Document:

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                                                                   Exhibit 10.94

Platinum Underwriters Holdings, Ltd
The Belvedere Building
69 Pitts Bay Road, 2nd Floor
Pembroke HM 08, Bermuda

31 December 2003

Dear Sirs

1.       INTRODUCTION: Platinum Underwriters Holdings, Ltd. (the "GUARANTOR")
has today entered into a Guarantee by way of deed poll (the "GUARANTEE") (a copy
of which is attached to this letter) pursuant to which the Guarantor has
guaranteed certain payment obligations of Platinum Re (UK) Limited (the
"COMPANY") under certain reinsurance contracts on, and subject to, the terms and
conditions of the Guarantee.

2.       GUARANTEE FEE: In consideration of the Guarantor entering into the
Guarantee, the Company shall pay to the Guarantor an annual fee (the "GUARANTEE
FEE"). The Company will pay the Guarantee Fee in the amount of $2,500,000 for
the period from January 1, 2004 through December 31, 2004. The Guarantee Fee for
each subsequent calendar year shall be an amount equal to 0.66% of the net
premium which the Company estimates it will write in such calendar year, as
determined by the Company. The Guarantee Fee shall be payable on or before the
31st day of March in the calendar year to which the Guarantee Fee relates. If
the actual amount of the net premiums written in any calendar year by the
Company, as reflected in the Company's annual audited accounts, differs from the
estimated amount of net premium used to calculate the Guarantee Fee for that
calendar year, the Guarantee Fee for that calendar year shall be adjusted
retroactively to reflect such actual amount of net premium written, and the
amount of such adjustment, together with interest thereon at the rate of 5% per
annum, shall be added to or subtracted from the amount of the Guarantee Fee
payable for the following calendar year.

3.       TERMINATION OF THE GUARANTEE: The obligation of the Company under this
letter agreement to pay the Guarantee Fee shall terminate on the last day of the
calendar year in which the Guarantee terminates or is revoked. The amount of any
adjustment to the Guarantee Fee for the calendar year in which the Guarantee
terminates or is revoked (together with interest) which would have been added to
the Guarantee Fee for the following calendar year pursuant to paragraph 2 of
this letter agreement shall be paid by the Company to the Guarantor within two
months of such adjustment being calculated. The amount of any adjustment to the
Guarantee Fee for the calendar year in which the Guarantee terminates or is
revoked (together with interest) which would have been subtracted from the
Guarantee Fee for the following

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calendar year pursuant to paragraph 2 of this letter agreement shall be paid by
the Guarantor to the Company within two months of such adjustment being
calculated.

4.       GUARANTEE PAYMENTS ARE DEMAND LOANS: All payments made by the Guarantor
under the Guarantee shall constitute loans from the Guarantor to the Company.
All such loans shall bear interest at 5% per annum and shall be repayable by the
Company within three (3) business days after the Guarantor has made written
demand, together with all accrued but unpaid interest.

5.       TAX WITHHOLDING: The Guarantee Fee and any interest paid on payments
made pursuant to paragraph 4 of this letter agreement shall be payable net of
withholding taxes that the Company determines are required to be withheld,
provided that if the Company withholds any such amounts, the Company shall pay
over the amount withheld to the appropriate tax authorities and provide the
Guarantor with a copy of the receipt for such payment. The Guarantor shall
indemnify the Company on an after-tax basis for any taxes, interest and
penalties assessed against the Company for failing to withhold unless the
Guarantor has notified the Company in writing to withhold and the Company fails
to do so, in which event the Guarantor shall indemnify the Company on an
after-tax basis for any taxes imposed upon the Company as a result of its
failure to withhold but not for any interest and penalties.

6.       SUCCESSORS AND ASSIGNS: This letter agreement may not be assigned by
either party hereto without the prior written consent of the other party. This
letter agreement shall be binding upon the Guarantor and the Company and their
respective successors and assigns.

7.       AMENDMENT: No term or provision of this letter agreement may be
amended, modified, altered, waived or supplemented except in writing signed by
Guarantor and the Company.

         1.       8.       Notices: ANY NOTICE, REQUEST, INSTRUCTION,
CORRESPONDENCE OR OTHER DOCUMENT TO BE GIVEN HEREUNDER TO THE GUARANTOR SHALL BE
GIVEN IN WRITING BY PERSONAL DELIVERY OR REGISTERED POST AS FOLLOWS (UNLESS A
SUBSEQUENT ADDRESS HAS BEEN PROVIDED):

                  Platinum Underwriters Holdings, Ltd.
                  The Belvedere Building
                  69 Pitts Bay Road, 2nd Floor
                  Pembroke HM 08, Bermuda

                  Attn: Michael E. Lombardozzi
                        General Counsel
                        Fax No.: (441) 298-0752

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Any notice, request, instruction, correspondence or other document to be given
hereunder to the Company shall be given in writing by personal delivery or
registered post as follows (unless a subsequent address has been provided):

                  Platinum Re (UK) Limited
                  52 Lime Street
                  London, EC3M 7NL, United Kingdom

                  Attn: Robert Porter
                        Managing Director
                        Fax No.: 44 207 623-6610

9.       GOVERNING LAW: This letter agreement shall in all respects be governed
by, and construed in accordance with, the laws of England and Wales.

10.      JURISDICTION: The parties hereby irrevocably submit to the jurisdiction
of the courts of England and Wales in any action or proceeding arising out of or
in relation to this letter agreement.

11.      CONTRACTS (RIGHTS OF THIRD PARTIES) ACT 1999: The parties to this
letter agreement do not intend that any term of this letter agreement should be
enforceable, by virtue of the Contracts (Rights of Third Parties) Act 1999, by
any person who is not a party to this letter agreement.

Please indicate your acceptance of the terms of this letter by signing and
returning the enclosed copy letter.

Yours faithfully,

/s/ Robert S. Porter
--------------------
for and on behalf of Platinum Re (UK) Limited

Acknowledged and agreed:

/s/ Gregory E.A. Morrison
-------------------------
for and on behalf of Platinum Underwriters Holdings, Ltd.
Date: December 31, 2003

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                      PLATINUM UNDERWRITERS HOLDINGS, LTD.

                                    Guarantee

         This Guarantee by way of deed poll (the "Guarantee"), dated as of
December 31, 2003, is made and entered into as a deed poll by Platinum
Underwriters Holdings, Ltd., a Bermuda company, (the "Guarantor") with its
officers located at The Belvedere Building, 69 Pitts Bay Road, 2nd Floor,
Pembroke HM 08, Bermuda.

         WHEREAS, Platinum Re (UK) Limited (the "Company"), a wholly-owned
indirect subsidiary of the Guarantor, is engaged in the reinsurance business and
intends to enter into certain Reinsurance Contracts (as defined below) with
Cedants (as defined below).

         WHEREAS, on and subject to the terms and conditions set forth herein,
the Guarantor desires to guarantee the Undisputed Obligations (as defined below)
under such Reinsurance Contracts.

         NOW THEREFORE, the Guarantor hereby covenants and agrees as follows:

         2.       Definitions. In this Guarantee:

"Cedant" means an insurance company, a reinsurance company or any other
reinsured who has entered into, and is named in, a Reinsurance Contract with the
Company;

"Reinsurance Contract" means a reinsurance contract entered into between the
Company and a Cedant on or after 31 December 2003; and

"Undisputed Obligations" means the Company's payment obligations to a Cedant
under a Reinsurance Contract, to the extent that such payment obligations are
not disputed or contested by the Company.

         3.       Guarantee. Subject to, and in accordance with, the terms and
conditions of this Guarantee, including without limitation Clauses 3 and 4
hereof, the Guarantor hereby absolutely and, subject to Clause 3 hereof,
unconditionally guarantees for the benefit of each Cedant the payment when due
of the Undisputed Obligations. This Guarantee shall constitute a guarantee of
payment of, and not of collection of, the Undisputed Obligations and subject to
Clause 7 hereof is a continuing guarantee of the full payment by the Company of
the Undisputed Obligations. Nothing in this Guarantee shall cause the liability
of the Guarantor under this Guarantee to exceed the amount of the Undisputed
Obligations.

         4.       Third Party Beneficiaries. The Guarantor intends that each
Cedant that is a party to a Reinsurance Contract will be a third party
beneficiary of this Guarantee. A Cedant shall only be entitled to take or obtain
the benefit of this Guarantee on condition that: (i) it first notifies the
Company in writing of the Company's failure to pay an Undisputed Obligation and
demands that payment be made by the Company of such Undisputed Obligation (the
"Demand Notice"); and (ii) the Company fails to pay such Undisputed Obligation
within thirty (30) days after the date of receipt of the

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Cedant's Demand Notice, and the Cedant makes a demand for payment of such
Undisputed Obligation under this Guarantee upon the Guarantor (a "Payment
Notice"). A Payment Notice shall be in writing and shall include a copy of the
Demand Notice, shall state that the Cedant is calling upon the Guarantor to pay
an Undisputed Obligation under this Guarantee and shall specify in reasonable
detail the nature of the relevant Undisputed Obligation, that the Company has
failed to pay the Undisputed Obligation and the date such payment was due. Upon
the failure by the Company to pay an Undisputed Obligation when due and payable,
the Guarantor shall pay or otherwise satisfy the Undisputed Obligation if it is
called upon to pay such Undisputed Obligation in a Cedant's Payment Notice
within thirty (30) business days of the Guarantor's receipt of the Payment
Notice; provided, however, that the Guarantor shall have no obligation to a
Cedant under this Guarantee unless the Cedant has complied with the provisions
of this Clause and the Guarantor has received a Payment Notice satisfying the
foregoing requirements and such other information as the Guarantor may
reasonably request from the Cedant.

         5.       Set-offs and Counterclaims. Without limiting the Guarantor's
own defences and rights hereunder, the Guarantor shall be entitled to all
rights, set-offs, counterclaims and other defences to which the Company or any
other subsidiary (as defined in section 736 of the Companies Act 1985) of the
Guarantor is or may be entitled, including without limitation, those arising
from or out of the Reinsurance Contracts. Notwithstanding the foregoing, the
liability of the Guarantor under this Guarantee shall not be reduced or
discharged by: (i) any change in the time, manner or place of payment of any of
the Undisputed Obligations; or (ii) any insolvency, winding-up, reorganization,
or other similar proceeding of the Company.

         6.       Subrogation. With respect to any Reinsurance Contract, the
Guarantor hereby unconditionally agrees that, until the payment and satisfaction
in full of all Undisputed Obligations under such Reinsurance Contract, it shall
not exercise any right or remedy arising by reason of any performance by it of
its obligations under this Guarantee, whether by subrogation or otherwise,
against the Company. Nothing in this clause or in this Guarantee shall prevent
the Guarantor from exercising any remedies or rights in order to safeguard or
otherwise preserve or maintain any such subrogation or other rights in whole or
in part.

         7.       Amendment of Guarantee. The Guarantor shall be permitted from
time to time and at any time to amend or vary the terms of this Guarantee,
provided that the liability of the Guarantor to a Cedant in respect of any
Undisputed Obligation incurred before, or arising out of an Undisputed
Obligation entered into before, the date of such variation or amendment, shall
not be in any way reduced or limited by such variation or amendment.

         8.       Termination.

         (a)      The Guarantor may terminate or revoke this Guarantee at any
time by publishing notice of such termination in the Financial Times newspaper,
or such other newspaper with daily circulation in London as the Guarantor may
select. Such notice

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will indicate the effective date of such termination or revocation (the
"Effective Date"), which may not be earlier than the fifth day following
publication of the notice. Subject to Clause 7(c) hereof, with effect from the
Effective Date the Guarantor shall have no further liability hereunder.

         (b)      This Guarantee shall terminate immediately as of the day (the
"Termination Date") the Guarantor ceases to control the Company. For the
purposes of this Clause 7, the term "control" means the ownership, either
directly or indirectly, of 50% or more of the ordinary shares in the capital of
the Company. Subject to Clause 7(c) hereof, with effect from the Termination
Date the Guarantor shall have no further liability hereunder.

         (c)      No termination or revocation of this Guarantee pursuant to
this Clause 7 shall affect the Guarantor's liability under this Guarantee with
respect to any Undisputed Obligations arising under any Reinsurance Contract
entered into prior to the Effective Date or, as the case may be, the Termination
Date, and the Guarantor's liability under this Guarantee in respect of such
Undisputed Obligations shall continue in full force and effect until all such
Undisputed Obligations have been satisfied.

         9.       Notice. Any Payment Notice or other notice, request,
instruction, correspondence or other document to be given hereunder to the
Guarantor shall be given in writing by personal delivery or registered post to
the following address (unless a subsequent address has been provided):

         Platinum Underwriters Holdings, Ltd.
         The Belvedere Building
         69 Pitts Bay Road, 2nd Floor
         Pembroke HM 08, Bermuda

         Attn: Michael E. Lombardozzi
               General Counsel
               Fax No.: (441) 298-0752

Any Demand Notice or other notice, request, instruction, correspondence or other
document to be given hereunder to the Company shall be given in writing by
personal delivery or registered post to the following address (unless a
subsequent address has been provided):

         Platinum Re (UK) Limited
         52 Lime Street
         London, EC3M 7NL, United Kingdom

         Attn: Robert Porter
         Managing Director
         Fax No.: 44 207 623-6610

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         10.      Miscellaneous.

         (a)      This Guarantee shall in all respects be governed by, and
construed in accordance with, the laws of England and Wales without giving
effect to the conflicts of law principles thereof.

         (b)      The Guarantor hereby irrevocably submits to the jurisdiction
of the courts of England and Wales in any legal action or proceeding arising out
of or in relation to this Guarantee. The Guarantor hereby appoints Platinum Re
(UK) Limited at 52 Lime Street, London EC3M 7NL as its agent for service of
process in connection with any such action or proceeding brought by a Cedant.

         (c)      The headings in this Guarantee are for purposes of reference
only, and shall not affect the meaning hereof.

     IN WITNESS WHEREOF, the Guarantor has executed and delivered this
Guarantee as a deed poll as of the date first above written.

Executed as a deed by                              )
PLATINUM UNDERWRITERS HOLDINGS, LTD.               )
acting by                                          ) /s/ Gregory E.A. Morrison
who, in accordance with the laws of the            ) ---------------------------
territory in which Platinum Underwriters           )    (Authorised signatory)
Holdings, Ltd. is incorporated, is acting under    )
the authority of Platinum Underwriters Holdings,   )
Ltd.                                               )

                                       7<PAGE>

                                                                 Exhibit 10.42.2

                                       January 28, 2004

BY FACSIMILE AND EXPRESS MAIL
CONFIDENTIAL
Peter A. Lankau
President
Endo Pharmaceuticals Inc.
100 Painters Drive
Chadds Ford, PA  19317

    Re: Amendment to Development, Commercialization and Supply License Agreement

Dear Peter:

Reference is made to the Development, Commercialization and Supply License
Agreement between Endo Pharmaceuticals Inc. ("Endo") and DURECT Corporation
("DURECT") effective November 8, 2002 ("Agreement"). Effective on the date
written above, Endo and DURECT hereby agree as follows:

         1.       Amendment to Section 4.6(a). Section 4.6(a) of the Agreement
                  shall be amended to change "June 30, 2004" to "January 1,
                  2005".

         2.       Restatement of Section 4.6(c). Section 4.6(c) of the Agreement
                  shall be deleted in its entirety, and in lieu thereof, the
                  following shall be inserted:

                  "(c) Notwithstanding anything to the contrary in Sections
                  4.6(a) and (b) and except as set forth in this Section 4.6(c),
                  Endo shall have no obligations under Sections 4.6(a) and (b)
                  to make any payments to DURECT for any Developments Costs
                  incurred up to and including the date on which the first
                  patient is dosed with the Product in the first clinical trial
                  of at least that number of patients necessary to satisfy the
                  FDA which occurs after the Effective Date (such date, the
                  "Trial Commencement Date" and such trial, the "First Trial").
                  Notwithstanding the foregoing: (i) in the event the Trial
                  Commencement Date has not occurred by December 31, 2003, then
                  during the period commencing on January 1, 2004 until the
                  earlier of the Trial Commencement Date or January 1, 2005,
                  Endo shall be responsible for 25% of the Development Costs
                  incurred in each such calendar month, up to an aggregate
                  payment by Endo to DURECT of $250,000 of Development Costs for
                  such period; and (ii) in the event the

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                  Trial Commencement Date has not occurred on or before January
                  1, 2005, then Endo shall be responsible for such portion of
                  the Development Costs incurred after January 1, 2005 in
                  accordance with Section 4.6(a). Furthermore, until the Trial
                  Commencement Date, DURECT hereby agrees to initiate any human
                  trial only if such trial and the initiation thereof is
                  consistent with a reasonable pharmaceutical company's overall
                  global strategic development plan for a product similarly
                  situated to the Product. Finally, in no event shall Endo be
                  liable for any costs associated with any human pharmacokinetic
                  (PK) study undertaken by DURECT prior to the earlier of the
                  Trial Commencement Date or January 1, 2005."

         3.       Restatement of Section 13.3(d). Section 13.3(d) of the
                  Agreement shall be deleted in its entirety, and in lieu
                  thereof, the following shall be inserted:

                  "(d) [INTENTIONALLY OMITTED.]"

         4.       Restatement of Section 13.3(e). Section 13.3(e) of the
                  Agreement shall be deleted in its entirety, and in lieu
                  thereof, the following shall be inserted:

                  "(e) In the event that the Trial Commencement Date shall not
                  have occurred on or before January 1, 2005, Endo shall have
                  the right to terminate this Agreement effective upon 10 days'
                  written notice with no further rights or obligations hereunder
                  (other than those rights or obligations which are expressly
                  indicated herein to survive termination or expiration of this
                  Agreement); provided that such written notice is delivered to
                  DURECT no later than January 31, 2005."

         5.       New Section 4.10. A new Section 4.10 shall be added to the
                  Agreement as follows:

                  "4.10 Retention of Key Personnel. DURECT shall use its
                  reasonable efforts to retain key personnel involved with the
                  development of the Product. Such key personnel shall be those
                  individuals identified as such by the JEC. In the event that a
                  member of the key personnel leaves the employ of DURECT
                  (either on his/her own volition or otherwise), DURECT shall,
                  within three (3) business days of such departure, inform

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                  Endo of (1) such fact and (2) DURECT's plan as to how it
                  intends to address the departure of such key personnel to
                  ensure the smooth continuance of the Development Program."

Except as set forth above, all other terms of the Agreement shall remain the
same. Please sign below to indicate Endo's agreement to the foregoing.

                                                     Very truly yours,

                                                     /s/ JAMES E. BROWN

                                                     James E. Brown
                                                     President and CEO

AGREED TO BY ENDO:

By: /s/ PETER A. LANKAU
    ----------------------
         Peter A. Lankau
         President

Date: January 28, 2004

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