Document:

EX-10.10

 Exhibit 10.10 
  

 

 

 The licensee(s) identified on the signature page of this agreement (the “Licensee” or
“Client”) and CIC hereby agree to the following (the “Agreement” or “Service Agreement”). 
 Please note that
“Client”, “you” and “your” refer to the aforementioned Licensee, and “CIC”, “we” and “our” refer to CIC Innovation Communities, LLC, as duly authorized agent for the Licensors identified on
Exhibit A, and/or, to the extent applicable from time to time, any affiliates providing services to the Licensors identified on Exhibit A. 
 1.
License: On behalf of the Licensors identified in Exhibit A, CIC hereby grants you, and you hereby accept from CIC, a license and privilege to operate an office and use the facilities designated by CIC (and as set forth in our monthly invoice to
you) at one or more of the premises indicated in Exhibit A (individually and collectively the “Premises” or “CIC Premises”). This license does not convey title to any land or buildings and does not create a possessory interest or
tenancy of any kind. 
 Either party may terminate this Agreement and license for any reason or no reason with 30 days’ written
notice (the “Termination Notice”). 
 2. Space and Services: We will provide you with one or more workspaces, use of a variety of common
facilities, and a range of related office services detailed by location in Exhibit A. Prior to commencing use of a CIC workspace, it is your responsibility to ensure that you have obtained and reviewed an acceptable quote and you acknowledge the
listed spaces and services have been requested and agreed-to. 
 With our consent, you may add additional workspaces and services under
this Agreement at any time, in any CIC Premises. With respect to each CIC Premises in which you operate or use facilities, you agree that the applicable location-specific provisions for those CIC Premises listed in Exhibit A are hereby incorporated
into this Agreement. These provisions are individually and collectively referred to herein as “Exhibit A”. 
 CIC’s
facilities are open to you 24x7, and you may conduct business in these at any time. The building provides HVAC services during normal business hours. For details by location, see Exhibit A. Use of the Premises for large, private events is possible
by prior arrangement. 
         You acknowledge that even in the best-managed office environments, systems,
services, and security failures will occur. We will make our best efforts to provide quality services and otherwise maintain a quality environment, but you acknowledge that we are not responsible for financial or other losses as a consequence of the
receipt of services from us, or lack or insufficiency thereof, regardless of the cause. 
 You agree that the services or actions that may
be performed by CIC under this Agreement may also be performed by affiliates of CIC.

 3. Moving Out: One of the benefits of our offering is to give the flexibility to be able to move
elsewhere on short notice if their needs change. CIC requests that you provide as much informal notice as possible of any planned decrease in your use of our services. Giving us an idea of your future plans will not prejudice your access to current
services, and may allow us to introduce you to alternative options. 
 Over and above any informal conversations you may have with us, you
agree to provide CIC at least 30 days’ advance formal definitive written notice of termination of this Agreement (the “Termination Notice”) as well as of any material reduction of your use of space or services under this agreement.
This means 30 days’ Notice is required if you plan to leave, but also if you plan to drop a part of your space at any of CIC’s facilities. Please keep in mind that once you give us formal Notice, CIC will release that space for reservation
by others following the date you told us you will no longer require it, and it may not be possible for you to later reverse your decision. 

Sometimes clients need to vacate their space in less than 30 days from the time they provide us Notice. If this happens, you will still be
responsible for full payment for your fees through the date that is 30 days after Notice is given, regardless of whether we reuse your space for others soon thereafter. 

Any time CIC reasonably believes a Client has vacated, abandoned a particular space, has left it and does not plan to return to work there,
and/or does not plan to continue to pay its fees to CIC, we may deem your space to be vacant, we may pack up and remove your stuff, and we may redeploy the space to others’ use. If you had not given formal Termination Notice, we will deem that
your Termination Notice was given on the date that we make the above determination. We will do our best to inform the responsible parties at Client of this action. 

4. Use of Office: You may use the office for general office purposes and for any other purposes set forth by location in Exhibit A and for no other
purpose without prior written permission from CIC. Client may install typical office equipment of the type and quantity typically in use in modern offices. Client shall not install other equipment without the written consent of CIC. 

        Most services provided by CIC are provided on an ‘unmetered’ basis. This ‘unmetered’ basis
is premised on a good-faith understanding between CIC and the Client that this privilege will not be abused. Employing CIC’s services well beyond normal office use, defined as the norm amongst other clients, without prior discussion, after
having received Notice that CIC is concerned about this level of use, and having been given a reasonable opportunity to cure it, may be considered a breach of this Agreement. We find such over-use at CIC’s facilities is rare. An example would
be printing high volumes of material on the color printer. We would say this is a job for a printing company. Most special needs can be accommodated by prior arrangement.

 

  

							
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 CIC is particularly sensitive to conference room use in this regard. We define “normal
use” as frequent short meetings throughout the day, long meetings occasionally, and multi-day long meetings very occasionally. All-day meetings should be no more frequent than once per quarter, on average. You may not use the conference rooms
for private phone calls during business hours (9 am – 5 pm). More liberal usage during off-hours and weekends is fine. Some larger client spaces have dedicated conference spaces, to which these guidelines do not apply. If you expect to need to
go beyond these guidelines, please discuss with us before moving in. 
 5. Mail Service: If mail or packages arrive for you at CIC’s Premises,
you give CIC permission to receive, sign for, and sort your mail and packages on your behalf. We perform this work during regular business hours. We will place your mail in a folder designated for your company in our mail room, and will shelve
packages in a shared package retrieval area. Other clients of CIC have access to these areas. In certain circumstances we may choose to deliver items to your work area, but this is not a regular service. We endeavor to handle your mail and packages
with care, and it is not expected that items will be lost, damaged, delayed, mis-delivered, or stolen. This said, given the shared nature of our facilities, we cannot ensure that these things won’t happen. Accordingly, you agree to accept the
risk that these things could happen, and that CIC and its affiliated Licensors shall not be liable for the same. 
 If you receive mail at
the Premises and later leave, you are responsible for recording your change-of-address with the USPS effective on the date of your departure. Note that CIC is not legally able to do this for you. CIC will not itself manually forward mail to your new
address unless you make special arrangements for this. If mail forwarding is not arranged directly with CIC, mail and packages will be either forwarded back through the postal system (if your change-of-address is on file with the post office) or
returned to sender after a one-month grace period after your official move-out date. 
 6. Payment: Client will timely pay all fees invoiced to it
by, or otherwise due and payable to, CIC. All fees payable under this Agreement shall be due and payable in advance in US Dollars to “CIC” on the first day of each month that this Agreement is in effect. Each monthly invoice bills in
advance for the month ahead, and may also include charges from previous months that have not yet been invoiced. Incidental charges payable under this agreement (e.g. international phone charges) are included in the next regular monthly invoice after
they are determined, and shall be due and payable as part of that invoice. All charges appearing on the monthly invoice shall be considered final and agreed to if not questioned by Notice within 90 days of the invoice date. Client shall be obligated
to pay CIC interest at the rate of ten percent (10%) per annum on all sums Client is obligated to pay under the terms of this Agreement from the date fifteen (15) days after said sums become due and remain unpaid until the date such sums
are paid in full. In addition, Client shall pay reasonable attorney’s and/or arbitrator’s fees and other costs incurred by CIC in conjunction with collecting any late payment, all of which are to be paid by Client within five (5) days
of receipt of CIC’s invoice therefore. Notwithstanding the foregoing, before assessing interest charges the first time in any six (6) month period, CIC shall provide the Client Notice of the delinquency, and shall waive such interest
payment if the Client pays such delinquent amount within five (5) days thereafter.

 The standard method of payment that CIC accepts is automatic bank debit. An automatic debit
authorization form is attached hereto in Exhibit B. For any client for which automatic debit is impractical, you have the option of paying by check or wire transfer, but in conjunction with that you agree to increase your deposit on hand with CIC by
one month beyond that required in Section 8 below. Any client electing to pay by wire transfer also agrees to pay wire transfer bank fees as part of their monthly invoice, the amount of which may vary from time to time as determined by
CIC’s bank. CIC acknowledges that Client may cancel the automatic debit authorization at will, however such cancellation without payment in advance of the additional one month deposit may be deemed by CIC a 30-day Termination Notice under this
Agreement. 
 7. Access to Client spaces: You acknowledge that CIC’s active management of the office space and CIC’s provision of a variety
of office services including, where applicable, phones, internet connections, and so forth necessitates that CIC be able to access your offices in the same manner that your own internal office managers and technology support staff would, without
advance notice, in order to provide said services, view the condition of the office, make alterations and repairs and so forth. We will make reasonable efforts to ensure that such visits do not disrupt your operations. 

8. Deposit: Upon execution of this Agreement, you shall pay a deposit equal to one month’s ongoing monthly fees for the performance of all the
provisions of this Agreement (the “Deposit”). In the event that the amount of your ongoing monthly fees has increased or decreased, the dollar amount of the required Deposit will adjust monthly to reflect the new ongoing monthly fees (for
example: if you double the amount of space you have and thus your monthly fees double, the amount of your required deposit will double as well, to keep in step with your fees). 

CIC may apply your Deposit to any charges or other payments due from you or to any other amount CIC may be required to expend on your
behalf. If the Deposit that CIC has on hand from you falls below the required level for any reason, upon being given Notice of this situation, you shall reimburse CIC for any amount required such that the Deposit on hand will not be less than the
full required amount under this Agreement. 
 The required Deposit amount shall be increased by an additional one (1) month’s
fees if you are late in payment on two (2) separate occasions, where Notice of your lateness is provided after the first occasion. 

If you are not in default or breach of this Agreement, the unapplied balance of the Deposit shall be returned to you without interest within
30 days’ after your departure. 
 9. Liability for Damages: You acknowledge liability for any damage to equipment, furnishings, and any other
property of CIC, the Licensors, their Landlords, or their other clients or tenants caused by Client, its employees, guests, or affiliated parties, excluding damage due to normal wear and tear. Client agrees to pay the cost to repair or replace (at
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cost) the damaged property, at the discretion of CIC. Such charges shall be treated as incidental charges as specified in Paragraph 6. 

10. Acceptable use rules and regulations: You acknowledge that no trade or occupation shall be conducted in the office or use made thereof which will
be unlawful, improper or offensive, or contrary to any law or any municipal by-law or ordinance in force in the location where the Premises are located. CIC explicitly prohibits the conduct of business directly related to pornography or gambling.

 You agree that you will not cause or permit to be caused disturbances, create odors or situations any of which may be offensive to
other clients or that would interfere with the normal operations of CIC and its other clients. You also agree with CIC that you will not use tobacco products, including electronic cigarettes or smoking devices, while in CIC’s buildings. While
at CIC’s facility, you agree not to intentionally display or print pornography, or to permit the same. You agree not to send unsolicited commercial email (spam) using CIC’s network, and to cooperate fully when requested by CIC to remove
viruses, worms, Trojans, bots and other malware from its computer systems. 
 To minimize interference with the common wireless data and
voice network(s) CIC provides for the use of all clients, you agree that you will not set up an independent wireless network at CIC’s facility without prior consultation and written approval from CIC’s technology staff. 

You may not offer workplace-related services that compete with those offered by CIC. 

CIC does not permit its facilities to be used as a substitute for sleeping accommodations. Actively choosing to sleep at CIC’s facility
for the night is not consistent with the function of our facility, and we are not equipped to support it. 
 Clients are welcome to state
that they are located at CIC’s facility and are a client of CIC. Client agrees not to describe CIC as a business partner (or similar) without written permission. 

It is understood and agreed that you shall comply with any rules and regulations issued by CIC, Licensor, or their Landlords from time to
time from and after the date on which you are made aware of such rules and regulations. 
 11. Non-discrimination: CIC does not discriminate on the
basis of race, gender, religion, age, ethnic or national origin, disability, sexual orientation or sexual identity. 
 12. Acceptable Ethics, Integrity
and Conduct: CIC reserves the right to make determinations in its sole discretion regarding acceptable standards of ethics, integrity and conduct of those who wish to enter CIC’s Premises. Based on information it has, CIC may place an
access restriction on particular individuals, which could include Client employees, potential recruits, or other Client parties. If this happens, these individuals will not be permitted to come on the premises of CIC or its affiliates, including for
example the Venture Café Foundation Inc. and locations it manages. Application may be made to CIC for special arrangements for access where there is a compelling reason. You acknowledge that CIC will generally not communicate to you the
reason for such restrictions. 

 13. Addressing Conflict and Inappropriate Behavior: Client understands that from time to time conflicts
can occur between individuals in any shared environment such as CIC’s, and that employees and other invitees of clients can be accused of inappropriate behavior in ways that require a response from CIC management in order for CIC to ensure a
safe and supportive working environment for all. Such situations may or may not be contrary to law, and they may or may not be readily provable. If such a situation occurs, Client agrees that CIC may use its best judgment with regard to how to
resolve or eliminate the issue, with the goal of rapidly and cost-effectively ensuring an outcome that is acceptable to CIC and the community at large. Depending on the nature and severity of the allegation CIC receives, the information CIC has, the
extent of readily available proof of such information or allegations, and how likely CIC believes the situation is to reoccur, CIC may elect to privately and confidentially seek to resolve the issue directly with Client’s employee or invitee
(without notifying Client’s management) or may elect to directly involve Client’s management. In the event that Client’s management is not notified, the intent is generally to protect the privacy of the accused individual where CIC
believes the situation calls for this, in CIC’s judgment, and can be resolved amicably and permanently. In many cases it is possible to achieve resolutions without requiring an investigation. Such resolutions can include the accused party
simply acknowledging that they have “heard” the concern, and agreeing to take care in the future that such concerns do not arise again. If circumstances make an extensive investigation unavoidable, or such is required by a court or law
enforcement, Client will be responsible for the cost of investigation of matters relating to its employees or invitees’ alleged inappropriate behavior. If in CIC’s judgment the presence of an individual would represent an ongoing hindrance
to CIC’s ability to ensure a safe and supportive environment, CIC will let the Client know that Client will no longer grant access to CIC premises for that individual. Client has a duty to CIC and the community at large to take care in the
selection of its employees and choice of its invitees and to notify CIC of any situations or circumstances that it considers dangerous or which it believes could pose a threat to the safety or security of CIC or individuals at CIC. Client
acknowledges that it is responsible for the actions of individuals it permits to enter the Premises. Client agrees that CIC is not responsible for the economic consequences to Client or the accused individual as a result of actions taken by CIC in
good faith to protect the community and that any losses related to Client parties that CIC sustains are the Client’s responsibility under the indemnification section of this agreement (Section 16). 

14. Insurance: With respect to the spaces it makes use of from time to time within the Premises, Client agrees to maintain at its own cost during the
term hereof insurance coverage for Comprehensive General Liability Insurance (CGL) in an amount not less than $1,000,000 for general property damage and personal injury (including, without limitation, bodily injury, sickness, disease, and death) and
$2,000,000 in aggregate liability coverage, as well as a policy of fire, vandalism, malicious mischief, extended coverage and

 

  

							
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so-called “all risk” coverage insurance in an amount equal to one hundred percent (100%) of the replacement cost insuring all of Client’s furniture, equipment, fixtures and
property of every kind, nature and description which may be in or upon the Premises. Exhibit A of this Agreement lists the entities, such as Landlords, building property managers, and CIC affiliates that play a role supporting you in each of the
locations where you have offices with CIC. You agree directly and on behalf of your insurer that each of those entities listed in Exhibit A associated with the locations that you use or operate an office in shall be additional insureds on a primary
and non-contributory basis under your general liability insurance (“Additional Insureds”). Whenever you take on additional space at a CIC location, you agree that the newest version of Exhibit A, which can be found at
www.cic.us/exhibita, shall be considered the relevant Exhibit A for the purposes of this Agreement. Some CIC locations may have additional insurance requirements as outlined in Exhibit A, and Client agrees to maintain coverage for all such
requirements of each location Client uses or operates in. 
 To demonstrate that the above is agreed and acknowledged, such CGL must include precisely the
following endorsement: “CIC Innovation Communities LLC and those entities listed in Exhibit A of the Service Agreement between the named insured and CIC Innovation Communities LLC, as it may be amended from time to time, are included as
Additional Insureds on a primary and non-contributory basis under this Commercial General Liability Insurance.” Prior to the date Client takes possession of its assigned office, Client shall provide CIC with all endorsements and an ACORD
25-S or ACORD-28 certificate which must spell out the above endorsement. A sample ACORD 25-S certificate is included for your convenience. 
 To the extent
required by law, the Client also shall carry Worker’s Compensation Insurance. The insurance required under this section must be placed with insurers authorized to do business where the Premises are located, with a rating of not less than
“A-VIII” in the current Best’s Insurance Reports. All policies required under this section shall be written as primary policies and not contributing to or in excess of any coverage CIC or the Licensors may otherwise maintain. All
insurance herein required shall be deemed an obligation of Client, not a discharge or limitation of Client’s obligation to indemnify CIC or the Licensors. If CIC provides the name of a particular broker or insurer to the Client, Client agrees
that Client is itself nevertheless the sole party responsible for ensuring that such coverage meets these requirements. For purposes of insurance, the insurer may wish to review Exhibit A for more building specific information. 

15. Fire and Fire Insurance: The Client shall not permit any use of fire in its offices (candles, matches, etc.) for any reason. It will further not
permit any use of the office which will make voidable any insurance on the property of which the office is a part, or on the contents of said property or which shall be contrary to any applicable law or regulation as such may be imposed over time.

 16. Indemnification and Liability: To the greatest extent permitted by law, except for harm caused by
gross negligence or willful misconduct of CIC or the Licensors, Client hereby indemnifies and holds harmless CIC, the Licensors, affiliates of CIC or Licensors, and their respective officers, employees, agents, contractors, Landlords, Related
Parties, other clients and property manager from any claims, liabilities, losses or damages incurred by Client or such persons and entities (including all costs and expenses of defense of any action or proceeding) arising out of, directly or
indirectly, any claim against, incident to or any injury to or death of the Client, its employees, its assigns, its agents or invitees of any of them or any damage to or loss of property of such persons or entities. Client shall maintain adequate
insurance for the foregoing and present evidence of same to CIC upon request. 
 If any court should find any person or entity indemnified
hereunder liable for any loss or damage of any kind for any reason related to Client, employees, guests and affiliated parties, Client agrees that, to the greatest extent permitted by law, the limit of such person’s or entity’s liability
shall be the amount that Client has paid CIC under this Agreement. 
 17. Waiver of Subrogation: Client hereby (i) waives on behalf of itself
and its insurer(s) (none of which shall ever be assigned any such claim or be entitled thereto due to subrogation or otherwise) any and all rights of recovery, claim, action, or cause of action against Landlord, Sublandlord(s), CIC, the Licensors,
any Additional Insureds as defined on Exhibit A, any affiliates of any of the foregoing, and their respective agents, contractors, officers, servants, partners, shareholders, employees, successors and assigns (collectively, the “Related
Parties”) for any loss or damage that may occur to or within the premises of the buildings or any improvements thereto, or any personal property of such Client therein which is insured against under any insurance policy actually being
maintained by such Client from time to time, even if not required, or which would be insured against under the terms of any insurance policy required to be carried or maintained by such Client, whether or not such insurance coverage is actually
being maintained, including, in every instance, such loss or damage that may be caused by the negligence of Landlord and/or the Related Parties; and (ii) agrees to cause appropriate clauses to be included in all of its insurance policies as
necessary. 
 18. Insurance Requirements Waiver: Clients of certain services from CIC may be able to waive the insurance requirements detailed in
Section 14 and all applicable Exhibits. In order to waive the insurance requirement, CIC must give prior written consent to the Client by both parties fully executing CIC’s Client Insurance Requirements Waiver Amendment. 

19. Maintenance: The Client agrees to maintain the office in good condition, damage by normal wear and tear, fire and other casualty only excepted, and
acknowledges that the office is now in good order. The Client shall not permit the office to be overloaded, damaged, stripped or defaced.

 

  

							
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 20. Emergency Procedures: Client management should inform all their employees of the life safety policies
and emergency procedures of the buildings it uses, and conduct periodic training regarding the same. Information pertaining to each building’s emergency procedures is available in Exhibit A. A representative of the buildings’ management is
available to participate in Client safety and security awareness sessions. While CIC’s employees and employees of CIC’s other clients may be available to offer assistance in the event of an emergency, Client’s management should be
aware that these individuals are not trained safety professionals, and cannot be relied upon to provide error-free assistance. 
 21. Blocking or
Obscuring Interior Views, and other Alterations: CIC’s architectural design incorporates specific look and feel features intended to promote a sense of energy, open-ness and connection within CIC’s spaces. For this reason, clients may
not obstruct glass openings/views into and out of workspaces, except as approved in writing by CIC. Fully blocking views into a space is possible when unavoidable, but there is a non-trivial fee associated with doing so. 

The Client shall not make any alterations or additions to the office without the prior written consent of CIC and shall never make
structural alterations or additions. All allowed alterations shall be at Client’s expense and shall be in quality at least equal to the present construction. Client shall not permit any mechanics’ liens, or similar liens, to remain upon
the leased office for labor and material furnished to Client or claimed to have been furnished to Client in connection with work of any character performed or claimed to have been performed at the direction of Client and shall cause any such lien to
be released of record forthwith without cost to CIC or the Licensors. Any alterations or improvements made by the Client shall become the property of CIC and the Licensors upon termination of this Agreement. 

22. Assignment and Rights and Notifications Concerning Invitees: The Client shall not assign this Agreement without CIC’s prior written consent.
Notwithstanding such consent, Client shall remain liable to CIC and the Licensors for the payment of all charges and for the full performance of the covenants and conditions of this Agreement. Also notwithstanding such consent, to the extent that a
court order, secured credit contract, sale, invitation by the Client for other parties to use CIC’s facilities as their offices with or without informing CIC, or other process, introduces new parties which become owners or responsible parties
for Client and/or property stored at the CIC’s Premises, Client agrees that such parties are bound to this Agreement, will take such steps as necessary to perfect this, and will notify CIC of the names and contact information for the same
parties. These parties shall in all cases be deemed to be signatories to this Agreement by virtue of having taken an interest in property located in the Premises or by virtue of having commenced to use CIC’s services in their own right. 

        CIC may assign this Agreement to a successor in its discretion. 

This Agreement entitles the Client to receive the services identified by location in Exhibit A. The Client shall not cause or permit any
other persons or entities present at CIC’s Premises by the Client’s invitation or consent, whether affiliated with the Client or otherwise, to operate an office or

 
conduct a separate business out of CIC’s Premises unless the invitees have entered into an agreement with CIC to do so. CIC shall have sole discretion as to whether others may be added as
additional parties to this Agreement. In the event the Client allows any invitee to operate an office or conduct a business out of CIC’s Premises without CIC’s permission or modification of this Agreement, the Client hereby agrees on
behalf of itself and its insurers that it will defend and indemnify CIC and the Licensors with respect to the invitee to the same extent required under this Agreement with respect to the Client. To avoid any potential confusion concerning whether
certain entities are invitees, the Client shall provide CIC with documentation concerning any of its corporate name changes or DBA filings within thirty (30) days of filing. If Client wishes to do business at CIC’s facility under a name
other than its legal name, (e.g. by accepting mail under that other name or by using that other name on the sign on its work area entry, etc.) Client agrees to register such name with the local governing authority as a DBA. 

23. Subordination: This Agreement shall be subject and subordinate to any and all leases, mortgages deeds and other instruments in the nature of a
lease, mortgage or deed, existing now or at any time hereafter, a copy of such shall be furnished to Client at Client’s request, a lien or liens on the property of which the office is a part and the Client shall, as requested by CIC, promptly
execute and deliver such written instruments as shall be necessary to show the subordination of this Agreement to said lease, mortgage, deed or other such instruments in the nature of a lease, mortgage or deed. Termination of the Licensors’
lease or leases with the owner of the Premises will terminate this Agreement and all of CIC’s and Licensors’ obligations to the Client. 

If the building in which your office is located or the Premises leased to the Licensors are destroyed by fire or other cause such that the
owner of the building determines not to rebuild the same or exercises any right it may have to terminate Licensor’s lease, this Agreement shall expire at such time as the Licensors’ interest in the building is terminated and Client
thereupon shall surrender its office to CIC and shall pay all charges through the time of such termination. In the event that such owner shall decide to restore or rebuild the building, and the Licensors’ interest in the building under their
lease is not terminated, this Agreement shall remain in full force and effect; however, the charges payable hereunder shall be abated in proportion to the time in which Client has been deprived use of its office. In no event shall CIC or the
Licensors be liable to Client for any loss or damage occasioned by such fire or other cause. 
         If the whole
or substantially the whole of a building in which your office is located is condemned or taken in any manner for any public or quasi-public use or purpose, this Agreement shall cease and terminate as of the date of the taking of possession for such
use or purpose. If less than the whole or substantially the whole of such building shall be so condemned or taken, whether or not Client’s office is affected, then CIC may, at its option, terminate this Agreement as of the date of the taking of
possession of such use or purpose by Notice to Client. Upon any such taking or condemnation and this Agreement continuing in force, the fees payable by the Client hereunder

 

  

							
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shall be abated in proportion to the time in which Client has been deprived use of its office. Client shall have no claim arising from any such taking and, without limitation, no claim against
any proceeds paid on account of such taking. 
 24. Termination: In addition to the termination provisions contained in Section 1, CIC may also
terminate this Agreement, including but not limited to the Client’s access to the Premises, immediately at any time after the following: 

(a) Upon ten (10) calendar days’ following Notice of delinquency the Client shall fail to pay any charge or other sum due under
this agreement; or 
 (b) The Client shall default in the observance or performance of any other of the Client’s covenants,
agreements, or obligations hereunder and such default shall remain uncured after ten (10) calendar days’ following Notice of the same; or 

(c) The Client shall be declared bankrupt or insolvent according to law, or, if any assignment shall be made of Client’s property for
the benefit of creditors, or 
 (d) Client makes a material mis-representation to CIC 

25. Holdover: Should Client fail to remove its effects and vacate CIC’s Premises following the termination of this Agreement, the Client will be
obligated to pay CIC 200% of its regular rates, pro-rated by days, until the date Client vacates CIC’s Premises. 
 26. Notice: Notice
(“Notice”) shall be defined as any notice that is delivered in writing, either by hand, by e-mail, or by physical mail to one or more responsible parties at the Client, provided that there is a reasonable record kept thereof as relating to
both the date of the communication and as to the content thereof. Such a reasonable record can include printed or electronic copies of said communications. Any Notice under this Agreement that is sent by mail shall be deemed received, if properly
addressed, three (3) business days after any such Notice is deposited in the United States mail certified, postage-prepaid, return-receipt requested. If the Client’s address as set forth in Exhibit C is given as blank or as being within
the Premises, then Notice shall be deemed received if delivered by hand to CIC’s mailbox within the Premises. Any Notice under this Agreement that is sent by e-mail shall be deemed received, if delivered to the address set forth in Exhibit C or
another address reasonably believed by CIC as being that of a responsible party at the Client, three (3) business days after any such Notice is sent, provided that no automatic response has been received from the recipient’s e-mail system
indicating non-receipt of the email message or unavailability of the recipient. No oral communication shall be deemed a Notice under this Agreement. 

27. Surrender: The Client shall, prior to the expiration or other termination of this Agreement, remove all of the Client’s goods and effects from
CIC’s Premises. Client shall deliver to CIC all keys and access cards thereto. Improvements and

 fixtures permanently affixed to the CIC’s Premises shall become property of CIC and may not be removed upon
departure without express permission. In the event that any property remains in the office after termination for any reason, it shall be deemed that it was the Client’s intent that it becomes the property of CIC, to use, sell or dispose of as
it sees fit. 
 28. Non-solicitation of Employees of CIC: Client hereby acknowledges that employees of CIC and its affiliates have been carefully
selected and/or received training from CIC and agrees not to employ or solicit for employment any employee of CIC or its affiliates for a period of 12 months following termination of this Agreement and further agrees that in any case if such
employee is hired, Client shall pay CIC the sum equal to the employee’s annual salary previously paid to employee by CIC as liquidated damages. 

29. Choice of Law: The parties agree that the interpretation, instruction and enforcement of this contract shall be governed by the laws of the
Commonwealth of Massachusetts. The parties have selected Massachusetts law for reasons including (i) CIC’s having its headquarters and place of organization in Massachusetts, and (ii) ensuring predictability and uniformity in
interpretation, instruction and enforcement of this contract where licenses and privileges granted hereunder may involve Premises in more than one state. 

30. Disputes and Arbitration Agreement: CIC and Client mutually agree that any controversy or claim arising out of or relating to any aspect of the
Client’s relationship with CIC, the Licensors, or their respective officers, employees, agents, Landlords, other Clients or property manager, whether directly related to this Agreement or not, and whether arising before or after the date of
this agreement, which could have been brought in a court of law (“Covered Disputes”), shall be settled by arbitration administered by the American Arbitration Association (“AAA”), and judgment upon the award rendered by the
arbitrator may be entered in any court having jurisdiction thereof. Covered Disputes include all claims, rights, demands, losses, and causes of action rising: in contract, whether express or implied; or in tort; or under any common law theories; or
under any covenants of good faith and fair dealing; or under any CIC policy; or under any federal, state, or municipal statute, executive order, regulation or ordinance. This arbitration agreement shall not prohibit actions solely seeking injunctive
relief necessary to protect either party’s rights. With the exception of actions set forth above, arbitration shall be the exclusive means through which CIC and Client may seek relief in connection with any Covered Disputes. CIC and Client
expressly waive their right to a trial by judge or by jury of any Covered Dispute, as well as their right to appeal the decision rendered by the arbitrator except on the grounds that the decision was procured by corruption, fraud or other undue
influence or on the grounds specifically set forth in a statute applicable to vacating an arbitration award under this arbitration agreement. Client agrees that if Client wishes to assert a claim against CIC or the Licensors, the Client must present
to CIC a written request for arbitration within 6 months of the date on which the Client knows or should have known of the Covered Dispute against CIC or the Licensors. Likewise,

 

  

							
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 CIC must present a written request for arbitration to the Client against whom it wishes to assert a claim within
the same time frame. Failure by either the Client or CIC to present such a request within this time shall constitute a waiver of the right to recover relief in any forum in connection with the Covered Dispute. Unless otherwise agreed to by Client
and CIC, the arbitration shall take place in AAA’s office closest to CIC’s headquarters. CIC and Client shall select a single arbitrator in accordance with applicable AAA real estate arbitration rules. The party bringing the dispute to
arbitration shall cover all costs of the arbitration until such time as the arbiter may choose to allocate costs differently. CIC and Client are entitled to discovery sufficient to adequately arbitrate their Covered Disputes, including, but not
limited to, access to essential documents and witnesses, as determined by the arbitrator. The arbitrator shall apply the law designated in this Agreement. The arbitrator shall have the discretion to award monetary and other damages, or to award no
damages, and to fashion any other relief that would otherwise be available in court. The arbitrator will issue a written arbitration decision that reveals the essential findings and conclusions on which the award is based. This arbitration provision
shall survive the termination of this Agreement. 
 31. Use of CIC-collected Data for Academic Research: Our community is unique and its dynamics
have garnered interest in the academic research community for the purpose of studying the nature of work, economic development, business formation and growth, etc. Unless Client initials here

, Client hereby grants CIC the right to employ such data as we may collect about Client for academic research purposes, provided that no personally identifiable data relating to the Client or its parties shall be
published as part of such research. 
 32. Image capture: CIC policy prohibits anyone from capturing images showing people or client property within
private, lockable work areas without advance permission. CIC policy also requires anyone capturing images in common areas (including common work areas such as co-working and dedicated space in open areas) that include close-up images of individuals
or their property to obtain advance permission. Client hereby provides permission for their image and any signage to appear incidentally in general, pan-type (non-close up) images captured within common and shared areas. Continuous or automatic
image-capture devices (e.g. Google Glass and similar devices) must be set to not-capturing mode while within CIC Premises given that close-up shots of individuals cannot be avoided. 

33. Representations: Client represents that it is not presently in default of an obligation to a third party lessor or licensor, nor would it be as a
consequence of signing this Agreement. 
 34. Notice of Modifications to this Agreement: Maintaining a safe and productive work environment such as
CIC will require adjustments to the terms defined in this Agreement from time to time. In the event that CIC needs to make changes to this agreement, CIC will provide written Notice of such changes in the form of an Amendment to the Service
Agreement. You have

 
30 days to review such changes. If you have not informed CIC in writing that they are not acceptable within the 30 days, you and we agree to deem that you have found them acceptable, and they
will henceforth automatically be incorporated into, and form part of this Agreement. If you do not find the changes acceptable you must provide CIC Notice of that fact within 30 days of receipt of our Notice. In this instance, CIC will not apply
these modifications to your Agreement. 
 35. Nature of Agreements: CIC and Client agree that any oral discussion regarding modifying this Agreement
shall be deemed by both parties to be exploratory in nature, and shall be binding on the parties only when reduced to writing and acknowledged in writing by both parties as agreed. This shall be the case even if one or both parties begin to operate
on the basis of an oral discussion as though such discussion represented a definitive agreement. “In writing” shall include agreements reached and acknowledged by email, wherein stored electronic copies of emails shall be considered
adequate evidence of said agreement. Failure of either party to enforce any provision of this Agreement shall not constitute a waiver of that term of the Agreement, and such provision may be enforced later, at any time, without prejudice. Client and
CIC acknowledge and agree for the benefit of the Licensors identified on Exhibit A (i) that CIC Innovation Communities, LLC is acting hereunder as duly authorized agent for the Licensors of the relevant Premises identified on Exhibit A, with
the power to enter into and enforce this Agreement on behalf of such Licensors, (ii) that Client is bound to CIC and such Licensors under this Agreement, and (iii) that all fees and other amounts paid by Client hereunder for use of space
or services at a particular Premises are the property of the Licensor of such Premises identified on Exhibit A. 

 

			
	SIGNATURE BLOCK
	
	Name of Licensee’s legal entity:
	
	Summit Therapeutics
Inc                                         
               
	
	Client federal tax ID#:
22000821                                       
    
	(if left blank, Agreement becomes a personal obligation of signer)
		
	Signature:   	 	

			
		 	                                     
                                         
               
	
	Name of authorized signer: Melissa Strange                         
	
	Title: Secretary and
Treasurer                                        
       
	
	DATE:
1/14/2015                                        
                          
	
	CIC Innovation Communities, LLC (“CIC”), as agent
	
	Signature:                                 
                                         
    
	
	Officer’s
name:                                        
                             
	
	Title:                                  
                                         
           

  

 

  

							
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 This Exhibit A lists the individual services, conditions, Licensors, Landlords, insurance requirements including required
Additional Insureds, and so forth for each CIC location. Some of this information is incorporated into your Service Agreement by reference, with respect to the individual location in which you operate. As additional CIC locations are added, the
corresponding Exhibit A information for those locations will be posted online at www.cic.us/exhibita. As stated in your Service Agreement, if you elect to use space in one of those locations, the information in the most up to date online Exhibit A
shall pertain and apply to your Service Agreement. 
 Site Specifications: Cambridge Campus 

Licensors: CIC One Broadway, LLC (Licensor at One Broadway) and 101 Main CIC, LLC (Licensor at 101 Main St.)  

Landlords: MIT One Broadway, LLC (Landlord at One Broadway) and RREEF America REIT II Corp. PPP (Landlord at 101 Main St.) 

Entities that shall be considered Additional Insured parties under the Service Agreement and required CGL endorsement (for both buildings): 

CIC Innovation Communities, LLC d/b/a CIC; CIC Innovation Services, LLC; CIC One Broadway, LLC; 101 Main CIC, LLC; CIC USA Holdings, LLC; The Cambridge
Incubator, Inc.; MIT One Broadway Fee Owner, LLC; MIT One Broadway, LLC; Colliers Meredith & Grew, Inc.; RREEF America REIT II Corp. PPP; RREEF Management LLC & RREEF America, LLC; CB Richard Ellis, Inc.; CB Richard Ellis-NE
Partners, LP; Venture Cafe Foundation, Inc.; and any other entity that CIC Innovation Communities, LLC may require as an Additional Insured pursuant to CIC’s Notice to Licensee. 

Building Details: 
 

 One Broadway, Cambridge, MA 02142 
 The building provides HVAC services during normal business hours and for the first half
of Saturday. At other times the building can provide HVAC services upon request at the building’s current per-hour rate. Please be aware that it can get very warm in the building on hot summer weekends if cooling is not requested. 

For purposes of insurance, the insurer may wish to have the following information: 
  

	 	•	 	The building was built in 1969 

  

	 	•	 	The structure is steel girder with concrete skin 

  

	 	•	 	 3⁄4 of floors have had electrical, plumbing, ductwork redone since 2000 

 

	 	•	 	The roof was redone since 2000 

  

	 	•	 	New chillers and cooling towers since 2000 

  

	 	•	 	The building is equipped with fire suppression sprinklers and fire alarms. 

  

	 	•	 	Keep in mind that Licensee’s insurance needs to cover their activities anywhere in the facility (not just in their private work area). 

 101 Main, Cambridge, MA 02142 
 The landlord will provide heating, ventilation, and air conditioning Monday through Friday
from 8:00a.m. until 6:00p.m. and Saturday from 8:00a.m. until 12:00p.m. at no additional charge. After hours HVAC will be provided by the Landlord at their hourly rate per heat pump per hour with a minimum charge per request. 

For purposes of insurance, the insurer may wish to have the following information: 
  

	 	•	 	The building was built in 1983 

  

	 	•	 	The structural system is steel frame with brick façade 

  

	 	•	 	 3⁄4 of floors have had electrical, plumbing, ductwork redone since 2005 

 

	 	•	 	The upper roof housing the cooling towers was replaced in 2009 

  

	 	•	 	Cooling tower was replaced in 1999 

  

	 	•	 	The building is equipped with fire suppression and fire alarms. 

  

							
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 -Emergency Procedure 

A copy of the Cambridge Buildings’ emergency procedures is available at http://cic.us/cambridge-emergency-procedures 

 

			
	Overview of Offerings/Access – Cambridge Campus
		
	 Office Rental Space
		CIC’s offering includes flexible, expandable office space configured for use by companies of all shapes and sizes. We provide access control using electronic keys and recorded video. All normal office utilities and services,
such as electricity, office-hours HVAC, trash pickup, etc. are included. Access is available on a 24 x 7 x 365 basis. Clients choosing the Flex Space and International Flex Space clients may have limitations on the numbers of hours they can access
CIC.
		
	 Office Furniture
		Each individual with dedicated space is provided with a complete workstation, including a desk, adjustable office chair and locking file storage space. Additional furniture such as whiteboards or shelving is available in most
instances at no extra charge. Clients without dedicated space will have access to shared work areas.
		
	 Guest Reception
		All dedicated space offerings, as well as Flex Space and International Flex Space, include guest reception services to greet guests for clients. Co-working clients should greet their own guests.
		
	 Internet
		Each individual is provided with a high-speed Internet connection for office use. CIC holds its own ARIN-assigned IP address block and maintains two high-speed connections (redundant fiber Ethernet with separate paths and points of
entry) to the Internet and provides BGP-based routing redundancy. Internet services (e.g. un-firewalled IPs) are subject to availability and may incur additional charges.
		
	 Phone Services
		Each individual is given a high-end digital business telephone and a direct-dial dedicated phone number. Normal local and domestic long distance phone usage is included in the package on an unmetered basis (you will not be billed
for your domestic phone calls). Our phone system provides computerized voice-mail with local and remote access. International calls carry a separate charge. They are billed at Verizon’s discounted “Talk to the World” rates. You are
welcome to use free VOIP services such as Skype. This service is not provided for co-working clients.
		
	 Mail Services
		All dedicated space offerings as well as Flex Space and International Flex Space include a mail folder and mail services, details of which are outlined in Section 5. Co-working clients do not receive mail services, but can obtain
them for an additional monthly fee.
		
	 Copier, Printer & Fax
		Service includes unmetered use of black and white and color printers, commercial-grade copiers and fax machines for typical office use. For non-co-working clients, a private fax number, which routes faxes to an individual email
address as pdf files, is provided for the dedicated use of your company. Additional numbers are available for a fee. Questions about printing multiple copies of brochures or extensive print jobs should be directed to a CIC staff member as these
types of jobs may be requested to be taken to offsite printing service providers.
		
	 Conference Rooms
		Service includes unmetered,, use of well-appointed conference rooms with data projectors or projection screens as well as unmetered use of digital Polycom audio and video conferencing equipment. Conference rooms and phonebooths are
booked via a web-based booking tool. Questions regarding frequent all-day meetings or intensive use for training or other purposes can be directed to a CIC staff member for details. Co-working clients are limited to co-working conference rooms
during regular business hours.
		
	 Payment Requirements
		CIC prefers payment by ACH automatic debit, and this method is required for the co-working offering.

  

							
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	General Liability Insurance Requirements		Dedicated space clients are required to provide evidence of insurance coverage. Clients who are not taking dedicated space, for example, Flex Space or co-working clients, may submit a Waiver Amendment for Client Insurance
Requirements.
		
	 Kitchen Services
		CIC has fully stocked kitchens, which often include yogurts, fruits, soft drinks, and other snacks and cold beverages. CIC also stocks a full selection of gourmet coffees and a high-end by-the-cup coffee brewing system. This service
is included in your service fee and fair consumption is on the honor system.
		
	 Massage Therapy
		CIC maintains a massage therapy room and has a relationship with independent professional massage therapists who come in on a regular basis. CIC provides use of the massage room without charge. All fees for massage go solely to the
therapist, and are not billed through CIC. Use of this service is at client discretion, and CIC is not liable.
		
	 Wellness Programs
		CIC has different wellness programs that change pending interest and season. Currently there is a Running Club that gathers each Tuesday and a weekly onsite yoga class, which does involve an additional fee paid directly to the
teacher.
		
	 Shower Rooms
		CIC has several shower rooms available to clients on a first come first served basis. The shower rooms are stocked with towels and toiletries.
		
	 Venture Café
		Venture Cafe: The Venture Cafe is a community networking event held every Thursday at CIC from 3:00pm-8:00pm and hosted by the nonprofit Venture Café Foundation. With its “pay it forward” Contributor Model, Venture
Cafe is hosted at CIC to bring together members of the local entrepreneurial and innovation community. Clients of CIC receive direct access to this weekly event. Along with hosted beer and wine, weekly Venture Cafes often include guest speakers,
workshops, et al. Please note, it is a privilege and not a right to attend these gatherings, and the Venture Café Foundation reserves both the right to refuse service and to determine, at its sole discretion, who to invite according to its
mission and policies.
		
	 Artisan’s Asylum
		CIC clients have access to Artisan’s Asylum, a nonprofit community craft studio located at 10 Tyler Street in Union Square in Somerville, MA. The facilities include capabilities for precision metal machining, electrical
fabrication, welding, woodworking, sewing and fiber arts, robotics, bicycle building and repair, and screenprinting. All shared equipment requires either proof of proficiency or training by a certified Artisan’s Asylum shop tech. The costs for
classes, workshops, and training are the responsibility of the client.

 Site Specifications: Boston - 50 Milk Street, Boston, MA 02109 

Licensors: CIC 50 Milk, LLC (Licensor at 50 Milk St.), Hub for Change, LLC d/b/a Impact Hub Boston (Licensor at 50 Milk St.), Landlord: Ponte
Gadea Boston, LLC (Landlord at 50 Milk St.) 
 Entities that shall be considered Additional Insured parties under the Service Agreement and required CGL
endorsement: 
 CIC Innovation Communities, LLC d/b/a CIC; CIC Innovation Services, LLC; CIC 50 Milk, LLC; CIC USA Holdings, LLC; The Cambridge
Incubator, Inc.; Ponte Gadea Boston, LLC; Ponte Gadea Florida; CB Richard Ellis-N.E. Partners, LP; Venture Cafe Foundation, Inc.; Hub for Change, LLC d/b/a Impact Hub Boston; and any other entity that CIC Innovation Communities, LLC may require as
an Additional Insured pursuant to CIC’s Notice to Licensee. 

  

							
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 Building Details: 

The building provides HVAC services from 8 am to 7 pm during business days, and from 8 am to 1 pm on Saturday. At other times, the building can provide HVAC
services by request at the building’s current per-hour. Please be aware that it can get very warm in the building on hot summer weekends if cooling is not requested. 

For purposes of insurance, the insurer may wish to have the following information: 
  

	 	•	 	The building was built in 1980 

  

	 	•	 	The structure is steel girder, concrete slab floors, granite façade with aluminum framed windows 

  

	 	•	 	The main roof was redone around 2002; the penthouse roof was installed circa 1984 

  

	 	•	 	Cooling towers, main air handlers and HVAC pumps were newly installed in 2014 

  

	 	•	 	Fire alarm system headend was upgraded in 2014 

 -Emergency Procedure 

A copy of the building’s emergency procedures is available at http://boston.cic.us/emergency-procedures 

 

			
	Overview of Offerings/Access - Boston
		
	 Office Rental Space
		The CIC offering includes flexible, expandable office space configured for use by companies of all shapes and sizes. We provide access control using electronic keys. All normal office utilities and services, such as electricity,
office-hours HVAC, trash pickup, etc. are included. Access is available on a 24 x 7 x 365 basis. Clients choosing the Flex Space and International Flex Space offering may have limitations on the numbers of hours they can access CIC.
		
	 Office Furniture
		Each individual with dedicated space is provided with a complete workstation, including a desk, adjustable office chair and locking file storage space. Additional furniture such as whiteboards or shelving is available in most
instances at no extra charge. Clients without dedicated space will have access to shared work areas.
		
	 Guest Reception
		All dedicated space offerings as well as Flex Space and International Flex Space include guest reception services to greet guests for clients.
		
	 Internet
		Each individual is provided with a high-speed wired Internet connection for office use, as well as WiFi. Other internet services (e.g. un-firewalled IPs) are subject to availability and may incur additional charges.
		
	 Phone Services
		Each individual is given a high-end digital business telephone and a direct-dial dedicated phone number. Normal local and domestic long distance phone usage is included in the package on an unmetered basis (you will not be billed
for your domestic phone calls). Our phone system provides computerized voice-mail with local and remote access. International calls carry a separate charge. They are billed at Verizon’s discounted “Talk to the World” rates. You are
welcome to use free VOIP services such as Skype.
		
	 Mail Services
		All dedicated space offerings as well as Flex Space and International Flex Space include a mail folder and mail services, details of which are outlined in Section 5.
		
	 Copier, Printer & Fax
		Service includes unmetered use of black and white and color printers, commercial-grade copiers and fax machines for typical office use. A private fax number, which routes faxes to an individual email address as pdf files, is
provided for the dedicated use of your company. Additional numbers are available for a fee. Questions about printing multiple copies of brochures or extensive print jobs should be directed to a CIC staff member as these types of jobs may be
requested to be taken to offsite printing service providers.

  

							
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	Conference Rooms		Service includes unmetered use of well-appointed conference rooms with data projectors or projection screens as well as unmetered use of digital Polycom audio and video conferencing equipment. Conference rooms and phonebooths are
booked via a web-based booking tool. Questions regarding frequent all-day meetings or intensive use for training or other purposes can be directed to a CIC staff member for details.
		
	 General Liability Insurance

Requirements
		Dedicated space clients are required to provide evidence of insurance coverage. Clients who are not taking dedicated space [for example, Flex Space and International Flex Space], may submit a Waiver Amendment for Client Insurance
Requirements.
		
	 Kitchen Services
		CIC has fully stocked kitchens, which often include yogurts, fruits, soft drinks, and other snacks and cold beverages. CIC also stocks a full selection of gourmet coffees and a high-end by-the-cup coffee brewing system. This service
is included in your service fee and fair consumption is on the honor system.
		
	 Shower Rooms
		CIC has several shower rooms available to clients on a first come first served basis. The shower rooms are stocked with towels and toiletries.
		
	 Venture Café
		Venture Cafe: The Venture Cafe is a community networking event held every Thursday at CIC Cambridge from 3:00pm-8:00pm, and hosted by the nonprofit Venture Café Foundation. With its “pay it forward” Contributor
Model, Venture Cafe is hosted at CIC to bring together members of the local entrepreneurial and innovation community. Clients of CIC receive direct access to this weekly event. Along with hosted beer and wine, weekly Venture Cafes often include
guest speakers, workshops, et al. Please note, it is a privilege and not a right to attend these gatherings, and the Venture Café Foundation reserves both the right to refuse service and to determine, at its sole discretion, who to invite
according to its mission and policies.
		
	 Artisan’s Asylum
		CIC clients have access to Artisan’s Asylum, a nonprofit community craft studio located at 10 Tyler Street in Union Square in Somerville, MA. The facilities include capabilities for precision metal machining, electrical
fabrication, welding, woodworking, sewing and fiber arts, robotics, bicycle building and repair, and screenprinting. All shared equipment requires either proof of proficiency or training by a certified Artisan’s Asylum shop tech. The costs for
classes, workshops, and training are the responsibility of the client.

 Site Specifications: CIC@4240 

Licensor: CIC 4240, LLC 
 Landlord: Wexford Heritage
MT, LLC c/o Wexford Science & Technology, LLC 
 Entities that shall be considered Additional Insured parties under the Service Agreement and
required CGL endorsement: 
 CIC Innovation Communities, LLC d/b/a CIC; CIC Innovation Services, LLC; CIC 4240, LLC; CIC Forest Park, LLC; CIC University
Projects, LLC; CIC USA Holdings, LLC; The Cambridge Incubator, Inc.; Venture Cafe Foundation, Inc.; the Center for Emerging Technologies; the Land Clearance for Redevelopment Authority of the City of Louis; St. Louis Development Corporation; the
U.S. Economic Development Administration; the Missouri Development Finance Corp.; the Missouri Department of Economic Development; Midwest BankCentre; Wexford Heritage MT, LLC c/o Wexford Science & Technology, LLC; Wexford Heritage, LLC;
BioMed Financing, LLC; BioMed Wexford Realty Trust, Inc.; BioMed Realty, LP; BioMed Realty Holdings II, Inc.; Cassidy Turley Commercial Real Estate Services, Inc.; SLLC Real Estate II, LLC; Center for Research Technology and Entrepreneurial
Exchange; and any other entity that CIC Innovation Communities, LLC may require as an Additional Insured pursuant to CIC’s Notice to Licensee. 

  

							
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 Additionally, all such CGL must have the following coverages and limits: 

 

	 	(a)	Products and Completed Operations: $1,000,000 

  

	 	(b)	General Aggregate: $2,000,000 

  

	 	(c)	Personal Injury/Advertising Injury Liability: $1,000,000 

  

	 	(d)	Per Occurrence: $1,000,000 

  

	 	(e)	Fire Legal Liability: $300,000 ($1,000,000 required for lab spaces) 

  

	 	(f)	Medical Payments: $5,000 

  

	 	(g)	Contractual Liability (including contractual indemnity): $1,000,000 

  

	 	(h)	General Liability coverage is primary & non-contributory 

 Building Details: 

The building provides HVAC services 24/7. 
 For purposes of
insurance, the insurer may wish to have the following information: 
  

	 	•	 	The construction type: brick 

  

	 	•	 	Year built: 1947 

  

	 	•	 	Sprinkler system: Installed in February 2013 in accordance with NFPA 13 and NFPA 14, 2009 IBC building code installation in compliance with City of St. Louis Fire Code requirements. This is the same time the building
was converted from warehouse to office. 

 -Emergency Procedures: 

A copy of the building’s emergency procedures is available at: http://stl.cic.us/emergency-procedures 

Additional Agreement Provisions: 
 The following language
is included in any Agreement with respect to this site: “Client shall comply with that certain policy, as the same may be reasonably amended from time to time, established by the non-profit Center of Research Technology and Entrepreneurial
Exchange (“CORTEX”), or its affiliate, regarding the provision to CORTEX of notices of job openings at the Premises, which job opening information may be posted or published by CORTEX and forwarded to appropriate governmental
agencies.” 
  

			
	Overview of Offerings/Access – CIC@4240
		
	 Office Rental Space
		CIC offering includes flexible, expandable office space configured for use by growing companies. We provide access control using electronic keys and recorded video. All normal office utilities and services, such as electricity,
office-hours HVAC, trash pickup, etc. are included. Access is available on a 24 x 7 basis. Only Flex Space and International Flex Space clients have limitations on the numbers of hours they can access CIC.
		
	 Office Furniture
		Each individual with dedicated space is provided with a complete workstation, including a desk, adjustable office chair and locking file storage space. Additional furniture such as whiteboards or shelving is available in most
instances at no extra charge. Clients with no dedicated space will have access to shared work areas.
		
	 Guest Reception
		All dedicated space offerings as well as Flex Space include guest reception services to greet guests for clients.
		
	 Internet
		Each individual is provided with a high-speed wired Internet connection for office use, as well as WiFi. Other internet services (e.g. un-firewalled IPs) are subject to availability and may incur additional charges.
		
	 Phone Services
		Each individual is given a high-end digital business telephone and a direct-dial dedicated phone number. Normal local and domestic long distance phone usage is included in the package on an unmetered basis (you will not be billed
for your domestic calls). Our phone system provides computerized voice-mail with local and remote access. International calls carry a separate charge.

  

							
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	 Mail Services
		All dedicated space offerings, as well as Flex Space, include a mail folder and mail services, details of which are outlined in Section 5.
		
	 Copier, Printer & Fax
		Service includes unmetered use of black and white and color printers, commercial-grade copiers and fax machines for typical office use. A private fax number, which routes faxes to an individual email address as pdf files, is
provided for the dedicated use of your company. Additional numbers are available for a fee. Questions about printing multiple copies of brochures or extensive print jobs should be directed to a CIC staff member as these types of jobs may be
requested to be taken to offsite printing service providers.
		
	 Conference Rooms
		Service includes unmetered use of well-appointed conference rooms, some which include Apple TV for wireless data projection from Apple devices, as well as unmetered use of Polycom speaker phones. Conference rooms and phonebooths are
booked via webpage. Questions regarding frequent all-day meetings or intensive use for training or other purposes can be directed to a CIC staff member for details.
		
	 General Liability Insurance

Requirements
		Dedicated space clients are required to provide evidence of insurance coverage. Clients who are not taking dedicated space [for example, Flex Space], may submit a Waiver Amendment for Client Insurance Requirements.
		
	 Kitchen Services
		Clients will be able to enjoy various snacks and a selection of soda, gourmet coffees and a high-end by-the-cup coffee brewing system. Fair consumption is on the honor system.
		
	 Shower Rooms
		CIC has several shower rooms available to clients on a first come first served basis. The shower rooms are stocked with towels and toiletries.
		
	 Venture Café
		The Venture Café will be a community networking event hosted by the Venture Café Foundation, most Thursdays from 3:00pm-8:00pm at CIC@4240. With its “pay it forward” Contributor Model, the Venture Café
Foundation was established to bring together members of the local entrepreneurial and innovation community. CIC clients receive direct access to this weekly event. Along with hosted beer and wine, weekly Venture Cafés often include speakers,
workshops, et al.
		
	 Educational Programs
		Clients of CIC@4240 will be able to attend educational programs hosted by the Center for Emerging Technologies (at CIC@CET) at little to no cost. CIC@4240 clients also have access to on-site mentors for support via CET’s
programming or through CIC’s partner non-profit Venture Café (details above).

  

							
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 Automatic Debit 

 

ACH PAYMENT SYSTEM 

The Automatic Bank Debit system enables you to have your monthly payment automatically drafted from your bank account.

 Please fill out the information listed below. 
  

					
	 Licensee Name:
		     Summit Therapeutics Inc
		                                    
        

 Licensee hereby agrees to incorporate the ACH
authorization form (Schedule B) of the previous Service Agreement between Licensee and The Cambridge Incubator Inc. (herein the “Previous Agreement”) as Exhibit B to this Agreement between the Licensee and CIC Innovation Communities, LLC.
Licensee hereby authorizes CIC Innovation Communities, LLC to initiate debit entries to the bank account listed in Schedule B of the Previous Agreement for payment of amounts due under this Agreement. 

 

									
	 Licensee Signature:
		

                        		 	Date:	  		
1/14/2015                 

  

							
	 CIC Service Agreement - Version 7.0
		Page 15 of 18		Please Initial Here:  		

 

 
 Client Information 

			
		
	Licensee legal address (if blank, CIC is legal address):		
                     
    

  

			
	City:                                   
                                      State: 
                                         
                       Zip:                 
                                        

  

			
	Alternate address (if CIC is legal address):		
                     
    

		
	Contact info for Licensee (name):		
                     
    

  

							
	Cell #:		
                 
		Home #:		
                     

				
	Work Email:		
                 
		Alt. email:		
                     

  

											
	Will this person be a user (need a key)? No  ̈ Yes  ̈
	
	 For dedicated space clients only (does not include for example, co-working or flex space): Are you a Regular User  ̈ or
 Offsite Associate  ̈

	
	If “Regular” would you like a desk phone? No  ̈ Yes  ̈
	
	Note: Offsite Associates are employees of dedicated space clients that visit CIC less than 2 or 3 times a month. They can obtain a key, and there is no additional charge. Desk phones are included in the service fee
for regular dedicated space users.
	
	Please list employees of your company here who will work out of CIC and need a key:
						
	Full Name:		
                 
		Cell Phone:		
                 
		Email:		
                 

	
	For dedicated space clients,  ̈ Regular User or  ̈ Offsite Associate, If “Regular” would you like a phone? No  ̈ Yes  ̈
						
	Full Name:		
                 
		Cell Phone:		
                 
		Email:		
                 

	
	For dedicated space clients,  ̈ Regular User or  ̈ Offsite Associate, If “Regular” would you like a phone? No  ̈ Yes  ̈
						
	Full Name:		
                 
		Cell Phone:		
                 
		Email:		
                 

	
	For dedicated space clients,  ̈ Regular User or  ̈ Offsite Associate, If “Regular” would you like a phone? No  ̈ Yes  ̈
	
	Please keep in mind that any time you request that CIC provide access to CIC for any individual, you become responsible for that individual’s actions and operations under this Agreement, as though they were your
own actions and operations.

  

			
		
	Business Description (please provide detail for internal use only):		
                     
                                         
                                         
  

	
	             
        

	
	             
        

  

Does the Company go by any other name for purposes of receiving mail/guests or wish to conduct business under any other name? No  ̈ Yes  ̈ If yes, CIC will follow up.    Yes 

					
		
	How did you learn about CIC?		
                     

		
	Anticipated Move-in Date (Please specify a day and leave 48 hours for processing):		
                     
                                         
               

Note: If paying by check, please remit with this Service Agreement, otherwise deposit will be debited from the account provided in Exhibit B. In order to
obtain keys to the space, you must provide CIC with valid proof of insurance or waiver. 
 Note any additional terms here: 

CIC aims to maintain a pricing policy and fee structure that is intended to be simple and transparent. Occasionally we apply modest fee increases to our
space and service fees to keep pace with costs, which typically begin on the 1st of the year. Historically, we have been able to give current clients at least 12 months notice before any fee
increase and most fee increases have been around 3%. We will continue to try and give as much notice as possible and encourage all new clients to inquire about any planned future increases when they sign up. 

  

							
	 CIC Service Agreement - Version 7.0
		Page 16 of 18		Please Initial Here:  		

 

 
 CLIENT INSURANCE REQUIREMENTS WAIVER AMENDMENT 

As you know, CIC’s Service Agreement (Section 14) requires that you carry commercial general liability insurance. There are circumstances in which, for
one reason or another, these requirements have not been met, and yet a client continues to wish to use CIC’s services. As a convenience to our clients, we have created a client insurance waiver process to enable clients to use our facility and
services during periods when the required insurance is not in place. To be clear, we strongly recommend and prefer that clients obtain the insurance rather than employ this waiver. So long as this waiver agreement is in force, clients are permitted
to not meet the requirements in Section 14. Should this waiver agreement lapse for any reason, then the insurance requirements of the Agreement shall once again be in force. In the below agreement, “I”, “me” and
“my” refer to the entity which the undersigned represents. 
 WAIVER AGREEMENT 

1. The Service Agreement I have entered into includes a concept of a “waiver of subrogation” (Service Agreement Section 17) and the concept of
“indemnification and waiver of rights to recovery” (Service Agreement Section 16). 
 2. I understand that the “waiver of
subrogation” means, in essence, that I bear the cost of my own losses, regardless of who caused those losses. This agreement benefits me by reducing the cost of the services I can buy, by eliminating the need for CIC to quantify and insure
against all the possible losses that I might sustain. 
 3. I understand that when agreements are structured this way, generally I am required to carry my
own insurance. This is because without such insurance, there is no one else for me to turn to in the event of a loss. For example, if there was a catastrophic failure of the ventilation system at CIC, and the building suddenly became unusable, I
might sustain losses because of the unexpected loss of my workplace. Regardless of who might be responsible for that failure, I would be responsible for covering my losses. And I understand this applies to all other situations of loss, such as via
fire, theft, injury, and so forth. 
 4. Another important reason that it is advisable for me to carry insurance is that I have indemnified CIC (Service
Agreement Section 16), its associated parties, and other CIC clients against losses that may incur due to my action or inaction. I understand that “indemnification” in this case means that, for instance, if I cause a fire at any CIC
facilities, and others are hurt, I will make up for their losses. Generally, liability insurance would help me meet that obligation. 
 5. Given all this, I
understand why this Service Agreement requires me to have insurance, and why it is very advisable that I have it. 
 6. The aforementioned notwithstanding,
I have decided not to carry such insurance, and I accept the potential consequences. 
 7. I understand that CIC’s exposure to the risk that I will not
be able cover my indemnification will rise as a result of my decision, because CIC will not be afforded the same protection it would have if I had insurance. 

8. I agree that neither I nor my entity will assert that by offering me this waiver, CIC or any of its associated parties are providing me with any kind of
substitute insurance. 
 9. I understand that this waiver in no way releases me from any obligation to indemnify all parties named in Exhibit A of this
agreement, as well as other Landlord related parties and other clients against losses caused by me. 
 10. I understand that if I become a Licensee of any
dedicated office space within CIC’s Premises, this waiver shall no longer be valid, and I will need to abide by all terms of CIC’s Service Agreement pertaining to insurance. 

In witness thereof, 
 Name of Licensee legal entity: 

									
	 						
				
	Licensee Federal Tax ID#:		  
				CIC Innovation Communities, LLC, as agent
	(if left blank, agreement becomes personal obligation of signer)						
					
	Signature:		  
				Signature:		  

					
	Name of Authorized Signer:		  
				Officer’s name:		  

					
	Title:		  
				Title:		  

					
	DATE:		  
				DATE:		  

  

							
	 CIC Service Agreement - Version 7.0
		Page 17 of 18		Please Initial Here:  		

 

 
 ACORD TM 
CERTIFICATE OF LIABILITY INSURANCE

DATE (MM/DD/YYYY) 08/10/2010 
THIS CERTIFICATE IS ISSUED AS A MATTER OF
INFORMATION 
ONLY AND CONFERS NO RIGHTS UPON THE CERTIFICATE 
HOLDER. THIS
CERTIFICATE DOES NOT AMEND, EXTEND OR 
ALTER THE COVERAGE AFFORDED BY THE POLICIES BELOW. 
PRODUCER FAX 
ABC Insurance Insurance 
123 Main Street 
Anywhere, US 12345 
INSURED Your Name and Address Here 
INSURERS AFFORDING COVERAGE 
NAIC # 
INSURER A: 
INSURER B: 
INSURER C: 
INSURER D: 
INSURER E: 
COVERAGES 
THE POLICIES OF INSURANCE LISTED BELOW HAVE BEEN ISSUED TO THE INSURED NAMED ABOVE
FOR THE POLICY PERIOD INDICATED. NOTWITHSTANDING 
ANY REQUIREMENT, TERM OR CONDITION OF ANY CONTRACT OR OTHER DOCUMENT WITH RESPECT TO WHICH THIS CERTIFICATE MAY BE
ISSUED OR 
MAY PERTAIN, THE INSURANCE AFFORDED BY THE POLICIES DESCRIBED HEREIN IS SUBJECT TO ALL THE TERMS, EXCLUSIONS AND CONDITIONS OF SUCH POLICIES. AGGREGATE
LIMITS SHOWN MAY HAVE BEEN REDUCED BY PAID CLAIMS. 
INSR ADD’L TYPE OF INSURANCE POLICY NUMBER POLICY EFFECTIVE POLICY EXPIRATION LIMITS LTR INSRD DATE
(MM/DD/YY) DATE (MM/DD/YY) GENERAL LIABILITY POLICY NUMBER Eff Date Exp Date EACH OCCURRENCE DAMAGE TO RENTED COMMERCIAL GENERAL LIABILITY $1,000,000 PREMISES (Ea occurence) CLAIMS MADE OCCUR $ MED EXP (Any one person) $ PERSONAL & ADV INJURY $
GENERAL AGGREGATE GEN’L AGGREGATE LIMIT APPLIES PER: $ PRODUCTS - COMP/OP AGG PROJECT $2,000,0000 POLICY LOC 
AUTOMOBILE LIABILITY COMBINED SINGLE LIMIT $ANY
AUTO (Ea accident) ALL OWNED AUTOS BODILY INJURY (Per person) $SCHEDULED AUTOS HIRED AUTOS BODILY INJURY (Per accident) $NON-OWNED AUTOS PROPERTY DAMAGE $ (Per accident) 
GARAGE LIABILITY AUTO ONLY - EA ACCIDENT $ANY AUTO EA ACC $ OTHER THAN AUTO ONLY: AGG $EXCESS/UMBRELLA LIABILITY EACH OCCURRENCE $OCCUR CLAIMS MADE AGGREGATE $ $DEDUCTIBLE
$RETENTION $ $ 
WC STATUTORY OTHER WORKERS COMPENSATION AND LIMITS EMPLOYERS’ LIABILITY E.L. EACH ACCIDENT $ANY PROPRIETOR/PARTNER/EXECUTIVE OFFICER/MEMBER
EXCLUDED? E.L. DISEASE - EA EMPLOYEE $If yes, describe under SPECIAL PROVISIONS below E.L. DISEASE - POLICY LIMIT $OTHER 
DESCRIPTION OF OPERATIONS / LOCATIONS /
VEHICLES / EXCLUSIONS ADDED BY ENDORSEMENT / SPECIAL PROVISIONS 
CIC Innovation Communities LLC and those entities listed in Exhibit A of the Service Agreement
between the named insured and CIC Innovation Communities LLC, as it may be amended from time to time, are included as Additional Insureds on a primary and non-contributory basis under this Commercial General Liability Insurance. 
CERTIFICATE HOLDER CANCELLATION 
CIC Innovation Communities, LLC 
1 Broadway – 14th Floor 
Cambridge, MA 02142 
SHOULD ANY OF THE ABOVE DESCRIBED POLICIES BE CANCELLED BEFORE THE EXPIRATION DATE THEREOF, THE ISSUING INSURER WILL ENDEAVOR TO MAIL 30 DAYS WRITTEN NOTICE TO THE CERTIFICATE
HOLDER NAMED TO THE LEFT, BUT FAILURE TO MAIL SUCH NOTICE SHALL IMPOSE NO OBLIGATION OR LIABILITY OF ANY KIND UPON THE INSURER, ITS AGENTS OR REPRESENTATIVES.

AUTHORIZED REPRESENTATIVE 
ACORD 25 (2001/08) © ACORD CORPORATION 1988

  

							
	 CIC Service Agreement - Version 7.0
		Page 18 of 18		Please Initial Here:  		

 

 
 In regards to the previous Service Agreement entered into between Licensee and The Cambridge Incubator, Inc. (the
“Previous Agreement”), and in regards to the new Service Agreement entered into between Licensee and CIC Innovation Communities, LLC, as agent (the “New Service Agreement”), all parties hereby agree: 

 

	 	a)	The 30 day notice of termination requirement from the Previous Agreement is waived and the Previous Agreement is terminated at the time that the New Service Agreement becomes effective. 

 

	 	b)	The New Service Agreement is in effect on and as of January 1st, 2015. 

  

	 	c)	If applicable, Licensee’s Deposit from the Previous Agreement will be applied to the Deposit for the New Service Agreement. 

  

									
	Licensee Name		Summit Therapeutics Inc                           						
					
	Licensee Signature 		 

  
				Date        		 1/14/2015

					
	The Cambridge Incubator, Inc.		  
				Date		  

					
	CIC Innovation Communities, LLC, as agent    		  
		        		DateEX-10.17

 Exhibit 10.17 

PRIVATE & CONFIDENTIAL 
 Mr. David Wurzer

 18 February 2015 
 Dear David 

Non-Executive Directorship—Letter of Appointment 

Summit Therapeutics Inc (the “Employer”) hereby engages you to act as a non-executive director of Summit Corporation plc (the
“Company”). This letter confirms the main terms and conditions of your appointment to this office. 
  

	1.	Your appointment as non-executive director of the Company shall take effect from Friday 20th February 2015 (the “Effective Date”) and will
continue until terminated by mutual agreement of the parties or by any party giving written notice to the others, such notice to be effective immediately. For the avoidance of doubt, your appointment shall also be subject to the Articles of
Association of the Company from time to time in force (including without limitation any provisions requiring that all directors retire and seek re-election at each AGM or for one third of the directors to retire by rotation and seek re-election at
each AGM, with each director being subject to re-election at intervals of not more than three years) as well as the provisions of applicable legislation including the Companies Acts. 

 

	2.	You undertake that in performing any of your duties for the Company pursuant to the terms of this letter, you will not be in breach of any agreement with a third party (written or oral) or other obligation binding on
you. 

  

	3.	Your appointment will terminate forthwith without any entitlement to compensation (save as regard any unpaid fees accrued up to the date of such termination) if: 

 

	 	3.1	you are not reappointed as a director of the Company at its next Annual General Meeting; or 

	 	3.2	you are removed as a director by resolution passed at a General Meeting of the Company or otherwise as permitted by law; or 

  

	 	3.3	you cease to be a director of the Company by reason of your vacating office pursuant to any provision of the Company’s Articles of Association; or 

 

	 	3.4	you fail to be re-appointed following retirement by rotation pursuant to the Company’s Articles of Association; or 

  

	 	3.5	you are adjudged bankrupt or enter into any composition or arrangement with or for the benefit of your creditors including a voluntary arrangement under the Insolvency Act 1986 or its equivalent under the legislation of
any other territory; or 

  

	 	3.6	you are guilty of any misconduct or commit any serious or persistent breach of any of your obligations to the Company or any Group Company; or 

 

	 	3.7	you infringe the Bribery Act 2010 or any Company or Group policy or procedure relating to bribery and/or corruption or any rules or regulations imposed by any regulatory or other external authority (including the UK
Listing Authority) or professional body applicable to your employment or which regulate the performance of your duties, or any code of practice issued by the Company, or you fail to possess any qualification or meet any condition or requirement laid
down by any applicable regulatory authority professional body or legislation; or 

  

	 	3.8	you are guilty of any conduct tending in the reasonable opinion of the Board to bring yourself or the Company or any Group Company into disrepute; or 

 

	 	3.9	you are or become incapacitated from any cause whatsoever from efficiently performing your duties hereunder for 90 days in aggregate in any period of 12 months; or 

 

	 	3.10	you shall be or become prohibited by law from being a director. 

  

	4.	You will forthwith resign as a director of the Company upon the expiry or termination of this Agreement howsoever arising. You hereby irrevocably appoint any other director of the Company from time to time to be your
attorney to execute any documents and do anything in your name to effect your resignation as a director of the Company should you fail to so resign. 

  

	5.	Non-executive directors have the same general legal responsibilities to the Company as any other director. The Board as a whole is collectively responsible for promoting the success of the Company by directing and
supervising the Company’s affairs. The Board: 

  

	 	5.1	provides entrepreneurial leadership of the Company within a framework of prudent and effective controls which enables risk to be assessed and managed; 

 

	 	5.2	sets the Company’s strategic aims, ensures that the necessary financial and human resources are in place for the Company to meet its objectives, and reviews management performance; and 

	 	5.3	sets the Company’s values and standards and ensures that its obligations to its shareholders and others are understood and met. 

 

	6.	In addition to these requirements of all directors, the role of the non-executive has the following key elements as recommended following the Higgs review: 

 

	 	6.1	Strategy: non-executive directors should constructively challenge and contribute to the development of strategy; 

  

	 	6.2	Performance: non-executive directors should scrutinise the performance of management in meeting agreed goals and objectives and monitor the reporting of performance; 

 

	 	6.3	Risk: non-executive directors should satisfy themselves that financial information is accurate and that financial controls and systems of risk management are robust and defensible; and 

 

	 	6.4	People: non-executive directors are responsible for determining appropriate levels of remuneration of executive directors and have a prime role in appointing, and where necessary removing, senior management and in
succession planning. 

  

	7.	Your overall role will be to bring an objectivity and independence of view to the Board’s discussions, to help the Board provide the Group with effective leadership, as well as ensuring the continuing effectiveness
of the management team and high standards of financial probity and corporate governance, and to suggest, advise on and monitor matters relating to the business of the Company. You shall act in good faith and exercise all reasonable skill and care in
the performance of your duties. You must at all times comply with your duties as a director, the combined code and the statement of best practice on the role and duties of directors by the institutional shareholders committee. 

 

	8.	You will return all property and documents of the Company or any Group Company in your possession on the expiry or termination of this appointment and will delete permanently from any computer or device owned by you or
over which you have control (including any personal computer, laptop computer, computer server, computer network, personal digital assistant, mobile telephone, memory, disk or any other storage medium) information relating to the Company or any
Group Company or any duties or work you have carried out for the Company or any Group Company. 

  

	9.	The Employer will pay you for your services as a non-executive director of the Company at the rate of £25,000 and a further £10,000 for your role as Chairman of the Audit Committee, such fee to accrue from
day to day and to be payable quarterly in arrears, subject where applicable, to the deduction of tax and National Insurance contributions as required by law and where applicable any federal, state and/or local withholding obligations (including
income taxes and the employee portion of employment taxes) in the United States. You will not participate in any Group bonus schemes or in any other benefit in kind arrangements of the Group, nor will you be entitled to any compensation for loss of
office. 

  

	10.	In addition, the Employer will repay to you all travel and other reasonable expenses in line with the Group’s expense policy properly incurred in connection with your duties as non-executive director of the
Company, provided that you provide evidence of payment. 

	11.	You hereby indemnify the Company in respect of any claims or demands that may be made by the relevant authorities against the Company in respect of income tax or National Insurance Contributions relating to your work
for the Company together with all costs, expenses, interest and demands that may be incurred by the Company in connection with such claims or demands. 

  

	12.	The Company and the Employer will continue with any directors’ and officers’ liability insurance already in place for your benefit. Your participation in such insurance is subject always to the terms,
conditions and limitations of such insurance cover, a copy of which can be obtained from the Company Secretary. 

  

	13.	As a non-executive director of the Company, you will have the general fiduciary duties and the duty of skill and care expected of every director, and will attend periodic Board meetings and/or the meetings of such
committee(s) to which you may be appointed a member unless you are too ill to attend or your absence has otherwise been excused. You will also be expected to devote appropriate preparation time ahead of such meetings. In carrying out your duties,
you shall have particular regard to the Articles of Association of the Company from time to time in force and any specific authority delegated by the Board. 

  

	14.	During the term of your appointment you may not (except with the prior sanction of a resolution of the Board) be directly or indirectly employed, engaged, concerned or interested in, or hold any office in, any business
or undertaking which competes with any of the businesses of the Group. However, this shall not prohibit you from holding (directly or through nominees) investments listed or admitted to trading on the Official List of the United Kingdom Listing
Authority (“UKLA”) or in the Alternative Investment Market of the London Stock Exchange Plc (“AIM”) or on any other recognised investment exchange so long as you do not hold more than 5 per cent of the issued
shares or other securities of any class of any one company without the prior sanction of a resolution of the Board. 

  

	15.	During the course of your appointment you may have access to and become familiar with various secret and Confidential Information of one or more Group Companies as set out in this paragraph. You must not at any time
whether before or after the termination of your appointment as a non-executive director of the Company disclose to any person firm company or organisation whatsoever nor use, print, publish or make use of any secret or Confidential Information,
matter or thing relating to the Company or any other Group Company or the business thereof except in the proper performance of your duties or with the prior written consent of the Board or as required by law. 

 

	16.	Both during the term of your appointment and after its termination you will observe the obligations of confidentiality which are attendant on the office of director. In particular, save in the proper performance of your
duties, you will not make use or disclose to any person any Confidential Information and will use your best endeavours to ensure that no other person improperly makes use of or discloses such Confidential Information. 

 

	17.	 If applicable, you will be obliged at all times to comply both with the technical requirements and with the spirit of the Model Code of the UKLA
related to directors’ dealings together with any share dealing rules adopted from time to time by the Company. The Code is separate from the insider dealing provisions contained in Part V

	 	
of the Criminal Justice Act 1993 and from the market abuse provisions contained in section 118 of the Financial Services and Markets Act 2000, as amended from time to time and you may not at any
time enter into any transaction which contravenes those Acts irrespective of whether this should also breach the Code. 

  

	18.	You will comply with all lawful and reasonable directions of the Board and all rules and regulations of the Company, including without limitation, regulations with respect to confidentiality, dealings in shares and
notifications required to be made by a director to the Company or any relevant regulatory body, whether under the Companies Acts, the Articles or otherwise. You will be required to accept responsibility publicly and, where necessary, in writing, for
matters relating to the Company and the Group: 

  

	 	18.1	when required to do so by the Companies Acts, the Financial Services and Markets Act 2000 or other relevant legislation; 

  

	 	18.2	when required to do so by the rules or practice of the London Stock Exchange (as applicable); 

  

	 	18.3	when required to do so by the City Code on Takeovers and Mergers or the AIM Rules for Companies (as applicable); and 

  

	 	18.4	in any event, in the terms set out in the Statement of Adherence to Directors’ Responsibilities which will be printed in the Company’s Report and Accounts. 

 

	19.	Nothing in this letter is deemed to make you an employee of the Company. The Company signs this agreement by way of its acknowledgement of the terms upon which you have been engaged by the Employer to act as a
non-executive director of the Company. 

  

	20.	By signing this letter you consent to the Employer holding and processing information about you for legal, personnel, administrative and management purposes and in particular to the processing of any sensitive personal
data (as defined in the Data Protection Act 1998) including, as appropriate: 

  

	 	20.1	information about your physical or mental health or condition in order to monitor sick leave and take decisions as to your fitness for work; or 

 

	 	20.2	your racial or ethnic origin or religious or similar beliefs in order to monitor compliance with equal opportunities legislation; or 

 

	 	20.3	information relating to any criminal proceedings in which you have been involved for insurance purposes and in order to comply with legal requirements and obligations to third parties. 

You consent to the Employer making such information available to any Group Company, those who provide products or services to the Company (such as advisers
and payroll administrators), regulatory authorities, potential or future employers, governmental or quasi-governmental organisations and potential purchasers of the Company or the business in which you work. You also consent to the transfer of such
information to the Company’s business contacts outside the European Economic Area in order to further its business interests. 
  

	21.	Any reference in this agreement to:- 

	 	21.1	“the Board” shall mean the Board of Directors of the Company from time to time or any director or any committee of the Board duly appointed by it to act on its behalf; 

 

	 	21.2	“Code” means the City Code on Takeovers and Mergers issued from time to time by or on behalf of the Panel on Takeovers and Mergers in London; 

 

	 	21.3	“the Companies Acts” means every statute from time to time in force concerning companies insofar as it applies to the Company and/or any Group Company; 

 

	 	21.4	“Completion” shall mean the date upon which shares in the Company are admitted to trading on the Official List of the United Kingdom Listing Authority (“UKLA”) or in the AIM Market of the
London Stock Exchange Plc (“AlM”); 

  

	 	21.5	“Confidential Information” shall include information concerning the Company’s (and any Group Company’s): 

  

	 	(a)	finances, business transactions, research activities, dealings and affairs and prospective business transactions; 

  

	 	(b)	customers, including, without limitation, customer lists, customer identities and customer requirements; 

  

	 	(c)	existing and planned product lines, price lists and pricing structures (including, without limitation, discounts, special prices or special contract terms offered to or agreed with customers); 

 

	 	(d)	the technology or methodology associated with the concepts, products and services of any company in the Group; 

  

	 	(e)	business plans and sales and marketing information, plans and strategies; 

  

	 	(f)	computer systems, source codes and software; 

  

	 	(g)	the rights in all Intellectual Property; 

  

	 	(h)	directors, officers, employees and shareholders; and 

  

	 	(i)	the identities or lists of suppliers, licensors, licensees, agents, distributors or contractors (both current and those who were customers, suppliers, licensors, licensees, agents, distributors or contractors during the
previous two years) of any company in the Group; 

  

	 	21.6	“Group” means Summit Corporation plc any company or corporation which is a holding company for the time being of Summit Corporation plc, or a subsidiary for the time being of Summit Corporation plc or of any
such holding company (“holding company” and “subsidiary” having the meanings set out in section 1159, Companies Act 2006 as amended), or any company which is designated as being within the Group by the directors of the Board of
the Company; and 

  

	 	21.7	“Group Company” means a company within the Group (as defined above). 

	22.	The terms of this letter shall be governed by and construed in accordance with the laws of the State of Massachusetts save that all matters regarding the duties you owe to the Company in relation to your appointment as
a non-executive director shall be governed by and construed in accordance with English law. 

  

	23.	This agreement may be executed in two or more counterparts and the counterparts shall together constitute one agreement provided that each party has executed one or more counterparts. 

Kindly confirm your agreement to the terms set out above by signing the endorsement on the enclosed copy of this letter and returning the copy to me at the
above address. 
  

			
	EXECUTED and DELIVERED		)
	as a DEED by Summit Therapeutics Inc		)
	in accordance with its internal statutes		)
		
			/s/ Glyn Edwards
		
			Director
		
			/s/ Melissa Strange
		
			Secretary
		
	EXECUTED and DELIVERED		)
	as a DEED by Summit Corporation plc		)
	acting by:		)
		
			/s/ Glyn Edwards
		
			Director
		
			/s/ Melissa Strange
		
			Secretary
		
	EXECUTED and DELIVERED		)
	as a DEED by David Wurzer		)
		
	in the presence of:		
		
	Signature of witness		/s/ Daniel W. Wagner
		
	 Print name of witness
		Daniel W. Wagner
		
	 Print address of witness
		
			
		
	 Print occupation of witness
		Investor

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