Document:

Exhibit 4.21

 

 

 

CONFIDENTIAL

 

 

THE SYMBOL "[****]" DENOTES PLACES
WHERE PORTIONS OF THIS DOCUMENT HAVE BEEN OMIITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT. SUCH MATERIAL HAS BEEN FILED
SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION

 

MASTER AGREEMENT WORK ORDER

AMENDMENT #1

 

Protocol # RHB-104-01 (MAP and Other Analysis)

 

Effective Date: date of last signature below

 

RedHill Biopharma

21 Ha’arba’a St.

Tel-Aviv Israel 64739

 

WHEREAS, RedhIll Biopharma Ltd. and Quest Diagnostics Clinical Laboratories, Inc. are
parties (together the “Parties”) to a Clinical Trials Global Master Services Agreement dated 27-December-2015 (the
“Agreement”) and have also entered into a Work Order on 10-Oct-2013 pursuant to Protocol RHB-104-01 (the “Work
Order”).

 

WHEREAS, Quintiles Laboratories and Quest Diagnostics have formed the company Q Squared
Solutions (Quest) LLC, to provide certain laboratory services (including central and bio-analytical laboratory services).

 

WHEREAS, pursuant to the joint venture described in the above recital, Q Squared Solutions
(Quest) LLC will hereinafter perform the Services under the Agreement, and all references to Quest Diagnostics Clinical Laboratories,
Inc. in the Agreement, the Work Order and this Amendment #1 shall reflect Q Squared Solutions (Quest) LLC (hereinafter “Q
Squared”) following the effective date of this Amendment.

 

NOW THEREFORE, the Parties agree as follows:

 

1.           
The purpose of this Amendment #1 to the Work Order is to revise the budget, update the project term and to provide services
by Q Squared Solutions.

 

2.           
The Term of the Agreement shall now be as follows:

Effective Date: 10-Oct-2013 End Date: [****]

 

		3.	The Budget has been updated to reflect :

		·	the addition of Australia and New Zealand;

		·	an estimate for optional [****]use in the US only;

		·	the addition of [****];

		·	updated [****], [****], [****]

		·	that Israel and [****]shipping costs from sites direct [****]have
been line itemed until Quest is notified to begin shipping directly and the budget will be updated with these costs at that time;

		·	outbound shipping of [****]is included - estimating [****]per
site;

		·	the inclusion of[****];

		·	the addition of [****]: [****], [****], [****], [****],
[****], [****];

		·	additional updates made to [****], [****] per client request;

		·	the addition of [****]

 

    	
RedHill Biopharma Limited
Protocol # RHB-104-01
Master Agreement Work Order, Amendment #1

	Page 1 of 3

     

    

 

		·	and a revised [****] sample volume;

		·	add [****]([****] sites/[****]
screen/[****] randomized);

		·	remove [****] patients from [****] to move to [****];

		·	update visit names;

		·	study amendment fee;

		·	update to [****];

		·	[****];

		·	[****];

		·	Add [****], [****] to be sent to [****];

		·	change to [****];

		·	New kit for [****];

		·	costs added for [****];

		·	extend DNA storage length to 10 years.

 

4. The revised Estimated Central Laboratory Budget is attached hereto as Attachment #1,
is incorporated herein by reference, and shall replace the Attachment #1 of the Work Order.

 

5. The study value is revised as follows:

 

	Document	Change Value	
        Total Study 

        Contracted Value*

	Original Work Order	$0.00	$[****]
	Amendment #1	$[****]	$[****]

*RedHill shall be invoiced for actual tests performed and services
rendered.

 

6. All other terms and conditions of the Work Order and the Clinical Trials Global Master
Services Agreement (the “Agreement”) shall remain in full force and effect. In the event of any conflict between the
terms of the Agreement, the Work Order, and this Amendment, the terms of this Amendment shall control.

 

7. The parties hereto agree to this Amendment #1 as of the effective date by authorized
signature below.

 

	REDHILL BIOPHARMA LIMITED	 	Q Squared Solutions (Quest) LLC	 
	 	 	 	 
	 	 	 	 
	/s/ Dror Ben Asher     /s/ Ori Shilo	 	/s/ Terrence D. Burke	 
	Authorized Signature	 	Terrence D Burke	 
	 	 	Authorized Person	 
	Dror Ben-Asher               Ori Shilo  	 	 	 
	Name Printed	 	 	 
	 	 	 	 
	CEO                          Deputy CEO	 	 	 
	Title	 	 	 
	 	 	 	 
	December 29, 2015	 	December 30, 2015	 
	Date	 	Date	 

 

    	
RedHill Biopharma Limited
Protocol # RHB-104-01
Master Agreement Work Order, Amendment #1

	Page 2 of 3

     

    

Attachment # 1

Protocol # RHB-104-01 (MAP and Other Analysis)

 

 

[The Quest Diagnostics Budget Version #16, dated 2-Sep-2015, is attached
hereto, is incorporated herein, contains 27 printed pages, and shall be printed in full for contract signature]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

    	
RedHill Biopharma Limited
Protocol # RHB-104-01
Master Agreement Work Order, Amendment #1

	Page 3 of 3

     

    

 

CONFIDENTIAL

 

 

	 	 	 
	 	 	 
	 	 	 

 

 

 

 Q2 Solutions, a Quintiles Quest Joint Venture

Central
Laboratory Services Budget

 

Q2 Solutions, a Quintiles Quest Joint Venture (JV), brings together the clinical trials laboratory operations of the two parent organizations to provide biopharmaceutical customers with the diverse capabilities and end-to-end services required in the rapidly evolving biopharmaceutical industry.  The new organization creates a global laboratory network that combines Quintiles’ scale, clinical trial expertise, and diverse therapeutic experience with Quest Diagnostics’ operational, scientific and quality excellence, supply-chain network and informatics to promote greater innovation, quality and  value for biopharmaceutical customers.

 

 RedHill Biopharma Limited

 RHB-104-01 (CR)

 Version 16

 2-Sep-15

 

	 	 	 	 
	 	 	 	 
	Prepared for:   	[****]	by:   	[****]
	 	[****]	 	[****]
	 	[****]	 	[****]
	                         	[****]	 	[****]
	              	[****]	 	[****]
	 	 	 	[****]
	 	 	 	 
	 	 	 	 
	Tel:   	[****]	Tel:   	[****]
	 	 	Fax:   	[****]
	Email:   	[****]	Email:   	[****]

 

 

 

     

     

    

 

	 	 	 
	 	 	 
	 	 	 

 

	2-Sep-15	 
	 	 
	Patrick L. McLean
	Product Manager
	RedHill Biopharma Limited
	21 Ha’arba’a St.
	Tel-Aviv  Israel  64739
	 	 
	 	 
	Regarding:	Centralized Clinical Laboratory and Related Support Services for Protocol 
	 	RHB-104-01 (CR)
	 	 
	Dear Patrick :	 
	 	 
	Thank you for the opportunity to submit a revised budget for your study. This budget
    includes the  following changes. 
	 	 
	 	version16:

- add [****] ([****] sites/[****] screen/[****] randomized)

- remove [****] patients from US to move to [****]

- update visit names

- study amendment fee: update to [****], Initial [****] receiving reported
as [****].  Remaining [****] to be [****], add [****], AUS/NZ MAP to be sent to [****],[****], New kit for [****] collection

- costs added for [****]

- extend DNA storage length to 10 years

 

Q2 Solutions,
a Quintiles Quest Joint Venture has a commitment to peak performance, superior value for our customers, teamwork, innovation
and integrity.  We look forward to the opportunity to work with you to demonstrate our dedication to these
values.

 

If you have any questions or require further assistance, please feel free to call me.

 

Yours sincerely,

 

 

[****]

Senior Strategic Account Executive

Q2 Solutions, a Quintiles Quest Joint Venture   

 

 

 

     

     

    

 

	RedHill Biopharma Limited	Quote for Services	 
	 	 	 
		Assumptions

                                                                       Protocol: RHB-104-01 (CR)
	

 

Assumptions:

 

Global Phase III trial

[****] countries, [****] sites: Israel: [****] sites, US/Canada: [****] sites, AUS:  [****],
NZ:  [****], respectively, [****]:  [****] sites, [****]:  [****] sites

[****] screened , [****] baseline to visit [****], and decreasing number of patients from visit [****] to visit [****]

Recommended couriers:

Israel-  sites to [****], sites to Quest ([****],[****] and [****]and [****]),

[****]-  sites to [****] ([****],[****]), sites to Quest [****] ([****], [****] and [****] and [****]),

[****]-  sites to [****] ([****], [****]), sites to Quest [****] ([****], [****]and [****] and [****]),

Canada - sites to [****] ([****] and [****]), sites to Quest [****] ([****] and [****]),

US- sites to [****] ([****]), sites to Quest [****] ([****]),

Quest [****]

[****] to Quest US- [****] ([****])

Courier mapping- [****],[****],[****]:

Sites to Quest [****],

Sites to Quest [****], [****], [****].

Sites to Quest [****], [****].

Sites to [****]

Quest UK to [****], [****]

Courier mapping- [****] /Australia/New Zealand

Sites to Quest [****]

Sites to Quest [****], [****], [****].

Sites to [****]

Sites to [****], [****].

[****] to Quest [****]

Inbound budget (shipments from sites to Quest Diagnostics): [****], [****]

[****], [****].

PK [****]

PK [****], [****].

Worst case scenario: we assume [****] to be revised in accordance to validation data.

PK [****] 

HIV Western Blot- we assume [****] 

[****]:

1- [****],

2- [****],

3- [****],

4- [****],

5- [****].

[****]

Stored specimen:

For bidding purpose, we assume average storage of [****]. [****].

DNA extraction samples are due to be stored for 10 years.

Note: RedHill Biopharma is charged for rendered services only.

[****]-

[****] ([****], [****]) [****].

[****].

[****]

[****]

[****]

[****]

 

Week-end shipments from sites - [****]

EWP(extreme weather packaging)- [****].

Australia and New Zealand supplies are sourced from the
US, these quantities are reflected in US region.

 

- [****]:

- [****] sites ([****] Aust, [****] NZ)

- [****] total visits plus ET

- [****] Enrolled ([****] total patient visits)

- supplies are sourced locally

 

 Forceps can only be shipped in US; remaining countries will be sourced locally by RHB.

 

     

     

    

 

	RedHill Biopharma Limited	Quote for Services	 
	 	 	 
		Change In Scope History

                                                                       Protocol: RHB-104-01 (CR)
	

 

	Category	Updated Study Value	Previous Study Value *	Difference	Comments
	Laboratory
    Testing	$[****]	$[****]	$[****]	Addition of [****] patients ([****]
    screened/[****] randomized/[****] completed):  total of [****] additional patient visits
	Supplies	$[****]	$[****]	$[****]	EU supplies increase of [****]%
    to account for [****] patients.
	Additional
    Pass-Through Services	$[****]	$[****]	$[****]	Reduction in US weekend shipments for patients that moved under
    [****]:-$[****]

    [****]budget:  $[****]

    [****] outbound sample shipping:  $[****]

    [****] weekend shipments:  $[****]
	Study
    Management	$[****]	$[****]	$[****]	Capture all amendment charges:

    - update to [****]

    - add [****]

    - change to AUS/NZ [****] to [****]

    - change to [****]

    - New kit for [****] 

    Per visit quantities updated to capture [****] patients
	Storage
    & Services	$[****]	$[****]	$[****]	[****]
	Inbound
    Transportation	$[****]	$[****]	$[****]	Adjustment to account for [****]
    shipping
	Batched
    Inbound	$[****]	$[****]	$[****]	Adjustment to account for [****]
    shipping
	Outbound
    Transportation	$[****]	$[****]	$[****]	Adjustment to account for [****]
    shipping
	Outbound
    Transportation - Shipping Containers	$[****]	$[****]	$[****]	Adjustment to account for [****]
    shipping
	Estimated
    Central Laboratory Budget:	$[****]	$[****]	$[****]	 

 

  * Budget taken from RedHill Biopharma Limited:  RHB-104-01 (CR).v15

 

	Date	Reason	Total Value	Difference	 
	31-Oct-11	Original	$[****]	$[****]	 
	14-Nov-11	Version2
    reflects the amended protocol (28October 2011)-  MAP testing and Chemistry/Hematology/Inflammatory markers/Urinalysis/Other
    AP markers	$[****]	$[****]	 
	24-Nov-11	version3:
    updated MAP testing processes/pricing, increasing number of MAP tests, expanded stool culture COP panel (addition of [****]
    agents: [****])	$[****]	$[****]	 
	21-Dec-11	version4:
    MAP validations/testing and other analysis

    [****]: revised countries:patients distribution for USA, Canada versus Israel resulting in a
    grand total of [****] screned/ week26-week[****] patients in North America and [****] patients in Europe

    Combined shipments(ambient/frozen) at screening, [****] and [****] 

    Updated selection of couriers in Canada and US for ambient shipments with [****] and Quest courier
    respectively	$[****]	$[****]	 
	11-Jan-12	Version
    5:  Updated discounting in testing and study management section.	$[****]	$[****]	 
	29-Aug-12	version6
    reflects

    Protocol dated 22-Aug-2012

    Updated country:site:visit:patient distribution.

    3 countries, [****] sites, [****] screened/other visits patients

    Routine clinical laboratory tests (hematology, biochemistry, inflammatory markers and stool
    tests performed at Quest Diagnostics. 

    Viral serology performed at screening visit.

    Urine pregnancy kits and urinalysis dipsticks to be supplies by Quest to sites

    [****]assay performed at Quest Diagnostics (frozen whole blood),

    Additional samples of [****]blood([****]) collected and frozen at weeks [****]. These samples
    will be retained at Quest Diagnostics during the course of the study for future MAP assessment.  

    PK specimens management

    Courier model as follow: (1) Combined shipments (ambient and frozen) at screening, [****] only.	$[****]	$[****]	 
	7-Mar-13	version
    7 reflects FINAL protocol dated 20Feb2013

    All testing managed by Quest Diagnostics: safety, MAP testing and PK analysis.	$[****]	$[****]	 
	20-Mar-13	version8
    captures study specs discussed on 20-March with RHB.	$[****]	$[****]	 
	15-Apr-13	version9:
    

    PK analysis ([****]) done by a 3rd party located in Canada (confirmed by RHB 5-April);

    PK analysis ([****]) to be confirmed soon by RHB: testing AND validation fees as line items
    into this budget (zero quantity) - budget to be updated if QDCT eventually perform PK tissue analysis;

    validation fees( removed and to be included into the existing fully separate contract relating
    to MAP validations; 

    no changes into the transportation budget ([****]s collected at the same time than other [****]samples).	$[****]	$[****]	 
	2-Sep-13	version10
    captures the most recent decisions/information including notably the protocol amendment, approved [****],
    [****]for v, updated samples processes for Israel, US/Canada, special supplies.	$[****]	$[****]	 
	25-Sep-13	version11-
    adjusted testing/aliquoting/storage mapping.	$[****]	$[****]	 
	8-Oct-13	version
    12: Updated patients:visits distribution based on info dated 9-October (decreasing grand total number of patient-visits)	$[****]	$[****]	 
	5-Jun-14	version13:  add
    Australia and New Zealand; add estimate for optional [****]use in US only.	$[****]	$[****]	 
	14-Nov-14	version14:  

    add [****]; 

    update site numbers; 

    [****]kits, starter packs and resupplies have been updated based on study amendments; 

    Israel and [****] shipping costs from sites direct [****]have been line itemed until Quest is
    notified to begin shipping directly- budget to be updated with these costs at that time; 

    outbound shipping of cooled [****] has also been included- estimate [****] shipments per site;
    

    [****]charge included as line item;

    add [****]	$[****]	$[****]	 
	15-Jan-15	version15:

    - update site/visit/patient numbers per Patrick 19 Jan 2015,

    - addition of [****],

    - revised [****]volume of samples	$[****]	$[****]	 
	18-Jun-15	version16:

    [****] ([****] sites/[****] screen/[****] randomized)

    - remove [****] patients from US to move to [****]

    - update visit names

    - study amendment fee: update to [****]results, [****]reported as[****].  [****]Remaining
    [****] related results to be [****], add [****], AUS/NZ MAP to be sent to [****], change to PK, New kit for calprotectin collection

    - costs added for [****]

    - extend DNA storage length to 10 years	$[****]	$[****]	 

 

 

     

     

    

 

	RedHill Biopharma Limited	Quote for Services	 
	 	 	 
		Budget Summary

                                                                       Protocol: RHB-104-01 (CR)
	

 

	Study Duration:	[****]	Total Investigators: 	[****]	 
	Quote Date:	[****]	Total Countries:	[****]	 
	Quote Expiration Date:	[****]	Total Visits:	[****]	 
	 	 	Total Patient-Visits:	[****]	 

 

	Estimated
    Grand Total Amount	$[****]	 
	Average Cost
    Per Patient-Visit	$[****]	 
	Average Cost
    Per Patient 	$[****]	 

 

 

Budget Summary
1

	Sub-Totals	Region	Billing
    Amount	Conversion
    Rate	Estimated
    Total Amount
	 	USA,
    Canada	$[****]	1.0000	$[****]
	* See
    Budget Summary_EU  	Israel,
    [****], [****]	$[****]	1.0000	$[****]
	 	Australia,
    New Zealand	$[****]	1.0000	$[****]
	 	Study
    Set-up Fees	$[****]	1.0000	$[****]
	 	 	 	 	$[****]
	Average
    Cost Per Patient-Visit	Region	Estimated
    Total Amount	Patient
    Visits	Average
    Cost
	 	USA,
    Canada	$[****]	[****]	$[****]
	 	Israel,
    [****], [****]	$[****]	[****]	$[****]
	 	Australia,
    New Zealand	$[****]	[****]	$[****]
	 	Study
    Set-up Fees	$[****]	 	 
	 	 	$[****]	[****]	$[****]
	Average
    Cost Per Patient	Region	Estimated
    Total Amount	Patients	Average
    Cost
	 	USA,
    Canada	$[****]	[****]	$[****]
	 	Israel,
    [****], [****]	$[****]	[****]	$[****]
	 	Australia,
    New Zealand	$[****]	[****]	$[****]
	 	Study
    Set-up Fees	$[****]	 	 
	 	 	$[****]	270	$[****]

 

Detailed Budget
Summary

	Laboratory
    Testing	Region	Billing
    Amount	Conversion
    Rate	Estimated
    Total Amount
	 	USA, Canada	$[****]	1.0000	$[****]
	 	Israel, [****],
    [****]	$[****]	1.0000	$[****]
	 	Australia, New Zealand	$[****]	1.0000	$[****]
	Laboratory Testing Total 1LT,3LT,5LT,6LT,7LT,8LT,9LT	 	 	 	$[****]
	Supplies	Region	Billing
    Amount	Conversion
    Rate	Estimated
    Total Amount
	 	USA, Canada	$[****]	1.0000	$[****]
	 	Israel, [****],
    [****]	$[****]	1.0000	$[****]
	 	Australia, New Zealand	$[****]	1.0000	$[****]
	Supplies Total  *SL	 	 	 	$[****]
	Additional
    Pass-Through Services	Region	Billing
    Amount	Conversion
    Rate	Estimated
    Total Amount
	 	USA, Canada	$[****]	1.0000	$[****]
	 	Israel, [****],
    [****]	$[****]	1.0000	$[****]
	 	Australia, New Zealand	$[****]	1.0000	$[****]
	Additional Pass-Through Services
    Total	 	 	 	$[****]
	Storage	Region	Billing
    Amount	Conversion
    Rate	Estimated
    Total Amount
	 	USA, Canada	$[****]	1.0000	$[****]
	 	Israel, [****],
    [****]	$[****]	1.0000	$[****]
	 	Australia, New Zealand	$[****]	1.0000	$[****]
	Storage Total  1ST,2ST,3ST	 	 	 	$[****]
	Study
    Management	Region	Billing
    Amount	Conversion
    Rate	Estimated
    Total Amount
	 	USA, Canada	$[****]	1.0000	$[****]
	 	Israel, [****],
    [****]	$[****]	1.0000	$[****]
	 	Australia, New Zealand	$[****]	1.0000	$[****]
	 	Study Set-up Fees	$[****]	1.0000	$[****]
	Study Management Total  1SM,2SM,3SM,4SM,5SM,6SM,7SM,8SM	 	 	 	$[****]
	Inbound
    Transportation	Region	Billing
    Amount	Conversion
    Rate	Estimated
    Total Amount
	 	USA, Canada	$[****]	1.0000	$[****]
	 	Israel, [****],
    [****]	$[****]	1.0000	$[****]
	 	Australia, New Zealand	$[****]	1.0000	$[****]
	Inbound Transportation Total  1IT,2IT,3IT,**	 	 	 	$[****]
	Inbound
    Batched Shipments	Region	Billing
    Amount	Conversion
    Rate	Estimated
    Total Amount
	 	USA, Canada	$[****]	1.0000	$[****]
	 	Israel, [****],
    [****]	$[****]	1.0000	$[****]
	 	Australia, New Zealand	$[****]	1.0000	$[****]
	Inbound Batched Shipments Total  1IT,2IT,3IT,***	 	 	 	$[****]
	Outbound
    Transportation	Region	Billing
    Amount	Conversion
    Rate	Estimated
    Total Amount
	 	USA, Canada	$[****]	1.0000	$[****]
	 	Israel,[****], [****]	$[****]	1.0000	$[****]
	 	Australia, New Zealand	$[****]	1.0000	$[****]
	Outbound Transportation Total  1OT,2OT,3OT,4OT,5OT,6OT,7OT	 	 	 	$[****]
	Shipping
    Container Transportation	Region	Billing
    Amount	Conversion
    Rate	Estimated
    Total Amount
	 	USA, Canada	$[****]	1.0000	$[****]
	 	Israel, [****],
    [****]	$[****]	1.0000	$[****]
	Shipping
    Container Transportation Total  5OT,6OT,7OT	 	 	 	$[****]

 

     

     

    

 

	Fee
    Type                  	Israel	[****]	[****]	Total
    EU
	Laboratory
    Testing	$[****]	$[****]	$[****]	$[****]
	Supplies                  	$[****]	$[****]	$[****]	$[****]
	Special
    Services                       	$[****]	$[****]	$[****]	$[****]
	Study
    Management	$[****]	$[****]	$[****]	$[****]
	Storage
    & Services                        	$[****]	$[****]	$[****]	$[****]
	Inbound
    Transportation	$[****]	$[****]	$[****]	$[****]
	Batched
    Inbound	$[****]	$[****]	$[****]	$[****]
	Outbound
    Transportation	$[****]	$[****]	$[****]	$[****]
	Outbound
    Transportation - Shipping Containers	$[****]	$[****]	$[****]	$[****]
	Estimated
    Central Laboratory Budget:	$[****]	$[****]	$[****]	$[****]

 

 

     

     

    

 

	RedHill Biopharma Limited	Quote for Services	 
	 	 	 
		Detail Summary

                                                                       Protocol: RHB-104-01 (CR)
	

 

	Laboratory
    Testing	Region	Time
    Points	Quantity	Billing

    Currency

    Unit Price	Billing
    Amount	Conversion
    Rate	Estimated
    Total Amount	Previous
    Quantity	Previous
    Billing

    Currency

    Unit Price	Previous
    Estimated Total Amount	Estimated
    Total Variance
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	TBD	TBD	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	1	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	Laboratory Testing Total	 	 	 	 	 	 	$[****]	 	 	$[****]	$[****]
	Supplies	Region	Unit	Quantity	Billing

    Currency

    Unit Price	Billing

    Amount	Conversion
    Rate	Estimated
    Total Amount	Previous
    Quantity	Previous
    Billing

    Currency

    Unit Price	Previous
    Estimated Total Amount	Estimated
    Total Variance
	[****]	USA, Canada	CASE	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	CASE	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	BOX	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	CASE	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	PACK	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	EACH	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	Supplies Total	 	 	 	 	 	 	$[****]	 	 	$[****]	$[****]
	Additional
    Pass-Through Services	Region	Unit	Quantity	Billing

    Currency

    Unit Price	Billing

    Amount	Conversion
    Rate	Estimated
    Total Amount	Previous
    Quantity	Previous
    Billing

    Currency

    Unit Price	Previous
    Estimated Total Amount	Estimated
    Total Variance
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	Additional
    Pass-Through Services	Region	Unit	Quantity	Billing

    Currency

    Unit Price	Billing

    Amount	Conversion
    Rate	Estimated
    Total Amount	Previous
    Quantity	Previous
    Billing

    Currency

    Unit Price	Previous
    Estimated Total Amount	Estimated
    Total Variance
	[****]	 	 	[****]	 	 	 	 	 	 	 	 
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	Additional Pass-Through
    Services Total	 	 	 	 	 	 	$[****]	 	 	$[****]	$[****]
	Storage	Region	Aliquots	Quantity	Billing

    Currency

    Unit Price	Billing

    Amount	Conversion
    Rate	Estimated
    Total Amount	Previous
    Quantity	Previous
    Billing

    Currency

    Unit Price	Previous
    Estimated Total Amount	Estimated
    Total Variance
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	Storage	Region	Aliquots	Quantity	Billing

    Currency

    Unit Price	Billing

    Amount	Conversion
    Rate	Estimated
    Total Amount	Previous
    Quantity	Previous
    Billing

    Currency

    Unit Price	Previous
    Estimated Total Amount	Estimated
    Total Variance
	[****]	Israel, [****], [****]	[****]	413	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	9,499	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	413	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	922	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	Line Item	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	922	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	121	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	Line Item	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	121	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	Line Item	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	1,219	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	6,307	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	6,307	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	669	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	15,387	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	669	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	669	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	79,611	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	669	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	669	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	79,611	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	669	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	262	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	31,178	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	262	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	262	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	31,178	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	262	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	931	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	931	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	931	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	53	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	262	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	262	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	922	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	922	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	922	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	121	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	121	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	[****]	121	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	Storage	Region	Aliquots	Quantity	Billing

    Currency

    Unit Price	Billing

    Amount	Conversion
    Rate	Estimated
    Total Amount	Previous
    Quantity	Previous
    Billing

    Currency

    Unit Price	Previous
    Estimated Total Amount	Estimated
    Total Variance
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	[****]	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	Storage Total	 	 	 	 	 	 	$[****]	 	 	$[****]	$[****]
	Study
    Management	Region	Unit	Quantity	Billing

    Currency

    Unit Price	Billing

    Amount	Conversion
    Rate	Estimated
    Total Amount	Previous
    Quantity	Previous
    Billing

    Currency

    Unit Price	Previous
    Estimated Total Amount	Estimated
    Total Variance
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Study Set-up Fees	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Study Set-up Fees	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Study Set-up Fees	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Study Set-up Fees	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	Study Management Total	 	 	 	 	 	 	$[****]	 	 	$[****]	$[****]
	Inbound
    Transportation	Region	Unit	Quantity	Billing

    Currency

    Unit Price	Billing

    Amount	Conversion
    Rate	Estimated
    Total Amount	Previous
    Quantity	Previous
    Billing

    Currency

    Unit Price	Previous
    Estimated Total Amount	Estimated
    Total Variance
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	Inbound Transportation
    Total	 	 	 	 	 	 	$[****]	 	 	$[****]	$[****]
	Inbound
    Batched Shipments	Region	Unit	Quantity	Billing

    Currency

    Unit Price	Billing

    Amount	Conversion
    Rate	Estimated
    Total Amount	Previous
    Quantity	Previous
    Billing

    Currency

    Unit Price	Previous
    Estimated Total Amount	Estimated
    Total Variance
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	Inbound Batched Shipments
    Total	 	 	 	 	 	 	$[****]	 	 	$[****]	$[****]
	Outbound
    Transportation	Region	Unit	Quantity	Billing

    Currency

    Unit Price	Billing

    Amount	Conversion
    Rate	Estimated
    Total Amount	Previous
    Quantity	Previous
    Billing

    Currency

    Unit Price	Previous
    Estimated Total Amount	Estimated
    Total Variance
	[****]	USA, Canada	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	[****]	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Australia, New Zealand	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	Outbound Transportation
    Total	 	 	 	 	 	 	$[****]	 	 	$[****]	$[****]
	Shipping
    Container Transportation	Region	Unit	Quantity	Billing

    Currency

    Unit Price	Billing

    Amount	Conversion
    Rate	Estimated
    Total Amount	Previous
    Quantity	Previous
    Billing

    Currency

    Unit Price	Previous
    Estimated Total Amount	Estimated
    Total Variance
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	USA, Canada	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	[****]	Israel, [****], [****]	 	[****]	$[****]	$[****]	1.0000	$[****]	[****]	$[****]	$[****]	$[****]
	Shipping Container Transportation
    Total	 	 	 	 	 	 	$[****]	 	 	$[****]	$[****]

 

     

     

    

 

	RedHill Biopharma Limited	Quote for Services	 
	 	 	 
		Test Visit Schedule

                                                                                               All Locations

                                                                       Protocol: RHB-104-01 (CR)
	

 

 

 

 

 

 

 

[****]

 

     

     

    

 

	RedHill Biopharma Limited	Quote for Services	 
	 	 	 
		Patient Visit Schedule

                                                                                               All Locations

                                                                       Protocol: RHB-104-01 (CR)
	

 

 

 

	Country	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	Calculated Totals:	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	 	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	Canada (Toronto)	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	United States (New York)	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	Israel (Tel Aviv)	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	Israel (Tel Aviv) - sites direct to [****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	Canada (Toronto) - sites direct to [****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	United States (New York) - sites direct to
    [****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	Australia ([****])	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	Australia ([****]) - sites direct to [****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	New Zealand ([****])	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	New Zealand ([****]) - [****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]
	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]	[****]

 

     

     

    

 

 

	RedHill Biopharma Limited	Quote for Services	 
	 	 	 
		End Notes

                                                                       Protocol: RHB-104-01 (CR)
	

 

	Global Summary
	1	See Study Specific Assumptions and Pricing Model, herein.  Budget excludes any “TBD” (To Be Determined) items.
	Global Summary - Laboratory Testing (LT)
	1LT	Quoted fees reflect Q2 Solutions', a Quintiles Quest Joint Venture, Year 2011 Fee Schedule.
	2LT	Referral test to be performed by UFC. Fee includes the referral laboratory charge plus a referral fee for sample handling, data entry and result reporting. Any fee increase imposed by the Referral laboratory will be passed on to Client.
	3LT	Fees quoted for testing services performed are exclusive of any applicable added Taxes (including Value Added Tax (VAT)).
	4LT	Test to be performed by our alliance partner laboratory, Tan Tock Seng, in Singapore.
	5LT	The sample testing fees include the receipt of samples into a Q2 Solutions, a Quintiles Quest Joint Venture, -owned, affiliate or alliance partner laboratory, the direct costs associated with the laboratory testing of the samples, retention of the unused samples for a maximum of fourteen (14) days, laboratory quality control and global standardisation of equipment, processes, controls and calibrators.  
	6LT	The sample testing fees also include the distribution of interim result reports (per patient visit) and final result reports to Investigator(s) and/or Clients/CROs as applicable and agreed in the Central Laboratory Worksheet.  Any final result reports issued in hard copy will be sent via standard postal service or (within the continental United States only)  Q2 Solutions, a Quintiles Quest Joint Venture, -US proprietary courier.
	7LT	It is Q2 Solutions', a Quintiles Quest Joint Venture, experience that  investigator sites experience significant challenges producing a peripheral blood smear ( PBS )  of sufficient quality for an appropriate hematology laboratory PBS review. Therefore, it is standard Q2 Solutions', a Quintiles Quest Joint Venture, practice to not provide glass slides and to not require the sites to make PBS slides . The performance by Q2 Solutions, a Quintiles Quest Joint Venture, of a routine safety CBC analysis (hematology) does involve the occasional review of PBS slides for the white blood cell morphology and differential, red blood cell morphology and platelet evaluation if the instrument or the SOP flags the specimen for a PBS slide review. The PBS slide can be appropriately created and reviewed in the majority of cases by the laboratory from the submitted CBC sample if a review is required.  
	8LT	If the protocol requires a PBS slide review then glass microscope slides will be provided to the site(s) for each appropriate visit so that the site can create and provide a PBS to the central laboratory. Protocols where in our experience peripheral blood smears are recommended include significant hematological/bone marrow abnormalities (white or red cell, platelet abnormalities), leukaemia's, HIV clinical trials, sepsis, or other severe illnesses that would be impacting the hematological system. Our scientific affairs and medical affairs teams are available to further discuss the needs of your protocol regarding any requirements for PBS creation by the site or by the laboratory and PBS slide review by the Quest laboratory. Please could you confirm if this protocol requires a peripheral blood smear review or if subjects in this study are expected  to have hematological abnormalities where we would recommend the preparation of peripheral blood smears at the investigator site.
	9LT	CBC and Peripheral blood smear pricing are based on assumptions received at the point of preparing this quotation.  Q2 Solutions, a Quintiles Quest Joint Venture, reserves the right to adjust these pertinent to further discussion with the customer.
	Global Summary - Supplies
    (SL)
	*	The Supplies total for shipping containers is based on one separate shipment for each patient visit and reflects a “worst case scenario.”  Shipper container costs may be dramatically reduced when sites batch specimens prior to shipment to the laboratory.
	Global Summary - Storage (ST)
	1ST	The “In” fee includes receipt, preparation, storage and entry of specimens into Q2 Solutions, a Quintiles Quest Joint Venture storage facility and computer system.
	2ST	The “Monthly Maintenance” fee includes inventory, storage, temperature monitoring and continuous security coverage at Q2 Solutions, a Quintiles Quest Joint Venture storage facility.
	3ST	The “Pull” fee includes the removal of requested specimens from storage, sorting of specimens prior to shipment (in a manner requested by client, e.g. - by patient, by visit) and the generation of a manifest.
	Global Summary - Study Management
    (SM)
	1SM	The Study Management set-up fees quoted include provision for our standard toxicity and exclusions flagging; and cumulative data transmissions sent weekly via email zip file or SFTP or portals in our standard data file format. The fees do not include any set-up related to storage samples, new testing method set-up's, algorithms, microbiology testing or referral lab data entry. If client requires Q2 Solutions, a Quintiles Quest Joint Venture, to add any of these elements or set up additional flagging options and use data files which differ to our standard format, we reserve the right to adjust our set-up fees accordingly.
	2SM	The Project Management Study Set-Up fee includes an internal review of the protocol in conjunction with the client's study team and formulation of an agreed Central Laboratory Worksheet signed off by Client and Q2 Solutions, a Quintiles Quest Joint Venture, which lays out detailed specifications for the set-up and management of the study. Q2 Solutions, a Quintiles Quest Joint Venture, will design study documents, which include Investigator Manuals in the languages specified in the budget, a Lab Requirement Summary and pictogram, and study specific test Requistion forms in accordance with these specifications, as part of this fee. The design of visit specific specimen collection kits and set-up of Investigator site information is included as part of Project Management set-up.
	3SM	The fee Per Visit for Project Management covers ongoing Project Management support, 24/7 investigator assistance/support by Q2 Solutions, a Quintiles Quest Joint Venture, CRC Support Team, including the use of toll-free phone lines.  Auto faxing of supply expiry details and inclusion of alerts and delta flagging are also covered by this fee.
	4SM	The fee Per Visit for Data Management covers ongoing Data Management support, maintenance of the results database and the actioning and documentation of all necessary data revisions and data transfers up to once per week.
	5SM	The fee Per Visit for Logistics covers the expertise and management of the ongoing study logistics, shipment tracking, processing and auditing of courier invoices and the performance management of the courier companies.
	6SM	Q2 Solutions, a Quintiles Quest Joint Venture, proprietary software Result/ViewTM – web-based version shall be included for the two users per study at no additional charge, more than two users will be charged. This includes training and support by telephone.
	7SM	Q2 Solutions, a Quintiles Quest Joint Venture will charge a per work order fee associated with each pull order. The purpose of this is to maximize the batching of samples whenever they are pulled for regular or ad hoc shipments from sample storage in order to create operational efficiency.
	8SM	Q2 Solutions, a Quintiles Quest Joint Venture will charge a STAT per work order fee associated with each STAT pull order request. The purpose of this charge is for STAT pull order requests needed in 5 business days or less.

	Global Summary - Inbound Transportation
    (IT)
	**	The Inbound Transportation total is representative of individual patient specimen shipments and reflects a “worst case scenario”.  Transportation totals may be dramatically reduced when sites batch specimens prior to shipment to the laboratory. Please note if India, Russia and the Ukraine are participating in the study those countries dry ice and packaging fees are included in the inbound charges.
	***	The Total Batched Inbound Transportation is representative of 24 batched shipments per site for frozen samples. Please note if India, Russia and the Ukraine are participating in the study those countries dry ice and packaging fees are included in the inbound charges.
	1IT	The inbound specimen transportation fees are based on typical volumetric weight, and vary by city.  Q2 Solutions, a Quintiles Quest Joint Venture will bill client actual transport costs, per the invoice of the transport company. Any change to the fee imposed by the courier will be passed on to client. Additional charges for secondary cities, holidays and weekend service may apply. 
	2IT	The USD ($) Inbound Diagnostic Transportation fees quoted are based on an estimated exchange rate of £1 GBP = $ 1.6022. However, all Inbound Diagnostic Transportation will be billed at the actual £GBP to USD ($) rate ruling in the applicable month as published by UK Customs and Excise. Thus the Inbound Transportation fees may vary from those quoted in this budget in any given month depending on what the actual exchange rate is.
	3IT	The Logistics estimates included represent our best recommendations based on recent experience.  We welcome the opportunity to discuss carrier performance and recommendations since the decision on courier selection ultimately resides with the sponsor.
	Global Summary - Outbound
    Transportation (OT)
	1OT	Initial Supply Shipments: Initial shipments will be distributed within ten (10) working days from Client’s approval of the (a) requisition form, (b) Investigator Manual, and (c) receipt of Client’s final Investigator list. Q2 Solutions, a Quintiles Quest Joint Venture, must also receive Client’s approval of Q2 Solutions', a Quintiles Quest Joint Venture, verification report (without changes) at least 2 days prior to shipment.
	2OT	Please note that Q2 Solutions, a Quintiles Quest Joint Venture does charge an additional fee for expedited/priority starter pack shipments.
	3OT	Shipment of Re-supplies: Re-supply orders will be distributed within five (5) working days of Q2 Solutions', a Quintiles Quest Joint Venture, receipt of the Request for Supplies form from the Investigator or Client. Any re-supply orders containing special supplies shall be shipped upon supply availability and may require more than a five (5) working day turnaround.
	4OT	Q2 Solutions, a Quintiles Quest Joint Venture, will use commercially-reasonable efforts to provide re-supply orders with less than five (5) working-days prior notification from Client or the Investigator (“STAT re-orders”).  However, Client will be responsible for all additional labor and transportation charges associated with STAT re-orders.
	5OT	The Outbound transportation fees are based on typical volumetric weight.  Q2 Solutions, a Quintiles Quest Joint Venture will bill client actual transport costs per the invoice of the transport company.  Any change to the fee imposed by the courier will be passed on to client.  Priority shipments, e.g. next-day air are additional.  Fees for outbound supply shipments do not include any imposed tariffs.  
	6OT	The USD ($) Outbound transportation fees quoted are based on an estimated exchange rate of £1 GBP = $ 1.6022. However, all Outbound Transportation will be billed at the actual £GBP to USD ($) rate ruling in the applicable month as published by UK Customs and Excise. Thus the actual Outbound Transportation fees may vary from those quoted in this budget in any given month depending on what the actual exchange rate is.
	7OT	The Logistics estimates included represent our best recommendations based on recent experience.  We welcome the opportunity to discuss carrier performance and recommendations since the decision on courier selection ultimately resides with the sponsor.Exhibit 4.22

 

THE SYMBOL "[****]" DENOTES PLACES WHERE PORTIONS OF THIS DOCUMENT HAVE
BEEN OMIITTED PURSUANT TO A REQUEST FOR CONFIDENTIAL TREATMENT. SUCH MATERIAL HAS BEEN FILED SEPARATELY WITH THE SECURITIES AND
EXCHANGE COMMISSION 

 

 

REDHILL
BIOPHARMA LTD

Change
Specification Form

(Q2Solutions,
a Quintiles Quest Joint Venture)

	Protocol:	Requester:
	RHB-104-01	Patrick McLean
	Proposed
    date 	Project
    Manager(s):	Date
    of Request: 17-Jun-15 
	of Implementation:	Fitt,Penny	Request
    Reference – Title: US-9182
	6 weeks from approval	KLINGLER, MARIANA	 
	Original
    Specifications (if applicable):
	N/A
	Change
    in Specifications/New Specifications:
	Addition of [****]. [****] sites, [****] patients randomized in one year with
the first patient in [****], [****]. We are assuming a [****] screen failure rate. This country is to follow the EU MAP process.

	 
	Please
    see details of changes : 
	☒
    Database
	☒
    Addition of investigator site (Per site) [****]
	☒
    Investigator Manual
	☒
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    Amendment Fee: $ [****] for account 64160601 (US)
	This Change Specification Form includes the cost of the amendment fee associated with the above noted change(s). The amendment budget will include any additional supply, testing, or transportation charges incurred as a result of these changes.

 

Comments

 

Reviewer’s Name:

	Signature:	/s/ Uri Hananel Aharon, CAO	 	Date: 	Sep. 17, 2015 	 
	 	 	 	 	 	 
	Signature:	/s/ Ori Shilo, Deputy CEO	 	Date: 	Sep. 17, 2015

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