	 	 	 
	SHARE CAPITAL	 	54
	 	 	 
	MARKET FOR SECURITIES	 	55
	 	 	 
	BOARD OF DIRECTORS AND MANAGEMENT	 	55
	 	 	 
	CEASE TRADE ORDERS, BANKRUPTCIES, PENALTIES OR SANCTIONS	 	59
	 	 	 
	CONFLICTS OF INTEREST	 	60
	 	 	 
	LEGAL PROCEEDINGS and regulatory actions	 	60
	 	 	 
	INTEREST OF MANAGEMENT AND OTHERS IN MATERIAL TRANSACTIONS	 	60
	 	 	 
	TRANSFER AGENT	 	60
	 	 	 
	MATERIAL CONTRACTS	 	61
	 	 	 
	INTEREST OF EXPERTS	 	61
	 	 	 
	ADDITIONAL INFORMATION	 	61
	 	 	 
	Schedule A audit committee information	 	62
	 	 	 
	Appendix 1 AUDIT COMMITTEE CHARTER	 	64

 

    

     

    

 

INTRODUCTION
AND FORWARD-LOOKING STATEMENTS

 

The information contained in this Annual
Information Form (this “AIF”) is stated as at March 31, 2020, unless otherwise indicated.

 

All references in this AIF to “the
Company”, “Medicenna”, “we”, “us”, or “our” refer to Medicenna Therapeutics
Corp. and the subsidiaries through which it conducts its business, unless otherwise indicated.

 

All amounts are in Canadian dollars, unless
otherwise indicated.

 

This AIF contains forward-looking statements
within the meaning of applicable securities laws. These statements involve known and unknown risks, uncertainties and other factors
which may cause the actual results, performance or achievements of the Company, or industry results, to be materially different
from any future results, performance or achievements expressed or implied by such forward-looking statements. All statements contained
herein that are not clearly historical in nature are forward-looking, and the words such as “plan”, “expect”,
 “is expected”, “budget”, “scheduled”, “estimate”, “forecast”, “contemplate”,
 “intend”, “anticipate”, or “believe” or variations (including negative variations) of such
words and phrases, or statements that certain actions, events or results “may”, “could”, “would”,
 “might”, “shall” or “will” be taken, occur or be achieved and similar expressions are generally
intended to identify forward-looking statements. Forward-looking statements in this AIF include, but are not limited to, statements
with respect to the Company’s:

 

		·	requirements for, and the ability to obtain,
future funding on favourable terms or at all;

		·	business strategy;

		·	expected future loss and accumulated deficit
levels;

		·	projected financial position and estimated
cash burn rate;

		·	expectations about the timing of achieving
milestones and the cost of the Company’s development programs;

		·	observations and expectations regarding
the effectiveness of MDNA55 and the potential benefits to patients;

		·	expectations about the Company’s
products’ safety and efficacy;

		·	expectations regarding the Company’s
ability to arrange for the manufacturing of the Company’s products and technologies;

		·	expectations regarding the progress, and
the successful and timely completion, of the various stages of the regulatory approval process;

		·	ability to secure strategic partnerships
with larger pharmaceutical and biotechnology companies;

		·	strategy to acquire and develop new products
and technologies and to enhance the safety and efficacy of existing products and technologies;

		·	plans to market, sell and distribute the
Company’s products and technologies;

		·	expectations regarding the acceptance
of the Company’s products and technologies by the market;

		·	ability to retain and access appropriate
staff, management, and expert advisers;

		·	expectations with respect to existing
and future corporate alliances and licensing transactions with third parties, and the receipt and timing of any payments to be
made by the Company or to the Company in respect of such arrangements; and

		·	strategy with respect to the protection
of the Company’s intellectual property.

 

    

     

    

 

All forward-looking statements reflect
the Company’s beliefs and assumptions based on information available at the time the assumption was made. These forward-looking
statements are not based on historical facts but rather on management’s expectations regarding future activities, results
of operations, performance, future capital and other expenditures (including the amount, nature and sources of funding thereof),
competitive advantages, business prospects and opportunities. By its nature, forward-looking information involves numerous assumptions,
inherent risks and uncertainties, both general and specific, known and unknown, that contribute to the possibility that the predictions,
forecasts, projections or other forward-looking statements will not occur. Factors which could cause future outcomes to differ
materially from those set forth in the forward-looking statements include, but are not limited to:

 

		·	the effect of continuing operating losses
on the Company’s ability to obtain, on satisfactory terms, or at all, the capital required to maintain the Company as a going
concern;

		·	the ability to obtain sufficient and suitable
financing to support operations, preclinical development, clinical trials, and commercialization of products;

		·	the risks associated with the development
of novel compounds at early stages of development in the Company’s intellectual property portfolio;

		·	the risks of reliance on third-parties
for the planning, conduct and monitoring of clinical trials and for the manufacture of drug product;

		·	the risks associated with the development
of the Company’s product candidates including the demonstration of efficacy and safety;

		·	the risks related to clinical trials including
potential delays, cost overruns and the failure to demonstrate efficacy and safety;

		·	the risks of delays and inability to complete
clinical trials due to difficulties enrolling patients;

		·	risks associated with the Company’s
inability to successfully develop companion diagnostics for the Company’s development candidates;

		·	delays or negative outcomes from the regulatory
approval process;

		·	the Company’s ability to successfully
compete in the Company’s targeted markets;

		·	the Company’s ability to attract
and retain key personnel, collaborators and advisors;

		·	risks relating to the increase in operating
costs from expanding existing programs, acquisition of additional development programs and increased staff;

		·	risk of negative results of clinical trials
or adverse safety events by the Company or others related to the Company’s product candidates;

		·	the potential for product liability claims;

		·	the Company’s ability to achieve
the Company’s forecasted milestones and timelines on schedule;

		·	financial risks related to the fluctuation
of foreign currency rates and expenses denominated in foreign currencies;

		·	the Company’s ability to adequately
protect proprietary information and technology from competitors;

		·	risks related to changes in patent laws
and their interpretations;

		·	the Company’s ability to source
and maintain licenses from third-party owners; and

		·	the risk of patent-related litigation
and the ability to protect trade secrets,

 

all as further and more fully described
under the section of this AIF titled “Risk Factors”. Although the Company has attempted to identify important factors
that could cause actual actions, events or results to differ materially from those described in forward-looking statements, there
may be other factors that cause actions, events or results to differ from those anticipated, estimated or intended.

 

    2

     

    

 

The forward looking information in this
AIF does not include a full assessment or reflection of the unprecedented impacts of the COVID-19 pandemic occurring in the first
quarter of 2020 and the ongoing and developing resulting indirect global and regional economic impacts. The Company is currently
experiencing uncertainty related to the rapidly developing COVID-19 situation. It is anticipated that the spread of COVID-19 and
global measures to contain it, will have an impact on the Company, however it is challenging to quantify the potential magnitude
of such impact at this time. The Company is regularly assessing the situation and remains in contact with its partners, clinical
sites and investigators, contract research organizations, contract development
and manufacturing organizations and suppliers to assess any impacts and risks.

 

Although the forward-looking statements
contained in this AIF are based upon what the Company’s management believes to be reasonable assumptions, the Company cannot
assure readers that actual results will be consistent with these forward-looking statements.

 

Any forward-looking statements represent
the Company’s estimates only as of the date of this AIF and should not be relied upon as representing the Company’s
estimates as of any subsequent date. The Company undertakes no obligation to update any forward-looking statement or statements
to reflect events or circumstances after the date on which such statement is made or to reflect the occurrence of unanticipated
events, except as may be required by securities laws.

 

    3

     

    

 

Corporate
structure

 

Corporate Information

 

Medicenna, formerly A2 Acquisition Corp.
(“A2”), is the resulting issuer following a “three-cornered” amalgamation involving A2, 1102209 B.C. Ltd.
(“A2 Sub”), a wholly owned subsidiary of A2 incorporated pursuant to the Business Corporations Act (British
Columbia) (“BCBCA”), and Medicenna Therapeutics Inc. (“MTI”), completed on March 1, 2017.

 

A2 was formed by articles of incorporation
under the Business Corporations Act (Alberta) (“ABCA”) on February 2, 2015, and following its initial public
offering, was a capital pool company (“CPC”) listed on the TSX Venture Exchange (“TSXV”). As a CPC, A2
had no assets other than cash and did not carry on any operations other than identifying and evaluating opportunities for the acquisition
of an interest in assets or businesses for the completion of a qualifying transaction.

 

On March 1, 2017, A2 completed its
qualifying transaction in accordance with the policies of the TSXV by way of reverse takeover of A2 by the shareholders of MTI
(the “Qualifying Transaction”). In addition, on March 1, 2017 and prior to the completion of the Qualifying Transaction,
the Company amended its articles as a result of (a) implementing a consolidation (the “Consolidation”) of its
pre-Qualifying Transaction common shares (the “A2 Shares”) on the basis of one new common share of the Company (each,
a “Common Share”) for every fourteen A2 Shares (1:14) and (b) changing its name to Medicenna Therapeutics Corp.

 

On August 2, 2017 Medicenna graduated
to the main board of the Toronto Stock Exchange (“TSX”). On November 13, 2017, Medicenna continued under the Canada
Business Corporations Act (“CBCA”).

 

Medicenna’s head and registered office
is located at 2 Bloor Street W, 7th Floor, Toronto, Ontario, M4W 3E2.

 

Intercorporate Relationships

 

MTI is a wholly owned subsidiary of Medicenna
and was incorporated pursuant to the provisions of the BCBCA on October 31, 2011. MTI has two wholly owned subsidiaries: Medicenna
Biopharma Inc. (British Columbia) and Medicenna Biopharma Inc. (Delaware). MTI’s head office is located at 2 Bloor Street
W, 7th Floor, Toronto, Ontario, M4W 3E2, and its registered office is at 439 Helmcken Street, Vancouver, British Columbia,
V6B 2E6.

 

Medicenna Biopharma Inc. (British Columbia)
was incorporated under the BCBCA on October 5, 2012. Its registered office is located at 439 Helmcken Street, Vancouver, British
Columbia, V6B 2E6 and its head office is at 2 Bloor Street W, 7th Floor, Toronto, Ontario, M4W 3E2.

 

Medicenna Biopharma Inc. (Delaware) was
incorporated in the State of Delaware on July 1, 2014. Its registered office is located at 1209 Orange Street, Wilmington,
New Castle County, Delaware 19801 and its head office is at 1700 Post Oak Blvd, Suite 600, Houston, Texas 77056.

 

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The following organizational chart demonstrates
the corporate structure of the Company:

 

 

GENERAL
DEVELOPMENT OF THE BUSINESS

 

Year ended March 31, 2018

 

In April 2017, the Company announced
that it had treated the first patient in its Phase 2b clinical trial of MDNA55 for the treatment of recurrent glioblastoma (“rGBM”).

 

On August 1, 2017, the Common Shares
graduated to the main board of the TSX, the premier stock exchange in Canada.

 

On October 10, 2017, new clinical
data were presented by John H. Sampson, MD, PhD, Robert H. and Gloria Wilkins Distinguished Professor and Chair of Neurosurgery
at Duke University at the 2017 Congress of Neurological Surgeons (“CNS”) (Boston, MA), demonstrating successful delivery
in brain cancer patients and a reassuring safety profile for MDNA55 as well as a substantially higher proportion of the target
tissue being covered then in previous similar trials. In some cases, close to 100% of the tumor and the 1 cm margin around it (at
risk for tumor spread) had been successfully covered.

 

On October 18, 2017, the Common Shares
were quoted for trading on the OTC marketplace under the symbol "MDNAF".

 

In November 2017, further drug distribution
and safety data were presented by Dr. Krystof Bankiewicz, MD, PhD, Kinetics Foundation
Chair in Translational Research and Professor in Residence of Neurological Surgery at the University of California San Francisco,
at the Annual Meeting of the Society for Neuro-Oncology (“SNO”) (San Francisco, CA), on the first 15 patients in the
study confirming earlier results presented at the CNS.

 

In October 2017, Medicenna was issued
a U.S. Patent related to our Superkine platform. U.S. Patent 9,738,696, issued to Leland Stanford Junior University (“Stanford”)
and licensed exclusively to Medicenna, covers the composition of engineered IL-4 Superkines.

 

    5

     

    

 

Year ended March 31, 2019

 

On May 2, 2018, Medicenna announced
that half of the patients in the ongoing Phase 2b study of MDNA55 in rGBM had been recruited and the data demonstrated solid safety
results and early signals of efficacy based on the findings of the Safety Review and Clinical Advisory Committees, comprised of
key opinion leaders and study investigators. Following the recruitment milestone, the protocol was amended to implement optimal
methodologies for treatment of the remaining patients.

 

On August 2, 2018, Medicenna announced
preliminary preclinical data on MDNA109, the only interleukin-2 (“IL-2”) in development with high affinity to the CD122
receptor to boost cancer fighting T cells, showing that fusions of MDNA109 with inactive protein scaffolds are long-acting and
provide the convenience of easier dosing without sacrificing its safety and efficacy.

 

On August 10, 2018, Medicenna received
US$1,219,871 from the Cancer Prevention and Research Institute of Texas (“CPRIT”) for the reimbursement of previously
incurred expenses.

 

On October 22, 2018, the Company presented
results and participated in a poster discussion session at the European Society for Medical Oncology (“ESMO”) Congress
held in Munich. Based on interim data from patients treated at low doses implemented during the first half of the Phase 2b
study of MDNA55, the presentation highlighted the benefits of using advanced imaging modalities in order to help tumor response
evaluation and identify pseudo-progression in some patients which ultimately translates into tumor shrinkage, and potential treatment
benefit.

 

On October 31, 2018, Medicenna provided
an interim update from the ongoing Phase 2b clinical trial of MDNA55 for the treatment of rGBM. These results were superseded by
data reported at subsequent dates.

 

On December 5, 2018, Medicenna received
a US$1.2 million reimbursement of past expenses from CPRIT.

 

On December 21, 2018, the Company
closed a short-form prospectus offering of 4,000,000 units for gross proceeds of $4,000,000. Each such unit was issued at a price
of $1.00 per unit and consisted of one Common Share and one-half common share purchase warrant of the Company. Each whole warrant
entitles the holder to purchase one Common Share at an exercise price of $1.20 until December 21, 2023. In addition, 280,000
broker warrants, allowing holders to acquire one Common Share at an exercise price of $1.20 until December 21, 2020, were
issued pursuant to the offering.

 

On February 6, 2019, Dr. Moutih
Rafei, PhD (Associate Professor, Department of Pharmacology and Physiology, Université de Montréal), presented
new results on MDNA109 and its long acting variants. The presentation outlined that MDNA109 (a) is an engineered IL-2 Superkine
exhibiting 1000-fold enhanced affinity toward the CD122 receptor, (b) has best-in-class potency toward cancer killing effector
T cells, (c) was not immunogenic in-vivo and (d) potently synergized with anti-PD-1 or anti-CTLA-4 checkpoint inhibitors
to eliminate tumors in the majority of tumor-bearing mice.

 

On February 7, 2019 Medicenna presented
new clinical study results in a podium presentation entitled “The IL4 Receptor as a Biomarker and Immunotherapeutic Target
for Glioblastoma: Preliminary Evidence with MDNA55, a Locally Administered IL-4 Guided Toxin”, by John H. Sampson, MD, PhD,
Robert H. and Gloria Wilkins Distinguished Professor and Chair of Neurosurgery at Duke University, during the 5th Annual
Immuno-Oncology 360o Conference held in New York, NY. These data were subsequently updated as described below.

 

    6

     

    

 

Year ended March 31, 2020

 

On April 30, 2019, the Company announced
completion of enrolment in the MDNA55 Phase 2b clinical study for the treatment of rGBM.

 

On May 1, 2019, Medicenna received
US$757,940 from CPRIT for reimbursement of past expenses.

 

On June 3, 2019, a poster entitled
 “MDNA55: A Locally Administered IL4 Guided Toxin as a Targeted Treatment for Recurrent Glioblastoma” was presented
at the 55th Annual Meeting of the American Society of Clinical Oncology (“ASCO”) held in Chicago, IL. The presentation
by Dr. Dina Randazzo, of Duke University School of Medicine and a Principal Investigator, focused on the development of a
new biomarker test for the interleukin-4 receptor (“IL4R”) that may enable better selection and superior treatment
outcomes for patients with rGBM.

 

On June 18, 2019, Dr. Fahar Merchant
presented results from the Phase 2b MDNA55 clinical trial for rGBM at the Inaugural Immuno-Oncology Pharma Congress in Boston,
MA. The presentation highlighted disease control in up to 83% of the patients, according to immunotherapy Response Assessment in
Neuro-Oncology (“iRANO”) criteria, which measure tumor response relative to the largest tumor size post-treatment (nadir).
In addition, safety data from the Phase 2b clinical trial showed a similar safety profile to previous MDNA55 trials, with
no systemic toxicities, no clinically significant laboratory abnormalities and no drug-related deaths.

 

On June 20, 2019, Medicenna presented
a poster entitled “Engineering a long-acting CD122 biased IL-2 superkine displaying potent anti-tumoral responses”.
The presentation by Dr. Moutih Rafei, Associate Professor, Department of Pharmacology and Physiology, Université de
Montréal, highlighted that MDNA109-LA (a precursor of MDNA19) when combined with checkpoint inhibitors (a) demonstrated
durable tumor control with strong memory response; (b) enhancing activation of naive CD8 T cells and natural killer (“NK”)
cells (responsible for attacking tumor cells) and (c) attained long term tumor control with fewer treatment cycles and a less
frequent dosing regimen.

 

On June 26, 2019, the Company reported
preclinical data on MDNA55 which showed promising results in ovarian cancer models.

 

On July 9, 2019, Medicenna announced
the receipt of US$1,915,372 from CPRIT reimbursement of past expenses.

 

On
July 31, 2019, the Company announced the selection of MDNA19 (formerly, MDNA109-LA1) as our second immuno-oncology clinical
candidate for the treatment of cancer. MDNA19 is a best-in-class long-acting IL-2 developed from our Superkine platform that has
shown unique ability to selectively stimulate cancer killing immune cells without the limitations seen with other long-acting IL-2
programs.

 

On September 24, 2019, Medicenna announced
the appointment of Ms. Karen Dawes to our Board of Directors. Ms. Dawes is an experienced and highly regarded leader
in the life sciences industry with extensive strategic expertise and considerable commercial background.

 

    7

     

    

 

On September 25,
2019, the Company presented updated efficacy results from the Phase 2b clinical trial (MDNA55-05) in the first 33 rGBM
patients enrolled in the study. MDNA55 is a potent immunotherapy agent, as it potently targets the IL4R, which is overexpressed
in glioblastoma (“GBM”), as well as non-cancerous cells that make up the brain tumor microenvironment (“TME”).
The data imply that targeting the TME, particularly in GBM, is critical where almost half of the tumor mass is made up of the TME
 – a cancer swamp that hides the tumor from the immune system. The TME is emerging as one of the key reasons why glioblastoma
is extremely aggressive, and continues to be one of the most difficult cancers to treat. Since MDNA55 can simultaneously kill both
the tumor cells and the TME by targeting the IL4R, the results to date indicate that MDNA55 could emerge as a new treatment for
this deadly disease.

 

On September 26,
2019, Medicenna announced the publication of a peer-reviewed article in the August 2019 edition of Nature Communications, providing
independent third-party validation of Medicenna’s IL-2 Superkine platform, MDNA109.

 

On September 30, 2019, the Company
announced the presentation of new preclinical data from its IL-2 Superkine program to support the differentiating characteristics
of long-acting MDNA109 variants and their potency in vitro and in vivo from other long-acting IL-2 programs.

 

On October 17, 2019, Medicenna completed
a public offering raising total gross proceeds of $6,900,000. The Company issued 5,307,693 units at a price of $1.30, each such
unit consisting of one Common Share and one-half common share purchase warrant. Each such whole warrant is exercisable at a price
of $1.75 until October 17, 2022.

 

On November 21, 2019, the Company
announced new positive results on drug distribution from the Phase 2b clinical trial of MDNA55. Implementing new advances in convection-enhanced
delivery ("CED"), that were previously not available allows us to bypass the blood-brain barrier and deliver high concentrations
of MDNA55 directly to the tumor and the at-risk area immediately surrounding it, without exposure to the rest of the body. Delivering
MDNA55 to where it needs to be, along with the ability to continuously monitor distribution using real-time imaging, allows us
to dramatically improve drug delivery and maximize tumor coverage.

 

On November 25,
2019, Medicenna announced the presentation of updated clinical results from the Phase 2b trial of MDNA55, by Dr. John
Sampson at the 24th SNO annual meeting. Dr. Sampson discussed updated efficacy results from the Phase 2b clinical
trial of MDNA55 in rGBM patients using the IL4R as an immunotherapy target.

 

On
December 12, 2019, Medicenna announced a presentation by Dr. Fahar Merchant at the Inaugural Glioblastoma Drug Development
Annual Summit. The presentation reported subgroup analysis from the first 40 patients treated with MDNA55 in a Phase 2b clinical
trial for patients with rGBM.

 

On January 8, 2020, the Company announced
receipt of $1.3 million in proceeds from the exercise of previously issued warrants.

 

On January 13,
2020, Medicenna announced results from a retrospective study of subjects with rGBM who matched eligibility requirements of subjects
enrolled in the MDNA55-05 clinical trial (Synthetic Control Arm, “SCA”) receiving standard therapies and compared their
survival versus subjects treated with MDNA55, in the Phase 2b rGBM clinical. The SCA comprised 81 rGBM patients
receiving standard therapies including Avastin®, lomustine and temozolomide (“TMZ”) with similar baseline
features as patients treated in the MDNA55 trial such as age, tumor size, ineligibility for surgery, lack of isocitrate dehydrogenase
(“IDH”) mutations, IL4R expression and other parameters known to affect survival. When comparing IL4R High groups
across the two populations, a 150% survival advantage is seen in patients who received MDNA55.

 

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On
March 17, 2020, the Company closed a public offering of 11,290,323 Common Shares at a price of $3.10 per share
for gross proceeds of approximately $35 million.

 

On March 25,
2020, Medicenna presented preclinical data, including non-human primate (“NHP”) data from its IL-2 Superkine program,
highlighting data from the long-acting variant MDNA19, engineered to have enhanced binding to CD122 without binding to CD25. This
allows MDNA19 to specifically activate naive CD8 T cells and NK cells with minimal stimulation of regulatory T cells (“Tregs”),
thereby circumventing toxicity and demonstrating potential for best-in-class features which was supported by the NHP data.

 

In March 2020, the World Health Organization
declared the COVID-19 outbreak a global pandemic. We continue to monitor the COVID-19 situation, which is rapidly developing. The
Company operates in a virtual manner and current operations have not been impacted in any material way by the health crisis. However,
the pandemic does have an impact on our third party vendors which could result in the interruption of operations and result in
development delays including the timing of the End of Phase 2 clinical study meeting for MDNA55 with the US FDA, the ongoing pre-clinical
and future clinical activities related to MDNA19 or MDNA11. We have required all of our employees to work from home and are asking
business partners to engage us by telephone or video conference where possible, eliminating business travel and requiring self-isolation
for employees travelling outside of Canada. As the COVID-19 health crisis further develops, we will continue to rely on guidance
and recommendations from local health authorities, Health Canada and the Centers for Disease Control and Prevention to update our
policies.

 

Subsequent Events

 

On April 15, 2020, Medicenna announced
the closing of the full over-allotment option to purchase an additional 1,693,548 Common Shares of Medicenna at a price of $3.10 per
share, in connection with the public offering of Common Shares of Medicenna that was completed on March 17, 2020.

 

On May 4, 2020, Medicenna announced
that it will be presenting two abstracts at the American Society of Clinical Oncology Virtual Scientific Program to be held from May 29
to May 31, 2020. The first abstract has been selected for a poster discussion and will provide new data on tumor response
as well as survival outcomes compared to a matched SCA. The second abstract will present
preclinical data including non-human primate data for MDNA11, one of Medicenna's IL2 Superkine candidates.

 

Significant Acquisitions

 

Except as set forth herein, the Company
has not completed any significant acquisitions for which disclosure would be required under Part 8 of National Instrument
51-102 as at the date hereof.

 

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narrative
description of the Business

 

Overview

 

Medicenna is a clinical stage immuno-oncology
company developing novel, highly selective versions of IL-2, interleukin-4 (“IL-4”) and interleukin-13 (“IL-13”)
tunable cytokines, called “Superkines”. These Superkines can be developed either on their own as short or long-acting
therapeutics or fused with cell killing proteins in order to generate Empowered CytokinesTM (“ECs”) that precisely
deliver potent toxins to the cancer cells without harming adjacent healthy cells. Medicenna’s mission is to become the leader
in the development and commercialization of targeted ECs and Superkines for the treatment of a broad range of cancers. The Company
seeks to achieve its goals by drawing on its expertise, and that of world-class collaborators, in order to develop a unique set
of therapeutic Superkines. Compared to naturally occurring cytokines – that bind to multiple receptor types on many cell
types – Superkines are engineered with unique specificity toward defined target cell subsets to enable precise activation
or inhibition of relevant immune cells in order to improve therapeutic efficacy and safety. Superkines can also be fused with other
types of proteins such as antibodies to generate novel “immunocytokines” or combined with other treatment modalities
such as checkpoint inhibitors, chimeric antigen receptor T cells (“CAR-Ts”) or oncolytic viruses to stimulate tumor-killing
immune cells or overcome the immunosuppressive tumor microenvironment.

 

Medicenna has completed enrolment in a
Phase 2b clinical trial of MDNA55, Medicenna’s lead EC, for the treatment of rGBM, the most common and uniformly fatal form
of brain cancer. MDNA55 is a fusion of a circularly permuted version of IL-4, fused to a potent fragment of the bacterial toxin
Pseudomonas exotoxin (“PE”), that is designed to preferentially target tumor cells that over-express the IL4R. MDNA55
has now been studied in 5 clinical trials in 132 patients, including 112 patients with rGBM, in which it has shown indications
of superior efficacy when compared to the current standard of care (“SOC”). MDNA55 has secured Orphan Drug Status from
the United States Food and Drug Administration (“FDA”) and the European Medicines Agency (“EMA”) as well
as Fast Track Designation from the FDA for the treatment of rGBM and other types of high grade glioma. Medicenna announced on April 30,
2019 that patient enrollment was complete in the Phase 2b clinical trial of MDNA55 after treating 46 patients with rGBM. Medicenna
announced preliminary top line data from the study on June 18, 2019 and additional survival data in December 2019 and
January 2020. Medicenna plans to have an End of Phase 2 (“EOP2”) meeting with the FDA in 2020. This timeline
is later than previously disclosed as additional time was required to collect further data to be included in the submission package
as recommended by the Company’s regulatory advisors in order to strengthen the submission.

 

Complementing Medicenna’s lead clinical
asset (MDNA55), the Company has built a deep pipeline of promising preclinical Superkine candidates such as IL-2 agonists (MDNA109), IL-2
antagonists (MDNA209), dual IL-4/IL-13 antagonists (MDNA413) and IL-13 Superkine (MDNA132) all in-licensed from Stanford. The most
advanced of these programs is the MDNA109 platform, which is in preclinical development and is the only engineered IL-2 Superkine
designed to specifically target CD122 (IL-2Rβ) with high affinity without CD25 dependency. The lead candidates from the IL-2
Superkine platform are MDNA19 and MDNA11 (formerly known as MDNA109-LA1) which, unlike native IL-2 (Proleukin) have superior pharmacokinetic
(“PK”) properties, lack CD25 binding in order to improve safety, potently stimulate effector T cells, reverse NK cell
anergy and act with exceptional synergy when combined with checkpoint inhibitors. Medicenna is working towards initiating a Phase
1 clinical study for MDNA19 or MDNA11 mid-2021.

 

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Our Product Candidates

 

 

MDNA55

 

MDNA55 is a novel, locally acting, anti-cancer
therapeutic being developed by Medicenna for the treatment of tumors of the brain in adults, of which GBM is the most aggressive
type. GBM is also the most common form of adult brain cancer, with 27,500 new cases diagnosed each year and the second most common
cause of brain cancer deaths. MDNA55 has obtained Fast Track Designation from the FDA as well as Orphan Drug Designation from the
FDA and the EMA.

 

MDNA55: Structure and Mechanism of Action

 

MDNA55 is a targeted fusion protein being
developed by Medicenna for the treatment of tumors that over-express the IL4R. MDNA55 (below) consists of a high-affinity circularly
permuted variant of IL-4 (cpIL-4) fused with a truncated version of PE.

 

 

MDNA55 binds with high affinity to IL-4R
overexpressed on the surface of tumor cells and is endocytosed. Following cleavage and activation by furin-like proteases found
in the endosome of cancer cells, the catalytic domain of the truncated PE is released into the cytosol where it induces cell death
via ADP-ribosylation of elongation factor-2 (below).

 

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Expression levels of IL4R are low on the
surface of healthy and normal cells, but increase 10- to 100-fold on cancer cells. This differential expression of IL4R therefore
provides MDNA55 a wide therapeutic window.

 

The IL4R is an ideal target for the development
of cancer therapeutics, as it is frequently and intensely expressed on a wide variety of human carcinomas. However, the IL4R target
is currently under-exploited. Analysis of over 2,000 biopsies show IL4R over-expression in 20 different cancers affecting over
a million cancer patients every year. Furthermore, the IL-4/IL4R bias is a marker for highly aggressive forms of cancer, plays
a central role in the establishment of an immunosuppressive TME and is generally associated with poor survival outcomes. By disrupting
this pro-tumoral IL-4/IL4R axis, MDNA55 directly interferes with multiple networks that support cancer.

 

Glioblastoma

 

GBM is an aggressive brain tumor characterized
by rapid proliferation of undifferentiated cells, extensive infiltration, and a high propensity to recur. It is a rapidly progressing
and universally fatal cancer. First-line treatment for primary GBM generally includes surgical resection of the bulk tumor to the
maximal extent possible, followed by radiotherapy, often in combination with chemotherapy consisting of TMZ. The approval of TMZ
represented a breakthrough in treatment; the drug offers improvements in overall survival (“OS”), although the actual
benefits are modest. When used in combination with radiotherapy following surgery, TMZ provided a median survival of 58.4 weeks
for newly diagnosed GBM patients compared to 48.4 weeks for radiotherapy alone. TMZ is less effective in GBM patients who harbor
unmethylated O6-methylguanine-methyltransferase (“MGMT”) promoters in the tumor tissue; more than half of GBM patients
have unmethylated MGMT promoters. In practice, even patients without MGMT promoter methylation are prescribed TMZ because of a
lack of approved treatment alternatives.

 

Recurrent Glioblastoma (rGBM)

 

Unlike treatment of newly diagnosed GBM,
no consensus exists regarding the optimal treatment of rGBM. Recurrence rates for newly diagnosed GBM patients treated with the
current SOC is high, even in completely resected patients.

 

    12

     

    

 

 

Drugs currently approved in the United
States for treatment of rGBM are Gliadel® and bevacizumab (Avastin®). In a Phase 3 study, placing a Gliadel
implant directly into the tumor cavity after surgical resection of the tumor, 56% of rGBM treated subjects survived 6 months and
the median survival was 26 weeks. However, the majority of patients with rGBM are not candidates for additional surgery, resulting
in a large unmet need for this patient population.

 

Avastin® is an anti-angiogenic
antibody that targets the vascular endothelial growth factor receptors. It is indicated as a single agent for adult patients with
rGBM but has not been shown to improve disease-related symptoms or survival. Avastin® was granted accelerated approval
on the basis of an objective response rate (“ORR”) of 28% following an open label Phase 2 study in 85 patients receiving
Avastin® only. In 2013, Avastin® completed its confirmatory trial in newly diagnosed GBM patients
and did not meet its primary endpoint of overall survival. Based on the results of this trial, Genentech, for Avastin®,
did not receive approval in the European Union for newly diagnosed GBM; however, Avastin® remains indicated in the
United States and Japan for rGBM.

 

Rationale for Development of MDNA55 for rGBM

 

MDNA55 is being initially developed for
the treatment of rGBM. Using current treatment paradigms, most GBM patients experience tumor recurrence/progression after standard
first line treatment. Treatment options for patients with rGBM are very limited and the outcome is generally unsatisfactory. Specifically,
chemotherapy regimens for recurrent or progressive GBM have been unsuccessful, producing toxicity without benefit. As overall survival
remains dismal, novel anti-cancer modalities, with greater tumor specificity, more robust cytotoxic mechanisms and novel delivery
techniques are needed for the treatment of recurrent GBM.

 

MDNA55 is one such novel therapeutic that
provides a targeted treatment approach whereby tumor cells are more sensitive to the toxic effects of the drug than normal cells.
When combined with a novel precision delivery to the brain using CED, treatment with MDNA55 could be an ideal approach for the
treatment of rGBM and other brain tumors that over-express the IL4R. Cells that do not express the IL4R target do not bind to MDNA55
and are, therefore, not subject to the effects of the toxic payload.

 

Many features of MDNA55 make it a potentially
attractive choice for the treatment of recurrent GBM:

 

		1.	The majority of cancer biopsy and autopsy samples from adult and pediatric primary and metastatic
brain cancers, including rGBM, have been shown to over-express the IL4R with little or no IL4R expression in normal adult and pediatric
brain tissue.

 

		2.	MGMT positive cancer cells (harboring unmethylated MGMT promoters) are common in GBM, making them
resistant to TMZ. However, MGMT positive cancer tumors are extremely sensitive to MDNA55, suggesting that MDNA55 could provide
a treatment option for GBM patients who would not benefit from TMZ.

 

		3.	GBM has a robust immunosuppressive TME and may comprise up to 40% of the tumor mass. It has been
shown that malignant gliomas have a T-helper cell type-2 (“Th2”) bias and are heavily infiltrated by myeloid derived
suppressor cells (“MDSCs”) and tumor associated macrophages (“TAMs”) and that the IL-4/IL4R bias mediates
their immunosuppressive functions. Furthermore, IL4R is up-regulated on glioma-infiltrating myeloid cells but not in the periphery
or in normal brain. Thus, purging Th2 cells, MDSCs, and TAMs using MDNA55 may alleviate the immune block associated with cancer
(in a manner similar to immunomodulators such as ipilumimab, pembrolizumab or nivolumab), thereby promoting anti-tumor immunity
and aid in long-term disease control.

 

    	 	 	13

     

    

 

The MDNA55 program therefore offers a promising
approach to address serious unmet needs for brain cancer patients. Furthermore, MDNA55 is the only treatment in development that
has the potential to simultaneously target the bulk tumor and the immunosuppressive TME. Accordingly, we are of the view that MDNA55
has the potential of altering the treatment paradigm for many brain cancer patients.

 

Convection Enhanced Delivery of MDNA55

 

As with most protein therapeutics, MDNA55
does not cross the blood-brain barrier, and therefore must be delivered directly to the tumor (also known as intra-tumoral therapy)
via local one time infusion procedure called CED. Medicenna’s development platform includes rights to all oncology indications
for MDNA55 as well as novel image guided CED of MDNA55. These technologies are protected by patents either owned or exclusively
licensed by Medicenna.

 

Development History of MDNA55

 

The targeting domain and payload for Medicenna’s
lead candidate, MDNA55, were developed in the laboratories of Dr. Ira Pastan at the National Cancer Institute (NCI) and Dr. Raj
Puri at Center for Biologics Evaluation and Research, at the FDA. The targeting domain (IL-4) was engineered to improve the binding
affinity of IL-4 to the IL4R and thereby increase potency of MDNA55. The payload domain (pseudomonas toxin) of MDNA55 was engineered
in order to remove off-target binding components further improving safety. Preclinical and clinical development of MDNA55 for the
treatment of brain as well as other non-brain tumors is described in over 50 publications.

 

In March 2013, Medicenna acquired
all clinical, regulatory and material assets for MDNA55 from Sophiris Bio Inc. (formerly Protox Therapeutics, Inc.) (“Sophiris”).
The acquisition was comprised of two Investigational New Drug Applications (“IND”) with the FDA, Fast Track Designation
from the FDA, Orphan Drug Designations from the FDA and the EMA, clinical data from 72 patients enrolled in three different brain
cancer studies, clinical data from 14 patients enrolled in a Phase 1 solid tumor study and all cell banks and reference material
required to manufacture MDNA55. Subsequent to the purchase agreement with Sophiris, Medicenna and the National Institutes of Health
(“NIH”) entered into license agreements (the “NIH License Agreements”) covering composition, methods
of use, combination therapy and delivery of MDNA55. A summary of the clinical trials related to the treatment of high grade gliomas
is provided below.

 

Three clinical trials were previously conducted
with MDNA55 in 72 patients with recurrent high grade glioma (66 rGBM and 6 recurrent anaplastic astrocytoma (“rAA”)
patients). In a majority of the patients, MDNA55 was delivered only once by intratumoral infusion using CED via ventricular catheters.

 

A Phase 1 single centre investigator initiated
study (United States) was conducted in a single United States site enrolling nine subjects with rGBM. Doses evaluated ranged from
0.2 to 6.0 μg/mL (total dose 6 to 720 μg). One subject remained disease free at >18 months after the procedure;
6 out of 8 subjects had partial to extensive tumor necrosis confirmed by pathology. Most subjects had transient increased intracranial
pressure treated readily with craniotomy.

 

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A Phase 1 sponsor initiated multi-centre
study (Germany and United States) was carried out in 31 subjects of whom 25 subjects had rGBM and six subjects had rAA. Treatment
with MDNA55 using intratumoral CED infusion was dose escalated from 240 to 900 μg. In approximately 40% of the subjects, anti-MDNA55
antibodies were observed. Systemic toxicity was not observed. Although not designed to measure efficacy, results showed MDNA55
administration was followed by rapid tumor necrosis with an ORR (i.e. ≥50% decrease in tumor size) of 56%. These data compare
favourably with an ORR of 5% with current therapies and ORR of 28% achieved by Avastin®. These results, including
a complete response rate (100% decrease in tumor size) of 20% following a single treatment with MDNA55 were encouraging given that
nearly half of the subjects enrolled in the trial had multiple relapses and had poor prognosis due to late stage of the disease.
Furthermore, catheter placement and CED of MDNA55 were not optimized at that time.

 

In the Phase 2a multi-centre study (United
States and Germany), MDNA55 was administered by intratumoral infusion via CED in 32 subjects with rGBM at doses of 90 μg,
240 μg or 300 μg. Approximately 3 weeks post-infusion, surgical resection was performed and therefore tumor response
analysis was not performed. Tissue samples pre- and post-treatment were adequate for assessment in 10 to 32 subjects. Seven subjects
showed a marked reduction in tumor cellularity post-treatment. Of these seven cases, five showed little or no cellular tumor in
the resection samples, while the other two had at least a 75% reduction of cellular tumor. The remaining three subjects showed
no change compared to baseline. These results, although preliminary, were consistent with ORR observed in the earlier studies.
As in the previous studies, systemic toxicity was not observed.

 

Improvements in CED Technology for MDNA55

 

Since the above mentioned clinical trials,
there have been many improvements to the CED technology. This includes use of newly developed techniques for high precision placement
of catheters into the tumor bed as well as novel stepped design catheters that prevent backflow of MDNA55 during treatment. Furthermore,
by co-infusion of an MRI contrast agent with MDNA55, drug distribution can be monitored in real-time ensuring complete coverage
of the tumor bed and the tumor margins. Unlike previous clinical trials, each of these improvements has facilitated highly accurate
targeting and uniform distribution of MDNA55 to regions of active tumor growth in the current clinical trial.

 

 

 

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Medicenna has obtained an exclusive license
from the NIH to patents covering CED and the use of a surrogate tracer for real-time monitoring of MDNA55 delivery and distribution.

 

Phase 2b Study Outline for Glioblastoma
at First Recurrence or Progression

 

The Phase 2b trial with MDNA55 using enhanced
CED delivery is a multi-center, open-label, single-arm study in up to 52 patients (at least 46 intent-to-treat (“ITT”)
patients evaluable for survival and 35 patients evaluable for response), with first or second recurrence or progression of GBM
after surgery or radiotherapy ± adjuvant therapy or other experimental therapies.

 

The primary endpoint of the study is median
overall survival (mOS) comparing an expected null survival rate of 8.0 months (based on historical control) with an alternative
pursue rate of 11.5 months (1-sided alpha = 0.10 and 80% power for approximately 46 ITT or per protocol subjects). The secondary
endpoint is objective response rate (ORR) assessed by the modified Response Assessment in Neuro-Oncology (mRANO)-based criteria
incorporating advanced imaging modalities according to a null response rate of 6% with an alternative pursue rate of 18% (1-sided
alpha = 0.10 and 80% power for at least 35 subjects evaluable for response). IL4R expression levels in tumor biopsies and their
potential impact on patient outcomes following treatment with MDNA55, were retrospectively evaluated.

 

Phase 2b Study Update

 

In April 2017, we treated the first
rGBM patient in the Phase 2b clinical trial of MDNA55 and enrolled patients at eight clinical sites across the United States with
enrolment in the study (46 ITT patients) completed in April 2019.

 

While the Company previously targeted completion
of the Phase 2b by not later than Q4 2018, the protocol amendments announced in September 2017 and May 2018, and described
below, resulted in slower than anticipated patient recruitment.

 

On September 28, 2017, we announced
that based on encouraging drug distribution and safety data observed we implemented an amended protocol incorporating enhanced
drug delivery procedure which was used for the treatment of the remaining patients. The amended protocol allowed higher doses and
volumes of MDNA55 as well as an increase in the total expected study size – from 43 patients under the original protocol
to up to 52 total planned patients. This protocol amendment was based on a planned safety analysis following a unanimous recommendation
from MDNA55’s Safety Review Committee. Of the up to 52 patients to be treated in the study we required at least 46 of those
patients to be evaluable for survival and at least 35 subjects evaluable for response. We met our threshold enrolment requirements
in April 2019 with 46 patients treated (ITT population) of which 44 patients met all the protocol eligibility requirements
(per protocol population).

 

On October 10,
2017, clinical data were presented by Principal investigator John H. Sampson MD, PhD, (Robert H. and Gloria Wilkins Distinguished
Professor and Chair of Neurosurgery at Duke University in Durham, NC) at the 2017 CNS (Boston, MA), demonstrating successful delivery
of MDNA55 in rGBM patients and a reassuring safety profile. Furthermore, the data showed that a substantially higher proportion
of the target tissue was being covered then in previous similar trials. In some cases, close to 100% of the tumor and the 1cm margin
around it (at risk for tumor spread) had been successfully covered.

 

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Additional clinical
data from the Phase 2b rGBM clinical trial of MDNA55 were presented at the 22nd Annual Meeting of the SNO held in San
Francisco in November 2017. Dr. Krystof Bankiewicz, MD, PhD, Professor in Residence of Neurological Surgery at the University
of California San Francisco, provided an update on drug distribution and safety data from the first 15 patients treated in the
study. The oral and poster presentations at the SNO conference outlined that through a process of real-time image guided delivery
together with the ability to monitor and adjust infusion parameters, drug delivery was dramatically improved with significant enhancement
in target coverage. A previous CED study in rGBM, without the advances implemented by Medicenna, [ref: J Neurosurg. 2010 Aug;113(2):301-9],
was able to achieve, on average, coverage of only 20% of the target volume. In contrast, in the current study, a comparable estimate
for coverage of the tumor and a 1 cm high-risk margin around it showed approximately 65% coverage with the figure rising to
75% for the tumor area alone, with some patients achieving near 100% coverage of the target volume.

 

It was reported on May 2, 2018 that
half the patients in the study had been recruited and the data to date demonstrated solid safety results and early signals of efficacy
based on the findings of the Safety Review and Clinical Advisory Committees, comprised of key opinion leaders and study investigators.
Following the Safety Review, Medicenna amended the protocol at the recommendation of clinical advisors to further improve the chances
for demonstrating increased therapeutic benefit for patients. The amendment allowed the implementation of optimal methodologies
including more personalized dosing based on the tumor load, incorporation of advanced imaging modalities to measure treatment responses
more reliably, use of sub-therapeutics dose of Avastin® in patients that could not tolerate steroid use to control
edema and inflammation and allowing investigators to administer a second dose of MDNA55 where appropriate.

 

Review of some patients who had been withdrawn
from the study, believing that their disease had progressed, found that the apparent increases in tumor volumes, seen on brain
scans, were, in fact, due to tissue necrosis, inflammation and edema. This is a known effect of immunotherapeutic agents such as
MDNA55, called pseudo-progression, which poses a challenge to patient retention, management and data interpretation. When evaluating
images from such patients, using multi-modal imaging, Medicenna found evidence of biological activity of MDNA55 suggesting that
these patients were benefiting from the treatment, and in multiple cases following withdrawal from the study, surgical resection
showed significant tumor necrosis. This amendment allowed a biopsy and/or advanced multi-modal imaging to more accurately discriminate
between necrosis/inflammation and true disease progression. These tools would encourage subjects to remain in the study, where
appropriate, giving time for the pseudo-progression to resolve and increase the likelihood of clinical responses.

 

Following
the amended protocol as announced on May 2, 2018 and after receiving the necessary regulatory and site approvals patient enrolment
was resumed at higher doses provided that the pre-established maximum tolerated dose (MTD) of 240 mg
was not to be exceeded.

 

The protocol amendments announced September 28,
2017 and May 2, 2018 resulted in increased timelines for completion of the MDNA55 Phase 2b clinical trial due to an increase
in the original number of patients as well as a slowdown of patient recruitment while the necessary regulatory reviews and approvals
were completed.

 

On October 22, 2018, the Company presented
results and participated in a poster discussion session at the ESMO Congress held in Munich. Based on interim data from patients
treated at low doses implemented during the first half of the Phase 2b study of MDNA55, the presentation highlighted the benefits
of using of advanced imaging modalities in order to help tumor response evaluation and identify pseudo-progression in some patients
which ultimately translates into tumor shrinkage, and potential treatment benefit.

 

    	 	 	17

     

    

 

On October 31, 2018, Medicenna provided
an interim update from the ongoing Phase 2b clinical trial of MDNA55 for the treatment of rGBM. These results were superseded by
data reported on February 7, 2019 as described below.

 

On February 7, 2019, Medicenna presented
new clinical study results in a podium presentation entitled “The IL4 Receptor as a Biomarker and Immunotherapeutic Target
for Glioblastoma: Preliminary Evidence with MDNA55, a Locally Administered IL-4 Guided Toxin”, by John H. Sampson, MD, PhD,
Robert H. and Gloria Wilkins Distinguished Professor and Chair of Neurosurgery at Duke University, during the 5th Annual
Immuno-Oncology 360o Conference held in New York, NY. These results have subsequently been superseded by more complete
data presented in late 2019 and January 2020.

 

On April 30, 2019, Medicenna announced
that enrolment in the study was complete with 46 evaluable patients (ITT population) of which 44 patients were subsequently identified
as meeting protocol eligibility requirements without major deviations (per protocol population).

 

On June 3, 2019, a poster entitled
 “MDNA55: A Locally Administered IL4 Guided Toxin as a Targeted Treatment for Recurrent Glioblastoma” was presented
at the 55th Annual Meeting of the ASCO held in Chicago, IL. The presentation by Dr. Dina Randazzo, of Duke University
School of Medicine and a Principal Investigator, focused on the development of a new biomarker test for the IL4R that may enable
better selection and superior treatment outcomes for patients with rGBM. These data were subsequently updated, as described below.

 

On June 18, 2019, Dr. Fahar Merchant
presented results from the Phase 2b MDNA55 clinical trial which recently completed enrollment (n=46) at the Inaugural Immuno-Oncology
Pharma Congress in Boston, MA. The presentation highlighted disease control in up to 83% of the patients according to iRANO criteria,
which measure tumor response relative to the largest tumor size post-treatment (nadir). Use of advanced imaging techniques (such
as perfusion and diffusion MRI) was able to show underlying tissue response amidst inflammation and edema in some subjects. In
addition, safety data from the Phase 2b clinical trial show a similar safety profile to previous MDNA55 trials, with no systemic
toxicities, no clinically significant laboratory abnormalities and no drug-related deaths.

 

On September 25,
2019, the Company presented updated efficacy results from the Phase 2b clinical trial MDNA55-05 in rGBM patients using
the IL4R as an immunotherapy target, as it is overexpressed in glioblastoma as well as in cells that make up the brain tumor microenvironment.
The data imply that targeting the TME, particularly in GBM, is critical where almost half of the tumor mass consists of non-cancerous
cells that make up the TME – a cancer swamp that hides the tumor from the immune system. The TME is emerging as one of the
key reasons why glioblastoma is extremely aggressive, and continues to be one of the most difficult cancers to treat. Since MDNA55
can simultaneously kill both the tumor cells and the TME by targeting the IL4R, the results to date continue to show that MDNA55
is likely to emerge as a new treatment for this deadly disease. These data were subsequently updated in November and December 2019
and January 2020.

 

    	 	 	18

     

    

 

On November 25,
2019, Medicenna announced the presentation of updated clinical results presented by Dr. John Sampson from our Phase 2b trial
of MDNA55 at the 24th SNO annual meeting. The presentation highlighted that with a single treatment with MDNA55,
the median overall survival (“mOS”) in IL4R High subjects (n=21) was 15 months showing a survival advantage
of up to nine months when compared to approved therapies (mOS of 5.4 to 9.2 months with temozolomide, Avastin® and
lomustine), among the 38 evaluable subjects, irrespective of IL4R expression, 82% of the subjects experienced tumor shrinkage or
stabilization from nadir. The mOS of patients showing tumor control (n=31) was significantly longer when compared to patients with
progressive disease (mOS of 15 months vs. 8.4 months, respectively; p-value of 0.0112) and updated analysis included the first
40 subjects treated with MDNA55 continuing to show an overall survival rate at 12 months (“OS-12”) of 45%, irrespective
of IL4R expression, and OS-12 of 58% in patients showing a treatment response (n=32). This is an improvement of up to 150% when
compared to approved therapies for rGBM (OS-12 is 18-34%).

 

On
December 12, 2019, the Company announced data presented by Dr. Fahar Merchant at the Inaugural Glioblastoma Drug Development
Annual Summit. The presentation reported subgroup analysis from the first 40 patients treated with MDNA55 in the Phase 2b clinical
trial. The presentation highlighted that the patient characteristics in the clinical study excluded patients that are known to
have a much better prognosis, such as patients that were, (a) eligible for surgery to remove the tumor, (b) had a lower
grade of brain cancer at initial diagnosis (only de novo GBM patients were enrolled), and (c) had a known
mutation associated with better prognosis (IDH mutation). Furthermore, the presentation emphasized that despite enrolling only
patients known to have a very poor prognosis, patients actually did much better and were surviving significantly longer following
only one treatment with MDNA55, particularly in patients with high expression of the IL4R target. Of particular interest, subjects
receiving lower doses of steroids (≤4 mg of concurrent steroid per day) showed a trend towards improved survival, particularly
in the IL4R High group, with a mOS of 16.5 months with 88% of patients being still alive at 12 months. In patients resistant to
approved chemotherapy Temodar (rGBM with unmethylated MGMT promoter), MDNA55 treatment in IL4R High patients had a median overall
survival of 15.2 months and a 12 month survival rate of 69% versus 22% for lomustine and less than 19% for Avastin®.

 

 

 

On January 13,
2020, Medicenna announced that it had completed a retrospective study on subjects with rGBM who matched eligibility requirements
of subjects enrolled in the MDNA55-05 clinical trial. The study was conducted to compare the survival of subjects treated with
MDNA55 in the Phase 2b rGBM clinical trial versus matched patients (SCA) recently treated using other standard therapies.
The SCA comprised 81 rGBM patients receiving standard therapies including Avastin®, lomustine and TMZ with similar
baseline features as patients treated in the MDNA55 trial such as age, tumor size, ineligibility for surgery, IL4R expression
and other parameters known to affect survival.

 

    	 	 	19

     

    

 

Key data from the study are summarized
below and have been computed from the date of relapse rather than from the date of treatment in results previously reported by
the Company:

 

		·	When comparing IL4R High groups across
the two populations, a 150% survival advantage is seen in patients who received MDNA55.

 

		o	IL4R High subjects treated with MDNA55 (n=21) had a mOS of 15.8 months versus 6.2 months in the
SCA (n=17), a survival advantage of an impressive 9.6 months.

 

		o	OS-12 was 62% in the MDNA55 arm versus 24% in the SCA.

 

		·	Regardless of IL4R status, subjects treated
with MDNA55 (n=44 subjects comprising the complete per protocol analysis population) demonstrated 112% increase in OS-12 over subjects
in the SCA (n=81).

 

		o	OS-12 for the MDNA55 arm was 53% versus 25% in the SCA.

 

		o	mOS in the MDNA55 arm was 12.4 versus 7.7 months in the SCA.

 

 

 

Medicenna plans to have an EOP2 meeting
with the FDA in 2020 to discuss the results of the MDNA55 Phase 2b clinical study and the development pathway forward, including
the possibility of seeking accelerated approval in patients with IL4R positivity which is considered to display a more aggressive
form of rGBM. This date is later than previously anticipated due to additional information being prepared in order to strengthen
the submission to the FDA as recommended by regulatory consultants.

 

    	 	 	20

     

    

 

The Company expects the completion of clinical
development of MDNA55 to full approval (including a pivotal Phase 3 clinical trial), if undertaken by Medicenna, to last until
at least 2022, with a projected aggregate cost of up to approximately $75 million, incremental to the current cash on hand. It
is anticipated that following the successful completion of the Phase 2b clinical trial and a successful EOP2 meeting with the FDA
the Company will work to out-license the program to one or more partners who would fund or co-fund Phase 3 clinical development
of MDNA55 as well as prepare the program for commercialization and its subsequent launch in various countries where approval has
been granted. In addition to development and regulatory approval of MDNA55, the Company and/or its partner may also have to develop
and commercialize a companion diagnostic to test for IL4R expression prior to treatment with MDNA55. See “Risk Factors”
below

 

Potential Market: MDNA55

 

The incidence of primary brain cancer in
the 7 major markets (“7MM”) (United States, UK, Japan, Italy, Spain, France and Germany) exceeded 52,000 with
over 37,000 deaths. Of the primary brain cancers, GBM is the most common, aggressive and with one of the worst prognoses of all
cancers. GBM accounts for 52% of all primary brain tumors and although treatment options include surgery, radiation and chemotherapy,
the 5-year survival rate is less than 10%. The incidence of GBM in the 7MM is expected to increase from 27,500 in 2012 to 32,000
in 2022 with therapeutic sales projected to reach US$1.4 billion by 2022.

 

Treatment options for rGBM are severely
limited. With the exception of Avastin®, providing no survival benefits, no universal SOC exists for rGBM.
Avastin® has not been approved by the EMA for newly diagnosed GBM or rGBM, although it has been granted accelerated
approval by the FDA for rGBM. Management believes that MDNA55 is currently well positioned for the rGBM indication, when used either
as monotherapy or in combination with other approved therapies. Line extension for metastatic brain cancer, newly diagnosed GBM
and pediatric gliomas has the potential to increase MDNA55 revenues.

 

MDNA55 Competition: Emerging Therapies for Adult GBM

 

The SOC for newly diagnosed GBM, consisting
of surgery, radiotherapy and concurrent TMZ followed by adjuvant TMZ has not changed for over a decade. The lack of effective treatment
options extends to a shortage of approved targeted therapies for GBM. Development of novel agents for the treatment of GBM is therefore
an active area of research, and multiple agents and drug classes are being assessed for GBM.

 

Northwest Biotherapeutics’ DCVax-L,
an autologous dendritic cell vaccine, is one of the furthest along in development for GBM. DCVax-L is being evaluated in newly
diagnosed GBM patients who have received a complete surgical resection and received radiotherapy and concurrent TMZ. Northwest
has completed a Phase 3 clinical trial in patients with newly diagnosed GBM and expects to announce top-line data in mid-2020.

 

DNAtrix’s DNX-2401, an oncolytic
immunotherapy, has completed enrolment in a Phase 2 clinical trial in collaboration with Merck which evaluated the efficacy and
safety of DNX-2401 in combination with pembrolizumab (KEYTRUDA), Merck’s anti-PD-1 therapy. Adult subjects diagnosed
with GBM or gliosarcoma that have experienced disease progression after initial treatment were candidates for the trial. Interim
data were presented in November 2019 and DNAtrix has disclosed plans to initiate a Phase 3 clinical study.

 

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Delmar Pharmaceuticals’ product VAL-083
is a “first-in-class” small molecule chemotherapeutic and is enrolling patients in a Phase 2 clinical trial of VAL-083
in patients with MGMT unmethylated, bevacizumab-naive rGBM. The study is expected to be completed in 2020.

 

Ziopharm Oncology has a controlled IL-12
platform, or Ad-RTS-hIL-12 plus veledimex (Ad+V), which completed a Phase 1 clinical studies in both a monotherapy and in combination
with a PD-1 inhibitor, for the treatment of recurrent or progressive glioblastoma multiforme in adults in 2019 and subsequently
announced the initiation of a Phase 2 clinical trial in mid-2019. Interim data related to the Phase 1 clinical trials were released
in November 2019.

 

Istari Oncology is enrolling patients in
a Phase 2 multi-institutional, dose refinement trial that includes a chemotherapy component found to be beneficial in the Phase
1 study. The trial is testing PVSRIPO which is an oncolytic poliovirus delivered by way of intratumoral administration for the
treatment of rGBM. The clinical trial involves 62 GBM patients and should be completed in 2020. In addition, Istari is evaluating
D2C7-IT, an antibody-directed immune conjugate, in a dose escalation Phase 1 study in 24 recurrent GBM patients.

 

In mid-stage development, Agenus is developing
a heat shock protein (gp96) peptide complex (HSPPC-96), an intradermal, autologous, cancer vaccine. Designated as the Prophage
G series, Prophage G-100 is applied in newly diagnosed GBM patients and G-200, in rGBM. Phase 2 results for the Prophage G series
vaccines demonstrate that the agent may hold promise in a very select group of patients.

 

Diffusion Pharmaceuticals has a small molecule
that enhances oxygen delivery to hypoxic tissues (Trans sodium crocetinate, “TSC”). Since GBM is a highly hypoxic tumor,
increased oxygenation is thought to enhance standard of care chemoradiation therapy. TSC is currently being investigated in a Phase
3 clinical trial in patients in newly diagnosed GBM.

 

Superkines

 

Developed by scientists at Stanford, Medicenna
has exclusively licensed an impressive library of tunable cytokines, which we call Superkines. These cytokines include IL-2, IL-4
and IL-13, which are known to be engaged in modulating nearly 2,000 different types of human ailments.

 

Our Superkines have been engineered to
bind to different receptor sub-types with variable specificity and affinity with the additional capacity to tune signaling pathways,
cellular responses and cell fate. Further, by fusing Superkines to payloads, antibodies or inactive protein scaffolds, Medicenna
is able to generate ECs, immunocytokines and long-acting Superkines, respectively, providing additional functionality, targeted
delivery and improved pharmacokinetics. Superkines can also be combined with other immunotherapies such as CAR-T cells, checkpoint
inhibitors and oncolytic viruses to provide a cytokine boost by stimulating tumor-killing immune cells or inhibiting immunosuppressive
cells of the tumor microenvironment.

 

    	 	 	22

     

    

 

 

 

IL-2 Superkines

 

IL-2 was one of the first effective immunotherapies
developed to treat cancer due to its proficiency at expanding T cells, the central players in cell-mediated immunity. Originally
discovered as a growth factor for T cells, IL-2 can also drive the generation of activated immune cells, immune memory cells,
and immune tolerance.

 

In contrast, IL-2 induced overstimulation
of immune cells can lead to an imbalance in the ratio of effector and regulatory T cells, resulting in autoimmune diseases.

 

Part of the reason for this is due
to the nature of the IL-2 receptor. The IL-2 receptor is composed of three different subunits, IL-2Rα (also known as
CD25), IL-2Rβ (CD122) and IL-2Rγ (CD132). The arrangement of these different proteins determines the response to
IL-2 signaling.

 

The IL-2β and IL-2γ components
together make a receptor capable of binding IL-2, but only moderately so. When all three components are together, including IL-2Rα,
the receptor binds IL-2 with a much higher affinity. This complete receptor is usually found on regulatory T cells, which dampens
an ongoing immune response. The lower affinity receptor, composed of just the IL-2β and IL-2γ components, is more often
found on “naive” immune cells, which are awaiting instructions before seeking out cancer cells.

 

Altering IL-2’s propensity for binding
these receptors could encourage greater immune cell activation or block the function of regulatory cells. Medicenna’s MDNA109
and MDNA209 platforms take advantage of this dynamic by binding to specific receptors and either activating or blocking them.

 

MDNA209 can be used to induce the opposite
effect. This Superkine mimics the shape of IL-2 and is also up to 200-1000 times more likely to bind IL-2Rβ. But rather than
triggering IL-2 signaling, MDNA209 acts as an antagonist, blocking the receptor and preventing it from transmitting the signal.
This could be used for diseases such as such as multiple sclerosis where it is essential to prevent T cells from becoming
activated and attacking healthy tissue. Limited work on MDNA209 has been initiated but development timelines have not been established
at this time.

 

    	 	 	23

     

    

 

MDNA109 Platform Development

 

MDNA109 is an enhanced version of IL-2
that binds up to 200-1000 times more effectively to IL-2Rβ, thus greatly increasing its ability to activate and proliferate
the immune cells needed to fight cancer. Because it preferentially binds IL-2Rβ, MDNA109 drives effector T cell responses
over regulatory T cells. Mutations in the core of IL-2 improve affinity to CD122 on CD8 T cells and NK Cells, as CD122 affinity
is key for the activation of immune cells responsible for cancer killing (CD8+ T cells, naive T cells, NK cells).

 

 

 

Additionally, MDNA109 reverses NK cell
anergy and acts with exceptional synergy when combined with checkpoint inhibitors.

 

    	 	 	24

     

    

 

 

 

One of the development challenges with
MDNA109 was its short half-life, similar to native IL-2, which would require frequent dosing in a commercial setting. In order
to extend the half-life of MDNA109, Medicenna fused inactive protein scaffolds to MDNA109 including Fc-fusions (Fc) and Albumin
fusions (Alb) and, on August 2, 2018, we announced preliminary preclinical data on MDNA109, showing that these fusions are
long-acting and provided the convenience of easier dosing without sacrificing its safety and efficacy.

 

Further modifications were made to MDNA109
in its extended half-life forms to enhance pharmacodynamics and further enhance selectivity in order to reduce binding to CD25
which is associated with the toxic side effect profile of Proleukin. These modifications have provided us with two lead candidates
in development, MDNA19 and MDNA11.

 

 

 

    	 	 	25

     

    

 

On February 6, 2019, the Company presented
results on MDNA109 and its long acting variants in a podium presentation entitled “Putting Pedal to the Metal: Combining
IL-2 Superkine (MDNA109) with Checkpoint Inhibitors”, by Moutih Rafei, PhD, Associate Professor, Department of Pharmacology
and Physiology, Université de Montréal, at the 5th Annual Immuno-Oncology 360° Meeting in New York, NY.

 

The results presented demonstrated that
MDNA109 exhibited 1000-fold enhanced affinity toward the CD122 receptor and best-in-class potency toward cancer killing effector
T cells. When tested in vivo, MDNA109 was not immunogenic and led to potent delay in the growth of pre-established
B16F10 melanoma tumors compared to IL-2. Likewise, significant delay in the growth of pre-established MC38 and CT-26 colon cancer
was observed in syngeneic mice receiving MDNA109, whereas its co-administration with anti-PD1 checkpoint inhibitor eliminated tumors
in 90% of MC38 tumor-bearing mice. Furthermore, MDNA109 in combination with anti-CTLA-4 antibody, complete responses were observed
in a majority of mice in the CT26 model. When cured animals were re-challenged on the counter-lateral flank with CT26 tumor cells,
tumor growth was blocked at the secondary site clearly suggesting the generation of potent memory responses. Additional results
on long-acting MDNA109 variants with impaired CD25 binding demonstrated abrogation of regulatory T cell activation at therapeutic
doses in order to mitigate peripheral side effects, which are dependent on CD25 binding.

 

Medicenna presented a poster entitled “Engineering
a long-acting CD122 biased IL-2 superkine displaying potent anti-tumoral responses” at the Inaugural Immuno-Oncology Pharma
Congress, held from June 18-20, 2019 during World Pharma Week in Boston, MA. Highlights from the presentation by Dr. Moutih
Rafei included the following: (a) When MDNA109-LA was co-administered with the immune-checkpoint blocker anti-cytotoxic T-Lymphocyte-Associated
Protein (“CTLA”) in a colon cancer mouse model, 67% of animals with pre-established tumors remained tumor-free for
over 100 days. When these animals received a second and third re-challenge of the tumor without further treatment, 100% and 75%
remained tumor free, respectively, demonstrating a strong memory response. (b) A long-acting variant, MDNA19, engineered to
mitigate Treg activation by abolishing binding to the CD25 had 50-fold decreased Treg activity and 6-fold higher activity towards
naive CD8 T cells for an overall 300-fold preferential activation of cancer killing T cells than recombinant IL-2. (c) In
addition, binding affinity studies using surface plasmon resonance confirmed absence of CD25 binding by MDNA19. (d) To further
validate the potency of MDNA19 mice with pre-established aggressive B16F10 melanoma tumors showed potent tumor control with a weekly
dosing schedule.

 

On
September 26, 2019, Medicenna announced the publication of a peer-reviewed article in the August 2019 edition of Nature
Communications providing independent third-party validation of Medicenna’s IL-2 Superkine platform, MDNA109. The
publication, titled “A next-generation tumor-targeting IL-2 preferentially promotes tumor infiltrating CD8+ T cell response
and effective tumor control”, describes the safety, efficacy, pharmacokinetics, immunogenicity as well as efficacy profile
in different tumor models of long-acting variants of MDNA109 including fusions to antibodies to create tumor targeted immunocytokines.
The work reported in the publication is covered by Medicenna’s patents and patents in-licensed by the Company.

 

On
September 30, 2019, Medicenna announced the presentation by Dr. Minh To, Director of Preclinical Development at Medicenna,
of preclinical data to support the differentiating characteristics of long-acting MDNA109 variants and their potency in vitro
and in vivo from other long-acting IL-2 programs.

 

    	 	 	26

     

    

 

 

Highlights from the presentation included:

 

		o	High potency towards naive effector T cells but diminished potency on unwanted regulatory T
cells (Tregs). Of the long-acting MDNA109 variants, MDNA19 is superior in having decreased binding to CD25 and increased affinity
to CD122, therefore selectively activating cancer killing CD8 T cells instead of tumor protecting Tregs.

 

		o	Potent effects as monotherapy with improved PK characteristics. In CT26 (mouse colon cancer)
and B16F10 (mouse melanoma) models, treatment with long acting variants of MDNA109 (biweekly for 2 weeks or once weekly for 2 or
3 weeks) potently inhibited tumor growth. These data suggest that long-acting MDNA109 variants could lead to potent therapeutic
effects with a dosing schedule similar to that used for immune checkpoint inhibitors. In addition, the results also confirm that
different protein scaffolds may be used to extend the half-life of MDNA109 and can provide similar tumor control as MDNA19.

 

		o	Compelling preclinical synergism with immune checkpoint inhibition. In a pre-established
colon cancer CT26 model, long-acting MDNA109 variants co-administered with the immune-checkpoint blocker anti-cytotoxic T-Lymphocyte-Associated
Protein (CTLA), showed significant tumor growth inhibition with as many as 89% of animals remaining tumor-free for over 175 days.

 

		o	Strong Memory Response. Furthermore, tumor free animals receiving a second and third re-challenge
of the tumor without further treatment remained tumor free in up to 100% of mice, demonstrating development of a strong memory
response with the ability to prevent tumor relapses.

 

On March 25,
2020, Medicenna announced preclinical data, including NHP data from MDNA19, during a conference call and webcast.

 

The presentation
highlighted data from the long-acting variant MDNA19, engineered to have enhanced binding to CD122 without binding to CD25 and
included:

 

		·	Kinetic studies in NHP showed a dose-dependent
upregulation of Ki67 in CD8 T cells lasting for almost two weeks post-MDNA19 administration, with no apparent side effects.

 

		·	When administered to NHP, MDNA19 increases
the absolute number of circulating CD8 T cells in the absence of Treg and eosinophil stimulation (the latter being a major source
of IL-5 production which is responsible for triggering vascular leak syndrome and associated toxicity)

 

		·	MDNA19 administration as a monotherapy
in syngeneic mice with pre-established CT26 colon cancer led to 60% survival and induction of strong and long-lasting memory responses
correlating with resistance to subsequent re-challenges.

 

		·	Furthermore, MDNA19 treatment of B16F10
tumors favoured activation of CD8 T cells over Tregs in the tumor microenvironment driving a strong therapeutic effect.

 

Medicenna has commenced GLP and GMP related
manufacturing activities with the intention of starting IND enabling studies in the second half of calendar 2020 and initiating
a Phase 1/2a clinical trial in mid 2021. These timelines are later than what was previously disclosed as additional optimization
to the molecules in development was necessary to to further enhance Medicenna's long acting MDNA109 program as potentially best
in class.

 

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Additional funding will be required to
achieve the Company’s business objectives with respect to the completion of the clinical development (Phase 2b and 3 clinical
trials) and commercialization of MDNA19 or MDNA11. The Company expects the completion of clinical development of MDNA19 or MDNA11,
if undertaken by Medicenna, to last until at least 2027, with a projected aggregate cost of approximately $125 million, incremental
to the current funds available to the Company. It is anticipated that following the completion of a Phase 1/2a clinical trial,
the Company will either license the program to one or more partners who would continue the clinical development or raise additional
capital at that time. Additional time and capital would also be required to obtain pre-market approval for MDNA19 or MDNA11 and
to complete business development, marketing and other pre-commercialization activities related to commercial launch.

 

IL2 Superkine Competition

 

The development of next-generation IL-2 agonists for
cancer immunotherapy is an area of intense interest within the biotechnology industry. The Company is aware of several IL-2 agonists in
various stages of clinical development as noted in the table below.

 

	Developer	 	Name	 	Stage
	Nektar Therapeutics	 	NKTR-214	 	Phase 3
	Roche	 	RG7461	 	Phase 2
	Alopexx	 	DI-Leu16-IL2	 	Phase 2
	Philogen	 	Darleukin	 	Phase 2
	Apeiron	 	Hu14.18-IL2	 	Phase 1
	Alkermes	 	ALKS 4230	 	Phase 1/2
	Cue Biopharma	 	CUE-101	 	Phase 1
	Sanofi (formerly Synthorx)	 	THOR-707	 	Phase 1
	Neoleukin	 	NL-201	 	Preclinical
	Pivotal Biosciences	 	PB101	 	Preclinical
	BioNTech	 	BNT151	 	Preclinical
	Ascendis Pharma	 	Transcon IL-2	 	Preclinical

 

Many of the programs in development that
are ahead of Medicenna are engineered variants of IL-2 that each attempt to reduce CD25 binding and extend
the therapeutic window of native IL-2. To our knowledge Medicenna is the only IL-2 product in development which significantly reduces
CD25 binding while also increasing CD122 binding which increases efficacy. In addition to these benefits our candidates MDNA19
and MDNA11 also increase the half-life to allow for dosing every 2 or 3 weeks.

 

IL-4 and IL-13 Superkines

 

Medicenna’s IL-4 and IL-13 Superkines
are engineered versions of wild type cytokines which possess enhanced affinity and selectivity for either the Type 1 or Type 2
IL4R. This selectivity is achieved through mutations of the IL-4 or IL-13 proteins to enhance affinity for binding to specific
IL4R subunits. Additional mutations have also been engineered to modulate their bioactivity, resulting in Superkines with enhanced
signaling (super-agonists) or the ability to block signaling (super-antagonists).

 

One promising IL-13 Superkine antagonist
is MDNA413. Compared to wild type IL-13, MDNA413 has been engineered to have 2,000-fold higher selectivity for the Type 2 IL4R
and which potently blocks IL-4 and IL-13 signaling (Moraga et al, 2015). Blocking of Type 2 IL4R by MDNA413 may be relevant not
only for targeting solid tumors that overexpress this receptor, but also the Th2 biased tumour microenvironment, which shields
the cancer from the immune system.

 

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Another promising IL-13 Superkine is MDNA132.
Unlike MDNA413, MDNA132 is an IL-13 ligand that has been engineered to increase affinity for IL13R alpha2 overexpressed on certain
solid tumors while exhibiting sharply decreased affinity for IL13R alpha1. Medicenna believes MDNA132 has superior targeting compared
to other IL-13 variants in development, and is an attractively differentiated targeting domain for inclusion in new and exciting
field of immuno-oncology based on the CAR-T platform.

 

Limited work on MDNA413 and MDNA132 were
completed in the past three years and development timelines for MDNA413 and MDNA132 have yet to be established.

 

Trends

 

The Company anticipates that its current
level of cash and cash equivalents and marketable securities, including the over-allotment exercised subsequent to the year end,
will be sufficient to execute its current planned expenditures for more than the next 24 months without further financing being
obtained. This estimate assumes continued development of MDNA55 to the End of Phase 2 regulatory meeting with the FDA, completion
of non-GLP and GLP pre-clinical studies, GMP manufacturing for pre-clinical and clinical studies of MDNA19 or MDNA11 as well as
initiation and completion of Phase 1/2a clinical studies for MDNA11 or MDNA19. It does not factor in any future warrant exercises
or reimbursement from CPRIT.

 

Based on the above, Medicenna currently
anticipates an increase in expenditures relating to Medicenna’s preclinical programs, specifically the MDNA109 platform as
it moves toward the clinic in 2021. However, expenditures on the MDNA55 clinical trial are expected to decrease as the clinical
development is complete and additional development will not begin without additional funding being obtained. Accordingly, cash
burn is projected to increase over the next 12 months and the Company has sufficient capital to execute its planned operations
for more than the next 24 months.

 

Intellectual Property and Partnerships

 

Medicenna regards its intellectual property
rights as one of the foundation blocks upon which it continues to build a successful biopharmaceutical development company. Medicenna
has established a strong and defensive intellectual property position to protect its proprietary technologies. To date, Medicenna
has 16 patent families providing patent protection in the US and in contracting states to the Patent Corporation Treaty. The company
has a total of eleven issued patents and several patent applications pending in the United States, as well as a number of granted
and pending applications worldwide.

 

Patent families owned or licensed by Medicenna
related to MDNA55 (granted US cases listed):

 

		1.	Method for Convection Enhanced Delivery of Therapeutic Agents (U.S. Patent No. 7,371,225)

 

		2.	Targeted Cargo Protein Combination Therapy (U.S. Patent No. 9,629,899)

 

		3.	IL-4 Fusion Formulations for Treatment of Central Nervous System Tumors

 

		4.	Treating Cancer Stem Cells Using Targeted Cargo Proteins

 

		5.	ILR4 as a Biomarker in Cancer (patent pending)

 

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Expiry dates for the above patents and
related family members range from 2023 to 2040.

 

In addition to the above patent protection,
MDNA55 has market exclusivity via Orphan Drug Designation in the United States (7 years) and Europe (10 years) for the treatment
of GBM, as well as, Biologics Data Exclusivity in the United States (12 years), Europe (10 years), Canada (8 years) and other
markets where similar means of exclusivity are available.

 

Patent families owned or licensed by Medicenna
related to the Superkine and Empowered Superkine platforms (granted US cases listed):

 

		1.	Superagonists and Antagonists of Interleukin-2 (U.S. Patent No. 9,428,567 and U.S. Patent
No. 10,183,980)

 

		2.	Superkines and Synthekines: Repurposed Cytokines with New and Enhanced Signaling Activities (U.S.
Patent No. 9,738,696)

 

		3.	Therapeutic IL-13 Polypeptides (U.S. Patent No. 9,512,194, U.S. Patent No. 9,732,133,
and U.S. Patent No. 10,227,389)

 

		4.	Interleukin-4 Receptor-Binding Fusion Proteins and Uses Thereof (Pro-apoptotic Fusions) (U.S. Patent
No. 10,093,708)

 

		5.	Interleukin-4 Receptor Binding Fusion Proteins and Uses Thereof (Anti-apoptotic Fusions) (U.S.
Patent No. 10,106,592)

 

		6.	IL-13 Superkine: Immune Cell Targeting Constructs and Methods of Use Thereof

 

		7.	IL-2 Fusion Proteins and Uses Thereof

 

		8.	Superagonists, Partial Agonists and Antagonists of Interleukin-2 (U.S. Patent No. 10,150,802)

 

		9.	IL-13 Superkine: Immune Cell Targeting Constructs and Methods of Use Thereof (patent pending)

 

		10.	IL-2 Superagonists in Combination with Anti-PD-1 Antibodies

 

		11.	Uses and Methods for Oncolytic Virus Targeting of IL-4/IL-13 and Fusions (patent pending)

 

Expiry dates for the above patents and
related family members range from 2031 to 2039. Medicenna has Biologics Data Exclusivity for the above programs in the United States
(12 years), Europe (10 years), Canada (8 years) and in other markets where similar means of exclusivity are available.

 

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CPRIT Agreement

 

In February 2015, the Company was
awarded a grant by CPRIT whereby the Company is eligible to receive up to US$14,100,000 on eligible expenditures over a three-year
period related to the development of the Company’s Phase 2b clinical program for MDNA55. In October 2017 the Company
was granted a one year extension to the grant, allowing expenses to be claimed over a four-year period ending February 28,
2019. On February 4, 2019 the Company was approved for a further six-month extension until August 31, 2019 and on July 25,
2019 an additional six-month extension was granted to February 28, 2020 and on January 6, 2020 an additional six-month
extension was granted to August 28, 2020. The Company does not anticipate requiring any additional extensions to the timelines.

 

Ongoing program funding from CPRIT is subject
to a number of conditions including the satisfactory achievement of milestones that must be met to release additional CPRIT funding,
evidence that the Company has raised 50% matching funds and maintaining substantial functions of the Company related to the project
grant in Texas as well as using Texas-based subcontractors and collaborators wherever possible. There can be no assurances that
the Company will continue to meet the necessary CPRIT criteria or that CPRIT will continue to advance additional funds to the Company.

 

If the Company is found to have used any
grant proceeds for purposes other than intended, is in violation of the terms of the grant, or relocates its MDNA55 related operations
outside of the state of Texas, then the Company is required to repay any grant proceeds received.

 

Under the terms of the grant, the Company
is also required to pay a royalty to CPRIT, comprised of 3-5% of revenues on net sales of MDNA55 until aggregate royalty payments
equal 400% of the grant funds received, at which time the ongoing royalty will be 0.5%.

 

Business Strategy

 

Medicenna’s strategy to reduce risk
is to diversify the assets in Medicenna’s pipeline based on their stage of development, mechanism of action and target product
profile. To achieve this goal, we in-licensed the Superkine platform from Stanford. These candidates, namely IL-2, IL-4 and
IL-13 Superkines, of which the lead preclinical program is based on the IL-2 super-agonist platform, MDNA109are expected to enable
the company to develop a library of cytokine candidates. The resulting early stage preclinical product candidates derived from
the Superkine and EC platforms have a different mechanism of action and target product profile compared to MDNA55, Medicenna’s
late stage candidate. By adopting a balanced approach, Medicenna is less reliant on a single product in Medicenna’s pipeline,
with greater upside potential through opportunities to partner or develop on its own, multiple products. Medicenna believes that
establishing a pipeline of drug candidates with distinct mechanisms of actions targeting multiple disease indications mitigates
development risk. Medicenna intends to achieve its business strategy by focusing on the following key areas:

 

		1.	Maximize the potential clinical and commercial success of Medicenna’s drug candidates by
pursuing development programs based on sound scientific rationale for multiple disease indications where there are significant
unmet clinical needs. In the near-term, Medicenna’s focus will be to advance MDNA55 for the treatment of rGBM through to
EOP2 meeting with the FDA as well advance the MDNA109 platform into IND enabling studies followed by Phase 1/2a clinical development;

 

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		2.	Optimize the therapeutic potential of Medicenna’s drug candidates by selecting sub-populations
of patients who stand an improved chance of responding to treatment and employing the latest technologies and strategies for optimizing
drug delivery;

 

		3.	Establish collaborations and relationships with leading scientific and clinical centres to effectively
maximize the success of Medicenna’s drug development programs; and

 

		4.	Assess strategic alliances with select pharmaceutical and/or biotechnology companies where such
alliances may enable successful development and commercialization of Medicenna’s drug candidates while maximizing its return
on investment. Medicenna may conduct transactions with established strategic partners on a regional or worldwide basis to accelerate
product development, improve Medicenna’s marketing strength and enhance its capability of bringing products to the markets
worldwide.

 

Medicenna will continue to seek sources
of non-dilutive funding as well as additional funds through equity financings and/or through collaborative arrangements with pharmaceutical
and/or biotechnology companies for any of Medicenna’s products and technologies under development. Cash resources are carefully
managed and focused on priority programs and initiatives. Accordingly, some initiatives may not be pursued or advanced in the near
term as a prudent measure to preserve cash.

 

Regulatory Process

 

Government authorities in the United States,
including federal, state, and local authorities, and in other countries, extensively regulate, among other things, the manufacturing,
research and clinical development, marketing, labeling and packaging, storage, distribution, post-approval monitoring and reporting,
advertising and promotion, and export and import of biological products, such as those Medicenna is developing. The process of
obtaining regulatory approvals and the subsequent compliance with appropriate federal, state, local, and foreign statutes and regulations
require the expenditure of substantial time and financial resources.

 

Securing final regulatory approval for
the manufacture and sale of biological products in the United States, Europe, Canada and other commercial territories, is a long
and costly process that is controlled by that particular territory’s regulatory agency. The regulatory agency in the United
States is the FDA, in Canada it is Health Canada, and in Europe it is the EMA. Other regulatory agencies have similar regulatory
approval processes, but each regulatory agency has its own approval processes. Approval in the United States, Canada or Europe
does not assure approval by other regulatory agencies, although often test results from one country may be used in applications
for regulatory approval in another country.

 

None of Medicenna’s products have
been completely developed or tested and, therefore, Medicenna is not yet in a position to seek final regulatory approval to market
any of Medicenna’s products. The time required to obtain approval by such regulatory authorities is unpredictable but typically
takes many years following the commencement of preclinical studies and clinical trials and will require significant additional
capital. See “Risk Factors” below.

 

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United States Government Regulation

 

In the United States, the FDA regulates
drugs under the Federal Food, Drug, and Cosmetic Act (“FDCA”), and its implementing regulations, and biologics
under the FDCA and the Public Health Service Act (“PHSA”), and its implementing regulations. FDA approval is
required before any new unapproved drug or biologic or dosage form, including a new use of a previously approved drug, can be marketed
in the United States. Drugs and biologics are also subject to other federal, state, and local statutes and regulations. If Medicenna
fails to comply with applicable FDA or other requirements at any time during the product development process, clinical testing,
the approval process or after approval, Medicenna may become subject to administrative or judicial sanctions. These sanctions could
include the FDA’s refusal to approve pending applications, license suspension or revocation, withdrawal of an approval, warning
letters, product recalls, product seizures, total or partial suspension of production or distribution, civil monetary penalties
or criminal prosecution. Any FDA enforcement action could have a material adverse effect on Medicenna.

 

The process required by the FDA before
product candidates may be marketed in the United States generally involves the following:

 

		·	completion of extensive preclinical laboratory
tests and preclinical animal studies, all performed in accordance with the Good Laboratory Practices (“GLP”) regulations;

 

		·	completion of extensive CMC (chemistry,
manufacturing and control) to produce drug in accordance with current Good Manufacturing Practices (“cGMP”);

 

		·	submission to the FDA of an IND, which
must become effective before human clinical trials may begin and must be updated annually;

 

		·	approval by an independent institutional
review board (“IRB”) or ethics committee representing each clinical site before each clinical trial may be initiated;

 

		·	performance of adequate and well-controlled
human clinical trials to establish the safety and efficacy of the product candidate for each proposed indication;

 

		·	preparation of and submission to the FDA
of a new drug application (“NDA”) or biologics license application (“BLA”) after completion of all pivotal
clinical trials;

 

		·	potential review of the product application
by an FDA advisory committee, where appropriate and if applicable;

 

		·	a determination by the FDA within 60 days
of its receipt of an NDA or BLA to file the application for review;

 

		·	satisfactory completion of an FDA pre-approval
inspection of the manufacturing facilities where the proposed product is produced to assess compliance with cGMP;

 

		·	a potential FDA audit of the preclinical
research and clinical trial sites that generated the data in support of the NDA or BLA; and

 

		·	FDA review and approval of an NDA or BLA
prior to any commercial marketing or sale of the product in the United States

 

The preclinical research, including production
of cGMP material, clinical testing and approval process require substantial time, effort, and financial resources, and Medicenna
cannot be certain that any approvals for Medicenna’s product candidates will be granted on a timely basis, if at all.

 

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An IND is a request for authorization from
the FDA to administer an investigational new drug product to humans in clinical trials. The central focus of an IND submission
is on the general investigational plan and the protocol(s) for human clinical trials. The IND also includes description of
the manufacturing process and testing of the batch, results of animal studies assessing the toxicology, pharmacokinetics, pharmacology,
and pharmacodynamic characteristics of the product; and any available human data or literature to support the use of the investigational
new drug. An IND must become effective before human clinical trials may begin. An IND will automatically become effective 30 days
after receipt by the FDA, unless before that time the FDA raises concerns or questions related to the proposed clinical trials.
In such a case, the IND may be placed on clinical hold and the IND sponsor and the FDA must resolve any outstanding concerns or
questions before clinical trials can begin. Accordingly, submission of an IND may or may not result in the FDA allowing clinical
trials to commence.

 

Clinical Trials

 

Clinical trials involve the administration
of the investigational new drug to human subjects under the supervision of qualified investigators in accordance with Good Clinical
Practices (“GCP”), which include the requirement that all research subjects provide their informed consent for their
participation in any clinical trial. Clinical trials are conducted under protocols detailing, among other things, the objectives
of the study, the parameters to be used in monitoring safety, and the efficacy criteria to be evaluated. A protocol for each clinical
trial and any subsequent protocol amendments must be submitted to the FDA as part of the IND. Additionally, approval must also
be obtained from each clinical trial site’s IRB or ethics committee, before the trials may be initiated, and the IRB or ethics
committee must monitor the trial until completed. There are also requirements governing the reporting of ongoing clinical trials
and clinical trial results to public registries.

 

The clinical investigation of a drug is
generally divided into three or four phases. Although the phases are usually conducted sequentially, they may overlap or be combined.

 

		·	Phase 1. The drug is introduced into healthy
human subjects with the target disease or condition. These studies are designed to evaluate safety, dosage tolerance, metabolism
and pharmacologic actions of the investigational new drug in humans, the side effects associated with increasing doses, and where
possible, to gain early evidence on effectiveness.

 

		·	Phase 2. The drug is administered to a
limited patient population to evaluate dosage tolerance and optimal dosage, identify possible adverse side effects and safety risks,
and preliminarily evaluate efficacy.

 

		·	Phase 3. The drug is administered to an
expanded patient population, generally at geographically dispersed clinical trial sites to generate enough data to statistically
evaluate dosage, clinical effectiveness and safety, to establish the overall benefit-risk relationship of the investigational new
drug product, and to provide an adequate basis for physician labeling.

 

		·	Phase 4. In some cases, the FDA may condition
approval of an NDA or BLA for a product candidate on the sponsor’s agreement to conduct additional clinical trials after
approval. In other cases, a sponsor may voluntarily conduct additional clinical trials after approval to gain more information
about the drug. Such post-approval studies are typically referred to as Phase 4 clinical trials.

 

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Clinical trial sponsors must also report
to the FDA, within certain timeframes, serious and unexpected adverse reactions, any clinically important increase in the rate
of a serious suspected adverse reaction over that listed in the protocol or investigator’s brochure, or any findings from
other studies or animal testing that suggest a significant risk in humans exposed to the product candidate. The FDA, the IRB or
ethics committee, or the clinical trial sponsor may suspend or terminate a clinical trial at any time on various grounds, including
a finding that the research subjects are being exposed to an unacceptable health risk. Additionally, some clinical trials are overseen
by an independent group of qualified experts organized by the clinical trial sponsor, known as a data safety monitoring board or
committee. This group provides authorization for whether or not a trial may move forward at designated check points based on access
to certain data from the trial.

 

The clinical trial process can take years
to complete, and there can be no assurance that the data collected will support FDA approval or licensure of the product. Results
from one trial are not necessarily predictive of results from later trials. Medicenna may also suspend or terminate a clinical
trial based on evolving business objectives and/or competitive climate.

 

Submission of an NDA or BLA to the FDA

 

Assuming successful completion of all required
preclinical studies and clinical testing in accordance with all applicable regulatory requirements, detailed investigational new
drug product information is submitted to the FDA in the form of an NDA or BLA requesting approval to market the product for one
or more indications. Under federal law, the submission of most NDAs and BLAs is subject to an application user fee. For the year
2020, the application user fee exceeds US$2.943 million. This fee is typically increased annually. Applications for orphan drug
products are exempted from the NDA and BLA application user fee, unless the application includes an indication for other than a
rare disease or condition.

 

An NDA or BLA must include all relevant
data available from pertinent preclinical studies and clinical trials, including negative or ambiguous results as well as positive
findings, together with detailed information relating to the product’s chemistry, manufacturing, controls, and proposed labeling,
among other things. Data come from company-sponsored clinical trials intended to test the safety and effectiveness of a use of
a product, and may also come from a number of alternative sources, including trials initiated by investigators. To support marketing
approval, the data submitted must be sufficient in quality and quantity to establish the safety and efficacy of the investigational
new drug product to the satisfaction of the FDA.

 

Once an NDA or BLA has been submitted,
the FDA’s goal is to review the application within ten months after it accepts the application for filing, or, if the application
relates to an unmet medical need in a serious or life-threatening indication, six months after the FDA accepts the application
for filing. The review process is often significantly extended by the FDA’s requests for additional information or clarification.

 

Before approving an NDA or BLA, the FDA
typically will inspect the facility or facilities where the product is manufactured. The FDA will not approve an application unless
it determines that the manufacturing processes and facilities are in compliance with cGMP requirements and adequate to assure consistent
production of the product within required specifications. Additionally, before approving an NDA or BLA, the FDA will typically
inspect one or more clinical sites to assure compliance with GCP.

 

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The FDA is required to refer an NDA or
BLA for a novel drug (in which no active ingredient has been approved in any other application) to an advisory committee or explain
why such referral was not made. Typically, an advisory committee is a panel of independent experts, including clinicians and other
scientific experts, that reviews, evaluates and provides a recommendation as to whether the application should be approved and
under what conditions. The FDA is not bound by the recommendations of an advisory committee, but it considers such recommendations
carefully when making decisions.

 

The FDA’s Decision on an NDA or BLA

 

After the FDA evaluates the NDA or BLA
and conducts inspections of manufacturing facilities where the product will be produced, the FDA will issue either an approval
letter or a complete response letter (“Complete Response Letter”). An approval letter authorizes commercial marketing
of the drug with specific prescribing information for specific indications. A Complete Response Letter indicates that the review
cycle of the application is complete and the application is not ready for approval. In order to satisfy deficiencies identified
in a Complete Response Letter, additional clinical data and/or additional Phase 3 clinical trial(s), and/or other significant,
expensive and time-consuming requirements related to clinical trials, preclinical studies or manufacturing may be required for
the product candidate. Even if such additional information is submitted, the FDA may ultimately decide that the NDA or BLA does
not satisfy the criteria for approval. The FDA could also approve the NDA or BLA with a risk evaluation and mitigation strategy,
plan to mitigate risks, which could include medication guides, physician communication plans, or elements to assure safe use, such
as restricted distribution methods, patient registries and other risk minimization tools. The FDA also may condition approval on,
among other things, changes to proposed labeling, development of adequate controls and specifications, or a commitment to conduct
one or more post-market studies or clinical trials. Such post-market testing may include Phase 4 clinical trials and surveillance
to further assess and monitor the product’s safety and effectiveness after commercialization. New government requirements,
including those resulting from new legislation, may be established, or the FDA’s policies may change, which could delay or
prevent regulatory approval of Medicenna’s products under development.

 

Patent Term Restoration

 

Depending upon the timing, duration, and
specifics of the FDA approval of the use of Medicenna’s product candidates, some of Medicenna’s United States patents
may be eligible for limited patent term extension under the Drug Price Competition and Patent Term Restoration Act of 1984,
commonly referred to as the Hatch-Waxman Amendments. The Hatch-Waxman Amendments permit a patent restoration term of up to five
years as compensation for patent term lost during product development and the FDA regulatory review process. However, patent term
restoration cannot extend the remaining term of a patent beyond a total of 14 years from the product’s approval date. The
patent term restoration period is generally one-half the time between the effective date of an IND and the submission date of an
NDA or BLA, plus the time between the submission date and the approval of that application. Only one patent applicable to an approved
product is eligible for the extension and the application for the extension must be submitted prior to the expiration of the patent
and within 60 days of the product’s approval. The United States Patent and Trademark Office, in consultation with the FDA,
reviews and approves the application for any patent term extension or restoration. In the future, Medicenna may apply for restoration
of patent term for one of Medicenna’s currently owned or licensed patents to add patent life beyond its current expiration
date, depending on the expected length of the clinical trials and other factors involved in the filing of the relevant NDA or BLA.

 

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Companion Diagnostics

 

In its August 6, 2014 guidance document
entitled “In Vitro Companion Diagnostic Devices,” the FDA defines an “IVD companion diagnostic device”
to be an in vitro diagnostic device that provides information that is essential for the safe and effective use of a corresponding
therapeutic product. Use of an IVD companion diagnostic device is considered essential when its use is required in the labeling
of a therapeutic product, for example, to select appropriate patients for a product or those who should not use the product, or
to monitor patients to achieve safety or effectiveness. In most circumstances, the IVD companion diagnostic device should be approved
or cleared by FDA under the device authorities of the FDCA contemporaneously with the therapeutic product’s approval under
section 505 of the FDCA for a drug or section 351 of the PHSA for a biological product. FDA expects the therapeutic product sponsor
to address the need for an approved or cleared IVD companion diagnostic device in its therapeutic product development plan. The
therapeutic product sponsor may develop its own IVD companion diagnostic device, partner with a diagnostic device sponsor to develop
an IVD companion diagnostic device, or explore modifying an existing IVD diagnostic device to develop a new intended use. The FDA
explains if a diagnostic device and a therapeutic device are studied together to support their respective approvals, both products
can be studied in the same investigational study that meets both the requirements of the Investigational Device Exemption, regulations
and the IND regulations.

 

Specialized Skill and Knowledge

 

Medicenna’s business requires personnel
with specialized skills and knowledge in the fields of basic and applied immunotherapy and immunology, oncology in general, the
treatment of GBM, as well as drug delivery to the brain. Medicenna has subcontracted out several key functions to highly specialized
individuals and companies to conduct the preclinical development of MDNA19 and MDNA11, manufacturing of MDNA19 and/or MDNA11 as
well as MDNA55, the clinical program and regulatory activities associated with the EOP2 meetings with the FDA. These programs are
overseen by Medicenna’s Chief Executive Officer, Head of Clinical Development and Chief Development Officer, to ensure proper
and timely completion of the required activities. Medicenna worked with world renowned brain cancer treatment centres for Medicenna’s
Phase 2b clinical trial of MDNA55. In addition, some of the leading experts in North America and Europe with respect to drug delivery
to the brain, contribute towards Medicenna’s clinical and regulatory efforts.

 

Employees

 

As at March 31, 2020, Medicenna had
7 full-time employees and two part-time consultants, including four holding PhD degrees, one holding an MD and other employees
holding M.Sc. and MBA degrees or CPA designations.

 

Medicenna’s employees are not governed
by a collective bargaining agreement. Medicenna depends on certain key members of its management and scientific staff and the loss
of services of one or more of these persons could adversely affect the Company.

 

Medicenna also uses consultants and outside
contractors to carry on many of Medicenna’s activities, including preclinical testing and validation, formulation, assay
development, manufacturing, clinical and regulatory affairs, toxicology and clinical trials.

 

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Legal Proceedings

 

To Medicenna’s knowledge, there have
not been any legal or arbitration proceedings, including those relating to bankruptcy, receivership or similar proceedings, those
involving any third party, and governmental proceedings pending or known to be contemplated, which may have, or have had in the
recent past, significant effect Medicenna’s financial position or profitability.

 

To Medicenna’s knowledge, there have
been no material proceedings in which any director, any member of senior management, or any of Medicenna’s affiliates is
either a party adverse to Medicenna or any of Medicenna’s subsidiaries or has a material interest adverse to Medicenna or
any of Medicenna’s subsidiaries.

 

RISK
FACTORS

 

An investment in the Common Shares involves
a high degree of risk and should be considered speculative. An investment in the Common Shares should only be undertaken by those
persons who can afford the total loss of their investment. Investors should carefully consider the risks and uncertainties set
forth below, as well as other information described elsewhere in this AIF. The risks and uncertainties below are not the only ones
the Company faces. Additional risks and uncertainties not presently known to Medicenna or that Medicenna believes to be immaterial
may also adversely affect Medicenna’s business. If any of the following risks occur, Medicenna’s business, financial
condition and results of operations could be seriously harmed and you could lose all or part of your investment. Further, if Medicenna
fails to meet the expectations of the public market in any given period, the market price of Medicenna’s Common Shares could
decline. Medicenna operates in a highly competitive environment that involves significant risks and uncertainties, some of which
are outside of Medicenna’s control.

 

Risks Related to the Company’s Business and the
Company’s Industry

 

The Company has no sources of product
revenue and will not be able to maintain operations and research and development without sufficient funding.

 

The Company has no sources of product revenue
and cannot predict when or if it will generate product revenue. The Company’s ability to generate product revenue and ultimately
become profitable depends upon its ability, alone or with partners, to successfully develop the product candidates, obtain regulatory
approval, and commercialize products, including any of the current product candidates, or other product candidates that may be
developed, in-licensed or acquired in the future. The Company does not anticipate generating revenue from the sale of products
for the foreseeable future. The Company expects research and development expenses to increase in connection with ongoing activities,
particularly as MDNA55 is advanced through clinical trials and the MDNA109 platform (MDNA19 or MDNA11) is advanced towards the
clinic.

 

The Company will require significant additional
capital resources to expand its business, in particular the further development of its proposed products. Advancing its product
candidates or acquisition and development of any new products or product candidates will require considerable resources and additional
access to capital markets. In addition, the Company’s future cash requirements may vary materially from those now expected.

 

The Company can potentially seek additional
funding through corporate collaborations and licensing arrangements, through public or private equity or debt financing, or through
other transactions. However, if clinical trial results are neutral or unfavourable, or if capital market conditions in general,
or with respect to life sciences companies such as Medicenna, are unfavourable, the Company’s ability to obtain significant
additional funding on acceptable terms, if at all, will be negatively affected. Additional financing that it may pursue may involve
the sale of the Common Shares or financial instruments that are exchangeable for, or convertible into, the Common Shares, which
could result in significant dilution to its shareholders. If sufficient capital is not available, the Company may be required to
delay the implementation of its business strategy, which could have a material adverse effect on its business, financial condition,
prospects or results of operations.

 

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The Company is highly dependent upon
certain key personnel and their loss could adversely affect the its ability to achieve its business objective.

 

The loss of Dr. Fahar Merchant, the
President and Chief Executive Officer, Rosemina Merchant, the Chief Development Officer, or other key members of the scientific
and operating staff could harm the Company. Employment agreements exist with Dr. Merchant and Ms. Merchant, although
such employment agreements do not guarantee their retention. The Company also depends on scientific and clinical collaborators
and advisors, all of whom have outside commitments that may limit their availability. In addition, the Company believes that future
success will depend in large part upon its ability to attract and retain highly skilled scientific, managerial, medical, clinical
and regulatory personnel. Agreements have been entered into with scientific and clinical collaborators and advisors, key opinion
leaders and academic partners in the ordinary course of business as well as with physicians and institutions who recruited patients
into the MDNA55 clinical trial and will recruit patients into future clinical trials. Notwithstanding these arrangements, there
is significant competition for these types of personnel from other companies, research and academic institutions, government entities
and other organizations. The loss of the services of any of the executive officers or other key personnel could potentially harm
the Company’s business, operating results or financial condition.

 

If the Company breaches any of the
agreements under which it licenses rights to product candidates or technology from third parties, it can lose license rights that
are important to its business. The Company’s current license agreements may not provide an adequate remedy for breach by
the licensor.

 

The Company is developing MDNA55, the MDNA109
platform (MDNA19 and MDNA11) and other earlier stage preclinical and discovery drug candidates pursuant to license agreements with
NIH and Stanford (collectively, the “Licensors”). The Company is subject to a number of risks associated with its collaboration
with the Licensors, including the risk that the Licensors may terminate the license agreement upon the occurrence of certain specified
events. The license agreement requires, among other things, that the Company makes certain payments and use reasonable commercial
efforts to meet certain clinical and regulatory milestones. If the Company fails to comply with any of these obligations or otherwise
breach this or similar agreements, the Licensors or any future licensors may have the right to terminate the license in whole.
The Company can also suffer the consequences of non-compliance or breaches by Licensors in connection with the license agreements.
Such non-compliance or breaches by such third parties can in turn result in breaches or defaults under the Company’s agreements
with other collaboration partners, and the Company can be found liable for damages or lose certain rights, including rights to
develop and/or commercialize a product or product candidate. Loss of the Company’s rights to the licensed intellectual property
or any similar license granted to it in the future, or the exclusivity rights provided therein, can harm the Company’s financial
condition and operating results.

 

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Clinical drug development involves
a lengthy and expensive process with an uncertain outcome, results of earlier studies and trials may not be predictive of future
trial results, and the Company’s product candidates may not have favourable results in later trials or in the commercial
setting.

 

Clinical testing is expensive and can take
many years to complete, and its outcome is inherently uncertain. Failure can occur at any time during the clinical trial process.
The results of preclinical studies and early clinical trials may not be predictive of the results of later-stage clinical trials.
In the case of MDNA55, the promising results seen in the Phase 2b clinical study may not be replicated in a randomized, controlled
Phase 3 clinical study. Success in preclinical or animal studies and early clinical trials does not ensure that later large-scale
efficacy trials will be successful nor does it predict final results. This is applicable to the MDNA109 platform (MDNA19 and MDNA11)
as the promising preclinical data may not be replicated in a clinical setting. Favourable results in early trials may not be repeated
in later trials. There is no assurance the FDA, the EMA or other similar government bodies will view the results as the Company
does or that any future trials of its proposed products for other indications will achieve positive results. Product candidates
in later stages of clinical trials may fail to show the desired safety and efficacy traits despite having progressed through preclinical
studies and initial clinical trials.

 

The Company will be required to demonstrate
through larger-scale clinical trials that any potential future product is safe and effective for use in a diverse population before
it can seek regulatory approvals for commercial sale of its product. There is typically an extremely high rate of attrition from
the failure of product candidates proceeding through clinical and post-approval trials. If MDNA55 fails to demonstrate sufficient
safety and efficacy in future clinical trials, the Company’s operations and financial condition will be adversely impacted.

 

If the Company’s competitors
develop and market products that are more effective than the Company’s existing product candidates or any products it may
develop, or if they obtain marketing approval before it does, the Company’s products may be rendered obsolete or uncompetitive.

 

Technological competition from pharmaceutical
companies, biotechnology companies and universities is intense and is expected to increase. Many of the Company’s competitors
and potential competitors have substantially greater product development capabilities and financial, scientific, marketing and
human resources than the Company does. Our future success depends in part on our ability to maintain a competitive position, including
our ability to further progress MDNA55 and the MDNA109 platform (MDNA19 and MDNA11) through the necessary preclinical and clinical
trials towards regulatory approval for sale and commercialization. Other companies may succeed in commercializing products earlier
than we are able to commercialize our products or they may succeed in developing products that are more effective than our products.
While the Company will seek to expand its technological capabilities in order to remain competitive, there can be no assurance
that developments by others will not render its products non-competitive or that the Company or its licensors will be able to keep
pace with technological developments. Competitors have developed technologies that could be the basis for competitive products.
Some of those products may have an entirely different approach or means of accomplishing the desired therapeutic effect than the
Company’s products and may be more effective or less costly than its products. In addition, other forms of medical treatment
may offer competition to the products. The success of the Company’s competitors and their products and technologies relative
to its technological capabilities and competitiveness could have a material adverse effect on the future preclinical and clinical
trials of its products, including its ability to obtain the necessary regulatory approvals for the conduct of such trials.

 

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The Company is subject to the restrictions
and conditions of the CPRIT agreement. Failure to comply with the CPRIT agreement may adversely affect the Company’s financial
condition and results of operations.

 

The Company has obtained a grant from CPRIT
to fund a portion of its operations to date. The CPRIT grant is subject to the Company’s compliance with the scope of work
outlined in the CPRIT agreement and demonstration of its progress towards achievement of the milestones set forth in the CPRIT
agreement. If the Company fails to comply with the terms of the CPRIT agreement, it may not receive the remaining US$1.4 million
tranche of the CPRIT grant or it may be required to reimburse some or the entire CPRIT grant. Further, the CPRIT grant may only
be applied to a limited number of allowable expenses. Failure to obtain the remaining tranche of the CPRIT grant or being required
to reimburse all or a portion of the CPRIT grant may cause a halt or delay in ongoing operations, which may adversely affect the
Company’s financial condition and operating results.

 

The Company relies and will continue
to rely on third parties to plan, conduct and monitor preclinical studies and clinical trials, and their failure to perform as
required could cause substantial harm to the Company’s business.

 

The Company relies and will continue to
rely on third parties to conduct a significant portion of clinical development and planned preclinical activities. Preclinical
activities include in vivo studies providing access to specific disease models, pharmacology and toxicology studies, and
assay development. Clinical development activities include trial design, regulatory submissions, clinical patient recruitment,
clinical trial monitoring, clinical data management and analysis, safety monitoring and project management. If there is any dispute
or disruption in the Company’s relationship with third parties, or if the Company is unable to provide quality services in
a timely manner and at a feasible cost, any active development programs could face delays. Further, if any of these third parties
fails to perform as expected or if their work fails to meet regulatory requirements, testing could be delayed, cancelled or rendered
ineffective.

 

The Company relies on contract manufacturers
over whom the Company has limited control. If the Company is subject to quality, cost or delivery issues with the preclinical and
clinical grade materials supplied by contract manufacturers, business operations could suffer significant harm.

 

The Company has limited manufacturing experience
and relies on contract development and manufacturing organizations (“CDMOs”), to manufacture MDNA55 for clinical trials
and the MDNA109 platform (MDNA19 or MDNA11) for preclinical development. The Company relies on CDMOs for manufacturing, filling,
packaging, storing and shipping of drug product in compliance with cGMP, regulations applicable to its products. The FDA ensures
the quality of drug products by carefully monitoring drug manufacturers’ compliance with cGMP regulations. The cGMP regulations
for drugs contain minimum requirements for the methods, facilities and controls used in manufacturing, processing and packing of
a drug product. The Company plans to utilize CDMOs that are licensed by both the FDA and the EMA.

 

There can be no assurances that the CDMOs
selected will be able to meet future timetables and requirements. If the Company is unable to arrange for alternative third-party
manufacturing sources on commercially reasonable terms or in a timely manner, it may delay the development of the product candidates.
Further, contract manufacturers must operate in compliance with cGMP and failure to do so could result in, among other things,
the disruption of product supplies. The Company’s dependence upon third parties for the manufacture of its products may adversely
affect profit margins and ability to develop and deliver products on a timely and competitive basis.

 

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The Company’s future success
is dependent primarily on the regulatory approval of a single product.

 

The Company does not have any products
that have gained regulatory approval. Currently, its only clinical product candidate is MDNA55. As a result, the Company’s
near-term prospects, including its ability to finance its operations and generate revenue, are substantially dependent on its ability
to obtain regulatory approval for, and, if approved, to successfully commercialize MDNA55 in a timely manner. The Company cannot
commercialize MDNA55 or other future product candidates in the United States without first obtaining regulatory approval for the
product from the FDA; similarly, it cannot commercialize MDNA55 or other future product candidates outside of the United States
without obtaining regulatory approval from comparable foreign regulatory authorities. Although MDNA55 has received Orphan Drug
(FDA, EMA) and Fast Track (FDA) designations, there can be no assurance regulatory approval will be granted. Before obtaining regulatory
approvals for the commercial sale of MDNA55 or other future product candidates for a target indication, the Company must demonstrate
with substantial evidence gathered in preclinical and clinical studies to the satisfaction of the relevant regulatory authorities,
that the product candidate is safe and effective for use for that target indication and that the manufacturing facilities, processes
and controls are adequate. Many of these factors are beyond the Company’s control. If the Company, or its potential commercialization
collaborators, are unable to successfully commercialize MDNA55, the Company may not be able to earn sufficient revenues to continue
its business.

 

The Company may not achieve its publicly
announced milestones according to schedule, or at all.

 

From time to time, the Company may announce
the timing of certain events expected to occur, such as the anticipated timing of results from clinical trials. These statements
are forward-looking and are based on the best estimates of management at the time relating to the occurrence of such events. However,
the actual timing of such events may differ from what has been publicly disclosed. The timing of events such as initiation or completion
of a clinical trial, filing of an application to obtain regulatory approval, or announcement of additional clinical trials for
a product candidate may ultimately vary from what is publicly disclosed. These variations in timing may occur as a result of different
events, including the ability to recruit patients in a clinical trial in a timely manner, the nature of results obtained during
a clinical trial or during a research phase, problems with a CDMO or a contract research organization (“CRO”), or any
other event having the effect of delaying the publicly announced timeline. The Company undertakes no obligation to update or revise
any forward-looking information, whether as a result of new information, future events or otherwise, except as otherwise required
by law. Any variation in the timing of previously announced milestones could have a material adverse effect on the business plan,
financial condition or operating results and the trading price of the Common Shares.

 

MDNA55 is in the mid stages of clinical
development and the MDNA109 platform (MDNA19 and MDNA11) in preclinical development and, as a result, the Company will be unable
to predict whether it will be able to profitably commercialize its product candidates.

 

The Company has not received regulatory
approval for the sale of MDNA55 in any market. Accordingly, the Company has not generated any revenues from product sales. A substantial
commitment of resources to conduct clinical trials and for additional product development will be required to commercialize all
of our product candidates. There can be no assurance that MDNA55, the MDNA109 platform (MDNA19 and MDNA11) or any of our other
product candidates will meet applicable regulatory standards, be capable of being produced in commercial quantities at reasonable
cost or be successfully marketed, or that the investment made by the Company in the commercialization of the products will be recovered
through sales, license fees or related royalties.

 

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The Company will be subject to extensive
government regulation that will increase the cost and uncertainty associated with gaining final regulatory approval of its product
candidates.

 

Securing final regulatory approval for
the manufacture and sale of human therapeutic products in the United States, Canada and other markets is a long and costly process
that is controlled by that particular country’s national regulatory agency. Approval in the United States, Canada or Europe
does not assure approval by other national regulatory agencies, although often test results from one country may be used in applications
for regulatory approval in another country. Other national regulatory agencies have similar regulatory approval processes, but
each is different.

 

Prior to obtaining final regulatory approval
to market a drug product, every national regulatory agency has a variety of statutes and regulations which govern the principal
development activities. These laws require controlled research and testing of products, government review and approval of a submission
containing preclinical and clinical data establishing the safety and efficacy of the product for each use sought, approval of manufacturing
facilities including adherence to cGMP during production and storage and control of marketing activities, including advertising
and labelling. There can be no assurance that MDNA55 or the MDNA109 platform (MDNA19 and MDNA11) will be successfully commercialized
in any given country. There can be no assurance that the Company’s licensed products will prove to be safe and effective
in clinical trials under the standards of the regulations in the various jurisdictions or receive applicable regulatory approvals
from applicable regulatory bodies.

 

Negative results from clinical trials
or studies of third parties and adverse safety events involving the targets of the Company’s products may have an adverse
impact on future commercialization efforts.

 

From time to time, studies or clinical
trials on various aspects of biopharmaceutical products are conducted by academic researchers, competitors or others. The results
of these studies or trials, when published, may have a significant effect on the market for the biopharmaceutical product that
is the subject of the study. The publication of negative results of studies or clinical trials or adverse safety events related
to the Company’s product candidates, or the therapeutic areas in which the Company’s product candidates compete, could
adversely affect the share price and ability to finance future development of the Company’s product candidates, and the business
and financial results could be materially and adversely affected.

 

The Company faces the risk of product
liability claims, which could exceed its insurance coverage and produce recalls, each of which could deplete cash resources.

 

The Company is exposed to the risk of product
liability claims alleging that use of its product candidate MDNA55, and in the future, the MDNA109 platform (MDNA19 and MDNA11),
caused an injury or harm. These claims can arise at any point in the development, testing, manufacture, marketing or sale of product
candidates and may be made directly by patients involved in clinical trials of product candidates, by consumers or healthcare providers
or by individuals, organizations or companies selling the products. Product liability claims can be expensive to defend, even if
the product or product candidate did not actually cause the alleged injury or harm.

 

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Insurance covering product liability claims
becomes increasingly expensive as a product candidate moves through the development pipeline to commercialization. Currently the
Company maintains clinical trial liability insurance coverage of $5 million. However, there can be no assurance that such insurance
coverage is or will continue to be adequate or available at a cost acceptable to the Company or at all. The Company may choose
or find it necessary under its collaborative agreements to increase the insurance coverage in the future but may not be able to
secure greater or broader product liability insurance coverage on acceptable terms or at reasonable costs when needed. Any liability
for damages resulting from a product liability claim could exceed the amount of the coverage, require payment of a substantial
monetary award from the Company’s cash resources and have a material adverse effect on the business, financial condition
and results of operations. Moreover, a product recall, if required, could generate substantial negative publicity about the products
and business, inhibit or prevent commercialization of other products and product candidates or negatively impact existing or future
collaborations.

 

Changes in government regulations,
although beyond the Company’s control, could have an adverse effect on the Company’s business.

 

The Company depends upon the validity of
its licenses and access to the data for the timely completion of clinical research. Any changes in the drug development regulatory
environment or shifts in political attitudes of a government are beyond the Company’s control and may adversely affect its
business. The Company’s business may also be affected in varying degrees by such factors as government regulations with respect
to intellectual property, regulation or export controls. Such changes remain beyond the Company’s control and the effect
of any such changes cannot be predicted. These factors could have a material adverse effect on the Company’s ability to further
develop its licensed products.

 

The Company’s significant shareholders
may have material influence over its governance and operations.

 

Dr. Fahar Merchant and Ms. Rosemina
Merchant (collectively, the “Merchants”), hold a signficant interest in the Company’s outstanding Common Shares
on a fully diluted basis. For as long as the Merchants maintain a significant interest in the Company, they may be in a position
to affect the Company’s governance and operations. In addition, the Merchants may have significant influence over the passage
of any resolution of the Company’s shareholders (such as those that would be required to amend the constating documents or
take certain other corporate actions) and may, for all practical purposes, be able to ensure the passage of any such resolution
by voting for it or prevent the passage of any such resolution by voting against it. The effect of this influence may be to limit
the price that investors are willing to pay for the Common Shares. In addition, the potential that the Merchants may sell their
Common Shares in the public market (commonly referred to as “market overhang”), as well as any actual sales of such
Common Shares in the public market, could adversely affect the market price of the Common Shares.

 

If the Company is unable to enroll
subjects in clinical trials, it will be unable to complete these trials on a timely basis.

 

It is anticipated that the COVID-19 pandemic
crisis will impact ongoing trial activities across the industry due to the pressure placed on the healthcare system as well as
governmental and institutional restrictions. The Company is not currently enrolling patients in a clinical study and does not plan
to enrol additional patients until 2021. Should the COVID-19 pandemic continue into 2021 the Company’s will need to determine
at that time if initiating a clinical trial is feasible and if so the clinical team will need to work closely with each clinical
site and a CRO on a plan to ensure that patient safety and the integrity of data is maintained. It is noted that some clinical
sites have paused or slowed enrollment in clinical trials, while other sites, less impacted, are continuing activities as planned.

 

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Patient enrollment, a significant factor
in the timing of clinical trials, is affected by many factors including the size and nature of the patient population, the proximity
of subjects to clinical sites, the eligibility criteria for the trial, the design of the clinical trial, ability to obtain and
maintain patient consents, risk that enrolled subjects will drop out before completion, competing clinical trials and clinicians’
and patients’ perceptions as to the potential advantages of the drug being studied in relation to other available therapies,
including any new drugs that may be approved for the indications the Company is investigating. Furthermore, the Company relies
on CROs and clinical trial sites to ensure the proper and timely conduct of its clinical trials, and while it has agreements governing
their committed activities, the Company has limited influence over their actual performance.

 

If the Company experiences delays in the
completion or termination of any clinical trial of its proposed products or any future product candidates, the commercial prospects
of its product candidates will be harmed and its ability to generate product revenues from any of these product candidates will
be delayed. In addition, any delays in completing clinical trials will increase costs, slow down product candidate development
and approval process and can shorten any periods during which the Company may have the exclusive right to commercialize its product
candidates or allow its competitors to bring products to market before it does. Delays can further jeopardize the Company’s
ability to commence product sales, which will impair its ability to generate revenues and may harm the business, results of operations,
financial condition and cash flows and future prospects. In addition, many of the factors that can cause a delay in the commencement
or completion of clinical trials may also ultimately lead to the denial of regulatory approval of its proposed products or its
future product candidates.

 

The Company’s discovery and
development processes involve use of hazardous and radioactive materials which may result in potential environmental exposure.

 

The Company’s discovery and development
processes involve the controlled use of hazardous and radioactive materials. The Company is subject to federal, provincial, state
and local laws and regulations governing the use, manufacture, storage, handling and disposal of such materials and certain waste
products. Although the Company believes that the current safety procedures for handling and disposing of such materials comply
with the standards prescribed by such laws and regulations, the risk of accidental contamination or injury from these materials
cannot be completely eliminated. In the event of such an accident, the Company could be held liable for any damages that result
and any such liability could exceed the Company’s resources. The Company is not specifically insured with respect to this
liability. Although the Company believes that the Company is in compliance in all material respects with applicable environmental
laws and regulations and currently does not expect to make material capital expenditures for environmental control facilities in
the near term, there can be no assurance that the Company will not be required to incur significant costs to comply with environmental
laws and regulations in the future, or that the operations, business or assets will not be materially adversely affected by current
or future environmental laws or regulations.

 

    45

     

    

 

If the Company is unable to successfully
develop companion diagnostics for its therapeutic product candidates, or experience significant delays in doing so, the Company
may not achieve marketing approval or realize the full commercial potential of its therapeutic product candidates.

 

The Company plans to develop companion
diagnostics for its therapeutic product candidates. It is expected that, at least in some cases, regulatory authorities may require
the development and regulatory approval of a companion diagnostic as a condition to approving a therapeutic product candidate.
The Company has limited experience and capabilities in developing or commercializing diagnostics and plans to rely in large part
on third parties to perform these functions. The Company does not currently have any agreement in place with any third party to
develop or commercialize companion diagnostics for any of its therapeutic product candidates.

 

Companion diagnostics are subject to regulation
by the FDA, Health Canada and comparable foreign regulatory authorities as medical devices and may require separate regulatory
approval or clearance prior to commercialization. If the Company, or any third parties that the Company engages to assist, are
unable to successfully develop companion diagnostics for the Company’s therapeutic product candidates, or experience delays
in doing so, the Company’s business may be substantially harmed.

 

Significant disruption in availability
of key components for ongoing clinical studies could considerably delay completion of potential clinical trials, product testing
and regulatory approval of potential product candidates.

 

The Company relies on third parties to
supply ingredients and excipients for the manufacture and formulation of its drugs, catheters required to deliver the drug to the
brain as well as imaging software to accurately place catheters in the tumor (“Components”). Each of the suppliers
of these Components in turn need to comply with regulatory requirements. Any significant disruption in supplier relationships could
harm the Company’s business, including the potential impact of COVID-19. Any significant delay in the supply of a Component,
for a potential ongoing clinical study could considerably delay completion of potential clinical trials, product testing and regulatory
approval of potential product candidates. If the Company or its suppliers are unable to purchase these Components after regulatory
approval has been obtained for the product candidates, or the suppliers decide not to manufacture these Components or provide support
for any of the Components, clinical trials or the commercial launch of that product candidate would be delayed or there would be
a shortage in supply, which would impair the ability to generate revenues from the sale of the product candidates. It may take
several years to establish an alternative source of supply for such Components and to have any such new source approved by the
FDA and other regulatory agencies.

 

Risks Related to Intellectual Property and Litigation

 

The Company’s success depends
upon its ability to protect its intellectual property and its proprietary technology.

 

The Company’s success depends, in
part, on its ability and its licensors’ ability to obtain patents, maintain trade secrets protection and operate without
infringing on the proprietary rights of third parties or having third parties circumvent its rights. Certain licensors and the
institutions that they represent, and in certain cases, have filed and are actively pursuing certain applications for Canadian
and foreign patents. The patent position of pharmaceutical and biotechnology firms is uncertain and involves complex legal and
financial questions for which, in some cases, certain important legal principles remain unresolved. There can be no assurance that
the patent applications made in respect of the owned or licensed products will result in the issuance of patents, that the term
of a patent will be extendable after it expires in due course, that the licensors or the institutions that they represent will
develop additional proprietary products that are patentable, that any patent issued to the licensors or the Company will provide
it with any competitive advantages, that the patents of others will not impede its ability to do business or that third parties
will not be able to circumvent or successfully challenge the patents obtained in respect of the licensed products. The cost of
obtaining and maintaining patents is high. Furthermore, there can be no assurance that others will not independently develop similar
products which duplicate any of the licensed products or, if patents are issued, design around the patent for the product. There
can be no assurance that the Company’s processes or products or those of its licensors do not or will not infringe upon the
patents of third parties or that the scope of its patents or those of its licensors will successfully prevent third parties from
developing similar and competitive products.

 

    46

     

    

 

Much of the Company’s know-how and
technology may not be patentable, though it may constitute trade secrets. There can be no assurance, however, that the Company
will be able to meaningfully protect its trade secrets. To help protect its intellectual property rights and proprietary technology,
the Company requires employees, consultants, advisors and collaborators to enter into confidentiality agreements. There can be
no assurance that these agreements will provide meaningful protection for its intellectual property rights or other proprietary
information in the event of any unauthorized use or disclosure.

 

The Company’s potential involvement
in intellectual property litigation could negatively affect its business.

 

Its future success and competitive position
depends in part upon its ability to maintain the its intellectual property portfolio. There can be no assurance that any patents
will be issued on any existing or future patent applications. Even if such patents are issued, there can be no assurance that any
patents issued or licensed to the Company will not be challenged. The Company’s ability to establish and maintain a competitive
position may be achieved in part by prosecuting claims against others who it believes are infringing its rights and by defending
claims brought by others who believe that the Company is infringing their rights. In addition, enforcement of its patents in foreign
jurisdictions will depend on the legal procedures in those jurisdictions. Even if such claims are found to be invalid, the Company’s
involvement in intellectual property litigation could have a material adverse effect on its ability to out-license any products
that are the subject of such litigation. In addition, its involvement in intellectual property litigation could result in significant
expense, which could materially adversely affect the use or licensing of related intellectual property and divert the efforts of
its valuable technical and management personnel from their principal responsibilities, whether or not such litigation is resolved
in its favour.

 

The Company’s reliance on third
parties requires it to share its trade secrets, which increases the possibility that a competitor will discover them.

 

Because the Company relies on third parties
to develop its products, it must share trade secrets with them. The Company seeks to protect its proprietary technology in part
by entering into confidentiality agreements and, if applicable, material transfer agreements, collaborative research agreements,
consulting agreements or other similar agreements with its collaborators, advisors, employees and consultants prior to beginning
research or disclosing proprietary information. These agreements typically restrict the ability of the Company’s collaborators,
advisors, employees and consultants to publish data potentially relating to the Company’s trade secrets. The Company’s
academic collaborators typically have rights to publish data, provided that the Company is notified in advance and may delay publication
for a specified time in order to secure its intellectual property rights arising from the collaboration. In other cases, publication
rights are controlled exclusively by the Company, although in some cases it may share these rights with other parties. The Company
also conducts joint research and development programs which may require it to share trade secrets under the terms of research and
development collaboration or similar agreements. Despite the Company’s efforts to protect its trade secrets, its competitors
may discover its trade secrets, either through breach of these agreements, independent development or publication of information
including its trade secrets in cases where the Company does not have proprietary or otherwise protected rights at the time of publication.
A competitor’s discovery of the Company’s trade secrets may impair its competitive position and could have a material
adverse effect on its business and financial condition.

 

    47

     

    

 

Product liability claims are an inherent
risk of the Company’s business, and if the Company’s clinical trial and product liability insurance prove inadequate,
product liability claims may harm its business.

 

Human therapeutic products involve an inherent
risk of product liability claims and associated adverse publicity. There can be no assurance that the Company will be able to obtain
or maintain product liability insurance on acceptable terms or with adequate coverage against potential liabilities. Such insurance
is expensive, difficult to obtain and may not be available in the future on acceptable terms, or at all. An inability to obtain
sufficient insurance coverage on reasonable terms or to otherwise protect against potential product liability claims could have
a material adverse effect on the Company’s business by preventing or inhibiting the commercialization of its products, licensed
and owned, if a product is withdrawn or a product liability claim is brought against the Company.

 

Generally, a litigation risk exists
for any company that may compromise its ability to conduct the Company’s business.

 

All industries are subject to legal claims,
with and without merit. Defense and settlement costs can be substantial, even with respect to claims that have no merit. Due to
the inherent uncertainty of the litigation process, the resolution of any particular legal proceeding could have a material adverse
effect on the Company’s business, prospects, financial condition and results of operations.

 

Other Risks

 

Our Common Share price has been volatile in recent years,
and may continue to be volatile.

 

The market prices for securities of biotechnology
companies, including ours, have historically been volatile. In the year ended March 31, 2020, our Common Shares traded on
the TSX at a high of $4.86 and a low of $0.64 per share. A number of factors could influence the volatility in the trading price
of our Common Shares, including changes in the economy or in the financial markets, industry related developments, the results
of product development and commercialization, changes in government regulations, and developments concerning proprietary rights,
litigation and cash flow. Our quarterly losses may vary because of the timing of costs for clinical trials, manufacturing and preclinical
studies. Also, the reporting of clinical data or the lack thereof, adverse safety events involving our products and public rumors
about such events could cause our share price to decline or experience periods of volatility. Each of these factors could lead
to increased volatility in the market price of our Common Shares. In addition, changes in the market prices of the securities of
our competitors may also lead to fluctuations in the trading price of our Common Shares.

 

    48

     

    

 

Future sales or issuances of equity
securities or the conversion of securities into Common Shares could decrease the value of the Common Shares, dilute investors’
voting power, and reduce earnings per share.

 

The Company may sell additional equity
securities in future offerings, including through the sale of securities convertible into equity securities, to finance operations,
acquisitions or projects, and issue additional Common Shares if outstanding securities are converted into Common Shares, which
may result in dilution.

 

The Company’s board of directors
will have the authority to authorize certain offers and sales of additional securities without the vote of, or prior notice to,
shareholders. Based on the need for additional capital to fund expected expenditures and growth, it is likely that the Company
will issue additional securities to provide such capital.

 

Sales of substantial amounts of securities,
or the availability of such securities for sale, as well as the issuance of substantial amounts of Common Shares upon conversion
or exchange of outstanding convertible or exchangeable securities, could adversely affect the prevailing market prices for securities
and dilute investors’ earnings per share. A decline in the future market prices of the Company’s securities could impair
its ability to raise additional capital through the sale of securities should it desire to do so.

 

In the past, following periods of volatility
in the market price of a company’s securities, shareholders have instituted class action securities litigation against those
companies. Such litigation, if instituted, could result in substantial costs and diversion of management attention and resources,
which could significantly harm the Company’s profitability and reputation.

 

The market price for the Common Shares
may also be affected by the Company’s ability to meet or exceed expectations of analysts or investors. Any failure to meet
these expectations, even if minor, may have a material adverse effect on the market price of the Common Shares.

 

The Company is subject to foreign
exchange risk relating to the relative value of the United States dollar.

 

A material portion of the Company’s
expenses are denominated in United States dollars. As a result, the Company is subject to foreign exchange risks relating to the
relative value of the Canadian dollar as compared to the United States dollar. A decline in the Canadian dollar would result in
an increase in the actual amount of its expenses and adversely impact financial performance.

 

The Company’s disclosure controls
and procedures may not prevent or detect all errors or acts of fraud.

 

The Company’s disclosure controls
and procedures are designed to reasonably assure that information required to be disclosed by the Company in reports it files or
submits under applicable securities laws is accumulated and communicated to management, recorded, processed, summarized and reported
within the time periods specified under applicable securities laws. The Company believes that any disclosure controls and procedures
or internal controls and procedures, no matter how well conceived and operated, can provide only reasonable, not absolute, assurance
that the objectives of the control system are met. These inherent limitations include the realities that judgments in decision-making
can be faulty, and that breakdowns can occur because of simple error or mistake. Additionally, controls can be circumvented by
the individual acts of some persons, by collusion of two or more people or by an unauthorized override of the controls. Accordingly,
because of the inherent limitations in the Company’s control system, misstatements or insufficient disclosures due to error
or fraud may occur and not be detected.

 

    49

     

    

 

Any failure to maintain an effective
system of internal controls may result in material misstatements of the Company’s consolidated financial statements or cause
the Company to fail to meet the reporting obligations or fail to prevent fraud; and in that case, shareholders could lose confidence
in the Company’s financial reporting, which would harm the business and could negatively impact the price of the Common Shares.

 

Effective internal controls are necessary
to provide reliable financial reports and prevent fraud. If there is a failure to maintain an effective system of internal controls,
the Company might not be able to report financial results accurately or prevent fraud; and in that case, shareholders could lose
confidence in the Company’s financial reporting, which would harm the business and could negatively impact the price of the
Common Shares. While the Company believes that it will have sufficient personnel and review procedures to maintain an effective
system of internal controls, no assurance can be provided that potential material weaknesses in internal control could arise. Even
if it is concluded that the internal control over financial reporting provides reasonable assurance regarding the reliability of
financial reporting and the preparation of consolidated financial statements for external purposes in accordance with IFRS, as
issued by the International Accounting Standards Board (IASB), because of its inherent limitations, internal control over financial
reporting may not prevent or detect fraud or misstatements. Failure to implement required new or improved controls, or difficulties
encountered in their implementation, could harm results of operations or cause a failure to meet future reporting obligations.

 

Failure to comply with the U.S. Foreign
Corrupt Practices Act (“FCPA”), the Canadian Corruption of Foreign Public Officials Act (“CFPOA”), and
other global anti-corruption and anti-bribery laws could subject the Company to penalties and other adverse consequences.

 

The FCPA and the CFPOA, as well as any
other applicable domestic or foreign anti-corruption or anti-bribery laws to which the Company is or may become subject generally
prohibit corporations and individuals from engaging in certain activities to obtain or retain business or to influence a person
working in an official capacity and requires companies to maintain accurate books and records and internal controls, including
at foreign-controlled subsidiaries.

 

Compliance with these anti-corruption laws
and anti-bribery laws may be expensive and difficult, particularly in countries in which corruption is a recognized problem. In
addition, these laws present particular challenges in the pharmaceutical industry, because, in many countries, hospitals are operated
by the government, and physicians and other hospital employees are considered to be foreign officials. Certain payments by other
companies to hospitals in connection with clinical trials and other work have been deemed to be improper payments to governmental
officials and have led to FCPA enforcement actions.

 

The Company’s internal control policies
and procedures may not protect it from reckless or negligent acts committed by the Company’s employees, future distributors,
licensees or agents. The Company can make no assurance that they will not engage in prohibited conduct, and the Company may be
held liable for their acts under applicable anti-corruption and anti-bribery laws. Noncompliance with these laws could subject
the Company to investigations, sanctions, settlements, prosecution, other enforcement actions, disgorgement of profits, significant
fines, damages, other civil and criminal penalties or injunctions, suspension or debarment from contracting with certain persons,
the loss of export privileges, whistleblower complaints, reputational harm, adverse media coverage, and other collateral consequences.
Any investigations, actions or sanctions or other previously mentioned harm could have a material negative effect on the Company’s
business, operating results and financial condition.

 

    50

     

    

 

Any future profits will likely be
used for the continued growth of the business and products and will not be used to pay dividends on the issued and outstanding
shares.

 

The Company will not pay dividends on the
issued and outstanding Common Shares in the foreseeable future. If the Company generates any future earnings, such cash resources
will be retained to finance further growth and current operations. The board of directors will determine if and when dividends
should be declared and paid in the future based on the Company’s financial position and other factors relevant at the particular
time. Until the Company pays dividends, which it may never do, a shareholder will not be able to receive a return on his or her
investment in the Common Shares unless such Common Shares are sold. In such event, a shareholder may only be able to sell his,
her or its Common Shares at a price less than the price such shareholder originally paid for them, which could result in a significant
loss of such shareholder’s investment.

 

The Company may pursue other business
opportunities in order to develop its business and/or products.

 

From time to time, the Company may pursue
opportunities for further research and development of other products. The Company’s success in these activities will depend
on its ability to identify suitable technical experts, market needs, and effectively execute any such research and development
opportunities. Any research and development would be accompanied by risks as a result of the use of business efforts and funds.
In the event that the Company chooses to raise debt capital to finance any such research or development opportunities, its leverage
will be increased. There can be no assurance that the Company would be successful in overcoming these risks or any other problems
encountered in connection with any research or development opportunities.

 

The Company may acquire businesses
or products, or form strategic alliances, in the future, and the Company may not realize the benefits of such acquisitions.

 

The Company may acquire additional businesses
or products, form strategic alliances or create joint ventures with third parties that the Company believes will complement or
augment its existing business. If the Company acquires businesses with promising products or technologies, the Company may not
be able to realize the benefit of acquiring such businesses if the Company is unable to successfully integrate them with its existing
operations and company culture. The Company may encounter numerous difficulties in developing, manufacturing and marketing any
new products resulting from a strategic alliance or acquisition that delay or prevent it from realizing their expected benefits
or enhancing the Company’s business. The Company cannot assure investors that, following any such acquisition, it will achieve
the expected synergies to justify the transaction.

 

    51

     

    

 

The Company’s success depends
on its ability to effectively manage its growth.

 

The Company may be subject to growth-related
risks including pressure on its internal systems and controls. The Company’s ability to manage its growth effectively will
require the Company to continue to implement and improve its operational and financial systems and to expand, train and manage
its employee base. Inability to deal with this growth could have a material adverse impact on its business, operations and prospects.
The Company may experience growth in the number of its employees and the scope of its operating and financial systems, resulting
in increased responsibilities for its personnel, the hiring of additional personnel and, in general, higher levels of operating
expenses. In order to manage its current operations and any future growth effectively, the Company will also need to continue to
implement and improve its operational, financial and management information systems and to hire, train, motivate, manage and retain
its employees. There can be no assurance that the Company will be able to manage such growth effectively, that its management,
personnel or systems will be adequate to support its operations or that the Company will be able to achieve the increased levels
of revenue commensurate with the increased levels of operating expenses associated with this growth.

 

If the Company is treated as a passive
foreign investment company, United States shareholders may be subject to adverse U.S. federal income tax consequences

 

Under the U.S. Internal Revenue Code of
1986, as amended (the “Code”), the Company will be classified as a passive foreign investment company (“PFIC”)
in respect of any taxable year in which either (i) 75% or more of its gross income consists of certain types of “passive
income” or (ii) 50% or more of the average quarterly value of its assets is attributable to “passive assets”
(assets that produce or are held for the production of passive income). For purposes of these tests, passive income includes dividends,
interest, gains from the sale or exchange of investment property and certain rents and royalties. In addition, for purposes of
the above calculations, if the Company directly or indirectly owns at least 25% by value of the shares of another corporation,
the Corporation will be treated as if it held its proportionate share of the assets and received directly its proportionate share
of the income of such other corporation. PFIC status is a factual determination that needs to be made annually after the close
of each taxable year, on the basis of the composition of the Company’s income, the relative value of its active and passive
assets, and its market capitalization. For this purpose, the Company’s PFIC status depends in part on the application of
complex rules, which may be subject to differing interpretations, relating to the classification of the Company’s income
and assets. Based on our interpretation of the law, the Company’s recent financial statements, and considering expectations
about the Company’s income, assets and activities, the Company believes that it was a PFIC for the taxable year ended March 31,
2020 and expects that it will be a PFIC for the current taxable year.

 

If the Company is a PFIC for any taxable
year during which a United States shareholder holds the Common Shares, the Company will continue to be treated as a PFIC with respect
to such United States shareholder in all succeeding years during which the United States shareholder owns the Common Shares, regardless
of whether the Company continues to meet the PFIC test described above, unless the United States shareholder makes a specified
election once the Company ceases to be a PFIC. If the Company is classified as a PFIC for any taxable year during which a United
States shareholder holds the Common Shares, the United States shareholder may be subject to adverse tax consequences regardless
of whether the Company continues to qualify as a PFIC, including ineligibility for any preferred tax rates on capital gains or
on actual or deemed dividends, interest charges on certain taxes treated as deferred, and additional reporting requirements. In
certain circumstances, a United States shareholder may alleviate some of the adverse tax consequences attributable to PFIC status
by making either a “qualified electing fund,” (“QEF”) election or a mark-to-market election (if the Common
Shares constitute “marketable” securities under the Code). If the Company determines that it is a PFIC for this year
or any future taxable year, the Company currently expects that it would provide the information necessary for United States shareholders
to make a QEF election.

 

    52

     

    

 

Each United States shareholder should consult
its own tax advisors regarding the PFIC rules and the United States federal income tax consequences of the acquisition, ownership
and disposition of the Common Shares.

 

The Company’s operations could
be adversely affected by events outside of its control, such as natural disasters, wars or health epidemics

 

The Company may be impacted by business
interruptions resulting from pandemics and public health emergencies, including those related to COVID-19 coronavirus, geopolitical
actions, including war and terrorism or natural disasters including earthquakes, typhoons, floods and fires. An outbreak of infectious
disease, a pandemic or a similar public health threat, such as the recent outbreak of the novel coronavirus known as COVID-19,
or a fear of any of the foregoing, could adversely impact the Company by causing operating, manufacturing supply chain, clinical
trial and project development delays and disruptions, labour shortages, travel and shipping disruption and shutdowns (including
as a result of government regulation and prevention measures). It is unknown whether and how the Company may be affected if such
an epidemic persists for an extended period of time. The Company may incur expenses or delays relating to such events outside of
its control, which could have a material adverse impact on its business, operating results and financial condition.

 

It may be difficult for non-Canadian
investors to obtain and enforce judgments against the Company because of the Company’s Canadian incorporation and presence.

 

The Company is a corporation existing under
the federal laws of Canada. Most of the Company’s directors and officers, and several of the experts, are residents of Canada,
and all or a substantial portion of their assets, and a substantial portion of the Company’s assets, are located outside
the United States. Consequently, it may be difficult for holders of the Company’s securities who reside in the United States
to effect service of process within the United States upon those directors, officers and experts who are not residents of the United
States. It may also be difficult for holders of the Company’s securities who reside in the United States to realize in the
United States upon judgments of courts of the United States predicated upon the Company’s civil liability and the civil liability
of the Company’s directors, officers and experts under the United States federal securities laws. Investors should not assume
that Canadian courts (i) would enforce judgments of United States courts obtained in actions against the Company or such directors,
officers or experts predicated upon the civil liability provisions of the United States federal securities laws or the securities
or “blue sky” laws of any state or jurisdiction of the United States or (ii) would enforce, in original actions,
liabilities against the Company or such directors, officers or experts predicated upon the United States federal securities laws
or any securities or “blue sky” laws of any state or jurisdiction of the United States. In addition, the protections
afforded by Canadian securities laws may not be available to investors in the United States.

 

The Company may lose foreign private
issuer status in the future, which could result in significant additional costs and expenses.

 

The Company may in the future lose foreign
private issuer status if a majority of the Common Shares are held in the United States and the Company fails to meet the additional
requirements necessary to avoid loss of foreign private issuer status, such as if: (i) a majority of the Company’s directors
or executive officers are U.S. citizens or residents; (ii) a majority of the Company’s assets are located in the United
States; or (iii) the Company’s business is administered principally in the United States. The regulatory and compliance
costs to the Company under U.S. securities laws as a U.S. domestic issuer may be significantly more than the costs incurred as
a foreign private issuer.

 

    53

     

    

 

DIVIDENDS

 

There are no restrictions in the Company’s
articles preventing the Company from paying dividends. The Company has not declared or paid any dividends since incorporation.
The directors of the Company anticipate that the Company will retain all future earnings and other cash resources for the future
operation and development of its business, and accordingly, do not intend to declare or pay any cash dividends in the foreseeable
future. Payment of any future dividends will be at the discretion of the board of the directors after taking into account many
factors including the Company’s operating results, financial condition and current and anticipated cash assets.

 

SHARE
CAPITAL

 

Common Shares

 

The authorized share capital of the Company
consists of an unlimited number of Common Shares of which 48,500,376 Common Shares are issued and outstanding as fully paid and
non-assessable as at the date hereof.

 

Each Common Share carries one vote at all
meetings of shareholders, is entitled to receive dividends as and when declared by the directors, and is entitled to a pro-rata
share of the remaining property and assets of the Company distributable to the holders of the Common Shares upon any liquidation,
dissolution or winding-up of the Company.

 

Convertible Securities

 

In addition, as at the date hereof, there
are issued and outstanding the following convertible securities of the Company, details of which are outlined in the table below:

 

	Security	Number	Exercise or

 Conversion Price	
        Expiry Date

(dd/mm/yyyy)

	Stock options	4,130,000	$1.00 to $2.88	24/02/2024 to 08/11/2029
	Warrants	1,468,000	$1.20	21/12/2023
	Warrants	1,953,532	$1.75	17/10/2022
	Broker warrants	163,000	$2.00	05/05/2021
	Broker warrants	57,500	$1.20	20/12/2020
	Broker warrants	209,003	$1.75	17/10/2021
	Broker warrants	845,646	$3.10	17/03/2022
	Incentive warrants	2,667,083	$2.00	01/01/2022 to 01/03/2021

 

    54

     

    

 

 

MARKET
FOR SECURITIES

 

Trading Price and Volume

 

The Common Shares are listed on the TSX
under the symbol “MDNA”. The following table shows the price ranges and volumes traded on the TSX for the periods noted:

 

	Month	TSX
	High ($)	Low ($)	Volume (#)
	April 2019	$0.85	$0.64	434,380
	May 2019	$0.96	$0.66	739,698
	June 2019	$2.38	$0.82	2,205,187
	July 2019	$1.61	$1.02	936,043
	August 2019	$1.43	$1.06	308,067
	September 2019	$1.88	$0.94	799,169
	October 2019	$1.48	$1.10	785,221
	November 2019	$2.05	$1.27	2,702,400
	December 2019	$3.87	$1.30	3,524,777
	January 2020	$3.78	$2.41	3,596,527
	February 2020	$4.86	$2.77	2,365,899
	March 2020	 $4.12 	 $2.15 	5,105,194 

 

Prior Sales

 

The following securities of the Company
(other than Common Shares) were issued during the fiscal year ended March 31, 2020:

 

	Date of Issue	Security	Number	Exercise Price
	June 7, 2019	Stock options	200,000	$1.38
	October 17, 2019	Warrants	2,653,846	$1.75
	October 17, 2019	Broker warrants	350,134	$1.30
	November 18, 2019	Stock options	1,030,000	$1.30
	March 17, 2020	Broker warrants	456,016	$3.10

 

BOARD
OF DIRECTORS AND MANAGEMENT

 

The following are the names and municipalities
of residence of each of the directors and officers of the Company, the positions and offices held with the Company, their respective
principal occupations within the five preceding years and the number and percentage of Common Shares beneficially held by each
of them as of the date hereof. Each director will hold office until the next annual meeting of the Company, unless his or her office
is earlier vacated in accordance with the CBCA or the by-laws of the Company.

 

    55

     

    

 

	Name, State/

                                                                                Province and

                                                                                Country of

                                                                                Residence
	Positions with

                                                                                the Company

                                                                                and, if Director,

                                                                                Date First

                                                                                Elected
	Principal Occupation(s) for Past 5

                                                                                Years
	Number and

                                                                                Percentage of

                                                                                Common Shares

                                                                                Owned(1)

	Fahar

                                               Merchant
 Toronto,

                                               Ontario,

                                               Canada
	
        President, Chief

        Executive Officer

        and Director

        October 30,

        2011(6)
	President and Chief Executive Officer of

                                               Medicenna
	5,250,000(5)

(10.82%)
	Albert Beraldo
 Toronto,

                                               Ontario,

                                               Canada
	
        Director(2)(4)

        November 22,

        2016(6)
	President of Idoman Ltd. (July 2008 to

                                               present)
	
        225,000

        (0.09%)

	
        Karen Dawes

        Palm Beach

        Gardens,

        Florida,

        United States
	
        Director(2)(4)

        September 24,

        2019
	President, Knowledgeable Decisions,

                                               LLC (2003 to present)
	
        25,000

        (0.05%)

	
        Chandrakant

        Panchal

        Dollard-des-

        Ormeaux,

        Quebec,

        Canada
	
        Director(2)(3)

        November 22,

        2016(6)
	
        Chairman, CEO and CSO of Axcelon

        Biopolymers Corp. (2001 to
        present)

         
	
        1,500

        (0.00%)

	Andrew

                                               Strong
 Houston,

                                               Texas,
 United States
	
        Director(3)(4)

        November 22,

        2016(6)
	
        Partner, Pillsbury Winthorp Shaw Pittman

        LLP (March 2015
        to present)

        President and CEO of Kalon

        Biotherapeutics LLC (June 2011
        to

        March 2015)
	
        50,000

        (0.10%)

	
        Rosemina

        Merchant

        Toronto,

        Ontario,

        Canada
	
        Chief

        Development

        Officer and

        Director

        April 25, 2016(6)
	Chief Development Officer of Medicenna

                                               (October 30, 2011 to present)
	5,250,000(5)

(10.82%)
	Elizabeth

                                               Williams
 Georgetown,

                                               Ontario,

                                               Canada
	
        Chief Financial

        Officer,

        Corporate Secretary

        
	
        Chief Financial Officer of Medicenna

        (December 2016 to present)
	5,300

(0.00%)

 

    56

     

    

 

Notes:

 

		(1)	Based on 48,500,376 Common Shares outstanding as of the date hereof.

		(2)	Member of the Company’s Audit Committee.

		(3)	Member of the Company’s Corporate Governance and Nominating Committee.

		(4)	Member of the Company’s Compensation Committee.

		(5)	In addition, an aggregate of 5,500,000 Common Shares (representing 11.34% of the outstanding Common
Shares) are held by Aries Biologics Inc. Fahar Merchant and Rosemina Merchant each own 50% of the voting shares, and are a director
and officer, of Aries Biologics Inc.

		(6)	Represents the date the individual was first appointed
as director of MTI. Each such director was appointed as director of the Company effective March 1, 2017 in connection with
the completion of the Transaction.

 

Biographies of Executive
Officers and Directors

 

Fahar Merchant – Chairman,
President and CEO – Dr. Merchant is a biotech veteran with more than 30 years’ experience, a serial entrepreneur
and co-founder of Medicenna. Previously he was President and CEO of Protox Therapeutics Inc. (TSXV and TSX; now Sophiris, Nasdaq)
where he established a late clinical stage urology company. At Protox Therapeutics Inc. he raised over $70 million through multiple
PIPEs, including a $35 million investment by Warburg Pincus. In 1992, he co-founded IntelliGene Expressions, Inc., a biologics
CDMO, and built it to one of the fastest growing companies in Canada. In 2000, by strategic in-licensing, he co-founded Avicenna
Medica, Inc., a clinical stage oncology company that was sold a year later to KS Biomedix (LSE) for $90 million. Fahar was
CTO and Director of KS Biomedix until its acquisition by Xenova (Nasdaq and LSE; now Celtic Pharma). Fahar has closed several transactions
valued at over $300 million. He has a PhD in Biochemical Engineering from Western University.

 

Albert Beraldo – Director
 – Mr. Beraldo, CPA, CA, has over 30 years’ experience in varying roles within the pharmaceutical/biotechnology
industry. Mr. Beraldo has been the President of Idoman Limited since July 2008, a company dedicated to improving the
lives of women through the manufacture and distribution of innovative, minimally invasive medical solutions. Mr. Beraldo
was the founder and President and Chief Executive Officer of Alveda Pharmaceuticals Inc., a leading supplier of pharmaceuticals
to the Canadian health care market, from 2006 until November 2015. Alveda was acquired by Teligent, Inc. (formerly IGI
Laboratories, Inc., Nasdaq), a New Jersey-based specialty generic pharmaceutical company. Mr. Beraldo formerly served
as President and CEO of Bioniche Pharma Group Limited until 2006. Mr. Beraldo sits on the board of Pure Global Cannabis Inc.
(TSXV) and has served as an Independent Director of Helix Biopharma Corp. (January 2016 to July 2017) and was an Independent
Director of Telesta Therapeutics Inc. (July 2011 to February 2014). Mr. Beraldo worked in public accounting with
Ernst and Whinney until he joined Vetrepharm Canada Inc. as Financial Controller in 1983. Mr. Beraldo obtained a Bachelor
of Commerce degree from the University of Windsor and a Chartered Accountant designation from the Canadian Institute of Chartered
Accountants.

 

Karen A. Dawes – Director
 – With 20+ years of commercial and executive management Ms. Dawes has been a key player in the successful development,
launch and marketing of products in the Cardiovascular, CNS, Oncology, Metabolic, Infectious Disease and Women’s and
Men’s Health areas, including five blockbuster therapeutics. Karen’s industry experience began with 10 years of commercial
and executive management at Pfizer, where she gained increasing responsibility in product management, development, and strategy
leading to her position as Vice-President, Marketing, Pratt Division. Karen then moved to biotech pioneer Genetics Institute (GI),
where, as Chief Commercial Officer, she built the company’s initial commercial operations including strategic and operational
marketing, sales, medical affairs, public relations, and market research. When GI was acquired by Wyeth, Karen was appointed
by the new parent company as Senior Vice-President, Global Strategic Marketing. Subsequently, Karen moved to Bayer Corporation
as Division Head for the company’s U.S. Pharmaceuticals Division. Ms. Dawes is currently President of Knowledgeable
Decisions, a biopharmaceutical consulting firm focusing on corporate and commercial strategy. Ms. Dawes
also serves as the chairperson of the board of directors of RepliGen (NASDAQ: RGEN) and is a member of the board of directors of
Assertio Therapeutics, Inc. (NASDAQ: ASRT) and Medicines360. Karen has a combined B.A and M.A from Simmons College
and an MBA from Harvard Business School.

 

    57

     

    

 

Chandrakant Panchal –
Lead Independent Director – Dr. Panchal is the Founder of Axcelon Biopolymers Corp., a biotechnology company where he
is Chairman, CEO and CSO. From 1989 to 1999 he was Co-Founder, President, and CEO of Procyon Biopharma Inc., which he took public
on the TSXV in 1998 and later on the TSX in 2000. Thereafter, Dr. Panchal was CSO at Procyon until its merger with Cellpep, Inc
(2006). He was then Senior Executive VP of Business Development at the merged entity, Ambrilia Biopharma Inc. During his term at
Procyon and Ambrilia, he led several licensing and M&A transactions with pharmaceutical and biotechnology companies relating
to cancer and HIV drugs developed by the company. Dr. Panchal sits on the boards of Pure Global Cannabis Inc. (as Chairman)
(TSXV:PURE), Canadian Oil Recovery & Remediation Enterprises (TSXV:CVR), Avicanna Inc.(as Lead Director) (TSX:AVCN) and
was until recently, a board member of MaRS Innovation and Avivagen (TSXV:VIV). Dr. Panchal obtained a PhD in biochemical engineering
from Western University.

 

Andrew Strong – Director
- Mr. Strong has been a partner at Pillsbury Winthrop Shaw Pittman since 2015 and leads the Life Sciences Team (Houston, TX).
Mr. Strong represents life sciences companies from early stage biotech start-ups to publicly traded and fully integrated
pharmaceutical companies. From 2009 to 2011,Mr. Strong served as the General Counsel and Compliance Officer for the Texas
A&M University System where he led efforts to secure a multi-billion dollar federal contract to serve as a first line of defense
for influenza pandemics and biological threats. As part of that effort, he led the formation of a state-owned biomanufacturing
company (Kalon Biotherapeutics) and was subsequently appointed founding CEO of Kalon that would develop and manufacture
biologics for clinical and commercial supply for pharmaceutical and biotech companies. In addition to raising capital, Mr. Strong
oversaw the successful sale, in 2014, of Kalon to a subsidiary of FUJIFILM Corporation and Mitsubishi Corporation. Mr. Strong
has a J.D., Law from South Texas College of Law. Mr. Strong was a Director and Chair of the Compensation Committee for Braemer
Hotels & Resorts which is listed on the NYSE from November 2013 to May 2017.

 

Rosemina Merchant – Director
and Chief Development Officer – Ms. Merchant has 30 years of experience in the development of biopharmaceuticals.
Most recently, Ms. Merchant was Senior VP of Development and Regulatory Affairs at Sophiris and responsible for development
of PRX302 for prostate cancer and BPH. She transitioned PRX302, a discovery project to a late stage clinical program in less than
6 years. During that time, she executed multiple clinical trials, managed Canadian and United States regulatory filings and
led all CMC related outsourcing activities in the United States and Europe. In 1992, Nina co-founded IntelliGene Expressions, Inc.,
a biologics CDMO, where she was VP of Manufacturing and Chief Operating Officer. Nina also held a variety of senior level positions
at KS Biomedix, Bioniche, GE LifeSciences, Sanofi Pasteur and Alberta Innovates. Her education includes a MESc. in Biochemical
Engineering from Western University.

 

Elizabeth Williams –
Chief Financial Officer – Ms. Williams, CPA, CA has more than 15 years of experience in biotech, working with publicly
listed entities in both Canada and the United States. Ms. Williams has extensive financing experience playing an integral
role in raising more than $150 million in financing by way of public offerings, private placements, rights offerings, at-the-market
facilities, warrant exercises, corporate reorganizations and debt (issuance and redemption). Prior to joining Medicenna, Ms. Williams
was the Vice President of Finance and Administration at Aptose Biosciences Inc. (previously Lorus Therapeutics Inc., TSX and Nasdaq),
a biotechnology company (“Aptose”). While at Aptose, Ms. Williams held several positions including acting as the
Chief Financial Officer during a lengthy transition period and was responsible for a broad range of activities including financings,
financial reporting and regulatory compliance. Prior to joining Aptose, Ms. Williams was an Audit Manager at Ernst &
Young LLP with a focus on publicly listed multinational companies. Ms. Williams is a Chartered Professional Accountant and
Chartered Accountant and received a Bachelor of Business Administration from Wilfrid Laurier University.

 

    58

     

    

 

Shareholdings of Directors and Executive
Officers

 

As at the date hereof, the directors and
executive officers of the Company as a group beneficially own, directly or indirectly, or exercise control or direction over 16,306,800
or approximately 33.6% of the number of issued and outstanding Common Shares.

 

CEASE
TRADE ORDERS, BANKRUPTCIES, PENALTIES OR SANCTIONS

 

Cease Trade Orders

 

To the knowledge of the Company, no director
or executive officer of the Company is, or within the ten years prior to the date hereof has been, a director, chief executive
officer, or chief financial officer, of any company (including the Company) that was subject to (a) a cease trade order; (b) an
order similar to a cease trade order; or (c) an order that denied the relevant company access to any exemption under securities
laws, that was in effect for a period of more than thirty consecutive days, issued while that person was acting in such capacity
or issued thereafter but resulted from an event that occurred while that person was acting in such capacity.

 

Bankruptcies

 

To the knowledge of the Company, no director
or executive officer or shareholder holding a sufficient number of securities of the Company to affect materially the control of
the Company is, or within the ten years prior to the date hereof has been, a director or executive officer of any company (including
the Company) that, while that person was acting in such capacity or within a year of that person ceasing to act in such capacity,
became bankrupt, made a proposal under any legislation relating to bankruptcy or insolvency or was subject to or instituted any
proceedings, arrangement or compromise with creditors or had a receiver, receiver manager or trustee appointed to hold its assets.

 

To the knowledge of the Company, no director
or executive officer or shareholder holding a sufficient number of securities of the Company to affect materially the control of
the Company has, within the ten years prior to the date hereof, become bankrupt, made a proposal under any legislation relating
to bankruptcy or insolvency, or become subject to or instituted any proceedings, arrangement, or compromise with creditors, or
had a receiver, receiver manager or trustee appointed to hold that person’s assets.

 

Penalties and Sanctions

 

No director or executive officer of the
Company, or a shareholder holding a sufficient number of securities of Medicenna to affect materially the control of the Company
has been subject to (a) any penalties or sanctions imposed by a court relating to securities laws or by a securities regulatory
authority or has entered into a settlement agreement with a securities regulatory authority; or (b) any other penalties or
sanctions imposed by a court or regulatory body that would likely be considered important to a reasonable investor in making an
investment decision.

 

    59

     

    

 

All of the above disclosure also applies
to any personal holding companies of any of the persons referred to above.

 

CONFLICTS
OF INTEREST

 

Certain of the Company’s officers
and directors are also officers and/or directors of other, or may otherwise be involved with or consulted by, companies engaged
in the biotechnology industry and research business generally and may be presented from time to time with situations or opportunities
which give rise to apparent conflicts of interest which cannot be resolved by arm’s-length negotiations but only through
exercise by the officers and directors of such judgment as is consistent with their fiduciary duties to the Company which arise
under applicable corporate law, especially insofar as taking advantage, directly or indirectly, of information or opportunities
acquired in their capacities as directors or officers of the Company. Any such conflict is governed by applicable corporate laws,
which require that directors act honestly, in good faith and with a view to the best interests of the Company. It is expected that
any transactions with officers and directors will be on terms consistent with industry standards and sound business practice in
accordance with the fiduciary duties of those persons to the Company, and, depending upon the magnitude of the transactions and
the absence of any disinterested board members, may be submitted to the shareholders for their approval.

 

In addition, the CBCA requires officers
and directors to disclose any personal interest which they may have in any material contract or transaction which is proposed to
be entered into with the Company and, in the case of directors, to abstain from voting as a director for the approval of any such
contract or transaction, unless otherwise permitted under the CBCA.

 

LEGAL
PROCEEDINGS and regulatory actions

 

There are no existing or contemplated material
legal proceedings to which Medicenna or a subsidiary of Medicenna is a party or of which any of their respective property is the
subject matter and no such proceedings known to Medicenna is contemplated. Medicenna has not had any material penalties or sanctions
imposed against it by any legal or regulatory authorities.

 

INTEREST
OF MANAGEMENT AND OTHERS IN MATERIAL TRANSACTIONS

 

Except as otherwise set out herein, there
are no material interests, direct or indirect, of any director, executive officer, person who beneficially owns, or controls or
directs, directly or indirectly, more than 10% of the outstanding Common Shares, or any known associates or affiliates of such
persons, in any transaction within the last three completed financial years or during the current financial year which has materially
affected or is reasonably expected to materially affect the Company.

 

TRANSFER
AGENT

 

The Company’s registrar and transfer
agent is TSX Trust Company, located at 301 – 100 Adelaide St. West, Toronto, Ontario, M5H 4H1.

 

    60

     

    

 

MATERIAL
CONTRACTS

 

The Company is not party to any material
contract that was entered into either (1) in the last completed fiscal year, or (2) before the most recently completed
fiscal year but that is still in effect as of the date hereof, except for contracts entered into in the ordinary course of business
and as set out below:

 

		1.	the warrant indenture dated October 17, 2019 between the Company and TSX Trust Company regarding
the provision for issuance of the unit warrants from the October 2019 public offering;

 

		2.	the warrant indenture dated December 21, 2018 between the Company and TSX Trust Company regarding
the provision for issuance of the unit warrants from the December 2018 public offering;

 

		3.	the license agreements with Stanford made effective as of August 21, 2015, and subsequent
amendments;

 

		4.	the NIH License Agreement and subsequent amendments; and

 

		5.	the CPRIT grant agreement made effective as of March 1, 2015, and subsequent extensions.

 

INTEREST
OF EXPERTS

 

The Company’s registered public accounting
firm is Davidson & Company LLP. Davidson & Company LLP has advised that they are independent with respect to
the Company within the meaning of the Rules of Professional Conduct of the Chartered Professional Accountants of Ontario (registered
name of the Institute of Chartered Accountants of Ontario) and the rules and standards of the Public Company Accounting Oversight
Board (United States) and the securities laws and regulations administered by the United States Securities and Exchange Commission.

 

Except as disclosed herein, no person or
company whose profession or business gives authority to a report, valuation, statement or opinion made by the person or company
and who is named as having prepared or certified the report, valuation, statement or opinion described in or included in this AIF
or a filing made under National Instrument 51-102 by the Company, during, or relating to, the Company’s most recently completed
financial year holds more than 1% beneficial interest, direct or indirect, in any securities or other property of the Company or
of an associate or affiliate of the Company and no such person is expected to be elected, appointed or employed as a director,
senior officer or employee of the Company or of an associate or affiliate of the Company.

 

ADDITIONAL
INFORMATION

 

Additional information about us may be
found on SEDAR at www.sedar.com. Additional information, including directors’ and officers’ remuneration and indebtedness,
principal holders of our securities, options to purchase securities and securities authorized for issuance under equity compensation
plans, is contained in our Management Information Circular for our most recent annual meeting of shareholders. Additional information
may also be found in our audited financial statements and related management’s discussion and analysis for our most recently
completed financial year.

 

    61

     

    

 

Schedule
A

audit committee information

 

		a)	Audit Committee Charter

 

See Appendix 1 attached hereto.

 

		b)	Composition of the Audit Committee

 

The Audit Committee of the Company
is currently comprised of Mr. Alberto Beraldo (Chairman), Dr. Chandrakant Panchal and Ms. Karen Dawes. All members
of the Audit Committee are considered to be independent and financially literate within the meaning of National Instrument 52-110
 – Audit Committees (“NI 52-110”).

 

		c)	Relevant Education and Experience

 

The relevant education and experience
of each member of the Audit Committee is provided above, under the heading “Board of Directors and Management”. All
of the Audit Committee members are independent of management of the Company as required by the TSX and each member is financially
literate in that he or she has the ability to read and understand a set of financial statements that present a breadth and level
of complexity of accounting issues that are generally comparable to the breadth and complexity of the issues that can reasonably
be expected to be raised by the Company’s financial statements. Each individual has experience managing a company as the
President and/or Chief Executive Officer or, in the case of Mr. Beraldo, as both the Chief Executive Officer and Chief Financial
Officer and, in those roles, reviewing financial statements and reports. Mr. Albert Beraldo, Chairman of the Audit Committee,
is the Financial Expert of the Committee and is a CPA, CA with many years of experience as the Chief Financial Officer of both
private and public companies. In addition to their experience as Executive Officers, each member of the Audit Committee has experience
serving on public company boards.

 

		d)	Audit Committee Oversight

 

At no time since the commencement
of the Company’s most recently completed financial period was a recommendation of the Audit Committee to nominate or compensate
an external auditor not adopted by the board of directors.

 

		e)	Reliance on Certain Exemptions

 

At no time since the commencement
of the Company’s most recently completed financial period has the Company relied on the following exemptions under NI 52-110:
section 2.4 (De Minimis Non-Audit Services), section 3.2 (Initial Plublic Offerings), section 3.4 (Events
Outside Control of Member), section 3.5 (Death, Incapacity or Resignation of Audit Committee Member), or an exemption
from NI-52-110 in whole or in part, granted under Part 8 (Exemptions) thereof.

 

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		f)	Pre-Approval Policies and Procedures

 

The Audit Committee has adopted
specific policies and procedures for the engagement of non-audit services, as described in the Audit Committee Charter attached
hereto as Appendix 1 to this Schedule A.

 

		g)	External Auditor Service Fees

 

	Year 

Ending	Audit

 Fees	audit

 related

 fees	tax fees	all 

other

 fees	Total

 fees
	March 31, 2020	$49,627	$14,122	$5,750	Nil	$69,499
	March 31, 2019	$48,805	$5,000	$20,950	Nil	$74,755
	March 31, 2018	$49,725	NIL	NIL	Nil	$49,725

 

“Audit Fees” refers
to the aggregate fees billed by the Company’s external auditors for audit services including interim reviews. “Audit
Related Fees” refers to aggregate fees billed for assurance and related services by the Company’s external auditors
that are reasonably related to the performance of the audit or review of the Company’s financial statements and not reported
under Audit Fees, including the provision of comfort letters and consents, the consultation concerning financial accounting and
reporting of specific issues and the review of documents filed with regulatory authorities. “Tax Fees” includes fees
for professional services rendered by the Company’s external auditors for tax compliance, tax advice and tax planning. “All
Other Fees” includes all fees billed by the Company’s external auditors for services not covered in the other three
categories.

 

    63

     

    

 

Appendix
1

AUDIT COMMITTEE CHARTER

 

 

 

		1.	PURPOSE

 

The primary function of the audit committee
(the “Committee”) is to assist the Board of Directors (the “Board”) of Medicenna Therapeutics Corp. (the
 “Company”) in fulfilling its oversight of, and recommend appropriate actions with respect to (i) the integrity
of the Company’s financial statements, accounting and financial reporting processes, system of internal controls over financial
reporting and audit process, (ii) the Company’s compliance with, and process for monitoring compliance with, legal and
regulatory requirements so far as they relate to matters of financial reporting, (iii) the independent auditor’s qualifications,
independence and performance and (iv) the design, implementation and performance of the Company’s internal audit function.

 

The members of the Committee are not full-time
employees of the Company and may or may not be accountants or auditors by profession or experts in the fields of accounting or
auditing and, in any event, do not serve in such capacity. Consequently, it is not the duty of the Committee to conduct audits
or to determine that the Company’s financial statements and disclosures are complete and accurate and are in accordance with
generally accepted accounting principles and applicable laws, rules and regulations. These are the responsibilities of management
and the external auditors.

 

		2.	Composition

 

(a)            At
Least Three Members. The Committee shall be comprised of a minimum of three directors as determined by the Board upon the recommendation
of the Corporate Governance and Nomination Committee. All of the members of the Committee shall be “independent” as
determined by the Board in compliance with applicable securities laws and applicable rules and guidelines of any stock exchange
on which the securities of the Company are listed and any other laws applicable to the Company, including National Instrument 52-110
 – Audit Committees.

 

All members of the Committee shall also
be “financially literate”, meaning the ability to read and understand a set of financial statements that present a
breadth and level of complexity of accounting issues that are generally comparable to the breadth and complexity of the issues
that can reasonably be expected to be raised by the Company’s financial statements. At least one member of the Committee
shall be a “financial expert”, as such term is defined by the U.S. Securities and Exchange Commission, and have, as
determined by the Board, financial sophistication (including past employment experience in finance or accounting, requisite professional
certification in accounting, or any other comparable experience or background which results in the individual’s financial
sophistication, including being or having a been a chief executive officer, chief financial officer or other senior officer with
financial oversight responsibilities).

 

    64

     

    

 

The Board shall designate a Committee member
as the Chairperson of the Committee, or if the Board does not do so, the Committee members shall appoint a Committee member as
Chairperson by a majority vote of the full Committee membership.

 

(b)            Appointment
and Removal. The Board shall appoint Committee members and designate the Committee’s “financial expert(s)”
at the first meeting of the Board following each Annual General Meeting upon the recommendation of the Corporate Governance and
Nomination Committee. Such members shall meet the independence, experience and expertise requirements under applicable securities
law and the applicable rules and guidelines of any stock exchange on which the securities of the Company are listed and applicable
policies of the Board. Members of the Committee shall serve for one year terms and until their successors are appointed. The Board
may fill vacancies on the Committee by a majority vote of the authorized numbers of directors, but may remove Committee members
only with the approval of a majority of the other independent directors then serving on the full Board.

 

		3.	Meetings, Reports and Resources of the Audit Committee

 

(a)            Meetings.
In discharging its responsibilities, the Committee shall meet as often as it determines necessary or advisable, but not less frequently
than quarterly. The Committee may also hold special meetings or act by unanimous written consent as the Committee may decide. The
meetings may be in person or telephone. The Committee shall keep written minutes of its meetings and shall deliver a copy of such
minutes to the Board and to the corporate secretary of the Company for inclusion in the Company’s minute books, and reports
of Committee meetings will be presented at the next regularly scheduled Board meeting. The Committee may meet in separate executive
sessions with other directors, the CEO and other Company employees, agents or representatives invited by the Committee. At least
annually, the Committee will also meet separately with the independent auditors and/or the held of internal audit (or, if applicable,
internal audit service providers), without management present.

 

(b)            Procedures.
The Committee may establish its own procedures, including the formation and delegation of authority to subcommittees, in a manner
not inconsistent with this charter, the articles, applicable securities laws, or the applicable rules and guidelines of any
stock exchange on which the securities of the Company are listed. The Chairperson or majority of the Committee members may call
meetings of the Committee. A majority of the authorized number of Committee members shall constitute a quorum for the transaction
of Committee business, and the vote of a majority of the Committee members present at the meeting at which a quorum is present
shall be the act of the Committee. The Committee shall review and reassess at least annually the adequacy of this charter and recommend
to the Board for approval any proposed changes, including any changes necessary to comply with applicable securities laws and applicable
rules and guidelines of any stock exchange on which the securities of the Company are listed and any other laws applicable.

 

(c)            Resources.
The Committee shall have the authority, in its sole discretion, to (i) engage independent counsel and other advisors as it
determines necessary to carry out its duties, (ii) set and pay the compensation for any advisors employed by the Committee,
and (iii) communicate directly with the internal and external auditors. The Company shall provide funding, as determined appropriate
by the Committee and in the Committee’s sole authority, for payment of compensation to any registered public accounting firm
engagement for the purpose of preparing or issuing an audit report or performing other audit, review or attest services for the
Company; compensation to any advisers employed by the Committee, as it determines necessary to carry out its duties; and ordinary
administrative expenses of the Committee that are necessary or appropriate in carrying out the Committee’s duties.

 

    65

     

    

 

		4.	Authority and Responsibilities

 

In furtherance of its purpose, the Committee
shall have the following authority and responsibilities:

 

		(a)	be directly responsible for appointing and recommending to the Board and the shareholders: (i) the
external auditor for the purpose of preparing or issuing an auditor’s report or performing other audit, review or attest
services for the Company; and (ii) the compensation of the external auditor;

 

		(b)	be directly responsible for retaining and overseeing the work of the external auditor engaged for
the purpose of preparing or issuing an auditor’s report or performing other audit, review or attest services for the Company,
including the resolution of disagreements between management and the external auditor regarding financial reporting, with the external
auditor reporting directly to the Committee;

 

		(c)	pre-approve all non-audit services to be provided to the Company or its subsidiary entities by
the Company’s external auditor in accordance with the pre-approval process noted below;

 

		(d)	review the accounting principles and practices to be applied and followed by the Company during
the fiscal year and any significant changes from those applied and followed during the previous year;

 

		(e)	review the adequacy of the systems of internal accounting and audit policies, practices and controls
established by the Company, and discuss with the auditor the results of its reviews and reports;

 

		(f)	review all litigation and claims involving or against the Company which could materially adversely
affect its financial position and which the auditor or any officer of the Company may refer to the Committee;

 

		(g)	ensure that the auditor submits on a periodic basis to the Committee, and review and discusses
at least annually with the auditor, a formal written statement delineating all relationships between the auditor and the Company,
consistent with applicable auditor independence standards, and to review such statement and to actively engage in a dialogue with
the auditor with respect to any disclosed or undisclosed relationships or services that may impact on the objectivity and independence
of the auditor, and to review the statement and the dialogue with the Board and recommend to the Board appropriate action to ensure
the independence of the auditor;

 

		(h)	obtain written confirmation from the independent auditor that it is objective within the meaning
of the Rules of Professional Conduct/Code of Ethics adopted by the provincial institute or order of Chartered Accountants
to which it belongs and is an independent public accountant within the meaning of the Independence Standards of the Canadian Institute
of Chartered Accountants and as required by applicable law or standards of the Public Company Accounting Oversight Board (the “PCAOB”),
or any successor body;

 

		(i)	meet with the auditor at least once per quarter without management present to allow a candid discussion
regarding any concerns the auditor may have and to resolve any disagreements between the auditor and management regarding the Company’s
financial reporting;

 

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		(j)	review the annual consolidated financial statements of the Company and the notes thereto following
the examination thereof by the auditor and prior to their approval by the Board and report to the Board thereon;

 

		(k)	review and approve the quarterly financial statements, notes thereto and quarterly management discussion
and analysis (MD&A) and related press releases of the Company prior to their release;

 

		(l)	review the annual MD&A, and other public disclosure documents and related press releases, including
any prospectus prior to their approval by the directors.

 

		(m)	be satisfied that adequate procedures are in place for the review of the Company’s public
disclosure of financial information extracted or derived from the Company’s financial statements and must periodically assess
the adequacy of those procedures;

 

		(n)	establish procedures for (i) the receipt, retention and treatment of complaints received by
the Company regarding accounting, internal accounting controls, or auditing matters; and (ii) the confidential, anonymous
submission by employees of the Company of concerns regarding questionable accounting or auditing matters;

 

		(o)	approve the Whistleblower Policy and review and assess the adequacy of the policy on an annual
basis, or more often if deemed appropriate;

 

		(p)	discuss with management and the external auditor any other matters required to be communicated
to the Committee by the external auditor under applicable standards of the PCAOB or applicable law or listing standards;

 

		(q)	review and approve the Company’s hiring policies regarding partners, employees and former
partners and employees of the present and former external auditor of the Company;

 

		(r)	review, approve and oversee any related-party transactions (as defined in applicable securities
laws and stock exchange rules and guidelines);

 

		(s)	review the adequacy of insurance policies maintained by the Company;

 

		(t)	approve the Corporate Disclosure and Trading Policy and review and assess the adequacy of the policy
on an annual basis, or more often if deemed appropriate; and

 

		(u)	consider any other matter which in its judgment should be taken into account in reaching its recommendation
to the Board concerning the approval of the financial statements.

 

		5.	Pre-Approval of Non-Audit Services

 

The Committee satisfies the pre-approval
requirement of item 4(c) of its Responsibilities if:

 

		(a)	the aggregate amount of all the non-audit services that were not pre-approved is reasonably expected
to constitute no more than five per cent of the total amount of fees paid by the Company and its subsidiary entities to the Company’s
external auditor during the fiscal year in which the services are provided;

 

    67

     

    

 

		(b)	the Company or the subsidiary entity of the Company, as the case may be, did not recognize the
services as non-audit services at the time of the engagement; and

 

		(c)	the services are promptly brought to the attention of the Committee of the Company and approved,
prior to the completion of the audit, by the Committee or by one or more of its members to whom authority to grant such approvals
has been delegated by the Committee.

 

The Committee may delegate to one or more
members the authority to pre-approve non-audit services in satisfaction of the requirement of item 4.(c) of its Responsibilities.
The pre-approval of non-audit services by any member to whom authority has been delegated pursuant hereto must be presented to
the Committee at its first scheduled meeting following such pre-approval.

 

The Committee satisfies the pre-approval
requirement of item 4.(c) of its Responsibilities if it adopts specific policies and procedures for the engagement of the
non-audit services, if: (i) the pre-approval policies and procedures are detailed as to the particular service; (ii) the
Committee is informed of each non-audit service; and (iii) the procedures do not include delegation of the Committee’s
responsibilities to management.

 

    68Exhibit 4.2

 

 

Consolidated financial statements of

 

Medicenna Therapeutics Corp.

 

(Expressed in Canadian Dollars)

 

For the years ended March 31, 2020 and 2019

 

    

     

    

 

REPORT OF INDEPENDENT REGISTERED PUBLIC
ACCOUNTING FIRM

 

To the Shareholders and Directors of 

Medicenna Therapeutics Corp

 

Opinion on the Consolidated Financial Statements

 

We have audited the accompanying consolidated
financial statements of Medicenna Therapeutics Corp (the “Company”), which comprise the consolidated statements of
financial position as of March 31, 2020 and 2019, the consolidated statements of operations, cash flows and changes in shareholders’
equity for the years ended March 31, 2020 and 2019 and the related notes, comprising a summary of significant accounting policies
and other explanatory information (collectively referred to as the consolidated financial statements).

 

In our opinion, these consolidated financial
statements present fairly, in all material respects, the financial position of the Company as at March 31, 2020 and 2019 and
its financial performance and its cash flows for the years ended March 31, 2020 and 2019 in accordance with International
Financial Reporting Standards as issued by the International Accounting Standards Board.

 

Basis for Opinion

 

A - Management’s Responsibility
for the consolidated Financial Statements

 

Management is responsible for the preparation
and fair presentation of these consolidated financial statements in accordance with International Financial Reporting Standards
as issued by the International Accounting Standards Board, and for such internal control as management determines is necessary
to enable the preparation of consolidated financial statements that are free from material misstatement, whether due to fraud or
error.

 

B - Auditors’ Responsibility

 

Our responsibility is to express an opinion
on these consolidated financial statements based on our audits. We conducted our audits in accordance with Canadian generally accepted
auditing standards and the standards of the Public Company Accounting Oversight Board (United States) (“PCAOB”). Those
standards require that we plan and perform the audit to obtain reasonable assurance about whether the consolidated financial statements
are free from material misstatement, whether due to error or fraud. Those standards also require that we comply with ethical requirements,
including independence. We are required to be independent with respect to the Company in accordance with the ethical requirements
that are relevant to our audit of the consolidated financial statements in Canada, the U.S. federal securities laws and the applicable
rules and regulations of the Securities and Exchange Commission and the PCAOB. We are a public accounting firm registered
with the PCAOB.

 

An audit includes performing procedures
to assess the risks of material misstatements of the consolidated financial statements, whether due to error or fraud, and performing
procedures to respond to those risks. Such procedures included obtaining and examining, on a test basis, audit evidence regarding
the amounts and disclosures in the consolidated financial statements. The procedures selected depend on our judgment, including
the assessment of the risks of material misstatement of the consolidated financial statements, whether due to fraud or error. In
making those risk assessments, we consider internal control relevant to the Company’s preparation and fair presentation of
the consolidated financial statements in order to design audit procedures that are appropriate in the circumstances, but not for
the purpose of expressing an opinion on the effectiveness of the Company’s internal control. The Company is not required
to have, nor were we engaged to perform, an audit of its internal control over financial reporting. Accordingly, we express no
such opinion.

 

    1

     

    

 

An audit also includes evaluating the appropriateness
of accounting policies and principles used and the reasonableness of accounting estimates made by management, as well as evaluating
the overall presentation of the consolidated financial statements.

 

We believe that the audit evidence we have
obtained in our audits is sufficient and appropriate to provide a reasonable basis for our audit opinion.

 

We have served as the Company’s auditor
since 2015.

 

	Vancouver, Canada	Chartered Professional Accountants

 

May 13, 2020

 

    2

     

    

 

Medicenna Therapeutics
Corp.

Consolidated
Statements of Financial Position

(Expressed
in Canadian Dollars)

 

as at

	 	 	March
    31, 2020	 	 	March
    31, 2019	 
	 	 	$	 	 	$	 
	Assets	 	 	 	 	 	 	 	 
	Current assets	 	 	 	 	 	 	 	 
	Cash and cash equivalents	 	 	22,697,654	 	 	 	2,370,976	 
	Marketable securities	 	 	15,002,548	 	 	 	-	 
	Prepaids and deposits	 	 	93,752	 	 	 	258,423	 
	Government grant receivable
    (Note 11)	 	 	-	 	 	 	2,444,285	 
	Other receivables	 	 	58,295	 	 	 	32,539	 
	 	 	 	37,852,249	 	 	 	5,106,223	 
	Intangible assets (Note 12)	 	 	76,259	 	 	 	81,205	 
	Right-of-use assets (Note 4)	 	 	67,760	 	 	 	-	 
	 	 	 	37,996,268	 	 	 	5,187,428	 
	Liabilities	 	 	 	 	 	 	 	 
	Current liabilities	 	 	 	 	 	 	 	 
	Accounts payable and accrued
    liabilities (Note 7)	 	 	1,779,883	 	 	 	2,396,439	 
	Current
    portion of lease liability (Note 4)	 	 	35,344	 	 	 	-	 
	 	 	 	1,815,227	 	 	 	2,396,439	 
	License fee payable (Note 12)	 	 	-	 	 	 	174,432	 
	Lease liability
    (Note 4)	 	 	31,969	 	 	 	-	 
	 	 	 	1,847,196	 	 	 	2,570,871	 
	Shareholders' Equity	 	 	 	 	 	 	 	 
	Common shares (Note 8)	 	 	56,577,414	 	 	 	16,615,648	 
	Contributed surplus (Notes 9
    and 10)	 	 	10,389,926	 	 	 	8,633,395	 
	Accumulated other comprehensive
    income	 	 	248,452	 	 	 	157,165	 
	Deficit	 	 	(31,066,720	)	 	 	(22,789,651	)
	 	 	 	36,149,072	 	 	 	2,616,557	 
	 	 	 	37,996,268	 	 	 	5,187,428	 

 

	Nature of business (Note
    1)	 	 
	Subsequent events (Note 16)	 	 
	 	 	 
	 	 	 
	Approved by the Board	 	 
	 	 	 
	/s/
    Albert Beraldo	 	Director
	 	 	 
	/s/
    Chandra Panchal	 	Director

 

The accompanying notes are an integral part of these consolidated financial statements.

 

    3

     

    

 

Medicenna Therapeutics
Corp.

Consolidated Statements
of Operations

(Expressed in Canadian Dollars)

 

	 	 	Year ended	 	 	Year ended	 
	 	 	March 31,	 	 	March 31,	 
	 	 	2020	 	 	2019	 
	 	 	$	 	 	$	 
	Operating expenses	 	 	 	 	 	 	 	 
	General and administration (Note 15)	 	 	2,375,211	 	 	 	1,709,286	 
	Research and development (Note 15)	 	 	5,869,588	 	 	 	3,017,997	 
	Total operating expenses	 	 	8,244,799	 	 	 	4,727,283	 
	Finance income	 	 	(6,727	)	 	 	(102	)
	Foreign exchange (gain) loss	 	 	38,997	 	 	 	(19,150	)
	 	 	 	32,270	 	 	 	(19,252	)
	Net loss for the year	 	 	(8,277,069	)	 	 	(4,708,031	)
	Cummulative translation adjustment	 	 	91,287	 	 	 	6,256	 
	Comprehensive loss for the year	 	 	(8,185,782	)	 	 	(4,701,775	)
	Basic and diluted loss per share for the year	 	 	(0.26	)	 	 	(0.18	)
	Weighted average number of common shares outstanding (Note 8(b))	 	 	31,899,640	 	 	 	25,674,027	 

 

The accompanying notes are an integral part of these consolidated
financial statements.

 

    4

     

    

 

Medicenna Therapeutics Corp.

Consolidated Statements of Cash Flows

(Expressed
in Canadian Dollars)

 

	 	 	Year ended	 	 	Year ended	 
	 	 	March 31,	 	 	March 31,	 
	 	 	2020	 	 	2019	 
	 	 	$	 	 	$	 
	Operating activities	 	 	 	 	 	 	 	 
	Net loss for the year	 	 	(8,277,069	)	 	 	(4,708,031	)
	Items not involving cash	 	 	 	 	 	 	 	 
	Depreciation	 	 	7,892	 	 	 	6,818	 
	Stock based compensation	 	 	1,124,977	 	 	 	998,619	 
	R&D warrant expense	 	 	-	 	 	 	710,574	 
	Government grant expense recoveries	 	 	(1,076,538	)	 	 	(5,646,227	)
	Unrealized foreign exchange	 	 	61,526	 	 	 	(82,419	)
	Accrued interest	 	 	(2,548	)	 	 	-	 
	Changes in non-cash working capital	 	 	 	 	 	 	 	 
	Other receivables and deposits	 	 	138,915	 	 	 	56,862	 
	Accounts payable and accrued liabilities	 	 	(931,556	)	 	 	626,799	 
	 	 	 	(8,954,401	)	 	 	(8,037,005	)
	Investing activities	 	 	 	 	 	 	 	 
	Purchase of marketable securities	 	 	(15,000,000	)	 	 	-	 
	Long term license fee payable	 	 	-	 	 	 	(354,458	)
	 	 	 	(15,000,000	)	 	 	(354,458	)
	Financing activities	 	 	 	 	 	 	 	 
	Repayment of lease liabilities	 	 	(3,393	)	 	 	-	 
	Government grant received (Note 11)	 	 	3,539,465	 	 	 	3,242,073	 
	Issuance of share capital, net of issuance costs (Note 8(a))	 	 	38,375,045	 	 	 	3,579,910	 
	Warrant and option exercises (Note 9)	 	 	2,372,820	 	 	 	-	 
	 	 	 	44,283,937	 	 	 	6,821,983	 
	Effect of foreign exchange on cash	 	 	(2,857	)	 	 	31,722	 
	Net increase (decrease) in cash	 	 	20,326,678	 	 	 	(1,567,758	)
	Cash, beginning of year	 	 	2,370,976	 	 	 	3,938,734	 
	Cash, end of year	 	 	22,697,654	 	 	 	2,370,976	 
	 	 	 	 	 	 	 	 	 
	Other non-cash transactions	 	 	 	 	 	 	 	 
	Broker warrants issued	 	$	561,406	 	 	$	91,000	 
	Warrants issued	 	$	705,218	 	 	$	1,042,861	 
	Share issuance costs accrued through	 	 	 	 	 	 	 	 
	accounts payable and accrued liabilities	 	$	257,141	 	 	$	102,596	 

 

The accompanying notes are an integral part of these consolidated
financial statements.

 

    5

     

    

 

Medicenna Therapeutics Corp.

Consolidated Statements of Changes in Shareholders' Equity

(Expressed
in Canadian Dollars)

 

	 	 	Common shares issued and	 	 	Contributed	 	 	Accumulated other	 	 	Deficit	 	 	Total	 
	 	 	outstanding	 	 	Surplus	 	 	comprehensive	 	 	 	 	 	shareholders'	 
	 	 	 	 	 	 	 	 	 	 	 	income	 	 	 	 	 	equity	 
	 	 	Number	 	 	Amount	 	 	 	 	 	 	 	 	 	 	 	 	 
	 	 	 	 	 	$	 	 	$	 	 	$	 	 	$	 	 	$	 
	Balance, March 31, 2018	 	 	24,578,137	 	 	 	14,302,195	 	 	 	5,790,341	 	 	 	150,909	 	 	 	(18,081,620	)	 	 	2,161,825	 
	Stock based compensation	 	 	-	 	 	 	-	 	 	 	998,619	 	 	 	-	 	 	 	-	 	 	 	998,619	 
	Research and development warrant amortization	 	 	-	 	 	 	-	 	 	 	710,574	 	 	 	-	 	 	 	-	 	 	 	710,574	 
	Issued on December 2018 financing (Notes 8, 9)	 	 	4,000,000	 	 	 	2,313,453	 	 	 	1,133,861	 	 	 	-	 	 	 	-	 	 	 	3,447,314	 
	Net loss and comprehensive loss	 	 	-	 	 	 	-	 	 	 	-	 	 	 	6,256	 	 	 	(4,708,031	)	 	 	(4,701,775	)
	Balance, March 31, 2019	 	 	28,578,137	 	 	 	16,615,648	 	 	 	8,633,395	 	 	 	157,165	 	 	 	(22,789,651	)	 	 	2,616,557	 
	Stock based compensation	 	 	-	 	 	 	-	 	 	 	1,124,977	 	 	 	-	 	 	 	-	 	 	 	1,124,977	 
	Warrant and option exercises	 	 	1,623,675	 	 	 	3,007,890	 	 	 	(635,070	)	 	 	-	 	 	 	-	 	 	 	2,372,820	 
	Issued on October 2019 financing  (Notes 8, 9)	 	 	5,307,693	 	 	 	5,319,361	 	 	 	810,608	 	 	 	-	 	 	 	-	 	 	 	6,129,969	 
	Issued on March 2020 financing (Notes 8, 9)	 	 	11,290,323	 	 	 	31,634,515	 	 	 	456,016	 	 	 	-	 	 	 	-	 	 	 	32,090,531	 
	Net loss and comprehensive loss	 	 	-	 	 	 	-	 	 	 	-	 	 	 	91,287	 	 	 	(8,277,069	)	 	 	(8,185,782	)
	Balance, March 31, 2020	 	 	46,799,828	 	 	 	56,577,414	 	 	 	10,389,926	 	 	 	248,452	 	 	 	(31,066,720	)	 	 	36,149,072	 

 

The
accompanying notes are an integral part of these consolidated financial statements.

 

    6

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian
Dollars)

 

	1.	Nature of business

 

Medicenna Therapeutics Corp.
(“Medicenna” or the "Company") was incorporated as A2 Acquisition Corp. (“A2”) under the Alberta
Business Corporations Act on February 2, 2015 and was classified as a Capital Pool Corporation ("CPC") as defined
in Policy 2.4 of the TSX Venture Exchange Inc. (the "Exchange") Corporate Finance Manual. On March 1, 2017, the
Company completed a qualifying transaction with Medicenna Therapeutics Inc. (“MTI.”) and the name of the Company was
changed to Medicenna Therapeutics Corp. (the “Transaction”). MTI has been identified for accounting purposes as the
acquirer, and accordingly the entity is considered to be a continuation of MTI and the net assets of A2 at the date of the Transaction
are deemed to have been acquired by MTI. These consolidated financial statements include the results of operations of Medicenna
from March 1, 2017. On August 2, 2017 Medicenna graduated to the main board of the Toronto Stock Exchange. On November 13,
2017, Medicenna continued under the Canadian Business Corporations Act.

 

Medicenna has three wholly owned
subsidiaries, Medicenna Therapeutics Inc. (“MTI”) (British Columbia), Medicenna Biopharma Inc. (“MBI”)
(Delaware) and Medicenna Biopharma Inc. (“MBIBC”). (British Columbia).

 

The
Company's principal business activity is the development and commercialization of Empowered CytokinesÔ
and SuperkinesÔ
for the treatment of cancer.

 

As at March 31, 2020, the
head and registered office is located at 2 Bloor St W, 7th Floor, Toronto, Ontario, Canada.

 

	2.	Significant accounting policies

 

		a)	Basis of Measurement and statement of compliance

 

These consolidated financial
statements have been prepared in accordance with International Financial Reporting Standards (“IFRS”) as issued by
the International Accounting Standards Board (“IASB”) and the Interpretations of the International Financial Reporting
and Interpretations Committee (“IFRIC”).

 

The consolidated financial statements
have been prepared on a historical cost basis except for certain financial assets measured at fair value. In addition, these consolidated
financial statements have been prepared using the accrual basis of accounting, except for cash flow information.

 

The consolidated financial statements
were approved by the Company’s Board of Directors and authorized for issue on May 14, 2020.

 

		b)	Principles of Consolidation

 

These consolidated financial
statements include the accounts of the Company and its wholly-owned Subsidiaries MTI, MBI and MBIBC (British Columbia, Inactive).
Subsidiaries are fully consolidated from the date at which control is determined to have occurred and are deconsolidated from the
date that the Company no longer controls the entity. The financial statements of the subsidiaries are prepared for the same reporting
period as the Company using consistent accounting policies. Intercompany transactions, balances, and gains and losses on transactions
between subsidiaries are eliminated.

 

		c)	Foreign currency

 

The functional currency of an
entity is the currency of the primary economic environment in which the entity operates. The functional currency of the Company,
MTI and MBIBC is the Canadian dollar. The functional currency of MBI is the US dollar. The functional currency determinations were
conducted through an analysis of the consideration factors identified in IAS 21 – The Effects of Changes in Foreign Exchange
Rates.

 

    7

     

    

 

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian Dollars)

 

		2.	Significant accounting
policies cont’d

 

		d)	Foreign currency

 

Transactions in foreign currencies
are translated to the functional currency at the rate on the date of the transactions. Monetary assets and liabilities denominated
in foreign currencies are retranslated at the spot rate of exchange as at the reporting date. All differences are taken to profit
or loss. Non-monetary items that are measured in terms of historical cost in a foreign currency are translated using the exchange
rate as at the date of the initial transaction. Non-monetary items measured at fair value in a foreign currency are translated
using the exchange rate at the date when the fair value was determined.

 

On translation of the entities
whose functional currency is other than the Canadian dollar, revenues and expense are translated at the exchange rates approximating
those in effect on the date of the transactions. Assets and liabilities are translated at the spot rate of exchange as at the reporting
date. Exchange gains and losses, including results of retranslation, are recorded in other comprehensive income.

 

		e)	Cash and cash equivalents, marketable securities

 

Cash and cash equivalents

 

Cash equivalents include guaranteed
investment certificates (March 31, 2020 - $20,004,153, March 31, 2019 - $nil) with a maturity of 90 days or less. The
Company has classified its cash and cash equivalents at fair value through profit or loss.

 

Marketable securities

 

Marketable securities consist
of guaranteed investment certificates with a maturity of greater than 90 days and less than one year. The Company has classified
its marketable securities at fair value through profit or loss.

 

		f)	Research and development costs

 

Expenditures on research and
development activities, undertaken with the prospect of gaining new scientific or technical knowledge and understanding, are recognized
in profit or loss as incurred. Investment tax credits related to current expenditures are included in the determination of net
income as the expenditures are incurred when there is reasonable assurance they will be realized.

 

Development activities involve
a plan or design for the production of new or substantially improved products and processes. Development expenditures are capitalized
only if development costs can be measured reliably, the product or process is technically and commercially feasible, future economic
benefits are probable, and the Company intends to and has sufficient resources to complete development and to use or sell the asset.
These criteria will be deemed by the Company to have been met when revenue is received by the Company and a determination that
it has sufficient resources to market and sell its product offerings. Upon a determination that the criteria to capitalize development
expenditures have been met, the expenditures capitalized will include the cost of materials, direct labour and overhead costs that
are directly attributable to preparing the asset for its intended use. Other development expenditures will be expensed as incurred.

 

Capitalized development
expenditures will be measured at cost less accumulated amortization and accumulated impairment losses. No development costs
have been capitalized to date.

 

		g)	Government assistance

 

Government grants, including
grants from similar bodies, consisting of investment tax credits are recorded as a reduction of the related expense or cost of
the asset acquired. Government grants are recognized when there is reasonable assurance that the Company has met the requirements
of the approved grant program and there is reasonable assurance that the grant will be received.

 

Research grants that compensate
the Company for expenses incurred are recognized in profit, or loss in reduction thereof on a systematic basis in the same years
in which the expenses are recognized.

 

    6

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian Dollars)

 

		2.	Significant accounting
policies cont’d

 

Grants that compensate the Company
for the cost of an asset are recognized in profit or loss on a systematic basis over the useful life of the asset.

 

		h)	Intangible assets

 

The Company owns certain patents,
intellectual property licenses and options to acquire intellectual property. The Company expenses patent costs, including license
fees and other maintenance costs, until such time as the Company has certainty over the future recoverability of the intellectual
property at which time it capitalizes the costs incurred. The Company capitalizes costs directly related to the acquisition of
existing license patents.

 

The Company does not hold any
intangible asset with an indefinite life.

 

Intangible assets with
finite lives are amortized over the useful economic life and assessed for impairment whenever there is an indication that the
intangible asset may be impaired. The amortization method and amortization period of an intangible asset with a finite life
is reviewed at least annually. Changes in the expected useful life or the expected pattern of consumption of future economic
benefits embodied in the asset is accounted for by changing the amortization period or method, as appropriate, and are
treated as changes in accounting estimates. The amortization expense on intangible assets with finite lives is recognized in
general and administrative expenses.

 

Amortization is recognized in
profit or loss on a straight-line basis over the estimated useful lives of intangible assets from the date they are available for
use to August 31, 2035.

 

		i)	Income taxes

 

Current tax and deferred tax
are recognized in the Company’s profit and loss, except to the extent that it relates to a business combination or items
recognized directly in equity or in net loss and comprehensive loss.

 

Current income taxes are recognized
for the estimated taxes payable or receivable on taxable income or loss for the current year and any adjustment to income taxes
payable in respect of previous years. Current income taxes are determined using tax rates and tax laws that have been enacted or
substantively enacted by the period end date.

 

Deferred tax assets and liabilities
are recognized where the carrying amount of an asset or liability differs from its tax base, except for taxable temporary differences
arising on the initial recognition of goodwill and temporary differences arising on the initial recognition of an asset or liability
in a transaction which is not a business combination and at the time of the transaction affects neither accounting nor taxable
profit or loss.

 

Recognition of deferred tax assets
for unused tax losses, tax credits and deductible temporary differences is restricted to those instances where it is probable that
future taxable profit will be available against which the deferred tax assets can be utilized. At the end of each reporting period,
the Company reassesses unrecognized deferred tax assets. The Company recognizes a previously unrecognized deferred tax asset to
the extent that it has been probable that future taxable profit will allow the deferred tax asset to be recovered.

 

		j)	Basic and diluted loss per common share

 

Basic loss per share is
computed by dividing the loss available to common shareholders by the weighted average number of common shares outstanding
during the year. The computation of diluted earnings per share assumes the conversion, exercise or contingent issuance of
securities only when such conversion, exercise or issuance would have a dilutive effect on earnings per share. The dilutive
effect of convertible securities is reflected in diluted earnings per share by application of the “if converted”
method. The dilutive effect of outstanding options and warrants and their equivalents is reflected in diluted earnings per
share. Since the Company has losses, the exercise of outstanding options and warrants has not been included in this
calculation as it would be anti-dilutive.

 

    7

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian Dollars)

 

		2.	Significant accounting
policies cont’d

 

		k)	Equipment

 

The Company’s
fixed assets comprise of computer equipment for use in general and administrative and research activities.

 

Depreciation is recognized using
the straight-line method based on an expected life of the assets

 

	 	 
	Computer equipment	2 years
	Right-of-use-assets	Over the lease term
	 	 

 

Impairment of long-lived assets:

 

The Company’s long-lived
assets are reviewed for indications of impairment at the date of preparing each statement of financial position. If indication
of impairment exists, the asset’s recoverable amount is estimated.

 

An impairment loss is recognized
when the carrying value of an asset, or its cash-generating unit, exceeds its recoverable amount. A cash-generating unit is the
smallest identifiable group of assets that generates cash inflows that are largely independent of cash inflows from other assets
or groups of assets. For the purpose of impairment testing, the Company determined it has one cash-generating unit. The recoverable
amount is the greater of the asset’s fair value less cost to sell and value in use.

 

		l)	Stock-based compensation

 

The Company has a stock-based
compensation plan (the "Plan") available to officers, directors, employees and consultants with grants under the Plan
approved by the Company's Board of Directors. Under the Plan, the exercise price of each option equals the closing trading price
of the Company's stock on the day prior to the grant or a higher price as determined by the Board of Directors. Vesting is provided
for at the discretion of the Board of Directors and the expiration of options is to be not greater than 10 years from the date
of grant. The Company uses the fair value-based method of accounting for employee awards granted under the Plan. The Company calculates
the fair value of each stock option grant using the Black Scholes option pricing model at the grant date. The stock-based compensation
cost of the options is recognized as stock-based compensation expense over the relevant vesting period of the stock options using
an estimate of the number of options that will eventually vest.

 

Stock options awarded to non-employees
are accounted for at the fair value of the goods received or the services rendered. The fair value is measured at the date the
Company obtains the goods or the date the counterparty renders the service. If the fair value of the goods or services cannot be
reliably measured, the fair value of the options granted will be used.

 

		m)	Share Capital

 

Common shares are classified
as equity. Incremental costs directly attributable to the issue of common shares are recognized as a reduction of equity.

 

The Corporation has
adopted a relative fair value method with respect to the measurement of shares and warrants issued as private placement
units. The relative fair value method allocates value to each component on a pro-rata basis, based on the fair value of the
components calculated independently of one another. The Company measures
the fair value of the warrant component of the unit using the Black-Scholes option pricing model. The unit value is then allocated,
pro-rata, between the two components, with the fair value attributed to the warrants being recorded to contributed surplus.

 

    8

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian Dollars)

 

		2.	Significant accounting
policies cont’d

 

		n)	Financial Instruments

 

Financial assets and liabilities
are recognized when the Company becomes a party to the contractual provisions of the instrument. Financial assets are derecognized
when the rights to receive cash flows from the assets have expired or have been transferred and the Company has transferred substantially
all risks and rewards of ownership.

 

Financial assets and liabilities
are offset and the net amount is reported in the consolidated statement of financial position when there is a legally enforceable
right to offset the recognized amounts and there is an intention to settle on a net basis, or realize the asset and settle the
liability simultaneously.

 

The Company recognizes financial
instruments based on their classification. Depending on the financial instruments’ classification, changes in subsequent
measurements are recognized in net loss and comprehensive loss.

 

The Company has implemented the
following classifications:

 

		·	Cash, cash equivalents and marketable
securities are classified at fair value through profit or loss.

 

		·	Government grant receivable and amounts
receivable are classified as amortized cost. After their initial fair value measurement, they are measured at amortized cost using
the effective interest method; and

 

		·	Accounts payable and accrued liabilities
are classified as other amortized cost. After their initial fair value measurement, they are measured at amortized cost using the
effective interest method.

 

Impairment of financial assets

 

The Company applies the simplified
method of the expected credit loss model required under IFRS 9. Under this method, the Company estimates a lifetime expected loss
allowance for all receivables. Receivables are written off when there is no reasonable expectation of recovery.

 

If there is objective evidence
that an impairment loss has been incurred, the amount of the loss is measured as the difference between the asset’s carrying
amount and the present value of estimated future cash flows. The present value of the estimated future cash flows is discounted
at the financial asset’s original effective interest rate.

 

		o)	Employee benefits

 

Short-term employee benefit obligations
are measured on an undiscounted basis and are expensed as the related service is provided. A liability is recognized for the amount
expected to be paid in short-term cash bonuses if the Company expects to pay these amounts as approved by the Board of Directors
as a result of past services provided by the employee and the obligation can be estimated reliably.

 

		p)	Provisions

 

A provision is recognized if,
as a result of a past event, the Company has a present legal or constructive obligation that can be estimated reliably, and it
is probable that an outflow of economic benefits will be required to settle the obligation. Provisions are assessed by discounting
the expected future cash flows at a pre-tax rate that reflects current market assessments of the time value of money

 

    9

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian Dollars)

 

 

		2.	Significant accounting
policies cont’d

 

and the risks specific to the
liability. The unwinding of the discount on provisions is recognized in finance costs. A provision for onerous contracts is recognized
when the unavoidable costs of meeting the obligations under the contract exceed the economic benefits expected to be received under
it. The provision is measured at the present value of the lower of the expected cost of terminating the contract and the expected
net cost of continuing with the contract.

 

		3.	Key sources of estimation uncertainty

 

The preparation
of consolidated financial statements requires management to make estimates and assumptions that affect the reported amounts of
assets and liabilities and disclosure of contingent assets and liabilities at the date of the consolidated financial statements
and the reported amounts of revenue and expenses during the reporting period. Actual results could differ from those estimates.
Estimates and underlying assumptions are reviewed on an ongoing basis. Revisions to accounting estimates are accounted for prospectively.

 

The key
sources of estimation uncertainty that have a significant risk of causing material adjustment to the carrying amounts of assets
and liabilities are discussed below:

 

Deferred taxes

 

The determination
of deferred income tax assets or liabilities requires subjective assumptions regarding future income tax rates and the likelihood
of utilizing tax carry-forwards. Changes in these assumptions could materially affect the recorded amounts, and therefore do not
necessarily provide certainty as to their recorded values.

 

Valuation of stock-based
compensation and warrants

 

Management
measures the costs for stock-based compensation and warrants using market-based option valuation techniques. Assumptions are made
and estimates are used in applying the valuation techniques. These include estimating the future volatility of the share price,
expected dividend yield, expected risk-free interest rate, future employee turnover rates, future exercise behaviours and corporate
performance. Such estimates and assumptions are inherently uncertain. Changes in these assumptions affect the fair value estimates
of stock-based compensation and warrants.

 

Intangible assets

 

The Company
estimates the useful lives of intangible assets from the date they are available for use in the manner intended by management and
periodically reviews the useful lives to reflect management’s intent about developing and commercializing the assets.

 

Functional currency

 

Management
considers the determination of the functional currency of the Company a significant judgment. Management has used its judgment
to determine the functional currency that most faithfully represents the economic effects of the underlying transactions, events
and conditions and considered various factors including the currency of historical and future expenditures and the currency in
which funds from financing activities are generated. A Company’s functional currency is only changed when there is a material
change in the underlying transactions, events and conditions.

 

		4.	Accounting standards

 

The following IFRS pronouncement
has been adopted during fiscal 2020:

 

The Company has adopted new accounting
standard IFRS 16 - Leases, effective for the Company’s annual period beginning April 1, 2019.

 

IFRS 16 sets out the principles
for the recognition, measurement, presentation and disclosure of leases and requires lessees to account for all leases under a
single on-balance sheet model, with certain exemptions. The standard includes two recognition exemptions for lessees – leases
of “low-value” assets and short-term leases with a lease term of 12 months or less. At the commencement date of a lease,
a lessee will recognize a liability to make lease payments and an asset representing the right to use the underlying asset during the lease
term. Lessees will be required to separately recognize the interest expense on the lease liability and the depreciation expense
on the right-of-use asset. Lessees are also required to remeasure the lease liability upon the occurrence of certain events such
as a change in lease term. The lessee will generally recognize the amount of the remeasurement of the lease liability as an adjustment
to the right-of-use asset.

 

    10

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian Dollars)

 

		4.	Accounting standards cont’d

 

At the time of adoption, the
Company did not have any leases which fell under IFRS 16 as all leases had a term of twelve months or less.

 

In March 2020, the Company
entered into an office lease with a term of two years for which it has applied IFRS16.

 

The Company recognized a right-of-use
asset based on the amount equal to the lease liability, adjusted for any related prepaid and accrued lease payments previously
recognized. The lease liability was recognized based on the present value of remaining lease payments, discounted using the incremental
borrowing rate at the date of initial application. The lease payments include fixed payments less any lease incentives receivable,
variable lease payments that depend on an index or rate, and amounts expected to be paid under residual value guarantees. The variable
lease payments that do not depend on an index or a rate are recognized as expense in the period as incurred.

 

The carrying amounts of the Company’s
right-of-use assets and lease liabilities and movements during 2020 were as follows:

 

	 	 	Right of Use Asset	 	 	Lease Liability	 
	 	 	$	 	 	$	 
	Balance March 31, 2019	 	 	-	 	 	 	-	 
	Additions	 	 	70,706	 	 	 	70,706	 
	Depreciation	 	 	(2,946	)	 	 	-	 
	Lease payments	 	 	-	 	 	 	(3,455	)
	Lease interest	 	 	-	 	 	 	62	 
	Balance, March 31, 2020	 	 	67,760	 	 	 	67,313	 
	 	 	 	 	 	 	 	 	 
	Classification:	 	 	 	 	 	 	 	 
	Current portion of lease liabilities	 	 	-	 	 	 	35,344	 
	Long-term portion of lease liabilities	 	 	-	 	 	 	31,969	 
	 	 	 	-	 	 	 	67,313	 

 

		5.	Capital disclosures

 

The Company’s objectives,
when managing capital, are to safeguard cash and cash equivalents as well as maintain financial liquidity and flexibility in order
to preserve its ability to meet financial obligations and deploy capital to grow its businesses.

 

The Company’s financial
strategy is designed to maintain a flexible capital structure consistent with the objectives stated above and to respond to business
growth opportunities and changes in economic conditions. In order to maintain or adjust its capital structure, the Company may
issue shares or issue debt (secured, unsecured, convertible and/or other types of available debt instruments).

 

There were
no changes to the Company’s capital management policy during the year. The Company is not subject to any externally imposed
capital requirements.

 

    11

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian Dollars)

 

		6.	Financial risk management

 

		(a)	Fair value

 

The Company’s financial
instruments recognized on the consolidated statements of financial position consist of cash and cash equivalents, marketable securities,
government grant receivable, other receivables, and accounts payable and accrued liabilities. The fair value of these instruments,
approximate their carrying values due to their short-term maturity.

 

Classification of financial
instruments

 

Financial instruments measured
at fair value on the statement of financial position are summarized into the following fair value hierarchy levels:

 

Level 1:
quoted prices (unadjusted) in active markets for identical assets or liabilities.

 

Level 2: inputs other than quoted
prices included within Level 1 that are observable for the asset or liability

 

Level 3: inputs for the asset or
liability that are not based on observable market data (unobservable inputs).

 

The Company classifies its financial
assets and liabilities depending on the purpose for which the financial instruments were acquired, their characteristics, and management
intent as outlined below:

 

Cash and cash equivalents and
marketable securities are measured using Level 1 inputs and changes in fair value are recognized through profit or loss, with changes
in fair value being recorded in net earnings at each period end.

 

Other receivables and government
grant receivable are measured at amortized cost less impairments.

 

Accounts payable and accrued
liabilities, deferred government grants and license fee payable are measured at amortized cost.

 

The Company has exposure to
the following risks from its use of financial instruments: credit, interest rate, currency and liquidity risk. The Company reviews
its risk management framework on a quarterly basis and makes adjustments as necessary.

 

		(b)	Credit risk

 

Credit risk arises from the potential
that a counterparty will fail to perform its obligations. The financial instruments that are exposed to concentrations of
credit risk consist of cash and cash equivalents and marketable securities.

 

The Company manages credit risk
associated with its cash and cash equivalents and marketable securities by maintaining minimum standards of R1-med or A-high investments
and the Company invests only in highly rated Canadian corporations which are capable of prompt liquidation.

 

		(c)	Interest rate risk

 

Interest rate risk is the risk
that the fair values and future cash flows of the Company will fluctuate because of changes in market interest rates. The Company
believes that its exposure to interest rate risk is not significant.

 

		(d)	Liquidity risk

 

Liquidity risk is the risk that
the Company will not be able to meet its financial obligations as they fall due. The Company currently settles all of its financial
obligations out of cash and cash equivalents. The ability to do so relies on the Company maintaining sufficient cash in excess
of anticipated needs. As at March 31, 2020, the Company’s liabilities consist of accounts payable and accrued liabilities
that have contracted maturities of less than one year.

 

    12

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian Dollars)

 

		6.	Financial risk management cont’d

 

		(e)	Currency risk

 

Currency risk is the risk that
future cash flows of a financial instrument will fluctuate because of changes in foreign exchange rates. The Company is exposed
to currency risk from employee costs as well as the purchase of goods and services primarily in the United States and cash and
cash equivalent balances held in foreign currencies. Fluctuations in the US dollar exchange rate could have a significant impact
on the Company’s results. Assuming all other variables remain constant, a 10% depreciation or appreciation of the Canadian
dollar against the US dollar would result in an increase or decrease in loss and comprehensive loss for the year ended March 31,
2020 of $108,423 (March 31, 2019 - $69,305).

 

Balances in US dollars are as
follows:

 

	 	 	March 31, 2020	 	 	March 31, 2019	 
	 	 	$	 	 	$	 
	Cash and cash equivalents	 	 	134,835	 	 	 	118,440	 
	Accounts payable and accrued liabilities	 	 	(899,992	)	 	 	(1,430,518	)
	Deferred government grant receivable (note 11)	 	 	-	 	 	 	1,831,337	 
	 	 	 	(765,157	)	 	 	519,259	 

 

		7.	Accounts payable and
accrued liabilities

 

	 	 	March 31, 2020	 	 	March 31, 2019	 
	 	 	$	 	 	$	 
	 Trade payables	 	 	456,241	 	 	 	802,025	 
	 Accrued liabilities	 	 	1,323,642	 	 	 	1,594,414	 
	 	 	 	1,779,883	 	 	 	2,396,439	 

 

		8.	Share capital

 

		Authorized

                                   

                                   
	

 

Unlimited common shares

 

		a)	Equity Issuances

 

Year ended March 31, 2020

 

On March 17, 2020, the Company
completed a public offering raising total gross proceeds of $35,000,001. The Company issued 11,290,323 common shares at $3.10 per
share. The Company paid commission to the agents totaling $2,450,000, share issuance costs of $459,470 and issued 790,323 warrants
to the agents exercisable into one common share of the Company at an exercise price of $3.10 for a period of twenty-four months.
The fair value of the warrants issued was determined to be $456,016.

 

On October 17, 2019, the
Company completed a public offering raising total gross proceeds of $6,900,000. The Company issued 5,307,693 units at $1.30, consisting
of 1 common share and 1⁄2 common share purchase warrant. Each whole warrant is exercisable at $1.75 until October 17,
2022. The Company paid commission to the agents totaling $455,175, share issuance costs of $314,856 and issued 350,134 warrants
to the agents exercisable into one common share of the Company at an exercise price of $1.30 for a period of twenty-four months.
The fair value of the warrants issued was determined to be $105,390. The Company has allocated the net proceeds of the offering
to the common shares and the common
share purchase warrants based on their estimated relative fair values. Based on relative fair values, $5,319,361 of the net proceeds
were allocated to the common shares and $705,218 to the common share purchase warrants.

 

    13

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian Dollars)

 

 

		8.	Share capital cont’d

 

Year ended March 31, 2019

 

On December 21, 2018, the
Company closed a short-form prospectus offering of 4,000,000 units for gross proceeds of $4,000,000. Each unit consisted of one
common share of the Company and one-half common share purchase warrant of the Company. Each full warrant entitles the holder to
purchase one common share, for five years after the closing of the offering, at an exercise price of $1.20 per common share. The
Company issued 4,000,000 common shares, 2,000,000 warrants and 280,000 broker warrants in connection with this transaction.

 

The total costs associated with
the transaction were approximately $643,686, including the $91,000 which represented the fair value of the brokers' services provided
as part of the offering and compensated by warrants. Each such broker warrant is exercisable for one common share at a price of
$1.20 per share for a period of 24 months following the closing of the Offering. The Company has allocated the net proceeds of
the offering to the common shares and the common share purchase warrants based on their estimated relative fair values. Based on
relative fair values, $2,313,453 of the net proceeds were allocated to the common shares and $1,042,861 to the common share purchase
warrants.

 

		b)	Calculation of loss per share

 

Loss per common share is calculated using the weighted
average number of common shares outstanding. For the years ended March 31, 2020 and 2019 the calculation was as follows:

 

	 	 	2020	 	 	2019	 
	Common shares issued and outstanding, beginning of year	 	 	28,578,137	 	 	 	24,578,137	 
	Effect of warrants and options exercised	 	 	482,319	 	 	 	-	 
	Shares issued in December 2018 financing	 	 	-	 	 	 	1,095,890	 
	Shares issued in October 2019 financing	 	 	2,407,314	 	 	 	-	 
	Shares issued in March 2020 financing	 	 	431,870	 	 	 	-	 
	Weighted average shares outstanding, end of year	 	 	31,899,640	 	 	 	25,674,027	 
	Common shares issued and outstanding, end of year	 	 	46,799,828	 	 	 	28,578,137	 

 

The effect
of any potential exercise of the Company's stock options and warrants outstanding during the period has been excluded from the
calculation of diluted loss per common share as it would be anti-dilutive.

 

		9.	Warrants

 

Year ended March 31,
2020

 

As part of the public offering
closed on March 17, 2020, 790,323 broker warrants were issued, exercisable at $3.10 per share at any time up to March 17,
2022 and with a fair value of $456,016.

 

As part of the public offering
closed on October 17, 2019, 2,653,846 warrants and 350,134 broker warrants were issued, exercisable at $1.75 and $1.30 per
share respectively at any time up to October 17, 2022 and 2021 with a fair value of $705,218 and $105,390 respectively.

 

    14

     

    

 

Medicenna Therapeutics
Corp.

Notes to the consolidated
financial statements

For the Years Ended
March 31, 2020 and 2019

(Expressed in Canadian
Dollars)

 

 

		9.	Warrants cont’d

 

Year ended March 31,
2019

 

As part of the short-form prospectus
offering closed on December 21, 2018, 2,000,000 warrants and 280,000 broker warrants were issued, exercisable at $1.20 per
share at any time up to December 21, 2023 and with a fair value of $1,042,861 and $91,000 respectively.

 

Warrant continuity:

 

	 	 	Number of 
 Warrants	 	 	Weighted average
 exercise price	 
	Balance outstanding at March 31, 2018	 	 	3,074,042	 	 	$	2.00	 
	Warrants expired during the year	 	 	(208,959	)	 	 	2.00	 
	Common share purchase warrants issued in the Dec. 2018 financing	 	 	2,000,000	 	 	 	1.20	 
	Broker warrants issued in the Dec. 2018 financing	 	 	280,000	 	 	 	1.20	 
	Balance outstanding at March 31, 2019	 	 	5,145,083	 	 	$	1.65	 
	Common share purchase warrants issued in the October 2019 financing	 	 	2,653,846	 	 	 	1.75	 
	Broker warrants issued in the financing October 2019 financing	 	 	350,134	 	 	 	1.30	 
	Broker warrants issued in the March 2020 financing	 	 	790,323	 	 	 	3.10	 
	Warrants exercised during the year	 	 	(1,623,675	)	 	 	1.46	 
	Warrants outstanding at March 31, 2020	 	 	7,315,711	 	 	$	1.86	 

 

The following
warrants were exercised during the year ended March 31, 2020:

 

	Number of
 Warrants	 	 	Exercise 
 Price	 	 	 
Proceeds
	 	 	Expiry Date
	 	 	 	$	 	 	$	 	 	 
	 	695,544	 	 	 	1.75	 	 	 	1,217,202	 	 	October 17, 2022
	 	138,631	 	 	 	1.30	 	 	 	180,220	 	 	October 17, 2021
	 	35,000	 	 	 	2.00	 	 	 	70,000	 	 	April 5, 2021
	 	222,500	 	 	 	1.20	 	 	 	267,000	 	 	December 21, 2020
	 	532,000	 	 	 	1.20	 	 	 	638,400	 	 	December 21, 2023
	 	1,623,675	 	 	 	 	 	 	 	2,372,822	 	 	 

 

The fair values of warrants are
estimated using the Black-Scholes option-pricing model. The following assumptions were used to determine the fair value of warrants
issued in the following years:

 

	 	 	March 31, 2020	 	 	March 31, 2019	 
	Risk free interest rate	 	 	1.5	%	 	 	3.0	%
	Expected life of options	 	 	1-1.5 years 	 	 	 	2.0-2.5 years 	 
	Expected volatility	 	 	70-78%	 	 	 	85	%
	Expected dividend yield	 	 	-	 	 	 	-	 
	Weighted average fair value of options granted during the year	 	$	0.33	 	 	$	0.37	 

 

    15

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian Dollars) 

 

 

		9.	Warrants cont’d

 

At March 31,
2020, warrants were outstanding and exercisable, enabling holders to acquire common shares as follows:

 

	Number of 
 Warrants	 	 	Exercise
 Price	 	 	Expiry Date
	 	 	 	$	 	 	 
	 	57,500	 	 	 	1.20	 	 	December 21, 2020
	 	1,379,083	 	 	 	2.00	 	 	January 1, 2021
	 	1,288,000	 	 	 	2.00	 	 	March 1, 2021
	 	163,000	 	 	 	2.00	 	 	April 5, 2021
	 	211,503	 	 	 	1.30	 	 	October 17, 2021
	 	790,323	 	 	 	3.10	 	 	March 17, 2022
	 	1,958,302	 	 	 	1.75	 	 	October 17, 2022
	 	1,468,000	 	 	 	1.20	 	 	December 21, 2023
	 	7,315,711	 	 	 	 	 	 	 

 

		10.	Stock options

 

Year ended March 31,
2020

 

During
the year ended March 31, 2020 the Company granted 1,030,000 stock options exercisable at $1.30 per share. Of these options,
300,000 vest 50% upon issuance and 50% after one year and have a five year life. 730,000 options vest 50% after one year, 25% after
2 years and 25% after 3 years and have a ten year life.

 

200,000 options were also issued,
exercisable at $1.38 per share. 50,000 of the options granted vest 50% after one year, 25% after two years and 25% after three
years, 150,000 of the options vest 50% on September 1, 2019 and 50% on December 1, 2019 and have a ten-year life.

 

Year ended March 31,
2019

 

During the year ended
March 31, 2019 the Company granted 200,000 stock options exercisable at $1.09 per share, with a 5-year life. The options
vested 25% on issue on September 1, 2018, 25% on December 1, 2018, 25% on March 1, 2019 and 25% on
June 1, 2019. The Company granted an additional 1,175,000 options on February 14, 2019 at an exercise price of
$1.00. 200,000 of these options vested 50% immediately and 50% will vest on February 14, 2020. These options have a
5-year life. The remaining 975,000 options vest 50% after one year, 25% after two years and 25% after three years and have a
ten-year life.

 

Stock option
transactions for the years ended March 31, 2020 are set forth below:

 

	 	 	Number of 
 options	 	 	Weighted
 average
 exercise
 price	 
	Balance outstanding at March 31, 2018	 	 	2,175,000	 	 	$	2.11	 
	Forfeited	 	 	(275,000	)	 	 	2.40	 
	Granted	 	 	1,375,000	 	 	$	1.00	 
	Balance outstanding at March 31, 2019	 	 	3,275,000	 	 	$	1.67	 
	Granted	 	 	1,230,000	 	 	$	1.38	 
	Forfeited	 	 	(375,000	)	 	 	1.09	 
	Balance outstanding at March 31, 2020	 	 	4,130,000	 	 	$	1.56	 

 

    16

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian
Dollars)

 

  

		10.	Stock options – cont’d

 

The following
table summarizes information about stock options outstanding at March 31, 2020:

 

	 	 	 	Options Outstanding	 	 	Options Exercisable	 
	Exercise
 Prices	 	 	Options	 	 	Weighted average
 remaining
 contractual life	 	 	Weighted
 average 
 exercise price	 	 	Options	 	 	Weighted 
 average
 exercise price	 
	$	 	 	 	 	 	Years	 	 	$	 	 	 	 	 	$	 
	 	0.00-1.00	 	 	 	1,150,000	 	 	 	8.12	 	 	 	1.00	 	 	 	662,500	 	 	 	1.00	 
	 	1.01-1.50	 	 	 	1,230,000	 	 	 	8.32	 	 	 	1.31	 	 	 	300,000	 	 	 	1.34	 
	 	1.51-2.00	 	 	 	950,000	 	 	 	6.88	 	 	 	2.00	 	 	 	712,500	 	 	 	2.00	 
	 	2.01-2.88	 	 	 	800,000	 	 	 	6.26	 	 	 	2.23	 	 	 	650,000	 	 	 	2.28	 
	 	 	 	 	 	4,130,000	 	 	 	7.54	 	 	 	1.56	 	 	 	2,325,000	 	 	 	1.71	 

 

The
following assumptions were used in the Black-Scholes option-pricing model to determine the fair value of stock options
granted during the year:

 

	 	 	March 31, 2020	 	 	March 31, 2019	 
	Exercise price	 	 	$1.30-1.38 	 	 	 	$1.00-1.09 	 
	Grant date share price	 	 	$1.30-1.38	 	 	 	$0.80- 1.09 	 
	Risk free interest rate	 	 	1.5	%	 	 	1.5 - 3.0%  	 
	Expected life of options	 	 	2.5-5 years 	 	 	 	2.5-5 years 	 
	Expected volatility	 	 	100-114%	 	 	 	100-116%	 
	Expected dividend yield	 	 	-	 	 	 	-	 
	Forfeiture rate	 	 	 	 	 	 	0-15%	 
	Weighted average fair value of options granted during the period	 	$	0.94	 	 	$	0.61	 

 

		11.	Government assistance

 

CPRIT assistance

 

In February 2015, the Company
received notice that it had been awarded a grant by the Cancer Prevention Research Institute of Texas (“CPRIT”) whereby
the Company is eligible to receive up to US$14,100,000 on eligible expenditures over a three year period related to the development
of the Company’s phase 2b clinical program for MDNA55. In October 2017 the Company was granted a one year extension
to the grant allowing expenses to be claimed over a four year period ending February 28, 2019. On February 4, 2019 the
Company was approved for a further six month extension ending August 31, 2019, on July 25, 2019 an additional six month
extension was granted to February 28, 2020 and on January 6, 2020 an additional six month extension was granted to August 28,
2020.

 

Of the US$14.1 million grant
approved by CPRIT, Medicenna has received US$12.7 million from CPRIT as of March 31, 2020. The Company is eligible to receive
the remaining US$1.4 million upon the achievement of certain criteria as determined by CPRIT, from time to time. There can be no
assurances that the balance of such grants will be received from CPRIT.

 

Ongoing program funding from
CPRIT is subject to a number of conditions including the satisfactory achievement of milestones that must be met to release additional
CPRIT funding, proof the Company has raised 50% matching funds and maintaining substantial functions of the Company related to
the project grant in Texas as well as using Texas-based subcontractor and collaborators wherever possible. There can be no assurances
that the Company will continue to meet the necessary CPRIT criteria, satisfactorily achieve milestones, or that CPRIT will continue
to advance additional funds to the Company.

 

    17

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian
Dollars)

 

  

		11.	Government assistance – cont’d

 

If the Company is found to have
used any grant proceeds for purposes other than intended, is in violation of the terms of the grant, or relocates its MDNA55 related
operations outside of the state of Texas, then the Company is required to repay any grant proceeds received.

 

Under the terms of the grant,
the Company is also required to pay a royalty to CPRIT, comprised of 3-5% of revenues on net sales of MDNA55 until aggregate royalty
payments equal 400% of the grant funds received at which time the ongoing royalty will be 0.5%.

 

During the year ended March 31,
2020, the Company received $3,539,465 from CPRIT (2019 - $3,242,073).

 

		12.	Commitments

 

Intellectual Property

 

On August 21, 2015,
the Company exercised its right to enter into two license agreements (the “Stanford License Agreements”) with the
Board of Trustees of the Leland Stanford Junior University (“Stanford”). In connection with this licensing
agreement the Company issued 649,999 common shares with a value of $98,930 to Stanford and affiliated inventors. The value of
these shares has been recorded as an intangible asset that is being amortized over the life of the underlying patents. As at
March 31, 2020, the Company’s intangible assets have a remaining capitalized netbook value of $76,259
(March 31, 2019 - $81,205).

 

The development milestones under
the Stanford License Agreements were updated during the year ended March 31, 2020 to reflect the current stage of development
of the Company’s programs. In connection with the amendment of the Stanford License Agreements, Medicenna paid a US$150,000
fee to Leland Stanford Junior University.

 

The Company has entered into
various license agreements with respect to accessing patented technology. In order to maintain these agreements, the Company is
obligated to pay certain costs based on timing or certain milestones within the agreements, the timing of which is uncertain. These
costs include ongoing license fees, patent prosecution and maintenance costs, royalty and other milestone payments. As at March 31,
2020, the Company is obligated to pay the following:

 

		•	Patent licensing costs
due within 12 months totaling $70,500.

		•	Patent licensing costs,
including the above, due within the next five years totaling $1,283,100.

		•	Given the current development plans and expected timelines of the Company it is assumed that a project milestones of US$50,000
and US$100,000 will be due in the next five years.

		•	Project milestone payments,
assuming continued success in the development programs, of uncertain timing
totaling US$2,650,000 and an additional US$2,000,000 in sales milestones.

		•	A liquidity payment of $370,375 is due to the National Institute of Health (“NIH”) which represents the remaining
payments resulting from the Company’s liquidity event in March 2017.

 

	Contractual obligations	 	Less than 
 1 year	 	 	1-3 years	 	 	3-5 years	 	 	Total	 
	Patent licensing costs, minimum annual royalties per license agreements	 	$	70,500	 	 	$	465,300	 	 	$	747,300	 	 	$	1,283,100	 
	Lease payments	 	$	41,460	 	 	$	38,005	 	 	$	0	 	 	$	79,465	 
	Liquidity event payment	 	$	370,375	 	 	$	0	 	 	$	0	 	 	$	370,375	 

 

As at March 31, 2020, the
Company had obligations to make future payments, representing significant research and development and manufacturing contracts
and other commitments that are known and committed in the amount of approximately $5,740,000. Most of these agreements are cancellable
by the Company with notice. These commitments include agreements for manufacturing and preclinical studies.

 

    18

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian
Dollars)

 

  

		13.	Related party disclosures

 

		(a)	Key management personnel

 

Key management personnel, which
consists of the Company’s officers (President and Chief Executive Officer, Chief Financial Officer, and Chief Development
Officer) and directors, earned the following compensation for the following periods:

 

	 	 	2020	 	 	2019	 
	 	 	$	 	 	$	 
	Salaries and wages	 	 	891,747	 	 	 	891,748	 
	Board fees	 	 	142,264	 	 	 	141,466	 
	Stock option expense	 	 	872,585	 	 	 	786,121	 
	Related party rent and moving expenses	 	 	64,561	 	 	 	21,515	 
	 	 	 	1,977,157	 	 	 	1,840,850	 

 

During the year ended March 31,
2020, the Company paid $64,561 (2019: $21,515) in moving, storage and rent expenses to the CEO and CDO of the Company. These transactions
were in the normal course of business and have been measured at the exchange amount, which is the amount of consideration established
and agreed to by the related parties.

 

		(b)	Amounts payable to related parties

 

As at March 31, 2020, the
Company had trade and other payables in the normal course of business, owing to directors and officers of $247,696 (2019: $380,328)
related to board fees and accrued vacation.

 

		14.	Income taxes

 

a) Provision for Income Tax

 

A reconciliation of income taxes
at statutory rates with the reported taxes is as follows:

 

	 	 	2020	 	 	2019	 
	 	 	$	 	 	$	 
	Loss before income taxes	 	 	(8,277,069	)	 	 	(4,708,031	)
	Tax rate	 	 	27.0	%	 	 	27.0	%
	Expected tax recovery	 	 	(2,235,000	)	 	 	(1,271,000	)
	 	 	 	 	 	 	 	 	 
	Change in statutory rates and foreign exchange rates	 	 	35,000	 	 	 	(9,000	)
	Permanent differences	 	 	309,000	 	 	 	270,000	 
	Share issuance costs	 	 	(993,000	)	 	 	(149,000	)
	Change in unrecognized deductible temporary difference	 	 	2,884,000	 	 	 	1,159,000	 
	Total income tax expense (recovery)	 	 	-	 	 	 	-	 

 

    19

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian
Dollars)

 

  

		14.	Income taxes cont’d

 

b) Deferred Income Tax

 

The significant components of the Company’s
deferred tax assets that have not been included on the consolidated statement of financial position are as follows:

 

	 	 	2020	 	 	2019	 
	 	 	 	$	 	 	 	$	 
	Non-capital losses carry-forward	 	 	6,287,000	 	 	 	4,299,000	 
	Property and equipment	 	 	50,000	 	 	 	50,000	 
	Share issuance costs	 	 	940,000	 	 	 	249,000	 
	 	 	 	7,277,000	 	 	 	4,393,000	 
	Unrecognized deferred tax asset	 	 	(7,277,000	)	 	 	(4,393,000	)
	Net deferred tax assets	 	 	-	 	 	 	-	 

 

The significant components of
the Company’s temporary differences, unused tax credits and unused tax losses that have not been included in the consolidated
statements of financial position are as follows:

 

	Type	 	Amount	 	 	Expiry
	Non-capital losses carry-forward	 	$	24,017,000	 	 	2034-2040
	Property and equipment	 	 	186,000	 	 	N/A
	Share issuance costs	 	 	3,480,000	 	 	2038-2041

 

		15.	Components of Expenses

 

	 	 	2020	 	 	2019	 
	 	 	$	 	 	$	 
	General and Administration Expenses	 	 	 	 	 	 	 	 
	   Depreciation expense	 	 	7,893	 	 	 	6,818	 
	   Stock based compensation	 	 	638,556	 	 	 	563,180	 
	   Facilities and operations	 	 	252,716	 	 	 	162,995	 
	   Legal, professional and finance	 	 	186,026	 	 	 	166,277	 
	   Salaries and benefits	 	 	595,588	 	 	 	676,952	 
	   Corporate communications	 	 	559,089	 	 	 	368,199	 
	   Other expenses	 	 	260,715	 	 	 	271,054	 
	   CPRIT grant claimed in eligible expenses (Note 11)	 	 	(125,372	)	 	 	(506,188	)
	 	 	 	2,375,211	 	 	 	1,709,286	 

 

    20

     

    

 

Medicenna Therapeutics Corp.

Notes to the consolidated financial statements

For the Years Ended March 31, 2020 and 2019

(Expressed in Canadian
Dollars)

 

  

		15.	Components of Expenses cont’d

 

	 	 	2020	 	 	2019	 
	 	 	$	 	 	$	 
	Research and Development Expenses	 	 	 	 	 	 	 	 
	   Chemistry, manufacturing and controls	 	 	342,578	 	 	 	399,994	 
	   Regulatory	 	 	432,948	 	 	 	48,105	 
	   Discovery and pre-clinical	 	 	1,898,191	 	 	 	805,477	 
	   Research and development warrant	 	 	-	 	 	 	710,574	 
	   Clinical	 	 	1,528,229	 	 	 	3,710,789	 
	   Salaries and benefits	 	 	1,095,118	 	 	 	1,190,142	 
	   Licensing, patent, legal fees and royalties	 	 	810,987	 	 	 	783,458	 
	   Stock based compensation	 	 	486,421	 	 	 	435,439	 
	   CPRIT grant claimed in eligible expenses (Note 11)	 	 	(951,166	)	 	 	(5,140,039	)
	   Other research and development expenses	 	 	226,282	 	 	 	74,058	 
	 	 	 	5,869,588	 	 	 	3,017,997	 

 

		16.	Subsequent Events

 

Subsequent
to the year end, the agents fully exercised their over-allotment option to purchase an additional 1,693,548 common shares of
the Company at a price of $3.10 per share, in connection with     the
previous public offering of common shares of Medicenna which was completed on March 17, 2020. As
a result of the exercise of this over-allotment option, Medicenna received additional gross proceeds of
$5,249,999.

 

In March 2020 the World
Health Organization declared coronavirus COVID-19 a global pandemic. This contagious disease outbreak and any related adverse public
health developments may adversely affect workforces, economies, and financial markets globally, potentially leading to an economic
downturn. It is not possible for the Company to predict the duration or magnitude of the adverse results of the outbreak and its
effects on the Company’s business or results of operations at this time.

 

    21

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