Document:

EX-10.11

 Exhibit 10.11 

AMENDED AND RESTATED SERIES B CONVERTIBLE PREFERRED STOCK 

PURCHASE AGREEMENT 

VISTERRA, INC. 

September 12, 2014 

 TABLE OF CONTENTS 

 

									
	 	 	 	  	 	  	Page	 
	 1.
	 	 Authorization; Sale and Issuance of Series B Shares and Common Shares
	  	 	2	  
				
		 	 1.1
	  	 Authorization
	  	 	2	  
		 	 1.2
	  	 Sale and Issuance of Shares
	  	 	2	  
		 	 1.3
	  	 Use of Proceeds
	  	 	3	  
			
	 2.
	 	 Representations of the Company
	  	 	3	  
				
		 	 2.1
	  	 Organization; Good Standing and Qualification
	  	 	3	  
		 	 2.2
	  	 Authorization
	  	 	4	  
		 	 2.3
	  	 Valid Issuance of Stock
	  	 	4	  
		 	 2.4
	  	 Governmental Consents
	  	 	5	  
		 	 2.5
	  	 Capitalization
	  	 	5	  
		 	 2.6
	  	 Subsidiaries
	  	 	7	  
		 	 2.7
	  	 Environmental and Safety Laws
	  	 	7	  
		 	 2.8
	  	 Litigation
	  	 	7	  
		 	 2.9
	  	 Intellectual Property
	  	 	7	  
		 	 2.10
	  	 Compliance with Other Instruments
	  	 	8	  
		 	 2.11
	  	 Contracts and Commitments
	  	 	8	  
		 	 2.12
	  	 Related-Party Transactions
	  	 	9	  
		 	 2.13
	  	 Permits
	  	 	10	  
		 	 2.14
	  	 Information Supplied to Purchasers
	  	 	10	  
		 	 2.15
	  	 Corporate Documents
	  	 	10	  
		 	 2.16
	  	 Title to Property and Assets
	  	 	10	  
		 	 2.17
	  	 Financial Statements
	  	 	10	  
		 	 2.18
	  	 Employee Benefit Plans
	  	 	10	  
		 	 2.19
	  	 Tax Returns, Payments and Elections
	  	 	11	  
		 	 2.20
	  	 Corporate Records
	  	 	11	  
		 	 2.21
	  	 Proprietary Information and Inventions Agreements
	  	 	11	  
		 	 2.22
	  	 Qualified Small Business Stock
	  	 	11	  
		 	 2.23
	  	 Foreign Corrupt Practices Act
	  	 	11	  
		 	 2.24
	  	 Government Contracts
	  	 	12	  
		 	 2.25
	  	 Insurance
	  	 	12	  
		 	 2.26
	  	 Section 83(b) Elections
	  	 	12	  
			
	 3.
	 	 Representations of the Purchasers
	  	 	12	  
				
		 	 3.1
	  	 Authorization
	  	 	12	  
		 	 3.2
	  	 Purchase Entirely for Own Account
	  	 	12	  
		 	 3.3
	  	 Disclosure of Information
	  	 	13	  
		 	 3.4
	  	 Investment Experience
	  	 	13	  
		 	 3.5
	  	 Accredited Investor
	  	 	13	  

  
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 TABLE OF CONTENTS 

(Continued) 
  

									
	 	 	 	  	 	  	Page	 
		 	 3.6
	  	 Restricted Securities
	  	 	13	  
		 	 3.7
	  	 No Public Market
	  	 	13	  
		 	 3.8
	  	 Legends
	  	 	13	  
			
	 4.
	 	 Conditions to the Obligations of the Purchasers
	  	 	14	  
				
		 	 4.1
	  	 Representations and Warranties
	  	 	14	  
		 	 4.2
	  	 Performance
	  	 	14	  
		 	 4.3
	  	 Opinion of Counsel
	  	 	14	  
		 	 4.4
	  	 Securities Law Approvals
	  	 	14	  
		 	 4.5
	  	 Voting Agreement
	  	 	14	  
		 	 4.6
	  	 Right of First Refusal and Co-Sale Agreement
	  	 	14	  
		 	 4.7
	  	 Certificates and Documents
	  	 	14	  
		 	 4.8
	  	 Management Rights Letter
	  	 	15	  
		 	 4.9
	  	 Compliance Certificate
	  	 	15	  
		 	 4.10
	  	 Board of Directors
	  	 	15	  
		 	 4.11
	  	 Indemnification Agreements
	  	 	15	  
		 	 4.12
	  	 Absence of Litigation
	  	 	15	  
		 	 4.13
	  	 Other Matters
	  	 	15	  
			
	 5.
	 	 Conditions to Obligations of the Company
	  	 	16	  
				
		 	 5.1
	  	 Representations and Warranties
	  	 	16	  
		 	 5.2
	  	 Payment of Purchase Price
	  	 	16	  
		 	 5.3
	  	 Absence of Litigation
	  	 	16	  
		 	 5.4
	  	 Other Matters
	  	 	16	  
			
	 6.
	 	 Covenants of the Company
	  	 	16	  
				
		 	 6.1
	  	 Financial Statements
	  	 	16	  
		 	 6.2
	  	 Operating Plan; Other Reporting
	  	 	17	  
		 	 6.3
	  	 Inspection
	  	 	17	  
		 	 6.4
	  	 Employee Agreements
	  	 	17	  
		 	 6.5
	  	 Employee Stock Options
	  	 	17	  
		 	 6.6
	  	 Reservation of Conversion Stock
	  	 	18	  
		 	 6.7
	  	 Board Meetings
	  	 	18	  
		 	 6.8
	  	 Qualified Small Business Stock
	  	 	18	  
			
	 7.
	 	 Participation Rights
	  	 	18	  
				
		 	 7.1
	  	 Definitions
	  	 	18	  
		 	 7.2
	  	 Participation Right
	  	 	19	  
		 	 7.3
	  	 Exercise of Right
	  	 	19	  
		 	 7.4
	  	 Overallotment
	  	 	19	  
		 	 7.5
	  	 Closing
	  	 	20	  

  
 -ii- 

 TABLE OF CONTENTS 

(Continued) 
  

									
	 	 	 	  	 	  	Page	 
		 	 7.6
	  	 Failure to Exercise Right
	  	 	20	  
		 	 7.7
	  	 Transfer of Participation Right
	  	 	20	  
			
	 8.
	 	 Registration Rights
	  	 	21	  
				
		 	 8.1
	  	 Definitions
	  	 	21	  
		 	 8.2
	  	 Demand Registration
	  	 	23	  
		 	 8.3
	  	 “Piggy-Back” Registration
	  	 	24	  
		 	 8.4
	  	 Form S-3 Registration
	  	 	25	  
		 	 8.5
	  	 Obligations of the Company
	  	 	26	  
		 	 8.6
	  	 Furnish Information
	  	 	28	  
		 	 8.7
	  	 Expenses of Demand and S-3 Registrations
	  	 	28	  
		 	 8.8
	  	 Expenses of “Piggy-Back” Registration
	  	 	28	  
		 	 8.9
	  	 Delay of Registration
	  	 	28	  
		 	 8.10
	  	 Indemnification
	  	 	29	  
		 	 8.11
	  	 Reports Under the 1934 Act
	  	 	31	  
		 	 8.12
	  	 “Market Stand-Off” Agreement
	  	 	31	  
		 	 8.13
	  	 Termination of Registration Rights
	  	 	32	  
			
	 9.
	 	 Transfers and Assignment
	  	 	32	  
				
		 	 9.1
	  	 Assignment of Certain Rights
	  	 	32	  
		 	 9.2
	  	 Subsequent Transfers
	  	 	33	  
			
	 10.
	 	 Confidentiality
	  	 	33	  
				
		 	 10.1
	  	 Confidential Information
	  	 	33	  
		 	 10.2
	  	 Foundation
	  	 	33	  
			
	 11.
	 	 Miscellaneous
	  	 	34	  
				
		 	 11.1
	  	 Survival of Representations and Warranties
	  	 	34	  
		 	 11.2
	  	 Termination of Certain Provisions
	  	 	34	  
		 	 11.3
	  	 Expenses
	  	 	34	  
		 	 11.4
	  	 Successors and Assigns
	  	 	34	  
		 	 11.5
	  	 Governing Law
	  	 	35	  
		 	 11.6
	  	 Counterparts
	  	 	35	  
		 	 11.7
	  	 Construction
	  	 	35	  
		 	 11.8
	  	 Notices
	  	 	35	  
		 	 11.9
	  	 Brokers
	  	 	36	  
		 	 11.10
	  	 Amendments and Waivers
	  	 	36	  
		 	 11.11
	  	 Severability
	  	 	36	  
		 	 11.12
	  	 Aggregation of Stock
	  	 	36	  
		 	 11.13
	  	 Entire Agreement
	  	 	37	  
		 	 11.14
	  	 Delays or Omissions
	  	 	37	  

  
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 EXHIBITS 
  

			
	Exhibit A	  	Form of Restated Certificate
		
	Exhibit B	  	Form of Fourth Amended and Restated Voting Agreement, as amended by Amendment No. 1 thereto
		
	Exhibit C	  	Form of Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement, as amended by Amendment No. 1 thereto
		
	Exhibit D	  	Form of Proprietary Information and Inventions Agreement
		
	Exhibit E	  	Form of Legal Opinion
		
	Exhibit F	  	Form of Indemnification Agreement
	
	SCHEDULE
		
	Schedule 1	  	Schedule of Purchasers
	
	Disclosure Schedule

  
 -iv- 

 AMENDED AND RESTATED 

SERIES B CONVERTIBLE 

PREFERRED STOCK PURCHASE AGREEMENT 

This Amended and Restated Series B Convertible Preferred Stock Purchase Agreement dated as of September 12, 2014 (this
“Agreement”) is made by and among (i) Visterra, Inc., a Delaware corporation (the “Company”), (ii) the persons and entities listed on Schedule 1 hereto (each individually, a
“Purchaser” and collectively, the “Purchasers”), (iii) solely for the purposes of Sections 6 through 11 of this Agreement, the “Preferred Holders” (as defined in
Section 8.1 below) who are not Purchasers, and, (iv) solely for the purposes of Sections 8 through 11 of this Agreement, the “Founder Holders” (as defined in Section 8.1 below). 

WHEREAS, on May 15, 2014, the Company, certain of the Purchasers (the “Initial Purchasers”) and certain of the Preferred
Holders and Founder Holders entered into a Series B Convertible Preferred Stock Purchase Agreement (the “Original Agreement”); 

WHEREAS, on May 15, 2014, the Company and the Initial Purchasers effected the First Closing in the manner described in
Section 1.2(a) below; 
 WHEREAS, the parties desire to amend the Original Agreement to, among other things, permit the sale of
additional shares of Series B Preferred Stock at the Second Closing to additional Purchasers (the “Additional Purchasers”), to provide for the issuance to each Purchaser of .25 of a share of Common Stock, $0.0001 par value per
share (“Common Stock”) (rounded down to the nearest whole share), for each share of Series B Convertible Preferred Stock, $0.01 par value per share (the “Series B Preferred Stock”), purchased by such
Purchaser at the Second Closing, to revise the Schedule of Purchasers for the First Closing to reflect the Common Stock being issued in respect of the shares sold in the First Closing, to revise the Schedule of Purchasers for the Second Closing to
include the Additional Purchasers and to reflect the shares of Common Stock being issued in respect of the shares being sold in the Second Closing and to amend the voting thresholds required to amend certain sections of this Agreement; 

WHEREAS, Section 11.10 of the Original Agreement provides that the Purchase Agreement may be amended with the written consent of
the Company and the holders of more than sixty percent (60%) of the outstanding shares of Series B Preferred Stock sold pursuant to the Original Agreement; and 

WHEREAS, as consideration for the willingness of the Initial Purchasers to consent to the amendment and restatement of the Original Agreement,
the Company has agreed to issue to each Initial Purchaser .25 of a share of Common Stock (rounded down to the nearest whole share) for each share of Series B Preferred Stock purchased by such Purchaser at the First Closing; 

NOW, THEREFORE, in consideration of the mutual covenants contained herein and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the Company, the Additional Purchasers and the undersigned holders of at least sixty percent (60%) of 

 
the outstanding shares of Series B Preferred Stock sold pursuant to the Original Agreement hereby agree as follows: 

1. Authorization; Sale and Issuance of Series B Shares and Common Shares 

1.1 Authorization 
 (a)
The Company shall adopt and file with the Secretary of State of the State of Delaware on or before the Second Closing an Amended and Restated Certificate of Incorporation (the “Restated Certificate”) in the form of
Exhibit A attached to this Agreement, which shall set forth the terms of the Series B Preferred Stock to be purchased under this Agreement. 

(b) Prior to the First Closing (as defined below), the Company duly authorized (i) the sale and issuance, pursuant to the terms of this
Agreement, of up to an aggregate of 12,000,000 shares of Series B Preferred Stock to be sold at the First Closing and (ii) the reservation of shares of Common Stock for issuance upon conversion of the Series B Shares (as defined
below) to be sold at the First Closing. The Company has, or prior to the Second Closing (as defined below) will have, duly authorized (x) the sale and issuance, pursuant to the terms of this Agreement of up to an aggregate of 12,000,000
additional shares of Series B Preferred Stock to be sold and issued in the Second Closing, (y) the sale and issuance pursuant to the terms of this Agreement of up to 6,000,000 shares of Common Stock to be sold and issued in the Second
Closing and (z) the reservation of shares of Common Stock for issuance upon conversion of the shares of Series B Preferred Stock to be sold at the Second Closing. The shares of Series B Preferred Stock sold under this Agreement are
referred to herein as the “Series B Shares.” 
 1.2 Sale and Issuance of Shares 

(a) The initial purchase and sale of shares under this Agreement (the “First Closing”) took place remotely via the exchange
of documents and signatures on May 15, 2014. At the First Closing, the Company sold and issued to each of the Purchasers purchasing Series B Shares in the First Closing, and each of such Purchasers purchased, for the purchase price of
$1.25 per share (the “Purchase Price”), the number of Series B Shares set forth opposite such Purchaser’s name on Schedule 1 under the heading “Number of First Closing Series B Shares.” 

(b) The second purchase and sale of shares under this Agreement (the “Second Closing” and, together with the First Closing,
the “Closings”) shall take place at 10:00 am, Boston time, on September 12, 2014, remotely via the exchange of documents, or at the offices of Wilmer Cutler Pickering Hale and Dorr LLP, located at 60 State Street, Boston,
Massachusetts 02109 (or at such other place as the Company and the Purchasers purchasing at least a majority of the Series B Shares to be sold at the Second Closing mutually agree on, orally or in writing). At the Second Closing, subject to the
terms and conditions of this Agreement, (i) the Company will issue and sell to each Purchaser purchasing shares in the Second Closing, at the Purchase Price, the number of Series B Shares set forth opposite such Purchaser’s name on
Schedule 1 under the heading “Number of Second Closing Series B Shares”; (ii) the Company will issue and sell to such Purchasers, as an additional inducement to purchase Series B Shares and in consideration of
the 

  
 -2- 

 
aggregate purchase price paid for the Series B Shares purchased by such Purchasers, .25 of a share of Common Stock for each Series B Share purchased by such Purchaser at the Second Closing
(with any fractional number rounded down to the nearest whole share); and (iii) the Company will issue and sell to each Purchaser, in consideration of the aggregate purchase price paid by such Purchaser for the shares of Series B Stock
purchased at the First Closing and in consideration of each such Purchaser agreeing to amend and restate the Original Agreement on the terms hereof, .25 of a share of Common Stock for each Series B Share purchased by such Purchaser at the First
Closing (with any fractional number rounded down to the nearest whole share). The number of shares of Common Stock to be issued to each such Purchaser is set forth opposite such Purchaser’s respective name on Schedule 1 under the
heading “Number of Common Shares.” The shares of Common Stock issued pursuant to this Section 1.2(b) are referred to herein as the “Common Shares” and, together with the Series B Shares, as the
“Shares.” 
 (c) At each Closing, the Company shall deliver to each Purchaser a certificate representing the number of
Series B Shares being purchased by and issued to such Purchaser at such Closing, and at the Second Closing, the Company shall also deliver to each Purchaser a certificate representing the number of Common Shares being purchased by and issued to
such Purchaser at the Second Closing, in each case against payment of the Purchase Price therefor by check payable to the Company or by wire transfer to a bank account designated by the Company. Any Purchaser who did not purchase Series B
Shares in the First Closing shall become a party to the Financing Agreements (as defined below) by executing and delivering a counterpart signature page to such agreements substantially in the form attached to this Agreement. 

1.3 Use of Proceeds. In accordance with the directions of the Company’s board of directors (the “Board”), as
it shall be constituted in accordance with the Voting Agreement (as defined below), the Company will use the proceeds from the sale of the Shares for general corporate purposes, including, but not limited to, funding the Company’s VIS410 phase
2 proof of concept studies for influenza treatment and prevention, and advancing the Company’s dengue antibody program. 
 2.
Representations of the Company. The Company hereby represents and warrants to each Purchaser that, except as set forth in the Disclosure Schedule attached to the Original Agreement with respect to the First Closing or attached hereto
with respect to the Second Closing, the following representations and warranties are true and complete as of such Closing, as applicable, except with respect to any representation or warranty that is expressly made as of a different date, in which
case such representation or warranty shall be true and correct as of such date. The Disclosure Schedule is arranged in sections corresponding to the numbered and lettered sections and subsections contained in this Section 2, and the
disclosures in any section or subsection of the Disclosure Schedule shall qualify other sections and subsections in this Section 2 to the extent it is readily apparent from a reading of the disclosure that such disclosure is applicable
to such other sections and subsections. 
 2.1 Organization; Good Standing and Qualification. The Company is a corporation duly
organized, validly existing, and in good standing under the laws of the State of 

  
 -3- 

 
Delaware and has all requisite corporate power and authority to own its property, to carry on its business as now conducted and as proposed to be conducted, to execute, deliver and perform its
obligations under this Agreement, the Fourth Amended and Restated Voting Agreement, as amended by Amendment No. 1 thereto, in the form of Exhibit B hereto (the “Voting Agreement”), and the Fourth Amended and
Restated Right of First Refusal and Co-Sale Agreement, as amended by Amendment No. 1 thereto, in the form of Exhibit C hereto (the “Right of First Refusal and Co-Sale Agreement” and, collectively with the Voting
Agreement and this Agreement, the “Financing Agreements”) and to consummate the transactions contemplated hereby and thereby. The Company is duly qualified to transact business and is in good standing in the Commonwealth of
Massachusetts and in each other foreign jurisdiction in which the failure to so qualify would have a material adverse effect on its business or properties. 

2.2 Authorization. The Financing Agreements constitute valid and legally binding obligations of the Company, enforceable in
accordance with their terms, subject to and limited by (i) applicable bankruptcy, insolvency, reorganization, moratorium, and other laws generally applicable to creditors’ rights, (ii) judicial discretion in the availability of
equitable relief, and (iii) federal and state securities laws to the extent applicable to the indemnification provision set forth in Section 8 (the “Bankruptcy and Equitable Remedies Exception”). The execution,
delivery and performance of the Financing Agreements and the performance of all obligations of the Company thereunder have been duly authorized by all necessary corporate, stockholder or other action of the Company. Prior to any Closing, the Company
shall take all necessary corporate action to authorize the issuance, sale and delivery of the Shares to be sold and delivered at such Closing, in accordance with this Agreement and the issuance and delivery of the shares of Common Stock upon
conversion of the Series B Shares to be sold at such Closing. 
 2.3 Valid Issuance of Stock.

(a) The Shares, when issued, sold, and delivered in accordance with this Agreement for the consideration set forth on Schedule 1,
and the shares of Common Stock issuable upon conversion of the Series B Shares, when issued upon such conversion, will be duly and validly issued, fully paid, and nonassessable and, based in part upon the representations of the Purchasers in
this Agreement, will (i) be issued in compliance with all applicable federal and state securities laws, subject to the securities law filings described in Section 2.4 below and (ii) be free and clear of all mortgages, liens,
charges, security interests, adverse claims, pledges, encumbrances and demands whatsoever (other than those created by the Purchasers); provided, however, that such shares may be subject to restrictions on transfer imposed or created
under the Financing Agreements or by applicable law. 
 (b) The outstanding shares of Seed Preferred Stock (as defined below),
Series A Preferred Stock (as defined below) and Common Stock were all duly and validly authorized and issued, fully paid, and nonassessable, and were issued in compliance with all applicable federal and state securities laws. 

(c) No “bad actor” disqualifying event (a “Disqualification Event”) described in Rule 506(d)(1)(i)-(viii) of
the Securities Act of 1993, as amended (the “Securities  

  
 -4- 

 
Act”), is applicable to the Company or, to the Company’s knowledge, any Company Covered Person (as defined below), except for a Disqualification Event as to which Rule
506(d)(2)(ii)-(iv) or (d)(3) is applicable. “Company Covered Person” means, with respect to the Company as an “issuer” for purposes of Rule 506, any Person listed in the first paragraph of Rule 506(d)(1). 

2.4 Governmental Consents. The Company is not required to obtain the consent, approval, order, or authorization of, or complete
any registration, qualification, designation, declaration, or filing with, any federal, state, local, or provincial governmental authority in connection with the execution, delivery and performance of the Financing Agreements and the consummation of
the transactions contemplated thereby, except for certain federal and state securities law filings that are permitted or required to be filed following any Closing. 

2.5 Capitalization. The authorized capital of the Company consists, as of the date hereof (immediately prior to the Second
Closing), of the following: 
 (a) Preferred Stock. 63,378,633 shares of preferred stock, $0.01 par value per share
(“Preferred Stock”), of which (i) 6,611,561 shares have been designated Seed Convertible Preferred Stock (“Seed Preferred Stock”), 6,091,426 of which are issued and outstanding, (ii) 32,447,072 shares have
been designated Series A Convertible Preferred Stock (“Series A Preferred Stock”), all of which are issued and outstanding, and (iii) 24,320,000 shares have been designated Series B Preferred Stock, 12,000,000 of
which are issued and outstanding. The rights, privileges and preferences of the Seed Preferred Stock, Series A Preferred Stock and Series B Preferred Stock are as stated in the Restated Certificate. 

(b) Common Stock. 98,000,000 shares of Common Stock, of which, as of the date hereof, 9,449,377 shares are issued and outstanding.

 (c) The outstanding shares of capital stock of the Company (i) have been duly authorized and validly issued in compliance with
applicable laws, and are fully paid and nonassessable, and (ii) with respect to the outstanding shares of Common Stock held by the holders of at least one percent (1%) or more of the Company’s issued and outstanding securities on an
as converted fully diluted basis, are subject to a right of first refusal in favor of the Company upon transfer, subject to standard exceptions. All outstanding securities of the Company held by the holders of at least one percent (1%) or more
of the Company’s issued and outstanding securities on an as converted fully diluted basis, including, without limitation, all shares of capital stock of the Company issuable upon conversion or exercise of all convertible or exercisable
securities, are subject to a one hundred eighty (180) day “market stand-off” restriction upon an initial public offering of the Company’s securities pursuant to a registration statement filed with the Securities and Exchange
Commission. 
 (d) The Company has reserved: 

(A) the Common Shares for issuance pursuant to this Agreement; 

  
 -5- 

 (B) 24,320,000 shares of Common Stock for issuance upon the conversion of the Series B Shares;

 (C) 63,378,633 shares of Common Stock (as may be adjusted in accordance with the provisions of the Amended and Restated Certificate) for
issuance upon conversion of the Preferred Stock; and 
 (D) 11,792,500 shares of Common Stock authorized for issuance to employees,
consultants and directors pursuant to its 2008 Stock Incentive Plan, as amended, of which options to purchase 9,061,703 shares have been granted and are currently outstanding and 1,789,981 shares of Common Stock remain available for issuance to
employees, consultants and directors pursuant to the 2008 Stock Incentive Plan, as amended. 
 (e) Warrants. 87,500 shares of Seed
Preferred Stock, 320,000 shares of Series B Preferred Stock and 2,960,280 shares of Common Stock of the Company have been reserved for issuance upon exercise of warrants issued by the Company. 

(f) Rights To Acquire Stock. Except as set forth on Section 2.5(f) of the Disclosure Schedule and in the Financing
Agreements, there are no outstanding options, warrants, rights (including conversion rights, preemptive rights or rights of first refusal) or agreements for the purchase or acquisition from the Company of any shares of its capital stock. 

(g) Securityholder Lists and Agreements. Set forth in Section 2.5(g)(i) of the Disclosure Schedule is a true and complete
list of all securityholders of the Company, showing the number of shares of Series B Preferred Stock, Series A Preferred Stock, Seed Preferred Stock, Common Stock or other securities of the Company held by each such securityholder as of
the date of this Agreement. Except as disclosed in Section 2.5(g)(ii) of the Disclosure Schedule and except as set forth in the Financing Agreements, there are no agreements, written or oral, between the Company and any holder of its
capital stock, or, to the best knowledge of the Company, between or among any holders of its capital stock, relating to the acquisition (including the redemption by the Company), disposition, registration or voting of the capital stock of the
Company or rights for stockholders information about the Company. Except as set forth in Section 2.5(g)(iii) of the Disclosure Schedule and except as set forth in the Financing Agreements, the Shares sold hereunder and the shares of
Common Stock issuable upon conversion of the Series B Shares are not subject to any preemptive rights or rights of first refusal, and there are no other agreements that provide any person with the right to purchase any shares of capital stock
of the Company, regardless of whether such shares are currently outstanding. 
 (h) Vesting Schedule. All options granted vest as
follows: (i) twenty-five percent (25%) of the shares vest one (1) year following the vesting commencement date, with the remaining seventy-five percent (75%) vesting in equal installments over the next three (3) years or
(ii) one hundred percent (100%) of the shares vest in equal monthly installments over the four years following the grant date. No stock plan, stock purchase, stock option or other agreement or understanding between the Company and any
holder of any equity securities or rights to purchase equity securities provides for acceleration or other changes in the vesting provisions or other terms 

  
 -6- 

 
of such agreement or understanding as the result of (i) termination of employment (whether actual or constructive); (ii) any merger, consolidated sale of stock or assets, change in
control or any other transaction(s) by the Company; or (iii) the occurrence of any other event or combination of events. 
 (i)
Compliance with Securities Laws. All issued and outstanding shares of the Company’s Common Stock and Preferred Stock (i) have been duly authorized and validly issued and are fully paid and nonassessable, and (ii) were issued in
compliance with all applicable state and federal laws concerning the issuance of securities. 
 2.6 Subsidiaries. The Company
does not own or control, directly or indirectly, any interest in any other corporation, association, or other business entity. The Company is not a participant in any joint venture, partnership or similar arrangement. 

2.7 Environmental and Safety Laws. To the best of its knowledge, the Company is not in violation of any applicable statute, law,
or regulation relating to the environment or occupational health and safety, and to the best of its knowledge, no material expenditures are or will be required by the Company in order to comply with any such existing statute, law, or regulation.

 2.8 Litigation. There is no action, suit, proceeding, or investigation currently pending or, to the best knowledge of the
Company, currently threatened against the Company or any of its officers or directors that (i) challenges the validity of the Financing Agreements or the authority of the Company to execute the Financing Agreements or to consummate the
transactions contemplated therein, (ii) might result in any material adverse change in the assets, condition, prospects, or affairs, of the Company, financially or otherwise, or (iii) might result in any material change in the current
equity ownership of the Company, nor is the Company aware of any basis for the foregoing. There is no action, suit, proceeding, or investigation by the Company currently pending or that the Company intends to initiate. 

2.9 Intellectual Property. Except as set forth in Section 2.9 of the Disclosure Schedule, the Company has sufficient
rights in or ownership of all licenses, patents, patent rights, trademarks, trademark rights, service marks, service mark rights, trade names, trade name rights, copyrights, trade secrets, information, proprietary rights and processes necessary for
its business as now being conducted and as currently proposed to be conducted without, to its knowledge, any material conflict with or infringement of the intellectual property rights of others. Except for the Exclusive Patent License Agreement
entered into by the Company and MIT on April 28, 2008, as it may be amended from time to time (the “2008 Patent License Agreement”), and that certain Exclusive Patent License Agreement entered into by the Corporation and MIT on
November 15, 2013, as it may be amended from time to time (together with the 2008 Patent License Agreement, the “Patent License Agreements”) and as set forth in Section 2.9 of the Disclosure Schedule, the Company is
not bound by or a party to any material options, licenses, or agreements with respect to the patents, trademarks, service marks, trade names, copyrights, trade secrets, licenses, information, proprietary rights, or processes of any other person

  
 -7- 

 
or entity. The Company has not received any communications alleging that the Company has infringed or misappropriated or, by conducting its business as proposed, would infringe, violate or
misappropriate any of the patents, trademarks, service marks, trade names, copyrights, trade secrets, or other proprietary rights of any other person or entity. The Company has no knowledge that any of its officers, employees or consultants is
obligated under any contract (including licenses, covenants, or commitments of any nature) or other agreement, or is subject to any judgment, decree, or order of any court or administrative agency, that would interfere with his or her ability to
perform his or her intended duties for the Company or that would conflict with the intended business of the Company, the execution and delivery of the Financing Agreements, the conduct of the intended duties of officers, employees and consultants of
the Company, and to the best knowledge of the Company, the conduct of the business of the Company as currently conducted and as proposed to be conducted, will not conflict with or result in a breach of the terms, conditions, or provisions of, or
constitute a default under, any contract, covenant, or instrument which legally binds any of such officers, employees or consultants. The Company does not believe it is or will be necessary to utilize any inventions made by its current officers,
employees or consultants prior to their association with the Company, except for inventions covered by the Patent License Agreements. 

2.10 Compliance with Other Instruments. The Company is not in violation or default of (i) any provision of the Restated
Certificate or its By-Laws, (ii) any legally binding instrument, judgment, order, writ, decree, or contract, other than any such violations or defaults that do not and will not, individually or in the aggregate, have a material adverse effect
on the Company or (iii) any material provision of federal or state statute, rule, or regulation applicable to the Company. The execution, delivery, and performance of the Financing Agreements and the consummation of the transactions
contemplated therein will not (a) conflict with, nor result in any violation of or default under any such instrument, judgment, order, writ, decree, contract, or provision or (b) give rise to any event that results in the creation of any
lien, charge, or encumbrance upon any assets of the Company or the suspension, revocation, impairment, forfeiture, or nonrenewal of any material permit, license, authorization, or approval that applies to the Company, its business or operations, or
any of its assets or properties. The Company has not performed any act or failed to perform any act, the occurrence of which would result in the Company’s loss of any right granted under any license or other agreement set forth in the
Disclosure Schedule, except where the loss of such right would not, individually or in the aggregate, be reasonably likely to have a material adverse effect on the Company or its assets, liabilities, financial conditions, prospects or operations.

 2.11 Contracts and Commitments.

(a) Section 2.11(a) of the Disclosure Schedule contains a list of all agreements, contracts, obligations, or commitments, of any
nature to which the Company is a party or by which it or any of its properties are bound, other than the Financing Agreements, that are material to the conduct and operations of its business and properties, including any such contracts that are
employment contracts; stock redemption or purchase agreements; loan agreements, security agreements and guaranties; licenses, distributor or sales representative agreements; agreements with officers, directors, employees or shareholders of the
Company or persons or organizations related to or affiliated with any such persons; leases; agreements relating to product development; or pension, profit-sharing, retirement or stock option plans (collectively, the “Material
Contracts”). Each Material Contract constitutes a valid and legally binding obligation of the Company, enforceable in accordance with its respective terms, and is in full force and effect. The Company is not in material

  
 -8- 

 
default under any Material Contract and there is no state of facts which upon notice or lapse of time or both would constitute such a default. To the best knowledge of the Company, no other party
to a Material Contract is in default thereunder and to the best knowledge of the Company, there is no state of facts which upon notice or lapse of time or both would constitute such a default. The performance of each Material Contract by the Company
will not violate any other agreement, judgment, order, writ or decree binding upon the Company or any material provision of any federal or state statute, rule or regulation applicable to the Company. To the best of the Company’s knowledge, the
performance of each Material Contract by each other party thereto will not violate any other agreement, judgment, order, writ or decree binding upon such other party or any material provision of any federal or state statute, rule or regulation
applicable to such other party. The Company is not a party to any contract or arrangement that is reasonably likely to have a material adverse effect on the business, properties, or prospects of the Company. 

(b) To the best knowledge of the Company, no employee of the Company is in default under any outstanding contract, obligation, or commitment
of such employee with any prior employer. Neither the Company nor, to the best knowledge of the Company, any of its employees, officers, directors or consultants is a party to any contract or agreement, oral or written, that prohibits them from
freely competing or engaging in the business of the Company. 
 (c) A true and complete copy of each Material Contract has been made
available to counsel to the Purchasers and the Company. 
 (d) Except as set forth in the Financing Agreements, the Company is presently
not under any obligation, and has not granted any rights, to register under the Securities Act any of the Company’s presently outstanding securities or any of its securities that may hereafter be issued. To the Company’s knowledge, except
as contemplated in the Voting Agreement, no stockholder of the Company has entered into any agreement with respect to the voting of equity securities of the Company. 

2.12 Related-Party Transactions. No employee, officer, director or consultant of the Company or member of his or her immediate
family is indebted to the Company, nor is the Company indebted (or committed to make loans or extend or guarantee credit) to any of them. To the best knowledge of the Company, none of such persons has any direct or indirect ownership interest in any
firm or corporation with which the Company is affiliated or with which the Company has a business relationship, or any firm or corporation that competes with the Company, except that employees, officers, directors or consultants of the Company and
members of their immediate families may own stock in publicly traded companies that may compete with the Company where such interest does not exceed one percent (1%) of the outstanding voting stock of any such publicly traded company. No
officer or director of the Company or member of the immediate family of any officer or director of the Company is directly or indirectly interested in any Material Contract. Section 2.12 of the Disclosure Schedule sets forth, as of the
date hereof (or the date of the relevant Closing), the cash, equity and other compensation paid or promised to be paid to each officer of the Company. No employee of the Company has been granted the right to continued employment by the Company or to
any material compensation following termination of employment with the Company. 

  
 -9- 

 2.13 Permits. The Company has obtained all franchises, permits, licenses, and any
similar authority necessary for the conduct of its current operations, the lack of which could materially and adversely affect the business, properties, or financial condition of the Company. The Company is not in violation in any material respect
of any of such franchises, permits, licenses, or other similar authority. 
 2.14 Information Supplied to Purchasers. Neither
this Agreement, the Schedules and Exhibits hereto, the Voting Agreement, the Right of First Refusal and Co-Sale Agreement, nor any certificate, projection or statement or any written information provided to the Purchasers by or on behalf of the
Company, when read together, contains any untrue statement of a material fact or omits to state a material fact necessary in order to make the statements contained herein or therein not misleading. There is no material fact relating to the business,
prospects, operations, affairs, or conditions of the Company which adversely affects the same which has not been set forth in this Agreement or in the Schedules or Exhibits. The Company has fully provided each Purchaser with all the information that
such Purchaser has requested for deciding whether to purchase the Shares. 
 2.15 Corporate Documents. The Restated Certificate
and By-Laws of the Company are in the form previously provided to the Purchasers. 
 2.16 Title to Property and Assets. The
Company has good title to, or a valid leasehold interest in, all of its material property and assets and none of such property or assets is subject to any mortgages, liens, loans or encumbrances, except (i) for statutory liens for the payment
of current taxes that are not yet delinquent and (ii) such encumbrances and liens which arise in the ordinary course of business and which, either singly or in the aggregate, do not materially impair the Company’s ownership or use of such
property or assets. 
 2.17 Financial Statements. The Company has delivered to the Purchasers (a) the unaudited balance
sheet of the Company at December 31, 2013 and the related unaudited statements of operations and cash flows for the fiscal year then ended and (b) the unaudited balance sheet of the Company at and for the six-month period ended
June 30, 2014 (together, the “Financial Statements”). The Financial Statements are correct and complete in all material respects as of the dates indicated therein, have been prepared in accordance with generally accepted
accounting principles applied on a consistent basis through the periods indicated therein, and fairly and accurately present the financial position of the Company as of the dates indicated therein, except that the unaudited Financial Statements may
not contain all footnotes required by generally accepted accounting principles (“GAAP”). The Financial Statements have been prepared from the books and records of the Company, which books and records accurately and fairly reflect
the financial position of the Company 
 2.18 Employee Benefit Plans. Section 2.18 of the Disclosure Schedule lists
all employee benefit plans (as defined in Section 3(3) of the Employee Retirement Income Security Act of 1974, as amended (“ERISA”) maintained by the Company. Each of such employee benefit plans complies in all material
respects with (a) all applicable requirements of ERISA and (b) all applicable requirements of the Internal Revenue Code of 1986, as amended (the “Code”). 

  
 -10- 

 2.19 Tax Returns, Payments and Elections. The Company has duly and timely filed all
tax returns and tax reports (including information returns and reports) as required by law. Such returns and reports are true and correct in all material respects, including the amount shown as due from the Company. The Company has paid all taxes
and other assessments due to the Internal Revenue Service or any state taxing authority. The Company’s tax returns have not, been audited by the United States Internal Revenue Service or by any state taxing authority and, to the Company’s
knowledge, no such audit has been threatened by any such federal or state authority. 
 2.20 Corporate Records. The minute books
of the Company provided to the Purchasers contain complete records of all meetings and other corporate actions of the Board and the Company’s stockholders since the time of incorporation and reflect all transactions referred to in such minutes
and corporate actions accurately in all material respects. 
 2.21 Proprietary Information and Inventions Agreements. Each
current and former employee, consultant and officer of the Company has executed a Proprietary Information and Inventions Agreement in substantially the form attached hereto as Exhibit D, or an agreement containing substantially similar
terms, and, except as set forth in Section 2.21 of the Disclosure Schedule, has not excluded works or inventions made prior to his or her employment with the Company from his or her assignment of inventions pursuant thereto. The Company
has no knowledge that any of its current or former employees, consultants or officers are in violation of these agreements. 
 2.22
Qualified Small Business Stock. To the best of its knowledge, the Company is a “qualified small business” within the meaning of Section 1202(d) of the Code as of the date hereof (or as of the date of the relevant Closing)
and the Series B Preferred Stock should qualify as “qualified small business stock” as defined in Section 1202(c) of the Code as of the date hereof. As of the date hereof (or as of the date of the relevant Closing): (i) the
Company will be an eligible corporation as defined in Section 1202(e)(4) of the Code, (ii) the Company will not have made any purchases of its own stock during the one-year period preceding the relevant Closing having an aggregate value
exceeding 5% of the aggregate value of all of its stock as of the beginning of such period and (iii) the Company’s aggregate gross assets, as defined by Code Section 1202(d)(2), at no time between formation and through the Second
Closing have exceeded or will exceed $50 million, taking into account the assets of any corporations required to be aggregated with the Company in accordance with Code Section 1202(d)(3); provided, however, that in no event shall
the Company be liable to the Purchasers for any damages arising from any subsequently proven or identified error in the Company’s determination with respect to the applicability or interpretation of Section 1202 unless such determination
shall have been given by the Company in a manner that was either negligent or fraudulent. 
 2.23 Foreign Corrupt Practices
Act. Neither the Company nor any of the Company’s directors, officers, employees or agents have, directly or indirectly, made, offered, promised or authorized any payment or gift of any money or anything of value to or for the benefit
of any “foreign official” (as such term is defined in the U.S. Foreign Corrupt Practices Act of 1977, as amended (the “FCPA”)), foreign political party or official thereof or candidate for foreign

  
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political office for the purpose of (i) influencing any official act or decision of such official, party or candidate, (ii) inducing such official, party or candidate to use his, her or
its influence to affect any act or decision of a foreign governmental authority, or (iii) securing any improper advantage, in the case of (i), (ii) and (iii) above in order to assist the Company or any of its affiliates in obtaining
or retaining business for or with, or directing business to, any person. Neither the Company nor any of its directors, officers, employees or agents have made or authorized any bribe, rebate, payoff, influence payment, kickback or other unlawful
payment of funds or received or retained any funds in violation of any law, rule or regulation. Neither the Company, or, to the Company’s knowledge, any of its officers, directors or employees are the subject of any allegation, voluntary
disclosure, investigation, prosecution or other enforcement action related to the FCPA or any other anti-corruption law (collectively, “Enforcement Action”). 

2.24 Government Contracts. The Company has complied in all material respects with all applicable laws, regulations, and provisions
of each contract, subcontract and outstanding bid or proposal with any government or any instrumentality or agency thereof (“Government Contracts”). All technical data, computer software and computer software documentation
developed, delivered, or used under or in connection with such Government Contracts have been properly and sufficiently marked and protected so that no more than the minimum rights or licenses required under applicable laws, regulations and
Government Contract terms, if any, have been provided. 
 2.25 Insurance. The Company has in full force and effect fire and
casualty insurance policies with extended coverage, sufficient in amount (subject to reasonable deductions) to allow it to replace any of its properties that might be damaged or destroyed. 

2.26 Section 83(b) Elections. To the Company’s knowledge, all elections and notices under Section 83(b) of the Code
have been or will be timely filed by all individuals who have acquired unvested shares of the Common Stock. 
 3. Representations of the
Purchasers. Each of the Purchasers, severally and not jointly, hereby represents and warrants to the Company, as of each Closing in which the Purchaser purchases Shares, as follows: 

3.1 Authorization. The Purchaser has full power and authority to enter into and perform its obligations under the Financing
Agreements in accordance with their terms. Any Purchaser which is a corporation, limited liability company, partnership, foundation or trust represents that it has not been organized, reorganized or recapitalized specifically for the purpose of
investing in the Company. The Financing Agreements constitute valid and legally binding obligations of the Purchaser, enforceable against such Purchaser in accordance with their terms, subject to and limited by the Bankruptcy and Equitable Remedies
Exception. 
 3.2 Purchase Entirely for Own Account. This Agreement is made with each Purchaser in reliance in part upon such
Purchaser’s representation to the Company, which such Purchaser hereby confirms by execution of this Agreement, that the Shares to be received by the Purchaser and the shares of Common Stock into which the Series B Shares may be converted

  
 -12- 

 (collectively, the “Securities”) will be acquired for investment for Purchaser’s own
account, not as a nominee or agent, and not with a view to the resale or distribution of any part thereof, and that such Purchaser has no present intention of selling, granting any participation in, or otherwise distributing the same. By executing
this Agreement, Purchaser further represents that, other than normal duties under any partnership agreement under which Purchaser may have been formed, such Purchaser does not have any contract, undertaking, agreement, or arrangement with any person
to sell, transfer, or grant participation to such person or to any third person, with respect to any of the Securities. 
 3.3 Disclosure
of Information. Purchaser has received all the information that it considers necessary or appropriate for deciding whether to purchase the Shares. Purchaser further represents that it has had sufficient opportunity to ask questions and
receive answers from the Company regarding the terms and conditions of the offering of the Shares. 
 3.4 Investment
Experience. Purchaser acknowledges that it is able to fend for itself, can bear the economic risk of its investment, and has such knowledge and experience in financial or business matters that it is capable of evaluating the merits and
risks of the investment in the Securities. Purchaser also represents it has not been organized for the purpose of acquiring the Securities. 

3.5 Accredited Investor. Purchaser is an “accredited investor” within the meaning of SEC Rule 501(a) of Regulation D
promulgated under the Securities Act. 
 3.6 Restricted Securities. Purchaser understands that the Securities it is purchasing
are characterized as “restricted securities” under the federal securities laws inasmuch as they are being acquired from the Company in a transaction not involving a public offering and that under such laws and applicable regulations such
securities may be resold without registration under the Securities Act only in certain limited circumstances. In this regard, Purchaser represents that it is familiar with SEC Rule 144, as currently in effect, and understands the resale limitations
imposed thereby and by the Securities Act. 
 3.7 No Public Market. The Purchaser understands that no public market now exists
for the Securities, and that the Company has made no assurances that a public market will ever exist for the Securities. 
 3.8
Legends. The Purchaser understands that the Securities and any securities issued in respect of or exchange for the Securities may bear one or more of the following legends: 

(a) “THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AND HAVE BEEN ACQUIRED
FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH TRANSFER MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE
COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933.” 

  
 -13- 

 (b) “THE SECURITIES REPRESENTED BY THIS CERTIFICATE MAY BE TRANSFERRED ONLY IN ACCORDANCE
WITH THE TERMS OF AN AGREEMENT BETWEEN THE COMPANY AND THE STOCKHOLDER, A COPY OF WHICH IS ON FILE WITH THE SECRETARY OF THE COMPANY.” 

(c) Any legend set forth in, or required by, the other Financing Agreements. 

(d) Any legend required by the securities laws of any state to the extent such laws are applicable to the Securities represented by the
certificate so legended. 
 4. Conditions to the Obligations of the Purchasers. The obligations of the Purchasers under this
Agreement at each Closing are subject to the fulfillment, or waiver by the Purchasers, of each of the following conditions of the Company on or before such Closing: 

4.1 Representations and Warranties. The representations and warranties of the Company contained in this Agreement shall be true as
of such Closing (or such other date as specified in Section 2) with the same effect as though such representations and warranties had been made on and as of the date of such Closing (or such other date as specified in
Section 2), except as set forth in the Disclosure Schedule delivered by the Company in connection with such Closing. 
 4.2
Performance. The Company shall have performed and complied with all agreements, obligations, and conditions contained in this Agreement that are required to be performed or complied with by the Company as of such Closing. 

4.3 Opinion of Counsel. The Purchasers shall have received an opinion from WilmerHale LLP, counsel to the Company, dated as of the
date of such Closing, addressed to the Purchasers, and substantially in the form of Exhibit E hereto. 
 4.4 Securities Law
Approvals. The Company shall have received all requisite approvals, if any, of the securities authorities of each jurisdiction in which such approval is required, and such approvals shall be in full force and effect as of such Closing. 

4.5 Voting Agreement. The Company, each Purchaser (other than the Purchaser relying upon this condition to excuse such
Purchaser’s performance hereunder), and the requisite other stockholders of the Company named as parties thereto shall have executed and delivered the Voting Agreement. 

4.6 Right of First Refusal and Co-Sale Agreement. The Company, each Purchaser (other than the Purchaser relying upon this
condition to excuse such Purchaser’s performance hereunder), and the requisite other stockholders of the Company named as parties thereto shall have executed and delivered the Right of First Refusal and Co-Sale Agreement. 

4.7 Certificates and Documents. The Company shall have delivered to counsel to the Purchasers: 

 

  
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 (a) a copy of the Restated Certificate as in effect immediately prior to such Closing, certified
by the Secretary of State of the State of Delaware and certificates, as of the most recent practicable date, of the Secretary of State of the State of Delaware and the Commonwealth of Massachusetts as to the Company’s corporate good standing
and qualification to do business as a foreign corporation, respectively; and 
 (b) a certificate of the Secretary of the Company dated as
of such Closing, certifying as to (i) the incumbency of officers of the Company executing the Financing Agreements and all other documents executed and delivered in connection herewith, (ii) a copy of the By-Laws of the Company, as in
effect as of such Closing, (iii) a copy of the resolutions of the Board authorizing and approving the Company’s execution, delivery, and performance of the Financing Agreements, all matters in connection with the Financing Agreements, and
the transactions contemplated thereby and a statement to the effect that such resolutions are in full force and (iv) a copy of the resolutions of the stockholders of the Company authorizing and approving the filing of the Restated Certificate.

 4.8 Management Rights Letter. The Company shall execute and deliver a management rights letter to any Purchaser so
requesting, in form reasonably satisfactory to such Purchaser(s). 
 4.9 Compliance Certificate. The President of the Company
shall deliver to the Purchasers at such Closing a certificate certifying that the conditions specified in Sections 4.1 and 4.2 have been fulfilled. 

4.10 Board of Directors. As of the Second Closing, the authorized size of the Board of Directors shall be eight (8) members,
and the Board of Directors shall be comprised of Kevin Bitterman, Edwin Kania, Chee Wang Jin Lincoln, Brian Pereira, Alan L. Crane and Ram Sasisekharan, with two vacancies. 

4.11 Indemnification Agreements. The Company and each individual who was not a director of the Company prior to the Second Closing
but who shall become a director of the Company effective upon the Second Closing shall have executed and delivered an indemnification agreement in the form attached as Exhibit F. 

4.12 Absence of Litigation. No action, suit or proceeding shall have been instituted before any court or governmental or
regulatory body or instituted or threatened by any governmental or regulatory body, to restrain, modify or prevent the carrying out of such Closing or of the transactions contemplated hereby or by the other Financing Agreements, or to seek damages
or a discovery order in connection with such transactions, or that has or may have, in the reasonable opinion of the Purchasers, a materially adverse effect on the assets, properties, business, operations or condition (financial or otherwise) of the
Company. 
 4.13 Other Matters. All corporate and other proceedings in connection with the transactions contemplated at such
Closing by this Agreement, and all documents and instruments incident to such transactions, shall be reasonably satisfactory in substance and form to the 

  
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Purchasers, and the Purchasers shall have received all such counterpart originals or certified or other copies of such documents as they may reasonably request. 

5. Conditions to Obligations of the Company. The obligations of the Company under this Agreement are subject to the fulfillment,
or waiver by the Company, of each of the following conditions of the Purchasers purchasing shares at any Closing, on or before such Closing: 

5.1 Representations and Warranties. The representations and warranties of each Purchaser contained in this Agreement shall be true
as of such Closing with the same effect as though such representations and warranties had been made on and as of the date of such Closing. 

5.2 Payment of Purchase Price. Each Purchaser shall have delivered the purchase price in the amount specified with respect to such
Purchaser in Schedule 1 for all Shares purchased by such Purchaser at such Closing. 
 5.3 Absence of Litigation. No
action, suit or proceeding shall have been instituted before any court or governmental or regulatory body or instituted or threatened by any governmental or regulatory body, to restrain, modify or prevent the carrying out of such Closing or of the
transactions contemplated hereby or by the other Financing Agreements, or to seek damages or a discovery order in connection with such transactions, or that has or may have, in the reasonable opinion of the Company, a materially adverse effect on
the assets, properties, business, operations or condition (financial or otherwise) of the Company. 
 5.4 Other Matters. All
corporate and other proceedings in connection with the transactions contemplated at the applicable Closing by this Agreement, and all documents and instruments incident to such transactions, shall be reasonably satisfactory in substance and form to
the Company and its counsel. 
 6. Covenants of the Company. The Company covenants and agrees that so long as twenty percent
(20%) of the shares of Preferred Stock outstanding as of the date hereof (after giving effect to the transactions contemplated to occur at the Second Closing), or shares of Common Stock issued upon conversion thereof, remain outstanding, it
will perform and observe the following covenants and provisions: 
 6.1 Financial Statements. The Company will maintain books of
account in accordance with GAAP applied on a consistent basis, keep full and complete financial records, and furnish the following reports to each holder of at least 500,000 shares of Preferred Stock (each, a “Preferred Investor,”
and together, the “Preferred Investors”): 
 (a) beginning with the financial statements for the fiscal year ending
December 31, 2014, as soon as practicable, but in any event within one hundred eighty (180) days after the end of the applicable fiscal year, an income statement for such fiscal year, a balance sheet of the Company, a statement of cash
flows and a statement of stockholders’ equity as of the end of such year, such year-end financial reports to be in reasonable detail, prepared in accordance with GAAP, and audited and certified by independent public accountants of nationally
recognized 

  
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standing selected by the Company and approved by the Requisite Preferred Directors (as defined below); 

(b) as soon as practicable, but in any event within thirty (30) days after the end of each month and within forty five (45) days
after the end of each of the first three quarters of each fiscal year of the Company, an unaudited income statement for such month or quarter, as applicable, a balance sheet as of the end of such month or quarter, as applicable, and a statement of
cash flows as of the end of such month or quarter, as applicable; and 
 (c) such other financial information of the Company as such
Preferred Investor may reasonably request, including certificates of the principal financial officer of the Company concerning compliance with the covenants of the Company under this Section 6. 

6.2 Operating Plan; Other Reporting. The Company will prepare and deliver to each Preferred Investor at least thirty
(30) days prior to the end of each fiscal year, an annual operating plan (including a budget) prepared on a monthly basis and, promptly after preparation, any revisions to such operating plan. In addition, the Company will promptly provide to
each Preferred Investor other customary information and materials, including reports of adverse developments, management letters, communications with stockholders or directors, press releases, and registration statements. 

6.3 Inspection. The Company shall, upon reasonable prior notice to the Company, permit authorized representatives of the Preferred
Investors to visit and inspect any of the properties of the Company including its books of account (and to make copies thereof and take extracts therefrom), and to discuss the affairs, finances, and accounts of the Company with its officers,
administrative employees, and independent accountants, all at the expense of such Preferred Investors and at such reasonable times and as often as may be reasonably requested. 

6.4 Employee Agreements. The Company shall require all its present and future employees and consultants to enter into suitable
agreements with provisions governing, among other things, the protection of confidential information, assignment of intellectual property, competition with the Company, development rights and non-solicitation of the Company’s employees and
consultants. The agreements relating to competition with the Company and non-solicitation of the Company’s employees and consultants shall be, to the extent permitted by applicable state law, for terms of not less than a period of twelve
(12) months from the date of termination of employment of any such employee or consultant with the Company. The Company shall require all employees to execute and deliver a Proprietary Information and Inventions Agreement substantially in the
form attached hereto as Exhibit D. 
 6.5 Employee Stock Options. Except as otherwise approved by the Board,
including the Requisite Preferred Directors, any stock options or restricted stock awards granted by the Company to its employees shall vest according to the following schedule: 1/4th of the total number of shares subject to a stock option will vest
on the first anniversary of the date such option was granted and 1/48th of such number of shares will vest for each month of continuous service thereafter over the next 36 months. 

  
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 6.6 Reservation of Conversion Stock. The Company will, upon any increase in the
number of shares of Common Stock issuable upon conversion of the Preferred Stock, reserve additional shares of Common Stock for issuance upon such conversion, so that the number of shares of Common Stock so reserved will be adequate in the event of
such conversion. 
 6.7 Board Meetings. The Company agrees to hold meetings of its Board of Directors at least on a quarterly
basis or as agreed by the directors, including the Requisite Preferred Directors. 
 6.8 Qualified Small Business Stock. The
Company shall submit to the Internal Revenue Service any reports that may be required under Section 1202(d)(1)(C) of the Code and the related Treasury Regulations. In addition, within a commercially reasonable time after any Preferred Investor
has delivered to the Company a written request therefor, the Company shall deliver to such Preferred Investor a written statement indicating whether, to the knowledge of the Company, such Preferred Investor’s interest in the Company constitutes
“qualified small business stock” as defined in Section 1202(c) of the Code, or, at the election of the Company, a written statement containing such factual information available to the Company as may be reasonably required by the
Preferred Investor to permit the Preferred Investor or the Preferred Investor’s advisors to determine whether the Preferred Investor’s interest in the Company constitutes “qualified small business stock” as defined in
Section 1202(c) of the Code. 
 For purposes of this Agreement, the term “Requisite Preferred Directors” shall mean
(i) all of the Preferred Directors at such times as there are four (4) or fewer Preferred Directors sitting on the Board, (ii) four (4) of the Preferred Directors at such times as there are five (5) Preferred Directors
sitting on the Board, and (iii) a majority of the Preferred Directors at such times as there are six (6) or more Preferred Directors. The term “Preferred Directors” shall have the meaning ascribed thereto in the Voting Agreement.

 7. Participation Rights.

7.1 Definitions.
 (a)
“New Securities” shall mean (i) any capital stock of the Company whether or not currently authorized, (ii) all Options and (iii) all Convertible Securities. For purposes of this Section 7.1,
“Option” shall mean rights, options or warrants to subscribe for, purchase or otherwise acquire either Common Stock or Convertible Securities (as hereafter defined) and “Convertible Securities” shall mean any
evidences of indebtedness, shares (other than Common Stock or other stock issued on conversion of the Preferred Stock) or other securities, including preferred stock, directly or indirectly convertible into or exchangeable for capital stock of the
Company or other securities convertible into capital stock of the Company, but excluding Options. Notwithstanding the foregoing, the term “New Securities” shall not include the issuances or deemed issuances listed in Article Fourth,
Section 3.3(d)(i)(4)(A)-(L) of the Restated Certificate. 
 (b) “Preferred Holder” shall include, for the
purposes of this Section 7, the general partners, officers, or other affiliates of such Preferred Holder, and a Preferred Holder 

  
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may apportion its Pro Rata Share (as defined in Section 7.2 below) among itself and such general partners, officers, and other affiliates in such proportions as it deems appropriate.

 7.2 Participation Right. So long as at least fifteen percent (15%) of the shares of Preferred Stock outstanding on the
date hereof remain outstanding (after giving effect to the transactions contemplated to occur at the Second Closing), each Preferred Holder (as defined below) shall be entitled to a right to purchase, on a pro rata basis, all or any part of New
Securities which the Company may, from time to time, propose to sell and issue, subject to the terms and conditions set forth below. Such Preferred Holder’s pro rata share (the “Pro Rata Share”) shall equal the product of
(a) the New Securities being issued, multiplied by (b) a fraction, the numerator of which is the sum of (i) the number of shares of Common Stock issued or issuable upon conversion of the Preferred Stock then held by such Preferred
Holder and (ii) the number of Common Shares sold and issued to such Preferred Holder pursuant to Section 1.2 of this Agreement then held by such Preferred Holder, and the denominator of which is the total number of shares of Common
Stock then outstanding plus the number of shares of Common Stock issuable upon (x) conversion of then outstanding Preferred Stock; or other Convertible Securities and (y) exercise of then outstanding Options. 

7.3 Exercise of Right. In the event the Company intends to issue New Securities, it shall give each Preferred Holder written
notice of such intention, describing the type of New Securities to be issued, the price thereof, and the general terms upon which the Company proposes to effect such issuance (the “Sale Notice”). Each Preferred Holder shall have
twenty (20) days from the date of any Sale Notice to agree to purchase all or part of its Pro Rata Share of such New Securities for the price and upon the general terms and conditions specified in the Sale Notice by giving written notice to the
Company stating the quantity of New Securities to be so purchased (the “Exercise Notice”); provided, however, that in the event that the transaction described in a Sale Notice involves in whole or in part the payment
of non-cash consideration, or the payment of consideration over time, the Preferred Holders shall have the right to elect, upon exercise of their rights set forth in this Section 7, to pay to the Company in full consideration for the New
Securities the market price of such securities which shall be the present cash value of the consideration described in the Sale Notice as determined by the Board in good faith. 

7.4 Overallotment. In the event any Preferred Holder fails to exercise its right to purchase its Pro Rata Share of New Securities,
each Preferred Holder who delivered an Exercise Notice for such Preferred Holder’s total Pro Rata Share of New Securities (an “Overallotment Purchaser”) shall have a right to purchase such Overallotment Purchaser’s pro
rata share of the New Securities with respect to which Preferred Holders have failed to exercise their rights hereunder (the “Remaining New Securities”). In such case, within twenty-five (25) days after the date of the Sale
Notice, the Company shall provide written notice (the “Overallotment Notice”) to each Overallotment Purchaser, which shall state the total amount of Remaining New Securities, and the pro rata portion of such Remaining New Securities
which each Overallotment Purchaser is entitled to purchase. Each Overallotment Purchaser wishing to purchase such Remaining Securities shall amend such Overallotment Purchaser’s Exercise Notice in writing within ten (10) days from the date
of the Overallotment Notice. For the purpose of this Section 7.4, an Overallotment Purchaser’s pro 

  
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rata share of the Remaining New Securities shall be calculated as provided in Section 7.2, except that the denominator of the fraction shall be the sum of the total number of shares
of Common Stock issued or issuable upon conversion of shares of Preferred Stock held by all of the Overallotment Purchasers and the total number of Common Shares held by all Overallotment Purchasers that were issued pursuant to
Section 1.2 of this Agreement, but shall exclude shares of Common Stock issuable on conversion of other preferred stock or other convertible securities or on exercise of options, rights, or warrants. 

7.5 Closing. The closing of the purchase of New Securities by the Preferred Holders exercising their rights hereunder
(“Participating Purchasers”) shall take place at such location, date and time as the parties shall agree but not later than the later of (i) sixty (60) days following the date of the Sale Notice or (ii) thirty
(30) days following the date of the Overallotment Notice. At the closing, the Company shall deliver to the Participating Purchasers certificates representing all of the New Securities to be purchased and such other agreements executed by
the Company which grant any rights or privileges to the Participating Purchasers as are being granted to the other purchasers in such issuance, and in any event, at the request of the Participating Purchasers, a duly executed certificate reasonably
satisfactory to the Participating Purchasers containing a representation and warranty that, upon issuance or transfer of such securities to the Participating Purchasers that the Participating Purchasers will be the legal and beneficial owners of
such securities with good title thereto, free and clear of all mortgages, liens, charges, security interests, adverse claims, pledges, encumbrances and demands whatsoever, and that the Company has the absolute right to issue or transfer such
securities to the Participating Purchasers without the consent or approval of any other person. At the closing, the Participating Purchasers shall deliver to the Company (i) payment for the New Securities and (ii) such other agreements
executed by the other purchasers in such issuance which include representations by such purchasers to the Company or restrict such purchaser’s rights with respect to the New Securities, and in any event, at the request of the Company, a duly
executed certificate reasonably satisfactory to the Company containing such representations and warranties of the Participating Purchasers with respect to federal and state securities laws. The certificates representing the equity securities may
contain a legend stating that they are issued subject to the registration requirements of the Securities Act and applicable state securities laws. 

7.6 Failure to Exercise Right. In the event the Preferred Holders fail to exercise the foregoing participation right with respect
to any New Securities within the periods specified by Sections 7.3 and 7.4 above, the Company may within one hundred and twenty (120) days after the delivery of the Sale Notice sell any or all of such New Securities not
agreed to be purchased by the Preferred Holders, at a price and upon general terms no more favorable to the purchasers thereof than specified in the Sale Notice. In the event the Company has not sold such New Securities within such 120-day period,
the Company shall not thereafter issue or sell any New Securities without first offering such New Securities to the Preferred Holders in the manner provided in Section 7.3. 

7.7 Transfer of Participation Right. The participation right set forth in this Section 7 may not be assigned or
transferred, except that (i) such right is assignable by each Preferred Holder to any wholly owned subsidiary or parent of, or to any corporation or entity that is, 

  
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within the meaning of the Securities Act, controlling, controlled by or under common control with, any such Preferred Holder, (ii) such right is assignable between and among any of the
Preferred Holders, (iii) such right is assignable by a Preferred Holder that is a venture capital fund to an affiliated venture capital fund or partner or retired partner of such fund and (iv) such right is assignable to a holder of
Registrable Securities (as defined below). 
 8. Registration Rights. The Company covenants and agrees as follows: 

8.1 Definitions. As used in this Section 8, the following terms shall have the following meanings: 

(a) “Act” means the Securities Act of 1933, as amended. 

(b) “Form S-1” means such form under the Act as in effect on the date hereof, or any registration form under the Act
subsequently adopted by the SEC which permits the registration of securities under the Act for which no other form is authorized or prescribed. 

(c) “Form S-3” means such form under the Act as in effect on the date hereof or any registration form under the Act
subsequently adopted by the SEC which permits inclusion or incorporation of substantial information by reference to other documents filed by the Company with the SEC. 

(d) “Preferred Holder” means (i) a Purchaser and any persons or entities to whom the rights granted under this
Section 8 are transferred by the Purchaser, (ii) permitted transferees, successors or assigns as permitted under Section 9 below, (iii) a holder of shares of Seed Preferred Stock or Series A Preferred Stock,
(iv) with respect to Sections 8.2 to 8.13 inclusive (the “Applicable Sections”) only, a holder of shares of Common Stock issued upon conversion of Seed Preferred Stock or Series A Preferred Stock,
(v) with respect to the Applicable Sections only, Square 1 Bank and any registered assigns to which it transfers the rights granted under this Section 8 in accordance with Section 9(b) hereof (the
“Square 1 Entities”), and (vi) with respect to the Applicable Sections only, Oxford Finance LLC and any registered assigns to which it transfers the rights granted under this Section 8 in accordance with
Section 9(b) hereof (the “Oxford Entities”); provided, however that none of the Square 1 Entities or the Oxford Entities shall be permitted to be an Initiating Holder (as hereinafter defined) under
Section 8.2. 
 (e) “Holders” means (i) a Preferred Holder, including the Square 1 Entities and
Oxford Entities for purposes of the Applicable Sections, and (ii) Ram Sasisekharan, Alan L. Crane, The Crane Family Irrevocable Trust – 2002, the Sasisekharan Family 2006 Irrevocable Trust, the Sasisekharan Parents 2006 Irrevocable Trust,
the Narayanasami Parents 2006 Irrevocable Trust, S. Raguram and Mahesh Narayanasami and their Permitted Transferees (the “Founder Holders”). 

(f) “Immediate Family” shall mean any child, stepchild, grandchild, parent, stepparent, grandparent, spouse, sibling,
nephew, niece, mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law or sister-in-law and shall include adoptive relationships. 

  
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 (g) “Permitted Transferee” means, with respect to the Founder Holders,
(i) any member or members of a Founder Holder’s or such Founder Holder’s spouse’s Immediate Family to whom Registrable Securities are transferred; and (ii) any trust to which Registrable Securities are transferred
(A) in respect of which such Founder Holder serves as trustee, provided that the trust instrument governing such trust shall provide that such Founder Holder, as trustee, shall retain sole and exclusive control over the voting and
disposition of such Registrable Securities until the termination of this Section 8 or (B) for the benefit solely of any member or members of such Founder Holder’s or such Founder Holder’s spouse’s Immediate Family;
provided, that no person or entity shall be a Permitted Transferee unless (x) a written notice is furnished to the Company at the time of such transfer stating the name and address of the transferee and identifying the Registrable
Securities with respect to which such rights are being assigned and (y) the transferee agrees in writing to become bound by the terms and conditions of this agreement with respect to such Registrable Securities. 

(h) “1934 Act” shall mean the Securities Exchange Act of 1934, as amended. 

(i) The terms “register,” “registered,” and “registration” refer to a registration
effected by preparing and filing a registration statement or similar document in compliance with the Act, and the declaration or ordering of effectiveness of such registration statement or document. 

(j) “Registrable Securities” means (i) the Common Stock held by the Founder Holders and their Permitted Transferees,
(ii) the Common Stock issuable or issued upon conversion of the Preferred Stock, (iii) the Common Shares issued pursuant to Section 1.2 of this Agreement, (iv) the Common Stock issued or issuable upon conversion of the
shares of Preferred Stock issued or issuable upon exercise of the Warrants to Purchase Stock issued by the Company to Square 1 Bank and Oxford Finance LLC (the “Warrants”) in connection with that certain Loan and Security
Agreement, dated as of September 9, 2014, among the Company, Square 1 Bank and Oxford Finance LLC or, at all times when the Class (as defined in the Warrants) shall be Common Stock, the shares of Common Stock issued and issuable upon
exercise or conversion of the Warrants, (v) any additional shares of Common Stock issued to Square 1 Bank or Oxford Finance LLC in connection with the exercise of the Warrants, and (vi) any Common Stock of the Company issued as (or
issuable upon the conversion or exercise of any warrant, right, or other security which is issued as) a stock split, dividend or other distribution with respect to, or in exchange for or in replacement of, the shares referenced in (i) through
(v) above, excluding in all cases, however, any Registrable Securities sold by a person in a transaction in which the rights under this Section 8 are not properly assigned. 

(k) “Outstanding Registrable Securities” shall mean the number of shares of Common Stock outstanding that are, and the
number of shares of Common Stock issuable pursuant to then exercisable or convertible securities which are, Registrable Securities. 
 (l)
“SEC” shall mean the Securities and Exchange Commission. 

  
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 8.2 Demand Registration.

(a) If the Company shall receive, at any time after the earlier of (i) four years after the date of this Agreement or (ii) one
hundred eighty (180) days after the effective date of the registration statement for the Company’s first underwritten public offering of its common stock under the Act (such offering, the “IPO”), a written notice from the
Preferred Holders holding at least fifty percent (50%) of the Outstanding Registrable Securities then held by Preferred Holders requesting that the Company effect a registration statement under the Act with respect to all or a part of the
Registrable Securities held by such Preferred Holder or Preferred Holders, then the Company shall: 
 (i) within ten (10) days of the
receipt thereof, give written notice of such request to all Preferred Holders, other than the Initiating Holders (as defined below) (the “Demand Notice”); and 

(ii) use its best efforts to effect as soon as practicable, and in any event within ninety (90) days of the receipt of such request by
the Initiating Holders, the registration under the Act of all Registrable Securities which the Preferred Holders request to be registered, by notice to the Company within thirty (30) days of the mailing of the Demand Notice sent by the Company
in accordance with Section 8.2(a)(i), subject to the limitations of subsections 8.2(b), 8.2(c) and 8.2(d). 

(b) If the Preferred Holders initiating the registration request hereunder (“Initiating Holders”) intend to distribute the
Registrable Securities covered by their request by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to subsection 8.2(a) and the Company shall include such information in the Demand
Notice. The underwriter will be selected by the Company and shall be reasonably acceptable to the Initiating Holders holding a majority of the Outstanding Registrable Securities requested to be included in such registration. In such event, the right
of any Preferred Holder to include Registrable Securities in such registration shall be conditioned upon such Preferred Holder’s participation in such underwriting and the inclusion of such Preferred Holder’s Registrable Securities in the
underwriting (unless otherwise mutually agreed by a majority in interest of the Initiating Holders and such Preferred Holder) to the extent provided herein. All Preferred Holders proposing to distribute their securities through such underwriting
shall (together with the Company as provided in subsection (e)) enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting. Notwithstanding any other provision of this
Section 8.2, if the underwriter advises the Initiating Holders in writing that marketing factors require a limitation of the number of shares to be underwritten, then the Initiating Holders shall so advise all Preferred Holders of
Registrable Securities which would otherwise be underwritten pursuant hereto, and the number of shares of Registrable Securities that may be included in the underwriting shall be allocated among all Preferred Holders thereof, including the
Initiating Holders, in proportion (as nearly as practicable) to the amount of Registrable Securities of the Company owned by each Preferred Holder; provided, however, that the number of shares of Registrable Securities to be included
in such underwriting shall not be reduced unless all other securities are first entirely excluded from the underwriting. 

  
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 (c) Notwithstanding the foregoing, if the Company shall furnish to Preferred Holders requesting
registration pursuant to this Section 8.2 a certificate signed by the President of the Company stating that in the good faith judgment of the Board it would be seriously detrimental to the Company for a registration statement to be filed
and it is therefore essential to defer the filing of such registration statement, then the Company shall have the right to defer taking action with respect to such filing for a period of not more than one hundred twenty (120) days after receipt
of the request of the Initiating Holders. 
 (d) In addition, the Company shall not be obligated to effect, or to take any action to
effect, any registration pursuant to this Section 8.2 after the Company has effected two (2) registrations on Form S-1 pursuant to this Section 8.2 and each such registration statement has been declared or ordered
effective and the sales of Registrable Securities under such registration statement have closed. 
 (e) No incidental right under this
Section 8.2 shall be construed to limit any registration required under Section 8.3 or Section 8.4 herein. 

8.3 “Piggy-Back” Registration.

(a) If (but without any obligation to do so) the Company proposes to register (including for this purpose a registration effected by the
Company for stockholders other than the Holders) any of its stock or other securities under the Act in connection with the public offering of such securities solely for cash, other than (i) a registration relating solely to the sale of
securities to participants in a stock plan, (ii) a registration on any form which does not include substantially the same information as would be required to be included in a registration statement covering the sale of the Registrable
Securities, or (iii) a registration on Form S-4 (or any successor form) relating solely to a transaction pursuant to the SEC’s Rule 145, the Company shall, at such time, promptly give each Holder written notice of such registration. Upon
the written request of each Holder given within twenty (20) days after the mailing of such notice by the Company in accordance with Section 11.7, the Company shall, subject to the provisions of subsection 8.3(b), cause
to be registered under the Act all of the Registrable Securities that each such Holder has requested to be registered. 
 (b) In connection
with any offering involving an underwriting of shares of the Company’s capital stock, the Company shall not be required under this Section 8.3 to include any of the Holders’ securities in such underwriting unless such Holders accept
the terms of the underwriting as agreed upon between the Company and the underwriters selected by it (or by other persons entitled to select the underwriters), and then only in such quantity as the underwriters determine in their sole discretion
will not jeopardize the success of the offering by the Company. If the total amount of securities, including Registrable Securities, requested by stockholders to be included in such offering exceeds the amount of securities to be sold (other than by
the Company) that the underwriters determine in their sole discretion is compatible with the success of the offering, then the Company shall be required to include in the offering only that number of such securities, including Registrable
Securities, which the underwriters determine in their sole discretion will not jeopardize the success of the offering; provided, however, there shall first be excluded from such 

  
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registration statement all shares of Common Stock sought to be included therein by (i) any director, consultant, officer, or employee of the Company or any subsidiary thereof other than the
Founder Holders and (ii) stockholders exercising any contractual or incidental registration rights subordinate and junior to the rights of the Preferred Holders of Registrable Securities. If after such shares are excluded, the underwriters
shall determine in their sole discretion that the number of securities which remain to be included in the offering exceeds the amount of securities to be sold that the underwriters determine is compatible with the success of the offering, then there
shall second be excluded from such registration statement all shares of Common Stock sought to be included therein by the Founder Holders. If after such additional shares are excluded, the underwriters shall determine in their sole discretion that
the number of securities which remain to be included in the offering exceeds the amount of securities to be sold that the underwriters determine is compatible with the success of the offering, then the Registrable Securities to be included, if any,
shall be apportioned pro rata among the Holders other than Founder Holders providing notice of their desire to participate in the offering according to the total amount of securities entitled to be included therein owned by each such selling Holder
or in such other proportions as shall mutually be agreed to by such Holders, provided, however, that no exclusion of such Holders’ Registrable Securities shall be made unless all other stockholders’ securities are first
excluded. For purposes of the preceding sentence concerning apportionment, for any selling Holder which is a partnership or corporation, the partners, retired partners, and stockholders of such Holder, or the estates and family members of any such
partners and retired partners and any trusts for the benefit of any of the foregoing persons shall be deemed to be a single “selling Holder,” and any pro-rata reduction with respect to such “selling Holder” shall be based upon
the aggregate amount of shares carrying registration rights owned by all entities and individuals included in such “selling Holder,” as defined in this sentence. 

(c) No incidental right under this Section 8.3 shall be construed to limit any registration required under
Section 8.2 or Section 8.4 herein. 
 8.4 Form S-3 Registration. In case the Company shall receive from
one or more Preferred Holders that, individually or together with such Preferred Holder’s affiliates, holds at least $10,000,000 of the Registrable Securities a written request or requests that the Company effect a registration on Form S-3 with
respect to all or a part of the Registrable Securities owned by such Preferred Holder(s), the Company agrees: 
 (a) to promptly give
written notice of the proposed registration (the “S-3 Notice”) to all other Preferred Holders, if any; and 
 (b) as soon
as practicable after receiving such a request, use its commercially reasonable efforts to effect such registration as would permit or facilitate the sale and distribution of all or such portion of such Preferred Holder’s or Preferred
Holders’ Registrable Securities as are specified in such request, together with all or such portion of the Registrable Securities of any other Preferred Holder(s) joining in such request as are specified in a written request given within
fifteen (15) days after the S-3 Notice is given by the Company; provided, however, that the Company shall not be obligated to effect any such registration pursuant to this Section 8.4 (i) if Form S-3 is not
available for such offering by the Preferred Holder(s); (ii) if the 

  
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Preferred Holder(s), together with the holders of any other securities of the Company entitled to inclusion in such registration, propose to sell Registrable Securities and such other securities
(if any) at an aggregate price to the public of less than $1,000,000; (iii) if the Company shall furnish to the Preferred Holder(s) a certificate signed by the President of the Company stating that it would be in the good faith judgment of the
underwriters seriously detrimental to the Company for such Form S-3 registration to be effected at such time, in which event the Company shall have the right to defer the filing of the Form S-3 registration statement for a period of not more than
sixty (60) days after receipt of the request of the Preferred Holder(s) under this Section 8.4; provided, however, that the Company shall not utilize this right more than once in any eighteen month period; or
(iv) if the Company has effected two (2) registrations on Form S-3 (or its then equivalent) pursuant to this Section 8.4 within the previous 12-month period and such registrations have been declared or ordered effective and the
sales of Registrable Securities under such registration statement have closed. 
 (c) Registrations effected pursuant to this
Section 8.4 shall not be counted as demands for registration or registrations effected pursuant to Sections 8.2 or 8.3, respectively. 

8.5 Obligations of the Company. Whenever required under this Section 8 to effect the registration of any Registrable
Securities, the Company shall, as expeditiously as reasonably possible (but subject to providing counsel to the Holders with a reasonable opportunity to review and comment on all documents): 

(a) Prepare and file with the SEC a registration statement with respect to such Registrable Securities and use its best efforts to cause such
registration statement to become effective, and, upon the request of the Holders of a majority of the Registrable Securities registered thereunder, keep such registration statement effective for a period of up to one hundred twenty (120) days
or, if earlier, until the distribution contemplated in the Registration Statement has been completed; provided, however, that (i) such 120-day period shall be extended for a period of time equal to the period the Holder refrains
from selling any securities included in such registration at the request of an underwriter of Common Stock (or other securities) of the Company and (ii) in the case of any registration of Registrable Securities on Form S-3 which are intended to
be offered on a continuous or delayed basis, such 120-day period shall be extended, if necessary, to keep the registration statement effective until all such Registrable Securities are sold or could be sold without restriction under SEC Rule
144(b)(1)(i); provided, that SEC Rule 415, or any successor rule under the Act, permits an offering on a continuous or delayed basis; and provided further that applicable rules under the Act governing the obligation to file a
post-effective amendment permit, in lieu of filing a post-effective amendment which (x) includes any prospectus required by Section 10(a)(3) of the Act or (y) reflects facts or events representing a material or fundamental change in
the information set forth in the registration statement, the incorporation by reference of information required to be included in (x) and (y) above to be contained in periodic reports filed pursuant to Section 13 or 15(d) of the 1934
Act in the registration statement. 
 (b) Prepare and file with the SEC such amendments and supplements to such registration statement and
the prospectus used in connection with such registration statement as 

  
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may be necessary to comply with the provisions of the Act with respect to the disposition of all securities covered by such registration statement in accordance with each Holder’s intended
method of disposition. 
 (c) Furnish to the Holders such numbers of copies of a prospectus, including a preliminary prospectus, in
conformity with the requirements of the Act, and such other documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by the Holders. 

(d) Use its best efforts to register and qualify the securities covered by such registration statement under such other securities or Blue
Sky laws of such jurisdictions as shall be reasonably requested by the Holders and any managing underwriter; provided, that the Company shall not be required in connection therewith or as a condition thereto to qualify to do business or to
file a general consent to service of process in any such states or jurisdictions, unless the Company is already subject to service in such jurisdiction and except as may be required by the Act. 

(e) In the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and
customary form, with the managing underwriter of such offering. Each Holder participating in such underwriting shall also enter into and perform its obligations under such an agreement. 

(f) Promptly notify each Holder of Registrable Securities covered by such registration statement at any time when a prospectus relating
thereto is required to be delivered under the Act as a result of the happening of any event as a result of which the prospectus included in such registration statement, as then in effect, includes an untrue statement of a material fact or omits to
state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing. 

(g) Cause all such Registrable Securities registered pursuant hereunder to be listed on each securities exchange on which similar securities
issued by the Company are then listed. 
 (h) Provide a transfer agent and registrar for all Registrable Securities registered pursuant
hereunder and a CUSIP number for all such Registrable Securities, in each case not later than the effective date of such registration. 

(i) Furnish, at the request of any Holder requesting registration of Registrable Securities pursuant to this Section 8, on the
date that such Registrable Securities are delivered to the underwriters for sale in connection with a registration pursuant to this Section 8, if such securities are being sold through underwriters, copies of (i) the opinion, dated
as of such date, of the counsel representing the Company for the purposes of such registration given to the underwriters in such underwritten public offering, which opinion shall be in such form as is reasonably satisfactory to counsel to the
underwriters, and (ii) the letter dated as of such date, from the independent certified public accountants of the Company, to the underwriters in such 

  
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underwritten public offering, addressed to the underwriters, which letter shall be in such form as is reasonably satisfactory to counsel to the underwriters. 

8.6 Furnish Information. It shall be a condition precedent to the obligations of the Company to take any action pursuant to this
Section 8 with respect to the Registrable Securities of any selling Holder that such Holder shall furnish to the Company such information regarding itself, the Registrable Securities held by it, and the intended method of disposition of
such securities as shall be required to effect the registration of such Holder’s Registrable Securities. 
 8.7 Expenses of Demand
and S-3 Registrations. The Company shall pay all expenses other than underwriting discounts and commissions incurred in connection with registrations, filings, or qualifications pursuant to Sections 8.2 and 8.4, including
(i) all registration, filing, and qualification fees (including filing fees with the SEC, fees due to the Financial Industry Regulatory Authority and fees due for listing on any stock exchange); (ii) printers and accounting fees;
(iii) fees and disbursements of counsel for the Company; and (iv) the reasonable fees and disbursements of one counsel for the selling Preferred Holders; provided, however, that the Company shall not be required to pay for
any expenses of any registration proceeding begun pursuant to Sections 8.2 or 8.4 if the registration request is subsequently withdrawn at the request of the holders of a majority of the Registrable Securities then held by
Preferred Holders to be registered (in which case all Preferred Holders participating in the aborted registration shall bear such expenses on a pro rata basis in accordance with the number of Registrable Securities requested to be registered by such
Preferred Holders), unless the holders of a majority of the Registrable Securities then held by Preferred Holders agree to forfeit their rights to a registration under, as the case may be, Section 8.2 (demand registration) or
Section 8.4 (S-3 registration); provided further, however, that if at the time of such withdrawal, the Preferred Holders have either (i) learned of a material adverse change in the condition or business, or
prospects of the Company from that known to the Preferred Holders at the time of their request or (ii) been informed by the underwriters of such registration that more than twenty percent (20%) of the Registrable Securities requested for
registration shall not be includable therein due to market factors, and in either such case the Preferred Holders have withdrawn the request with reasonable promptness following such disclosure, then the Preferred Holders shall not be required to
pay such expenses and shall retain their rights pursuant to Sections 8.2 and 8.4. 
 8.8 Expenses of
“Piggy-Back” Registration. The Company shall pay all expenses incurred in connection with any registration, filing, or qualification of Registrable Securities with respect to the registrations pursuant to Section 8.3
for each Holder, including all registration, filing, and qualification fees, printers and accounting fees relating or apportionable thereto, and the reasonable fees and disbursements of one counsel for the selling Holders selected by them, but
excluding underwriting discounts and commissions relating to the Registrable Securities. 
 8.9 Delay of Registration. No Holder
shall have any right to obtain or seek an injunction restraining or otherwise delaying any such registration as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 8.

  
 -28- 

 8.10 Indemnification. In the event any Registrable Securities are included in a
registration statement under this Section 8: 
 (a) To the extent permitted by law, the Company will indemnify and hold
harmless each Holder, any underwriter (as defined in the Act) for such Holder, the members, partners, officers, directors and stockholders of each Holder, and each person (if any) who controls such Holder or underwriter within the meaning of the Act
or the 1934 Act, against any losses, claims, damages, or liabilities joint or several) to which they may become subject under the Act, the 1934 Act, other federal or state law, or the laws of any other jurisdiction insofar as such losses, claims,
damages, or liabilities (or actions in respect thereof) arise out of or are based upon any of the following statements, omissions, or violations (collectively a “Violation”) (i) any untrue statement or alleged untrue statement
of a material fact contained in such registration statement, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto, (ii) the omission or alleged omission to state therein a material
fact required to be stated therein, or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation by the Company of the Act, the 1934 Act, any state securities law, or any rule or regulation promulgated
under the Act, the 1934 Act, or any state securities law; and the Company will pay to each such Holder, underwriter, or controlling person, as incurred, any legal or other expenses reasonably incurred by them in connection with investigating or
defending any such loss, claim, damage, liability, or action; provided, however, that the indemnity agreement contained in this subsection 8.10(a) shall not apply to amounts paid in settlement of any such loss, claim,
damage, liability, or action if such settlement is effected without the consent of the Company (which consent shall not be unreasonably withheld), nor shall the Company be liable in any such case for any such loss, claim, damage, liability, or
action to the extent that it arises out of or is based upon a Violation which occurs in reliance upon and in conformity with written information furnished expressly for use in connection with such registration by any such Holder, underwriter, or
controlling person. 
 (b) To the extent permitted by law, each selling Holder severally and not jointly will indemnify and hold harmless
the Company, each of its directors, each of its officers, each person (if any) who controls the Company within the meaning of the Act, any underwriter, any other Holder selling securities in such registration statement, and any controlling person of
any such underwriter or other Holder, against any losses, claims, damages, or liabilities joint or several) to which any of the foregoing persons may become subject, under the Act, the 1934 Act or other federal or state law, insofar as such losses,
claims, damages, or liabilities (or actions in respect thereto) arise out of or are based upon any Violation, in each case to the extent (and only to the extent) that such Violation occurs in reliance upon and in conformity with written information
furnished by such Holder expressly for use in connection with such registration; and each such Holder will pay, as incurred, any legal or other expenses reasonably incurred by any person intended to be indemnified pursuant to this
subsection 8.10(b), in connection with investigating or defending any such loss, claim, damage, liability, or action; provided, however, that the indemnity agreement contained in this subsection 8.10(b) shall
not apply to amounts paid in settlement of any such loss, claim, damage, liability, or action if such settlement is effected without the consent of the Holder, which consent shall not be unreasonably withheld; and further provided that in no
event shall any 

  
 -29- 

 
indemnity under this subsection 8.10(b) exceed the proceeds from the offering received by such Holder (net of any selling expenses paid by such Holder). 

(c) Promptly after receipt by an indemnified party under this Section 8.10 of notice of the commencement of any action (including
any governmental action), such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Section 8.10, deliver to the indemnifying party a written notice of the commencement thereof and
the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly with any other indemnifying party similarly noticed, to assume the defense thereof with counsel mutually satisfactory to the
parties; provided, however, that an indemnified party (together with all other indemnified parties which may be represented without conflict by one counsel) shall have the right to retain one separate counsel and participate in the
defense, with the fees and expenses to be paid by the indemnifying party, if representation of such indemnified party by the counsel retained by the indemnifying party would be inappropriate due to actual or potential differing interests between
such indemnified party and any other party represented by such counsel in such proceeding. The failure to deliver written notice to the indemnifying party within a reasonable time of the commencement of any such action, if prejudicial to its ability
to defend such action, shall relieve such indemnifying party of any liability to the indemnified party under this Section 8.10, but the omission so to deliver written notice to the indemnifying party will not relieve it of any liability
that it may have to any indemnified party otherwise than under this Section 8.10. 
 (d) If the indemnification provided for in
this Section 8.10 is held by a court of competent jurisdiction to be unavailable to an indemnified party with respect to any loss, liability, claim, damage, or expense referred to therein, then the indemnifying party, in lieu of
indemnifying such indemnified party hereunder, shall contribute to the amount paid or payable by such indemnified party as a result of such loss, liability, claim, damage, or expense in such proportion as is appropriate to reflect the relative fault
of the indemnifying party, on the one hand, and of the indemnified party, on the other, in connection with the statements or omissions that resulted in such loss, liability, claim, damage, or expense as well as any other relevant equitable
considerations; provided, however, that no contribution by any Holder, when combined with any amounts paid by such Holder pursuant to Section 8.10(b), shall exceed the proceeds from the offering received by such Holder (net
of any selling expenses paid by such Holder). The relative fault of the indemnifying party and of the indemnified party shall be determined by a court of competent jurisdiction by reference to, among other things, whether the untrue or alleged
untrue statement of a material fact or the omission to state a material fact relates to information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information, and
opportunity to correct or prevent such statement or omission. 
 (e) Notwithstanding the foregoing, to the extent that the provisions on
indemnification and contribution contained in the underwriting agreement entered into in connection with the underwritten public offering are in conflict with the foregoing provisions, the provisions in the underwriting agreement shall control;
provided, however, that the failure of the underwriting agreement to address a provision addressed in this Agreement shall not be deemed a conflict. 

  
 -30- 

 (f) Unless otherwise superseded by an underwriting agreement as provided in
Section 8.10(e) above, the obligations of the Company and Holders under this Section 8.10 shall survive the completion of any offering of Registrable Securities in a registration statement under this Section 8,
and otherwise. 
 8.11 Reports Under the 1934 Act. With a view to making available to the Holders the benefits of SEC Rule 144
and any other rule or regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the public without registration or pursuant to a registration on Form S-3, the Company agrees to use its best efforts: 

(a) to make and keep public information available, as those terms are understood and defined in SEC Rule 144, at all times after ninety
(90) days after the effective date of the first registration statement filed by the Company for the offering of its securities to the general public; 

(b) to take such action, including the voluntary registration of its Common Stock under Section 12 of the 1934 Act, as is necessary to
enable the Holders to utilize Form S-3 for the sale of their Registrable Securities, such action to be taken as soon as practicable after the end of the fiscal year in which the first registration statement filed by the Company for the offering of
its securities to the general public is declared effective; 
 (c) to file with the SEC in a timely manner all reports and other documents
required of the Company under the Act and the 1934 Act; and 
 (d) to furnish to any Holder, so long as the Holder owns any Registrable
Securities, forthwith upon request (i) a written statement by the Company that it has complied with the reporting requirements of SEC Rule 144 (at any time after ninety (90) days after the effective date of the first registration statement
filed by the Company), the Act and the 1934 Act (at any time after it has become subject to such reporting requirements), or that it qualifies as a registrant whose securities may be resold pursuant to Form S-3 (at any time after it so qualifies),
(ii) a copy of the most recent annual or quarterly report of the Company and such other reports and documents so filed by the Company, and (iii) such other information as may be reasonably requested in availing any Holder of any rule or
regulation of the SEC which permits the selling of any such securities without registration or pursuant to such form. 
 8.12
“Market Stand-Off” Agreement. Each Holder hereby agrees that, during a period of 180 days following the effective date of a registration statement of the Company filed under the Act relating to the IPO of the Company, plus up
to an additional 34 days to the extent requested by the managing underwriter(s) for such offering in order to address Rule 2711(f) of the Financial Industry Regulatory Authority, Inc. or any similar successor provision (such period, the
“Lock-Up Period”), such Holder shall not, to the extent requested by the Company and such managing underwriter(s), directly or indirectly sell, offer to sell, contract to sell (including any short sale), grant any option to
purchase, or otherwise transfer or dispose of (other than to donees who agree to be similarly bound) any securities of the Company held by it at any time during such period except Common Stock included in such registration; provided,
however, that all officers and 

  
 -31- 

 
directors of the Company, Founder Holders and stockholders holding in excess of one percent (1%) of the outstanding Common Stock of the Company (treating all Preferred Stock on an
as-converted to Common Stock basis) enter into similar agreements. Any discretionary waiver or termination by the Company or the underwriters of the restrictions described in this Section 8.12 as applied to any Holder, officer or
director or stockholder holding in excess of one percent (1%) of the outstanding Common Stock of the Company (treating all Preferred Stock on an as-converted to Common Stock basis) of the Company (the “Subject Parties”) shall
apply pro rata to all Holders subject to such restrictions, based on the number of shares held by each Holder that are subject to such restrictions, except that, notwithstanding the foregoing, the Company and the underwriters may, in their sole
discretion, waive or terminate these restrictions with respect to (i) the exercise or conversion of stock options, warrants and other convertible securities that would otherwise expire during the Lock-Up Period and (ii) up to an aggregate
of 100,000 shares of Common Stock held by the Subject Parties. 
 In order to enforce the foregoing covenant, the Company may impose
stop-transfer instructions with respect to the Registrable Securities of a Holder (and the shares or securities of every other person subject to the foregoing restriction) until the end of such period. 

Notwithstanding the foregoing, the obligations described in this Section 8.12 shall not apply to a registration relating solely to
employee benefit plans on Form S-1 or Form S-8 or similar forms which may be promulgated in the future, or a registration relating solely to a SEC Rule 145 transaction on Form S-4 or similar forms which may be promulgated in the future. 

8.13 Termination of Registration Rights. No Holder shall be entitled to exercise any right provided for in this
Section 8 following the earliest to occur of: 
 (a) when all of such Holder’s Registrable Securities have been sold; 

(b) when (i) the Company has completed its IPO and (ii) all of such Holder’s (and its affiliates’) Registrable Securities
may be sold without restriction under SEC Rule 144(b)(1)(i); and 
 (c) the fifth anniversary of the IPO. 

9. Transfers and Assignment.

9.1 Assignment of Certain Rights.

(a) The rights granted to a Purchaser pursuant to Section 1.2(b) of this Agreement may be transferred or assigned by such
Purchaser to (i) any person or entity to which Shares are transferred by such Purchaser or (ii) any person or entity who, directly or indirectly, controls, is controlled by or is under common control with such Purchaser, and, in each case,
such transferee shall be deemed a Purchaser for purposes of this Agreement. 
 (b) The rights granted to the Preferred Holders under
Sections 7 and 8 of this Agreement may be transferred or assigned to (i) any other Preferred Investor or any current or 

  
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former general or limited partner, retired partner, member, shareholder, parent, child, spouse, trust or other affiliate of any Preferred Investor, (ii) any Permitted Transferees or
(iii) any other person or entity that acquires at least 25% of the transferor’s Registrable Securities. 
 (c) Notwithstanding
anything to the contrary in clauses (a) and (b), (i) no such transfer or assignment may be made to a party that is reasonably deemed a competitor of the Company by the Board, (ii) the Company must be, within a reasonable time after
such transfer or assignment, furnished with written notice of the transfer or assignment, including the name and address of such transferee or assignee; and (iii) no such transfer or assignment may be made unless such transferee or assignee
agrees in a written instrument delivered to the Company to be bound by and subject to the terms and conditions of this Agreement, including the provisions of Section 8.12. 

9.2 Subsequent Transfers. A transferee to whom rights are transferred or assigned pursuant to this Section 9 may not
again transfer or assign such rights to any other person or entity, other than as provided in Section 9.1 above. 
 10.
Confidentiality.
 10.1 Confidential Information. Each Preferred Holder and Founder Holder agrees that such Preferred
Holder or Founder Holder shall keep confidential and shall not disclose or use (other than to monitor its investment in the Company) this Agreement and all Schedules and Exhibits hereto, the Financing Agreements, and all other documents delivered in
connection with any Closing, and also any confidential, proprietary, or secret information that it has or may obtain from the Company, unless such confidential information (a) is known or becomes known to the public in general (other than as a
result of a breach of this Section 10 by such Preferred Holder), (b) is or has been independently developed or conceived by the Preferred Holder or Founder Holder without use of the Company’s confidential information, or
(c) is or has been made known or disclosed to the Preferred Holder or Founder Holder by a third party without a breach of any obligation of confidentiality such third party may have to the Company; provided, however, that a
Preferred Holder or Founder Holder may disclose confidential information (i) to its attorneys, accountants, consultants, and other professionals to the extent necessary to obtain their services in connection with monitoring its investment in
the Company and negotiating the terms thereof; (ii) to any prospective purchaser of any Registrable Securities from such Preferred Holder or Founder Holder, if such prospective purchaser agrees to be bound by the provisions of this
Section 10; (iii) to any affiliate, partner, member, stockholder, or wholly owned subsidiary of such Preferred Holder or Founder Holder in the ordinary course of business, provided that such Preferred Holder or Founder Holder
informs such Person that such information is confidential and directs such Person to maintain the confidentiality of such information; or (iv) as may otherwise be required by law, court order or subpoena, provided that the Preferred
Holder or Founder Holder promptly notifies the Company of such disclosure and takes reasonable steps to minimize the extent of any such required disclosure. 

10.2 Foundation. Any announcement of the Foundation’s investment in the Company by any other party, including the Company,
its representatives, directors, stockholders and agents, or any Purchaser, Preferred Investor, Preferred Holder or Founder Holder, will require the Foundation’s prior written approval. Such parties shall also obtain the Foundation’s prior
written 

  
 -33- 

 
approval for any other use of the Foundation’s name or logo in any respect; provided, however, that the Company may use the Foundation’s name for any uses that have been
pre-approved in writing by the Foundation. Notwithstanding the foregoing, the Foundation’s name and logo will not be used by any party in any manner to market, sell or otherwise promote such party, its product, services and/or other business.

 11. Miscellaneous.

11.1 Survival of Representations and Warranties. The warranties, representations, and covenants of the Company and the Purchasers
contained in or made pursuant to this Agreement shall survive the execution and delivery of this Agreement and such Closing. Notwithstanding the right of the Company and the Purchasers to fully investigate the affairs of the other party and
notwithstanding any knowledge of facts determined or determinable by such party pursuant to such investigation or right of investigation, each party has the right to rely fully upon the representations, warranties, covenants and agreements of each
other party in this Agreement or in any Schedule, Exhibit, certificate or financial statement delivered by any party pursuant hereto. 

11.2 Termination of Certain Provisions. The obligations of the Company set forth in Sections 6 and 7 shall terminate
upon the consummation of a Qualified IPO (as defined in the Restated Certificate). 
 11.3 Expenses. Except as otherwise
expressly provided in this Agreement, each of the parties will bear its own expenses in connection with the preparation of the Financing Agreements and the consummation of the transactions contemplated thereby. Notwithstanding the foregoing,
(i) in the case of the First Closing, the Company shall pay the fees and expenses of Butler Snow LLP, counsel to Merck Sharp & Dohme Corp., incurred in connection with its due diligence review of the Company, the negotiation and
execution of the Financing Agreements and the consummation of the transactions contemplated thereby in an amount not to exceed $25,000.00; and (ii) in the case of the Second Closing, the fees and expenses of Wilson Sonsini Goodrich &
Rosati, P.C., counsel to V-Sciences Investments Pte Ltd and Vertex USA Fund Pte. Ltd., incurred in connection with its due diligence review of the Company, the negotiation and execution of the Financing Agreements and the consummation of the
transactions contemplated thereby in an amount not to exceed $25,000.00. 
 11.4 Successors and Assigns. Except as otherwise
provided herein, the terms and conditions of this Agreement shall inure to the benefit of and be binding upon the respective successors and assigns of the Company and the Holders (including transferees of any shares of Preferred Stock or any Common
Stock issued upon conversion thereof, and the Permitted Transferees of the Founder Holders with respect to their rights and obligations under Section 8 hereof). Nothing in this Agreement, express or implied, is intended to confer upon
any party other than the parties hereto or their respective successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement. 

  
 -34- 

 11.5 Governing Law. This Agreement shall be governed by, and construed and enforced
in accordance with, the laws of the state of Delaware without regard to its principles of conflicts of laws. 
 11.6
Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. This Agreement may be executed by facsimile
signatures or as a pdf or similar attachment to an electronic transmission. 
 11.7 Construction. A reference to a Section or
Schedule shall mean a Section in or Schedule to this Agreement unless otherwise expressly stated. The titles and headings herein are for reference purposes only and shall not in any manner limit the construction of this Agreement which shall be
considered as a whole. The words “include,” “includes” and “including” when used herein shall be deemed in each case to be followed by the words “without limitation.” Whenever the context may require, any
pronouns used herein shall include the corresponding masculine, feminine or neuter forms, and the singular form of names and pronouns shall include the plural and vice-versa. 

11.8 Notices. All notices, requests, consents, and other communications under this Agreement shall be in writing and shall be
deemed effectively given: (a) upon personal delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the recipient, and if not so confirmed, then on the next
business day, (c) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one (1) business day after the business day of deposit with a nationally recognized
overnight courier, specifying next business day delivery, with written verification of receipt. All communications shall be sent to the respective parties as follows: 

If to the Company: 
 Visterra,
Inc. 
 One Kendall Square, Suite B3301 

Cambridge, MA 02139 
 Attn:
Brian Pereira 
 Fax: (617) 498-1073 

with a copy to: 
 Lia Der
Marderosian, Esq. 
 WilmerHale LLP 

60 State Street 
 Boston, MA
02109 
 Fax: 617-526-5000 

If to the Purchasers, to their respective addresses set forth on Schedule 1 or Schedule 2 to this Agreement. 

  
 -35- 

 If to the Founder Holders, to their respective addresses set forth on the signature pages hereto.

 Any party may change its address or facsimile number at any time upon written notice as provided in this Section. 

11.9 Brokers. The Company and the Purchasers, each severally and not jointly, (i) represent and warrant to the other parties
hereto that it has retained no finder or broker in connection with the transactions contemplated by this Agreement and (ii) shall indemnify and hold harmless the other parties from and against any and all claims, liabilities, or obligations
with respect to brokerage or finders’ fees or commissions or consulting fees in connection with the transactions contemplated by this Agreement, asserted by any person on the basis of any statement or representation alleged to have been made by
such indemnifying party. 
 11.10 Amendments and Waivers. Except as otherwise expressly set forth in this Agreement, any term of
this Agreement may be amended and the observance of any term of this Agreement may be waived (either generally or in a particular instance and either retroactively or prospectively), with the written consent of the Company and the holders of more
than seventy percent (70%) of the then outstanding Series B Shares being sold pursuant to this Agreement or shares of Common Stock issued upon conversion thereof; provided, however, (i) Sections 6 and
7 may be amended, and the observance of any term of such sections may be waived, with the written consent of the Company and holders of more than seventy percent (70%) of the then outstanding shares of Preferred Stock, with each share of
Seed Preferred Stock and Series A Preferred Stock having one vote and each share of Series B Preferred Stock having 1.25 votes for purposes of such vote, or shares of Common Stock issued upon conversion thereof, and
(ii) Sections 8 and 9 may be amended, and the observance of any term of such Sections may be waived, with the written consent of the Company and the holders of more than seventy percent (70%) of the Outstanding
Registrable Securities held by Preferred Holders entitled to rights, or subject to obligations, under such subsection, in each case, either generally or in a particular instance and either retroactively or prospectively. Any amendment, termination,
or waiver effected in accordance with this Section 11.10 shall be binding on all parties hereto, regardless of whether any such party has consented thereto. No waivers of or exceptions to any term, condition, or provision of this
Agreement, in any one or more instances, shall be deemed to be, or construed as, a further or continuing waiver of any such term, condition, or provision. 

11.11 Severability. If one or more provisions of this Agreement are held to be invalid, illegal or unenforceable under applicable
law, it shall, as to such jurisdiction, be deemed modified to conform to the minimum requirements of such law or regulation, or, if for any reason it is not deemed so modified, it shall be invalid, illegal or unenforceable only to the extent of such
invalidity, illegality or limitation on enforceability without affecting the remaining provisions of this Agreement, or the validity, legality or enforceability of such provision in any other jurisdiction. 

11.12 Aggregation of Stock. All shares of Registrable Securities, Preferred Stock or Common Stock held or acquired by Purchasers or
Holders shall be aggregated together with the Registrable Securities, Preferred Stock or Common Stock held or acquired by any entity with which 

  
 -36- 

 
such Purchaser or Holder is affiliated for the purpose of determining the availability of any rights under this Agreement. 

11.13 Entire Agreement. This Agreement and the documents referred to herein constitute the entire agreement among the parties
relating to the subject matter set forth herein and therein, and supersede any other agreement, written or oral, among the parties relating to such subject matter. This Agreement will be deemed to amend and restate the Original Agreement in its
entirety and will be deemed to further amend and restate Section 6 through 11 of the Amended and Restated Series A Convertible Preferred Stock and Warrant Purchase Agreement, dated as of September 12, 2012, as amended,
by and among the Company and the other parties named therein. No party shall be liable or bound to any other party in any manner relating to the subject matter set forth herein or therein by any warranties, representations, or covenants except as
specifically set forth herein or therein. 
 11.14 Delays or Omissions. No delay or omission to exercise any right, power or
remedy accruing to any party upon any breach or default of another party under this Agreement shall impair any such right, power or remedy of such party nor shall it be construed to be a waiver of any such breach or default, or an acquiescence
therein, or of or in any similar breach or default thereafter occurring; nor shall any waiver of any single breach or default be deemed a waiver of any other breach or default theretofore or thereafter occurring. Any waiver, permit, consent or
approval of any kind or character on the part of any holder of any breach or default under this Agreement, or any waiver on the part of any holder of any provisions or conditions of this Agreement, must be in writing and shall be effective only to
the extent specifically set forth in such writing. All remedies, either under this Agreement or by law or otherwise afforded to any party shall be cumulative and not alternative. 

[Remainder of page intentionally left blank.] 

  
 -37- 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Series B Convertible
Preferred Stock Purchase Agreement as of the date first written above. 
  

									
		 		 	VISTERRA, INC.
				
		 		 	By:	 	 /s/ Brian Pereira

		 		 	Name:	 	Brian Pereira
		 		 	Title:	 	President and Chief Executive Officer
				
	PURCHASERS:	 		 		 	
				
	Merck Sharp & Dohme Corp.	 		 		 	
					
	By:	 	 /s/ Robert M. Davis
	 		 		 	
	Name:	 	Robert M. Davis	 		 		 	
	Title:	 	EVP & Chief Financial Officer	 		 		 	
			
	POLARIS VENTURE PARTNERS FOUNDERS’ FUND V, L.P.	 		 	POLARIS VENTURE PARTNERS V, L.P.
			
	By: POLARIS VENTURE MANAGEMENT CO. V, L.L.C.	 		 	By: POLARIS VENTURE MANAGEMENT CO. V, L.L.C.
	Its: General Partner	 		 	Its: General Partner
					
	By:	 	 /s/ William Bilodeau
	 		 	By:	 	 /s/ William Bilodeau

	Name:	 	William Bilodeau	 		 	Name:	 	William Bilodeau
	Title:	 	Attorney-in-Fact	 		 	Title:	 	Attorney-in-Fact
			
	POLARIS VENTURE PARTNERS SPECIAL FOUNDERS’ FUND V, L.P.	 		 	POLARIS VENTURE PARTNERS ENTREPRENEURS’ FUND V, L.P.
			
	By: POLARIS VENTURE MANAGEMENT CO. V, L.L.C. its General Partner	 		 	By: POLARIS VENTURE MANAGEMENT CO. V, L.L.C. its General Partner
					
	By:	 	 /s/ William Bilodeau
	 		 	By:	 	 /s/ William Bilodeau

	Name:	 	William Bilodeau	 		 	Name:	 	William Bilodeau
	Title:	 	Attorney-in-Fact	 		 	Title:	 	Attorney-in-Fact

  
 [Signature Page to
Amended and Restated Series B Convertible Preferred Stock Purchase Agreement] 

									
	PURCHASERS (CONT.):	 	
		
	FLAGSHIP VENTURES FUND IV, L.P.	 	
		
	By:	 	FLAGSHIP VENTURES FUND IV GENERAL PARTNER L.L.C.
	Its:	 	General Partner	 		 		 	
					
	By:	 	 /s/ Edwin Kania
	 		 		 	
	Name:	 	Edwin Kania	 		 		 	
	Title:	 	Manager	 		 		 	
		
	FLAGSHIP VENTURES FUND IV-Rx, L.P.	 	
		
	By:	 	FLAGSHIP VENTURES FUND IV GENERAL PARTNER L.L.C.
	Its:	 	General Partner	 		 		 	
					
	By:	 	 /s/ Edwin Kania
	 		 		 	
	Name:	 	Edwin Kania	 		 		 	
	Title:	 	Manager	 		 		 	
		
	V-Sciences Investment Pte Ltd	 	
					
	By:	 	 /s/ Fidah Alsagoff
	 		 		 	
	Name:	 	Fidah Alsagoff	 		 		 	
	Title:	 	Authorized Signatory	 		 		 	
		
	Vertex USA Fund Pte. Ltd.	 	
					
	By:	 	 /s/ Pang Seow Lan
	 		 		 	
	Name:	 	Pang Seow Lan	 		 		 	
	Title:	 	Director	 		 		 	

  
 [Signature Page to
Amended and Restated Series B Convertible Preferred Stock Purchase Agreement] 

									
	PURCHASERS (CONT.):	 		 		 	
	
	ALEXANDRIA EQUITIES, LLC, a Delaware limited liability company
					
	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, INC.	 		 		 	
	a Maryland corporation, managing member	 		 	
					
	By:	 	 /s/ Jennifer Banks
	 		 		 	
	Name:	 	Jennifer Banks	 		 		 	
	Title:	 	EVP, General Counsel	 		 		 	
				
	OMEGA CAMBRIDGE SPV, L.P.	 		 		 	
	By:	 	Omega Cambridge SPV GP, LLC	 		 		 	
	Its:	 	General Partner	 		 		 	
					
	By:	 	 /s/ Richard Lim
	 		 		 	
	Name:	 	Richard Lim	 		 		 	
	Title:	 	Manager	 		 		 	
				
	 /s/ Brian J G Pereira
	 		 		 	
	Brian J G Pereira	 		 		 	
	
	CYCAD GROUP, LLC, a California limited liability company
				
	 /s/ K. Leonard Judson
	 		 		 	
	By:	 	K. Leonard Judson	 		 		 	
	Its:	 	President & Managing Director	 		 		 	
				
	 /s/ James Delaney
	 		 		 	
	James Delaney	 		 		 	

  
 [Signature Page to
Amended and Restated Series B Convertible Preferred Stock Purchase Agreement] 

									
	PURCHASERS (CONT.):	 		 		 	
				
	 /s/ David Arkowitz
	 		 		 	
	David Arkowitz	 		 		 	

  
 [Signature Page to
Amended and Restated Series B Convertible Preferred Stock Purchase Agreement] 

									
	ACCEPTED AND AGREED TO AS TO
	THE PROVISIONS OF SECTIONS 6
	THROUGH 11:	 		 		 	
				
	LUX VENTURES II, L.P.	 		 		 	
					
	By:	 	Lux Venture Partners II, L.P.	 		 		 	
	Its:	 	General Partner	 		 		 	
	By:	 	Lux Venture Associates II, LLC	 		 		 	
	Its:	 	General Partner	 		 		 	
	By:	 	Lux Capital Management, LLC	 		 		 	
	Its:	 	Sole Member	 		 		 	
					
	By:	 	 /s/ Peter Hebert
	 		 		 	
	Name:	 	Peter Hebert	 		 		 	
	Title:	 	Managing Director	 		 		 	
				
	LUX VENTURES II SIDECAR, L.P.	 		 		 	
					
	By:	 	Lux Venture Partners II, L.P.	 		 		 	
	Its:	 	General Partner	 		 		 	
	By:	 	Lux Venture Associates II, LLC	 		 		 	
	Its:	 	General Partner	 		 		 	
	By:	 	Lux Capital Management, LLC	 		 		 	
	Its:	 	Sole Member	 		 		 	
					
	By:	 	 /s/ Peter Hebert
	 		 		 	
	Name:	 	Peter Hebert	 		 		 	
	Title:	 	Managing Director	 		 		 	

  
 [Signature Page to
Amended and Restated Series B Convertible Preferred Stock Purchase Agreement] 

									
	ACCEPTED AND AGREED TO AS TO
	THE PROVISIONS OF SECTIONS 6	 		 		 	
	THROUGH 11:	 		 		 	
				
	BILL & MELINDA GATES FOUNDATION	 		 		 	
					
	By:	 	 /s/ Andrew Farnum
	 		 		 	
	Name:	 	Andrew Farnum	 		 		 	
	Title:	 	Deputy Director, Program Related Investments	 		 		 	
				
	BRIAN J G PEREIRA IRREVOCABLE TRUST	 		 		 	
					
	By:	 	 /s/ Michael J. Moran, a Trustee and not individually
	 		 		 	
	Name:	 	Michael J. Moran	 		 		 	
	Title:	 	Trustee	 		 		 	

  
 [Signature Page to
Amended and Restated Series B Convertible Preferred Stock Purchase Agreement] 

									
	ACCEPTED AND AGREED TO AS TO
	THE PROVISIONS OF SECTIONS 6
	THROUGH 11:	 		 		 	
	
	FLAGSHIP VENTURES FUND 2007, L.P.
		
	By:	 	FLAGSHIP VENTURES 2007 GENERAL PARTNER L.L.C.
	Its:	 	General Partner	 		 		 	
					
	By:	 	 /s/ Edwin Kania
	 		 		 	
	Name:	 	Edwin Kania	 		 		 	
	Title:	 	Manager	 		 		 	

  
 [Signature Page to
Amended and Restated Series B Convertible Preferred Stock Purchase Agreement] 

									
	ACCEPTED AND AGREED TO AS TO
	 THE PROVISIONS OF SECTIONS 6

THROUGH 11:

				
	 /s/ Alan L. Crane
	 		 		 	
	Alan L. Crane	 		 		 	
				
	 /s/ Ram Sasisekharan
	 		 		 	
	Ram Sasisekharan	 		 		 	
	
	The Crane Family Irrevocable Trust – 2002
					
	By:	 	 /s/ Howard R. Crane
	 		 		 	
	Name:	 	Howard R. Crane	 		 		 	
	Title:	 	Trustee	 		 		 	
	
	Sasisekharan Family 2006 Irrevocable Trust
					
	By:	 	 /s/ Kenneth S. Federman, trustee
	 		 		 	
	Name:	 	Kenneth S. Federman	 		 		 	
	Title:	 	Trustee	 		 		 	
	
	Sasisekharan Parents 2006 Irrevocable Trust
					
	By:	 	 /s/ Kenneth S. Federman, trustee
	 		 		 	
	Name:	 	Kenneth S. Federman	 		 		 	
	Title:	 	Trustee	 		 		 	
	
	Narayanasami Parents 2006 Irrevocable Trust
					
	By:	 	 /s/ Kenneth S. Federman, trustee
	 		 		 	
	Name:	 	Kenneth S. Federman	 		 		 	
	Title:	 	Trustee	 		 		 	

  
 [Signature Page to
Amended and Restated Series B Convertible Preferred Stock Purchase Agreement] 

									
	ACCEPTED AND AGREED TO AS TO	 		 		 	
	THE PROVISIONS OF SECTIONS 6	 		 		 	
	THROUGH 11:	 		 		 	
				
	 /s/ S. Raguram
	 		 		 	
	S. Raguram	 		 		 	
				
	 /s/ Mahesh Narayanasami
	 		 		 	
	Mahesh Narayanasami	 		 		 	

  
 [Signature Page to
Amended and Restated Series B Convertible Preferred Stock Purchase Agreement] 

 VISTERRA, INC. 

Counterpart Signature Page 
 to

 Fourth Amended and Restated Voting Agreement, as amended 

Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement, as amended 

By executing and delivering this signature page, the undersigned Purchaser hereby joins in, becomes a party to and agrees to be bound by the
terms and conditions of: 
 (i) that certain Fourth Amended and Restated Voting Agreement, dated as of May 15, 2014, as amended, and as
may be further amended and/or restated from time to time, by and among the Company and the Stockholders named therein (the “Voting Agreement”) as an “Investor” and “Stockholder” thereunder; and 

(ii) that certain Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement, dated as of May 15, 2014, as amended, and as
may be further amended and/or restated from time to time, by and among the Company and the Stockholders named therein (the “Right of First Refusal and Co-Sale Agreement”) as an “Investor” thereunder. 

The undersigned Purchaser hereby authorizes this signature page to be attached to the Voting Agreement and the Right of First Refusal and
Co-Sale Agreement or counterparts thereof. 
  

									
	AGREED TO AND ACCEPTED:	 		 	PURCHASER:
			
	VISTERRA, INC.	 		 	[Name]
					
	By:	 	  
	 		 	By:	 	  

	Name:	 		 		 	Name:	 	
	Title:	 		 		 	Title:	 	
			
	Date:                  , 2014	 		 	Date:                  , 2014

 SCHEDULE 1 

FIRST CLOSING 
  

													
	 Name
	  	Number of First
Closing Series B
Shares	 	  	Purchase Price
for First Closing
Series B Shares	 	  	Number of
Common
Shares	 
	 Merck Sharp & Dohme Corp.
	  	 	6,000,000	  	  	$	7,500,000	  	  	 	1,500,000	  
	 Polaris Venture Partners V, L.P.
	  	 	2,782,783	  	  	$	3,478,478.75	  	  	 	695,695	  
	 Polaris Venture Partners Entrepreneurs’ Fund V, L.P.
	  	 	54,236	  	  	$	67,795.00	  	  	 	13,559	  
	 Polaris Venture Partners Founders’ Fund V, L.P.
	  	 	19,062	  	  	$	23,827.50	  	  	 	4,765	  
	 Polaris Venture Partners Special Founders’ Fund V, L.P.
	  	 	27,828	  	  	$	34,785.00	  	  	 	6,957	  

  
 S1-1 

													
	 Name
	  	Number of First
Closing Series B
Shares	 	  	Purchase Price
for First Closing
Series B Shares	 	  	Number of
Common
Shares	 
	 Flagship Ventures Fund IV, L.P.
	  	 	2,092,890	  	  	$	2,616,112.50	  	  	 	523,222	  
	 Flagship Ventures Fund IV-Rx, L.P.
	  	 	523,223	  	  	$	654,028.75	  	  	 	130,805	  
	 Omega Cambridge SPV, L.P.
	  	 	383,315	  	  	$	479,143.75	  	  	 	95,828	  
	 Alexandria Equities, LLC
	  	 	76,663	  	  	$	95,828.75	  	  	 	19,165	  
	 Brian J G Pereira
	  	 	40,000	  	  	$	50,000.00	  	  	 	10,000	  
	 TOTAL
	  	 	12,000,000	  	  	$	15,000,000	  	  	 	2,999,996	  

 SECOND CLOSING 
  

													
	 Name
	  	Number of
Second Closing
Series B Shares	 	  	Purchase Price
for Second
Closing Series B
Shares	 	  	Number of
Common
Shares	 
	 Merck Sharp & Dohme Corp.*
	  	 	2,000,000	  	  	$	2,500,000.00	  	  	 	500,000	  
	 Cycad Group, LLC
	  	 	1,400,000	  	  	$	1,750,000.00	  	  	 	350,000	  
	 Polaris Venture Partners V, L.P.*
	  	 	186,868	  	  	$	233,585.00	  	  	 	46,717	  
	 Polaris Venture Partners Entrepreneurs’ Fund V, L.P.*
	  	 	3,642	  	  	$	4,552.50	  	  	 	910	  
	 Polaris Venture Partners Founders’ Fund V, L.P.*
	  	 	1,280	  	  	$	1,600.00	  	  	 	320	  
	 Polaris Venture Partners Special Founders’ Fund V, L.P.*
	  	 	1,869	  	  	$	2,336.25	  	  	 	467	  
	 Flagship Ventures Fund IV, L.P.*
	  	 	140,541	  	  	$	175,676.25	  	  	 	35,135	  
	 Flagship Ventures Fund IV-Rx, L.P.*
	  	 	35,135	  	  	$	43,918.75	  	  	 	8,783	  
	 Omega Cambridge SPV, L.P.*
	  	 	25,554	  	  	$	31,942.50	  	  	 	6,388	  
	 Alexandria Equities, LLC*
	  	 	5,111	  	  	$	6,388.75	  	  	 	1,277	  
	 V-Sciences Investment Pte Ltd
	  	 	5,200,000	  	  	$	6,500,000.00	  	  	 	1,300,000	  

													
	 Name
	  	Number of
Second Closing
Series B Shares	 	  	Purchase Price
for Second
Closing Series B
Shares	 	  	Number of
Common
Shares	 
	 Vertex USA Fund Pte. Ltd.
	  	 	2,800,000	  	  	$	3,500,000.00	  	  	 	700,000	  
	 Brian Pereira*
	  	 	40,000	  	  	$	50,000.00	  	  	 	10,000	  
	 David Arkowitz
	  	 	24,000	  	  	$	30,000.00	  	  	 	6,000	  
	 James Delaney
	  	 	136,000	  	  	$	170,000.00	  	  	 	34,000	  
	 TOTAL
	  	 	12,000,000	  	  	$	15,000,000.00	  	  	 	2,999,997	  

  

	*	Address shown above 

 EXHIBIT A 

Form of Restated Certificate 

 AMENDED AND RESTATED 

CERTIFICATE OF INCORPORATION 

OF 
 VISTERRA, INC.

 (Pursuant to Sections 242 and 245 of the 

General Corporation Law of the State of Delaware) 

Visterra, Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the State of
Delaware (the “General Corporation Law”), 
 DOES HEREBY CERTIFY: 

1. That the name of this corporation is Visterra, Inc. (the “Corporation”), and that the Corporation was originally
incorporated pursuant to the General Corporation Law on December 20, 2007 under the name Parasol Therapeutics, Inc. The original Certificate of Incorporation of the Corporation was amended on each of January 18, 2008, May 13, 2008,
July 30, 2008, November 30, 2009, April 20, 2010, September 2, 2010, November 5, 2010 and February 23, 2011, was amended and restated on May 11, 2012 was further amended on each of September 12, 2012,
November 1, 2012 and November 6, 2013, and was amended and restated on May 14, 2014. 
 2. That the Board of Directors duly
adopted resolutions proposing to amend and restate the Certificate of Incorporation of the Corporation, as amended, declaring said amendment and restatement to be advisable and in the best interests of the Corporation and its stockholders, and
authorizing the appropriate officers of the Corporation to solicit the consent of the stockholders therefor, which resolution setting forth the proposed amendment and restatement is as follows: 

RESOLVED, that the Certificate of Incorporation of the Corporation be amended and restated in its entirety to read as follows: 

FIRST: The name of the Corporation is: Visterra, Inc. 

SECOND: The address of the Corporation’s registered office in the State of Delaware is Corporation Trust Center, 1209 Orange
Street, in the City of Wilmington, County of New Castle. The name of its registered agent at such address is The Corporation Trust Company. 

THIRD: The nature of the business or purposes to be conducted or promoted by the Corporation is to engage in any lawful act or activity
for which corporations may be organized under the General Corporation Law of Delaware. 
 FOURTH: The number of authorized shares of
each class or series of stock of the Corporation, and the powers, preferences and rights, and the qualifications, limitations or restrictions thereof, shall be as follows: 

 SECTION 1 

CAPITAL STOCK 
 The total
number of shares of all classes of stock which the Corporation shall have authority to issue is one hundred sixty one million three hundred seventy eight thousand six hundred thirty three (161,378,633) shares, consisting of ninety eight million
(98,000,000) shares of common stock, $0.0001 par value per share (the “Common Stock”), and sixty three million three hundred seventy eight thousand six hundred thirty three (63,378,633) shares of preferred stock, $0.01 par
value per share (the “Preferred Stock”). 
 SECTION 2 

COMMON STOCK 
 2.1
Voting Rights. The holders of shares of Common Stock shall be entitled to one vote for each share so held with respect to all matters voted on by the stockholders of the Corporation, subject in all cases to Sections 3.4 and 3.6 of this
Article Fourth. 
 Except as otherwise provided in the Corporation’s Amended and Restated Certificate of Incorporation (this
“Amended and Restated Certificate of Incorporation”), the number of authorized shares of Common Stock may be increased or decreased (but not below the number of shares thereof then outstanding) by the affirmative vote of the holders
of shares of stock of the Corporation representing a majority of the votes represented by all outstanding shares of stock of the Corporation entitled to vote, irrespective of the provisions of Section 242(b)(2) of the General Corporation Law of
Delaware. 
 2.2 Liquidation Right. Subject to the prior and superior right of the Preferred Stock, upon any voluntary or involuntary
liquidation, dissolution or winding up of the affairs of the Corporation, the holders of Common Stock shall be entitled to receive that portion of the remaining funds to be distributed to holders of Common Stock, subject to and as provided in
Section 3.2 of this Article Fourth. 
 2.3 Dividends. Dividends may be declared and paid on the Common Stock from funds lawfully
available therefor as, when and if declared by the Board of Directors, subject to any preferential dividend rights of any then outstanding Preferred Stock, including as provided in Section 3.5 of this Article Fourth. 

SECTION 3 

PREFERRED STOCK 
 3.1
Designation. Of the sixty three million three hundred seventy eight thousand six hundred thirty three (63,378,633) shares of Preferred Stock, six million six hundred eleven thousand five hundred sixty one (6,611,561) shares have
been designated as Seed Convertible Preferred Stock (the “Seed Preferred Stock”), thirty two million four hundred forty seven thousand seventy two 

  
 -2- 

 
(32,447,072) shares have been designated as Series A Convertible Preferred Stock (the “Series A Preferred Stock”) and twenty four million three hundred twenty thousand
(24,320,000) shares have been designated as Series B Convertible Preferred Stock (the “Series B Preferred Stock”). 

3.2 Liquidation Rights. 

(a) In the event of any Liquidating Event, each holder of a share of Seed Preferred Stock, Series A Preferred Stock or Series B
Preferred Stock shall be entitled to receive, prior and in preference to any distribution of any of the assets or surplus funds of the Corporation to the holders of Common Stock or any other class or series of stock ranking on liquidation junior to
the Seed Preferred Stock, Series A Preferred Stock or Series B Preferred Stock, by reason of such holder’s ownership thereof, an amount per share of Seed Preferred Stock equal to the Seed Original Issue Price (as defined below), an
amount per share of Series A Preferred Stock equal to the Series A Original Issue Price (as defined below) and an amount per share of Series B Preferred Stock equal to the Series B Original Issue Price (as defined below), plus in
each case an amount equal to any declared but unpaid dividends on such series of Preferred Stock to and including the date full payment shall be tendered to the holders of such series of Preferred Stock with respect to such liquidation, dissolution
or winding up (the amounts payable pursuant to this sentence are hereinafter referred to as the “Seed Liquidation Amount,” the “Series A Liquidation Amount” and the “Series B Liquidation
Amount,” respectively, and, collectively, as the “Liquidation Amounts”). If the assets or surplus funds to be distributed to the holders of the Seed Preferred Stock, Series A Preferred Stock and Series B Preferred
Stock pursuant to this Section 3.2(a) are insufficient to permit the payment to such holders of the full amount to which they shall be entitled, the assets and surplus funds legally available for distribution shall be distributed ratably among
the holders of the Seed Preferred Stock, Series A Preferred Stock and Series B Preferred Stock in proportion to the full Liquidation Amount each such holder is otherwise entitled to receive pursuant to this Section 3.2(a). 

(b) All of the Liquidation Amounts to be paid to the holders of the Preferred Stock pursuant to this Section 3.2 in the event of a
Liquidating Event shall be paid or set apart for payment before the payment or setting apart for payment of any amount for, or the distribution of any assets of the Corporation to, the holders of the Common Stock in connection with such Liquidating
Event. Subject to the provisions of Section 3.2(c) below, after payment or the setting apart of payment to the holders of the Preferred Stock of the Liquidation Amounts so payable to them, all remaining assets available for distribution (after
payment or provision for payment of all debts and liabilities of the Corporation) shall be distributed to the holders of the Common Stock ratably in proportion to the number of shares of Common Stock they then hold. 

(c) Notwithstanding anything in this Section 3.2 to the contrary, if a holder of any share of Preferred Stock would receive a greater
amount pursuant to this Section 3.2 with respect to such share of Preferred Stock upon a Liquidating Event by voluntarily converting such share into Common Stock immediately prior to such Liquidating Event at the then-applicable Conversion
Price (as defined below) than such holder would be entitled to receive with respect to such share of Preferred Stock pursuant to this Section 3.2, then such holder shall not receive any Liquidation Amount with respect to such share under such
Section 3.2(a), but shall be treated, for the purposes of determining such holder’s rights with respect to such share under Section 3.2(a) only, as though such holder had converted such share of Preferred Stock into Common Stock,
effective immediately prior 

  
 -3- 

 
to the applicable Liquidating Event, at the then-applicable Conversion Price for such series of Preferred Stock. 

(d) A “Liquidating Event” shall mean (1) a liquidation, dissolution or winding up of the Corporation, either voluntary
or involuntary, (2) a merger or consolidation in which either (I) the Corporation is a constituent party or (II) a subsidiary of the Corporation is a constituent party and the Corporation issues shares of its capital stock pursuant to
such merger or consolidation, except any such merger or consolidation involving the Corporation or a subsidiary in which the shares of capital stock of the Corporation outstanding immediately prior to such merger or consolidation continue to
represent, or are converted into or exchanged for shares of capital stock that represent, immediately following such merger or consolidation, at least a majority, by voting power, of the capital stock of (i) the surviving or resulting
corporation or (ii) if the surviving or resulting corporation is a wholly owned subsidiary of another corporation immediately following such merger or consolidation, the parent corporation of such surviving or resulting corporation, or
(3) the sale, lease, transfer, exclusive license or other disposition, in a single transaction or series of related transactions, by the Corporation or any subsidiary of the Corporation of all or substantially all the assets of the Corporation
and its subsidiaries taken as a whole, or the sale or disposition (whether by merger or otherwise) of one or more subsidiaries of the Corporation if substantially all of the assets of the Corporation and its subsidiaries taken as a whole are held by
such subsidiary or subsidiaries, except where such sale, lease, transfer, exclusive license or other disposition is to a wholly owned subsidiary of the Corporation; provided, however, that such a transaction shall not be regarded as a
Liquidating Event and, to the extent applicable, all outstanding shares of Preferred Stock shall be treated under the provisions of Section 3.3(d)(vii) in lieu of this Section 3.2 in connection with such sale, merger or consolidation in
the event that the holders of more than seventy percent (70%) in voting power (as determined pursuant to Section 3.4 hereof) of the then-outstanding shares of Preferred Stock so elect, by written notice to the Corporation no later than
fifteen (15) days before the effective date of such event. 
 (e) The Corporation shall not have the power to effect a Liquidating
Event referred to in Section 3.2(d)(2)(I) unless the agreement or plan of merger or consolidation for such transaction (the “Merger Agreement”) provides that the consideration payable to the stockholders of the Corporation
shall be allocated among the holders of capital stock of the Corporation in accordance with this Section 3.2. 
 (f) In the event of a
Liquidating Event referred to in Subsection 3.2(d)(2)(II) or 3.2(d)(3), if the Corporation does not effect a dissolution of the Corporation under the Delaware General Corporation Law within 90 days after such Liquidating Event, unless the holders of
more than seventy percent (70%) in voting power (as determined pursuant to Section 3.4 hereof) of the then-outstanding shares of Preferred Stock request otherwise in a written instrument delivered to the Corporation prior to the
Liquidation Redemption Date (as defined below), the Corporation shall use the consideration received by the Corporation for such Liquidating Event (net of any retained liabilities associated with the assets sold or technology licensed, as determined
in good faith by the Board of Directors of the Corporation), together with any other assets of the Corporation available for distribution to its stockholders, all to the extent permitted by Delaware law governing distributions to stockholders (the
“Available Proceeds”), on the 150th day after such Liquidating Event (the “Liquidation Redemption Date”), to redeem all outstanding shares of Preferred Stock at 

  
 -4- 

 
a price per share equal to the amounts per share that each holder would be entitled to receive under this Section 3.2 upon a Liquidating Event in which the Available Proceeds were the amount
available to the stockholders of the Corporation. Notwithstanding the foregoing, in the event of a redemption pursuant to the preceding sentence, if the Available Proceeds are not sufficient to redeem all outstanding shares of Preferred Stock, the
Corporation shall redeem a pro rata portion of each holder’s shares of Preferred Stock to the fullest extent of such Available Proceeds, based on the respective amounts which would otherwise be payable in respect of the shares to be redeemed if
the Available Proceeds were sufficient to redeem all such shares, and shall redeem the remaining shares to have been redeemed as soon as practicable after it may lawfully do so under Delaware law governing distributions to stockholders. Prior to the
distribution or redemption provided for in this Section 3.2(f), the Corporation shall not expend or dissipate the consideration received for such Liquidating Event, except to discharge expenses incurred in connection with such Liquidating
Event. 
 (g) In connection with a redemption pursuant to Section 3.2(f), the Corporation shall send a written notice (a
“Redemption Notice”) to each holder of Preferred Stock no later than the 90th day after the Liquidating Event advising such holders of their redemption rights pursuant to Section 3.2(f). Each Redemption Notice shall state: 

(i) the number of shares of Preferred Stock held by the holder that the Corporation is obligated to redeem pursuant to Section 3.2(f);

 (ii) the Liquidation Redemption Date; 

(iii) the Liquidation Amount payable for each series of Preferred Stock; and 

(iv) the manner and place designated for the holder to surrender his, her or its certificate or certificates representing shares of Preferred
Stock if such shares are to be redeemed. 
 (h) On or before the Liquidation Redemption Date, each holder of shares of Preferred Stock to be
redeemed on such Liquidation Redemption Date, unless such holder has exercised his, her or its right to convert such shares as provided in Section 3.3, shall surrender the certificate or certificates representing such shares (or, if such holder
alleges that such certificate has been lost, stolen or destroyed, a lost certificate affidavit and agreement reasonably acceptable to the Corporation to indemnify the Corporation against any claim that may be made against the Corporation on account
of the alleged loss, theft or destruction of such certificate) to the Corporation, in the manner and at the place designated in the Redemption Notice, and thereupon the Liquidation Amount for such shares shall be payable to the order of the person
whose name appears on such certificate or certificates as the owner thereof. In the event less than all of the shares of Preferred Stock represented by a certificate are redeemed, a new certificate representing the unredeemed shares of Preferred
Stock shall promptly be issued to such holder. 
 (i) If the Redemption Notice has been duly given, and if on the applicable Liquidation
Redemption Date the Liquidation Amount is paid or tendered for payment or deposited with an independent payment agent so as to be available therefor in a timely manner, then notwithstanding that the certificates evidencing any of the shares of
Preferred Stock so called for 

  
 -5- 

 
redemption shall not have been surrendered, all rights with respect to such shares shall forthwith after the Liquidation Redemption Date terminate, except only the right of the holders to receive
the Liquidation Amount payable for such shares, without interest, upon surrender of the certificate or certificates therefor. 
 (j) The
amount deemed paid or distributed to the holders of capital stock of the Corporation upon any such Liquidating Event shall be the cash or the value of the property, rights or securities paid or distributed to such holders by the Corporation or the
acquiring person, firm or other entity. If the amount deemed paid or distributed under this Section 3.2(j) is made in property other than in cash, the value of such distribution shall be the fair market value of such property, determined as
follows: 
 (i) For securities not subject to investment letters or other similar restrictions on free marketability, 

(1) if traded on a securities exchange, the value shall be deemed to be the average of the closing prices of the securities on such exchange
or market over the 30-day period ending three days prior to the closing of such transaction; 
 (2) if actively traded over-the-counter,
the value shall be deemed to be the average of the closing bid prices over the 30-day period ending three days prior to the closing of such transaction; or 

(3) if there is no active public market, the value shall be the fair market value thereof, as determined in good faith by the Board of
Directors of the Corporation. 
 (ii) The method of valuation of securities subject to investment letters or other similar restrictions on
free marketability (other than restrictions arising solely by virtue of a stockholder’s status as an affiliate or former affiliate) shall take into account an appropriate discount (as determined in good faith by the Board of Directors of the
Corporation) from the market value as determined pursuant to clause (i) above so as to reflect the approximate fair market value thereof. 

(k) In the event of a Liquidating Event pursuant to Section 3.2(d)(2)(I), if any portion of the consideration payable to the stockholders
of the Corporation is placed into escrow and/or is payable to the stockholders of the Corporation subject to contingencies, the Merger Agreement shall provide that (a) the portion of such consideration that is not placed in escrow and not
subject to any contingencies (the “Initial Consideration”) shall be allocated among the holders of capital stock of the Corporation in accordance with this Section 3.2 as if the Initial Consideration were the only consideration
payable in connection with such Liquidating Event and (b) any additional consideration which becomes payable to the stockholders of the Corporation upon release from escrow or satisfaction of contingencies shall be allocated among the holders
of capital stock of the Corporation in accordance with this Section 3.2 after taking into account the previous payment of the Initial Consideration as part of the same transaction. 

  
 -6- 

 3.3 Conversion. The holders of Preferred Stock shall have conversion rights as follows
(the “Conversion Rights”): 
 (a) Right to Convert. 

(i) Each share of Seed Preferred Stock shall be convertible at the option of the holder thereof at any time after the date of issuance and
without the payment of any additional consideration therefor into that number of fully paid and nonassessable shares of Common Stock as is determined by dividing the Seed Original Issue Price (as defined below) by the Seed Conversion Price (as
defined below) as adjusted pursuant to this Section 3.3 and in effect at the time of conversion. The “Seed Original Issue Price” shall mean $1.00 per share, subject to appropriate adjustment in the event of any stock dividend,
stock split, combination or other similar recapitalization affecting such shares. The conversion price for the Seed Preferred Stock shall initially be equal to $1.00 (the “Seed Conversion Price”). The Seed Conversion Price shall be
subject to adjustment (in order to adjust the number of shares of Common Stock into which the Seed Preferred Stock is convertible) as hereinafter provided. Each person so converting shares of Seed Preferred Stock shall be entitled to all declared
but unpaid dividends up to the time of the conversion. Such dividends shall be paid to each such person within thirty (30) days of the date of conversion. 

(ii) Each share of Series A Preferred Stock shall be convertible at the option of the holder thereof at any time after the date of
issuance and without the payment of any additional consideration therefor into that number of fully paid and nonassessable shares of Common Stock as is determined by dividing the Series A Original Issue Price (as defined below) by the
Series A Conversion Price (as defined below) as adjusted pursuant to this Section 3.3 and in effect at the time of conversion. The “Series A Original Issue Price” shall mean $1.00 per share, subject to appropriate
adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization affecting such shares. The conversion price for the Series A Preferred Stock shall initially be equal to $1.00 (the “Series A
Conversion Price”). The Series A Conversion Price shall be subject to adjustment (in order to adjust the number of shares of Common Stock into which the Series A Preferred Stock is convertible) as hereinafter provided. Each person
so converting shares of Series A Preferred Stock shall be entitled to all declared but unpaid dividends up to the time of the conversion. Such dividends shall be paid to each such person within thirty (30) days of the date of conversion.

 (iii) Each share of Series B Preferred Stock shall be convertible at the option of the holder thereof at any time after the date of
issuance and without the payment of any additional consideration therefor into that number of fully paid and nonassessable shares of Common Stock as is determined by dividing the Series B Original Issue Price (as defined below) by the
Series B Conversion Price (as defined below) as adjusted pursuant to this Section 3.3 and in effect at the time of conversion. The “Series B Original Issue Price” shall mean $1.25 per share, subject to appropriate
adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization affecting such shares. The conversion price for the Series B Preferred Stock shall initially be equal to $1.25 (the “Series B
Conversion Price”). The Series B Conversion Price shall be subject to adjustment (in order to adjust the number of shares of Common Stock into which the Series B Preferred Stock is convertible) as hereinafter provided. Each person
so converting shares of Series B Preferred Stock shall be entitled to all declared but unpaid dividends up to the time of the 

  
 -7- 

 
conversion. Such dividends shall be paid to each such person within thirty (30) days of the date of conversion. 

(b) Automatic Conversion. Each share of Preferred Stock shall automatically be converted into shares of Common Stock at the then
effective applicable Conversion Price upon: 
 (i) the closing of a firm commitment underwritten public offering pursuant to an effective
registration statement under the Securities Act of 1933, as amended (the “Securities Act”), resulting in at least $50,000,000 of gross proceeds, net of the underwriting discount and commissions, to the Corporation, and covering the
offer and sale of Common Stock for the account of the Corporation to the public at a price of at least $4.00 per share, subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization
affecting such shares, provided such offering has been approved by the Corporation’s Board of Directors, including the Requisite Preferred Directors (the term “Requisite Preferred Directors” shall mean (i) all of the
Preferred Directors at such times as there are four (4) or fewer Preferred Directors sitting on the Board of Directors, (ii) four (4) of the Preferred Directors at such times as there are five (5) Preferred Directors sitting on
the Board of Directors, and (iii) a majority of the Preferred Directors at such times as there are six (6) or more Preferred Directors. The term “Preferred Directors” shall have the meaning ascribed thereto in that certain
Fourth Amended and Restated Voting Agreement by and among the Corporation and certain of its stockholders, as it may hereafter be amended) (a “Qualified IPO”); or 

(ii) the written consent of holders in interest of more than seventy percent (70%) in voting power (as determined pursuant to
Section 3.4 hereof) of the then-outstanding shares of Preferred Stock. 
 The person(s) entitled to receive Common Stock issuable upon
a conversion of Preferred Stock hereunder shall not be deemed to have converted the Preferred Stock until immediately prior to the closing of such offering or the receipt by the Corporation of such consent. Each person who holds of record Preferred
Stock immediately prior to an automatic conversion shall be entitled to all declared but unpaid dividends up to the time of the automatic conversion. Such dividends shall be paid to all such holders within thirty (30) days of the automatic
conversion. 
 (c) Mechanics of Conversion. 

(i) No fractional shares of Common Stock shall be issued upon conversion of Preferred Stock. In lieu of any fractional shares to which the
holder would otherwise be entitled, the Corporation shall pay cash equal to such fraction multiplied by the then effective applicable Conversion Price. Before any holder of Preferred Stock shall be entitled to convert the same into full shares of
Common Stock, such holder shall surrender the certificate or certificates therefor, duly endorsed, at the office of the Corporation or of any transfer agent for the Preferred Stock, and shall give written notice to the Corporation at such office
that such holder elects to convert the same and shall state therein his name or the name or names of his nominees in which such holder wishes the certificate or certificates for shares of Common Stock to be issued, together with the applicable
federal taxpayer identification number. The Corporation shall, as soon as practicable thereafter, issue and deliver at such office to such holder of Preferred Stock, or to his 

  
 -8- 

 
nominee or nominees, a certificate or certificates for the number of shares of Common Stock to which he shall be entitled, together with cash in lieu of any fraction of a share. Subject to
Section 3.3(b) above, such conversion shall be deemed to have been made immediately prior to the close of business on the date of such surrender of the shares of Preferred Stock to be converted, and the person or persons entitled to receive the
shares of Common Stock issuable upon conversion shall be treated for all purposes as the record holder or holders of such shares of Common Stock on such date. 

(ii) If the conversion is in connection with an underwritten offering of securities pursuant to the Securities Act, the conversion may, at
the option of any holder tendering shares of Preferred Stock for conversion, be conditioned upon the closing with the underwriters of the sale of securities pursuant to such offering, in which event the person(s) entitled to receive the Common Stock
upon conversion of the Preferred Stock shall not be deemed to have converted such Preferred Stock until immediately prior to the closing of such sale of securities. 

(d) Adjustments to Conversion Price for Diluting Issues: 

(i) Special Definitions. For purposes of Section 3.3(d), the following definitions shall apply: 

(1) “Option” shall mean rights, options or warrants to subscribe for, purchase or otherwise acquire either Common Stock or
Convertible Securities. 
 (2) “Original Issue Date” shall mean the date on which the first share of Series B
Preferred Stock was issued. 
 (3) “Convertible Securities” shall mean any evidences of indebtedness, shares or other
securities directly or indirectly convertible into or exchangeable for Common Stock, but excluding Options. 
 (4) “Additional
Shares of Common Stock” shall mean all shares of Common Stock issued (or, pursuant to Section 3.3(d)(iii), deemed to be issued) by the Corporation after the Original Issue Date, other than the following shares of Common Stock, and
shares of Common Stock deemed issued pursuant to the following Options and Convertible Securities: 
 (A) shares of Common Stock issued
upon conversion of shares of Preferred Stock or shares of Common Stock issued by way of a dividend or distribution on shares of Preferred Stock; 

(B) up to 11,792,500 shares of Common Stock or Options (in each case, subject to appropriate adjustment in the event of any stock dividend,
stock split, combination or other similar recapitalization affecting such shares) issued to officers, directors or employees of, or consultants or advisors to, the Corporation or any of its subsidiaries pursuant to any stock purchase or option plan
or other employee or director stock incentive or compensation agreement or program (each, a “Plan”) approved by the Board of Directors, including the Requisite Preferred Directors; 

  
 -9- 

 (C) shares of Common Stock issued to officers, directors or employees of, or consultants or
advisors to, the Corporation in connection with services to the Corporation up to a number of shares that is equal to the aggregate number of shares (i) repurchased by the Corporation pursuant to the provisions of non-Plan restricted stock or
similar agreements with the Corporation outstanding as of the date this Amended and Restated Certificate of Incorporation is filed with the Secretary of State of Delaware, and (ii) subject to non-Plan stock options, warrants or similar rights
that expired without being exercised, subject in each case to such issuances being approved by the Board of Directors including the Requisite Preferred Directors; 

(D) shares of Common Stock, Options or Convertible Securities issued to the Massachusetts Institute of Technology (“MIT”)
and certain other persons designated by MIT pursuant to that certain Exclusive Patent License Agreement entered into by the Corporation and MIT on April 28, 2008, as it may be amended from time to time, as consideration for an exclusive license
to certain patents described therein; 
 (E) shares of Common Stock, Options or Convertible Securities issued in consideration for the
acquisition or licensing of technology or a corporate partnership transaction, if approved by the Board of Directors, including the Requisite Preferred Directors; 

(F) shares of Common Stock, Options or Convertible Securities issued pursuant to debt financing, equipment leasing or real property leasing
transactions, if approved by the Board of Directors, including the Requisite Preferred Directors; 
 (G) shares of Common Stock, Options or
Convertible Securities issued to the public pursuant to a registration statement filed with the Securities and Exchange Commission; 
 (H)
shares of Common Stock or Convertible Securities actually issued upon the exercise of Options or shares of Common Stock actually issued upon the conversion or exchange of Convertible Securities, in each case provided such issuance is pursuant to the
terms of such Option or Convertible Security; 
 (I) shares of Common Stock, Options or Convertible Securities issued to suppliers or third
party service providers in connection with the provision of goods or services pursuant to transactions approved by the Board of Directors, including the Requisite Preferred Directors; 

(J) shares of Common Stock, Options or Convertible Securities issued pursuant to the acquisition of another corporation by the Corporation by
merger, purchase of substantially all of the assets or other reorganization or to a joint venture agreement, provided that such issuances are approved by the Board of Directors, including the Requisite Preferred Directors; 

(K) shares of Common Stock, Options or Convertible Securities issued or issuable hereafter that are expressly approved as being excluded from
the 

  
 -10- 

 
definition of “Additional Shares of Common Stock” under this Section 3.3(d)(i)(4)(K) by the Corporation’s Board of Directors, including the Requisite Preferred Directors and
seventy percent (70%) of the then outstanding shares of Preferred Stock voting together as a single class; and 
 (L) shares of Common
Stock issued pursuant to the Amended and Restated Series B Convertible Preferred Stock Purchase Agreement dated on or about September 9, 2014, by and among the Corporation and certain Purchasers, Founder Holders and Preferred Holders party
thereto, as amended from time to time; 
 (ii) No Adjustment of Conversion Price. 

(1) No adjustment in the Conversion Price of the Seed Preferred Stock shall be made due to the issuance of Additional Shares of Common Stock
(i) unless the consideration per share (determined pursuant to Section 3.3(d)(v) hereof) for such Additional Shares of Common Stock issued or deemed to be issued by the Corporation is less than the Conversion Price of the Seed Preferred
Stock in effect on the date of, and immediately prior to, the issue of such Additional Shares of Common Stock or (ii) if the Corporation receives written notice from the holders of at least seventy percent (70%) of the then outstanding
shares of Seed Preferred Stock agreeing that no such adjustment shall be made due to such issuance. 
 (2) No adjustment in the Conversion
Price of the Series A Preferred Stock shall be made due to the issuance of Additional Shares of Common Stock (i) unless the consideration per share (determined pursuant to Section 3.3(d)(v) hereof) for such Additional Shares of Common
Stock issued or deemed to be issued by the Corporation is less than the Conversion Price of the Series A Preferred Stock in effect on the date of, and immediately prior to, the issue of such Additional Shares of Common Stock or (ii) if the
Corporation receives written notice from the holders of at least seventy percent (70%) of the then outstanding shares of Series A Preferred Stock agreeing that no such adjustment shall be made due to such issuance. 

(3) No adjustment in the Conversion Price of the Series B Preferred Stock shall be made due to the issuance of Additional Shares of
Common Stock (i) unless the consideration per share (determined pursuant to Section 3.3(d)(v) hereof) for such Additional Shares of Common Stock issued or deemed to be issued by the Corporation is less than the Conversion Price of the
Series B Preferred Stock in effect on the date of, and immediately prior to, the issue of such Additional Shares of Common Stock or (ii) if the Corporation receives written notice from the holders of more than seventy percent (70%) of
the then outstanding shares of Series B Preferred Stock agreeing that no such adjustment shall be made due to such issuance. 
 (iii)
Deemed Issue of Additional Shares of Common Stock. 
 (1) Options and Convertible Securities. In the event the Corporation at
any time or from time to time after the Original Issue Date shall issue any Options or Convertible Securities or shall fix a record date for the determination of holders of any class of securities entitled to receive any such Options or Convertible
Securities, then the maximum number of shares (as set forth in the instrument relating thereto without regard to any provisions contained therein for a subsequent adjustment of such number) of Common Stock issuable upon the exercise of

  
 -11- 

 
such Options or, in the case of Convertible Securities and Options therefor, the conversion or exchange of such Convertible Securities, shall be deemed to be Additional Shares of Common Stock
issued as of the time of such issue or, in case such a record date shall have been fixed, as of the close of business on such record date, provided that Additional Shares of Common Stock shall not be deemed to have been issued if
(i) such shares of Common Stock are excluded from the definition of Additional Shares of Common Stock set forth in Section 3.3(d)(i)(4) or (ii) the consideration per share (determined pursuant to Section 3.3(d)(v)) of such
Additional Shares of Common Stock is not less than the Conversion Price of the applicable series of Preferred Stock in effect on the date of and immediately prior to such issue, or such record date, as the case may be; and provided,
however, that in any such case in which Additional Shares of Common Stock are deemed to be issued: 
 (A) no further adjustment in
the Conversion Price of the applicable series of Preferred Stock shall be made upon the subsequent issue of Convertible Securities or shares of Common Stock upon the exercise of such Options or conversion or exchange of such Convertible Securities;

 (B) if such Options or Convertible Securities by their terms provide, with the passage of time or otherwise, for any increase in the
consideration payable to the Corporation, or decrease in the number of shares of Common Stock issuable, upon the exercise, conversion or exchange thereof, the Conversion Price of the applicable series of Preferred Stock computed upon the original
issue thereof (or upon the occurrence of a record date with respect thereto), and any subsequent adjustments based thereon, shall, upon any such increase or decrease becoming effective, be recomputed to reflect such increase or decrease insofar as
it affects such Options or the rights of conversion or exchange under such Convertible Securities (provided, however, that no such adjustment of the Conversion Price shall affect Common Stock previously issued upon conversion of the
applicable series of Preferred Stock); 
 (C) upon the expiration of any such Options or any rights of conversion or exchange under such
Convertible Securities which shall not have been exercised, the Conversion Price of the applicable series of Preferred Stock computed upon the original issue thereof (or upon the occurrence of a record date with respect thereto) and any subsequent
adjustments based thereon shall, upon such expiration, be recomputed as if: 
 (i) in the case of Convertible Securities or Options for
Common Stock, the only Additional Shares of Common Stock issued were the shares of Common Stock, if any, actually issued upon the exercise of such Options or the conversion or exchange of such Convertible Securities and the consideration received
therefor was the consideration actually received by the Corporation for the issue of all such Options, whether or not exercised, plus the consideration actually received by the Corporation upon such exercise, or for the issue of all such Convertible
Securities which were actually converted or exchanged, plus the additional consideration, if any, actually received by the Corporation upon such conversion or exchange, and 

(ii) in the case of Options for Convertible Securities, only the Convertible Securities, if any, actually issued upon the exercise thereof
were issued at the time of issue of such Options, and the consideration received by the Corporation for the Additional 

  
 -12- 

 
Shares of Common Stock deemed to have been then issued was the consideration actually received by the Corporation for the issue of all such Options, whether or not exercised, plus the
consideration deemed to have been received by the Corporation (determined pursuant to Section 3.3(d)(v)) upon the issue of the Convertible Securities with respect to which such Options were actually exercised; 

(D) no readjustment pursuant to clause (B) or (C) above shall have the effect of increasing the Conversion Price of any series of
Preferred Stock to an amount which exceeds the lower of (i) the Conversion Price of such series of Preferred Stock on the original adjustment date, or (ii) the Conversion Price of such series of Preferred Stock that would have resulted
from any other issuance of Additional Shares of Common Stock between the original adjustment date and such readjustment date; 
 (E) in the
case of any Options which expire by their terms not more than thirty (30) days after the date of issue thereof, no adjustment of the Conversion Price of the applicable series Preferred Stock shall be made until the expiration or exercise of all
such Options, whereupon such adjustment shall be made in the same manner provided in clause (C) above; and 
 (F) if such record date
shall have been fixed and such Options or Convertible Securities are not issued on the date fixed therefor, the adjustment previously made in the Conversion Price of the applicable series of Preferred Stock which became effective on such record date
shall be canceled as of the close of business on such record date, and thereafter the Conversion Price of the applicable series of Preferred Stock shall be adjusted pursuant to this Section 3.3(d)(iii) as of the actual date of their issuance.

 (2) Stock Dividends, Stock Distributions and Subdivisions. In the event the Corporation at any time or from time to time after
the Original Issue Date shall declare or pay any dividend or make any other distribution on the Common Stock payable in Common Stock or in any right to acquire Common Stock for no consideration, or effect a subdivision of the outstanding shares of
Common Stock (by reclassification or otherwise than by payment of a dividend in Common Stock), then and in any such event, Additional Shares of Common Stock shall not be deemed to have been issued, but the Conversion Prices of the Preferred Stock
shall be adjusted in accordance with Section 3.3(d)(vi). 
 (iv) Adjustment of Conversion Price Upon Issuance of Additional Shares
of Common Stock. 
 (1) In the event the Corporation shall issue Additional Shares of Common Stock (including Additional Shares of
Common Stock deemed to be issued pursuant to Section 3.3(d)(iii)) without consideration or for a consideration per share less than the Seed Conversion Price in effect on the date of and immediately prior to such issue, then and in such event,
the Seed Conversion Price shall be reduced, concurrently with such issue in order to increase the number of shares of Common Stock into which the Seed Preferred Stock is convertible, to a price (calculated to the nearest cent) determined by dividing
(A) (i) the Seed Conversion Price in effect immediately prior to such issue multiplied by the number of shares of Common Stock outstanding immediately prior to such issue (including shares of Common Stock issuable upon conversion of any

  
 -13- 

 
outstanding Options, Convertible Securities and shares of Preferred Stock), plus (ii) the aggregate consideration received by the Corporation for the total number of Additional Shares of
Common Stock so issued, by (B) (i) the number of shares of Common Stock outstanding immediately prior to such issue (including shares of Common Stock issuable upon conversion of any outstanding Options, Convertible Securities and shares of
Preferred Stock), plus (ii) the total number of such Additional Shares of Common Stock so issued, provided that the Seed Conversion Price shall not be so reduced at such time if the amount of such reduction would be an amount less than
$0.01, but any such amount shall be carried forward and any reduction with respect thereto shall be made at the time of and together with any subsequent reduction which, together with such amount and any other amount or amounts so carried forward,
shall aggregate $0.01 or more. 
 (2) In the event the Corporation shall issue Additional Shares of Common Stock (including Additional
Shares of Common Stock deemed to be issued pursuant to Section 3.3(d)(iii)) without consideration or for a consideration per share less than the Series A Conversion Price in effect on the date of and immediately prior to such issue, then
and in such event, the Series A Conversion Price shall be reduced, concurrently with such issue in order to increase the number of shares of Common Stock into which the Series A Preferred Stock is convertible, to a price (calculated to the
nearest cent) determined by dividing (A) (i) the Series A Conversion Price in effect immediately prior to such issue multiplied by the number of shares of Common Stock outstanding immediately prior to such issue (including shares of
Common Stock issuable upon conversion of any outstanding Options, Convertible Securities and shares of Preferred Stock), plus (ii) the aggregate consideration received by the Corporation for the total number of Additional Shares of Common Stock
so issued, by (B) (i) the number of shares of Common Stock outstanding immediately prior to such issue (including shares of Common Stock issuable upon conversion of any outstanding Options, Convertible Securities and shares of Preferred
Stock), plus (ii) the total number of such Additional Shares of Common Stock so issued, provided that the Series A Conversion Price shall not be so reduced at such time if the amount of such reduction would be an amount less than
$0.01, but any such amount shall be carried forward and any reduction with respect thereto shall be made at the time of and together with any subsequent reduction which, together with such amount and any other amount or amounts so carried forward,
shall aggregate $0.01 or more. 
 (3) In the event the Corporation shall issue Additional Shares of Common Stock (including Additional
Shares of Common Stock deemed to be issued pursuant to Section 3.3(d)(iii)) without consideration or for a consideration per share less than the Series B Conversion Price in effect on the date of and immediately prior to such issue, then
and in such event, the Series B Conversion Price shall be reduced, concurrently with such issue in order to increase the number of shares of Common Stock into which the Series B Preferred Stock is convertible, to a price (calculated to the
nearest cent) determined by dividing (A) (i) the Series B Conversion Price in effect immediately prior to such issue multiplied by the number of shares of Common Stock outstanding immediately prior to such issue (including shares of
Common Stock issuable upon conversion of any outstanding Options, Convertible Securities and shares of Preferred Stock), plus (ii) the aggregate consideration received by the Corporation for the total number of Additional Shares of Common Stock
so issued, by (B) (i) the number of shares of Common Stock outstanding immediately prior to such issue (including shares of Common Stock issuable upon conversion of any outstanding Options, Convertible Securities and shares of Preferred
Stock), plus (ii) the total number of such Additional Shares of Common Stock so issued, provided that the Series B Conversion Price shall not be so 

  
 -14- 

 
reduced at such time if the amount of such reduction would be an amount less than $0.01, but any such amount shall be carried forward and any reduction with respect thereto shall be made at the
time of and together with any subsequent reduction which, together with such amount and any other amount or amounts so carried forward, shall aggregate $0.01 or more. 

(v) Determination of Consideration. For purposes of this Section 3.3(d), the consideration received by the Corporation for the
issue of any Additional Shares of Common Stock shall be computed as follows: 
 (1) Cash and Property. Such consideration shall:

 (A) insofar as it consists of cash, be computed at the aggregate amount of cash received by the Corporation excluding amounts paid or
payable for accrued interest or accrued dividends; 
 (B) insofar as it consists of property other than cash, be computed at the fair value
thereof at the time of such issue, as determined in good faith by the Board of Directors; and 
 (C) in the event Additional Shares of
Common Stock are issued together with other shares or securities or other assets of the Corporation for consideration which covers both, be the proportion of such consideration so received, computed as provided in clauses (A) and
(B) above, as determined in good faith by the Board of Directors. 
 (2) Options and Convertible Securities. The aggregate
consideration received by the Corporation for Additional Shares of Common Stock deemed to have been issued pursuant to Section 3.3(d)(iii)(1), relating to Options and Convertible Securities, shall be determined by computing the total amount, if
any, received or receivable by the Corporation as consideration for the issue of such Options or Convertible Securities, plus the minimum aggregate amount of additional consideration (as set forth in the instruments relating thereto, without regard
to any provision contained therein for a subsequent adjustment of such consideration until such subsequent adjustment occurs) payable to the Corporation upon the exercise of such Options or the conversion or exchange of such Convertible Securities
or in the case of Options for Convertible Securities, the exercise of such Options for Convertible Securities and the conversion or exchange of such Convertible Securities. The total number of Additional Shares of Common Stock so issued shall be
determined by calculating the maximum number of shares of Common Stock (as set forth in the instruments relating thereto, without regard to any provision contained therein for a subsequent adjustment of such number until such subsequent adjustment
occurs) issuable upon the exercise of such Options or the conversion or exchange of such Convertible Securities. 
 (vi) Adjustment for
Dividends, Distributions, Subdivisions Combinations or Consolidation of Common Stock. 
 (1) Stock Dividends, Distributions or
Subdivisions. In the event the Corporation at any time, or from time to time, shall declare or pay any dividend or make any other distribution on the Common Stock payable in Common Stock, or effect a subdivision of the

  
 -15- 

 
outstanding shares of Common Stock (by reclassification or otherwise than by payment of a dividend in Common Stock), the Conversion Price for each series of Preferred Stock in effect immediately
prior to such stock dividend, stock distribution or subdivision shall, concurrently with the effectiveness of such stock dividend, stock distribution or subdivision, be proportionately decreased. In the event that this Corporation shall declare or
pay, without consideration, any dividend on the Common Stock payable in any right to acquire Common Stock for no consideration, then the Corporation shall be deemed to have made a dividend payable in Common Stock in an amount of shares equal to the
maximum number of shares issuable upon exercise of such rights to acquire Common Stock. 
 (2) Combinations or Consolidations. In
the event the outstanding shares of Common Stock shall be combined or consolidated, by reclassification or otherwise, into a lesser number of shares of Common Stock, the Conversion Price for each series of Preferred Stock in effect immediately prior
to such combination or consolidation shall concurrently with the effectiveness of such combination or consolidation, be proportionately increased. 

(vii) Adjustment for Merger or Reorganization. Subject to the last sentence of this Section 3.3(d)(vii) and Section 3.2, in
case of any consolidation or merger of the Corporation with or into another corporation or the conveyance of all or substantially all of the assets of the Corporation to another corporation in which the holders of Common Stock will be entitled to
receive shares of stock, other securities or property, each share of Preferred Stock shall thereafter be convertible into the number of shares of stock or other securities or property to which a holder of the number of shares of Common Stock of the
Corporation deliverable upon conversion of such share of Preferred Stock would have been entitled upon such consolidation, merger or conveyance. In any such case, appropriate adjustment (as determined by the Board of Directors) shall be made in the
application of these provisions set forth with respect to the rights and interest thereafter of the holders of Preferred Stock, to the end that these provisions (including provisions with respect to changes in and other adjustments of the Conversion
Prices) shall thereafter be applicable, as nearly as reasonably may be, in relation to any shares of stock or other property thereafter deliverable upon the conversion of the Preferred Stock. In the event that such merger or consolidation of the
Corporation or the sale of all or substantially all its assets and properties shall also be subject to the provisions of Section 3.2 above, the holders of more than seventy percent (70%) in voting power (as determined pursuant to
Section 3.4 hereof) of the then-outstanding shares of Preferred Stock may elect to obtain the treatment of all outstanding shares of Preferred Stock under this Section 3.3(d)(vii) in lieu of that described in Section 3.2, notice of
which election shall be submitted in writing to the Corporation at its principal offices no later than fifteen (15) days before the effective date of such event. 

(e) No Impairment. The Corporation will not, by amendment of this Amended and Restated Certificate of Incorporation or through any
reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms to be observed or performed hereunder by the
Corporation without the written consent of the holders of more than seventy percent (70%) in voting power (as determined pursuant to Section 3.4 hereof) of the then-outstanding shares of Preferred Stock, but will at all times in good faith
assist in the carrying out of all the provisions of this Section 3.3 and in the taking of all such action as may be necessary or 

  
 -16- 

 
appropriate in order to protect the Conversion Rights of the holders of Preferred Stock against impairment. 

(f) Certificate as to Adjustments. Upon the occurrence of each adjustment or readjustment of any Conversion Price pursuant to this
Section 3.3, the Corporation at its expense shall promptly compute such adjustment or readjustment in accordance with these terms and furnish to each holder of Preferred Stock a certificate setting forth such adjustment, readjustment or
conversion and showing in detail the facts upon which such adjustment, readjustment or conversion is based, provided that the failure to promptly provide such notice shall not affect the effectiveness of such adjustment, or readjustment or
conversion. The Corporation shall, upon the written request at any time of any holder of Preferred Stock, furnish or cause to be furnished to such holder a like certificate setting forth (i) such adjustments and readjustments, (ii) the
Seed Conversion Price, the Series A Conversion Price and the Series B Conversion Price, and (iii) the number of shares of Common Stock and the amount, if any, of other property which at the time would be received upon the conversion
of Seed Preferred Stock, Series A Preferred Stock or Series B Preferred Stock, as the case may be. 
 (g) Notices of Record
Date. In the event of (i) any taking by Corporation of a record date of the holders of any class of securities for the purpose of determining the holders thereof who are entitled to receive any dividend (other than a cash dividend which is
the same as cash dividends paid in previous quarters) or other distribution, or (ii) any capital reorganization of the Corporation, any reclassification or recapitalization of the capital stock of the Corporation, any merger or consolidation of
the Corporation, and any transfer of all or substantially all of the assets of the Corporation to any other corporation, or any other entity or person, or any voluntary or involuntary dissolution, liquidation or winding up of the Corporation, the
Corporation shall mail to each holder of Preferred Stock at least 15 days prior to the record date specified therein, a notice specifying (A) the date on which any such record is to be taken for the purpose of such dividend or distribution and
a description of such dividend or distribution, (B) the date on which any such reorganization, reclassification, transfer, consolidation, merger, dissolution, liquidation or winding up is expected to become effective, and (C) the time, if
any, that is to be fixed, as to when the holders of record of Common Stock (or other securities) shall be entitled to exchange their shares of Common Stock (or other securities) for securities or other property deliverable upon such reorganization,
reclassification, transfer, consolidation, merger, dissolution, liquidation or winding up. 
 (h) Common Stock Reserved. The
Corporation shall reserve and keep available out of its authorized but unissued Common Stock, solely for the purpose of effecting the conversion of the shares of the Preferred Stock, such number of shares of Common Stock as shall from time to time
be sufficient to effect conversion of the Preferred Stock. 
 3.4 Voting Rights. On any matter presented to the stockholders of the
Corporation for their action or consideration at any meeting of stockholders of the Corporation (or by written consent of stockholders in lieu of meeting), (a) each holder of outstanding shares of Seed Preferred Stock or Series A Preferred
Stock shall be entitled to cast the number of votes equal to the number of whole shares of Common Stock into which the shares of Seed Preferred Stock or Series A Preferred Stock, as the case may be, held by such holder are convertible as of the
record date for determining 

  
 -17- 

 
stockholders entitled to vote on such matter and (b) each holder of outstanding shares of Series B Preferred Stock shall be entitled to cast the number of votes equal 1.25 multiplied by
the number of whole shares of Common Stock into which the shares of Series B Preferred Stock held by such holder are convertible as of the record date for determining stockholders entitled to vote on such matter. Except as otherwise required by
law or by the other provisions of this Amended and Restated Certificate of Incorporation, holders of Common Stock, Seed Preferred Stock, Series A Preferred Stock and Series B Preferred Stock shall vote together, as though a single class.

 3.5 Dividend Right. 

(a) The Corporation shall not declare, pay or set aside any dividends on shares of any other class or series of capital stock of the
Corporation (other than dividends on shares of Common Stock payable in shares of Common Stock) unless (in addition to the obtaining of any consents required elsewhere in the Certificate of Incorporation) the holders of the Series B Preferred
Stock then outstanding shall first receive, or simultaneously receive, a dividend on each outstanding share of Series B Preferred Stock in an amount at least equal to (i) in the case of a dividend on Common Stock or any class or series
that is convertible into Common Stock, that dividend per share of Series B Preferred Stock as would equal the product of (A) the dividend payable on each share of such class or series determined, if applicable, as if all shares of such
class or series had been converted into Common Stock and (B) the number of shares of Common Stock issuable upon conversion of a share of Series B Preferred Stock, in each case calculated on the record date for determination of holders
entitled to receive such dividend or (ii) in the case of a dividend on any class or series that is not convertible into Common Stock, at a rate per share of Series B Preferred Stock determined by (A) dividing the amount of the
dividend payable on each share of such class or series of capital stock by the original issuance price of such class or series of capital stock (subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other
similar recapitalization with respect to such class or series) and (B) multiplying such fraction by an amount equal to the Series B Original Issue Price; provided that, if the Corporation declares, pays or sets aside, on the same
date, a dividend on shares of more than one class or series of capital stock of the Corporation, the dividend payable to the holders of Series B Preferred Stock pursuant to this Section 3.5(a) shall be calculated based upon the dividend on
the class or series of capital stock that would result in the highest Series B Preferred Stock dividend. 
 (b) The Corporation shall
not declare, pay or set aside any dividends on shares of any other class or series of capital stock of the Corporation (other than (i) dividends on shares of Series B Preferred Stock, and (ii) dividends on shares of Common Stock
payable in shares of Common Stock) unless (in addition to the obtaining of any consents required elsewhere in this Amended and Restated Certificate of Incorporation) the holders of the Series A Preferred Stock and Seed Preferred Stock then
outstanding shall first receive, or simultaneously receive, a dividend on each outstanding share of Series A Preferred Stock or Seed Preferred Stock, as applicable, in an amount at least equal to (i) in the case of a dividend on Common
Stock or any class or series that is convertible into Common Stock, that dividend per share of Series A Preferred Stock or Seed Preferred Stock, as applicable, as would equal the product of (A) the dividend payable on each share of such
class or series determined, if applicable, as if all shares of such class or series had been converted into Common Stock and (B) the number of shares of Common Stock issuable upon conversion of a share of Series A Preferred Stock or Seed
Preferred Stock, as applicable, in each 

  
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case calculated on the record date for determination of holders entitled to receive such dividend or (ii) in the case of a dividend on any class or series that is not convertible into Common
Stock, at a rate per share of Series A Preferred Stock or Seed Preferred Stock, as applicable, determined by (A) dividing the amount of the dividend payable on each share of such class or series of capital stock by the original issuance
price of such class or series of capital stock (subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to such class or series) and (B) multiplying such
fraction by an amount equal to the Series A Original Issue Price, in the case of the Series A Preferred Stock, and the Seed Original Issue Price, in the case of the Seed Preferred Stock; provided that, if the Corporation declares,
pays or sets aside, on the same date, a dividend on shares of more than one class or series of capital stock of the Corporation, the dividend payable to the holders of Series A Preferred Stock and Seed Preferred Stock pursuant to this
Section 3.5(b) shall be calculated based upon the dividend on the class or series of capital stock that would result in the highest Series A Preferred Stock dividend in the case of the Series A Preferred Stock, and the highest Seed
Preferred Stock dividend in the case of the Seed Preferred Stock. 
 (c) Any declared and unpaid dividend shall be payable on liquidation
and conversion in accordance with Sections 3.2 and 3.3. 
 (d) In the event the Corporation shall declare a distribution on the Common
Stock payable in securities of other persons, evidences of indebtedness issued by the Corporation or other persons, assets (excluding cash dividends) or options or rights to purchase any such securities or evidences of indebtedness, then, in each
such case the holders of the Preferred Stock shall be entitled to a proportionate share of any such distribution as though the holders of the Preferred Stock were the holders of the number of shares of Common Stock of the Corporation into which
their respective shares of Preferred Stock were convertible as of the record date fixed for the determination of the holders of Common Stock of the Corporation entitled to receive such distribution. 

3.6 Preferred Stock Protection Provisions. In addition to Section 3.4 and any vote which the Preferred Stock may have under the
General Corporation Law of Delaware, so long as at least fifteen percent (15%) of the shares of Preferred Stock originally issued shall be outstanding, the Corporation shall not (whether by amendment, merger or otherwise), without first
obtaining the affirmative vote or written consent of more than seventy percent (70%) in voting power (as determined pursuant to Section 3.4 hereof) of the then-outstanding shares of Preferred Stock: 

(a) amend or repeal any provision of, or add any provision to, this Amended and Restated Certificate of Incorporation or By-laws of the
Corporation (the “By-laws”); 
 (b) effect a change of control, liquidation, merger, reincorporation, recapitalization, or
sale or other transfer of a substantial part of the Corporation’s assets other than in the ordinary course of business; 
 (c) create
any class or series of stock having rights of redemption, liquidation preference, voting or dividend rights on parity with or having preference over any series of Preferred Stock; 

  
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 (d) effect any acquisition of (i) the capital stock of another entity which results in the
consolidation of that entity into the results of operations of the Corporation or (ii) all or substantially all of the assets of another entity; 

(e) incur any indebtedness for borrowed money, in a single or related series of transactions, in an amount in excess of $500,000; 

(f) create or adopt a new plan for the grant of stock options or the issuance of restricted stock to employees, consultants, directors or
officers of the Corporation or increase the number of shares available under any such existing plan; 
 (g) pay or declare any dividend or
distribution on any shares of the Corporation’s capital stock (except dividends payable solely in shares of Common Stock), or apply any of the Corporation’s assets to the redemption or repurchase of the Corporation’s capital stock
(except for (i) acquisitions of Common Stock by the Corporation pursuant to agreements which permit the Corporation to repurchase such shares at cost (or the lesser of cost or fair market value) upon termination of services by an employee,
director, officer or consultant to the Corporation or acquisitions of Common Stock pursuant to the Corporation’s exercise of its right of first refusal with respect to such shares, (ii) redemptions or repurchases of Series A Preferred
Stock or Common Stock on the terms and in the manner set forth in that certain letter agreement by and between the Corporation and the Bill & Melinda Gates Foundation, dated on or about November 7, 2013 (as amended from time to time),
or (iii) as otherwise expressly authorized herein); 
 (h) increase or decrease the authorized number of directors of the Corporation;

 (i) enter into, agree to enter into or execute any transaction with any officer, director or affiliate (as such term is defined in the
regulations promulgated under the Securities Act) of the Corporation unless approved by a disinterested majority of the Board of Directors. 

3.7 Converted or Otherwise Acquired Shares. Any share of Preferred Stock that is converted under Section 3.3 or otherwise acquired
by the Corporation will be canceled and will not be reissued, sold or transferred. 
 3.8 Residual Rights. All rights accruing to the
outstanding shares of the Corporation not expressly provided for to the contrary shall be vested in the Common Stock. 
 3.9 Waiver.
Any of the rights of the holders of Seed Preferred Stock, Series A Preferred Stock and Series B Preferred Stock set forth herein may be waived by the affirmative consent or vote of the holders of more than seventy percent (70%) in
voting power (as determined pursuant to Section 3.4 hereof) of the then-outstanding shares of Seed Preferred Stock, Series A Preferred Stock and Series B Preferred Stock, provided such waiver by its terms is equally applicable to the
holders of Seed Preferred Stock, Series A Preferred Stock and Series B Preferred Stock. Any of the rights of the holders of Seed Preferred Stock set forth herein may be waived (in a manner that does not apply to the holders of
Series A Preferred Stock or Series B Preferred Stock) by the affirmative consent or vote of the holders of at least seventy percent (70%) of the shares of Seed Preferred Stock then outstanding. Any of the rights of the holders of
Series A Preferred Stock set forth herein may be 

  
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waived (in a manner that does not apply to the holders of Seed Preferred Stock or Series B Preferred Stock) by the affirmative consent or vote of the holders of at least seventy percent
(70%) of the shares of Series A Preferred Stock then outstanding. Any of the rights of the holders of Series B Preferred Stock set forth herein may be waived (in a manner that does not apply to the holders of Seed Preferred Stock or
Series A Preferred Stock) by the affirmative consent or vote of the holders of more than seventy percent (70%) of the shares of Series B Preferred Stock then outstanding. 

FIFTH: The election of directors need not be by written ballot unless the By-laws shall so require. 

SIXTH: In furtherance of and not in limitation of powers conferred by statute, it is further provided: that (1) the
business and affairs of the Corporation shall be managed by or under the direction of the Board of Directors; and (2) the Board of Directors is expressly authorized to adopt, amend, alter or repeal the By-Laws. 

SEVENTH: Except to the extent that the General Corporation Law of Delaware prohibits the elimination or limitation of liability of
directors for breaches of fiduciary duty, no director of the Corporation shall be personally liable to the Corporation or its stockholders for monetary damages for any breach of fiduciary duty as a director, notwithstanding any provision of law
imposing such liability. No amendment to or repeal of this provision shall apply to or have any effect on the liability or alleged liability of any director of the Corporation for or with respect to any acts or omissions of such director occurring
prior to such amendment. 
 EIGHTH: The Corporation shall, to the fullest extent permitted by Section 145 of the General
Corporation Law of Delaware, as amended from time to time, indemnify each person who was or is a party or is threatened to be made a party to any threatened, pending or completed action, suit or proceeding, whether civil, criminal, administrative or
investigative, by reason of the fact that he or she is or was, or has agreed to become, a director or officer of the Corporation, or is or was serving, or has agreed to serve, at the request of the Corporation, as a director, officer, partner,
employee or trustee of, or in a similar capacity with, another corporation, partnership, joint venture, trust or other enterprise (including any employee benefit plan) (all such persons being referred to hereafter as an
“Indemnitee”), or by reason of any action alleged to have been taken or omitted in such capacity, against all expenses (including attorneys’ fees), judgments, fines and amounts paid in settlement actually and reasonably
incurred by or on behalf of an Indemnitee in connection with such action, suit or proceeding and any appeal therefrom. 
 As a condition
precedent to an Indemnitee’s right to be indemnified, the Indemnitee must notify the Corporation in writing as soon as practicable of any action, suit, proceeding or investigation involving such Indemnitee for which indemnity will or could be
sought. With respect to any action, suit, proceeding or investigation of which the Corporation is so notified, the Corporation will be entitled to participate therein at its own expense and/or to assume the defense thereof at its own expense, with
legal counsel reasonably acceptable to the Indemnitee. 
 In the event that the Corporation does not assume the defense of any action, suit,
proceeding or investigation of which the Corporation receives notice under this Article, the Corporation shall pay in advance of the final disposition of such matter any expenses (including attorneys’ fees)

  
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incurred by an Indemnitee in defending a civil or criminal action, suit, proceeding or investigation or any appeal therefrom; provided, however, that the payment of such expenses
incurred by an Indemnitee in advance of the final disposition of such matter shall be made only upon receipt of an undertaking by or on behalf of the Indemnitee to repay all amounts so advanced in the event that it shall ultimately be determined
that the Indemnitee is not entitled to be indemnified by the Corporation as authorized in this Article, which undertaking shall be accepted without reference to the financial ability of the Indemnitee to make such repayment; and further
provided that no such advancement of expenses shall be made under this Article if it is determined that (i) the Indemnitee did not act in good faith and in a manner he reasonably believed to be in, or not opposed to, the best interests
of the Corporation, or (ii) with respect to any criminal action or proceeding, the Indemnitee had reasonable cause to believe his conduct was unlawful. 

The Corporation shall not indemnify an Indemnitee pursuant to this Article in connection with a proceeding (or part thereof) initiated by such
Indemnitee unless the initiation thereof was approved by the Board of Directors of the Corporation. In addition, the Corporation shall not indemnify an Indemnitee to the extent such Indemnitee is reimbursed from the proceeds of insurance, and in the
event the Corporation makes any indemnification payments to an Indemnitee and such Indemnitee is subsequently reimbursed from the proceeds of insurance, such Indemnitee shall promptly refund such indemnification payments to the Corporation to the
extent of such insurance reimbursement. 
 All determinations hereunder as to the entitlement of an Indemnitee to indemnification or
advancement of expenses shall be made in each instance (a) by a majority vote of the directors of the Corporation consisting of persons who are not at that time parties to the action, suit or proceeding in question (“disinterested
directors”), whether or not a quorum, (b) by a committee of disinterested directors designated by majority vote of disinterested directors, whether or not a quorum, (c) if there are no disinterested directors, or if the
disinterested directors so direct, by independent legal counsel (who may, to the extent permitted by law, be regular legal counsel to the Corporation) in a written opinion, or (d) by the stockholders of the Corporation. 

The rights provided in this Article (i) shall not be deemed exclusive of any other rights to which an Indemnitee may be entitled under
any law, agreement or vote of stockholders or disinterested directors or otherwise, and (ii) shall inure to the benefit of the heirs, executors and administrators of the Indemnitees. The Corporation may, to the extent authorized from time to
time by its Board of Directors, grant indemnification rights to other employees or agents of the Corporation or other persons serving the Corporation and such rights may be equivalent to, or greater or less than, those set forth in this Article.

 NINTH: The Corporation reserves the right to amend, alter, change or repeal any provision contained in this Amended and Restated
Certificate of Incorporation, in the manner now or hereafter prescribed by statute and this Amended and Restated Certificate of Incorporation, and all rights conferred upon stockholders herein are granted subject to this reservation. 

TENTH: The Corporation renounces, to the fullest extent permitted by law, any interest or expectancy of the Corporation in, or in being
offered an opportunity to participate in, any Excluded Opportunity. An “Excluded Opportunity” is any matter, transaction or interest that is presented to, 

  
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or acquired, created or developed by, or which otherwise comes into the possession of (i) any director of the Corporation who is not an employee of the Corporation or any of its
subsidiaries, or (ii) any holder of Preferred Stock or any partner, member, director, stockholder, employee or agent of any such holder, other than someone who is an employee of the Corporation or any of its subsidiaries (collectively,
“Covered Persons”), unless such matter, transaction or interest is presented to, or acquired, created or developed by, or otherwise comes into the possession of, a Covered Person expressly and solely in such Covered Person’s
capacity as a director of the Corporation. 
 3. That the foregoing amendment and restatement was approved by the holders of the requisite
number of shares of the Corporation in accordance with Section 228 of the General Corporation Law. 
 4. That this Amended and Restated
Certificate of Incorporation, which restates and integrates and further amends the provisions of the Corporation’s Certificate of Incorporation, as amended, has been duly adopted in accordance with Sections 242 and 245 of the General
Corporation law. 
 *************** 

  
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 IN WITNESS WHEREOF, this Amended and Restated Certificate of Incorporation has been duly
executed by a duly authorized officer of the Corporation on the          day of                     , 2014.

  

			
	  

	Name:	 	Brian Pereira
	Title:	 	President and Chief Executive Officer

 [Signature Page to Amended and Restated Certificate of Incorporation] 

 EXHIBIT B 

Form of Fourth Amended and Restated Voting Agreement, 

as amended by Amendment No. 1 thereto 

 FOURTH AMENDED AND RESTATED VOTING AGREEMENT 

This Fourth Amended and Restated Voting Agreement dated as of May 15, 2014 (this “Agreement”) is made by and among
Visterra, Inc., a Delaware corporation (the “Company”); each holder of the Company’s Seed Convertible Preferred Stock, $0.01 par value per share (the “Seed Preferred Stock”), Series A Convertible Preferred
Stock, $0.01 par value per share (the “Series A Preferred Stock”), and Series B Convertible Preferred Stock, $0.01 par value per share (the “Series B Preferred Stock” and, together with the Seed Preferred Stock and
the Series A Preferred Stock, the “Preferred Stock”), listed on Schedule A hereto (each individually, an “Investor” and collectively, the “Investors”); the holders of shares of the
Company’s Common Stock, $0.0001 par value per share (the “Common Stock”) listed on Schedule B hereto (individually, a “Founder” and collectively, the “Founders”); and the holders of
Common Stock listed on Schedule C hereto (individually a “Common Holder” and collectively, the “Common Holders”). 

WHEREAS, the Founders and Common Holders own shares of Common Stock. 

WHEREAS, the Company, certain of the Investors, the Common Holders and the Founders are parties to a Third Amended and Restated Voting
Agreement dated May 14, 2012, as amended by Amendment No. 1 thereto dated September 12, 2012 (as amended, the “Third Amended Agreement”). 

WHEREAS, concurrently with the execution of this Agreement, the Company and certain of the Investors are entering into a Series B Convertible
Preferred Stock Purchase Agreement (the “Series B Purchase Agreement”) providing for the sale by the Company of shares of Series B Preferred Stock. Capitalized terms not otherwise defined herein shall have the meanings given to them
in the Series B Purchase Agreement. 
 WHEREAS, in connection with the transactions contemplated by the Series B Purchase Agreement and to
induce certain of the Investors to purchase shares of Series B Preferred Stock pursuant to the Series B Purchase Agreement, the Company, the Investors, the Common Holders and the Founders have agreed to amend and restate the Third Amended Agreement
as set forth herein. 
 NOW, THEREFORE, in consideration of the premises and the mutual covenants set forth herein, the parties hereto
hereby agree as follows: 
 1. Voting of Shares. 

1.1. Generally. In any and all elections of directors of the Company (whether at a meeting or by written consent in lieu of a meeting),
each Stockholder shall vote or cause to be voted all Shares (as defined in Section 2) owned by him or it, or over which he or it has voting control, and otherwise use his or its respective best efforts, so as to: 

(a) fix the number of directors of the Company at seven (7); and 

(b) elect seven (7) directors, including (i) one director designated by Polaris Venture Partners V, L.P. or an Affiliated Entity
(as defined in Section 6.2), who shall initially be Kevin Bitterman (the “Polaris Director”); (ii) one director designated by Flagship, 

 
who shall initially be Edwin Kania (the “Flagship Director”), (iii) one director designated by Merck Sharp & Dohme Corp. (“Merck”) (the
“Merck Director,” and together with the Polaris Director and the Flagship Director, the “Preferred Directors”); (iv) one director who shall be the Chief Executive Officer of the Company then in office, who
shall initially be Brian Pereira (the “CEO Director”); (v) two directors designated by the holders of at least 70% of the Common Stock, who shall initially be Alan L. Crane and Ram Sasisekharan; and (vi) one outside
director who is not otherwise an affiliate of the Company, any member of the Company’s management, or any Investor, who shall be designated by the mutual agreement of the other directors (the “Independent Director”). 

1.2. Removal. Any director of the Company may be removed from the Board of Directors in the manner allowed by law and the Amended and
Restated Certificate of Incorporation of the Company (the “Restated Certificate”) and By-laws, but with respect to any director designated pursuant to Section 1.1(b) above, only upon the vote or written consent of the
stockholder or stockholders entitled to designate such director. Each successor of such removed director shall be designated by only those stockholders (or their successors) who designated such removed director, and such successor shall be elected
in the same manner as provided in Section 1.1(b). 
 1.3. Compensation Committee. Each Stockholder shall use all reasonable
efforts to cause each director of the Company nominated by such Stockholder to take such corporate actions as may be reasonably required to ensure that (i) the Board of Directors of the Company has at all times a compensation committee (the
“Compensation Committee”), (ii) at least one Preferred Director and the Independent Director, to the extent such directors are then serving on the Board, are appointed to the Compensation Committee and (iii) any Preferred
Director that wishes to serve on the Compensation Committee will be appointed to the Compensation Committee. All increases in executive compensation, executive bonuses and all option grants (including the vesting schedules with respect to such
option grants) shall be approved by either (a) the Compensation Committee or (b) the Board of Directors, including all of the Preferred Directors. 

1.4. Approval by the Preferred Directors. For purposes of the Restated Certificate, the Series B Purchase Agreement, this Agreement,
the By-laws, or any other agreement or instrument to which the Company is now or in the future becomes a party, references to any vote, consent, or approval required by or of the Preferred Directors shall mean the unanimous consent by and of all the
Preferred Directors. 
 1.5. No “Bad Actor” Designees. Each person with the right to designate or participate in the
designation of a director as specified above hereby represents and warrants to the Company that, to such person’s knowledge, none of the “bad actor” disqualifying events described in Rule 506(d)(1)(i)-(viii) promulgated under the
Securities Act of 1933, as amended (the “Securities Act”) (each, a “Disqualification Event”), is applicable to such person’s initial designee named above except, if applicable, for a Disqualification Event as
to which Rule 506(d)(2)(ii) or (iii) or (d)(3) is applicable. Any director designee to whom any Disqualification Event is applicable, except for a Disqualification Event as to which Rule 506(d)(2)(ii) or (iii) or (d)(3) is applicable, is
hereinafter referred to as a “Disqualified Designee”. Each person with the right to designate or participate in the designation of a director as specified above hereby covenants and agrees (A) not to designate or participate in
the designation of any director 

 
designee who, to such person’s knowledge, is a Disqualified Designee and (B) that in the event such person becomes aware that any individual previously designated by any such person is
or has become a Disqualified Designee, such person shall as promptly as practicable take such actions as are necessary to remove such Disqualified Designee from the Board and designate a replacement designee who is not a Disqualified Designee. 

2. Certain Defined Terms. As used in this Agreement, the following terms shall have the following respective meanings: 

2.1. “Additional Stockholders” shall mean the stockholders of the Company who are added as parties to this Agreement pursuant
to Section 15.10(a) hereof and thereafter listed on Schedule D hereto. 
 2.2. “Shares” shall mean and include
any and all shares of Common Stock, Preferred Stock and/or other shares of capital stock of the Company, by whatever name called, which carry voting rights and shall include any such shares now owned or subsequently acquired by a Stockholder,
however acquired, including without limitation by way of stock splits, stock dividends, and the exercise of options. 
 2.3.
“Stockholders” shall mean the Investors, Common Holders, Additional Stockholders and Founders. 
 3. Termination.
This Agreement shall terminate in its entirety on the earliest to occur of (i) the closing of the Company’s initial public offering pursuant to an effective registration statement, if such offering has been approved by the Company’s
Board of Directors, including all of the Preferred Directors, (ii) the closing of the Company’s sale of all or substantially all of its assets or the acquisition of the Company by another entity by means of merger, consolidation or stock
purchase (other than a transaction effected principally to change the domicile of the Company) pursuant to which stockholders of the Company (determined prior to such consolidation or merger) hold less than 50% of the voting equity of the surviving
corporation and (iii) the effective date of the conversion of all of the Preferred Stock. 
 4. No Revocation. The voting
agreements contained herein are coupled with an interest and may not be revoked, except by an amendment, modification or termination effected in accordance with Section 3 or 14.5 hereof. Nothing in this Section 4 shall be construed as
limiting the provisions of Section 3 or 14.5 hereof. 
 5. Restrictive Legend. All certificates representing Shares owned or
hereafter acquired by the Stockholders or any transferee of the Stockholders bound by this Agreement shall have affixed thereto a legend substantially in the following form: 

The securities represented by this certificate are subject to a Voting Agreement, as amended from time to time, by and among the registered
owner of this certificate, the Company and certain other stockholders of the Company. The Company will furnish a copy of this agreement to the holder hereof without charge upon written request. 

 6. Transfers of Obligations and Rights. 

6.1. Any transferee to whom Shares are transferred by a Stockholder, whether voluntarily or by operation of law, shall be bound by the voting
obligations imposed upon, and inure to the benefits of, the transferor under this Agreement, to the same extent as if such transferee were a Stockholder hereunder and no Stockholder shall transfer any Shares unless the transferee agrees in writing
to be bound by this Agreement. 
 6.2. Notwithstanding anything to the contrary herein, any Investor which is a partnership, limited
liability company, corporation, or foundation may transfer rights granted to such Investor hereunder to any partner or member thereof, or to any entity that controls, or is controlled by, or is under common control with, such Investor (an
“Affiliated Entity”) to whom Shares are transferred and who delivers to the Company a written instrument in accordance with Section 6.1. In the event of such transfer, such Affiliated Entity shall be deemed an Investor for
purposes of this Section 6 and may again transfer such rights to any other person or entity which acquires Shares from such partner or member in accordance with, and subject to, the provisions of this Section 6. 

7. Reimbursement of Expenses. The Company shall pay the reasonable out-of-pocket expenses of all directors (other than directors who
are employees of the Company, who shall be reimbursed in accordance with the Company’s employee travel policies) in attending meetings of the Board of Directors and committees thereof (including travel, room and board). 

8. No Liability for Election of Recommended Directors. Neither the Company nor the Investors, nor any officer, director, stockholder,
partner, employee or agent of such party, if any, makes any representation or warranty as to the fitness or competence of the nominee of any party hereunder to serve on the Company’s Board of Directors by virtue of such party’s execution
of this Agreement or by the act of such party in voting for such nominee pursuant to this Agreement. 
 9. Grant of Proxy. Upon the
failure of any Founder, Common Holder, Additional Stockholder or Investor to vote its Shares in accordance with the terms of this Agreement, such Founder, Common Holder, Additional Stockholder or Investor, as appropriate, hereby grants to a
stockholder designated by the Board of Directors of the Company a proxy coupled with an interest in all Shares owned by such stockholder, which proxy shall be irrevocable until this Agreement terminates pursuant to its terms or until this
Section 9 is amended to remove such grant of proxy in accordance with Section 15.5 hereof, to vote all such Shares in the manner provided in Section 1.1 hereof. 

10. No Liability of Stockholders. No Investor shall, by reason of his or its ability to designate and cause the election of any member
of the Board of Directors hereunder, or otherwise, be subject to any liability or obligation whatsoever with respect to the management and affairs of the Company or otherwise be or become responsible for any debts, liabilities or obligations of the
Company. Neither any Stockholder nor any controlling person, officer, director, partner, agent or employee of any Stockholder (each a “Stockholder Agent”) shall be liable to any other Stockholder or Stockholder Agents in
connection with the rights and obligations of such Stockholder arising under this Agreement. 

 11. Bring Along Agreement. 

11.1. For purposes of this Section 11, the terms listed below shall have the following meanings: 

“Affiliate” shall have the meaning ascribed to such term in the Securities Act. 

“Bring-Along Event” shall mean an event approved by (i) Investors holding more than sixty percent (60%) of the
voting power of the Shares then held by all of the Investors (such approving holders, the “Bring-Along Holders”) and (ii) the Board of Directors (including all of the Preferred Directors) pursuant to which the liquidation
preference amounts for the Preferred Stock as set forth in Article FOURTH, Section 3.2 of the Restated Certificate are payable under the terms of the Restated Certificate, other than an event in which the acquiring entity is (x) an
Affiliate of a Bring-Along Holder or (y) an entity of which the Bring-Along Holders own more than ten percent (10%) of the equity securities. 

11.2. Notwithstanding anything herein to the contrary, if any member of the Board of Directors approving the Bring-Along Event is not
disinterested, the provisions of this Section 11 shall not apply unless a majority of the disinterested members of the Board of Directors or a majority of the disinterested holders of Preferred Stock approves the Bring-Along Event. 

11.3. In the event of Bring-Along Event, each Stockholder agrees as follows: 

(a) at every meeting of the stockholders of the Company called with respect to any of the following, and at every adjournment or postponement
thereof, and on every action or approval by written consent of the stockholders of the Company with respect to any of the following, each Stockholder other than a Stockholder that is a Bring-Along Holder (each individually, a “Voting
Holder”, and collectively, the “Voting Holders”) shall vote all Shares that such Voting Holder then holds or for which such Voting Holder otherwise then has voting power: (A) in favor of approval of the Bring-Along
Event and any matter that could reasonably be expected to facilitate the Bring-Along Event, and (B) against any proposal for any recapitalization, merger, sale of assets or other business combination (other than the Bring-Along Event) between
the Company and any person or entity other than the party or parties to the Bring-Along Event or any other action or agreement that would result in a breach of any covenant, representation or warranty or any other obligation or agreement of the
Company under the definitive agreement(s) related to the Bring-Along Event or which could result in any of the conditions to the Company’s obligations under such agreement(s) not being fulfilled; 

(b) if the Bring-Along Event is structured as (A) an equity financing, merger, consolidation or sale of assets, each Voting Holder shall
waive any dissenters’ rights, appraisal rights or similar rights in connection with such financing, merger, consolidation or sale of assets, or (B) a sale of stock, each Voting Holder shall agree to sell all of the Shares and rights to
acquire shares of capital stock of the Company held by such Voting Holder on the terms and conditions approved by the Bring-Along Holders; in each case, for the same amount and type (and relative proportions of each amount and type) of per share
consideration received by the Bring-Along Holders for each class or series of capital stock then held by them (subject to the liquidation preferences contained in the Company’s then effective Certificate of

 
Incorporation). Notwithstanding the foregoing, if, in connection with any Bring-Along Event: (A) any Voting Holder is required to make representations or warranties regarding the Company or
any other selling stockholder (other than those regarding such Voting Holder or the Shares held by it); (B) any such Voting Holder shall be liable for the inaccuracy of any representation or warranty made by any other person or entity in
connection with the acquisition, other than the Company; (C) the liability for indemnification, if any, of such Voting Holder for the inaccuracy of any representations or warranties made by the Company is joint and not several, or is not pro
rata in proportion to the amount of consideration paid to such Voting Holder as a percentage of the consideration paid to all stockholders of the Company in connection with such Bring-Along Event; (D) any Voting Holder is or may become liable
under the agreements related to such Bring-Along Event for indemnification obligations in a manner materially and adversely different from those obligations or potential obligations as the Bring Along Holders; or (E) upon the consummation of
such a Bring-Along Event, the Voting Holder would not receive proceeds from such event in an amount at least equal to the amount provided for in the then effective Certificate of Incorporation of the Company, then, in each case, such Voting Holder
shall not be required to take any action pursuant to Section 11 with respect to such Bring-Along Event; and 
 (c) each Voting Holder
shall take all necessary actions in connection with the consummation of the Bring-Along Event as requested by the Company or the Bring-Along Holders and shall, if requested by the Bring-Along Holders, execute and deliver any agreements prepared in
connection with such Bring-Along Event which agreements are executed by the Bring-Along Holders. 
 11.4. Each Voting Holder hereby grants
to the Chairperson of the Board of Directors of the Company an irrevocable proxy, coupled with an interest, to vote all of such Voting Holder’s Shares and to take such other actions to the extent necessary to carry out the provisions of this
Section 11 in the event of any breach or imminent breach of this Section 11 by such Voting Holder, or its affiliates, successors, custodians or assigns. The Company and the Stockholders each agree and acknowledge that: (i) monetary
damages would not adequately compensate an injured party for the breach of this Section 11 by any party; (ii) this Section 11 shall be specifically enforceable; and (iii) any breach or threatened breach of this Section 11
shall be the proper subject of a temporary or permanent injunction or restraining order. Further, each party hereto waives any claim or defense that there is an adequate remedy at law for such breach or threatened breach. 

11.5. In the event of a conflict between the provisions of this Section 11 and the provisions of that certain Letter Agreement (as
amended from time to time, the “Letter Agreement”), dated on or about November 7, 2013, between the Company and the Bill & Melinda Gates Foundation (the “Foundation”), the parties hereto agree that the
terms of the Letter Agreement shall control and the Foundation shall be deemed to have complied with the provisions of this Section 11 by compliance with the terms of the Letter Agreement. 

12. Observer and Information Rights. 

12.1. Robert Paull or another individual designated by Lux Ventures II, L.P. or an Affiliated Entity (“Lux”) (such individual,
the “Lux Observer”) shall be invited to attend all meetings of the Board of Directors in a non-voting observer capacity, and the Lux Observer shall have access to all information granted to any director in the capacity as a director
of the 

 
Company; provided, however, that the Board, in its sole discretion, can exclude the Lux Observer from attendance at such meetings or access to such information if it determines, in good faith,
that it is advisable due to potential conflicts of interest or to preserve the attorney-client privilege or for similar reasons. The Lux Observer agrees to hold in confidence and trust and not use or disclose any confidential information provided to
or learned by such Lux Observer in connection with the rights provided under this Agreement, in each case other than to Lux in connection with Lux’s monitoring its investment in the Company; provided, that Lux shall be subject to the same
restrictions as the Lux Observer with respect to any confidential information provided to or learned by the Lux Observer in connection with the rights provided under this Agreement. 

12.2. Robert More or another individual designated by the Foundation (such individual, the “Foundation Observer”) shall be
invited to attend all meetings of the Board of Directors in a non-voting observer capacity, and the Foundation Observer shall have access to all information granted to any director in the capacity as a director of the Company; provided, however,
that the Board, in its sole discretion, can exclude the Foundation Observer from attendance at such meetings or access to such information if it determines, in good faith, that it is advisable due to potential conflicts of interest or to preserve
the attorney-client privilege or for similar reasons. The Foundation Observer agrees to hold in confidence and trust and not use or disclose any confidential information provided to or learned by such Foundation Observer in connection with the
rights provided under this Agreement, in each case other than to the Foundation (including Foundation employees, trustees, consultants and other staff) in connection with the Foundation’s monitoring its investment in the Company (including
monitoring compliance with the terms, provisions, rights and obligations set out in the Letter Agreement); provided, that the Foundation (including Foundation employees, trustees, consultants and other staff) shall be subject to the same
restrictions as the Foundation Observer with respect to any confidential information provided to or learned by the Foundation Observer in connection with the rights provided under this Agreement. 

12.3. If the individual initially designated by Merck as the Merck Director pursuant to Section 1.1(b)(v) is not an affiliate of Merck,
and only until such time as the Merck Director is not an affiliate of Merck, then Janelle Anderson or another individual designated by Merck (such individual, the “Merck Observer”) shall be invited to attend all meetings of the
Board of Directors in a non-voting observer capacity, and the Merck Observer shall have access to all information granted to any director in the capacity as a director of the Company; provided, however, that the Board, in its sole discretion, can
exclude the Merck Observer from attendance at such meetings or access to such information if it determines, in good faith, that it is advisable due to potential conflicts of interest or to preserve the attorney-client privilege or for similar
reasons. The Merck Observer agrees to hold in confidence and trust and not use or disclose any confidential information provided to or learned by such Merck Observer in connection with the rights provided under this Agreement, in each case other
than to Merck (including Merck’s employees, consultants and other staff) in connection with Merck’s monitoring its investment in the Company; provided, that Merck shall be subject to the same restrictions as the Merck Observer with respect
to any confidential information provided to or learned by the Merck Observer in connection with the rights provided under this Agreement. For the avoidance of doubt, (i) if the individual initially designated by Merck as the Merck Director
pursuant to Section 1.1(b)(v) is an affiliate of Merck, then Merck shall not have the right to designate a Board observer pursuant to this Section 12.3, and (ii) if, following such individual’s appointment

 
to the Board, the Merck Director becomes an affiliate of Merck, or Merck appoints a new Merck Director who is an affiliate of Merck, then Merck shall no longer have the right to designate a Board
observer pursuant to this Section 12.3. 
 13. Legend. 

13.1. Each certificate representing shares of the Company’s capital stock now or hereafter owned by the Stockholders or issued to any
transferee shall bear the following legend: 
 “THE SALE, PLEDGE, HYPOTHECATION OR TRANSFER OF THE SECURITIES REPRESENTED BY THIS
CERTIFICATE IS SUBJECT TO THE TERMS AND CONDITIONS OF A CERTAIN VOTING RIGHTS AGREEMENT BY AND AMONG THE STOCKHOLDER, THE CORPORATION AND CERTAIN HOLDERS OF COMMON AND PREFERRED STOCK OF THE CORPORATION. COPIES OF SUCH AGREEMENT MAY BE OBTAINED UPON
WRITTEN REQUEST TO THE SECRETARY OF THE CORPORATION.” 
 14. “Bad Actor” Matters. 

14.1. Representation. Each person with the right to designate or participate in the designation of a director pursuant to this Agreement
hereby represents that none of the “bad actor” disqualifying events described in Rule 506(d)(1)(i)-(viii) promulgated under the Securities Act (a “Disqualification Event”) is applicable to such Person or any of its
Rule 506(d) Related Parties, except, if applicable, for a Disqualification Event as to which Rule 506(d)(2)(ii) or (iii) or (d)(3) is applicable. For purposes of this Agreement, “Rule 506(d) Related Party” shall mean with
respect to any person any other person that is a beneficial owner of such first person’s securities for purposes of Rule 506(d) of the Securities Act. 

14.2. Covenant. Each person with the right to designate or participate in the designation of a director pursuant to this Agreement
hereby agrees that it shall notify the Company promptly in writing in the event a Disqualification Event becomes applicable to such person or any of its Rule 506(d) Related Parties, except, if applicable, for a Disqualification Event as to which
Rule 506(d)(2)(ii) or (iii) or (d)(3) is applicable. 
 15. General. 

15.1. Severability. If one or more provisions of this Agreement are held to be invalid, illegal or unenforceable under applicable law,
it shall, as to such jurisdiction, be deemed modified to conform to the minimum requirements of such law or regulation, or, if for any reason it is not deemed so modified, it shall be invalid, illegal or unenforceable only to the extent of such
invalidity, illegality or limitation on enforceability without affecting the remaining provisions of this Agreement, or the validity, legality or enforceability of such provision in any other jurisdiction 

15.2. Specific Performance. In addition to any and all other remedies that may be available at law in the event of any breach of this
Agreement, each Stockholder shall be entitled to specific performance of the agreements and obligations of any other Stockholder 

 
hereunder and to such other injunctive or other equitable relief as may be granted by a court of competent jurisdiction. Further, each party hereto waives any claim or defense that there is an
adequate remedy at law for such breach or threatened breach. 
 15.3. Governing Law. This Agreement shall be governed by, and
construed and enforced in accordance with, the laws of the State of Delaware without regard to its principles of conflicts of laws. 
 15.4.
Notices. All notices, requests, consents, and other communications under this Agreement shall be in writing and shall be deemed effectively given: (a) upon personal delivery to the party to be notified, (b) when sent by confirmed
electronic mail or facsimile if sent during normal business hours of the recipient, and if not so confirmed, then on the next business day, (c) five (5) days after having been sent by registered or certified mail, return receipt requested,
postage prepaid, or (d) one (1) business day after the business day of deposit with a nationally recognized overnight courier, specifying next business day delivery, with written verification of receipt. All communications shall be sent to
the respective parties as follows: 
  

	 	(i)	If to the Company: 

 Visterra, Inc. 

One Kendall Square, Suite B3301 

Cambridge, MA 02139 
 Attn:
Brian Pereira 
 Fax: (617) 498-1073 

with a copy to: 
 Lia Der
Marderosian, Esq. 
 WilmerHale LLP 

60 State Street 
 Boston, MA
02109 
 Fax: 617-526-5000 
  

	 	(ii)	If to an Investor, at its address set forth in Schedule A hereto, or at such other address as may have been furnished to the other parties hereto in writing by such Investor; 

 

	 	(iii)	If to a Founder, at the Company or at such other address or addresses as may have been furnished to the other parties hereto in writing by such Founder; 

 

	 	(iv)	If to a Common Holder, at its address set forth in Schedule C hereto, or at such other address as may have been furnished to the other parties hereto in writing by such Common Holder; and 

 

	 	(v)	 If to an Additional Stockholder, at his or her address set forth in Schedule D hereto, or at such other address as may have been

	 	
furnished to the other parties hereto in writing by such Additional Stockholder. 

Any party may change the address to which notices, requests, consents or other communications hereunder are to be delivered by giving the
other parties notice in the manner set forth in this Section. 
 15.5. Complete Agreement; Amendments. This Agreement constitutes the
entire agreement and understanding of the parties hereto with respect to the subject matter hereof, and supersedes all prior agreements and understandings relating to such subject matter. The Third Amended Agreement is hereby amended and restated in
its entirety and shall be of no further force or effect. No amendment, modification or termination of, or waiver under, any provision of this Agreement shall be valid unless in writing and signed by (i) the Company, (ii) Founders, Common
Holders and Additional Stockholders (taken together) holding at least seventy percent (70%) of the voting power of the shares of Common Stock then held by all of the Founders, Common Holders and Additional Stockholders and (iii) Investors
holding more than sixty percent (60%) of the voting power of the Shares then held by all of the Investors, and any such amendment, modification, termination or waiver shall be binding on all parties hereto, regardless of whether such party has
consented thereto. Notwithstanding the foregoing, (a) the provisions of Section 1.1(b)(i) may be amended and the observance of such Section 1.1(b)(i) may be waived (either generally or in a particular instance and either retroactively
or prospectively) only with the written consent of the Company and Polaris Venture Partners V, L.P.; (b) the provisions of Section 1.1(b)(ii) may be amended and the observance of such Section 1.1(b)(ii) may be waived (either generally
or in a particular instance and either retroactively or prospectively) only with the written consent of the Company and Flagship; (c) the provisions of Section 1.1(b)(v) may be amended and the observance of such Section 1.1(b)(v) may
be waived (either generally or in a particular instance and either retroactively or prospectively) only with the written consent of the Company and Merck; (d) the provisions of Section 12.1 may be amended and the observance of
Section 12.1 may be waived (either generally or in a particular instance and either retroactively or prospectively) only with the written consent of the Company and Lux; (e) the provisions of Section 12.2 may be amended and the
observance of Section 12.2 may be waived (either generally or in a particular instance and either retroactively or prospectively) only with the written consent of the Company and the Foundation; and (f) the provisions of Section 12.3
may be amended and the observance of Section 12.3 may be waived (either generally or in a particular instance and either retroactively or prospectively) only with the written consent of the Company and Merck. 

15.6. Aggregation. All Shares held or acquired by an Investor shall be aggregated with Shares held or acquired by any Affiliated Entity
thereof for purposes of determining the availability of any rights under this Agreement, and the exercise of any such rights may be allocated among such Affiliated Entities in such manner as those Affiliated Entities shall determine. 

15.7. Successors and Assigns. Except as otherwise provided herein, the terms and conditions of this Agreement shall inure to the
benefit of and be binding upon the respective successors and assigns of the Company, the Founders, the Common Holders and the Investors (including transferees of any shares of Preferred Stock or any Common Stock issued upon conversion thereof).
Nothing in this Agreement, express or implied, is intended to confer upon 

 
any party other than the parties hereto or their respective successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly
provided in this Agreement. 
 15.8. Construction. A reference to a Section or Schedule shall mean a Section in or Schedule to this
Agreement unless otherwise expressly stated. The titles and headings herein are for reference purposes only and shall not in any manner limit the construction of this Agreement which shall be considered as a whole. The words “include,”
“includes” and “including” when used herein shall be deemed in each case to be followed by the words “without limitation.” Whenever the context may require, any pronouns used herein shall include the corresponding
masculine, feminine or neuter forms, and the singular form of names and pronouns shall include the plural and vice-versa. 
 15.9.
Counterparts; Facsimile Signatures. This Agreement may be executed in any number of counterparts, each of which shall be deemed to be an original, and all of which. together shall constitute one and the same document. This Agreement may be
executed by facsimile signatures or as a pdf or similar attachment to an electronic transmission. 
 15.10. Additional Parties. 

(a) In the event that after the date of this Agreement, the Company issues shares of Common Stock, or options to purchase Common Stock, to any
employee, and the Company desires to make such employee a party to this Agreement as an Additional Stockholder, such employee shall become a party hereto as an Additional Stockholder (without the need for an amendment to this Agreement or the
consent of any other party hereto) if the Company and such employee execute a counterpart signature page to this agreement (which counterpart signature page shall be kept in the Company’s records). The Company shall add the names of such
Additional Stockholders to Schedule D. 
 (b) The Company will permit each additional purchaser of Series B Preferred Stock pursuant
to the Series B Preferred Stock Purchase Agreement to become party to this Agreement as an Investor by signing a counterpart signature page to this Agreement (which counterpart signature page shall be kept in the Company’s records). The Company
shall add the names of such additional Investors to Schedule A. 
 [Remainder of page intentionally left blank.] 

 IN WITNESS WHEREOF, the parties hereto have executed this Fourth Amended and Restated Voting
Agreement as of the date first written above. 
  

							
	The Company:	 		 	VISTERRA, INC.
				
		 		 	By:	  	  

		 		 	Name:	  	
		 		 	Title:	  	

 Investors: 
  

			
	MERCK SHARP & DOHME CORP.
		
	By:	 	  

	Name:	 	
	Title:	 	

  

													
	POLARIS VENTURE PARTNERS FOUNDERS’ FUND V, L.P.	 		 	POLARIS VENTURE PARTNERS V, L.P.
					
	By:	 	 POLARIS VENTURE MANAGEMENT CO. V, L.L.C.

its General Partner
	 		 	By:	 	 POLARIS VENTURE MANAGEMENT CO. V, L.L.C.

its General Partner

							
		 	By:	 	  
	 		 		 	By:	 	  

		 	Name:	 	William Bilodeau	 		 		 	Name:	 	William Bilodeau
		 	Title:	 	Attorney-in-Fact	 		 		 	Title:	 	Attorney-in-Fact
			
	POLARIS VENTURE PARTNERS SPECIAL FOUNDERS’ FUND V, L.P.	 		 	POLARIS VENTURE PARTNERS ENTREPRENEURS’ FUND V, L.P.
					
	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C. its General Partner	 		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C. its General Partner
							
		 	By:	 	  
	 		 		 	By:	 	  

		 	Name:	 	William Bilodeau	 		 		 	Name:	 	William Bilodeau
		 	Title:	 	Attorney-in-Fact	 		 		 	Title:	 	Attorney-in-Fact

  
 [Signature Page to
Fourth Amended and Restated Voting Agreement] 

									
	Investors (continued):	 		 		 	
			
	FLAGSHIP VENTURES FUND 2007, L.P.	 		 	FLAGSHIP VENTURES FUND IV, L.P.
					
	By:	 	FLAGSHIP VENTURES GENERAL PARTNER L.L.C.	 		 	By:	 	FLAGSHIP VENTURES GENERAL PARTNER L.L.C.
	Its:	 	General Partner	 		 	Its:	 	General Partner
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	Edwin Kania	 		 	Name:	 	Edwin Kania
	Title:	 	Manager	 		 	Title:	 	Manager
				
	FLAGSHIP VENTURES FUND IV-Rx, L.P.	 		 		 	
					
	By:	 	FLAGSHIP VENTURES GENERAL PARTNER L.L.C.	 		 		 	
	Its:	 	General Partner	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 	Edwin Kania	 		 		 	
	Title:	 	Manager	 		 		 	

  
 [Signature Page to
Fourth Amended and Restated Voting Agreement] 

			
	Investors (continued):
	
	 ALEXANDRIA EQUITIES, LLC,
 a
Delaware limited liability company

		
		 	 By: ALEXANDRIA REAL ESTATE EQUITIES, INC.,
 a
Maryland corporation, managing member

		
	By:	 	  

	Name:	 	
	Title:	 	
	
	 OMEGA CAMBRIDGE SPV, L.P.
 By: Omega
Cambridge SPV GP, LLC its General Partner

		
	By:	 	  

	Name:	 	
	Title:	 	Manager
	
	BILL & MELINDA GATES FOUNDATION
		
	By:	 	  

	Name:	 	
	Title:	 	
	
	  

	David Arkowitz
	
	BRIAN J G PEREIRA IRREVOCABLE TRUST
		
	By:	 	  

	Name:	 	
	Title:	 	Trustee
	
	  

	James Delaney
	
	  

	Alan L. Crane

  
 [Signature Page to
Fourth Amended and Restated Voting Agreement] 

									
	Investors (continued):	 		 		 	
				
	  
 Brian J G
Pereira
	 		 		 	

  
 [Signature Page to
Fourth Amended and Restated Voting Agreement] 

									
	Common Holders:	 		 	
			
	 LUX VENTURES II, L.P.
  

By: Lux Venture Partners II, L.P. 
 its General
Partner
 By: Lux Venture Associates II, LLC 
 its
General Partner
 By: Lux Capital Management, LLC

its Sole Member 
	 		 	 LUX VENTURES II SIDECAR, L.P.
  

By: Lux Venture Partners II, L.P. 
 its General
Partner
 By: Lux Venture Associates II, LLC 
 its
General Partner
 By: Lux Capital Management, LLC

its Sole Member

					
	By:	 	  
	 		 	By:	 	  

	Name:	 	Robert Paull	 		 	Name:	 	Robert Paull
	Title:	 	Managing Director	 		 	Title:	 	Managing Director

  
 [Signature Page to
Fourth Amended and Restated Voting Agreement] 

									
	Founders:	 		 	  
 Alan L.
Crane

				
		 		 		 	  
 Ram
Sasisekharan

				
		 		 		 	The Crane Family Irrevocable Trust – 2002
					
		 		 		 	By:	 	  

		 		 		 	Name:	 	Howard R. Crane
		 		 		 	Title:	 	Trustee
				
		 		 		 	Sasisekharan Family 2006 Irrevocable Trust
					
		 		 		 	By:	 	  

		 		 		 	Name:	 	Kenneth S. Federman
		 		 		 	Title:	 	Trustee
				
		 		 		 	Sasisekharan Parents 2006 Irrevocable Trust
					
		 		 		 	By:	 	  

		 		 		 	Name:	 	Kenneth S. Federman
		 		 		 	Title:	 	Trustee
				
		 		 		 	Narayanasami Parents 2006 Irrevocable Trust
					
		 		 		 	By:	 	  

		 		 		 	Name:	 	Kenneth S. Federman
		 		 		 	Title:	 	Trustee
				
		 		 		 	  
 Mahesh
Narayanasami

				
		 		 		 	  
 S. Raguram

  
 [Signature Page to
Fourth Amended and Restated Voting Agreement] 

 Schedule A 

Investors 
 Alexandria Equities, LLC 

385 E. Colorado Boulevard, Suite 299 
 Pasadena, CA 91101 

Attention: Joel S. Marcus, Chief Executive Officer 
 Fax:
626-578-0770 
 David Arkowitz 
 627 Chestnut Street 

Waban, MA 02468 
 Bill & Melinda Gates Foundation 

P.O. Box 23350 
 Seattle, WA 98102 

Attn: Chief Financial Officer 
 Fax: 206-494-7043 

Brian J G Pereira 
 75 Arlington Street 

Winchester, MA 01890 
 Brian J G Pereira Irrevocable Trust 

75 Arlington Street 
 Winchester, MA 01890 

Alan L. Crane 
 c/o Polaris Venture Partners V, L.P. 

Bay Colony Corporate Center 
 1000 Winter Street, Suite 3350 

Waltham, MA 02457 
 James Delaney 

100 Memorial Drive, Apt. 5-2C 
 Cambridge, MA 02142 

Flagship Ventures Fund 2007, L.P. 
 One Memorial Drive 

7th Floor 

Cambridge, MA 02457 
 Flagship Ventures Fund IV, L.P. 

One Memorial Drive 

7th Floor 

Cambridge, MA 02457 

  
 A-1 

 Flagship Ventures Fund IV-Rx, L.P. 

One Memorial Drive 

7th Floor 

Cambridge, MA 02457 
 Merck Sharp & Dohme Corp. 

One Merck Drive 
 P.O. Box 100 

Whitehouse Station, NJ 08889 
 Attn: Office of the Secretary 

Fax: (908) 735-1214 
 Omega Cambridge SPV, L.P. 

c/o Omega Fund Management (US) Inc. 
 545 Boylston Street, Suite
802 
 Boston, MA 02116 
 Polaris Venture Partners V, L.P. 

Bay Colony Corporate Center 
 1000 Winter Street, Suite 3350 

Waltham, MA 02457 
 Attention: William E. Bilodeau 

Fax: 781.290.0880 
 Polaris Venture Partners Entrepreneurs’
Fund V, L.P. 
 Bay Colony Corporate Center 
 1000 Winter
Street, Suite 3350 
 Waltham, MA 02457 
 Attention: William E.
Bilodeau 
 Fax: 781.290.0880 
 Polaris Venture Partners
Founders’ Fund V, L.P. 
 Bay Colony Corporate Center 

1000 Winter Street, Suite 3350 
 Waltham, MA 02457 

Attention: William E. Bilodeau 
 Fax: 781.290.0880 

Polaris Venture Partners Special Founders’ Fund V, L.P. 

Bay Colony Corporate Center 
 1000 Winter Street, Suite 3350 

Waltham, MA 02457 
 Attention: William E. Bilodeau 

Fax: 781.290.0880 

  
 A-2 

 Schedule B 

Founders 
 Alan L. Crane 

Ram Sasisekharan 
 Crane Family Irrevocable Trust – 2002 

Narayanasami Parents 2006 Irrevocable Trust 
 Mahesh Narayanasami

 Sasisekharan Family 2006 Irrevocable Trust 
 Sasisekharan
Parents 2006 Irrevocable Trust 
 S. Raguram 

  
 B-1 

 Schedule C 

Common Holders 
 Lux Ventures II, L.P.

 c/o Lux Capital Management 
 140 East 45th Street, 30th Floor 
 New York, NY 10017 

Lux Ventures II Sidecar, L.P. 
 c/o Lux Capital Management 

140 East 45th Street, 30th Floor 

New York, NY 10017 

  
 C-1 

 Schedule D 

Additional Stockholders 

None. 

  
 D-1 

 AMENDMENT NO. 1 TO 

FOURTH AMENDED AND RESTATED VOTING AGREEMENT 

This Amendment No. 1 to Fourth Amended and Restated Voting Agreement (“Amendment”), dated as of
                    , 2014, amends that certain Fourth Amended and Restated Voting Agreement, dated as of May 15, 2014, by and among Visterra,
Inc. (the “Company”), and the Investors, Founders and Common Holders named therein (the “Voting Agreement”). Capitalized terms used and not defined herein shall have the meanings set forth in the Voting Agreement.

 WHEREAS, the Company, certain Investors, certain Founders, Certain Common Holders and certain other parties are entering into an Amended
and Restated Series B Convertible Preferred Stock Purchase Agreement, of even date herewith (the “Series B Purchase Agreement”), providing for the sale and issuance by the Company of shares of its Series B Convertible
Preferred Stock, $0.01 par value per share (the “Series B Preferred Stock”) and shares of its Common Stock, and certain other matters; and 

WHEREAS, (i) the Company, (ii) Founders, Common Holders and Additional Stockholders (taken together) holding at least seventy
percent (70%) of the voting power of the shares of Common Stock then held by all of the Founders, Common Holders and Additional Stockholders, and (iii) Investors holding more than sixty percent (60%) of the voting power of the Shares
then held by all of the Investors (collectively, the “Requisite Parties”) desire to modify the terms of the Voting Agreement as set forth herein; 

NOW, THEREFORE, in consideration of the mutual covenants contained herein and other good and valuable consideration, the receipt and
sufficiency of which are hereby acknowledged, the Company and the undersigned, constituting the Requisite Parties, hereby agree as follows: 

1. Section 1.1(a). Section 1.1(a) of the Voting Agreement is hereby amended by replacing “seven (7)” with
“eight (8).” 
 2. Section 1.1(b). Section 1.1(b) of the Voting Agreement is hereby deleted in its entirety and
replaced with the following: 
 “elect eight (8) directors, including (i) one director designated by Polaris
Venture Partners V, L.P. or an Affiliated Entity (as defined in Section 6.2), who shall initially be Kevin Bitterman (the “Polaris Director”); (ii) one director designated by Flagship, who shall initially be Edwin Kania
(the “Flagship Director”); (iii) one director designated by Merck Sharp & Dohme Corp. (“Merck”) (the “Merck Director”); (iv) one director collectively designated by V-Sciences
Investments Pte Ltd and Vertex USA Fund Pte. Ltd. (“Vertex”) (the “Vertex Director” and together with the Polaris Director, the Flagship Director and the Merck Director, the “Preferred Directors”));
(v) one director who shall be the Chief Executive Officer of the Company then in office, who shall initially be Brian Pereira (the “CEO Director”); (vi) two directors designated by the holders of at least 70% of the 

 
Common Stock, who shall initially be Alan L. Crane and Ram Sasisekharan; and (vii) one outside director who is not otherwise an affiliate of the Company, any member of the Company’s
management, or any Investor, who shall be designated by the mutual agreement of the other directors (the “Independent Director”).” 

3. Section 1.4. Section 1.4 of the Voting Agreement is hereby deleted in its entirety and replaced with the following: 

“1.4 Approval by the Preferred Directors. For purposes of the Restated Certificate, the Series B Purchase
Agreement, this Agreement, the By-laws, or any other agreement or instrument to which the Company is now or in the future becomes a party, references to any vote, consent, or approval required by or of the Preferred Directors shall mean (i) all
of the Preferred Directors at such times as there are four (4) or fewer Preferred Directors sitting on the Company’s Board of Directors, (ii) four (4) of the Preferred Directors at such times as there are five (5) Preferred
Directors sitting on the Company’s Board of Directors, and (iii) a majority of the Preferred Directors at such times as there are six (6) or more Preferred Directors (the “Requisite Preferred Directors”).” 

4. Section 3. Section 3 of the Voting Agreement is hereby deleted in its entirety and replaced with the following: 

“3. Termination. This Agreement shall terminate in its entirety on the earliest to occur of (i) the closing of
a Qualified IPO (as defined in the Restated Certificate); (ii) the closing of the Company’s sale of all or substantially all of its assets or the acquisition of the Company by another entity by means of merger, consolidation or stock
purchase (other than a transaction effected principally to change the domicile of the Company) pursuant to which stockholders of the Company (determined prior to such consolidation or merger) hold less than 50% of the voting equity of the surviving
corporation; or (iii) the effective date of the conversion of all of the Preferred Stock.” 
 5. Section 11.1.
Clause (i) of the definition of “Bring Along Event” in Section 11.1 of the Voting Agreement is hereby deleted in its entirety and replaced with the following: 

“(i) Investors holding more than seventy percent (70%) of the voting power of the Shares then held by all of the
Investors, with each share of Seed Preferred Stock and Series A Preferred Stock having one vote per share and each share of Series B Preferred Stock having 1.25 votes per share for purposes of such vote (such approving holders, the
“Bring-Along Holders”) and” 
 6. Section 12.3. Section 12.3 of the Voting Agreement is hereby
deleted in its entirety and replaced with the following: 
 “If Merck has not designated its initial director pursuant
to Section 1.1(b)(iii) or if the individual so designated is not an affiliate of Merck, then only until the earlier of such time as (i) any such designated Merck Director is not an affiliate of Merck, or (ii) Merck and its Affiliated
Entities no longer hold 25% of the number of shares of Preferred Stock that they 

  
 -2- 

 
hold immediately following the Second Closing (as defined in the Series B Purchase Agreement), Janelle Anderson or another individual designated by Merck (such individual, the “Merck
Observer”) shall be invited to attend all meetings of the Board of Directors in a non-voting observer capacity, and the Merck Observer shall have access to all information granted to any director in the capacity as a director of the
Company; provided, however, that the Board, in its sole discretion, can exclude the Merck Observer from attendance at such meetings or access to such information if it determines, in good faith, that it is advisable due to potential conflicts of
interest or to preserve the attorney-client privilege or for similar reasons. The Merck Observer agrees to hold in confidence and trust and not use or disclose any confidential information provided to or learned by such Merck Observer in connection
with the rights provided under this Agreement, in each case other than to Merck (including Merck’s employees, consultants and other staff) in connection with Merck’s monitoring its investment in the Company; provided, that Merck shall be
subject to the same restrictions as the Merck Observer with respect to any confidential information provided to or learned by the Merck Observer in connection with the rights provided under this Agreement. For the avoidance of doubt, (i) if the
individual initially designated by Merck as the Merck Director pursuant to Section 1.1(b)(iii) is an affiliate of Merck, then Merck shall not have the right to designate a Board observer pursuant to this Section 12.3, and (ii) if,
following such individual’s appointment to the Board, the Merck Director becomes an affiliate of Merck, or Merck appoints a new Merck Director who is an affiliate of Merck, then Merck shall no longer have the right to designate a Board observer
pursuant to this Section 12.3.” 
 7. Section 12.4. The following is inserted immediately following Section 12.3
of the Voting Agreement and shall be Section 12.4 of the Voting Agreement: 
 “12.4. Until such time as Vertex and
its Affiliated Entities no longer hold 25% of the number of shares of Preferred Stock that they hold immediately following the Second Closing (as defined in the Series B Purchase Agreement), Vertex shall have the right to designate one
individual (the “Vertex Observer”) who shall be invited to attend all meetings of the Board of Directors in a non-voting observer capacity, and the Vertex Observer shall have access to all information granted to any director in the
capacity as a director of the Company; provided, however, that the Board, in its sole discretion, can exclude the Vertex Observer from attendance at such meetings or access to such information if it determines, in good faith, that it is advisable
due to potential conflicts of interest or to preserve the attorney-client privilege or for similar reasons. The Vertex Observer agrees to hold in confidence and trust and not use or disclose any confidential information provided to or learned by
such Vertex Observer in connection with the rights provided under this Agreement, in each case other than to Vertex (including Vertex’s employees, consultants and other staff) in connection with Vertex’s monitoring its investment in the
Company; provided, that Vertex shall be subject to the same restrictions as the Vertex Observer with respect to any confidential information provided to or learned by the Vertex Observer in connection with the rights provided under this
Agreement.” 
 8. Section 15.5(iii). Section 15.5(iii) of the Voting Agreement is hereby deleted in its entirety and
replaced with the following: 

  
 -3- 

 “Investors holding more than seventy percent (70%) of the voting power
of the Shares then held by all of the Investors, with each share of Seed Preferred Stock and Series A Preferred Stock having one vote per share and each share of Series B Preferred Stock having 1.25 votes per share for purposes of such
vote, and any such amendment, modification, termination or waiver shall be binding on all parties hereto, regardless of whether such party has consented thereto.” 

9. Section 15.5(c). Subsection 15.5(c) is deleted in its entirety and replaced with the following: 

“(c) the provisions of Section 1.1(b)(iii) may be amended and the observance of such Section 1.1(b)(iii) may be
waived (either generally or in a particular instance and either retroactively or prospectively) only with the written consent of the Company and Merck;” 

10. Section 15.5. The “and” immediately prior to Subsection 15.5(f) is hereby struck and the following is added to the
end of Section 15.5 of the Voting Agreement: 
 “; and (g) the provisions of Section 12.4 may be amended
and the observance of Section 12.4 may be waived (either generally or in a particular instance and either retroactively or prospectively) only with the written consent of the Company and Vertex.” 

11. Requisite Preferred Directors. The phrase “all of the Preferred Directors” in each of Section 1.3, Section 3(i)
and subsection (ii) of the definition of Bring-Along Event in Section 11.1 of the Voting Agreement is hereby deleted and replaced in each instance with the phrase “the Requisite Preferred Directors”. 

12. Entire Agreement. The Voting Agreement, as amended by this Amendment, together with the other writings referred to in the Voting
Agreement or delivered pursuant thereto which form a part thereof, contain the entire agreement among the parties with respect to the subject matter thereof and amend, restate and supersede all prior and contemporaneous arrangements or
understandings with respect thereto. 
 13. Effectiveness. Upon the effectiveness of this Amendment, on and after the date hereof,
each reference in the Voting Agreement to “this Agreement,” “hereunder,” “hereof,” “herein” or words of like import, and each reference in the other documents entered into in connection with the Voting
Agreement, shall mean and be a reference to the Voting Agreement, as amended hereby. Except as specifically amended above, the Voting Agreement shall remain in full force and effect and is hereby ratified and confirmed. 

14. Governing Law. This Amendment shall be governed by, and construed and enforced in accordance with, the laws of the state of
Delaware without regard to its principles of conflicts of laws. 
 15. Counterpart Signature Pages. This Amendment may be executed in
two or more counterparts, each of which shall be deemed to be an original, but all of which shall be one and the same document. 

  
 -4- 

 [Remainder of page intentionally left blank.] 

  
 -5- 

 IN WITNESS WHEREOF, this Amendment has been executed by the parties hereto as of the day and year
first above written. 
  

									
	The Company:	 		 	VISTERRA, INC.
					
		 		 		 	By:	 	  

		 		 		 	Name:	 	Brian Pereira
		 		 		 	Title:	 	President and Chief Executive Officer
				
	Investors:	 		 		 	
				
	MERCK SHARP & DOHME CORP.	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 		 		 		 	
			
	POLARIS VENTURE PARTNERS FOUNDERS’ FUND V, L.P.	 		 	POLARIS VENTURE PARTNERS V, L.P.
					
	By:	 	 POLARIS VENTURE
 MANAGEMENT CO. V,
L.L.C.
	 		 	By:	 	 POLARIS VENTURE
 MANAGEMENT CO. V,
L.L.C.

		 	its General Partner	 		 		 	its General Partner
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	William Bilodeau	 		 	Name:	 	William Bilodeau
	Title:	 	Attorney-in-Fact	 		 	Title:	 	Attorney-in-Fact
			
	POLARIS VENTURE PARTNERS SPECIAL FOUNDERS’ FUND V, L.P.	 		 	POLARIS VENTURE PARTNERS ENTREPRENEURS’ FUND V, L.P.
					
	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C. its General Partner	 		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C. its General Partner
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	William Bilodeau	 		 	Name:	 	William Bilodeau
	Title:	 	Attorney-in-Fact	 		 	Title:	 	Attorney-in-Fact

  
 [Signature Page to
Amendment No. 1 to Fourth Amended and Restated Voting Agreement] 

									
	Investors (continued):	 		 		 	
			
	FLAGSHIP VENTURES FUND 2007, L.P.	 		 	FLAGSHIP VENTURES FUND IV, L.P.
					
	By:	 	 FLAGSHIP VENTURES 2007 GENERAL PARTNER L.L.C.

Its: General Partner
	 		 	By:	 	 FLAGSHIP VENTURES FUND IV GENERAL PARTNER L.L.C.

Its: General Partner

					
	By:	 	  
	 		 	By:	 	  

	Name:	 	Edwin Kania	 		 	Name:	 	Edwin Kania
	Title:	 	Manager	 		 	Title:	 	Manager
				
	FLAGSHIP VENTURES FUND IV-Rx, L.P.	 		 		 	
					
	By:	 	 FLAGSHIP VENTURES FUND IV GENERAL PARTNER L.L.C.

Its: General Partner
	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 	Edwin Kania	 		 		 	
	Title:	 	Manager	 		 		 	
				
	 ALEXANDRIA EQUITIES, LLC,
 a
Delaware limited liability company
	 		 		 	
					
	By:	 	 ALEXANDRIA REAL ESTATE EQUITIES, INC.,
 a
Maryland corporation, managing member
	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 		 		 		 	
				
	OMEGA CAMBRIDGE SPV, L.P.	 		 		 	
					
	By:	 	Omega Cambridge SPV GP, LLC	 		 		 	
		 	its General Partner	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 	Manager	 		 		 	

  
 [Signature Page to
Amendment No. 1 to Fourth Amended and Restated Voting Agreement] 

									
	Investors (continued):	 		 		 	
				
	BILL & MELINDA GATES FOUNDATION	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 		 		 		 	
				
	  
	 		 		 	
	David Arkowitz	 		 		 	
				
	  
	 		 		 	
	James Delaney	 		 		 	
				
	  
	 		 		 	
	Alan L. Crane	 		 		 	
				
	  
	 		 		 	
	Brian J G Pereira	 		 		 	
				
	BRIAN J G PEREIRA IRREVOCABLE TRUST	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 	Trustee	 		 		 	

  
 [Signature Page to
Amendment No. 1 to Fourth Amended and Restated Voting Agreement] 

									
	Common Holders:	 		 		 	
			
	LUX VENTURES II, L.P.	 		 	LUX VENTURES II SIDECAR, L.P.
					
	By:	 	Lux Venture Partners II, L.P.	 		 	By:	 	Lux Venture Partners II, L.P.
	Its:	 	General Partner	 		 	Its:	 	General Partner
	By:	 	Lux Venture Associates II, LLC	 		 	By:	 	Lux Venture Associates II, LLC
	Its:	 	General Partner	 		 	Its:	 	General Partner
	By:	 	Lux Capital Management, LLC	 		 	By:	 	Lux Capital Management, LLC
	Its:	 	Sole Member	 		 	Its:	 	Sole Member
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	Peter Hebert	 		 	Name:	 	Peter Hebert
	Title:	 	Managing Director	 		 	Title:	 	Managing Director
				
	Founders:	 		 		 	
				
		 		 		 	  

		 		 		 	Alan L. Crane
				
		 		 		 	  

		 		 		 	Ram Sasisekharan
				
		 		 		 	The Crane Family Irrevocable Trust – 2002
					
		 		 		 	By:	 	  

		 		 		 	Name:	 	Howard R. Crane
		 		 		 	Title:	 	Trustee

  
 [Signature Page to
Amendment No. 1 to Fourth Amended and Restated Voting Agreement] 

									
	Sasisekharan Family 2006 Irrevocable Trust	 		 	Sasisekharan Family 2006 Irrevocable Trust
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	S. Raguram	 		 	Name:	 	Kenneth S. Federman
	Title:	 	Trustee	 		 	Title:	 	Trustee
			
	Sasisekharan Parents 2006 Irrevocable Trust	 		 	Sasisekharan Parents 2006 Irrevocable Trust
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	V. Sasisekharan	 		 	Name:	 	Kenneth S. Federman
	Title:	 	Trustee	 		 	Title:	 	Trustee
			
	Narayanasami Parents 2006 Irrevocable Trust	 		 	Narayanasami Parents 2006 Irrevocable Trust
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	S. Raguram	 		 	Name:	 	Kenneth S. Federman
	Title:	 	Trustee	 		 	Title:	 	Trustee
				
		 		 		 	  

		 		 		 	Mahesh Narayanasami
				
		 		 		 	  

		 		 		 	S. Raguram

  
 [Signature Page to
Amendment No. 1 to Fourth Amended and Restated Voting Agreement] 

 EXHIBIT C 

Form of Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement, 

as amended by Amendment No. 1 thereto 

 FOURTH AMENDED AND RESTATED 

RIGHT OF FIRST REFUSAL AND CO-SALE AGREEMENT 

This Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement dated as of May 15, 2014 (this
“Agreement”), is made by and among Visterra, Inc., a Delaware corporation (the “Company”), each holder of the Company’s Seed Convertible Preferred Stock, $0.01 par value per share (“Seed Preferred
Stock”), Series A Convertible Preferred Stock, $0.01 par value per share (“Series A Preferred Stock”), and Series B Convertible Preferred Stock, $0.01 par value per share (“Series B Preferred Stock” and,
together with the Seed Preferred Stock and the Series A Preferred Stock, the “Preferred Stock”) listed on Schedule A hereto (each individually, an “Investor” and collectively, the
“Investors”); and the holders of shares of Common Stock, $0.0001 par value per share (the “Common Stock”) of the Company listed on Schedule B hereto (each individually, a “Founder” and
collectively, the “Founders”). 
 WHEREAS, the Founders own shares of Common Stock. 

WHEREAS, the Company, certain of the Investors and the Founders are parties to a Third Amended and Restated Right of First Refusal and Co-Sale
Agreement dated May 12, 2012, as amended by Amendment No. 1 thereto dated September 12, 2012 (as amended, the “Third Amended Agreement”). 

WHEREAS, concurrently with the execution of this Agreement, the Company and certain of the Investors are entering into a Series B Convertible
Preferred Stock Purchase Agreement (the “Series B Purchase Agreement”) providing for the sale of shares of Series B Preferred Stock. Capitalized terms not otherwise defined herein shall have the meanings given to them in the Series
B Purchase Agreement. 
 WHEREAS, in connection with the transactions contemplated by the Series B Purchase Agreement and to induce certain
of the Investors to purchase shares of Series B Preferred Stock pursuant to the Series B Purchase Agreement, the Company, the Investors and the Founders have agreed to amend and restate the Third Amended Agreement as set forth herein. 

NOW, THEREFORE, in consideration of the premises and the mutual covenants set forth herein, the parties hereto hereby agree as follows: 

1. Certain Defined Terms. As used in this Agreement, the following terms shall have the following respective meanings: 

1.1 “Additional Stockholders” shall mean the stockholders of the Company who are added as parties to this Agreement pursuant
to Section 10.9(a) hereof and thereafter listed on Schedule C hereto. 
 1.2 “Immediate Family” shall mean any
spouse, child, stepchild, grandchild, parent, stepparent, grandparent, uncle, aunt, niece, nephew, sibling, mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law or sister-in-law and shall include adoptive relationships. 

 1.3 “Shares” shall mean and include all Stock now owned or hereafter acquired by
any Stockholder. 
 1.4 “Stock” shall mean and include: all shares of Common Stock and any evidences of indebtedness,
shares of capital stock or other securities directly or indirectly convertible into or exchangeable for Common Stock (“Convertible Securities”), including the Preferred Stock; any rights, options or warrants to subscribe for,
purchase or otherwise acquire Common Stock or Convertible Securities (“Options”); and all other securities of the Company which may be issued in exchange for or in respect of shares of Common Stock, Convertible Securities or Options
(whether by way of stock split, stock dividend, combination of shares, reclassification, recapitalization, reorganization, or any other means). 

1.5 “Stockholders” shall mean the Investors, Additional Stockholders and Founders. 

In addition, for purposes of all calculations and notices under this Agreement, and all other provisions of this Agreement where the context
permits, the Stock owned by a Founder or Additional Stockholder shall be deemed to include any Stock held by such Founder or Additional Stockholder which is subject to one or more other agreements between the Company, on the one hand, and such
Founder or Additional Stockholder, on the other hand, granting the Company the right to repurchase such Stock or otherwise restricting such Founder’s or Additional Stockholder’s right to transfer such Stock (the “Other Stock
Restriction Agreements”). Notwithstanding the foregoing, nothing in this Agreement shall be deemed to authorize a Founder or Additional Stockholder to transfer any Shares in violation of the terms of any Other Stock Restriction Agreement
and the Company reserves all of its rights under such agreements. 
 2. Restrictions on Transfer. 

2.1 Any sale, assignment, transfer, gift or other disposition, whether voluntarily or by operation of law (collectively,
“Transfer”), of any of the Shares by a Founder or Additional Stockholder, other than according to the terms of this Agreement, shall be null and void and shall transfer no right, title, or interest in or to any of such Shares to the
purported transferee. 
 2.2 An original copy of this Agreement, duly executed by each of the parties hereto, shall be delivered to the
Secretary of the Company and maintained at the principal executive office of the Company and made available for inspection by any person requesting it. 

2.3 Each Founder and Additional Stockholder agrees to present the certificates representing the Shares presently owned or hereafter acquired
by him to the Secretary of the Company and cause the Secretary to stamp on the certificate in a prominent manner the following legend: 
 The
sale or other disposition of any of the securities represented by this certificate is restricted by a Right of First Refusal and Co Sale Agreement, as amended from time to time, by and among the registered owner of this certificate, the Company and
certain other stockholders of the Company. 

  
 - 2 - 

 
The Company will furnish a copy of this agreement to the holder hereof without charge upon written request. 

2.4 Each Founder and Additional Stockholder agrees that the Company may instruct its transfer agent to impose transfer restrictions on the
shares represented by certificates bearing the legend referred to in Section 2.3 above to enforce the provisions of this Agreement and the Company agrees to promptly do so. The legend shall be removed upon termination of this Agreement. 

3. Transfers Not Subject to Restrictions. 

3.1 Subject to the provisions of Section 3.2, the Company’s and the Investors’ rights of first refusal and the Investors’
right of co-sale described in Sections 5 through 7 shall not apply to: (1) in the case of a Founder or an Additional Stockholder who is a natural person, (i) any Transfer of Shares by such Founder or Additional Stockholder by gift or
bequest or through inheritance to, or for the benefit of, any member or members of such Founder’s or Additional Stockholder’s or such Founder’s or Additional Stockholder’s spouse’s Immediate Family or (ii) any Transfer
of Shares by such Founder or Additional Stockholder to a trust (A) in respect of which such Founder or Additional Stockholder serves as trustee, provided that the trust instrument governing such trust shall provide that such Founder or
Additional Stockholder, as trustee, shall retain sole and exclusive control over the voting and disposition of such Shares until the termination of this Agreement or (B) for the benefit solely of any member or members of such Founder’s or
Additional Stockholder’s or such Founder’s or Additional Stockholder’s spouse’s Immediate Family; (2) in the case of all Founders, any Transfer of Shares to the Company or with respect to Transfers of up to an aggregate of
up to 10% of the Shares held by a Founder as of the date such Founder first became party to this Agreement (or a prior version of this Agreement) and (3) in the case of all Additional Stockholders, any Transfer of Shares to the Company or with
respect to Transfers of up to an aggregate of up to 10% of the Shares held by an Additional Stockholder as of the date such Additional Stockholder first became party to this Agreement. 

3.2 In the event of any Transfer described in clauses (1)(i) or (1)(ii) of Section 3.1, the transferee of the Shares shall hold
the Shares so acquired subject to all the restrictions imposed by this Agreement and shall be deemed a Founder or Additional Stockholder, as applicable, for all purposes hereof, and as a condition precedent to the validity of such Transfer, any such
transferee must execute and deliver to the Company a written instrument agreeing to be bound by the provisions of this Agreement. 
 4.
Offer of Transfer; Notice of Proposed Transfer. If a Founder or Additional Stockholder desires to Transfer any of his or her Shares, or any interest in such Shares, in any transaction other than pursuant to Section 3 of this Agreement,
such Founder or Additional Stockholder (a “Selling Founder” or “Selling Additional Stockholder”) shall first (i) deliver written notice of his or her desire to do so (the “Notice”) to the
Company and each Investor, in the manner prescribed in Section 10.4 of this Agreement. The Notice must specify: (i) the name and address of the party to which the Selling Founder or Selling Additional Stockholder proposes to Transfer the
Shares or an interest in the Shares (the “Offeror”), (ii) the number of Shares the Selling Founder or Selling Additional Stockholder proposes to Transfer (the “Offered Shares”),

  
 - 3 - 

 
(iii) the consideration per Share to be delivered to the Selling Founder or Selling Additional Stockholder for the proposed Transfer, and (iv) all other material terms and conditions of the
proposed transaction. 
 5. Company’s First Refusal Right. 

5.1 Subject to Section 7.1, the Company shall have the option to purchase all or any part of the Offered Shares for the consideration per
Share and on the terms and conditions specified in the Notice (the “First Refusal Right”). This First Refusal Right shall supersede any similar right granted to the Company in any prior agreement to the extent such similar right is
then in effect and to the extent such similar right conflicts with the First Refusal Right. The Company must exercise its First Refusal Right no later than 15 days after such Notice is deemed under Section 10.4 hereof to have been delivered to
it by written notice to the Selling Founder or Selling Additional Stockholder. 
 5.2 In the event the Company does not exercise its First
Refusal Right within such 15 day period (the “First Refusal Period”) with respect to all of the Offered Shares, the Company shall, by the last day of such period, give written notice (the “Investor Notice”) of that
fact to the Investors, Founders and Additional Stockholders. The Investor Notice shall specify the number of Offered Shares not purchased by the Company (the “Remaining Shares”). 

5.3 In the event the Company duly exercises its First Refusal Right to purchase all or part of the Offered Shares, the closing of such
purchase shall take place at the offices of the Company on the later of (i) the date five days after the expiration of the First Refusal Period and (ii) the date that the Investors consummate their purchase of Remaining Shares under
Section 6.3 hereof. 
 5.4 To the extent that the consideration proposed to be paid by the Offeror for the Offered Shares consists of
property other than cash or a promissory note, the consideration required to be paid by the Company and/or Investors exercising their first refusal rights under Section 5 and Section 6 hereof may consist of cash equal to the value of such
property, as determined in good faith by agreement of the Selling Founder or Selling Additional Stockholder, the Company and/or the Investors acquiring such Offered Shares; provided, however, that if the parties to any such sale of Offered Shares
cannot agree on the value of such property, the value shall be determined by an appraiser mutually acceptable to such parties and the cost of the appraisal shall be borne equally by such parties. 

5.5 If the Company (or its assignees) makes a timely exercise of the First Refusal Right with respect to a portion, but not all, of the
Offered Shares specified in the Notice, the Selling Founder or Selling Additional Stockholder shall have the option, exercisable by written notice to the Company delivered within sixty (60) days after the date of the Notice, to effect the sale
of the Offered Shares pursuant to one of the following alternatives: 
 (a) sale or other disposition of all the Offered Shares to the
Investors (if the Investors exercise their Secondary Refusal Right (as defined below)) or the Offeror(s) (if the Investors do not exercise their Secondary Refusal Right) identified in the Notice, but in full

  
 - 4 - 

 
compliance with the requirements of Section 6 and Section 7, as if the Company did not exercise the First Refusal Right hereunder; or 

(b) sale to the Company (or its assignees) of the portion of the Offered Shares that the Company (or its assignees) has elected to purchase,
such sale to be effected in substantial conformity with the provisions of this Agreement. 
 The failure of the Selling Founder or Selling
Additional Stockholder to deliver timely notification to the Company under this Section 5.5 shall be deemed to be an election by the Selling Founder of Selling Additional Stockholder to sell the Offered Shares pursuant to alternative
(a) above. 
 6. Investors’ Secondary Refusal Right. 

6.1 Subject to Section 7.1, each Investor shall have an option, exercisable for a period of 15 days from the date of delivery of the
Investor Notice, to purchase his or its Pro Rata Share (as defined below) of the Remaining Shares for the consideration per Share and on the terms and conditions set forth in the Notice (the “Secondary Refusal Right”). The Secondary
Refusal Right shall be exercised by delivery by such Investor of written notice to the Secretary of the Company. Alternatively, each Investor may, within the same 15 day period, notify the Secretary of the Company of its desire to participate in the
sale of the Shares on the terms set forth in the Notice, and the number of Shares it wishes to sell. For the purposes of this Agreement, the term “Pro Rata Share” shall mean that number of shares of Common Stock equal to the product
obtained by multiplying (i) the aggregate number of Offered Shares covered by the Notice (less any Offered Shares purchased by the Company pursuant to its First Refusal Right) by (ii) a fraction, the numerator of which is the number of
shares of Stock owned by the Investor at the time of the sale or transfer and the denominator of which is the total number of shares of Stock owned by all Investors at the time of the sale or transfer. 

6.2 In the event the Secondary Refusal Right has been exercised by the Investors with respect to some but not all of the Remaining Shares,
those Investors who have exercised their Secondary Refusal Rights within the 15 day period specified in Section 6.1 shall have an additional option (the “Overallotment Option”), for a period of five days next succeeding the
expiration of such 15 day period, to purchase all or any part of the balance of such Remaining Shares on the terms and conditions set forth in the Notice, which Overallotment Option shall be exercised by the delivery of written notice to the
Secretary of the Company. In the event there are two or more such Investors that choose to exercise the Overallotment Option for a total number of Remaining Shares in excess of the number available, each such Investor shall be allocated its
Overallotment Pro Rata Share. The term “Overallotment Pro Rata Share” with respect to such Investor shall mean that number of shares of Stock equal to the product obtained by multiplying (i) the aggregate number of Offered
Shares not already purchased by the Company and the Investors by (ii) a fraction, the numerator of which is the number of shares of Stock owned by such Investor exercising her, her, or its Secondary Refusal Right at the time of the sale or
transfer and the denominator of which is the total number of shares of Stock owned by all Investors exercising their Secondary Refusal Rights at the time of the sale or transfer. Each Investor exercising its Secondary Refusal Rights shall be
entitled to apportion shares to be purchased among its partners and affiliates (including, in the case of a 

  
 - 5 - 

 
venture capital fund, other venture capital funds affiliated with such fund), provided that such Investor notifies the Selling Founder and the Company of such allocation. 

6.3 If the options to purchase the Remaining Shares are exercised in full by the Investors, the Company shall immediately notify all of the
exercising Investors of that fact. The closing of the purchase of the Remaining Shares shall take place at the offices of the Company no later than five days after the date of such notice to the Investors. 

7. Failure to Fully Exercise First and Secondary Refusal Rights; Co Sale Right. 

7.1 If a Selling Founder or Selling Additional Stockholder proposes to sell any shares of Stock (i) as to which the Company either waived
or failed to fully exercise its First Refusal Right with respect to such shares and (ii) that have not been purchased by the Investors pursuant to the Secondary Refusal Right, then such Selling Founder or Selling Additional Stockholder promptly
shall give written notice (the “Sale Notice”) to the Company and the Investors at least twenty (20) days prior to the closing of such proposed sale. The Investors shall have the right, exercisable by written notice to the
Selling Founder or Selling Additional Stockholder within ten (10) days after deemed delivery of the Sale Notice pursuant to Section 10.4 hereof, to participate (as a seller) in such sale of Stock on the same terms and conditions and as set
forth in this Section 7 (each Investor that exercises its right to participate in such sale, a “Participating Investor”). The Company shall promptly, on expiration of the periods during which the Company and the Investors may
exercise their First Refusal Right and Second Refusal Right, respectively, notify the Selling Founder or Selling Additional Stockholder of the aggregate number of Shares the Participating Investors wish to sell (the “Option
Period”). The Selling Founder or Selling Additional Stockholder shall use his or her best efforts to interest the Offeror in purchasing, in addition to the Offered Shares, the Shares the Participating Investors wish to sell. If the Offeror
does not wish to purchase all of the Shares made available by the Selling Founder or Selling Additional Stockholder and the Participating Investors, then each Participating Investor and the Selling Founder or Selling Additional Stockholder shall be
entitled to sell, at the price and on the terms and conditions set forth in the Notice, a portion of the Shares being sold to the Offeror, in the same proportion as such Selling Founder or Selling Additional Stockholder or Participating
Investor’s ownership of Shares bears to the aggregate number of Shares owned by the Selling Founder or Selling Additional Stockholder and the Participating Investors. The transaction contemplated by the Notice shall be consummated not later
than 60 days after the expiration of the Option Period. 
 7.2 If the Participating Investors do not elect to sell the full number of Shares
which they are entitled to sell pursuant to Section 7.1, the Selling Founder or Selling Additional Stockholder shall be entitled to sell to the Offeror, according to the terms set forth in the Notice, that number of his or her own Shares which
equals the difference between the number of Shares desired to be purchased by the Offeror and the number of Shares the Participating Investors are entitled to sell pursuant to Section 7.1. If the Selling Founder or Selling Additional
Stockholder wishes to Transfer any such Shares at a price per Share which differs from that set forth in the Notice, upon terms different from those previously offered to the Company and the Investors, or more than 60 days after the expiration of
the Option Period, then, as a condition precedent to such transaction, such Shares must first be offered to the Company and the Investors on the same 

  
 - 6 - 

 
terms and conditions as given the Offeror, and in accordance with the procedures and time periods set forth above. 

7.3 The proceeds of any sale made by the Selling Founder or Selling Additional Stockholder without compliance with the provisions of this
Section 7 shall be deemed to be held in constructive trust in such amount as would have been due the Participating Investors if the Selling Founder or Selling Additional Stockholder had complied with this Agreement. 

8. Termination of Agreement. This Agreement shall terminate upon the earliest to occur of (i) the closing of the Company’s
initial public offering pursuant to an effective registration statement if such offering has been approved by the Company’s Board of Directors, including all of the Preferred Directors (as defined in the Company’s Certificate of
Incorporation, as amended), (ii) the closing of a merger, consolidation or similar transaction as described in Article Fourth, Section 3.2(e) of the Company’s Certificate of Incorporation, as amended, and (iii) the effective date
of the conversion of all of the Preferred Stock into Common Stock. 
 9. Transfers. 

(a) This Agreement, and the rights and obligations of an Investor hereunder, may be assigned by such Investor to any person or entity which
acquires at least 25% of the shares of Preferred Stock held by such Investor, and such transferee shall be deemed an “Investor” for purposes of this Agreement; provided, that, the Company must be furnished with written notice of such
assignment and the transferee must agree in writing to be bound by the terms and conditions set forth herein. 
 (b) Notwithstanding
anything to the contrary herein, any Investor which is a partnership, limited liability company, corporation, or foundation may transfer rights granted to such Investor hereunder to any partner or member thereof, or any entity that controls, or is
controlled by, or is under common control with, such Investor (an “Affiliated Entity”) to whom Shares are transferred and who delivers to the Company a written instrument in accordance with subparagraph (a) above. In the event
of such transfer, such Affiliated Entity shall be deemed an Investor, for purposes of this Section 9 and may again transfer such rights to any other person or entity which acquires Shares from such partner or member in accordance with, and
subject to, the provisions of this Section 9. 
 10. General. 

10.1 Severability. If one or more provisions of this Agreement are held to be invalid, illegal or unenforceable under applicable law, it
shall, as to such jurisdiction, be deemed modified to conform to the minimum requirements of such law or regulation, or, if for any reason it is not deemed so modified, it shall be invalid, illegal or unenforceable only to the extent of such
invalidity, illegality or limitation on enforceability without affecting the remaining provisions of this Agreement, or the validity, legality or enforceability of such provision in any other jurisdiction. 

  
 - 7 - 

 10.2 Specific Performance. In addition to any and all other remedies that may be available
at law in the event of any breach of this Agreement, the Company, the Investors, the Founders and the Additional Stockholders shall be entitled to specific performance of the agreements and obligations of the parties hereunder and to such other
injunctive or other equitable relief as may be granted by a court of competent jurisdiction. Further, each party hereto waives any claim or defense that there is an adequate remedy at law for such breach or threatened breach. 

10.3 Governing Law. This Agreement shall be governed by, and construed and enforced in accordance with, the laws of the State of
Delaware without regard to its principles of conflicts of laws. 
 10.4 Notices. All notices, requests, consents, and other
communications under this Agreement shall be in writing and shall be deemed effectively given: (a) upon personal delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal business
hours of the recipient, and if not so confirmed, then on the next business day, (c) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one (1) business day
after the business day of deposit with a nationally recognized overnight courier, specifying next business day delivery, with written verification of receipt. All communications shall be sent to the respective parties as follows: 

 

	 	(i)	If to the Company: 

 Visterra, Inc. 

One Kendall Square, Suite B3301 

Cambridge, MA 02139 
 Attn:
Brian Pereira 
 Fax: (617) 498-1073 

with a copy to: 
 Lia Der
Marderosian, Esq. 
 WilmerHale LLP 

60 State Street 
 Boston, MA
02109 
 Fax: (617) 526-5000 
  

	 	(ii)	If to an Investor, at its address set forth in Schedule A hereto, or at such other address as may have been furnished to the other parties hereto in writing by such Investor; 

 

	 	(iii)	If to a Founder, at the Company or at such other address or addresses as may have been furnished to the other parties hereto in writing by such Founder; and 

  
 - 8 - 

	 	(iv)	If to an Additional Stockholder, at his or her address set forth in Schedule C hereto, or at such other address as may have been furnished to the other parties hereto in writing by such Additional Stockholder;
and 

 Any party may change the address to which notices, requests, consents or other communications hereunder are to be
delivered by giving the other parties notice in the manner set forth in this Section. 
 10.5 Complete Agreement; Amendments. This
Agreement constitutes the full and complete agreement of the parties hereto with respect to the subject matter hereof, and supersedes all prior agreements and understandings, written or oral, of the parties hereto relating to such subject matter.
The Third Amended Agreement is hereby amended and restated in its entirety and shall be of no further force or effect. No amendment, modification or termination of any provision of this Agreement shall be valid unless in writing and signed by
(i) the Company, (ii) Founders and Additional Stockholders (taken together) holding at least seventy percent (70%) of the voting power of the Shares then restricted by this Agreement, and (iii) Investors holding more than sixty
percent (60%) of the voting power of the Stock then held by all Investors and any such amendment, modification, termination or waiver shall be binding on all parties hereto, regardless of whether such party has consented thereto. 

10.6 Aggregation. All Shares held or acquired by an Investor which is a partnership or a limited liability company shall be aggregated
with Shares held or acquired by any of Affiliated Entity thereof for purposes of determining the availability of any rights under this Agreement, and the exercise of any such rights may be allocated among such Affiliated Entities in such manner as
those Affiliated Entities shall determine. 
 10.7 Construction. A reference to a Section or Schedule shall mean a Section in or
Schedule to this Agreement unless otherwise expressly stated. The titles and headings herein are for reference purposes only and shall not in any manner limit the construction of this Agreement which shall be considered as a whole. The words
“include,” “includes” and “including” when used herein shall be deemed in each case to be followed by the words “without limitation.” Whenever the context may require, any pronouns used herein shall include
the corresponding masculine, feminine or neuter forms, and the singular form of names and pronouns shall include the plural and vice-versa. 

10.8 Counterparts; Facsimile. This Agreement may be executed in any number of counterparts, each of which shall be deemed to be an
original, and all of which together shall constitute one and the same document. This Agreement may be executed by facsimile signatures. 

10.9 Additional Parties. 

(a) In the event that after the date of this Agreement, the Company issues shares of Common Stock, or options to purchase Common Stock, to any
employee, and the Company desires to make such employee a party to this Agreement as an Additional Stockholder, such employee shall become a party hereto as an Additional Stockholder (without 

  
 - 9 - 

 
the need for an amendment to this Agreement or the consent of any other party hereto) if the Company and such employee execute a counterpart signature page to this Agreement (which counterpart
signature page shall be kept in the Company’s records). The Company shall add the names of such Additional Stockholders to Schedule C. 

(b) The Company shall permit each additional purchaser of Series B Preferred Stock pursuant to the Series B Purchase Agreement to become
party to this Agreement as an Investor by signing a counterpart signature page to this Agreement (which counterpart signature page shall be kept in the Company’s records). The Company shall add the names of such additional investors to
Schedule A. 
 10.10 Side Letter. In the event of a conflict between any of the provisions of this Agreement and the
provisions of that certain letter agreement (as amended from time to time, the “Letter Agreement”), dated on or about November 7, 2013, between the Company and the Bill & Melinda Gates Foundation, the parties hereto
agree that the terms of the Letter Agreement shall control. 
 [Remainder of page intentionally left blank.] 

  
 - 10 - 

 IN WITNESS WHEREOF, the parties hereto have executed this Fourth Amended and Restated Right of
First Refusal and Co-Sale Agreement as of the date first written above. 
  

			
	VISTERRA, INC.
		
	By:	 	  

	Name:	 	
	Title:	 	

 Investors: 
  

													
	MERCK SHARP & DOHME CORP.	 		 		 	
						
	By:	 	  
	 		 		 		 	
	Name:	 		 		 		 		 		 	
	Title:	 		 		 		 		 		 	
			
	 POLARIS VENTURE PARTNERS

FOUNDERS’ FUND V, L.P.
	 		 	POLARIS VENTURE PARTNERS V, L.P.
					
	By:	 	 POLARIS VENTURE
 MANAGEMENT CO. V,
L.L.C.
 its General Partner
	 		 	By:	 	 POLARIS VENTURE
 MANAGEMENT CO. V,
L.L.C.
 its General Partner

							
		 	By:	 	  
	 		 		 	By:	 	  

		 	Name:	 	William Bilodeau	 		 		 	Name:	 	William Bilodeau
		 	Title:	 	Attorney-in-Fact	 		 		 	Title:	 	Attorney-in-Fact
			
	 POLARIS VENTURE PARTNERS SPECIAL

FOUNDERS’ FUND V, L.P.
	 		 	 POLARIS VENTURE PARTNERS

ENTREPRENEURS’ FUND V, L.P.

					
	By:	 	 POLARIS VENTURE
 MANAGEMENT CO. V,
L.L.C.
 its General Partner
	 		 	By:	 	 POLARIS VENTURE
 MANAGEMENT CO. V,
L.L.C.
 its General Partner

							
		 	By:	 	  
	 		 		 	By:	 	  

		 	Name:	 	William Bilodeau	 		 		 	Name:	 	William Bilodeau
		 	Title:	 	Attorney-in-Fact	 		 		 	Title:	 	Attorney-in-Fact

  
 Signature Page to
Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement 

									
	Investors (continued):	 		 		 	
			
	FLAGSHIP VENTURES FUND 2007, L.P.	 		 	FLAGSHIP VENTURES FUND IV, L.P.
					
	By:	 	FLAGSHIP VENTURES GENERAL PARTNER L.L.C.	 		 	By:	 	FLAGSHIP VENTURES GENERAL PARTNER L.L.C.
	Its:	 	General Partner	 		 	Its:	 	General Partner
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	Edwin Kania	 		 	Name:	 	Edwin Kania
	Title:	 	Manager	 		 	Title:	 	Manager
				
	FLAGSHIP VENTURES FUND IV-Rx, L.P.	 		 		 	
					
	By:	 	FLAGSHIP VENTURES GENERAL PARTNER L.L.C.	 		 		 	
	Its:	 	General Partner	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 	Edwin Kania	 		 		 	
	Title:	 	Manager	 		 		 	

  
 Signature Page to
Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement 

 Investors (continued): 
  

									
	ALEXANDRIA EQUITIES, LLC,	 		 		 	
	a Delaware limited liability company	 		 		 	
	
	 By: ALEXANDRIA REAL ESTATE EQUITIES, INC.,

a Maryland corporation, managing member

					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 		 		 		 	
				
	OMEGA CAMBRIDGE SPV, L.P.	 		 		 	
	By: Omega Cambridge SPV GP, LLC	 		 		 	
	its General Partner	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 	Manager	 		 		 	
				
	BILL & MELINDA GATES FOUNDATION	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 		 		 		 	
				
	  
	 		 		 	
	David Arkowitz	 		 		 	
				
	BRIAN J G PEREIRA IRREVOCABLE TRUST	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 	Trustee	 		 		 	
				
	  
	 		 		 	
	James Delaney	 		 		 	
				
	  
	 		 		 	
	Alan L. Crane	 		 		 	

  
 Signature Page to
Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement 

 Investors (continued): 
  

									
	  
	 		 		 	
	Brian J G Pereira	 		 		 	

  
 Signature Page to
Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement 

									
		 	Founders:	 		 	  

		 		 		 	Alan L. Crane
				
		 		 		 	  

		 		 		 	Ram Sasisekharan
				
		 		 		 	The Crane Family Irrevocable Trust – 2002
					
		 		 		 	By:	 	  

		 		 		 	Name:	 	Howard R. Crane
		 		 		 	Title:	 	Trustee
				
		 		 		 	Sasisekharan Family 2006 Irrevocable Trust
					
		 		 		 	By:	 	  

		 		 		 	Name:	 	Kenneth S. Federman
		 		 		 	Title:	 	Trustee
				
		 		 		 	Sasisekharan Parents 2006 Irrevocable Trust
					
		 		 		 	By:	 	  

		 		 		 	Name:	 	Kenneth S. Federman
		 		 		 	Title:	 	Trustee
				
		 		 		 	Narayanasami Parents 2006 Irrevocable Trust
					
		 		 		 	By:	 	  

		 		 		 	Name:	 	Kenneth S. Federman
		 		 		 	Title:	 	Trustee
				
		 		 		 	  

		 		 		 	Mahesh Narayanasami
				
		 		 		 	  

		 		 		 	S. Raguram

  
 Signature Page to
Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement 

 Schedule A 

Investors 
 Alexandria Equities, LLC 

385 E. Colorado Boulevard, Suite 299 
 Pasadena, CA 91101 

Attention: Joel S. Marcus, Chief Executive Officer 
 Fax:
626-578-0770 
 David Arkowitz 
 627 Chestnut Street 

Waban, MA 02468 
 Bill & Melinda Gates Foundation 

P.O. Box 23350 
 Seattle, WA 98102 

Attn: Chief Financial Officer 
 Fax: 206-494-7043 

Brian J G Pereira 
 75 Arlington Street 

Winchester, MA 01890 
 Brian J G Pereira Irrevocable Trust 

75 Arlington Street 
 Winchester, MA 01890 

Alan L. Crane 
 c/o Polaris Venture Partners V, L.P. 

Bay Colony Corporate Center 
 1000 Winter Street, Suite 3350 

Waltham, MA 02457 
 James Delaney 

100 Memorial Drive, Apt. 5-2C 
 Cambridge, MA 02142 

Flagship Ventures Fund 2007, L.P. 
 One Memorial Drive 

7th Floor 

Cambridge, MA 02457 
 Flagship Ventures Fund IV, L.P. 

One Memorial Drive 

7th Floor 

Cambridge, MA 02457 

  
 A-1 

 Flagship Ventures Fund IV-Rx, L.P. 

One Memorial Drive 

7th Floor 

Cambridge, MA 02457 
 Merck Sharp & Dohme Corp. 

One Merck Drive 
 P.O. Box 100 

Whitehouse Station, NJ 08889 
 Attn: Office of the Secretary 

Fax: (908) 735-1214 
 Omega Cambridge SPV, L.P. 

c/o Omega Fund Management (US) Inc. 
 545 Boylston Street, Suite
802 
 Boston, MA 02116 
 Polaris Venture Partners V, L.P. 

Bay Colony Corporate Center 
 1000 Winter Street, Suite 3350 

Waltham, MA 02457 
 Attention: William E. Bilodeau 

Fax: 781.290.0880 
 Polaris Venture Partners Entrepreneurs’
Fund V, L.P. 
 Bay Colony Corporate Center 
 1000 Winter
Street, Suite 3350 
 Waltham, MA 02457 
 Attention: William E.
Bilodeau 
 Fax: 781.290.0880 
 Polaris Venture Partners
Founders’ Fund V, L.P. 
 Bay Colony Corporate Center 

1000 Winter Street, Suite 3350 
 Waltham, MA 02457 

Attention: William E. Bilodeau 
 Fax: 781.290.0880 

Polaris Venture Partners Special Founders’ Fund V, L.P. 

Bay Colony Corporate Center 
 1000 Winter Street, Suite 3350 

Waltham, MA 02457 
 Attention: William E. Bilodeau 

Fax: 781.290.0880 

  
 A-2 

 Schedule B 

Founders 
 Alan L. Crane 

Ram Sasisekharan 
 Crane Family Irrevocable Trust – 2002 

Narayanasami Parents 2006 Irrevocable Trust 
 Mahesh Narayanasami

 Sasisekharan Family 2006 Irrevocable Trust 
 Sasisekharan
Parents 2006 Irrevocable Trust 
 S. Raguram 

  
 B-1 

 Schedule C 

Additional Stockholders 

None. 

  
 C-1 

 AMENDMENT NO. 1 TO 

FOURTH AMENDED AND RESTATED 

RIGHT OF FIRST REFUSAL AND CO-SALE AGREEMENT 

This Amendment No. 1 to Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement (“Amendment”), dated as
of                     , 2014, amends that certain Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement, dated as of May 15,
2014, by and among Visterra, Inc. (the “Company”), and the Investors and Founders named therein (the “ROFR Agreement”). Capitalized terms used and not defined herein shall have the meanings set forth in the ROFR
Agreement. 
 WHEREAS, the Company, certain Investors, certain Founders and certain other parties are entering into an Amended and Restated
Series B Convertible Preferred Stock Purchase Agreement, of even date herewith (the “Series B Preferred Stock Purchase Agreement”), providing for the sale and issuance by the Company of shares of its Series B
Convertible Preferred Stock, $0.01 par value per share (the “Series B Preferred Stock”), and shares of its Common Stock and certain other matters; and 

WHEREAS, (i) the Company, (ii) Founders and Additional Stockholders (taken together) holding at least seventy percent (70%) of
the voting power of the Shares then restricted by the ROFR Agreement, and (iii) Investors holding more than sixty percent (60%) of the voting power of the Stock then held by all of the Investors (collectively, the “Requisite
Parties”) desire to modify the terms of the ROFR Agreement as set forth herein. 
 NOW, THEREFORE, in consideration of the mutual
covenants contained herein and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Company and the undersigned, constituting the Requisite Parties, hereby agree as follows: 

1. Section 6. Section 6 of the ROFR Agreement is hereby deleted in its entirety and replaced with the following: 

“Section 6. Investors’ Secondary Refusal Right. 

6.1 Subject to Section 7.1, each Investor shall have an option, exercisable for a period of 15 days from the date of
delivery of the Investor Notice, to purchase his or its Pro Rata Share (as defined below) of the Remaining Shares for the consideration per Share and on the terms and conditions set forth in the Notice (the “Secondary Refusal
Right”). The Secondary Refusal Right shall be exercised by delivery by such Investor of written notice to the Secretary of the Company. Alternatively, each Investor may, within the same 15 day period, notify the Secretary of the Company of
its desire to participate in the sale of the Shares on the terms set forth in the Notice, and the number of Shares it wishes to sell, which right shall be governed by Section 7. For the purposes of this Agreement, the term “Pro Rata
Share” shall mean that number of shares of 

 
Common Stock equal to the product obtained by multiplying (i) the aggregate number of Offered Shares covered by the Notice (less any Offered Shares purchased by the Company pursuant to its
First Refusal Right) by (ii) a fraction, the numerator of which is the number of shares of Stock owned by the Investor at the time of the sale or transfer and the denominator of which is the total number of shares of Stock owned by all
Investors at the time of the sale or transfer. 
 6.2 In the event the Secondary Refusal Right has been exercised by the
Investors with respect to some but not all of the Remaining Shares, those Investors who have exercised their Secondary Refusal Rights within the 15 day period specified in Section 6.1 shall have an additional option (the “Overallotment
Option”), for a period of five days next succeeding the expiration of such 15 day period, to purchase all or any part of the balance of such Remaining Shares on the terms and conditions set forth in the Notice, which Overallotment Option
shall be exercised by the delivery of written notice to the Secretary of the Company. In the event there are two or more such Investors that choose to exercise the Overallotment Option for a total number of Remaining Shares in excess of the number
available, each such Investor shall be allocated its Overallotment Pro Rata Share. The term “Overallotment Pro Rata Share” with respect to such Investor shall mean that number of shares of Stock equal to the product obtained by
multiplying (i) the aggregate number of Offered Shares not already purchased by the Company and the Investors by (ii) a fraction, the numerator of which is the number of shares of Stock owned by such Investor exercising her, her, or its
Secondary Refusal Right at the time of the sale or transfer and the denominator of which is the total number of shares of Stock owned by all Investors exercising their Secondary Refusal Rights at the time of the sale or transfer. Each Investor
exercising its Secondary Refusal Rights shall be entitled to apportion shares to be purchased among its partners, parents, subsidiaries, or affiliates (including, in the case of a venture capital fund, other venture capital funds that are Affiliated
Entities with such fund), provided that such Investor notifies the Selling Founder and the Company of such allocation. 

6.3 If the options to purchase the Remaining Shares are exercised in full by the Investors, the Company shall immediately
notify all of the exercising Investors of that fact. The closing of the purchase of the Remaining Shares shall take place at the offices of the Company no later than five days after the date of such notice to the Investors.” 

2. Section 8. Section 8 of the ROFR Agreement is hereby deleted in its entirety and replaced with the following: 

“8. Termination of Agreement. This Agreement shall terminate upon the earliest to occur of (i) the closing of
a Qualified IPO (as defined in the Amended and Restated Certificate of Incorporation of the Company (the “Restated Certificate”)), (ii) the closing of a merger, consolidation or similar transaction as described in Article
Fourth, Section 3.2(d) of the Restated Certificate, and (iii) the effective date of the conversion of all of the Preferred Stock into Common Stock.” 

  
 -2- 

 3. Section 10.5(iii). Section 10.5(iii) of the ROFR Agreement is hereby deleted
in its entirety and replaced with the following: 
 “Investors holding more than seventy percent (70%) of the
voting power of the Stock then held by all of the Investors, with each share of Seed Preferred Stock and Series A Preferred Stock having one vote per share and each share of Series B Preferred Stock having 1.25 votes per share for purposes
of such vote, and any such amendment, modification, termination or waiver shall be binding on all parties hereto, regardless of whether such party has consented thereto.” 

4. Section 10.6. Section 10.6 of the ROFR Agreement is hereby deleted in its entirety and replaced with the following: 

“Section 10.6 Complete Agreement; Amendments. All Shares held or acquired by an Investor that is an entity
shall be aggregated with Shares held or acquired by any Affiliated Entity thereof for purposes of determining the availability of any rights under this Agreement, and the exercise of any such rights may be allocated among such Affiliated Entities in
such manner as those Affiliated Entities shall determine.” 
 5. Entire Agreement. The ROFR Agreement, as amended by this
Amendment, together with the other writings referred to in the ROFR Agreement or delivered pursuant thereto which form a part thereof, contain the entire agreement among the parties with respect to the subject matter thereof and amend, restate and
supersede all prior and contemporaneous arrangements or understandings with respect thereto. 
 6. Effectiveness. Upon the
effectiveness of this Amendment, on and after the date hereof, each reference in the ROFR Agreement to “this Agreement,” “hereunder,” “hereof,” “herein” or words of like import, and each reference in the other
documents entered into in connection with the ROFR Agreement, shall mean and be a reference to the ROFR Agreement, as amended hereby. Except as specifically amended above, the ROFR Agreement shall remain in full force and effect and is hereby
ratified and confirmed. 
 7. Governing Law. This Amendment shall be governed by, and construed and enforced in accordance with, the
laws of the state of Delaware without regard to its principles of conflicts of laws. 
 8. Counterpart Signature Pages. This
Amendment may be executed in two or more counterparts, each of which shall be deemed to be an original, but all of which shall be one and the same document. 

[Remainder of page intentionally left blank.] 

  
 -3- 

 IN WITNESS WHEREOF, this Amendment has been executed by the parties hereto as of the day and year
first above written. 
  

									
	The Company:	 		 	VISTERRA, INC.
					
		 		 		 	By:	 	  

		 		 		 	Name:	 	Brian Pereira
		 		 		 	Title:	 	President and Chief Executive Officer
	Investors:	 		 		 	
				
	MERCK SHARP & DOHME CORP.	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 		 		 		 	
			
	POLARIS VENTURE PARTNERS FOUNDERS’ FUND V, L.P.	 		 	POLARIS VENTURE PARTNERS V, L.P.
					
	By:	 	POLARIS VENTURE
MANAGEMENT CO. V, L.L.C.
its General Partner	 		 	By:	 	POLARIS VENTURE
MANAGEMENT CO. V, L.L.C.
its General Partner
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	William Bilodeau	 		 	Name:	 	William Bilodeau
	Title:	 	Attorney-in-Fact	 		 	Title:	 	Attorney-in-Fact
			
	POLARIS VENTURE PARTNERS SPECIAL FOUNDERS’ FUND V, L.P.	 		 	POLARIS VENTURE PARTNERS ENTREPRENEURS’ FUND V, L.P.
					
	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C. its General Partner	 		 	By:	 	POLARIS VENTURE MANAGEMENT CO. V, L.L.C. its General Partner
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	William Bilodeau	 		 	Name:	 	William Bilodeau
	Title:	 	Attorney-in-Fact	 		 	Title:	 	Attorney-in-Fact

  
 [Signature Page to
Amendment No. 1 to 
 Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement] 

									
	Investors (continued):	 		 		 	
			
	FLAGSHIP VENTURES FUND 2007, L.P.	 		 	FLAGSHIP VENTURES FUND IV, L.P.
					
	By:	 	FLAGSHIP VENTURES 2007 GENERAL PARTNER L.L.C.	 		 	By:	 	FLAGSHIP VENTURES FUND IV GENERAL PARTNER L.L.C.
		 	Its: General Partner	 		 		 	Its: General Partner
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	Edwin Kania	 		 	Name:	 	Edwin Kania
	Title:	 	Manager	 		 	Title:	 	Manager
				
	FLAGSHIP VENTURES FUND IV-Rx, L.P.	 		 		 	
					
	By:	 	FLAGSHIP VENTURES FUND IV GENERAL PARTNER L.L.C.	 		 		 	
		 	Its: General Partner	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 	Edwin Kania	 		 		 	
	Title:	 	Manager	 		 		 	

  
 [Signature Page to
Amendment No. 1 to 
 Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement] 

									
	Investors (continued):	 		 		 	
				
	 ALEXANDRIA EQUITIES, LLC,
 a
Delaware limited liability company
	 		 		 	
					
	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, INC.,	 		 		 	
		 	a Maryland corporation, managing member	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 		 		 		 	
				
	OMEGA CAMBRIDGE SPV, L.P.	 		 		 	
					
	By:	 	Omega Cambridge SPV GP, LLC	 		 		 	
		 	its General Partner	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 	Manager	 		 		 	
				
	BILL & MELINDA GATES FOUNDATION	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 		 		 		 	
				
	  
	 		 		 	
	David Arkowitz	 		 		 	
				
	  
	 		 		 	
	James Delaney	 		 		 	
				
	  
	 		 		 	
	Alan L. Crane	 		 		 	

  
 [Signature Page to
Amendment No. 1 to 
 Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement] 

									
	Investors (continued):	 		 		 	
				
	  
	 		 		 	
	Brian J G Pereira	 		 		 	
				
	BRIAN J G PEREIRA IRREVOCABLE TRUST	 		 		 	
					
	By:	 	  
	 		 		 	
	Name:	 		 		 		 	
	Title:	 	Trustee	 		 		 	

  
 [Signature Page to
Amendment No. 1 to 
 Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement] 

									
	Founders:	 		 	  

		 		 		 	Alan L. Crane
				
		 		 		 	  

		 		 		 	Ram Sasisekharan
				
		 		 		 	The Crane Family Irrevocable Trust – 2002
					
		 		 		 	By:	 	  

		 		 		 	Name:	 	Howard R. Crane
		 		 		 	Title:	 	Trustee
			
	Sasisekharan Family 2006 Irrevocable Trust	 		 	Sasisekharan Family 2006 Irrevocable Trust
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	S. Raguram	 		 	Name:	 	Kenneth S. Federman
	Title:	 	Trustee	 		 	Title:	 	Trustee
			
	Sasisekharan Parents 2006 Irrevocable Trust	 		 	Sasisekharan Parents 2006 Irrevocable Trust
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	V. Sasisekharan	 		 	Name:	 	Kenneth S. Federman
	Title:	 	Trustee	 		 	Title:	 	Trustee
			
	Narayanasami Parents 2006 Irrevocable Trust	 		 	Narayanasami Parents 2006 Irrevocable Trust
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	S. Raguram	 		 	Name:	 	Kenneth S. Federman
	Title:	 	Trustee	 		 	Title:	 	Trustee
				
		 		 		 	  

		 		 		 	Mahesh Narayanasami
				
		 		 		 	  

		 		 		 	S. Raguram

  
 [Signature Page to
Amendment No. 1 to 
 Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement] 

 EXHIBIT D 

Form of Proprietary Information and Inventions Agreement 

 INVENTION AND NON-DISCLOSURE AGREEMENT 

This Agreement is made by and between Visterra, Inc., a Delaware corporation (hereinafter referred to collectively with its subsidiaries as
the “Company”), and [insert employee name] (the “Employee”). 
 In consideration of the employment or the
continued employment of the Employee by the Company and the issuance of stock options to the Employee on or about the date hereof, the Company and the Employee agree as follows: 

 

	 	1.	Condition of Employment. 

 The Employee acknowledges that his/her employment, the
continuance of that employment with the Company, and the issuance of stock options to the Employee on or about the date hereof are contingent upon his/her agreement to sign and adhere to the provisions of this Agreement. The Employee further
acknowledges that the nature of the Company’s business is such that protection of its proprietary and confidential information is critical to the business’ survival and success. 

 

	 	2.	Proprietary and Confidential Information. 

 (a) The Employee agrees that all information
and know-how, whether or not in writing, of a private, secret or confidential nature concerning the Company’s business or financial affairs (collectively, “Proprietary Information”) is and shall be the exclusive property of the
Company. By way of illustration, but not limitation, Proprietary Information may include discoveries, inventions, products, product improvements, product enhancements, processes, methods, techniques, formulas, compositions, chemical compounds,
negotiation strategies and positions, projects, developments, plans (including business and marketing plans), research data, clinical data, financial data (including sales costs, profits, pricing methods), personnel data, computer programs
(including software used pursuant to a license agreement), customer, prospect and supplier lists, and contacts at or knowledge of customers or prospective customers of the Company. The Employee will not disclose any Proprietary Information to any
person or entity other than employees of the Company or use the same for any purposes (other than in the performance of his/her duties as an employee of the Company) without written approval by an executive officer of the Company, either during or
after his/her employment with the Company, unless and until such Proprietary Information has become public knowledge without fault by the Employee. While employed by the Company, the Employee will use the Employee’s best efforts to prevent
unauthorized publication or disclosure of any of the Company’s Proprietary Information. 
 (b) The Employee agrees that all disks,
files, documents, letters, memoranda, reports, records, data, sketches, drawings, models, laboratory notebooks, program listings, computer equipment or devices, computer programs or other written, photographic, or other tangible or intangible
material containing Proprietary Information, whether created by the Employee or others, which shall come into his/her custody or possession, shall be and are the exclusive property of the Company to be used by the Employee only in the performance of
his/her duties for the Company and shall not be copied or removed from the Company premises 

 Visterra Invention and Non-Disclosure Agreement 

 

 
except in the pursuit of the business of the Company. All such materials or copies thereof and all tangible property of the Company in the custody or possession of the Employee shall be delivered
to the Company, upon the earlier of (i) a request by the Company or (ii) termination or cessation of his/her employment for any reason. After such delivery, the Employee shall not retain any such materials or copies thereof or any such
tangible property. 
 (c) The Employee agrees that his/her obligations with regard to Proprietary Information, which are set forth in
paragraphs 2(a) and 2(b) above, also extend to such types of information, materials and tangible property of customers of the Company or suppliers to the Company or other third parties who may have disclosed or entrusted the same to the Company or
to the Employee in the course of the Company’s business. 
  

	 	3.	Developments. 

 (a) The Employee will make full and prompt disclosure to the Company of
all discoveries, inventions, improvements, enhancements, processes, methods, techniques, developments, software, and works of authorship or other creative works, whether patentable or not, which are created, made, conceived or reduced to practice by
him/her or under his/her direction or jointly with others during his/her employment by the Company, whether or not during normal working hours or on the premises of the Company (all of which are collectively referred to in this Agreement as
“Developments”). 
 (b) The Employee agrees to assign and does hereby assign to the Company (or any person or entity designated by
the Company) all his/her right, title and interest in and to all Developments and all related patents, patent applications, copyrights and copyright applications. However, this paragraph 3(b) shall not apply to Developments which do not relate
to the business or research and development conducted or planned to be conducted by the Company and which are made and conceived by the Employee not during normal working hours, not on the Company’s premises and not using the Company’s
tools, devices, equipment or Proprietary Information. The Employee understands that, to the extent this Agreement shall be construed in accordance with the laws of any state which precludes a requirement in an employee agreement to assign certain
classes of inventions made by an employee, this paragraph 3(b) shall be interpreted not to apply to any invention which a court rules and/or the Company agrees falls within such classes. The Employee also hereby waives all claims to moral
rights in any Developments. 
 (c) The Employee agrees to cooperate fully with the Company, both during and after his/her employment with
the Company, with respect to the procurement, maintenance and enforcement of copyrights, patents and other intellectual property rights (both in the United States and foreign countries) relating to Developments. The Employee shall sign all papers,
including, without limitation, copyright applications, patent applications, declarations, oaths, formal assignments, assignments of priority rights, and powers of attorney, which the Company may deem necessary or desirable in order to protect its
rights and interests in any Development. The Employee further agrees that if the Company is unable, after reasonable effort, to secure the signature of the Employee on any such papers, any executive officer of the Company shall be entitled to
execute any such papers as the agent and the attorney-in-fact of the Employee, and the Employee hereby irrevocably designates and appoints each executive officer of the Company as 

  
 - 2 - 

 Visterra Invention and Non-Disclosure Agreement 

 

 
his/her agent and attorney-in-fact to execute any such papers on his/her behalf, and to take any and all actions as the Company may deem necessary or desirable in order to protect its rights and
interests in any Development, under the conditions described in this sentence. 
  

	 	4.	Other Agreements. 

 The Employee represents that, except as the Employee has disclosed in
writing to the Company, the Employee is not bound by the terms of any agreement with any previous employer or other party to refrain from using or disclosing any trade secret or confidential or proprietary information in the course of his/her
employment with the Company, to refrain from competing, directly or indirectly, with the business of such previous employer or any other party or to refrain from soliciting employees, customers or suppliers of such previous employer or other party.
The Employee further represents that his/her performance of all the terms of this Agreement and the performance of his/her duties as an employee of the Company do not and will not conflict with or breach any agreement with any prior employer or
other party to which the Employee is a party (including without limitation any nondisclosure or non-competition agreement), and that the Employee will not disclose to the Company or induce the Company to use any confidential or proprietary
information or material belonging to any previous employer or others. 
  

	 	5.	United States Government Obligations. 

 The Employee acknowledges that the Company from
time to time may have agreements with other persons or with the United States Government, or agencies thereof, which impose obligations or restrictions on the Company regarding inventions made during the course of work under such agreements or
regarding the confidential nature of such work. The Employee agrees to be bound by all such obligations and restrictions which are made known to the Employee and to take all action necessary to discharge the obligations of the Company under such
agreements. 
  

	 	6.	Miscellaneous. 

 (a) Equitable Remedies. The restrictions contained in this
Agreement are necessary for the protection of the business and goodwill of the Company and are considered by the Employee to be reasonable for such purpose. The Employee agrees that any breach of this Agreement will cause the Company substantial and
irrevocable damage which is difficult to measure. Therefore, in the event of any such breach or threatened breach, the Employee agrees that the Company, in addition to such other remedies which may be available, shall have the right to obtain an
injunction from a court restraining such a breach or threatened breach and the right to specific performance of the provisions of this Agreement without posting a bond and the Employee hereby waives the adequacy of a remedy at law as a defense to
such relief. 
 (b) Obligations to Third Parties. The Employee acknowledges and represents that this Agreement and the
Employee’s employment with the Company will not violate any continuing obligation the Employee has to any former employer or other third party. 

(c) Disclosure of this Agreement. The Employee hereby authorizes the Company to notify others, including but not limited to customers
of the Company and any of the 

  
 - 3 - 

 Visterra Invention and Non-Disclosure Agreement 

 

 
Employee’s future employers or prospective business associates, of the terms and existence of this Agreement and the Employee’s continuing obligations to the Company hereunder. 

(d) Not Employment Contract. The Employee acknowledges that this Agreement does not constitute a contract of employment, does not imply
that the Company will continue his/her employment for any period of time and does not change the at-will nature of his/her employment. 

(e) Successors and Assigns. This Agreement shall be binding upon and inure to the benefit of both parties and their respective
successors and assigns, including any corporation with which, or into which, the Company may be merged or which may succeed to the Company’s assets or business, provided, however, that the obligations of the Employee are personal and shall not
be assigned by him or her. The Employee expressly consents to be bound by the provisions of this Agreement for the benefit of the Company or any subsidiary or affiliate thereof to whose employ the Employee may be transferred without the necessity
that this Agreement be re-signed at the time of such transfer. 
 (f) Severability. In case any provision of this Agreement shall be
invalid, illegal or otherwise unenforceable, the validity, legality and enforceability of the remaining provisions shall in no way be affected or impaired thereby. 

(g) Waivers. No delay or omission by the Company in exercising any right under this Agreement will operate as a waiver of that or any
other right. A waiver or consent given by the Company on any one occasion is effective only in that instance and will not be construed as a bar to or waiver of any right on any other occasion. 

(h) Governing Law, Forum and Jury Trial Waiver. This Agreement shall be governed by and construed in accordance with the laws of the
Commonwealth of Massachusetts (without reference to the conflicts of laws provisions thereof). Any action, suit, or other legal proceeding which is commenced to resolve any matter arising under or relating to any provision of this Agreement shall be
commenced only in a court of the Commonwealth of Massachusetts (or, if appropriate, a federal court located within Massachusetts), and the Company and the Employee each consents to the jurisdiction of such a court. The Company and the Employee
each hereby irrevocably waive any right to a trial by jury in any action, suit or other legal proceeding arising under or relating to any provision of this Agreement. 

(i) Entire Agreement; Amendment. This Agreement supersedes all prior agreements, written or oral, between the Employee and the Company
relating to the subject matter of this Agreement. This Agreement may not be modified, changed or discharged in whole or in part, except by an agreement in writing signed by the Employee and the Company. The Employee agrees that any change or changes
in his/her duties, salary or compensation after the signing of this Agreement shall not affect the validity or scope of this Agreement. 

(j) Captions. The captions of the sections of this Agreement are for convenience of reference only and in no way define, limit or
affect the scope or substance of any section of this Agreement. 

  
 - 4 - 

 Visterra Invention and Non-Disclosure Agreement 

 

 (k) Return of Property. Upon termination or cessation of the Employee’s
employment with the Company for any reason or at the Company’s request, the Employee agrees to return to the Company any and all property of the Company’s in the Employee’s possession, custody or control, including, but not limited
to, all keys, files, records, and equipment (including, but not limited to, computer hardware, software, printers, wireless handheld devices, cellular phones, etc.). 

THE EMPLOYEE ACKNOWLEDGES THAT HE/SHE HAS CAREFULLY READ THIS AGREEMENT AND UNDERSTANDS AND AGREES TO ALL OF THE PROVISIONS IN THIS AGREEMENT.

 WITNESS our hands and seals: 
  

							
		 		 	VISTERRA, INC.
				
	Date:                     	 		 	By:	 	  

		 		 		 	[insert name and title]
			
		 		 	[EMPLOYEE NAME]
			
		 		 	  

	Date:                     	 		 	(Signature)

  
 - 5 - 

 EXHIBIT E 

Form of Legal Opinion 

 EXHIBIT F 

Form of Indemnification Agreement 

 DIRECTOR INDEMNIFICATION AGREEMENT 

THIS INDEMNIFICATION AGREEMENT (“Agreement”) is made as of
                        , 2014, by and between VISTERRA, INC., a Delaware corporation (the
“Company”), and                                  (the
“Indemnitee”). 
 WHEREAS, the Company desires to attract and retain the services of highly qualified
individuals, such as Indemnitee, to serve as directors on the Company’s Board of Directors and to indemnify its directors so as to provide them with the maximum protection permitted by law. 

WHEREAS, the Board of Directors of the Company (the “Board”) has determined that, in order to attract and retain
qualified individuals, the Company will attempt to maintain on an ongoing basis, at its sole expense, liability insurance to protect persons serving the Company and its subsidiaries from certain liabilities. Although the furnishing of such insurance
has been a customary and widespread practice among United States-based corporations and other business enterprises, the Company believes that, given current market conditions and trends, such insurance may be available to it in the future only at
higher premiums and with more exclusions. At the same time, directors, officers, and other persons in service to corporations or business enterprises are being increasingly subjected to expensive and time-consuming litigation relating to, among
other things, matters that traditionally would have been brought only against the Company or business enterprise itself. The Certificate of Incorporation of the Company requires indemnification of the officers and directors of the Company.
Indemnitee may also be entitled to indemnification pursuant to the General Corporation Law of the State of Delaware (“DGCL”). The Certificate of Incorporation and the DGCL expressly provide that the indemnification provisions set
forth therein are not exclusive, and thereby contemplate that contracts may be entered into between the Company and members of the Board, officers and other persons with respect to indemnification; 

WHEREAS, the uncertainties relating to such insurance and to indemnification have increased the difficulty of attracting and retaining
such persons; 
 WHEREAS, the Board has determined that the increased difficulty in attracting and retaining such persons is
detrimental to the best interests of the Company’s stockholders and that the Company should act to assure such persons that there will be increased certainty of such protection in the future; 

WHEREAS, it is reasonable, prudent and necessary for the Company contractually to obligate itself to indemnify, and to advance expenses
on behalf of, such persons to the fullest extent permitted by applicable law so that they will serve or continue to serve the Company free from undue concern that they will not be so indemnified; 

WHEREAS, this Agreement is a supplement to and in furtherance of the Certificate of Incorporation of the Company and any resolutions
adopted pursuant thereto, and shall not be deemed a substitute therefor, nor to diminish or abrogate any rights of Indemnitee thereunder; and 

 WHEREAS, Indemnitee does not regard the protection available under the Company’s
Certificate of Incorporation and insurance as adequate in the present circumstances, and may not be willing to serve as a director without adequate protection, and the Company desires Indemnitee to serve in such capacity. Indemnitee is willing to
serve, continue to serve and to take on additional service for or on behalf of the Company on the condition that he or she be so indemnified. 

NOW, THEREFORE, in consideration of Indemnitee’s agreement to serve as a director of the Company and
other good and valuable consideration, Company and Indemnitee hereby agree as follows: 
 1. Indemnification. The Company shall
indemnify, defend, and hold harmless Indemnitee from and against, and shall compensate and reimburse Indemnitee for, any Damages (as defined below) that are directly or indirectly suffered or incurred by Indemnitee as a result of, or are directly or
indirectly connected with, any threatened, pending or completed action or proceeding, whether civil, criminal, administrative or investigative, to which Indemnitee is or was a party, or is threatened to be made a party, by reason of, or arising
directly or indirectly from, the fact that Indemnitee is or was a member of the Company’s Board or the board of directors of any subsidiary of the Company, by reason of any action or inaction on the part of Indemnitee in his role as a member of
the Company’s Board or by reason of the fact that Indemnitee is or was serving at the request of the Company as a director, officer, employee or agent of the Company or of another corporation, partnership, joint venture, trust or other
enterprise, provided however, that the Company shall not be obligated to indemnify Indemnitee under this Section 1: (1) if the Company can demonstrate that Indemnitee acted in bad faith and in a manner Indemnitee could not
reasonably have believed to be in or not opposed to the best interests of the Company, and, with respect to any criminal action or proceeding, that Indemnitee had no reasonable cause to believe Indemnitee’s conduct was lawful; or (2) in an
action by or in the right of the Company, for any claim, issue or matter as to which Indemnitee shall have been adjudged to be liable to the Company in the performance of any duty to the Company and its shareholders unless and only to the extent
that the court in which such action or proceeding is or was pending shall determine upon application that, in view of all the circumstances of the case, Indemnitee is fairly and reasonably entitled to indemnity for expenses and then only to the
extent that the court shall determine. The termination of any action or proceeding by judgment, order, settlement, conviction, or upon a plea of nolo contendere or its equivalent, shall not, of itself, create a presumption that
(i) Indemnitee did not act in good faith, (ii) Indemnitee did not act in a manner which Indemnitee reasonably believed to be in the best interests of the Company, or (iii) with respect to any criminal action or proceeding, Indemnitee
had reasonable cause to believe that Indemnitee’s conduct was unlawful. “Damages” shall include any loss, damage, injury, liability, claim, demand, settlement, judgement, award, fine, penalty, tax, fee (including any legal fee, expert
fee, accounting fee or advisory fee), charge, cost (including any cost of investigation) or expense of any nature. 
 2. Expenses;
Indemnification Procedure. 
 (a) Advancement of Expenses. The Company shall advance all expenses incurred by Indemnitee in
connection with the investigation, defense, settlement or appeal of any civil or criminal action or proceeding referenced in Section 1 hereof (but not amounts actually paid 

  
 -2- 

 
in settlement of any such action or proceeding). Indemnitee hereby undertakes to repay such amounts advanced only if, and to the extent that, it shall ultimately be determined such expenses were
not reasonable or that Indemnitee is not entitled to be indemnified by the Company as authorized hereby. The advances to be made hereunder shall be paid by the Company to Indemnitee within twenty (20) days following delivery of a written
request therefor by Indemnitee to the Company. 
 (b) Notice/Cooperation by Indemnitee. Indemnitee shall, as a condition precedent to
his right to be indemnified under this Agreement, give the Company notice in writing as soon as practicable of any claim made against Indemnitee for which indemnification will or could be sought under this Agreement. Notice to the Company shall be
directed to the Secretary of the Company at the address shown on the signature page of this Agreement (or such other address as the Company shall designate in writing to Indemnitee). In addition, Indemnitee shall give the Company such information
and cooperation as it may reasonably require and as shall be within Indemnitee’s power. 
 (c) Procedure. Any indemnification
provided for in Section 1 shall be made no later than forty-five (45) days after receipt of the written request of Indemnitee. If a claim under this Agreement, under any statute, or under any provision of the Company’s Certificate of
Incorporation or Bylaws providing for indemnification, is not paid in full by the Company within forty-five (45) days after a written request for payment thereof has first been received by the Company, Indemnitee may, but need not, at any time
thereafter bring an action against the Company to recover the unpaid amount of the claim and, subject to Section 13 of this Agreement, Indemnitee shall also be entitled to be paid for the expenses (including attorneys’ fees) of bringing
such action. It shall be a defense to any such action (other than an action brought to enforce a claim for expenses incurred in connection with any action or proceeding in advance of its final disposition) that Indemnitee has not met the standards
of conduct which make it permissible under applicable law for the Company to indemnify Indemnitee for the amount claimed, but the burden of proving such defense shall be on the Company, and Indemnitee shall be entitled to receive interim payments of
expenses pursuant to Subsection 2(a) unless and until such defense may be finally adjudicated by court order or judgment from which no further right of appeal exists. It is the parties’ intention that if the Company contests Indemnitee’s
right to indemnification, the question of Indemnitee’s right to indemnification shall be for the court to decide, and neither the failure of the Company (including its Board of Directors, any committee or subgroup of the Board of Directors,
independent legal counsel, or its shareholders) to have made a determination that indemnification of Indemnitee is proper in the circumstances because Indemnitee has met the applicable standard of conduct required by applicable law, nor an actual
determination by the Company (including its Board of Directors, any committee or subgroup of the Board of Directors, independent legal counsel, or its shareholders) that Indemnitee has not met such applicable standard of conduct, shall create a
presumption that Indemnitee has or has not met the applicable standard of conduct. 
 (d) Selection of Counsel. In the event the
Company shall be obligated under Section 2(a) hereof to pay the expenses of any proceeding against Indemnitee, the Company, if appropriate, shall be entitled to assume the defense of such proceeding, with counsel approved by Indemnitee, which
approval shall not be unreasonably withheld, upon the delivery to Indemnitee of 

  
 -3- 

 
written notice of its election so to do. After delivery of such notice, approval of such counsel by Indemnitee and the retention of such counsel by the Company, the Company will not be liable to
Indemnitee under this Agreement for any fees of counsel subsequently incurred by Indemnitee with respect to the same proceeding, provided that (i) Indemnitee shall have the right to employ his counsel in any such proceeding at
Indemnitee’s expense; and (ii) if (A) the employment of counsel by Indemnitee has been previously authorized by the Company, (B) Indemnitee shall have reasonably concluded that there may be a conflict of interest on any
significant issue between the Company and Indemnitee in the conduct of any such defense or (C) the Company shall not, in fact, have employed counsel to assume the defense of such proceeding, then the fees and expenses of Indemnitee’s
counsel shall be at the expense of the Company. 
 3. Additional Indemnification Rights; Nonexclusivity; Primacy of Indemnification.

 (a) Scope. Notwithstanding any other provisions of this Agreement, the Company hereby agrees to indemnify the Indemnitee to the
fullest extent permitted by law, notwithstanding that such indemnification is not specifically authorized by the other provisions of this Agreement, the Company’s Certificate of Incorporation, the Company’s Bylaws or by statute. In the
event of any change, after the date of this Agreement, in any applicable law, statute or rule which expands the right of a Delaware corporation to indemnify a member of its Board, such changes shall be, ipso facto, within the purview of
Indemnitee’s rights and Company’s obligations, under this Agreement. In the event of any change in any applicable law, statute or rule which narrows the right of a Delaware corporation to indemnify a member of its Board, such changes, to
the extent not otherwise required by such law, statute or rule to be applied to this Agreement shall have no effect on this Agreement or the parties’ rights and obligations hereunder. 

(b) Nonexclusivity. The indemnification provided by this Agreement shall not be deemed exclusive of any rights to which Indemnitee may
be entitled under the Company’s Certificate of Incorporation, its Bylaws, any agreement, any vote of shareholders or disinterested directors, Delaware law, or otherwise, both as to action in Indemnitee’s official capacity and as to action
in another capacity while holding such office. The indemnification provided under this Agreement shall continue as to Indemnitee for any action taken or not taken while serving in an indemnified capacity even though he may have ceased to serve in
such capacity at the time of any action or otherwise covered proceeding. 
 (c) Primacy of Indemnification. The Company hereby
acknowledges that Indemnitee has or may have certain rights to indemnification, advancement of expenses and/or insurance provided by other entities with which Indemnitee is affiliated and certain of its affiliates (collectively, the
“Indemnitors”). The Company hereby agrees (i) that it is the indemnitor of first resort (i.e., its obligations to Indemnitee are primary and any obligation of the Indemnitors to advance expenses or to provide indemnification
for the same expenses or liabilities incurred by Indemnitee are secondary); (ii) that it shall be required to advance the full amount of expenses incurred by Indemnitee and shall be liable for the full amount of all expenses, judgments,
penalties, fines and amounts paid in settlement to the extent legally permitted and as required by the terms of this Agreement and the Certificate of Incorporation or Bylaws of the Company (or any other agreement between the Company and Indemnitee),
without regard to any rights Indemnitee may 

  
 -4- 

 
have against the Indemnitors; and (iii) that it irrevocably waives, relinquishes and releases the Indemnitors from any and all claims against the Indemnitors for contribution, subrogation or
any other recovery of any kind in respect thereof. The Company further agrees that no advancement or payment by the Indemnitors on behalf of Indemnitee with respect to any claim for which Indemnitee has sought indemnification from the Company shall
affect the foregoing and the Indemnitors shall have a right of contribution and/or be subrogated to the extent of such advancement or payment to all of the rights of recovery of Indemnitee against the Company. The Company and Indemnitee agree that
the Indemnitors are express third party beneficiaries of the terms of this Section 3(c). 
 4. Partial Indemnification. If
Indemnitee is entitled under any provision of this Agreement to indemnification by the Company for some or a portion of the expenses, judgments, fines or penalties actually or reasonably incurred by him in the investigation, defense, appeal or
settlement of any civil or criminal action or proceeding, but not, however, for the total amount thereof, the Company shall nevertheless indemnify Indemnitee for the portion of such expenses, judgments, fines or penalties to which Indemnitee is
entitled. 
 5. Indemnification of an Entity. If (i) Indemnitee is or was affiliated with one or more entities that has invested
in the Company (each an “Entity”), (ii) an Entity is, or is threatened to be made, a party to or a participant in any threatened, pending or completed action, suit, arbitration, alternative dispute resolution mechanism,
investigation, inquiry, administrative hearing or any other actual, threatened or completed proceeding, whether brought by or in the right of the Company or otherwise and whether civil, criminal, administrative or investigative, and (iii) the
Entity’s involvement in such matter is (A) directly or indirectly related to Indemnitee’s service to the Company as a director of the Company or (B) based in whole or in part on facts and circumstances that are the basis for any
Proceeding against the Indemnitee, then the Entity shall be entitled to all of the indemnification rights and remedies under this Agreement to the same extent as Indemnitee; provided, however, that (x) any such indemnification shall be subject
to the same limitations as set forth in Section 1 or otherwise herein; and (y) no such indemnification shall be available to any Entity (or affiliate) in the event that Indemnitee shall not be entitled to indemnification in the same or any
related action or proceeding. The terms of this Agreement as they relate to procedures for indemnification of Indemnitee shall apply to any such indemnification of Entity and its affiliates. The provisions of this Section 5 are intended for the
benefit of, and are enforceable by, each Entity and are in addition to, and not in substitution of, any other rights that may be available to an Entity under applicable law or otherwise. 

6. Mutual Acknowledgment. Both the Company and Indemnitee acknowledge that in certain instances, Federal law or applicable public
policy may prohibit the Company from indemnifying its directors, officers or other advisors under this Agreement or otherwise. Indemnitee understands and acknowledges that the Company has undertaken or may be required in the future to undertake with
the Securities and Exchange Commission to submit the question of indemnification to a court in certain circumstances for a determination of the Company’s right under public policy to indemnify Indemnitee. 

7. Severability. Nothing in this Agreement is intended to require or shall be construed as requiring the Company to do or fail to do
any act in violation of applicable law. The Company’s 

  
 -5- 

 
inability, pursuant to court order, to perform its obligations under this Agreement shall not constitute a breach of this Agreement. The provisions of this Agreement shall be severable as
provided in this Section 7. If this Agreement or any portion hereof shall be invalidated on any ground by any court of competent jurisdiction, then the Company shall nevertheless indemnify Indemnitee to the full extent permitted by any
applicable portion of this Agreement that shall not have invalidated, and the balance of this Agreement not so invalidated shall be enforceable in accordance with its terms. 

8. Exceptions. Any other provision herein to the contrary notwithstanding, the Company shall not be obligated pursuant to the terms of
this Agreement to indemnify Indemnitee or to advance expenses in connection with any claim made against Indemnitee: 
 (a) Excluded
Acts. Any acts or omissions or transactions from which a director may not be relieved of liability under Delaware Law; 
 (b) Claims
Initiated by Indemnitee. With respect to proceedings or claims initiated or brought voluntarily by Indemnitee and not by way of defense, except with respect to proceedings brought to establish or enforce a right to indemnification under this
Agreement or any other statute or law, but such indemnification or advancement of expenses may be provided by the Company in specific cases if the Board of Directors has approved the initiation or bringing of such suit; 

(c) Lack of Good Faith. For any expenses incurred by the Indemnitee with respect to any proceeding instituted by Indemnitee to enforce
or interpret this Agreement, if a court of competent jurisdiction determines that each of the material assertions made by the Indemnitee in such proceeding was not made in good faith or was frivolous; 

(d) Claims Under Section 16(b). For expenses and the payment of profits arising from the purchase and sale by Indemnitee of
securities in violation of Section 16(b) of the Securities Exchange Act of 1934, as amended, or any similar successor statute; 

(e) Insurance Payments. To the extent that payment is actually made to the Indemnitee under a valid, enforceable and collectible
insurance policy of the Company, and in the event the Company makes any indemnification payments to the Indemnitee and the Indemnitee is subsequently reimbursed from the proceeds of insurance, the Indemnitee will promptly refund such indemnification
payments to the Corporation to the extent of such insurance reimbursement; or 
 (f) Judicial Determination. In connection with a
judicial action by or in the right of the Company, in respect of any claim, issue or matter as to which the Indemnitee shall have been adjudged to be liable in the performance of his duty to the Company unless and only to the extent that any court
in which such action was brought shall determine upon application that, despite the adjudication of liability but in view of all the circumstances of the case, the Indemnitee is fairly and reasonably entitled to indemnity for such expenses as such
court shall deem proper. 
 9. Effectiveness of Agreement. To the extent that the indemnification permitted under the terms of
certain provisions of this Agreement exceeds the scope of the indemnification provided for under Delaware law, such provisions shall not be effective unless and until the Company’s 

  
 -6- 

 
Certificate of Incorporation authorizes such additional rights of indemnification. In all other respects, the balance of this Agreement shall be effective as of the date set forth on the first
page. 
 10. Construction of Certain Phrases. 

(a) For purposes of this Agreement, references to the “Company” shall include, in addition to the resulting corporation, any
constituent corporation (including any constituent of a constituent) absorbed in a consolidation or merger which, if its separate existence had continued, would have had power and authority to indemnify its directors, officers, employees or agents,
so that if Indemnitee is or was a director, officer, employee or agent of another corporation, partnership, joint venture, trust or other enterprise, Indemnitee shall stand in the same position under the provisions of this Agreement with respect to
the resulting or surviving corporation as Indemnitee would have with respect to such constituent corporation if its separate existence had continued. 

(b) For purposes of this Agreement, references to “other enterprises” shall include employee benefit plans; references to
“fines” shall include any excise taxes assessed on Indemnitee with respect to an employee benefit plan; and references to “serving at the request of the Company” shall include any service as a director, officer, employee or agent
of the Company which imposes duties on, or involves services by, such director, officer, employee or agent with respect to an employee benefit plan, its participants, or beneficiaries. 

11. Counterparts. This Agreement may be executed in one or more counterparts, each of which shall constitute an original. 

12. Successors and Assigns. This Agreement shall be binding upon the Company and its successors and assigns, and shall inure to the
benefit of Indemnitee and Indemnitee’s estate, heirs, legal representatives and assigns. 
 13. Attorneys’ Fees. In the
event that any action is instituted by Indemnitee under this Agreement to enforce or interpret any of the terms hereof, Indemnitee shall be entitled to be paid all court costs and expenses, including reasonable attorneys’ fees, incurred by
Indemnitee with respect to such action, unless as a part of such action, the court of competent jurisdiction determines that each of the material assertions made by Indemnitee as a basis for such action were not made in good faith or were frivolous.
In the event of an action instituted by or in the name of the Company under this Agreement or to enforce or interpret any of the terms of this Agreement, Indemnitee shall be entitled to be paid all court costs and expenses, including attorneys’
fees, incurred by Indemnitee in defense of such action (including with respect to Indemnitee’s counterclaims and cross-claims made in such action), unless as a part of such action the court determines that each of Indemnitee’s material
defenses to such action were made in bad faith or were frivolous. 
 14. Notices. All notices, requests, demands and other
communications under this Agreement shall be in writing and shall be deemed duly given (i) if delivered by hand and receipted for by the party addressee, on the date of such receipt, or (ii) if mailed by domestic certified or registered
mail, properly addressed with postage prepaid, on the third business day after the date postmarked; otherwise a notice shall be deemed duly given when such notice shall be actually 

  
 -7- 

 
received by the addressee. Addresses for notice to either party are as shown on the signature page of this Agreement, or as subsequently modified by written notice. 

15. Choice of Law. This Agreement shall be governed by and its provisions construed in accordance with the laws of the State of
Delaware as applied to contracts between Delaware residents entered into and to be performed entirely within Delaware. 

  
 -8- 

 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date first
above written. 
 AGREED TO AND ACCEPTED 
  

									
	INDEMNITEE:	 		 		 	COMPANY:
			
	  
	 		 	  

		 		 	By:	 	Brian Pereira
		 		 		 	Title:	 	President and Chief Executive Officer
	Address:	 		 	Address:
			
		 		 	One Kendall Square, Suite B3301
		 		 	Cambridge, MA 02139
		 		 	Attn: Brian Pereira
		 		 	Fax: (617) 498-1073

 [Signature Page to Indemnification Agreement] 

 VISTERRA, INC. 

DISCLOSURE SCHEDULE 

September 12, 2014 

This Disclosure Schedule is furnished by Visterra, Inc., a Delaware corporation (the “Company”), pursuant to the Amended and
Restated Series B Convertible Preferred Stock Purchase Agreement, dated as of the date hereof (the “Agreement”), by and among the Company and the Founder Holders, Preferred Holders and Purchasers named therein. Any capitalized terms used
herein but not defined herein shall have the meanings ascribed thereto in the Agreement. 
 This Disclosure Schedule is arranged in sections
and subsections corresponding to the numbered and lettered sections and subsections contained in Section 2 of the Agreement. The disclosures in any section of subsection of this Disclosure Schedule shall qualify the corresponding section and/or
subsection of Section 2 of the Agreement and shall also qualify other sections and subsections in Section 2 to the extent it is readily apparent from a reading of the disclosure that such disclosure is applicable to such other sections and
subsections. This Disclosure Schedule shall not be deemed to expand in any way the scope or effect of any of such representations and warranties. 

Certain information contained in this Disclosure Schedule is confidential, proprietary information of the Company. 

 

	Section 2.5	Capitalization. 

 Subsection 2.5(f) 

Rights pursuant to the 2008 Patent License Agreement 

Pursuant to the 2008 Patent License Agreement, until such date as the Company received an aggregate of $5,000,000 in cash in exchange for its capital stock
(the “Funding Threshold Date”), the Company was obligated to issue MIT and/or such persons as MIT directed additional shares of Common Stock from time to time as necessary to enable them to continue holding five percent (5%) of the
Company’s capital stock on a Fully Diluted Basis (as defined in the 2008 Patent License Agreement). The Funding Threshold Date occurred on September 3, 2010. 

MIT has the right to participate in future offerings of the Company’s equity securities, in each case subject to certain exceptions and according to
terms and conditions set forth in the 2008 Patent License Agreement. 

 Warrants 

Warrant to purchase 250,000 shares of Common Stock issued to the Massachusetts Institute of Technology (“MIT”) on April 28, 2008. Effective as
of January 25, 2013, MIT transferred the right to purchase 37,500 of the shares of Common Stock subject to this Warrant to Omega Cambridge SPV, LP. 

Warrant to purchase 250,000 shares of Common Stock issued to MIT for the benefit of the Sasisekharan Laboratories on April 28, 2008. Effective as of
January 25, 2013, MIT transferred the right to purchase 37,500 of the shares of Common Stock subject to this Warrant to Omega Cambridge SPV, LP. 

Warrant to purchase 25,000 shares of Seed Stock issued to Lighthouse Capital Partners VI, L.P. on February 28, 2011. 

Warrant to purchase 62,500 shares of Seed Stock issued to Lighthouse Capital Partners VI, L.P. on September 30, 2011. 

Warrant to purchase 1,151,801 shares of Common Stock issued to Polaris Venture Partners V, L.P. on May 14, 2012. 

Warrant to purchase 22,448 shares of Common Stock issued to Polaris Venture Partners Entrepreneurs’ Fund V, L.P. on May 14, 2012. 

Warrant to purchase 7,890 shares of Common Stock issued to Polaris Venture Partners Founders’ Fund V, L.P. on May 14, 2012. 

Warrant to purchase 11,518 shares of Common Stock issued to Polaris Venture Partners Special Founders’ Fund V, L.P. on May 14, 2012. 

Warrant to purchase 1,186,623 shares of Common Stock issued to Flagship Ventures Fund 2007, L.P. on May 14, 2012. 

Warrant to purchase 80,000 shares of Series B Preferred Stock and 20,000 shares of Common Stock issued to Oxford Finance LLC on September 9, 2014 

Warrant to purchase 80,000 shares of Series B Preferred Stock and 20,000 shares of Common Stock issued to Square 1 Bank on September 9, 2014 

Pursuant to the Loan and Security Agreement dated September 9, 2014 between the Company and Oxford Finance LLC and Square 1 Bank (the
“Lenders”), the Company has agreed to issue to the Lenders warrants exercisable for the class of preferred stock issued in the Company’s most recent preferred stock financing prior to the date of issuance of the warrant, with an
exercise price equal to the lowest price per share at which shares of such class of preferred stock were issued in such financing. The number of warrants to be issued will be equal to 4.0% of the aggregate principal amount of the terms loans funded
on the date of such issuance, divided by 

  
 - 2 - 

 
such warrant price. As of the date hereof, the Company has $5.0 million in available term loan funding under the Loan and Security Agreement. 

There are outstanding options to purchase 9,061,703 shares of Common Stock, which were granted to employees and directors of, and consultants to, the Company,
as follows: 
  

					
	 Employees
	  			
	 Zachary Shriver
	  	 	700,000	  
	 Karthik Viswanathan
	  	 	41,875	  
	 Hedy Adari
	  	 	35,000	  
	 Jennifer Dupee
	  	 	18,000	  
	 James Delaney
	  	 	12,650	  
	 Tyree Koch
	  	 	11,250	  
	 David Eavarone
	  	 	21,146	  
	 Bi Xu
	  	 	35,000	  
	 Yadunanda Budigi
	  	 	34,000	  
	 Kristy Szretter
	  	 	27,125	  
	 Luke Robinson
	  	 	26,250	  
	 Wilton DePina
	  	 	2,250	  
	 Sunny Himansu
	  	 	3,750	  
	 James Myette
	  	 	50,000	  
	 Greg Babcock
	  	 	62,500	  
	 Susan Sloan
	  	 	50,000	  
	 Hamid Tissire
	  	 	8,000	  
	 Kirk Rowley
	  	 	8,000	  
	 Brian Pereira
	  	 	6,022,500	  
	 Catherine Hay
	  	 	50,000	  
	 David Arkowitz
	  	 	1,053,803	  
	 Greg Miller
	  	 	421,521	  
	 Boopathy Ramakrishnan
	  	 	30,000	  
	 Obadiah Plante
	  	 	50,000	  
	 Andrew Wolacott
	  	 	28,000	  
	 Andrew Walsh
	  	 	5,000	  
		  	  
	  
	 
	 Total Employees
	  	 	8,807,620	  
		  	  
	  
	 
	 Consultants
	  			
	 Bob Gerety
	  	 	25,000	  
	 S Raguram
	  	 	10,000	  
	 Mark Boshar
	  	 	72,500	  
	 Raphael Dolin
	  	 	42,000	  
	 Steven Tannenbaum
	  	 	28,000	  
	 George Siber
	  	 	26,583	  
	 Willaim Cervino
	  	 	37,500	  
	 Mark Kesic
	  	 	12,500	  
		  	  
	  
	 
	 Total Consultants
	  	 	254,083	  
		  	  
	  
	 

  
 - 3 - 

 Subsection 2.5(g)(i) 

The security holders of the Company include the option and warrant holders listed above. The stockholders of the Company immediately prior to the Second
Closing are as follows: 
  

																	
	 	  	Outstanding
Common Stock	 	  	Seed Conv.
Preferrred Stock	 	  	Series A Conv.
Preferred Stock	 	  	Series B Conv.
Preferred Stock	 
	 Steven Brugger
	  	 	750,000	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Delaney, James
	  	 	23,000	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Sanjay K Sehgal
	  	 	12,500	  	  	 	0	  	  	 	0	  	  	 	0	  
	 April Blodgett
	  	 	12,812	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Vidya Subramanian
	  	 	16,671	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Kamran Tavanger
	  	 	125,833	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Crane Family Irrevocable Trust - 2002
	  	 	1,126,249	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Crane, Alan L.
	  	 	273,751	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Sasisekharan, Ram
	  	 	2,500,000	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Sasisekharan Family 2006 Irrevocable Trust
	  	 	1,000,000	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Sasisekharan Parents 2006 Irrevocable Trust
	  	 	200,000	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Narayanasami Parents 2006 Irrevocable Trust
	  	 	50,000	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Narayanasami, Mahesh
	  	 	50,000	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Raguram, S.
	  	 	218,205	  	  	 	0	  	  	 	0	  	  	 	0	  
	 MIT
	  	 	425,359	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Rahul Raman
	  	 	31,985	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Viswanathan Sasisekharan
	  	 	17,035	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Aarthia Chandrasekharan
	  	 	15,866	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Aravind Srinivasan
	  	 	15,866	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Karthik Viswanathan
	  	 	18,205	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Ganpan Gao
	  	 	5,512	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Venkataramanan Soundaraajan
	  	 	1,170	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Mahadevan Venkataraman
	  	 	1,170	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Zachary Shriver
	  	 	1,170	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Ramasubramanian Kaundinya
	  	 	1,170	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Akila Jayaraman
	  	 	1,170	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Polaris Venture Partners Entrepreneurs’ Fund V, L.P.
	  	 	0	  	  	 	67,058	  	  	 	224,704	  	  	 	54,236	  
	 Polaris Venture Partners Founders’ Fund V, L.P.
	  	 	0	  	  	 	23,569	  	  	 	78,976	  	  	 	19,062	  
	 Polaris Venture Partners Special Founders’ Fund V, L.P.
	  	 	0	  	  	 	34,408	  	  	 	115,295	  	  	 	27,828	  
	 Polaris Venture Partners V, L.P.
	  	 	0	  	  	 	3,440,678	  	  	 	11,529,311	  	  	 	2,782,783	  
	 Flagship Ventures Fund 2007, L.P.
	  	 	0	  	  	 	2,525,713	  	  	 	8,338,786	  	  	 	0	  
	 Flagship Ventures Fund IV, L.P.
	  	 	0	  	  	 	0	  	  	 	2,000,000	  	  	 	2,092,890	  
	 Flagship Ventures Fund IV-Rx, L.P.
	  	 	0	  	  	 	0	  	  	 	500,000	  	  	 	523,223	  
	 Lux Ventures II Sidecar, L.P.
	  	 	99,018	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Lux Ventures II, L.P.
	  	 	2,380,597	  	  	 	0	  	  	 	0	  	  	 	0	  
	 Gates Foundation
	  	 	0	  	  	 	0	  	  	 	6,800,000	  	  	 	0	  
	 Omega Cambridge SPV, L.P.
	  	 	75,063	  	  	 	0	  	  	 	1,700,000	  	  	 	383,315	  
	 Merck Sharp & Dohme Corp.
	  	 	0	  	  	 	0	  	  	 	0	  	  	 	6,000,000	  
	 Crane, Alan L.
	  	 	0	  	  	 	0	  	  	 	350,000	  	  	 	0	  
	 Alexandria Equities, LLC
	  	 	0	  	  	 	0	  	  	 	339,999	  	  	 	76,663	  
	 Brian J G Pereira
	  	 	0	  	  	 	0	  	  	 	0	  	  	 	40,000	  
	 Brian J G Pereira Irrevocable Trust
	  	 	0	  	  	 	0	  	  	 	150,000	  	  	 	0	  
	 Jim Delaney
	  	 	0	  	  	 	0	  	  	 	250,000	  	  	 	0	  
	 David Arkowitz
	  	 	0	  	  	 	0	  	  	 	70,000	  	  	 	0	  
		  	  
	  
	 	  	  
	  
	 	  	  
	  
	 	  	  
	  
	 
	 Total
	  	 	9,449,377	  	  	 	6,091,426	  	  	 	32,447,072	  	  	 	12,000,000	  
		  	  
	  
	 	  	  
	  
	 	  	  
	  
	 	  	  
	  
	 

  
 - 4 - 

 Subsection 2.5(g)(ii) 

Amended and Restated Letter Agreement, dated November 7, 2013, between the Company and the Bill & Melinda Gates Foundation, as amended on
September 4, 2014 
 Restricted Stock Agreement dated December 20, 2007 between the Company and Alan L. Crane. 

Restricted Stock Agreement dated December 20, 2007 between the Company and Ram Sasisekharan. 

Letter Agreement dated December 28, 2007 between Alan L. Crane, the Company and The Crane Family Irrevocable Trust – 2002. 

Letter Agreements dated December 28, 2007 between Ram Sasisekharan, the Company and each of the following parties: 

 

	 	•	 	the Sasisekharan Family 2006 Irrevocable Trust 

  

	 	•	 	the Sasisekharan Parents 2006 Irrevocable Trust 

  

	 	•	 	the Narayanasami Parents 2006 Irrevocable Trust 

  

	 	•	 	S. Raguram 

  

	 	•	 	Mahesh Narayanasami. 

 Common Stock Issuance Agreements dated May 18, 2010 between the Company and each of
the following parties: 
  

	 	•	 	Massachusetts Institute of Technology 

  

	 	•	 	Venkataramanan Soundararajan 

  

	 	•	 	Mahadevan Venkataraman 

  

	 	•	 	Aravind Srinivasan 

  

	 	•	 	Zachary Shriver 

  

	 	•	 	Viswanathan Sasisekharan 

  

	 	•	 	Rahul Raman 

  

	 	•	 	Sasi Raguram 

  

	 	•	 	Ramasubramanian Kaundinya 

  

	 	•	 	Aarthi Chandrasekharan 

  

	 	•	 	Akila Jayaraman 

  

	 	•	 	Karthik Viswanathan. 

 Stock Transfer Agreement dated December 29, 2010 between Alan L. Crane and The
Crane Family Irrevocable Trust – 2002. 
 Common Stock Issuance Agreements dated April 20, 2011 between the Company and each of the following
parties: 
  

	 	•	 	Massachusetts Institute of Technology 

  

	 	•	 	Venkataramanan Soundararajan 

  
 - 5 - 

	 	•	 	Mahadevan Venkataraman 

  

	 	•	 	Aravind Srinivasan 

  

	 	•	 	Zachary Shriver 

  

	 	•	 	Viswanathan Sasisekharan 

  

	 	•	 	Rahul Raman 

  

	 	•	 	Sasi Raguram 

  

	 	•	 	Ramasubramanian Kaundinya 

  

	 	•	 	Aarthi Chandrasekharan 

  

	 	•	 	Akila Jayaraman 

  

	 	•	 	Karthik Viswanathan. 

 Please see the disclosures in Section 2.5(c) regarding the 2008 Patent License
Agreement. In addition, the Company has entered into stock option agreements with the holders of outstanding options in the table under Subsection 2.5(c) above. 

Management Rights Agreement dated February 28, 2011 between the Company and Lighthouse Capital Partners VI, L.P. 

Management Rights Agreement dated January 22, 2008 between the Company and Polaris Venture Partners V., L.P., Polaris Venture Partners
Entrepreneurs’ Fund V, L.P., Polaris Venture Partners Founders’ Fund V, L.P. and Polaris Venture Partners Special Founders’ Fund V, L.P. 

Management Rights Agreement dated May 13, 2008 between the Company and Flagship Ventures Fund 2007, L.P. 

Management Rights Agreement dated August 8, 2008 between the Company and Lux Ventures II, L.P. 

Subsection 2.5(g)(iii) 
 Stock option agreements between
the Company and the holders of outstanding options in the table under Subsection 2.5(c) above. 
 Warrants listed in Section 2.5(c). 

2008 Patent License Agreement. 
 Subsection 2.5(h) 

The following Stock Option Agreements between the Company and each of the individuals listed below have vesting schedules different than those listed in
Section 2.5(h) of the Agreement: 
  

	 	•	 	Brian Pereira dated October 16, 2013 

  

	 	•	 	Yadunanda Budigi dated October 16, 2013 

  

	 	•	 	Mark Kesic (a consultant to the Company) dated June 12, 2013 

  

	 	•	 	Mark Kesic (a consultant to the Company) dated October 16, 2013 

  
 - 6 - 

	 	•	 	William Cervino (a consultant to the Company) dated June 12, 2013 

  

	 	•	 	William Cervino (a consultant to the Company) dated October 16, 2013 

  

	 	•	 	George Siber (a consultant to the Company) dated October 16, 2013 

  

	 	•	 	Ralphael Dolin (a consultant to the Company) dated October 16, 2013 

  

	 	•	 	Ralphael Dolin (a consultant to the Company) dated March 18, 2009 

  

	 	•	 	Bob Gerety (a consultant to the Company) dated March 18, 2009 

  

	 	•	 	Steven Tannenbaum (a consultant to the Company) dated June 17, 2010 

  

	 	•	 	Steven Tannenbaum (a consultant to the Company) dated September 14, 2011 

  

	 	•	 	S. Raguram (a consultant to the Company) dated March 18, 2009 

  

	 	•	 	Mark Boshar (a consultant to the Company) dated March 18, 2009 

  

	 	•	 	Mark Boshar (a consultant to the Company) dated October 16, 2009 

  

	 	•	 	Mark Boshar (a consultant to the Company) dated February 1, 2011 

  

	 	•	 	Mark Boshar (a consultant to the Company) dated March 6, 2013 

 The following Employment Offer Letters
between the Company and each of the following executives provides for acceleration of vesting provisions in certain situations: 
  

	 	•	 	Brian Pereira, President and Chief Executive Officer of the Company, dated July 8, 2013 

  

	 	•	 	David Arkowitz, Chief Operating Officer and Chief Financial Officer of the Company, dated August 23, 2013 

  

	 	•	 	Greg Miller, Vice President of Business Development & Strategic Planning of the Company, dated August 23, 2013 

  

	 	•	 	Jose Trevejo, Vice President of Development of the Company, dated July 14, 2014 

 Terms of Employment
Agreement between the Company and Zach Shriver, Vice President of Research of the Company, dated December 7, 2012, provides for acceleration of vesting in certain situations. 

 

	Section 2.6	Subsidiaries. 

 Visterra Singapore International Pte. Ltd., a Singapore private company, is a
wholly-owned subsidiary of the Company. 
  

	Section 2.9	Intellectual Property. 

 The Company expects that the 2008 Patent License Agreement and patent
applications filed in the name of the Company will provide the Company with patents necessary to develop and commercialize its influenza therapeutics. The Company expects that the 2013 Patent License and patent applications filed in the name of the
Company will provide the Company with patents necessary to develop and commercialize its dengue fever therapeutics. The Company will likely require, and plans to pursue, additional patents and licenses to particular agents, drugs, drug combinations,
formulations and other technologies as it deems necessary. There can be no guaranty that the Company will obtain any such patents and licenses. 

  
 - 7 - 

 Pursuant to the Amended and Restated Letter Agreement, dated November 7, 2013, as amended September 4,
2014, between the Company and the Bill & Melinda Gates Foundation (the “Foundation”), the Company has granted the Foundation and its affiliates non-exclusive rights under certain of the Company’s patents and disease
information for the commercialization of certain antibody products in specified countries. 
 Consulting Agreement dated February 17, 2013 between the
Company and Ram Sasisekharan, which provides, among other things, for Dr. Sasisekharan to provide consulting services and assign certain inventions to the Company. Dr. Sasisekharan is an employee of MIT, and is accordingly bound by the
patent, consulting and other applicable policies of MIT. 
  

	Section 2.11	Contracts and Commitments. 

 Subsection 2.11(a) 

See Section 2.5(g)(ii). 
 Lease Agreement between the
Company and RB Kendall Fee, LLC, dated September 2, 2010. 
 2008 Patent License Agreement detailed in Section 2.5(f) and Section 2.9. 

2013 Patent License Agreement detailed in Section 2.9. 

Master Contract Services and License Agreement dated August 11, 2011 between the Company and ExcellGene SA. Effective as of August 1, 2013, the
Company terminated its non-exclusive license to use the Excellgene CHO cells and vectors. The Company maintained its exclusive license to the modified CHO cell line, which expresses the Company protein. 

Management Rights Agreement dated February 28, 2011 between the Company and Lighthouse Capital Partners VI, L.P. 

Management Rights Agreement dated January 22, 2008 between the Company and Polaris Venture Partners V., L.P., Polaris Venture Partners
Entrepreneurs’ Fund V, L.P., Polaris Venture Partners Founders’ Fund V, L.P. and Polaris Venture Partners Special Founders’ Fund V, L.P. 

Management Rights Agreement dated May 13, 2008 between the Company and Flagship Ventures Fund 2007, L.P. 

Management Rights Agreement dated August 8, 2008 between the Company and Lux Ventures II, L.P. 

Indemnification Agreement dated December 9, 2010 between the Company and Alan Crane. 

Amended and Restated Indemnification Agreement dated December 9, 2010 between the Company and Kevin Bitterman. 

  
 - 8 - 

 Indemnification Agreement dated December 9, 2010 between the Company and Edwin Kania. 

Indemnification Agreement dated December, 2010 between the Company and Ram Sasisekharan. 

Employment Agreement dated July 6, 2013 between the Company and Brian Pereira. 

Indemnification Agreement dated November 6, 2013 between the Company and Brian Pereira. 

2008 Stock Incentive Plan, as amended. 
 Common Stock Repurchase
Agreement, dated May 14, 2012 between the Company and Alan L. Crane. 
 Biopharmaceutical Development and Manufacturing Services Agreement, effective
June 21, 2012, between the Company and Laureate Biopharmaceutical Services, Inc. (n/k/a Gallus Biopharmaceuticals NJ, LLC) 
 Amended and Restated
Letter Agreement dated November 7, 2013 as amended September 4, 2014, between the Company and the Foundation. 
 Phase One Clinical Master
Services Agreement dated September 26, 2013 between the Company and PPD Development, LLC. 
 Letter Agreement dated May 15, 204 between and among
Merck Sharp & Dohme Corp., the Company’s stockholders set forth in the signature pages thereto and the Company. 
 Loan and Security Agreement
dated September 9, 2014 between the Company and Oxford Finance LLC and Square 1 Bank. 
 Equity Rights Side Letter dated September 9, 2014 between
the Company and Oxford Finance LLC. 
  

	Section 2.12	Related-Party Transactions. 

 Steven Brugger, the former President and Chief Executive Officer of the
Company, entered into a Severance Agreement with the Company on September 6, 2013. 
 Donna Ambrosino, the former Chief Medical Officer of the Company,
entered into a Severance Agreement with the Company on May 22, 2014. 
 Alan L. Crane, a founder and director of the Company, is a venture partner of
Polaris Venture Partners. Mr. Crane is a party to the following Material Contracts: 

  
 - 9 - 

	 	•	 	Restricted Stock Agreement dated December 20, 2007 between the Company and Alan L. Crane; 

  

	 	•	 	Letter Agreement dated December 28, 2007 between Alan L. Crane, the Company and The Crane Family Irrevocable Trust – 2002; 

 

	 	•	 	Common Stock Repurchase Agreement, dated May 14, 2012 between the Company and Alan L. Crane. 

 Ram
Sasisekharan, a founder and director of the Company, is an employee of MIT. MIT is a party to each of the Patent License Agreements. Dr. Sasisekharan is a party to the following Material Contracts: 

 

	 	•	 	Consulting Agreement dated February 17, 2013 between the Company and Ram Sasisekharan; 

  

	 	•	 	Restricted Stock Agreement dated December 20, 2007 between the Company and Ram Sasisekharan; 

  

	 	•	 	Letter Agreements dated December 28, 2007 between Ram Sasisekharan, the Company and each of the following parties: 

  

	 	•	 	the Sasisekharan Family 2006 Irrevocable Trust; 

  

	 	•	 	the Sasisekharan Parents 2006 Irrevocable Trust; 

  

	 	•	 	the Narayanasami Parents 2006 Irrevocable Trust; 

  

	 	•	 	S. Raguram; 

  

	 	•	 	Mahesh Narayanasami. 

 Edwin Kania, a director of the Company, is a managing partner and chairman at Flagship
Ventures. 
 Sasi Raguram, an inventor on patent applications included in the 2008 Patent License Agreement and a common stockholder of the Company, is the
brother of Ram Sasisekharan, a founder and director of the Company. 
 Karthik Viswanathan, an employee of the Company, is an inventor on certain patent
applications included in the 2008 Patent License Agreement and a common shareholder by virtue of the 2008 Patent License Agreement and the Common Stock Issuance Agreement between Mr. Viswanathan and the Company. 

Luke Robinson, an employee of the Company, is an inventor on certain patent applications included in the 2013 Patent License Agreement. 

Zachary Shriver, Vice President, Research of the Company, is an inventor on certain patent applications included in the 2008 Patent License Agreement and a
common shareholder by virtue 

  
 - 10 - 

 
of the 2008 Patent License Agreement and the Common Stock Issuance Agreement between Mr. Shriver and the Company. 

Management Rights Agreement dated January 22, 2008 between the Company and Polaris Venture Partners V., L.P., Polaris Venture Partners
Entrepreneurs’ Fund V, L.P., Polaris Venture Partners Founders’ Fund V, L.P. and Polaris Venture Partners Special Founders’ Fund V, L.P. 

Management Rights Agreement dated May 13, 2008 between the Company and Flagship Ventures Fund 2007, L.P. 

Management Rights Agreement dated August 8, 2008 between the Company and Lux Ventures II, L.P. 

Zachary Shriver, Vice President, Research of the Company, currently receives an annual salary of $280,000, a target bonus of 20% of his annual salary, and
currently holds options as shown in Subsection 2.5(f). 
 Brian Pereira, President and Chief Executive Officer of the Company, currently receives an annual
salary of $500,000, a target bonus of $500,000, and currently holds options as shown in Subsection 2.5(f). 
 David Arkowitz, Chief Operating Officer and
Chief Financial Officer of the Company, currently receives an annual salary of $305,000, a target bonus of 40% of his base salary, and currently holds options as shown in Subsection 2.5(f). Mr. Arkowitz received a $60,000 signing bonus upon
joining the Company in 2013. 
 Greg Miller, Vice President of Business Development & Strategic Planning of the Company, currently receives an
annual salary of $240,000, a target bonus of 25% of his base salary, and currently holds options as shown in Subsection 2.5(f). Mr. Miller received a $20,000 signing bonus upon joining the Company in 2013. 

Jose Trevejo, Vice President of Development of the Company, currently receives an annual salary of $275,000, a target bonus of 25% of his base salary, and is
expected to be granted options to purchase 425,000 shares of Common Stock by the Board of Directors at the next Board meeting held after the date hereof. Dr. Trevejo received a $130,000 signing bonus upon joining the Company in 2014. In
addition, Dr. Trevejo will receive a loan of up to $234,600 from the Company, the precise amount of which shall be equal to the amount he owes his prior employer as of August 11, 2014. The loan is to be evidenced by a promissory note in
favor of the Company and shall have a term ending December 31, 2017 and will bear interest at a rate equal to the minimum applicable federal rate. 
  

	Section 2.18	Employee Benefit Plans. 

 The Company offers the following benefits to employees: 

Medical: The Company offers employees Harvard Pilgrim Healthcare Value 15 PPO. 

  
 - 11 - 

 Dental: The Company offers employees Blue Cross Blue Shield Dental Blue. 

Life and ADD: The Company offers employees Simply Unum Life Insurance and Accidental Death and Dismemberment. 

Long-Term Disability Insurance: The Company offers Simply Unum. 

401(k): The Company offers employees a 401(k) plan through Fidelity Investments. 
  

	Section 2.21	Proprietary Information and Inventions Agreements. 

 None. 

  
 - 12 - 

 VISTERRA, INC. 

AMENDMENT NO. 1 TO 

AMENDED AND RESTATED SERIES B CONVERTIBLE PREFERRED STOCK 

PURCHASE AGREEMENT 
 This
Amendment dated as of December 4, 2015 (this “Amendment”) to the Amended and Restated Series B Convertible Preferred Stock Purchase Agreement dated as of September 12, 2014 by and among Visterra, Inc., a Delaware
corporation (the “Company”), and the Purchasers, Preferred Holders and Founder Holders named therein (the “Purchase Agreement”) is entered into by and among the Company and holders of more than 70% of the
Outstanding Registrable Securities (as defined in the Purchase Agreement). Capitalized terms used herein and not otherwise defined herein have the respective meanings ascribed to such terms in the Purchase Agreement. 

WHEREAS, Lighthouse Capital Partners VI, L.P. (“Lighthouse”) is the holder of warrants (the
“Warrants”) to purchase an aggregate of 87,500 shares of Seed Convertible Preferred Stock, $0.01 par value per share, of the Company; 

WHEREAS, the terms of the Warrants require that the Company grant to Lighthouse “piggyback” registration rights with respect
to the shares of Seed Preferred Stock issuable upon exercise of the Warrants (or, at all times when the Warrants are exercisable for Common Stock pursuant to their terms, the shares of Common Stock issuable upon exercise of the Warrants); and 

WHEREAS, pursuant to Section 11.10 of the Purchase Agreement, the terms of Section 8 of Purchase Agreement may be amended
with the written consent of the Company and the holders of more than seventy percent (70%) of the Outstanding Registrable Securities held by Preferred Holders (as defined in the Purchase Agreement) entitled to rights, or subject to obligations,
under such subsection; 
 NOW THEREFORE, for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged,
the Company and the holders of more than 70% of the Outstanding Registrable Securities held by Preferred Holders, do hereby agree as follows: 

1. Section 8.1(d). The definition of “Preferred Holder” in Section 8.1(d) of the Purchase Agreement is hereby
amended by deleting the “and” immediately prior to subsection (vi) thereof, deleting the proviso at the end thereof and adding the following text after Subsection (vi): 

“and (vii) with respect to the Applicable Sections only, Lighthouse Capital Partners VI, L.P. and any registered assigns to which it
transfers the rights granted under this Section 8 in accordance with Section 9(b) hereof (“Lighthouse”); provided, however, that none of the Square 1 Entities, the Oxford Entities or Lighthouse
shall be permitted to be an Initiating Holder (as hereinafter defined) under Section 8.2.” 

  
 1 

 2. Section 8.1(e). The definition of “Holders” in Section 8.1(e) of
the Purchase Agreement is hereby amended by deleting Subsection (i) thereof and replacing it with the following: 
 “(i) a
Preferred Holder, including the Square 1 Entities, the Oxford Entities and Lighthouse for purposes of the Applicable Sections,” 
 3.
Section 8.1(j). The definition of “Registrable Securities” is hereby amended by deleting the text following the comma at the end of Subsection (v) an replacing it with the following: 

“(vi) the Common Stock issued or issuable upon conversion of the shares of Preferred Stock issued or issuable upon exercise of the
Preferred Stock Purchase Warrants issued by the Company to Lighthouse (the “Lighthouse Warrants”) or, at all times when the Lighthouse Warrants are exercisable for Common Stock pursuant to their terms, the shares of Common Stock
issued and issuable upon exercise of the Lighthouse Warrants, and (vii) any Common Stock of the Company issued as (or issuable upon the conversion or exercise of any warrant, right, or other security which is issued as) a stock split, dividend
or other distribution with respect to, or in exchange for or in replacement of, the shares referenced in (i) through (vi) above, excluding in all cases, however, any Registrable Securities sold by a person in a transaction in which the
rights under this Section 8 are not properly assigned.” 
 4. Except as amended hereby, the Stock Purchase Agreement shall
remain in full force and effect. From and after the date of this Amendment, all references in the Agreement to “the Agreement” or “this Agreement” or similar terms shall be deemed to be references to the Agreement as amended
hereby. 
 5. This Amendment may be executed in one or more counterparts, each of which shall for all purposes be deemed to be an original
and all of which shall constitute the same document. 
 6. This Amendment shall be governed by, and construed and enforced in accordance
with, the laws of the State of Delaware, without regard to its principles of conflicts of laws. 
 [Remainder of page
intentionally left blank.] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed as an instrument
under seal as of the date first above written. 
  

			
	THE COMPANY
	
	VISTERRA, INC.
		
	By:	 	 /s/ Brian Pereira

	Name:	 	Brian Pereira
	Title:	 	President and Chief Executive Officer

 [Signature page to Amendment No. 1 to 

Amended and Restated Series B Preferred Stock Purchase Agreement] 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed as an instrument
under seal as of the date first above written. 
  

			
	PREFERRED HOLDERS:
	
	Merck Sharp & Dohme Corp.
		
	By:	 	 /s/ Jon Filderman

	Name:	 	Jon Filderman
	Title:	 	Secretary

  

							
	 POLARIS VENTURE PARTNERS

FOUNDERS’ FUND V, L.P.
	  	POLARIS VENTURE PARTNERS V, L.P.
		
	 By: POLARIS VENTURE MANAGEMENT
 CO.
V, L.L.C.
	  	 By: POLARIS VENTURE MANAGEMENT
 CO.
V, L.L.C.

	Its: General Partner	  	Its: General Partner
				
	By:	  	 /s/ William Bilodeau
	  	By:	  	 /s/ William Bilodeau

	Name:	  	William Bilodeau	  	Name:	  	William Bilodeau
	Title:	  	Attorney-in-Fact	  	Title:	  	Attorney-in-Fact
		
	 POLARIS VENTURE PARTNERS SPECIAL

FOUNDERS’ FUND V, L.P.
	  	 POLARIS VENTURE PARTNERS

ENTREPRENEURS’ FUND V, L.P.

		
	 By: POLARIS VENTURE MANAGEMENT
 CO.
V, L.L.C. its General Partner
	  	 By: POLARIS VENTURE MANAGEMENT
 CO.
V, L.L.C. its General Partner

				
	By:	  	 /s/ William Bilodeau
	  	By:	  	 /s/ William Bilodeau

	Name:	  	William Bilodeau	  	Name:	  	William Bilodeau
	Title:	  	Attorney-in-Fact	  	Title:	  	Attorney-in-Fact

 [Signature page to Amendment No. 1 to 

Amended and Restated Series B Convertible Preferred Stock Purchase Agreement] 

 PREFERRED HOLDERS (CONT.): 

FLAGSHIP VENTURES FUND 2007, L.P. 
 By: FLAGSHIP VENTURES 2007
GENERAL PARTNER L.L.C. 
 Its: General Partner 
  

					
	By:	  	 /s/ Edwin M. Kania,
Jr.                        
	  	
	Name:	  	Edwin M. Kania, Jr.	  	
	Title:	  	Manager	  	

 FLAGSHIP VENTURES FUND IV, L.P. 

By: FLAGSHIP VENTURES FUND IV GENERAL PARTNER L.L.C. 
 Its:
General Partner 
  

			
	By:	 	 /s/ Edwin M. Kania, Jr.

	Name:	 	Edwin M. Kania, Jr.
	Title:	 	Manager

 FLAGSHIP VENTURES FUND IV-Rx, L.P. 

By: FLAGSHIP VENTURES FUND IV GENERAL PARTNER L.L.C. 
 Its:
General Partner 
  

			
	By:	 	 /s/ Edwin M. Kania, Jr.

	Name:	 	Edwin M. Kania, Jr.
	Title:	 	Manager

 [Signature page to Amendment No. 1 to 

Amended and Restated Series B Convertible Preferred Stock Purchase Agreement] 

 PREFERRED HOLDERS (CONT.): 

V-SCIENCES INVESTMENT PTE LTD 
  

			
	 By:
	 	  

	Name:	 	
	Title:	 	

 VERTEX GLOBAL HEALTHCARE FUND I PTE. LTD. 
  

			
	By:	 	 /s/ Lincoln Chee

	Name:	 	Lincoln Chee
	Title:	 	Authorised Signatory

 [Signature page to Amendment No. 1 to 

Amended and Restated Series B Convertible Preferred Stock Purchase Agreement] 

 PREFERRED HOLDERS (CONT.): 

BILL & MELINDA GATES FOUNDATION 
  

			
	By:	 	 /s/ Andrew Farnum

	Name:	 	Andrew Farnum
	Title:	 	Deputy Director, Program-Related Investments

 [Signature page to Amendment No. 1 to 

Amended and Restated Series B Convertible Preferred Stock Purchase Agreement]EX-10.12

 Exhibit 10.12 

EXHIBIT 1, SHEET 1 
 Building
No.300, One Kendall Square 
 Cambridge, Massachusetts 

(the “Building”) 
  

					
	 Execution Date:
	  	September 2, 2010	  	
			
	 Tenant:
	  	 Visterra, Inc.
	  	
		  	           (name)	  	
			
		  	 a Delaware corporation
	  	
		  	                   (description of business organization)	  	
		
	 Mailing Address:
	  	Prior to the Term Commencement Date: 76 Rogers Street, Cambridge, MA 02142, Attn: President
		
		  	After the Term Commencement Date: Building 300, One Kendall Square, Cambridge, MA 02139, Attn: President
		
	 Landlord:
	  	RB Kendall Fee, LLC, a Delaware limited liability company
		
	 Mailing address:
	  	c/o The Beal Companies LLP, 177 Milk Street, Boston, Massachusetts 02109 Attn: Senior Vice President - Asset Management
		
	 Building:
	  	Building No. 300 in One Kendall Square in the City of Cambridge, Middlesex County, Commonwealth of Massachusetts

 Art. 2 Premises: An area on the third (3rd) floor of the Building,
substantially as shown on Lease Plan, Exhibit 2 
 Art. 3.1 Term Commencement Date: The date on which Landlord delivers the Premises to Tenant with
Tenant’s Improvements Substantially Completed (as hereinafter defined) 
 Art. 3.1 Specified Commencement Date: January 27, 2011 

Art. 3.2 Termination Date: The date that is forty-eight (48) full calendar months following the Term Commencement Date (subject to Tenant’s early
termination right as set forth in Section 3.2 herein) 
 Art. 5 Use of Premises: General office and laboratory use and for no other purpose, subject to
the terms and condition of the Lease. 
 Art. 6 Yearly/Monthly Rent * 
  

							
	 Time Period
	  	Yearly Rent	  	Monthly Rent	  	P.S.F.
	 Term Commencement Date through the end of the Twelfth (12th) full month
following the Term Commencement Date
	  	$301,000.00	  	$25,083.33	  	$43.00
	 Month 13 through Month 24
	  	$517,000.00	  	$43,083.33	  	$44.00
	 Month 25 through
	  	$528,750.00	  	$44.062.50	  	$45.00
	 Month 36
	  		  		  	

							
	 Month 37 through Month 48
	  	$540,500.00	  	$45,041.67	  	$46.00

  

	*	Yearly Rent, Operating Expense Share and Tax Share during the first twelve (12) months of the term shall be calculated based on a total rentable area of 7,000 rsf. Commencing on the thirteenth (13th) month of the term, Yearly Rent, Operating Expense Share and Tax Share shall be calculated based upon the total rentable area of the Premises-that being 11,750 rsf. 

Art. 7 Total Rentable Area: 11,750 square feet 

  Total Rentable Area of Building No.300: 64.610 square feet 

  Total Rentable Area of Complex: 639,586 square feet 

Art. 8 Electric current will be furnished by Landlord to Tenant 

Art. 9 Operating and Taxes: 

  Tenant’s Proportionate Common Share: 1.84% 

  Tenant’s Proportionate Building Share: 18.19% 

Art. 29.3 Broker: Colliers Meredith & Grew and FHO Partners 

Art. 29.5 Arbitration: Massachusetts; Superior Court 
 Art.
29.13 Security Deposit: $117,953.12 in the form of a Letter of Credit in accordance with Article 29.13 
 Art. 29.14 Parking Spaces: Eleven (11) spaces

 Art. 29.15 Option to Extend Term: One (1) two (2) year option 

									
	 1
	 	 REFERENCE DATA
	  	 	6	  
			
	 2
	 	 DESCRIPTION OF DEMISED PREMISES
	  	 	6	  
				
		 	 2.1
	  	 Demised Premises
	  	 	6	  
		 	 2.2
	  	 Appurtenant Rights
	  	 	6	  
		 	 2.3
	  	 Exclusions and Reservations
	  	 	6	  
			
	 3
	 	 TERM OF LEASE
	  	 	6	  
				
		 	 3.1
	  	 Definitions
	  	 	6	  
		 	 3.2
	  	 Habendum
	  	 	7	  
		 	 3.3
	  	 Declaration Fixing Term Commencement Date
	  	 	8	  
			
	 4
	 	 READINESS FOR OCCUPANCY
	  	 	8	  
				
		 	 4.1
	  	 Tenant’s Improvements
	  	 	8	  
		 	 4.2
	  	 Entry by Tenant Prior to Term Commencement Date
	  	 	11	  
		 	 4.3
	  	 Condition of Premises
	  	 	11	  
		 	 4.4
	  	 Included Furniture
	  	 	11	  
			
	 5
	 	 USE OF PREMISES
	  	 	11	  
				
		 	 5.1
	  	 Permitted Use
	  	 	11	  
		 	 5.2
	  	 Prohibited Uses
	  	 	12	  
		 	 5.3
	  	 Licenses and Permits
	  	 	12	  
			
	 6
	 	 RENT
	  	 	12	  
			
	 7
	 	 RENTABLE AREA
	  	 	13	  
			
	 8
	 	 SERVICES FURNISHED BY LANDLORD
	  	 	13	  
				
		 	 8.1
	  	 Electric Current
	  	 	13	  
		 	 8.2
	  	 Water
	  	 	14	  
		 	 8.3
	  	 Elevators, Heat and Cleaning
	  	 	15	  
		 	 8.4
	  	 Air Conditioning
	  	 	15	  
		 	 8.5
	  	 Additional Heat and Air Conditioning Services
	  	 	15	  
		 	 8.6
	  	 Additional Air Conditioning Equipment
	  	 	15	  
		 	 8.7
	  	 Repairs
	  	 	16	  
		 	 8.8
	  	 Interruption or Curtailment of Services
	  	 	16	  
		 	 8.9
	  	 Energy Conservation
	  	 	17	  
			
	 9
	 	 ESCALATION
	  	 	17	  
				
		 	 9.1
	  	 Definitions
	  	 	17	  
		 	 9.2
	  	 Tax Share
	  	 	22	  
		 	 9.3
	  	 Operating Expense Share
	  	 	22	  
		 	 9.4
	  	 Part Years
	  	 	22	  
		 	 9.5
	  	 Effect of Taking
	  	 	22	  
		 	 9.6
	  	 Survival
	  	 	23	  
			
	 10
	 	 CHANGES OR ALTERATIONS BY LANDLORD
	  	 	23	  
			
	 11
	 	 FIXTURES, EQUIPMENT AND IMPROVEMENTS-REMOVAL BY TENANT
	  	 	23	  
			
	 12
	 	 ALTERATIONS AND IMPROVEMENTS BY TENANT
	  	 	24	  

									
	 13
	 	 TENANT’S CONTRACTORS-MECHANICS’ AND OTHER LIENS-STANDARD OF TENANT’S PERFORMANCE-COMPLIANCE WITH
LAWS
	  	 	25	  
			
	 14
	 	 REPAIRS BY TENANT-FLOOR LOAD
	  	 	25	  
				
		 	 14.1
	  	 Repairs by Tenant
	  	 	25	  
		 	 14.2
	  	 Floor Load-Heavy Machinery
	  	 	26	  
			
	 15
	 	 INSURANCE, INDEMNIFICATION, EXONERATION AND EXCULPATION
	  	 	26	  
				
		 	 15.1
	  	 General Liability Insurance
	  	 	26	  
		 	 15.2
	  	 Certificates of Insurance
	  	 	27	  
		 	 15.3
	  	 General
	  	 	27	  
		 	 15.4
	  	 Property of Tenant
	  	 	28	  
		 	 15.5
	  	 Bursting of Pipes, etc
	  	 	28	  
		 	 15.6
	  	 Repairs and Alterations-No Diminution of Rental Value
	  	 	29	  
			
	 16
	 	 ASSIGNMENT, MORTGAGING AND SUBLETTING
	  	 	29	  
				
		 	 16.1
	  	 Generally
	  	 	29	  
		 	 16.2
	  	 Reimbursement, Recapture and Excess Rent
	  	 	30	  
		 	 16.3
	  	 Certain transfers
	  	 	32	  
			
	 17
	 	 MISCELLANEOUS COVENANTS
	  	 	33	  
				
		 	 17.1
	  	 Rules and Regulations
	  	 	33	  
		 	 17.2
	  	 Access to Premises-Shoring
	  	 	33	  
		 	 17.3
	  	 Accidents to Sanitary and Other Systems
	  	 	34	  
		 	 17.4
	  	 Signs, Blinds and Drapes
	  	 	34	  
		 	 17.5
	  	 Estoppel Certificate and Financial Statements
	  	 	34	  
		 	 17.6
	  	 Prohibited Materials and Property
	  	 	35	  
		 	 17.7
	  	 Requirements of Law-Fines and Penalties
	  	 	35	  
		 	 17.8
	  	 Tenant’s Acts—Effect on Insurance
	  	 	35	  
		 	 17.9
	  	 Miscellaneous
	  	 	36	  
			
	 18
	 	 DAMAGE BY FIRE, ETC
	  	 	36	  
			
	 19
	 	 WAIVER OF SUBROGATION
	  	 	37	  
			
	 20
	 	 CONDEMNATION-EMINENT DOMAIN
	  	 	37	  
			
	 21
	 	 DEFAULT
	  	 	38	  
				
		 	 21.1
	  	 Conditions of Limitation Re-Entry-Termination
	  	 	38	  
		 	 21.2
	  	 Intentionally Omitted
	  	 	39	  
		 	 21.3
	  	 Damages-Termination
	  	 	39	  
		 	 21.4
	  	 Fees and Expenses
	  	 	40	  
		 	 21.5
	  	 Waiver of Redemption
	  	 	40	  
		 	 21.6
	  	 Landlord’s Remedies Not Exclusive
	  	 	40	  
		 	 21.7
	  	 Grace Period
	  	 	40	  
			
	 22
	 	 END OF TERM-ABANDONED PROPERTY
	  	 	41	  
			
	 23
	 	 SUBORDINATION
	  	 	42	  
			
	 24
	 	 QUIET ENJOYMENT
	  	 	43	  
			
	 25
	 	 ENTIRE AGREEMENT-WAIVER-SURRENDER
	  	 	44	  
				
		 	 25.1
	  	 Entire Agreement
	  	 	44	  

									
		 	 25.2
	  	 Waiver by Landlord
	  	 	44	  
		 	 25.3
	  	 Surrender
	  	 	44	  
			
	 26
	 	 INABILITY TO PERFORM-EXCULPATORY CLAUSE
	  	 	44	  
			
	 27
	 	 BILLS AND NOTICES
	  	 	45	  
			
	 28
	 	 PARTIES BOUND-SEIZING OF TITLE
	  	 	46	  
			
	 29
	 	 MISCELLANEOUS
	  	 	46	  
				
		 	 29.1
	  	 Separability
	  	 	46	  
		 	 29.2
	  	 Captions, etc
	  	 	46	  
		 	 29.3
	  	 Broker
	  	 	46	  
		 	 29.4
	  	 Modifications
	  	 	46	  
		 	 29.5
	  	 Arbitration
	  	 	46	  
		 	 29.6
	  	 Governing Law
	  	 	47	  
		 	 29.7
	  	 Assignment of Rents
	  	 	47	  
		 	 29.8
	  	 Representation of Authority
	  	 	47	  
		 	 29.9
	  	 Expenses Incurred by Landlord Upon Tenant Requests
	  	 	47	  
		 	 29.10
	  	 Survival
	  	 	47	  
		 	 29.11
	  	 Hazardous Materials
	  	 	48	  
		 	 29.12
	  	 Patriot Act
	  	 	49	  
		 	 29.13
	  	 Security Deposit/Letter of Credit
	  	 	50	  
		 	 29.14
	  	 Parking
	  	 	51	  
		 	 29.15
	  	 Tenant’s Option to Extend the Term of the Lease
	  	 	52	  
		 	 29.16
	  	 Definition of Fair Market Rental Value
	  	 	52	  
		 	 29.17
	  	 Roof-Top License
	  	 	53	  

 Exhibit 2 Lease Plan 
 Exhibit 2A
Work Scope 
 Exhibit 2B Plan Showing Location of ANS 
 Exhibit
2C Included Furniture 
 Exhibit 3 Plan of Complex 
 Exhibit 4
Term Commencement Date Agreement 
 Exhibit 5 Form of Letter of Credit 

Exhibit 6 Tenant’s Personal Property 

 THIS INDENTURE OF LEASE made and entered into on the Execution Date as stated in Exhibit 1 and
between the Landlord and the Tenant named in Exhibit 1. 
 Landlord does hereby demise and lease to Tenant, and Tenant does hereby hire and
take from Landlord, the premises hereinafter mentioned and described (hereinafter referred to as “Premises”), upon and subject to the covenants, agreements, terms, provisions and conditions of this Lease for the term hereinafter stated:

  

	1.	REFERENCE DATA 

 Each reference in this Lease to any of the terms and titles contained in
any Exhibit attached to this Lease shall be deemed and construed to incorporate the data stated under that term or title in such Exhibit. 
  

	2.	DESCRIPTION OF DEMISED PREMISES 

 2.1 Demised Premises. The Premises are that
portion of the Building as described in Exhibit 1 (as the same may from time to time be constituted after changes therein, additions thereto and eliminations therefrom pursuant to rights of Landlord hereinafter reserved) and is hereinafter referred
to as the “Building”, which Premises are substantially as shown hatched or outlined on the Lease Plan (Exhibit 2) hereto attached and incorporated by reference as a part hereof. 

2.2 Appurtenant Rights. Tenant shall have, as appurtenant to the Premises, rights to use twenty-four (24) hours per day, seven (7
)days per week, three hundred and sixty-five (365) days per year, except in the case of force majeure, emergencies or closures due to casualty or condemnation or repairs, maintenance or alterations, within the Complex and except as otherwise
provided herein, in common, with others entitled thereto, subject to reasonable rules and regulations from time to time made by Landlord of which Tenant is given notice and at no additional charge to Tenant (provided, however, that the cost to
operate and maintain to areas described herein may be included as Operating Costs (as hereinafter defined); (a) the Common Areas (as defined in Section 3.1(d)), including, without limitation, the common lobbies, hallways, stairways and
elevators of the Building, serving the Premises in common with others, (b) common walkways necessary for access to the Building, (c) if the Premises include less than the entire rentable area of any floor, the common toilets and other
common facilities of such floor and (d), during business hours (as hereinafter defined), common loading dock facilities; and no other appurtenant rights or easements, except as otherwise expressly provided herein. Notwithstanding the foregoing, even
in the event of Landlord repairs, Tenant shall continue to have access to the Premises. While Tenant occupies the Premises for the uses permitted pursuant to Section 5, Tenant shall also have the right to use in support of its operations in the
Premises the acid neutralization system located in the basement of the Building as shown on Exhibit 2B attached hereto, which acid neutralization system exclusively serves the Premises. 

2.3 Exclusions and Reservations. All the perimeter walls of the Premises except the inner surfaces thereof, any balconies (except to
the extent same are shown as part of the Premises on the Lease Plan (Exhibit 2)), terraces or roofs adjacent to the Premises, and any space in or adjacent to the Premises used for shafts, stacks, pipes, conduits, wires and appurtenant fixtures, fan
rooms, ducts, electric or other utilities, sinks or other Building facilities, and the use thereof, as well as the right of access through the Premises, subject to Section 17.2, for the purposes of operation, maintenance, decoration and repair,
are expressly excluded, from the Premises and reserved to Landlord. 
  

	3.	TERM OF LEASE 

 3.1 Definitions. As used in this Lease the words and terms which
follow mean and include the following: 

  
 6 

 (a) “Specified Commencement Date” - The date (as stated in Exhibit 1) on which it is
estimated that the Premises will be ready for Tenant’s occupancy for its use as stated in Exhibit 1. 
 (b) “Term Commencement
Date” - the “Term Commencement Date” is the date on which the Premises are delivered to Tenant with the Tenant’s Improvements Substantially Completed and ready for Tenant’s occupancy (as defined in Article 4.2) for the
conduct of its business for the use as set forth in Exhibit 1. If the Premises are not ready for such occupancy but if, pursuant to permission therefor duly given by Landlord, Tenant takes possession of the whole or any part of the Premises for use
as set forth in Exhibit 1, “Term Commencement Date” shall be the date on which Tenant takes such possession. 
 (c)
“Complex” shall be defined as all of the Building, the other buildings, and the Common Areas serving such buildings, all, located on the land (“Land”) shown outlined on Exhibit 3. 

(d) “Common Areas” shall be defined as the common walkways, accessways, and parking facilities located on the Land and common
facilities in the Complex, as the same may be changed, from time to time, including without limitation, alleys, sidewalks, lobbies, hallways, toilets, stairways, fan, rooms, utility closets, shaftways, street entrances, elevators, wires, conduits,
meters, pipes, ducts, vaults, and any other equipment, machinery, apparatus, and fixtures wherever located on the Land, in the Complex, in the buildings in the Complex or in the Premises that either (a) serve the Premises as well as other parts
of the Land or Complex, or (b) serve other parts of the Land or Complex but not the Premises. 
 3.2 Habendum. TO HAVE AND TO
HOLD the Premises for a term of years commencing on the Term Commencement Date and ending at 11:59 p.m. on the last day of the forty-eighth (48th) complete month following the Term
Commencement Date (as same may be extended in accordance with Section 29.15 below) or on such earlier date upon which said term may expire or be terminated pursuant to any of the conditions of limitation or other provisions of this Lease or
pursuant to law (which date for the termination of the terms hereof will hereafter be called “Termination Date”). Notwithstanding the foregoing, if the Termination Date as stated in Exhibit 1 shall fall on other than the last day of a
calendar month, said Termination Date shall, at the option of Landlord (to be exercised by Landlord when it requests Tenant’s signature to the Term Commencement Date Agreement in the form attached as Exhibit 4), be deemed to be the last day of
the calendar month in which said Termination Date occurs. 
 Notwithstanding the foregoing, at the expiration of the third (3rd) year following the Term Commencement Date, and provided Tenant is not in default under the terms of this Lease, Tenant shall have the right to terminate this Lease upon written notice to
Landlord given no later than nine (9) months prior to the expiration of the third (3rd) year following the Term Commencement Date and after payment to Landlord of the sum of
(i) brokerage fees calculated as 28.6% of the amount paid by Landlord to Colliers Meredith & Grew and FHO Partners, as shown on copies of the applicable paid invoices therefor, (ii) 28.6% of legal fees for the drafting and
negotiation of this Lease (which at 100% shall not exceed $20,000 as shown on a copy of a paid invoice therefor); (iii) 28.6% of the architect’s fee for the design of the Tenant’s Improvements charged by Randy Lewis (which at 100%
shall not exceed $42,909 as shown on a copy of a paid invoice therefor), and (iv) 28.6% of the construction costs of the Tenant’s improvements as such costs are detailed in the Budget and Description of Turnkey and Costs by The Richmond
Group dated July 13, 2010 (which at 100% are estimated to be $1,009,088 as shown on a copy of the paid invoice therefor) plus the cost of demolition completed by Landlord in connection with Tenant’s improvements as shown on a copy of the
paid invoice therefor (which at 100% shall not exceed $55,000) (collectively, the “Transaction Costs”). The actual Transaction Costs and the paid invoices therefor shall be provided by Landlord to Tenant within 90 days after the Term
Commencement Date. After receipt of Tenant’s termination notice Landlord shall provide Tenant with written notice of the Transaction Costs and Tenant shall pay its portion of the Transaction Costs within thirty (30) days of receipt of
Landlord’s notice, in such case the Lease shall be deemed terminated as of the expiration of the third (3rd) year following the Term Commencement Date. In the event Tenant terminates
this Lease to relocate to larger space within the Complex, then Tenant shall not be required to pay the Transaction Costs. This right shall be personal to 

  
 7 

 
Visterra, Inc. and shall be assignable only in accordance with an assignment of this Lease as permitted under Section 16.3 of this Lease. 

3.3 Declaration Fixing Term Commencement Date. Landlord and Tenant hereby agree to execute a Term Commencement Date Agreement
substantially in the form attached hereto as Exhibit 4, or as otherwise reasonably requested by Landlord confirming the actual Term Commencement Date and Termination Date, once same are determined. As soon as may be after the execution date hereof,
each of the parties hereto agrees, upon demand of the other party to join in the execution, in recordable form, of a statutory notice, memorandum, etc. of lease. If this Lease is terminated before the term expires, then upon Landlord’s request
the parties shall execute, deliver and record an instrument acknowledging such fact and the date of termination of this Lease, and Tenant hereby appoints Landlord its attorney- in-fact in its name and behalf to execute such instrument if Tenant
shall fail to execute and deliver such instrument after Landlord’s request therefor within ten (10) days. In no event shall this Lease be recorded or filed by Tenant with the Middlesex South Registry of Deeds or Middlesex South Registry
District of the Land Court. 
  

	4.	READINESS FOR OCCUPANCY 

 4.1 Tenant’s Improvements. 

(a) Landlord and Tenant have mutually agreed to the (i) Architectural Drawing by Randy Lewis Architect dated July 13, 2010 (the
“Architectural Drawing”), (ii) Construction Schedule by The Richmond Group dated July 13, 2010, (iii) Budget and Description of Turnkey and Costs by The Richmond Group dated July 13, 2010, and (iv) Equipment and
Utility Matrix by The Richmond Group and Tenant dated July 13, 2010 (items (i), (ii), (iii) and (iv) are collectively referred to as the “Work Scope”) for the layout and plans and specifications of Tenant’s leasehold
improvements to the Premises (the “Tenant’s improvements”). Landlord shall be responsible for delivering, at its sole cost and expense (subject to Section 4.1(b) below) the Premises with the Tenant’s Improvements
Substantially Completed (as defined below). Tenant’s improvements shall not include, without limitation, Tenant’s furniture, trade fixtures, equipment (except as otherwise set forth in the Work Scope), personal property, data and
communications equipment and cabling, and shall be limited to construction as generally laid out and specified in the Work Scope. The Tenant’s Improvements shall include the electrical and HVAC capacities and distribution as set forth in or to
accommodate the above-listed Work Scope. Except as otherwise may be expressly provided on the Plans (as hereinafter defined), Tenant acknowledges that Tenant’s Improvements will be designed and constructed to the general quality of the design
and construction of the Building and in accordance with Landlord’s building standards (including but not limited to construction materials, design and finishes) for the Building. The Work Scope is attached hereto as Exhibit 2A. 

(b) Based upon the Work Scope, the Landlord shall cause final plans and specifications, sufficient to permit the construction of Tenant’s
Improvements, to be prepared (the “Plans”), which Plans shall be submitted to Tenant for approval, which approval shall not be unreasonably withheld or delayed and shall be deemed given if not disapproved of in writing (with a detailed
list of the deficiencies in the Plans), within five (5) days of submittal. Tenant shall not be deemed to have unreasonably withheld its consent if the Plans are inconsistent with the Work Scope. Tenant understands and agrees that changes to the
Work Scope or the Plans that may be needed or desired by Tenant, and or the specification by Tenant of any components or finishes that are not Building standard or as depicted on the Work Scope or Plans, will be approved by Landlord and incorporated
into the Work Scope or Plans only if (1) such changes are not Material Changes (as defined below) or (2) Tenant agrees to pay (as provided below) any net increase in the cost of the Tenant’s Improvements resulting from such changes
and be responsible for any resulting delay in Substantial Completion. The term “Material Changes” as used herein are (i) changes that, individually or in the aggregate, modify the scope, cost or character of the Tenant’s
improvements or any material component thereof from that set forth in the Work Scope or Plans, and (ii) changes that will, individually or in the aggregate, in Landlord’s reasonable opinion, result in a likelihood of material delay in the
Substantial Completion of Tenant’s Improvements Tenant agrees that any additional cost or expense resulting from any Material Changes approved by Landlord, as well as from any changes requested by Tenant to the Tenant’s Improvements after
the date hereof (including design and construction costs, including, but not limited to, 

  
 8 

 
materials, labor and general conditions costs) shall be the responsibility of Tenant and shall be paid in full, or reimbursed, as the case may be, by Tenant to Landlord within thirty
(30) business days of billing therefor by Landlord; and Tenant agrees that if any such changes do result in delay in Substantial Completion, same shall be deemed a Tenant Delay (as defined below), 

(c) Landlord shall proceed to construct Tenant’s Improvements at Landlord’s sole cost and expense (except as otherwise set forth
herein) in substantial conformance with the Plans and in a good and workmanlike manner, including, without limitation, that all materials and equipment furnished as part of the Tenant’s Improvements shall be of good quality. All
manufacturer’s or suppliers warranties on equipment installed as part of the Tenant’s Improvements shall be assigned to Tenant upon the Substantial Completion Date (except for the warranties on equipment subject to the one-year warranty
set forth in Section 4.1(f) for systems that would not normally be operating at the time of Substantial Completion, which warranties shall be assigned to Tenant one year after the Substantial Completion Date, to the extent assignable, it being
acknowledged and agreed that Tenant shall be responsible for maintaining and repairing such equipment. If Tenant elects to pay for extended warranties thereon Landlord will cooperate with Tenant in such efforts by Tenant. To the extent there is any
term left on said warranties upon the expiration or earlier termination of this Lease, such warranties shall be assigned back to Landlord to the extent assignable. Landlord reserves the right to make changes and substitutions to the Plans in
connection with the construction of Tenant’s Improvements, provided same do not materially adversely modify the Plans or substitute materials of equipment of lesser quality than as specified in the Plans, and Tenant agrees to not unreasonably
withhold or delay its consent to any changes that do not materially adversely modify the Plans or substitute materials or equipment of lesser quality than as specified in the Plans. Tenant’s Improvements shall be constructed and completed by
The Richmond Group whom Landlord shall engage to be Landlord’s contractor, in compliance with all applicable statutes and regulations. 

(d) Landlord agrees to use reasonable speed and diligence to Substantially Complete Tenant’s Improvements by the Specified Commencement
Date, provided, however, the failure to do so shall in no way affect the validity of this Lease except as provided in Section 4.1(g) or the obligations of Tenant hereunder nor shall the same be construed in any way to extend the term of this
Lease and Tenant shall not have any claim against Landlord, and Landlord shall have no liability to Tenant, by reason thereof. 
 (e)
Tenant’s Improvements shall be deemed “Substantially Complete” on the date (the “Substantial Completion Date”) all approvals necessary to legally occupy the Premises have been received from the City of Cambridge and Tenant
receives Landlord’s architect’s certificate that the Premises are substantially completed in accordance with the Plans (subject only to the completion of Punchlist Work (defined below)). Landlord agrees to deliver copies of all such
approvals to Tenant upon the Tenant’s written request. Any Punchlist Work not fully completed (of which Tenant shall give Landlord notice as provided below) on the Term Commencement Date shall thereafter be so completed with reasonable
diligence by Landlord, but in no event shall such Punchlist Work be fully completed later than forty-five (45) days after the date the Punchlist is created. Notwithstanding the foregoing, if any delay in the Substantial Completion of the
Tenant’s Improvements by Landlord is due to Tenant Delays, then the Substantial Completion Date shall be deemed to be the date Tenant’s Improvements would have been Substantially Complete, if not for such Tenant Delays, as reasonably
determined by Landlord’s architect. “Tenant Delays” shall mean delays caused by: (i) requirements of any changes to Work Scope or Plans requested by Tenant, as provided in Section 4.1(b), which contain long lead-time or
non-standard items requested by Tenant; (ii) any material change in the Work Scope or Plans requested by Tenant; (iii) any request by Tenant for a delay in the commencement or completion of Tenant’s Improvements for any reason; or
(iv) any other act or omission of Tenant or its employees, agents or contractors which actually delays the Landlord from timely completing the Tenant’s Improvements. For purposes hereof, “Punchlist Work” is defined as minor or
insubstantial details or defects of construction, decoration or mechanical adjustments that do not materially affect Tenant’s use of the Premises for the Permitted Use. If as a result of Tenant Delays the Premises are deemed ready for
Tenant’s occupancy, pursuant to the foregoing (and the Term shall have commenced by reason thereof), but the Premises are not in fact actually ready for Tenant’s occupancy, Tenant shall not (except with Landlord’s consent not to be
unreasonably withheld, conditioned 

  
 9 

 
or delayed) be entitled to take possession of the Premises for use as set forth in Exhibit 1 until the Premises are in fact actually ready for such occupancy. 

(f) Within seven (7) business days after the Term Commencement Date, Landlord and Tenant shall confer and create a specific list of any
Punchlist Work remaining items of work with respect to Tenant’s Improvements (a “Punchlist”). Except with respect to the items contained in the Punchlist and as otherwise expressly provided herein, Tenant shall be deemed satisfied
with Tenant’s Improvements, Landlord shall be deemed to have completed all of its obligations under this Section 4.1 and Tenant shall have no claim that Landlord has failed to perform in full its obligations hereunder. Tenant’s taking
possession and acceptance of the Premises shall not constitute a waiver of: (i) any manufacturer warranty with regard to equipment installed as part of Tenant’s Improvements; (ii) any non-compliance of the Tenant’s Improvements
with applicable laws and regulations, or (iii) any claim that the Tenant’s Improvements were not completed substantially in accordance with the Plans (subject to changes thereto as permitted hereunder) (collectively, a “Construction
Defect”). Except for latent defects (which term expressly excludes any design defects in the layout and configuration of the Tenant’s improvements), Tenant shall have ninety (90) days after Substantial Completion (or one (1) year
after Substantial Completion in the case of latent defects and systems that would not normally be operating at the time of Substantial Completion such as air conditioning systems) within which to notify Landlord of any such Construction Defect
discovered by Tenant, and Landlord shall use reasonable efforts to remedy or cause the responsible contractor to remedy any such Construction Defect in a timely manner. 

(g) This Lease is subject to the Landlord obtaining, at its sole cost and expense, all permits, licenses and approvals necessary to allow
Landlord to construct Tenant’s Improvements; and if despite Landlord’s good faith efforts, Landlord shall be unable to obtain such permits, license or approvals, and is therefore unable to commence or complete Tenant’s Improvements,
then this Lease may be terminated by Landlord or Tenant by written notice to the other party. In addition, if the Tenant’s Improvements are not Substantially Complete within sixty (60) days of the Specified Commencement Date for any reason
other than Tenant Delays, this Lease may be terminated by Tenant by written notice to Landlord. Notwithstanding the foregoing, in the event Landlord is able to provide Tenant with temporary space for its business operations prior to the expiration
aforementioned sixty (60) day period then Tenant shall not have a termination right unless the Tenant’s Improvements are not Substantially Complete within ninety (90) days of the Specified Commencement Date for any reason other than
Tenant Delays. Landlord shall pay Tenant’s moving costs to relocate to such temporary space. In the event of a termination under this Section 4.1(g): (a) the Security Deposit and any rent paid in advance shall be promptly returned to
Tenant, and (b) neither Landlord nor Tenant shall have any further rights, duties or obligations under this Lease, except with respect to provisions which expressly survive termination of this Lease. 

(h) Tenant shall have the exclusive right, during the term of this Lease, to use the Kohler 50KW generator located on the roof of the Building
which serves only the Premises (the “Generator”), the acid neutralization system located in the basement of the Building as shown on Exhibit 2B attached hereto (the “ANS”) and the RODI System located in the Premises (the
“RODI”). Landlord shall provide that the Generator, ANS and RODI are in good working order operating condition and repair on the Term Commencement Date. After the Term Commencement Date Tenant shall: (i) maintain, at its sole cost,
the Generator, ANS and RODI in the same condition in which it is delivered to Tenant, reasonable wear and tear and damage caused by fire or other casualty excepted and deliver the Generator, ANS and RODE in said condition to Landlord, at the end of
the term; (ii) not remove from the Premises or alter the Generator, ANS or RODI and (iii) maintain in effect throughout the term of this Lease a maintenance agreement with duly licensed contractors to provide routine maintenance to the
Generator, ANS and RODI (Tenant to provide Landlord with copies of such agreements), Tenant shall perform all necessary maintenance and repair (but not replacement) of the Generator, ANS and RODI to keep same in good working order and repair at all
times. Landlord agrees to replace the Generator, ANS or RODI if such equipment is beyond its useful life as reasonably determined by Landlord’s engineers and if the cost to repair said equipment will exceed the cost to replace same. 

  
 10 

 (i) Landlord agrees to provide Tenant with copies of any existing decommissioning reports for the
Premises prepared by the prior tenant of the Premises. 
 (j) Tenant or Tenant’s agents shall have the right to inspect the Premises,
the Building and all base building systems including HVAC upgrades prior to the Term Commencement Date with prior notice to Landlord and in the presence of Landlord or its agents. 

(k) Landlord shall deliver the Premises in compliance with all applicable provisions of the Americans with Disabilities Act. 

4.2 Entry by Tenant Prior to Term Commencement Date. With Landlord’s prior written consent, which shall not be unreasonably
withheld, Tenant shall have the right to enter the Premises prior to the Term Commencement Date, during normal business hours and without payment of rent, to perform such work or decoration as is to be performed by, or under the direction or control
of, Tenant and as is otherwise to compliance with the terms of this Lease; provided such entry does not interfere with Landlord’s completion of Tenant’s Improvements. Such right of entry shall be subject to all provisions of this Lease
(except the obligation to pay Yearly Rent and additional rent), and any entry thereunder shall be at the risk of Tenant. 
 4.3 Condition
of Premises. Landlord shall deliver new base building “lab ready” infrastructure capable of supporting Tenant’s improvements. This infrastructure to include new HVAC components capable of providing 1.5 CFM per square foot of 100%
outside air to the laboratory portions only of the Premises. The HVAC system serving the office space shall be sized and distributed to accommodate the Tenant’s Improvements and to meet all applicable building codes. Landlord shall deliver all
base building systems serving the Premises, including mechanical, electrical and plumbing systems, as well as all structural and common area components of the Building including the roof, elevators, windows, parking garage, parking deck, loading
docks, building lobby, Common Areas and life safety infrastructure of the Building in good operating condition. Landlord shall maintain these aspects of the Building and Complex in a first class manner commensurate with similar mixed use facilities
in Cambridge, Massachusetts. 
 4.4 Included Furniture. Tenant shall have the right, during the term of this Lease, to use the office
furniture that is listed on Exhibit 2C attached hereto, which will remain in the Premises on the Term Commencement Date (the “Included Furniture”). No later than September 15, 2010, Tenant will provide Landlord with written notice of
any of the Included Furniture Tenant decides it does not want to remain in the Premises. After receipt of such written notice Exhibit 2C of this Lease will be revised to reflect the correct list of furniture that will remain in the Premises. Tenant
shall accept the Included Furniture in the condition in which the Included Furniture is in as of the Term Commencement Date, without any representation or warranty by Landlord to Tenant as to the condition of the Included Furniture. Tenant shall:
(i) maintain the Included Furniture in the same condition in which it is delivered to Tenant, reasonable wear and tear and damage caused by fire or other casualty excepted and deliver the included Furniture in said condition to Landlord at the
end of the term; (ii) not remove from the Premises or alter the Included Furniture and (iii) obtain and maintain, throughout the term of this Lease, property insurance, with a company reasonably acceptable to Landlord, for 100% of the book
value of the Included Furniture, naming Landlord as an additional insured and shall provide Landlord with evidence of such coverage prior to the Term Commencement Date 
  

	5.	USE OF PREMISES 

 5.1 Permitted Use. Tenant shall use the Premises only for the
purposes as stated in Exhibit 1 and for no other purposes. Service and utility areas (whether or not a part of the Premises) shall be used only for the particular purpose for which they were designed. Without limiting the generality of the
foregoing, Tenant agrees that it shall not use the Premises or any part thereof, or permit the Premises or any 

  
 11 

 
part thereof to be used for the preparation or dispensing of food. Notwithstanding the foregoing, but subject to the other terms and provisions of this Lease, Tenant may, with Landlord’s
prior written consent, which consent shall not be unreasonably withheld, install at its own cost and expense so-called hot-cold water fountains, coffee makers, microwave and toaster ovens and so-called Dwyer refrigerator-sink-stove combinations for
the preparation of beverages and foods, provided that no cooking, frying, etc., are carried on in the Premises to such extent as requires special exhaust venting, Tenant hereby acknowledging that the Building is not engineered to provide any such
special venting. So long as Tenant shall comply with Landlord’s reasonable security program for the Building and/or Complex, but subject to Landlord’s remedies under Article 21 of this Lease, Tenant shall have access to the Premises
twenty-four (24) hours per day, seven (7) days per week, during the term, except in the case of force majeure, emergencies or closures due to casualty or condemnation, within the Complex. Tenant shall have the right to secure the Premises
with an access card reader in the elevator cabin that accesses the Premises; provided, that (a) the installation, maintenance and repair of such system shall be done by Tenant at Tenant’s sole cost; (b) all work associated with such
installation shall be completed in accordance with plans approved by landlord (such approval not to be unreasonably withheld, conditioned or delayed) and (c) Tenant shall provide Landlord with duplicate keys, cards, and/or security codes to
insure that Landlord may access the Premises in accordance with the terms of the Lease. 
 5.2 Prohibited Uses. Notwithstanding any
other provision of this Lease, Tenant shall not use, or suffer or permit the use or occupancy of, or suffer or permit anything to be done in or anything to be brought into or kept in or about the Premises or the Building or any part thereof
(including, without limitation, any materials, appliances or equipment used in the construction or other preparation of the Premises and furniture and carpeting): (i) which would violate any of the covenants, agreements, terms, provisions and
conditions of this Lease or that are otherwise applicable to or binding upon the Premises; (ii) for any unlawful purposes or in any unlawful manner; (iii) which, in the reasonable judgment of Landlord shall in any way (a) impair the
appearance or reputation of the Building; or (b) impair, interfere with or otherwise diminish the quality of any of the Building services or the proper and economic heating, cleaning, ventilating, air conditioning or other servicing of the
Building or Premises, or with the use or occupancy of any of the other areas of the Building, or occasion discomfort, inconvenience or annoyance, or injury or damage to any occupants of the Premises or other tenants or occupants of the Building; or
(iv) which is inconsistent with the maintenance of the Building as an office building of the first class in the quality of its maintenance, use, or occupancy. Tenant shall not install or use any electrical or other equipment of any kind which,
in the reasonable judgment of Landlord, might cause any such impairment, interference, discomfort, inconvenience, annoyance or injury. 

5.3 Licenses and Permits. If any governmental license or permit shall be required for the proper and lawful conduct of Tenant’s
business, and if the failure to secure such license or permit would in any way affect Landlord, the Premises, the Building or Tenant’s ability to perform any of its obligations under this Lease, Tenant, at Tenant’s expense, shall duly
procure and thereafter maintain such license and submit the same to inspection by Landlord. Tenant, at Tenant’s expense, shall at all times comply with the terms and conditions of each such license or permit. Tenant shall furnish all data and
information to governmental authorities and Landlord as required in accordance with legal, regulatory, licensing or other similar requirements as they relate to Tenant’s use or occupancy of the Premises or the Building. 

 

	6.	RENT 

 During the term of this Lease, the Yearly Rent and other charges, at the rate
stated in Exhibit 1, shall be payable by Tenant to Landlord by monthly payments, as stated in Exhibit 1, in advance and without demand on the first day of each month for and in respect of such month. The rent and other charges reserved and
covenanted to be paid under this Lease shall commence on the Term Commencement Date. If, by reason of any provisions of this Lease, the rent reserved hereunder shall commence or terminate on any day other than the first day of a calendar month, the
rent for such calendar month shall be prorated. The rent and all other amounts payable to Landlord at the address provided in Exhibit 1 to this Lease or, if Landlord shall so direct in writing, to Landlord’s agent or nominee, in lawful money of
the United States which shall be legal tender for payment of all debts and dues, public and private, at 

  
 12 

 
the time of payment, at the office of the Landlord or such place as Landlord may designate, and the rent and other charges in all circumstances shall he payable without any setoff or deduction
whatsoever. Rental and any other sums due hereunder not paid on or before the date due or before the end of any grace or cure period provided in Section 21.7 shall bear interest for each month or fraction thereof from the due date until paid
computed at the annual rate of five percentage (5%) points over the so-called prime rate then currently from time to time charged to its most favored corporate customers by the largest national bank (N.A.) located in the city in which the
Building is located, or at any applicable lesser maximum legally permissible rate for debts of this nature. 
  

	7.	RENTABLE AREA 

 Total Rentable Area of the Premises, the Building and the Complex are
agreed to be the amounts set forth in Exhibit 1. Landlord reserves the right, throughout the term of the Lease, to recalculate the Total Rentable Area of the Building and/or the Complex. 

 

	8.	SERVICES FURNISHED BY LANDLORD 

 8.1 Electric Current. 

(a) As stated in Exhibit 1, Landlord will furnish to Tenant, as an incident of this Lease, electric current of not less than 480 volts - 400
amp disconnect for the operation of lighting fixtures, the 120-volt electrical outlets and the heat pumps and other equipment initially installed in the Premises and in connection with the Tenant’s Improvements. Tenant will reimburse Landlord
for the cost of such electric current as measured by a separate submeter which has been installed by Landlord. 
 (b) If Landlord is
providing electric current to Tenant, as aforesaid, then Tenant shall reimburse Landlord for the entire cost of such electric current as follows: 

(1) Commencing as of the Term Commencement Date and continuing until the procedures set forth in Paragraph 2 of this Article
8.1(b) are effected, Tenant shall pay to Landlord at the same time and in the same manner that it pays its monthly payments of Yearly Rent hereunder, estimated payments (i.e., based upon Landlord’s reasonable estimate) on account of
Tenant’s obligation to reimburse Landlord for electricity consumed in the Premises. 
 (2) Monthly after the Term
Commencement Date, Landlord shall determine the actual cost of electricity consumed by Tenant in the Premises (i.e. by reading Tenant’s sub-meter on a monthly basis and by applying an electric rate which shall not exceed the retail rate which
would have been payable by Tenant had Tenant obtained electric services directly from the utility company providing electric current to Landlord.) Landlord agrees to provide Tenant on a monthly basis with a written record of the monthly meter
reading. If the total of Tenant’s estimated monthly payments on account of such period, is less than the actual cost of electricity consumed in the Premises during such period, Tenant shall pay the difference to Landlord within fifteen
(15) days of when billed therefor. If the total of Tenant’s estimated monthly payments on account of such period is greater than the actual cost of electricity consumed in the Premises during such period, Tenant may credit the difference
against its next installment of rental or other charges due hereunder, provided that any excess credit shall be repaid to Tenant within a reasonable time following the expiration of the Lease term provided Tenant is not in default under this Lease.

 (3) After each adjustment, as set forth in Paragraph 2 above, the amount of estimated monthly payments on account of
Tenant’s obligation to reimburse Landlord for 

  
 13 

 
electricity in the Premises shall be adjusted based upon the actual cost of electricity consumed during the immediately preceding period. 

(c) If Landlord is furnishing Tenant electric current hereunder, Landlord, at any time, at its option and upon not less than sixty
(60) days’ prior written notice to Tenant, may discontinue such furnishing of electric current to the Premises; and in such case Tenant shall contract with the company supplying electric current for the purchase and obtaining by Tenant of
electric current directly from such company. In the event Tenant itself contracts for electricity with the supplier, pursuant to Landlord’s option as above stated. Landlord shall (i) permit its risers, conduits and feeders to the extent
available, suitable and safely capable, to be used for the purpose of enabling Tenant to purchase and obtain electric current directly from such company, (ii) without cost or charge to Tenant, make such alterations and additions to the
electrical equipment and/or appliances in the Building as such company shall specify for the purpose of enabling Tenant to purchase and obtain electric current directly from such company, and (iii) at Landlord’s expense, furnish and
install in or near the Premises any necessary metering equipment used in connection with measuring Tenant’s consumption of electric current and Tenant, at Tenant’s expense, shall maintain and keep in repair such metering equipment. 

(d) Whether or not Landlord is furnishing electric current to Tenant, if Tenant shall require electric current for use in the Premises in
excess of such reasonable quantity to be furnished for such use as hereinabove provided and if (i) in Landlord’s reasonable judgment, Landlord’s facilities are inadequate for such excess requirements or (ii) such excess use shall
result in an additional burden on the Building air conditioning system and additional cost to Landlord on account thereof, then, as the case may be, (x) Landlord, upon written request and at the sole cost and expense of Tenant, will furnish and
install such additional wire, conduits, feeders, switchboards and appurtenances as reasonably may be required to supply such additional requirements of Tenant if current therefor be available to Landlord, provided that the same shall be permitted by
applicable laws and insurance regulations and shall not cause damage to the Building or the Premises or cause or create a dangerous or hazardous condition or entail excessive or unreasonable alterations or repairs or interfere with or disturb other
tenants or occupants of the Building or (y) Tenant shall reimburse Landlord for such additional cost, as aforesaid, within thirty (30) days of billing therefor. 

(e) All of the light bulbs and electrical lamps in the Premises will be in good working order as of the Term Commencement Date. Landlord, at
Tenant’s expense and upon Tenant’s request, shall purchase and install all replacement lamps of types generally commercially available (including, but not limited to, incandescent and fluorescent) used in the Premises. 

(f) Except as otherwise provided herein, Landlord shall not in any way be liable or responsible to Tenant for any loss, damage or expense
which Tenant may sustain or incur if the quantity, character, or supply of electrical energy is changed or is no longer available or suitable for Tenant’s requirements. 

(g) Tenant agrees that it will not make any material alteration or material addition to the electrical equipment and/or appliances in the
Premises without the prior written consent of Landlord in each instance first obtained, which consent will not be unreasonably withheld, and using contractor(s) approved by Landlord, and will promptly advise Landlord of any other alteration or
addition to such electrical equipment and/or appliances. 
 8.2 Water. Landlord shall furnish hot and cold potable water for ordinary
Premises, cleaning, toilet, lavatory and drinking purposes and for the laboratory use as provided in the Work Scope. If Tenant requires, uses or consumes water for any purpose other than for the aforementioned purposes, Landlord may (i) assess
a reasonable charge for the additional water so used or consumed by Tenant or (ii) install a water meter and thereby measure Tenant’s water consumption for all purposes. In the latter event, Tenant shall pay the cost of the meter and the
cost of installation thereof and shall keep said meter and installation equipment in good working order and repair. Tenant agrees to pay for water consumed, as 

  
 14 

 
shown on said meter, together with the sewer charge based on said meter charges, as and when bills are rendered, and on default in making such payment Landlord may pay such charges and collect
the same from Tenant. All piping and other equipment and facilities for use of water outside the building core will be installed and maintained by Landlord at Tenant’s sole cost and expense. 

8.3 Elevators, Heat and Cleaning. Landlord shall: (i) provide necessary elevator facilities (which may be manually or
automatically operated, either or both, as Landlord may from time to time elect) on Mondays through Fridays, excepting Massachusetts and federal legal holidays, from 8:00 a.m. to 6:00 p.m. and on Saturdays, excepting legal holidays, from 8:00 a.m.
to 1:00 p.m. (called “business days”) and have one (1) elevator in operation available for Tenant’s use, non-exclusively, together with others having business in the Building, at all other times; (ii) furnish heat and air
conditioning (it being agreed that Tenant shall have control of the HVAC within its Premises) (substantially equivalent to the level being furnished in comparably aged similarly equipped office buildings in the same city) to the Premises during the
normal heating season; and (iii) cause the common areas of the Building to be cleaned on Monday through Friday (excepting Massachusetts or City of Cambridge legal holidays) in a manner consistent with cleaning standards generally prevailing in
the comparable office buildings in the City of Cambridge. All costs and expenses incurred by Landlord in connection with foregoing services shall be included as part of the Operating Costs (as defined below). Tenant shall be responsible, at its sole
cost and expense, for providing cleaning and janitorial services to the Premises in a neat and first-class manner consistent with the cleaning standards generally prevailing in the comparable buildings in the City of Cambridge using an insured
contractor or contractors selected by Tenant and approved in writing by Landlord and such provider shall not interfere with the use and operation of the Building or Complex by Landlord or any other tenant or occupant thereof. 

8.4 Air Conditioning. Landlord shall through the air conditioning equipment of the Building furnish to and distribute in the Premises
air conditioning as normal seasonal changes may require air conditioning may reasonably be required for the comfortable occupancy of the Premises by Tenant it being acknowledged by tenant, however, that Tenant shall control the HVAC within its
Premises. The make-up air unit servicing solely the Premises shall be capable of providing 1.5 CFM per square foot of 100% outdoor air to the laboratory portion only of the Premises that are constructed as part of Tenant’s Improvements. The
HVAC system servicing the office portion of the Premises shall be sized to meet the applicable building codes related thereto. Tenant agrees to lower and close the blinds or drapes when necessary because of the sun’s position, whenever the air
conditioning system is in operation, and to cooperate fully with Landlord with regard to, and to abide by all the reasonable regulations and requirements which Landlord may prescribe for the proper functioning and protection of the air conditioning
system. 
 8.5 Additional Heat and Air Conditioning Services. Landlord will use reasonable efforts upon reasonable advance written
notice from Tenant of its requirements in that regard, to furnish additional heat or air conditioning services to the Premises on days and at times other than as above provided. Tenant will pay to Landlord a reasonable charge for any such additional
heat or air conditioning service required by Tenant. 
 8.6 Additional Air Conditioning Equipment. In the event Tenant requires
additional air conditioning other than as set forth in the Work Scope, such additional air conditioning equipment will be installed, but only if, in Landlord’s reasonable judgment, the same will not cause damage or injury to the Building or
create a dangerous or hazardous condition or entail excessive or unreasonable alterations, repairs or expense or interfere with or disturb other tenants. At Landlord’s sole election, such equipment will either be installed: 

(a) by Landlord at Tenant’s expense and Tenant shall reimburse Landlord in such an amount as will compensate it for the actual,
out-of-pocket cost incurred by it in operating, maintaining, repairing and replacing, if necessary, such additional air conditioning equipment. At Landlord’s election, such equipment shall (i) be maintained, repaired and replaced by Tenant
at Tenant’s sole cost and expense, 

  
 15 

 and (ii) throughout the term of this Lease, Tenant shall, at Tenant’s sole cost and expense, purchase
and maintain a service contract for such equipment from a service provider approved by Landlord. Tenant shall obtain Landlord’s prior written approval of both the form of service contract and of the service provider; or 

(b) by Tenant, subject to Landlord’s prior approval of Tenant’s plans and specifications for such work. In such event: (i) such
equipment shall be maintained, repaired and replaced by Tenant at Tenant’s sole cost and expense, and (ii) throughout the term of this Lease, Tenant shall, at Tenant’s sole cost and expense, purchase and maintain a service contract
for such equipment from a service provider approved by Landlord Tenant shall obtain Landlord’s prior written approval of both the form of service contract and of the service provider. 

8.7 Repairs. Except as otherwise provided in Articles 18 and 20, and subject to Tenant’s obligations in Article 14, Landlord shall
keep and maintain the roof, exterior walls, structural floor slabs, columns, elevators, glass of exterior windows (except to the extent such repair was necessitated by the act or negligence of Tenant, its employees, agents or contractors in which
case Tenant shall repair), public stairways and corridors, public lavatories, and other common equipment (including, without limitation, sanitary, electrical, heating, air conditioning, or other systems) serving the Building, the Premises and the
Common Areas in good operating condition and repair. Landlord shall keep the paved portions of the Common Areas reasonably free of ice and snow. 

8.8 Interruption or Curtailment of Services. When necessary by reason of accident or emergency, or for repairs, alterations,
replacements or improvements which in the reasonable judgment of Landlord are desirable or necessary to be made, or of difficulty or inability in securing supplies or labor, or of strikes, or of any other cause beyond the reasonable control of
Landlord, whether such other cause be similar or dissimilar to those hereinabove specifically mentioned until said cause has been removed, Landlord reserves the right to interrupt, curtail, stop or suspend (i) the furnishing of heating,
elevator, air conditioning and cleaning services and (ii) the operation of the plumbing and electric systems. Landlord shall exercise reasonable diligence to eliminate the cause of any such interruption, curtailment, stoppage or suspension, but
there shall be no diminution or abatement of rent or other compensation due from Landlord to Tenant hereunder, nor shall this Lease be affected or any of the Tenant’s obligations hereunder reduced, and the Landlord shall have no responsibility
or liability for any such interruption, curtailment, stoppage, or suspension of services or systems. 
 An “Abatement Event” shall
occur in the event (i) the Premises shall lack any service which Landlord is required to provide hereunder thereby rendering the Premises untenantable for the entirety of the Eligibility Period (as defined below), (ii) such lack of service
was not caused by Tenant, its employees, contractors, invitees or agents; (iii) Tenant in fact ceases to use the entire Premises for the entirety of the Eligibility Period; and (iii) such interruption of service was the result of causes,
events or circumstances within the Landlord’s reasonable control and the cure of such interruption is within Landlord’s reasonable control. Tenant shall give Landlord notice (“Abatement Notice”) of any such Abatement Event, and
if such Abatement Event continues beyond the “Eligibility Period” (as that term is defined below), then the Yearly Rent and Tenant’s other monetary obligations to Landlord shall be abated entirely or reduced, as the case may be, after
expiration of the Eligibility Period for such time that Tenant continues to be so prevented from using, and does not use, the Premises or a portion thereof, in the proportion that the rentable area of the portion of the Premises that Tenant is
prevented from using, and does not use, bears to the total rentable area of the Premises; provided, however, in the event that Tenant is prevented from using, and does not use, a portion of the Premises for a period of time in excess of the
Eligibility Period and the remaining portion of the Premises is not sufficient to allow Tenant to effectively conduct its business therein, and if Tenant does not conduct its business from such remaining portion, then for such time after expiration
of the Eligibility Period during which Tenant is so prevented from effectively conducting its business therein, Yearly Rent and Tenant’s other monetary obligations to Landlord shall be abated entirely for such time as Tenant continues to be so
prevented from using, and does not use, the Premises. The term “Eligibility Period” shall mean a period of ten (10) consecutive days after Landlord’s receipt of any Abatement Notice(s). 

  
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 8.9 Energy Conservation. Notwithstanding anything to the contrary in this Article 8 or in
this Lease contained, Landlord may institute, and Tenant shall comply with, such policies, programs and measures as may be necessary, required, or expedient for the conservation and/or preservation of energy or energy services, or as may be
necessary or required to comply with applicable codes, rules regulations or standards so long as they do not materially interfere with Tenant’s use of or reasonable comfort within the Premises. 

 

	9.	ESCALATION 

 9.1 Definitions. As used in this Article 9, the words and terms which
follow mean and include the following: 
 (a) “Operating Year” shall mean a calendar year in which occurs any part of the term of
this Lease. 
 (b) “Tenant’s Proportionate Building Share” shall initially be the figure as stated in Exhibit 1.
Tenant’s Proportionate Building Share is the ratio of the Total Rentable Area of the Premises to the aggregate Total Rentable Area of the Building, from time to time. As physical changes or modifications to the Building occurs, Tenant’s
Proportionate Building Share shall be adjusted to equal the then current ratio of the Total Rentable Area of the Premises to the aggregate Total Rentable Area within the Building which is then completed and as to which a certificate of occupancy is
issued. 
 (c) “Tenant’s Proportionate Common Share” shall initially be the figure as stated in Exhibit 1. Tenant’s
Proportionate Common Share is the ratio of the Total Rentable Area of the Premises to the aggregate Total Rentable Area, from time to time, of all buildings within the Complex which have been completed and for which a certificate of occupancy has
been issued. 
 (d) “Taxes” shall mean the real estate taxes and other taxes, levies and assessments imposed upon the Building and
the Common Areas of the Complex and upon any personal property of Landlord used in the operation thereof, or Landlord’s interest in the Building, the Common Areas, or such personal property; charges, fees and assessments for transit, housing,
police, fire or other governmental services or purported benefits to the Building and/or the Common Areas; service or user payments in lieu of taxes; and any and all other taxes, levies, betterments, assessments and charges arising from the
ownership, leasing, operating, use or occupancy of the Building, the Common Areas or based upon rentals derived therefrom, which are or shall be imposed by Federal, State, Municipal or other authorities. As of the Execution Date, “Taxes”
shall not include any franchise, rental, income or profit tax, capital levy or excise, provided, however, that any of the same and any other tax, excise, fee, levy, charge or assessment, however described, that may in the future be levied, or
assessed as a substitute for or an addition to, in whole or in part, any tax, levy or assessment which would otherwise constitute “Taxes,” whether or not now customary or in the contemplation of the parties on the Execution Date of this
Lease, shall constitute “Taxes,” but only to the extent calculated as if the Complex is the only real estate owned by Landlord. “Taxes” shall also include expenses of tax abatement or other proceedings contesting assessments or
levies. The parties acknowledge that, as of the Execution Date, Taxes are based upon several separate tax bills affecting the Complex. Taxes shall be allocated by Landlord, in Landlord’s reasonable judgment, among the Building (the portion of
Taxes allocable to the Building being referred to herein as “Building Taxes”), the other buildings of the Complex, and the Common Areas (the portion of Taxes allocable to the Common Areas being referred to herein as “Common Area
Taxes”). 
 (e) “Tax Period” shall be any fiscal/tax period in respect of which Taxes are due and payable to the appropriate
governmental taxing authority, any portion of which period occurs during the term of this Lease, the first such Period being the one in which the Term Commencement Date occurs. 

(f) “Operating Costs”: 

  
 17 

 (1) Definition of Operating Costs. “Operating Costs” shall mean
all costs incurred and expenditures of whatever nature made by Landlord in the operation and management, for repair and replacements, cleaning and maintenance of the Building, the Complex, and the Common Areas of the Complex including, without
limitation, vehicular and pedestrian passageways related to the Complex, related equipment facilities and appurtenances, elevators, cooling and heating equipment. In the event that Landlord or Landlord’s managers or agents perform services
directly for the benefit of the Complex off-site which would otherwise be performed on-site (e.g., accounting), the cost of such services shall be reasonably allocated among the properties directly benefiting from such service and shall be included
in Operating Costs. Landlord shall have the right but not the obligation, from time to time, to equitably allocate some or all of the Operating Costs among different tenants of the Building or properties (the “Cost Pools”). Such Cost Pools
may include, but shall not be limited to, tenants that share particular systems or equipment or tenants that are similar users of particular systems or equipment such as by way of example but not limitation the office space tenants of the Building
or properties, the laboratory tenants of the Building or properties and the retail space tenants of the Building or properties. Operating Costs shall include, without limitation, those categories of “Specifically Included Operating Costs,”
as set forth below, but shall not include “Excluded Costs,” as hereinafter defined. 
 (2) Definition of
Excluded Costs. “Excluded Costs” shall be defined as mortgage charges, brokerage commissions, salaries of executives and owners not directly employed in the management/operation of the Complex, the cost of work done by Landlord for a
particular tenant for which Landlord has the right to be reimbursed by such tenant, and, subject to Subparagraph (3) below, such portion of expenditures as are not properly chargeable against income, and the following: 

(i) bad debt expenses and interest, principal, points and fees on debts or amortization on any mortgage or other debt
instrument encumbering the Building or Complex mortgages (except to the extent that the same are included in the Annual Charge-Off of capital expenditures which are permitted to be included in Operating Costs; 

(ii) costs incurred by Landlord to the extent that Landlord is reimbursed by insurance proceeds or is otherwise reimbursed;

 (iii) advertising and promotional expenditures and costs of acquisition and maintenance of signs in or on the Building
identifying the owner of the Building or other tenants; 
 (iv) marketing costs, including leasing commissions,
attorneys’ fees (in connection with the negotiation and preparation of letters, deal memos, letters of intent, leases, subleases and/or assignments), space planning costs, and other costs and expenses incurred in connection with the lease,
sublease and/or assignment negotiations and transactions with present or prospective tenants or other occupants of the Building; 

(v) costs, including permit, license and inspection costs, incurred with respect to the installation of other tenants’ or
other occupants’ improvements or incurred in renovating or otherwise improving, decorating, painting or redecorating vacant space for tenants or other occupants of the Building or Complex; 

  
 18 

 (vi) costs incurred by Landlord due to the violation by Landlord or any tenant
of the terms and conditions of any lease of space in the Building; 
 (vii) amounts paid to Landlord or to subsidiaries or
affiliates of Landlord for goods and/or services in the Building or Complex to the extent the same exceeds the costs of such goods and/or services rendered by unaffiliated third parties on a competitive basis (it being agreed, however, that for
periods when the Complex is not managed by an unaffiliated third-party, a management fee equal to three percent (3%) of gross collected revenues from the Complex paid to an affiliate of Landlord may be included in Operating Costs); 

(viii) costs incurred in connection with upgrading the Building or Complex to comply with laws, rules, regulations and codes
in effect prior to the Term Commencement Date; 
 (ix) costs arising from the negligence or willful misconduct of Landlord
or other tenants or occupants of the Building or Complex or their respective agents, employees, licensees, contractors or providers of materials or services. 

(x) rentals for items which if purchased, rather than rented, would constitute a capital cost otherwise excluded hereunder, to
the extent such rental exceeds the Annual Charge-Off which would have been permitted to be included in Operating Costs for the rented item had Landlord purchased such item rather than leasing such item and provided such capital cost would have
otherwise been included in Operating Costs; 
 (xi) costs arising from Landlord’s charitable or political
contributions; 
 (xii) costs arising from latent defects or repairs to the building or Complex; 

(xiii) costs for sculpture, paintings or other objects of art; 

(xiv) costs associated with the operation of the business of the entity which constitutes Landlord as the same are
distinguished from the costs of operation of the Building, or Complex including accounting (except for the cost of at least one (1) independent audit annually relating to the Building or Complex) and legal matters, costs of defending any
lawsuits with any mortgagee (except as the actions of Tenant may be in issue), costs of selling, syndicating, financing, mortgaging or hypothecating any of Landlord’s interest in the Building or Complex, costs incurred in connection with any
disputes between Landlord and its employees, between Landlord and Building management, or between Landlord and other tenants or occupants 

(3) Capital Expenditures. 

(i) Replacements. If, during the term of this Lease, Landlord shall replace any capital items or make any capital expenditures
which are performed to improve operating efficiency of the Building or to comply with laws first applicable to the Building after the Term Commencement Date (collectively called “capital expenditures”) the total amount of which is not
properly includible in Operating Costs for the Operating Year to which they were made, 

  
 19 

 
there shall nevertheless be included in such Operating Costs and in Operating Costs for each succeeding Operating Year the amount, if any, by which the Annual Charge-Off (determined as
hereinafter provided) of such capital expenditure (less insurance proceeds, if any, collected by Landlord by reason of damage to, or destruction of the capital item being replaced) exceeds the Annual Charge-Off of the capital expenditure for the
item being replaced. 
 (ii) Annual Charge-Off. “Annual Charge-Off’ shall be defined as the annual amount
of principal and interest payments which would be required to repay a loan (“Capital Loan”) in equal monthly installments over the Useful Life, as hereinafter defined, of the capital item in question on a direct reduction basis at an
annual interest rate equal to the Capital Interest Rate, as hereinafter defined, where the initial principal balance is the cost of the capital item in question. Notwithstanding the foregoing, if Landlord reasonably concludes on the basis of
engineering estimates that a particular capital expenditure will effect savings in Building operating expenses including, without limitation, energy-related costs, and that such projected savings will, on an annual basis (“Projected Annual
Savings”), exceed the Annual Charge-Off of such capital expenditure computed as aforesaid, then and in such events, the Annual Charge-Off shall be increased to an amount equal to the Projected Annual Savings; and in such circumstances, the
increased Annual Charge-Off (in the amount of the Projected Annual Savings) shall be made for such period of time as it would take to fully amortize the cost of the capital item in question, together with interest thereon at the Capital Interest
Rate as aforesaid, in equal monthly payments, each in the amount of one-twelfth (1/12th) of the Projected Annual Savings, with such payments being applied first to interest and the balance to principal. 

(iii) Useful Life. “Useful Life” shall be reasonably determined by Landlord in accordance with generally
accepted accounting principles and practices in effect at the time of acquisition of the capital item. 
 (iv) Capital
Interest Rate. “Capital Interest Rate” shall be defined as an annual rate of either one percentage point over the AA Bond rate (Standard & Poor’s corporate composite or, if unavailable, its equivalent) as reported in the
financial press at the time the capital expenditure is made or, if the capital item is acquired through third-party financing, then the actual (including fluctuating) rate paid by Landlord in financing the acquisition of such capital item. 

(4) Specifically Included Categories or Operating Costs shall include, but not be limited to, the following: 

Taxes (other than real estate taxes): Sales, Federal Social Security. Unemployment and Old Age Taxes and contributions and
State Unemployment taxes and contributions accruing to and paid by the Landlord on account of all employees of Landlord and/or Landlord’s managing agent, who are employed in, about or on account of the Complex, except for those officers and
employees with titles above the level of Building Manager and except that taxes levied upon the net income of the Landlord and taxes withheld from employees, and “Taxes” as defined in Article 9.1 (d) shall not be included herein. 

Water: all charges and rates connected with water supplied to the Building and related sewer use charges. 

Heat and Air Conditioning: All charges connected with heat and air conditioning supplied to the Building. 

  
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 Wages: Wages and cost of all employee benefits of all employees of the Landlord
and/or Landlord’s managing agent who are employed in or directly on account of the Building, except for those officers and employees with titles above the level of Building Manager. 

Cleaning: The cost of labor (including third party janitorial contracts), supplies, tools and material for cleaning the
Building and Complex. 
 Elevator Maintenance: All expenses for or on account of the upkeep and maintenance of all elevators
in the Building. 
 Management Fee: The cost of professional management of the Complex, not to exceed 3% of gross income
received by Landlord from the Complex for such Operations Year. 
 Administrative Costs: The cost of office expense for the
management of the Complex, including, without limitation, rent, business supplies and equipment. 
 Electricity: The cost of
all electric current for the operation of any machine, appliance or device in the Building or Complex and used for the operation of the Premises and the Building, including the cost of electric current for the elevators, lights, air conditioning and
heating, but not including electric current which is paid for directly to the utility by the user/tenant in the Building or for which the user/tenant reimburses Landlord. (If and so long as Tenant is billed directly by the electric utility for its
own consumption as determined by its separate meter, or billed directly by Landlord as determined by a check meter, then Operating Costs shall include only Building and public area electric current consumption and not any demised Premises electric
current consumption.) Wherever separate metering is unlawful, prohibited by utility company regulation or tariff or is otherwise impracticable, relevant consumption figures for the purposes of this Article 9 shall be determined by fair and
reasonable allocations and engineering estimates made by Landlord. 
 Insurance, etc.: Fire, casualty, liability, rent loss
and such other insurance as may from, time to time be required by lending institutions on first-class office buildings in the City or Town wherein the Building is located and all other expenses customarily incurred in connection with the operation
and maintenance of first-class office buildings in the City or Town wherein the Building is located including, without limitation, insurance deductible amounts and rental costs associated with the Building’s management office. ; 
 (5) Definitions of Building Operating Costs and Common Area Operating
Costs. “Building Operating Costs” shall be defined as the amount of Operating Costs allocable to the Building in any Operating Year. “Common Area Operating Costs” shall be defined as the amount of Operating Costs allocable to
the Common Areas in any Operating Year. All Operating Costs incurred by Landlord in respect of the Complex shall be allocated, in Landlord’s reasonable judgment, among the Building, the other buildings of the Complex, and the Common Areas. 

(6) Gross-Up Provision. Notwithstanding the foregoing, in determining the amount of Operating Costs for any calendar
year or any portion thereof falling within the term, if less than ninety-five percent (95%) of the Rentable Area of the Building shall have been occupied by tenants at any time during the period in question, then, at Landlord’s election,
Operating Costs for such period shall be adjusted to equal the amount Operating Costs would have been for such period had occupancy been ninety-five 

  
 21 

 
percent (95%) throughout such period. The extrapolation of Operating Costs under this paragraph shall be performed by appropriately adjusting the cost of those components of Operating Costs
that are impacted by changes in the occupancy of the Building. It is agreed that only the following Operating Costs shall be subject to this gross-up provision: managements fees, water and sewer charges (except to the extent not directly metered to
a particular tenant) and the cost of refuse and recycling removal. 
 9.2 Tax Share. Commencing as of the Term Commencement Date and
continuing thereafter with respect to each Tax Year occurring during the term of the Lease, Tenant shall pay to Landlord, with respect to any Tax Period, the sum of: (x) Tenant’s Proportionate Building Share of Building Taxes for such Tax
Period, plus (y) Tenant’s Proportionate Common Share of Common Area Taxes for such Tax Period, such sum being hereinafter referred to as “Tax Share”. Tax Share shall be due when billed by Landlord. In implementation and not in
limitation of the foregoing, Tenant shall remit to Landlord pro rata monthly installments on account of projected Tax Share, calculated by Landlord on the basis of the most recent Tax data or budget available. If the total of such monthly
remittances on account of any Tax Period is greater than the actual Tax Share for such Tax Period, Tenant may credit the difference against the next installment of rental or other charges due to Landlord hereunder. If the total of such remittances
is less than the actual Tax Share for such Tax Period, Tenant shall pay the difference to Landlord within fifteen (15) days of when billed therefor. 

Appropriate credit against Tax shall be given for any refund obtained by reason of a reduction in any Taxes by the Assessors or the
administrative, judicial or other governmental agency responsible therefor. The original computations, as well as reimbursement or payments of additional charges, if any, or allowances, if any, under the provisions of this Article 9.2 shall be based
on the original assessed valuations with, adjustments to be made at a later date when the tax refund , if any, shall be paid to Landlord by the taxing authorities. Expenditures for legal fees and for other similar or dissimilar expenses incurred in
obtaining the tax refund may be charged against the tax refund before the adjustments are made for the Tax Period. 
 9.3 Operating
Expense Share. Commencing as of the Term Commencement Date and continuing thereafter with respect to each Operating Year occurring during the term of the Lease, Tenant shall pay to Landlord, with respect to any Operating Year, the sum of:
(x) Tenant’s Proportionate Building Share of Building Operating Costs for such Operating Year, plus (y) Tenant’s Proportionate Common Share of Common Operating Costs for such Operating Year, such sum being hereinafter referred to
as “Operating Expense Share”. In implementation and not in limitation of the foregoing, Tenant shall remit to Landlord pro rata monthly installments on account of projected Operating Expense Share, calculated by Landlord on the basis of
the most recent Operating Costs data or budget available. If the total of such monthly remittances on account of any Operating Year is greater than the actual Operating Expense Share for such Operating Year, Landlord may credit the difference
against the next installment of rent or other charges due to Landlord hereunder. If the total of such remittances is less than actual Operating Expense Share for such Operating Year, Tenant shall pay the difference to Landlord within thirty
(30) days of billing therefor. 
 9.4 Part Years. If the Term Commencement Date or the Termination Date occurs in the middle of
an Operating Year or Tax Period, Tenant shall be liable for only that portion of the Operating Expense or Tax Share as the case may be, in respect of such Operating Year or Tax Period represented by a fraction, the numerator of which is the number
of days of the herein term which falls within the Operating Year or Tax Period and the denominator of which is three hundred sixty-five (365), or the number of days in said Tax Period, as the case may be. 

9.5 Effect of Taking. In the event of any taking of the Building or the land upon which it stands under circumstances whereby this
Lease shall not terminate under the provisions of Article 20 then, Tenant’s Proportionate Building Share and Tenant’s Proportionate Common Share shall be adjusted appropriately to reflect the proportion of the Premises and/or the Building
remaining after such taking. 

  
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 9.6 Survival. Any obligations under this Article 9 which shall not have been paid at the
expiration or sooner termination of the term of this Lease shall survive such expiration and shall be paid when and as the amount of same shall be determined to be due. 
  

	10.	CHANGES OR ALTERATIONS BY LANDLORD 

 Landlord reserves the right, exercisable by itself
or its nominee, at any time and from time to time without the same constituting an actual or constructive eviction and without incurring any liability to Tenant therefor or otherwise affecting Tenant’s obligations under this Lease, to make such
changes, alterations, additions, improvements, repairs or replacements in or to: (i) the Building (including the Premises) and the fixtures and equipment thereof, (it) the street entrances, halls, passages, elevators, escalators, and stairways
of the Building, and (iii) the Common Areas, and facilities located therein, as Landlord may deem necessary or desirable, and to change the arrangement and/or location of entrances or passageways, doors and doorways, and corridors, elevators,
stairs, toilets, or other public parts of the Building and/or the Common Areas, provided, however, that there be no unreasonable obstruction of the right of access to, or unreasonable interference with the use and enjoyment of, the Premises by
Tenant. Nothing contained in this Article 10 shall be deemed to relieve Tenant of any duty, obligation or liability of Tenant with respect to making any repair, replacement or improvement or complying with any law, order or requirement of any
governmental or other authority. Landlord reserves the right to adopt and at any time and from time to time to change the name or address of the Building. Neither this Lease nor any use by Tenant shall give Tenant any right or easement for the use
of any door, passage, concourse, walkway or parking area within the Building or in the Common Areas, and the use of such doors, passages, concourses, walkways, parking areas and such conveniences may be regulated or discontinued at any time and from
time to time by Landlord without notice to Tenant and without affecting the obligation of Tenant hereunder or incurring any liability to Tenant therefor, provided, however, that there be no unreasonable obstruction of the right of access to, or
unreasonable interference with the use of the Premises by Tenant. 
 If at any time any windows of the Premises are temporarily closed or
darkened for any reason whatsoever including but not limited to, Landlord’s own acts, Landlord shall not be liable for any damage Tenant may sustain thereby and Tenant shall not be entitled to any compensation therefor nor abatements of rent
nor shall the same release Tenant from its obligations hereunder nor constitute an eviction. 
  

	11.	FIXTURES, EQUIPMENT AND IMPROVEMENTS-REMOVAL BY TENANT 

 Except for the items listed on
Exhibit 6, which are the personal property of Tenant and other items of personal property that Tenant notifies Landlord in writing shall be added to Exhibit 6 in the future (collectively, “Tenant’s Personal Property”), all fixtures,
equipment, improvements and appurtenances attached to or built into the Premises prior to or during the term, whether by Landlord at its expense or at the expense of Tenant (either or both) or by Tenant shall be and remain part of the Premises and
shall not be removed by Tenant during or at the end of the term unless Landlord at the time of an approval of an alteration otherwise elects to require Tenant to remove such fixtures, equipment, improvements and appurtenances, in accordance with
Articles 12 and/or 22 of the Lease. Except for Tenant’s Personal Property, all electric, communication, radio, plumbing, heating and sprinkling systems, fixtures and outlets, vaults, paneling, molding, radiator enclosures, cork, rubber,
linoleum and composition floors, ventilating, silencing, air conditioning and cooling equipment, shall be deemed to be included in such fixtures, equipment, improvements and appurtenances, whether or not attached to or built into the Premises. Where
not built into the Premises, all removable electric fixtures, carpets, drinking or tap water facilities, furniture, or trade fixtures or business equipment or Tenant’s inventory or stock in trade shall not be deemed to be included in such
fixtures, equipment, improvements and appurtenances and may be, and upon the request of Landlord as set forth above, will be removed by Tenant upon the condition that such removal shall not materially damage the Premises or the Building and that the
cost of repairing any damage to the Premises or the Building arising from installation or such removal shall be paid by Tenant. If any of Tenant’s Personal Property is affixed to or plumbed to the Premises, Tenant shall not materially damage
the Premises or the Building upon removal of such Tenant’s Personal Property and the cost of repairing any damage to the Premises or the Building arising from installation or such removal of Tenant’s Personal Property shall be

  
 23 

 
paid by Tenant. The covenants of this Section shall survive the expiration or earlier termination of the Term. 
  

	12.	ALTERATIONS AND IMPROVEMENTS BY TENANT 

 Tenant shall make no alterations, decorations,
installations, removals, additions or improvements in or to the Premises without Landlord’s prior written consent and unless made by contractors or mechanics approved by Landlord. No installations or work shall be undertaken or begun by Tenant
until: (i) Landlord has approved written plans and specifications and a time schedule for such work; and (ii) Tenant has made provision for either written waivers of liens from all contractors, laborers and suppliers of materials for such
installations or work, the filing of lien bonds on behalf of such contractors, laborers and suppliers, or other appropriate protective measures approved by Landlord. No amendments or additions to such plans and specifications shall be made without
the prior written consent of Landlord. Landlord’s consent and approval required under this Article 12 shall not be unreasonably withheld, conditioned or delayed, Landlord’s approval is solely given for the benefit of Landlord and neither
Tenant nor any third party shall have the right to rely upon Landlord’s approval of Tenant’s plans for any purpose whatsoever. Without limiting the foregoing, Tenant shall be responsible for all elements of the design of Tenant’s
plans (including, without limitation, compliance with law, functionality of design, the structural integrity of the design, the configuration of the Premises and the placement of Tenant’s furniture, appliances and equipment), and
Landlord’s approval of Tenant’s plans shall in no event relieve Tenant of the responsibility for such design. Landlord shall have no liability or responsibility for any claim, injury or damage alleged to have been caused by the particular
materials, whether building standard or non-building standard, appliances or equipment selected by Tenant, in connection with any work performed by or on behalf of Tenant in the Premises including, without limitation, furniture, carpeting, copiers,
laser printers, computers and refrigerators. Any such work, alterations, decorations, installations, removals, additions and improvements shall be done at Tenant’s sole expense and at such times and in such manner as Landlord may from time to
time designate, if Tenant shall make any alterations, decorations, installations, removals, additions or improvements, then Landlord may elect at the time that approval is given thereto or notice thereof is sent to Landlord to require the Tenant at
the expiration or sooner termination of the term of this Lease to restore the Premises to substantially the same condition as existed at the Term Commencement Date. Tenant shall pay, as an additional charge, the entire increase in real estate taxes
on the Building which the applicable taxing authority determines, at any time prior to or after the Term Commencement Date, result from or be attributable to any alteration, addition or improvement to the Premises made by or for the account of
Tenant. Notwithstanding the foregoing, Landlord’s consent shall not be required (but Tenant shall be required to notify Landlord in writing of such prior to commencement of work) for any alteration that satisfies all of the following criteria
(a “Limited Alteration”): (1) is an interior alteration of a non-structural nature to the Premises; (2) is not visible from the exterior of the Premises or Building; (3) will not affect the systems serving any portion of the
Building (including, without limitation, any fire, safety, telecommunication, electrical, mechanical, ventilation or plumbing systems of the Building) and will not affect the structure of the Building; (4) does not cause any material
penetration in or otherwise affect any walls, floors, roofs or other structural elements of the Building, (5) does not require the issuance of any permits, licenses, approvals or the like, (6) does not require unusual expense to readapt
the premises to normal office or laboratory use at the termination; and (7) does not cost more than $25,000.00 in the aggregate together with the costs of any other Limited Alterations previously undertaken; provided that all work shall be done
by contractors reasonably approved by Landlord, 
 If, as a result of any alterations, decorations, installations, removals, additions and
improvements made by Tenant, Landlord is obligated to comply with the Americans With Disabilities Act or any other federal, state or local laws or regulations and such compliance requires Landlord to make any improvement or alteration to any portion
of the Building or the Complex, as a condition to Landlord’s consent, Landlord shall have the right to require Tenant to pay to Landlord prior to the construction of any such alteration, decoration, installation, removal, addition or
improvement by Tenant, the entire cost of any improvement or alteration Landlord is obligated to complete by such law or regulation. 

  
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 Without limiting any of the terms hereof, Landlord will not approve any alteration, decoration,
installation, removal, addition or improvement requiring unusual expense to readapt the Premises to normal office use on lease termination or increasing the cost of construction, insurance or Taxes on the Building or of Landlord’s services to
the Premises, unless Tenant first gives assurances or security acceptable to Landlord that such re-adaptation will be made prior to such termination without expense to Landlord and makes provisions acceptable to Landlord for payment of such
increased cost. 
  

	13.	TENANT’S CONTRACTORS-MECHANICS’ AND OTHER LIENS-STANDARD OF TENANT’S PERFORMANCE-COMPLIANCE WITH LAWS 

Whenever Tenant shall make any alterations, decorations, installations, removals, additions or improvements in or to the Premises—whether
such work be done prior to or after the Term Commencement Date—Tenant will strictly observe the following covenants and agreements: 

(a) Tenant agrees that it will not, either directly or indirectly, use any contractors and/or materials if their use will create any
difficulty, whether in the nature of a labor dispute or otherwise, with other contractors and/or labor engaged by Tenant or Landlord or others in the construction, maintenance and/or operation of the Building or any part thereof. 

(b) In no event shall any material or equipment be incorporated in or added to the Premises, so as to become a fixture or otherwise a part of
the Building, in connection with any such alteration, decoration, installation, addition or improvement which is subject to any lien, charge, mortgage or other encumbrance of any kind whatsoever or is subject to any security interest or any form of
title retention agreement. No installations or work shall be undertaken or begun by Tenant until Tenant has made provision for written waiver of liens from all contractors, laborers and suppliers of materials for such installations or work, and
taken other appropriate protective measures approved by Landlord. Any mechanic’s lien filed against the Premises or the Building for work claimed to have been done for, or materials claimed to have been furnished to, Tenant shall be discharged
by Tenant within ten (10) days thereafter, at Tenant’s expense by filing the Bond required by law or otherwise. If Tenant fails so to discharge any lien, Landlord may do so at Tenant’s expense and Tenant shall reimburse Landlord for
any expense or cost incurred by Landlord in so doing within thirty (30) days after rendition of a bill therefor. 
 (c) All
installations or work done by Tenant shall be at its own expense and shall at all times comply with (i) laws, rules, orders and regulations of governmental authorities having jurisdiction thereof; (ii) orders, rules and regulations of any
Board of Fire Underwriters, or any other body hereafter constituted exercising similar functions, and governing insurance rating bureaus; (iii) rules and regulations of Landlord of which Tenant has received written notice; and (iv) plans
and specifications prepared by and at the expense of Tenant theretofore submitted to and approved by Landlord as provided above. 
 (d)
Tenant shall procure and deliver to Landlord copies of all necessary permits before undertaking any work in the Premises; do all of such work in a good and workmanlike manner, employing materials of good, quality and complying with all governmental
requirements; and defend, save harmless, exonerate and indemnify Landlord from all injury, loss or damage to any person or property, occasioned by or growing out of such work. Tenant shall cause contractors employed by Tenant to carry Worker’s
Compensation Insurance in accordance with statutory requirements, Automobile Liability Insurance and, naming Landlord as an additional insured, Commercial General Liability Insurance covering such contractors on or about the Premises in the amounts
stated in Article 15 hereof or in such other reasonable amounts as Landlord shall require and to submit certificates evidencing such coverage to Landlord prior to the commencement of such work. 

 

	14.	REPAIRS BY TENANT-FLOOR LOAD 

 14.1 Repairs by Tenant. Tenant shall keep all and
singular the Premises neat and clean (including periodic rug shampoo and waxing of tiled floors and cleaning of blinds and drapes) and in such 

  
 25 

 
repair, order and condition as the same are in on the Term Commencement Date or may be put in during the term hereof, reasonable use and wearing thereof and damage by fire or by other casualty
excepted. For purposes of this Lease, the terms “reasonable use and wearing” and “ordinary wear and use” (as referred to in Article 22 herein) constitute that normal, gradual deterioration which occurs due to aging and ordinary
use of the Premises despite reasonable and timely maintenance and repair, but in no event shall the aforementioned terms excuse Tenant from its duty to keep the Premises in good maintenance and repair or otherwise usable, serviceable and tenantable
as required in the Lease. Tenant shall be solely responsible for the proper maintenance of all equipment and appliances operated by Tenant, including, without limitation, copiers, laser printers, computers, refrigerators, the Generator, the ANS and
the RODI. Tenant shall make, as and when needed as a result of misuse by, or neglect or improper conduct of, Tenant or Tenant’s servants, employees, agents, contractors, invitees, or licensees or otherwise, all repairs in and about the Premises
necessary to preserve them in such repair, order and condition (damage by fire and casualty excepted), which repairs shall be in quality and class equal to the original work. Landlord may elect, at the expense of Tenant, to make any such repairs or
to repair any damage or injury to the Building or the Premises caused by moving property of Tenant in or out of the Building, or by installation or removal of furniture or other property, or by misuse by, or neglect, or improper conduct of, Tenant
or Tenant’s servants, employees, agents, contractors, or licensees. 
 14.2 Floor Load-Heavy Machinery. Tenant shall not place a
load upon any floor of the Premises exceeding the floor load per square foot of area which such floor was designed to carry and which is allowed by law. Landlord reserves the right to prescribe the weight and position of all business machines and
mechanical equipment, including safes, which shall be placed so as to distribute the weight. Business machines and mechanical equipment shall be placed and maintained by Tenant at Tenant’s expense in settings sufficient in Landlord’s
judgment to absorb and prevent vibration, noise and annoyance. Tenant shall not move any safe, heavy machinery, heavy equipment, freight, bulky matter, or fixtures into or out of the Building without Landlord’s prior written consent. If such
safe, machinery, equipment, freight, bulky matter or fixtures requires special handling, Tenant agrees to employ only persons holding a Master Rigger’s License to do said work, and that all work in connection therewith shall comply with
applicable laws and regulations. Any such moving shall be at the sole risk and hazard of Tenant and Tenant will defend, indemnify and save Landlord harmless against and from any liability, loss, injury, claim or suit resulting directly or indirectly
from such moving. Proper placement of all such business machines, etc., in the Premises shall be Tenant’s responsibility. 
  

	15.	INSURANCE, INDEMNIFICATION, EXONERATION AND EXCULPATION 

 15.1 General Liability
Insurance. During the term of this Lease, Tenant shall procure, and keep in force and pay for: 
 (a) Commercial General Liability
Insurance insuring Tenant on an occurrence basis against all claims and demands for personal injury liability (including, without limitation, bodily injury, sickness, disease, and death) or damage to property which may be claimed to have occurred
from and after the time Tenant and/or its contractors enter the Premises in accordance with Article 4 of this Lease, of not less than Two Million ($2,000,000) Dollars per occurrence/ Three Million ($3,000,000) Dollars in the aggregate, in the event
of personal injury to any number of persons or damage to property, arising out of any one occurrence, and contain the “Amendment of the Pollution Exclusion” for damage caused by heat, smoke or fumes from a hostile fire. The policy shall
not contain any intra-insured exclusions as between insured persons or organizations, but shall include coverage for liability assumed under this Lease as an “insured contract” for the performance of Tenant’s indemnity obligations
under this Lease. Landlord may from time to time during the term increase the coverages required of Tenant hereunder to that customarily carried in the area in which the Premises are located on property similar to the Premises. 

(b) Workers’ Compensation in amounts required by the State in which the Building is located. 

  
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 (c) Tenant shall obtain and maintain loss of income and extra expense insurance in amounts as
will reimburse Tenant for direct or indirect loss of earnings attributable to all peril commonly insured against by prudent lessees in the business of Tenant or attributable to prevention of access to the Premises as a result of such perils. 

(d) So called “Special Form” insurance coverage for all of its contents, furniture, furnishings, equipment (including the Generator,
ANS and RODI), improvements, fixtures and personal property located at the Premises providing protection in an amount equal to one hundred percent (100%) of the replacement cost basis of said items. If this Lease is terminated as the result of
a casualty in accordance with Section 18, the proceeds of said insurance attributable to the replacement of all tenant improvements installed at the Premises by Landlord or at Landlord’s cost shall be paid to Landlord. 

(e) Any other form or forms of insurance as Tenant or Landlord or any mortgagees of Landlord may reasonably require from time to time in form,
in amounts and for insurance risks against which a prudent tenant would protect itself, and provided property owners of comparable buildings are requiring such coverage. 

During the term of this Lease Landlord shall obtain and keep in force a policy or policies of insurance covering loss or damage to the
Building (but excluding property installed by or on behalf of Tenant) caused by any peril covered under fire, extended coverage and all risk insurance in an amount of not less than ninety percent (90%) replacement cost value above the
foundation walls, as reasonably determined by Landlord from time to time. The cost of all such insurance shall be included as part of Operating Costs. 

15.2 Certificates of Insurance. Such insurance shall be effected with insurers approved by Landlord, authorized to do business in the
State wherein the Building is situated under valid and enforceable policies wherein Tenant names Landlord, Landlord’s managing agent and Landlord’s Mortgagees as additional insureds. Such insurance shall provide that it shall not be
canceled or modified without at least ten (10) days’ prior written notice to each insured named therein. On or before the time Tenant and/or its contractors enter the Premises in accordance with Articles 4 and 14 of this Lease and
thereafter not less than ten (10) days prior to the expiration date of each expiring policy, original copies of the policies provided for in Article 15.1 issued by the respective insurers, or certificates of such policies setting forth in full
the provisions thereof and issued by such insurers together with evidence satisfactory to Landlord of the payment of all premiums, for such policies, shall be delivered by Tenant to Landlord and certificates as aforesaid of such policies shall upon
request of Landlord, be delivered by Tenant to the holder of any mortgage affecting the Premises. 
 15.3 General. Tenant will save
Landlord, its agents and employees, harmless and will exonerate, defend and indemnify Landlord, its agents and employees, from and against any and all claims, liabilities or penalties asserted by or on behalf of any person, firm, corporation or
public authority arising from the Tenant’s breach of the Lease or: 
 (a) On account of or based upon any injury to person, or loss of
or damage to property, sustained, or occurring on the Premises on account of or based upon the act, omission, fault, negligence or misconduct of any person whomsoever (except to the extent the same is caused by the negligence of Landlord, its
agents, contractors or employees); 
 (b) On account of or based upon any injury to person, or loss of or damage to property, sustained or
occurring elsewhere (other than on the Premises) in or about the Building (and, in particular, without limiting the generality-’ of the foregoing, on or about the elevators, stairways, public corridors, sidewalks, concourses, arcades, malls,
galleries, vehicular tunnels, approaches, areaways, roof, or other appurtenances and facilities used in connection with the Building or Premises) arising out of the use or occupancy of the Building or Premises by the Tenant, or by any person
claiming by, through or under 

  
 27 

 
Tenant, or on account of or based upon the act, omission, fault, negligence or misconduct of Tenant, its agents, employees or contractors; 

(c) On account of or based upon (including monies due on account of) any work or thing whatsoever done (other than by Landlord or its
contractors, or agents or employees of either) on the Premises during the term of this Lease and during the period of time, if any, prior to the Term Commencement Date that Tenant may have been given access to the Premises; and 

(d) Tenant’s obligations under this Article 15.3 shall be insured either under the Commercial General Liability Insurance required under
Article 15.1, above, or by a contractual insurance rider or other coverage; and certificates of insurance in respect thereof shall be provided by Tenant to Landlord upon request. 

This Tenant indemnity and hold harmless shall include reasonable attorney’s fees incurred in connection with any such claim or
proceeding. 
 Landlord will save Tenant, its agents and employees, harmless and will exonerate, defend and indemnify Tenant, its agents and
employees, from and against any and all claims, liabilities or penalties asserted by or on behalf of any person, firm, corporation or public authority arising from the Landlord’s breach of the Lease or on account of or based upon any accident,
injury, or damage to any person or property occurring outside the Premises but within the Building or on the Complex, to the extent such, accident, injury or damage results from any negligent act or omission, or negligence on the part of Landlord,
or Landlord’s contractors, licensees, agents, servants, employees, or customers, or anyone claiming by or through Landlord; provided, however, that in no event shall Landlord be obligated under this Section 15.3 to indemnify or save
harmless Tenant, or the directors, officers, agents, employees of Tenant, to the extent such claim, expense, or liability results from any omission, fault, negligence, or other misconduct of Tenant or the officers, agents, or employees of Tenant.
This indemnity and hold harmless shall include reasonable attorney’s fees incurred in connection with any such claim or proceeding, 

15.4 Property of Tenant. In addition to and not in limitation of the foregoing. Tenant covenants and agrees that, to the maximum extent
permitted by law, all merchandise, furniture, fixtures and property of every kind, nature and description related or arising out of Tenant’s leasehold estate hereunder, which may be in or upon the Premises or Building, in the public corridors,
or on the sidewalks, areaways and approaches adjacent thereto, shall be at the sole risk and hazard of Tenant, and that if the whole or any part thereof shall be damaged, destroyed, stolen or removed from any cause or reason whatsoever, (except to
the extent the same is caused by the negligence of or willful misconduct of Landlord, its agents, contractors or employees, but subject in all events to the waiver of subrogation contained in Article 19 below), no part of said damage or loss shall
be charged to, or borne by Landlord. 
 15.5 Bursting of Pipes, etc. Landlord shall not be liable for any injury or damage to persons
or property resulting from fire, explosion, falling plaster, steam, gas, air contaminants or emissions, electricity, electrical or electronic emanations or disturbance, water, rain or snow or leaks from any part of the Building or from the pipes,
appliances, equipment or plumbing works or from the roof, street or subsurface or from any other place or caused by dampness, vandalism, malicious mischief or by any other cause of whatever nature, unless caused by or due to the negligence of
Landlord, its agents, servants or employees, and then only after (i) notice to Landlord of the condition claimed to constitute negligence and (ii) the expiration of a reasonable time after such notice has been received by Landlord without
Landlord having taken all reasonable and practicable means to cure or correct such condition; and pending such cure or correction by Landlord, Tenant shall take all reasonably prudent temporary measures and safeguards to prevent any injury, loss or
damage to persons or property. In no event shall Landlord be liable for any loss, the risk of which is covered by Tenant’s insurance or is required to be so covered by this Lease; nor shall Landlord or its agents be liable for any such damage
caused by other tenants or persons in the Building or 

  
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caused by operations in construction of any private, public, or quasi-public work; nor shall Landlord be liable for any latent defect in the Premises or in the Building. 

15.6 Repairs and Alterations-No Diminution of Rental Value. Except as otherwise provided in Article 18, there shall be no allowance to
Tenant for diminution of rental value and no liability on the part of Landlord by reason of inconvenience, annoyance or injury to Tenant arising from any repairs, alterations, additions, replacements or improvements made by Landlord, or any related
work. Tenant or others in or to any portion of the Building or Premises or any property adjoining the Building, or in or to fixtures, appurtenances, or equipment thereof, or for failure of Landlord or others to make any repairs, alterations,
additions or improvements in or to any portion of the Building, or of the Premises, or in or to the fixtures, appurtenances or equipment thereof. 
  

	16.	ASSIGNMENT, MORTGAGING AND SUBLETTING 

 16.1 Generally. 

(a) Tenant covenants and agrees that neither this Lease nor the term and estate hereby granted, nor any interest herein or therein, will be
assigned, mortgaged, pledged, encumbered, or otherwise transferred, voluntarily, by operation of law or otherwise, and that neither the Premises, nor any part thereof will be encumbered in any manner by reason of any act or omission on the part of
Tenant, or used or occupied, or permitted to be used or occupied, or utilized for desk space or for mailing privileges, by anyone other than Tenant, or for any use or purpose other than as stated in Exhibit 1, or be sublet, or offered or advertised
for subletting without, in each Instance, the express, prior written consent of Landlord, which consent shall not be unreasonably withheld, conditioned or delayed. 

(b) Without limitation, it shall not be unreasonable for Landlord to withhold such approval from any assignment or subletting where, in
Landlord’s reasonable opinion: (i) the proposed assignee or sublessee does not have a financial standing and credit rating reasonably acceptable to Landlord; (ii) the business in which the proposed assignee or sublessee is engaged
could detract from the Building, its value or the costs of ownership thereof; (iii) intentionally omitted; (iv) the proposed sublessee or assignee is a current tenant (provided Landlord has comparable space available to lease to
such current tenant) or a prospective tenant (meaning such tenant, within the past six (6) months preceding the request for an assignment or sublease) has been shown space or has been presented with or has made an offer to lease space) of the
Building; (v) the use of the premises by any sublessee or assignee (even though a Permitted Use) violates any use restriction granted by Landlord in any other lease or would otherwise cause Landlord to be in violation of its obligations under
another lease or agreement to which Landlord is a party; (vi) if such assignment or subleasing is not approved of by the holder of any mortgage on the Building (if such approval is required); (vii) a proposed assignee’s or
subtenant’s business will impose a burden on the Building’s parking facilities, elevators, common areas, facilities, or utilities that is greater than the burden imposed by Tenant, in Landlord’s reasonable judgment; (viii) any
guarantor of this Lease refuses to consent to the proposed transfer or to execute a written agreement reaffirming the guaranty; (ix) Tenant is in default of any of its obligations under the Lease at the time of the request or at the time of the
proposed assignment or sublease, each beyond any applicable, notice or cure period; (x) if requested by Landlord, the assignee or subtenant refuses to sign a commercially reasonable non-disturbance and attornment agreement in favor of
Landlord’s lender; (xi) Landlord has sued or been sued by the proposed assignee or subtenant or has otherwise been involved in a legal dispute with the proposed assignee or subtenant; (xii) intentionally omitted; (xiii) the
assignment or sublease will result in there being more than two (2) subtenants of the premises (e.g., rite assignee or subtenant intends to use the premises as an executive suite); or (xiv) the assignee or subtenant is a governmental or
quasi-governmental entity or an agency, department or instrumentality of a governmental or quasi-governmental agency. Landlord may condition its consent upon such assignee or sublessee depositing with Landlord such additional security as Landlord
may reasonably require to assure the performance and observance of the obligations of such parry to Landlord. In no event, however, shall Tenant assign this Lease or sublet the whole or any part of the premises to a proposed assignee or sublessee
which has been judicially declared bankrupt or insolvent according to law, or with 

  
 29 

 
respect to which an assignment has been made of property for the benefit of creditors, or with respect to which a receiver, guardian, conservator, trustee in involuntary bankruptcy or similar
officer has been appointed to take charge of all or any substantial part of the proposed assignee’s or sublessee’s property by a court of competent jurisdiction, or with respect to which a petition has been filed for reorganization under
any provisions of the Bankruptcy Code now or hereafter enacted, or if a proposed assignee or sublessee has filed a petition for such reorganization, or for arrangements under any provisions of the Bankruptcy Code now or hereafter enacted and
providing a plan for a debtor to settle, satisfy or extend the time for the payment of debts. 
 (c) Any request by Tenant for such consent
shall set forth or be accompanied by, in detail reasonably satisfactory to Landlord, the identification of the proposed assignee or sublessee, its financial condition and the terms on which the proposed assignment or subletting is to be made,
including, without limitation, a signed copy of all assignment and sublease documents, and clearly stating the rent or any other consideration to be paid in respect thereto; and such request shall be treated as Tenant’s warranty in respect of
the information submitted therewith. Tenant’s request shall not be deemed complete or submitted until all of the foregoing information has been received by Landlord, Landlord shall respond to such request for consent within 30 days following
Landlord’s receipt of all information, documentation and security required by Landlord with respect to such proposed sublease or assignment 

(d) The foregoing restrictions shall be binding on any assignee or sublessee to which Landlord has consented, provided, notwithstanding
anything else contained in this Lease, Landlord’s consent to any further assignment, subleasing or any sub-subleasing by any approved assignee or sublessee may be withheld by Landlord at Landlord’s
sole and absolute discretion. 
 (e) Consent by Landlord to any assignment or subleasing shall not include consent to the assignment or
transferring of any lease renewal, extension or other option, first offer, first refusal or other rights granted hereunder, or any special privileges or extra services granted to tenant by separate agreement (written or oral), or by addendum or
amendment of the Lease. 
 (f) In the case of any assignment of this Lease or subletting of the premises, the Tenant named herein shall be
and remain fully and primarily liable for the obligations of Tenant hereunder, notwithstanding such assignment or subletting, including, without limitation, the obligation to pay the Yearly Rent and other amounts provided under this Lease, and the
Tenant shall be deemed to have waived all suretyship defenses: 
 (g) In addition to the foregoing, it shall be a condition of the validity
of any such assignment or subletting that the assignee or sublessee agrees directly with Landlord, in form satisfactory to Landlord, to be bound by all the obligations of Tenant hereunder, including, without limitation, the obligation to pay Yearly
Rent and other amounts provided for under this Lease, the covenant regarding use and the covenant against further assignment and subletting. 

16.2 Reimbursement, Recapture and Excess Rent. 

(a) Tenant shall, within thirty (30) days of demand, reimburse Landlord for the reasonable fees and expenses (including legal and
administrative fees and costs), not to exceed S3,500 per request, incurred by Landlord in processing any request to assign this Lease or to sublet all or any portion of the premises, whether or not Landlord agrees thereto, and if Tenant shall fail
promptly so to reimburse Landlord, the same shall be a default in Tenant’s monetary obligations under this Lease subject to the applicable grace and cure period set forth in Article 21. 

(b) If Tenant requests Landlord’s consent to sublet all of the Premises and there are less than thirty (months) remaining on the then
existing term, Landlord shall have the option, exercisable by 

  
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written notice to Tenant given within fifteen (15) business days after Landlord’s receipt of Tenant’s completed request, to terminate this Lease as of the date specified in such
notice, which shall not be less than thirty (30) nor more than one hundred twenty (120) days after the date of such notice, as to the entire Premises in the case of a proposed assignment or subletting of the whole Premises, and as to the
portion of the Premises to be sublet in the case of a subletting of a portion. In the event of termination in respect of a portion of the Premises, the portion so eliminated shall be delivered to Landlord on the date specified in good order and
condition in the manner provided in this Lease at the end of the Term and thereafter, to the extent necessary in Landlord’s judgment, Landlord, at its own cost and expense, may have access to and may make modification to the Premises (or
portion thereof) so as to make such portion a self-contained rental unit with access to common areas, elevators and the like, Yearly Rent and the Total Rentable Area of the Premises shall be adjusted according
to the extent of the Premises for which the Lease is terminated. 
 (c) Without limitation of the rights of Landlord hereunder in respect
thereto, if there is any assignment of this Lease by Tenant for consideration or a subletting of the whole of the Premises by Tenant at a rent which exceeds the rent payable hereunder by Tenant, or if there is a subletting of a portion of the
Premises by Tenant at a rent in excess of the subleased portion’s pro rata share of the rent payable hereunder by Tenant, then Tenant shall pay to Landlord, as additional rent, forthwith upon Tenant’s receipt of, in the case of an
assignment, one-half of all of the consideration (or the cash equivalent thereof) therefor which exceeds the rent payable hereunder by Tenant and in the case of a subletting, one-half of all of any such excess rent. For the purposes of this
subsection, the term “rent” shall, mean all Yearly Rent, additional rent or other payments and/or consideration payable by one party to another for the use and occupancy of all or a portion of the Premises including, without limitation,
key money, or bonus money paid by the assignee or subtenant to Tenant in connection with such transaction and any payment in excess of fair market value for services rendered by Tenant to the assignee or subtenant or for assets, fixtures, inventory,
equipment or furniture transferred by Tenant to the assignee or subtenant in connection with any such transaction, but shall exclude any separate payments by Tenant for reasonable attorney’s fees and broker’s commissions in connection with
such assignment or subletting; any fair market free rent period or tenant improvement allowances or tenant improvements made in connection with such assignment or subletting or, in connection with a subletting, the cost of services and/or equipment
provided to or shared with such subtenant by Tenant (provided that the sublease identifies the monthly expense associated with such services and/or equipment). 

(d) If the Premises or any part thereof are sublet by Tenant, following the occurrence of a default which has continued beyond the applicable
cure period, landlord, in addition to any other remedies provided hereunder or at law, may at its option collect directly from such sublessee(s) all rents becoming due to the Tenant under such sublease(s) and apply such rent against any amounts due
Landlord by Tenant under this Lease, and Tenant hereby irrevocably authorizes and directs such sublessee(s) to so make ail such rent payments, if so directed by Landlord; and it is understood that no such election or collection or payment shall be
construed to constitute a novation of this Lease or a release of Tenant hereunder, or to create any lease or occupancy, agreement between the Landlord and such subtenant or impose any obligations on Landlord, or otherwise constitute the recognition
of such sublease by Landlord for any purpose whatsoever. 
 (e) Tenant hereby absolutely and unconditionally assigns and transfers to
Landlord all of Tenant’s interest in all rentals and income arising from any sublease entered into by Tenant, and Landlord may collect such rent, and income and apply same toward Tenant’s obligations under this Lease; provided, however,
that until a default occurs in the performance of Tenant’s obligations under this Lease, Tenant may receive, collect and enjoy the rents accruing under such sublease. Landlord shall not, by reason of this or any other assignment of such rents
to Landlord nor by reason of the collection of the rents from a subtenant, be deemed to have assumed or recognized any sublease or to be liable to the subtenant for any failure of Tenant to perform and comply with any of Tenant’s obligations to
such subtenant under such sublease, including, but not limited to, Tenant’s obligation to return any security deposit. Tenant hereby irrevocably authorizes and directs any such subtenant, upon receipt of a written notice from Landlord stating
that a default exists in the performance of Tenant’s obligations under this Lease, beyond applicable notice and cure periods, to pay to Landlord the rents due as they become due under the sublease. Tenant

  
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agrees that such subtenant shall have the right to rely upon any such statement and request from Landlord, and that such subtenant shall pay such rents to Landlord without any obligation or right
to inquire as to whether such default exists and notwithstanding any notice from or claim from Tenant to the contrary. In the event Tenant shall default in the performance of its obligations under this Lease or Landlord terminates this Lease by
reason of a default of Tenant, Landlord at its option and without any obligation to do so, may require any subtenant to attorn to Landlord, in which event Landlord shall undertake the obligations of Tenant under such sublease from the time of the
exercise of said option to the termination of such sublease; provided, however, Landlord shall not be liable for any prepaid rents or security deposit paid by such subtenant to Tenant or for any other prior defaults of Tenant under such sublease.

 16.3 Certain transfers. 

Notwithstanding any other provision of this Article 16, transactions with an entity (i) into or with which Tenant is merged or
consolidated (ii) to whom substantially all or substantially all of Tenant’s assets are transferred as a going concern or (iii) which controls or is controlled by Tenant or is under common control with Tenant shall not be deemed to be
an assignment or subletting within the meaning of this Article requiring prior consent of Landlord (such entity being hereinafter called “Assignee”, provided that in any of such events (1) Landlord receives prior written notice of any
such transactions, (2) the assignee or subtenant agrees directly with Landlord, by written instrument in form reasonably satisfactory to Landlord (Landlord agreeing to provide any comments to such-form within three (3) business days after
receipt of written notice of the transaction together with evidence that the net worth required set forth below is satisfied), to be bound by all the obligations of Tenant hereunder including, without limitation, the covenant against further
assignment and subletting, (3) in no event shall Tenant be released from its obligations under this Lease, (4) any such transfer or transaction is for a legitimate, regular business purpose of Tenant other than a transfer of Tenant’s
interest in this Lease, and (5) the involvement by Tenant or its assets in any transaction, or series of transactions (by way of merger, sale, acquisition, financing, refinancing, transfer, leveraged buy-out or otherwise) whether or not a
formal assignment or hypothecation of this Lease or Tenant’s assets occurs, will not result in a reduction of the “Net Worth” of Tenant as hereinafter defined, by an amount equal to such Net Worth of Tenant as it is represented to
Landlord at the time of the execution by Landlord of this Lease, or as it exists immediately prior to said transaction or transactions constituting such reduction, at whichever time said Net Worth of Tenant was or is greater. “Net Warm” of
Tenant for purposes of this section shall, be the net worth and liquidity of Tenant (excluding any guarantors) established under generally accepted accounting principles consistently applied. 

If Tenant is an individual who uses and/or occupies the Premises with partners, or if Tenant is a partnership, then: 

(i) Each present and future partner shall be personally bound by and upon all of the covenants, agreements, terms, provisions and conditions
set forth in this Lease on the part of Tenant to be performed; and 
 (ii) In confirmation of the foregoing, Landlord may (but without being
required to do so) request (and Tenant shall duly comply) that Tenant, at the time that Tenant admits any new partner to its partnership, shall require each such new partner to execute an agreement in form and substance satisfactory to Landlord
whereby such new partner shall agree to be personally bound by and upon all of the covenants, agreements, terms, provisions and conditions of this Lease on the part of Tenant to be performed, without regard to the time when such new partner is
admitted to partnership or when any obligations under any such covenants, etc., accrue. 
 The listing of any name other than that of
Tenant, whether on the doors of the Premises or on the Building directory, or otherwise, shall not operate to vest in any such other person, firm or corporation any right or interest in this Lease or in the Premises or be deemed to effect or
evidence any consent of Landlord, it being expressly understood that any such listing is a privilege extended by Landlord revocable at will by written notice to Tenant. 

  
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 If this Lease be assigned, or if the Premises or any part thereof be sublet or occupied by
anybody other than Tenant, Landlord may, at any time and from time to time, collect rent and other charges from the assignee, subtenant or occupant, and apply the net amount collected to the rent and other charges herein reserved then due and
thereafter becoming due, but no such assignment, subletting, occupancy or collection shall be deemed a waiver of this covenant, or the acceptance of the assignee, subtenant or occupant as a tenant, or a release of Tenant from the further performance
by Tenant of covenants on the part of Tenant herein contained. Any consent by Landlord to a particular assignment or subletting shall not in any way-diminish the prohibition stated in the first sentence of this Article 16 or the continuing liability
of the Tenant named on Exhibit 1 as the party Tenant under this Lease. No assignment or subletting shall affect the purpose for which the Premises may be used as stated in Exhibit 1. 

 

	17.	MISCELLANEOUS COVENANTS 

 Tenant covenants and agrees as follows: 

17.1 Rules and Regulations. Tenant will faithfully observe and comply with the Rules and Regulations, if any, annexed hereto and such
other and further reasonable Rules and Regulations as Landlord hereafter at any time or from time to time may make and may communicate in writing to Tenant, which in the reasonable judgment of Landlord shall be necessary for the reputation, safety,
care or appearance of the Building, or the preservation of good order therein, or the operation or maintenance of the Building, or the equipment thereof, or the comfort of tenants or others in the Building, provided, however, that in the case of any
conflict between the provisions of this Lease and any such regulations, the provisions of this Lease shall control, and provided further that nothing contained in this Lease shall be construed to impose upon Landlord any duty or obligation to
enforce the Rules and Regulations or the terms, covenants or conditions in any other lease as against any other tenant and Landlord shall not be liable to Tenant for violation of the same by any other tenant or such other tenant’s servants,
employees, agents, contractors, visitors, invitees or licensees. 
 17.2 Access to Premises-Shoring. Tenant shall: (i) permit
Landlord to erect, use and maintain pipes, ducts and conduits in and through the Premises, provided the same do not materially reduce the floor area or materially adversely affect the appearance thereof or the conduct of Tenant’s business
operations therein; (ii) upon two (2) business days’ prior written notice, which notice may be via email to the head of Tenant’s operations at the Premises (currently Jennifer Dupee - email address: jdupee@visterrarx.com)
or such successor head of operations of who Tenant notifies Landlord) (except that no notice shall be required in emergency situations), permit Landlord and any mortgagee of the Building or the Building and land or of the interest of Landlord
therein, and any lessor under any ground or underlying lease, and their representatives, to have free and unrestricted access to and to enter upon the Premises at all reasonable hours for the purposes of inspection or of making repairs, replacements
or improvements’ in or to the Premises or the Building or equipment (including, without limitation, sanitary, electrical, heating, air conditioning or other systems) or of complying with all laws, orders and requirements of governmental or
other authority or of exercising any right reserved to Landlord by this Lease (including the right during the progress of any such repairs, replacements or improvements or while performing work and furnishing materials in connection with compliance
with any such laws, orders or requirements to take upon or through, or to keep and store within, the Premises all necessary materials, tools and equipment); and (iii) permit Landlord, at reasonable times, upon reasonable prior notice to Tenant,
which may be oral, to show the Premises during ordinary business hours to any existing or prospective mortgagee, ground lessor, space lessee, purchaser, or assignee of any mortgage, of the Building or of the Building and the land or of the interest
of Landlord therein, and during the period of twelve (12) months next preceding the Termination Date to any person contemplating the leasing of the Premises or any part thereof. If, during the last month of the term, Tenant shall have removed
all or substantially all of Tenant’s property therefrom, Landlord may immediately enter and alter, renovate and redecorate the Premises, without elimination or abatement of rent, or incurring liability to Tenant for any compensation, and such
acts shall have no effect upon this Lease. If Tenant shall not be personally present to open and permit an entry into the Premises at any time when for any reason an entry therein shall be necessary or permissible, Landlord or Landlord’s agents
may enter the same by a master key, or may forcibly enter the same, without rendering Landlord or such agents liable 

  
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therefor (if during such entry Landlord or Landlord’s agents shall accord reasonable care to Tenant’s property), and without in any manner affecting the obligations and covenants of
this Lease. Provided that Landlord shall incur no additional expense thereby, Landlord shall exercise its rights of access to the Premises permitted under any of the terms and provisions of this Lease in such manner as to minimize to the extent
practicable interference with Tenant’s use and occupation of the Premises, if an excavation shall be made upon land adjacent to the Premises or shall be authorized to be made, Tenant shall upon reasonable prior notice (except that no notice
shall be required in emergency situations) afford to the person causing or authorized to cause such excavation, license to enter upon the Premises for the purpose of doing such work as said person shall deem necessary to preserve the Building from
injury or damage and to support the same by proper foundations without any claims for damages or indemnity against Landlord, or diminution or abatement of rent (except as otherwise provided in Section 8.8); provided that Landlord shall minimize
to the extent practicable interference with Tenant’s use and occupation of the Premises. 
 17.3 Accidents to Sanitary and Other
Systems. Tenant shall give to Landlord prompt notice of any fire or accident in the Premises or in the Building of which Tenant has knowledge and of any damage to, or defective condition in, any part or appurtenance of the Building of which
Tenant has knowledge including, without limitation, sanitary, electrical, ventilation, heating and air conditioning or other systems located in, or passing through, the Premises. Except as otherwise provided in Articles 18 and 20, and subject to
Tenant’s obligations in Article 14, such damage or defective condition shall be remedied by Landlord with reasonable diligence, but if such damage or defective condition was caused by Tenant or by the employees, licensees, contractors or
invitees of Tenant, the cost to remedy the same shall be paid by Tenant. In addition, all reasonable costs incurred by Landlord in connection with the investigation of any notice given by Tenant shall be paid by Tenant if the reported damage or
defective condition was caused by Tenant or by the employees, licensees, contractors, or invitees of Tenant. Tenant shall not be entitled to claim any eviction from the Premises or any damages arising from any such damage or defect unless the same
(i) shall have been occasioned by the gross negligence of the Landlord, its agents, servants or employees and (ii) shall not, after notice to Landlord of the condition claimed to constitute negligence, have been cured or corrected within a
reasonable time after such notice has been received by Landlord; and in case of a claim of eviction unless such damage or defective condition shall have rendered the Premises untenantable and they shall not have been made tenantable by Landlord
within a reasonable time. 
 17.4 Signs, Blinds and Drapes. Tenant shall put no signs In any part of the Building. No signs or blinds
may be put on or in any window or elsewhere if visible from the exterior of the Building, nor may the building standard drapes or blinds be removed by Tenant. Notwithstanding the foregoing. Landlord shall provide, at its own cost, Building standard
signage on all tenant directories within the Complex which include the three (3) exterior kiosk signs located at the pedestrian level entries to the Complex as well as the Garage lobby level and elevator lobby directory signage. Tenant may hang
its own drapes, provided that they shall not in any way interfere with the building standard drapery or blinds or be visible from the exterior of the Building and that such drapes are so hung and installed that when drawn, the building standard
drapery or blinds are automatically also drawn. Tenant may install, at its sole cost, signage at Tenant’s entrance to the Premises upon Landlord’s prior written approval, not to be unreasonably withheld. Any signs or lettering in the
public corridors or on the doors shall conform to Landlord’s building standard design. Neither Landlord’s name, nor the name of the Building or Complex of which the Building is a part, or the name of any other structure erected therein
shall be used without Landlord’s consent in any advertising material (except on business stationery or as an address in advertising matter), nor shall any such name, as aforesaid, be used in any undignified, confusing, detrimental or misleading
manner. 
 17.5 Estoppel Certificate and Financial Statements. Tenant shall at any time and from time to time upon not less than ten
(10) days’ prior notice by Landlord to Tenant, execute, acknowledge and deliver to Landlord a statement in writing certifying that this Lease is unmodified and in full force and effect (or if there have been modifications, that the same is
in full force and effect as modified and stating the modifications), and the dates to which the Yearly Rent and other charges have been paid in advance, if any, stating whether or not to Tenant’s knowledge Landlord is in default in performance
of any covenant, agreement, term, provision, or condition contained in this Lease and, if so, specifying each such default and such other facts as Landlord may reasonably request, it being intended that any such statement delivered

  
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 pursuant hereto may be relied upon by any prospective purchaser of the Building or of the Building and the land
or of any interest of Landlord therein, any mortgagee or prospective mortgagee thereof, any lessor or prospective lessor thereof, any lessee or prospective lessee thereof, or any prospective assignee of any mortgage thereof. Time is of the essence
in respect of any such requested certificate, Tenant hereby acknowledging the importance of such certificates in mortgage financing arrangements, prospective sale and the like. In the event Tenant fails to execute and deliver such statement to
Landlord within such ten (10) day period, then Landlord may send a second request to Tenant, in writing, and Tenant shall respond within five (5) days or the Lease shall be deemed to be in full force and effect and the facts contained in
such statement shall be deemed true, accurate and complete. Within 120 days after the end of Tenant’s fiscal years during the term of this Lease, Tenant agrees to furnish to Landlord copies of Tenant’s most recent annual, quarterly and
monthly financial statements, audited if available (if such audited financial statement is not available, such financial statement may be certified by an officer (vice president or higher) of Tenant). The financial statements shall be prepared in
accordance with generally accepted accounting principles, consistently applied. The financial statements shall include a balance sheet and a statement of profit and loss, and the annual financial statement shall also include a statement of changes
in financial position and appropriate explanatory notes. Landlord will maintain the confidentiality of such financial statements but may deliver the financial statements to any prospective or existing mortgagee or purchaser of the Building and/or
Complex who is under an obligation to keep same confidential. 
 17.6 Prohibited Materials and Property. Tenant shall not bring or
permit to be brought or kept in or on the Premises or elsewhere in the Building (i) except in compliance with Section 29.11, any inflammable, combustible or explosive fluid, material, chemical or substance including, without limitation,
any hazardous substances as defined under Massachusetts General Laws chapter 21E, the Federal Comprehensive Environmental Response Compensation and Liability Act (CERCLA), 42 USC §9601 et seq., amended, under
Section 3001 of the Federal Resource Conservation and Recovery Act of 1,976, as amended, or under any regulation of any governmental authority regulating environmental or health, matters (except for standard office supplies stored in proper
containers), (ii) any materials, appliances or equipment (including, without limitation, materials, appliances and equipment selected by Tenant for the construction or other preparation of the Premises and furniture and carpeting) which pose
any danger to life, safety or health or may cause damage, injury or death; (iii) any unique, unusually valuable, rare or exotic property, work of art or the like unless the same is fully insured under all-risk coverage, or (iv) any data
processing, electronic, optical or other equipment or property of a delicate, fragile or vulnerable nature unless the same are housed, shielded and protected against harm and damage, whether by cleaning or maintenance personnel, radiations
or-emanations from other equipment now or hereafter installed in the Building, or otherwise. Nor shall Tenant cause or permit any potentially harmful air emissions, odors of cooking or other processes, or any unusual or other objectionable odors or
emissions to emanate from or permeate the Premises. 
 17.7 Requirements of Law-Fines and Penalties. Tenant at its sole expense shall
comply with all laws, rules, orders and regulations, including, without limitation, all energy-related requirements, of Federal, State, County and Municipal Authorities and with any direction of any public officer or officers, pursuant to law, which
shall impose any duty upon Landlord or Tenant with respect to or arising out of Tenant’s use or occupancy of the Premises. Tenant shall reimburse and compensate Landlord for ail expenditures made by, or damages or fines sustained or incurred
by, Landlord due to nonperformance or noncompliance with or breach or failure to observe any item, covenant, or condition of this Lease upon Tenant’s part to be kept, observed, performed or complied with. If Tenant receives notice of any
violation of law, ordinance, order or regulation applicable to the Premises, it shall give prompt notice thereof to Landlord. 
 17.8
Tenant’s Acts—Effect on Insurance. Tenant shall not do or permit to be done any act or thing upon the Premises or elsewhere in the Building which will invalidate or be in conflict with any insurance policies covering the Building and
the fixtures and property therein; and shall not do, or permit to be done, any act or thing upon the Premises which shall subject Landlord to any liability or responsibility for injury to any person or persons or to property by reason of any
business or operation being carried on upon said Premises or for any other reason. Tenant at its own expense shall comply with all rules, orders, 

  
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 regulations and requirements of the Board of Fire Underwriters, or any other similar body having jurisdiction,
and shall not (i) do, or permit anything to be done, in or upon the Premises, or bring or keep anything therein, except as now or hereafter permitted by the Fire Department, Board of Underwriters, Fire Insurance Rating Organization, or other
authority having jurisdiction, and then only in such quantity and manner of storage as will not increase the rate for any insurance applicable to the Building, or (ii) use the Premises in a manner which shall increase such insurance rates on
the Building, or on property located therein, over that applicable when Tenant first took occupancy of the Premises hereunder. If by reason of the failure of Tenant to comply with the provisions hereof the insurance rate applicable to any policy of
insurance shall at any time thereafter be higher than it otherwise would be the Tenant shall reimburse Landlord for that part of any insurance premiums thereafter paid by Landlord, which shall have been charged because of such failure by Tenant.

 17.9 Miscellaneous. Tenant shall not suffer or permit the Premises or any fixtures, equipment or utilities therein or serving the
same, to be overloaded, damaged or defaced, nor permit any hole to be drilled or made in any part thereof. Tenant shall not suffer or permit any employee, contractor, business invitee or visitor to violate any covenant, agreement or obligations of
the Tenant under this Lease. 
  

	18.	DAMAGE BY FIRE, ETC. 

 (a) If the Premises or the Building are damaged in whole or in
part by any fire or other casualty (a “casualty”), and Tenant has actual knowledge thereof (it being agreed that Tenant shall be deemed to have actual knowledge of any damage within the Premises), the Tenant shall immediately give notice
thereof to the Landlord. Unless this Lease is terminated as provided herein, the Landlord, at its own expense (except for any insurance deductibles, which shall be deemed Operating Costs),, and proceeding with due diligence and all reasonable
dispatch, but subject to delays beyond the reasonable control of Landlord, shall repair and reconstruct the same so as to restore the Premises (but not any alterations or additions made by or for Tenant or any trade fixtures, equipment or personal
property of Tenant, except for Tenant’s Improvements) to substantially the same condition, they were in prior to the casualty, subject to zoning, building and other laws then in effect. Notwithstanding the foregoing, in no event shall Landlord
be obligated either to repair or rebuild if the damage or destruction results from an uninsured casualty or if the costs of such repairing, or rebuilding exceeds the amount of the insurance proceeds (net of all costs and expenses incurred, in
obtaining same) received by Landlord on account thereof, Landlord shall not be liable for any Inconvenience or annoyance to Tenant or injury to the business of Tenant resulting from delays in repairing such damage. 

(b) Landlord shall, within forty-five (45) days after the occurrence of a casualty, provide Tenant with a good faith estimate of the time
required to repair the damage to the Premises or the Building, as provided herein; if such estimate is for a period of more than two hundred seventy (270) days from the occurrence of the casualty (or during the last eighteen (18) months of
the term, for a period of more than ninety (90) days), the Premises shall be deemed “substantially damaged”. If the Premises or the Building are substantially damaged, Landlord may elect to terminate this Lease by giving Tenant
written, notice of such termination within sixty (60) days of the date of such casualty; and if the Premises or the Building are substantially damaged, and if as a result the Premises are rendered completely untenantable or inaccessible for the
uses permitted under this Lease, then Tenant may terminate this Lease by giving Landlord written notice of such termination within sixty (60) days of the date of such casualty. 

(c) For so long as such damage results in material interference with the operation of Tenant’s use of the Premises which material
interference causes Tenant to be unable to use the Premises, the Yearly Rent and additional rent payable by Tenant shall abate or be reduced proportionately for the period, commencing on the day following such material interference and continuing
until the Premises has been substantially restored. Notwithstanding the foregoing, if such casualty was due to the negligence or willful misconduct of Tenant or Tenant’s employees, contractors, invitees or agents, such abatement or reduction
shall be made only if and to the extent of any proceeds of rental interruption insurance actually received by Landlord and allocated to the Premises. 

  
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 (d) If the Premises are damaged by a casualty, and the Lease is not terminated as provided
herein, the Tenant, at its own expense, and proceeding with an reasonable dispatch, shall repair and reconstruct all of the improvements, alterations and additions made to the Premises by or for Tenant, including and any trade fixtures, equipment or
personal property of Tenant which shall have been damaged or destroyed (other than Tenant’s Improvements). 
 Any dispute between the
parties relating to the provisions or obligations in this Article 18 shall be submitted to arbitration pursuant to Article 29.5 hereof. 
  

	19.	WAIVER OF SUBROGATION 

 In any case in which Tenant shall be obligated to pay to Landlord
any loss, cost, damage, liability, or expense suffered or incurred by Landlord, Landlord shall allow to Tenant as an offset against the amount thereof (i) the net proceeds of any insurance collected by Landlord for or on account of such loss,
cost, damage, liability or expense, provided that the allowance of such offset does not invalidate or prejudice the policy or policies under which such proceeds were payable, and (ii) if such loss, cost, damage, liability or expense shall have
been caused by a peril against which Landlord has agreed to procure insurance coverage under the terms of this Lease, the amount of such insurance coverage, whether or not actually procured by Landlord. 

In any case in which Landlord or Landlord’s managing agent shall be obligated to pay to Tenant any loss, cost, damage, liability or
expense suffered or incurred by Tenant, Tenant shall allow to Landlord or Landlord’s managing agent, as the case may be, as an offset against the amount thereof (i) the net proceeds of any insurance collected by Tenant for or on account of
such loss, cost, damage, liability, or expense, provided that the allowance of such offset does not invalidate the policy or policies under which such proceeds were payable and (ii) the amount of any loss, cost, damage, liability or expense
caused by a peril against which Tenant has agreed to procure insurance coverage under the terms of this Lease, the amount of such insurance coverage, whether or not actually procured by Tenant, 

The parties hereto shall each procure an appropriate clause in, or endorsement on, any property insurance policy covering the Premises and the
Building and personal property, fixtures and equipment located thereon and therein, pursuant to which the insurance companies waive subrogation or consent to a waiver of right of recovery in favor of either party, its respective agents or employees.
Having obtained such clauses and/or endorsements, each party hereby agrees that it will not make any claim against or seek to recover from the other or its agents or employees for any loss or damage to its property or the property of others
resulting from fire or other perils covered by such property insurance. 
  

	20.	CONDEMNATION-EMINENT DOMAIN 

 (a) In the event of any condemnation or taking in any
manner for public or quasi-public use, which shall be deemed to include a voluntary conveyance in lieu of a taking (a “taking”) of the whole of the Building, this Lease shall forthwith terminate as of the date when Tenant is required to
vacate the Premises. 
 (b) Unless this Lease is terminated as provided herein, the Landlord, at its own expense, and proceeding with due
diligence and all reasonable dispatch, but subject to delays beyond the reasonable control of Landlord, shall restore the remaining portion of the Premises (but not any alterations or improvements made by or for Tenant, but including Tenant’s
Improvements, or any trade fixtures, equipment or personal property of Tenant) and the necessary portions of the Building as nearly as practicable to the same condition as it was prior to such taking, subject to zoning and building laws then in
effect Notwithstanding the foregoing, Landlord’s obligation to restore the remaining portion of the Premises shall be limited to the extent of the condemnation, proceeds (net of all costs and expenses incurred in connection with same) received
by Landlord on account thereof. Landlord shall not be liable for any inconvenience or annoyance to Tenant or injury to the business of Tenant resulting from delays in restoring the Premises. 

  
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 (c) In the event that only a part of the Premises or the Building shall be taken, then, if such
taking is a substantial taking (as hereinafter defined), either Landlord or Tenant may by delivery of notice in writing to the other within sixty (60) days following the date on which Landlord’s title has been divested by such authority,
terminate this Lease, effective as of the date when Tenant is required to vacate any portion of the Premises or appurtenant rights. A “substantial taking” shall mean a taking which: requires restoration and repair of the remaining portion
of the Building that cannot in the ordinary course be reasonably expected to be repaired within one hundred eighty (180) days; results in the loss of reasonable access to the Premises; or results in the loss of more than twenty-five percent
(25%) of the rentable floor area of the Premises. 
 (d) If this Lease is not terminated as aforesaid, then this Lease shall continue
in full force and effect, provided if as a result of which there is material interference with the operation of Tenant’s use of the Premises, then the Yearly Rent and additional rent payable by Tenant shall be justly and equitably abated and
reduced according to the nature and extent of the loss of use thereof suffered by Tenant, 
 (e) Landlord shall have and hereby reserves and
excepts, and Tenant hereby grants and assigns to Landlord, all lights to recover for damages to the Building, the Complex, and the leasehold interest hereby created (including any award made for the value of the estate vested by this Lease in
Tenant), and to compensation accrued or hereafter to accrue by reason of such taking, and by way of confirming the foregoing, Tenant hereby grants and assigns, and covenants with Landlord to grant and assign, to Landlord all rights to such damages
of compensation. Nothing contained herein shall be construed to prevent Tenant from prosecuting in any condemnation proceedings a separate claim for the value of any of Tenant’s personal property and for relocation expenses and business losses,
provided that such action shall not affect the amount of compensation otherwise recoverable by Landlord from the taking authority. 
 Any
dispute between the parties relating to the provisions or obligations in this Article 20 shall be submitted to arbitration pursuant to Article 29,5 hereof. 
  

	21.	DEFAULT 

 21.1 Conditions of Limitation Re-Entry-Termination. This Lease and the
herein term and estate are, upon the condition that if (a) subject to Article 21.7, Tenant shall neglect or fail to perform or observe any of the Tenant’s covenants or agreements herein, including (without limitation) the covenants or
agreements with regard to the payment when due of rent, additional charges, reimbursement for increase in Landlord’s costs, or any other charge payable by Tenant to Landlord (all of which shall be considered as part of Yearly Rent for the
purposes of invoking Landlord’s statutory or other rights and remedies in respect of payment defaults); or (b) intentionally omitted; or (c) Tenant shall be involved in financial difficulties as evidenced by an admission in writing by
Tenant of Tenant’s inability to pay its debts generally as they become due, or by the making or offering to make a composition of its debts with its creditors;, or (d) Tenant shall make an assignment or trust mortgage, or other conveyance
, or transfer of like nature , of all or a substantial part of its property for the benefit of its creditors, or (e) an attachment on mesne process, on execution or otherwise, or other legal process shall issue against Tenant or its property
and a sale of any of its assets shall be held thereunder; or (f) any judgment, final beyond appeal or any lien, attachment or the like shall be entered, recorded or filed against Tenant in any court, registry, etc. and Tenant shall fail to pay
such judgment within forty-five (45) days after the judgment shall have become final beyond appeal or to discharge or secure by surety bond such lien, attachment, etc. within forty-five (45) days of such entry, recording or filing, as the
case may be; or (g) the leasehold hereby created shall be taken on execution or by other process of law and shall not be revested in Tenant within forty-five (45) days thereafter; or (h) a receiver, sequesterer, trustee or similar
officer shall be appointed by a court of competent jurisdiction to take charge of all or any part of Tenant’s property and such appointment shall not be vacated within forty five (45) days; or (i) any proceeding shall be instituted by
or against Tenant pursuant to any of the provisions of any Act of Congress or State law relating to bankruptcy, reorganizations, arrangements, compositions or other relief from creditors, and, in the case of any proceeding instituted against it, if
Tenant 

  
 38 

 shall fail to have such proceedings dismissed within forty-five (45) days or if Tenant is adjudged bankrupt
or insolvent as a result of any such proceeding, or (j) any event shall occur or any contingency shall arise whereby this Lease, or the term and estate thereby created, would (by operation of law or otherwise) devolve upon or pass to any
person, firm or corporation other than Tenant, except as expressly permitted under Article 16 hereof - then, and in any such event Landlord may, by notice to Tenant, elect to terminate this Lease; and thereupon (and without prejudice to any remedies
which might otherwise be available for arrears of rent or other charges due hereunder or preceding breach of covenant or agreement and without prejudice to Tenant’s liability for damages as hereinafter stated), upon the giving of such notice,
this Lease shall terminate as of the date specified therein as though that were the Termination Date as stated in Section 3.2. Without being taken or deemed to be guilty of any manner of trespass or conversion, and without being liable to
indictment, prosecution or damages therefor, Landlord may, forcibly if necessary, enter into and upon the Premises (or any part thereof in the name of the whole); repossess the same as of its former estate; and expel Tenant and those claiming under
Tenant. Wherever “Tenant” is used in subdivisions (c), (d), (e), (f), (g), (h) and (i) of this Article 21.1, it shall be deemed to include any one of (i) any corporation of which Tenant is a controlled subsidiary and
(ii) any guarantor of any of Tenant’s obligations under this Lease. The words “re-entry” and “re-enter” as used in this Lease are not restricted to their technical legal meanings. 

21.2 Intentionally Omitted. 

21.3 Damages-Termination. Upon the termination of this Lease under the provisions of this Article 21, Tenant shall pay to Landlord the
rent and other charges payable by Tenant to Landlord up to the time of such termination, shall continue to be liable for any preceding breach of covenant, and in addition, shall pay to Landlord as damages, at the election of Landlord 

either: 
 (x) the amount by
which, at the time of the termination of this Lease (or at any time thereafter if Landlord shall have initially elected damages under subparagraph (y), below), (i) the aggregate of the rent and other charges projected over the period commencing
with such termination and ending on the Termination Date as stated in Exhibit 1 exceeds (ii) the aggregate projected fair market rental value of the Premises for such period; 

or: 
 (y) amounts equal to the
rent and other charges which would have been payable by Tenant had this Lease not been so terminated, payable upon the due dates therefor specified herein following such termination and until the Termination Date as specified in Exhibit 1, provided,
however, if Landlord shall re-let the Premises during such period, that Landlord shall credit Tenant with the net rents received by Landlord from such re-letting, such net rents to be determined by first deducting from the gross rents as and when
received by Landlord from, such re-letting the expenses incurred or paid by Landlord in terminating this Lease, as well as the expenses of re-letting, including altering and preparing the Premises for new tenants, brokers’ commissions, and all
other similar and dissimilar expenses properly chargeable against the Premises and the rental therefrom, it being understood that any such re-letting may be for a period equal to or shorter or longer than the remaining term of this Lease; and
provided, further, that (i) in no event shall Tenant be entitled to receive any excess of such net rents over the sums payable by Tenant to Landlord hereunder and (ii) in no event shall Tenant be entitled in any suit for the collection of
damages pursuant to this Subparagraph (y) to a credit in respect of any net rents from a re-letting except to the extent that such net rents are actually received by Landlord prior to the commencement of such suit. If the Premises or any part
thereof should be re-let in combination with other space, then proper apportionment on a square foot area basis shall be made of the rent received from such re-letting and of the expenses of reletting. 

  
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 In calculating the rent and other charges under Subparagraph (x), above, there shall be included,
in addition to the Yearly Rent, Tax Share and Operating Expense Share and all other considerations agreed to be paid or performed by Tenant, on the assumption that all such amounts and considerations would have remained constant (except as herein
otherwise provided) for the balance of the full term hereby granted. 
 Suit or suits for the recovery of such damages, or any installments
thereof, may be brought by Landlord from time to time at its election, and nothing contained herein shall be deemed to require Landlord to postpone suit until the date when the term of this Lease would have expired if it had not been terminated
hereunder. 
 Nothing herein contained shall be construed as limiting or precluding the recovery by Landlord against Tenant of any sums or
damages to which, in addition to the damages particularly provided above, Landlord may lawfully be entitled by reason of any default hereunder on the part of Tenant. Notwithstanding anything to the contrary, Landlord shall be entitled to recover, in
addition to the rent and other charges under Subparagraph (x) or (y) above, any other amount necessary to compensate Landlord for all detriment proximately caused by Tenant’s failure to perform its obligations under the Lease or which
in the ordinary course of things would be likely to result therefrom, including, but not limited to, the cost of recovering possession of the Premises, reasonable attorneys’ fees, any real estate commissions actually paid by Landlord and the
unamortized value of any free rent, reduced rent, tenant improvement allowance or other economic concessions provided by Landlord. 

21.4 Fees and Expenses. 

(a) If Tenant shall default in the performance of any covenant on Tenant’s part to be performed as in this Lease contained, Landlord may
immediately, or at any time thereafter, without notice, perform the same for the account of Tenant. If Landlord at any time is compelled to pay or elects to pay any sum of money, or do any act which will require the payment of any sum of money, by
reason of the failure of Tenant to comply with any provision hereof, or if Landlord is compelled to or does incur any expense, including reasonable attorneys’ fees, in instituting, prosecuting, and/or defending any action or proceeding
instituted by reason of any default of Tenant hereunder, Tenant shall on demand pay to Landlord by way of reimbursement the sum or sums so paid by Landlord with all costs and damages, plus interest computed as provided in Article 6 hereof. 

(b) Tenant shall pay Landlord’s cost and expense, including reasonable attorneys’ fees, incurred (i) in enforcing any
obligation of Tenant under this Lease or (ii) as a result of Landlord, without its fault, being made party to any litigation pending by or against Tenant or any persons claiming through or under Tenant. 

21.5 Waiver of Redemption. Tenant does hereby waive and surrender all rights and privileges which it might have under or by reason of
any present or future law to redeem the Premises or to have a continuance of this Lease for the term hereby demised after being dispossessed or ejected therefrom by process of law or under the terms of this Lease or after the termination of this
Lease as herein provided. 
 21.6 Landlord’s Remedies Not Exclusive. The specified remedies to which Landlord may resort
hereunder are cumulative and are not intended to be exclusive of any remedies or means of redress to which Landlord may at any time be lawfully entitled, and Landlord may invoke any remedy (including the remedy of specific performance) allowed at
law or in equity as if specific remedies were not herein provided for. 
 21.7 Grace Period. Notwithstanding anything to the contrary
in this Article contained, Landlord agrees not to take any action to terminate this Lease (a) for default by Tenant in the payment when due of any sum of money, if Tenant shall cure such default within five (5) days after written notice
thereof is given by Landlord to Tenant, provided, however, that no such notice need be given if on two (2) prior occasions had been a default in the payment of money which had been cured after notice thereof had been 

  
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 given by Landlord to Tenant as herein provided or (b) for default by Tenant in the performance of any
covenant other than a covenant to pay a sum of money, if Tenant shall cure such default within a period of thirty (30) days after written notice thereof given by Landlord to Tenant (the “Non-Monetary Grace Period”) (except where the
nature of the default is such that remedial action in Landlord’s reasonable judgment should appropriately take place sooner, as indicated in such written notice), or within such additional period as may reasonably be required to cure such
default if (because of governmental restrictions or any other cause beyond the reasonable control of Tenant) the default is of such a nature that it cannot be cured within such thirty (30) day period, provided, however, (1) that there
shall be no extension of time beyond such thirty (30) day period for the curing of any such default unless, not more than ten (10) days after the receipt of the notice of default, Tenant in writing (i) shall specify the cause on
account of which the default cannot be cured during such period and shall advise Landlord of its intention duly to institute all steps necessary to cure the default and (ii) shall, as soon as reasonably practicable, duly institute and
thereafter diligently prosecute to completion all steps necessary to cure such default and, (2) that no notice of the opportunity to cure a default need be given, and no grace period whatsoever shall be allowed to Tenant, if the default is
incurable or if the covenant or condition the breach of which gave rise to default had, by reason of a breach on a prior occasion, been, the subject of a notice given hereunder within the then-preceding twelve (12) months to cure such default.
Notwithstanding the foregoing, Tenant shall have no right to notice or the Non-Monetary Grace Period relating to its failure to (v) maintain all insurance as required in Article 15 above; (w) deliver to Landlord the Security Deposit as
required by Section 29.13 below: (x) provide Landlord with Estoppel Certificates as required pursuant to Section 17.5 above after a second notice from Landlord requesting same; (y) provide Landlord with subordination agreements
as required pursuant to Article 23 below; or (z) provide Landlord with the certificates of insurance required pursuant to Article 15 above. 

Notwithstanding anything to the contrary in this Article 21.7 contained, except to the extent prohibited by applicable law, any statutory
notice and grace periods provided to Tenant by law are hereby expressly waived by Tenant. 
  

	22.	END OF TERM-ABANDONED PROPERTY 

 Upon the expiration or other termination of the term, of
this Lease, Tenant shall peaceably quit and surrender to Landlord the Premises and all alterations and additions thereto, broom clean, in good order, repair and condition (except as provided herein and in Articles 8.7, 18 and 20) excepting only
ordinary wear and use (as defined in Article 14.1 hereof) and damage by fire or other casualty for which, under other provisions of this Lease, Tenant has no responsibility of repair or restoration. Tenant shall remove all of its property,
including, without limitation, all telecommunication, computer and other cabling installed by Tenant in the Premises or elsewhere in the Building, and, to the extent specified by Landlord, all alterations and additions made by Tenant and all
partitions made by Tenant wholly within the Premises, and shall repair any damages to the Premises or the Building caused by their installation or by such removal. Tenant’s obligation to observe or perform this covenant shall survive the
expiration or other termination of the term of this Lease. 
 Tenant will remove any personal property from the Building and the Premises
upon or prior to the expiration or termination of this Lease and any such property which shall remain in the Building or the Premises thereafter shall be conclusively deemed to have been abandoned, and may either be retained by Landlord as its
property or sold or otherwise disposed of in such manner as Landlord may see fit. If any part thereof shall be sold, Landlord may receive and retain the proceeds of such sale and apply the same, at its option, against the expenses of the sale, the
cost of moving and storage, any arrears of Yearly Rent, additional or other charges payable hereunder by Tenant to Landlord and any damages to which Landlord may be entitled under Article 21 hereof or pursuant to law. 

If Tenant or anyone claiming under Tenant shall remain in possession of the Premises or any part thereof after the expiration or prior
termination of the term of this Lease without any agreement in writing between Landlord and Tenant with respect thereto, then, prior to the acceptance of any payments for rent or use and occupancy by Landlord, the person remaining in possession
shall be deemed a tenant-at-sufferance. 

  
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 Whereas the parties hereby acknowledge that Landlord may need the Premises after the expiration or prior
termination of the term of the Lease for other tenants and that the damages which Landlord may suffer as the result of Tenant’s holding-over cannot be determined as of the Execution Date hereof, in the event that Tenant so holds over, Tenant
shall, pay to Landlord in addition to all rental and other charges due and accrued under the Lease prior to the date of termination, charges (based upon fair market rental value of the Premises) for use and occupation of the Premises thereafter and,
in addition to such sums and any and all other rights and remedies which Landlord may have at law or in equity, an additional use and occupancy charge in the amount of fifty percent (50%) of either the Yearly Rent and other charges calculated
(on a daily basis) at the highest rate payable under the terms of this Lease, but measured from the day on which Tenant’s hold-over commenced and terminating on the day on which Tenant vacates the Premises or the fair market value of the
Premises for such period, whichever is greater. In addition, if any such holdover exceeds thirty (30) days, Tenant shall save Landlord, its agents and employees, harmless and will exonerate, defend and indemnify Landlord, its agents and
employees, from and against any and all damages which Landlord may suffer on account of Tenant’s hold-over in the Premises after the expiration or prior termination of the term of the Lease. 

 

	23.	SUBORDINATION 

 (a) Subject to any mortgagee’s or ground lessor’s election, as
hereinafter provided for, this Lease is subject and subordinate in all respects to all matters of record (including, without limitation, deeds and land disposition agreements), ground leases and/or underlying leases, and all mortgages, any of which
may now or hereafter be placed on or affect such leases and/or the real property of which the Premises are a part, or any part of such real property, and/or Landlord’s interest or estate therein, and to each advance made and/or hereafter to be
made under any such mortgages, and to all renewals, modifications, consolidations, replacements and extensions thereof and all substitutions therefor. This Article 23 shall be self-operative and no further instrument or subordination shall be
required. In confirmation of such subordination, Tenant shall execute, acknowledge and deliver promptly any certificate or instrument that Landlord and/or any mortgagee and/or lessor under any ground or underlying lease and/or their respective
successors in interest may request, subject to Landlord’s, mortgagee’s and ground lessor’s right to do so for, on behalf and in the name of Tenant under certain circumstances, as hereinafter provided. Tenant acknowledges that, where
applicable, any consent or approval hereafter given by Landlord may be subject to the further consent or approval of such mortgagee and/or ground lessor; and the failure or refusal of such mortgagee and/or ground lessor to give such consent or
approval shall, notwithstanding anything to the contrary in this Lease contained, constitute reasonable justification for Landlord’s withholding its consent or approval. 

(b) Any such mortgagee or ground lessor may from time to time subordinate or revoke any such subordination of the mortgage or ground lease
held by it to this Lease. Such subordination or revocation, as the case may be, shall be effected by written notice to Tenant and by recording an instrument of subordination or of such revocation, as the case may be, with the appropriate registry of
deeds or land records and to be effective without any further act or deed on the part of Tenant. In confirmation of such subordination or of such revocation, as the case may be, Tenant shall execute, acknowledge and promptly deliver any certificate
or instrument that Landlord, any mortgagee or ground lessor may request, subject to Landlord’s, mortgagee’s and ground lessor’s right to do so for, on behalf and in the name of Tenant under certain circumstances, as hereinafter
provided. 
 (c) Without limitation of any of the provisions of this Lease, if any ground lessor or mortgagee shall succeed to the interest
of Landlord by reason of the exercise of its rights under such ground lease or mortgage (or the acceptance of voluntary conveyance in lieu thereof) or any third party (including, without limitation, any foreclosure purchaser or mortgage receiver)
shall succeed to such interest by reason of any such exercise or the expiration or sooner termination of such ground lease, however caused, then such successor may, upon notice and request to Tenant (which, in the case of a ground lease, shall be
within thirty (30) days after such expiration or sooner termination), succeed to the interest of Landlord under this Lease, provided, however, that such successor shall not: (i) be liable for any previous act or omission of Landlord under
this Lease; (ii) be subject to any offset, defense, or counterclaim which shall theretofore 

  
 42 

 
have accrued to Tenant against Landlord; (iii) have any obligation with respect to any security deposit unless it shall have been paid over or physically delivered to such successor: or
(iv) be bound by any previous modification of this Lease or by any previous payment of Yearly Rent for a period greater than one (1) month, made without such ground lessors or mortgagee’s consent where such consent is required by
applicable ground lease or mortgage documents. In the event of such succession to the interest of the Landlord - and notwithstanding that any such mortgage or ground lease may antedate this Lease - the Tenant shall attorn to such successor and
shall, ipso facto be and become bound directly to such successor in interest to Landlord to perform and observe all the Tenant’s obligations under this Lease without the necessity of the execution of any further instrument. Nevertheless, Tenant
agrees at any time and from time to time during the term hereof to execute a suitable instrument in confirmation of Tenant’s agreement to attorn, as aforesaid, subject to Landlord’s, mortgagee’s and ground lessor’s right to do so
for, on behalf and in the name of Tenant under certain circumstances, as hereinafter provided. 
 (d) The term “mortgage(s)” as
used in this Lease shall include any mortgage or deed of trust. The term, “mortgagee(s)” as used in this Lease shall include any mortgagee or any trustee and beneficiary under a deed of trust or receiver appointed under a mortgage or deed
of trust. The term “mortgagor(s)” as used in this Lease shall include any mortgagor or any grantor under a deed of trust. 
 (e)
Notwithstanding anything to the contrary contained in this Article 23, if all or part of Landlord’s estate and interest in the real property of which the Premises are a part shall be a leasehold estate held under a ground lease, then:
(i) the foregoing subordination provisions of this Article 23 shall not apply to any mortgages of the fee interest in said real property to which Landlord’s leasehold estate is not otherwise subject and subordinate; and (ii) the
provisions of this Article 23 shall in no way waive, abrogate or otherwise affect any agreement by any ground lessor (x) not to terminate this Lease incident to any termination of such ground lease, prior to its term expiring or (y) not to
name or join Tenant in any action or proceeding by such ground lessor to recover possession of such real property or for any other relief. 

(f) In the event of any failure by Landlord to perform, fulfill or observe any agreement by Landlord herein, in no event will the Landlord be
deemed to be in default under this Lease permitting Tenant to exercise any or all rights or remedies under this Lease until the Tenant shall have given written notice of such failure to any mortgagee (ground lessor and/or trustee) of which Tenant
shall have been advised and until a reasonable period of time shall have elapsed following the giving of such notice, during which such mortgagee (ground lessor and/or trustee) shall have the right, but shall not be obligated, to remedy such
failure. 
 (g) Landlord agrees to request a subordination, non-disturbance and attornment agreement from the Landlord’s current
mortgagee, in a commercially reasonable form that is mutually acceptable to Tenant, Landlord and such Landlord’s mortgagee. 
  

	24.	QUIET ENJOYMENT 

 Landlord covenants that if, and so long as, Tenant keeps and performs
each and every covenant, agreement, term, provision and condition herein contained on the part and on behalf of Tenant to be kept and performed, Tenant shall quietly enjoy the Premises from and against the claims of all persons claiming by, through
or under Landlord subject, nevertheless, to the covenants, agreements, terms, provisions and conditions of this Lease and to the mortgages, ground leases and/or underlying leases to which this Lease is subject and subordinate, as hereinabove set
forth. 
 Without incurring any liability to Tenant, Landlord may permit access to the Premises and open the same, whether or not Tenant
shall be present, upon any demand of any receiver, trustee, assignee for the benefit of creditors, sheriff, marshal or court officer entitled to, or reasonably purporting to be entitled to, such access for the purpose of taking possession of, or
removing, Tenant’s property or for any other lawful purpose (but this provision and any action by Landlord hereunder shall not be deemed a recognition by Landlord that the person or official making such demand has any right or interest in or to
this Lease, or in or 

  
 43 

 
to the Premises), or upon demand of any representative of the fire, police, building, sanitation or other department of the city, state or federal governments. 

 

	25.	ENTIRE AGREEMENT-WAIVER-SURRENDER 

 25.1 Entire Agreement. This Lease and the
Exhibits made a part hereof contain the entire and only agreement between the parties and any and all statements and representations, written and oral, including previous correspondence and agreements between the parties hereto, are merged herein.
Tenant acknowledges that all representations and statements upon which it relied in executing this Lease are contained herein and that the Tenant in no way relied upon any other statements or representations, written or oral. Any executory agreement
hereafter made shall be ineffective to change, modify, discharge or effect an abandonment of this Lease in whole or in part unless such executory agreement is in writing and signed by the party against whom enforcement of the change, modification,
discharge or abandonment is sought. 
 25.2 Waiver by Landlord. The failure of Landlord to seek redress for violation, or to insist
upon the strict performance, of any covenant or condition of this Lease, or any of the Rules and Regulations promulgated hereunder, shall not prevent a subsequent act, which would have originally constituted a violation, from having all the force
and effect of an original violation. The receipt by Landlord of rent with knowledge of the breach of any covenant of this Lease shall not be deemed a waiver of such breach. The failure of Landlord to enforce any of such Rules and Regulations against
Tenant and/or any other tenant in the Building shall not be deemed a waiver of any such Rules and Regulations. No provisions of this Lease shall be deemed to have been waived by Landlord unless such waiver be in writing signed by Landlord. No
payment by Tenant or receipt by Landlord of a lesser amount than the monthly rent herein stipulated shall be deemed to be other than on account of the stipulated rent, nor shall any endorsement or statement on any check or any letter accompanying
any check or payment as rent be deemed an accord and satisfaction, and Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such rent or pursue any other remedy in this Lease provided. 

25.3 Surrender. No act or thing done by Landlord during the term hereby demised shall be deemed an acceptance of a surrender of the
Premises, and no agreement to accept such surrender shall be valid, unless in writing signed by Landlord. No employee of Landlord or of Landlord’s agents shall have any power to accept the keys of the Premises prior to the termination of this
Lease. The delivery of keys to any employee of Landlord or of Landlord’s agents shall not operate as a termination of the Lease or a surrender of the Premises. In the event that Tenant at any time desires to have Landlord underlet the Premises
for Tenant’s account, Landlord or Landlord’s agents are authorized to receive the keys for such purposes without releasing Tenant from any of the obligations under this Lease, and Tenant hereby relieves Landlord of any liability for loss
of or damage to any of Tenant’s effects in connection with such underletting. 
  

	26.	INABILITY TO PERFORM-EXCULPATORY CLAUSE 

 (a) Except as provided in Articles 4,1 and 4.2
hereof, this Lease and the obligations of Tenant to pay rent hereunder and perform all the other covenants, agreements, terms, provisions and conditions hereunder on the part of Tenant to be performed shall in no way be affected, impaired or excused
because Landlord is unable to fulfill any of its obligations under this Lease or is unable to supply or is delayed in supplying any service expressly or impliedly to be supplied or is unable to make or is delayed in making any repairs, replacements,
additions, alterations, improvements or decorations or is unable to supply or is delayed in supplying any equipment or fixtures if Landlord is prevented or delayed from so doing by reason of strikes or labor troubles or any other similar or
dissimilar cause whatsoever beyond Landlord’s reasonable control, including but not limited to, governmental preemption in connection with a national emergency or by reason of any rule, order or regulation of any department or subdivision
thereof of any governmental agency or by reason of the conditions of supply and demand which have been or are affected by war, hostilities or other similar or dissimilar emergency. In each such instance of inability of Landlord to perform, Landlord
shall exercise reasonable diligence to eliminate the cause of such inability to perform. 

  
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 (b) Tenant shall neither assert nor seek to enforce any claim against Landlord, or
Landlord’s agents or employees, or the assets of Landlord or of Landlord’s agents or employees, for breach of this Lease or otherwise, other than against Landlord’s interest in the Building of which the Premises are a part and in the
uncollected rents, issues and profits thereof, and Tenant agrees to look solely to such interest for the satisfaction of any liability of Landlord under this Lease, it being specifically agreed that in no event shall Landlord or Landlord’s
agents or employees (or any of the officers, trustees, directors, partners, beneficiaries, joint venturers, members, stockholders or other principals or representatives, and the like, disclosed or undisclosed, thereof) ever be personally liable for
any such liability. This paragraph shall not limit any right that Tenant might Otherwise have to obtain injunctive relief against Landlord or to take any other action which shall not involve the personal liability of Landlord to respond in monetary
damages from Landlord’s assets other than the Landlord’s interest in said real estate, as aforesaid. In no event shall Landlord or Landlord’s agents or employees (or any of the officers, trustees, directors, partners, beneficiaries,
joint venturers, members, stockholders or other principals or representatives and the like, disclosed or undisclosed, thereof) ever be liable for consequential or incidental damages. Without limiting the foregoing, in no event shall Landlord or
Landlord’s agents or employees (or any of the officers, trustees, directors, partners, beneficiaries, joint venturers, members, stockholders or other principals or representatives and the like, disclosed or undisclosed, thereof) ever be liable
for lost profits of Tenant. If by reason of Landlord’s failure to acquire title to the real property of which the Premises are a part or to complete construction of the Building or Premises, Landlord shall be held to be in breach of this Lease,
Tenant’s sole and exclusive remedy shall be a right to terminate this Lease. 
 (c) Landlord shall not be deemed to be in default of
its obligations under the Lease unless Tenant has given Landlord written notice of such default, and Landlord has failed to cure such default within thirty (30) days after Landlord receives such notice or such longer period of time as Landlord
may reasonably require to cure such default. Except as otherwise expressly provided in this Lease, in no event shall Tenant have the right to terminate the Lease nor shall Tenant’s obligation to pay Yearly Rent or other charges under this Lease
abate based upon any default by Landlord of its obligations under the Lease. 
  

	27.	BILLS AND NOTICES 

 Any notice, consent, request, bill, demand or statement hereunder by
either party to the other party shall be in writing and, if received at Landlord’s or Tenant’s address, shall be deemed to have been duly given when either delivered, or served personally or sent via overnight mail (via nationally
recognized courier) or mailed by first class mail postage paid certified or registered mail return receipt requested, addressed to Landlord at its address as stated in Exhibit I with a copy to Landlord, c/o Beal and Company, Inc., One Kendall
Square, Building 400, 2nd Floor, Cambridge, Massachusetts 02139; ATTN: Genera! Manager and a copy to Sherin and Lodgen LLP, 101 Federal Street, Boston, Massachusetts 02110, ATTN: Robert M. Carney,
and to Tenant at the Premises (or at Tenant’s address as stated in Exhibit 1, if mailed prior to Tenant’s occupancy of the Premises), and a copy to Wilmer Cutler Pickering Hale and Dorr LLP, 60 State Street, Boston, MA 02109, ATTN: Lia Der
Marderosian, Esq., or if any address for notices shall have been duly changed as hereinafter provided, if mailed as aforesaid to the party at such changed address. Either party may at any time change the address or specify an additional address for
such notices, consents, requests, bills, demands or statements by delivering or mailing, as aforesaid, to the other party a notice stating the change and setting forth the changed or additional address, provided such changed or additional address is
within the United States. 
 If Tenant is a partnership, Tenant, for itself, and on behalf of all of its partners, hereby appoints
Tenant’s Service Partner, as identified on Exhibit 1, to accept service of any notice, consent, request, bill, demand or statement hereunder by Landlord and any service of process in any judicial proceeding with respect to this Lease on behalf
of Tenant and as agent and attorney-in-fact for each partner of Tenant. 
 All bills and statements for reimbursement or other payments or
charges due from Tenant to Landlord hereunder shall be due and payable in full ten (10) days, unless herein otherwise provided, after submission thereof by Landlord to Tenant. Tenant’s failure to make timely payment of any amounts
indicated by such bills and statements, whether for work done by Landlord at Tenant’s request, 

  
 45 

 
reimbursement provided for by this Lease or for any other sums properly owing by Tenant to Landlord, shall be treated as a default in the payment of rent, in which event Landlord shall have all
rights and remedies provided in this Lease for the nonpayment of rent. 
  

	28.	PARTIES BOUND-SEIZING OF TITLE 

 The covenants, agreements, terms, provisions and
conditions of this Lease shall bind and benefit the successors and assigns of the parties hereto with the same effect as if mentioned in each instance where a party hereto is named or referred to, except that no violation of the provisions of
Article 16 hereof shall operate to vest any rights in any successor or assignee of Tenant and that the provisions of this Article 28 shall not be construed as modifying the conditions of limitation contained in Article 21 hereof. 

If, in connection with or as a consequence of the sale, transfer or other disposition of the real estate (land and/or Building, either or
both, as the case may be) of which the Premises are a part. Landlord ceases to be the owner of the reversionary interest in the Premises, Landlord shall be entirely freed and relieved from the performance and observance thereafter of all covenants
and obligations hereunder on the part of Landlord to be performed and observed, it being understood and agreed in such event (and it shall be deemed and construed as a covenant running with the land) that the person succeeding to Landlord’s
ownership of said reversionary interest shall thereupon and thereafter assume, and perform and observe, any and all of such covenants and obligations of Landlord. 
  

	29.	MISCELLANEOUS 

 29.1 Separability. If any provision of this Lease or portion of
such provision or the application thereof to any person or circumstance is for any reason held invalid or unenforceable, the remainder of the Lease (or the remainder of such provision) and the application thereof to other persons or circumstances
shall not be affected thereby. 
 29.2 Captions, etc. The captions are inserted only as a matter of convenience and for reference,
and in no way define, limit or describe the scope of this Lease nor the intent of any provisions thereof. References to “State” shall mean, where appropriate, the Commonwealth of Massachusetts. 

29.3 Broker. Landlord and Tenant each represents and warrants to the other that it has not directly or indirectly dealt, with respect
to the leasing of space in the Building or the Complex of which it is a part (called “Building, etc.” in this Article 29.3) with any broker or had its attention called to the Premises or other space to let in the Building, etc. by anyone
other than the broker, person or firm, if any, designated in Exhibit 1. Tenant agrees to defend, exonerate and save harmless and indemnify Landlord and anyone claiming by, through or under Landlord against any claims for a commission arising out of
the execution and delivery of this Lease or out of negotiations between Landlord and Tenant with respect to the leasing of other space in the Building, etc., provided that Landlord shall be solely responsible for the payment of brokerage commissions
to the broker, person or firm, if any, designated in Exhibit I. Landlord agrees to defend, exonerate and save harmless and indemnify Tenant and anyone claiming by, through or under Tenant against any claims for a commission arising out of the
execution and delivery of this Lease or out of negotiations between Landlord and Tenant with respect to the leasing other space in fee Building. 

29.4 Modifications. If in connection with obtaining financing for the Building, a bank, insurance company, pension trust or other
institutional lender shall request reasonable modifications in this Lease as a condition to such financing. Tenant will not withhold, delay or condition its consent thereto, provided that such modifications do not increase the obligations of Tenant
hereunder or materially adversely affect the leasehold interest hereby created. 
 29.5 Arbitration. Any disputes relating to the
provisions or obligations contained in Articles 2.1, 18 and 20 of this Lease as to which a specific provision for a reference to arbitration is made herein shall be submitted to arbitration in accordance with the provisions of applicable state law
(as identified on 

  
 46 

 
Exhibit 1), as from time to time amended. Arbitration proceedings, including the selection of an arbitrator, shall be conducted pursuant to the rules, regulations and procedures from time to time
in effect as promulgated by the American Arbitration Association. Prior written notice of application by either party for arbitration shall be given to the other at least ten (10) days before submission of the application to the said
Association’s office in the City wherein the Building is situated (or the nearest other city having an Association office). The arbitrator shall hear the parties and their evidence. The decision of the arbitrator shall be binding and
conclusive, and judgment upon the award or decision of the arbitrator may be entered in the appropriate court of law (as identified on Exhibit 1); and the parties consent to the jurisdiction of such court and further agree that any process or notice
of motion or other application to the Court or a Judge thereof may be served outside the State wherein the Building is situated by registered mail or by personal service, provided a reasonable time for appearance is allowed. The costs and expenses
of each arbitration hereunder and their apportionment between the parties shall be determined by the arbitrator in his award or decision. No arbitrable dispute shall be deemed to have arisen under this Lease prior to the expiration of the period of
twenty (20) days after the date of the giving of written notice by the party asserting the existence of the dispute together with a description thereof sufficient for an understanding thereof. 

29.6 Governing Law. This Lease is made pursuant to, and shall be governed by, and construed in accordance with, the laws of the State
wherein the Building is situated and any applicable local municipal rules, regulations, by-laws, ordinances and the like. 
 29.7
Assignment of Rents. With reference to any assignment by Landlord of its interest in this Lease, or the rents payable hereunder, conditional in nature or otherwise, which assignment is made to or held by a bank, trust company, insurance company
or other institutional lender holding a mortgage or ground lease on the Building, Tenant agrees: 
 (a) that the execution thereof by
Landlord and the acceptance thereof by such mortgagee anchor ground lessor shall never be deemed an assumption by such mortgagee and/or ground lessor of any of the obligations of the Landlord hereunder, unless such mortgagee and/or ground lessor
shall, by written notice sent to the Tenant, specifically otherwise elect; and 
 (b) that, except as aforesaid, such mortgagee and/or
ground lessor shall be treated as having assumed the Landlord’s obligations hereunder only upon foreclosure of such mortgagee’s mortgage or deed of trust or termination of such ground lessor’s ground lease and the taking of possession
of the demised Premises after having given notice of its exercise of the option stated in Article 23 hereof to succeed to the interest of the Landlord under this Lease. 

29.8 Representation of Authority. By his or her execution hereof each of the signatories on behalf of the respective parties hereby
warrants and represents to the other that he is duly authorized to execute this Lease on behalf of such party. If Tenant is a corporation, Tenant hereby appoints the signatory whose name appears below on behalf of Tenant as Tenant’s
attorney-in-fact for the purpose of executing this Lease for and on behalf of Tenant. 
 29.9 Expenses Incurred by Landlord Upon Tenant
Requests. Tenant shall, upon demand, reimburse Landlord for all reasonable expenses, including, without limitation, legal fees, incurred by Landlord in connection with all requests by Tenant for consents, approvals or execution of collateral
documentation related to this Lease, including, without limitation, costs incurred by Landlord in the review and approval of Tenant’s plans and specifications in connection with proposed alterations to be made by Tenant to the Premises,
requests by Tenant to sublet the Premises or assign its interest in the Lease, the execution by Landlord of estoppel certificates requested by Tenant, and requests by Tenant for Landlord to execute waivers of Landlord’s interest in
Tenant’s property in connection with third party financing by Tenant Such costs shall be deemed to be additional rent under the Lease. 

29.10 Survival. Without limiting any other obligation of the Tenant which may survive the expiration or prior termination of the term
of the Lease, all obligations on the part of Tenant to indemnify, 

  
 47 

 defend, or hold Landlord harmless, as set forth in this Lease (including, without limitation, Tenant’s
obligations under Articles 13(d), 15.3, and 29.3) shall survive the expiration or prior termination of the term of the Lease. 
 29.11
Hazardous Materials. Landlord and Tenant agree as follows with respect to the existence or use of “Hazardous Material” in or on the Premises, the Building or the Complex. 

(a) Tenant, at its sole cost and expense, shall comply with the Emergency Planning and Community Right to Know Act (EPCRTKA) 42 U.S.C. §
1001-11050, and all other laws, statutes, ordinances, rules and regulations of any local, state or federal governmental authority having jurisdiction concerning environmental, health and safety matters (collectively, “Environmental Laws”),
including, but not limited to, any discharge into the air, surface, water, sewers, soil or groundwater of any Hazardous Material (as defined in Article 29.11(c)), whether within or outside the Premises within the Complex. Notwithstanding the
foregoing, nothing contained in this Lease requires, or shall be construed to require, Tenant to incur any liability related to or arising from environmental conditions (i) for which the Landlord is responsible pursuant to the terms of this
Lease, or (ii) which existed within the Premises or the Complex prior to the date Tenant takes possession of the Premises. 
 (b)
Tenant shall not cause or permit any Hazardous Material to be brought upon, kept or used in or about the Premises or otherwise in the Complex by Tenant, its agents, employees, contractors or invitees, without the prior written consent of Landlord,
except for Hazardous Materials which are typically used in the operation of offices or laboratories, provided that such materials are stored, used and disposed of in strict compliance with, all applicable Environmental Laws and with good scientific
and medical practice. Within five (5) days of Landlord’s request, Tenant shall provide Landlord with a list of all Hazardous Materials, including quantities used and such other information as Landlord may reasonably request, used by Tenant
in the Premises or otherwise in the Complex. Notwithstanding the foregoing, with respect to any of Tenant’s Hazardous Material which Tenant does not properly handle, store or dispose of in compliance with all applicable Environmental Laws and
good scientific and medical practice, Tenant shall, upon written notice from Landlord, no longer have the right to bring such material into the Premises, Building of which the Premises is a part or the Complex until Tenant has demonstrated, to
Landlord’s reasonable satisfaction, that Tenant has implemented programs to thereafter properly handle, store or dispose of such material. 

(c) As used herein, the term “Hazardous Material” means any hazardous or toxic substance, material or waste or petroleum derivative
which is or becomes regulated by any Environmental Law, specifically including live organisms, viruses and fungi, medical waste, and so-called “biohazard” materials. The term “Hazardous Material” includes, without limitation, any
material or substance which is (i) designated as a “hazardous substance” pursuant to Section 1311 of the Federal Water Pollution Control Act (33 U.S.C. Section 1317), (ii) defined as a “hazardous waste”
pursuant to Section 1004 of the Federal Resource Conservation and Recovery Act, 42 U.S.C. Section 6901 et seq. (42 U.S.C. Section 6903), (iii) defined as a “hazardous substance” pursuant to Section 101 of the
Comprehensive Environmental Response, Compensation and Liability Act, 42 U.S.C. Section 9601 et seq. (42 U.S.C. Section 9601), (iv) defined as “hazardous substance” or “oil” under Chapter 21E of the General Laws of
Massachusetts, or (v) a so-called “biohazard” or medical waste, or is contaminated with blood or other bodily fluids; and “Environmental Laws” include, without limitation, the laws listed in the preceding clauses
(i) through (iv). 
 (d) Any increase in the premium for necessary insurance on the Premises or the Complex which arises from
Tenant’s use and/or storage of these Hazardous Materials shall be solely at Tenant’s expense. Tenant shall procure and maintain at its sole expense such additional insurance as may be necessary to comply with any applicable requirement of
any federal, state or local government agency with jurisdiction. 
 (e) Tenant hereby covenants and agrees to indemnify, defend and hold
Landlord harmless from any and all claims, judgments, damages, penalties, fines, costs, liabilities or losses 

  
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(collectively “Losses”) which Landlord may reasonably incur arising out of contamination of real estate, the Complex or other property not a part of the Premises, which contamination
arises as a result of: (i) the presence of Hazardous Material in the Premises, the presence of which is caused or permitted by Tenant, or (ii) from a breach by Tenant of its obligations under this Article 29.11. This indemnification of
Landlord by Tenant includes, without limitation, reasonable costs incurred in connection with any investigation of site conditions or any cleanup, remedial, removal or restoration work required by any federal, state or local governmental agency or
political subdivision because of Hazardous Material present in the soil or ground water on or under the Premises based upon the circumstances identified in the first sentence of this Article 29.11(e). The indemnification and hold harmless
obligations of Tenant under this Article 29.11(e) shall survive any termination of this Lease. Without limiting the foregoing, if the presence of any Hazardous Material in the Building or otherwise in the Complex caused or permitted by Tenant
results in any contamination of the Premises, Tenant shall promptly take all actions at its sole expense as are necessary to return the Premises to a condition which complies with all Environmental Laws; provided that Landlord’s approval of
such actions shall first be obtained, which approval shall not be unreasonably withheld so long as such actions, in Landlord’s reasonable discretion, would not potentially have any materially adverse long-term or short-term effect on the
Premises, and, in any event, Landlord shall not withhold its approval of any proposed actions which are required by applicable Environmental Laws. 

(f) On or before the date that Tenant, and anyone claiming by, through or under Tenant, vacates the Premises, and immediately prior to the
time that Tenant delivers the Premises to Landlord, Tenant shall: 
 (1) Cause the Premises to be decommissioned in
accordance with the regulations of the U.S. Nuclear Regulatory Commission and/or the Massachusetts Department of Public Health for the control of radiation (if applicable), cause the Premises to be released for unrestricted use by the Radiation
Control Program of the Massachusetts Department of Public Health for the control of radiation(if applicable), and deliver to Landlord the report of a certified industrial hygienist stating that he or she has examined the Premises (including visual
inspection, Geiger counter evaluation and airborne and surface monitoring) and found no evidence that such portion contains Hazardous Materials, as defined in this Article 29.11, for which Tenant is responsible under this Lease or is otherwise in
violation of any Environmental Law, as defined in this Article 29.11 hereof. 
 (2) Provide to Landlord a copy of its most
current chemical waste removal manifest and a certification from Tenant executed by an officer of Tenant that no Hazardous Materials or other potentially dangerous or harmful chemicals brought onto the Premises from and after the date that Tenant
first took occupancy of the Premises remain in the Premises. 
 29.12 Patriot Act. 

Tenant represents and warrants to Landlord that: 

(A) Tenant is not in violation of any Anti-Terrorism Law 

(B) Tenant is not, as of the date hereof: 
  

	 	(i)	conducting any business or engaging in any transaction or dealing with any Prohibited Person (as hereinafter defined), including the making or receiving of any contribution of funds, goods or services to or for the
benefit of any Prohibited Person; 

  
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	 	(ii)	dealing in, or otherwise engaging in any transaction relating to, any property or interests in property blocked pursuant to Executive Order No. 13224: or 

 

	 	(iii)	engaging in or conspiring to engage in any transaction that evades or avoids, or has the purpose of evading or avoiding, or attempts to violate any of the prohibitions set forth in, any Anti-Terrorism Law; and

 (C) Neither Tenant nor any of its affiliates, officers, directors, shareholders, members or lease guarantor,
as applicable, is a Prohibited Person. 
 If at any time any of these representations becomes false, then it shall be considered a material
default under this Lease. 
 As used herein, “Anti-Terrorism Law” is defined as any law relating to terrorism, anti-terrorism,
money-laundering or anti-money laundering activities, including without limitation the United States Bank Secrecy Act, the United States Money Laundering Control Act of 1986, Executive Order No. 13224, and Title 3 of the USA Patriot Act, and
any regulations promulgated under any of them. As used herein “Executive Order No. 13224” is defined as Executive Order No. 13224 on Terrorist Financing effective September 24,2001, and relating to “Blocking Property
and Prohibiting Transactions With Persons Who Commit, Threaten to Commit, or Support Terrorism”, as may be amended from time to time. “Prohibited Person” is defined as (i) a person or entity that is listed in the Annex to
Executive Order No. 13224, or a person or entity owned or controlled by an entity that is listed in the Annex to Executive Order No. 13224; (ii) a person or entity with whom Landlord is prohibited from dealing or otherwise engaging in
any transaction by any Anti-Terrorism Law; or (iii) a person or entity that is named as a “specially designated national and blocked person” on the most current list published by the U.S. Treasury Department Office of Foreign Assets
Control at its official website, http://www.treas.gov/ofac/t11sdn.pdf or at any replacement website or other official publication of such list. “USA Patriot Act” is defined as the “Uniting and Strengthening America by Providing
Appropriate Tools Required to Intercept and Obstruct Terrorism Act of 2001” (Public Law 107-56), as may be amended from time to time. 

29.13 Security Deposit/Letter of Credit. In order to secure Tenant’s obligations to Landlord under this Lease, Tenant shall
deliver to Landlord, on the date that Tenant executes and delivers the Lease to Landlord, an Irrevocable Standby Letter of Credit (“Letter of Credit”) which shall be (1) substantially in the form attached hereto as Exhibit 5 or in
such other form as is reasonably acceptable to Landlord, (2) issued by Silicon Valley Bank or another bank reasonably acceptable to Landlord with minimum assets of Ten Billion Dollars ($10,000,000,000.00), upon which presentment may be made in
Massachusetts, (3) in an amount equal to One Hundred Thousand Nine Hundred and Fifty Three and 12/100 ($117,953.12) Dollars and (4) for the period specified below, subject to extension in accordance with the terms of the Letter of Credit.
In the event of a change of circumstance relating to the bank issuing the Letter of Credit, or if Landlord otherwise believes that the financial condition of the issuing bank has been degraded, Landlord reserves the right to require Tenant to
replace the Letter of Credit from time to time with a similar letter of credit issued by another bank satisfactory to Landlord. Tenant shall, on or before the date thirty (30) days prior to the expiration of the term of such Letter of Credit,
deliver to Landlord a new Letter of Credit satisfying the foregoing conditions (“Substitute Letter of Credit”) in lieu of the Letter of Credit then being held by Landlord. Such Letter of Credit shall be automatically renewable provided
that if the issuer of such Letter of Credit gives notice of its election not to renew such Letter of Credit for any additional period pursuant thereto, Tenant shall be required to deliver a Substitute Letter of Credit satisfying the conditions
hereof, on or before the date thirty (30) days prior to the expiration of the term of such Letter of Credit. Tenant agrees that it shall from time to time, as necessary, whether as a result of a draw on the Letter of Credit by Landlord pursuant
to the terms hereof or as a result of the expiration of the Letter of Credit then in effect, renew or replace the original and any subsequent Letter of Credit so that a Letter of Credit, in the amount required hereunder, is in effect throughout term
of this Lease, including any extensions thereof, or in the event that Tenant remains in possession of the premises following the 

  
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expiration of the term, or if Tenant has obligations hereunder to Landlord that remain unsatisfied following the expiration of the term (as may be extended), and for three (3) months after
the latest to occur of the foregoing (i.e., the expiration of the term (as may be extended), the date on which Tenant vacates and yields up the premises, etc.). If Tenant fails to furnish such renewal or replacement at least thirty (30) days
prior to the stated expiration date of the Letter of Credit then held by Landlord, Landlord may draw upon such Letter of Credit and hold the proceeds thereof (and such proceeds need not be segregated) as a security deposit pursuant to the terms of
this Article 29.13. 
 In the event that Tenant is in default of its obligations under the Lease beyond applicable notice and cure periods,
then the Landlord shall have the right, at any time after such event, without giving any further notice to Tenant, to draw down from said Letter of Credit (Substitute Letter of Credit or Additional Letter of Credit, as defined below, as the case may
be) (a) the amount necessary to cure such default or (b) if such default cannot reasonably be cured by the expenditure of money, to exercise all rights and remedies Landlord may have on account of such default, the amount which, in
Landlord’s opinion, is necessary to satisfy Tenant’s liability on account thereof. In the event of any such draw by the Landlord, Tenant shall, within fifteen (15) business days of written demand therefor, deliver to Landlord an
additional Letter of Credit satisfying the foregoing conditions (“Additional Letter of Credit”), except that the amount of such Additional Letter of Credit shall be the amount of such draw. In addition, in the event of a termination based
upon the default of Tenant under the Lease, or a rejection of the Lease pursuant to the provisions of the Federal Bankruptcy Code, Landlord, shall have the right to draw upon the Letter of Credit (from time to time, if necessary) to cover the full
amount of damages and other amounts due from Tenant to Landlord under the Lease. Any amounts so drawn, shall, at Landlord’s election, be applied first to any unpaid rent and other charges which were due prior to the filing of the petition for
protection under the Federal Bankruptcy Code. Tenant hereby covenants and agrees not to oppose, contest or otherwise interfere with any attempt by Landlord to draw down from said Letter of Credit including, without limitation, by commencing an
action seeking to enjoin or restrain Landlord from drawing upon said Letter of Credit. Tenant also hereby expressly waives any-right or claim it may have to seek such equitable relief. In addition to whatever other rights and remedies it may have
against Tenant if Tenant breaches its obligations under this paragraph, Tenant hereby acknowledges that it shall be liable for any and all damages which Landlord may suffer as a result of any such breach. 

Upon request of Landlord or any (prospective) purchaser or mortgagee of the Building, Tenant, shall, at its expense, cooperate with Landlord
in obtaining an amendment to or replacement of any Letter of Credit which Landlord is then holding so that the amended or new Letter of Credit reflects the name of the new owner of the Building or mortgagee, as the case may be. 

To the extent that Landlord has not previously drawn upon any Letter of Credit, Substitute Letter of Credit, Additional Letter of Credit or
Security Proceeds (collectively “Collateral”) held by the Landlord, and the same have not been restored to the full amount of the Security Deposit required hereunder, and to the extent that Tenant is not otherwise in default of its
obligations under the Lease as of the termination date of the Lease, Landlord shall return such Collateral to Tenant within thirty (30) days of the termination of the term of the Lease. 

In no event shall the proceeds of any Letter of Credit be deemed to be a prepayment of rent nor shall it be considered as a measure of
liquidated damages. 
 29.14 Parking. Commencing as of the Term Commencement Date and continuing thereafter throughout the term of
the Lease, the Landlord will make available to Tenant eleven (11) monthly parking passes for use in the One Kendall Square Garage (the “Garage”) which Landlord represents and warrants is owned in fee by it. Tenant shall have no right
to sublet, assign, or otherwise transfer said parking passes except in connection with an assignment of this Lease or sublease of the Premises which is permitted pursuant to the provisions of this Lease. Said parking passes shall be paid for by
Tenant at the then current prevailing rate in the Garage, as such rate may vary from time to time. The current rate for such passes as of the Execution Date of this Lease is $220.00 per month. If, for any reason, Tenant shall fail timely to pay

  
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the charge for said parking passes, Landlord shall have the same rights against Tenant as Landlord has with respect to the timely payment of Yearly Rent hereunder. Said parking passes will be on
an unassigned, non-reserved basis, and shall be subject to reasonable rules and regulations from time to time in force. Tenant shall have the right, from time to time upon at least thirty (30) days prior written notice to Landlord, to surrender
one or more of such parking passes, and upon such surrender, Tenant shall have no further rights or obligations with respect to such surrendered passes. 

29.15 Tenant’s Option to Extend the Term of the Lease. 

A. On the conditions, which conditions Landlord may waive, at its election, by written notice to Tenant at any time, that Tenant is not in
default of its covenants and obligations under the Lease, and that Visterra, Inc., itself, or an Assignee (as defined in Article 16), is occupying at least seventy-five percent (75%) of the Premises then demised to Tenant, both as of the time
of option exercise and as of the commencement of the hereinafter described additional term, Tenant shall have the option to extend the term of this Lease for one (1) additional two (2) year term. Tenant may exercise such option to extend
by giving Landlord written notice at least nine (9) months prior to the end of the then current Lease term. Upon the timely giving of such notice, the term of this Lease shall be deemed extended upon all of the terms and conditions of this
Lease, except that Landlord shall have no obligation to construct or renovate the Premises and that the Yearly Rent during such additional term shall be as hereinafter set forth. If Tenant fails to give timely notice, as aforesaid, Tenant shall have
no further right to extend the term of this Lease, time being of the essence of this Article 29.15. If Tenant fails to timely exercise its rights hereunder, then within seven (7) days of Landlord’s request therefor, Tenant shall execute
and deliver to Landlord a certification, in recordable form, confirming the Tenant’s failure to exercise (or waiver of) such right, and Tenant’s failure to so execute and deliver such certification shall (without limiting Landlord’s
remedies on account thereof) entitle Landlord to execute and deliver to any third party, and record, an affidavit confirming the failure or waiver, which affidavit shall be binding on Tenant and may be conclusively relied on by third parties. 

B. Yearly Rent. The Yearly Rent during the additional term shall be based upon the Fair Market Rental Value, as defined in Article 29.16, as
of the commencement of the additional term, of the Premises then demised to Tenant. 
 C. Tenant shall have no further option to extend the
term of the Lease other than the one (1) additional two (2) year term herein provided. 
 D. Notwithstanding the fact that, upon
Tenant’s exercise of the herein option to extend the term of the Lease, such extension shall be self-executing, as aforesaid, the parties shall promptly execute a lease amendment reflecting such additional term after Tenant exercises the herein
option, except that the Yearly Rent payable in respect of such additional term may not be set forth in said amendment. Subsequently, after such Yearly Rent is determined, the parties shall execute a written agreement confirming the same. The
execution of such lease amendment shall not be deemed to waive any of the conditions to Tenant’s exercise of its rights under this Article 29.15, unless otherwise specifically provided in such lease amendment. 

29.16 Definition of Fair Market Rental Value. 

A. “Fair Market Rental Value” shall be computed as of the date in question at the then current Yearly Rent, including provisions for
subsequent increases and other adjustments for leases or agreements to lease then currently being negotiated, or executed in comparable space located in the Complex and with similar quality laboratory properties in the East Cambridge market. In
determining Fair Market Rental Value, all relevant factors shall be taken into account and given effect, including, without limitation: size, location and condition of Premises, lease term, including renewal options, tenant’s obligations with
respect to operating expenses and taxes, tenant improvement allowances, condition of building, and services and amenities provided by the Landlord. 

  
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 B. Dispute as to Fair Market Rental Value: 

Landlord shall initially designate Fair Market Rental Value and Landlord shall furnish data in support of such designation, both within forty
five (45) days of receiving Tenant’s notice to exercise such option. If Tenant disagrees with Landlord’s designation of a Fair Market Rental Value, Tenant shall notify Landlord, by written notice given within thirty (30) days
after Tenant has been notified of Landlord’s designation, of its disagreement whereupon the parties shall negotiate in good faith to arrive at a mutually agreeable Fair Market Rental Value, if the parties are unable to agree within thirty
(30) days after Tenant’s notice to Landlord, the parties shall submit such Fair Market Rental Value 10 arbitration. Fair Market Rental Value shall be submitted to arbitration as follows: Fair Market Rental Value shall be determined by
impartial arbitrators, one to be chosen by the Landlord, one to be chosen by Tenant, and a third to be selected, if necessary, as below provided. The unanimous written decision of the two first chosen, without selection and participation of a third
arbitrator, or otherwise, the written decision of a majority of three arbitrators chosen and selected as aforesaid, shall be conclusive and binding upon Landlord and Tenant. Landlord and Tenant shall each notify the other of its chosen arbitrator
within ten (10) days following the call for arbitration and, unless such two arbitrators shall have reached a unanimous decision within thirty (30) days after their designation, they shall so notify the President of the Boston Bar
Association (or such organization as may succeed to said Boston Bar Association) and request him or her to select an impartial third arbitrator. All arbitrators shall have at least ten (10) years of professional experience as an office building
owner, real estate manager or real estate broker dealing with like types of properties, to determine Fair Market Rental Value as herein defined. Such third arbitrator and the first two chosen shall, subject to commercial arbitration rules of the
American Arbitration Association, hear the parties and their evidence and render their decision within thirty (30) days following the conclusion of such hearing and notify Landlord and Tenant thereof. Landlord and Tenant shall bear the expense
of the third arbitrator (if any) equally. The decision of the arbitrators shall be binding and conclusive, and judgment upon the award or decision of the arbitrators may be entered in the appropriate court of law (as identified on Exhibit 1); and
the parties consent to the jurisdiction of such court and further agree that any process or notice of motion or other application to the Court or a Judge thereof may be served outside the Commonwealth of Massachusetts by registered mail or by
personal service, provided a reasonable time for appearance is allowed. If the dispute between the parties as to a Fair Market Rental Value has not been resolved before the commencement of Tenant’s obligation to pay rent based upon such Fair
Market Rental Value, then Tenant shall pay Yearly Rent and other charges under the Lease in respect of the Premises in question based upon the Fair Market Rental Value designated by Landlord until either the agreement of the parties as to the Fair
Market Rental Value, or the decision of the arbitrators, as the case may be, at which time Tenant shall pay any underpayment of rent and other charges to Landlord, or Landlord shall refund any overpayment of rent and other charges to Tenant. 

29.17 Roof-Top License. Tenant shall have the nonexclusive license to install, operate and maintain (in a limited number as permitted
by Landlord, in its sole discretion) antennas, satellite dishes and other communication devices (collectively, the “Dish”) on a portion of the roof of the Building (“Roof”) exterior walls or mounted on the ground and compliance
with all of the terms and conditions of this Lease and all of any and all of the specifications relating thereto as reasonably promulgated by and amended by Landlord from time to time (the “Specifications”). Subject to space availability,
Landlord may permit an non-exclusive license to install a supplemental HVAC system (the “HVAC”) on the Roof. In such event, all the provisions contained in this Section 29.17 as they pertain to the Dish, shall also be applicable to
the HVAC, however, it is agreed that Tenant would not be required to remove the HVAC in connection with repairs to the Roof. Tenant acknowledges and agrees that the right granted to Tenant hereunder is a nonexclusive license and is not a lease or an
appurtenant right to the Premises and that Tenant’s liability under this Lease is not contingent or conditioned upon its ability to use the Dish and Tenant shall continue to be obligated to perform all of its obligations under the Lease if
Tenant is unable to use the Dish. Tenant shall only use the Dish to transmit and receive radio transmissions for Tenant’s use in the Premises. No person, or entity other than Tenant shall have the right to use or receive transmissions from the
Dish. The Dish shall be installed at a location on the Roof, exterior Wall or ground, as the case may be, selected by Landlord, in its sole discretion, and Landlord shall have the right to require Tenant to relocate the Dish from time to time, at
Tenant’s sole cost and expense. Landlord makes no representation or warranty to 

  
 53 

 
Tenant that the location selected by Landlord on the Roof, exterior wall or ground, as the case may be, from time to time, will be satisfactory to Tenant or will permit Tenant to receive the
radio transmissions it desires to receive. Prior to installing the Dish, Tenant shall submit to Landlord plans and specifications for the installation of the Dish prepared by a licensed engineer reasonably satisfactory to Landlord (the
“Plans”). The Plans shall be consistent with the Specifications, and otherwise satisfactory to Landlord, and shall show the location of the Dish on the Roof, exterior wall or ground, as the case may be„ the location and type of all
cabling, the way the Dish will be placed on the Roof, exterior wall or ground, as the case may be, and any other information requested by Landlord, in Landlord’s sole discretion. Landlord shall have the right to require that the Dish not be
visible from any location on the ground and/or that the Dish be screened in a manner satisfactory to Landlord, in Landlord’s sole discretion. Landlord shall have the right to employ an engineer or other consultant to review the Plans and the
reasonable cost of such engineer or consultant shall be paid by Tenant to Landlord within thirty (30) days after demand. Landlord may approve or reject all or part of the Plans for any reason, in Landlord’ sole discretion. After Landlord
has approved the Plans and prior to installing the Dish and any cabling, Tenant shall obtain and provide to Landlord: (a) all required governmental and quasi-governmental permits, licenses, special zoning variances and authorizations, all of
which Tenant shall obtain at its own cost and expense; and (b) a policy or certificate of insurance evidencing such insurance coverage as may be required by Landlord. Any alteration or modification of the Dish or any associated cabling after
the Plans have been approved shall require Landlord’s prior written approval, which may be given or withheld in Landlord’s sole discretion. Landlord makes no representation or warranty to Tenant that it will approve the Plans or that
Tenant will be permitted to install the Dish on the Roof, exterior wall or ground, as the case may be, however, Landlord agrees not to unreasonably withhold its consent to such installation. Installation and maintenance of the Dish shall be
performed solely by contractors approved by Landlord, in its sole discretion. Landlord may require Tenant to use a roofing contractor selected by Landlord to perform any work that could damage, penetrate or alter the Roof and an electrician selected
by Landlord to install any cabling on the Roof, exterior walls or in the Building. Landlord may require anyone going on the Roof to execute in advance a liability waiver satisfactory to Landlord, in Landlord’s sole discretion. Tenant shall bear
all costs and expenses incurred in connection with the installation, operation and maintenance of the Dish. Tenant shall pay, when due, all claims for labor or materials furnished or alleged to have been furnished to or for Tenant which claims are
or may be secured by any mechanic’s or materialmen’s lien against the Building, or any interest therein. Tenant acknowledges that Landlord may decide, in its sole discretion, from time to time, to repair or replace the Roof (hereinafter
“Roof Repairs”). If Landlord elects to make Roof Repairs, Tenant shall, upon Landlord’s request, temporarily remove the Dish so that the Roof Repairs may be completed, The cost of removing and reinstalling the Dish shall be paid by
Tenant, at Tenant’s sole cost and expense. Landlord shall not be liable to Tenant for any damages, lost profits or other costs or expenses incurred by Tenant as the result of the Roof Repairs. On the termination or expiration of the Dish
license set forth herein, Tenant shall remove the Dish and all associated cabling and repair any damages caused thereby, at Tenant’s sole cost and expense. If Tenant does not remove the Dish on or before the date this Dish license terminates or
expires, Tenant hereby authorizes Landlord to remove and dispose of the Dish and associated cabling, and Tenant shall immediately reimburse Landlord for the costs and expenses it incurs In removing the Dish and associated cabling and repairing any
damages caused thereby. Tenant agrees that Landlord may dispose of the Dish and any associated cabling, in any manner selected by Landlord. Tenants license to operate and maintain the Dish shall automatically expire and terminate on the date that
the term of the Lease expires or is otherwise terminated. This license shall also terminate if any of the following continue for more than three (3) days after written notice from Landlord to Tenant: (a) the Dish is causing physical damage
to the Building or the Roof, (b) the Dish is interfering with the transmission or receipt of radio signals from or to the Building, (c) the Dish is causing Landlord to be in violation of any agreement to which Landlord is a party or
(d) the Dish is causing Landlord to be in violation any local, state or federal law, regulation or ordinance. In addition, Landlord shall have the right to terminate this Dish license without cause at any time on ninety (90) days advance
written notice to Tenant. In the event of the termination or expiration of the license set forth herein. Tenant agrees to return to rooftop area to its original (or better) condition prior to the Dish installation. 

  
 54 

 IN WITNESS WHEREOF the parties hereto have executed this Indenture of Lease in multiple copies,
each to be considered an original hereof, as a sealed instrument on the day and year noted in Exhibit 1 as the Execution Date. 
  

									
	 LANDLORD:
  

RB KENDALL FEE, LLC
	 		 	 TENANT:
  

VISTERRA, INC.

					
	By:	 	 /s/ Robert L. Beal
	 		 	By:	 	 /s/ Kevin Bitterman

	Name:	 	Robert L. Beal	 		 	(Name)	 	Kevin Bitterman
	Title:	 	Its Authorized Signatory	 		 	(Title)	 	CEO
		 		 		 	Hereunto Duly Authorized

 IF TENANT IS A CORPORATION, A SECRETARY’S OR CLERK’S CERTIFICATE OF THE AUTHORITY AND THE INCUMBENCY
OF THE PERSON SIGNING ON BEHALF OF TENANT SHOULD BE ATTACHED. 

  
 55 

 EXHIBIT 2 

LEASE PLAN 
  

 

 EXHIBIT 2A 

WORK SCOPE 

  
 57 

 

 

 

 

 

 

 

 

 

 
 Visterra 
 Bldg. 300 One
Kendall Square 
 Cambridge, Ma 
  

					
	 Demolition/Temporary Protection/Daily Cleaning
	  	$	18,140	  
	 Concrete
	  	$	0	  
	 Structural Steel
	  	$	0	  
	 Carpentry
	  	$	12,372	  
	 Millwork
	  	$	5,158	  
	 Roofing and Caulking
	  	$	1,200	  
	 Doors/Frames/Hardware
	  	$	5,856	  
	 Glazing
	  	$	10,408	  
	 Gypsum Drywall
	  	$	53,340	  
	 Ceilings
	  	$	35,699	  
	 Resilient Flooring
	  	$	43,306	  
	 Epoxy Flooring
	  	$	3,000	  
	 Painting
	  	$	20,377	  
	 Specialties
	  	$	3,210	  
	 Equipment
	  	$	2,100	  
	 Laboratory Casework
	  	$	29,800	  
	 Fire Protection
	  	$	25,125	  
	 Plumbing
	  	$	156,260	  
	 HVAC
	  	$	241,415	  
	 Electrical and Fire Alarm
	  	$	155,160	  
	 General
	  	$	5,000	  
	 Supervision
	  	$	54,200	  
	 General Conditions
	  	$	30,910	  
	 Engineering
	  	$	0	  
	 Insurance and Permits
	  	$	18,241	  
	 Contingency
	  	$	40,000	  
	 Overhead and Profit
	  	$	38,811	  
		  	  
	  
	 
	 Total
	  	$	1,009,088	  

  

							
	Qualifications	  	
		
	1	  	 Purchase of BSCs is not included

		
	2	  	 No new generator capacity is included

		
	3	  	 Makeup air unit and chiller with associated scope will be base building responsibility and are not
included

		
	4	  	 Toilet room upgrades are not included

		
	5	  	 Security scope; card readers, etc. are not included

		
	6	  	 New DDC control system is not included

		
	7	  	 Tel/Data cabling is not included

		
	8	  	 Shafts for new makeup air ductwork from the roof are not included

		
	9	  	 Start up and repair of relocated equipment is not included

		
	10	  	 Start up and repair existing neutralization system is not included

		
	11	  	 For each week of project overlap beyond the five weeks assumed in this proposal, an additional $5,400 may be
deducted

		
	Alternates	  	
				
	1	  	Upgrade existing fire alarm to synchronize devices	  	Add	  	$7,350

  
 Page 1 of 1 

 

 
 Visterra 
 Bldg. 300 One
Kendall Square 
 Cambridge, Ma 
  

																			
	 Division/Description
	  	Qty	 	  	UM	  	Unit $	 	  	Line Sum	 	  	Div. Sum	 
	 Demolition/Temporary Protection/Daily Cleaning
	  				  		  				  				  			
	 Demolition by Beal
	  				  		  				  	 	NIC	  	  			
	 Temporary protection
	  				  		  				  				  			
	 Floor protection
	  	 	70	  	  	shts	  	 	22	  	  	 	1,540	  	  			
	 Casework protection
	  	 	30	  	  	shts	  	 	22	  	  	 	660	  	  			
	 Dust protection material
	  	 	1	  	  	ls	  				  	 	2,500	  	  			
	 Daily cleaning
	  	 	28	  	  	days	  	 	480	  	  	 	13,440	  	  			
		  				  		  				  				  	$	18,140	  
						
	 Concrete
	  				  		  				  				  			
	 Equipment housekeeping pads
	  				  		  				  	 	NIC	  	  			
						
	 Structural Steel
	  				  		  				  				  			
	 Reinforcement for new roof top makeup air unit – By base building
	  				  		  				  	 	NIC	  	  			
						
	 Carpentry
	  				  		  				  				  			
	 Door and Hardware installation
	  	 	8	  	  	days	  	 	884	  	  	 	7,072	  	  			
	 Misc. carpentry
	  	 	1	  	  	ls	  				  	 	3,500	  	  			
	 Barricades/safety rails
	  	 	3	  	  	mos	  	 	600	  	  	 	1,800	  	  			
		  				  		  				  				  	$	12,372	  
						
	 Millwork
	  				  		  				  				  			
	 Conference/room serving counter
	  				  		  				  	 	NIC	  	  			
	 Existing casework to remain in the kitchen area
	  				  		  				  	 	N/A	  	  			
	 Reception desk allowance
	  				  		  				  	 	NIC	  	  			
	 Remove existing kitchen cabinets (Demo contractor)
	  	 	6	  	  	hrs	  	 	68	  	  	 	408	  	  			
	 Furnish and install 8’ new upper/lower kitchen cabinets and top
	  	 	1	  	  	alw	  	 	2,850	  	  	 	2,850	  	  			
	 Relaminate gray lab countertops in place
	  	 	1	  	  	alw	  	 	1,900	  	  	 	1,900	  	  			
		  				  		  				  				  	$	5,158	  
						
	 Roofing and Caulking
	  				  		  				  				  			
	 Roof Work
	  				  		  				  				  			
	 No scope identified
	  				  		  				  	 	NIC	  	  			
	 Caulking
	  				  		  				  				  			
	 Interior sealants
	  	 	1	  	  	ls	  				  	 	1,200	  	  			
		  				  		  				  				  	$	1,200	  
						
	 Doors/Frames/Hardware
	  				  		  				  				  			
	 Re-use existing
	  				  		  				  	 	N/A	  	  			
	 Add 2’×7’ sidelight frame at all office and conference room doors
	  	 	16	  	  	ea	  	 	366	  	  	 	5,856	  	  			
		  				  		  				  				  	$	5,856	  
						
	 Glazing
	  				  		  				  				  			
	 Sidelights at offices and conference room doors
	  	 	16	  	  	Ea	  	 	268	  	  	 	4,288	  	  			
	 One pair  1⁄2” tempered doors with entry
hardware
	  	 	1	  	  	Pr	  	 	6,120	  	  	 	6,120	  	  			
		  				  		  				  				  	$	10,408	  
						
	 Gypsum Drywall
	  				  		  				  				  			
	 Walls 6” above ceiling
	  	 	314	  	  	if	  	 	110	  	  	 	34,540	  	  			
	 Walls to deck
	  	 	110	  	  	If	  	 	130	  	  	 	14,300	  	  			
	 Repairs at perimeter
	  	 	1	  	  	ls	  				  	 	2,000	  	  			
	 Misc. patch/repair
	  	 	1	  	  	ls	  				  	 	2,500	  	  			
		  				  		  				  				  	$	53,340	  
						
	 Ceilings
	  				  		  				  				  			
	 Existing ceilings to remain in the lobby and toilet rooms
	  				  		  				  	 	NIC	  	  			
	 Offices – 2 4 Dune second look in fine line grid
	  	 	5,572	  	  	sf	  	 	3.75	  	  	 	20,895	  	  			
	 General lab – 2 X 4 lay in file in 15/16” grid
	  	 	3,316	  	  	sf	  	 	3.75	  	  	 	11,760	  	  			
	 Tissue Culture and Infectivity – 2X4 viny faced tile
	  	 	460	  	  	sf	  	 	4.65	  	  	 	2,139	  	  			
	 Remove and repair ceilings at second floor for utility access
	  	 	500	  	  	sf	  	 	1.81	  	  	 	905	  	  			
		  				  		  				  				  	$	35,699	  

  
 1 of 4 

																			
	 Division/Description
	  	Qty	 	  	UM	  	Unit $	 	  	Line Sum	 	  	Div. Sum	 
						
	 Resilient Flooring
	  				  		  				  				  			
	 Vendor quotation
	  	 	1	  	  	ls	  				  	 	38,306	  	  			
	 Existing sheet vinyl to remain in the two main laboratories
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 VCT in Analytical, TC Supplies, Stockroom 2, Small Molecule, Bacterial, Equipment/Stockroom 1, Shipping/Receiving, Clinical Storage and
IT
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Sheet vinyl in Tissue Culture and Infectivity
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Carpet in conference rooms, offices and corridors
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Vinyl base at all new and existing walls
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Entry lobby Flooring to remain
	  	 	1	  	  	ls	  				  	 	NIC	  	  			
	 Floor preparation
	  	 	1	  	  	alw	  				  	 	5,000	  	  			
		  				  		  				  				  	$	43,306	  
						
	 EPOXY FLOORING
	  				  		  				  				  			
	 Glasswash
	  				  		  				  				  			
	 Seamless roller applied with integral base
	  	 	1	  	  	ls	  				  	 	3,000	  	  			
	 Prep surface
	  	 	1	  	  	ls	  				  	 	inc	  	  			
		  				  		  				  				  	$	3,000	  
						
	 Painting
	  				  		  				  				  			
	 Vendor quote
	  	 	1	  	  	ls	  				  	 	12,825	  	  			
	 Paint all new and existing partitions within the tenant space
	  	 	1	  	  	ls	  				  	 	Inc. above	  	  			
	 Paint all new and existing door frames within the tenant space
	  	 	1	  	  	ls	  				  	 	Inc. above	  	  			
	 Common area
	  	 	1,900	  	  	sf	  	 	1.10	  	  	 	2,090	  	  			
	 Door and frames
	  	 	5	  	  	ea	  	 	160.00	  	  	 	800	  	  			
	 Lobby walls and ceiling
	  	 	800	  	  	sf	  	 	1.10	  	  	 	880	  	  			
	 Elevator doors
	  	 	2	  	  	ea	  	 	180.00	  	  	 	360	  	  			
	 Painted finish at mechanical room floor
	  				  		  				  	 	NIC	  	  			
	 Remove and tag existing lighting to be eletro painted white
	  	 	8	  	  	hrs	  	 	103.00	  	  	 	824	  	  			
	 Prop and electrostatic paint red fixtures
	  	 	1	  	  	alw	  	 	850.00	  	  	 	950	  	  			
	 Reinstall light fixtures
	  	 	16	  	  	hrs	  	 	103.00	  	  	 	1,648	  	  			
		  				  		  				  				  	$	20,377	  
						
	 Specialties
	  				  		  				  				  			
	 Fire extinguishers and cabinets Reuse existing
	  				  		  				  	 	NIC	  	  			
	 Window Treatments Existing to remain
	  				  		  				  	 	NIC	  	  			
	 Corner guards
	  	 	10	  	  	ea	  	 	186	  	  	 	1,860	  	  			
	 Electrical projection screen
	  	 	1	  	  	ea	  	 	1,350	  	  	 	1,350	  	  			
	 Signage By Tenant
	  				  		  				  	 	NIC	  	  			
		  				  		  				  				  	$	3,210	  
						
	 Equipment
	  				  		  				  				  			
	 Cold room startup; recharge; standard PM
	  	 	1	  	  	alw	  				  	 	1,500	  	  			
	 Autoclave – Relocate existing
	  				  		  				  	 	NIC	  	  			
	 Glasswasher Relocate existing
	  				  		  				  	 	NIC	  	  			
	 Biosafety cabinets By owner
	  				  		  				  	 	NIC	  	  			
	 Ice maker Relocate existing
	  				  		  				  	 	NIC	  	  			
	 Kitchen refrigerator by lenang
	  				  		  				  	 	NIC	  	  			
	 Kitchen dishwasher
	  	 	1	  	  	ls	  	 	600	  	  	 	600	  	  			
		  				  		  				  				  	$	2,100	  
						
	 Laboratory Casework
	  				  		  				  				  			
	 Chemical fume hoods 6’ Re-use existing located by Beal
	  				  		  				  	 	NIC	  	  			
	 Furnish and install hood base cabinets; install hoods
	  	 	1	  	  	ls	  				  	 	6,000	  	  			
	 Relocate one existing fume hood
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Glassware storage cabinet
	  				  		  				  	 	NIC	  	  			
	 Wire shelving in stockrooms
	  				  		  				  	 	NIC	  	  			
	 Casework – assumes reuse of existing in Bacterial Lab
	  	 	1	  	  	ls	  				  	 	12,600	  	  			
	 Shelving
	  	 	1	  	  	ls	  				  	 	6,800	  	  			
	 Repair existing casework as indicated
	  	 	1	  	  	ls	  				  	 	1,000	  	  			
	 Scullery sink in Glasswash
	  	 	1	  	  	ls	  				  	 	3,600	  	  			
	 Laboratory labels By tenant
	  	 	1	  	  	ls	  				  	 	NIC	  	  			
		  				  		  				  				  	$	29,800	  
						
	 Fire Protection
	  				  		  				  				  			
	 Vendor budget based on relocation of approximately heads
	  	 	75	  	  	hds	  	 	335	  	  	 	25,125	  	  			
		  				  		  				  				  	$	25,125	  

  
 2 of 4 

																			
	 Division/Description
	  	Qty	 	  	UM	  	Unit $	 	  	Line Sum	 	  	Div. Sum	 
						
	 Plumbing
	  				  		  				  				  			
	 Quote per drawings and revised BOD
	  	 	1	  	  	ls	  				  	 	151,260	  	  			
	 Lab waste
	  				  		  				  				  			
	 New lab waste and vent piping connected to existing neutralization system
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 New lab sinks
	  	 	3	  	  	ea	  				  	 	inc. above	  	  			
	 Floor drains at glasswash
	  	 	4	  	  	ea	  				  	 	inc. above	  	  			
	 Tepid water
	  				  		  				  				  			
	 Modifications to make system code compliant
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 New eyewash/emergency shower units
	  	 	2	  	  	ea	  				  	 	inc. above	  	  			
	 Sink eyewash units
	  	 	2	  	  	ea	  				  	 	inc. above	  	  			
	 Utilities
	  				  		  				  				  			
	 Changeover manifolds for nitrogen and carbon dioxide
	  	 	2	  	  	ea	  				  	 	inc. above	  	  			
	 Distribution piping per the equipment utility matrix
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Natural gas
	  				  		  				  				  			
	 Demo existing piping; cut and cap
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 RODI
	  				  		  				  				  			
	 Distribution piping to glasswasher, glasswash sink, Tissue Culture sink and to one sink in each of the two large labs
	  				  		  				  	 	inc. above	  	  			
	 Allowance to restart existing RODI system
	  	 	1	  	  	alw	  				  	 	5,000	  	  			
		  				  		  				  				  	$	156,260	  
						
	 HVAC
	  				  		  				  				  			
	 Office area
	  				  		  				  				  			
	 New make up air duct
	  	 	1	  	  	ls	  				  	 	11,000	  	  			
	 Heat pump relocation and duct connections
	  	 	1	  	  	ls	  				  	 	20,375	  	  			
	 New duct distribution and terminals
	  	 	1	  	  	ls	  				  	 	12,500	  	  			
	 Piping modification
	  	 	1	  	  	ls	  				  	 	5,250	  	  			
	 Insulation
	  	 	1	  	  	ls	  				  	 	2,400	  	  			
	 Condensate drains
	  	 	1	  	  	ls	  				  	 	400	  	  			
	 Balancing
	  	 	1	  	  	ls	  				  	 	1,320	  	  			
	 Controls
	  	 	1	  	  	ls	  				  	 	700	  	  			
	 Laboratories
	  				  		  				  				  			
	 Selective demolition
	  	 	1	  	  	ls	  				  	 	9,000	  	  			
	 Heat pump modifications in analytical area
	  	 	1	  	  	ls	  				  	 	6,800	  	  			
	 Supply boxes for hood makeup
	  	 	1	  	  	ls	  				  	 	3,500	  	  			
	 Ductwork modifications
	  	 	1	  	  	ls	  				  	 	76,200	  	  			
	 Equipment furnish and install
	  	 	1	  	  	ls	  				  	 	29,300	  	  			
	 Insulation
	  	 	1	  	  	ls	  				  	 	5,600	  	  			
	 Balancing
	  	 	1	  	  	ls	  				  	 	4,200	  	  			
	 Controls
	  	 	1	  	  	ls	  				  	 	22,000	  	  			
	 Hot water reheat
	  				  		  				  				  			
	 Piping material and labor
	  	 	1	  	  	ls	  				  	 	22,115	  	  			
	 Hot water coils
	  	 	9	  	  	ea	  	 	545	  	  	 	4,905	  	  			
	 Insulation
	  	 	1	  	  	ls	  				  	 	3,850	  	  			
		  				  		  				  				  	$	241,415	  
	 Electrical and Fire Alarm
	  				  		  				  				  			
	 Vendor quotation Estimated
	  	 	1	  	  	quote	  				  	 	154,800	  	  			
	 Demolition – Make safe; disconnect equipment for relocation
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Temporary lighting and power
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Misc. power wiring
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Power to all offices
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Systems furniture feeds
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 AV conduit for large conference room
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Projector power
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Conference room floor boxes
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Laboratory power
	  				  		  				  				  			
	 Fume hood connections
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Equipment connections per the utility matrix
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 60 A connections for glasswasher and autoclave
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Modify existing wiremold to remain
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Power at ceiling for labels
	  	 	16	  	  	ea	  				  	 	inc. above	  	  			
	 Lighting
	  				  		  				  				  			
	 Reuse fixtures where possible
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Switching to conform to floor plan
	  	 	8	  	  	ea	  				  	 	inc. above	  	  			
	 Exist signs
	  	 	8	  	  	ea	  				  	 	inc. above	  	  			
	 Emergency light battery units
	  	 	8	  	  	ea	  				  	 	inc. above	  	  			
	 Fire alarm
	  				  		  				  				  			
	 Horn strobe devices
	  	 	14	  	  	ea	  				  	 	inc. above	  	  			
	 Strobe only devices
	  	 	2	  	  	ea	  				  	 	inc. above	  	  			
	 Programming and testing
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Mechanical power
	  				  		  				  				  			
	 Allowance for power to new HVAC equipment
	  	 	1	  	  	ls	  				  	 	inc. above	  	  			
	 Tel/Data Rough
	  				  		  				  				  			
	 Cabling By tenant
	  	 	1	  	  	ls	  				  	 	NIC	  	  			
	 Security By base building
	  				  		  				  				  			
	 Add power for electrical screen
	  	 	1	  	  	ea	  	 	360	  	  	 	360	  	  			
		  				  		  				  				  	$	155,160	  

  
 3 of 4 

																			
	 Division/Description
	  	Qty	 	  	UM	  	Unit $	 	  	Line Sum	 	  	Div. Sum	 
						
	 General
	  				  		  				  				  			
	 Fire watch
	  				  		  				  	 	NIC	  	  			
	 FACP shutdown fees
	  				  		  				  	 	NIC	  	  			
	 MEP relocations due to interference with new systems
	  	 	1	  	  	ls	  				  	 	5,000	  	  			
	 Police details
	  				  		  				  	 	NIC	  	  			
						
		  				  		  				  				  	$	5,000	  
						
	 Supervision
	  				  		  				  				  			
	 Project Executive
	  				  		  				  	 	N/A	  	  			
	 Estimator
	  				  		  				  	 	N/A	  	  			
	 Project Manager @  1⁄2 time
	  	 	14	  	  	wks	  	 	1,900	  	  	 	26,600	  	  			
	 Project Superintendent
	  	 	14	  	  	wks	  	 	3,600	  	  	 	50,400	  	  			
	 Assume 5 weeks overlap for supervision and project management with other projects in this building
	  	 	5	  	  	wks	  	 	-5,400	  	  	 	-27,000	  	  			
	 Project Administrative Assistant
	  	 	5	  	  	days	  	 	420	  	  	 	2,100	  	  			
	 Project Accountant
	  	 	5	  	  	days	  	 	420	  	  	 	2,100	  	  			
		  				  		  				  				  	$	54,200	  
						
	 General Conditions
	  				  		  				  				  			
	 Field operation expenses
	  	 	12	  	  	wks	  	 	780	  	  	 	9,360	  	  			
	 Field office construction
	  	 	1	  	  	ls	  				  	 	3,000	  	  			
	 Reproduction of contract documents
	  	 	1	  	  	ea	  	 	1,500	  	  	 	1,500	  	  			
	 Dumpsters
	  	 	14	  	  	ea	  	 	675	  	  	 	9,450	  	  			
	 Safety/protection/barricades
	  	 	14	  	  	wks	  	 	150	  	  	 	2,100	  	  			
	 Final cleaning
	  	 	1	  	  	ls	  				  	 	5,500	  	  			
		  				  		  				  				  	$	30,910	  
						
	 Engineering
	  				  		  				  				  			
	 Architectural design – By others
	  				  		  				  	 	NIC	  	  			
	 Structural design – By others
	  				  		  				  	 	NIC	  	  			
	 MEP engineering – by others
	  				  		  				  	 	NIC	  	  			
						
	 Insurance and Permits
	  				  		  				  				  			
	 General Liability Insurance
	  	 	0.50	  	  	%	  				  	 	4,560	  	  			
	 Building Permits
	  	 	1.50	  	  	%	  				  	 	13,681	  	  			
		  				  		  				  				  	$	18,241	  
		  	  
	  
	 	  	  
	  				  	  
	  
	 	  	  
	  
	 
	 Contingency
	  	 	1	  	  	ls	  				  	 	40,000	  	  	$	40,000	  
		  	  
	  
	 	  	  
	  				  	  
	  
	 	  	  
	  
	 
	 Overhead and Profit
	  	 	4.00	  	  	%	  				  				  	$	38,811	  
		  	  
	  
	 	  	  
	  				  				  	  
	  
	 
	 Total Budget
	  				  		  				  				  	$	1,009,008	  

  

									
	Qualifications	  		
		
	1	  	Purchase of BSCs is not included	  
		
	2	  	No new generator capacity is included	  
		
	3	  	Makeup air unit and chiller with associated scope will be base building responsibility and are not included	  
		
	4	  	Toilet room upgrades are not included	  
		
	5	  	Security scope; card readers, etc. are not included	  
		
	6	  	New DDC control system is not included	  
		
	7	  	Tel/Data cabling is not included	  
		
	8	  	Shafts for new makeup air ductwork from the roof are not included	  
		
	9	  	Start up and repair of existing equipment to be relocated is not included	  
		
	10	  	Start up and repair existing neutralization system is not included	  
		
	11	  	For each week of project overlap beyond the assumed five weeks in this proposal, an additional $5,400 may be deducted	   
		
	Alternates	  		
				
	1	  	Upgrade existing fire alarm to synchronize devices	  	Add	  	$	7,350	  

  
 4 of 4 

 

 

 EXHIBIT 2B PLAN 

SHOWING LOCATION OF ANS 
  

 

 EXHIBIT 2C INCLUDED FURNITURE 

BUILDING 300 3rd Floor FURNITURE INVENTORY 
  

									
	 Room #
	  	 Type
	  	Quantity	  	 Description
	  	Photo #
	 1
	  	Reception Desk	  	1	  	L-shaped desk with wood top; dark grey metal file drawers	  	1
					
	 1
	  	Chair	  	6	  	Lt. blue fabric chairs with black metal legs	  	1
					
	 2
	  	Work Table	  	3	  	30×60 work tables w/beige metal legs; wood-tone formica top	  	2
					
	 2
	  	Chair	  	8	  	Burgundy fabric chairs with black metal legs	  	2
					
	 2
	  	White Board	  	2	  	48×96 wall-mounted white board in metal frame	  	3
					
	 3
	  	Desk	  	1	  	L-shaped desk with light grey top/black metal legs, 3-2 drawer files and 1-3 drawer file	  	4
					
	 4
	  	Desk	  	1	  	L-shaped desk with light grey top/black metal legs and 1-3 drawer file	  	6
					
	 4
	  	White Board	  	1	  	36×48 wall-mounted white board in metal frame	  	3
					
	 5
	  	Desk	  	1	  	L-shaped desk with light grey top/black metal legs, 1-2 drawer files and 1-3 drawer file	  	7
					
	 5
	  	White Board	  	1	  	36×48 wall-mounted white board in metal frame	  	3
					
	 6
	  	Desk	  	1	  	L-shaped desk with light grey top/black metal legs and 1-3 drawer file	  	8
					
	 7
	  	Work Table	  	1	  	Work table with grey plastic top, black metal legs	  	9
					
	 7
	  	Shelf Unit	  	1	  	Wood shelf unit	  	9
					
	 8
	  	Lab Table	  	1	  	30×96×36 Lab table with black top/beige legs	  	10
					
	 9
	  	Utility Shelf	  	1	  	5-tier plastic utility shelf	  	
					
	 Lab Area
	  	White Board	  	1	  	36×48 wall-mounted white board in metal frame	  	3
					
	 Lab Area
	  	Bulletin Board	  	4	  	36×60 wall-mounted bulletin board in wood frame	  	
					
	 10
	  	Desk	  	1	  	U-shaped desk with wood top with 1-2 drawer and 1-3 drawer dark grey metal file cabinets	  	16
					
	 10
	  	Cubicle Cabinet	  	1	  	Double dark grey metal cubicle cabinet w/bulletin board	  	16
					
	 10
	  	White Board	  	1	  	36×48 wall-mounted white board in metal frame	  	3
					
	 11
	  	Desk	  	1	  	U-shaped desk with wood top with 1-2 drawer and 1-3 drawer dark grey metal file cabinets	  	16
					
	 11
	  	Cubicle Cabinet	  	1	  	Double dark grey metal cubicle cabinet w/bulletin board	  	16
					
	 11
	  	White Board	  	1	  	36×48 wall-mounted white board in metal frame	  	3
					
	 12
	  	Desk	  	1	  	2-station desk with wood top with 2-2 drawer and 2-3 drawer dark grey file cabinets	  	19

									
	 Room #
	  	 Type
	  	Quantity	  	 Description
	  	Photo #
	 12
	  	Cubicle Cabinet	  	1	  	Double dark grey metal cubicle cabinet w/bulletin board	  	19
					
	 12
	  	Work Table	  	1	  	18×48 work table with formica top/black metal legs	  	20
					
	 12
	  	White Board	  	1	  	48×96 wall-mounted white board in metal frame	  	3
					
	 13
	  	Desk	  	1	  	U-shaped desk with wood top with 1-2 drawer and 1-3 drawer dark grey metal file cabinets	  	21
					
	 13
	  	Cubicle Cabinet	  	1	  	Double dark grey metal cubicle cabinet w/bulletin board	  	19
					
	 13
	  	White Board	  	1	  	36×48 wall-mounted white board in metal frame	  	3
					
	 14
	  	Desk	  	1	  	U-shaped desk with wood top with 1-2 drawer and 1-3 drawer dark grey metal file cabinets	  	21
					
	 14
	  	Cubicle Cabinet	  	1	  	Double dark grey metal cubicle cabinet w/bulletin board	  	19
					
	 14
	  	White Board	  	1	  	36×48 wall-mounted white board in metal frame	  	3
					
	 14
	  	Bookcase	  	1	  	2-shelf black bookcase	  	22
					
	 15
	  	Desk	  	1	  	U-shaped desk with wood top with 1-2 drawer and 1-3 drawer dark grey metal file cabinets	  	21
					
	 15
	  	Cubicle Cabinet	  	1	  	Double dark grey metal cubicle cabinet w/bulletin board	  	19
					
	 15
	  	White Board	  	1	  	36×48 wall-mounted white board in metal frame	  	3
					
	 16
	  	Desk	  	1	  	U-shaped desk with wood top with 1-2 drawer and 1-3 drawer dark grey metal file cabinets	  	21
					
	 16
	  	Cubicle Cabinet	  	1	  	Double dark grey metal cubicle cabinet w/bulletin board	  	19
					
	 16
	  	White Board	  	1	  	48×96 wall-mounted white board in metal frame	  	3
					
	 17
	  	Desk	  	1	  	U-shaped desk with wood top with 1-2 drawer and 1-3 drawer dark grey metal file cabinets	  	21
					
	 17
	  	Cubicle Cabinet	  	1	  	Double dark grey metal cubicle cabinet w/bulletin board	  	19
					
	 17
	  	White Board	  	1	  	36×48 wall-mounted white board in metal frame	  	3
					
	 18
	  	Cubicles	  	3	  	Sets grey/black fabric cubicles with desk and 1-3 drawer file cabinet	  	24, 25
					
	 18
	  	Cubicle Cabinet	  	3	  	Double dark grey metal cubicle cabinet w/bulletin board	  	19
					
	 18
	  	Desk	  	1	  	U-shaped desk with wood top with 1-2 drawer and 1-3 drawer dark grey metal file cabinets	  	25
					
	 18
	  	White Board	  	1	  	36×48 wall-mounted white board in metal frame	  	3
					
	 19
	  	Conference Table	  	1	  	8’Boat-shaped 2-pc. wood conference table	  	27

									
	 Room #
	  	 Type
	  	Quantity	  	 Description
	  	Photo #
	 19
	  	Executive Chair	  	4	  	Black executive swivel chairs with arms	  	27
					
	 20
	  	Desk	  	1	  	Lt. grey desk with 1-2 drawer and 1-3 drawer file drawers	  	25
					
	 20
	  	Bookcase	  	1	  	Black 5-shelf bookcase	  	34
					
	 21
	  	Work Table	  	2	  	Work tables w/beige metal legs; wood-tone formica top	  	28, 29
					
	 21
	  	Chair	  	10	  	Blue plastic chairs with chrome legs	  	28, 29
					
	 21
	  	White Board	  	1	  	48×96 wall-mounted white board in metal frame	  	29
					
	 21
	  	Bulletin Board	  	1	  	36×48 wall-mounted bulletin board in wood frame	  	
					
	 22
	  	Conference Table	  	1	  	192×53 2-pc. Wood top conference table with black metal legs	  	30
					
	 22
	  	Chair	  	11	  	Lt. blue fabric chair with black metal legs	  	7, 30
					
	 22
	  	White Board	  	1	  	Folding white board w/bulletin board – wood finish	  	30, 31
					
	 22
	  	Projection Screen	  	1	  	7’ Retractable projection screen	  	32
					
	 22
	  	Credenza	  	1	  	20×72 4-door black wood credenza	  	33
					
	 23
	  	Desk	  	1	  	U-shaped desk with wood top with 1-2 drawer and 1-3 drawer dark grey metal file cabinets	  	21
					
	 23
	  	White Board	  	1	  	48×96 wall-mounted white board in metal frame	  	3
					
	 24
	  	Desk	  	1	  	2-station desk with wood top with 1-2 drawer and 2-3 drawer dark grey file cabinets (1 drawer missing from 3-drawer file cabinet)	  	19
					
	 24
	  	Cubicle Cabinet	  	2	  	Double dark grey metal cubicle cabinet w/bulletin board	  	19
					
	 24
	  	Bookcase	  	1	  	Black metal 4-shelef bookcase	  	34
					
	 25
	  	Desk	  	1	  	U-shaped desk with wood top with 1-2 drawer and 1-3 drawer dark grey metal file cabinets	  	21
					
	 25
	  	Cubicle Cabinet	  	1	  	Double dark grey metal cubicle cabinet w/bulletin board	  	19
					
	 25
	  	White Board	  	1	  	36×48 wall-mounted white board in metal frame	  	3
					
	 26
	  	Desk	  	1	  	4-station U-shaped desk with wood top with 4- 2 drawer files and 4- 3 drawer dark grey metal file cabinets	  	35
					
	 26
	  	Cubicle Cabinet	  	2	  	Double dark grey metal cubicle cabinet w/bulletin board	  	36
					
	 26
	  	White Board	  	1	  	36×48 wall-mounted white board in wood frame	  	

 

 

 EXHIBIT 3 

PLAN OF COMPLEX 
  

 

 EXHIBIT 4 

TERM COMMENCEMENT DATE AGREEMENT 

                    
(“Tenant”) hereby certifies that it has entered into a lease with RB KENDALL FEE, LLC (“Landlord”) dated             . 20     [, as
amended by                      dated             ,
20    ,] and verifies the following information as of the              day of 200  : 

 

			
	Address of Building:	  	Building             , One Kendall Square, Cambridge, MA 02139
		
	Number of Rentable Square Feet in Premises:	  	                     r.s.f.
		
	Term Commencement Date:	  	            , 20    
		
	Rent Commencement Date:	  	            ,. 20    
		
	Lease Termination Date:	  	            , 20    
		
	Tenant’s Proportionate Common Share:	  	    %
		
	Tenant’s Proportionate Building Share:	  	    %

 Tenant acknowledges and agrees that all improvements Landlord is obligated to make to the Premises, if any,
have been completed to Tenant’s satisfaction, that Tenant has accepted possession of the Premises, and that as of the date hereof there exist no offsets or defenses to the obligations of Tenant under the Lease. 

 

									
	TENANT:	 		 	LANDLORD:
			
	  
	 		 	RB KENDALL FEE, LLC
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	  
	 		 	Name:	 	Robert L. Beal
	Title:	 	  
	 		 	Title:	 	Its Authorized Signatory
		 	Hereunto duly authorized	 		 		 	

 IRREVOCABLE STANDBY LETTER OF CREDIT NO.
                     
 DATED 

 

 EXHIBIT 5 

FORM OF LETTER OF CREDIT 
 IRREVOCABLE STANDBY
LETTER OF CREDIT NO, 
 DATE:                     

 BENEFICIARY: 
 RB KENDALL FEE, LLC 

c/o Beal and Company, Inc. 
 177 Milk Street 

Boston, MA 02109 
 AS “LANDLORD” 

 

	
	APPLICANT:
	
	  

	Building             
	One Kendall Square, MA 02139
	AS “TENANT”

 AMOUNT: US $        
(                     
 AND 00/100 U.S.
DOLLARS)’ 
 EXPIRATION DATE:
                     
 LOCATION: AT OUR
COUNTERS IN BOSTON, MASSACHUSETTS 
 DEAR SIR/MADAM: 

WE HEREBY ESTABLISH OUR IRREVOCABLE STANDBY LETTER OF CREDIT NO.
                     IN YOUR FAVOR AVAILABLE BY YOUR DRAFT BRAWN ON US AT SIGHT IN THE FORM OF EXHIBIT “B” ATTACHED AND ACCOMPANIED
BY THE FOLLOWING DOCUMENTS: 
 1. THE ORIGINAL OF THIS LETTER OF CREDIT AND ALL AMENDMENTS), IF ANY. 

2. A DATED CERTIFICATION FROM THE BENEFICIARY SIGNED BY AN AUTHORIZED OFFICER OR AGENT, FOLLOWED BY ITS DESIGNATED TITLE, STATING THE FOLLOWING: 

(A) “THE AMOUNT REPRESENTS FUNDS DUE AND OWING TO US FROM APPLICANT PURSUANT TO THAT CERTAIN LEASE BY AND BETWEEN BENEFICIARY, AS
LANDLORD, AND APPLICANT, AS TENANT.” 
 OR 

(B) “WE HEREBY CERTIFY THAT WE HAVE RECEIVED NOTICE FROM
                     BANK THAT LETTER OF CREDIT NO.
                     WILL NOT BE RENEWED, AND THAT WE HAVE NOT RECEIVED A REPLACEMENT OF THIS LETTER OF CREDIT FROM APPLICANT SATISFACTORY TO
US AT LEAST THIRTY (30) DAYS PRIOR TO THE EXPIRATION DATE OF THIS LETTER OF CREDIT.” 

  

 IRREVOCABLE STANDBY LETTER OF CREDIT NO.
                     
 DATED 

 

 THE LEASE AGREEMENT MENTIONED ABOVE IS FOR IDENTIFICATION PURPOSES ONLY AND IT IS NOT INTENDED THAT SAID
LEASE AGREEMENT BE INCORPORATED HEREIN OR FORM PART OF THIS LETTER OF CREDIT. 
 OUR OBLIGATION UNDER THIS CREDIT SHALL NOT BE AFFECTED BY ANY
CIRCUMSTANCES, CLAIM OR DEFENSE, REAL OR PERSONAL OF ANY PARTY AS TO THE ENFORCEABILITY OF THE LEASE BETWEEN YOU AND TENANT, IT BEING UNDERSTOOD THAT OUR OBLIGATION SHALL BE THAT OF A PRIMARY OBLIGOR AND NOT THAT OF A SURETY, GUARANTOR OR
ACCOMMODATION MAKER. IF YOU DELIVER THE WRITTEN CERTIFICATE REFERENCED ABOVE TO US, (I) WE SHALL HAVE NO OBLIGATION TO DETERMINE WHETHER ANY OF THE STATEMENTS THEREIN ARE TRUE, (II) OUR OBLIGATIONS HEREUNDER SHALL NOT BE AFFECTED IN ANY MANNER
WHATSOEVER IF THE STATEMENTS MADE IN SUCH CERTIFICATE ARE UNTRUE IN WHOLE OR IN PART, AND (III) OUR OBLIGATIONS HEREUNDER SHALL NOT BE AFFECTED IN ANY MANNER WHATSOEVER IF TENANT DELIVERS INSTRUCTIONS OR CORRESPONDENCE TO WHICH EITHER
(A) DENIES THE TRUTH OF THE STATEMENT SET FORTH IN THE CERTIFICATE REFERRED TO ABOVE, OR (B) INSTRUCTS US NOT TO PAY BENEFICIARY ON THIS CREDIT FOR ANY REASON WHATSOEVER. 

PARTIAL AND MULTIPLE DRAWS ARE ALLOWED. EXCEPT AS EXPRESSLY SET FORTH HEREIN, THIS LETTER OF CREDIT MUST ACCOMPANY ANY DRAWINGS HEREUNDER FOR ENDORSEMENT OF
THE DRAWING AMOUNT AND WILL BE RETURNED TO THE BENEFICIARY UNLESS IT IS FULLY UTILIZED. 
 DRAFT(S) AND DOCUMENTS MUST INDICATE THE NUMBER AND DATE OF THIS
LETTER OF CREDIT. 
 THIS LETTER OF CREDIT SHALL BE AUTOMATICALLY EXTENDED FOR AN ADDITIONAL PERIOD OF ONE YEAR, WITHOUT AMENDMENT, FROM THE PRESENT OR EACH
FUTURE EXPIRATION DATE UNLESS AT LEAST SIXTY (60) DAYS PRIOR TO THE THEN CURRENT EXPIRATION DATE WE NOTIFY YOU BY REGISTERED MAE-OVERNIGHT COURIER SERVICE AT THE ABOVE ADDRESSES THAT THIS LETTER OF CREDIT WILL NOT BE EXTENDED BEYOND THE CURRENT
EXPIRATION DATE. IN NO EVENT SHALL THIS LETTER OF CREDIT BE AUTOMATICALLY EXTENDED BEYOND THREE (3) MONTHS BEYOND LEASE EXPIRATION. 
 THIS LETTER OF
CREDIT MAY BE TRANSFERRED WITHOUT COST TO THE BENEFICIARY, ONE OR MORE TIMES BUT IN EACH INSTANCE TO A SINGLE BENEFICIARY AND ONLY IN THE FULL AMOUNT AVAILABLE TO BE DRAWN UNDER THE LETTER OF CREDIT AT THE TIME OF THE TRANSFER AND ONLY BY THE
ISSUING BANK. UPON OUR RECEIPT OF THE ATTACHED “EXHIBIT A” DULY COMPLETED AND EXECUTED BY THE BENEFICIARY AND ACCOMPANIED BY THE ORIGINAL LETTER OF CREDIT AND ALL AMENDMENTS, IF ANY. 

ALL DEMANDS FOR PAYMENT SHALL BE MADE BY PRESENTATION OF THE ORIGINAL APPROPRIATE DOCUMENTS PRIOR TO 10:00 A.M. E.S.T. TIME, ON A BUSINESS DAY AT OUR OFFICE
(THE “BANK’S OFFICE”) AT: (                    ) 

  

 IRREVOCABLE STANDBY LETTER OF CREDIT NO.
                     
 DATED 

 

 BOSTON, MASSACHUSETTS
                    , ATTENTION:
                     OR BY FACSIMILE TRANSMISSION AT:
(617)             -            ; AND SIMULTANEOUSLY UNDER TELEPHONE ADVICE TO:
(617)             -            ; ATTENTION:
                     WITH ORIGINALS TO FOLLOW BY OVERNIGHT COURIER SERVICE. 

PAYMENT AGAINST CONFORMING PRESENTATIONS HEREUNDER SHALL BE MADE BY BANK DURING NORMAL BUSINESS HOURS OF THE BANK’S OFFICE WITHIN ONE (1) BUSINESS
DAY AFTER PRESENTATION. 
 WE HEREBY AGREE WITH THE DRAWERS, ENDORSERS AND BONAFIDE HOLDERS THAT THE DRAFTS DRAWN UNDER AND IN ACCORDANCE WITH THE TERMS AND
CONDITIONS OF THIS LETTER OF CREDIT SHALL BE DULY HONORED UPON PRESENTATION TO THE DRAWEE, IF NEGOTIATED ON OR BEFORE THE EXPIRATION DATE OF THIS CREDIT. 

THIS LETTER OF CREDIT IS SUBJECT TO THE UNIFORM CUSTOMS AND PRACTICE FOR DOCUMENTARY CREDITS (1993 REVISION), INTERNATIONAL CHAMBER OF COMMERCE, PUBLICATION
NO. 500. 
  

					
	  
	 		 	  

	AUTHORIZED SIGNATURE	 		 	AUTHORIZED SIGNATURE

  

 EXHIBIT “A” 
  

					
	 DATE:                     
	 		  	
			
	 TO:                     
	 		  	
			
		 		  	RE: STANDBY LETTER OF CREDIT NO. ISSUED
	 BY
	 		  	
	 ATTN:
	 		  	L/C AMOUNT:             

 LADIES AND GENTLEMEN: 

FOR VALUE RECEIVED, THE UNDERSIGNED BENEFICIARY HEREBY IRREVOCABLY TRANSFERS TO: 

(NAME OF TRANSFEREE) 
 (ADDRESS) 

ALL RIGHTS OF THE UNDERSIGNED BENEFICIARY TO DRAW UNDER THE ABOVE LETTER OF CREDIT UP TO ITS AVAILABLE AMOUNT AS SHOWN ABOVE AS OF THE DATE OF THIS
TRANSFER. 
 BY THIS TRANSFER, ALL EIGHTS OF THE UNDERSIGNED BENEFICIARY IN SUCH LETTER OF CREDIT ARE TRANSFERRED TO THE TRANSFEREE. TRANSFEREE SHALL
HAVE THE SOLE RIGHTS AS BENEFICIARY THEREOF, INCLUDING SOLE RIGHTS RELATING TO ANY AMENDMENTS, WHETHER INCREASES OR EXTENSIONS OR OTHER AMENDMENTS, AND WHETHER NOW EXISTING OR HEREAFTER MADE, ALL AMENDMENTS ARE TO BE ADVISED DIRECT TO THE TRANSFEREE
WITHOUT NECESSITY OF ANY CONSENT OF OR NOTICE TO THE UNDERSIGNED BENEFICIARY. 
 THE ORIGINAL OF SUCH LETTER OF CREDIT IS RETURNED HEREWITH, AND WE
ASK YOU TO ENDORSE THE TRANSFER ON THE REVERSE THEREOF, AND FORWARD IT DIRECTLY TO THE TRANSFEREE WITH YOUR CUSTOMARY NOTICE OF TRANSFER. 
  

			
	SINCERELY,	  	
		
	  
	  	
	 (BENEFICIARY’S NAME)
	  	
	
	  

			
	SIGNATURE OF BENEFICIARY	  	
	
	  

	SIGNATURE AUTHENTICATED

			
		
	  
	  	
	 (NAME OF BANK)
	  	

			
	
	  

	AUTHORIZED SIGNATURE	  	

 EXHIBIT “B” 
  

									
	DATE:
                    	 	 REF. NO.
                    
	  	 
	 			 
	AT SIGHT OF THIS DRAFT	 		 		  	 
	 
	PAY TO THE ORDER OF
                                         
                                         
                   US $             
	 			 
	USDOLLARS	 		 		  	 
	 	 
	  
	  	 
	 	 
	  
	  	 
	 
	DRAWN UNDER
                     BANK, BOSTON, MASSACHUSETTS, STANDBY LETTER OF CREDIT NUMBER NO.
                     DATED
                    
	TO:	 	  
	 	BANK	 	 
	 	 	  
	 		 	 
	 	 	  
	 	, MA             	 	  

	 	 		 	                        
        (BENEFICIARY’S NAME)
	 			 
	 	 	 	 	 	 	  

Authorized Signature

 EXHIBIT 6 

TENANT’S PERSONAL PROPERTY 
 1. Autoclave
installed in connection with the Tenant’s Improvements 
 2. Glassware Washer installed in connection with the Tenant’s Improvements 

3. Other items of personal property installed by Tenant in accordance with the Lease after the Term Commencement Date 

 COMMENCEMENT DATE AGREEMENT 

VISTERRA, INC. (“Tenant”) hereby certifies that it has entered into a lease with RB KENDALL FEE, LLC
(“Landlord”) dated September 2, 2010 (the “Lease”) and verifies the following information as of the 11th day of March, 2011. Capitalized terms used, but not herein
defined, shall have the meaning ascribed in the Lease: 
  

			
	Address of Building:	  	Building 300, One Kendall Square, Cambridge, MA 02139
		
	Number of Rentable Square Feet in Premises:	  	 *7,000 r.s.f.
 11,750 r.s.f.

		
	Term Commencement Date:	  	March 11, 2011
		
	Rent Commencement Date:	  	March 11, 2011
		
	Lease Termination Date:	  	March 31, 2015
		
	Tenant’s Proportionate Common Share:	  	 *1.09%
 1.84%

		
	Tenant’s Proportionate Building Share:	  	 *10.83%
 18.19%

		
	Initial Yearly Rent	  	$301,000.00 annually

 Tenant acknowledges and agrees that all improvements Landlord is obligated to make to the Premises, if any,
have been completed to Tenant’s satisfaction, that Tenant has accepted possession of the Premises, and that as of the date hereof, there exist no offsets or defenses to the obligations of Tenant under the Lease. 

 

	*	Year 1 (3/11/11 through 3/31/12) 

									
			
	TENANT:	 		 	LANDLORD:
			
	VISTERRA, INC.	 		 	RB KENDALL FEE, LLC
					
	By:	 	 /s/ Peter Courossi
	 		 	By:	 	 /s/ Robert L. Beal

	Name:	 	Peter Courossi	 		 	Name:	 	Robert L. Beal
	Title:	 	Chief Financial Officer	 		 	Title:	 	Its Authorized Signatory
		 	Hereunto duly authorized	 		 		 	

 FIRST AMENDMENT OF LEASE 

THIS FIRST AMENDMENT OF LEASE (this “Amendment”) is made as of this 31st day of January, 2015 (the
“Execution Date”), by and between DWF IV ONE KENDALL, LLC, a Delaware limited liability company having an address c/o Divco West Real Estate Services, Inc., One Kendall Square, Cambridge, MA 02139, Attention: Property
Manager (“Landlord”) and VISTERRA, INC., a Delaware corporation having a mailing address at One Kendall Square, Building 300, Cambridge, Massachusetts 02139 (“Tenant”). 

BACKGROUND: 
 A.
Reference is made to an Indenture of Lease dated September 2, 2010, by and between RB Kendall Fee, LLC, as landlord, and Tenant (the “Lease”), demising approximately 11,750 rentable square feet of space on the third
floor of Building 300 (the “Premises”) in One Kendall Square, Cambridge, Massachusetts. Capitalized terms used, but not defined herein shall have the same meaning as in the Lease. 

B. Landlord is the successor to RB Kendall Fee, LLC, and Landlord and Tenant are the current holders, respectively, of the lessor’s and
lessee’s interests in the Lease. 
 C. The term of the Lease expires on March 31, 2015. 

D. Landlord and Tenant now desire to amend the Lease to extend the term of the Lease beyond March 31, 2015, all as more particularly set
forth herein. 
 AGREEMENTS: 

NOW, THEREFORE, in consideration of the mutual covenants and agreements herein contained, and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree to amend the Lease as follows: 
 1. Extension
of Term. The term of the Lease is hereby extended beyond March 31, 2015 for the period beginning on April 1, 2015 and ending on March 31, 2017 (the “Additional Term”). The Additional Term shall be upon all
of the same terms and conditions of the Lease in effect as of the date hereof except as otherwise set forth herein. Tenant acknowledges and agrees that it currently occupies the Premises and is familiar with the condition thereof and that the
Premises is leased to Tenant in “As-Is” condition without any representation or warranty, express or implied, as to the condition or fitness for Tenant’s use thereof. Tenant agrees that Landlord has no work to perform in or on the
Premises to prepare same for Tenant’s use and occupancy. 
 2. Payment of Yearly Rent, Operating Expense Share and Tax Share During
Additional Term. Throughout the Additional Term, in addition to all other amounts due and payable by Tenant under the Lease, Tenant shall pay to Landlord monthly installments of Yearly Rent as follows and otherwise as set forth in the Yearly
Rent payment provisions of the Lease: 

					
	 Period
	  	Monthly
Rent	 
	 April 1, 2015-March 31, 2016
	  	$	52,875.00	  
	 April 1, 2016-March 31, 2017
	  	$	54,461.25	  

 In addition to the payment of Yearly Rent for the Premises, throughout the Additional Term, Tenant shall also
pay the Operating Expense Share pursuant to Section 9.3 of the Lease and the Tax Share pursuant to Section 9.2 of the Lease. 
 3.
Electricity Payments During Additional Term. In addition to the Yearly Rent and other amounts payable under the Lease, during the Additional Term, Tenant shall continue to be obligated to pay for its electricity usage in the Premises in
accordance with the provisions of Article 8 of the Lease. 
 4. Further Extension. Tenant acknowledges and agrees that,
notwithstanding anything in the Lease to the contrary, Tenant shall have no further right to extend the term of the Lease beyond the Additional Term. Accordingly, (a) Section 29.15 of the Lease is hereby deleted in its entirety and of no
force or effect, and (b) on or before March 31, 2017, Tenant shall quit, vacate and yield-up the Premises in broom clean condition and free from all personal property, furniture, fixtures, inventory and equipment and otherwise in
accordance with the surrender provisions of the Lease, including, without limitation, that Tenant shall perform the decommissioning requirements set forth in Section 29.11(f) of the Lease and Section 7 of this Amendment. 

5. No Option to Terminate. The second paragraph of Section 3.2 of the Lease is hereby deleted in its entirety and of no force or
effect. 
 6. Additional Term Allowance. So long as Tenant is not in default under the Lease, and no event or condition exists which
with notice and/or the expiration of any grace period would constitute a default under the Lease, Landlord shall provide to Tenant an amount not to exceed $94,000 (the “Additional Term Allowance”) in the aggregate to be applied
towards all so-called “hard” and “soft” costs of construction incurred by Tenant after the date of this Amendment in performing improvements and alterations to the Premises; provided, however, that no more than twenty percent
(20%) of the Additional Term Allowance shall be used for architectural, engineering and other “soft” costs of construction. Disbursements of the Additional Term Allowance shall be made by Landlord within thirty (30) days
following Landlord’s receipt of Tenant’s written request, which request shall be accompanied by customary documentation supporting the charges for completion of such improvements and alterations. Such documentation shall be of a scope and
detail sufficient to satisfy a commercial construction lender operating in the market area in which the Building is located and shall include copies of paid invoices and, to the extent applicable, partial lien waivers or full lien

  
 2 

 
waivers (in the case of the final disbursement). 
 Any alterations and improvements
to the Premises by Tenant shall be subject to the requirements set forth in Article 12 of the Lease. In addition, Tenant’s compliance with Article 12 of the Lease shall be a condition to Landlord’s obligation hereunder to make any
disbursement of the Additional Term Allowance. Any portion of the Additional Term Allowance that has not been requested by Tenant in writing as a reimbursement on or before October 1, 2015 shall be deemed forfeited by Tenant, and Landlord shall
have no further obligation with respect thereto. 
 7. Hazardous Materials. Without in any way limiting or restricting Tenant’s
obligations under Section 29.11 of the Lease, Tenant represents and warrants that the list attached hereto as Exhibit 7 is a complete list of all Hazardous Materials and quantities used by Tenant in the Premises as of the Execution Date.
Exhibit 7 attached to the Lease is hereby deleted in its entirety and replaced with Exhibit 7 attached hereto. Tenant shall not use or permit to exist in the Premises any Hazardous Materials other than those listed on Exhibit 7
(the “Permitted Hazardous Materials and Quantities”): provided, however, that, subject to the following provisions of this Section 7, Tenant may make reasonable adjustments to the types of Hazardous Materials and
quantities used or stored in the Premises so long as: 
  

	 	(a)	such types and quantities of Hazardous Materials are materially consistent with the types and quantities of the Permitted Hazardous Materials and Quantities and are necessary to Tenant’s business; and

  

	 	(b)	Tenant has obtained and maintains all licenses, permits, registrations and consents required by applicable law (including, without limitation, Environmental Laws) to use or store all such types and quantities of
Hazardous Materials in the Premises; and 

  

	 	(c)	Within ten (10) days of Landlord’s written request from time to time, Tenant shall have provided Landlord with a revised, updated Exhibit 7 reflecting the reasonable adjustments made by Tenant.

 Notwithstanding the foregoing, under no circumstances shall Tenant use or permit to exist in the Premises, or obtain any
license, permit, registration or consent from any Governmental Authority (as defined below) permitting Tenant to use or store in the Premises: 
  

	 	(i)	any of the Hazardous Materials or classes thereof listed and/or identified on Schedule 1 attached hereto, and 

  

	 	(ii)	any Hazardous Materials subject to regulation under 780 CMR 307 that would cause the limitations on quantities of classes of such Hazardous Materials (as set forth in the “Tenant Storage Permitted” column on
Schedule 2 attached hereto) to be exceeded. 

  
 3 

 Tenant shall promptly provide Landlord with copies of any license, permit, registration or
consent relating to the use or storage of Hazardous Materials that are obtained or renewed during the Lease term. In addition, at Landlord’s written request, Tenant shall complete a Hazardous Materials audit checklist, in a form reasonably
acceptable to Landlord, at least annually or at sooner intervals upon Landlord’s written request if Landlord has reason to believe that Tenant has violated the provisions of this Section 7 or other provisions of the Lease governing
Hazardous Materials. In addition, Tenant shall not permit the imposition of any lien by any local, federal or state governmental agency, authority, commission, board or the like (each, a “Governmental Authority”) or other
party to secure payment for damages caused by, or the recovery of any costs or expenses for, the cleanup, remediation, investigation, release or threatened release of any Hazardous Material brought to or used at the Premises by Tenant, its
employees, contractors or agents or any other person for whom Tenant is responsible. Tenant also shall provide Landlord with prompt written notice in reasonable detail of (i) any release or threatened release at, on, under or from the Premises
of which Tenant becomes aware which would reasonably be expected to exceed reportable quantities or give rise to a violation of any Environmental Laws, or which could result in a legal obligation to investigate or remediate Hazardous Materials
pursuant to, Environmental Laws; (ii) any notice received by Tenant, or of which Tenant has knowledge, from any Governmental Authority in connection with any such release or any violation of Environmental Laws, or in connection with the
presence or alleged presence of any Hazardous Materials at the Premises; or (iii) any incurrence of expense by any Governmental Authority or other party in connection with the assessment, containment or removal of any Hazardous Materials
located at, on, in, or under, or emanating from the Premises. For purposes of the indemnity provisions set forth in Section 29.11(e) of the Lease, a breach by Tenant of the provisions of this Section 7 shall be deemed to be a breach under
Article 29.11 of the Lease. 
 In addition to the provisions of Section 29.11(f) of the Lease, upon the expiration or earlier
termination of the Lease, Tenant and anyone claiming by, through, or under Tenant, shall (A) provide Landlord with a completed Laboratory Decommissioning Checklist in the form of Schedule 3 attached hereto on or before the date that
Tenant, and anyone claiming by, through or under Tenant, vacates the Premises, and immediately prior to the time that Tenant delivers the Premises to Landlord, (B) decommission all laboratory space in the Premises, including without limitation,
to the extent required to deliver a complete Laboratory Decommissioning Checklist, and otherwise in accordance with applicable laws and best practices for similarly used laboratory space, and to the satisfaction of any Governmental Authority
involved in the closure, (C) terminate or transfer to another location, all licenses, permits, registrations and consents obtained by Tenant for the use or storage of Hazardous Materials at the Premises, (D) dispose of or remove from the
Premises all Hazardous Materials stored in the Premises in compliance with applicable laws (including, without limitation, all Environmental Laws and any other laws applicable to the transportation of Hazardous Materials), (E) decontaminate all
surfaces and fixed equipment in the Premises, and (F) review and remediate any specific Hazardous Materials that may be associated with any laboratory fixtures used by Tenant in the Premises. 

8. Amendments to EXHIBIT 1, SHEET 1 of Lease. EXHIBIT 1, SHEET 1 of the 

  
 4 

 
Lease is hereby amended as follows: 
  

	 	(a)	The mailing address for Landlord under EXHIBIT 1, SHEET 1 shall be deleted and the following shall be substituted therefor: 

  

			
	 Landlord
 Mailing
Address:
	  	 DWF IV One Kendall, LLC
 c/o Divco West Real
Estate Services, Inc.
 One Kendall Square
 Cambridge, MA

02139 Attention: Property Manager

	  
 With copies to:
	  	  
 DWF IV One Kendall, LLC

c/o Divco West Real Estate Services, Inc.
 575 Market Street, 35th Floor
 San Francisco, CA 94105

Attn: Asset Manager
  

and
  

Nutter, McClennen & Fish LLP
 Seaport West 155 Seaport
Boulevard
 Boston, MA 02210
 Attn: Timothy M. Smith,
Esq.

  

	 	(b)	The following shall be inserted as the Rent Payment Address under EXHIBIT 1, SHEET 1: 

“Rent Payment Address: Tenant shall make rent and other payments under the Lease in accordance with the instructions and to the
addresses as noted below, which payment instructions and addresses may be changed by written notice from Landlord to Tenant. 
  

	 	(1)	Tenant shall make all checks, in payment of rent and other sums due to Landlord under this Lease, payable to the order of DWF IV ONE KENDALL, LLC, as mortgagor, for the benefit of GERMAN AMERICAN CAPITAL CORPORATION, as
mortgagee, Account No. 432916030 and 

  

	 	(2)	Tenant shall deliver such checks or otherwise make such payment as follows: 

  
 5 

			
	 By Mail:
   City
National Bank
   P.O. Box 7129

  San Francisco, CA 94120-7502
	  	
		
	 By Wire:

  Account Name:

  Account Number:

  Bank Name:

  Bank Address:
  

  ABA Routing #:

  Swift #:

  Contact:
	  	 DWF IV One Kendall, LLC
 432916030

City National Bank - CBS/SF
 150 California Street, 13th Floor
 San Francisco, CA 94111

USA
 1220-1606-6

CINAUS6L
 Hoa Pham (415) 284-5700”

 9. Brokers. Landlord and Tenant each represents and warrants to the other party that it has not
authorized, retained or employed, or acted by implication to authorize, retain or employ, any real estate broker or salesman to act for it or on its behalf in connection with this Amendment so as to cause the other party to be responsible for the
payment of a brokerage commission, except for Cushman & Wakefield of Massachusetts and RBJ/Transwestern (collectively, the “Brokers”‘). Any fees payable to the Brokers are the responsibility of Landlord pursuant
to separate written agreement with the Brokers. Landlord and Tenant shall each indemnify, defend and hold the other party harmless from and against any and all claims by any real estate broker or salesman (other than the Brokers) whom the
indemnifying party authorized, retained or employed, or acted by implication to authorize, retain or employ, to act for the indemnifying party in connection with this Amendment. 

10. Tenant’s Continuing Obligation To Maintain Letter of Credit Under Section 29.13 of the Lease. Landlord is currently
holding, as security for Tenant’s obligations under the Lease, the Letter of Credit described in Section 29.13 of the Lease in the amount of $117,953.12 (the “Letter of Credit”). For and during the Additional Term:
(a) Landlord shall continue to hold the Letter of Credit as security for Tenant’s obligations under the Lease; (b) Landlord shall have the right to draw down the Letter of Credit, if necessary, in accordance with the provisions of
Section 29.13 of the Lease; and (c) Tenant shall be obligated to comply with the provisions of Section 29.13 with respect to maintaining, reviewing and replacing, as necessary, the Letter of Credit. 

11. Counterpart Execution. This Amendment may be executed in counterparts, each of which shall be deemed an original and all of which
when taken together shall constitute one fully executed original Amendment, binding upon the parties hereto, notwithstanding that all of the parties hereto may not be signatories to the same counterpart. Additionally, telecopied or emailed
signatures may be used in place of original signatures on this Amendment. Landlord and 

  
 6 

 
Tenant intend to be bound by the signatures on the telecopied or e-mailed document, are aware that the other party will rely on the telecopied or e-mailed signatures, and hereby waive any
defenses to the enforcement of the terms of this Amendment based on the form of signature. 
 12. Miscellaneous. In all other
respects, the Lease shall remain unmodified and shall continue in full force and effect, as amended hereby. The parties hereby ratify, confirm, and reaffirm all of the terms and conditions of the Lease, as amended hereby. Tenant represents and
warrants to Landlord that, as of the date hereof, (a) Tenant is not in default under any of the terms and provisions of the Lease, (b) there are no uncured defaults or unfulfilled obligations on the part of Landlord under the Lease, and
(c) no condition or circumstance exists which, with the giving of notice or the passage of time or both, would constitute a default by Landlord under the Lease. Tenant further acknowledges that Tenant has no defenses, offsets, liens, claims or
counterclaims against Landlord under the Lease or against the obligations of Tenant under the Lease (including, without limitation, any rental payments or other charges due or to become due under the Lease). 

13. Authorization to Execute. Tenant represents and warrants to Landlord that the person signing this Amendment on behalf of Tenant is
duly authorized to execute and deliver this Amendment on behalf of Tenant in accordance with a duly adopted resolution or other applicable authorization of Tenant, and that this Amendment is binding upon Tenant in accordance with its terms. Further,
if requested by Landlord, Tenant shall, within thirty (30) days after such request, deliver to Landlord a certified copy of a resolution or other applicable authorization of said organization authorizing or ratifying the execution of this
Amendment. 
 14. No Reservation. Preparation of this Amendment by Landlord or Landlord’s attorney and the submission of this
Amendment to Tenant for examination or signature is without prejudice and does not constitute a reservation, option or offer to lease the Premises. This Amendment shall not be binding or effective until this Amendment shall have been executed and
delivered by each of the parties hereto, and Landlord reserves the right to withdraw this Amendment upon written notice to Tenant from consideration or negotiation at any time prior to Landlord’s execution and delivery of this Amendment, which
withdrawal shall be without prejudice, recourse or liability. 
 [Signatures on Following Page] 

  
 7 

 IN WITNESS WHEREOF the parties hereto have executed this First Amendment of Lease on the date
first written above in multiple copies, each to be considered an original hereof, as a sealed instrument. 
  

									
		 	LANDLORD:
		
		 	 DWF IV ONE KENDALL, LLC, a Delaware limited liability company

				
		 		 	By:	 	Divco West Real Estate Services, Inc.,
		 		 		 	a Delaware corporation, its Agent
					
		 		 		 	By:	 	 /s/ James Teng

		 		 		 	Name:	 	James Teng
		 		 		 	Title:	 	Managing Director
		
		 	TENANT:
		
		 	 VISTERRA, INC., a Delaware corporation

			
		 	 By:
	 	 /s/ David Arkowitz

		 	 Name:
	 	David Arkowitz
		 	 Title:
	 	C.O.O. & C.F.O.

  
 8 

 Exhibit 7 

List of Hazardous Materials and Quantities 
  

																									
	Visterra Hazardous Chemical Inventory	  	As of Dec. 2014
	 Chemical Name
	  	Laboratory	  	CZ	  	s’ ‘l’
‘g’	  	Quant	  	Vol/
Mass	  	UOM	  	Gal	  	Lbs	  	Ft1	  	CAS	  	Peroxide
Former	  	Notes
	Surface Amos 80	  	R	  		  	l	  	6	  	10	  	Ml	  	0.02	  	no value	  	no value	  		  		  	
	Poly(ethylene Glycol)	  	R	  		  	s	  	1	  	1	  	kg	  	no value	  	2.20	  	no value	  	25322-68-3	  		  	
	Potassium phosphate monobasic	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	7778-77-0	  		  	
	Poly(ethylene Glycol)	  	R	  		  	s	  	1	  	250	  	gr	  	no value	  	0.55	  	no value	  	25322-68-3	  		  	
	Phenazlne meth sulfate 99%	  	R	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	299-11-6	  		  	
	Potassium carbonate 99.995%	  	R	  		  	s	  	1	  	10	  	gr	  	no value	  	0.02	  	no value	  	584-08-7	  		  	
	polyethylene mine	  	R	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	9002-98-6	  		  	
	Piperasinc dihydrochiodride mononydrate 98	  	R	  		  	s	  	1	  	250	  	gr	  	no value	  	0.55	  	no value	  	6091-62-9	  		  	
	Potassium phosphate dioasic	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	7758-11-4	  		  	
	Methyla-D-mannooyanoside	  	R	  		  	s	  	2	  	25	  	gr	  	no value	  	0.11	  	no value	  	617-04-9	  		  	
	Poly(ethylene Glycol)	  	R	  		  	l	  	1	  	500	  	ml	  	0.13	  	no value	  	no value	  	25322-68-3	  		  	
	Methyla-D-mannooyanoside	  	R	  		  	s	  	2	  	100	  	gr	  	no value	  	0.44	  	no value	  	617-04-9	  		  	
	Magnesium chloride hexahydrate 99%	  	R	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	7791-18-6	  		  	
	Ponceaus	  	R	  		  	s	  	1	  	10	  	gr	  	no value	  	0.02	  	no value	  	6226-79-5	  		  	
	NP-40 Surfact Amos Detergent Solution	  	R	  		  	l	  	1	  	50	  	ml	  	0.01	  	no value	  	no value	  		  		  	
	Nickle(II) sulfate mexahydrate 90-%	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	10101-97-0	  		  	
	Magnesium chloride	  	R	  		  	s	  	2	  	100	  	gr	  	no value	  	0.44	  	no value	  	7786-30-3	  		  	
	MOPS	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	1132-61-2	  		  	
	Nichelous sulfate, 6-hydrate, crystal	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	10101-97-0	  		  	
	MCS, monohydrate, free acid	  	R	  		  	s	  	1	  	200	  	gr	  	no value	  	0.44	  	no value	  	145224-94-8	  		  	
	HCPCS, minimum 99.5%	  	R	  		  	s	  	1	  	250	  	gr	  	no value	  	0.55	  	no value	  	7365-45-9	  		  	
	Sucrose	  	R	  		  	s	  	3	  	1	  	kg	  	no value	  	6.60	  	no value	  	57-50-1	  		  	
	LB Broth, Lennox	  	R	  		  	s	  	9	  	500	  	gr	  	no value	  	9.92	  	no value	  		  		  	
	Lippolysacchar des from Pseudomonasaeruginosa	  	R	  		  	s	  	3	  	5	  	mg	  	no value	  	0.00	  	no value	  		  		  	
	Iron(III) chloride hexahrdrate	  	R	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	10025-77-1	  		  	
	Imidazole	  	R	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	288-32-4	  		  	
	Imidazole hydrochloride	  	R	  		  	s	  	2	  	500	  	gr	  	no value	  	2.20	  	no value	  	1467-16-9	  		  	
	I-PCR insect cell protein extract on reagent	  	R	  		  	l	  	1	  	250	  	ml	  	0.07	  	no value	  	no value	  		  		  	
	Hexadecyltrlmethylammoniumbromine	  	R	  		  	s	  	2	  	250	  	gr	  	no value	  	1.10	  	no value	  	57-09-0	  		  	

																									
	Visterra Hazardous Chemical Inventory	  	As of Dec. 2014
	 Chemical Name
	  	Laboratory	  	CZ	  	s’ ‘l’
‘g’	  	Quant	  	Vol/
Mass	  	UOM	  	Gal	  	Lbs	  	Ft1	  	CAS	  	Peroxide
Former	  	Notes
	BB Detergent 30% Solution	  	R	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  		  		  	
	CSM-TRP-URA	  	R	  		  	s	  	2	  	10	  	gr	  	no value	  	0.04	  	no value	  	95057-844	  		  	
	CSM-LCU-URA	  	R	  		  	s	  	l	  	10	  	gr	  	no value	  	0.02	  	no value	  	4520-512	  		  	
	CSM-URA	  	R	  		  	s	  	1	  	10	  	gr	  	no value	  	0.02	  	no value	  	4520212	  		  	
	Urea	  	R	  		  	s	  	1	  	25	  	kg	  	no value	  	5.50	  	no value	  	4511-212	  		  	
	YNB with ammonium sulfate	  	R	  		  	s	  	1	  	227	  	gr	  	no value	  	0.50	  	no value	  	57-13-6	  		  	
	DOB	  	R	  		  	s	  	1	  	227	  	gr	  	no value	  	0.50	  	no value	  	4027-512	  		  	
	DOBA	  	R	  		  	s	  	2	  	454	  	gr	  	no value	  	2.00	  	no value	  	4025-012	  		  	
	Teition X-100 Solution	  	R	  		  	l	  	1	  	100	  	ml	  	no value	  	no value	  	no value	  	4026-022	  		  	
	Polyethyleneimine	  	R	  		  	s	  	2	  	2	  	gr	  	no value	  	0.01	  	no value	  	9002-93-1	  		  	
	Terrific broth powder	  	R	  		  	s	  	1	  	500	  	kg	  	no value	  	1.10	  	no value	  		  		  	
	Tris hydrochloride	  	R	  		  	s	  	1	  	1	  	Kg	  	no value	  	2.20	  	no value	  	1185-53-1	  		  	
	Valproic acid sodium salt	  	R	  		  	s	  	1	  	10	  	gr	  	no value	  	0.02	  	no value	  	1069-66-5	  		  	
	TWEEN 20	  	R	  		  	l	  	2	  	500	  	ml	  	0	  	no value	  	no value	  		  		  	
	Tris Acetate	  	R	  		  	s	  	3	  	100	  	gr	  	no value	  	0.66	  	no value	  	9005-64-5	  		  	
	Boric Acid	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	6850-28-8	  		  	
	Terrific broth powder	  	R	  		  	s	  	6	  	500	  	gr	  	no value	  	6.61	  	no value	  	10043-35-3	  		  	
	Sodium Phosphate Dibasic Anhydrous	  	R	  		  	s	  	2	  	1	  	kg	  	no value	  	4.40	  	no value	  	73049-73-7	  		  	
	Sodium Borate Decahydrate	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	2.20	  	no value	  	7558-79-4	  		  	
	Sodium Phosphate dodecanydrate	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	1303-96-4	  		  	
	Sodium Phosphate monobasic monohydrate	  	R	  		  	s	  	1	  	1	  	kg	  	no value	  	2.20	  	no value	  	10101-89-8	  		  	
	Sodium phosphate dibasic dihydrate	  	R	  		  	s	  	1	  	1	  	kg	  	no value	  	2.20	  	no value	  	10049-21-5	  		  	
	Sodium Acetate trihydrate	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	10028-24-7	  		  	
	Sodium carbonate anhydrous	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	6131-90-4	  		  	
	Sodium bicarbonate	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	497-19-8	  		  	
	Sodium Azide	  	R	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	144-55-8	  		  	
	Sodium Nitrate	  	R	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	26628-22-8	  		  	
	Sodium bicarbonate 99.5%	  	R	  		  	s	  	1	  	5	  	kg	  	no value	  	2.20	  	no value	  	7632-00-0	  		  	5.1
	Sodium Carbonate	  	R	  		  	s	  	2	  	1	  	gr	  	no value	  	2.20	  	no value	  	144-55-8	  		  	
	Agarose	  	R	  		  	s	  	3	  	500	  	gr	  	no value	  	0.66	  	no value	  	22232-1	  		  	
	Sodium carbonate monohydrate	  	R	  		  	s	  	1	  	100	  	gr	  	no value	  	1.10	  	no value	  	9012-36-6	  		  	
	Sodium butyrate	  	R	  		  	s	  	2	  	500	  	kg	  	no value	  	0.44	  	no value	  	05968-11-6	  		  	
	Sodium citrate dehydrate	  	R	  		  	s	  	1	  	100	  	kg	  	no value	  	2.20	  	no value	  	156-54-7	  		  	
	Saponin	  	R	  		  	s	  	1	  	1	  	gr	  	no value	  	0.11	  	no value	  	6132-4-3	  		  	
	Sodium Acetate	  	R	  		  	s	  	1	  	50	  	gr	  	no value	  	2.20	  	no value	  	8047-15-2	  		  	
	Citric Acid anhydrous	  	R	  		  	s	  	1	  	1	  	gr	  	no value	  	1.10	  	no value	  	127-09-3	  		  	
	Glycine	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	77-92-9	  		  	
	Glycine hydrochloride	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	56-40-6	  		  	

																									
	Visterra Hazardous Chemical Inventory	  	As of Dec. 2014
	 Chemical Name
	  	Laboratory	  	CZ	  	s’ ‘l’
‘g’	  	Quant	  	Vol/
Mass	  	UOM	  	Gal	  	Lbs	  	Ft1	  	CAS	  	Peroxide
Former	  	Notes
	Glycerol	  	R	  		  	1	  	2	  	1	  		  	0.53	  	no value	  	no value	  	6000-43-7	  		  	
	Guanidine hydrochloride	  	R	  		  	s	  	1	  	2	  	kg	  	no value	  	4.40	  	no value	  	56-81-5	  		  	
	Glycotin	  	R	  		  	l	  	1	  	500	  	ml	  	0.13	  	no value	  	no value	  	50-01-1	  		  	
	Clhylenediamine tetracetic acid, disodium salt dioydrate	  	R	  		  	s	  	3	  	500	  	gr	  	no value	  	3.31	  	no value	  	56-81-5	  		  	
	Glycerol, ultra pure	  	R	  		  	l	  	1	  	1	  	l	  	0.26	  	no value	  	no value	  	6381-92-6	  		  	
	Deoxyribonucleic acid from herring	  	R	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	17372-87-1	  		  	
	Deokycholic acid, sodium salt	  	R	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	302-95-4	  		  	
	D-(+)-Gluconic acid, ortho-lactose	  	R	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	100403-24-5	  		  	
	D-Gluconic acid sodium salt	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	302-95-4	  		  	
	D )-) Tethalose dihydinte	  	R	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	90-80-2	  		  	
	Glycinehydrochloride	  	R	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	527-07-1	  		  	
	D (-) Glucose	  	R	  		  	s	  	1	  	1	  	kg	  	no value	  	2.20	  	no value	  	6138-23-4	  		  	
	Filter agent, Ceiite	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	227-841-8	  		  	
	Cellulose micro crystalline	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	50-99-7	  		  	
	Ammonium Bicarbonate	  	R	  		  	s	  	2	  	500	  	gr	  	no value	  	2.20	  	no value	  	61790-53-2	  		  	
	19344 LB Agar, Vegitone	  	R	  		  	s	  	2	  	500	  	gr	  	no value	  	2.20	  	no value	  	9004-36-6	  		  	
	Bromoscreso Purple	  	R	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	1066-33-7	  		  	
	Ammonium Formate	  	R	  		  	s	  	1	  	50	  	gr	  	no value	  	0.11	  	no value	  	540-69-2	  		  	
	Ammonium Trifiuoroacctic	  	R	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	62625-30-3	  		  	
	Ammonium Formate	  	R	  		  	s	  	1	  	250	  	gr	  	no value	  	0.55	  	no value	  	540-69-2	  		  	
	L-(+)-Arabinose	  	R	  		  	s	  	1	  	50	  	gr	  	no value	  	0.11	  	no value	  	5328-37-0	  		  	
	Ammonium sulfamate	  	R	  		  	s	  	2	  	100	  	gr	  	no value	  	0.44	  	no value	  	540-69-1	  		  	
	Crystal violet	  	R	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	548-62-9	  		  	
	Bromophenoibue blue sodium salt	  	R	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	7773-6-9	  		  	
	BIS-TRIS propane	  	R	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	548-62-9	  		  	
	Chitosan	  	R	  		  	s	  	1	  	50	  	gr	  	no value	  	0.11	  	no value	  	9012-76-4	  		  	
	Casein Acid hydrosate	  	R	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	64431-96-5	  		  	
	Aquacide II	  	R	  		  	s	  	1	  	1	  	kg	  	no value	  	2.20	  	no value	  		  		  	
	Ammonium Chloride	  	R	  		  	s	  	3	  	500	  	gr	  	no value	  	3.31	  	no value	  	12125-02-9	  		  	
	Coomassie Brilliant Blue	  	R	  		  	s	  	1	  	50	  	gr	  	no value	  	0.11	  	no value	  	6104-58-1	  		  	
	Agarose	  	R	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	9012-36-6	  		  	
	Sodium hydroxide	  	R	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	1310-73-2	  		  	
	Tris base	  	R	  		  	s	  	1	  	5	  	kg	  	no value	  	11.00	  	no value	  	77-86-1	  		  	
	Silica gel	  	R	  		  	s	  	1	  	5	  	kg	  	no value	  	11.00	  	no value	  	112926-00-8	  		  	
	Sodium chloride	  	R	  		  	s	  	1	  	5	  	kg	  	no value	  	11.00	  	no value	  	7647-L4-5	  		  	
	Bleach	  	R	  		  	l	  	2	  	3.78	  	L	  	2.00	  	no value	  	no value	  	7681-52-9	  		  	
	N-hydroxysuccinimide	  	L	  		  	s	  	1	  	250	  	gr	  	no value	  	0.55	  	no value	  	6066-82-6	  		  	
	Sodium cyanoborohydride	  	L	  		  	s	  	2	  	5	  	gr	  	no value	  	0.02	  	no value	  	16940-66-2	  		  	

																									
	Visterra Hazardous Chemical Inventory	  	As of Dec. 2014
	 Chemical Name
	  	Laboratory	  	CZ	  	s’ ‘l’
‘g’	  	Quant	  	Vol/
Mass	  	UOM	  	Gal	  	Lbs	  	Ft1	  	CAS	  	Peroxide
Former	  	Notes
	1-(3-dimethyaminopropyl)-3-ethylcarbodiimide HCL	  	L	  		  	s	  	1	  	250	  	gr	  	no value	  	0.55	  	no value	  	25952-53-8	  		  	
	4-Dimethylaminooyridine	  	L	  		  	s	  	2	  	500	  	gr	  	no value	  	2.20	  	no value	  	1122-58-3	  		  	
	N-hydroxysuccinimide	  	L	  		  	s	  	2	  	25	  	gr	  	no value	  	0.11	  	no value	  	6066-82-6	  		  	
	1-hydroxybenzootriazole hydrate	  	L	  		  	s	  	2	  	25	  	gr	  	no value	  	0.11	  	no value	  	123333-53-9	  		  	
	1,3-dicyclohexylcarbodiimide in DCM	  	L	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	538-75-0	  		  	
	Pyridine trifouroacetate	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	464-05-1	  		  	
	Iodine	  	L	  		  	s	  	1	  	50	  	gr	  	no value	  	0.11	  	no value	  	7553-56-2	  		  	
	OPA	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  		  		  	
	3-phenylohenol	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	580-51-8	  		  	
	ninhydran	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	7553-56-2	  		  	
	carbazoie	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	86-74-8	  		  	
	aniline	  	L	  		  	l	  	1	  	5	  	ml	  	0.00	  	no value	  	no value	  	62-53-3	  		  	
	2-phenylphenol	  	L	  		  	s	  	1	  	250	  	gr	  	no value	  	0.55	  	no value	  	485-47-2	  		  	
	3-methyl-2-benzothiazolinone	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	86-74-8	  		  	
	4-benzyloxybenzoldhyde	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	62-53-3	  		  	
	benzonosuifonyl azide	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	90-43-7	  		  	
	Iodomethane	  	L	  		  	l	  	1	  	50	  	ml	  	0.01	  	no value	  	no value	  	149022-15-1	  		  	
	0,2-propynyinydroxylamine	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	21663-79-6	  		  	
	2,5-dihydroxy benzoic acid	  	L	  		  	s	  	1	  	10	  	mg	  	no value	  	0.00	  	no value	  	490-79-9	  		  	
	O-benzylhydroxylamine hydrochloride	  	L	  		  	s	  	2	  	5	  	gr	  	no value	  	0.02	  	no value	  	2687-43-6	  		  	
	3,5-diaminobenzoic acid	  	L	  		  	s	  	1	  	50	  	gr	  	no value	  	0.11	  	no value	  	535-87-5	  		  	
	pentaflourobenzyl hydroxylamine hydrochloride	  	L	  		  	s	  	1	  	250	  	mg	  	no value	  	0.00	  	no value	  	57981-02-9	  		  	
	methoxyamine hydrochloride	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	593-56-6	  		  	
	2-amino-5-metoxy benzoic acid	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	6705-03-9	  		  	
	2,5-dihydroxy benzoic acid	  	L	  		  	s	  	1	  	25	  	mg	  	no value	  	0.00	  	no value	  	490-79-9	  		  	
	hydroxylamine hydrochloride	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	5470-11-1	  		  	
	Sodium hydroxide	  	L	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	1310-73-2	  		  	
	10M Sodium hydroxide	  	L	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	1310-73-2	  		  	
	Potassium hydroxide	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	1310-58-3	  		  	
	Ammonium hydroxide	  	L	  		  	l	  	2	  	250	  	ml	  	0.13	  	no value	  	no value	  	1336-21-6	  		  	
	tetrabutyl ammonium hydroxide	  	L	  		  	1	  	1	  	25	  	ml	  	0.01	  	no value	  	no value	  	2052-49-5	  		  	
	Potassium butoxide	  	L	  		  	l	  	2	  	50	  	ml	  	0.03	  	no value	  	no value	  	865-47-4	  		  	
	5M sodium hydroxide in water	  	L	  		  	l	  	1	  	800	  	ml	  	0.21	  	no value	  	no value	  	1310-73-2	  		  	
	octylamine	  	L	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	111-86-4	  		  	
	triflouroacetic acid	  	L	  		  	l	  	2	  	100	  	ml	  	0.05	  	no value	  	no value	  	76-05-1	  		  	
	triflouroacetic acid	  	L	  		  	l	  	2	  	250	  	ml	  	0.13	  	no value	  	no value	  	76-05-1	  		  	

																									
	Visterra Hazardous Chemical Inventory	  	As of Dec. 2014
	 Chemical Name
	  	Laboratory	  	CZ	  	s’ ‘l’
‘g’	  	Quant	  	Vol/
Mass	  	UOM	  	Gal	  	Lbs	  	Ft1	  	CAS	  	Peroxide
Former	  	Notes
	Sulfuric acid	  	L	  		  	l	  	1	  	500	  	ml	  	0.13	  	no value	  	no value	  	7664-93-9	  		  	
	Acetic acid	  	L	  		  	l	  	1	  	2.5	  	L	  	0.66	  	no value	  	no value	  	64-19-7	  		  	
	5M Hydrochloric acid	  	L	  		  	l	  	1	  	4	  	L	  	1.06	  	no value	  	no value	  	7647-01-0	  		  	
	Water W/Formic acid	  	L	  		  	l	  	1	  	4	  	L	  	1.06	  	no value	  	no value	  		  		  	
	Phosphoric acid	  	L	  		  	l	  	2	  	1	  	L	  	0.53	  	no value	  	no value	  	7664-38-2	  		  	
	Concentrated Hydrochloric acid	  	L	  		  	l	  	4	  	250	  	m	  	0.26	  	no value	  	no value	  	7647-01-0	  		  	
	2M hydrochloric acid	  	L	  		  	l	  	1	  	4	  	L	  	1.06	  	no value	  	no value	  	7647-01-0	  		  	
	Methanesulfonyl chloride	  	L	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	124-63-0	  		  	
	Trimethylncetyl chloride	  	L	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	3282-30-2	  		  	
	Benzoyl chloride	  	L	  		  	l	  	1	  	250	  	ml	  	0.07	  	no value	  	no value	  	98-88-4	  		  	
	Phenolmalonic acid	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	2613-89-0	  		  	
	1.4 cyclohexane dicarboxylic acid	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	1076-97-7	  		  	
	Dimethylmalonic acid	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	595-46-0	  		  	
	Tetra acid	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	1703-58-8	  		  	
	Dimethylmalonic acid	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	210-20-3	  		  	
	Perflourononamoic acid	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	375-95-1	  		  	
	Cyclobutane 1-dicarboxilic acid	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	2613-89-0	  		  	
	3.5 difluoro-4-hydroxybenzaldehyde	  	L	  		  	s	  	1	  	250	  	mg	  	no value	  	0.00	  	no value	  		  		  	
	2.5 difluoro-4-hydroxybenzaldehyde	  	L	  		  	s	  	1	  	250	  	mg	  	no value	  	0.00	  	no value	  		  		  	
	3-fluoro-4-hydroxybenzaldehyde	  	L	  		  	s	  	1	  	250	  	mg	  	no value	  	0.00	  	no value	  		  		  	
	3-fluoro-4hydroxy-5-nitrobenzaldehyde	  	L	  		  	s	  	1	  	250	  	mg	  	no value	  	0.00	  	no value	  		  		  	
	3-fluoro-4-hydroxybenzaldehyde	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  		  		  	
	2.3 dibromo-4-hydroxy-5-methoxybenzaldehyde	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	117238-61-6	  		  	
	3-fluoro-4-hydroxybenzaldehyde	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  		  		  	
	2.5 difluoro-4-hydroxybenzaldehyde	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  		  		  	
	4-hydroxy benzoic acid	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	99-96-7	  		  	
	1-amino purine	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	452-06-2	  		  	
	1-adamantanamine	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	80789-67-9	  		  	
	1-Naonthalene Methylamine	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	118-31-0	  		  	
	Dithiothreitol	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	3483-12-3	  		  	
	3-malemidoproaionic acid	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	55750-62-4	  		  	
	L-cysteine	  	L	  		  	s	  	2	  	25	  	gr	  	no value	  	0.11	  	no value	  	52-90-4	  		  	
	Oxylylene dibromate	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	91-13-4	  		  	
	1,3,5-trio(bromomethyl)benzene	  	L	  		  	s	  	2	  	5	  	gr	  	no value	  	0.02	  	no value	  	18226-42-1	  		  	
	M-xylylene dibromide	  	L	  		  	s	  	1	  	10	  	gr	  	no value	  	0.02	  	no value	  	626-15-3	  		  	
	P-xylylene dibromate	  	L	  		  	s	  	1	  	10	  	gr	  	no value	  	0.02	  	no value	  	3483-12-3	  		  	

																									
	Visterra Hazardous Chemical Inventory	  	As of Dec. 2014
	 Chemical Name
	  	Laboratory	  	CZ	  	s’ ‘l’
‘g’	  	Quant	  	Vol/
Mass	  	UOM	  	Gal	  	Lbs	  	Ft1	  	CAS	  	Peroxide
Former	  	Notes
	1,7 diamine heptane	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	646-19-5	  		  	
	Methoxy pegamine	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	80506-64-5	  		  	
	P-toloinesofonylchloride	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	98-59-9	  		  	
	0-2-(6-oxotaproxylamino)ethyl, O-methylpolyethylene glycol	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  		  		  	
	B-anilino-1-naonthaienesolfonic acid ammonium salt	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	28836-03-5	  		  	
	Spermine	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	71-44-3	  		  	
	Tetrabutyl ammonium bromide	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.01	  	no value	  	1643-19-2	  		  	
	Sodium periodate	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	7790-28-5	  		  	
	Etrahydro-2n-oyran-2-ol	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	6723-30-4	  		  	
	Maleimide	  	L	  		  	s	  	1	  	2	  	gr	  	no value	  	0.00	  	no value	  	641-59-3	  		  	
	N-ethlmaleimide	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	128-53-0	  		  	
	Cystamine dihydrochloride	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	56-17-7	  		  	
	Octadecylanine	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	124-30-1	  		  	
	6-staylactose sodium salt	  	L	  		  	s	  	1	  	0.1	  	gr	  	no value	  	0.00	  	no value	  	74609-39-5	  		  	
	PAMAM OH Dendrimer	  	L	  		  	l	  	1	  	5	  	ml	  	0.00	  	no value	  	no value	  		  		  	
	M-xylylentediarnine	  	L	  		  	l	  	1	  	5	  	ml	  	0.00	  	no value	  	no value	  	1477-55-0	  		  	
	1,8-dibromo octane	  	L	  		  	l	  	1	  	5	  	ml	  	0.00	  	no value	  	no value	  	4549-32-0	  		  	
	N,N-dimethylethylene diamine	  	L	  		  	l	  	1	  	5	  	ml	  	0.00	  	no value	  	no value	  	108-00-9	  		  	
	Benzaldehyde	  	L	  		  	l	  	1	  	2	  	ml	  	0.00	  	no value	  	no value	  	100-52-7	  		  	
	Hemoglobin from bovine blood	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	9008-02-0	  		  	
	Sodium trinceoxyborohydrade	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	56553-60-7	  		  	
	Chloroform-D	  	L	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	865-49-6	  		  	
	L-ascorbic acid sodium salt	  	L	  		  	s	  	2	  	100	  	gr	  	no value	  	0.44	  	no value	  	134-03-2	  		  	
	Glutamic acid	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	110-94-1	  		  	
	Methylmalonic acid	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	516-05-2	  		  	
	2-hydroxy-5-nitrobenzaldehyde	  	L	  		  	s	  	1	  	2	  	gr	  	no value	  	0.00	  	no value	  	97-51-8	  		  	
	10-camphorsulfonic acid	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	35963-20-3	  		  	
	benzoic acid	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.00	  	no value	  	65-85-0	  		  	
	2-sulfobenzaldehyde	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	1008-72-6	  		  	
	G aminibexanoic acid	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	60-32-2	  		  	
	hexylamine	  	L	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	111-26-2	  		  	
	D-glucosamine	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	66-84-2	  		  	
	mono-methyl glutamate	  	L	  		  	l	  	1	  	5	  	ml	  	0.00	  	no value	  	no value	  	1501-27-5	  		  	
	4, 7, 10 Troxa 1, 13, todecanediamine	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	110-94-1	  		  	
	N boc 1,G diaminohexane hydrochloride	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	65915-94-8	  		  	
	D-glucuronic acid	  	L	  		  	s	  	1	  	10	  	gr	  	no value	  	0.02	  	no value	  	6556-12-3	  		  	

																									
	Visterra Hazardous Chemical Inventory	  	As of Dec. 2014
	 Chemical Name
	  	Laboratory	  	CZ	  	s’ ‘l’
‘g’	  	Quant	  	Vol/
Mass	  	UOM	  	Gal	  	Lbs	  	Ft1	  	CAS	  	Peroxide
Former	  	Notes
	undecanol	  	L	  		  	l	  	1	  	25	  	ml	  	0.01	  	no value	  	no value	  	112-42-5	  		  	
	nuccinic acid	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	110-15-6	  		  	
	hyaluronic acid sodium salt	  	L	  		  	s	  	1	  	10	  	gr	  	no value	  	0.02	  	no value	  	9067-32-7	  		  	
	D galactoronic acid sodium salt	  	L	  		  	s	  	2	  	5	  	gr	  	no value	  	0.02	  	no value	  	14984-39-5	  		  	
	levulinic acid	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	123-76-2	  		  	
	B-proplolactone grade 2	  	L	  		  	l	  	1	  	5	  	ml	  	0.00	  	no value	  	no value	  	57-57-8	  		  	
	2-aminobenzamide	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	1501-27-5	  		  	
	2-amino(oxyethylamine) dihydrochloride	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	42-46-519	  		  	
	succinic anhydride	  	L	  		  	s	  	1	  	250	  	gr	  	no value	  	0.55	  	no value	  	659-15-948	  		  	
	glyoxilic acid monohydrate	  	L	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	563-96-2	  		  	
	Chondroitin sulphate	  	L	  		  	s	  	1	  	10	  	gr	  	no value	  	0.02	  	no value	  	39455-18-0	  		  	
	benzyl bromide	  	L	  		  	s	  	1	  	50	  	gr	  	no value	  	0.11	  	no value	  	110-15-6	  		  	
	poly-guluronic acid	  	L	  		  	s	  	1	  	10	  	gr	  	no value	  	0.02	  	no value	  	9005-32-7	  		  	
	Silica gel	  	L	  		  	s	  	1	  	1	  	kg	  	no value	  	2.20	  	no value	  	112926-00-8	  		  	
	Boric acid	  	L	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	10043-35-3	  		  	
	TWEEN 20	  	L	  		  	l	  	2	  	500	  	ml	  	0.26	  	no value	  	no value	  	9005-64-5	  		  	
	D (+) Glucose	  	L	  		  	s	  	1	  	1	  	kg	  	no value	  	2.20	  	no value	  	88-68-6	  		  	
	Citric Acid monohydrate	  	L	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  	5949-29-1	  		  	
	Peptone	  	L	  		  	s	  	2	  	100	  	gr	  	no value	  	0.44	  	no value	  	91079-38-8	  		  	
	sorbital	  	L	  		  	s	  	1	  	1	  	kg	  	no value	  	2.20	  	no value	  	50-70-4	  		  	
	Sodium bicarbonate 99.5%	  	R	  		  	s	  	1	  	2.5	  	kg	  	no value	  	5.50	  	no value	  	144-55-8	  		  	
	Chloroquine diphosphate salt	  	R	  		  	s	  	1	  	50	  	gr	  	no value	  	0.11	  	no value	  	50-63-5	  		  	
	tryptic soy broth	  	B2	  		  	s	  	1	  	500	  	gr	  	no value	  	1.10	  	no value	  		  		  	
	nicotinic acid	  	B2	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	59-67-6	  		  	
	thiamine hydrochloride	  	B2	  		  	s	  	1	  	25	  	gr	  	no value	  	0.06	  	no value	  	67-03-8	  		  	
	dimethyl sulfoxide	  	B2	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	67-68-5	  		  	
	Othylenediaminetetraacetic acid solution	  	B2	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	00-00-4	  		  	
	Adenine hemisulfate salt	  	B2	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	321-30-2	  		  	
	Terrific broth	  	B2	  		  	s	  	7	  	500	  	gr	  	no value	  	7.72	  	no value	  		  		  	
	Ammonium hydroxide	  	L	  		  	l	  	2	  	500	  	ml	  	0.26	  	no value	  	no value	  	1336-21-6	  		  	
	Ammonia solution	  	L	  		  	l	  	2	  	100	  	ml	  	0.05	  	no value	  	no value	  	1336-21-6	  		  	
	sephacryl S 400 high resolution	  	L	  		  	l	  	1	  	150	  	ml	  	0.04	  	no value	  	no value	  	65545-95-4	  		  	
	Ampicillin sodium salt	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	69-52-3	  		  	
	streptomycin sulfate salt	  	L	  		  	s	  	2	  	25	  	gr	  	no value	  	0.11	  	no value	  	3810-74-0	  		  	
	liquefied phenol	  	L	  		  	l	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	59-67-6	  		  	
	D-pantothenic acid hemicalcium salt	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	67-03-8	  		  	
	Ampicillin sodium salt	  	L	  		  	s	  	2	  	25	  	gr	  	no value	  	0.11	  	no value	  	69-52-3	  		  	
	a-Amylae from Aspergillus oryzae	  	L	  		  	s	  	1	  	10	  	gr	  	no value	  	0.02	  	no value	  	9001-19-8	  		  	

																									
	Visterra Hazardous Chemical Inventory	  	As of Dec. 2014
	 Chemical Name
	  	Laboratory	  	CZ	  	s’ ‘l’
‘g’	  	Quant	  	Vol/
Mass	  	UOM	  	Gal	  	Lbs	  	Ft1	  	CAS	  	Peroxide
Former	  	Notes
	Dextralip 50	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	9011-18-1	  		  	
	oiphofiomacin	  	L	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	85721-33-1	  		  	
	fetuin, from fetal calf serum	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	9014-81-7	  		  	
	chlorhexidine	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	55-56-1	  		  	
	colistin sulfate salt	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	1264-72-8	  		  	
	biotin	  	L	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	58-85-5	  		  	
	tetracycline hydrate	  	L	  		  	s	  	1	  	100	  	gr	  	no value	  	0.22	  	no value	  	30583-60-7	  		  	
	Guanidine hydrochloride	  	L	  		  	s	  	1	  	10	  	gr	  	no value	  	0.02	  	no value	  	50-01-1	  		  	
	dimethyl sulfoxide	  	L	  		  	l	  	3	  	100	  	ml	  	0.08	  	no value	  	no value	  	67-68-5	  		  	
	2-caroxyetnyl acrylate	  	CR	  		  	l	  	1	  	50	  	ml	  	0.01	  	no value	  	no value	  	24615-84-7	  		  	
	biotin	  	CR	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	58-85-5	  		  	
	ethanolamine HCL	  	CR	  		  	l	  	1	  	10.5	  	ml	  	0.00	  	no value	  	no value	  	2002-24-6	  		  	
	1 V-carbonyldiamidazoic	  	CR	  		  	s	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	530-62-1	  		  	
	colistin sulfate salt	  	CR	  		  	s	  	1	  	500	  	mg	  	no value	  	0.00	  	no value	  	1264-72-8	  		  	
	colistin sulfate salt	  	CR	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	1264-72-8	  		  	
	2 hydrazinopyridine	  	CR	  		  	s	  	1	  	1	  	gr	  	no value	  	0.00	  	no value	  	4930-98-7	  		  	
	N-hydroxysuccinamide sodium salt	  	CR	  		  	s	  	2	  	250	  	gr	  	no value	  	1.10	  	no value	  	106627-64-7	  		  	
	proparglymine	  	CR	  		  	l	  	1	  	25	  	ml	  	0.01	  	no value	  	no value	  	2450-71-1	  		  	
	Hematoxylin	  	R	  		  	l	  	1	  	500	  	ml	  	0.13	  	no value	  	no value	  	517-28-2	  		  	
	Eosin	  	R	  		  	l	  	1	  	500	  	ml	  	0.13	  	no value	  	no value	  	15086-94-9	  		  	
	Triethylamine	  	L	  		  	1	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	121-44-8	  		  	
	Sodium borohydride	  	L	  		  	5	  	2	  	25	  	gr	  	no value	  	0.11	  	no value	  	16940-66-2	  		  	
	ethanolamine	  	L	  		  	1	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	14104305	  		  	
	Triethylamine	  	L	  		  	1	  	1	  	1	  	l	  	0.26	  	no value	  	no value	  	121-44-8	  		  	
	PAMAM dendrimer	  	L	  		  	1	  	1	  	2.5	  	ml	  	0.00	  	no value	  	no value	  	163442-67
 -9
	  		  	
	2 mercaptoethanol	  	L	  		  	1	  	2	  	5	  	ml	  	0.00	  	no value	  	no value	  	60-24-2	  		  	
	4-azidoneazoic acid	  	L	  		  	5	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	6427-66-3	  		  	
	ethylenediamine	  	L	  		  	1	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	107-15-3	  		  	
	2 mercaptoethanol	  	R	  		  	1	  	1	  	25	  	ml	  	0.01	  	no value	  	no value	  	60-24-2	  		  	
	Hydrogen chloride in methanol solution	  	L	  		  	1	  	1	  	250	  	ml	  	0.07	  	no value	  	no value	  	132228-87-6	  		  	
	dimethylmalonyl chloride	  	CR	  		  	1	  	1	  	1	  	ml	  	0.00	  	no value	  	no value	  	5659-93-8	  		  	
	4 formylbenzoic acid	  	CR	  		  	5	  	1	  	10	  	gr	  	no value	  	0.02	  	no value	  	619-66-9	  		  	
	propylamine	  	CR	  		  	1	  	1	  	50	  	ml	  	0.01	  	no value	  	no value	  	107-10-8	  		  	
	Colistin sulfate sait	  	CR	  		  	5	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	1264-72-8	  		  	
	tetranitromethane	  	CR	  		  	1	  	1	  	1	  	l	  	0.20	  	no value	  	no value	  	509-14-8	  		  	
	Malonyl chloride	  	CR	  		  	5	  	1	  	5	  	gr	  	no value	  	0.01	  	no value	  	1663-67-8	  		  	
	Hema 3 Fixative	  	R	  		  	1	  	1	  	3.8	  	L	  	1.00	  	no value	  	no value	  		  		  	
	Conflikt	  	R	  		  	1	  	4	  	3.8	  	L	  	4.02	  	no value	  	no value	  		  		  	

																									
	Visterra Hazardous Chemical Inventory	  	As of Dec. 2014
	 Chemical Name
	  	Laboratory	  	CZ	  	s’ ‘l’
‘g’	  	Quant	  	Vol/
Mass	  	UOM	  	Gal	  	Lbs	  	Ft1	  	CAS	  	Peroxide
Former	  	Notes
	Neutrawash	  	R	  		  	1	  	3	  	3.8	  	l	  	3.01	  	no value	  	no value	  		  		  	
	Dichloromethane anhydrous	  	L	  		  	1	  	2	  	100	  	ml	  	0.05	  	no value	  	no value	  	75-09-2	  		  	
	Ethylacetate	  	L	  		  	1	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	141-78-6	  		  	
	T-Butyl alcohol anhydrous	  	L	  		  	1	  	1	  	250	  	ml	  	0.07	  	no value	  	no value	  	75-65-0	  		  	
	N, N-Dimethylacetamide anhydrous	  	L	  		  	1	  	2	  	100	  	ml	  	0.05	  	no value	  	no value	  	127-19-5	  		  	
	1.5-pentanediol	  	L	  		  	1	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	111-29-5	  		  	
	2-Methyl-2-butanol	  	L	  		  	1	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	75-85-4	  		  	
	Benzaldehyde dimethylacetal	  	L	  		  	1	  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	1125-88-8	  		  	
	Diethanolamine	  	L	  		  	1	  	1	  	500	  	ml	  	0.13	  	no value	  	no value	  	111-42-2	  		  	
	Acetonitelle	  	L	  		  	1	  	1	  	1	  	L	  	0.26	  	no value	  	no value	  	75-05-8	  		  	
	Acetone	  	L	  		  	1	  	1	  	1	  	L	  	0.26	  	no value	  	no value	  	67-64-1	  		  	
	Dimethylsulfoxide	  	L	  		  	1	  	1	  	500	  	ml	  	0.13	  	no value	  	no value	  	67-68-5	  		  	
	Chloroform	  	L	  		  	1	  	1	  	500	  	ml	  	0.13	  	no value	  	no value	  	67-66-3	  		  	
	Chloroform	  	L	  		  	1	  	1	  	25	  	ml	  	0.01	  	no value	  	no value	  	67-66-3	  		  	
	Heptane	  	L	  		  		  	1	  	4	  	L	  	1.06	  	no value	  	no value	  	142-82-5	  		  	
	Tetrahydrofuran	  	L	  		  		  	4	  	100	  	ml	  	0.11	  	no value	  	no value	  	109-99-9	  	Y	  	Peroxide
Former
	Tetrahydrofuran	  	L	  		  		  	1	  	1	  	L	  	0.26	  	no value	  	no value	  	109-99-9	  	Y	  	Peroxide
Former
	Tetrahydrofuran	  	L	  		  		  	1	  	4	  	L	  	1.06	  	no value	  	no value	  	109-99-9	  	Y	  	Peroxide
Former
	Propanol	  	L	  		  		  	1	  	1	  	L	  	0.20	  	no value	  	no value	  	71-23-8	  		  	
	Propanol	  	L	  		  		  	1	  	2	  	L	  	0.53	  	no value	  	no value	  	71-23-8	  		  	
	Ethyl acetate	  	L	  		  		  	1	  	4	  	L	  	1.06	  	no value	  	no value	  	141-78-6	  		  	
	Pyridine	  	L	  		  		  	1	  	1	  	L	  	0.26	  	no value	  	no value	  	110-80-1	  		  	
	Propargy alcohol	  	L	  		  		  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	107-19-7	  		  	
	4-Pheny 2-butanone	  	L	  		  		  	1	  	250	  	ml	  	0.07	  	no value	  	no value	  	2550-26-7	  		  	
	Diethyl ether	  	L	  		  		  	1	  	1	  	L	  	0.26	  	no value	  	no value	  	60-29-7	  	Y	  	Peroxide
Former
	Benzyl acetate	  	L	  		  		  	1	  	500	  	ml	  	0.13	  	no value	  	no value	  	140-11-4	  		  	
	Isopropanol	  	L	  		  		  	G	  	1	  	L	  	1.59	  	no value	  	no value	  	67-63-0	  		  	
	Dietyiene glycol	  	L	  		  		  	1	  	500	  	ml	  	0.13	  	no value	  	no value	  	111-46-6	  		  	
	Pyridine	  	L	  		  		  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	110-86-1	  		  	
	Chloroform	  	L	  		  		  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	67-66-3	  		  	
	Methyl sulfoxide	  	L	  		  		  	2	  	100	  	ml	  	0.05	  	no value	  	no value	  	67-68-5	  		  	
	N1N-diisopropycardonimide	  	L	  		  		  	1	  	25	  	ml	  	0.01	  	no value	  	no value	  	693-13-0	  		  	
	1-methyl-2-pyrroiidone	  	L	  		  		  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	872-50-4	  		  	
	N1N-diisopropyiethyiamine	  	L	  		  		  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	7087-68-5	  		  	
	Monoethanolamine	  	L	  		  		  	1	  	500	  	ml	  	0.13	  	no value	  	no value	  	141-43-5	  		  	
	Dimethyl sulfoxide	  	L	  		  		  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	67-68-5	  		  	

																									
	Visterra Hazardous Chemical Inventory	  	As of Dec. 2014
	 Chemical Name
	  	Laboratory	  	CZ	  	s’ ‘l’
‘g’	  	Quant	  	Vol/
Mass	  	UOM	  	Gal	  	Lbs	  	Ft1	  	CAS	  	Peroxide
Former	  	Notes
	Piperidine	  	L	  		  		  	2	  	200	  	ml	  	0.11	  	no value	  	no value	  	110-89-4	  		  	
	N.N. Dimethyl fornamide	  	L	  		  		  	1	  	100	  	ml	  	0.03	  	no value	  	no value	  	68-12-2	  		  	
	Ethanol 200 Proof	  	L	  		  		  	1	  	4	  	L	  	1.06	  	no value	  	no value	  	64-17-5	  		  	
	Ethanol 190 proof	  	L	  		  		  	1	  	4	  	L	  	1.06	  	no value	  	no value	  	64-17-5	  		  	
	2-Propanol	  	L	  		  		  	5	  	4	  	L	  	5.28	  	no value	  	no value	  	67-63-0	  		  	
	Acetonitrile	  	L	  		  		  	6	  	4	  	L	  	6.34	  	no value	  	no value	  	75-05-8	  		  	
	Acetone	  	L	  		  		  	2	  	2	  	L	  	1.06	  	no value	  	no value	  	67-64-1	  		  	
	Methylene chloride	  	L	  		  		  	3	  	4	  	L	  	3.17	  	no value	  	no value	  	75-09-2	  		  	
	Methanol	  	L	  		  		  	4	  	4	  	L	  	4.23	  	no value	  	no value	  	67-56-1	  		  	
	Anhydrous Methanol	  	L	  		  		  	1	  	1	  	L	  	0.26	  	no value	  	no value	  	67-56-1	  		  	
	2-butanone	  	L	  		  		  	1	  	1	  	L	  	0.26	  	no value	  	no value	  	78-93-3	  		  	
	2-Butanol	  	L	  		  		  	2	  	1	  	L	  	0.53	  	no value	  	no value	  	78-92-2	  		  	
	2-Butanol	  	L	  		  		  	2	  	1	  	L	  	0.53	  	no value	  	no value	  	78-92-2	  		  	
	Dioxane	  	L	  		  		  	1	  	500	  	ml	  	0.13	  	no value	  	no value	  	123-91-1	  		  	
	1.2-dicholoroethane	  	L	  		  		  	1	  	500	  	ml	  	0.13	  	no value	  	no value	  	107-06-2	  		  	
	Acetic anhydride	  	L	  		  		  	1	  	200	  	ml	  	0.05	  	no value	  	no value	  	108-24-7	  		  	
	10% buffered formalin phosphate	  	L	  		  		  	2	  	4	  	L	  	2.11	  	no value	  	no value	  		  		  	

 Schedule 1 

Prohibited Hazardous Materials 

The following may not be used or stored on to the premises without prior approval from the Landlord and receipt of any regulatory permits, licenses or
registrations that may be required under any local, state or federal Environmental Health and Safety Laws. 
  

	 	1.	Selected biological agents and toxins (Select Agents) as defined by the Federal Select Agent Program (http://www.selectagents.gov/) which have the potential to pose a severe threat to public, animal or plant
health or to animal or plant products and require registration to possess, use or transfer. Select Agents are regulated under 7CFR Part 331, 9 CFR Part 121 and 42 CFR Part 73. 

 

	 	2.	Chemicals that present a high level of security risk under the April 2007 Department of Homeland Security - Chemical Facilities Anti-Terrorism Standards (CFATS) regulation
(http://www.dhs.gov/identifying-facilities-covered-chemical-security-regulation), that are at or above the applicable Screening Threshold Quantity. 

  

	 	3.	The following chemicals and classes of chemicals: 

  

	 	•	 	Perchloric Acid 

  

	 	•	 	Explosive Materials (require ATF license) 

  

	 	•	 	Organic Peroxide Unclassified Detonable: Organic peroxides that are capable of detonation. These peroxides pose an extremely high explosion hazard through rapid explosive decomposition. 

 

	 	•	 	Organic Peroxide Class 1: Those formulations that are capable of deflagration but not detonation. 

  

	 	•	 	Oxidizer Class 4: An oxidizer that can undergo an explosive reaction due to contamination or exposure to thermal or physical shock. Additionally, the oxidizer will enhance the burning rate and can cause
spontaneous ignition of combustibles. 

  

	 	•	 	Pyrophoric Material: A chemical with an auto ignition temperature in air, at or below a temperature of 130°F (54.4°C). 

 

	 	•	 	Reactive Class 4: Materials that in themselves are readily capable of detonation or explosive decomposition or explosive reaction at normal temperatures and pressures. This class includes materials that are
sensitive to mechanical or localized thermal shock at normal temperatures and pressures. 

  

	 	•	 	Reactive Class 3: Materials that in themselves are capable of detonation or of explosive decomposition or explosive reaction but which require a strong initiating source or which must be heated under confinement
before initiation. This class includes materials that are sensitive to thermal or mechanical shock at elevated temperatures and pressures. 

  

	 	•	 	Water Reactive Class 3: Materials that react explosively with water without requiring heat or confinement. 

  

	 	4.	Radioactive Materials and Devices as regulated in 105 CMR 120 Radiation Control Program. 

 Schedule 2 

Total Allowable Quantities of Hazardous Materials  
  

																													
	 	  	 780 CMR

Table
 307.8(1)
	 	 780 CMR
Table
307.8(1)

Note D
	 	780 CMR
Table
307.8(1)
Note E	 	  	 	 	780 CMR
Table
417.2	 	 	780 CMR
Table 417.2	 	 	 
	 Class
	  	 Baseline

Permitted

Storage
	 	 Adjusted for
100% A.S.
	 	Adjusted for
100%
Cabinets	 	  	Adjusted for
both A.S. &
Cab.	 	% Above or
Below
Grade	 	 	Total
Control
Areas	 	 	NET
STORAGE
PERMITTED
FOR TOTAL
CONTROL
AREAS	 	TENANT
STORAGE
PERMITTED	 	INVENTORY	 	 	 
	 Flammable liquid 1A
	  	30 gallons	 	60	 	 	60	  	  	120	 	 	0.5	  	 	 	2	  	 	120	 	120.00	 	 	0.26	  	 	gallons
	 Flammable liquid 1B
	  	60 gallons	 	120	 	 	120	  	  	240	 	 	0.5	  	 	 	2	  	 	240	 	240.00	 	 	34.62	  	 	gallons
	 Flammable liquid 1C
	  	90 gallons	 	180	 	 	180	  	  	360	 	 	0.5	  	 	 	2	  	 	360	 	360.00	 	 	1.14	  	 	gallons
	 Flammable liquid Combined Class 1
	  	120 gallons	 	240	 	 	240	  	  	480	 	 	0.5	  	 	 	2	  	 	480	 	480.00	 	 	36.04	  	 	gallons
	 Combustible Liquid Class 2
	  	120 gallons	 	240	 	 	240	  	  	480	 	 	0.5	  	 	 	2	  	 	480	 	480.00	 	 	0.15	  	 	gallons
	 Combustible Liquid Class 3A
	  	330 gallons	 	660	 	 	660	  	  	1320	 	 	0.5	  	 	 	2	  	 	1320	 	1320.00	 	 	2.04	  	 	gallons
	 Combustible Liquid Class 3B
	  	13200 gallons	 	No Limit if storage area has automatic sprinkler system(307. 8(1) Note F)	 	 	26400	  	  	No Limit
if storage
area has
automatic
sprinkler
system(307.8
(l) Note
F)	 	 	0.5	  	 	 	2	  	 	No Limit
if storage
area has
automatic
sprinkler
system(307.8(l)
Note F)	 	No Limit
if storage
area has
automatic
sprinkler
system(307.8(1)
Note F)	 	 	1.00	  	 	gallons
	 Flammable Gas (Gaseous and Liquefied)
	  	30 gallons	 	60	 	 	60	  	  	120	 	 	0.5	  	 	 	2	  	 	120	 	120.00	 				 	gallons
		  	 1000 ft3
 at STP
	 	2000	 	 	2000	  	  	4000	 	 	0.5	  	 	 	2	  	 	4000	 	4000.00	 				 	ft3at
STP
	 Flammable Solid
	  	125 lbs	 	250	 	 	250	  	  	500	 	 	0.5	  	 	 	2	  	 	500	 	500.00	 	 	0.44	  	 	lbs

																																	
	 	 	780 CMR
Table
307.8(1)	 	 780 CMR

Table
 307.8(1)

Note D
	 	 780 CMR

Table
 307.8(1)

Note E
	 	 	 	 	780 CMR
Table
417.2	 	 	780 CMR
Table
417.2	 	 	 
	 Organic Peroxide UD
	 	1 lbs	 	Facility must have automatic sprinkler system (307.8(1) Note H)	 	2	 	 	2	  	 	 	0.5	  	 	 	2	  	 	 	2	  	 	 	2.00	  	 				 	lbs
	 Organic Peroxide I
	 	5 lbs	 	10	 	10	 	 	20	  	 	 	0.5	  	 	 	2	  	 	 	20	  	 	 	20.00	  	 				 	lbs
	 Organic Peroxide II
	 	50 lbs	 	100	 	100	 	 	200	  	 	 	0.5	  	 	 	2	  	 	 	200	  	 	 	200.00	  	 				 	lbs
	 Organic Peroxide III
	 	1251bs	 	250	 	250	 	 	500	  	 	 	0.5	  	 	 	2	  	 	 	500	  	 	 	500.00	  	 				 	lbs
	 Oxidizer 4
	 	libs	 	 Facility must have automatic sprinkler system

(307.8(1) Note H)
	 	2	 	 	2	  	 	 	0.5	  	 	 	2	  	 	 	2	  	 	 	2.00	  	 				 	lbs
	 Oxidizer 3
	 	10 lbs	 	20	 	20	 	 	40	  	 	 	0.5	  	 	 	2	  	 	 	40	  	 	 	40.00	  	 				 	lbs
	 Oxidizer 2
	 	250 lbs	 	500	 	500	 	 	1000	  	 	 	0.5	  	 	 	2	  	 	 	1000	  	 	 	1000.00	  	 	 	0.07	  	 	lbs
	 Oxidizer 1
	 	1000 lbs	 	2000	 	2000	 	 	4000	  	 	 	0.5	  	 	 	2	  	 	 	4000	  	 	 	4000.00	  	 				 	lbs
	 Oxidizer Gas
	 	15 gallons	 	30	 	30	 	 	60	  	 	 	0.5	  	 	 	2	  	 	 	60	  	 	 	60.00	  	 				 	gallons
	 (Gaseous or Liquified)
	 	1500 ft3
at STP	 	3000	 	3000	 	 	6000	  	 	 	0.5	  	 	 	2	  	 	 	6000	  	 	 	6000.00	  	 				 	ft3at
STP
	 Cryogenics Flammable or Oxidizing
	 	45 gallons	 	90 gallons	 	Not applicable (780 CMR 307.8(1))	 	 	90	  	 	 	0.5	  	 	 	2	  	 	 	90	  	 	 	90.00	  	 				 	gallons

																											
	 	  	 780 CMR
Table
307.8(1)
	  	780 CMR
Table
307.8(1)
Note D	 	780 CMR
Table
307.8(1)
Note E	  	 	  	780 CMR
Table
417.2	 	  	780 CMR
Table 417.2	 	  	 
	 Pyrophoric Material
	  	4 lbs	  	Facility
 must
have
 automatic

sprinkler
 system

(307.8(1)
 Note H)
	 	8	  	8	  	 	0.5	  	  	 	2	  	  	8	  	8.00	  				  	lbs
	 Unstable Class 4
	  	1 lbs	  	Facility
 must
have
 automatic

sprinkler
 system

(307.8(1)
 Note H)
	 	2	  	2	  	 	0.5	  	  	 	2	  	  	2	  	2.00	  				  	lbs
	 Unstable Class 3
	  	5 lbs	  	10	 	10	  	20	  	 	0.5	  	  	 	2	  	  	20	  	20.00	  				  	lbs
	 Unstable Class 2
	  	50 lbs	  	100	 	100	  	200	  	 	0.5	  	  	 	2	  	  	200	  	200.00	  				  	lbs
	 Unstable Class 1
	  	125 lbs	  	250	 	250	  	500	  	 	0.5	  	  	 	2	  	  	500	  	500.00	  	 	0.33	  	  	lbs
	 Water Reactive Class 3
	  	5 lbs	  	10	 	10	  	20	  	 	0.5	  	  	 	2	  	  	20	  	20.00	  				  	lbs
	 Water Reactive Class 2
	  	50 lbs	  	100	 	100	  	200	  	 	0.5	  	  	 	2	  	  	200	  	200.00	  	 	0.32	  	  	lbs
	 Water Reactive Class 1
	  	No Limit	  	No Limit	 	No Limit	  	No Limit	  	 	0.5	  	  	 	2	  	  	No Limit	  	No Limit	  				  	lbs
								
	 SF

DISTRIBUTION

Visterra
                Total                 Allocation
	  		  				  				  		  		  				  	
	
                11750        
       11750                 1.00
	  		  				  				  		  		  				  	

 Schedule 3 

Laboratory Decommissioning Checklist 

Tenant Laboratory Decommissioning Checklist 
  

 

									
					
	Tenant Name:	  	  
	  		  	Tenant Location:	  	  

 Waste Management 
 If
you used and/or stored the following materials, please put a “Ö” in the “used and/or stored” box. Indicate the disposal vendor and date of final removal from the
laboratory. 
  

							
	 Item
	  	Used and/or Stored	  	Disposal Vendor Name	  	Removal Date
	 Hazardous (Chemical) Waste
	  		  		  	
	 Gas Cylinders
	  		  		  	
	 Biological Waste and Sharps
	  		  		  	
	 Animal Carcasses and Waste
	  		  		  	
	 Radioactive Waste
	  		  		  	
	 Controlled Substances
	  		  		  	
	 Select Agents
	  		  		  	

 Permits and Licenses 

If you possessed any of the following permits and/or licenses, please put a “Ö” in the
“Applicable” box. Indicate the date you requested termination of the permit or license, and whether confirmation has been received from the regulatory agency. 
  

											
	 Permit or License
	  	Regulatory Agency	 	  	Applicable?	  	Date of
Termination
Request	  	Confirmation
from
Regulator
Received?
	 Recombinant DNA
	  	 	City of Cambridge	  	  		  		  	

 Please return this form to the DivcoWest Office, Attention: Michael Fitzgerald 

									
	 Permit
	  		  		  		  	
	 Biosafety Permit
	  	City of Cambridge	  		  		  	
	 Laboratory Animal Use Permit
	  	City of Cambridge	  		  		  	
	 Flammables Permit
	  	City of Cambridge	  		  		  	
	 Wastewater Discharge Permit
	  	Massachusetts Water Resources Authority	  		  		  	
	 Hazardous Waste Generator ID#
	  	Massachusetts Department of Environmental Protection	  		  		  	
	 Radiation Control License
	  	Massachusetts Department of Public Health	  		  		  	
	 Controlled Substances Registration
	  	Massachusetts Department of Public Health & United States Drug Enforcement Agency	  		  		  	
	 Select Agent Registration
	  	United States / Department of Agriculture or Homeland Security	  		  		  	

 Laboratory Decontamination Survey 
  

					
	Were all fixed surfaces in the laboratory such as benches, fume hoods, sinks, cold rooms and warm rooms decontaminated with a disinfectant or other efficacious decontaminant?	  	YES	  	NO
			
	If “YES”, briefly describe the decontaminants used, specific to the hazardous materials in use and storage in the laboratory.	  		  	
			
	Did you use any mercury-containing equipment such as thermometers, or elemental mercury?	  	YES	  	NO
			
	If “YES”, briefly describe:	  		  	
			
	If “YES”, have you had the sink traps tested for mercury contamination? If “YES”, attach results.	  	YES	  	NO
			
	If the results of the mercury test indicated the presence of mercury, did you have it removed and decontaminated? If “YES”, attach documentation.	  	YES	  	NO

 Please return this form to the DivcoWest Office, Attention: Michael Fitzgerald 

					
	Did you use any perchlorates in the chemical fume hoods?	  	YES	  	NO
			
	If “YES”, indicate the location of the fume hood(s):	  		  	
			
	If “YES”, have you had the fume hood(s) tested for perchlorate residues? If “YES”, attach results.	  	YES	  	NO
			
	If the results of the perchlorate test indicated the presence of residues, did you have the fume hood and associated ductwork decontaminated? If “YES”, attach documentation.	  	YES	  	NO
			
	Is there any equipment remaining in the laboratory that will not be removed, such as but not limited to biosafety cabinets, incubators, or freezers?	  	YES	  	NO
			
	If “YES”, briefly describe the equipment and the methods used to decontaminate the equipment:	  		  	
			
	During the lease period, was there ever a chemical spill in the laboratory?	  	YES	  	NO
			
	If “YES”, please provide information on the material and quantity involved in the spill, and approximate date of the spill:	  		  	

  

			
		
	Print Name of Person Completing This Form:
                                         
                                	 	
		
	Print Name of Company Officer:
                                         
                                         
           	 	
		
	Signature of Company Officer:
                                         
                                         
              	 	
		
	                                      
            Date:                            
                    	 	

 Please return this form to the DivcoWest Office, Attention: Michael Fitzgerald 

 SECOND AMENDMENT OF LEASE 

THIS SECOND AMENDMENT OF LEASE (this “Amendment”) is made as of this
28lh day of May, 2015, by and between DWF IV ONE KENDALL, LLC, a Delaware limited liability company having an address c/o Divco West Real Estate Services, Inc., One Kendall Square,
Cambridge, MA 02139, Attention: Property Manager (“Landlord”) and VISTERRA, INC., a Delaware corporation having a mailing address at One Kendall Square, Building 300, Cambridge, Massachusetts 02139
(“Tenant”). 
 BACKGROUND: 

A. Reference is made to an Indenture of Lease dated September 2, 2010, by and between RB Kendall Fee, LLC, as landlord, and Tenant (the
“Original Lease”), as amended by that certain First Amendment of Lease dated as of January 31, 2015 (the “First Amendment;” the Original Lease, as so amended by the First Amendment, the
“Lease”), demising approximately 11,750 rentable square feet of space on the third floor of Building 300 (the “Existing Premises”) in One Kendall Square, Cambridge, Massachusetts (the
“Complex”). Capitalized terms used, but not defined herein shall have the same meaning as in the Lease. 
 B.
Landlord is the successor to RB Kendall Fee, LLC, and Landlord and Tenant are the current holders, respectively, of the lessor’s and lessee’s interests in the Lease. 

C. The parties desire to (i) add to the Existing Premises an additional approximately 2,729 rentable square feet of space on the second
floor of Building 300 in the Complex, and (ii) amend the Lease in certain other respects, all as hereinafter set forth. 

AGREEMENTS: 
 NOW,
THEREFORE, in consideration of the mutual covenants and agreements herein contained, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree to amend the Lease as
follows: 
 1. Inclusion of Expansion Premises; Expansion Premises Term. Effective as of June 15, 2015 (the
“Expansion Premises Commencement Date”), there shall be added to the Premises under the Lease the approximately 2,729 rentable square feet of space on the second
(2nd) floor of Building No. 300 of the Complex more particularly shown on Exhibit 2C attached hereto as the “Expansion Premises” (the “Expansion
Premises”), which Exhibit 2C shall be deemed to be attached to the Lease as Exhibit 2C. 
 Accordingly, as of the
Expansion Premises Commencement Date: (i) the term “Premises” in Exhibit 1, Sheet 1 shall be amended to state: “An area on the third (3rd) floor of Building No. 300
(the “Existing Premises”), as shown on Exhibit 2 attached hereto and an area on the second (2nd) floor of Building No. 300 (the “Expansion
Premises”), as shown on Exhibit 2C (i) attached hereto;” and (iii) the term “Use of Premises” in Exhibit 1, Sheet 1 shall be amended to state: “(i) Existing Premises: General office and laboratory
use and for no other purposes, subject to the terms and conditions of this Lease; and (ii) Expansion Premises: General office use and for no other purposes, subject to the terms and conditions of this Lease.” 

The Term of the Lease for the Expansion Premises shall be the period beginning on the Expansion Premises Commencement Date and ending on
March 31, 2017 (the “Expansion Premises Term”). Landlord anticipates delivering possession of the Expansion Premises to Tenant on or before 

  
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 June 15, 2015; provided, however, that if Landlord, for any reason whatsoever, cannot deliver possession of
the Expansion Premises to Tenant on or before June 15, 2015, this Amendment shall not be void or voidable, nor shall Landlord be liable for any loss or damage resulting therefrom, but in that event, there shall be no accrual of Yearly Rent
(subject to the provisions hereof) with respect to the Expansion Premises until Landlord delivers possession of the Expansion Premises to Tenant. Tenant’s inability or failure to take possession of the Expansion Premises when delivery is
tendered by Landlord shall not delay the Expansion Premises Commencement Date or Tenant’s obligation to pay Yearly Rent with respect thereto. 

Except for the above-described use of the Expansion Premises and as otherwise provided herein and except to the extent inconsistent herewith,
all terms and provisions of the Lease shall be applicable to Tenant’s leasing of the Expansion Premises. As of the Expansion Premises Commencement Date, the Premises under the Lease shall consist of the Existing Premises and the Expansion
Premises. 
 2. “As-Is” Condition of Expansion Premises. The Expansion Premises shall be leased to Tenant as of, and
Landlord shall deliver possession thereof to Tenant on, the Expansion Premises Commencement Date in its “as is” condition as of the date of this Amendment (provided that the same shall be in broom clean condition and free of all tenants
and/or occupants and their personal property), without any obligation on the part of Landlord to perform any construction therein or to prepare the same for Tenant’s occupancy or otherwise or to pay any allowances therefor, except for
Landlord’s contribution of the Expansion Premises Allowance pursuant to Section 3 below. 
 3. Expansion Premises Allowance;
Additional Term Allowance. So long as Tenant is not in default under the Lease, and no event or condition exists which with the giving of notice and/or the expiration of any grace period would constitute a default under the Lease, Landlord shall
provide to Tenant an amount not to exceed $27,290 (the “Expansion Premises Allowance”) in the aggregate to be applied towards all so-called “hard” and “soft” costs of construction incurred by Tenant after
the date of this Amendment in performing improvements and alterations to the Expansion Premises (collectively, the “Expansion Premises Construction Costs”) and the Existing Premises; provided, however, that no more than
twenty percent (20%) of the Expansion Premises Allowance shall be used for architectural, engineering and other “soft” costs of construction. Disbursements of the Expansion Premises Allowance shall be made by Landlord within thirty
(30) days following Landlord’s receipt of Tenant’s written request, which request shall be accompanied by customary documentation supporting the charges for completion of such improvements and alterations. Such documentation shall be
of a scope and detail sufficient to satisfy a commercial construction lender operating in the market area in which the Building is located and shall include copies of paid invoices and, to the extent applicable, partial lien waivers or full lien
waivers (in the case of the final disbursement). 
 Any alterations and improvements to the Premises by Tenant shall be subject to the
requirements set forth in Article 12 of the Lease. In addition, Tenant’s compliance with Article 12 of the Lease shall be a condition to Landlord’s obligation hereunder to make any disbursement of the Expansion Premises Allowance. Any
portion of the Expansion Premises Allowance that has not been requested by Tenant in writing as a reimbursement on or before November 1, 2015 shall be deemed forfeited by Tenant, and Landlord shall have no further obligation with respect
thereto. 
 In addition, reference is hereby made to the Additional Term Allowance (as defined in the First Amendment). Subject to the
provisions of Section 6 of the First Amendment, Tenant may apply the Additional Term Allowance towards the Expansion Premises Construction Costs. 

4. Payment of Yearly Rent Attributable to Expansion Premises. Throughout the Expansion

  
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Premises Term, in addition to all other amounts due and payable by Tenant under the Lease, Tenant shall pay to Landlord monthly installments of Yearly Rent attributable to the Expansion Premises
as follows and otherwise as set forth in the Yearly Rent payment provisions of the Lease: 
  

					
	 Period
	  	Monthly
Rent	 
	 Expansion Premises Commencement Date1 - March 31, 2016
	  	$	12,280.50	  
	 April 1, 2016-March 31, 2017
	  	$	12,648.92	  

 5. Operating Expense Share and Tax Share for Expansion Premises. Effective as of the Expansion Premises
Commencement Date and continuing for the Expansion Premises Term, Tenant shall make Tax Share and Operating Expense Share payments attributable to the Expansion Premises in accordance with the terms and conditions of Article 9 of the Lease, as
amended hereby; provided, however, that with respect to such payments for the Expansion Premises only, any reference in Article 9 to: 
  

	 	(a)	“Tenant’s Proportionate Building Share” shall be deemed to be a reference to 4.22%; 

  

	 	(b)	“Tenant’s Proportionate Common Share” shall be deemed to be a reference to 0.42%; and 

  

	 	(c)	“Premises” shall be deemed to be a reference to the Expansion Premises. 

 6.
Electricity Available to Expansion Premises. During the Expansion Premises Term, there shall be available to the Expansion Premises electrical facilities comparable to those supplied in other comparable office buildings in the vicinity of the
Building to provide power for normal lighting and machines of similar low electrical consumption, and one personal computer for each desk station. Tenant may not use any electrical appliances or equipment which, in the reasonable opinion of
Landlord, might overload the electrical risers, panels, switches, wiring or other electrical equipment or interfere with the use thereof by other tenants of the Building. Tenant may also not use any additional computers or extraordinary data
processing equipment, special lighting and any other item of electrical equipment which requires a voltage other than one hundred ten (110) volts single phase, as determined by Landlord in its sole and absolute discretion. If the installation
of such electrical equipment requires additional air conditioning capacity above that normally provided to tenants of the Building or above standard usage of existing capacity as determined by Landlord in its sole and absolute discretion, then the
additional air conditioning installation and/or operating costs attributable thereto shall be paid by Tenant. Tenant agrees not to use any apparatus or device in, upon or about the Expansion Premises which may in any way increase the amount of such
electricity usually furnished or supplied to the Expansion Premises, and Tenant further agrees not to connect any apparatus or device to the wires, conduits or pipes or other means by which such electricity is supplied, for the purpose of using
additional or unusual amounts of electricity, without the prior written consent of Landlord. At all times, Tenant’s use of electric current shall never exceed Tenant’s share of the capacity of the feeders to the Building or the risers or
wiring installation. Tenant shall not install or use or permit the installation or use in the Expansion Premises of 

  
 3 

 
any computer or electronic data processing or ancillary equipment or any other electrical apparatus designed to operate on electrical current in excess of 110 volts and 5 amps per machine,
without the prior written consent of Landlord, which may be exercised in Landlord’s sole and absolute discretion. If Tenant shall require electrical current in excess of that usually furnished or supplied for use of the Expansion Premises as
general office space, Tenant shall first procure the written consent of Landlord (which may be exercised in Landlord’s sole and absolute discretion) to the use thereof and Landlord or Tenant may (i) cause a meter to be installed in or for
the Expansion Premises, or (ii) if Tenant elects not to install said meter, Landlord may reasonably estimate such excess electrical current. The cost of any meters (including, without limitation, the cost of any installation) or surveys to
estimate such excess electrical current shall be paid by Tenant. Landlord’s approval of any space plan, floor plan, construction plans, specifications, or other drawings or materials regarding the construction of any alterations shall not be
deemed or construed as consent by Landlord under this Section 6 to Tenant’s use of such excess electrical current as provided above. 

7. Electricity Charges for Expansion Premises. During the Expansion Premises Term, (i) in the event that electricity consumption
for the Expansion Premises is separately metered, Tenant shall pay directly to the appropriate utility provider any and all costs of electricity utilized in or for the Expansion Premises and in support of any of Tenant’s equipment, wherever
located, or (ii) in the event that electricity consumption for the Expansion Premises is measured by a checkmeter, sub-meter or other measuring device, Tenant shall pay to Landlord, as additional rent, for Tenant’s electrical consumption
in the manner set forth in Section 8.1(b) of the Lease. Except for Section 8.1(a) of the Lease, the provisions of Section 8.1 of the Lease shall apply to the Expansion Premises. 

8. Hazardous Materials. Tenant shall not cause or permit any Hazardous Materials to be brought upon, kept or used in or about the
Expansion Premises by Tenant, its agents, employees, contractors or invitees, without the prior written consent of Landlord, except for Hazardous Materials which are typically used for cleaning purposes in connection with general office uses;
provided, that such materials are stored, used and disposed of in strict compliance with all applicable Environmental Laws. Within five (5) days of Landlord’s request, Tenant shall provide Landlord with a list of all Hazardous Materials
(including quantities used and such other information as Landlord may reasonably request) used by Tenant in the Expansion Premises. Notwithstanding the foregoing, with respect to any of Tenant’s Hazardous Materials which Tenant does not
properly handle, store or dispose of in compliance with all applicable Environmental Laws or any Hazardous Materials that are not typically used for cleaning purposes in connection with general office uses as determined by Landlord in its sole
discretion, Tenant shall upon written notice from Landlord, no longer have the right to bring such material into the Expansion Premises. 

9. Brokers. Landlord and Tenant each represents and warrants to the other party that it has not authorized, retained or employed, or
acted by implication to authorize, retain or employ, any real estate broker or salesman to act for it or on its behalf in connection with this Amendment so as to cause the other party to be responsible for the payment of a brokerage commission,
except for Cushman & Wakefield of Massachusetts and Cresa Boston (collectively, the “Brokers”). Any fees payable to the Brokers are the responsibility of Landlord pursuant to separate written agreement with the
Brokers. Landlord and Tenant shall each indemnify, defend and hold the other party harmless from and against any and all claims by any real estate broker or salesman (other than the Brokers) whom the indemnifying party authorized, retained or
employed, or acted by implication to authorize, retain or employ, to act for the indemnifying party in connection with this Amendment. 

10. Counterpart Execution. This Amendment may be executed in counterparts, each of which shall be deemed an original and all of which
when taken together shall constitute one fully 

  
  

	1	If the Expansion Premises Commencement Date shall not be the first day of a calendar month, Tenant shall be responsible for payment of the partial month of Yearly
Rent for the Expansion Premises, during the calendar month in which the Expansion Premises Commencement Date occurs, on a pro rata basis at the monthly rate of $12,280.50. 

  
 4 

 
executed original Amendment, binding upon the parties hereto, notwithstanding that all of the parties hereto may not be signatories to the same counterpart. Additionally, telecopied or e-mailed
signatures may be used in place of original signatures on this Amendment. Landlord and Tenant intend to be bound by the signatures on the telecopied or e-mailed document, are aware that the other party will rely on the telecopied or e-mailed
signatures, and hereby waive any defenses to the enforcement of the terms of this Amendment based on the form of signature. 
 11.
Miscellaneous. In all other respects, the Lease shall remain unmodified and shall continue in full force and effect, as amended hereby. The parties hereby ratify, confirm, and reaffirm all of the terms and conditions of the Lease, as amended
hereby. Tenant represents and warrants to Landlord that, as of the date hereof, (a) Tenant is not in default under any of the terms and provisions of the Lease, (b) there are no uncured defaults or unfulfilled obligations on the part of
Landlord under the Lease, and (c) no condition or circumstance exists which, with the giving of notice or the passage of time or both, would constitute a default by Landlord under the Lease. Tenant further acknowledges that Tenant has no
defenses, offsets, liens, claims or counterclaims against Landlord under the Lease or against the obligations of Tenant under the Lease (including, without limitation, any rental payments or other charges due or to become due under the Lease). 

12. Authorization to Execute. Tenant represents and warrants to Landlord that the person signing this Amendment on behalf of Tenant is
duly authorized to execute and deliver this Amendment on behalf of Tenant in accordance with a duly adopted resolution or other applicable authorization of Tenant, and that this Amendment is binding upon Tenant in accordance with its terms. Further,
if requested by Landlord, Tenant shall, within thirty (30) days after such request, deliver to Landlord a certified copy of a resolution or other applicable authorization of said organization authorizing or ratifying the execution of this
Amendment. 
 13. No Reservation. Preparation of this Amendment by Landlord or Landlord’s attorney and the submission of this
Amendment to Tenant for examination or signature is without prejudice and does not constitute a reservation, option or offer to lease the Premises. This Amendment shall not be binding or effective until this Amendment shall have been executed and
delivered by each of the parties hereto, and Landlord reserves the right to withdraw this Amendment upon written notice to Tenant from consideration or negotiation at any time prior to Landlord’s execution and delivery of this Amendment, which
withdrawal shall be without prejudice, recourse or liability. 
 [Signatures on Following Page] 

  
 5 

 IN WITNESS WHEREOF the parties hereto have executed this Second Amendment of Lease on the date
first written above in multiple copies, each to be considered an original hereof, as a sealed instrument. 
  

					
	LANDLORD:
	
	DWF IV ONE KENDALL, LLC, a Delaware limited liability company
			
		 	By:	 	Divco West Real Estate Services, Inc.,
		 		 	a Delaware corporation, its Agent

 
							
				
		 		 	By:	 	 /s/ Jeffrey Longnecker

		 		 	Name:	 	Jeffrey Longnecker
		 		 	Title:	 	Director

 
			
	
	TENANT:
	
	VISTERRA, INC., a Delaware corporation
		
	By:	 	 /s/ David Arkowitz

	Name:	 	David Arkowitz
	Title:	 	C.O.O. & C.F.O.

  
 6 

 EXHIBIT 2C - OUTLINE OF EXPANSION PREMISES 

This plan is intended only to show the general outline of the Expansion Premises as of the date of this Amendment. Any depiction of interior windows, walls,
cubicles, modules, furniture and equipment on this plan is for illustrative purposes only, but does not mean that such items exist. Landlord is not required to provide, install or construct any such items. It does not in any way supersede any of
Landlord’s rights set forth in the Lease or this Amendment with respect to arrangements and/or locations of public parts of the Building. It is not necessarily to scale; any measurements or distances shown should be taken as approximate. The
inclusion of elevators, stairways, electrical and mechanical closets, and other similar facilities for the benefit of occupants of the Building does not mean such items are part of the Expansion Premises.

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