Document:

EX-10.12

 Exhibit 10.12 
 [*] = Certain confidential information contained in this document, marked by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended.

 PUBLIC HEALTH SERVICE 
 COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT 
 FOR INTRAMURAL-PHS CLINICAL RESEARCH 
 This Agreement is based on the model Cooperative Research and
Development Agreement (“CRADA”) adopted by the U.S. Public Health Service (“PHS”) Technology Transfer Policy Board for use by components of the National Institutes of Health (“NIH”), the Centers for Disease Control and
Prevention (“CDC”), and the Food and Drug Administration (“FDA”), which are agencies of the PHS within the Department of Health and Human Services (“HHS”). 
 This Cover Page identifies the Parties to this CRADA: 
 The U.S. Department of
Health and Human Services, as represented by 
 National Cancer Institute 

an Institute, Center, or Division (hereinafter referred to as the “ICD”) of the 

NIH 
 and

 GlobeImmune, Inc., 
 hereinafter referred to as the “Collaborator”, 
 having offices at 1450
Infinite Drive., Louisville, CO 80027, 
 created and operating under the laws of the State of Delaware. 

 

					
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 [*] = Certain confidential information contained in this document, marked
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 COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT 

FOR INTRAMURAL-PHS CLINICAL RESEARCH 

Article 1 Introduction 
 This CRADA
between ICD and Collaborator will be effective when signed by the Parties, which are identified on both the Cover Page and the Signature Page (page 21). The official contacts for the Parties are identified on the Contacts Information Page (page 22).
Publicly available information regarding this CRADA appears on the Summary Page (page 23). The research and development activities that will be undertaken by ICD and Collaborator in the course of this CRADA are detailed in the Research Plan,
attached as Appendix A. The staffing, funding, and materials contributions of the Parties are set forth in Appendix B. Any changes to the model CRADA are set forth in Appendix C. 
 Article 2 Definitions 
 The terms listed in this Article will carry the meanings indicated
throughout the CRADA. To the extent a definition of a term as provided in this Article is inconsistent with a corresponding definition in the applicable sections of either the United States Code (U.S.C.) or the Code of Federal Regulations (C.F.R.),
the definition in the U.S.C. or C.F.R. will control. 
 “Adverse Drug Experience” or “ADE”
means an Adverse Event associated with the use of the Test Article, that is, an event where there is a reasonable possibility that the Test Article may have caused the event (a relationship between the Test Article and the event cannot be ruled
out), in accordance with the definitions of 21 C.F.R. Part 305, 310, or 312, or other applicable regulations. 

“Adverse Event” or “AE” means any untoward medical occurrence in a Human Subject administered Test
Article. An AE does not necessarily have a causal relationship with the Test Article, that is, it can be any unfavorable and unintended sign (including an abnormal laboratory finding), symptom, or disease temporally associated with the use of the
Test Article, whether or not it is related to it. See FDA Good Clinical Practice Guideline (from International Conference on Harmonisation (ICH) E6: “Good Clinical Practice: Consolidated Guidance, 62 Federal Register 25, 691 (1997)).

 “Affiliate” means any corporation or other business entity controlled by, controlling, or under common
control with Collaborator at any time during the term of the CRADA. For this purpose, “control” means direct or indirect beneficial ownership of at least fifty percent (50%) of the voting stock or at least fifty percent
(50%) interest in the income of the corporation or other business entity. 
 “Annual Report” means the
report of progress of an IND-associated investigation that ICD, as the IND Sponsor, must submit to the FDA within sixty (60) days of the anniversary of the effective date of the IND (pursuant to 21
C.F.R.§ 312.33). 

  

					
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 “Background Invention” means an Invention conceived and first actually
reduced to practice before the Effective Date. 
 “Clinical Investigator” means, in accordance with 21 C.F.R.
§ 312.3, an individual who actually conducts a clinical investigation, that is, who directs the administration or dispensation of Test Article to a subject, and who assumes responsibility for studying Human Subjects, for recording and ensuring
the integrity of research data, and for protecting the welfare and safety of Human Subjects. 
 “Collaborator
Materials” means all tangible materials not first produced in the performance of this CRADA that are owned or controlled by Collaborator and used in the performance of the Research Plan. The term “Collaborator Materials” does not
include “Test Article” (defined below). 
 “Confidential Information” means confidential scientific,
business, financial information, or Identifiable Private Information provided that the information does not include: 
  

	 	(a)	information that is publicly known or that is available from public sources; 

 

	 	(b)	information that has been made available by its owner to others without a confidentiality obligation; 

 

	 	(c)	information that is already known by the receiving Party, or information that is independently created or compiled by the receiving Party without reference to or use of
the provided information; or 

  

	 	(d)	information that relates to potential hazards or cautionary warnings associated with the production, handling, or use of the subject matter of the Research Plan.

 “Cooperative Research and Development Agreement” or “CRADA” means this
Agreement, entered into pursuant to the Federal Technology Transfer Act of 1986, as amended (15 U.S.C. §§ 3710a et seq.), and Executive Order 12591 of April 10, 1987. 

“CRADA Data” means all recorded information first produced in the performance of the Research Plan. 

“CRADA Materials” means all tangible materials first produced in the performance of the Research Plan other than CRADA
Data. 
 “CRADA Principal Investigator(s)” or “CRADA PI(s)” means the person(s) designated by
the Parties who will be responsible for the scientific and technical conduct of the Research Plan. The CRADA PI may also be a Clinical Investigator. 
 “CRADA Subject Invention” means any Invention of either or both Parties, conceived or first actually reduced to practice in the performance of the Research Plan. 

  

					
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 “Drug Master File” or “DMF” is described in 21 C.F.R.
Part 314.420. A DMF is a submission to the FDA that may be used to provide confidential detailed information about facilities, processes, or articles used in the manufacturing, processing, packaging, and storing of one or more human drugs.

 “Effective Date” means the date of the last signature of the Parties executing this Agreement. 

“Government” means the Government of the United States of America. 

“Human Subject” means, in accordance with the definition in 45 C.F.R. § 46.102(f), a living individual about whom
an investigator conducting research obtains: 
  

	 	(a)	data through intervention or interaction with the individual; or 

  

	 	(b)	Identifiable Private Information. 

 “ICD Materials” means all tangible materials not first produced in the performance of this CRADA that are owned or controlled by ICD and used in the performance of the Research Plan.

 “IND” means an “Investigational New Drug Application”, filed in accordance with 21 C.F.R.
Part 312 under which clinical investigation of an experimental drug or biologic (Test Article) is performed in Human Subjects in the United States or intended to support a United States licensing action. 

“Identifiable Private Information” or “IPI” about a Human Subject means private information from which
the identity of the subject is or may readily be ascertained. Regulations defining and governing this information include 45 C.F.R. Part 46 and 21 C.F.R. Part 50. 
 “Institutional Review Board” or “IRB” means, in accordance with 45 C.F.R. Part 46, 21 C.F.R. part 56, and other applicable regulations, an independent body comprising
medical, scientific, and nonscientific members, whose responsibility is to ensure the protection of the rights, safety, and well-being of the Human Subjects involved in a study. 

“Invention” means any invention or discovery that is or may be patentable or otherwise protected under Title 35 of the
United States Code, or any novel variety of plant which is or may be protectable under the Plant Variety Protection Act, 7 U.S.C. §§ 2321 et seq. 
 “Investigator’s Brochure” means, in accordance with the definition in 21 C.F.R. § 312.23(a)(5), a document containing information about the Test Article, including animal
screening, preclinical toxicology, and detailed pharmaceutical data, including a description of possible risks and side effects to be anticipated on the basis of prior experience with the drug or related drugs, and precautions, such as additional
monitoring, to be taken as part of the investigational use of the drug. 

  

					
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 “Patent Application” means an application for patent protection for a
CRADA Subject Invention with the United States Patent and Trademark Office (“U.S.P.T.O.”) or the corresponding patent-issuing authority of another nation. 
 “Patent” means any issued United States patent, any international counterpart(s), and any corresponding grant(s) by a non-U.S. government in place
of a patent. 
 “Placebo” means an inactive substance identical in appearance to the material being tested that
is used to distinguish between drug action and suggestive effect of the material under study. 
 “Protocol”
means the formal, detailed description of a study to be performed as provided for in the Research Plan. It describes the objective(s), design, methodology, statistical considerations, and organization of a trial. For the purposes of this CRADA, the
term, Protocol, for clinical research involving Human Subjects, includes any and all associated documents, including informed consent forms, to be provided to Human Subjects and potential participants in the study. 

“Raw Data” means the primary quantitative and empirical data first collected from experiments and clinical trials
conducted within the scope of this CRADA. 
 “Research Plan” means the statement in Appendix A of the
respective research and development commitments of the Parties, The Research Plan should describe the provisions for sponsoring the IND, clinical and safety monitoring, and data management. 

“Sponsor” means, in accordance with the definition in 21 C.F.R. § 312.3, an organization or individual who assumes
legal responsibility for supervising or overseeing clinical trials with Test Articles, and is sometimes referred to as the IND holder. 
 “Steering Committee” means the research and development team whose composition and responsibilities with regard to the research performed under this CRADA are described in Appendix A.

 “Summary Data” means any extract or summary of the Raw Data, generated either by, or on behalf of, ICD or
by, or on behalf of, Collaborator. Summary Data may include extracts or summaries that incorporate IPI. 
 “Test
Article” means, in accordance with 21 C.F.R. 50.3 (j), any drug (including a biological product), medical device, food additive, color additive, electronic product, or any other article subject to regulation under the Federal Food, Drug,
and Cosmetic Act that is intended for administration to humans or animals, including a drug or biologic as identified in the Research Plan and Appendix B, that is used within the scope of the Research Plan. The Test Article may also be referred to
as Investigational Agent, Study Material, or Study Product. 

  

					
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 Article 3 Cooperative Research and Development 

 

	3.1	Performance of Research and Development. The research and development activities to be carried out under this CRADA will be performed solely by the Parties
identified on the Cover Page, unless specifically stated elsewhere in the Agreement. The CRADA PIs will be responsible for coordinating the scientific and technical conduct of this project on behalf of their employers. Any Collaborator employees who
will work at ICD facilities will be required to sign a Guest Researcher or Special Volunteer Agreement appropriately modified in view of the terms of this CRADA. 

 

	3.2	Research Plan. The Parties recognize that the Research Plan describes the collaborative research and development activities they will undertake and that interim
research goals set forth in the Research Plan are good faith guidelines. Should events occur that require modification of these goals, then by mutual agreement the Parties can modify them through an amendment, according to Paragraph 13.6.

  

	3.3	Use and Disposition of Collaborator Materials and ICD Materials. The Parties agree to use Collaborator Materials and ICD Materials only in accordance with the
Research Plan and Protocol(s), not to transfer these materials to third parties except in accordance with the Research Plan and Protocol(s) or as approved by the owning or providing Party, and, upon expiration or termination of the CRADA, to dispose
of these materials as directed by the owning or providing Party. 

  

	3.4	Third-Party Rights in Collaborator’s CRADA Subject Inventions. If Collaborator has received (or will receive) support of any kind from a third party in
exchange for rights in any of Collaborator’s CRADA Subject Inventions, Collaborator agrees to ensure that its obligations to the third party are both consistent with Articles 6 through 8 and subordinate to Article 7 of this CRADA.

  

	3.5	Disclosures to ICD. Prior to execution of this CRADA, Collaborator agrees to disclose to ICD all instances in which outstanding royalties are due under a PHS
license agreement and in which Collaborator had a PHS license terminated in accordance with 37 C.F.R. § 404.10. These disclosures will be treated as Confidential Information upon request by Collaborator in accordance with the definition in
Article 2 and Paragraphs 8.3 and 8.4. 

  

	3.6	Clinical Investigator Responsibilities. The Clinical Investigator will be required to submit, or to arrange for submission of, each Protocol associated with this
CRADA to the IRB. In addition to the Protocol all associated documents, including informational documents and advertisements, must be reviewed and approved by the IRB before 

  

					
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 starting the research. The research will be done in strict accordance with the
Protocol(s) and no substantive changes in a finalized Protocol will be made unless mutually agreed upon, in writing, by the Parties. Research will not commence (or will continue unchanged, if already in progress) until each substantive change to a
Protocol, including those required by either the FDA or the IRB, has been integrated in a way acceptable to the Parties, submitted to the FDA (if applicable) and approved by the IRB. 

 

	3.7	Investigational Applications. 

  

	 	3.7.1 	If an IND is required, ICD will be the IND Sponsor and will submit an IND. All Clinical Investigators must have completed registration documents on file (1572 forms).

  

	 	3.7.2 	When ICD files the IND, Collaborator agrees to provide ICD background data and information necessary to support the IND. Collaborator further agrees to provide a letter
of cross-reference to all pertinent regulatory filings sponsored by Collaborator. Collaborator’s employees will be reasonably available to respond to inquiries from the FDA regarding information and data contained in the Collaborator’s
IND, DMF, other filings, or other information and data provided to ICD by the Collaborator pursuant to this Article 3. 

  

	 	3.7.3 	If Collaborator supplies Confidential Information to ICD in support of an IND filed by ICD, this information will be protected in accordance with the corresponding
confidentiality provisions of Article 8. 

  

	 	3.7.4 	Collaborator may sponsor its own clinical trials and hold its own IND for studies performed outside the scope of this CRADA. These studies, however, should not
adversely affect the ability to accomplish the goal of the Research Plan, for example, by competing for the same study population. All data from those clinical trials are proprietary to Collaborator for purposes of this CRADA.

  

	3.8	Test Article Information and Supply. Collaborator agrees to provide ICD without charge and on a schedule that will ensure adequate and timely performance of the
research, a sufficient quantity of formulated and acceptably labeled, clinical-grade Test Article (and, as required by the Protocol(s), Placebo) to complete the clinical trial(s) agreed to and approved under this CRADA. Collaborator will provide a
Certificate of Analysis to ICD for each lot of the Test Article provided. 

  

	3.9	Test Article Delivery and Usage. Collaborator will ship the Test Article and, if required, Placebo to ICD in containers marked in accordance with 21 C.F.R.
§ 312.6. ICD agrees that the Clinical Investigators will keep appropriate records and take reasonable steps to ensure that the Test Article is used in accordance with the Protocol(s) and applicable FDA regulations. In addition, ICD agrees that
the Test Article (and all Confidential Information supplied by Collaborator relating to the Test Article) will be used solely for 

  

					
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 the conduct of the CRADA research and development activities. Furthermore, ICD agrees
that no analysis or modification of the Test Article will be performed without Collaborator’s prior written consent. At the completion of the Research Plan, any unused quantity of Test Article will be returned to Collaborator or disposed as
directed by Collaborator. Pharmacy contacts at ICD will be determined by ICD and communicated to Collaborator. 
  

	3.10	Monitoring. Subject to the restrictions in Article 8 concerning IPI, and with reasonable advance notice and at reasonable times, ICD will permit Collaborator or
its designee(s) to monitor the conduct of the research, as well as to audit source documents containing Raw Data, to the extent necessary to verify compliance with FDA Good Clinical Practice (International Conference on Harmonisation (ICH) E6:
“Good Clinical Practice: Consolidated Guidance; 62 Federal Register 25, 691 (1997)) and the Protocol(s). 

  

	3.11	FDA Meetings/Communications. All meetings with the FDA concerning any clinical trial within the scope of the Research Plan will be discussed by Collaborator and
ICD in advance. Each Party reserves the right to take part in setting the agenda for, to attend, and to participate in these meetings. ICD will provide Collaborator with copies of FDA meeting minutes, all transmittal letters for IND submissions, IND
safety reports, formal questions and responses that have been submitted to the FDA, Annual Reports, and official FDA correspondence, pertaining either to the INDs under this CRADA or to the Clinical Investigators on Protocols performed in accordance
with the Research Plan, except to the extent that those documents contain the proprietary information of a third party or dissemination is prohibited by law. 

 Article 4 Reports 
  

	4.1	Interim Research and Development Reports. The CRADA PIs should exchange information regularly, in writing. This exchange may be accomplished through meeting
minutes, detailed correspondence, circulation of draft manuscripts, Steering Committee reports, copies of Annual Reports and any other reports updating the progress of the CRADA research. However, the Parties must exchange updated
Investigator’s Brochure, formulation and preclinical data, and toxicology findings, as they become available. 

  

	4.2	Final Research and Development Reports. The Parties will exchange final reports of their results within six (6) months after the expiration or termination
of this CRADA. These reports will set forth the technical progress made; any publications arising from the research; and the existence of invention disclosures of potential CRADA Subject Inventions and/or any corresponding Patent Applications.

  

	4.3	Fiscal Reports. If Collaborator has agreed to provide funding to ICD under this CRADA and upon the request of Collaborator, then concurrent with the exchange of
final research and development reports according to Paragraph 4.2, ICD will submit to Collaborator a statement of all costs incurred by ICD for the CRADA. If the CRADA has been 

  

					
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 terminated, ICD will specify any costs incurred before the date of termination for which
ICD has not received funds from Collaborator, as well as for all reasonable termination costs including the cost of returning Collaborator property or removal of abandoned Collaborator property, for which Collaborator will be responsible.

  

	4.4	Safety Reports. In accordance with FDA requirements ICD, as the IND Sponsor, will establish and maintain records and submit safety reports to the FDA, as
required by 21 C.F.R. § 312.32 and 21 C.F.R. 812.150(b)(1), or other applicable regulations. In the conduct of research under this CRADA, the Parties will comply with specific ICD guidelines and policies for reporting ADEs and AEs, as well as
procedures specified in the Protocol(s). ICD must provide Collaborator with copies of all Safety Reports concurrently with their submission to the FDA, and with any other information affecting the safety of Human Subjects in research conducted under
this CRADA. 

  

	4.5	Annual Reports. ICD will provide Collaborator a copy of the Annual Report concurrently with the submission of the Annual Report to the FDA. Annual Reports will
be kept confidential in accordance with Article 8. 

 Article 5 Staffing, Financial, and Materials Obligations 

 

	5.1	ICD and Collaborator Contributions. The contributions of any staff, funds, materials, and equipment by the Parties are set forth in Appendix B. The Federal
Technology Transfer Act of 1986, 15 U.S.C. § 3710a(d)(1) prohibits ICD from providing funds to Collaborator for any research and development activities under this CRADA. 

 

	5.2	ICD Staffing. No ICD employees will devote 100% of their effort or time to the research and development activities under this CRADA. LCD will not use funds
provided by Collaborator under this CRADA for ICD personnel to pay the salary of any permanent ICD employee. Although personnel hired by ICD using CRADA funds will focus principally on CRADA research and development activities, Collaborator
acknowledges that these personnel may nonetheless make contributions to other research and development activities, and the activities will be outside the scope of this CRADA. 

 

	5.3	Collaborator Funding. Collaborator acknowledges that Government funds received by Collaborator from an agency of the Department of Health and Human Services may
not be used to fund ICD under this CRADA. If Collaborator has agreed to provide funds to ICD then the payment schedule appears in Appendix B and Collaborator will make payments according to that schedule. If Collaborator fails to make any scheduled
payment, ICD will not be obligated to perform any of the research and development activities specified herein or to take any other action required by this CRADA until the funds are received. ICD will use these funds exclusively for the purposes of
this CRADA. Each Party will maintain separate and distinct current accounts, records, and other evidence supporting its financial obligations under this CRADA and, upon written request, will provide the other Party a Fiscal Report according to
Paragraph 4.3, which delineates all payments made and all obligated expenses, along with the Final Research Report described in Paragraph 4.2. 

  

					
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	5.4	Capital Equipment. Collaborator’s commitment, if any, to provide ICD with capital equipment to enable the research and development activities under the
Research Plan appears in Appendix B. If Collaborator transfers to ICD the capital equipment or provides funds for ICD to purchase it, then ICD will own the equipment. If Collaborator loans capital equipment to ICD for use during the CRADA,
Collaborator will be responsible for paying all costs and fees associated with the transport, installation, maintenance, repair, removal, or disposal of the equipment, and ICD will not be liable for any damage to the equipment.

 Article 6 Intellectual Property 
  

	6.1	Ownership of CRADA Subject Inventions, CRADA Data, and CRADA Materials. Subject to the Government license described in Paragraph 7.5, the sharing requirements of
Paragraph 8.1 and the regulatory filing requirements of Paragraph 8.2, the producing Party will retain sole ownership of and title to all CRADA Subject Inventions, all copies of CRADA Data, and all CRADA Materials produced solely by its employee(s).
The Parties will own jointly all CRADA Subject Inventions invented jointly and all CRADA Materials developed jointly. 

  

	6.2	Reporting. The Parties will promptly report to each other in writing each CRADA Subject Invention reported by their respective personnel, and any Patent
Applications filed thereon, resulting from the research and development activities conducted under this CRADA. Each Party will report all CRADA Subject Inventions to the other Party in sufficient detail to determine inventor ship, which will be
determined in accordance with U.S. patent law. These reports will be treated as Confidential Information in accordance with Article 8. Formal reports will be made by and to the Patenting and Licensing Offices identified on the Contacts Information
Page herein. 

  

	6.3	Filing of Patent Applications. Each Party will make timely decisions regarding the filing of Patent Applications on the CRADA Subject Inventions made solely by
its employee(s), and will notify the other Party in advance of filing. Collaborator will have the first opportunity to file a Patent Application on joint CRADA Subject Inventions and will notify PHS of its decision within sixty (60) days of an
Invention being reported or at least thirty (30) days before any patent filing deadline, whichever occurs sooner. If Collaborator fails to notify PHS of its decision within that time period or notifies PHS of its decision not to file a Patent
Application, then PHS has the right to file a Patent Application on the joint CRADA Subject Invention. Neither Party will be obligated to file a Patent Application. Collaborator will place the following statement in any Patent Application it files
on a CRADA Subject. Invention: “This invention was created in the performance of a Cooperative Research and Development Agreement with the [INSERT into Agency’s model as appropriate: National Institutes of Health, Food and Drug

  

					
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 Administration, Centers for Disease Control and Prevention], an Agency of the
Department of Health and Human Services. The Government of the United States has certain rights in this invention.” If either Party files a Patent Application on a joint CRADA Subject Invention, then the filing Party will include a statement
within the Patent Application that clearly identifies the Parties and states that the joint CRADA Subject Invention was made under this CRADA. 
  

	6.4	Patent Expenses. Unless agreed otherwise, the Party filing a Patent Application will pay all preparation and filing expenses, prosecution fees, issuance fees,
post issuance fees, patent maintenance fees, annuities, interference expenses, and attorneys’ fees for that Patent Application and any resulting Patent(s). If a license to any CRADA Subject Invention is granted to Collaborator, then
Collaborator will be responsible for all expenses and fees, past and future, in connection with the preparation, filing, prosecution, and maintenance of any Patent Applications and Patents claiming exclusively licensed CRADA Subject Inventions and
will be responsible for a pro-rated share, divided equally among all licensees, of those expenses and fees for non-exclusively licensed CRADA Subject Inventions.
Collaborator may waive its exclusive option rights at any time, and incur no subsequent financial obligation for those Patent Application(s) or Patent(s). 

 

	6.5	Prosecution of Patent Applications. The Party filing a Patent Application will provide the non-filing Party with a copy
of any official communication relating to prosecution of the Patent Application within thirty (30) days of transmission of the communication. Each Party will also provide the other Party with the power to inspect and make copies of all
documents retained in the applicable Patent Application or Patent file. The Parties agree to consult with each other regarding the prosecution of Patent Applications directed to joint CRADA Subject Inventions. If Collaborator elects to file and
prosecute Patent Applications on joint CRADA Subject Inventions, then Collaborator agrees to use the U.S.P.T.O. Customer Number Practice and/or grant PHS a power(s) of attorney (or equivalent) necessary to assure PHS access to its intellectual
property rights in these Patent Applications. PHS and Collaborator will cooperate with each other to obtain necessary signatures on Patent Applications, assignments, or other documents. 

Article 7 Licensing 
  

	7.1	Background Inventions. Other than as specifically stated in this Article 7, nothing in this CRADA will be construed to grant any rights in one Party’s
Background Invention(s) to the other Party, except to the extent necessary for the Parties to conduct the research and development activities described in the Research Plan. 

 

	7.2	Collaborator’s License Option to CRADA Subject Inventions. With respect to Government rights to any CRADA Subject Invention made solely by an ICD
employee(s) or made jointly by an ICD employee(s) and a Collaborator employee(s) for which a Patent Application was filed, PHS hereby grants to Collaborator an exclusive option to elect an exclusive or nonexclusive commercialization license. The
license will be 

  

					
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 substantially in the form of the appropriate model PHS license agreement and will fairly
reflect the nature of the CRADA Subject Invention, the relative contributions of the Parties to the CRADA Subject Invention and the CRADA, a plan for the development and marketing of the CRADA Subject Invention, the risks incurred by Collaborator,
and the costs of subsequent research and development needed to bring the CRADA Subject Invention to the marketplace. The field of use of the license will not exceed the scope of the Research Plan. 

 

	7.3	Exercise of Collaborator’s License Option. To exercise the option of Paragraph 7.2 Collaborator must submit a written notice to the PHS Patenting and
Licensing Contact identified on the Contacts Information Page (and provide a copy to the ICD Contact for CRADA Notices) within three (3) months after either (i) Collaborator receives written notice from PHS that the Patent Application has
been filed or (ii) the date on which Collaborator files the Patent Application. The written notice exercising this option will include a completed “Application for License to Public Health Service Inventions” and will initiate a
negotiation period that expires nine (9) months after the exercise of the option. If PHS has not responded in writing to the last proposal by Collaborator within this nine (9) month period, the negotiation period will be extended to expire
one (1) month after PHS so responds, during which month Collaborator may accept in writing the final license proposal of PHS. In the absence of Collaborator’s exercise of the option, or upon election of a nonexclusive license, PHS will be
free to license the CRADA Subject Invention to others. These time periods may be extended at the sole discretion of PHS upon good cause shown in writing by Collaborator. 

 

	7.4	Government License in ICD Sole CRADA Subject Inventions and Joint CRADA Subject Inventions. Pursuant to 15 U.S.C. § 3710a(b)(1)(A), for CRADA Subject
Inventions owned solely by ICD or jointly by ICD and Collaborator, and licensed pursuant to the option of Paragraph 7.2, Collaborator grants to the Government a nonexclusive, nontransferable, irrevocable,
paid-up license to practice the CRADA Subject Invention or have the CRADA Subject Invention practiced throughout the world by or on behalf of the Government. In the exercise of this license, the Government
will not publicly disclose trade secrets or commercial or financial information that is privileged or confidential within the meaning of 5 U.S.C. § 552(b)(4) or which would be considered privileged or confidential if it had been obtained from a
non-federal party. 

  

	7.5	Government License in Collaborator Sole CRADA Subject Inventions. Pursuant to 15 U.S.C. § 3710a(b)(2), for CRADA Subject Inventions made solely by an
employee of Collaborator, Collaborator grants to the Government a nonexclusive, nontransferable, irrevocable, paid-up license to practice the CRADA Subject Invention or have the CRADA Subject Invention
practiced throughout the world by or on behalf of the Government for research or other Government purposes. 

  

					
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	7.6	Third Party License. Pursuant to 15 U.S.C. § 3710a(b)(1)(B), if PHS grants Collaborator an exclusive license to a CRADA Subject Invention made solely by an
ICD employee or jointly with a Collaborator employee, the Government will retain the right to require Collaborator to grant to a responsible applicant a nonexclusive, partially exclusive, or exclusive sublicense to use the CRADA Subject Invention in
Collaborator’s licensed field of use on terms that are reasonable under the circumstances; or, if Collaborator fails to grant a license, to grant a license itself. The exercise of these rights by the Government will only be in exceptional
circumstances and only if the Government determines (i) the action is necessary to meet health or safety needs that are not reasonably satisfied by Collaborator, (ii) the action is necessary to meet requirements for public use specified by
federal regulations, and such requirements are not reasonably satisfied by Collaborator; or (iii) Collaborator has failed to comply with an agreement containing provisions described in 15 U.S.C. § 3710a(c)(4)(B). The determination made by
the Government under this Paragraph is subject to administrative appeal and judicial review under 35 U.S.C. § 203(2). 

  

	7.7	Third-Party Rights In ICD Sole CRADA Subject Inventions. For a CRADA Subject Invention conceived prior to the Effective Date solely by an ICD employee that is
first actually reduced to practice after the Effective Date in the performance of the Research Plan, the option offered to Collaborator in Paragraph 7.2 may be restricted if, prior to the Effective Date, PHS had filed a Patent Application and has
either offered or granted a license in the CRADA Subject Invention to a third party. Collaborator nonetheless retains the right to apply for a license to any such CRADA Subject Invention in accordance with the terms and procedures of 35 U.S.C.
§ 209 and 37 C.F.R. Part 404. 

  

	7.8	Joint CRADA Subject Inventions Not Exclusively Licensed by Collaborator. If Collaborator does not acquire an exclusive commercialization license in a joint CRADA
Subject Invention in all fields of use then, for those fields of use not exclusively licensed to Collaborator, each Party will have the right to use the joint CRADA Subject Invention and to license its use to others, and each Party will cooperate
with the other, as necessary, to fulfill international licensing requirements. The Parties may agree to a joint licensing approach for any remaining fields of use. 

 Article 8 Rights of Access and Publication 
  

	8.1	Right of Access to CRADA Data and CRADA Materials. ICD and Collaborator agree to exchange all CRADA Data and to share all CRADA Materials. If the CRADA is
terminated, both Parties agree to provide CRADA Materials in quantities needed to complete the Research Plan. Such provision will occur before the termination date of the CRADA or sooner, if required by the Research Plan. If Collaborator possesses
any human biological specimens from clinical trials under the CRADA, the specimens must be handled as described in the Protocol or as otherwise directed by ICD before the termination date of the CRADA. 

  

					
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	8.2	Use of CRADA Data and CRADA Materials. The Parties will be free to utilize CRADA Data and CRADA Materials internally for their own purposes, consistent with
their obligations under this CRADA. The Parties may share CRADA Data or CRADA Materials with their Affiliates, agents or contractors provided the obligations of this Article 8.2 are simultaneously conveyed. 

 

	 	8.2.1 	CRADA Data. 

 Collaborator
and ICD will use reasonable efforts to keep CRADA Data confidential until published or until corresponding Patent Applications are filed. To the extent permitted by law, each Party will have the right to use any and all CRADA Data in and for any
regulatory filing by or on behalf of the Party. 
  

	 	8.2.2  	CRADA Materials. 

Collaborator and ICD will use reasonable efforts to keep descriptions of CRADA Materials confidential until published or until
corresponding Patent Applications are filed. Collaborator acknowledges that the basic research mission of PHS includes sharing with third parties for further research those research resources made in whole or in part with NIH funding. Consistent
with this mission and the tenets articulated in “Sharing of Biomedical Research Resources: Principles and Guidelines for Recipients of NIH Research Grants and Contracts”, December 1999, available at
http://ott.od.nih.gov/NewPages/RTguide_final.html, following publication either Party may make available to third parties for further research those CRADA Materials made jointly by both PHS and Collaborator. Notwithstanding the above, if those joint
CRADA Materials are the subject of a pending Patent Application or a Patent, or were created using a patent-pending or patented material or technology, the Parties may agree to restrict distribution or freely distribute them. Either Party may
distribute those CRADA Materials made solely by the other Party only upon written consent from that other Party or that other Party’s designee. 
  

	8.3	Confidential Information. Each Party agrees to limit its disclosure of Confidential Information to the amount necessary to carry out the Research Plan, and will
place a confidentiality notice on all this information. A Party orally disclosing Confidential Information to the other Party will summarize the disclosure in writing and provide it to the other Party within fifteen (15) days of the disclosure.
Each Party receiving Confidential Information agrees to use it only for the purposes described in the Research Plan. Either Party may object to the designation of information as Confidential Information by the other Party. 

 

	8.4	Protection of Confidential Information. Confidential Information will not be disclosed, copied, reproduced or otherwise made available to any other person or
entity without the consent of the owning or providing Party except as required by a court or administrative body of competent jurisdiction, or federal law or regulation. Each Party agrees to use reasonable efforts to maintain the confidentiality of
Confidential Information, which will in no instance be less effort than the Party uses to protect its own Confidential Information. Each Party agrees that a Party receiving Confidential Information will not 

  

					
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 be liable for the disclosure of that portion of the Confidential Information which,
after notice to and consultation with the disclosing Party, the receiving Party determines may not be lawfully withheld, provided the disclosing Party has been given a reasonable opportunity to seek a court order to enjoin disclosure. 

 

	8.5	Human Subject Protection. The research to be conducted under this CRADA involves Human Subjects or human tissues within the meaning of 45 C.F.R. Part 46, and all
research to be performed under this CRADA will conform to applicable federal laws and regulations. Additional information is available from the HHS Office for Human Research Protections (http://www.hhs.gov/ohrp/). 

 

	8.6	Duration of Confidentiality Obligation. The obligation to maintain the confidentiality of Confidential Information will expire at the earlier of the date when
the information is no longer Confidential Information as defined in Article 2 or three (3) years after the expiration or termination date of this CRADA, except for IPI, for which the obligation to maintain confidentiality will extend
indefinitely. Collaborator may request an extension to this term when necessary to protect Confidential Information relating to products not yet commercialized. 

 

	8.7	Publication. The Parties are encouraged to make publicly available the results of their research and development activities. Before either Party submits a paper
or abstract for publication or otherwise intends to publicly disclose information about a CRADA Subject Invention, CRADA Data, or CRADA Materials, the other Party will have thirty (30) days to review proposed manuscripts and three (3) days
to review proposed abstracts to assure that Confidential Information is protected. Either Party may request in writing that the proposed publication or other disclosure be delayed for up to thirty (30) additional days as necessary to file a
Patent Application. 

 Article 9 Representations and Warranties 

 

	9.1	Representations of ICD. ICD hereby represents to Collaborator that: 

 

	 	9.1.1 	ICD has the requisite power and authority to enter into this CRADA and to perform according to its terms, and that ICD’s official signing this CRADA has authority
to do so. 

  

	 	9.1.2 	To the best of its knowledge and belief, neither ICD nor any of its personnel involved in this CRADA is presently subject to debarment or suspension by any agency of
the Government which would directly affect its performance of the CRADA. Should ICD or any of its personnel involved in this CRADA be debarred or suspended during the term of this CRADA, ICD will notify Collaborator within thirty (30) days of
receipt of final notice. 

  

					
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	9.2	Representations and Warranties of Collaborator. Collaborator hereby represents and warrants to ICD that: 

 

	 	9.2.1 	Collaborator has the requisite power and authority to enter into this CRADA and to perform according to its terms, and that Collaborator’s official signing this
CRADA has authority to do so. 

  

	 	9.2.2 	Neither Collaborator nor any of its personnel involved in this CRADA, including Affiliates, agents, and contractors are presently subject to debarment or suspension by
any agency of the Government. Should Collaborator or any of its personnel involved in this CRADA be debarred or suspended during the term of this CRADA, Collaborator will notify ICD within thirty (30) days of receipt of final notice.

  

	 	9.2.3 	Subject to Paragraph 12.3, and if and to the extent Collaborator has agreed to provide funding under Appendix B, Collaborator is financially able to satisfy these
obligations in a timely manner. 

  

	 	9.2.4 	The Test Article provided has been produced in accordance with the FDA’s current Good Manufacturing Practice set out in 21 C.F.R. §§ 210-211 and ICH QA7, and meets the specifications cited in the Certificate of Analysis and Investigator’s Brochure provided. 

 Article 10 Expiration and Termination 
  

	10.1	Expiration. This CRADA will expire on the last date of the term set forth on the Summary Page. In no case will the term of this CRADA extend beyond the term
indicated on the Summary Page unless it is extended in writing in accordance with Paragraph 13.6. 

  

	10.2	Termination by Mutual Consent. ICD and Collaborator may terminate this CRADA at any time by mutual written consent. 

 

	10.3	Unilateral Termination. Either ICD or Collaborator may unilaterally terminate this CRADA at any time by providing written notice at least sixty (60) days
before the desired termination date. ICD may, at its option, retain funds transferred to ICD before unilateral termination by Collaborator for use in completing the Research Plan. If Collaborator terminates this Agreement before the completion of
all approved or active Protocol(s), then Collaborator will supply enough Test Article (and Placebo, if applicable) to complete these Protocol(s) unless termination is for safety concerns. 

 

	10.4	Funding for ICD Personnel. If Collaborator has agreed to provide funding for ICD personnel and this CRADA is mutually or unilaterally terminated by Collaborator
before its expiration, then Collaborator agrees that funds for that purpose will be available to ICD for a period of six (6) months after the termination date or until the expiration date of the CRADA, whichever occurs sooner. If there are
insufficient funds to cover this expense, Collaborator agrees to pay the difference. 

  

					
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	10.5	New Commitments. Neither Party will incur new expenses related to this CRADA after expiration, mutual termination, or a notice of a unilateral termination and
will, to the extent feasible, cancel all outstanding commitments and contracts by the termination date. Collaborator acknowledges that ICD will have the authority to retain and expend any funds for up to one (1) year subsequent to the
expiration or termination date to cover any unpaid costs obligated during the term of the CRADA in undertaking the research and development activities set forth in the Research Plan. 

 

	10.6	Collaborator Failure to Continue Development. If Collaborator suspends development of the Test Article without the transfer of its active development efforts,
assets, and obligations to a third party within ninety (90) days of discontinuation, Collaborator agrees that ICD may continue developing the Test Article. In that event, the following will apply: 

 

	 	10.6.1 	Collaborator agrees to transfer to ICD all information necessary to enable ICD to contract for the manufacture of the Test Article and, unless abandoned for reasons
relating to safety as determined by the data safety monitoring board, to provide the Test Article (and Placebo, if any) in Collaborator’s inventory to ICD. 

 

	 	10.6.2 	Further, Collaborator hereby grants to ICD a nonexclusive, irrevocable, world-wide, paid-up license to practice, or have
practiced for or on behalf of the Government, any Background Invention that Collaborator may currently have or will obtain on the Test Article, its manufacture, or on any method of using the Test Article for the indication(s) described in the
Research Plan, including the right to sublicense to third parties. 

 Article 11 Disputes 

 

	11.1	Settlement. Any dispute arising under this CRADA which is not disposed of by agreement of the CRADA Principal Investigators will be submitted jointly to the
signatories of this CRADA. If the signatories, or their designees, are unable to jointly resolve the dispute within thirty (30) days after notification thereof, the Assistant Secretary for Health (or his/her designee or successor) will propose
a resolution. Nothing in this Paragraph will prevent any Party from pursuing any additional administrative remedies that may be available and, after exhaustion of such administrative remedies, pursuing all available judicial remedies.

  

	11.2	Continuation of Work. Pending the resolution of any dispute or claim pursuant to this Article 11, the Parties agree that performance of all obligations will be
pursued diligently. 

  

					
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 Article 12 Liability 

 

	12.1	NO WARRANTIES. EXCEPT AS SPECIFICALLY STATED IN ARTICLE 9, THE PARTIES MAKE NO EXPRESS OR IMPLIED WARRANTY AS TO ANY MATTER WHATSOEVER, INCLUDING THE CONDITIONS
OF THE RESEARCH OR ANY INVENTION OR MATERIAL, WHETHER TANGIBLE OR INTANGIBLE, MADE OR DEVELOPED UNDER OR OUTSIDE THE SCOPE OF THIS CRADA, OR THE OWNERSHIP, MERCHANTABILITY, OR FITNESS FOR A PARTICULAR PURPOSE OF THE RESEARCH OR ANY INVENTION OR
MATERIAL, OR THAT A TECHNOLOGY UTILIZED BY A PARTY IN THE PERFORMANCE OF THE RESEARCH PLAN DOES NOT INFRINGE ANY THIRD-PARTY PATENT RIGHTS. 

  

	12.2	Indemnification and Liability. Collaborator agrees to hold the Government harmless and to indemnify the Government for all liabilities, demands, damages,
expenses and losses arising out of the use by Collaborator for any purpose of the CRADA Data, CRADA Materials or CRADA Subject Inventions produced in whole or part by ICD employees under this CRADA, unless due to the negligence or willful misconduct
of ICD, its employees, or agents. The Government has no statutory authority to indemnify Collaborator. Each Party otherwise will be liable for any claims or damages it incurs in connection with this CRADA, except that ICD, as an agency of the
Government, assumes liability only to the extent provided under the Federal Tort Claims Act , 28 U.S.C. Chapter 171. 

  

	12.3	Force Majeure. Neither Party will be liable for any unforeseeable event beyond its reasonable control and not caused by its own fault or negligence, which
causes the Party to be unable to perform its obligations under this CRADA, and which it has been unable to overcome by the exercise of due diligence. If a force majeure event occurs, the Party unable to perform will promptly notify the other
Party. It will use its best efforts to resume performance as quickly as possible and will suspend performance only for such period of time as is necessary as a result of the force majeure event. 

Article 13 Miscellaneous 
  

	13.1	Governing Law. The construction, validity, performance and effect of this CRADA will be governed by U.S. federal law, as applied by the federal courts in the
District of Columbia. If any provision in this CRADA conflicts with or is inconsistent with any U.S. federal law or regulation, then the U.S. federal law or regulation will preempt that provision. 

 

	13.2	Compliance with Law. ICD and Collaborator agree that they will comply with, and advise any contractors, grantees, or agents they have engaged to conduct the
CRADA research and development activities to comply with, all applicable Executive Orders, statutes, and HHS regulations relating to research on human subjects (45 C.F.R. Part 46, 21 C.F.R. Parts 50 and 56) and relating to the appropriate care and
use of laboratory 

  

					
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 animals (7 U.S.C. § 2131 et seq.; 9 C.F.R. Part 1, Subchapter A). ICD and
Collaborator will advise any contractors, grantees, or agents they have engaged to conduct clinical trials for this CRADA that they must comply with all applicable federal regulations for the protection of Human Subjects, which may include the
Standards for Privacy of Individually Identifiable Health Information set forth in 45 C.F.R. Part 164. Collaborator agrees to ensure that its employees, contractors, and agents who might have access to a “select agent or toxin” (as that
term is defined in 42 C.F.R. §§ 73.4-73.5) transferred from ICD is properly licensed to receive the “select agent or toxin”. 
  

	13.3	Waivers. None of the provisions of this CRADA will be considered waived by any Party unless a waiver is given in writing to the other Party. The failure of a
Party to insist upon strict performance of any of the terms and conditions hereof, or failure or delay to exercise any rights provided herein or by law, will not be deemed a waiver of any rights of any Party. 

 

	13.4	Headings. Titles and headings of the articles and paragraphs of this CRADA are for convenient reference only, do not form a part of this CRADA, and will in no
way affect its interpretation. 

  

	13.5	Severability. The illegality or invalidity of any provisions of this CRADA will not impair, affect, or invalidate the other provisions of this CRADA.

  

	13.6	Amendments. Minor modifications to the Research Plan may be made by the mutual written consent of the CRADA Principal Investigators. Substantial changes to the
CRADA, extensions of the term, or any changes to Appendix C will become effective only upon a written amendment signed by the signatories to this CRADA or by their representatives duly authorized to execute an amendment. A change will be considered
substantial if it directly expands the range of the potential CRADA Subject Inventions, alters the scope or field of any license option governed by Article 7, or requires a significant increase in the contribution of resources by either Party.

  

	13.7	Assignment. Neither this CRADA nor any rights or obligations of any Party hereunder will be assigned or otherwise transferred by either Party without the prior
written consent of the other Party. This CRADA will be binding upon and inure to the benefit of the Parties and their respective successors and permitted assigns. 

 

	13.8	Notices. All notices pertaining to or required by this CRADA will be in writing, signed by an authorized representative of the notifying Party, and delivered by
first class, registered, or certified mail, or by an express/overnight commercial delivery service, prepaid and properly addressed to the other Party at the address designated on the Contacts Information Page, or to any other address designated in
writing by the other Party. Notices will be considered timely if received on or before the established deadline date or sent on or before the deadline date as verifiable by U.S. Postal Service postmark or dated receipt from a commercial carrier.
Notices regarding the exercise of license options will be made pursuant to Paragraph 7.3. Either Party may change its address by notice given to the other Party in the manner set forth above. 

  

					
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	13.9 	Independent Contractors. The relationship of the Parties to this CRADA is that of independent contractors and not agents of each other or joint venturers or
partners. Each Party will maintain sole and exclusive control over its personnel and operations. 

  

	13.10 	Use of Name; Press Releases. By entering into this CRADA, the Government does not directly or indirectly endorse any product or service that is or will be
provided, whether directly or indirectly related to either this CRADA or to any patent or other intellectual-property license or agreement that implements this CRADA by Collaborator, its successors, assignees, or licensees. Collaborator will not in
any way state or imply that the Government or any of its organizational units or employees endorses any product or services. Each Party agrees to provide proposed press releases that reference or rely upon the work under this CRADA to the other
Party for review and comment at least five (5) business days before publication. Either Party may disclose the Title and Abstract of the CRADA to the public without the approval of the other Party. 

 

	13.11 	Reasonable Consent. Whenever a Party’s consent or permission is required under this CRADA, its consent or permission will not be unreasonably withheld.

  

	13.12 	Export Controls. Collaborator agrees to comply with U.S. export law and regulations. If Collaborator has a need to transfer any CRADA Materials made in whole or
in part by ICD, or ICD Materials, or ICD’s Confidential Information to a person located in a country other than the United States, to an Affiliate organized under the laws of a country other than the United States, or to an employee of
Collaborator in the United States who is not a citizen or permanent resident of the United States, Collaborator will acquire any and all necessary export licenses and other appropriate authorizations. 

 

	13.13 	Entire Agreement. This CRADA constitutes the entire agreement between the Parties concerning the subject matter of this CRADA and supersedes any prior
understanding or written or oral agreement. 

  

	13.14 	Survivability. The provisions of Paragraphs 3.3, 3.4, 3.8, 4.2, 4.3, 5.3, 5.4, 6.1-9.2, 10.3-10.6, 11.1, 11.2, 12.1-12.3,
13.1-13.3, 13.7, 13.10 and 13.14 will survive the expiration or early termination of this CRADA. 

 SIGNATURES
BEGIN ON THE NEXT PAGE 

  

					
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 PUBLIC HEALTH SERVICE 

COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT

 FOR INTRAMURAL-PHS CLINICAL
RESEARCH 
 SIGNATURE PAGE 
 ACCEPTED AND AGREED 
 BY EXECUTING THIS
AGREEMENT, EACH PARTY REPRESENTS THAT ALL STATEMENTS MADE HEREIN ARE TRUE,
COMPLETE, AND ACCURATE TO THE BEST OF ITS KNOWLEDGE. COLLABORATOR ACKNOWLEDGES
THAT IT MAY BE SUBJECT TO CRIMINAL, CIVIL, OR ADMINISTRATIVE PENALTIES
FOR KNOWINGLY MAKING A FALSE, FICTITIOUS, OR FRAUDULENT STATEMENT OR CLAIM,

  

					
	FOR ICD:	  		  	
			
	 /s/ Anna D. Barker
	  		  	 4/29/08

	Signature	  		  	Date
			
	Typed Name: Anna D. Barker, Ph.D.	  		  	
	Title: Deputy Director, NCI	  		  	

  

					
	FOR COLLABORATOR:	  		  	
			
	 /s/ Jeffrey Rona
	  		  	 5/8/08

	Signature	  		  	Date
			
	Typed Name: Jeffrey Rona	  		  	
	Title: Chief Business Officer	  		  	

  

					
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 PUBLIC HEALTH SERVICE 

COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT

 FOR INTRAMURAL-PHS CLINICAL
RESEARCH 
 CONTACTS INFORMATION PAGE 
 CRADA Notices 
  

			
	For ICD:	  	For Collaborator:
		
	Technology Transfer Center	  	Chief Medical Officer
	National Cancer Institute	  	Attn: Dr. David Apelian
	Rockville, MD 20852	  	1450 Infinite Dr.
	Phone: 301-496-0477	  	Louisville, CO 80027
	Fax: 301-402-2117	  	Phone: 303-625-2860
		  	Fax: 303-625-2710

 Patenting and Licensing 

 

			
	For ICD:	  	For Collaborator (if separate from above):
		
	Division Director, Division of Technology Development and Transfer	  	Chief Medical Officer
	NIH Office of Technology Transfer	  	Attn: Jeffrey Rona
	6011 Executive Boulevard, Suite 325	  	1450 Infinite Dr.
	Rockville, Maryland 20852-3804	  	Louisville, CO 80027
	Tel: 301-496-7057	  	Phone: 303-625-2720
	Fax: 301-402-0220	  	Fax: 303-625-2710

 Delivery of Materials Identified In Appendix B (if any) 

 

			
	For ICD:	  	For Collaborator:
		
	Dr. Jeffrey Schlom	  	Vice President Research & Development
	10 Center Drive, MSC 1750	  	Attn: Dr. Alex Franzusoff
	Building 10, Room 8B09	  	1450 Infinite Dr.
	Bethesda, MD 20892	  	Louisville, CO 80027
	Phone: 301-496-4343	  	Phone: 303-625-2830
	Fax: 301-496-2726	  	Fax: 303-625-2710
	Email: js141c@nih.gov	  	Email: alex.franzusoff@globeimmune.com

  

					
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 PUBLIC HEALTH SERVICE 

COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT

 FOR INTRAMURAL-PHS CLINICAL
RESEARCH 
 CONTACTS INFORMATION PAGE 
 CRADA Notices 
 SUMMARY PAGE 

EITHER PARTY MAY, WITHOUT FURTHER CONSULTATION OR PERMISSION, 

RELEASE THIS SUMMARY PAGE TO THE PUBLIC. 
 TITLE OF CRADA: Preclinical and Clinical Development of GlobeImmune, Inc.’s Proprietary Yeast-Based Tarmogens Expressing Tumor-Associated Antigens for Cancer Immunotherapy 

 

			
	 PHS [ICD] Component:

ICD CRADA Principal Investigator:
	  	 National Cancer Institute, NIH
 Jeffrey Schlom, Ph.D.

		
	 Collaborator:
 Collaborator
CRADA Principal Investigator:
	  	 GlobeImmune, Inc.
 Alex
Franzusoff, Ph.D.

		
	Term of CRADA:	  	Five (5) years from the Effective Date

 ABSTRACT OF THE RESEARCH PLAN: 
 GlobeImmune, Inc. and the National Cancer Institute, National Institutes of Health, will collaborate under a Cooperative Research and Development Agreement on the preclinical and clinical development of
GlobeImmune’s proprietary yeast-based Tarmogens expressing tumor-associated antigens as potential vaccines for the prevention and/or therapy of a range of human cancers. 

  

					
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 PUBLIC HEALTH SERVICE 

COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT

 FOR INTRAMURAL-PHS CLINICAL
RESEARCH 
 APPENDIX A 
 RESEARCH PLAN 
 TITLE OF CRADA 

Preclinical and Clinical Development of GlobeImmune, Inc.’s Proprietary Yeast-Based 

Tarmogens Expressing Tumor-Associated Antigens for Cancer Immunotherapy 

NCI, NIH Principal Investigator 
 Jeffrey Schlom, Ph.D. 
 Laboratory of Tumor Immunology and Biology (LTIB), Center
for Cancer Research 
 (CCR), National Cancer Institute (NCI) 

Collaborator Principal Investigator 
 Alex Franzusoff, Ph.D. 
 Vice-President of Research and Development 

GlobeImmune, Inc. 

Term of CRADA 
 Five (5) years from the Effective Date. 
 GOAL OF THIS CRADA

 The principal goal of this CRADA is to evaluate the potential therapeutic benefit of administering GlobeImmune, Inc.’s proprietary
whole recombinant heat-killed yeast vaccine (referred to herein as “Tarmogens” ((Targeted Molecular Immunogens)) expressing NCI-supplied tumor antigens for the treatment and/or
prevention of cancer in animals and in humans. Activities under this CRADA will involve the cooperation and collaboration of LTIB at NCI and the Division of Cancer Treatment and Diagnosis (DCTD) at NCI. 

The subject matter of this CRADA including any in vitro and in vivo testing conducted by Dr. Jeffrey Schlom is strictly limited to the
development of vaccines that utilize NCI’s proprietary tumor associated antigens and GlobeImmune, Inc.’s proprietary Tarmogens. 
 The
objectives of this CRADA will be divided into two parts: 
  

	Part I:	Preclinical Studies: 

 In
vitro studies will be performed to investigate the immunogenicity of Tarmogens expressing NCI’s proprietary tumor-associated antigens (TAAs). These TAAs include Carcinoembryonic Antigen (CEA), Brachyury, [*] point mutated ras, [*]. These
recombinant Tarmogens expressing tumor antigens will be produced and supplied to NCI by GlobeImmune, Inc. 
 In vivo
studies will be performed by NCI to test the immunogenicity of mutually selected recombinant Tarmogens in preclinical animal models. The data will be shared with GlobeImmune, Inc. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

	Part II:	Clinical Studies: 

 NCI and
GlobeImmune, Inc. will jointly evaluate all preclinical data and based upon these results, clinical studies will be planned and conducted with the recombinant Tarmogens specified in the applicable Protocol as mutually agreed upon by the parties. NCI
will conduct Phase I and Phase 2 clinical studies of Tarmogens expressing CEA [*]. 
 Future clinical studies may also be
conducted under GlobeImmune sponsored INDs by mutual agreement of the Parties. 
 INTRODUCTION 

Dr. Jeffrey Schlom and his colleagues at the LTIB have developed a number of preclinical models and vaccine strategies to investigate the
therapeutic benefits of cancer vaccines against cancer. In these approaches, TAAs which are primarily expressed in human tumor cells and not expressed or minimally expressed in normal tissues have been employed to generate a tumor-specific immune
response that results in tumor destruction. The LTIB scientists have extensive experience in preclinical models in the analysis of immune responses directed against a range of TAAs. They have the demonstrated ability to analyze a range of immune
cell subsets, including CD4, CDS, Natural Killer (NK), and regulatory T cells. 
 The LTIB scientists also have extensive experience in:
(A) The development and use of animal models to analyze both the immune response and the therapeutic efficacy of cancer vaccines. They have developed animal models in which the tumors express self antigens so that one can assess the ability of
a vaccine to break immune tolerance. They have also developed animal models involving subcutaneous tumors, lung metastasis, orthotopic renal cell cancers, and spontaneous mammary carcinomas. (B) The design and evaluation of vaccine combination
therapy regimens, including the use of vaccines with chemotherapeutic agents, small molecule targeted therapeutics, monoclonal antibodies, external beam radiation, chelated radionuclides, and cytokines. (C) The modification of human TAAs to
enhance their immunogenicity and in the development of subsequent agonist epitopes of those TAAs]. (D) The analysis of human TAAs for their ability to activate human T-cell responses in vitro.
(E) The planning and carrying out of clinical trials involving cancer vaccines as monotherapy or in combination therapies for a range of human cancers. (F) And the analysis of immune responses of patients both pre- and post-vaccination. 
 GlobeImmune, Inc. has developed a unique
technology of recombinant yeast-based vaccines termed Tarmogens. In the context of this CRADA only, Tarmogens are whole, recombinant Saccharomyces cerevisiae yeast genetically modified to express one or more protein targets that stimulate the
immune system against diseased cells. The whole yeast, with the antigen(s) expressed inside, is the product that is administered to the patient. 
 BACKGROUND 
 It has been shown that human tumors express a range of antigens
that are overexpressed or uniquely expressed as compared to normal human adult tissues. This information can be exploited by inducing the immune system to generate an immune response to these TAAs by the use of recombinant vaccines expressing these
TAAs. One of the major problems of this approach, however, is that many of these “self” antigens are weakly immunogenic. Thus, strategies must be developed in which the presentation of these antigens to the immune system results in far
greater activation of immune responses than would be achieved naturally in the host. The generation of a vehicle that would enhance the presentation of a given TAA to the immune system would be a major step forward toward the development of a
vaccine for the therapy and/or prevention of a range of human cancers. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 Yeast delivered tumor antigens activate innate immunity as well as antigen-specific immune responses.
The use of yeast-based vaccines has been shown to be effective for cancer immunotherapy in preclinical animal models. A Phase I trial performed by GlobeImmune, Inc., outside the scope of this CRADA, demonstrated that administering GI-4000 yeast Tarmogens expressing a mutated Ras gene was well-tolerated (i.e. no drug-related serious adverse events; only adverse events confined to self-resolving injection
site reactions and mild constitutional symptoms) and was immunogenic in 33 subjects with metastatic colorectal and pancreas cancer. Additionally, two other clinical studies, outside the scope of this CRADA, are being performed by GlobeImmune, Inc. A
randomized, placebo-controlled Phase 2 trial is underway at multiple centers to test GI-4000 mutated Ras-expressing yeast in combination with adjuvant gemcitabine in
subjects with newly resected pancreas cancer. In addition, the GI-5005 yeast Tarmogen expressing two hepatitis C virus (HCV) proteins is being tested in a randomized, placebo-controlled Phase 1b trial in
subjects with chronic HCV infection. The interim results from that trial confirm that administration of yeast-based immunotherapeutic products is well-tolerated and immunogenic for yeast-expressed antigens in humans. The dual contributions to immune
activation arise from the inherent “adjuvant-like” properties of yeast combined with direct delivery of the expressed tumor antigen for processing and presentation to the immune system. 

GlobeImmune, Inc. and the LTIB, have recently carried out a series of collaborative studies on the generation and analysis of
yeast-based vaccines in preclinical models under a CRADA Letter of Intent (LOI) that was executed August 15, 2007. This has resulted in a recently completed study, submitted for publication, which demonstrated the effects of treatment with
recombinant yeast on murine immature dendritic cells (DCs). Yeast expressing human CEA as a model antigen was studied. CEA is overexpressed in a number of epithelial ductal cancers, including non-small cell
lung, gastrointestinal (colorectal, pancreas), breast, and ovarian cancers. Injection of mice subcutaneously with yeast-CEA resulted in rapid increases in Major Histocompatibility Complex (MHC) class II+ cells and total antigen-presenting cells in draining lymph nodes.
Post-treatment with yeast-CEA, DCs rapidly elevated both MHC class I and II, numerous costimulatory molecules and other DC maturation markers, and secreted a range of Type I inflammatory cytokines. Gene expression arrays also revealed the rapid up-regulation of numerous cytokine and chemokine mRNAs, as well as genes involved in signal transduction and antigen uptake. Functional studies demonstrated enhanced allospecific reactivity of DCs following
treatment with yeast-CEA or control yeast. Lastly, treatment of DCs with yeast-CEA resulted in specific activation of
CEA-specific CDS+ T cells in an MHC-restricted manner. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 In a second study conducted under the LOI, experiments were performed to determine
if vaccination of CEA-transgenic mice (wherein CEA is a self-antigen) with yeast-CEA elicits CEA-specific T-cell responses and antitumor activity; these results have recently been submitted for publication. CEA-transgenic mice were vaccinated with yeast-CEA, and CD4+ and CD8+ T-cell responses were assessed after one and multiple administrations or
vaccinations at multiple sites per administration. Antitumor activity was determined by tumor growth and overall survival in both pulmonary metastasis and subcutaneous pancreatic tumor models. These studies demonstrated that recombinant yeast can
indeed break tolerance and that a) yeast-CEA constructs can elicit both CEA-specific CD4+ and CD8+ T-cell responses; b) repeated yeast-CEA
administration causes increased antigen-specific T-cell responses after each vaccination; c) vaccination with yeast-CEA at multiple sites induces a greater T-cell response than the same dose given at a single site; and d) tumor-bearing mice vaccinated with yeast-CEA show a reduction in tumor burden and increased overall survival
compared to mock-treated or control yeast-vaccinated mice in both pulmonary metastasis and subcutaneous pancreatic tumor models. Thus vaccination with a heat-killed recombinant yeast construct expressing the tumor-associated antigen CEA induces CEA-specific immune responses, reduces tumor burden, and extends overall survival in CEA-transgenic mice. These studies thus support the rationale for the incorporation of
recombinant yeast-CEA and other recombinant yeast constructs in cancer immunotherapy protocols. 
 In
recent studies conducted under the LOI (manuscript in preparation), it was demonstrated that yeast-CEA is extremely efficient in activating human DCs. Yeast-CEA treated
human DCs were shown to upregulate a range of human T-cell costimulatory molecules and to increase the expression of a range of proinflammatory cytokines, including
IL-12, TNF-alpha, and interferon-gamma. Gene expression profiles of human DCs treated with yeast-CEA revealed increased
expression of numerous genes involved in the production of chemokines, cytokines, and genes related to antigen uptake, antigen presentation and signal transductions. It was also demonstrated that human DCs treated with
yeast-CEA can activate CEA-specific human T-cell lines capable of lysing human tumor cells expressing CEA. Collectively, the
three studies described above support the scientific rationale for the use of recombinant yeast in vaccination protocols for cancer or infectious diseases. 
 WORK SCOPE OF CRADA 
  

	Part I:	Preclinical Studies 

In vitro studies: 
 In vitro studies will be performed to investigate the immunogenicity of Tarmogens expressing NCI’s proprietary TAAs and GI 4000 Tarmogen expressing point mutated ras. [*] 

 

	 	•	 	 [*] 

  

	 	•	 	 [*] several additional mutually agreeable tumor antigens supplied by NCI will be engineered by GlobeImmune, Inc. into Tarmogens for preclinical
evaluation at NCI and at GlobeImmune, Inc. These genes include Brachyury, [*]. 

  

	 	•	 	 GI-4000 Tarmogens expressing point mutated ras developed at GlobeImmune, Inc. will be supplied to NCI for pre-clinical studies.

  

	 	•	 	 [*] 

 In
vivo studies: 
 In vivo studies will be performed by [*] to test the immunogenicity of mutually selected recombinant
Tarmogens in preclinical animal models. [*] will investigate the immunogenicity of Tarmogens expressing CEA and other mutually agreed upon yeast recombinant vaccines in several NCI-developed animal models, [*]: 

 

	 	•	 	 [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; and 

  

	 	•	 	 [*]. 

 [*]

 GlobeImmune, Inc. will engineer Tarmogens to optimally express CEA and other mutually agreed upon tumor-associated antigens
and will provide sufficient amounts of the Tarmogens to [*] to enable [*] to perform the necessary preclinical studies. 
  

	Part II:	Clinical Studies 

 [*] will
conduct Phase 1 and Phase 2 studies of GMP manufactured Tarmogens expressing CEA, supplied by GlobeImmune, Inc., [*]. [*] will submit and file an IND with the FDA and sponsor the Phase 1 and Phase 2 clinical studies of the Tarmogens expressing CEA.
Clinical studies of Tarmogens expressing other tumor antigens will be planned and conducted based upon the results of the preclinical studies and as mutually agreed upon by the Parties [*]. 
 [*] 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 DESCRIPTION OF THE CONTRIBUTIONS AND RESPONSIBILITIES OF 

THE PARTIES 

Contributions of GlobeImmune Inc. 
  

	 	•	 	 Engineer Tarmogens to express CEA [*], Brachyury, [*]; 

 

	 	•	 	 [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; and 

  

	 	•	 	 [*]. 

 [*] 

 

	 	•	 	 [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; and 

  

	 	•	 	 [*]. 

 Contributions of
GlobeImmune, Inc. and NCI 
  

	 	•	 	 Conduct in vitro preclinical studies of mutually agreeable Tarmogens expressing antigens of genes supplied by NCI (including those expressing
Brachyury, [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; and 

  

	 	•	 	 Plan and conduct clinical studies of recombinant yeast vaccines expressing other antigens based upon the results of preclinical studies and as mutually
agreed upon by the parties [*]. 

 [*] 

 

	 	•	 	 [*]; 

  

	 	•	 	 [*]; 

  

	 	•	 	 [*]; and 

  

	 	•	 	 [*] 

DESCRIPTION OF RELATED NCI-GLOBEIMMUNE, INC. AGREEMENTS 

There are no active Cooperative Research and Development Agreements (CRADAs) between NCI and GlobeImmune, Inc. 

The Letter of Intent for CRADA #02264 that was executed on August 15, 2007 (expiration date of August 15, 2008, amendment to LOI extended term
for additional six months) by GlobeImmune, Inc. and NCI and the four agreements that were superseded by the Letter of Intent are superseded and succeeded by the terms of this CRADA upon execution of the CRADA. 

The agreements that were previously superseded by the Letter of Intent include: 

 

	 	1)	Material Transfer Agreement # 1-23623-07 

Materials: A2 CEA tetramer and A2 mesothelin tetramer 
 NCI PI: Jeffrey Schlom 
 Execution Date: May 11, 2007 

 

	 	2)	Collaboration Agreement #1-23090-07 

Materials: mesothelin, NGEP, CAP-C, and brachyury antigen cDNAs; and 

MLV gp70 plasmid 

NCI PI: Jeffrey Schlom 
 Expiration Date: June 1, 2008 
  

	 	3)	Collaboration Agreement #1-17530-04 

Materials: CEA cDNA clone 
 NCI: PI Jeffrey Schlom 
 Expiration Date: August 2, 2006 

 

	 	4)	Confidential Disclosure Agreement # 2-05675-07 

Project: Yeast based vaccines for immunotherapy 
 NCI PI: Jeffrey Schlom 
 Expiration Date: October 11, 2009 

INTELLECTUAL PROPERTY OF THE PARTIES 
 [*] 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 REFERENCES 
 [*] 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

			
	CONFIDENTIAL	  	GlobeImmune, Inc.-NCI CRADA # 02264

 PUBLIC HEALTH SERVICE 

COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT

 FOR INTRAMURAL-PHS CLINICAL
RESEARCH 
 APPENDIX B 
 STAFFING, FUNDING AND MATERIALS/EQUIPMENT CONTRIBUTIONS 
 OF THE PARTIES 

Staffing Contributions: 

[*] 
 Clinical Data Collection
Support: 
 [*] 

Support for IB Distribution, IND and IND Amendments: 
 [*] 
 Funding Contributions: 

[*] 
 Materials/Equipment
Contributions: 
 [*] 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

  

			
	CONFIDENTIAL	  	GlobeImmune, Inc.-NCI CRADA # 02264

 PUBLIC HEALTH SERVICE 

COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT

 FOR INTRAMURAL-PHS CLINICAL
RESEARCH 
 APPENDIX C 
 MODIFICATIONS TO THE MODEL INTRAMURAL-PHS CLINICAL CRADA 
 (Additions are indicated by underline, deletions by strike-out) 
 Amend Article 1 to read as
follows: 
 Article  1. Introduction 
 This CRADA between ICD and Collaborator will be effective when signed by the Parties, which are identified on both the Cover Page and the Signature Page (page 21). The official contacts for the Parties
are identified on the Contacts Information Page (page 22). Publicly available information regarding this CRADA appears on the Summary Page (page 23). The research and development activities that will be undertaken by ICD and Collaborator in the
course of this CRADA are detailed in the Research Plan, attached as Appendix A. The staffing, funding, and materials contributions of the Parties are set forth in Appendix B. Any changes to the model CRADA are set forth in Appendix C. A Letter of
Intent (“LOI”) to enter into this CRADA was executed by the Parties, as of August 15, 2007, which LOI is attached hereto as Appendix D. Articles 2, 6, 7, 8, and 9 of the Model PHS CRADA shall be deemed to have become effective between
the Parties on the date of execution of the LOI and shall survive through the Effective Date of this CRADA; provided, that as of the Effective Date, such LOI and the Model PHS CRADA terms shall be of no further force or effect and shall be
superseded by the terms of this CRADA. The Research Plan of this CRADA hereby replaces and supersedes the Research Plan of the LOI.  

Amend, Delete, or Add the following definitions in Article 2, as applicable: 
 “Confidential Information” means confidential scientific, business, financial information, or Identifiable Private Information provided that the information does not include: 

 

	 	(a)	information that is publicly known or that is available from public sources; 

 

	 	(b)	information that has been made available by its owner to others without a confidentiality obligation; 

 

	 	(c)	information that is already known by the receiving Party, or information that is independently created or compiled by the receiving Party without reference to or use of
the provided information; or 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

	 	(d)	information that relates to potential hazards or cautionary warnings associated with the production, handling, or use of the subject matter of the Research Plan

 ; in each case, to the extent shown by the receiving Party through competent written
evidence. 
 “CRADA Year” means for the initial year of this CRADA, the time period beginning on the Effective Date and
ending twelve (12) months thereafter, and for each subsequent year of this CRADA, shall mean the period beginning on the anniversary date of the Effective Date and ending twelve (12) months thereafter. 

“CTEP” means the Cancer Therapy Evaluation Program, DCTD, NCI. “DCTD” means Division of Cancer Treatment and Diagnosis,
NCI. 
 “Party” means either Collaborator or ICD, as applicable, and together Collaborator and ICD may be collectively
referred to herein as the “Parties”. 
 “Protocol” means the formal, detailed description of a clinical
study to be performed as provided for in the Research Plan under this CRADA. It describes the objective(s), design, methodology, statistical considerations, and organization of a trial such clinical study. For the
purposes of this CRADA, the term, Protocol, for clinical research studies involving Human Subjects, includes any and all associated documents, including informed consent forms, to be provided to Human Subjects and potential
participants in the study clinical studies conducted under this CRADA in accordance with the applicable Protocol. 

“Protocol Review Committee” (or PRC) means the CTEP committee that reviews and approves studies involving NCI investigational
agents and/or activities supported by ICD. 
 “Serious Adverse Event” or “SAE” means any AE that
results in death, is life threatening, requires inpatient hospitalization or prolongation of existing hospitalization, results in persistent or significant disability/incapacity, results in a congenital anomaly/ birth defect. 

“Steering Committee” means the research and development team whose composition and responsibilities with regard to the research
performed under this CRADA are described in Appendix A. 
 “Tarmogens” mean GlobeImmune’s whole, recombinant
yeast genetically modified to express one or more protein targets to stimulate the immune system against diseased cells. 
 “Test
Article” means, in accordance with 21 C.F.R. 50.3 (j), any drug (including a biological product), medical device, food additive, color additive, electronic product, or any other article subject to regulation under the Federal Food, Drug,
and Cosmetic Act that is intended for administration to humans or animals, including a drug or biologic, as which for the purposes of the clinical studies to be conducted under this CRADA shall be the Tarmogens identified in the
Research Plan and Appendix B,that is used within the scope-of-the Research Plan. The Test Article may also be referred to as Investigational Agent,
Study Material, or Study Product. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 “Unexpected Adverse Event” means any adverse experience that is not listed in the
current labeling for the biological product. This includes events that may be symptomatically and pathophysiologically related to an event listed in the labeling, but differ from the event because of greater severity or specificity.
“Unexpected”, as used in this definition, refers to an adverse experience that has not been previously observed rather than from the perspective of such experience not being anticipated from the pharmacological properties of the
pharmaceutical product. 
 Amend Article 3.1 to read as follows: 

 

	3.1	Performance of Research and Development. The research and development activities to be carried out under this CRADA will be performed solely by the Parties
identified on the Cover Page and their respective employees, unless specifically stated elsewhere in the Agreement; provided, that Collaborator may use its Affiliates and qualified contractors to perform any of its obligations under this
CRADA. The CRADA PIs will be responsible for coordinating the scientific and technical conduct of this project on behalf of their employers. Any Collaborator employees, Affiliates or contractors who will work at ICD facilities will be
required to sign a Guest Researcher or Special Volunteer Agreement appropriately modified in view of the terms of this CRADA. 

Amend Article 3.6 to read as follows: 
  

	3.6	Clinical Investigator Responsibilities. 

  

	 	3.6.1	The ICD Clinical Investigator will be required to submit, or to arrange for submission of, each Protocol associated with this CRADA to the PRC and
IRB. In addition to the Protocol all associated documents, including informational documents and advertisements, must be reviewed and approved by the PRC and IRB before starting the research. The research clinical
studies will be done performed in strict accordance with the Protocol(s). and no substantive changes in a finalized Protocol will be made unless mutually agreed upon, in writing, by the Parties. Research
will not commence (or will continue unchanged, if already in progress) until each substantive change to a Protocol, including those required by either the FDA or the IRB, has been integrated in a way acceptable to the Parties, submitted to the FDA
(if applicable) and approved by the IRB. Any previously approved Protocol which has been submitted to FDA may be amended as necessary. Minor changes to an approved Protocol will be reviewed and approved by DCTD prior to submission of the
Protocol amendment to the FDA. Substantial changes to a Protocol that impact study design, patient population and drug supply will be discussed with Collaborator prior to CTEP approval and submission to the FDA, when feasible.

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

	 	3.6.2	Each Protocol will be forwarded electronically to Collaborator for review and comment approximately two weeks before it is reviewed by the PRC. Comments from
Collaborator received by ICD before the PRC meeting will be discussed by the PRC, will be given due consideration, and will be incorporated into the Protocol, absent good cause. Comments from either the Collaborator or ICD that are agreed upon in
the PRC meeting will be formatted as a consensus review, which is returned to the Clinical Investigator for necessary and/or suggested changes before the Protocol can be given final approval and submitted to the FDA. A copy of the final approved
Protocol will be forwarded to Collaborator within 24 to 48 hours of its submission to the FDA. 

 Amend Article 3.7 to
read as follows: 
  

	3.7	Investigational New Drug Applications. 

  

	 	3.7.1	If an IND is required, ICD, as indicated in the Research Plan, will be the IND Sponsor and will prepare and submit an
IND. All Clinical Investigators participating in ICD-sponsored clinical trials must have completed registration documents on file (1572 forms) with ICD. 

 

	 	3.7.2	When ICD files the IND, Collaborator agrees to provide ICD background data and information necessary to support the IND. Collaborator further agrees to
provide a letter of cross-reference to all pertinent regulatory filings including an IND and/or DMF sponsored by Collaborator. Collaborator’s employees will be reasonably available to respond to inquiries from the FDA regarding
information and data contained in the Collaborator’s IND, DMF, other filings, or other information and data provided to ICD by the Collaborator pursuant to this Article 3. If ICD has provided information or data to assist Collaborator in its
IND filing, ICD will provide a letter of cross reference to its MD and respond to inquiries related to information provided by ICD, as applicable.  

  

	 	3.7.3	If Collaborator supplies Confidential Information to ICD in support of an IND filed by ICD, this information will be protected in accordance with the corresponding
confidentiality provisions of Article 8. 

  

	 	3.7.4	Collaborator may sponsor its own clinical trials for Tarmogens developed within or outside of the scope of this CRADA and hold its own IND for studies performed
outside the scope of this CRADA or for studies within the scope of this CRADA as may be mutually agreed by the Parties. These studies, however, should not adversely affect the ability to accomplish the goal of the Research Plan, for,
example, by competing for the same study population. All data from those the clinical trials or studies conducted outside the scope of the CRADA by Collaborator are proprietary to Collaborator for purposes of
this CRADA. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 Amend Article 3.8 to read as follows: 

 

	3.8	Test Article Information and Supply. Collaborator agrees to provide ICD without charge and on a schedule that will ensure adequate and timely performance of the
research, a sufficient quantity of formulated and acceptably labeled, clinical-grade Test Article (and, as required by the Protocol(s), Placebo) to complete the clinical trial(s) studies based on the Research Plan and Protocol
mutually agreed to and approved upon by the Parties under this CRADA. ICD will provide to Collaborator at least six (6) months in advance of the required delivery date of such supply. Updated forecasts will be provided
for the amounts of Test Article anticipated for ongoing and anticipated mutually agreed upon clinical studies conducted under this CRADA. Collaborator further agrees to provide draft Investigational Agent labels to the NCI Pharmaceutical Management
Branch (PMB) for review and agrees to reasonable labeling revisions to comply with ICD label guidelines, which guidelines shall be provided to Collaborator sufficiently in advance. NCI NSC (National Service Center) numbers provided by ICD will be
required to be on the label of Investigational Agent for all ICD-sponsored clinical trials. Collaborator will provide a Certificate of Analysis to ICD for each lot of the finished Test Article
provided. 

 Amend Article 3.9 to read as follows: 

 

	3.9	Test Article Delivery and Usage. Collaborator will ship the Test Article and, if required, Placebo to ICD in containers marked in accordance with 21 C.F.R. §
312.6. ICD agrees that the ICD Clinical Investigators will keep appropriate records and take reasonable steps to ensure that the Test Article is used in accordance with the Protocol(s) and applicable FDA regulations. In addition, ICD agrees
that the Test Article (and all Confidential Information supplied by Collaborator relating to the Test Article) will be used solely for the conduct of the CRADA research and development activities. Furthermore, ICD agrees that no analysis or
modification of the Test Article will be performed without Collaborator’s prior written consent. At the completion of the Research Plan, any unused quantity of Test Article will be returned to Collaborator or disposed as directed by
Collaborator at Collaborator’s expense. Pharmacy contacts at ICD will be determined by ICD and communicated to Collaborator. The contact person for ICD will be Mr. Charles Hall, Chief, Pharmaceutical Management
Branch (Telephone Number 301-496-5725) and the Collaborator contact will be Ms. Aline Oliver (Telephone Number: 303-625-2745), if Ms. Oliver is not reasonably available, then the contact will be John Frenz, Vice President of Operations (Telephone Number: 303-625-2880), or such other person designated by Collaborator in writing. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 Amend Article 3.10 to read as follows: 

 

	3.10	Monitoring. 

  

	 	3.10.1	ICD will be responsible for monitoring the conduct of the Protocol(s) and for assuring the quality of all clinical data, unless otherwise stated in the
Research Plan. Monitoring will be performed in accordance with the ICD guidelines as described on the following website: http://ctep.cancer.gov/monitoring/index.html. 

 

	 	3.10.2	Subject to the restrictions in Article 8 concerning IPI, and with reasonable advance notice and at reasonable times, ICD will permit Collaborator or its
designee(s) access to ICD clinical site to monitor the conduct of the research,. Collaborator may also make arrangements with ICD as well as to audit source documents containing Raw Data, at
Collaborator’s expense, to the extent necessary to verify compliance with FDA Good Clinical Practice (International Conference on Harmonisation (ICH) E6: “Good Clinical Practice: Consolidated Guidance; 62 Federal Register 25,
691 (1997)) and the Protocol(s). With reasonable advance notice and at reasonable times, ICD will also permit Collaborator or its designee(s) to review and audit CRADA Data, at Collaborator’s expense, to the extent necessary to
support an NDA (New Drug Application) filing with FDA.  

 Amend Article 3.11 to read as follows: 

 

	3.11	FDA Meetings/Communications. All formal meetings with the FDA concerning any clinical trial studies to be conducted within the
scope of the Research Plan will be discussed by Collaborator and ICD in advance. Each Party reserves the right to take part in setting the agenda for, to attend, and to participate in these meetings. ICD will provide Collaborator with copies of
all FDA meeting minutes, all transmittal letters for IND submissions, IND safety reports, formal questions and responses that have been submitted to the FDA, Annual Reports, and official FDA correspondence, pertaining either
to the INDs under this CRADA or to the Clinical Investigators on Protocols performed in accordance with the Research Plan, except to the extent that those documents contain the proprietary information of a third party (provided that, to the
extent reasonably practicable, ICD will redact such third party proprietary information and provide such redacted documents to Collaborator) or dissemination is prohibited by applicable law. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 Add the following Article 3.12: 

 

	3.12	Regulatory Inspections. Each Party shall promptly notify the other Party of any FDA or other regulatory inspections of its facilities or operations relating
to the Study of which it becomes aware relating to Test Article. Collaborator and ICD shall each have the opportunity to receive a copy of any response to FDA relating to such inspection.  

Add the following Article 3.13: 
  

	3.13	Visits and Review by Collaborator. Collaborator or Collaborator’s representatives may visit and/or meet with ICD employees (including but not limited to
the ICD PI) and examine the site at ICD where the clinical studies will be conducted upon reasonable advance notice and during normal business hours to observe the progress of the studies and review all documents, data, information, and materials
relating to the studies. ICD shall assist Collaborator in scheduling such visits.  

 Amend Article 4.1 to read as
follows: 
  

	4.1	Interim Research and Development Reports. The CRADA PIs should exchange information regularly, in writing will exchange information and
interim progress reports regularly, in writing, on a schedule to be agreed upon by the Parties. This exchange may be accomplished through meeting minutes, detailed correspondence, circulation of draft manuscripts, Steering Committee
reports, copies of Annual Reports and any other reports updating the progress of the CRADA research. However, the Parties must exchange updated Investigator’s Brochure, formulation and preclinical data, and toxicology findings, as they
become available. 

 Amend Article 4.4 to read as follows: 

 

	4.4	Safety Reports. In accordance with FDA requirements ICD, as the IND Sponsor, will establish and maintain records and submit safety reports to the FDA, as
required by 21 C.F.R. § 312.32 and 21 C.F.R. 812.150(b)(1), or other applicable regulations. In the conduct of research under this CRADA, the Parties will comply with specific ICD guidelines and policies for reporting ADEs and AEs, as well as
procedures specified in the Protocol(s). ICD must provide Collaborator with copies of all Safety Reports concurrently with their submission to the FDA, and with any other information affecting the safety of Human Subjects in research conducted under
this CRADA. ICD shall report all Serious and/or Unexpected Adverse Events to FDA in accordance with the reporting obligations of 21 CFR 312.32. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

	 	4.4.1	Within 24 to 48 hours of notification to FDA of any SAE related to Test Article affecting the safety of Human Subjects in clinical studies conducted under this CRADA
that requires expedited reporting to the FDA (either a 7-day or 15-day report), ICD will notify Collaborator’s Chief Medical Officer or such other Collaborator
designee and provide all related reports to Collaborator. All other Adverse Event reports received by ICD shall be reported to the FDA consistent with 21 CFR 312.32 and 312.33. 

 

	 	4.4.2	Within 24 to 48 hours of notification to FDA of any SAE affecting the safety of Human Subjects in clinical studies for Tarmogens within or outside the scope of this
CRADA that requires expedited reporting to the FDA (either a 7-day or 15-day report), Collaborator or its designee will notify and provide all related reports to
ICD. 

  

	 	4.4.3	When feasible, Parties will notify each other of any SAE covered by sections 4.4.1 or 4.4.2 in advance of notifying FDA. In the event that Collaborator
informs the FDA of any Serious and/or Unexpected Adverse Events, Collaborator must notify ICD at the same time by sending the reports to CTEPSupportAE@tech-res.com. ICD will then notify the Clinical Investigator(s) conducting studies under ICD-sponsored protocols, if appropriate. 

 Amend Article 4.5 to read as follows:

  

	4.5	Annual Reports. ICD will provide Collaborator a copy of the Annual Report concurrently with the submission of the Annual Report to the FDA. Annual Reports will
be kept confidential in accordance with Article 8. Collaborator will provide ICD with a copy of its Annual Report to the FDA if Collaborator is sponsoring studies of Investigational Agent under its own IND.  

Amend Article 5.4 to read as follows: 
  

	5.4	Capital Equipment. Collaborator’s commitment, if any, to provide ICD with capital equipment to enable the research and development activities under the
Research Plan appears in Appendix B. If Collaborator transfers to ICD the capital equipment or provides funds for ICD to purchase it, then ICD will own the equipment. If Collaborator loans capital equipment to ICD for use during the CRADA,
Collaborator will be responsible for paying all costs and fees associated with the transport, installation, maintenance, repair, removal, or disposal of the equipment, and ICD will not be liable for any damage to the equipment, except to the
extent due to the negligence or willful misconduct of ICD employees or to the material breach of this Agreement by ICD.  

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 Amend Article 6.1 to read as follows: 

 

	6.1	Ownership of CRADA Subject Inventions, CRADA Data, and CRADA Materials. Subject to the Government license described in Paragraph 7.5, the sharing requirements of
Paragraph 8.1 and the regulatory filing requirements of Paragraph 8.2, the producing Party will retain sole ownership of and title to all CRADA Subject Inventions, all copies of CRADA Data, invented solely by its employees,
and all CRADA Materials produced solely by its employee(s). The Parties will own jointly all CRADA Subject Inventions invented jointly and all CRADA Materials developed jointly. The Parties will own jointly all CRADA Data, with no obligation to
account for each Party’s use of CRADA Data, regardless of authorship subject to Article 8.2.1.  

 Amend Article
6.3 to read as follows: 
  

	6.3	Filing of Patent Applications. Each Party will make timely decisions regarding the be responsible for filing of Patent Applications
on the CRADA for its own Subject Inventions made solely by its employee(s), in a timely manner and at its own expense, and will notify promptly inform the other Party in advance
of any such filing. Collaborator will have the first opportunity to file a Patent Application on joint CRADA Subject Inventions and will notify PHS of its decision within sixty ninety (6 90)
days of an Invention being reported or at least thirty sixty (3 60) days before any patent filing deadline, whichever occurs sooner. If Collaborator fails to notify PHS of its decision within that time
period or notifies PHS of its decision not to file a Patent Application, then, after providing Collaborator prior written notice of its intentions, PHS has the right to file a Patent Application on the joint CRADA Subject Invention. Neither
Party will be obligated to file a Patent Application. Collaborator will place the following statement in any Patent Application it files on a CRADA Subject Invention: “This invention was created in the performance of a Cooperative Research and
Development Agreement with the National Institutes of Health, an Agency of the Department of Health and Human Services. The Government of the United States has certain rights in this invention.” If either Party files a Patent Application on a
joint CRADA Subject Invention, then the filing Party will include a statement within the Patent Application that clearly identifies the Parties and states that the joint CRADA Subject Invention was made under this CRADA. 

Amend Article 6.5 to read as follows: 
  

	6.5	Prosecution of Patent Applications. The Party filing a Patent Application will provide the non-filing Party with a copy
of any official communication relating to prosecution of the Patent Application within thirty (30) days of transmission of the communication. Each Party will also provide the other Party with the power to inspect and make copies of all
documents retained in the applicable Patent Application or Patent file. The Parties agree to consult with each other regarding the prosecution of Patent Applications directed to joint CRADA Subject Inventions. If Collaborator elects to file
and prosecute Patent Applications on The  

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 prosecuting Party with respect to any joint CRADA Subject Inventions then
Collaborator agrees to will use the U.S.P.T.O. Customer Number Practice and/or grant PHS a the nonprosecuting Party associate power(s) of attorney (or its equivalent) as necessary to
assure PHS adequately protect the nonprosecuting Party’s access to its intellectual property rights in these such Patent Applications. PHS and Collaborator will cooperate with each other to obtain
necessary signatures on Patent Applications, assignments, or other documents. If licensing is contemplated by Collaborator, the Parties will consult each other with respect to the prosecution of Patent Applications for such CRADA Subject
Inventions solely owned by ICD pursuant to this CRADA.  
 Amend Article 7.2 to read as follows: 

 

	7.2	Collaborator’s License Option to CRADA Subject Inventions. With respect to any CRADA Subject Invention made solely by an ICD employee, PHS hereby grants
to Collaborator an irrevocable, perpetual, paid-up, nonexclusive, nontransferable, royalty-free, world-wide license, for internal research and development purposes only. With respect to Government rights to any CRADA Subject Invention made
solely by an ICD employee(s) or made jointly by an ICD employee(s) and a Collaborator employee(s), agent(s), or contractor(s) for which a Patent Application was filed, PHS hereby grants to Collaborator an exclusive option to elect an
exclusive or nonexclusive commercialization license. The license will be substantially in the form of the appropriate model PHS license agreement and will fairly reflect the nature of the CRADA Subject Invention, the relative contributions of the
Parties to the CRADA Subject Invention and the CRADA, a plan for the development and marketing of the CRADA Subject Invention, the risks incurred by Collaborator, and the costs of subsequent research and development needed to bring the CRADA Subject
Invention to the marketplace. The field of use of the license will not exceed the scope of the Research Plan. [*]. Each Party shall take and shall require its applicable employees to take such actions as deemed reasonably
necessary by the owning Party, at such Party’s request and expense, including without limitation, executing all necessary documents to affect the allocation of ownership described herein. Should ICD anticipate the need to involve contractors to
fulfill its obligations under this CRADA, ICD shall so notify Collaborator in advance. Upon mutual consent of the Parties and should the research be supportive of further clinical studies which will require the involvement of extramural clinical
sites managed by CTEP, the Parties agree to amend this CRADA. Such amendment will contain provisions noting that CTEP shall ensure in any such Funding Agreement that CTEP will include provisions granting Collaborator those rights described in
CTEP’s Intellectual Property Option to Collaborators in each Funding Agreement with an extramural clinical site. For purposes of this Paragraph 7.2, a “Funding Agreement” shall be defined as a contract, grant or cooperative agreement
entered into between a Federal agency and another party for the performance of experimental, developmental or research work funded in whole or in part by the Federal Government. However, ICD’s contractors or grantees are not parties to the
CRADA and this CRADA does not grant to Collaborator any rights to Inventions made by ICD’s contractors or grantees. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 Amend Article 7.3 to read as follows: 

 

	7.3	Exercise of Collaborator’s License Option. To exercise the option of Paragraph 7.2 Collaborator must submit a written notice to the PHS Patenting and
Licensing Contact identified on the Contacts Information Page (and provide a copy to the ICD Contact for CRADA Notices) within three (3) months after either (i) Collaborator receives written notice from PHS that the Patent Application has
been filed or (ii) the date on which Collaborator files the Patent Application. The written notice exercising this option will include a completed “Application for License to Public Health Service Inventions,” which will be made
available to Collaborator and will initiate a negotiation period that expires [*] after the exercise of the option. If PHS has not responded in writing to the last proposal by Collaborator within this [*] period, the negotiation period will be
extended to expire [*] after PHS so responds, during which [*] period Collaborator may accept in writing the final license proposal of PHS. [*]. These time periods may be extended at the sole discretion of PHS upon good cause shown in
writing by Collaborator. 

 Amend Article 8.2 to read as follows: 

 

	8.2	Use of CRADA Data and CRADA Materials. The Parties will be free to utilize CRADA Data and CRADA Materials internally for their own purposes, consistent with their
obligations under this CRADA. The Parties may share CRADA Data or CRADA Materials or any other Confidential Information disclosed by the other Party under this CRADA with their Affiliates, employees, agents or contractors provided the obligations of
(and with respect to Collaborator with its investors and/or partners) provided such persons and entities have a need to know and are bound by obligations no less restrictive than those set forth in this Article 8.2. are simultaneously conveyed.

  

	 	8.2.1	CRADA Data. Collaborator and ICD will use reasonable efforts to keep CRADA Data confidential until published or until corresponding Patent Applications are
filed. To the extent permitted by law, each Party will have the right to use any and all CRADA Data in and for any regulatory filing by or on behalf of the Party. 

 

	 	8.2.2	CRADA Materials. Collaborator and ICD will use reasonable efforts to keep descriptions of CRADA Materials confidential until published or until corresponding
Patent Applications are filed. Collaborator acknowledges that the basic research mission of PHS includes sharing with third parties for further 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 research those research resources made in whole or in part with NIH funding. Consistent
with this mission and the tenets articulated in “Sharing of Biomedical Research Resources: Principles and Guidelines for Recipients of NIH Research Grants and Contracts”, December 1999, available at
http://ott.od.nih.gov/NewPages/RTguide_final.html, following publication either Party may make available to third parties for further research those CRADA Materials made jointly by both PHS and Collaborator. Notwithstanding the above, if those joint
CRADA Materials are the subject of a pending Patent Application or a Patent, or were created using a patent pending or patented material or technology, the Parties may agree to restrict distribution or freely distribute them.
contain or comprise Tarmogens any transfer, distribution or disclosure of such materials by ICD to third parties requires the prior written consent of Collaborator. If such joint CRADA Materials contain or comprise ICD Materials, any transfer,
distribution or disclosure of such materials by Collaborator to third parties requires the prior written consent of ICD. Either Party may distribute those CRADA Materials made solely by the other Party only upon written consent from that other
Party or that other Party’s designee. 
 Amend Article 8.3 to read as follows: 

 

	8.3	Confidential Information. Each Party agrees to limit its disclosure of Confidential Information to the amount necessary to carry out the Research Plan, and will
place a confidentiality notice on all this of its Confidential iInformation disclosed to the other Party. A Party orally disclosing Confidential Information to the other Party will summarize the
disclosure in writing and provide it to the other Party within fifteen thirty (15 30) days of the disclosure. Each Party receiving Confidential Information agrees to use it only for the purposes
described in the Research Plan. Either Party may object to the designation of information as Confidential Information by the other Party; provided that such Party can demonstrate by competent written evidence that such information was not
properly designated as Confidential Information. 

 Amend Article 8.5 to read as follows: 

 

	8.5	Human Subject Protection. The research to be conducted under this CRADA involves Human Subjects or human tissues within the meaning of 45 C.F.R. Part 46, and all
research to be performed under this CRADA will conform to applicable federal laws and regulations. Additional information is available from the HHS Office for Human Research Protections (http://www.hhs.gov/ohrp/). The confidentiality of
IPI of subjects enrolled in studies at NIH facilities is protected pursuant to the Privacy Act (5 U.S.C. 552a, implementing regulations 45 CFR Part 5b). Any disclosure to Collaborator will be done in accordance with applicable law and regulations.
ICD will provide a copy of the informed consent template to Collaborator for its records. All informed consent forms used in clinical studies conducted under this CRADA must identify the existence of Collaborator and Collaborator’s right to
access and use IPI contained in the Raw Data as provided in Paragraph 3.10.2 above. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 Amend Article 8.6 to read as follows: 

 

	8.6	Duration of Confidentiality Obligation. The obligation to maintain the confidentiality of Confidential Information will expire at the earlier of the date when
the information is no longer Confidential Information as defined in the definition of “Confidential Information” under Article 2 or [*] after the expiration or termination date of this CRADA, except for IPI, for which the obligation
to maintain confidentiality will extend indefinitely. Collaborator may request an extension to this term when necessary to protect Confidential Information relating to products not yet commercialized, which approval will not unreasonably be
withheld, to the extent permitted by law. 

 Amend Article 8.7 to read as follows: 

 

	8.7	Publication. The Parties are-encouraged agree and acknowledge that compliance with the terms of this
paragraph 8.7 is essential to maintaining the integrity of the research conducted under this CRADA and further research, development, and commercialization of products based on or incorporating the Test Article. Subject to the terms and conditions
of this Agreement, the Parties are encouraged to make and shall have the right to make publicly available the results of their research and development activities hereunder. Before either Party submits a paper or abstract for publication
or otherwise intends to publicly disclose information about a CRADA Subject Invention, CRADA Data, or CRADA Materials, the other Party will have thirty (30) days to review proposed manuscripts publications and
three seven (3 7) days to review proposed abstracts of any presentation to assure that Confidential Information is protected, to file Patent Applications on subject matter contained therein,
or to ensure the accuracy of the information. Either Party may request in writing that the proposed publication or other disclosure be delayed for up to thirty six (3 60) additional days as
necessary to file a Patent Application. 

 Amend Article 9.1 to read as follows: 

 

	Article 9.	Representations and Warranties 

  

	9.1	Representations of ICD. ICD hereby represents to Collaborator that: 

 

	 	9.1.1	ICD has the requisite power and authority to enter into this CRADA and to perform according to its terms, and that ICD’s official signing this CRADA has authority
to do-so execute on behalf of and to bind ICD. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

	 	9.1.2	To the best of its knowledge and belief, neither ICD nor any of its personnel involved in this CRADA is presently subject to debarment or suspension by any agency of
the Government which would directly affect its performance of the CRADA. Should ICD or any of its personnel involved in this CRADA be debarred or suspended during the term of this CRADA, ICD will notify Collaborator within thirty (30) days of
receipt of final notice. 

 Amend Article 9.2 to read as follows: 

 

	9.2	Representations and Warranties of Collaborator. Collaborator hereby represents and warrants to ICD that: 

 

	 	9.2.1	Collaborator has the requisite power and authority to enter into this CRADA and to perform according to its terms, and that Collaborator’s official signing this
CRADA has authority to do so. 

  

	 	9.2.2	Neither Collaborator nor, to the best of Collaborator’s knowledge and belief, any of its personnel involved in this CRADA, including Affiliates, agents, and
contractors are presently subject to debarment or suspension by any agency of the Government. Should Collaborator or any of its personnel involved in this CRADA be debarred or suspended during the term of this CRADA, Collaborator will notify ICD
within thirty (30) days of receipt of final notice. 

  

	 	9.2.3	Subject to Paragraph 12.3, and if and to the extent Collaborator has agreed to provide funding under Appendix B, Collaborator is financially able to satisfy these
obligations in a timely manner. 

  

	 	9.2.4	As of the date of delivery to ICD, Tthe Test Article provided has been produced by Collaborator to ICD hereunder for
the conduct of clinical studies under this CRADA has been manufactured in accordance with the FDA’s current Good Manufacturing Practice set out in 21 C.F.R. §§ 210-211 and ICH QA7, and meets
the specifications cited in the Certificate of Analysis and Investigator’s Brochure provided to ICD. 

Amend Article 10.2 to read as follows: 
  

	10.2	Termination by Mutual Consent. ICD and Collaborator may terminate this CRADA at any time by mutual written consent. In such event, the Parties shall specify
the disposition of all property, CRADA Data, CRADA Subject Inventions, CRADA Materials, or Patent Applications and other work accomplished or in progress arising from or performed under this CRADA, all in accordance with the rights granted to the
Parties under the terms of this CRADA, to the extent reasonably practical.  

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 Amend Article 10.6 to read as follows: 

 

	10.6	Supply if Collaborator Failure-to Terminates or Fails to Continue Development. If
Collaborator terminates this CRADA or otherwise suspends development of the Test Article during the term of this CRADA in connection with any ongoing clinical study without the transfer of its active development efforts, assets, and
obligations to a third party within ninety (90) days of discontinuation, Collaborator agrees that ICD may it shall continue developing the Test Article. In that event, the following will apply: to
provide the Test Article (and Placebo, if applicable) with respect to all patients to be enrolled under any protocol(s) approved or active as of the effective date of termination of development; provided, however, that Collaborator will not be
responsible to provide any Test Article to the extent that such action would pose a legitimate concern regarding the health or safety of such Human Subjects or such action would be prohibited by applicable law or regulation, the FDA, or the
applicable IRB. Nothing contained in this Paragraph 10.6 shall be construed to obligate Collaborator to supply the Test Article after the applicable clinical study has been completed. In addition, in the event that a receiver is appointed for
Collaborator, or Collaborator makes a general assignment for the benefit of its creditors; commences, or has commenced against it, proceedings under the United States bankruptcy code, which proceedings are not dismissed within sixty (60) days;
or is liquidating, dissolving or ceasing business operations (each, an “Insolvency Event”), Collaborator hereby grants and agrees to grant ICD a nonexclusive, paid up license to manufacture and use the Test Article for the ICD’ s
study or studies being completed under this Article. 

  

	 	10.6.1	Collaborator agrees to transfer to ICD all information necessary to enable abandoned for reasons relating to safety as determined by the data safety monitoring
board, to provide the Test Article (and Placebo, if any) in Collaborator’s inventory to ICD. 

  

	 	10.6.2	Further, Collaborator hereby grants to ICD a nonexclusive, irrevocable, world wide, paid up license to practice, or have practiced for or on behalf 4-the-Government, any Background Invention that Collaborator-may currently have or will obtain on the Test Article, its manufacture, or
on 

 Amend Article 12.2 to read as follows: 

 

	12.2	Indemnification and Liability. Collaborator agrees to hold the United States Government harmless and to indemnify the Government for all liabilities,
demands, damages, expenses and losses resulting from claims brought by third parties against the Government arising out of the use by Collaborator for any purpose of the CRADA Data, CRADA Materials or CRADA Subject Inventions produced in
whole or part by ICD employees under this CRADA, unless due to the negligence or willful misconduct of ICD, its employees, or agents. The Government has no statutory authority to indemnify Collaborator. Each Party otherwise will be liable for any
claims or damages it incurs in connection with this CRADA, except that ICD, as an agency of the Government, assumes liability only to the extent provided under the Federal Tort Claims Act , 28 U.S.C. Chapter 171. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 Amend Article 12.3 to read as follows: 

 

	12.3	Force Majeure. Neither Party will be liable for any unforeseeable event beyond its reasonable control and not caused by its own fault or negligence, which causes
the Party to be unable to perform its obligations under this CRADA, and which it has been unable to overcome by the exercise of due diligence. If a force majeure event occurs, the Party unable to perform will promptly notify the other Party.
It The affected Party will use its best commercially reasonable efforts to resume performance as quickly as possible and will suspend performance only for such period of time as is necessary as a
result of the force majeure event. 

 Amend Article 13.2 to read as follows: 

 

	13.2	Compliance with Law. ICD and Collaborator agree that they will comply with, and advise any contractors, grantees, or agents they have engaged to conduct the
CRADA research and development activities to comply with, all applicable Executive Orders, statutes, and HI-IS regulations relating to research on human subjects (45 C.F.R. Part 46, 21 C.F.R. Parts 50 and 56)
and relating to the appropriate care and use of laboratory animals (7 U.S.C. § 2131 et seq.; 9 C.F.R. Part 1, Subchapter A). ICD and Collaborator will advise any contractors, grantees, or agents they have engaged to conduct clinical
trials for this CRADA that they must comply with all applicable federal regulations for the protection of Human Subjects, which may include the Federal Privacy Act and implementing regulations set forth at 45 CFR Part 5b and the Standards for
Privacy of Individually Identifiable Health Information set forth in 45 C.F.R. Part 164. Collaborator agrees to ensure that its employees, contractors, and agents who might have access to a “select agent or toxin” (as that term is defined
in 42 C.F.R. §§ 73.4-73.5) transferred from ICD is properly licensed to receive the “select agent or toxin”. 

Amend Article 13.10 to read as follows: 
  

	13.10	 Use of Name; Press Releases. By entering into this CRADA, the Government does not directly or indirectly endorse any product or service that is
or will be provided, whether directly or indirectly related to either this CRADA or to any patent or other intellectual-property license or agreement that implements this CRADA by Collaborator, its successors, assignees, or licensees. Collaborator
will not in any way state or imply that the Government or any of its organizational units or employees endorses any product or services. Each Party agrees to provide proposed press releases that reference or rely upon the work under this CRADA to

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

	 	
the other Party for review and comment, to the extent reasonably practicable, at least five (5) business days before publication or release for review and comment
and shall consider such Party’s comments in good faith, provided, that Collaborator’s obligations hereunder are subject to the requirements of any applicable laws and regulations, including all U.S. Securities and Exchange Commission
requirements. Either Party may disclose the Title and Abstract of the CRADA to the public without the approval of the other Party. 

 Amend Article 13.13 to read as follows: 
  

	13.13	Entire Agreement. This CRADA, together with all Appendices attached hereto, constitutes the entire agreement between the Parties concerning the subject
matter of this CRADA and supersedes any prior understanding or written or oral agreement between the Parties relating to the subject matter of this CRADA, including, without limitation the LOI and the corresponding terms of the Model PHS CRADA
referred to in Article 1. 

 Amend Article 13.14 to read as follows: 

 

	13.14	Survivability. The provisions of Paragraphs 3.3, 3.4, 3.8, 4.2, 4.3, 5.3, 5.4, 6.1-9.2, 10.3-10.6, 11.1,
11.2, 12.1-12.3, 13.1-13.3, 13.7, 13.10 and 13.14 will survive the expiration or early termination of this CRADA 

 Add Article
13.15: 
  

	13.15	Equitable Relief. The Parties hereby agree that a breach of the terms and conditions of this CRADA may cause irreparable damage to the other Party for which
recovery of damages could be inadequate, and that such other Party will be entitled to seek timely injunctive relief under this CRADA, as well as such further relief as may be granted by a court of competent jurisdiction.

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

			
	 CONFIDENTIAL
	  	GlobleImmune, Inc.-NCI CRADA # 02264

 PUBLIC HEALTH SERVICE 

COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT

 FOR INTRAMURAL-PHS CLINICAL
RESEARCH 
 APPENDIX D 
 LETTER OF INTENT FOR CRADA #02264 
 (SEE ATTACHED) 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

  
 

 
 July 30, 2007 
 GlobeImmune, Inc. 
 1450 Infinite Dr. 
 Louisville CO 80027 
  

			
	Re:	 	Letter of Intent for a Cooperative Research and Development Agreement (“CRADA”)

 NCI CRADA #2264 

NCI Principal Investigator: Jeffrey Schlom, Ph.D. (NCI, CCR, LTIB) 
 Collaborator Investigator: Alex Franzusoff, Ph.D. 
  

			
	Title:	  	 Preclinical and Clinical Development of Yeast-Based Tarmogens Expressing Tumor-Associated Antigens for Cancer

Immunotherapy

 Dear Dr. Franzusoff: 
 It is my understanding that a cooperative research and development project between the parties referenced below is being considered. Accordingly, until the formal Cooperative Research and Development
Agreement (CRADA) is reviewed by the CRADA Subcommittee and approved by the Director, National Cancer Institute (NCI), this Letter is offered to permit the joint research to commence. However, in the case of human clinical trials which are a part of
the subject CRADA, the parties agree that all such trials which may begin prior to the execution of the formal CRADA shall be preceded by the appropriate regulatory approvals (U.S. Food and Drug Administration IND approval or international
equivalents thereof). 
 It is acknowledged by the parties below that cooperative research pursuant to the Research Plan, attached as Appendix
A, will be conducted informally by the NCI Principal Investigator and Collaborator pending formal approval of the CRADA. It is further acknowledged that patentable inventions may be made by NIH employees and employees of the Collaborator. Pursuant
to its authority under the Federal Technology Transfer Act of 1986, as amended, NCI agrees that should this CRADA be approved, it will have retroactive effect to the date that the last party has executed this Letter for any inventions that may be
made under this Research Plan. NCI further agrees that should this CRADA be approved it will have retroactive effect to the date that the last party has executed this Letter for confidentiality obligations specified in the NIH Model CRADA.

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 The NIH Model CRADA provisions for the protection of proprietary information are incorporated in this
Letter by reference and are considered controlling during the period of informal joint research. These provisions include, but are not limited to Articles 2 and 8.1-8.7. The NIH Model CRADA for Intramural
Clinical Research is attached as Appendix B. Furthermore, this Letter replaces and supersedes: 1. Material Transfer Agreement, NCI Reference #23623, executed between the parties on May 11, 2007; 2. Collaboration Agreement, NCI Reference #23090,
executed between the parties on June 1, 2007; 3. Confidential Disclosure Agreement, NCI Reference #5675, executed between the parties on October 18, 2006; and 4. Collaboration Agreement, NCI Reference #17530, executed between the parties
on August 2, 2005. 
 You understand, however, that this Letter is not a commitment on the part of either party to enter into a CRADA.
Further, this Letter is effective for a term not to exceed six (6) months. The six month term may be extended upon mutual agreement of the parties in successive one (1) month increments, provided the CRADA is under active negotiation and
the collaborative research is continuing. Assuming that the necessary approvals are forthcoming, we look forward to a successful collaboration. 
  

	
	Sincerely,
	
	/s/ Karen Maurey
	 Karen Maurey, M.S.

Director, Technology Transfer Center, NCI

  

									
	AGREED AND ACCEPTED:	 		 	
			
	National Cancer Institute	 		 	GlobeImmune, Inc.
			
	/s/ Anna D. Barker	 		 	/s/ Jeffrey Rona
	 Anna D. Barker, Ph.D.
 Deputy Director
	 		 	 Jeffrey Rona

Chief Business Officer

					
	8/02/07	 		 		 	8/15/07	 	
	Date	 		 		 	Date	 	
					
	Attachments:	 		 		 		 	
					
	Appendix A (Research Plan)	 		 		 		 	

 Appendix B (Model CRADA for Intramural Clinical Research, 2005) 
 Letter of Intent Material Transfer Agreement 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 Letter of Intent for Proposed CRADA #2264 

APPENDIX A: LETTER OF INTENT RESEARCH PLAN 
 Preclinical and Clinical Development of Yeast-Based Tarmogens Expressing 

Tumor-Associated Antigens for Cancer Immunotherapy 
 National Cancer Institute (NCI) Investigator: 
 Dr. Jeffrey Schlom

 GlobeImmune, Inc. (GlobeImmune) Investigator: 
 Dr. Alex Franzusoff 
 The goal of this collaboration is to test the potential therapeutic
benefit of administering GlobeImmune’s proprietary whole recombinant heat-killed yeast used to express one or more antigens, including, without limitation, any derivative or modification thereof (sometimes referred to herein as
“Tarmogens”) harboring tumor antigens for the treatment of cancer in animals and in humans. Yeast delivered tumor antigens activate innate immunity as well as antigen-specific immune responses. The use of yeast-based vaccines has been
shown to be effective for cancer immunotherapy in preclinical animal models. A Phase I trial performed by GlobeImmune demonstrated that administering GI-4000 yeast Tarmogens expressing a mutated Ras gene was
well-tolerated (no drug-related serious adverse events and adverse events confined to self-resolving injection site reactions and mild constitutional symptoms) and was immunogenic in 33 subjects with metastatic colorectal and pancreas cancer. There
are two other clinical studies being performed by GlobeImmune. A randomized, placebo-controlled Phase 2 trial is underway at multiple centers to test GI-4000 mutated
Ras-expressing yeast in combination with adjuvant gemcitabine in subjects with newly resected pancreas cancer. In addition, the GI-5005 yeast Tarmogen expressing two
hepatitis C virus (HCV) proteins is being tested in a randomized, placebo-controlled Phase lb trial in subjects with chronic HCV infection. The interim results from that trial confirm that administration of yeast-based immunotherapeutic products is
well-tolerated and immunogenic for yeast-expressed antigens in humans. The dual contributions to immune activation arise from the inherent “adjuvant-like” properties of yeast combined with direct delivery of the expressed tumor antigen for
processing and presentation to the immune system. 
 A number of preclinical models and vaccine strategies have been
developed in Dr. Schlom’s lab and previously used to investigate the therapeutic benefits of cancer vaccines against cancer. In these approaches, tumor-associated antigens (TAAs) which are primarily expressed in human tumor cells and not
expressed or minimally expressed in normal tissues are employed to generate a tumor-specific immune response that results in tumor destruction. The initiation of an effective T-cell immune response to antigens
requires two signals. The first one is antigen specific via the peptide/major histocompatibility complex, and the second or “costimulatory” signal is required for cytokine production, proliferation, and other aspects of T-cell activation. The use of three costimulatory molecules such as B7.1 ICAM-1 and LFA-3 (TRICOM®) has been shown to act in synergy with several tumor antigens and antigen epitopes to activate T-cells, in recombinant poxvirus delivery and expression systems. These TAAs have included carcinoembryonic antigen (CEA), prostate-specific antigen (PSA), and MUC-1.

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 The initial studies proposed in this Letter of Intent Research Plan. (the “Research Plan”)
involve the preclinical testing of GlobeImmune’s Tarmogens expressing CEA, which is overexpressed in a number of epithelial ductal cancers, including non-small cell lung, gastrointestinal (colorectal,
pancreas), breast, and ovarian cancers. This shall be accomplished by GlobeImmune engineering Tarmogens to optimally express CEA and providing sufficient amounts of the Tarmogens to NCI to enable NCI to perform the necessary immunogenicity studies.
NCI will test the Tarmogens in several animal models, including the CEA transgenic mouse with colon tumor cells transduced with human CEA. In addition, several additional tumor antigens, including Brachyury, [*]are proposed to be engineered into
Tarmogens for preclinical testing. Based upon the results of the preclinical testing, clinical studies will be planned and conducted as mutually agreed upon by the parties in writing. 
 Studies to be conducted by GlobeImmune: 
  

	 	1)	Engineer Tarmogens to express CEA (GI-6200 yeast) and several other target tumor antigens provided by the NCI 

 

	 	2)	[*] 

  

	 	3)	[*] 

  

	 	4)	[*] 

  

	 	5)	[*] 

  

	 	6)	[*] 

  

	 	7)	[*] 

  

	 	8)	[*] 

  

	 	9)	[*] 

 GlobeImmune, Inc. will provide to NCI
Tarmogens and other proprietary materials and proprietary data and information related to the Tarmogens and product yeast characterization (the “GI Materials”) as described herein. The GI Materials shall be considered the confidential
information of GlobeImmune, and GlobeImmune shall retain all right and title in and to any GI Materials made available to NCI under this Research Plan and all intellectual property rights related thereto. 

Studies to be conducted by NCI: 
  

	 	1)	Investigate the immunogenicity of yeast-based CEA vaccines in preclinical animal models, [*]: 

 

	 	A)	[*] 

  

	 	B)	[*] 

  

	 	C)	[*] 

  

	 	D)	[*] 

  

	 	E)	[*] 

  

	 	F)	[*] 

  

	 	G)	[*] 

  

	 	2)	[*]: 

  

	 	A)	[*] 

  

	 	B)	[*] 

  

	 	C)	[*] 

  

	 	3)	[*] 

  

	 	4)	Prepare and submit 1NDs for Tarmogens expressing CEA to the FDA 

  

	 	5)	Conduct Phase 1 and Phase 2 clinical studies of Tarmogens expressing CEA at the [*] 

 NCI will share data obtained from studies 1 through 5 with GlobeImmune, Inc. Clinical studies of recombinant yeast vaccines expressing other antigens will be planned and conducted based upon the results
of preclinical studies and as mutually agreed upon by the parties in writing 
 Joint efforts: 

 

	 	1)	Prepare manuscripts, presentations, and reports 

  

	 	2)	Jointly analyze all data 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 MATERIAL TRANSFER AGREEMENT 

for CRADA Letter of Intent 

This Material Transfer Agreement (“MTA”) has been adopted for use by the National Cancer Institute (“NCI”) for all transfers of
research material (“Research Material”) for research to be performed under a Cooperative Research and Development Agreement (CRADA) Letter of Intent, whether NCI is identified below as its Provider or Recipient. 

Provider: NCI 

Recipient: GlobeImmune, Inc. 
 Proposed CRADA #2264 entitled “Preclinical and Clinical Development of Yeast-Based Tarmogens Expressing Tumor-Associated Antigens for Cancer Immunotherapy” 

1. Provider agrees to transfer to Recipient’s Investigator the following Research Material: 

[*] 
 2. THIS RESEARCH MATERIAL
MAY NOT BE USED IN HUMAN SUBJECTS. The Research Material will only be used for research purposes by Recipient’s investigator in his/her laboratory, for the research project described in the Research Plan of the CRADA Letter of Intent (Appendix
A), under suitable containment conditions. Recipient agrees to comply with all Federal rules and regulations applicable to the Research Plan and the handling of the Research Material. 
 2(a). Was the Research Material collected according to 45 CFR Part 46, “Protection of Human Subjects”? 
  ̈ Yes (Please provide Assurance
Number:                    ) 
  ̈ No 
 x Not Applicable (Research Material not collected from humans) 
 4. In all oral presentations or
written publications concerning the Research Project, Recipient will acknowledge Provider’s contribution of this Research Material unless requested otherwise, 
 5. This Research Material represents a significant investment on the part of Provider and is considered proprietary to Provider. Recipient’s investigator therefore agrees to retain control over this
Research Material and further agrees not to transfer the Research Material to other people not under her or his direct supervision without advance written approval of Provider. Provider reserves the right to distribute the Research Material to
others and to use it for its own purposes. When the Research Project is completed, the Research Material will be disposed of, if directed by Provider. 
 6. This Research Material is provided as a service to the research community. IT IS BEING SUPPLIED TO RECIPIENT WITH NO WARRANTIES, EXPRESS OR IMPLIED, INCLUDING ANY WARRANTY OF MERCHANTABILITY OR FITNESS
FOR A PARTICULAR PURPOSE. Provider makes no representations that the use of the Research Material will not infringe any patent or proprietary rights of third parties. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 7. No indemnification for any loss, claim, damage, or liability is intended or provided by any party
under this agreement. Each party shall be liable for any loss, claim, damage, or liability that said party incurs as a result of its activities under this Agreement, except that NIT-I, as an agency of the
United States, assumes liability only to the extent as provided under the Federal Tort Claims Act, 28 U.S.C. 2671 et seq. 
 8. The term of this
MTA shall be the same as that of the Letter of Intent, including any extensions. Should the CRADA be executed, this agreement shall be superceded by the terms of the CRADA. Should the CRADA not be executed, this agreement shall expire at the same
time as the expiration or termination of the Letter of Intent. 
 9. The undersigned Provider and Recipient expressly certify and affirm that
the contents of any statements made herein are truthful and accurate. 
 10. This MTA shall be construed in accordance with Federal law as
applied by the Federal courts in the District of Columbia. 
 SIGNATURES BEGIN ON NEXT PAGE 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

									
	LOI Material Transfer Agreement	 		 	CRADA #2264
			
	For GlobeImmune, Inc.	 		 	
				
	9 Aug 07	 	 	 		 	/s/ Alex Franzusoff
	Date	 		 		 	 Alex Franzusoff, Ph.D.
 Vice President of Research and Development

				
	15 Aug 07	 		 		 	 /s/ Jeffrey Rona

	Date	 		 		 	 Jeffrey Rona

Chief Business Officer

				
	 GlobeImmune, Inc.
 1450
Infinite Drive
 Louisville, CO 80027
	 		 		 	
			
	 For the National Cancer Institute
	 		 	
				
	 07/31/07
	 		 		 	 /s/ Kathleen Carroll

	 Date
	 		 		 	 Kathleen Carroll, Ph.D., MBA
 Associate Director, Technology Transfer Center

			
	 Provider’s Official and Mailing Address:
	 		 	
			
	 NCI Technology Transfer Center

6120 Executive Blvd., Suite 450
 Rockville, MD 20852
	 		 	

 Any false or misleading statements made, presented, or submitted to the Government, including any relevant omissions,
under this Agreement and during the course of negotiation of this Agreement are subject to all applicable civil and criminal statutes including Federal statutes 31 U.S.C. § 38013812 (civil liability) and 18 U.S.C. § 1001 (criminal
liability including fine(s) and/or imprisonment). 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

			
	CONFIDENTIAL	  	GlobeImmune, Inc.-NCI CRADA # 02264

 PUBLIC HEALTH SERVICE 

COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT

 FOR INTRAMURAL-PHS CLINICAL
RESEARCH 
 APPENDIX E 
 FIRST AMENDMENT, LETTER OF INTENT FOR CRADA #02264 
 (SEE ATTACHED) 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

 FIRST AMENDMENT 

To Letter of Intent for Proposed CRADA #2264 
 Preclinical and Clinical Development of Yeast-Based Tarmogens Expressing Tumor Associated Antigens for Cancer Immunotherapy 
 This first amendment (the “Amendment”) to the Letter of Intent (LOI), which was effective as of August 15, 2007; for a Proposed Cooperative Research and Development Agreement (CRADA) #2264,
entitled “1’ reclittical and Clinical Development of Yeast-Based Tarmogens Expressing Tumor-Associated Antigens for Cancer Immunotherapy” is entered into by and between National Cancer Institute (“NCI”) and GlobeImmune, Inc.
(“Collaborator”) to extend the term of the LOI. These changes are set forth below, and except for these changes, all other provisions of the original LOI remain unaffected and in full force and effect, This Amendment may be executed
simultaneously in two Counterparts, each of which shall be an original but all of which shall constitute one and the same instrument. One original is to remain with the National Cancer institute and the other is to remain with the Collaborator.

 1. The last paragraph of the LOI is deleted in-its entirety and replaced with the following:

 “You understand, however, that this Letter is not a commitment on the part of either party to enter into a CRADA. Further, the term of
this Letter shall commence as of August 15, 2007 and shall continue until August 15, 2008, provided that the term may be extended by mutual written agreement of the parties.” 
 ACCEPTED AND AGREED: 
 For the National Cancer Institute: 

 

									
				
	/s/ Anna D. Barker	 		 	1/23/08	 	 
	 Anna D. Barker

Deputy Director, NCI
	 		 	Date	 	
				
	 /s/ Jeffrey Rona
	 		 	1-16-08	 	
	 Jeffrey Rona
 Chief
Business Officer
	 		 	DateEX-10.12.1

 Exhibit 10.12.1 
 [*] = Certain confidential information contained in this document, marked by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the
Securities Act of 1933, as amended. 
  

			
	CONFIDENTIAL	  	GlobeImmune, Inc.-NCI CRADA #02264

 Amendment # 1 
 Cooperative Research and Development Agreement # 2264 
 “Preclinical
and Clinical Development of GlobeImmune, Inc.’s 
 Proprietary Yeast-Based Tarmogens Expressing Tumor-Associated

 Antigens for Cancer Immunotherapy” 
 The purpose of this amendment is to change certain terms of the above-referenced Cooperative Research and Development Agreement (CRADA). These changes are reflected below, and except for these changes,
all other provisions of the original CRADA remain in full force and effect. Two originals of this amendment are provided for execution; one is to remain with the National Cancer Institute and the other is to remain with the Collaborator. 

 

	1.	The name of the Collaborator Principal Investigator is changed to: 

 David Apelian, M.D., Ph.D., M.B.A., 
 Senior Vice-President Research &
Development and Chief Medical Officer, 
 GlobeImmune, Inc. 

 

	2.	A new Appendix F shall be added to this CRADA as set forth immediately following the signature page to this Amendment #1. 

 

	3.	Additional changes to other portions of the Agreement are shown below, where underlining denotes addition of new text, and strikethrough denotes
deletion of text. 

 Appendix A – Research Plan is changed as follows: 

In the section entitled “Goal of this CRADA”: 
 The principal goal of this CRADA is to evaluate the potential therapeutic benefit of administering GlobeImmune, Inc.’s proprietary whole recombinant heat-killed yeast vaccine (referred to herein as
“Tarmogens” ((Targeted Molecular Immunogens)) expressing NCI-supplied tumor antigens for the treatment and/or prevention of cancer in animals and in humans. Activities under this CRADA will involve
the cooperation and collaboration of LTIB at NCI and the Division of Cancer Treatment and Diagnosis (DCTD) at NCI. 
 The
subject matter of this CRADA including any in vitro and in vivo testing conducted by Dr. Jeffrey Schlom is strictly limited to the development of vaccines that utilize NCI’s proprietary tumor associated
antigens and GlobeImmune, Inc.’s proprietary Tarmogens. 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

			
	CONFIDENTIAL	  	GlobeImmune, Inc.-NCI CRADA #02264

  

 The objectives of this CRADA will be divided into two four
parts: 
 Part I: Preclinical Studies: 
 In vitro studies will be performed to investigate the immunogenicity of Tarmogens expressing NCI’s proprietary tumor-associated antigens (TAAs). These TAAs include Carcinoembryonic Antigen
(CEA), Brachyury, [*], point mutated ras, [*]. These recombinant Tarmogens expressing tumor antigens will be produced and supplied to NCI by GlobeImmune, Inc. 
 In vivo studies will be performed by NCI to test the immunogenicity of mutually selected recombinant Tarmogens in preclinical animal models. The data will be shared with GlobeImmune, Inc.

 Part II: Clinical Studies: 
 NCI and GlobeImmune, Inc. will jointly evaluate all preclinical data and based upon these results, clinical studies will be planned and conducted with the recombinant Tarmogens specified in the applicable
Protocol as mutually agreed upon by the parties. NCI will conduct Phase I and Phase 2 clinical studies of Tarmogens expressing CEA [*]. [*]. 
 Future clinical studies may also be conducted under GlobeImmune sponsored INDs by mutual agreement of the Parties. 
 Part III: [*] 
 Part IV: [*] 

In the section entitled “Work Scope of CRADA,” add the following: 

Part III: [*] 

Part IV: [*] 
 Under the section
entitled “DESCRIPTION OF THE CONTRIBUTIONS AND RESPONSIBILITIES OF THE PARTIES”, “[*]” add: 
 • [*]

 Under the section entitled “DESCRIPTION OF THE CONTRIBUTIONS AND RESPONSIBILITIES OF THE PARTIES”, “[*]” add: 

• [*] 

Signatures begin on the following page. 

  
 2 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

			
	CONFIDENTIAL	  	GlobeImmune, Inc.-NCI CRADA #02264

  

 ACCEPTED AND AGREED TO: 
 For the National Cancer Institute 
  

					
	 /s/ Douglas R. Lowy
	 		 	 8/3/11

	Douglas R. Lowy, M.D.	 		 	Date
	Deputy Director, NCI	 		 	
			
	For Collaborator:	 		 	
			
	 /s/ Timothy C. Rodell
	 		 	8 Aug ‘11
	Timothy C. Rodell, M.D.	 		 	Date
	Chief Executive Officer and President	 		 	

  
 3 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

			
	CONFIDENTIAL	  	GlobeImmune, Inc.-NCI CRADA #02264

  

 APPENDIX F 
 MATERIAL TRANSFER AGREEMENT FOR THIRD PARTIES 
 MATERIAL TRANSFER AGREEMENT

 Provider: The U.S. Department of Health and Human Services, as represented by National Cancer Institute, an Institute, Center, or
Division (“ICD”) of the National Institutes of Health 
 Recipient: 
 Provider’s Collaborator: GlobeImmune, Inc., a Delaware corporation having offices at 1450 Infinite Drive, Louisville, Colorado 80027 
 Whereas, the Provider is able to make available to the Recipient certain scientific research materials, developed by Provider and Provider’s Collaborator and in which Provider and/or Provider’s
Collaborator have ownership rights; 
 The Provider and the Recipient agree to the following: 

1. Provider agrees to transfer to Recipient’s Investigator named below the following material owned wholly or in part by Provider’s Collaborator
(such material, the “Research Material”): 
 2. THIS RESEARCH MATERIAL MAY NOT BE USED IN HUMAN SUBJECTS. The Research Material will
only be used for internal academic, non-commercial research purposes by Recipient’s investigator in his/her laboratory, for the Research Project (defined below), under suitable containment conditions and
in accordance with the protocol set forth in Section 3. For clarity, the Research Material may not be used by Recipient for any of the following: 
  

	(i)	commercial purposes; 

  

	(ii)	research or other activities sponsored or funded by a commercial or for-profit entity; 

 

	(iii)	in combination with any other material that may be subject to the rights of a third party sponsor or commercial or for-profit
entity; or 

  

	(iv)	a project pursuant to which Recipient or any of its employees or personnel may be obligated to grant rights to any third party sponsor or commercial or for-profit entity. 

  
 4 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

			
	CONFIDENTIAL	  	GlobeImmune, Inc.-NCI CRADA #02264

  

 Recipient agrees to comply with all Federal rules and regulations applicable to the Research Project and
the handling of the Research Material. Recipient will not modify, reverse engineer, deconstruct, design around or in any way determine or analyze the structure or composition of the Research Material, or generate analogs, derivatives or formulations
based on the Research Material. Recipient will maintain reasonable security measures with respect to the Research Materials, which security measures are no less strict than it maintains to protect its own valuable tangible property against loss,
theft or destruction. 
 3. This Research Material will be used by Recipient’s investigator solely for the performance of the research
protocol (“Research Project”) described with specificity on Attachment A. 
 4. Recipient agrees to treat in confidence, during the
term of this Material Transfer Agreement and for a period of three (3) years thereafter, any information relating to the Research Material, and any other of Provider’s or Provider’s Collaborator’s written information about the
Research Material except for information that was previously known to Recipient or that is or becomes publicly available or which is disclosed to Recipient without a confidentiality obligation. Provider shall use reasonable efforts to identify any
such disclosures from Provider to Recipient as being CONFIDENTIAL by notice delivered to Recipient within thirty (30) days after the date of the disclosure. 
  

	(a)	Recipient may publish or otherwise publicly disclose the results of the Research Project; provided that, before Recipient submits a written document, including without
limitation a paper or abstract, for publication or otherwise intends to publicly disclose information concerning the Research Project, Recipient shall notify Provider (and Provider shall have the right to disclose any such document to
Provider’s Collaborator), and Provider will have forty-five (45) days to review the proposed disclosure to assure that Provider’s and Provider’s Collaborator’s CONFIDENTIAL information is protected, except when a shortened
time period under court order or the Freedom of Information Act pertains. In all oral presentations or written publications concerning the Research Project, Recipient will acknowledge Provider’s and Provider’s Collaborator’s
contribution of this Research Material unless requested otherwise. 

  

	(b)	At intervals mutually agreed upon by the parties during the Research Project, and upon completion of the Research Project, Recipient shall promptly and fully disclose
to Provider any information, data, results, reports, and conclusions obtained or generated in the course of performing the Research Project. Provider shall have the right to disclose any such information, data, results, reports, and conclusions to
Provider’s Collaborator; provided that, for clarity, such information, data, results, reports, and conclusions shall continue to be subject to Section 4(a). 

 5. As between the parties hereto, Provider and/or Provider’s Collaborator shall retain all right or interest in and to the Research Material, and any method or process on or relating thereto now or
hereafter held by Provider and/or Provider’s Collaborator, and Recipient shall not represent to any person that it is the owner of the Research Material. Other than the limited right to use the Research Material for the Research Project as set

  
 5 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

			
	CONFIDENTIAL	  	GlobeImmune, Inc.-NCI CRADA #02264

  

 
forth in Section 2, nothing in this Material Transfer Agreement shall be construed as conferring or granting any right, license or option to license to Recipient to any of Provider’s or
Provider’s Collaborator’s CONFIDENTIAL information, the Research Material, or any patent or other proprietary rights now or hereafter held by Provider or Provider’s Collaborator. The Research Material represents a significant
investment on the part of Provider and Provider’s Collaborator and is proprietary to Provider and Provider’s Collaborator. Recipient’s investigator therefore agrees to retain control over this Research Material and further agrees not
to transfer the Research Material to any person not under her or his direct supervision without advance written approval of Provider. Any and all such persons conducting the Research Project that are under her or his direct supervision to whom the
Research Materials are transferred shall be (a) under obligations of confidentiality at least as protective as those set forth in this Material Transfer Agreement and (b) required to assign any intellectual property conceived, reduced to
practice, made, and/or developed by such person in connection with such access to the Research Material to Recipient. Provider and Provider’s Collaborator reserve the right to distribute the Research Material to others and to use it for their
own purposes. When the Research Project is completed, the Research Material will be disposed of, if directed by Provider. 
 6. This Research
Material is provided as a service to the research community. IT IS BEING SUPPLIED TO RECIPIENT WITH NO WARRANTIES, EXPRESS OR IMPLIED, INCLUDING ANY WARRANTY OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE. Provider makes no representations
that the use of the Research Material will not infringe any patent or proprietary rights of third parties. 
 7. Recipient shall retain title to
any patent or other intellectual property rights in inventions made by its employees in the course of the Research Project, except as otherwise set forth in the first three sentences of Section 5. Recipient agrees not to claim, infer, or imply
endorsement by the Government of the United States of America (hereinafter referred to as “Government”) of the Research Project, the institution or personnel conducting the Research Project or any resulting product(s). Unless prohibited by
law from doing so, Recipient agrees to hold the Government and Provider’s Collaborator harmless and to indemnify the Government and Provider’s Collaborator for all liabilities, demands, damages, expenses and losses arising out of
Recipient’s use, storage, or handling for any purpose of the Research Material. 
 8. The undersigned Provider and Recipient expressly
certify and affirm that the contents of any statements made herein are truthful and accurate. 
 9. This Material Transfer Agreement shall be
construed in accordance with Federal law as applied by the Federal courts in the District of Columbia. 
  

	10.	The Recipient agrees to notify the Provider and Provider’s Collaborator if any of the following occur: 

 

	 	(a)	The Recipient wishes to use the Research Materials for commercial purposes; and 

 

	 	(b)	The Recipient determines that it will file a patent application describing discoveries made using the Research Materials. 

  
 6 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

			
	CONFIDENTIAL	  	GlobeImmune, Inc.-NCI CRADA #02264

  

 11. This Material Transfer Agreement is effective upon the date of the last signature date below and
will continue for twenty-four (24) months from the effective date, unless terminated by either party upon thirty (30) days prior written notice, or unless extended by mutual written agreement. 

12. Modifications to the terms of this Material Transfer Agreement will be effective only upon execution of a written amendment authorized by both the
Provider and Recipient. This Agreement, including without limitation any attachments hereto, contains the entire understanding and agreement between the parties with respect to the subject matter hereof and supersedes all previous and
contemporaneous communications, proposals, representations and agreements, whether oral or written, relating to the subject matter hereof. 
  

					
	  
	 	  	 	 
	Date	 		 	Recipient’s Investigator and Title
			
	  
	 		 	  

	Date	 		 	Authorized Signature for Recipient and Title
	
	Recipient’s Official and Mailing Address:
			
	  
	 		 	  

	Date	 		 	Provider’s Investigator and Title
			
	  
	 		 	  

	Date	 		 	Authorized Signature for Provider and Title

 Provider’s Official and Mailing Address: 
 Any false or misleading statements made, presented, or submitted to the Government, including any relevant omissions, under this Material Transfer Agreement and during the course of negotiation of this
Material Transfer Agreement are subject to all applicable civil and criminal statutes including Federal statutes 31 U.S.C. §§ 3801-3812 (civil liability) and 18 U.S.C. § 1001 (criminal liability including fine(s) and/or imprisonment).

  
 7 

 [*] = Certain confidential information contained in this document, marked
by brackets, is filed with the Securities and Exchange Commission pursuant to Rule 406 of the Securities Act of 1933, as amended. 
  

			
	CONFIDENTIAL	  	GlobeImmune, Inc.-NCI CRADA #02264

  

 Read and acknowledged by Provider’s Collaborator (which, for clarity, is not a party to this
Material Transfer Agreement, and Provider’s Collaborator grants no rights under this Material Transfer Agreement and PROVIDES NO REPRESENTATIONS OR WARRANTIES WITH RESPECT TO THE RESEARCH MATERIAL OR ANY ACTIVITIES CONDUCTED UNDER THIS MATERIAL
TRANSFER AGREEMENT, EXPRESS OR IMPLIED, INCLUDING WITHOUT LIMITATION ANY WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE, OR NON-INFRINGEMENT OF INTELLECTUAL PROPERTY RIGHTS): 

 

					
	 	 		 	 
	Date	 		 	Authorized Signature for Provider’s Collaborator and Title

  
 8

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