Document:

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                                                                    EXHIBIT 10.3

                     AGREEMENT BETWEEN OWNER AND CONTRACTOR

     THIS AGREEMENT between Owner and Contractor (the "Agreement") is entered
into as of the 25th day of April, 2002 by and between Millennium
Pharmaceuticals, Inc. ("Owner") and Walsh Brothers Incorporated ("Contractor").

     WHEREAS, FC 40 Landsdowne, Inc. ("Landlord") and Owner as "tenant" are
parties to a certain lease (the "Lease") of premises located at 40 Landsdowne
Street, Cambridge, Massachusetts;

     WHEREAS, pursuant to the Lease, Landlord is developing an office and
laboratory building (the "Building") of which Tenant will be the sole tenant;

     WHEREAS, Landlord has entered into a contract with Contractor dated
November 16, 2001 (the "Owner/Contractor Contract") (in the form attached hereto
as Exhibit I) to provide construction services for the base building work at the
Building (the "Base Building Work");

     WHEREAS, Owner desires to engage the Contractor to provide construction
services for the Project, described below, being work not included in the Base
Building Work (the "Tenant Work");

     WHEREAS, the Lease requires that Tenant's contract with the Contractor be
in substantially the same form as the Landlord/Contractor Contract; and

     WHEREAS, the parties intend that the terms of the Landlord/Contractor
Contract be incorporated into this Agreement, except as modified by the terms
below, which shall take precedence over and supercede any and all inconsistent
provisions of the Landlord/Contractor Contract;

     NOW, THEREFORE, Owner and Contractor agree as follows:

     The parties agree to be bound by a contract on the terms and conditions of
the Owner/Contractor Contract, except as particular Sections and other items
therein are modified as set forth below, each heading below referring to a
Section or item of the Owner/Contractor Contract to be modified.

Owner:                          All references to Owner shall mean:

                                Millennium Pharmaceuticals, Inc.
                                75 Sidney Street
                                Cambridge, Massachusetts 02139 (herein called
                                "Owner" or "Tenant")

Project:                        The project governed by this Agreement shall be
                                Tenant Work, including all interior systems, for
                                office and laboratory space within cold core
                                shell building located at 40 Landsdowne Street.

Section 4.1:                    Delete "June 21, 2001" and replace with
                                "October 3, 2001".

Section 4.2:                    Delete "September 23, 2002" and replace with
                                "June 10, 2003".

Section 5.1:                    Delete "Eight hundred twelve thousand five
                                hundred dollars ($812,500)" and replace with
                                "One million two hundred thousand twenty-eight
                                dollars ($1,200,028)".

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                                Delete the last sentence and replace with "For
                                changes in the Work that increase the Cost of
                                the Work in the aggregate, the Contractor's
                                compensation shall be increased by an amount
                                equal to three percent (3%) of the amount of the
                                direct net (i.e., taking into account the net
                                effect of changes in the Work decreasing the
                                Cost of the Work and changes in the Work
                                increasing the cost of the Work) direct increase
                                in the Cost of the Work."

Section 5.2.1:                  Delete "Twenty-six million one hundred thirty
                                four thousand and six dollars ($26,134,006)" and
                                replace with "Forty-one million five hundred
                                forty-five thousand three hundred eighty-five
                                dollars ($41,545,385)".

Section 7.3.1:                  Delete "five hundred twenty four thousand one
                                hundred fifteen dollars ($524,115)" and replace
                                with "One million four hundred seventeen
                                thousand one hundred fifty-five dollars
                                ($1,417,155)".

Section 12.2:                   Delete "or as follows."

Article 14:                     After Section 14.3.6, the following Sections are
                                hereby inserted:

                                "14.4 During the course of the performance of
                                the Work, Contractor may be given or observe
                                certain trade secrets, technical know-how and
                                other confidential information of Owner and its
                                affiliates ("Confidential Information").
                                Contractor agrees: (i) to hold all such
                                Confidential Information in confidence; (ii) not
                                to disclose such Confidential Information to
                                others; and (iii) not to use such Confidential
                                Information for any purpose other than the
                                performance of Work under this Agreement.
                                Contractor agrees to limit dissemination of and
                                access to such Confidential Information to those
                                individuals in the Contractor's organization who
                                have a need to know such Confidential
                                Information for the above-described purpose.
                                Should Contractor or any member of the
                                Contractor's organization conceive any invention
                                as a result of receiving or observing such
                                information, Contractor agrees to assign or have
                                assigned that invention to Owner. Contractor
                                recognizes that Owner's facilities are private
                                and Contractor will abide by Owner's security
                                requirements and conditions for facilities
                                access and usage and agrees that only those
                                subjects, areas and programs designated by Owner
                                as necessary to fulfill Owner's requirements
                                will be accessed and/or perused by Contractor or
                                any individuals in the Contractor's
                                organization. In no event will any programs or
                                information be copied or removed without Owner's
                                express written approval.

                                14.5 Contractor or any tier subcontractor shall
                                neither hire any employee or officer of Owner
                                while that employee or officer is an employee or
                                officer of Owner, nor pay any salaries,
                                commissions, fees or make any payments or
                                rebates to any employee or officer of Owner, or
                                to any designee of any such employee or officer,
                                nor favor any employee or officer of Owner, or
                                any designee of any such employee or officer
                                with gifts or entertainment of significant cost
                                or value, or with services or goods sold at less
                                than full market value.

                                        2
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                                14.6 Contractor shall work with the Landlord and
                                Owner to coordinate the management,
                                administration and scheduling of the Base
                                Building Work and the Tenant Work. Such
                                cooperation shall include, without limitation,
                                coordination of schedules, regular meetings,
                                generally to be held weekly, during the
                                construction period."

Section 16.1.2:                 Delete the phrase beginning "all as contained"
                                and ending with __/__/2001" and replace with
                                "forming part of this Agreement and bound
                                herewith, and subject to the modifications
                                thereto set forth below".

Schedules A-1, A-2, B, C, D,    Delete and replace with the attached Schedules
E, F, G, H, I, J, and K:        A-1, A-2, B, C, D, E, F, G, H, I, J and K,
                                respectively.

Exhibits A, B and C:            Replace each time it appears "FC 40 Landsdowne,
                                Inc." with "Millennium Pharmaceuticals, Inc."

Exhibits D and E:               Although Landlord is not the "Owner" under this
                                Agreement, the provisions of these Exhibits
                                remain applicable. It is acknowledged, however,
                                that except as may be otherwise provided in the
                                Lease, any and all discretion and rights under
                                these Exhibits to be exercised by the Owner
                                shall be exercised by Millennium
                                Pharmaceuticals, Inc.

     In addition to the foregoing, the following modifications are made to the
General Conditions:

Section 1.2.12:                 After the phrase "performed by others" insert
                                "or the Base Building Work."

Section 2.1.2.1:                Delete "Peter Calkins and Allison Nichols, who
                                shall each" and replace with "Paul Pratt, who
                                shall".

Section 3.5.1:                  Delete the last two sentences and replace with:
                                "As used herein the term Collective Completion
                                means the substantial completion of all work
                                under the Contract Documents and all work under
                                the Owner/Contractor Contract."

Section 3.10.1:                 Replace "Schedule A" with "Schedule A-l".

Section 3.13.1:                 At the end of this Section, insert the
                                following: "The Contractor shall coordinate
                                construction access as required to perform the
                                work under this Agreement, with the
                                Owner/Contractor Contract".

Section 4.4.2:                  Replace "Allison Nichols" with "Paul Pratt."

Section 4.4.3:                  Replace "Allison Nichols" with "Paul Pratt".

                                Replace "Gayle Farris" with "Glenn Batchelder".

Section 4.5.4:                  Replace "Peter Calkins" with "Paul Pratt".

Section 9.8.1:                  Delete "one hundred thousand dollars ($100,000)"
                                and replace the same with "four hundred thousand
                                dollars ($400,000)".

                                Delete "thirty (30)" and replace the same with
                                "ninety (90)".

                                        3
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                                Delete each time it appears the phrase "other
                                than the Deferred Work." In clause (c) of the
                                first sentence replace "Owner's tenants" with
                                "Owner" and "such tenants"' with "Owner's". Add
                                at end of the first sentence: "and (f) the
                                Certificate of Occupancy has been issued by the
                                City of Cambridge". However, this requirement
                                shall be limited to only those issues that are
                                in the control of the Contractor. Delete the
                                last two sentences.

Section 11.4.1:                 Insert the following at the end of this Section:
                                "Notwithstanding the foregoing, to the extent
                                that any such bonds are specified on Schedule B
                                of the Contract, the Guaranteed Maximum Price
                                shall not be increased on account of the cost of
                                such bonds."

Section 13.2.1:                 At the end of this Section, insert the
                                following: "Notwithstanding the foregoing, Owner
                                shall have the right to assign this Agreement to
                                any entity controlling, controlled by or under
                                common control with Owner, any entity that is
                                the successor by merger to Owner or any entity
                                acquiring all or substantially all of the stock
                                or assets of Owner. Without limiting the
                                foregoing, after Substantial Completion, the
                                Owner's rights under this Agreement may be
                                assigned to a successor to or assignee of
                                Owner's interest as tenant under the Lease."

Section 13.3.1:                 Delete "Gayle B. Farris, with a copy to James
                                Ratner, Forest City Rental Properties, 1100
                                Terminal Tower, Cleveland, OH 44115" and replace
                                with "Paul Pratt, with a copy to Pat Gallagher,
                                Hanscomb, Inc., c/o Millennium Pharmaceuticals,
                                Inc., 75 Sidney Street, Cambridge, MA 02139, and
                                to Joel Goldberg, Esq., at the Owner's address
                                included at the beginning of the Agreement."

Exhibit A:                      Delete the Standard Form of Agreement Between
                                Contractor and Subcontractor (but not the
                                attachments and exhibits thereto) and replace
                                the same with the attached Exhibit A.

Exhibit A:                      On the "List of Additional Insured" forming a
                                portion of Exhibit B 1 to Exhibit A, replace
                                "Millennium Pharmaceuticals" with "Millennium
                                Pharmaceuticals, Inc."

                                In Section 4 of Exhibit C to Exhibit A, replace
                                "EXHIBIT D" with "EXHIBIT A."

Exhibit C, Section 10(a):       Replace "$25,000,000 on a per project basis"
                                with "$35,000,000 on a per occurrence annual
                                aggregate basis."

Exhibit C, Section 10(a)(i):    Replace "on a per location basis" with "on a per
                                project aggregate basis."

Exhibit C, Section 10(d):       Delete Section 10(d) in its entirety.

Exhibit C, Section 12:          Replace number (8) of this Section with the
                                following:

                                "(8)   Millennium Pharmaceuticals, Inc.
                                       75 Sidney Street
                                       Cambridge, MA  02139"

                                Add the following to the end of this Section:

                                        4
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                                "(11)  Hanscomb, Inc.
                                       2067 Massachusetts Avenue
                                       Cambridge, MA 02140"

Exhibit C, Section 13:          Replace the name of the certificate holder set
                                forth in this Section with Millennium
                                Pharmaceuticals, Inc., 75 Sidney Street,
                                Cambridge, MA 02139

Exhibit C, Section 15:          Insert at the beginning of this paragraph, "The
                                Landlord, on behalf of".

                                Insert at the end of this paragraph the
                                following: "Such insurance shall cover the Base
                                Building Work and the Tenant Work. The cost of
                                such insurance shall be allocated between
                                Landlord and Owner in the manner set forth in
                                Section 7.4 of the lease between Landlord and
                                Owner."

Exhibit C, Section 16:          Replace "EXHIBIT D" with "EXHIBIT A".

Schedule 1:                     Delete this Schedule

                                        5
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     This Agreement is executed as a sealed instrument as of the date first
above written.

                                        OWNER:

                                        Millennium Pharmaceuticals, Inc.

                                        By:    /s/ Glenn Batchelder
                                           -------------------------------------
                                               Name:  Glenn Batchelder
                                               Title: VP, Operations

                                        CONTRACTOR:

                                        Walsh Brothers Incorporated

                                        By:    /s/ Jeffrey J. Corcoran
                                           -------------------------------------
                                               Name:  Jeffrey J. Corcoran
                                               Title: Vice President

                                        6
<Page>

                       STANDARD FORM OF AGREEMENT BETWEEN
               OWNER AND CONTRACTOR WHERE THE BASIS OF PAYMENT IS
                     THE COST OF THE WORK PLUS A FEE WITH OR
                       WITHOUT A GUARANTEED MAXIMUM PRICE

                      AIA DOCUMENT A111 - ELECTRONIC FORMAT

THIS DOCUMENT HAS IMPORTANT LEGAL CONSEQUENCES: CONSULTATION WITH AN ATTORNEY IS
ENCOURAGED WITH RESPECT TO ITS COMPLETION OR MODIFICATION. AUTHENTICATION OF
THIS ELECTRONICALLY DRAFTED AIA DOCUMENT MAY BE MADE BY USING AIA DOCUMENT D401.

The 1987 Edition of AIA Document A201, General Conditions of the Contract for
Construction, is adopted in this document by reference. Do not use with other
general conditions unless this document is modified. This document has been
approved and endorsed by The Associated General Contractors of America.

Copyright 1920, 1925, 1951, 1958, 1961, 1967, 1974, 1978, 1987 by The American
Institute of Architects, 1735 New York Avenue N.W., Washington D.C. 20006-5292.
Reproduction of the material herein or substantial quotation of its provisions
without written permission of the AIA violates the copyright laws of the United
States and will be subject to legal prosecution.

AGREEMENT

made as of the 16th day of November in the year of Two Thousand One and is
effective as of the 21st day of June in the year Two Thousand One

BETWEEN the Owner:
(NAME AND ADDRESS)

FC 40 Landsdowne, Inc.
c/o Forest City Commercial Group, Inc.
38 Sidney Street
Cambridge, MA 02199

and the Contractor:
(NAME AND ADDRESS)

Walsh Brothers Incorporated
150 Hampshire Street
Cambridge, MA 02139

the Project is:
(NAME AND ADDRESS)

     40 Landsdowne Street
     Cambridge, MA

the Architect is:
(NAME AND ADDRESS)

Elkus/Manfredi Architects Ltd.
530 Atlantic Avenue
Boston, MA 02210

The Owner and Contractor agree as set forth below.

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                                    ARTICLE 1
                             THE CONTRACT DOCUMENTS

1.1       The Contract Documents consist of this Agreement, Conditions of the
Contract (General, Supplementary and other Conditions), Drawings,
Specifications, Addenda issued prior to execution of this Agreement, other
documents listed in this Agreement and Modifications issued after execution of
this Agreement; these form the Contract, and are as fully a part of the Contract
as if attached to this Agreement or repeated herein. The Contract represents the
entire and integrated agreement between the parties hereto and supersedes prior
negotiations, representations or agreements, either written or oral. An
enumeration of the Contract Documents, other than Modifications, appears in
Article 16. If anything in the other Contract Documents is inconsistent with
this Agreement, this Agreement shall govern.

                                    ARTICLE 2
                            THE WORK OF THIS CONTRACT

2.1       The Contractor shall execute the entire Work described in the Contract
Documents, except to the extent specifically indicated in the Contract Documents
to be the responsibility of others.

                                    ARTICLE 3
                           RELATIONSHIP OF THE PARTIES

3.1       The Contractor accepts the relationship of trust and confidence
established by this Agreement and covenants with the Owner to cooperate with the
Architect and utilize the Contractor's best skill, efforts and judgment in
furthering the interests of the Owner; to furnish efficient business
administration and supervision; to make best efforts to furnish at all times an
adequate supply of workers and materials; and to perform the Work in the best
way and most expeditious and economical manner consistent with the interests of
the Owner. The Owner agrees to exercise best efforts to enable the Contractor to
perform the Work in the best way and most expeditious manner by furnishing and
approving in a timely way information required by the Contractor and making
payments to the Contractor in accordance with requirements of the Contract
Documents.

3.2       The Contractor acknowledges that the Owner's desired approach to the
design and construction of the Project is for the Architect, the Owner and the
Contractor to work cooperatively toward the express objectives of (a) designing
a Project that can be constructed in accordance with the Construction Documents,
without the need for significant changes or corrections during the construction
phase, (b) designing and constructing a Project that, upon completion of the
Work, will be complete, ready for operation and suitable for the Owner's
intended use, (c) meeting the Owner's schedule for completion of the Project,
and (d) meeting the Construction budget requirements. The Contractor shall
endeavor, in the performance of the services covered by this Agreement, to act
in a manner consistent with the Owner's desired approach and express objectives.

                                    ARTICLE 4
                 DATE OF COMMENCEMENT AND SUBSTANTIAL COMPLETION

4.1       The date of commencement was June 21, 2001 (INSERT THE DATE OF
COMMENCEMENT, IF IT DIFFERS FROM THE DATE OF THIS AGREEMENT OR, IF APPLICABLE,
STATE THAT THE DATE WILL BE FIXED IN A NOTICE TO PROCEED.)

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4.2       The Contractor shall perform the Work in accordance with the
construction schedule attached hereto as SCHEDULE A-1 (the "Construction
Schedule"), and shall achieve Substantial Completion of the entire Work not
later than

(INSERT THE CALENDAR DATE OR NUMBER OF CALENDAR DAYS AFTER THE DATE OF
COMMENCEMENT. ALSO INSERT ANY REQUIREMENTS FOR EARLIER SUBSTANTIAL COMPLETION OF
CERTAIN PORTIONS OF THE WORK, IF NOT STATED ELSEWHERE IN THE CONTRACT
DOCUMENTS.) [INSERT]

               September 23, 2002
, subject to adjustments of this Contract Time as provided in the Contract
Documents.
(INSERT PROVISIONS, IF ANY, FOR LIQUIDATED DAMAGES RELATING TO FAILURE TO
COMPLETE ON TIME.)
SCHEDULE A-2 attached hereto sets forth dates that are critical in ensuring the
timely and orderly completion of the Work in accordance with the requirements of
the Contract Documents (hereinafter referred to as "Milestone Dates"). The
Construction Schedule and the Milestone Dates may be adjusted pursuant to
Paragraph 8.3 of the General Conditions of the Contract.

                                    ARTICLE 5
                                  CONTRACT SUM

5.1       The Owner shall pay the Contractor in current funds for the
Contractor's performance of the Contract the Contract Sum consisting of the Cost
of the Work as defined in Article 7 and the Contractor's Fee
(STATE A LUMP SUM, PERCENTAGE OF COST OF THE WORK OR OTHER PROVISION FOR
DETERMINING THE CONTRACTOR'S FEE, AND EXPLAIN HOW THE CONTRACTOR'S FEE IS TO BE
ADJUSTED FOR CHANGES IN THE WORK.)

in the lump sum amount of Eight hundred twelve thousand five hundred dollars
($812,500). Notwithstanding anything to the contrary, there shall be no
adjustment in the Contractor's Fee for changes in the Work.

5.2       GUARANTEED MAXIMUM PRICE (IF APPLICABLE)

5.2.1     The sum of the Cost of the Work and the Contractor's Fee is guaranteed
by the Contractor not to exceed Twenty six million one hundred thirty four
thousand and six Dollars ($26,134,006) ($), subject to additions and deductions
by Change Order as provided in the Contract Documents. Such maximum sum is
referred to in the Contract Documents as the Guaranteed Maximum Price. Costs
which would cause the Guaranteed Maximum Price to be exceeded shall be paid by
the Contractor without reimbursement by the Owner.

5.2.1.1   A detailed, line-item breakdown of the Guaranteed Maximum Price,
including the Cost of the Work and the Contractor's Fee (the "GMP Breakdown"),
is attached hereto and incorporated herein as SCHEDULE B.

5.2.1.2   The Owner shall be entitled to the "Guaranteed Maximum Price Savings"
(as such term is defined below). As of the date of final completion of the Work
the amount, if any, by which (x) exceeds (y) shall be considered the "Guaranteed
Maximum Price Savings," where (x) is the Guaranteed Maximum Price (as adjusted
from time to time through Change Orders) and (y) is the sum of the actual Cost
of the Work and the Contractor's Fee.

5.2.1.3   The Guaranteed Maximum Price is subject to the Qualifications and
Assumptions attached hereto and made a part hereof as SCHEDULE C.

5.2.1.4   The Drawings and Specifications upon which the Guaranteed Maximum
Price is based are as listed and described in SCHEDULE D attached hereto and
made a part hereof. (INSERT SPECIFIC PROVISIONS IF THE CONTRACTOR IS TO
PARTICIPATE IN ANY SAVINGS.)

5.2.2     By executing this Agreement, the Contractor represents that the
Drawings and Specifications listed in SCHEDULE D describe the scope,
construction requirements and design intent of the Work in sufficient detail to
enable the Contractor to establish firmly the Guaranteed Maximum Price, subject
to the Qualifications and

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Assumptions. The Contractor shall not be permitted to claim any adjustment in
the Guaranteed Maximum Price in connection with Drawings and Specifications
issued subsequent to the date of this Agreement, except in connection with Scope
Changes as described in subparagraphs 5.2.2.1 through 5.2.2.3.

5.2.2.1   Subsequent to execution of this Agreement, the Architect may issue
additional Drawings and Specifications for portions of the Work and will issue
supplemental instructions, sketches and other materials intended to clarify the
Drawings and Specifications and/or provide details regarding the construction or
design of various parts of the Work (collectively, the "Supplemental Drawings
and Specifications"). The Contractor shall review all Supplemental Drawings and
Specifications in detail and shall, within fifteen (15) days of receiving any
Supplemental Drawings and Specifications, notify the Owner and the Architect of
any error, inconsistency or discrepancy that the Contractor discovers between
the Supplemental Drawings and Specifications and the Drawings and Specifications
listed in SCHEDULE D to this Agreement. Within such fifteen (15) day period the
Contractor shall also notify the Owner in writing of any item which, in the
Contractor's opinion, represents a Scope Change, as defined in subparagraph
5.2.2.2 below, setting forth, with particularity, the reasons the Contractor
contends such item represents a Scope Change (such notice shall constitute a
"Scope Change Request"). A Scope Change Request shall set forth the Contractor's
preliminary estimates of the increased costs and the impacts on the Construction
Schedule, if any, that the Contractor attributes to the Work covered by such
Scope Change Request. Failure of the Contractor to notify the Owner of any item
the Contractor considers a Scope Change within fifteen (15) days after the date
of receipt by the Contractor of Supplemental Drawings and Specifications is
hereby deemed to mean: (1) such Supplemental Drawings and Specifications are
consistent with the Drawings and Specifications listed in SCHEDULE D to this
Agreement; (2) no Scope Changes exist; and (3) the Contractor is willing and
able to perform all of the Work for the Guaranteed Maximum Price and in
accordance with all the requirements of the Contract Documents. The Contractor
shall, within thirty (30) days of receipt of any Supplemental Drawings and
Specifications that contain an item or items the Contractor considers to require
a Scope Change, prepare and provide to the Owner a detailed breakdown of the
proposed increase in the Guaranteed Maximum Price and the proposed changes to
the Construction Schedule and Milestone Dates, if any related to such Scope
Change.

5.2.2.2   A "Scope Change" is hereby deemed to mean Work described in the
Supplemental Drawings and Specifications which is not reasonably inferable from
the Drawings and Specifications listed in SCHEDULE D to this Agreement and is
either (i) materially inconsistent with the Qualifications and Assumptions or
(ii) constitutes a change in the quantity, quality, programmatic requirements or
other substantial deviation from the Drawings and Specifications listed in
SCHEDULE D to this Agreement.

5.2.2.3   If the Contractor timely submits a Scope Change Request to the Owner
in accordance with the requirements of subparagraph 5.2.2.1, the Owner shall
have one or more of the following options:

(1) within ten (10) days of receipt of the Scope Change Request, the Owner shall
direct the Architect in writing, with a copy of such directive to the
Contractor, to modify that aspect of the Supplemental Drawings and
Specifications to which the Contractor objects. The Contractor shall cooperate
with the Owner and the Architect during the modification effort and shall make
recommendations appropriate to correct such portions of the Supplemental
Drawings and Specifications. The Architect shall submit to the Contractor the
revised Supplemental Drawings and Specifications as approved by the Owner. The
Contractor shall promptly re-examine such revised Supplemental Drawings and
Specifications as described in subparagraph 5.2.2.1;

(2) if, upon review of the Scope Change Request, the Owner after consultation
with the Architect) believes that the portion of the Work described therein does
not constitute a Scope Change, the Owner shall so advise the Contractor within
ten (10) days of receipt of the Scope Change Request. If such disagreement is
not resolved, the Work subject to disagreement shall be identified in a schedule
the "Disputed Work Schedule"). Whenever possible, the Owner and the Contractor
shall resolve items set forth in the Disputed Work Schedule, confirming such
resolution in Change Orders. Items in the Disputed Work Schedule that are not
resolved by the Owner and the Contractor shall be subject to the dispute
resolution procedures set forth in Article 4 of the General Conditions. During
the pendency of such dispute resolution procedures, all items remaining in the
Disputed Work Schedule shall be performed by the Contractor as required by the
Contract Documents and a tentative adjustment shall be made to the Guaranteed

<Page>

Maximum Price in the amount of the undisputed portion of the Scope Change
Request. No adjustment shall be made to the Guaranteed Maximum Price for
disputed portions of the Scope Change Request. For each remaining item in the
Disputed Work Schedule, the Contractor shall keep a specific, detailed
accounting of the time and materials required to complete such item. Adjustments
to the Construction Schedule shall not be permitted on a tentative basis;

(3) if, upon review of the Scope Change Request, the Owner agrees that all or a
portion of the Work therein constitutes a Scope Change and the Owner elects not
to direct the Architect to modify the Supplemental Drawings and Specifications,
the Owner and the Contractor shall enter into a written agreement providing for
changes to the Guaranteed Maximum Price and Construction Schedule;

(4) if, with respect to an item in the Scope Change Request, the Owner does not,
within the appropriate time limitations, (a) direct the Architect to modify the
Supplemental Drawings and Specifications, (b) advise the Contractor in writing
of disapproval of such item in the Scope Change Request, or (c) agree that such
item represents a Scope Change, then the Scope Change Request with respect to
such item shall be deemed approved by the Owner and the Guaranteed Maximum Price
and the Construction Schedule shall be modified as requested by the Contractor.

(STATE THE NUMBERS OR OTHER IDENTIFICATION OF ACCEPTED ALTERNATES, BUT ONLY IF A
GUARANTEED MAXIMUM PRICE IS INSERTED IN SUBPARAGRAPH 5.2.1. IF DECISIONS ON
OTHER ALTERNATES ARE TO BE MADE BY THE OWNER SUBSEQUENT TO THE EXECUTION OF THIS
AGREEMENT, ATTACH A SCHEDULE OF SUCH OTHER ALTERNATES SHOWING THE AMOUNT FOR
EACH AND THE DATE UNTIL WHICH THAT AMOUNT IS VALID.)

5.2.2.4   The Owner shall have the right at any time to notify the Contractor
if, in the Owners opinion, any Supplemental Drawings and Specifications are
grounds for a change in the Contract Sum, Guaranteed Maximum Price, Construction
Schedule and/or Milestone Dates, as applicable. Any disagreement between the
Owner and the Contractor relating to such claim by the Owner that is not
resolved by such parties shall be subject to the to the dispute resolution
procedures set forth in Article 4 of the General Conditions of the Contract.

5.2.3     The amounts agreed to for allowances are as set forth in SCHEDULE E
attached hereto and made a part hereof.

(STATE UNIT PRICES ONLY IF A GUARANTEED MAXIMUM PRICE IS INSERTED IN
SUBPARAGRAPH 5.2.1.)

5.2.4     Schedule J lists (a) certain items (the "Alternates") which may, at
the Owners election, be added to or removed from the Work and (b) the agreed
amount of the increase or decrease in the Guaranteed Maximum Price for each
Alternate selected by the Owner.

                                    ARTICLE 6
                               CHANGES IN THE WORK

6.1       CONTRACTS WITH A GUARANTEED MAXIMUM PRICE

6.1.1     Adjustments to the Guaranteed Maximum Price on account of changes in
the Work may be determined by any of the methods listed in Subparagraph 7.3.3 of
the General Conditions.

6.1.2     In calculating adjustments to subcontracts (except those awarded with
the Owner's prior consent on the basis of cost plus a fee), the terms "cost" and
"fee" as used in Clause 7.3.3.3 of the General Conditions and the terms "costs"
and "a reasonable allowance for overhead and profit" as used in Subparagraph
7.3.6 of the General Conditions shall have the meanings assigned to them in the
General Conditions and shall not be modified by Articles 5, 7 and 8 of this
Agreement. Adjustments to subcontracts awarded with the Owner's prior consent on
the basis of cost plus a fee shall be calculated in accordance with the terms of
those subcontracts.

6.1.3     In calculating adjustments to this Contract, the terms "cost" and
"costs" as used in the above-referenced provisions of the General Conditions
shall mean the Cost of the Work as defined in Article 7 of this Agreement and
the terms "fee" and "a reasonable allowance for overhead and profit" shall mean
the Contractor's Fee as defined in Paragraph 5.1 of this Agreement.

6.2       CONTRACTS WITHOUT A GUARANTEED MAXIMUM PRICE

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6.2.1

6.3       ALL CONTRACTS

6.3.1

                                    ARTICLE 7
                             COSTS TO BE REIMBURSED

7.1       The term Cost of the Work shall mean costs necessarily incurred by the
Contractor in the proper performance of the Work. Such costs shall be at rates
not higher than the standard paid at the place of the Project except with prior
consent of the Owner. The Cost of the Work shall include only the items set
forth in this Article 7.

7.1.1     LABOR COSTS

7.1.1.1   Wages of construction workers directly employed by the Contractor to
perform the construction of the Work at the site or, with the Owner's agreement,
at off-site workshops, at hourly rates not exceeding the rates listed in the
SCHEDULE H attached hereto. SCHEDULE H includes all labor burden, and related
expenses (including, without limitation, those items listed in subparagraphs
7.1.1.3 and 7.1.1.4). The provisions of this Paragraph 7.1.1.1 shall be subject
to the provisions of Paragraph 10.4 hereof.

7.1.1.2   Wages or salaries of the Contractor's or its affiliates' supervisory
and administrative personnel (a) when stationed at the site with the Owner's
agreement and (b) when stationed at the Contractor's or its affiliates' offices,
but only for such supervisory or administrative personnel as are specified in
SCHEDULE H hereto. The aggregate reimbursable labor costs for the Contractor's
or its affiliates' personnel shall be the hourly rates listed on SCHEDULE H
(which includes all labor burden).

(IF IT IS INTENDED THAT THE WAGES OR SALARIES OF CERTAIN PERSONNEL STATIONED AT
THE CONTRACTOR'S PRINCIPAL OR OTHER OFFICES SHALL BE INCLUDED IN THE COST OF THE
WORK, IDENTIFY IN ARTICLE 14 THE PERSONNEL TO BE INCLUDED AND WHETHER FOR ALL OR
ONLY PART OF THEIR TIME)

7.1.1.3   Wages and salaries of the Contractor's supervisory or administrative
personnel engaged, at factories, workshops or on the road, in expediting the
production or transportation of materials or equipment required for the Work,
but only for that portion of their time required for the Work.

7.1.1.4   Costs paid or incurred by the Contractor for taxes, insurance,
contributions, assessments and benefits required by law or collective bargaining
agreements and, for personnel not covered by such agreements, customary benefits
such as sick leave, medical and health benefits, holidays, vacations and
pensions, provided such costs are based on wages and salaries included in the
Cost of the Work under Clauses 7.1.1.1 through 7.1.1.3.

7.1.2     SUBCONTRACT COSTS

Payments made by the Contractor to Subcontractors in accordance with the
requirements of the subcontracts.

7.1.3     COSTS OF MATERIALS AND EQUIPMENT INCORPORATED IN THE COMPLETED
CONSTRUCTION

7.1.3.1   Costs, including transportation, of materials and equipment
incorporated or to be incorporated in the completed construction.

7.1.3.2   Costs of materials described in the preceding Clause 7.1.3.1 in excess
of those actually installed but required to provide reasonable allowance for
waste and for spoilage. Unused excess materials, if any, shall be handed over to
the Owner at the completion of the Work or, at the Owner's option, shall be sold
and any unsold

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materials disposed by the Contractor; amounts realized, if any, from such sales
shall be credited to the Owner as a deduction from the Cost of the Work.

7.1.4     COSTS OF OTHER MATERIALS AND EQUIPMENT, TEMPORARY FACILITIES AND
RELATED ITEMS

7.1.4.1   Costs, including transportation, installation, maintenance,
dismantling and removal of materials, supplies, temporary facilities, machinery,
equipment, and hand tools not customarily owned by the construction workers,
which are provided by the Contractor at the site and fully consumed in the
performance of the Work; and cost less salvage value on such items if not fully
consumed, whether sold to others or retained by the Contractor. Cost for items
previously used by the Contractor shall mean fair market value.

7.1.4.2   Rental charges for temporary facilities, machinery, equipment, and
hand tools not customarily owned by the construction workers, which are provided
by the Contractor at the site, whether rented from the Contractor or others, and
costs of transportation, installation, minor repairs and replacements,
dismantling and removal thereof. Rates and quantities of equipment rented shall
be subject to the Owner's prior approval. Rental charges shall be consistent
with those generally prevailing in the location of the Project. In no event
shall the Contractor be entitled to reimbursement for any cumulative total of
rental charges in connection with any single piece of machinery or equipment in
excess of eighty percent (80%) of its fair market value as of the date that such
machinery or equipment is first put into service in connection with the Work.
The Contractor shall pay any excess rental charges.

7.1.4.2.1      Equipment purchased and charged to the Project as a reimbursable
cost shall become the property of the Owner or, at the Owner's  election,  shall
be sold by the Contractor  and the amounts  realized by such sales shall be paid
to the Owner or credited to the Owner as a deduction from the Cost of the Work.

7.1.4.2.2      Any lease/purchase rental arrangements must be disclosed to the
Owner. If the Contractor purchases equipment under a lease/purchase  arrangement
whereby  rental  payments were charged to the Owner as  reimbursable  costs,  an
appropriate  credit will be given to the Owner for the fair market  value of the
equipment at the time it was last used on the Project.

7.1.4.2.3      For equipment owned by the Contractor or an Affiliate, the
Contractor  shall maintain daily  equipment  usage time reports noting the hours
and activity for which the equipment was used,  standby  time,  idle time,  etc.
Such  equipment  usage reports will be used by  Contractor to determine  whether
hourly,  daily,  weekly or monthly  rates  shall  apply;  and the rates used for
billing  purposes  will be  those  most  economical  to the  Owner  based on the
circumstances of actual usage.

7.1.4.3   Costs of removal of debris from the site.

7.1.4.4   Costs of telegrams and long-distance telephone calls, postage and
parcel delivery charges, telephone service at the site and reasonable petty cash
expenses of the site office.

7.1.4.5   That portion of the reasonable travel and subsistence expenses of the
Contractor's personnel incurred while traveling in discharge of duties connected
with the Work.

7.1.5     MISCELLANEOUS COSTS

7.1.5.1   That portion directly attributable to this Contract of premiums for
insurance and bonds, required by the Contract Documents. If the Contractor is
self-insured to any extent or purchases insurance coverage through any
subsidiary, parent company, or other affiliate, any such insurance arrangement
must be disclosed to the Owner and approved by the Owner in writing in advance
before any such insurance costs will be considered reimbursable under the terms
of this Agreement. The Contractor's method for determining actual cost of such
insurance coverage will be detailed to the Owner in writing in advance and will
be subject to the Owner verification of the representations made by the
Contractor. Reimbursable insurance costs under any such self-insurance or
related party insurance arrangements will be subject to agreed upon maximums and
not otherwise considered reimbursable unless advance written approval has been
obtained. Actual reimbursable costs for such insurance coverage will be subject
to audit

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verification of actual out-of-pocket insurance premium costs. The costs of such
insurance premiums which are considered reimbursable will be limited to a
maximum of rates not higher than normally paid to third party insurance
companies for similar coverage. Proper cost reduction consideration will be
given to cost reductions available due to favorable experience modifiers, volume
discounts, trade discounts, dividends, and the like.

7.1.5.2   Sales, use or similar taxes imposed by a governmental authority which
are related to the Work and for which the Contractor is liable.

7.1.5.3   Fees and assessments for the building permit and for other permits,
licenses and inspections for which the Contractor is required by the Contract
Documents to pay.

7.1.5.4   Fees of testing laboratories for tests required by the Contract
Documents, except those related to defective or nonconforming Work for which
reimbursement is excluded by Subparagraph 13.5.3 of the General Conditions or
other provisions of the Contract Documents and which do not fall within the
scope of Subparagraphs 7.2.2 through 7.2.4 below.

7.1.5.5   Royalties and license fees paid for the use of a particular design,
process or product required by the Contract Documents; the cost of defending
suits or claims for infringement of patent rights arising from such requirement
by the Contract Documents; payments made in accordance with legal judgments
against the Contractor resulting from such suits or claims and payments of
settlements made with the Owner's consent; provided, however, that such costs of
legal defenses, judgment and settlements shall not be included in the
calculation of the Contractor's Fee or of a Guaranteed Maximum Price, if any,
and provided that such royalties, fees and costs are not excluded by the last
sentence of Subparagraph 3.17.1 of the General Conditions or other provisions of
the Contract Documents.

7.1.5.6   Deposits lost for causes other than the Contractor's fault or
negligence.

7.1.6     OTHER COSTS

7.1.6.1   Other costs incurred in the performance of the Work if and to the
extent approved in advance in writing by the Owner.

7.2       EMERGENCIES: REPAIRS TO DAMAGED, DEFECTIVE OR NONCONFORMING WORK

The Cost of the Work shall also include costs described in Paragraph 7.1 which
are incurred by the Contractor:

7.2.1     In taking action to prevent threatened damage, injury or loss in case
of an emergency affecting the safety of persons and property, as provided in
Paragraph 10.3 of the General Conditions, unless such emergency, results solely
from the fault or negligence of the Contractor or any person for whom the
Contractor is responsible, including Subcontractors.

7.2.2     In repairing or correcting Work damaged or improperly executed by
construction workers in the employ of the Contractor, provided such damage or
improper execution did not result from the fault or negligence of the Contractor
or the Contractor's foremen, engineers or superintendents, or other supervisory,
administrative or managerial personnel of the Contractor.

7.2.3     In repairing damaged Work other than that described in Subparagraph
7.2.2, provided such damage did not result from the fault or negligence of the
Contractor or the Contractor's personnel, and only to the extent that the cost
of such repairs is not recoverable by the Contractor from others and the
Contractor is not compensated therefor by insurance or otherwise.

7.2.4     In correcting defective or nonconforming Work performed or supplied by
a Subcontractor or material supplier and not corrected by them, provided such
defective or nonconforming Work did not result from the fault or neglect of the
Contractor or the Contractor's personnel adequately to supervise and direct the
Work of the Subcontractor or material supplier, and only to the extent that the
cost of correcting the defective or nonconforming

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Work is not recoverable by the Contractor from the Subcontractor or material
supplier.

7.3       GENERAL CONDITIONS

7.3.1     The term "General Conditions" shall mean, collectively, those properly
reimbursable Cost of the Work items that are specified in SCHEDULE F attached
hereto. The General Conditions costs shall be the lump sum amount of five
hundred twenty four thousand one hundred and fifteen dollars ($524,115).
Notwithstanding anything to the contrary in any of the Contract Documents, (a)
the costs of the General Conditions shall be paid to the Contractor in monthly
installments which, for any month, shall be calculated by dividing the remaining
General Conditions amount by the number of months from that month to the
scheduled date for Substantial Completion of all the Work, and (b) there shall
be no increase in the General Conditions costs for changes in the Work.

7.4       GMP BREAKDOWN

7.4.1     The GMP Breakdown includes a "Contingency" line item in the amount
noted thereon. The Contingency shall be an amount available to reimburse the
Contractor for unanticipated costs for any of the Cost of the Work items
provided for in Article 7. Following the execution of this Agreement, the
Contractor, with the participation of the Owner and the Architect, shall select
Subcontractors and suppliers who shall provide labor, equipment and materials
related to completion of the Work. As this "buyout" process is completed, the
GMP Breakdown shall be revised and the actual costs associated with the line
items in the GMP Breakdown attached hereto shall be incorporated into such GMP
Breakdown. Any net savings between the estimated costs as reflected in the
original GMP Breakdown and the actual Subcontractor and supplier award amounts
resulting from the buyout process shall be allocated to the "Contingency" line
item. The Contractor shall notify the Owner in writing prior to incurring costs
that the Contractor proposes be charged to the Contingency, together with an
explanation of the reason such cost is to be incurred. Any application of funds
from the Contingency shall be subject to the Owner's receipt of such prior
written notice and a reasonable opportunity to comment thereon.

7.4.2     Notwithstanding anything to the contrary, the Contractor shall not
apply any portion of the Contingency for costs incurred in repairing or
correcting defective or nonconforming Work subsequent to final payment.

7.5       COSTS

7.5.1     Costs as defined herein shall be actual costs paid by the Contractor,
less all discounts, rebates and salvages which shall be taken by the Contractor,
subject to Article 9 of the Agreement.

7.5.2     Notwithstanding the breakdown or categorization of any costs to be
reimbursed in this Article 7 or elsewhere in the Contract Documents, there shall
be no duplication of payment in the event any particular items for which payment
is requested can be characterized as falling into more than one of the types of
compensable or reimbursable categories.

                                    ARTICLE 8
                           COSTS NOT TO BE REIMBURSED

8.1       The Cost of the Work shall not include:

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8.1.1     Salaries and other compensation of the Contractor's personnel
stationed at the Contractor's principal office or offices other than the site
office, except as specifically provided in Clauses 7.1.1.2 and 7.1.1.3 or as may
be provided in Article 14.

8.1.2     Expenses of the Contractor's principal office and offices other than
the site office, except as otherwise expressly included in the Cost of the Work
pursuant to Subparagraph 7.1.1.2.

8.1.3     Overhead and general expenses, except as may be expressly included in
Article 7.

8.1.4     The Contractor's capital expenses, including interest on the
Contractor's capital employed for the Work.

8.1.5     Rental costs of machinery and equipment, except as specifically
provided in Clause 7.1.4.2.

8.1.6     Notwithstanding anything to the contrary contained in Subparagraphs
7.2.2 through 7.2.4 and Paragraph 13.5 of this Agreement, costs due to the fault
or negligence of the Contractor, Subcontractors, anyone directly or indirectly
employed by any of them, or for whose acts any of them may be liable, including
but not limited to costs for the correction of damaged, defective or
nonconforming Work, disposal and replacement of materials and equipment
incorrectly ordered or supplied, and making good damage to property not forming
part of the Work.

8.1.7     Any cost not specifically and expressly described in Article 7.

8.1.8     Costs which would cause the Guaranteed Maximum Price, if any, to be
exceeded.

8.1.9     Labor, material, and equipment costs or any other costs incurred which
the Contractor and the Owner agree should be backcharged to subcontractors or
material suppliers.

8.1.10    Losses resulting from lost, damaged or stolen tools and equipment.

                                    ARTICLE 9
                         DISCOUNTS, REBATES AND REFUNDS

9.1       Cash discounts obtained on payments made by the Contractor shall
accrue to the Owner if (1) before making the payment, the Contractor included
them in an Application for Payment and received payment therefor from the Owner,
or (2) the Owner has deposited funds with the Contractor with which to make
payments; otherwise, cash discounts shall accrue to the Contractor. Trade
discounts, rebates, refunds and amounts received from sales of surplus materials
and equipment shall accrue to the Owner, and the Contractor shall make
provisions so that they can be secured. The Contractor shall not obtain for its
own benefit any discounts, rebates or refunds in connection with the Work prior
to providing the Owner with seven (7) days prior written notice of the potential
discount, rebate or refund and an opportunity to furnish funds necessary to
obtain such discount, rebate or refund on behalf of the Owner in accordance with
the requirements of this Paragraph 9.1.

9.2       Amounts which accrue to the Owner in accordance with the provisions of
Paragraph 9.1 shall be credited to the Owner as a deduction from the Cost of the
Work, and shall reduce the amount of the Guaranteed Maximum Price by the same
amount.

9.3       Reimbursable costs will be credited with insurance policy discounts,
rebates, refunds or dividends, and a proportion of any volume rebates earned
with purchase of material charged to this job.

                                   ARTICLE 10
                        SUBCONTRACTS AND OTHER AGREEMENTS

10.1      Those portions of the Work that the Contractor does not customarily
perform with the Contractor's own personnel shall be performed under
subcontracts or by other appropriate agreements with the Contractor. The
Contractor shall obtain bids from Subcontractors and from suppliers of materials
or equipment fabricated especially

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for the Work and shall deliver such bids to the Architect. The Owner will then
determine, with the advice of the Contractor and subject to the reasonable
objection of the Architect, which bids will be accepted. The Owner may designate
specific persons or entities from whom the Contractor shall obtain bids;
however, if a Guaranteed Maximum Price has been established, the Owner may not
prohibit the Contractor from obtaining bids from others. The Contractor shall
not be required to contract with anyone to whom the Contractor has reasonable
objection.

10.2      If a Guaranteed Maximum Price has been established and a specific
bidder among those whose bids are delivered by the Contractor to the Architect
(1) is recommended to the Owner by the Contractor; (2) is qualified to perform
that portion of the Work; and (3) has submitted a bid which conforms to the
requirements of the Contract Documents without reservations or exceptions, but
the Owner requires that another bid be accepted; then the Contractor may require
that a Change Order be issued to adjust the Guaranteed Maximum Price by the
difference between the bid of the person or entity recommended to the Owner by
the Contractor and the amount of the subcontract or other agreement actually
signed with the person or entity designated by the Owner.

10.3      Subcontracts or other agreements shall conform to the payment
provisions of Paragraphs 12.7 and 12.8, and shall not be awarded on the basis of
cost plus a fee without the prior consent of the Owner.

10.4      Except as otherwise agreed in writing by both parties hereto,
Contractor must competitively bid any trade Work that Contractor wishes to
perform with Contractor's own forces, or through an Affiliate, and shall obtain
no less than two (2) additional responsive bids from responsible Subcontractors
acceptable to Owner. Contractor's bid shall be submitted to Owner at least one
day in advance of the Contractor's receipt of bids from the unaffiliated
Subcontractors. Contractor, or an Affiliate, shall be permitted to perform such
trade Work only if (i) Owner consents thereto in writing after full disclosure
in writing by Contractor to Owner of the affiliation or relationship of the
Affiliate to Contractor and (ii) Owner approves in writing any subcontract,
contract, purchase order, agreement or other arrangement between Contractor and
such Affiliate in form and substance. Any trade Work performed by Contractor's
own forces or by an Affiliate if required by Owner, shall be covered in a
separate agreement between Owner and Contractor or the Affiliate. The term
"Affiliate" is hereby deemed to mean any party or entity related to or
affiliated with Contractor or in which Contractor has direct or indirect
ownership or control, including, without limitation: (i) any entity owned in
whole or in part by Contractor; (ii) any party or entity with an ownership
interest in Contractor; and (iii) any entity in which any officer, director,
employee, partner or shareholder (or member of the family of any of the
foregoing persons) of Contractor or any entity owned by Contractor has a direct
or indirect interest. The Contractor shall not enter into any subcontract,
contract, purchase order, or other such agreement in connection with the Work
with any Affiliate unless such arrangement has been approved in writing by
Owner, after full disclosure in writing by Contractor to Owner of such
affiliation or relationship and all details relating to the proposed agreement.
The terms of any such agreement must conform to the requirements of the Contract
Documents.

                                   ARTICLE 11
                               ACCOUNTING RECORDS

11.1      The Contractor shall keep full and detailed accounts and exercise such
controls as may be necessary for proper financial management under this
Contract; the accounting and control systems shall be satisfactory to the Owner.
The Owner and the Owner's accountants shall be afforded access to the
Contractor's records, books, correspondence, instructions, drawings, receipts,
subcontracts, purchase orders, vouchers, memoranda and other data relating to
this Contract, and the Contractor shall preserve these for a period of three
years after final payment, or for such longer period as may be required by law.

11.2      Records to be available for audit shall include but not be limited to
accounting records, written policies and procedures; contract and subcontract
files (including proposals of successful and unsuccessful bidders, bid recaps,
etc.); original estimates; estimating worksheets; correspondence invoices;
change order files (including documentation covering negotiated settlements);
backcharge logs and supporting documentation; general ledger entries detailing
cash and trade discounts earned, insurance rebates and dividends, and any other
supporting evidence deemed necessary to substantiate charges. These records
shall be open to inspection and subject to audit and/or reproduction to the
extent necessary to adequately permit evaluation and verification of the Cost of
the Work,

<Page>

and any invoices, change orders, payments or claims submitted by the contractor
or vendor to any of his payees pursuant to the execution of the Agreement.

11.3      Such audits may require inspection and copying from time to time and
at reasonable times and places of any and all information, materials and data of
every kind and character, including without limitation, records, books, papers,
documents, subscriptions, recordings, agreements, purchase orders, leases,
contracts, commitments, arrangements, notes, daily diaries, superintendent's
reports, drawings, receipts, vouchers and memoranda, and any and all other
agreements, sources of information and matters that have any bearing on or
pertain to any records subject to audit. This material shall also include, but
not be limited to, those records necessary to evaluate and verify direct and
indirect costs (including overhead allocations).

11.4      Access shall be afforded to all of the Contractor's records
specifically related to the Project, and the auditor shall be allowed to
interview any of the Contractor's employees, for a period of three years after
final payment or longer if required by law.

11.5      Access shall be provided to the Contractor's facilities and all
necessary records for the purpose of an audit, and adequate and appropriate work
space will be provided in order to conduct audits in compliance with this
article.

11.6      If an audit or examination of the Contractor's records discloses
overcharges (of any nature) by the Contractor, then, at the Owner's option,
either the Contractor shall immediately reimburse the Owner for such overcharge
or the Owner may deduct the amount of such overcharges from amounts otherwise
owed by the Owner to the Contractor. In the event the amount of such overcharge
is intentional or willful, the Contractor shall also reimburse the Owner for the
administrative expenses incurred by the Owner in determining the overcharge.

                                   ARTICLE 12
                                PROGRESS PAYMENTS

12.1      Based upon Applications for Payment, including all supporting
documentation, submitted to the Architect by the Contractor and Certificates for
Payment issued by the Architect, the Owner shall make progress payments on
account of the Contract Sum to the Contractor as provided below and elsewhere in
the Contract Documents. The Contractor's Applications for Payment shall be
submitted on AIA Document G702 together with AIA Document G703.

12.2      The period covered by each Application for Payment shall be one
calendar month ending on the last day of the month, or as follows:

12.3      Provided an Application for Payment together with all required
supporting documentation properly prepared and submitted is received by the
Architect not later than the first day of a month, the Owner shall make payment
to the Contractor not later than the last day of such month. If an Application
for Payment is received by the Architect after the application date fixed above,
payment shall be made by the Owner not later than forty-five (45) days after the
Architect receives the Application for Payment.

12.4      With each Application for Payment the Contractor shall submit
payrolls, petty cash accounts, receipted invoices or invoices with check
vouchers attached, and any other evidence required by the Owner or Architect to
demonstrate that cash disbursements already made by the Contractor on account of
the Cost of the Work equal or exceed (1) progress payments already received by
the Contractor; less (2) that portion of those payments attributable to the
Contractor's Fee; plus (3) payrolls for the period covered by the present
Application for Payment; plus (4) retainage provided in Subparagraph 12.5.4, if
any, applicable to prior progress payments. In addition to other required items,
each Application for Payment shall be accompanied by the following, all in form
and substance satisfactory to the Owner:

          (1)  A duly executed and acknowledged Contractor's Sworn Statement, in
the form attached hereto as EXHIBIT A, showing all suppliers who have provided
supplies and/or materials to the Project and Subcontractors with whom the
Contractor has entered into subcontracts, the amounts of such subcontracts, the
amount requested for

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any Subcontractor in the Application for Payment and the amount to be paid to
the Contractor from such progress payment;

          (2)  A duly executed Waiver of Mechanics' and Materialmen's Liens from
the Contractor in the form attached hereto as EXHIBIT B;

          (3)  Duly executed Waivers of Mechanics' and Materialmen's Liens, in
the form attached hereto as EXHIBIT C, from all Subcontractors and suppliers;

          (4)  Applications for payment from each Subcontractor on AIA Document
G702 together with AIA Document G703;

          (5)  A progress report updating the actual status of construction
against the most recent Construction Schedule approved by the Owner;

          (6)  Prior to or with the first Application for Payment which requests
a cash disbursement for each Subcontractor, a detailed trade payable schedule
setting forth a schedule of values and anticipated payment schedule for such
Subcontractor's Work; and

          (7)  Such other information, documentation and materials as the Owner
or the Architect may require.

12.5      CONTRACTS WITH A GUARANTEED MAXIMUM PRICE

12.5.1    Each Application for Payment shall be based upon the most recent
schedule of values submitted by the Contractor and approved by the Owner in
accordance with the Contract Documents. The schedule of values shall allocate
the entire Guaranteed Maximum Price among the various portions of the Work,
except that the Contractor's Fee and the General Conditions shall be shown as
separate line items. The schedule of values shall be prepared in such form and
supported by such data to substantiate its accuracy as the Architect may
require. This schedule, unless-objected to by the Architect, shall be used as a
basis for reviewing the Contractor's Applications for Payment.

12.5.2    Applications for Payment shall show the percentage completion of each
portion of the Work as of the end of the period covered by the Application for
Payment. The percentage completion shall be the lesser of (1) the percentage of
that portion of the Work which has actually been completed or (2) the percentage
obtained by dividing (a) the expense which has actually been incurred by the
Contractor on account of that portion of the Work for which the Contractor has
made or intends to make actual payment prior to the next Application for Payment
by (b) the share of the Guaranteed Maximum Price allocated to that portion of
the Work in the schedule of values.

12.5.3    Subject to other provisions of the Contract Documents, the amount of
each progress payment shall be computed as follows:

12.5.3.1       Take that portion of the Guaranteed Maximum Price properly
allocable to completed Work as determined by multiplying the percentage
completion of each portion of the Work by the share of the Guaranteed Maximum
Price allocated to that portion of the Work in the schedule of values. Pending
final determination of cost to the Owner of changes in the Work, amounts not in
dispute may be included as provided in Subparagraph 7.3.7 of the General
Conditions, even though the Guaranteed Maximum Price has not yet been adjusted
by Change Order. Except with respect to General Conditions items, amounts
payable in accordance with this Subparagraph 12.5.3.1 shall be reduced by
retainage in the amount of ten percent (10.0%). Retainage shall not be withheld
from amounts payable to the Contractor for General Conditions items.

12.5.3.2       Add that portion of the Guaranteed Maximum Price properly
allocable to materials and equipment delivered and suitably stored at the site
for subsequent incorporation in the Work or, if approved in advance by the Owner
and permitted by the Owner's construction lender, suitably stored off the site
at a location agreed upon in writing. Amounts payable in accordance with this
Subparagraph 12.5.3.2 shall be reduced by retainage of ten percent (10.0%).

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12.5.3.3       Add the Contractor's Fee, less retainage of ten percent (10.0%).
The Contractor's Fee shall be computed upon the Cost of the Work described in
the two preceding Clauses at the rate stated in Paragraph 5.1 or, if the
Contractor's Fee is stated as a fixed sum in that Paragraph, shall be an amount
which bears the same ratio to that fixed-sum Fee as the Cost of the Work in the
two preceding Clauses bears to a reasonable estimate of the probable Cost of the
Work upon its completion.

12.5.3.4       Subtract the aggregate of previous payments made by the Owner.

12.5.3.5       Subtract the shortfall, if any, indicated by the Contractor in
the documentation required by Paragraph 12.4 to substantiate prior Applications
for Payment, or resulting from errors subsequently discovered by the Owner's
accountants in such documentation.

12.5.3.6       Subtract amounts, if any, for which the Architect has withheld or
nullified a Certificate for Payment as provided in Paragraph 9.5 of the General
Conditions.

12.5.4    Additional retainage, if any, shall be as follows:
(IF IT IS INTENDED TO RETAIN ADDITIONAL AMOUNTS FROM PROGRESS PAYMENTS TO THE
CONTRACTOR BEYOND (1) THE RETAINAGE FROM THE CONTRACTOR'S FEE PROVIDED IN CLAUSE
12.5.3.3., (2) THE RETAINAGE FROM SUBCONTRACTORS PROVIDED IN PARAGRAPH 12.7
BELOW, AND (3) THE RETAINAGE, IF ANY, PROVIDED BY OTHER PROVISIONS OF THE
CONTRACT, INSERT PROVISION FOR SUCH ADDITIONAL RETAINAGE HERE. SUCH PROVISION,
IF MADE, SHOULD ALSO DESCRIBE ANY ARRANGEMENT FOR LIMITING OR REDUCING THE
AMOUNT RETAINED AFTER THE WORK REACHES A CERTAIN STATE OF COMPLETION.)

12.6      CONTRACTS WITHOUT A GUARANTEED MAXIMUM PRICE

12.6.1

12.6.2

12.6.2.1

12.6.2.2

12.6.2.3

12.6.2.4

12.6.2.5

12.6.3

12.7      Except with the Owner's prior approval, payments to Subcontractors
included in the Contractor's Applications for Payment shall not exceed an amount
for each Subcontractor calculated as follows:

12.7.1    Take that portion of the Subcontract Sum properly allocable to
completed Work as determined by multiplying the percentage completion of each
portion of the Subcontractor's Work by the share of the total Subcontract Sum
allocated to that portion in the Subcontractor's schedule of values, less
retainage of ten percent (10.0%). Pending final determination of amounts to be
paid to the Subcontractor for changes in the Work, amounts

<Page>

not in dispute may be included as provided in Subparagraph 7.3.7 of the General
Conditions even though the Subcontract Sum has not yet been adjusted by Change
Order. Notwithstanding the foregoing, at the Owner's discretion and subject to
the approval of the Owner's construction lender in each instance, after such
time as the total Cost of the Work completed, as reflected in Applications for
Payment certified by the Architect, equals fifty percent (50%) of the Guaranteed
Maximum Price: (1) no additional retainage shall be withheld from amounts
payable to a Subcontractor after such time as the Cost of the Work allocable to
Subcontractor's Work completed, as reflected in Applications for Payment
certified by the Architect, equals fifty percent 50% of the Subcontract Sum; and
(2) the entire retainage allocable to such Subcontractor's Work shall be
released when such Subcontractor fully performs such Subcontractor's Work.
Notwithstanding anything to the contrary in this subparagraph 12.7.1, the
following provisions shall apply to the Subcontractors listed on SCHEDULE K only
(collectively, the "Designated Subcontractors") regardless of whether the total
Cost of the Work for the Project completed, as reflected in Applications for
Payment certified by the Architect, equals fifty percent (50%) of the Guaranteed
Maximum Price for the Project: (1) no additional retainage shall be withheld
from amounts payable to a Designated Subcontractor after such time as the Cost
of the Work allocable to such Designated Subcontractor's Work completed, as
reflected in Applications for Payment certified by the Architect, equals fifty
percent (50%) of the Subcontract Sum; and (2) the entire retainage allocable to
such Designated Subcontractor's Work shall be released when such Designated
Subcontractor fully performs such Designated Subcontractor's Work.

12.7.2    Add that portion of the Subcontract Sum properly allocable to
materials and equipment delivered and suitably stored at the site for subsequent
incorporation in the Work or, if approved in advance by the Owner, suitably
stored off the site at a location agreed upon in writing, less retainage of ten
percent (10%).

12.7.3    Subtract the aggregate of previous payments made by the Contractor to
the Subcontractor.

12.7.4    Subtract amounts, if any, for which the Architect has withheld or
nullified a Certificate for Payment by the Owner to the Contractor for reasons
which are the fault of the Subcontractor.

12.7.5

(IF IT IS INTENDED, PRIOR TO SUBSTANTIAL COMPLETION OF THE ENTIRE WORK OF THE
CONTRACTOR, TO REDUCE OR LIMIT THE RETAINAGE FROM SUBCONTRACTORS RESULTING FROM
THE PERCENTAGES INSERTED IN SUBPARAGRAPHS 12.7.1 AND 12.7.2 ABOVE, AND THIS IS
NOT EXPLAINED ELSEWHERE IN THE CONTRACT DOCUMENTS, INSERT HERE PROVISIONS FOR
SUCH REDUCTION OR LIMITATION.)

12.8      Except with the Owner's prior approval, the Contractor shall not make
advance payments to suppliers for materials or equipment which have not been
delivered and stored at the site.

12.9      In taking action on the Contractor's Applications for Payment, the
Architect shall be entitled to rely on the accuracy and completeness of the
information furnished by the Contractor and shall not be deemed to represent
that the-Architect has made a detailed examination, audit or arithmetic
verification of the documentation submitted in accordance with Paragraph 12.4 or
other supporting data; that the Architect has made exhaustive or continuous
on-site inspections or that the Architect has made examinations to ascertain how
or for what purposes the Contractor has used amounts previously paid on account
of the Contract. Such examinations, audits and verifications, if required by the
Owner, will be performed by the Owner's accountants acting in the sole interest
of the Owner.

12.10     Upon achievement of Substantial Completion of the Work, the Owner
shall release all retainage to the Contractor except an amount equal to the sum
of (i) two percent (2%) of the Contractor's Fee plus (ii) two hundred percent
(200%) of the value of incomplete or defective Work as identified in the
Punchlist.

<Page>

                                   ARTICLE 13
                                  FINAL PAYMENT

13.1      Final payment shall be made by the Owner to the Contractor when (1)
the Contract has been fully performed by the Contractor except for the
Contractor's responsibility to correct defective or nonconforming Work, as
provided in Subparagraph 12.2.2 of the General Conditions, and to satisfy other
requirements, if any, which necessarily survive final payment; (2) a final
Application for Payment and a final accounting for the Cost of the Work and all
required supporting documentation have been submitted by the Contractor and
reviewed by the Owner's accountants; and (3) a final Certificate for Payment has
then been issued by the Architect; such final payment shall be made by the Owner
not more than 30 days after the issuance of the Architect's final Certificate
for Payment, or as follows:

13.2      The amount of the final payment shall be calculated as follows:

13.2.1    Take the sum of the Cost of the Work substantiated by the Contractor's
final accounting and the Contractor's Fee; but not more than the Guaranteed
Maximum Price, if any.

13.2.2    Subtract amounts, if any, for which the Architect withholds, in whole
or in part, a final Certificate for Payment as provided in Subparagraph 9.5.1 of
the General Conditions or other provisions of the Contract Documents.

13.2.3    Subtract the aggregate of previous payments made by the Owner.

If the aggregate of previous payments made by the Owner exceeds the amount due
the Contractor, the Contractor shall reimburse the difference to the Owner.

13.3      The Owner's accountants will review and report in writing on the
Contractor's final accounting within 30 days after delivery of the final
accounting to the Architect by the Contractor. Based upon such Cost of the Work
as the Owner's accountants report to be substantiated by the Contractor's final
accounting, and provided the other conditions of Paragraph 13.1 have been met,
the Architect will, within seven days after receipt of the written report of the
Owner's accountants, either issue to the Owner a final Certificate for Payment
with a copy to the Contractor, or notify the Contractor and Owner in writing of
the Architect's reasons for withholding a certificate as provided in
Subparagraph 9.5.1 of the General Conditions. The time periods stated in this
Paragraph 13.3 supersede those stated in Subparagraph 9.4.1 of the General
Conditions.

13.4      If the Owner's accountants report the Cost of the Work as
substantiated by the Contractor's final accounting to be less than claimed by
the Contractor, the Contractor shall be entitled to demand arbitration of the
disputed amount without a further decision of the Architect. Such demand for
arbitration shall be made by the Contractor within 30 days after the
Contractor's receipt of a copy of the Architect's final Certificate for Payment;
failure to demand arbitration within this 30-day period shall result in the
substantiated amount reported by the Owner's accountants becoming binding on the
Contractor. Pending a final resolution by arbitration, the Owner shall pay the
Contractor the amount certified in the Architect's final Certificate for
Payment.

13.5      If, subsequent to final payment and at the Owner's request, the
Contractor incurs costs described in Article 7 and not excluded by Article 8 to
correct defective or nonconforming Work, the Owner shall reimburse the
Contractor such costs and the Contractor's Fee applicable thereto on the same
basis as if such costs had been incurred prior to final payment, but not in
excess of the Guaranteed Maximum Price, if any. If the Contractor has
participated in savings as provided in Paragraph 5.2, the amount of such savings
shall be recalculated and appropriate credit given to the Owner in determining
the net amount to be paid by the Owner to the Contractor.

<Page>

                                   ARTICLE 14
                            MISCELLANEOUS PROVISIONS

14.1      Where reference is made in this Agreement to a provision of the
General Conditions or another Contract Document, the reference refers to that
provision as amended or supplemented by other provisions of the Contract
Documents.

14.2      Payments due and unpaid under the Contract shall bear interest from
the date payment is due at the rate
(INSERT RATE OF INTEREST AGREED UPON, IF ANY.)
equal to the "prime rate" as published in THE WALL STREET JOURNAL on the date
such payment was due or if THE WALL STREET JOURNAL was not published on such
date, the corresponding rate in the next issue of THE WALL STREET JOURNAL
published after the due date.
(USURY LAWS AND REQUIREMENTS UNDER THE FEDERAL TRUTH IN LENDING ACT, SIMILAR
STATE AND LOCAL CONSUMER CREDIT LAWS AND OTHER REGULATIONS AT THE OWNER'S AND
CONTRACTOR'S PRINCIPAL PLACES OF BUSINESS, THE LOCATION OF THE PROJECT AND
ELSEWHERE MAY AFFECT THE VALIDITY OF THIS PROVISION. LEGAL ADVICE SHOULD BE
OBTAINED WITH RESPECT TO DELETIONS OR MODIFICATIONS, AND ALSO REGARDING
REQUIREMENTS SUCH AS WRITTEN DISCLOSURES OR WAIVERS.)

14.3      Other provisions:

14.3.1    The Contractor represents and warrants the following to the Owner (in
addition to any other representations and warranties contained in the Contract
Documents) as a material inducement to the Owner to execute this Agreement,
which representations and warranties shall survive the execution and delivery of
this Agreement, any termination of this Agreement and the final completion of
the Work:

          (1)  the Contractor is financially solvent, able to pay all debts as
they mature and possessed of sufficient working capital to complete the Work and
perform all obligations hereunder;

          (2)  the Contractor is able to furnish the plant, tools, materials,
supplies, equipment and labor required to complete the Work and perform its
obligations hereunder and has sufficient experience and competence to do so;

          (3)  the Contractor is authorized to do business in the Commonwealth
of Massachusetts and is properly licensed by all necessary governmental and
public and quasi-public authorities having jurisdiction over the Contractor and
over the Work and the Project;

          (4)  the Contractor's execution of this Agreement and performance
thereof is within the Contractor's duly authorized powers;

          (5)  the Contractor's duly authorized representative has visited the
site of the Project and is familiar with the local conditions under which the
Work is to be performed and has correlated observations with the requirements of
the Contract Documents; and

          (6)  the Contractor possesses a high level of experience and expertise
in the business administration, construction, construction management and
superintendence of projects of the size, complexity and nature of this
particular Project and will perform the Work with the care, skill and diligence
of such a contractor.

14.3.2    The Contractor acknowledges that the Owner may finance the Work with
funds provided and/or administered by a construction lender (the "Lender"). The
Contractor agrees to use its best efforts to comply with the requirements of the
Lender which bear upon the performance of the Work, so long as these efforts do
not require the Contractor to cede or otherwise lose rights granted to it under
the Contract Documents to a greater extent than customary for similar
transactions. The Contractor shall also:

          (1)  make the site of the Work available at reasonable times for
inspection by the Lender or the Lender's representatives;

<Page>

          (2)  consent to and execute all documents reasonably requested by the
Owner in connection with the assignment of this Agreement and the Drawings and
Specifications to the Lender for collateral purposes (such assignment shall, at
the Owner's request, require the Contractor to continue performance of all
obligations hereunder on the same terms and conditions as are set forth herein
for and on account of the Lender following any default by the Owner hereunder
which would otherwise give the Contractor the right to terminate this Agreement
if the Lender shall (a) agree to pay the Contractor all amounts due and owing
the Construction from and after the date the Lender notifies the Contractor that
Lender has exercised its right to take assignment of this Agreement and (b)
agree in writing to perform all obligations of the Owner hereunder accruing from
and after the date of such notification from the Lender): and

          (3)  promptly furnish the Owner with information, documents and
materials that the Owner may reasonably request from time to time in order to
comply with the requirements of the Lender.

14.3.3    Reference is hereby made to the Forest City Commercial Group
Contractor Project Procedures Manual attached as EXHIBIT D hereto (the
"Procedures Manual"). The Contractor acknowledges that the Procedures Manual
forms a part of this Agreement and agrees to comply with the terms and
provisions thereof. In the event of any conflict between the terms and
provisions of the Procedures Manual and the other terms of this Agreement, such
terms and provisions shall be interpreted so as to require the most substantial
and comprehensive performance of the Work and better quality or greater quantity
of Work.

14.3.4    Reference is hereby made to the Construction Management Plan dated
9/24/01, a copy of which is attached as EXHIBIT E hereto (as amended from time
to time, the "Construction, Management Plan"). The Contractor acknowledges that
the Construction Management Plan forms a part of this Agreement and agrees to
comply with the terms and provisions thereof to the extent applicable to the
Work. In the event of any conflict between the terms and provisions of the
Construction Management Plan and the other terms of this Agreement, such terms
and provisions shall be interpreted so as to require the most substantial and
comprehensive performance of the Work and better quality and greater quantity of
Work.

14.3.5    The Owner, after giving the Contractor notice, may make payments on
account of labor, materials and/or equipment for the Work directly to the
Subcontractors or persons entitled to the same in lieu of paying the Contractor
therefor or make joint payment to any such person and the Contractor. Any
amounts so paid shall be credited against the Contract Sum. No such payment
shall create any relationship between the recipient thereof and the Owner, nor
any duty on the part of the Owner. The Contractor shall cooperate with the Owner
to facilitate any such direct payments and shall provide such evidence as the
Owner may request for purposes of determining any amount to be so paid. If the
Owner elects to make such payments as a result of a failure on the part of the
Contractor to perform in accordance with the Contract Documents, or as a result
of a request from the Contractor that the Owner make such payments, then the
Owner may offset or credit the amount of its administrative costs incurred in
making such payments against the Contract Sum or render an invoice to the
Contractor for such administrative costs, which invoice the Contractor shall pay
promptly. In the event that the Owner elects to exercise its rights under this
subparagraph 14.3.5, the Owner shall deliver written notice to the Contractor
setting forth in reasonable detail the Owner's reasons therefor.

14.3.6    The members of the Contractor's staff listed on SCHEDULE I (the "Key
Persons") shall have primary and direct responsibility for the Work in the
respective capacities noted on SCHEDULE I. Such Key Persons shall not be changed
without the written consent of the Owner, unless such person becomes unable to
perform his or her duties due to death, disability or termination of employment,
or unless the Owner requests removal. If a Key Person is no longer capable of
performing in the capacity described on SCHEDULE I, or is removed by the Owner,
the Contractor shall assign a replacement acceptable to the Owner.

                                   ARTICLE 15
                            TERMINATION OR SUSPENSION

15.1      The Contract may be terminated by the Contractor as provided in
Article 14 of the General Conditions; however, the amount to be paid to the
Contractor under Subparagraph 14.1.2 of the General Conditions shall not exceed
the amount the Contractor would be entitled to receive under Paragraph 15.3
below, except that unless such termination based on the reasons set forth in
14.1.1.1 or 14.1.1.2, the Contractor's Fee shall be calculated as if the

<Page>

Work had been fully completed by the Contractor, including a reasonable estimate
of the Cost of the Work for Work not actually completed.

15.2      If a Guaranteed Maximum Price is established in Article 5, the
Contract may be terminated by the Owner for cause as provided in Article 14 of
the General Conditions; however, the amount, if any, to be paid to the
Contractor under Subparagraph 14.2.4 of the General Conditions shall not cause
the Guaranteed Maximum Price to be exceeded, nor shall it exceed the amount the
Contractor would be entitled to receive under Paragraph 15.3 below.

15.3      If no Guaranteed Maximum Price is established in Article 5, the
Contract may be terminated by the Owner for cause as provided in Article 14 of
the General Conditions; however, the Owner shall then pay the Contractor an
amount calculated as follows:

15.3.1    Take the Cost of the Work incurred by the Contractor to the date of
termination.

15.3.2    Add the Contractor's Fee computed upon the Cost of the Work to the
date of termination at the rate stated in Paragraph 5.1 or, if the Contractor's
Fee is stated as a fixed sum in that Paragraph, an amount which bears the same
ratio to that fixed-sum Fee as the Cost of the Work at the time of termination
bears to a reasonable estimate of the probable Cost of the Work upon its
completion.

15.3.3    Subtract the aggregate of previous payments made by the Owner. The
Owner shall also pay the Contractor fair compensation, either by purchase or
rental at the election of the Owner, for any equipment owned by the Contractor
which the Owner elects to retain and which is not otherwise included in the Cost
of the Work under Subparagraph 15.3.1. To the extent that the Owner elects to
take legal assignment of subcontracts and purchase orders (including rental
agreements), the Contractor shall, as a condition of receiving the payments
referred to in this Article 15, execute and deliver all such papers and take all
such steps, including the legal assignment of such subcontracts and other
contractual rights of the Contractor, as the Owner may require for the purpose
of fully vesting in the Owner the rights and benefits of the Contractor under
such subcontracts or purchase orders.

15.4      The Work may be suspended by the Owner as provided in Article 14 of
the General Conditions; in such case, the Guaranteed Maximum Price, if any,
shall be increased as provided in Subparagraph 14.3.2 of the General Conditions
except that the term "cost of performance of the Contract" in that Subparagraph
shall be understood to mean the Cost of the Work and the term "profit" shall be
understood to mean the Contractor's Fee as described in Paragraphs 5.1 and 6.3
of this Agreement.

                                   ARTICLE 16
                        ENUMERATION OF CONTRACT DOCUMENTS

16.1      The Contract Documents, except for Modifications issued after
execution of this Agreement, are enumerated as follows:

16.1.1    The Agreement is this executed Standard Form of Agreement Between
Owner and Contractor, AIA Document A111, 1987 Edition.

16.1.2    The General Conditions are the General Conditions of the Contract for
Construction, AIA Document A201, 1987 Edition with modifications incorporated,
all as contained in the document prepared using the AIA Electronic Format
software and entitled "User Document: FC40LANDA201.DOC-- / /2001" (the "General
Conditions of the Contract"). All references in the Contract Documents to AIA
Document A201, the General Conditions or the General Conditions of the Contract
shall be deemed to refer to the General Conditions of the Contract.

16.1.3

<Table>
<Caption>
DOCUMENT                  TITLE                     PAGES
<S>                       <C>                       <C>

</Table>

<Page>

16.1.4    The Specifications are as described in SCHEDULE D attached hereto and
made a part hereof.
(EITHER  LIST THE  SPECIFICATIONS  HERE OR REFER TO AN EXHIBIT  ATTACHED TO THIS
AGREEMENT.)

<Table>
<Caption>
SECTION                   TITLE                     PAGE
<S>                       <C>                       <C>

</Table>

16.1.5    The Drawings are as described in SCHEDULE D attached hereto and made a
part hereof.
(EITHER LIST THE DRAWINGS HERE OR REFER LOAN EXHIBIT ATTACHED TO THIS AGREEMENT)

<Table>
<Caption>
NUMBER                    TITLE                     DATE
<S>                       <C>                       <C>

</Table>

16.1.6    The Addenda, if any, are as follows:

<Table>
<Caption>
NUMBER                    DATE                      PAGES
<S>                       <C>                       <C>
NONE
</Table>

Portions of Addenda relating to bidding requirements are not part of the
Contract Documents unless the bidding requirements are also enumerated in this
Article 16.

16.1.7    Other documents, if any, forming part of the Contract Documents are as
follows:
(LIST HERE ANY ADDITIONAL DOCUMENTS WHICH ARE INTENDED TO FORM PART OF THE
CONTRACT DOCUMENTS. THE GENERAL CONDITIONS PROVIDE THAT BIDDING REQUIREMENTS
SUCH AS ADVERTISEMENT OR INVITATION TO BID, INSTRUCTIONS TO BIDDERS, SAMPLE
FORMS AND THE CONTRACTOR'S BID ARE NOT PART OF THE CONTRACT DOCUMENTS UNLESS
ENUMERATED IN THIS AGREEMENT. THEY SHOULD BE LISTED HERE ONLY IF INTENDED TO BE
PART OF THE CONTRACT DOCUMENTS.)

The Following Schedules and Exhibits form part of the Contract Documents*:

Schedule A - 1  Construction Schedule
Schedule A - 2  Milestone Dates
Schedule B      Guaranteed Maximum Price Breakdown
Schedule C      GMP Qualifications and Assumptions
Schedule D      List of GMP Drawings and Specifications
Schedule E      Allowance Items
Schedule F      General Conditions Items
Schedule G      Contractor's Permitted Trade Work
Schedule H      Contractor's Hourly Wage Schedule
Schedule I      Key Persons
Schedule J      Alternates
Schedule K      Designated Subcontractors (Eligible for Early Release of
                Retainage)
Exhibit A       Contractor's Sworn Statement
Exhibit B       Contractor's Lien Waiver Form
Exhibit C       Subcontractor/Supplier Lien Waiver Form
Exhibit D       Procedures Manual
Exhibit E       Construction Management Plan

* Schedules and Exhibits to be provided upon request.

<Page>

This Agreement is entered into as of the day and year first written above and is
executed in at least three original copies of which one is to be delivered to
the Contractor, one to the Architect for use in the administration of the
Contract, and the remainder to the Owner.

OWNER                                     CONTRACTOR

/s/ Peter B. Calkins                      /s/ Jeffrey J. Corcoran
--------------------------------------    --------------------------------------
(SIGNATURE)                               (SIGNATURE)

(PRINTED NAME AND TITLE)                  (PRINTED NAME AND TITLE)
    Peter B. Calkins                         Jeffrey J. Corcoran
     Vice President                            Vice President<Page>

                                                                EXHIBIT NO. 10.9

          Confidential Materials omitted and filed separately with the
         Securities and Exchange Commission. Asterisks denote omissions.

                         NEW LONG TERM SUPPLY AGREEMENT

        This New Long Term Supply Agreement (the "Agreement") is entered into as
of the first (1st) day of January 2003, between Millennium Pharmaceuticals,
Inc., a company duly organized and existing under the laws of Delaware with
offices at 75 Sidney Street, Cambridge MA 02139, United States of America
("Millennium"), and Solvay, Societe Anonyme, a Belgian corporation with its
principal offices at 33, rue du Prince Albert, B-1050 Bruxelles, Belgium
("Solvay"), each on behalf of itself and its Affiliates. Millennium and Solvay
are sometimes referred to herein individually as a "Party" and collectively as
the "Parties" and references to "Millennium" and "Solvay" shall include their
respective Affiliates.

        WHEREAS,

        Millennium and Solvay are parties to a certain License and Supply
Agreement dated 27 July 1994 ("the License Agreement");

        Millennium and Solvay are also parties to a certain Long Term Supply
Agreement dated 28 September 1995, amended as per the First Amendment dated 1
April 1997 and assigned to Millennium as per the Assignment Agreement dated 12
February 2002 (the "Long Term Supply Agreement");

        Millennium and Solvay wish to cancel the Long Term Supply Agreement and
to replace it with this Agreement;

        NOW, THEREFORE, Millennium and Solvay agree as follows:

1 - CERTAIN DEFINITIONS

1.1     "AFFILIATES" shall mean any entity or person which controls, is
        controlled by or is under common control with either Party. For purposes
        of this Article 1.1, "control" shall mean (a) in the case of corporate
        entities, the direct or indirect ownership of at least one-half of the
        stock or participating shares entitled to vote for the election of
        directors, and (b) in the case of a partnership, the power to direct the
        management and policies of such partnership. Without limitation on the
        foregoing and for purposes of this Agreement, Peptisyntha, Societe
        Anonyme ("Peptisyntha"), which is a fully owned subsidiary of Solvay and
        a corporation existing under the laws of Belgium and having its
        principal offices at 310, rue de Ransbeek, B-1120 Bruxelles, Belgium, is
        deemed an Affiliate of Solvay.

<Page>

1.2     "BULK PRODUCT" shall mean a bulk peptide product which contains
        eptifibatide, is produced by the Licensed Process (as defined in the
        License Agreement) and is intended to undergo further processing,
        formulation and/or vialing and packaging.

1.3     "BULK PRODUCT INTERMEDIATES" shall mean [**] used to manufacture Bulk
        Product which have been partially processed.

1.4     "DELIVERY SCHEDULE" shall mean the delivery schedule agreed upon
        according to the provisions of Article 4.4 for delivery of Bulk Product
        to Millennium hereunder which may be reviewed according to the
        provisions of Article 9.8(b).

1.5     "DELIVERY SHORTFALL" shall mean the difference in grams, calculated at a
        given date of any year between

        (a)    the total quantity of Bulk Product which Solvay is committed to
               supply before said given date according to the Delivery Schedule
               for such year, and

        (b)    the total quantity of Bulk Product complying with the
               requirements of Article 8.2 delivered to Millennium during such
               year before said given date.

        A Delivery Shortfall shall be [**].

1.6     "EPTIFIBATIDE" shall refer to a specific peptide designated by
        Millennium and known as eptifibatide, which same peptide was known
        previously as Integrilin or Integrelin, the chemical structure of which
        is known to Solvay because of the prior business relationship between
        Millennium and Solvay.

1.7     "KEY RAW MATERIALS" shall mean the [**] reasonably required for the
        production of Bulk Product or Bulk Product Intermediates [**].

1.8     "MINIMUM ORDER" shall mean [**] kilograms of Bulk Product.

1.9     "ORDER SHORTFALL" shall mean the difference between the Minimum Order
        and the quantity ordered by Millennium for supply in any given year
        below the Minimum Order, expressed in grams.

1.10    "ORDER SURPLUS" shall mean the lesser of (i) the amount ordered by
        Millennium for supply in any given year in excess of the Minimum Order
        or (ii) [**] kilograms, expressed in grams.

1.11    "PRODUCTION CAPACITY" shall mean Solvay's capacity for manufacturing
        Bulk Product measured in kilograms of Bulk Product per year referred to
        in Article 2.1.

                                      - 2 -
<Page>

1.12    "PURCHASE ORDER" shall mean a purchase order or supplementary purchase
        order

        (a)    placed by Millennium according to the provisions of Article 4.4
               for production of Bulk Product by Solvay and supply thereof to
               Millennium according to the Delivery Schedule,

        (b)    acknowledged by Solvay according to the provisions of Article
               4.5, and

        (c)    which may be reviewed according to the provisions of Article
               9.8(b).

1.13    "REQUIREMENTS FORECASTS" shall mean the estimates of future requirements
        for Bulk Product to be manufactured by Solvay that are prepared by
        Millennium pursuant to Article 3.1.

1.14    "SPECIFICATION" shall mean the specification for Bulk Product as
        contained in Appendix C hereto and as may thereafter be amended in
        writing from time to time to reflect changes in such specifications.

Unless otherwise defined herein, other capitalized terms used herein shall have
the meaning specified in the License Agreement, as may be amended from time to
time. For convenience, this Agreement may refer to specific provisions or
appendices of the License Agreement. Defined terms may be used in their singular
or plural forms. Unless otherwise indicated, "year" shall mean a calendar year.

2 - PRODUCTION CAPACITY

2.1     CURRENT PRODUCTION CAPACITY. Solvay represents that its Production
        Capacity dedicated to the production of eptifibatide is [**] kilograms
        unless notified differently according to Articles 2.2 or 3.2.

2.2     PRODUCTION CAPACITY INCREASE. Solvay represents and Millennium
        acknowledges that decisions regarding substantial increase of the
        Production Capacity beyond the levels represented in Article 2.1 above
        need to be made [**]before the increase is effective. Therefore, on a
        timely basis, the Parties shall discuss the Requirements Forecasts and
        the implication of these forecasts on the need for increasing the
        Production Capacity. Solvay may however make incremental increases to
        such capacity [**] provided Millennium agrees to collaborate for
        handling some regulatory aspects. Should Solvay succeed in implementing
        such incremental capacity increase, it shall notify Millennium thereof
        and the current production capacity referred to in Article 2.1 would be
        updated accordingly.

                                      - 3 -
<Page>

3 - PRODUCTION PLANNING AND FORECASTS

3.1     REQUIREMENTS FORECASTS. Millennium shall provide Solvay with forecasts
        of its expected requirements for Bulk Product in accordance with Section
        2.2 of the License Agreement that are prepared in good faith and to the
        best of Millennium's knowledge at the time they are prepared. The
        Requirements Forecasts shall be consistent with the forecasts made by
        Millennium for requirements for eptifibatide worldwide, including sales
        to third parties, research quantities and appropriate inventory levels,
        and will cover [**]. The Requirements Forecasts [**] are appended hereto
        as Appendix A. Subsequent Requirements Forecasts shall be provided to
        Solvay on [**] of each year during the term of this Agreement, but
        Millennium may elect to provide such Requirements Forecasts more
        frequently. The Requirements Forecasts are provided for the purpose of
        programming, are not to be construed as Purchase Orders, and are not
        binding on Millennium or Solvay.

3.2     CHANGES TO THE SPECIFICATION. In the event that Millennium notifies
        Solvay of requested changes to the Specification, Solvay shall
        acknowledge receipt of such notice within a reasonable time, but in any
        event no later than [**], and Solvay will indicate the effect of such
        requested changes on Production Capacity and shall [**], as the case may
        be. After Millennium receives Solvay's response, if Millennium so
        requests, the Parties shall negotiate in good faith on such requested
        change to the Specification, which shall be subject to the mutual
        written agreement of both Parties, such agreement not to be unreasonably
        withheld or delayed.

3.3     PERSONNE DE CONFIANCE. Solvay agrees that Millennium may designate a
        "Personne de Confiance", who will be a Millennium employee or Millennium
        consultant. He or she shall have the mission to improve communication
        between Solvay and Millennium and to identify issues and facilitate
        their prompt resolution. Such mission shall consist of the following
        activities :

        - Review of planned and actual production and delivery schedules and
          activities

        - Review of planned and actual Bulk Product Intermediates purchasing
          from suppliers

        - Review of planned and actual inventories of Bulk Product Intermediates
          and Bulk Product

        - Review of status of technology transfer to the Secondary Source and
          potential additional sources

        - Review of issues affecting production and regulatory compliance

        - Review of plans for and status of plant expansion.

        Any additional activity is subject to Solvay's approval.

        Under appropriate confidentiality arrangements with Solvay, the
        "Personne de Confiance" will have access to the same information that
        could be communicated to any other Millennium personnel, except
        technology transfer agents (also referred to by the Parties as TTAs).
        However, the "Personne de Confiance" shall not have the power to make
        contractual commitments on behalf of Millennium, amend this Agreement or
        any other

                                      - 4 -
<Page>

        agreements between Millennium and Solvay or enter into any other
        agreements on behalf of Millennium without specific written
        authorization from Millennium.
        Millennium may change its designated "Personne de Confiance" as
        necessary, provided he or she signs a confidentiality agreement in
        substantially similar form to that signed by [**] dated October 10, 1996
        (a copy of which is attached hereto as Appendix D).

4 - PURCHASE ORDERS

4.1     PURCHASE COMMITMENT. Millennium agrees to purchase from Solvay and
        Solvay agrees to manufacture and supply to Millennium an amount of Bulk
        Product through Purchase Orders.

4.2     MINIMUM PURCHASE COMMITMENT. Millennium shall order from Solvay the
        Minimum Order of Bulk Product for delivery in the years 2004 and
        following during the term of this Agreement. In the event that
        Millennium orders less than such Minimum Order for delivery in any given
        year (referred to as the "Given Year" hereinafter in this Article 4.2),
        Millennium shall pay a penalty calculated by multiplying the Order
        Shortfall by [**] percent ([**]%) and by [**] for delivery in such Given
        Year calculated as set forth in Appendix B hereto taking paragraph (a)
        thereof as the reference price.

        Such penalty, which is subject to waiver in case of the occurrence of a
        Delivery Shortfall during the Given Year as provided for in the
        provisions of Article 9.8(c), shall be paid in [**] of said Given Year.
        Such penalty shall be Millennium's exclusive liability and Solvay's sole
        remedy for Millennium not ordering the Minimum Order.

        Notwithstanding the foregoing, the Order Shortfall shall be, for the
        purpose of calculating the penalty payment referenced above, reduced by
        the sum of:

        (a)    if Millennium has ordered more than the Minimum Order for
               delivery in the year preceding said Given Year (referred to as
               the "Previous Year" hereinafter in this Article 4.2), the Order
               Surplus for delivery in such Previous Year, and

        (b)    if the total quantity of Bulk Product delivered by Solvay at the
               end of the Previous Year is lower than the quantity ordered by
               Millennium for delivery in such Previous Year (such ordered
               quantity is not being subject to the deduction foreseen under
               Article 9.8(b)),

               (i)    if the total quantity of Bulk Product delivered by Solvay
                      at the end of said Previous Year is equal to or greater
                      than [**] grams, [**] grams, or

               (ii)   if the total quantity of Bulk Product delivered by Solvay
                      at the end of said Previous Year is lower than [**])
                      grams, [**] percent ([**]%) of the difference between [**]
                      and the total quantity of Bulk Product delivered by Solvay
                      accrued at the end of the Previous Year, expressed in
                      grams.

        The Parties acknowledge that, according to the above, the said Order
        Shortfall may be reduced to [**] but not below [**]. Any quantity taken
        into account to reduce said Order

                                      - 5 -
<Page>

        Shortfall for the purpose of calculating the penalty payment referenced
        above shall accordingly in no event exceed such Order Shortfall.

        In addition, Millennium agrees to pay to Solvay an amount in United
        States Dollars computed by multiplying that part of the Order Surplus
        which has been taken into account to reduce the Order Shortfall
        (expressed in grams) by the difference between

          -    the unit price applicable [**] for quantities [**] kilograms
               calculated as set forth in Appendix B hereto taking paragraph (a)
               thereof as the reference price, and

          -    the unit price applicable for [**] kilograms calculated as set
               forth in Appendix B hereto taking paragraph (b) thereof as the
               reference price.

        The said amount shall be paid by Millennium to Solvay [**].

4.3     SUPPLY COMMITMENT. Solvay shall accept purchase orders placed according
        to the provisions of Article 4.4 provided that the total amount of Bulk
        Product ordered for any year does not exceed its Production Capacity and
        shall supply such amount to Millennium according to the Delivery
        Schedule.

4.4     TIMING OF PURCHASE ORDERS AND DELIVERY SCHEDULE. [**] during the term of
        this Agreement, Millennium shall provide Solvay with a purchase order
        specifying the amount of Bulk Product that Millennium is ordering for
        the following year.

        For the sake of clarification, Millennium has no obligation hereunder to
        place orders for delivery beyond the term of this Agreement and Solvay
        has no obligation hereunder to accept Purchase Orders for delivery
        beyond the term of this Agreement.

        Promptly after receipt of such purchase order, Solvay shall provide
        Millennium with a delivery schedule specifying the dates at which Bulk
        Product shall be delivered. Each delivery shall consist, to the extent
        possible, [**] of approximately [**] kilograms. The Parties shall
        discuss in good faith for adjusting the delivery dates according to
        their own specific requirements, including the limitations resulting
        from the operation and maintenance of Solvay's currently existing
        manufacturing facilities, and such delivery schedule will be finalized
        and agreed upon in good faith.

        Millennium may elect to increase the amount it has ordered for a year by
        providing Solvay with a supplemental purchase order [**], which increase
        Solvay shall accept provided that the total amount does not exceed the
        lesser of (i) the Production Capacity or (ii) [**] percent ([**]%) of
        the amount of the Purchase Order placed [**].

        Upon receipt of such supplemental purchase order, the Parties shall
        discuss in good faith for reviewing the delivery schedule established
        earlier in the year according to their own specific requirements,
        including the limitations resulting from the operation and maintenance
        of Solvay's currently existing manufacturing facilities, and such
        delivery schedule will be finalized and agreed upon in good faith.

                                      - 6 -
<Page>

4.5     ACKNOWLEDGEMENT. Promptly after the Delivery Schedule is finalized
        according to the provisions of Article 4.4 [**], Solvay shall
        acknowledge in writing acceptance of a purchase order and supplemental
        purchase order placed by Millennium. The Delivery Schedule shall be
        attached to the acknowledgement document sent to Millennium.

5 - INVENTORIES AND STORAGE OF RAW MATERIALS AND BULK PRODUCT INTERMEDIATES

5.1     RAW MATERIALS INVENTORY. In addition to having available the amounts of
        Key Raw Materials required to accomplish the manufacture of the specific
        quantities of Bulk Products ordered by Millennium for each year during
        the term of this Agreement, Solvay will maintain an inventory of Key Raw
        Materials of not less than the amount necessary to meet [**] percent
        ([**]%) of the production scheduled for that year. The inventory will be
        maintained at a facility [**]. Such inventory shall be rotated first in,
        first out.

5.2     SUBCONTRACTING. Solvay may contract to [**], the manufacture of certain
        Bulk Product Intermediates provided however, that Solvay shall remain
        responsible and be guarantor of the performance by [**] and shall cause
        [**] to comply with the provisions of this Agreement in connection with
        such performance, including but not limited to the provisions of Article
        11.

5.3     BULK PRODUCT INTERMEDIATES INVENTORY. During the term of this Agreement,
        Solvay will maintain in inventory Bulk Product Intermediates
        manufactured up through certain manufacturing steps. To the extent
        possible, such inventory shall be rotated on a first in, first out
        basis, with Bulk Product Intermediates subsequently manufactured and
        scheduled for production through to final Bulk Product. Solvay shall
        retain samples of lots of each Bulk Product Intermediate to be used in
        the manufacture of Bulk Product until such Bulk Product has been
        manufactured, shipped to and accepted by Millennium. Millennium will be
        informed in writing by Solvay at least twice quarterly on the level of
        inventories of all Bulk Product Intermediates and on the scheduled
        production of Bulk Product Intermediates.

5.4     BULK PRODUCT INVENTORY. Solvay shall notify Millennium of the completion
        of the manufacture of each lot of final, purified Bulk Product.

5.5     DELIVERY. Subject to Article 6, Solvay shall make deliveries of Bulk
        Product to Millennium or Millennium's designee at the dates agreed upon
        in the Delivery Schedule of any Purchase Order according to the shipping
        procedures described in Article 8.1. Delay in delivery which may occur
        hereunder shall be subject to the provisions of Article 9.8.

5.6     POSTPONEMENT OF DELIVERY. Millennium shall have the right to request
        that the delivery of bulk product foreseen under Article 5.5 is
        postponed for a

                                      - 7 -
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        period [**]. in such event, Solvay shall put such undelivered bulk
        product into inventory at a facility [**] until it is delivered. such
        inventory shall be stored pursuant to Appendix C. [**] pursuant to
        [**] under this Article [**].

6 - QUALITY CONTROL AND REGULATORY MATTERS

6.1     SOLVAY'S MANUFACTURING COMMITMENT. Solvay shall manufacture Bulk Product
        under this Agreement in conformity with the Specification, in a duly
        licensed facility as required by the United States Food and Drug
        Administration and equivalent European Union regulatory agencies, and in
        compliance with applicable laws and regulations and Good Manufacturing
        Practices, as prescribed from time to time by these appropriate
        regulatory agencies. Each shipment of Bulk Product hereunder shall have
        been subjected to a quality control inspection by Solvay in accordance
        with the Specification and with Solvay's then current quality control
        standards and systems, which shall be at least as stringent as those
        agreed in writing between Millennium and Solvay. Solvay shall not make
        any change to its manufacturing process for the Bulk Product (as it
        exists as of the Effective Date) which would affect the regulatory
        approvals for the Bulk Product in the United States or the European
        Union (and to the extent applicable, of Member States of the European
        Union) without first obtaining the prior written approval of Millennium.
        Solvay shall number each shipment with a vendor lot number that is
        traceable to Key Raw Materials, Bulk Product Intermediates and/or other
        components used to manufacture such Bulk Product and shall maintain all
        appropriate validation documentation as reasonably specified by
        Millennium and agreed by Solvay, or as required by appropriate
        regulatory authorities. Such manufacturing and validation information
        shall be communicated to Millennium pursuant to Section 3.4 of the
        License Agreement. Solvay shall permit Millennium and/or representatives
        of appropriate regulatory agencies to review periodically Solvay's Bulk
        Product manufacturing facilities and testing procedures at reasonable
        times with a Solvay representative present, and to obtain copies of
        batch records for Bulk Product in order to assure compliance with the
        requirements of this Article 6.1.

6.2     COMPLIANCE WITH LAW. Solvay shall be responsible for complying with all
        applicable regulatory requirements of the United States, the European
        Union, and to the extent applicable, of Member States of the European
        Union, for the manufacture, importation and shipment of the Bulk Product
        supplied hereunder. Solvay shall give Millennium prompt written notice
        of any impending inspections by a governmental agency of the facility
        used for or processes involved in the manufacture of Bulk Product or
        Bulk Product Intermediates, and provide Millennium an opportunity to
        observe such inspection. Each Party shall promptly notify the other in
        writing of new instructions or specifications of which it becomes aware
        and governmental inspection reports which are relevant to the
        manufacture of Bulk Product or Bulk Product Intermediates under this
        Agreement and which are required by the United States Food and Drug
        Administration, equivalent European Union regulatory agencies, or other
        applicable laws or governmental regulations and shall confer with each
        other with respect to the best means to comply with such requirements.
        Solvay shall assist Millennium in obtaining and maintaining all
        approvals

                                      - 8 -
<Page>

        and authorizations of any governmental agencies necessary for the use,
        sale or distribution of eptifibatide products, and will notify
        Millennium [**] of any comments, responses or notices received from any
        governmental authorities which relate to the regulatory status of
        eptifibatide. These actions by Solvay shall not be construed as an
        admission that Solvay is doing business in the United States.

6.3     NOTIFICATION OF ISSUES. Solvay shall notify Millennium in writing [**]
        of any issue related to manufacturing or raw material supply, or other
        information relating to Solvay or the site(s) of manufacture which may
        affect the regulatory status of eptifibatide or the ability of Solvay to
        supply Bulk Product.

7 - SHIPPING AND ACCEPTANCE OF PRODUCT

7.1     PRODUCT SHIPPING PROCEDURES. Any shipment made hereunder shall be made
        with the proper identification on the packaging as required by
        applicable authorities and by this Agreement. Bulk Product will be
        labeled and packaged according to the Specification. Notwithstanding
        contrary provisions in the Specification, however, Bulk Product shall be
        packaged in a shipping container approved by Millennium [**]. Solvay
        shall [**]. In the event that Millennium specifies that the Bulk Product
        be shipped to a location other than Millennium's offices in South San
        Francisco (e.g., to a different location for product fill and finish),
        or in the event that Millennium's shipping request requires that the
        Bulk Product be placed into inventory [**], then upon Millennium's
        request, Solvay shall ship a quality control sample to Millennium's
        offices indicated above (or such other place as Millennium may
        designate) in advance of or not later than concurrently with the
        shipment of the Bulk Product or the placing of the Bulk Product into
        inventory. Except as provided herein with respect to non-conforming
        product or Bulk Product placed into inventory, title and risk of loss as
        to all Bulk Product shipped shall pass to Millennium or Millennium's
        designee [**]. In the event that, upon Millennium's request pursuant to
        Article 6, shipment of a lot of Bulk Product is not made promptly after
        the completion of manufacture of such lot and therefore such lot is
        placed into inventory, title shall pass to Millennium or Millennium's
        designee upon the delivery to inventory, but risk of loss shall remain
        with Solvay until such Bulk Product is delivered [**]. Solvay shall
        assist Millennium in arranging any desired insurance (in amounts that
        Millennium shall determine) and transportation [**], as the case may be.
        All customs, duties, costs, taxes, insurance premiums, and other
        expenses of such transportation and delivery (whether shipment of Bulk
        Product is made promptly after completion of manufacture or such Bulk
        Product is placed into inventory at Millennium's request), [**]. Solvay
        shall provide a packing list and a certificate of analysis to Millennium
        for every shipment and for every placing of the Bulk Product into
        inventory.

7.2     NON-CONFORMING AND NON-COMPLYING PRODUCT. Bulk Product supplied
        hereunder shall be produced by Solvay in compliance with all applicable
        laws and regulations of the United States, the European Union, and to
        the extent applicable, of Member States of the European Union, including
        without limitation current Good

                                      - 9 -
<Page>

        Manufacturing Practices as set forth in the United States Code of
        Federal Regulations, and in conformance with the Specification.
        Millennium may reject any shipment of Bulk Product which

        (a)    does not conform with the Specification or is not in compliance
               with such applicable laws and regulations, or

        (b)    is adulterated or misbranded within the meaning of the United
               States Federal Food, Drug and Cosmetic Act, equivalent European
               Union regulatory agency requirements, or other applicable laws or
               governmental regulations. Any notice of rejection of
               non-conforming product or notice that the product is adulterated
               or misbranded must be submitted to Solvay [**] after receipt by
               Millennium or its designee at the shipment destination designated
               by Millennium (and for the sake of clarification, when Bulk
               Product is placed in inventory, the Parties agree that such
               inventory is not a shipment destination designated by Millennium
               for the purposes of this Article 7.2), accompanied by a report of
               analysis (including a product sample from the lot analyzed)
               prepared according to the Specification. If no such notice of
               rejection of non-conforming product is submitted, Millennium
               shall be deemed to have accepted such delivery of the product.
               Product may be rejected as non-conforming based on analysis of a
               product sample shipped in advance of or concurrently with the
               full lot.

7.3     PROCEDURES AFTER NOTICE OF REJECTION. After notice of rejection of
        product is given in accordance with Article 7.2 above, Millennium shall
        cooperate with Solvay in determining whether rejection is necessary or
        justified. Solvay shall notify Millennium promptly whether or not it
        accepts Millennium's basis for any rejection. If Solvay disagrees with
        Millennium's determination that a certain product does not meet the
        requirements of Article 7.2 above, such product shall be submitted to a
        mutually acceptable third party laboratory; the fees and expenses of
        such laboratory testing shall be borne entirely by the Party against
        whom such findings are made. Such third party laboratory shall determine
        whether such product meets the requirements of Article 7.2 above and the
        Parties agree that such laboratory's determination shall be final and
        determinative. Whether or not Solvay accepts Millennium's basis for
        rejection, promptly on receipt of a notice of rejection of product,
        Solvay shall, at Millennium's request, use its best efforts to replace
        such rejected product. In the event that the rejected lot is determined
        to not meet the requirements of Article 7.2 above, any moneys paid for
        the rejected lot shall be returned to Millennium [**] after such
        rejection, unless the Parties agree on a schedule pursuant to which
        Solvay shall deliver a replacement lot. Bulk Product may only be
        reprocessed in accordance with validated reprocessing procedures
        described in the drug master file, as agreed by the Parties.
        Unless Solvay requests the destruction of rejected Bulk Product [**] of
        receipt of Millennium's notice of rejection of such Bulk Product,
        Millennium shall promptly return such Bulk Product to Solvay, [**], and
        according to shipping instructions in the Specification. Millennium
        shall, upon receipt of a request for destruction of the material,
        destroy such Bulk Product promptly, properly and at Solvay's expense,
        and provide Solvay with certification of such destruction. In the event
        the Bulk Product is rejected by

                                     - 10 -
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        Millennium on the basis of analysis of a product sample, Solvay shall
        retain the relevant lot of Bulk Product and treat it in the same fashion
        provided above.

7.4     GOVERNING TERMS. All sales hereunder shall be subject to the provisions
        hereof (including the Specification) and shall not be subject to the
        terms and conditions contained on any shipping request of Millennium or
        confirmation of Solvay, except insofar as any such shipping request or
        confirmation establishes :
        (a)    the quantity of any Bulk Product to be shipped;
        (b)    the agreed delivery date as set forth in the Delivery Schedule;
        (c)    the shipment route and destination; or
        (d)    the carrier.

8 - PRICE AND PAYMENTS

8.1     PRICES. Millennium agrees to pay to Solvay the prices for the
        manufacture of Bulk Product set forth in Appendix B. Applicable pricing
        shall be determined [**] in a particular year.

8.2     PRICE COMPUTATION. The payments to be made by Millennium to Solvay for
        the quantity of Bulk Product stated in a Purchase Order shall be
        computed by [**] such quantity by the [**] identified in Appendix B.

8.3     INVOICING AND PAYMENT. Payment for Bulk Product shall be made in the
        following increments :

        (a)    before the [**] of each year for Purchase Orders placed during
               that year, [**] percent ([**]%) of the applicable Bulk Product
               price specified in Appendix B multiplied by [**] stated in the
               applicable Purchase Order;

        (b)    within [**] of receipt of Solvay's written certification of the
               completion of the manufacture and delivery to Solvay's inventory
               of a lot of Bulk Product (if upon Millennium's request pursuant
               to Article 5.6 shipment is not made promptly after completion of
               the manufacture), or within[**] of receipt of Solvay's written
               certification of the completion of the manufacture and shipment
               of a lot of Bulk Product to Millennium or Millennium's designee,
               [**] percent ([**]%) of the applicable Bulk Product price
               specified in Appendix B multiplied by the [**] in that lot.

        However, in the event that [**], payment for Bulk Product shall be made
        in the following increments instead of the above:

        (a)    before [**] of each year for Purchase Orders placed during that
               year, [**] percent ([**]%) of the applicable Bulk Product price
               specified in Appendix B multiplied by [**] stated in the
               applicable Purchase Order, and

                                     - 11 -
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        (b)    within [**] of receipt of Solvay's written certification of the
               completion of the manufacture and delivery to Solvay's inventory
               of a lot of Bulk Product (if upon Millennium's request pursuant
               to Article 6 shipment is not made promptly after completion of
               the manufacture), or within [**] of receipt of Solvay's written
               certification of the completion of the manufacture and shipment
               of a lot of Bulk Product to Millennium or Millennium's designee,
               [**] percent ([**]%) of the applicable Bulk Product price
               specified in Appendix B multiplied by [**] in that lot.

8.4     METHOD OF PAYMENT. All payment shall be made in United States Dollars by
        wire transfer to the bank account of Solvay-CICC S.A. No. [**], or to
        such account of Solvay in such bank as Solvay may from time to time
        designate by notice to Millennium.

8.5     TAXES. Solvay shall be responsible for all value added taxes, property
        taxes, sales tax or any other such tax resulting from sales of Bulk
        Product to Millennium from Solvay or production of Bulk Product or
        purchase of any raw materials.

8.6     MILLENNIUM'S RIGHT TO VERIFY MANUFACTURE CERTIFICATION. Millennium shall
        have the right at its own expense to have an independent third party,
        acceptable to Solvay, audit Solvay's production records, during normal
        business hours and upon reasonable notice, for the purpose of verifying
        the manufacture of Bulk Product in accordance with this Agreement as
        certified pursuant to Article 7.2. Solvay's acceptance of the
        independent third party shall not be unreasonably withheld.

8.7     OVERDUE PAYMENT. Payments provided for in this Article 8, when overdue,
        shall bear interest at a rate per annum equal to two percentage points
        (2%) in excess of the one-year LIBOR effective at the date such payment
        is due, and for the time period until payment is made by Millennium.

8.8     DELIVERY SHORTFALL. In recognition of the fact that long term supply
        disruptions will affect the commercial viability of Millennium and
        eptifibatide, in the event that the Delivery Shortfall at any time
        during a given year (referred to as the "Given Year" hereinafter in this
        Article 8.8) is greater than [**] kilograms, or in the event that the
        Delivery Shortfall at the end of said Given Year is greater than [**]
        kilograms, the Parties shall discuss in good faith for setting up
        alternatives to remedy such Delivery Shortfall. If no alternative is
        deemed acceptable by Millennium, then

        (a)    Millennium shall have the right to have a quantity of Bulk
               Product up to the said Delivery Shortfall [**] and purchase such
               quantity (referred to as the "Quantity" hereinafter in this
               Article 8.8 and in Article 8.9) [**] of the License Agreement,

        (b)    the said Delivery Shortfall shall be deducted from the quantity
               of Bulk Product ordered by Millennium in the Purchase Order for
               delivery in said Given Year and the Delivery Schedule of said
               Purchase Order shall be amended by withdrawing the deliveries
               which Solvay was unable to make,

                                     - 12 -
<Page>

        (c)    if Millennium has ordered less than the Minimum Order for
               delivery in such Given Year, the penalty due by Millennium
               pursuant to Article 4.2 by reason of occurrence of an Order
               Shortfall for such Given Year shall be [**]; in the event that
               Millennium has already paid installments for such penalty during
               said Given Year, such installment payments shall be credited
               against future amounts due to Solvay hereunder except for the
               last year of the term of this Agreement for which Solvay shall
               reimburse Millennium in cash for such installment payments, and

        (d)    should Millennium exercise its right under paragraph 8.8(a) the
               Quantity purchased [**] shall not be taken into account to
               calculate for said Given Year (or for the [**], if such Quantity
               is delivered to Millennium [**]) the minimum [**]percent ([**]%)
               share of Millennium's total requirements of Bulk Product which
               Millennium is bound to purchase from Solvay pursuant to Section
               2.2 of the License Agreement.

8.9     [**]. For any year of the term of this Agreement for which Millennium
        orders from Solvay at least the Minimum Order and orders [**] Bulk
        Product [**], the royalty of [**] percent ([**]%) to be paid by
        Millennium to Solvay pursuant to Section 4.2 (a) and 4.2 (b) of the
        License Agreement shall be [**] percent ([**]%).

8.10    NOTIFICATION. [**] at any time during the term of this Agreement,
        Millennium shall immediately notify Solvay in writing thereof.

9 - TERM AND TERMINATION

9.1     TERM. This Agreement shall become effective as of 1 January 2003 in
        relation with the Bulk Product ordered for year 2004 and will continue
        subject to the provisions of Article 9.2 until 31 December 2007. This
        Agreement shall automatically renew thereafter [**]s unless either Party
        gives written notice to the other Party at least [**] prior to the
        beginning of such a renewal period that it does not wish to renew.

9.2    TERMINATION. This Agreement may be terminated:

        (a)    upon mutual written agreement between the Parties

        (b)    by either Party as a result of a material breach or default in
               the performance of any obligation, condition or covenant of this
               Agreement by the other Party, if such default or noncompliance
               shall not have been remedied, or steps initiated to remedy the
               same to the non-defaulting Party's reasonable satisfaction,
               within ninety (90) days after receipt by the defaulting Party of
               a notice thereof from the other Party, or

        (c)    by Millennium on notice of its receipt of a notice from a
               regulatory authority in the Unites States of America that
               eptifibatide is no longer approved for commercial sale, provided
               that such notice is delivered to Solvay at least twelve (12)
               months before termination becomes effective.

                                     - 13 -
<Page>

9.3     The termination of this Agreement shall not relieve the Parties from any
        of their obligations until the time of their fulfillment hereunder to
        the extent such obligations apply to Bulk Product ordered in a Purchase
        Order acknowledged by Solvay according to the provisions of Article 4.5
        or revised according to the provisions of Article 8.8(b) prior to the
        effective date of such termination, including but not limited to
        (a)    the obligation in Solvay to deliver said Bulk Product,
        (b)    the obligation in Millennium to accept and, upon acceptance, pay
               for any of said Bulk Product, and
        (c)    any other such obligation of either Party under Articles 6, 7,
               8, 9.3, 9.4, 10, 11, 12, and 13,

        Millennium's further payment of penalties, if any, pursuant to Article
        4.2 above for not meeting the minimum purchase commitments in such
        Article 4.2 for the year in which this Agreement is terminated in
        accordance with Section 9.2(c) above shall be reduced on a pro-rata
        basis to reflect the exact date of termination during such year.
        Termination shall not limit Millennium's right to sell eptifibatide
        produced from Bulk Product in its possession or delivered to it after
        such termination. Termination of this Agreement shall not affect the
        License Agreement except as provided for in Article 9.4(a).

9.4     In the event that SOLVAY exercises its right under Article 9.1 to
        terminate the automatic renewal of this Agreement after its initial
        term,

        (a)    the [**] percent ([**]%) share of Millennium's total, worldwide
               requirements of Bulk Product which Millennium is required to
               purchase from Solvay under Section 2.2 of the License Agreement
               shall be reduced to [**] percent ([**]%), and

        (b)    both Parties shall negotiate in good faith another agreement for
               supply of Bulk Product by Solvay to Millennium [**] under the
               Long Term Supply Agreement dated 28 September 1995 before its
               termination.

10 - INDEMNIFICATION, LIABILITY AND RECALLS

10.1    MILLENNIUM INDEMNIFICATION. Millennium shall indemnify, defend and hold
        Solvay and Solvay Affiliates harmless from and against all costs,
        claims, suits, expenses (including reasonable attorneys' fees) and
        damages arising out of or resulting from :

        (a)    the use by or administration to any person of eptifibatide
               (except where such cost, claim, suit, expense or damage arose or
               resulted from Solvay's negligence or willful misconduct, or an
               event specified in Article 10.2); or

        (b)    infringement of any third party intellectual property rights
               relating to eptifibatide but not to the manufacture of Bulk
               Product;

        provided that Solvay gives prompt notice in writing to Millennium of any
        such claim or action, gives Millennium sole control and authority with
        respect to the defense and

                                     - 14 -
<Page>

        settlement of such claim or action to Millennium, assists Millennium if
        requested by Millennium at Millennium's expense in defending such claim
        or action and does not compromise or settle such claim or action without
        Millennium's prior written consent. Millennium shall not accept any
        settlement which imposes liability on Solvay not covered by this
        indemnification or restrictions on Solvay without Solvay's prior written
        consent, which consent shall not be unreasonably withheld or delayed.

10.2    SOLVAY INDEMNIFICATION. Solvay shall indemnify, defend and hold
        Millennium harmless from and against all costs, claims, suits, expenses
        (including reasonable attorneys' fees) and damages arising out of or
        resulting from :

        (a)    any failure of the Bulk Product supplied by Solvay under this
               Agreement to meet the Specification;

        (b)    any failure of Solvay to manufacture the Bulk Product in
               accordance with Good Manufacturing Practices or any other
               applicable government law or regulation; and

        (c)    infringement of any third party intellectual property right
               relating to the manufacture, use or sale of Bulk Product but not
               to eptifibatide independent of its manufacture;

        provided that Millennium gives prompt notice to Solvay of any such claim
        or action, offers to give Solvay sole control and authority with respect
        to the defense and settlement of such claim or action to Solvay, assists
        Solvay if requested by Solvay at Solvay's expense in defending such
        claim or action, and does not compromise or settle such claim or action
        without Solvay's prior written consent. Solvay shall not accept any
        settlement which imposes liability on Millennium not covered by this
        indemnification or restrictions on Millennium without Millennium's prior
        written consent, which consent shall not be unreasonably withheld or
        delayed.

10.3    LIMITATION OF LIABILITY. Subject to Solvay's obligations under Articles
        10.2(c) and 10.4 and other than for fraudulent misrepresentation, death
        or personal injury caused by Solvay's negligent or willful acts,
        Solvay's liability to Millennium under this Agreement shall be limited
        to the free (to Millennium) replacement of Bulk Product within a
        reasonable time, or the value thereof, provided that the information
        Solvay originally submitted to Millennium about the batch of Bulk
        Product and the manufacture of same was accurate. Neither Party shall be
        liable to the other for indirect, incidental or consequential damages
        arising out of any of the terms or conditions of this Agreement or with
        respect to its performance.

10.4    RECALLS. Solvay will indemnify and hold Millennium harmless from the
        costs of Bulk Product recalled and up to [**] U.S. dollars ($ [**] U.S.)
        for any out-of-pocket expense relating to implementation of a recall of
        any batch of Bulk Product supplied by Solvay due to failure to meet the
        warranties set forth in Article 11.1 below. For purposes of this
        Agreement, the expenses of recall shall be the expenses of notification
        and destruction or return of the recalled Bulk Product, and any costs
        directly associated with the distribution

                                     - 15 -
<Page>

        of replacement Bulk Product. Millennium shall have the right to control
        the arrangement of any recall, and the Parties will cooperate with each
        other in implementing such recall.

11 - WARRANTIES

11.1    SOLVAY WARRANTIES. Solvay warrants :

        (a)    that it will comply with all manufacturing instructions and the
               Specification, including quality control standards provided in
               accordance with this Agreement;

        (b)    that Bulk Product will be produced in accordance with such
               instructions and specifications and with Good Manufacturing
               Practices and other applicable laws, rules and regulations of the
               United States, the European Union, and to the extent applicable,
               of European Union Member States; and

        (c)    that, upon delivery of Bulk Product [**], Bulk Product will be in
               conformity with the Specification and with the United States
               Food, Drug and Cosmetic Act, providing , inter alia, that the
               Bulk Product shall not be adulterated or misbranded or otherwise
               of a nature which may not be introduced into United States
               interstate commerce.

11.2    NO OTHER WARRANTIES. THE EXPRESS WARRANTIES MADE IN THIS AGREEMENT AND
        THE LICENSE AGREEMENT ARE IN LIEU OF ALL OTHER WARRANTIES, EXPRESS OR
        IMPLIED, INCLUDING, WITHOUT LIMITATION, THE WARRANTIES OF
        MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE.

12 - GENERAL PROVISIONS

12.1    COMPLAINTS. Solvay will report to Millennium in writing any complaints
        and any information that it may receive relating to eptifibatide.

12.2    NOTICES. All notices and demands required or permitted to be given or
        made pursuant to this Agreement shall be in writing and shall be deemed
        given if delivered personally or be given by facsimile transmission
        (receipt verified), mailed by registered or certified mail (return
        receipt requested), postage prepaid, or sent by express courier service
        (receipt verified), properly addressed to the address of the Party to be
        notified as shown below :

        IF TO SOLVAY :
        The General Manager of Solvay Peptides
        SOLVAY S.A.
        310, rue de Ransbeek

                                     - 16 -
<Page>

        B - 1120 Bruxelles, Belgium
        Facsimile: 32-2-264-3470

        IF TO MILLENNIUM :
        Millennium Pharmaceuticals, Inc.
        Vice President of Commercial Manufacturing
        One Broadway
        Cambridge, Massachusetts 02142
        United States of America
        Facsimile: 1-617-621-0264

        With a copy to :
        Millennium Pharmaceuticals, Inc.
        General Counsel
        One Broadway
        Cambridge, Massachusetts 02142
        United States of America
        Facsimile : 1-617-374-0074

        or to such other address as to which either Party may notify the other.
        Any notice sent by facsimile transmission shall be followed within
        twenty-four (24) hours by a signed notice sent by first class mail,
        postage prepaid.

12.3    ASSIGNMENT AND DELEGATION. Solvay may not assign its rights and/or
        delegate its obligations under this Agreement to any third party without
        the prior written consent of Millennium, such consent not to be
        unreasonably withheld, except in connection with the sale, merger or
        transfer of substantially all of the stock or assets of Solvay or the
        sale, merger or transfer of substantially all of the interests in or the
        assets of Peptisyntha to any party who meets financial and ethical
        standards generally acceptable within the pharmaceutical industry,
        providing that such assignee or delegatee agrees to be bound by the
        terms of this Agreement, in which case the consent of Millennium is not
        required. Millennium may assign its rights hereunder in whole or part,
        or delegate any of its obligations hereunder to any party who meets
        financial and ethical standards generally acceptable within the
        pharmaceutical industry, except without such requirement of standards in
        connection with the sale, merger or transfer of all or substantially all
        of the assets of Millennium relating to eptifibatide, provided such
        assignee or delegatee agrees to be bound by the terms of this Agreement.

12.4    PERFORMANCE BY AFFILIATES. The Parties recognize that each may perform
        some or all of its obligations under this Agreement through Affiliates
        as specified in this Agreement, provided however, that each Party shall
        remain responsible and be guarantor of the performance by its Affiliates
        and shall cause its Affiliates to comply with the provisions of this
        Agreement in connection with such performance.

                                     - 17 -
<Page>

12.5    PERFORMANCE BY THIRD PARTIES. The Parties recognize that Solvay may
        perform some or all of its manufacture and storage obligations under
        this Agreement through a third party, with the prior written consent of
        Millennium, such consent not to be unreasonably withheld. [**]. Solvay
        shall remain responsible and be guarantor of the performance by third
        parties performing its obligations hereunder and shall cause such third
        parties to comply with the provisions of this Agreement in connection
        with such performance.

12.6    GOVERNING LAW. This Agreement shall be governed by and construed in
        accordance with the laws of England; excluding: (i) its conflicts of
        laws principles; and (ii) the United Nations Convention on Contracts for
        the International Sale of Goods. Solvay and Millennium submit
        irrevocably to the exclusive jurisdiction and venue of the English
        courts.

12.7    FORCE MAJEURE. Neither Party shall be liable to the other for loss or
        damage, or, except as provided herein, have any right to terminate this
        Agreement by virtue of an occurrence which prevents, delays or
        interferes with the performance by a Party of any of its obligations
        hereunder, if such occurs by reason of any Act of God, flood, fire,
        explosion, casualty or accident, or war, revolution, civil commotion,
        acts of public enemies, blockage or embargo, or any law, order or
        proclamation of any government, strike or other labor trouble, failure
        of suppliers to deliver materials, equipment or machinery, interruption
        of or delay in transportation, or any other cause whatsoever, whether
        similar or dissimilar to those above enumerated, beyond the reasonable
        control of such Party, if, and only if, the Party affected shall have
        used its best efforts to avoid such occurrence ; PROVIDED, HOWEVER, that
        the occurrence of a force majeure event shall [**]. In such an event,
        the Party affected shall notify the other and shall attempt to perform
        its obligations as soon as possible.

12.8    ENTIRE AGREEMENT. With respect to the manufacture and supply of Bulk
        Product for year 2004 and thereafter, this Agreement together with the
        License Agreement is the entire agreement between the Parties and shall
        terminate and supersede any prior written or oral promises or
        representations between the Parties not incorporated herein including
        the Long Term Supply Agreement dated September 28, 1995. For the sake of
        clarification, the Parties acknowledge that the termination of such Long
        Term Supply Agreement does not relieve the Parties from those of their
        obligations which survive such termination as provided for in Article
        9.3 thereof, including but not limited to
        (a)    the obligation in Solvay to deliver Bulk Product ordered by
               Millennium in the purchase orders here below which were placed
               before said termination
               (i)    purchase order N DEG. 1077633 ([**] kg) from Millennium
                      dated [**], and
               (ii)   purchase order N DEG. P20395 ([**] kg) from Cor
                      Therapeutics [**], and
        (b)    the obligation in Millennium to pay for Bulk Product delivered by
               Solvay.

        In addition, Solvay agrees to deliver to Millennium an amount of [**]
        kilograms of Bulk Product in 2003 in addition to the quantities ordered
        in the purchase orders referred to here above, [**].

                                     - 18 -
<Page>

        In the event of conflict between this Agreement and the License
        Agreement, the terms of the License Agreement shall control except for
        the provisions of Article 8.8(a), 8.8(d), 8.9 and 9.4(a) which shall
        prevail, and such provisions shall be deemed to supplement and amend the
        License Agreement for the period for which such provisions are in force
        hereunder. No amendment or modification of the terms of this Agreement
        shall be binding on either Party unless reduced to writing and signed by
        the respective authorized officers of the Parties.

12.9    SEVERABILITY. If any provision of this Agreement is determined to be
        illegal or unenforceable by any court of law or any competent
        governmental or other authority, the remaining provisions shall be
        severable and enforceable in accordance with their terms so long as this
        Agreement with such terms or provisions does not fail of its essential
        purpose. The Parties shall negotiate in good faith to replace any such
        illegal or unenforceable provisions with suitable substitute provisions
        which will maintain as far as possible the purposes and the effect of
        this Agreement.

12.10   RELATIONSHIP OF THE PARTIES. Nothing in this Agreement is intended or
        shall be deemed to constitute a partnership, agency, employer-employee
        or joint venture relationship between the Parties. All activities by the
        Parties hereunder shall be performed by them as independent contractors.
        Neither Party shall incur any debts or make any commitments for the
        other Party, except to extent, if at all, specifically provided herein.
        No right, express or implied, is granted by this Agreement to either
        Party to use in any manner the name of the other or any other trade name
        or trade mark of the other in connection with the performance of this
        Agreement. Solvay shall not, without first obtaining the written consent
        of Millennium, in any manner disclose or publish the terms of this
        Agreement.

12.11   WAIVER. Failure of either Party to insist upon strict observance of or
        compliance with any of the terms of this Agreement in one or more
        instances shall not be deemed to be a waiver of its rights to insist
        upon such observance or compliance with the other terms hereof, at that
        point in time or in the future.

12.12   HEADINGS. All headings, titles and captions in this Agreement are for
        convenience only and shall not be of any force or substance.

12.13   COUNTERPARTS. This Agreement may be executed in multiple counterparts,
        each of which shall be an original, but all of which shall constitute
        but one agreement.

13 - INSURANCE

13.1    INSURANCE REQUIREMENTS. Solvay shall secure and maintain in full force
        and effect throughout the term of this Agreement and for at least three
        (3) years thereafter, public and private insurance with coverage and
        minimum policy limits set forth as follows :

                                     - 19 -
<Page>

        (a)    WORKER'S COMPENSATION, including coverage for occupational
               disease, with benefits determined by statute, in at least the
               amounts required by applicable law.

        (b)    COMPREHENSIVE GENERAL LIABILITY, PERSONAL/ADVERTISING INJURY and
               PRODUCT LIABILITY, including coverage for contractual liability
               assumed by Solvay and coverage for Solvay's independent
               contractor(s), with an aggregate limit of at least twenty million
               U.S. dollars ($ 20,000,000 U.S.).

        (b)    COMPREHENSIVE AUTOMOBILE LIABILITY, including coverage for owned,
               hired, and non-owned automobiles in at least the amounts required
               by applicable law.

        (d)    "ALL RISK" property policy, valued at replacement cost, covering
               loss or damage to manufacturing facilities engaged in the
               manufacture of Bulk Product or Bulk Product Intermediates under
               this Agreement and Millennium's property and materials in the
               care, custody, and control of Solvay.

13.2    PROOF OF INSURANCE. Solvay shall furnish to Millennium a certificate
        from an insurance carrier (having a minimum Standards & Poor's rating of
        A) demonstrating the amounts of insurance set forth above have been
        satisfied as of the date of such certificate. The insurance certificate
        shall confirm each of the following:

        (a)    excluding Solvay's Worker's Compensation policy, Millennium is
               named as an additional insured with respect to matters arising
               from this Agreement;

        (b)    such insurance is primary and non-contributing to any liability
               insurance carried by Millennium; and

        (c)    thirty (30) days prior written notice shall be given to
               Millennium in the event of cancellation or any material change in
               the policies or in the matters covered in Sections 13.2(a) and
               13.2(b) above.

13.3    INSPECTIONS. Solvay shall comply, at Millennium's expense, with
        reasonable requests for information made by Millennium's insurance
        provider representative(s) by permitting such representative(s) to
        inspect manufacturing facilities engaged in the manufacture of Bulk
        Product or Bulk Product Intermediates under this Agreement during
        operational hours with a minimum one month prior notice to Solvay. In
        regard to such inspections, the representative(s) shall adhere to such
        guidelines and policies pertaining to safety and non-disclosure as
        Solvay may require.

                                     - 20 -
<Page>

IN WITNESS WHEREOF, the Parties hereto have executed this Agreement to be
effective on the date first set forth above.

<Table>
<S>                                     <C>
            MILLENNIUM                                 SOLVAY S.A.
       PHARMACEUTICALS INC.

BY    :   /s/ John M. Nystrom           BY    :  /s/ Pierre Barthelemy
         -------------------------               --------------------------
TITLE :   V.P. MANUFACTURING            TITLE :   GENERAL MANAGER SOLVAY PEPTIDES
          KENNETH M. BATES, CFO                  /s/ Jurgen Ernst, DIRECTOR AND MEMBER OF
                                                 THE EXECUTIVE COMMITTEE; GENERAL MANAGER
                                                 PHARMACEUTICALS SECTOR SOLVAY

DATE  :   19 December 2002              DATE :    18 December 2002
         -------------------------               -----------------------
</Table>

Appendix A : Requirements Forecasts
Appendix B : Bulk Product Price
Appendix C : Bulk Product Specification (with letter from Peptisyntha dated
December 10, 2002 attached)
Appendix D : Confidentiality Agreement signed by [**] dated 10 October 1996

                                     - 21 -
<Page>

                       APPENDIX A : REQUIREMENTS FORECASTS

                                 [**] [**] [**]

                                     - 22 -
<Page>

                         APPENDIX B : BULK PRODUCT PRICE

The reference price for Bulk Product at the Specification, [**], as the case may
be, shall be :

     (a)  for quantities ordered in any given year up to and including [**]
          United States Dollars (USD [**])

     (b)  for quantities ordered in any given year in excess of [**] United
          States Dollars (USD [**])

The unit price for Bulk Product shall be computed by multiplying the
above-specified reference price by two corrective factors determined in the
following manner:

        (i)    [**] corrective factor: divide the value of [**] as of the date
               of the relevant Purchase Order by [**] from that ratio, [**], and
               then [**] to that product to identify the factor.

        (ii)   [**] corrective factor: [**] as of the date of the Purchase
               Order, [**], and then [**] to that product to identify the
               factor.

[**], as of the date of the Purchase Order, [**].

                                     - 23 -
<Page>

SOLVAY
--------------------------------------------------------------------------------
DIRECTION CENTRALE RECHERCHE & TECHNOLOGIE

From:  P. Barthelemy

                                               Mr. John Nystrom
                                               MILLENNIUM Pharmaceuticals Inc.
                                               One Broadway
                                               USA - CAMBRIDGE, MA 02142
                                               United States of America

PEPTI - PBY/CCI                                Brussels, December 10, 2002

BY DHL

Dear John,

In relation with our discussions on the New Long Term Supply Agreement, with the
Specifications attached as Appendix C, [**].

I herewith confirm that [**] in the final Bulk Product.

Best regards,

                                               For SOLVAY S.A.

                                               /s/ Pierre Barthelemy

                                               Pierre BARTHELEMY
                                               General Manager Solvay Peptides

                                     - 24 -
<Page>

                                   APPENDIX C

                           Bulk Product Specification

I - BULK PRODUCT CONTENT AND TESTING

<Table>
<Caption>
TEST LOT        TEST         SPECIFICATION         METHOD
--------        ----         -------------         ------
<S>             <C>          <C>                   <C>
[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]
</Table>

-------------------------
  1 [**].

  2 [**].

  3 [**].

[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]

[**]            [**]         [**]                  [**]

                                     - 25 -
<Page>

II - SHIPPING SPECIFICATION FOR SHIPMENT OF BULK PRODUCT TO MILLENNIUM

[**] containing Bulk Product will be packed in a molded (Styrofoam) container
along with dry ice inside a cardboard shipper. The outside of the cardboard
shipper will be labeled "Refrigerate Upon Arrival". Shipments will be made [**]
The commercial invoice and certificate of analysis will accompany the shipment.
The commercial invoice will specify the harmonized code : 2934.99.3000 "Drugs".
Shipments should be made via [**](in San Francisco) or their local agent in
Brussels. Before the shipment is sent, Solvay will telefax the commercial
invoice and details of the impending shipment to MILLENNIUM and to [**]. The
Bulk Product will be shipped such that the Port-of-Entry into the United States
is San Francisco. The shipment will be sent to :

        MILLENNIUM Pharmaceuticals
        Attention QA/QC
        256 East Grand Avenue
        South San Francisco, California 94080 - USA

                                     - 26 -
<Page>

III - DESCRIPTION OF THE METHODS

The table below lists the Peptisyntha Test Procedure numbers for the analytical
methods that will be used for the release of Eptifibatide Bulk Product. The
method numbers referenced below and their respective procedures may only be
changed by mutual agreement of MILLENNIUM and Solvay.

<Table>
<Caption>
METHOD                PEPTISYNTHA METHOD NUMBER
------                -------------------------
<S>                   <C>
[**]                  [**]
[**]                  [**]
[**]                  [**]
[**]                  [**]
[**]                  [**]
[**]                  [**]
[**]                  [**]
[**]                  [**]
[**]                  [**]
[**]                  [**]
[**]                  [**]
[**]                  [**]
[**]                  [**]
</Table>

IV - REFERENCE STANDARDS

For the purpose of Eptifibatide Bulk Product release testing. Peptisyntha will
use a reference standard that has been either provided by MILLENNIUM.

                                     - 27 -
<Page>

                                   APPENDIX D

                            CONFIDENTIALITY AGREEMENT

This Agreement is entered into effective as of October 10, 1996 among:

SOLVAY, SOCIETE ANONYME ("SOLVAY"), a Belgian corporation, with its principal
offices at 33, rue du Prince Albert, 1050 Brussels, Belgium, on behalf of itself
and its Affiliates; and

COR THERAPEUTICS, INC. ("COR"), a Delaware corporation, with its principal
offices at 256 East Grand Avenue, South San Francisco, California 94080, USA, on
behalf of itself and its Affiliates; and

[**] ("RECIPIENT"), a designee of COR with an address at [**].

WITNESSETH

WHEREAS, COR owns certain patent rights, trademarks and know-how relating to a
product called INTEGRILIN(TM),

WHEREAS, SOLVAY has developed a unique and valuable patented and proprietary
process useful for the manufacture of peptides, and is practicing the said
process for the manufacture of bulk peptide products containing INTEGRILIN sold
to COR pursuant to several Agreements entered into between SOLVAY and COR.

WHEREAS, SOLVAY has agreed to disclose confidential information to the RECIPIENT
who has been duly appointed as "Homme de Confiance" by COR with responsibility
for coordination of certain communications between COR and PEPTISYNTHA, an
Affiliate of SOLVAY, such

                                     - 28 -
<Page>

mission being described in the APPENDIX hereof and being subject to updating
from time to time by SOLVAY and COR.

NOW, THEREFORE, in consideration of the foregoing and the mutual promises
contained herein, the parties agree as follows:

1.0 - CERTAIN DEFINITIONS

For the purposes of this Agreement, the following terms shall have the following
meanings:

1.1    "AFFILIATES" shall mean any entity or person which controls, is
        controlled by or is under common control with either Party. For purposes
        of this section 1.1., "control" shall mean:

        (a)    in the case of corporate entities, the direct or indirect
               ownership of at least one-half of the stock or participating
               shares entitled to vote for the election of directors, and

        (b)    in the case of a partnership, the power to direct the management
               and policies of such partnership.

        Without limitation on the foregoing and for purposes of this Agreement,
        PEPTISYNTHA & Cie, Societe en Nom Collectif ("PEPTISYNTHA"), which is a
        fully owned subsidiary of SOLVAY and an entity existing under the laws
        of Belgium and having its principal offices at 310, rue de Ransbeek,
        1120 Brussels, Belgium, is deemed an Affiliate of SOLVAY.

1.2    "AGREEMENT PURPOSE" shall. mean the fulfillment by RECIPIENT of the
        mission of "Homme de Confiance" he has been entrusted with and which is
        described in the APPENDIX hereof.

1.3    "SOLVAY CONFIDENTIAL INFORMATION" shall mean any or all information
        disclosed by SOLVAY to RECIPIENT in order to enable him to fulfill the
        Agreement Purpose as well as any and all information that RECIPIENT may
        learn or have access to, due to his presence in SOLVAY's or
        PEPTISYNTHA's facilities, relating to SOLVAY's or PEPTISYNTHA's business
        or technology.

1.4    "EFFECTIVE DATE" shall mean October 10, 1996.

1.5    "INTEGRILIN" shall mean a specific peptide designated by COR and known
        as INTEGRILINtm, the chemical structure of which is known to RECIPIENT
        pursuant to the terms of separate agreements entered into with COR.

                                     - 29 -
<Page>

1.6    "PARTY" shall mean SOLVAY, COR or RECIPIENT.

2 - DISCLOSURE OF SOLVAY CONFIDENTIAL INFORMATION

2.1     SOLVAY shall disclose to RECIPIENT SOLVAY Confidential Information
        sufficient to enable RECIPIENT to fulfill the Agreement Purpose.

2.2     SOLVAY Confidential Information disclosed under paragraph 2.1 hereabove
        maybe disclosed in tangible form, such as in writing and marked
        "Confidential", or provided orally.

3 - CONFIDENTIALITY AND EXCEPTIONS

3.1     RECIPIENT hereby agrees, regarding SOLVAY Confidential Information
        disclosed to him by SOLVAY under the terms of Article 2 hereof that he
        shall

        (a)    make no use of said information, except for the Agreement
               Purpose;

        (b)    not disclose said information to any party or person, except to
               COR's employees duly appointed to receive it;

        (c)    not disclose to any party or person either the existence of this
               Agreement or its underlying discussions except for the Agreement
               Purpose;

        (d)    take the same steps to protect said information as he takes to
               protect the proprietary and confidential information of COR.

3.2     RECIPIENT hereby agrees, regarding SOLVAY Confidential Information he
        may learn or have access to due to his presence in SOLVAY's or
        PEPTISYNTHA's facilities and which is not comprised in the Confidential
        Information referred to in Article 2 hereof; that he shall:

        (a)    make no use, of said information, except for the Agreement
               Purpose;

        (b)    not disclose said information to any party or person;

        (c)    not disclose to any party or person either the existence of this
               Agreement or its underlying discussions except for the Agreement
               Purpose;

        (d)    take the same steps to protect said information as he takes to
               protect the proprietary and confidential information of COR.

                                     - 30 -
<Page>

3.3     The obligations under paragraph 3.1 and 3.2 hereabove shall not,
        however, apply to any SOLVAY Confidential Information which:

        (a)    RECIPIENT can prove is at the time of disclosure or thereafter
               becomes public knowledge through no fault or negligence of
               RECIPIENT, or

        (b)    RECIPIENT can prove was known to him, prior to the receipt of
               such Confidential Information from SOLVAY, or

        (c)    is lawfully obtained by RECIPIENT from any party not bound by a
               secrecy obligation towards SOLVAY relating to the Confidential
               Information.

        For the purposes of this paragraph 3.3, information shall not be deemed
        to be public , knowledge or known on the ground only that

                 (i)   the general principle is public knowledge or known to
                       RECIPIENT if the particular practice is not itself public
                       knowledge or so known, or

                 (ii)  it constitutes a combination of or is drawn from
                       information which is public knowledge or known to
                       RECIPIENT unless the combination itself and its principle
                       and mode of operation is also public knowledge or known
                       to the RECIPIENT.

4.0 - DOCUMENTS DELIVERY OR DESTRUCTION

Upon the written request of SOLVAY, RECIPIENT undertakes to promptly deliver it,
or destroy if so instructed by it, all documents furnished by SOLVAY to
RECIPIENT and constituting Confidential Information, as well as all copies
thereof which might be in his possession.

5.0 - NO IMPLIED LICENSE

Nothing in this Agreement shall be construed as to grant RECIPIENT any title or
right or license to own or use at any time the SOLVAY Confidential Information,
except as expressly set forth herein.

6.0 - COR'S RESPONSIBILITY

COR shall guarantee the performance of this Agreement by RECIPIENT.

                                     - 31 -
<Page>

7.0 - TERM

This Agreement shall become effective on the Effective Date and shall remain in
effect until terminated by any Party. The provisions of Article 3 shall however
survive until the thirty-first day of December 2030.

8.0 - GENERAL PROVISIONS

8.1    NOTICES

All notices and demands required or permitted to be given or made pursuant to
this Agreement shall be in writing and shall be deemed given if delivered
personally or by given facsimile transmission (receipt verified), telexed,
mailed by registered or certified mail (return receipt requested), postage
prepaid, or sent by express courier service, properly addressed to the address
of the Party to be notified as shown below:

        If to SOLVAY

               SOLVAY S.A.
               DCR-LC
               310, rue de Ransbeek
               B - 1120 Brussels, Belgium
               ATTENTION:  GENERAL MANAGER RESEARCH AND DEVELOPMENT

        If to COR

               President, COR Therapeutics, Inc.
               256 East Grand Avenue
               South San Francisco, California 94080, USA

        If to RECIPIENT

               [**]

or to such other address as to which any Party may notify the others. Any notice
sent by facsimile transmission or telex shall be followed within twenty-four
(24) hours by a signed notice sent by first class mail, postage prepaid.

8.2     ASSIGNMENT AND DELEGATION

RECIPIENT may not assign his rights and/or delegate his obligations under this
Agreement to any third party without the prior consent of SOLVAY and COR.

8.3     AMENDMENT

                                     - 32 -
<Page>

No amendment or modification of the terms of this Agreement shall be binding on
any Party unless reduced to writing and signed by the respective authorised
officers of SOLVAY and COR and by RECIPIENT.

8.4     PUBLICITY

The Parties agree that, except as may otherwise be required by applicable laws,
regulations, rules or orders, no information concerning this Agreement and the
transactions contemplated herein shall be made public by any Party without the
prior written consent of the others.

8.5     WAIVER

Failure of any Party to insist upon strict observance of or compliance with any
of the terms of this Agreement in one or more instances shall not be deemed to
be a waiver of its rights to insist upon such observance or compliance with the
other terms hereof, at that point in time or in the future.

8.6     COUNTERPARTS

This Agreement may be executed in multiple counterparts, each of which shall be
an original, but all of which shall constitute but one agreement.

8.7     GOVERNING LAW

This Agreement shall be governed by the laws of England. SOLVAY, COR and
RECIPIENT consent to the exclusive jurisdiction and venue of the Courts of
England.

IN WITNESS THEREOF, the parties hereto have executed this Agreement, in three
original copies.

SOLVAY S.A.                                    COR THERAPEUTICS, INC.

By: /s/ A. Hoffait                             By: /s/ Mark D. Perrin
    -----------------------------                  -----------------------------
    A. Hoffait                                 Mark D. Perrin
Title: General Manager, Research and           Title:  Executive Vice President,
       Development Commercial Operations

                                    RECIPIENT

                                    /s/ [**]
                                ----------------
                                      [**]

                  APPENDIX: Mission of the "Homme de Confiance"

                                     - 33 -
<Page>

                                                                        APPENDIX

                       MISSION OF THE "HOMME DE CONFIANCE"

The mission of the "Homme de Confiance" aims at improving communications between
SOLVAY and COR and at facilitating prompt resolution of issues between them.

The mission will include the following activities

-    Review of production and delivery schedules and activities;
-    Review of Intermediates purchasing from suppliers and Intermediates and
     Bulk Products inventories;
-    Review of status of technology transfer to the Secondary Source and
     potential additional sources;
-    Review of outstanding issues affecting production and regulatory
     compliance;
-    Review of plans for and status of Plant Expansion.

Any additional activity, within the scope of COR's letter dated October 6, 1996
attached, is subject to SOLVAY's approval.

                                       ---

                                     - 34 -
<Page>

[COR LOGO]

                             COR THERAPEUTICS, INC.

                                                           256 E. Grand Avenue
                                                           South San Francisco
                                                           California 94080
                                                           415 2446800
                                                           Fax 415 244 9208

October 6, 1996

Mr. Alfred Hoffait
General Manager, Research & Development Solvay, S.A.
Rue de Ransbeek 310
B-1120 Brussels, Belgium

Dear Alfred:

This letter serves to clarify any issues regarding [**] level of confidentiality
and access to information from COR's perspective. As "homme de confiance", COR
views [**] as a COR representative in frequent attendance at Solvay, and as
such, we would like him to have access to the same information that could be
communicated to any other COR personnel.

[**] has entered into a confidentiality arrangement with COR, and therefore this
letter specifically authorizes you to show [**] confidential COR information
that may be in your files, and to discuss with him any issues regarding the
relationship between COR and Solvay.

It is our hope that involving [**] in COR/Solvay issues on a regular basis will
improve communications between our companies and facilitate prompt resolution of
issues. However, you understand that [**] is not COR's general agent and he does
not have the power to commit COR or enter into agreements on behalf of COR
without specific instructions from COR.

We appreciate your willingness to include [**] as a representative of COR.

Regards,

/s/Mark D. Perrin
Mark D. Perrin
Executive Vice President, Commercial Operations

                                     - 35 -
<Page>

               AMENDMENT NO. 5 TO THE LICENSE AND SUPPLY AGREEMENT

        This Amendment, effective as of the thirty first (31st) day of December
2002, is by and between

        SOLVAY S.A., a company duly organized and existing under the laws of
Belgium with offices at 33, rue du Prince Albert, B-1050 Bruxelles, Belgium,
acting on behalf of itself and its AFFILIATES (as hereinafter defined),
hereinafter globally referred to as "SOLVAY",

        and

        MILLENNIUM Pharmaceuticals, Inc., a company duly organized and existing
under the laws of Delaware with offices at 75 Sidney Street, Cambridge, MA
021139, hereinafter referred to as "MILLENNIUM."

RECITALS

COR (AS HEREINAFTER DEFINED) AND SOLVAY ARE THE PARTIES TO A CERTAIN LICENSE
AND SUPPLY AGREEMENT.

COR HAS ASSIGNED TO MILLENNIUM SAID LICENSE AND SUPPLY AGREEMENT PER THE
ASSIGNMENT AGREEMENT DATED 12 FEBRUARY 2002.

SOLVAY AND MILLENNIUM ARE WILLING TO MODIFY A PROVISION OF SAID LICENSE AND
SUPPLY AGREEMENT.

OPERATIVE PROVISIONS

       ARTICLE 1. DEFINITIONS

               1.1 Whenever used in this Agreement, the following terms written
               in capital letters shall have the following meaning:

               a) AFFILIATES shall have the same meaning as in the LICENSE
               AGREEMENT.

               b) COR shall mean COR THERAPEUTICS, Inc., a company duly
               organized and existing under the laws of Delaware with offices at
               256 East Grand Avenue, South San Francisco, California, USA
               94080.

               c) LICENSE AGREEMENT shall mean the License and Supply
               Agreement dated 27 July 1994 entered into between SOLVAY and COR
               and amended as per

<Page>

               (i) the First Amendment dated 13 March 1995,

               (ii) the Second Amendment dated 1 June 1995,

               (iii) the Third amendment dated 5 September 1995, and

               (iv) the Fourth Amendment dated 1 April 1997.

               1.2 Unless the indicated otherwise, references to Sub-Clauses
               shall mean references to Sub-Clauses of this Agreement.

       ARTICLE 2. - AMENDMENT

               2.1 Section 2.2 of the LICENSE AGREEMENT shall be deleted and
               replaced by the following Section 2.2:

SECONDARY SUPPLY.
-----------------

        COR shall have the right to establish a Secondary Source for the
        manufacture of Bulk Product by the Licensed Process for COR The
        Secondary Source shall be selected from the list of specific potential
        secondary sources acceptable to COR and to Solvay which is attached
        hereto as Exhibit C; this list may be amended from time to time upon
        agreement of COR and Solvay, such agreement not to be unreasonably
        withheld, and without any additional fee. COR and Solvay agree that a
        potential corporate partner, such as one of those exemplified in Exhibit
        C, would be acceptable as the Secondary Source. COR will notify Solvay
        of the establishment of the Secondary Source. In the event COR
        terminates a supply arrangement with a Secondary Source, COR may
        establish an alternate Secondary Source. COR shall notify Solvay [**] of
        such a termination of supply arrangements with a Secondary Source.
        Further, after the Secondary Source is established, COR may use [**] for
        the manufacture of Bulk Product starting from Step One Intermediates
        supplied by Solvay to [**]. COR's future requirements for Bulk Product
        cannot be ascertained with certainty at the present time, however, COR
        wants to entertain certain minimum purchase obligations. Therefore,
        after the Secondary Source is established, COR shall be required to
        purchase from Solvay a share of at least [**] percent ([**]%) of its
        total, worldwide requirements for Bulk Product on a year-to-year basis
        (to the extent that such share does not exceed the manufacturing
        capacity planned by Solvay to produce Bulk Product) for the time period
        during which royalties are payable under this Agreement, except to the
        extent the parties have agreed otherwise in writing. For purposes of the
        preceding sentence, such planned capacity shall be determined for a
        particular calendar year X on the [**]. Notwithstanding the above
        however, COR may purchase from such Secondary Source and/or [**] percent
        ([**]%) of its requirements in the event of any breach or default of
        Solvay of any supply arrangement between COR and Solvay for so long as
        the breach or default remains uncured. In the event Solvay assigns or
        transfers to a third party the Licensed Process, this Agreement, the
        Supply Agreement or the Long Term Supply Agreement, inconsistently with
        the terms of these Agreements, COR may establish and additional,
        "Back-up" Secondary Source for the manufacture of Bulk Product. In the
        event that COR wishes to establish COR itself either as the

                                        2
<Page>

        Secondary Source or the Back-up Secondary Source, then COR and Solvay
        shall negotiate in good faith, before establishing COR in such capacity,
        a method for establishing [**].

               b) All the other provisions of the LICENSE AGREEMENT shall remain
               unchanged and in full force and effect.

               c) The present amendment shall be effective as of the first date
               here above written.

        IN WITNESS HEREOF, the parties have caused this Agreement to be executed
in two original copies by their duly authorized representatives, as of the date
first above written.

SOLVAY S.A.                                  MILLENNIUM PHARMACEUTICALS INC.

Name:  /s/ Jurgen Ernst                      Name: /s/ John M. Nystrom
       ---------------------                       -------------------------
Title: Director and Member of                Title: VP - Manufacturing
       the Executive Committee
       General Manager Pharmaceuticals Sector
       SOLVAY

Pierre Barthelemy
General Manager
Solvay Peptides

Date:  18 December 2002                      Date: 19 December 2002 8:18 AM EST
       ----------------                            -----------------------------

Sign:                                        Sign:
       -----------------------------              ------------------------------

                                        3

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