Document:

Exhibit
10.1

 

Execution
Version

 

 

 

 

 

LICENSE
AGREEMENT

 

 

between

 

 

TITAN PHARMACEUTICALS, INC.

 

 

and

 

 

OCULAR THERAPEUTIX, INC.

 

 

Dated as of December 6, 2022

 

 

 

 

 

     

     

    

 

TABLE
OF CONTENTS

 

	 	 	Page
	ARTICLE 1 DEFINITIONS  	 	1
	 	 	 	 
	ARTICLE 2 GRANT OF RIGHTS 	 	8
	 	 	 	 
	 	2.1	 Grants to Ocular	 	8
	 	 	 	 
	 	2.2	 Sublicenses 	 	8
	 	 	 	 
	 	2.3	 Retention of Rights; Limitations Applicable to License Grants	 	9
	 	 	 	 
	ARTICLE 3 DEVELOPMENT, REGULATORY AND COMMERCIALIZATION ACTIVITIES; REPRESENTATIVES  	 	9
	 	 	 	 
	 	3.1 	Commercialization 	 	9
	 	 	 	 
	 	3.2	 Statements and Compliance with Applicable Law	 	10
	 	 	 	 
	 	3.3 	Representatives 	 	10
	 	 	 	 
	ARTICLE 4 PAYMENTS AND RECORDS 	 	10
	 	 	 	 
	 	4.1 	Upfront Payments 	 	10
	 	 	 	 
	 	4.2 	Milestones 	 	10
	 	 	 	 
	 	4.3	 Mode of Payment; Offsets 	 	11
	 	 	 	 
	 	4.4	 Taxes	 	11
	 	 	 	 
	 	4.5	 Interest on Late Payments	 	11
	 	 	 	 
	ARTICLE 5 INTELLECTUAL PROPERTY  	 	12
	 	 	 	 
	 	5.1	 Ownership of Intellectual Property 	 	12
	 	 	 	 
	 	5.2	 Maintenance and Prosecution of Patents 	 	12
	 	 	 	 
	 	5.3 	Enforcement of Patents	 	12
	 	 	 	 
	 	5.4	 Invalidity or Unenforceability Defenses or Actions 	 	13
	 	 	 	 
	 	5.5 	Corporate Names 	 	13
	 	 	 	 
	 	5.6	 Orange Book Listing	 	13

 

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	ARTICLE 6 CONFIDENTIALITY AND NON-DISCLOSURE  	 	14
	 	 	 	 
	 	6.1 	Confidentiality Obligations 	 	14
	 	 	 	 
	 	6.2	 Permitted Disclosures 	 	14
	 	 	 	 
	 	6.3 	Use of Name 	 	15
	 	 	 	 
	 	6.4	 SEC Filings and Other Disclosures 	 	16
	 	 	 	 
	 	6.5	 Public Announcements	 	16
	 	 	 	 
	 	6.6	 Return of Confidential Information	 	16
	 	 	 	 
	ARTICLE 7 REPRESENTATIONS AND WARRANTIES; COVENANTS  	 	17
	 	 	 	 
	 	7.1	 Mutual Representations and Warranties	 	17
	 	 	 	 
	 	7.2 	Additional Representations and Warranties of Titan	 	17
	 	 	 	 
	 	7.3	 Additional Covenants of Titan	 	18
	 	 	 	 
	 	7.4	 Additional Covenants of Ocular 	 	18
	 	 	 	 
	 	7.5	 DISCLAIMER OF WARRANTIES 	 	19
	 	 	 	 	 
	 	7.6	ADDITIONAL WAIVER	 	19
	 	 	 	 	 
	ARTICLE 8 INDEMNITY 	 	19
	 	 	 	 	 
	 	8.1 	Indemnification of Titan 	 	19
	 	 	 	 	 
	 	8.2	 Indemnification of Ocular 	 	20
	 	 	 	 	 
	 	8.3	 Indemnification Procedures 	 	20
	 	 	 	 	 
	 	8.4	 Special, Indirect and Other Losses	 	22
	 	 	 	 	 
	 	8.5	 Insurance	 	22
	 	 	 	 
	ARTICLE 9 TERM AND TERMINATION  	 	22
	 	 	 	 
	 	9.1	 Term and Expiration 	 	22
	 	 	 	 
	 	9.2	 Termination 	 	22
	 	 	 	 
	 	9.3 	Rights in Bankruptcy 	 	23
	 	 	 	 
	 	9.4 	Consequences of Termination 	 	24
	 	 	 	 
	 	9.5 	Remedies 	 	24
	 	 	 	 
	 	9.6 	Accrued Rights; Surviving Obligations 	 	24

 

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	ARTICLE 10 MISCELLANEOUS 	 	24
	 	 	 	 	 
	 	10.1	 Force Majeure	 	24
	 	 	 	 	 
	 	10.2	 Assignment 	 	25
	 	 	 	 	 
	 	10.3 	Severability 	 	25
	 	 	 	 	 
	 	10.4 	Dispute Resolution	 	25
	 	 	 	 	 
	 	10.5 	Governing Law, Jurisdiction and Service	 	26
	 	 	 	 	 
	 	10.6 	Notices 	 	26
	 	 	 	 
	 	10.7	 Entire Agreement; Amendments 	 	27
	 	 	 	 	 
	 	10.8 	Equitable Relief 	 	27
	 	 	 	 	 
	 	10.9 	Waiver and Non-Exclusion of Remedies 	 	28
	 	 	 	 	 
	 	10.10 	No Benefit to Third Parties 	 	28
	 	 	 	 	 
	 	10.11	 Further Assurance 	 	28
	 	 	 	 	 
	 	10.12	 Relationship of the Parties 	 	28
	 	 	 	 	 
	 	10.13	 References	 	28
	 	 	 	 	 
	 	10.14	 Construction 	 	29
	 	 	 	 	 
	 	10.15	 Counterparts 	 	29

 

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SCHEDULES

 

Schedule
1.52 – Patent Applications

Schedule 7.2.3 – Patent Application Claims

 

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LICENSE
AGREEMENT

 

This
License Agreement (the “Agreement”) is made and entered into, effective as of December 6, 2022 (the “Effective
Date”), by and between Titan Pharmaceuticals, Inc., a Delaware corporation, having its principal place of business at
400 Oyster Point Blvd., Suite 500, South San Francisco, CA 94080 (“Titan”) and Ocular Therapeutix, Inc., a
Delaware corporation, having its principal place of business at 24 Crosby Drive, Bedford, MA 01730 (“Ocular”).
Titan and Ocular are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

 

Recitals

 

WHEREAS,
Titan owns and controls certain Patent Applications (as defined herein) and will own the Continuing Application (as defined herein)
in the Licensed Territory (as defined herein); and

 

WHEREAS,
Titan wishes to grant an exclusive (even as to Titan), perpetual, fully paid-up license to Ocular and Ocular wishes to take an exclusive
(even as to Titan) license under such Continuing Application, including, without limitation, to have the capability to register, make,
have made, use, offer for sale and sell, import, export and otherwise commercialize ophthalmic products utilizing the Licensed Patents
in the Licensed Territory (as defined herein) in the Field of Use (as defined herein) and Titan wishes to grant Ocular a right of priority
to the Patent Applications, in each case in accordance with the terms and conditions set forth below.

 

NOW,
THEREFORE, in consideration of the premises and the mutual promises and conditions set forth herein and other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, the Parties, intending to be legally bound, do hereby agree as follows:

 

ARTICLE
1

DEFINITIONS

 

Unless
otherwise specifically provided herein, the following terms shall have the following meanings:

 

1.1
“Affiliate” means, with respect to a Party, any Person that controls, is controlled by, or is under common control
with that Party. For the purpose of this definition, “control” shall mean direct or indirect ownership of more than
fifty percent (50%) of the shares of stock entitled to vote for the election of directors, in the case of a corporation, or more
than fifty percent (50%) of the equity interest in the case of any other type of legal entity, status as a general partner in any
partnership, or any other arrangement whereby the entity or person controls or has the right to control the board of directors or
equivalent governing body of a corporation or other entity, or the ability to cause the direction of the management or policies of a
corporation or other entity.

 

1.2 “Agreement” has the meaning set forth in the preamble hereto.

 

    1

     

    

 

1.3
“Anti-Corruption Laws” means the U.S. Foreign Corrupt Practices Act, as amended, and any other applicable
anti-corruption laws and laws for the prevention of fraud, racketeering, money laundering or terrorism.

 

1.4
“Applicable Law” means applicable laws, rules and regulations, including any rules, regulations, guidelines or other
requirements of any Regulatory Authority that may be in effect from time to time, including the FFDCA and the Anti-Corruption
Laws.

 

1.5
“Breaching Party” has the meaning set forth in Section 9.2.1.

 

1.6
“Business Day” means a day other than a Saturday or Sunday or a day on which banking institutions in New York, New
York, U.S.A. are permitted or required to be closed.

 

1.7
“Calendar Year” means each successive period of twelve (12) calendar months commencing on January 1 and ending on December
31, except that the first Calendar Year of the Term shall commence on the Effective Date and end on December 31 of the year in which
the Effective Date occurs and the last Calendar Year of the Term shall commence on January 1 of the year in which the Term ends and end
on the last day of the Term.

 

1.8
“cGMP” means current good manufacturing practices as set forth in 21 C.F.R. Parts 210 and 211, and comparable
regulatory standards promulgated by any other Regulatory Authority in the Licensed Territory, as applicable, as such standards may
be updated from time to time.

 

1.9
“Commercialization” means any and all activities directed to the preparation for sale of, offering for sale of
or sale of a Licensed Product, including activities related to marketing, promoting, selling, distributing, manufacturing, exporting
and importing such Licensed Product and interacting with Regulatory Authorities regarding any of the foregoing. When used as a
verb, “to Commercialize” and “Commercializing” mean to engage in Commercialization and “Commercialized”
has a corresponding meaning.

 

1.10
“Confidential Information” has the meaning set forth in Section 6.1.

 

1.11
“Continuing Application” means a U.S. Patent Application, to be filed by Ocular on or before December 6, 2022, the patent
application number of which shall be automatically deemed to be included in Schedule 1.52 of this Agreement when designated by the U.S.
Patent and Trademark Office, and any patents that issue from that application, and any applications (e.g., continuations or divisionals)
and patents filed claiming priority to that application.

 

1.12
“Control” means, with respect to any item of Information, Regulatory Documentation, material, Patent or other
Intellectual Property Right, possession of the right, whether directly or indirectly and whether by ownership, license or otherwise
(other than by operation of the license and other grants in Section 2.1), to grant a license, sublicense or other right (including
the right to reference Regulatory Documentation) to or under such Information, Regulatory Documentation, material, Patent or other
Intellectual Property Right as provided for herein without violating the terms of any agreement with any Third Party.

 

    2

     

    

 

1.13
“Corporate Names” means the Trademarks, names and logos as Titan may designate in writing from time to time, including
any Trademarks used by Titan or its Affiliates for the commercialization of the Licensed Product.

 

1.14
“Development” means all activities related to preclinical and other nonclinical testing, test method development
and stability testing, toxicology, formulation, process development, manufacturing scale-up, qualification and validation, quality
assurance/quality control, clinical studies, including Manufacturing in support thereof, statistical analysis and report writing,
the preparation and submission of Drug Approval Applications, regulatory affairs with respect to the foregoing and all other activities
necessary or reasonably useful or otherwise requested or required by a Regulatory Authority as a condition or in support of obtaining
or maintaining a Regulatory Approval. When used as a verb, “Develop” means to engage in Development.

 

1.15
“Dispute” has the meaning set forth in Section 10.4.

 

1.16
“Dollars” or “$” means United States Dollars.

 

1.17
“Drug Approval” means an approval granted by the appropriate Regulatory Authority to market a Licensed Product
(as the context admits) in the Field of Use in any particular jurisdiction in the Licensed Territory; provided “Drug
Approval” includes any and all marketing authorizations, but excludes any and all Pricing Approvals and Reimbursement
Approvals.

 

1.18
“Drug Approval Application” means a New Drug Application as defined in the FFDCA or any corresponding foreign application
in the Licensed Territory, but excluding any and all applications for Pricing Approvals and Reimbursement Approvals.

 

1.19
“Effective Date” has the meaning set forth in the preamble hereto.

 

1.20
“Exploit” means to research, Develop, Commercialize, register, Manufacture, have Manufactured, hold or keep (whether
for disposal or otherwise), use, have used, offer for sale or sell, export, or transport. “Exploitation” means the
act of Exploiting a compound, product or process.

 

1.21
“FDA” means the United States Food and Drug Administration and any successor agency thereto.

 

1.22
“FFDCA” means the United States Federal Food, Drug, and Cosmetic Act, as amended from time to time, together with any
rules, regulations and requirements promulgated thereunder (including all additions, supplements, extensions and modifications thereto).

 

1.23 “Field of
Use” means all ophthalmic uses in human and nonhuman animals.

 

    3

     

    

 

1.24 “First Commercial
Sale” means, with respect to a Licensed Product in the Licensed Territory, the first sale by Ocular or an Affiliate, or a Sublicensee
or distributor of Ocular or an Affiliate for monetary value for use or consumption by the end user of such Licensed Product in the Licensed
Territory after Drug Approval for such Licensed Product has been obtained in the Licensed Territory. Supply of Licensed Product for clinical
trial purposes or prior to receipt of Regulatory Approval for such Licensed Product, such as so-called “treatment IND supply,”
“named patient supply,” and “compassionate use supply,” shall not be construed as a First Commercial Sale.

 

1.25
“Good Distribution Practices” or “GDP” means the regulatory standards and principles and guidelines
of good distribution practice as in force from time to time relating to the warehousing, storage and physical distribution of medicinal
products established by the relevant Regulatory Authority, including without limitation the guidelines for Good Distribution Practice
as promulgated in “Guidelines of 5 November 2013 on Good Distribution Practice of medicinal products for human use” (2013/C
343/01), as amended from time to time.

 

1.26
“Governmental Authority” means any multi-national, federal, state, local, municipal, provincial or other governmental
authority of any nature (including any governmental division, prefecture, subdivision, department, agency, bureau, branch, office, commission,
council, court or other tribunal).

 

1.27
“Hatch-Waxman Act” means the U.S. “Drug Price Competition and Patent Term Restoration Act” of 1984.

 

1.28
“IIT” has the meaning set forth in Section 6.2.4.

 

1.29
“Improvement” means any invention, discovery, development or modification with respect to a Licensed Product or relating
to the Exploitation thereof, whether or not patented or patentable, including any enhancement in the efficiency, operation, Manufacture,
ingredients, preparation, presentation, formulation, means of delivery or dosage of such Licensed Product, any discovery or development
of any new Indication or expansion of an Indication for such Licensed Product, or any discovery or development that improves the stability,
safety or efficacy of such Licensed Product.

 

1.30
“IND” means (i) an investigational new drug application filed with the FDA, and its equivalent in other regulatory jurisdictions,
for authorization to commence clinical studies and (ii) all supplements and amendments that may be filed with respect to the foregoing.

 

1.31
“Indemnification Claim Notice” has the meaning set forth in Section 8.3.1.

 

1.32
“Indemnified Party” has the meaning set forth in Section 8.3.1.

 

1.33
“Indication” means a primary sickness or medical condition or any interruption, cessation or disorder of a particular
bodily function, system or organ (each a “disease”) requiring a separate Pivotal Registration Clinical Trial
to obtain Regulatory Approval to market and sell a product for such disease.

 

    4

     

    

 

1.34
“Information” means all technical, scientific and other know-how and information, trade secrets, knowledge, technology,
means, methods, processes, practices, formulae, instructions, skills, techniques, procedures, experiences, ideas, technical assistance,
designs, drawings, assembly procedures, computer programs, apparatuses, specifications, data, results and other material, including:
biological, chemical, pharmacological, toxicological, pharmaceutical, physical and analytical, pre-clinical, clinical, safety, manufacturing
and quality control data and information, including study designs and protocols, assays and biological methodology, in each case (whether
or not confidential, proprietary, patented or patentable) in written, electronic or any other form now known or hereafter developed.

 

1.35
“Infringement” has the meaning set forth in Section 5.3.1.

 

1.36
“Insolvency Event” has the meaning set forth in Section 9.2.4.

 

1.37
“Intellectual Property Rights” means all copyrights, trade secrets, Trademarks, Patents, Information and any and all
other intellectual property or proprietary rights now known or hereafter recognized in any jurisdiction.

 

1.38
“Knowledge” means actual knowledge, but without any duty to conduct any investigation with respect to such facts and
information.

 

1.39
“Licensed Patents” means any Patents issued from the Continuing Application, as well as any reissues, reexaminations,
continuations, continuations-in-part (but only to the extent the claims thereof are entirely supported in the specification of the Continuing
Application and entitled to the priority date thereof) or divisionals or corresponding foreign patents or applications thereof, or any
Patents claiming priority to one or more applications to which one or more of the aforesaid Patents claim priority (including continuations-in-part,
but only to the extent the claims thereof are entirely supported in the specification of the Continuing Application and entitled to the
priority date thereof).

 

1.40
“Licensed Product” means any product for use in the Field of Use which, but for the licenses granted to Ocular under
this Agreement, would infringe, or is covered by, one or more Licensed Patents, in any and all forms, presentations, dosages and formulations.

 

1.41
“Licensed Territory” means the United States.

 

1.42
“Losses” has the meaning set forth in Section 8.1.

 

1.43
“Manufacture” and “Manufacturing” means all activities related to the production, manufacture, processing,
filling, finishing, packaging, labeling, shipping and holding of a product or any intermediate thereof, including process development,
process qualification and validation, scale-up, pre-clinical, clinical and commercial manufacture and analytic development, product
characterization, stability testing, quality assurance and quality control.

 

    5

     

    

 

1.44
“Milestones” has the meaning set forth in Section 4.2.1.

 

1.45
“Non-Breaching Party” has the meaning set forth in Section 9.2.1.

 

1.46
“Non-Governmental Authority” means any public body or non-Governmental Authority with the authority to control, approve,
recommend or otherwise determine pricing and reimbursement of pharmaceutical products, including those with authority to enter into risk-sharing
schemes or to impose retroactive price reductions, discounts, or rebates.

 

1.47
“Notice Period” has the meaning set forth in Section 9.2.1.

 

1.48
“Ocular” has the meaning set forth in the preamble hereto.

 

1.49
“Ocular Information and Improvements” has the meaning set forth in Section 5.1.1.

 

1.50
“Orange Book” means the FDA’s Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations.

 

1.51
“Party” and “Parties” have the meaning set forth in the preamble hereto.

 

1.52
“Patent Applications” means the applications listed on Schedule 1.52.

 

1.53
“Patents” means: (i) all national, regional and international patents and patent applications, including provisional
patent applications; (ii) all patent applications filed either from such patents, patent applications or provisional applications or
from an application claiming priority from either of the foregoing, including divisionals, continuations, continuations-in-part, provisionals,
converted provisionals and continued prosecution applications; (iii) any and all patents that have issued or in the future issue from
the foregoing patent applications ((i) and (ii)), including utility models, petty patents, innovation patents and design patents and
certificates of invention; (iv) any and all extensions or restorations by existing or future extension or restoration mechanisms, including
revalidations, reissues, re-examinations and extensions (including any supplementary protection certificates and the like) of the foregoing
patents or patent applications ((i), (ii) and (iii)); and (v) any similar rights, including so-called pipeline protection or any importation,
revalidation, confirmation or introduction patent or registration patent or patent of additions to any of such foregoing patent applications
and patents.

 

1.54
“Payment” has the meaning set forth in Section 4.4.

 

1.55
“Person” means an individual, sole proprietorship, partnership, limited partnership, limited liability partnership, corporation,
limited liability company, business trust, joint stock company, trust, unincorporated association, joint venture or other similar entity
or organization, including a government or political subdivision, department or agency of a government.

 

    6

     

    

 

1.56
“Pricing Approval” means the governmental approval, agreement, determination or decision establishing prices for Licensed
Products (as the context admits) that can be charged in regulatory jurisdictions where the applicable Governmental Authorities approve
or determine the price of pharmaceutical products.

 

1.57
“Regulatory Approval” means (i) Drug Approval and all other approvals necessary for the commercial sale of Licensed Products
in a given country or regulatory jurisdiction; (ii) Pricing Approval (but only in those countries or regulatory jurisdictions where Pricing
Approval is required by Applicable Law for commercial sale); (iii) Reimbursement Approval, but only in those countries or regulatory
jurisdictions where Reimbursement Approval is required for the price paid for Licensed Products to be reimbursed by a Governmental Authority
or a Non-Governmental Authority with the authority to approve reimbursement; (iv) pre- and post-approval marketing authorizations (including
any prerequisite Manufacturing approval or authorization related thereto); and (v) labeling approval.

 

1.58
“Regulatory Authority” means any applicable Governmental Authority or Non-Governmental Authority regulating or otherwise
exercising authority with respect to the Exploitation of Licensed Products or any Improvement thereto in the Licensed Territory, including
the FDA.

 

1.59
“Regulatory Documentation” means: all (i) applications (including all INDs and Drug Approval Applications), registrations,
licenses, authorizations and approvals (including Regulatory Approvals); (ii) correspondence and reports submitted to or received from
Regulatory Authorities (including minutes and official contact reports relating to any communications with any Regulatory Authority)
and all supporting documents with respect thereto, including all adverse event files and complaint files; and (iii) clinical, non-clinical
and other data contained or relied upon in any of the foregoing; in each case ((i), (ii) and (iii)) relating to a Licensed Product, any
Improvement thereto.

 

1.60
“Reimbursement Approval” means the approval, agreement, determination or decision recommending or approving Licensed
Products for use or establishing the prices for Licensed Products that can be reimbursed in regulatory jurisdictions where the applicable
Governmental Authority or Non-Governmental Authority approves, determines or recommends the reimbursement or use of pharmaceutical products.

 

1.61
“Representative(s)” has the meaning set forth in Section 3.3.

 

1.62
“Senior Officer” means, with respect to Titan, its CEO, and, with respect to Ocular, its Chief Executive Officer.

 

    7

     

    

 

1.63
“Sublicensee” means a Person, other than an Affiliate, that is granted a sublicense by Ocular or its Affiliate under
the grants in Section 2.1, as provided in Section 2.2.

 

1.64
“Term” has the meaning set forth in Section 9.1.

 

1.65
“Termination Notice” has the meaning set forth in Section 9.2.1.

 

1.66
“Third Party” means any Person other than Titan, Ocular and their respective Affiliates.

 

1.67
“Third Party Claims” has the meaning set forth in Section 8.1.

 

1.68 “Titan” has the meaning set forth
in the preamble hereto.

 

1.69
“Trademark” means any word, name, symbol, color, shape, designation or any combination thereof, including any trademark,
service mark, trade name, brand name, sub-brand name, trade dress, product configuration rights, program name, delivery form name, certification
mark, collective mark, logo, tagline, slogan, design or business symbol, that functions as an identifier of source, origin or quality,
whether or not registered, and all statutory and common-law rights therein and all registrations and applications therefor, together
with all goodwill associated with, or symbolized by, any of the foregoing.

 

1.70
“United States” or “U.S.” means the United States of America and its territories and possessions
(including the District of Columbia and Puerto Rico).

 

ARTICLE
2

GRANT OF RIGHTS

 

2.1
Grants to Ocular. Subject to Sections 2.2 and 2.3 and the other terms and conditions of this Agreement, Titan hereby grants to
Ocular:

 

2.1.1
an exclusive (even as to Titan) license, with the right to grant sublicenses in accordance with Section 2.2, under the Continuing
Application and any applications filed from the Continuing Application to Exploit a Licensed Product in the Field of Use in the Licensed
Territory (the grant of rights with respect to the Continuing Application will be deemed to have occurred upon the filing of the Continuing
Application with the U.S. Patent and Trademark Office); and

 

2.1.2
a right of priority to the Patent Applications.

 

2.2
Sublicenses. Ocular shall have the right to grant sublicenses, through multiple tiers of Sublicensees, under the licenses
granted in Sections 2.1.1 and 2.1.2, to its Affiliates, Third Parties or any subcontractor; provided that any such
sublicenses shall be consistent with, and expressly made subject to, the terms and conditions of this Agreement. Ocular shall cause
each Sublicensee to comply with the applicable terms and conditions of this Agreement, as if such Sublicensee were a Party to this
Agreement. Ocular hereby (x) guarantees the performance of its Affiliates and permitted Sublicensees that are sublicensed as
permitted herein and the grant of any such sublicense shall not relieve Ocular of its obligations under this Agreement, except to
the extent they are satisfactorily performed by such Sublicensee and (y) waives any requirement that Titan exhaust any right, power
or remedy, or proceed against any Sublicensee for any obligation or performance under this Agreement prior to proceeding directly
against Ocular. A copy of any sublicense agreement executed by Ocular shall be provided to Titan within fourteen (14) days after its
execution; provided that in each case the financial terms of any such sublicense agreement to the extent not pertinent to an
understanding of a Party’s obligations or benefits under this Agreement may be redacted. Ocular shall provide Titan with any
additional materials reasonably requested by Titan in order for Titan to verify that such sublicense is in compliance with the terms
and conditions of this Agreement.

 

    8

     

    

 

2.3
Retention of Rights; Limitations Applicable to License Grants.

 

2.3.1
Retained Rights of Titan. Notwithstanding anything to the contrary in this Agreement and without limitation of any rights granted
to, or reserved by, Titan pursuant to any other term or condition of this Agreement, Titan hereby expressly retains, on behalf of itself
and its Affiliates (and on behalf of its licensors and contractors) all right, title and interest in and to the (i) Licensed Patents,
(ii) Titan’s Corporate Names and (iii) all other Intellectual Property Rights of Titan, in each case, for any and all purposes
of Titan, its Affiliates and its and their contractors, subject only to the rights and licenses granted to Ocular under this Agreement.

 

2.3.2
No Other Rights Granted by Titan. Except as expressly provided in this Agreement, Titan grants no other right or license, express
or implied, including any rights or licenses to any other Patent, Trademark or other Intellectual Property Rights not otherwise expressly
granted herein, whether to Ocular or any other Person, including any Third Party that Manufactures any Licensed Product, and Titan reserves
the right to prosecute any infringement of its Intellectual Property Rights against any such Third Party.

 

ARTICLE
3

DEVELOPMENT, REGULATORY AND COMMERCIALIZATION ACTIVITIES;

REPRESENTATIVES

 

3.1
Commercialization.

 

3.1.1
Diligence. Ocular shall use such efforts as it deems appropriate in its sole discretion to Commercialize a Licensed Product in the
Field of Use throughout the Licensed Territory taking into account, among other factors, the treatment cost, disease incidence and route
of administration.

 

3.1.2
Commercialization Costs. Ocular shall be solely responsible for all costs and expenses in connection with the Commercialization of
a Licensed Product in the Field of Use in the Licensed Territory.

 

3.1.3
Commercialization Records. Ocular shall maintain complete and accurate books and records pertaining to Commercialization of a
Licensed Product hereunder, in sufficient detail to verify compliance with its obligations under this Agreement and which shall be
in compliance with Applicable Law and properly reflect all work done and results achieved in the performance of its
Commercialization activities. Such books and records shall be retained by Ocular for at least three (3) years after the expiration
or termination of this Agreement in its entirety or for such longer period as may be required by Applicable Law. Titan shall have
the right, during normal business hours and upon reasonable notice, at its sole expense, to inspect and copy all such books and
records maintained pursuant to this Section 3.1.3 to verify compliance by Ocular with its obligations under this Agreement; provided that
Titan shall maintain such records and information disclosed therein in confidence in accordance with Article 6.

 

    9

     

    

 

3.2
Statements and Compliance with Applicable Law. Ocular shall, and shall cause its Affiliates and its and their respective
Sublicensees to, comply with all Applicable Law, GDP and cGMP with respect to the Commercialization and Manufacture of a Licensed
Product.

 

3.3
Representatives. As of the Effective Date, each Party shall appoint their most senior executive in charge of intellectual
property matters (a “Representative”) to oversee contact between the Parties for all matters and shall have
such other responsibilities as the Parties may agree in writing after the Effective Date. The Representatives shall work together
to manage and facilitate the communication between the Parties under this Agreement, including the resolution (in accordance with
the terms of this Agreement) of issues between the Parties that arise in connection with this Agreement.

 

ARTICLE
4

PAYMENTS AND RECORDS

 

4.1
Upfront Payments.

 

4.1.1
In partial consideration of the rights granted by Titan to Ocular hereunder, no later than ten (10) days following the Effective
Date, Ocular shall pay to Titan a one-time non-creditable fee of fifty thousand dollars ($50,000.00), which shall be refundable only
if Titan does not maintain the pendency of Patent Application no. 16/338,962 by December 6, 2022.

 

4.1.2
Ocular shall reimburse Titan for up to ten thousand dollars ($10,000.00) for attorneys’ fees incurred by it in connection with
the preparation and negotiation of this Agreement. Ocular shall reimburse Titan no later than thirty (30) days after Titan’s presentation
of an invoice and documentation of such attorney’s fees to Ocular.

 

4.2
Milestones.

 

4.2.1
In partial consideration of the rights granted by Titan to Ocular hereunder, Ocular shall pay to Titan the following payments
within thirty (30) days after the achievement of each of the following milestone events (the “Milestones”),
which payments shall be nonrefundable, non-creditable and fully earned upon the achievement of the applicable milestone event:

 

	No.	 	 	Milestone Event	 	Milestone

Payment	 
	1.	 	 	Issuance of the first Licensed Patent	 	$	35,000	 
	2.	 	 	First Commercial Sale of a Licensed Product	 	$	100,000	 

 

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For
the avoidance of doubt, each Milestone payment shall be payable one time only regardless of the number of Licensed Products that may
be Developed or Commercialized.

 

4.2.2
Determination that Milestones Have Occurred. Ocular shall notify Titan promptly, but in no event later than five (5) Business Days
after Ocular becomes aware of the achievement of each of the events identified as a Milestone in Section 4.2.1. In the event that, notwithstanding
the fact that Ocular has not provided Titan such a notice, Titan believes that any such Milestone has been achieved, it shall so notify
Ocular in writing and the Parties shall promptly meet and discuss in good faith whether such Milestone has been achieved. Any dispute
under this Section 4.2.2 regarding whether or not such a Milestone has been achieved shall be subject to resolution in accordance with
Section 10.4.

 

4.3
Mode of Payment; Offsets. All payments to Titan under this Agreement shall be made by deposit of Dollars in the requisite amount
to such bank account as Titan may from time to time designate by notice to Ocular.

 

4.4
Taxes. The Milestone payments payable by Ocular to Titan pursuant to this Agreement (each, a “Payment”)
shall be paid free and clear of any and all taxes, except for any withholding taxes required by Applicable Law. Except as provided
in this Section 4.4, Titan shall be solely responsible for paying any and all taxes (other than withholding taxes required by
Applicable Law to be deducted from Payments and remitted by Ocular) levied on account of, or measured in whole or in part by reference
to, any Payments it receives. Ocular shall deduct or withhold from the Payments any taxes that it is required by Applicable Law
to deduct or withhold. Notwithstanding the foregoing, if Titan is entitled under any applicable tax treaty to a reduction of rate
of, or the elimination of, applicable withholding tax, it may deliver to Ocular or the appropriate Governmental Authority (with
the assistance of Ocular to the extent that this is reasonably required and is requested in writing) the prescribed forms necessary
to reduce the applicable rate of withholding or to relieve Ocular of its obligation to withhold such tax and Ocular shall apply
the reduced rate of withholding or dispense with withholding, as the case may be; provided that Ocular has received evidence
of Titan’s delivery of all applicable forms (and, if necessary, its receipt of appropriate governmental authorization) at
least fifteen (15) days prior to the time that the Payments are due; provided, further, if Ocular makes a Payment to Titan
without deducting withholding tax and an amount of tax should have been withheld from such Payment, Ocular shall be entitled to
recover the underwithheld tax by an additional withholding from any future Payment to Titan upon the provision to Titan of valid
written notice (in Titan’s sole determination) from a Governmental Authority evidencing that an amount of tax should have
been withheld and is due. If, in accordance with the foregoing, Ocular withholds any amount, it shall pay to Titan the balance
when due, make timely payment to the proper taxing authority of the withheld amount and send to Titan proof of such payment within
ten (10) days following such payment.

 

4.5
Interest on Late Payments. If any payment due to either Party under this Agreement is not paid when due, then such paying Party shall
pay interest thereon (before and after any judgment) at an annual rate (but with interest accruing on a daily basis) of two percent (2%)
above the London Interbank Offered Rate for deposits in Dollars having a maturity of one (1) month published by the Intercontinental
Exchange, as adjusted from time to time on the first London business day of each month, such interest to run from the date on which payment
of such sum became due until payment thereof in full together with such interest.

 

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ARTICLE
5

INTELLECTUAL PROPERTY

 

 5.1 Ownership
of Intellectual Property.

 

5.1.1
Ownership of Technology. As between the Parties, each Party shall own and retain all right, title and interest in and to any
and all: (i) Information, Improvements and other inventions that are conceived, discovered, developed or otherwise made by or
on behalf of such Party or its Affiliates or its or their (sub)licensees (or Sublicensees), as applicable, under or in connection
with this Agreement, whether or not patented or patentable and any and all Patents and other Intellectual Property Rights with
respect thereto (with respect to Ocular, the “Ocular Information and Improvements”); and (ii) other Information,
inventions, Patents and other Intellectual Property Rights that are owned or otherwise controlled (other than pursuant to the
license grants set forth in Section 2.1) by such Party or its Affiliates or its or their (sub)licensees (or Sublicensees) (as
applicable) outside of this Agreement.

 

5.1.2
Ownership of Corporate Names. As between the Parties, Titan shall retain all right, title and interest in and to its Corporate Names.

 

5.2
Maintenance and Prosecution of Patents.

 

5.2.1
In General. As between the Parties, Ocular shall have the sole and exclusive right to prepare, file, prosecute and maintain the Continuing
Application, including any related interference, re-issuance, re-examination and opposition proceedings with respect thereto, in the
Licensed Territory, in each case, at Ocular’s sole cost and expense. Notwithstanding the foregoing, Titan shall cooperate with
Ocular, at Ocular’s expense, to the extent reasonably necessary to prosecute and maintain the Licensed Patents, including by becoming
a party to any proceeding brought by Ocular in connection with such prosecution or maintenance, and executing any necessary documents
such as Power of Attorney forms naming Ocular and/or its intellectual property counsel as attorney-in-fact. Ocular shall have the right
to file one or more terminal disclaimers on behalf of Titan against the Patent Applications.

 

5.3
Enforcement of Patents.

 

5.3.1
Notice. Each Party shall promptly notify the other Party in writing of (i) any alleged or threatened infringement of the Licensed
Patents in any jurisdiction in the Licensed Territory or (ii) any certification filed under the Hatch-Waxman Act claiming that
any Licensed Patents are invalid or unenforceable or claiming that any Licensed Patents would not be infringed by the making,
use, offer for sale, sale or import of a product for which an application under the Hatch-Waxman Act is filed or any equivalent
or similar certification or notice in any other jurisdiction, in each case ((i) and (ii)) of which such Party becomes aware (an
“Infringement”).

 

5.3.2
Enforcement of Patents. As between the Parties, Ocular shall have the sole and exclusive right, but not the obligation, to
prosecute any Infringement with respect to the Licensed Patents, including as a defense or counterclaim in connection with any Third
Party Infringement Claim, at Ocular’s sole cost and expense. Any recovery realized as a result of such litigation described
above in this Section 5.3 (whether by way of settlement or otherwise) shall be retained by Ocular. Notwithstanding the foregoing,
Titan agrees to participate in any enforcement brought by Ocular, at Ocular’s expense, to the extent reasonably necessary to
enforce the Licensed Patents, including by becoming a party to any such enforcement proceeding. Ocular shall have the right to
settle any enforcement action brought by it on such terms as it may determine in its sole discretion, provided that, it may not
agree to any settlement that invalidates or finds the Licensed Patents or the Patent Applications unenforceable without
Titan’s consent which will not be unreasonably withheld or delayed.

 

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5.4
Invalidity or Unenforceability Defenses or Actions. Each Party shall promptly notify the other Party in writing of any alleged or
threatened assertion of invalidity or unenforceability of any of the Licensed Patents by a Third Party, including any declaratory judgment
proceeding, inter partes review, post-grant review or other opposition proceeding with respect thereto, of which such Party becomes
aware. As between the Parties, Ocular shall have the sole and exclusive right, but not the obligation, to defend and control the defense
of the validity and enforceability of the Licensed Patents at its sole cost and expense, including when such invalidity or unenforceability
is raised as a defense or counterclaim in connection with an Infringement action initiated pursuant to Section 5.3. Notwithstanding the
foregoing, Titan agrees to participate in any enforcement brought by Ocular, at Ocular’s expense, to the extent reasonably necessary
to defend the Licensed Patents, including by becoming a party to any such proceeding. Ocular shall have the right to settle any assertion
of invalidity or unenforceability of any of the Licensed Patents brought against it on such terms as it may determine in its sole discretion,
provided that, it may not agree to any settlement that invalidates or finds the Licensed Patents or the Patent Applications unenforceable
without Titan’s consent which will not be unreasonably withheld or delayed.

 

5.5
Corporate Names. Ocular shall not, and shall not permit its Affiliates or its or their Sublicensees to, (i) use in their respective
businesses any Trademarks that are confusingly similar to, misleading or deceptive with respect to or dilute any (or any part) of the
Corporate Names, (ii) do any act that endangers, destroys or similarly affects, in any material respect, the value of the goodwill pertaining
to the Corporate Names or (iii) attack, dispute or contest the validity of or ownership of the Corporate Names anywhere in the Licensed
Territory or any registrations issued or issuing with respect thereto or any pending registration thereof. Ocular agrees, and shall cause
its Affiliates and Sublicensees, to (x) conform to the customary industry standards for the protection of the Trademarks and to such
trademark usage guidelines as Titan may furnish from time to time with respect to the use of the Corporate Names and (y) adhere to and
maintain the highest quality standards of Titan with respect to goods sold and services provided under the Corporate Names.

 

5.6
Orange Book Listing. Ocular may list and Titan will cooperate with regard to the listing of any of the Licensed Patents in connection
with the Regulatory Approval of any Licensed Product in the Orange Book or foreign equivalent.

 

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ARTICLE
6

CONFIDENTIALITY AND NON-DISCLOSURE

 

6.1
Confidentiality Obligations. At all times during the Term and for a period of five (5) years following termination or expiration
hereof in its entirety, each Party shall and shall cause its officers, directors, employees and agents to, keep confidential and
not publish or otherwise disclose to a Third Party and not use, directly or indirectly, for any purpose, any Confidential Information
furnished or otherwise made known to it, directly or indirectly, by the other Party, except to the extent such disclosure or use
is expressly permitted by the terms of this Agreement. “Confidential Information” means any technical, business
or other information provided by or on behalf of one Party to the other Party, including information relating to the terms of
this Agreement (subject to Section 6.4), information relating to any Licensed Product (including the Regulatory Documentation),
any research, Development or Commercialization of any Licensed Product, any Information with respect thereto developed by or on
behalf of the disclosing Party or its Affiliates, or the scientific, regulatory or business affairs or other activities of either
Party. Notwithstanding the foregoing, the terms of this Agreement shall be deemed to be the Confidential Information of both Parties
and both Parties shall be deemed to be the receiving Party and the disclosing Party with respect thereto. Notwithstanding the
foregoing, the confidentiality and non-use obligations under this Section 6.1 with respect to any Confidential Information shall
not include any information that:

 

6.1.1
is or hereafter becomes part of the public domain by public use, publication, general knowledge or the like through no breach of
this Agreement by the receiving Party;

 

6.1.2
can be demonstrated by documentation or other competent proof to have been in the receiving Party’s possession prior to disclosure
by the disclosing Party without any obligation of confidentiality with respect to such information;

 

6.1.3
is subsequently received by the receiving Party from a Third Party who is not bound by any obligation of confidentiality with respect
to such information;

 

6.1.4
has been published by a Third Party or otherwise enters the public domain through no fault of the receiving Party in breach of this
Agreement; or

 

6.1.5
can be demonstrated by documentation or other competent evidence to have been independently developed by or for the receiving Party
without reference to the disclosing Party’s Confidential Information.

 

Specific
aspects or details of Confidential Information shall not be deemed to be within the public domain or in the possession of the receiving
Party merely because the Confidential Information is embraced by more general information in the public domain or in the possession of
the receiving Party. Further, any combination of Confidential Information shall not be considered in the public domain or in the possession
of the receiving Party merely because individual elements of such Confidential Information are in the public domain or in the possession
of the receiving Party unless the combination and its principles are in the public domain or in the possession of the receiving Party.

 

6.2
Permitted Disclosures. Each Party may disclose Confidential Information to the extent that such disclosure is:

 

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6.2.1 made
in response to a valid order of a court of competent jurisdiction or other supra-national, federal, national, regional, state,
provincial and local governmental or regulatory body of competent jurisdiction or, if in the
reasonable opinion of the receiving Party’s legal counsel, such disclosure is otherwise required by law, including by reason
of filing with securities regulators; provided, however, that the receiving Party shall first have given notice to the
disclosing Party and given the disclosing Party a reasonable opportunity to quash such order or to obtain a protective order or
confidential treatment requiring that the Confidential Information and documents that are the subject of such order be held in
confidence by such court or agency or, if disclosed, be used only for the purposes for which the order was issued; and provided,
further, that the Confidential Information disclosed in response to such court or governmental order shall be limited to that
information which is legally required to be disclosed in response to such court or governmental order;

 

6.2.2
made by or on behalf of the receiving Party to the Regulatory Authorities in connection with any filing, application or request for
Regulatory Approval; provided, however, that reasonable measures shall be taken to assure confidential treatment of such information
to the extent practicable and consistent with Applicable Law;

 

6.2.3
made by or on behalf of the receiving Party to a patent authority as may be reasonably necessary or useful for purposes of obtaining
or enforcing a Patent; provided, however, that reasonable measures shall be taken to assure confidential treatment of such information,
to the extent such protection is available;

 

6.2.4
made by or on behalf of the receiving Party (where Titan is the receiving Party) to any Person in the medical or academic
community that, on an unsolicited basis, has inquired about a Licensed Product (and the research and Development in respect thereof),
including in connection with a proposal to conduct an investigator initiated trial (“IIT”) with respect to
a Licensed Product, for the purpose of referring such Person to Ocular for further discussion; or

 

6.2.5
made by or on behalf of the receiving Party to potential or actual investors, acquirers, licensees or Sublicensees as may be necessary
in connection with their evaluation of such potential or actual investment, acquisition, license or sublicense; provided, however,
that such persons shall be subject to obligations of confidentiality and non-use with respect to such Confidential Information substantially
similar to the obligations of confidentiality and non-use of the receiving Party pursuant to this Article 6 (with a duration of confidentiality
and non-use obligations as appropriate that is no less than five (5) years from the date of disclosure); provided, further, that
if either Party seeks to disclose the terms of this Agreement to potential investors, acquirers, licensees or Sublicensees, the Party
seeking to disclose this Agreement must obtain the other Party’s prior written consent before disclosing this Agreement (such consent
not to be unreasonably withheld, delayed or conditioned).

 

6.3
Use of Name. Except as expressly provided herein, neither Party shall mention or otherwise use the name, logo or Trademark
of the other Party or any of its Affiliates or any of its or their (sub)licensees (or Sublicensees) (or any abbreviation or adaptation
thereof) in any publication, press release, marketing and promotional material or other form of publicity without the prior written approval
in accordance with the provisions of Section 10.6 of such other Party in each instance. The restrictions imposed by this Section 6.3
shall not prohibit (i) either Party from making any disclosure identifying the other Party to the extent required in connection with
its exercise of its rights or obligations under this Agreement and (ii) either Party from making any disclosure identifying the other
Party that is required by Applicable Law or the rules of a stock exchange on which the securities of the disclosing Party are listed
(or to which an application for listing has been submitted).

 

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6.4
SEC Filings and Other Disclosures. In addition to permitted disclosures under Section 6.2, either Party may also disclose
the terms of this Agreement to the extent required, in the reasonable opinion of such Party’s legal counsel, to comply with
Applicable Law, including the rules and regulations promulgated by the U.S. Securities and Exchange Commission. Before disclosing
this Agreement or any of the terms hereof pursuant to this Section 6.4, the Parties will consult with one another on the terms of
this Agreement to be redacted in making any such disclosure, with the disclosing Party providing as much advanced notice as is
feasible under the circumstances, and giving consideration to the comments of the other Party. Further, if a Party discloses this
Agreement or any of the terms hereof in accordance with this Section 6.4, such Party will, at its own expense, seek such
confidential treatment of the financial terms and other confidential portions of this Agreement and such other terms, as may be
reasonably requested by the other Party.

 

6.5
Public Announcements. Neither Party shall issue any public announcement, press release or other public disclosure regarding this
Agreement or its subject matter without the other Party’s prior written consent, in accordance with the provisions of Section 10.6,
except that such consent shall not be required for any such public announcement, press release or other disclosure that is (i) in the
opinion of the disclosing Party’s counsel, required by Applicable Law or made pursuant to any rules or regulations of the U.S.
Securities Exchange Commission or any securities exchange on which the securities of the disclosing Party or any of its Affiliates are
listed or traded (or to which an application for listing has been submitted), or (ii) issued in connection with routine or required filings
made pursuant to any rules or regulations of the U.S. Securities Exchange Commission or any securities exchange on which the securities
of the disclosing Party or any of its Affiliates are listed or traded (or to which an application for listing has been submitted). Each
Party shall submit any proposed disclosure in writing to the other Party as far in advance as reasonably practicable (and in no event
less than five (5) Business Days prior to the anticipated date of disclosure) so as to provide a reasonable opportunity to comment thereon.
Neither Party shall be required to seek the permission of the other Party to repeat any information regarding the terms of this Agreement
or any amendment hereto that has already been publicly disclosed by such Party or by the other Party, in accordance with this Section
6.5; provided that such information remains accurate as of such time and provided the frequency and form of such disclosure are
reasonable.

 

6.6
Return of Confidential Information. Upon the effective date of the expiration or termination of this Agreement for any reason, either
Party may request in writing and the non-requesting Party shall either, with respect to Confidential Information to which such non-requesting
Party does not retain rights under the surviving provisions of this Agreement, at the non-requesting Party’s election, (i) promptly
destroy all copies of such Confidential Information in the possession or control of the non-requesting Party and confirm such destruction
in writing to the requesting Party or (ii) promptly deliver to the requesting Party, at the non-requesting Party’s sole cost and
expense, all copies of such Confidential Information in the possession or control of the non-requesting Party. Notwithstanding the foregoing,
the non-requesting Party shall be  permitted to retain such Confidential Information (x) to the
extent necessary or useful for purposes of performing any continuing obligations or exercising any ongoing rights hereunder and, in any
event, a single copy of such Confidential Information for archival purposes and (y) any computer records or files containing such Confidential
Information that have been created solely by such non-requesting Party’s automatic archiving and back-up procedures, to the extent
created and retained in a manner consistent with such non-requesting Party’s standard archiving and back-up procedures, but not
for any other uses or purposes. All Confidential Information shall continue to be subject to the terms of this Agreement for the period
set forth in Section 6.1.

 

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ARTICLE
7

REPRESENTATIONS AND WARRANTIES; COVENANTS

 

7.1
Mutual Representations and Warranties. Each of Ocular and Titan represents and warrants to the other, as of the Effective Date, and
covenants, that:

 

7.1.1
It is a corporation duly organized, validly existing and in good standing under the laws of the jurisdiction of its organization
and has all requisite power and authority, corporate or otherwise, to execute, deliver and perform this Agreement;

 

7.1.2
The execution and delivery of this Agreement and the performance by it of the transactions contemplated hereby have been duly authorized
by all necessary corporate action and do not violate: (i) such Party’s charter documents, bylaws or other organizational documents;
(ii) in any material respect, any agreement, instrument or contractual obligation to which such Party is bound; (iii) any requirement
of any Applicable Law; or (iv) any order, writ, judgment, injunction, decree, determination or award of any court or governmental agency
presently in effect applicable to such Party;

 

7.1.3
This Agreement is a legal, valid and binding obligation of such Party enforceable against it in accordance with its terms and conditions,
subject to the effects of bankruptcy, insolvency or other laws of general application affecting the enforcement of creditors rights,
judicial principles affecting the availability of specific performance and general principles of equity (whether enforceability is considered
a proceeding at law or equity); and

 

7.1.4
It is not under any obligation, contractual or otherwise, to any Person that conflicts with or is inconsistent in any material respect
with the terms of this Agreement or that would impede the diligent and complete fulfillment of its obligations hereunder.

 

7.2
Additional Representations and Warranties of Titan. Titan further represents and warrants to Ocular, as of the Effective Date,
that:

 

7.2.1
Titan is the sole and exclusive owner of the Patent Applications;

 

7.2.2
Titan Controls the Patent Applications and has the right to grant to Ocular the rights in relation to the Patent Applications that
Titan purports to grant hereunder and, upon filing of the Continuing Application, will Control the Continuing Application and

 

7.2.3
Solely to the extent that the inaccuracy of the following statements would have a material adverse effect on Ocular’s Exploitation
of a Licensed Product:

 

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(i)
to the knowledge of Titan and except to the extent not yet due as of the Effective Date, all necessary and material application fees,
registration fees, maintenance fees and renewal fees in respect of the Patent Applications have been paid and, except to the extent not
yet due as of the Effective Date, all necessary and material documents and certificates have been filed with the relevant agencies for
the purpose of maintaining such Patent Applications; and

 

(ii)
except as set forth in Schedule 7.2.3, to the knowledge of Titan, there is no pending or threatened claim, judgment, interference or
opposition against Titan relating to the Patent Applications.

 

7.3
Additional Covenants of Titan. Titan further covenants to Ocular that:

 

7.3.1
Titan shall be the sole and exclusive owner of the Continuing Application when filed;

 

7.3.2
Titan will Control the Continuing Application when filed and will have the right when filed to grant to Ocular the licenses and sublicenses
in relation to the Continuing Application that Titan purports to grant hereunder (which grants shall be deemed to take place automatically
upon such filing); and

 

7.3.3
Solely to the extent that the inaccuracy of the following statements would have a material adverse effect on Ocular’s Exploitation
of a Licensed Product:

 

(i)
to the knowledge of Titan and except to the extent not yet due as of the Effective Date, all necessary and material application fees,
registration fees, maintenance fees and renewal fees in respect of the Continuing Application, will be paid and, except to the extent
not yet due as of the Effective Date, all necessary and material documents and certificates will be filed with the relevant agencies
for the purpose of maintaining such Continuing Application; and

 

(ii)
except as set forth in Schedule 7.2.3, to the knowledge of Titan as of the Effective Date, there is no pending or threatened claim, judgment,
interference or opposition against Titan relating to the Continuing Application.

 

7.3.4
Titan shall take action to respond to the June 7, 2022 U.S. Patent and Trademark Office action to maintain pendency by filing, at
a minimum, for a three (3) month extension in order to assure the co-pendency of the Continuing Application with Patent Application no.
16/388,962.

 

7.3.5
Titan, on behalf of itself and its successors, assigns, and other legal representatives, hereby absolutely, unconditionally and irrevocably,
covenants and agrees with and in favor of Ocular that it will not sue (at law, in equity, in any regulatory proceeding or otherwise)
Ocular on the basis of any ophthalmic use of the Patent Applications.

 

7.4
Additional Covenants of Ocular. Ocular, on behalf of itself and its successors, assigns, and other legal representatives, hereby
absolutely, unconditionally and irrevocably, covenants and agrees with and in favor of Titan that it will not sue (at law, in equity,
in any regulatory proceeding or otherwise) Titan on the basis of any non-ophthalmic use of the Patent Applications.

 

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7.5
DISCLAIMER OF WARRANTIES. EXCEPT FOR THE EXPRESS WARRANTIES SET FORTH HEREIN (A) NEITHER PARTY MAKES ANY REPRESENTATIONS OR GRANTS
ANY WARRANTIES, EXPRESS OR IMPLIED, EITHER IN FACT OR BY OPERATION OF LAW, BY STATUTE OR OTHERWISE AND EACH PARTY SPECIFICALLY DISCLAIMS
ANY OTHER WARRANTIES, WHETHER WRITTEN OR ORAL OR EXPRESS OR IMPLIED, INCLUDING ANY WARRANTY OF QUALITY, MERCHANTABILITY OR FITNESS FOR
A PARTICULAR USE OR PURPOSE OR ANY WARRANTY AS TO THE VALIDITY OF ANY PATENTS OR THE NON-INFRINGEMENT OF ANY INTELLECTUAL PROPERTY RIGHTS
OF THIRD PARTIES AND (B) OCULAR ACKNOWLEDGES AND AGREES THAT TITAN MAKES NO REPRESENTATIONS OR GRANTS ANY WARRANTIES, EXPRESS OR IMPLIED,
EITHER IN FACT OR BY OPERATION OF LAW, BY STATUTE OR OTHERWISE THAT ANY LICENSED PRODUCT DOES NOT INFRINGE THE PATENTS OR OTHER INTELLECTUAL
PROPERTY RIGHTS OF ANY THIRD PARTY.

 

7.6
ADDITIONAL WAIVER. EXCEPT FOR THE EXPRESS PROVISIONS SET OUT HEREIN, OCULAR AGREES THAT: (i) THE PATENT APPLICATIONS AND CONTINUING
APPLICATION ARE LICENSED “AS IS,” “WITH ALL FAULTS,” AND “WITH ALL DEFECTS,” AND OCULAR EXPRESSLY
WAIVES ALL RIGHTS TO MAKE ANY CLAIM WHATSOEVER AGAINST TITAN FOR MISREPRESENTATION OR FOR BREACH OF PROMISE, GUARANTEE OR WARRANTY OF
ANY KIND RELATING TO THE LICENSED PATENTS; (ii) OCULAR AGREES THAT TITAN WILL HAVE NO LIABILITY TO OCULAR FOR ANY ACT OR OMISSION IN
THE PREPARATION, FILING, PROSECUTION, MAINTENANCE, ENFORCEMENT, DEFENSE OR OTHER HANDLING OF THE PATENT APPLICATIONS OR CONTINUING APPLICATION;
AND (iii) OCULAR IS SOLELY RESPONSIBLE FOR DETERMINING WHETHER THE LICENSED PATENTS HAVE APPLICABILITY OR UTILITY IN OCULAR’S CONTEMPLATED
EXPLOITATION OF THE LICENSED PRODUCTS AND OCULAR ASSUMES ALL RISK AND LIABILITY IN CONNECTION WITH SUCH DETERMINATION.

 

ARTICLE 8

INDEMNITY

 

8.1
Indemnification of Titan. Ocular shall indemnify Titan, its Affiliates, its or their (sub)licensees (or Sublicensees) and
its and their respective directors, officers, employees and agents, and defend and save each of them harmless, from and against
any and all losses, damages, liabilities, costs and expenses (including reasonable attorneys’ fees and expenses) (collectively,
“Losses”) incurred in connection with any and all suits, investigations, claims or demands of Third Parties
(collectively, “Third Party Claims”) arising from, relating to, or occurring as a result of: (i) the breach
by Ocular of this Agreement, including the enforcement of Titan’s rights under this Section 8.1; (ii) the gross negligence
or willful misconduct on the part of Ocular or its Affiliates or its or their respective directors, officers, employees or agents
in performing its or their obligations under this Agreement; or (iii) the Exploitation by Ocular or any of its Affiliates or its
or their respective Sublicensees or its or their respective distributors or contractors of any Licensed Product in or for the
Licensed Territory, including any claims of infringement or inducement of infringement of the Intellectual Property Rights of
any Third Party and any product liability claims; except, in each case, for those Losses for which Titan has an obligation to
indemnify Ocular pursuant to Section 8.2 hereof, as to which Losses each Party shall indemnify the other to the extent of their
respective liability.

 

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8.2
Indemnification of Ocular. Titan shall indemnify Ocular, its Affiliates and their respective directors, officers, employees and agents,
and defend and save each of them harmless, from and against any and all Losses incurred in connection with any and all Third Party Claims
arising from, relating to, or occurring as a result of (i) the breach by Titan of this Agreement, including the enforcement of Ocular’s
rights under this Section 8.2; (ii) the gross negligence or willful misconduct on the part of Titan or its Affiliates or its or their
respective directors, officers, employees or agents in performing its obligations under this Agreement; or (iii) the Exploitation by
Titan or any of its Affiliates or its or their respective Sublicensees or its or their respective distributors or contractors of any
product covered by the Licensed Patents outside of the Licensed Territory, including any claims of infringement or inducement of infringement
of the Intellectual Property Rights of any Third Party and any product liability claims; except, in each case, for those Losses for which
Ocular has an obligation to indemnify Titan pursuant to Section 8.1 hereof, as to which Losses each Party shall indemnify the other to
the extent of their respective liability for the Losses.

 

8.3
Indemnification Procedures.

 

8.3.1
Notice of Claim. All indemnification claims in respect of a Party, its Affiliates or its or their (sub)licensees (or
Sublicensees) or their respective directors, officers, employees and agents shall be made solely by such Party to this
Agreement (the “Indemnified Party”). The Indemnified Party shall give the indemnifying Party prompt
written notice (an “Indemnification Claim Notice”) of any Losses or discovery of fact upon which such
indemnified Party intends to base a request for indemnification under this Article 8, but in no event shall the indemnifying
Party be liable for any Losses that result from any delay in providing such notice. Each Indemnification Claim Notice must
contain a description of the claim and the nature and amount of such Loss (to the extent that the nature and amount of such
Loss is known at such time). The Indemnified Party shall furnish promptly to the indemnifying Party copies of all papers and
official documents received in respect of any Losses and Third Party Claims.

 

8.3.2
Control of Defense. The indemnifying Party shall have the right to assume the defense of any Third Party Claim by giving written
notice to the indemnified Party as promptly as practicable, but in any event no later than thirty (30) days after the indemnifying
Party’s receipt of an Indemnification Claim Notice. The assumption of the defense of a Third Party Claim by the Indemnifying
Party shall not be construed as an acknowledgment that the indemnifying Party is liable to indemnify the Indemnified Party in
respect of the Third Party Claim, nor shall it constitute a waiver by the indemnifying Party of any defenses it may assert against
the Indemnified Party’s claim for indemnification. Upon assuming the defense of a Third Party Claim, the indemnifying Party
may appoint as lead counsel in the defense of the Third Party Claim any legal counsel selected by the indemnifying Party; provided that
it obtains the prior written consent of the Indemnified Party (which consent shall not be unreasonably withheld, conditioned or
delayed). In the event the indemnifying Party assumes the defense of a Third Party Claim, the Indemnified Party shall promptly, but
in no event later than five (5) Business Days, deliver to the indemnifying Party all original notices and documents (including court
papers) received by the Indemnified Party in connection with the Third Party Claim. Should the indemnifying Party assume the defense
of a Third Party Claim, except as provided in Section 8.3.3, the indemnifying Party shall not be liable to the Indemnified Party for
any legal expenses subsequently incurred by such Indemnified Party in connection with the analysis, defense or settlement of the
Third Party Claim unless specifically requested in writing by the indemnifying Party. In the event that it is ultimately determined
that the indemnifying Party is not obligated to indemnify, defend or hold harmless the Indemnified Party from and against the Third
Party Claim, the Indemnified Party shall reimburse the indemnifying Party for any and all reasonable and verifiable out-of-pocket
costs and expenses (including attorneys’ fees and costs of suit) and any Losses incurred by the indemnifying Party in
accordance with this Article 8 in its defense of the Third Party Claim.

 

    20

     

    

 

8.3.3
Right to Participate in Defense. Any Indemnified Party shall be entitled to participate in the defense of such Third Party Claim
and to employ counsel of its choice for such purpose; provided, however, that such employment shall be at the Indemnified Party’s
sole cost and expense unless (i) the employment thereof has been specifically authorized in writing by the indemnifying Party (in which
case, the defense shall be controlled as provided in Section 8.3.2), (ii) the indemnifying Party has failed to assume the defense and
employ counsel in accordance with Section 8.3.2 (in which case the Indemnified Party shall control the defense) or (iii) the interests
of the Indemnified Party and the indemnifying Party with respect to such Third Party Claim are sufficiently adverse to prohibit the representation
by the same counsel of both Parties under Applicable Law, ethical rules or equitable principles (in which case, the Indemnified Party
shall control its defense).

 

8.3.4
Settlement. With respect to any Losses relating solely to the payment of money damages in connection with a Third Party Claim and
that shall not result in the applicable indemnitee(s) becoming subject to injunctive or other relief or otherwise adversely affecting
the business of the Indemnified Party in any manner and as to which the indemnifying Party shall have acknowledged in writing the obligation
to indemnify the applicable indemnitee hereunder, the indemnifying Party shall have the sole right to consent to the entry of any judgment,
enter into any settlement or otherwise dispose of such Loss, on such terms as the indemnifying Party, in its sole discretion, shall deem
appropriate. With respect to all other Losses in connection with Third Party Claims, where the indemnifying Party has assumed the defense
of the Third Party Claim in accordance with Section 8.3.2, the indemnifying Party shall have authority to consent to the entry of any
judgment, enter into any settlement or otherwise dispose of such Loss; provided it obtains the prior written consent of the Indemnified
Party (which consent shall not be unreasonably withheld, conditioned or delayed). If the indemnifying Party does not assume and conduct
the defense of a Third Party Claim as provided above, the Indemnified Party may defend against such Third Party Claim and may settle
such Third Party Claim without the prior written consent of the indemnifying Party.

 

8.3.5
Cooperation. Regardless of whether the indemnifying Party chooses to defend or prosecute any Third Party Claim, the Indemnified Party
shall, and shall cause each indemnitee to, cooperate in the defense or prosecution thereof and shall furnish such records, information
and testimony, provide such witnesses and attend such conferences, discovery proceedings, hearings, trials and appeals as may be reasonably
requested in connection therewith. Such cooperation shall include access during normal business hours afforded to the indemnifying Party
to, and reasonable retention by the Indemnified Party of, records and information that are reasonably relevant to such Third Party Claim
and making Indemnified Parties and other employees and agents available on a mutually convenient basis to provide additional information
and explanation of any material provided hereunder and the indemnifying Party shall reimburse the Indemnified Party for all of its, its
Affiliates’ and its and their respective (sub)licensees’ (or Sublicensees’) or their respective directors’, officers’,
employees’ and agents’, as applicable, reasonable and verifiable out-of-pocket expenses in connection therewith.

 

    21

     

    

 

8.3.6
Expenses. Except as provided above, the costs and expenses, including fees and disbursements of counsel, incurred by the Indemnified
Party and its Affiliates and its and their respective (sub)licensees (or Sublicensees) and their respective directors, officers, employees
and agents, as applicable, in connection with any claim shall be reimbursed on a quarterly basis by the indemnifying Party, without prejudice
to the indemnifying Party’s right to contest the Indemnified Party’s right to indemnification and subject to refund in the
event the indemnifying Party is ultimately held not to be obligated to indemnify the Indemnified Party.

 

8.4
Special, Indirect and Other Losses. EXCEPT (i) IN THE EVENT OF WILLFUL MISCONDUCT OR FRAUD OF A PARTY OR OF A PARTY’S BREACH
OF ITS OBLIGATIONS UNDER ARTICLE 6, (ii) AS PROVIDED UNDER SECTION 10.8, OR (iii) TO THE EXTENT ANY SUCH DAMAGES ARE REQUIRED TO BE PAID
TO A THIRD PARTY AS PART OF A CLAIM FOR WHICH A PARTY PROVIDES INDEMNIFICATION UNDER THIS ARTICLE 8, NEITHER PARTY NOR ANY OF ITS AFFILIATES
OR (SUB)LICENSEES (OR SUBLICENSEES) SHALL BE LIABLE IN CONTRACT, TORT, NEGLIGENCE, BREACH OF STATUTORY DUTY OR OTHERWISE FOR ANY SPECIAL
OR PUNITIVE DAMAGES OR FOR LOSS OF PROFITS SUFFERED BY THE OTHER PARTY.

 

8.5
Insurance. During the Term and for six (6) years thereafter, each of Ocular and Titan shall obtain and maintain comprehensive general
liability insurance covering its obligations and activities hereunder with reputable and financially secure insurance carriers in a form
and at levels (i) normal and customary in the pharmaceutical industry generally for parties similarly situated and (ii) otherwise required
by Applicable Law. Upon request by, a Party shall provide to the other Party evidence of its insurance coverage.

 

ARTICLE
9

TERM AND TERMINATION

 

9.1
Term and Expiration. This Agreement shall commence on the Effective Date and, unless earlier terminated in accordance herewith,
shall continue in full force and effect until the date of expiration of the last of the Licensed Patents to expire (such period,
the “Term”).

 

9.2
Termination.

 

9.2.1
Material Breach. In the event that either Party (the “Breaching Party”) shall be in material breach in
the performance of any of its obligations under this Agreement, in addition to any other right and remedy the other Party (the
“Non-Breaching Party”) may have, the Non-Breaching Party may terminate this Agreement by providing thirty (30)
days (the “Notice Period”) prior written notice (the “Termination Notice”) to the Breaching
Party and specifying the breach and its claim of right to terminate; provided that the termination shall not become effective
at the end of the Notice Period if the Breaching Party cures the breach specified in the Termination Notice during the Notice
Period (or, if such default cannot be cured within the Notice Period, if the Breaching Party commences actions to cure such breach
within the Notice Period and thereafter diligently continues such actions).

 

    22

     

    

 

9.2.2
Termination by Ocular. Ocular may terminate this Agreement in its entirety, for any or no reason, upon three (3) months prior written
notice to Titan. Notwithstanding the foregoing, Ocular shall remain responsible to pay to Titan the Milestone Payment payable upon the
issuance of the first Licensed Patent in accordance with Section 4.2.1, regardless of when termination by Ocular occurs under this Section
9.2.2.

 

9.2.3
Termination by Titan. In the event that Ocular or any of its Affiliates or Sublicensees, anywhere in the Licensed Territory, institutes,
prosecutes or otherwise participates in (or in any way aids any Third Party in instituting, prosecuting or participating in), at law
or in equity or before any administrative or regulatory body, including the U.S. Patent and Trademark Office or its foreign counterparts,
any claim, demand, action or cause of action for declaratory relief, damages or any other remedy or for an enjoinment, injunction or
any other equitable remedy, including any interference, re-examination, inter partes review, opposition or any similar proceeding,
alleging that any claim in a Licensed Patent is invalid, unenforceable or otherwise not patentable or would not be infringed by Ocular’s
activities absent the rights and licenses granted hereunder, Titan shall have the right to immediately terminate this Agreement in its
entirety, including the rights of any Sublicensees, upon written notice to Ocular.

 

9.2.4
Termination for Insolvency. In the event that either Party (i) files for protection under bankruptcy or insolvency laws, (ii)
makes an assignment for the benefit of creditors, (iii) appoints or suffers appointment of a receiver or trustee over substantially
all of its property that is not discharged within ninety (90) days after such filing, (iv) proposes a written agreement of composition
or extension of its debts, (v) proposes or is a party to any dissolution or liquidation, (vi) files a petition under any bankruptcy
or insolvency act or has any such petition filed against it that is not discharged within sixty (60) days of the filing thereof
or (vii) admits in writing to the other Party or publicly admits in writing its inability generally to meet its obligations as
they fall due in the general course and such writing is not rescinded within sixty (60) days of the delivery or disclosure thereof
(each of (i) through (vii), an “Insolvency Event”), then the other Party may terminate this Agreement in its
entirety with immediate effect upon providing written notice to the Party to which the Insolvency Event relates.

 

9.3
Rights in Bankruptcy. All rights and licenses granted under or pursuant to this Agreement by Titan are and shall otherwise be
deemed to be, for purposes of Section 365(n) of the U.S. Bankruptcy Code or any analogous provisions in any other country or
jurisdiction, licenses of right to “intellectual property” as defined under Section 101 of the U.S. Bankruptcy Code.
Titan agrees that Ocular, as licensee of such rights under this Agreement, shall retain and may fully exercise all of its rights and
elections under the U.S. Bankruptcy Code or any analogous provisions in any other country or jurisdiction. Titan further agrees
that, in the event of the commencement of a bankruptcy proceeding by or against Titan under the U.S. Bankruptcy Code or any
analogous provisions in any other country or jurisdiction, Ocular shall be entitled to a complete duplicate of (or complete access
to, as appropriate) any such intellectual property and all embodiments of such intellectual property, which, if not already in
Ocular’s possession, shall be promptly delivered to it (i) upon any such commencement of a bankruptcy proceeding upon
Ocular’s written request therefor, unless Titan, as subject to such proceeding elects to continue to perform all of its
obligations under this Agreement or (ii) if not delivered under clause (i) above, following the rejection of this Agreement by or on
behalf of Titan, upon written request therefor by Ocular.

 

    23

     

    

 

9.4
Consequences of Termination. In the event of a termination of this Agreement for any reason, all rights and licenses granted by
Titan hereunder shall immediately terminate, including, for clarity, any sublicense granted by Ocular pursuant to Section 2.2.
Except as otherwise provided in Section 9.2.2, upon termination of this Agreement each Party shall be responsible for obligations or
liabilities that have accrued on or prior to the date of termination.

 

9.5
Remedies. Except as otherwise expressly provided herein, termination of this Agreement in accordance with the provisions hereof shall
not limit remedies that may otherwise be available to either Party in law or equity.

 

9.6
Accrued Rights; Surviving Obligations. Termination or expiration of this Agreement for any reason shall be without prejudice to any
rights that shall have accrued to the benefit of a Party prior to such termination or expiration. Such termination or expiration shall
not relieve a Party from obligations that are expressly indicated to survive the termination or expiration of this Agreement. Without
limiting the foregoing, Sections 3.1.3, 4.3 through 4.5, 7.3.3(ii) and 7.5, and Article 1 (to the extent defined terms are contained
in the surviving Articles and Sections), Article 6, Article 8, Article 9 and Article 10 of this Agreement shall survive the termination
or expiration of this Agreement for any reason.

 

ARTICLE
10

MISCELLANEOUS

 

10.1
Force Majeure. Neither Party shall be held liable or responsible to the other Party or be deemed to have defaulted under or breached
this Agreement for failure or delay in fulfilling or performing any term of this Agreement (other than an obligation to make payments)
when such failure or delay is caused by or results from events beyond the reasonable control of the nonperforming Party, including fires,
floods, earthquakes, hurricanes, embargoes, shortages, epidemics, quarantines, war, acts of war (whether war be declared or not), terrorist
acts, insurrections, riots, civil commotion, strikes, lockouts or other labor disturbances (whether involving the workforce of the non-performing
Party or of any other Person), acts of God or acts, omissions or delays in acting by any Governmental Authority (except to the extent
such delay results from the breach by the non-performing Party or any of its Affiliates of any term or condition of this Agreement).
The non-performing Party shall notify the other Party of such force majeure within thirty (30) days after such occurrence by giving written
notice to the other Party stating the nature of the event, its anticipated duration and any action being taken to avoid or minimize its
effect. The suspension of performance shall be of no greater scope and no longer duration than is necessary and the non-performing Party
shall use commercially reasonable efforts to remedy its inability to perform.

 

    24

     

    

 

10.2
Assignment. Neither Party may assign its rights or delegate its obligations under this Agreement, whether by operation of
law or otherwise, in whole or in part without the prior written consent of the other Party, which consent shall not be unreasonably
withheld, conditioned or delayed, except that; (A) Titan shall have the right, without such consent, to (i) perform any
or all of its obligations and exercise any or all of its rights under this Agreement through any of its Affiliates or its or their
(sub)licensees (or Sublicensees), and (ii) assign any or all of its rights and delegate any or all of its obligations hereunder
to any of its Affiliates or its or their (sub)licensees (or Sublicensees) or to any successor in interest (whether by merger,
acquisition, asset purchase or otherwise and whether on a worldwide or country-by-country basis) to (x) the Licensed Patents,
or (y) all or substantially all of the business to which this Agreement relates; and (B) Ocular shall have the right, without
such consent, to (i) perform any or all of its obligations and exercise any or all of its rights under this Agreement through
any of its Affiliates and (ii) assign any or all of its rights and delegate any or all of its obligations hereunder to any of
its Affiliates or to any successor in interest (whether by merger or acquisition); provided that (i) any such successor
in interest to Ocular shall have sufficient financial liquidity, resources and expertise to fulfill its obligations under this
Agreement at the time of such merger or acquisition, and (ii) Titan and Ocular shall provide written notice to the other within
thirty (30) days after such assignment or delegation. Any permitted successor of a Party or any permitted assignee of all of a
Party’s rights under this Agreement that has also assumed all of such Party’s obligations hereunder in writing shall,
upon any such succession or assignment and assumption, be deemed to be a party to this Agreement as though named herein in substitution
for the assigning Party, whereupon the assigning Party shall cease to be a party to this Agreement and shall cease to have any
rights or obligations under this Agreement. All validly assigned rights of a Party shall inure to the benefit of and be enforceable
by, and all validly delegated obligations of such Party shall be binding on and be enforceable against, the permitted successors
and assigns of such Party; provided that such Party, if it survives, shall remain jointly and severally liable for the
performance of such delegated obligations under this Agreement. Any attempted assignment or delegation in violation of this Section
10.2 shall be void and of no effect.

 

10.3
Severability. If any provision of this Agreement is held to be illegal, invalid or unenforceable under any present or future law
and if the rights or obligations of either Party under this Agreement will not be materially and adversely affected thereby, (i) such
provision shall be fully severable, (ii) this Agreement shall be construed and enforced as if such illegal, invalid or unenforceable
provision had never comprised a part hereof, (iii) the remaining provisions of this Agreement shall remain in full force and effect and
shall not be affected by the illegal, invalid or unenforceable provision or by its severance herefrom and (iv) in lieu of such illegal,
invalid or unenforceable provision, there shall be added automatically as a part of this Agreement a legal, valid and enforceable provision
as similar in terms to such illegal, invalid or unenforceable provision as may be possible and reasonably acceptable to the Parties.
To the fullest extent permitted by Applicable Law, each Party hereby waives any provision of law that would render any provision hereof
illegal, invalid or unenforceable in any respect.

 

10.4
Dispute Resolution. Except as provided in Section 10.8, if a dispute arises between the Parties in connection with or relating
to this Agreement or any document or instrument delivered in connection herewith (collectively, a “Dispute”),
then either Party shall have the right to refer such Dispute to the Senior Officers for attempted resolution by good faith negotiations
during a period of ten (10) Business Days. Any final decision mutually agreed to by the Senior Officers shall be conclusive and
binding on the Parties. In the event the Senior Officers are unable to resolve any Dispute in accordance with the provisions of
this Section 10.4, the provisions of Section 10.5 shall apply.

 

    25

     

    

 

10.5
Governing Law, Jurisdiction and Service.

 

10.5.1
Governing Law. This Agreement shall be governed by and construed in accordance with the laws of the State of Delaware, excluding
any conflicts or choice of law rule or principle that might otherwise refer construction or interpretation of this Agreement to the substantive
law of another jurisdiction.

 

10.5.2
Jurisdiction. Subject to Section 10.4 and Section 10.8, the Parties hereby irrevocably and unconditionally consent to the exclusive
jurisdiction of state and federal courts for the State of Delaware for any action, suit or proceeding (other than appeals therefrom)
arising out of or relating to this Agreement and agree not to commence any action, suit or proceeding (other than appeals therefrom)
related thereto except in such courts. THE PARTIES IRREVOCABLY AND UNCONDITIONALLY WAIVE THEIR RIGHT TO A JURY TRIAL.

 

10.5.3
Venue. The Parties further hereby irrevocably and unconditionally waive any objection to the laying of venue of any action, suit
or proceeding (other than appeals therefrom) arising out of or relating to this Agreement in the state and federal courts for the State
of Delaware and hereby further irrevocably and unconditionally waive and agree not to plead or claim in any such court that any such
action, suit or proceeding brought in any such court has been brought in an inconvenient forum.

 

10.5.4
Service. Each Party further agrees that service of any process, summons, notice or document by registered mail to its address set
forth in Section 10.6.2 shall be effective service of process for any action, suit or proceeding brought against it under this Agreement
in any such court.

 

10.6
Notices.

 

10.6.1
Notice Requirements. Any notice, request, demand, waiver, consent, approval or other communication permitted or required under
this Agreement shall be in writing, shall refer specifically to this Agreement and shall be deemed given only if delivered (i)
by hand, (ii) by facsimile transmission (with transmission confirmed), (iii) by nationally recognized overnight delivery service
that maintains records of delivery or (iv) by electronic mail, including a PDF image, with signature(s), including digital signatures,
as applicable (with delivery receipt), (in each case of (i)-(iv) addressed to the Parties at their respective addresses specified
in Section 10.6.2 or to such other address as the Party to whom notice is to be given may have provided to the other Party in
accordance with this Section 10.6.1). Such Notice shall be deemed to have been given as of the date delivered by hand or transmitted
by facsimile (with transmission confirmed), or on the second Business Day (at the place of delivery) after deposit with a nationally
recognized overnight delivery service or delivery by electronic mail (with delivery receipt). Any notice delivered by facsimile
or electronic mail shall be confirmed by a hard copy delivered as soon as practicable thereafter. This Section 10.6.1 is not intended
to govern the day-to-day business communications necessary between the Parties in performing their obligations under the terms
of this Agreement.

 

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10.6.2
Address for Notice.

 

If to Ocular, to:

 

Ocular
Therapeutix, Inc.

24
Crosby Drive

Bedford,
MA 01730

Attention:
Chief Financial Officer

E-mail:
DNottman@ocutx.com

 

with
a copy (which shall not constitute notice) to:

 

Arnold
& Porter Kaye Scholer LLP

250
West 55th Street

New
York, NY 10019

Attention:
Rory Greiss

E-mail:
rory.greiss@arnoldporter.com

 

If
to Titan, to:

 

Titan
Pharmaceuticals

400
Oyster Point Blvd., Suite 500

South
San Francisco, CA 94080

Attention:
Kate Beebe DeVarney, Ph.D.

E-mail: Kdevarney@titanpharm.com

 

10.7
Entire Agreement; Amendments. This Agreement, together with the Schedules attached hereto, sets forth and constitutes the entire
agreement and understanding between the Parties with respect to the subject matter hereof and all prior agreements, understandings, promises
and representations, whether written or oral, with respect thereto are superseded hereby. Each Party hereby confirms that it is not relying
on any representations or warranties of the other Party except as specifically set forth in this Agreement. No amendment, modification,
release or discharge shall be binding on the Parties unless in writing and duly executed by authorized representatives of both Parties.
In the event of any inconsistencies between this Agreement and any schedules or other attachments hereto, the terms of this Agreement
shall control.

 

10.8
Equitable Relief. Each Party acknowledges and agrees that the restrictions set forth in Article 5 and Article 6 are reasonable
and necessary to protect the legitimate interests of the other Party and that such other Party would not have entered into this
Agreement in the absence of such restrictions and that any breach or threatened breach of any provision of such Articles may result
in irreparable injury to such other Party for which there will be no adequate remedy at law. In the event of a breach or threatened
breach of any provision of such Articles, the non-breaching Party shall be authorized and entitled to seek from any court of
competent jurisdiction injunctive relief, whether preliminary or permanent, specific performance and an equitable accounting of all
earnings, profits and other benefits arising from such breach, which rights shall be cumulative and in addition to any other rights
or remedies to which such non-breaching Party may be entitled in law or equity. Both Parties agree to waive any requirement that the
other Party (i) post a bond or other security as a condition for obtaining any such relief and (ii) show irreparable harm, balancing
of harms, consideration of the public interest or inadequacy of monetary damages as a remedy. Nothing in this Section 10.8 is
intended or should be construed to limit either Party’s right to equitable relief or any other remedy for a breach of any
other provision of this Agreement.

 

    27

     

    

 

10.9
Waiver and Non-Exclusion of Remedies. Any term or condition of this Agreement may be waived at any time by the Party that is entitled
to the benefit thereof, but no such waiver shall be effective unless set forth in a written instrument duly executed by or on behalf
of the Party waiving such term or condition. The waiver by either Party hereto of any right hereunder or of the failure to perform or
of a breach by the other Party shall not be deemed a waiver of any other right hereunder or of any other breach or failure by such other
Party whether of a similar nature or otherwise. The rights and remedies provided herein are cumulative and do not exclude any other right
or remedy provided by Applicable Law or otherwise available except as expressly set forth herein.

 

10.10
No Benefit to Third Parties. Except as provided in Article 8, covenants and agreements set forth in this Agreement are for the sole
benefit of the Parties hereto and their successors and permitted assigns and they shall not be construed as conferring any rights on
any other Persons.

 

10.11
Further Assurance. Each Party shall duly execute and deliver, or cause to be duly executed and delivered, such further instruments
and do and cause to be done such further acts and things, including the filing of such assignments, agreements, documents and instruments,
as may be necessary or as the other Party may reasonably request in connection with this Agreement or to carry out more effectively the
provisions and purposes hereof or to better assure and confirm unto such other Party its rights and remedies under this Agreement.

 

10.12
Relationship of the Parties. It is expressly agreed that Titan, on the one hand and Ocular, on the other hand, shall be independent
contractors and that the relationship between the two Parties shall not constitute a partnership, joint venture or agency. Neither Titan,
on the one hand, nor Ocular, on the other hand, shall have the authority to make any statements, representations or commitments of any
kind or to take any action that will be binding on the other, without the prior written consent of the other Party to do so. All persons
employed by a Party shall be employees of such Party and not of the other Party and all costs and obligations incurred by reason of any
such employment shall be for the account and expense of such first Party.

 

10.13
References. Unless otherwise specified, (i) references in this Agreement to any Article, Section, Schedule or Exhibit shall mean
references to such Article, Section, Schedule or Exhibit of this Agreement, (ii) references in any Section to any clause are references
to such clause of such Section and (iii) references to any agreement, instrument or other document in this Agreement refer to such agreement,
instrument or other document as originally executed or, if subsequently amended, replaced or supplemented from time to time, as so amended,
replaced or supplemented and in effect at the relevant time of reference thereto.

 

    28

     

    

 

10.14
Construction. The language in this Agreement is to be construed in all cases according to its fair meaning. Except where the context
otherwise requires, wherever used, the singular includes the plural, the plural the singular, the use of any gender applies to all genders
and the word “or” is used in the inclusive sense (and/or). Whenever this Agreement refers to a number of days, unless otherwise
specified, such number refers to calendar days. The captions of this Agreement are for convenience of reference only and in no way define,
describe, extend, or limit the scope or intent of this Agreement or the intent of any provision contained in this Agreement. The term
“including,” “include,” or “includes” means including, without limiting the generality of any description
preceding such term. Unless the context requires otherwise, (i) any reference to any Applicable Law will be construed as referring to
such Applicable Law as from time to time enacted, repealed or amended, (ii) the word “notice” means notice in writing (whether
or not specifically stated) and includes notices, consents, approvals and other written communications contemplated under this Agreement,
(iii) any reference to any Person will be construed to include the Person’s successors and permitted assigns, (iv) the words “herein,”
“hereof” and “hereunder,” and words of similar import, will be construed to refer to this Agreement in its entirety
and not to any particular provision hereof, (v) provisions that require that a Party or the Parties to “agree,” “consent”
or “approve” or the like require that such agreement, consent or approval be specific and in writing, whether by written
agreement, letter, approved minutes or otherwise (but excluding e-mail and instant messaging), (vi) any reference to the words “mutually
agree” or “mutual written agreement” will not impose any obligation on either Party to agree to any terms relating
thereto or to engage in discussions relating to such terms except as such Party may determine in such Party’s sole discretion,
(vii) the words “copy” and “copies” and words of similar import when used in this Agreement include, to the extent
available, electronic copies, files or databases containing the information, files, items, documents or materials to which such words
apply, and (viii) except as otherwise expressly provided herein all references to “$” or “Dollars” refer to the
lawful money of the U.S. The headings of each Article and Section in this Agreement have been inserted for convenience of reference only
and are not intended to limit or expand on the meaning of the language contained in the particular Article or Section. Each Party represents
that it has been represented by legal counsel in connection with this Agreement and acknowledges that it has participated in the drafting
hereof. In interpreting and applying the terms and provisions of this Agreement, the Parties agree that no presumption will apply against
the Party which drafted such terms and provisions.

 

10.15
Counterparts. This Agreement may be executed in two (2) or more counterparts, each of which shall be deemed an original, but all
of which together shall constitute one and the same instrument. This Agreement may be executed by facsimile, PDF format via e-mail or
other electronically transmitted signatures and such signatures shall be deemed to bind each Party hereto as if they were original signatures.

 

[SIGNATURE
PAGE FOLLOWS]

 

    29

     

    

 

THIS
AGREEMENT IS EXECUTED by the authorized representatives of the Parties as of the date first written above.

 

	TITAN PHARMACEUTICALS, INC.	 	OCULAR THERAPEUTIX, INC.
	 	 	 	 	 
	By:	/s/ Kate Beebe
  DeVarney, Ph.D.	 	By:	/s/
  Donald Notman
	Name:	Kate Beebe DeVarney, Ph.D.	 	Name:	Donald Notman
	Title:	President and Chief Operating Officer	 	Title:	Chief Financial Officer

 

[Signature Page to License
Agreement]

 

     

     

    

 

Schedule
1.52

Patent Applications and Continuing Application

 

Patent
Applications

 

		1.	U.S.
Provisional Application No. 62/404,643
		2.	PCT/US2017/055432
		3.	U.S.
Patent Application No. 16/338,962

 

Continuing
Application

 

     

     

    

 

 

Schedule
7.2.3

Patent Application Claims

 

None.EX-10.1

 Exhibit 10.1 

Stockholder Support Agreement 

Execution Copy 

STOCKHOLDER SUPPORT AGREEMENT, dated as of December 8, 2022 (this “Agreement”), by and among GigCapital5, Inc., a
Delaware corporation (“GigCapital5”), and certain of the stockholders of QT Imaging, Inc., a Delaware corporation (the “Company”), whose names appear on the signature pages of this Agreement (each, a
“Stockholder” and, collectively, the “Stockholders”). 
 RECITALS 

WHEREAS, GigCapital5, QTI Merger Sub, Inc., a Delaware corporation and wholly owned subsidiary of GigCapital5 (“Merger
Sub”), and the Company have negotiated a Business Combination Agreement in the form attached hereto as Exhibit B (the “BCA”; terms used but not defined in this Agreement shall have the meanings ascribed to
them in the BCA), which provides, among other things, that, upon the terms and subject to the conditions thereof, Merger Sub will merge with and into the Company (the “Merger”), with the Company surviving the Merger as a wholly
owned subsidiary of GigCapital5; and 
 WHEREAS, as of the date hereof, each Stockholder owns of record the number of shares of
Company Common Stock and Company Preferred Stock as set forth opposite such Stockholder’s name on Exhibit A hereto (all such shares of Company Common Stock and Company Preferred Stock and any shares of Company Common Stock and
Company Preferred Stock of which ownership of record or the power to vote is hereafter acquired by the Stockholders prior to the termination of this Agreement being referred to herein as the “Shares”). 

AGREEMENT 
 NOW,
THEREFORE, in consideration of the foregoing and of the mutual covenants and agreements contained herein, and intending to be legally bound hereby, the parties hereto hereby agree as follows: 

1. BCA Approved; Agreement to Vote. Each Stockholder, with respect to such Stockholder’s Shares, severally and not jointly, hereby
agrees to vote, at any meeting of the Stockholders of the Company, and in any action by written consent of the Stockholders of the Company (which written consent shall be delivered promptly, and in any event within forty eight (48) hours, after
the Company requests such delivery), all of the Shares held by such Stockholder at such time in favor of the approval and adoption of the BCA and approval of the Merger and all other transactions contemplated by the BCA, provided in
all cases that no changes have been made in the BCA or in the Merger or related transactions or ancillary agreements under the BCA that are material to one or more of the Stockholders. Provided no changes are made in the BCA or in the Merger or
related transactions or ancillary agreements under the BCA that are material to one or more of the Stockholders, each Stockholder, severally and not jointly, hereby agrees to vote at any meeting of the Stockholders of the Company, and to act by
written consent of Company Stockholders, against any action, agreement, transaction or proposal that would cause a material breach of any covenant, representation, warranty or other obligation or agreement of the Company under the BCA or that would
reasonably be expected to prevent the Merger from being consummated. Each Stockholder acknowledges receipt and review of a copy of the BCA. 

2. Termination of Stockholder Rights. Subject to consummation of the Closing pursuant to the BCA, each Stockholder, severally and not
jointly, hereby agrees that, if applicable to such Stockholder, any rights under Article VII (Transfer of Shares and Admission of New Stockholders) and Article VIII (Tag Along Rights) of the Company’s Bylaws, as amended, and any
rights under any letter agreement providing for redemption rights, put rights, purchase rights or similar rights not generally available to Stockholders of the Company (the “Terminating Rights”) between such Stockholder and the
Company, shall terminate (and such Stockholder, without any further action, shall automatically and irrevocably release and waive any claim such Stockholder may have thereunder) 

 
immediately prior to the Closing under the BCA, and prior thereto such Stockholder shall not exercise such rights in any manner inconsistent with the BCA or otherwise reasonably likely to
interfere with, delay, impede, frustrate or prevent the consummation of the Merger. For the avoidance of doubt, the Terminating Rights shall exclude any rights such Stockholder may have that relate to any commercial or employment agreements or
arrangements between such Stockholder and the Company or any subsidiary of the Company, which shall survive in accordance with their terms. 

3. Transfer of Shares. Each Stockholder, severally and not jointly, agrees that he, she or it shall not, directly or indirectly,
(a) sell, assign, transfer (including by operation of law), create any lien or pledge, dispose of or otherwise encumber any of the Shares or otherwise agree to do any of the foregoing, except for a sale, assignment or transfer pursuant to the
BCA or to another Stockholder of the Company that is a party to this Agreement and bound by the terms and obligations hereof, (b) deposit any Shares into a voting trust or enter into a voting agreement or arrangement or grant any proxy or power
of attorney with respect thereto that is inconsistent with this Agreement or (c) enter into any contract, option or other arrangement or undertaking with respect to the direct acquisition or sale, assignment, transfer or other disposition of
any Shares, except as set forth in the BCA or this Agreement; provided, that the foregoing shall not prohibit the transfer of the Shares to an affiliate of Stockholder, but only if such affiliate of such Stockholder shall execute this
Agreement or a joinder agreeing to become a party to this Agreement. 
 4. No Solicitation of Transactions. Each of the Stockholders,
severally and not jointly, agrees not to directly or indirectly, through any officer, director, representative, agent or otherwise, (a) solicit, initiate or knowingly encourage (including by furnishing information) the submission of, or
participate in any discussions or negotiations regarding, any transaction in violation of the BCA or (b) participate in any discussions or negotiations regarding, or furnish to any person or other entity or “group” within the meaning
of Section 13(d) of the Exchange Act, any information with the intent to, or otherwise cooperate in any way with respect to, or knowingly assist, participate in, facilitate or encourage, any unsolicited proposal that constitutes, or may
reasonably be expected to lead to, an Alternative Transaction in violation of the BCA. Each Stockholder shall, and shall direct his, her or its representatives and agents to, immediately cease and cause to be terminated any discussions or
negotiations with any parties that may be ongoing with respect to any Alternative Transaction (other than the transactions contemplated by the BCA) to the extent required by the BCA. If any Stockholder receives any inquiry or proposal with respect
to an Alternative Transaction, then such Stockholder shall promptly (and in no event later than twenty-four (24) hours after such Stockholder becomes aware of such inquiry or proposal) notify such person in writing that the Company is subject
to an exclusivity agreement with respect to the sale of the Company that prohibits such Stockholder from considering such inquiry or proposal. 

5. Representations and Warranties. Each Stockholder, severally and not jointly, represents and warrants to GigCapital5 as follows: 

(a) The execution, delivery and performance by such Stockholder of this Agreement and the consummation by such Stockholder of the transactions
contemplated hereby do not and will not (i) conflict with or violate any statute, law, ordinance, regulation, rule, code, executive order, injunction, judgment, decree or other order applicable to such Stockholder, (ii) require any
consent, approval or authorization of, declaration, filing or registration with, or notice to, any person or entity, (iii) result in the creation of any encumbrance on any Shares (other than under this Agreement, the BCA and the agreements
contemplated by the BCA) or (iv) if such Stockholder is an entity, conflict with or result in a breach of or constitute a default under any provision of such Stockholder’s governing documents. 

(b) As of the date of this Agreement, such Stockholder owns exclusively of record and has good and valid title to the Shares set forth
opposite the Stockholder’s name on Exhibit A free and clear of any security interest, lien, claim, pledge, proxy, option, right of first refusal, agreement, voting restriction, limitation on disposition, charge, adverse claim
of ownership or use or other encumbrance of any kind and has the sole power to vote and the right, power and authority to sell, transfer and deliver such Shares, other than pursuant and subject to: (i) this Agreement, (ii) applicable
securities laws, and (iii) the Company’s certificate of incorporation 

 
and bylaws. Such Stockholder is not the registered owner of any Shares other than those set forth on Exhibit A. 

(c) Such Stockholder has the power, authority and capacity to execute, deliver and perform this Agreement and that this Agreement has been
duly authorized, executed and delivered by such Stockholder. No person not a signatory to this Agreement (or such signatory’s spouse for purposes of applicable community property laws) has a beneficial interest in or a right to acquire or vote
any of the Shares (other than, if Stockholder is trust, the beneficiary(ies) thereof). 
 6. Termination. This Agreement and the
obligations and liabilities of the Stockholders under this Agreement shall automatically terminate upon the earliest of (a) the Effective Time; (b) the termination of the BCA in accordance with its terms, (c) the effective date of a
written agreement of the parties hereto terminating this Agreement and (d) any material breach by GigCapital5 of the BCA that is not fully cured within the time permitted by the BCA. Upon termination of this Agreement, neither party shall have
any further obligations or liabilities under this Agreement. The representations and warranties contained in this Agreement and in any certificate or other writing delivered pursuant hereto shall not survive the Closing or the termination of this
Agreement. 
 7. Miscellaneous. 

(a) Except as otherwise provided herein, all costs and expenses incurred in connection with this Agreement and the transactions contemplated
hereby shall be paid by the party incurring such costs and expenses, whether or not the transactions contemplated hereby are consummated. 

(b) All notices, requests, claims, demands and other communications hereunder shall be in writing and shall be given (and shall be deemed to
have been duly given upon receipt) by delivery in person, by e-mail or by registered or certified mail (postage prepaid, return receipt requested) to the respective parties at the following addresses
or e-mail addresses (or at such other address or email address for a party as shall be specified in a notice given in accordance with this Section 7(b)): 

If to GigCapital5, to: 
  

			
	 GigCapital5, Inc.
 1731
Embarcadero Road, Suite 200
 Palo Alto, CA 94303

	 Attention:
	  	 Dr. Raluca Dinu, President and Chief Executive Officer

Dr. Avi S. Katz, Executive Chairman of the Board

	 Email:
	  	***; ***

  

			
	with a copy to:
	 DLA Piper LLP (US)
 555 Mission
Street
 Suite 2400
 San Francisco, CA 94105

	Attention:	  	Jeffrey Selman; John Maselli
	Email:	  	jeffrey.selman@us.dlapiper.com; john.maselli@us.dlapiper.com

 If to a Stockholder, to the address or email address set forth for such Stockholder on the signature page
hereof. 
 (c) If any term or other provision of this Agreement is invalid, illegal or incapable of being enforced by any rule of law, or
public policy, all other conditions and provisions of this Agreement shall nevertheless remain in full force and effect so long as the economic or legal substance of the transactions contemplated hereby is not affected in any manner materially
adverse to any party. Upon such determination that any term or other provision is invalid, illegal or incapable of being enforced, the parties hereto shall negotiate in good faith to modify this Agreement so as to effect the original intent of the
parties as closely as possible in a mutually acceptable manner in order that the transactions contemplated hereby be consummated as originally contemplated to the fullest extent possible. 

 (d) This Agreement constitutes the entire agreement among the parties with respect to the
subject matter hereof and supersedes all prior agreements and undertakings, both written and oral, among the parties, or any of them, with respect to the subject matter hereof. This Agreement shall not be assigned (whether pursuant to a merger, by
operation of law or otherwise), by any party without the prior express written consent of the other parties hereto except as permitted by Section 4. 

(e) This Agreement shall be binding upon and inure solely to the benefit of each party hereto, and nothing in this Agreement, express or
implied, is intended to or shall confer upon any other person any right, benefit or remedy of any nature whatsoever under or by reason of this Agreement. No Stockholder shall be liable for the breach by any other Stockholder of this Agreement. 

(f) The parties hereto agree that irreparable damage would occur in the event any provision of this Agreement was not performed in accordance
with the terms hereof and that the parties shall be entitled to specific performance of the terms hereof in addition to any other remedy at law or in equity. 

(g) This Agreement shall be governed by, and construed in accordance with, the laws of the State of Delaware applicable to contracts executed
in and to be performed in that State. All Actions arising out of or relating to this Agreement shall be heard and determined exclusively in any Delaware Chancery Court. The parties hereto hereby (i) submit to the exclusive jurisdiction of the
Delaware Chancery Court for the purpose of any Action arising out of or relating to this Agreement brought by any party hereto, and (ii) irrevocably waive, and agree not to assert by way of motion, defense, or otherwise, in any such Action, any
claim that he, she or it is not subject personally to the jurisdiction of the above-named courts, that his, her or its property is exempt or immune from attachment or execution, that the Action is brought in an inconvenient forum, that the venue of
the Action is improper, or that this Agreement or the transactions contemplated hereunder may not be enforced in or by any of the above-named courts. 

(h) This Agreement may be executed and delivered (including by facsimile or portable document format (pdf) transmission) in counterparts, and
by the different parties hereto in separate counterparts, each of which when executed shall be deemed to be an original but all of which taken together shall constitute one and the same agreement. 

(i) At the request of GigCapital5, in the case of any Stockholder, or at the request of any Stockholder, in the case of GigCapital5, and
without further consideration, each party shall execute and deliver or cause to be executed and delivered such additional documents and instruments and take such further action as may be reasonably necessary to implement the provisions of this
Agreement. 
 (j) Notwithstanding anything to the contrary herein, this Agreement may be amended by adding additional Stockholders of the
Company (“Additional Stockholders”) as parties hereto, upon such Additional Stockholders executing and delivering to GigCapital5, a Joinder to the Stockholder Support Agreement substantially in the form of Exhibit C hereto.
Thereafter, each such Additional Stockholder shall, for all purposes, be a party hereto and all references to a “Stockholder” or the “Stockholders” herein shall thereafter also mean and refer to such Additional Stockholder, and
such Additional Stockholder shall thereafter have the same rights, duties, liabilities and obligations as a Stockholder party hereto on the date hereof. 

(k) This Agreement shall not be effective or binding upon any Stockholder until after such time as the BCA is executed and delivered by the
Company, GigCapital5 and Merger Sub. 
 (l) EACH OF THE PARTIES HERETO HEREBY WAIVES TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW
ANY RIGHT HE, SHE OR IT MAY HAVE TO A TRIAL BY JURY WITH RESPECT TO ANY LITIGATION DIRECTLY OR INDIRECTLY ARISING OUT OF, UNDER OR IN CONNECTION WITH THIS AGREEMENT. EACH OF THE PARTIES HERETO (I) CERTIFIES THAT NO REPRESENTATIVE, AGENT OR
ATTORNEY OF ANY OTHER PARTY HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THAT FOREGOING WAIVER AND (II) ACKNOWLEDGES THAT HE, SHE OR IT AND THE OTHER PARTIES HERETO HAVE
BEEN INDUCED TO ENTER INTO THIS AGREEMENT AND THE TRANSACTIONS CONTEMPLATED HEREBY, AS APPLICABLE, BY, AMONG OTHER THINGS, THE MUTUAL WAIVERS AND CERTIFICATIONS IN THIS SECTION 6(K). 

 

  
 [Signature Pages
Follow] 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	 GIGCAPITAL5, INC.

		
	By:	 	/s/ Dr. Raluca Dinu
	Name:	 	Dr. Raluca Dinu
	 Title:
	 	President and Chief Executive Officer

  
  
  

 
  

  
 Signature page to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	JOHN C. KLOCK, JR. AND CYNTHIA L. KLOCK TRUST DATED 7/27/07
		
	By:	 	 /s/ John C. Klock

			
	Name:	 	John C. Klock
	Title:	 	Trustee
		
	Address:	 	 ***

		
		 	  

		
		 	  

		
	Email:	 	 ***

  
  
  

 
  

  
 Signature page to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	BIOTEX PHARMA INVESTMENTS, LLC
		
	By:	 	 /s/ Robert Kessler

			
	Name:	 	Robert Kessler
	Title:	 	Manager
		
	Address:	 	 ***

		
		 	  

		
		 	  

		
	Email:	 	 ***

  
  
  

 
  

  
 Signature page to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	BIOTEX PHARMA INVESTMENTS II, LLC
		
	By:	 	 /s/ David Gentile

			
	Name:	 	David Gentile
	Title:	 	Manager
		
	Address:	 	 ***

		
		 	  

		
		 	  

		
	Email:	 	 ***

  
  
  

 
  

  
 Signature page to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	KENNETH G. HUNGERFORD TRUST
		
	By:	 	 /s/ Kenneth G. Hungerford

			
	Name:	 	Kenneth G. Hungerford
	Title:	 	Trustee
		
	Address:	 	 ***

		
		 	  

		
		 	  

		
	Email:	 	 ***

  
  
  

 
  

  
 Signature page to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	B.D. WINSTON FAMILY, LTD.
		
	By:	 	 /s/ Benjamin D. Winston

			
	Name:	 	Benjamin D. Winston
	Title:	 	 Managing Member of BD Winston Family

Management, LLC (General Partner of
 B.D. Winston Family,
LTD.)

		
	Address:	 	 ***

		
		 	  

		
		 	  

		
	Email:	 	 ***

  
  
  

 
  

  
 Signature page to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	RICHARD J. AND BARBARA STANLEY
		
	By:	 	 /s/ Richard Stanley

			
	Name:	 	Richard Stanley
	Title:	 	
		
	Address:	 	 ***

		
		 	  

		
		 	  

		
	Email:	 	 ***

  
  
  

 
  

  
 Signature page to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	CVUS VENTURES, LP
		
	By:	 	 /s/ David Gentile

			
	Name:	 	David Gentile
	Title:	 	General Partner
		
	Address:	 	 ***

		
		 	  

		
		 	  

		
	Email:	 	 ***

  
  
  

 
  

  
 Signature page to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	JACHIRIJO HOLDINGS LLC
		
	By:	 	 /s/ David Gentile

			
	Name:	 	David Gentile
	Title:	 	Manager
		
	Address:	 	 ***

		
		 	  

		
		 	  

		
	Email:	 	 ***

  
  
  

 
  

  
 Signature page to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	MIKEL ANN PRICE
		
	By:	 	 /s/ Mikel Ann Price

			
	Name:	 	Mikel Ann Price
	Title:	 	
		
	Address:	 	 ***

		
		 	  

		
		 	  

		
	Email:	 	 ***

  
  
  

 
  

  
 Signature page to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	NASSER PIRSHAFIEY
		
	By:	 	 /s/ Nasser Charles
Pirshafiey

 
			
	Name:	 	Nasser Charles Pirshafiey
	Title:	 	
		
	Address:	 	 ***

		
		 	  

		
		 	  

		
	Email:	 	 ***

  
  
  

 
  

  
 Signature page to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	303 DEVELOPMENT CORP.
		
	By:	 	 /s/ Richard Stanley

			
	Name:	 	Richard Stanley
	Title:	 	President
		
	Address:	 	 ***

		
		 	  

		
		 	  

		
	Email:	 	 ***

  
  
  

 
  

  
 Signature page to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	MARGARET DONIGAN
		
	By:	 	 /s/ Margaret Donigan

			
	Name:	 	Margaret Donigan
	Title:	 	
		
	Address:	 	 ***

		
		 	  

		
		 	  

		
	Email:	 	 ***

  
  
  

 
  

  
 Signature page to
Stockholder Support Agreement 

 EXHIBIT A 

Stockholders of Record – Number of Shares 
  

			
	 Stockholder of Record
	  	Number of Shares
	 John C. Klock, Jr. and Cynthis L. Klock Trust Dated 7/27/07
	  	***
	 Biotex Pharma Investments, LLC
	  	***
	 Biotex Pharma Investments II, LLC
	  	***
	 Kenneth G. Hunderford Trust
	  	***
	 B.D. Winston Family, Ltd.
	  	***
	 Richard J. and Barbara Stanley
	  	***
	 CVUS Ventures, LP
	  	***
	 Jachirijo Holdings LLC
	  	***
	 Mikel Ann Price
	  	***
	 Nasser Pirshafiey
	  	***
	 303 Development Corp.
	  	***
	 Margaret Donigan
	  	***

  
  
  

 
  
  

  
 Exhibit A to
Stockholder Support Agreement 

 EXHIBIT B 

Business Combination Agreement 

See Attached 
  

 
  
  

 
  
  

 

  
 Exhibit B to
Stockholder Support Agreement 

 EXHIBIT C 

JOINDER TO STOCKHOLDER SUPPORT AGREEMENT 

This JOINDER TO STOCKHOLDER SUPPORT AGREEMENT (this “Joinder”) is made and entered into as of [●], by and among each of
the stockholders of QT Imaging, Inc., a Delaware corporation (the “Company”), whose names appear on the signature pages of this Joinder (each, a “Stockholder” and, collectively, the “Stockholders”),
and GigCapital5, Inc., a Delaware corporation (“GigCapital5”). 
 RECITALS 

A.    GigCapital5 and certain stockholders of the Company have entered into a Stockholder Support Agreement dated
December 8, 2022 (as amended, modified, supplemented, extended or restated from time to time, the “Agreement”) in regard to the support of the Merger and the other transactions contemplated by the BCA. Capitalized terms used
herein but not otherwise defined shall have the meanings set forth in the Agreement. 
 B.    Pursuant to the Agreement,
certain stockholders of the Company have agreed, among other things, to (i) vote in favor of the approval and adoption of the BCA and approval of the Merger and all other transactions contemplated by the BCA, and (ii) terminate the
Terminating Rights effective immediately prior to the Closing under the BCA. 
 C.    In order to induce GigCapital5 to
consummate the Merger and other transactions contemplated by the BCA, [the] [each] Additional Stockholder is willing to become a party to the Agreement and be bound by all terms and conditions thereof. 

NOW, THEREFORE, in consideration of the mutual covenants contained herein and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the parties to this Joinder hereby agree as follows: 

1.    Agreement to be bound. [Each] [The] Additional Stockholder hereby: (a) acknowledges that he, she
or it has received and reviewed a complete copy of the Agreement and understands its terms, (b) has had sufficient opportunity to review and to ask questions relating thereto and obtain the advice of his, her or its tax advisors, legal counsel
and accountants and other professional advisors prior to executing this Agreement, and (c) agrees that upon execution of this Joinder, it shall become a “Stockholder” under the Agreement and shall be fully bound by, and subject to,
all of the covenants, duties, obligations terms and conditions of the Agreement as though an original party thereto. 

2.    Governing Law. This Joinder and all acts and transactions pursuant hereto and the rights and
obligations of the parties hereto shall be governed, construed and interpreted in accordance with the laws of the State of Delaware applicable to contracts executed in and to be performed in that State. 

3.    Counterparts. This Joinder may be executed in two or more counterparts, each of which shall be an
original and all of which together shall constitute one instrument. 
 [REMAINDER OF THIS
PAGE INTENTIONALLY LEFT BLANK] 
  
  

  
 Exhibit C to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties hereto have executed this Joinder to Stockholder Support
Agreement as of the date first above written. 
  

			
	[STOCKHOLDER NAME]
		
	By:	 	  

 
			
	Name:	 	
	Title:	 	

 
			
		
	Address:	 	  

		
		 	  

		
		 	  

		
	Email:	 	  

 Securities beneficially owned on the date hereof: 

                 shares of Common
Stock 
  
  
  

 
  

  
 Exhibit C to
Stockholder Support Agreement 

 IN WITNESS WHEREOF, the parties have executed this Joinder to Stockholder Support Agreement
as of the date first written above. 
  

			
	GIGCAPITAL5, INC.
		
	By:	 	  

 
			
	Name:	 	Dr. Raluca Dinu
	Title:	 	President and Chief Executive Officer

  
  
  

 
  
  

 

  
 Exhibit C to
Stockholder Support Agreement 

 STOCKHOLDER SUPPORT AGREEMENT 

SPOUSAL CONSENT 
 I
                            , spouse of
                            , have read and approve the foregoing Stockholder Support Agreement (the
“Agreement”). In consideration of the terms and conditions as set forth in the Agreement, I hereby appoint my spouse as my attorney-in-fact with respect
to the exercise of any rights and obligations under the Agreement, and agree to be bound by the provisions of the Agreement insofar as I may have any rights or obligations in the Agreement under the community property laws or similar laws relating
to marital or community property in effect in the state of our residence as of the date of the Agreement. 
  

	
	
Date                  
                                         
                                         
        

	
	 Signature of
Spouse                                        
                                         
  

	
	 Printed Name of
Spouse

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