Document:

EX-10.30

 Exhibit 10.30 
 THIRD AMENDMENT TO 
 LOAN AND SECURITY AGREEMENT 

THIS THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT (this “Agreement”) is dated as of May 3, 2012, by and
among REGADO BIOSCIENCES, INC., a Delaware corporation (“Borrower”), MIDCAP FINANCIAL SBIC, LP, a Delaware limited partnership in its capacity as agent (“Agent”) for the lenders under the Loan
Agreement (as defined below) (“Lenders”), and the Lenders. 
 W I T N E S S E T H: 

WHEREAS, Borrower, Lenders and Agent are parties to that certain Loan and Security Agreement, dated as of May 25, 2011, and
as amended by that certain First Amendment to Loan and Security Agreement, dated as of August 1, 2011 and that certain Second Amendment to Loan and Security Agreement, dated as of September 30, 2011 (as so amended and as may be further
amended, restated, supplemented or otherwise modified from time to time, the “Loan Agreement”; capitalized terms used herein have the meanings given to them in the Loan Agreement except as otherwise expressly defined herein),
pursuant to which Lenders have agreed to provide to Borrower certain loans and other extensions of credit in accordance with the terms and conditions thereof; 
 WHEREAS, Borrower has requested that Agent and Lenders agree to amend certain terms of the Loan Agreement in order to permit Borrower to enter into a Convertible Note Purchase Agreement, dated as of the
date of this Amendment, by and among Borrower and certain purchasers (the “Purchasers”), in the form attached hereto as Exhibit A (the “Subordinated Note Purchase Agreement”), pursuant to which the Borrower
will issue to Purchasers unsecured convertible promissory notes in the form attached as Exhibit B to the Subordinated Note Purchase Agreement, which Indebtedness shall constitute Subordinated Debt, in an aggregate amount not to exceed $13,561,080;
and 
 WHEREAS, Agent and Lenders are willing, and Borrower desires, to amend certain provisions of the Loan Agreement in
order to provide for such Subordinated Debt, all in accordance with, and subject to, the terms and conditions set forth herein. 

NOW, THEREFORE, in consideration of the premises, the covenants and agreements contained herein, and other good and valuable
consideration, the receipt and adequacy of which are hereby acknowledged, Borrower, Lenders and Agent hereby agree as follows: 

1. Acknowledgment of Obligations. Borrower hereby acknowledges, confirms and agrees that all Term Loans made prior to the
date hereof, together with interest accrued and accruing thereon, and fees, costs, expenses and other charges owing by Borrower to Agent and Lenders under the Loan Agreement and the other Debt Documents, are unconditionally owing by Borrower to
Agent and Lenders, without offset, defense or counterclaim of any kind, nature or description whatsoever except as may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or other similar laws relating to or affecting
creditor’s rights generally. 

 2. Amendments to Loan Agreement. Subject to the terms and conditions of this
Agreement, including, without limitation, the conditions to effectiveness set forth in Section 5 below, the Agent and Lenders hereby agree that the Loan Agreement shall be amended as follows: 

(a) Section 7.2 of the Loan Agreement is hereby amended by deleting clause (c) of such section in its entirety and
substituting in lieu thereof the following new clause (c) to read in its entirety as follows: “(c)(i) have a change in senior management, or (ii) enter into any transaction or series of related transactions which would result in a
Change in Control;” 
 (b) Section 8.9 of the Loan Agreement is hereby amended by deleting such section in its
entirety and substituting in lieu thereof the following new Section 8.9 to read in its entirety as follows: 

“8.9 Subordinated Debt. A default or breach occurs under the Subordinated Convertible Debt Documents or any other agreement
between Borrower and any creditor of Borrower that signed a subordination, intercreditor, or other similar agreement with Agent or the Lenders, or any creditor that has signed such an agreement with the Agent or the Lenders breaches any terms of
such agreement;” 
 (c) The Loan Agreement is hereby further amended by (i) deleting the word “or” at the
end of Section 8.12, (ii) replacing the period at the end of Section 8.13 with the word “; or”, and (iii) inserting the following new Section 8.14 to read in its entirety as follows:

 “8.14 Change in Control. A Change in Control shall have occurred.” 

(d) Section 12.8 of the Loan Agreement is hereby amended by deleting such section in its entirety and substituting in lieu
thereof the following new Section 12.8 to read in its entirety as follows: 
 “12.8 Survival;
Termination. All covenants, representations and warranties made in this Agreement continue in full force until this Agreement has terminated pursuant to its terms and all Obligations (other than inchoate indemnity obligations for which a claim
has not yet been made in writing and any other obligations which, by their terms, are to survive the termination of this Agreement) have been satisfied. This Agreement shall terminate upon the occurrence of all of the following conditions:
(i) confirmation in writing by Agent of payment in full in cash of all of the Obligations (other than inchoate indemnity obligations for which a claim has not yet been made in writing and any other obligations which, by their terms, are to
survive the termination of this Agreement), (ii) to the extent requested by Agent, receipt by Agent and Lenders of liability releases from the Borrower in form and substance reasonably acceptable to the Agent, and (iii) the Term Loan
Commitments shall have expired and Agent and Lenders shall have no obligation to extend any further Term Loans or other credit to Borrower; provided, however, the provisions of Sections 2.5, 2.6, 11, 12.2,
12.9 and 13.7, and the other indemnities contained in the Loan Documents shall survive the termination of this Agreement.” 

  
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 (e) Section 14 of the Loan Agreement is hereby amended by deleting the
definition of “Change in Control” in its entirety and substituting in lieu thereof the following new definition to read in its entirety as follows: 
 “‘Change in Control’ means any event, transaction, or occurrence, or series of events, transactions or occurrences, as a result of which (i) the stockholders of Borrower who
were not stockholders immediately prior to such transaction own more than forty percent (40%) of the voting stock of Borrower immediately after giving effect to such transaction or related series of such transactions (other than by the sale of
Borrower’s equity securities in a public offering or to venture capital investors so long as Borrower identifies to Agent the venture capital investors prior to the closing of the transaction) or (ii) a “Change of Control” will
have occurred under and as defined in any Subordinated Convertible Debt Document.” 
 (f) Section 14 of the
Loan Agreement is hereby further amended by (i) deleting the word “and” at the end of clause (g) of the definition of “Permitted Indebtedness”, (ii) replacing the period at the end of clause (h) of the
definition of “Permitted Indebtedness” with the word “; and”, and (iii) inserting the following new clause (i) to the definition of “Permitted Indebtedness”: 

“(i) Subordinated Debt incurred by Borrower pursuant to the Subordinated Convertible Debt Documents, in an amount not to exceed
$13,561,080 plus any paid-in-kind interest accrued thereunder in accordance with the terms of the Subordinated Convertible Debt Documents in effect on the Third Amendment Effective Date, so long as each Subordinated Note Purchaser has executed and
delivered the Subordinated Convertible Debt Subordination Agreement (or a joinder thereto in form and substance reasonably satisfactory to Agent).” 
 (g) Section 14 of the Loan Agreement is hereby further amended by deleting the definition of “Subordinated Debt” in its entirety and substituting in lieu thereof the following new
definition to read in its entirety as follows: 
 “‘Subordinated Debt’ means indebtedness incurred by
Borrower subordinated to all of Borrower’s now or hereafter indebtedness to the Lenders (pursuant to a subordination, intercreditor, or other similar agreement in form and substance satisfactory to Agent and the Lenders entered into between
Agent, Borrower and the other creditor), on terms acceptable to Agent and the Lenders, including, without limitation, the Subordinated Debt incurred by Borrower pursuant to the Subordinated Convertible Debt Documents.” 

(h) Section 14 of the Loan Agreement is hereby further amended by inserting the following new definitions in proper
alphabetical order: 

  
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 “‘Subordinated Convertible Debt Documents’ means collectively, the
Subordinated Note Purchase Agreement, the Subordinated NPA Notes and each other agreement, instrument or other document executed in connection therewith.” 
 “‘Subordinated Convertible Debt Subordination Agreement’ means that certain Subordination Agreement, dated as of May 3, 2012, by and among Borrower, Agent and each of the
Subordinated Note Purchasers.” 
 “‘Subordinated Note Purchase Agreement’ means that certain
Convertible Note Purchase Agreement, dated as of May 3, 2012, by and among Borrower and the Subordinated Note Purchasers, in the form attached as Exhibit A to the Third Amendment.” 

“‘Subordinated Note Purchasers’ means each of the ‘Purchasers’ under and as defined in the Subordinated
Note Purchase Agreement and any other holder of any Subordinated NPA Notes.” 
 “‘Subordinated NPA
Notes’ means each of the ‘Notes’ issued pursuant to and as defined in the Subordinated Note Purchase Agreement in the form attached to the Subordinated Note Purchase Agreement as Exhibit A.” 

“‘Third Amendment’ means that certain Third Amendment to Loan and Security Agreement, dated as of the Third
Amendment Effective Date.” 
 “‘Third Amendment Effective Date’ means May 3, 2012.”

 3. No Other Amendments. Except for the amendments and agreements set forth and referred to in
Section 2 above, the Loan Agreement and the other Debt Documents shall remain unchanged and in full force and effect. Nothing in this Agreement is intended, or shall be construed, to constitute a novation or an accord and satisfaction of
any of Borrower’s Obligations or to modify, affect or impair the perfection or continuity of Agent’s security interests in, security titles to or other liens, for the benefit of itself and the Lenders, on any Collateral for the
Obligations. 
 4. Representations and Warranties. To induce Agent and Lenders to enter into this Agreement,
Borrower does hereby warrant, represent and covenant to Agent and Lenders that (i) each representation or warranty of Borrower set forth in the Loan Agreement is hereby restated and reaffirmed as true and correct in all material respects on and
as of the date hereof as if such representation or warranty were made on and as of the date hereof (except to the extent that any such representation or warranty expressly relates to a prior specific date or period), (ii) no Default or Event of
Default has occurred and is continuing as of the date hereof and (iii) Borrower has the power and is duly authorized to enter into, deliver and perform this Agreement and this Agreement is the legal, valid and binding obligation of Borrower
enforceable against Borrower in accordance with its terms. 

  
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 5. Condition Precedent to Effectiveness of this Agreement. This Agreement
shall become effective as of the date (the “Amendment Effective Date”) upon which each of the following conditions precedent is satisfied as determined in Agent’s sole discretion: 

(a) Agent has received one or more counterparts of this Agreement duly executed and delivered by Borrower, Agent and Lenders, in form and
substance satisfactory to Agent and Lenders; and 
 (b) Agent has received a duly executed and delivered Officer’s
Certificate, in form and substance satisfactory to Agent. 
 6. Release. 

(a) In consideration of the agreements of Agent and Lenders contained herein and for other good and valuable consideration, the receipt
and sufficiency of which is hereby acknowledged, Borrower, on behalf of itself and its successors, assigns, and other legal representatives, hereby absolutely, unconditionally and irrevocably releases, remises and forever discharges Agent and each
Lender and their respective successors and assigns, and their respective present and former shareholders, affiliates, subsidiaries, divisions, predecessors, directors, officers, attorneys, employees, agents and other representatives (Agent, Lenders
and all such other persons being hereinafter referred to collectively as the “Releasees” and individually as a “Releasee”), of and from all demands, actions, causes of action, suits, covenants, contracts,
controversies, agreements, promises, sums of money, accounts, bills, reckonings, damages and any and all other claims, counterclaims, defenses, rights of set-off, demands and liabilities whatsoever (individually, a “Claim” and
collectively, “Claims”) of every name and nature, known or unknown, suspected or unsuspected, both at law and in equity, which Borrower or any of its successors, assigns, or other legal representatives may now or hereafter own,
hold, have or claim to have against the Releasees or any of them for, upon, or by reason of any circumstance, action, cause or thing whatsoever which arises at any time on or prior to the Amendment Effective Date, including, without limitation, for
or on account of, or in relation to, or in any way in connection with the Loan Agreement or any of the other Debt Documents or transactions thereunder or related thereto. 
 (b) Borrower understands, acknowledges and agrees that its release set forth above may be pleaded as a full and complete defense and may be used as a basis for an injunction against any action, suit or
other proceeding which may be instituted, prosecuted or attempted in breach of the provisions of such release. 
 (c) Borrower
agrees that no fact, event, circumstance, evidence or transaction which could now be asserted or which may hereafter be discovered shall affect in any manner the final, absolute and unconditional nature of the release set forth above. 

7. Covenant Not To Sue. Borrower, on behalf of itself and its successors, assigns, and other legal representatives, hereby
absolutely, unconditionally and irrevocably, covenants and agrees with and in favor of each Releasee that it will not sue (at law, in equity, in any regulatory proceeding or otherwise) any Releasee on the basis of any Claim released,

  
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remised and discharged by Borrower pursuant to Section 6 above. If Borrower or any of its successors, assigns or other legal representatives violates the foregoing covenant, Borrower,
for itself and its successors, assigns and legal representatives, agrees to pay, in addition to such other damages as any Releasee may sustain as a result of such violation, all attorneys’ fees and costs incurred by any Releasee as a result of
such violation. 
 8. Advice of Counsel. Each of the parties represents to each other party hereto that it has
discussed this Agreement with its counsel. 
 9. Severability of Provisions. In case any provision of or
obligation under this Agreement shall be invalid, illegal or unenforceable in any applicable jurisdiction, the validity, legality and enforceability of the remaining provisions or obligations, or of such provision or obligation in any other
jurisdiction, shall not in any way be affected or impaired thereby. 
 10. Counterparts. This Agreement may be
executed in multiple counterparts, each of which shall be deemed to be an original and all of which when taken together shall constitute one and the same instrument. 
 11. GOVERNING LAW. THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF MARYLAND APPLICABLE TO CONTRACTS MADE AND PERFORMED IN SUCH STATE
WITHOUT REGARD TO THE PRINCIPLES THEREOF REGARDING CONFLICTS OF LAWS. 
 12. Entire Agreement. The Loan Agreement
as and when amended through this Agreement embodies the entire agreement between the parties hereto relating to the subject matter thereof and supersedes all prior agreements, representations and understandings, if any, relating to the subject
matter thereof. 
 13. No Strict Construction, Etc. The parties hereto have participated jointly in the
negotiation and drafting of this Agreement. In the event an ambiguity or question of intent or interpretation arises, this Agreement shall be construed as if drafted jointly by the parties hereto and no presumption or burden of proof shall arise
favoring or disfavoring any party by virtue of the authorship of any provisions of this Agreement. Time is of the essence for this Agreement. 
 14. Costs and Expenses. Borrower absolutely and unconditionally agrees to pay or reimburse upon demand for all reasonable fees, costs and expenses incurred by Agent and the Lenders that are
Lenders on the Closing Date in connection with the preparation, negotiation, execution and delivery of this Agreement and any other Debt Documents or other agreements prepared, negotiated, executed or delivered in connection with this Agreement or
transactions contemplated hereby. 
 [Remainder of page intentionally blank; signature pages follow.] 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Third Amendment to Loan and
Security Agreement to be duly executed and delivered as of the day and year specified at the beginning hereof. 
  

			
	 BORROWER:
  

REGADO BIOSCIENCES, INC.

		
	By:	 	/s/ David J. Mazzo
	Name:	 	David Mazzo, Ph.D.
	Title:	 	Chief Executive Officer

 REGADO BIOSCIENCES, INC. 
 THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT 
 SIGNATURE PAGE 

 
			
	 AGENT AND LENDER:
  

MIDCAP FINANCIAL SBIC, LP, as Agent and Lender
  

By: MIDCAP FINANCIAL SBIC GP, LLC

		
	By:	 	/s/ Luis Viera
	Name:	 	Luis Viera
	Title:	 	Authorized Signatory

 REGADO BIOSCIENCES, INC. 
 THIRD AMENDMENT TO LOAN AND SECURITY AGREEMENT 
 SIGNATURE PAGEEX-10.31

 Exhibit 10.31 
 CONVERTIBLE NOTE PURCHASE AGREEMENT 
 This Convertible Note Purchase
Agreement, dated as of May 3, 2012 (the “Agreement”), is entered into by and among Regado Biosciences, Inc., a Delaware corporation (the “Company”), and the purchasers listed on the Schedule of Purchasers
attached to this Agreement as Exhibit A (each a “Purchaser”). 
 In consideration of the mutual
promises and covenants contained in this Agreement, the parties hereto agree as follows: 
 1. Sale of Notes. 

(a) Subject to the terms and conditions of this Agreement, at the Closing (as defined below), the Company will issue and sell to each
Purchaser, and each Purchaser will purchase from the Company, an unsecured convertible promissory note in the form attached hereto as Exhibit B (each a “Note” and collectively, the “Notes” which term shall
also include any Notes delivered in exchange or replacement thereof) in the principal amount set forth beside such Purchaser’s name on Exhibit A in the Closing column. The Company has authorized the issuance and sale of Notes up to the
aggregate principal amount of $13,561,080. The initial closing of the purchase and sale of the Notes being purchased by the Purchasers hereunder (the “Initial Closing”) will take place remotely at 10:00 AM on May 3, 2012, or at
such other date, time and place as the Company and the Purchasers mutually agree via exchange of documents and signatures (the “Initial Closing Date”). At the Initial Closing, each Purchaser severally will deliver to the Company
payment in full for the Note in the amount set forth beside such Purchaser’s name on Exhibit A in the Initial Closing column. Each Note shall automatically be converted into shares of Equity Securities (as defined below) as provided in
such Note upon the closing of the Company’s sale of Equity Securities to investors in a financing transaction with aggregate proceeds to the Company of not less than $20,000,000, excluding the conversion of the Notes (a “Qualified
Equity Financing”). Additional conversion provisions are set forth in the Notes. 
 For purposes of this Agreement, the
term “Equity Securities” shall mean shares of the Company’s preferred stock sold after the date hereof. The Notes and Equity Securities shall hereinafter referred to as the “Securities.” In the event there is
more than one closing, the term “Closing” shall apply to each such closing unless otherwise specified. 
 (b)
After the Initial Closing, the Company may sell, issue and deliver additional Notes on the same terms and conditions as set forth in Section 1(a) above, to other investors (the “Additional Purchasers”) (each an
“Additional Closing”). At such Additional Closing(s), if any, Exhibit A to this Agreement will be updated to include the name of each Additional Purchaser purchasing Notes at any Additional Closing and the amount of Notes
such Additional Purchaser is purchasing and become a part of this Agreement. Any Additional Purchaser will become a party to this Agreement by executing a counterpart signature page to this Agreement and will, as of the date of an Additional
Closing, be treated for all purposes as a Purchaser under the terms of this Agreement and the Notes acquired by such Additional Purchaser will be deemed to be sold under this Agreement. The Additional Closing(s), if any, must occur within ninety
(90) days of the Initial Closing. No Purchaser has any preemptive rights, rights of first refusal or other similar rights with respect to any Notes issued or sold pursuant to any Additional Closing. 

(c) At the Initial Closing and each Additional Closing, each Purchaser will deliver to the Company payment in full for the Note in the
amount equal to the principal amount set forth opposite such Purchaser’s name on Exhibit A, which such Purchaser severally agrees to purchase at the Initial Closing 

 
or the Additional Closing, as the case may be, by (i) a check payable to the Company’s order, (ii) wire transfer of funds to the Company, or (iii) any combination of the
foregoing. At the Initial Closing or the Additional Closing, as the case may be, the Company will deliver to each Purchaser a duly executed Note in the principal amount set forth opposite such Purchaser’s name on Exhibit A.

 2. Representations of the Company. The Company hereby represents and warrants to each Purchaser as follows, which
representations and warranties are made as of the Initial Closing: 
 2.1 Organization and Standing. The
Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware and has full corporate power and authority to conduct its business as presently conducted and as proposed to be conducted by it
and to enter into and perform this Agreement and to carry out the transactions contemplated by this Agreement. 

2.2 Issuance of Notes and Shares. To the extent that the Notes are convertible into Equity Securities, the Company
shall, prior to the conversion of the Notes and for issuance and delivery upon the conversion of the Notes, reserve from its authorized but unissued shares of its capital stock, such number of shares of Equity Securities (and shares of its Common
Stock for issuance upon conversion of such Equity Securities), and, from time to time, will take all steps necessary to amend its Certificate of Incorporation to provide sufficient authorized numbers of shares of Equity Securities issuable upon
conversion of the Notes (and shares of its Common Stock for issuance upon conversion of such Equity Securities). 

2.3 Authority for Agreement. The execution, delivery and performance by the Company of this Agreement and the
Notes, and the consummation by the Company of the transactions contemplated hereby and thereby, have been duly authorized by all necessary corporate action. Each of this Agreement and the Notes have been duly executed and delivered by the Company
and constitutes a valid and binding obligation of the Company enforceable in accordance with its terms. The execution and performance of the transactions contemplated by this Agreement and the Notes, and compliance with their provisions by the
Company will not violate any provision of law and will not conflict with or result in any breach of any of the terms, conditions or provisions of, or constitute a default under, or require a consent or waiver under, its Certificate of Incorporation
or By-Laws (each as amended to date) or any indenture, lease, agreement or other instrument to which the Company is a party or by which it or any of its properties is bound, or any decree, judgment, order, statute, rule or regulation applicable to
the Company. The issuance of the Notes is not, and the subsequent conversion/exercise of the Notes into Note Shares will not be, subject to any preemptive rights or rights of first refusal that have not been properly waived or complied with.

 3. Representations of the Purchasers. Each Purchaser severally, but not jointly, represents and warrants to the
Company as follows solely with respect to such Purchaser, which representations and warranties are made as of the date of the Closing at which such Purchaser is purchasing the Notes: 

3.1 Investment. The Purchaser is acquiring the Note and the Note Shares for its own account for investment and not
with a view to, or for sale in connection with, any distribution thereof, nor with any present intention of distributing or selling the same; and, except as contemplated by this Agreement and the Exhibits hereto, the Purchaser has no present or
contemplated agreement, undertaking, arrangement, obligation, indebtedness or commitment providing for the disposition thereof. 

  
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 3.2 Experience. The Purchaser has carefully reviewed the
representations concerning the Company contained in this Agreement, has made detailed inquiry concerning the Company, its business and its personnel; the officers of the Company have made available to the Purchaser any and all written information
which he or it has requested and have answered to the Purchaser’s satisfaction all inquiries made by the Purchaser; and the Purchaser has sufficient knowledge and experience in investing in companies similar to the Company so as to be able to
evaluate the risks and merits of his or its investment in the Company and is able financially to bear the risks thereof. 
 3.3 Accredited Investor. The Purchaser is an “Accredited Investor” within the definition set forth in Rule 501(a) issued pursuant to the Securities Act of 1933, as amended (the
“Securities Act”). 
 3.4 No Public Market. The Purchaser understands that no public
market now exists for any of the securities issued by the Company, and that the Company has made no assurances that a public market will ever exist for the Securities. 

3.5 Exemption; Restricted Securities. The Purchaser understands that the Securities have not been registered under
the Securities Act or any state securities laws, on the grounds that the sale provided for in this Agreement and the issuance of securities hereunder is exempt from registration under the Securities Act and under applicable state securities laws and
that the Company’s reliance on such exemptions is predicated in part upon the Purchaser’s representations and warranties set forth herein. The Purchaser understands that in the absence of an effective registration statement covering the
Securities, or an exemption therefrom under the Securities Act and all applicable state securities laws, such securities must be held indefinitely. 
 3.6 Authority for Agreement. The Purchaser has full power and authority to enter into and to perform this Agreement in accordance with its terms and all necessary corporate action have hereby been
duly authorized by all necessary corporate action. This Agreement has been duly executed and delivered by the Purchaser and constitutes a valid and binding obligation of the Purchaser enforceable in accordance with its terms. The execution of and
performance of the transactions contemplated by this Agreement and compliance with its provisions by the Purchaser will not violate any provision of law and will not conflict with or result in any breach of any of the terms, conditions or provisions
of, or constitute a default under, or require a consent or waiver under its organizational documents, or any indenture, lease, agreement or other instrument to which the Purchaser is a party or by which he or it or any of his or its properties is
bound, or any decree, judgment, order, statute, rule or regulation applicable to the Purchaser. 
 3.7
Disclosure of Information. The Purchaser has had an opportunity to visit and inspect the properties of the Company, including its corporate and financial records, and to discuss the Company’s business, management, financial affairs and
the terms and conditions of the offering of the Securities with the Company’s management. The foregoing, however, does not limit or modify the representations or warranties of the Company in Section 2 of this Agreement or the right
of the Purchaser to rely thereon. 
 4. Covenants of the Company. 

4.1 Material Changes and Litigation. The Company will promptly notify the Purchaser of any material adverse change
in the business, prospects, assets or condition, financial or otherwise, of the Company and of any litigation or governmental proceeding or investigation 

  
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brought or, to the best of the Company’s knowledge, threatened against the Company, or any officer, director, key employee or principal stockholder of the Company materially adversely
affecting or which, if adversely determined, could materially adversely affect its business, prospects, assets or condition, financial or otherwise. 
 4.2 Reservation of Capital Stock. In accordance with Section 2.2 of this Agreement, the Company shall reserve and maintain a sufficient number of shares of capital stock for issuance
upon conversion of the Notes. 
 4.3 Termination of Covenants. The covenants of the Company contained in
this Article 4 will terminate, and be of no further force or effect, upon the earlier of (a) an “Equity Financing” (as defined in the Note), (b) a “Change in Control” (as defined in the Note) or “Liquidation
(as defined in the Note), (c) the repayment in full by the Company of all principal outstanding under the Notes and all accrued but unpaid interest thereof, or (d) the effective date of a registration statement filed by the Company under
the Securities Act covering the Company’s first public offering of common stock, resulting in gross proceeds to the Company of at least $50,000,000. 
 5. Transfer of Shares. 
 5.1 Restricted Stock.
“Restricted Stock” means the Securities and any other shares of capital stock of the Company issued in respect of the Securities (as a result of stock splits, stock dividends, reclassifications, recapitalizations, or similar events)
and any shares of capital stock issued upon conversion of such shares; provided, however, that shares of preferred stock (or any shares of common stock into which such shares of preferred stock may be converted or exercised) which are
Restricted Stock will cease to be Restricted Stock (i) upon any sale pursuant to an effective registration statement under the Securities Act, Section 4(1) of the Securities Act or Rule 144 under the Securities Act or (ii) at
such time as they become eligible for sale under Rule 144(k) under the Securities Act. 
 5.2 Requirements for
Transfer. The Restricted Stock may only be sold or transferred in compliance with an effective registration statement covering the Securities, or pursuant to an exemption under the Securities Act and all applicable state securities laws.

 5.3 Legend. Each certificate representing Restricted Stock will bear a legend substantially in the
following form: 
 “The shares represented by this certificate have not been registered under the Securities Act of 1933, as
amended, or any state securities laws, and may not be offered, sold or otherwise transferred, pledged or hypothecated unless and until such shares are registered under such Act and any applicable state securities laws or an opinion of counsel
satisfactory to the Company is obtained to the effect that such registration is not required.” 
 5.4
Rule 144A Information. The Company agrees, upon the request of the Purchaser, to make available to the Purchaser and to any prospective transferee of any Restricted Stock of the Purchaser the information concerning the Company described in
Rule 144A(d)(4) under the Securities Act. 

  
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 6. Miscellaneous. 

6.1 Survival of Representations and Warranties. Unless otherwise set forth in this Agreement, the representations,
warranties and covenants of the Company and the Purchasers contained in or made pursuant to this Agreement shall survive the execution and delivery of this Agreement and the Closing until the second anniversary of the date of the Initial Closing.

 6.2 Subordination. The Notes and the indebtedness, rights and obligations evidenced thereby and any
liens or other security interests securing such rights and obligations are subordinate in the manner and to the extent set forth in that certain Subordination Agreement (as amended, restated, supplemented or modified from time to time, the
“Subordination Agreement”), dated as of May 3, 2012, by and among the Subordinated Lender identified therein and MidCap Financial SBIC, LP, in its capacity as agent for certain lenders (together with its successors and assigns,
“Agent”), to certain indebtedness, rights and obligations of the Company to Agent and Lenders (as defined therein) and all liens and security interests of Agent securing the same all as described in the Subordination Agreement, and
each Purchaser and transferee of this instrument, by its acceptance hereof, irrevocably agrees to be bound by the provisions of the Subordination Agreement.” 

6.3 Expenses. All reasonable costs and expenses, including fees and disbursements of one counsel for Purchasers,
incurred by it in connection with the negotiation, preparation, execution and delivery of this Agreement and the closing of the transactions contemplated hereby, shall be paid by the Company. 

6.4 Notices. All notices, requests, consents, and other communications under this Agreement will be in writing and
will be delivered by hand or mailed by first class certified or registered mail, return receipt requested, postage prepaid, or sent by confirmed facsimile or transmission by electronic mail or by nationally recognized overnight courier (i) in
the case of the Purchasers, as provided on the signature page attached hereto; and (ii) in the case of the Company, as provided on the signature page attached hereto, with a copy to Lowenstein Sandler PC, 65 Livingston Ave., Roseland, NJ 07068,
Attention: Michael Lerner. Notices provided in accordance with this Section 6.4 will be deemed delivered upon personal delivery or three (3) business days after deposit in the mail or the next succeeding business day when sent by confirmed
facsimile, electronic transmission or nationally recognized overnight courier. 
 6.5 Brokers. Each of the
Company and the Purchasers (i) represents and warrants to the other parties hereto that he or it has retained no finder or broker in connection with the transactions contemplated by this Agreement, and (ii) will indemnify and save the
other parties harmless from and against any and all claims, liabilities or obligations with respect to brokerage or finders’ fees or commissions, or consulting fees in connection with the transactions contemplated by this Agreement asserted by
any person on the basis of any statement or representation alleged to have been made by such indemnifying party. 

6.6 Entire Agreement; Counterparts. This Agreement and the Notes embody the entire agreement and understanding
between the parties hereto with respect to the subject matter hereof and supersede all prior agreements and understandings relating to such subject matter. This Agreement may be executed in one or more counterparts, each of which will constitute the
Agreement. 

  
 -5-

 6.7 Confidentiality. Each Purchaser hereto agrees that, except
with the prior written permission of the Company, it shall at all times hold in confidence and trust and not use or disclose any confidential information of the Company provided to or learned by such Purchaser in connection with the Purchaser’s
rights under the Agreement, unless such confidential information (a) is known or becomes known to the public in general (other than as a result of a breach of this Section 6.7 by such Purchaser), (b) is or has been independently
developed or conceived by the Purchaser without use of the Company’s confidential information, or (c) is or has been made known or disclosed to the Purchaser by a third party without a breach of any obligation of confidentiality such third
party may have to the Company. Notwithstanding the foregoing, each Purchaser may disclose any confidential information of the Company provided to or learned by such Purchaser in connection with such rights to the minimum extent necessary (i) to
accountants, accountants, consultants, and other professionals to the extent necessary to obtain their services in order to evaluate or monitor such Purchaser’s investment in the Company; (ii) as required by any court or other governmental
body, provided that such Purchaser provides the Company with prompt notice of such court order or requirement to the Company to enable the Company to seek a protective order or otherwise to prevent or restrict such disclosure; (iii) to legal
counsel of such Purchaser; (iv) in connection with the enforcement of this Agreement or rights under this Agreement; (v) to comply with applicable law or (vi) to any existing or prospective affiliate, partner, member, stockholder, or
wholly owned subsidiary of such Purchaser in the ordinary course of business, provided that such Purchaser informs such person that such information is confidential and directs such person to maintain the confidentiality of such information. The
provisions of this Section 6.7 shall be in addition to, and not in substitution for, the provisions of any separate nondisclosure agreement executed by the parties hereto with respect to the transactions contemplated hereby. 

6.8 Future Agreements. Each of the Purchasers herby agree that, in connection with the issuance of the Equity
Securities upon conversion of the Notes, if requested by the Company, such Purchaser shall execute any stock purchase agreement, investors rights agreement, right of first refusal and co-sale agreement, voting agreement or other stockholders
agreement as may be entered into by the investors in connection with a Qualified Equity Financing. 
 6.9
Anti-dilution of Optionholders; Conversion of Notes. Immediately prior to the conversion of the Notes (the “Note Conversion”), the Purchasers, who also hold shares of capital stock of the Company, hereby agree to vote their
shares and to take all other actions appropriate or necessary to (x) prevent the Note Conversion from causing dilution of the outstanding optionholders, including voting to approve (i) an amendment to the 2004 Equity Compensation Plan, as
amended (the “Plan”), to increase the aggregate number of shares of Common Stock authorized for issuance under the Plan in an amount necessary to prevent the dilution of the outstanding optionholders in connection with the Note
Conversion, and (ii) a charter amendment to the Company’s certificate of incorporation to increase the number of authorized shares of Common Stock in connection with the increase in number of shares reserved for issuance under the Plan;
and (y) approve an amendment to the Company’s certificate of incorporation to provide a sufficient number of shares of Equity Securities in connection with the conversion of the Notes. 

6.10 Amendments; Waivers. Any provision of this Agreement (and the Notes issued pursuant to the terms and
conditions of this Agreement) may only be amended or waived by an instrument in writing executed by the Company and Purchasers holding at least a majority of the aggregate principal amount of the Notes sold hereunder; provided however, that such
amendment or waiver shall thereafter apply to this Agreement and all outstanding Notes. 

  
 -6-

 6.11 Severability. The invalidity or unenforceability of any
provision of this Agreement will not affect the validity or enforceability of any other provision of this Agreement. 
 6.12 Titles and Subtitles. The titles and subtitles used in this Agreement are used for convenience only and are not to be considered in construing or interpreting this Agreement. 

6.13 Governing Law. This Agreement will be governed by and construed in accordance with the laws of the State of
Delaware without respect to the principles of the choice of law or the conflict of laws. 
 6.14 Binding
Effect; Assignment. The terms and conditions of this Agreement shall be binding upon and inure to the benefit of the Company and the Purchasers and their respective heirs, successors and assigns. 

6.15 Non-Waiver. The failure of any party to this Agreement to enforce or exercise any right or remedy provided in
this Agreement or at law or in equity upon any default or breach shall not be construed as waiving the rights to enforce or exercise such or any other right or remedy at any later date. No exercise of the rights and powers granted in or held
pursuant to this Agreement by any party hereto, and no delays or omissions in the exercise of such rights and powers shall be held to exhaust the same or be construed as a waiver thereof, and every such right and power may be exercised at any time
and from time to time. 
 [Signature Pages Follow] 

  
 -7-

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

	
	 THE COMPANY:
  

REGADO BIOSCIENCES, INC.

	
	/s/ David J. Mazzo
	Name: David J. Mazzo, Ph.D
	Title: President and CEO

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	 PURCHASERS:
  

DOMAIN PARTNERS VI, L.P.
  

By: One Palmer Square Associates VI, L.L.C.
 Its
General Partner

		
	By:	 	/s/ Kathleen Schoemaker
	Name:	 	Kathleen Schoemaker
	Title:	 	Managing Member
		
	Address:	 	 One Palmer Square

Princeton, NJ 08542

	Telephone:	 	(609) 683-5656
	Fax:	 	(609) 683-9789
	Email:	 	schoemaker@domainvc.com
	
	 QUAKER BIOVENTURES, L.P.
  

By: Quaker Bioventures Capital, L.P.
 Its General
Partner
  
 By: Quaker Bioventures Capital, LLC

Its General Partner

		
	By:	 	/s/ Sherrill Neff

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
 PURCHASERS: 
  

			
	 AURORA VENTURES V, L.P.
  

By: A.V. Management V, L.L.C.
 Its Managing
Member

		
	By:	 	/s/ B. Jefferson Clark
	Name:	 	B. Jefferson Clark
	Title:	 	Manager

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
 PURCHASERS: 
  

			
	 CAXTON ADVANTAGE LIFE SCIENCES FUND, L.P.

 
 By: Caxton Advantage Venture Partners, L.P.

Its General Partner
  
 By: Advantage Life Sciences Partners, LLC
 Its Managing General Partner

		
	By:	 	/s/ Eric Roberts
	Name:	 	Eric Roberts
	Title:	 	Member

 IN WITNESS WHEREOF, the parties have executed this Agreement as of the date first written
above. 
  

			
	 PURCHASERS:
  

BIODISCOVERY 3 FCPR
  
 By: Edmond de Rothschild Investment Partners
 its management company

		
	By:	 	/s/ Raphael Wisniewski
	Name:	 	Raphael Wisniewski
	Title:	 	Directeur Associé

 
	
	
	    /s/ Robert Kierlin
	Robert Kierlin, Individually

 EXHIBIT A 

TO 

CONVERTIBLE NOTE PURCHASE AGREEMENT 
 Schedule of Purchasers 
  

					
	 Name and Address of Purchaser
	  	Initial Closing
May 3,
2012	 
	 Domain Partners VI, L.P.
	  	$	1,780,469	  
	 Quaker Bioventures, L.P.
	  	$	375,000	  
	 Robert Kierlin
	  	$	2,800,071	  
	 Aurora Ventures V, L.P.
	  	$	375,000	  
	 Caxton Advantage Life Sciences Fund, L.P.
	  	$	200,000	  
	 BioDiscovery 3 FCPR
	  	$	1,250,000	  
		  	  
	  
	 
	 TOTAL
	  	$	6,780,540

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