Document:

EXHIBIT 10.1

                             SUBSCRIPTION AGREEMENT

Applied DNA Sciences, Inc.
25 Health Sciences Drive, Suite 113
Stony Brook,  New York 11790

Gentlemen and Ladies:

      The undersigned (the  "Subscriber")  hereby subscribes for ________ units,
at a price of  $50,000  per unit,  each  consisting  of (i) a $50,000  principal
amount 10% Secured Convertible  Promissory Note (each a "Note," or collectively,
the  "Notes")  of  Applied  DNA  Sciences,   Inc.,  a  Nevada  corporation  (the
"Company"), and (ii) a warrant to purchase 100,000 shares of common stock of the
Company,  exercisable  for a  period  of  four  years  commencing  on the  first
anniversary  of the date of the  initial  closing of the  Offering at a price of
$0.50 per share  (each a  "Warrant,"  or  collectively,  the  "Warrants").  Each
Warrant may be redeemed  at the option of the Company at a  redemption  price of
$0.001 upon the earlier of (i) the date three years from  issuance  and (ii) the
date a registration  statement for the resale of the underlying common stock has
been  declared  or  remains  effective  by  the  U.S.  Securities  and  Exchange
Commission,  and the Company's stock has traded on The Over the Counter Bulletin
Board at or above $1.00 per share for 20 consecutive trading days. The Notes and
accrued but unpaid interest  thereon are convertible into shares of common stock
of the  Company  at a price of $0.50 per share by the holder of the Notes at any
time from their date of issuance through the first  anniversary of such date and
shall automatically convert on such anniversary at a 20% discount to the average
of the closing bid prices of the  Company's  common stock on trading days during
the 12  months  prior to such  conversion.  In  addition,  at any time  prior to
conversion,  the Company will have the right to prepay the Notes and accrued but
unpaid interest thereon upon 3 days notice,  such notice to allow the holders of
the Notes to convert  the Notes to shares of common  stock of the  Company or be
repaid their respective principal and interest.

      Until the principal and interest owed under the Notes are paid in full, or
converted  into  common  stock of the  Company,  the Notes  will be secured by a
security  interest in all of the assets of the Company.  This security  interest
will be pari  passu  with  the  security  interest  granted  to the  holders  of
$1,500,000 of $50,000  principal  amount secured  convertible  promissory  notes
bearing  interest at 10% per annum  issued as part of an offering  completed  on
March 8, 2006 (the "March  Notes").  The Company may issue up to  $4,500,000  of
debt in addition to the amounts  sold in the  Offering  that may be secured by a
security interest in all of the Company's  assets,  which would be pari passu to
the security interest granted to the holders of the Notes and the March Notes.

      The  Notes  bear  interest  at the rate of 10% per  annum  payable  on the
Maturity Date (as defined below).  Any principal  payment of or interest payment
on the unpaid  principal  amount of the Notes,  whether  at the  Maturity  Date,
acceleration  or  otherwise,  shall  bear  interest  at the lesser of 12% or the
maximum  rate  permissible  by law.  All  principal  and all  accrued and unpaid
interest  under  the  Notes  shall  be  payable  in full on the  date  15-months
subsequent  to the date of the  initial  closing of the  Offering,  referred  to
hereinafter as the "Maturity Date."

      1.  Subscription.   Subject  to  the  terms  and  conditions  hereof,  the
Subscriber  agrees  to pay  $__________________  by  check or wire  transfer  of
immediately  available funds as consideration  for the Subscriber's  Note(s) and
the  Warrant(s).  The  Subscriber  tenders  herewith a check made payable at the
direction of the Company or wire transfer, in the amount of $__________________.
The Subscriber  acknowledges and agrees that this subscription is irrevocable by
the Subscriber but is subject to acceptance by the Company.

      2.  Security.  Until the  principal  and interest owed under the Notes are
paid in full, or converted  into common stock of the Company,  the Notes will be
secured  by a  security  interest  in all of the  assets  of the  Company.  This
security  interest will be pari passu with the security  interest granted to the
holders of $1,500,000 of $50,000 principal amount secured convertible promissory

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notes bearing interest at 10% per annum issued as part of an offering  completed
on March 8, 2006 (the "March Notes").  The Company may issue up to $4,500,000 of
debt in addition to the amounts  sold in the  Offering  that may be secured by a
security interest in all of the Company's  assets,  which would be pari passu to
the security interest granted to the holders of the Notes and the March Notes.

      3. Closing. The Subscriber understands and agrees that the Company intends
to make an initial closing of this offering of units in the Company on or before
April 26, 2006, but that the same may be extended for three additional  periods,
each such  period not to exceed  thirty (30) days,  at the sole  decision of the
Company,  without notice to any  Subscriber.  If the Company does not accept the
Subscriber  prior  to the  initial  closing,  this  Subscription  Agreement  and
Confidential  Offering  Questionnaire,  together with the Subscriber's funds and
any other documents delivered to the Company,  shall be promptly returned to the
Subscriber.

      4. Subscription  Compliance.  The Subscriber agrees that this subscription
is subject to the following terms and conditions:

      The Company shall have the right, in its sole  discretion,  to: (i) accept
      or reject this  subscription;  (ii)  determine  whether this  Subscription
      Agreement  has  been  properly  completed  by  the  Subscriber  and  (iii)
      determine whether the Subscriber has met all of the Company's requirements
      for  investment in a Note. If the Company  deems this  subscription  to be
      defective,  deficient  or otherwise  non-compliant  with the terms of this
      offering,  the  Subscriber's  funds  will  be  returned  promptly  to  the
      Subscriber without interest or deduction.

      5. Receipt of Information.

            a. The Subscriber and Subscriber's purchaser representative, if any,
      have  received  a copy  of the  Confidential  Private  Placement  Offering
      Memorandum.  The  Subscriber,  either alone or together with  Subscriber's
      purchaser  representative,  if any, have such  knowledge and experience in
      financial  and  business  matters as to be able to evaluate the merits and
      risks of an investment in the Company.

            b. The Subscriber and Subscriber's representative,  if any, have had
      the  opportunity to ask questions of and receive  answers from the Company
      concerning  the terms and  conditions  of the offering of the Units by the
      Company and to obtain any additional  information Subscriber has requested
      which is necessary to verify the accuracy of the information  furnished to
      the Subscriber concerning the Company and such offering.

      6.  Representations of Subscriber.  In connection with the purchase of the
Note, the Subscriber hereby represents and warrants to the Company as follows:

            a. If the Subscriber is an individual  purchaser of the unit(s), the
      Subscriber represents and warrants that he/she is at least 25 years of age
      and a resident of the Country of  _______________  and is not nor has ever
      been a "U.S.  person," as defined in Rule 902 of  Regulation S promulgated
      under the Securities Act of 1933, as amended (the "Act").

            b. If the Subscriber is a Company,  trust or other corporate  entity
      purchaser of the unit(s),  the Subscriber  represents and warrants that it
      is duly  organized and validly  existing  under the laws of the Country of
      _______________,  and has all requisite powers to purchase the unit(s). If
      the  subscriber is a trust,  none of the trustees are a "U.S.  person," as
      defined in Rule 902 of Regulation S promulgated under the Act.

            c. The Subscriber is an "accredited investor" as defined in Rule 501
      of Regulation D promulgated under the Act.

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            d. The unit(s) is being purchased for the  Subscriber's  own account
      without the participation of any other person,  with the intent of holding
      the  unit(s)  for  investment  and  without  the intent of  participating,
      directly or indirectly,  in a  distribution  of the unit(s) and not with a
      view to, or for a resale  in  connection  with,  any  distribution  of the
      unit(s)  or any  portion  thereof,  nor is the  undersigned  aware  of the
      existence of any  distribution of the Company's  securities.  Furthermore,
      the  undersigned  has no present  intention of dividing  such unit(s) with
      others or reselling or otherwise disposing of any portion of such unit(s),
      either currently or after the passage of a fixed or determinable period of
      time, or upon the occurrence or nonoccurrence of any  predetermined  event
      or circumstance.

            e. The  Subscriber  has no need for  liquidity  with  respect to his
      purchase  of a  unit(s)  and is  able  to  bear  the  economic  risk of an
      investment in the unit(s) for an indefinite  period of time and is further
      able to afford a complete loss of such investment.

            f. The Subscriber  represents  that his financial  commitment to all
      investments  (including  his  investment  in the  Company)  is  reasonable
      relative to his net worth and liquid net worth.

            g. The Subscriber  recognizes  that the unit(s) will be: (i) sold to
      the  Subscriber  without  registration  under any United States federal or
      other law relating to the registration of securities for sale; (ii) issued
      and sold in reliance on the exemption from  registration  under the Nevada
      Securities  Act, as amended (the "Nevada  Act");  (iii) issued and sold in
      reliance on the  exemption  from  registration  under the Act  provided by
      Section  4(2) of the Act;  and (iv) issued and sold to  non-United  States
      persons, as defined in Section 902(k) under Regulation S promulgated under
      the Act.

            h. The  Subscriber is aware that any resale of the unit(s) cannot be
      made except in accordance with Regulation S promulgated under the Act, the
      registration requirements of the Act or another exemption therefrom.

            i. The Subscriber  represents and warrants that all offers and sales
      of the unit(s) shall be made in accordance  with Regulation S, pursuant to
      an exemption from  registration  under the Act or pursuant to registration
      under the Act, and the Subscriber  will not engage in any hedging or short
      selling  transactions  with regard to the unit(s) or the underlying common
      stock.

            j. The  Subscriber  is not  acquiring  the  unit(s)  based  upon any
      representation,  oral or written, by any person with respect to the future
      value of, or income  from,  the  unit(s)  but rather  upon an  independent
      examination and judgment as to the prospects of the Company.

            k. The  Subscriber  understands  that the  Company is an early stage
      Company and lacks an operating  history.  The Subscriber  appreciates  and
      understands  the risks involved with investing in a Company with a limited
      operating  history and has read and understands the risk factors set forth
      in the Confidential Private Placement Memorandum and the exhibits thereto.

            l. The Company, by and through itself and/or legal counsel, has made
      no representations or warranties as to the suitability of the Subscriber's
      investment  in the  Company,  the length of time the  undersigned  will be
      required to own the unit(s),  or the profit to be  realized,  if any, as a
      result of investment  in the Company.  Neither the Company nor its counsel
      has made an independent investigation on behalf of the Subscriber, nor has
      the  Company,  by and through  itself and  counsel,  acted in any advisory
      capacity to the Subscriber.

            m. The Company, by and through itself and/or legal counsel, has made
      no  representations  or warranties that the past performance or experience
      on the part of the

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      Company,   or  any  partner  or  affiliate,   their  partners,   salesmen,
      associates,  agents, or employees or of any other person,  will in any way
      indicate the predicted results of the ownership of the unit(s).

            n. The Company has made available for inspection by the undersigned,
      and his  purchaser  representative,  if any,  the books and records of the
      Company.  Upon reasonable notice,  such books and records will continue to
      be made  available for  inspection  by investors  upon  reasonable  notice
      during normal  business  hours at the  principal  place of business of the
      Company.

            o.  The  unit(s)  was not  offered  to the  Subscriber  by  means of
      publicly  disseminated  advertisement  or  sales  literature,  nor  is the
      Subscriber aware of any offers made to other persons by such means.

            p. All information  which the Subscriber has provided to the Company
      concerning the Subscriber is correct and complete as of the date set forth
      at the end of this  Subscription  Agreement,  and if there  should  be any
      material   adverse   change  in  such   information   prior  to  receiving
      notification  that this  subscription  has been accepted,  the undersigned
      will immediately provide the Company with such information.

      7. Agreements of Subscriber. The Subscriber agrees as follows:

            a. The sale of the unit(s) by the  Company has not been  recommended
      by any United States federal or other securities  commission or regulatory
      authority.  Furthermore,  the foregoing authorities have not confirmed the
      accuracy or determined the adequacy of this Subscription  Agreement or the
      Confidential Private Placement Offering Memorandum.

            b. The unit(s) and the  underlying  common stock will not be offered
      for sale,  sold, or  transferred  other than pursuant to: (i) an effective
      registration  under the Nevada Act or in a transaction  which is otherwise
      in compliance  with the Nevada Act; (ii) an effective  registration  under
      the Act or in a  transaction  otherwise  in  compliance  with the Act; and
      (iii)  evidence  satisfactory  to  the  Company  of  compliance  with  the
      applicable  securities laws of other  jurisdictions.  The Company shall be
      entitled  to rely  upon an  opinion  of  counsel  satisfactory  to it with
      respect to compliance with the above laws.

            c. The Company is under no  obligation to register the unit(s) or to
      comply  with  any  exemption  available  for sale of the  unit(s)  without
      registration,  and the  information  necessary to permit  routine sales of
      securities  of the Company  under Rule 144 of the Act may not be available
      when you  desire  to  resell  them  pursuant  to Rule 144 of the Act.  The
      Company is under no obligation to act in any manner so as to make Rule 144
      available with respect to the unit(s).

            d.  There  is no  established  market  for the  units  and it is not
      anticipated  that any  public  market  for the units  will  develop in the
      future.

            e. The Company may, if it so desires,  refuse to permit the transfer
      of the  unit(s)  unless the  request for  transfer  is  accompanied  by an
      opinion of counsel  acceptable  to the Company to the effect that  neither
      the sale nor the proposed transfer will result in any violation of the Act
      or the applicable securities laws of any other jurisdiction.

            f. A legend  indicating  that the unit(s) and the underlying  common
      stock have not been registered under such securities laws and referring to
      the restrictions and  transferability of unit(s) and the underlying common
      stock may be placed on the  certificates  or instruments  delivered to the
      Subscriber  or any  substitutes  thereof  and any  transfer  agent  of

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<PAGE>

      the Company may be instructed to require compliance therewith. The unit(s)
      is further subject to restriction of transfer as set forth in the By-laws.

      8. Indemnification of the Company. The undersigned understands the meaning
and legal consequences of the representations  and warranties  contained herein,
and hereby agrees to indemnify and hold  harmless,  the Company,  its respective
agents, officers,  managers and affiliates from and against any and all damages,
losses, costs and expenses (including  reasonable attorneys' fees) which they or
any of them may incur by reason of the failure of the  Subscriber to fulfill any
of the terms of this Subscription  Agreement,  or by reason of any breach of the
representations and warranties made by the Subscriber herein, or in any document
provided by the Subscriber to the Company.

      9. Representative  Capacity. If an investment in the Company is being made
by a corporation,  trust or estate, the undersigned individual signing on behalf
of the  Subscriber,  represents  that he has all  right  and  authority,  in his
capacity  as  an  officer,   managing   member,   trustee,   executor  or  other
representative of such corporation, trust or estate, as the case may be, to make
such  decision  to  invest  in the  Company  and to  execute  and  deliver  this
Subscription  Agreement  on behalf of such  corporation,  trust or estate as the
case  may  be,  enforceable  in  accordance  with  its  terms.  The  undersigned
individual  also  represent that any such  corporation,  trust or estate was not
formed for the purpose of buying the unit(s) hereby subscribed.

      10. Special Power of Attorney.

            a.  The  Subscriber,   by  executing  this  Subscription  Agreement,
      irrevocably  makes,  constitutes and appoints any executive officer of the
      Company,  and each of them  individually,  as the  undersigned's  true and
      lawful attorney,  for the undersigned and in the undersigned's name, place
      and stead, and for the use and benefit of the undersigned,  to execute and
      acknowledge and, to the extent necessary, to file and record:

                  1. such  certificates,  instruments  and  documents  as may be
            required  to be filed by the  Company  or which  the  Company  deems
            advisable to file under the laws of the State of Nevada or any other
            state or jurisdiction in which the Company transacts business; and

                  2.  all   conveyances   or  other   instruments  or  documents
            necessary,  appropriate or convenient to effect the  dissolution and
            termination of the Company.

            b. Such a power of attorney:

                  1. is a special power of attorney coupled with an interest and
            is irrevocable; and;

                  2. shall survive the death or disability of the Subscriber.

            c. The Subscriber  hereby agrees to be bound by any  representations
      made by the Company or its  substitutes  acting  pursuant to this  Special
      Power of Attorney,  and the undersigned hereby waives any and all defenses
      which may be available to him to contest,  negate or disaffirm its actions
      or the actions of his  substitutes  under this Special  Power of Attorney.
      The powers herein  granted are granted for the sole and exclusive  benefit
      of the undersigned  and not on behalf of any other person,  in whole or in
      part.

      11.  Subscription Not Revocable.  The undersigned hereby  acknowledges and
agrees that the undersigned is not entitled to cancel,  terminate or revoke this
Subscription  Agreement or any agreements of the undersigned  hereunder and that
this Subscription  Agreement shall survive the dissolution,  death or disability
of the undersigned.

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<PAGE>

      12.  Restrictions  on  Transferability.  The  undersigned  understands and
agrees that the purchase and resale, pledge,  hypothecation or other transfer of
the unit(s) is  restricted  by certain  provisions of the By-laws of the Company
and that the  unit(s)  shall not be sold,  pledged,  hypothecated  or  otherwise
transferred  unless the unit(s) is registered under the Act and applicable state
securities laws or an exemption from such registration is available.

      13. Governing Law. This  Subscription  Agreement is being delivered and is
intended to be  performed in the State of New York,  and shall be construed  and
enforced in accordance  with,  and the law of such state shall govern the rights
of parties.

      14. Numbers and Gender.  In this Agreement,  the masculine gender includes
the feminine gender and the neuter and the singular  includes the plural,  where
appropriate to the context.

         THIS SPACE INTENTIONALLY LEFT BLANK; SIGNATURE PAGE FOLLOWS

<PAGE>

                           APPLIED DNA SCIENCES , INC.
                                SIGNATURE PAGE TO
                             SUBSCRIPTION AGREEMENT

      Subscriber  hereby elects to subscribe under the Subscription  Agreement
for a total of  $______________ of UNITS (NOTE: to be completed by subscriber)
and executes the Subscription Agreement.

      IN  WITNESS  WHEREOF,  the  undersigned  has  executed  this  Subscription
Agreement on the date set forth below.

Date of Execution: ___________, 2006

                             IF INDIVIDUAL INVESTOR:

                                   -------------------------------------
                                   (Signature)

                                   -------------------------------------
                                   (Printed Name)

                             IF CORPORATION, TRUST,
                              ESTATE OR REPRESENTATIVE:

                                   -------------------------------------
                                   Name of Investor

                                   By:
                                       --------------------------------
                                   Name:
                                   Title:

                    (Investors do not write below this line)
--------------------------------------------------------------------------------

APPROVED THIS ____ DAY OF ___________, 2006

APPLIED DNA SCIENCES, INC.

By:
    --------------------------
Name:
Title:

                                       7EXHIBIT 10.2

THIS NOTE AND THE COMMON STOCK  REFERENCED  HEREIN HAVE NOT BEEN REGISTERED WITH
OR  APPROVED  OR  DISAPPROVED  BY THE  UNITED  STATES  SECURITIES  AND  EXCHANGE
COMMISSION OR ANY STATE  SECURITIES  COMMISSION OR REGULATORY  AUTHORITY AND ARE
BEING OFFERED PURSUANT TO AN EXEMPTION FROM REGISTRATION UNDER THE UNITED STATES
SECURITIES ACT OF 1933, AS AMENDED (THE "SECURITIES ACT").

THE SALE,  ASSIGNMENT,  CONVEYANCE,  PLEDGE,  HYPOTHECATION  OR  TRANSFER OF THE
SECURITIES  REPRESENTED  BY THIS  NOTE OR THE  UNDERLYING  COMMON  STOCK TO U.S.
PERSONS,  AS  DEFINED  IN RULE  902(k) OF  REGULATION  S  PROMULGATED  UNDER THE
SECURITIES  ACT, IS PROHIBITED  EXCEPT (1) IN ACCORDANCE  WITH THE PROVISIONS OF
REGULATION  S  AS  PROMULGATED   UNDER  THE  SECURITIES  ACT;  (2)  PURSUANT  TO
REGISTRATION UNDER THE SECURITIES ACT; OR (3) PURSUANT TO AN AVAILABLE EXEMPTION
FROM REGISTRATION UNDER THE SECURITIES ACT.

This  note is one of a series  of  notes  (the  "Serial  Notes")  issued  in the
aggregate principal amount of $7,000,000.

                           APPLIED DNA SCIENCES, INC.

May ___, 2006                                                  $________________

                  10% SECURED CONVERTIBLE PROMISSORY NOTE

Applied DNA Sciences,  Inc., a Nevada  corporation  (the  "Company"),  for value
received,  hereby  promises  to  pay  to   ______________________________   (the
"Holder,"  which  term shall in every  instance  refer to any owner or holder of
this Note) at  ________________________________  or at any other  place that the
Holder  may  designate  in  writing  to the  Company,  on August  __,  2007 (the
"Maturity Date"), the principal sum of _____________________ THOUSAND AND NO/100
DOLLARS ($______) in such coin or currency of the United States of America as at
the time of payment  shall be legal tender for the payment of public and private
debts,  and to pay interest on the outstanding  principal sum hereof at the rate
of ten percent (10%) per annum. Any principal payment or interest payment on the
unpaid  principal amount of this Note not paid when due, whether at the Maturity
Date, by acceleration or otherwise,  shall bear interest at twelve percent (12%)
or the maximum rate permissible by law, whichever is less (the "Default Interest
Rate").  Payment of principal and accrued and unpaid interest,  if any, shall be
payable on the  Maturity  Date in like coin or currency to the Holder  hereof at
the address of the Holder on file with the Company or at such other place as the
Holder shall have  notified the Company in writing at least five (5) days before
the Maturity Date, provided that any payment otherwise due on a Saturday, Sunday
or legal bank holiday may be paid on the following business day.

This Note is secured by a security  interest in all the assets of the Company as
set forth in Section 4(e) hereof (the "Security Agreement"). Reference herein to
the Security  Agreement  shall in no way impair the  absolute and  unconditional
obligation of the Company to pay both principal and interest  hereon as provided
herein.

The rights and  remedies  of the Holder  hereunder  are subject to the terms and
conditions  of  the  Security  Agreement  and  the  provisions  of  the  Uniform
Commercial Code as enacted in

                                       1
<PAGE>

the State of Nevada including,  without  limitation,  powers with respect to the
enforceability and collectibility of all amounts due hereunder. Reference to the
Uniform  Commercial  Code  of  the  State  of  Nevada  is  made  for a  complete
description of the rights, powers and obligations of the Holder.

1. Transfers of Note to Comply with the Securities Act

THE HOLDER AGREES THAT THIS NOTE AND THE COMMON STOCK  ISSUABLE UPON  CONVERSION
OF THE NOTE MAY NOT BE SOLD,  TRANSFERRED,  PLEDGED,  HYPOTHECATED  OR OTHERWISE
DISPOSED OF EXCEPT (1) IN  ACCORDANCE  WITH THE  PROVISIONS  OF  REGULATION S AS
PROMULGATED  UNDER THE SECURITIES  ACT; (2) PURSUANT TO  REGISTRATION  UNDER THE
SECURITIES ACT; OR (3) PURSUANT TO AN AVAILABLE EXEMPTION THEREFROM.

2. Prepayment; Repayment Upon Consolidation or Merger

      (a) The  principal  amount of this Note may be prepaid by the Company,  in
whole or in part, on three days prior written notice without premium or penalty,
at any time.  Upon any prepayment of the entire  principal  amount of this Note,
all  accrued,  but unpaid,  interest  shall be paid to the Holder on the date of
prepayment.  The date upon which the  Company  prepays  the  principal  plus all
accrued and unpaid interest due on this Note shall be hereinafter referred to as
the "Prepayment  Date."  Notwithstanding  the foregoing  right of payment,  upon
receipt of the three day notice, the Holder shall have the conversion rights set
forth under Section 3(b) hereof, regardless of when said three day prior written
notice is given.

      (b) This Note  shall be paid in full,  without  premium,  in the event the
Company consolidates or merges with another corporation,  unless (i) the Company
shall be the surviving  corporation in such  consolidation or merger or (ii) the
other corporation controls, is under common control with or is controlled by the
Company  immediately  prior to the  consolidation  or merger  whether or not the
Company shall be the surviving  corporation in such  consolidation or merger, in
which  event  this  Note  shall  remain  outstanding  as an  obligation  of  the
consolidated or surviving corporation.

3. Conversion of Note

      (a)  This  Note  and  any  accrued  and  unpaid   interest   hereon  shall
automatically  convert  into shares of Common  Stock of the  Company,  par value
$0.001 per share (the  "Common  Stock"),  on the first  anniversary  of the date
hereof at a 20%  discount to the average of the closing bid prices of the Common
Stock on The Over The Counter  Bulletin  Board  reported  for all  trading  days
during the 12 months prior to such conversion.

      (b) The Holder shall have the right from time to time,  and at any time on
or prior to the first anniversary of the date hereof, to convert all or any part
of  the  entirety  of  the  principal  and  accrued  but  unpaid  interest  then
outstanding under this Note into fully paid and non-assessable  shares of Common
Stock,  as such Common Stock exists on the issue date,  or any shares of capital
stock or other  securities  of the Company  into which such  Common  Stock shall
hereafter be changed or  reclassified  at a conversion  price equal to $0.50 per
share.

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<PAGE>

4. Covenants of Company

The Company  covenants and agrees that, so long as any principal of, or interest
on, this Note shall remain unpaid,  unless the Holder shall otherwise consent in
writing, it will comply with the following terms:

      (a) Reporting Requirements. The Company will furnish to the Holder:

            (i) as soon as possible, and in any event within ten (10) days after
      obtaining  knowledge  of the  occurrence  of (A) an Event of  Default,  as
      hereinafter  defined, (B) an event which, with the giving of notice or the
      lapse of time or both,  would  constitute  an Event of  Default,  or (C) a
      material  adverse  change in the  condition  or  operations,  financial or
      otherwise,  of the Company,  taken as whole, the written  statement of the
      Chief  Executive  Officer or the Chief  Financial  Officer of the Company,
      setting  forth the  details of such Event of  Default,  event or  material
      adverse  change and the action  which the  Company  proposes  to take with
      respect thereto;

            (ii)  promptly  after the sending or filing  thereof,  copies of all
      financial  statements,   reports,  certificates  of  its  Chief  Executive
      Officer,  Chief  Financial  Officer or accountants  and other  information
      which the Company or any  subsidiary  sends to any holders  (other than to
      holders of the Serial Notes) of its securities;

            (iii)  promptly  after  the  commencement  thereof,  notice  of each
      action,  suit  or  proceeding  before  any  court  or  other  governmental
      authority or other  regulatory body or any arbitrator as to which there is
      a reasonable  possibility  of a  determination  that would (A)  materially
      impact  the  ability  of the  Company or any  subsidiary  to  conduct  its
      business, (B) materially and adversely affect the business,  operations or
      financial  condition  of the Company  taken as a whole,  or (C) impair the
      validity  or  enforceability  of the  Serial  Notes or the  ability of the
      Company to perform its obligations under the Serial Notes;

            (iv) promptly upon request,  such other  information  concerning the
      condition or  operations,  financial or  otherwise,  of the Company as the
      Holder from time to time may reasonably request.

      (b) Taxes. The Company has filed or will file all federal, state and local
tax returns  required to be filed or sent or has  obtained  extensions  thereof.
Except as otherwise disclosed, the Company has timely paid or made provision for
all taxes shown as due and payable on its tax returns required to be filed prior
to the date hereof and all  assessments  received by the Company and will timely
pay all taxes that will be shown as due and payable on its tax returns  required
to be filed after the date hereof,  except to the extent that the Company  shall
be  contesting   such  taxes  and  assessments  in  good  faith  by  appropriate
proceedings.

      (c)  Compliance  with Laws.  The  Company  will  comply,  in all  material
respects with all applicable laws, rules,  regulations and orders, except to the
extent  that  noncompliance  would not have a material  adverse  effect upon the
business, operations or financial condition of the Company taken as a whole.

      (d)  Keeping  of  Records  and Books of  Account.  The  Company  will keep
adequate records and books of account,  with complete entries made in accordance
with generally accepted accounting  principles,  reflecting all of its financial
and other business transactions.

                                       3
<PAGE>

      (e) Security Agreement.  In order to secure the obligations of the Company
under this Note and the  Serial  Notes,  the  Company  hereby  grants a security
interest in all of the assets of the Company,  which  security  interest is pari
passu with the  security  interest  granted to the holders of the certain  notes
(the "March Notes") issued as part of a private placement of securities that was
completed  on March 8, 2006,  to the  holders of the Serial  Notes.  The Company
reserves  the right to issue  $4,500,000  of debt in addition to amounts sold in
the  offering,  of which the Serial  Notes are a part,  that may be secured by a
security interest in all of the Company's  assets,  which would be pari passu to
the security  interest  granted to the holders of the Series Notes and the March
Notes.

5. Events of Default and Remedies

      (a) Any one or more of the  following  events (each an "Event of Default")
which  shall  have  occurred  and be  continuing  shall  constitute  an event of
default:

            (i) A default in the payment of the principal or accrued interest on
      this Note or upon any other  indebtedness  of the  Company  after the date
      hereof that is greater  than  $100,000,  as and when the same shall become
      due,  whether by default or otherwise,  which default shall have continued
      for a period of five (5) business days; or

            (ii) Any  representation  or  warranty  made by the  Company  or any
      officer  of  the  Company  in the  Notes,  or in  any  agreement,  report,
      certificate  or other  document  delivered  to the Holder  pursuant to the
      Notes shall have been  incorrect in any  material  respect when made which
      shall not have been  remedied ten (10) days after written  notice  thereof
      shall have been given by the Holder; or

            (iii) The Company  shall fail to perform or observe any  affirmative
      covenant  contained in Section 4 of this Note or any of the Notes and such
      default,  if capable of being  remedied,  shall not have been remedied ten
      (10) days  after  written  notice  thereof  shall  have been  given by the
      Holder; or

            (iv)  The  Company  or  any  subsidiary  (A)  shall   institute  any
      proceeding  or  voluntary  case  seeking  to  adjudicate  it  bankrupt  or
      insolvent,    or   seeking   dissolution,    liquidation,    winding   up,
      reorganization, arrangement, adjustment, protection, relief or composition
      of it or its debts under any law  relating to  bankruptcy,  insolvency  or
      reorganization or relief of debtors, or seeking the entry of any order for
      relief or the  appointment  of a  receiver,  trustee,  custodian  or other
      similar  official  for  such  the  Company  or any  subsidiary  or for any
      substantial  part of its property,  or shall  consent to the  commencement
      against it of such a  proceeding  or case,  or shall file an answer in any
      such case or proceeding  commenced against it consenting to or acquiescing
      in the  commencement  of such case or  proceeding,  or shall consent to or
      acquiesce in the  appointment  of such a receiver,  trustee,  custodian or
      similar  official;  (B) shall be  unable  to pay its  debts as such  debts
      become due, or shall  admit in writing  its  inability  to apply its debts
      generally;  (C)  shall  make a  general  assignment  for  the  benefit  of
      creditors;  or (D) shall take any action to authorize or effect any of the
      actions set forth above in this subsection 5(a)(iv); or

            (v) Any proceeding  shall be instituted  against the Company seeking
      to  adjudicate  it  a  bankrupt  or  insolvent,  or  seeking  dissolution,
      liquidation,   winding  up,   reorganization,   arrangement,   adjustment,
      protection, relief of debtors, or seeking the entry of an order for relief
      or the  appointment  of a receiver,  trustee,  custodian or other  similar
      official for the Company or for any substantial part of its property,  and
      either such  proceeding  shall

                                       4
<PAGE>

      not have been  dismissed  or shall not have  been  stayed  for a period of
      sixty  (60)  days  or  any  of  the  actions  sought  in  such  proceeding
      (including,  without limitation, the entry of any order for relief against
      it or the appointment of a receiver,  trustee,  custodian or other similar
      official for it or for any substantial  part of its property) shall occur;
      or

            (vi) One or more final judgments,  arbitration  awards or orders for
      the  payment  of money in excess of  $250,000  in the  aggregate  shall be
      rendered  against the Company,  which  judgment  remains  unsatisfied  for
      thirty (30) days after the date of such entry.

            (vii)  Delisting  of the Common Stock from the  principal  market or
      exchange  on which the  Common  Stock is  listed  for  trading;  Company's
      failure to comply with the conditions for listing;  or  notification  that
      the Company is not in compliance  with the  conditions  for such continued
      listing.

            (viii)  The  issuance  of an  SEC  stop  trade  order  or  an  order
      suspending  trading  of the  Common  Stock  from the  principal  market or
      exchange  on which the Common  Stock is listed for trading for longer than
      five (5) trading days.

            (ix) The failure by the Company to issue  shares of Common  Stock to
      the Holder  upon  exercise by the Holder of the  conversion  rights of the
      Holder  in  accordance  with the terms of this  Note,  or the  failure  to
      transfer or cause its  transfer  agent to transfer  (electronically  or in
      certificated  form) any  certificate  for shares of Common Stock issued to
      the Holder upon  conversion  of or otherwise  pursuant to this Note as and
      when  required  by this Note,  or the  failure  to remove any  restrictive
      legend (or to withdraw any stop transfer  instructions in respect thereof)
      on any  certificate  for any shares of Common  Stock  issued to the Holder
      upon conversion of or otherwise pursuant to this Note as and when required
      by this Note,  and any such failure  shall  continue  uncured for ten (10)
      days after the Company shall have been notified  thereof in writing by the
      Holder;

            (x) Except as  permitted  herein,  the  Company  shall  encumber  or
      hypothecate the collateral subject to the Security Agreement to any party;

      (b) In the event of and  immediately  upon the  occurrence  of an Event of
Default, the Note shall become immediately due and payable without any action by
the Holder and the Note shall bear interest  until paid at the Default  Interest
Rate.  If an Event of Default  occurs and is  continuing,  Holder may pursue any
available  remedy to collect the payment of all amounts due under the Note or to
enforce the  performance  of any provision of the Note. No waiver of any default
under the Note shall be construed as a waiver of any subsequent default, and the
failure to exercise any right or remedy  thereunder shall not waive the right to
exercise such right or remedy thereafter.

      (c) The  Company  covenants  that in case the  principal  of, and  accrued
interest on, the Note becomes due and payable by declaration or otherwise,  then
the Company  will pay in cash to the Holder of this Note,  the whole amount that
then shall have become due and payable on this Note for  principal  or interest,
as the case may be, and in addition  thereto,  such  further  amount as shall be
sufficient to cover the costs and expenses of collection,  including  reasonable
fees and disbursements of the Holder's legal counsel.  In case the Company shall
fail  forthwith  to pay such  amount,  the  Holder  may  commence  an  action or
proceeding at law or in equity for the collection of the sums so due and unpaid,
and may  prosecute  any such

                                       5
<PAGE>

action or  proceeding  to  judgment  or final  decree  against  Company or other
obligor upon this Note, wherever situated,  the monies adjudicated or decreed to
be payable.

      (d) The  Company  agrees  that it shall  give  notice to the Holder at its
registered address by facsimile,  confirmed by certified mail, of the occurrence
of any Event of Default  within ten (10) days after such Event of Default  shall
have occurred.

6. Unconditional Obligation; Fees, Waivers, Other

      (a) The  obligations  to make the  payments  provided for in this Note are
absolute  and   unconditional   and  not  subject  to  any   defense,   set-off,
counterclaim, rescission, recoupment or adjustment whatsoever.

      (b) If, following the occurrence of an Event of Default, Holder shall seek
to enforce the collection of any amount of principal of and/or  interest on this
Note,  there shall be immediately due and payable from the Company,  in addition
to the then unpaid  principal of, and accrued unpaid interest on, this Note, all
costs  and  expenses  incurred  by Holder in  connection  therewith,  including,
without limitation, reasonable attorneys' fees and disbursements.

      (c) No forbearance,  indulgence, delay or failure to exercise any right or
remedy with respect to this Note shall operate as a waiver or as an acquiescence
in any default,  nor shall any single or partial exercise of any right or remedy
preclude  any other or further  exercise  thereof or the  exercise  of any other
right or remedy.

      (d) This Note may not be modified or discharged  (other than by payment or
conversion) except by a writing duly executed by the Company and Holder.

      (e) Holder hereby  expressly  waives demand and  presentment  for payment,
notice of nonpayment,  notice of dishonor,  protest, notice of protest, bringing
of suit,  and  diligence  in taking  any action to  collect  amounts  called for
hereunder,  and shall be directly  and  primarily  liable for the payment of all
sums  owing  and to be owing  hereon,  regardless  of and  without  any  notice,
diligence,  act or omission with respect to the  collection of any amount called
for hereunder or in connection with any right, lien, interest or property at any
and all times which the  Company  had or is existing as security  for any amount
called for hereunder.

7. Miscellaneous

      (a)  The  headings  of  the  various  paragraphs  of  this  Note  are  for
convenience  of  reference  only and shall in no way  modify any of the terms or
provisions of this Note.

      (b) This Note has been issued by the Company  pursuant to authorization of
the Board of Directors of the Company.

All notices  required or permitted to be given hereunder shall be in writing and
shall be deemed to have been duly given  when  personally  delivered  or sent by
registered  or  certified  mail (return  receipt  requested,  postage  prepaid),
facsimile  transmission or overnight courier to the Holder at the address in the
records of the Company,  to the Company at 25 Health  Sciences Dr., Stony Brook,
New York 11790 or at such other  address as the  intended  recipient  shall have
hereafter  given to the other party hereto  pursuant to the  provisions  of this
Note.

                                       6
<PAGE>

      (c) The Company may  consider and treat the entity in whose name this Note
shall be  registered as the absolute  owner thereof for all purposes  whatsoever
(whether  or not this  Note  shall be  overdue)  and the  Company  shall  not be
affected  by any  notice to the  contrary.  Subject  to the  limitations  herein
stated,  the registered owner of this Note shall have the right to transfer this
Note by assignment,  and the transferee  thereof shall, upon his registration as
owner  of this  Note,  become  vested  with all the  powers  and  rights  of the
transferor. Registration of any new owners shall take place upon presentation of
this  Note  to  the  Company  at its  principal  offices,  together  with a duly
authenticated  assignment.  In  case  of  transfer  by  operation  of  law,  the
transferee agrees to notify the Company of such transfer and of his address, and
to submit  appropriate  evidence regarding the transfer so that this Note may be
registered in the name of the transferee.  This Note is transferable only on the
books of the  Company by the holder  hereof,  in person or by  attorney,  on the
surrender  hereof,  duly endorsed.  Communications  sent to any registered owner
shall be  effective  as  against  all  holders  or  transferees  of the Note not
registered at the time of sending the communication.

      (d) Payments of principal and interest shall be made as specified above to
the  registered  owner of this Note.  No interest  shall be due on this Note for
such period of time that may elapse  between  the  maturity of this Note and its
presentation for payment.

      (e) The Holder shall not, by virtue,  hereof, be entitled to any rights of
a shareholder in the Company, whether at law or in equity, and the rights of the
Holder are limited to those expressed in this Note.

      (f) Upon receipt by the Company of evidence reasonably  satisfactory to it
of the loss, theft,  destruction or mutilation of this Note, and (in the case of
loss, theft or destruction) of reasonably satisfactory indemnification, and upon
surrender and cancellation of this Note, if mutilated, the Company shall execute
and deliver a new Note of like tenor and date.

      (g) Except as otherwise provided herein,  this Note shall be construed and
enforced in accordance  with the laws of the State of New York,  without  giving
effect to the conflicts of law principles thereof or the actual domiciles of the
parties.  The Company and the Holder hereby consent to the  jurisdiction  of the
Courts of the State of New York and the United States  District  Courts situated
therein in connection  with any action  concerning  the  provisions of this Note
instituted by the Holder against the Company.

      (h) The Company  and the  Holder(i)  agree that any legal suit,  action or
proceeding  arising  out  of or  relating  to  this  Note  shall  be  instituted
exclusively  in the New York State Supreme  Court,  County of New York or in the
United States  District Court for the Southern  District of New York, (ii) waive
any  objection  which the Holder or the Company may have now or hereafter  based
upon  forum  non  conveniens  or to  the  venue  of any  such  suit,  action  or
proceeding,  and (iii) irrevocably  consents to the jurisdiction of the New York
State Supreme Court, County of New York and the United States District Court for
the Southern  District of New York in any such suit,  action or proceeding.  The
Holder and the Company  further agree to accept and  acknowledge  service of any
and all process  which may be served in any such suit,  action or  proceeding in
the New York State  Supreme  Court,  County of New York or in the United  States
District  Court for the Southern  District of New York and agree that service of
process upon the Company,  mailed by certified  mail to the  Company's  address,
will be deemed in every  respect  effective  service  of  process,  in any suit,
action or proceeding.  FURTHER, THE HOLDER AND THE COMPANY HEREBY WAIVE TRIAL BY
JURY IN ANY  ACTION TO ENFORCE  THIS NOTE AND IN  CONNECTION  WITH ANY  DEFENSE,
COUNTERCLAIM OR CROSS CLAIM ASSERTED IN ANY SUCH ACTION.

                                       7
<PAGE>

      (i) No recourse  shall be had for the payment of the principal or interest
of this Note against any incorporator or any past, present or future stockholder
officer,  director,  agent  or  attorney  of the  Company,  or of any  successor
corporation,   either   directly  or  through  the  Company  or  any   successor
corporation,  otherwise, all such liability of the incorporators,  stockholders,
officers, directors, attorneys and agents being waived, released and surrendered
by the Holder hereof by the acceptance of this Note.

      (j) This Note shall bind the Company and its successors and assigns.

        THIS SPACE INTENTIONALLY LEFT BLANK; SIGNATURE PAGE FOLLOWS

                                       8
<PAGE>

IN WITNESS  WHEREOF,  the  undersigned  has duly executed and delivered this 10%
Secured Convertible Promissory Note as of the day and year first above written.

                                       APPLIED DNA SCIENCES, INC.

                                       By:
                                          --------------------------------------
                                       Name:  James Hayward
                                       Title: Chief Executive Officer

                                       9

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