Document:

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                                                                   EXHIBIT 10.12

                                   SCHEDULE B

                       ASPREVA PHARMACEUTICALS CORPORATION

                                                          As of January 23, 2004

Bruce Cousins
11 Liberty Bell Ct.
Belle Mead, NJ
U.S.A. 08502

Dear Mr. Cousins:

                         RE: CHANGE IN CONTROL AGREEMENT

            Aspreva Pharmaceuticals Corporation (the "CORPORATION") considers it
essential to the best interests of its members to foster the continuous
employment of its senior executive officers. In this regard, the Board of
Directors of the Corporation (the "BOARD") has determined that it is in the best
interests of the Corporation and its members that appropriate steps should be
taken to reinforce and encourage management's continued attention, dedication
and availability to the Corporation in the event of a Potential Change in
Control (as defined in Section 2), without being distracted by the uncertainties
which can arise from any possible changes in control of the Corporation.

            In order to induce you to agree to remain in the employ of the
Corporation, such agreement evidenced by the employment agreement entered into
as of the date of this Agreement between you and the Corporation (the
"EMPLOYMENT AGREEMENT") and in consideration of your agreement as set forth in
Section 3 below, the Corporation agrees that you shall receive and you agree to
accept the severance and other benefits set forth in this Agreement should your
employment with the Corporation be terminated subsequent to a Change in Control
(as defined in Section 2) in full satisfaction of any and all claims that now
exist or then may exist for remuneration, fees, salary, bonuses or severance
arising out of or in connection with your employment by the Corporation or the
termination of your employment:

1.    TERM OF AGREEMENT.

            This Agreement shall be in effect for a term commencing on the
Effective Date of the Employment Agreement (as therein defined) and ending on
the date of termination of the Employment Agreement.

2.    DEFINITIONS.

      (a)   "Affiliate" means a corporation that is an affiliate of the
            Corporation under the Securities Act (British Columbia), as amended
            from time to time.

      (b)   "Change in Control" of the Corporation shall be deemed to have
            occurred:

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                                     - 2 -

            (i)   if a merger, amalgamation, arrangement, consolidation,
                  reorganization or transfer takes place in which Equity
                  Securities of the Corporation possessing more than 50% of the
                  total combined voting power of the Corporation's outstanding
                  Equity Securities are acquired by a person or persons
                  different from the persons holding those Equity Securities
                  immediately prior to such transaction, and the composition of
                  the Board following such transaction is such that the
                  directors of the Corporation prior to the transaction
                  constitute less than 50% of the Board membership following the
                  transaction, except that no Change in Control will be deemed
                  to occur if such merger, amalgamation, arrangement,
                  consolidation, reorganization or transfer is with any
                  subsidiary or subsidiaries of the Corporation;

            (ii)  if any person, or any combination of persons (different from
                  those person(s) holding Equity Securities prior to the date
                  hereof) acting jointly or in concert by virtue of an
                  agreement, arrangement, commitment or understanding shall
                  acquire or hold, directly or indirectly, 50% or more of the
                  voting rights attached to all outstanding Equity Securities;
                  or

            (iii) if any person, or any combination of persons (different from
                  those person(s) holding Equity Securities prior to the date
                  hereof) acting jointly or in concert by virtue of an
                  agreement, arrangement, commitment or understanding shall
                  acquire or hold, directly or indirectly, the right to appoint
                  a majority of the directors of the Corporation; or

            (iv)  if the Corporation sells, transfers or otherwise disposes of
                  all or substantially all of its assets, except that no Change
                  of Control will be deemed to occur if such sale or disposition
                  is made to a subsidiary or subsidiaries of the Corporation.

            provided however, that a Change in Control shall not be deemed to
            have occurred if such Change in Control results solely from the
            issuance of Equity Securities in connection with a bona fide
            financing or series of financings by the Corporation.

      (c)   "Base Salary" shall mean the annual base salary, as referred to in
            Section 3 (Base Salary), and as adjusted from time to time in
            accordance with Section 4 (Annual Review), of the Employment
            Agreement.

      (d)   "Bonus" shall mean the bonus referred to in Section 5 (Performance
            Bonus) of the Employment Agreement.

      (e)   "Cause" shall have the meaning set out in Section 17 (Termination by
            the Corporation for Cause) of the Employment Agreement.

      (f)   "Date of Termination" shall mean, if your employment is terminated,
            the date specified in the Notice of Termination.

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                                     - 3 -

      (g)   "Equity Security" in respect of a security of the Corporation, shall
            have the meaning ascribed thereto in Part 11 of the Securities Act
            (British Columbia), as it existed on the date of this Agreement, and
            also means any security carrying the right to convert such security
            into, exchange such security for, or entitling the holder to
            subscribe for, any equity security, or into or for any such
            convertible or exchangeable security or security carrying a
            subscription right.

      (h)   "Good Reason" shall mean the occurrence of one or more of the
            following events, without your express written consent, within 12
            months of Change in Control:

            (i)   a material change in your status, position, authority or
                  responsibilities that does not represent a promotion from or
                  represents an adverse change from your status, position,
                  authority or responsibilities in effect immediately prior to
                  the Change in Control;

            (ii)  a material reduction by the Corporation, in the aggregate, in
                  your Base Salary, or incentive, retirement, health benefits,
                  bonus or other compensation plans provided to you immediately
                  prior to the Change in Control, unless an equitable
                  arrangement has been made with respect to such benefits in
                  connection with a Change in Control;

            (iii) a failure by the Corporation to continue in effect any other
                  compensation plan in which you participated immediately prior
                  to the Change in Control (except for reasons of
                  non-insurability), including but not limited to, incentive,
                  retirement and health benefits, unless an equitable
                  arrangement has been made with respect to such benefits in
                  connection with a Change in Control;

            (iv)  any request by the Corporation or any affiliate of the
                  Corporation that you participate in an unlawful act; or

            (v)   any purported termination of your employment by the
                  Corporation after a Change in Control which is not effected
                  pursuant to a Notice of Termination satisfying the
                  requirements of clause (i) below and for the purposes of this
                  Agreement, no such purported termination shall be effective.

      (i)   "Notice of Termination" shall mean a notice, in writing,
            communicated to the other party in accordance with Section 6 below,
            which shall indicate the specific termination provision in this
            Agreement relied upon and shall set forth in reasonable detail the
            facts and circumstances claimed to provide a basis for termination
            of your employment under the provision so indicated.

      (j)   "Potential Change in Control" of the Corporation shall be deemed to
            have occurred if:

            (i)   the Corporation enters into an agreement, the consummation of
                  which would result in the occurrence of a Change in Control;

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            (ii)  any person (including the Corporation) publicly announces an
                  intention to take or to consider taking actions which if
                  consummated would constitute a Change in Control; or

            (iii) the Board adopts a resolution to the effect that, for the
                  purposes of this Agreement, a Potential Change in Control of
                  the Corporation has occurred.

3.    POTENTIAL CHANGE IN CONTROL.

            You agree that, in the event of a Potential Change in Control of the
Corporation occurring after the Effective Date, and until 12 months after a
Change in Control, subject to your right to terminate your employment by issuing
and delivering a Notice of Termination for Good Reason, you will continue to
diligently carry out your duties and obligations, on the terms set out in the
Employment Agreement.

4.    COMPENSATION UPON TERMINATION FOLLOWING CHANGE IN CONTROL.

            Subject to compliance by you with Section 3, upon your employment
terminating pursuant to a Notice of Termination within 12 months after a Change
in Control, the Corporation agrees that you shall receive and you agree to
accept, the following payments in full satisfaction of any and all claims you
may have or then may have against the Corporation, for remuneration, fees,
salary, benefits, bonuses or severance, arising out of or in connection with
your employment by the Corporation or the termination of your employment:

      (a)   If your employment shall be terminated by the Corporation for Cause
            or by you other than for Good Reason, the terms of the Employment
            Agreement shall govern and the Corporation shall have no further
            obligations to you under this Agreement.

      (b)   If your employment by the Corporation shall be terminated by you for
            Good Reason or by the Corporation other than for Cause, then you
            shall be entitled to the payments and benefits provided below:

            (i)   subject to the withholding of all applicable statutory
                  deductions, the Corporation shall pay you a lump sum equal to
                  12 months' Base Salary, as referred to in Section 3 (Base
                  Salary) and as adjusted from time to time in accordance with
                  Section 4 (Annual Review) of the Employment Agreement, plus
                  other sums owed for arrears of salary, vacation pay and, if
                  awarded, Bonus;

            (ii)  to the extent permitted by law and subject to the terms and
                  conditions of any benefit plans in effect from time to time,
                  the Corporation shall maintain the benefits and payments set
                  out in Section 6 (Benefits) of the Employment Agreement during
                  the 12 month period;

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            (iii) the Corporation shall arrange for you to be provided with such
                  outplacement career counselling services as are reasonable and
                  appropriate, to assist you in seeking new executive level
                  employment; and

            (iv)  all incentive stock options and trust shares granted to you by
                  the Corporation under any stock option and/or trust share
                  agreement that is entered into between you and the Corporation
                  and is outstanding at the time of termination of your
                  employment, which incentive stock options and or trust shares
                  have not yet vested, shall immediately vest upon the
                  termination of your employment and shall be fully exercisable
                  by you in accordance with the terms of the agreement or
                  agreements under which such options were granted.

You shall not be required to mitigate the amount of any payment provided for in
this Section 4 by seeking other employment or otherwise, nor will any sums
actually received be deducted.

5.    BINDING AGREEMENT.

            This Agreement shall enure to the benefit of and be enforceable by
your personal or legal representatives, executors, administrators, successors,
heirs, distributees, devisees and legatees. If you die while any amount would
still be payable to you under this Agreement if you had continued to live, that
amount shall be paid in accordance with the terms of this Agreement to your
devisee, legatee or other designee or, if there is no such designee, to your
estate.

6.    NOTICES.

            All notices and other communications that are required or permitted
by this Agreement must be in writing and shall be hand delivered or sent by
express delivery service or certified or registered mail, postage prepaid, or by
facsimile transmission (with written confirmation copy by registered mail) to
the parties at the addresses indicated below.

            IF TO ASPREVA:

            Aspreva Pharmaceuticals Corporation
            Farris, Vaughan, Wills & Murphy
            26th Floor, 700 West Georgia Street
            Vancouver, BC V7Y 1B3

            Attn: R. Hector MacKay-Dunn

            IF TO MR. BRUCE COUSINS:

            Bruce Cousins
            11 Liberty Bell Ct.
            Belle Mead, NJ
            U.S.A. 08502

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                                     - 6 -

Any such notice shall be deemed to have been received on the earlier of the date
actually received or the date five (5) days after the same was posted or sent.
Either party may change its address or its facsimile number by giving the other
party written notice, delivered in accordance with this Section.

7.    MODIFICATION: AMENDMENTS: ENTIRE AGREEMENT.

            This Agreement may not be modified, waived or discharged unless such
waiver, modification or discharge is agreed to in writing and signed by you and
such officer as may be specifically designated by the Board. No waiver by either
party at any time of any breach by the other party of, or compliance with, any
condition or provision of this Agreement to be performed by such other party
will be deemed a waiver of similar or dissimilar provisions or conditions at the
same or at any prior or subsequent time. Except as set forth in your Employment
Agreement, no agreements or representations, oral or otherwise, express or
implied, with respect to the subject matter hereof have been made by either
party which are not expressly set forth in this Agreement.

8.    GOVERNING LAW.

            This Agreement shall be governed by and interpreted in accordance
with the laws of the Province of British Columbia and applicable laws of Canada
and the parties hereto attorn to the exclusive jurisdiction of the provincial
and federal courts of such province.

9.    VALIDITY.

            The invalidity or unenforceability of any provision of this
Agreement shall not affect the validity or enforceability of any other provision
of this Agreement, which shall remain in full force and effect.

10.   NO EMPLOYMENT OR SERVICE CONTRACT

            Nothing in this Agreement shall confer upon you any right to
continue in the employment of the Corporation for any period of specific
duration or interfere with or otherwise restrict in any way the rights of the
Corporation or you, which rights are hereby expressly reserved by each, to
terminate your employment at any time for any reason whatsoever, with or without
cause.

            If the foregoing sets forth our agreement on this matter, kindly
sign and return to the Corporation a copy of this letter.

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                                     Yours truly,

                                     ASPREVA PHARMACEUTICALS CORPORATION

                                     By:    /s/ RICHARD M. GLICKMAN
                                            ------------------------------
                                            Authorized Signatory

Accepted and agreed to by Mr. Bruce Cousins as of the 6th day of February, 2004

/s/ BRUCE COUSINS
-----------------
MR. BRUCE COUSINS<PAGE>
                                                                   EXHIBIT 10.13

                         TRUST SHARE TRANSFER AGREEMENT

BETWEEN:

            RICHARD M. GLICKMAN, an individual resident in the Province of
            British Columbia

            (the "TRUSTEE")

AND:

            BRUCE G. COUSINS, an individual resident in the Province of British
            Columbia

            (the "TRANSFEREE")

WHEREAS:

A.    The Trustee is the trustee of the 2002 Aspreva Incentive Stock Purchase
      Plan Trust Agreement (the "TRUST AGREEMENT");

B.    The Trustee desires to transfer to the Transferee, and the Transferee
      desires to receive, 20,000 common shares (the "TRUST SHARES") in the
      capital of Aspreva Pharmaceuticals Corporation (the "COMPANY"); and

C.    The board of directors of the Company has approved the transfer of the
      Trust Shares from the Trustee to the Transferee.

NOW THEREFORE THIS AGREEMENT WITNESSES that in consideration of the premises,
the mutual covenants and agreements set forth in this Agreement and other good
and valuable consideration (the receipt and sufficiency of which is hereby
acknowledged by each of the parties), the parties hereby agree as follows:

1.    Transfer. The Trustee hereby agrees that, as soon as reasonably
      practicable following the execution of this Agreement, the Trustee will
      distribute to the Transferee under the Trust Agreement the Trust Shares
      and will cause to be delivered to the Transferee a share certificate (the
      "TRUST SHARE CERTIFICATE") registered in the Transferee's name
      representing the Trust Shares.

2.    Agreement to Be Bound. The Transferee agrees that, as a condition to being
      entitled to receive the Trust Shares and the Trust Share Certificate, the
      Transferee will execute and deliver to the Company, in a form satisfactory
      to the Company's solicitors, an agreement to be bound (the "AGREEMENT TO
      BE BOUND") to the amended and restated shareholders' agreement dated March
      5, 2004, as amended, between the Company and its shareholders.

3.    Return of Trust Shares. The Transferee agrees that, as an additional
      condition to being entitled to receive the Trust Shares and the Trust
      Share Certificate, the Transferee will, if the Transferee's executive
      employment agreement between the Transferee and the
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                                     - 2 -

      Company (the "EMPLOYMENT AGREEMENT") dated January 23, 2004 is terminated
      in accordance with its terms, immediately transfer to the Trustee, or as
      the Trustee may direct, for no consideration, all right, title and
      interest in and to the following Trust Shares, if any, and will cause a
      certificate representing such Trust Shares to be issued to the Trustee, or
      as the Trustee may direct, unless there has been a "CHANGE IN CONTROL" of
      the Company (as defined in the change of control agreement between the
      Company and the Transferee dated January 23, 2004 and attached to the
      Employment Agreement as Schedule B) during the term of the Employment
      Agreement:

      <Table>
      <Caption>

      TERMINATION DATE               NUMBER OF TRUST SHARES TO BE TRANSFERRED
      ----------------               ----------------------------------------
      <S>                                          <C>
      Before April 15, 2004                        19,444
      Before May 15, 2004                          18,888
      Before June 15, 2004                         18,332
      Before July 15, 2004                         17,776
      Before August 15, 2004                       17,220
      Before September 15, 2004                    16,664
      Before October 15, 2004                      16,108
      Before November 15, 2004                     15,552
      Before December 15, 2004                     14,996
      Before January 15, 2005                      14,440
      Before February 15, 2005                     13,884
      Before March 15, 2005                        13,328
      Before April 15, 2005                        12,772
      Before May 15, 2005                          12,216
      Before June 15, 2005                         11,660
      Before July 15, 2005                         11,104
      Before August 15, 2005                       10,548
      Before September 15, 2005                     9,992
      Before October 15, 2005                       9,436
      Before November 15, 2005                      8,880
      Before December 15, 2005                      8,324
      Before January 15, 2006                       7,768
      Before February 15, 2006                      7,212
      Before March 15, 2006                         6,656
      Before April 15, 2006                         6,100
      Before May 15, 2006                           5,544
      Before June 15, 2006                          4,988
      Before July 15, 2006                          4,432
      Before August 15, 2006                        3,876
      Before September 15, 2006                     3,320
      Before October 15, 2006                       2,764
      Before November 15, 2006                      2,208
      Before December 15, 2006                      1,652
      Before January 15, 2007                       1,096
      Before February 15, 2007                        540
      On or before March 15, 2007                     NIL

      </Table>

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                                     - 3 -

4.    Governing Law. This Agreement shall be governed by and interpreted in
      accordance with the laws of the Province of British Columbia and
      applicable laws of Canada and the parties hereto attorn to the exclusive
      jurisdiction of the provincial and federal courts of British Columbia.

5.    Entire Agreement. This Agreement constitutes the entire agreement between
      the parties with respect to the subject matter hereof, and may only be
      varied by further written agreement of the Trustee and the Transferee.
      This Agreement supersedes any previous communications, understandings and
      agreements between the Trustee and the Transferee.

6.    Further Assurances. The parties will execute and deliver to each other
      such further instruments and assurances and do such further acts as may be
      required to give effect to this Agreement.

7.    Headings. Marginal headings as used in this Agreement are for the
      convenience of reference only and do not form a part of this Agreement and
      are not to be used in the interpretation hereof.

8.    Wording. Whenever the singular or masculine or neuter is used throughout
      this Agreement the same shall be construed as meaning the plural or
      feminine or body corporate when the context or the parties hereto may
      require.

                 [THE REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK]
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9.    Notice. All notices and other communications that are required or
      permitted by this Agreement must be in writing and shall be hand delivered
      or sent by express delivery service or certified or registered mail,
      postage prepaid, to the parties at the addresses indicated below.

           IF TO THE TRUSTEE:

           Richard M. Glickman
           2377 Tyron Road
           Sidney, BC  V8L 5H8

           IF TO THE TRANSFEREE:

           Bruce G. Cousins
           4505 Emily Carr Drive
           Victoria, BC  V8X 2N5

      Any such notice shall be deemed to have been received on the earlier of
      the date actually received or the date five (5) days after the same was
      posted or sent. Either party may change its address by giving the other
      party written notice, delivered in accordance with this Article 9.

10.   Counterparts. This Agreement may be executed in any number of
      counterparts, each of which so executed shall be deemed to be an original,
      and such counterparts will together constitute but one Agreement.

      DATED effective December 8, 2004.

/s/ RICHARD M. GLICKMAN                    /s/ BRUCE G. COUSINS
-----------------------------------        -----------------------------------
RICHARD M. GLICKMAN, Trustee               BRUCE G. COUSINS
of the 2002 Aspreva Incentive Stock
Purchase Plan Trust Agreement

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