Document:

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                                                                   EXHIBIT 10.17

                                                                  Execution Copy

                             PHYSIOME SCIENCES, INC.

                              AGREEMENT TO PURCHASE

                            ALL OF THE CAPITAL STOCK

                         OF PREDIX PHARMACEUTICALS, LTD.

                            DATED AS OF JULY 1, 2003

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                                TABLE OF CONTENTS

<TABLE>
<S>                                                                                      <C>
1.  Purchase of Shares..........................................................          1

    1.1      Purchase of Shares.................................................          1
    1.2      Agreement of Sale..................................................          1
    1.3      Options and Warrants of Predix.....................................          1

2.  The Closing.................................................................          1

3.  Representations of Predix...................................................          3

    3.1      Organization and Standing..........................................          3
    3.2      Subsidiaries, Etc..................................................          3
    3.3      Capitalization.....................................................          4
    3.4      Sale and Delivery of Shares........................................          5
    3.5      Authority for Agreement, No Conflict...............................          5
    3.6      Governmental Consents..............................................          6
    3.7      Litigation.........................................................          6
    3.8      Financial Statements...............................................          6
    3.9      Absence of Undisclosed Liabilities.................................          7
    3.10     Absence of Changes.................................................          7
    3.11     Taxes..............................................................          7
    3.12     Property and Assets................................................          8
    3.13     Intellectual Property..............................................          9
    3.14     Insurance..........................................................         10
    3.15     Material Contracts and Obligations.................................         10
    3.16     Compliance.........................................................         11
    3.17     Employees..........................................................         11
    3.18     ERISA..............................................................         13
    3.19     Books and Records..................................................         13
    3.20     Permits............................................................         13
    3.21     Environmental Matters..............................................         13
    3.22     Grants, Incentives and Subsidies...................................         14
    3.23     Encryption and Other Restricted Technology.........................         15
    3.24     Disclosures........................................................         15

4.  Representations of the Sellers..............................................         15

    4.1      Share Ownership....................................................         15
    4.2      Authority of Seller................................................         15
    4.3      Disclosures........................................................         16
    4.4      Waiver of Claims...................................................         16

5.  Representations of Physiome.................................................         16

    5.1      Authority..........................................................         16
    5.2      Experience.........................................................         16
    5.3      Board of Directors of Subsidiary...................................         16
</TABLE>

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<TABLE>
<S>                                                                                      <C>
6.  Predix Conduct Prior to Closing and Conditions to Closing; Termination......         17

    6.1      Predix Conduct Prior to Closing....................................         17
    6.2      Conditions to Closing..............................................         17
    6.3      Termination........................................................         19

7.  Miscellaneous...............................................................         19

    7.1      Successors and Assigns.............................................         19
    7.2      Survival of Representations and Warranties.........................         19
    7.3      Brokers............................................................         19
    7.4      Severability.......................................................         19
    7.5      Specific Performance...............................................         20
    7.6      Governing Law; Jurisdiction........................................         20
    7.7      Notices............................................................         20
    7.8      Complete Agreement.................................................         21
    7.9      Amendments and Waivers.............................................         21
    7.10     Required Disclosures...............................................         21
    7.11     Pronouns...........................................................         21
    7.12     Counterparts; Facsimile Signatures.................................         21
    7.13     Section Headings and References....................................         21
</TABLE>

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                                    EXHIBITS

Exhibit A    -  List of Sellers and Shares Sold

Exhibit A1   -  Options Granted

Exhibit B    -  Exceptions to Representations

Exhibit C    -  Form of Intellectual Property Assignment Agreement

Exhibit D    -  Form of Amended and Restated Certificate of Incorporation of
                Physiome Sciences, Inc.

Exhibit 2(d) -  Predix Deliverables

Exhibit 6.2  -  Closing Conditions

                                    - iii -

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                             PHYSIOME SCIENCES, INC.

                        AGREEMENT TO PURCHASE ALL OF THE
                                CAPITAL STOCK OF
                          PREDIX PHARMACEUTICALS, LTD.

      This Agreement, dated as of July 1, 2003, is entered into by and among
Physiome Sciences, Inc., a Delaware corporation ("Physiome"), Predix
Pharmaceuticals, Ltd., a corporation formed under the laws of Israel ("Predix
Ltd."), Predix Pharmaceuticals, Inc., a Delaware corporation and a wholly owned
subsidiary of Predix Ltd. ("Predix Inc." and, together with Predix Ltd.,
"Predix") and the individuals and entities listed on Exhibit A (the "Sellers").
In consideration of the mutual promises and covenants contained in this
Agreement, the parties hereto agree as follows:

            1. Purchase of Shares.

            1.1 Purchase of Shares. Subject to the terms and conditions of this
Agreement, at the Closing, Physiome will purchase from each of the Sellers, and
each of the Sellers will sell to Physiome, the number of Preferred Shares of
Predix Ltd. and the number of Ordinary Shares of Predix Ltd. (constituting all
of the outstanding shares of Predix Ltd. and having an aggregate fair market
value of US$7,710,000) set forth opposite such Seller's name on Exhibit A for
the aggregate purchase consideration set forth opposite each Sellers' name on
Exhibit A, which consideration shall be payable in shares of Physiome Capital
Stock and related securities issued under the Sale Agreement, as defined below
(the "Purchase Price"). The Preferred Shares and Ordinary Shares of Predix Ltd.
purchased under this Agreement are referred to herein as the "Shares."

            1.2 Agreement of Sale. The parties hereto each acknowledge and agree
that: (i) the Closing shall occur simultaneous with and shall be conditioned
upon the closing of the transactions contemplated by that certain Physiome
Sciences, Inc. Convertible Preferred Stock Agreement of Sale of even date
herewith (the "Sale Agreement"); and (ii) that the Purchase Price herein shall
be offset in full against the "Purchase Price" (as defined in the Sale
Agreement) to be paid by the Sellers in accordance with the Sale Agreement.

            1.3 Options and Warrants of Predix. At the Closing, all outstanding
options and warrants to purchase shares of Predix capital stock shall be
canceled and the holders thereof shall be granted options to purchase shares of
Physiome Capital Stock as set forth on Exhibit Al hereto.

      2. The Closing. Subject to the terms and conditions of this Agreement, the
closing (the "Closing") of the purchase and sale of the Shares under this
Agreement shall take place at the offices of Hale and Dorr LLP, 650 College Road
East, 4th Floor, Princeton, New Jersey 08540 (or remotely via the exchange of
documents and signatures) on the date that is three (3) business days after the
satisfaction or waiver of all of the conditions to the obligations of the
Parties to consummate the transactions contemplated hereby (the "Closing Date").
At the Closing the following transactions shall occur, which transactions shall
be deemed to take place

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simultaneously and no transaction shall be deemed to have been completed or any
document delivered until all such transactions have been completed and all such
documents delivered:

                  (a) Predix Ltd. shall deliver to Physiome a certified copy of
its Certificate of Incorporation, dated as of the most recent practicable date,
from the Israeli Registrar of Companies, evidencing that Predix Ltd. is a
company registered under Israeli law;

                  (b) Predix Inc. shall deliver to Physiome certificates, as of
the most recent practicable dates, (i) as to the corporate good standing of
Predix Inc. issued by the Secretary of State of the State of Delaware, and (ii)
as to the due qualification of Predix Inc. as a foreign corporation issued by
the Secretary of the Commonwealth of Massachusetts;

                  (c) Physiome shall deliver to the Sellers certificates, as of
the most recent practicable dates, (i) as to the corporate good standing of
Physiome issued by the Secretary of State of the State of Delaware and (ii) as
to the due qualification of Physiome as a foreign corporation issued by the
Secretary of State of New Jersey;

                  (d) Predix Ltd. shall deliver to Physiome a duly signed
shareholders' resolution together with a duly executed notice ready for filing
with the Israeli Registrar of Companies (in the forms of Exhibits 2(d)(1) and
Exhibit 2(d)(2), respectively, adopting the amended articles of association of
Predix Ltd. (in the form of Exhibit 2(d)(3) hereto));

                  (e) Predix Inc. shall deliver to Physiome the Certificate of
Incorporation of Predix Inc. as amended and in effect as of the Closing Date
certified by the Secretary of State of the State of Delaware;

                  (f) Physiome shall deliver to the Sellers the Certificate of
Incorporation of Physiome as amended and in effect as of the Closing Date
certified by the Secretary of State of the State of Delaware;

                  (g) Predix Ltd. shall deliver to Physiome duly executed copies
of the resolutions of the Board of Directors and shareholders of Predix Ltd.,
authorizing and approving all matters in connection with this Agreement and the
transactions contemplated hereby;

                  (h) Predix Inc. shall deliver to Physiome a Certificate of the
Secretary of Predix Inc. attesting as to (i) the By-laws of Predix Inc.; (ii)
the signatures and titles of the officers of Predix Inc. executing this
Agreement or any of the other agreements to be executed and delivered by Predix
Inc. at the Closing; and (iii) resolutions of the Board of Directors and
stockholders of Predix Inc., authorizing and approving all matters in connection
with this Agreement and the transactions contemplated hereby;

                  (i) Physiome shall deliver to the Sellers a Certificate of the
Secretary of Physiome attesting as to (i) the By-laws of Physiome; (ii) the
signatures and titles of the officers of Physiome executing this Agreement or
any of the other agreements to be executed and delivered by Physiome at the
Closing; and (iii) resolutions of the Board of Directors and stockholders of
Physiome, authorizing and approving all matters in connection with this
Agreement and the transactions contemplated hereby;

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                  (j) each of the Sellers shall deliver to Physiome all of their
certificates and a share transfer deed for the number of Shares set forth
opposite such respective Sellers' name on Exhibit A, registered in the name of
each such respective Seller;

                  (k) Predix Ltd.. shall deliver to Physiome duly executed
Notices of Transfer of Shares ready for filing with the Israeli Registrar of
Companies and a copy of Predix Ltd.'s internal Share Registry recording the
transfer of the Shares from the Sellers to Physiome;

                  (l) Physiome shall tender to each Seller, the Purchase Price
for the Shares being purchased from the Seller; and

                  (m) a duly executed Sale Agreement shall be delivered to each
of the parties hereto.

            3. Representations of Predix. Except as disclosed by Predix in
      Exhibit B hereto, Predix hereby represents and warrants to Physiome that
      the statements contained in this Section 3 are complete and accurate as of
      the date of this Agreement. Exhibit B shall be arranged in sections
      corresponding to the numbered and lettered sections and subsections
      contained in this Section 3, and the disclosures in any section or
      subsection of Exhibit B shall qualify only the corresponding section or
      subsection of this Section 3, unless otherwise specified.

            3.1 Organization and Standing. Predix Ltd. is a corporation duly
organized, validly existing and in good standing under the laws of Israel and
has full corporate power and authority to conduct its business as presently
conducted and as proposed to be conducted by it and to enter into and perform
this Agreement and all other agreements required to be executed by Predix Ltd.
at or prior to the Closing pursuant to Section 2 (the "Ancillary Agreements")
and to carry out the transactions contemplated by this Agreement and the
Ancillary Agreements. Predix Ltd. is duly qualified to do business as a foreign
corporation and is in good standing in the Commonwealth of Massachusetts and in
every other jurisdiction in which the failure so to qualify would have a
material adverse effect on the business, prospects, assets or condition
(financial or otherwise) of Predix Ltd. and its Subsidiary (as defined below) (a
"Predix Ltd. Material Adverse Effect"). Predix Ltd. has furnished to Physiome
complete and accurate copies of its memorandum and articles of association, each
as amended to date and presently in effect. Predix Ltd. has at all times
complied with all provisions of its memorandum and articles of association and
is not in default under, or in violation of, any such provision.

            3.2 Subsidiaries, Etc. Predix Inc. (the "Subsidiary") is a Delaware
corporation and a wholly owned subsidiary of Predix Ltd. There is no other
corporation, partnership, trust, limited liability company or other
non-corporate business enterprise in which Predix holds stock or other ownership
interests ("Ownership Units") representing (i) more than 50% of the voting power
of all outstanding capital stock or Ownership Units of such entity or (ii) the
right to receive more than 50% of the net assets of such entity available for
distribution to the holders of capital stock or Ownership Units upon a
liquidation or dissolution of such entity. Predix Inc. is duly organized,
validly existing and in good standing under the laws of the jurisdiction of its
organization. Predix Inc. is duly qualified to conduct business and is in good
standing under the laws of each jurisdiction in which the nature of its
businesses or the ownership or leasing of its properties requires such
qualification, except where the failure to so qualify would not have a material
adverse effect on the business, properties or rights of Predix Inc. Predix Inc.
has all requisite power and authority to carry on the businesses in which it is
engaged and to own and

                                     - 3 -

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use the properties owned and used by it. Predix Ltd. has delivered or made
available to Physiome complete and accurate copies of the organizational
documents, such as any memorandum and articles of association, certificate of
incorporation and By-laws (the "Organizational Documents"), of Predix Inc., as
amended to date. All of the issued and outstanding shares of capital stock or
Ownership Units of Predix Inc. are duly authorized, validly issued, fully paid,
nonassessable and are held of record and beneficially by Predix Ltd., free and
clear of any restrictions on transfer (other than restrictions under the
Securities Act and state securities laws), claims, security interests, options,
warrants, rights, contracts, calls, commitments, equities and demands. There are
no outstanding or authorized options, warrants, rights, agreements or
commitments to which Predix Ltd. or Predix Inc. is a party or which are binding
on any of them providing for the issuance, disposition or acquisition of any
capital stock or Ownership Units of Predix Inc. There are no outstanding stock
appreciation, phantom stock or similar rights with respect to Predix Inc. There
are no voting trusts, proxies or other agreements or understandings with respect
to the voting of any capital stock or Ownership Units of Predix Inc. Predix Inc.
is not in default under or in violation of any provision of any of its
Organizational Documents. Except for Predix Inc., Predix Ltd. does not own or
control, directly or indirectly, any shares of capital stock of any other
corporation or any interest in any partnership, limited liability company, joint
venture or other non-corporate business enterprise. Exhibit B further sets forth
the Board of Directors of Predix Inc. effective as of the Closing.

            3.3 Capitalization.

                  (a) The authorized capital of Predix Ltd. (immediately prior
to the Closing) is NIS 3,371,912 divided into (i) 1,630,178 Ordinary Shares, of
nominal value NIS 0.10 each; (ii) 16,044,471 Ordinary A Shares, of nominal value
NIS 0.10 each, and (iii) 16,044,471 Preferred A Shares, of nominal value NIS
0.10 each

                  (b) Exhibit B includes a complete and accurate list, as of the
date of the Agreement, of the holders of Predix Ltd.'s share capital, showing
the number of shares and other equity securities of Predix Ltd., and the class
or series of such shares and equity securities, held by each shareholder and the
number of Ordinary Shares (if any) into which such shares and equity securities
are convertible, both immediately prior to and immediately following the
Closing. None of such outstanding shares and equity securities constitute
restricted stock or are otherwise subject to a repurchase or redemption right.
All of the issued and outstanding shares of Predix Ltd. have been duly
authorized and validly issued and are fully paid and nonassessable. All of the
issued and outstanding shares of Predix Ltd. have been offered, issued and sold
by Predix Ltd. in compliance with all applicable foreign, federal and state
securities laws.

                  (c) Exhibit B includes a complete and accurate list, as of the
date of this Agreement of, and sets forth information both immediately prior to
and immediately following the Closing with respect to: (i) all share option
plans and other share or equity-related plans of Predix Ltd. (the "Predix Ltd.
Stock Plans"), indicating for each Predix Ltd. Stock Plan the number of Ordinary
Shares issued to date under such Predix Ltd. Stock Plan, the number of shares
subject to outstanding options under such Predix Ltd. Stock Plan and the number
of shares reserved for future issuance under such Predix Ltd. Stock Plan; (ii)
all holders of outstanding options to purchase Preferred Shares or Ordinary
Shares ("Predix Ltd. Stock Options"), indicating with respect to each Predix
Ltd. Stock Option the Predix Ltd. Stock Plan under which it was granted, the
number of Preferred Shares or Ordinary Shares subject to such Predix Ltd. Stock
Option, the exercise price, the date of grant, and the vesting schedule
(including any

                                     - 4 -

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acceleration provisions with respect thereto); and (iii) all holders of warrants
or other rights (other than Predix Ltd. Stock Options and outstanding
convertible preferred shares) to purchase or acquire shares of Predix Ltd.
("Predix Ltd. Warrants"), indicating with respect to each Predix Ltd. Warrant
the agreement or other document under which it was granted, the number of
shares, and the class or series of such shares, subject to such Predix Ltd.
Warrant, the exercise price, the date of issuance and the expiration date
thereof. Predix Ltd. has furnished to Physiome complete and accurate copies of
all Predix Ltd. Stock Plans, forms of all stock option agreements evidencing all
Predix Ltd. Stock Options and all Predix Ltd. Warrants. All of the shares of
Predix Ltd. subject to Predix Ltd. Stock Options and Predix Ltd. Warrants will
be, upon issuance pursuant to the exercise of such instruments, duly authorized,
validly issued, fully paid and nonassessable.

                  (d) Upon Closing: (i) No subscription, warrant, option,
convertible security or other right (contingent or otherwise) to purchase or
acquire any shares of Predix Ltd. is authorized or outstanding, (ii) Predix Ltd.
has no obligation (contingent or otherwise) to issue any subscription, warrant,
option, convertible security or other such right, or to issue or distribute to
holders of any of its shares any evidences of indebtedness or assets of Predix
Ltd., and (iii) Predix Ltd. has no obligation (contingent or otherwise) to
purchase, redeem or otherwise acquire any shares or any interest therein or to
pay any dividend or to make any other distribution in respect thereof.

                  (e) Except for the Ancillary Agreements, the Founders
Agreement by and among Predix, Prof. Haim Aviv, Dr. Silvia Noiman, Dr. Oren
Becker, Zvi Naor and Ramot at Tel Aviv University Ltd., dated September 18,
2000, and for agreements that will be cancelled at Closing, there is no
agreement, written or oral, between Predix Ltd. and any holders of its
securities, or, to the best of Predix Ltd.'s knowledge, among any holder of its
securities, relating to the sale or transfer (including without limitation
agreements relating to rights of first refusal, co-sale rights or "drag-along"
rights), registration under the Securities Act of 1933, as amended (the
"Securities Act"), or the securities laws of any country or jurisdiction or,
voting, of the capital stock of Predix Ltd.

            3.4 Sale and Delivery of Shares. The sale and delivery of the Shares
in accordance with this Agreement, and the delivery of the Ordinary Shares
issuable upon conversion of the Preferred Shares, have been duly authorized by
all necessary corporate action on the part of Predix Ltd., and all such shares
not yet issued have been duly reserved for issuance. The Shares are and the
Ordinary Shares issuable upon conversion of the Preferred Shares will be duly
and validly issued, fully paid and nonassessable and are free and clear from any
third party right whatsoever.

            3.5 Authority for Agreement, No Conflict. The execution, delivery
and performance by Predix of this Agreement and the Ancillary Agreements, and
the consummation by Predix of the transactions contemplated hereby and thereby,
have been duly authorized by all necessary corporate action. This Agreement has
been, and the Ancillary Agreements when executed at the Closing will be, duly
executed and delivered by Predix and constitute valid and binding obligations of
Predix enforceable in accordance with their respective terms, subject as to
enforcement of remedies to applicable bankruptcy, insolvency, reorganization,
moratorium or similar laws affecting generally the enforcement of creditors'
rights and subject to a court's discretionary authority with respect to the
granting of a decree ordering specific performance or other equitable remedies.
The execution and delivery of this Agreement and the Ancillary

                                     - 5 -

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Agreements, the consummation of the transactions contemplated hereby and thereby
and the compliance with their respective provisions by Predix will not (a)
conflict with or violate any provision of the memorandum and articles of
association of Predix Ltd., or the Certificate of Incorporation or Bylaws of
Predix Inc., (b) require on the part of Predix Ltd. or Predix Inc., any filing
with, or any permit, order, authorization, consent or approval of any court,
arbitrational tribunal, administrative agency or commission or other
governmental or regulatory authority or agency (each of the foregoing is
hereafter referred to as a "Governmental Entity") other than the filing of
notices for the transfer of the Shares with the Israeli Registrar of Companies,
(c) conflict with, result in a breach of, constitute (with or without due notice
or lapse of time or both) a default under, result in the acceleration of
obligations under, create in any party the right to accelerate, terminate,
modify or cancel, or require any notice, consent or waiver under, any contract,
lease, sublease, license, sublicense, franchise, permit, indenture, agreement or
mortgage for borrowed money, instrument of indebtedness, Security Interest (as
defined below) or other arrangement to which Predix Ltd., or Predix Inc., is a
party or by which Predix Ltd., or Predix Inc., is bound or to which any of its
assets are subject, other than any of the foregoing events listed in this clause
(c) which do not and will not, individually or in the aggregate, have a Predix
Ltd. Material Adverse Effect, (d) result in the imposition of any Security
Interest upon any assets of Predix Ltd., or Predix Inc., or (e) violate any
order, writ, injunction, decree, statute, rule or regulation applicable to
Predix Ltd., or Predix Inc., or any of its properties or assets. For purposes of
this Agreement, "Security Interest" means any mortgage, pledge, security
interest, encumbrance, charge, or other lien (whether arising by contract or by
operation of law).

            3.6 Governmental Consents. No consent, approval, order or
authorization of, or registration, qualification, designation, declaration or
filing with, any Governmental Entity is required on the part of Predix in
connection with the sale and delivery of the Shares, the issuance and delivery
of the Ordinary Shares issuable upon conversion of the Preferred Shares or the
other transactions to be consummated at the Closing, as contemplated by this
Agreement and the Ancillary Agreements, except such filings as shall have been
made prior to and shall be effective on and as of the Closing and such filings
required to be made after the Closing under applicable foreign, federal and
state securities laws, all of which filings are specified in Exhibit B.

            3.7 Litigation. There is no action, suit or proceeding, or
governmental inquiry or investigation, pending, or, to the best of Predix'
knowledge, any basis therefor or threat thereof, against Predix, which questions
the validity of this Agreement, the Ancillary Agreements or the right of Predix,
to enter into any such agreements, or which might result, either individually or
in the aggregate, in a Predix Ltd. Material Adverse Effect. There is no
litigation pending, or, to the best of Predix' knowledge, any basis therefor or
threat thereof, against Predix or any of its employees by reason of the past
employment relationships of any of the employees, the proposed activities of
Predix, or negotiations by Predix with possible investors in Predix. Predix is
not subject to any outstanding judgment, order or decree.

            3.8 Financial Statements. Predix Ltd. has furnished to Physiome a
complete and accurate copy of (i) the audited consolidated balance sheet of
Predix Ltd. at December 31, 2002 and the related audited statements of
operations and cash flows for the fiscal year then ended, and (ii) the unaudited
consolidated balance sheet of Predix Ltd. (the "Balance Sheet") at April 30,
2003 (the "Balance Sheet Date") and the related statements of operations and
cash flows for the three months then ended, (collectively, the "Financial
Statements"). The Financial Statements are in accordance with the books and
records of Predix Ltd., present fairly the financial condition and results of
operations of Predix Ltd., at the dates and for the periods

                                     - 6 -

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indicated, and have been prepared in accordance with Israeli generally accepted
accounting principles ("GAAP") consistently applied, except that the unaudited
Financial Statements may not be in accordance with GAAP because of the absence
of footnotes normally contained therein and are subject to normal year-end audit
adjustments which in the aggregate will not be material.

            3.9 Absence of Undisclosed Liabilities. Predix does not have any
liability (whether known or unknown and whether absolute or contingent), except
for (a) liabilities shown on the consolidated Balance Sheet and (b) liabilities
not in excess of $10,000 in the aggregate which have arisen since the Balance
Sheet Date in the ordinary course of business and (c) contractual liabilities
incurred in the ordinary course of business which are not required by GAAP to be
reflected on a balance sheet and which would not, either individually or in the
aggregate, have or result in a Predix Ltd. Material Adverse Effect and (d) the
outstanding balance under the Predix Bridge Loan Financing Agreement entered
into in May 2003, which outstanding balance shall be converted into Preferred A
Shares of Predix Ltd. at Closing, and which share capital is currently included
among the Shares Surrendered and Consideration Received set forth in Exhibit A
hereto.

            3.10 Absence of Changes. Since the Balance Sheet Date, there has
been no material adverse change in the business, prospects, condition (financial
or otherwise), or results of operations of Predix, other than changes occurring
in the ordinary course of business (which ordinary course changes have not,
individually or in the aggregate, had a Predix Ltd. Material Adverse Effect).
Notwithstanding the foregoing, any adverse results (without regard to magnitude
or impact on Predix) in the lead optimization of compounds under development
have been reported to Physiome.

            3.11 Taxes.

                  (a) With respect to each Predix entity, and only to the extent
applicable to it, "Taxes" shall mean all taxes or other similar assessments or
liabilities, including without limitation, income, gross receipts, ad valorem,
premium, value-added, excise, real property, personal property, assets, sales,
use, transfer, withholding, employment, unemployment, insurance, social
security, business license, national insurance, business organization,
environmental, workers compensation, payroll, profits, license, lease, service,
service use, severance, stamp, occupation, windfall profits, customs, duties,
franchise, net worth, capital stock, gains and other taxes imposed by the United
States or Israel, or any state, local or foreign government, or any agency
thereof, or other political subdivision of the United States or Israel or any
such government, and any interest, fines, penalties, assessments or additions to
tax resulting from, attributable to or incurred in connection with any tax or
any contest or dispute thereof. '"Tax Returns" shall mean all reports, returns,
declarations, statements or other information required to be filed with a taxing
authority in connection with Taxes.

                  (b) Predix has paid all Taxes due and payable by Predix on or
before the date hereof. Management believes that the unpaid Taxes of Predix do
not exceed the reserve for actual Taxes (as opposed to any reserve for deferred
Taxes established to reflect timing differences between book and Tax income) as
shown on the Balance Sheet.

                  (c) Predix has timely filed or has obtained presently
effective extensions (which extensions, if any, are listed on Exhibit B) with
respect to all federal, state, local, Israeli and foreign Tax Returns which are
required to be filed by it, as applicable for each

                                     - 7 -

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Predix entity, such returns are complete and accurate and all Taxes shown
thereon to be due have been timely paid. Predix has not explicitly waived any
statute of limitation with respect to any Tax or agreed to any extension of time
with respect to a Tax assessment or deficiency. The Tax Returns of Predix have
not been under audit or examination by the Internal Revenue Service, the Israel
Income Tax Commission, or other relevant taxing authority, and no controversy
with respect to Taxes of any type is pending or, to the best of Predix'
knowledge, threatened. Predix has not received any final assessments from the
relevant Assessment Officer of the Israel Income Tax Commission.

                  (d) Predix has withheld or collected from each payment made to
its employees, independent contractors, stockholders, creditors and other third
parties the amount of all Taxes required to be withheld or collected therefrom
and has paid all such amounts to the appropriate taxing authorities when due. To
Predix knowledge, it has complied with all information reporting requirements
including maintenance of the required records with respect thereto in connection
with amounts paid to any employee, independent contractor, stockholder, creditor
or other third party.

                  (e) To Predix knowledge, there are no liens for Taxes upon any
Predix assets, other than liens for ad valorem Taxes not yet due and payable.

                  (f) Predix Inc. has disclosed on its federal income Tax
Returns all positions taken therein that could give rise to a substantial
understatement of federal income Tax within the meaning of Section 6662 of the
Code.

                  (g) Predix Inc. has not distributed stock of another
corporation nor has its stock been distributed by another corporation in a
transaction that was purported or intended to be governed in whole or in part by
Section 355 or Section 361 of the Code.

                  (h) Predix Inc.'s net operating losses for federal income Tax
purposes, if any, as set forth in the Financial Statements, are not subject to
any limitations imposed by Section 382 of the Code. Predix Ltd.'s net operating
losses for Israeli Income Tax purposes, as set forth in the Financial
Statements, are not subject to any limitations imposed for Israeli Tax purposes,
and consummation of the transactions contemplated by this Agreement will not
have the effect of limiting Predix Ltd.'s ability to use such net operating
losses in full to offset its Taxable income.

                  (i) Predix is not a party to or member of any joint venture,
partnership, or other arrangement or contract which could be treated as a
partnership for United States or Israeli income Tax purposes.

            3.12 Property and Assets. Predix has good title to, or a valid
leasehold interest in, all of its material properties and assets, including all
properties and assets reflected in the Balance Sheet, except those disposed of
since the date thereof in the ordinary course of business, and none of such
properties or assets is subject to any Security Interest other than those the
material terms of which are described in the Balance Sheet or in Exhibit B.

                                     - 8 -

<PAGE>

            3.13 Intellectual Property.

                  (a) Exhibit B lists each patent, patent application, copyright
registration or application therefor, mask work registration or application
therefor, and trademark, service mark and domain name registration or
application therefor of Predix.

                  (b) Predix owns or has the right to use all Intellectual
Property (as defined below) necessary for the conduct of its business as
currently conducted or as currently proposed to be conducted and to operate the
Internal Systems (as defined below). Predix has taken all reasonable measures to
protect the proprietary nature of each item of Predix Intellectual Property (as
defined below), and to maintain in confidence all trade secrets and confidential
information, that it owns or uses. No other person or entity has any rights to
any of Predix Intellectual Property owned by Predix (except pursuant to
agreements or licenses specified in Exhibit B), and, to the best of Predix'
knowledge, no other person or entity is infringing, violating or
misappropriating any of the Predix Intellectual Property.

                  (c) None of the Predix Intellectual Property infringes or
violates, or constitutes a misappropriation of, any Intellectual Property rights
of any person or entity; and neither the marketing, distribution, provision or
use of any Predix Intellectual Property currently under development by Predix
will, when such Predix Intellectual Property is commercially released by Predix,
infringe or violate, or constitute a misappropriation of, any Intellectual
Property rights of any person or entity that exist today. None of the Internal
Systems, or the use thereof, infringes or violates, or constitutes a
misappropriation of, any Intellectual Property rights of any person or entity.
Exhibit B lists any complaint, claim or notice, or written threat thereof,
received by Predix alleging any such infringement, violation or
misappropriation; and Predix has provided to Physiome complete and accurate
copies of all written documentation in the possession of Predix relating to any
such complaint, claim, notice or threat. Predix has provided to Physiome
complete and accurate copies of all written documentation in Predix' possession
relating to claims or disputes known to Predix concerning any Predix
Intellectual Property.

                  (d) Exhibit B identifies each license or other agreement
pursuant to which Predix has licensed, distributed or otherwise granted any
rights to any third party with respect to, any Predix Intellectual Property.
Except as described in Exhibit B, Predix has not agreed to indemnify any person
or entity against any infringement, violation or misappropriation of any
Intellectual Property rights with respect to any Predix Intellectual Property.

                  (e) Exhibit B identifies each item of Predix Intellectual
Property that is owned by a party other than Predix, and the license or
agreement pursuant to which Predix uses it (excluding off-the-shelf software
programs licensed by Predix pursuant to "shrink wrap" licenses).

                  (f) Predix has not disclosed the source code for any software
developed by it, or other confidential information constituting, embodied in or
pertaining to such software, to any person or entity, and Predix has taken
reasonable measure to prevent disclosure of such source code.

                  (g) All of the copyrightable materials incorporated in or
bundled with the Predix Intellectual Property has been created by employees of
Predix within the scope of their employment by Predix or by independent
contractors of Predix who have executed

                                     - 9 -

<PAGE>

agreements expressly assigning all right, title and interest in such
copyrightable materials to Predix. No portion of such copyrightable materials
was jointly developed with any third party.

                  (h) The Internal Systems are free from significant defects or
programming errors and conform in all material respects to the written
documentation and specifications therefor.

                  (i) Each of Oren Becker, Silvia Noiman, Dale Dhanoa, Sharon
Shacham, Srinivasa Cheruku, Don Gli Chen and Alexander Heifetz (collectively,
the "Inventors") have assigned to Predix all right, title and interest in the
Predix Intellectual Property and to all tangible and intangible property related
to, and used in connection with, the business of Predix as currently being
conducted and as presently proposed to be conducted, in perpetuity (or for the
longest period of time otherwise permitted by law).

                  (j) For purposes of this Agreement, the following terms shall
have the following meanings:

                        (i) "Internal Systems" shall mean the internal systems
of Predix that are used in its business or operations, including, computer
hardware systems, software applications, and embedded systems.

                        (ii) "Intellectual Property" shall mean all: (a)
patents, patent applications, patent disclosures and all related continuation,
continuation-in-part, divisional, reissue, reexamination, utility model,
certificate of invention and design patents, patent applications, registrations
and applications for registrations; (b) trademarks, service marks, trade dress,
Internet domain names, logos, trade names and corporate names and registrations
and applications for registration thereof; (c) copyrights and registrations and
applications for registration thereof; (d) mask works and registrations and
applications for registration thereof, (e) computer software, data and
documentation; (f) inventions, trade secrets and confidential business
information, whether patentable or nonpatentable and whether or not reduced to
practice, know-how, manufacturing and product processes and techniques, research
and development information, copyrightable works, financial, marketing and
business data, pricing and cost information, business and marketing plans and
customer and supplier lists and information; (g) other proprietary rights
relating to any of the foregoing (including remedies against infringements
thereof and rights of protection of interest therein under the laws of all
jurisdictions); and (h) copies and tangible embodiments thereof.

                        (iii) "Predix Intellectual Property" shall mean the
Intellectual Property owned by or licensed to Predix and incorporated in,
underlying or used in connection with the Intellectual Property or the Internal
Systems.

            3.14 Insurance. Predix maintains valid policies of workers'
compensation insurance and of insurance with respect to its properties and
business of the kinds and in the amounts as the management believes is suitable
for companies engaged in the same or similar business and similarly situated,
including, without limitation, insurance against loss, damage, fire, theft,
public liability and other risks.

            3.15 Material Contracts and Obligations. Exhibit B sets forth a list
of all material agreements or commitments of any nature (whether written or
oral) to which Predix is a

                                     - 10 -

<PAGE>

party or by which it is bound, including without limitation (a) any agreement
which requires future expenditures by Predix in excess of US$10,000 in the
aggregate or which might result in payments to Predix in excess of US$10,000 in
the aggregate, (b) any employment and consulting agreements (including any
amendments thereto), employee benefit, bonus, pension, profit-sharing, stock
option, stock purchase and similar plans and arrangements, (c) any distributor,
sales representative or similar agreement, (d) any agreement with any current or
former stockholder, officer or director of Predix, or any "affiliate" or
"associate" of such persons (as such terms are defined in the rules and
regulations promulgated under the Securities Act), including without limitation
any agreement or other arrangement providing for the furnishing of services by,
rental of real or personal property from, or otherwise requiring payments to,
any such person or entity, (e) any agreement under which Predix is restricted
from carrying on any business anywhere in the world, (f) any agreement relating
to indebtedness for borrowed money, (g) any agreement for the disposition of a
material portion of Predix' assets (other than for the sale of inventory in the
ordinary course of business), (h) any agreement for the acquisition of the
business or securities or other ownership interests of another party or (i) any
other agreement that is material to the operations, business or finances of
Predix. Predix has delivered to Physiome copies of the foregoing agreements (or
an accurate summary of any oral agreement). All of such agreements and contracts
are valid, binding and in full force and effect. Neither Predix, nor, to the
best of Predix' knowledge, any other party thereto, is in default of any of its
obligations under any of the agreements or contracts listed on Exhibit B, in a
manner which could have a Predix Material Adverse Effect.

            3.16 Compliance. Predix has, in all material respects, complied with
all laws, regulations and orders applicable to its present and proposed business
and has all material permits and licenses required thereby. There is no term or
provision of any mortgage, indenture, contract, agreement or instrument to which
Predix is a party or by which it is bound, or, to the best of Predix' knowledge,
of any provision of any foreign, state or federal judgment, decree, order,
statute, rule or regulation applicable to or binding upon Predix, which
materially adversely affects or, so far as Predix may now foresee, in the future
is reasonably likely to result in or have a Predix Material Adverse Effect. To
the best of Predix' knowledge, no employee of Predix is in violation of any term
of any contract or covenant (either with Predix or with another entity) relating
to employment, patents, assignment of inventions, proprietary information
disclosure, non-competition or non-solicitation.

            3.17 Employees.

                  (a) All current and former employees of Predix have executed
and delivered non-disclosure and assignment of inventions agreements and, except
as set forth on Exhibit B, all of such agreements are in full force and effect
and none of such agreements will be terminated as a result of or in connection
with the Closing. All current and former employees of Predix have executed and
delivered non-competition and non-solicitation agreements and all of such
agreements are in full force and effect and shall remain in full force and
effect following the Closing. All current and former independent contractors of
Predix that have performed development work or provided technical services to
Predix or have otherwise had access to confidential or proprietary information
of Predix have executed and delivered non-disclosure and assignment of
inventions agreements, copies of which have been delivered to Physiome, and none
of such agreements will be terminated as a result of or in connection with the
Closing.

                                     - 11 -
<PAGE>

                  (b) Except for those employees of Predix who shall become
employees of Physiome, Predix is not aware that any employee of Predix has plans
to terminate his or her employment relationship with Predix. Except as set forth
on Exhibit B, all employees and independent contractors are terminable at will
within 30 days. Except as set forth on Exhibit B, all employees of Predix are
engaged by Predix on a full time basis. Predix has complied in all material
respects with all applicable employment-related laws including, but not limited
to, laws relating to wages, hours, severance pay, equal opportunity,
discrimination, workplace harassment, collective bargaining, workers'
compensation insurance and the payment of social security and other taxes. None
of the employees of Predix is represented by any labor union, and there is no
labor strike or other labor trouble pending with respect to Predix (including,
without limitation, any organizational drive) or, to the best of Predix'
knowledge, threatened. Exhibit B sets forth a list of all agreements between any
Inventor or officer of Predix and a previous employer of such person that
contains non-competition or non-solicitation covenants. Predix has delivered
copies of such agreements to Physiome. No employee of Predix is obligated under
any contract or subject to any judgment, decree or administrative order that
would conflict or interfere with (i) the performance of the employee's duties as
an employee, director or officer of Predix, or (ii) Predix' business as
conducted or proposed to be conducted.

                  (c) Predix has provided to Physiome a list of the salaries and
any bonus arrangements of each employee and independent contractor of Predix.
Such list of all employees of Predix is accurate as of the date of this
Agreement, and correctly reflects, in all material respects, their salaries and
terms and conditions of employment, any other compensation payable to them
(including compensation payable pursuant to bonus, deferred compensation or
commission arrangements, vacation pay balances, replenishment ("havraa") pay
balances, illness pay balances, and fringe benefits including, without
limitation, balances in provident or pension funds, "13th and 14th salary", car,
telephone, or managers insurance), their dates of employment and their positions
and ranks (if any).

                  (d) Predix is not a party to any collective bargaining
contract or other contract with a labor union involving any of its employees
except for those provisions of general agreements between the Federation of
Labor Unions and the Coordination Bureau of Economic Organizations which may be
applicable to certain classes of employees of Predix by virtue of Extension
Orders.

                  (e) Other than the personal employment agreements referred to
in Exhibit B, there are no employment, severance or similar agreements or offer
letters, whether written or unwritten, between Predix and any of its respective
directors, officers, executives or employees which cannot be terminated by
Predix upon thirty (30) days notice without giving rise to a claim for damages
or compensation (except for statutory severance pay).

                  (f) As of the date hereof, there are no pending, or to the
knowledge of Predix threatened, or reasonably anticipated, claims or actions
outstanding against Predix by any person who is now or has been an officer or
employee of Predix, and there have been no material disputes between Predix and
any material number or category of employees. Further, Predix is not aware of
any formal or informal complaints by any employee of Predix of any wrongdoing
which could be construed as a complaint of discrimination, workplace harassment
or wrongful employment-related action or inaction.

                                     - 12 -

<PAGE>

                  (g) The statutory and contractual overtime, severance pay,
accrued vacation, and any other employment-related benefits due to employees of
Predix as of the Closing is either funded or provided for in the Financial
Statements. No cause of action exists giving right to employees to any claim for
compensation for overtime or termination severance pay to which such employee is
entitled and to the knowledge of Predix, no such claims will be made by any
employee for payment of any compensation or provision of any right or benefit as
a result of the change of control of Predix Ltd. contemplated hereby.

                  (h) Predix is not liable for any material arrears of wages or
any penalty for failure to comply with the foregoing.

                  (i) Predix is not liable for any payment to any trust or other
fund governed by or maintained by or on behalf of any governmental authority,
with respect to unemployment compensation benefits, social security or other
benefits or obligations for Employees (other than routine payments to be made in
the normal course of business and consistent with past practice).

                  (j) All amounts which Predix is legally or contractually
required to deduct from its employees' salaries and/or transfer to such
employees' pension or provident, life insurance, incapacity insurance,
continuing education fund or otherwise have been duly paid into the appropriate
fund or funds, and Predix has no outstanding obligation to make any such
transfer or provision on account of overdue payments.

            3.18 ERISA. Exhibit B hereto lists all employee benefit plans (as
defined in Section 3(3) of the Employee Retirement Income Security Act of 1974,
as amended ("ERISA")) maintained by Predix Inc. Each of such employee benefit
plans complies in all material respects with (i) all applicable requirements of
ERISA and (ii) all applicable requirements of the Code.

            3.19 Books and Records. The minute books of Predix contain complete
and accurate records of all meetings and other corporate actions of its
stockholders and its Board of Directors and committees thereof. The internal
Share Registry of Predix is complete and accurate and reflects all issuances,
transfers, repurchases and cancellations of shares of capital stock of Predix.

            3.20 Permits. Exhibit B sets forth a list of all material permits,
licenses, registrations, certificates, orders or approvals from any Governmental
Entity ("Permits") issued to or held by Predix. Such listed Permits are the only
Permits that are required for Predix to conduct its business as presently or
currently expected to be conducted, except for those the absence of which would
not have a Predix Material Adverse Effect. Each such Permit is in full force and
effect and, to the best of Predix' knowledge, no suspension or cancellation of
such Permit is threatened and there is no basis for believing that such Permit
will not be renewable upon expiration.

            3.21 Environmental Matters.

                  (a) Predix has complied with all applicable Environmental Laws
(as defined below), except for violations of Environmental Laws that,
individually or in the aggregate, have not had and would not reasonably be
expected to have a Predix Material Adverse Effect. There is no pending or, to
the best of Predix' knowledge, threatened civil or criminal

                                     - 13 -

<PAGE>

litigation, written notice of violation, formal administrative proceeding, or
investigation, inquiry or information request by any Governmental Entity,
relating to any Environmental Law involving Predix. For purposes of this
Agreement, "Environmental Law" shall mean any foreign, federal, state or local
law, statute, rule or regulation or the common law relating to the environment
or occupational health and safety, including any statute, regulation,
administrative decision or order pertaining to (i) treatment, storage, disposal,
generation and transportation of industrial, toxic or hazardous materials or
substances or solid or hazardous waste; (ii) air, water and noise pollution;
(iii) groundwater and soil contamination; (iv) the release or threatened release
into the environment of industrial, toxic or hazardous materials or substances,
or solid or hazardous waste, including emissions, discharges, injections,
spills, escapes or dumping of pollutants, contaminants or chemicals; (v) the
protection of wild life, marine life and wetlands, including all endangered and
threatened species; (vi) storage tanks, vessels, containers, abandoned or
discarded barrels and other closed receptacles; (vii) health and safety of
employees and other persons; and (viii) manufacturing, processing, using,
distributing, treating, storing, disposing, transporting or handling of
materials regulated under any law as pollutants, contaminants, toxic or
hazardous materials or substances or oil or petroleum products or solid or
hazardous waste. As used above, the terms. "release" and "environment" shall
have the meaning set forth in the federal Comprehensive Environmental Response,
Compensation and Liability Act of 1980, as amended ("CERCLA").

                  (b) Predix has no liabilities or obligations arising from the
release of any Materials of Environmental Concern (as defined below) into the
environment. For purposes of this Agreement, "Materials of Environmental
Concern" shall mean any chemicals, pollutants or contaminants, hazardous
substances (as such term is defined under CERCLA), solid wastes and hazardous
wastes (as such terms are defined under the Resource Conservation and Recovery
Act), toxic materials, oil or petroleum and petroleum products or any other
material subject to regulation under any Environmental Law.

                  (c) Predix is not a party to or bound by any court order,
administrative order, consent order or other agreement between Predix and any
Governmental Entity entered into in connection with any legal obligation or
liability arising under any Environmental Law.

                  (d) Predix is not aware of any material environmental
liability of any solid or hazardous waste transporter or treatment, storage or
disposal facility that has been used by Predix.

                  (e) Set forth in Exhibit B is a list of all documents (whether
in hard copy or electronic form) that contain any environmental reports,
investigations and audits relating to premises currently or previously owned or
operated by Predix (whether conducted by or on behalf of Predix or a third
party, and whether done at the initiative of Predix or directed by a
Governmental Entity or other third party) which Predix has possession of or
access to. A complete and accurate copy of each such document has been provided
to Physiome.

            3.22 Grants, Incentives and Subsidies. The Company has not had and
does not have Approved Enterprise Status under the Encouragement of Capital
Investments Law 1959, and has not received any funding from the Office of the
Chief Scientist under the Law for the Encouragement of Industrial Research and
Development 1984, the BIRD Foundation, or the Fund for the Encouragement of
Marketing Overseas.

                                     - 14 -

<PAGE>

            3.23 Encryption and Other Restricted Technology. Predix' business as
currently conducted does not involve the use or development of, or engagement
in, encryption technology.

            3.24 Disclosures. Neither this Agreement nor any Exhibit hereto, nor
any Ancillary Agreement nor any report, certificate or instrument furnished to
Physiome or its counsel in connection with the transactions contemplated by this
Agreement, including without limitation the Stockholder Information Statement of
Physiome dated July 1, 2003 (the "Stockholder Information Statement"), when read
together, contains or will contain any untrue statement of a material fact or
omits or will omit to state a material fact necessary in order to make the
statements contained herein or therein, in light of the circumstances under
which they were made, not misleading. Each projection furnished in the
Stockholder Information Statement was prepared in good faith based on reasonable
assumptions and represents Predix' best estimate of future results based on
information available as of the date of the Stockholder Information Statement.

            4. Representations of the Sellers. Each of the Sellers severally
      represents and warrants to Physiome as follows:

            4.1 Share Ownership. The Seller is, or will be as of the Closing
Date, the beneficial and record owner of the Shares set forth opposite such
Seller's name on Exhibit A hereto. There are no other Shares or securities of
Predix to which the Seller is the beneficial owner and the Seller does not own,
control or otherwise have the right to acquire, vote or control any Shares or
other securities of Predix. Except as contemplated by this Agreement and the
Ancillary Agreements, the Seller is not a party to and has no knowledge of any
agreements, written or oral relating to the acquisition, disposition,
registration under the Securities Act, or voting of the securities of Predix
Ltd., Predix Inc. or Physiome. The Seller has good and marketable title to the
Shares, free and clear of all easements, mortgages, pledges, laws, encumbrances,
security interests, equities, charges and restrictions of any nature whatsoever.
By virtue of the deliveries made at Closing, Physiome will obtain good and
marketable title to the Shares, free and clear of all easements, mortgages,
pledges, laws, encumbrances, security interests, equities, charges and
restrictions of any nature whatsoever.

            4.2 Authority of Seller. The Seller has the legal power and
authority to enter into this Agreement, the Ancillary Agreements and the
transactions contemplated herewith and thereby. This Agreement has been, and the
Ancillary Agreements when executed at the Closing will be, duly executed and
delivered by the Seller and constitute valid and binding obligations of the
Seller enforceable in accordance with their respective terms. The execution and
delivery of this Agreement and the Ancillary Agreements, the consummation of the
transactions contemplated hereby and thereby and the compliance with their
respective provisions by the Seller will not (a) in the event the Seller is not
an individual, conflict with or violate any provision of such Seller's governing
documents, (b) require on the part of the Seller any filing with, or any permit,
order, authorization, consent or approval of, any Governmental Entity, (c)
conflict with, result in a breach of, constitute (with or without due notice or
lapse of time or both) a default under, result in the acceleration of
obligations under, create in any party the right to accelerate, terminate,
modify or cancel, or require any notice, consent or waiver under, any contract,
lease, sublease, license, sublicense, franchise, permit, indenture, agreement or
mortgage for borrowed money, instrument of indebtedness, Security Interest or
other arrangement to which

                                     - 15 -

<PAGE>

the Seller is a party or by which the Seller is bound or to which the Seller's
assets are subject, or (d) violate any order, writ, injunction, decree, statute,
rule or regulation applicable to the Seller.

            4.3 Disclosures. None of the information provided by the Seller and
set forth in this Agreement, any Exhibit hereto, any Ancillary Agreement or any
report, certificate or instrument furnished to Physiome or its counsel or its
other representatives in connection with the transactions contemplated by this
Agreement, including without limitation the Stockholder Information Statement,
contains or will contain any untrue statement of a material fact or omits or
will omit to state a material fact necessary in order to make the statements
contained herein or therein, in light of the circumstances under which they were
made, not misleading.

            4.4 Waiver of Claims. Seller, on Seller's own behalf and on behalf
of Seller's successors, predecessors, assigns, agents, attorneys, and all
persons, corporations and other entities which might claim by, through or under
Seller, including, but not limited to, all of Seller's owners, members,
shareholders, partners, employees, officers, directors, agents, attorneys,
representatives successors and assigns, affiliated parties and persons or
entities that have granted proxies to Seller (all of whom are hereinafter
individually and collectively referred to as the "Releasors") hereby (i)
irrevocably and fully releases and forever discharges Predix and Physiome, and
each of their parents, subsidiaries, divisions, related companies, affiliates,
joint ventures, partners, insurers, predecessors, successors, assigns, agents,
servants, employees, officers, directors, trustees, representatives, attorneys,
stockholders and all persons, corporations and other entities which might be
claimed to be jointly or severally liable (the "Releasees") from any and all
claims, complaints, grievances, demands, debts, contracts, agreements,
liabilities, obligations, suits, costs, expenses, rights, actions and causes or
action whatsoever, of whatever nature, character or description, including any
right of rescission, whether known or unknown, whether anticipated or
unanticipated, whether in law or in equity, or whether in the jurisdiction or
any court or regulatory body (collectively, the "Claims") which Releasors now
have, have ever had or may hereafter have against the Releasees relating to or
arising out of Seller's ownership of the Shares; and (ii) agrees and covenants
not to sue or to bring, or assign to any third person, any Claims relating to or
arising out of Seller's ownership of the Shares.

            5. Representations of Physiome. Physiome represents and warrants to
      each of the Sellers as follows:

            5.1 Authority. Physiome has full power and authority to enter into
and to perform this Agreement and the Ancillary Agreements in accordance with
their terms.

            5.2 Experience. Physiome has sufficient knowledge and experience in
finance and business that it is capable of evaluating the risks and merits of
its purchase of the Shares.

            5.3 Board of Directors of Subsidiary. Physiome agrees, after
Closing, to vote its shares in Predix Ltd. and take such actions as shall be
necessary to appoint, as director or directors of Predix Ltd. such person or
persons (which may include one or more corporate entities) all as shall be
determined by Physiome's Board of Directors. The Board of Directors of Predix
Ltd. immediately upon Closing shall consist of Physiome Sciences, Inc. (which
shall be renamed Predix Pharmaceuticals Holdings, Inc. in accordance with the
Delaware General Corporation Law at or prior to the Closing).

                                     - 16 -

<PAGE>

            6. Predix Conduct Prior to Closing and Conditions to Closing;
      Termination.

            6.1 Predix Conduct Prior to Closing. From the date hereof through
and including the earlier of the date of the Closing or the termination of this
Agreement, Predix will operate its business in a manner consistent with prior
practice and will maintain the goodwill of its clients, employees and other
persons with which it has commercial dealings.

      In addition, Predix agrees that, except as otherwise agreed to in writing
by Physiome, from the date hereof through the earlier of the date of the Closing
or the termination of this Agreement:

                  (a) There will not be any increases in salary or other
payments, disbursements or distributions in any manner or form to shareholders,
members, directors, officers, employees or current independent contractors (or
related parties thereto) of Predix or affiliated or related entities, or changes
in the cash or cash equivalent accounts of Predix, other than normal and
necessary transactions in the ordinary course of business of Predix;

                  (b) Revenue and accounts receivable will be maintained on a
normal basis and there will be no changes in methods or procedures for billing,
collection or recording of client accounts receivable relating to the business
of Predix;

                  (c) All normal and recurring installments of bank debt,
leases, contractual obligations and other amounts due third parties, if any,
will be made in the ordinary course of business and as they become due;

                  (d) There will be no new bank debt, leases, loans,
encumbrances, liens, attachments, contractual obligations or other indebtedness,
except in the ordinary course of business, nor openings of new accounts nor
amendments of signatory powers except as agreed by Physiome; and

                  (e) There will not be any hiring of additional employees by
Predix without the express written consent of Physiome, except for the
replacement of terminated employees. If there are any new employees hired by
either party in accordance with the foregoing sentence, such party shall notify
the other party in writing and such notice shall include the name of the
employee and the terms of employment.

            6.2 Conditions to Closing. (a) At or prior to Closing, Predix shall
have provided evidence to Physiome, which evidence must be satisfactory to
Physiome in its sole discretion that:

                        (i) The following Predix agreements will be cancelled as
of Closing: Second Shareholders' Agreement of Predix Ltd. dated May 12, 2003;
Second Registration Rights and Investor Rights Agreements dated May 12, 2003;
Preferred Share Purchase Agreement of Bio-IT Ltd. dated August 29, 2001;
Preferred Share Purchase Agreement of Bio-IT Ltd. dated November 30, 2000;
Preferred Share Purchase Agreement of Bio-IT Ltd. dated October 12, 2000 for
524,686 Series A Shares; and the IPO Option granted to OrbiMed.

                        (ii) Predix shall have received the aggregate loan
amount available under that certain Loan Agreement of Predix Ltd. dated May 12,
2003, and all Convertible Debentures issued pursuant to the Loan Agreement and
all amounts due and owing

                                     - 17 -

<PAGE>

by Predix thereunder at Closing shall be converted into equity at Closing and
such Loan Agreement and all related Convertible Debentures issued pursuant
thereto shall be terminated.

                        (iii) Physiome shall have received an executed
Intellectual Property Assignment Agreement from the Inventors, in the form and
substance attached hereto as Exhibit C, which agreements shall be filed with the
United States Patent and Trademark Office by Physiome subsequent to Closing.

                        (iv) The third party consents, assignments and releases
set forth on Exhibit 6.2(iv) hereto shall be received by Physiome prior to
Closing and all relevant notice periods shall have run prior to Closing.

                        (v) All post-Closing agreements set forth on Exhibit
6.2(v) to be in place with Physiome shall have been fully negotiated to the
satisfaction of each party to each such agreement.

                        (vi) Receipt of: (x) a letter from Ernst and Young LLP
indicating that each of OrbiMed Associates LLC, Caduceus Private Investments,
L.P. and PW Juniper Crossover Fund, L.L.C. (the "OrbiMed Entities") will incur a
capital loss in connection with the sale of their Shares as contemplated by this
Agreement; (y) a written instrument of indemnification from each of the OrbiMed
Entities, in the form attached hereto as Exhibit 6.2(vi), holding Physiome
harmless with respect to any Israeli withholding tax obligation Physiome may be
required to pay to the Israeli Tax Authorities in connection with the
acquisition of such OrbiMed Entity's Shares under this Agreement, and (z) a tax
ruling from the Israeli Tax authorities, in form and substance reasonably
satisfactory to Physiome indicating that no withholding at source is required
under Israeli law with respect to each of Yozma lI (Israel) L.P. and YVC-Yozma
Management and Investments Ltd., as trustee for Yozma H (B.V.I.) L.P.

                  (b) As promptly as practicable after the execution of the
Agreement, Physiome shall use its commercially reasonable efforts to, in
accordance with the Delaware General Corporation Law and Physiome's Certificate
of Incorporation and Bylaws, obtain the approval, by vote or written consent of
Physiome's stockholders (the "Stockholder Approval") for the filing with the
Secretary of State of the State of Delaware of Physiome's Amended and Restated
Certificate of Incorporation, in the form attached hereto as Exhibit D.

                  (c) As of the Closing:

                        (i) No temporary restraining order, preliminary or
permanent injunction or other order (whether temporary, preliminary or
permanent) issued by any court of competent jurisdiction, or other legal
restraint or prohibition shall be in effect which prevents the consummation of
the transactions contemplated by this Agreement, nor shall any proceeding
seeking any of the foregoing be pending.

                        (ii) The representation and warranties of each party to
this Agreement contained herein shall be true and correct in all material
respects, except for those which are qualified as to materiality, which shall be
true and correct in all respects.

                                     - 18 -

<PAGE>

                        (iii) All parties to this Agreement shall have performed
or complied in all respects with all agreements and covenants required to be
performed or complied with by such party by this Agreement.

            6.3 Termination. In the event that: (i) any of the Conditions to
Closing set forth in Section 6.2(a) hereof are not satisfied in full, or waived
by Physiome in its sole discretion; (ii) the Condition to Closing set forth in
Section 6.2(b) hereof is not satisfied in full; (iii) any of the Conditions to
Closing set forth in Section 6.2(c) hereof are not satisfied in full, or waived
by (a) both Physiome and Predix with respect to Section 6.2(c)(i) or (b)
Physiome or Predix, as the case may be with respect to the other party's
representations, warranties, agreements and covenants, with respect to Sections
6.2(c)(ii) and (iii); or (iv) the Sale Agreement is terminated, then all of the
provisions of this Agreement shall terminate and there shall be no liability on
the part of any party hereto; provided, however, the provisions of Section 7.6
shall survive such termination. Notwithstanding anything to the contrary
contained herein, if the Closing does not occur on or before July 31, 2003,
unless such time period is extended by mutual agreement of both Predix and
Physiome, this Agreement shall automatically terminate and shall have no further
force and effect; provided, however, the provisions of Section 7.6 shall survive
such termination. If the Agreement is terminated under this Section 6.3, the
parties shall walk away from this transaction and each party shall bear its own
costs and expenses. Neither party shall have a claim against the other party in
respect with this contemplated transaction and/or the negotiations that have
preceded it.

            7. Miscellaneous.

            7.1 Successors and Assigns. This Agreement, and the rights and
obligations of Physiome hereunder, may be assigned by Physiome to any affiliate,
partner, member, stockholder or subsidiary of Physiome. No Seller may assign
his, her or its rights under this Agreement.

            7.2 Survival of Representations and Warranties. None of the
representations and warranties contained herein shall survive the Closing except
such representations and warranties as set forth in Section 3.1, Section 3.2,
Section 3.3, Section 3.4, Section 3.5, Section 4. 1, Section 4.2, Section 4.4
and Section 5. 1, which representations and warranties shall survive in
perpetuity.

            7.3 Brokers. Except as set forth on Exhibit B hereto, Physiome,
Predix and each Seller: (i) represents and warrants to the other parties hereto
that he, she or it has not retained a finder or broker in connection with the
transactions contemplated by this Agreement; and (ii) will indemnify and save
the other parties harmless from and against any and all claims, liabilities or
obligations with respect to brokerage or finders' fees or commissions, or
consulting fees in connection with the transactions contemplated by this
Agreement asserted by any person on the basis of any statement or representation
alleged to have been made by such indemnifying party.

            7.4 Severability. The invalidity or unenforceability of any
provision of this Agreement shall not affect the validity or enforceability of
any other provision of this Agreement.

                                     - 19 -

<PAGE>

            7.5 Specific Performance. In addition to any and all other remedies
that may be available at law in the event of any breach of this Agreement,
Physiome shall be entitled to specific performance of the agreements and
obligations of Predix and each Seller hereunder and to such other injunctive or
other equitable relief as may be granted by a court of competent jurisdiction.

            7.6 Governing Law; Jurisdiction. This Agreement shall be governed by
and construed in accordance with the internal laws of the State of Delaware
(without reference to the conflicts of law provisions thereof), except for
matters related to the internal corporate governance of Predix Ltd., including
the mechanics and procedures relating to the transfer of the Shares, which shall
be governed by the laws of the State of Israel. Each of the parties hereto (a)
submits to the jurisdiction of any state or United States federal court sitting
in the State of Delaware in any action or proceeding arising out of or relating
to this Agreement (including any action or proceeding for the enforcement of any
arbitral award made in connection with any arbitration of a dispute hereunder),
(b) agrees that all claims in respect of such action or proceeding may be heard
and determined in any such court, (c) waives any claim of inconvenient forum or
other challenge to venue in such court, (d) agrees not to bring any action or
proceeding arising out of or relating to this Agreement in any other court and
(e) waives any right it may have to a trial by jury with respect to any action
or proceeding arising out of or relating to this Agreement. Each Party agrees to
accept service of any summons, complaint or other initial pleading made in the
manner provided for the giving of notices in Section 7.7, provided that nothing
in this Section 7.6 shall affect the right of any party to serve such summons,
complaint or other initial pleading in any other manner permitted by law

            7.7 Notices. All notices, requests, consents, and other
communications under this Agreement shall be in writing and shall be deemed
delivered (i) seven business days after being sent by registered or certified
mail, return receipt requested, postage prepaid or (ii) three business day after
being sent via a reputable international overnight courier service guaranteeing
next business day delivery, in each case to the intended recipient as set forth
below:

      If to Physiome, at 150 College Road West, Suite 300, Princeton, New Jersey
08540-6604, Attention: Chief Operating Officer, or at such other address as may
have been furnished in writing by Physiome to the other parties hereto, with a
copy to Hale and Dorr LLP, 650 College Road East, 4th Floor, Princeton, New
Jersey 08540, Attention: Richard S. Mattessich, Esq.; or

      If to Predix, at 10 K Gill Street, Woburn, Massachusetts 01801, Attention:
Chief Executive Officer, or at such other address as may have been furnished in
writing by Predix to the other parties hereto, with copies to Mintz, Levin,
Cohn, Ferris, Glovsky and Popeo, P.C., One Financial Center, Boston,
Massachusetts 02111, Attention: John R. Pomerance, Esq. and Volovelsky,
Dinstein, Sneh & Co., Law Offices, Nolton House, 14 Shenkar Street, P.O. Box
12172, Herzliya-Pituach 46733, Israel, Attention: Nehama Sneh, Advocate; or

      If to a Seller, at its address set forth on Exhibit A, or at such other
address as may have been furnished in writing by such Seller to the other
parties hereto, with a copy to such Seller's counsel, if any, as such Seller
shall have notified Physiome, in writing.

      Any party may give any notice, request, consent or other communication
under this Agreement using any other means (including, without limitation,
personal delivery, messenger service, telecopy, first class mail or electronic
mail), but no such notice, request, consent or other

                                     - 20 -

<PAGE>

      communication shall be deemed to have been duly given unless and until it
is actually received by the party for whom it is intended. Any party may change
the address to which notices, requests, consents or other communications
hereunder are to be delivered by giving the other parties notice in the manner
set forth in this Section.

            7.8 Complete Agreement. This Agreement (including its Exhibits)
constitutes the entire agreement and understanding of the parties hereto with
respect to the subject matter hereof and supersedes all prior agreements and
understandings relating to such subject matter including, without limitation,
that certain letter of intent dated April 25, 2003.

            7.9 Amendments and Waivers. This Agreement may be amended or
terminated and the observance of any term of this Agreement may be waived with
respect to all parties to this Agreement (either generally or in a particular
instance and either retroactively or prospectively), with the written consent of
Physiome and the holders of at least 75% of the Shares sold by the Sellers
hereunder. Notwithstanding the foregoing, this Agreement may not be amended or
terminated and the observance of any term hereunder may not be waived with
respect to any Seller without the written consent of such Seller unless such
amendment, termination or waiver applies to all Sellers in the same fashion.
Physiome shall give prompt written notice of any amendment or termination hereof
or waiver hereunder to any party hereto that did not consent in writing to such
amendment, termination or waiver. Any amendment, termination or waiver effected
in accordance with this Section 7.9 shall be binding on all parties hereto, even
if they do not execute such consent. No waivers of or exceptions to any term,
condition or provision of this Agreement, in any one or more instances, shall be
deemed to be, or construed as, a further or continuing waiver of any such term,
condition or provision.

            7.10 Required Disclosures. Each party hereto (and each employee,
representative, or other agent of such party) may disclose to any and all
persons, without limitation of any kind, the United States federal tax treatment
and tax structure of the transactions contemplated hereby and all materials of
any kind (including opinions or other tax analyses) that are provided to it
relating to such tax treatment and tax structure. For this purpose, 'tax
structure' is limited to any facts relevant to the United States federal income
tax treatment of the transaction and does not include information relating to
the identity of the parties.

            7.11 Pronouns. Whenever the context may require, any pronouns used
in this Agreement shall include the corresponding masculine, feminine or neuter
forms, and the singular form of nouns and pronouns shall include the plural, and
vice versa.

            7.12 Counterparts; Facsimile Signatures. This Agreement may be
executed in any number of counterparts, each of which shall be deemed to be an
original, and all of which shall constitute one and the same document. This
Agreement may be executed by facsimile signatures.

            7.13 Section Headings and References. The section headings are for
the convenience of the parties and in no way alter, modify, amend, limit or
restrict the contractual obligations of the parties. Any reference in this
agreement to a particular section or subsection shall refer to a section or
subsection of this Agreement, unless specified otherwise.

                                  ** ** ** **

                                     - 21 -

<PAGE>

Executed as of the date first written above.

                               PHYSIOME SCIENCES, INC.

                               By: /s/ NIK HAYES
                                   ---------------------------------------------
                                   Name: Mr. Nik Hayes
                                   Title: Chief Operating Officer
                                          and Chief Financial Officer

                               PREDIX PHARMACEUTICALS, LTD.

                               By: /s/ MICHAEL KAUFFMAN MD
                                   ---------------------------------------------
                                   Name: Dr. Michael Kauffman
                                   Title: President and Chief Executive Officer

                               PREDIX PHARMACEUTICALS, INC.

                               By: /s/ MICHAEL KAUFFMAN MD
                                   ---------------------------------------------
                                   Name: Dr. Michael Kauffman
                                   Title: President and Chief Executive Officer

                               STOCKHOLDERS OF
                                        PREDIX PHARMACEUTICALS, LTD.

                               /s/ ILLEGIBLE
                               ------------------------------------------------
                               Dr. Oren Becker, by YVC Yozma as proxy holder

                               /s/ ILLEGIBLE
                               ------------------------------------------------
                               Zvi Naor, by YVC Yozma as proxy holder

                               /s/ ILLEGIBLE
                               ------------------------------------------------
                               Dr. Silvia Noiman, by YVC Yozma as proxy holder

                               /s/ HAIM AVIV
                               ------------------------------------------------
                               Prof. Haim Aviv

<PAGE>

                                    /s/ FREDERICK FRANK
                                    --------------------------------------------
                                    Frederick Frank

                                    RAMOT AT TEL AVIV UNIVERSITY LTD.

                                    By: /s/ ILLEGIBLE
                                        ----------------------------------------
                                        By YVC Yozma Management and Investment
                                        LTD as proxy holder

                                    YOZMA II (ISRAEL) LP

                                    By: /s/ ILLEGIBLE
                                        ---------------------------------------
                                        Name:  Yigal Erlich & Chen Schor
                                        Title: Partners

                                    YVC YOZMA MANAGEMENT AND INVESTMENT
                                    LTD., as trustees for YOZMA II (BVI) LP

                                    By: /s/ ILLEGIBLE
                                        ---------------------------------------
                                        Name:  Yigal Erlich & Chen Schor
                                        Title: Partners

                                    PCM VENTURE CAPITAL L.P.

                                    By: /s/ ILLEGIBLE
                                        ---------------------------------------
                                        Name:  Yigal Erlich & Chen Schor
                                        Title: Partners

                                    ORBIMED ASSOCIATES LLC

                                    By: /s/ JONATHAN SILVERSTEIN
                                        ----------------------------------------
                                        Name:  Jonathan Silverstein
                                        Title: Partner

<PAGE>

                                    CADUCEUS PRIVATE INVESTMENTS LP

                                     By: /s/ JONATHAN SILVERSTEIN
                                         ------------------------
                                         Name:  Jonathan Silverstein
                                         Title: Partner

                                    PW JUNIPER CROSSOVER FUND LLC

                                    By: /s/ JONATHAN SILVERSTEIN
                                        ------------------------
                                        Name:  Jonathan Silverstein
                                        Title: Partner

<PAGE>

                                    EXHIBIT A

                         LIST OF SELLERS AND SHARES SOLD

<TABLE>
<CAPTION>
                                                                         AGGREGATE  AGGREGATE
                                                                         SHARES OF  SHARES OF  AGGREGATE   MAXIMUM
                                                                          PHYSIOME  PHYSIOME   SHARES OF  AGGREGATE    AGGREGATE
                                                            EQUIVALENT    SERIES B  SERIES A    PHYSIOME  NUMBER OF     PERCENT
                                    NO. OF       NO. OF        CASH      PREFERRED  PREFERRED    COMMON  TRANSACTION  OF FUNDING
                                  PREFERRED     ORDINARY     PURCHASE      STOCK      STOCK      STOCK     WARRANTS    WARRANTS
  NAME AND ADDRESS OF SELLER     SHARES SOLD  SHARES SOLD     PRICE      PURCHASED  PURCHASED  PURCHASED  PURCHASED   PURCHASED(1/)
-------------------------------  -----------  -----------  ------------  ---------  ---------  --------- -----------  ------------
<S>                              <C>          <C>          <C>           <C>        <C>        <C>       <C>          <C>
Dr. Oren Becker................           --       24,000  $     14,692         --         --     14,692          --            --
Ramot at Tel Aviv University
    Ltd. ......................           --       24,000  $     14,692         --         --     14,692          --            --
Zvi Naor.......................           --        4,000  $      2,448         --         --      2,448          --            --
Dr. Silvia Noiman..............           --       24,000  $     14,692         --         --     14,692          --            --
Prof. Haim Aviv................           --       24,000  $     14,692         --         --     14,692         '--            --
Yozma II (Israel) LP...........    1,610,158           --  $    772,110     17,508     59,703         --      30,491          3.05%
YVC-Yozma Management and
    Investment Ltd., as
    trustees for Yozma II
    (BVI) LP...................    2,744,594           --  $  1,316,110     29,844    101,767         --      51,974          5.20%
PCM Venture Capital L.P. ......    1,463,786           --  $    701,930     15,917     54,276         --      27,719          2.77%
OrbiMed Associates LLC.........      176,636           --  $     84,690      1,920      6,549         --       3,344          0.33%
Caduceus Private
   Investments LP..............    7,254,111           --  $  3,478,570     78,880    268,977         --     137,372         13.74%
Frederick Frank................      121,556           --  $     58,280      1,321      4,507         --       2,301          0.23%
PW Juniper Crossover
   Fund LLC....................    2,471,433           --  $  1,185,130     26,874     91,639         --      46,801          4.68%
                                 -----------  -----------  ------------  ---------  ---------  --------- -----------  ------------
          Total                   15,842,274      100,000  $  7,658,036    172,264    587,418     61,216     300,002          30.0%
                                 ===========  ===========  ============  =========  =========  ========= ===========  ============
</TABLE>

--------------
(1/) Represents pro-rata portion of calculation done on date of closing.

<PAGE>

                                   EXHIBIT A1

                                     OPTIONS

<TABLE>
<CAPTION>
         NAME OF OPTIONEE                    NUMBER OF PHYSIOME OPTIONS RECEIVED
--------------------------------------       -----------------------------------
<S>                                          <C>
Oren Becker...........................                     339,114
Dr. Silvia Noiman.....................                      339114
Haim Aviv (SAB member)................                     131,349
Charles Homcy (Director)..............                       9,017
Michael Kauffman......................                     757,022
Dale Dhanoa...........................                     192,258
Sharon Schcham........................                      42,992
Yael Marantz..........................                      30,339
Shay Bar-Haim.........................                      16,046
Liora Ben-Ari.........................                      12,697
Ayelet Aharon.........................                      10,544
Meirav Vichman........................                      10,544
Ori Kalid.............................                      13,069
Boaz Inbal............................                      14,002
Alexander Heifetz.....................                      12,455
Raphael Nudelman......................                      13,069
Harel Weinstein (SAB member)..........                       4,046
Michael Levit (SAB member)............                       4,046
Ehud Landau (SAB member)..............                       4,046
Martin Karplus (SAB member)...........                       4,046
Carl Johnson (SAB member).............                       4,046
Dougli Chen...........................                      13,147
Mohanty K. Pradyumna..................                      10,697
Anurag Scharadendu....................                      10,697
Christin Wang.........................                      30,000
Srinivasa Cheruku.....................                      13,147
Nick Leschly..........................                         137
</TABLE>

<PAGE>

                                    EXHIBIT C

                   INTELLECTUAL PROPERTY ASSIGNMENT AGREEMENT

                                   ASSIGNMENT

      WHEREAS, we, [INVENTORS' NAMES], employed by Predix Pharmaceuticals, Ltd.
or Predix Pharmaceuticals, Inc., are the inventors of certain new and useful
inventions and discoveries, for which application for Letters Patent entitled
[TITLE] was filed with the United States Patent and Trademark Office as U.S.
Application Serial No. _______________ on _________; and

      WHEREAS, Predix Pharmaceuticals, Inc., together with its successors and
assigns is hereinafter called "ASSIGNEE," is desirous of acquiring the title,
rights, benefits, and privileges hereinafter recited;

      NOW, THEREFORE, for good and valuable consideration furnished by ASSIGNEE
to us, receipt and sufficiency of which we hereby acknowledge, we hereby,
without reservations:

      1. Assign, transfer, and convey to ASSIGNEE our entire right, title, and
interest in and to said inventions and discoveries, said applications for
Letters Patent, any and all other applications for Letters Patent on said
inventions and discoveries in whatsoever countries, including all provisional,
nonprovisional, divisional, renewal, substitute, continuation,
continuation-in-part, continued prosecution applications, and convention
applications based in whole, or in part, upon said inventions or discoveries, or
upon said applications, and any and all Letters Patents, reissues,
reexaminations, and extensions of Letters Patent granted for said inventions and
discoveries or upon said applications, and every priority right that is or may
be predicated upon, or arise from, said inventions, said discoveries, said
applications, and said Letters Patent;

      2. Authorize ASSIGNEE to file patent applications in any or all countries
on any or all of said inventions and discoveries in my name or in the name of
ASSIGNEE or otherwise as ASSIGNEE may deem advisable, under International
Conventions or otherwise;

      3. Authorize and request the Commissioner of Patents and Trademarks of the
United States of America and the empowered officials of all other governments
throughout the world to issue or transfer all said Letters Patents to ASSIGNEE,
as assignee of the entire right, title, and interest therein or otherwise as
ASSIGNEE may direct;

      4. Warrant that we have not knowingly conveyed to others any right in said
inventions, discoveries, applications, or patents, or any license to use the
same, or to make, use, or sell anything embodying or utilizing any of said
inventions or discoveries; and that we have good right to assign the same to
ASSIGNEE without encumbrance;

      5. Bind our heirs, legal representatives, and assigns, as well as
ourselves, to do, upon ASSIGNEE's request and at ASSIGNEE's expense, but without
additional consideration to us or them, all acts reasonably serving to assure
that said inventions and discoveries, said patent

<PAGE>

applications, and said Letters Patents shall be held and enjoyed by ASSIGNEE as
fully and entirely as the same could have been held and enjoyed by us, our
heirs, legal representatives, and assigns if this Assignment had not been made;
and particularly to execute and deliver to ASSIGNEE all lawful application
documents including petitions, specifications, and oaths, and all assignments,
disclaimers, and lawful affidavits in form and substance as may be requested by
ASSIGNEE; and to communicate to ASSIGNEE all facts known to us relating to said
inventions and discoveries or the history thereof, and to testify as to the same
in any court or proceeding; and to furnish ASSIGNEE any and all documents,
photographs, models, samples, and other physical exhibits in my control or in
the control of our heirs, legal representatives, or assigns which may be useful
for establishing the facts of my conceptions, disclosures, and reduction to
practice of said inventions and discoveries.

      IN TESTIMONY WHEREOF, we have hereunto set our hand and seal.

Date: ______________________________                       Signature of Inventor

                                                           _____________________
INVENTOR'S NAME

Witness printed name: __________________________________
Witness signature: _____________________________________
Witness address: _______________________________________

Date: ______________________________                       Signature of Inventor

                                                           _____________________
INVENTOR'S NAME

Witness printed name: __________________________________
Witness signature: _____________________________________
Witness address: _______________________________________
<PAGE>

                                    EXHIBIT D
          FORM OF AMENDED AND RESTATED CERTIFICATE OF INCORPORATION OF
                             PHYSIOME SCIENCES, INC.

<PAGE>

                AMENDED AND RESTATED CERTIFICATE OF INCORPORATION
                                       OF
                             PHYSIOME SCIENCES, INC.

      Physiome Sciences, Inc., a corporation organized and existing under the
laws of the State of Delaware (hereinafter referred to as the "Corporation"),
hereby certifies as follows:

      1.    The name of the Corporation is Physiome Sciences, Inc. The
Corporation was originally incorporated under the game Takhus Pharmaceuticals,
Inc. and filed its original certificate of incorporation with the Secretary of
State of the State of Delaware on November 2, 1994.

      2.    This Amended and Restated Certificate of Incorporation amends and
restates in its entirety the Corporation's certificate of incorporation, as
amended and restated from time to time, to amend, among other things, the
following to: (i) change its name to Predix Pharmaceuticals Holdings, Inc.; (ii)
provide for a one-for-17.971067 reverse stock split of the Corporation's
Existing Common Stock; (iii) create a new class of Class A Common Stock; (iv)
reclassify and convert the outstanding shares of the Corporation's Series A
Convertible Preferred Stock, Series B Convertible Preferred Stock and Series C
Convertible Preferred Stock into shares of a newly created class of Series A
Convertible Preferred Stock and delete all references to such prior preferred
classes; (v) reclassify and convert the outstanding shares of the Corporation's
Series D Convertible Preferred Stock into shares of a newly created class of
Series B Convertible Preferred Stock and delete all references to such prior
preferred class; and (vi) designate the newly created Series A Convertible
Preferred Stock and Series B Convertible Preferred Stock as set forth below.

      3.    This Amended end Restated Certificate of Incorporation was duly
adopted in accordance with the provisions of Sections 228, 242 and 245 of the
General Corporation Law of the State of Delaware, the requisite written consent
of the holders of each class of stock entitled to vote thereon has been voted in
favor of this Amended and Restated Certificate of Incorporation and written
notice has been given as provided by Section 228 of the General Corporation Law
of the State of Delaware. This Amended and Restated Certificate of Incorporation
(referred to hereinafter as the "Certificate of Incorporation") restates,
integrates and further amends the provisions of the Corporation's certificate of
incorporation, as amended to date (including all certificates of designation),
as follows:

      FIRST. The name of the corporation is Predix Pharmaceuticals Holdings,
Inc. (the "Corporation").

      SECOND. The address of the Corporation's registered office in the State of
Delaware is Corporation Service Company, 2711 Centerville Road, Suite 400, in
the City of Wilmington, County of New Castle, Delaware, 19808. The name of its
registered agent at such address is the Corporation Service Company.

                                       1
<PAGE>

      THIRD. The nature of the business or purposes to be conducted or promoted
by the Corporation is as follows:

      To engage in any lawful act or activity for which corporations may be
organized under the General Corporation Law of the state of Delaware (the
"DGCL").

      FOURTH. Upon this Amended and Restated Certificate of Incorporation
becoming effective pursuant to the DGCL (the "Effective Time"), a
one-for-17.971067 reverse stock split of the Corporation's Common Stock, $.01
par value per share (the "Existing Common Stock"), shall become effective,
pursuant to which each share of the Corporation's Existing Common Stock issued
and outstanding and held of record by each stockholder of the Corporation
(including treasury shares) immediately prior to the Effective Time shall be
reclassified and converted into 0.055645 fully paid and nonassessable shares of
the Corporation's Common Stock, $.01 par value per share (the "New Common
Stock"), automatically and without any action by the holder thereof upon the
Effective Time. Any stock certificate that, immediately prior to the Effective
Time, represented shares of the Corporation's Existing Common Stock shall
automatically and without the necessity of presenting the same for exchange,
represent 0.055645 shares of the Corporation's New Common Stock from and after
the Effective Time for each share of Existing Common Stock outstanding
immediately prior to the Effective Time and represented by such certificate. No
fractional shares of New Common Stock shall be issued as a result of such
reclassification and conversion. In lieu of any fractional shares to which the
stockholder would otherwise be entitled, the Corporation shall pay cash equal to
such fraction multiplied by the then fair market value of the Corporation's New
Common Stock as determined by the Board of Directors of &a Corporation.

      Upon the Effective Time, each share of the Corporation's Series A
Convertible Preferred Stock, $.01 par value per share (the "Existing Series A
Preferred Stock"), issued and outstanding or held in treasury of the Corporation
is hereby reclassified and converted (irrespective of any accrued dividends or
adjustments to the conversion price of the Existing Series A Preferred Stock)
into 0.022104 fully paid and nonassessable shares of the Corporation's New
Series A Preferred Stock, as defined in Article FIFTH, automatically and without
any action by the holder thereof upon the Effective Time and all accrued and
unpaid dividends thereon, if any, shall be cancelled. Any stock certificate
that, immediately prior to the Effective Time, represented shares of the
Corporation's Existing Series A Preferred Stock shall, automatically and without
the necessity of presenting the same for exchange, represent 0.022104 shares of
the Corporation's New Series A Preferred Stock from and after the Effective Time
for each share of Existing Series A Preferred Stock outstanding immediately
prior to the Effective Time and represented by such certificate. No fractional
shares of New Series A Preferred Stock shall be issued as a result of such
reclassification and conversion. In lieu of any fractional shares to which the
stockholder would otherwise be entitled, the Corporation shall pay cash equal to
such fraction multiplied by the then fair market value of the Corporation's New
Series A Preferred Stock as determined by the Board of Directors of the
Corporation.

      Upon the Effective Time, each share of the Corporation's Series B
Convertible Preferred Stock, $.01 par value per share (the "Existing Series B
Preferred Stock"), issued and outstanding or held in treasury of the Corporation
is hereby reclassified and converted (irrespective of any accrued dividends or
adjustments to the conversion price of the Existing Series B Preferred

                                      -2-
<PAGE>

      Stock) into 0.035661 fully paid and nonassessable shares of the
Corporation's New Series A Preferred Stock automatically and without any action
by the holder thereof upon the Effective Time and all accrued and unpaid
dividends thereon, if any, shall be cancelled. Any stock certificate that,
immediately prior to the Effective Time, represented shares of the Corporation's
Existing Series B Preferred Stock shall, automatically and without the necessity
of presenting the same for exchange, represent 0.035661 shares of the
Corporation's New Series A Preferred Stock from and after the Effective Time for
each share of Existing Series B Preferred Stock outstanding immediately prior to
the Effective Time and represented by such certificate. No fractional shares of
New Series A Preferred Stock shall be issued as a result of such
reclassification and conversion. In lieu of any fractional shares to which the
stockholder would otherwise be entitled, the Corporation shall pay cash equal to
such fraction multiplied by the then fair market value of the Corporation's New
Series A Preferred Stock as determined by the Board of Directors of the
Corporation

      Upon the Effective Time, each share of the Corporation's Series C
Convertible Preferred Stock, $.01 par value per share (the "Series C Preferred
Stock"), issued and outstanding or held in treasury of the Corporation is hereby
reclassified and converted (irrespective of any accrued dividends or adjustments
to the conversion price of the Series C Preferred Stock) into 0.084149 fully
paid and nonassessable shares of the Corporation's New Series A Preferred Stock
automatically and without any action by the holder thereof upon the Effective
Time and all accrued and unpaid dividends thereon, if any, shall be cancelled.
Any stock certificate that, immediately prior to the Effective Time, represented
shares of the Corporation's Series C Preferred Stock stall, automatically and
without the necessity of presenting the same for exchange, represent 0.084149
shares of the Corporation's New Series A Preferred Stock from and after the
Effective Time for each share of Series C Preferred Stock outstanding
immediately prior to the Effective Time and represented by such certificate. No
fractional shares of New Series A Preferred Stock shall be issued as a result of
such reclassification and conversion. In lieu of any fractional shares to which
the stockholder would otherwise be entitled, the Corporation shall pay cash
equal to such fraction multiplied by the then fair market value of the
Corporation's New Series A Preferred Stock as determined by the Board of
Directors of the Corporation.

      Upon the Effective Time, each share of the Corporation's Series D
Convertible Preferred Stock, $.01 par value per share (the "Series D Preferred
Stock"), issued and outstanding or held in treasury of the Corporation is hereby
reclassified and converted (irrespective of any accrued dividends or adjustments
to the conversion price of the Series D Preferred Stock) into 0.123774 fully
paid and nonassessable shares of the Corporation's New Series B Preferred Stock,
as defined in Article FIFTH, automatically and without any action by the holder
thereof upon the Effective Time and all accrued and unpaid dividends thereon, if
any, shall be cancelled. Any stock certificate that, immediately prior to the
Effective Time, represented shares of the Corporation's Series D Preferred Stock
shall, automatically and without the necessity of presenting the same for
exchange, represent 0.123774 shares of the Corporation's New Series B Preferred
Stock from and after the Effective Time for each share of Series D Preferred
Stock outstanding immediately prior to the Effective Time and represented by
such certificate. No fractional shares of New Series B Preferred Stock shall be
issued as a result of such reclassification and conversion. In lieu of any
fractional shares to which the stockholder would otherwise be entitled, the
Corporation shall pay cash equal to such fraction multiplied by the then

                                      -3-
<PAGE>

      fair market value of the Corporation's New Series B Preferred Stock as
determined by the Board of Directors of the Corporation.

      FIFTH. The total number of shares of all classes of stock which the
Corporation shall have authority to issue is forty eight million (48,000,000)
shares, consisting of: (i) forty million (40,000,000) shares of New Common
Stock; (ii) four million four hundred thousand (4,400,000) shares of Class A
Common Stock, $0.01 par value per share (the "Class A Common Stock"); (iii) one
million one hundred thousand (1,100,000) shares of Series A Convertible
Preferred Stock, $0.01 par value per share (the "New Series A Preferred Stock"
or the "Series A Preferred Stock"); and (iv) two million five hundred thousand
(2,500,000) shares of Series B Convertible Preferred Stock, $0.01 per value per
share (the "New Series B Preferred Stock" or the "Series B Preferred Stock").
The Series A Preferred. Stock and the Series B Preferred Stock are sometimes
referred to herein as the "Designated Preferred Stock". The New Common Stock and
the Class A Common Stock are sometimes referred to herein as the "Common Stock".

      The following is a statement of the designations and the powers,
privileges and rights, and the qualifications, limitations or restrictions
thereof in respect of each class of capital stock of the Corporation.

A.    COMMON STOCK

      1.    Dividends. The holders of Common Stock, subject to the preferential
rights of the holders of any of the then outstanding Series A Preferred Stock,
Series B Preferred Stock and any other class or series of shares ranking (as to
dividends) senior to the Common Stock, shall be entitled to receive dividends
and the Corporation shall pay dividends thereon, as, if and when declared by the
Board of Directors of the Corporation out of funds legally available for the
payment of dividends, in such amount and in such form as the Board of Directors
may from time to time determine. All dividends which the Board of Directors may
declare on the New Common Stock shall be declared and paid in equal amounts per
share on all New Common Stock at the time outstanding, All dividends which the
Board of Directors may declare on the Class A Common Stock shall be declared and
paid in equal amounts per share on all Class A Common Stock at the time
outstanding.

      2.    Liquidation. In the event of the liquidation, dissolution or winding
up of the Corporation, either voluntary or involuntary, or other distribution of
assets of the Corporation among its stockholders for the purpose of winding up
its affairs, pursuant to applicable law, the holders of the Common Stock,
subject to the preferential rights of any of the holders of the then outstanding
Series A Preferred Stock, Series B Preferred Stock and any other class or series
of stock ranking on liquidation, dissolution or winding up senior to the Common
Stock, and except as may otherwise be provided pursuant to Section B.2 below,
shall be entitled to receive all the assets of the Corporation available for
distribution to its stockholders. Such distributions shall be paid in equal
amounts per share on all Common Stock at the time outstanding. Notwithstanding
the foregoing, the New Common Stock shall have such preferential rights over the
Class A Common Stock in the event of any liquidation, dissolution or winding up
of the Corporation or other distribution of Assets of the Corporation among its
stockholders for the purposes of winding up its affairs as set forth herein.

                                      -4-
<PAGE>

      3.    Voting. The holders of Common Stock shall be entitled to receive
notice of and to attend all meetings of the stockholders of the Corporation and
shall have one vote for each share of Common Stock held at all meetings of the
stockholders of the Corporation, except for meetings at which only holders of
another specified class or series of shares of the Corporation are entitled to
vote separately as a class or series.

B.    SERIES A CONVERTIBLE PREFERRED STOCK AND SERIES B CONVERTIBLE PREFERRED
      STOCK

      1.    Dividends.

            (a)   The Corporation shall not declare, pay or set aside any
dividends (other than dividends payable in shares of New Common Stock) on Common
Stock unless the holders of the Series A Preferred Stock and Series B Preferred
Stock then outstanding shall first receive, or simultaneously receive, a
dividend on each outstanding share of Series A Preferred Stock and Series B
Preferred Stock equal to the product of (i) the per share dividend to be
declared, paid or set aside for the Common Stock multiplied by (ii) the number
of shares of New Common Stock into which each share of Series A Preferred Stock
or Series B Preferred Stock is then convertible.

            (b)   In the event that there shall be declared but unpaid dividends
outstanding with respect to the Series A Preferred Stock or Series B Preferred
Stock immediately prior to, and in the event of, a conversion of any shares of
Series A Preferred Stock or Series B Preferred Stock as provided in Section 4
hereof, the Corporation shall, at the option of each holder of such shares, pay
in cash, out of funds legally available therefor, to each such holder the full
amount of any such dividends or, unless registration or qualification of such
New Common Stock would be required under applicable securities laws, allow such
dividends to be converted into New Common Stock in accordance with, and pursuant
to the terms specified in, Section 4 hereof.

      2.    Liquidation, Dissolution or Winding Up; Certain Mergers,
Consolidations and Asset Sales

            (a)   Liquidation. In the event of any liquidation, dissolution or
winding up of the Corporation, either voluntary or involuntary, or other
distribution of assets of the Corporation among its stockholders for the purpose
of winding up its affairs, pursuant to applicable law, all the assets of the
Corporation available for distribution among the stockholders shall be
distributed to them in the following order and preference:

                  (i)   First, each holder of Series B Preferred Stock shall be
entitled to receive, prior and in preference to any distribution of any of the
assets of the Corporation to any other stockholders by reason of their ownership
thereof, an amount equal to the Series B Conversion Price (as defined in Section
4 below) (as adjusted to reflect stock splits, stock dividends,
recapitalizations and similar transactions) for each outstanding share of Series
B Preferred Stock held by such stockholder (the "Preferred B Preference"). If
upon the occurrence of such event, the assets and funds thus distributed among
the holders of the Series B Preferred Stock shall be insufficient to permit the
payment to such holders of the full Preferred B Preference, then the entire
assets and funds of the Corporation legally available for distribution

                                      -5-
<PAGE>

                  shall be distributed ratably among the holders of the Series B
Preferred Stock in proportion to the amount of such stock owned by each such
holder.

                  (ii)  Second, following payment of the Preferred B Preference,
each holder of Series A Preferred Stock shall be entitled to receive, prior and
in preference to any distribution of any of the assets of the Corporation to any
other stockholders by reason of their ownership thereof, an amount equal to the
Series A Conversion Price (as defined in Section 4 below) (as adjusted to
reflect stock splits, stock dividends, recapitalizations and similar
transactions) for each outstanding share of Series A Preferred Stock held by
such stockholder (the "Preferred A Preference"). If upon the occurrence of such
event, the assets and funds thus distributed among the holders of the Series A
Preferred Stock shall be insufficient to permit the payment to such holders of
the full Preferred A Preference, then the entire remaining assets and funds of
the Corporation legally available for distribution shall be distributed ratably
among the holders of the Series A Preferred Stock in proportion to the amount of
such stock owned by each such holder.

                  (iii) Third, following payment of the Preferred A Preference,
                        each holder of New Common Stock shall be entitled to
receive, prior and in preference to any distribution of any of the assets of the
Corporation to any other stockholders by reason of their ownership thereof, an
amount equal to $1.00 (as adjusted to reflect stock splits, stock dividends,
recapitalizations and similar transactions) for each outstanding share of New
Common Stock held by such stockholder (the "New Common Preference"). If upon the
occurrence of such event, the assets and funds thus distributed among the
holders of the New Common Stock shall be insufficient to permit the payment to
such holders of the full New Common Preference, then the entire remaining assets
and funds of the Corporation legally available for distribution shall be
distributed ratably among the holders of the New Common Stock in proportion to
the amount of such stock owned by each such holder.

                  (iv)  Fourth, after payment of the Preferred B Preference,
Preferred A Preference and New Common Preference, the entire remaining assets
and funds of the Corporation legally available for distribution, if any, shall
be distributed pro rata among all holders of the Series B Preferred Stock,
Series A Preferred Stock and Common Stock (treating all holders of Series B
Preferred Stock and Series A Preferred Stock as holders of Common Stock on an
as-converted to New Common Stock basis).

            (b)   Other Liquidation Events (Cash Consideration Only). In the
event of (i) a merger or consolidation of the Corporation with or into another
entity (except if such merger or consolidation does not result in the transfer
of more than 50% by voting power of the outstanding capital stock of the
Corporation or in which the holders of 50% or more by voting power of the
outstanding capital stock of the Corporation immediately prior to such
transaction continue, by virtue of their holdings of securities of the
Corporation, to hold 50% or more by voting power of the outstanding capital
stock of the surviving corporation immediately after the transaction); or (ii)
the sale, in a single transaction or series of related transactions, by the
Corporation of all or substantially all the assets of the Corporation (except
where such sale is to a wholly-owned subsidiary of the Corporation) (such events
described in Section 2(b)(i) and Section 2(b)(ii) referred to as "Deemed
Liquidation Events"), pursuant to which the consideration in connection with
such Deemed Liquidation Events is paid solely in cash, such consideration, less
any

                                      -6-
<PAGE>

            obligations of the Corporation not specifically assumed in writing
by the potential acquiror under the terms of the contemplated transaction, shall
be distributed among the Corporation's stockholders in the following order and
preference:

                  (A)   First, each holder of Series B Preferred Stock shall be
entitled to receive, prior and in preference to any distribution of any of the
funds of the Corporation to any other stockholders by reason of their ownership
thereof, an amount equal to the Preferred B Preference for each outstanding
share of Series B Preferred Stock held by such stockholder. If upon the
occurrence of such event, the funds thus distributed among the holders of the
Series B Preferred Stock shall be insufficient to permit the payment to such
holders of the full Preferred B Preference, then such consideration less any
required obligations of the Corporation shall be distributed ratably among the
holders of the Series B Preferred Stock in proportion to the amount of such
stock owned by each such holder.

                  (B)   Second, following payment of the Preferred B Preference
pursuant to Section 2(b)(A), the holders of Series A Preferred Stock and New
Common Stock shall be entitled to receive, prior and in preference to any
distribution of any of the funds of the Corporation to any other stockholders by
reason of their ownership thereof, an amount equal to the New Common Preference
(treating all holders of Series A Preferred Stock on an as-converted to New
Common Stock basis). If upon the occurrence of such event, the funds thus
distributed among the holders of the Series A Preferred Stock (on an
as-converted to New Common Stock basis) and New Common Stock shall be
insufficient to permit the full payment of the New Common Preference to such
holders, then such consideration less any required obligations of the
Corporation shall be distributed ratably among the holders of the Series A
Preferred Stock and New Common Stock in proportion to the amount of such stock
owned by each holder, on an as-converted to New Common Stock basis.

                  (C)   Third, after the payments set forth in Section 2(b)(A)
and Section 2(b)(B) above, the entire remaining consideration, if any, shall be
distributed pro rata among all holders of the Series B Preferred Stock, Series A
Preferred Stock and Common Stock (treating all holders of Series B Preferred
Stock and Series A Preferred Stock as holders of Common Stock on an as-converted
to New Common Stock basis).

            (c)   Other Liquidation Events (Including Non-Cash Consideration).
In the event of a Deemed Liquidation Event pursuant to which the consideration
to the Corporation in connection with such Deemed Liquidation Event is paid (i)
solely in property, rights and/or securities of the acquiring person, firm or
other entity or (ii) in a combination of property, rights and/or securities of
the acquiring person, firm or other entity and cash, such consideration, less
any obligations of the Corporation not specifically assumed in writing by the
potential acquiror under the terms of the contemplated transaction, shall be
distributed among the Corporation's stockholders in the following order and
preference:

                  (A)   First, all cash consideration shall be distributed in
accordance with the procedure set forth in Sections 2(b)(A)-(C) above.

                  (B)   Second, the value of such property, rights and/or
securities shall be determined in good faith by the Board of Directors of the
Corporations and shall be

                                      -7-
<PAGE>

                  distributed pro rata among all holders of the Series B
Preferred Stock, Series A Preferred Stock and Common Stock (treating all holders
of Series B Preferred Stock and Series A Preferred Stock as holders of Common
Stock on as as-converted to New Common Stock basis).

      3.    Voting

            (a)   On any matter presented to the stockholders of the Corporation
for their action or consideration at any meeting of stockholders of the
Corporation (or by written action of stockholders in lieu of meeting), each
holder of outstanding Designated Preferred Stock shall be entitled to the number
of votes equal to the number of whole shares of New Common Stock into which the
Designated Preferred Stock held by such holder is convertible as of the record
date for determining stockholders entitled to vote on such matter. Except as
provided by law or otherwise provided herein, the holders of Designated
Preferred Stock shall vote together with the holders of Common Stock, and with
the holders of any other class or series of capital stock the terms of which so
provide, as a single class.

            (b)   Until the consummation of an Initial Public Offering (as
defined in Section 5), the Corporation shall not, without the affirmative vote
of the holders of at least 60% of the issued and outstanding shares of Series B
Preferred Stock take any action which alters or modifies the rights, preferences
or privileges of the Series B Preferred Stock set forth in Section 2 hereof.

            (c)   Until the consummation of an Initial Public Offering, the
Corporation shall not, without the affirmative vote of the holders of at least
60% of the issued and outstanding shares of capital stock of the Corporation,
voting as a single class on an as-converted to Common Stock basis, effect a
Deemed Liquidation Event.

      4.    Optional Conversion.

The holders of the Designated Preferred Stock shall have conversion rights as
follows (the "Conversion Rights"):

            (a)   Right to Convert. Each share of Series A Preferred Stock and
Series B Preferred Stock shall be convertible, at the option of the holder
thereof, at any time and from time to time, and without the payment of
additional consideration by the holder thereof, into such number of fully paid
and nonassessable shares of New Common Stock as is determined by dividing
$100.00 by the Series A Conversion Price (as defined below) or Series B
Conversion Price (as defined below), as applicable, in effect at the time of
conversion. The "Series A Conversion Price" and "Series B Conversion Price"
shall initially be $10.00 per share. Such initial Series A Conversion Price and
Series B Conversion Price, and the rate at which Series A Preferred Stock and
Series B Preferred Stock may be converted into New Common Stock, shall be
subject to adjustment as provided below.

In the event of a liquidation, dissolution or winding up of the Corporation, the
Conversion Rights shall terminate at the close of business on the last full day
preceding the date fixed for the payment of any such amounts distributable on
such event to the holders of Series A Preferred Stock and Series B Preferred
Stock. In the event of such a liquidation, dissolution or winding up, the
Corporation shall provide to each holder of Series A Preferred Stock and Series
B Preferred

                                      -8-
<PAGE>

Stock notice of such liquidation, dissolution or winding up, which notice shall
(i) be sent at least 15 days prior to the termination of the Conversion Rights
and (ii) state the amount per share of Series A Preferred Stock and Series B
Preferred Stock that will be paid or distributed on such liquidation,
dissolution or winding up, as the case may be.

            (b)   Fractional Shares. No fractional shares of New Common Stock
shall be issued upon conversion of the Series A Preferred Stock or Series B
Preferred Stock. In lieu of any fractional shares to which the holder would
otherwise be entitled, the Corporation shall pay cash equal to such fraction
multiplied by the then fair market of the New Common Stock as determined by the
Board of Directors of the Corporation.

            (c)   Mechanics of Conversion.

                  (i)   In order for a holder of Designated Preferred Stock to
convert such Designated Preferred Stock into New Common Stock, such holder shall
surrender the certificate or certificates for such Designated Preferred Stock,
at the office of the transfer agent for the Designated Preferred Stock (or at
the principal office of the Corporation if the Corporation serves as its own
transfer agent), together with written notice that such holder elects to convert
all or any number of shares of the Designated Preferred Stock represented by
such certificate or certificates. Such notice shall state such holder's name in
which such holder wishes the certificate or certificates for New Common Stock to
be issued. If required by the Corporation, certificates surrendered for
conversion shall be endorsed or accompanied by a written instrument or
instruments of transfer, in form satisfactory to the Corporation, duly executed
by the registered holder or his or its attorney duly authorized in writing. The
date of receipt of such certificates and notice by the transfer agent (or by the
Corporation if the Corporation serves as its own transfer agent) shall be the
conversion date ("Conversion Date"), and the New Common Stock issuable upon
conversion of the shares represented by such certificate shall be deemed to be
outstanding of record as of such date. The Corporation shall, as soon as
practicable after the Conversion Date, issue and deliver at such office to such
holder of Designated Preferred Stock, a certificate or certificates for the
number of shares of New Common Stock to which such holder shall be entitled,
together with cash in lieu of any fraction of a share.

                  (ii)  The Corporation shall at all times when Designated
Preferred Stock shall be outstanding, reserve and keep available out of its
authorized but unissued capital stock, for the purpose of effecting the
conversion of the Designated Preferred Stock, such number of shares of its duly
authorized New Common Stock as shall from time to time be sufficient to effect
the conversion of all outstanding shares of Designated Preferred Stock.

                  (iii) Upon any such conversion, no adjustment to the Series A
Conversion Price or Series B Conversion Price shall be made for any declared but
unpaid dividends on the Designated Preferred Stock surrendered for conversion or
on the New Common Stock delivered upon conversion.

                  (iv)  All Designated Preferred Stock which shall have been
surrendered for conversion as herein provided shall no longer be deemed to be
outstanding and all rights with respect to such shares, including the rights, if
any, to receive notices and to vote, shall immediately cease and terminate on
the Conversion Date, except only the right of the holders

                                      -9-
<PAGE>

                  thereof to receive New Common Stock in exchange therefor and
payment of any dividends declared but unpaid thereon. Any Designated Preferred
Stock so converted shall be retired and cancelled and shall not be reissued.

                  (v)   The Corporation shall pay any and all issue and other
similar taxes that may be payable in respect of any issuance or delivery of New
Common Stock upon conversion of Designated Preferred Stock pursuant to this
Section 4. The Corporation shall not, however, be required to pay any tax which
may be payable in respect of any transfer involved in the issuance and delivery
of New Common Stock in a name other than that in which the Designated Preferred
Stock so converted were registered, and no such issuance or delivery shall be
made unless and until the person or entity requesting such issuance has paid to
the Corporation the amount of any such tax or has established, to the
satisfaction of the Corporation, that such tax bas been paid.

            (d)   Adjustment for Stock Splits and Combinations. If the
Corporation shall at any time or from time to time after the date the
Corporation first issued its Designated Preferred Stock (the "Original Issue
Date") effect a subdivision of the outstanding New Common Stock or combine the
outstanding Designated Preferred Stock, the Series A Conversion Price or Series
B Conversion Price, as applicable, then in effect immediately before that
subdivision or combination shall be proportionately decreased. If the
Corporation shall at any time or from time to time after the Original Issue Date
combine the outstanding New Common Stock or effect a subdivision of the
outstanding Series A Preferred Stock, the Series A Conversion Price or Series B
Conversion Price, as applicable, then in effect immediately before the
combination or subdivision shall be proportionately increased. Any adjustment
under this paragraph shall become effective at the close of business on the date
the subdivision or combination becomes effective.

            (e)   Adjustment for Certain Dividends and Distributions. In the
event the Corporation at any time, or from time to time after the Original Issue
Date shall make or issue, or fix a record date for the determination of holders
of New Common Stock entitled to receive, a dividend or other distribution
payable is additional New Common Stock, then and in each such event the Series A
Conversion Price or Series B Conversion Price, as applicable, then in effect
immediately before such event shall be decreased as of the time of such issuance
or, in the event such a record date shall have been fixed, as of the close of
business on such record date, by multiplying the Series A Conversion Price or
Series B Conversion Price, as applicable, then in effect by a fraction:

                  (i)   the numerator of which shall be the total number of
shares of New Common Stock issued and outstanding immediately prior to the time
of such issuance or the close of business on such record date, and

                  (ii)  the denominator of which shall be the total number of
shares of New Common Stock issued and outstanding immediately prior to the time
of such issuance or the close of business on such record date plus the number of
shares of New Common Stock issuable in payment of such dividend or distribution;

                                      -10-
<PAGE>

provided, however, that if such record date shall have been fixed and such
dividend is not fully paid or if such distribution is not fully made on the date
fixed therefor, the Series A Conversion Price or Series B Conversion Price, as
applicable, shall be recomputed accordingly as of the close of business on such
record date and thereafter the Series A Conversion Price or Series B Conversion
Price, as applicable, shall be adjusted pursuant to this paragraph as of the
time of actual payment of such dividends or distributions; and provided,
further, however, that no such adjustment shall be made if the holders of
Designated Preferred Stock simultaneously receive (i) a dividend or other
distribution of shares of New Common Stock in a number equal to the number of
shares of New Common Stock as they would have received if all outstanding shares
of Designated Preferred Stock had been converted into New Common Stock on the
date of such event or (ii) a dividend or other distribution of Designated
Preferred Stock which is convertible, as of the date of such event, into such
number of shares of New Common Stock as is equal to the number of additional
shares of New Common Stock being issued with respect to each share of New Common
Stock in such dividend or distribution.

            (f)   Adjustments for Other Dividends and Distributions. In the
event the Corporation at any time or from time to time after the Original Issue
Date shall make or issue, or fix a record date for the determination of holders
of New Common Stock entitled to receive, a dividend or other distribution
payable in securities of the Corporation (other than New Common Stock) or in
cash or other property, then and in each such event the holders of Designated
Preferred Stock shall receive, simultaneously with the distribution to the
holders of Common Stock, a dividend or other distribution of such securities,
cash or other property in an amount equal to the amount of such securities, cash
or other property as they would have received if all outstanding shares of
Designated Preferred Stock had been converted into Common Stock on the date of
such event.

            (g)   Adjustment for Merger or Reorganization, etc. Subject to the
provisions of Section 2, if there shall occur any reorganization,
recapitalization, reclassification, consolidation, plan of merger involving the
Corporation in which the New Common Stock (but not the Designated Preferred
Stock) is converted into or exchanged for securities, cash or other property
(other than a transaction covered by paragraphs (d), (e) or (f) of this Section
4), then, following any such reorganization, recapitalization, reclassification,
consolidation or plan of merger, each share of Designated Preferred Stock shall
be convertible into the kind and amount of securities, cash or other property
which a holder of the number of shares of New Common Stock of the Corporation
issuable upon conversion of one share of Designated Preferred Stock immediately
prior to such reorganization, recapitalization, reclassification, consolidation,
plan of merger would have been entitled to receive pursuant to such transaction;
and, in such case, appropriate adjustment (as determined in good faith by the
Board of Directors of the Corporation) shall be made in the application of the
provisions in this Section 4 with respect to the rights and interests thereafter
of the holders of the Designated Preferred Stock, to the end that the provisions
set forth in this Section 4 (including provisions with respect to changes in and
other adjustments of the Series A Conversion Price or Series B Conversion Price
shall thereafter be applicable, as nearly as reasonably may be, in relation to
my securities or other property thereafter deliverable upon the conversion of
the Designated Preferred Stock.

            (h)   No Impairment. The Corporation will not, by amendment of its
Certificate of Incorporation or through any reorganization, transfer of assets,
consolidation,

                                      -11-
<PAGE>

            merger, dissolution, issue or sale of securities or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the terms to be observed or performed hereunder by the Corporation, but will at
all times in good faith assist in the carrying out of all the provisions of this
Section 4 and in the taking of all such action as may be necessary or
appropriate in order to protect the Conversion Rights of the holders of the
Designated Preferred Stock against impairment.

                  (i)   Certificate as to Adjustments. Upon the occurrence of
each adjustment or readjustment of the Series A Conversion Price or Series B
Conversion Price pursuant to this Section 4, the Corporation at its expense
shall, as promptly as reasonably practicable but in any event not later than 15
days thereafter, compute such adjustment or readjustment in accordance with the
terms hereof and furnish to each holder of Designated Preferred Stock a
certificate setting forth such adjustment or readjustment (including the kind
and amount of securities, cash or other property into which the Designated
Preferred Stock is convertible) and showing in detail the facts upon which such
adjustment or readjustment is based. The Corporation shall, as promptly as
reasonably practicable after the written request at any time of any holder of
Designated Preferred Stock (but in any event not later than 15 days thereafter),
furnish or cause to be furnished to such holder a certificate setting forth (i)
the Series A Conversion Price or Series B Conversion Price, as applicable, then
in effect, and (ii) the number of shares of New Common Stock and the amount, if
any, of other securities, cash or property which then would be received upon the
conversion of Designated Preferred Stock.

            (j)   Notice of Record Date. In the event:

                  (i)   the Corporation shall take a record of the holders of
its Common Stock (or other shares or securities at the time issuable upon
conversion of the Designated Preferred Stock) for the purpose of entitling or
enabling them to receive any dividend or other distribution, or to receive any
right to subscribe for or purchase any shares of stock of any class or any other
securities, or to receive any other right; or

                  (ii)  of any capital reorganization of the Corporation, any
reclassification of the Common Stock of the Corporation, any consolidation, plan
of merger of the Corporation with or into another entity (other than a
consolidation, plan of merger in which the Corporation is the surviving entity
and the Common Stock is not converted into or exchanged for any other securities
or property, or any transfer of all or substantially all of the assets of the
Corporation; or

                  (iii) of the voluntary or involuntary dissolution, liquidation
or winding up of the Corporation or other distribution of assets of the
Corporation among its stockholders for the purpose of winding up its affairs,

then, and in each such case, the Corporation will send or cause to be sent to
the holders of the Designated Preferred Stock a notice specifying, as the case
may be, (i) the record date for such dividend, distribution or right, and the
amount and character of such dividend, distribution or right, or (ii) the
effective date on which such reorganization, reclassification, consolidation,
plan of merger, transfer, dissolution, liquidation or winding-up is to take
place, and the time, if any is to be fixed, as of which the holders of record of
Common Stock (or such other stock or securities

                                      -12-
<PAGE>

at the time issuable upon the conversion of the Designated Preferred Stock)
shall be entitled to exchange their Common Stock (or such other shares or
securities) for securities or other property, including cash, deliverable upon
such reorganization, reclassification, consolidation, plan of merger, transfer,
dissolution, liquidation or winding up. Such notice shall be sent at least 10
days prior to the record date or effective date for the event specified in such
notice.

      5.    Mandatory Conversion.

            (a)   Upon the earlier of (A) the closing of the sale of New Common
Stock to the public in a firm commitment underwritten public offering pursuant
to an effective registration statement under the Securities Act of 1933, as
amended, resulting in gross proceeds to the Corporation of at least $25 million
(prior to the deduction of underwriters' commissions, discounts and expenses)
and at a pre-money valuation of the Corporation of no less than $100 million (an
"Initial Public Offering"), or (B) a date agreed to in writing by the holders of
at least sixty percent (60%) of the voting power of the then outstanding
Designated Preferred Stock (each, a "Mandatory Conversion Date"), (i) all
outstanding shares of Designated Preferred Stock shall automatically be
converted into New Common Stock, at the then effective conversion rate and (ii)
such shares may not be reissued by the Corporation as Designated Preferred
Stock.

            (b)   All holders of record of Designated Preferred Stock shall be
given written notice of the Mandatory Conversion Date and the place designated
for mandatory conversion of all such Designated Preferred Stock pursuant to this
Section 5. Such notice need not be given in advance of the occurrence of the
Mandatory Conversion Date. Such notice shall be sent by first class or
registered mail, postage prepaid, or given by electronic communication, in
compliance with the provisions of the Corporation's governing corporate statute,
to each record holder of Designated Preferred Stock. Upon receipt of such
notice, each holder of Designated Preferred Stock shall surrender his, her or
its certificate or certificates for all such shares to the Corporation at the
place designated in such notice, and shall thereafter receive certificates for
the number of shares of New Common Stock to which such holder is entitled
pursuant to this Section 5. On the Mandatory Conversion Date, all outstanding
shares of Designated Preferred Stock shall be deemed to have been converted into
New Common Stock, which shall be deemed to be outstanding of record, and all
rights with respect to the Designated Preferred Stock so converted, including
the rights, if any, to receive notices and vote (other than as a holder of New
Common Stock) will terminate, except only the rights of the holders thereof,
upon surrender of their certificate or certificates therefor, to receive
certificates for the number of shares of New Common Stock into which such shares
of Designated Preferred Stock have been converted, and payment of any declared
but unpaid dividends thereon. If so required by the Corporation, certificates
surrendered for conversion shall be endorsed or accompanied by written
instrument or instruments of transfer, in form satisfactory to the Corporations,
duly executed by the registered holder or by his or its attorney duly authorized
in writing. As soon as practicable after the Mandatory Conversion Date and the
surrender of the certificate or certificates for Designated Preferred Stock, the
Corporation shall cause to be issued and delivered to such holder, or on his or
its written order, a certificate or certificates for the number of full shares
of New Common Stock issuable on such conversion in accordance with the
provisions hereof and cash as provided in Subsection 4(b) in respect of, any
fraction of a share of New Common Stock otherwise issuable upon such conversion.

                                      -13-
<PAGE>

            (c)   All certificates evidencing Designated Preferred Stock which
are required to be surrendered for conversion in accordance with the provisions
hereof shall, from and after the Mandatory Conversion Date, be deemed to have
been retired and cancelled and the Designated Preferred Stock represented
thereby converted into New Common Stock for all purposes, notwithstanding the
failure of the holder or holders thereof to surrender such certificates on or
prior to such date. Such converted Designated Preferred Stock may not be
reissued, and the Corporation may thereafter take such appropriate action
(without the need for stockholder action) as may be necessary to reduce the
authorized number of shares of Designated Preferred Stock accordingly.

      SIXTH. The Directors shall have power to adopt, amend, or repeal the
By-Laws of the Corporation.

      SEVENTH. Election of Directors need not be by written ballot unless the
By-Laws of the Corporation so provide.

      EIGHTH. Except as expressly provided herein, the Corporation shall
indemnify and hold harmless any director or officer of the Corporation or of any
wholly-owned subsidiary from and against any and all expenses and liabilities
that may be imposed upon or incurred in connection with, or as a result of, any
proceeding in which he or she may become involved, as a party or otherwise, by
reason of the fact that he or she is or was such a director or officer, whether
or not he or she continues to be such at the time such expenses and liabilities
shall have been imposed or incurred, to the fullest extent permitted by the DGCL
as it may be amended from time to time.

      The Corporation shall provide indemnification as follows:

      1.    Actions, Suits and Proceedings Other than by or in the Right of the
Corporation. The Corporation shall indemnify each person who was or is a party
or threatened to be made a party to any threatened, pending or completed action,
suit or proceeding, whether civil, criminal, administrative or investigative
(other than an action by or in the right of the Corporation) by reason of the
fact that he or she is or was, or has agreed to become, a director or officer of
the Corporation or of a wholly owned subsidiary thereof, or is or was serving,
or has agreed to serve, at the request of the Corporation, as a director or
officer, partner, employee, agent or trustee of, or in a similar capacity with,
another corporation, partnership, joint venture, trust or other enterprise
(including any employee benefit plan) (all such persons being referred to
hereafter as an "Indemnitee"), or by reason of any action alleged to have been
taken or omitted in such capacity, against all expenses (including, attorneys'
fees), judgments, fines and amounts paid in settlement actually and reasonably
incurred by or on behalf of Indemnitee in connection with such action, suit or
proceeding and any appeal therefrom, if Indemnitee acted in good faith and in a
manner which Indemnitee reasonably believed to be in, or not opposed to, the
best interests of the Corporation, and, with respect to any criminal action or
proceeding, had no reasonable cause to believe his or her conduct was unlawful.
The termination of any action, suit or proceeding by judgment, order,
settlement, conviction or upon a plea of nolo contendere or its equivalent,
shall not, of itself, create a presumption that Indemnitee did not act in good
faith and in a manner which Indemnitee reasonably believed to be in, or not
opposed to, the best interests of the

                                      -14-
<PAGE>

      Corporation, and, with respect to any criminal action or proceeding, had
reasonable cause to believe that his or her conduct was unlawful.

      2.    Actions or Suits by or in the Right of the Corporation. The
Corporation shall indemnify any Indemnitee who was or is a party to or
threatened to be made a party to any threatened, pending or completed action or
suit by or in the right of the Corporation to procure a judgment in its favor by
reason of the fact that Indemnitee is or was, or has agreed to become, a
director or officer of the Corporation, or is or was serving, or has agreed to
serve, at the request of the Corporation, as a director or officer, partner,
employee, agent or trustee of, or in a similar capacity with, another
corporation, partnership, joint venture, trust or other enterprise (including
any employee benefit plan), or by reason of any action alleged to have been
taken or omitted in such capacity, against all expenses (including attorneys'
fees) and, to the extent permitted by law, amounts paid in settlement actually
and reasonably incurred by or on behalf of Indemnitee in connection with such
action, suit or proceeding and any appeal therefrom, if Indemnitee acted in good
faith and in a manner which Indemnitee reasonably believed to be in, or not
opposed to, the best interests of the Corporation, except that no
indemnification shall be made under this Section 2 in respect of any claim,
issue or matter as to which Indemnitee shall have been adjudged to be liable to
the Corporation, unless, and only to the extent, that the Court of Chancery of
Delaware shall determine upon application that, despite the adjudication of such
liability but in view of all the circumstances of the case, Indemnitee is fairly
and reasonably entitled to indemnity for such expenses (including attorneys'
fees) which the Court of Chancery of Delaware shall deem proper.

      3.    Indemnification for Expenses of Successful Party. Notwithstanding
any other provisions of this Article EIGHTH, to the extent that an Indemnitee
has been successful, on the merits or otherwise, in defense of any action, suit
or proceeding referred to in Sections 1 and 2 of this Article EIGHTH, or in
defense of any claim, issue or matter therein, or on appeal from any such
action, suit or proceeding, Indemnitee shall be indemnified against all expenses
(including attorneys' fees) actually and reasonably incurred by or on behalf of
Indemnitee in connection therewith. Without limiting the foregoing, if any
action, suit or proceeding is disposed of, on the merits or otherwise (including
a disposition without prejudice), without (i) the disposition being adverse to
Indemnitee, (ii) an adjudication that Indemnitee was liable to the Corporation,
(iii) a plea of guilty or nolo contendere by Indemnitee, (iv) an adjudication
that Indemnitee did not act in good faith and in a manner he reasonably believed
to be in or not opposed to the best interests of the Corporation, or (v) with
respect to any criminal proceeding, an adjudication that Indemnitee had
reasonable cause to believe his conduct was unlawful, Indemnitee shall be
considered for the purposes hereof to have been wholly successful with respect
thereto.

      4.    Notification and Defense of Claim. As a condition precedent to an
Indemnitee's right to be indemnified, such indemnitee must notify the
Corporation in writing as soon as practicable of any action, suit, proceeding or
investigation involving such Indemnitee for which indemnity will or could be
sought. With respect to any action, suit, proceeding or investigation of which
the Corporation is so notified, the Corporation will be entitled to participate
therein at its own expense and/or to assume the defense thereof at its own
expense, with legal counsel reasonably acceptable to Indemnitee. After notice
from the Corporation to Indemnitee of its election so to assume such defense,
the Corporation shall not be liable to Indemnitee for any legal or other
expenses subsequently incurred by Indemnitee in connection with such action,
suit,

                                      -15-
<PAGE>

      proceeding or investigation, other than as provided below in this Section
4. Indemnitee shall have the right to employ his or her own counsel in
connection with such action, suit, proceeding or investigation, but the fees and
expenses of such counsel incurred after notice from the Corporation of its
assumption of the defense thereof shall be at the expense of Indemnitee unless
(i) the employment of counsel by Indemnitee has been authorized by the
Corporation, (ii) counsel to Indemnitee shall have reasonably concluded that
there may be a conflict of interest or position on any significant issue between
the Corporation and Indemnitee in the conduct of the defense of such action,
suit, proceeding or investigation or (iii) the Corporation shall not in fact
have employed counsel to assume the defense of such action, suit, proceeding or
investigation, in each of which cases the fees and expenses of counsel for
Indemnitee shall be at the expense of the Corporation, except as otherwise
expressly provided by this Article EIGHTH. The Corporation shall not be
entitled, without the consent of Indemnitee, to assume the defense of any claim
brought by or in the right of the Corporation or as to which counsel for
Indemnitee shall have reasonably made the conclusion provided for in clause (ii)
above. The Corporation shall not be required to indemnify Indemnitee under this
Article EIGHTH for any amounts paid in settlement of any action, suit,
proceeding or investigation effected without its written consent. The
Corporation shall not settle any action, suit, proceeding or investigation in
any manner which would impose any penalty or limitation on Indemnitee without
Indemnitee's written consent. Neither the Corporation nor Indemnitee will
unreasonably withhold or delay its Consent to any proposed settlement.

      5.    Advance of Expenses. Subject to the provisions of Section 6 of this
Article EIGHTH, in the event that the Corporation does not assume the defense
pursuant to Section 4 of this Article EIGHTH of any action, suit, proceeding or
investigation of which the Corporation receives notice under this Article, say
reasonable expenses (including attorneys' fees) incurred by or on behalf of an
Indemnitee in defending an action, suit, proceeding or investigation or any
appeal therefrom shall, to the fullest extent permitted by law, be paid by the
Corporation in advance of the final disposition of such matter, and only upon
receipt of and review by the Corporation of written estimates of such expenses;
provided, however, that the payment of such expenses incurred by or on behalf of
Indemnitee in advance of the final disposition of such matter shall be made only
upon receipt of (i) an undertaking by or on behalf of Indemnitee to repay all
amounts so advanced in the event that it shall ultimately be determined that
Indemnitee is not entitled to be indemnified by the Corporation as authorized in
this Article, and (ii) written invoices evidencing such expenses; and provided
further that no such advancement of expenses shall be made under this Article
EIGHTH if it is determined (in the manner described in Section 6) that (i)
Indemnitee did not act in good faith and in a manner he or she reasonably
believed to be in, or not opposed to, the best interests of the Corporation, or
(ii) with respect to any criminal action or proceeding, Indemnitee had
reasonable cause to believe his or her conduct was unlawful. Such undertaking
shall be accepted without reference to the financial ability of Indemnitee to
make such repayment.

      6.    Procedure for Indemnification. In order to obtain indemnification or
advancement of expenses pursuant to Section 1, 2, 3 or 5 of this Article EIGHTH,
an Indemnitee shall submit to the Corporation a written request. Any such
advancement of expenses shall be made promptly, and in any event within 30 days
after receipt by the Corporation of the written request of Indemnitee, unless
the Corporation determines within such 30-day period that Indemnitee did not
meet the applicable standard of conduct set forth, in Section 1, 2 or 5 of this

                                      -16-
<PAGE>

      Article EIGHTH, as the case may be. Any such indemnification, unless
ordered by a court, shall be made with respect to requests under Section 1 or 2
only as authorized in the specific case upon a determination by the Corporation
that the indemnification of Indemnitee is proper because Indemnitee has met the
applicable standard of conduct set forth in Section 1 or 2, as the case may be.
Such determination shall be made in each instance (a) by a majority vote of the
directors of the Corporation consisting of persons who are not at that time
parties to the action, suit or proceeding in question ("disinterested
directors'"), whether or not a quorum, (b) by a committee of disinterested
directors designated by majority vote of disinterested directors, whether or not
a quorum, (c) if there are no disinterested directors, or if the disinterested
directors so direct, by independent legal counsel (who may, to the extent
permitted by law, be regular legal counsel to the Corporation) in a written
opinion, or (d) by the stockholders of the Corporation.

      7.    Remedies. The right to indemnification or advancement of expenses as
granted by this Article EIGHTH shall be enforceable by Indemnitee in any court
of competent jurisdiction. Neither the failure of the Corporation to have made a
determination prior to the commencement of such action that indemnification is
proper in the circumstances because Indemnitee has met the applicable standard
of conduct, nor an actual determination by the Corporation pursuant to Section 6
of this Article EIGHTH that Indemnitee has not met such applicable standard of
conduct, shall be a defense to the action or create a presumption that
Indemnitee has not met the applicable standard of conduct. Indemnitee's expenses
(including attorneys' fees) reasonably incurred in connection with successfully
establishing Indemnitee's right to indemnification, in whole or in part, in any
such proceeding shall also be indemnified by the Corporation.

      8.    Limitations. Notwithstanding anything to the contrary in this
Article EIGHTH, except as set forth in Section 7 of this Article EIGHTH, the
Corporation shall not indemnify an Indemnitee pursuant to this Article EIGHTH in
connection with a proceeding (or part thereof) initiated by such Indemnitee
unless the initiation thereof was approved by the Board of Directors of the
Corporation. Notwithstanding anything to the contrary in this Article EIGHTH,
the Corporation shall not indemnify an Indemnitee to the extent such Indemnitee
is reimbursed from the proceeds of insurance, and in the event the Corporation
makes any indemnification payments to an Indemnitee and such Indemnitee is
subsequently reimbursed from the proceeds of insurance, Indemnitee shall
promptly refund such indemnification payments to the Corporation to the extent
of such insurance reimbursement.

      9.    Subsequent Amendment. To the fullest extent permitted by law, no
amendment, termination or repeal of this Article EIGHTH or of the relevant
provisions of the DGCL or any other applicable laws shall affect or diminish in
any way the rights of any Indemnitee to indemnification under the provisions
hereof with respect to any action, suit, proceeding or investigation arising out
of or relating to any actions, transactions or facts occurring prior to the
final adoption of such amendment, termination or repeal.

      10.   Other Rights. The indemnification and advancement of expenses
provided by this Article EIGHTH shall not be deemed exclusive of any other
rights to which an Indemnitee seeking indemnification or advancement of expenses
may be entitled under any law (common or statutory), agreement or vote of
stockholders or disinterested directors or otherwise, both as to

                                      -17-
<PAGE>

      action in Indemnitee's official capacity and as to action in any other
capacity while holding a directorship or office for the Corporation, and shall
continue as to an Indemnitee who has ceased to be a director or officer, and
shall inure to the benefit of the estate, heirs, executors and administrators of
Indemnitee. Nothing contained in this Article EIGHTH shall be deemed to
prohibit, and the Corporation is specifically authorized to enter into,
agreements with officers and directors providing indemnification rights and
procedures different from those set forth in this Article EIGHTH. In addition,
the Corporation may, to the extent authorized from time to time by its Board of
Directors, grant indemnification rights to other employees or agents of the
Corporation or other persons serving the Corporation and such rights may be
equivalent to, or greater or less than, those set forth in this Article EIGHTH.

      11.   Partial Indemnification. If an Indemnitee is entitled under any
provision of this Article EIGHTH to indemnification by the Corporation for some
or a portion of the expenses (including attorneys' fees), judgments, fines or
accounts paid in settlement actually and reasonably incurred by or on behalf of
Indemnitee in connection with any action, suit, proceeding or investigation and
any appeal therefrom but not, however, for the total amount thereof, the
Corporation shall nevertheless indemnify Indemnitee for the portion of such
expenses (including attorneys' fees), judgments, fines or amounts paid in
settlement to which Indemnitee is entitled.

      12.   Insurance. The Corporation may purchase and maintain insurance, at
its expense, to protect itself and any director or officer of the Corporation or
of a wholly owned subsidiary or another corporation, partnership, joint venture,
trust or other enterprise (including any employee benefit plan) against any
expense, liability or loss incurred by him in any such capacity, or arising out
of his status as such, whether or not the Corporation would have the power to
indemnify such person against such expense, liability or loss under the DGCL.

      13.   Savings Clause. If this Article EIGHTH or any portion hereof shall
be invalidated on any ground by any court of competent jurisdiction, then the
Corporation shall nevertheless indemnify each Indemnitee as to any expenses
(including attorneys' fees), judgments, fines and amounts paid in settlement in
connection with any action, suit, proceeding or investigation, whether civil,
criminal or administrative, including an action by or in the right of the
Corporation, to the fullest extent permitted by any applicable portion of this
Article EIGHTH that shall not have been invalidated and to the fullest extent
permitted by applicable law.

      14.   Definitions. Terms used herein and defined in Section 145(h) and
Section 145(i) of the DGCL shall have the respective meanings assigned to such
terms in such Section 145(h) and Section 145(i).

      NINTH. No director of the Corporation shall be liable to the Corporation
or its stockholders for monetary damages for breach of fiduciary duty as a
director, except for liability (i) for any breach of the director's duty of
loyalty to the Corporation or its stockholders, (ii) for acts or omissions not
in good faith or which involve intentional misconduct or a knowing violation of
law, (iii) under Section 174 of Title 8 of the DGCL or (iv) for any transaction
from which the director derived an improper personal benefit.

                                      -18-
<PAGE>

      TENTH. The Corporation reserves the right to amend, alter, change or
repeal any provision contained in this Certificate of Incorporation, in the
manner now or hereafter prescribed by statute, and all rights conferred upon
stockholders herein are granted subject to this reservation.

      ELEVENTH Except as provided in the provisions establishing a class of
stock, the number of authorized shares of any class or series of stock may be
increased or decreased (but not below the number of shares thereof then
outstanding) by the affirmative vote of the holders of a majority of the capital
stock of the Corporation entitled to vote irrespective of the provisions of
Section 242(b)(2) of the DGCL.

                                      ****

                                      -19-
<PAGE>

IN WITNESS WHEREOF, the undersigned has signed this Amended and Restated
Certificate of Incorporation on behalf of the Corporation this "____ day of
________, 2003."

                                 By:
                                      ---------------------
                                      Name:  Nick Hayes
                                      Title: Chief Operating Officer and Chief
                                              Financial Officer

                                      -20-
<PAGE>

                                  EXHIBIT 2(d)

                               PREDIX DELIVERABLES

2(d)(1) Predix Resolutions

2(d)(2) Predix Notice

2(d)(3) Predix Amended Articles of Association

<PAGE>

                           PREDIX PHARMACEUTICALS LTD.

                            UNAMIMOUS WRITTEN CONSENT
                               OF THE SHAREHOLDERS

The undersigned, comprising all of the shareholders of Predix Pharmaceuticals
Ltd. (the "Company"), an Israeli company, acting in lieu of meeting pursuant to
the Articles of Association of the Company, do hereby consent in writing without
meeting as follows:

IT IS HEREBY RESOLVED to approve the Amended and Restated Articles of
Association of the Company, substantially in the form attached hereto as EXHIBIT
A subject to the consummation of the merger transaction contemplated between the
Company and Physiome Sciences, Inc., prior to August 1, 2003, and effective as
of the closing thereof.

IT IS HEREBY RESOLVED to authorize any director of the Company to sign the
Notice provided to the Registrar of Companies, implementing this resolution.

IN WITNESS WHEREOF, we the undersigned, have executed this consent this 1st day
of July, 2003.

__________________________________     _______________________________________
Yozma II (Israel) L.P.                 YVC - Yozma Management & Investments
                                       Ltd., acting as a trustee for and on
                                       behalf of Yozma II (B.V.I.) L.P.

__________________________________     _______________________________________
PCM Venture Capital L.P.               OrbiMed Associates, LLC

__________________________________     _______________________________________
PW Juniper Crossover Fund, L.L.C.      Caduceus Private Investments, L.P.

__________________________________
Frederick Frank
<PAGE>

                            THE COMPANIES LAW - 1999

                              NOTICE OF RESOLUTION

COMPANY'S NAME: PREDIX PHARMACEUTICALS LTD.

PRIVATE COMPANY NO.: 51-286430-7

The above-mentioned Company hereby gives Notice, under Section 140 of the
Companies Law - 1999, according to which the Company's special general meeting
has adjourned on the 1st day of July, 2003, and has resolved the following
resolutions:

To replace the Company's Articles of Association by the Amended and Restated
Articles of Association, attached to this Notice as APPENDIX A hereto,
constituting an integral part thereof, subject to the consummation of the merger
transactions contemplated between the Company and Physiome Sciences, Inc., prior
to August 1, 2003,and effective as of the closing thereof.

_____________________________
[        ], Director

<PAGE>

                           ARTICLES OF ASSOCIATION OF
                           PREDIX PHARMACEUTICALS LTD.

PRELIMINARY

1.    Interpretation

In these Articles, unless the context otherwise requires:

These ARTICLES - shall mean the Articles of Association of the Company as shall
be in force from time to time.

The BOARD OF DIRECTORS - shall mean the Board of Directors of the Company as
same shall be from time to time.

The COMPANY - shall mean Predix Pharmaceuticals Ltd.

The LAW - shall mean the Companies Law 5759-1999 as shall be in effect from time
to time and any other law that shall be in effect from time to time with respect
to companies and that shall apply to the company.

The OFFICE - shall mean the registered office of the Company as it shall be from
time to time.

An ORDINARY RESOLUTION - shall mean a resolution that requires a majority of the
votes of the issued and outstanding share capital present or otherwise
represented at a meeting, entitled to vote thereat and voting thereon.

An ORDINARY SHARE - shall mean an Ordinary Share of the Company with nominal
value NIS 0.10, or any other nominal value as may be set from time to time in
Article 9 of these Articles.

A SPECIAL RESOLUTION - shall mean a resolution that requires a majority of 75%
(seventy five percent) of the votes of the issued and outstanding share capital
present or otherwise represented at a meeting, entitled to vote thereat and
voting thereon.

2.    In these Articles, subject to this article and unless the context
otherwise requires, words and expressions defined in the Law or any modification
thereof in force on the date at which these Articles or any amendment hereto
become binding on the Company shall have the meanings so defined, and words and
expressions importing the singular shall include the plural and vice versa and
words and expressions importing the masculine gender shall include the feminine
gender; and words and expressions importing persons shall include bodies
corporate.

3.    The captions and titles of the Articles are for convenience only and shall
not be deemed a part hereof or affect the construction of any provision hereof.

4.    If an Article has been added to these Articles which contradicts an
original Article found in these Articles, the Article added shall take
precedence, provided that it has been adopted in compliance with the provisions
of these Articles.

<PAGE>

PRIVATE COMPANY

5.    The Company is a private company, and

      (a)   the right to transfer the shares of the Company shall not be
restricted.

      (b)   the number of shareholders of the Company (excluding persons who are
in the employment of the Company, and persons who, having been formerly in the
employment of the Company were while in that employment and have continued after
the termination of that employment to be shareholders in the Company) shall be
limited to fifty (50), provided that, for the purposes of this provision, where
two or more persons jointly hold one or more shares in the Company, they shall
be treated as a single shareholder.

      (c)   no invitation shall be issued to the public to subscribe for any
shares or debentures or debenture stocks of the Company.

Any reference herein in an offering to the public of the Company's securities
shall not derogate from the provisions of this Article 5, and no such offering
shall be effected prior to adopting such amendments to these Articles as are
legally required therefor.

LIMITED LIABILITY

6.    The shareholders' liability for the Company's obligations is limited to
the payment of the nominal value of the Company's shares, all subject to Section
304 of the Law.

PURPOSE OF THE COMPANY

7.    Subject to any limitations contained herein, the Company shall engage in
any legal occupation and/or business.

OFFICE

8.    The registered office of the Company shall be at such place as the
directors shall from time to time appoint.

THE CAPITAL

9.    The capital of the Company is NIS 3,371,912 divided into 33,719,120
Ordinary Shares of nominal value NIS 0.10 each

10.   RESERVED.

11.   Each Ordinary Share shall be entitled to all rights in the Company.

12.   RESERVED.

13.   RESERVED.

                                       2
<PAGE>

14.   RESERVED.

15.   RESERVED.

16.   RESERVED.

17.   RESERVED.

18.   RESERVED.

19.   RESERVED.

INCREASE OF SHARE CAPITAL

20.   The Company may, from time to time, by Special Resolution, increase its
registered share capital - whether or not all of its shares have been issued, or
whether the shares issued have been paid in full, by the creation of new shares.
This new share capital shall be in such amount, divided into shares of such
nominal amounts, and have such preferable or deferred or other special rights
(subject always to the special rights conferred upon an existing class of
shares), subject to any conditions and restrictions with respect to dividends,
return of capital, voting or otherwise, all as shall be directed by the General
Meeting in its resolution sanctioning the increase of share capital.

21.   Except to the extent otherwise provided in such resolution, the new share
capital shall be deemed to be part of the original share capital of the Company
and shall be subject to all the provisions applicable to the original share
capital.

SPECIAL RIGHTS; MODIFICATION OF CAPITAL AND RIGHTS

22.   Subject to the provisions of the Law:

      (a)   the Company may, from time to time, by Special Resolution, change,
convert, broaden, add or vary in any other manner, the rights, advantages,
restrictions and provisions attached at that time to one or more of the classes
of shares, after passing a Special Resolution at a meeting of the class so
affected, or receipt of the consent in writing of the holders of seventy five
percent (75%) of the issued shares of the class so affected. The provisions of
these Articles relating to General Meeting shall, mutatis mutandis, apply to any
separate General Meeting of the holders of the shares of a particular class;
provided, however, that the requisite quorum at any such separate General
Meeting shall be one or more shareholders present in person or proxy and holding
not less than fifty one percent (51%) of the issued shares of such class.

      (b)   the Company may, from time to time, do the following:

      (i)   consolidate and divide all or any of its issued or unissued share
capital into shares of larger nominal value than its existing shares;

      (ii)  subdivide its shares (issued or unissued) or any of them, into
shares of smaller nominal value than is fixed in Article 9 above and grant to
one or more shares, in the resolution concerning

                                       3
<PAGE>

such subdivision, a preferable right or advantage with respect to dividend,
capital, voting or otherwise over the remaining share or other similar shares;

      (iii) cancel any shares which, at the date of the adoption of such
resolution, have not been taken or agreed to be taken by any person, and reduce
the amount of its share capital by the amount of the shares so canceled, or

      (iv)  reduce its share capital and any fund reserved for capital
redemption in any manner it shall deem correct, all in accordance with the
provisions of the Law.

      (v)   issue redeemable shares and redeem the same, subject to the Law and
any other applicable law.

      (c)   With respect to any consolidation of issued shares into shares of
larger nominal value, and with reject to any other action which may result in
fractional shares, the Board of Directors may, as it deems fit, settle any
difficulty which may arise with regard thereto, and in doing so may take one or
more of the following actions:

      (i)   determine, as to the holder of shares so consolidated, which issued
shares shall be consolidated into each share of larger nominal value;

      (ii)  issue, in contemplation of or subsequent to such consolidation or
other action, a sufficient number of shares to preclude or remove holdings of
fractional shares;

      (iii) redeem, in the case of redeemable preference shares, and subject to
the Law, a sufficient number of shares to preclude or remove holdings of
fractional shares;

      (iv)  cause the transfer of deemed fractional shares by certain
shareholders of the Company to other shareholders as to most expediently
preclude or remove any deemed holdings of fractional shares, and cause the
transferees to pay the transferors the fair value of deemed fractional shares so
transferred, and the Board of Directors is hereby authorized to act as agent for
the transferors and transferees with power of substitution for purposes of
implementing the provisions of this sub-article 22(c)(iv).

SHARE CERTIFICATES AND REGISTERED HOLDER

23.   Share certificates shall be issued bearing the rubber stamp or printed
name of the Company and the signature of one or more Directors or of any other
person or persons so appointed by the Board of Directors.

24.   Each shareholder shall be entitled to receive from the Company without
payment one numbered certificate for all the shares of any class registered in
his name, and if the Board of Directors so approves, to several certificates,
each for one or more of such shares. Each certificate shall specify the serial
numbers and class of the shares represented thereby and may also specify the
amount paid up thereon. However, if the share(s) are held by joint holders, the
Company shall not be obligated to issue more than one certificate to all the
joint holders, and the delivery of such certificate to one of the joint holders
shall be deemed to be a delivery to all of the joint holders.

                                       4
<PAGE>

25.   A share certificate registered in the names of joint holders shall be
delivered to the person first named in the shareholders register.

26.   If a share certificate is defaced, lost or destroyed, it may be replaced,
upon payment of such fee, if any, and upon the, furnishing of such evidence of
ownership and indemnity, as the Board of Directors may determine.

27.   The Company shall be entitled to treat the registered holder of any share
as the absolute owner thereof, and, accordingly, shall not, except by order of a
court of competent jurisdiction, or as required by statute be bound to recognize
any equitable or other claim to, or interest in such share on the part of any
other person. If two or more persons are registered as joint holders of any
share(s), they shall be jointly and severally liable for any calls or any other
liability with respect to such share(s). However, with respect to voting, power
of attorney and furnishing notices, the Company may treat the holder first
appearing in the shareholder register as the sole owner of such share(s) unless
all other registered joint holders notify the Company in writing as to which of
them is to be treated as sole owner.

28.   In the case that two or more persons are registered together as holders of
a share, each one of them shall be permitted to give receipts binding all joint
holders for dividends or other monies in connection with a share and the Company
shall be permitted to pay all dividends or other moneys due with respect to such
share to one or more of the joint holders, as it shall choose.

PAYMENT IN INSTALLMENTS AND CALLS ON SHARES

29.   If by the terms of issuance of any share, the price or any part thereof
shall be payable in installments, every such installment shall, when due, be
paid to the Company by the then registered holder(s) of the share or the
person(s) entitled thereto.

30.   (a) The Board of Directors may, from time to time, make such calls as it
may deem fit upon shareholders in respect of any sum unpaid on shares held by
such shareholders which is not, by the terms of issuance thereof or otherwise,
payable at a fixed time, and each shareholder shall pay the amount of every call
so made upon him (and of each installment thereof if the same is payable in
installments), to the person(s) and at the time(s) and place(s) designated by
the Board of Directors, and any such time(s) may be thereafter extended and/or
such person(s) or place(s) changed. Unless otherwise stipulated in the
resolution of the Board of Directors (and in the notice hereafter referred to),
each payment in response to a call shall be deemed to constitute a pro rata
payment on account of all shares in respect of which such call was made.

      (b)   Notice of any call shall be given in writing to the shareholder(s)
in question not less than fourteen (14) days prior to the time of payment,
specifying the time and place of payment, and designating the person to whom
such payment shall be made, provided, however, that before the time for any such
payment, the Board of Directors may, by notice in writing to such
shareholder(s), revoke such call in whole or in part, extend the time for
payment, or change the designated person or place. Only one notice calling for
payment need be given in connection with a call payable in installments.

      (c)   If, by the terms of issuance of any share or otherwise, any amount
is made payable at any fixed time, every such amount shall be payable at such
time as if it were a call duly made by the

                                       5
<PAGE>

Board of Directors and of which due notice had been given, and all the
provisions herein contained with respect to calls shall apply to each such
amount.

      (d)   The joint holders of a share shall be jointly and severally liable
to pay all calls in respect thereof and all interest payable thereon.

      (e)   Any amount unpaid in respect of a call shall bear interest from the
date on which it is payable until actual payment thereof, at such rate (not
exceeding the then prevailing debitory rate charged by leading commercial banks
in Israel), and at such time(s) as the Board of Directors may prescribe.

      (f)   Upon the issuance of shares, the Board of Directors may provide for
differences among the holders of such shares as to the amount of calls and/or
the times of payment thereof.

      (g)   With the approval of the Board of Directors, any shareholder may pay
the Company any amount not yet payable in respect of his shares, and the Board
of Directors may approve the payment of interest on any such amount until the
same would be payable if it had not been paid in advance, at such rate and
time(s) as may be approved by the Board of Directors. The Board of Directors may
at any time cause the Company to repay all or any part of the money so advanced,
without premium or penalty. Nothing in this Article 30 shall derogate from the
right of the Board of Directors to make any call before or after receipt by the
Company of any such advance.

      (h)   A shareholder shall not be entitled to receive dividends nor to use
any right they have unless he has paid all the calls that may be made from time
to time, with respect to amounts outstanding on his shares whether he is the
sole holder or holds such shares jointly with others.

FORFEITURE AND SURRENDER

31.   (a) If a shareholder fails to pay any amount payable in respect of a call,
or interest thereon as provided for in these Articles, on or before the day
fixed for payment of same, the Company, by resolution of the Board of Directors,
may at any time thereafter, so long as said amount or interest remains unpaid,
forfeit all or any of the shares in respect of which such call had been made.
Any expense incurred by the Company in attempting to collect any such amount or
interest, including, inter alia, attorneys' fees and costs of suit, shall be
added to, and shall, for all purposes (including the accrual of interest
thereon), constitute a part of the amount payable to the Company in respect of
such call.

      (b)   Upon the adoption of a resolution of forfeiture, the Board of
Directors shall cause notice thereof to be given to such shareholder, which
notice shall state that, in the event of the failure to pay the entire amount so
payable within a period stipulated in the notice (which period shall not be less
than fourteen (14) days and which may be extended by the Board of Directors),
such shares shall be ipso facto forfeited, provided, however, that, prior to the
expiration of such period, the Board of Directors may nullify such resolution of
forfeiture, but no such nullification shall estop the Board of Directors from
adopting a further resolution of forfeiture in respect of the non-payment of
amount due on such share(s).

      (c)   Whenever shares are forfeited as herein provided, all declared but
unpaid dividends in respect thereof shall be deemed to have been forfeited at
the same time.

                                       6
<PAGE>

      (d)   The Company, by resolution of the Board of Directors, may accept the
voluntary surrender of any share.

      (e)   Any share forfeited or surrendered as provided herein shall become
the property of the Company, and shall be dormant and without any rights
attached to such share(s) until such time and subject to the provisions of these
Articles, as these shares are sold, re-issued or otherwise disposed of as by the
Board of Directors, in its sole discretion.

      (f)   Any shareholder whose shares have been forfeited or surrendered
shall cease to be a shareholder in respect of the forfeited or surrendered
shares, but shall, notwithstanding, be liable to pay, and shall forthwith pay,
to the Company, all calls, interest and expenses owing upon or in respect of
such shares at the time of forfeiture or surrender, together with interest
thereon from the time of forfeiture or surrender until actual payment at the
rate prescribed it Article 30(e) above, and the Board of Directors, in its
discretion, may enforce the payment of such moneys, or any part thereof, but
shall not be under any obligation to do so in the event of such forfeiture or
surrender, the Company, by resolution of the Board of Directors, may accelerate
the date(s) of payment of any or all amounts then owed by the shareholder in
question (but not yet due) in respect of all shares owned by such shareholder,
solely or jointly with another, and in respect of any other matter or
transaction whatsoever.

      (g)   The Board of Directors may at any time, before any share so
forfeited or surrendered shall have been sold, re-issued or otherwise disposed
of, nullify the forfeiture or surrender on such conditions as it deems fit, but
no such nullification shall estop the Board of Directors from re-exercising its
powers of forfeiture pursuant to this Article 31.

LIEN

32.   (a) Except to the extent the same may be waived or subordinated in
writing, the Company shall have a first and paramount lien upon all the shares,
not fully paid, registered in the name of each shareholder (without regard to
any equitable or other claim or interest in such shares on the part of any other
person), and upon the proceeds of the sale thereof, for any portion of the
consideration for those shares held by such shareholder, whether or not the date
of payment of such portion of the consideration shall have actually arrived.
Such lien shall extend to all dividends from time to time declared in respect of
such share(s). Unless otherwise provided, the registration by the Company of a
transfer of shares shall be deemed to be a waiver on the part of the Company of
the lien (if any) existing on such shares immediately prior to such transfer.

      (b)   The Board of Directors may cause the Company to sell any share
subject to such lien when any such consideration payment has become due, in such
manner as the Board of Directors may think fit, but no such sale shall be made
unless such debt, liability or engagement has not been satisfied within fourteen
(14) days after written notice of the intention to sell shall have been served
on such shareholder, his executors or administrators.

      (c)   The net proceeds of any such sale, after payment of the costs
thereof, shall be applied towards satisfaction of the payment due from such
shareholder an account of the unpaid portion of the consideration due on his
shares (whether or not such portion of the consideration has become due), or

                                       7
<PAGE>

any specific part of same (as the Company may determine), and the residue (if
any) shall be paid to the shareholder, his executors, administrators or assigns.

      (d)   Upon any sale of shares after forfeiture, surrender or for enforcing
a lien, the Board of Directors may appoint a person to execute an instrument of
transfer of the shares so sold and cause the purchaser's name to be entered in
the shareholder's register in respect of such shares, and the purchaser shall
not be required to inquire upon the adequacy of the proceedings, or to the
application of the purchase money, and after his name has been entered in the
shareholder's register in respect of any such shares, the validity of the sale
shall not be impeached by any person, and the remedy of any person aggrieved by
the sale shall be in damages only and against the Company exclusively.

TRANSFER OF SHARES AND THE MANAGEMENT THEREOF

33.   No transfer of shares shall be registered unless a proper instrument of
transfer, in writing, (in form and substance satisfactory to the Board of
Directors) has been submitted to the Company, together with the share
certificate(s) and such other evidence of title as the Board of Directors may
reasonably require. Until the transferee has been registered in the
shareholder's register in respect of the shares so transferred, the Company may
continue to regard the transferor as the owner thereof. The Board of Directors
may not prescribe a reasonable fee for the registration of a transfer.

34.   (a) The Board of Directors any suspend the registration of transfers
during the fourteen (14) days immediately prior to the Annual or Extraordinary
General Meeting.

      (b)   To avoid any doubts, neither the suspension of registration of
transfers pursuant to Article 34(a) above nor the determination of a record date
pursuant to Article 39(c) below shall constitute nor be deemed as closing of any
of the above records of registers.

35.   (a) In case of a share registered in the names of two or more holders, the
Company may recognize the survivor(s) as the sole owner(s) thereof unless and
until the provisions of Article 35(b) have been effectively invoked.

      (b)   Any person becoming entitled to a share in consequence of the death
of any person, upon producing evidence of the grant of probate or letters of
administration or declaration of succession (or such other evidence as the Board
of Directors may reasonably deem sufficient that he sustains the character in
respect of which he proposes to act under this Article or of his title), shall
be registered as a shareholder in respect of such share, or may, subject to the
regulations as to transfer herein contained, transfer such share.

36.   (a) The Company may recognize the receiver or liquidator of any corporate
shareholder in winding-up or dissolution, or the receiver or trustee in
bankruptcy of any shareholder, as being entitled to the shares registered in the
name of such shareholder.

      (b)   The receiver or liquidator of a corporate shareholder in winding-up
or dissolution, or the receiver or trustee in bankruptcy of any shareholder,
upon producing such evidence as the Board of Directors may deem sufficient that
he sustains the character in respect of which he proposes to act under this
Article or of his title, shall with the consent of the Board of Directors (which
the Board of Directors may grant or refuse in its absolute discretion), be
registered as a shareholder in respect of such shares, or may, subject to the
regulations as to transfer herein contained, transfer such shares.

                                       8
<PAGE>

GENERAL MEETINGS

37.   An Annual General Meeting shall be held once in every calendar year and
not later then fifteen (15) months after the holding of the last general
meeting, at such time and at such place either within or without the State of
Israel as may be determined by the Board of Directors. All other shareholders
meetings shall be called `EXTRAORDINARY MEETINGS'. An Annual General Meeting or
an Extraordinary Meeting of the shareholders shall be referred to as a `GENERAL
MEETING'. A meeting of holders of a class of shares shall be referred to as a
`CLASS' or `CATEGORY' Meeting.

38.   Whenever it deems fit, the Board of Directors may convene a General
Meeting other than the Annual General Meeting, to be held at such time and
place, within or outside the State of Israel, as may be determined by the Board
of Directors, and shall be obliged to do so upon a requisition(s) in writing
submitted in accordance with the provisions of the Law regarding such meetings.

NOTICE OF GENERAL MEETINGS

39.   (a) Not less than seven (7) days' prior notice shall be given of every
General Meeting. Each such notice shall specify the place and the day and hour
of the meeting and the general nature of each item to be acted upon thereat.
Notice shall be given to all shareholders who would be entitled to attend and
vote at such meeting, on the record date (as determined pursuant to Article
39(c) below). Notwithstanding anything herein to the contrary, with the consent
of all shareholders entitled to vote thereon, a resolution may be proposed and
passed at such meeting although a lesser notice than prescribed above has been
given.

      (b)   The accidental omission to give notice of a meeting to any
shareholder, or the non-receipt of notice sent to such shareholder, shall not
invalidate the proceedings at such meeting.

      (c)   The Board of Directors may fix a record date to determine the
shareholders entitled to notice of and to vote at any meeting of shareholders or
any adjournment thereof, which record date shall not precede the date upon which
the resolution fixing the record date is adopted by the Board of Directors, and
which record date shall not be more than sixty (60) nor less than ten (10) days
before the date of such meeting. If no record date is fixed by the Board of
Directors, the record date for determining shareholders entitled to notice of or
to vote at the Meeting shall be at the close of business on the day preceding
the day on which such Board meeting is held. A determination of shareholders of
record entitled to notice of or to vote at a meeting of shareholders shall apply
to any adjournment of the meeting; provided, however, that the Board of
Directors may fix a new record date for the adjourned meeting.

QUORUM AND PROCEEDINGS AT GENERAL MEETINGS

40.   (a) One or more shareholders (not in default in payment of any sum
referred to in Article 31 above) holding in the aggregate at least 51% of the
Company's issued and outstanding share capital present in person or by proxy and
holding shares conferring in the aggregate a simple majority of the voting power
of the Company, shall constitute a quorum at General Meetings. No

                                       9
<PAGE>

business shall be transacted at a General Meeting, or at any adjournment
thereof, unless the requisite quorum is present when the meeting proceeds to
conduct its business.

      (b)   If within an hour from the time appointed for the meeting a quorum
is not present, the meeting, if convened upon requisition pursuant to Sections
63 or 64 of the Law, shall be dissolved, but in any other case it shall stand
adjourned to the 5th (fifth) business day thereafter, at the same time and
place. No business shall be transacted at any adjourned meeting except business
which might lawfully have been transacted at the meeting as originally called.
At such adjourned meeting, any one (1) shareholder (not in default as aforesaid)
present in person or by proxy, shall constitute a quorum; provided that if the
original meeting was convened upon a requisition of the shareholders under
Sections 63 or 64 of the Law, then the adjourned meeting shall only be held if
the number of shareholders participating in such a meeting constitute the
minimum number of shareholders as are required in accordance with these Sections
63 or 64 of the Law.

      (c)   Participation by Conference Calls.
Shareholders may participate by means of telephone conference call or other
similar communications equipment by means of which all persons participating in
the meeting can hear one another and subject to a confirmation of attendance to
the Chairman of the meetings made by the Company's secretary or any other
officer or director so designated for such purpose. Such participation shall
constitute attendance in person in any such meeting.

Under the Law or under any other applicable law and subject to the provisions of
these Articles, the following matters shall, if and when applicable, be resolved
upon by the General Meeting:

      (1)   changes in the Articles, as specified in Section 20 of the Law;

      (2)   exercise of the powers of the Board of Directors in accordance with
      the provisions of Section 52(a) of the Law;

      (3)   appointment of the Company's Auditor, the terms of its engagement
      and termination of engagement in accordance with the provisions of
      Sections 154 through 167 of the Law;

      (4)   approval of actions and transactions that require approval by the
      General Meeting under the provisions of Sections 255 and 268 through 275
      of the Law;

      (5)   the increase and reduction of the registered share capital, in
      accordance with the provisions of Sections 286 and 287 the Law; and

      (6)   a merger, as described in Section 320(a) of the Law.

Subject to the provisions of these Articles and the Law, the function of the
General Meeting shall be to receive and to deliberate with respect to the profit
and loss statements, the balance sheets, the ordinary reports and accounts of
the directors and auditors and to fix their salaries and to address any other
matter than can lawfully be addressed by a General Meeting pursuant to the Law.

CHAIRMAN

                                       10
<PAGE>

40.   The Chairman, if any, of the Board of Directors shall preside as Chairman
at every General Meeting of the Company. If there is no Chairman, or the
Chairman is not present within fifteen (15) minutes from the time fixed for the
meeting or is otherwise unwilling to preside as Chairman, the shareholders
present shall elect one of the directors to preside as Chairman. If no directors
are present, or if they all refuse to preside at the meeting, the shareholders
present shall elect one of their own to preside over the meeting. The office of
Chairman shall not, by itself, entitle its holder to vote at any General Meeting
nor shall it entitle such holder to a second or casting vote (without
derogating, however, from the rights of such Chairman to vote as a shareholder
or proxy of a shareholder if, in fact, he is also a shareholder or such proxy).

ADOPTION OF RESOLUTIONS AT GENERAL MEETINGS

41A.  (a) Every matter submitted to a General Meeting shall be decided by a show
of hands, but if a written ballot is demanded by any shareholder present in
person or by proxy and entitled to vote at the meeting, the same shall be
decided by such ballot. A written ballot may be demanded before the proposed
resolution is voted upon or immediately after the declaration by the Chairman of
the results of the vote by a show of hands. If a vote by written ballot is taken
after such declaration, the results of the vote by a show of hands shall be of
no effect, and the proposed resolution shall be decided by such written ballot.

      (b)   The demand for a written ballot may be withdrawn at any time before
the ballot is conducted. Such a withdrawal by one shareholder shall not preclude
any other shareholder from demanding that a written ballot be taken.

      (c)   The demand for a written ballot shall not prevent the continuance of
the meeting for the transaction of business other than the question on which the
written ballot has been demanded.

      (d)   A declaration by the Chairman of the meeting that a resolution has
been carried unanimously, or carried by a particular majority, or lost, and an
entry to that effect in the minute book of the Company, shall be conclusive
evidence of the fact without need for proof of the number or proportion of the
votes recorded in favor of or against such resolution.

      (e)   Except as otherwise required in these Articles, an Ordinary
Resolution shall be deemed to have been passed at a General Meeting if it
received the majority required to pass an Ordinary Resolution and a Special
Resolution shall be deemed to have been passed at a General Meeting if it
received the majority required to pass a Special Resolution.

Resolution in Writing. A resolution in writing signed by all the shareholders of
the Company or to which all such shareholders have given their written consent
(by letter, facsimile, e-mail followed by an executed written instrument of
confirmation or otherwise) shall be deemed to have been unanimously adopted by a
General Meeting duly convened and held.

POWER TO ADJOURN

42.   (a) The Chairman of a General Meeting at which a quorum is present may,
with the consent of the holders of a majority of the voting power represented in
person or by proxy and voting on the question of adjournment (and shall if so
directed by the meeting), adjourn the meeting from

                                       11
<PAGE>

time to time and from place to place, but no business shall be transacted at any
adjourned meeting except business which might lawfully have been transacted at
the meeting, as originally called.

      (b)   other than with respect to adjournment pursuant to Article 40(b) all
shareholders entitled to notice of a General Meeting shall be entitled to notice
of its adjournment, which notice shall be given in the manner required for the
meeting as originally called.

VOTING POWERS AND RIGHTS OF SHAREHOLDERS

43.   Subject to the provisions of Articles 10, 11 and 44(a) and subject to any
Articles herein conferring special rights as to voting, or restricting the right
to vote, every shareholder, present at a meeting, personally or by proxy, shall
have one vote for each share held by him of record, on every resolution, without
regard to whether the vote hereon is conducted by a show of hands, by written
ballot or by any other means.

44.   (a) No shareholder shall be entitled to vote at any General Meeting (or be
counted as a part of the quorum thereat), unless all calls and other sums then
payable by him in respect of his shares in the Company have been paid.

      (b)   A company or other corporate body being a shareholder of the Company
may duly authorize any person to be its representative at any meeting of the
Company. Any person so authorized shall be entitled to exercise on behalf of
such shareholder all the power which the latter could have exercised if it were
an individual shareholder. Upon the request of the Chairman of the meeting,
written evidence of such authorization (in form acceptable to the Chairman)
shall be delivered to him.

      (c)   Any shareholder entitled to vote may vote either personally or by
proxy (who need not be a shareholder of the Company), or, if the shareholder is
a company or other corporate body, by a representative authorized pursuant to
Article 44(b).

      (d)   If two or more persons are registered as joint holders of any share,
the vote of the senior(as defined in Article 27 above) who tenders a vote, in
person or by proxy, shall be accepted to the exclusion of the vote(s) of the
other joint holder(s).

PROXIES

45.   (a) The instrument appointing a proxy shall be in writing and shall be
substantially in the following form, or in any usual or common form or in such
other form as may be approved by the Board of Directors. It shall be duly
executed by the shareholder appointing the proxy or his duly authorized attorney
or, if such shareholder is a company or other corporate entity, under its stamp
or the hand of its duly authorized agent(s) or attorney(s):

Form of Proxy
"I, ___________, of _____________, a shareholder holding shares in Predix
Pharmaceuticals Ltd. and entitled to _____ votes hereby appoint _____________,
of _________, or in his place _____________, of ___________________, to vote in
my name and in my place at the General

                                       12
<PAGE>

Meeting (regular, extraordinary, adjourned - as the case may be) of the Company
to be held on the ____ day ________ 20__, and at any adjournment thereof.

In witness whereof, I have hereby affixed my signature the _____ day of________
20__.

______________________________
Appointer's Signature

I hereby confirm that the foregoing
instrument was signed by the appointer.

_____________________________
(name, profession and address)

      (b)   The instrument appointing a proxy (and the power of attorney or
other authority, if any, under which such instrument has been signed) shall
either be delivered to the Company (at its registered office, or at its
principal place of business or at the offices of its transfer agent or at such
place as the Board of Directors may specify) not less than forty-eight (48)
hours before the time fixed for the meeting at which the person named in the
instrument proposes to vote, or presented to the Chairman at such meeting.

      (c)   A vote cast pursuant to an instrument appointing a proxy shall be
valid notwithstanding the previous death of the appointing shareholder (or of
his attorney-in-fact, if any, who signed such instrument), such shareholders'
later incapacity, or the revocation of the appointment or the transfer of the
share in respect of which the vote is cast, provided no notice of such death,
incapacity, revocation or transfer shall have been received by the Company or by
the Chairman of the meeting before such vote is cast and provided, further, that
the appointing shareholder, if present in person at said meeting, may revoke the
appointment by means of a writing, oral notification to the Chairman, or
otherwise.

      (d)   A shareholder is entitled to vote by a separate proxy with respect
to each share held by him, provided that each proxy as aforesaid shall have a
separate letter of appointment containing the serial number of the share(s) with
respect to which the proxy is entitled to vote. If a specific share is included
by the holder in more than one letter of appointment, that share shall not
entitle any of the holders of such instrument to a vote.

      (e)   An instrument appointing a proxy and which is not limited in time
shall be valid for twelve (12) months after the date of its execution.
Thereafter, if necessary, a new instrument of appointment needs to be executed.
If the appointment is for a limited period, the instrument shall be valid for
the period stated therein.

BOARD OF DIRECTORS

46.   (a) Powers and Duties of Directors. Subject to the provisions of these
Articles, the Board of Directors shall set the Company's policy(ies) and shall
supervise the actions of the General Manager and his office, as part of its
duties the Board of Directors and shall act as follows:

      (1)   shall determine the Company's business development and plans of
activity, the principles for financing the prioritization thereof;

                                       13
<PAGE>

      (2)   shall examine the Company's financial condition and set the
Company's credit framework;

      (3)   shall determine the manpower organizational structure and the wages
policy;

      (4)   shall have the right to decide on the issuance of debentures or
series thereof;

      (5)   is responsible for the preparation and approval of the financial
reports as described in Section 171(b) and 171(c) of the Law;

      (6)   shall report to the Annual Meeting about the state of the Company's
affairs and its business results, all as described in Section 173 of the Law;

      (7)   shall appoint and dismiss the General Manager, as described in
Section 250 of the Law;

      (8)   shall resolve upon acts and transactions that require its approval
in accordance with these Articles or under the provisions of Sections 255 and
258 through 275 of the Law;

      (9)   may allocate shares and securities convertible into shares up to the
limit of the Company's registered share capital, pursuant to the provisions of
Section 288 of the Law;

      (10)  may decide on a distribution as described in Section 307 of the Law;

      (11)  shall express its opinion on a special purchase offer, as described
in Section 329 of the Law.

      (b)   The powers of the Board of Directors under this Article may not be
delegated to the General Manager.

      (c)   The business of the Company shall be managed by the directors. The
Board of Directors shall be entitled to exercise all the powers and authorities
that the Company has and to perform in its name all acts that it is entitled to
do according to these Articles, its Memorandum of Association, the Law, and/or
any applicable law except for those powers which, pursuant to the Law or these
Articles, are vested in the General Meeting of the Company, or in any other
organ of the Company. However any later Article adopted by the Company in its
General Meeting shall not affect the legality of any prior act of the directors
that would be legal and valid, if not for such new Article.

      (d)   The Board of Directors may from time to time, subject to the
provisions of the Law, cause the Company to borrow or secure the payment of any
sum(s) of money for the purposes of the Company, and may secure or provide for
the repayment of such sum(s), in such manner, times and upon terms and
conditions as it deems appropriate. The Board of Directors may act in this
manner by the issuance of bonds, perpetual or redeemable debentures, debenture
shares, or any mortgages, charges or other securities on the undertaking or the
whole or any part of the Company's property, both present and future, including
its uncalled or called but unpaid capital for the time being.

                                       14
<PAGE>

MEETINGS AND RESOLUTIONS OF THE BOARD OF DIRECTORS

47.   (a) A meeting of the Board of Directors at which a quorum is present shall
be competent to exercise all the authorities, powers and discretions vested in
or exercisable by the Board of Directors.

      (b)   Majority Required. A resolution proposed at any meeting of the Board
of Directors shall be deemed adopted if approved by a majority of the Directors
present when such resolution is put to a vote, entitled to vote thereon and
voting thereon.

      (c)   Resolution in Writing. A resolution in writing signed by all
Directors then in office and lawfully entitled to vote thereon (as conclusively
determined by the Chairman of the Audit Committee and in the absence of such
determination - by the Chairman of the Barod of Directors) or to which all such
Directors have given their written consent (by letter, facsimile, e-mail
followed by an executed written instrument of confirmation or otherwise) shall
be deemed to have been unanimously adopted by a meeting of the Board of
Directors duly convened and held.

DELEGATION OF POWERS OF DIRECTORS

48.   (a) Subject to the provisions of the Law, the Board of Directors may
delegate certain of its powers to committees, each consisting of two or more
Directors, and it may from time to time revoke such delegation or alter the
composition of any such committee. Any Committee so formed (in these Articles
referred to as a "COMMITTEE OF THE BOARD OF DIRECTORS"), shall, in the exercise
of the powers so delegated, conform to any regulations imposed on it by the
Board of Directors. The meetings and proceedings of any such Committee of the
Board of Directors shall, mutatis mutandis, be governed by the provisions herein
contained for regulating the meetings of the Board of Directors, so far as they
are not superseded by any regulations adopted by the Board of Directors under
this Article.

      (b)   Unless otherwise expressly provided by the Board of Directors in
delegating powers to a Committee of the Board of Directors, such Committee shall
not be empowered to further delegate such powers.

      (c)   Notwithstanding the provisions of sub-article (a) above, the Board
of Directors shall not delegate its powers to any of its committees, on the
following matters; except for the purpose of submitting its recommendations to
the Board of Directors:

      (1)   determination of the Company's general policy(ies);

      (2)   a Distribution (as defined in the Law), other than an acquisition by
the Company of its shares in accordance with pre-approved guidelines set by the
Board of Directors;

      (3)   determining the Board of Directors' stand on a matter that requires
approval by the General Meeting, or giving an opinion as required under in
Section 329 of the Law;

      (4)   issuance of shares or of securities convertible or exercisable into
shares or the issuance of debentures or series thereof, other then the issuance
of shares pursuant to an exercise or conversion of the Company's securities;

                                       15
<PAGE>

      (5)   approval of annual financial reports;

      (6)   Board of Directors approval of transactions and acts that require
Board of Directors approval in accordance with the provisions of Sections 255
and 268 through 275 of the Law;

      (d)   Subject to the provisions of the Law and without derogating from the
provisions of Article 48, the Board of Directors may, from time to time appoint
a Secretary to the Company, as well as officers, agents, employees and
independent contractors, as the Board of Directors may deem fit, and may
terminate the service of any such person(s). The Board of Directors may further,
determine the powers and duties, as well as the salaries and emoluments, of all
such persons, and may require security in such cases and in such amounts as it
deems fit.

      (e)   The Board of Directors may from time to time, by power of attorney
or otherwise, appoint any person, company, firm or body of persons to be the
attorney or attorneys of the Company at law or in fact for such purpose(s) and
with such powers, authorities and discretions, and for such period and subject
to such conditions, as it deems fit and any such power of attorney or other
appointment may contain such provisions for the protection and convenience of
persons dealing with any such attorney as the Board of Directors may deem fit,
and may also authorize any such attorney to delegate all or any of the powers,
authorities and discretions vested in him.

DIRECTORS

49.   The Board of Directors shall be comprised of up to [three] members.

50.   (a) Subject to the provisions of Article 52 below, the directors shall be
removed or replaced by those parties entitled to appoint or elect such director.
Notice of appointment and removal shall become effective on the date fixed in
the notice of appointment or removal, or upon delivery thereof to the Company,
whichever is later. If a seat on the Board of Directors is vacated, and no one
is entitled to replace such vacated seat; then such vacated seat shall be filled
by a unanimous consent of the remaining directors, provided that no more than
three (3) directors shall be in office.

      (b)   If the office of any member of the Board of Directors is vacated the
other members of the Board of Directors may act in every way and manner, so long
as their number does not fall below the quorum, at that time, for a Board of
Directors meeting. If pursuant to the Law their number does fall below the
requisite quorum, they shall not be permitted to act except insofar as to fill
the vacant places to the Board of Directors or to convene a General Meeting.

51.   Subject to the provisions of the Law, no person shall be disqualified to
serve as a Director by reason of his not holding shares in the Company or by
reason of his having served as a Director in the past.

52.   Vacation of Office of Director. The tenure or office of a Director shall
automatically terminate upon any of the following occurrences:

      (i)   if he/she was declared bankrupt, and if he/she is a corporate body -
it has voluntarily decided upon liquidation, or a liquidation order was issued
against it;

                                       16
<PAGE>

      (ii)  if he/she is declared mentally incompetent;

      (iii) if he/she has resigned by an instrument in writing to the Company;

      (iv)  if his/her successor is appointed pursuant to Article 50 above;

      (v)   with his/her death;

      (vi)  with the liquidation of the Company;

      (vii) if he/she resigned or was dismissed as described in Sections 229,
231, or 233 of the Law.

      (viii) if he/she was convicted of an offense; as described in Section 232
of the Law; and

      (ix)  by decision of the Court as described in Section 233 of the Law.

REMUNERATION OF DIRECTORS

53.   A director shall be entitled to remuneration for his services as Director
as shall be determined by the Board of Directors. Notwithstanding the foregoing,
the Directors shall be entitled to receive expenses, board and lodgings that
have been expended for or during the performance of their duties as Directors
and including travel expenses to and from the meetings of the Board of
Directors.

CONFLICT OF INTEREST

54.   Subject to the provisions of the Law, the Company may enter into any
contract or otherwise transact any business with any Director in which contract
or business such Director has a personal interest, directly or indirectly; and
may enter into any contract or otherwise transact any business with any third
party in which contract or business a Director has a personal interest, directly
or indirectly.

ALTERNATE DIRECTOR

55.   (a) Subject to the provisions of Sections 237 and 238 of the Law, a
Director may, by written notice to the Company, appoint an alternate for himself
(in these Articles referred to as an "ALTERNATE DIRECTOR"), remove such
Alternate Director and appoint another Alternate Director in place of any
Alternate Director appointed by him whose office has been vacated for any reason
whatsoever.

      (b)   Unless the appointing Director, by the instrument appointing an
Alternate Director or by written notice to the Company, limits such appointment
to a specified period of time or restricts it to a specified meeting or action
of the Board of Directors, or otherwise restricts its scope, the appointment
shall be for an indefinite period, and for all purposes.

      (c)   Any notice given to the Company pursuant to Article 55(a) shall
become effective on the date fixed therein, or upon the delivery thereof to the
Company, whichever is later.

                                       17
<PAGE>

      (d)   An Alternate Director shall have all the rights and obligations of
the Director who appointed him, provided, however, that he may not in turn
appoint an alternate for himself (unless the instrument appointing him otherwise
expressly provides), and provided further that an Alternate Director shall have
no standing at any meeting of the Board of Directors or any committee thereof
while the Director who appointed him is present.

      (e)   Any natural person, who is not a member of the Board of Directors
and not already been nominated as a Alternate Director, may act as an Alternate
Director. One person may not act as Alternate Director for several directors.

      (f)   An Alternate Director shall alone be responsible for his own acts
and defaults, and he shall not be deemed the agent of the Director who appointed
him.

      (g)   The office of an Alternate Director shall be vacated under the
circumstances, mutatis mutandis, set forth in Article 52, and such office shall
automatically be vacated if the Director who appointed such Alternate Director
ceases to be a Director.

PROCEEDINGS OF BOARD OF DIRECTORS MEETINGS

56.   (a) The Board of Directors shall meet at least once a year and adjourn its
meetings and otherwise regulate such meetings and proceedings as the Directors
deem fit and subject to the provisions of the Law. Subject to all of the other
provisions of these Articles concerning meetings of the Board of Directors, the
Board of Directors may meet by telephone conference call so long as each
Director participating in such call can hear, and be heard by, each other
Director participating in such call.

      (b)   Any Director may at any time, and the Secretary, upon the request of
such Director, shall, convene a meeting of the Board of Directors. but not less
than two (2) business days' written notice shall be given of any meeting unless
notice is waived in writing by all of the Directors as to a particular meeting.

57.   Quorum. (a) Until otherwise decided by all of the then serving members of
the Board of Directors, a quorum at a meeting of the Board of Directors shall be
constituted by the presence (or participation by phone and/or video conference)
of a majority of the Directors then in office who are lawfully entitled to
participate in the meeting (as conclusively determined by the Chairman of the
Audit Committee and in the absence of such determination - by the Chairman of
the Board of Directors).

                                       18
<PAGE>

      (b)   If within an hour from the time appointed for the meeting a quorum
is not present, the meeting shall stand adjourned to the same time and place on
the second following business day (the "FIRST ADJOURNMENT"). The quorum required
at the First Adjournment shall be the same quorum required under sub-article
57(a) above.

      (c)   If within an hour from the time appointed for the First Adjournment
a quorum is not present, the meeting shall stand adjourned to the same time and
place on the second following business day (the "SECOND ADJOURNMENT"). The
quorum required at a Second Adjournment shall be two Directors then in office
who are lawfully entitled to participate in the meeting. At any adjournment
thereafter, the quorum required shall be the same as for the Second Adjournment.

CHAIRMAN OF THE BOARD OF DIRECTORS

58.   The Board of Directors may from time to time elect one of its members to
be the Chairman of the Board of Directors, remove such Chairman from office and
appoint another in its place. The Chairman of the Board of Directors shall
preside at every meeting of the Board of Directors, but if there is no such
Chairman, or if at any meeting he is not present within fifteen (15) minutes of
the time fixed for the meeting, or if he refuses to so preside, the Directors
present shall choose one of their members to be the chairman of such meeting.
The office of Chairman shall not, by itself, entitle the holder thereof to vote
at any General Meeting nor shall it entitle such holder to a second or casting
vote.

VALIDITY OF ACTS

59.   Subject to the provisions of the Law, all bona fide actions of the
directors at any meeting of the Board of Directors, or of a Committee of the
Board of Directors, or by any person(s) acing as Director(s), shall,
notwithstanding that it may afterwards be discovered that there was some defect
in the appointment of the participants in such meetings or any of them or any
person(s) acting as aforesaid, or that they or any of them were disqualified, be
as valid as if there were no such defect or disqualification.

GENERAL MANAGER

60.   The Board of Directors may from time to time appoint one or more persons,
whether or not Directors, as General Manager(s) of the Company and may confer
upon such person(s), and from time to time modify or revoke, such title(s)
(including Managing Director, Director General or any similar title) and such
duties and authorities of the Board of Directors as the Board of Directors may
deem fit, subject to such limitations and restrictions as the Board of Directors
may from time to time prescribe, all subject to the provisions of the Law. Such
appointment(s) may be either for a fixed term or without any limitation of time,
and the Board of Directors may from time to time (subject to the provisions of
the Law and of any contract between any such person and the Company) fix his or
their salaries and remuneration, remove or dismiss him or them from office and
appoint another or others in his or their place or places.

MINUTES

61.   (a) The directors shall cause minutes to be taken of each General Meeting,
and of each meeting of the Board of Directors or of the meetings of the
Committee(s) of the Board of Directors to

                                       19
<PAGE>

be recorded and duly entered in the Company's books provided for that purpose.
Such minutes shall, in all events, set forth the names of the persons present at
the meeting, the matters discussed at the meeting, directives given to any
Committee of the Board of Directors, that a legal quorum was present, all
resolutions adopted and if request, a reservation of a shareholder or director
with regard to a matter discussed or resolved upon.

      (b)   Any minutes as aforesaid, if signed by the chairman of the meeting
or by the chairman of the next succeeding meeting, shall constitute prima facie
evidence of the matters recorded therein.

DIVIDENDS

62.   Subject to the provisions of the Law, the Board of Directors may from time
to time declare, and cause the Company to pay, such interim dividend(s) as may
appear to the Board of Directors to be justified in light of the Company's
profits and financial situation. The final dividend in respect of any fiscal
period shall be recommended by the Board of Directors and shall be payable only
after the same has been approved by Ordinary Resolution in a General Meeting,
but no such resolution shall provide for the payment of an amount exceeding the
recommended by the Board of Directors as final dividend(s), and no such
resolution or any failure to approve a final dividend shall affect any interim
dividend previously declared and paid. The Board of Directors shall determine
the time for payment of such dividends, both interim and final, and the record
date for determining the shareholders entitled thereto.

63.   Funds Available for Payment of Dividends. No dividend shall be paid
otherwise than out of the profits of the Company.

64.   No dividend shall carry interest as against the Company.

65.   Payment in Specie. Upon the recommendation of the Board of Directors
approved by Ordinary Resolution in a General Meeting, a dividend may be paid,
wholly or partly, by the distribution of specific assets of the Company or by
distribution of paid up shares, debentures or debenture stock of the Company or
of any other companies, or in any one or more of such ways.

66.   Capitalization of Profits, Reserves, etc. Upon the recommendation of the
Board of Directors approved by Ordinary Resolution of the Company, the Company

      (a)   may cause any moneys, investments, or other assets forming part of
the undivided profits of the Company, standing to the credit of a reserve fund,
or to the credit of a reserve fund for the redemption of capital, or in the
hands of the Company and available for dividends, or representing premiums
received on the issuance of shares and standing to the credit of the share
premium account, to be capitalized and distributed among such of the
shareholders as would be entitled to receive the same if distributed by way of
dividend and in the same proportion, on the footing that they become entitled
thereto as capital, or may cause any part of such capitalized fund to be applied
on behalf of such shareholders in paying up in full, either at par or at premium
as the resolution may provide, any unissued shares or debentures or debenture
shares of the Company which shall be distributed accordingly, in payment, in
full or in part, of the uncalled liability on any issued shares or debentures or
debenture shares; and

                                       20
<PAGE>

      (b)   may cause such distribution or payment to be accepted by such
shareholders in full satisfaction of their intent in the said capitalized sum.

67.   Implementation of Powers Under Articles 65 and 66. For the purpose of
giving full effect to any resolution under Articles 65 and 66, the Board of
Directors may settle any difficulty which may arise with respect to the
distribution as it deems expedient, and, in particular, may fix the value for
distribution of any specific assets, and may determine that cash payments shall
be made to any shareholders upon the footing of the value so fixed, or that
fraction of less value than the nominal value of one share may be disregarded in
order to adjust the rights of all parties, and may vest any such cash, shares,
debentures, debenture shares or specific assets in trustees upon such trusts for
the persons entitled to the dividend or capitalized fund as may seem expedient
to tree Board of Directors.

Where required according to the provisions of the Law, a proper contract shall
be executed and the Board of Directors may appoint any person to sign such
contract on behalf of the persons entitled to the dividend or capitalized fund.

68.   RESERVED.

69.   RESERVED

70.   Unclaimed Dividends. All unclaimed dividends or other moneys payable in
respect of a share may be invested or otherwise made use of by the Board of
Directors for the benefit of the Company until claimed. The payment by the
Directors of any unclaimed dividend or such other moneys into a separate account
shall not constitute the Company a trustee in respect thereof, and any dividend
unclaimed after a period of two (2) years from the date of declaration of such
dividend, and any such other moneys unclaimed after a like period from the date
the same were payable, shall be forfeited and shall revert to the Company,
provided, however, that the Board of Directors may, in its discretion, cause the
Company to pay any such dividend or such other moneys, or any part thereof, to a
person who would have been entitled thereto had the same not reverted to the
Company.

71.   Mechanics of Payment. Any dividend or other moneys payable in cash in
respect of a share may be paid by check or warrant sent through the post to, or
left at, the registered address of the person entitled thereto or by transfer to
a bank account specified by such person (or, if two or more persons are
registered as joint holders of such share or are entitled jointly thereto in
consequence of the death or bankruptcy of the holder or otherwise, to any one of
such persons or to his bank account), or to such person and at such address as
the person entitled thereto may by writing direct. Every such check or warrant
shall be made payable to the order of the person to whom it is sent, or to such
person as the person entitled thereto as aforesaid may direct, and payment of
the check or warrant by the banker upon whom it is drawn shall be a good
discharge to the Company. Every such check or warrant shall be sent at the risk
of the person entitled to the money represented thereby.

72.   Receipt from a Joint Holder. If two or more persons are registered as
joint holders of any share, or are entitled jointly thereto in consequence of
the death or bankruptcy of the holder or otherwise, any one of them may give
binding receipts for any dividend or other moneys payable or property
distributable in respect of such share.

ACCOUNTS AND AUDIT

                                       21
<PAGE>

73.   Books of Account. The Board of Directors shall cause accurate books of
account to be kept in accordance with the provisions of the Law and of any other
applicable law. Such books of account shall be kept at the registered office of
the Company, or at such other place or places as the Board of Directors may deem
fit, and they shall always be open to inspection by all Directors.

74.   Audit. At least once in every fiscal year the accounts of the Company
shall be audited and the correctness of the profit and loss account and balance
sheet certified by one or more duly qualified auditors.

75.   Auditors. The appointment, authorities, rights and duties of the
auditor(s) of the Company, shall be regulated by applicable law, provided,
however, that in exercising its authority to fix the remuneration of the
auditor(s), the shareholders in General Meeting may, in an Ordinary Resolution,
authorize (and in the absence of any such authorization or similar action in
connection therewith shall be deemed to have so authorized or acted) the Board
of Directors to fix such remuneration subject to such criteria or standards, if
any, as may be provided in such Ordinary Resolution, and if no such criteria of
standards are so provided, such remuneration shall be fixed in an amount
commensurate with the volume and nature of the services rendered by such
auditor(s).

BRANCH REGISTERS

76.   Subject to and in accordance with the provisions of the Law and to all
orders and regulations issued hereunder, the Company may cause branch registers
to be kept in any place outside Israel as the Board of Directors deems
appropriate, and, subject to all applicable requirements of any law, the Board
of Directors may from time to time adopt such rules and procedures as it may
deem appropriate in connection with the keeping of such branch registers.

RIGHTS OF SIGNATURE AND STAMP

77.   (a) The Board of Directors shall be entitled to authorize any person(s)
(who need not be Directors) to act and sign on behalf of the Company, and the
acts and signature(s) of such person(s) on behalf of the Company shall bind the
Company insofar as such person(s) acted and signed within the scope of his or
their authority.

      (b)   The Company shall have one official rubber stamp. The directors
shall cause such stamp to be kept in a safe place.

      (c)   The printing of the name of the Company or by a typewriter or by
hand next to the signatures of the authorized signatories of the Company, shall
be valid as if the rubber stamp of the Company was affixed.

NOTICES

78.   A notice or any other document may be served by the Company upon any
shareholder either personally or by sending it by email and facsimile addressed
to such member at his address, whenever situated, as appearing in the register
of shareholders.

79.   RESERVED.

                                       22
<PAGE>

80.   Prior and timely notice of the convening of a shareholders meeting shall
be given to each shareholder, wherever situated, at the last address provided by
the shareholder. Any shareholder registered in the register who shall, from time
to time, furnish the Company with an address at which notices may be served,
shall be entitled to receive all notices he is entitled to receive according to
these Articles at that address.

81.   A notice may be given by the Company to the persons entitled to a share in
consequence of the death or bankruptcy of a shareholder by sending it through
the post in a prepaid letter or postcard or facsimile or email followed by a
confirming facsimile addressed and to them by name, at the address, if any, in
Israel furnished for the purpose by the persons claiming to be so entitled or,
until such an address has been so furnished, by giving the notice in any manner
in which the same might have been given if the death or bankruptcy had not
occurred.

82.   Any notice or other document if served or sent by post shall be deemed to
have been served or delivered ten (10) days after the time when the letter or
postcard containing the same was delivered to the post or at such time as the
facsimile was sent or in case of an email then at such time as the facsimile
confirming such email was sent, and in proving such service it shall be
sufficient to prove that the letter or postcard or facsimile or email followed
by a confirming facsimile containing the notice was properly addressed and
delivered at the post office or sent by facsimile or email followed by
confirming facsimile. Any list kept in the ordinary manner in any mail list of
the Company or any copy of any email or facsimile in the Company's possession
shall be prima facie proof of the delivery.

83.   In any case where it is necessary to give prior notice of a certain number
of days or a notice valid for a certain period, the date of delivery shall be
taken into account in the number of days or period.

INSURANCE AND INDEMNITY

84.   (a) Exemption From Duty Of Care. Subject to the provisions of the Law,
including the receipt of all approvals as required therein or under any
applicable law, the Company may resolve in advance to exempt as "office holder"
(as such term is defined in the Law) from all or part of such officer holder's
responsibility or liability for damages caused to the Company due to any breach
of such office holder's duty of care towards the Company.

      (b)   Indemnification.

            (i)   Subject to the provisions of the Law, including the receipt of
all approvals as required therein or under any applicable law, the Company may
indemnify or enter into an agreement to indemnify in the future any office
holder to the fullest extent permitted by the Law.

            (ii)  Subject to the provisions of the Law, including the receipt of
all approvals as required therein or under any applicable law, the Company may
resolve retroactively to indemnify an office holder with respect to the
following liabilities and expenses, provided that such liabilities or expenses
were incurred by such office holder in such office holder's capacity as an
office holder of the Company:

                                       23
<PAGE>

                  (1)   a monetary liability imposed on an office holder
                  pursuant to a judgment in favor of another person, including a
                  judgment imposed on such office holder in a compromise or in
                  an arbitration decision that was approved by a court of law;
                  and

                  (2)   reasonable legal expenses, including attorney's fees,
                  which the office holder incurred or with which he was charged
                  by a court of law, in a proceeding brought against him, by the
                  Company or by another in its name, or in a criminal
                  prosecution in which the officer holder was acquitted, or in a
                  criminal prosecution in which he was convicted of an offense
                  that does not require proof of criminal intent.

            (iii) Subject to the provisions of the Law, including the receipt of
all approvals as required therein or under any applicable law, the Company may
resolve in advance to indemnify the Company's office holders for those
liabilities and expenses described in sub-article 83(b)(ii)(2), provided that:
(a) in the opinion of the Board of Directors such liabilities and expenses can
be foreseen at the time the undertaking to indemnify is provided, and (b) the
Board of Directors shall set a reasonable limit to the amounts for such
indemnification under the circumstances.

      (c)   Insurance.

            (i)   Subject to the provisions of the Law, including the receipt of
all approvals as required therein or under any applicable law, the Company may
enter into an agreement to insure an office holder to the maximal extent
permitted under law, for any liability that may be imposed on such office holder
in connection with an act performed by such office holder in such office
holder's capacity as an officer holder of the Company, with respect to each of
the following:

                  (1)   breach of the duty of care of the office holder towards
                  the Company or towards another person;

                  (2)   breach of the fiduciary duty towards the Company,
                  provided that the office holder acted in good faith and with
                  reasonable grounds to assume that the action in question would
                  not cause harm to the Company; and

                  (3)   a monetary obligation imposed on the office holder for
                  the benefit of another person.

            (ii)  Articles 83(a), 83(b) and 83(c)(i) shall not apply under any
of the following circumstances:

                  (1)   a breach of an office holder's fiduciary duty, in which
                  the office holder did not act in good faith and did not have
                  reasonable grounds to assume that the action in question would
                  not cause harm to the Company;

                  (2)   a grossly negligent or intentional violation of an
                  office holder's duty of care.

                  (3)   an intentional action by an office holder in which such
                  office holder intended to illegally obtain a personal gain;
                  and

                  (4)   a fine or ransom levied on an office holder.

                                       24
<PAGE>

            (iii) The Company may procure insurance for or indemnify any person
who is not an office holder, including without limitation, any employee, agent,
consultant or contractor, provided, however, that any such insurance or
indemnification is in accordance with the provisions of these Articles and the
Law.

                                       25
<PAGE>

                                   EXHIBIT 6.2

                               CLOSING CONDITIONS

6.2(iv) THIRD PARTY CONSENTS, ASSIGNMENTS AND RELEASES

      -     Cancellation of all outstanding Predix options and warrants, as
            required

      -     Assignment of Ramot license

      -     Assignment of Astra Zeneca agreements

6.2(v) POST-CLOSING AGREEMENTS

      -     Michael Kauffman Employment Agreement

      -     Loan and Pledge Agreements with each of Silvia Noiman, Oren Becker
            and Haim Aviv

      -     Warrant to GE Capital

6.2(vi) FORM OF INDEMNIFICATION (ATTACHED HERETO)

<PAGE>

                                                                   June 30, 2003

Physiome Sciences, Inc.
150 College Road West
Suite 300
Princeton, New Jersey 08540-6604
USA

Dear Sirs:

1.    Each of the undersigned, OrbiMed Associates LLC, Caduceus Private
      Investments LP and PW Juniper Crossover Fund L.L.C. (each, an "OrbiMed
      Entity") hereby agrees and undertakes to indemnify you and hold you
      harmless from any Israeli capital gains taxes (including interest,
      linkage, penalties, fines and directly related reasonable attorneys and/or
      accounting fees (together "Taxes")) which you shall pay in connection with
      Israeli withholding tax obligations related to your acquisition of such
      OrbiMed Entity's shares in Predix Pharmaceuticals Ltd., in accordance with
      the Agreement to Purchase All of the Capital Stock of Predix
      Pharmaceuticals Ltd. dated June 30, 2003 (the "Purchase Agreement").

2.    You hereby agree to notify us promptly, in writing to the undersigned at:
      767 Third Avenue, 30th Floor New York, NY 10017 (or to such address as we
      may advise you in writing) of any tax withholding demand you may receive
      (a "Demand"), and to cooperate with us with regard to such Demand. It is
      hereby specifically clarified that the indemnification set forth in
      Section 1 above is conditioned upon your consent not to take any action
      relating to such Demand unless agreed to, by us, in advance.

3.    The indemnification under this letter is specifically limited to any Taxes
      actually paid by you to the Israeli tax Authorities as set forth herein.

4.    This letter is given solely to Physiome Sciences, Inc. and is neither
      transferable nor assignable to any third party.

5.    This letter shall expire upon the sixth anniversary of the closing date of
      the Purchase Agreement. Notwithstanding the foregoing, in case you receive
      a Demand prior to the expiration date, our obligation under Section 1
      above, shall survive the expiration of the letter.

______________________
OrbiMed Associates LLC
By:_________________

_______________________________
Caduceus Private Investments LP
By:_________________

________________________________
PW Juniper Crossover Fund L.L.C.
By:________________<PAGE>

                                                                   EXHIBIT 10.18

                                                                  Execution Copy

                             PHYSIOME SCIENCES, INC.

                           CONVERTIBLE PREFERRED STOCK

                                AGREEMENT OF SALE

                            DATED AS OF JULY 1, 2003

<PAGE>

                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                                Page No.
                                                                                --------
<S>                                                                             <C>
1. Authorization; Sale of Shares...............................................     1

   1.1      Authorization......................................................     1
   1.2      Sale of Securities.................................................     1
   1.3      Agreement of Purchase..............................................     2
   1.4      Options and Warrants of The Company................................     2

2. The Closing.................................................................     3

3. Representations of the Company..............................................     3

   3.1      Organization and Standing..........................................     3
   3.2      Subsidiaries, Etc..................................................     4
   3.3      Capitalization.....................................................     5
   3.4      Issuance of Securities.............................................
   3.5      Authority for Agreement; No Conflict...............................     5
   3.6      Governmental Consents..............................................     6
   3.7      Litigation.........................................................     6
   3.8      Financial Statements...............................................     7
   3.9      Absence of Undisclosed Liabilities.................................     7
   3.10     Absence of Changes.................................................     7
   3.11     Taxes..............................................................     7
   3.12     Property and Assets................................................     8
   3.13     Intellectual Property..............................................     8
   3.14     Insurance..........................................................    10
   3.15     Material Contracts and Obligations.................................    10
   3.16     Compliance.........................................................    11
   3.17     Employees..........................................................    11
   3.18     ERISA..............................................................    13
   3.19     Books and Records..................................................    13
   3.20     Permits............................................................    13
   3.21     Environmental Matters..............................................    13
   3.22     Disclosures........................................................    14

4. Representations of the Purchasers...........................................    15

   4.1      Investment.........................................................    15
   4.2      Authority..........................................................    15
   4.3      Experience.........................................................    15

5. Transfer of Shares..........................................................    15

   5.1      Restricted Shares..................................................    15
   5.2      Requirements for Transfer..........................................    15
   5.3      Legend.............................................................    16

6. Company Conduct Prior to Closing and Conditions to Closing; Termination.....    16
</TABLE>

                                      -i-
<PAGE>

                                          TABLE OF CONTENTS

<TABLE>
<CAPTION>                                                                       Page No.
                                                                                --------
<S>                                                                             <C>

   6.1      Company Conduct Prior to Closing...................................    16
   6.2      Conditions to Closing..............................................    17
   6.3      Termination........................................................    17

7. Miscellaneous...............................................................    18

   7.1      Successors and Assigns.............................................    18
   7.2      Survival of Representations and Warranties.........................    18
   7.3      Brokers............................................................    18
   7.4      Severability.......................................................    18
   7.5      Specific Performance...............................................    18
   7.6      Governing Law; Jurisdiction........................................    18
   7.7      Notices............................................................    19
   7.8      Complete Agreement.................................................    19
   7.9      Amendments and Waivers.............................................    19
   7.10     Required Disclosures...............................................    20
   7.11     Pronouns...........................................................    20
   7.12     Counterparts; Facsimile Signatures.................................    20
   7.13     Section Headings and References....................................    20
</TABLE>

                                      -ii-
<PAGE>

                                    EXHIBITS

Exhibit A - List of Purchasers and Securities Purchased

Exhibit B - Financing Signature Page

Exhibit C - Amended and Restated Certificate of Incorporation of Physiome
Sciences, Inc.

Exhibit D - Stockholders Agreement

Exhibit E - Transaction Warrant

Exhibit F - Funding Warrant

Exhibit G - Exceptions to Representations

                                     -iii-
<PAGE>

                             PHYSIOME SCIENCES, INC.

                  CONVERTIBLE PREFERRED STOCK AGREEMENT OF SALE

      This Agreement, dated as of July 1, 2003, is entered into by and among
Physiome Sciences, Inc., a Delaware corporation (the "Company"), Predix
Pharmaceuticals, Ltd., a corporation formed under the laws of Israel ("Predix
Ltd."), Predix Pharmaceuticals, Inc., a Delaware company and a wholly owned
subsidiary of Predix Ltd. ("Predix Inc." and together with Predix Ltd.,
"Predix") and the individuals and entities listed on Exhibit A hereto who become
parties to this Agreement by executing and delivering a financing signature page
in the form of Exhibit B hereto (the "Purchasers"), or such other form as may be
acceptable to the Company (the "Financing Signature Page"). In consideration of
the mutual promises and covenants contained in this Agreement, the parties
hereto agree as follows:

      1. Authorization; Sale of Shares.

            1.1 Authorization. The Company has, or before the Closing (as
defined in Section 2) will have, duly authorized for the sale and issuance of
such securities pursuant to the terms of this Agreement, of 2,500,000 shares of
a newly authorized Series B Convertible Preferred Stock, $.01 par value per
share (the "Series B Preferred Stock"), having the rights, privileges,
preferences and restrictions set forth in the Amended and Restated Certificate
of Incorporation attached hereto as Exhibit C (the "Certificate of
Incorporation"), 1,100,000 shares of a newly authorized Series A Convertible
Preferred Stock, $.01 par value per share (the "Series A Preferred Stock"),
having the rights, privileges, preferences and, restrictions set forth in the
Certificate of Incorporation, 40,000,000 shares of Common Stock, par value $.01
per share (the "Common Stock"), having the rights, privileges, preferences and
restrictions set forth in the Certificate of Incorporation, and 4,400,000 shares
of a newly authorized Class A Common Stock, par value $.01 per share (the "Class
A Common Stock"), having the rights, privileges, preferences and restrictions
set forth in the Certificate of Incorporation. The Company has, or before the
Closing will have, adopted and, will, simultaneous with the Closing, file the
Certificate of Incorporation with the Secretary of State of the State of
Delaware. Such Series B Preferred Stock and Series A Preferred Stock is separate
and distinct from the Company's authorized Series B Convertible Preferred Stock
issued and outstanding immediately prior to Closing (the "Prior Series B
Preferred Stock") and the Company's authorized Series A Convertible Preferred
Stock issued and outstanding immediately prior to Closing (the "Prior Series A
Preferred Stock"), which classes of Prior Series B Preferred Stock and Prior
Series A Preferred Stock shall not survive the Closing.

            1.2 Sale of Securities. Subject to the terms and conditions of this
Agreement, at the Closing, the Company will sell and issue to each of the
Purchasers, and each of the Purchasers will purchase, the number of shares of
Series B Preferred Stock, the number of shares of Series A Preferred Stock, the
number of shares of Common Stock, the number of Transaction Warrants, as
hereinafter defined, and the number of Funding Warrants, as hereinafter defined,
set forth opposite such Purchaser's name on Exhibit A for the aggregate purchase
consideration set forth opposite each Purchaser's name on Exhibit A (all such
consideration having an aggregate fair market value of $US7,710,000), which
consideration shall be payable in Preferred Shares of Predix Ltd. and/or
Ordinary Shares of Predix Ltd. transferred to the Company pursuant to the

                                      -1-
<PAGE>

Purchase Agreement, as defined below (the "Purchase Price"). The shares of
Series B Preferred Stock, Series A Preferred Stock and the shares of Common
Stock sold under this Agreement are referred to herein as the "Shares" and,
together with the Transaction Warrants and the Funding Warrants, are referred to
herein as the "Securities.

            1.3 Agreement of Purchase. The parties hereto each acknowledge and
agree that: (i) the Closing shall occur simultaneous with and shall be
conditioned upon the closing of the transactions contemplated by that certain
Physiome Sciences, Inc. Agreement to Purchase All of the Capital Stock of Predix
Pharmaceuticals, Ltd., of even date herewith (the "Purchase Agreement"); and
(ii) that the Purchase Price herein shall be offset in full against the Purchase
Price (as defined in the Purchase Agreement) to be paid by the Company in
accordance with the Purchase Agreement.

            1.4 Options and Warrants of The Company. At the Closing, all
outstanding options and warrants to purchase shares of the Company's Capital
Stock shall remain outstanding or shall be canceled and reissued, as reflected
on the post Closing capitalization table attached hereto as Exhibit G, and in
each such case shall be adjusted as and if necessary to reflect the revised
capital structure of the Company as set forth in the Certificate of
Incorporation.

      2. The Closing. Subject to the terms and conditions of this Agreement, the
closing (the "Closing") of the sale and purchase of the Securities under this
Agreement shall take place at the offices of Hale and Dorr LLP, 650 College Road
East, 4 Floor, Princeton, New Jersey 08540 (or remotely via the exchange of
documents and signatures) on the date that is three (3) business days after the
satisfaction or waiver of all of the conditions to the obligations of the
parties to consummate the transactions contemplated hereby (the "Closing Date").
At the Closing the following transactions shall occur, which transactions shall
be deemed to take place simultaneously and no transaction shall be deemed to
have been completed or any document delivered until all such transactions have
been completed and all such documents delivered:

                  (a) the Company and the Purchasers shall execute and deliver
(by means of the Financing Signature Page) the Stockholders Agreement in the
form attached hereto as Exhibit D (the "Stockholders Agreement");

                  (b) the Company shall deliver to the Purchasers certificates,
as of the most recent practicable dates, (i) as to the corporate good standing
of the Company issued by the Secretary of State of the State of Delaware and
(ii) as to the due qualification of the Company as a foreign corporation issued
by the Secretary of State of New Jersey;

                  (c) the Company shall deliver to the Purchasers the
Certificate of Incorporation of the Company as amended and in effect as of the
Closing Date certified by the Secretary of State of the State of Delaware, which
Certificate of Incorporation shall be in the form attached hereto as Exhibit C;

                  (d) the Company shall deliver to the Purchasers a Certificate
of the Secretary of the Company attesting as to (i) the By-laws of the Company;
(ii) the signatures and titles of the officers of the Company executing this
Agreement or any of the other agreements to be executed and delivered by the
Company at the Closing; and (iii) resolutions of the Board of Directors and
stockholders of the Company, authorizing and approving all matters in connection
with this Agreement and the transactions contemplated hereby;

                                      -2-
<PAGE>

                  (e) the Company shall deliver to each of the Purchasers a
certificate for the number of Securities set forth opposite such Purchaser's
name on Exhibit A, registered in the name of such Purchaser;

                  (f) the Company shall deliver to each of the Purchasers that
number of Transaction Warrants set forth opposite such Purchaser's name on
Exhibit A, and in the form attached hereto as Exhibit H;

                  (g) the Company shall deliver to each of the Purchasers that
number of Funding Warrants set forth opposite such Purchaser's name on Exhibit
A, and in the form attached hereto as Exhibit I;

                  (h) each Purchaser shall tender to the Company, the Purchase
Price for the Securities being purchased from the Company. The Closing shall not
be deemed to occur, and all such payments by any Purchaser shall be deemed to be
held in escrow, until all Purchasers listed on Exhibit A have tendered to the
Company the payment indicated thereon; and

                  (i) a duly executed Purchase Agreement shall be delivered to
each of the parties hereto.

      3. Representations of the Company. Except as disclosed by the Company in
Exhibit G hereto, the Company hereby represents and warrants to each Purchaser
that the statements contained in this Section 3 are complete and accurate as of
the date of this Agreement. Exhibit G shall be arranged in sections
corresponding to the numbered and lettered sections and subsections contained in
this Section 3, and the disclosures in any section or subsection of Exhibit G
shall qualify only the corresponding section or subsection of this Section 3,
unless otherwise specified.

            3.1 Organization and Standing. The Company is a corporation duly
organized, validly existing and in good standing under the laws of the State of
Delaware and has full corporate power and authority to conduct its business as
presently conducted and as proposed to be conducted by it and to enter into and
perform this Agreement and all other agreements required to be executed by the
Company at or prior to the Closing pursuant to Section 2 (the "Ancillary
Agreements") and to carry out the transactions contemplated by this Agreement
and the Ancillary Agreements. The Company is duly qualified to do business as a
foreign corporation and is in good standing in the State of New Jersey and in
every other jurisdiction in which the failure so to qualify would have a
material adverse effect on the business, prospects, assets or condition
(financial or otherwise) of the Company (a "Company Material Adverse Effect").
The Company has furnished to the Purchasers complete and accurate copies of its
Certificate of Incorporation and By-laws, each as amended to date and presently
in effect and as in effect immediately upon the Closing. The Company has at all
times complied with all provisions of its Certificate of Incorporation and
By-laws and is not in default under, or in violation of, any such provision.

            3.2 Subsidiaries, Etc. The Company has no subsidiaries and does not
own or control, directly or indirectly, any shares of capital stock of any other
corporation or any interest in any partnership, limited liability company, joint
venture or other non-corporate business enterprise.

                                      -3-
<PAGE>

            3.3 Capitalization.

                  (a) The authorized capital stock of the Company (immediately
prior to the Closing) consists of (i) 40,000,000 shares of Common Stock, $.01
par value per share (the "Existing Common Stock"), of which 3,665,354 shares are
issued and outstanding and no shares are held in the treasury of the Company,
and (ii) 21,469,982 shares of Preferred Stock, $.01 par value per share, of
which 43,745 shares have been designated as Series A Convertible Preferred
Stock, all of which are issued or outstanding; 6,060,606 shares have been
designated as Series B Convertible Preferred Stock, all of which are issued or
outstanding; 3,883,377 shares have been designated as Series C Convertible
Preferred Stock, 2,568,371 of which are issued or outstanding; 10,438,413 shares
have been designated as Series D Convertible Preferred Stock, all of which are
issued or outstanding; and 1,043,841 shares have been designated as Series E
Convertible Preferred Stock, none of which are outstanding.

                  (b) Exhibit G includes a complete and accurate list, as of the
date of the Agreement, of the holders of capital stock of the Company, showing
the number of shares of capital stock and other equity securities of the
Company, and the class or series of such shares and equity securities, held by
each stockholder and the number of shares of Existing Common Stock (if any) into
which such shares and equity securities are, convertible, both immediately prior
to and immediately following the Closing. None of such outstanding shares and
equity securities constitute restricted stock or are otherwise subject to a
repurchase or redemption right. All of the issued and outstanding shares of
capital stock of the Company have been duly authorized and validly issued and
are fully paid and nonassessable. All of the issued and outstanding shares of
capital stock of the Company have been offered, issued and sold by the Company
in compliance with all applicable federal and state securities laws.

                  (c) Exhibit G includes a complete and accurate list, as of the
date of this Agreement of, and sets forth information both immediately prior to
and immediately following the Closing with respect to: (i) all stock option
plans and other stock or equity-related plans of the Company (the "Company Stock
Plans"), indicating for each Company Stock Plan the number of shares of Existing
Common Stock issued to date under such Company Stock Plan, the number of shares
subject to outstanding options under such Company Stock Plan and the number of
shares reserved for future issuance under such Company Stock Plan; (ii) all
holders of outstanding options to purchase shares of Existing Common Stock
("Company Stock Options"), indicating with respect to each Company Stock Option
the Company Stock Plan under which it was granted, the number of shares of
Existing Common Stock subject to such Company Stock Option, the exercise price,
the date of grant, and the vesting schedule (including any acceleration
provisions with respect thereto); and (iii) all holders of warrants or other
rights (other than Company Stock Options and outstanding convertible preferred
stock) to purchase or acquire shares of capital stock of the Company ("Company
Warrants"), indicating with respect to each Company Warrant the agreement or
other document under which it was granted, the number of shares of capital
stock, and the class or series of such shares, subject to such Company Warrant,
the exercise price, the date of issuance and the expiration date thereof. The
Company has furnished to the Purchasers complete and accurate copies of all
Company Stock Plans, forms of all stock option agreements evidencing all Company
Stock Options and all Company Warrants. All of the shares of capital stock of
the Company subject to Company Stock Options and Company Warrants will be, upon
issuance pursuant to the exercise of such instruments, duly authorized, validly
issued, fully paid and nonassessable.

                                      -4-
<PAGE>

                  (d) Except as set forth in this Section 3.3 or Exhibit G, upon
closing: (i) no subscription, warrant, option, convertible security or other
right (contingent or otherwise) to purchase or acquire any shares of capital
stock of the Company is authorized or outstanding, (ii) the Company has no
obligation (contingent or otherwise) to issue any subscription, warrant, option,
convertible security or other such right, or to issue or distribute to holders
of any shares of its capital stock any evidences of indebtedness or assets of
the Company, (iii) the Company has no obligation (contingent or otherwise) to
purchase, redeem or otherwise acquire any shares of its capital stock or any
interest therein or to pay any dividend or to make any other distribution in
respect thereof, and (iv) there are no outstanding or authorized stock
appreciation, phantom stock or similar rights with respect to the Company.

                  (e) Except as set forth in Exhibit G, and except for the
Ancillary Agreements and agreements that will be cancelled at Closing, there is
no agreement, written or oral, between the Company and any holders of its
securities, or, to the best of the Company's knowledge, among any holder of its
securities, relating to the sale or transfer (including without limitation
agreements relating to rights of first refusal, co-sale rights or "drag-along"
rights), registration under the Securities Act of 1933, as amended (the
"Securities Act"), or voting, of the capital stock of the Company.

                  (f) Upon the filing of the Certificate of Incorporation with
the Secretary of State of the State of Delaware: (i) each outstanding share of
the Company's existing Preferred Stock immediately prior to Closing shall be
duly exchanged into shares of Series A Preferred Stock or Series B Preferred
Stock on the terms set forth in and having the rights and preferences set forth
in the Certificate of Incorporation; and (ii) the reverse stock split
recapitalization of the Company's Capital Stock shall be immediately effective
and of full force and effect. Subject only to receipt of all requisite
stockholder approval, the Company has taken all requisite corporate action
necessary to file the Certificate of Incorporation with the Secretary of State
of the State of Delaware.

            3.4 Issuance of Securities. The issuance, sale and delivery of the
Securities in accordance with this Agreement, and the issuance and delivery of
the shares of Preferred Stock or Common Stock issuable upon conversion of the
Securities and the shares of Common Stock underlying such Preferred Stock, have
been, or will be on or prior to the Closing (or in the case of shares of capital
stock to be issued upon the conversion of the Funding Warrant (the "Future
Shares"), will be, at such time or times as such Funding Warrants may be
converted), duly authorized by all necessary corporate action on the part of the
Company, and all such shares have been (or, in the case of the Future Shares,
will be) duly reserved for issuance. The Shares when so issued, sold and
delivered against payment therefor in accordance with the provisions of this
Agreement, and the shares of Preferred Stock and Common Stock issuable upon
conversion of the Securities and the shares of Common Stock underlying such
Preferred Stock when issued upon such conversion, will be duly and validly
issued, fully paid and nonassessable and, except as set forth in the Ancillary
Agreements, and except, with respect to the Funding Warrants which may be
subject to any and all terms and conditions to be determined without the consent
of the Purchasers at the time of their exercise, are free and clear from any
third party right whatsoever.

            3.5 Authority for Agreement; No Conflict. The execution, delivery
and performance by the Company of this Agreement and the Ancillary Agreements,
and the consummation by the Company of the transactions contemplated hereby and
thereby, have been duly authorized by all necessary corporate action. This
Agreement has been, and the Ancillary Agreements when executed at the Closing
will be, duly executed and delivered by the Company

                                      -5-
<PAGE>

and constitute valid and binding obligations of the Company enforceable in
accordance with their respective terms, subject as to enforcement of remedies to
applicable bankruptcy, insolvency, reorganization, moratorium or similar laws
affecting generally the enforcement of creditors' rights and subject to a
court's discretionary authority with respect to the granting of a decree
ordering specific performance or other equitable remedies. The execution and
delivery of this Agreement and the Ancillary Agreements, the consummation of the
transactions contemplated hereby and thereby and the compliance with their
respective provisions by the Company will not (a) conflict with or violate any
provision of the Certificate of Incorporation or By-laws of the Company, (b)
require on the part of the Company any filing with, or any permit, order,
authorization, consent or approval of any court, arbitrational tribunal,
administrative agency or commission or other governmental or regulatory
authority or agency (each of the foregoing is hereafter referred to as a
"Governmental Entity") other than the filing of the Certificate of Incorporation
with the Secretary of State of the State of Delaware, as provided for under
Section 3.3(f) above, (c) conflict with, result in a breach of, constitute (with
or without due notice or lapse of time or both) a default under, result in the
acceleration of obligations under, create in any party the right to accelerate,
terminate, modify or cancel, or require any notice, consent or waiver under, any
contract, lease, sublease, license, sublicense, franchise, permit, indenture,
agreement or mortgage for borrowed money, instrument of indebtedness, Security
Interest (as defined below) or other arrangement to which the Company is a party
or by which the Company is bound or to which its assets are subject, other than
any of the foregoing events listed in this clause (c) which do not and will not,
individually or in the aggregate, have a Company Material Adverse Effect, (d)
result in the imposition of any Security Interest upon any assets of the Company
or (e) violate any order, writ, injunction, decree, statute, rule or regulation
applicable to the Company or any of its properties or assets. For purposes of
this Agreement, "Security Interest" means any mortgage, pledge, security
interest, encumbrance, charge, or other lien (whether arising by contract or by
operation of law).

            3.6 Governmental Consents. No consent, approval, order or
authorization of, or registration, qualification, designation, declaration or
filing with, any Governmental Entity is required on the part of the Company in
connection with the offer, issuance, sale and delivery of the Securities, the
issuance and delivery of the shares of Preferred Stock or Common Stock issuable
upon conversion of the Securities, the shares of Common Stock underlying such
Preferred Stock, or the other transactions to be consummated at the Closing, as
contemplated by this Agreement and the Ancillary Agreements, except such filings
as shall be made prior to and shall be effective on and as of the Closing and
such filings required to be made after the Closing under applicable federal and
state securities laws, all of which filings are specified in Exhibit G. Based on
the representations made by each of the Purchasers in Section 4 of this
Agreement, the offer and sale of the Securities to each of the Purchasers will
be in compliance with applicable United States federal and state securities
laws.

            3.7 Litigation. There is no action, suit or proceeding, or
governmental inquiry or investigation, pending, or, to the best of the Company's
knowledge, any basis therefor or threat thereof, against the Company, which
questions the validity of this Agreement, the Ancillary Agreements or the right
of the Company to enter into any such agreements, or which might result, either
individually or in the aggregate, in a Company Material Adverse Effect. There is
no litigation pending, or, to the best of the Company's knowledge, any basis
therefor or threat thereof, against the Company, or any of its employees by
reason of the past employment relationships of any of the employees, the
proposed activities of the Company, or negotiations by the Company with possible
investors in the Company. The Company is not subject to any outstanding
judgment, order or decree.

                                      -6-
<PAGE>

            3.8 Financial Statements. The Company has furnished to each of the
Purchasers a complete and accurate copy of (i) the audited balance sheet of the
Company at December 31, 2002 and the related audited statements of operations
and cash flows for the fiscal year then ended, and (ii) the unaudited balance
sheet of the Company (the "Balance Sheet") at April 30, 2003 (the "Balance Sheet
Date") and the related statements of operations and cash flows for the three
months then ended, (collectively, the "Financial Statements"). The Financial
Statements are in accordance with the books and records of the Company, present
fairly the financial condition and results of operations of the Company, at the
dates and for the periods indicated, and have been prepared in accordance with
generally accepted accounting principles ("GAAP") consistently applied, except
that the unaudited Financial Statements may not be in accordance with GAAP
because of the absence of footnotes normally contained therein and are subject
to normal year-end audit adjustments which in the aggregate will not be
material.

            3.9 Absence of Undisclosed Liabilities. The Company does not have
any liability (whether known or unknown and whether absolute or contingent),
except for (a) liabilities shown on the Balance Sheet, (b) liabilities not in
excess of $10,000 in the aggregate, which have arisen since the Balance Sheet
Date in the ordinary course of business and which are similar in nature and
amount to the liabilities which arose during the comparable period of time in
the immediately preceding fiscal period and (c) contractual liabilities incurred
in the ordinary course of business which are not required by GAAP to be
reflected on a balance sheet and which would not, either individually or in the
aggregate, have or result in a Company Material Adverse Effect.

            3.10 Absence of Changes. Since the Balance Sheet Date, there has
been no material adverse change in the business, prospects, condition (financial
or otherwise), or results of operations of the Company, other than changes
occurring in the ordinary course of business (which ordinary course changes have
not, individually or in the aggregate, had a Company Material Adverse Effect).

            3.11 Taxes.

                  (a) "Taxes" shall mean all taxes or other similar assessments
or liabilities, including without limitation, income, gross receipts, ad
valorem, premium, value-added, excise, real property, personal property, assets,
sales, use, transfer, withholding, employment, unemployment, insurance, social
security, business license, business organization, environmental, workers
compensation, payroll, profits, license, lease, service, service use, severance,
stamp, occupation, windfall profits, customs, duties, franchise, net worth,
capital stock, gains and other taxes imposed by the United States, or any state,
local or foreign government, or any agency thereof, or other political
subdivision of the United States or any such government, and any interest,
fines, penalties, assessments or additions to tax resulting from, attributable
to or incurred in connection with any tax or any contest or dispute thereof.
"Tax Returns" shall mean all reports, returns, declarations, statements or other
information required to be filed with a taxing authority in connection with
Taxes.

                  (b) The Company has paid all Taxes due and payable by the
Company on or before the date hereof. Management believes that the unpaid Taxes
of the Company do not exceed the reserve for actual Taxes (as opposed to any
reserve for deferred Taxes established to reflect timing differences between
book and Tax income) as shown on the Balance Sheet.

                                      -7-
<PAGE>

                  (c) The Company has timely filed or has obtained presently
effective extensions (which extensions, if any, are listed on Exhibit G) with
respect to all federal, state, local and foreign Tax Returns which are required
to be filed by it, such returns are complete and accurate and all Taxes shown
thereon to be due have been timely paid. The Company has not explicitly waived
any statute of limitation with respect to any Tax or agreed to any extension of
time with respect to a Tax assessment or deficiency. The Tax Returns of the
Company have not been under audit or examination by the Internal Revenue Service
or other relevant taxing authority, and no controversy with respect to Taxes of
any type is pending or, to the best of the Company's knowledge, threatened.

                  (d) The Company has withheld or collected from each payment
made to its employees, independent contractors, stockholders, creditors and
other third parties the amount of all Taxes required to be withheld or collected
therefrom and has paid all such amounts to the appropriate taxing authorities
when due. To the Company's knowledge, it has complied with all information
reporting requirements including maintenance of the required records with
respect thereto in connection with amounts paid to any employee, independent
contractor, stockholder, creditor or other third party.

                  (e) To the Company's knowledge, there are no liens for Taxes
upon the Company's assets, other than liens for ad valorem Taxes not yet due and
payable.

                  (f) The Company has disclosed on its federal income Tax
Returns all positions taken therein that could give rise to a substantial
understatement of federal income Tax within the meaning of Section 6662 of the
Code.

                  (g) The Company has not distribution stock of another
corporation nor has its stock been distributed by another corporation in a
transaction that was purported or intended to be governed in whole or in part by
Section 355 or Section 361 of the Code.

                  (h) The Company's net operating losses for federal income Tax
purposes, as set forth in the Financial Statements, are not subject to any
limitations imposed by Section 382 of the Code.

                  (i) The Company is not a party to or member of any joint
venture, partnership, or other arrangement or contract which could be treated as
a partnership for federal, state, local or foreign income Tax purposes.

            3.12 Property and Assets. The Company has good title to, or a valid
leasehold interest in, all of its material properties and assets, including all
properties and assets reflected in the Balance Sheet, except those disposed of
since the date thereof in the ordinary course of business, and none of such
properties or assets is subject to any Security Interest other than those the
material terms of which are described in the Balance Sheet or in Exhibit G.

            3.13 Intellectual Property.

                  (a) Exhibit G lists (i) each patent, patent application,
copyright registration or application therefor, mask work registration or
application therefor, and trademark, service mark and domain name registration
or application therefor of the Company and (ii) each Customer Deliverable (as
defined below) of the Company.

                                      -8-
<PAGE>

                  (b) The Company owns or has the right to use all Intellectual
Property (as defined below) necessary (i) to use, manufacture, market and
distribute the Customer Deliverables and (ii) to operate the Internal Systems
(as defined below). The Company has taken all reasonable measures to protect the
proprietary nature of each item of Company Intellectual Property (as defined
below), and to maintain in confidence all trade secrets and confidential
information, that it owns or uses. No other person or entity has any rights to
any of the Company Intellectual Property owned by the Company (except pursuant
to agreements or licenses specified in Exhibit G), and, to the best of the
Company's knowledge, no other person or entity is infringing, violating or
misappropriating any of the Company Intellectual Property.

                  (c) None of the Customer Deliverables, or the marketing,
distribution, provision or use thereof, infringes or violates, or constitutes a
misappropriation of, any Intellectual Property rights of any person or entity;
and neither the marketing, distribution, provision or use of any Customer
Deliverables currently under development by the Company will, when such Customer
Deliverables are commercially released by the Company, infringe or violate, or
constitute a misappropriation of, any Intellectual Property rights of any person
or entity that exist today. None of the Internal Systems, or the use thereof,
infringes or violates, or constitutes a misappropriation of, any Intellectual
Property rights of any person or entity. Exhibit G lists any complaint, claim or
notice, or written threat thereof, received by the Company alleging any such
infringement, violation or misappropriation; and the Company has provided to the
Purchasers complete and accurate copies of all written documentation in the
possession of the Company relating to any such complaint, claim, notice or
threat. The Company has provided to the Purchasers complete and accurate copies
of all written documentation in the Company's possession relating to claims or
disputes known to the Company concerning any Company Intellectual Property.

                  (d) Exhibit G identifies each license or other agreement
pursuant to which the Company has licensed, distributed or otherwise granted any
rights to any third party with respect to, any Company Intellectual Property.
Except as described in Exhibit G, the Company has not agreed to indemnify any
person or entity against any infringement, violation or misappropriation of any
Intellectual Property rights with respect to any Company Intellectual Property.

                  (e) Exhibit G identifies each item of Company Intellectual
Property that is owned by a party other than the Company, and the license or
agreement pursuant to which the Company uses it (excluding off-the-shelf
software programs licensed by the Company pursuant to "shrink wrap" licenses).

                  (f) The Company has not disclosed the source code for any
software developed by it, or other confidential information constituting,
embodied in or pertaining to such software, to any person or entity, except
pursuant to the agreements listed in Exhibit G, and the Company has taken
reasonable measure to prevent disclosure of such source code.

                  (g) All of the copyrightable materials incorporated in or
bundled with the Customer Deliverables have been created by employees of the
Company within the scope of their employment by the Company or by independent
contractors of the Company who have executed agreements expressly assigning all
right, title and interest in such copyrightable materials to the Company. No
portion of such copyrightable materials was jointly developed with any third
party.

                                      -9-
<PAGE>

                  (h) The Customer Deliverables and the Internal Systems are
free from significant defects or programming errors and conform in all material
respects to the written documentation and specifications therefor.

                  (i) For purposes of this Agreement, the following terms shall
have the following meanings:

                        (i) "Customer Deliverables" shall mean (a) the products
that the Company (i) currently manufactures, markets, sells or licenses or (ii)
currently plans to manufacture, market, sell or license in the future and (b)
the services that the Company (i) currently provides or (ii) currently plans to
provide in the future.

                        (ii) "Internal Systems" shall mean the internal systems
of the Company that are used in its business or operations, including, computer
hardware systems, software applications and embedded systems.

                        (iii) "Intellectual Property" shall mean all: (a)
patents, patent applications, patent disclosures and all related continuation,
continuation-in-part, divisional, reissue, reexamination, utility model,
certificate of invention and design patents, patent applications, registrations
and applications for registrations; (b) trademarks, service marks, trade dress,
Internet domain names, logos, trade names and corporate names and registrations
and applications for registration thereof; (c) copyrights and registrations and
applications for registration thereof; (d) mask works and registrations and
applications for registration thereof; (e) computer software, data and
documentation; (f) inventions, trade secrets and confidential business
information, whether patentable or nonpatentable and whether or not reduced to
practice, know-how, manufacturing and product processes and techniques, research
and development information, copyrightable works, financial, marketing and
business data, pricing and cost information, business and marketing plans and
customer and supplier lists and information; (g) other proprietary rights
relating to any of the foregoing (including remedies against infringements
thereof and rights of protection of interest therein under the laws of all
jurisdictions); and (h) copies and tangible embodiments thereof.

                        (iv) "Company Intellectual Property" shall mean the
Intellectual Property owned by or licensed to the Company and incorporated in,
underlying or used in connection with the Customer Deliverables or the Internal
Systems.

            3.14 Insurance. The Company maintains valid policies of workers'
compensation insurance and of insurance with respect to its directors and
officers and its properties and business of the kinds and in the amounts as the
management believes is suitable for companies engaged in the same or similar
business and similarly situated, including, without limitation, insurance
against loss, damage, fire, theft, public liability and other risks.

            3.15 Material Contracts and Obligations. Exhibit G sets forth a list
of all material agreements or commitments of any nature (whether written or
oral) to which the Company is a party or by which it is bound, including without
limitation (a) any agreement which requires future expenditures by the Company
in excess of $10,000 in the aggregate or which might result in payments to the
Company in excess of $10,000 in the aggregate, (b) any employment and consulting
agreements, employee benefit, bonus, pension, profit-sharing, stock option,
stock purchase and similar plans and arrangements, (c) any distributor, sales
representative or similar agreement, (d) any agreement with any current or
former stockholder, officer or director of the Company, or any "affiliate" or
"associate" of such persons (as such

                                      -10-
<PAGE>

terms are defined in the rules and regulations promulgated under the Securities
Act), including without limitation any agreement or other arrangement providing
for the furnishing of services by, rental of real or personal property from, or
otherwise requiring payments to, any such person or entity, (e) any agreement
under which the Company is restricted from carrying on any business anywhere in
the world, (f) any agreement relating to indebtedness for borrowed money, (g)
any agreement for the disposition of a material portion of the Company's assets
(other than for the sale of inventory in the ordinary course of business), (h)
any agreement for the acquisition of the business or securities or other
ownership interests of another party or (i) any other agreement that is material
to the operations, business or finances of the Company. The Company has
delivered to the Purchasers copies of the foregoing agreements (or an accurate
summary of any oral agreement). All of such agreements and contracts are valid,
binding and in full force and effect. Neither the Company, nor, to the best of
the Company's knowledge, any other party thereto, is in default of any of its
obligations under any of the agreements or contracts listed on Exhibit G, in a
manner which could have a Company Material Adverse Effect.

            3.16 Compliance. The Company has, in all material respects, complied
with all laws, regulations and orders applicable to its present and proposed
business and has all material permits and licenses required thereby. There is no
term or provision of any mortgage, indenture, contract, agreement or instrument
to which the Company is a party or by which it is bound, or, to the best of the
Company's knowledge, of any provision of any state or federal judgment, decree,
order, statute, rule or regulation applicable to or binding upon the Company,
which materially adversely affects or, so far as the Company may now foresee, in
the future is reasonably likely to result in or have a Company Material Adverse
Effect. To the best of the Company's knowledge, no employee of the Company is in
violation of any term of any contract or covenant (either with the Company or
with another entity) relating to employment, patents, assignment of inventions,
proprietary information disclosure, non-competition or non-solicitation.

            3.17 Employees.

                  (a) All current and former employees of the Company have
executed and delivered non-disclosure and assignment of inventions agreements
and all of such agreements are in full force and effect and shall remain in full
force and effect following the closing. All current and former employees of the
Company have executed and delivered non-competition and non-solicitation
agreements and all of such agreements are in full force and effect and shall
remain in full force and effect following the closing. All current and former
independent contractors of the Company that have performed development work or
provided technical services to the Company or have otherwise had access to
confidential or proprietary information of the Company have executed and
delivered non-disclosure and assignment of inventions agreements, copies of
which have been delivered to the Purchasers, and all of such agreements are in
full force and effect and shall remain in full force and effect following the
closing.

                  (b) The Company is not aware that any employee of the Company
that the Company has requested remain employed subsequent to the Closing who has
plans to terminate his or her employment relationship with the Company. All
employees of the Company are engaged by the Company on a full time basis. The
Company has complied in all material respects with all applicable laws relating
to wages, hours, equal opportunity, collective bargaining, workers' compensation
insurance and the payment of social security and other taxes. None of the
employees of the Company is represented by any labor union, and there is no
labor strike or other labor trouble pending with respect to the Company
(including, without limitation,

                                      -11-
<PAGE>

any organizational drive) or, to the best of the Company's knowledge,
threatened. Exhibit G sets forth a list of all agreements between any officer of
the Company and a previous employer of such person that contains non-competition
or non-solicitation covenants. The Company has delivered copies of such
agreements to the Purchasers. No employee of the Company is obligated under any
contract or subject to any judgment, decree or administrative order that would
conflict or interfere with (i) the performance of the employee's duties as an
employee, director or officer of the Company, or (ii) the Company's business as
conducted or proposed to be conducted.

                  (c) The Company has provided to Predix a list of the salaries
and any bonus arrangements of each employee and independent contractor of the
Company. Such list of all employees of the Company is accurate as of the date of
this Agreement, and correctly reflects, in all material respects, their salaries
and terms and conditions of employment, any other compensation payable to them
(including compensation payable pursuant to bonus, deferred compensation or
commission arrangements, vacation pay balances, illness pay balances, and fringe
benefits including, without limitation, balances in pension funds, car,
telephone, or managers insurance), their dates of employment and their positions
and ranks (if any).

                  (d) The Company is not a party to any collective bargaining
contract or other contract with a labor union involving any of its employees.

                  (e) Other than the personal employment agreements referred to
in Exhibit G, there are no employment, severance or similar agreements or offer
letters, whether written or unwritten, between the Company and any of its
respective directors, officers, executives or employees which cannot be
terminated by the Company upon thirty (30) days notice without giving rise to a
claim for damages or compensation (except for statutory severance pay).

                  (f) As of the date hereof, there are no pending, or to the
knowledge of the Company threatened, or reasonably anticipated, claims or
actions outstanding against the Company by any person who is now or has been an
officer or employee of the Company, and there have been no material disputes
between the Company and any material number or category of employees. Further,
the Company is not aware of any formal or informal complaints by any employee of
the Company of any wrongdoing which could be construed as a complaint of
discrimination, workplace harassment or wrongful employment-related action or
inaction.

                  (g) The statutory and contractual overtime, severance pay,
accrued vacation, and any other employment-related benefits due to employees of
the Company as of the Closing is either funded or provided for in the Financial
Statements. No cause of action exists giving right to employees to any claim for
compensation for overtime or termination severance pay to which such employee is
entitled and to the knowledge of the Company, no such claims will be made by any
employee for payment of any compensation or provision of any right or benefit as
a result of the transactions contemplated hereby.

                  (h) The Company is not liable for any material arrears of
wages or any penalty for failure to comply with the foregoing.

                  (i) The Company is not liable for any payment to any trust or
other fund governed by or maintained by or on behalf of any governmental
authority, with respect to unemployment compensation benefits, social security
or other benefits or obligations for

                                      -12-
<PAGE>

Employees (other than routine payments to be made in the normal course of
business and consistent with past practice).

                  (j) All amounts which the Company is legally or contractually
required to deduct from its employees' salaries and/or transfer to such
employees' pension, life insurance, incapacity insurance, continuing education
fund or otherwise have been duly paid into the appropriate fund or funds, and
the Company has no outstanding obligation to make any such transfer or provision
on account of overdue payments.

            3.18 ERISA. Exhibit G hereto lists all employee benefit plans (as
defined in Section 3(3) of the Employee Retirement Income Security Act of 1974,
as amended ("ERISA")) maintained by the Company. Each of such employee benefit
plans complies in all material respects with (i) all applicable requirements of
ERISA and (ii) all applicable requirements of the Code.

            3.19 Books and Records. The minute books of the Company contain
complete and accurate records of all meetings and other corporate actions of its
stockholders and its Board of Directors and committees thereof. The stock ledger
of the Company is complete and accurate and reflects all issuances, transfers,
repurchases and cancellations of shares of capital stock of the Company.

            3.20 Permits. Exhibit G sets forth a list of all material permits,
licenses, registrations, certificates, orders or approvals from any Governmental
Entity ("Permits") issued to or held by the Company. Such listed Permits are the
only Permits that are required for the Company to conduct its business as
presently or currently expected to be conducted, except for those the absence of
which would not have a Company Material Adverse Effect. Each such Permit is in
full force and effect and, to the best of the Company's knowledge, no suspension
or cancellation of such Permit is threatened and there is no basis for believing
that such Permit will not be renewable upon expiration.

            3.21 Environmental Matters.

                  (a) The Company has complied with all applicable Environmental
Laws (as defined below), except for violations of Environmental Laws that,
individually or in the aggregate, have not had and would not reasonably be
expected to have a Company Material Adverse Effect. There is no pending or, to
the best of the Company's knowledge, threatened civil or criminal litigation,
written notice of violation, formal administrative proceeding, or investigation,
inquiry or information request by any Governmental Entity, relating to any
Environmental Law involving the Company. For purposes of this Agreement,
"Environmental Law" shall mean any federal, state or local law, statute, rule or
regulation or the common law relating to the environment or occupational health
and safety, including any statute, regulation, administrative decision or order
pertaining to (i) treatment, storage, disposal, generation and transportation of
industrial, toxic or hazardous materials or substances or solid or hazardous
waste; (ii) air, water and noise pollution; (iii) groundwater and soil
contamination; (iv) the release or threatened release into the environment of
industrial, toxic or hazardous materials or substances, or solid or hazardous
waste, including emissions, discharges, injections, spills, escapes or dumping
of pollutants, contaminants or chemicals; (v) the protection of wild life,
marine life and wetlands, including all endangered and threatened species; (vi)
storage tanks, vessels, containers, abandoned or discarded barrels and other
closed receptacles; (vii) health and safety of employees and other persons; and
(viii) manufacturing, processing, using, distributing,

                                      -13-
<PAGE>

treating, storing, disposing, transporting or handling of materials regulated
under any law as pollutants, contaminants, toxic or hazardous materials or
substances or oil or petroleum products or solid or hazardous waste. As used
above, the terms "release" and "environment" shall have the meaning set forth in
the federal Comprehensive Environmental Response, Compensation and Liability Act
of 1980, as amended ("CERCLA").

                  (b) The Company has no liabilities or obligations arising from
the release of any Materials of Environmental Concern (as defined below) into
the environment. For purposes of this Agreement, "Materials of Environmental
Concern" shall mean any chemicals, pollutants or contaminants, hazardous
substances (as such term is defined under CERCLA), solid wastes and hazardous
wastes (as such terms are defined under the Resource Conservation and Recovery
Act), toxic materials, oil or petroleum and petroleum products or any other
material subject to regulation under any Environmental Law.

                  (c) The Company is not a party to or bound by any court order,
administrative order, consent order or other agreement between the Company and
any Governmental Entity entered into in connection with any legal obligation or
liability arising under any Environmental Law.

                  (d) The Company is not aware of any material environmental
liability of any solid or hazardous waste transporter or treatment, storage or
disposal facility that has been used by the Company.

                  (e) Set forth in Exhibit G is a list of all documents (whether
in hard copy or electronic form) that contain any environmental reports,
investigations and audits relating to premises currently or previously owned or
operated by the Company (whether conducted by or on behalf of the Company or a
third party, and whether done at the initiative of the Company or directed by a
Governmental Entity or other third party) which the Company has possession of or
access to. A complete and accurate copy of each such document has been provided
to the Purchasers.

            3.22 Disclosures. Neither this Agreement nor any Exhibit hereto, nor
any Ancillary Agreement nor any report, certificate or instrument furnished to
any of the Purchasers or their counsel in connection with the transactions
contemplated by this Agreement, including without limitation the Stockholder
Information Statement of the Company dated July 1, 2003 (the "Stockholder
Information Statement"), when read together, contains or will contain any untrue
statement of a material fact or omits or will omit to state a material fact
necessary in order to make the statements contained herein or therein, in light
of the circumstances under which they were made, not misleading. Each projection
furnished in the Stockholder Information Statement was prepared in good faith
based on reasonable assumptions and represents the Company's best estimate of
future results based on information available as of the date of the Stockholder
Information Statement.

                                      -14-
<PAGE>

      4. Representations of the Purchasers. Each of the Purchasers severally and
not jointly represents and warrants to the Company as follows:

            4.1 Investment. Such Purchaser is acquiring the Securities, and the
shares of Preferred Stock or Common Stock into which the Securities may be
converted and the shares of Common Stock underlying such Preferred Stock, for
his, her or its own account for investment and not with a view to, or for sale
in connection with, any distribution thereof, nor with any present intention of
distributing or selling the same; and, except as contemplated by this Agreement
and the Exhibits hereto, such Purchaser has no present or contemplated
agreement, undertaking, arrangement, obligation, indebtedness or commitment
providing for the disposition thereof. Such Purchaser is an "accredited
investor" as defined in Rule 501(a) under the Securities Act.

            4.2 Authority. Such Purchaser has full power and authority to enter
into and to perform this Agreement and the Ancillary Agreements in accordance
with their terms. Any Purchaser which is a corporation, limited liability
company, partnership or trust represents that it has not been organized,
reorganized or recapitalized specifically for the purpose of investing in the
Company.

            4.3 Experience. Such Purchaser has carefully reviewed the
representations concerning the Company contained in this Agreement, has read the
Stockholder Information Statement and has made detailed inquiry concerning the
Company, its business and its personnel; the officers of the Company have made
available to such Purchaser any and all written information which he, she or it
has requested and have answered to such Purchaser's satisfaction all inquiries
made by such Purchaser; and such Purchaser has sufficient knowledge and
experience in finance and business that he, she or it is capable of evaluating
the risks and merits of his, her or its investment in the Company and such
Purchaser is able financially to bear the risks thereof.

      5. Transfer of Shares.

            5.1 Restricted Shares. "Restricted Shares" means (i) the Securities,
(ii) the shares of Preferred Stock or Common Stock issued or issuable upon
conversion of the Securities and the shares of Common Stock underlying such
Preferred Stock, and (iii) any other shares of capital stock of the Company
issued in respect of such shares (as a result of stock splits, stock dividends,
reclassifications, recapitalizations, or similar events).

            5.2 Requirements for Transfer.

                  (a) Restricted Shares shall not be sold or transferred unless
either (i) they first shall have been registered under the Securities Act, or
(ii) the Company first shall have been furnished with an opinion of legal
counsel, reasonably satisfactory to the Company, to the effect that such sale or
transfer is exempt from the registration requirements of the Securities Act.

                  (b) Notwithstanding the foregoing, no such sale or transfer
shall be permitted unless such sale or transfer is also in compliance with all
of the terms and further restrictions on sale or transfer set forth in the
Stockholders Agreement.

                                      -15-
<PAGE>

            5.3 Legend. Each certificate representing Restricted Shares shall
bear a legend substantially in the following form:

                  "The shares represented by this certificate have not been
                  registered under the Securities Act of 1933, as amended, and
                  may not be offered, sold or otherwise transferred, pledged or
                  hypothecated unless and until such shares are registered under
                  such Act or an opinion of counsel satisfactory to the Company
                  is obtained to the effect that such registration is not
                  required."

      6. Company Conduct Prior to Closing and Conditions to Closing;
Termination.

            6.1 Company Conduct Prior to Closing. From the date hereof through
and including the earlier of the date of the Closing or the termination of this
Agreement, the Company will operate its business in a manner consistent with
prior practice and will maintain the goodwill of its clients, employees and
other persons with which it has commercial dealings.

      In addition, The Company agrees that, except as otherwise agreed to in
writing by the Company, from the date hereof through the earlier of the date of
the Closing or the termination of this Agreement:

                  (a) There will not be any increases in salary or other
payments, disbursements or distributions in any manner or form to stockholders,
members, directors, officers, employees or current independent contractors (or
related parties thereto) of the Company or affiliated or related entities, or
changes in the cash or cash equivalent accounts of the Company, other than
normal and necessary transactions in the ordinary course of business of the
Company;

                  (b) Revenue and accounts receivable will be maintained on a
normal basis and there will be no changes in methods or procedures for billing,
collection or recording of client accounts receivable relating to the business
of the Company;

                  (c) All normal and recurring installments of bank debt,
leases, contractual obligations and other amounts due third parties, if any,
will be made in the ordinary course of business and as they become due;

                  (d) There will be no new bank debt, leases, loans,
encumbrances, liens, attachments, contractual obligations or other indebtedness,
except in the ordinary course of business, nor openings of new accounts nor
amendments of signatory powers except as agreed by Predix; and

                  (e) There will not be any hiring of additional employees by
the Company without the express written consent of Predix, except for the
replacement of terminated employees. If there are any new employees hired by
either party in accordance with the foregoing sentence, such party shall notify
the other party in writing and such notice shall include the name of the
employee and the terms of employment.

      Notwithstanding any provision set forth in this Section 6. 1, the Company
retains the right and ability: (A) to license (whether on an exclusive or
non-exclusive basis), sell or transfer, subject only to the approval of the
Company's Board of Directors: (i) the Company's CMIS Drug

                                      -16-
<PAGE>

platform to Aukland or its affiliates; (ii) the Company's HUBIMS platform to PA
Consulting or its affiliates; (iii) the Company's Cell Editor and CardioPrism
technologies to Oxsoft or its affiliates; (iv) the Company's CardioPrism and
Pathway Prism technologies to any third party; and (v) the Company's Model Based
Assay Intellectual Property and work product to any third party; and (B) to
terminate any or all of its employees prior to Closing, as shall be approved by
the Company's Board of Directors in its sole discretion.

            6.2 Conditions to Closing. (a) At or prior to Closing the Company
shall have provided evidence to Predix, which evidence must be satisfactory to
Predix in its sole discretion that:

                        (i) Each of (i) that certain Voting Agreement, dated as
of October 12, 1995 and as amended on October 31, 1997, by and among the Company
and the Stockholders (as defined therein) (the "Voting Agreement"); and (ii)
that certain Registration Rights Agreement dated as of October 31, 1997, and as
amended on May 13, 1999 and May 16, 2000, by and among the Company and the
Investors (as defined therein) (the "Registration Rights Agreement") shall have
been duly terminated and of no further force and effect.

                  (b) As promptly as practicable after the execution of the
Agreement, the Company shall use its commercially reasonable efforts to, in
accordance with the Delaware General Corporation Law and the Company's
Certificate of Incorporation and Bylaws, obtain the approval, by vote or written
consent of the Company's stockholders (the "Stockholder Approval") for the
filing with the Secretary of State of the State of Delaware of Physiome's
Amended and Restated Certificate of Incorporation, in the form attached hereto;
and

                  (c) As of the Closing:

                        (i) No temporary restraining order, preliminary or
permanent injunction or other order (whether temporary, preliminary or
permanent) issued by any court of competent jurisdiction, or other legal
restraint or prohibition shall be in effect which prevents the consummation of
the transactions contemplated by this Agreement, nor shall any proceeding
seeking any of the foregoing be pending.

                        (ii) The representation and warranties of each party to
this Agreement contained herein shall be true and correct in all material
respects, except for those which are qualified as to materiality, which shall be
true and correct in all respects.

                        (iii) All parties to this Agreement shall have performed
or complied in all respects with all agreements and covenants required to be
performed or complied with by such party by this Agreement.

            6.3 Termination. In the event that: (i) any of the Conditions to
Closing set forth in Section 6.2(a) hereof are not satisfied in full, or waived
by Predix in its sole discretion; (ii) the Condition to Closing set forth in
Section 6.2(b) hereof is not satisfied in full; (iii) any of the Conditions to
Closing set forth in Section 6.2(c) hereof are not satisfied in full, or waived
by (a) both the Company and Predix with respect to Section 6.2(c)(i) or (b) the
Company or Predix, as the case may be with respect to the other party's
representations, warranties, agreements and covenants, with respect to Sections
6.2(c)(ii) and (iii); or (iv) the Purchase Agreement is terminated, then all of
the provisions of this Agreement shall terminate and there shall be no liability
on the part of any party hereto; provided, however, the provisions of Section
7.6 shall survive such termination. Notwithstanding anything to the contrary
contained herein, if the

                                      -17-
<PAGE>

Closing does not occur on or before July 31, 2003, unless such time period is
extended by mutual agreement of both Predix and Physiome, this Agreement shall
automatically terminate and shall have no further force and effect; provided,
however, the provisions of Section 7.6 shall survive such termination. If the
Agreement is terminated under this Section 6.3, the parties shall walk away from
this transaction and each party shall bear its own costs and expenses. Neither
party shall have a claim against the other party in respect with this
contemplated transaction and/or the negotiations that have preceded it.

      7. Miscellaneous.

            7.1 Successors and Assigns. This Agreement, and the rights and
obligations of the Company hereunder, may be assigned by the Company to any
affiliate, partner, member, stockholder or subsidiary of the Company. No
Purchaser may assign his, her or its rights under this Agreement.

            7.2 Survival of Representations and Warranties. None of the
representations and warranties contained herein shall survive the Closing except
such representations and warranties as set forth in Section 3.1, Section 3.2,
Section 3.3, Section 3.4, Section 3.5, Section 4. 1, Section 4.2, and Section
4.3, which representations and warranties shall survive in perpetuity.

            7.3 Brokers. Except as set forth in Exhibit B to the Purchase
Agreement, the Company, Predix and each Purchaser: (i) represents and warrants
to the other parties hereto that he, she or it has not retained a finder or
broker in connection with the transactions contemplated by this Agreement; and
(ii) will indemnify and save the other parties harmless from and against any and
all claims, liabilities or obligations with respect to brokerage or finders'
fees or commissions, or consulting fees in connection with the transactions
contemplated by this Agreement asserted by any person on the basis of any
statement or representation alleged to have been made by such indemnifying
party.

            7.4 Severability. The invalidity or unenforceability of any
provision of this Agreement shall not affect the validity or enforceability of
any other provision of this Agreement.

            7.5 Specific Performance. In addition to any and all other remedies
that may be available at law in the event of any breach of this Agreement, each
Purchaser shall be entitled to specific performance of the agreements and
obligations of the Company hereunder and to such other injunctive or other
equitable relief as may be granted by a court of competent jurisdiction.

            7.6 Governing Law; Jurisdiction. This Agreement shall be governed by
and construed in accordance with the internal laws of the State of Delaware
(without reference to the conflicts of law provisions thereof). Each of the
parties hereto: (a) submits to the jurisdiction of any state or United States
federal court sitting in the State of Delaware in any action or proceeding
arising out of or relating to this Agreement (including any action or proceeding
for the enforcement of any arbitral award made in connection with any
arbitration of a dispute hereunder), (b) agrees that all claims in respect of
such action or proceeding may be heard and determined in any such court, (c)
waives any claim of inconvenient forum or other challenge to venue in such
court, (d) agrees not to bring any action or proceeding arising out of or
relating to this Agreement in any other court and (e) waives any right it may
have to a trial by jury with respect to any action or proceeding arising out of
or relating to this Agreement. Each party hereto agrees to accept service of any
summons, complaint or other initial pleading made in the manner

                                      -18-
<PAGE>

provided for the giving of notices in Section 7.7, provided that nothing in this
Section 7.6 shall affect the right of any party to serve such summons, complaint
or other initial pleading in any other manner permitted by law

            7.7 Notices. All notices, requests, consents, and other
communications under this Agreement shall be in writing and shall be deemed
delivered (i) seven business days after being sent by registered or certified
mail, return receipt requested, postage prepaid or (ii) three business day after
being sent via a reputable international overnight courier service guaranteeing
next business day delivery, in each case to the intended recipient as set forth
below:

      If to the Company, at 150 College Road West, Suite 300, Princeton, New
Jersey 08540-6604, Attention: Chief Operating Officer, or at such other address
as may have been furnished in writing by the Company to the other parties
hereto, with a copy to Hale and Dorr LLP, 650 College Road East, 4th Floor,
Princeton, New Jersey 08540, Attention: Richard S. Mattessich, Esq.; or

      If to Predix, at 10 K Gill Street, Woburn, Massachusetts 01801, Attention:
Chief Executive Officer, or at such other address as may have been furnished in
writing by Predix to the other parties hereto, with copies to Mintz, Levin,
Cohn, Ferris, Glovsky and Popeo, P.C., One Financial Center, Boston,
Massachusetts 02111, Attention: John R. Pomerance, Esq. and Volovelsky,
Dinstein, Sneh & Co., Law Offices, Nolton House, 14 Shenkar Street, P.O. Box
12172, Herzliya-Pituach 46733, Israel, Attention: Nehama Sneh, Advocate; or

      If to a Purchaser, at its address set forth on Exhibit A, or at such other
address as may have been furnished in writing by such Purchaser to the other
parties hereto, with a copy to such Purchaser's counsel, if any, as such
Purchaser shall have notified the Company, in writing.

      Any party may give any notice, request, consent or other communication
under this Agreement using any other means (including, without limitation,
personal delivery, messenger service, telecopy, first class mail or electronic
mail), but no such notice, request, consent or other communication shall be
deemed to have been duly given unless and until it is actually received by the
party for whom it is intended. Any party may change the address to which
notices, requests, consents or other communications hereunder are to be
delivered by giving the other parties notice in the manner set forth in this
Section.

            7.8 Complete Agreement. This Agreement (including its Exhibits)
constitutes the entire agreement and understanding of the parties hereto with
respect to the subject matter hereof and supersedes all prior agreements and
understandings relating to such subject matter including, without limitation,
that certain letter of intent dated April 25, 2003.

            7.9 Amendments and Waivers. This Agreement may be amended or
terminated and the observance of any term of this Agreement may be waived with
respect to all parties to this Agreement (either generally or in a particular
instance and either retroactively or prospectively), after the Closing with the
written consent of the Company and the holders of at least 75% of the Shares
then held by all of the Purchasers or, if prior to Closing, with the Written
Consent of the Company and the holders of at least 75% of the outstanding
Preferred Shares and Ordinary Shares of Predix Ltd. constituting the Purchase
Price hereunder. Notwithstanding the foregoing, this Agreement may not be
amended or terminated and the observance of any term hereunder may not be waived
with respect to any Purchaser without the written consent of such Purchaser
unless such amendment, termination or waiver applies to all Purchasers in the
same fashion. The Company shall give prompt written notice of any amendment or
termination hereof

                                      -19-
<PAGE>

or waiver hereunder to any party hereto that did not consent in writing to such
amendment, termination or waiver. Any amendment, termination or waiver effected
in accordance with this Section 7.9 shall be binding on all parties hereto, even
if they do not execute such consent. No waivers of or exceptions to any term,
condition or provision of this Agreement, in any one or more instances, shall be
deemed to be, or construed as, a further or continuing waiver of any such term,
condition or provision.

            7.10 Required Disclosures. Each party hereto (and each employee,
representative, or other agent of such party) may disclose to any and all
persons, without limitation of any kind, the United States federal tax treatment
and tax structure of the transactions contemplated hereby and all materials of
any kind (including opinions or other tax analyses) that are provided to it
relating to such tax treatment and tax structure. For this purpose, 'tax
structure' is limited to any facts relevant to the United States federal income
tax treatment of the transaction and does not include information relating to
the identity of the parties.

            7.11 Pronouns. Whenever the context may require, any pronouns used
in this Agreement shall include the corresponding masculine, feminine or neuter
forms, and the singular form of nouns and pronouns shall include the plural, and
vice versa.

            7.12 Counterparts; Facsimile Signatures. This Agreement may be
executed in any number of counterparts (including, in the case of the
Purchasers, Financing Signature Pages), each of which shall be deemed to be an
original, and all of which shall constitute one and the same document. This
Agreement (including the Financing Signature Pages) may be executed by facsimile
signatures.

            7.13 Section Headings and References. The section headings are for
the convenience of the parties and in no way alter, modify, amend, limit or
restrict the contractual obligations of the parties. Any reference in this
agreement to a particular section or subsection shall refer to a section or
subsection of this Agreement, unless specified otherwise.

                                   ** ** ** *

                                      -20-
<PAGE>

                                    Executed as of the date first written above.

                                        PHYSIOME SCIENCES, INC.

                                        By: /s/ NIK HAYES
                                            -----------------------------------
                                            Name: Mr. Nik Hayes
                                            Title:  Chief Operating Officer
                                                     and Chief Financial Officer

                                        PREDIX PHARMACEUTICALS, LTD.

                                        By: /s/ MICHAEL KAUFFMAN
                                            -----------------------------------
                                            Name: Dr. Michael Kauffman
                                            Title: President and Chief Executive
                                                   Officer

                                        PREDIX PHARMACEUTICALS, INC.

                                        By: /s/ MICHAEL KAUFFMAN
                                            -----------------------------------
                                            Name: Dr. Michael Kauffman
                                            Title: President and Chief Executive
                                                   Officer

                                        STOCKHOLDERS OF
                                        PREDIX PHARMACEUTICALS, LTD.

                                            /s/ Illegible
                                            -----------------------------------
                                            Dr. Oren Becker, by YVC Yozma as
                                            proxy holder

                                            /s/ Illegible
                                            -----------------------------------
                                            Zvi Naor, by YVC Yozma as proxy
                                            holder

                                            /s/ Illegible
                                            -----------------------------------
                                            Silvia Noiman, by YVC Yozma as
                                            proxy holder

                                            /s/ HAIM AVIV
                                            -----------------------------------
                                            Prof. Haim Aviv

<PAGE>

                                          /s/ FREDERICK FRANK
                                        ---------------------------------------
                                        Frederick Frank

                                        RAMOT AT TEL AVIV UNIVERSITY LTD.

                                        By: /s/ Illegible
                                            -----------------------------------
                                            By YVC Yozma as proxy-holder

                                        YOZMA II(ISRAEL) LP

                                        By: /s/ Illegible
                                            -----------------------------------
                                            Name: Yigal Erlich & Chen Schor
                                            Title: Partners

                                        YOZMA MANAGEMENT AND INVESTMENT LTD.,
                                        AS TRUSTEES FOR YOZMA II(BVI) LP

                                        By: /s/ Illegible
                                            -----------------------------------
                                            Name: Yigal Erlich & Chen Schor
                                            Title: Partners

                                        PCM VENTURE CAPITAL L.P.

                                        By: /s/ Illegible
                                            -----------------------------------
                                            Name: Yigal Erlich & Chen Schor
                                            Title: Partners

                                        ORBIMED ASSOCIATES LLC

                                        By: /s/ JONATHAN SILVERSTEIN
                                            -----------------------------------
                                            Name: Jonathan Silverstein
                                            Title: Partner

                                        CADUCEUS PRIVATE INVESTMENTS LP

                                        By: /s/ JONATHAN SILVERSTEIN
                                            -----------------------------------
                                            Name: Jonathan Silverstein
                                            Title: Partner

                                        PW JUNIPER CROSSOVER FUND LLC

                                        By: /s/ JONATHAN SILVERSTEIN
                                            -----------------------------------
                                            Name: Jonathan Silverstein
                                            Title: Partner

<PAGE>

                                    EXHIBIT A

                         LIST OF SELLERS AND SHARES SOLD

<TABLE>
<CAPTION>
                                                                      AGGREGATE  AGGREGATE
                                                                      SHARES OF  SHARES OF                  MAXIMUM
                                                                       PHYSIOME  PHYSIOME     AGGREGATE    AGGREGATE   AGGREGATE
                                              NO. OF                   SERIES B  SERIES A     SHARES OF    NUMBER OF   PERCENT OF
                                   NO OF     ORDINARY   EQUIVALENT    PREFERRED  PREFERRED    PHYSIOME    TRANSACTION   FUNDING
                                 PREFERRED    SHARES   CASH PURCHASE    STOCK      STOCK    COMMON STOCK   WARRANTS     WARRANTS
  NAME AND ADDRESS OF SELLER    SHARES SOLD    SOLD        PRICE      PURCHASED  PURCHASED    PURCHASED    PURCHASED   PURCHASED(1)
  --------------------------    -----------    ----        -----      ---------  ---------  -----------   ----------   ------------
<S>                             <C>          <C>       <C>            <C>        <C>        <C>           <C>          <C>
Dr. Oren Becker................          --    24,000  $      14,692         --         --        14,692           --          --
Ramot at Tel Aviv University
Ltd............................          --    24,000  $      14,692         --         --        14,692           --          --
Zvi Naor.......................          --     4,000  $       2,448         --         --         2,448           --          --
Dr. Silvia Noiman..............          --    24,000  $      14,692         --         --        14,692           --          --
Prof. Haim Aviv................          --    24,000  $      14,692         --         --        14,692           --          --
Yozma II (Israel) LP...........   1,610,158        --  $    772,1100     17,508     59,703            --       30,491       3.05%
YVC-Yozma Management and
     Investment Ltd., as
     trustees for Yozma II
     (BVI) LP..................   2,744,594        --  $   1,316,110     29,844    101,767            --       51,974       5.20%
PCM Venture Capital LP.........   1,463,786        --  $    701,9300     15,917     54,276            --       27,719       2.77%
OrbiMed Associates  LLC........     176,636        --  $     84,6900      1,920      6,549            --        3,344       0.33%
Caduceus Private Investments
LP.............................   7,254,111        --  $   3,478,570     78,880    268,977            --      137,372      13.74%
Frederick Frank................     121,556        --  $      58,280      1,321      4,507            --        2,301       0.23%
PW Juniper Crossover Fund LLC..   2,471,433        --  $   1,185,130     26,874     91,639            --       46,801       4.68%
                                 ----------   -------  -------------  ---------    -------  ------------  -----------  ---------
         Total                   15,842,274   100,000  $   7,658,036    172,264    587,418        61,216      300,002       30.0%
                                 ==========   =======  =============  =========    =======  ============  ===========  =========
</TABLE>

--------
(1)   Represents pro-rata portion of calculation done on date of closing.

<PAGE>

                                    EXHIBIT B

                            FINANCING SIGNATURE PAGE

      By execution and delivery of this signature page, the undersigned hereby
agrees to become a Purchaser, as defined in that certain Convertible Preferred
Stock Agreement of Sale (the "Purchase Agreement") by and among Physiome
Sciences, Inc., a Delaware corporation (the "Company"), Predix Pharmaceuticals,
Ltd., a corporation formed under the laws of Israel, and the Purchasers (as
defined in the Purchase Agreement), dated as of the Closing Date (as defined in
the Purchase Agreement), acknowledges having read the representations in the
Purchase Agreement section entitled "Representations of the Purchasers," and
hereby represents that the statements contained therein are complete and
accurate with respect to the undersigned as a Purchaser. The undersigned further
hereby agrees to be bound by the terms and conditions of (i) the Purchase
Agreement as a "Purchaser" thereunder, and (ii) the Stockholders Agreement (as
defined in the Purchase Agreement) as a "Purchaser" thereunder and authorizes
this signature page to be attached to the Purchase Agreement, the Stockholders
Agreement, or counterparts thereof.

      Executed, in counterpart, as of the date set forth below.

                                        PURCHASER:

                                        By: /s/ HAIM AVIV
                                            ------------------------------------
                                            Name of Purchaser

                                        By: Haim Aviv
                                            ------------------------------------
                                        Title: _________________________________
                                        Date: 7 July 2003
                                        Contact Person: ________________________
                                        Telephone No: __________________________
                                        Telecopy No: ___________________________
                                        Email Address:

<PAGE>

                                    EXHIBIT B

                            FINANCING SIGNATURE PAGE

      By execution and delivery of this signature page, the undersigned hereby
agrees to become a Purchaser, as defined in that certain Convertible Preferred
Stock Agreement of Sale (the "Purchase Agreement") by and among Physiome
Sciences, Inc., a Delaware corporation (the "Company"), Predix Pharmaceuticals,
Ltd., a corporation formed under the laws of Israel, and the Purchasers (as
defined in the Purchase Agreement), dated as of the Closing Date (as defined in
the Purchase Agreement), acknowledges having read the representations in the
Purchase Agreement section entitled "Representations of the Purchasers," and
hereby represents that the statements contained therein are complete and
accurate with respect to the undersigned as a Purchaser. The undersigned further
hereby agrees to be bound by the terms and conditions of (i) the Purchase
Agreement as a "Purchaser" thereunder, and (ii) the Stockholders Agreement (as
defined in the Purchase Agreement) as a "Purchaser" thereunder and authorizes
this signature page to be attached to the Purchase Agreement, the Stockholders
Agreement, or counterparts thereof.

      Executed, in counterpart, as of the date set forth below.

                                        PURCHASER:

                                        By: /s/ JONATHAN SILVERSTEIN
                                            ------------------------------------
                                            OrbiMed Associates LLC

                                        By: /s/ JONATHAN SILVERSTEIN
                                            ------------------------------------
                                        Title: DIRECTOR
                                        Date: Aug. 5, 2003
                                        Contact Person: JONATHAN SILVERSTEIN
                                        Telephone No: __________________________
                                        Telecopy No: ___________________________
                                        Email Address: _________________________

<PAGE>

                                    EXHIBIT B

                            FINANCING SIGNATURE PAGE

      By execution and delivery of this signature page, the undersigned hereby
agrees to become a Purchaser, as defined in that certain Convertible Preferred
Stock Agreement of Sale (the "Purchase Agreement") by and among Physiome
Sciences, Inc., a Delaware corporation (the "Company"), Predix Pharmaceuticals,
Ltd., a corporation formed under the laws of Israel, and the Purchasers (as
defined in the Purchase Agreement), dated as of the Closing Date (as defined in
the Purchase Agreement), acknowledges having read the representations in the
Purchase Agreement section entitled "Representations of the Purchasers," and
hereby represents that the statements contained therein are complete and
accurate with respect to the undersigned as a Purchaser. The undersigned further
hereby agrees to be bound by the terms and conditions of (i) the Purchase
Agreement as a "Purchaser" thereunder, and (ii) the Stockholders Agreement (as
defined in the Purchase Agreement) as a "Purchaser" thereunder and authorizes
this signature page to be attached to the Purchase Agreement, the Stockholders
Agreement, or counterparts thereof.

      Executed, in counterpart, as of the date set forth below.

                                        PURCHASER:

                                        By: /s/ JONATHAN SILVERSTEIN
                                            ------------------------------------
                                            PW Juniper Crossover Fund, L.L.C.

                                        By: /s/ JONATHAN SILVERSTEIN
                                            ------------------------------------
                                        Title: DIRECTOR
                                        Date: Aug. 5, 2003
                                        Contact Person: JONATHAN SILVERSTEIN
                                        Telephone No: __________________________
                                        Telecopy No: ___________________________
                                        Email Address: _________________________

<PAGE>

                                    EXHIBIT B

                            FINANCING SIGNATURE PAGE

      By execution and delivery of this signature page, the undersigned hereby
agrees to become a Purchaser, as defined in that certain Convertible Preferred
Stock Agreement of Sale (the "Purchase Agreement") by and among Physiome
Sciences, Inc., a Delaware corporation (the "Company"), Predix Pharmaceuticals,
Ltd., a corporation formed under the laws of Israel, and the Purchasers (as
defined in the Purchase Agreement), dated as of the Closing Date (as defined in
the Purchase Agreement), acknowledges having read the representations in the
Purchase Agreement section entitled "Representations of the Purchasers," and
hereby represents that the statements contained therein are complete and
accurate with respect to the undersigned as a Purchaser. The undersigned further
hereby agrees to be bound by the terms and conditions of (i) the Purchase
Agreement as a "Purchaser" thereunder, and (ii) the Stockholders Agreement (as
defined in the Purchase Agreement) as a "Purchaser" thereunder and authorizes
this signature page to be attached to the Purchase Agreement, the Stockholders
Agreement, or counterparts thereof.

      Executed, in counterpart, as of the date set forth below.

                                        PURCHASER:

                                        By: /s/ JONATHAN SILVERSTEIN
                                            ------------------------------------
                                            Caduceus Private Investment, L.P.

                                        By: /s/ JONATHAN SILVERSTEIN
                                            ------------------------------------
                                        Title: DIRECTOR
                                        Date: Aug. 5, 2003
                                        Contact Person: JONATHAN SILVERSTEIN
                                        Telephone No: __________________________
                                        Telecopy No: ___________________________
                                        Email Address: _________________________

<PAGE>

                                    EXHIBIT B

                            FINANCING SIGNATURE PAGE

      By execution and delivery of this signature page, the undersigned hereby
agrees to become a Purchaser, as defined in that certain Convertible Preferred
Stock Agreement of Sale (the "Purchase Agreement") by and among Physiome
Sciences, Inc., a Delaware corporation (the "Company"), Predix Pharmaceuticals,
Ltd., a corporation formed under the laws of Israel, and the Purchasers (as
defined in the Purchase Agreement), dated as of the Closing Date (as defined in
the Purchase Agreement), acknowledges having read the representations in the
Purchase Agreement section entitled "Representations of the Purchasers," and
hereby represents that the statements contained therein are complete and
accurate with respect to the undersigned as a Purchaser. The undersigned further
hereby agrees to be bound by the terms and conditions of (i) the Purchase
Agreement as a "Purchaser" thereunder, and (ii) the Stockholders Agreement (as
defined in the Purchase Agreement) as a "Purchaser" thereunder and authorizes
this signature page to be attached to the Purchase Agreement, the Stockholders
Agreement, or counterparts thereof.

      Executed, in counterpart, as of the date set forth below.

                                        PURCHASER:

                                        By: /s/ Illegible
                                            ------------------------------------
                                            YVC Yozma Management & Investments
                                            Ltd. (as trustee for Yozma II (BVI)
                                            L.P.)

                                        By: ____________________________________
                                        Title: _________________________________
                                        Date: __________________________________
                                        Contact Person: ________________________
                                        Telephone No: __________________________
                                        Telecopy No: ___________________________
                                        Email Address: _________________________

<PAGE>

                                    EXHIBIT B

                            FINANCING SIGNATURE PAGE

      By execution and delivery of this signature page, the undersigned hereby
agrees to become a Purchaser, as defined in that certain Convertible Preferred
Stock Agreement of Sale (the "Purchase Agreement") by and among Physiome
Sciences, Inc., a Delaware corporation (the "Company"), Predix Pharmaceuticals,
Ltd., a corporation formed under the laws of Israel, and the Purchasers (as
defined in the Purchase Agreement), dated as of the Closing Date (as defined in
the Purchase Agreement), acknowledges having read the representations in the
Purchase Agreement section entitled "Representations of the Purchasers," and
hereby represents that the statements contained therein are complete and
accurate with respect to the undersigned as a Purchaser. The undersigned further
hereby agrees to be bound by the terms and conditions of (i) the Purchase
Agreement as a "Purchaser" thereunder, and (ii) the Stockholders Agreement (as
defined in the Purchase Agreement) as a "Purchaser" thereunder and authorizes
this signature page to be attached to the Purchase Agreement, the Stockholders
Agreement, or counterparts thereof.

      Executed, in counterpart, as of the date set forth below.

                                        PURCHASER:

                                        By: /s/ Illegible
                                            ------------------------------------
                                            Yozma II (Israel) L.P.

                                        By: ____________________________________
                                        Title: _________________________________
                                        Date: __________________________________
                                        Contact Person: ________________________
                                        Telephone No: __________________________
                                        Telecopy No: ___________________________
                                        Email Address: _________________________

<PAGE>

                                    EXHIBIT B

                            FINANCING SIGNATURE PAGE

      By execution and delivery of this signature page, the undersigned hereby
agrees to become a Purchaser, as defined in that certain Convertible Preferred
Stock Agreement of Sale (the "Purchase Agreement") by and among Physiome
Sciences, Inc., a Delaware corporation (the "Company"), Predix Pharmaceuticals,
Ltd., a corporation formed under the laws of Israel, and the Purchasers (as
defined in the Purchase Agreement), dated as of the Closing Date (as defined in
the Purchase Agreement), acknowledges having read the representations in the
Purchase Agreement section entitled "Representations of the Purchasers," and
hereby represents that the statements contained therein are complete and
accurate with respect to the undersigned as a Purchaser. The undersigned further
hereby agrees to be bound by the terms and conditions of (i) the Purchase
Agreement as a "Purchaser" thereunder, and (ii) the Stockholders Agreement (as
defined in the Purchase Agreement) as a "Purchaser" thereunder and authorizes
this signature page to be attached to the Purchase Agreement, the Stockholders
Agreement, or counterparts thereof.

      Executed, in counterpart, as of the date set forth below.

                                        PURCHASER:

                                        By: /s/ Illegible
                                            ------------------------------------
                                            PCM Venture Capital L.P.

                                        By: ____________________________________
                                        Title: _________________________________
                                        Date: __________________________________
                                        Contact Person: ________________________
                                        Telephone No: __________________________
                                        Telecopy No: ___________________________
                                        Email Address: _________________________

<PAGE>

                                    EXHIBIT B

                            FINANCING SIGNATURE PAGE

      By execution and delivery of this signature page, the undersigned hereby
agrees to become a Purchaser, as defined in that certain Convertible Preferred
Stock Agreement of Sale (the "Purchase Agreement") by and among Physiome
Sciences, Inc., a Delaware corporation (the "Company"), Predix Pharmaceuticals,
Ltd., a corporation formed under the laws of Israel, and the Purchasers (as
defined in the Purchase Agreement), dated as of the Closing Date (as defined in
the Purchase Agreement), acknowledges having read the representations in the
Purchase Agreement section entitled "Representations of the Purchasers," and
hereby represents that the statements contained therein are complete and
accurate with respect to the undersigned as a Purchaser. The undersigned further
hereby agrees to be bound by the terms and conditions of (i) the Purchase
Agreement as a "Purchaser" thereunder, and (ii) the Stockholders Agreement (as
defined in the Purchase Agreement) as a "Purchaser" thereunder and authorizes
this signature page to be attached to the Purchase Agreement, the Stockholders
Agreement, or counterparts thereof.

      Executed, in counterpart, as of the date set forth below.

                                        PURCHASER:

                                        By: /s/ Illegible
                                            ------------------------------------
                                            Dr. Oren Becker, by YVC Yozma as
                                            proxy holder

                                        By: ____________________________________
                                        Title: _________________________________
                                        Date: __________________________________
                                        Contact Person: ________________________
                                        Telephone No: __________________________
                                        Telecopy No: ___________________________
                                        Email Address: _________________________

<PAGE>

                                    EXHIBIT B

                            FINANCING SIGNATURE PAGE

      By execution and delivery of this signature page, the undersigned hereby
agrees to become a Purchaser, as defined in that certain Convertible Preferred
Stock Agreement of Sale (the "Purchase Agreement") by and among Physiome
Sciences, Inc., a Delaware corporation (the "Company"), Predix Pharmaceuticals,
Ltd., a corporation formed under the laws of Israel, and the Purchasers (as
defined in the Purchase Agreement), dated as of the Closing Date (as defined in
the Purchase Agreement), acknowledges having read the representations in the
Purchase Agreement section entitled "Representations of the Purchasers," and
hereby represents that the statements contained therein are complete and
accurate with respect to the undersigned as a Purchaser. The undersigned further
hereby agrees to be bound by the terms and conditions of (i) the Purchase
Agreement as a "Purchaser" thereunder, and (ii) the Stockholders Agreement (as
defined in the Purchase Agreement) as a "Purchaser" thereunder and authorizes
this signature page to be attached to the Purchase Agreement, the Stockholders
Agreement, or counterparts thereof.

      Executed, in counterpart, as of the date set forth below.

                                        PURCHASER:

                                        By: /s/ Illegible
                                            ------------------------------------
                                            Dr. Silvia Noiman, by YVC Yozma as
                                            proxy holder

                                        By: ____________________________________
                                        Title: _________________________________
                                        Date: __________________________________
                                        Contact Person: ________________________
                                        Telephone No: __________________________
                                        Telecopy No: ___________________________
                                        Email Address: _________________________

<PAGE>

                                    EXHIBIT B

                            FINANCING SIGNATURE PAGE

      By execution and delivery of this signature page, the undersigned hereby
agrees to become a Purchaser, as defined in that certain Convertible Preferred
Stock Agreement of Sale (the "Purchase Agreement") by and among Physiome
Sciences, Inc., a Delaware corporation (the "Company"), Predix Pharmaceuticals,
Ltd., a corporation formed under the laws of Israel, and the Purchasers (as
defined in the Purchase Agreement), dated as of the Closing Date (as defined in
the Purchase Agreement), acknowledges having read the representations in the
Purchase Agreement section entitled "Representations of the Purchasers," and
hereby represents that the statements contained therein are complete and
accurate with respect to the undersigned as a Purchaser. The undersigned further
hereby agrees to be bound by the terms and conditions of (i) the Purchase
Agreement as a "Purchaser" thereunder, and (ii) the Stockholders Agreement (as
defined in the Purchase Agreement) as a "Purchaser" thereunder and authorizes
this signature page to be attached to the Purchase Agreement, the Stockholders
Agreement, or counterparts thereof.

      Executed, in counterpart, as of the date set forth below.

                                        PURCHASER:

                                        By: /s/ Illegible
                                            ------------------------------------
                                            Prof. Zvi Naor, by YVC Yozma as
                                            proxy holder

                                        By: ____________________________________
                                        Title: _________________________________
                                        Date: __________________________________
                                        Contact Person: ________________________
                                        Telephone No: __________________________
                                        Telecopy No: ___________________________
                                        Email Address: _________________________

<PAGE>

                                    EXHIBIT B

                            FINANCING SIGNATURE PAGE

      By execution and delivery of this signature page, the undersigned hereby
agrees to become a Purchaser, as defined in that certain Convertible Preferred
Stock Agreement of Sale (the "Purchase Agreement") by and among Physiome
Sciences, Inc., a Delaware corporation (the "Company"), Predix Pharmaceuticals,
Ltd., a corporation formed under the laws of Israel, and the Purchasers (as
defined in the Purchase Agreement), dated as of the Closing Date (as defined in
the Purchase Agreement), acknowledges having read the representations in the
Purchase Agreement section entitled "Representations of the Purchasers," and
hereby represents that the statements contained therein are complete and
accurate with respect to the undersigned as a Purchaser. The undersigned further
hereby agrees to be bound by the terms and conditions of (i) the Purchase
Agreement as a "Purchaser" thereunder, and (ii) the Stockholders Agreement (as
defined in the Purchase Agreement) as a "Purchaser" thereunder and authorizes
this signature page to be attached to the Purchase Agreement, the Stockholders
Agreement, or counterparts thereof.

      Executed, in counterpart, as of the date set forth below.

                                        PURCHASER:

                                        By: /s/ Illegible
                                            ------------------------------------
                                            RAMOT at Tel. Aviv University Ltd.,
                                            by YVC Yozma as proxy holder

                                        By: ____________________________________
                                        Title: _________________________________
                                        Date: __________________________________
                                        Contact Person: ________________________
                                        Telephone No: __________________________
                                        Telecopy No: ___________________________
                                        Email Address: _________________________

<PAGE>

                                    EXHIBIT B

                            FINANCING SIGNATURE PAGE

      By execution and delivery of this signature page, the undersigned hereby
agrees to become a Purchaser, as defined in that certain Convertible Preferred
Stock Agreement of Sale (the "Purchase Agreement") by and among Physiome
Sciences, Inc., a Delaware corporation (the "Company"), Predix Pharmaceuticals,
Ltd., a corporation formed under the laws of Israel, and the Purchasers (as
defined in the Purchase Agreement), dated as of the Closing Date (as defined in
the Purchase Agreement), acknowledges having read the representations in the
Purchase Agreement section entitled "Representations of the Purchasers," and
hereby represents that the statements contained therein are complete and
accurate with respect to the undersigned as a Purchaser. The undersigned further
hereby agrees to be bound by the terms and conditions of (i) the Purchase
Agreement as a "Purchaser" thereunder, and (ii) the Stockholders Agreement (as
defined in the Purchase Agreement) as a "Purchaser" thereunder and authorizes
this signature page to be attached to the Purchase Agreement, the Stockholders
Agreement, or counterparts thereof.

      Executed, in counterpart, as of the date set forth below.

                                        PURCHASER:

                                        By: /s/ FREDERICK FRANK
                                            ------------------------------------
                                            Frederick Frank

                                        By: ____________________________________
                                        Title: _________________________________
                                        Date: __________________________________
                                        Contact Person: ________________________
                                        Telephone No: __________________________
                                        Telecopy No: ___________________________
                                        Email Address: _________________________

<PAGE>

                                    EXHIBIT C

                AMENDED AND RESTATED CERTIFICATE OF INCORPORATION
                           OF PHYSIOME SCIENCES, INC.
<PAGE>

                AMENDED AND RESTATED CERTIFICATE OF INCORPORATION
                                       OF
                             PHYSIOME SCIENCES, INC.

      Physiome Sciences, Inc., a corporation organized and existing under the
laws of the State of Delaware (hereinafter referred to as the "Corporation"),
hereby certifies as follows:

      1. The name of the Corporation is Physiome Sciences, Inc. The Corporation
was originally incorporated under the game Takhus Pharmaceuticals, Inc. and
filed its original certificate of incorporation with the Secretary of State of
the State of Delaware on November 2, 1994.

      2. This Amended and Restated Certificate of Incorporation amends and
restates in its entirety the Corporation's certificate of incorporation, as
amended and restated from time to time, to amend, among other things, the
following to: (i) change its name to Predix Pharmaceuticals Holdings, Inc.; (ii)
provide for a one-for-17.971067 reverse stock split of the Corporation's
Existing Common Stock; (iii) create a new class of Class A Common Stock; (iv)
reclassify and convert the outstanding shares of the Corporation's Series A
Convertible Preferred Stock, Series B Convertible Preferred Stock and Series C
Convertible Preferred Stock into shares of a newly created class of Series A
Convertible Preferred Stock and delete all references to such prior preferred
classes; (v) reclassify and convert the outstanding shares of the Corporation's
Series D Convertible Preferred Stock into shares of a newly created class of
Series B Convertible Preferred Stock and delete all references to such prior
preferred class; and (vi) designate the newly created Series A Convertible
Preferred Stock and Series B Convertible Preferred Stock as set forth below.

      3. This Amended end Restated Certificate of Incorporation was duly adopted
in accordance with the provisions of Sections 228, 242 and 245 of the General
Corporation Law of the State of Delaware, the requisite written consent of the
holders of each class of stock entitled to vote thereon has been voted in favor
of this Amended and Restated Certificate of Incorporation and written notice has
been given as provided by Section 228 of the General Corporation Law of the
State of Delaware. This Amended and Restated Certificate of Incorporation
(referred to hereinafter as the "Certificate of Incorporation") restates,
integrates and further amends the provisions of the Corporation's certificate of
incorporation, as amended to date (including all certificates of designation),
as follows:

      FIRST. The name of the corporation is Predix Pharmaceuticals Holdings,
Inc. (the "Corporation").

      SECOND. The address of the Corporation's registered office in the State of
Delaware is Corporation Service Company, 2711 Centerville Road, Suite 400, in
the City of Wilmington, County of New Castle, Delaware, 19808. The name of its
registered agent at such address is the Corporation Service Company.

<PAGE>

      THIRD. The nature of the business or purposes to be conducted or promoted
by the Corporation is as follows:

      To engage in any lawful act or activity for which corporations may be
organized under the General Corporation Law of the state of Delaware (the
"DGCL").

      FOURTH. Upon this Amended and Restated Certificate of Incorporation
becoming effective pursuant to the DGCL (the "Effective Time"), a
one-for-17.971067 reverse stock split of the Corporation's Common Stock, $.01
par value per share (the "Existing Common Stock"), shall become effective,
pursuant to which each share of the Corporation's Existing Common Stock issued
and outstanding and held of record by each stockholder of the Corporation
(including treasury shares) immediately prior to the Effective Time shall be
reclassified and converted into 0.055645 fully paid and nonassessable shares of
the Corporation's Common Stock, $.01 par value per share (the "New Common
Stock"), automatically and without any action by the holder thereof upon the
Effective Time. Any stock certificate that, immediately prior to the Effective
Time, represented shares of the Corporation's Existing Common Stock shall
automatically and without the necessity of presenting the same for exchange,
represent 0.055645 shares of the Corporation's New Common Stock from and after
the Effective Time for each share of Existing Common Stock outstanding
immediately prior to the Effective Time and represented by such certificate. No
fractional shares of New Common Stock shall be issued as a result of such
reclassification and conversion. In lieu of any fractional shares to which the
stockholder would otherwise be entitled, the Corporation shall pay cash equal to
such fraction multiplied by the then fair market value of the Corporation's New
Common Stock as determined by the Board of Directors of &a Corporation.

      Upon the Effective Time, each share of the Corporation's Series A
Convertible Preferred Stock, $.01 par value per share (the "Existing Series A
Preferred Stock"), issued and outstanding or held in treasury of the Corporation
is hereby reclassified and converted (irrespective of any accrued dividends or
adjustments to the conversion price of the Existing Series A Preferred Stock)
into 0.022104 fully paid and nonassessable shares of the Corporation's New
Series A Preferred Stock, as defined in Article FIFTH, automatically and without
any action by the holder thereof upon the Effective Time and all accrued and
unpaid dividends thereon, if any, shall be cancelled. Any stock certificate
that, immediately prior to the Effective Time, represented shares of the
Corporation's Existing Series A Preferred Stock shall, automatically and without
the necessity of presenting the same for exchange, represent 0.022104 shares of
the Corporation's New Series A Preferred Stock from and after the Effective Time
for each share of Existing Series A Preferred Stock outstanding immediately
prior to the Effective Time and represented by such certificate. No fractional
shares of New Series A Preferred Stock shall be issued as a result of such
reclassification and conversion. In lieu of any fractional shares to which the
stockholder would otherwise be entitled, the Corporation shall pay cash equal to
such fraction multiplied by the then fair market value of the Corporation's New
Series A Preferred Stock as determined by the Board of Directors of the
Corporation.

      Upon the Effective Time, each share of the Corporation's Series B
Convertible Preferred Stock, $.01 par value per share (the "Existing Series B
Preferred Stock"), issued and outstanding or held in treasury of the Corporation
is hereby reclassified and converted (irrespective of any accrued dividends or
adjustments to the conversion price of the Existing Series B Preferred

<PAGE>

      Stock) into 0.035661 fully paid and nonassessable shares of the
Corporation's New Series A Preferred Stock automatically and without any action
by the holder thereof upon the Effective Time and all accrued and unpaid
dividends thereon, if any, shall be cancelled. Any stock certificate that,
immediately prior to the Effective Time, represented shares of the Corporation's
Existing Series B Preferred Stock shall, automatically and without the necessity
of presenting the same for exchange, represent 0.035661 shares of the
Corporation's New Series A Preferred Stock from and after the Effective Time for
each share of Existing Series B Preferred Stock outstanding immediately prior to
the Effective Time and represented by such certificate. No fractional shares of
New Series A Preferred Stock shall be issued as a result of such
reclassification and conversion. In lieu of any fractional shares to which the
stockholder would otherwise be entitled, the Corporation shall pay cash equal to
such fraction multiplied by the then fair market value of the Corporation's New
Series A Preferred Stock as determined by the Board of Directors of the
Corporation

      Upon the Effective Time, each share of the Corporation's Series C
Convertible Preferred Stock, $.01 par value per share (the "Series C Preferred
Stock"), issued and outstanding or held in treasury of the Corporation is hereby
reclassified and converted (irrespective of any accrued dividends or adjustments
to the conversion price of the Series C Preferred Stock) into 0.084149 fully
paid and nonassessable shares of the Corporation's New Series A Preferred Stock
automatically and without any action by the holder thereof upon the Effective
Time and all accrued and unpaid dividends thereon, if any, shall be cancelled.
Any stock certificate that, immediately prior to the Effective Time, represented
shares of the Corporation's Series C Preferred Stock stall, automatically and
without the necessity of presenting the same for exchange, represent 0.084149
shares of the Corporation's New Series A Preferred Stock from and after the
Effective Time for each share of Series C Preferred Stock outstanding
immediately prior to the Effective Time and represented by such certificate. No
fractional shares of New Series A Preferred Stock shall be issued as a result of
such reclassification and conversion. In lieu of any fractional shares to which
the stockholder would otherwise be entitled, the Corporation shall pay cash
equal to such fraction multiplied by the then fair market value of the
Corporation's New Series A Preferred Stock as determined by the Board of
Directors of the Corporation.

      Upon the Effective Time, each share of the Corporation's Series D
Convertible Preferred Stock, $.01 par value per share (the "Series D Preferred
Stock"), issued and outstanding or held in treasury of the Corporation is hereby
reclassified and converted (irrespective of any accrued dividends or adjustments
to the conversion price of the Series D Preferred Stock) into 0.123774 fully
paid and nonassessable shares of the Corporation's New Series B Preferred Stock,
as defined in Article FIFTH, automatically and without any action by the holder
thereof upon the Effective Time and all accrued and unpaid dividends thereon, if
any, shall be cancelled. Any stock certificate that, immediately prior to the
Effective Time, represented shares of the Corporation's Series D Preferred Stock
shall, automatically and without the necessity of presenting the same for
exchange, represent 0.123774 shares of the Corporation's New Series B Preferred
Stock from and after the Effective Time for each share of Series D Preferred
Stock outstanding immediately prior to the Effective Time and represented by
such certificate. No fractional shares of New Series B Preferred Stock shall be
issued as a result of such reclassification and conversion. In lieu of any
fractional shares to which the stockholder would otherwise be entitled, the
Corporation shall pay cash equal to such fraction multiplied by the then

<PAGE>

      fair market value of the Corporation's New Series B Preferred Stock as
determined by the Board of Directors of the Corporation.

      FIFTH. The total number of shares of all classes of stock which the
Corporation shall have authority to issue is forty eight million (48,000,000)
shares, consisting of: (i) forty million (40,000,000) shares of New Common
Stock; (ii) four million four hundred thousand (4,400,000) shares of Class A
Common Stock, $0.01 par value per share (the "Class A Common Stock"); (iii) one
million one hundred thousand (1,100,000) shares of Series A Convertible
Preferred Stock, $0.01 par value per share (the "New Series A Preferred Stock"
or the "Series A Preferred Stock"); and (iv) two million five hundred thousand
(2,500,000) shares of Series B Convertible Preferred Stock, $0.01 per value per
share (the "New Series B Preferred Stock" or the "Series B Preferred Stock").
The Series A Preferred. Stock and the Series B Preferred Stock are sometimes
referred to herein as the "Designated Preferred Stock". The New Common Stock and
the Class A Common Stock are sometimes referred to herein as the "Common Stock".

      The following is a statement of the designations and the powers,
privileges and rights, and the qualifications, limitations or restrictions
thereof in respect of each class of capital stock of the Corporation.

A.    COMMON STOCK

      1. Dividends. The holders of Common Stock, subject to the preferential
rights of the holders of any of the then outstanding Series A Preferred Stock,
Series B Preferred Stock and any other class or series of shares ranking (as to
dividends) senior to the Common Stock, shall be entitled to receive dividends
and the Corporation shall pay dividends thereon, as, if and when declared by the
Board of Directors of the Corporation out of funds legally available for the
payment of dividends, in such amount and in such form as the Board of Directors
may from time to time determine. All dividends which the Board of Directors may
declare on the New Common Stock shall be declared and paid in equal amounts per
share on all New Common Stock at the time outstanding, All dividends which the
Board of Directors may declare on the Class A Common Stock shall be declared and
paid in equal amounts per share on all Class A Common Stock at the time
outstanding.

      2. Liquidation. In the event of the liquidation, dissolution or winding up
of the Corporation, either voluntary or involuntary, or other distribution of
assets of the Corporation among its stockholders for the purpose of winding up
its affairs, pursuant to applicable law, the holders of the Common Stock,
subject to the preferential rights of any of the holders of the then outstanding
Series A Preferred Stock, Series B Preferred Stock and any other class or series
of stock ranking on liquidation, dissolution or winding up senior to the Common
Stock, and except as may otherwise be provided pursuant to Section B.2 below,
shall be entitled to receive all the assets of the Corporation available for
distribution to its stockholders. Such distributions shall be paid in equal
amounts per share on all Common Stock at the time outstanding. Notwithstanding
the foregoing, the New Common Stock shall have such preferential rights over the
Class A Common Stock in the event of any liquidation, dissolution or winding up
of the Corporation or other distribution of Assets of the Corporation among its
stockholders for the purposes of winding up its affairs as set forth herein.

<PAGE>

      3. Voting. The holders of Common Stock shall be entitled to receive notice
of and to attend all meetings of the stockholders of the Corporation and shall
have one vote for each share of Common Stock held at all meetings of the
stockholders of the Corporation, except for meetings at which only holders of
another specified class or series of shares of the Corporation are entitled to
vote separately as a class or series.

B.    SERIES A CONVERTIBLE PREFERRED STOCK AND SERIES B CONVERTIBLE PREFERRED
      STOCK

      1.    Dividends.

            (a) The Corporation shall not declare, pay or set aside any
dividends (other than dividends payable in shares of New Common Stock) on Common
Stock unless the holders of the Series A Preferred Stock and Series B Preferred
Stock then outstanding shall first receive, or simultaneously receive, a
dividend on each outstanding share of Series A Preferred Stock and Series B
Preferred Stock equal to the product of (i) the per share dividend to be
declared, paid or set aside for the Common Stock multiplied by (ii) the number
of shares of New Common Stock into which each share of Series A Preferred Stock
or Series B Preferred Stock is then convertible.

            (b) In the event that there shall be declared but unpaid dividends
outstanding with respect to the Series A Preferred Stock or Series B Preferred
Stock immediately prior to, and in the event of, a conversion of any shares of
Series A Preferred Stock or Series B Preferred Stock as provided in Section 4
hereof, the Corporation shall, at the option of each holder of such shares, pay
in cash, out of funds legally available therefor, to each such holder the full
amount of any such dividends or, unless registration or qualification of such
New Common Stock would be required under applicable securities laws, allow such
dividends to be converted into New Common Stock in accordance with, and pursuant
to the terms specified in, Section 4 hereof.

      2. Liquidation, Dissolution or Winding Up; Certain Mergers, Consolidations
and Asset Sales

            (a) Liquidation. In the event of any liquidation, dissolution or
winding up of the Corporation, either voluntary or involuntary, or other
distribution of assets of the Corporation among its stockholders for the purpose
of winding up its affairs, pursuant to applicable law, all the assets of the
Corporation available for distribution among the stockholders shall be
distributed to them in the following order and preference:

                  (i) First, each holder of Series B Preferred Stock shall be
entitled to receive, prior and in preference to any distribution of any of the
assets of the Corporation to any other stockholders by reason of their ownership
thereof, an amount equal to the Series B Conversion Price (as defined in Section
4 below) (as adjusted to reflect stock splits, stock dividends,
recapitalizations and similar transactions) for each outstanding share of Series
B Preferred Stock held by such stockholder (the "Preferred B Preference"). If
upon the occurrence of such event, the assets and funds thus distributed among
the holders of the Series B Preferred Stock shall be insufficient to permit the
payment to such holders of the full Preferred B Preference, then the entire
assets and funds of the Corporation legally available for distribution

<PAGE>

                  shall be distributed ratably among the holders of the Series B
Preferred Stock in proportion to the amount of such stock owned by each such
holder.

                  (ii) Second, following payment of the Preferred B Preference,
each holder of Series A Preferred Stock shall be entitled to receive, prior and
in preference to any distribution of any of the assets of the Corporation to any
other stockholders by reason of their ownership thereof, an amount equal to the
Series A Conversion Price (as defined in Section 4 below) (as adjusted to
reflect stock splits, stock dividends, recapitalizations and similar
transactions) for each outstanding share of Series A Preferred Stock held by
such stockholder (the "Preferred A Preference"). If upon the occurrence of such
event, the assets and funds thus distributed among the holders of the Series A
Preferred Stock shall be insufficient to permit the payment to such holders of
the full Preferred A Preference, then the entire remaining assets and funds of
the Corporation legally available for distribution shall be distributed ratably
among the holders of the Series A Preferred Stock in proportion to the amount of
such stock owned by each such holder.

                  (iii) Third, following payment of the Preferred A Preference,
each holder of New Common Stock shall be entitled to receive, prior and in
preference to any distribution of any of the assets of the Corporation to any
other stockholders by reason of their ownership thereof, an amount equal to
$1.00 (as adjusted to reflect stock splits, stock dividends, recapitalizations
and similar transactions) for each outstanding share of New Common Stock held by
such stockholder (the "New Common Preference"). If upon the occurrence of such
event, the assets and funds thus distributed among the holders of the New Common
Stock shall be insufficient to permit the payment to such holders of the full
New Common Preference, then the entire remaining assets and funds of the
Corporation legally available for distribution shall be distributed ratably
among the holders of the New Common Stock in proportion to the amount of such
stock owned by each such holder.

                  (iv) Fourth, after payment of the Preferred B Preference,
Preferred A Preference and New Common Preference, the entire remaining assets
and funds of the Corporation legally available for distribution, if any, shall
be distributed pro rata among all holders of the Series B Preferred Stock,
Series A Preferred Stock and Common Stock (treating all holders of Series B
Preferred Stock and Series A Preferred Stock as holders of Common Stock on an
as-converted to New Common Stock basis).

            (b) Other Liquidation Events (Cash Consideration Only). In the event
of (i) a merger or consolidation of the Corporation with or into another entity
(except if such merger or consolidation does not result in the transfer of more
than 50% by voting power of the outstanding capital stock of the Corporation or
in which the holders of 50% or more by voting power of the outstanding capital
stock of the Corporation immediately prior to such transaction continue, by
virtue of their holdings of securities of the Corporation, to hold 50% or more
by voting power of the outstanding capital stock of the surviving corporation
immediately after the transaction); or (ii) the sale, in a single transaction or
series of related transactions, by the Corporation of all or substantially all
the assets of the Corporation (except where such sale is to a wholly-owned
subsidiary of the Corporation) (such events described in Section 2(b)(i) and
Section 2(b)(ii) referred to as "Deemed Liquidation Events"), pursuant to which
the consideration in connection with such Deemed Liquidation Events is paid
solely in cash, such consideration, less any

<PAGE>

            obligations of the Corporation not specifically assumed in writing
by the potential acquiror under the terms of the contemplated transaction, shall
be distributed among the Corporation's stockholders in the following order and
preference:

                  (A) First, each holder of Series B Preferred Stock shall be
entitled to receive, prior and in preference to any distribution of any of the
funds of the Corporation to any other stockholders by reason of their ownership
thereof, an amount equal to the Preferred B Preference for each outstanding
share of Series B Preferred Stock held by such stockholder. If upon the
occurrence of such event, the funds thus distributed among the holders of the
Series B Preferred Stock shall be insufficient to permit the payment to such
holders of the full Preferred B Preference, then such consideration less any
required obligations of the Corporation shall be distributed ratably among the
holders of the Series B Preferred Stock in proportion to the amount of such
stock owned by each such holder.

                  (B) Second, following payment of the Preferred B Preference
pursuant to Section 2(b)(A), the holders of Series A Preferred Stock and New
Common Stock shall be entitled to receive, prior and in preference to any
distribution of any of the funds of the Corporation to any other stockholders by
reason of their ownership thereof, an amount equal to the New Common Preference
(treating all holders of Series A Preferred Stock on an as-converted to New
Common Stock basis). If upon the occurrence of such event, the funds thus
distributed among the holders of the Series A Preferred Stock (on an
as-converted to New Common Stock basis) and New Common Stock shall be
insufficient to permit the full payment of the New Common Preference to such
holders, then such consideration less any required obligations of the
Corporation shall be distributed ratably among the holders of the Series A
Preferred Stock and New Common Stock in proportion to the amount of such stock
owned by each holder, on an as-converted to New Common Stock basis.

                  (C) Third, after the payments set forth in Section 2(b)(A) and
Section 2(b)(B) above, the entire remaining consideration, if any, shall be
distributed pro rata among all holders of the Series B Preferred Stock, Series A
Preferred Stock and Common Stock (treating all holders of Series B Preferred
Stock and Series A Preferred Stock as holders of Common Stock on an as-converted
to New Common Stock basis).

            (c) Other Liquidation Events (Including Non-Cash Consideration). In
the event of a Deemed Liquidation Event pursuant to which the consideration to
the Corporation in connection with such Deemed Liquidation Event is paid (i)
solely in property, rights and/or securities of the acquiring person, firm or
other entity or (ii) in a combination of property, rights and/or securities of
the acquiring person, firm or other entity and cash, such consideration, less
any obligations of the Corporation not specifically assumed in writing by the
potential acquiror under the terms of the contemplated transaction, shall be
distributed among the Corporation's stockholders in the following order and
preference:

                  (A) First, all cash consideration shall be distributed in
accordance with the procedure set forth in Sections 2(b)(A)-(C) above.

                  (B) Second, the value of such property, rights and/or
securities shall be determined in good faith by the Board of Directors of the
Corporations and shall be

<PAGE>

distributed pro rata among all holders of the Series B Preferred Stock, Series A
Preferred Stock and Common Stock (treating all holders of Series B Preferred
Stock and Series A Preferred Stock as holders of Common Stock on as as-converted
to New Common Stock basis).

      3.    Voting

            (a) On any matter presented to the stockholders of the Corporation
for their action or consideration at any meeting of stockholders of the
Corporation (or by written action of stockholders in lieu of meeting), each
holder of outstanding Designated Preferred Stock shall be entitled to the number
of votes equal to the number of whole shares of New Common Stock into which the
Designated Preferred Stock held by such holder is convertible as of the record
date for determining stockholders entitled to vote on such matter. Except as
provided by law or otherwise provided herein, the holders of Designated
Preferred Stock shall vote together with the holders of Common Stock, and with
the holders of any other class or series of capital stock the terms of which so
provide, as a single class.

            (b) Until the consummation of an Initial Public Offering (as defined
in Section 5), the Corporation shall not, without the affirmative vote of the
holders of at least 60% of the issued and outstanding shares of Series B
Preferred Stock take any action which alters or modifies the rights, preferences
or privileges of the Series B Preferred Stock set forth in Section 2 hereof.

            (c) Until the consummation of an Initial Public Offering, the
Corporation shall not, without the affirmative vote of the holders of at least
60% of the issued and outstanding shares of capital stock of the Corporation,
voting as a single class on an as-converted to Common Stock basis, effect a
Deemed Liquidation Event.

      4.    Optional Conversion.

The holders of the Designated Preferred Stock shall have conversion rights as
follows (the "Conversion Rights"):

            (a) Right to Convert. Each share of Series A Preferred Stock and
Series B Preferred Stock shall be convertible, at the option of the holder
thereof, at any time and from time to time, and without the payment of
additional consideration by the holder thereof, into such number of fully paid
and nonassessable shares of New Common Stock as is determined by dividing
$100.00 by the Series A Conversion Price (as defined below) or Series B
Conversion Price (as defined below), as applicable, in effect at the time of
conversion. The "Series A Conversion Price" and "Series B Conversion Price"
shall initially be $10.00 per share. Such initial Series A Conversion Price and
Series B Conversion Price, and the rate at which Series A Preferred Stock and
Series B Preferred Stock may be converted into New Common Stock, shall be
subject to adjustment as provided below.

In the event of a liquidation, dissolution or winding up of the Corporation, the
Conversion Rights shall terminate at the close of business on the last full day
preceding the date fixed for the payment of any such amounts distributable on
such event to the holders of Series A Preferred Stock and Series B Preferred
Stock. In the event of such a liquidation, dissolution or winding up, the
Corporation shall provide to each holder of Series A Preferred Stock and Series
B Preferred

<PAGE>

Stock notice of such liquidation, dissolution or winding up, which notice shall
(i) be sent at least 15 days prior to the termination of the Conversion Rights
and (ii) state the amount per share of Series A Preferred Stock and Series B
Preferred Stock that will be paid or distributed on such liquidation,
dissolution or winding up, as the case may be.

            (b) Fractional Shares. No fractional shares of New Common Stock
shall be issued upon conversion of the Series A Preferred Stock or Series B
Preferred Stock. In lieu of any fractional shares to which the holder would
otherwise be entitled, the Corporation shall pay cash equal to such fraction
multiplied by the then fair market of the New Common Stock as determined by the
Board of Directors of the Corporation.

            (c) Mechanics of Conversion.

                  (i) In order for a holder of Designated Preferred Stock to
convert such Designated Preferred Stock into New Common Stock, such holder shall
surrender the certificate or certificates for such Designated Preferred Stock,
at the office of the transfer agent for the Designated Preferred Stock (or at
the principal office of the Corporation if the Corporation serves as its own
transfer agent), together with written notice that such holder elects to convert
all or any number of shares of the Designated Preferred Stock represented by
such certificate or certificates. Such notice shall state such holder's name in
which such holder wishes the certificate or certificates for New Common Stock to
be issued. If required by the Corporation, certificates surrendered for
conversion shall be endorsed or accompanied by a written instrument or
instruments of transfer, in form satisfactory to the Corporation, duly executed
by the registered holder or his or its attorney duly authorized in writing. The
date of receipt of such certificates and notice by the transfer agent (or by the
Corporation if the Corporation serves as its own transfer agent) shall be the
conversion date ("Conversion Date"), and the New Common Stock issuable upon
conversion of the shares represented by such certificate shall be deemed to be
outstanding of record as of such date. The Corporation shall, as soon as
practicable after the Conversion Date, issue and deliver at such office to such
holder of Designated Preferred Stock, a certificate or certificates for the
number of shares of New Common Stock to which such holder shall be entitled,
together with cash in lieu of any fraction of a share.

                  (ii) The Corporation shall at all times when Designated
Preferred Stock shall be outstanding, reserve and keep available out of its
authorized but unissued capital stock, for the purpose of effecting the
conversion of the Designated Preferred Stock, such number of shares of its duly
authorized New Common Stock as shall from time to time be sufficient to effect
the conversion of all outstanding shares of Designated Preferred Stock.

                  (iii) Upon any such conversion, no adjustment to the Series A
Conversion Price or Series B Conversion Price shall be made for any declared but
unpaid dividends on the Designated Preferred Stock surrendered for conversion or
on the New Common Stock delivered upon conversion.

                  (iv) All Designated Preferred Stock which shall have been
surrendered for conversion as herein provided shall no longer be deemed to be
outstanding and all rights with respect to such shares, including the rights, if
any, to receive notices and to vote, shall immediately cease and terminate on
the Conversion Date, except only the right of the holders

<PAGE>

                  thereof to receive New Common Stock in exchange therefor and
payment of any dividends declared but unpaid thereon. Any Designated Preferred
Stock so converted shall be retired and cancelled and shall not be reissued.

                  (v) The Corporation shall pay any and all issue and other
similar taxes that may be payable in respect of any issuance or delivery of New
Common Stock upon conversion of Designated Preferred Stock pursuant to this
Section 4. The Corporation shall not, however, be required to pay any tax which
may be payable in respect of any transfer involved in the issuance and delivery
of New Common Stock in a name other than that in which the Designated Preferred
Stock so converted were registered, and no such issuance or delivery shall be
made unless and until the person or entity requesting such issuance has paid to
the Corporation the amount of any such tax or has established, to the
satisfaction of the Corporation, that such tax bas been paid.

            (d) Adjustment for Stock Splits and Combinations. If the Corporation
shall at any time or from time to time after the date the Corporation first
issued its Designated Preferred Stock (the "Original Issue Date") effect a
subdivision of the outstanding New Common Stock or combine the outstanding
Designated Preferred Stock, the Series A Conversion Price or Series B Conversion
Price, as applicable, then in effect immediately before that subdivision or
combination shall be proportionately decreased. If the Corporation shall at any
time or from time to time after the Original Issue Date combine the outstanding
New Common Stock or effect a subdivision of the outstanding Series A Preferred
Stock, the Series A Conversion Price or Series B Conversion Price, as
applicable, then in effect immediately before the combination or subdivision
shall be proportionately increased. Any adjustment under this paragraph shall
become effective at the close of business on the date the subdivision or
combination becomes effective.

            (e) Adjustment for Certain Dividends and Distributions. In the event
the Corporation at any time, or from time to time after the Original Issue Date
shall make or issue, or fix a record date for the determination of holders of
New Common Stock entitled to receive, a dividend or other distribution payable
is additional New Common Stock, then and in each such event the Series A
Conversion Price or Series B Conversion Price, as applicable, then in effect
immediately before such event shall be decreased as of the time of such issuance
or, in the event such a record date shall have been fixed, as of the close of
business on such record date, by multiplying the Series A Conversion Price or
Series B Conversion Price, as applicable, then in effect by a fraction:

                  (i) the numerator of which shall be the total number of shares
of New Common Stock issued and outstanding immediately prior to the time of such
issuance or the close of business on such record date, and

                  (ii) the denominator of which shall be the total number of
shares of New Common Stock issued and outstanding immediately prior to the time
of such issuance or the close of business on such record date plus the number of
shares of New Common Stock issuable in payment of such dividend or distribution;

<PAGE>

provided, however, that if such record date shall have been fixed and such
dividend is not fully paid or if such distribution is not fully made on the date
fixed therefor, the Series A Conversion Price or Series B Conversion Price, as
applicable, shall be recomputed accordingly as of the close of business on such
record date and thereafter the Series A Conversion Price or Series B Conversion
Price, as applicable, shall be adjusted pursuant to this paragraph as of the
time of actual payment of such dividends or distributions; and provided,
further, however, that no such adjustment shall be made if the holders of
Designated Preferred Stock simultaneously receive (i) a dividend or other
distribution of shares of New Common Stock in a number equal to the number of
shares of New Common Stock as they would have received if all outstanding shares
of Designated Preferred Stock had been converted into New Common Stock on the
date of such event or (ii) a dividend or other distribution of Designated
Preferred Stock which is convertible, as of the date of such event, into such
number of shares of New Common Stock as is equal to the number of additional
shares of New Common Stock being issued with respect to each share of New Common
Stock in such dividend or distribution.

            (f) Adjustments for Other Dividends and Distributions. In the event
the Corporation at any time or from time to time after the Original Issue Date
shall make or issue, or fix a record date for the determination of holders of
New Common Stock entitled to receive, a dividend or other distribution payable
in securities of the Corporation (other than New Common Stock) or in cash or
other property, then and in each such event the holders of Designated Preferred
Stock shall receive, simultaneously with the distribution to the holders of
Common Stock, a dividend or other distribution of such securities, cash or other
property in an amount equal to the amount of such securities, cash or other
property as they would have received if all outstanding shares of Designated
Preferred Stock had been converted into Common Stock on the date of such event.

            (g) Adjustment for Merger or Reorganization, etc. Subject to the
provisions of Section 2, if there shall occur any reorganization,
recapitalization, reclassification, consolidation, plan of merger involving the
Corporation in which the New Common Stock (but not the Designated Preferred
Stock) is converted into or exchanged for securities, cash or other property
(other than a transaction covered by paragraphs (d), (e) or (f) of this Section
4), then, following any such reorganization, recapitalization, reclassification,
consolidation or plan of merger, each share of Designated Preferred Stock shall
be convertible into the kind and amount of securities, cash or other property
which a holder of the number of shares of New Common Stock of the Corporation
issuable upon conversion of one share of Designated Preferred Stock immediately
prior to such reorganization, recapitalization, reclassification, consolidation,
plan of merger would have been entitled to receive pursuant to such transaction;
and, in such case, appropriate adjustment (as determined in good faith by the
Board of Directors of the Corporation) shall be made in the application of the
provisions in this Section 4 with respect to the rights and interests thereafter
of the holders of the Designated Preferred Stock, to the end that the provisions
set forth in this Section 4 (including provisions with respect to changes in and
other adjustments of the Series A Conversion Price or Series B Conversion Price
shall thereafter be applicable, as nearly as reasonably may be, in relation to
my securities or other property thereafter deliverable upon the conversion of
the Designated Preferred Stock.

            (h) No Impairment. The Corporation will not, by amendment of its
Certificate of Incorporation or through any reorganization, transfer of assets,
consolidation,

<PAGE>

            merger, dissolution, issue or sale of securities or any other
voluntary action, avoid or seek to avoid the observance or performance of any of
the terms to be observed or performed hereunder by the Corporation, but will at
all times in good faith assist in the carrying out of all the provisions of this
Section 4 and in the taking of all such action as may be necessary or
appropriate in order to protect the Conversion Rights of the holders of the
Designated Preferred Stock against impairment.

                  (i) Certificate as to Adjustments. Upon the occurrence of each
adjustment or readjustment of the Series A Conversion Price or Series B
Conversion Price pursuant to this Section 4, the Corporation at its expense
shall, as promptly as reasonably practicable but in any event not later than 15
days thereafter, compute such adjustment or readjustment in accordance with the
terms hereof and furnish to each holder of Designated Preferred Stock a
certificate setting forth such adjustment or readjustment (including the kind
and amount of securities, cash or other property into which the Designated
Preferred Stock is convertible) and showing in detail the facts upon which such
adjustment or readjustment is based. The Corporation shall, as promptly as
reasonably practicable after the written request at any time of any holder of
Designated Preferred Stock (but in any event not later than 15 days thereafter),
furnish or cause to be furnished to such holder a certificate setting forth (i)
the Series A Conversion Price or Series B Conversion Price, as applicable, then
in effect, and (ii) the number of shares of New Common Stock and the amount, if
any, of other securities, cash or property which then would be received upon the
conversion of Designated Preferred Stock.

            (j) Notice of Record Date. In the event:

                  (i) the Corporation shall take a record of the holders of its
Common Stock (or other shares or securities at the time issuable upon conversion
of the Designated Preferred Stock) for the purpose of entitling or enabling them
to receive any dividend or other distribution, or to receive any right to
subscribe for or purchase any shares of stock of any class or any other
securities, or to receive any other right; or

                  (ii) of any capital reorganization of the Corporation, any
reclassification of the Common Stock of the Corporation, any consolidation, plan
of merger of the Corporation with or into another entity (other than a
consolidation, plan of merger in which the Corporation is the surviving entity
and the Common Stock is not converted into or exchanged for any other securities
or property, or any transfer of all or substantially all of the assets of the
Corporation; or

                  (iii) of the voluntary or involuntary dissolution, liquidation
or winding up of the Corporation or other distribution of assets of the
Corporation among its stockholders for the purpose of winding up its affairs,

then, and in each such case, the Corporation will send or cause to be sent to
the holders of the Designated Preferred Stock a notice specifying, as the case
may be, (i) the record date for such dividend, distribution or right, and the
amount and character of such dividend, distribution or right, or (ii) the
effective date on which such reorganization, reclassification, consolidation,
plan of merger, transfer, dissolution, liquidation or winding-up is to take
place, and the time, if any is to be fixed, as of which the holders of record of
Common Stock (or such other stock or securities

<PAGE>

at the time issuable upon the conversion of the Designated Preferred Stock)
shall be entitled to exchange their Common Stock (or such other shares or
securities) for securities or other property, including cash, deliverable upon
such reorganization, reclassification, consolidation, plan of merger, transfer,
dissolution, liquidation or winding up. Such notice shall be sent at least 10
days prior to the record date or effective date for the event specified in such
notice.

      5.    Mandatory Conversion.

            (a) Upon the earlier of (A) the closing of the sale of New Common
Stock to the public in a firm commitment underwritten public offering pursuant
to an effective registration statement under the Securities Act of 1933, as
amended, resulting in gross proceeds to the Corporation of at least $25 million
(prior to the deduction of underwriters' commissions, discounts and expenses)
and at a pre-money valuation of the Corporation of no less than $100 million (an
"Initial Public Offering"), or (B) a date agreed to in writing by the holders of
at least sixty percent (60%) of the voting power of the then outstanding
Designated Preferred Stock (each, a "Mandatory Conversion Date"), (i) all
outstanding shares of Designated Preferred Stock shall automatically be
converted into New Common Stock, at the then effective conversion rate and (ii)
such shares may not be reissued by the Corporation as Designated Preferred
Stock.

            (b) All holders of record of Designated Preferred Stock shall be
given written notice of the Mandatory Conversion Date and the place designated
for mandatory conversion of all such Designated Preferred Stock pursuant to this
Section 5. Such notice need not be given in advance of the occurrence of the
Mandatory Conversion Date. Such notice shall be sent by first class or
registered mail, postage prepaid, or given by electronic communication, in
compliance with the provisions of the Corporation's governing corporate statute,
to each record holder of Designated Preferred Stock. Upon receipt of such
notice, each holder of Designated Preferred Stock shall surrender his, her or
its certificate or certificates for all such shares to the Corporation at the
place designated in such notice, and shall thereafter receive certificates for
the number of shares of New Common Stock to which such holder is entitled
pursuant to this Section 5. On the Mandatory Conversion Date, all outstanding
shares of Designated Preferred Stock shall be deemed to have been converted into
New Common Stock, which shall be deemed to be outstanding of record, and all
rights with respect to the Designated Preferred Stock so converted, including
the rights, if any, to receive notices and vote (other than as a holder of New
Common Stock) will terminate, except only the rights of the holders thereof,
upon surrender of their certificate or certificates therefor, to receive
certificates for the number of shares of New Common Stock into which such shares
of Designated Preferred Stock have been converted, and payment of any declared
but unpaid dividends thereon. If so required by the Corporation, certificates
surrendered for conversion shall be endorsed or accompanied by written
instrument or instruments of transfer, in form satisfactory to the Corporations,
duly executed by the registered holder or by his or its attorney duly authorized
in writing. As soon as practicable after the Mandatory Conversion Date and the
surrender of the certificate or certificates for Designated Preferred Stock, the
Corporation shall cause to be issued and delivered to such holder, or on his or
its written order, a certificate or certificates for the number of full shares
of New Common Stock issuable on such conversion in accordance with the
provisions hereof and cash as provided in Subsection 4(b) in respect of, any
fraction of a share of New Common Stock otherwise issuable upon such conversion.

<PAGE>

            (c) All certificates evidencing Designated Preferred Stock which are
required to be surrendered for conversion in accordance with the provisions
hereof shall, from and after the Mandatory Conversion Date, be deemed to have
been retired and cancelled and the Designated Preferred Stock represented
thereby converted into New Common Stock for all purposes, notwithstanding the
failure of the holder or holders thereof to surrender such certificates on or
prior to such date. Such converted Designated Preferred Stock may not be
reissued, and the Corporation may thereafter take such appropriate action
(without the need for stockholder action) as may be necessary to reduce the
authorized number of shares of Designated Preferred Stock accordingly.

      SIXTH. The Directors shall have power to adopt, amend, or repeal the
By-Laws of the Corporation.

      SEVENTH. Election of Directors need not be by written ballot unless the
By-Laws of the Corporation so provide.

      EIGHTH. Except as expressly provided herein, the Corporation shall
indemnify and hold harmless any director or officer of the Corporation or of any
wholly-owned subsidiary from and against any and all expenses and liabilities
that may be imposed upon or incurred in connection with, or as a result of, any
proceeding in which he or she may become involved, as a party or otherwise, by
reason of the fact that he or she is or was such a director or officer, whether
or not he or she continues to be such at the time such expenses and liabilities
shall have been imposed or incurred, to the fullest extent permitted by the DGCL
as it may be amended from time to time.

      The Corporation shall provide indemnification as follows:

      1. Actions, Suits and Proceedings Other than by or in the Right of the
Corporation. The Corporation shall indemnify each person who was or is a party
or threatened to be made a party to any threatened, pending or completed action,
suit or proceeding, whether civil, criminal, administrative or investigative
(other than an action by or in the right of the Corporation) by reason of the
fact that he or she is or was, or has agreed to become, a director or officer of
the Corporation or of a wholly owned subsidiary thereof, or is or was serving,
or has agreed to serve, at the request of the Corporation, as a director or
officer, partner, employee, agent or trustee of, or in a similar capacity with,
another corporation, partnership, joint venture, trust or other enterprise
(including any employee benefit plan) (all such persons being referred to
hereafter as an "Indemnitee"), or by reason of any action alleged to have been
taken or omitted in such capacity, against all expenses (including, attorneys'
fees), judgments, fines and amounts paid in settlement actually and reasonably
incurred by or on behalf of Indemnitee in connection with such action, suit or
proceeding and any appeal therefrom, if Indemnitee acted in good faith and in a
manner which Indemnitee reasonably believed to be in, or not opposed to, the
best interests of the Corporation, and, with respect to any criminal action or
proceeding, had no reasonable cause to believe his or her conduct was unlawful.
The termination of any action, suit or proceeding by judgment, order,
settlement, conviction or upon a plea of nolo contendere or its equivalent,
shall not, of itself, create a presumption that Indemnitee did not act in good
faith and in a manner which Indemnitee reasonably believed to be in, or not
opposed to, the best interests of the

<PAGE>

      Corporation, and, with respect to any criminal action or proceeding, had
reasonable cause to believe that his or her conduct was unlawful.

      2. Actions or Suits by or in the Right of the Corporation. The Corporation
shall indemnify any Indemnitee who was or is a party to or threatened to be made
a party to any threatened, pending or completed action or suit by or in the
right of the Corporation to procure a judgment in its favor by reason of the
fact that Indemnitee is or was, or has agreed to become, a director or officer
of the Corporation, or is or was serving, or has agreed to serve, at the request
of the Corporation, as a director or officer, partner, employee, agent or
trustee of, or in a similar capacity with, another corporation, partnership,
joint venture, trust or other enterprise (including any employee benefit plan),
or by reason of any action alleged to have been taken or omitted in such
capacity, against all expenses (including attorneys' fees) and, to the extent
permitted by law, amounts paid in settlement actually and reasonably incurred by
or on behalf of Indemnitee in connection with such action, suit or proceeding
and any appeal therefrom, if Indemnitee acted in good faith and in a manner
which Indemnitee reasonably believed to be in, or not opposed to, the best
interests of the Corporation, except that no indemnification shall be made under
this Section 2 in respect of any claim, issue or matter as to which Indemnitee
shall have been adjudged to be liable to the Corporation, unless, and only to
the extent, that the Court of Chancery of Delaware shall determine upon
application that, despite the adjudication of such liability but in view of all
the circumstances of the case, Indemnitee is fairly and reasonably entitled to
indemnity for such expenses (including attorneys' fees) which the Court of
Chancery of Delaware shall deem proper.

      3. Indemnification for Expenses of Successful Party. Notwithstanding any
other provisions of this Article EIGHTH, to the extent that an Indemnitee has
been successful, on the merits or otherwise, in defense of any action, suit or
proceeding referred to in Sections 1 and 2 of this Article EIGHTH, or in defense
of any claim, issue or matter therein, or on appeal from any such action, suit
or proceeding, Indemnitee shall be indemnified against all expenses (including
attorneys' fees) actually and reasonably incurred by or on behalf of Indemnitee
in connection therewith. Without limiting the foregoing, if any action, suit or
proceeding is disposed of, on the merits or otherwise (including a disposition
without prejudice), without (i) the disposition being adverse to Indemnitee,
(ii) an adjudication that Indemnitee was liable to the Corporation, (iii) a plea
of guilty or nolo contendere by Indemnitee, (iv) an adjudication that Indemnitee
did not act in good faith and in a manner he reasonably believed to be in or not
opposed to the best interests of the Corporation, or (v) with respect to any
criminal proceeding, an adjudication that Indemnitee had reasonable cause to
believe his conduct was unlawful, Indemnitee shall be considered for the
purposes hereof to have been wholly successful with respect thereto.

      4. Notification and Defense of Claim. As a condition precedent to an
Indemnitee's right to be indemnified, such indemnitee must notify the
Corporation in writing as soon as practicable of any action, suit, proceeding or
investigation involving such Indemnitee for which indemnity will or could be
sought. With respect to any action, suit, proceeding or investigation of which
the Corporation is so notified, the Corporation will be entitled to participate
therein at its own expense and/or to assume the defense thereof at its own
expense, with legal counsel reasonably acceptable to Indemnitee. After notice
from the Corporation to Indemnitee of its election so to assume such defense,
the Corporation shall not be liable to Indemnitee for any legal or other
expenses subsequently incurred by Indemnitee in connection with such action,
suit,

<PAGE>

      proceeding or investigation, other than as provided below in this Section
4. Indemnitee shall have the right to employ his or her own counsel in
connection with such action, suit, proceeding or investigation, but the fees and
expenses of such counsel incurred after notice from the Corporation of its
assumption of the defense thereof shall be at the expense of Indemnitee unless
(i) the employment of counsel by Indemnitee has been authorized by the
Corporation, (ii) counsel to Indemnitee shall have reasonably concluded that
there may be a conflict of interest or position on any significant issue between
the Corporation and Indemnitee in the conduct of the defense of such action,
suit, proceeding or investigation or (iii) the Corporation shall not in fact
have employed counsel to assume the defense of such action, suit, proceeding or
investigation, in each of which cases the fees and expenses of counsel for
Indemnitee shall be at the expense of the Corporation, except as otherwise
expressly provided by this Article EIGHTH. The Corporation shall not be
entitled, without the consent of Indemnitee, to assume the defense of any claim
brought by or in the right of the Corporation or as to which counsel for
Indemnitee shall have reasonably made the conclusion provided for in clause (ii)
above. The Corporation shall not be required to indemnify Indemnitee under this
Article EIGHTH for any amounts paid in settlement of any action, suit,
proceeding or investigation effected without its written consent. The
Corporation shall not settle any action, suit, proceeding or investigation in
any manner which would impose any penalty or limitation on Indemnitee without
Indemnitee's written consent. Neither the Corporation nor Indemnitee will
unreasonably withhold or delay its Consent to any proposed settlement.

      5. Advance of Expenses. Subject to the provisions of Section 6 of this
Article EIGHTH, in the event that the Corporation does not assume the defense
pursuant to Section 4 of this Article EIGHTH of any action, suit, proceeding or
investigation of which the Corporation receives notice under this Article, say
reasonable expenses (including attorneys' fees) incurred by or on behalf of an
Indemnitee in defending an action, suit, proceeding or investigation or any
appeal therefrom shall, to the fullest extent permitted by law, be paid by the
Corporation in advance of the final disposition of such matter, and only upon
receipt of and review by the Corporation of written estimates of such expenses;
provided, however, that the payment of such expenses incurred by or on behalf of
Indemnitee in advance of the final disposition of such matter shall be made only
upon receipt of (i) an undertaking by or on behalf of Indemnitee to repay all
amounts so advanced in the event that it shall ultimately be determined that
Indemnitee is not entitled to be indemnified by the Corporation as authorized in
this Article, and (ii) written invoices evidencing such expenses; and provided
further that no such advancement of expenses shall be made under this Article
EIGHTH if it is determined (in the manner described in Section 6) that (i)
Indemnitee did not act in good faith and in a manner he or she reasonably
believed to be in, or not opposed to, the best interests of the Corporation, or
(ii) with respect to any criminal action or proceeding, Indemnitee had
reasonable cause to believe his or her conduct was unlawful. Such undertaking
shall be accepted without reference to the financial ability of Indemnitee to
make such repayment.

      6. Procedure for Indemnification. In order to obtain indemnification or
advancement of expenses pursuant to Section 1, 2, 3 or 5 of this Article EIGHTH,
an Indemnitee shall submit to the Corporation a written request. Any such
advancement of expenses shall be made promptly, and in any event within 30 days
after receipt by the Corporation of the written request of Indemnitee, unless
the Corporation determines within such 30-day period that Indemnitee did not
meet the applicable standard of conduct set forth, in Section 1, 2 or 5 of this

<PAGE>

      Article EIGHTH, as the case may be. Any such indemnification, unless
ordered by a court, shall be made with respect to requests under Section 1 or 2
only as authorized in the specific case upon a determination by the Corporation
that the indemnification of Indemnitee is proper because Indemnitee has met the
applicable standard of conduct set forth in Section 1 or 2, as the case may be.
Such determination shall be made in each instance (a) by a majority vote of the
directors of the Corporation consisting of persons who are not at that time
parties to the action, suit or proceeding in question ("disinterested
directors'"), whether or not a quorum, (b) by a committee of disinterested
directors designated by majority vote of disinterested directors, whether or not
a quorum, (c) if there are no disinterested directors, or if the disinterested
directors so direct, by independent legal counsel (who may, to the extent
permitted by law, be regular legal counsel to the Corporation) in a written
opinion, or (d) by the stockholders of the Corporation.

      7. Remedies. The right to indemnification or advancement of expenses as
granted by this Article EIGHTH shall be enforceable by Indemnitee in any court
of competent jurisdiction. Neither the failure of the Corporation to have made a
determination prior to the commencement of such action that indemnification is
proper in the circumstances because Indemnitee has met the applicable standard
of conduct, nor an actual determination by the Corporation pursuant to Section 6
of this Article EIGHTH that Indemnitee has not met such applicable standard of
conduct, shall be a defense to the action or create a presumption that
Indemnitee has not met the applicable standard of conduct. Indemnitee's expenses
(including attorneys' fees) reasonably incurred in connection with successfully
establishing Indemnitee's right to indemnification, in whole or in part, in any
such proceeding shall also be indemnified by the Corporation.

      8. Limitations. Notwithstanding anything to the contrary in this Article
EIGHTH, except as set forth in Section 7 of this Article EIGHTH, the Corporation
shall not indemnify an Indemnitee pursuant to this Article EIGHTH in connection
with a proceeding (or part thereof) initiated by such Indemnitee unless the
initiation thereof was approved by the Board of Directors of the Corporation.
Notwithstanding anything to the contrary in this Article EIGHTH, the Corporation
shall not indemnify an Indemnitee to the extent such Indemnitee is reimbursed
from the proceeds of insurance, and in the event the Corporation makes any
indemnification payments to an Indemnitee and such Indemnitee is subsequently
reimbursed from the proceeds of insurance, Indemnitee shall promptly refund such
indemnification payments to the Corporation to the extent of such insurance
reimbursement.

      9. Subsequent Amendment. To the fullest extent permitted by law, no
amendment, termination or repeal of this Article EIGHTH or of the relevant
provisions of the DGCL or any other applicable laws shall affect or diminish in
any way the rights of any Indemnitee to indemnification under the provisions
hereof with respect to any action, suit, proceeding or investigation arising out
of or relating to any actions, transactions or facts occurring prior to the
final adoption of such amendment, termination or repeal.

      10. Other Rights. The indemnification and advancement of expenses provided
by this Article EIGHTH shall not be deemed exclusive of any other rights to
which an Indemnitee seeking indemnification or advancement of expenses may be
entitled under any law (common or statutory), agreement or vote of stockholders
or disinterested directors or otherwise, both as to

<PAGE>

      action in Indemnitee's official capacity and as to action in any other
capacity while holding a directorship or office for the Corporation, and shall
continue as to an Indemnitee who has ceased to be a director or officer, and
shall inure to the benefit of the estate, heirs, executors and administrators of
Indemnitee. Nothing contained in this Article EIGHTH shall be deemed to
prohibit, and the Corporation is specifically authorized to enter into,
agreements with officers and directors providing indemnification rights and
procedures different from those set forth in this Article EIGHTH. In addition,
the Corporation may, to the extent authorized from time to time by its Board of
Directors, grant indemnification rights to other employees or agents of the
Corporation or other persons serving the Corporation and such rights may be
equivalent to, or greater or less than, those set forth in this Article EIGHTH.

      11. Partial Indemnification. If an Indemnitee is entitled under any
provision of this Article EIGHTH to indemnification by the Corporation for some
or a portion of the expenses (including attorneys' fees), judgments, fines or
accounts paid in settlement actually and reasonably incurred by or on behalf of
Indemnitee in connection with any action, suit, proceeding or investigation and
any appeal therefrom but not, however, for the total amount thereof, the
Corporation shall nevertheless indemnify Indemnitee for the portion of such
expenses (including attorneys' fees), judgments, fines or amounts paid in
settlement to which Indemnitee is entitled.

      12. Insurance. The Corporation may purchase and maintain insurance, at its
expense, to protect itself and any director or officer of the Corporation or of
a wholly owned subsidiary or another corporation, partnership, joint venture,
trust or other enterprise (including any employee benefit plan) against any
expense, liability or loss incurred by him in any such capacity, or arising out
of his status as such, whether or not the Corporation would have the power to
indemnify such person against such expense, liability or loss under the DGCL.

      13. Savings Clause. If this Article EIGHTH or any portion hereof shall be
invalidated on any ground by any court of competent jurisdiction, then the
Corporation shall nevertheless indemnify each Indemnitee as to any expenses
(including attorneys' fees), judgments, fines and amounts paid in settlement in
connection with any action, suit, proceeding or investigation, whether civil,
criminal or administrative, including an action by or in the right of the
Corporation, to the fullest extent permitted by any applicable portion of this
Article EIGHTH that shall not have been invalidated and to the fullest extent
permitted by applicable law.

      14. Definitions. Terms used herein and defined in Section 145(h) and
Section 145(i) of the DGCL shall have the respective meanings assigned to such
terms in such Section 145(h) and Section 145(i).

      NINTH. No director of the Corporation shall be liable to the Corporation
or its stockholders for monetary damages for breach of fiduciary duty as a
director, except for liability (i) for any breach of the director's duty of
loyalty to the Corporation or its stockholders, (ii) for acts or omissions not
in good faith or which involve intentional misconduct or a knowing violation of
law, (iii) under Section 174 of Title 8 of the DGCL or (iv) for any transaction
from which the director derived an improper personal benefit.

<PAGE>

      TENTH. The Corporation reserves the right to amend, alter, change or
repeal any provision contained in this Certificate of Incorporation, in the
manner now or hereafter prescribed by statute, and all rights conferred upon
stockholders herein are granted subject to this reservation.

      ELEVENTH Except as provided in the provisions establishing a class of
stock, the number of authorized shares of any class or series of stock may be
increased or decreased (but not below the number of shares thereof then
outstanding) by the affirmative vote of the holders of a majority of the capital
stock of the Corporation entitled to vote irrespective of the provisions of
Section 242(b)(2) of the DGCL.

                                      ****

<PAGE>

IN WITNESS WHEREOF, the undersigned has signed this Amended and Restated
Certificate of Incorporation on behalf of the Corporation this 7th day of
August, 2003.

                                       By: /s/ Nick Hayes
                                           -------------------------------------
                                           Name: Nick Hayes
                                           Title: Chief Operating Officer and
                                                  Chief Financial Officer
<PAGE>

                                    EXHIBIT D

                             STOCKHOLDERS AGREEMENT

<PAGE>

                                    EXHIBIT E

                               TRANSACTION WARRANT

<PAGE>

                                                     Form of Transaction Warrant

      THIS TRANSACTION WARRANT AND THE SHARES OBTAINABLE UPON ITS EXERCISE HAVE
      NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY
      STATE SECURITIES LAWS (COLLECTIVELY, THE "ACTS"), AND MAY NOT BE OFFERED,
      SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL
      REGISTERED UNDER ALL APPLICABLE ACTS OR UNLESS AN OPINION OF COUNSEL IS
      DELIVERED TO THE ISSUER IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER
      TO THE EFFECT THAT AN EXEMPTION FROM REGISTRATION IS AVAILABLE UNDER ALL
      APPLICABLE ACTS.

      THE SHARES OBTAINABLE UPON EXERCISE OF THIS TRANSACTION WARRANT SHALL BE
      SUBJECT TO CERTAIN TRANSFER RESTRICTIONS SET FORTH IN A STOCKHOLDERS
      AGREEMENT, DATED JULY [ ], 2003 BY AND AMONG THE COMPANY AND THE
      STOCKHOLDERS NAMED THEREIN, AS IT MAY BE AMENDED FROM TIME TO TIME (THE
      "STOCKHOLDERS AGREEMENT"), A COPY OF WHICH MAY BE INSPECTED AT THE
      COMPANY'S PRINCIPAL OFFICE UPON EXECUTION. THE COMPANY WILL NOT REGISTER
      THE TRANSFER OF SUCH SECURITIES ON THE BOOKS OF THE COMPANY UNLESS AND
      UNTIL THE TRANSFER HAS BEEN MADE IN COMPLIANCE WITH THE TERMS OF THE
      STOCKHOLDERS AGREEMENT.

      No. [TW-1]                                                  July [ ], 2003

                      PREDIX PHARMACEUTICALS HOLDINGS, INC.

                               TRANSACTION WARRANT

      THIS CERTIFIES THAT, for value received, [  ], or its registered assigns
(the "Holder"), is entitled to subscribe for and purchase from Predix
Pharmaceuticals Holdings, Inc., a Delaware corporation (the "Company"), at any
time prior to or upon July [ ], 2004, or, in the event such date is a Saturday,
Sunday or United States holiday, the next business day (the "Expiration Date"),
up to that number of Shares set forth on Schedule I attached hereto and at the
relevant Exercise Price (each as defined in Section 1(a) below).

      This warrant is one of a series of Transaction Warrants (each a
"Transaction Warrant," and collectively, the "Transaction Warrants") of like
tenor which may be issued to each of the holders of Preferred Stock (the
"Physiome Preferred Holders") of Physiome Sciences, Inc., a Delaware
corporation, and each of the holders of Preferred Stock (the "Predix Preferred
Holders") of Predix Pharmaceuticals Ltd. ("Predix Ltd."), an organization formed
under the laws

<PAGE>

of Israel, in connection with: (i) the recapitalization of the Company; and (ii)
the purchase by the Company of all of the issued and outstanding capital stock
of Predix Ltd., which recapitalization and share purchases are to be effected on
or about the date hereof.

      This Transaction Warrant is subject to the following terms and conditions:

      1. Shares; Exercise Price; Additional Shares.

      (a) As used herein, the term "Shares" means: (i) that number of shares of
the Company's Series B Convertible Preferred Stock, par value $.01 per share
(the "Series B Preferred Stock") set forth opposite the Holder's name on
Schedule 1 attached hereto, or (ii) in the event that the Series B Preferred
Stock shall have been mandatorily converted in accordance with its terms, and
this Transaction Warrant has not been fully exercised, "Shares" shall mean that
number of shares of the Company's new post-split Common Stock, par value $0.01
per share (the "Common Stock"), that would be issuable upon conversion of the
Series B Preferred Stock that would have been issuable under this Transaction
Warrant upon payment of the applicable Exercise Price had such mandatory
conversion not occurred, measured at the time of such conversion. The exercise
price per Share shall be equal to: (A) $8.00 (the "Initial Exercise Price"); or
(B) if, prior to the Expiration Date, the Company has not received final
acceptance by the Food and Drug Administration with respect to the Company's
Investigational New Drug Application (or a Clinical Trial Exemption that is
substantially the European equivalent thereto), $5.00 (the "Alternative Exercise
Price", the Initial Exercise Price or the Alternative Exercise Price, as the
case may be, are referred to herein as the "Exercise Price." The number of
Shares issuable under this Section 1(a) and the Exercise Price are subject to
adjustment from time to time pursuant to Section 4 and Section 5 hereof.

      (b) If a Holder exercises this Transaction Warrant prior to the Expiration
Date at the Initial Exercise Price and the exercise price per Share is
subsequently adjusted to the Alternative Exercise Price, the Holder shall be
entitled to additional Shares calculated in accordance with Section 5 herein.

      2. Exercise; Payment.

      (a) Cash Exercise. The purchase rights represented by this Transaction
Warrant may be exercised by the Holder, in whole or in part, at any time, or
from time to time, by the surrender of this Transaction Warrant (together with a
duly executed notice of exercise (the "Notice of Exercise") in the form attached
hereto as Exhibit A) at the address of the Company's principal corporate offices
set forth in Section 8 hereof, and by payment to the Company of an amount equal
to the Exercise Price multiplied by the number of the Shares being purchased,
which amount may be paid by the Holder by wire transfer or check payable to the
order of the Company. The Person in whose name any certificate representing the
Shares issuable upon any exercise of this Transaction Warrant shall be deemed to
have become the holder of record of, and shall be treated for all purposes as
the record holder of, the Shares represented thereby (and such Shares shall be
deemed to have been issued) immediately prior to the close of business on the
date or dates upon which such surrender and payment are made. As used herein,
the term "Person" means any individual or any corporation, partnership, trust,
limited liability company or other entity or organization of any kind.

                                      -2-
<PAGE>

      (b) Stock Certificates. In the event of any exercise of the rights
represented by this Transaction Warrant, as promptly as practicable on or after
the date of exercise and in any event within thirty days thereafter, the Company
at its expense shall issue and deliver to the Person or Persons entitled to
receive the same a certificate or certificates representing the number of Shares
issued upon such exercise. In the event that this Transaction Warrant is
exercised in part, as promptly as practicable on or after the date of exercise
and in any event within thirty days thereafter, the Company at its sole expense
will execute and deliver a new Transaction Warrant of like tenor exercisable for
the number of Shares for which this Transaction Warrant may then be exercised.

      (c) Taxes. The issuance of the Shares upon the exercise of this
Transaction Warrant, and the delivery of certificates or other instruments
representing such Shares, shall be made without charge to the Holder for any tax
or other charge of whatever nature in respect of such issuance and the Company
shall bear any such taxes in respect of such issuance.

      3. Stock Fully Paid; Reservation of Shares. All of the Shares issuable
upon the exercise of the rights represented by this Transaction Warrant will,
upon issuance and receipt of the Exercise Price therefor, be fully paid and
nonassessable, and free from all preemptive rights, rights of first refusal or
first offer, taxes, liens and charges of whatever nature, except as may be set
forth in that certain Stockholders Agreement (the "Stockholders Agreement") of
even date herewith by and among the Company and the Company's stockholders named
therein, with respect to the issuance thereof. During the period within which
the rights represented by this Transaction Warrant may be exercised, the Company
shall use its best efforts, including soliciting its stockholders for requisite
approval, to at all times have authorized and reserved for issuance a sufficient
number of shares of its Series B Preferred Stock, or its Common Stock if the
Series B Preferred Stock has been mandatorily converted to Common Stock, to
provide for the full exercise of the rights represented by this Transaction
Warrant. In connection with any amendment to the Company's Certificate of
Incorporation (the "Certificate of Incorporation") to effect the foregoing, the
Holder will vote all shares of the Company's capital stock held by such Holder
in favor of such amendment. The Company hereby agrees that the issuance of this
Transaction Warrant shall constitute full authority to its officers who are
charged with the duty of executing stock certificates to execute and issue the
proper certificates for Shares upon the full or each partial exercise of this
Transaction Warrant and shares of Common Stock issuable upon any conversion of
all or any portion of such Shares.

      4. Adjustment of Exercise Price and Number of Shares. The number and class
or series of Shares purchasable upon the exercise of this Transaction Warrant
and the Exercise Price therefor shall be subject to adjustment from time to time
upon the occurrence of certain events, as follows:

      (a) Adjustment for Reclassification, Consolidation or Merger. If while
this Transaction Warrant, or any portion hereof, remains outstanding and
unexpired there shall be (i) a reorganization or recapitalization (other than a
combination, reclassification, exchange or subdivision of shares otherwise
provided for herein), (ii) a merger or consolidation of the Company with or into
another Person in which the Company is not the surviving entity, or a reverse
merger in which the Company is the surviving entity but the shares of the
Company's capital stock outstanding immediately prior to the merger are
converted by virtue of the merger

                                      -3-
<PAGE>

into other property, whether in the form of securities, cash, or otherwise, or
(iii) a sale or transfer of the Company's properties and assets as, or
substantially as, an entirety to any other Person in one transaction or a series
of related transactions, then, as a part of such reorganization,
recapitalization, merger, consolidation, sale or transfer, unless otherwise
directed by the Holder, all necessary or appropriate lawful provisions shall be
made so that the Holder shall thereafter be entitled to receive upon exercise of
this Transaction Warrant, during the period specified herein and upon payment of
the Exercise Price then in effect, the greatest number of shares of stock or
other securities or property that a holder of the Shares deliverable upon
exercise of this Transaction Warrant would have been entitled to receive in such
reorganization, recapitalization, consolidation, merger, sale or transfer if
this Transaction Warrant had been exercised immediately prior to such
reorganization, recapitalization, merger, consolidation, sale or transfer, all
subject to further adjustment as provided in this Section 4. If the per Share
consideration payable to the Holder for Shares in connection with any such
transaction is in a form other than cash or marketable securities, then the
value of such consideration shall be determined in good faith by the Company's
Board of Directors. The foregoing provisions of this paragraph shall similarly
apply to successive reorganizations, recapitalizations, consolidations, mergers,
sales and transfers and to the stock or securities of any other corporation that
are at the time receivable upon the exercise of this Transaction Warrant. In all
events, appropriate adjustment shall be made in the application of the
provisions of this Transaction Warrant (including adjustment of the Exercise
Price and number of Shares purchasable pursuant to the terms and conditions of
this Transaction Warrant) with respect to the rights and interests of the Holder
after the transaction, to the end that the provisions of this Transaction
Warrant shall be applicable after that event, as near as reasonably may be, in
relation to any shares or other property deliverable or issuable after such
reorganization, recapitalization, merger, consolidation, sale or transfer upon
exercise of this Transaction Warrant.

      (b) Adjustments for Split, Subdivision or Combination of Shares. If the
Company at any time while this Transaction Warrant, or any portion hereof,
remains outstanding and unexpired shall split or subdivide any class of
securities as to which purchase rights under this Transaction Warrant exist,
into a different number of securities of the same class, the number of shares of
such class issuable upon exercise of this Transaction Warrant immediately prior
to such split or subdivision shall be proportionately adjusted and the Exercise
Price for such class of securities shall be proportionately adjusted. If the
Company at any time while this Transaction Warrant, or any portion hereof,
remains outstanding and unexpired shall combine any class of securities as to
which purchase rights under this Transaction Warrant exist, into a different
number of securities of the same class, the number of shares of such class
issuable upon exercise of this Transaction Warrant immediately prior to such
combination shall be proportionately adjusted and the Exercise Price for such
class of securities shall be proportionately adjusted.

      (c) Adjustments for Dividends in Stock or Other Securities or Property. If
while this Transaction Warrant, or any portion hereof, remains outstanding and
unexpired, the holders of any class of securities as to which purchase rights
under this Transaction Warrant exist at the time shall have received, or, on or
after the record date fixed for the determination of eligible stockholders,
shall have become entitled to receive, without payment therefor, other or
additional stock or other securities or property (other than cash) of the
Company by way of dividend, then and in each case, this Transaction Warrant
shall represent the right to acquire, in addition to the number of shares of
such class of security receivable upon exercise of this Transaction Warrant,

                                      -4-
<PAGE>

and without payment of any additional consideration therefor, the amount of such
other or additional stock or other securities or property (other than cash) of
the Company that such holder would hold on the date of such exercise had it been
the holder of record of the class of security receivable upon exercise of this
Transaction Warrant on the date hereof and had thereafter, during the period
from the date hereof to and including the date of such exercise, retained such
shares and/or all other additional stock available by it as aforesaid during
said period, giving effect to all adjustments called for during such period by
the provisions of this Section 4.

      (d) Further Adjustments. In case at any time or from time to time the
Company shall take any action that affects the Shares, other than an action
described herein, then, unless such action will not have a materially adverse
effect upon the rights of the Holder, the number of Shares into which this
Transaction Warrant is exercisable shall be adjusted in such a manner and at
such time as shall be equitable in the circumstances.

      (e) Notice of Adjustments. Upon any adjustment of the Exercise Price and
any increase or decrease in the number of Shares purchasable upon the exercise
of this Transaction Warrant, then, and in each such case, the Company, within 30
days thereafter, shall give written notice thereof to the Holder at the address
of such Holder as shown on the books of the Company which notice shall state the
Exercise Price as adjusted and, if applicable, the increased or decreased number
of Shares purchasable upon the exercise of this Transaction Warrant, setting
forth in reasonable detail the method of calculation of each.

      5. Adjustment of Shares. In the event a Holder exercises this Transaction
Warrant for Shares prior to the Expiration Date at the Initial Exercise Price
and the exercise price per Share is later adjusted to the Alternative Exercise
Price pursuant to the terms of Section 1(a)(B) above, such Holder shall be
entitled to that number of additional Shares calculated by multiplying the
number of Shares originally issued to such Holder by 0.60. As promptly as
practicable on or after the date of the Expiration Date, and in any event within
thirty days thereafter, the Company at its expense shall issue and deliver to
the Person or Persons entitled to receive the same a certificate or certificates
representing such additional number of Shares.

      6. Transfers, etc.

      (a) At any time prior to the Expiration Date, each of the Transaction
Warrants issued on the date hereof shall only be transferable to: (i) in the
case of Transaction Warrants held by Physiome Preferred Holders, to other
Physiome Preferred Holders; (ii) in the case of Transaction Warrants held by
Predix Preferred Holders, to other Predix Preferred Holders; and (iii) in the
case of Transaction Warrants held by either Physiome Preferred Holders or Predix
Preferred Holders that at the date of issuance of this Transaction Warrant were
organized as a corporation, partnership or other business entity, for the
primary purpose of conducting venture fund financings, to any Affiliate (as
defined below) thereof (each transferee pursuant to clause (i), (ii) and (iii)
above, shall be referred to as a "Permitted Transferee"); and, provided further,
that any such transfer does not increase the total number of holders of
Transaction Warrants by more than one (taking into account all prior transfers
of any one Transaction Warrant) and will not increase the total number of
stockholders of the Company by more than one (taking into account all prior
transfers of any one Transaction Warrant). For purposes of this Transaction
Warrant, "Affiliate" of a Holder shall mean any of the stockholders,
subsidiaries, officers, directors, members or

                                      -5-
<PAGE>

partners of such Holder, and any other corporation, partnership or other
business entity which directly or indirectly controls, is controlled by or is
under common control with, such Holder.

      (b) Any transfer pursuant to Section 6(a) shall be effected upon surrender
of this Transaction Warrant with a properly executed assignment (in the form
attached hereto as Exhibit B) at the principal office of the Company (or, if
another office or agency has been designated by the Company for such purpose,
then at such other office or agency).

      7. Right to Purchase Additional Shares.

      (a) In the event a Physiome Preferred Holder (or a Permitted Transferee of
such Holder) fails to exercise this Transaction Warrant in full prior to the
Expiration Date, the right to purchase the Shares underlying this Transaction
Warrant (the "Physiome Remaining Warrant Shares") shall be offered on a pro rata
basis to all other Physiome Preferred Holders (the "Physiome Participating
Purchasers") who fully exercised their respective Transaction Warrants, subject
to the terms and conditions set forth below. Each such Physiome Participating
Purchaser's pro rata share shall equal a fraction of the aggregate Physiome
Remaining Warrant Shares, the numerator of which is the number of shares of the
Company's Common Stock plus the number of shares of the Company's Common Stock
issued or issuable upon conversion of the Company's Preferred Stock held by such
Physiome Participating Purchaser at the time such offer is made to all other
Physiome Preferred Holders, and the denominator of which is the total number of
shares of the Company's Common Stock plus the number of shares of the Company's
Common Stock issued or issuable upon conversion of the Company's Preferred Stock
held by all Physiome Participating Purchasers at the time such offer is made to
all other Physiome Preferred Holders. Within five days of the Expiration Date,
the Company shall give each Physiome Participating Purchaser written notice (the
"Physiome Rights Notice") describing the number of Physiome Remaining Warrant
Shares that such Physiome Participating Purchaser has the right to purchase
under this Section 7(a), together with the applicable Exercise Price. Each such
Physiome Participating Purchaser shall have ten (10) days from delivery of the
Physiome Rights Notice to agree to purchase (i) all or any part of its pro rata
share of such Physiome Remaining Warrant Shares and (ii) all or any part of the
pro rata share of any other Physiome Participating Purchasers to the extent that
such Physiome Participating Purchasers do not elect to purchase their full pro
rata share, upon the general terms specified in the Physiome Rights Notice, by
giving written notice to the Company setting forth the quantity of Physiome
Remaining Warrant Shares to be purchased. If the Physiome Participating
Purchasers who elect to purchase their full pro rata share also elect to
purchase in the aggregate more than 100% of the Physiome Remaining Warrant
Shares, such Physiome Remaining Warrant Shares shall be sold to such Physiome
Participating Purchasers in accordance with their respective pro rata share. A
failure to provide the Company with written notice setting forth the quantity of
Physiome Remaining Warrant Shares to be purchased by any such Physiome
Participating Purchaser in accordance with this Section 7(a) shall be deemed to
be a waiver by such Physiome Participating Purchaser of its right to purchase
any portion of its pro rata portion of such Physiome Remaining Warrant Shares.
At the end of the period specified in the Physiome Rights Notice, if any
Physiome Remaining Warrant Shares remain unallocated (the "Final Physiome
Warrant Shares"), such

                                      -6-
<PAGE>

Final Physiome Warrant Shares shall be offered, in accordance with the terms set
forth in Section 7(c) below, to each Predix Participating Purchaser who elects
to purchase all or any part of its pro rata share of the Predix Remaining
Warrant Shares (the "Predix Final Purchasers").

      (b) In the event a Predix Preferred Holder (or a Permitted Transferee of
such Holder) fails to exercise this Transaction Warrant in full prior to the
Expiration Date, the right to purchase the Shares underlying this Transaction
Warrant (the "Predix Remaining Warrant Shares") shall be offered on a pro rata
basis to all other Predix Preferred Holders (the "Predix Participating
Purchasers") who fully exercised their respective Transaction Warrants, subject
to the terms and conditions set forth below. Each such Predix Participating
Purchaser's pro rata share shall equal a fraction of the aggregate Predix
Remaining Warrant Shares, the numerator of which is the number of shares of the
Company's Common Stock plus the number of shares of the Company's Common Stock
issued or issuable upon conversion of the Company's Preferred Stock held by such
Predix Participating Purchaser at the time such offer is made to all other
Predix Preferred Holders, and the denominator of which is the total number of
shares of the Company's Common Stock plus the number of shares of the Company's
Common Stock issued or issuable upon conversion of the Company's Preferred Stock
held by all Predix Participating Purchasers at the time such offer is made to
all other Predix Preferred Holders. Within five days of the Expiration Date, the
Company shall give each Predix Participating Purchaser written notice (the
"Predix Rights Notice") describing the number of Predix Remaining Warrant Shares
that such Predix Participating Purchaser has the right to purchase under this
Section 7(b), together with applicable Exercise Price. Each such Predix
Participating Purchaser shall have ten (10) days from delivery of the Predix
Rights Notice to agree to purchase (i) all or any part of its pro rata share of
such Predix Remaining Warrant Shares and (ii) all or any part of the pro rata
share of any other Predix Participating Purchasers to the extent that such
Predix Participating Purchasers do not elect to purchase their full pro rata
share, upon the general terms specified in the Predix Rights Notice, by giving
written notice to the Company setting forth the quantity of Predix Remaining
Warrant Shares to be purchased. If the Predix Participating Purchasers who elect
to purchase their full pro rata share also elect to purchase in the aggregate
more than 100% of the Predix Remaining Warrant Shares, such Predix Remaining
Warrant Shares shall be sold to such Predix Participating Purchasers in
accordance with their respective pro rata share. A failure to provide the
Company with written notice setting forth the quantity of Predix Remaining
Warrant Shares to be purchased by any such Predix Participating Purchaser in
accordance with this Section 7(b) shall be deemed to be a waiver by such Predix
Participating Purchaser of its right to purchase any portion of its pro rata
portion of such Predix Remaining Warrant Shares. At the end of the period
specified in the Predix Rights Notice, if any Predix Remaining Warrant Shares
remain unallocated (the "Final Predix Warrant Shares"), such Final Predix
Warrant Shares shall be offered, in accordance with the terms set forth in
Section 7(d) below, to each Physiome Participating Purchaser who elects to
purchase all or any part of its pro rata share of the Physiome Remaining Warrant
Shares (the "Physiome Final Purchasers").

      (c) At the end of the ten-day period specified in the Physiome Rights
Notice, the Company shall give each Predix Final Purchaser written notice (the
"Final Predix Rights Notice") describing the number of Final Physiome Warrant
Shares that such Predix Final Purchaser has the right to purchase under this
Section 7(c). Each such Predix Final Purchaser shall have ten (10) days from
delivery of the Final Predix Rights Notice to agree to purchase (i) all or any
part of its pro rata share of such Final Physiome Warrant Shares and (ii) all or
any

                                      -7-
<PAGE>

part of the pro rata share of any other Predix Final Purchasers to the extent
that such Predix Final Purchasers do not elect to purchase their full pro rata
share, upon the general terms specified in the Final Predix Rights Notice, by
giving written notice to the Company setting forth the quantity of Final
Physiome Warrant Shares to be purchased. If the Predix Final Purchasers who
elect to purchase their full pro rata share also elect to purchase in the
aggregate more than 100% of the Final Physiome Warrant Shares, such Final
Physiome Warrant Shares shall be sold to such Predix Final Purchasers in
accordance with their respective pro rata share. A failure to provide the
Company with written notice setting forth the quantity of Final Physiome Warrant
Shares to be purchased by any such Predix Final Purchaser in accordance with
this Section 7(c) shall be deemed to be a waiver by such Predix Final Purchaser
of its right to purchase any portion of its pro rata portion of such Final
Physiome Warrant Shares. At the end of the period specified in the Final Predix
Rights Notice, if any Final Physiome Warrant Shares remain unallocated, the
right to purchase such Final Physiome Warrant Shares shall expire.

      (d) At the end of the ten-day period specified in the Predix Rights
Notice, the Company shall give each Physiome Final Purchaser written notice (the
"Final Physiome Rights Notice") describing the number of Final Predix Warrant
Shares that such Physiome Final Purchaser has the right to purchase under this
Section 7(d). Each such Physiome Final Purchaser shall have ten (10) days from
delivery of the Final Physiome Rights Notice to agree to purchase (i) all or any
part of its pro rata share of such Final Predix Warrant Shares and (ii) all or
any part of the pro rata share of any other Physiome Final Purchasers to the
extent that such Physiome Final Purchasers do not elect to purchase their full
pro rata share, upon the general terms specified in the Final Physiome Rights
Notice, by giving written notice to the Company setting forth the quantity of
Final Predix Warrant Shares to be purchased. If the Physiome Final Purchasers
who elect to purchase their full pro rata share also elect to purchase in the
aggregate more than 100% of the Final Predix Warrant Shares, such Final Predix
Warrant Shares shall be sold to such Physiome Final Purchasers in accordance
with their respective pro rata share. A failure to provide the Company with
written notice setting forth the quantity of Final Predix Warrant Shares to be
purchased by any such Physiome Final Purchaser in accordance with this Section
7(d) shall be deemed to be a waiver by such Physiome Final Purchaser of its
right to purchase any portion of its pro rata portion of such Final Predix
Warrant Shares. At the end of the period specified in the Final Physiome Rights
Notice, if any Final Predix Warrant Shares remain unallocated, the right to
purchase such Final Predix Warrant Shares shall expire.

      (e) The closing of the purchase, if any, of Physiome Remaining Warrant
Shares, Final Physiome Warrant Shares, Predix Remaining Warrant Shares or Final
Predix Warrant Shares, as applicable, by the Holders exercising their rights
hereunder shall take place at such location, date and time as the parties shall
agree, but not later than August [ ], 2004. At the closing, the Company shall
deliver to such Holders certificates representing all of the Physiome Remaining
Warrant Shares, Final Physiome Warrant Shares, Predix Remaining Warrant Shares
or Final Predix Warrant Shares, as applicable. At the closing, such purchasing
Holders shall deliver to the Company (i) payment for the Physiome Remaining
Warrant Shares, Final Physiome Warrant Shares, Predix Remaining Warrant Shares
or Final Predix Warrant Shares, as applicable, and (ii) at the request of the
Company, a duly executed certificate reasonably satisfactory to the Company
containing such representations and warranties of the purchasing Holders with
respect to federal and state securities laws. The certificates representing the
Physiome Remaining Warrant Shares, Final Physiome Warrant Shares, Predix
Remaining

                                      -8-
<PAGE>

Warrant Shares or Final Predix Warrant Shares, as applicable, may contain a
legend stating that they are issued subject to the registration requirements of
the Securities Act of 1933, as amended (the "Securities Act"), and applicable
state securities laws.

      8. Notices.

      (a) All notices, requests, consents, and other communications under this
Transaction Warrant shall be in writing and shall be deemed delivered (i) seven
business days after being sent by registered or certified mail, return receipt
requested, postage prepaid or (ii) three business days after being sent via a
reputable nationwide overnight courier service guaranteeing next business day
delivery, in each case to the intended recipient as set forth below:

      If to the Company, at 150 College Road West, Suite 300, Princeton, New
Jersey 08540-6604, Attention: Chief Operating Officer, or at such other address
as may have been furnished in writing by the Company to the Holder, with a copy
to Hale and Dorr LLP, 650 College Road East, Princeton, New Jersey 08540,
Attention: Richard S. Mattessich, Esq.; or

      If to a Holder, at its address set forth on the signature page hereto, or
at such other address as may be furnished in writing by such Holder to the
Company.

      (b) Either party may give any notice, request, consent or other
communication under this Transaction Warrant using any other means (including,
without limitation, personal delivery, messenger service, telecopy, first class
mail or electronic mail), but no such notice, request, consent or other
communication shall be deemed to have been duly given unless and until it is
actually received by the party for whom it is intended. Either party may change
the address to which notices, requests, consents or other communications
hereunder are to be delivered by giving the other party notice in the manner set
forth in this Section.

      9. Legends. Each certificate evidencing the Shares issued upon exercise of
this Transaction Warrant, or transfer of such Shares (other than a transfer
registered under the Securities Act, or any subsequent transfer of Shares so
registered) shall be stamped or imprinted with legends substantially in the
following forms:

      THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
      UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR THE
      SECURITIES LAWS OF ANY STATE. THE SECURITIES MAY NOT BE TRANSFERRED EXCEPT
      PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT AND
      APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN APPLICABLE EXEMPTION
      FROM THE REGISTRATION REQUIREMENTS OF SUCH ACT AND SUCH LAWS.

      THE SHARES OF STOCK REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO A
      STOCKHOLDERS AGREEMENT, AS MAY BE AMENDED FROM TIME TO TIME, BY AND AMONG
      THE

                                      -9-
<PAGE>

      REGISTERED OWNER OF THIS CERTIFICATE, THE COMPANY AND CERTAIN OTHER
      STOCKHOLDERS OF THE COMPANY, A COPY OF WHICH IS AVAILABLE FOR INSPECTION
      AT THE OFFICES OF THE SECRETARY OF THE COMPANY.

      10. Fractional Shares. No fractional Shares will be issued in connection
with any exercise hereunder. Instead, the Company shall pay to such Holder an
amount in cash equal to any fractional share to which such Holder would be
entitled, multiplied by the Fair Market Value of a Share, as determined in good
faith by the Company's Board of Directors. For purposes of this Section 10, the
Fair Market Value of one Share shall equal: (a) the average of the closing sale
price of the Series B Preferred Stock (or any other security for which this
Transaction Warrant is then exercisable) as quoted on the Nasdaq Stock Market or
in the Over-The-Counter Market Summary or the closing price quoted on any
national securities exchange on which such securities are listed, whichever is
applicable, as reported in The Wall Street Journal for the ten trading days
immediately prior to the date of determination of Fair Market Value (or, if no
sales take place on any such trading day, the average of the closing bid and
asked prices on such trading day); or (b) if the Series B Preferred Stock (or
any other security for which this Transaction Warrant is then exercisable) is
not quoted on the Nasdaq Stock Market or Over-The-Counter or on a national
securities exchange, the Fair Market Value of a Share shall be established in
good faith by the Company's Board of Directors.

      11. Representations and Warranties of the Company. The Company hereby
represents and warrants to the Holder as follows:

      (a) This Transaction Warrant has been duly authorized and executed by the
Company and is a valid and binding obligation of the Company enforceable in
accordance with its terms;

      (b) The Company shall use its best efforts to ensure that the Shares have
been duly authorized and reserved for issuance by the Company and, when issued
in accordance with the terms hereof, will be validly issued, fully paid and
nonassessable, and free from all preemptive rights, rights of first refusal or
first offer, taxes, liens and charges of whatever nature, except as may set
forth in the Stockholders Agreement; and

      (c) The execution and delivery of this Transaction Warrant are not, and
the issuance of the Shares upon exercise of this Transaction Warrant in
accordance with the terms hereof will not be, inconsistent with the Company's
Certificate of Incorporation, as then in effect, and the Company's by-laws (the
"By-Laws"), as then in effect.

      12. Representations and Warranties by the Holder. The Holder represents
and warrants to the Company as follows:

      (a) This Transaction Warrant is being acquired for its own account, for
investment and not with a view to, or for resale in connection with, any
distribution thereof within the meaning of the Securities Act. Upon exercise of
this Transaction Warrant, the Holder shall, if so requested by the Company,
confirm in writing, in a form reasonably satisfactory to the Company, that the
Shares issuable upon exercise of this Transaction Warrant are being acquired for
investment and not with a view toward distribution or resale that would violate
the Securities Act.

                                      -10-
<PAGE>

      (b) The Holder understands that the Transaction Warrant and the Shares
have not been registered under the Securities Act by reason of their issuance in
a transaction exempt from the registration and prospectus delivery requirements
of the Securities Act pursuant to Section 4(2) thereof, and that they must be
held by the Holder indefinitely, and that the Holder must therefore bear the
economic risk of such investment indefinitely, unless a subsequent disposition
thereof is registered under the Securities Act or is exempted from such
registration.

      (c) The Holder has such knowledge and experience in financial and business
matters that it is capable of evaluating the merits and risks of the purchase of
this Transaction Warrant and the Shares purchasable pursuant to the terms of
this Transaction Warrant and of protecting its interests in connection
therewith.

      (d) The Holder is able to bear the economic risk of the purchase of the
Shares pursuant to the terms of this Transaction Warrant.

      (e) The Holder is an "accredited investor" within the meaning of Rule 501
of Regulation D under the Securities Act.

      13. Rights of Stockholders. Subject to Section 4 hereof, no Holder, as
such, shall be entitled to vote or receive dividends or be deemed the holder of
the Shares or any other securities of the Company that may at any time be
issuable on the exercise hereof for any purpose, nor shall anything contained
herein be construed to confer upon the Holder, as such, any of the rights of a
stockholder of the Company or any right to vote for the election of directors or
upon any matter submitted to stockholders at any meeting thereof, or to give or
withhold consent to any corporate action (whether upon any recapitalization,
issuance of stock, reclassification of stock, change of par value,
consolidation, merger, conveyance, or otherwise) or to receive notice of
meetings, or to receive dividends or subscription rights or otherwise until this
Transaction Warrant shall have been exercised and the Shares purchasable upon
the exercise hereof shall have become issuable, as provided herein.

      14. Expiration of Warrant. Subject to the provisions of Section 7, this
Transaction Warrant shall expire and shall no longer be exercisable as of 5:00
p.m., Eastern Time, on July [ ], 2004.

      15. Miscellaneous.

      (a) This Transaction Warrant shall be governed by and construed for all
purposes under and in accordance with the laws of the State of Delaware without
regard to principles of conflicts of law.

      (b) The headings in this Transaction Warrant are for purposes of reference
only, and shall not limit or otherwise affect any of the terms hereof.

      (c) The representations, warranties, covenants and conditions of the
respective parties contained herein or made pursuant to this Transaction Warrant
shall survive the execution and delivery of this Transaction Warrant.

                                      -11-
<PAGE>

      (d) The terms of this Transaction Warrant shall be binding upon and shall
inure to the benefit of any successors or assigns of the Company and of the
Holder and of the Shares issued or issuable upon the exercise hereof.

      (e) This Transaction Warrant and the other documents delivered pursuant
hereto constitute the full and entire understanding and agreement between the
parties with regard to the subjects hereof and thereof.

      (f) The Company shall not, by amendment of its Certificate of
Incorporation or By-Laws, or through any other means, directly or indirectly,
avoid or seek to avoid the observance or performance of any of the terms of this
Transaction Warrant and shall at all times in good faith assist in the carrying
out of all such terms and in the taking of all such action as may be necessary
or appropriate in order to protect the rights of the Holder against impairment.

      (g) Upon receipt of evidence reasonably satisfactory to the Company of the
loss, theft, destruction or mutilation of this Transaction Warrant and, in the
case of any such loss, theft or destruction, upon delivery of an indemnity
agreement reasonably satisfactory in form and amount to the Company or, in the
case of any such mutilation, upon surrender and cancellation of such Transaction
Warrant, the Company, at its expense, will execute and deliver to the Holder, in
lieu thereof, a new Transaction Warrant of like date and tenor.

      (h) This Transaction Warrant and any provision hereof may be amended,
waived or terminated only by an instrument in writing signed by the Company and
the Holder.

                            [Signature Page Follows]

                                      -12-
<PAGE>

IN WITNESS WHEREOF, the Company has caused this Transaction Warrant to be signed
by its duly authorized officer.

                                           Predix Pharmaceuticals Holdings, Inc.

                                           By __________________________________
                                              Name:
                                              Title:

Acknowledged and Accepted:

[                     ]

By __________________________
   Name:
   Title:
   Address:

<PAGE>

                                   SCHEDULE 1

<TABLE>
<CAPTION>
                              NUMBER OF SHARES OF SERIES B
                              PREFERRED STOCK PURCHASABLE             NUMBER OF SHARES OF SERIES B
                                 UPON EXERCISE OF THIS              PREFERRED STOCK PURCHASABLE UPON
                              TRANSACTION WARRANT AT $8.00        EXERCISE OF THIS TRANSACTION WARRANT
HOLDER                                 PER SHARE                           AT $5.00 PER SHARE
------                        ------------------------------      ---------------------------------------
<S>                           <C>                                 <C>
</TABLE>

<PAGE>

                                                                       EXHIBIT A

                               NOTICE OF EXERCISE

TO:   Predix Pharmaceuticals Holdings, Inc.
           Attention: President

      1. The undersigned hereby elects to purchase _____________________shares
of:

            (i) Series B Preferred Stock; or

            (ii) Class A Common Stock, if the Series B Preferred Stock has been
mandatorily converted to Class A Common Stock; of Predix Pharmaceuticals
Holdings, Inc. pursuant to the terms of this Transaction Warrant, and tenders
herewith payment of the purchase price of such shares in full.

      2. Please issue a certificate or certificates representing said securities
in the name of the undersigned or in such other name as is specified below:

                           ___________________________
                                     (Name)

                           ___________________________

                           ___________________________
                                    (Address)

      3. The undersigned hereby represents and warrants that the aforesaid
securities are being acquired for the account of the undersigned for investment
and not with a view to, or for resale, in connection with the distribution
thereof, and that the undersigned has no present intention of distributing or
reselling such shares and all representations and warranties of the undersigned
set forth in Section 12 of the attached Transaction Warrant are true and correct
as of the date hereof.

                                                     ___________________________
                                                     (Signature and Date)

<PAGE>

                                                                       EXHIBIT B

                               FORM OF ASSIGNMENT

                  (To be executed by the Holder if such Holder
                  desires to transfer the Transaction Warrant)

FOR VALUE RECEIVED ____________________________________________ (the
"Transferor") hereby sells, assigns and transfers unto
_____________________________________________________________ (the "Transferee")

                  (Please print name and address of transferee)

this Transaction Warrant, together with all right, title and interest therein,
and does hereby irrevocably constitute and appoint ___________________________
as its Attorney to transfer the such Transaction Warrant on the books of Predix
Pharmaceuticals Holdings, Inc., with full power of substitution. The Transferor
has provided a written instrument to the Company notifying the Company of such
transfer and pursuant to which the Transferee hereunder has agreed in writing to
be bound by the terms of the Transaction Warrant dated July [ ], 2003 issued by
Predix Pharmaceuticals Holdings, Inc., a Delaware corporation, a copy of which
has been provided to the Transferee by the Transferor.

Dated:                     Signature ___________________________________________
                                     (Signature must conform in all respects
                                     to name of Holder as specified on the
                                     face of the Transaction Warrant)

                                     ___________________________________________
                                     (Insert Social Security or other
                                     Identifying Number of Holder)

<PAGE>

                                    EXHIBIT F

                                 FUNDING WARRANT

<PAGE>

                                                         Form of Funding Warrant

      THIS FUNDING WARRANT HAS NOT BEEN AND THE SHARES OBTAINABLE UPON ITS
      EXERCISE WILL NOT BE REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
      AMENDED, OR ANY STATE SECURITIES LAWS (COLLECTIVELY, THE "ACTS"), AND MAY
      NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, PLEDGED OR HYPOTHECATED
      UNLESS AND UNTIL REGISTERED UNDER ALL APPLICABLE ACTS OR UNLESS AN OPINION
      OF COUNSEL IS DELIVERED TO THE ISSUER IN FORM AND SUBSTANCE SATISFACTORY
      TO THE ISSUER TO THE EFFECT THAT AN EXEMPTION FROM REGISTRATION IS
      AVAILABLE UNDER ALL APPLICABLE ACTS.

      THE SHARES OBTAINABLE UPON EXERCISE OF THIS FUNDING WARRANT SHALL BE
      SUBJECT TO CERTAIN TRANSFER RESTRICTIONS SET FORTH IN A STOCKHOLDERS
      AGREEMENT, DATED JULY [ ], 2003 BY AND AMONG THE COMPANY AND THE
      STOCKHOLDERS NAMED THEREIN, AS IT MAY BE AMENDED FROM TIME TO TIME (THE
      "STOCKHOLDERS AGREEMENT"), A COPY OF WHICH MAY BE INSPECTED AT THE
      COMPANY'S PRINCIPAL OFFICE UPON EXECUTION. THE COMPANY WILL NOT REGISTER
      THE TRANSFER OF SUCH SECURITIES ON THE BOOKS OF THE COMPANY UNLESS AND
      UNTIL THE TRANSFER HAS BEEN MADE IN COMPLIANCE WITH THE TERMS OF THE
      STOCKHOLDERS AGREEMENT.

No. [FW-1]                                                        July [ ], 2003

                      PREDIX PHARMACEUTICALS HOLDINGS, INC.

                                 FUNDING WARRANT

      THIS CERTIFIES THAT, for value received, [  ], or its registered assigns
(the "Holder"), is entitled to subscribe for and purchase from Predix
Pharmaceuticals Holdings, Inc., a Delaware corporation (the "Company"), at any
time prior to or upon July [ ], 2008, or, in the event such date is a Saturday,
Sunday or United States holiday, the next business day (the "Expiration Date"),
the Shares at the Exercise Price (each as defined in Section 1(a) below).

      This warrant is one of a series of Funding Warrants (each a "Funding
Warrant," and collectively, the "Funding Warrants") of like tenor which may be
issued to each of the holders of Preferred Stock (the "Physiome Preferred
Holders") of Physiome Sciences, Inc., a Delaware

                                       1
<PAGE>

corporation, and each of the holders of Preferred Stock (the "Predix Preferred
Holders") of Predix Pharmaceuticals Ltd. ("Predix Ltd."), an organization formed
under the laws of Israel, in connection with: (i) the recapitalization of the
Company; and (ii) the purchase by the Company of all of the issued and
outstanding capital stock of Predix Ltd., which recapitalization and share
purchases are to be effected on or about the date hereof.

      This Funding Warrant is subject to the following terms and conditions:

      1. Shares; Exercise Price; Cancellation.

      (a) As used herein, the term "Shares" means that number of shares (or
other applicable denomination) of Subsequent Financing Securities issued in a
Subsequent Financing (each as defined in Section 1(b) below) equal to the
Holder's Pro Rata Share (as defined in Section 1(c) below) of such Subsequent
Financing Securities at the per share (or other applicable denomination) price
at which such Subsequent Financing Securities are first sold (the "Exercise
Price").

      (b) As used herein, the term "Subsequent Financing" means the consummation
of a sale by the Company after the date hereof of capital stock of the Company
to a third party investor, or of securities convertible into or exchangeable for
such capital stock, or any options, warrants or rights to purchase such capital
stock or securities (collectively, "Subsequent Financing Securities")
(excluding: (i) issuances of shares of capital stock of the Company upon
exercise of any options, warrants or rights to purchase such capital stock that
are outstanding on the date hereof or upon conversion of any securities
convertible into or exchangeable for shares of such capital stock that are
outstanding on the date hereof; (ii) the issuance and exercise of Transaction
Warrants and Funding Warrants issued to Physiome Preferred Holders and Predix
Preferred Holders on the date hereof (and the issuance of any shares upon
conversion of any shares issued upon exercise of such Transaction Warrants and
Funding Warrants); (iii) shares of capital stock issuable or issued to
employees, consultants, officers or directors of the Company either directly or
pursuant to a stock option plan or other incentive plan approved by the Board of
Directors of the Company, where such issuance is approved by the Board of
Directors of the Company or a committee designated by the Board of Directors;
and (iv) shares of capital stock issuable or issued (A) to equipment lessors or
equipment vendors in connection with any equipment lease financing by the
Company, (B) in connection with a strategic commercial transaction (i.e., with a
primary purpose other than that of providing financing), licensing transaction
or any debt financing with a financial institution or other strategic financing,
as determined by the Board of Directors of the Company, or (C) in connection
with a business acquisition of or by the Company, whether by merger,
consolidation, purchase of assets, purchase or exchange of stock with a primary
purpose other than that of providing financing).

      (c) For purposes of this Section 1, "Pro Rata Share" shall equal a
fraction of the aggregate Subsequent Financing Securities to be issued to a
third party or parties in each Subsequent Financing, the numerator of which is
the number of shares of the Company's Common Stock, par value $0.01 per share
(the "Common Stock"), issuable upon conversion of the Company's Preferred Stock
held by such Holder on July [ ], 2003, and the denominator of which is the total
number of shares of the Company's Common Stock issuable upon conversion of then
outstanding shares of the Company's Preferred Stock on such date. For purposes
of

                                      -2-
<PAGE>

clarification, the aggregate Subsequent Financing Securities issued to
holders of Funding Warrants shall be issued in addition to those Subsequent
Financing Securities issued to third party investors. For example, if the
Company plans to effect a Subsequent Financing pursuant to which $5.0 million of
Subsequent Financing Securities shall be issued to third party investors and the
Pro Rata Share of all holders of Funding Warrants exercising such Warrants
equals $2.5 million, the aggregate value of Subsequent Financing Securities
issued in such Subsequent Financing shall equal $7.5 million.

      (d) In the event a Holder (or a Permitted Transferee of such Holder (as
defined in Section 3(a) below)) fails to exercise this Funding Warrant in full
in connection with any Subsequent Financing prior to the Expiration Date, the
right to purchase Shares underlying this Funding Warrant in connection with such
a Subsequent Financing shall be offered in accordance with Section 4 herein, and
thereafter, this Funding Warrant shall be immediately cancelled and shall not be
exercisable in any Subsequent Financings.

      2. Exercise; Payment. In the event the Company intends to effect a
Subsequent Financing, it shall provide each Holder with written notice (the
"Subsequent Financing Notice"), which notice shall describe the general terms of
the Subsequent Financing. Each Holder shall have ten (10) days from the date of
delivery of the Subsequent Financing Notice to exercise its purchase rights
hereunder. The purchase rights represented by this Funding Warrant may be
exercised by the Holder or a Permitted Transferee, in whole or in part, by
delivery of a duly executed notice of exercise (the "Notice of Exercise") in the
form attached hereto as Exhibit A, at the address of the Company's principal
corporate offices set forth in Section 5 hereof, and by payment to the Company
of an amount equal to the Exercise Price multiplied by the number of the Shares
being purchased, which amount shall be paid at the closing of each Subsequent
Financing, at the election of the Holder, by wire transfer or check payable to
the order of the Company. The Person in whose name any certificate representing
the Shares issuable upon any exercise of this Funding Warrant shall be deemed to
have become the holder of record of, and shall be treated for all purposes as
the record holder of, the Shares represented thereby (and such Shares shall be
deemed to have been issued) on the date or dates of such closing and upon which
such delivery and payment are made. As used herein, the term "Person" means any
individual or any corporation, partnership, trust, limited liability company or
other entity or organization of any kind.

      3. Transfers, etc.

      (a) At any time prior to the Expiration Date, each of the Funding Warrants
issued on the date hereof shall only be transferable to: (i) in the case of
Funding Warrants held by Physiome Preferred Holders, to other Physiome Preferred
Holders; (ii) in the case of Funding Warrants held by Predix Preferred Holders
to other Predix Preferred Holders; and (iii) in the case of Funding Warrants
held by either Physiome Preferred Holders or Predix Preferred Holders that at
the date of issuance of this Funding Warrant were organized as a corporation,
partnership or other business entity, for the primary purpose of conducting
venture fund financings, to any Affiliate (as defined below) thereof (each
transferee pursuant to clause (i), (ii) and (iii) above, shall be referred to as
a "Permitted Transferee"); and, provided further, that any such transfer does
not increase the total number of holders of Funding Warrants by more than one
(taking into account all prior transfers of any one Funding Warrant) and will
not increase the total number of

                                      -3-
<PAGE>

stockholders of the Company by more than one (taking into account all prior
transfers of any one Funding Warrant). For purposes of this Funding Warrant,
"Affiliate" of a Holder shall mean any of the stockholders, subsidiaries,
officers, directors, members or partners of such Holder, and any other
corporation, partnership or other business entity which directly or indirectly
controls, is controlled by or is under common control with, such Holder.

      (b) Any transfer pursuant to Section 3(a) shall be effected upon surrender
of this Funding Warrant with a properly executed assignment (in the form
attached hereto as Exhibit B) at the principal office of the Company (or, if
another office or agency has been designated by the Company for such purpose,
then at such other office or agency).

      4. Right to Purchase Additional Shares.

      (a) In the event a Physiome Preferred Holder (or a Permitted Transferee of
such Holder) fails to exercise this Funding Warrant in full in connection with
each Subsequent Financing prior to the Expiration Date (in addition to the
cancellation of the Holder's future rights under this Transaction Warrant set
forth in Section 1(d)), the right to purchase the Shares underlying this Funding
Warrant (the "Physiome Remaining Warrant Shares") shall be offered on a pro rata
basis to all other Physiome Preferred Holders (the "Physiome Participating
Purchasers") who fully exercised their respective Funding Warrants, subject to
the terms and conditions set forth below. Each such Physiome Participating
Purchaser's pro rata share shall equal a fraction of the aggregate Physiome
Remaining Warrant Shares, the numerator of which is the number of shares of the
Company's Common Stock issuable upon conversion of the Company's Preferred Stock
held by such Physiome Participating Purchaser, and the denominator of which is
the total number of shares of the Company's Common Stock issuable upon
conversion of the Company's Preferred Stock held by all Physiome Participating
Purchasers. The Company shall give each Physiome Participating Purchaser written
notice (the "Physiome Rights Notice") describing the number of Physiome
Remaining Warrant Shares that such Physiome Participating Purchaser has the
right to purchase under this Section 4(a), together with the applicable Exercise
Price. Each such Physiome Participating Purchaser shall have ten (10) days from
delivery of the Physiome Rights Notice to agree to purchase (i) all or any part
of its pro rata share of such Physiome Remaining Warrant Shares and (ii) all or
any part of the pro rata share of any other Physiome Participating Purchasers to
the extent that such Physiome Participating Purchasers do not elect to purchase
their full pro rata share, upon the general terms specified in the Physiome
Rights Notice, by giving written notice to the Company setting forth the
quantity of Physiome Remaining Warrant Shares to be purchased. If the Physiome
Participating Purchasers who elect to purchase their full pro rata share also
elect to purchase in the aggregate more than 100% of the Physiome Remaining
Warrant Shares, such Physiome Remaining Warrant Shares shall be sold to such
Physiome Participating Purchasers in accordance with their respective pro rata
share. A failure to provide the Company with written notice setting forth the
quantity of Physiome Remaining Warrant Shares to be purchased by any such
Physiome Participating Purchaser in accordance with this Section 4(a) shall be
deemed to be a waiver by such Physiome Participating Purchaser of its right to
purchase any portion of its pro rata portion of such Physiome Remaining Warrant
Shares. At the end of the period specified in the Physiome Rights Notice, if any
Physiome Remaining Warrant Shares remain unallocated (the "Final Physiome
Warrant Shares"), such Final Physiome Warrant Shares shall be offered, in
accordance with the terms set forth in Section 4(c) below, to each Predix
Participating Purchaser who has

                                      -4-
<PAGE>

elected to purchase all or any part of its pro rata share of the Predix
Remaining Warrant Shares (the "Predix Final Purchasers").

      (b) In the event a Predix Preferred Holder (or a Permitted Transferee of
such Holder) fails to exercise this Funding Warrant in full in connection with
each Subsequent Financing prior to the Expiration Date (in addition to the
cancellation of the Holder's future rights under this Transaction Warrant set
forth in Section 1(d)), the right to purchase the Shares underlying this Funding
Warrant (the "Predix Remaining Warrant Shares") shall be offered on a pro rata
basis to all other Predix Preferred Holders (the "Predix Participating
Purchasers") who fully exercised their respective Funding Warrants, subject to
the terms and conditions set forth below. Each such Predix Participating
Purchaser's pro rata share shall equal a fraction of the aggregate Predix
Remaining Warrant Shares, the numerator of which is the number of shares of the
Company's Common Stock plus the number of shares of the Company's Common Stock
issued or issuable upon conversion of the Company's Preferred Stock held by such
Predix Participating Purchaser, and the denominator of which is the total number
of shares of the Company's Common Stock plus the number of shares of the
Company's Common Stock issued or issuable upon conversion of the Company's
Preferred Stock held by all Predix Participating Purchasers. The Company shall
give each Predix Participating Purchaser written notice (the "Predix Rights
Notice") describing the number of Predix Remaining Warrant Shares that such
Predix Participating Purchaser has the right to purchase under this Section
4(b), together with applicable Exercise Price. Each such Predix Participating
Purchaser shall have ten (10) days from delivery of the Predix Rights Notice to
agree to purchase (i) all or any part of its pro rata share of such Predix
Remaining Warrant Shares and (ii) all or any part of the pro rata share of any
other Predix Participating Purchasers to the extent that such Predix
Participating Purchasers do not elect to purchase their full pro rata share,
upon the general terms specified in the Predix Rights Notice, by giving written
notice to the Company setting forth the quantity of Predix Remaining Warrant
Shares to be purchased. If the Predix Participating Purchasers who elect to
purchase their full pro rata share also elect to purchase in the aggregate more
than 100% of the Predix Remaining Warrant Shares, such Predix Remaining Warrant
Shares shall be sold to such Predix Participating Purchasers in accordance with
their respective pro rata share. A failure to provide the Company with written
notice setting forth the quantity of Predix Remaining Warrant Shares to be
purchased by any such Predix Participating Purchaser in accordance with this
Section 4(b) shall be deemed to be a waiver by such Predix Participating
Purchaser of its right to purchase any portion of its pro rata portion of such
Predix Remaining Warrant Shares. At the end of the period specified in the
Predix Rights Notice, if any Predix Remaining Warrant Shares remain unallocated
(the "Final Predix Warrant Shares"), such Final Predix Warrant Shares shall be
offered, in accordance with the terms set forth in Section 4(d) below, to each
Physiome Participating Purchaser who has elected to purchase all or any part of
its pro rata share of the Physiome Remaining Warrant Shares (the "Physiome Final
Purchasers").

      (c) At the end of the ten-day period specified in the Physiome Rights
Notice, the Company shall give each Predix Final Purchaser written notice (the
"Final Predix Rights Notice") describing the number of Final Physiome Warrant
Shares that such Predix Final Purchaser has the right to purchase under this
Section 4(c). Each such Predix Final Purchaser shall have ten (10) days from
delivery of the Final Predix Rights Notice to agree to purchase (i) all or any
part of its pro rata share of such Final Physiome Warrant Shares and (ii) all or
any part of the pro rata share of any other Predix Final Purchasers to the
extent that such Predix Final

                                      -5-
<PAGE>

Purchasers do not elect to purchase their full pro rata share, upon the general
terms specified in the Final Predix Rights Notice, by giving written notice to
the Company setting forth the quantity of Final Physiome Warrant Shares to be
purchased. If the Predix Final Purchasers who elect to purchase their full pro
rata share also elect to purchase in the aggregate more than 100% of the Final
Physiome Warrant Shares, such Final Physiome Warrant Shares shall be sold to
such Predix Final Purchasers in accordance with their respective pro rata share.
A failure to provide the Company with written notice setting forth the quantity
of Final Physiome Warrant Shares to be purchased by any such Predix Final
Purchaser in accordance with this Section 4(c) shall be deemed to be a waiver by
such Predix Final Purchaser of its right to purchase any portion of its pro rata
portion of such Final Physiome Warrant Shares. At the end of the period
specified in the Final Predix Rights Notice, if any Final Physiome Warrant
Shares remain unallocated, the right to purchase such Final Physiome Warrant
Shares shall expire.

      (d) At the end of the ten-day period specified in the Predix Rights
Notice, the Company shall give each Physiome Final Purchaser written notice (the
"Final Physiome Rights Notice") describing the number of Final Predix Warrant
Shares that such Physiome Final Purchaser has the right to purchase under this
Section 4(d). Each such Physiome Final Purchaser shall have ten (10) days from
delivery of the Final Physiome Rights Notice to agree to purchase (i) all or any
part of its pro rata share of such Final Predix Warrant Shares and (ii) all or
any part of the pro rata share of any other Physiome Final Purchasers to the
extent that such Physiome Final Purchasers do not elect to purchase their full
pro rata share, upon the general terms specified in the Final Physiome Rights
Notice, by giving written notice to the Company setting forth the quantity of
Final Predix Warrant Shares to be purchased. If the Physiome Final Purchasers
who elect to purchase their full pro rata share also elect to purchase in the
aggregate more than 100% of the Final Predix Warrant Shares, such Final Predix
Warrant Shares shall be sold to such Physiome Final Purchasers in accordance
with their respective pro rata share. A failure to provide the Company with
written notice setting forth the quantity of Final Predix Warrant Shares to be
purchased by any such Physiome Final Purchaser in accordance with this Section
4(d) shall be deemed to be a waiver by such Physiome Final Purchaser of its
right to purchase any portion of its pro rata portion of such Final Predix
Warrant Shares. At the end of the period specified in the Final Physiome Rights
Notice, if any Final Predix Warrant Shares remain unallocated, the right to
purchase such Final Predix Warrant Shares shall expire.

      (e) The closing of the purchase, if any, of Physiome Remaining Warrant
Shares, Final Physiome Warrant Shares, Predix Remaining Warrant Shares or Final
Predix Warrant Shares, as applicable, by the Holders exercising their rights
hereunder shall take place at the closing of the applicable Subsequent
Financing. At the closing, the Company shall deliver to such Holders
certificates representing all of the Physiome Remaining Warrant Shares, Final
Physiome Warrant Shares, Predix Remaining Warrant Shares or Final Predix Warrant
Shares, as applicable. At the closing, such purchasing Holders shall deliver to
the Company (i) payment for the Physiome Remaining Warrant Shares, Final
Physiome Warrant Shares, Predix Remaining Warrant Shares or Final Predix Warrant
Shares, as applicable, and (ii) at the request of the Company, a duly executed
certificate reasonably satisfactory to the Company containing such
representations and warranties of the purchasing Holders with respect to federal
and state securities laws. The certificates representing the Physiome Remaining
Warrant Shares, Final Physiome Warrant Shares, Predix Remaining Warrant Shares
or Final Predix Warrant Shares, as applicable, may contain a legend stating that
they are issued subject to the registration

                                      -6-
<PAGE>

requirements of the Securities Act of 1933, as amended (the "Securities Act"),
and applicable state securities laws.

      5. Notices.

      (a) All notices, requests, consents, and other communications under this
Funding Warrant shall be in writing and shall be deemed delivered (i) seven
business days after being sent by registered or certified mail, return receipt
requested, postage prepaid or (ii) three business days after being sent via a
reputable nationwide overnight courier service guaranteeing next business day
delivery, in each case to the intended recipient as set forth below:

      If to the Company, at 150 College Road West, Suite 300, Princeton, New
Jersey 08540-6604, Attention: Chief Operating Officer, or at such other address
as may have been furnished in writing by the Company to the Holder, with a copy
to Hale and Dorr LLP, 650 College Road East, Princeton, New Jersey 08540,
Attention: Richard S. Mattessich, Esq.; or

      If to a Holder, at its address set forth on the signature page hereto, or
at such other address as may be furnished in writing by such Holder to the
Company with a copy, in the case of the Predix Preferred Holders, to Mintz,
Levin, Cohn, Ferris, Glovsky and Popeo, P.C., One Financial Center, Boston, MA
02111, Attention : John R. Pomerance, Esq.

      (b) Either party may give any notice, request, consent or other
communication under this Funding Warrant using any other means (including,
without limitation, personal delivery, messenger service, telecopy, first class
mail or electronic mail), but no such notice, request, consent or other
communication shall be deemed to have been duly given unless and until it is
actually received by the party for whom it is intended. Either party may change
the address to which notices, requests, consents or other communications
hereunder are to be delivered by giving the other party notice in the manner set
forth in this Section.

      6. Legends. Each certificate evidencing the Shares issued upon exercise of
this Funding Warrant, or transfer of such Shares (other than a transfer
registered under the Securities Act, or any subsequent transfer of Shares so
registered) shall be stamped or imprinted with a legend substantially in the
following form:

      THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED
      UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR THE
      SECURITIES LAWS OF ANY STATE. THE SECURITIES MAY NOT BE TRANSFERRED EXCEPT
      PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT AND
      APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN APPLICABLE EXEMPTION
      FROM THE REGISTRATION REQUIREMENTS OF SUCH ACT AND SUCH LAWS.

      7. Fractional Shares. No fractional Shares will be issued in connection
with any exercise hereunder. Instead, the Holder shall be permitted to exercise
this Funding Warrant for that number of Shares rounded to the nearest whole
Share.

                                      -7-
<PAGE>

      8. Representations and Warranties by the Holder. The Holder represents and
warrants to the Company as follows:

      (a) This Funding Warrant is being acquired for its own account, for
investment and not with a view to, or for resale in connection with, any
distribution thereof within the meaning of the Securities Act. Upon exercise of
this Funding Warrant, the Holder shall, if so requested by the Company, confirm
in writing, in a form reasonably satisfactory to the Company, that the Shares
issuable upon exercise of this Funding Warrant are being acquired for investment
and not with a view toward distribution or resale that would violate the
Securities Act.

      (b) The Holder understands that the Funding Warrant has not been and the
Shares will not be registered under the Securities Act by reason of their
issuance in a transaction exempt from the registration and prospectus delivery
requirements of the Securities Act pursuant to Section 4(2) thereof, and that
they must be held by the Holder indefinitely, and that the Holder must therefore
bear the economic risk of such investment indefinitely, unless a subsequent
disposition thereof is registered under the Securities Act or is exempted from
such registration.

      (c) The Holder has such knowledge and experience in financial and business
matters that it is capable of evaluating the merits and risks of the purchase of
this Funding Warrant and the Shares purchasable pursuant to the terms of this
Funding Warrant and of protecting its interests in connection therewith.

      (d) The Holder is able to bear the economic risk of the purchase of the
Shares pursuant to the terms of this Funding Warrant.

      (e) The Holder is an "accredited investor" within the meaning of Rule 501
of Regulation D under the Securities Act.

      9. Rights of Stockholders. No Holder, as such, shall be entitled to vote
or receive dividends or be deemed the holder of the Shares or any other
securities of the Company that may at any time be issuable on the exercise
hereof for any purpose, nor shall anything contained herein be construed to
confer upon the Holder, as such, any of the rights of a stockholder of the
Company or any right to vote for the election of directors or upon any matter
submitted to stockholders at any meeting thereof, or to give or withhold consent
to any corporate action (whether upon any recapitalization, issuance of stock,
reclassification of stock, change of par value, consolidation, merger,
conveyance, or otherwise) or to receive notice of meetings, or to receive
dividends or subscription rights or otherwise until this Funding Warrant shall
have been exercised and the Shares purchasable upon the exercise hereof shall
have become issuable, as provided herein.

      10. Expiration of Warrant. Subject to the provisions of Section 1(d) and
Section 4, this Funding Warrant shall expire and shall no longer be exercisable
as of 5:00 p.m., Eastern Time, on July [   ], 2008.

      11. Miscellaneous.

                                      -8-
<PAGE>

      (a) This Funding Warrant shall be governed by and construed for all
purposes under and in accordance with the laws of the State of Delaware without
regard to principles of conflicts of law.

      (b) The headings in this Funding Warrant are for purposes of reference
only, and shall not limit or otherwise affect any of the terms hereof.

      (c) The representations, warranties, covenants and conditions of the
respective parties contained herein or made pursuant to this Funding Warrant
shall survive the execution and delivery of this Funding Warrant.

      (d) The terms of this Funding Warrant shall be binding upon and shall
inure to the benefit of any successors or assigns of the Company and of the
Holder and of the Shares issued or issuable upon the exercise hereof.

      (e) This Funding Warrant and the other documents delivered pursuant hereto
constitute the full and entire understanding and agreement between the parties
with regard to the subjects hereof and thereof.

      (f) The Company shall not, by amendment of its certificate of
incorporation or by-laws, or through any other means, directly or indirectly,
avoid or seek to avoid the observance or performance of any of the terms of this
Funding Warrant and shall at all times in good faith assist in the carrying out
of all such terms and in the taking of all such action as may be necessary or
appropriate in order to protect the rights of the Holder against impairment.

      (g) Upon receipt of evidence reasonably satisfactory to the Company of the
loss, theft, destruction or mutilation of this Funding Warrant and, in the case
of any such loss, theft or destruction, upon delivery of an indemnity agreement
reasonably satisfactory in form and amount to the Company or, in the case of any
such mutilation, upon surrender and cancellation of such Funding Warrant, the
Company, at its expense, will execute and deliver to the Holder, in lieu
thereof, a new Funding Warrant of like date and tenor.

      (h) This Funding Warrant and any provision hereof may be amended, waived
or terminated only by an instrument in writing signed by the Company and the
Holder.

                            [Signature Page Follows]

                                      -9-
<PAGE>

      IN WITNESS WHEREOF, the Company has caused this Funding Warrant to be
signed by its duly authorized officer.

                                           Predix Pharmaceuticals Holdings, Inc.

                                           By __________________________________
                                               Name:
                                               Title:

Acknowledged and Accepted:

[            ]

By ________________________________________
     Name:

     Title:

     Address:

<PAGE>

                                                                       EXHIBIT A

                               NOTICE OF EXERCISE

      TO:  Predix Pharmaceuticals Holdings, Inc.
           Attention: President

      1. The undersigned hereby elects to purchase _______________Subsequent
Financing Securities of Predix Pharmaceuticals Holdings, Inc. pursuant to the
terms of this Funding Warrant, and tenders herewith payment of the purchase
price of such shares in full.

      2. Please issue a certificate or certificates representing said securities
in the name of the undersigned or in such other name as is specified below:

                        _________________________________
                                     (Name)

                        _________________________________

                        _________________________________
                                    (Address)

      3. The undersigned hereby represents and warrants that the aforesaid
securities are being acquired for the account of the undersigned for investment
and not with a view to, or for resale, in connection with the distribution
thereof, and that the undersigned has no present intention of distributing or
reselling such shares and all representations and warranties of the undersigned
set forth in Section 8 of the attached Funding Warrant are true and correct as
of the date hereof.

                                               _________________________________
                                               (Signature and Date)

<PAGE>

                                                                       EXHIBIT B

                               FORM OF ASSIGNMENT

                  (To be executed by the Holder if such Holder
                    desires to transfer the Funding Warrant)

      FOR VALUE RECEIVED ____________________ (the "Transferor") hereby sells,
assigns and transfers unto _______________________________(the "Transferee")

                  (Please print name and address of transferee)

this Funding Warrant, together with all right, title and interest therein, and
does hereby irrevocably constitute and appoint as its Attorney to transfer the
such Funding Warrant on the books of Predix Pharmaceuticals Holdings, Inc., with
full power of substitution. The Transferor has provided a written instrument to
the Company notifying the Company of such transfer and pursuant to which the
Transferee hereunder has agreed in writing to be bound by the terms of the
Funding Warrant dated July [ ], 2003 issued by Predix Pharmaceuticals Holdings,
Inc., a Delaware corporation, a copy of which has been provided to the
Transferee by the Transferor.

Dated:                   Signature _____________________________________________
                         (Signature must conform in all respects to name of
                         Holder as specified on the face of the Funding Warrant)

                         _______________________________________________________
                         (Insert Social Security or other Identifying Number of
                         Holder)

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