Document:

<PAGE>
                                                                    EXHIBIT 10.1

                 SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT

         THIS SECOND AMENDMENT TO LOAN AND SECURITY AGREEMENT (this "Amendment")
is made and entered into on April 15, 2004, by and between HORIZON MEDICAL
PRODUCTS, INC., a Georgia corporation (hereinafter referred to as "Borrower"),
with its chief executive office and principal place of business at One Horizon
Way, Manchester, Georgia 31816, and STANDARD FEDERAL BANK NATIONAL ASSOCIATION,
a national banking association, acting by and through LASALLE BUSINESS CREDIT,
LLC (as successor to LaSalle Business Credit, Inc.), a Delaware limited
liability company, as its agent (hereinafter referred to as "Lender"), with an
office at 135 South LaSalle Street, Chicago, Illinois 60603-4105.

                                    RECITALS:

         Lender and Borrower are parties to a certain Loan and Security
Agreement dated as of March 18, 2002, as amended by that certain First Amendment
to Loan and Security Agreement dated as of December 23, 2002 (as amended at any
time, the "Loan Agreement"), pursuant to which Lender has made certain loans and
other financial accommodations to Borrower.

         The parties desire to amend the Loan Agreement as hereinafter set
forth.

         NOW, THEREFORE, for TEN DOLLARS ($10.00) in hand paid and other good
and valuable consideration, the receipt and sufficiency of which are hereby
severally acknowledged, the parties hereto, intending to be legally bound
hereby, agree as follows:

         1.       DEFINITIONS. All capitalized terms used in this Amendment,
unless otherwise defined herein, shall have the meaning ascribed to such terms
in the Loan Agreement.

         2.       AMENDMENTS TO LOAN AGREEMENT.  The Loan Agreement is hereby
amended as follows:

                  (a)      By deleting Section 10 of the Loan Agreement and by
substituting in lieu thereof the following:

                  10.      TERMINATION; AUTOMATIC RENEWAL.

                           THIS AGREEMENT SHALL BE IN EFFECT FROM THE DATE
                  HEREOF UNTIL MARCH 17, 2005 (THE "ORIGINAL TERM") AND SHALL
                  AUTOMATICALLY RENEW ITSELF FROM YEAR TO YEAR THEREAFTER (EACH
                  SUCH ONE-YEAR RENEWAL BEING REFERRED TO HEREIN AS A "RENEWAL
                  TERM") UNLESS (A) LENDER MAKES DEMAND FOR REPAYMENT PRIOR TO
                  THE END OF THE ORIGINAL TERM OR THE THEN CURRENT RENEWAL TERM;
                  (B) THE DUE DATE OF THE LIABILITIES IS ACCELERATED PURSUANT TO
                  SECTION 16 HEREOF; (C) BORROWER ELECTS TO TERMINATE THIS
                  AGREEMENT AT THE END OF THE ORIGINAL TERM OR AT THE END OF ANY
                  RENEWAL TERM BY GIVING LENDER WRITTEN NOTICE OF SUCH ELECTION
                  AT LEAST NINETY (90) DAYS PRIOR TO THE END OF THE ORIGINAL
                  TERM OR THE THEN CURRENT RENEWAL TERM AND BY PAYING ALL OF THE
                  LIABILITIES IN FULL ON THE LAST DAY OF SUCH TERM; (D) BORROWER
                  ELECTS TO TERMINATE THIS AGREEMENT PRIOR TO THE END OF THE
                  ORIGINAL TERM OR ANY THEN CURRENT RENEWAL TERM BY GIVING
                  LENDER WRITTEN NOTICE OF SUCH ELECTION AT LEAST TEN (10) DAYS
                  PRIOR TO SUCH TERMINATION AND BY PAYING ALL OF THE LIABILITIES
                  IN FULL ON OR PRIOR TO THE DATE OF SUCH TERMINATION; OR (E)
                  LENDER ELECTS TO TERMINATE THIS AGREEMENT ON OR AFTER FEBRUARY
                  1, 2004, AS A RESULT OF A

<PAGE>

                  TERMINATION EVENT. If one or more of the events specified in
                  clauses (a), (b), (c), (d) and (e) occurs, then (i) Lender
                  shall not make any additional Loans on or after the date
                  identified as the date on which the Liabilities are to be
                  repaid; and (ii) this Agreement shall terminate on the date
                  thereafter that the Liabilities are paid in full. At such time
                  as Borrower has repaid all of the Liabilities and this
                  Agreement has terminated, Borrower shall deliver to Lender a
                  release, in form and substance satisfactory to Lender, of all
                  obligations and liabilities of Lender and its officers,
                  directors, employees, agents, parents, subsidiaries and
                  affiliates to Borrower, and if Borrower is obtaining new
                  financing from another lender, Borrower shall deliver such
                  lender's indemnification of Lender, in form and substance
                  satisfactory to Lender, for checks which Lender has credited
                  to Borrower's account, but which subsequently are dishonored
                  for any reason or for automatic clearinghouse or wire
                  transfers not yet posted to Borrower's account. If, during the
                  term of this Agreement, Borrower prepays all of the
                  Liabilities from any source other than income from the
                  ordinary course of operations of Borrower's business and this
                  Agreement is terminated prior to the end of the Original Term
                  or any then current Renewal Term, Borrower agrees to pay to
                  Lender as a prepayment fee, in addition to the payment of all
                  other Liabilities, an amount equal to five-eighths of one
                  percent (5/8%) of the Maximum Loan Limit.

                  (b)      By deleting Section (b) of Schedule 14 to the Loan
Agreement and by substituting in lieu thereof the following:

                  B.       FIXED CHARGE COVERAGE.

                           Borrower shall not permit the ratio of its EBITDA to
                  Fixed Charges for each period set forth below to be less than
                  the ratio set forth below for the corresponding period set
                  forth below, in each case for the immediately preceding four
                  fiscal quarters:

<TABLE>
<CAPTION>
                               Period                                      Ratio
                               ------                                      -----
                  <S>                                                  <C>
                  Fiscal quarter ending December 31, 2002              0.15 to 1.0
                  Fiscal quarter ending March 31, 2003                 0.3 to 1.0
                  Fiscal quarter ending June 30, 2003                  0.3 to 1.0
                  Fiscal quarter ending September 30, 2003             0.3 to 1.0
                  Fiscal quarter ending December 31, 2003              0.50 to 1.0
                  Fiscal quarter ending March 31, 2004                 0.50 to 1.0
                  and each fiscal quarter thereafter
</TABLE>

                  (c)      By deleting Section (c) of Schedule 14 to the Loan
Agreement and by substituting in lieu thereof the following:

                  C.       EBITDA.

                           Borrower shall not permit EBITDA to be less than the
                  amount set forth below as of the date set forth below
                  corresponding thereto, based upon the immediately preceding
                  four fiscal quarters:

<PAGE>

<TABLE>
<CAPTION>
                  Period                                           Amount
                  ------                                           ------
                  <S>                                            <C>
                  December 31, 2002                              $  750,000

                  March 31, 2003                                 $1,350,000

                  June 30, 2003                                  $1,475,000

                  September 30, 2003                             $1,475,000

                  December 31, 2003                              $2,500,000

                  March 31, 2004                                 $2,000,000

                  June 30, 2004                                  $2,000,000

                  September 30, 2004                             $2,000,000

                  December 31, 2004 and each fiscal              $2,250,000
                  quarter thereafter based upon the
                  immediately preceding four
                  fiscal quarters
</TABLE>

                  (d)      By deleting the definition of "Maximum Loan Limit" in
Section 1 of the Loan Agreement and by substituting in lieu thereof the
following:

                           "MAXIMUM LOAN LIMIT" shall mean, at any time, an
                  amount equal to the sum of (i) the Maximum Revolving Loan
                  Limit and (ii) the outstanding principal balance of the Term
                  Loan at such time.

                  (e)      By deleting the definition of "Medtronic" in Section
1 of the Loan Agreement and by substituting in lieu thereof the following:

                           "MEDTRONIC" shall mean Medtronic, Inc., a Minnesota
                  corporation.

                  (f)      By deleting Schedule 11(c) (Loans), Schedule 11(g)
(Litigation), Schedule 11(i) (Affiliate Transactions), and Schedule 11(n)
(Indebtedness) to the Loan Agreement in their entirety and by substituting in
lieu thereof, respectively, Schedule 11(c), Schedule 11(g), Schedule 11(i), and
Schedule 11(n) attached to this Amendment.

         3.       RATIFICATION AND REAFFIRMATION. Borrower hereby ratifies and
reaffirms the Liabilities, the Loan Agreement, each of the Other Agreements and
all of Borrower's covenants, duties, indebtedness and liabilities under the Loan
Agreement and the Other Agreements.

         4.       ACKNOWLEDGMENTS AND STIPULATIONS. Borrower acknowledges and
stipulates that the Loan Agreement and the Other Agreements executed by Borrower
are legal, valid and binding obligations of Borrower that are enforceable
against Borrower in accordance with the terms thereof; all of the Liabilities
are owing and payable without defense, offset or counterclaim (and to the extent
there exists any such defense, offset or counterclaim on the date hereof, the
same is hereby waived by Borrower); the security interests and liens granted by
Borrower in favor of Lender are duly perfected, first priority security
interests and liens; the unpaid principal amount of the Revolver Loans on and as
of March 31, 2004, totaled Zero Dollars ($0); and the unpaid principal amount of
the Term Loan on and as of March 31, 2004, totaled Six Hundred Sixty-Six
Thousand Six Hundred Sixty-Six and 56/100 Dollars ($666,666.56).

         5.       REPRESENTATIONS AND WARRANTIES. Borrower represents and
warrants to Lender, to induce Lender to enter into this Amendment, that no
Default or Event of Default exists on the date hereof; the execution, delivery
and performance of this Amendment have been duly authorized by all requisite
corporate action on the part of Borrower and this Amendment has been duly
executed and delivered by Borrower; and all of the representations and

<PAGE>

warranties made by Borrower in the Loan Agreement, as hereby amended, are true
and correct on and as of the date hereof.

         6.       REFERENCE TO LOAN AGREEMENT. Upon the effectiveness of this
Amendment, each reference in the Loan Agreement to "this Agreement,"
"hereunder," or words of like import shall mean and be a reference to the Loan
Agreement, as amended by this Amendment.

         7.       BREACH OF AMENDMENT. This Amendment shall constitute an Other
Agreement under the Loan Agreement and shall be entitled to all benefits and
protections thereof.

         8.       CONDITIONS PRECEDENT. The effectiveness of the amendments
contained in Section 2 hereof is subject to the satisfaction of each of the
following conditions precedent, in form and substance satisfactory to Lender,
unless satisfaction thereof is specifically waived in writing by Lender:

         (a)      Lender shall have received an original counterpart of this
Amendment, duly executed by Borrower and acknowledged by each Guarantor; and

         (b)      Lender shall received a duly executed Secretary's Certificate
of Board of Directors Resolutions authorizing Borrower to enter into this
Amendment.

         9.       AMENDMENT FEE; EXPENSES OF LENDER. In consideration of
Lender's willingness to enter into this Amendment, Borrower agrees to pay to
Lender an amendment fee in the amount of $25,000 in immediately available funds
on the date hereof. Additionally, Borrower agrees to pay, ON DEMAND, all costs
and expenses incurred by Lender in connection with the preparation, negotiation
and execution of this Amendment and any Other Agreements executed pursuant
hereto and any and all amendments, modifications, and supplements thereto,
including, without limitation, the costs and fees of Lender's legal counsel and
any taxes or expenses associated with or incurred in connection with any
instrument or agreement referred to herein or contemplated hereby.

         10.      EFFECTIVENESS; GOVERNING LAW. This Amendment shall be
effective upon acceptance by Lender in Atlanta, Georgia (notice of which
acceptance Borrower hereby waives), whereupon the same shall be governed by and
construed in accordance with the internal laws of the State of Georgia.

         11.      SUCCESSORS AND ASSIGNS. This Amendment shall be binding upon
and inure to the benefit of the parties hereto and their respective successors
and assigns.

         12.      NO NOVATION, ETC. Except as otherwise expressly provided in
this Amendment, nothing herein shall be deemed to amend or modify any provision
of the Loan Agreement or any of the Other Agreements, each of which shall remain
in full force and effect. This Amendment is not intended to be, nor shall it be
construed to create, a novation or accord and satisfaction, and the Loan
Agreement as herein modified shall continue in full force and effect.

         13.      COUNTERPARTS; TELECOPIED SIGNATURES. This Amendment may be
executed in any number of counterparts and by different parties to this
Amendment on separate counterparts, each of which, when so executed, shall be
deemed an original, but all such counterparts shall constitute one and the same
agreement. Any signature delivered by a party by facsimile transmission shall be
deemed to be an original signature hereto.

         14.      FURTHER ASSURANCES. Borrower agrees to take such further
actions as Lender shall reasonably request from time to time in connection
herewith to evidence or give effect to the amendments set forth herein or any of
the transactions contemplated hereby.

         15.      SECTION TITLES. Section titles and references used in this
Amendment shall be without substantive meaning or content of any kind whatsoever
and are not a part of the agreements among the parties hereto.

         16.      WAIVER OF JURY TRIAL. TO THE FULLEST EXTENT PERMITTED BY
APPLICABLE LAW, THE PARTIES HERETO EACH HEREBY WAIVES THE RIGHT TO TRIAL BY JURY
IN ANY ACTION, SUIT, COUNTERCLAIM OR PROCEEDING ARISING OUT OF OR RELATED TO
THIS AMENDMENT.

                         [Signatures on following page]

<PAGE>

IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be duly
executed under seal and delivered by their respective duly authorized officers
as of the date first written above.

ATTEST:                               HORIZON MEDICAL PRODUCTS, INC.
                                      ("Borrower")

  /s/ L. Bruce Maloy            By:        /s/ Robert J. Wenzel
------------------------            --------------------------------
Secretary                                      Robert J. Wenzel
                                               President

[CORPORATE SEAL]

                                      STANDARD FEDERAL BANK NATIONAL
                                      ASSOCIATION, acting by and through
                                      LASALLE BUSINESS CREDIT, LLC, as its agent
                                      ("Lender")

                                      By:      /s/ Patrick Aarons
                                          --------------------------------------

                                      Title:   First Vice President
                                            ------------------------------------<PAGE>
                    GUARANTEED MINIMUM ACCOUNT VALUE ("GMAV")
                                   ENDORSEMENT

Notwithstanding any provision in the Contract or Certificate ("Contract") to the
contrary, this Endorsement becomes a part of the Contract to which it is
attached. Should any provision in this Endorsement conflict with the Contract,
the provisions of this Endorsement will prevail.

EFFECTIVE DATE: [DATE]

GMAV DATE: [DATE]

                                   DEFINITIONS

EFFECTIVE DATE
The date shown above when this Endorsement becomes effective. If this
Endorsement is elected at Contract issue, the Effective Date is the date Your
Contract is issued. If this Endorsement is elected after Your Contract is
issued, the Effective Date is the [Contract Anniversary] following receipt of
Your written election, in good order as defined by Us, at Our Annuity Service
Center.

GMAV BASE
The basis that is used to determine the GMAV Benefit (as described below). The
GMAV Base is calculated from the Effective Date of this Endorsement to the GMAV
Date. After the GMAV Date there is no GMAV Base as described in this
Endorsement.

THE GMAV BASE IS USED SOLELY FOR THE PURPOSE OF CALCULATING THE GMAV BENEFIT AND
DOES NOT PROVIDE A CONTRACT VALUE OR GUARANTEE PERFORMANCE OF ANY INVESTMENT
OPTION.

GMAV BENEFIT
The benefit provided by this Endorsement is the amount added to the Contract
Value on the GMAV Date. This amount, if any, will be allocated on the GMAV Date
to a variable investment option(s) as determined by the Company. The GMAV
Benefit is not considered a Premium or Purchase Payment ("Purchase Payment").
The GMAV Benefit has no value on any date other than on the GMAV Date.

GMAV DATE
The date, shown above, on which the GMAV Benefit is calculated and added to Your
Contract Value.

SPOUSAL BENEFICIARY
Your spouse, if designated as Your primary Beneficiary on the date of Your
death, who elects to continue the Contract as the new Owner ("Owner") upon Your
death.

                                 GMAV PROVISIONS

This Endorsement provides a GMAV Benefit subject to the terms and conditions
described herein. On the GMAV Date, if the GMAV Base is greater than the
Contract Value, We will add the GMAV Benefit to Your Contract Value.

GMAV CHARGE
The charge deducted from Your Contract Value on a quarterly basis beginning one
Contract quarter following the Effective Date of this Endorsement. A full
quarterly charge will also be deducted on the GMAV Date. The GMAV Charge will
not be deducted after the GMAV Date.

<TABLE>
<CAPTION>
    Years Since Effective Date            Annualized GMAV Charge Percentage
    --------------------------            ---------------------------------
<S>                                       <C>
              [0-5]                                    [0.60%]
              [6-10]                                   [0.35%]
              [11+]                                    [0.00%]
</TABLE>

The GMAV Charge deducted on a quarterly basis is calculated as one-fourth of the
Annualized GMAV Charge Percentage applied to any positive difference between the
Contract Value and any Purchase Payments made more than [90 days] since the
Effective Date.

                                       1
<PAGE>
CALCULATION OF THE GMAV BASE AND GMAV BENEFIT
The GMAV Base on any date following the Effective Date, up to and including the
GMAV Date, is equal to (a) or (b) minus (c) where:

      (a)   is, if the GMAV Benefit is elected at Contract issue, the first
            Purchase Payment received on the Effective Date and any subsequent
            Purchase Payments multiplied by the percentage as specified in the
            table below;

      (b)   is, if this GMAV Benefit is elected after Contract issue, the
            Contract Value on the Effective Date and any subsequent Purchase
            Payments multiplied by the percentage as specified in the table
            below;

      (c)   is a proportional adjustment for each partial withdrawal (including
            any charges on each such withdrawal) taken subsequent to the
            Effective Date. A proportional adjustment is the GMAV Base
            immediately prior to a withdrawal multiplied by the percentage by
            which the Contract Value is reduced at the time of that withdrawal.

If the GMAV Base is greater than the Contract Value on the GMAV Date, the GMAV
Benefit is calculated as the difference between the GMAV Base and the Contract
Value on the GMAV Date. If the GMAV Base is less than the Contract Value on the
GMAV Date, no benefit is added to the Contract Value.

The table below is used for purposes of calculating the GMAV Base as determined
by the time elapsed since the Effective Date of this Endorsement and the day on
which Purchase Payments are received by Us and applied to Your Contract. If this
benefit is elected after Your Contract is issued, the Contract Value on the
Effective Date of the Endorsement is considered a Purchase Payment for purposes
of calculating the GMAV Base and charges.

<TABLE>
<CAPTION>
TIME ELAPSED SINCE EFFECTIVE DATE    PERCENTAGE INCLUDED IN THE GMAV CALCULATION
---------------------------------    -------------------------------------------
<S>                                  <C>
        [0-[90] Days]                                 [100%]
      [91 Days to 1 Year]                               [0%]
      [More than 1 Year]                                [0%]
</TABLE>

SPOUSAL CONTINUATION
If Your Spousal Beneficiary elects to continue the Contract prior to the GMAV
Date, the Spousal Beneficiary cannot terminate the GMAV Benefit. All of the
terms and conditions of the Endorsement will remain inforce. The Effective Date
and the GMAV Date, as shown on page one of this Endorsement, will not change as
a result of Spousal Continuation.

TERMINATION
Once elected and prior to the GMAV Date, this Endorsement and its corresponding
charge cannot be terminated unless one of the following occurs:

      (a)   A Death Benefit is paid (as described under the Death Provisions
            section of Your Contract); or

      (b)   The Contract is fully withdrawn; or

      (c)   The Contract is annuitized.

Absent the occurrence of one of the above, this Endorsement terminates on the
GMAV Date.

Signed for the Company on the Effective Date.

FIRST SUNAMERICA LIFE INSURANCE COMPANY

/s/ Christine A. Nixon                         /s/ Jana W. Greer
---------------------------------              ---------------------------------
      Christine A. Nixon                                  Jana W. Greer
          Secretary                                         President

                                       2

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