Document:

Exhibit 4.1

 

Execution Version

 

 

 

SECOND Supplemental
Indenture

 

by
and among

 

PROTALIX
BIOTHERAPEUTICS, INC., as Issuer,

AND
EACH OF THE GUARANTORS PARTY HERETO,

and

 

The
Bank of New York Mellon Trust CoMPANY, N.A., as Trustee,

 

dated as of November 27, 2017

to the Indenture, dated as of December 7,
2016,

as supplemented by the First Supplemental
Indenture, dated as of July 24, 2017

relating to 7.50% Senior Secured Convertible Notes due
2021

 

  

     

     

    

 

SECOND Supplemental
Indenture

 

SECOND SUPPLEMENTAL INDENTURE, dated as
of November 27, 2017 (this “Second Supplemental Indenture”), by and among PROTALIX BIOTHERAPEUTICS, INC., a
Delaware corporation (the “Company”), as issuer, the Guarantors party hereto, and The Bank of New York Mellon
Trust Company, N.A., as Trustee, registrar, paying agent and conversion agent, under an Indenture, dated as of December 7, 2016,
by and among the Company, each of the guarantors party thereto, Wilmington Savings Fund Society, FSB, as collateral agent, and
the Trustee (the “Base Indenture”), as supplemented by the First Supplemental Indenture, dated July 24, 2017
(the “First Supplemental Indenture”). All capitalized terms used in this Second Supplemental Indenture and not
otherwise defined herein have the meanings given to the terms in the Base Indenture and the First Supplemental Indenture.

 

WHEREAS, on December 7, 2016, the Company
duly authorized the creation of an issue of $62,686,000 aggregate principal amount of the Company’s 7.50% Senior Secured
Convertible Notes due 2021 (the “Notes”) pursuant to the Base Indenture;

 

WHEREAS, on July 24, 2017, the Company entered
into a note purchase agreement relating to the issuance and sale by the Company of Additional Notes in the aggregate principal
amount of $10,000,000, and for that purpose, entered into the First Supplemental Indenture;

 

WHEREAS, Sections 9.02, 9.03, 9.04 and 9.05
of the Base Indenture provide that the Company may enter into this Supplemental Indenture;

 

WHEREAS, the Company and the Guarantors
desire to amend Section 10.07 of the Base Indenture as set forth in Section 1.1 below;

 

WHEREAS, the Trustee is authorized to execute
and deliver this Second Supplemental Indenture;

 

WHEREAS, the Company and the Guarantors
have requested and hereby request that the Trustee join with the Company and the Guarantors in the execution and delivery of this
Second Supplemental Indenture and the Company and the Guarantors have provided the Trustee with (a) Board Resolutions authorizing
the execution of and approving this Second Supplemental Indenture. (b) pursuant to Section 1.04 of the Base Indenture, Acts of
Holders evidencing the written consent of the Holders of at least a majority of the aggregate principal amount of the Notes outstanding
to the execution and delivery of this Second Supplemental Indenture and (c) an Officers’ Certificate and an Opinion of Counsel
stating that this Second Supplemental Indenture is authorized and permitted under the Indenture and the other Note Documents; and

 

WHEREAS, all requirements necessary to make
this Second Supplemental Indenture a valid instrument in accordance with its terms have been performed, and the execution and delivery
of this Second Supplemental Indenture has been duly authorized in all respects.

 

NOW, THEREFORE, in consideration of the
foregoing and for other good and valuable consideration, the receipt of which is hereby acknowledged, the Company, the Guarantors
and the Trustee mutually covenant and agree as follows:

 

     

     

    

 

		SECTION 1.1	Amendment to Indenture.

 

The Indenture is hereby amended pursuant
to Section 9.02 of the Base Indenture by replacing Section 10.07 of the Base Indenture in its entirety with the following:

 

“Shares to Be Fully
Paid. The Company shall at all times provide, free from preemptive rights, out of its authorized, unreserved (for other issuances)
and unissued shares or shares held in treasury, sufficient shares of Common Stock to provide for conversion of the Notes and settlement
of the Make-Whole Obligation (assuming (w) all outstanding Notes would be converted by a single Holder, (x) Physical Settlement
were applicable to the conversion of the Notes and settlement of the Make-Whole Obligation, (y) no Additional Shares were added
to the Conversion Rate pursuant to Section 10.04 and (z) settlement of the Make-Whole Obligation were to require delivery of the
maximum number of shares of Common Stock that may be deliverable upon Physical Settlement of the Make-Whole Obligation, assuming
calculation of the Make-Whole Premium using a discount rate of 0% and a Conversion Make-Whole Share Price equal to 150% of the
then-current Conversion Price). The Company shall settle any Conversion Obligation and Make-Whole Obligation by Cash Settlement
if the number of shares of Common Stock deliverable upon settlement thereof under Physical Settlement would exceed the Company’s
authorized, unreserved (for other issuances) and unissued shares or shares held in treasury.”

 

		SECTION 1.2	Ratification of Indenture.

 

(a)           The Base Indenture, as supplemented by the First Supplemental Indenture and this Second Supplemental Indenture, is in all
respects ratified and confirmed, and this Second Supplemental Indenture shall be deemed part of the Base Indenture in the manner
and to the extent herein and therein provided.

 

(b)           Each party hereto hereby acknowledges and agrees that before and after giving effect to this Second Supplemental Indenture
all terms, conditions, provisions and covenants in the Security Documents shall remain unaltered and in full force and effect,
except as expressly modified or waived hereby. Each party hereto hereby confirms and agrees that to the extent any Security Document
purports to grant, assign or pledge to the Collateral Agent or any other Person a security interest or Lien on any Collateral as
security for the obligations secured by the Security Documents, such grant, assignment or pledge is hereby ratified and confirmed
in all respects.

 

		SECTION 1.3	Governing Law.

 

This Second Supplemental Indenture and each
Note shall be deemed to be a contract made under the internal laws of the State of New York, and for all purposes shall be construed
in accordance with laws of said State.

 

     

     

    

 

		SECTION 1.4	Separability.

 

In case any one or more of the provisions
contained in this Second Supplemental Indenture or in the Notes shall for any reason be held invalid, illegal or unenforceable
in any respect, such invalidity, illegality or unenforceability shall not affect any other provisions of this Second Supplemental
Indenture or of the Notes, but this Second Supplemental Indenture and the Notes shall be construed as if such invalid or illegal
or unenforceable provision had never been contained herein or therein.

 

		SECTION 1.5	Counterparts.

 

This Second Supplemental Indenture may be
executed in any number of counterparts each of which shall be an original; but such counterparts shall together constitute but
one and the same instrument. The exchange of copies of this Indenture and of signature pages by facsimile or PDF transmission shall
constitute effective execution and delivery of this Indenture as to the parties hereto and may be used in lieu of the original
Indenture for all purposes. Signatures of the parties hereto transmitted by facsimile or PDF shall be deemed to be their original
signatures for all purposes.

 

SECTION 1.6        Effect of Headings. The Section headings in this Second Supplemental Indenture are for convenience only and shall
not affect the construction hereof.

 

SECTION 1.7        Responsibility
for Recitals, Etc. The recitals and statements in this Second Supplemental Indenture shall be taken as the statements of the
Company, and the Trustee and the Holders party hereto assume no responsibility for the correctness thereof. The Trustee and the
Holders party hereto make no representations as to the validity, adequacy or sufficiency of this Second Supplemental Indenture.

 

SECTION 1.8        TIA Controls. If any provision of this Second Supplemental Indenture limits, qualifies or conflicts with another
provision which is required to be included in this Second Supplemental Indenture by the TIA, the provision required by the TIA
shall control.

 

[Signature Page Follows]

 

     

     

    

 

IN WITNESS WHEREOF, the parties hereto have
caused this Second Supplemental Indenture to be duly executed by their authorized respective officers as of the day and year first
above written.

 

	Date: December 1, 2017	PROTALIX BIOTHERAPEUTICS, INC., as Issuer
	 	 	 	 
	 	By: 	Yossi Maimon	 
	 	 	Name: 	Yossi Maimon	 
	 	 	Title: 	CFO
	 	 	 	 
	Date: December 1, 2017	THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as Trustee
	 	 	 	 
	 	By: 	R. Tarnas	 
	 	 	Name: 	R. Tarnas	 
	 	 	Title: 	Vice President

 

	PROTALIX LTD., as Guarantor	 
	 	 	 	 
	By: 	Yossi Maimon	 	 
	 	Name: 	Yossi Maimon	 	 
	 	Title: 	CFO	 
	 	 	 	 
	PROTALIX B.V., as Guarantor	 
	 	 	 	 
	By: 	Yossi Maimon	 	 
	 	Name: 	Yossi Maimon	 	 
	 	Title: 	CFOEX-4.2

 Exhibit 4.2 

THIRD SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”), dated as of November 30, 2017, between NiSource Inc., a
Delaware corporation (“NiSource”), and The Bank of New York Mellon, a New York banking corporation, not in its individual capacity but solely as successor trustee (the “Trustee”) under the Indenture dated as of
February 14, 1997 among NiSource Capital Markets, Inc., an Indiana corporation formerly known as NIPSCO Capital Markets, Inc. (“NiSource Capital Markets”), NiSource, as successor to NIPSCO Industries, Inc., and The Chase
Manhattan Bank, as original trustee (as supplemented, the “Indenture”). 
 W I T N E S S E T H 

WHEREAS, NiSource Capital Markets and NiSource executed and delivered to the Trustee (as successor in interest to JPMorgan Chase Bank, N.A.,
formerly known as The Chase Manhattan Bank) the Indenture in order to provide for the issuance from time to time of NiSource Capital Markets’ unsecured debentures, notes or other evidences of indebtedness (collectively, the
“Securities”), subject to the Support Agreement described below, to be issued in one or more series as might be determined by NiSource Capital Markets under the Indenture in an unlimited aggregate principal amount, which may be
authenticated and delivered as provided in the Indenture; 
 WHEREAS, NiSource executed and delivered a Support Agreement, dated
April 4, 1989, as amended (the “Support Agreement”), with NiSource Capital Markets, pursuant to which NiSource agreed to ensure the timely payment of principal of (and premium, if any) and interest on Debt (as defined in the
Support Agreement), subject to certain limitations; 
 WHEREAS, Section 801 of the Indenture permits NiSource Capital Markets to merge
with or into another Person, provided that, among other things, the Person into which NiSource Capital Markets is merged expressly assumes (i) the due and punctual payment of the principal of (and premium, if any) and interest on all the
Securities and (ii) the performance of every covenant of the Indenture to be performance or observed on the part of NiSource Capital Markets; 

WHEREAS, Section 802 of the Indenture provides, among other things, that upon any merger in accordance with Section 801, the
surviving entity shall succeed to, and be substituted for, and may exercise every right and power of, NiSource Capital Markets under the Indenture with the same effect as if such successor had been named as NiSource Capital Markets therein. 

WHEREAS, Section 901(1) of the Indenture provides, among other things, that the Indenture may be supplemented without the consent of
any Holders of Securities in order to evidence the succession of another entity to NiSource Capital Markets and the assumption by such successor of the covenants of NiSource Capital Markets in the Indenture and in the Securities; 

WHEREAS, effective as of the date hereof, NiSource Capital Markets has merged with and into NiSource (the “Merger”), and, as
the surviving corporation in the Merger, NiSource is responsible for all the debts, liabilities and duties of NiSource Capital Markets, including under the Indenture and the Securities; 

 WHEREAS, as a result of the Merger and NiSource’s succession to all the obligations of
NiSource Capital Markets under the Indenture, the provisions of the Indenture relating to the Support Agreement have become redundant and unnecessary; 

WHEREAS, NiSource desires and has requested that the Trustee join in the execution of this Supplemental Indenture for the purpose of
evidencing NiSource’s assumption of the obligations of NiSource Capital Markets; 
 WHEREAS, the execution and delivery of this
Supplemental Indenture has been authorized by resolutions of the board of directors of NiSource; and 
 WHEREAS, all conditions precedent
and requirements necessary to make this Supplemental Indenture a valid and legally binding instrument in accordance with its terms have been complied with, performed and fulfilled, and the execution and delivery hereof has been in all respects duly
authorized. 
 NOW THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt and adequacy of
which is hereby acknowledged, NiSource and the Trustee mutually covenant and agree for the benefit of each other and the equal and ratable benefit of the Holders of Securities as follows: 

ARTICLE 1 
 DEFINITIONS

 Section 1.1    Defined Terms. As used in this Supplemental Indenture, terms defined in the Indenture
or in the preamble or recitals hereto are used as so defined. The words “herein,” “hereof” and “hereby” and other words of similar import used in this Supplemental Indenture refer to this Supplemental Indenture as a
whole and not to any particular section hereof. 
 ARTICLE 2 

REPRESENTATIONS, WARRANTIES AND AGREEMENTS OF NISOURCE 

Section 2.1    NiSource represents, warrants and agrees as follows: 

(a)    It is a corporation duly organized, validly existing and in good standing under the laws of Delaware. 

(b)    The execution, delivery and performance by it of this Supplemental Indenture has been authorized and approved by
all necessary corporate or other action on its part, and this Supplemental Indenture is its valid and legally binding obligation, enforceable against it in accordance with its terms. 

(c)    The Merger has become effective on the date hereof. 

  
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 (d)    The Indenture, as supplemented by this Supplemental Indenture, shall
remain in full force and effect in accordance with its terms immediately after the execution of this Supplemental Indenture. 
 ARTICLE 3

 ASSUMPTION AND AGREEMENTS 

Section 3.1    NiSource hereby assumes the due and punctual payment of the principal of (and premium, if any) and
interest on all the Securities and the performance of every covenant of the Indenture to be performed or observed on the part of NiSource Capital Markets. 

Section 3.2    NiSource shall succeed to, and be substituted for, and may exercise every right and power of, NiSource
Capital Markets under the Indenture and the Securities, with the same effect as if NiSource had been named as NiSource Capital Markets therein. 

ARTICLE 4 
 SUPPORT
AGREEMENT 
 Section 4.1    The Indenture shall be amended to remove Section 803 (Assumption by
Industries or Subsidiary), Exhibit A (Support Agreement), Section 312 (Support Agreement) and Section 1011 (Support Agreement), each in its entirety, to remove all cross-references to such Sections and Exhibit in
the Indenture and to remove all other references to the Support Agreement and NiSource’s obligations under the Support Agreement in the Indenture. 

Section 4.2    The separate rights, powers, covenants, agreements and obligations in the Indenture applicable to
NiSource solely pursuant to its obligations under the Support Agreement shall be extinguished, and NiSource shall hereafter have only the rights, powers, covenants, agreements and obligations that, prior to the Merger, applied to NiSource Capital
Markets, provided that references in the Indenture to “Industries” shall be retained to the extent necessary to avoid adverse consequences to the Holders of Securities. 

ARTICLE 5 
 MISCELLANEOUS

 Section 5.1    Execution and Delivery. This Supplemental Indenture shall be effective upon execution
by the parties hereto. 
 Section 5.2    Ratification of Indenture; Supplemental Indenture Part of
Indenture. Except as expressly amended hereby, the Indenture is in all respects ratified and confirmed and all the terms, conditions and provisions thereof shall remain in full force and effect. This Supplemental Indenture shall form a part of
the Indenture for all purposes, and every Holder of Securities heretofore or hereafter authenticated and delivered shall be bound hereby. 

Section 5.3    Severability. In case any provision in this Supplemental Indenture shall be invalid, illegal or
unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby and such provision shall be ineffective only to the extent of such invalidity, illegality or unenforceability.

  
 - 3 - 

 Section 5.4    Governing Law. THIS SUPPLEMENTAL INDENTURE SHALL
BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE INTERNAL LAW OF THE STATE OF NEW YORK, WITHOUT GIVING EFFECT TO ANY CONTRARY CONFLICT OF LAWS OR CHOICE OF LAW PROVISIONS OF THE LAW OF THE STATE OF NEW YORK OR ANY OTHER JURISDICTION. 

Section 5.5    Waiver of Jury Trial. EACH OF NISOURCE AND THE TRUSTEE HEREBY IRREVOCABLY WAIVES, TO THE
FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THE INDENTURE, THE SECURITIES OR THE TRANSACTIONS CONTEMPLATED HEREBY. 

Section 5.6    Counterparts. The parties may sign any number of copies of this Supplemental Indenture
(including by electronic transmission). Each signed copy shall be an original, but all of them together represent the same agreement. The exchange of copies of this Supplemental Indenture and of signature pages by facsimile or PDF transmission shall
constitute effective execution and delivery of this Supplemental Indenture as to the parties hereto and may be used in lieu of the original Supplemental Indenture for all purposes. Signatures of the parties hereto transmitted by facsimile or PDF
shall be deemed to be their original signatures for all purposes. 
 Section 5.7    Effect of Headings. The
Section headings herein are for convenience only and shall not affect the construction hereof. 

Section 5.8    Trustee. The Trustee shall not be responsible in any manner whatsoever for or in respect of the
validity or sufficiency of this Supplemental Indenture or for or in respect of the recitals contained herein, all of which recitals are made solely by NiSource. 

[Signature page follows] 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed as of the day and year first above written. 
  

			
	NISOURCE INC.
		
	By:	 	 /s/ Donald E. Brown

	Name:	 	Donald E. Brown
	Title:	 	Executive Vice President and Chief Financial Officer

 Attest: 
  

			
	By:	 	 /s/ Samuel K. Lee

		 	Samuel K. Lee
		 	Vice President and Corporate Secretary

  

			
	THE BANK OF NEW YORK MELLON, as Trustee
		
	By:	 	 /s/ Laurence J. O’Brien

	Name:	 	Laurence J. O’Brien
	Title:	 	Vice President

 Attest: 
  

			
	By:	 	 /s/ Latoya S. Elvin

		 	Latoya S. Elvin
		 	Vice President

  
 [Signature Page to
Third Supplemental Indenture]

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