Document:

Employment Agreement

 Exhibit 10.1 

EMPLOYMENT AGREEMENT 

This EMPLOYMENT AGREEMENT (the “Agreement”) is entered into effective as of September 7, 2010 (the
“Effective Date”) by and between Benny Ward (“Employee”) and BioDelivery Sciences International, Inc. (the “Company”). 

WHEREAS, the Company desires to retain the services of Employee as the Company’s Executive Vice President of Business and
Strategic Development, and the Employee desires to serve in such capacity; and 
 WHEREAS, in light of the foregoing, the
Company and Employee desire to memorilaze their employment relationship on the terms, conditions and covenants set forth in this Agreement. 

NOW, THEREFORE, in consideration of the foregoing, the mutual covenants contained herein and other good and valuable
consideration, receipt of which Employee and the Company hereby acknowledge, Employee and the Company agree, as follows: 
 1.
Position. Effective as of the Effective Date, Employee agrees to be employed by the Company in the position of Executive Vice President of Business and Strategic Development. Employee agrees to perform the job duties and to carry out the
responsibilities of that position, as reasonably determined by the President and Chief Executive Officer of the Company (the “CEO”) from time to time or the Board of Directors of the Company (the “Board of
Directors”). Employee shall report to the CEO or such other executive officer of the Company as may be designated by the Board of Directors. 

2. Employee’s Effort and Duties. Employee shall perform his duties in the capacity as an employee and in such capacity shall
spend his full working time and best efforts, skill and attention to his position and to the business and interests of the Company. Subject to the oversight and direction of the CEO, Employee shall be primarily responsible for: (i) generally
assisting and providing input and guidance on the creation and implementation of all of the Company’s strategic initiatives; (ii) working with the CEO and the Company’s Chief Financial Officer (the “CFO”) in
coordinating the Company’s financing strategy and taking a lead role in implementing the Company’s financing activities; (iii) taking a lead role in strucuturing and negotiating, either individually or through subordinates and working
with the CEO and CFO, all business transactions, including in-and out-licensing, commercial partnerships and supply relationships; (iv) providing strategic and financial input into all of the Company’s business transactions;
(v) developing strong relationships with institutional fund managers, investment bankers and analysts that focus on the specialty pharmaceutical sector; (vi) developing the Company’s institutional shareholder base; and
(vii) overseeing investor relations activities. 

 3. Base Salary; Bonus; Benefits. 

(a) Base Salary. The Company shall pay Employee compensation for services rendered in the amount of no less than One Hundred
Ninety-Five Thousand ($195,000.00) per annum (the “Base Salary”), payable on a bi-weekly basis or otherwise in accordance with the Company’s standard policies. Employee’s Base Salary may be subject to annual increases as
determined by the CEO or the Board of Directors or a designated committee thereof in its sole discretion and may be subject to decrease only if such decrease is a proportional part of an across the board base salary decrease affecting all of the
Company’s officers. 
 (b) Optional Bonus. Employee shall also be elligible to receive a cash bonus of up to 40% of
the Base Salary for each Company fiscal year, which bonus shall be granted in the sole and absolute discretion of the CEO or the Board of Directors or a designated committee thereof. 

(c) Options. As of the Effective Date, Employee will be granted incentive stock options to purchase 85,000
shares of Common Stock (the “Options”). The strike price of the Options will be the 30-day volume-weighted average share price of the Company’s publicly-traded common stock as of the Effective Date. The Options will vest
(assuming the Employee is still employed by the Company) annually in
 1/3 increments over 3 years (28,000 Options in
years one and two and 29,000 Options in year 3), beginning on the Effective Date. The grant of the Options will be further memorilalzed by the Company’s standard option agreement which the Employee shall execute. 

(d) Other Compensation and Benefits. In addition, Employee shall receive such additional compensation or other benefits as are
provided to Company employees generally and similarly-situated Company employees specifically (including, without limitation, three (3) weeks paid vacation and days off administered in accordance with prevailing Company policy and additional
participation in the Company’s stock incentive plans), in each case as may be determined in the sole and absolute discretion of the Board of Directors or a designated committee thereof. 

4. Term; Termination. Unless earlier terminated under this Section 4, this Agreement and the status and obligations of
Employee thereunder as an employee of the Company (except as provided for below) shall be effective for a period ending on the first anniversary of the Effective Date (the “Initial Term”) and, after the expiration of the Initial
Term, this Agreement shall automatically renew for successive one (1) year terms (each a “Renewal Term” and, collectively with all Renewal Terms and the Initial Term, the “Term”) unless, following the Initial
Term, either party gives thirty (30) days’ advance written notice of its intention not to renew this Agreement at the conclusion of the next Renewal Term. Termination of this Agreement shall not, in any event, affect any rights that
Employee may have been specifically granted to Employee by the Board of Directors or a designated committee thereof pursuant to any of the Company’s retirement plans, supplementary retirement plans, profit sharing and savings plans, healthcare,
401(k) any other employee benefit plans sponsored by the Company, it being understood that no such rights are granted hereunder. In addition, notwithstanding the expiry or termination of this Agreement pursuant to this Section 4 or

  

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otherwise, Employee’s rights and obligations under Sections 5 through 14 inclusive of this Agreement shall survive the termination or expiration of this Agreement in accordance with the
terms of such Sections. It is agreed that a condition to the payment of any severence amount or post-termination benefit called for under this Agreement or otherwise shall be: (i) the Company’s concurrent receipt of a general release of
all claims against the Company and its affiliates by Employee in the form reasonably acceptable to the Company and Employee and (ii) that all such payments shall comply with Section 409A of the Internal Revenue Code of 1986, as amended,
and all regulations prmulgated thereunder. 
 (a) Death or Disability. This Agreement shall automatically terminate upon
the death or Disability of Employee and, thereafter all of his rights hereunder, including the rights to receive compensation and benefits, except as otherwise required by law, shall terminate; provided that, upon termination of this Agreement as a
result the death or Disability of Employee, Employee or his estate shall be entitled to a one-time pro rata share (through the termination date) of any target bonus for the fiscal year in which such termination occurred (the “Pro Rated
Bonus”). As used herein, the term “Disability” means the physical or mental illness or incapacity (including, without limitation, as a result of abuse of alcohol or other drugs or controlled substances) of Employee which
results in the Employee being unable to substantially perform the duties and services required to be performed under this Agreement for a period of: (i) one hundred twenty (120) consecutive days or longer or (ii) one hundred eighty
(180) days in any three hundred sixty (360) consecutive day period. 
 (b) Termination with Notice by Either
Party. The Company or Employee may terminate this Agreement for any reason or no reason upon thirty (30) days prior written notice to the other. In case of termination by the Company only under this paragraph: (i) if the Company’s
notice of termination is given prior to or as of the conclusion of the Initial Term, the Company shall pay Employee a one-time cash severance payment equal to 50% of the full year’s Base Salary plus the Employee’s Pro Rated Bonus
and (ii) if the Company’s notice of termination is given after the conclusion of the Initial Term, the Company shall pay Employee a one-time cash severance payment equal to the full year’s Base Salary plus the Employee’s
Pro Rated Bonus. The Company shall have no further obligations to Employee following termination. 
 (c) Termination for Good
Cause. As used herein “Good Cause” shall mean any one or more of the following as determined in the reasonable discretion of the Company: 

(1) a continuing material breach or material default (including, without limitation, any material deriliction of duty) by Employee of
the terms of this Agreement, or any related agreement which is an Exhibit hereto, except for any such breach or default which is caused by the physical disability of Employee (as determined by a neutral physician), or a continuing failure by
Employee to follow the direction of the CEO or the Board of Directors; 
 (2) gross negligence, willful misfeasance or breach
of fiduciary duty by Employee; 
 (3) the commission by Employee of an act of fraud, embezzlement or any felony or other crime
of dishonesty in connection with Employee’s duties; or 
  

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 (4) conviction of Employee of a felony or any other crime that would
materially and adversely affect: (i) the business reputation of the Company or (ii) the performance of the Employee’s duties hereunder. 

In the event of a termination by the Company for Good Cause, the Company will pay the Employee the Base Salary earned and expenses
reimbursable under this Agreement incurred through the date of the Employee’s termination, and shall have no further responsibility for termination or other payments to Employee. 

(d) Termination Upon a Change of Control. In the event that Agreement or Employee’s employment with the Company is terminated
by the Company or its successor within six (6) months following the occurrence of a “Change of Control” (as defined below) of the Company (each, a “Severence Triggering Event”), then: (A) the Company shall pay
Employee a one-time cash severance payment equal to: (1) his then current annual Base Salary plus an amount equal to fifty percent (50%) of his then current annual Base Salary multiplied by (B) 1.5, (2) Employee
shall maintain any rights that Employee may have been specifically granted to Employee pursuant to any of the Company’s or its successor’s retirement plans, supplementary retirement plans, profit sharing and savings plans, healthcare,
401(k) and any other employee benefit plans sponsored by the Company and (iii) all unvested options to acquire shares of Company common stock granted to Employee under the Company’s Amended and Restated 2001 Incentive Plan or any similar
plan shall immediately become fully vested and shall be exerciseable over a period of three (3) years from the occurrence of a Severence Triggering Event. Following the payment of severance, the Company or its successor shall have no further
obligations to Employee following termination. 
 For purposes of this Agreement, the term “Change of Control”
means the occurrence of any one or more of the following events (it being agreed that, with respect to paragraphs (i) and (iii) of this definition below, a “Change of Control” shall not be deemed to have occurred if the
applicable third party acquiring party is an “affiliate” of the Company within the meaning of Rule 405 promulgated under the Securities Act of 1933, as amended): 

(i) An acquisition (whether directly from the Company or otherwise) of any voting securities of the Company (the “Voting
Securities”) by any “Person” (as the term person is used for purposes of Section 13(d) or 14(d) of the Securities and Exchange Act of 1934, as amended (the “1934 Act”)), immediately after which such Person
has “Beneficial Ownership” (within the meaning of Rule 13d-3 promulgated under the 1934 Act) of forty percent (40%) or more of the combined voting power of the Company’s then outstanding Voting Securities. 

(ii) The individuals who, as of the date hereof, are members of the Company’s Board of Directors cease, by reason of a financing,
merger, combination, acquisition, takeover or other non-ordinary course transaction affecting the Company, to constitute at least fifty-one percent (51%) of the members of the Board of Directors; or 

 

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 (iii) Approval by the Board of Directors and, if required, stockholders of the Company of ,
or execution by the Company of any definitive agreement with respect to, or the consummation of (it being understood that the mere execution of a term sheet, memorandum of understanding or other non-binding document shall not constitute a Change of
Control): 
 (A) A merger, consolidation or reorganization involving the Company, where either or both of the events described
in clauses (i) or (ii) above would be the result; 
 (B) A liquidation or dissolution of or appointment of a
receiver, rehabilitator, conservator or similar person for, or the filing by a third party of an involuntary bankruptcy against, the Company; or 

(C) An agreement for the sale or other disposition of all or substantially all of the assets of the Company to any Person (other than a
transfer to a subsidiary of the Company). 
 5. Confidentiality. Employee shall keep confidential, except as the Company
may otherwise consent in writing, and not disclose or make any use of except for the benefit of the Company, at any time during the term of this Agreement and for a period of five (5) years thereafter, any trade secrets, knowledge, data or
other confidential, secret or proprietary information of the Company relating to inventions, products, processes, knowledge, know how, technical or other data, designs, formulas, test data, customer lists, business plans, marketing or manufacturing
plans and strategies, and product pricing strategies or other subject matter pertaining to any business of the Company or any of its clients, customers, consultants, licensees, subsidiairies or affiliates which Employee may produce, obtain or
otherwise learn of during the course of Employee’s performance of services and after its termination (collectively “Confidential Information”), provided that the term “Confidential Information” shall not include
information, technical data or know-how that is or becomes part of the public domain not as a result of any inaction or action of the Employee. Employee shall not deliver, reproduce, or in any way allow any such Confidential Information to be
delivered to or used by any third parties without the specific direction or consent of a duly authorized representative of the Company. The terms of this paragraph shall survive termination of this Agreement. In addition, Employee agrees to execute
the Company’s standard Confidentiality and Intellectual Property Agreement attached as Exhibit A hereto (the “Confidentiality Agreement”). 

6. Return of Confidential Material. Upon the completion or other termination of Employee’s services for the Company, Employee
shall promptly surrender and deliver to the Company all records, materials, equipment, drawings, documents, lab notes and books and data of any nature (electronic or otherwise) describing, including or pertaining to any Confidential Information, and
Employee will not take with him any description containing or pertaining to any Confidential Information which Employee may produce or obtain during the course of his services. The terms of this paragraph shall survive termination of this Agreement.

 7. Assignment and Disclosure of Inventions. Employee shall assign and transfer to the Company his entire right, title
and interest in and to all Inventions (as defined in the Confidentiality Agreement) and disclose to the Company all Inventions in accordance with the terms set forth in the Confidentiality Agreement. The terms of this paragraph shall survive
termination of this Agreement. 
  

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 8. Execution of Documents. During the term of this Agreement and thereafter, Employee
will execute, acknowledge and deliver to the Company or its nominee upon request and at its expense all such documents, including applications for patents and copyrights and assignments of inventions, patents and copyrights to be issued therefore,
as the Company may reasonably determine necessary or desirable to apply for and obtain letters, patents, and copyrights on Inventions in any and all countries and/or to protect the interest of the Company or its nominee in Inventions, patents and
copyrights and to vest title thereto in the Company or its nominee. The terms of this paragraph shall survive termination of this Agreement. 

9. Maintenance of Records. Employee will keep and maintain adequate and current written records of all Inventions made or
conceived by Employee (in the form of notes, sketches, drawings and as may be specified by the Company), and shall deliver such records promptly to the Company at the Company’s request, whether made solely by Employee or jointly with others,
which records shall be available to and remain the sole property of the Company at all times. 
 10. Prior Inventions. It
is understood that all Inventions, if any, patented or unpatented, which Employee made prior to the date that the Company and Employee entered into this Agreement, are excluded from the scope of this Agreement. To preclude any possible uncertainty,
Employee has set forth on Exhibit A to the Confidentiality Agreement a complete list of all such prior inventions, including numbers of all patents and patent applications, and a brief description of all unpatented inventions which are not
the property of another party (including, without limitation a current or previous contracting party). If no items are included on Exhibit A to the Confidentiality Agreement, Employee has no such prior inventions. Employee will notify the
Company in writing before Employee makes any disclosure or performs any work on behalf of the Company which appears to threaten or conflict with proprietary rights Employee claims in any such invention or idea. In the event of Employee’s
failure to give such notice, Employee will make no claim against the Company with respect to any such inventions or ideas. The terms of this paragraph shall survive termination of this Agreement. 

11. Competition. Employee will not do, or intend to do, any of the following, either directly or indirectly, during the Term and
during the period of two (2) years after Employee’s cessation of employment with the Company, anywhere in the world (it being agreed that if this Agreement is terminated upon the occurrence of a Severence Triggering Event as provided for
in Section 4(e) hereof only, the duration of the Employee’s non-competition covenant shall be eighteen (18) months and not two (2) years). In the event that a court of competent jurisdiction determines that Employee improperly
competes with the Company in violation of this Section 11, the period during which he engages in such competition shall not be counted in determining the duration of the two (2) year non-compete restriction: 

(a) For purposes of this Agreement, “Competitive Activity” shall mean the development, manufacture, sale, license,
packaging or marketing of the following technologies (or products incorporating such technologies): (i) drug, nutraceuticals, genes, vaccines, vitamin 

 

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or other compound delivery technologies involving liposomes, proteoliposomes, cochleates, buccal, transmucosal, transdermal, oral or other applications and/or derivatives thereof and
(ii) any technology or product which Employee was actively and directly participating in on behalf of the Company or any subsidiary of the Company or joint venture in which the Company is participating at the time of cessation of
Employee’s employment with the Company. 
 (b) Employee agrees that, during the time frames described herein, he shall not,
directly or indirectly, own, manage, operate, control, consult for, be an officer or director of, work for, or be employed in any capacity by any company, eleemosynary institution or any other business, entity, agency or organization (or a discrete
business unit within any such entity) whose primary business purpose is to engage in a Competitive Activity; provided, however, that Employee may serve as a director, consultant or scientific advisor of such an entity that is either a Company
licensee, or, for non-licensees, in such capacity as the Board of Directors has granted him written permission, such permission not to be unreasonably withheld. 

(c) Employee agrees that, during the time frames described herein, he shall not solicit or perform services in connection with any
Competitive Activity for any customers, partners, licensors or licensees of the Company or any entities with which the Company has undertaken joint ventures, joint studies or developmental activities (in each case, whether now existing or existing
at the time of Employee’s cessation of employment with the Company. 
 (d) Employee and Company agree that the phrase
“Employee’s cessation of employment with the Company” as used in this Agreement, refers to any separation from his employment at the Company either voluntarily or involuntarily, either with cause or without cause, or whether the
separation is at the behest of the Company or Employee. Nothing in this Agreement shall preclude him from employment at a not-for-profit or governmental institution, provided that no for-profit business involved in drug delivery directly or
indirectly derives a benefit from Employee’s employment. 
 12. Non-Solicitation. Employee agrees that Employee will
not, without the prior written consent of the Company, at any time during the Term and during the period of two (2) years after Employee’s cessation of employment with the Company for whatever reason, either individually or through any
entity controlled by Employee, and either on Employee’s behalf or on behalf of any other person or entity (including, without limitation, those competing or endeavoring to compete with the Company), directly or indirectly, knowingly solicit for
employment or retention (or, following such solicitation, employ or retain) as an employee, independent contractor or agent, any person who is an employee of the Company as of the date of the cessastion or termination of Employee’s employment
with the Company or was an employee of the Company at any time during the two (2) year prior to the the cessastion or termination of Employee’s employment with the Company. Employee further agrees that, should Employee be approached by a
person who Employee has actual knowledge was an employee of the Company or any subsidiary or joint venture thereof during the period while Employee was employed by the Company, Employee will not offer to nor employ or retain (or refer to a third
party) as an employee, independent contractor or agent any such person for a period of two (2) years following the cessastion of Employee’s employment with the Company. 

 

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 13. Other Obligations. 

(a) Employee acknowledges that the Company from time to time may have agreements with other persons or with the U.S. Government, or
agencies thereof, which impose obligations or restrictions on the Company regarding inventions made during the course of work thereunder or regarding the confidential nature of such work. Employee will be bound by all such obligations and
restrictions and will take all action necessary to discharge the obligations of the Company thereunder. 
 (b) Employee
acknowledges that all of Employee’s obligations under this Agreement (but not including the restrictive covenants contained herein) shall be subject to any applicable agreements with, and policies issued by the Company to which Employee and all
other similarly-situated employees are subject. 
 14. Trade Secrets of Others. Employee represents that his performance
of all the terms of this Agreement as employee to the Company does not and will not breach any agreement to keep in confidence proprietary information, knowledge or data acquired by Employee in confidence or in trust, and Employee will not disclose
to the Company, or allow the Company to use, any confidential or proprietary information or material belonging to any other person or entity. Employee will not enter into any agreement, either written or oral, which is in conflict with this
Agreement. 
 15. Injunctive Relief. Employee acknowledges that any breach or attempted breach by Employee of paragraphs
5 through 14 of this Agreement shall cause the Company irreparable harm for which any adequate monetary remedy does not exist. Accordingly, in the event of any such breach or threatened breach, the Company shall be entitled to obtain injunctive
relief, without the necessity of posting a bond or other surety restraining such breach or threatened breach and without the requirement of proving actual damages. 

16. Reasonable Terms. Employee acknowledges and agrees that the restrictive covenants contained in this Agreement have been
reviewed by Employee with the benefit of counsel and that such covenants are reasonable in all of the circumstances for the protection of the legitimate interests of the Company. 

17. Modification. This Agreement may not be changed, modified, released, discharged, abandoned, or otherwise amended, in whole or
in part, except by an instrument in writing, signed by Employee and by the Company. Any subsequent change or changes in Employee’s relationship with the Company or Employee’s compensation shall not affect the validity or scope of this
Agreement. 
 18. Entire Agreement. Employee acknowledges receipt of this Agreement, and agrees that with respect to the
subject matter thereof, it is Employee’s entire agreement with the Company, superseding any previous oral or written communications, representations, understandings with the Company or any office or representative thereof. Each party to the
Agreement acknowledges that, in executing this Agreement, such party has had the opportunity to seek the advice of independent legal counsel, and has read and understood all of the terms and provisions of the Agreement. 

 

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 19. Severability. In the event that any paragraph or provision of this Agreement
shall be held to be illegal or unenforceable, the entire Agreement shall not fail on account thereof. It is further agreed that if any one or more of such paragraphs or provisions shall be judged to be void as going beyond what is reasonable in all
of the circumstances for the protection of the interests of the Company, but would be valid if part of the wording thereof were deleted or the period thereof reduced or the range of activities covered thereby reduced in scope, the said reduction
shall be deemed to apply with such modifications as may be necessary to make them valid and effective and any such modification shall not thereby affect the validity of any other paragraph or provisions contained in this Agreement. 

20. Successors and Assigns. This Agreement shall be binding upon Employee’s heirs, executors, administrators or other legal
representatives and is for the benefit of the Company, its successors and assigns. 
 21. Governing Law. This Agreement
shall be governed by the laws of the State of Delaware except for any conflicts of law rules thereof that might direct the application of the substantive law of another state. 

22. Counterparts. This Agreement may be signed in counterparts and delivered by facsimile or other electronic transmission, and
each such counterpart shall be deemed an original and all of which shall together constitute one agreement. 
 23.
Arbitration. Except as provided for in Section 15 hereof, in the event that the Company or Employee, his spouse or any other person claiming benefits on behalf of or through Employee, has a dispute or claim based upon this Agreement
including the interpretation or application of the terms and provisions of this Agreement, the sole and exclusive remedy is for that party to submit the dispute to binding arbitration in accordance with the rules of arbitration of the American
Arbitration Association (“AAA”) in Raleigh, North Carolina. Any arbitrator selected to arbitrate any such dispute shall be independent and neutral and will have the power to interpret this Agreement. Any determination or decision by
the arbitrator shall be binding upon the parties and may be enforced in any court of law. The expenses of the arbitrator will be paid 50% by the Company and 50% by Employee, his spouse or other person, as the case may be, provided that the
arbitrator shall be free to apportion such fees between the parties as he/she may determine in their discretion as permitted by the AAA rules of arbitration. The parties agree that this arbitration provision does not apply to the right of Employee
to file a charge, testify, assist or participate in any manner in an investigation, hearing or proceeding before the Equal Employment Opportunity Commission or any other agency pertaining to any matters covered by this Agreement and within the
jurisdiction of the agency. 
 24. No Waiver. No waiver by the Company of any breach of this Agreement by Employee shall
constitute a waiver of any subsequent breach. 
  

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 25. Notice. Any notice hereby required or permitted to be given shall be sufficiently
given if in writing and upon mailing by registered or certified mail, postage prepaid, to either party at the address of such party or such othis address as shall have been designated by written notice by such party to the other party. 

26. Taxes. The Company may withhold from any payments made under this Agreement (including severance payments) all applicable
taxes, including but not limited to income, employment and social insurance taxes, as shall be required by law. Employee acknowledges and represents that the Company has not provided any tax advice to him in connection with this Agreement and
that he has been advised by the Company to seek tax advice from his own tax advisors regarding this Agreement and payments that may be made to him pursuant to this Agreement, including specifically, the application of the provisions of
Section 409A of the Code to such payments. 
 [Signature Page Follows] 

 

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 IN WITNESS WHEREOF, the undersigned have executed this Agreement as of the date first
forth above. 
  

					
	BIODELIVERY SCIENCES INTERNATIONAL, INC.
		
	By:	 	 /s/ Mark A. Sirgo

		 	Name:	 	Mark A. Sirgo
		 	Title:	 	President and CEO
	
	 /s/ Benny Ward

	Benny Ward

 [Signature Page
to Employment Agreement] 
  

 11Confidentiality, Intellectual Property and Non-Competition Agreement

 Exhibit 10.2 

CONFIDENTIALITY, INTELLECTUAL PROPERTY 

AND NON-COMPETITION AGREEMENT 

This CONFIDENTIALITY, INTELLECTUAL PROPERTY AND NON-COMPETITION AGREEMENT (this “Agreement”) is entered into
effective for all purposes as of September 7, 2010 by Benny Ward (“Employee”) in favor of BioDelivery Sciences International, Inc., a Delaware corporation (the “Company”). 

In consideration of and as a condition to the Company’s employment of Employee and of Employee providing employment services to the
Company, Employee hereby agrees as follows: 
 1. Confidentiality. At all times, Employee shall keep confidential, except
as the Company may otherwise consent to in writing, and not disclose, or make any use of except for the benefit of the Company, at any time either during or subsequent to performance by Employee of services for the Company, any trade secrets,
confidential information, knowledge, data or other information of the Company relating to products, processes, know-how, intellectual property, technical data, designs, formulas, test data, customer lists, business plans, marketing and manufacturing
plans and strategies, and pricing strategies or other subject matter pertaining to any business of the Company or any of its partners, customers, consultants, licensors, licensees or affiliates (collectively, the “Confidential
Information”), which Employee may produce, obtain or otherwise learn of during the course of Employee’s employment with the Company. The “Confidential Information” shall not include information that is or becomes part of the
public domain not as a result of any inaction or action of the Employee. Employee shall not deliver, reproduce, or in any way allow any such Confidential Information to be delivered to or used by any third parties for any purpose (including, without
limitation, any purpose harmful to or competetive with the interests of the Company) without the specific direction or consent of a duly authorized representative of the Company. Employee acknowledges and agrees that some of the Confidential
Information may be considered “material non-public information” for purposes of the federal securities laws (“Insider Information”) and that the Employee will abide by all securities laws relating to the handling of and
acting upon Insider Information. 
 2. Return of Confidential Material. Upon the termination the Employee’s
employment with the Company, Employee shall promptly surrender and deliver to the Company all records, materials, equipment, drawings, documents, lab notes and books and data of any nature pertaining to any Invention (as defined below) or
Confidential Information of the Company or to the services provided by Employee, and Employee will not take or retain (in any form or format) any description containing or pertaining to any Confidential Information which Employee may produce or
obtain during the course of Employee’s employment with the Company. 
 3. Assignment of Inventions and Moral Rights.

 (a) Employee hereby assigns and transfers to the Company, on a perpetual, worldwide and royalty-free basis, Employee’s
entire right, title and interest in and to all Inventions. As used in this agreement, the term “Inventions” shall mean all intellectual property, ideas, improvements, designs, discoveries, developments, drawings, notes, documents,
information and/or materials, whether or not patentable and whether or not reduced to practice, made or conceived by Employee (whether made solely by Employee or jointly with others) which: (i) occur or are conceived during the period in which
Employee is employed by or performs services for the Company and (ii) which relate in any manner to drug, nutraceuticals, genes, vaccines, vitamin or other compound delivery technologies involving liposomes, proteoliposomes, cochleates, buccal,
transmucosal, transdermal, oral or other applications 
  

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and/or derivatives thereof (“Delivery Technologies”), applications of the Delivery Technologies to specific drugs, nutraceuticals, genes, vaccines, vitamins or other compounds,
or result from any task of any nature assigned to or undertaken by Employee or any work performed by Employee for or on behalf of the Company or any of its affiliates. 

(b) Employee hereby irrevocably transfers and assigns to the Company any and all Moral Rights that Employee may have in any Inventions.
Employee also hereby forever waives and agrees never to assert against the Company, its successors or licensees any and all Moral Rights which Employee may have in any Inventions, even after termination of Employee’s employment with the
Company. For purposes of this Agreement, the term “Moral Rights” means any right to claim authorship of a work, any right to object to any distortion or other modification of a work, and any similar right, existing under the law of
any country in the world, or under any treaty. 
 4. Disclosure of Inventions. In connection with all Inventions
contemplated by Section 3 hereof: 
 (a) Employee will disclose all Inventions promptly in writing to the Chief Executive
Officer of the Company in order to permit the Company to enforce and perfect the rights to which the Company is entitled under this Agreement; 

(b) Employee will, at the Company’s request, promptly execute a written assignment of title to the Company for any Invention, and
Employee will preserve all Inventions as Confidential Information in accordance with the terms hereof; and 
 (c) Upon request,
Employee will assist the Company or its nominee (at the Company’s expense) during and at any time during or subsequent to the performance of services by Employee for the Company in every reasonable way in obtaining for the Company’s own
benefit patents and copyrights for all Inventions in any and all countries, which Inventions shall be and remain the sole and exclusive property of the Company or its nominee, whether or not patented or copyrighted. Employee will execute such papers
and perform such lawful acts as the Company deems to be necessary to allow the Company to exercise all rights, title and interest in such patents and copyrights. 

5. Execution of Documents. In connection with this Agreement, Employee will execute, acknowledge and deliver to the Company or its
nominee upon request and at the Company’s expense all such documents, including applications for patents and copyrights and assignments of all Inventions, patents and copyrights to be issued therefore, as the Company may determine necessary or
desirable to apply for and obtain letters patent and copyrights on all Inventions in any and all countries and/or to protect the interest of the Company or its nominee in Inventions, patents and copyrights and to vest title thereto in the Company or
its nominee. 
 6. Maintenance of Records. Employee will keep and maintain adequate and current written records of all
Inventions made by Employee (in the form of notes, sketches, drawings and as may be specified by the Company), which records shall be available to and remain the sole property of the Company at all times. 

7. Prior Inventions. It is understood that all ideas, improvements, designs and discoveries, whether or not patentable and whether
or not reduced to practice, which Employee made prior to the time the Company and Employee began to consider any possible performance of services by Employee to the Company (herein referred to as “Excluded Inventions”) are excluded
from the definition of Inventions as used herein. Set forth on Exhibit A attached hereto is a complete list of all Excluded Inventions, including numbers of all patents and patent applications, and a brief description of all unpatented

  

 2 

 
inventions which are not the property of another party (including, without limitation, a current or previous contracting party). The list is complete and if no items are included on Exhibit
A, Employee shall be deemed to have no such prior inventions within the definition of Inventions. Employee will notify the Company in writing before Employee makes any disclosure or performs any work on behalf of the Company which appears to
threaten or conflict with proprietary rights Employee claims in any such Invention or idea. In the event of Employee’s failure to give such notice, Employee will make no claim against the Company with respect to any such inventions or ideas.

 8. Other Obligations. Employee acknowledges that the Company, from time to time, may have agreements with other
persons or entities or with the U.S. Government, or agencies thereof, which impose obligations or restrictions on the Company regarding inventions made during the course of work thereunder or regarding the confidential nature of such work. Employee
will be bound by all such obligations and restrictions and will take all action necessary to discharge the obligations of the Company thereunder. 

9. Trade Secrets of Others. Employee represents that Employee’s performance of all the terms of this Agreement and as an
employee of the Company does not and will not breach any agreement to keep in confidence proprietary information, knowledge or data acquired by Employee in confidence or in trust, and Employee will not disclose to the Company, or induce the Company
to use, any confidential or proprietary information or material belonging to any other person or entity. Employee will not enter into any agreement, either written or oral, in conflict herewith. 

12. Injunctive Relief. Employee agrees that this Agreement is important to and gravely effects the effective and successful
conduct of the business of the Company, and it effects its reputation and good will, and is necessary to protect the legitimate business interests of the Company. Employee recognizes and agrees that the Company will suffer irreparable injury in the
event of Employee’s breach of any covenant or agreement contained herein and cannot be compensated by monetary damages alone. Employee therefore agrees that the Company, in addition to and without limiting any other remedies or rights that it
may have, either under this Agreement or otherwise, shall have the right to obtain injunctive relief, both temporary and permanent, against the Employee from any court of competent jurisdiction, without the necessity of proving actual damages and
without the necessity of posting bond or other security. Employee agrees to pay the Company’s reasonable attorney’s fees and costs for enforcement of this Agreement, if the Employee breaches this Agreement. 

13. Modification. This Agreement may not be changed, modified, released, discharged, abandoned, or otherwise amended, in whole or
in part, except by an instrument in writing, signed by Employee and by the Company. Any subsequent change or changes in the relationship between the Company and Employee or in Employee’s compensation by the Company shall not affect the validity
or scope of this Agreement. 
 14. Reasonable Terms. Employee acknowledges and agrees that the restrictive covenants
contained in this Agreement have been reviewed by Employee with the benefit of counsel and that such covenants are reasonable in all of the circumstances for the protection of the legitimate business interests of the Company. 

15. Entire Agreement. Employee acknowledges receipt of this Agreement, and agrees that with respect to the subject matter thereof
it is Employee’s entire agreement with the Company, superseding any previous oral or written communications, representations, understandings, or agreements with the Company or any officer or representative thereof. 

 

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 16. Severabilitv. In the event that any paragraph or provision of this Agreement
shall be held to be illegal or unenforceable, the entire Agreement shall not fail on account thereof. It is further agreed that if any one or more of such paragraphs or provisions shall be judged to be void as going beyond what is reasonable in all
of the circumstances for the protection of the interests of the Company, but would be valid if part of the wording thereof were deleted or the period thereof reduced or the range of activities covered thereby reduced in scope, the said reduction
shall be deemed to apply with such modifications as may be necessary to make them valid and effective and any such modification shall not thereby affect the validity of any other paragraph or provisions contained in this Agreement. 

17. Successors and Assigns. This Agreement shall be binding upon the heirs, executors, administrators or other legal
representatives of Employee and is for the benefit of the Company, its successors and assigns. Employee may not assign Employee’s rights or delegate Employee’s duties under this Agreement either in whole or in part without the prior
written consent of the Company. Any attempted assignment or delegation without such consent will be null and void. 
 18.
Governing Law. This Agreement shall be governed by the laws of the State of Delaware except for any conflicts of law rules thereof which might direct the application of the substantive laws of another state. 

19. Counterparts. This Agreement may be signed in two counterparts, each of which may be delivered by facsimile or other
electronic transmission and each of which shall be deemed an original and both of which shall together constitute one agreement. 
  

			
		 	EXECUTED as of the date set forth below.
		
		 	 /s/ Benny Ward

		 	Benny Ward

  

					
	Accepted and Agreed:
	
	BIODELIVERY SCIENCES INTERNATIONAL, INC.
		
	By:	 	 /s/ Mark A. Sirgo

		 	Name:	 	Mark A. Sirgo
		 	Title:	 	President and CEO

 [Signature Page to
Confidentiality, Intellectual Property and Non-Competition Agreement] 
  

 4 

 EXHIBIT A TO 

CONFIDENTIALITY, INTELLECTUAL PROPERTY 

AND NON-COMPETITION AGREEMENT 

PRIOR INVENTIONS WITHIN THE SCOPE OF ASSIGNMENT 

The following is a complete list of all inventions or improvements patented or, unpatented, that have been made or conceived or first
reduced to practice by the undersigned alone or jointly with others prior to the time the Company and the undersigned first began to consider the undersigned’s performance of services for the Company. The undersigned desires to remove the
inventions and improvements listed, if any, from the operation of the foregoing Agreement. 
 Check one: 

 

	x	No inventions or improvements. 

  

	 ̈	As follows: 

 Additional sheets
attached. 
  

			
	Dated: September 7, 2010	 	 /s/ Benny Ward

		 	 Benny Ward

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