Document:

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                                                                     Exhibit 4.7

                    SHARE TRANSFER AND RESTRICTION AGREEMENT

                  Share Transfer and Restriction Agreement (this "AGREEMENT"),
dated as of October 6, 2000, by and among Athersys, Inc., a Delaware corporation
(the "COMPANY"), Biotech 3 Investment L.L.C., a Delaware limited liability
company ("BIOTECH"), Mark N. Lampert ("LAMPERT") and Michael Sacks ("SACKS").

                                    RECITALS:

                  WHEREAS, the Company and Biotech are parties to that certain
Amended and Restated Stockholders' Agreement, dated as of April 28, 2000, as it
may be amended from time to time (the "STOCKHOLDERS' AGREEMENT"), by and among
the Company, Biotech and certain other holders (collectively, the "HOLDERS") of
capital stock of the Company;

                  WHEREAS, Biotech desires to sell, and Van Wagoner Funds and
its affiliates ("VAN WAGONER") desires to purchase shares of the Company's
capital stock pursuant to the terms and conditions set forth in that certain
Stock Purchase Agreement, dated as of October 6, 2000 (the "BIOTECH AGREEMENT"),
by and between Biotech and Van Wagoner;

                  WHEREAS, Company currently intends to file a registration
statement on Form S-1 with the Securities and Exchange Commission;

                  WHEREAS, in furtherance of the transactions contemplated by
the Biotech Agreement, the Company has agreed to amend the Stockholders'
Agreement, subject to necessary approval of the parties thereto; and

                  WHEREAS, Biotech, Lampert and Sacks have agreed to enter into
this Agreement in consideration for the Company agreeing to amend the
Stockholders' Agreement in order to permit the transactions contemplated by the
Biotech Agreement to be consummated without first giving the notice required by
Section 3 of the Stockholders' Agreement and use its reasonable best efforts to
obtain the requisite consent of the Holders to such amendment.

                                   AGREEMENTS:

                  NOW, THEREFORE, the parties, intending to be legally bound,
agree as follows:

                  SECTION 1. LOCKUP AGREEMENT RELATING TO INITIAL PUBLIC
OFFERING. The Company represents and warrants that the IPO Lockup Agreement (as
defined below) is identical to the lockup agreements that have been or will be
executed by all directors, officers and those persons and entities that, as of
the date of this Agreement, hold more than one percent of the outstanding shares
of Common Stock (as defined below) on a fully diluted basis (collectively,
"RESTRICTED PARTIES"). Each of Biotech, Lampert and Sacks, severally and not
jointly, hereby represents and warrants to the Company that he or it (i) has
duly executed a lockup agreement in the form attached hereto as ANNEX A (the
"IPO LOCKUP AGREEMENT") in connection with the

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initial Public Offering (as defined in Section 6) (the "IPO") of the Company's
Common Stock, par value $.01 per share (the "COMMON Stock"), (ii) has delivered
his or its executed IPO Lockup Agreement to Pillsbury Madison & Sutro LLP, as
escrow agent ("PMS"), and (iii) has irrevocably instructed PMS to hold the
executed IPO Lockup Agreement in escrow until such time as the conditions set
forth in Section 11.1 of the Biotech Agreement have been satisfied (the "RELEASE
EVENT"), and to immediately deliver by telecopy his or its executed IPO Lockup
Agreement to Credit Suisse First Boston Corporation, as representative of the
several underwriters for the IPO ("CSFB"), 11 Madison Avenue, New York, New York
10010-3629, Attention: Vassili Mechtcheriakov, Telecopy No. (212) 325-8000, upon
receipt by PMS of a written notice from the Company that the Release Event has
occurred.

                  SECTION 2. ADDITIONAL RESTRICTIONS RELATING TO INITIAL PUBLIC
OFFERING. (a) Except as expressly provided by or contemplated under the Biotech
Agreement, from the date of this Agreement until the close of business on the
180th day after the date set forth on the final prospectus used to sell shares
of Common Stock in the IPO, so long as such date is on or before March 31, 2001
(the "PUBLIC OFFERING DATE"), none of Biotech, Lampert or Sacks may offer, sell,
contract to sell, pledge or otherwise dispose of, directly or indirectly, any
Securities (as defined in the IPO Lockup Agreement), or enter into any
transaction that would have the same effect, or enter into any swap, hedge or
other arrangement that transfers, in whole or in part, any of the economic
consequences of ownership of the Securities, to any person or entity, including
without limitation any member of Biotech or any other affiliate of any of
Biotech, Lampert or Sacks, whether any such aforementioned transaction is to be
settled by delivery of the Securities, in cash or otherwise, or publicly
disclose the intention to make any such offer, sale, pledge or disposition, or
to enter into any such transaction, swap, hedge, or other arrangement, without,
in each case, the prior written consent of CSFB. The transactions described in
this Section 2(a) are collectively referred to herein as "TRANSFERS."

                  (b) Since the respective dates of acquisition of their shares
of capital stock of the Company, none of Biotech, Lampert or Sacks have
Transferred any shares of capital stock, other than Biotech's Transfer of
options to purchase shares of the Company's convertible preferred stock to Ohio
Innovation Fund I, L.P. in June 1998.

                  SECTION 3. RESTRICTIONS ON PUBLIC SALES AND DISTRIBUTIONS
FOLLOWING THE INITIAL PUBLIC OFFERING. From the close of business on the 180th
day following the Public Offering Date until the close of business on the 360th
day following the Public Offering Date, none of Biotech, Lampert, Sacks or any
of their Permitted Transferees (as defined in Section 4) shall, individually or
collectively, effect any Transfer of shares of Common Stock in an amount that
exceeds, in the aggregate, the lesser of (i) 1.2 million shares of Common Stock
(as adjusted for any stock split, subdivision, split-up, combination or
reclassification of the Common Stock, or any stock dividend payable in shares of
Common Stock), and (ii) a number of shares of Common Stock yielding gross
proceeds of $30.0 million in the aggregate, in either case other than a Transfer
expressly contemplated by Section 4, the Biotech Agreement or a sale pursuant to
Sections 2 or 3 of the Amended and Restated Registration Rights Agreement, dated
as of April 28, 2000, as it may be further amended from time to time (the
"REGISTRATION RIGHTS AGREEMENT"), between the Company, Biotech, and certain
other holders of the capital stock of the Company. If any shares of Common Stock
are Transferred to a member of Biotech (or by a member of Biotech to an

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investor in such a member) pursuant to this Section 3, as a condition of such
Transfer, the transferee shall be required to execute a joinder agreement and to
become a party to and subject to the provisions of this Agreement.

                  SECTION 4. RESTRICTIONS ON OTHER TRANSFERS FOLLOWING THE
INITIAL PUBLIC OFFERING. From the 181st day following the Public Offering Date
until the 360th day following the Public Offering Date, any of Biotech, Lampert,
Sacks or their respective Permitted Transferees (as defined below) may Transfer
shares of Common Stock to any person or entity that is a member of Biotech (or,
in the case of a Transfer by a Permitted Transferee, a member of Biotech or an
investor in such a member), so long as upon any such Transfer of shares of
Common Stock, as a condition to such Transfer, the transferee shall be required
to execute a joinder agreement to become a party to and subject to the
provisions of this Agreement (such transferees, "PERMITTED TRANSFEREES").

                  SECTION 5. EFFECT; COOPERATION. Any Transfer of shares of
Common Stock that is not made strictly in accordance with Section 3 or Section 4
shall be null and void, and neither the Company nor its transfer agent, if any,
will recognize any such Transfer or the purported transferee as a holder of
shares of Common Stock. The Company shall reasonably cooperate with Biotech,
Lampert, Sacks and their respective Permitted Transferees to facilitate any
Transfer of shares of Common Stock held by any of Biotech, Lampert, Sacks or
their respective Permitted Transferees that is in accordance with the provisions
of the Stockholders' Agreement and this Agreement, including, without
limitation, facilitating sales and other dispositions under Rule 144 promulgated
under the Securities Act or otherwise.

                  SECTION 6. EXECUTION OF LOCKUP AGREEMENTS. Until the close of
business, New York City time, on December 31, 2001, in connection with any
underwritten public offering (a "PUBLIC OFFERING") of the Common Stock, each of
Biotech, Lampert, Sacks and their respective Permitted Transferees shall execute
the form of "lockup" agreement ("LOCKUP AGREEMENT") for a period not to exceed
180 days after the effective date of the Public Offering that the managing
underwriter(s) for the Public Offering requires the Restricted Parties to
execute, and shall deliver the executed Lockup Agreement to the Company and/or
the managing underwriter(s) on or before the date that all other Restricted
Parties are requested to deliver Lockup Agreements to the Company and/or the
managing underwriter(s), PROVIDED, that all other Restricted Parties enter into
the same form of Lockup Agreement with respect to such Public Offering, and
PROVIDED, FURTHER, that the Company and the managing underwriter(s) for the
Public Offering shall agree not to release any other Restricted Party from the
Lockup Agreement prior to the release of Biotech, Lampert, Sacks, and their
Permitted Transferees and PROVIDED, FURTHER, that this Section 6 shall not
require any of Biotech, Lampert, Sacks or any of their Permitted Transferees to
execute and deliver Lockup Agreements in connection with more than two Public
Offerings. A Lockup Agreement will not constitute one of the two Lockup
Agreements required to be executed pursuant to this Section 6 until the Public
Offering to which it relates has closed.

                  SECTION 7. RESCISSION OF EXERCISE OF PIGGYBACK REGISTRATION
RIGHTS. Effective upon the Release Event, Biotech rescinds in all respects its
letter to the Company dated September 29, 2000 (the "EXERCISE NOTICE"), pursuant
to which Biotech gave notice of its intention to exercise its piggyback
registration rights pursuant to the applicable provisions of the

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Registration Rights Agreement, and agrees that upon the Release Event the
Exercise Notice shall be null and void and of no further force or effect.

                  SECTION 8. REFERENCE ON CERTIFICATES. Upon consummation of the
transactions contemplated by the Biotech Agreement, in addition to any other
legends required by the Stockholders' Agreement or the Registration Rights
Agreement, each certificate representing shares of capital stock of the Company
now or hereafter held by any of Biotech, Lampert, Sacks or any of their
respective Permitted Transferees shall contain a legend in substantially the
following form:

                  THE TRANSFER OF THE SHARES OF STOCK REPRESENTED BY THIS
         CERTIFICATE IS RESTRICTED UNDER THE TERMS OF A SHARE TRANSFER AND
         RESTRICTION AGREEMENT, DATED AS OF OCTOBER 6, 2000, AS IT MAY BE
         AMENDED FROM TIME TO TIME, BY AND AMONG ATHERSYS, INC. AND CERTAIN
         HOLDERS OF ITS SECURITIES, A COPY OF WHICH AGREEMENT WILL BE MAILED TO
         THE HOLDER HEREOF WITHOUT CHARGE WITHIN FIVE DAYS AFTER RECEIPT BY
         ATHERSYS, INC. OF WRITTEN REQUEST THEREFOR.

                  SECTION 9. TERMINATION. This Agreement shall terminate and be
null and void and of no further force and effect if the Biotech Agreement is
terminated without the Closing (as defined in the Biotech Agreement) having
occurred, or if the parties to this Agreement mutually agree that the Release
Event cannot reasonably be expected to occur, which agreement shall not be
unreasonably withheld.

                  SECTION 10. MULTIPLE COUNTERPARTS. This Agreement may be
executed in two or more counterparts, each of which constitutes an original, and
all of which taken together shall constitute one and the same Agreement.

                  SECTION 11. GOVERNING LAW. This Agreement shall be governed by
the laws of the State of Delaware, without reference to its conflict of law
principles.

                  SECTION 12. SEVERABILITY. If any section, paragraph,
subparagraph or provision of this Agreement is found for any reason whatsoever
to be invalid or inoperative, that section, paragraph, subparagraph or provision
will be deemed severable and will not affect the force and validity of any other
provision of this Agreement. If any section, paragraph, subparagraph or
provision of this Agreement is determined by a court to be invalid or
inoperative, the parties agree and it is their desire that such court substitute
a reasonable judicially enforceable provision in place of the invalid or
inoperative provision and that as so modified the provision will be as fully
enforceable as if set forth in this Agreement by the parties themselves in the
modified form.

                  SECTION 13. HEADINGS; REFERENCES. The headings and subheadings
in this Agreement are for convenience of reference only and are not part of this
Agreement and will not be used in construing it. References to Sections and
Annexes in this Agreement are references to Sections of and Annexes to this
Agreement unless the context clearly requires otherwise.

                  SECTION 14. REMEDIES. Any person or entity having rights under
any provision of this Agreement will be entitled to enforce such rights
specifically to recover damages caused

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by reason of any breach of any provision of this Agreement and to exercise all
other rights granted by law. The parties hereto agree and acknowledge that money
damages may not be an adequate remedy for any breach of the provisions of this
Agreement and that any party may in its sole discretion apply to any court of
law or equity of competent jurisdiction for specific performance and for other
injunctive relief in order to enforce or prevent violation of the provisions of
this Agreement.

                  SECTION 15. ATTORNEYS' FEES. If any action at law or in equity
(including arbitration) is necessary to enforce or interpret the terms of this
Agreement, the prevailing party shall be entitled to reasonable attorneys' fees,
costs and necessary disbursements in addition to any other relief to which such
party is entitled as determined by such court, equity or arbitration proceeding.

                  SECTION 16. ENTIRE AGREEMENT; CONFLICTS. This Agreement, the
Stockholders' Agreement and the Registration Rights Agreement together
constitute the entire agreement of the parties and there are no other
agreements, written or oral, between the parties related to the subject matter
of this Agreement. In the event of a conflict between the provisions of this
Agreement and the Stockholders' Agreement, the terms of this Agreement shall
prevail. Nothing herein is intended to modify or amend the Registration Rights
Agreement.

                         [Signatures on following page]

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         IN WITNESS WHEREOF, the parties have executed this Share Transfer and
Restriction Agreement as of the date first above written.

                                 ATHERSYS, INC.

                                 By:  /s/ Gil Van Bokkelen
                                      ---------------------------------
                                      Gil Van Bokkelen
                                      President and Chief Executive Officer

                                 BIOTECH 3 INVESTMENT L.L.C.
                                 By:  BVF Partners L.P., its Manager
                                 By:  BVF Inc., its general partner

                                 By:  /s/ Mark N. Lampert
                                      ---------------------------------
                                      Mark N. Lampert
                                      President

                                 /s/ Mark N. Lampert
                                 --------------------------------------
                                 Mark N. Lampert

                                 /s/ Michael Sacks
                                 --------------------------------------
                                 Michael Sacks<PAGE>   1
                                                                    Exhibit 10.6

                               1995 INCENTIVE PLAN
                                       OF
                                 ATHERSYS, INC.

         1. PURPOSE OF THE PLAN. This 1995 Incentive Plan of Athersys, Inc.
adopted as of the 1st day of November, 1995, is intended to encourage officers
and other key employees, consultants and directors of the Company and its
Subsidiaries to acquire or increase their ownership of common stock of the
Company on reasonable terms. The opportunity so provided is intended to foster
in participants a strong incentive to put forth maximum effort for the continued
success and growth of the Company and its Subsidiaries, to aid in retaining
individuals who put forth such efforts, and to assist in attracting the best
available individuals to the Company and its Subsidiaries in the future.

         2. DEFINITIONS. When used herein, the following terms shall have the
meaning set forth below:

                  2.1 "Award" means an Option, a Restricted Stock Award or a
         Stock Bonus Award.

                  2.2 "Award Agreement" means a written agreement in such form
         as may be, from time to time, hereafter approved by the Board, or the
         Committee if one has been appointed, which shall be duly executed by
         the Company and the Participant and which shall set forth the terms and
         conditions of an Award under the Plan.

                  2.3 "Board" means the Board of Directors of Athersys, Inc.

                  2.4 "Code" means the Internal Revenue Code of 1986, as in
         effect at the time of reference, or any successor revenue code which
         may hereafter be adopted in lieu thereof, and reference to any specific
         provisions of the Code shall refer to the corresponding provisions of
         the Code as it may hereafter be amended or replaced.

                  2.5 "Committee" means the Stock Option Committee of the Board
         or any other committee appointed by the Board which is invested by the
         Board with responsibility for the

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         administration of the Plan and whose members meet the requirements for
         eligibility to serve to the extent required by Rule 16b-3 (when and if
         such Rule is applicable to the Company) and the Plan.

                  2.6 "Company" means Athersys, Inc.

                  2.7 "Exchange Act" means the Securities Exchange Act of 1934,
         as in effect at the time of reference, or any successor law which may
         hereafter be adopted in lieu thereof, and any reference to any specific
         provisions of the Exchange Act shall refer to the corresponding
         provisions of the Exchange Act as it may hereafter be amended or
         replaced.

                  2.8 "Fair Market Value" means with respect to the Shares, the
         fair market value determined by the Board, or the Committee if one has
         been appointed, in its discretion, which determination may, but need
         not, be based on (i) the advice of an independent financial advisor
         (which may be the Company's regular outside auditors) or (ii) the last
         known price per Share paid by a purchaser in an arm's length
         transaction; provided, however, that if there shall be a public market
         for the Shares, Fair Market Value shall mean (i) the closing price of
         the Shares on the principal stock exchange on which Shares are then
         traded or admitted to trading, on the last business day prior to the
         date on which the value is to be determined, (ii) if no sale takes
         place on such day on any such exchange, the average of the last
         reported closing bid and asked prices on such day as officially quoted
         on any such exchange, or (iii) if the Shares are not then listed or
         admitted to trading on any such exchange, the average of the last
         reported closing bid and asked prices on such day on the
         over-the-counter market. For purposes of (i) above, the National
         Association of Securities Dealers National Market System shall be
         deemed a principal stock exchange. If there shall be a public market
         for the Shares, and the foregoing references are unavailable or
         inapplicable, then the Fair Market Value shall be determined on the
         basis of the appropriate

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         substitute public market price indicator as determined by the
         Committee, in its sole discretion.

                  2.9 "Incentive Stock Option" means an Option meeting the
         requirements and containing the limitations and restrictions set forth
         in Section 422 of the Code.

                  2.10 "Non-Qualified Stock Option" means an Option other than
         an Incentive Stock Option.

                  2.11 "Option" means the right to purchase the number of Shares
         specified by the Board, or the Committee if one has been appointed, at
         a price and for a term fixed by the Board, or the Committee if one has
         been appointed, in accordance with the Plan, and subject to such other
         limitations and restrictions as the Plan or the Board or the Committee,
         as the case may be, may impose.

                  2.12 "Parent" means any corporation, other than the employer
         corporation, in an unbroken chain of corporations ending with the
         employer corporation if, at the time of the granting of the Option,
         each of the corporations other than the employer corporation owns stock
         possessing fifty percent (50%) or more of the total combined voting
         power of all classes of stock in one of the other corporations in such
         chain.

                  2.13 "Participants" means officers (including officers who are
         members of the Board), and other key employees, consultants and
         directors of the Company or any of its Subsidiaries.

                  2.14 "Plan" means the Company's 1995 Incentive Plan.

                  2.15 "Regulation T" means Part 220, chapter II, title 12 of
         the Code of Federal Regulations, issued by the Board of Governors of
         the Federal Reserve System pursuant to the Exchange Act, as amended
         from time to time, or any successor regulation which may hereafter be
         adopted in lieu thereof.

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                  2.16 "Restricted Stock Award Agreement" means an Award
         Agreement executed in connection with a Restricted Stock Award.

                  2.17 "Restricted Stock Award" means the right to receive
         Shares, but subject to forfeiture and/or other restrictions set forth
         in the related Restricted Stock Award Agreement and the Plan.

                  2.18 "Rule 16b-3" means Rule 16b-3 of the General Rules and
         Regulations of the Exchange Act, as in effect at the time of reference,
         or any successor rules or regulations which may hereafter be adopted in
         lieu thereof, and any reference to any specific provisions of Rule
         16b-3 shall refer to the corresponding provisions of Rule 16b-3 as it
         may hereafter be amended or replaced.

                  2.19 "Shares" means shares of the Company's common stock, no
         par value, or, if by reason of the adjustment provisions contained
         herein, any rights under an Award under the Plan pertain to any other
         security, such other security.

                  2.20 "Stock Bonus Award" means the right to receive Shares,
         without payment except as otherwise provided in Section 9 of the Plan.

                  2.21 "Stockholders Agreement" means a stockholders agreement
         required to be executed as a condition to the grant of an Award.

                  2.22 "Subsidiary" or "Subsidiaries" means any corporation or
         corporations other than the employer corporation in an unbroken chain
         of corporations beginning with the employer corporation if each of the
         corporations other than the last corporation in the unbroken chain owns
         stock possessing fifty percent (50%) or more of the total combined
         voting power of all classes of stock in one of the other corporations
         in such chain.

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                  2.23 "Successor" means the legal representative of the estate
         of a deceased Participant or the person or persons who shall acquire
         the right to exercise or receive an Award by bequest or inheritance or
         by reason of the death of the Participant.

                  2.24 "Term" means the period during which a particular Award
         may be exercised.

         3. STOCK SUBJECT TO THE PLAN. There will be reserved for use, upon the
exercise of Awards to be granted from time to time under the Plan, an aggregate
of 330 Shares, which Shares may be, in whole or in part, as the Board shall from
time to time determine, authorized but unissued Shares, or issued Shares which
shall have been reacquired by the Company. Any Shares subject to issuance upon
exercise of Options but which are not issued because of a surrender, lapse,
expiration or termination of any such Option prior to issuance of the Shares
shall once again be available for issuance in satisfaction of Awards. Similarly,
any Shares issued pursuant to a Restricted Stock Award which are subsequently
forfeited pursuant to the terms of the related Restricted Stock Award Agreement
shall once again be available for issuance in satisfaction of Awards.

         4. ADMINISTRATION OF THE PLAN. The Board shall be invested with the
responsibility for the administration of the Plan; provided, however, that the
Board may appoint a Committee which shall be invested with the responsibility
for the administration of the Plan; provided, further, however, that at such
time, if ever, that the Company becomes subject to the Exchange Act, the Board
shall appoint a Committee, which shall consist of not less than two (2)
disinterested persons as defined in Rule 16b-3, which shall be invested with the
responsibility for the administration of the Plan. Subject to the provisions of
the Plan, the Board, or the Committee if one has been appointed, shall have full
authority, in its discretion, to determine the Participants to whom Awards shall
be granted, the number of Shares to be covered by each of the Awards, and the
terms of any such Award; to amend or cancel Awards (subject to Section 20 of the
Plan), to accelerate the vesting of Awards; to require the cancellation or
surrender of any previously granted options or other awards

                                       -5-

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under this Plan or any other plans of the Company as a condition to the granting
of an Award; to interpret the Plan; and to prescribe, amend, and, rescind rules
and regulations relating to the Plan, and generally to interpret and determine
any and all matters whatsoever relating to the administration of the Plan and
the granting of Awards hereunder. All decisions or interpretations made by the
Board, or the Committee if one has been appointed, with regard to any question
arising under the Plan or any Award granted pursuant to the Plan shall be
binding and conclusive on the Company and the recipients of Awards. The Board
may from time to time appoint members to the Committee in substitution for or in
addition to members previously appointed and may fill vacancies, however caused,
in the Committee. The Committee, if one has been appointed, shall select one of
its members as its Chairman and shall hold its meetings at such times and places
as it shall deem advisable. A majority of its members shall constitute a quorum.
Any action of the Committee may be taken by a written instrument signed by all
of the members, and any action so taken shall be fully as effective as if it had
been taken by a vote of a majority of the members at a meeting duly called and
held. The Committee shall make such rules and regulations for the conduct of its
business as it shall deem advisable and shall appoint a Secretary who shall keep
minutes of its meetings and records of all action taken in writing without a
meeting. No member of the Committee shall be liable, in the absence of bad
faith, for any act or omission with respect to his service on the Committee.

         5. PARTICIPANTS TO WHOM AWARDS MAY BE GRANTED. Awards may be granted in
each calendar year or portion thereof while the Plan is in effect to such of the
Participants as the Board, or the Committee if one has been appointed, in its
discretion, shall determine; provided, however, that no Incentive Stock Options
may be granted to a Participant who is not an employee of the Company or any of
its Subsidiaries. In determining the Participants to whom Awards shall be
granted and the number of Shares to be subject to purchase under such Awards,
the Board, or the

                                       -6-

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Committee if one has been appointed, shall take into account the duties of the
respective Participants, their present and potential contributions to the
success of the Company and its Subsidiaries, and such other factors as the Board
or the Committee, as the case may be, shall deem relevant in connection with
accomplishing the purposes of the Plan. If the Company becomes subject to the
Exchange Act, then no Award shall thereafter be granted to any member of the
Committee so long as his membership on the Committee continues or to any member
of the Board who is not also an officer or key employee of the Company or any
Subsidiary.

         6. OPTIONS.

                  6.1 TYPES OF OPTIONS. Options granted under the Plan may be
         (i) Incentive Stock Options, (ii) Non-Qualified Stock Options, or (iii)
         a combination of the foregoing. The Award Agreement shall designate
         whether an Option is an Incentive Stock Option or a Non- Qualified
         Stock Option and separate Award Agreements shall be issued for each
         type of Option when a combination of an Incentive Stock Option and a
         Non-Qualified Stock Option are granted on the same date to the same
         Participant. Any Option which is designated as a Non-Qualified Stock
         Option shall not be treated by the Company or the Participant to whom
         the Option is granted as an Incentive Stock Option for federal income
         tax purposes.

                  6.2 OPTION PRICE. Unless otherwise determined by the Board, or
         the Committee if one has been appointed, in its sole discretion, the
         option price per share of any Non- Qualified Stock Option granted under
         the Plan shall not be less than the Fair Market Value of the Shares
         covered by the Option on the date the Option is granted. The option
         price per share of any Incentive Stock Option granted under the Plan
         shall not be less than the Fair Market Value of the Shares covered by
         the Option on the date the Option is granted.

                  Notwithstanding anything herein to the contrary, in the event
         an Incentive Stock Option is granted to a Participant who, at the time
         such Incentive Stock Option is granted,

                                       -7-

<PAGE>   8

         owns, as defined in Section 424 of the Code, stock possessing more than
         ten percent (10%) of the total combined voting power of all classes of
         stock of:

                         (i)        the Company; or

                        (ii)        if applicable, a Subsidiary; or

                       (iii)        if applicable, a Parent,

         then the option price per share of any Incentive Stock Option granted
         to such Participant shall not be less than one hundred ten percent
         (110%) of the Fair Market Value of the Shares covered by the Option on
         the date the Option is granted.

                  6.3 TERMS OF OPTIONS. Options granted hereunder shall be
         exercisable for a Term of not more than ten (10) years from the date of
         grant thereof, but shall be subject to earlier termination as
         hereinafter provided. Each Award Agreement issued hereunder shall
         specify the term of the Option, which Term shall be determined by the
         Board, or the Committee if one has been appointed, in accordance with
         its discretionary authority hereunder.

                  Notwithstanding anything herein to the contrary, in the event
         an Incentive Stock Option is granted to a Participant who, at the time
         such Incentive Stock Option is granted, owns, as defined in Section 424
         of the Code, stock possessing more than ten percent (10%) of the total
         combined voting power of all classes of stock of:

                         (i)        the Company; or

                        (ii)        if applicable, a Subsidiary; or

                       (iii)        if applicable, a Parent,

         then such Incentive Stock Option shall not be exercisable more than
         five (5) years from the date of grant thereof, but shall be subject to
         earlier termination as hereinafter provided.

         7. LIMIT ON FAIR MARKET VALUE OF INCENTIVE STOCK OPTIONS. No
Participant may be granted an Incentive Stock Option hereunder to the extent
that the aggregate fair market value (such

                                       -8-

<PAGE>   9

fair market value being determined as of the date of grant of the option in
question) of the stock with respect to which incentive stock options are first
exercisable by any Participant during any calendar year (under all such plans of
the Participant's employer corporation, its Parent, if any, and its
Subsidiaries, if any) exceeds One Hundred Thousand Dollars ($100,000). For
purposes of the preceding sentence, options shall be taken into account in the
order in which they were granted. Any Option granted under the Plan which is
intended to be an Incentive Stock Option, but which exceeds the limitation set
forth in this Section 7, shall be a Non-Qualified Stock Option.

         8. RESTRICTED STOCK AWARDS. Restricted Stock Awards granted under the
Plan shall be subject to such terms and conditions as the Board, or the
Committee if one has been appointed, may, in its discretion, determine.
Recipients of Restricted Stock Awards shall pay the Company an amount equal to
the aggregate par value of the Shares to be issued pursuant to the Restricted
Stock Awards. Restricted Stock Awards issued under the Plan shall be evidenced
by Restricted Stock Award Agreements in such form as the Board, or the Committee
if one has been appointed, may from time to time determine.

                  8.1 ISSUANCE OF SHARES. Each Restricted Stock Award Agreement
         shall set forth the number of Shares issuable under the Restricted
         Stock Award evidenced thereby. Subject to the restrictions in Section
         8.3 of the Plan and as set forth in the related Restricted Stock Award
         Agreement, and the satisfaction of any condition precedent to the grant
         of a Restricted Stock Award (such as the execution of a Stockholders
         Agreement), the number of Shares granted under a Restricted Stock Award
         shall be issued to the recipient Participant thereof on the date of
         grant of such Restricted Stock Award or as soon as may be practicable
         thereafter.

                  8.2 RIGHTS OF RECIPIENT PARTICIPANTS. Shares received pursuant
         to Restricted Stock Awards shall be duly issued or transferred to the
         Participant, and a certificate or certificates

                                       -9-

<PAGE>   10

         for such Shares shall be issued in the Participant's name. Subject to
         the restrictions in Section 8.3 of the Plan and as set forth in the
         related Restricted Stock Award Agreement, the Participant shall
         thereupon be a stockholder with respect to all the Shares represented
         by such certificate or certificates and shall have all the rights of a
         stockholder with respect to such Shares, including the right to vote
         such Shares and to receive dividends and other distributions paid with
         respect to such Shares. In aid of such restrictions, certificates for
         Shares awarded hereunder, together with a suitably executed stock power
         signed by each recipient Participant, shall be held by the Company in
         its control for the account of such Participant until either (i) the
         restrictions determined by the Board, or the Committee if one has been
         appointed, in its discretion, and as set forth in the related
         Restricted Stock Award Agreement, lapse pursuant to the Plan or the
         Restricted Stock Award Agreement, at which time a certificate for the
         appropriate number of Shares (free of all restrictions imposed by the
         Plan or the Restricted Stock Award Agreement) shall be delivered to the
         Participant, or (ii) such Shares are forfeited to the Company and
         cancelled as provided by the Plan or the Restricted Stock Award
         Agreement.

                  8.3 RESTRICTIONS. Except as otherwise determined by the Board,
         or the Committee if one has been appointed, in its sole discretion,
         each Share issued pursuant to a Restricted Stock Award Agreement shall
         be subject, in addition to any other restrictions set forth in the
         related Restricted Stock Award Agreement, to the following restrictions
         until such restrictions have lapsed pursuant to Section 8.4 of the Plan
         or the related Restricted Stock Award Agreement:

                           (a) DISPOSITION. The Shares awarded to a Participant
                  and held by the Company pursuant to Section 8.2 of the Plan,
                  and the right to vote such Shares or receive dividends on such
                  Shares, may not be sold, exchanged, transferred, pledged,

                                      -10-

<PAGE>   11

                  hypothecated or otherwise disposed of; provided, however, that
                  such Shares may be transferred upon the death of the
                  Participant to the Participant's Successor. Any transfer or
                  purported transfer of such Shares in violation of the
                  restrictions outlined in this Section 8.3 shall be null and
                  void and shall result in the forfeiture of the Shares
                  transferred or purportedly transferred to the Company without
                  notice and without consideration.

                           (b) FORFEITURE. The Shares awarded to a Participant
                  and held by the Company pursuant to Section 8.2 of the Plan
                  shall be forfeited to the Company without notice and without
                  consideration therefor immediately upon the termination of
                  Participant's employment with the Company, and all
                  Subsidiaries of the Company, for any reason other than death,
                  disability, retirement or the Participant's attainment of age
                  sixty-five (65).

                  8.4 LAPSE OF RESTRICTIONS. Except as otherwise determined by
         the Board, or the Committee if one has been appointed, in its sole
         discretion, the restrictions set forth in Section 8.3 of the Plan on
         Shares issued under a Restricted Stock Award shall lapse, and
         certificates for the Shares held for the account of the Participant in
         accordance with Section 8.2 of the Plan hereof shall be appropriately
         distributed to the Participant on the earlier of:

                           (a) the Participant's death;

                           (b) the termination of the Participant's employment
                  by reason of the Participant being "disabled" as defined in
                  Section 22(e)(3) of the Code;

                           (c) the Participant's retirement pursuant to the
                  retirement plans of the Company or any of its Subsidiaries;

                           (d) the Participant's attainment of age sixty-five
                  (65); or

                                      -11-

<PAGE>   12

                           (e) (i) the first anniversary of the date of grant
                  with respect to one-third (1/3) of the Shares originally
                  awarded,

                               (ii) the second anniversary of the date of grant
                           with respect to an additional one-third (1/3) of the
                           Shares originally awarded, and

                               (iii) the third anniversary of the date of grant
                           with respect to the balance of the Shares originally
                           awarded.

         9. STOCK BONUS AWARDS. Stock Bonus Awards may be granted under the Plan
with respect to Shares, and shall be granted, subject to the provisions of the
Plan, upon such terms and conditions as the Board, or the Committee if one has
been appointed, may determine in its discretion. The Board, or the Committee if
one has been appointed, in its discretion, may require Participants to whom
Stock Bonus Awards are granted to execute a Stockholders Agreement as a
condition precedent to the grant of such Stock Bonus Awards. Subject to the
Participant delivering in cash or by check the amount required to be paid
pursuant to Section 18 of the Plan (relating to taxes), and, if required as a
condition of grant, a properly executed Stockholders Agreement in the form
prescribed by the Board, or the Committee if one has been appointed, a
certificate or certificates for such Shares shall be issued in the Participant's
name as soon as reasonably practicable following the date of grant, or if such
payment is required, following the date of such payment. The Company shall
deliver such certificate or certificates to the Participant and the Participant
shall thereupon be a stockholder with respect to all Shares represented by such
certificate or certificates and shall have all the rights of a stockholder with
respect to such Shares.

         10. DATE OF GRANT. The date of grant of an Award granted hereunder
shall be the date on which the Board, or the Committee if one is appointed, acts
in granting the Award.

                                      -12-

<PAGE>   13

         11. EXERCISE OF RIGHTS UNDER OPTIONS.

                  11.1 NOTICE OF EXERCISE. A Participant entitled to exercise an
         Option may do so by delivery of a written notice to that effect
         specifying the number of Shares with respect to which the Option is
         being exercised and any other information the Board, or the Committee
         if one has been appointed, may prescribe. The notice shall be
         accompanied by payment in full of the purchase price of any Shares to
         be purchased, which payment may be made in cash or, with the Board's or
         the Committee's approval, as the case may be, in Shares valued at Fair
         Market Value at the time of exercise or a combination thereof. No
         Shares shall be issued upon exercise of an Option until full payment
         has been made therefor. All notices or requests provided for herein
         shall be delivered to the President of the Company, or such other
         person as the Board or the Committee, as the case may be, shall
         designate.

                  11.2 CASHLESS EXERCISE PROCEDURES. At such time, if ever, that
         Shares are traded on the over-the-counter market or on any other
         established securities market, the Company, in its sole discretion, may
         establish procedures whereby a Participant, subject to the requirements
         of Rule 16b-3, Regulation T, federal income tax laws, and other
         federal, state and local tax and securities laws, can exercise an
         Option or a portion thereof without making a direct payment of the
         option price to the Company; provided, however, that these cashless
         exercise procedures shall not apply to Incentive Stock Options which
         are outstanding on the date the Company establishes such procedures
         unless the application of such procedures to such Options is permitted
         pursuant to the Code and the regulations thereunder without affecting
         the Options' qualification under Code Section 422 as Incentive Stock
         Options. If the Company so elects to establish a cashless exercise
         program, the Company shall determine, in its sole discretion, and from
         time to time, such administrative procedures and

                                      -13-

<PAGE>   14

         policies as it deems appropriate and such procedures and policies shall
         be binding on any Participant wishing to utilize the cashless exercise
         program.

                  11.3 PAYMENT OF "SPREAD" ONLY. Notwithstanding anything to the
         contrary in this Plan, if (i) the Company receives notice from a
         Participant that such Participant is exercising an Option and (ii) the
         Company would be entitled pursuant to the Stockholders Agreement to
         purchase the Shares to be acquired by the Participant upon exercise of
         the Option, the Company, in its discretion, may pay the Participant, in
         the same manner set forth in the Stockholders Agreement, an amount
         equal to the Purchase Price (as defined in the Stockholders Agreement)
         of the Shares to be acquired upon exercise of the Option, less the
         option price of such Shares; in which event the Company shall be under
         no obligation to issue such Shares to the Participant, the Participant
         shall be under no obligation to pay the option price of such Shares and
         the Company shall return any option price paid by the Participant to
         the Company with respect to such Shares.

         12. AWARD TERMS AND CONDITIONS. Each Award or each Award Agreement
setting forth an Award shall contain such other terms and conditions not
inconsistent herewith as shall be approved by the Board, or by the Committee if
one has been appointed.

         13. RIGHTS OF AWARD HOLDER. The holder of an Award shall not have any
of the rights of a stockholder with respect to the Shares subject to purchase or
receipt under his Award, except to the extent that one or more certificates for
such Shares shall be delivered to him upon the due exercise or grant of the
Award.

         14. NONTRANSFERABILITY OF AWARDS. An Award shall not be transferable,
other than: (a) by will or the laws of descent and distribution, and an Award
may be exercised, during the lifetime of the holder of the Award, only by the
holder or in the event of death, the holder's Successor, or in the event of
disability, the holder's personal representative, or (b) pursuant to a

                                      -14-

<PAGE>   15

qualified domestic relation order, as defined in the Code or the Employee
Retirement Income Security Act (ERISA) or the rules thereunder; provided,
however, that an Incentive Stock Option may not be transferred pursuant to a
qualified domestic relations order unless such transfer is otherwise permitted
pursuant to the Code and the regulations thereunder without affecting the
Option's qualification under Code Section 422 as an Incentive Stock Option.

         15. ADJUSTMENTS UPON CHANGES IN CAPITALIZATION. In the event of changes
in all of the outstanding Shares by reason of stock dividends, stock splits,
recapitalizations, mergers, consolidations, combinations, or exchanges of
shares, separations, reorganizations or liquidations, or similar events, or in
the event of extraordinary cash or non-cash dividends being declared with
respect to the Shares, or similar transactions or events, the number and class
of Shares available under the Plan in the aggregate, the number and class of
Shares subject to Awards theretofore granted, applicable purchase prices and all
other applicable provisions, shall, subject to the provisions of the Plan, be
equitably adjusted by the Board, or the Committee if one has been appointed
(which adjustment may, but need not, include payment to the holder of an Option,
in cash or in shares, in an amount equal to the difference between the price at
which such Option may be exercised and the then current Fair Market Value of the
Shares subject to such Option as equitably determined by the Board or the
Committee, as the case may be). The foregoing adjustment and the manner of
application of the foregoing provisions shall be determined by the Board or the
Committee, as the case may be, in its sole discretion. Any such adjustment may
provide for the elimination of any fractional share which might otherwise become
subject to an Award.

         16. UNUSUAL CORPORATE EVENTS. Notwithstanding anything to the contrary,
in the case of an unusual corporate event such as liquidation, merger,
reorganization (other than a reorganization as defined by Section 368(a)(1)(F)
of the Code), or other business combination, acquisition or change in the
control of the Company through a tender offer or otherwise, the Board may, in
its sole

                                      -15-

<PAGE>   16

discretion, determine, on a case by case basis, that each Award granted under
the Plan shall terminate ninety (90) days after the occurrence of such unusual
corporate event, but, in the event of any such termination:

                  (a) An Option holder shall have the right, commencing at least
         five (5) days prior to such unusual corporate event and subject to any
         other limitation on the exercise of such Option in effect on the date
         of exercise to immediately exercise any Option in full, without regard
         to any vesting limitations, to the extent such Option shall not have
         been exercised, and

                  (b) All restrictions on Restricted Stock Awards shall
         immediately lapse and certificates for the affected Shares shall be
         appropriately distributed.

         17. FORMS OF AWARDS. Nothing contained in the Plan nor any resolution
adopted or to be adopted by the Board or by the stockholders of the Company
shall constitute the granting of any Award. An Award shall be granted hereunder
only by action taken by the Board, or Committee if one has been appointed, in
granting an Award. Whenever the Board or the Committee, as the case may be,
shall designate a Participant for the receipt of an Award, the President of the
Company, or such other person as the Board or the Committee, as the case may be,
shall designate, shall forthwith send notice thereof to the Participant, in such
form as the Board or the Committee, as the case may be, shall approve, stating
the number of Shares subject to Award, its Term, and the other terms and
conditions thereof. The notice shall be accompanied by a written Award Agreement
in such form as may from time to time hereafter be approved by the Board or the
Committee, as the case may be, which shall have been duly executed by or on
behalf of the Company. If the surrender of previously issued Awards is made a
condition of the grant, the notice shall set forth the pertinent details of such
condition. Execution by the Participant to whom such Award is granted of said
Award Agreement in accordance with the provisions set forth in this Plan shall
be a condition precedent to the exercise or grant of any Award.

                                      -16-

<PAGE>   17

         18. TAXES.

                  18.1 RIGHT TO WITHHOLD REQUIRED TAXES. The Company shall have
         the right to require a person entitled to receive Shares pursuant to
         the receipt or an exercise of an Award under the Plan to pay the
         Company the amount of any taxes which the Company is or will be
         required to withhold with respect to such Shares before the certificate
         for such Shares is delivered pursuant to the Award. Furthermore, the
         Company may elect to deduct such taxes from any other amounts then
         payable in cash or in shares or from any other amounts payable any time
         thereafter to the Participant. If the Participant disposes of Shares
         acquired pursuant to an Incentive Stock Option in any transaction
         considered to be a disqualifying transaction under Sections 421 and 422
         of the Code, the Participant shall notify the Company of such transfer
         and the Company shall have the right to deduct any taxes required by
         law to be withheld from any amounts otherwise payable then or at any
         time thereafter to the Participant.

                  18.2 PARTICIPANT ELECTION TO WITHHOLD SHARES. Subject to Board
         approval, or Committee approval if one had been appointed, a
         Participant may elect to satisfy his tax liability with respect to the
         exercise of an Option by having the Company withhold Shares otherwise
         issuable upon exercise of the Option; provided, however, that if a
         Participant is subject to Section 16(b) of the Exchange Act, such
         election must satisfy the requirements of Rule 16b-3.

         19. TERMINATION OF THE PLAN. The Plan shall terminate ten (10) years
from the date hereof, and an Award shall not be granted under the Plan after
that date although the terms of any Awards may be amended at any date prior to
the end of its Term in accordance with the Plan. Any Awards outstanding at the
time of termination of the Plan shall continue in full force and effect
according to the terms and conditions of the Award and this Plan.

                                      -17-

<PAGE>   18

         20. AMENDMENT OF THE PLAN. The Plan may be amended at any time and from
time to time by the Board, but no amendment without the approval of the
stockholders of the Company shall be made if stockholder approval under Section
422 of the Code (or any successor provision) or Rule 16b-3 (if the Company is
subject to the Exchange Act at the time of such amendment) would be required.
Notwithstanding the discretionary authority granted to the Board, or the
Committee if one has been appointed, in Section 4 of the Plan, no amendment of
the Plan or any Award granted under the Plan shall impair any of the rights of
any holder, without such holder's consent, under any Award theretofore granted
under the Plan.

         21. DELIVERY OF SHARES ON EXERCISE. Delivery of certificates for Shares
pursuant to the grant or exercise of an Award may be postponed by the Company
for such period as may be required for it with reasonable diligence to comply
with any applicable requirements of any federal, state or local law or
regulation or any administrative or quasi-administrative requirement applicable
to the sale, issuance, distribution or delivery of such Shares. The Board, or
the Committee if one has been appointed, may, in its sole discretion, require a
Participant to furnish the Company with appropriate representations and a
written investment letter prior to the exercise of an Award or the delivery of
any Shares pursuant to an Award.

         22. FEES AND COSTS. The Company shall pay all original issue taxes on
the grant or exercise of any Award granted under the Plan and all other fees and
expenses necessarily incurred by the Company in connection therewith.

         23. EFFECTIVENESS OF THE PLAN. The Plan shall become effective when
approved by the Board. The Plan shall thereafter be submitted to the Company's
stockholders for approval and unless the Plan is approved either (i) by the
affirmative votes of the holders of shares having a majority of the voting power
of all shares represented at a meeting duly held in accordance with Ohio law
within twelve (12) months after being approved by the Board or (ii) by a
unanimous written consent in

                                      -18-

<PAGE>   19

accordance with Ohio law within twelve (12) months after being approved by the
Board, the Plan and all Awards made under it shall be void and of no force and
effect.

         24. OTHER PROVISIONS. As used in the Plan, and in Award Agreements and
other documents prepared in implementation of the Plan, references to the
masculine pronoun shall be deemed to refer to the feminine or neuter, and
references in the singular or the plural shall refer to the plural or the
singular, as the identity of the person or persons or entity or entities being
referred to may require. The captions used in the Plan and in such Award
Agreements and other documents prepared in implementation of the Plan are for
convenience only and shall not affect the meaning of any provision hereof or
thereof.

         25. OHIO LAW TO GOVERN. This Plan shall be governed by and construed in
accordance with the laws of the state of Ohio.

                                      -19-

<PAGE>   20
                                 FIRST AMENDMENT
                                     TO THE
                             1995 INCENTIVE PLAN OF
                                 ATHERSYS, INC.

         This FIRST AMENDMENT to the 1995 Incentive Plan (the "Plan") is adopted
by the Board of Directors of Athersys, Inc. and is effective as of the 30th day
of June, 1998.

         The Plan is amended as follows:

         1. The first sentence of section 3 is amended to read as follows:

                  "3. STOCK SUBJECT TO THE PLAN. There will be reserved for use,
         upon the exercise of Awards to be granted from time to time under the
         Plan, an aggregate of 930 Shares, which Shares may be, in whole or in
         part, as the Board shall from time to time determine, authorized but
         unissued Shares, or issued Shares which shall have been reacquired by
         the Company."

The portions of the Plan unaffected by this FIRST AMENDMENT shall remain in full
force and effect.

<PAGE>   21
                                SECOND AMENDMENT
                                     TO THE
                             1995 INCENTIVE PLAN OF
                                 ATHERSYS, INC.

         This SECOND AMENDMENT to the 1995 Incentive Plan (the "Plan") is
adopted by the Board of Directors of Athersys, Inc., subject to stockholder
approval, and is effective as of the 21st day of June, 1999.

         The Plan is amended as follows:

         1. The first sentence of section 3 is amended and restated to
read as follows:

                  "3. STOCK SUBJECT TO THE PLAN. There will be reserved for use,
         upon the exercise of Awards to be granted from time to time under the
         Plan, an aggregate of 3,690,000 Shares, which Shares may be, in whole
         or in part, as the Board shall from time to time determine, authorized
         but unissued Shares, or issued Shares which shall have been reacquired
         by the Company."

The portions of the Plan unaffected by this SECOND AMENDMENT shall remain in
full force and effect.

<PAGE>   22
                                 THIRD AMENDMENT
                                     TO THE
                      1995 INCENTIVE PLAN OF ATHERSYS, INC.

         This THIRD AMENDMENT to the 1995 Incentive Plan of Athersys, Inc. (the
"Plan") is adopted by the Board of Directors of Athersys, Inc., subject to
stockholder approval, and is effective as of the 30th day of March, 2000.

         The Plan is amended as follows:

         1. The first sentence of section 3 of the Plan is hereby amended and
restated to read as follows:

                  "3. STOCK SUBJECT TO THE PLAN. There will be reserved for use,
         upon the exercise of Awards to be granted from time to time under this
         Plan, an aggregate of 4,000,000 Shares, which Shares may be, in whole
         or in part, as the Board shall from time to time determine, authorized
         but unissued Shares, or issued Shares which shall have been reaquired
         by the Company."

The portions of the Plan unaffected by this THIRD AMENDMENT shall remain in full
force and effect.

<PAGE>   23
                                FOURTH AMENDMENT
                                     TO THE
                      1995 INCENTIVE PLAN OF ATHERSYS, INC.

         THIS FOURTH AMENDMENT to the 1995 Incentive Plan of Athersys, Inc. (the
"PLAN") is adopted by the Board of Directors of Athersys, Inc., and is effective
as of the 23rd day of May, 2000.

         Section 2.19 of the Plan is hereby amended and restated in its entirety
as follows:

            2.19  "Shares" means shares of the Company's common stock, $.01 par
                  value, or, if by reason of the adjustment provisions contained
                  herein, any rights under an Award under the Plan pertain to
                  any other security, such other security.

         Section 25 of the Plan is hereby amended and restated in its entirety
as follows:

            25.   DELAWARE LAW TO GOVERN. This Plan shall be governed by and
construed in accordance with the laws of the state of Delaware.

The portions of the Plan unaffected by this FOURTH AMENDMENT shall remain in
full force and effect.

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