Document:

TARGACEPT, INC. 2000 EQUITY INCENTIVE PLAN AS AMENDED

 Exhibit 10.5 
  
 2000 EQUITY INCENTIVE PLAN 
  
 OF 
  
 TARGACEPT, INC. 
  
 Adopted as of:        
  
 August 22nd, 2000 
  

 2000 EQUITY INCENTIVE PLAN 
 OF 
 TARGACEPT, INC. 
  

	1.	Purpose 

  
 The purpose of the 2000 Equity Incentive Plan of Targacept, Inc. (the “Plan”) is to encourage and enable selected employees, directors,
independent contractors, consultants and advisors of Targacept, Inc. (the “Corporation”) and related corporations to acquire or to increase their holdings of common stock of the Corporation, $0.001 par value per share (the “Common
Stock”), and other proprietary interests in the Corporation in order to promote a closer identification of their interests with those of the Corporation and its stockholders, thereby further stimulating their efforts to enhance the efficiency,
soundness, profitability, growth and stockholder value of the Corporation. This purpose will be carried out through the granting of benefits (collectively referred to herein as “Awards”) to selected participants, including the granting of
incentive stock options (“Incentive Options”) intended to qualify under Section 422 of the Internal Revenue Code of 1986, as amended (the “Code”), nonqualified stock options (“Nonqualified Options”), stock appreciation
rights (“SARs”), stock awards in the form of bonus stock (“Bonus Stock”) and restricted stock awards (“Restricted Stock Awards”), and performance awards in the form of performance shares (“Performance Shares”)
and performance units (“Performance Units”). Incentive Options and Nonqualified Options shall be referred to herein collectively as “Options.” Bonus Stock and Restricted Stock Awards shall be referred to herein collectively as
“Stock Awards.” Performance Shares and Performance Units shall be referred to herein collectively as “Performance Awards.” 
  

	2.	Administration of the Plan 

  
 (a) The Plan shall be administered by the Board of Directors of the Corporation (the “Board”) unless the Board, in its sole discretion,
delegates all or part of its administrative authority with respect to the Plan to a committee of the Board (the “Committee”). For purposes herein, the Board, and, upon its delegation of the administrative responsibilities for the Plan to
the Committee, the Committee, shall be referred to as the “Administrator.” In the event that the Corporation shall become subject to the reporting requirements of the Securities Exchange Act of 1934, as amended (the “Exchange
Act”), the Committee shall be comprised solely of two or more “non-employee directors,” as said term is defined in Rule 16b-3 under the Exchange Act, unless the Board determines that such committee composition is not necessary or
advisable. Further, in the event that the Corporation becomes subject to the requirements of Section 162(m) of the Code, the Committee shall, unless the Board determines otherwise, be comprised solely of two or more “outside directors,” as
such term is defined under Section 162(m) or the regulations thereunder, or otherwise in accordance with Section 162(m) and such regulations. 
  
 (b) Any action of the Administrator with respect to the Plan may be taken by a written instrument signed by all of the members of the Board or Committee,
as appropriate, and any such action so taken by written consent shall be as fully effective as if it had been taken by a majority of the members at a meeting duly held and called. Subject to the provisions of the Plan, the Administrator shall have
full and sole authority in its discretion to take any action with respect to the Plan including, without limitation, the authority (i) to determine all matters relating to Awards, including selection of individuals to be granted Awards, the types of
Awards, the number of shares of the Common Stock, if any, subject to an Award, and all terms, conditions, restrictions and limitations of an Award and shares of Common Stock subject to an Award; (ii) to prescribe the form or forms of 

  

 
the agreements (as defined in Section 11) evidencing any Awards granted under the Plan; (iii) to establish, amend and rescind rules and regulations for the
administration of the Plan; and (iv) to construe and interpret the Plan and agreements evidencing Awards granted under the Plan, to establish and interpret rules and regulations for administering the Plan and to make all other determinations deemed
necessary or advisable for administering the Plan. The Administrator shall also have authority, in its sole discretion, to accelerate the date that any Award which was not otherwise exercisable or vested shall become exercisable or vested in whole
or in part without any obligation to accelerate such date with respect to any other Award granted to any recipient. In addition, the Administrator shall have the authority and discretion to establish terms and conditions of Awards as the
Administrator determines to be necessary or appropriate to conform to the applicable requirements or practices of jurisdictions outside of the United States. All determinations of the Administrator with respect to the Plan will be final and binding
on the Corporation and all persons having or claiming an interest in any Award granted under the Plan. No member of the Board or Committee, as applicable, shall be liable while acting as Administrator for any action or determination made in good
faith with respect to the Plan or any Award or agreement. 
  
 (c)
Notwithstanding the other provisions of Section 2, the Administrator may delegate to the Chief Executive Officer or President of the Corporation the authority to grant Awards, and to make any or all of the determinations reserved for the
Administrator in the Plan and summarized in Section 2(b) with respect to such Awards, to eligible individuals; provided, however, that, to the extent required by Section 16 of the Exchange Act or Section 162(m) of the Code, the individual, at the
time of said grant or other determination, (i) is not deemed to be an officer or director of the Corporation within the meaning of Section 16 of the Exchange Act; and (ii) is not deemed to be a covered employee (as defined in Section 21 (a)). To the
extent that the Administrator has delegated authority to grant Awards pursuant to this Section 2(c) to the Chief Executive Officer or President, references to the Administrator shall include references to such person, subject, however, to the
requirements of the Plan, Rule 16b-3 and other applicable law. 
  

	3.	Effective Date 

  
 The effective date of the Plan shall be August 22, 2000 (the “Effective Date”). Awards may be granted under the Plan on and after the Effective
Date, but no Awards will be granted after August 21, 2010. 
  

	4.	Shares of Stock Subject to the Plan; Award Limitations 

  
 (a) Subject to adjustment as provided in Section 4(c), the maximum number of shares of Common Stock that may be issued
pursuant to Awards shall not exceed 2,011,259 shares. To the extent required pursuant to Section 162(m) of the Code, during any 12-month period, (i) no Participant may receive shares of Common Stock pursuant to the grant of awards under the Plan for
more than 600,000 shares of Common Stock, and (ii) no Participant may receive awards under the Plan payable in cash having an aggregate dollar value in excess of $600,000, subject to adjustment as provided in Section 4(c) herein. Shares issued and
delivered under the Plan shall be authorized but unissued shares of the Corporation, treasury shares, or shares purchased on the open market or by private purchase. 
  
 (b) The Corporation hereby reserves sufficient authorized shares of Common Stock to meet the grant of Awards hereunder. Any
shares subject to an Award that is subsequently forfeited, expires or is terminated may again be the subject of an Award granted under the Plan. To the extent 

  

 
that any shares of Common Stock subject to an Award are not delivered to a Participant (or his beneficiary) because the Award is forfeited, canceled, settled
in cash, or used to satisfy applicable tax withholding obligations, such shares shall not be deemed to have been issued for purposes of determining the maximum number of shares of Common Stock available for issuance under the Plan. If the purchase
price of an Award granted under the Plan is satisfied by tendering or withholding shares of Common Stock, only the number of shares issued net of the shares of Common Stock tendered or withheld shall be deemed issued for purposes of determining the
maximum number of shares of Common Stock available for issuance under the Plan. 
  
 (c) If there is any change in the shares of Common Stock because of a reorganization, recapitalization, merger, consolidation, stock dividend, stock split, reverse stock split, subdivision, combination,
reclassification or other change in the capital stock structure of the Corporation or a related corporation affecting the Common Stock, the number of shares of Common Stock reserved for issuance under the Plan shall be correspondingly adjusted, and
the Administrator shall make such adjustments to Awards or to any provisions of this Plan as the Administrator deems equitable to prevent dilution or enlargement of Awards. 
  

	5.	Eligibility 

  
 An Award may be granted only to an individual who satisfies the following eligibility requirements on the date the Award is granted: 
  
 (a) The individual is either (i) an employee of the Corporation or a related
corporation, (ii) a director of the Corporation or a related corporation, or (iii) an independent contractor, consultant or advisor (collectively, “independent contractors”) providing bona fide services to the Corporation or a related
corporation not in connection with the offer and sale of securities in a capital-raising transaction. For this purpose, an individual shall be considered to be an “employee” only if there exists between the individual and the Corporation
or a related corporation the legal and bona fide relationship of employer and employee. 
  
 (b) With respect to the grant of Incentive Options, the individual is an employee who does not own, immediately before the time that the Incentive Option is granted, stock possessing more than ten percent of the total
combined voting power of all classes of stock of the Corporation. Notwithstanding the foregoing, an individual who owns more than ten percent of the total combined voting power of the Corporation may be granted an Incentive Option if the option
price (as determined pursuant to Section 6(b), is at least 110% of the fair market value of the Common Stock (as defined in Section 6(b)(ii)), and the option period (as defined in Section 6(c)(i)) does not exceed five years. For this purpose, an individual will be deemed to own stock which is attributable to him under Section 424(d) of the Code.

  
 (c) The individual, being otherwise eligible under this
Section 5, is selected by the Administrator as an individual to whom an Award shall be granted (a “Participant”). 
  

	6.	Options 

  
 (a) Grant of Options: Subject to the limitations of the Plan, the Administrator may in its sole and absolute discretion grant Options to such
eligible individuals in such numbers, upon such terms and at such times as the Administrator shall determine. Both Incentive Options and Nonqualified Options may be granted under the Plan; provided, however, that Incentive Options may 

  

 
only be granted to employees of the Corporation or a related corporation. To the extent that an Option is designated as an Incentive Option but does not
qualify as such under Section 422 of the Code, the Option (or portion thereof) shall be treated as a Nonqualified Option. 
  
 (b) Option Price: The price per share at which an Option may be exercised (the “option price”) shall be established by the Administrator
at the time the Option is granted and shall be set forth in the terms of the agreement evidencing the grant of the Option; provided that, (i) in no event shall the option price be less than the par value per share of the Common Stock; and (ii) in
the case of an Incentive Option, the option price shall be no less than 100% of the fair market value per share of the Common Stock on the date the Option is granted. In addition, the following rules shall apply: 
  
 (i) An Incentive Option shall be considered to be granted on
the date that the Administrator acts to grant the Option, or on any later date specified by the Administrator as the effective date of the Option. A Nonqualified Option shall be considered to be granted on the date the Administrator acts to grant
the Option or any other date specified by the Administrator as the date of grant of the Option. 
  
 (ii) For the purposes of the Plan, the “fair market value” per share of the Common Stock shall be determined in good faith by
the Administrator and, except as may otherwise be determined by the Administrator, fair market value shall be determined in accordance with the following provisions: (A) if the shares of Common Stock are listed for trading on the New York Stock
Exchange or the American Stock Exchange, the fair market value shall be the closing sales price of the shares on the New York Stock Exchange or the American Stock Exchange (as applicable) on the date immediately preceding the date the Option is
granted, or, if there is no transaction on such date, then on the trading date nearest preceding the date the Option is granted for which closing price information is available, and, provided further, if the shares are quoted on the Nasdaq National
Market or the NASDAQ SmallCap Market of the Nasdaq Stock Market, the fair market value shall be the closing sales price for such stock (or the average of closing bid and asked prices, if no sales were reported) as quoted on such system on the date
immediately preceding the date the Option is granted for which such information is available; or (B) if the shares of Common Stock are not listed or reported in any of the foregoing, then the fair market value shall be determined by the
Administrator in accordance with the applicable provisions of Section 20.2031-2 of the Federal Estate Tax Regulations, or in any other manner consistent with the Code and accompanying regulations. 
  
 (iii) In no event shall there first become exercisable by an
employee in any one calendar year Incentive Options granted by the Corporation or any related corporation with respect to shares having an aggregate fair market value (determined at the time an Incentive Option is granted) greater than $100,000;
provided that, if such limit is exceeded, then the first $100,000 of shares to become exercisable in such calendar year will be Incentive Options and the Options (or portion thereof) for shares with a value in excess of $100,000 that first became
exercisable in that calendar year will be Nonqualified Options. In the event the Code or the regulations promulgated thereunder are amended after the effective date of this Plan to provide for a different limit on the fair market value of shares
permitted to be subject to Incentive Options, then such different limit shall be automatically incorporated herein and will apply to any Incentive Option granted after the date of such amendment. 
  

 (c) Option Period and Limitations on the Right to Exercise Options 
  
 (i) The term of an Option (the “option period”)
shall be determined by the Administrator at the time the Option is granted. With respect to Incentive Options, such period shall not extend more than ten years from the date on which the Option is granted (unless otherwise limited by Section 5(b)).
Any Option or portion thereof not exercised before expiration of the option period shall terminate. The period or periods during which an Option may be exercised and other terms and conditions to exercise shall be determined by the Administrator.

  
 (ii) An Option may be exercised by giving
written notice to the Corporation at such place as the Administrator or its designee shall direct. Such notice shall specify the number of shares to be purchased pursuant to an Option and the aggregate purchase price to be paid therefor, and shall
be accompanied by the payment of such purchase price. Unless an individual option agreement provides otherwise, such payment may be in the form of cash or check, and, where expressly approved by the Administrator, payment may also be made:

  
 (A) By delivery (by either actual delivery or
attestation) of shares of Common Stock (valued at the date of exercise at their fair market value by the Administrator by applying the provisions of Section 6(b)(ii)) that have been owned by the Participant for more than six (6) months and are
otherwise acceptable to the Administrator; 
  
 (B) By withholding shares of Common Stock (valued at the date of exercise at their fair market value by the Administrator by applying the provisions of Section 6(b)(ii)) otherwise issuable upon exercise of the Option; 
  
 (C) With respect only to purchases upon exercise of an
Option after a public market for the Common Stock exists, by delivery of written notice of exercise to the Corporation and delivery to a broker of written notice of exercise and irrevocable instructions to promptly deliver to the Corporation the
amount of sale or loan proceeds to pay the option price; or 
  
 (D) By any combination of the foregoing. 
  
 For the purposes herein, a “public market” for the Common Stock shall be deemed to exist (i) upon consummation of a firm commitment underwritten public offering of the Common Stock pursuant to an effective
registration statement under the Securities Act of 1933, as amended (the “Securities Act”), or (ii) if the Administrator otherwise determines that there is an established public market for the Common Stock. 
  
 (iii) Unless an individual agreement provides otherwise, no
Option granted to a Participant who was an employee at the time of grant shall be exercised unless the Participant is, at the time of exercise, an employee as described in Section 5(a), and has been an employee continuously since the date the Option
was granted, subject to the following: 
  
 (A) An
Option shall not be affected by any change in the terms, conditions or status of the Participant’s employment, provided that the Participant continues to be an employee of the Corporation or a related corporation. 
  

 (B) The employment relationship of a Participant shall be treated as continuing intact
for any period that the Participant is on military or sick leave or other bona fide leave of absence, provided that the period of such leave does not exceed ninety days, or, if longer, as long as the Participant’s right to re-employment is
guaranteed either by statute or by contract. The employment relationship of a Participant shall also be treated as continuing intact while the Participant is not in active service because of disability. For purposes of the Plan,
“disability” shall have the meaning ascribed to the term in any stockholders agreement, employment agreement, consulting agreement or other similar agreement, if any, to which the Participant is a party, or if no such agreement applies,
“disability” shall mean the inability of the Participant to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to result in death, or which has lasted or
can be expected to last for a continuous period of not less than 12 months. The Administrator shall determine whether a Participant is disabled within the meaning of this paragraph, and, if applicable, the date of a Participant’s termination of
employment of service for any reason (the “termination date”). 
  
 (C) Unless an individual agreement provides otherwise, if the employment of a Participant is terminated because of disability within the meaning of subparagraph (B), or if the Participant dies while he is an employee
or dies within ninety (90) days after the termination of his employment because of disability, the Option may be exercised only to the extent exercisable on the date of the Participant’s termination date, except that the Administrator may in
its discretion accelerate the date for exercising all or any part of the Option which was not otherwise exercisable on the termination date. The Option must be exercised, if at all, prior to the first to occur of the following, whichever shall be
applicable: (X) the close of the period of one year next succeeding the termination date or such other time period as may be specified in the applicable agreement; or (Y) the close of the option period. In the event of the Participant’s death,
such Option shall be exercisable by such person or persons as shall have acquired the right to exercise the Option by will or by the laws of intestate succession. 
  
 (D) Unless an individual agreement provides otherwise, if the employment of the Participant is terminated
for any reason other than disability (as defined in subparagraph (B)), death or for “cause,” his Option may be exercised to the extent exercisable on the Participant’s termination date, except that the Administrator may in its
discretion accelerate the date for exercising all or any part of the Option which was not otherwise exercisable on the date of such termination of employment. The Option must be exercised, if at all, prior to the first to occur of the following,
whichever shall be applicable: (X) the close of the period of ninety (90) days next succeeding the termination date or such other time period as may be specified in the applicable agreement; or (Y) the close of the option period. If the Participant
dies following such termination of employment and prior to the earlier of the dates specified in (X) or (Y) of this subparagraph (D), the Participant shall be treated as having died while employed under subparagraph (C) immediately preceding
(treating for this purpose the Participant’s date of termination of employment as the termination date). In the event of the Participant’s death, such Option shall be 

  

 
exercisable by such person or persons as shall have acquired the right to exercise the Option by will or by the laws of intestate succession. 
  
 (E) Unless an individual agreement provides otherwise, if
the employment of the Participant is terminated for “cause,” his Option shall lapse and no longer be exercisable as of the effective time of his termination of employment, as determined by the Administrator. For purposes of the Plan, (X)
the Participant’s termination shall be for “cause” if such termination results from the Participant’s termination for “cause” under his employment, consulting or other agreement with the Corporation or a related
corporation, if any; or (Y) if the Participant has not entered into any such employment, consulting or other agreement, then the Participant’s termination shall be for “cause” if termination results due to the Participant’s (i)
dishonesty or conviction of a crime; (ii) failure to perform his duties for the Corporation or a related corporation to the satisfaction of the Corporation; or (iii) engaging in conduct that could be materially damaging to the Corporation without a
reasonable good faith belief that such conduct was in the best interest of the Corporation. The determination of “cause” shall be made by the Administrator and its determination shall be final and conclusive. 
  
 (F) Notwithstanding the foregoing, the Administrator shall
have authority, in its discretion, to extend the period during which an Option may be exercised or modify the other terms and conditions of exercise, or both; provided that, in the event that any such extension or modification shall cause an
Incentive Option to be designated as a Nonqualified Option, no such extension or modification shall be made without the written consent of the Participant. 
  
 (iv) Unless an individual agreement provides otherwise, an Option granted to a Participant who was a non-employee director of an
independent contractor of the Corporation or a related corporation at the time of grant (and who does not thereafter become an employee, in which case he shall be subject to the provisions of Section 6(c)(iii)) may be exercised only to the extent
exercisable on the date of the Participant’s termination of service to the Corporation or a related corporation (unless the termination was for cause), and must be exercised, if at all, prior to the first to occur of the following, as
applicable: (X) the close of the period of ninety (90) days next succeeding the termination date or such other time period as may be specified in the applicable agreement; or (Y) the close of the option period. If the services of such a Participant
are terminated for cause (as defined in Section 6(c)(iii)(E)), his Option shall lapse and no longer be exercisable as of the effective time of his termination of services, as determined by the Administrator. Notwithstanding the foregoing, the
Administrator may in its discretion accelerate the date for exercising all or any part of an Option which was not otherwise exercisable on the termination date, extend the period during which an Option may be exercised, modify the other terms and
conditions of exercise, or any combination of the foregoing. 
  
 (v) A Participant or his legal representatives, legatees or distributees shall not be deemed to be the holder of any shares subject to an Option and shall not have any rights as a stockholder unless and until
certificates for such shares are delivered to him or them under the Plan. 
  

 (vi) A certificate or certificates for shares of Common Stock acquired upon exercise of
an Option shall be issued in the name of the Participant (or his beneficiary) and distributed to the Participant (or his beneficiary) as soon as practicable following receipt of notice of exercise and payment of the purchase price. 
  
 (d) Nontransferability of Options 
  
 (i) Incentive Options shall not be transferable (including
by sale, assignment, pledge or hypothecation) other than by will or the laws of intestate succession. Nonqualified Options shall not be transferable (including by sale, assignment, pledge or hypothecation) other than by will or the laws of intestate
succession, except as may be permitted by the Administrator in its sole discretion in a manner consistent with the registration provisions of the Securities Act. Except as may be permitted by the preceding sentence, an Option shall be exercisable
during the Participant’s lifetime only by him or by his guardian or legal representative. The designation of a beneficiary does not constitute a transfer. 
  

(ii) If a Participant is subject to Section 16 of the Exchange Act, shares of Common Stock acquired upon exercise of an Option may not,
without the consent of the Administrator, be disposed of by the Participant until the expiration of six months after the date the Option was granted. 
  

	7.	Stock Appreciation Rights 

  
 (a) Grant of SARs: Subject to the limitations of the Plan, the Administrator may in its sole and absolute discretion grant SARs to such eligible
individuals, in such numbers, upon such terms and at such times as the Administrator shall determine. SARs may be granted to an optionee of an Option (hereinafter called a “Related Option”) with respect to all or a portion of the shares of
Common Stock subject to the Related Option (a “Tandem SAR”) or may be granted separately to an eligible key employee (a “Freestanding SAR”). Subject to the limitations of the Plan, SARs shall be exercisable in whole or in part
upon such terms and conditions as are provided in the agreement relating to the grant of the SAR. 
  
 (b) Tandem SARs: A Tandem SAR may be granted either concurrently with the grant of the Related Option or (if the Related Option is a Nonqualified
Option) at any time thereafter prior to the complete exercise, termination, expiration or cancellation of such Related Option. Tandem SARs shall be exercisable only at the time and to the extent that the Related Option is exercisable (and may be
subject to such additional limitations on exercisability as the Administrator may provide in the agreement), and in no event after the complete termination or full exercise of the Related Option. For purposes of determining the number of shares of
Common Stock that remain subject to such Related Option and for purposes of determining the number of shares of Common Stock in respect of which other Awards may be granted, upon the exercise of Tandem SARs, the Related Option shall be considered to
have been surrendered to the extent of the number of shares of Common Stock with respect to which such Tandem SARs are exercised. Upon the exercise or termination of the Related Option, the Tandem SARs with respect thereto shall be canceled
automatically to the extent of the number of shares of Common Stock with respect to which the Related Option was so exercised or terminated. Subject to the limitations of the Plan, upon the exercise of a Tandem SAR, the Participant shall be entitled
to receive from the Corporation, for each share of Common Stock with respect to which the Tandem SAR is being exercised, consideration equal in value to the excess of the fair market value of a share of Common Stock on the date of exercise over the
Related Option price per 

  

 
share; provided, that the Administrator may, in any agreement granting Tandem SARs, establish a maximum value payable for such SARs. 
  
 (c) Freestanding SARs: Unless an individual agreement provides
otherwise, the base price of a Freestanding SAR shall be not less than 100% of the fair market value of the Common Stock (as determined in accordance with Section 6(b)(ii)) on the date of grant of the Freestanding SAR. Subject to the limitations of
the Plan, upon the exercise of a Freestanding SAR, the Participant shall be entitled to receive from the Corporation, for each share of Common Stock with respect to which the Freestanding SAR is being exercised, consideration equal in value to the
excess of the fair market value of a share of Common Stock on the date of exercise over the base price per share of such Freestanding SAR; provided, that the Administrator may, in any agreement granting Freestanding SARs, establish a maximum value
payable for such SARs. 
  
 (d) Exercise of SARs:

  
 (i) Subject to the terms of the Plan, SARs
shall be exercisable in whole or in part upon such terms and conditions as are provided in the agreement relating to the grant of the SAR. The period during which an SAR may be exercisable shall not exceed ten years from the date of grant or, in the
case of Tandem SARs, such shorter option period as may apply to the Related Option. Any SAR or portion thereof not exercised before expiration of the period stated in the agreement relating to the grant of the SAR shall terminate. 
  
 (ii) SARs may be exercised by giving written notice to the
Corporation at such place as the Administrator shall direct. The date of exercise of the SAR shall mean the date on which the Corporation shall have received notice from the Participant of the exercise of such SAR. 
  
 (iii) No SAR may be exercised unless the Participant is, at
the time of exercise, an eligible Participant, as described in Section 5, and has been a Participant continuously since the date the SAR was granted, subject to the provisions of Sections 6(c)(iii) and (iv). 
  
 (e) Consideration: The consideration to be received upon the exercise
of the SAR by the Participant shall be paid in cash, shares of Common Stock (valued at fair market value on the date of exercise of such SAR in accordance with Section 6(b)(ii)) or a combination of cash and shares of Common Stock, as elected by the
Administrator, subject to the terms of the Plan and the applicable agreement. The Corporation’s obligation arising upon the exercise of the SAR may be paid currently or on a deferred basis with such interest or earnings equivalent (if any) as
the Administrator may determine. A certificate or certificates for shares of Common Stock acquired upon exercise of an SAR for shares shall be issued in the name of the Participant (or his beneficiary) and distributed to the Participant (or his
beneficiary) as soon as practicable following receipt of notice of exercise. No fractional shares of Common Stock will be issuable upon exercise of the SAR and, unless otherwise provided in the applicable agreement, the Participant will receive cash
in lieu of fractional shares. 
  
 (f) Limitations: The
applicable SAR agreement shall contain such terms, conditions and limitations consistent with the Plan as may be specified by the Administrator. Unless otherwise so provided in the applicable agreement or the Plan, any such terms, conditions or
limitations relating to a Tandem SAR shall not restrict the exercisability of the Related Option. 
  

 (g) Nontransferability: 
  
 (i) SARs shall not be transferable (including by sale, assignment, pledge or hypothecation) other than by
will or the laws of intestate succession (except to the extent, if any, that a Related Option is a Nonqualified Option and is transferable pursuant to Section 6(d)). The designation of a beneficiary does not constitute a transfer. SARs may be
exercised during the Participant’s lifetime only by him or by his guardian or legal representative. 
  
 (ii) If the Participant is subject to Section 16 of the Exchange Act, shares of Common Stock acquired upon exercise of an SAR may not,
without the consent of the Administrator, be disposed of by the Participant until the expiration of six months after the date the SAR was granted. 
  

	8.	Stock Awards 

  
 (a) Grant and Vesting of Stock Awards: Subject to the terms of the Plan, the Administrator may in its sole and absolute discretion grant Stock
Awards to such eligible individuals, for such numbers of shares, upon such terms and at such times as the Administrator shall determine. Stock Awards shall be payable in shares of Common Stock. The Administrator may grant Stock Awards in the form of
shares of Bonus Stock that vest immediately upon grant and that are not subject to any forfeiture conditions. The Administrator also may grant Stock Awards in the form of Restricted Stock Awards that are subject to certain conditions, which
conditions must be met in order for the Stock Award to vest and be earned (in whole or in part) and no longer subject to forfeiture. Such conditions may include but are not limited to continued service for a certain period of time, attainment of
performance objectives, retirement, displacement, disability, death, or a combination of these factors. Performance objectives may vary from Participant to Participant and between groups of Participants and shall be based on such corporate, business
unit and/or individual performance factors and criteria as the Administrator in its sole discretion may deem appropriate, which factors may include but are not limited to cash flow, return on equity, return on assets, total return to stockholders,
earnings per share, clinical development milestones, operations expense efficiency milestones or any combination of the foregoing. The Administrator also shall determine the nature, length and starting date, if any, during which a Stock Award may
vest (the “restriction period”). The Administrator shall have sole authority to determine whether and to what degree Stock Awards have vested and been earned and to establish and interpret the terms and conditions of Stock Awards and the
provisions herein. The Administrator shall also have authority, in its sole discretion, to accelerate the date that any Award which was not otherwise vested shall become vested in whole or in part without any obligation to accelerate such date with
respect to any other Award granted to any recipient. 
  
 (b)
Forfeiture of Stock Awards: Unless an individual agreement provides otherwise, if the employment or service of a Participant shall terminate for any reason and all or part of a Stock Award has not vested pursuant to the terms of the Plan and
related agreement, such Award, to the extent not then vested, shall be forfeited immediately upon such termination and the Participant shall have no further rights with respect thereto. 
  
 (c) Dividend and Voting Rights; Share Certificates: Unless an individual agreement provides otherwise, (i) a
Participant shall have no dividend rights, voting rights, or other rights as a stockholder with respect to shares subject to a Stock Award that has not yet vested and been earned; (ii) a certificate or certificates for shares of Common Stock subject
to a Stock Award shall be issued 

  

 
in the name of the Participant (or his beneficiary) and distributed to the Participant (or his beneficiary) as soon as practicable after the shares subject
to the Award shall be earned and vested; and (iii) no certificate shall be issued hereunder in the name of the Participant (or his beneficiary) except to the extent the shares represented thereby have been earned and vested. Notwithstanding the
foregoing, if the individual agreement provides that the shares subject to a Stock Award shall be issued prior to the vesting of the Award, the Corporation shall have the right to retain custody of the certificates evidencing the shares subject to
the Stock Award and to require the Participant to deliver to the Corporation a stock power, endorsed in blank, with respect to such Award. 
  
 (d) Nontransferability: 
  
 (i) Stock Awards that have not vested and been earned shall not be transferable (including by sale, assignment, pledge or hypothecation)
other than by will or the laws of intestate succession. The recipient of a Stock Award shall not sell, transfer, assign, pledge or otherwise encumber shares subject to the Award until the restriction period has expired and until all conditions to
vesting have been met. The transfer of shares subject to a Stock Award following vesting of the Award may be subject to such restrictions on transfer as may be imposed pursuant to Section 17 or pursuant to other restrictions established by the
Corporation. 
  
 (ii) If a recipient of a Stock
Award is subject to Section 16 of the Exchange Act, shares of Common Stock subject to such Award may not, without the consent of the Administrator, be sold or otherwise disposed of within six months following the date of grant of such Award.

  

	9.	Performance Awards 

  
 (a) Grant and Earning of Performance Awards: Subject to the terms of the Plan, Performance Awards in the form of either Performance Shares or
Performance Units, or a combination thereof, may be granted to Participants upon such terms and at such times as shall be determined by the Administrator. An award of Performance Shares is a grant of a right to receive shares of Common Stock or the
cash value thereof (or a combination thereof) which is contingent upon the achievement of performance or other objectives during a specified period. An award of Performance Units is a grant of a right to receive a designated dollar value amount of
Common Stock which is contingent upon the achievement of performance or other objectives during a specified period. Subject to Section 4(a), above, the Administrator shall have complete discretion in determining the number of Performance Units or
Performance Shares granted to each Participant. The Administrator shall determine the nature, length and starting date of the period during which a Performance Award may be earned (the “performance period”), and shall determine the
conditions which must be met in order for a Performance Award to be granted or to vest or be earned (in whole or in part), which conditions may include but are not limited to specified performance objectives, completion of the performance period, or
a combination of such conditions. The Administrator shall determine the performance objectives to be used in valuing Performance Awards and shall determine the extent, if any, to which such Awards have been earned. Performance objectives may vary
from Participant to Participant and between groups of Participants and shall be based oh such corporate, business unit and/or individual performance factors and criteria as the Administrator in its sole discretion may deem appropriate, which factors
may include but are not limited to cash flow, return on equity, return on assets, total return to stockholders, earnings per share, clinical development milestones, operations expense efficiency milestones or any combination of the foregoing. The

  

 
Administrator shall have sole authority to determine whether and to what degree Performance Awards have been earned and are payable and to interpret the
terms and conditions of Performance Awards and the provisions herein. The Administrator also shall determine the form and terms of payment of Performance Awards. The Administrator, in its sole and absolute discretion, may accelerate the date that
any Performance Award granted to a Participant shall be deemed to be earned in whole or in part, without any obligation to accelerate such date with respect to other Awards. 
  
 (b) Form of Payment: Payment of the amount to which a Participant shall be entitled upon earning a Performance Award
shall be made in cash, shares of Common Stock, or a combination of cash and shares of Common Stock, as determined by the Administrator in its sole discretion. Payment may be made in a lump sum or installments on such terms as may be established by
the Administrator. 
  
 (c) Forfeiture of Performance
Awards: Unless an individual agreement provides otherwise, if the employment or service of a Participant shall terminate for any reason and the Participant has not earned all or part of a Performance Award pursuant to the terms of the Plan and
related agreement, such Award, to the extent not then earned, shall be forfeited immediately upon such termination and the Participant shall have no further rights with respect thereto. 
  
 (d) Dividend and Voting Rights; Share Certificates: Unless an individual agreement provides otherwise, (i) a
Participant shall have no dividend rights, voting rights, or other rights as a stockholder with respect to shares, if any, subject to a Performance Award that has not yet been earned; (ii) a certificate or certificates for shares of Common Stock, if
any, subject to a Performance Award shall be issued in the name of the Participant (or his beneficiary) and distributed to the Participant (or his beneficiary) as soon as practicable after the Award has been earned; and (iii) no certificate shall be
issued hereunder in the name of the Participant (or his beneficiary) except to the extent that the Award has been earned. 
  
 (e) Nontransferability: 
  
 (i) Performance Awards which have not been earned shall not be transferable (including by sale, assignment, pledge or hypothecation) other
than by will or the laws of intestate succession. The recipient of a Performance Award shall not sell, transfer, assign, pledge or otherwise encumber any shares subject to the Award until the performance period has expired and until the conditions
to earning the Award have been met. The transfer of shares subject to a Performance Award following vesting of the Award may be subject to such restrictions on transfer as may be imposed pursuant to Section 17 or pursuant to other restrictions
established by the Corporation. 
  
 (ii) If a
recipient of a Performance Award is subject to Section 16 of the Exchange Act, shares of Common Stock, if any, subject to such Award may not, without the consent of the Administrator, be sold or otherwise disposed of within six months following the
date of grant of such Award. 
  

	10.	Withholding 

  
 Prior to the delivery of any certificate for shares or any other benefit conferred under the Plan, the Corporation shall require any recipient of an Award
to pay to the Corporation in cash the amount of any local, state or federal withholding tax or other amount required by any governmental 

  

 
authority to be withheld and paid over by the Corporation to such authority for the account of such recipient. Notwithstanding the foregoing, the
Administrator may, in its sole discretion, permit the recipient to satisfy such obligation in whole or in part, and any other local, state or federal income tax obligations relating to such an Award, by electing (the “election”) to have
the Corporation withhold shares of Common Stock from the shares to which the recipient is entitled. The number of shares to be withheld shall have a fair market value as of the date that the amount of tax to be withheld is determined as nearly equal
as possible to (but not exceeding) the amount of such obligations being satisfied. Each election must be made in writing to the Administrator in accordance with election procedures established by the Administrator. 
  

	11.	Agreement 

  
 The grant of any Award under the Plan shall be evidenced by the execution of an agreement (the “agreement”) between the Corporation and the
Participant. Such agreement shall state terms, conditions and restrictions applicable to the Award and any may state such other terms, conditions and restrictions, including but not limited to terms, conditions and restrictions applicable to shares
subject to an Award, as may be established by the Administrator. 
  

	12.	Code Section 162(m) Performance-Based Compensation Compliance 

  
 To the extent that Section 162(m) of the Code is applicable, the Administrator shall have discretion to determine the
extent, if any, that Awards conferred under the Plan to covered employees, as such term is defined in Section 21(a), are intended to comply with the qualified performance-based compensation exception to employer compensation deductions set forth in
Section 162(m) of the Code. 
  

	13.	Section 16(b) Compliance 

  
 To the extent that any Participants in the Plan are subject to Section 16(b) of the Exchange Act, it is the general intention of the Corporation that
transactions under the Plan shall comply with Rule 16b-3 under the Exchange Act and the Plan shall be construed in favor of the Plan transactions meeting the requirements of Rule 16b-3 or any successor rules thereto. If any Plan provision is later
found not to be in compliance with Section 16 of the Exchange Act, the provisions shall be deemed null and void. Notwithstanding anything in the Plan to the contrary, the Administrator, in its sole and absolute discretion, may bifurcate the Plan so
as to restrict, limit or condition the use of any provision of the Plan to participants who are officers or directors subject to Section 16 of the Exchange Act without so restricting, limiting or conditioning the Plan with respect to other
participants. 
  

	14.	No Right or Obligation of Continued Employment or Service 

  
 Nothing contained in the Plan shall confer upon a Participant the right to continue in the employment or service of the
Corporation or a related corporation as an employee, director or independent contractor or interfere in any way with the right of the Corporation or a related corporation to terminate the Participant’s employment or service at any time. Except
as otherwise provided in the Plan or a related agreement, (i) all rights of a Participant with respect to that portion of his Award which has not yet been exercised, vested or earned shall terminate upon termination of employment or service of the
Participant with the Corporation or a related corporation, and (ii) Awards granted under the Plan to a Participant shall not be affected by any change in the duties or position of the Participant, as long as such individual remains an employee of or
in service to the Corporation or a related corporation. 
  

	15.	Unfunded Plan; Not a Retirement Plan 

  
 (a) Neither a Participant nor any other person shall, by reason of the Plan, acquire any right in or title to any assets, funds or property of the
Corporation or any related corporation including, without limitation, any specific funds, assets or other property which the Corporation or any related corporation, in their discretion, may set aside in anticipation of a liability under the Plan. A
participant shall have only a contractual right to the Common Stock or amounts, if any, distributable or payable under the Plan, unsecured by any assets of the Corporation or any related corporation. Nothing contained in the Plan shall constitute a
guarantee that the assets of such corporations shall be sufficient to pay any benefits to any person. 
  
 (b) In no event shall any amounts accrued, distributable or payable under the Plan be treated as compensation for the purpose of determining the amount of
contributions or benefits to which any person shall be entitled under any retirement plan sponsored by the Corporation or a related corporation that is intended to be a qualified plan within the meaning of Section 401 (a) of the Code. 
  

	16.	Amendment and Termination of the Plan and Awards 

  

The Plan and any Award granted pursuant to the Plan may be amended or terminated at any time by the Board of Directors of the Corporation; provided,
that (i) amendment or termination of an Award shall not, without the consent of the recipient of an Award, adversely affect the rights of the recipient with respect to an outstanding Award; and (ii) approval of an amendment to the Plan by the
stockholders of the Corporation shall only be required in the event stockholder approval of any such amendment is required by applicable law, rule or regulation. 
  

	17.	Restrictions on Shares; Corporation’s Right of Repurchase 

  
 (a) The Administrator may impose such restrictions on Awards and any shares representing Awards hereunder as it may deem
advisable, including without limitation restrictions under the Securities Act, under the requirements of any stock exchange or similar organization and under any blue sky or state securities laws applicable to such shares. Notwithstanding any other
Plan provision to the contrary, the Corporation shall not be obligated to issue or deliver shares of Common Stock under the Plan or make any other distribution of benefits under the Plan, or take any other action, unless such delivery, distribution
or action is in compliance with all applicable laws, rules and regulations (including but not limited to the requirements of the Securities Act). The Corporation 

  

 
will be under no obligation to register shares of Common Stock with the Securities and Exchange Commission or to effect compliance with the exemption,
registration, qualification or listing requirements of any state securities laws, stock exchange or similar organization, and the Corporation will have no liability for any inability or failure to do so. The Corporation may cause a restrictive
legend to be placed on any certificate issued pursuant to an Award hereunder in such form as may be prescribed from time to time by applicable laws and regulations or as may be advised by legal counsel. 
  
 (b) As a condition to the issuance and delivery of Common Stock hereunder, or
the grant of any benefit pursuant to the terms of the Plan, and unless an individual agreement provides otherwise, the Corporation may require a Participant or other person to become a party to a stockholders agreement (including but not limited to
that certain Stockholders Agreement dated as of August 22, 2000, by and among Targacept, Inc. and its stockholders, as it may be amended), buy-sell agreement, redemption agreement, repurchase agreement or other agreement between the Corporation and
stockholders of the Corporation or among stockholders of the Corporation or such other agreements imposing such restrictions as may be required by the Corporation. 
  

	18.	Significant Transactions 

  
 Notwithstanding any other provision of the Plan to the contrary, and unless an individual agreement provides otherwise, in the event of a Significant
Transaction (as defined in Section 18(d)): 
  
 (a) All Options and
SARs outstanding as of the date of such Significant Transaction of shall become fully exercisable, whether or not then otherwise exercisable; 
  
 (b) Any restrictions including but not limited to the restriction period or performance period applicable to any Stock Award or Performance Award shall be
deemed to have expired, and such Awards shall become fully vested, earned and payable to the fullest extent of the original grant of the applicable Award; and 
  

(c) Notwithstanding the foregoing, in the event of a merger, share exchange, sale or disposal of substantially all of the assets of the Corporation,
reorganization or other business combination affecting the Corporation or a related corporation, the Administrator may, in its sole and absolute discretion, determine that any or all Awards granted pursuant to the Plan shall not vest, be earned or
become exercisable on an accelerated basis, if the Corporation or the surviving or acquiring corporation, as the case may be, shall have taken such action, including but not limited to the assumption of Awards granted under the Plan or the grant of
substitute awards (in either case, with substantially similar or equivalent terms as Awards granted under the Plan), as in the opinion of the Administrator is equitable or appropriate to protect the rights and interests of participants under the
Plan. For the purposes herein, if the Committee is acting as the Administrator, the Committee authorized to make the determinations provided for in this Section 18(c) shall be appointed by the Board of Directors, two-thirds of the members of which
shall have been directors of the Corporation prior to the sale, merger, share exchange, reorganization or other business combinations affecting the Corporation or a related corporation. 
  

 (d) For the purposes herein, a “Significant Transaction” shall be deemed to have occurred upon
the occurrence of any of the following: 
  
 (i)
The closing of a firm commitment underwritten public offering of the Corporation’s Common Stock pursuant to an effective registration statement under the Securities Act; 
  
 (ii) The date any entity or person that (A) does not beneficially own Common Stock as of the effective date
of the Plan and does not have any affiliate that beneficially owns Common Stock as of the effective date of the Plan shall have become the beneficial owner of, or shall have obtained voting control over, fifty percent (50%) or more of the
outstanding Common Stock of the Corporation or (B) beneficially owns Common Stock as of the effective date of the Plan or has one or more affiliates that beneficially own Common Stock as of the effective date of the Plan, together with its
affiliates, shall have become the beneficial owner of, or shall have obtained voting control over, sixty-seven percent (67%) or more of the outstanding Common Stock of the Corporation; or 
  
 (iii) The date the stockholders of the Corporation approve a
definitive agreement (X) to merge or consolidate the Corporation with or into another corporation, in which the Corporation is not the continuing or surviving corporation or pursuant to which any shares of Common Stock of the Corporation would be
converted into cash, securities or other property of another corporation, other than a merger or consolidation of the Corporation in which holders of Common Stock immediately prior to the merger or consolidation have the same proportionate ownership
of Common Stock of the surviving corporation immediately after the merger as immediately before, or (Y) to sell or otherwise dispose of all or substantially all the assets of the Corporation. 
  
 (For purposes herein, the term “person” shall mean any individual,
corporation, partnership, group, association or other person, as such term is defined in Section 13(d)(3) or Section 14(d)(2) of the Exchange Act, other than the Corporation, a subsidiary of the Corporation or any employee benefit plan(s) sponsored
or maintained by the Corporation or any subsidiary thereof, the term “affiliate” shall have the meaning given the term in Rule 12b-2 under the Exchange Act and the term “beneficial owner” shall have the meaning given the term in
Rule 13d-3 under the Exchange Act.) 
  

	19.	Applicable Law 

  
 The Plan shall be governed by and construed in accordance with the laws of the State of Delaware, without regard to the conflict of laws provisions of any
state. 
  

	20.	Stockholder Approval 

  
 The Plan is subject to approval by the stockholders of the Corporation, which approval must occur, if at all, within twelve (12) months of the effective
date of the Plan. Awards granted prior to such stockholder approval shall be conditioned upon and shall be effective only upon approval of the Plan by such stockholders on or before such date. 
  

	21.	Certain Definitions 

  
 For purposes of the Plan, the following terms shall have the meaning indicated unless otherwise provided herein: 
  
 (a) “Covered employee” shall have the meaning given the term in
Section 162(m) of the Code or the regulations thereunder. 
  
 (b)
“Parent” or “parent corporation” shall mean any corporation (other than the Corporation) in an unbroken chain of corporations ending with the Corporation if each corporation other than the Corporation owns stock possessing 50% or
more of the total combined voting power of all classes of stock in another corporation in the chain. 
  
 (c) “Predecessor” or “predecessor corporation” means a corporation which was a party to a transaction described in Section 424(a) of
the Code (or which would be so described if a substitution or assumption under that Section had occurred) with the Corporation, or a corporation which is a parent or subsidiary of the Corporation, or a predecessor of any such corporation.

  
 (d) “Related corporation” means any parent,
subsidiary or predecessor of the Corporation. 
  
 (e)
“Subsidiary” or “subsidiary corporation” means any corporation (other than the Corporation) in an unbroken chain of corporations beginning with the Corporation if each corporation other than the last corporation in the unbroken
chain owns stock possessing 50% or more of the total combined voting power of all classes of stock in another corporation in the chain. 
  
 IN WITNESS WHEREOF, this 2000 Equity Incentive Plan of Targacept, Inc., is, by the authority of the Board of Directors of the Corporation, executed in
behalf of the Corporation, effective the 22nd day of August, 2000. 
  

			
	TARGACEPT, INC.
		
	By:	 	 /s/ J. Donald deBethizy

	 	 	

	 	 	 J. Donald deBethizy, President

  

	
	 ATTEST:

	
	 /s/ August Borschke

	

	 Secretary

	
	 [Corporate Seal]

  

 Exhibit A 
  

2001 Declaration of Amendment to 
 2000 Equity Incentive Plan of Targacept, Inc. 
  
 THIS DECLARATION OF AMENDMENT is executed this 18th day of December, 2001, by TARGACEPT, INC., a Delaware
corporation (the “Company”), to the 2000 Equity Incentive Plan of Targacept, Inc. (the “Plan”). 
  
 R E C I T A L S: 
  
 WHEREAS, pursuant to Section 16 of the Plan, the Company’s Board of Directors and stockholders have approved the amendments to the Plan set forth below. 
  
 NOW, THEREFORE, IT IS DECLARED, that, effective as of the date hereof: 
  

	 	1.	Section 4(a) of the Plan is amended by deleting “2,011,259” therefrom and replacing it with “2,661,259.” 

  

	 	2.	Section 5 of the Plan is amended by deleting it in its entirety and replacing it with the following. 

  
 “5. Eligibility 
  
 An Award may be granted only to a person who satisfies the following eligibility requirements on the date the Award is granted:

  
 (a) The person is either (i) an employee of
the Corporation or a related entity, (ii) a director of the Corporation or a related entity, or (iii) an independent contractor, consultant or advisor (collectively, “independent contractors”) providing bona fide services to the
Corporation or a related entity not in connection with the offer and sale of securities in a capital raising transaction. For this purpose, an individual shall be considered to be an “employee” only if there exists between the individual
and the Corporation or a related entity the legal and bona fide relationship of employer and employee. 
  
 (b) With respect to the grant of Incentive Options, the person is an individual employee who does not own, immediately before the time
that the Incentive Option is granted, stock possessing more than ten percent of the total combined voting power of all classes of stock of the Corporation. Notwithstanding the foregoing, an individual who owns more than ten percent of the total
combined voting power of the Corporation may be granted an Incentive Option if the option price (as determined pursuant to Section 6(b), is at least 110% of the fair market value of the Common Stock (as defined in Section 6(b)(ii)), and 

 
the option period (as defined in Section 6(c)(i)) does not exceed five years. For this purpose, an individual will be deemed to own stock that is
attributable to him under Section 424(d) of the Code. 
  
 (c) The person, being otherwise eligible under this Section 5, is selected by the Administrator as a person to whom or to which an Award shall be granted (a “Participant”).” 
  

	 	3.	Each reference in the Plan to “individual” or “individuals,” when used to refer to a Participant(s) or a potential Participant(s) in the Plan (other than
references contained in Section 5, which are addressed above), shall be deemed to a reference to “person” or “persons.” 

  

	 	4.	Except as set forth herein, the Plan shall remain in full force and effect. 

  
 IN WITNESS WHEREOF, this Declaration of Amendment is executed on behalf of Targacept, Inc. as of the day and year first above written. 
  

			
	TARGACEPT, INC.
		
	By:	 	 /s/ J. Donald deBethizy

	 	 	

	 	 	 J. Donald deBethizy
 President and Chief Executive
Officer

  

 2 

 May 2002 Declaration of Amendment to 
 2000 Equity Incentive Plan of Targacept, Inc. 
  
 THIS MAY 2002 DECLARATION OF AMENDMENT is executed this 24th day of February 2003, effective as of May 15, 2002, by TARGACEPT, INC., a Delaware corporation (the “Company”), to the 2000 Equity Incentive Plan of Targacept, Inc., as amended (the
“Plan”). 
  
 RECITALS: 
  
 WHEREAS, pursuant to Section 16 of the Plan, the Company’s Board of
Directors has approved the amendment to the Plan set forth below. 
  
 NOW, THEREFORE, IT IS DECLARED, that, effective as of the date hereof: 
  

	 	5.	The first sentence of Section 8(d)(i) of the Plan is hereby amended to read: 

  

“Stock awards that have not vested and been earned shall not be transferable (including by sale, assignment, pledge or hypothecation) other than
by will or the laws of intestate succession, except as may be permitted by the Administrator in its sole discretion in a manner consistent with the registration provisions of the Securities Act.” 
  

	 	6.	Except as set forth herein, the Plan shall remain in full force and effect. 

  
 IN WITNESS WHEREOF, this Declaration of Amendment is executed on behalf of Targacept, Inc. as of the day and year first above written. 
  

			
	TARGACEPT, INC.
		
	By:	 	 /s/ J. Donald deBethizy

	 	 	

	 	 	 J. Donald deBethizy
 President and Chief Executive
Officer

 2002 Declaration of Amendment to 
 2000 Equity Incentive Plan of Targacept, Inc. 
  
 THIS 2002 DECLARATION OF AMENDMENT is executed this 26th day of November 2002, by TARGACEPT, INC., a Delaware corporation (the “Company”), to
the 2000 Equity Incentive Plan of Targacept, Inc., as amended (the “Plan”). 
  
 RECITALS: 
  
 WHEREAS, pursuant to
Section 16 of the Plan, the Company’s Board of Directors and stockholders have approved the amendments to the Plan set forth below. 
  
 NOW, THEREFORE, IT IS DECLARED, that, effective as of the date hereof: 
  

	 	1.	Section 4(a) of the Plan is amended by deleting “2,661,259” therefrom and replacing it with “5,661,259.” 

  

	 	2.	Except as set forth herein, the Plan shall remain in full force and effect. 

  
 IN WITNESS WHEREOF, this Declaration of Amendment is executed on behalf of Targacept, Inc. as of the day and year first above written. 
  

			
	TARGACEPT, INC.
		
	By:	 	 /s/ J. Donald deBethizy

	 	 	

	 	 	 J. Donald deBethizy

	 	 	 President and Chief Executive Officer

  

 EXHIBIT A 
  

2003 Declaration of Amendment to 
 2000 Equity Incentive Plan of Targacept, Inc. 
  
 THIS 2003 DECLARATION OF AMENDMENT is executed this 20th day of August 2003, by TARGACEPT, INC., a Delaware corporation (the “Company”), to the 2000 Equity Incentive Plan of Targacept, Inc., as amended (the “Plan”).

  
 RECITALS: 
  
 WHEREAS, pursuant to Section 16 of the Plan, the Company’s Board of
Directors have approved the amendments to the Plan set forth below. 
  
 NOW, THEREFORE, IT IS DECLARED, that: 
  

	 	1.	Section 4(a) of the Plan is amended, subject to approval of the Company’s stockholders, by deleting “5,661,259” therefrom and replacing it with “9,216,657.”

  

	 	2.	Section 18(d)(i) of the Plan is amended to read as provided below by incorporating therein the underlined language indicated below: 

  
 “The closing of a firm commitment underwritten public offering of the
Corporation’s Common Stock pursuant to an effective registration statement under the Securities Act (except that the foregoing shall not constitute a “Significant Transaction” with respect to Awards granted on and after August
20,2003);” 
  

	 	3.	Except as expressly modified herein, all of the terms of the Plan shall continue in full force and effect. 

  
 IN WITNESS WHEREOF, this Declaration of Amendment is executed on behalf of
Targacept, Inc. as of the day and year first above written. 
  

			
	TARGACEPT, INC.
		
	By:	 	 /s/ J. Donald deBethizy

	 	 	

	 	 	 J. Donald deBethizy

	 	 	 President and Chief Executive OfficerEMPLOYMENT AGREEMENT BETWEEN THE COMPANY AND J. DONALD DEBETHIZY

 Exhibit 10.7 
  
 EMPLOYMENT AGREEMENT 
  
 THIS EMPLOYMENT AGREEMENT (“Agreement”) is made as of August 22, 2000 by and between TARGACEPT, INC., a Delaware corporation
(“Employer”), and Dr. J. Donald deBethizy, an individual resident of North Carolina (“Employee”); 
  
 RECITALS: 
  
 WHEREAS, Employer considers the availability of Employee’s services to be important to the management and conduct of Employer’s business and
desires to secure the continued availability of Employee’s services; and 
  
 WHEREAS, Employee is willing to make his services available to Employer on the terms and subject to the conditions set forth herein; 
  
 NOW, THEREFORE, in consideration of the mutual covenants contained herein, the parties hereto agree as follows: 

 
 1. Employment. For the Term (as defined in Section 2),
Employee shall be employed as Chief Executive Officer and President. Employee will be located at the Employer’s principal executive offices in Winston-Salem, North Carolina. Employee hereby accepts and agrees to such employment, subject to the
general supervision of the Board of Directors of Employer (the “Board”). Employee shall perform such duties and shall have such powers, authority and responsibilities as are customary for one holding the position of President and Chief
Executive Officer of a business similar to Employer and shall additionally render such other services and duties as may be reasonably assigned to him from time to time by the Board. 
  
 2. Term of Employment. This Agreement shall commence as of September 15, 2000 (the “Effective Date”) and
continue until terminated as provided in Section 6 or Section 7 (such period, the “Term”). Any termination of this Agreement shall not affect the parties’ continuing obligations under Section 5, which shall survive any such
termination. 
  
 3. Compensation. 
  
 (a) For all services rendered by Employee to Employer under
this Agreement, Employer shall pay to Employee, during the Term, a base annual salary of not less than $225,000, payable in arrears in accordance with the customary payroll practices of Employer. During the Term, Employee’s annual base salary
shall be reviewed and subject to increase in accordance with Employer’s standard policies and procedures. Without limiting the generality of the foregoing, Employee’s base annual salary shall be increased annually to the extent necessary
to stay in line with the median base salary of employees of a similar level in comparable companies as described in the then current Radford Biotechnology Compensation Report. 
  
 (b) Employee shall be eligible to earn an annual bonus during the Term of up to 35% of Employee’s
annual base salary, or such higher amount as determined by 

  

 
the Board of Directors (or a compensation committee thereof). The eligibility for the target bonus shall be based upon the achievement of performance
objectives mutually agreed upon by Employee and Employer and shall be payable within thirty (30) days of the end of each fiscal year. 
  
 (c) All amounts payable hereunder shall be subject to such deductions and withholdings as shall be required by law, if any. 
  
 (d) Employee shall be issued 135,373 shares of
founder’s stock, which stock shall vest in accordance with the Stock Restriction Agreement attached hereto as Exhibit A. 
  
 (e) Employee shall be granted an incentive stock option to purchase 406,120 shares of Employer’s common stock under the terms of
Employer’s 2000 Equity Incentive Plan and pursuant to a form of option agreement attached hereto as Exhibit B (the “Option Agreement”). The incentive option shall have a term of ten years and an exercise price of $0.47 per
share and shall vest ratably over the twelve (12) quarters commencing twelve (12) months from the Effective Date. Any terms contained in this Agreement regarding the exercisability or vesting of such options, including without limitation this
Section 3(e) and Section 7, shall be reflected in the terms of the Option Agreement. Employee shall also be eligible to receive additional awards thereunder in the discretion of the Board (or a compensation committee thereof). 
  
 (f) Employee shall also be entitled to holidays, sick leave
and other time off and to participate in those life, health or other insurance plans and other employee pension and welfare benefit programs, plans, practices and benefits generally made available from time to time to all employees of Employer;
provided that nothing herein shall obligate Employer to continue any of such benefits for Employee if discontinued for other employees. Without limiting the foregoing, Employee shall be entitled to paid vacation during each fiscal year of the term
of twenty (20) days. 
  
 4. Reimbursement of Expenses.
Employer shall pay or reimburse Employee for all reasonable travel and other expenses incurred by Employee in performing his obligations under this Agreement and also, to the extent consistent with Employer’s policy, for any dues and costs of
appropriate professional organization and continuing professional education, in each case subject to such reasonable documentation and substantiation as Employer shall require. 
  
 5. Covenants of Employee. 
  

(a) Covenant Not to Compete. Employee covenants that during the “Noncompetition Period” (as defined in Section 5(g))
and within the “Noncompetition Area” (as defined in Section 5(h)), he shall not, directly or indirectly, as principal, agent, officer, director, shareholder, member, employee, consultant or trustee, or through the agency of any person,
firm, corporation, partnership, limited liability company, association or other entity (collectively, “Entity”), engage in the “Business” (as defined in Section 5(i)). Without limiting the generality of the foregoing, Employee
agrees that during the Noncompetition Period and within the 

  

 2 

 
Noncompetition Area, he shall not be (i) the owner of the outstanding capital stock or other equity interests of any Entity (other than Employer or its
affiliates) that, directly or indirectly, engages in the Business; or (ii) an officer, director, partner, manager, member, consultant or employee of any Entity that, directly or indirectly, engages in the Business; provided, that this Section 5(a)
shall not prevent Employee from (A) being an employee of any area or division of any Entity to the extent that such area or division does not, directly or indirectly, engage in the Business or (B) beneficially owning less than 1% of the stock of a
corporation traded on a national securities exchange or The Nasdaq National Market. 
  
 (b) Nondisclosure Covenant. The parties acknowledge that Employer and its affiliates are enterprises whose success is attributable
largely to the ownership, use and development of certain valuable confidential and proprietary information (the “Proprietary Information”), and that Employee’s employment with Employer will involve access to and work with such
information. Employee acknowledges that his relationship with Employer is a confidential relationship, and agrees that (i) he shall keep and maintain the Proprietary Information in strictest confidence, and (ii) he shall not, either directly or
indirectly, use any Proprietary Information for his own benefit, or divulge, disclose or communicate any Proprietary Information in any manner whatsoever to any person or Entity other than to employees or agents of Employer having a need to know
such Proprietary Information to perform their responsibilities on behalf of Employer, and to other persons or Entities in the normal course of Employer’s business. This nondisclosure obligation shall apply to all Proprietary Information,
whether or not Employee participated in the development thereof. Upon termination of his employment with Employer for any reason, Employee will return to Employer all Proprietary Information in any medium and all other documents, data, materials or
property of Employer (including any copies thereof) in his possession. For purposes of this Agreement, the term “Proprietary Information” shall include any and all proprietary information related to the business of Employer and its
affiliates and stockholders, or to any of their products, services, sales or operations, which is not generally known to the public, specifically including (but without limitation): trade secrets, processes, formulae, compounds and properties
thereof, data, files, research results, computer programs and related source codes and object codes, improvements, inventions, techniques, marketing plans, strategies, forecasts, copyrightable material, suppliers, methods and manner of operations;
information relating to the identity, needs and location of all past, present and prospective customers; and information with respect to the internal affairs of Employer and its affiliates. Such Proprietary Information may or may not contain legends
or other written notice that it is of a confidential or proprietary nature. The parties stipulate that, as between them, the above-described matters are important and confidential and gravely affect the successful conduct of the business of Employer
and its affiliates and that any breach of the terms of this Section 5(b) shall be a material breach of this Agreement. 
  
 (c) Nonsolicitation Covenant. Employee covenants that during the Noncompetition Period he shall not, directly or indirectly, on
behalf of himself or any Entity, call upon any of the customers or clients of Employer (or potential customers or clients whose business Employee solicited on behalf of Employer or about whose needs Employee gained information during his employment
with Employer) for the purpose of soliciting or providing any product or service similar to that provided by Employer, nor will he, in any way, directly or 

  

 3 

 
indirectly, on behalf of himself or any Entity solicit, divert or take away, or attempt to solicit, divert, or take away any of the customers, clients,
business or patrons of Employer (or potential customers or clients whose business Employee solicited on behalf of Employer or about whose needs Employee gained information during his employment with Employer). Employee further covenants that during
the Noncompetition Period he shall not, directly or indirectly, on behalf of himself or any Entity, solicit, induce or encourage any person to leave the employ of Employer. 
  
 (d) Inventions. All inventions, designs, formulae, processes, discoveries, drawings, improvements and
developments made by Employee, either solely or in collaboration with others, during his employment with Employer, whether or not during working hours, and relating to any methods, apparatus, products, compounds, services or deliverables which are
made, furnished, sold, leased, used or developed by Employer or its affiliates or which pertain to the Business (the “Developments”) shall become and remain the sole property of Employer. Employee shall disclose promptly in writing to
Employer all such Developments. Employee acknowledges and agrees that all Developments shall be deemed “works made for hire” within the meaning of the United States Copyright Act, as amended. If, for any reason, such Developments are not
deemed works made for hire, Employee hereby assigns to Employer all of his right, title and interest (including, but not limited to, copyright and all rights of inventorship) in and to such Developments. At the request and expense of Employer,
whether during or after employment with Employer, Employee shall make, execute and deliver all application papers, assignments or instruments, and perform or cause to be performed such other lawful acts as Employer may deem necessary or desirable in
making or prosecuting applications, domestic or foreign, for patents (including reissues, continuations and extensions thereof) and copyrights related to such Developments or in vesting in Employer full legal title to such Developments. Employee
shall assist and cooperate with Employer or its representatives in any controversy or legal proceeding relating to such Developments, or to any patents, copyrights or trade secrets with respect thereto. If for any reason Employee refuses or is
unable to assist Employer in obtaining or enforcing its rights with respect to such Developments, he hereby irrevocably designates and appoints Employer and its duly authorized agents as his agents and attorneys-in-fact to execute and file any
documents and to do all other lawful acts necessary to protect Employer’s rights in the Developments. Employee expressly acknowledges that the special foregoing power of attorney is coupled with an interest and is therefore irrevocable and
shall survive (i) his death or incompetency, (ii) the termination of his employment with Employer and (iii) the termination of this Agreement. 
  
 (e) Independent Covenants. Each of the covenants on the part of Employee contained in Sections 5(a), (b), (c) and (d) of this
Agreement shall be construed as an agreement independent of each other such covenant. The existence of any claim or cause of action of Employee against Employer, whether predicated on this Agreement or otherwise, shall not constitute a defense to
the enforcement by Employer of any such covenant. 
  
 (f) Reasonableness; Injunction. Employee acknowledges that his covenants contained in Section 5 of this Agreement are reasonably necessary for the protection of Employer and its affiliates and their businesses, and that such
covenants are reasonably limited with respect to the activities prohibited, the duration thereof, the geographic area thereof, the scope thereof and the effect thereof on Employee and the general public. Employee further 

  

 4 

 
acknowledges that violation of the covenants would immeasurably and irreparably damage Employer and its affiliates, and by reason thereof Employee agrees
that for violation or threatened violation of any of the provisions of this Agreement, Employer shall, in addition to any other rights and remedies available to it, at law or otherwise, be entitled to an injunction to be issued by any court of
competent jurisdiction enjoining and restraining Employee from committing any violation or threatened violation of this Agreement. Employee consents to the issuance of such injunction. Furthermore, Employer shall, in addition to any other rights or
remedies available to it, at law or otherwise, be entitled to reimbursement of court costs, attorneys’ fees and other expenses incurred as a result of a breach of this Agreement. Employee agrees to reimburse Employer for such expenses promptly
following a final determination that he has breached this Agreement. 
  
 (g) Noncompetition Period. “Noncompetition Period” shall mean the period commencing on the Effective Date and continuing until one year following termination of this Agreement. 
  
 (h) Noncompetition Area. The “Noncompetition
Area” shall consist of the entire world. 
  
 (i) Business. For the purposes of this Agreement, the “Business” shall mean the business of developing, manufacturing, marketing or selling therapeutic products that use synthetic nicotinic cholinergic compounds.

  
 6. Disability. Upon the “disability” of
Employee, this Agreement may be terminated by action of the Board upon 30 days prior written notice (the “Disability Notice”), such termination to become effective only if such disability continues. If, prior to the effective time of the
Disability Notice, Employee shall recover from such disability and return to the full-time active discharge of his duties, then the Disability Notice shall be of no further force and effect and Employee’s employment shall continue as if the
same had been uninterrupted. If Employee shall not so recover from his disability and return to his duties, then his services shall terminate at the effective time of the Disability Notice with the same force and effect as if that date had been the
end of the Term originally provided for hereunder. Such termination shall not prejudice any benefits payable to Employee that are fully vested as of the date of such termination. Prior to the effective time of the Disability Notice, Employee shall
continue to earn all compensation to which Employee would have been entitled as if he had not been disabled, such compensation to be paid at the time, in the amounts, and in the manner provided in Section 3(a). A “disability” of Employee
shall be deemed to exist at all times that Employee is considered by the insurance Employer which has issued any policy of disability insurance owned by Employer or for which premiums are paid by Employer (the “Employer Policy”) to be
totally disabled under the terms of such policy. In the event there is no Employer Policy, “disability” shall mean the inability, by reason of physical or mental incapacity, impairment or infirmity, of Employee to perform, upon request,
his regular duties required herein for six consecutive months, and the determination of the existence or nonexistence of disability shall be made by a medical doctor who is licensed to practice medicine in the State of North Carolina mutually
acceptable to the Board and to Employee (or, if Employee is incapacitated, his spouse). 
  

 5 

 7. Termination. 
  
 (a) If Employee shall die during the Term, this Agreement and the employment relationship hereunder will
automatically terminate on the date of death, which date shall be the last day of the Term; provided that such termination shall not prejudice any benefits payable to Employee or Employee’s beneficiaries that are fully vested as of the date of
death. 
  
 (b) Employer may terminate
Employee’s employment under this Agreement at any time with or without Just Cause. Any termination without Just Cause shall be effective only on thirty (30) days prior written notice to Employee. Any termination with Just Cause shall be
effective immediately or at such other time set by the Board. “Just Cause” shall mean (i) Employee’s willful and material breach of this Agreement and his continued failure to cure such breach to the reasonable satisfaction of the
Board within thirty (30) days following written notice of such breach to Employee from the Board; (ii) Employee’s conviction of, or entry of a plea of guilty or nolo contendere to a felony or a misdemeanor involving moral turpitude, (iii)
Employee’s willful commission of an act of fraud, breach of trust, or dishonesty including, without limitation, embezzlement, that results in material damage or harm to the business, financial condition or assets of Employer; or (iv)
Employee’s intentional damage or destruction of substantial property of Employer. Just Cause shall be determined by the Board in its reasonable discretion and the particulars of any determination shall be provided to Employee in writing. At any
time within ninety (90) days of receipt by Employee in writing of such determination, Employee may object to such determination in writing and submit the determination to arbitration in accordance with Section 9(j). If such determination is
overturned in arbitration, Employee will be treated as having been terminated without Just Cause and shall be entitled to the benefits of Section 7(d). 
  
 (c) Employee may voluntarily terminate his employment with Employer on thirty (30) days prior written notice to Employer. 
  
 (d) Upon any termination pursuant to this Section 7,
Employee shall be entitled to receive a lump sum equal to any base salary, target bonus and other compensation earned and due but not yet paid through the effective date of termination. In addition, if this Agreement and Employee’s employment
hereunder is terminated by (i) Employer (or its successor) other than for Just Cause, or (ii) Employee for Good Reason, Employee shall be entitled to the following: 
  
 (A) severance, payable monthly, equal to Employee’s then current base salary for twelve (12) months
following such termination or, if shorter, until such time as Employee secures other employment (the “Severance Period”). 
  
 (B) twelve (12) months acceleration of unvested stock options to purchase capital stock or restricted stock of the Employer held by
Employee; 
  
 (C) the health care (including
medical and dental) and life insurance benefits coverage provided to Employee at his date of termination shall be continued at the same level and in the same manner as if his employment had not terminated (subject to the 

  

 6 

 
customary changes in such coverages if Employee reaches age 65 or similar events), for the Severance Period, followed by COBRA election rights. Any
additional coverages Employee had at termination, including dependent coverage, will also be continued for such period on the same terms. Any costs Employee was paying for such coverages at the time of termination shall continue to be paid by
Employee. If the terms of any benefit plan referred to in this section do not permit continued participation by Employee, then Employer will arrange for other coverage providing substantially similar benefits at the same contribution level of
Employee, and 
  
 (D) outplacement counseling
services selected by Employee, up to a maximum of $10,000. 
  
 (e) If Employer (or its successor) terminates Employee’s employment for Just Cause, Employee shall forfeit any unexercised vested stock options at the date of termination. If Employee terminates his employment or
if Employer (or its successor) terminates Employee’s employment without Just Cause, Employee shall have ninety (90) days from the date of termination to exercise any vested options. 
  
 (f) For purposes hereof, “Good Reason” shall mean the occurrence of any of the following events
without Employee’s express written consent: 
  
 (A) the breach by Employer (or any successor entity) of any material provision of this Agreement; 
  
 (B) any purported termination of the employment of Employee by Employer (or any successor entity) which is not effected in accordance
with this Agreement;. 
  
 (C) any failure of the
Employer (or any successor entity) to pay Employee and amounts of base salary or bonus compensation that have become due and payable to Employee within thirty (30) days after Employee has given Employer (or any successor entity) notice of demand
therefor. 
  
 Notwithstanding the foregoing, Employee expressly acknowledges and
agrees that the hiring by Employer of a new Chief Executive Officer shall not constitute Good Reason so long as Employee retains the office of President, Chief Operating Officer or comparable executive management title of Employer. 
  
 (g) Except as otherwise provided in this Section 7, upon
termination of this Agreement for any reason, Employee shall not be entitled to any form of severance benefits, including benefits otherwise payable under any of Employer’s regular severance plans or policies, or any other payment whatsoever.
Employee agrees that the payments and benefits provided hereunder, subject to the terms and conditions hereof shall be in full satisfaction of any rights which he might otherwise have or claim by operation of law, by implied contract or otherwise,
except for rights which he may have under any employee benefit plan of Employer. 
  

 7 

 8. Best Efforts of Employee. Employee agrees that he will at all times faithfully, industriously
and to the best of his ability, experience and talents perform all the duties that may be required of him pursuant to the express and implicit terms hereof, to the reasonable satisfaction of Employer, commensurate with his position. Such duties
shall be rendered at such place as Employer designates and employee acknowledges that he may be required to travel as shall reasonably be required to promote the business of Employer. To the extent reasonably required by the duties assigned to him,
Employee shall devote substantially all his time, attention, knowledge and skills to the business and interest of Employer and shall be entitled to all the benefits, profits and other issue arising from or incident to all work, service and advice of
Employee. During the Term, Employee shall not be interested, directly or indirectly, in any manner as partner, manager, officer, director, shareholder, member, adviser, consultant, employee or in any other capacity in any other business; provided,
that nothing herein contained shall be deemed to prevent or limit the right of Employee to beneficially own less than 1% of the stock of a corporation traded on a national securities exchange or The Nasdaq National Market as long as such passive
investment does not interfere with or conflict with the performance of services to be rendered hereunder. Notwithstanding the foregoing, Employer expressly acknowledges and agrees that, if requested by RJRT, Employee may, at any time within six (6)
months after the date hereof, testify, give depositions and spend reasonable time preparing for same in those cases involving RJRT set forth below: 
  
 Jones vs. R. J. Reynolds Tobacco Co., et al., Circuit Court, Hillsborough County, Tampa, FL 
 Davis vs. Philip Morris, Inc., et al., Supreme Court, Kings County, Brooklyn, NY 
 Little vs. R. J. Reynolds
Tobacco Co., et al., U.S. District Court, Charleston, SC 
 Blankenship vs. Philip Morris, Inc., et al., Circuit Court, Ohio County, Wheeling, WV

 Falise vs. Philip Morris, Inc., et al., U.S. District Court, Eastern District, Brooklyn, NY 
 Blue Cross and Blue Shield of New Jersey vs. Philip Morris, Inc., et al., U.S. District Court, Eastern District, Brooklyn, NY 
 Seaborn vs. R. J. Reynolds Tobacco Co., et al., Circuit Court, Barbour County, Clayton, AL 
 Thomas vs. Philip Morris, Inc., et al., Circuit Court, Jefferson County, Fayette, MS 
  
 9. Miscellaneous. 
  
 (a) This Agreement shall be governed by and construed in accordance with the laws of the State of North Carolina without regard to
conflicts of law principles thereof. 
  
 (b) This
Agreement constitutes the entire Agreement between Employee and Employer with respect to the subject matter hereof, and supersedes in their entirety any and all prior oral or written agreements, understandings or arrangements between Employee and
Employer or any of its affiliates relating to the terms of Employee’s employment by Employer, and all such agreements, understandings and arrangements are hereby terminated and are of no force and effect. Employee hereby expressly disclaims any
rights under any such agreements, understandings and arrangements. This Agreement may not be amended or terminated except by an agreement in writing signed by both parties. 
  
 (c) This Agreement may be executed in two or more counterparts, each of which shall be deemed and original
and all of which, taken together, shall constitute one and the same instrument. 
  

 8 

 (d) Any notice or other communication required or permitted under this Agreement shall be
effective only if it is in writing and delivered in person or by nationally recognized overnight courier service or deposited in the mails, postage prepaid, return receipt requested, addressed as follows: 
  
 To Employer: 
  
 Targacept, Inc. 
 Bowman Gray Technical Center 
 950 Reynolds Boulevard 
 Winston-Salem, North Carolina 27105 
 Attn: President 
  
 To Employee: 
  
 Dr. J. Donald deBethizy 
 2519 Woodbine Road 
 Winston-Salem, NC 27104 
  
 Notices given in person or by overnight courier service shall be deemed given when delivered in person or the day after delivery to the
courier addressed to the address required by this Section 9(d), and notices given by mail shall be deemed given three days after deposit in the mails. Any party hereto may designate by written notice to the other party in accordance herewith any
other address to which notices addressed to him shall be sent. 
  
 (e) The provisions of this Agreement shall be deemed severable and the invalidity or unenforceability of any provision shall not affect the validity or enforceability of the other provisions hereof. It is understood
and agreed that no failure or delay by Employer or Employee in exercising any right, power or privilege under this Agreement shall operate as a waiver thereof, nor shall any single or partial exercise thereof preclude any other or further exercise
thereof or the exercise of any other right, power or privilege hereunder. 
  
 (f) This Agreement may not be assigned by Employee without the written consent of Employer. This Agreement shall be binding on any successors or assigns of either party hereto. 
  
 (g) For purposes of this Agreement, employment of Employee
by any affiliate of Employer shall be deemed to be employment by Employer hereunder, and a transfer of employment of Employee from one such affiliate to another shall not be deemed to be a termination of employment of Employee by Employer or a
cessation of the Term, it being the intention of the parties hereto that employment of Employee by any affiliate of Employer shall be treated as employment by Employer and that the provisions of this Agreement shall continue to be fully applicable
following any such transfer. 
  

 9 

 (h) The respective rights and obligations of the parties hereunder shall survive any
termination of the Term or Employee’s employment with Employer to the extent necessary to preserve such rights and obligations for their stated durations. 
  

(i) In the event that it shall become necessary for either party to retain the services of an attorney to enforce any terms under this
Agreement, the prevailing party, in addition to all other rights and remedies hereunder or as provided by law, shall be entitled to reasonable attorneys’ fees and costs of suit. Employer shall reimburse Employee for the reasonable fees and
expenses of counsel to Employee for the original negotiation of this Agreement. 
  
 (j) Any controversy or claim arising out of or relating to this Agreement shall be settled by arbitration in accordance with Commercial
Arbitration Rules of the American Arbitration Association, and judgment upon the award rendered by the arbitration panel, which shall consist of three members, may be entered in any court having jurisdiction. Any arbitration shall be held in
Winston-Salem, North Carolina, unless otherwise agreed in writing by the parties. One arbitrator shall be selected by Employee, one arbitrator shall be selected by Employer, and the third arbitrator shall be selected by the two arbitrators selected
by Employee and Employer. 
  
 [THE NEXT PAGE IS THE SIGNATURE PAGE]

  

 10 

 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date and year first above
written. 
  

			
	TARGACEPT, INC.
		
	By:	 	 /s/ J. Donald deBethizy

	 	 	

	 Name:
	 	 J. Donald deBethizy

	 Title:
	 	 President

  

	
	EMPLOYEE:
	
	 /s/ J. Donald deBethizy

	

	 Dr. J. Donald deBethizy

  

 11 

 EXHIBIT A 
  
 OPTION AGREEMENT 
  

 2000 EQUITY INCENTIVE PLAN 
 OF 
 TARGACEPT, INC. 
  
 Stock Option Agreement 
 (Employees) 
  
 THIS AGREEMENT (the “Agreement”), made the 22nd day of August, 2000, between Targacept, Inc., a Delaware corporation (the
“Corporation”), and J. Donald deBethizy, an employee of the Corporation or a related corporation (the “Participant”), effective as of September 15, 2000; 
  
 R E C I T A L S : 
  
 In furtherance of the purposes of the 2000 Equity Incentive Plan of
Targacept, Inc., as it may be hereafter amended (the “Plan”), and in consideration of the services of the Participant and such other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the
Corporation and the Participant hereby agree as follows: 
  
 1.
Incorporation of Plan. The rights and duties of the Corporation and the Participant under this Agreement shall in all respects be subject to and governed by the provisions of the Plan, a copy of which is delivered herewith or has been
previously provided to the Participant and the terms of which are incorporated herein by reference. In the event of any conflict between the provisions in. the Agreement and those of the Plan, the provisions of the Plan shall govern. Unless
otherwise defined herein, capitalized terms in this Agreement shall have the same definitions as set forth in the Plan. 
  
 2. Grant of Option; Term of Option. The Corporation hereby grants to the Participant pursuant to the Plan, as a matter of separate inducement and
agreement in connection with his employment or service to the Corporation, and not in lieu of any salary or other compensation for his services, the right and Option (the “Option”) to purchase all or any part of an aggregate of four
hundred six thousand one hundred twenty (406,120) shares (the “shares”) of the common stock (the “Common Stock”) of the Corporation, at a purchase price (the “option price”) of forty-seven cents ($0.47) per share. The
Option to purchase four hundred six thousand one hundred twenty (406,120) of the shares shall be designated as an Incentive Option. To the extent that the Option is designated as an Incentive Option and such Option does not qualify as an Incentive
Option, the Option (or portion thereof) shall be treated as a Nonqualified Option. Except as otherwise provided in the Plan, the Option will expire if not exercised in full before September 15, 2010. 
  
 3. Exercise of Option. The Option shall become exercisable on the date
or dates and subject to such conditions set forth on Schedule A attached hereto; provided, that, as permitted by the Plan, the terms of Section 18(c) of the Plan shall not apply to the Option. To the extent that the Option is exercisable but is not
exercised, the Option shall accumulate and be exercisable by the Participant in whole or in part at any time prior to expiration of the Option, 

  

 
subject to the terms of the Plan and this Agreement. Upon the exercise of an Option in whole or in part and payment of the option price in accordance with
the provisions of the Plan and this Agreement, the Corporation shall as soon thereafter as practicable deliver to the Participant a certificate or certificates for the shares purchased. Payment of the option price may be made: (i) in cash or by
check; (ii) by delivery (by either actual delivery or attestation) of shares of Common Stock owned by the Participant at the time of exercise for a period of at least six months and otherwise acceptable to the Administrator; (iii) by withholding
shares of Common Stock otherwise issuable upon exercise of the Option; (iv) in the event that a public market for the Common Stock exists (as defined in the Plan), by delivery of written notice of exercise to the Corporation and delivery to a broker
of written notice of exercise and irrevocable instructions to promptly deliver to the Corporation the amount of sale or loan proceeds to pay the option price; (v) by such other methods as may be permitted by the Administrator in accordance with
Section 6(c)(ii) of the Plan; or (vi) by a combination of the foregoing methods. Shares delivered or withheld in payment of the option price shall be valued at their fair market value on the date of exercise, as determined by the Administrator by
applying the provisions of the Plan. 
  
 4. No Right of
Continued Employment or Service. Nothing contained in this Agreement or the Plan shall confer upon the Participant any right to continue in the employment or service of the Corporation or a related corporation or interfere with the right of the
Corporation or a related corporation to terminate the Participant’s employment or service at any time. Except as otherwise expressly provided in the Plan, all rights of the Participant under the Plan with respect to the unexercised portion of
his Option shall terminate upon termination of the employment or service of the Participant with the Corporation or a related corporation. 
  
 5. Nontransferability of Option. The Option shall not be transferable other than by will or the laws of intestate succession. Except as may be
permitted by the preceding sentence, this Option shall be exercisable during the Participant’s lifetime only by the Participant. 
  
 6. Superseding Agreement; Binding Effect. This Agreement supersedes any statements, representations or agreements of the Corporation with respect
to the grant of the Option or any related rights, and the Participant hereby waives any rights or claims related to any such statements, representations or agreements. This Agreement shall be binding upon and shall inure to the benefit of the
parties hereto and their respective executors, administrators, next-of-kin, successors and assigns. 
  
 7. Representations and Warranties of Participant. The Participant represents and warrants to the Corporation that: 
  

	 	(a)	Agrees to Terms of the Plan and Agreement. The Participant has received a copy of the Plan, has read and understands the terms of the Plan and this Agreement, and agrees to
be bound by their terms and conditions. The Participant acknowledges that there may be adverse tax consequences upon acquisition or disposition of the shares subject to the Option, and that Participant should consult a tax advisor prior to such
exercise or disposition. 

  

	 	(b)	Purchase for Own Account for Investment. Any shares of Common Stock acquired pursuant to the Option shall be acquired for Participant’s own account for investment
purposes only and not with a view to, or for sale in connection with, a distribution of the shares within the meaning of the Securities Act of 1933, as amended (the “Securities Act”). The Participant has no present intention of selling or
otherwise disposing of all or any portion of the shares subject to the Option. 

  

	 	(c)	Access to Information. The Participant has had access to all information regarding the Corporation and its present and prospective business, assets, liabilities and financial
condition that the Participant reasonably considers important in making a decision to acquire the shares subject to the Option, and the Participant has had ample opportunity to ask questions of the Corporation’s representatives concerning such
matters and this investment. 

  

	 	(d)	Understanding of Risks. The Participant is fully aware of: (i) the speculative nature of the investment in the shares of Common Stock; (ii) the financial hazards involved in
investment of the Common Stock; (iii) the lack of liquidity of the shares subject to the Option and the restrictions on transferability of such shares; (iv) the qualifications and backgrounds of the management of the Corporation; and (v) the tax
consequences of investment in the shares of Common Stock. The Participant is capable of evaluating the merits and risks of this investment, has the ability to protect his own interests in this transaction and is financially capable of bearing a
total loss of this investment. 

  

	 	(e)	No General Solicitation. At no time was the Participant presented with or solicited by any publicly issued or circulated newspaper, mail, radio, television or other form of
general advertising or solicitation in connection with the offer, sale and purchase of the shares subject to the Option. 

  

	 	(f)	Compliance with Securities Laws. The shares subject to the Option have not been registered with the Securities and Exchange Commission (“SEC”) under the Securities
Act and, notwithstanding any other provision of this Agreement or the Plan to the contrary, the right to acquire any shares subject to this Option is expressly conditioned upon compliance with the Securities Act and all applicable state securities
laws. The Participant agrees to cooperate with the Corporation to ensure compliance with such laws. 

  

	 	(g)	 No Transfer Unless Registered or Exempt. The Participant understands that he may not transfer any shares subject to the Option unless such shares are
registered under the Securities Act or qualified under applicable state securities laws or unless, in the opinion of counsel to the Corporation, exemptions from such registration and qualification requirements are available. The Participant
understands that only the Corporation may file a registration statement with the SEC and that the Corporation is under no obligation to do so with respect to the shares subject to the Option. The Participant has also been advised that 

  

	 	 
exemptions from registration and qualification may not be available or may not permit the Participant to transfer all or any of the shares subject to the
Option in the amounts or at the times proposed by him. The Participant also agrees in connection with any registration of the Corporation’s securities that, upon the request of the Corporation or the underwriters managing any public offering of
the Corporation’s securities, the Participant will not sell or otherwise dispose of any shares without the prior written consent of the Corporation or such underwriters, as the case may be, for such period of time (not to exceed 180 days) after
the effective date of such registration requested by such managing underwriters and subject to all restrictions as the Corporation or the underwriters may specify. 

  
 8. Other Restrictions on Option and Shares. 
  

	 	(a)	As a condition to the issuance and delivery of shares subject to the Option, or the grant of any benefit pursuant to the terms of the Plan, the Corporation may, with the consent of
the Participant, require the Participant or other person to become a party to a stockholders’ agreement, buy-sell agreement, redemption agreement, repurchase agreement or other agreement between the Corporation and stockholders of the
Corporation or among stockholders of the Corporation or such other agreements imposing such restrictions as may be required by the Corporation. Notwithstanding the foregoing, the Participant hereby expressly acknowledges and
agrees that the Corporation shall require, prior to the issuance of any shares pursuant to this Agreement, that the Participant become a party to that certain Stockholders Agreement dated as of August 22, 2000, by and among Targacept, Inc. and the
stockholders thereof, as it may be amended from time to time, and the Participant hereby agrees to execute such agreement. 

  

	 	(b)	The Corporation may impose such restrictions on the Option and any shares issuable pursuant to the exercise of the Option as it may deem advisable, including without limitation
restrictions under the federal securities laws, the requirements of any stock exchange or similar organization and any blue sky or state securities laws applicable to such shares. Notwithstanding any other provision in the Plan or the Agreement to
the contrary, the Corporation shall not be obligated to issue, deliver or transfer shares of Common Stock, to make any other distribution of benefits, or to take any other action, unless such delivery, distribution or action is in compliance with
all applicable laws, rules and regulations (including but not limited to the requirements of the Securities Act). The Corporation will be under no obligation to register the shares of Common Stock with the SEC or to effect compliance with the
exemption, registration, qualification or listing requirements of any state securities laws, stock exchange or similar organization, and the Corporation will have no liability for any inability or failure to do so. The Corporation may cause a
restrictive legend to be placed on any certificate issued pursuant to the exercise of the Option in such form as may be prescribed from time to time by applicable laws and regulations or as may be advised by legal counsel. 

 

 9. Governing Law. Except as otherwise provided in the Plan or herein, this Agreement shall be
construed and enforced according to the laws of the State of Delaware, without regard to the conflict of laws provisions of any state. 
  
 10. Amendment and Termination; Waiver. Subject to the terms of the Plan, this Agreement may be modified or amended only by the written agreement of
the parties hereto. The waiver by the Corporation of a breach of any provision of the Agreement by the Participant shall not operate or be construed as a waiver of any subsequent breach by the Participant. 
  
 11. No Rights as a Stockholder. The Participant or his legal
representatives, legatees or distributees shall not be deemed to be the holder of any shares subject to the Option and shall not have any rights of a stockholder with respect to such shares unless and until certificates therefor have been issued and
delivered to him or them. 
  
 12. Withholding. The
Participant acknowledges that the Corporation shall require the Participant to pay the Corporation the amount of any federal, state, local or other tax or other amount required by any governmental authority to be withheld and paid over by the
Corporation to such authority for the account of the Participant, and the Participant agrees, as a condition to the grant of the Option, to satisfy such obligations. 
  
 13. Administration. The authority to construe and interpret this Agreement and the Plan, and to administer all
aspects of the Plan, shall be vested in the Administrator (as such term is defined in the Plan), and the Administrator shall have all powers with respect to this Agreement as are provided in the Plan. Any interpretation of the Agreement by the
Administrator and any decision made by it with respect to the Agreement is final and binding. 
  
 14. Notices. Except as may be otherwise provided by the Plan, any written notices provided for in this Agreement or the Plan shall be in writing and shall be deemed sufficiently given if either hand delivered
or if sent by fax or overnight courier, or by postage paid first class mail. Notices sent by mail shall be deemed received three business days after mailed but in no event later than the date of actual receipt. Notices shall be directed, if to the
Participant, at the Participant’s address indicated by the Corporation’s records, or if to the Corporation, at the Corporation’s principal office. 
  
 15. Severability. The provisions of this Agreement are severable and if any one or more provisions may be determined
to be illegal or otherwise unenforceable, in whole or in part, the remaining provisions shall nevertheless be binding and enforceable. 
  
 [SIGNATURE PAGE TO FOLLOW] 
  

 IN WITNESS WHEREOF, this Agreement has been executed in behalf of the Corporation and by the Participant
effective as of the day and year first above written. 
  

			
	TARGACEPT, INC.
		
	 By:
	 	 /s/ J. Donald deBethizy

	 	 	

	 	 	 Name: J. Donald deBethizy

	 	 	 Title: President

  

	
	 Attest:

	
	 /s/ August Borschke

	

	 Secretary

  
 [Corporate Seal] 
  

	
	PARTICIPANT
	
	 /s/ J. Donald deBethizy

	

	 J. Donald deBethizy

  

 2000 EQUITY INCENTIVE PLAN 
 OF 
 TARGACEPT, INC. 
  
 Stock Option Agreement 
 (Employees) 
  
 SCHEDULE A 
  
 Date
Option granted: September 15, 2000. 
 Date Option expires: September 15, 2010. 
 Number of shares subject to Option: 406,120 shares. 
 Option price (per share): $0.47. 
 Class of Option: Incentive. 
  

			
	 Date Installment
 First
Exercisable*

	  	Number of Shares
In Installment

	  
	 December 15, 2001
	  	33,844
	 March 15, 2002
	  	33,843
	 June 15, 2002
	  	33,843
	 September 15, 2002
	  	33,844
	 December 15,2002
	  	33,843
	 March 15, 2003
	  	33,843
	 June 15, 2003
	  	33,844
	 September 15, 2003
	  	33,843
	 December 15, 2003
	  	33,843
	 March 15, 2004
	  	33,844
	 June 15, 2004
	  	33,843
	 September 15, 2004
	  	33,843

  

	*	So long as the Employment Agreement dated August 22, 2000 between the Participant and the Corporation, as may be amended (the “Employment Agreement), remains effective, if the
Participant’s employment by the Corporation is terminated by (i) the Corporation (or its successor) without “Just Cause” or (ii) the Participant for “Good Reason” (all such terms as defined in the Employment Agreement), each
date set forth on this Schedule A shall be deemed accelerated by twelve (12) months (e.g., “June 15, 2002” shall become “June 15, 2001, “September 15, 2002” shall become “September 15, 2001,” etc.).

  

 EXHIBIT B 
  
 STOCK RESTRICTION AGREEMENT 
  

 STOCK RESTRICTION AGREEMENT 
  
 THIS STOCK RESTRICTION AGREEMENT (“Agreement”), is made and entered into as of the 22nd day of August, 2000, by
and between TARGACEPT, INC., a Delaware corporation (the “Company”), and Dr. J. Donald deBethizy (the “Stockholder”), an individual resident of North Carolina. 
  
 WITNESSETH: 
  
 WHEREAS, in order to induce the investors named in the Company’s Series B Convertible Preferred Stock Purchase Agreement of even date herewith to
consummate the purchase of up to 6,537,634 shares of the Company’s Series B Convertible Preferred Stock, $0.001 par value per share (“Series B Preferred”), the Stockholder has agreed to subject 135,373 shares of the Company’s
common stock, $0.001 par value (“Common Stock”), owned by the Stockholder as of the date hereof (the “Subject Shares”) to the terms and conditions hereof; and 
  
 WHEREAS, the continued services of the Stockholder as an employee of the Company are critical to the future success of the
Company, and the Stockholder has entered into an Employment Agreement with the Company of even date herewith (the “Employment Agreement”); 
  
 NOW, THEREFORE, in consideration of the premises, the mutual promises contained herein, the receipt and sufficiency of which are hereby acknowledged, the
parties agree as follows: 
  
 1. Capitalized Terms. All
capitalized terms used herein and not otherwise defined shall have the meaning given to them in the Employment Agreement. 
  
 2. Shares. The Subject Shares, together with all shares of capital stock of the Company hereafter acquired by the Stockholder in respect of the
Subject Shares through stock dividends, stock splits or other similar reorganization or recapitalization (together with the Subject Shares, the “Shares”), shall be subject to the provisions of this Agreement. 
  
 3. Vesting. All of the Shares shall be “vested” on August
22, 2001, and none of the Shares shall be “vested” until August 22, 2001. All Shares which are not “vested” shall be “unvested.” In no event shall the Stockholder sell, transfer, assign, pledge or otherwise encumber any
unvested Subject Shares. All unvested Shares shall be fully vested upon: (i) the death or “disability” (as defined in Section 6 of the Employment Agreement) of the Stockholder; (ii) the termination of the employment of the Stockholder by
(A) the Company (or its successor) other than for Just Cause, or (B) the Stockholder for Good Reason; or (iii) the occurrence of a “Significant Transaction” (as defined in the Company’s 2000 Equity Incentive Plan, as may be amended
from time to time). 
  

 4. Repurchase Option. 
  
 (a) Upon termination of the employment of the Stockholder by (i) the Company (or its successor) for Just Cause or (ii) the
Stockholder other than for Good Reason (in either case, a “Repurchase Event”), all of the unvested Shares shall be subject to the repurchase option set forth in Section 4(b) (the “Repurchase Shares”). 
  
 (b) For a period of sixty (60) days from the date of a Repurchase Event, the
Company shall have an option to repurchase all, but not less than all, of the Repurchase Shares. Such option must be exercised by the delivery of written notice thereof to the Stockholder (or to the Stockholder’s personal representative, if
applicable) prior to the expiration of the option. Upon the delivery of such notice of exercise, the Company shall be obligated to purchase from the Stockholder, and the Stockholder shall be obligated to sell to the Company, all of the Repurchase
Shares for the purchase price and upon the terms set forth herein. 
  
 5. Purchase Price. 
  
 (a) The purchase price for
all Repurchase Shares shall be the Stockholder’s original price per share paid in cash, if any. 
  
 (b) The Stockholder (or the Stockholder’s personal representative, if applicable) shall have no voice in the decisions of the Company pursuant to
Section 4, whether as a Stockholder, director, or officer of the Company; provided, however, that if necessary to secure valid corporate action, the Stockholder (or the Stockholder’s personal representative, if applicable) shall attend a
meeting of the Stockholders or directors and vote his shares or take such other action consistent with the request of a majority of the shares of Common Stock not held by the Stockholder. 
  
 6. Closing of Purchase and Payment of Purchase Price. 
  
 (a) Closing. The closing (the “Closing”) of a purchase hereunder shall take place at the principal office
of the Company, on a date selected by the Company which shall not be more than sixty (60) days following delivery by the Company of the notice referenced in Section 4 (the “Closing Date”). As a condition precedent to the Stockholder’s
obligation to close, the Company shall cause the Stockholder to be relieved of any and all personal liability with respect to guarantees made by the Stockholder of corporate obligations of the Company, or, if such release cannot be obtained, the
Company shall indemnify the Stockholder with respect to such obligations. 
  
 (b) Payment of Purchase Price. The purchase price for the Shares shall be payable to the Stockholder in cash or immediately available funds at the Closing. 
  

 7. Necessary Documents. If, under the terms of this Agreement, the Repurchase Shares are
purchased, the Stockholder, or the legal representative of the Stockholder, shall execute and deliver all necessary documents that may be reasonably required for accomplishing a complete transfer of such shares for the purpose of the repurchase
transaction. 
  
 8. Endorsement on Stock Certificates. Each
certificate representing the Shares of the Company now or hereafter held by the Stockholder shall be stamped with a legend in substantially the following form: 
  

“The shares of stock represented by this certificate are restricted under the terms of a Stock Restriction Agreement dated the 22nd day of August,
2000, a copy of which is on file at the office of the corporation.” 
  
 9. Notices. All notices, requests, demands, payments, and other communications hereunder shall be deemed to have been duly given if in writing and hand delivered or sent by certified mail to the appropriate
address indicated below or to such other address as may be given in a notice sent to all parties hereto: 
  

	 	(a)	If to the Company, to: 

  
 Targacept, Inc. 
 Bowman Gray Technical Center

 950 Reynolds Boulevard 
 Winston-Salem, North Carolina 27105 
  

	 	(b)	If to the Stockholder, to: 

  
 Dr. J. Donald deBethizy 
 2519 Woodbine Road

 Winston-Salem, NC 27104 
  
 10. Entire Agreement. This Agreement (together with the Employment Agreement) supersedes any and all other understandings and agreements, either
oral or in writing, between the parties hereto with respect to the subject matter hereof and constitutes the sole and only agreement between the parties with respect to said subject matter. Each party to this Agreement acknowledges that no
representations, inducements, promises or agreements, oral or otherwise, have been made by any party or by anyone acting on behalf of any party, which are not embodied herein (or in the Employment Agreement), and that no agreement, statement or
promise not contained in this Agreement (or the Employment Agreement) shall be valid or binding or of any force or effect. No change or modification of this Agreement shall be valid or binding upon the parties hereto unless such change or
modification is in writing and is signed by the parties hereto. 
  

 11. Severability. In the event that any one or more of the provisions contained in this Agreement
shall be held by a court of competent jurisdiction to be invalid, illegal or unenforceable in any respect for any reason, such invalidity, illegality or unenforceability shall not affect any other provisions hereof, and this Agreement shall be
construed as if that invalid, illegal or unenforceable provision had never been contained herein. 
  
 12. Parties Bound. The terms, promises, covenants and agreements contained in this Agreement shall apply to, be binding upon and inure to the
benefit of the parties hereto and their respective successors and assigns; provided, however, that this Agreement may not be assigned by the Stockholder without the prior written consent of the Company. 
  
 13. Governing Law. This Agreement shall be governed and construed in
accordance with the laws of the State of North Carolina, without regard to the principles of conflict of laws. 
  
 IN WITNESS WHEREOF, the parties hereto have hereunto set their hands and seals as of the day and year first above written, the corporate party acting
through its duly authorized officer. 
  

									
	 ATTEST:
	 	 	 	 Targacept, Inc.

				
	 /s/ August Borschke
	 	 	 	By:	 	 /s/ J. Donald deBethizy

	
	 	 	 	 	 	

	 August Borschke, Secretary
	 	 	 	 	 	 Name: J. Donald deBethizy

	 (Corporate Seal)
	 	 	 	 	 	 Title: President

  

									
			
	 	 	 	 	 /s/ J. Donald deBethizy

	 	 	 	 	 	

	 	 	 	 	 Dr. J. Donald deBethizy

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