Document:

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                                  EXHIBIT 10.5

                             ADVANCED MEDICINE, INC.

                          EMPLOYEE STOCK PURCHASE PLAN

                         (AS ADOPTED FEBRUARY 26, 2000)

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                                TABLE OF CONTENTS
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SECTION 1.  PURPOSE OF THE PLAN...................................................................................1

SECTION 2.  ADMINISTRATION OF THE PLAN............................................................................1
         (a)  Committee Composition...............................................................................1
         (b)  Committee Responsibilities..........................................................................1

SECTION 3.  ENROLLMENT AND PARTICIPATION..........................................................................1
         (a)  Offering Periods....................................................................................1
         (b)  Accumulation Periods................................................................................1
         (c)  Enrollment..........................................................................................1
         (d)  Duration of Participation...........................................................................2
         (e)  Applicable Offering Period..........................................................................2

SECTION 4.  EMPLOYEE CONTRIBUTIONS................................................................................2
         (a)  Frequency of Payroll Deductions.....................................................................2
         (b)  Amount of Payroll Deductions........................................................................2
         (c)  Changing Withholding Rate...........................................................................3
         (d)  Discontinuing Payroll Deductions....................................................................3
         (e)  Limit on Number of Elections........................................................................3

SECTION 5.  WITHDRAWAL FROM THE PLAN..............................................................................3
         (a)  Withdrawal..........................................................................................3
         (b)  Re-Enrollment After Withdrawal......................................................................3

SECTION 6.  CHANGE IN EMPLOYMENT STATUS...........................................................................3
         (a)  Termination of Employment...........................................................................3
         (b)  Leave of Absence....................................................................................4
         (c)  Death...............................................................................................4

SECTION 7.  PLAN ACCOUNTS AND PURCHASE OF SHARES..................................................................4
         (a)  Plan Accounts.......................................................................................4
         (b)  Purchase Price......................................................................................4
         (c)  Number of Shares Purchased..........................................................................4
         (d)  Available Shares Insufficient.......................................................................5
         (e)  Issuance of Stock...................................................................................5
         (f)  Unused Cash Balances................................................................................5
         (g)  Stockholder Approval................................................................................5

SECTION 8.  LIMITATIONS ON STOCK OWNERSHIP........................................................................5
         (a)  Five Percent Limit..................................................................................5
         (b)  Dollar Limit........................................................................................6

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SECTION 9.  RIGHTS NOT TRANSFERABLE...............................................................................6

SECTION 10.  NO RIGHTS AS AN EMPLOYEE.............................................................................6

SECTION 11.  NO RIGHTS AS A STOCKHOLDER...........................................................................7

SECTION 12.  SECURITIES LAW REQUIREMENTS..........................................................................7

SECTION 13.  STOCK OFFERED UNDER THE PLAN.........................................................................7
         (a)  Authorized Shares...................................................................................7
         (b)  Anti-Dilution Adjustments...........................................................................7
         (c)  Reorganizations.....................................................................................7

SECTION 14.  AMENDMENT OR DISCONTINUANCE..........................................................................8

SECTION 15.  DEFINITIONS..........................................................................................8
         (a)  Accumulation Period.................................................................................8
         (b)  Board...............................................................................................8
         (c)  Code................................................................................................8
         (d)  Committee...........................................................................................8
         (e)  Corporation.........................................................................................8
         (f)  Compensation........................................................................................8
         (g)  Corporate Reorganization............................................................................8
         (h)  Eligible Employee...................................................................................9
         (i)  Exchange Act........................................................................................9
         (j)  Fair Market Value...................................................................................9
         (k)  IPO.................................................................................................9
         (l)  Offering Period.....................................................................................9
         (m)  Participant........................................................................................10
         (n)  Participating Corporation..........................................................................10
         (o)  Plan...............................................................................................10
         (p)  Plan Account.......................................................................................10
         (q)  Purchase Price.....................................................................................10
         (r)  Stock..............................................................................................10
         (s)  Subsidiary.........................................................................................10

</TABLE>
                                      ii

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                             ADVANCED MEDICINE, INC.
                          EMPLOYEE STOCK PURCHASE PLAN

SECTION 1. PURPOSE OF THE PLAN.

         The Plan was adopted by the Board on February 26, 2000 to be effective
as of the date of the IPO. The purpose of the Plan is to provide Eligible
Employees with an opportunity to increase their proprietary interest in the
success of the Corporation by purchasing Stock from the Corporation on favorable
terms and to pay for such purchases through payroll deductions. The Plan is
intended to qualify under section 423 of the Code.

SECTION 2. ADMINISTRATION OF THE PLAN.

         (a) COMMITTEE COMPOSITION. The Plan shall be administered by the
Committee. The Committee shall consist exclusively of one or more directors of
the Corporation, who shall be appointed by the Board.

         (b) COMMITTEE RESPONSIBILITIES. The Committee shall interpret the Plan
and make all other policy decisions relating to the operation of the Plan. The
Committee may adopt such rules, guidelines and forms as it deems appropriate to
implement the Plan. The Committee's determinations under the Plan shall be final
and binding on all persons.

SECTION 3. ENROLLMENT AND PARTICIPATION.

         (a) OFFERING PERIODS. While the Plan is in effect, four overlapping
Offering Periods shall commence in each calendar year. The Offering Periods
shall consist of the 27-month periods commencing on each February 1, May 1,
August 1, and November 1 except that the first Offering Period shall commence on
the date of the IPO and end on July 31, 2002.

         (b) ACCUMULATION PERIODS. While the Plan is in effect, four
Accumulation Periods shall commence in each calendar year. The Accumulation
Periods shall consist of the three-month periods commencing on each February 1,
May 1, August 1 and November 1, except that the first Accumulation Period shall
commence on the date of the IPO and end on October 31, 2000.

         (c) ENROLLMENT. Any individual who, on the day preceding the first day
of an Offering Period, qualifies as an Eligible Employee may elect to become a
Participant in the Plan for such Offering Period by executing the enrollment
form prescribed for this purpose by the Committee. The enrollment form shall be
filed with the Corporation at the prescribed location on or before the start
date of such Offering Period.

         (d) DURATION OF PARTICIPATION. Once enrolled in the Plan, a Participant
shall continue to participate in the Plan until he or she ceases to be an
Eligible Employee, withdraws from the Plan under Section 5(a) or reaches the end
of the Accumulation Period in which his or

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her employee contributions were discontinued under Section 4(d) or 8(b). A
Participant who discontinued employee contributions under Section 4(d) or
withdrew from the Plan under Section 5(a) may again become a Participant, if
he or she then is an Eligible Employee, by following the procedure described
in Subsection (c) above. A Participant whose employee contributions were
discontinued automatically under Section 8(b) shall automatically resume
participation at the beginning of the earliest Accumulation Period ending in
the next calendar year, if he or she then is an Eligible Employee.

         (e) APPLICABLE OFFERING PERIOD. For purposes of calculating the
Purchase Price under Section 7(b), the applicable Offering Period shall be
determined as follows:

                  (i) Once a Participant is enrolled in the Plan for an Offering
Period, such Offering Period shall continue to apply to him or her until the
earliest of (A) the end of such Offering Period, (B) the end of his or her
participation under Subsection (d) above or (C) re-enrollment for a subsequent
Offering Period under Paragraph (ii) or (iii) below.

                  (ii) In the event that the Fair Market Value of Stock on the
last trading day before the commencement of the Offering Period for which the
Participant is enrolled is higher than on the last trading day before the
commencement of any subsequent Offering Period, the Participant shall
automatically be re-enrolled for such subsequent Offering Period.

                  (iii) Any other provision of the Plan notwithstanding, the
Corporation (at its sole discretion) may determine prior to the commencement of
any new Offering Period that all Participants shall be re-enrolled for such new
Offering Period.

                  (iv) When a Participant reaches the end of an Offering Period
but his or her participation is to continue, then such Participant shall
automatically be re-enrolled for the Offering Period that commences immediately
after the end of the prior Offering Period.

SECTION 4. EMPLOYEE CONTRIBUTIONS.

         (a) FREQUENCY OF PAYROLL DEDUCTIONS. A Participant may purchase shares
of Stock under the Plan solely by means of payroll deductions. Payroll
deductions, as designated by the Participant pursuant to Subsection (b) below,
shall occur on each payday during participation in the Plan.

         (b) AMOUNT OF PAYROLL DEDUCTIONS. An Eligible Employee shall designate
on the enrollment form the portion of his or her Compensation that he or she
elects to have withheld for the purchase of Stock. Such portion shall be a whole
percentage of the Eligible Employee's Compensation, but not less than 1% nor
more than 15%.

         (c) CHANGING WITHHOLDING RATE. If a Participant wishes to change the
rate of payroll withholding, he or she may do so by filing a new enrollment form
with the Corporation at the prescribed location at any time. The new withholding
rate shall be effective as soon as reasonably practicable after such form has
been received by the Corporation. The new withholding rate shall be a whole
percentage of the Eligible Employee's Compensation, but not less than 1% nor
more than 15%.

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         (d) DISCONTINUING PAYROLL DEDUCTIONS. If a Participant wishes to
discontinue employee contributions entirely, he or she may do so by filing a new
enrollment form with the Corporation at the prescribed location at any time.
Payroll withholding shall cease as soon as reasonably practicable after such
form has been received by the Corporation. (In addition, employee contributions
may be discontinued automatically pursuant to Section 8(b).) A Participant who
has discontinued employee contributions may resume such contributions by filing
a new enrollment form with the Corporation at the prescribed location. Payroll
withholding shall resume as soon as reasonably practicable after such form has
been received by the Corporation.

         (e) LIMIT ON NUMBER OF ELECTIONS. No Participant shall make more than 2
elections under Subsection (c) or (d) above during any Accumulation Period.

SECTION 5. WITHDRAWAL FROM THE PLAN.

         (a) WITHDRAWAL. A Participant may elect to withdraw from the Plan by
filing the prescribed form with the Corporation at the prescribed location at
any time before the last day of an Accumulation Period. As soon as reasonably
practicable thereafter, payroll deductions shall cease and the entire amount
credited to the Participant's Plan Account shall be refunded to him or her in
cash, without interest. No partial withdrawals shall be permitted.

         (b) RE-ENROLLMENT AFTER WITHDRAWAL. A former Participant who has
withdrawn from the Plan shall not be a Participant until he or she re-enrolls in
the Plan under Section 3(c). Re-enrollment may be effective only at the
commencement of an Offering Period.

SECTION 6. CHANGE IN EMPLOYMENT STATUS.

         (a) TERMINATION OF EMPLOYMENT. Termination of employment as an Eligible
Employee for any reason, including death, shall be treated as an automatic
withdrawal from the Plan under Section 5(a). (A transfer from one Participating
Corporation to another shall not be treated as a termination of employment.)

         (b) LEAVE OF ABSENCE. For purposes of the Plan, employment shall not be
deemed to terminate when the Participant goes on a military leave, a sick leave
or another BONA FIDE leave of absence, if the leave was approved by the
Corporation in writing. Employment, however, shall be deemed to terminate 90
days after the Participant goes on a leave, unless a contract or statute
guarantees his or her right to return to work. Employment shall be deemed to
terminate in any event when the approved leave ends, unless the Participant
immediately returns to work.

         (c) DEATH. In the event of the Participant's death, the amount credited
to his or her Plan Account shall be paid to a beneficiary designated by him or
her for this purpose on the prescribed form or, if none, to the Participant's
estate. Such form shall be valid only if it was filed with the Corporation at
the prescribed location before the Participant's death.

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SECTION 7. PLAN ACCOUNTS AND PURCHASE OF SHARES.

         (a) PLAN ACCOUNTS. The Corporation shall maintain a Plan Account on its
books in the name of each Participant. Whenever an amount is deducted from the
Participant's Compensation under the Plan, such amount shall be credited to the
Participant's Plan Account. Amounts credited to Plan Accounts shall not be trust
funds and may be commingled with the Corporation's general assets and applied to
general corporate purposes. No interest shall be credited to Plan Accounts.

         (b) PURCHASE PRICE. The Purchase Price for each share of Stock
purchased at the close of an Accumulation Period shall be the lower of:

                  (i) 85% of the Fair Market Value of such share on the last
trading day in such Accumulation Period; or

                  (ii) 85% of the Fair Market Value of such share on the last
trading day before the commencement of the applicable Offering Period (as
determined under Section 3(e)) or, in the case of the first Offering Period
under the Plan, the lower of: (A) 85% of the price at which one share of Stock
is offered to the public in the IPO; or (B) 85% of the Fair Market Value of such
share on the purchase date.

         (c) NUMBER OF SHARES PURCHASED. As of the last day of each Accumulation
Period, each Participant shall be deemed to have elected to purchase the number
of shares of Stock calculated in accordance with this Subsection (c), unless the
Participant has previously elected to withdraw from the Plan in accordance with
Section 5(a). The amount then in the Participant's Plan Account shall be divided
by the Purchase Price, and the number of shares that results shall be purchased
from the Corporation with the funds in the Participant's Plan Account. The
foregoing notwithstanding, no Participant shall purchase more than 2,500 shares
of Stock with respect to any Accumulation Period or more than the amounts of
Stock set forth in Sections 8(b) and 13(a). The Committee may determine with
respect to all Participants that any fractional share, as calculated under this
Subsection (c), shall be (i) rounded down to the next lower whole share or (ii)
credited as a fractional share.

         (d) AVAILABLE SHARES INSUFFICIENT. In the event that the aggregate
number of shares that all Participants elect to purchase during an Accumulation
Period exceeds the maximum number of shares remaining available for issuance
under Section 13(a), then the number of shares to which each Participant is
entitled shall be determined by multiplying the number of shares available for
issuance by a fraction, the numerator of which is the number of shares that such
Participant has elected to purchase and the denominator of which is the number
of shares that all Participants have elected to purchase.

         (e) ISSUANCE OF STOCK. Certificates representing the shares of Stock
purchased by a Participant under the Plan shall be issued to him or her as soon
as reasonably practicable after the close of the applicable Accumulation Period,
except that the Committee may determine that such shares shall be held for each
Participant's benefit by a broker designated by the Committee (unless the
Participant has elected that certificates be issued to him or her). Shares may
be

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registered in the name of the Participant or jointly in the name of the
Participant and his or her spouse as joint tenants with right of survivorship
or as community property.

         (f) UNUSED CASH BALANCES. An amount remaining in the Participant's Plan
Account that represents the Purchase Price for any fractional share shall be
carried over in the Participant's Plan Account to the next Accumulation Period.
Any amount remaining in the Participant's Plan Account that represents the
Purchase Price for whole shares that could not be purchased by reason of
Subsection (c) above, Section 8(b) or Section 13(a) shall be refunded to the
Participant in cash, without interest.

         (g) STOCKHOLDER APPROVAL. Any other provision of the Plan
notwithstanding, no shares of Stock shall be purchased under the Plan unless and
until the Corporation's stockholders have approved the adoption of the Plan.

SECTION 8. LIMITATIONS ON STOCK OWNERSHIP.

         (a) FIVE PERCENT LIMIT. Any other provision of the Plan
notwithstanding, no Participant shall be granted a right to purchase Stock under
the Plan if such Participant, immediately after his or her election to purchase
such Stock, would own stock possessing more than 5% of the total combined voting
power or value of all classes of stock of the Corporation or any parent or
Subsidiary of the Corporation. For purposes of this Subsection (a), the
following rules shall apply:

                  (i) Ownership of stock shall be determined after applying the
attribution rules of section 424(d) of the Code;

                  (ii) Each Participant shall be deemed to own any stock that he
or she has a right or option to purchase under this or any other plan; and

                  (iii) Each Participant shall be deemed to have the right to
purchase 2,500 shares of Stock under this Plan with respect to each Accumulation
Period.

         (b) DOLLAR LIMIT. Any other provision of the Plan notwithstanding, no
Participant shall purchase Stock with a Fair Market Value in excess of the
following limit:

                  (i) In the case of Stock purchased during an Offering Period
that commenced in the current calendar year, the limit shall be equal to (A)
$25,000 minus (B) the Fair Market Value of the Stock that the Participant
previously purchased in the current calendar year (under this Plan and all other
employee stock purchase plans of the Corporation or any parent or Subsidiary of
the Corporation).

                  (ii) In the case of Stock purchased during an Offering Period
that commenced in the immediately preceding calendar year, the limit shall be
equal to (A) $50,000 minus (B) the Fair Market Value of the Stock that the
Participant previously purchased (under this Plan and all other employee stock
purchase plans of the Corporation or any parent or Subsidiary of the
Corporation) in the current calendar year and in the immediately preceding
calendar year.

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                  (iii) In the case of Stock purchased during an Offering Period
that commenced in the second preceding calendar year, the limit shall be equal
to (A) $75,000 minus (B) the Fair Market Value of the Stock that the Participant
previously purchased (under this Plan and all other employee stock purchase
plans of the Corporation or any parent or Subsidiary of the Corporation) in the
current calendar year and in the two preceding calendar years.

         For purposes of this Subsection (b), the Fair Market Value of Stock
shall be determined in each case as of the beginning of the Offering Period in
which such Stock is purchased. Employee stock purchase plans not described in
section 423 of the Code shall be disregarded. If a Participant is precluded by
this Subsection (b) from purchasing additional Stock under the Plan, then his or
her employee contributions shall automatically be discontinued and shall resume
at the beginning of the earliest Accumulation Period ending in the next calendar
year (if he or she then is an Eligible Employee).

SECTION 9. RIGHTS NOT TRANSFERABLE.

         The rights of any Participant under the Plan, or any Participant's
interest in any Stock or moneys to which he or she may be entitled under the
Plan, shall not be transferable by voluntary or involuntary assignment or by
operation of law, or in any other manner other than by beneficiary designation
or the laws of descent and distribution. If a Participant in any manner attempts
to transfer, assign or otherwise encumber his or her rights or interest under
the Plan, other than by beneficiary designation or the laws of descent and
distribution, then such act shall be treated as an election by the Participant
to withdraw from the Plan under Section 5(a).

SECTION 10. NO RIGHTS AS AN EMPLOYEE.

         Nothing in the Plan or in any right granted under the Plan shall confer
upon the Participant any right to continue in the employ of a Participating
Corporation for any period of specific duration or interfere with or otherwise
restrict in any way the rights of the Participating Companies or of the
Participant, which rights are hereby expressly reserved by each, to terminate
his or her employment at any time and for any reason, with or without cause.

SECTION 11. NO RIGHTS AS A STOCKHOLDER.

         A Participant shall have no rights as a stockholder with respect to any
shares of Stock that he or she may have a right to purchase under the Plan until
such shares have been purchased on the last day of the applicable Accumulation
Period.

SECTION 12. SECURITIES LAW REQUIREMENTS.

         Shares of Stock shall not be issued under the Plan unless the issuance
and delivery of such shares comply with (or are exempt from) all applicable
requirements of law, including (without limitation) the Securities Act of 1933,
as amended, the rules and regulations promulgated thereunder, state securities
laws and regulations, and the regulations of any stock exchange or other
securities market on which the Corporation's securities may then be traded.
The issuance of Stock under this Plan may be conditioned on the Participant's
agreement to be bound by an agreement between the Company and its
underwriters prohibiting resale of the shares of Stock.

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SECTION 13. STOCK OFFERED UNDER THE PLAN.

         (a) AUTHORIZED SHARES. The number of shares of Stock available for
purchase under the Plan shall be 750,000 (subject to adjustment pursuant to this
Section 13). On January 1 of each year, commencing with January 1, 2001, the
aggregate number of shares of Stock available for purchase during the life of
the Plan shall automatically be increased by the lesser of 0.5% of the total
number of shares of Common Stock then outstanding, or 500,000 shares (subject to
adjustment pursuant to this Section 13).

         (b) ANTI-DILUTION ADJUSTMENTS. The aggregate number of shares of Stock
offered under the Plan, the 2,500 share limitation described in Section 7(c),
the 750,000-share limitation described in Section 13(a), the 500,000 share
limitation on annual increases, and the price of shares that any Participant has
elected to purchase shall be adjusted proportionately by the Committee for any
increase or decrease in the number of outstanding shares of Stock resulting from
a subdivision or consolidation of shares or the payment of a stock dividend, any
other increase or decrease in such shares effected without receipt or payment of
consideration by the Corporation, the distribution of the shares of a Subsidiary
to the Corporation's stockholders or a similar event.

         (c) REORGANIZATIONS. Any other provision of the Plan notwithstanding,
immediately prior to the effective time of a Corporate Reorganization, the
Offering Period(s) and Accumulation Period(s) then in progress shall terminate
and shares shall be purchased pursuant to Section 7, unless the Plan is
continued or assumed by the surviving corporation or its parent corporation. The
Plan shall in no event be construed to restrict in any way the Corporation's
right to undertake a dissolution, liquidation, merger, consolidation or other
reorganization.

SECTION 14. AMENDMENT OR DISCONTINUANCE.

         The Board shall have the right to amend, suspend or terminate the Plan
at any time and without notice. The Corporation's Chief Executive Officer may
also amend the Plan to the extent allowable under applicable law to effect
non-material amendments. Except as provided in Section 13, any increase in the
aggregate number of shares of Stock to be issued under the Plan shall be subject
to approval by a vote of the stockholders of the Corporation. In addition, any
other amendment of the Plan shall be subject to approval by a vote of the
stockholders of the Corporation to the extent required by an applicable law or
regulation.

SECTION 15. DEFINITIONS.

         (a) "ACCUMULATION PERIOD" means a three-month period during which
contributions may be made toward the purchase of Stock under the Plan, as
determined pursuant to Section 3(b).

         (b) "BOARD" means the Board of Directors of the Corporation, as
constituted from time to time.

         (c) "CODE" means the Internal Revenue Code of 1986, as amended.

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         (d) "COMMITTEE" means a committee of the Board, as described in
Section 2.

         (e) "CORPORATION" means Advanced Medicine, Inc., a Delaware
corporation.

         (f) "COMPENSATION" means (i) the total compensation paid in cash to a
Participant by a Participating Corporation, including salaries, wages, bonuses,
incentive compensation, commissions, overtime pay and shift premiums, plus (ii)
any pre-tax contributions made by the Participant under section 401(k) or 125 of
the Code. "Compensation" shall exclude all non-cash items, moving or relocation
allowances, cost-of-living equalization payments, car allowances, tuition
reimbursements, imputed income attributable to cars or life insurance, severance
pay, fringe benefits, contributions or benefits received under employee benefit
plans, income attributable to the exercise of stock options, and similar items.
The Committee shall determine whether a particular item is included in
Compensation.

         (g) "CORPORATE REORGANIZATION" means:

                  (i) The consummation of a merger or consolidation of the
Corporation with or into another entity or any other corporate reorganization;
or

                  (ii) The sale, transfer or other disposition of all or
substantially all of the Corporation's assets or the complete liquidation or
dissolution of the Corporation.

         (h) "ELIGIBLE EMPLOYEE" means any employee of a Participating
Corporation who meets both of the following requirements:

                  (i) His or her customary employment is for more than five
months per calendar year and for more than 20 hours per week; and

                  (ii) He or she has been an employee of a Participating
Corporation for not less than five consecutive months.

         The foregoing notwithstanding, an individual shall not be considered an
Eligible Employee if his or her participation in the Plan is prohibited by the
law of any country which has jurisdiction over him or her or if he or she is
subject to a collective bargaining agreement that does not provide for
participation in the Plan.

         (i) "EXCHANGE ACT" means the Securities Exchange Act of 1934, as
amended.

         (j) "FAIR MARKET VALUE" means the market price of Stock, determined by
the Committee as follows:

                  (i) If the Stock was traded on The Nasdaq National Market on
the date in question, then the Fair Market Value shall be equal to the
last-transaction price quoted for such date by The Nasdaq National Market;

                  (ii) If the Stock was traded on a stock exchange on the date
in question, then the Fair Market Value shall be equal to the closing price
reported by the applicable composite transactions report for such date; or

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                  (iii) If none of the foregoing provisions is applicable,
then the Fair Market Value shall be determined by the Committee in good faith
on such basis as it deems appropriate. Whenever possible, the determination
of Fair Market Value by the Committee shall be based on the prices reported
in THE WALL STREET JOURNAL or as reported directly to the Corporation by
Nasdaq or a stock exchange. Such determination shall be conclusive and
binding on all persons.

         (k) "IPO" means the initial offering of Stock to the public pursuant to
a registration statement filed by the Corporation with the Securities and
Exchange Commission.

         (l) "OFFERING PERIOD" means a 27-month period with respect to which the
right to purchase Stock may be granted under the Plan, as determined pursuant to
Section 3(a).

         (m) "PARTICIPANT" means an Eligible Employee who elects to participate
in the Plan, as provided in Section 3(c).

         (n) "PARTICIPATING CORPORATION" means (i) the Corporation and (ii) each
present or future Subsidiary designated by the Committee as a Participating
Corporation.

         (o) "PLAN" means this Advanced Medicine, Inc. Employee Stock Purchase
Plan, as it may be amended from time to time.

         (p) "PLAN ACCOUNT" means the account established for each Participant
pursuant to Section 7(a).

         (q) "PURCHASE PRICE" means the price at which Participants may purchase
Stock under the Plan, as determined pursuant to Section 7(b).

         (r) "STOCK" means the Common Stock of the Corporation.

         (s) "SUBSIDIARY" means any corporation (other than the Corporation) in
an unbroken chain of corporations beginning with the Corporation, if each of the
corporations other than the last corporation in the unbroken chain owns stock
possessing 50% or more of the total combined voting power of all classes of
stock in one of the other corporations in such chain.

                                       9<PAGE>

                                  EXHIBIT 10.6

                             ADVANCED MEDICINE, INC.

                        CHANGE IN CONTROL SEVERANCE PLAN

                                       AND

                            SUMMARY PLAN DESCRIPTION

                        Plan Effective Date: [ ] __, 2000

<PAGE>

                             ADVANCED MEDICINE, INC.
                        CHANGE IN CONTROL SEVERANCE PLAN
                                       AND
                            SUMMARY PLAN DESCRIPTION

The Advanced Medicine, Inc. Change in Control Severance Plan (the "Plan") is
primarily designed to provide eligible employees of Advanced Medicine, Inc. (the
"Corporation") whose employment is terminated in connection with a change in
control occurring after an initial public offering with separation pay and other
benefits in the event of involuntary termination.

This Plan is designed to be an "employee welfare benefit plan," as defined in
Section 3(1) of the Employee Retirement Income Security Act of 1974, as amended
("ERISA"). This Plan is governed by ERISA and, to the extent applicable, the
laws of the State of California. This document constitutes both the official
plan document and the required summary plan description under ERISA.

I.       ELIGIBILITY

You will be eligible for severance benefits under the Plan if:

         -        you are an employee of the Corporation;

         -        your active employment is Involuntarily Terminated other than
                  for Misconduct within the designated period following a Change
                  in Control;

         -        you execute the General Release of All Claims, a copy of which
                  is attached, within the prescribed number of days following
                  your date of termination, as set forth in the attached General
                  Release of All Claims; and

         -        you are NOT in one of the excluded categories listed below.

You are NOT eligible for severance benefits under this Plan if:

         -        you are a temporary employee, part-time employee working fewer
                  than 32 hours per week, probationary employee or student
                  employee;

         -        you are employed with a successor employer following a Change
                  in Control. However, you would be eligible for severance
                  benefits pursuant to the terms of the Plan upon a subsequent
                  Involuntary Termination other than for Misconduct within the
                  designated period following a Change in Control; or

         -        you are dismissed for Misconduct.

II.      HOW THE PLAN WORKS

<PAGE>

If you are eligible for severance benefits under the Plan, the amount of your
severance pay will be determined in accordance with the guidelines set forth
below, subject to the Golden Parachute Tax limitation set forth below:

                              SEVERANCE GUIDELINES

IF YOUR EMPLOYMENT IS INVOLUNTARILY TERMINATED WITHIN TWENTY-FOUR (24) MONTHS
AFTER A CHANGE IN CONTROL, YOU WILL BE PAID:

         -        150% of the Eligible Employee's Annual Base Pay plus Target
                  Bonus, if the Eligible Employee was the Chief Executive
                  Officer of the Corporation immediately before the Change in
                  Control; and

         -        100% of the Eligible Employee's Annual Base Pay plus Target
                  Bonus, if the Eligible Employee was an employee (other than
                  the Chief Executive Officer) of the Corporation immediately
                  before the Change in Control.

ANNUAL BASE PAY generally means your base salary at the rate in effect during
the last regularly scheduled payroll period immediately preceding the occurrence
of the Change in Control and does NOT include, for example, bonuses, overtime
compensation, incentive pay, sales commissions or expense allowances.

TARGET BONUS means 100% of the bonus potential established for you by the
Corporation for the applicable fiscal year.

INVOLUNTARY TERMINATION shall have the meaning assigned to such term in the
Corporation's 2000 Equity Incentive Plan.

MISCONDUCT shall have the meaning assigned to such term in the Corporation's
2000 Equity Incentive Plan.

CHANGE IN CONTROL shall have the meaning assigned to such term in the
Corporation's 2000 Equity Incentive Plan.

GOLDEN PARACHUTE TAX LIMITATION

The Internal Revenue Code imposes a 20% excise tax on certain payments and other
benefits received by certain officers and shareholders in connection with a
change of control involving the Corporation. Such payments can include severance
pay and acceleration of option vesting. In the event that the cash severance
payment you would receive under this Plan, when added to any other payments or
benefits received by you, would (i) constitute a "parachute payment" within the
meaning of Section 280G of the Internal Revenue Code ("Code") and (ii) be
subject to the 20% excise tax imposed by Section 4999 of the Code, then your
cash severance payments shall be either

         -        payable in full or

         -        payable as to such lesser amount which would result in no
                  portion of the

2

<PAGE>

                  compensation payable to you being subject to excise tax under
                  Section 4999 of the Code,

whichever of the foregoing amounts, taking into account the applicable Federal,
state and local income taxes and the 20% excise tax imposed by Code Section
4999, results in your receipt, on an after-tax basis, of the greatest amount. If
a reduction is to be effected, your bonus severance payment shall be reduced
first and your salary severance payment next. No payments due you outside of
this Plan shall be reduced by reason of this paragraph. Unless you and the
Corporation agree otherwise in writing, any determination required to make this
adjustment shall be made in writing by the Corporation's independent public
accountants or other outside auditors selected by the Corporation immediately
prior to the change of control triggering the parachute payments, whose
determination shall be binding upon you and the Corporation. You and the
Corporation are obligated to furnish to the accountants such information and
documents as the accountants may reasonably request. The Corporation shall bear
all costs of engaging the accountants in connection with these calculations.

III.     OTHER IMPORTANT INFORMATION

PLAN ADMINISTRATION. As the Plan Administrator, the Corporation has full
discretionary authority to administer and interpret the Plan, including
discretionary authority to determine eligibility for benefits under the Plan and
the amount of benefits (if any) payable per participant. Any determination by
the Plan Administrator will be final and conclusive upon all persons. The Plan
Administrator hereby delegates to the Chief Financial Officer all of its
administrative duties. Accordingly, the Chief Financial Officer, on behalf of
the Plan Administrator, has full discretionary authority to carry out its
delegated duties. Any determination by the Chief Financial Officer will be final
and conclusive upon all persons. The Corporation, as the Plan Administrator,
will indemnify and hold harmless the Chief Financial Officer for carrying out
the responsibilities of the Plan Administrator; provided, however, such person
does not act with gross negligence or willful misconduct.

BENEFITS. When benefits are due, they will be paid from the general assets of
the Corporation. The Corporation is not required to establish a trust to fund
the Plan. The benefits provided under this Plan are not assignable and may be
conditioned upon your compliance with any confidentiality agreement you have
entered into with the Corporation or upon your compliance with any Corporation
policy or program.

CLAIMS PROCEDURE. If you believe you are incorrectly denied a benefit or are
entitled to a greater benefit than the benefit you receive under the Plan, you
may submit a signed, written application to the Plan Administrator within ninety
(90) days of your Termination Date. You will be notified of the approval or
denial of this claim within ninety (90) days of the date that the Plan
Administrator receives the claim, unless special circumstances require an
extension of time for processing the claim. If your claim is denied, the
notification will state specific reasons for the denial and you will have sixty
(60) days from receipt of the written notification of the denial of your claim
to file a signed, written request for a review of the denial with the Plan
Administrator. This request should include the reasons you are requesting a
review, facts supporting your

3

<PAGE>

request and any other relevant comments. Pursuant to its discretionary
authority to administer and interpret the Plan and to determine eligibility
for benefits under the Plan, the Plan Administrator will generally make a
final, written determination of your eligibility for benefits within sixty
(60) days of receipt of your request for review.

PLAN TERMS. This Plan supersedes any and all prior separation, severance and
salary continuation arrangements, programs and plans which were previously
offered by the Corporation, for which you are eligible, but excluding terms of
the Corporation's stock option plans and individual letter agreements which
address the vesting of stock options or restricted stock.

PLAN AMENDMENT OR TERMINATION. The Corporation, acting through its Board of
Directors or its Compensation Committee, reserves the right to terminate or
amend the Plan at any time and in any manner. Any termination or amendment of
the Plan may be made effective immediately with respect to any benefits not yet
paid, whether or not prior notice of such amendment or termination has been
given to affected employees. However, no amendment or termination may be
approved following any Change in Control involving the Corporation.

TAXES.  The Corporation will withhold taxes and other payroll deductions from
any severance payment.

NO RIGHT TO EMPLOYMENT. This Plan does not provide you with any right to
continue employment with the Corporation or affect the Corporation's right,
which right is hereby expressly reserved, to terminate the employment of any
individual at any time for any reason with or without cause.

IV.  STATEMENT OF ERISA RIGHTS

As a participant in the Plan, you are entitled to certain rights and protections
under the Employee Retirement Income Security Act of 1974, as amended ("ERISA").
ERISA provides that all Plan participants shall be entitled to:

         1.       Examine, without charge, at the Plan Administrator's office,
                  all Plan documents, including all documents filed by the Plan
                  with the U.S. Department of Labor.

         2.       Obtain copies of all Plan documents and other Plan information
                  upon written request to the Plan Administrator. The Plan
                  Administrator may make a reasonable charge for the copies.

         3.       File suit in a federal court, if you, as a participant,
                  request materials and do not receive them within thirty (30)
                  days of your request. In such a case, the court may require
                  the Plan Administrator to provide the materials and to pay you
                  a fine of up to $100 for each day's delay until the materials
                  are received, unless the materials were not sent because of
                  reasons beyond the control of the Plan Administrator.

In addition to creating rights for certain employees of the Corporation under
the Plan, ERISA imposes obligations upon the people who are responsible for the
operation of the Plan. The people

4

<PAGE>

who operate the Plan (called "fiduciaries") have a duty to do so prudently
and in the interest of the Corporation's employees who are covered by the
Plan.

No one, including your employer or any other person, may fire you or otherwise
discriminate against you in any way to prevent you from obtaining a benefit to
which you are entitled under the Plan or from exercising your rights under
ERISA.

If your claim for a severance benefit is denied or ignored, in whole or in part,
you have a right to file suit in a federal or a state court. If Plan fiduciaries
are misusing the Plan's assets (if any) or if you are discriminated against for
asserting your rights, you may seek assistance from the U.S. Department of Labor
or file suit in a federal court. The court will decide who will pay court costs
and legal fees. If you are successful in your lawsuit, the court may, if it so
decides, order the party you have sued to pay your legal costs, including
attorney fees. However, if you lose, the court may order you to pay these costs
and fees, for example, if it finds that your claim or suit is frivolous.

If you have any questions about the Plan, this statement or your rights under
ERISA, you should contact the Plan Administrator or the nearest Area Office of
the U.S. Labor-Management Services Administration, Department of Labor.

5

<PAGE>

                           ADDITIONAL PLAN INFORMATION
<TABLE>

================================================================================
<S>                               <C>
Name of Plan:                     Advanced Medicine, Inc. Change in Control
                                  Severance Plan
--------------------------------------------------------------------------------
Corporation Sponsoring Plan:      Advanced Medicine, Inc.
                                  901 Gateway Boulevard
                                  South San Francisco, CA  94080
                                  650-808-6000
--------------------------------------------------------------------------------
Employer Identification Number:   94-3265960
--------------------------------------------------------------------------------
Plan Number:                      50_

--------------------------------------------------------------------------------
Plan Year:                        The calendar year; the first plan year shall
                                  end December 31, 2000
--------------------------------------------------------------------------------
Plan Administrator:               Advanced Medicine, Inc.
                                  901 Gateway Boulevard
                                  South San Francisco, CA  94080
                                  650-808-6000
--------------------------------------------------------------------------------
Agent for Service of Legal        Plan Administrator
Process:
--------------------------------------------------------------------------------
Type of Plan:                     Severance Plan/Employee Welfare Benefit Plan
--------------------------------------------------------------------------------
Plan Costs:                       The cost of the Plan is paid by Advanced
                                  Medicine, Inc.
================================================================================
</TABLE>

6

<PAGE>

                          GENERAL RELEASE OF ALL CLAIMS

         In consideration of the severance benefit to be paid to me by Advanced
Medicine, Inc. under the Advanced Medicine, Inc. Severance Plan, I hereby fully
and forever release and discharge Advanced Medicine, Inc. and its directors,
officers, employees, agents, successors, predecessors, subsidiaries,
shareholders, employee benefit plans and assigns (together called "the
Corporation"), from all claims and causes of action arising out of or relating
in any way to my employment with the Corporation, including the termination of
my employment.

         1. I understand and agree that this RELEASE is a full and complete
waiver of all claims, including (without limitation) claims of wrongful
discharge, breach of contract, breach of the covenant of good faith and fair
dealing, violation of public policy, defamation, personal injury or emotional
distress and claims under Title VII of the Civil Rights Act of 1964, as amended,
the Fair Labor Standards Act, the Equal Pay Act of 1963, the Americans With
Disabilities Act, the Civil Rights Act of 1866, the California Fair Employment
and Housing Act or any other federal or state law or regulation relating to
employment or employment discrimination. I further understand and agree that
this RELEASE is a full and complete waiver of all claims, including (without
limitation) claims under the Employee Retirement Income Security Act of 1974, as
amended (ERISA), related to severance benefits. I further understand that by
this RELEASE I agree not to assist, encourage, institute or cause to be
instituted the filing of any administrative charge or legal proceeding against
the Corporation relating to employment discrimination.

         2. I also hereby agree that nothing contained in this RELEASE shall
constitute or be treated as an admission of liability or wrongdoing by the
Corporation or me.

         3. I agree to abide by the Corporation's Proprietary Information and
Inventions Agreement that I previously executed.

         4. In addition, I hereby expressly waive any and all rights and
benefits conferred upon me by the provisions of Section 1542 of the Civil Code
of the State of California or any analogous provision under any other state law,
which states as follows:

         A general release does not extend to claims which the creditor does not
know or suspect to exist in his favor at the time of executing the release,
which if known by him must have materially affected his settlement with the
debtor.

         5. I understand that I have until the close of business on __________,
____, to review and consider this RELEASE, discuss it with an attorney of my own
choosing, and decide to execute it or not execute it. I hereby acknowledge that
I have read and understand the foregoing RELEASE and that I sign it voluntarily
and without coercion. I further acknowledge that I was given an opportunity to
consider and review this RELEASE and to consult with an attorney of my own
choosing concerning the waivers contained in this RELEASE and that the waivers
are knowing, conscious and with full appreciation that I am forever foreclosed
from pursuing any of the rights that I waived.

____________,_____        __________________________________________________
                                    Signature

_____________________________________________
Print Full Name

<PAGE>
                    --------------------------------------------
                       YOU ARE ADVISED TO CONSULT AN ATTORNEY
                             BEFORE SIGNING THIS RELEASE.
                    --------------------------------------------

                          GENERAL RELEASE OF ALL CLAIMS

         In consideration of the severance benefit to be paid to me by Advanced
Medicine, Inc. under the Advanced Medicine, Inc. Severance Plan, I hereby fully
and forever release and discharge Advanced Medicine, Inc. and its directors,
officers, employees, agents, successors, predecessors, subsidiaries,
shareholders, employee benefit plans and assigns (together called "the
Corporation"), from all claims and causes of action arising out of or relating
in any way to my employment with the Corporation, including the termination of
my employment.

1. I understand and agree that this RELEASE is a full and complete waiver of all
claims, including (without limitation) claims of wrongful discharge, breach of
contract, breach of the covenant of good faith and fair dealing, violation of
public policy, defamation, personal injury or emotional distress and claims
under Title VII of the Civil Rights Act of 1964, as amended, the Fair Labor
Standards Act, the Equal Pay Act of 1963, the Americans With Disabilities Act,
the Civil Rights Act of 1866, the Age Discrimination in Employment Act of 1967,
as amended (ADEA), the California Fair Employment and Housing Act or any other
federal or state law or regulation relating to employment or employment
discrimination. I further understand and agree that this RELEASE is a full and
complete waiver of all claims, including (without limitation) claims under the
Employee Retirement Income Security Act of 1974, as amended (ERISA), related to
severance benefits. I further understand that by this RELEASE I agree not to
assist, encourage, institute or cause to be instituted the filing of any
administrative charge or legal proceeding against the Corporation relating to
employment discrimination.

                  2. I also hereby agree that nothing contained in this RELEASE
shall constitute or be treated as an admission of liability or wrongdoing by me
or by the Corporation.

                  3. I agree to abide by the Corporation's Proprietary
Information and Inventions Agreement that I previously executed.

                  4. In addition, I hereby expressly waive any and all rights
and benefits conferred upon me by the provisions of Section 1542 of the Civil
Code of the State of California, or any analogous provision under any other
state law, which states as follows:

A general release does not extend to claims which the creditor does not know or
suspect to exist in his favor at the time of executing the release, which if
known by him must have materially affected his settlement with the debtor.

                  5. I hereby acknowledge that I have read and understand the
foregoing RELEASE and that I sign it voluntarily and without coercion. I further
acknowledge that I was given an opportunity to consider and review this RELEASE
and to consult with an attorney of my own choosing concerning the waivers
contained in this RELEASE and that the waivers are knowing, conscious and with
full appreciation that I am forever foreclosed from pursuing any of the rights
that I waived.

                  6. I understand that I have the right to consult with an
attorney before signing this Release. I also understand that, as provided under
the Older Workers Benefit Protection Act of 1990, I have 45 days after receipt
of this RELEASE to review and consider this RELEASE, discuss it with an attorney
of my own choosing, and decide to execute it or not execute it. I also
understand that I may

<PAGE>

revoke this RELEASE during a period of seven days after I sign it and that
this RELEASE will not become effective for seven days after I sign it (and
then only if I do not revoke it). In order to revoke this RELEASE, I must
deliver to the __________ of Advanced Medicine, Inc., within seven days after
I executed this RELEASE, a letter stating that I am revoking it.

         7. I acknowledge that I have been provided with a notice, as required
by the Older Workers Benefit Protection Act of 1990, that contains information
about the individuals covered under the Advanced Medicine, Inc. Change in
Control Severance Plan, the eligibility factors for participation in the Plan,
the time limits applicable to the Plan, the job titles and ages of the employees
designated to participate in the Plan, and the job titles and ages of the
employees who have not been designated to participate in the Plan. (See
ATTACHMENT 1.)

         8. I understand that if I choose to revoke this RELEASE within seven
days after I signed it, I will not receive any severance benefit and the RELEASE
will have no effect.

         9. Before signing my name to this RELEASE, I state that:

I have read it,

I understand it,

I know that I am giving up important rights,

I am aware of my right to consult an attorney before signing it, and

I have signed it knowingly and voluntarily.

____________,_____        __________________________________________________
                                             Signature

_____________________________________________
              Print Full Name

<PAGE>

                                  ATTACHMENT 1

                                  NOTICE ABOUT

          THE ADVANCED MEDICINE, INC. CHANGE IN CONTROL SEVERANCE PLAN

         As required by the Older Workers Benefit Protection Act of 1990, this
notice contains information about the individuals covered under the Advanced
Medicine, Inc. Change in Control Severance Plan (the "Plan"), the eligibility
factors for participation in the Plan, the time limits applicable to the Plan,
the job titles and ages of the employees designated to participate in the Plan,
and the job titles and ages of the employees who have not been designated to
participate in the Plan.

         1. The Plan applies to regular employees of the Corporation whose
employment is terminated following a Change in Control on or after ________ __,
2000, and on or before ________ __, 2000 (provided that they meet the other
requirements of the Plan).

         Employees are not eligible to receive a benefit under the Plan unless
they sign a General Release of All Claims (the "Release"). Employees who have
attained age 40 must return the Release to the Corporation within 45 days after
receiving the form. Once the signed Release is returned to the Corporation, the
employees have seven days to revoke the Release.

         The following is a listing of the ages and job titles of employees of
the Corporation who were and were not selected for termination and participation
in the Plan:

<TABLE>
<CAPTION>
---------------------------------------------------------------------------------------------------------------------

                    JOB TITLE                         AGE          NUMBER SELECTED          NUMBER NOT SELECTED
<S>                                                <C>             <C>                      <C>
---------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------

---------------------------------------------------------------------------------------------------------------------

</TABLE>

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