Document:

EX-10.14

 Exhibit 10.14 

AGREEMENT BETWEEN BRANDT J. MANDIA AND 

PROTAGENIC THERAPEUTICS, INC. 

THIS AGREEMENT is made as of this 4th day of November, 2015, by and between Brandt
J. Mandia, an individual (“Consultant”), and Protagenic Therapeutics, Inc., a Delaware corporation (“Protagenic”). 

WHEREAS, Consultant has significant expertise in providing financial and business advisory services. 

WHEREAS, Consultant has been providing Protagenic with financial and business advisory services since January 2015. 

WHEREAS, Protagenic desires to retain Consultant to continue to provide it with these services, and to compensate Consultant for
services previously rendered, and Consultant is willing to be so retained, all on the terms set forth in this Agreement. 
 NOW
THEREFORE, in consideration of the mutual covenants of the parties set forth in this Agreement and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 

1. Term & Obligations The term of this Agreement shall extend until December 31, 2015. This Agreement may be extended by mutual
agreement of the parties. During the term of this Agreement, Consultant shall provide a variety of consulting and advisory services to Protagenic relating principally to identifying and evaluating strategic business relationships and strategies and
potential licensing opportunities. 
 3. Consideration to Consultant As full consideration for the services previously rendered
and to be rendered by Consultant hereunder, Protagenic hereby issues to Consultant a warrant (the “Warrant”) to purchase 200,000 shares of Protagenic common stock, par value $0.001 per share. The Warrant shall be exercisable for a
period of five years from the date of this agreement, at an exercise price of $1.25 per share. The Warrant shall be immediately vested as to 150,000 shares, and shall vest as to the remaining 50,000 shares on December 31, 2015. A form of the
Warrant is annexed hereto as Exhibit A. 
 4. Independent Contractor Status The parties intend for the relationship between Protagenic
and Consultant to be that of an independent contractor. Consultant shall be responsible for all income and other taxes imposed on Consultant under applicable law by reason of any consideration paid to consultant by Protagenic or any of its
affiliates pursuant to this Agreement. 

  
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 5. Confidential Information 

 

	 	i)	Company Information. At all times during the term of this Agreement and thereafter, Consultant shall hold in strictest confidence, and not use, except for the benefit of Protagenic and its affiliates, or
disclose to any person, firm or corporation without written authorization of the Board of Directors of the Protagenic, any Confidential Information of Protagenic or its affiliates. “Confidential Information” means any proprietary
information, technical data, trade secrets or know-how of Protagenic and its affiliates, including, but not limited to, research, product plans, products, services, customer lists and customers, markets, software, developments, inventions,
processes, formulas, technology, designs, drawings, engineering, hardware configuration information, marketing, finances or other business information disclosed to Consultant by Protagenic or its affiliates either directly or indirectly, in writing,
orally, by drawings, or by observation of parts or equipment. Confidential Information does not include any of the foregoing items that have become publicly known and made generally available through no wrongful act of Consultant or of others who
were under confidentiality obligations as to the item or items involved. 

  

	 	ii)	Consultant’s Information. At all times during the term of this Agreement and thereafter, Protagenic and its other consultants, directors, investors, shall hold in strictest confidence, and not use, or
disclose to any person, firm or corporation without written authorization of Consultant any Confidential Information of Consultant. Thus, “Confidential Information” also means any proprietary information, technical data, trade
secrets or know-how of Consultant, including, but not limited to, research, product plans, products, services, software, developments, inventions, processes, formulas, technology, designs, drawings, engineering, hardware configuration information,
marketing, disclosed to Protagenic and its other consultants, directors, investors, by Consultant either directly or indirectly, in writing, orally, by drawings, or by observation of parts or equipment. Confidential Information does not include any
of the foregoing items which has become publicly known and made generally available through no wrongful act of the Company or of others who were under confidentiality obligations as to the item or items involved. 

6. Separability of Terms Each obligation and consideration in this Agreement is separately enforceable and the parties’ requirements to
perform these obligations are separate and independent. In the event any provision, paragraph or clause either lapses in accordance with its terms or becomes unenforceable for any reason, all remaining provisions, paragraphs or clauses shall remain
in full force and effect. 
 7. Notices All notices or other communications hereunder shall be in writing and shall be deemed to have been duly
given if delivered personally or sent by telefax or email, by recognized overnight courier marked for overnight delivery, or by registered or certified mail, postage prepaid, address as follows: 

  
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 If to Consultant, to: 

Brandt J. Mandia 
 46 Lortel Avenue 

Staten Island, NY 10314 
 Tel: (917) 981-0235 

Email: dbncorpllc@yahoo.com 
 If to Protagenic, at: 

Protagenic Therapeutics, Inc. 
 149 Fifth Avenue, Suite 500 

New York, NY 10010 
 Attn: Garo H. Armen, PhD, Chairman 

Telefax: 212-994-8296 
 Telephone: 212-994-8201 

Email: armen@agenusbio.com 
 All such notices and communications
shall be effective, if by telefax, when receipt is confirmed by telephone, or if sent by nationally recognized overnight courier service, one business day after delivery to such courier service marked for overnight delivery, or, if mailed, when
received, or if e-mailed, upon confirmation of receipt. 
 9. Applicable Law This Agreement shall be governed by, and construed in accordance
with, the internal laws of the State of New York, without reference to or application of any conflicts of laws principles. 
 10. Accredited Investor
Status. Consultant represents and warrants that Consultant is an “accredited investor,” as such term is defined in Rule 501 of Regulation D under the Securities Act of 1933, as amended. 

11. Counterparts This Agreement may be executed in one or more counterparts, each of which shall be deemed an original, but all of which together
shall constitute one and the same instrument. 
 [signature page follows] 

  
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 IN WITNESS WHEREOF, the Parties have executed this Agreement as of the date first above written.

  

			
	CONSULTANT
	
	 /s/ Brandt J. Mandia

	Brandt J. Mandia
	
	PROTAGENIC THERAPEUTICS, INC.
		
	By:	 	 /s/ Garo H. Armen

		 	Garo H. Armen, PhD, Chairman

  
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 EXHIBIT A 

Form of Warrant 

  
 5EX-10.15

 Exhibit 10.15 
  

 
  

			
	 CONSULTANT:
 EFFECTIVE DATE:

TERMINATION DATE:
  
	  	 • Robert B. Stein
 • January 23,
2015
 • January 23, 2020
  

  

CONSULTING AGREEMENT 
 THIS CONSULTING
AGREEMENT (together with the Business Terms Exhibit, the “Agreement”) made as of January 23, 2015 (the “Effective Date”) is between Protagenic Therapeutics, Inc., a Delaware corporation with a office address at 149 5th Avenue, Suite 500, New York, NY 10010, Tel: 212 994 8202, F: 508 734 2177 (“Protagenic”) and Dr. Robert B. Stein having a home address at 155 Ocena Drive East, Suite 4i,
Brooklyn, NY 11235 (Tel: 650-283-5834) (“Consultant”). Protagenic desires to have the benefit of Consultant’s knowledge and experience, and Consultant desires to provide consulting services to Protagenic, all as provided in this
Agreement. 
  

	1.	Definitions. The following terms have the meanings set forth below: 

  

	 	1.1	“Business Terms Exhibit” means the business and financial terms applicable to the Consulting Services (as defined below) set forth in the attached exhibit, as may be amended from time to time by written
agreement of the parties. 

  

	 	1.2	“Confidential Information” means any non-public scientific, technical, financial or business information possessed or obtained by, developed for or given to Protagenic which is treated by Protagenic as
confidential or proprietary, whether or not labeled or identified as “Confidential”. Confidential Information will include, without limitation, information prepared in full or in part for Protagenic by Consultant, Materials and
Developments (defined below), the terms of this Agreement and information about or belonging to Protagenic’s suppliers, licensors, licensees, partners, affiliates, customers, potential customers or others. 

 

	 	1.3	“Developments” means concepts, inventions, know-how, techniques, improvements, writings, data, computer software, and Materials (whether or not patentable or subject to copyright or trade secret
protection) that Consultant makes, conceives or reduces to practice, either alone or jointly with others, and that result from the performance of the Consulting Services, and/or result from use of Protagenic’s Confidential Information.

  

	 	1.4	“Materials” means all materials furnished by Protagenic, all materials developed by Consultant in connection with the Consulting Services, and any materials, the cost of which are reimbursed to
Consultant by Protagenic hereunder. Materials include, in the case of biological materials, all progeny and unmodified derivatives of those materials, and in the case of chemical materials, all analogs, formulations, mixtures and compositions of
those materials. 

  

	 	1.5	“Term” means the term of this Agreement as set forth in the Business Terms Exhibit. 

  

	2.	Consulting Services. Protagenic retains Consultant and Consultant agrees to provide consulting services to Protagenic as it may from time to time reasonably request and as specified in the Business Terms
Exhibit (the “Consulting Services”). Any changes to the Consulting Services (and any related compensation adjustments) must be agreed to in writing between Consultant and Protagenic prior to commencement of the changes.

  

	3.	Consulting Relationship. Consultant agrees, as a condition of this Agreement, to the following terms: 

  

  
 Protagenic
Therapeutics Inc., 149 5th Avenue, Suite 500, New York, NY 10010, 
 Tel: 212 994
8202, F: 508 734 2177, www.protagenic.com 

  
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	 	3.1	Compliance. 

  

	 	a.	With Institution Policies. Protagenic recognizes that if the Consultant becomes a faculty member at or employee of a university or hospital (“Institution”), then the Consultant is responsible for
ensuring that any consulting agreement Consultant enters into with industry is not in conflict with the patent, consulting or other policies of Institution. If Consultant is required by Consultant’s Institution to disclose to it any proposed
agreements with industry, Consultant has made that disclosure. If Institution’s prior approval of this Agreement is required by Institution policies, Consultant has obtained that approval. 

 

	 	b.	With Policies and Regulations. In performing the Consulting Services, Consultant will comply with all business conduct, regulatory, and health and safety guidelines or regulations established by Protagenic or any
governmental authority with respect to State of Delaware’s business. 

  

	 	c.	Absence of Debarment. Consultant represents that Consultant has not been debarred, and to the best of Consultant’s knowledge, is not under consideration to be debarred, either by the Health Canada or by the
U.S. Food and Drug Administration from working in or providing services to any pharmaceutical or biotechnology company under the Generic Drug Enforcement Act of 1992. 

 

	 	3.2	Absence of Restrictions. Consultant is under no contractual or other obligation or restriction which is inconsistent with Consultant’s execution of this Agreement or the performance of the Consulting
Services. During the Term, Consultant will not enter into any agreement, either written or oral, in conflict with Consultant’s obligations under this Agreement. Consultant will arrange to provide the Consulting Services in such manner and at
such times so that they will not conflict with Consultant’s responsibilities under any other agreement, arrangement or understanding or pursuant to any employment relationship Consultant has at any time with any third party (including, without
limitation, Institution). 

  

	 	3.3	Confidential Information of Third Parties. The performance of the Consulting Services does not and will not breach any agreement which obligates Consultant to keep in confidence any confidential or proprietary
information of any third party or to refrain from competing, directly or indirectly, with the business of any third party. Consultant will not disclose to State of Delaware any confidential or proprietary information of any third parties.

  

	 	3.4	Competitive Activities. During the Term and for a period of twelve (12) months thereafter, Consultant will not provide consulting services to any business or entity developing a product or sponsoring a
project which competes with a product being developed or project being sponsored by Protagenic for which Consultant is providing Consulting Services. It will not be considered a competitive activity for Consultant to be a member of the faculty or
staff of a university, college or other educational or non-profit research institution. 

  

	4.	Compensation. As full consideration for the Consulting Services rendered under this Agreement, Protagenic agrees to pay Consultant and reimburse expenses as set forth in the Business Terms Exhibit.

  

	5.	Developments. 

  

	 	5.1	 Ownership. All Developments will be the exclusive property of Protagenic. All Developments that are “Works Made for Hire” as defined
both by the Canadian and the U.S. Copyright Act and other copyrightable works will be deemed, upon creation, to be assigned to Protagenic. Consultant will promptly and fully disclose to Protagenic all Developments. Consultant will keep and maintain

  
 Protagenic
Therapeutics Inc., 149 5th Avenue, Suite 500, New York, NY 10010, 
 Tel: 212 994
8202, F: 508 734 2177, www.protagenic.com 

  
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complete written records of all Developments and of all work or investigations done or carried out by Consultant. Consultant may keep one (1) copy of these records in Consultant’s files
solely for reference purposes. Consultant assigns and agrees to assign to Protagenic all of Consultant’s right, title and interest in and to any Developments. During and after the Term, Consultant will cooperate fully in obtaining patent and
other proprietary protection for the Developments, all in the name of Protagenic and at Protagenic’s cost and expense, and, without limitation, will execute and deliver all requested applications, assignments and other documents, and take such
other measures as Protagenic will reasonably request, in order to perfect and enforce Protagenic’s rights in the Developments. Consultant appoints Protagenic its attorney to execute and deliver any such documents on Consultant’s behalf in
the event Consultant fails to do so. 

  

	 	5.2	Agreement with Institution. This Agreement is made subject to the understanding that Consultant, if becoming an affiliated with an Institution, may be required to fulfill certain obligations, including teaching,
directing laboratory operations, conducting research, and publishing work. It is further understood that Consultant may have signed an agreement concerning inventions with Institution, under which Consultant may be obligated to assign to Institution
certain inventions which arise out of or otherwise relate to Consultant’s work at or for Institution or from Consultant’s use of certain of its facilities or intellectual property. In performing the Consulting Services, Consultant agrees
not to utilize Institution facilities or intellectual property if the result of that use is that any Development will not be assignable solely to Protagenic. 

  

	 	5.3	Work at Third Party Facilities. Unless covered by an appropriate agreement between any third party and Protagenic, Consultant will not engage in any activities or use any third party facilities or intellectual
property in performing the Consulting Services which could result in claims of ownership to any Developments being made by a third party. 

  

	6.	Confidentiality; Publication. 

  

	 	6.1	Confidentiality. During the Term and for a period of five (5) years thereafter, Consultant will not publish, disseminate or otherwise disclose, use for Consultant’s own benefit or for the benefit of a
third party, any Confidential Information. Consultant will exercise all reasonable precautions to physically protect the confidentiality of the Confidential Information. Consultant may disclose the Confidential Information to a governmental
authority or by order of a court of competent jurisdiction, provided that the disclosure is subject to all applicable governmental or judicial protection available for like material and reasonable advance notice is given to Protagenic. The
obligations of non-disclosure will not apply to information which (a) was known to Consultant at the time it was disclosed, other than by previous disclosure by Protagenic, as evidenced by Consultant’s written records at the time of
disclosure; (b) is at the time of disclosure or later becomes publicly known under circumstances involving no breach of this Agreement; or (c) is lawfully and in good faith made available to Consultant by a third party who did not derive
it, directly or indirectly, from Protagenic. 

  

	 	6.2	Publication. Consultant agrees to submit to Protagenic a copy of any proposed manuscript or other materials to be published or otherwise publicly disclosed which contain information or any discussion relating to
Protagenic or the Consulting Services, at least thirty (30) days prior to submission for publication or disclosure, to enable Protagenic to determine if patentable Developments or any Confidential Information of Protagenic would be disclosed.
Consultant will cooperate with Protagenic in this respect and will delete from the manuscript or other disclosure any Confidential Information if requested by Protagenic, and will assist Protagenic in filing for patent protection for any patentable
Developments described in those documents, prior to publication or other disclosure. 

  
 Protagenic
Therapeutics Inc., 149 5th Avenue, Suite 500, New York, NY 10010, 
 Tel: 212 994
8202, F: 508 734 2177, www.protagenic.com 

  
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	7.	Expiration/Termination. 

  

	 	7.1	Term. This Agreement will commence on the Effective Date and continue for the Term, unless sooner terminated pursuant to the express terms of this Section 7 or extended by mutual written agreement of the
parties. 

  

	 	7.2	Termination for Breach. If either party breaches in any material respect any of its material obligations under this Agreement, in addition to any other right or remedy, the non-breaching party may terminate this
Agreement in the event that the breach is not cured within thirty (30) days after receipt by that party of written notice of the breach. 

  

	 	7.3	Termination by Protagenic. Either party may terminate this Agreement (a) immediately at any time upon written notice to the other party in the event of a breach of this Agreement by the other party which
cannot be cured (i.e. breach of the confidentiality obligations) and/or (b) at any time without cause upon not less than fifteen (15) days’ prior written notice to the other party. 

 

	 	7.4	Effect of Expiration/Termination. Upon expiration or termination, neither Protagenic nor Consultant will have any further obligations under this Agreement, except (a) the liabilities accrued through the date
of expiration or termination, and (b) the terms and obligations under sections 1, 3.4, 5, 6, 7.4 and 8, will survive. Upon expiration or termination, and in any case upon Protagenic’s request, Consultant will promptly return to Protagenic
all Confidential Information and copies thereof, except for one (1) copy which Consultant may retain solely for archival purposes. 

  

	8.	Miscellaneous. 

  

	 	8.1	Independent Consultant; Taxes. 

  

	 	a.	Independent Consultant. All Consulting Services will be rendered by Consultant as an independent Consultant and this Agreement does not create an employer-employee relationship between Protagenic and Consultant.
Consultant will have no rights to receive any employee benefits, such as health and accident insurance, sick leave or vacation which are accorded to regular Protagenic employees. Consultant will not in any way represent himself to be an employee,
partner, joint venture, agent or officer with or of Protagenic. 

  

	 	b.	Taxes. Consultant will pay all required taxes on Consultant’s income from Protagenic under this Agreement. Consultant will provide Protagenic with Consultant’s taxpayer Identification Number or Social
Insurance number, as applicable. 

  

	 	8.2	Use of Name. Consultant consents to the use by Protagenic of Consultant’s name and likeness in written materials and oral presentations to current or prospective customers, partners, investors or others,
provided that the materials or presentations accurately describe the nature of Consultant’s relationship with or contribution to Protagenic. 

  

	 	8.3	Notices. All notices must be written and sent to the address or facsimile number identified in this Agreement or a subsequent notice. All notices must be given (a) by personal delivery, with receipt
acknowledged; (b) by facsimile followed by hard copy delivered by the methods under (c) or (d); (c) by prepaid certified or registered mail, return receipt requested; or (d) by prepaid recognized next business day delivery
service. Notices will be effective upon receipt or as stated in the notice. Notices to Protagenic must be marked “Attention: Chairman / CEO. 

  
 Protagenic
Therapeutics Inc., 149 5th Avenue, Suite 500, New York, NY 10010, 
 Tel: 212 994
8202, F: 508 734 2177, www.protagenic.com 

  
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	 	8.4	Assignment. This Agreement is a personal services agreement, and the rights and obligations hereunder, may not be assigned or transferred by either party without the prior written consent of the other party,
except that Protagenic may assign this Agreement, in whole or in part, to an affiliated company or in connection with the merger, consolidation, sale or transfer of all or substantially all of its business to which this Agreement relates.

  

	 	8.5	Entire Agreement. This Agreement constitutes the entire agreement of the parties with regard to its subject matter, and supersedes all previous written or oral representations, agreements and understandings
between Protagenic and Consultant. 

  

	 	8.6	No Modification. This Agreement may be changed only by a writing signed by both parties. 

  

	 	8.7	Severability. Each provision in this Agreement is independent and severable from the others, and no provision will be rendered unenforceable as a result of any other provision(s) being held to be invalid or
unenforceable in whole or in part. If any provision of this Agreement is invalid, unenforceable or too broad, that provision will be appropriately limited and reformed to the maximum extent permitted by applicable law. 

 

	 	8.8	Applicable Law. This Agreement will be governed by, and construed in accordance with, the laws of the State of Delaware, without regard to any choice of law principle that would dictate the application of the law
of another jurisdiction. Any action, suit, or other legal proceeding which is commenced to resolve any matter arising under or relating to any provision of this Agreement will be commenced only in a court of the State of Delaware (or, if
appropriate, a provincial court located within the State of Delaware), and Protagenic and Consultant each consents to the jurisdiction of such a court. 

  

	 	8.9	Counterparts. This Agreement may be executed in any number of counterparts, each of which when so executed and delivered shall be deemed to be an original, but all of which shall constitute one and the same
agreement. 

 IN WITNESS WHEREOF, duly authorized representatives of the parties have executed this Agreement as of the
Effective Date. 
  

							
	PROTAGENIC THERAPEUTICS, INC.	  	ROBERT B. STEIN
	By:	 		  		  	
				
	Signature:	 	 /s/ Robert Ziroyan
	  	Signature:	  	 /s/ Robert B. Stein

				
	Print Name:	 	Robert Ziroyan	  	SS or Tax ID No:	  	 [redacted]

				
	Title:	 	Interim President & Chief Operating Officer	  		  	

  
 Protagenic
Therapeutics Inc., 149 5th Avenue, Suite 500, New York, NY 10010, 
 Tel: 212 994
8202, F: 508 734 2177, www.protagenic.com 

  
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 BUSINESS TERMS EXHIBIT 

Consulting Agreement with Dr. Robert B. Stein 

1. Scope of Work/Duties and Responsibilities 
 Consultant
will provide advisory and technical services to Research and Development. 
 2. Compensation 

As full compensation for the Consulting Services, Protagenic will grant a nonqualified stock option to the Consultant under the terms and conditions specified
in the Nonqualified Stock Option Agreement. 
 3. Term: 

This agreement will be for a term of five years beginning of the Effective Date (the “Term”). 

4. Reporting: 
 The Consultant will be accountable to the
Chairman of Protagenic Therapeutics Inc. 

  
 Protagenic
Therapeutics Inc., 149 5th Avenue, Suite 500, New York, NY 10010, 
 Tel: 212 994
8202, F: 508 734 2177, www.protagenic.com 

  
 6

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