Document:

Employment Agreement, Terrance Snutch

 Exhibit 10.50 
 EMPLOYMENT AGREEMENT 
 THIS EMPLOYMENT AGREEMENT (this “Agreement”) effective as of 1st day
of July 2007, is entered into by and between Neuromed Pharmaceuticals Ltd., a company incorporated under the laws of British Columbia (together with its subsidiaries, the “Company” or “Neuromed”), and Dr. Terrance
Snutch (“Dr. Snutch”), an individual residing in British Columbia (the “Executive”). 
 W I T N E S S E T H:

 WHEREAS, 
 The
Company and Dr. Snutch entered into an agreement (the “First Employment Agreement”) on March 2, 1998 and then later amended the agreement on November 30, 1998 (the “Second Employment Agreement”), and then later
amended the agreement on the 30th day of November, 2000 (the “Third
Agreement”) and then later amended the agreement on May 17, 2001 (the “Fourth Agreement”) to record the terms and conditions to govern the employment of Dr. Snutch by the Company from and after May 17, 2001. 
 The Company and Dr. Snutch wish to amend and replace the Fourth Employment Agreement with a new agreement (the “Agreement”) which will set
out the amended terms and conditions which will govern the employment of Dr. Snutch by the Company from and after the Effective Date of this Agreement and which shall retroactively amend and replace certain terms of the Third Employment
Agreement. 
 NOW THEREFORE in consideration of the mutual benefits to be derived from this Agreement, the Company and the Executive hereby
agree as follows: 
  

	1.	Term of Employment; Duties; Necessary Agreements. 

 (a) The Company hereby agrees to continue to employ Dr. Snutch and, subject to termination in accordance with the provisions of paragraph 4 hereof, the Company shall employ the Executive with the title of Vice President and Chief
Scientific Officer, with the duties and responsibilities prescribed for such office in his job description, as well as such additional duties and responsibilities consistent with such position as may from time to time be assigned to the Executive by
the President & Chief Executive Officer of Neuromed. 
 As Vice President and Chief Scientific Officer, Executive shall perform such duties and
exercise such powers commensurate with his office which will include but are not limited to the following 
  

	 	(i)	leading, proposing plans and directions for and directing the scientific, research and development activities of the Company; 

	 	(ii)	keeping the Board informed as to all matters concerning the Company’s activities; and 

  

	 	(iii)	meeting the performance standards that may be reasonably prescribed, from time to time, for Dr. Snutch by the Board or Neuromed’s President & CEO.

 Executive agrees to perform all his duties and discharge such responsibilities in a competent, professional
and ethical manner, and in accordance with the terms of this Agreement. 
 (b) It is acknowledged that Dr. Snutch is a full Professor at
the University of British Columbia (“UBC”), that it is in the best interests of the Company for Dr. Snutch to maintain that position, and that Dr. Snutch will devote an appropriate amount of time to the business and affairs of
the Company in order to perform all the duties of his positions with the Company and UBC, other than during vacations and periods of illness or incapacity; provided, however, that nothing in this Agreement shall preclude the Executive from devoting
time required to: (i) maintain the directorships and other responsibilities now held by him as well as such additional directorships as may be approved, from time to time, by Neuromed’s President & CEO ; or (ii) engaging in
charitable and community activities approved in advance by Neuromed’s President & CEO and provided that Neuromed continues to determine that Executive’s participation in such activities does not interfere with the performance of
his duties hereunder. 
 (c) The terms of the Assignment of Inventions, Work Practises and Confidentiality Agreement November 30, 1998
between Dr. Snutch and the Company shall continue in full force and effect and shall form part of this Employment Agreement. 
  

	2.	Compensation and Benefits. 

 For all services
rendered by the Executive in any capacity during the period of Executive’s employment by the Company, including without limitation, services as an executive officer or member of any committee of the Board of Directors or any subsidiary,
affiliate or division thereof, from and after the Effective Date, the Executive shall be compensated as follows: 
 (a)
Base Salary. Effective January 1, 2007, the Company shall pay the Executive a base salary (“Base Salary”) at a rate of Two Hundred Eleven Thousand Dollars ($219,000) per year. The individual to whom the Executive shall report
may periodically review the Executive’s Base Salary and may determine to increase the Executive’s salary, in accordance with such policies as the Company may hereafter adopt from time to time, if it deems appropriate. Base Salary will be
payable in accordance with the customary payroll practices of the Company. 
 (b) Incentive Compensation. Executive
will be eligible to receive an annual performance bonus (the “Performance Bonus”). The final determination on whether or not a Performance Bonus is paid, or the amount of any Performance Bonus, will be made by the 

  

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Board of Directors in its sole discretion, based upon the achievement of mutually agreed upon performance goals, and other subjective factors. Executive is
eligible for a Performance Bonus of up to forty percent (40%) of his Base Salary. In order to be eligible for any Performance Bonus in any given year, Executive must be on the active payroll of Company on the date that such Performance Bonus is
or would have been paid out. 
 (d) Fringe Benefits, Option Grants and Miscellaneous Employment Matters. The Executive
shall be entitled to participate in such disability, health and life insurance and other fringe benefit plans or programs, of the Company established from time to time by the Board of Directors, if any, to the extent that his position, tenure,
salary, age, health and other qualifications make him eligible to participate, subject to the rules and regulations applicable thereto. In addition, the Executive shall be entitled to: 
 (i) A monthly car allowance in the amount of $210.00; and 
 (ii) Participate in the Company’s stock option plan, as may be established from time to time, to purchase shares of the
Company’s Common Stock, based on fair market value as maybe established by the Board of Directors in its reasonable discretion, to the extent such participation is approved by the Board of Directors. As a condition precedent to Executive’s
receipt of, and vesting in, any of the above-referenced Option Grants, Executive must be on the active payroll of Company on the date that such Option Grants did or would have vested. 
 (e) Withholding and Employment Tax. Payment of all compensation hereunder shall be subject to customary withholding tax and other
employment taxes as may be required with respect to compensation paid by an employer/corporation to an employee. 
 (f)
Travel and Expenses. The Company shall pay or reimburse reasonable expenses incurred by the Executive in connection with the performance of his duties under this Agreement, as may be required and approved by the individual to whom Executive
reports. All expenses shall be submitted in writing within thirty (30) days after they are incurred, be consistent with duly approved Company budgets, and shall be in accordance with such policies and procedures for documentation as the Company
may from time to time establish and as the Company determines is required to preserve any deductions for income taxation purposes to which the Company may be entitled. 
 (g) Vacation. Executive shall receive four (4) weeks of vacation annually, administered in accordance with the Company’s
existing vacation policy. 
 (h) No other amounts. The Executive acknowledges and agrees that unless otherwise
expressly agreed in writing between the Executive and the Company, the Executive shall not be entitled, by reason of employment with the Company, to any remuneration, compensation or benefits other than those expressly provided for in this
agreement. 
  

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	3.	Other Obligations of Neuromed. 

 (a) Neuromed shall
maintain, perform and provide, at its expense, such offices and equipment, supplies, furniture, and fixtures, as it determines are reasonably necessary for the performance of services by Executive. 
 (b) The Company will indemnify the Executive to the fullest extent permitted by the Certificate of Incorporation and Bylaws of the Company, as in effect
at such time or on the date of this Agreement, whichever affords greater protection to the Executive, and the Executive shall be entitled to the protection of any insurance policies the Company may elect to maintain generally for the benefit of its
executive officers except that the Company shall have no obligation to indemnify Executive for liabilities resulting from conduct of the Executive with respect to which a court of competent jurisdiction has made a final determination that Executive
committed gross negligence or willful misconduct, or engaged in an illegal act. 
  

	4.	Termination of Employment. 

 Notwithstanding any
other provision of this Agreement, Executive’s employment with the Company may be terminated at any time, by either the Executive or the Company, upon written notice to the other party as follows: 
 (a) By the Company, in the event of the Executive’s death or Disability (as hereinafter defined) or for Cause (as hereinafter
defined). For purposes of this Agreement, “Cause” shall mean either: (i) the indictment of, or the bringing of formal charges against, Executive by a governmental authority of competent jurisdiction for charges involving fraud or
embezzlement; (ii) the conviction of Executive of a crime involving an act or acts of dishonesty, fraud or moral turpitude by the Executive; (iii) Executive having willfully caused the Company, to fail to abide by either a valid contract
or any principle of scientific integrity and ethics; (iv) Executive having committed acts or omissions constituting gross negligence or willful misconduct with respect to the Company; (v) Executive having committed acts or omissions
constituting a material breach of Executive’s obligations under this Agreement or of Executive’s duty of loyalty or fiduciary duty to the Company or any material act of dishonesty or fraud with respect to the Company. For purposes of this
Agreement, “Disability” shall mean the inability of Executive, in the reasonable judgment of a physician appointed by the Company, to perform his duties of employment for the Company or any of its subsidiaries because of any physical or
mental disability or incapacity, where such disability shall exist for an aggregate period of more than 180 days in any 365-day period, or for any period of 90 consecutive days. The Company shall by written notice to the Executive specify the event
relied upon for termination pursuant to this Section 4(a), and Executive’s employment hereunder shall be deemed terminated as of the date of such notice. In the event of any termination under this Subsection 4(a), the Company shall pay all
amounts then due to the Executive under Section 2(a) of this Agreement for any portion of the payroll period worked but for which payment had not yet been made up to the date of termination, and, if such termination was for Cause, the Company
shall have no further obligations to Executive under 

  

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this Agreement, and any and all options granted hereunder shall terminate according to their terms. 
 (b) By the Company, in the absence of Cause, for any reason and in its sole and absolute discretion, provided that in such event the
Company shall, as liquidated damages or severance pay, or both, continue to pay to Executive the Base Salary, together with the Performance Bonus earned in the previous twelve month period, (at a monthly rate equal to the rate in effect immediately
prior to such termination) for twelve months from the date of termination (the “Termination Payments”), when, as and if such payments would have been made in the absence of Executive’s termination. Executive understands and agrees
that the Company’s obligation to make any Termination Payments is expressly conditioned upon Executive’s execution of a general release agreement, in a form reasonably prescribed by the Company. 
 (c) By the Executive, with or without reason, and upon sixty (60) days advance written notice to Company. 
 (d) By the Executive upon a material breach or default of any term of this Agreement by the Company if such material breach or default has
not been remedied to the satisfaction of the Executive within 21 days after written notice of the material breach or default has been delivered by the Executive to the Company. In the event of termination of the Executive’s employment pursuant
to this subsection 4 (d) or the Company terminating the Executive in breach of this Agreement, the Company shall make termination payments in accordance with subsection 4 (b). 
 (e) By the Executive for “Good Reason” at any time within 180 days of the date on which there is a Change in Control. For the
purposes of this Section 4, “Good Reason” shall mean the occurrence of the following, if the same shall occur without the Executive’s prior consent 
  

	 	(i)	a material reduction in the duties of the Executive, or the permanent assignment to the Executive of duties substantially unsuited to the Executive’s level of experience or
qualifications; 

  

	 	(ii)	a material reduction of the Executive’s Annual Salary, Performance Bonus eligibility or Benefits; or 

  

	 	(iii)	a relocation of the Executive’s principle place of work to a location outside of the Greater Vancouver Regional District. 

 In the event of termination of the Executive’s employment pursuant to this subsection 4 (e) the Company shall make termination payments in accordance with
subsection 4 (b). 
  

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	5.	Survival of Obligations. 

 Executive’s
obligations under the terms of the Assignment of Inventions, Work Practises and Confidentiality Agreement November 30, 1998 shall survive the termination for any reason of this Agreement (whether such termination is by the Company, by the
Executive, upon a change of control of the Company, upon the expiration of this Agreement or otherwise). 
  

	6.	Executive’s Representations. 

 The Executive
hereby represents and warrants to the Company that (i) the execution, delivery and performance of this Agreement by the Executive do not and shall not conflict with, breach, violate or cause a default under any contract, agreement, instrument,
order, judgment or decree to which the Executive is a party or by which he is bound and (ii) upon the execution and delivery of this Agreement by the Company, this Agreement shall be the valid and binding obligation of the Executive,
enforceable in accordance with its terms. The Executive hereby acknowledges and represents that he has had the opportunity to consult with legal counsel regarding his rights and obligations under this Agreement and that he fully understands the
terms and conditions contained herein. 
  

	7.	Enforcement. 

 Because the Executive’s services
are unique and because the Executive has access to confidential information concerning the Company, the parties hereto agree that money damages would not be an adequate remedy for any breach of this Agreement. Therefore, in the event of a breach or
threatened breach of this Agreement, the Company may, in addition to other rights and remedies existing in its favor, apply to any court of competent jurisdiction for specific performance and/or injunctive or other relief in order to enforce, or
prevent any violations of, the provisions hereof (without posting a bond or other security). 
  

	8.	Severability. 

 In case any one or more of the
provisions or part of a provision contained in this Agreement or any attachment hereto shall for any reason be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability shall be deemed not to affect
any other provision or part of a provision of this Agreement, nor shall such invalidity, illegality or unenforceability affect the validity, legality or enforceability of this Agreement or any provision or provisions hereof in any other
jurisdiction; and this Agreement shall be reformed and construed in such jurisdiction as if such provision or part of a provision held to be invalid or illegal or unenforceable had never been contained herein and such provision or part reformed so
that it would be valid, legal and enforceable to the maximum extent possible. If, in any judicial proceeding, a court shall refuse to enforce any of such separate covenants, then such unenforceable covenants shall be deemed eliminated from the
provisions hereof for the purpose of such proceedings to the extent necessary to permit the remaining separate covenants to be enforced in such proceedings. If, in any judicial proceeding, a court shall 

  

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refuse to enforce any one or more of such separate covenants because the total time, scope or area thereof is deemed to be excessive or unreasonable, then it
is the intent of the parties hereto that such covenants, which would otherwise be unenforceable due to such excessive or unreasonable period of time, scope or area, be enforced for such lesser period of time, scope or area as shall be deemed
reasonable and not excessive by such court. 
  

	9.	Entire Agreement; Amendment. 

 Except as otherwise
set forth in this Agreement, this Agreement contains the entire agreement between the Company and the Executive with respect to the subject matter hereof and thereof. This Agreement may not be amended, waived, changed, modified or discharged except
by an instrument in writing executed by or on behalf of the party against whom enforcement of any amendment, waiver, change, modification or discharge is sought. No course of conduct or dealing shall be construed to modify, amend or otherwise affect
any of the provisions hereof. 
  

	10.	Notices. 

 All notices, requests, demands and other
communications hereunder shall be in writing and shall be deemed to have been duly given if physically delivered, delivered by express mail or other expedited service or upon receipt if mailed, postage prepaid, via registered mail, return receipt
requested, addressed as follows: 
  

	 	(a)	To the Company: 

 Bruce Colwill 
 VP Finance & Chief Financial Officer 
 Neuromed Pharmaceuticals Ltd. 
 301-2389 Health Sciences Mall 
 Vancouver, British Columbia 
 V6T 1Z4 Canada

  

	 	(b)	To the Executive: 

 3963 West 24th Avenue 
 Vancouver, British Columbia 
 V6S 1M1 Canada

 and/or to such other persons and addresses as any party shall have specified in writing to the other. 
  

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	11.	Assignability. 

 This Agreement is for personal
services to be performed by Executive and may not be assigned or transferred by Executive, or the obligations of Executive performed by any other party. All of the rights and obligations of the Company under this Agreement are fully assignable and
transferable by the Company. In the event that all or substantially all of the business of the Company is sold or transferred, Executive agrees that, subject to subsection 4(e), this agreement and his Assignment of Inventions, Work Practises and
Confidentiality Agreement shall be assigned to the transferee and shall be binding upon both Executive and transferee. 
  

	12.	Governing Law. 

 This Agreement shall be governed by
and construed under the laws of the Province of British Columbia. 
  

	13.	Waiver and Further Agreement. 

 Any waiver of any
breach of any terms or conditions of this Agreement shall not operate as a waiver of any other breach of such terms or conditions or any other term or condition, nor shall any failure to enforce any provision hereof operate as a waiver of such
provision or of any other provision hereof. Each of the parties hereto agrees to execute all such further instruments and documents and to take all such further action as the other party may reasonably require in order to effectuate the terms and
purposes of this Agreement. 
  

	14.	Headings of No Effect. 

 The paragraph headings
contained in this Agreement are for reference purposes only and shall not in any way affect the meaning or interpretation of this Agreement. 
  

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 IN WITNESS WHEREOF, the parties hereto have executed this Employment Agreement as of the date first above
written. 
  

			
	COMPANY:
	
	NEUROMED PHARMACEUTICALS LTD.
		
	By:	 	/s/ Christopher Gallen
		 	Christopher Gallen
		 	President & CEO
	
	EXECUTIVE:
	
	/s/ Terrance Snutch, Ph.D.
	Terrance Snutch, Ph.D.

  

 9Assignment of Inventions, Work Practices and Confidentiality Agreement

 Exhibit 10.51 
 NEUROMED TECHNOLOGIES INC. 
 November 30, 1998 
 Dr. Terry Snutch 
 3963 West 24th Avenue 
 Vancouver, British Columbia 
 V6S 1M1 
 Dear Dr. Snutch 
 Assignment of Inventions, Work
Practises and Confidentiality Agreement 
 You and NeuroMed Technologies Inc. (“NeuroMed”) entered into an agreement (the
“First Agreement”) on March 2, 1998 to record the terms and conditions pursuant to which you, as an employee of NeuroMed would receive from NeuroMed proprietary information and pursuant to which you agreed to keep the information
confidential and to protect it from disclosure. 
 You have agreed to amend and replace the First Agreement with a new agreement (the
“Agreement”) which will set out the amended terms and conditions pursuant to which you, as an employee of NeuroMed will receive from NeuroMed confidential and proprietary information (as hereinafter defined) and pursuant to which you agree
to keep the information confidential and to protect it from disclosure. The Agreement will govern the receipt and use by you of information received from NeuroMed from and after the date of this Agreement and shall retroactively amend and replace
the First Agreement. 
 The purpose of this letter is to confirm and record the terms of the Agreement between you and NeuroMed concerning
the terms on which, as an employee of NeuroMed, you will receive from NeuroMed information and pursuant to which you agree to keep the information confidential and to protect it from disclosure. NeuroMed and any affiliated companies and associated
persons will be collectively referred to in this letter as “NeuroMed”. 
 You and NeuroMed hereby agree as follows: 

 Definitions - In this Agreement: 
  

	1.1	“Confidential Information” means confidential information of NeuroMed disclosed to you by NeuroMed, which shall include but not be limited to proprietary assays,
screening strategies and technologies, targets for drug discovery, chemical formulae, commercial and financial information concerning the corporate and scientific and pharmaceutical research activities and plans of NeuroMed and includes all
Proprietary Developments. 

  

	1.2	“NeuroMed’s Business” means the specific biomedical research and development activities conducted by NeuroMed including the discovery and development of novel
calcium channel blockers for the purpose of treating neurological diseases; 

  

	1.3	“Proprietary Development” means a development or developments including, without limitation; 

  

	 	(a)	enhancements, modifications, additions or other improvements to the intellectual property or assets owned, license, sold, marketed or used by NeuroMed in connection with
NeuroMed’s Business; 

  

	 	(b)	trademarks, copyrights, trade names, business names, logos, design marks and other proprietary marks; 

  

	 	(c)	inventions, devices, discoveries, concepts, ideas, formulae, know-how, processes, techniques, systems, methods and any and do improvements, enhancements and modifications thereto,
whether patented or not; 

 developed, created, generated, contributed to or reduced to practice by you alone or jointly with
others pursuant to your activities as an employee, director, officer or consultant of NeuroMed and which results from tasks assigned to you by NeuroMed or which results from the use of the premises or property (including equipment, supplies or
Confidential Information) owned, leased or licensed by NeuroMed and which reasonably relates to the NeuroMed Business. 
  

	1.4	“Affiliated” shall have the meaning ascribed to that term under the Canada Business Corporations Act RSC, 1985, C.44, as amended. 

 

	2.	Confidentiality 

  

	2.1	 Basic Obligation Of Confidentiality - In consideration of the payment by us to you of the sum of $10 and for other good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, you acknowledge and agree that in the course of your involvement with NeuroMed’s Business, NeuroMed may disclose to you or you may otherwise be exposed to NeuroMed’s Confidential Information.
NeuroMed agrees to provide such access to you and you agree to receive and hold the Confidential Information on the terms and conditions set out herein. Except as set out below, you will keep strictly confidential all Confidential Information and
all other information that you acquire, see, or are informed of, as a direct or indirect consequence of your involvement with NeuroMed in any capacity or that is revealed to you by NeuroMed or is generated through negotiations or 

  

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other activities of the parties in connection with your involvement, in any capacity, with NeuroMed’s Business. 

  

	2.2	Fiduciary Relationship. You will be and act toward NeuroMed as a fiduciary and you will not use, duplicate, publish, or disclose at any time, either during or after your
involvement in any capacity with NeuroMed, any of the Confidential Information, whether or not conceived, originated, discovered, or developed in whole or in part by you. The restrictions in this paragraph will not apply to information received by
you from NeuroMed only when and to the extent a particular item ceases to fit within the definition of Confidential Information set out above or as determined by a Court of competent jurisdiction. 

  

	2.3	Non-disclosure. Unless NeuroMed first gives you written permission to do so, you will not: 

  

	 	(a)	use or duplicate Confidential Information or recollections thereof; 

  

	 	(b)	disclose Confidential Information or recollections thereof to any third party; or 

  

	 	(c)	translate or adapt any Confidential Information or permit any Confidential Information to be used, copied, translated or adapted except as otherwise expressly permitted by this
Agreement or by NeuroMed in a written instrument signed by an authorised officer of NeuroMed. 

  

	2.4	Exemptions From Confidential Information. Confidential Information shall not include information that; 

  

	 	(a)	is, at the date hereof or hereafter, in the public domain without misappropriation, wrongful appropriation of trade secrets, breach of contractual or fiduciary obligation or
infringement and through no fault of yours; 

  

	 	(b)	is, after the date hereof, properly obtained by you from a third party ,which party has a valid legal right to disclose such information to you and which party is not under a
confidentiality obligation to NeuroMed; or 

  

	 	(c)	is required to be disclosed by law, court order or regulatory process, if NeuroMed is given sufficient notice of any such proceeding or requirement to dispute the obligation to
disclose; 

 provided, however, that you will bear the burden of proving reliance upon the foregoing exceptions. 
  

	3.	Moral Rights. The Company, its assignees and its licensees, are not required to designate you as the author of any Proprietary Developments. You hereby waive in whole all
moral rights, and agree never to assert any moral rights which you may have, in any proprietary Developments, including, without limitation, the right to the integrity of any Proprietary Developments, the right to restrain or claim damages for any
distortion, mutilation or other modification or enhancement of any Proprietary Developments and the right to restrain, use or reproduce any Proprietary Developments in any context and in connection with any product, service, cause or institution and
you further confirm that the Company may use or alter any such Proprietary Developments as the Company sees fit in its absolute discretion. 

  

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	4.	Taking Precautions. You will take all reasonable precautions necessary or prudent to prevent material in your possession or control that contains or refers to Confidential
Information from being discovered, used, or copied by third parties. 

  

	5.	NeuroMed’s Ownership of Confidential Information. As between you and NeuroMed, all right, title and interest in and to the Confidential Information, whether or not
created or developed by you, is and shall remain NeuroMed’s property. 

  

	6.	Control of Confidential Information and Return of Information. All physical materials produced or prepared by you containing Confidential Information, including designs,
formula, memoranda, test results and notes of experiments, drawings, plans, prototypes, samples, accounts, reports, financial statements or proforma estimates and any other materials prepared in the course of your responsibilities or for the benefit
of NeuroMed shall belong to NeuroMed, and you will turn over possession to NeuroMed of all such items in your possession or control promptly when NeuroMed requests you to do so. 

  

	7.	Purpose of Use. You will use Confidential Information only for purposes authorised or directed by NeuroMed and its officers and you will not seek access to any Confidential
Information that is not relevant to or necessary for those purposes. Such purposes are referred to in this Agreement as the “Permitted Use”. 

  

	8.	Duration of Obligation. Except as NeuroMed agrees otherwise in a written instrument signed by an authorised officer of NeuroMed, your obligations of confidentiality under
this Agreement shall subsist for the longer of: 

  

	8.1	ten years after the termination of your involvement with NeuroMed; and 

  

	8.2	with respect to particular items of Confidential Information or material, for so long as those items are not in the public domain, but your obligations will continue if those items
enter the public domain as a consequence of a breach of this Agreement or any other wrongful or negligent act or omission of you required by law are subject to a protective order. 

  

	9.	Warranty of Disclosure. You declare and agree that you have disclosed to NeuroMed inventions or improvements relating to NeuroMed’s Business or to the Confidential
Information which are within your knowledge and possession or power other than those specifically disclosed in writing to NeuroMed on the date of this letter. 

  

	10.	Research Activities Being Carried Out In Dr. Snutch’s Academic Laboratory at UBC. It is acknowledged that you are subject to and bound by the Policy (the
“Policy”) entitled Policy #88 and that you are not in a position to make agreements with respect to intellectual property developed in the Laboratory under your supervision at the University of British Columbia. You agree however, always
in a manner consistent with the Policy, to bring to the attention of the Company any opportunity to obtain rights to an invention or line of research at the University of British Columbia which you think might be of interest to the Company in
carrying out NeuroMed’s Business. 

  

	11.	 Notice of Inventions, Full Disclosure and Assignment. You agree to inform NeuroMed promptly upon creation of any invention of improvement or invention which
you 

  

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develop, invent or discover in the course of your activities as an employee of NeuroMed and which would be relevant to NeuroMed’s Business or research
and development activities. You agree to make full disclosure to NeuroMed of each Proprietary Development, promptly upon its creation. If required by NeuroMed, you will disclose in writing in a log book or such other form of device provided for such
purpose by NeuroMed, the details of all developments that you are involved with or responsible for as an employee of NeuroMed. You will assign, and do hereby irrevocably assign and transfer, to NeuroMed or to NeuroMed’s designee, your entire
right, title and interest in and to all Proprietary Developments to or improvements of any aspect of the Confidential Information or any Proprietary Development including copyrights, formulae, trade secrets, designs, and all other rights and
interests of a proprietary nature in and associated with the Confidential Information or with the Proprietary Developments and all applications filed and patents and other registrations and recordings granted thereon, including those in foreign
countries. To the extent that you own or acquire legal title to any of such items as an employee of NeuroMed, you hereby declare and confirm that such legal title is and will be held by you only as bare trustee and agent for NeuroMed. You agree that
NeuroMed will be the exclusive owner of all of your right title and interest in and to each Proprietary Development throughout the world, including all trade secret patent copyright trademark industrial design and all other intellectual property
rights of any kind and therein. 

  

	12.	Assistance with Assignment. You hereby undertake, at the request of NeuroMed and at NeuroMed’s cost to execute any necessary assignment, patent or copyright forms and
the like, and will assist in the drafting of any description or specification of the invention or improvement as may be required for your records and in connection with any application for letters patent for any NeuroMed invention. NeuroMed will be
exclusively entitled to make applications for registration of all such rights in NeuroMed’s sole discretion in such jurisdictions which NeuroMed deems necessary. Your obligations hereunder will continue beyond a termination of your employment
by NeuroMed respecting Proprietary Developments created during your employ with NeuroMed and are created during the six months immediately following determination of your employment with NeuroMed. 

  

	13.	Assistance with Proceedings. You further agree to lend such assistance as you can at our request and expense in connection with any opposition to, or intervention regarding,
an application for letters patent, copyright or trademark or other proceedings relating to intellectual properties or applications for registrations therefor. During the term of this Agreement and thereafter you agree to execute:

  

	13.1	all instruments that NeuroMed may reasonably require to effect, perfect, register, record, or patent any Proprietary Developments to or improvements of the Confidential Information
or, related rights, or NeuroMed’s interest therein; and 

  

	13.2	all papers that NeuroMed reasonably considers necessary or helpful in obtaining or maintaining such interests and rights during the prosecution of applications thereon or during the
conduct of any interference, litigation, opposition, or any other matter in connection therewith; 

  

	13.3	provided that all expenses incident to such activities will be borne by NeuroMed. 

  

	14.	 Inventions and Improvements. You further agree to treat all information relating to any invention or improvement as Confidential Information owned by
NeuroMed and you will 

  

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disclose same only to your immediate superior or as he or she may direct. You further agree that NeuroMed’s rights hereunder shall attach to any such
invention or improvement notwithstanding that it is perfected or reduced to specific form after you have terminated your relationship with NeuroMed if the conception of the invention or improvement arose as a result of work which was part of your
employment with NeuroMed. In that event NeuroMed will pay to you all costs and expenses which you may incur in assisting NeuroMed to obtain letters patents or other protection. You agree that NeuroMed’s rights under this clause shall not be
limited to this country but shall extend to every country of the world. 

  

	15.	Binding Nature of Agreement. You agree that this Agreement shall be binding upon your personal representatives. 

  

	16.	Equitable Remedies. You acknowledge and agree that a breach by you of any of your obligations hereunder would result in damages to NeuroMed that could not be adequately
compensated for by monetary award. Accordingly, in the event of any such breach by you, in addition to all other remedies available to NeuroMed at law or in equity, NeuroMed shall be entitled as a matter of right to apply to a Court of competent
jurisdiction for such relief by way of restraining order, injunction, decree or otherwise, as may be appropriate to ensure compliance with the provisions of this Agreement. 

  

	17.	Independent Legal Advice. As this is an important agreement for you and for NeuroMed containing significant undertakings by you, NeuroMed urges you to seek independent legal
advice with respect to your obligations under this Agreement. 

  

	18.	Miscellaneous. This Agreement shall be governed by and interpreted in accordance with the laws of the Province of British Columbia, and all disputes under or relating to this
Agreement shall be resolved by referring resolution to a single arbitrator agreed upon by you and NeuroMed, who shall be a scientist with relevant experience in the matter, and resident in North America. If you and NeuroMed are unable to agree upon
a single arbitrator, such arbitrator shall be appointed in accordance with the provisions of the Commercial Arbitration Act (British Columbia) or any re-enactment or amendment thereof. Any Arbitration shall be held in the City of Vancouver. The
procedure followed shall be agreed upon by the parties, or, in default of agreement, determined by the arbitrator. The decision arrived at by the arbitrator shall be final and binding and no appeal shall lie therefrom. The cost of the arbitration
shall be shared equally by you and the Company. The parties will execute and deliver to each other such further instruments and assurances and do such further acts as may be required to give effect to this Agreement. All notices and other
communications that are required or permitted by this Agreement must be in writing and delivered by hand or double-registered mail to the parties at their addresses set out on the first page hereof, or to such other addresses of which the parties
give each other notice. This Agreement supersedes all previous dealings, understandings, and expectations of the parties and constitutes the whole agreement with respect to the matters contemplated hereby, and there are no representations,
warranties, conditions or collateral agreements between the parties with respect to such transactions except as expressly set out herein. No amendment, modification, supplement or other purported alteration of this Agreement shall be binding unless
it is in writing and signed by you and by NeuroMed. 

  

 Page 6 of 9 

	19.	No Other Obligations. You represent, except as you have disclosed to NeuroMed in writing on the date hereof, that you have no agreements with or obligations to others with
respect to the matters covered by this Agreement or concerning the Confidential Information that are in conflict with anything in this Agreement. The parties acknowledge that, during your employment with the Company you will continue as a Professor
and Member of the Faculty of the University of British Columbia and that in those capacities you are associated with and direct an academic research laboratory carrying out research (the “UBC Research”) on calcium channel physiology and
molecular neurobiology and that you are bound by the UBC Patents and Licensing Policy (the “Policy”). 

  

	20.	Non-Competition. You hereby covenant and agree that you shall not while you are a consultant, employee, officer or director of NeuroMed or during the 24 month period after
you cease to be an officer or employee of NeuroMed as a result of your termination of employment, engage in any of the following activities: 

  

	20.1	either directly or indirectly as principal, agent, owner, proprietor, partner, shareholder, director, officer or otherwise own, operate, carry on, be engaged in the operation of,
have any financial interest in, lend any moneys to, guarantee any liabilities or obligations of, act as a consultant to or provide management services to any business operation whether a proprietorship, partnership, joint venture corporation or
otherwise which competes in the NeuroMed Business directly with NeuroMed in North America or anywhere else in the world where NeuroMed markets, sells, licenses or develops its products or services during the term of this Agreement;

  

	20.2	directly or indirectly solicit, interfere with or endeavor to direct or in place away from NeuroMed any customer, client or any person, firm or corporation in the habit of dealing
with NeuroMed; or 

  

	20.3	interfere with, entice away or otherwise attempt to obtain withdrawal of any employees of NeuroMed. 

 The covenants made in this Section 19 are made by you acknowledging that you have specific and extensive knowledge of the affairs of NeuroMed and
that NeuroMed operates and seeks out business in North America and other jurisdictions. You hereby acknowledge and agree that the restrictions contained in this Section are reasonable and valid and that all defenses to strict enforcement thereof are
hereby waived. 
  

	21.	Notification and Execution of Documents. You agree to communicate to NeuroMed promptly and fully all inventions, writings, designs, discoveries, concepts, formulae, processes
and ideas, whether or not patentable, that you invent, author, create, conceive, complete, or reduce to practice, whether solely or jointly with others, during the period of your involvement with NeuroMed that: 

  

	21.1	are related to the present or prospective business activities of NeuroMed or to NeuroMed’s Business; 

  

	21.2	result from any work you perform with the use of any equipment, facilities, materials or personnel of NeuroMed; or 

  

	21.3	result from or are suggested by any work which you may do for or on behalf of NeuroMed. 

  

 Page 7 of 9 

	22.	Publicity. Without the prior written consent of the President of NeuroMed you will not make or give any public announcements or press releases or statements to the public or
the press regarding any Confidential Information or concerning NeuroMed’s Business. 

  

	23.	Severability. If any covenant or provision of this Agreement or of a Section of this Agreement is determined by a Court of competent jurisdiction to be void or unenforceable
in whole or in part, then such void or unenforceable covenant or provision shall not affect or impair the enforceability or validity of the balance of the Section or any other covenant or provision. 

  

	24.	Time Of Essence/No Waiver. Time is of the essence hereof, and no waiver, delay, indulgence, or failure to act by NeuroMed regarding any particular default or omission by you
shall affect or impair any of NeuroMed’s rights or remedies regarding that or any subsequent default or omission that is not expressly waived in writing, and in all events time shall continue to be of the essence without the necessity of
specific reinstatement. 

 Acceptance. 
 If the foregoing terms and conditions are acceptable to you, please indicate your acceptance of and agreement to the terms and conditions of this Agreement by signing below on this letter and on the enclosed copy of
this letter in the space provided and by returning the enclosed copy so executed to us. Your execution and delivery to NeuroMed of the enclosed copy of this letter will create a binding agreement between us. 
 Thank you for your co-operation in this matter. 
  

			
	Yours truly,
	
	NeuroMed Technologies Inc.
		
	per:	 	/s/ Natalie Dakers
		 	(Authorised Signatory)

 Accepted and Agreed to this 30th day of November, 1998: 
  

	
	/s/ Dr. Terry Snutch
	(Dr. Terry Snutch)

  

 Page 8 of 9

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