Document:

FORM OF CURIS COMMON STOCK CERTIFICATE

 Exhibit 4.1 
  

[FRONT OF CURIS STOCK CERTIFICATE] 
  
 [LOGO] 
 CURIS, INC. 
 INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE 
  

			
	 NUMBER
	 	SHARES
	 	 	SEE REVERSE FOR CERTAIN DEFINITIONS
	 	 	CUSIP 231269 10 1

  
 THIS CERTIFIES THAT 
  
  
  
 is the owner of 
  
 FULLY-PAID AND NON-ASSESSABLE SHARES OF THE COMMON STOCK, PAR VALUE $.01 PER SHARE, OF 
  
 Curis, Inc., transferable upon the books of the corporation in person or by attorney upon surrender of this certificate duly endorsed or assigned. This certificate and
the shares represented hereby are subject to the laws of the State of Delaware and to the Certificate of Incorporation and by-laws of the corporation. This certificate is not valid until countersigned by the Transfer Agent and registered by the
Registrar. 
  
 IN WITNESS WHEREOF, Curis, Inc. has caused its
corporate seal to be hereunto affixed and this certificate to be singed by its duly authorized officers. 
  
 Dated: 
  

					
	 TREASURER
	 	[SEAL]	 	CHIEF EXECUTIVE OFFICER
	 	 	CURIS, INC.	 	 
	 	 	CORPORATE	 	 
	 	 	SEAL	 	 
	 	 	2000	 	 
	 	 	DELAWARE	 	 

  
 COUNTERSIGNED AND REGISTERED:

 MELLON INVESTOR SERVICES LLC 
 TRANSFER AGENT AND REGISTRAR.

  
 BY 
  
 AUTHORIZED SIGNATURE 
  

 [BACK OF CURIS STOCK CERTIFICATE] 
  
 CURIS, INC. 
  
 THE CORPORATION IS AUTHORIZED TO ISSUE MORE THAN ONE CLASS OR SERIES OF STOCK. A COPY OF THE PREFERENCES, POWERS, QUALIFICATIONS AND RIGHTS OF EACH CLASS
AND SERIES WILL BE FURNISHED BY THE CORPORATION UPON WRITTEN REQUEST AND WITHOUT CHARGE. 
  
 The following abbreviations, when used in the in the inscription on the face of this certificate, shall be construed as though they were written out in full according to applicable laws or regulations: 
  

							
	 TEN COM —
	 	as tenants in common	 	UNIF GIFT MIN ACT —	 	                  Custodian
                

	 TEN ENT  —
	 	as tenants by the entireties	 	 	 	   (Cust)                        (Minor)

	 JT TEN      —
	 	as joint tenants with rights of survivorship and not as tenants in common.	 	 	 	 Under Uniform Gifts to Minors

	 	 	 	 	 	   Act
                                       
 

	 	 	 	 	 	(State)    

  
 Additional
abbreviations may also be used though not in the above list. 
  
 For value
received,
                                        
                 hereby sell, assign and transfer unto 
  
 PLEASE INSERT SOCIAL SECURITY OR OTHER 
 IDENTIFYING NUMBER OF ASSIGNEE

  
                                       
                                        
                                        
                                        
                                        
             
 PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS INCLUDING ZIP CODE OF ASSIGNEE

  
                                       
                                        
                                        
                                        
                                        
             
  
                                       
                                        
                                        
                                        
                                        
             
  
                                       
                                        
                                        
                                        
                                        
             
 Shares of the Capital Stock represented by the within Certificate, and do
hereby irrevocably constitute and appoint 
  
                                       
                                        
                                        
                                        
                                        
             
 Attorney to transfer the said stock on the books of the within-named
Corporation with full power of substitution in the premises. 
  
 Dated
                                 
  

			
	

	NOTICE:	 	THE SIGNATURE TO THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME AS WRITTEN UPON THE FACE OF THE CERTIFICATE, IN EVERY PARTICULAR, WITHOUT ALTERATION OR ENLARGEMENT, OR ANY CHANGE
WHATEVER.

  

											
			
	Signature(s) Guaranteed:	 	  

	 	 
	 	 	THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS, AND CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED
SIGNATURE GUARANTEE MEDALLION PROGRAM), PURSUANT TO S.E.C. RULE 17Ad-15.AMENDMENT TO THE EMPLOYMENT AGREEMENT W/ CHRISTOPHER U. MISSLING

 Exhibit 10.3 
  
 Amendment to Employment Agreement (“Amendment”) 
  
 This Amendment to the Employment Agreement (“Agreement”), dated August 1, 2002, between Curis, Inc. (“Curis”) and
Christopher U. Missling (“Employee”), is made as of the 1st day of January, 2004 (the “Effective
Date”). 
  
 In consideration of the mutual promises and agreements described
in this Amendment and in the Agreement, the parties agree as follows: 
  
 1. The
provisions of Section 1 of the Agreement are deleted in their entirety and amended to read: 
  
 Term of Employment. The Company hereby agrees to employ the Employee, and the Employee hereby accepts employment with the Company, upon the terms set forth in this Agreement, for the period commencing on August
1, 2002 (the “Commencement Date”) and ending on June 30, 2004 (such period, as it may be extended upon mutual agreement of the parties, the “Employment Period”), unless sooner terminated in accordance with the provisions of
Section 4. 
  
 2. The provisions Section 2 of the Agreement are deleted in their
entirety and amended to read: 
  
 Position. 
  

	 	(i)	The Employee shall serve as Senior Vice President, Strategic Analysis and Planning of the Company. The Employee shall have duties and authority consistent with his position as
Senior Vice President, Finance and Strategic Planning as assigned by the President and Chief Executive Officer (the “President”) and the Board of Directors of the Company (the “Board”). 

  

	 	(ii)	The Employee shall report to, and be subject to the supervision of, the President and the Board. The Employee agrees to devote his entire business time to the business and interest
of the Company during the Employment Period. 

  

	 	(iii)	The Employee agrees to abide by the rules, regulations, instructions, personnel practices and policies of the Company and any changes therein which may be adopted from time to time
by the Company. 

  

 3. The provisions of Section 3.2 of the Agreement are deleted in their entirety since they are not applicable, it being
understood and agreed to that as a result of this Amendment the Employee is not entitled to any bonuses whatsoever. Section 3.2 shall be amended to read: 
  
 3.2 [Intentionally omitted.] 
  
 4. The last sentence of Section 3.6 is deleted in its entirety. It being understood and agreed to that as a result of this Amendment, the Company will not reimburse
Employee for any tax preparation costs whatsoever. 
  
 5. The provisions of
Section 4 of the Agreement are deleted in their entirety and amended to read: 
  
 Termination of Employment Period. 
  
 (a) The employment of the Employee by the Company pursuant to this Agreement shall terminate upon the expiration of the Employment Period. 
  
 (b) The Company has the right to terminate the Employee’s employment under this Agreement upon verbal notice to the
Employee at any time in the event Employee is not performing his assigned duties or is engaging in activities that are harmful to Company it being understood that such determination shall be at the Company’s sole discretion. Any such
termination shall be effective upon such notice to the Employee.  
  
 (c) The Employee has the right to terminate his employment under this Agreement upon verbal notice to the Company at any time for any reason or no reason. Any such termination shall be effective upon such notice to
the Employee. 
  
 (d) In the event that Company or Employee
terminates the employment relationship before June 30, 2004, Company will pay the Employee the balance of his salary through June 30, 2004. 
  
 6. The provisions of Section 6 of the Agreement are deleted in their entirety since they are not applicable, it being understood and agreed to that as a result of this
Amendment the Employee is not entitled to any severance payments upon the termination of his employment with the Company for whatever reason and that the Company shall have no obligations to make severance payments to Employee under the terms of the
Agreement. Section 6 is amended to read: 
  
 Section 6.
[Intentionally omitted.] 
  

 7. The provisions of the first paragraph in Section 7 of the Agreement are deleted in their entirety and amended to read:

  
 Notices. All notices, instructions, demands, claims,
requests and other communications given hereunder or in connection herewith shall be in writing, except as expressly provided for elsewhere in the Agreement. Any such communication shall be sent either (a) by registered or certified mail, return
receipt requested, postage prepaid, or (b) via a reputable nationwide overnight courier service, in each case to the address set forth below. Any such communication shall be deemed to have been delivered two business days after it is sent by
registered or certified mail return receipt requested, postage prepaid, or one business day after it is sent via a reputable nationwide overnight courier service. 
  
 8. All other terms and conditions of the Agreement shall remain the same. 
  
 IN WITNESS WHEREOF, the parties hereto have executed this Amendment as of the Effective Date. 
  

			
	CURIS, Inc.
		
	By:	 	/s/    DANIEL R. PASSERI        
	 	 	

	 Name:
	 	Daniel R. Passeri
	 Title:
	 	President and Chief Executive Officer

  

	
	EMPLOYEE
	
	/s/    CHRISTOPHER U. MISSLINGEMPLOYMENT AGREEMENT W/ MICHAEL P. GRAY

 Exhibit 10.4 
  
 December 10, 2003 
  
 Michael P. Gray 
 57 Lancaster Road 
 Sudbury, MA 01776 
  
 Dear Mike, 
  
 I am pleased to confirm your
promotion. This letter will outline the new terms and benefits of your employment with Curis, Inc., and will supercede the previous letter concerning your terms of employment dated January 26, 1998. 
  
 Position: Vice President, Chief Financial Officer 
  
 Reporting to: Dan Passeri, President and CEO 
  
 Effective Date: November 27, 2003 
  
 Rate of Pay: $15,416.70 per month to be reviewed as part of our performance review
program. It is understood that paychecks will be issued on alternating Fridays. 
  
 Work Week: You will generally work Monday through Friday, at least 40 hours per week. 
  
 Benefits: You will be provided fully paid D & O insurance. 
  
 Stock Options: You will be recommended for an option to purchase 160,000 shares of Curis common stock, to be awarded by the Board of Directors at the next Board Meeting or Compensation Committee meeting
following your start date. The shares will be awarded at a price to be determined by the Board of Directors and will vest over four years, 25% after the first year and 6.25% per quarter over the remainder of the vesting period. Vesting of stock
options is contingent upon your continued employment at Curis. The award will be subject to and governed by the terms and conditions of an agreement between you and the Curis and the Curis Inc. 2000 Stock Incentive Plan (the “Plan”).

  
 It should be understood by you that your employment at Curis, Inc. is at all
times on an “at will” basis, which means that it is not guaranteed for any specified period of time and may be terminated by you or by Curis at any time, with or without notice, and regardless of the date of payment of your salary. By
accepting the terms of this agreement, you acknowledge and agree that no contrary representation has been made to you. This at-will employment 

  

 Michael P. Gray 
  

 
relationship will remain in effect throughout your employment with Curis. It may not be modified by an oral or implied agreement. The terms of your
employment will be interpreted in accordance with and governed by the laws of The Commonwealth of Massachusetts. 
  
 It is anticipated that you will continue your employment with Curis, Inc. for at least four years. In the event your employment with the Company is involuntarily
terminated by the Company without cause, the Company will continue to pay you as severance benefits your base salary as in effect on the date of your employment with the Company, to the extent that such benefits can be provided to non-employees, for
six months provided you execute a separation agreement and release prepared by and satisfactory to the Company and such agreement becomes binding. 
  
 Cause means (a) your failure or refusal to substantially perform your duties or your continued neglect to perform such duties to the full extent of your abilities for
reasons other than death, physical or mental incapacity, (b) a good faith finding by the Company of your failure to perform your duties as assigned to you by the Board of Directors or Chief Executive Officer of the Company, (c) a good faith finding
by the Company of dishonesty, gross negligence, or misconduct, (d) conviction or the entry of a pleading of nolo contender e to any crime or felony, or (e) any breach or threatened breach of any confidentiality, non-solicitation, or
inventions agreement with the Company. 
  
 If the terms of this employment
agreement are acceptable, please indicate your acceptance by signing both copies of this letter. Please return one copy of each to Kristie Haskell, Director, Human Resources. 
  

	
	 Sincerely,

	
	/s/    DANIEL R. PASSERI        
	

	Dan Passeri
	President and CEO
	
	 Agreed and accepted:

	
	/s/    MICHAEL P. GRAY        
	

	Michael P. Gray
	
	 Date: 12/15/03

  
 Enclosures 
  
 Invention, Non-Disclosure and Non-Competition Agreement 
  
 Form I-9 
  

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