Document:

EX-10.18.1

 Exhibit 10.18.1 

BIOCEPT, INC. 
 FIRST AMENDMENT TO NOTE AND WARRANT PURCHASE AGREEMENT 

This FIRST AMENDMENT TO NOTE AND
WARRANT PURCHASE AGREEMENT (this “Amendment”), amending the Note and Warrant Purchase Agreement by and among BIOCEPT, INC.,
a California corporation (the “Company”) and the investors listed on the Schedule of Investors attached thereto (the “Investors”) dated as of February 1, 2011 (the “Purchase
Agreement”), is entered into as of July 1, 2011 by and among the Company and the Investors. Capitalized terms used herein which are not defined herein shall have the definition ascribed to them in the Purchase Agreement.

 RECITALS 
 WHEREAS, the Company and the Investors have previously entered into the Purchase Agreement; 
 WHEREAS, Section 6.7 of the Purchase Agreement provides that the Purchase Agreement may be amended with the written consent of (i) the Company and (ii) the holders of
at least a majority in interest of the outstanding Securities (the “Required Holders”); and 
 WHEREAS, the undersigned constitute (i) the Company and (ii) the Required Holders. 
 AGREEMENT 
 NOW,
THEREFORE, in consideration of the foregoing and the promises and covenants contained herein and in the Purchase Agreement, and for other good and valuable consideration, the receipt of which is hereby acknowledged, the parties
hereto agree as follows: 

1.        Recitals.    The reference to
“$5,000,000” in the “whereas” clause contained in the recitals of the Purchase Agreement is hereby amended and restated such that it shall be “$6,000,000.” 

2.        Section 2.5 of the Purchase
Agreement.    The first sentence of Section 2.5 of the Purchase Agreement shall be amended and restated to read in its entirety as follows: 

“On June 1, 2011, the fifth closing of the purchase and sale of the Notes in the principal
amounts set forth opposite each Investor’s name under the heading “Fifth Closing Principal Amount of Note” on the Schedule of Investors attached hereto (the “Fifth Closing”) shall take place.” 

3.        Addition of New Section 2.6 of the Purchase
Agreement.    A new Section 2.6 shall be added to the Purchase Agreement and shall read in its entirety as follows: 

“2.6    Sixth Closing.    On June 30, 2011, the
sixth closing of the purchase and sale of the Notes in the principal amounts set forth opposite each Investor’s name under the heading “Sixth Closing Principal Amount of Note” on the Schedule of Investors attached hereto (the
“Sixth Closing” and each of the Sixth Closing, 

 
Fifth Closing, Fourth Closing, Third Closing, Second Closing and Initial Closing, a “Closing”) shall take place. 

(a)        Deliveries by the
Company. At the Sixth Closing, the Company shall deliver to each Investor participating in the Sixth Closing (a) a duly executed Note (in the principal amount set forth on the Schedule of Investors attached hereto under the heading
“Sixth Closing Principal Amount of Note”) and (b) a duly executed Warrant to purchase the Warrant Shares. 
 (b)        Deliveries by Investors.    At the Sixth Closing, the Investors shall, in the aggregate, deliver to the Company funds, by
check or wire transfer, in the amount set forth on the Schedule of Investors attached hereto under the heading “Sixth Closing Principal Amount of Note.” 

4.        Section 6.6 of the Purchase
Agreement.    The last sentence of Section 6.6 of the Purchase Agreement shall be amended and restated to read in its entirety as follows: 

“All communications shall be sent (i) to the Company at 5810 Nancy Ridge Drive, San Diego,
California 92121, Attn: Chuck Covington, Facsimile No: (858) 320-8261 or (ii) to the Investors at the address shown on the Schedule of Investors, or at such other address as such party may designate by written notice to the other
party.” 
 5.        Schedule of Investors attached to the
Purchase Agreement.    The Schedule of Investors attached to the Purchase Agreement is hereby amended and restated to read in its entirety as set forth on Exhibit A hereto. 

6.        Effect of Amendment.    Except as expressly
modified by this Amendment, the Purchase Agreement shall remain unmodified and in full force and effect. 

7.        Governing Law.    This Amendment shall be
governed by and construed under the laws of the State of California as applied to agreements among California residents, made and to be performed entirely within the State of California without giving effect to its conflicts of laws principles.

 8.        Counterparts.    This Amendment
may be executed in any number of counterparts and signatures delivered by facsimile, each of which shall be deemed an original, but all of which together shall constitute one instrument. 

[REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

 IN WITNESS
WHEREOF, the parties have executed this FIRST AMENDMENT TO NOTE AND WARRANT PURCHASE
AGREEMENT as of the date first written above. 
  

											
	COMPANY	 		 	INVESTORS:
			
	BIOCEPT, INC.
a California corporation	 		 	Reiss Family GST Ex Marital Deduction Trust UDT 12/19/1988
						
	By:  	 	/s/ David F. Hale	 		 	By:  	 	/s/ Claire K.T. Reiss	 	

											
						
	Name:  	 	David F. Hale	 		 	Name:  	 	Claire K.T. Reiss	 	
						
	Title:	 	Executive Chairman	 		 	Title:	 	Trustee	 	
					
		 		 		 	The Reiss Family Survivor’s Trust UDT dated December 19, 1988:	 	

											
						
		 		 		 	By:  	 	/s/ Claire K.T. Reiss	 	

											
						
		 		 		 	Name:  	 	Claire K.T. Reiss	 	
						
		 		 		 	Title:	 	Trustee	 	

 EXHIBIT A 

SCHEDULE OF INVESTORS 
  

													
	INVESTOR NAME	  	INITIAL
CLOSING
PRINCIPAL
AMOUNT
OF
NOTE	  	SECOND
CLOSING
PRINCIPAL
AMOUNT
OF
NOTE	  	THIRD
CLOSING
PRINCIPAL
AMOUNT
OF
NOTE	  	FOURTH
CLOSING
PRINCIPAL
AMOUNT
OF
NOTE	  	FIFTH
CLOSING
PRINCIPAL
AMOUNT
OF
NOTE	  	SIXTH
CLOSING
PRINCIPAL
AMOUNT
OF
NOTE
							
	 The Reiss Family GST
 Exempt
Marital
 Deduction Trust
	  	$1,000,000	  	$0	  	$1,000,000	  	$0	  	$1,000,000	  	To be
determined
							
	 Address:
 9675 La Jolla Farms
Road
 La Jolla, CA 92037
	  		  		  		  		  		  	
							
	 The Reiss Family

Survivor’s Trust UDT
 dated
December 19, 1988
	  	$0	  	$1,000,000	  	$0	  	$1,000,000	  	$0	  	To be
determined
							
	 Address:
 9675 La Jolla Farms
Road
 La Jolla, CA 92037
	  		  		  		  		  		  	
		  	  

	 TOTAL:
	  	$1,000,000	  	$1,000,000	  	$1,000,000	  	$1,000,000	  	$1,000,000	  	$1,000,0001

  
  
  

 
  
  

 
  
 1 $1,000,000
in the aggregate to be lent by The Reiss Family GST Exempt Marital Deduction Trust and/or The Reiss Family Survivor’s Trust UDT dated December 19, 1988.EX-10.18.2

 Exhibit 10.18.2 

BIOCEPT, INC. 
 SECOND AMENDMENT TO NOTE AND WARRANT PURCHASE AGREEMENT 

This SECOND AMENDMENT TO NOTE AND
WARRANT PURCHASE AGREEMENT (this “Amendment”), amending the Note and Warrant Purchase Agreement by and among BIOCEPT, INC.,
a California corporation (the “Company”), and the investors listed on the Schedule of Investors attached thereto (the “Investors”), dated as of February 1, 2011, and amended as of July 1,
2011 (as amended, the “Purchase Agreement”), is entered into as of August 1, 2011 by and among the Company and the Investors. Capitalized terms used herein which are not defined herein shall have the definition ascribed
to them in the Purchase Agreement. 
 RECITALS 

WHEREAS, the Company and the Investors have previously entered into the Purchase Agreement;

 WHEREAS, Section 6.7 of the Purchase Agreement provides that the Purchase
Agreement may be amended with the written consent of (i) the Company and (ii) the holders of at least a majority in interest of the outstanding Securities (the “Required Holders”); and 

WHEREAS, the undersigned constitute (i) the Company and (ii) the Required Holders.

 AGREEMENT 
 NOW, THEREFORE, in consideration of the foregoing and the promises and covenants contained herein and in the Purchase Agreement, and for other good and valuable
consideration, the receipt of which is hereby acknowledged, the parties hereto agree as follows: 

1.        Recitals.    The reference to
“$6,000,000” in the “whereas” clause contained in the recitals of the Purchase Agreement is hereby amended and restated such that it shall be “$12,000,000.” 

2.        Section 2.6 of the Purchase
Agreement.    The first sentence of Section 2.6 of the Purchase Agreement shall be amended and restated to read in its entirety as follows: 

“On July 1, 2011, the sixth closing of the purchase and sale of the Notes in the principal
amounts set forth opposite each Investor’s name under the heading “Sixth Closing Principal Amount of Note” on the Schedule of Investors attached hereto (the “Sixth Closing”) shall take place.” 

3.        Addition of New Section 2.7 of the Purchase
Agreement.    A new Section 2.7 shall be added to the Purchase Agreement and shall read in its entirety as follows: 

“2.7    Seventh Closing.    On August 1, 2011,
the seventh closing of the purchase and sale of the Notes in the principal amounts set forth opposite each Investor’s name under the heading “Seventh Closing Principal Amount of Note” on the Schedule of Investors attached hereto (the
“Seventh Closing”) shall take place. 

(a)        Deliveries by the
Company.    At the Seventh Closing, the Company shall deliver to each Investor participating in the Seventh Closing (a) a duly executed Note (in the principal amount set forth on the Schedule of Investors attached hereto
under the heading “Seventh Closing Principal Amount of Note”) and (b) a duly executed Warrant to purchase the Warrant Shares. 

(b)        Deliveries by
Investors.    At the Seventh Closing, the Investors shall, in the aggregate, deliver to the Company funds, by check or wire transfer, in the amount set forth on the Schedule of Investors attached hereto under the heading
“Seventh Closing Principal Amount of Note.” 
 4.        Addition of New
Section 2.8 of the Purchase Agreement.    A new Section 2.8 shall be added to the Purchase Agreement and shall read in its entirety as follows: 

“2.8    Additional Closings.    At any time
within six months following the Seventh Closing, the Company may sell up to the balance of the authorized Notes and Warrants not sold at the Seventh Closing, Sixth Closing, Fifth Closing, Fourth Closing, Third Closing, Second Closing and Initial
Closing to such persons as may be approved by the Chief Executive Officer of the Company (the “Additional Investors”). With respect to any such additional closing (each an “Additional Closing” and each
of the Additional Closings, Seventh Closing, Sixth Closing, Fifth Closing, Fourth Closing, Third Closing, Second Closing and Initial Closing, a “Closing”) all such sales at such Additional Closing shall be made on the terms
and conditions set forth in this Agreement. This Agreement, including without limitation, the Schedule of Investors, may be unilaterally amended by the Company without the consent of the Investors to include any Additional Investors. Any Notes and
Warrants sold pursuant to this Section 2.8 shall be deemed to be “Notes” and “Warrants” for all purposes under this Agreement, and any Additional Investors thereof shall be deemed to be “Investors” for all purposes
under this Agreement. 

(a)        Deliveries by the
Company.    At each Additional Closing, the Company shall deliver to each Additional Investor participating in such Additional Closing (a) a duly executed Note (in the principal amount of such Additional Investor’s
Loan Amount) and (b) a duly executed Warrant to purchase the Warrant Shares. 
 (b)        Deliveries by Investors.    At each Additional Closing, each Additional Investor participating in such Additional Closing
shall deliver to the Company funds, by check or wire transfer, in the amount of such Additional Investor’s portion of the Loan Amount.” 
 5.        Schedule of Investors attached to the Purchase Agreement.    The Schedule of Investors attached to the Purchase Agreement is
hereby amended and restated to read in its entirety as set forth on Exhibit A hereto. 

 6.        Effect of
Amendment.    Except as expressly modified by this Amendment, the Purchase Agreement shall remain unmodified and in full force and effect. 

7.        Governing Law.    This Amendment shall be
governed by and construed under the laws of the State of California as applied to agreements among California residents, made and to be performed entirely within the State of California without giving effect to its conflicts of laws principles.

 8.        Counterparts.    This Amendment
may be executed in any number of counterparts and signatures delivered by facsimile, each of which shall be deemed an original, but all of which together shall constitute one instrument. 

[REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

 IN WITNESS WHEREOF, the
parties have executed this SECOND AMENDMENT TO NOTE AND WARRANT PURCHASE AGREEMENT as of the date first
written above. 
  

											
	COMPANY	 		 	INVESTORS:
			
	BIOCEPT, INC.
a California corporation	 		 	Reiss Family GST Ex Marital Deduction Trust UDT 12/19/1988
						
	By:  	 	/s/ David F. Hale	 		 	By:  	 	/s/ Claire K.T. Reiss	 	

											
						
	Name:  	 	David F. Hale	 		 	Name:  	 	Claire K.T. Reiss	 	
						
	Title:	 	Executive Chairman	 		 	Title:	 	Trustee	 	
					
		 		 		 	The Reiss Family Survivor’s Trust UDT dated December 19, 1988:	 	

											
						
		 		 		 	By:  	 	/s/ Claire K.T. Reiss	 	

											
						
		 		 		 	Name:  	 	Claire K.T. Reiss	 	
						
		 		 		 	Title:	 	Trustee	 	

 EXHIBIT A 

SCHEDULE OF INVESTORS 
  

															
	INVESTOR NAME	  	INITIAL
CLOSING
PRINCIPAL
AMOUNT
OF
NOTE	  	SECOND
CLOSING
PRINCIPAL
AMOUNT
OF
NOTE	  	THIRD
CLOSING
PRINCIPAL
AMOUNT
OF
NOTE	  	FOURTH
CLOSING
PRINCIPAL
AMOUNT
OF
NOTE	  	FIFTH
CLOSING
PRINCIPAL
AMOUNT 
OF
NOTE	  	SIXTH
CLOSING
PRINCIPAL
AMOUNT
OF
NOTE	  	SEVENTH
CLOSING
PRINCIPAL
AMOUNT
OF
NOTE
								
	 The Reiss Family GST
 Exempt
Marital
 Deduction Trust
	  	$1,000,000	  	$0	  	$1,000,000	  	$0	  	$1,000,000	  	$0	  	To be
determined
								
	 Address:
 9675 La Jolla
Farms
 Road
 La Jolla, CA
92037
	  		  		  		  		  		  		  	
								
	 The Reiss Family

Survivor’s Trust UDT
 dated
December 19, 1988
	  	$0	  	$1,000,000	  	$0	  	$1,000,000	  	$0	  	$1,000,000	  	To be
determined
								
	 Address:
 9675 La Jolla
Farms
 Road
 La Jolla, CA
92037
	  		  		  		  		  		  		  	
		  	  

	 TOTAL:
	  	$1,000,000	  	$1,000,000	  	$1,000,000	  	$1,000,000	  	$1,000,000	  	$1,000,000	  	$1,000,0001

  
  
  

 
  

 
 1 $1,000,000 in the aggregate to be lent by The Reiss Family GST Exempt
Marital Deduction Trust and/or The Reiss Family Survivor’s Trust UDT dated December 19, 1988.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00221-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00221-of-00352.parquet"}]]