Document:

BIOGAN INTERNATIONAL, INC.

                       AMENDED CERTIFICATE OF DESIGNATIONS
                                       OF
                      SERIES A CONVERTIBLE PREFERRED STOCK

             (Pursuant to Section 151 of the General Corporation Law
                            of the State of Delaware)
                     ---------------------------------------

         Gilles LaVerdiere and Robert Montgomery certify that:

         A. They are President and Secretary, respectively, of Biogan
International, Inc., a Delaware corporation (the "Corporation").

         B. Pursuant to authority given by the Corporation's Certificate of
Incorporation, and pursuant to Section 151 of the General Corporation Law of the
State of Delaware, the Board of Directors of the Corporation has duly adopted
the following preambles and resolutions effective as of July 26, 2000:

                  WHEREAS, the Certificate of Incorporation of the Corporation
         provides for a class of shares known as undesignated preferred stock,
         $.001 par value (the "Preferred Stock"), issuable from time to time in
         one or more series;

                  WHEREAS, the Board of Directors of the Corporation is
         authorized to determine or alter the rights, preferences, privileges
         and restrictions granted to or imposed upon any wholly unissued series
         of Preferred Stock, to fix the number of shares constituting any such
         series and to determine the designation thereof, or any of them;

                  WHEREAS, the Board of Directors of the Corporation, by
         unanimous written consent dated February 25, 2000, adopted a resolution
         providing for the creation of a series of the Corporation's Preferred
         Stock designated as "Series A Convertible Preferred Stock," and
         pursuant to which the Corporation filed with the Delaware Secretary of
         State on March 13, 2000 a Statement of Designations of the Preferences
         of the Series of the Preferred Stock of Biogan International, Inc. to
         be designated Series A Convertible Preferred Stock;

                  WHEREAS, no shares of Series A Convertible Preferred Stock
         have been issued;

                  WHEREAS, the Board of Directors of the Corporation desires,
         pursuant to the authority described above, to determine, fix and alter
         certain of the rights, preferences, privileges and restrictions of the
         Series A Convertible Preferred Stock.

<PAGE>

                  NOW, THEREFORE, BE IT RESOLVED, that the Board of Directors
         hereby determines, fixes, alters and amends the designation of, and the
         rights, preferences, privileges and restrictions relating to, the
         Series A Convertible Preferred Stock as follows:

                      SERIES A CONVERTIBLE PREFERRED STOCK

         1. DESIGNATION AND AMOUNT. The series of Preferred Stock designated as
Series A Convertible Preferred Stock ("Series A Preferred") shall consist of
31,300 shares.

         2. DIVIDENDS. The holders of Series A Preferred shall not be entitled
to receive any dividends.

         3. LIQUIDATION PREFERENCE. The holders of Series A Preferred shall have
a liquidation preference as follows:

                  3.1 RELATIVE PREFERENCE. In the event of any liquidation,
         dissolution or winding up of the Corporation, either voluntary or
         involuntary, the holders of the Series A Preferred shall be entitled to
         receive, out of the assets of the Corporation available for
         distribution to stockholders, prior and in preference to any
         distribution of any assets of the Corporation to the holders of Common
         Stock and of any other class or series of equity securities ranking, as
         to liquidation rights, junior to the Series A Preferred, for each share
         of Series A Preferred held at the time of such liquidation, dissolution
         or winding up, an amount equal to $1.00 plus an amount equal to the
         amount that would have been received by such holder had such holder
         converted to Common Stock immediately prior to such voluntary or
         involuntary liquidation, dissolution or winding up of the Corporation.
         If, upon occurrence of such event, the assets and funds thus
         distributed the holders of the Series A Preferred are insufficient to
         permit the payment to the holders of the Series A Preferred the full
         preferential amounts to which they are entitled pursuant to this
         Section 3.1, then the entire assets and funds of the Corporation
         legally available for distribution shall be distributed ratably among
         the holders of the Series A Preferred and any other class or series of
         capital stock of the Corporation ranking on a parity with the shares of
         the Series A Preferred in proportion to the full liquidation preference
         to which such holder is entitled.

                  3.2 DISTRIBUTION. After payment has been made to the holders
         of the Series A Preferred of the respective amounts to which they shall
         be entitled as provided in Section 3.1 above, the holders of such
         shares shall not have any right or claim to any of the remaining assets
         of the Corporation.

         4. CONVERSION. The holders of the Series A Preferred shall have
conversion rights as follows:

                  4.1 RIGHT TO CONVERT. Each share of Series A Preferred shall
         be convertible, at the option of the holder thereof, at any time after
         September 30, 2000, for such number of fully paid and nonassessable
         shares of Common Stock of the Corporation as is determined by
         multiplying the number of shares of Series A Preferred being converted
         by 12,000. Immediately following such conversion, the rights of the
         holders of converted Series A Preferred shall cease and the persons
         entitled to receive the Common Stock upon the conversion of Series A
         Preferred shall be treated for all purposes as having become the owners
         of such Common Stock, subject to the rights provided herein.

                                      -2-
<PAGE>

                  4.2 MECHANICS OF CONVERSION. To convert Series A Preferred
         into Common Stock, the holder shall surrender the certificate or
         certificates therefor, duly endorsed, at the office of the Corporation
         or of any transfer agent for the Series A Preferred, and shall give
         written notice to the Corporation at such office that he elects to
         convert the same. Such notice shall also state the number of shares of
         Series A Preferred to be converted and the name or names in which such
         holder wishes the certificate or certificates for Common Stock to be
         issued. The Corporation shall, as soon as practicable thereafter, issue
         and deliver at such office to such holder of Series A Preferred, a
         certificate or certificates for the number of shares of Common Stock to
         which he shall be entitled as provided herein. Such conversion will be
         deemed to have been made immediately prior to the close of business on
         the date of such surrender of the shares of Series A Preferred to be
         converted, and the person or persons entitled to receive the shares of
         Common Stock issuable upon such conversion shall be treated for all
         purposes as the record holder or holders of such shares of Common Stock
         on such date.

                  4.3 STOCK SPLITS; DIVIDENDS; ADJUSTMENTS. If the Corporation,
         at any time while the Series A Preferred are outstanding, shall pay a
         stock dividend or otherwise make a distribution or distributions on the
         Common Stock, or the outstanding shares of Common Stock are subdivided,
         combined or consolidated, by reclassification, stock split or
         otherwise, into a greater or lesser number of shares of Common Stock,
         the number of shares into which such Series A Preferred is convertible
         shall, concurrently with the effectiveness of such dividend,
         subdivision, combination or consolidation, be proportionately adjusted.

                  4.4 NO IMPAIRMENT. The Corporation will not, by amendment
         hereof or of its Certificate of Incorporation, or through any
         reorganization, transfer of assets, consolidation, merger, dissolution,
         issue or sale of securities or any other voluntary action, avoid or
         seek to avoid the observance or performance of any of the terms to be
         observed or performed hereunder by the Corporation, but will at all
         times in good faith assist in the carrying out of all the provisions of
         this Section 4 and in the taking of all such action as may be necessary
         or appropriate in order to protect the conversion rights of the holders
         of the Series A Preferred against impairment.

                  4.5 NOTICE OF RECORD DATE. In the event of any taking by the
         Corporation of a record date of the holders of any class of securities
         for the purpose of determining the holders thereof who are entitled to
         receive any dividend or other distribution, any security or right
         convertible into or entitling the holder thereof to receive additional
         shares of Common Stock, or any right to subscribe for, purchase or
         otherwise acquire any shares of stock of any class or any other
         securities or property, or to receive any other right, the Corporation
         shall deliver to each holder of Series A Preferred, at least 20 days
         prior to the date specified therein, a notice specifying the date on
         which any such record is to be taken for the purpose of such dividend,
         distribution, security or right and the amount and character of such
         dividend, distribution, security or right.

                                      -3-
<PAGE>

                  4.6 FRACTIONAL SHARES. No fractional shares shall be issued
         upon the conversion of any Series A Preferred. All shares of Common
         Stock (including fractions thereof) issuable upon conversion of more
         than one share of Series A Preferred by a holder thereof and all Series
         A Preferred issuable upon the purchase thereof shall be aggregated for
         purposes of determining whether the conversion and/or purchase would
         result in the issuance of any fractional share. If, after the
         aforementioned aggregation, the conversion and/or purchase would result
         in the issuance of a fraction of a share of Common Stock, the
         Corporation shall, in lieu of issuing any fractional share, either
         round up the number of shares to the next highest whole number or, at
         the Corporation's option, pay the holder otherwise entitled to such
         fraction a sum in cash equal to the fair market value of such fraction
         on the Conversion Date (as determined in good faith by the Board of
         Directors of the Corporation).

                  4.7 REORGANIZATION OR MERGER. In case of any reorganization or
         any reclassification of the capital stock of the Corporation or any
         consolidation or merger of the Corporation with or into any other
         corporation or corporations or a sale or transfer of all or
         substantially all of the assets of the Corporation to any other person,
         then, as part of such reorganization, consolidation, merger, or
         transfer if the holders of shares of Common Stock receive any
         securities as part or all of the consideration for such reorganization,
         consolidation, merger or sale, then it shall be a condition precedent
         of any such event or transaction that provision shall be made such that
         each share of Series A Preferred shall thereafter be convertible into
         such new securities at a conversion price and pricing formula which
         places the holders of Series A Preferred in an economically equivalent
         position as they would have been if not for such event. In addition to
         the foregoing, if the holders of shares of Common Stock receive any
         other property or cash as part or all of the consideration for such
         reorganization, consolidation, merger or sale, then such distribution
         shall be treated to the extent thereof as a distribution under Section
         4.3 above and such Section shall also apply to such distribution.

         5. SPECIFIC ENFORCEMENT. The Corporation agrees that irreparable damage
would occur in the event that any of the provisions hereof were not performed in
accordance with their specific terms or were otherwise breached. It is
accordingly agreed that the holders of Series A Preferred shall be entitled to
specific performance, injunctive relief or other equitable remedies to prevent
or cure breaches of the provisions hereof and to enforce specifically the terms
and provisions hereof, this being in addition to any other remedy to which any
of them may be entitled under agreement, at law or in equity.

         6. VOTING RIGHTS. Except as otherwise required by law, the holders of
Series A Preferred shall be entitled to notice of any stockholders' meeting and
to vote with the Common Stock and any other series of Preferred Stock having the
right to vote generally as a single class upon any matter submitted to the
stockholders for a vote, as follows: (i) each holder of Series A Preferred shall
have one vote for each full share of Common Stock into which its respective
shares of Series A Preferred would be convertible on the record date for the
vote, and (ii) the holders of Common Stock shall have one vote per share of
Common Stock.

                                      -4-
<PAGE>

         7. NOTICES. The Corporation shall distribute to the holders of Series A
Preferred copies of all notices, materials, annual and quarterly reports, proxy
statements, information statements and any other documents distributed generally
to the holders of shares of Common Stock of the Corporation, at such times and
by such method as such documents are distributed to such holders of such Common
Stock.

         8. REPLACEMENT CERTIFICATES. The certificate(s) representing the Series
A Preferred held by any holder of Series A Preferred may be exchanged by such
holder at any time and from time to time for certificates with different
denominations representing an equal aggregate number of Series A Preferred, as
reasonably requested by such holder, upon surrendering the same. No service
charge will be made for such registration or transfer or exchange. Upon receipt
by the Corporation of evidence reasonably satisfactory to it of the loss, theft,
destruction or mutilation of any stock certificate representing the Series A
Preferred and, in the case of loss, theft or destruction, of indemnity
reasonably satisfactory to it, or upon surrender and cancellation of such stock
certificate if mutilated, the Corporation will make and deliver a new stock
certificate of like tenor and dated as of such cancellation at no charge to the
holder.

         9. ATTORNEYS' FEES. In connection with enforcement by a holder of
Series A Preferred of any obligation of the Corporation hereunder, the
prevailing party shall be entitled to recovery of reasonable attorneys' fees and
expenses incurred.

         10. NO REISSUANCE. No Series A Preferred acquired by the Corporation by
reason of redemption, purchase, conversion or otherwise shall be reissued.

         11. SEVERABILITY OF PROVISIONS. If any right, preference or limitation
of the Series A Preferred set forth herein (as may be amended from time to time)
is invalid, unlawful or incapable of being enforced by reason of any rule or law
or public policy, all other rights, preferences and limitations set forth
herein, which can be given effect without the invalid, unlawful or unenforceable
right, preference or limitation shall nevertheless remain in full force and
effect, and no right, preference or limitation herein set forth be deemed
dependent upon any such other right, preference or limitation unless so
expressed herein.

         12. LIMITATIONS. Except as may otherwise be required by law, the Series
A Preferred shall not have any powers, preference or relative participating,
optional or other special rights other than those specifically set forth herein
(as may be amended from time to time).

         IN WITNESS WHEREOF, this Amended Certificate of Designations of Series
A Convertible Preferred Stock has been executed by the undersigned duly
authorized officers of the Corporation on July 31, 2000.

                                 Biogan International, Inc.

                                 By:      /S/ GILLES LaVERDIERE
                                    -------------------------------------
                                        Gilles LaVerdiere, President

                                 By:      /S/ ROBERT C. MONTGOMERY
                                    -------------------------------------
                                         Robert C. Montgomery, Secretary

                                      -5-THIS WARRANT AND THE STOCK ISSUABLE UPON THE EXERCISE HEREOF HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), AND CAN BE
TRANSFERRED ONLY IN COMPLIANCE WITH THE ACT AND APPLICABLE STATE SECURITIES
LAWS. THIS WARRANT AND SUCH SECURITIES MAY NOT BE SOLD, TRANSFERRED OR ASSIGNED
IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT, UNLESS, IN THE OPINION OF
COUNSEL FOR THE COMPANY OR COUNSEL FOR THE REGISTERED HOLDER (WHICH SHALL BE IN
FORM AND FROM SUCH COUNSEL AS SHALL BE REASONABLY SATISFACTORY TO THE COMPANY),
SUCH REGISTRATION IS NOT THEN REQUIRED.

                            BIOGAN INTERNATIONAL INC.
                          COMMON STOCK PURCHASE WARRANT

         1. ISSUANCE. In consideration of good and valuable consideration, the
receipt of which is hereby acknowledged by BIOGAN INTERNATIONAL, INC., a
Delaware corporation (the "Company"), CALP II, LLC, a Bermuda limited liability
company, or registered assigns (the "Holder") is hereby granted the right to
purchase at any time until 5:00 P.M., Pacific Coast time, on February 28, 2003
(the "Expiration Date"), Four Hundred Eight Hundred Thousand (480,000) fully
paid and nonassessable shares of the Company's Common Stock, par value $0.001
per share (the "Common Stock") at an exercise price of $0.60 per share (the
"Exercise Price") subject to further adjustment as set forth in Section 6
hereof.

         2. EXERCISE OF WARRANTS. This Warrant is exercisable in whole or in
part for whole shares of the Company's Common Stock at the Exercise Price per
share of Common Stock payable hereunder, payable in cash or by certified or
official bank check. In lieu of paying cash to exercise this Warrant, the Holder
may, by designating a "cashless" exercise on the Notice of Exercise Form,
acquire a number of whole shares of the Company's Common Stock equal to (a) the
difference between (i) the Market Value of the Company's Common Stock and (ii)
the Exercise Price, multiplied by (b) the number of shares of Common Stock
purchasable under the portion of the Warrant tendered to the Company, divided by
(c) the Market Value of the Company's Common Stock. Upon surrender of this
Warrant Certificate with the annexed Notice of Exercise Form duly executed,
together with payment of the Exercise Price for the shares of Common Stock
purchased, the Holder shall be entitled to receive a certificate or certificates
for the shares of Common Stock so purchased. For the purposes of this Section 2,
"Market Value" shall be an amount equal to the average closing bid price of a
share of Common Stock for the five (5) business days immediately preceding the
Company's receipt of the Notice of Exercise Form duly executed.

         3. RESERVATION OF SHARES. The Company hereby agrees that at all times
during the term of this Warrant there shall be reserved for issuance upon
exercise of this Warrant such number of shares of its Common Stock as shall be
required for issuance upon exercise of this Warrant (the "Warrant Shares").

<PAGE>

         4. MUTILATION OR LOSS OF WARRANT. Upon receipt by the Company of
evidence satisfactory to it of the loss, theft, destruction or mutilation of
this Warrant, and (in the case of loss, theft or destruction) receipt of
reasonably satisfactory indemnification, and (in the case of mutilation) upon
surrender and cancellation of this Warrant, the Company will execute and deliver
a new Warrant of like tenor and date and any such lost, stolen, destroyed or
mutilated Warrant shall thereupon become void.

         5. RIGHTS OF THE HOLDER. The Holder shall not, by virtue hereof, be
entitled to any rights of a stockholder in the Company, either at law or equity,
and the rights of the Holder are limited to those expressed in this Warrant and
are not enforceable against the Company except to the extent set forth herein.

         6. ADJUSTMENTS TO EXERCISE TERMS.

         If the Company at any time prior to the full execution of this Warrant
shall, by subdivision, combination, merger, spin-off, re-classification or like
capital adjustment of the securities, change any of the securities to which
purchase rights under this Warrant exist into the same or different number of
securities of any class or classes, this Warrant shall thereafter entitle the
Holder to acquire such number and kind of securities as would have been issuable
as a result of such change with respect to the securities acquirable immediately
prior to such transaction. If shares of the securities acquirable upon exercise
of this Warrant are subdivided into a greater number of securities, including
any stock dividend, or if such securities are combined into a lesser number of
securities, then the purchase price for the securities acquirable upon exercise
of this Warrant and the securities acquirable pursuant to this Warrant shall be
proportionately and equitably adjusted.

         7. TRANSFER TO COMPLY WITH THE SECURITIES ACT; REGISTRATION RIGHTS.

         (a) This Warrant has not been registered under the Securities Act of
1933, as amended, (the "Act") and has been issued to the Holder for investment
and not with a view to the distribution of either the Warrant or the Warrant
Shares. Neither this Warrant nor any of the Warrant Shares or any other security
issued or issuable upon exercise of this Warrant may be sold, transferred,
pledged or hypothecated in the absence of an effective registration statement
under the Act and applicable state securities laws relating to such security,
unless in the opinion of counsel satisfactory to the Company, such registrations
are not required under the Act. Each certificate for the Warrant, the Warrant
Shares and any other security issued or issuable upon exercise of this Warrant
shall contain a legend on the face thereof, in form and substance satisfactory
to counsel for the Company, setting forth the restrictions on transfer contained
in this Section.

         (b) The Company agrees to file a registration statement, which shall
include the Warrant Shares, on Form SB-2 or another available form (the
"Registration Statement"), pursuant to the Act, pursuant to a Registration
Rights Agreement between the Company and Holder dated as of the date hereof (the
"Registration Rights Agreement").

                                       2
<PAGE>

         8. NOTICES. Any notice or other communication required or permitted
hereunder shall be in writing and shall be delivered personally, telegraphed,
telexed, sent by facsimile transmission or sent by certified, registered or
express mail, postage pre-paid. Any such notice shall be deemed given when so
delivered personally, telegraphed, telexed or sent by facsimile transmission,
or, if mailed, two days after the date of deposit in the United States mails, as
follows:

                  (i)      if the to Company, to:

                           BIOGAN INTERNATIONAL, INC.
                           813 Beriault, Suite 203, Longueuil
                           Quebec, Canada J4G 1X7
                           ATTN: CEO
                           Telecopier No.: (450) 651-8049
                           Telephone No.: (450) 651-6701

                  (ii)     if to the Holder, to:

                           c/o Thomson Kernaghan & Co.
                           365 Bay Street, Suite 1000, 10th Fl.
                           Toronto, Ontario M5H 2V2
                           Telephone No.: (416) 860-4160
                           Telecopier No.: (416) 860-8313

Any party may be notice given in accordance with this Section to the other
parties designate another address or person for receipt of notices hereunder.

         9. SUPPLEMENTS AND AMENDMENTS; WHOLE AGREEMENT. This Warrant may be
amended or supplemented only by an instrument in writing signed by the parties
hereto. This Warrant contains the full understanding of the parties hereto with
respect to the subject matter hereof and thereof and there are no
representations, warranties, agreements or understandings other than expressly
contained herein and therein.

         10. GOVERNING LAW. This Warrant shall be deemed to be a contract made
under the laws of the State of California and for all purposes shall be governed
by and construed in accordance with the laws of such State applicable to
contracts to be made and performed entirely within such State.

         11. DESCRIPTIVE HEADINGS. Descriptive headings of the several Sections
of this Warrant are inserted for convenience only and shall not control or
affect the meaning or construction of any of the provisions hereof.

                                       3
<PAGE>

         IN WITNESS WHEREOF, the parties hereto have executed this Warrant as of
the ___th day of March, 2000.

                              BIOGAN INTERNATIONAL, INC., a Delaware corporation

                              By: /S/ GILLES LaVERDIERE
                                 ------------------------------------
                                      Name:  Gilles LaVerdiere
                                      Title: President

Attest:

------------------------------------
Name:
Title:

                                       4

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