Document:

Exhibit 10.10  

July    ,
2003 

EarlyBirdCapital, Inc.

600 Third Avenue

33rd Floor

New York, New York 10016 

	Re:
	Millstream Acquisition Corporation

Gentlemen: 

        This
letter will confirm the agreement of the undersigned to purchase warrants ("Warrants") of Millstream Acquisition Corporation ("Company") included in the units ("Units") being sold
in the Company's initial public offering ("IPO") upon the terms and conditions set forth herein. Each Unit is comprised of one share of Common Stock and two Warrants. The shares of Common Stock and
Warrants will not be separately tradeable until 90 days after the effective date of the Company's IPO unless EarlyBirdCapital, Inc. ("EBC") informs the Company of its decision to allow
earlier separate trading ("Separation Date"). 

        The
undersigned agrees that this letter agreement constitutes an irrevocable order for EBC to purchase for his account during the ten-day period commencing on the Separation
Date up to 1,000,000 Warrants at market prices not to exceed $0.65 per Warrant ("Maximum Warrant Purchase"). EBC agrees to fill such order in such amounts and at such times as it may determine, in its
sole discretion, during the ten-day period commencing on the Separation Date. The undersigned may notify EBC that all or part of his Maximum Warrant Purchase will be made by an affiliate
of the undersigned (or another person or entity introduced to EBC by the undersigned (a "Designee")) who (or which) has an account at EBC and, in such event, EBC will make such purchase on behalf of
said affiliate or Designee; provided, however, that the undersigned hereby agrees to make payment of the purchase price of such purchase in the event that the affiliate or Designee fails to make such
payment. 

	 	 	Very truly yours,
	

 	
 	

 
	

 	
 	

 Arthur SpectorExhibit 10.11  

June    ,
2003 

Millstream
Acquisition Corporation

c/o Arthur Spector

435 Devon Park Drive

Building 400

Wayne, Pennsylvania 19087 

EarlyBirdCapital, Inc.

600 Third Avenue

33rd Floor

New York, New York 10016 

	Re:
	Insider Letters

Gentlemen:

        Each
of the undersigned hereby confirm that: 

        1.     Section 10
of the letter agreements, dated May 9, 2003, among Millstream Acquisition Corporation ("Company"), EarlyBirdCapital, Inc. ("EBC") and each
of Arthur Spector, Dr. Heinz C. Schimmelbusch, Robert E. Keith, Jr. and Don K. Rice and Section 9 of the letter agreements, dated May 9, 2003, among the Company, EBC and each of
the Spector Family Trust and J. Brian O'Neill, relating to the right of first refusal granted to EBC by the undersigned for public sales, is hereby deleted in its entirety; and 

        2.     The
last proviso of Section 6 of the letter agreements, dated May 9, 2003, among the Company, EBC and each of Arthur Spector, Dr. Heinz C.
Schimmelbusch, Robert E. Keith, Jr. and Don K. Rice and the last proviso of Section 5 of the letter agreements, dated May 9, 2003, among the Company, EBC and each of the Spector Family
Trust and J. Brian O'Neill, is hereby deleted in its entirety such that Section 6 and Section 5 read as follows, respectively; 

"The
undersigned will not be entitled to receive and will not accept a finder's fee or any other compensation in the event the undersigned originates a Business Combination." 

	

 Arthur Spector	
 	

 Dr. Heinz C. Schimmelbusch
	

 	

 	
 	

 	

 
	
 Robert E. Keith, Jr,	 	
 Don K. Rice
	

 	

 	
 	

 	

 
	 	 	 	SPECTOR FAMILY TRUST
	

 	

 	
 	

 	

 
	 	 	 	By:	 
	
 J. Brian O'Neill	 	 	
 Adam B. Spector, Trustee
	

 	

 	
 	

 	

 
	 	 	 	By:	 
	 	 	 	 	
 Jeremy D. Spector, Trustee
	

 	

 	
 	

 	

 
	 	 	 	 	 

	Accepted and Agreed:	 	 	 
	

 	

 	
 	

 	

 
	MILLSTREAM ACQUISITION CORPORATION	 	 	 
	

 	

 	
 	

 	

 
	By:	 	 	 	 
	 	
 Arthur Spector, Chairman	 	 	 
	

 	

 	
 	

 	

 
	EARLYBIRDCAPITAL, INC.	 	 	 
	

 	

 	
 	

 	

 
	By:	 	 	 	 
	 	
 Steven Levine, ChairmanQuickLinks
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Exhibit 10.1  

 
 

BIOSITE INCORPORATED
  AMENDED AND RESTATED
  STOCK INCENTIVE PLAN
  
    Effective June 18, 2003    
    

ARTICLE 1    INTRODUCTION.  

        The Plan was adopted by the Board on December 5, 1996, and was approved by the Company's stockholders on December 6, 1996. The Plan is effective
December 1, 1996. However, Articles 7, 8 and 9 shall not apply prior to the Company's initial public offering. On February 27, 1998, the Plan was amended by the Board to increase the
number of shares under the Plan. The Plan was amended again on March 26, 1999, January 28, 2000, January 19, 2001, April 17, 2002, and June 18, 2003, to increase the
number of shares available under the Plan, and on April 20, 1999, to remove provisions permitting the repricing of stock options at lower exercise prices, on November 7, 2002, to revise
provisions as to limitations on payments under the Plan, and on October 23, 2002, to adopt provisions applicable to stock options granted to recipients residing in France. 

        The
purpose of the Plan is to promote the long-term success of the Company and the creation of stockholder value by (a) encouraging Key Employees to focus on critical
long-range objectives, (b) encouraging the attraction and retention of Key Employees with exceptional qualifications and (c) linking Key Employees directly to stockholder
interests through increased stock ownership. The Plan seeks to achieve this purpose by providing for Awards in the form of Restricted Shares, Stock Units, Options (which may constitute incentive stock
options or nonstatutory stock options) or stock appreciation rights. 

        The
Plan shall be governed by, and construed in accordance with, the laws of the State of California. 

ARTICLE 2    ADMINISTRATION.  

        2.1   Committee
Composition.    The Plan shall be administered by the Committee. Except as provided below, the Committee shall consist exclusively of directors of
the Company, who shall be appointed by the Board. In addition, the composition of the Committee shall satisfy: 

        (a)   Such
requirements, if any, as the Securities and Exchange Commission may establish for administrators acting under plans intended to qualify for exemption under
Rule 16b-3 (or its successor) under the Exchange Act; and 

        (b)   Such
requirements as the Internal Revenue Service may establish for outside directors acting under plans intended to qualify for exemption under
section 162(m)(4)(C) of the Code. 

The
Board may act on its own behalf with respect to Outside Directors and may also appoint one or more separate committees composed of one or more officers of the Company who need not be directors of
the Company and who need not satisfy the foregoing requirements, who may administer the Plan with respect to Key Employees who are not "covered employees" under section 162(m)(3) of the Code
and who are not required to report pursuant to § 16(a) of the Exchange Act. 

        2.2   Committee
Responsibilities.    The Committee shall (a) select the Key Employees who are to receive Awards under the Plan, (b) determine the
type, number, vesting requirements and other features and conditions of such Awards, (c) interpret the Plan and (d) make all other decisions relating to the operation of the Plan. The
Committee may adopt such rules or guidelines as it deems appropriate to implement the Plan. The Committee's determinations under the Plan shall be final and binding on all persons. 

ARTICLE 3    SHARES AVAILABLE FOR GRANTS.  

        3.1   Basic
Limitation.    Common Shares issued pursuant to the Plan may be authorized but unissued shares or treasury shares. The aggregate number of Common
Shares available for Restricted Shares, Stock Units, Options and SARs awarded under the Plan shall not exceed five million eight hundred thousand (5,800,000). Of the Common Shares available hereunder,
no more than 20% in aggregate shall be available with respect to Outside Directors. The limitation of this Section 3.1 shall be subject to adjustment pursuant to Article 10. The number
of Common Shares available under this Plan shall be increased by unexercised or forfeited Common Shares under the Company's 1989 Stock Plan. 

        3.2   Additional
Shares.    If Stock Units, Options or SARs are forfeited or if Options or SARs terminate for any other reason before being exercised, then the
corresponding Common Shares shall again become available for Awards under the Plan. If Restricted Shares are forfeited before any dividends have been paid with respect to such Shares, then such Shares
shall again become available for Awards under the Plan. If Stock Units are settled, then only the number of Common Shares (if any) actually issued in settlement of such Stock Units shall reduce the
number available under Section 3.1 and the balance shall again become available for Awards under the Plan. If SARs are exercised, then only the number of Common Shares (if any) actually issued
in settlement of such SARs shall reduce the number available under Section 3.1 and the balance shall again become available for Awards under the Plan. 

        3.3   Dividend
Equivalents.    Any dividend equivalents distributed under the Plan shall not be applied against the number of Restricted Shares, Stock Units,
Options or SARs available for Awards, whether or not such dividend equivalents are converted into Stock Units. 

ARTICLE 4    ELIGIBILITY.  

        4.1   General
Rules.    Only Key Employees (including, without limitation, independent contractors who are not members of the Board) shall be eligible for
designation as Participants by the Committee. 

        4.2   Outside
Directors.    The Committee may provide that the NSOs that otherwise would be granted to an Outside Director under this Plan shall instead be granted
to an affiliate of such Outside Director. Such affiliate shall then be deemed to be an Outside Director for purposes of the Plan, provided that the service-related vesting and termination provisions
pertaining to the NSOs shall be applied with regard to the service of the Outside Director. 

        4.3   Incentive
Stock Options.    Only Key Employees who are common-law employees of the Company, a Parent or a Subsidiary shall be eligible for the
grant of ISOs. In addition, a Key Employee who owns more than 10% of the total combined voting power of all classes of outstanding stock of the Company or any of its Parents or Subsidiaries shall not
be eligible for the grant of an ISO unless the requirements set forth in section 422(c)(6) of the Code are satisfied. 

ARTICLE 5    OPTIONS.  

        5.1   Stock
Option Agreement.    Each grant of an Option under the Plan shall be evidenced by a Stock Option Agreement between the Optionee and the Company. Such
Option shall be subject to all applicable terms of the Plan (including any addendum hereto) and may be subject to any other terms that are not inconsistent with the Plan. The Stock Option Agreement
shall specify whether the Option is an ISO or an NSO. The provisions of the various Stock Option Agreements entered into under the Plan need not be identical. Options may be granted in consideration
of a cash payment or in consideration of a reduction in the Optionee's other compensation. A Stock Option Agreement may provide that a new Option will be granted automatically to the Optionee when he
or she exercises a prior Option and pays the Exercise Price in the form described in Section 6.2. 

        5.2   Number
of Shares.    Each Stock Option Agreement shall specify the number of Common Shares subject to the Option and shall provide for the adjustment of such
number in accordance with 

Article 10.
Options granted to any Optionee in a single calendar year shall in no event cover more than 250,000 Common Shares, subject to adjustment in accordance with Article 10. 

        5.3   Exercise
Price.    Each Stock Option Agreement shall specify the Exercise Price; provided that the Exercise Price under an ISO shall in no event be less than
100% of the Fair Market Value of a Common Share on the date of grant and the Exercise Price under an NSO shall in no event be less than the par value of the Common Shares subject to such NSO. In the
case of an NSO, a Stock Option Agreement may specify an Exercise Price that varies in accordance with a predetermined formula while the NSO is outstanding, provided that prior to the Company's initial
public offering, the NSO Exercise Price shall be at least 85% (110% for 10% shareholders) of the Fair Market Value of a Common Share of Stock on the date of grant. 

        5.4   Exercisability
and Term.    Each Stock Option Agreement shall specify the date when all or any installment of the Option is to become exercisable, provided
that prior to the Company's initial public offering, Options shall become exercisable pursuant to a schedule providing for at least 20% vesting per year over a five-year period (or, in the
case of performance options, to the extent permitted under applicable regulations of the California Department of Corporations). The Stock Option Agreement shall also specify the term of the Option,
provided that the term of an ISO shall in no event exceed 10 years from the date of grant. A Stock Option Agreement may provide for accelerated exercisability in the event of the Optionee's
death, disability or retirement or other events and may provide for expiration prior to the end of its term in the event of the termination of the Optionee's service. Notwithstanding the foregoing, no
Options may be accelerated prior to the Company's initial public offering. 

        Options
may be awarded in combination with SARs, and such an Award may provide that the Options will not be exercisable unless the related SARs are forfeited. NSOs may also be awarded in
combination with Restricted Shares or Stock Units, and such an Award may provide that the NSOs will not be exercisable unless the related Restricted Shares or Stock Units are forfeited. 

        Prior
to the Company's initial public offering, Options must be exercised within 30 days of the termination of employment (six months for termination on account of death or
disability). 

        5.5   Effect
of Change in Control.    The Committee may determine, at the time of granting an Option or thereafter, that such Option shall become fully exercisable
as to all Common Shares subject to such Option in the event that a Change in Control occurs with respect to the Company. 

        5.6   Modification
or Assumption of Options.    Within the limitations of the Plan, the Committee may modify, extend or assume outstanding options or may accept
the cancellation of outstanding options (whether granted by the Company or by another issuer) in return for the grant of new options for the same or a different number of shares and at the same or
different exercise price; provided, however, that with respect to the shares subject to the new Option, there shall be no decrease in the aggregate exercise price of such shares, determined on an
adjusted basis. The foregoing notwithstanding, no modification of an Option shall, without the consent of the Optionee, alter or impair his or her rights or obligations under such Option. 

        5.7   Other
Requirements Prior to Company's Initial Public Offering.    Prior to the Company's initial public offering, Optionees shall receive Company financial
statements at least annually. 

ARTICLE 6    PAYMENT FOR OPTION SHARES.  

        6.1   General
Rule.    The entire Exercise Price of Common Shares issued upon exercise of Options shall be payable in cash at the time when such Common Shares are
purchased, except as follows: 

        (a)   In
the case of an ISO granted under the Plan, payment shall be made only pursuant to the express provisions of the applicable Stock Option Agreement. The Stock Option
Agreement may specify that payment may be made in any form(s) described in this Article 6. 

        (b)   In
the case of an NSO, the Committee may at any time accept payment in any form(s) described in this Article 6. 

        6.2   Surrender
of Stock.    To the extent that this Section 6.2 is applicable, payment for all or any part of the Exercise Price may be made with Common
Shares which have already been owned by the Optionee for more than six months. Such Common Shares shall be valued at their Fair Market Value on the date when the new Common Shares are purchased under
the Plan. 

        6.3   Exercise/Sale.    To
the extent that this Section 6.3 is applicable, payment may be made by the delivery (on a form prescribed by the Company) of an
irrevocable direction to a securities broker approved by the Company to sell Common Shares and to deliver all or part of the sales proceeds to the Company in payment of all or part of the Exercise
Price and any withholding taxes. 

        6.4   Exercise/Pledge.    To
the extent that this Section 6.4 is applicable, payment may be made by the delivery (on a form prescribed by the Company) of an
irrevocable direction to pledge Common Shares to a securities broker or lender approved by the Company, as security for a loan, and to deliver all or part of the loan proceeds to the Company in
payment of all or part of the Exercise Price and any withholding taxes. 

        6.5   Promissory
Note.    To the extent that this Section 6.5 is applicable, payment may be made with a full-recourse promissory note; provided
that the par value of the Common Shares shall be paid in cash. 

        6.6   Other
Forms of Payment.    To the extent that this Section 6.6 is applicable, payment may be made in any other form that is consistent with applicable
laws, regulations and rules. 

ARTICLE 7    STOCK APPRECIATION RIGHTS.  

        7.1   SAR
Agreement.    Each grant of an SAR under the Plan shall be evidenced by an SAR Agreement between the Optionee and the Company. Such SAR shall be subject
to all applicable terms of the Plan and may be subject to any other terms that are not inconsistent with the Plan. The provisions of the various SAR Agreements entered into under the Plan need not be
identical. SARs may be granted in consideration of a reduction in the Optionee's other compensation. 

        7.2   Number
of Shares.    Each SAR Agreement shall specify the number of Common Shares to which the SAR pertains and shall provide for the adjustment of such
number in accordance with Article 10. SARs granted to any Optionee in a single calendar year shall in no event pertain to more than 250,000 Common Shares, subject to adjustment in accordance
with Article 10. 

        7.3   Exercise
Price.    Each SAR Agreement shall specify the Exercise Price. An SAR Agreement may specify an Exercise Price that varies in accordance with a
predetermined formula while the SAR is outstanding. 

        7.4   Exercisability
and Term.    Each SAR Agreement shall specify the date when all or any installment of the SAR is to become exercisable. The SAR Agreement
shall also specify the term of the SAR. An SAR Agreement may provide for accelerated exercisability in the event of the Optionee's death, disability or retirement or other events and may provide for
expiration prior to the end of its term in the event of the termination of the Optionee's service. SARs may also be awarded in combination with Options, Restricted Shares or Stock Units, and such an
Award may provide that the SARs will not be exercisable unless the related Options, Restricted Shares or Stock Units are forfeited. An SAR may be included in an ISO only at the time of grant but may
be included in an NSO at the time of grant or thereafter. An SAR granted under the Plan may provide that it will be exercisable only in the event of a Change in Control. 

        7.5   Effect
of Change in Control.    The Committee may determine, at the time of granting an SAR or thereafter, that such SAR shall become fully exercisable as to
all Common Shares subject to such SAR in the event that a Change in Control occurs with respect to the Company. 

        7.6   Exercise
of SARs.    The exercise of an SAR shall be subject to the restrictions imposed by Rule 16b-3 (or its successor) under the
Exchange Act, if applicable. If, on the date when an SAR expires, the Exercise Price under such SAR is less than the Fair Market Value on such date but any portion of such SAR has not been exercised
or surrendered, then such SAR shall automatically be deemed to be exercised as of such date with respect to such portion. Upon exercise of an SAR, the Optionee (or any person having the right to
exercise the SAR after his or her death) shall receive from the Company (a) Common Shares, (b) cash or (c) a combination of Common Shares and cash, as the Committee shall
determine. The amount of cash and/or the Fair Market Value of Common Shares received upon exercise of SARs shall, in the aggregate, be equal to the amount by which the Fair Market Value (on the date
of surrender) of the Common Shares subject to the SARs exceeds the Exercise Price. 

        7.7   Modification
or Assumption of SARs.    Within the limitations of the Plan, the Committee may modify, extend or assume outstanding SARs or may accept the
cancellation of outstanding SARs (whether granted by the Company or by another issuer) in return for the grant of new SARs for the same or a different number of shares and at the same or a different
exercise price. The foregoing notwithstanding, no modification of an SAR shall, without the consent of the Optionee, alter or impair his or her rights or obligations under such SAR. 

ARTICLE 8    RESTRICTED SHARES AND STOCK UNITS.  

        8.1   Time,
Amount and Form of Awards.    Awards under the Plan may be granted in the form of Restricted Shares, in the form of Stock Units, or in any combination
of both. Restricted Shares or Stock Units may also be awarded in combination with NSOs or SARs, and such an Award may provide that the Restricted Shares or Stock Units will be forfeited in the event
that the related NSOs or SARs are exercised. 

        8.2   Payment
for Awards.    To the extent that an Award is granted in the form of newly issued Restricted Shares, the Award recipient, as a condition to the grant
of such Award, shall be required to pay the Company in cash an amount equal to the par value of such Restricted Shares. To the extent that an Award is granted in the form of Restricted Shares from the
Company's treasury or in the form of Stock Units, no cash consideration shall be required of the Award recipients. 

        8.3   Vesting
Conditions.    Each Award of Restricted Shares or Stock Units shall become vested, in full or in installments, upon satisfaction of the conditions
specified in the Stock Award Agreement. A Stock Award Agreement may provide for accelerated vesting in the event of the Participant's death, disability or retirement or other events. The Committee may
determine, at the time of making an Award or thereafter, that such Award shall become fully vested in the event that a Change in Control occurs with respect to the Company. 

        8.4   Form
and Time of Settlement of Stock Units.    Settlement of vested Stock Units may be made in the form of (a) cash, (b) Common Shares or
(c) any combination of both, as determined by the Committee. The actual number of Stock Units eligible for settlement may be larger or smaller than the number included in the original Award,
based on predetermined performance factors. Methods of converting Stock Units into cash may include (without limitation) a method based on the average Fair Market Value of Common Shares over a series
of trading days. Vested Stock Units may be settled in a lump sum or in installments. The distribution may occur or commence when all vesting conditions applicable to the Stock Units have been
satisfied or have lapsed, or it may be deferred to any later date. The amount of a deferred distribution may be increased by an interest factor or by dividend equivalents. Until an Award of Stock
Units is settled, the number of such Stock Units shall be subject to adjustment pursuant to Article 10. 

        8.5   Death
of Recipient.    Any Stock Units Award that becomes payable after the recipient's death shall be distributed to the recipient's beneficiary or
beneficiaries. Each recipient of a Stock Units Award under the Plan shall designate one or more beneficiaries for this purpose by filing the prescribed form with the Company. A beneficiary designation
may be changed by filing the prescribed form with the Company at any time before the Award recipient's death. If no beneficiary was 

designated
or if no designated beneficiary survives the Award recipient, then any Stock Units Award that becomes payable after the recipient's death shall be distributed to the recipient's estate. 

        8.6   Creditors'
Rights.    A holder of Stock Units shall have no rights other than those of a general creditor of the Company. Stock Units represent an unfunded
and unsecured obligation of the Company, subject to the terms and conditions of the applicable Stock Award Agreement. 

ARTICLE 9    VOTING AND DIVIDEND RIGHTS.  

        9.1   Restricted
Shares.    The holders of Restricted Shares awarded under the Plan shall have the same voting, dividend and other rights as the Company's other
stockholders. A Stock Award Agreement, however, may require that the holders of Restricted Shares invest any cash dividends received in additional Restricted Shares. Such additional Restricted Shares
shall be subject to the same conditions and restrictions as the Award with respect to which the dividends were paid. Such additional Restricted Shares shall not reduce the number of Common Shares
available under Article 3. 

        9.2   Stock
Units.    The holders of Stock Units shall have no voting rights. Prior to settlement or forfeiture, any Stock Unit awarded under the Plan may, at the
Committee's discretion, carry with it a right to dividend equivalents. Such right entitles the holder to be credited with an amount equal to all cash dividends paid on one Common Share while the Stock
Unit is outstanding. Dividend equivalents may be converted into additional Stock Units. Settlement of dividend equivalents may be made in the form of cash, in the form of Common Shares, or in a
combination of both. Prior to distribution, any dividend equivalents which are not paid shall be subject to the same conditions and restrictions as the Stock Units to which they attach. 

ARTICLE 10    PROTECTION AGAINST DILUTION.  

        10.1 Adjustments.    In
the event of a subdivision of the outstanding Common Shares, a declaration of a dividend payable in Common Shares, a declaration of a
dividend payable in a form other than Common Shares in an amount that has a material effect on the price of Common Shares, a combination or consolidation of the outstanding Common Shares (by
reclassification or otherwise) into a lesser number of Common Shares, a recapitalization, a spinoff or a similar occurrence, the Committee shall make such adjustments as it, in its sole discretion,
deems appropriate in one or more of (a) the number of Options, SARs, Restricted Shares and Stock Units available for future Awards under Article 3, (b) the limitations set forth
in Sections 5.2 and 7.2, (c) the number of NSOs to be granted to Outside Directors under Section 4.2, (d) the number of Stock Units included in any prior Award which has not yet
been settled, (e) the number of Common Shares covered by each outstanding Option and SAR or (f) the Exercise Price under each outstanding Option and SAR. Except as provided in this
Article 10, a Participant shall have no rights by reason of any issue by the Company of stock of any class or securities convertible into stock of any class, any subdivision or consolidation of
shares of stock of any class, the payment of any stock dividend or any other increase or decrease in the number of shares of stock of any class. 

        10.2 Reorganizations.    In
the event that the Company is a party to a merger or other reorganization, outstanding Options, SARs, Restricted Shares and Stock
Units shall be subject to the agreement of merger or reorganization. Such agreement may provide, without limitation, for the assumption of outstanding Awards by the surviving corporation or its
parent, for their continuation by the Company (if the Company is a surviving corporation), for accelerated vesting and accelerated expiration (provided the Company has previously had its initial
public offering), or for settlement in cash. 

ARTICLE 11    AWARDS UNDER OTHER PLANS.  

        The
Company may grant awards under other plans or programs. Such awards may be settled in the form of Common Shares issued under this Plan. Such Common Shares shall be treated for all
purposes under the Plan like Common Shares issued in settlement of Stock Units and shall, when issued, reduce the number of Common Shares available under Article 3. 

ARTICLE 12    PAYMENT OF DIRECTOR'S FEES IN SECURITIES.  

        12.1 Effective
Date.    No provision of this Article 12 shall be effective unless and until the Board has determined to implement such provision. 

        12.2 Elections
to Receive NSOs, Restricted Shares or Stock Units.    An Outside Director may elect to receive his or her annual retainer payments and meeting
fees from the Company in the form of cash, NSOs, Restricted Shares, Stock Units, or a combination thereof, as determined by the Board. Such NSOs, Restricted Shares and Stock Units shall be issued
under the Plan. An election under this Article 12 shall be filed with the Company on the prescribed form. 

        12.3 Number
and Terms of NSOs, Restricted Shares or Stock Units.    The number of NSOs, Restricted Shares or Stock Units to be granted to Outside Directors in
lieu of annual retainers and meeting fees that would otherwise be paid in cash shall be calculated in a manner determined by the Board. The terms of such NSOs, Restricted Shares or Stock Units shall
also be determined by the Board. 

ARTICLE 13    LIMITATION ON RIGHTS.  

        13.1 Retention
Rights.    Neither the Plan nor any Award granted under the Plan shall be deemed to give any individual a right to remain an employee, consultant
or director of the Company, a Parent or a Subsidiary. The Company and its Parents and Subsidiaries reserve the right to terminate the service of any employee, consultant or director at any time, with
or without cause, subject to applicable laws, the Company's certificate of incorporation and by-laws and a written employment agreement (if any). 

        13.2 Stockholders'
Rights.    A Participant shall have no dividend rights, voting rights or other rights as a stockholder with respect to any Common Shares
covered by his or her Award prior to the issuance of a stock certificate for such Common Shares. No adjustment shall be made for cash dividends or other rights for which the record date is prior to
the date when such certificate is issued, except as expressly provided in Articles 8, 9 and 10. 

        13.3 Regulatory
Requirements.    Any other provision of the Plan notwithstanding, the obligation of the Company to issue Common Shares under the Plan shall be
subject to all applicable laws, rules and regulations and such approval by any regulatory body as may be required. The Company reserves the right to restrict, in whole or in part, the delivery of
Common Shares pursuant to any Award prior to the satisfaction of all legal requirements relating to the issuance of such Common Shares, to their registration, qualification or listing or to an
exemption from registration, qualification or listing. 

ARTICLE 14    LIMITATION ON PAYMENTS.  

        The
following provisions in this Article 14 are effective for Awards granted on or after November 7, 2002. 

        14.1 Excise
Tax.    If any acceleration of the vesting of a Participant's Awards under this Plan ("Acceleration") would (i) constitute a "parachute
payment" within the meaning of Section 280G of the Internal Revenue Code of 1986, as amended (the "Code"), and (ii) but for this sentence, be subject to the excise tax imposed by
Section 4999 of the Code (the "Excise Tax"), then such Acceleration shall be reduced to the Reduced Amount. The "Reduced Amount" shall be whichever of the following which would provide the
largest after-tax benefit to the Participant: (i) the largest portion of the Acceleration that would result in no portion of the Acceleration being subject to the Excise Tax or
(ii) the largest portion, up to and including the total, of the Acceleration, whichever amount, after taking into account all applicable federal, state and local employment taxes, income taxes,
and the Excise Tax (all computed at the highest applicable marginal rate), results in Participant's receipt, on an after-tax basis, of the greater amount of the Acceleration
notwithstanding that all or some portion of the Payment may be subject to the Excise Tax. In the event that the Acceleration is to be reduced, such Acceleration shall be cancelled in the reverse order
of the date of grant of the Participant's Awards unless the Participant elects in writing a different order for cancellation. 

        The
accounting firm engaged by the Company for general audit purposes as of the day prior to the effective date of the transaction triggering the Acceleration ("Triggering Transaction")
shall perform the
foregoing calculations. If the accounting firm so engaged by the Company is serving as accountant or auditor for the individual, entity or group effecting the Triggering Transaction, the Company shall
appoint a nationally recognized accounting firm to make the determinations required hereunder. The Company shall bear all expenses with respect to the determinations by such accounting firm required
to be made hereunder. 

        14.2 Calculations.    The
accounting firm engaged to make the determinations hereunder shall provide its calculations, together with detailed supporting
documentation, to the Corporation and Participant within fifteen (15) calendar days after the date on which Participant's right to Acceleration arises (if requested at that time by the Company
or Participant) or at such other time as requested by the Company or Participant. If the accounting firm determines that no Excise Tax is payable with respect to an Acceleration, either before or
after the application of the Reduced Amount, it shall furnish the Company and Participant with an opinion reasonably acceptable to Participant that no Excise Tax will be imposed with respect to such
Acceleration. Any good faith determination of the accounting firm made hereunder shall be final, binding and conclusive upon the Company and Participant. 

        14.3 Related
Corporations.    For purposes of this Article 14, the term "Company" shall include affiliated corporations to the extent determined by the
accounting firm in accordance with section 280G(d)(5) of the Code. 

ARTICLE 15    WITHHOLDING TAXES.  

        15.1 General.    To
the extent required by applicable federal, state, local or foreign law, a Participant or his or her successor shall make arrangements
satisfactory to the Company for the satisfaction of any withholding tax obligations that arise in connection with the Plan. The Company shall not be required to issue any Common Shares or make any
cash payment under the Plan until such obligations are satisfied. 

        15.2 Share
Withholding.    The Committee may permit a Participant to satisfy all or part of his or her withholding or income tax obligations by having the
Company withhold all or a portion of any Common Shares that otherwise would be issued to him or her or by surrendering all or a portion of any Common Shares that he or she previously acquired. Such
Common Shares shall be valued at their Fair Market Value on the date when taxes otherwise would be withheld in cash. Any payment of taxes by assigning Common Shares to the Company may be subject to
restrictions, including any restrictions required by rules of the Securities and Exchange Commission. 

ARTICLE 16    ASSIGNMENT OR TRANSFER OF AWARDS.  

        16.1 General.    An
Award granted under the Plan shall not be anticipated, assigned, attached, garnished, optioned, transferred or made subject to any creditor's
process, whether voluntarily, involuntarily or by operation of law, except as approved by the Committee. Notwithstanding the foregoing, ISOs and, prior to the Company's initial public offering, NSOs
may not be transferable. However, this Article 16 shall not preclude a Participant from designating a beneficiary who will receive any outstanding Awards in the event of the Participant's
death, nor shall it preclude a transfer of Awards by will or by the laws of descent and distribution. 

        16.2 Trusts.    Neither
this Article 16 nor any other provision of the Plan shall preclude a Participant from transferring or assigning Restricted Shares
to (a) the trustee of a trust that is revocable by such Participant alone, both at the time of the transfer or assignment and at all times thereafter prior to such Participant's death, or
(b) the trustee of any other trust to the extent approved in advance by the Committee in writing. A transfer or assignment of Restricted Shares from such trustee to any person other than such
Participant shall be permitted only to the extent approved in advance by the Committee in writing, and Restricted Shares held by such trustee shall be subject to all 

of
the conditions and restrictions set forth in the Plan and in the applicable Stock Award Agreement, as if such trustee were a party to such Agreement. 

ARTICLE 17    FUTURE OF THE PLAN.  

        17.1 Term
of the Plan.    The Plan, as set forth herein, was adopted on December 5, 1996, and became effective December 1, 1996, except that
Articles 7, 8 and 9 shall not be effective prior to the date of the Company's initial public offering. The Plan shall remain in effect until it is terminated under Section 17.2, except that no
ISOs shall be granted after November 30, 2006. 

        17.2 Amendment
or Termination.    The Board may, at any time and for any reason, amend or terminate the Plan. An amendment of the Plan shall be subject to the
approval of the Company's stockholders only to the extent required by applicable laws, regulations or rules. No Awards shall be granted under the Plan after the termination thereof. The termination of
the Plan, or any amendment thereof, shall not affect any Award previously granted under the Plan. 

ARTICLE 18    DEFINITIONS.  

        18.1 "Award"
means any award of an Option, an SAR, a Restricted Share or a Stock Unit under the Plan. 

        18.2 "Board"
means the Company's Board of Directors, as constituted from time to time. 

        18.3 "Change
in Control" shall mean the occurrence of any of the following events: 

        (a)   The
consummation of a merger or consolidation of the Company with or into another entity or any other corporate reorganization, if more than 50% of the combined voting
power of the continuing or surviving entity's securities outstanding immediately after such merger, consolidation or other reorganization is owned by persons who were not stockholders of the Company
immediately prior to such merger, consolidation or other reorganization; 

        (b)   A
change in the composition of the Board, as a result of which fewer than one-half of the incumbent directors are directors who either: 

        (A)  Had
been directors of the Company 24 months prior to such change; or 

        (B)  Were
elected, or nominated for election, to the Board with the affirmative votes of at least a majority of the directors who had been directors of the Company
24 months prior to such change and who were still in office at the time of the election or nomination; or 

        (c)   Any
"person" (as such term is used in sections 13(d) and 14(d) of the Exchange Act) by the acquisition or aggregation of securities is or becomes the beneficial owner,
directly or indirectly, of securities of the Company representing 50% or more of the combined voting power of the Company's then outstanding securities ordinarily (and apart from rights accruing under
special circumstances) having the right to vote at elections of directors (the "Base Capital Stock"); except that any change in the relative beneficial ownership of the Company's securities by any
person resulting solely from a reduction in the aggregate number of outstanding shares of Base Capital Stock, and any decrease thereafter in such person's ownership of securities, shall be disregarded
until such person increases in any manner, directly or indirectly, such person's beneficial ownership of any securities of the Company. 

        The
term "Change in Control" shall not include the Company's initial public offering or a transaction, the sole purpose of which is to change the state of the Company's incorporation. 

        18.4 "Code"
means the Internal Revenue Code of 1986, as amended. 

        18.5 "Committee"
means a committee of the Board, as described in Article 2. 

        18.6 "Common
Share" means one share of the common stock of the Company. 

        18.7 "Company"
means Biosite Incorporated, a Delaware corporation. 

        18.8 "Exchange
Act" means the Securities Exchange Act of 1934, as amended. 

        18.9 "Exercise
Price," in the case of an Option, means the amount for which one Common Share may be purchased upon exercise of such Option, as specified in the applicable
Stock Option Agreement. "Exercise Price," in the case of an SAR, means an amount, as specified in the applicable SAR Agreement, which is subtracted from the Fair Market Value of one Common Share in
determining the amount payable upon exercise of such SAR. 

        18.10 "Fair
Market Value" means the market price of Common Shares, determined by the Committee as follows: 

        (a)   If
the Common Shares were traded over-the-counter on the date in question but was not traded on the Nasdaq Stock Market or the Nasdaq National
Market, then the Fair Market Value shall be equal to the mean between the last reported representative bid and asked prices quoted for such date by the principal automated inter-dealer quotation
system on which the Common Shares are quoted or, if the Common Shares are not quoted on any such system, by the "Pink Sheets" published by the National Quotation Bureau, Inc.; 

        (b)   If
the Common Shares were traded over-the-counter on the date in question and were traded on the Nasdaq Stock Market or the Nasdaq National
Market, then the Fair Market Value shall be equal to the last-transaction price quoted for such date by the Nasdaq Stock Market or the Nasdaq National Market; 

        (c)   If
the Common Shares were traded on a stock exchange on the date in question, then the Fair Market Value shall be equal to the closing price reported by the applicable
composite transactions report for such date; and 

        (d)   If
none of the foregoing provisions is applicable, then the Fair Market Value shall be determined by the Committee in good faith on such basis as it deems appropriate. 

        Whenever
possible, the determination of Fair Market Value by the Committee shall be based on the prices reported in the Western Edition of The Wall Street Journal. Such determination
shall be conclusive and binding on all persons. 

        18.11 "ISO"
means an incentive stock option described in section 422(b) of the Code. 

        18.12 "Key
Employee" means (a) a common-law employee of the Company, a Parent or a Subsidiary, (b) an Outside Director and (c) a consultant
or adviser who provides services to the Company, a Parent or a Subsidiary as an independent contractor. Service as an Outside Director or as an independent contractor shall be considered employment
for all purposes of the Plan, except as provided in Sections 4.2 and 4.3. 

        18.13 "NSO"
means a stock option not described in sections 422 or 423 of the Code. 

        18.14 "Option"
means an ISO or NSO granted under the Plan and entitling the holder to purchase one Common Share. 

        18.15 "Optionee"
means an individual or estate who holds an Option or SAR. 

        18.16 "Outside
Director" shall mean a member of the Board who is not a common-law employee of the Company, a Parent or a Subsidiary. 

        18.17 "Parent"
means any corporation (other than the Company) in an unbroken chain of corporations ending with the Company, if each of the corporations other than the
Company owns stock possessing 50% or more of the total combined voting power of all classes of stock in one of the other corporations in such chain. A corporation that attains the status of a Parent
on a date after the adoption of the Plan shall be considered a Parent commencing as of such date. 

        18.18 "Participant"
means an individual or estate who holds an Award. 

        18.19 "Plan"
means this 1996 Stock Incentive Plan of Biosite Incorporated, as amended from time to time. 

        18.20 "Restricted
Share" means a Common Share awarded under the Plan. 

        18.21 "SAR"
means a stock appreciation right granted under the Plan. 

        18.22 "SAR
Agreement" means the agreement between the Company and an Optionee which contains the terms, conditions and restrictions pertaining to his or her SAR. 

        18.23 "Stock
Award Agreement" means the agreement between the Company and the recipient of a Restricted Share or Stock Unit which contains the terms, conditions and
restrictions pertaining to such Restricted Share or Stock Unit. 

        18.24 "Stock
Option Agreement" means the agreement between the Company and an Optionee which contains the terms, conditions and restrictions pertaining to his or her Option. 

        18.25 "Stock
Unit" means a bookkeeping entry representing the equivalent of one Common Share, as awarded under the Plan. 

        18.26 "Subsidiary"
means any corporation (other than the Company) in an unbroken chain of corporations beginning with the Company, if each of the corporations other than the
last corporation in the unbroken chain owns stock possessing 50% or more of the total combined voting power of all classes of stock in one of the other corporations in such chain. A corporation that
attains the status of a Subsidiary on a date after the adoption of the Plan shall be considered a Subsidiary commencing as of such date. 

ARTICLE 19    EXECUTION.  

        To
record the adoption of the Plan by the Board, the Company has caused its duly authorized officer to affix the corporate name and seal hereto. 

	 	 	BIOSITE INCORPORATED
	

 	
 	

By	

 
	 	 	 	

 
 

ADDENDUM TO THE
  AMENDED AND RESTATED 1996 STOCK
  INCENTIVE PLAN OF BIOSITE INCORPORATED
  
    (For Grants to Recipients Based in France)    
    

        The Amended and Restated 1996 Stock Incentive Plan of Biosite Incorporated (the "Plan") is hereby amended by Biosite Incorporated, a Delaware corporation (the
"Company"), to be effective as of the            
day of December, 2002, as provided in this Addendum to the Biosite Incorporated Stock Option Plan (this "Addendum"). This Addendum shall apply solely to grants of stock options under the Plan
("Options") to recipients who are based in France. 

Options
granted before May 16, 2001 under the Plan to eligible persons for the time being based in France (the "employees") will be granted under the terms of this Addendum as follows: 

        (1)   Notwithstanding
any other provision of the Plan, Options granted to any eligible person who is an "Administrateur"(director), member of the "conseil de surveillance", or
consultant who does not have a work contract with the Company, will not be deemed to have been granted pursuant to this Addendum. 

        (2)   Notwithstanding
any other provision of the Plan, any Options granted to any eligible employee who is holding shares representing 10% or more of the Company's capital
will not be deemed to have been granted pursuant to this Addendum. 

        (3)   Notwithstanding
any other provision of the Plan, any option granted which strike price at the time of the grant of the option is less than 80% of the average of the
market value of a share on the twenty (20) daily sessions preceding the related date of grant or 80% of the average purchase price of these shares by the Company will not be deemed to have been
granted under this Addendum. 

        (4)   Notwithstanding
any other provision of the Plan, any option granted during the twenty (20) trading days after the payment of a dividend or after an increase of
capital reserved to the shareholders will not be deemed to have been granted under this Addendum. 

        (5)   Notwithstanding
any other provision of the Plan, the strike price is intangible and shall be adjusted only upon the occurrence of the events specified under
July 24, 1966 corporate law (section L. 225-181) in accordance with French law. 

        (6)   Notwithstanding
any other provision of the Plan, the Board of Directors of the Company cannot impose to the employees to hold the shares for more than three
(3) years after the exercise date. 

        (7)   Notwithstanding
any other provision of the Plan, Options cannot be transferred or otherwise disposed of. 

        (8)   Notwithstanding
any other provision of the Plan, in the case of the death of an optionholder, his or her heirs can exercise the stock options granted to the deceased
optionholder within a six month period from the date of the optionholder's death. 

        For
options granted on or after May 16, 2001 under the Plan to employees based in France the above Articles (1) through (8) will apply and an Article 9 should
be included and read as follows: 

        (9)   Notwithstanding
any other provision of the Plan, Options granted: 

	(a)
	during
the period corresponding to ten (10) stock exchange sessions preceding and following the date on which the consolidated accounts, or failing of this, the annual
financial statements, are made public; or

	(b)
	during
the period starting at the date at which the corporate management of the Company is aware of an unpublished price-sensitive information and ending ten (10) trading days
after the publication of this information; 

shall
not be deemed to have been granted under this Addendum. 

QuickLinks

BIOSITE INCORPORATED AMENDED AND RESTATED STOCK INCENTIVE PLAN Effective June 18, 2003

ADDENDUM TO THE AMENDED AND RESTATED 1996 STOCK INCENTIVE PLAN OF BIOSITE INCORPORATED (For Grants to Recipients Based in France)

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