Document:

EX-10.5

 Exhibit 10.5 

Amended and Restated Non-Employee Director Compensation Policy 

This Amended and Restated Non-Employee Director Compensation Policy applies to
non-employee directors, other than the chairperson or lead director, who are not affiliated with major investors. 

Subject to Board approval, the Company shall grant you, as a non-employee director of the Company, an option to
purchase 180,000 shares of the Company’s common stock at an exercise price per share equal to the fair market value per share of such common stock, as determined by the Board on the date of grant (the “Option”). The Option will
vest on the last date of each calendar quarter after the date of commencement of your service to the Company at the rate of 11,250 shares, provided that such vesting shall be contingent upon your continuing to provide services to the Company on each
such vesting date. Your Option shall be subject to the terms and conditions of the Company’s 2015 Equity Incentive Plan (the “Plan”) and form of Stock Option Agreement. No right to any stock is earned or accrued until such time
that Company common stock is delivered to you upon the exercise of the Option, nor does the Option confer any right to continue vesting or employment. 

Notwithstanding the foregoing, the shares underlying the Option shall vest in full (including with respect to any of such shares that have not yet vested)
upon a Sale Event. “Sale Event” shall mean any of the following: (i) the sale of all or substantially all of the assets of the Company on a consolidated basis to an unrelated person or entity, (ii) a
merger, reorganization or consolidation pursuant to which the holders of the Company’s outstanding voting power immediately prior to such transaction do not own a majority of the outstanding voting power of the surviving or resulting entity (or
its ultimate parent, if applicable), (iii) the acquisition of all or a majority of the outstanding voting stock of the Company in a single transaction or a series of related transactions by a person or entity or group of persons and/or
entities, or (iv) any other acquisition of the business of the Company, as determined by the Board; provided, however, that the Company’s first firm commitment underwritten public offering pursuant to an effective
registration statement under the Securities Act of 1933, as amended, covering the offer and sale by the Company of its equity securities, as a result of or following which the common stock shall be publicly held, any subsequent public offering or
any other capital raising event, public or private, or a merger effected solely to change the Company’s domicile shall not constitute a “Sale Event.” 

On or about the first anniversary of your initial grant, and each year thereafter, or as otherwise determined by the Board, the Company shall, subject to
Board approval, grant you, as a non-employee director of the Company, an option to purchase 25,000 shares of common stock of the Company (subject to adjustment for stock splits, stock dividends and other
similar recapitalizations after the date of this letter and prior to the date of grant), at an exercise price per share equal to the fair market value per share of such common stock, as determined by the Board on the date of such grant, vesting in
equal quarterly installments on the last day of each quarter after the vesting commencement date as determined by the Board, provided that such vesting shall be contingent upon your continuing to provide services to the Company on each such vesting
date and that the vesting of all shares underlying such option shall also accelerate in full upon the earlier of (i) a Sale Event (as defined above); (ii) the annual stockholder meeting (if Company is a public company), or (iii) the
one (1) year anniversary of the date of grant. Each option shall be subject to the terms and conditions of the Plan and form of stock option agreement. No right to any stock is earned or accrued until such time that Company common stock is
delivered to you upon the exercise of any option, nor does any option confer any right to continue vesting or employment. 

 Each year, the Company shall pay to you, as a non-employee director
of the Company a retainer of $25,000, to be paid in equal quarterly installments, provided that such payment shall be contingent upon your continuing to provide services to the Company on each payment date. As a
non-employee director of the Board, you would be entitled to reimbursement of reasonable, customary and documented travel expenses to Board meetings.EX-10.6

 Exhibit 10.6 

PLIANT THERAPEUTICS, INC. 

NON-EMPLOYEE DIRECTOR COMPENSATION POLICY 

The purpose of this Non-Employee Director Compensation Policy (the “Policy”) of Pliant Therapeutics,
Inc., a Delaware corporation (the “Company”), is to provide a total compensation package that enables the Company to attract and retain, on a long-term basis, high-caliber directors who are not employees or officers of the Company
or its subsidiaries (“Outside Directors”). This Policy will become effective as of the day prior to the effective time of the registration statement for the Company’s initial public offering of equity securities. In furtherance
of the purpose stated above, all Outside Directors shall be paid compensation for services provided to the Company as set forth below: 
  

	 	I.	 Cash Retainers 

(a) Annual Retainer for Board Membership: $35,000 for general availability and participation in meetings and conference calls of our
Board of Directors, to be paid quarterly in arrears, pro-rated based on the number of actual days served by the director during such calendar quarter. No additional compensation for attending individual Board
meetings. 
 (b) Additional Annual Retainers for Committee Membership: 

 

					
	 Audit Committee Chairperson:
	  	$	15,000	 
	 Audit Committee member:
	  	$	7,500	 
	 Compensation Committee Chairperson:
	  	$	10,000	 
	 Compensation Committee member:
	  	$	5,000	 
	 Nominating and Corporate Governance Committee Chairperson:
	  	$	8,000	 
	 Nominating and Corporate Governance Committee member:
	  	$	4,000	 
	 Research and Development Committee Chairperson:
	  	$	8,000	 
	 Research and Development Committee member:
	  	$	4,000	 

 (c) Additional Retainer for Non-Executive Chairperson or Lead
Director of the Board of Directors: $30,000 to acknowledge the additional responsibilities and time commitment of the Chairperson role, or in the absence of a Chairperson, of the Outside Director designated Lead Director. 

 

	 	II.	 Equity Retainers 

All grants of equity retainer awards to Outside Directors pursuant to this Policy will be automatic and nondiscretionary and will be made in accordance with
the following provisions: 

 (a) Value. For purposes of this Policy, “Value” means with respect
to (i) any award of stock options the grant date fair value of the option (i.e., Black-Scholes Value) determined in accordance with the reasonable assumptions and methodologies employed by the Company for calculating the fair value of options
under ASC 718; and (ii) any award of restricted stock and restricted stock units the product of (A) the closing market price on The Nasdaq Global Market (or such other market on which the Company’s Common Stock is then
principally listed) of one share of the Company’s Common Stock on the effective date of grant, or if no closing price is reported for such date, the closing price on the last date preceding such date for which a closing price is reported and
(B) the aggregate number of shares pursuant to such award. 
 (b) Sale Event Acceleration. In the event of a Sale Event
(as defined in the Company’s 2020 Stock Option and Incentive Plan (the “2020 Plan”)), the equity retainer awards granted to Outside Directors pursuant to this Policy shall become 100% vested and exercisable. 

(c) Initial Grant. Upon initial election or appointment to the Board of Directors, each new Outside Director will receive an initial, one-time grant of a non-statutory stock option to purchase 190,000 shares of the Company’s Common Stock (the “Initial Grant”) with an exercise price per
share equal to the closing price of a share of the Company’s Common Stock on the date of grant and a term of ten years, that vests substantially equal monthly installments over three years beginning on the grant date; provided, however, that
all vesting ceases if the director resigns from our Board of Directors or otherwise ceases to serve as a director, unless the Board of Directors determines that the circumstances warrant continuation of vesting. If any Initial Grant to an Outside
Director is to become effective as of the date of the Company’s initial public offering, it shall have an exercise price per share equal to the per share “price to the public” (or equivalent) set forth on the cover page for the final
prospectus relating to the Company’s initial public offering. This Initial Grant applies to Outside Directors who are first elected or appointed to, and who were not previously serving on, the Board of Directors effective as of or subsequent to
the Company’s initial public offering. 
 (d) Annual Grant. On the date of the Company’s Annual Meeting of Stockholders,
each Outside Director who will continue as a member of the Board of Directors following such Annual Meeting of Stockholders will receive a grant of a non-statutory stock option to purchase 95,000 shares of the
Company’s Common Stock (the “Annual Grant”) on the date of such Annual Meeting with an exercise price per share equal to the closing price of a share of the Company’s Common Stock on the date of grant and a term of ten
years, with 25% of the Annual Grant vesting on the first day of each calendar quarter following the grant date for three calendar quarters and the remaining 25% of the Annual Grant vesting on the earlier of (i) the one-year anniversary of the grant date or (ii) the next Annual Meeting of Stockholders; provided, however, that all vesting ceases if the director resigns from our Board of Directors or otherwise ceases
to serve as a director, unless the Board of Directors determines that the circumstances warrant continuation of vesting. 
  

	 	III.	 Expenses 

The Company will reimburse all reasonable out-of-pocket expenses incurred by
Outside Directors in attending meetings of the Board of Directors or any Committee thereof. 

	 	IV.	 Maximum Annual Compensation 

The aggregate amount of compensation, including both equity compensation and cash compensation, paid to any Outside Director in a calendar year period shall
not exceed (i) $1,000,000 in the first calendar year an individual becomes an Outside Director and (ii) $750,000 in any other year (or in each case, such other limits as may be set forth in Section 3(b) of the 2020 Plan or any similar provision
of a successor plan). For this purpose, the “amount” of equity compensation paid in a calendar year shall be determined based on the grant date fair value thereof, as determined in accordance with ASC 718 or its successor provision, but
excluding the impact of estimated forfeitures related to service-based vesting conditions. 
 Date Policy
Approved:            , 2020

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