Document:

EX-10.1

 Exhibit 10.1 

CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT 

This Ninth Amended and Restated Investors’ Rights Agreement (this “Agreement”) is made as of June 29], 2020, by and
among Cardiva Medical, Inc., a Delaware corporation (the “Company”), and the Holders (as defined below) listed on Exhibit A hereto. This Agreement amends and restates the Seventh Amended and Restated Investors’ Rights
Agreement dated January 30, 2017 (the “Prior Rights Agreement”) entered into among the Company and certain of the Holders. Unless otherwise defined herein, capitalized terms used in this Agreement have the meanings ascribed to
them in Section 1. 
 RECITALS 

WHEREAS, certain of the Holders are parties to the Series 6 Preferred Stock Purchase Agreement of even date herewith (as may be amended
from time to time, the “Series 6 Purchase Agreement”), and it is a condition to the closing of the sale Series 6 Preferred Stock to certain of the Holders listed on such Schedule of Investors to the Series 6 Purchase Agreement that
certain Holders and the Company execute and deliver this Agreement; 
 WHEREAS, pursuant to the terms of the Prior Rights Agreement,
neither the Prior Rights Agreement nor any provision thereof may be amended, waived, discharged or terminated other than by written instrument referencing this Agreement and signed by the Company and the holders of at least a majority of the
Registrable Securities (as defined in the Prior Rights Agreement) (excluding any such shares that have been sold to the public or pursuant to Rule 144) (the “Required Parties”); and 

WHEREAS, the Company and each of the undersigned Holders, which include the Required Parties, desire to facilitate the investors’
rights arrangements set forth in this Agreement, amend and restate the Prior Rights Agreement as set forth herein and facilitate the sale and purchase of the shares of Series 6 Preferred pursuant to the Series 6 Purchase Agreement, by agreeing to
the terms and conditions set forth below. 
 NOW, THEREFORE: In consideration of the mutual promises and covenants set forth herein,
and other consideration, the receipt and adequacy of which is hereby acknowledged, the parties hereto agree as follows: 
 Section 1

 Definitions 

1.1 Certain Definitions. As used in this Agreement, the following terms shall have the meanings set forth below: 

(a) “Change of Control” means a transaction that qualifies as a “Liquidation” as defined in the Company’s
Amended and Restated Certificate of Incorporation. 
 (b) “Commission” shall mean the Securities and Exchange Commission or
any other federal agency at the time administering the Securities Act. 
 (c) “Common Stock” means the Common Stock of the
Company. 

 (d) “Exchange Act” shall mean the Securities Exchange Act of 1934, as
amended, or any similar successor federal statute and the rules and regulations thereunder, all as the same shall be in effect from time to time. 

(e) “Holder” shall mean: (1) any holder of Registrable Securities; (2) a purchaser of Common Stock upon exercise of
a Warrant (provided that such purchaser execute this Agreement upon exercise of such Warrant); and (3) any holder of Registrable Securities to whom the registration rights conferred by this Agreement have been duly and validly transferred in
accordance with Section 2.12 of this Agreement. 
 (f) “Indemnified Party” shall have the meaning
set forth in Section 2.6(c) hereto. 
 (g) “Indemnifying Party” shall have the meaning set forth
in Section 2.6(c) hereto. 
 (h) “Initial Public Offering” shall mean the closing of the
Company’s first firm commitment underwritten initial public offering pursuant to an effective registration statement filed under the Securities Act covering the offer and sale of the Company’s Common Stock. 

(i) “Initiating Holders” shall mean any Holder or Holders who in the aggregate hold not less than fifty percent (50%) of the
outstanding Registrable Securities. 
 (j) “New Securities” shall have the meaning set forth in
Section 4.1(a) hereto. 
 (k) “Preferred Holder” shall mean any holder of Preferred Stock. 

(l) “Preferred Stock” shall mean the Series 3 Preferred Stock, the Series 4 Preferred Stock, Series 5 Preferred Stock, and
Series 6 Preferred Stock. 
 (m) “Recapitalization” shall mean any stock dividend, stock split, combination of shares,
reorganization, recapitalization, reclassification or other similar event. 
 (n) “Registrable Securities” shall mean
(i) shares of Common Stock issued or issuable pursuant to the conversion of the Shares, (ii) any Common Stock issued as a dividend or other distribution with respect to or in exchange for or in replacement of the shares referenced in
(i) above, and (iii) for purposes of Section 2 only, Common Stock acquired upon exercise of a Warrant; provided, however, that Registrable Securities shall not include any shares of Common Stock described in
clause (i) or (ii) above that have previously been registered, that have been sold to the public either pursuant to a registration statement or Rule 144, or that have been sold in a private transaction in which the transferor’s rights
under this Agreement are not validly assigned in accordance with this Agreement. 
 (o) The terms “register,”
“registered” and “registration” shall refer to a registration effected by preparing and filing a registration statement in compliance with the Securities Act and applicable rules and regulations thereunder, and the
declaration or ordering of the effectiveness of such registration statement. 
 (p) “Registration Expenses” shall mean all
expenses incurred in effecting any registration pursuant to this Agreement, including, without limitation, all registration, qualification, and filing fees, printing expenses, escrow fees, fees and disbursements of counsel for the Company, fees and
disbursements of a single counsel representing all selling Holders, fees and disbursements of counsel representing any selling Holder holding not less than ten percent (10%) of the Registrable Securities (such amount not to exceed $25,000 with
respect to each such Holder), blue sky fees and expenses, and expenses of any regular or special audits incident to or required by any such registration, but shall not include Selling Expenses and the compensation of regular employees of the
Company. 

  
 -2- 

 (q) “Restricted Securities” shall mean any Registrable Securities required
to bear the first legend set forth in Section 2.8(c) hereof. 
 (r) “Right of First Refusal
Agreement” shall mean that certain Amended and Restated Right of First Refusal and Co-Sale Agreement, by and between the Company, the Investors and the Stockholders (in each case, as defined therein),
dated as of the date hereof, and as may be amended from time to time. 
 (s) “Rule 144” shall mean Rule 144 as promulgated
by the Commission under the Securities Act, as such Rule may be amended from time to time, or any similar successor rule that may be promulgated by the Commission. 

(t) “Rule 145” shall mean Rule 145 as promulgated by the Commission under the Securities Act, as such Rule may be amended
from time to time, or any similar successor rule that may be promulgated by the Commission 
 (u) “Rule 415” shall mean
Rule 415 as promulgated by the Commission under the Securities Act, as such Rule may be amended from time to time, or any similar successor rule that may be promulgated by the Commission. 

(v) “Securities Act” shall mean the Securities Act of 1933, as amended, or any similar successor federal statute and the
rules and regulations thereunder, all as the same shall be in effect from time to time. 
 (w) “Selling Expenses” shall
mean all underwriting discounts, selling commissions and stock transfer taxes applicable to the sale of Registrable Securities and fees and disbursements of counsel for any Holder, other than (i) Registration Expenses associated with a single
counsel representing all selling Holders and (ii) Registration Expenses associated with the separate counsel of such Holder, if such Holder holds not less than ten percent (10%) of the Registrable Securities (such amount not to exceed $25,000
with respect to such Holder). 
 (x) “Series 3 Preferred Stock” shall mean the Company’s Series 3 Preferred Stock.

 (y) “Series 4 Preferred Stock” shall mean the Company’s Series 4 Preferred Stock. 

(z) “Series 5 Preferred Stock” shall mean the Company’s Series 5 Preferred Stock. 

(aa) “Series 6 Preferred Stock” shall mean the Company’s Series 6 Preferred Stock. 

(bb) “Series 6 Purchase Agreement” shall have the meaning set forth in the Recitals hereto. 

(cc) “Shares” shall mean shares Preferred Stock. 

(dd) “Withdrawn Registration” shall mean a forfeited demand registration under Section 2.1 in
accordance with the terms and conditions of Section 2.4. 

  
 -3- 

 Section 2 

Registration Rights 

2.1 Requested Registration. 

(a) Request for Registration. Subject to the conditions set forth in this Section 2.1, if the Company shall
receive from Initiating Holders a written request signed by such Initiating Holders that the Company effect any registration with respect to all or a part of the Registrable Securities (such request shall state the number of shares of Registrable
Securities to be disposed of by such Initiating Holders), the Company will: 
 (i) promptly, and in any event within fifteen (15) days,
give written notice of the proposed registration to all other Holders; and 
 (ii) as soon as practicable, and in any event within ninety
(90) days of such request subject to any limitations set forth in this Section 2.1, file and use its commercially reasonable efforts to effect such registration (including, without limitation, filing post-effective
amendments, appropriate qualifications under applicable blue sky or other state securities laws, and appropriate compliance with the Securities Act) and to permit or facilitate the sale and distribution of all or such portion of such Registrable
Securities as are specified in such request, together with all or such portion of the Registrable Securities of any Holder or Holders joining in such request as are specified in a written request received by the Company within twenty (20) days
after such written notice from the Company is mailed or delivered. 
 (b) Limitations on Requested Registration. The Company shall
not be obligated to effect, or to take any action to effect, any such registration pursuant to this Section 2.1: 

(i) Prior to the earlier of (A) the three (3) year anniversary of the date of this Agreement or (B) one hundred eighty
(180) days following the effective date of the first registration statement filed by the Company covering an underwritten offering of any of its securities to the general public; 

(ii) If the Initiating Holders, together with the holders of any other securities of the Company entitled to inclusion in such registration
statement, propose to sell Registrable Securities and such other securities (if any) the aggregate proceeds of which (after deduction for underwriter’s discounts and expenses related to the issuance) are less than twenty million U.S. dollars
($20,000,000); 
 (iii) In any particular jurisdiction in which the Company would be required to execute a general consent to service of
process in effecting such registration, qualification, or compliance, unless the Company is already subject to service in such jurisdiction and except as may be required by the Securities Act; 

(iv) After the Company has initiated three (3) such registrations pursuant to this Section 2.1 (counting for
these purposes only (x) registrations that have been declared or ordered effective and pursuant to which securities have been sold, and (y) Withdrawn Registrations); 

(v) During the period starting with the date sixty (60) days prior to the Company’s good faith estimate of the date of filing of,
and ending on a date ninety (90) days after the effective date of, a Company-initiated registration (other than the Company’s initial registration which is addressed under Section 2.1(b)(i) above); provided that
the Company is actively employing in good faith all reasonable efforts to cause such registration statement to become effective; or 

  
 -4- 

 (vi) If the Initiating Holders propose to dispose of shares of Registrable Securities which
may be immediately registered on Form S-3 pursuant to a request made under Section 2.3 hereof. 

(c) Deferral. If (i) in the good faith judgment of the Board of Directors of the Company, the filing of a registration statement
covering the Registrable Securities would be detrimental to the Company and its shareholders and the Board of Directors of the Company concludes, as a result, that it is in the best interests of the Company to defer the filing of such registration
statement at such time, and (ii) the Company shall furnish to such Holders a certificate signed by the President of the Company stating that in the good faith judgment of the Board of Directors of the Company, it would be detrimental to the
Company and its shareholders for such registration statement to be filed in the near future and that it is, therefore, in the best interests of the Company to defer the filing of such registration statement, then (in addition to the limitations set
forth in Section 2.1(b)(v) above) the Company shall have the right to defer such filing for a period of not more than sixty (60) days after receipt of the request of the Initiating Holders, and, provided further, that
the Company shall not defer its obligation in this manner more than twice in any twelve (12) month period. 
 (d) Underwriting.
If the Initiating Holders intend to distribute the Registrable Securities covered by their request pursuant to this Section 2.1 by means of an underwriting, they shall so advise the Company as a part of their request made
pursuant to this Section 2.1 and the Company shall include such information in the written notice given pursuant to Section 2.1(a)(i). In such event, the right of any Holder to include all or any
portion of its Registrable Securities in such registration pursuant to this Section 2.1 shall be conditioned upon such Holder’s participation in such an underwriting and the inclusion of such Holder’s Registrable
Securities to the extent provided herein. If the Company shall request inclusion in any registration pursuant to Section 2.1 of securities being sold for its own account, or if other persons shall request inclusion in any
registration pursuant to Section 2.1, the Initiating Holders shall, on behalf of all Holders, offer to include such securities in the underwriting and such offer shall be conditioned upon the participation of the Company or
such other persons in such underwriting and the inclusion of the Company’s and such person’s other securities of the Company and their acceptance of the further applicable provisions of this Section 2 (including
Section 2.10). The Company shall select the underwriters (subject to the consent of the Initiating Holders holding a majority of Registrable Securities to be included in such underwriting, which such approval shall not be
unreasonably withheld or delayed) and (together with all Holders proposing to distribute their securities through such underwriting) enter into an underwriting agreement in customary form with the representative of the underwriter or underwriters
selected for such underwriting. 
 Notwithstanding any other provision of this Section 2.1, if the underwriters
advise the Initiating Holders in writing that marketing factors require a limitation on the number of shares to be underwritten, the number of Registrable Securities that may be so included shall be allocated as follows: (i) first, among all
Holders requesting to include Registrable Securities in such registration statement based on the pro rata percentage of Registrable Securities held by such Holders; and (ii) second, to the Company, which the Company may allocate, at its
discretion, for its own account, or for the account of other holders or employees of the Company; provided, however, that the number of shares of Registrable Securities to be included in such underwriting shall not be reduced unless all other
securities are first entirely excluded from the underwriting. 
 If a person who has requested inclusion in such registration as provided
above does not agree to the terms of any such underwriting, such person shall be excluded therefrom by written notice from the Company, the underwriter or the Initiating Holders. The securities so excluded shall also be withdrawn from registration.
Any Registrable Securities or other securities excluded or withdrawn from such underwriting shall also be withdrawn from such registration. If shares are so withdrawn or excluded from 

  
 -5- 

 
the registration and if the number of shares to be included in such registration was previously reduced as a result of marketing factors pursuant to this Section 2.1(d),
then the Company shall then offer to all Holders who have retained rights to include securities in the registration the right to include additional Registrable Securities in the registration in an aggregate amount equal to the number of shares so
withdrawn or excluded, with such shares to be allocated pro rata among such Holders requesting additional inclusion, as set forth above. 

2.2 Company Registration. 

(a) Company Registration. If the Company shall determine to register any of its securities either for its own account or the account of
a security holder or holders, other than a registration pursuant to Section 2.1 or 2.3, a registration relating solely to employee benefit plans, a registration relating to the offer and sale of debt securities, a
registration relating to a corporate reorganization or other Rule 145 transaction, or a registration on any registration form that does not permit secondary sales, the Company will: 

(i) promptly, and in any event within fifteen (15) days, give written notice of the proposed registration to all Holders; and 

(ii) use its commercially reasonable efforts to include in such registration (and any related qualification under blue sky laws or other
compliance), except as set forth in Section 2.2(b) below, and in any underwriting involved therein, all of such Registrable Securities as are specified in a written request or requests made by any Holder or Holders received
by the Company within ten (10) days after such written notice from the Company is mailed or delivered. Such written request may specify all or a part of a Holder’s Registrable Securities. 

(b) Underwriting. If the registration of which the Company gives notice is for a registered public offering involving an underwriting,
the Company shall so advise the Holders as a part of the written notice given pursuant to Section 2.2(a)(i). In such event, the right of any Holder to registration pursuant to this Section 2.2
shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their securities
through such underwriting shall (together with the Company and the other holders of securities of the Company with registration rights to participate therein distributing their securities through such underwriting) enter into an underwriting
agreement in customary form with the representative of the underwriter or underwriters selected by the Company. 
 Notwithstanding any other
provision of this Section 2.2, if the underwriters advise the Company that marketing factors require a limitation on the number of shares to be underwritten, the underwriters may (subject to the limitations set forth below)
exclude all Registrable Securities from, or limit the number of Registrable Securities to be included in, the registration and underwriting; provided that the foregoing limitation may only be applied after the Company has excluded from such
registration all securities held by holders other than holders of Registrable Securities that the Company intends to include in such registration; and provided further following the Company’s Initial Public Offering, the number of Registrable
Securities to be included in any such registration shall not be reduced below twenty percent (20%) of the number of shares to be underwritten. The Company shall so advise all holders of securities requesting registration, and the number of shares of
securities that are entitled to be included in the registration and underwriting shall be allocated, as follows: (i) first, to the Company for securities being sold for its own account and (ii) second, to the Holders requesting to include
Registrable Securities in such registration statement based on the pro rata percentage of Registrable Securities held by such Holders. 

  
 -6- 

 If a person who has requested inclusion in such registration as provided above does not
agree to the terms of any such underwriting, such person shall also be excluded therefrom by written notice from the Company or the underwriter. The Registrable Securities or other securities so excluded shall also be withdrawn from such
registration. Any Registrable Securities or other securities excluded or withdrawn from such underwriting shall be withdrawn from such registration. 

If shares are so withdrawn or excluded from the registration and if the number of shares of Registrable Securities to be included in such
registration was previously reduced as a result of marketing factors, the Company shall use its commercially reasonable efforts to offer to all persons who have retained the right to include securities in such registration the right to include
additional securities in the next registration in an aggregate amount equal to the number of shares so withdrawn or excluded, with such shares to be allocated pro rata among the persons requesting additional inclusion in accordance with
Section 2.2 hereof. 
 (c) Right to Terminate Registration. The Company shall have the right to terminate
or withdraw any registration initiated by it under this Section 2.2 prior to the effectiveness of such registration whether or not any Holder has elected to include securities in such registration. The Registration Expenses
of such withdrawn registration shall be borne by the Company in accordance with Section 2.4 hereof. 
 2.3
Registration on Form S-3. 
 (a) Request for Form
S-3 Registration. The Company shall use its best efforts to qualify for registration on Form S-3 or any comparable or similar short form registration statement or
successor form or forms (“Form S-3”) after its Initial Public Offering. After the Company has qualified for the use of Form S-3, in addition to the
rights contained in the foregoing provisions of this Section 2 and subject to the conditions set forth in this Section 2.3, if the Company shall receive from Holders of not less than ten percent
(10%) of the Registrable Securities a written request that the Company effect any registration on Form S-3 with respect to all or part of the Registrable Securities (such request shall state the number of
shares of Registrable Securities to be disposed of and the intended methods of disposition of such shares by such Holders), the Company will take all such action with respect to such Registrable Securities as required by
Section 2.1(a)(i) and (ii). 
 (b) Limitations on Form S-3
Registration. The Company shall not be obligated to effect, or take any action to effect, any such registration pursuant to this Section 2.3: 

(i) In the circumstances described in either Sections 2.1(b)(i), 2.1(b)(iii) or 2.1(b)(v); 

(ii) If the Holders, together with the holders of any other securities of the Company entitled to inclusion in such registration, propose to
sell Registrable Securities and such other securities (if any) on Form S-3 at an aggregate price to the public of less than one million U.S. dollars ($1,000,000); or 

(iii) If, in a given six (6) month period, the Company has effected one (1) such registration in such period. 

(c) Deferral. If (i) in the good faith judgment of the Board of Directors of the Company, the filing of a registration statement
on Form S-3 covering the Registrable Securities would be detrimental to the Company and its shareholders and the Board of Directors of the Company concludes, as a result, that it is in the best interests of
the Company to defer the filing of such registration statement on Form S-3 at such time, and (ii) the Company shall furnish to such Holders a certificate signed by the

  
 -7- 

 
President of the Company stating that in the good faith judgment of the Board of Directors of the Company, it would be detrimental to the Company and its shareholders for such registration
statement to be filed in the near future and that it is, therefore, in the best interests of the Company to defer the filing of such registration statement on Form S-3, then (in addition to the limitations set
forth in Section 2.1(b)(v) above) the Company shall have the right to defer such filing for a period of not more than ninety (90) days after receipt of the request of the Initiating Holders, and, provided further, that
the Company shall not defer its obligation in this manner more than once in any twelve (12) month period. 
 (d) Underwriting.
If the Holders of Registrable Securities requesting registration under this Section 2.3 intend to distribute the Registrable Securities covered by their request by means of an underwriting, the provisions of Sections
2.1(e) shall apply to such registration. Notwithstanding anything contained herein to the contrary, registrations effected pursuant to this Section 2.3 shall not be counted as requests for registration or registrations
effected pursuant to Section 2.1. 
 2.4 Expenses of Registration. All Registration Expenses incurred in
connection with registrations pursuant to Sections 2.1, 2.2 and 2.3 hereof shall be borne by the Company; provided, however, that the Company shall not be required to pay for any expenses of any registration proceeding begun
pursuant to Sections 2.1 and 2.3 if (i) the withdrawal of such registration proceeding is based upon material adverse information concerning the Company which was made known to the Holders requesting registration by the Company at
the time of such request or (ii) the registration request is subsequently withdrawn at the request of the Holders of a majority of the Registrable Securities to be registered or because a sufficient number of Holders shall have withdrawn so
that the minimum offering conditions set forth in Sections 2.1 and 2.3 are no longer satisfied (in which case all participating Holders shall bear such expenses pro rata among each other based on the number of Registrable Securities requested to be
so registered), unless the Holders of a majority of the Registrable Securities agree to forfeit their right to a demand registration pursuant to Section 2.1 (in which case such Registration Expenses shall be borne by the
Company). All Selling Expenses relating to securities registered on behalf of the Holders shall be borne by the holders of securities included in such registration pro rata on the basis of the number of Registrable Securities registered by the
applicable Holders. 
 2.5 Registration Procedures. In the case of each registration effected by the Company pursuant to
Section 2, the Company will keep each Holder advised in writing as to the initiation of each registration and as to the completion thereof. At its expense, the Company will use its commercially reasonable efforts to: 

(a) Keep such registration effective for a period ending on the earlier of the date which is ninety (90) days from the effective date of
the registration statement or such time as the Holder or Holders have completed the distribution described in the registration statement relating thereto; provided, however, that such ninety (90) day period shall be extended for a period of
time equal to the period the Holder agrees to refrain from selling any securities included in such registration at the request of the Company or an underwriter of Common Stock of the Company; 

(b) Prepare and file with the Commission such amendments and supplements to such registration statement and the prospectus used in connection
with such registration statement as may be necessary to comply with the provisions of the Securities Act with respect to the disposition of all securities covered by such registration statement for the period set forth in subsection (a) above;

 (c) Furnish such number of prospectuses, including any preliminary prospectuses, and other documents incident thereto, including any
amendment of or supplement to the prospectus, as a Holder from time to time may reasonably request; 

  
 -8- 

 (d) Use its reasonable best efforts to register and qualify the securities covered by such
registration statement under such other securities or Blue Sky laws of such jurisdiction as shall be reasonably requested by the Holders; provided, that the Company shall not be required in connection therewith or as a condition thereto to qualify
to do business or to file a general consent to service of process in any such states or jurisdictions; 
 (e) Notify each seller of
Registrable Securities covered by such registration statement at any time when a prospectus relating thereto is required to be delivered under the Securities Act of the happening of any event as a result of which the prospectus included in such
registration statement, as then in effect, includes an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading or incomplete in light of the
circumstances then existing, and following such notification promptly prepare and furnish to such seller a reasonable number of copies of a supplement to or an amendment of such prospectus as may be necessary so that, as thereafter delivered to the
purchasers of such shares, such prospectus shall not include an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading or incomplete in light of
the circumstances then existing; 
 (f) Provide a transfer agent and registrar for all Registrable Securities registered pursuant to such
registration statement and a CUSIP number for all such Registrable Securities, in each case not later than the effective date of such registration; 

(g) Cause all such Registrable Securities registered pursuant hereunder to be listed on each securities exchange or nationally recognized
quotation system on which similar securities issued by the Company are then listed or quoted; 
 (h) In connection with any underwritten
offering pursuant to a registration statement filed pursuant to Section 2.1 and, if applicable, Section 2.3 hereof, enter into an underwriting agreement in form reasonably necessary to effect the
offer and sale of Common Stock, provided such underwriting agreement contains reasonable and customary provisions and that the Holders participating in such underwriting are presented an opportunity to review and comment on such underwriting
agreement, and provided further, that each Holder participating in such underwriting shall also enter into and perform its obligations under such an agreement; and 

(i) Furnish, at the request of the Holders of at least five hundred thousand (500,000) shares of Registrable Securities (as adjusted for stock
splits, stock dividends, reverse stock splits, stock combinations or other similar capitalization changes) requesting registration of Registrable Securities pursuant to this Section 2, on the date that such Registrable
Securities are delivered to the underwriters for sale in connection with a registration pursuant to this Section 2, if such securities are being sold through underwriters, (i) an opinion, dated such date, of the
counsel representing the Company for the purposes of such registration, in form and substance as is customarily given to underwriters in an underwritten public offering, addressed to the underwriters, if any, and to the Holders requesting
registration of Registrable Securities and (ii) a letter dated such date, from the independent certified public accountants of the Company, in form and substance as is customarily given by independent certified public accountants to
underwriters in an underwritten public offering, addressed to the underwriters, if any, and to the Holders requesting registration of Registrable Securities. 

2.6 Indemnification. In the event that any Registrable Securities are included in a registration statement pursuant to Sections
2.1, 2.2 or 2.3 hereof: 
 (a) To the extent permitted by law, the Company will indemnify and hold harmless each Holder,
each of its officers, directors and partners, legal counsel, and accountants and each person 

  
 -9- 

 
controlling such Holder within the meaning of Section 15 of the Securities Act, with respect to which registration, qualification, or compliance has been effected pursuant to this
Section 2, and each underwriter, if any, and each person who controls within the meaning of Section 15 of the Securities Act any underwriter, against all expenses, claims, losses, damages, and liabilities (or actions,
proceedings, or settlements in respect thereof) arising out of or based on: (i) any untrue statement (or alleged untrue statement) of a material fact contained or incorporated by reference in any prospectus, offering circular, or other document
(including any related registration statement, notification, or the like) incident to any such registration, qualification, or compliance, (ii) any omission (or alleged omission) to state therein a material fact required to be stated therein or
necessary to make the statements therein not misleading, or (iii) any violation (or alleged violation) by the Company of the Securities Act, the Exchange Act, any state securities laws or any rule or regulation thereunder applicable to the
Company and relating to action or inaction required of the Company in connection with any offering covered by such registration, qualification, or compliance (a “Violation”), and the Company will reimburse each such Holder, each of
its officers, directors, partners, legal counsel, and accountants and each person controlling such Holder, each such underwriter, and each person who controls any such underwriter, for any legal and any other expenses reasonably incurred in
connection with investigating and defending or settling any such claim, loss, damage, liability, or action; provided that the Company will not be liable in any such case to the extent that any such claim, loss, damage, liability, or action arises
out of or is based on any untrue statement or omission based directly upon written information furnished to the Company by such Holder, any of such Holder’s officers, directors, partners, legal counsel or accountants, any person controlling
such Holder, such underwriter or any person who controls any such underwriter and stated to be specifically for use therein; and provided, further that, the indemnity agreement contained in this Section 2.6(a) shall not
apply to amounts paid in settlement of any such loss, claim, damage, liability, or action if such settlement is effected without the consent of the Company (which consent shall not be unreasonably withheld or delayed). 

(b) To the extent permitted by law, each Holder will, if Registrable Securities held by such Holder are included in the securities as to which
such registration, qualification, or compliance is being effected, indemnify and hold harmless the Company, each of its directors, officers, partners, legal counsel, and accountants and each underwriter, if any, of the Company’s securities
covered by such a registration statement, each person who controls the Company or such underwriter within the meaning of Section 15 of the Securities Act, each other such other Holder, and each of their officers, directors, and partners, and
each person controlling such other Holder, against all claims, losses, damages and liabilities (or actions in respect thereof) arising out of or based on: (i) any untrue statement (or alleged untrue statement) of a material fact contained or
incorporated by reference in any such registration statement, prospectus, offering circular, or other document, or (ii) any omission (or alleged omission) to state therein a material fact required to be stated therein or necessary to make the
statements therein not misleading, and will reimburse the Company and such Holders, directors, officers, partners, legal counsel, and accountants, persons, underwriters, or control persons for any legal or any other expenses reasonably incurred in
connection with investigating or defending any such claim, loss, damage, liability, or action, in each case to the extent, but only to the extent, that such untrue statement (or alleged untrue statement) or omission (or alleged omission) is made in
such registration statement, prospectus, offering circular, or other document in reliance upon and in conformity with written information furnished to the Company by such Holder and stated to be specifically for use therein; provided, however, that
the obligations of such Holder hereunder shall not apply to amounts paid in settlement of any such claims, losses, damages, or liabilities (or actions in respect thereof) if such settlement is effected without the consent of such Holder (which
consent shall not be unreasonably withheld or delayed); and provided that in no event shall any indemnity under this Section 2.6 exceed the net proceeds from the offering received by such Holder. 

(c) Each party entitled to indemnification under this Section 2.6 (the “Indemnified Party”) shall
give notice to the party required to provide indemnification (the “Indemnifying Party”) promptly after such Indemnified Party has actual knowledge of any claim as to which indemnity may be

  
 -10- 

 
sought, and shall permit the Indemnifying Party to assume the defense of such claim or any litigation resulting therefrom; provided that counsel for the Indemnifying Party, who shall
conduct the defense of such claim or any litigation resulting therefrom, shall be approved by the Indemnified Party (whose approval shall not be unreasonably withheld or delayed), and the Indemnified Party may participate in such defense at such
party’s expense; and provided further that the failure of any Indemnified Party to give notice as provided herein shall not relieve the Indemnifying Party of its obligations under this Section 2.6, to the
extent such failure is not prejudicial. No Indemnifying Party, in the defense of any such claim or litigation, shall, except with the consent of each Indemnified Party, consent to entry of any judgment or enter into any settlement that does not
include as an unconditional term thereof the giving by the claimant or plaintiff to such Indemnified Party of a release from all liability in respect to such claim or litigation. Each Indemnified Party shall furnish such information regarding itself
or the claim in question as an Indemnifying Party may reasonably request in writing and as shall be reasonably required in connection with defense of such claim and litigation resulting therefrom. 

(d) If the indemnification provided for in this Section 2.6 is held by a court of competent jurisdiction to be
unavailable to an Indemnified Party with respect to any loss, liability, claim, damage, or expense referred to herein, then the Indemnifying Party, in lieu of indemnifying such Indemnified Party hereunder, shall contribute to the amount paid or
payable by such Indemnified Party as a result of such loss, liability, claim, damage, or expense in such proportion as is appropriate to reflect the relative fault of the Indemnifying Party on the one hand and of the Indemnified Party on the other
in connection with the statements or omissions that resulted in such loss, liability, claim, damage, or expense as well as any other relevant equitable considerations. The relative fault of the Indemnifying Party and of the Indemnified Party shall
be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission to state a material fact relates to information supplied by the Indemnifying Party or by the Indemnified Party and
the parties’ relative intent, knowledge, access to information, and opportunity to correct or prevent such statement or omission. The parties hereto agree that it would not be just and equitable if contribution pursuant to this
Section 2.6(d) were determined by pro rata allocation or by any other method of allocation that does not take account of the equitable considerations referred to in the immediately preceding sentence. Notwithstanding
the provision of this Section 2.6(d), an Indemnifying Party that is a selling Holder of Registrable Securities shall not be required to contribute any amount in excess of the amount by which the total price at which the
Registrable Securities sold by such Indemnifying Party exceeds the amount of any damages that such Indemnifying Party has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission. No person
found guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) by a court of competent jurisdiction shall be entitled to contribution from any Person who was not found guilty of such fraudulent
misrepresentation by a court of competent jurisdiction. 
 (e) Notwithstanding the foregoing, to the extent that the provisions on
indemnification and contribution contained in the underwriting agreement entered into in connection with the underwritten public offering are in conflict with the foregoing provisions, the provisions in the underwriting agreement shall control. 

2.7 Information by Holder. Each Holder of Registrable Securities shall furnish to the Company such information regarding such Holder
and the distribution proposed by such Holder as the Company may reasonably request in writing and as shall be reasonably required in connection with any registration, qualification, or compliance referred to in this
Section 2. 
 2.8 Restrictions on Transfer. 

(a) Each holder of Company securities party to this Agreement (each, a “Securityholder”), by acceptance thereof agrees to
comply in all respects with the provisions of this 

  
 -11- 

 
Section 2.8. Each Securityholder agrees not to make any sale, assignment, transfer, pledge or other disposition of all or any Company securities, or any beneficial
interest therein, unless and until (x) the transferee thereof has agreed in writing for the benefit of the Company to take and hold such securities subject to, and to be bound by, the terms and conditions set forth in this Agreement, including,
without limitation, this Section 2.8 and Section 2.10, except for transfers permitted under Section 2.8(b), and (y): 

(i) There is then in effect a registration statement under the Securities Act covering such proposed disposition and such disposition is made
in accordance with such registration statement; or 
 (ii) Such Securityholder shall have given prior written notice to the Company of such
Securityholder’ s intention to make such disposition and shall have furnished the Company with a detailed description of the manner and circumstances of the proposed disposition, and, such Securityholder shall have furnished the Company, at its
expense, with (i) an opinion of counsel, reasonably satisfactory to the Company, to the effect that such disposition will not require registration of such securities under the Securities Act or (ii) a “no action” letter from the
Commission to the effect that the transfer of such securities without registration will not result in a recommendation by the staff of the Commission that action be taken with respect thereto, whereupon the Securityholder shall be entitled to
transfer such securities in accordance with the terms of the notice delivered by the Securityholder to the Company. 
 (b) Permitted
transfers include (i) a transfer not involving a change in beneficial ownership, or (ii) in transactions involving the distribution of securities by any Securityholder to (x) a parent, subsidiary or other affiliate of the
Securityholder that is a corporation, or (y) any of its partners, members or other equity owners, or retired partners, retired members or other equity owners, or to the estate of any of its partners, members or other equity owners or retired
partners, retired members or other equity owners, (iii) transfers without consideration in connection with a liquidation, dissolution or winding up of a Securityholder, or (iv) transfers in compliance with Rule 144, as long as the Company
is furnished with satisfactory evidence of compliance with such Rule; provided, in each case, that the Securityholder thereof shall give written notice to the Company of such Securityholder’s intention to effect such disposition and shall have
furnished the Company with a detailed description of the manner and circumstances of the proposed disposition. 
 (c) Each certificate
representing securities held by a Securityholder shall (unless otherwise permitted by the provisions of this Agreement) be stamped or otherwise imprinted with a legend substantially similar to the following (in addition to any legend required under
applicable state securities laws): 
 THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED (THE “ACT”), OR UNDER THE SECURITIES LAWS OF CERTAIN STATES. THESE SECURITIES MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED EXCEPT AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS
PURSUANT TO REGISTRATION OR AN EXEMPTION THEREFROM. THE ISSUER OF THESE SECURITIES MAY REQUIRE AN OPINION OF COUNSEL SATISFACTORY TO THE ISSUER THAT SUCH OFFER, SALE OR TRANSFER, PLEDGE OR HYPOTHECATION OTHERWISE COMPLIES WITH THE ACT AND ANY
APPLICABLE STATE SECURITIES LAWS. 
 THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO (1) RESTRICTIONS ON TRANSFERABILITY AND
RESALE, INCLUDING A LOCK-UP PERIOD IN THE EVENT OF A PUBLIC OFFERING, AS SET FORTH IN AN INVESTORS’ RIGHTS AGREEMENT, AND (2) VOTING RESTRICTIONS AS SET FORTH IN A VOTING AGREEMENT AMONG THE COMPANY
AND THE ORIGINAL HOLDERS OF THESE SHARES, COPIES OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF THE COMPANY. 

  
 -12- 

 Each Securityholder consents to the Company making a notation on its records and g1vmg
instructions to any transfer agent of such Securityholder’s securities in order to implement the restrictions on transfer established in this Section 2.8. 

(d) The first legend referring to federal and state securities laws identified in Section 2.8(c) hereof stamped on a
certificate evidencing the securities held by Securityholders and the stock transfer instructions and record notations with respect to such securities shall be removed and the Company shall issue a certificate without such legend to the holder of
such securities if (i) such securities are registered under the Securities Act, or (ii) such holder provides the Company with an opinion of counsel reasonably acceptable to the Company to the effect that a public sale or transfer of such
securities may be made without registration under the Securities Act, or (iii) such holder provides the Company with reasonable assurances, which may, at the option of the Company, include an opinion of counsel satisfactory to the Company, that
such securities can be sold pursuant to Rule 144 under the Securities Act. 
 2.9 Rule 144 Reporting. With a view to making available
the benefits of certain rules and regulations of the Commission that may permit the sale of the Restricted Securities to the public without registration, the Company agrees to use its reasonable best efforts to: 

(a) Make and keep public information regarding the Company available as those terms are understood and defined in Rule 144 under the Securities
Act, at all times from and after ninety (90) days following the effective date of the first registration under the Securities Act filed by the Company for an offering of its securities to the general public; 

(b) File with the Commission in a timely manner all reports and other documents required of the Company under the Securities Act and the
Exchange Act at any time after it has become subject to such reporting requirements; and 
 (c) So long as a Holder owns any Restricted
Securities, furnish to the Holder forthwith upon written request a written statement by the Company as to its compliance with the reporting requirements of Rule 144 (at any time from and after ninety (90) days following the effective date of
the first registration statement filed by the Company for an offering of its securities to the general public), and of the Securities Act and the Exchange Act (at any time after it has become subject to such reporting requirements), a copy of the
most recent annual or quarterly report of the Company, and such other reports and documents so filed as a Holder may reasonably request in availing itself of any rule or regulation of the Commission allowing a Holder to sell any such securities
without registration. 
 2.10 Market Stand-Off Agreement. Each Securityholder hereby agrees
that such Securityholder shall not sell or otherwise transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale, of any Common Stock (or other
securities) of the Company held by such Securityholder (other than those included in the registration), during the period beginning on the date the Company files a registration statement to effect the Company’s Initial Public Offering and
ending one hundred eighty (180) days following the effective date of the Company’s Initial Public Offering filed under the Securities Act (or such longer period of time as may be required to accommodate regulatory restrictions on
(x) the publication or other distribution of research reports and (y) analyst recommendations and opinions, including, but not limited to, the restrictions contained in FINRA Rule 2711 (f)(4) or NYSE Rule 472(f)(4), as applicable, (or any
successor rules or 

  
 -13- 

 
amendments thereto)) (the “Market Standoff Period”); provided, however, that such agreement shall only be applicable if all officers, directors and holders of at least one
percent (1%) of the outstanding capital stock of the Company are similarly bound; and provided, further, if the Company or the underwriters shall release any Registrable Securities or any other securities (the “Released Securities”)
from the requirements of this Section 2.10 before the end of the period set by the Company or the underwriters, then the Registrable Securities of each Holder shall be released from the provisions of this
Section 2.10 in the same proportion as the Released Securities bear to the total number of securities held by such Holder which were subject to this Section 2.10. The obligations described in this
Section 2.10 shall not apply to a registration relating solely to employee benefit plans on Form S-1 or Form S-8 or similar forms that may be
promulgated in the future, or a registration relating solely to a Rule 145 transaction. The Company may impose stop-transfer instructions and may stamp each such certificate with the second legend set forth in
Section 2.8(c) hereof with respect to the shares of Common Stock (or other securities) subject to the foregoing restriction until the end of the Market Standoff Period. Each Securityholder agrees to execute a market
standoff agreement with said underwriters in customary form consistent with the provisions of this Section 2.10. 

2.11 Delay of Registration. No Holder shall have any right to take any action to restrain, enjoin, or otherwise delay any registration
as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 

2.12 Transfer or Assignment of Registration Rights. The rights to cause the Company to register securities granted to a Holder by the
Company under this Section 2 may be transferred or assigned by a Holder only to a transferee or assignee of not less than two hundred thousand (200,000) shares of Registrable Securities (as presently constituted and subject
to subsequent adjustments for stock splits, stock dividends, reverse stock splits, and the like); provided that (i) such transfer or assignment of Registrable Securities is effected in accordance with the terms of
Section 2.8 hereof, the Right of First Refusal and Co-Sale Agreement, and applicable securities laws, (ii) the Company is given prompt written notice of such transfer or
assignment, stating the name and address of the transferee or assignee and identifying the securities with respect to which such registration rights have been transferred or assigned and (iii) the transferee or assignee of such rights assumes
in writing the obligations of such Holder under this Agreement, including without limitation the obligations set forth in Section 2.10. 

2.13 Limitations on Subsequent Registration Rights. From and after the date of this Agreement, the Company shall not, without the prior
written consent of Holders of at least a majority of the Registrable Securities, enter into any agreement with any holder or prospective holder of any securities of the Company giving such holder or prospective holder any registration rights the
terms of which are senior to the registration rights granted to the Holders hereunder. 
 2.14 Termination of Registration Rights.
The right of any Holder to request registration or inclusion in any registration pursuant to Section 2.1, 2.2 or 2.3 shall terminate on the earliest of (i) such date, on or after the closing of the
Company’s Initial Public Offering, on which all shares of Registrable Securities held or entitled to be held upon conversion by such Holder may immediately be sold pursuant Rule 144 under the Securities Act during any ninety (90)-day period, (ii) four (4) years after the closing of the Company’s Initial Public Offering or (iii) nine (9) years after the closing of the Company’s Initial Public Offering for
“affiliates” (as such term is defined in Rule 144 under the Securities Act). 

  
 -14- 

 Section 3 

Covenants of the Company 

The Company hereby covenants and agrees, as follows: 

3.1 Information Rights. 

(a) Basic Financial Information. The Company will furnish the following reports to each Preferred Holder who owns at least one million
(1,000,000) shares of Preferred Stock (as presently constituted and subject to subsequent adjustments for stock splits, stock dividends, reverse stock splits, and the like) (a “Major Investor”); provided that all shares of Preferred
Stock held or acquired by “affiliates” (as such term is defined in Rule 144 under the Securities Act) of a Preferred Holder shall be aggregated together with the shares of Preferred Stock held by such Preferred Holder for the purpose of
determining the availability of any rights under this Section 3: 
 (i) As soon as practicable after the end of each fiscal year of the
Company, and in any event within ninety (90) days after the end of each fiscal year of the Company, an audited consolidated balance sheet of the Company and its subsidiaries, if any, as at the end of such fiscal year, and audited consolidated
statements of income and cash flows of the Company and its subsidiaries, if any, for such year, prepared in accordance with U.S. generally accepted accounting principles consistently applied, certified by independent public accountants of recognized
national standing selected by the Board of Directors of the Company. 
 (ii) As soon as practicable after the end of the first, second and
third quarterly accounting periods in each fiscal year of the Company, and in any event within thirty (30) days after the end of the first, second, and third quarterly accounting periods in each fiscal year of the Company, an unaudited
consolidated balance sheet of the Company and its subsidiaries, if any, as of the end of each such quarterly period, and unaudited consolidated statements of income and cash flows of the Company and its subsidiaries, if any, for such period,
prepared in accordance with U.S. generally accepted accounting principles consistently applied, subject to changes resulting from normal year-end audit adjustments. 

(iii) A soon as practicable after the end of each calendar month (excluding those months wherein the Major Investor will receive financial
information pursuant to Sections 3.1(a)(i) and (ii) above) in each fiscal year of the Company, and in any event within ten (10) business days after the end of each calendar month in each fiscal year of the Company, an
unaudited consolidated balance sheet of the Company and its subsidiaries, if any, as of the end of such calendar month, and unaudited consolidated statements of income and cash flows of the Company and its subsidiaries, if any, for such calendar
month, prepared in accordance with U.S. generally accepted accounting principles consistently applied, subject to changes resulting from normal year-end audit adjustments. 

(b) Annual Budget. The Company shall furnish the annual budget for a particular fiscal year to each Major Investor on the earlier of
(i) thirty (30) days prior to the beginning of a fiscal year if such annual budget has been approved by the Board of Directors or (ii) within fifteen (15) days of the approval of such annual budget by the Company’s Board of
Directors. 
 (c) Notwithstanding anything else in this Subsection 3.1 to the contrary, the Company may cease providing the information set
forth in this Subsection 3.1 during the period starting with the date sixty (60) days before the Company’s good-faith estimate of the date of filing of a registration statement if it reasonably concludes it must do so to comply with the
SEC rules applicable to such registration statement and related offering; provided that the Company’s covenants under this Subsection 3.1 shall be reinstated at such time as the Company is no longer actively employing its commercially
reasonable efforts to cause such registration statement to become effective. 

  
 -15- 

 (d) Inspection Rights. The Company shall permit each Major Investor to visit and
inspect the properties of the Company, to examine its corporate and financial records and make copies thereof and to discuss its affairs, finances, and accounts with its executive officers, at such reasonable times during normal business hours and
upon such reasonable notice of no less than three (3) business days; provided that (i) the Company consent to such inspection, which such consent shall not be unreasonably withheld and (ii) that such eligible Preferred Holder agrees
to abide by all Company policies, rules and regulations, including those regarding access to restricted areas on the Company’s properties and confidentiality. 

3.2 Confidentiality. Anything in this Agreement to the contrary notwithstanding, no Holder by reason of this Agreement shall have
access to any trade secrets or classified information of the Company. The Company shall not be required to comply with any information rights of Section 3 in respect of any Holder whom the Board of Directors of the Company
reasonably determines to be a competitor or an officer, employee, director or holder of more than ten percent (10%) of a competitor. Each Holder acknowledges that the information received by them pursuant to this Agreement may be confidential and
for its internal use only, and it will not use such confidential information in violation of the Exchange Act or reproduce, disclose or disseminate such information to any other person (other than its employees or agents having a need to know the
contents of such information, and its attorneys), except in connection with the exercise of rights under this Agreement, unless such information has become available to the public generally without any breach by the Holder of this
Section 3.2. 
 3.3 Reservation of Common Stock. On and after the date hereof, the Company will reserve and
keep reserved at all times sufficient shares of Common Stock for issuance upon conversion of the Shares. Immediately prior to the occurrence of any event that would cause the number of shares of Common Stock or type of securities into which the
Shares would be convertible to be adjusted, the Company shall take any and all actions necessary to permit such conversion. 
 3.4 Use of
Proceeds. The proceeds from the sale of the Series 6 Preferred pursuant to the Series 6 Purchase Agreement (the “Proceeds”) may be used by the Company for working capital, capital expenditures, sales and marketing and
research and development. 
 3.5 Protection of Intellectual Property. The Company shall use commercially reasonable efforts to
protect its proprietary intellectual property, trade secrets and know-how, including, but not limited to, (i) the keeping of proper laboratory notebooks, (ii) the use of secure storage, and
(iii) obtaining proprietary information and invention assignment agreements, which shall include appropriate confidentiality provisions, from all employees and consultants (excluding the members of the Company’s advisory board), upon the
commencement of their employment or service to the Company, in substantially the form delivered to the Investors, subject to amendments approved by the Company’s Board of Directors and which agreements shall be reviewed and renewed, if
necessary, on an annual basis as determined by the Board of Directors. 
 3.6 Observer Rights. So long as each of EW Healthcare
Partners Fund 2, L.P.and its affiliated entities (collectively, “EW”) and PTV IV, L.P. and its affiliated entities (collectively, “PTV”), individually and not collectively, hold shares of the Company’s capital
stock (each an “Investor with Observer Rights”), the Company covenants and agrees that each Investor with Observer Rights shall each be entitled to designate one observer (each an “Observer” and together, the
“Observers”). The Observers may be present at all meetings of the Board of Directors of the Company and any committees thereof, including any telephonic meetings and executive sessions, and that the Company will give such Observers
notice of 

  
 -16- 

 
such meetings, by telecopy or by such other means as such notices are delivered to the members of the Board of Directors of the Company, not later than the same time notice is provided or
delivered to the Board of Directors of the Company; provided, that the Observers shall be subject to the confidentiality provisions set forth in Section 3.2 hereof; provided, further, that the Observers may be
excluded from access to any material or meeting or portion thereof (i) if the Company believes upon advice of counsel that such exclusion is reasonably necessary to preserve the attorney-client privilege, (ii) to protect confidential or
proprietary information or (iii) for other similar reasons. For purposes of clarity, nothing herein shall be construed to mean that in the event that EW or PTV is no longer an Investor with Observer Rights, that any other Investors with
Observer Rights shall lose their right pursuant to this Section 3.6 to designate an Observer. 
 3.7
Termination of Covenants. The covenants set forth in this Section 3 shall terminate and be of no further force and effect with respect to the earliest to occur of (i) the Company’s Initial Public Offering,
(ii) the date on which this Agreement is terminated by a writing executed by (A) Holders party to this Agreement holding at least a majority of the shares of Preferred Stock (voting together as a single class) then held by all such Holders
and (B) Holders party to this Agreement holding at least a majority of the shares of Series 6 Preferred Stock (voting together as a single class) then held by all such Holders, (iii) the dissolution or
winding-up of the Company, or (iv) immediately prior to the effective date of a Change of Control. 

Section 4 
 Right
of First Refusal 
 4.1 Right of First Refusal. The Company hereby grants to each Preferred Holder the right of first refusal
to purchase its pro rata share of New Securities (as defined in Section 4.1(a)) which the Company may, from time to time, propose to sell and issue after the date of this Agreement. A Preferred Holder’s pro rata share,
for purposes of Section 4, is equal to the ratio of (a) the number of shares of Common Stock owned by such Preferred Holder immediately prior to the issuance of New Securities (assuming full conversion of the Shares
and exercise of all outstanding convertible securities, rights, options and warrants, directly or indirectly, into Common Stock held by said Preferred Holder) to (b) the total number of shares of Common Stock outstanding immediately prior to
the issuance of New Securities (assuming full conversion of the Shares and exercise of all outstanding convertible securities, rights, options and warrants, directly or indirectly, held by all Preferred Holders). 

(a) “New Securities” shall mean any capital stock (including Common Stock and/or Preferred Stock) of the Company whether now
authorized or not, and rights, convertible securities, options or warrants to purchase such capital stock, and securities of any type whatsoever that are, or may become, exercisable or convertible into capital stock; provided that the term
“New Securities” does not include securities excluded from the definition of “Additional Shares of Common” pursuant to Article FOURTH, Subsection 4(d)(i) of the Amended and Restated Certificate of Incorporation of the
Company. 
 (b) In the event the Company proposes to undertake an issuance of New Securities, it shall give each Preferred Holder written
notice of its intention, describing the type of New Securities, and their price and the general terms upon which the Company proposes to issue the same. Each Preferred Holder shall have ten (10) days after any such notice is mailed or delivered
to agree to purchase such Preferred Holder’s pro rata share of such New Securities for the price and upon the terms specified in the notice by giving written notice to the Company and stating therein the quantity of New Securities to be
purchased. 
 (c) In the event the Preferred Holders fail to exercise fully the right of first refusal within said ten (10) day period
(the “Election Period”), the Company shall have ninety (90) days thereafter 

  
 -17- 

 
to sell or enter into an agreement (pursuant to which the sale of New Securities covered thereby shall be closed, if at all, within ninety (90) days from the date of said agreement) to sell
that portion of the New Securities with respect to which the Preferred Holders’ right of first refusal option set forth in this Section 4.1 was not exercised, at a price and upon terms no more favorable to the
purchasers thereof than specified in the Company’s notice to the Preferred Holders delivered pursuant to Section 4.1(b). In the event the Company has not sold within the later of such ninety (90) day period
following the end of the Election Period, or such ninety (90) day period following the date of said agreement, the Company shall not thereafter issue or sell any New Securities, without first again offering such securities to the Preferred
Holders in the manner provided in this Section 4.1. 
 (d) The right of first refusal granted under this Agreement
shall expire upon, and shall not be applicable to, the Company’s Initial Public Offering. 
 Section 5 

Miscellaneous 
 5.1
Amendment. Except as expressly provided herein, neither this Agreement nor any term hereof may be amended, waived, discharged or terminated other than by a written instrument referencing this Agreement and signed by (i) the Company,
(ii) Holders party to this Agreement holding at least a majority of the shares of Registrable Securities (excluding any of such shares that have been sold to the public or pursuant to Rule 144) then held by all such Holders and (iii) if
the waiver, amendment, modification or termination adversely affects the rights or privileges of the Series 6 Preferred Stock or grants any rights or privileges to the Series 3 Preferred Stock, Series 4 Preferred Stock or Series 5 Preferred Stock
not also afforded to the Series 6 Preferred Stock, then Holders party to this Agreement holding at least a majority of the shares of Series 6 Preferred Stock then held by all such Holders; provided, however, that Holders purchasing shares of Series
6 Preferred Stock after the date of this Agreement may become parties to this Agreement by executing a counterpart of this Agreement without any amendment of this Agreement pursuant to this paragraph or any consent or approval of any other Holder.
Any such amendment, waiver, discharge or termination effected in accordance with this paragraph shall be binding upon each Holder and each future holder of all such securities of Holder. Notwithstanding the foregoing, this Agreement may not be
amended, waived, discharged or terminated with respect to any Holder party to this Agreement without the written consent of such Holder unless such waiver, amendment, modification or termination applies to all Holders party to this Agreement in the
same fashion, it being agreed that an amendment, modification, termination, or waiver shall be deemed to apply to all Holders, respectively, in the same fashion if such amendment, modification, termination, or waiver does so by its terms,
notwithstanding the fact that certain Holders may nonetheless receive different economics solely because of differences in dividend yields, liquidation preferences, anti-dilution adjustments or conversion rights among different classes of capital
stock of the Company as set forth in the Company’s Amended and Restated Certificate of Incorporation. 
 5.2 Notices. All
notices and other communications required or permitted hereunder shall be in writing and shall be mailed by registered or certified mail, postage prepaid, sent by facsimile or electronic mail or otherwise delivered by hand or by messenger addressed:

 (a) if to any holder of the capital stock of the Company at such holder’s address, facsimile number or electronic mail address as
shown in the Company’s records, as may be updated in accordance with the provisions hereof; 
 (b) if to any Holder, at such address,
facsimile number or electronic mail address as shown in the Company’s records, or, until any such holder so furnishes an address, facsimile number or electronic mail address to the Company, then to and at the address of the last holder of such
shares for which the Company has contact information in its records; or 

  
 -18- 

 (c) if to the Company, one copy should be sent to Attn: Chief Executive Officer, 1615 Wyatt
Drive, Santa Clara, CA 95054, fax number: (650) 964-8911, or at such other address as the Company shall have furnished to the Investors, with a copy (which shall not constitute notice) to Mark Weeks, Cooley
LLP, 3175 Hanover St, Palo Alto, CA 94304, fax number (650) 849-7400, electronic mail address: mweeks@cooley.com; or 

Each such notice or other communication shall for all purposes of this Agreement be treated as effective or having been given when delivered
if delivered personally, or, if sent by mail, at the earlier of its receipt or seventy-two (72) hours after the same has been deposited in a regularly maintained receptacle for the deposit of the United
States mail, addressed and mailed as aforesaid or, if sent by fax, upon confirmation of fax transfer or, if sent by electronic mail, upon confirmation of delivery when directed to the e- mail address set forth
on the Schedule of Investors. 
 5.3 Governing Law. This Agreement and all acts and transactions pursuant hereto and the rights and
obligations of the parties hereto shall be governed, construed and interpreted in all respects in accordance with the General Corporation Law of the State of Delaware as to matters governed by such General Corporation Law, and as to all other
matters in accordance with the laws of the State of Delaware without regard to its choice of laws principles. 
 5.4 Successors and
Assigns. Except as provided in Section 2.8, this Agreement, and any and all rights, duties and obligations hereunder, shall not be assigned, transferred, delegated or sublicensed by any Holder without the prior written
consent of the Company. Any attempt by a Holder without such permission to assign, transfer, delegate or sublicense any rights, duties or obligations that arise under this Agreement shall be void. Subject to the foregoing and except as otherwise
provided herein, the provisions of this Agreement shall inure to the benefit of, and be binding upon, the successors, assigns, heirs, executors and administrators of the parties hereto. 

5.5 Entire Agreement. This Agreement and the exhibits hereto constitute the full and entire understanding and agreement between the
parties with regard to the subjects hereof. No party hereto shall be liable or bound to any other party in any manner with regard to the subjects hereof or thereof by any warranties, representations or covenants except as specifically set forth
herein. 
 5.6 Delays or Omissions. Except as expressly provided herein, no delay or omission to exercise any right, power or remedy
accruing to any party to this Agreement upon any breach or default of any other party under this Agreement shall impair any such right, power or remedy of such non-defaulting party, nor shall it be construed
to be a waiver of any such breach or default, or an acquiescence therein, or of or in any similar breach or default thereafter occurring, nor shall any waiver of any single breach or default be deemed a waiver of any other breach or default
theretofore or thereafter occurring. Any waiver, permit, consent or approval of any kind or character on the part of any party of any breach or default under this Agreement, or any waiver on the part of any party of any provisions or conditions of
this Agreement, must be in writing and shall be effective only to the extent specifically set forth in such writing. All remedies, either under this Agreement or by law or otherwise afforded to any party to this Agreement, shall be cumulative and
not alternative. 
 5.7 Severability. If one or more provisions of this Agreement are held to be unenforceable under applicable law,
the parties agree to renegotiate such provision in good faith so as to effect the original intent of the parties as closely as possible in an acceptable manner in order that the transactions contemplated hereby are consummated as originally
contemplated to the greatest extent possible. In the 

  
 -19- 

 
event that the parties cannot reach a mutually agreeable and enforceable replacement for such provision, then (a) such provision shall be excluded from this Agreement, (b) the balance
of the Agreement shall be interpreted as if such provision were so excluded and (c) the balance of the Agreement shall be enforceable in accordance with its terms; provided that no such severability shall be effective if it materially changes
the economic benefit of this Agreement to any party or deprive such party of its essential bargain hereunder. 
 5.8 Titles and
Subtitles. The titles and subtitles used in this Agreement are used for convenience only and are not to be considered in construing or interpreting this Agreement. All references in this Agreement to sections, paragraphs and exhibits shall,
unless otherwise provided, refer to sections and paragraphs hereof and exhibits attached hereto. 
 5.9 Counterparts. This Agreement
may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (including pdf or any
electronic signature complying with the U.S. federal ESIGN Act of 2000, the Uniform Electronic Transactions Act or other applicable law) or other transmission method and any counterpart so delivered shall be deemed to have been duly and validly
delivered and be valid and effective for all purposes. 
 5.10 Jurisdiction; Venue. With respect to any disputes arising out of or
related to this Agreement, the parties consent to the sole and exclusive jurisdiction of, and venue in, the state courts in Santa Clara County in the State of California (or in the event of sole and exclusive federal jurisdiction, the courts of the
Northern District of California). 
 5.11 Further Assurances. Each party hereto agrees to execute and deliver, by the proper exercise
of its corporate, limited liability company, partnership or other powers, all such other and additional instruments and documents and do all such other acts and things as may be reasonably necessary to more fully effectuate this Agreement. 

5.12 Attorneys’ Fees. In the event that any suit or action is instituted to enforce any provision in this Agreement,
the prevailing party in such dispute shall be entitled to recover from the losing party such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation, all fees, costs and expenses of appeals. 

5.13 Aggregation of Stock. All shares of Registrable Securities held or acquired by affiliated persons or entities of a Holder shall be
aggregated together for the purpose of determining the availability of any rights under this Agreement. 
 5.14 Amendment and Restatement
of the Prior Rights Agreement. By execution of this Agreement, the Company and the undersigned Holders hereby amend and restate the Prior Rights Agreement as set forth herein. 

(Signature Page Follows) 

  
 -20- 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 COMPANY:
  

CARDIVA MEDICAL, INC. 
 a Delaware
corporation

		
	By:	 	 /s/ John Russell 

		
	Name:	 	 John Russell 

		
	Title:	 	Chief Executive Officer

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:
  

EW HEALTHCARE PARTNERS FUND 2, L.P. 

		
	By:	 	 EW Healthcare Partners Fund 2-GP, L.P. 

	 Its:
	 	 General Partner 

		 	
	By:	 	EW Healthcare Partners Fund 2-UGP, LLC
	Its:	 	General Partner
		 	
	By:	 	/s/ R. Scott Barry
		
	Name:	 	R. Scott Barry
		
	Title:	 	Authorized Signatory

  

			
	 EW HEALTHCARE PARTNERS FUND 2-A, L.P. 

		
	By:	 	 EW Healthcare Partners Fund 2-GP, L.P.

	 Its:
	 	 General Partner

		 	
	By:	 	EW Healthcare Partners Fund 2-UGP, LLC
	Its:	 	General Partner
		 	
	By:	 	/s/ R. Scott Barry
		
	Name:	 	R. Scott Barry
		
	Title:	 	Authorized Signatory

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:
  

PTV SCIENCES II, L.P.

		
	By:	 	 Pinto Technology Ventures GP II, LP, 

	 its
	 	 General Partner

		 	
	By:	 	 Pinto TV GP Company LLC, 

	its	 	General Partner
		 	
	By:	 	 /s/ Matthew Crawford 

		
	Name:	 	 Matthew Crawford 

		
	Title:	 	 Managing Director 

  

			
	 PTV IV, L.P. 

		
	By:	 	 PTV GP IV L.P., 

	 its
	 	 General Partner

		 	
	By:	 	 PTV GP III Management LLC, 

	its	 	General Partner
		 	
	By:	 	 /s/ Matthew Crawford

		
	Name:	 	 Matthew Crawford

		
	Title:	 	 Managing Director

  

			
	 PTV CM SPV, LLC 

		
	By:	 	 PTV CM SPV, LLC, 

	 its
	 	 General Partner

		 	
	By:	 	 PTV GP III Management LLC, 

	its	 	General Partner
		 	
	By:	 	 /s/ Matthew Crawford

		
	Name:	 	 Matthew Crawford

		
	Title:	 	 Managing Director

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	/s/ Francisco F. Rodriguez
	(Signature)
	
	RIND, LTD.
	(Name of Holder)
	
	Francisco F. Rodriguez, Director
	(Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Michael Bornitz 

	(Signature)
	
	 301 CARDIVA PARTNERS, LLC 

	(Name of Holder)
	
	 Michael Bornitz Manager 

	 (Name and Title of Signatory, if Applicable) 

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Augustine Lien 

	(Signature)
	
	 THE LIEN FAMILY LIVING TRUST, DATED MARCH 5, 2003 

	(Name of Holder)
	
	 Augustine Lien 

	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Fu Lung-Shu
                June 22, 2020 

	(Signature)
	
	 JACK INVESTMENT CO., LTD. 

	(Name of Holder)
	
	 Fu Lung-Shu, CEO 

	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Ping Liu 

	(Signature)
	
	 PING LIU 

	(Name of Holder)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Wen Han Chen
                June 18, 2020 

	(Signature)
	
	 CROWN INVESTMENT WORLDWIDE, LTD. 

	(Name of Holder)
	
	 Wen Han Chen, C.E.O. 

	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Jyan Ming Hang 

	(Signature)
	
	 HERCULES BIOVENTURE, L.P. 

	(Name of Holder)
	
	 Jyan Ming Hang

 
 Geeneral Partner

	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Shang Techan 

	(Signature)
	
	 REDPINE FINANCE HOLDINGS, INC. 

	(Name of Holder)
	
	 SHANG TECHAN, Authorized Signatory 

	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ James Wang 

	(Signature)
	
	 NCKU VENTURE CAPITAL CO., LTD. 

	(Name of Holder)
	
	 James Wang, Chairman 

	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Fu Den Nan 

	(Signature)
	
	 FU DEN NAN (WILLIAM FU) 

	(Name of Holder)
	
	 
	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ George Lee 

	(Signature)
	
	 GEORGE J. LEE 

	(Name of Holder)
	
	 
	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Jonas Chia-Tsun Wang 

	(Signature)
	
	 JONAS CHIA-TSUN WANG 

	(Name of Holder)
	
	 
	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Sylvia Liu 

	(Signature)
	
	 SYLVIA LIU 

	(Name of Holder)
	
	 
	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ David P. Conklin /s/ Wendy Conklin 

	(Signature)
	
	 DAVID P. AND WENDY CONKLIN 

	(Name of Holder)
	
	 
	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Mark Klopp 

	(Signature)
	
	 MARK V. KLOPP 

	(Name of Holder)
	
	 
	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Michael Horgan 

	(Signature)
	
	 MICHAEL J. HORGAN 

	 (Name of Holder)

	
	 6/25/20

	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Ter-Shan Chen 

	(Signature)
	
	 BIO INTECH, LTD. 

	(Name of Holder)
	
	 Ter-Shan Chen, Manager

	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Dean Tsao 

	(Signature)
	
	 TSAO: DEAN PING TSAO FAMILY LIMITED PARTNERS NO. 2, LP 

	(Name of Holder)
	
	 Dean Tsao, GP 

	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 Kenneth E. Lipson 

	(Signature)
	
	 GLOBAL ASSETS INVESTMENT, LLC 

	(Name of Holder)
	
	 /s/ Kenneth E. Lipson, Member 

	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Michael Daniel 

	(Signature)
	
	 MICHAEL DANIEL 

	(Name of Holder)
	
	 
	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Wang Chia-Ho 

	(Signature)
	
	 SUNSINO INTERNATIONAL DEVELOPMENT ASSOCIATE INC. 

	(Name of Holder)
	
	 Chairman, Wang Chia-Ho

	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 IN WITNESS WHEREOF, the parties hereto have executed this Ninth Amended and Restated
Investors’ Rights Agreement effective as of the day and year first above written. 
  

			
	 HOLDER:

	
	 /s/ Killin To 

	(Signature)
	
	 KILLIN TO 

	(Name of Holder)
	
	 
	 (Name and Title of Signatory, if Applicable)

  

SIGNATURE PAGE TO CARDIVA MEDICAL, INC. 

NINTH AMENDED AND RESTATED INVESTORS’ RIGHTS
AGREEMENT 

 EXHIBIT A 

SECURITYHOLDERS 
 AmKey
Biotechnology Venture Capital, Inc. 
 AmKey Venture Capital, Inc. 

Bio Intech Ltd. 
 Chien-Chun Chang

 Chang Mein Kai 
 Tony Fon-Lein Chang 
 Yu San Elyn Chang 

Stephen Sun Chiao 
 David P. and
Wendy Conklin 
 Crown Investment Worldwide, Ltd. 

Michael A. Daniel 
 Der Yang
Biotechnology Venture Capital Co., ltd. 
 Eminent Venture Capital Corporation 

EW Healthcare Partners Fund 2, L.P. 

EW Healthcare Partners Fund 2-A, L.P. 

Eureka BioVenture Partners 
 Fu Den
Nan (William Fu) 
 Global Assets Investment, LLC 

Global Star International Co., Ltd. 

Hercules Bioventure, L.P. 
 Hanako
Hiramatsu 
 Michael J. Horgan 

Jack Investment Co., Ltd. 
 Mark V.
Klopp 
 George J. Lee, Ph.D. 

Maw Sheng Lee 
 Lexli Investment,
LLC 
 The Lien Family Trust, Dated March 5, 2003 

Ping Liu 
 Sylvia Liu 

Charles T. Maroney 
 Frederic H.
Moll 
 NCKU Venture Capital Co., Ltd. 

PTV Sciences II, L.P. 
 Redpine
Finance Holdings, Inc. 
 Rind, Ltd. 

Chun-Chien Shih 
 Jerry Shih 

Kilin To 
 Dean & Ping Tsao
Family Limited Partnership No. 2, LP 
 TSC BioVenture Capital Corporation 

Universal Migration Ltd. 
 Craig M.
Walker, M.D. 
 Jonas Chia-Tsun Wang 

PTV CM SPV, LLC 
 PTV IV, L.P. 

301 Cardiva Partners, LLC 
 Canepa
Advanced Healthcare Fund, L.P.EX-10.4

 Exhibit 10.4 

CARDIVA MEDICAL, INC. 

AMENDED AND RESTATED 2014 EQUITY INCENTIVE PLAN 

(as amended through June 29, 2020) 

1. Purpose. 
 The purpose
of the Plan is to advance the interests of the Company’s stockholders by enhancing the Company’s ability to attract, retain and motivate persons who make (or are expected to make) important contributions to the Company by providing such
persons with equity ownership opportunities and thereby better aligning the interests of such persons with those of the Company’s stockholders. Capitalized terms used in the Plan are defined in Section 11 below. 

2. Eligibility. 
 Service
Providers are eligible to be granted Awards under the Plan, subject to the limitations described herein. 
 3. Administration and
Delegation. 
 (a) Administration. The Plan will be administered by the Administrator. The Administrator shall have authority to
determine which Service Providers will receive Awards, to grant Awards and to set all terms and conditions of Awards (including, but not limited to, vesting, exercise and forfeiture provisions). In addition, the Administrator shall have the
authority to take all actions and make all determinations contemplated by the Plan and to adopt, amend and repeal such administrative rules, guidelines and practices relating to the Plan as it shall deem advisable. The Administrator may correct any
defect or ambiguity, supply any omission or reconcile any inconsistency in the Plan or any Award in the manner and to the extent it shall deem necessary or appropriate to carry the Plan and any Awards into effect, as determined by the Administrator.
The Administrator shall make all determinations under the Plan in the Administrator’s sole discretion and all such determinations shall be final and binding on all persons having or claiming any interest in the Plan or in any Award. 

(b) Appointment of Committees. To the extent permitted by Applicable Laws, the Board may delegate any or all of its powers under the
Plan to one or more Committees. The Board may abolish any Committee at any time and re-vest in itself any previously delegated authority. 

4. Stock Available for Awards. 

(a) Number of Shares. Subject to adjustment under Section 8 hereof, Awards may be made under the Plan covering up to a maximum of
the sum of (i) 23,023,918 (such number is after giving effect to the reverse stock split on February 7, 2014) shares of Common Stock and (ii) any of the 395 (such number is after giving effect to the reverse stock split on February 7,
2014) shares of Common Stock which as of the Effective Date are subject to awards under the 

  
 1 

 
Prior Plan which are forfeited or lapse unexercised and which following the Effective Date are not issued under the Prior Plan. If any Award expires or lapses or is terminated, surrendered or
canceled without having been fully exercised or is forfeited in whole or in part (including as the result of shares of Common Stock subject to such Award being repurchased by the Company at or below the original issuance price), in any case in a
manner that results in any shares of Common Stock covered by such Award not being issued or being so reacquired by the Company, the unused Common Stock covered by such Award shall again be available for the grant of Awards under the Plan. Further,
shares of Common Stock delivered (either by actual delivery or attestation) to the Company by a Participant to satisfy the applicable exercise or purchase price of an Award and/or to satisfy any applicable tax withholding obligation (including
shares retained by the Company from the Award being exercised or purchased and/or creating the tax obligation) shall be added to the number of shares of Common Stock available for the grant of Awards under the Plan. However, in the case of Incentive
Stock Options (as hereinafter defined), the foregoing provisions shall be subject to any limitations under the Code. Shares of Common Stock issued under the Plan may consist in whole or in part of authorized but unissued shares, shares purchased on
the open market or treasury shares. 
 (b) Substitute Awards. In connection with a merger or consolidation of an entity with the
Company or the acquisition by the Company of property or stock of an entity, the Administrator may grant Awards in substitution for any options or other stock or stock-based awards granted prior to such merger or consolidation by such entity or an
affiliate thereof. Substitute Awards may be granted on such terms as the Administrator deems appropriate in the circumstances, notwithstanding any limitations on Awards contained in the Plan. Substitute Awards shall not count against the overall
share limit set forth in Section 4(a) hereof, except as may be required by reason of Section 422 of the Code. 
 5. Stock
Options. 
 (a) General. The Administrator may grant Options to any Service Provider, subject to the limitations on Incentive
Stock Options described below. The Administrator shall determine the number of shares of Common Stock to be covered by each Option, the exercise price of each Option and the conditions and limitations applicable to the exercise of each Option,
including conditions relating to Applicable Laws, as it considers necessary or advisable. 
 (b) Incentive Stock Options. The
Administrator may grant Options intended to qualify as Incentive Stock Options only to employees of the Company, any of the Company’s present or future “parent corporations” or “subsidiary corporations” as defined in
Sections 424(e) or (f) of the Code, respectively, and any other entities the employees of which are eligible to receive Incentive Stock Options under the Code. All Options intended to qualify as Incentive Stock Options shall be subject to and
shall be construed consistently with the requirements of Section 422 of the Code. Neither the Company nor the Administrator shall have any liability to a Participant, or any other party, (i) if an Option (or any part thereof) which is
intended to qualify as an Incentive Stock Option fails to qualify as an Incentive Stock Option or (ii) for any action or omission by the Administrator that causes an Option not to qualify as an Incentive Stock Option, including without
limitation, the conversion of an Incentive Stock Option to a Non-Qualified Stock Option or the grant of an Option intended as an Incentive Stock Option that fails to satisfy the requirements under the Code
applicable to an Incentive Stock Option. Any Option that is intended 

  
 2 

 
to qualify as an Incentive Stock Option, but fails to so qualify for any reason, including without limitation, the portion of any Option becoming exercisable in excess of the $100,000 limitation
described in Treasury Regulation Section 1.422-4, shall be treated as a Non-Qualified Stock Option for all purposes. 

(c) Exercise Price. The Administrator shall establish the exercise price of each Option and specify the exercise price in the
applicable Award Agreement. The exercise price shall be not less than 100% of the Fair Market Value on the date the Option is granted. In the case of an Incentive Stock Option granted to an employee who, at the time of grant of the Option, owns (or
is treated as owning under Section 424 of the Code) stock representing more than 10% of the voting power of all classes of stock of the Company (or a “parent corporation” or “subsidiary corporation” thereof within the
meaning of Sections 424(e) or 424(f) of the Code, respectively), the per share exercise price shall be no less than 110% of the Fair Market Value on the date the Option is granted. 

(d) Duration of Options. Each Option shall be exercisable at such times and subject to such terms and conditions as the Administrator
may specify in the applicable Award Agreement, provided that the term of any Option shall not exceed ten years. In the case of an Incentive Stock Option granted to an employee who, at the time of grant of the Option, owns (or is treated as owning
under Section 424 of the Code) stock representing more than 10% of the voting power of all classes of stock of the Company (or a “parent corporation” or “subsidiary corporation” thereof within the meaning of Sections 424(e)
or 424(f) of the Code, respectively), the term of the Option shall not exceed five years. 
 (e) Exercise of Option; Notification of
Disposition. Options may be exercised by delivery to the Company of a written notice of exercise, in a form approved by the Administrator (which may be an electronic form), signed by the person authorized to exercise the Option, together with
payment in full (i) as specified in Section 5(f) hereof for the number of shares for which the Option is exercised and (ii) as specified in Section 9(e) hereof for any applicable withholding taxes. Unless otherwise determined by
the Administrator, an Option may not be exercised for a fraction of a share of Common Stock. If an Option is designated as an Incentive Stock Option, the Participant shall give prompt notice to the Company of any disposition or other transfer of any
shares of Common Stock acquired from the Option if such disposition or transfer is made (i) within two years from the grant date with respect to such Option or (ii) within one year after the transfer of such shares to the Participant
(other than any such disposition made in connection with a Change in Control). Such notice shall specify the date of such disposition or other transfer and the amount realized, in cash, other property, assumption of indebtedness or other
consideration, by the Participant in such disposition or other transfer. 
 (f) Payment Upon Exercise. Common Stock purchased upon
the exercise of an Option granted under the Plan shall be paid for in cash or by check, payable to the order of the Company, or, to the extent permitted by the Administrator, by: 

(i) (A) delivery of an irrevocable and unconditional undertaking by a broker acceptable to the Company to deliver promptly to
the Company sufficient funds to pay the exercise price and any required tax withholding, or (B) delivery by the Participant to the Company of a copy of irrevocable and unconditional instructions to a broker acceptable to the Company to deliver
promptly to the Company cash or a check sufficient to pay the exercise price and any required tax withholding; 

  
 3 

 (ii) delivery (either by actual delivery or attestation) of shares of Common
Stock owned by the Participant valued at their Fair Market Value, provided (A) such method of payment is then permitted under Applicable Laws, (B) such Common Stock, if acquired directly from the Company, was owned by the Participant for
such minimum period of time, if any, as may be established by the Company at any time, and (C) such Common Stock is not subject to any repurchase, forfeiture, unfulfilled vesting or other similar requirements; 

(iii) surrendering shares of Common Stock then issuable upon exercise of the Option valued at their Fair Market Value on the
date of exercise; 
 (iv) delivery of a promissory note of the Participant to the Company on terms determined by the
Administrator; 
 (v) delivery of property of any other kind which constitutes good and valuable consideration as determined
by the Administrator; or 
 (vi) any combination of the above permitted forms of payment (including cash or check). 

(g) Early Exercise of Options. The Administrator may provide in the terms of an Award Agreement that the Service Provider may exercise
an Option in whole or in part prior to the full vesting of the Option in exchange for unvested shares of Restricted Stock with respect to any unvested portion of the Option so exercised. Shares of Restricted Stock acquired upon the exercise of any
unvested portion of an Option shall be subject to such terms and conditions as the Administrator shall determine. 
 6. Restricted Stock;
Restricted Stock Units. 
 (a) General. The Administrator may grant Restricted Stock, or the right to purchase Restricted Stock,
to any Service Provider, subject to the right of the Company to repurchase all or part of such shares at their issue price or other stated or formula price from the Participant (or to require forfeiture of such shares if issued at no cost) in the
event that conditions specified by the Administrator in the applicable Award Agreement are not satisfied prior to the end of the applicable restriction period or periods established by the Administrator for such Award. In addition, the Administrator
may grant to Service Providers Restricted Stock Units, which may be subject to vesting and forfeiture conditions during applicable restriction period or periods, as set forth in an applicable Award Agreement. 

(b) Terms and Conditions for All Restricted Stock and Restricted Stock Unit Awards. The Administrator shall determine and set forth in
the applicable Award Agreement the terms and conditions applicable to each Restricted Stock and Restricted Stock Unit Award, including the conditions for vesting and repurchase (or forfeiture) and the issue price, in each case, if any. 

  
 4 

 (c) Additional Provisions Relating to Restricted Stock. 

(i) Dividends. Participants holding shares of Restricted Stock will be entitled to all ordinary cash dividends paid with
respect to such shares, unless otherwise provided by the Administrator in the applicable Award Agreement. In addition, unless otherwise provided by the Administrator, if any dividends or distributions are paid in shares, or consist of a dividend or
distribution to holders of Common Stock of property other than an ordinary cash dividend, the shares or other property will be subject to the same restrictions on transferability and forfeitability as the shares of Restricted Stock with respect to
which they were paid. Each dividend payment will be made as provided in the applicable Award Agreement, but in no event later than the end of the calendar year in which the dividends are paid to stockholders of that class of stock or, if later, the
15th day of the third month following the later of (A) the date the dividends are paid to stockholders of that class of stock, and (B) the date the dividends are no longer subject to forfeiture. 

(ii) Stock Certificates. The Company may require that any stock certificates issued in respect of shares of Restricted
Stock be deposited in escrow by the Participant, together with a stock power endorsed in blank, with the Company (or its designee). 
 (d)
Additional Provisions Relating to Restricted Stock Units. 
 (i) Settlement. Upon the vesting of a Restricted
Stock Unit, the Participant shall be entitled to receive from the Company one share of Common Stock or an amount of cash or other property equal to the Fair Market Value of one share of Common Stock on the settlement date, as the Administrator shall
determine and as provided in the applicable Award Agreement. The Administrator may provide that settlement of Restricted Stock Units shall occur upon or as soon as reasonably practicable after the vesting of the Restricted Stock Units or shall
instead be deferred, on a mandatory basis or at the election of the Participant, in a manner that complies with Section 409A. 

(ii) Voting Rights. A Participant shall have no voting rights with respect to any Restricted Stock Units unless and
until shares are delivered in settlement thereof. 
 (iii) Dividend Equivalents. To the extent provided by the
Administrator, a grant of Restricted Stock Units may provide a Participant with the right to receive Dividend Equivalents. Dividend Equivalents may be paid currently or credited to an account for the Participant, may be settled in cash and/or shares
of Common Stock and may be subject to the same restrictions on transfer and forfeitability as the Restricted Stock Units with respect to which the Dividend Equivalents are paid, as determined by the Administrator, subject, in each case, to such
terms and conditions as the Administrator shall establish and set forth in the applicable Award Agreement. 
 7. Other Stock-Based
Awards. 
 Other Stock-Based Awards may be granted hereunder to Participants, including, without limitation, Awards entitling
Participants to receive shares of Common Stock to be delivered in the future. Such Other Stock-Based Awards shall also be available as a form of 

  
 5 

 
payment in the settlement of other Awards granted under the Plan, as stand-alone payments and/or as payment in lieu of compensation to which a Participant is otherwise entitled. Other Stock-Based
Awards may be paid in shares of Common Stock, cash or other property, as the Administrator shall determine. Subject to the provisions of the Plan, the Administrator shall determine the terms and conditions of each Other Stock-Based Award, including
any purchase price, transfer restrictions, vesting conditions and other terms and conditions applicable thereto, which shall be set forth in the applicable Award Agreement. 

8. Adjustments for Changes in Common Stock and Certain Other Events. 

(a) In the event that the Administrator determines that any dividend or other distribution (whether in the form of cash, Common Stock, other
securities, or other property), reorganization, merger, consolidation, combination, repurchase, recapitalization, liquidation, dissolution, or sale, transfer, exchange or other disposition of all or substantially all of the assets of the Company, or
sale or exchange of Common Stock or other securities of the Company, issuance of warrants or other rights to purchase Common Stock or other securities of the Company, or other similar corporate transaction or event, as determined by the
Administrator, affects the Common Stock such that an adjustment is determined by the Administrator to be appropriate in order to prevent dilution or enlargement of the benefits or potential benefits intended by the Company to be made available under
the Plan or with respect to any Award, then the Administrator may, in such manner as it may deem equitable, adjust any or all of: 

(i) the number and kind of shares of Common Stock (or other securities or property) with respect to which Awards may be granted
or awarded (including, but not limited to, adjustments of the limitations in Section 4 hereof on the maximum number and kind of shares which may be issued); 

(ii) the number and kind of shares of Common Stock (or other securities or property) subject to outstanding Awards; 

(iii) the grant or exercise price with respect to any Award; and 

(iv) the terms and conditions of any Awards (including, without limitation, any applicable financial or other performance
“targets” specified in an Award Agreement). 
 (b) In the event of any transaction or event described in Section 8(a) hereof
(including without limitation any Change in Control) or any unusual or nonrecurring transaction or event affecting the Company or the financial statements of the Company, or any change in any Applicable Laws or accounting principles, the
Administrator, on such terms and conditions as it deems appropriate, either by the terms of the Award or by action taken prior to the occurrence of such transaction or event and either automatically or upon the Participant’s request, is hereby
authorized to take any one or more of the following actions whenever the Administrator determines that such action is appropriate in order to (x) prevent dilution or enlargement of the benefits or potential benefits intended by the Company to
be made available under the Plan or with respect to any Award granted or issued under the Plan, (y) to facilitate such transaction or event or (z) give effect to such changes in Applicable Laws or accounting principles: 

  
 6 

 (i) To provide for the cancellation of any such Award in exchange for either
an amount of cash or other property with a value equal to the amount that could have been obtained upon the exercise or settlement of the vested portion of such Award or realization of the Participant’s rights under the vested portion of such
Award, as applicable; provided that, if the amount that could have been obtained upon the exercise or settlement of the vested portion of such Award or realization of the Participant’s rights, in any case, is equal to or less than zero, then
the vested portion of such Award may be terminated without payment; 
 (ii) To provide that such Award shall vest and, to the
extent applicable, be exercisable as to all shares covered thereby, notwithstanding anything to the contrary in the Plan or the provisions of such Award; 

(iii) To provide that such Award be assumed by the successor or survivor corporation, or a parent or subsidiary thereof, or
shall be substituted for by awards covering the stock of the successor or survivor corporation, or a parent or subsidiary thereof, with appropriate adjustments as to the number and kind of shares and applicable exercise or purchase price, in all
cases, as determined by the Administrator; 
 (iv) To make adjustments in the number and type of shares of Common Stock (or
other securities or property) subject to outstanding Awards, and/or in the terms and conditions of (including the grant or exercise price), and the criteria included in, outstanding Awards which may be granted in the future; 

(v) To replace such Award with other rights or property selected by the Administrator; and/or 

(vi) To provide that the Award will terminate and cannot vest, be exercised or become payable after the applicable event. 

(c) Notwithstanding the provisions of Section 8(b) above, if a Change in Control occurs and a Participant’s Awards are not
continued, converted, assumed, or replaced with a substantially similar award by (i) the Company, or (ii) a successor entity or its parent or subsidiary (an “Assumption”), and provided that the Participant has not had a
Termination of Service, then immediately prior to the Change in Control such Awards shall become fully vested, exercisable and/or payable, as applicable, and all forfeiture, repurchase and other restrictions on such Awards shall lapse, in which
case, such Awards shall be canceled upon the consummation of the Change in Control in exchange for the right to receive the Change in Control consideration payable to other holders of Common Stock (A) which may be on such terms and conditions
as apply generally to holders of Common Stock under the Change in Control documents (including, without limitation, any escrow, earn-out or other deferred consideration provisions) or such other terms and
conditions as the Administrator may provide, and (B) determined by reference to the number of shares subject to such Awards and net of any applicable exercise price; provided that to the extent that any Awards constitute “nonqualified
deferred compensation” that may not be paid upon the Change in Control under Section 409A without the imposition of taxes thereon under Section 409A, the timing of such payments shall be governed by the applicable Award Agreement
(subject to any deferred consideration provisions applicable under the Change in Control 

  
 7 

 
documents); and provided, further, that if the amount to which a Participant would be entitled upon the settlement or exercise of such Award at the time of the Change in Control is equal to or
less than zero, then such Award may be terminated without payment. The Administrator shall determine whether an Assumption of an Award has occurred in connection with a Change in Control. 

(d) In connection with the occurrence of any Equity Restructuring, and notwithstanding anything to the contrary in this Section 8, the
Administrator will equitably adjust each outstanding Award, which adjustments may include adjustments to the number and type of securities subject to each outstanding Award and/or the exercise price or grant price thereof, if applicable, the grant
of new Awards to Participants, and/or the making of a cash payment to Participants, as the Administrator deems appropriate to reflect such Equity Restructuring. The adjustments provided under this Section 8(e) shall be nondiscretionary and
shall be final and binding on the affected Participant and the Company; provided that whether an adjustment is equitable shall be determined by the Administrator. 

(e) In the event of any pending stock dividend, stock split, combination or exchange of shares, merger, consolidation or other distribution
(other than normal cash dividends) of Company assets to stockholders, or any other change affecting the shares of Common Stock or the share price of the Common Stock, including any Equity Restructuring, for reasons of administrative convenience the
Administrator may refuse to permit the exercise of any Award during a period of up to thirty days prior to the consummation of any such transaction. 

(f) Except as expressly provided in the Plan or pursuant to action of the Administrator under the Plan, no Participant shall have any rights
by reason of any subdivision or consolidation of shares of stock of any class, the payment of any dividend, any increase or decrease in the number of shares of stock of any class or any dissolution, liquidation, merger, or consolidation of the
Company or any other corporation. Except as expressly provided in the Plan or pursuant to action of the Administrator under the Plan, no issuance by the Company of shares of stock of any class, or securities convertible into shares of stock of any
class, shall affect, and no adjustment by reason thereof shall be made with respect to, the number of shares of Common Stock subject to an Award or the grant or exercise price of any Award. The existence of the Plan, any Award Agreements and the
Awards granted hereunder shall not affect or restrict in any way the right or power of the Company to make or authorize (i) any adjustment, recapitalization, reorganization or other change in the Company’s capital structure or its
business, (ii) any merger, consolidation dissolution or liquidation of the Company or sale of Company assets or (iii) any sale or issuance of securities, including without limitation, securities with rights superior to those of the Common
Stock or which are convertible into or exchangeable for Common Stock. The Administrator may treat Participants and Awards (or portions thereof) differently under this Section 8. 

9. General Provisions Applicable to Awards. 

(a) Transferability. Except as the Administrator may otherwise determine or provide in an Award Agreement or otherwise, in any case in
accordance with Applicable Laws, Awards shall not be sold, assigned, transferred, pledged or otherwise encumbered by the person to whom they are granted, either voluntarily or by operation of law, except by will or the laws of descent and
distribution, and, during the life of the Participant, shall be exercisable only by the Participant. References to a Participant, to the extent relevant in the context, shall include references to authorized transferees. 

  
 8 

 (b) Documentation. Each Award shall be evidenced in an Award Agreement, which may be
in such form (written, electronic or otherwise) as the Administrator shall determine. Each Award may contain terms and conditions in addition to those set forth in the Plan. 

(c) Discretion. Except as otherwise provided by the Plan, each Award may be made alone or in addition or in relation to any other
Award. The terms of each Award to a Participant need not be identical, and the Administrator need not treat Participants or Awards (or portions thereof) uniformly. 

(d) Termination of Status. The Administrator shall determine the effect on an Award of the disability, death, retirement, authorized
leave of absence or any other change or purported change in a Participant’s Service Provider status and the extent to which, and the period during which, the Participant, the Participant’s legal representative, conservator, guardian or
Designated Beneficiary may exercise rights under the Award, if applicable. 
 (e) Withholding. Each Participant shall pay to the
Company, or make provision satisfactory to the Administrator for payment of, any taxes required by law to be withheld in connection with Awards to such Participant no later than the date of the event creating the tax liability. Except as the
Administrator may otherwise determine, all such payments shall be made in cash or by certified check. Notwithstanding the foregoing, to the extent permitted by the Administrator, Participants may satisfy such tax obligations in whole or in part by
delivery of shares of Common Stock, including shares retained from the Award creating the tax obligation, valued at their Fair Market Value. The Company may, to the extent permitted by Applicable Laws, deduct any such tax obligations from any
payment of any kind otherwise due to a Participant. 
 (f) Amendment of Award. The Administrator may amend, modify or terminate any
outstanding Award, including but not limited to, substituting therefor another Award of the same or a different type, changing the date of exercise or settlement, and converting an Incentive Stock Option to a
Non-Qualified Stock Option. The Participant’s consent to such action shall be required unless (i) the Administrator determines that the action, taking into account any related action, would not
materially and adversely affect the Participant, or (ii) the change is permitted under Section 8 and 10(f) hereof. 
 (g)
Conditions on Delivery of Stock. The Company will not be obligated to deliver any shares of Common Stock pursuant to the Plan or to remove restrictions from shares previously delivered under the Plan until (i) all conditions of the Award
have been met or removed to the satisfaction of the Company, (ii) in the opinion of the Company’s counsel, all other legal matters in connection with the issuance and delivery of such shares have been satisfied, including any applicable
securities laws and any applicable stock exchange or stock market rules and regulations, and (iii) the Participant has executed and delivered to the Company such representations or agreements as the Administrator deems necessary or appropriate
to satisfy the requirements of any Applicable Laws. The inability of the Company to obtain authority from any regulatory body having jurisdiction, which authority is determined by the Administrator to be necessary to the lawful issuance and sale of
any securities hereunder, shall relieve the Company of any liability in respect of the failure to issue or sell such shares as to which such requisite authority shall not have been obtained. 

  
 9 

 (h) Acceleration. The Administrator may at any time provide that any Award shall
become immediately vested and/or exercisable in full or in part, free of some or all restrictions or conditions, or otherwise realizable in full or in part, as the case may be. 

10. Miscellaneous. 
 (a)
No Right To Employment or Other Status. No person shall have any claim or right to be granted an Award, and the grant of an Award shall not be construed as giving a Participant the right to continued employment or any other relationship with
the Company. The Company expressly reserves the right at any time to dismiss or otherwise terminate its relationship with a Participant free from any liability or claim under the Plan or any Award, except as expressly provided in an applicable Award
Agreement. 
 (b) No Rights As Stockholder; Certificates. Subject to the provisions of the applicable Award Agreement, no Participant
or Designated Beneficiary shall have any rights as a stockholder with respect to any shares of Common Stock to be distributed with respect to an Award until becoming the record holder of such shares. Notwithstanding any other provision of the Plan,
unless otherwise determined by the Administrator or required by any Applicable Laws, the Company shall not be required to deliver to any Participant certificates evidencing shares of Common Stock issued in connection with any Award and instead such
shares of Common Stock may be recorded in the books of the Company (or, as applicable, its transfer agent or stock plan administrator). The Company may place legends on stock certificates issued under the Plan deemed necessary or appropriate by the
Administrator in order to comply with Applicable Laws. 
 (c) Effective Date and Term of Plan. The Plan shall become effective on the
date on which it is adopted by the Board (the “Effective Date”). No Awards shall be granted under the Plan after the completion of ten years from the earlier of (i) the date on which the Plan was adopted by the Board or (ii) the
date the Plan was approved by the Company’s stockholders, but Awards previously granted may extend beyond that date in accordance with the terms of the Plan. 

(d) Amendment of Plan. The Administrator may amend, suspend or terminate the Plan or any portion thereof at any time; provided that no
amendment of the Plan shall materially and adversely affect any Award outstanding at the time of such amendment without the consent of the affected Participant. Awards outstanding under the Plan at the time of any suspension or termination of the
Plan shall continue to be governed in accordance with the terms of the Plan and the applicable Award Agreement, as in effect prior to such suspension or termination. The Board shall obtain stockholder approval of any Plan amendment to the extent
necessary to comply with Applicable Laws. 
 (e) Provisions for Foreign Participants. The Administrator may modify Awards granted to
Participants who are foreign nationals or employed outside the United States or establish subplans or procedures under the Plan to address differences in laws, rules, regulations or customs of such foreign jurisdictions with respect to tax,
securities, currency, employee benefit or other matters. 

  
 10 

 (f) Section 409A. 

(i) General. The Company intends that all Awards be structured in compliance with, or to satisfy an exemption from,
Section 409A, such that no adverse tax consequences, interest, or penalties under Section 409A apply in connection with any Awards. Notwithstanding anything herein or in any Award Agreement to the contrary, the Administrator may, without a
Participant’s prior consent, amend this Plan and/or Awards, adopt policies and procedures, or take any other actions (including amendments, policies, procedures and actions with retroactive effect) as are necessary or appropriate to preserve
the intended tax treatment of Awards under the Plan, including without limitation, any such actions intended to (A) exempt this Plan and/or any Award from the application of Section 409A, and/or (B) comply with the requirements of
Section 409A, including without limitation any such regulations, guidance, compliance programs and other interpretative authority that may be issued after the date of grant of any Award. The Company makes no representations or warranties as to
the tax treatment of any Award under Section 409A or otherwise. The Company shall have no obligation under this Section 10(f) or otherwise to take any action (whether or not described herein) to avoid the imposition of taxes, penalties or
interest under Section 409A with respect to any Award and shall have no liability to any Participant or any other person if any Award, compensation or other benefits under the Plan are determined to constitute
non-compliant, “nonqualified deferred compensation” subject to the imposition of taxes, penalties and/or interest under Section 409A. 

(ii) Separation from Service. With respect to any Award that constitutes “nonqualified deferred compensation”
under Section 409A, any payment or settlement of such Award that is to be made upon a termination of a Participant’s Service Provider relationship shall, to the extent necessary to avoid the imposition of taxes under Section 409A, be
made only upon the Participant’s “separation from service” (within the meaning of Section 409A), whether such “separation from service” occurs upon or subsequent to the termination of the Participant’s Service
Provider relationship. For purposes of any such provision of this Plan or any Award Agreement relating to any such payments or benefits, references to a “termination,” “termination of employment” or like terms shall mean
“separation from service.” 
 (iii) Payments to Specified Employees. Notwithstanding any contrary provision
in the Plan or any Award Agreement, any payment(s) of “nonqualified deferred compensation” that are otherwise required to be made under an Award to a “specified employee” (as defined under Section 409A and determined by the
Administrator) as a result of his or her “separation from service” shall, to the extent necessary to avoid the imposition of taxes under Code Section 409A(a)(2)(B)(i), be delayed until the expiration of the six-month period immediately following such “separation from service” (or, if earlier, until the date of death of the specified employee) and shall instead be paid (in a manner set forth in the Award
agreement) on the day that immediately follows the end of such six-month period or as soon as administratively practicable thereafter (without interest). Any payments of “nonqualified deferred
compensation” under such Award that are, by their terms, payable more than six months following the Participant’s “separation from service” shall be paid at the time or times such payments are otherwise scheduled to be made. 

  
 11 

 (g) Limitations on Liability. Notwithstanding any other provisions of the Plan, no
individual acting as a director, officer, other employee or agent of the Company will be liable to any Participant, former Participant, spouse, beneficiary, or any other person for any claim, loss, liability, or expense incurred in connection with
the Plan or any Award, nor will such individual be personally liable with respect to the Plan because of any contract or other instrument he or she executes in his or her capacity as an Administrator, director, officer, other employee or agent of
the Company. The Company will indemnify and hold harmless each director, officer, other employee and agent of the Company to whom any duty or power relating to the administration or interpretation of the Plan has been or will be granted or
delegated, against any cost or expense (including attorneys’ fees) or liability (including any sum paid in settlement of a claim with the Administrator’s approval) arising out of any act or omission to act concerning this Plan unless
arising out of such person’s own fraud or bad faith. 
 (h) Lock-Up Period. The Company
may, at the request of any representative of the underwriters or otherwise, in connection with any registration of the offering of any securities of the Company under the Securities Act, prohibit Participants from, directly or indirectly, selling or
otherwise transferring any shares of Common Stock or other securities of the Company during a period of up to one hundred eighty days following the effective date of a registration statement of the Company filed under the Securities Act. 

(i) Right of First Refusal. 

(i) Before any shares of Common Stock held by a Participant or any permitted transferee (each, a “Holder”) may be
sold, pledged, assigned, hypothecated, transferred, or otherwise disposed of (each, a “Transfer”), the Company or its assignee(s) shall have a right of first refusal to purchase the shares of Common Stock proposed to be Transferred on the
terms and conditions set forth in this Section 10(i) (the “Right of First Refusal”). In the event that the Company’s charter, bylaws and/or a stockholders’ agreement applicable to the shares of Common Stock contain a right
of first refusal with respect to the shares of Common Stock, such right of first refusal shall apply to the shares of Common Stock to the extent such provisions are more restrictive than the Right of First Refusal set forth in this
Section 10(i) and the Right of First Refusal set forth in this Section 10(i) shall not in any way restrict the operation of the Company’s charter, bylaws or the operation of any applicable stockholders’ agreement. 

(ii) In the event any Holder desires to Transfer any shares of Common Stock, the Holder shall deliver to the Company a written
notice (the “Notice”) stating: (A) the Holder’s bona fide intention to sell or otherwise Transfer such shares of Common Stock; (B) the name of each proposed purchaser or other transferee (“Proposed Transferee”);
(C) the number of shares of Common Stock to be Transferred to each Proposed Transferee; and (D) the price for which the Holder proposes to Transfer the shares of Common Stock (the “Offered Price”), and the Holder shall offer such
shares of Common Stock at the Offered Price to the Company or its assignee(s). 

  
 12 

 (iii) Within twenty-five days after receipt of the Notice, the Company
and/or its assignee(s) may elect in writing to purchase all, but not less than all, of the shares of Common Stock proposed to be Transferred to any one or more of the Proposed Transferees by delivery of a written exercise notice to the Holder (a
“Company Notice”). The purchase price (“Purchase Price”) for the shares of Common Stock repurchased under this Section 10(i) shall be the Offered Price. 

(iv) Payment of the Purchase Price shall be made, at the option of the Company or its assignee(s), in cash (by check or wire
transfer), by cancellation of all or a portion of any outstanding indebtedness of the Holder to the Company (or, in the case of repurchase by an assignee, to the assignee), or by any combination thereof, within five days after delivery of the
Company Notice or in the manner and at the times mutually agreed to by the Company and the Holder. Should the Offered Price specified in the Notice be payable in property other than cash, the Company or its assignee shall have the right to pay the
purchase price in the form of cash equal in amount to the value of such property, as determined by the Administrator. 
 (v)
If all or a portion of the shares of Common Stock proposed in the Notice to be Transferred are not purchased by the Company and/or its assignee(s) as provided in this Section 10(i), then the Holder may sell or otherwise Transfer such shares of
Common Stock to that Proposed Transferee at the Offered Price or at a higher price; provided that such sale or other Transfer is consummated within sixty days after the date of the Notice; and provided, further, that any such sale or other Transfer
is effected in accordance with any Applicable Laws and the Proposed Transferee agrees in writing that the provisions of this Plan and the applicable Award Agreement and any other applicable agreements governing the shares of Common Stock to be
Transferred shall continue to apply to the shares of Common Stock in the hands of such Proposed Transferee. If the shares of Common Stock described in the Notice are not Transferred to the Proposed Transferee within such sixty-day period, a new Notice shall be given to the Company, and the Company and/or its assignees shall again be offered the Right of First Refusal, as provided herein, before any shares of Common Stock held by the
Holder may be sold or otherwise Transferred. 
 (vi) Anything to the contrary contained in this Section 10(i)
notwithstanding and to the extent permitted by the Administrator, the Transfer of any or all of the shares of Common Stock during a Participant’s lifetime or upon a Participant’s death by will or intestacy to the Participant’s
Immediate Family or a trust for the benefit of the Participant’s Immediate Family shall be exempt from the Right of First Refusal. As used herein, “Immediate Family” shall mean spouse, lineal descendant or antecedent, father, mother,
brother or sister or stepchild (whether or not adopted). In such case, the transferee or other recipient shall receive and hold the shares of Common Stock so Transferred subject to the provisions of this Plan (including the Right of First Refusal),
the applicable Award Agreement and any other applicable agreements governing the shares of Common Stock to be Transferred, and there shall be no further Transfer of such shares of Common Stock except in accordance with the terms of this
Section 1 0(i) (or otherwise as expressly provided under the Plan). 

  
 13 

 (vii) The Right of First Refusal shall terminate as to all shares of Common
Stock if the Company becomes a Publicly Listed Company upon such occurrence. 
 (j) Data Privacy. As a condition of receipt of any
Award, each Participant explicitly and unambiguously consents to the collection, use and transfer, in electronic or other form, of personal data as described in this paragraph by and among, as applicable, the Company and its subsidiaries and
affiliates for the exclusive purpose of implementing, administering and managing the Participant’s participation in the Plan. The Company and its subsidiaries and affiliates may hold certain personal information about a Participant, including
but not limited to, the Participant’s name, home address and telephone number, date of birth, social security or insurance number or other identification number, salary, nationality, job title(s), any shares of stock held in the Company or any
of its subsidiaries and affiliates, details of all Awards, in each case, for the purpose of implementing, managing and administering the Plan and Awards (the “Data”). The Company and its subsidiaries and affiliates may transfer the Data
amongst themselves as necessary for the purpose of implementation, administration and management of a Participant’s participation in the Plan, and the Company and its subsidiaries and affiliates may each further transfer the Data to any third
parties assisting the Company in the implementation, administration and management of the Plan. These recipients may be located in the Participant’s country, or elsewhere, and the Participant’s country may have different data privacy laws
and protections than the recipients’ country. Through acceptance of an Award, each Participant authorizes such recipients to receive, possess, use, retain and transfer the Data, in electronic or other form, for the purposes of implementing,
administering and managing the Participant’s participation in the Plan, including any requisite transfer of such Data as may be required to a broker or other third party with whom the Company or the Participant may elect to deposit any shares
of Common Stock. The Data related to a Participant will be held only as long as is necessary to implement, administer, and manage the Participant’s participation in the Plan. A Participant may, at any time, view the Data held by the Company
with respect to such Participant, request additional information about the storage and processing of the Data with respect to such Participant, recommend any necessary corrections to the Data with respect to the Participant or refuse or withdraw the
consents herein in writing, in any case without cost, by contacting his or her local human resources representative. The Company may cancel Participant’s ability to participate in the Plan and, in the Administrator’s discretion, the
Participant may forfeit any outstanding Awards if the Participant refuses or withdraws his or her consents as described herein. For more information on the consequences of refusal to consent or withdrawal of consent, Participants may contact their
local human resources representative. 
 (k) Severability. In the event any portion of the Plan or any action taken pursuant thereto
shall be held illegal or invalid for any reason, the illegality or invalidity shall not affect the remaining parts of the Plan, and the Plan shall be construed and enforced as if the illegal or invalid provisions had not been included, and the
illegal or invalid action shall be null and void. 
 (l) Governing Documents. In the event of any contradiction between the Plan and
any Award Agreement or any other written agreement between a Participant and the Company or any Subsidiary of the Company that has been approved by the Administrator, the terms of the Plan shall govern, unless it is expressly specified in such Award
Agreement or other written document that a specific provision of the Plan shall not apply. 

  
 14 

 (m) Submission to Jurisdiction; Waiver of Jury Trial. By accepting an Award, each
Participant irrevocably and unconditionally consents to submit to the exclusive jurisdiction of the courts of the State of California and of the United States of America, in each case located in the State of California, for any action arising out of
or relating to the Plan (and agrees not to commence any litigation relating thereto except in such courts), and further agrees that service of any process, summons, notice or document by U.S. registered mail to the address contained in the records
of the Company shall be effective service of process for any litigation brought against it in any such court. By accepting an Award, each Participant irrevocably and unconditionally waives any objection to the laying of venue of any litigation
arising out of Plan or Award hereunder in the courts of the State of California or the United States of America, in each case located in the State of California, and further irrevocably and unconditionally waives and agrees not to plead or claim in
any such court that any such litigation brought in any such court has been brought in an inconvenient forum. By accepting an Award, each Participant irrevocably and unconditionally waives, to the fullest extent permitted by applicable law, any and
all rights to trial by jury in connection with any litigation arising out of or relating to the Plan or any Award hereunder. 
 (n)
Governing Law. The provisions of the Plan and all Awards made hereunder shall be governed by and interpreted in accordance with the laws of the State of California, disregarding
choice-of-law principles of the law of any state that would require the application of the laws of a jurisdiction other than such state. 

(o) Restrictions on Shares; Claw-back Provisions. Shares of Common Stock acquired in respect of Awards shall be subject to such terms
and conditions as the Administrator shall determine, including, without limitation, restrictions on the transferability of shares of Common Stock, the right of the Company to repurchase shares of Common Stock, the right of the Company to require
that shares of Common Stock be transferred in the event of certain transactions, tag-along rights, bring-along rights, redemption and co-sale rights and voting
requirements. Such terms and conditions may be additional to those contained in the Plan and may, as determined by the Administrator, be contained in the applicable Award Agreement or in an exercise notice, stockholders’ agreement or in such
other agreement as the Administrator shall determine, in each case in a form determined by the Administrator. The issuance of such shares of Common Stock shall be conditioned on the Participant’s consent to such terms and conditions and the
Participant’s entering into such agreement or agreements. All Awards (including any proceeds, gains or other economic benefit actually or constructively received by Participant upon any receipt or exercise of any Award or upon the receipt or
resale of any shares of Common Stock underlying the Award) shall be subject to the provisions of any claw-back policy implemented by the Company, including, without limitation, any claw-back policy adopted to comply with the requirements of the
Dodd-Frank Wall Street Reform and Consumer Protection Act and any rules or regulations promulgated thereunder, to the extent set forth in such claw-back policy and/or in the applicable Award Agreement. 

(p) Titles and Headings. The titles and headings of the Sections in the Plan are for convenience of reference only and, in the event of
any conflict, the text of the Plan, rather than such titles or headings, shall control. 
 (q) Conformity to Securities Laws.
Participant acknowledges that the Plan is intended to conform to the extent necessary with all provisions of the Securities Act and the 

  
 15 

 
Exchange Act and any and all regulations and rules promulgated by the Securities and Exchange Commission thereunder, and state securities laws and regulations. Notwithstanding anything herein to
the contrary, the Plan and all Awards granted hereunder shall be administered only in such a manner as to conform to such laws, rules and regulations. To the extent permitted by Applicable Laws, the Plan and all Award Agreements shall be deemed
amended to the extent necessary to conform to such laws, rules and regulations. 
 11. Definitions. As used in the Plan, the
following words and phrases shall have the following meanings: 
 (a) “Administrator” means the Board or a Committee to the
extent that the Board’s powers or authority under the Plan have been delegated to such Committee. 
 (b) “Applicable Laws”
means the requirements relating to the administration of equity incentive plans under U.S. federal and state securities, tax and other applicable laws, rules and regulations, the applicable rules of any stock exchange or quotation system on
which the Common Stock is listed or quoted and the applicable laws and rules of any foreign country or other jurisdiction where Awards are granted or issued under the Plan. 

(c) “Award” means, individually or collectively, a grant under the Plan of Options, Restricted Stock, Restricted Stock Units
or Other Stock-Based Awards. 
 (d) “Award Agreement” means a written agreement evidencing an Award, which agreements may
be in electronic medium and shall contain such terms and conditions with respect to an Award as the Administrator shall determine, consistent with and subject to the terms and conditions of the Plan. 

(e) “Board” means the Board of Directors of the Company. 

(f) “Cause,” with respect to a Participant, means “Cause” (or any term of similar effect) as defined in such
Participant’s employment agreement with the Company if such an agreement exists and contains a definition of Cause (or term of similar effect), or, if no such agreement exists or such agreement does not contain a definition of Cause (or term of
similar effect), then Cause shall include, but not be limited to: (i) the Participant’s unauthorized use or disclosure of confidential information or trade secrets of the Company or any material breach of a written agreement between the
Participant and the Company, including without limitation a material breach of any employment, confidentiality, non-compete, non-solicit or similar agreement;
(ii) the Participant’s commission of, indictment for or the entry of a plea of guilty or nolo contendere by the Participant to, a felony under the laws of the United States or any state thereof or any crime involving dishonesty or moral
turpitude (or any similar crime in any jurisdiction outside the United States); (iii) the Participant’s negligence or willful misconduct in the performance of the Participant’s duties or the Participant’s willful or repeated failure
or refusal to substantially perform assigned duties; (iv) any act of fraud, embezzlement, material misappropriation or dishonesty committed by the Participant against the Company; or (v) any acts, omissions or statements by a Participant
which the Company determines to be materially detrimental or damaging to the reputation, operations, prospects or business relations of the Company. 

  
 16 

 (g) “Change in Control” means (i) a merger or consolidation of the
Company with or into any other corporation or other entity or person, (ii) a sale, lease, exchange or other transfer in one transaction or a series of related transactions of all or substantially all of the Company’s assets, or
(iii) any other transaction, including the sale by the Company of new shares of its capital stock or a transfer of existing shares of capital stock of the Company, the result of which is that a third party that is not an affiliate of the
Company or its stockholders (or a group of third parties not affiliated with the Company or its stockholders) immediately prior to such transaction acquires or holds capital stock of the Company representing a majority of the Company’s
outstanding voting power immediately following such transaction; provided that the following events shall not constitute a “Change in Control”: (A) a transaction (other than a sale of all or substantially all of the Company’s assets)
in which the holders of the voting securities of the Company immediately prior to the merger or consolidation hold, directly or indirectly, at least a majority of the voting securities in the successor corporation or its parent immediately after the
merger or consolidation; (B) a sale, lease, exchange or other transaction in one transaction or a series of related transactions of all or substantially all of the Company’s assets to an affiliate of the Company; (C) an initial public
offering of any of the Company’s securities; (D) a reincorporation of the Company solely to change its jurisdiction; or (E) a transaction undertaken for the primary purpose of creating a holding company that will be owned in
substantially the same proportion by the persons who held the Company’s securities immediately before such transaction. Notwithstanding the foregoing, if a Change in Control would give rise to a payment or settlement event with respect to any
Award that constitutes “nonqualified deferred compensation,” the transaction or event constituting the Change in Control must also constitute a “change in control event” (as defined in Treasury Regulation §1.409A-3(i) (5)) in order to give rise to the payment or settlement event for such Award, to the extent required by Section 409A. 

(h) “Code” means the Internal Revenue Code of 1986, as amended, and the regulations issued thereunder. 

(i) “Committee” means one or more committees or subcommittees of the Board, which may be comprised of one or more directors
and/or executive officers of the Company, in either case, to the extent permitted in accordance with Applicable Laws. 
 (j) “Common
Stock” means the common stock of the Company. 
 (k) “Company” means Cardiva Medical, Inc., a Delaware
corporation, or any successor thereto. Except where the context otherwise requires, the term “Company” includes any of the Company’s present or future parent or subsidiary corporations as defined in Sections 424(e) or (f) of the
Code and any other business venture (including, without limitation, joint venture or limited liability company) in which the Company has a significant interest, as determined by the Administrator. 

(l) “Consultant” means any person, including any advisor, engaged by the Company or a parent or subsidiary of the Company to
render services to such entity if: (i) the consultant or adviser renders bona fide services to the Company; (ii) the services rendered by the consultant or advisor are not in connection with the offer or sale of securities in a
capital-raising transaction and do not directly or indirectly promote or maintain a market for the Company’s securities; and (iii) the consultant or advisor is a natural person, or such other advisor or consultant as is approved by the
Administrator. 

  
 17 

 (m) “Designated Beneficiary” means the beneficiary or beneficiaries
designated, in a manner determined by the Administrator, by a Participant to receive amounts due or exercise rights of the Participant in the event of the Participant’s death or incapacity In the absence of an effective designation by a
Participant, “Designated Beneficiary” shall mean the Participant’s estate. 
 (n) “Director” means a member
of the Board. 
 (o) “Disability” means a permanent and total disability within the meaning of Section 22(e) (3)
of the Code, as it may be amended from time to time. 
 (p) “Dividend Equivalents” means a right granted to a Participant
pursuant to Section 6(d) (3) hereof to receive the equivalent value (in cash or shares of Common Stock) of dividends paid on shares of Common Stock. 

(q) “Effective Date” has the meaning set forth in Section 10(c) hereof. 

(r) “Employee” means any person, including officers and Directors, employed by the Company (within the meaning of
Section 3401(c) of the Code) or any parent or subsidiary of the Company. 
 (s) “Equity Restructuring” means, as
determined by the Administrator, a non-reciprocal transaction between the Company and its stockholders, such as a stock dividend, stock split, spin-off or
recapitalization through a large, nonrecurring cash dividend, that affects the shares of Common Stock (or other securities of the Company) or the share price of Common Stock (or other securities of the Company) and causes a change in the per share
value of the Common Stock underlying outstanding Awards. 
 (t) “Exchange Act” means the Securities Exchange Act of 1934,
as amended. 
 (u) “Fair Market Value” means, as of any date, the value of Stock determined as follows: (i) if the
Common Stock is listed on any established stock exchange, its Fair Market Value shall be the closing sales price for such Common Stock as quoted on such exchange for such date, or if no sale occurred on such date, the first market trading day
immediately prior to such date during which a sale occurred, as reported in The Wall Street Journal or such other source as the Administrator deems reliable; (ii) if the Common Stock is not traded on a stock exchange but is quoted on a national
market or other quotation system, the last sales price on such date, or if no sales occurred on such date, then on the date immediately prior to such date on which sales prices are reported, as reported in The Wall Street Journal or such other
source as the Administrator deems reliable; or (iii) in the absence of an established market for the Common Stock, the Fair Market Value thereof shall be determined by the Administrator in its sole discretion. 

(v) “Incentive Stock Option” means an “incentive stock option” as defined in Section 422 of the Code. 

  
 18 

 (w) “Non-Qualified Stock Option”
means an Option that is not intended to be or otherwise does not qualify as an Incentive Stock Option. 
 (x) “Option”
means an option to purchase Common Stock. 
 (y) “Other Stock-Based Awards” means other Awards of shares of Common
Stock, and other Awards that are valued in whole or in part by reference to, or are otherwise based on, shares of Common Stock or other property. 

(z) “Participant” means a Service Provider who has been granted an Award under the Plan. 

(aa) “Plan” means this Amended and Restated 2014 Equity Incentive Plan. 

(bb) “Prior Plan” means the Cardiva Medical, Inc. 2002 Stock Option Plan, as amended. 

(cc) “Publicly Listed Company” means that the Company or its successor (i) is required to file periodic reports pursuant
to Section 12 of the Exchange Act and (ii) the Common Stock is listed on one or more National Securities Exchanges (within the meaning of the Exchange Act) or is quoted on NASDAQ or a successor quotation system. 

(dd) “Restricted Stock” means Common Stock awarded to a Participant pursuant to Section 6 hereof that is subject to
certain vesting conditions and other restrictions. 
 (ee) “Restricted Stock Unit” means an unfunded, unsecured right to
receive, on the applicable settlement date, one share of Common Stock or an amount in cash or other consideration determined by the Administrator equal to the value thereof as of such payment date, which right may be subject to certain vesting
conditions and other restrictions. 
 (ff) “Section 409A” means Section 409A of the Code and all regulations,
guidance, compliance programs and other interpretative authority thereunder. 
 (gg) “Securities Act” means the Securities
Act of 1933, as amended from time to time. 
 (hh) “Service Provider” means an Employee, Consultant or Director. 

(ii) “Termination of Service” means the date the Participant ceases to be a Service Provider. 

* * * * * 

  
 19 

 CARDIVA MEDICAL, INC. 

AMENDED AND RESTATED 2014 EQUITY INCENTIVE PLAN 

CALIFORNIA SUPPLEMENT 

This supplement is intended to satisfy the requirements of Section 25102(o) of the California Corporations Code and the regulations
issued thereunder (“Section 25102(o)”). Notwithstanding anything to the contrary contained in the Plan and except as otherwise determined by the Administrator, the provisions set forth in this supplement shall apply to all Awards
granted under the Plan to a Participant who is a resident of the State of California on the date of grant (a “California Participant”) and which are intended to be exempt from registration in California pursuant to Section 25102(o),
and otherwise to the extent required to comply with applicable law (but only to such extent). Definitions in the Plan are applicable to this supplement. 

1. Limitation On Securities Issuable Under Plan. The amount of securities issued pursuant to the Plan shall not exceed the amounts permitted under
Section 260.140.45 of the California Code of Regulations to the extent applicable. 
 2. Additional Limitations For Grants. The terms of all
Awards shall comply, to the extent applicable, with Sections 260.140.41 and 260.140.42 of the California Code of Regulations. 
 3. Additional
Requirement To Provide Information To California Participants. The Company shall provide to each California Participant, not less frequently than annually, copies of annual financial statements (which need not be audited). The Company shall not
be required to provide such statements to key persons whose duties in connection with the company assure their access to equivalent information. In addition, this information requirement shall not apply to any plan or agreement that complies with
all conditions of Rule 701 of the Securities Act of 1933, as amended (“Rule 701”); provided that for purposes of determining such compliance, any registered domestic partner shall be considered a “family member” as that term is
defined in Rule 701. 
 * * * * * 

  
 CS-1

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00318-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00318-of-00352.parquet"}]]