Document:

VENTURE
LOAN AND SECURITY AGREEMENT

 

Dated
as of June 27, 2018

by
and among

 

HORIZON
TECHNOLOGY FINANCE CORPORATION,

a
Delaware corporation

312
Farmington Avenue

Farmington,
CT 06032

 

as
a Lender and Collateral Agent

 

And

 

CELSION
CORPORATION,

a
Delaware corporation

997
Lenox Drive, Suite 100

Lawrenceville,
NJ 08648

 

as
Borrower

 

Loan
A Commitment Amount: $2,500,000

Loan
B Commitment Amount: $2,500,000

Loan
C Commitment Amount: $2,500,000

Loan
D Commitment Amount: $2,500,000

 

	 	Loan
    A Commitment Termination Date:	June
    29, 2018
	 	 	 
	 	Loan
    B Commitment Termination Date:	June
    29, 2018
	 	 	 
	 	Loan
    C Commitment Termination Date:	June
    29, 2018
	 	 	 
	 	Loan
    D Commitment Termination Date:	June
    29, 2018

 

    	 

    	 

    

 

The
Lender, Collateral Agent and Borrower hereby agree as follows:

 

AGREEMENT

 

1.
Definitions and Construction.

 

1.1
Definitions. As used in this Agreement, the following capitalized terms shall have the following meanings (such meanings
to be equally applicable to both the singular and plural forms of the terms defined):

 

“Account
Control Agreement” means an agreement acceptable to Lender which perfects via control Lender’s and Collateral
Agent’s security interest in Borrower’s deposit accounts and/or securities accounts.

 

“Affiliate”
means, with respect to any Person, any other Person that owns or controls directly or indirectly ten percent (10%) or more of
the stock of another entity of such Person, any other Person that controls or is controlled by or is under common control with
such Person and each of such Person’s officers, directors, managers, joint venturers or partners. For purposes of this definition,
the term “control” of a Person means the possession, direct or indirect, of the power to direct or cause the direction
of the management and policies of such Person, whether through the ownership of voting Equity Securities, by contract or otherwise
and the terms “controlled by” and “under common control with” shall have correlative meanings.

 

“Agreement”
means this certain Venture Loan and Security Agreement by and among Borrower, Collateral Agent and Lender dated as of the date
on the cover page hereto (as it may from time to time be amended, modified or supplemented in a writing signed by Borrower, Collateral
Agent and Lender).

 

“Anti-Terrorism
Laws” means any laws relating to terrorism or money laundering, including Executive Order No. 13224 (effective September
24, 2001), the USA PATRIOT Act, the laws comprising or implementing the Bank Secrecy Act, and the laws administered by OFAC.

 

“Borrower”
means Borrower as set forth on the cover page of this Agreement.

 

“Business
Day” means any day that is not a Saturday, Sunday, or other day on which banking institutions are authorized or required
to close in Connecticut or New Jersey.

 

“Claim”
has the meaning given such term in Section 10.3 of this Agreement.

 

“Code”
means the Uniform Commercial Code as adopted and in effect in the State of Connecticut, as amended from time to time; provided
that if by reason of mandatory provisions of law, the creation and/or perfection or the effect of perfection or non-perfection
of the security interest in any Collateral is governed by the Uniform Commercial Code as in effect in a jurisdiction other than
the State of Connecticut, the term “Code” shall also mean the Uniform Commercial Code as in effect from time to time
in such jurisdiction for purposes of the provisions hereof relating to such creation, perfection or effect of perfection or non-perfection.

 

    	1

    	 

    

 

“Collateral”
has the meaning given such term in Section 4.1 of this Agreement.

 

“Collateral
Agent” means Horizon, or any successor collateral agent appointed by Lender.

 

“Commitment
Amount” means the Loan A Commitment Amount, the Loan B Commitment Amount, the Loan C Commitment Amount or the Loan D
Commitment Amount, as applicable.

 

“Commitment
Fee” has the meaning given such term in Section 2.6(c) of this Agreement.

 

“Consolidated”
means the consolidation of accounts in accordance with GAAP.

 

“Default”
means any Event of Default or any event which with the passing of time or the giving of notice or both would become an Event of
Default hereunder.

 

“Default
Rate” means the per annum rate of interest equal to five percent (5%) over the Loan Rate, but such rate shall in no
event be more than the highest rate permitted by applicable law to be charged on commercial loans in a default situation.

 

“Disclosure
Schedule” means Exhibit A attached hereto.

 

“Environmental
Laws” means all foreign, federal, state or local laws, statutes, common law duties, rules, regulations, ordinances and
codes, together with all administrative orders, directed duties, requests, licenses, authorizations and permits of, and agreements
with, any Governmental Authorities, in each case relating to environmental, health, safety and land use matters, including the
Comprehensive Environmental Response, Compensation and Liability Act of 1980, the Clean Air Act, the Federal Water Pollution Control
Act of 1972, the Solid Waste Disposal Act, the Federal Resource Conservation and Recovery Act, the Toxic Substances Control Act
and the Emergency Planning and Community Right-to-Know Act.

 

“Equity
Securities” of any Person means (a) all common stock, preferred stock, participations, shares, partnership interests,
membership interests or other equity interests in and of such Person (regardless of how designated and whether or not voting or
non-voting) and (b) all warrants, options and other rights to acquire any of the foregoing.

 

“ERISA”
has the meaning given to such term in Section 7.12 of this Agreement.

 

“Event
of Default” has the meaning given to such term in Section 8 of this Agreement.

 

“Funding
Certificate” means a certificate executed by a duly authorized Responsible Officer of Borrower substantially in the
form of Exhibit B or such other form as Lender may agree to accept.

 

“Funding
Date” means any date on which a Loan is made to or on account of Borrower under this Agreement.

 

“GAAP”
means generally accepted accounting principles as in effect in the United States of America from time to time, consistently applied.

 

    	2

    	 

    

 

“Good
Faith Deposit” has the meaning given such term in Section 2.6(a) of this Agreement.

 

“Governmental
Authority” means (a) any federal, state, county, municipal or foreign government, or political subdivision thereof,
(b) any governmental or quasi-governmental agency, authority, board, bureau, commission, department, instrumentality or public
body, (c) any court or administrative tribunal, or (d) with respect to any Person, any arbitration tribunal or other non-governmental
authority to whose jurisdiction that Person has consented.

 

“Hazardous
Materials” means all those substances which are regulated by, or which may form the basis of liability under, any Environmental
Law, including all substances identified under any Environmental Law as a pollutant, contaminant, hazardous waste, hazardous constituent,
special waste, hazardous substance, hazardous material, or toxic substance, or petroleum or petroleum derived substance or waste.

 

“Horizon”
means Horizon Technology Finance Corporation.

 

“Indebtedness”
means, with respect to any Person, the aggregate amount of, without duplication, (a) all obligations of such Person for borrowed
money, (b) all obligations of such Person evidenced by bonds, debentures, notes or other similar instruments, (c) all obligations
of such Person to pay the deferred purchase price of property or services (excluding trade payables aged less than one hundred
eighty (180) days), (d) all capital lease obligations of such Person, (e) all obligations or liabilities of others secured by
a Lien on any asset of such Person, whether or not such obligation or liability is assumed, (f) all obligations or liabilities
of others guaranteed by such Person, and (g) any other obligations or liabilities which are required by GAAP to be shown as debt
on the balance sheet of such Person.

 

“Indemnified
Person” has the meaning given such term in Section 10.3 of this Agreement.

 

“Intellectual
Property” means, with respect to any Person, all of such Person’s right, title and interest in and to patents,
patent rights (and applications and registrations therefor and divisions, continuations, renewals, reissues, extensions and continuations-in-part
of the same), trademarks and service marks (and applications and registrations therefor and the goodwill associated therewith),
whether registered or not, inventions, copyrights (including applications and registrations therefor and like protections in each
work or authorship and derivative work thereof), whether published or unpublished, mask works (and applications and registrations
therefor), trade names, trade styles, software and computer programs, source code, object code, trade secrets, licenses, methods,
processes, know how, drawings, specifications, descriptions, and all memoranda, notes, and records with respect to any research
and development, all whether now owned or subsequently acquired or developed by such Person and whether in tangible or intangible
form or contained on magnetic media readable by machine together with all such magnetic media (but not including embedded computer
programs and supporting information included within the definition of “goods” under the Code).

 

“Internal
Revenue Code” has the meaning given such term in Section 5.19 of this Agreement.

 

“Investment”
means the purchase or acquisition of any capital stock, equity interest, or any obligations or other securities of, or any interest
in, any Person, or the extension of any advance, loan, extension of credit or capital contribution to, or any other investment
in, or deposit with, any Person.

 

    	3

    	 

    

 

“Landlord
Agreement” means an agreement substantially in the form provided by Lender to Borrower or such other form as Lender
may agree to accept.

 

“Lender”
means the Lender as set forth on the cover page of this Agreement.

 

“Lender’s
Expenses” means all reasonable costs or expenses (including reasonable attorneys’ fees and expenses) incurred
in connection with the preparation, negotiation, documentation, drafting, amendment, modification, administration, perfection
and funding of the Loan Documents; and all of Lender’s attorneys’ fees, costs and expenses incurred in enforcing or
defending the Loan Documents (including fees and expenses of appeal or review), including the exercise of any rights or remedies
afforded hereunder or under applicable law, whether or not suit is brought, whether before or after bankruptcy or insolvency,
including all fees and costs incurred by Lender in connection with such Lender’s enforcement of its rights in a bankruptcy
or insolvency proceeding filed by or against Borrower, any Subsidiary or their respective Property.

 

“Lien”
means any voluntary or involuntary security interest, pledge, bailment, lease, mortgage, hypothecation, conditional sales and
title retention agreement, encumbrance or other lien with respect to any Property in favor of any Person.

 

“Loan”
means each advance of credit by Lender to Borrower under this Agreement.

 

“Loan
A” means the advance of credit by Horizon to Borrower under this Agreement in the Loan A Commitment Amount.

 

“Loan
A Commitment Amount” has the meaning set forth on the cover page of this Agreement.

 

“Loan
A Commitment Termination Date” has the meaning set forth on the cover page of this Agreement.

 

“Loan
A Final Payment” has the meaning given such term in Section 2.2(g) of this Agreement.

 

“Loan
Amortization Date” means, with respect to each Loan, the Payment Date on which Borrower is required, pursuant to Section
2.2(a) below, to commence making equal payments of principal plus accrued interest on the outstanding principal amount of
such Loan.

 

“Loan
B” means the advance of credit by Horizon to Borrower under this Agreement in the Loan B Commitment Amount.

 

“Loan
B Commitment Amount” has the meaning set forth on the cover page of this Agreement.

 

“Loan
B Commitment Termination Date” has the meaning set forth on the cover page of this Agreement.

 

    	4

    	 

    

 

“Loan
B Final Payment” has the meaning given such term in Section 2.2(g) of this Agreement.

 

“Loan
C” means the advance of credit by Horizon to Borrower under this Agreement in the Loan C Commitment Amount.

 

“Loan
C Commitment Amount” has the meaning set forth on the cover page of this Agreement.

 

“Loan
C Commitment Termination Date” has the meaning set forth on the cover page of this Agreement.

 

“Loan
C Final Payment” has the meaning given such term in Section 2.2(g) of this Agreement.

 

“Loan
D” means the advance of credit by Horizon to Borrower under this Agreement in the Loan D Commitment Amount.

 

“Loan
D Commitment Amount” has the meaning set forth on the cover page of this Agreement.

 

“Loan
D Commitment Termination Date” has the meaning set forth on the cover page of this Agreement.

 

“Loan
D Final Payment” has the meaning given such term in Section 2.2(g) of this Agreement.

 

“Loan
Documents” means, collectively, this Agreement, the Notes, the Warrants, any Landlord Agreement, any Account Control
Agreement and all other documents, instruments and agreements entered into in connection with this Agreement.

 

“Loan
Rate” means, with respect to each Loan, the per annum rate of interest equal to 9.625% plus the amount by which
the one month LIBOR Rate (rounded to the nearest one hundredth percent), as reported in the Wall Street Journal exceeds
2.0%, provided, however that to the extent LIBOR (a) is no longer reported in the Wall Street Journal, (b) is no longer
widely used as a benchmark market rate for new facilities of this type, or (c) becomes permanently unavailable, Lender shall select
a successor benchmark rate, which successor rate shall be applied in a manner consistent with market practice, or if there is
no consistent market practice, such successor rate shall be applied in a manner reasonably determined by Lender. Notwithstanding
the foregoing, in no event shall the Loan Rate be less than 9.625%.

 

“Material
Adverse Effect” means a material adverse effect on (a) the condition (financial or otherwise), business, operations,
or Properties of Borrower, (b) the ability of Borrower to perform its Obligations under the Loan Documents or (c) the Collateral
or Collateral Agent’s or Lender’s security interest in the Collateral.

 

“Maturity
Date” means, with respect to each Loan, forty-eight (48) months from the first day of the month next following the month
in which the Funding Date for such Loan occurs, or if earlier, the date of acceleration of such Loan following an Event of Default
or the date of prepayment, whichever is applicable.

 

    	5

    	 

    

 

“Note”
means each promissory note executed in connection with a Loan in substantially the form of Exhibit C attached hereto.

 

“Obligations”
means all debt, principal, interest, fees, charges, expenses and attorneys’ fees and costs and other amounts, obligations,
covenants, and duties owing by Borrower to Collateral Agent or Lender of any kind and description (whether pursuant to or evidenced
by the Loan Documents (other than the Warrants), or by any other agreement between Lender and Borrower (other than the Warrants),
and whether or not for the payment of money), whether direct or indirect, absolute or contingent, due or to become due, now existing
or hereafter arising, including all Lender’s Expenses.

 

“OFAC”
means the Office of Foreign Assets Control of the United States Department of the Treasury.

 

“Officer’s
Certificate” means a certificate executed by a Responsible Officer substantially in the form of Exhibit E or
such other form as Lender may agree to accept.

 

“Payment
Date” has the meaning given such term in Section 2.2(a) of this Agreement.

 

“Permitted
Indebtedness” means and includes:

 

(a)
Indebtedness of Borrower to Lender under the Loan Documents;

 

(b)
Indebtedness arising from the endorsement of instruments in the ordinary course of business;

 

(c)
Indebtedness of Borrower existing on the date hereof and set forth on the Disclosure Schedule;

 

(d)
intercompany Indebtedness owed by any Subsidiary to Borrower or any wholly-owned Subsidiary, as applicable; provided that,
if applicable, such Indebtedness is also permitted as a Permitted Investment and, in the case of such Indebtedness owed to Borrower,
such Indebtedness shall be evidenced by one or more promissory notes; and

 

(e)
extensions, refinancings, modifications, amendments and restatements of any items of Permitted Indebtedness under subsection (c)
above; provided that the principal amount thereof is not increased or the terms thereof are not modified to impose materially
more burdensome terms upon Borrower.

 

“Permitted
Investments” means and includes any of the following Investments as to which Collateral Agent and Lender have a perfected
security interest:

 

(a)
Deposits and deposit accounts with commercial banks organized under the laws of the United States or a state thereof to the extent:
(i) the deposit accounts of each such institution are insured by the Federal Deposit Insurance Corporation up to the legal limit;
and (ii) each such institution has an aggregate capital and surplus of not less than One Hundred Million Dollars ($100,000,000);

 

    	6

    	 

    

 

(b)
Investments in marketable obligations issued or fully guaranteed by the United States and maturing not more than one (1) year
from the date of issuance;

 

(c)
Investments in corporate Notes and/or Bonds rated at least “A2/A” or higher by a national credit rating agency and
maturing not more than two (2) years from the creation thereof;

 

(d)
Investments in open market commercial paper rated at least “A1” or “P1” or higher by a national credit
rating agency and maturing not more than one (1) year from the creation thereof;

 

(e)
Investments pursuant to or arising under currency agreements or interest rate agreements entered into in the ordinary course of
business;

 

(f)
Investments by Borrower and Subsidiaries in their Subsidiaries outstanding on the date hereof; and

 

(g)
other Investments aggregating not in excess of One Hundred Thousand Dollars ($100,000) at any time.

 

“Permitted
Liens” means and includes:

 

(a)
the Liens created by this Agreement;

 

(b)
Liens for fees, taxes, levies, imposts, duties or other governmental charges of any kind which are not yet delinquent or which
are being contested in good faith by appropriate proceedings which suspend the collection thereof (provided that such appropriate
proceedings do not involve any substantial danger of the sale, forfeiture or loss of any material item of Collateral which in
the aggregate is material to Borrower and that Borrower has adequately bonded such Lien or reserves sufficient to discharge such
Lien have been provided on the books of Borrower);

 

(c)
Liens identified on the Disclosure Schedule;

 

(d)
carriers’, warehousemen’s, mechanics’, materialmen’s, repairmen’s or other similar Liens arising
in the ordinary course of business and which are not delinquent or remain payable without penalty or which are being contested
in good faith and by appropriate proceedings (provided that such appropriate proceedings do not involve any substantial
danger of the sale, forfeiture or loss of any material item of Collateral or Collateral which in the aggregate is material to
Borrower and that Borrower has adequately bonded such Lien or reserves sufficient to discharge such Lien have been provided on
the books of Borrower); and

 

(e)
non-exclusive licenses of Intellectual Property entered into in the ordinary course of business.

 

    	7

    	 

    

 

“Person”
means and includes any individual, any partnership, any corporation, any business trust, any joint stock company, any limited
liability company, any unincorporated association or any other entity and any domestic or foreign national, state or local government,
any political subdivision thereof, and any department, agency, authority or bureau of any of the foregoing.

 

“Property”
means any interest in any kind of property or asset, whether real, personal or mixed, whether tangible or intangible.

 

“Responsible
Officer” has the meaning given such term in Section 6.3 of this Agreement.

 

“Restricted
License” means any license or other agreement with respect to which Borrower is the licensee and such license or agreement
is material to Borrower’s business and (a) that prohibits or otherwise restricts Borrower from granting a security interest
in Borrower’s interest in such license or agreement or any other property or (b) for which a default under or termination
of could interfere with Collateral Agent’s or Lender’s right to sell any Collateral.

 

“Rights
to Payment” has the meaning given such term in Section 4.1 of this Agreement.

 

“Sanctions”
means any sanction administered or enforced by the United States Government (including, without limitation, OFAC and the United
States Department of State), the United Nations Security Council, the European Union, Her Majesty’s Treasury or other relevant
sanctions authority.

 

“Scheduled
Payments” has the meaning given such term in Section 2.2(a) of this Agreement.

 

“Solvent”
has the meaning given such term in Section 5.12 of this Agreement.

 

“Subsidiary”
means any corporation or other entity of which a majority of the outstanding Equity Securities entitled to vote for the election
of directors or other governing body (otherwise than as the result of a default) is owned by Borrower directly or indirectly through
Subsidiaries.

 

“Transfer”
has the meaning given such term in Section 7.4 of this Agreement.

 

“Warrant”
means the separate warrant or warrants dated on or about the date hereof in favor of each Lender or its designees to purchase
securities of Borrower.

 

1.2
Construction. References in this Agreement to “Articles,” “Sections,” “Exhibits,” “Schedules”
and “Annexes” are to recitals, articles, sections, exhibits, schedules and annexes herein and hereto unless otherwise
indicated. References in this Agreement and each of the other Loan Documents to any document, instrument or agreement shall include
(a) all exhibits, schedules, annexes and other attachments thereto, (b) all documents, instruments or agreements issued or executed
in replacement thereof, and (c) such document, instrument or agreement, or replacement or predecessor thereto, as amended, modified
and supplemented from time to time and in effect at any given time (subject, in the case of clauses (b) and (c), to any restrictions
on such replacement, amendment, modification or supplement set forth in the Loan Documents). The words “hereof,” “herein”
and “hereunder” and words of similar import when used in this Agreement or any other Loan Document shall refer to
this Agreement or such other Loan Document, as the case may be, as a whole and not to any particular provision of this Agreement
or such other Loan Document, as the case may be. The words “include” and “including” and words of similar
import when used in this Agreement or any other Loan Document shall not be construed to be limiting or exclusive. Unless the context
requires otherwise, any reference in this Agreement or any other Loan Document to any Person shall be construed to include such
Person’s successors and assigns. Unless otherwise indicated in this Agreement or any other Loan Document, all accounting
terms used in this Agreement or any other Loan Document shall be construed, and all accounting and financial computations hereunder
or thereunder shall be computed, in accordance with GAAP, and all terms describing Collateral shall be construed in accordance
with the Code. The terms and information set forth on the cover page of this Agreement are incorporated into this Agreement.

 

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2.
Loans; Repayment.

 

2.1
Commitments.

 

(a)
The Commitment Amounts. Subject to the terms and conditions of this Agreement and relying upon the representations and
warranties herein set forth as and when made or deemed to be made, Horizon agrees to lend to Borrower prior to the Loan A Commitment
Termination Date, Loan A, prior to the Loan B Commitment Termination Date, Loan B, prior to the Loan C Commitment Termination
Date, Loan C and prior to the Loan D Commitment Termination Date, Loan D.

 

(b)
The Loans and the Notes. The obligation of Borrower to repay the unpaid principal amount of and interest on each Loan shall
be evidenced by a Note issued to the Lender.

 

2.2
Use of Proceeds. The proceeds of each Loan shall be used solely for working capital or general corporate purposes of Borrower.Payments.

 

(a)
Scheduled Payments. Borrower shall make (i) a payment of accrued interest only to Lender on the outstanding principal amount
of each Loan on the first twenty-four (24) Payment Dates specified in the Note applicable to such Loan and (ii) an equal payment
of principal plus accrued interest to Lender on the outstanding principal amount of each Loan on the next twenty-four (24) Payment
Dates as set forth in the Note applicable to such Loan (collectively, the “Scheduled Payments”). Borrower shall
make such Scheduled Payments commencing on the date set forth in the Note applicable to such Loan and continuing thereafter on
the first Business Day of each calendar month (each a “Payment Date”) through the Maturity Date. In any event,
all unpaid principal and accrued interest shall be due and payable in full on the Maturity Date applicable to such Loan.

 

(b)
Interim Payment. Unless the Funding Date for a Loan is the first day of a calendar month, Borrower shall pay the per diem
interest (accruing at the Loan Rate from the Funding Date through the last day of that month) payable with respect to such Loan
on the first Business Day of the next calendar month.

 

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(c)
Payment of Interest. Borrower shall pay interest on each Loan at a per annum rate of interest equal to the Loan Rate. The
Loan Rate shall initially be calculated using the LIBOR Rate reported in the Wall Street Journal on the date which is five
(5) Business Days prior to the proposed date of disbursement of the Loan, but shall thereafter be calculated for each calendar
month using the LIBOR Rate reported in the Wall Street Journal on the first calendar day of such month, provided, however,
that if the first calendar day of any month is not a Business Day, the Loan Rate shall be calculated using the LIBOR Rate reported
in the Wall Street Journal on the Business Day immediately preceding the first calendar day of such month. Interest (including
interest at the Default Rate, if applicable) shall be computed on the basis of a 360-day year for the actual number of days elapsed.
Notwithstanding any other provision hereof, the amount of interest payable hereunder shall not in any event exceed the maximum
amount permitted by the law applicable to interest charged on commercial loans.

 

(d)
Application of Payments. All payments received by Lender prior to an Event of Default shall be applied as follows: (i)
first, to Lender’s Expenses then due and owing; and (ii) second, ratably, to all Scheduled Payments then due and owing (provided,
however, if such payments are not sufficient to pay the whole amount then due, such payments shall be applied first to unpaid
interest at the Loan Rate, then to the remaining amounts then due). After an Event of Default, all payments and application of
proceeds shall be made as set forth in Section 9.7.

 

(e)
Late Payment Fee. Borrower shall pay to Lender a late payment fee equal to six percent (6%) of any Scheduled Payment not
paid when due to such Lender.

 

(f)
Default Rate. Borrower shall pay interest at a per annum rate equal to the Default Rate on any amounts required to be paid
by Borrower to Collateral Agent or Lender under this Agreement or the other Loan Documents (including Scheduled Payments), payable
with respect to any Loan, accrued and unpaid interest, and any fees or other amounts which remain unpaid after such amounts are
due. If an Event of Default has occurred and the Obligations have been accelerated (whether automatically or by Lender’s
election), Borrower shall pay interest on the aggregate, outstanding accelerated balance hereunder from the date of the Event
of Default until all Events of Default are cured, at a per annum rate equal to the Default Rate.

 

(g)
Final Payment.

 

(i)
Loan A Final Payment. Borrower shall pay to Horizon a payment in the amount of One Hundred Thousand Dollars ($100,000)
(the “Loan A Final Payment”) upon the earlier of (A) payment in full of the principal balance of Loan A, (B)
an Event of Default and demand by Horizon of payment in full of Loan A or (C) the Maturity Date, as applicable.

 

(ii)
Loan B Final Payment. Borrower shall pay to Horizon a payment in the amount of One Hundred Thousand Dollars ($100,000)
(the “Loan B Final Payment”) upon the earlier of (A) payment in full of the principal balance of Loan B, (B)
an Event of Default and demand by Horizon of payment in full of Loan B or (C) the Maturity Date, as applicable.

 

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(iii)
Loan C Final Payment. Borrower shall pay to Horizon a payment in the amount of One Hundred Thousand Dollars ($100,000)
(the “Loan C Final Payment”) upon the earlier of (A) payment in full of the principal balance of Loan C, (B)
an Event of Default and demand by Horizon of payment in full of Loan C or (C) the Maturity Date, as applicable.

 

(iv)
Loan D Final Payment. Borrower shall pay to Horizon a payment in the amount of One Hundred Thousand Dollars ($100,000)
(the “Loan D Final Payment”) upon the earlier of (A) payment in full of the principal balance of Loan D, (B)
an Event of Default and demand by Horizon of payment in full of Loan D or (C) the Maturity Date, as applicable.

 

2.3
Prepayments.

 

(a)
Mandatory Prepayment Upon an Acceleration. If the Loans are accelerated following the occurrence of an Event of Default
pursuant to Section 9.1(a) hereof, then Borrower, in addition to any other amounts which may be due and owing hereunder, shall
immediately pay to Lender the amount set forth in Section 2.3(b) below, as if Borrower had opted to prepay on the date of such
acceleration.

 

(b)
Optional Prepayment. Upon ten (10) Business Days’ prior written notice to Lender, Borrower may, at its option, at
any time, prepay all (and not less than all) of the outstanding Loans by simultaneously paying to Lender an amount equal to (i)
any accrued and unpaid interest on the outstanding principal balance of the Loans; plus (ii) an amount equal to (A) if
such Loan is prepaid on or before the Loan Amortization Date applicable to such Loan, three percent (3%) of the then outstanding
principal balance of such Loan, (B) if such Loan is prepaid after the Loan Amortization Date applicable to such Loan, but on or
before the date that is twelve (12) months from such Loan Amortization Date, two percent (2%) of the then outstanding principal
balance of such Loan, or (C) if such Loan is prepaid more than twelve (12) months from the Loan Amortization Date applicable to
such Loan, one percent (1%) of the then outstanding principal balance of such Loan; plus (iii) the outstanding principal
balance of such Loan; plus (iv) all other sums, if any, that shall have become due and payable hereunder.

 

2.4
Other Payment Terms.

 

(a)
Place and Manner. Borrower shall make all payments due to Lender in lawful money of the United States. All payments of
principal, interest, fees and other amounts payable by Borrower hereunder shall be made, in immediately available funds, not later
than 10:00 a.m. Connecticut time, on the date on which such payment is due. Borrower shall make such payments to Lender via wire
transfer or ACH as instructed by Lender from time to time.

 

(b)
Date. Whenever any payment is due hereunder on a day other than a Business Day, such payment shall be made on the next
succeeding Business Day, and such extension of time shall be included in the computation of interest or fees, as the case may
be.

 

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(c)
Taxes.

 

(i)
Unless otherwise required under applicable law, any and all payments made hereunder or under the Notes shall be made free and
clear of and without deduction for any taxes; provided that if Borrower shall be required to deduct any taxes from such
payments, then (A) the sum payable shall be increased as necessary so that after making all required deductions (including deductions
applicable to additional sums payable under this Section 2.4(c)) the Lender receives an amount equal to the sum it would have
received had no such deductions been made, (B) Borrower shall make such deductions and (C) Borrower shall pay the full amount
deducted to the relevant Governmental Authority in accordance with applicable law.

 

(ii)
Borrower shall indemnify Lender, within 10 days after written demand therefor, for the full amount of any taxes imposed or asserted
directly on Lender by any Governmental Authority on or attributable to amounts payable under this Agreement solely as a result
of Lender entering into this Agreement to the extent such taxes are paid by Lender, and any penalties, interest and reasonable
expenses arising therefrom or with respect thereto, whether or not such taxes were correctly or legally imposed or asserted by
the relevant Governmental Authority; provided, however, that such indemnified taxes shall not include income or franchise
taxes imposed on (or measured by) Lender’s net income by the jurisdiction, or any political subdivision thereof or taxing
authority therein, under the laws of which such recipient is organized or in which its principal office is located or in which
its applicable lending office is located. A certificate as to the amount of such payment or liability delivered to Borrower by
Lender shall be conclusive absent manifest error.

 

(iii)
As soon as practicable after any payment of taxes by Borrower hereunder to a Governmental Authority, Borrower shall deliver to
Lender the original or a certified copy of a receipt issued by such Governmental Authority evidencing such payment, a copy of
the return reporting such payment or other evidence of such payment reasonably satisfactory to Lender.

 

(iv)
If Lender is entitled to an exemption from or reduction of withholding tax under the law of the jurisdiction in which Borrower
is located, or any treaty to which such jurisdiction is a party, with respect to payments under this Agreement, Lender shall deliver
to Borrower, as reasonably requested by Borrower, such properly completed and executed documentation prescribed by applicable
law as will permit such payments to be made without withholding or at a reduced rate.

 

(v)
If Lender receives a refund in respect of taxes paid by Borrower pursuant to this Section 2.4(c), which in the sole discretion
of Lender exercised in good faith is allocable to such payment, it shall promptly pay such refund, together with any other amounts
paid by Borrower in connection with such refunded taxes, to Borrower, net of all out-of-pocket expenses (including any taxes to
which Lender has become subject as a result of its receipt of such refund) of Lender incurred in obtaining such refund and without
interest (other than any interest paid by the relevant Governmental Authority with respect to such refund); provided that
Borrower, upon the request of the Lender, shall repay to Lender amounts paid over pursuant to the preceding clause (plus any penalties,
interest or other charges imposed by the relevant Governmental Authority) in the event that Lender is required to repay such refund
to such Governmental Authority. Notwithstanding anything to the contrary in this paragraph (v), in no event will Lender be required
to pay any amount to Borrower pursuant to this paragraph (v) the payment of which would place Lender in a less favorable net after-tax
position than Lender would have been in if the indemnification payments or additional amounts giving rise to such refund had never
been paid. This paragraph shall not be construed to require Lender to make available its tax returns (or any other information
relating to its taxes that it deems confidential) to Borrower or any other Person.

 

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2.5
Procedure for Making the Loans.

 

(a)
Notice. Borrower shall notify Lender of the date on which Borrower desires Lender to make any Loan at least five (5) Business
Days in advance of the desired Funding Date, unless the Lender elects at its sole discretion to allow the Funding Date for a Loan
to be made by Lender to be within five (5) Business Days of Borrower’s notice. Borrower’s execution and delivery to
Lender of one or more Notes in respect of a Loan shall be Borrower’s agreement to the terms and calculations thereunder
with respect to such Loan. Lender’s obligation to make any Loan shall be expressly subject to the satisfaction of the conditions
set forth in Section 3.

 

(b)
Loan Rate Calculation. Prior to each Funding Date for any Loan, Lender shall establish the Loan Rate with respect to such
Loan, which shall be set forth in the Note to be executed by Borrower with respect to such Loan and shall be conclusive in the
absence of a manifest error.

 

(c)
Disbursement. Lender shall disburse the proceeds of each Loan by wire transfer to Borrower at the account specified in
the Funding Certificate for such Loan.

 

2.6
Good Faith Deposit; Legal and Closing Expenses; and Commitment Fee.

 

(a)
Good Faith Deposit. Borrower has delivered to Horizon a good faith deposit in the amount of Fifty Thousand Dollars ($50,000)
(the “Good Faith Deposit”). The Good Faith Deposit paid to Horizon will be credited to the Commitment Fee payable
to the Lender. If the Funding Date does not occur, Lender shall retain the Good Faith Deposit as compensation for its time, expenses
and opportunity cost.

 

(b)
Legal, Due Diligence and Documentation Expenses. Concurrently with its execution and delivery of this Agreement, Borrower
shall pay to Lender all of Lender’s reasonable legal, due diligence and documentation expenses in connection with the negotiation
and documentation of this Agreement and the Loan Documents.

 

(c)
Commitment Fee. Borrower shall pay, concurrently with its execution and delivery of this Agreement, a commitment fee to
Horizon in the amount of One Hundred Thousand Dollars ($100,000) (the “Commitment Fee”). The Commitment Fee
shall be retained by the Lender and be deemed fully earned upon receipt.

 

3.
Conditions of Loan.

 

3.1
Conditions Precedent to Closing. At the time of the execution and delivery of this Agreement, Lender shall have received,
in form and substance reasonably satisfactory to Lender, all of the following (unless Lender has agreed to waive such condition
or document, in which case such condition or document shall be a condition precedent to the making of any Loan and shall be deemed
added to Section 3.2):

 

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(a)
Loan Agreement. This Agreement duly executed by Borrower, Collateral Agent and Lender.

 

(b)
Warrants. The Warrants duly executed by Borrower.

 

(c)
Secretary’s Certificate. A certificate of the secretary or assistant secretary of Borrower, dated as of the date
hereof, with copies of the following documents attached: (i) the certificate of incorporation and bylaws (or equivalent documents)
of Borrower certified by Borrower as being complete and in full force and effect on the date thereof, (ii) incumbency and representative
signatures, and (iii) resolutions authorizing the execution and delivery of this Agreement and each of the other Loan Documents.

 

(d)
Good Standing Certificates. A good standing certificate from Borrower’s state of organization and the state in which
Borrower’s principal place of business is located, each dated as of a date no earlier than thirty (30) days prior to the
date hereof.

 

(e)
Certificate of Insurance. Evidence of the insurance coverage required by Section 6.8 of this Agreement.

 

(f)
Consents. All necessary consents of shareholders and other third parties with respect to the execution, delivery and performance
of this Agreement, the Warrants and the other Loan Documents.

 

(g)
Legal Opinion. A legal opinion of Borrower’s counsel, dated as of the date hereof, covering the matters set forth
in Exhibit D hereto.

 

(h)
Account Control Agreements. Account Control Agreements for all of Borrower’s deposit accounts and securities accounts
duly executed by all of the parties thereto.

 

(i)
Fees and Expenses. Payment of all fees and expenses then due hereunder or under any other Loan Document.

 

(j)
Other Documents. Such other documents and completion of such other matters, as Lender may reasonably deem necessary or
appropriate.

 

3.2
Conditions Precedent to Making Loan A, Loan B, Loan C and Loan D. The obligation of Lender to make Loan A, Loan B, Loan
C or Loan D is further subject to satisfaction of the following conditions as of the applicable Funding Date:

 

(a)
No Default. No Default or Event of Default shall have occurred and be continuing.

 

(b)
Landlord Agreements. Borrower shall have provided Lender with a Landlord Agreement for each location where Borrower’s
books and records and the Collateral is located (unless Borrower is the fee owner thereof).

 

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(c)
Note. Borrower shall have duly executed and delivered a Note in the amount of each of Loan A, Loan B, Loan C and Loan D
to Horizon.

 

(d)
UCC Financing Statements. Lender shall have received such documents, instruments and agreements, including UCC financing
statements or amendments to UCC financing statements and UCC financing statement searches, as Lender shall reasonably request
to evidence the perfection and priority of the security interests granted to Collateral Agent and Lender pursuant to Section
4. Borrower authorizes Collateral Agent and Lender to file any UCC financing statements, continuations of or amendments to
UCC financing statements they deem necessary to perfect its security interest in the Collateral.

 

(e)
Funding Certificate. Borrower shall have duly executed and delivered to Lender a Funding Certificate for such Loans.

 

(f)
Representations and Warranties. The representations and warranties made by Borrower in Section 5 and in the other
Loan Documents shall be true and correct as of such Funding Date.

 

(g)
Other Documents. Borrower shall have provided Lender with such other documents and completion of such other matters, as
Lender may reasonably deem necessary or appropriate.

 

3.3
Covenant to Deliver. Borrower agrees (not as a condition but as a covenant) to deliver to Lender each item required to
be delivered to Lender as a condition to each Loan, if such Loan is advanced. Borrower expressly agrees that the extension of
any Loan prior to the receipt by Lender of any such item shall not constitute a waiver by Lender of Borrower’s obligation
to deliver such item, and any such extension in the absence of a required item shall be in Lender’s sole discretion.

 

4.
Creation of Security Interest.

 

4.1
Grant of Security Interests. Borrower grants to Collateral Agent and Lender a valid, continuing security interest in all
presently existing and hereafter acquired or arising Collateral in order to secure prompt, full and complete payment of any and
all Obligations and in order to secure prompt, full and complete performance by Borrower of each of its covenants and duties under
each of the Loan Documents (other than the Warrants). The “Collateral” shall mean and include all right, title, interest,
claims and demands of Borrower in the following:

 

(a)
All goods (and embedded computer programs and supporting information included within the definition of “goods” under
the Code) and equipment now owned or hereafter acquired, including all laboratory equipment, computer equipment, office equipment,
machinery, fixtures, vehicles (including motor vehicles and trailers), and any interest in any of the foregoing, and all attachments,
accessories, accessions, replacements, substitutions, additions, and improvements to any of the foregoing, wherever located;

 

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(b)
All inventory now owned or hereafter acquired, including all merchandise, raw materials, parts, supplies, packing and shipping
materials, work in process and finished products including such inventory as is temporarily out of Borrower’s custody or
possession or in transit and including any returns upon any accounts or other proceeds, including insurance proceeds, resulting
from the sale or disposition of any of the foregoing and any documents of title representing any of the above, and Borrower’s
books relating to any of the foregoing;

 

(c)
All contract rights and general intangibles (except to the extent included within the definition of Intellectual Property), now
owned or hereafter acquired, including goodwill, license agreements, franchise agreements, blueprints, drawings, purchase orders,
customer lists, route lists, infringements, claims, software, computer programs, computer disks, computer tapes, literature, reports,
catalogs, design rights, income tax refunds, payment intangibles, commercial tort claims, payments of insurance and rights to
payment of any kind;

 

(d)
All now existing and hereafter arising accounts, contract rights, royalties, license rights, license fees and all other forms
of obligations owing to Borrower arising out of the sale or lease of goods, the licensing of technology or the rendering of services
by Borrower (subject, in each case, to the contractual rights of third parties to require funds received by Borrower to be expended
in a particular manner), whether or not earned by performance, and any and all credit insurance, guaranties, and other security
therefor, as well as all merchandise returned to or reclaimed by Borrower and Borrower’s books relating to any of the foregoing;

 

(e)
All documents, cash, deposit accounts, letters of credit and letters of credit rights (whether or not the letter of credit is
evidenced by a writing) and other supporting obligations, certificates of deposit, instruments, promissory notes, chattel paper
(whether tangible or electronic) and investment property, including all securities, whether certificated or uncertificated, security
entitlements, securities accounts, commodity contracts and commodity accounts, and all financial assets held in any securities
account or otherwise, wherever located, now owned or hereafter acquired and Borrower’s books relating to the foregoing;
and

 

(f)
To the extent not covered by clauses (a) through (e), all other personal property of the Borrower, whether tangible or intangible,
and any and all rights and interests in any of the above and the foregoing and, any and all claims, rights and interests in any
of the above and all substitutions for, additions and accessions to and proceeds thereof, including insurance, condemnation, requisition
or similar payments and proceeds of the sale or licensing of Intellectual Property to the extent such proceeds no longer constitute
Intellectual Property; but

 

Notwithstanding
the foregoing, the Collateral shall not include any Intellectual Property; provided, however, that the Collateral
shall include all accounts receivables, accounts, and general intangibles that consist of rights to payment and proceeds from
the sale, licensing or disposition of all or any part, or rights in, the foregoing (the “Rights to Payment”).
Notwithstanding the foregoing, if a judicial authority (including a U.S. Bankruptcy Court) holds that a security interest in the
underlying Intellectual Property is necessary to have a security interest in the Rights to Payment, then the Collateral shall
automatically, and effective as of the date hereof, include the Intellectual Property to the extent necessary to permit perfection
of Lender’s security interest in the Rights to Payment.

 

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Notwithstanding
the foregoing, if (i) Borrower’s Phase III clinical trial entitled “Study of ThermoDox With Standardized Radiofrequency
Ablation (RFA) for Treatment of Hepatocellular Carcinoma (HCC) (OPTIMA)” does not meet the final primary endpoints for such
trial (which endpoints are set forth on the United States National Library of Medicine clinical trial tracking website located
at www.clinicaltrials.gov, under Identifier NCT02112656) or (ii) the United States Food and Drug Administration states
that such clinical trial shall be discontinued, then, (A) Borrower grants and pledges to Collateral Agent and Lenders a continuing
security interest in all of Borrower’s then owned and thereafter arising Intellectual Property in order to secure prompt
payment of any and all Obligations and in order to secure prompt performance by Borrower of each of its covenants and duties under
the Loan Documents, (B) the definition of “Collateral” shall be amended, automatically and immediately, without any
further action or writing required by the parties such that all of Borrower’s Intellectual Property then owned and thereafter
arising or acquired becomes part of the Collateral for all purposes of the Loan Agreement, (C) Collateral Agent and Lenders shall
be authorized to file an amendment to their UCC-1 financing statements to reflect the inclusion of the Intellectual Property within
the description of the Collateral as well as appropriate documentation with the United Stated Patent and Trademark Office to evidence
such security interest and (D) Borrower shall execute and deliver, at Borrower’s sole cost and expense, all documents and
instruments reasonably necessary to perfect such security interest, including, but not limited to, intellectual property security
agreements.

 

4.2
After-Acquired Property. If Borrower shall at any time acquire a commercial tort claim, as defined in the Code, Borrower
shall immediately notify Collateral Agent and Lender in writing signed by Borrower of the brief details thereof and grant to Collateral
Agent and Lender in such writing a security interest therein and in the proceeds thereof, all upon the terms of this Agreement,
with such writing to be in form and substance satisfactory to Collateral Agent and Lender.

 

4.3
Duration of Security Interest. Collateral Agent’s and Lender’s security interest in the Collateral shall continue
until the indefeasible payment in full and the satisfaction of all Obligations, and termination of Lender’s commitment to
fund the Loans, whereupon such security interest shall terminate. Collateral Agent and Lender shall, at Borrower’s sole
cost and expense, execute such further documents and take such further actions as may be reasonably necessary to make effective
the release contemplated by this Section 4.3, including duly authorizing and delivering termination statements for filing in all
relevant jurisdictions under the Code.

 

4.4
Location and Possession of Collateral. The Collateral is and shall remain in the possession of Borrower at its location
listed on the cover page hereof or as set forth in the Disclosure Schedule. Borrower shall remain in full possession, enjoyment
and control of the Collateral (except only as may be otherwise required by Collateral Agent or Lender for perfection of the security
interests therein created hereunder) and so long as no Event of Default has occurred, shall be entitled to manage, operate and
use the same and each part thereof with the rights and franchises appertaining thereto; provided that the possession, enjoyment,
control and use of the Collateral shall at all times be subject to the observance and performance of the terms of this Agreement.

 

4.5
Delivery of Additional Documentation Required. Borrower shall from time to time execute and deliver to Collateral Agent
and Lender, at the request of Collateral Agent or Lender, all financing statements and other documents Collateral Agent or Lender
may reasonably request, in form satisfactory to Collateral Agent and Lender, to perfect and continue Collateral Agent’s
and Lender’s perfected security interests in the Collateral and in order to consummate fully all of the transactions contemplated
under the Loan Documents.

 

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4.6
Right to Inspect. Collateral Agent and Lender (through any of their officers, employees, or agents) shall have the right,
upon reasonable prior notice, from time to time during Borrower’s usual business hours, to inspect the books and records
of Borrower and Subsidiaries and to make copies thereof and to inspect, test, and appraise the Collateral in order to verify Borrower’s
financial condition or the amount, condition of, or any other matter relating to, the Collateral. Any inspection, test or appraisal
conducted hereunder shall be conducted at the sole cost and expense of Borrower.

 

4.7
Intellectual Property.

 

(a)
At Lender’s request, Borrower shall register or cause to be registered with the United States Copyright Office (i) any software
(material to the business of Borrower) developed or acquired by Borrower in connection with any product developed or acquired
for sale or licensing, (ii) any software (material to the business of Borrower) developed or acquired by Borrower hereafter from
time to time in connection with any product developed or acquired for sale or licensing, and (iii) any major revisions or upgrades
to any software that has previously been registered by or on behalf of Borrower with the United States Copyright Office.

 

(b)
Borrower shall promptly notify Lender on or before the federal registration or filing by Borrower of any patent or patent application,
or trademark or trademark application, or copyright or copyright application and shall promptly execute and deliver to Lender
any grants of security interests in same, in form acceptable to Lender, to file with the United States Patent and Trademark Office
or the United States Copyright Office, as applicable.

 

4.8
Protection of Intellectual Property. Borrower shall:

 

(a)
protect, defend and maintain the validity and enforceability of its Intellectual Property and promptly advise Collateral Agent
in writing of material infringements;

 

(b)
not allow any Intellectual Property material to Borrower’s business to be abandoned, forfeited or dedicated to the public
without Lender’s written consent;

 

(c)
provide written notice to Collateral Agent within ten (10) days of entering or becoming bound by any Restricted License (other
than over-the-counter software that is commercially available to the public); and

 

(d)
take such commercially reasonable steps as Collateral Agent or Lender requests to obtain the consent of, or waiver by, any person
whose consent or waiver is necessary for (i) any Restricted License to be deemed “Collateral” and for Collateral Agent
and Lender to have a security interest in it that might otherwise be restricted or prohibited by law or by the terms of any such
Restricted License, whether now existing or entered into in the future, and (ii) Collateral Agent and Lender to have the ability
in the event of a liquidation of any Collateral to dispose of such Collateral in accordance with Collateral Agent’s or Lender’s
rights and remedies under this Agreement and the other Loan Documents.

 

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5.
Representations and Warranties. Except as set forth in the Disclosure Schedule, Borrower represents and warrants as follows:

 

5.1
Organization and Qualification. Each of Borrower and its Subsidiaries is a corporation duly organized and validly existing
under the laws of its state of incorporation and qualified and licensed to do business in, and is in good standing in, any jurisdiction
in which the conduct of its business or its ownership of Property requires that it be so qualified and licensed or in which the
Collateral is located, except for such states as to which any failure to so qualify would not have a Material Adverse Effect.

 

5.2
Authority. Borrower has all necessary power and authority to execute, deliver, and perform in accordance with the terms
thereof, the Loan Documents to which it is a party. Borrower and Subsidiaries have all requisite power and authority to own and
operate their Property and to carry on their businesses as now conducted. Borrower and Subsidiaries have obtained all licenses,
permits, approvals and other authorizations necessary for the operation of their business.

 

5.3
Conflict with Other Instruments, etc. Neither the execution and delivery of any Loan Document to which Borrower is a party
nor the consummation of the transactions therein contemplated nor compliance with the terms, conditions and provisions thereof
will conflict with or result in a breach of any of the terms, conditions or provisions of the certificate of incorporation, the
by-laws, or any other organizational documents of Borrower or any law or any regulation, order, writ, injunction or decree of
any court or Governmental Authority by which Borrower or any Subsidiary or any of their respective property or assets may be bound
or affected or any material agreement or instrument to which Borrower is a party or by which it or any of its Property is bound
or to which it or any of its Property is subject, or constitute a default thereunder or result in the creation or imposition of
any Lien, other than Permitted Liens.

 

5.4
Authorization; Enforceability. The execution and delivery of this Agreement, the granting of the security interest in the
Collateral, the incurrence of the Loans, the execution and delivery of the other Loan Documents to which Borrower is a party and
the consummation of the transactions herein and therein contemplated have each been duly authorized by all necessary action on
the part of Borrower. No authorization, consent, approval, license or exemption of, and no registration, qualification, designation,
declaration or filing with, or notice to, any Person is, was or will be necessary to (a) the valid execution and delivery of any
Loan Document to which Borrower is a party, (b) the performance of Borrower’s obligations under any Loan Document or (c)
the granting of the security interest in the Collateral, except for filings in connection with the perfection of the security
interest in any of the Collateral or the issuance of the Warrants. The Loan Documents have been duly executed and delivered and
constitute legal, valid and binding obligations of Borrower, enforceable in accordance with their respective terms, except as
the enforceability thereof may be limited by bankruptcy, insolvency or other similar laws of general application relating to or
affecting the enforcement of creditors’ rights or by general principles of equity.

 

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5.5
No Prior Encumbrances. Borrower has good and marketable title to the Collateral, free and clear of Liens except for Permitted
Liens. Borrower has good title and ownership of, or is licensed under, all of Borrower’s current Intellectual Property.
Borrower is the sole owner of the Intellectual Property which it owns or purports to own except for (a) non-exclusive licenses
granted to its customers, resellers and/or distributors in the ordinary course of business, (b) over-the-counter software that
is commercially available to the public and (c) material Intellectual Property licensed to Borrower and noted on the Disclosure
Schedule. Each patent which it owns or purports to own and which is material to Borrower’s business is valid and enforceable,
and no part of the Intellectual Property which Borrower owns or purports to own and which is material to Borrower’s business
has been judged invalid or unenforceable, in whole or in part. Except as noted on the Disclosure Schedule, Borrower is not a party
to, nor is it bound by, any Restricted License. Borrower has not received any communications alleging that Borrower has violated,
or by conducting its business as proposed, would violate any proprietary rights of any other Person. Borrower has no knowledge
of any infringement or violation by it of the intellectual property rights of any third party and has no knowledge of any violation
or infringement by a third party of any of its Intellectual Property. The Collateral and the Intellectual Property constitute
substantially all of the assets and property of Borrower, and Borrower owns all Intellectual Property associated with the business
of Borrower and Subsidiaries, free and clear of any liens other than Permitted Liens.

 

5.6
Security Interest. The provisions of this Agreement create legal and valid security interests in the Collateral in favor
of Collateral Agent and Lender, and, assuming the proper filing of one or more financing statement(s) identifying the Collateral
with the proper state and/or local authorities and the taking of any other actions necessary to perfect a security interest in
the Collateral under the Code, the security interests in the Collateral granted to Collateral Agent and Lender pursuant to this
Agreement (a) constitute and will continue to constitute first priority security interests (except to the extent any Permitted
Liens may have a superior priority to Collateral Agent’s and Lender’s Liens under this Agreement) and (b) are and
will continue to be superior and prior to the rights of all other creditors of Borrower (except to the extent any Permitted Liens
may have a superior priority to Collateral Agent’s and Lender’s Liens under this Agreement).

 

5.7
Name; Location of Chief Executive Office, Principal Place of Business and Collateral. Borrower has not done business under
any name other than that specified on the signature page hereof. Borrower’s jurisdiction of incorporation, chief executive
office, principal place of business, and the place where Borrower maintains its records concerning the Collateral are presently
located in the state and at the address set forth on the cover page of this Agreement. The Collateral is presently located at
the address set forth on the cover page hereof or as set forth in the Disclosure Schedule.

 

5.8
Litigation. There are no actions or proceedings pending by or against Borrower or any Subsidiary before any court, arbitral
tribunal, regulatory organization, administrative agency or similar body in which an adverse decision could have a Material Adverse
Effect. Borrower does not have knowledge of any such pending or threatened actions or proceedings.

 

5.9
Financial Statements. All financial statements relating to Borrower, any Subsidiary or any Affiliate that have been or
may hereafter be delivered by Borrower to Collateral Agent or Lender present fairly in all material respects Borrower’s
Consolidated financial condition as of the date thereof and Borrower’s Consolidated results of operations for the period
then ended.

 

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5.10
No Material Adverse Effect. No event has occurred and no condition exists which could reasonably be expected to have a
Material Adverse Effect since December 31, 2017.

 

5.11
Full Disclosure. No representation, warranty or other statement made by Borrower in any Loan Document (including the Disclosure
Schedule), certificate or written statement furnished to Collateral Agent or Lender contains any untrue statement of a material
fact or omits to state a material fact necessary in order to make the statements contained in such certificates or statements
not misleading. There is no fact known to Borrower which materially adversely affects, or which could in the future be reasonably
expected to materially adversely affect, its ability to perform its obligations under this Agreement.

 

5.12
Solvency, Etc. Borrower is Solvent (as defined below) and, after the execution and delivery of the Loan Documents
and the consummation of the transactions contemplated thereby, Borrower will be Solvent. “Solvent” means, with respect
to any Person on any date, that on such date (a) the fair value of the property of such Person is greater than the fair value
of the liabilities (including contingent liabilities) of such Person, (b) the present fair saleable value of the assets of such
Person is not less than the amount that will be required to pay the probable liability of such Person on its debts as they become
absolute and matured, (c) such Person does not intend to, and does not believe that it will, incur debts or liabilities beyond
such Person’s ability to pay as such debts and liabilities mature and (d) such Person is not engaged in business or a transaction,
and is not about to engage in business or a transaction, for which such Person’s property would constitute an unreasonably
small capital.

 

5.13
Subsidiaries. Borrower has no Subsidiaries.

 

5.14
Capitalization. All issued and outstanding Equity Securities of Borrower are duly authorized and validly issued, fully
paid and non-assessable, and such securities were issued in compliance with all applicable state and federal laws concerning the
issuance of securities, except for such compliance with such laws that would not reasonably be expected to result in a Material
Adverse Effect.

 

5.15
Catastrophic Events; Labor Disputes. None of Borrower, any Subsidiary or any of their respective Property is or
has been affected by any fire, explosion, accident, strike, lockout or other labor dispute, drought, storm, hail, earthquake,
embargo, act of God or other casualty that could reasonably be expected to have a Material Adverse Effect. There are no disputes
presently subject to grievance procedure, arbitration or litigation under any of the collective bargaining agreements, employment
contracts or employee welfare or incentive plans to which Borrower or any Subsidiary is a party, and there are no strikes, lockouts,
work stoppages or slowdowns, or, to the knowledge of Borrower, jurisdictional disputes or organizing activity occurring or threatened
which could reasonably be expected to have a Material Adverse Effect.

 

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5.16
Certain Agreements of Officers, Employees and Consultants.

 

(a)
No Violation. To the knowledge of Borrower, no officer, employee or consultant of Borrower is, or is now expected to be,
in violation of any term of any employment contract, proprietary information agreement, nondisclosure agreement, noncompetition
agreement or any other material contract or agreement or any restrictive covenant relating to the right of any such officer, employee
or consultant to be employed by Borrower because of the nature of the business conducted or to be conducted by Borrower or relating
to the use of trade secrets or proprietary information of others, and to Borrower’s knowledge, the continued employment
of Borrower’s officers, employees and consultants does not subject Borrower to any material liability for any claim or claims
arising out of or in connection with any such contract, agreement, or covenant.

 

(b)
No Present Intention to Terminate. To the knowledge of Borrower, no officer of Borrower, and no employee or consultant
of Borrower whose termination, either individually or in the aggregate, could reasonably be expected to have a Material Adverse
Effect, has any present intention of terminating his or her employment or consulting relationship with Borrower.

 

5.17
No Plan Assets. Neither Borrower nor any Subsidiary is an “employee benefit plan,” as defined in Section 3(3)
of ERISA, subject to Title I of ERISA, and none of the assets of Borrower or any Subsidiary constitutes or will constitute “plan
assets” of one or more such plans within the meaning of 29 C.F.R. Section 2510.3-101. In addition, (a) neither Borrower
nor any Subsidiary is a “governmental plan” within the meaning of Section 3(32) of ERISA and (b) transactions by or
with Borrower or any Subsidiary are not subject to state statutes regulating investment of, and fiduciary obligations with respect
to, governmental plans similar to the provisions of Section 406 of ERISA or Section 4975 of the Internal Revenue Code currently
in effect, which prohibit or otherwise restrict the transactions contemplated by this Loan Agreement.

 

5.18
Sanctions, Etc. None of Borrower, any of its Subsidiaries or, any director, officer, employee, agent or Affiliate of Borrower
or any of its Subsidiaries, is a Person that is, or is owned or controlled by Persons that are, (a) the subject or target of any
Sanctions or (b) located, organized or resident in a country or territory that is, or whose government is, the subject of Sanctions.
To the best of Borrower’s knowledge, as of the date hereof and at all times throughout the term of this Agreement, including
after giving effect to any transfers of interests permitted pursuant to the Loan Documents, none of the funds of Borrower, any
Subsidiary or of their Affiliates have been (or will be) derived from any unlawful activity with the result that the investment
in the respective party (whether directly or indirectly), is prohibited by applicable law or the Loans are in violation of applicable
law.

 

5.19
Regulatory Compliance. Borrower is not a “bank holding company” or a direct or indirect subsidiary of a “bank
holding company” as defined in the Bank Holding Company Act of 1956, as amended, and Regulation Y thereunder of the Board
of Governors of the Federal Reserve System. Neither Borrower nor any Subsidiary is an “investment company” or a company
controlled by an “investment company” under the Investment Company Act of 1940. Borrower is not engaged in the business
of extending credit for the purpose of purchasing or carrying margin stock (as defined in Regulation U of the Board of Governors
of the Federal Reserve System) and no proceeds of any Loan will be used to purchase or carry margin stock or to extend credit
to others for the purpose of purchasing or carrying any margin stock.

 

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5.20
Payment of Taxes. All federal and other material tax returns, reports and statements (including any attachments thereto
or amendments thereof) of Borrower and its Subsidiaries filed or required to be filed by any of them have been timely filed (or
extensions have been obtained and such extensions have not expired) and all taxes shown on such tax returns or otherwise due and
payable and all assessments, fees and other governmental charges upon Borrower, its Subsidiaries and their respective properties,
assets, income, businesses and franchises which are due and payable have been paid when due and payable, except for the payment
of any such taxes, assessments, fees and other governmental charges which are being diligently contested by Borrower in good faith
by appropriate proceedings and for which adequate reserves have been made under GAAP. To the knowledge of Borrower, no tax return
of Borrower or any Subsidiary is currently under an audit or examination, and Borrower has not received written notice of any
proposed audit or examination, in each case, where a material amount of tax is at issue. Borrower is not an “S corporation”
within the meaning of Section 1361(a)(1) of the Internal Revenue Code of 1986, as amended (the “Internal Revenue Code”).

 

5.21
Anti-Terrorism Laws. Borrower will not, directly or indirectly, use the proceeds of the Loans, or lend, contribute or otherwise
make available such proceeds to any Subsidiary, joint venture partner or other Person, (i) to fund any activities or business
of or with any Person, or in any country or territory, that, at the time of such funding, is, or whose government is, the subject
of Sanctions, or (ii) in any other manner that would result in a violation of Sanctions by any Person (including any Person participating
in the Loans, whether as lender, underwriter, advisor, investor or otherwise). Lender hereby notifies Borrower that pursuant to
the requirements of Anti-Terrorism Laws, and Lender’s policies and practices, Lender is required to obtain, verify and record
certain information and documentation that identifies Borrower and its principals, which information includes the name and address
of Borrower and its principals and such other information that will allow Lender to identify such party in accordance with Anti-Terrorism
Laws.

 

6.
Affirmative Covenants. Borrower, until the full and complete payment of the Obligations, covenants and agrees that:

 

6.1
Good Standing. Borrower shall maintain, and cause each of its Subsidiaries to maintain, its corporate existence and its
good standing in its jurisdiction of incorporation and maintain qualification in each jurisdiction in which the failure to so
qualify could reasonably be expected to have a Material Adverse Effect. Borrower shall maintain, and cause each of its Subsidiaries
to maintain, in force all licenses, approvals and agreements, the loss of which could reasonably be expected to have a Material
Adverse Effect.

 

6.2
Government Compliance. Borrower shall comply, and cause each of its Subsidiaries to comply, with all statutes, laws, ordinances
and government rules and regulations to which it is subject, noncompliance with which could reasonably be expected to have a Material
Adverse Effect.

 

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6.3
Financial Statements, Reports, Certificates. Borrower shall deliver to Lender: (a) as soon as available, but in any event
within forty-five (45) days after the end of each fiscal quarter, a Borrower prepared Consolidated balance sheet, Consolidated
income statement and Consolidated cash flow statement covering Borrower’s operations during such period, certified by Borrower’s
president, treasurer or chief financial officer (each, a “Responsible Officer”); (b) as soon as available, but in
any event within one hundred eighty (180) days after the end of Borrower’s fiscal year, audited Consolidated financial statements
of Borrower prepared in accordance with GAAP, together with an unqualified opinion on such financial statements of a nationally
recognized or other independent public accounting firm reasonably acceptable to Lender; and (c) as soon as available, but in any
event within thirty (30) days after the earlier of (i) the end of Borrower’s fiscal year or (ii) the date of Borrower’s
board of directors’ adoption, Borrower’s operating budget and plan for the next fiscal year; and (d) such other financial
information as Lender may reasonably request from time to time. From and after such time as Borrower becomes a publicly reporting
company, promptly as they are available and in any event: (i) at the time of filing of Borrower’s Form 10-K with the Securities
and Exchange Commission after the end of each fiscal year of Borrower, the financial statements of Borrower filed with such Form
10-K; and (ii) at the time of filing of Borrower’s Form 10-Q with the Securities and Exchange Commission after the end of
each of the first three fiscal quarters of Borrower, the Consolidated financial statements of Borrower filed with such Form 10-Q.
In addition, Borrower shall deliver to Lender (A) promptly upon becoming available, copies of all statements, reports and notices
sent or made available generally by Borrower to its security holders and (B) immediately upon receipt of notice thereof, a report
of any material legal actions pending or threatened against Borrower or any Subsidiary or the commencement of any action, proceeding
or governmental investigation involving Borrower or any Subsidiary is commenced that is reasonably expected to result in damages
or costs to Borrower of Fifty Thousand Dollars ($50,000) or more.

 

6.4
Certificates of Compliance. Each time financial statements are furnished pursuant to Section 6.3 above, Borrower shall
deliver to Lender an Officer’s Certificate signed by a Responsible Officer in the form of, and certifying to the matters
set forth in Exhibit E hereto.

 

6.5
Notice of Defaults. As soon as possible, and in any event within five (5) days after the discovery of a Default or an Event
of Default, Borrower shall provide Lender with an Officer’s Certificate setting forth the facts relating to or giving rise
to such Default or Event of Default and the action which Borrower proposes to take with respect thereto.

 

6.6
Taxes. Borrower shall make, and cause each Subsidiary to make, due and timely payment or deposit of all federal, state,
and local taxes, assessments, or contributions required of it by law or imposed upon any Property belonging to it, and will execute
and deliver to Collateral Agent and Lender, on demand, appropriate certificates attesting to the payment or deposit thereof; and
Borrower will make, and cause each Subsidiary to make, timely payment or deposit of all tax payments and withholding taxes required
of it by applicable laws, including those laws concerning F.I.C.A., F.U.T.A., state disability, and local, state, and federal
income taxes, and will, upon request, furnish Collateral Agent and Lender with proof satisfactory to Lender indicating that Borrower
and each Subsidiary has made such payments or deposits; provided that Borrower need not make any payment if the amount
or validity of such payment is contested in good faith by appropriate proceedings which suspend the collection thereof (provided
that such proceedings do not involve any substantial danger of the sale, forfeiture or loss of any material item of Collateral
or Collateral which in the aggregate is material to Borrower and that Borrower has adequately bonded such amounts or reserves
sufficient to discharge such amounts have been provided on the books of Borrower). In addition, Borrower shall not change, and
shall not permit any Subsidiary to change, its respective jurisdiction of residence for taxation purposes.

 

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6.7
Use; Maintenance. Borrower shall keep and maintain all items of equipment and other similar types of personal property
that form any significant portion or portions of the Collateral in good operating condition and repair and shall make all necessary
replacements thereof and renewals thereto so that the value and operating efficiency thereof shall at all times be maintained
and preserved. Borrower shall not permit any such material item of Collateral to become a fixture to real estate or an accession
to other personal property, without the prior written consent of Collateral Agent and Lender. Borrower shall not permit any such
material item of Collateral to be operated or maintained in violation of any applicable law, statute, rule or regulation. With
respect to items of leased equipment (to the extent Collateral Agent and Lender have any security interest in any residual Borrower’s
interest in such equipment under the lease), Borrower shall keep, maintain, repair, replace and operate such leased equipment
in accordance with the terms of the applicable lease.

 

6.8
Insurance. Borrower shall keep its business and the Collateral insured for risks and in amounts standard for companies
in Borrower’s industry and location, and as Collateral Agent or Lender may reasonably request. Insurance policies shall
be in a form, with companies, and in amounts that are reasonably satisfactory to Collateral Agent and Lender. All property policies
shall have a lender’s loss payable endorsement showing Collateral Agent and Lender as an additional loss payee and all liability
policies shall show Collateral Agent and Lender as an additional insured and all policies shall provide that the insurer must
give Collateral Agent at least thirty (30) days notice before canceling its policy. At Collateral Agent’s or Lender’s
request, Borrower shall deliver certified copies of policies and evidence of all premium payments. Proceeds payable under any
property policy shall, at Collateral Agent’s or Lender’s option, be payable to Collateral Agent, for the benefit of
Lender, or to Lender on account of the Obligations. Notwithstanding the foregoing, so long as no Event of Default has occurred
and is continuing, Borrower shall have the option of applying the proceeds of any property policy, toward the replacement or repair
of destroyed or damaged property; provided that (a) any such replaced or repaired property (i) shall be of equal or like
value as the replaced or repaired Collateral and (ii) shall be deemed Collateral in which Collateral Agent and Lender have been
granted a first priority security interest and (b) after the occurrence and during the continuation of an Event of Default all
proceeds payable under such property policy shall, at the option of Collateral Agent or Lender, be payable to Collateral Agent,
for the benefit of Lender, or to Lender on account of the Obligations. If Borrower fails to obtain insurance as required under
Section 6.8 or to pay any amount or furnish any required proof of payment to third persons and Collateral Agent, Collateral Agent
or Lender may make all or part of such payment or obtain such insurance policies required in Section 6.8, and take any action
under the policies Collateral Agent or Lender deems prudent. On or prior to the first Funding Date and prior to each policy renewal,
Borrower shall furnish to Collateral Agent certificates of insurance or other evidence satisfactory to Collateral Agent that insurance
complying with all of the above requirements is in effect.

 

6.9
Further Assurances. At any time and from time to time Borrower shall execute and deliver such further instruments and take
such further action as may reasonably be requested by Collateral Agent or Lender to make effective the purposes of this Agreement,
including the continued perfection and priority of Collateral Agent’s Lender’s security interest in the Collateral.

 

6.10
Subsidiaries. Borrower, upon Lender’s or Collateral Agent’s request, shall cause any Subsidiary to provide
Lender and Collateral Agent with a guaranty of the Obligations and a security interest in such Subsidiary’s assets to secure
such guaranty.

 

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6.11
Keeping of Books. Borrower shall keep proper books of record and account, in which full and correct entries shall be made
of all financial transactions and the assets and business of Borrower and its Subsidiaries in accordance with GAAP.

 

6.12
Liquidity Covenant. Borrower shall, at all times until the indefeasible repayment in full of the Obligations, maintain
not less than Five Million Dollars ($5,000,000) on deposit in accounts over which Lender maintains an Account Control Agreement.

 

7.
Negative Covenants. Borrower, until the full and complete payment of the Obligations, covenants and agrees that Borrower
shall not:

 

7.1
Chief Executive Office. Change its name, jurisdiction of incorporation, chief executive office, principal place of business
or any of the items set forth in Section 1 of the Disclosure Schedule without thirty (30) days prior written notice to Collateral
Agent.

 

7.2
Collateral Control. Subject to its rights under Sections 4.4 and 7.4, remove any items of Collateral from Borrower’s
facility located at the address set forth on the cover page hereof or as set forth on the Disclosure Schedule.

 

7.3
Liens. Create, incur, allow or suffer, or permit any Subsidiary to create, incur, allow or suffer, any Lien on any of its
property, or assign or convey any right to receive income, including the sale of any accounts except for Permitted Liens, or permit
any Collateral not to be subject to the first priority security interest granted herein (except for Permitted Liens that are permitted
by the terms of this Agreement to have priority to Collateral Agent’s and Lender’s Liens), or enter into any agreement,
document, instrument or other arrangement (except with or in favor of Collateral Agent, for the benefit of Lender, or Lender)
with any Person which directly or indirectly prohibits or has the effect of prohibiting Borrower or any Subsidiary from assigning,
mortgaging, pledging, granting a security interest in or upon, or encumbering any of Borrower’s or any Subsidiary’s
Intellectual Property, except (a) as otherwise permitted in Section 7.4 hereof and (b) as permitted in the definition of “Permitted
Liens” herein.

 

7.4
Other Dispositions of Collateral. Convey, sell, lease or otherwise dispose of, or permit any Subsidiary to convey, sell,
lease or otherwise dispose, of all or any part of the Collateral to any Person (collectively, a “Transfer”), except
for: (a) Transfers of inventory in the ordinary course of business; (b) Transfers of worn-out or obsolete equipment made in the
ordinary course of business; and (c) Transfers permitted under subclause (g) of the definition of Permitted Liens with respect
to Collateral.

 

7.5
Distributions. (a) Pay any dividends or make any distributions, or permit any Subsidiary to pay any dividends or make any
distributions, on their respective Equity Securities; (b) purchase, redeem, retire, defease or otherwise acquire, or permit any
Subsidiary to purchase, redeem, retire, defease or otherwise acquire, for value any of their respective Equity Securities (other
than repurchases pursuant to the terms of employee stock purchase plans, employee restricted stock agreements or similar arrangements
in an aggregate amount not to exceed One Hundred Thousand Dollars ($100,000) in any fiscal year); (c) return, or permit any Subsidiary
to return, any capital to any holder of its Equity Securities as such; (d) make, or permit any Subsidiary to make, any distribution
of assets, Equity Securities, obligations or securities to any holder of its Equity Securities as such; or (e) set apart any sum
for any such purpose; provided, however, Borrower may pay dividends payable solely in Borrower’s common stock.

 

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7.6
Mergers or Acquisitions. Merge or consolidate, or permit any Subsidiary to merge or consolidate, with or into any other
Person or acquire, or permit any Subsidiary to acquire, all or substantially all of the capital stock or assets of another Person;
provided that (a) any Subsidiary may merge into another Subsidiary and (b) any Subsidiary may merge into Borrower so long
as Borrower is the surviving entity.

 

7.7
Change in Business or Ownership. Engage, or permit any Subsidiary to engage, in any business other than the businesses
currently engaged in by Borrower or such Subsidiary, as applicable, or reasonably related thereto or have a material change in
Borrower’s ownership equal to or greater than twenty-five percent (25%) other than (a) by the sale by Borrower of Borrower’s
Equity Securities in a public offering or (b) to venture capital investors so long as Borrower identifies to Lender and Collateral
Agent the venture capital investors prior to the execution of a definitive agreement relating to such change of ownership and
any such venture capital investors that purchase or otherwise acquire twenty-five percent (25%) or more of the ownership of Borrower
in one or a series of transactions have cleared Lender’s “know your customer” checks.

 

7.8
Transactions With Affiliates; Creation of Subsidiaries. (a) Enter, or permit any Subsidiary to enter, into any contractual
obligation with any Affiliate or engage in any other transaction with any Affiliate except upon terms at least as favorable to
Borrower or such Subsidiary, as applicable, as an arms-length transaction with Persons who are not Affiliates of Borrower or (b)
create a Subsidiary without providing at least 10 Business Days advance notice thereof to Lender and, if requested by Lender,
such Subsidiary guarantees the Obligations and grants a security interest in its assets to secure such guaranty, in each case
on terms reasonably satisfactory to Collateral Agent and Lender.

 

7.9
Indebtedness Payments. (a) Prepay, redeem, purchase, defease or otherwise satisfy in any manner prior to the scheduled
repayment thereof any Indebtedness for borrowed money (other than amounts due or permitted to be prepaid under this Agreement)
or lease obligations, (b) amend, modify or otherwise change the terms of any Indebtedness for borrowed money or lease obligations
so as to accelerate the scheduled repayment thereof or (c) repay any notes to officers, directors or shareholders.

 

7.10
Indebtedness. Create, incur, assume or permit, or permit any Subsidiary to create, incur, or permit to exist, any Indebtedness
except Permitted Indebtedness.

 

7.11
Investments. Make, or permit any Subsidiary to make, any Investment except for Permitted Investments.

 

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7.12
Compliance. (a) Become, or permit any Subsidiary to become, an “investment company” or a company controlled
by an “investment company” under the Investment Company Act of 1940, or undertake as one of its important activities,
extending credit to purchase or carry margin stock (as defined in Regulation U of the Board of Governors of the Federal Reserve
System), or use the proceeds of any Loan for that purpose; (b) become, or permit any Subsidiary to become, subject to any other
federal or state law or regulation which purports to restrict or regulate its ability to borrow money; or (c) (i) fail, or permit
any Subsidiary to fail, to meet the minimum funding requirements of the Employment Retirement Income Security Act of 1974, and
its regulations, as amended from time to time (“ERISA”), permit, or (ii) permit, or permit any Subsidiary to permit,
a Reportable Event or Prohibited Transaction, as defined in ERISA, to occur; (d) fail, or permit any Subsidiary to fail, to comply
with the Federal Fair Labor Standards Act or violate any other law or regulation, if the violation could reasonably be expected
to have Material Adverse Effect.

 

7.13
Maintenance of Accounts. (a) Maintain any deposit account or securities account except accounts with respect to which Collateral
Agent and Lender has obtained a perfected security interest in such accounts through one or more Account Control Agreements or
(b) grant or allow any other Person (other than Collateral Agent or Lender) to perfect a security interest in, or enter into any
agreements with any Persons (other than Collateral Agent or Lender) accomplishing perfection via control as to, any of its deposit
accounts or securities accounts.

 

7.14
Negative Pledge Regarding Intellectual Property. Create, incur, assume or suffer to exist, or permit any Subsidiary to
create, incur, assume or suffer to exist, any Lien of any kind upon any Intellectual Property or Transfer any Intellectual Property,
whether now owned or hereafter acquired, other than non-exclusive licenses of Intellectual Property entered into in the ordinary
course of business.

 

8.
Events of Default. Any one or more of the following events shall constitute an “Event of Default” by
Borrower under this Agreement:

 

8.1
Failure to Pay. If Borrower fails to pay when due and payable or when declared due and payable in accordance with the Loan
Documents: (a) any Scheduled Payment on the relevant Payment Date or on the relevant Maturity Date; or (b) any other portion of
the Obligations within five (5) days after receipt of written notice from Lender that such payment is due.

 

8.2
Certain Covenant Defaults. If Borrower fails to perform any obligation arising under Sections 6.5, 6.8 or 6.12 or violates
any of the covenants contained in Section 7 of this Agreement.

 

8.3
Other Covenant Defaults. If Borrower fails or neglects to perform, keep, or observe any other term, provision, condition,
covenant, or agreement contained in this Agreement (other than as set forth in Sections 8.1, 8.2 or 8.4 through 8.14), in any
of the other Loan Documents and Borrower has failed to cure such default within thirty (30) days of the occurrence of such default.
During this thirty (30) day period, the failure to cure the default is not an Event of Default.

 

8.4
Material Adverse Change. If there occurs a material adverse change in Borrower’s business, or if there is a material
impairment of the prospect of repayment of any portion of the Obligations owing to Collateral Agent or Lender or a material impairment
of the value or priority of Collateral Agent’s and Lender’s security interest in the Collateral.

 

8.5
Investor Abandonment. If Lender determines in its reasonable good faith judgment, that it is the clear intention of Borrower’s
investors not to continue to fund Borrower in the amounts and within the timeframe necessary to enable Borrower to satisfy the
Obligations as they become due and payable.

 

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8.6
Seizure of Assets, Etc. (a) If any material portion of Borrower’s or any Subsidiary’s assets (i) is attached,
seized, subjected to a writ or distress warrant, or is levied upon or (ii) comes into the possession of any trustee, receiver
or Person acting in a similar capacity and such attachment, seizure, writ or distress warrant or levy has not been removed, discharged
or rescinded within ten (10) days, (b) if Borrower or any Subsidiary is enjoined, restrained or in any way prevented by court
order from continuing to conduct all or any material part of its business affairs, (c) if a judgment or other claim becomes a
lien or encumbrance upon any material portion of Borrower’s or any Subsidiary’s assets or (d) if a notice of lien,
levy, or assessment is filed of record with respect to any of Borrower’s or any Subsidiary’s assets by the United
States Government, or any department agency or instrumentality thereof, or by any state, county, municipal, or governmental agency,
and the same is not paid within ten (10) days after Borrower receives notice thereof; provided that none of the foregoing
shall constitute an Event of Default where such action or event is stayed or an adequate bond has been posted pending a good faith
contest by Borrower.

 

8.7
Service of Process. (a) The service of process upon Collateral Agent or Lender seeking to attach by a trustee or other
process any funds of Borrower on deposit or otherwise held by Collateral Agent or Lender, (b) the delivery upon Collateral Agent
or Lender of a notice of foreclosure by any Person seeking to attach or foreclose on any funds of Borrower on deposit or otherwise
held by Collateral Agent or Lender or (c) the delivery of a notice of foreclosure or exclusive control to any entity holding or
maintaining Borrower’s deposit accounts or accounts holding securities by any Person (other than Collateral Agent or Lender)
seeking to foreclose or attach any such accounts or securities.

 

8.8
Default on Indebtedness. One or more defaults shall exist under any agreement with any third party or parties which consists
of the failure to pay any Indebtedness of Borrower or any Subsidiary at maturity or which results in a right by such third party
or parties, whether or not exercised, to accelerate the maturity of Indebtedness in an aggregate amount in excess of Fifty Thousand
Dollars ($50,000) or a default shall exist under any financing agreement with a Lender or any Lender’s Affiliates.

 

8.9
Judgments. If a judgment or judgments for the payment of money in an amount, individually or in the aggregate, of at least
Fifty Thousand Dollars ($50,000) shall be rendered against Borrower or any Subsidiary and shall remain unsatisfied and unstayed
for a period of ten (10) days or more.

 

8.10
Misrepresentations. If any material misrepresentation or material misstatement exists now or hereafter in any warranty,
representation, statement, certification, or report made to Collateral Agent or Lender by Borrower or any officer, employee, agent,
or director of Borrower.

 

8.11
Breach of Warrant. If Borrower shall breach any material term of any Warrant.

 

8.12
Unenforceable Loan Document. If any Loan Document shall in any material respect cease to be as determined by a final non-appealable
binding judgment, or Borrower shall assert that any Loan Document is not, a legal, valid and binding obligation of Borrower enforceable
in accordance with its terms.

 

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8.13
Involuntary Insolvency Proceeding. (a) If a proceeding shall have been instituted in a court having jurisdiction in the
premises (i) seeking a decree or order for relief in respect of Borrower or any Subsidiary in an involuntary case under any applicable
bankruptcy, insolvency or other similar law now or hereafter in effect, (ii) for the appointment of a receiver, liquidator, administrator,
assignee, custodian, trustee (or similar official) of Borrower or any Subsidiary or for any substantial part of its Property or
(iii) for the winding-up or liquidation of its affairs, and such proceeding shall remain undismissed or unstayed and in effect
for a period of thirty (30) consecutive days or (b) such court shall enter a decree or order granting the relief sought in any
such proceeding.

 

8.14
Voluntary Insolvency Proceeding. If Borrower or any Subsidiary shall (a) commence a voluntary case under any applicable
bankruptcy, insolvency or other similar law now or hereafter in effect, (b) consent to the entry of an order for relief in an
involuntary case under any such law, (c) consent to the appointment of or taking possession by a receiver, liquidator, assignee,
trustee, custodian (or other similar official) of Borrower or any Subsidiary or for any substantial part of its Property, (d)
shall make a general assignment for the benefit of creditors, (e) shall fail generally to pay its debts as they become due or
(f) take any corporate action in furtherance of any of the foregoing.

 

9.
Lender’s Rights and Remedies.

 

9.1
Rights and Remedies. Upon the occurrence of any Default or Event of Default, Lender shall not have any further obligation
to advance money or extend credit to or for the benefit of Borrower. In addition, upon the occurrence of an Event of Default,
Collateral Agent and Lender shall have the rights, options, duties and remedies of a secured party as permitted by law and, in
addition to and without limitation of the foregoing, Collateral Agent, on behalf of Lender, or Lender (acting alone) may, at its
election, without notice of election and without demand, do any one or more of the following, all of which are authorized by Borrower:

 

(a)
Acceleration of Obligations. Declare all Obligations, whether evidenced by this Agreement, by any of the other Loan Documents,
or otherwise, including (i) any accrued and unpaid interest, (ii) the amounts which would have otherwise come due under Section
2.3(b)(ii) if the Loans had been voluntarily prepaid, (iii) the unpaid principal balance of the Loans and (iv) all other sums,
if any, that shall have become due and payable hereunder, immediately due and payable (provided that upon the occurrence
of an Event of Default described in Section 8.13 or 8.14 all Obligations shall become immediately due and payable without
any action by Collateral Agent or Lender);

 

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(b)
Protection of Collateral. Make such payments and do such acts as Collateral Agent or Lender considers necessary or reasonable
to protect Collateral Agent’s and Lender’s security interest in the Collateral. Borrower agrees to assemble the Collateral
if Collateral Agent or Lender so requires and to make the Collateral available to Collateral Agent or Lender as Collateral Agent
or Lender may designate. Borrower authorizes Collateral Agent, Lender and their designees and agents to enter the premises where
the Collateral is located, to take and maintain possession of the Collateral, or any part of it, and to pay, purchase, contest,
or compromise any Lien which in Collateral Agent’s or Lender’s determination appears or is claimed to be prior or
superior to its security interest and to pay all expenses incurred in connection therewith. With respect to any of Borrower’s
owned premises, Borrower hereby grants Collateral Agent and Lender a license to enter into possession of such premises and to
occupy the same, without charge, for up to one hundred twenty (120) days in order to exercise any of Collateral Agent’s
and Lender’s rights or remedies provided herein, at law, in equity, or otherwise;

 

(c)
Preparation of Collateral for Sale. Ship, reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise
for sale, and sell (in the manner provided for herein) the Collateral. Collateral Agent, Lender and their agents and any purchasers
at or after foreclosure are hereby granted a non-exclusive, irrevocable, perpetual, fully paid, royalty-free license or other
right, solely pursuant to the provisions of this Section 9.1, to use, without charge, Borrower’s Intellectual Property,
including labels, patents, copyrights, rights of use of any name, trade secrets, trade names, trademarks, service marks, and advertising
matter, or any Property of a similar nature, now or at any time hereafter owned or acquired by Borrower or in which Borrower now
or at any time hereafter has any rights; provided that such license shall only be exercisable in connection with the disposition
of Collateral upon Collateral Agent’s or Lender’s exercise of its remedies hereunder;

 

(d)
Sale of Collateral. Sell the Collateral at either a public or private sale, or both, by way of one or more contracts or
transactions, for cash or on terms, in such manner and at such places (including Borrower’s premises) as Collateral Agent
or Lender determines are commercially reasonable; and

 

(e)
Purchase of Collateral. Credit bid and purchase all or any portion of the Collateral at any public sale.

 

Any
deficiency that exists after disposition of the Collateral as provided above will be paid immediately by Borrower.

 

9.2
Set Off Right. Collateral Agent and Lender may set off and apply to the Obligations any and all Indebtedness at any time
owing to or for the credit or the account of Borrower or any other assets of Borrower in Collateral Agent’s or Lender’s
possession or control.

 

9.3
Effect of Sale. Upon the occurrence of an Event of Default, to the extent permitted by law, Borrower covenants that it
will not at any time insist upon or plead, or in any manner whatsoever claim or take any benefit or advantage of, any stay or
extension law now or at any time hereafter in force, nor claim, take nor insist upon any benefit or advantage of or from any law
now or hereafter in force providing for the valuation or appraisement of the Collateral or any part thereof prior to any sale
or sales thereof to be made pursuant to any provision herein contained, or to the decree, judgment or order of any court of competent
jurisdiction; nor, after such sale or sales, claim or exercise any right under any statute now or hereafter made or enacted by
any state or otherwise to redeem the property so sold or any part thereof, and, to the full extent legally permitted, except as
to rights expressly provided herein, hereby expressly waives for itself and on behalf of each and every Person, except decree
or judgment creditors of Borrower, acquiring any interest in or title to the Collateral or any part thereof subsequent to the
date of this Agreement, all benefit and advantage of any such law or laws, and covenants that it will not invoke or utilize any
such law or laws or otherwise hinder, delay or impede the execution of any power herein granted and delegated to Collateral Agent
or Lender, but will suffer and permit the execution of every such power as though no such power, law or laws had been made or
enacted. Any sale, whether under any power of sale hereby given or by virtue of judicial proceedings, shall operate to divest
all right, title, interest, claim and demand whatsoever, either at law or in equity, of Borrower in and to the Property sold,
and shall be a perpetual bar, both at law and in equity, against Borrower, its successors and assigns, and against any and all
Persons claiming the Property sold or any part thereof under, by or through Borrower, its successors or assigns.

 

    	31

    	 

    

 

9.4
Power of Attorney in Respect of the Collateral. Borrower does hereby irrevocably appoint Collateral Agent, on behalf of
Lender (which appointment is coupled with an interest) the true and lawful attorney in fact of Borrower, with full power of substitution
and in its name to file any notices of security interests, financing statements and continuations and amendments thereof pursuant
to the Code or federal law, as may be necessary to perfect or to continue the perfection of Collateral Agent’s and Lender’s
security interests in the Collateral. Borrower does hereby irrevocably appoint Collateral Agent, on behalf of Lender (which appointment
is coupled with an interest) on the occurrence of an Event of Default, the true and lawful attorney in fact of Borrower, with
full power of substitution and in its name: (a) to ask, demand, collect, receive, receipt for, sue for, compound and give acquittance
for any and all rents, issues, profits, avails, distributions, income, payment draws and other sums in which a security interest
is granted under Section 4 with full power to settle, adjust or compromise any claim thereunder as fully as if Collateral Agent
or Lender were Borrower itself; (b) to receive payment of and to endorse the name of Borrower to any items of Collateral (including
checks, drafts and other orders for the payment of money) that come into Collateral Agent’s or Lender’s possession
or under Collateral Agent’s or Lender’s control; (c) to make all demands, consents and waivers, or take any other
action with respect to, the Collateral; (d) in Collateral Agent’s or Lender’s discretion to file any claim or take
any other action or proceedings, either in its own name or in the name of Borrower or otherwise, which Collateral Agent or Lender
may reasonably deem necessary or appropriate to protect and preserve the right, title and interest of Collateral Agent and Lender
in and to the Collateral; (e) endorse Borrower’s name on any checks or other forms of payment or security; (f) sign Borrower’s
name on any invoice or bill of lading for any account or drafts against account debtors; (g) make, settle, and adjust all claims
under Borrower’s insurance policies; (h) settle and adjust disputes and claims about the accounts directly with account
debtors, for amounts and on terms Collateral Agent or Lender determines reasonable; (i) transfer the Collateral into the name
of Collateral Agent, Lender or a third party as the Code permits; and (j) to otherwise act with respect thereto as though Collateral
Agent or Lender were the outright owner of the Collateral.

 

9.5
Lender’s Expenses. If Borrower fails to pay any amounts or furnish any required proof of payment due to third persons
or entities, as required under the terms of this Agreement, then Collateral Agent or Lender may do any or all of the following:
(a) make payment of the same or any part thereof; or (b) obtain and maintain insurance policies of the type discussed in Section
6.8 of this Agreement, and take any action with respect to such policies as Collateral Agent or Lender deems prudent. Any amounts
paid or deposited by Collateral Agent or Lender shall constitute Lender’s Expenses, shall be immediately due and payable,
shall bear interest at the Default Rate and shall be secured by the Collateral. Any payments made by Collateral Agent or Lender
shall not constitute an agreement by Collateral Agent or Lender to make similar payments in the future or a waiver by Collateral
Agent or Lender of any Event of Default under this Agreement. Borrower shall pay all reasonable fees and expenses, including Lender’s
Expenses, incurred by Collateral Agent or Lender in the enforcement or attempt to enforce any of the Obligations hereunder not
performed when due.

 

    	32

    	 

    

 

9.6
Remedies Cumulative; Independent Nature of Lender’s Rights. Collateral Agent’s and Lender’s rights and
remedies under this Agreement, the Loan Documents, and all other agreements shall be cumulative. Collateral Agent and Lender shall
have all other rights and remedies not inconsistent herewith as provided under the Code, by law, or in equity. No failure on the
part of Collateral Agent or Lender to exercise, and no delay in exercising, any right or remedy hereunder shall operate as a waiver
thereof; nor shall any single or partial exercise of any such right or remedy preclude any other or further exercise thereof or
the exercise of any other right. The Obligations of Borrower to Lender or Collateral Agent may be enforced by Lender or Collateral
Agent against Borrower in accordance with the terms of this Agreement and the other Loan Documents and, to the fullest extent
permitted by applicable law, it shall not be necessary for Collateral Agent or Lender, as applicable, to be joined as an additional
party in any proceeding to enforce such Obligations.

 

9.7
Application of Collateral Proceeds. The proceeds and/or avails of the Collateral, or any part thereof, and the proceeds
and the avails of any remedy hereunder (as well as any other amounts of any kind held by Collateral Agent or Lender, at the time
of or received by Collateral Agent or Lender after the occurrence of an Event of Default hereunder) shall be paid to and applied
as follows:

 

(a)
First, to the payment of out-of-pocket costs and expenses, including all amounts expended to preserve the value of the
Collateral, of foreclosure or suit, if any, and of such sale and the exercise of any other rights or remedies, and of all proper
fees, expenses, liability and advances, including reasonable legal expenses and attorneys’ fees, incurred or made hereunder
by Collateral Agent or Lender, including Lender’s Expenses;

 

(b)
Second, to the payment to Lender of the amount then owing or unpaid on the Loans for any accrued and unpaid interest, the
amounts which would have otherwise come due under Section 2.3(b)(ii), if the Loans had been voluntarily prepaid, the principal
balance of the Loans, and all other Obligations with respect to the Loans (provided, however, if such proceeds shall be
insufficient to pay in full the whole amount so due, owing or unpaid upon the Loans, then first, to the unpaid interest
thereon ratably, second, to the amounts which would have otherwise come due under Section 2.3(b)(ii) ratably, if
the Loans had been voluntarily prepaid, third, to the principal balance of the Loans ratably, and fourth, to the
ratable payment of other amounts then payable to Lender under any of the Loan Documents); and

 

(c)
Third, to the payment of the surplus, if any, to Borrower, its successors and assigns or to the Person lawfully entitled
to receive the same.

 

    	33

    	 

    

 

9.8
Reinstatement of Rights. If Collateral Agent or Lender shall have proceeded to enforce any right under this Agreement or
any other Loan Document by foreclosure, sale, entry or otherwise, and such proceedings shall have been discontinued or abandoned
for any reason or shall have been determined adversely, then and in every such case (unless otherwise ordered by a court of competent
jurisdiction), Collateral Agent and Lender shall be restored to their former position and rights hereunder with respect to the
Property subject to the security interest created under this Agreement.

 

10.
Waivers; Indemnification.

 

10.1
Demand; Protest. Borrower waives demand, protest, notice of protest, notice of default or dishonor, notice of payment and
nonpayment, notice of any default, nonpayment at maturity, release, compromise, settlement, extension, or renewal of accounts,
documents, instruments, chattel paper, and guarantees at any time held by Collateral Agent or Lender on which Borrower may in
any way be liable.

 

10.2
Lender’s Liability for Collateral. So long as Collateral Agent and Lender comply with their obligations, if any,
under the Code, neither Collateral Agent nor Lender shall in any way or manner be liable or responsible for: (a) the safekeeping
of the Collateral; (b) any loss or damage thereto occurring or arising in any manner or fashion from any cause other than Collateral
Agent’s or Lender’s gross negligence or willful misconduct; (c) any diminution in the value thereof; or (d) any act
or default of any carrier, warehouseman, bailee, forwarding agency, or other Person whomsoever. All risk of loss, damage or destruction
of the Collateral shall be borne by Borrower.

 

10.3
Indemnification and Waiver. Whether or not the transactions contemplated hereby shall be consummated:

 

(a)
General Indemnity. Borrower agrees upon demand to pay or reimburse Collateral Agent and Lender for all liabilities, obligations
and out-of-pocket expenses, including Lender’s Expenses and reasonable fees and expenses of counsel for Collateral Agent
and Lender from time to time arising in connection with the enforcement or collection of sums due under the Loan Documents, and
in connection with any amendment or modification of the Loan Documents or any “work-out” in connection with the Loan
Documents. Borrower shall indemnify, reimburse and hold Collateral Agent, Lender, and each of their respective successors, assigns,
agents, attorneys, officers, directors, equity holders, servants, agents and employees (each an “Indemnified Person”)
harmless from and against all liabilities, losses, damages, actions, suits, demands, claims of any kind and nature (including
claims relating to environmental discharge, cleanup or compliance), all costs and expenses whatsoever to the extent they may be
incurred or suffered by such Indemnified Person in connection therewith (including reasonable attorneys’ fees and expenses),
fines, penalties (and other charges of any applicable Governmental Authority), licensing fees relating to any item of Collateral,
damage to or loss of use of property (including consequential or special damages to third parties or damages to Borrower’s
property), or bodily injury to or death of any person (including any agent or employee of Borrower) (each, a “Claim”),
directly or indirectly relating to or arising out of the use of the proceeds of the Loans or otherwise, the falsity of any representation
or warranty of Borrower or Borrower’s failure to comply with the terms of this Agreement or any other Loan Document. The
foregoing indemnity shall cover, without limitation, (i) any Claim in connection with a design or other defect (latent or patent)
in any item of equipment or product included in the Collateral, (ii) any Claim for infringement of any patent, copyright, trademark
or other intellectual property right, (iii) any Claim resulting from the presence on or under or the escape, seepage, leakage,
spillage, discharge, emission or release of any Hazardous Materials on the premises owned, occupied or leased by Borrower, including
any Claims asserted or arising under any Environmental Law, (iv) any Claim for negligence or strict or absolute liability in tort
or (v) any Claim asserted as to or arising under any Account Control Agreement or any Landlord Agreement; provided, however,
Borrower shall not indemnify any Indemnified Person for any liability incurred by such Indemnified Person as a direct and sole
result of such Indemnified Person’s gross negligence or willful misconduct. Such indemnities shall continue in full force
and effect, notwithstanding the expiration or termination of this Agreement. Upon Collateral Agent’s or Lender’s written
demand, Borrower shall assume and diligently conduct, at its sole cost and expense, the entire defense of Collateral Agent and
Lender, each of their members, partners, and each of their respective, agents, employees, directors, officers, equity holders,
successors and assigns against any indemnified Claim described in this Section 10.3(a). Borrower shall not settle or compromise
any Claim against or involving Collateral Agent or Lender without first obtaining Collateral Agent’s or Lender’s written
consent thereto, which consent shall not be unreasonably withheld.

 

    	34

    	 

    

 

(b)
Waiver. NOTWITHSTANDING ANYTHING TO THE CONTRARY CONTAINED IN THIS AGREEMENT OR ANYWHERE ELSE, BORROWER AGREES THAT IT
SHALL NOT SEEK FROM COLLATERAL AGENT OR LENDER UNDER ANY THEORY OF LIABILITY (INCLUDING ANY THEORY IN TORTS), ANY SPECIAL, INDIRECT,
CONSEQUENTIAL OR PUNITIVE DAMAGES.

 

(c)
Survival; Defense. The obligations in this Section 10.3 shall survive payment of all other Obligations pursuant
to Section 12.8. At the election of any Indemnified Person, Borrower shall defend such Indemnified Person using legal counsel
satisfactory to such Indemnified Person in such Person’s reasonable discretion, at the sole cost and expense of Borrower.
All amounts owing under this Section 10.3 shall be paid within thirty (30) days after written demand.

 

11.
Notices. Unless otherwise provided in this Agreement, all notices or demands by any party relating to this Agreement or
any other agreement entered into in connection herewith shall be in writing and (except for financial statements and other informational
documents which may be sent by first-class mail, postage prepaid) shall be personally delivered or sent by certified mail, postage
prepaid, return receipt requested, by prepaid nationally recognized overnight courier, or by prepaid facsimile to Borrower or
to Lender, as the case may be, at their respective addresses set forth below:

 

	 	If
    to Borrower:	Celsion
    Corporation
	 	 	997
    Lenox drive, Suite 100
	 	 	Lawrenceville,
    NJ 08648
	 	 	Attention: Michael H. Tardugno

                                                                                        Chairman, President & CEO

	 	 	Fax:
    (609) 896-2200
	 	 	Ph:
    (609) 896-9100

 

	 	If
    to Horizon:	Horizon
    Technology Finance Corporation
	 	 	312
    Farmington Avenue
	 	 	Farmington,
    CT 06032
	 	

                                                                                 
	Attention:
    Legal Department
	 	 	Fax:
    (860) 676-8655
	 	 	Ph:
    (860) 676-8654

 

    	35

    	 

    

 

The
parties hereto may change the address at which they are to receive notices hereunder, by notice in writing in the foregoing manner
given to the other.

 

12.
General Provisions.

 

12.1
Successors and Assigns. This Agreement and the Loan Documents shall bind and inure to the benefit of the respective successors
and permitted assigns of each of the parties; provided, however, neither this Agreement nor any rights hereunder may be
assigned by Borrower without Lender’s prior written consent, which consent may be granted or withheld in Lender’s
sole discretion. Lender shall have the right without the consent of or notice to Borrower to sell, transfer, assign, negotiate,
or grant participations in all or any part of, or any interest in Lender’s rights and benefits hereunder. Collateral Agent
and Lender may disclose the Loan Documents and any other financial or other information relating to Borrower to any potential
participant or assignee of any of the Loans; provided that such participant or assignee agrees to protect the confidentiality
of such documents and information using the same measures that it uses to protect its own confidential information.

 

12.2
Time of Essence. Time is of the essence for the performance of all obligations set forth in this Agreement.

 

12.3
Severability of Provisions. Each provision of this Agreement shall be severable from every other provision of this Agreement
for the purpose of determining the legal enforceability of any specific provision.

 

12.4
Entire Agreement; Construction; Amendments and Waivers.

 

(a)
Entire Agreement. This Agreement and each of the other Loan Documents, taken together, constitute and contain the entire
agreement among Borrower, Collateral Agent and Lender and supersede any and all prior agreements, negotiations, correspondence,
understandings and communications between the parties, whether written or oral, respecting the subject matter hereof. Borrower
acknowledges that it is not relying on any representation or agreement made by Collateral Agent, Lender or any employee, attorney
or agent thereof, other than the specific agreements set forth in this Agreement and the Loan Documents.

 

(b)
Construction. This Agreement is the result of negotiations between and has been reviewed by each of Borrower, Collateral
Agent and Lender as of the date hereof and their respective counsel; accordingly, this Agreement shall be deemed to be the product
of the parties hereto, and no ambiguity shall be construed in favor of or against Borrower, Collateral Agent or Lender. Borrower,
Collateral Agent and Lender agree that they intend the literal words of this Agreement and the other Loan Documents and that no
parol evidence shall be necessary or appropriate to establish Borrower’s, Collateral Agent’s or Lender’s actual
intentions.

 

    	36

    	 

    

 

(c)
Amendments and Waivers. Any and all discharges or waivers of, or consents to any departures from any provision of this
Agreement or of any of the other Loan Documents shall not be effective without the written consent of Lender; provided
that no such discharge, waiver or consent affecting the rights or duties of the Collateral Agent under this Agreement or any other
Loan Document shall be effective without the written consent of the Collateral Agent. Any and all amendments and modifications
of this Agreement or of any of the other Loan Documents shall not be effective without the written consent of Lender and Borrower;
provided that no such amendment or modification affecting the rights or duties of the Collateral Agent under this Agreement
or any other Loan Document shall be effective without the written consent of the Collateral Agent. Any waiver or consent with
respect to any provision of the Loan Documents shall be effective only in the specific instance and for the specific purpose for
which it was given. No notice to or demand on Borrower in any case shall entitle Borrower to any other or further notice or demand
in similar or other circumstances. Any amendment, modification, waiver or consent affected in accordance with this Section
12.4 shall be binding upon Collateral Agent, Lender and on Borrower.

 

12.5
Reliance by Lender. All covenants, agreements, representations and warranties made herein by Borrower shall be deemed to
be material to and to have been relied upon by Collateral Agent and Lender, notwithstanding any investigation by Collateral Agent
or Lender.

 

12.6
No Set-Offs by Borrower. All sums payable by Borrower pursuant to this Agreement or any of the other Loan Documents shall
be payable without notice or demand and shall be payable in United States Dollars without set-off or reduction of any manner whatsoever.

 

12.7
Counterparts. This Agreement may be executed in any number of counterparts and by different parties on separate counterparts
(including signatures delivered by facsimile or other electronic means), each of which, when executed and delivered, shall be
deemed to be an original, and all of which, when taken together, shall constitute but one and the same Agreement.

 

12.8
Survival. All covenants, representations and warranties made in this Agreement shall continue in full force and effect
so long as any Obligations or commitment to fund remain outstanding. The obligations of Borrower to indemnify Collateral Agent
and Lender with respect to the expenses, damages, losses, costs and liabilities described in Section 10.3 shall survive until
all applicable statute of limitations periods with respect to actions that may be brought against Collateral Agent or Lender have
run.

 

13.
Relationship of Parties. Borrower and Lender acknowledge, understand and agree that the relationship between Borrower,
on the one hand, and Lender, on the other, is, and at all times shall remain solely that of a borrower and lender. Lender shall
not, under any circumstances, be construed to be a partner or a joint venturer of Borrower or any of its Affiliates; nor shall
Lender, under any circumstances, be deemed to be in a relationship of confidence or trust or a fiduciary relationship with Borrower
or any of its Affiliates, or to owe any fiduciary duty or any other duty to Borrower or any of its Affiliates. Neither Collateral
Agent nor Lender undertakes or assumes any responsibility or duty to Borrower or any of its Affiliates to select, review, inspect,
supervise, pass judgment upon or otherwise inform Borrower or any of its Affiliates of any matter in connection with its or their
Property, any Collateral held by Collateral Agent or Lender or the operations of Borrower or any of its Affiliates. Borrower and
each of its Affiliates shall rely entirely on their own judgment with respect to such matters, and any review, inspection, supervision,
exercise of judgment or supply of information undertaken or assumed by Collateral Agent or Lender in connection with such matters
is solely for the protection of Collateral Agent and Lender and neither Borrower nor any Affiliate is entitled to rely thereon.

 

    	37

    	 

    

 

14.
Confidentiality. All information (other than periodic reports filed by Borrower with the Securities and Exchange Commission)
disclosed by Borrower to Collateral Agent or Lender in writing or through inspection pursuant to this Agreement that is marked
confidential shall be considered confidential. Collateral Agent and Lender agrees to use the same degree of care to safeguard
and prevent disclosure of such confidential information as Collateral Agent and Lender uses with its own confidential information,
but in any event no less than a reasonable degree of care. Neither Collateral Agent nor Lender shall disclose such information
to any third party (other than (a) to another party hereto, (b) to Collateral Agent’s or Lender’s members, partners,
attorneys, governmental regulators (including any self-regulatory authority) or auditors, (c) to Collateral Agent’s or Lender’s
subsidiaries and affiliates, (d) on a confidential basis, to any rating agency, (e) to prospective transferees and purchasers
of the Loans or any actual or prospective party (or its Affiliates) to any swap, derivative or other transaction under which payments
are to be made by reference to the Obligations, Borrower, any Loan Document or any payment thereunder, all subject to the same
confidentiality obligation set forth herein or (f) as required by law, regulation, subpoena or other order to be disclosed) and
shall use such information only for purposes of evaluation of its investment in Borrower and the exercise of Collateral Agent’s
or Lender’s rights and the enforcement of its remedies under this Agreement and the other Loan Documents. The obligations
of confidentiality shall not apply to any information that (i) was known to the public prior to disclosure by Borrower under this
Agreement, (ii) becomes known to the public through no fault of Collateral Agent or Lender, (iii) is disclosed to Collateral Agent
or Lender on a non-confidential basis by a third party or (iv) is independently developed by Collateral Agent or Lender. Notwithstanding
the foregoing, Collateral Agent’s and Lender’s agreement of confidentiality shall not apply if Collateral Agent or
Lender has acquired indefeasible title to any Collateral or in connection with any enforcement or exercise of Collateral Agent’s
or Lender’s rights and remedies under this Agreement following an Event of Default, including the enforcement of Collateral
Agent’s and Lender’s security interest in the Collateral.

 

15.
CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER. THIS AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED AND ENFORCED IN ACCORDANCE
WITH, THE LAWS OF THE STATE OF CONNECTICUT. EACH OF BORROWER, COLLATERAL AGENT AND LENDER HEREBY SUBMITS TO THE NON-EXCLUSIVE
JURISDICTION OF THE STATE AND FEDERAL COURTS LOCATED IN THE STATE OF CONNECTICUT. BORROWER, COLLATERAL AGENT AND LENDER HEREBY
WAIVE THEIR RESPECTIVE RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF ANY OF THE LOAN DOCUMENTS
OR ANY OF THE TRANSACTIONS CONTEMPLATED THEREIN, INCLUDING CONTRACT CLAIMS, TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER
COMMON LAW OR STATUTORY CLAIMS.

 

[Remainder
of page intentionally left blank.]

 

    	38

    	 

    

 

IN
WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the date first above written.

 

	 	BORROWER:
	 	CELSION
    CORPORATION
	 	 	 
	 	By:	 
	 	Name:	 
	 	Title:	 
	 	 	 
	 	LENDER:
	 	HORIZON
    TECHNOLOGY FINANCE CORPORATION
	 	 	 
	 	By:	
	 	Name:	Robert
    D. Pomeroy, Jr.
	 	Title:	Chief
    Executive Officer

 

[SIGNATURE
PAGE TO VENTURE LOAN AND SECURITY AGREEMENT]

 

    	 

    	 

    

 

LIST
OF EXHIBITS AND SCHEDULES

 

	Exhibit
    A	Disclosure
Schedule
	Exhibit
    B	Funding
Certificate
	Exhibit
    C	Form
of Note
	Exhibit
    D	Form
of Legal Opinion
	Exhibit
    E	Form
of Officer’s Certificate

 

    	 

    	 

    

 

EXHIBIT
A

 

DISCLOSURE
SCHEDULE

 

[Provided
separately – to be inserted upon completion]

 

    	 

    	 

    

 

EXHIBIT
B

 

FUNDING
CERTIFICATE

 

The
undersigned, being the duly elected and acting of CELSION CORPORATION, a Delaware corporation (“Borrower”), does hereby
certify to HORIZON TECHNOLOGY FINANCE CORPORATION (“Horizon” or “Lender”) in connection with that certain
Venture Loan and Security Agreement dated as of June __, 2018 by and among Borrower, Lender and Horizon as Collateral Agent (the
“Loan Agreement”; with other capitalized terms used below having the meanings ascribed thereto in the Loan Agreement)
that:

 

1.
The representations and warranties made by Borrower in Section 5 of the Loan Agreement and in the other Loan Documents
are true and correct as of the date hereof.

 

2.
No event or condition has occurred that would constitute a Default or an Event of Default under the Loan Agreement or any other
Loan Document.

 

3.
Borrower is in compliance with the covenants and requirements contained in Sections 4, 6 and 7 of the Loan Agreement.

 

4.
All conditions referred to in Section 3 of the Loan Agreement to the making of the Loan to be made on or about the date
hereof have been satisfied.

 

5.
No material adverse change in the general affairs, management, results of operations, condition (financial or otherwise) or prospects
of Borrower, whether or not arising from transactions in the ordinary course of business, has occurred.

 

6.
The proceeds for Loan A, Loan B, Loan C and Loan D shall be disbursed as follows:

 

	 	Disbursement
    from Horizon:	 
	 	Loan
    Amount	$
	 	Less:	 
	 	Legal
    Fees	$
	 	Balance
    of Commitment Fee	$
	 	Net
    Proceeds due from Horizon:	$

 

    	 

    	 

    

 

7.
The aggregate net proceeds of Loan A, Loan B, Loan C and Loan D in the amount of $_________________ shall be transferred by Horizon
to Borrower’s account as follows:

 

Account
Name:

Bank
Name:

Bank
Address:

Attention:

Telephone:

Account
Number:

ABA
Number:

 

	Dated:
June __, 2018	 
	 	 
	 	BORROWER:
	 	 	 
	 	CELSION
    CORPORATION
	 	 	 
	 	By:	             
	 	Name:	
	 	Title:	

 

[Signature page to Funding Certificate]

 

    	 

    	 

    

 

EXHIBIT
C

 

SECURED
PROMISSORY NOTE

 

(Loan
A/B/C/D)

 

	$2,500,000	Dated:
    June __, 2018

 

FOR
VALUE RECEIVED, the undersigned, CELSION CORPORATION, a Delaware corporation (“Borrower”), HEREBY PROMISES
TO PAY to HORIZON TECHNOLOGY FINANCE CORPORATION, a Delaware corporation (“Lender”) the principal amount of
Five Million Dollars ($5,000,000) or such lesser amount as shall equal the outstanding principal balance of Loan [_] (the “Loan”)
made to Borrower by Lender pursuant to the Loan Agreement (as defined below), and to pay all other amounts due with respect to
the Loan on the dates and in the amounts set forth in the Loan Agreement. Capitalized terms used but not defined herein shall
have the meaning ascribed thereto in the Loan Agreement.

 

Interest
on the principal amount of this Note from the date of this Note shall accrue at the Loan Rate or, if applicable, the Default Rate,
each as established in accordance with the Loan Agreement (as defined below). Interest shall be computed on the basis of a 360-day
year for the actual number of days elapsed. If the Funding Date is not the first day of the month, interim interest accruing from
the Funding Date through the last day of that month shall be paid on the first calendar day of the next calendar month. Commencing
[_], 201[_], through and including [_], 201[_], on the first day of each month (each an “Interest Payment Date”)
Borrower shall make payments of accrued interest only on the outstanding principal amount of the Loan. Commencing on [_], 201[_],
and continuing on the first day of each month thereafter (each a “Principal and Interest Payment Date” and,
collectively with each Interest Payment Date, each a “Payment Date”), Borrower shall make to Lender twenty-four
(24) equal payments of principal in the amount of [______________] plus accrued interest on the then outstanding principal amount
due hereunder. On the earliest to occur of (i) [_], 201[_], (ii) payment in full of the principal balance of the Loan or (iii)
an Event of Default and demand by Lender of payment in full of the Loan, Borrower shall make a payment of Two Hundred Thousand
and 00/100 Dollars ($200,000) to Lender (the “Final Payment”). If not sooner paid, all outstanding amounts
hereunder and under the Loan Agreement shall become due and payable on [_], 201[_].

 

Principal,
interest and all other amounts due with respect to the Loan, are payable in lawful money of the United States of America to Lender
as set forth in the Loan Agreement. The principal amount of this Note and the interest rate applicable thereto, and all payments
made with respect thereto, shall be recorded by Lender and, prior to any transfer hereof, endorsed on the grid attached hereto
which is part of this Note.

 

This
Note is referred to in, and is entitled to the benefits of, the Venture Loan and Security Agreement dated as of the date hereof
(the “Loan Agreement”), among Borrower, Lender and Lender as Collateral Agent. The Loan Agreement, among other
things, (a) provides for the making of a secured Loan to Borrower, and (b) contains provisions for acceleration of the maturity
hereof upon the happening of certain stated events.

 

This
Note may not be prepaid, except as set forth in Section 2.3 of the Loan Agreement.

 

    	 

    	 

    

 

This
Note and the obligation of Borrower to repay the unpaid principal amount of the Loan, interest on the Loan and all other amounts
due Lender under the Loan Agreement is secured under the Loan Agreement.

 

Presentment
for payment, demand, notice of protest and all other demands and notices of any kind in connection with the execution, delivery,
performance and enforcement of this Note are hereby waived.

 

Borrower
shall pay all fees and expenses, including attorneys’ fees and costs, incurred by Lender in the enforcement or attempt to
enforce any of Borrower’s obligations hereunder not performed when due.

 

Any
reference herein to Lender shall be deemed to include and apply to every subsequent holder of this Note. Reference is made to
the Loan Agreement for provisions concerning optional and mandatory prepayments, Collateral, acceleration and other material terms
affecting this Note.

 

This
Note shall be governed by and construed under the laws of the State of Connecticut. Borrower agrees that any action or proceeding
brought to enforce or arising out of this Note may be commenced in the state or federal courts located within the State of Connecticut.

 

IN
WITNESS WHEREOF, Borrower has caused this Note to be duly executed by one of its officers thereunto duly authorized on the date
hereof.

 

	 	BORROWER:
	 	 	 
	 	CELSION
    CORPORATION
	 	 	 
	 	By:	             
	 	Name:	 
	 	Title:	

 

[SIGNATURE PAGE TO SECURED PROMISSORY NOTE (LOAN [A/B/C/D])]

 

    	 

    	 

    

 

EXHIBIT
D

 

ITEMS
TO BE COVERED BY OPINION OF BORROWER’S COUNSEL

 

1.
Borrower is a corporation, duly organized, validly existing and in good standing under the laws of the State of Delaware, and
is duly qualified and authorized to do business in the State of New Jersey.

 

2.
Borrower has the full corporate power, authority and legal right, and has obtained all necessary approvals, consents and given
all notices to execute and deliver the Loan Documents and perform the terms thereof.

 

3.
The Loan Documents have been duly authorized, executed and delivered by Borrower and constitute valid, legal and binding agreements,
and are enforceable in accordance with their terms.

 

4.
To our knowledge, there is no action, suit, audit, investigation, proceeding or patent claim pending or threatened against Borrower
in any court or before any governmental commission, agency, board or authority which might have a Material Adverse Effect.

 

5.
The Shares (as defined in the Warrant) issuable pursuant to exercise or conversion of the Warrant have been duly authorized and
reserved for issuance by Borrower and, when issued in accordance with the terms thereof, will be validly issued, fully paid and
nonassessable.

 

6.
The shares of Common Stock issuable upon conversion of the Shares have been duly authorized and reserved and, when issued in accordance
with the terms of Borrower’s Certificate of Incorporation, as amended, will be validly issued, fully paid and nonassessable.

 

7.
The execution and delivery of the Loan Documents are not, and the issuance of the Shares upon exercise of the Warrant in accordance
with the terms thereof will not be, inconsistent with Borrower’s Certificate of Incorporation, as amended, or Bylaws, do
not and will not contravene any law, governmental rule or regulation, judgment or order applicable to Borrower, and do not and
will not conflict with or contravene any provision of, or constitute a default under, any indenture, mortgage, contract or other
agreement or instrument of which Borrower is a party or by which it is bound or require the consent or approval of, the giving
of notice to, the registration or filing with or the taking of any action in respect of or by, any federal, state or local government
authority or agency or other person, except for the filing of notices pursuant to federal and state securities laws, which filings
will be effected by the time required thereby.

 

    	 

    	 

    

 

EXHIBIT
E

 

FORM
OF OFFICER’S CERTIFICATE

 

	TO:	HORIZON
    TECHNOLOGY FINANCE CORPORATION, as Lender
	 	 
	FROM:	CELSION
    CORPORATION, as Borrower

 

The
undersigned authorized officer (“Officer”) of CELSION CORPORATION, on behalf of itself and all other Borrowers
under and as defined in the Loan Agreement (as defined herein below) (individually and collectively, jointly and severally, “Borrower”),
hereby certifies that in accordance with the terms and conditions of the Venture Loan and Security Agreement dated as of June
__, 2018 by and among Borrower, Collateral Agent, and the Lenders from time to time party thereto (the “Loan Agreement;”
capitalized terms used but not otherwise defined herein shall have the meanings given them in the Loan Agreement),

 

(a)
Borrower is in complete compliance for the period ending _______________ with all required covenants except as noted below;

 

(b)
There are no Events of Default, except as noted below;

 

(c)
Except as noted below, all representations and warranties of Borrower stated in the Loan Documents are true and correct in all
material respects on this date and for the period described in (a), above; provided, however, that such materiality qualifier
shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text
thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true,
accurate and complete in all material respects as of such date.

 

(d)
Borrower, and each of Borrower’s Subsidiaries, has timely filed all required tax returns and reports, Borrower, and each
of Borrower’s Subsidiaries, has timely paid all foreign, federal, state, and local taxes, assessments, deposits and contributions
owed by Borrower, or Subsidiary, except as otherwise permitted pursuant to the terms of Section 5.8 of the Loan Agreement;

 

(e)
No Liens have been levied or claims made against Borrower or any of its Subsidiaries relating to unpaid employee payroll or benefits
of which Borrower has not previously provided written notification to Collateral Agent and the Lender.

 

Attached
are the required documents, if any, supporting our certification(s). The Officer, on behalf of Borrower, further certifies that
the attached financial statements are prepared in accordance with Generally Accepted Accounting Principles (GAAP) and are consistently
applied from one period to the next except as explained in an accompanying letter or footnotes and except, in the case of unaudited
financial statements, for the absence of footnotes and subject to year-end audit adjustments as to the interim financial statements.

 

Please
indicate compliance status since the last Officer’s Certificate by circling Yes, No, or N/A under “Complies”
column.

 

    	 

    	 

    

 

	 	 	Reporting
    Covenant	 	Requirement	 	Actual	 	Complies
	1)	 	Financial
    statements	 	Quarterly
    within 45 days	 	 	 	Yes	No	N/A
	 	 	 	 	 	 	 	 	 	 	 
	2)	 	Annual
    (CPA Audited) statements	 	Within
    180 days after FYE	 	 	 	Yes	No	N/A
	 	 	 	 	 	 	 	 	 	 	 
	3)	 	Annual
    Financial Projections/Budget (prepared on a monthly basis)	 	Annually
    (within 30 days of the earlier of (i) FYE or (ii) BoD approval), and when revised	 	 	 	Yes	No	N/A
	 	 	 	 	 	 	 	 	 	 	 
	4)	 	A/R
    & A/P agings	 	Monthly
    within 30 days	 	 	 	Yes	No	N/A
	 	 	 	 	 	 	 	 	 	 	 
	5)	 	8-K,
    10-K and 10-Q Filings	 	If
    applicable, within 5 days of filing if not on SEC.gov website	 	 	 	Yes	No	N/A
	 	 	 	 	 	 	 	 	 	 	 
	6)	 	Officer’s
    Certificate	 	Quarterly
    within 45 days	 	 	 	Yes	No	N/A
	 	 	 	 	 	 	 	 	 	 	 
	7)	 	IP
    Report	 	When
    required due to new IP filings	 	 	 	Yes	No	N/A
	 	 	 	 	 	 	 	 	 	 	 
	8)	 	Total
    amount of Borrower’s cash and cash equivalents at the last day of the measurement period	 	$___________________	 	 	 	 	 	 
	 	 	 	 	 	 	 	 	 	 	 
	9)	 	Total
    amount of Borrower’s Subsidiaries’ cash and cash equivalents at the last day of the measurement period	 	$___________________	 	 	 	 	 	 

 

Deposit
and Securities Accounts: (Please list all accounts; attach separate sheet if additional space needed)

 

	 	 	Institution
    Name	 	Account
    Number	 	New
    Account?	 	Account
    Control Agreement in place?
	1)	 	 	 	 	 	Yes	No	 	Yes	No
	2)	 	 	 	 	 	Yes	No	 	Yes	No
	3)	 	 	 	 	 	Yes	No	 	Yes	No
	4)	 	 	 	 	 	Yes	No	 	Yes	No

 

    	 

    	 

    

 

Financial
Covenants

 

	 	Covenant	 	Requirement	 	Actual	 	Compliance
	 	Cash
    on deposit in accounts over which Lender maintains an Account Control Agreement	 	$5,000,000	 	[$________]	 	Yes	No

 

Other
Matters

 

If
the response to any of the below is “Yes”, please provide an explanation of the circumstances giving rise to such
“Yes” response on an attachment hereto.

 

	1)	Have
    there been any changes in senior management since the last Officer’s Certificate?	Yes	No
	 	 	 	 
	2)	Has
    there been any transfers/sales/disposals/retirement or relocation of Collateral or IP prohibited by the Loan Agreement?	Yes	No
	 	 	 	 
	3)	Have
    there been any new or pending claims or causes of action against Borrower that involve more than Fifty Thousand Dollars ($50,000.00)?	Yes	No
	 	 	 	 
	4)	Has
    any IP been abandoned, forfeited or dedicated to the public since the last Officer’s Certificate?	Yes	No
	 	 	 	 
	5)	Has
    any Default or Event of Default occurred since the last Officer’s Certificate?	Yes	No
	 	 	 	 
	6)	Has
    Borrower sold new shares of equity or made adjustments to existing shares of equity? If yes, please provide applicable supporting
    documentation.	Yes	No
	 	 	 	 
	7)	Has
    any direct or indirect Subsidiary been formed since the last Officer’s Certificate?	Yes	No
	 	 	 	 
	8)	Has
    any piece of a Borrower’s property been subject to a Lien (other than the lien of Lender pursuant to the Loan Agreement)
    since the date of the last Officer’s Certificate?	Yes	No
	 	 	 	 
	9)	Has
    any Borrower or any Subsidiary incurred any Indebtedness since the date of the last Officer’s Certificate?	Yes	No
	 	 	 	 
	10)	Has
    Borrower or any Subsidiary made any Investment since the date of the last Officer’s Certificate?	Yes	No

 

Exceptions:
Please explain any exceptions with respect to the certification above: (If no exceptions exist, state “No exceptions.”
Attach separate sheet if additional space needed.)

 

CELSION CORPORATION, on behalf of itself and all other Borrowers

 

	By	            	 
	Name:	 	 
	Title:	 	 
	Date:EX-10.5

 Exhibit 10.5 
  

 
 June 28, 2018 
 Adrian
Senderowicz, MD 
 Dear Adrian, 
 You are employed by
Constellation Pharmaceuticals, Inc., a Delaware corporation (the “Company”) pursuant to that certain offer letter, by and between you and the Company dated July 6, 2017 (the “Original Offer Letter”). 

If you accept this letter (the “Amended and Restated Offer Letter”) by signing below, then, effective as of the commencement of trading of the
Company’s common stock on the Nasdaq Stock Market (the “Effective Date”), the following terms shall apply to your continued employment with the Company, which terms shall amend, restate and supersede in their entirety any terms
contained in the Original Offer Letter: 
 Employment: As of the Effective Date, you will continue to be employed to serve on a full-time basis in
the position of Senior Vice President & Chief Medical Officer, reporting to the Chief Executive Officer (“CEO”). You agree to devote your full business time, best efforts, skill, knowledge, attention, and energies to the
advancement of the Company’s business and interests and to the performance of your duties and responsibilities as an employee of the Company. Notwithstanding the foregoing, you may continue to serve as a member of the Board of Directors of Puma
Technologies, Inc. provided that such service does not interfere in any material respect with the performance of your duties for the Company and does not create a conflict of interest. 

Base Salary: As of the Effective Date, your base salary will be at the rate of $15,251.69 per bi-weekly pay
period (which if annualized equals $396,544), less all applicable taxes and withholdings and which will be paid in accordance with the Company’s regular payroll practices, subject to adjustment at the discretion of the Board of Directors of the
Company (the “Board”). 
 Annual Discretionary Bonus: Following the end of each fiscal year, and provided that the Board approves funding
an annual bonus pool for such fiscal year, you will be eligible for a retention and performance bonus (the “Performance Bonus”). The target amount of such Performance Bonus will be 40% of your annualized base salary for the applicable
fiscal year, based on the Company’s achievement of its performance goals and your achievement of your performance goals for the fiscal year. The Board or its designee, in its sole discretion, shall determine whether goals have been achieved and
whether a Performance Bonus will be awarded. Any Performance Bonus will be paid to you following the close of the fiscal year to which it relates (but in no event later than March 15th). In any
event, you must be an active employee of the Company on the date any Performance Bonus is distributed in order to be eligible for and to earn a bonus award, as it also serves as an incentive to remain employed by the Company. 

Sign on Bonus: In connection with the commencement of your employment under the Original Offer Letter, you received a
one-time sign-on bonus in the amount of $50,000.00, less all applicable taxes and withholdings. Please note that if, prior to the
one-year anniversary of July 10, 2017 (the “start date”), you resign your employment without Good Reason (as defined below) or your employment is terminated for Cause (as defined below), you
will be required to repay the Company (within thirty (30) days following your separation date) an amount equal to $4,166.66 per complete calendar month remaining between your separation date and the
one-year anniversary of the start date. 
  
 

 

 Withholdings: All compensation payable to you shall be subject to applicable taxes and withholdings. 

Initial Stock Option Grant: In connection with the commencement of your employment, you were granted an option to purchase
1,600,000 shares of the Company’s common stock (the “Initial Option”), at a price equal to the fair market value of the common stock on the date of the grant, as determined by the Board. This Initial Option is subject to
the standard terms and conditions of the Constellation Pharmaceuticals Stock Option Plan and the stock option agreement provided in connection therewith. As set forth in the stock option agreement, the Initial Option vests over four years at
the rate of 25% after twelve months of active employment beginning with the start date and an additional 6.25% per quarter in accordance with the specific terms provided in the stock option agreement. 

Subsequent Stock Option Grant: You have been granted an option to purchase up to an additional 800,000 shares of the Company’s common stock (the
“Subsequent Grant”), at a price equal to the fair market value of the common stock on the date of the grant, as determined by the Board. This Subsequent Grant is subject to the standard terms and conditions of the Constellation
Pharmaceuticals Stock Option Plan and the stock option agreement provided in connection therewith. Pursuant to this Amended and Restated Offer Letter and an amendment to the applicable stock option agreement, as of the Effective Date, 100,000
of the shares subject to the option will continue to vest at the rate of 6.25% per quarter with a vesting start date of July 10, 2017 and the remaining 700,000 of the shares subject to the option will vest over four years, from the Effective
Date, at the rate of 6.25% per quarter, each subject to your continued employment with the Company. 
 Benefits: You may participate in any and all
benefit programs that the Company establishes and makes available to its employees from time to time, provided that you are eligible under (and subject to all provisions of) the plan documents governing those programs, including the Company’s
401(k) plan, which is currently being offered through Fidelity Investments. We have provided you with a summary of the benefits that are currently provided to the employees of Constellation Pharmaceuticals. Please note that the benefits made
available by the Company, and the rules, terms, and conditions for participation in such benefit plans, may be changed by the Company at any time, and from time to time without advance notice. 

Change In Control: The Company has adopted a Change in Control Severance Plan (the “Plan”), in which you are eligible to
participate and that has been provided to you under separate cover. The Plan is the sole agreement between the Company and you governing any compensation and/or benefits, equity or otherwise, that you may be eligible to receive if your employment
with the Company (or its successor in a “Change in Control” (as defined in the Plan) is terminated other than for “Cause” (as defined in the Plan) or terminates for “Good Reason” (as defined in the Plan) during the
Protected Period (as defined in the Plan), but not in the event of death or disability. In the event there is a conflict between the terms of this Amended and Restated Offer Letter and the terms of the Plan, the terms of the Plan shall govern. For
the avoidance of doubt, if you are eligible for benefits under the Plan, you will not be eligible to receive the Severance Benefits (as defined below) or the Additional Severance Benefit (as defined below). The vesting under the Plan will apply to
both the Initial Option and the Subsequent Grant. 

 Employment At-Will: This Amended and Restated Offer Letter is not
intended to create or constitute an employment agreement or contract between you and Constellation for any definite period of time and shall not be construed as an agreement, either express or implied, to employ you for any stated term. If you
accept the Company’s offer of continued employment on the terms set forth herein, your employment with the Company will continue to be on an “at-will” basis, meaning that both the Company and
you remain free to end the employment relationship for any reason, at any time, with or without cause or notice. Although your job duties, title, compensation and benefits, as well as the Company’s personnel policies and procedures, may
change from time to time, the “at-will” nature of your employment may only be changed by a written agreement signed by you and the CEO that expressly states the intention to modify the at-will nature of your employment. Similarly, nothing in this Amended and Restated Offer Letter shall be construed as an agreement, either express or implied, to pay you any compensation or grant you any benefit
beyond the end of your employment with the Company, except as otherwise explicitly set forth herein. 
 Severance Benefits Not in Connection
With a Change in Control:
 Without limiting the at-will nature of your employment with the
Company, in the event that, outside of the Protected Period (as defined in the Plan), Constellation terminates your employment without Cause (as defined below) or you resign your employment for Good Reason (as defined below), and subject to the
Severance Conditions set forth below, Constellation shall: (i) pay you in one lump sum a severance payment equivalent to (x) twelve (12) months of your then current base salary which amount shall, if your separation occurs prior to
the one-year anniversary of your start date, be multiplied by (y) a fraction the numerator of which is the number of days from the start date through and including the date employment ends and the
denominator of which is 365, less all applicable taxes and withholdings (the “Severance Pay”); and (ii) if you are eligible for and timely elect to continue receiving group medical and/or dental insurance under COBRA, until the
earlier of (x) the date that is twelve (12) months following your separation date, and (y) the date on which you obtain alternative coverage (as applicable, the “COBRA Contribution Period”), continue to pay the share of the
premiums for such coverage to the same extent it was paying such premiums on your behalf immediately prior to your separation date (though if, as a result of a change in legal requirements, the Company’s provision of payments for COBRA will
violate the nondiscrimination requirements of applicable law, this COBRA benefit will not apply) (collectively, the “Severance Benefits”). In addition, if (a) a new CEO commences employment with the Company prior to the one-year anniversary of your start date, and (b) the Company terminates your employment without Cause prior to the one-year anniversary of your start date and
(c) the date of such termination occurs outside of the Protected Period (as defined in the Plan), then, subject to the Severance Conditions, instead (and in lieu) of the prorated Severance Pay set forth in clause (i) above, you will
receive a lump sum severance payment equal to twelve (12) months of your then current base salary, and the Initial Option and the Subsequent Grant shall vest and become immediately exercisable based on 2.0833% of the number of shares under the
Initial Option and the Subsequent Grant times the number of full calendar months elapsed since the start date as of the date of termination (together, the “Additional Severance Benefit”) and any remaining portions of the Initial Option and
the Subsequent Grant will immediately expire. 
 The Company’s obligation to provide you with the Severance Benefits and/or the Additional Severance
Benefit is contingent upon your entering into a Severance and Release of Claims Agreement (the “Severance Agreement”) in a form to be provided by the Company (which will include, at a minimum, a release of all releasable claims you may
have and your agreement to non-disparagement, confidentiality, and cooperation obligations). The Severance Agreement must be signed by you, and any applicable revocation period with respect thereto must have
expired, by the 

 
60th day following the end of your employment (or such shorter period as the Company may specify). Payment of the Severance Pay will be made
on the first regular payday after the Severance Agreement becomes effective; provided, however, that if the 60th day following your separation date occurs in the calendar year following the
year of your separation, then payment shall not be made before January 1 of such subsequent calendar year. 
 Cause: For purposes of this Amended and
Restated Offer Letter, “Cause” shall mean (i) a material breach of any material term of any applicable offer letter or agreement between you and the Company, including the Employee
Non-Competition, Non-Solicitation, Confidentiality and Assignment Agreement referred to below, (ii) your plea of guilty or nolo contendere to, or your conviction
of, a felony offense or a crime of dishonesty, (iii) your repeated unexplained or unjustified absences, refusals or failures to carry out the lawful directions of the Board or the CEO, or (iv) your willful misconduct that results or is
reasonably likely to result in material harm to the Company. 
 Good Reason: For purposes of this Amended and Restated Offer Letter, “Good
Reason” shall mean (i) a material reduction of your base salary, (ii) a material diminution of your authority, duties, or responsibilities, (iii) a requirement that your principal place of providing services to the Company change
by more than 50 miles, other than in a direction that reduces your daily commuting distance; or (iv) any material breach by the Company of a material provision of any agreement between you and the Company under which you provide services.
Notwithstanding the occurrence of any of the foregoing events or circumstances, a resignation shall not be deemed to constitute resignation for Good Reason unless (x) you give the Company a written notice of the purported Good Reason (no more
than 90 days after the initial existence of such event or circumstance), (y) such event or circumstance has not been fully corrected (and you have not been reasonably compensated for any losses or damages resulting therefrom) within 30 days
following the Company’s receipt of such notice, and (z) if the Company does not correct, you end your employment not more than 30 days following the period to correct in (y). 

Payments Subject to Section 409A: This Amended and Restated Offer Letter, and any payments or other benefits under this Amended and
Restated Offer Letter, is intended to comply, to the extent applicable, with the provisions of Section 409A of the Internal Revenue Code of 1986, as amended (“Section 409A”) and shall, to the extent practicable, be construed in
accordance with such section and consistent with Exhibit A to this Amended and Restated Offer Letter. 
 Employment Eligibility: You
hereby acknowledge that your continued employment with the Company is conditioned upon your continued compliance with the Employee Non-Competition, Non-Solicitation,
Confidentiality and Assignment Agreement that you previously signed as a condition of your employment with the Company, which agreement remains in full force and effect, and which you hereby reaffirm. 

Company Policies and Procedures: As an employee of the Company, you will be required to comply with all Company policies and procedures. Violations of
the Company’s policies may lead to immediate termination of your employment. Further, the Company’s premises, including all workspaces, furniture, documents, and other tangible materials, and all information technology resources of the
Company (including computers, data and other electronic files, and all internet and email) are subject to oversight and inspection by the Company at any time. Company employees should have no expectation of privacy with regard to any Company
premises, materials, resources, or information. 

 Miscellaneous: You represent that you are not bound by any employment contract, restrictive covenant or
other restriction preventing you from continuing employment with or carrying out your responsibilities for the Company, or which is in any way inconsistent with the terms of this Amended and Restated Offer Letter. 

Please note that this Amended and Restated Offer Letter is your formal offer of continued employment and supersedes any and all prior or contemporaneous
agreements, discussions and understandings, whether written or oral, relating to the subject matter of this Amended and Restated Offer Letter or your employment with the Company, including without limitation the Original Offer Letter. The resolution
of any disputes under this Amended and Restated Offer Letter will be governed by Massachusetts law. 
 If you agree with the provisions of this Amended and
Restated Offer Letter, please sign the enclosed duplicate of this Amended and Restated Offer Letter in the space provided below and return it to Brenda Sousa no later than July 5, 2018. 

Sincerely, 
  

	
	 /s/ Jigar
Raythatha                                        

	 Jigar Raythatha

	 President & CEO

	Constellation Pharmaceuticals, Inc.

 The foregoing correctly sets forth the terms of my at-will employment with
Constellation Pharmaceuticals, Inc. I am not relying on any representations other than those set forth above. 
  

			
	 /s/ Adrian
Senderowicz                                
	  	7/2/18        
	Adrian Senderowicz, MD	  	Date

 Exhibit A 

Payments Subject to Section 409A 
 The
following rules shall apply with respect to distribution of the payments and benefits, if any, to be provided under this offer letter: 
  

	 	(a)	 It is intended that each installment of the severance payments and benefits provided under this offer letter
shall be treated as a separate “payment” for purposes of Section 409A of the Internal Revenue Code and the guidance issued thereunder (“Section 409A”). Neither you nor Constellation shall have the right to accelerate or
defer the delivery of any such payments or benefits except to the extent specifically permitted or required by Section 409A. 

  

	 	(b)	 If, as of the date of your “separation from service” from Constellation, you are not a
“specified employee” (within the meaning of Section 409A), then each installment of the severance payments and benefits shall be made on the dates and terms set forth in this offer letter. 

 

	 	(c)	 If, as of the date of your “separation from service” from Constellation, you are a “specified
employee” (within the meaning of Section 409A), then: 

  

	 	(i)	 Each installment of the severance payments and benefits due under this offer letter that is paid within the
short-term deferral period (as defined under Section 409A) shall be treated as a short-term deferral within the meaning of Treasury Regulation Section 1.409A-1(b)(4) to the maximum extent permissible
under Section 409A and shall be made on the dates and terms set forth in this offer letter; and 

  

	 	(ii)	 Each installment of the severance and benefits due under this offer letter that is not described in paragraph
(i) above and that would, absent this subsection, be paid within the six-month period following your “separation from service” from Constellation shall not be paid until the date that is six
months and one day after such separation from service, (or, if earlier, upon your death), with any such installments that are required to be delayed being accumulated during the six-month period and paid in a
lump sum on the date that is six months and one day following your separation from service and any subsequent installments, if any, being paid in accordance with the dates and terms set forth herein; provided, however, that the preceding provisions
of this sentence shall not apply to any installment of severance payments and benefits if any to the maximum extent that such installment is deemed to be paid under a separation pay plan that does not provide for a deferral of compensation by reason
of the application of Treasury Regulation Section 1.409A-1(b)(iii) (relating to separation pay upon an involuntary “separation from service”. Any installments that qualify for the exception
under Treasury Regulation Section 1.409A-1(b)(9)(iii) must be paid no later than the last day of your second taxable year following the taxable year in which separation from service occurs.

	 	(d)	 The determination of whether and when your separation from service from Constellation has occurred shall be
made and in a manner consistent with, and based on the presumptions set forth in, Treasury Regulation Section 1.409A-1(h). Solely for purposes of this paragraph (d), “Constellation” shall
include all persons with whom Constellation would be considered a single employer under Sections 414(b) and 414(c) of the Code. 

  

	 	(e)	 All reimbursements and in-kind benefits provided under this offer
letter shall be made or provided in accordance with the requirements of Section 409A to the extent that such reimbursements or in-kind benefits are subject to Section 409A, including, where
applicable the requirement that (i) any reimbursement is for expenses incurred during your lifetime (or during a shorter period of time specified in this offer letter), (ii) the amount of expenses eligible for reimbursement during a calendar
year may not affect the expenses eligible for reimbursement in any other calendar year, (iii) the reimbursement of an eligible expense will be made on or before the last day of the calendar year following the year in which the expense is
incurred and (iv) the right to reimbursement is not subject to set off or liquidation or exchange for any other benefit. 

  

	 	(f)	 Notwithstanding anything to the contrary in this offer letter, any payment or benefit under this offer letter
or otherwise that may be exempt from Section 409A pursuant to Treasury Regulation Section 1.409A-1(b)(9)(v)(A) or (C) (relating to certain reimbursements and
in-kind benefits) shall be paid or provided to you only to the extent that the expenses are not incurred, or the benefits are not provided, beyond the last day of the second calendar year following the
calendar year in which your “separation from service” occurs; and provided further that such expenses are reimbursed no later than the last day of the third calendar year following the calendar year in which your “separation from
service” occurs.

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