Document:

EX-10.6

 Exhibit 10.6 

EXECUTIVE EMPLOYMENT AGREEMENT 

This EXECUTIVE EMPLOYMENT AGREEMENT (the “Agreement”), is made and entered into effective as of February 1, 2015 (the
“Effective Date”), by and between G1 Therapeutics, Inc., a Delaware corporation (the “Company”), and Gregory Mossinghoff (“Employee”). 

1. EMPLOYMENT; TERMINATION OF CONSULTING RELATIONSHIP; DUTIES. The Company agrees to employ Employee as its Chief Business Officer, and
Employee agrees to accept such employment upon the terms and conditions hereinafter set forth. In connection with Employee’s employment with the Company, the parties mutually agree that the prior Consulting Agreement between them is terminated
by mutual consent as of the Effective Date. Employee will perform such services for the Company as are customarily associated with such position and as may otherwise be assigned to the Employee from time to time by the Company’s Chief Executive
Officer or his designee. Employee will devote his full business time and attention to the business and affairs of the Company, and will perform his duties diligently and to the best of his ability, in compliance with the Company’s policies and
procedures and the laws and regulations that apply to the Company’s business. Notwithstanding the foregoing, Employee will be permitted during the term of this Agreement, subject to the approval of the Company’s CEO as described below, to
consult on an ad hoc basis with those clients of the Employee which pre-existed the Effective Date of this Agreement. In either case, Employee will disclose to the CEO nature and time commitment associated with any consulting activity or board
service so that the CEO can determine that the position (i) is not competitive with the Business of the Company as described in Section 8(a) below, and (ii) will not interfere with Employee’s duties to the Company hereunder. The
CEO’s approval will not be unreasonably withheld. 
 2. TERM; TERMINATION. Employee’s employment under this Agreement will
commence as of the Effective Date and will continue until terminated by either party. Employee’s employment with the Company is at-will, and either party can terminate the employment relationship and/or this Agreement at any time, for any or no
cause or reason, and with or without prior notice. Upon termination of Employee’s employment by either party for any reason, Employee will resign his position(s), if any, as an officer or director of the Company, as a member of the
Company’s Board of Directors (the “Board”) and any Board committees, as well as any other positions he may hold with or for the benefit of the Company and/or its affiliates. 

3. COMPENSATION. As compensation for the services to be rendered by Employee under this Agreement, the Company will provide the
following compensation and benefits during Employee’s employment hereunder. 
 (a) BASE SALARY. The Company will pay Employee a
base salary (the “Base Salary”) at an annual rate of Two Hundred Forty Thousand Dollars ($240,000.00), payable in equal installments in accordance with the Company’s customary payroll practices as 

 
in effect from time to time. The Base Salary may be reviewed from time to time by theCompany and may be increased in the sole discretion of the Company. The Base Salary may also be decreased in
connection with any Company-wide decrease in executive compensation. 
 (b) ANNUAL BONUS. Employee will be eligible to receive an
annual calendar year bonus based upon Employee’s and the Company’s achievement of certain individual and Company goals that will be set for Employee by the Board or its designee (the “Annual Bonus”). The amount of the
target Annual Bonus will be equal to twenty percent (20%) of Employee’s then-current Base Salary as of the date of the payment. One half of the Annual Bonus awarded for any given year will be paid in cash, and the other half of the Annual
Bonus awarded for any given year will be paid, in the sole discretion of the Company, either in cash or in the form of options to acquire shares of the Company’s common stock (or other equity interests as selected by the Company), in any case
subject to the terms and conditions of the Company’s 2011 Equity Incentive Plan. For any grant of stock options or equity issued pursuant to this Section 3(b), the number of options or other equity interests allocated to the non-cash
portion of the Annual Bonus will be determined by the Company in its sole discretion. The Board will have the sole discretion to set the applicable individual and Company goals, to determine whether the goals have been met, and to determine the
amount of the Annual Bonus. The Annual Bonus for any given year will be paid between January 1 and January 31 in the year immediately following the year in which the Annual Bonus, if any, is earned. Employee must be employed by the Company
on December 31 of the bonus year in order to receive the Annual Bonus for that year. 
 (c) STOCK OPTIONS. Employee has
previously been granted a non-qualified stock option to purchase 171,900 shares of the Company’s common stock (the “Prior Option”) pursuant to the terms of the Company’s 2011 Equity Incentive Plan (the “Plan”)
and that certain Stock Option Agreement between Company and Employee effective as of July 11, 2014. The Prior Option remains subject to the terms of the Plan and the July 11, 2014 Stock Option Agreement. Subject to approval by the
Board, Employee will be granted, effective as of date of Board approval, an incentive stock option to purchase a number of shares of the Company’s common stock, which taken together with the shares covered by the Prior Option, will represent
1.40% of the Company’s total outstanding shares of common stock, determined on a fully-diluted, as-converted into common stock basis after the conclusion of the first tranche of the Company’s Series B Preferred Stock Financing. (the
“New Option”). The New Option will be granted pursuant to and subject to the terms and conditions of the Plan and will be further subject to the terms of a stock option agreement as approved by the Board setting forth the exercise
price, vesting conditions, and other restrictions. One fourth of the total number of the shares covered by the New Option will vest on the first anniversary of the date hereof, and one forty eighth (1/48th) of the total number of the shares
covered by the New Option will vest each month over the following thirty six (36) months thereafter, so long as Employee remains employed by the Company through each such vesting date. Fifty Percent (50%) of any unvested portion of the New
Option will immediately vest upon the consummation of a Change in Control (as defined below) and any remaining unvested portion of the New Option will immediately vest if Employee’s employment is terminated by the Company without Cause (as
defined below) or Employee resigns with Good Reason (as defined below) within ninety (90) days following a Change in Control. As used herein, “Change in Control” means (i) the Company’s merger or consolidation with or
into another entity such that 

 
the stockholders of the Company prior to such transaction do not or are not expected to own a majority of the voting stock of the surviving entity, (ii) the sale or other disposition of all
or substantially all of the assets of the Company, (iii) the sale or other disposition of greater than 50% of the then-outstanding voting stock of the Company by the holders thereof to one or more persons or entities who are not then
stockholders of the Company. 
 (d) VACATION. Employee will be eligible to accrue up to four (4) weeks of paid time off per
calendar year (prorated for any partial years), which paid time off must be used in accordance with, and is otherwise subject to, the Company’s policies and procedures. 

(e) BENEFITS. Employee will (subject to applicable eligibility requirements) receive such other benefits as are provided from time to
time to other similarly-situated employees of the Company pursuant to the Company’s policies and procedures as they may be instituted from time to time. All such benefits are subject to the provisions of their respective plan documents in
accordance with their terms. Employee acknowledges and agrees that the Company has the unilateral right to amend, modify or terminate its employee benefit plans or policies to the maximum extent allowed by law. 

(f) EXPENSE REIMBURSEMENT. The Company will reimburse Employee for all reasonable business expenses incurred by Employee in connection
with the performance of his duties hereunder, subject to Employee’s compliance with the Company’s reimbursement policies in effect from time to time. 

(g) WITHHOLDINGS. The Company will withhold from any amounts payable under this Agreement, such federal, state and local taxes, as the
Company reasonably determines are required to be withheld pursuant to applicable law. 
 4. EFFECT OF TERMINATION. 

(a) GENERALLY. When Employee’s employment with the Company is terminated for any reason, Employee, or his estate, as the case may
be, will be entitled to receive the compensation and benefits earned through the effective date of termination, along with reimbursement for any approved business expenses that Employee has timely submitted for reimbursement in accordance with the
Company’s expense reimbursement policy or practice. 
 (b) SEPARATION BENEFITS UPON CERTAIN TERMINATIONS. If the Company
terminates Employee’s employment without Cause (as defined below), or if Employee resigns his employment for Good Reason (as defined below), then conditioned upon Employee executing a Release (as defined below) following such termination,
Employee will be entitled to receive the continued payment of Employee’s then-current Base Salary for a period of six (6) months after termination (the “Separation Benefits”). The Separation Benefits are conditioned upon
Employee executing a release of claims in a form satisfactory to the Company (the “Release”) within the time specified therein, which Release is not revoked within any time period allowed for revocation under applicable law. The
Salary Continuation will be payable to Employee over time in accordance with the Company’s payroll practices and procedures beginning on the sixtieth (60th) day following the termination of Employee’s employment with

 
the Company, provided that the Company, in its sole discretion, may begin the payments earlier. For avoidance of doubt, the termination of Employee’s employment as a result of his death or
disability (meaning the inability of Employee, due to the condition of his physical, mental or emotional health, effectively to perform the essential functions of his job with or without reasonable accommodation for a continuous period of more than
90 days or for 90 days in any period of 180 consecutive days, as determined by the Board in its sole discretion in consultation with a physician retained by the Company) will not constitute a termination without Cause triggering the rights described
in this Section 4(b). 
 (c) CAUSE. For purposes of this Agreement, “Cause” means: (i) Employee’s
fraud, embezzlement or misappropriation with respect to the Company; (ii) Employee’s material breach of fiduciary duties to the Company; (iii) Employee’s willful or negligent misconduct that has or may reasonably be expected to
have a material adverse effect on the property, business, or reputation of the Company; (iv) Employee’s material breach of this Agreement; (v) Employee’s willful failure or refusal to perform his material duties under this
Agreement or failure to follow any specific lawful instructions of the CEO; (vi) Employee’s conviction or plea of nolo contendere in respect of a felony or of a misdemeanor involving moral turpitude; (vii) Employee’s alcohol or
substance abuse which has a material adverse effect on Employee’s ability to perform his duties under this Agreement; or (viii) Employee’s engagement in a form of discrimination or harassment prohibited by law (including, without
limitation, discrimination or harassment based on race, color, religion, sex, national origin, age or disability). In the event that the Company concludes that Employee has engaged in acts constituting in Cause as defined in clause (iii), (iv), (v),
or (vii) above, prior to terminating this Agreement for Cause the Company will provide Employee with at least fifteen (15) days’ advance written notice of the specific circumstances constituting such Cause, and an opportunity to
correct such circumstances. 
 (d) GOOD REASON. In order for Employee to resign for Good Reason, Employee must provide written notice
to the Company of the existence of the Good Reason condition within thirty (30) days of the initial existence of such Good Reason condition. Upon receipt of such notice, the Company will have fifteen (15) days during which it may attempt
to remedy the Good Reason condition and not be required to provide for the benefits described in Section 4(b) above as a result of such proposed resignation if successfully remedied. If the Good Reason condition is not remedied within such
fifteen (15) day period, Employee may resign based on the Good Reason condition specified in the notice effective no later than thirty (30) days following the expiration of the fifteen (15) day cure period. For purposes of this
Agreement, “Good Reason” means the occurrence of any of the following events without Employee’s consent: (i) a material reduction of Employee’s Base Salary not generally applicable to other executive-level employees
of the Company, (ii) a material diminution of the Employee’s authority, duties, or responsibilities, (iii) a relocation of Employee’s primary workplace to a location that is more than fifty (50) miles from the location of
Employee’s primary workplace as of the date hereof, or (iv) the Company’s material breach of this Agreement. 
 (e)
APPLICATION OF INTERNAL REVENUE CODE SECTION 409A. Notwithstanding anything to the contrary set forth herein, any payments and benefits provided 

 
under this Section 4 that constitute “deferred compensation” within the meaning of Section 409A of the Internal Revenue Code and the regulations and other guidance thereunder
and any state law of similar effect (collectively “Section 409A”) will not commence in connection with Employee’s termination of employment unless and until Employee has also incurred a “separation from service” (as
such term is defined in Treasury Regulation Section 1.409A-1(h) (a “Separation From Service”), unless the Company reasonably determines that such amounts may be provided to Employee without causing Employee to incur the
additional 20% tax under Section 409A. The parties intend that each installment of the Separation Benefits payments provided for in this Agreement is a separate “payment” for purposes of Treasury Regulation
Section 1.409A-2(b)(2)(i). For the avoidance of doubt, the parties intend that payments of the Separation Benefits set forth in this Agreement satisfy, to the greatest extent possible, the exemptions from the application of Section 409A
provided under Treasury Regulation Sections 1.409A-1(b)(4), 1.409A-1(b)(5) and 1.409A-1(b)(9). However, if the Company determines that the Separation Benefits constitute “deferred compensation” under Section 409A and Employee is, on
the termination of service, a “specified employee” of the Company or any successor entity thereto, as such term is defined in Section 409A, then, solely to the extent necessary to avoid the incurrence of the adverse personal tax
consequences under Section 409A, the timing of the Separation Benefits payments will be delayed until the earlier to occur of: (i) the date that is six months and one day after Employee’s Separation From Service, or (ii) the date
of Employee’s death (such applicable date, the “Specified Employee Initial Payment Date”), and the Company (or the successor entity thereto, as applicable) will (A) pay to Employee a lump sum amount equal to the sum of the
Separation Benefits payments that Employee would otherwise have received through the Specified Employee Initial Payment Date if the commencement of the payment of the Separation Benefits had not been so delayed pursuant to this Section, and
(B) commence paying the balance of the Separation Benefits in accordance with the applicable payment schedules set forth in this Agreement. 

(f) NO FURTHER OBLIGATIONS. Except as expressly provided above or as otherwise required by law, the Company will have no obligations to
Employee in the event of the termination of this Agreement for any reason. 
 5. EMPLOYEE REPRESENTATIONS. Employee represents and
warrants that he is not obligated or restricted under any agreement (including any non-competition or confidentiality agreement), judgment, decree, order or other restraint of any kind that could impair Employee’s ability to perform the duties
and obligations required of Employee hereunder. Employee further agrees that he will not divulge to the Company any confidential information and/or trade secrets belonging to others, including Employee’s former employers, nor will the Company
seek to elicit from Employee such information. Consistent with the foregoing, Employee will not provide to the Company, and the Company will not request, any documents or copies of documents containing such information. 

 6. CONFIDENTIALITY. 

(a) Employee acknowledges that the Company will give Employee access to certain highly-sensitive, confidential, and proprietary information
belonging to the Company or third parties who may have furnished such information under obligations of confidentiality, relating to and used in the Company’s business (collectively, “Confidential Information”). Employee
acknowledges that, unless otherwise available to the public, Confidential Information includes, but is not limited to, the following categories of Company related confidential or proprietary information and material, whether in electronic, print, or
other form, including all copies, notes, or other reproductions or replicas thereof: financial statements and information; budgets, forecasts, and projections; business and strategic plans; marketing, sales, and distribution strategies; research and
development projects; records relating to any intellectual property developed by, owned by, controlled, or maintained by the Company; information related to the Company’s inventions, research, products, designs, methods, formulae, techniques,
systems, processes; customer lists; non-public information relating to the Company’s customers, suppliers, distributors, or investors; the specific terms of the Company’s agreements or arrangements, whether oral or written, with any
customer, supplier, vendor, or contractor with which the Company may be associated from time to time; and any and all information relating to the operation of the Company’s business which the Company may from time to time designate as
confidential or proprietary or that Employee reasonably knows should be, or has been, treated by the Company as confidential or proprietary. Confidential Information encompasses all formats in which information is preserved, whether electronic,
print, or any other form, including all originals, copies, notes, or other reproductions or replicas thereof. 
 (b) Confidential
Information does not include any information that: (i) at the time of disclosure is generally known to, or readily ascertainable by, the public; (ii) becomes known to the public through no fault of Employee or other violation of this
Agreement; or (iii) is disclosed to Employee by a third party under no obligation to maintain the confidentiality of the information. 

(c) Employee acknowledges that the Confidential Information is owned or licensed by the Company; is unique, valuable, proprietary and
confidential; and derives independent actual or potential commercial value from not being generally known or available to the public. Employee hereby relinquishes, and agrees that he will not at any time claim, any right, title or interest of any
kind in or to any Confidential Information, 
 (d) During and after his employment with the Company, Employee will hold in trust and
confidence all Confidential Information, and will not disclose any Confidential Information to any person or entity, except in the course of performing duties assigned by the Company or as authorized in writing by the Company. Employee further
agrees that during and after his employment with the Company, Employee will not use any Confidential Information for the benefit of any third party, except in the course of performing duties assigned by the Company or as authorized in writing by the
Company. 
 (e) The restrictions in Section 6(d) above will not apply to any information to the extent that Employee is required to
disclose such information by law, provided that the Employee (i) notifies the Company of the existence and terms of such obligation, (ii) gives the Company a reasonable opportunity to seek a protective or similar order to prevent or limit
such disclosure, and (iii) only discloses that information actually required to be disclosed. 

 (f) Any trade secrets of the Company will be entitled to all of the protections and benefits
under the North Carolina Trade Secrets Protection Act, N.C. Gen. Stat. § 66-152 et seq., and any other applicable law. If any information that the Company deems to be a trade secret is found by a court of competent jurisdiction not to be
a trade secret, such information will, nevertheless, be considered Confidential Information for purposes of this Agreement. 
 (g) Upon
request during employment and immediately at the termination of this Agreement, Employee will return to the Company all Confidential Information in any form (including all copies and reproductions thereof) and all other property whatsoever of the
Company in his possession or under his control. If requested by the Company, Employee will certify in writing that all such materials have been returned to the Company. Employee also expressly agrees that immediately upon the termination of his
employment with the Company for any reason, Employee will cease using any secure website, web portals, e-mail system, or phone system or voicemail service provided by the Company for the use of its employees. 

7. INTELLECTUAL PROPERTY. 

(a) Employee agrees that all developments or inventions (including without limitation any and all software programs (source and object code),
algorithms and applications, concepts, designs, discoveries, improvements, processes, techniques, know-how and data) that result from work performed by Employee for the Company, whether or not patentable or registrable under copyright or similar
statutes or subject to analogous protection (“Inventions”), will be the sole and exclusive property of the Company or its nominees, and Employee will and hereby does assign to the Company all rights in and to such Inventions upon the
creation of any such Invention, including, without limitation: (i) patents, patent applications and patent rights throughout the world; (ii) rights associated with works of authorship throughout the world, including copyrights, copyright
applications, copyright registrations, mask work rights, mask work applications and mask work registrations; (iii) rights relating to the protection of trade secrets and confidential information throughout the world; (iv) rights analogous
to those set forth herein and any other proprietary rights relating to intangible property; and (v) divisions, continuations, renewals, reissues and extensions .of the foregoing (as applicable), now existing or hereafter filed, issued or
acquired (collectively, the “IP Rights”). 
 (b) For avoidance of doubt, if any Inventions fall within the definition of
“work made for hire”, as such term is defined in 17 U.S.C. § 101, such Inventions will be considered “work made for hire” and the copyright of such Inventions will be owned solely and exclusively by the Company. If any
Inventions does not fall within such definition of “work made for hire”, then Employee’s right, title and interest in and to such Inventions will be assigned to the Company pursuant to Section 7(a) above. 

(c) The Company and its nominees will have the right to use and/or to apply for statutory or common law protections for such Inventions in any
and all countries. Employee further agrees, at the Company’s expense, to: (i) reasonably assist the Company in obtaining and from time to time enforcing such IP Rights relating to Inventions, and (ii) execute and deliver to the
Company or its nominee upon reasonable request all such documents as the Company or its 

 
nominee may reasonably determine are necessary or appropriate to effect the purposes of this Section 7, including assignments of inventions. Such documents may be necessary to: (1) vest
in the Company or its nominee clear and marketable title in and to Inventions; (2) apply for, prosecute and obtain patents, copyrights, mask works rights and other rights and protections relating to Inventions; or (3) enforce patents,
copyrights, mask works rights and other rights and protections relating to Inventions. Employee’s obligations pursuant to this Section 7 will continue beyond the termination of Employee’s employment with the Company. If the Company is
unable for any reason to secure Employee’s signature to any lawful and necessary document required to apply for or execute any patent, trademark, copyright or other applications with respect to any Inventions (including renewals, extensions,
continuations, divisions or continuations in part thereof), Employee hereby irrevocably designates and appoints the Company and its then current Chief Executive Officer as Employee’s agent and attorney-in-fact to act for and in behalf and
instead of Employee, to execute and file any such application and to do all other lawfully permitted acts to further the prosecution and issuance of patents, trademarks, copyrights or other rights thereon with the same legal force and effect as if
executed by Employee. In the event the Company utilizes the power of attorney set forth in the preceding sentence, the Company will provide Employee with written notice of the terms and circumstances of such utilization within thirty (30) days
following such utilization. 
 (d) The obligations of Employee under Section 7(a) will not apply to any Invention that Employee
developed entirely on his own time without using the Company’s equipment, supplies, facility or trade secret information, except for those Inventions that (i) relate to the Company’s business or actual or demonstrably anticipated
research or development, or (ii) result from any work performed by Employee for Company. Employee will bear the burden of proof in establishing the applicability of this subsection to a particular circumstance. 

8. NON-COMPETITION AND NON-SOLICITATION. 

(a) DEFINITIONS. As used in this Agreement, the following terms have the meanings given to such terms below. 

(i) “Business” means the discovery, development and commercialization of pharmaceutical products that are CDK4/6 inhibitors
for chemoprotection, renalprotection, or radioprotection activity, or also for anti-neoplastic activity. 
 (ii)
“Customer” means any person or entity who, at the time of, or in the twelve (12) months prior to the termination of Employee’s employment with the Company for any reason, was an actual customer of the Company with whom the
Employee had dealings in the course of Employee’s employment with the Company, or about whom Employee learned or received Confidential Information in the course of Employee’s employment with Company. 

(iii) “Company Employee” means any person who is or was an employee or independent contractor of the Company at the time of,
or during the twelve (12) month period prior to, the termination of Employee’s employment with the Company for any reason. 

 (iv) “Restricted Period” means the period commencing on the date of termination
of Employee’s employment with the Company for any reason and ending twelve (12) months after such date, provided, however, that this period will be tolled and will not run during any time Employee is in violation of this Section 8, it
being the intent of the parties that the Restricted Period will be extended for any period of time in which Employee is in violation of this Section 8 so as to provide the Company with the full benefit of the twelve-month period. 

(v) “Restricted Territory” means the (A) the United States of America; (B) the State of North Carolina; and
(C) any state, province, or similar geographic subdivision to which Employee directed or in which Employee performed employment-related activities on behalf of the Company at the time of, or during the twelve (12) month period prior to,
the termination of Employee’s employment with the Company for any reason. 
 (b) NON-COMPETITION. During Employee’s
employment with the Company, Employee will not, on Employee’s own behalf or on behalf of any other person, engage in any business competitive with or adverse to that of the Company. In addition, Employee will not hold a position based in or
with responsibility for all or part of the Restricted Territory, with any person or entity engaging in the Business, whether as employee, consultant, or otherwise, in which Employee will have duties, or will perform or be expected to perform
services for such person or entity, that is or are the same as or substantially similar to the position held by Employee or those duties or services actually performed by Employee for the Company within the twelve (12) month period immediately
preceding the termination of Employee’s employment with the Company, or in which Employee will use or disclose or be reasonably expected to use or disclose any Confidential Information of the Company for the purpose of providing, or attempting
to provide, such person or entity with a competitive advantage with respect to the Business. Notwithstanding the foregoing, Employee may, as a passive investor, own capital stock of a publicly held corporation engaging in or affiliated with an
entity engaging in the Business, so long as the Employee’s ownership is not in excess of five percent (5%) of the total outstanding capital stock of such corporation. 

(c) NON-SOLICITATION OF COMPANY EMPLOYEES. Employee agrees that during Employee’s employment and during the Restricted Period,
Employee will not, directly or indirectly, solicit, induce, or encourage any Company Employee to terminate his or her employment with or engagement by the Company. 

(d) NON-SOLICITATION OF CUSTOMERS. Employee agrees that during Employee’s employment and during the Restricted Period, Employee
will not, directly or indirectly, solicit, take away or otherwise interfere with any Customer, supplier or vendor of the Company on Employee’s own behalf or on behalf of any other party. 

(e) ACKNOWLEDGEMENT. Employee acknowledges and agrees that (i) the restrictive covenants in this Agreement are essential elements
of Employee’s employment by the Company and are reasonable given Employee’s access to the Company’s confidential information and the substantial knowledge and goodwill Employee will acquire with respect to the business of the Company
as a result of Employee’s employment with the Company; (ii) the restrictive covenants contained in this Agreement are reasonable in time, territory, scope, and all other respects; and (iii) enforcement of the restrictions contained
herein will not deprive the Employee 

 
of the ability to earn a reasonable living. The Parties further agree that if any portion of this Section 8 is found to be invalid or unenforceable by a court of competent jurisdiction
because its duration, territory, or other restrictions are deemed to be invalid or unreasonable in scope, the invalid or unreasonable terms will be replaced by terms that are valid and enforceable and that come closest to expressing the intention of
such invalid or unenforceable terms. 
 9. ENFORCEMENT. Employee acknowledges and agrees that the Company will suffer irreparable
harm in the event that Employee breaches any of Employee’s obligations under Sections 6, 7, or 8 of this Agreement and that monetary damages would be inadequate to compensate the Company for such breach. Accordingly, Employee agrees that, in
the event of a breach by Employee of any of Employee’s obligations under Sections 6, 7, or 8 of this Agreement, the Company will be entitled to obtain from any court of competent jurisdiction preliminary and permanent injunctive relief, and
expedited discovery for the purpose of seeking relief, in order to prevent or to restrain any such breach. The Company will be entitled to recover its costs incurred in connection with any action to enforce Sections 6, 7, or 8 of this Agreement,
including reasonable attorneys’ fees and expenses, to the maximum extent permitted by law. 
 10. NOTICES. Any notice required
to be given hereunder will be sufficient if in writing and hand delivered or sent by mail, return receipt requested, postage prepaid, in the case of Employee, to his address shown on the Company’s records, and in the case of the Company, to 79
T.W. Alexander Drive, 4401 Research Commons, Suite 105, Research Triangle Park, NC 27709, or to such other addresses as either party shall specify to the other. 

11. AMENDMENT; WAIVER. No amendment of any provision of this Agreement will be valid unless the amendment is in writing and signed by
the Company and Employee. No waiver of any provision of this Agreement will be valid unless the waiver is in writing and signed by the waiving party. The failure of a party at any time to require performance of any provision of this Agreement will
not affect such party’s rights at a later time to enforce such provision. No waiver by a party of any breach of this Agreement will be deemed to extend to any other breach hereunder or affect in any way any rights arising by virtue of any other
breach. 
 12. GOVERNING LAW; VENUE. This Agreement will be governed by and construed in accordance with the laws of the State of
North Carolina, without regard to that body of law known as choice of law. The parties agree that any litigation arising out of or related to this Agreement or Employee’s employment by the Company will be brought exclusively in any state or
federal court in Durham County, North Carolina. Each party (i) consents to the personal jurisdiction of said courts, (ii) waives any venue or inconvenient forum defense to any proceeding maintained in such courts, and (iii) agrees not
to bring any proceeding arising out of or relating to this Agreement or Employee’s employment by the Company in any other court. 
 13.
BENEFIT. This Agreement will be binding upon and will inure to the benefit of each of the parties hereto, and to their respective heirs, representatives, successors and permitted assigns. Employee may not assign any of his rights or delegate
any of his duties under this Agreement. 

 14. ENTIRE AGREEMENT. This Agreement contains the entire agreement and understanding by
and between the Company and Employee with respect to the subject matter hereof, and any representations, promises, agreements or understandings, written or oral, not herein contained will be of no force or effect. 

15. CAPTIONS; RULE OF CONSTRUCTION. The captions in this Agreement are for convenience only and in no way define, bind or describe the
scope or intent of this Agreement. The terms and provisions of this Agreement will not be construed against the drafter or drafters hereof. All parties hereto agree that the language of this Agreement will be construed as a whole according to its
fair meaning and not strictly for or against any of the parties hereto. 
 16. COUNTERPARTS. This Agreement may be executed in one or
more counterparts, each of which will be deemed an original but all of which together will constitute one and the same agreement. Facsimile or PDF reproductions of original signatures will be deemed binding for the purpose of the execution of this
Agreement. 
 17. SEVERABILITY. Each provision of this Agreement is severable from every other provision of this Agreement. Any
provision of this Agreement that is determined by any court of competent jurisdiction to be invalid or unenforceable will not affect the validity or enforceability of any other provision. Any provision of this Agreement held invalid or unenforceable
only in part or degree will remain in full force and effect to the extent not held invalid or unenforceable. 
 18. SURVIVAL. The
terms of Sections 4 through 18 will survive the termination or expiration of this Agreement for any reason. 
 IN WITNESS WHEREOF, the
parties have executed this Agreement effective as of the Effective Date. 
  

			
	G1 THERAPEUTICS, INC.:
		
	By:	 	 /s/ Mark A. Velleca

		 	Mark A. Velleca
		 	Chief Executive Officer
	
	EMPLOYEE:
	
	 /s/ Gregory Mossinghoff

	Gregory MossinghoffEX-10.7

 Exhibit 10.7 

CONSULTING AGREEMENT 

THIS CONSULTING AGREEMENT (this “Agreement”) is made and entered into as of June 3, 2014 (the “Effective
Date”), by and between G1 Therapeutics, Inc., a Delaware corporation (the “Company”) and Gregory Mossinghoff (the “Consultant”). 

WITNESSETH: 
 WHEREAS, the
Company desires to engage Consultant to provide certain advisory services on an independent contractor basis as outlined below, and Consultant wishes to provide such services to Company; and 

WHEREAS, the Company and Consultant desire to establish and document the terms and conditions of such consulting relationship between them.

 NOW, THEREFORE, in consideration of the mutual promises and obligations of the parties set forth herein and for other good and valuable
consideration, the receipt and legal sufficiency of which are hereby acknowledged, the parties agree as follows: 
 1. Appointment of Consultant;
Services. Company appoints Consultant and Consultant hereby accepts appointment as an independent contractor to perform consulting and advisory services in the areas of financial management, strategic planning, and business development as may be
requested by the Company (the “Services”). 
 2. Term; Termination. This Agreement will be effective as of the Effective Date
and will continue in effect for a period of one (1) year unless sooner terminated as provided below (the “Term”). Following the initial term of this Agreement, the parties may agree in writing to extend the Term or may enter
into a new agreement if desired. This Agreement may be terminated by either party upon sixty (60) days’ written notice to the other party (or sooner upon the parties’ mutual written consent). This Agreement may also be terminated by
Company immediately upon written notice if Consultant is unable, refuses or fails to perform the Services in a timely and professional manner, subject to the allotted time commitment, or by either party based on the other party’s material
failure to comply with the obligations set forth in this Agreement unless cured within ten (10) days of receipt of written notice. Upon termination of this Agreement for any reason, the Company will pay all unpaid consulting fees (as described
below) through the effective date of termination. 
 3. Duties of Consultant. During the Term, Consultant will be expected to devote a
reasonable amount of time to the provision of the Services. Consultant and Company anticipate that Consultant’s services for the Company will require at least three (3) days per week of his regular working time. Consultant agrees to
faithfully, diligently, competently, and to the best of his ability within the allotted time commitment perform the Services, provided that Consultant will at all times retain sole and absolute discretion and judgment in the manner and means of
carrying out the Services. Consultant will be responsible for his expenses incurred in connection with the performance of the services described herein, including, without limitation, the costs and expenses of any insurance, office space, and
supplies, as well as any applicable taxes, withholdings, contributions, fees or charges levied or required by any governmental entity as a result of Consultant’s performance of the Services, provided, however, that if Consultant is 

 
required to travel in order to perform the Services, the Company will reimburse Consultant for such reasonable travel expenses incurred by Consultant provided that such expenses are approved in
advance by the Chief Executive Officer of the Company or his designee, and provided further that Consultant presents a detailed and itemized account of such expenses along with proper documentation as the Company may request. Consultant will obtain
and maintain all licenses, permits and approvals necessary to perform the Services. 
 4. Services for Others. Consultant will be free to perform
consulting services for other persons and entities during the Term, provided that performance of such services does not interfere with Consultant’s performance of the Services under this Agreement, and provided further that Consultant will
comply with Sections 10 and 11 of this Agreement with respect to his services for or on behalf of other persons and entities. If, during the Term, Consultant undertakes to provide consulting services for any third party engaged in the Business of
the Company (as defined below), Consultant will immediately provide notice to the Company of such engagement. Such notice must identify the party for whom Consultant has been engaged and provide a description of the services Consultant will provide.
As used herein, the “Business of the Company” means the discovery, development and commercialization of pharmaceutical products that are CDK4/6 inhibitors for chemoprotection, renalprotection, or radioprotection activity, or also
for anti-neoplastic activity. 
 5. Compensation of Consultant. As compensation for the performance of the Services, the Company will pay
Consultant a consulting fee of Ten Thousand Dollars ($10,000) per month throughout the Term, prorated for any partial months. Consultant will submit a monthly invoice to the Company describing the work performed in the month, and the Company will
pay the monthly fee within thirty (30) days following Consultant’s submission of the invoice. 
 6. Stock Options. Subject to
approval by the Company’s Board of Directors, the Company will grant Consultant non-qualified stock options to purchase 171,900 shares of the Company’s common stock (currently representing 0.7% of the Company’s total outstanding
shares of common stock, determined on a fully-diluted, as-converted into common stock basis) (the “Options”). The Options will vest in four (4) equal installments at the conclusion of each three-month anniversary of the date
hereof. The Options will be granted pursuant and subject to the terms and conditions of the Company’s 2011 Equity Incentive Plan and any separate stock option agreement between the Company and Consultant. 

7. Independent Contractor Status of Consultant. 

(a) Consultant’s legal status is an independent contractor of Company. Nothing in this Agreement makes Consultant the agent,
partner, joint venturer, employee or legal representative of Company for any purpose whatsoever; nor shall Consultant hold himself out as such. Consultant will have no authority to bind Company in any manner or for any purpose. 

(b) Consultant (and any employees or agents of Consultant) will not be employees of Company for any purpose, including for purposes of
the Fair Labor Standards Act’s minimum wage and overtime provisions, nor any other provision of federal, state, or local law applicable to employees. Further, Consultant understands and agrees that he (and any employees or agents of Consultant)
will not be entitled to any employment benefits that may be made available by the  

  
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Company to its employees, including but not limited to vacation pay, sick leave, retirement benefits, social security, workers’ compensation, health or disability benefits, and unemployment
insurance benefits. 
 (c) Consultant acknowledges that he has not relied on any statements or representations by the Company or its
attorneys with respect to the tax treatment of any compensation due under this Agreement. Consultant understands that the Company will not be responsible for withholding or paying any federal or state income, social security or other taxes in
connection with any compensation paid under this Agreement, and Consultant agrees that he is solely responsible for any such tax payments. 
 8.
Representations. Consultant hereby represents and warrants to Company that (a) Consultant is free to enter into this Agreement with Company and to perform the Services described herein; (b) the execution of this Agreement and the
performance of the Services by Consultant will not result in the breach of any express or implied, oral or written, contract or agreement, to which Consultant is bound (including, without limitation, any non-competition agreement with a current or
prior employer); and (c) the execution of this Agreement and the performance of the Services will not at any time interfere with or violate any third party rights (including, without limitation, the use, disclosure, misappropriation, or
infringement of any confidential information, proprietary rights or intellectual property belonging to any other person or entity). 
 9.
Indemnification. Consultant agrees to indemnify and hold Company harmless from and against any and all third party liabilities, claims, causes of action, losses, costs, fees (including, without limitation, attorneys’ fees), expenses,
damages and penalties arising out of or relating to the acts or omissions of Consultant or its agents in performing Consultant’s obligations under this Agreement (including, without limitation, any negligence or intentional misconduct in
performing the Services, any breach of any representation or warranty contained in this Agreement, or any breach of any other provision of this Agreement by Consultant). 

10. Ownership of Intellectual Property. 

(a) Consultant will immediately and fully disclose in writing to the Company all intellectual property and other proprietary
information, including without limitation, all inventions, methods, processes, innovations, discoveries, developments, ideas, technologies, computer code and programs, macros, trade secrets, know-how, formulae, designs, patterns, marks, names,
improvements, industrial designs, mask works, works of authorship, technical materials relating to the business of the Company conceived or developed by the Consultant during the Term (collectively, “Intellectual Property”) whether
or not any such Intellectual Property is patentable, copyrightable, or otherwise protectable. Notwithstanding the foregoing, this Agreement shall not be construed to apply to, and shall not create any assignment of, any Intellectual Property of
Consultant that Consultant developed entirely on his own time without using the Company’s equipment, facilities, or trade secret information, except for Intellectual Property that results from any work performed by the Consultant for the
Company. 
 (b) Consultant does hereby, and will from time to time immediately upon the conception or development of any
Intellectual Property in the course of Consultant’s engagement  

  
 3 

 
with the Company assign to the Company all of his right, title and interest in and to all such Intellectual Property (whether or not patentable, registrable, recordable or protectable by
copyright and regardless of whether the Company pursues any of the foregoing). If any Intellectual Property falls within the definition of “work made for hire,” as such term is defined in 17 U.S.C. § 101, such Intellectual Property
will be considered “work made for hire,” and the copyright of such Intellectual Property will be owned solely and exclusively by the Company. If any Intellectual Property does not fall within such definition of “work made for
hire”, then the right, title, and interest in and to such Intellectual Property of Consultant will be assigned to the Company pursuant to the first sentence of this Section 10(b). 

(c) Consultant will execute and deliver any assignment instruments and do all other things reasonably requested by the Company (both
during and after Consultant’s engagement with the Company) in order to more fully vest in the Company sole and exclusive right, title, and interest in and to all Intellectual Property. Consultant agrees to cooperate with and provide reasonable
assistance to the Company in the preparation of applications for letters patent, copyright, and other forms of protection for Intellectual Property, including but not limited to the execution and delivery of any instruments reasonably requested by
the Company (both during and after Consultant’s engagement with the Company), in order to protect the Company’s interest in and to all Intellectual Property. If the Company is unable for any reason to secure Consultant’s signature on
any lawful and necessary document required to apply for or execute any patent, trademark, copyright or other applications with respect to any Intellectual Property (including renewals, extensions, continuations, divisions or continuations in part
thereof), Consultant hereby irrevocably designates and appoints the Company and its then current Chief Executive Officer as Consultant’s agent and attorney-in-fact to act for and in behalf and instead of Consultant, to execute and file any such
application and to do all other lawfully permitted acts to further the prosecution and issuance of patents, trademarks, copyrights or other rights thereon with the same legal force and effect as if executed by Consultant. 

11. Confidential Information. 

(a) Consultant acknowledges that during his engagement with Company he will have access to certain highly-sensitive, confidential, and
proprietary information belonging to the Company or third parties who may have furnished such information under obligations of confidentiality, relating to and used in the Company’s business (collectively, “Confidential
Information”). Consultant acknowledges that, unless otherwise available to the public, Confidential Information includes, but is not limited to, the following categories of information and material, including all copies, notes, or other
reproductions or replicas thereof: financial statements and information; budgets, forecasts, and projections; business and strategic plans; marketing, sales, and distribution strategies; research and development projects; records relating to any
intellectual property developed by, owned by, controlled, licensed, or maintained by the Company; information related to the Company’s inventions, research, products, designs, methods, know-how, formulae, techniques, systems, processes;
customer lists; non-public information relating to the Company’s customers, suppliers, employees, distributors, or investors; the specific terms of the Company’s agreements or arrangements, whether oral or written, with any customer,
supplier, vendor, or contractor with which the Company may be associated from time to time; and any and all information relating to the operation of the Company’s business which the Company may from time to time designate as confidential or

  
 4 

 
proprietary or that Consultant reasonably knows should be, or has been, treated by the Company as confidential or proprietary. Confidential Information encompasses all formats in which
information is preserved, whether electronic, print, or any other form, including all originals, copies, notes, or other reproductions or replicas thereof. 

(b) Confidential Information does not include any information that: (i) at the time of disclosure is generally known to, or
readily ascertainable by, the public; (ii) becomes known to the public through no fault of Consultant or other violation of this Agreement; or (iii) is disclosed to Consultant by a third party under no obligation to maintain the
confidentiality of the information. 
 (c) Consultant agrees that he will maintain the confidentiality of the Confidential
Information at all times during and following the Term and will not, directly or indirectly, use or disclose any Confidential Information for any purpose other than to the extent necessary to perform the Services. 

(d) The restrictions in Section 11(c) above will not apply to any information that Consultant is required to disclose by law,
provided that the Consultant (i) notifies the Company of the existence and terms of such obligation, (ii) gives the Company a reasonable opportunity to seek a protective or similar order to prevent or limit such disclosure, and
(iii) only discloses that information actually required to be disclosed. 
 12. Return of Property. Upon termination of Consultant’s
engagement with the Company for any reason, or at any time upon request of the Company, Consultant will promptly deliver to the Company all Confidential Information in any form along with all personal property belonging to the Company that is in
Consultant’s possession, custody, or control, including, without limitation, all files, memoranda, designs, correspondence, manuals, programs, data, records, notes, notebooks, reports, papers, equipment, computer software, proposals, or any
other file, material, document or possession (whether in hard copy or any electronic format), however obtained, along with any reproductions or copies. 

13. Remedies. Consultant acknowledges and agrees that the breach or threatened breach of Sections 10, 11, and/or 12 of this Agreement may result in
immediate and irreparable injury to Company, which injury may not be subject to redress by monetary damages. Accordingly, Consultant agrees that Company is entitled to enforce this Agreement by seeking a temporary restraining order, preliminary and
permanent injunction and/or any other appropriate equitable relief to prevent or retrain such breach. Nothing in this Section prohibits the Company from pursuing any other remedies available to it in law or equity, including but not limited to the
recovery of monetary damages. The Company will be entitled to recover its costs incurred in connection with any action to enforce Sections 10, 11, and/or 12 of this Agreement, including reasonable attorneys’ fees and expenses, to the maximum
extent permitted by law. 
 14. Benefit; Assignment. The rights, duties and obligations of the parties under this Agreement shall inure to the
benefit and shall be binding upon their respective successors and permitted assigns. Neither this Agreement nor the respective rights, duties, obligations and responsibilities of Consultant under this Agreement may be assigned or transferred, in
whole or in part, by Consultant to any other person, association, organization, company or other entity (including subcontractors) without the prior written consent of Company. 

  
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 15. Governing Law; Venue. This Agreement will be governed by and construed in accordance with the laws of
the State of North Carolina, without regard to that body of law known as choice of law. Any litigation arising out of or related to this Agreement will be brought exclusively in any state or federal court in Durham County, North Carolina. Each party
(i) consents to the personal jurisdiction of said courts, (ii) waives any venue or inconvenient forum defense to any proceeding maintained in such courts, and (iii) agrees not to bring any proceeding arising out of or relating to this
Agreement in any other court. 
 16. Miscellaneous. 

(a) The provisions of Sections 7, 8, 9, 10, 11, 12, 13, 14, 15, and 16 will survive the termination of this Agreement for any
reason. 
 (b) Should any provision of this Agreement or the application thereof, to any extent, be held invalid or
unenforceable, the remainder of this Agreement and the application thereof, other than those provisions held invalid or unenforceable, shall not be affected thereby and shall continue valid and enforceable to the fullest extent permitted by law or
equity. 
 (c) No waiver by either party of any breach of this Agreement shall be construed as a waiver of any succeeding
breach of this Agreement. 
 (d) This Agreement may be executed in one or more counterparts, each of which will be deemed an
original but all of which together will constitute one and the same agreement. Facsimile or PDF reproductions of original signatures will be deemed binding for the purpose of the execution of this Agreement. 

(e) This Agreement represents the entire and integrated agreement between the parties and supersedes all prior negotiations,
representations or agreements, either written or oral regarding the subject matter thereof. 
 (f) This Agreement may be
amended only by a written instrument signed by both Company and Consultant. 
 IN WITNESS WHEREOF, the parties hereto have executed this
Agreement to be effective as of the date first above written. 
  

							
	CONSULTANT:	 		 	COMPANY:
		 		 	G1 THERAPEUTICS, INC.:
				
	 /s/ Gregory Mossinghoff
	 		 	By:	 	 /s/ Mark Velleca

	GREGORY MOSSINGHOFF	 		 	Name:	 	 Mark Velleca

		 		 	Title:	 	 CEO

  
 6

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