Document:

Exhibit

Exhibit 10.4

Confidential Treatment Requested Under 17 C.F.R. §§ 200.80(b)(4) and 240-24b-2

Change Order Form # 30

Change order under Agreement dated: Fifth Amendment to Development and Clinical Supplies Agreement dated December 14, 2012

Between:  Radius Health, Inc and 3M

Project Name: For the development of Radius’ Abaloparatide compound delivered via 3M’s Microstructured Transdermal Delivery System

Change requested by: Radius
Name: Michele Gehrt
Company:  3M
Date:  24June2016

Description of change: 
Radius has requested that 3M complete stability testing in support of the process experiments (CO29), ready to coat (RTC), and Phase I clinical supplies of the sMTS abaloparatide (ABL) product.  In addition, they would like 3M to cross-in and validate (level 1) their UPLC impurity method and evaluate development of an in-vitro screening dissolution method.  Separate change orders will be issued to complete the process experiments and the manufacture of the clinical supplies.  The activities and deliverables in this Workplan are intended to support the further development of an optimized, sMTS abaloparatide product that demonstrates comparability (including pharmacokinetic bioequivalence or bioavailability) to the abaloparatide-SC injection product. The total estimated costs are $[*].
Scope:
3M will conduct the tasks necessary to complete the: 1) stability testing, 2) UPLC method validation and 3) evaluation of an in-vitro screening dissolution method.

Assumptions:
		
	•
	Process experiment stability for [*] only

		
	◦
	1, 3, 6 and 12 months at [*]; 12 month testing is optional

		
	◦
	2, 4, 8 and 12 weeks at [*]

		
	◦
	Test content and content uniformity

		
	◦
	Stability data to be used in the IND to establish retest dates for the clinical lot

		
	•
	RTC stability for 3 formulations

		
	o

	[*]

		
	o

	[*]

		
	o

	[*]

		
	o

	1, 2, 4 weeks at [*]

[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

Confidential Treatment Requested Under 17 C.F.R. §§ 200.80(b)(4) and 240-24b-2

Change Order Form # 30

		
	o

	Test purity, viscosity and content

		
	•
	Clinical Stability for all three formulations listed above

		
	o

	1, 3, 6 and 12 months at [*]; 12 month testing is optional

		
	o

	2, 4, 8 and 12 weeks at [*]

		
	o

	Testing includes: content, impurities, moisture, pouch integrity, pod integrity, packet ID, release from steel, release of patch from tabs, appearance, endotoxin   and microbials.

		
	•
	UPLC impurity method

		
	o

	Cross-in Radius’ method

		
	o

	Complete the method validation to Level 1 (sufficient for Phase I)

		
	•
	In-Vitro screening dissolution method

		
	o

	3M will spend 1 FTE month exploring the development of a screening dissolution method

Deliverables:
		
	•
	Presentations at JTT meetings outlining work as progressed.

		
	•
	Stability Data

		
	•
	UPLC Method Validation (Level 1)

Timing:
The required effort in hours, duration of the study in months, and estimated costs for the work plan are summarized in the table below.
	
				
	Task
	Estimated Effort (hours)
	Estimated
Duration (month)
	Estimated Direct Costs 
($)

	Process Experimental Stability, RTC Stability and Phase I Clinical Stability
UPLC Method
In-vitro screening dissolution method exploration
	1734
	12 

1
1
	$[*]

Total Estimated Costs:  $[*]

In all other respects, the terms and conditions of the Agreement remain in full force and effect.

Requested task, dates and costs are approved by:

2
[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

Confidential Treatment Requested Under 17 C.F.R. §§ 200.80(b)(4) and 240-24b-2

Change Order Form # 30

		
	Company: Radius Health, Inc
	Company:  3M

		
	Name: Gary Hattersley
	Name:  Michele Gehrt

		
	Signature: /s/ Gary Hattersley
	Signature: /s/ Michele Gehrt

		
	Position: CSO
	Position:  Commercialization Mgr

		
	Date (dd/mm/yy): 24 June 2016
	Date (dd/mm/yy): 24/06/16

3
[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.Exhibit

Exhibit 10.5

Confidential Treatment Requested Under 17 C.F.R. §§ 200.80(b)(4) and 240-24b-2

Change Order Form # 31

Change order under Agreement dated: Fifth Amendment to Development and Clinical Supplies Agreement dated December 14, 2012

Between:  Radius Health, Inc and 3M

Project Name: For the development of Radius’ Abaloparatide compound delivered via 3M’s Microstructured Transdermal Delivery System

Change requested by: Radius
Name: Michele Gehrt
Company:  3M
Date:  24June2016

Description of change: 
Radius has requested that 3M manufacture supplies of the sMTS abaloparatide (ABL) product for a Phase I Clinical Study.  The supplies include the following formulations:  [*].   Separate change orders will be issued to complete the process experiments and stability to support the clinical supply manufacture. The activities and deliverables in this Workplan are intended to support the further development of an optimized, sMTS abaloparatide product that demonstrates comparability (including pharmacokinetic bioequivalence or bioavailability) to the abaloparatide-SC injection product. The total estimated costs are $[*].
Scope:
3M will conduct the tasks necessary to manufacture 3 lots of supplies for a Phase I Clinical Study.  

Assumptions:
		
	•
	3M will utilize the new [*] for the commercial applicator to complete the work 

		
	•
	Radius will supply sufficient ABL to complete the work (6.3 g) unless the current inventory of lot 2AN1 is acceptable.

		
	•
	The target dose is 200 mcg/array.

		
	•
	Documentation will be completed to support the manufacture (batch records, specs, methods, and validation)

		
	•
	Input materials will be manufactured, cleared, assembled and [*].

		
	•
	3M will manufacture 425 arrays (supplies, release testing, stability testing and retains) for each of 3 formulations:

		
	◦
	[*]

		
	◦
	[*]

		
	◦
	[*]

		
	•
	3M will complete finished product testing and ship supplies to the clinical site.

		
	•
	3M will provide CMC documentation to Radius to support the IND.

[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

Confidential Treatment Requested Under 17 C.F.R. §§ 200.80(b)(4) and 240-24b-2

Change Order Form # 31

Deliverables:
		
	•
	Presentations at JTT meetings outlining work as progressed.

		
	•
	3 lots of clinical supplies 

		
	•
	CMC documentation for IND

Timing:
The required effort in hours, duration of the study in months, and estimated costs for the work plan are summarized in the table below.
	
				
	Task
	Estimated Effort (hours)
	Estimated
Duration (weeks)
	Estimated Direct Costs 
($)

	Phase I Clinical Supplies
	1842
	5
	$[*]

Total Estimated Costs Stage 2:  $[*]

In all other respects, the terms and conditions of the Agreement remain in full force and effect.

Requested task, dates and costs are approved by:

		
	Company: Radius Health, Inc
	Company:  3M

		
	Name: Gary Hattersley
	Name:  Michele Gehrt

		
	Signature: /s/ Gary Hattersley
	Signature: /s/ Michele Gehrt

		
	Position: CSO
	Position:  Commercialization Mgr

		
	Date (dd/mm/yy): 24 June 2016
	Date (dd/mm/yy): 24/06/16

[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.Exhibit

Exhibit 10.6

Confidential Treatment Requested Under 17 C.F.R. §§ 200.80(b)(4) and 240-24b-2

Change Order Form # 32

Change order under Agreement dated: Fifth Amendment to Development and Clinical Supplies Agreement dated December 14, 2012

Between:  Radius Health, Inc and 3M

Project Name: For the development of Radius’ Abaloparatide compound delivered via 3M’s Microstructured Transdermal Delivery System

Change requested by: Radius
Name: Michele Gehrt
Company:  3M
Date:  22July2016

Description of change: 
Radius has requested that 3M complete pH testing in support of the Phase I clinical supplies of the sMTS abaloparatide (ABL) product. A method will be developed to test the Ready to Coat (RTC). The activities and deliverables in this Workplan are intended to support the further development of an optimized, sMTS abaloparatide product that demonstrates comparability (including pharmacokinetic bioequivalence or bioavailability) to the abaloparatide-SC injection product. The total estimated costs are $[*].
Scope:
3M will conduct the tasks necessary to complete the development of a pH method for the RTC.

Assumptions:
		
	•
	RTC pH method development

		
	◦
	A probe will need to be purchased to test smaller volumes of formulation

Deliverables:
		
	•
	pH method for RTC

		
	•
	Presentations at JTT meetings outlining work as progressed.

Timing:
The required effort in hours, duration of the study in months, and estimated costs for the work plan are summarized in the table below.

	
				
	Task
	Estimated Effort (hours)
	Estimated
Duration (month)
	Estimated Direct Costs 
($)

	RTC pH Method Development
	55
	2
	$[*]

[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

Confidential Treatment Requested Under 17 C.F.R. §§ 200.80(b)(4) and 240-24b-2

Change Order Form # 32

Total Estimated Costs:  $[*]

In all other respects, the terms and conditions of the Agreement remain in full force and effect.

Requested task, dates and costs are approved by:

		
	Company: Radius Health, Inc
	Company:  3M

		
	Name: Ehab Hamed
	Name:  Michele Gehrt

		
	Signature: /s/ Ehab Hamed
	Signature: /s/ Michele Gehrt

		
	Position: Director
	Position:  Commercialization Mgr

		
	Date (dd/mm/yy): 22 Jul 2016
	Date (dd/mm/yy): 22/07/2016

2
[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

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