Document:

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                                                                    Exhibit 10.5

                            PRO-PHARMACEUTICALS, INC.

                              CONSULTING AGREEMENT
                                (David H. Smith)

         CONSULTING AGREEMENT entered into as of January 16, 2003 (the
"Effective Date"), by and between Pro-Pharmaceuticals, Inc., a Nevada
corporation having an address of 189 Wells Avenue, Newton, Massachusetts 02459
(the "Company") and David H. Smith, an individual having an address of 34
Shorehaven Road, Norwalk, Connecticut 06855 ("Consultant").

         WHEREAS, the Company has requested that the Consultant provide certain
consulting services in connection with the business development and related
financial services for the Company, and other professional tasks for the Company
as it may request (the "Services"); and

         WHEREAS, the Consultant is willing to provide Services to the Company
in connection with the terms and conditions herein set forth;

         NOW, THEREFORE, for valuable consideration, the receipt and sufficiency
of which are hereby acknowledged, the parties hereto agree as follows:

         1. Provision of Services. The Consultant agrees to provide Services as
stated above and as directed by the Company.

         2. Compensation. In consideration of the Services, the Company shall
grant to the Consultant, pursuant to a non-qualified stock option agreement,
substantially in the form attached hereto as Exhibit A, an option to purchase
100,000 shares of the Company's common stock, exercisable at $3.50 per share,
with such option to vest as follows: 33,334 as of the option grant date, 33,333
on the first anniversary of the grant date, and 33,333 on the second anniversary
of the grant date, provided that the Consultant continues to be a director of
the Company on each applicable vesting date. If the Consultant ceases to be a
director before the option is fully vested, the option will vest, for the year
in which such termination occurs, pro rata as of the termination date based on
the amount that would have otherwise vested for the full year.

         3. Expenses. The Company shall reimburse the Consultant for
out-of-pocket expenses reasonably incurred by the Consultant in the course of
performing the Services, provided Consultant delivers vouchers or other
documentation evidencing such expenses to the satisfaction of the Company.

         4. Termination.

         (a) Without Cause. This Consulting Agreement has no defined term and
may be terminated by either party for any reason and without cause upon thirty
(30) days' prior written notice.

         (b) Termination for Cause. The Company shall have the right, upon
written notice thereof to the Consultant, to terminate immediately the
Consultant's engagement pursuant to this Agreement (such termination, for
"cause") if the Consultant (i) is grossly negligent in the performance of
Services and other duties hereunder, (ii) is convicted of a felony or other
violation which in the reasonable judgment of the Company' senior

                                      -1-

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management could materially impair the Company from substantially meeting its
business objectives, (iii) has in the reasonable judgment of such management
breached Section 5, 6 or 7 hereof, or (iv) is found to have committed any act of
fraud, misappropriation of funds or embezzlement with respect to the Company.

         (c) Effect of Termination. No termination of this Consulting Agreement
shall affect the obligations, promises or covenants contained herein which are
expressly made to extend beyond the term of this Consulting Agreement,
including, without limitation, as set forth under Section 5, 6 or 7 hereof. The
effective date of termination of this Consulting Agreement is referred to as the
"Termination Date".

         5. Property; Confidentiality.

         (a) Definitions. For the purposes of this Consulting Agreement the
following terms shall have the meanings set forth below:

         "Confidential Information" shall mean all information related to the
business, operations, products or services of the Company, and all reports,
presentations, drawings, know-how, data, inventions, discoveries, improvements,
ideas, plans, analysis, memoranda and other information or materials provided to
Consultant by or on behalf of the Company and/or its subsidiaries and other
affiliates, collectively and individually, or developed by Consultant in
connection with Consultant's engagement by the Company (including, without
limitation, the Work) or arising out of the Work, or preparation for it or other
related activities.

         "Work" shall mean all designs, plans, presentations, reports, know-how,
data, inventions, discoveries, improvements, ideas, trademarks, copyrights, and
other works of authorship, and all other materials, information, work or other
intangible or intellectual property, collected, prepared, developed or edited by
Consultant in the performance of or in connection with the Services.

For the purpose of this Section 5, the term "Company" shall include the Company
and its respective subsidiaries and other affiliates, collectively and
individually.

         (b) Intellectual Property Rights. The parties acknowledge and agree
that any Work being created at the instance of the Company will be deemed work
made for hire under the United States copyright laws. The Company shall have the
right to use all or any portion of the Work as it sees fit. The Company may
alter the Work, add to it, or combine it with any other work or works, in its
sole discretion. All rights in and to the Work and all material submitted by
Consultant to the Company as part of the Work or part of the process of creating
the Work, will be the property of the Company whether or not ultimately used by
the Company. No rights in or to the Work are reserved to Consultant.

         (c) Assignment of Property. This Consulting Agreement shall operate as
a perpetual, unlimited, and irrevocable assignment by Consultant to the Company
of the copyright and any and all other proprietary or other intellectual
property rights or interests, in or to any Work, held by or on behalf of
Consultant (including, without limitation, any such interest arising as a result
of a determination that the Work does not constitute a work made for hire under
the United States copyright laws). In the event of any dispute arising out of or
concerning this Consulting Agreement, no acts of the Company undertaken for the
purpose of prosecuting, registering or preserving any patent or copyright in the
Work shall be considered in determining the character of the Work as a work made
for hire. Consultant shall execute such documents and do such further acts as
Company may request

                                      -2-

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reasonably (and subject to Company's reimbursement of Consultant's out of pocket
expense of doing so) to perfect Consultant's rights in the Work and said
intellectual property rights and aid in enforcement and exploitation of such
rights and the assignment of the Consultant's rights to the Company.

         (d) Confidentiality. Consultant agrees to (i) refrain from using the
Confidential Information for any purpose that would be adverse to the interests
of the Company, and (ii) hold the Confidential Information strictly confidential
and not disclose it to any person or entity other than the Company's employees
or representatives. The foregoing obligations shall not apply to any information
that (i) is publicly known at the time of its disclosure, (ii) is lawfully
received by Consultant from a third party not under an obligation of
confidentiality to the Company, (iii) is published or otherwise made known to
the public by the Company, or (iv) was generated independently by Consultant
without reference to or the use of Confidential Information. Consultant's
obligation under this subsection shall survive any termination of this
Consulting Agreement.

          (e) Return of Confidential Information. Consultant shall deliver
promptly to the Company after the Termination Date, and at any other time as the
Company may request, all Confidential Information, which shall at all times be
and remain the property of the Company.

         6. Non-Competition. The Consultant agrees that during the period in
which he provides Services and for one (1) year after the Termination Date,
without prior written permission from the Company, the Consultant will not use
the Confidential Information, Work or other results of the Services in any
manner which could directly or indirectly compete with the business of the
Company. For purposes of the foregoing, the Consultant shall not, directly or
indirectly, be engaged by or invest in any entity involved in the application of
carbohydrate-based chemistry as a technique to reduce toxicity of, or increase
efficacy of, pharmaceuticals (a "Competitive Entity"), whether by way of
becoming an agent, employee, director, officer, partner, stockholder, consultant
or otherwise; provided, however, that the foregoing shall not prohibit the
Consultant from merely investing in any entity competitive with the Company
whose securities are listed on a national securities exchange, or traded in any
established over-the-counter securities market.

         7. Non-Solicitation. During the period in which Services are rendered
and for a period of two (2) years immediately after the Termination Date, the
Consultant shall not (i) either directly or indirectly solicit or take away, or
attempt to solicit or take away employees of the Company, either for the
Consultant's own business or for any other person or entity, or (ii) either
directly or indirectly recruit, solicit or otherwise induce or influence any
proprietor, partner, stockholder, lender, director, officer, employee, sales
agent, joint venturer, investor, lessor, supplier, customer, agent,
representative or any other person which has a business relationship with the
Company to discontinue, reduce or modify such employment, agency or business
relationship with the Company.

         8. Injunctive Relief. The Consultant acknowledges that a violation of
Sections 5, 6 or 7 of this Consulting Agreement would cause irreparable harm to
the Company for which no adequate remedy at law exists and the Consultant
therefore acknowledges and agrees that, in addition to any other remedies
available, the Company shall be entitled to injunctive relief to enforce the
terms of this Consulting Agreement, without waiving available damages, remedies
or other relief.

         9. Waiver of Liability. The Consultant acknowledges that the Company
shall bear no liability for (a) bodily and/or personal injury or death or
property damage caused to

                                      -3-

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the Consultant, its employees or agents, or others by the Consultant in the
performance of the Services, (b) medical expenses or injuries sustained by the
Consultant, its employees or agents in the performance of the Services, or (c)
any professional liability of the Consultant.

         10. Independent Contractor. The Consultant is an independent
contractor, and is not, and shall not be considered (by virtue of this
Consulting Agreement or otherwise) an employee, agent, partner or joint venturer
of the Company, whether for tax purposes or any other purpose. The Consultant is
not authorized to act on behalf of the Company, and shall not have the right to
bind the Company to any agreement with a third party or to incur any obligation
or liability on behalf of the Company.

         11. Dispute Resolution.

         The parties shall follow the following dispute resolution processes in
connection with any and all disputes, controversies or claims arising out of
this Consulting Agreement:

         (i) The Company and the Consultant (collectively, the "Parties" and
individually, a "Party") shall attempt to settle any disputes through good faith
negotiations between and among them.

         (ii) If the Parties should fail to resolve the dispute within 30 days
after the date of the initial demand for negotiation, then the Parties shall
refer the matter to mediation conducted by JAMS/Endispute, Boston, Massachusetts
office, or such other mediation service as the Parties may mutually agree upon,
and shall attempt in good faith to settle the dispute before such mediation
agency. Each Party shall bear its own expenses in connection with the mediation,
and shall equally share the filing and other administrative fees of the
mediation service. The Parties shall be represented in the mediation by
representatives having final settlement authority over the matter in dispute.

         (iii) Any dispute not finally resolved within 90 days after the initial
demand for negotiation shall be referred to the American Arbitration
Association, Boston, Massachusetts Office ("AAA") for binding arbitration.
Selection of one neutral arbitrator by the Parties shall be from the panel list
provided by the AAA and in accordance with the appointment rules of the AAA.
Each Party shall bear its own expenses in connection with any arbitration and
the Parties shall equally share the filing and other administrative fees of the
AAA and the expenses of the arbitrator; provided, however, that the prevailing
Party shall be entitled to receive from the non-prevailing Party reimbursement
of all expenses, including without limitation reasonable attorneys' fees,
incurred in connection with any such arbitration proceeding.

         12. Compliance by Consultant Personnel. Consultant represents and
warrants that (i) it has informed and will inform such of its employees, agents
or other personnel, if any, who perform Services as to the requirements of this
Consulting Agreement and (ii) such employees, agents or other personnel shall
have entered into such written agreements with Consultant in order to assure
that the Company shall have the benefits of the rights and obligations under
Sections 5, 6 and 7 hereof.

         13. Miscellaneous.

         (a) Entire Agreement; Amendment. This Consulting Agreement constitutes
the entire understanding of the parties with respect to its subject matter, may
be modified only in a writing signed by both parties, and shall supersede any
and all other agreements between them regarding such subject matter.

                                      -4-

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         (b) No Assignment. This Consulting Agreement shall not be transferred
or assigned by either party without the prior written consent of the other
party.

          (c) Waiver. Any waiver of a violation of this Consulting Agreement
shall only constitute a waiver of that particular violation and shall not
constitute a waiver of any different or continuing default. The exercise of any
right or remedy provided in this Consulting Agreement shall be without prejudice
to the right to exercise any other right or remedy provided by law or equity.

         (d) Modification of Invalid Provisions. If any provision of this
Consulting Agreement is found to be invalid, illegal or unenforceable, a
modified provision shall be substituted which carries out as nearly as possible
the original intent of the parties and the remaining provisions shall in not be
affected by such modification.

         (e) Notices. Any notice or other communication required or permitted to
be made under this Consulting Agreement shall be sufficiently made or given on
(i) date of personal delivery if delivered in person, (ii) the next day after
sending if sent by fax or next-day courier service, or (iii) the third day after
mailing if sent certified or registered mail or air mail, postage prepaid, and
addressed to the other party at the address set forth on the first page of this
Consulting Agreement or to any other address designated by the other party in
writing.

         (f) Governing Law. This Consulting Agreement shall be governed by and
construed in accordance with the laws of the Commonwealth of Massachusetts,
without giving effect to its principles on conflict of laws.

                  [Remainder of Page Intentionally Left Blank]

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         IN WITNESS WHEREOF, the parties hereto have executed this Consulting
Agreement as of the date and year first above written.

                                       PRO-PHARMACEUTICALS, INC.

                                       By: /s/ David Platt
                                           --------------------------
                                           David Platt, Ph.D.
                                           President

                                       /s/ David H. Smith
                                       ------------------------------
                                       David H. Smith

                                      -6-

<PAGE>

                                    Exhibit A

                            PRO-PHARMACEUTICALS, INC.

                      NON-QUALIFIED STOCK OPTION AGREEMENT

         Non-Qualified Stock Option Agreement dated as of January 16, 2003, by
and between Pro-Pharmaceuticals, Inc., a Nevada corporation, (the "Company"),
and David H. Smith (the "Optionee").

The parties agree as follows:

1. Grant. In consideration of the services provided to the Company by the
Optionee pursuant to the Consulting Agreement, dated as of January __, 2003, by
and between the Company and the Optionee (the "Consulting Agreement"), the
Company hereby grants, effective as of the date hereof (the "Effective Date"),
to the Optionee, an option (the "Option") exercisable for $3.50 per share to
purchase one hundred thousand (100,000) shares of common stock, par value $.001
per share, of the Company (the "Common Stock"), subject to the following terms
and conditions.

2. Vesting and Exercise Rights. The Option shall vest and become exercisable
only as follows, provided, in each case, that the Optionee continues to be a
director of the Company on each applicable vesting date:

                                             Number of Shares
         Date                                for which Option Exercisable
         ----                                ----------------------------
         Effective Date                      33,334

         First year anniversary              33,333
         of the Effective Date

         Second year anniversary             33,333
         of the Effective Date

If the Consultant ceases to be a director before the option is fully vested, the
option will vest, for the year in which such termination occurs, pro rata as of
the termination date based on the amount that would have otherwise vested for
the full year.

3. Relationship to Plan. The Option is not granted pursuant to the Company's
2001 Stock Incentive Plan (the "Plan").

4. Termination of Option. Exercise rights with respect to the Option shall
terminate on the tenth year anniversary of its date of grant unless the
Optionee's death occurs prior to such date in which event the termination date
shall be the first anniversary of the date of death.

5. "Lock-Up" Agreement. The Optionee agrees that upon the Company's request at
any time, whether before or after the exercise of the Option, the Optionee shall
enter into an agreement pursuant to which, if the Company deems it necessary or
desirable to make any public offering of shares of Common Stock, then without
the prior written consent of the Company or the managing underwriter, if any, of
any such offering, the Optionee shall not sell, make any short sale of, loan,
grant any option for the purchase of, pledge, or otherwise

                                      -1-

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encumber or otherwise dispose of any shares of Common Stock issued or issuable
pursuant to the Option, during such period (not to exceed 210 days) commencing
on the effective date of the registration statement relating to such offering as
the Company may request.

6. Methods of Exercise. In the event that the Optionee's service as a consultant
under the Consulting Agreement has not been terminated and except as contained
in this ss.6 or as may otherwise be agreed by the Optionee and the Company, the
Option shall be exercisable only by a written notice in form and substance
acceptable to the Company (the "Election Notice"), specifying the number of
shares to be purchased and accompanied by payment in cash of the aggregate
purchase price for the shares for which the Option is being exercised; provided,
that the Optionee shall be entitled to pay the Exercise Price for the shares of
Common Stock for which the Option is being exercised by surrendering a number of
such shares having a Fair Market Value equal to the Exercise Price required to
be paid. Thereupon, the Company shall issue to the Optionee such number of fully
paid and nonassessable shares of Common Stock as is computed using the following
formula:

         X = Y (A-B)
             -------
                A

Where X = the number of shares of Common Stock to be issued to the Optionee
pursuant to this ss.6;

Y = the number of shares of Common Stock currently being exercised under this
Option;

A = the Fair Market Value for the Common Stock as of the date of the exercise;
and

B = the Exercise Price in effect under this Option at the time the exercise is
made pursuant to this ss.6.

7. Characterization of Option for Tax Purposes. The Option is intended not to
qualify as an "incentive stock option" under the Internal Revenue Code of 1986,
as amended, and shall be subject to different tax treatment than that accorded
incentive stock options.

8. Withholding. At the request of the Company, the Optionee agrees to remit to
the Company an amount sufficient to satisfy any federal, state, local or other
withholding tax requirements (whether so required to secure for the Company an
otherwise available tax deduction or otherwise) if and to the extent required by
law prior to the delivery of any certificate or certificates representing shares
of Common Stock to be issued upon exercise of the Option.

                                      -2-

<PAGE>

9. Compliance with Laws. The obligations of the Company to sell and deliver
Shares upon exercise of the Option are subject to all applicable laws, rules,
and regulations, including all applicable federal and state securities laws, and
the obtaining of all such approvals by government agencies as may be deemed
necessary or appropriate by the Board of Directors of the Company (the "Board")
or the relevant committee of the Board. If so required by the Board or such
committee, no shares shall be delivered upon the exercise of the Option until
the Optionee has given the Company a satisfactory written statement that he is
purchasing such shares for investment, and not with a view to the sale or
distribution of any such shares, and with respect to such other matters as the
Board may deem advisable in order to assure compliance with applicable
securities laws. All shares issued upon exercise of the Option shall bear
appropriate restrictive legends.

10. General. The Optionee may not transfer, assign, or encumber any of his or
her rights under this Agreement without the prior written consent of the
Company, and any attempt to do so shall be void. This Agreement shall be
governed by and interpreted and construed in accordance with the internal laws
of the Commonwealth of Massachusetts (without reference to principles of
conflicts or choice of law). The captions of the sections of this Agreement are
for reference only and shall not affect the interpretation or construction of
this Agreement. This Agreement shall bind and inure to the benefit of the
parties and their respective successors, permitted assigns, heirs, devisees, and
legal representatives.

         IN WITNESS WHEREOF, the Company and the Optionee have executed and
delivered this Agreement, which may be in counterpart originals, intending it to
be effective as an agreement under seal as of the Effective Date.

                                       PRO-PHARMACEUTICALS, INC.

                                       By:
                                           -----------------------------
                                           Name:
                                           Title:

                                       Optionee:

                                       ---------------------------------
                                       David H. Smith

                                      -3-<PAGE>

                                                                   Exhibit 10.53

[LOGO]  Miller-Valentine Group 4000
        Miller-Valentine Court Dayton,
        Ohio 45439-1487
        P.O. Box 744
        Dayton, Ohio 45401-0744

        937-293-0900 937-299-1564
        FAX www.mvg.com

        July 31, 2002

                                        Via U.S. Mail
                                        -------------

        Steve Markiewicz
        PC Connection
        730 Milford Road Route 101A
        Merrimack, NH 03054-4631

        Re: Executed Lease Amendment #4 for
            Approximately 102,400 Square Feet of Space for
            2780-2880 Old State Route 73, Wilmington, OH 45177

         Dear Steve:

         Enclosed is a fully executed copy of the above referenced Lease
         Amendment and a copy of the State of Ohio Agency Disclosure Form for
         your files.

         Should you need any additional information, please contact me at
         937-293-0900.

         Sincerely,

         MILLER-VALENTINE REALTY, INC.

         /s/ Chuck McCosh

         Chuck McCosh
         Senior Vice President of Sales

         CM/ts

         Enclosure

         cc: Robert Pratt

         For more information about Miller-Valentine services and products,
         please visit our web site at www.mvg.com.

                      NAIOP National Developer of the Year

<PAGE>

                        Disclosure of-Agency Relationship

                          (THIS FORM IS NOT A CONTRACT)

This real estate agent who is providing you with this form is required to do so
by Ohio law. It does not, by itself, obligate you to work with this agent or
his/her brokerage; nor will you be bound to pay any compensation to the agent or
the agent's brokerage by merely signing this form.

Instead, the purpose of this form is to make sure you have the necessary
information you need to know about the role of this agent if you choose to work
together. By signing, you acknowledge that you have been provided this
information and agree to it. If you do not, you can consult with an attorney for
further advice.

As a potential seller/landlord or buyer/tenant of real estate I understand and
agree that

    Chuck McCosh      and     Miller-Valentine Realty, Inc.    will:
    ------------              -----------------------------
        (Agent)                          (Brokerage)

    [X] Represent the seller/landlord
    [_] Represent the buyer/tenant

I also understand and agree that the following may also possibly occur in a real
estate transaction in which I may be involved with this agent:

    [X] The same agent who represents me could potentially represent the other
        party in a transaction involving me. The agent and brokerage would then
        both be dual agents.

    [X] A different agent in the same brokerage could potentially represent the
        other party in a transaction involving me. Each agent would represent
        the interests of their separate client. The brokerage would be dual
        agent. A management level licensee is also a dual agent if representing
        a client in an in-com y transaction.

I have reviewed the information on the reverse side of this form and I have been
given a completed copy of this Disclosure of Agency Relationship.

                                    FIVE WAREHOUSE INVESTMENTS, V LTD.
Merrimack Service Corp. dba
PC Connection, Inc.                 By Miller-Valentine Realty, Inc.,

/s/ Robert A. Pratt  7/30/02           /s/ Robert A. Gallinis            7/31/02
--------------------------------       -------------------------------   -------
(Buyer or Tenant)     (Date)            (Seller or PRESIDENT)             (Date)

                                                                         7/31/02
(Buyer or Tenant)    (Date)         By _______________________________   -------
                                       (Seller or landlord)               (Date)
                                       Robert A. Gallinis. President

     To be completed only in an in-company transaction involving two agents
                                ("Split" Agency)

Both buyer/tenant and seller/landlord acknowledge and agree that in a
contemplated transaction involving property located at__________________________
____________________________ the buyer/tenant is represented by
                and the seller/landlord is represented by

By initialing below both parties acknowledge and agree that they are aware that
both agents are affiliated with the same brokerage; that each agent will
represent the separate interests of their separate client, (unless a management
level licensee is one of the agents involved in the transaction); that it was
previously disclosed that this could occur; and that they consent to the
brokerage acting as a dual agent.

Buyer/Tenant's   Initials:          Seller/Landlord's      Initials:
Date:                               Date:

          Any questions regarding the role or responsibilities of the
[SEAL]    brokerage or its agents can be directed to an attorney or to:   [SEAL]
             Ohio Division of Real Estate and Professional Licensing
                          77 S. High Street, 20th Floor
                            Columbus, OH 43266-0547
                                  (614)466-4100

                                  Page 2 of 2

<PAGE>

                            AMENDMENT NO. 4 TO LEASE

           THIS AGREEMENT made this 31 day of 2002 July, 2002, by and between
EWE WAREHOUSE INVESTMENTS V, LTD., as Lessor and MERRIMACK SERVICES CORPORATION
dba PC CONNECTION SERVICES, as Lessee located at 2780-2880 Old State Route 73,
Wilmington, Ohio 45177.

                                  WITNESSETH:

           WHEREAS, Lessor and Lessee entered into a Lease dated September 27,
1990 as amended June 28, 1996, July 31, 1998, and June 26, 2000, and

           WHEREAS, the Lessor and Lessee desire to amend the Lease of
approximately 102,400 square feet to extend the term, revise the rent and delete
the Option to Renew.

           NOW THEREFORE, the Lease is amended as follows.

           1. Article 1.  TERM. shall be revised as follows.

           Effective January 1, 2003, the term of this Lease shall be extended
for an additional two (2) years, two (2) months for a total term of fourteen
(14) years, two (2) months, commencing January 1, 1991 and ending February 28,
2006, both dates inclusive.

           2. Lessee warrants that Lessee has accepted and is now in possession
of the Premises and that the Lease is valid and presently in full force and
effect. Lessee accepts the Premises in its present "as is" condition.

           3. Article 4. RENT. shall be revised as follows.

           For the two (2) month period commencing January 1, 2003 and ending
February 28, 2003, the Lessee shall occupy the Leased Premises "rent free".

           For the ten (10) month period commencing March 1, 2003 and ending.
December 31, 2003 the Lessee shall pay to the Lessor as Rent for the Leased
Premises the sum of FOUR HUNDRED FORTY-EIGHT THOUSAND AND 00/100 DOLLARS
($448,000.00) which shall be paid in equal monthly installments of FORTY-FOUR
THOUSAND EIGHT HUNDRED AND 00/100 DOLLARS ($44,800.00), due and payable on the
first day of each month, in advance, without demand.

           Checks should be made payable to Easton & Associates Management
Account c/o The Easton Group, 10165 N. W. 19th St., Miami, FL 33172

           The Basic Annual Rent of $537,600.00 shall be adjusted annually based
on any increases in the. Consumer Price Index beginning January 1, 2004 and at
the end of each year thereafter, whether during the term of this Lease or any
renewal or extension thereof. Increases in the Annual Rent shall be made in
accordance with the following procedure:

           a. The index to be used for this adjustment shall be the Consumer
Price Index (U.S. City Average, All Urban Consumers, All Items, 1982-1984
equaling a base of 100, from the U.S. Department of Labor, Bureau of Labor
Statistics, Washington, D.C.).

<PAGE>

           b. The Consumer Price Index of 2002 for the month of September shall
be the "Base Period Consumer Price Index". The Consumer Price Index for the
month of September in each adjustment year shall be the "Adjustment Period
Consumer Price Index".

           c. The Base Period Consumer Price Index shall be subtracted from the
Adjustment Period Consumer Price Index; the difference shall be divided by the
Base Period Consumer Price Index. This quotient shall then be multiplied by the
Basic Annual Rent, and the result shall then be added to the Basic Annual Rent.
The resulting sum shall be the adjusted Annual Rent for such immediately
succeeding leasehold period which shall be paid in equal monthly installments.

           All calculations of said procedure shall be provided to the Lessee in
their entirety directly from EWE Warehouse Investments V, Ltd., the Lessor.

           d. If the said Consumer Price Index is, at any time during the term
of this Lease, discontinued by the Government, then the most nearly comparable
index shall be substituted for the purpose of the aforesaid calculations.

           4. Amendment No. 3, Item 6. OPTION TO RENEW. shall be amended as
follows.

           Lessee is hereby granted an option to renew this Lease for an
additional term of two (2) years on the same terms and conditions contained
herein except for the rental and the length of the term, upon the conditions
that:

           a. written notice of the exercise of such option shall be given by
Lessee to Lessor not less than one hundred eighty (180) days prior to the end of
the term of this Lease (by August 31, 2005); and

           b. at the time of the giving of such notice and at the expiration of
the term of this Lease, there are no defaults in the covenants, agreements,
terms and conditions on the part of Lessee to be kept and performed, and all
rents are and have been fully paid. Provided also, that the rent to be paid
during each year of the said renewal period shall be as determined in accordance
with the following procedure:

           (1) The index to be used for this adjustment shall be the Consumer
Price Index (U.S. City Average, All Urban Consumers, All Items, 1982-1984
equaling a base of 100, from the U.S. Department of Labor, Bureau of Labor
Statistics, Washington, D.C.).

           (2) The Consumer Price Index of 2002 for the month of September shall
be the "Base Period Consumer Price Index".

           (3) The Consumer Price Index for the month of September each
succeeding year shall be determined from the published figures and shall be the
"Adjustment Period Consumer Price Index".

           (4) The Base Period Consumer Price Index shall be subtracted from the
Adjustment Period Consumer Price Index; the difference shall be divided by the
Base Period Consumer Price Index. This quotient shall then be multiplied by
$537,600.00 and the result shall then be added to $537,600.00. This arithmetical
sum shall then be the adjusted Basic Annual Rent for such immediately succeeding
leasehold year which shall be paid in equal monthly installments.

           (5) If the said Consumer Price Index is, at any time during the term
of this Lease, discontinued by the Government, then the most nearly comparable
index shall be substituted for the purpose of the aforesaid calculations.

<PAGE>

          All calculations of said procedure shall be provided to the Lessee in
    their entirety directly from EWE Warehouse Investments V, Ltd., the Lessor.

          5. ARTICLE 21. NOTICE. shall be revised as follows.

          All notices under this Lease may be personally delivered sent by
    courier service, with receipt; or mailed to the address shown by certified
    mail, return receipt requested. The effective date of any mailed notice
    shall be one (1) day after delivery of the same to the United States Postal
    Service.

                                Lessor: EWE Warehouse Investments V, Ltd.
                                Mail:   Easton & Associates
                                        Management Account
                                        c/o The Easton Group 10165 N.
                                        W. 19_ St. Miami, FL 33172

                                Lessee: MERRIMACK SERVICES CORPORATION
                                        dba PC CONNECTION SERVICES
                                Mail:   Attn: Legal Counsel
                                        730 Milford Road
                                        Merrimack, NH 03054-4631

          Either party may from time to time designate in writing other
    addresses.

          6. Except as expressly amended herein, all other terms and conditions
    of the Lease remain in full force and effect.

          IN WITNESS WHEREOF, the Lessor' and Lessee have affixed their
    signatures to duplicates of this Amendment, this 30 day of July, 2002, as to
    Lessee and this 31 day of July, 2002, as to Lessor.

    Signed and acknowledged           LESSOR: EWE WAREHOUSE INVESTMENTS V, LTD.
    in the presence of:                       BY MILLER-VALENTINE REALTY, INC.
                                              ITS MANAGING AGENT
/s/ Rita A Hughes
------------------
Rita A Hughes                         By:     /s/ Robert A. Gallinis
-------------                                 -------------------------------
Print Name                                    Robert A. Gallinis
                                      Title:  President
/s/ Kelli L. Wilson
-------------------
Kelli L. Wilson
---------------
Print Name

                                      LESSEE: MERRIMACK SERVICES CORPORATION dba
                                              PC CONNECTION SERVICES

/s/ Robert A. Pratt                   By:     /s/ Wayne L. Wilson
----------------------                        -------------------------------
Robert A. Pratt                               Wayne L. Wilson
Print Name                            Title:  President

/s/ Barbara J. Jaus
-------------------

Barbara J. Jaus
---------------
Print Name

<PAGE>

STATE OF OHIO, COUNTY OF MONTGOMERY, SS:

           The foregoing instrument was acknowledged before me this 31 day of
July, 2002, by Robert A. Gallinis,

President of MILLER-VALENTINE REALTY, INC.
                                             /s/ Rita A. Hughes
                                             -------------------
                                             NOTARY PUBLIC

                                             RITA A. HUGHES, Notary Public
                                             In and for the State of Ohio
                                             My Commission Expires May 4, 2006

STATE OF New Hampshire County of Hillsborough, SS:

           The foregoing instrument was acknowledged before me this 30 day of
July, 2002, by Wayne L. Wilson, the President of MERRIMACK SERVICES CORPORATION,
a corporation on behalf of said corporation.

                             /s/ Dolores R. Collins
                             ----------------------
                                  NOTARY PUBLIC

                                               DOLORES R. COLLINS, NOTARY PUBLIC
                                                                   NEW HAMPSHIRE
                                             My Commission Expires Jan. 20, 2004

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