Document:

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                                                                    EXHIBIT 10.1

                               SERIES C-1 AND C-2
                 PREFERRED STOCK AND WARRANT PURCHASE AGREEMENT

     This Series C-1 and C-2 Preferred Stock and Warrant Purchase Agreement (the
"Agreement") is made as of May 23, 2003, by and between Genaera Corporation, a
Delaware corporation with its principal place of business located at 5110 Campus
Drive, Plymouth Meeting, Pennsylvania 19462 (the "Company"), and the parties
listed on the "Schedule of Purchasers" attached hereto as Schedule 1 (each, a
"Purchaser" and collectively, the "Purchasers").

                                   WITNESSETH:

     WHEREAS, in connection herewith, the Purchasers have agreed to purchase and
the Company has agreed to sell (A) up to two thousand five hundred (2,500)
shares of the Company's Series C-1 Convertible Preferred Stock, par value $.001
per share, (B) up to two thousand five hundred (2,500) shares of the Company's
Series C-2 Convertible Preferred Stock, par value $.001 per share, and (C)
Warrants (as defined below) to purchase up to 2,000,000 shares of Common Stock
(as defined below), on the terms and conditions set forth herein.

     NOW, THEREFORE, in consideration of the foregoing recitals and for other
good and valuable consideration, the adequacy of which is hereby affirmed, the
parties, intending to be legally bound, hereby agree as follows.

     1.  Authorization and Issuance.

         1.1  Authorization of Shares and Warrants. Subject to the terms and
conditions of this Agreement, the Company has authorized the sale and issuance
of (i) up to two thousand five hundred (2,500) shares (the "Series C-1 Shares")
of its Series C-1 Convertible Preferred Stock, par value $.001 per share (the
"Series C-1 Preferred Stock"), having the rights, preferences, privileges and
restrictions set forth in the Series C-1 Certificate of Designations,
Preferences and Rights of Series C-1 Preferred Stock in substantially the form
attached hereto as Exhibit A (the "C-1 Certificate of Designations"), (ii) up to
two thousand five hundred (2,500) shares (the "Series C-2 Shares" and
collectively with the Series C-1 Shares, the "Shares") of its Series C-2
Convertible Preferred Stock, par value $.001 per share (the "Series C-2
Preferred Stock" and together with the Series C-1 Preferred Stock, the "Series C
Preferred Stock"), having the rights, preferences, privileges and restrictions
set forth in the Series C-2 Certificate of Designations, Preferences and Rights
of Series C-2 Preferred Stock in substantially the form attached hereto as
Exhibit B (the "C-2 Certificate of Designations" and together with the C-1
Certificate of Designations, the "Certificates of Designations"), (iii) warrants
in substantially the form attached hereto as Exhibit C to purchase up to
1,500,000 shares of Common Stock upon exercise ("May Warrants"), and (iv)
warrants in substantially the form attached hereto as Exhibit D to purchase up
to 500,000 shares of Common Stock upon exercise ("November Warrants" and
together with the May Warrants, the "Warrants").

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         1.2  Issuance and Purchase of Shares and Warrants. Subject to the terms
and conditions hereof, the Company will sell to the Purchasers, severally and
not jointly, and the Purchasers will buy from the Company in the amounts
specified on Schedule A hereto, severally and not jointly, up to (a) two
thousand five hundred (2,500) Series C-1 Shares , (b) two thousand five hundred
(2,500) Series C-2 Shares, (c) May Warrants to purchase 1,500,000 shares of
Common Stock at an exercise price of $1.37 per share of Common Stock, subject to
adjustments as set forth therein, and (d) November Warrants to purchase 500,000
shares of Common Stock at an exercise price of $1.37 per share of Common Stock,
subject to adjustments as set forth therein. In consideration for the Shares and
Warrants the Purchasers shall pay the Company in United States dollars the
aggregate purchase price of up to five million dollars ($5,000,000) in the
amounts as specified on Schedule 1. Schedule 1 sets forth the number of Shares
and Warrants each Purchaser shall purchase and the Company shall sell. The
Company's agreements with each of the Purchasers are separate agreements, and
the sales to each of the Purchasers are separate sales.

     2.  The Closing. The completion of the purchase and sale of the Shares and
Warrants (the "Closing") shall occur immediately following the satisfaction of
all of the conditions precedent in Sections 3.1 and 3.2 herein, at the offices
of Dechert LLP, 1717 Arch Street, Philadelphia, Pennsylvania 19103, or such
other time or place as may be agreed upon by the Company and the Purchasers (the
"Closing Date"). At the Closing, the Company shall deliver to the Purchasers one
or more stock certificates for the Shares and Warrants, registered in the
Purchasers' name, representing their respective number of Shares and Warrants to
be purchased by the Purchasers against payment of the purchase price therefor,
by wire transfer in immediately available funds, per the Company's instructions.

     3.  Conditions to Closing.

         3.1  Obligation of Purchasers. The obligation of the Purchasers to
purchase and pay for the Shares and Warrants at the Closing is subject to the
satisfaction as of the Closing of the following conditions, any one or more of
which may be waived in writing by the Purchasers:

              (i)   (A) the accuracy in all material respects of the
         representations and warranties made by the Company herein that are not
         qualified by materiality, (B) the accuracy in all respects of the
         representations and warranties made by the Company herein that are
         qualified by materiality, and (C) the fulfillment in all material
         respects of those undertakings of the Company to be fulfilled prior to
         the Closing;

              (ii)  the purchase of the Shares and Warrants by the Purchasers
         hereunder shall not be prohibited by any applicable law or
         governmental rule or regulation;

              (iii) the Certificates of Designations shall have been filed in
         the office of the Secretary of State of the State of Delaware;

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              (iv)  the Company shall have caused the delivery to the Purchasers
         of stock certificates representing each Purchaser's ownership of the
         Shares (the "Series C-1 and C-2 Certificates") and Warrants set forth
         on Schedule 1;

              (v)   the Purchasers shall have received from Dechert LLP, counsel
         to the Company, an opinion addressed to the Purchasers in a form
         reasonably acceptable to Purchaser's counsel; and

              (vi)  the Company shall have obtained all necessary "Blue Sky" law
         permits and qualifications, or have available exemptions therefrom,
         required by any state for the offer and sale of the Shares and Warrants
         and the underlying Conversion Shares.

         3.2  Obligation of Company. The Company's obligation to complete the
purchase and sale of the Shares and Warrants and deliver the Series C-1 and C-2
Certificates and Warrants to the Purchasers at the Closing shall be subject to
the following conditions, any one or more of which may be waived in writing by
the Company:

              (i)   receipt by the Company by wire transfer in immediately
         available funds in the amount representing the full amount of the
         purchase price for the Shares and Warrants being purchased by such
         Purchaser set forth on Schedule 1;

              (ii)  (A) the accuracy in all material respects of the
         representations and warranties made by the Purchasers which are not
         qualified by materiality, (B) the accuracy in all respects of the
         representations and warranties made by the Purchasers which are
         qualified by materiality, and (C) the fulfillment in all material
         respects of those undertakings of the Purchasers to be fulfilled prior
         to the Closing; and

              (iii) the Company shall have obtained all necessary "Blue Sky" law
         permits and qualifications, or have available exemptions therefrom,
         required by any state for the offer and sale of the Shares and Warrants
         and the underlying Conversion Shares.

     4.  Representations and Warranties of the Company. Except as set forth on
Schedule 2 attached hereto, the Company represents and warrants to the
Purchasers as of the date hereof as follows:

         4.1  Organization and Standing. The Company has been duly incorporated
and is validly existing as a corporation in good standing under the laws of the
State of Delaware and has all requisite corporate power and authority to conduct
its business as described in the Company's Annual Report on Form 10-K for the
year ended December 31, 2002 filed with the Securities and Exchange Commission
(the "SEC"). The Company is qualified to do business as a foreign corporation in
the Commonwealth of Pennsylvania and there are no other jurisdictions in which
its ownership or lease of property or conduct of its business requires such
qualification, except where the failure to be so organized or in good standing
would not be reasonably likely to have a material adverse effect on the
business, financial condition or results of operations of the Company.

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         4.2  Authorized and Issued Capital Stock. The authorized capital stock
of the Company, upon the filing of the Certificates of Designations, will
consist of (i) 75,000,000 shares of Common Stock, of which 35,666,491 shares are
issued and outstanding as of the date hereof, and (ii) 9,211,031 shares of
preferred stock, $.001 par value per share (the "Preferred Stock"), of which (a)
80,000 shares have been designated "Series A Convertible Preferred Stock," and
of which 888 shares of Series A Convertible Preferred Stock are issued and
outstanding as of the date hereof and the Closing Date (b) 10,000 shares have
been designated "Series B Convertible Preferred Stock," and all of which shares
of Series B Convertible Preferred Stock are issued and outstanding as of the
date hereof, (c) 2,500 shares have been designated "Series C-1 Convertible
Preferred Stock," and (d) 2,500 shares have been designated "Series C-2
Convertible Preferred Stock". The Series C Preferred Stock shall have the
rights, preferences, privileges and restrictions set forth in the Certificates
of Designations. Immediately prior to the Closing, there are no outstanding
shares of Series C Preferred Stock. All of the outstanding shares of Common
Stock and Preferred Stock were duly authorized and validly issued and are fully
paid and non-assessable shares. The Company has reserved 5,000 shares of Series
C Preferred Stock for issuance hereunder, and 7,000,000 shares of Common Stock
for issuance upon conversion of the Series C Preferred Stock and the exercise of
the Warrants (collectively, the "Conversion Shares"). Except as disclosed in the
SEC Documents (as defined below), there are no options, warrants or other rights
to purchase or acquire any of the Company's authorized and unissued capital
stock.

         4.3  Due Authorization, Execution, Delivery and Performance of the
Agreement. The execution, delivery and performance of the Agreement by the
Company, including, but not limited to, the issuance and sale of the Shares and
Warrants and the issuance of the Conversion Shares in accordance with the
provisions of the Certificates of Designations, (i) have been duly authorized by
all requisite corporate action by the Company, including by its directors and
shareholders to the extent required under the Delaware General Corporation Law
and applicable Nasdaq rules, and (ii) will not violate (a) any law or the
Certificate of Incorporation, as amended (the "Certificate of Incorporation") or
the Amended and Restated Bylaws (the "Bylaws") of the Company, or (b) any
provision of any indenture, mortgage, agreement, contract or other instrument to
which the Company is a party or by which the Company or any of its properties or
assets is bound as of the date hereof, or result in a breach of or constitute
(upon notice or lapse of time or both) a default under any such indenture,
mortgage, agreement, contract or other instrument or result in the creation or
imposition of any lien, security interest, mortgage, pledge, charge or other
encumbrance upon any properties or assets of the Company, except where any such
breach, default, lien or encumbrance would not be reasonably likely to have a
material adverse effect on the business, financial condition or results of
operations of the Company. The Company has no subsidiaries and does not own or
control any equity interest in any corporation, association or other business
entity. Upon their execution and delivery, and assuming the valid execution
thereof by the Purchasers, the Agreement will constitute a valid and binding
obligation of the Company, enforceable against the Company in accordance with
its terms, except as enforceability may be limited by applicable bankruptcy,
insolvency, reorganization, moratorium or similar laws affecting creditors' and
contracting parties' rights generally and except as enforceability may be
subject to general principles of equity (regardless of whether such
enforceability is considered in a proceeding in equity or at law) and except as
the indemnification and contribution agreements of the Company in Section 6.3
hereof may be legally unenforceable.

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         4.4  Issuance, Sale and Delivery of the Shares and Warrants and the
Conversion Shares. When issued and paid for, the Shares and Warrants to be sold
hereunder by the Company will be validly issued and outstanding, fully paid and
non-assessable, free and clear of any liens, charges, claims or other
encumbrances. When issued in compliance with the provisions of the Certificate
of Designation, the Conversion Shares will be validly issued and outstanding,
fully paid and non-assessable, free and clear of any liens, charges, claims or
other encumbrances. The Shares and Warrants and the Conversion Shares shall not
entitle the holders of the outstanding capital stock of the Company to
preemptive, anti-dilutive or other rights to subscribe to or acquire Common
Stock or other securities of the Company; provided, however, that the Shares and
Warrants and the Conversion Shares will be subject to restrictions on transfer
under state and/or federal securities laws and restrictions set forth in Section
6 hereof.

         4.5  Exemption from Registration. Assuming the accuracy of the
Purchasers' representations and warranties set forth in Section 5 hereof, the
offer, issuance and sale of the Shares, Warrants and Conversion Shares pursuant
to this Agreement and the issuance of the Conversion Shares upon conversion of
the Shares or exercise of the Warrants, respectively, will be exempt from the
registration and prospectus delivery requirements of the Securities Act of 1933,
as amended (together with the rules and regulations promulgated thereunder, the
"Securities Act" or "Act").

         4.6  Intellectual Property. The Company has title and ownership of, or
rights to use, all patents, trademarks, service marks, trade names, copyrights,
trade secrets, information, proprietary rights and processes necessary for its
business as now conducted without any conflict with or infringement of the
rights of others, except as would not have a material adverse effect on the
Company. The Company is not bound by or a party to any material options,
licenses or agreements of any kind with respect to the patents, trademarks,
service marks, trade names, copyrights, trade secrets, licenses, information,
proprietary rights and processes of any other person or entity. Except as
disclosed in the SEC Documents, the Company has not received any communications
alleging that the Company has violated or, by conducting its business as
proposed, would violate any of the patents, trademarks, service marks, trade
names, copyrights or trade proprietary rights of any other person or entity. To
the best knowledge of the Company, no other person or entity is infringing or
violating any of the patents, trademarks, service marks, trade names,
copyrights, trade secrets, information, proprietary rights and processes
necessary for the Company's business as now conducted. To the best knowledge of
the Company, none of its employees is obligated under any contract (including
licenses, covenants or commitments of any nature) or other agreement, or subject
to any judgment, decree or order of any court or administrative agency, that
would interfere with the use of his or her best efforts to promote the interests
of the Company or that would conflict with the Company's business as proposed to
be conducted. Neither the execution nor delivery of this Agreement, nor the
carrying on of the Company's business by the employees of the Company, nor the
conduct of the Company's business as proposed, will, to the best of the
Company's knowledge, conflict with or result in a breach of the terms,
conditions or provisions of, or constitute a default under, any contract,
covenant or instrument under which the Company or any of such employees is now
obligated. The Company does not believe it is or will be necessary to utilize
any inventions of any of its employees (or people it currently intends to hire)
made prior to their employment by the Company.

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         4.7  Litigation. There are no actions, suits, proceedings or
investigations pending or, to the Company's knowledge, threatened against the
Company or its properties before any court or governmental agency which the
Company's management believes is likely to have a material adverse effect on the
Company or its prospects. The foregoing includes, without limitation, actions
pending or, to the Company's knowledge, threatened involving governmental
entities, the prior employment of any of the Company's employees, their use in
connection with the Company's business of any information or techniques
allegedly proprietary to any of their former employers, or their obligations
under any agreements with prior employers. The Company is not a party or subject
to any SEC investigation (formal or informal, to the extent the SEC has notified
the Company of such investigation) or the provisions of any order, writ,
injunction, judgment or decree of any court or government agency or
instrumentality. There is no action, suit, proceeding or investigation by the
Company currently pending or which the Company intends to initiate.

         4.8  Material Agreements. All of the contracts and agreements to which
the Company is a party and which are in effect as of December 31, 2002 and which
the Company considers to be material are listed as exhibits to the Company's
Form 10-K for the period ended December 31, 2002. Any contracts and agreements
to which the Company became a party between January 1, 2003 and the date hereof
and which the Company considers to be material are set forth on Schedule 2
hereto. All such contracts and agreements are valid, binding and in full force
and effect in all material respects, subject to laws of general application
relating to bankruptcy, insolvency and the relief of debtors and rules of law
governing specific performance, injunctive relief or other equitable remedies,
and the Company has not received any written indication of an intention to
terminate any such contract or agreement by any of the parties to any such
contract or agreement.

         4.9  Additional Information. The Company represents and warrants that
the information contained in the following documents (the "SEC Documents"),
copies of which have been furnished to the Purchasers, was true and correct in
all material respects and did not contain any untrue statement of a material
fact or omit to state any material fact necessary to make the statements
contained therein in light of the circumstances under which they were made, not
misleading as of their respective dates:

              (i)   the Company's 2002 annual report to stockholders;

              (ii)  the Company's annual report on Form 10-K for the year ended
         December 31, 2002 (without exhibits);

              (iii) the notice of annual meeting of stockholders and proxy
         statement for the Company's 2003 annual meeting of stockholders held on
         May 15, 2003;

              (iv)  the Company's quarterly report on Form 10-Q for the first
         quarter ended March 31, 2003 (without exhibits); and

              (v)   all other documents, if any, filed by the Company with the
         SEC since December 31, 2002, pursuant to the reporting requirements of
         the Exchange Act (as defined below).

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As of its filing date, each SEC Document complied as to form in all material
respects with the applicable requirements of the Securities Act and the Exchange
Act, as the case may be. As of the date hereof and the Closing, since December
31, 2002, the Company has filed with the SEC all reports which it is required to
file and amended any existing reports as required under applicable SEC rules and
regulations under the Exchange Act.

         4.10 Financial Statements. The audited financial statements and
unaudited interim financial statements of the Company included in the SEC
Documents fairly present, in all material respects the financial position of the
Company as of the dates thereof and its results of operations and cash flows for
the periods then ended (subject to normal year-end adjustments and to the
omission of certain footnotes required by GAAP in the case of any unaudited
interim financial statements). The Company has no liabilities or obligations,
absolute or contingent, that are required by GAAP or SEC rules to be set forth
in such financials, that have not been so set forth.

         4.11 Compliance with Other Instruments, None Burdensome, Etc. The
Company is not in violation of: (i) any term of its Certificate of
Incorporation, or its Bylaws; (ii) in any material respect, any term or
provision of any mortgage, indebtedness, indenture, contract, agreement,
instrument, judgment or decree; and (iii) to the best of its knowledge, any
order, statute, rule or regulation applicable to the Company except for such
violations that would not, individually or in the aggregate, have a material
adverse effect on the Company. The execution, delivery and performance of and
compliance with this Agreement, and the issuance of the Shares and Warrants and
the Conversion Shares, have not resulted and will not result in any violation
of, or conflict with, or constitute a default under, the Company's Certificate
of Incorporation or its Bylaws, and have not and will not result in any material
violation of, or conflict with, or constitute a material default under, any of
its agreements nor result in the creation of any mortgage, pledge, lien,
encumbrance or charge upon any of the properties or assets of the Company.

         4.12 Governmental Regulations, Etc. Except as required pursuant to the
Securities Act, the Securities Exchange Act of 1934, as amended (the "Exchange
Act"), and state securities laws, the Company is not subject to any federal or
state law or regulation limiting its ability to execute and deliver this
Agreement, or to offer, sell or issue the Shares, Warrants or the Conversion
Shares, or to consummate any other transaction contemplated hereby, other than
(i) the filing of the Certificates of Designations in the office of the
Secretary of State of the State of Delaware prior to the Closing and (ii) the
qualification (or taking of such action as may be necessary to secure an
exemption from qualification, if available) of the offer and sale of the Shares
and Warrants and the Conversion Shares under applicable "Blue Sky" laws, which
filings and qualifications, if required, will be accomplished in a timely
manner.

         4.13 No Material Change. Except as specifically set forth in this
Agreement or in the SEC Documents, as of the date hereof since December 31,
2002: (a) the Company has not entered into any transaction that was not in the
ordinary course of business; (b) there has been no material adverse change in
the condition (financial or otherwise) of the business, prospects, property,
assets or liabilities of the Company; (c) there has been no damage to,
destruction of or loss of physical property (whether or not covered by
insurance) materially and adversely affecting the assets, financial condition,
operating results, prospects, business or operations of the

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Company; (d) the Company has not declared or paid any dividend or made any
distribution on its stock, or redeemed or purchased or otherwise acquired any of
its stock or incurred any material tax liability; (e) the Company has not
changed any compensation arrangement or agreement with any of its key employees
or executive officers, or changed the rate of pay of its employees as a group,
other than in the ordinary course of business; (f) the Company has not received
notice that there has been a loss of a material customer of the Company; (g) the
Company has not changed or amended any contract by which the Company or any of
its assets are bound or subject that would have a material adverse effect on the
Company; (h) there has been no resignation or termination of employment of any
officer or key employee of the Company, and the Company does not know of any
impending resignation or termination of employment of any such officer or key
employee that if consummated would have a material adverse effect on the
Company; (i) there has been no labor dispute involving the Company or any of its
employees and, to the knowledge of the Company, none is pending or threatened;
(j) there has been no material and adverse change in the contingent obligations
of the Company (nor in any material contingent obligation of the Company
regarding any director, stockholder or key employee or officer of the Company)
by way of guaranty, endorsement, indemnity, warranty or otherwise; (k) there
have been no loans or guarantees in excess of $15,000 made by the Company to any
of its employees, officers or directors other than travel advances and other
advances made in the ordinary course of business; (l) there has been no waiver
by the Company of a valuable right or of a debt owing to the Company that would
have a material adverse effect on the Company; (m) there has not been any
satisfaction or discharge of any material lien, claim or encumbrance or any
payment of any material obligation by the Company except in the ordinary course
of business and that is not material to the assets, properties, financial
condition, operating results or business of the Company; (n) the Company has not
sold or transferred any patent, service mark, trade name, copyright, trade
secret or proprietary right necessary for its business; and (o) there has been
no other event or condition of any character that would have a material adverse
effect on the Company.

         4.14 Listing of Common Stock. The Conversion Shares will, upon
issuance, be listed on the Nasdaq Small Cap Market.

         4.15 Disclosure. No representation or warranty made by the Company in
this Agreement, any schedule or exhibit hereto, or any certificate delivered
hereunder, when taken together, contains any untrue statement of a material
fact, or omits to state a material fact necessary to make the statements
contained herein or therein not misleading in light of the circumstances under
which they were made.

     5.  Representations and Warranties of the Purchasers.

         5.1  The Purchasers, severally and not jointly, each represent and
warrant to, and covenant with, the Company that: (i) each Purchaser, taking into
account the personnel and resources each can practically bring to bear on the
purchase of the Shares and Warrants contemplated hereby, is knowledgeable,
sophisticated and experienced in making, and is qualified to make, decisions
with respect to investments in equity securities presenting an investment
decision like that involved in the purchase of the Shares and Warrants,
including investments in equity securities issued by early-stage biotechnology
companies such as the Company; (ii) each Purchaser or each of their counsel,
accountants or other investment advisors

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have requested, received, reviewed and considered (or the Company has made
available to them) all information requested by them in connection with the
Purchasers' decision to purchase the Shares and Warrants; (iii) each Purchaser
is acquiring the Shares and Warrants for its own account, for investment only
and with no present intention of distributing any of the Shares and Warrants in
violation of the Securities Act, and there is no arrangement or understanding
with any other persons regarding the distribution of such Shares and Warrants in
violation of the Securities Act; (iv) each Purchaser will complete or cause to
be completed promptly, and in any event within 7 days of the date hereof, the
Registration Statement Questionnaire, attached hereto as Appendix I, for use in
preparation of a Registration Statement (as defined below) and the answers
thereto will be true, correct and complete in all material respects as of the
date completed and will be true, correct and complete in all material respects
as of the effective date of a Registration Statement; (v) each Purchaser has, in
connection with its decision to purchase the Shares and Warrants, relied solely
upon the SEC Documents and the representations and warranties of the Company
contained herein, as well as any investigation of the Company completed by the
Purchasers or their counsel, accountants or other investment advisers; (vi) each
Purchaser is an "accredited investor" within the meaning of Rule 501 of
Regulation D promulgated under the Securities Act; (vii) the addresses of the
Purchasers set forth on the preamble hereto is the Purchasers' principal
business address, upon which the Company may rely for the purpose of complying
with applicable "Blue Sky" laws; and (viii) each Purchaser is able to bear the
economic risk of an investment in the Shares and Warrants.

         5.2  The Purchasers will not, directly or indirectly, offer, sell,
pledge, transfer or otherwise dispose of (or solicit any offers to buy, purchase
or otherwise acquire or take a pledge of) any of the Shares, the Warrants or the
Conversion Shares, except in compliance with the Securities Act, and the rules
and regulations promulgated thereunder and by the provisions of Section 6
hereof. Prior to conversion or exercise, as the case may be, of all the Shares
and Warrants into the Conversion Shares in accordance with the Certificates of
Designations, each Purchasers represent that it will not have any short
positions in the Company's Common Stock and will not deliver Conversion Shares
to cover any short positions taken prior to such conversion or exercise, as the
case may be, of all the Shares and Warrants. Each Purchaser hereby covenants not
to make any sale of the Conversion Shares under a Registration Statement without
effectively causing the prospectus delivery requirement under the Securities Act
to be satisfied, and each Purchaser acknowledges and agrees that such Conversion
Shares that are to be resold by any of the Purchasers pursuant to a Registration
Statement are not transferable on the books of the Company unless the
certificate submitted to the transfer agent evidencing the Conversion Shares is
accompanied by a separate officer's certificate (i) in the form of Appendix II
hereto, (ii) executed by an officer of each of the Purchasers or by an
authorized person designated by such Purchaser (which certificate shall not be
unreasonably withheld), and (iii) to the effect that the Conversion Shares have
been sold pursuant to and in accordance with the Registration Statement and the
requirement of delivering a current prospectus are being satisfied. Each
Purchaser acknowledges that there occasionally may be times when the Company
must, in good faith, and subject to the limitations set forth below in this
Section 5.2 and in Section 6.1(viii)(F) herein, suspend the use of the
prospectus forming a part of a Registration Statement until such time as an
amendment to such Registration Statement has been filed by the Company and
declared effective by the SEC, or until such time as the Company has filed an
appropriate report with the SEC pursuant to the Exchange Act; however in all
such cases the Company shall use its commercially reasonable efforts to file all
amendments and reports necessary for the

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effectiveness of the Registration Statement. Each Purchaser hereby covenants
that it will not sell any Conversion Shares pursuant to said prospectus during
the period commencing at the time at which the Company gives the Purchasers
notice of the suspension of the use of said prospectus and ending at the time
the Company gives the Purchasers notice that the Purchasers may thereafter
effect sales pursuant to said prospectus. The Company shall only be able to
suspend the use of said prospectus for two periods aggregating no more than
ninety (90) business days in any twelve-month period, of which no individual
period shall be longer than forty-five (45) consecutive days; provided, however,
that in no event shall the aggregate number of days pursuant to which the
Company may suspend the use of a prospectus pursuant to this Section 5.2 and
delay an underwritten public offering pursuant to Section 6.1(viii)(F) herein
exceed ninety (90) days in any twelve-month period. Each Purchaser further
covenants to notify promptly the Company of the sale of all of its Conversion
Shares.

         5.3  Each Purchaser understands that although there currently is a
public market for its Common Stock, Rule 144 promulgated under the Act ("Rule
144") requires, among other conditions, a one-year holding period prior to the
resale (in limited amounts) of securities acquired in a non-public offering
without having to satisfy the registration requirements under the Act. Each
Purchaser, severally, understands and hereby acknowledges that the Company is
under no obligation to register the Shares, the Warrants or the Conversion
Shares under the Act or any state securities or "Blue Sky" laws other than as
set forth in Section 6 hereof. Each Purchaser, severally, agrees to hold the
Company and its directors, officers, employees, controlling persons and agents
and their respective heirs, representatives, successors and assigns harmless and
to indemnify them against all liabilities, costs and expenses incurred by them
as a result of (i) any misrepresentation made by said Purchaser contained in
this Agreement (including Appendix I and Appendix II herein), (ii) any sale or
distribution by said Purchaser in violation of the Act or any applicable state
securities or "Blue Sky" laws or (iii) any untrue statement of a material fact
made by said Purchaser and contained herein.

         5.4  Each Purchaser hereby consents to and understands that the Shares
shall bear a restrictive legend in substantially the following form (and a
stop-transfer order may be placed against transfer of the certificates for such
securities):

              "The Shares represented by this certificate have been acquired for
              investment and have not been registered under the Securities Act
              of 1933. The Shares may not be sold or transferred in the absence
              of such registration or exemption therefrom.

              The Shares represented by this certificate and the rights of
              holders thereof are subject to certain restrictions on transfer
              and other restrictions, and the holder of the Shares represented
              by this certificate (including any holders) are bound by the terms
              of restrictions set forth in the Preferred Stock Purchase
              Agreement between the original Purchaser and the Company (copies
              of which may be obtained from the Company)."

         5.5  Each Purchaser, severally, further represents and warrants to, and
covenants with, the Company that (i) such Purchaser has full right, power,
authority and capacity

<PAGE>

to enter into the Agreement and to consummate the transactions contemplated
hereby and has taken all necessary action to authorize the execution, delivery
and performance of the Agreement, and (ii) upon the execution and delivery of
the Agreement, the Agreement shall constitute a valid and binding obligation of
such Purchaser enforceable in accordance with its terms, except as
enforceability may be limited by applicable bankruptcy, insolvency,
reorganization, moratorium or similar laws affecting creditors' and contracting
parties' rights generally and except as enforceability may be subject to general
principles of equity (regardless of whether such enforceability is considered in
a proceeding in equity or at law).

         5.6  No representation or warranty made by each Purchaser in this
Agreement, any schedule or exhibit hereto, or any certificate delivered
hereunder, when taken together, contains any untrue statement of a material
fact, or omits to state a material fact necessary to make the statements
contained herein or therein not misleading in light of the circumstances under
which they were made.

     6.  Registration of Shares.

         6.1  Registration Procedures and Expenses.

              (i)   The Company shall as soon as practicable, but in no event
         later than June 30, 2003, prepare and file with the SEC a Registration
         Statement on such form deemed appropriate for the registration of the
         Common Stock by the SEC) (the "Initial Registration Statement") to
         register up to seven million (7,000,000) shares of the Conversion
         Shares for resale by the Purchasers ("Registrable Securities") and such
         Initial Registration Statement shall include the Plan of Distribution
         section set forth in Appendix I hereof or such other Plan of
         Distribution reasonably acceptable to the Company and Purchasers, and
         shall use commercially reasonable efforts to cause the Initial
         Registration Statement to become effective as soon as practicable
         thereafter; provided that the Company shall be obligated to include in
         the Initial Registration Statement or the Subsequent Registration
         Statement (as defined herein), as the case may be, the disposition of
         Conversion Shares held by a Record Transferee (as defined herein) only
         if the Purchaser transferring any Conversion Shares to a third party
         (the "Record Transferee") gives notice of such transfer to the Company
         and any such Record Transferee agrees in writing to be bound by the
         provisions of Section 7 hereof and this Section 6; if the Purchaser
         converts the Shares at any time as permitted or exercises the Warrants
         at any time as permitted, into Conversion Shares, and the number of
         such Conversion Shares is in excess of seven million (7,000,000)
         Conversion Shares, the Company shall as soon as practicable following
         such conversion prepare and file with the SEC a second Registration
         Statement to register such excess Conversion Shares for resale by the
         Purchasers (the "Subsequent Registration Statement," together with the
         Initial Registration Statement, the "Registration Statements" and,
         individually, a "Registration Statement"), and shall use commercially
         reasonable efforts to cause the Subsequent Registration Statement to
         become effective as soon as practicable thereafter;

<PAGE>

              (ii)  The Company shall promptly prepare and file with the SEC
         such amendments and supplements to a Registration Statement and the
         prospectus used in connection therewith as may be necessary to comply
         with the Act and keep such Registration Statement effective until such
         date when either all of the Registrable Securities have been sold
         pursuant thereto or, by reason of Rule 144(k) of the SEC under the
         Securities Act or any other rule of similar effect, the Registrable
         Securities are no longer required to be registered for the sale thereof
         by the Purchasers in ordinary market transactions without imposition of
         any volume, manner of sale or other limitations (the "Registration
         Period");

              (iii) The Company shall promptly furnish to the Purchasers such
         number of preliminary and final copies of prospectuses in conformity
         with the requirements of the Securities Act and such other documents as
         the Purchasers may reasonably request, in order to facilitate the
         public sale or other disposition of all or any of the Registrable
         Securities by the Purchasers;

              (iv)  The Company shall promptly file documents required of the
         Company for normal "Blue Sky" clearance for the disposition by the
         Purchasers and any Record Transferees of the Registrable Securities in
         such states as the Purchasers may reasonably request in writing to the
         Company, provided, however, that the Company shall not be required (i)
         to qualify to do business or consent to service of process in any
         jurisdiction in which it is not now so qualified or has not so
         consented (unless the Company is already subject to service in such
         jurisdiction); (ii) provide any undertakings that cause the Company
         undue expense or burden; or (iii) make any change in its Certificate of
         Formation or Bylaws, except as may be required by the Act;

              (v)   The Company shall promptly inform the Purchasers when any
         stop order has been issued with respect to a Registration Statement and
         use commercially reasonable efforts to promptly cause such stop order
         to be withdrawn;

              (vi)  Except with respect to an underwritten offering as set forth
         in Section 6.1(viii) hereof, the Company shall bear all expenses in
         connection with the procedures in paragraphs (i) through (v) of this
         Section 6.1 and the registration of the Registrable Securities, other
         than fees and expenses, if any, of counsel or other advisers to the
         Purchasers or the other Purchasers and any direct expenses relating to
         the sale of the Registrable Securities by the Purchasers (including
         without limitation, broker's commissions, discounts or fees of any
         nature and transfer taxes or changes of any nature);

              (vii) A Questionnaire related to the Registration Statements to be
         completed by the Purchasers, including the Purchasers' approval of the
         "Plan of Distribution" section of the Registration Statement is
         attached as Appendix I to this Agreement. The Company may amend the
         Plan of Distribution section as necessary to comply with the
         requirements of the SEC, provided that, the Company shall send any such
         amendments to the Purchasers at least two (2)

<PAGE>

         business days prior to the filing of the Registration Statement with
         the SEC for the Purchasers' approval, which shall not be unreasonably
         withheld and, in the absence of written objection prior to filing,
         shall be deemed to be an approval by the Purchasers of such amended
         section; and

              (viii) Recognizing that an underwritten public offering of the
         Conversion Shares may be mutually beneficial to the Company and the
         Purchasers, the Company agrees that if the Purchasers determine to sell
         the Conversion Shares by means of an underwritten public offering, the
         Company agrees to cooperate with the Purchasers and the underwriter to
         effectuate an underwritten public offering, including entering into an
         underwriting agreement in usual and customary form, subject to the
         following conditions and limitations:

                     (A) the Purchasers shall only be permitted to effect the
         resale of Conversion Shares through one (1) underwritten offering;

                     (B) the underwriter selected by the Purchasers shall be
         reasonably acceptable to the Company;

                     (C) the Company shall have the ability to include shares of
         Common Stock to be sold on its behalf in the offering subject to
         approval by the underwriters; provided that, if the total amount of
         shares of Common Stock requested by the Company to be included in the
         offering exceeds the amount of securities that the underwriters
         determine is compatible with the success of the offering, then only
         such number of shares of Common Stock to be sold on the Company's
         behalf shall be included as the underwriters determine will not
         jeopardize the success of the offering;

                     (D) the registration of the Conversion Shares to be offered
         in the underwriting shall be on a Registration Statement;

                     (E) the Purchasers shall not be permitted to resell
         Conversion Shares pursuant to an underwritten offering until it has
         converted or exercised, as the case may be, all of its Shares and
         Warrants and unless such offering is for at least 50% of the aggregate
         Conversion Shares issued to the Purchasers pursuant to all of its
         conversions or exercises, as the case may be, of Shares and Warrants;

                     (F) the Company shall be permitted to delay an underwritten
         offering requested by the Purchasers once in any twelve month period
         for a period not to exceed sixty (60) days if the Board of Directors of
         the Company determines that it would be detrimental to effect such an
         underwritten offering at such time; provided, however, that in no event
         shall the aggregate number of days pursuant to which the Company may
         suspend the use of a prospectus pursuant to Section 5.2 herein and
         delay an underwritten public offering pursuant to this Section
         6.1(viii)(F) exceed ninety (90) days in any twelve-month period; and

                     (G) In connection with an underwritten offering of the
         Conversion Shares under this Section 6.1(viii), (i) the Purchasers and
         Company

<PAGE>

         agree to equally split any and all incremental accounting fees and
         expenses and printing costs attributable solely to the underwritten
         offering, (ii) the Purchasers agree to bear any and all discounts,
         concessions, commissions or other compensation to be received by the
         underwriters applicable to the sale of their Shares, and (iii) each
         party hereto agrees to bear their respective counsel and auditor fees
         and expenses.

                    (H) Furnish, on the date that Registrable Securities are
         delivered to the underwriters for sale in connection with a
         registration pursuant to this Section H, if such securities are being
         sold through underwriters, or, if such securities are not being sold
         through underwriters, on the date that the registration statement with
         respect to such securities becomes effective, (i) an opinion, dated
         such date, of the counsel representing the Company for the purposes of
         such registration, in form and substance as is customarily given to
         underwriters in an underwritten public offering, addressed to the
         underwriters, if any, and to the Holders requesting registration of
         Registrable Securities and (ii) a letter dated such date, from the
         independent certified public accountants of the Company, in form and
         substance as is customarily given by independent certified public
         accounts to underwriters in an underwritten public offering, addressed
         to the underwriters, if any, and to the Holders requesting registration
         of Registrable Securities.

                    (I) Permit a single firm or counsel designated as
         Purchasers' counsel by the holders of a majority in interest of the
         Registrable Securities to review the registration statement and all
         amendments and supplements thereto a reasonable period of time prior to
         their filing with the SEC and state authorities, and shall not file any
         document in a form to which such counsel reasonably objects.

                    (J) Cause the Company's officers, directors and independent
         certified public accounts to supply all information reasonably
         requested by a representative of any holder of Registrable Securities,
         and any attorney or accountant retained by such holder, in connection
         with such registration; provided, however, that such representatives,
         attorneys or accountants shall, at the request of the Company, enter
         into a confidentiality agreement, in form and substance reasonably
         satisfactory to the Company, prior to the release or disclosure of any
         such information.

              (ix)  Cause all Registrable Securities registered hereunder to be
         listed on each securities exchange or automated quotation system on
         which similar securities issued by the Company are then listed.

         6.2  Transfer of Shares and Warrants After Registration. Each Purchaser
agrees that it will not effect any disposition of the Shares and Warrants that
would constitute a sale within the meaning of the Securities Act except as
contemplated in a Registration Statement or as otherwise in compliance with
applicable securities laws and, to the extent required under the Act, that it
will promptly notify the Company of any material changes in the information set

<PAGE>

forth in a Registration Statement regarding the Purchasers or their plan of
distribution. The Company agrees to notify each Purchaser whose Registrable
Securities are registered on a Registration Statement and its agent at any time
when a prospectus relating to any Registrable Securities covered by such
Registration Statement is required to be delivered under the Securities Act of
the happening of any event as a result of which the prospectus included in such
registration statement, as then in effect, includes an untrue statement of a
material fact or omits to state a material fact required to be stated therein or
necessary to make the statements therein not misleading in light of the
circumstances then existing, and to promptly file such amendments and
supplements as may be necessary so that, as thereafter delivered to such
Purchasers of such Registrable Securities, such prospectus shall not include an
untrue statement of a material fact or omit to state a material fact required to
be stated therein or necessary to make the statements therein not misleading in
light of the circumstances then existing and use commercially reasonable efforts
to cause each such amendment and supplement to become effective.

         6.3  Indemnification and Contribution. For the purpose of this Section
6.3, the term "Selling Stockholder" shall include each Purchaser, its officers,
directors, and/or trustees and any affiliate or controlling person of such
Purchaser or any permitted assign hereunder; and the term "untrue statement"
shall include any untrue statement or alleged untrue statement, or any omission
or alleged omission to state in a Registration Statement a material fact
required to be stated therein or necessary to make the statements therein, in
the light of the circumstances under which they were made, not misleading and
any violation or alleged violation of the Act, the Exchange Act, any state
securities law or rules and regulations thereunder.

              (i)   The Company agrees to indemnify and hold harmless each
         Selling Stockholder from and against any losses, claims, damages or
         liabilities to which such Selling Stockholder may become subject (under
         the Securities Act or otherwise) insofar as such losses, claims,
         damages or liabilities (or actions or proceedings in respect thereof)
         arise out of, or are based upon, any breach of the representations set
         forth in Section 4 hereof by the Company, or any untrue statement of a
         material fact by the Company contained in a Registration Statement or
         otherwise, or arise out of any failure by the Company to fulfill any
         agreement, covenant or undertaking contained in this Agreement or
         included in a Registration Statement, and the Company will reimburse
         such Selling Stockholder for any legal or other expenses reasonably
         incurred in investigating, defending or preparing to defend any such
         action, proceeding or claim; provided, however, that the Company shall
         not be liable in any such case if such loss, claim, damage or liability
         arises out of, or is based upon, (i) an untrue statement made in a
         Registration Statement in reliance upon and in conformity with written
         information furnished to the Company by or on behalf of such Selling
         Stockholder specifically for use in preparation of a Registration
         Statement (which shall be deemed to include the information set forth
         in the Registration Statement Questionnaire and in the plan of
         distribution section of the prospectus), (ii) the failure of such
         Selling Stockholder to comply with the covenants and agreements
         contained herein respecting transfer or sale of the Shares and
         Warrants, including, but not limited to, each Purchaser's covenant in
         Section 5.2 hereof to comply with the prospectus delivery requirements
         under the Securities Act, or (iii) any

<PAGE>

         statement or omission in any Prospectus that is corrected in any
         subsequent Prospectus that was delivered to the Purchasers prior to the
         pertinent sale or sales by the Purchasers. The Company shall also not
         be liable for amounts paid in settlement of any loss, claim, damage or
         liability if such settlement is effected without the prior written
         consent of the Company, which consent shall not be unreasonably
         withheld or delayed.

              (ii)  Each Purchaser, severally and not jointly, agrees to
         indemnify and hold harmless the Company (and each person, if any, who
         controls the Company within the meaning of Section 15 of the Securities
         Act, each officer of the Company who signs the Registration Statement
         and each director of the Company) from and against any losses, claims,
         damages or liabilities to which the Company (or any such officer,
         director or controlling person) may become subject (under the
         Securities Act or otherwise), insofar as such losses, claims, damages
         or liabilities (or actions or proceedings in respect thereof) arise out
         of, or are based upon, any breach of the representations set forth in
         Section 5 hereof by such Purchaser, or any failure by such Purchaser to
         comply with the covenants and agreements contained herein relating to
         transfer or sale of the Shares and Warrants, including, but not limited
         to, such Purchaser's covenant in Section 5.2 hereof to comply with the
         prospectus delivery requirements under the Securities Act, or any
         untrue statement of a material fact contained in a Registration
         Statement if such untrue statement was made in reliance upon and in
         conformity with written information furnished by or on behalf of such
         Purchaser specifically for use in a Registration Statement. Each such
         Purchaser will reimburse the Company (or such officer, director or
         controlling person), as the case may be, for any legal or other
         expenses reasonably incurred in investigating, defending or preparing
         to defend any such action, proceeding or claim. Each Purchaser agrees
         that the information regarding such Purchaser or its officers,
         directors and affiliates and their intended plan of distribution of the
         Conversion Shares set forth in a Registration Statement questionnaire,
         the form of which is attached as Appendix I, or included from time to
         time in a Registration Statement (including without limitation the plan
         of distribution section of such Registration Statement) shall be deemed
         to be written information furnished to the Company by or on behalf of
         such Purchaser specifically for use in preparation of a Registration
         Statement. The foregoing indemnification shall be limited in amount to
         the aggregate purchase price paid by such Purchaser hereunder. Each
         Purchaser shall also not be liable for amounts paid in settlement of
         any loss, claim, damage or liability if such settlement is effected
         without the prior written consent of such Purchaser, which consent
         shall not be unreasonably withheld or delayed.

              (iii) Promptly after receipt by any indemnified person of a
         notice of a claim or the beginning of any action in respect of which
         indemnity is to be sought against an indemnifying person pursuant to
         this Section 6.3, such indemnified person shall notify the indemnifying
         person in writing of such claim or of the commencement of such action;
         provided, however, that any failure by an indemnified person to notify
         an indemnifying person shall not relieve the indemnifying person from
         its obligations hereunder except to the extent that the

<PAGE>

         indemnifying person is prejudiced thereby. Subject to the provisions
         hereinafter stated, in case any such action shall be brought against an
         indemnified person and such indemnifying person shall have been
         notified thereof, such indemnifying person shall be entitled to
         participate therein, and, to the extent it shall wish, to assume and
         control the defense thereof, with counsel reasonably satisfactory to
         such indemnified person. After notice from the indemnifying person to
         such indemnified person of its election to assume the defense thereof,
         such indemnifying person shall not be liable to such indemnified
         person for any legal expenses subsequently incurred by such
         indemnified person in connection with the defense thereof; provided,
         however, that if there exists a conflict of interest that would make
         it inappropriate, in the opinion of counsel to the indemnifying
         person, for the same counsel to represent both the indemnified person
         and such indemnifying person or any affiliate or associate thereof,
         the indemnified person shall be entitled to retain its own counsel at
         the expense of such indemnifying person; provided further, however,
         that no indemnifying person shall be responsible for the fees and
         expenses of more than one separate counsel for all indemnified parties
         hereunder.

              (iv)  If the indemnification provided for in this Section 6.3
         from the indemnifying person would be applicable by its terms but is
         otherwise unavailable, as determined by a court of applicable
         jurisdiction, to an indemnified person hereunder in respect of any
         losses, claims, damages, liabilities or expenses referred to herein,
         then the indemnifying person, in lieu of indemnifying such indemnified
         person, shall contribute to the amount paid or payable by such
         indemnified person as a result of such losses, claims, damages,
         liabilities or expenses in such proportion as is appropriate to reflect
         the relative fault of the indemnifying person and indemnified persons
         in connection with the actions which resulted in such losses, claims,
         damages, liabilities or expenses, as well as any other relevant
         equitable considerations. The relative fault of such indemnifying
         person and indemnified persons shall be determined by reference to,
         among other things, whether any action in question, including any
         untrue or alleged untrue statement of a material fact, has been made
         by, or relates to information supplied by, such indemnifying person or
         indemnified persons, and the parties' relative intent, knowledge,
         access to information and opportunity to correct or prevent such
         action. The amount paid or payable by a party as a result of the
         losses, claims, damages, liabilities and expenses referred to above
         shall be deemed to include, subject to the limitations set forth in
         this Section 6.3, any reasonable legal or other fees or expenses
         reasonably incurred by such party in connection with any investigation
         or proceeding.

              (v)   The parties hereto agree that it would not be just and
         equitable if contribution pursuant to this Section 6.3 were determined
         by pro rata allocation or by any other method of allocation which does
         not take account of the equitable considerations referred to in the
         immediately preceding paragraph. Notwithstanding the provisions of this
         Section 6.3, the Purchasers shall not be required to contribute any
         amount in excess of the dollar amount of the proceeds received by the
         Purchasers upon the sale of the Conversion Shares, giving rise to

<PAGE>

         such contribution obligation. No person guilty of fraudulent
         misrepresentation (within the meaning of Section 11(f) of the
         Securities Act) shall be entitled to contribution from any person who
         was not guilty of such fraudulent misrepresentation.

              (vi)  The indemnification and contribution provided in this
         Section 6.3 shall be in addition to any other rights and remedies
         available at law or in equity.

     7.  Compliance. With a view to making available to the Purchasers the
benefits of Rule 144 promulgated under the Securities Act, the Company agrees:

         7.1  so long as the Purchasers or any subsequent holder(s) of the
Shares, the Warrants or the Conversion Shares own the Shares, the Warrants or
the Conversion Shares, promptly upon request, to furnish to such owner such
information as may be reasonably necessary to cooperate with such owner to
permit such owner to sell the Conversion Shares pursuant to Rule 144 without
registration; and

         7.2  if at any time the Company is not required to file reports with
the SEC pursuant to Sections 13 or 15(d) of the Exchange Act, to use
commercially reasonable efforts to, upon the request of the Purchasers or any
subsequent holder(s) of any of the Shares, the Warrants or the Conversion
Shares, to make publicly available other information so long as is necessary to
permit publication by brokers and dealers of quotations for the Common Stock and
sales of the Conversion Shares in accordance with Rule 15c2-11 under the
Exchange Act.

     8.  Right of First Offer To Subscribe To New Issuances.

         8.1  General.

              (i)   Upon the Closing, the Company hereby grants to each of the
Purchasers the right of first offer to purchase such Purchaser's pro rata share
("Pro Rata Share") of New Securities (as defined in Section 8.1(ii)) that the
Company may, from time to time, propose to sell and issue. Such Purchaser's Pro
Rata Share, for purposes of this right of first offer, is the ratio that the
number of shares of Common Stock (assuming conversion of all Series C Preferred
Stock, the Warrants and all other securities convertible directly or indirectly
into Common Stock but not including options to acquire Common Stock) held by
such Purchaser bears to the total number of shares of Common Stock outstanding
immediately prior to the time of issuance of such New Securities (assuming
conversion into Common Stock of all outstanding Preferred Stock and any other
securities convertible directly or indirectly into Common Stock but not
including options to acquire Common Stock). This right of first offer shall be
subject to the following provisions:

              (ii)  Certain Definitions. For purposes of this Section 8.2(ii),
"New Securities" shall mean any Common Stock or any Preferred Stock of the
Company, whether or not now authorized, and any rights, options, or warrants to
purchase said Common Stock or Preferred Stock, and securities of any type
whatsoever that are, or may become, convertible into or exchangeable for Common
Stock or Preferred Stock; provided, however, that "New Securities" does not
include (i) securities issuable upon conversion of or with respect to the Series
A Preferred Stock, the Series B Preferred Stock or the Series C Preferred Stock
or upon

<PAGE>

conversion of or with respect to any other Preferred Stock subsequently issued;
(ii) securities offered to the public pursuant to a registration statement filed
under the Securities Act, provided that the Company shall use reasonable
efforts, subject to applicable law, to allow Purchasers to participate in such
offerings as if these were New Securities; (iii) securities issued pursuant to
the acquisition of another unaffiliated corporation by the Company by merger,
purchase of substantially all of the assets, or other reorganization whereby the
Company owns not less than 50% of the voting power of the surviving corporation;
(iv) shares of the Company's Common Stock (or related options or warrants)
issued to employees, officers, directors, consultants, or other persons
performing services for the Company (including, but not by way of limitation,
distributors and sales representatives) pursuant to the Company's 1992 Stock
Option Plan, 1998 Equity Compensation Plan or any other stock offering, plan, or
arrangement approved by the Board of Directors of the Company; (v) securities
issued in good faith pursuant to or in connection with any corporate
partnership, joint venture or licensing arrangement with a non-affiliate or in
connection with an unaffiliated equipment lease financing or bank debt into
which the Company may enter; (vi) shares of the Company's Common Stock or
Preferred Stock issued in connection with any stock split, stock dividend, or
recapitalization by the Company; or (vii) securities issued pursuant to rights,
options, warrants or agreements which are outstanding as of the date hereof.

              (iii) Mechanics of Right.

                    (1) Notices; Pro Rata Rights. In the event that the Company
proposes to issue New Securities, it shall give each such Purchaser written
notice (the "First Notice") of its intention, describing the type of New
Securities, the price, and the general terms upon which the Company proposes to
issue the same. Within 3 days after receipt of the First Notice, each Purchaser
shall give the Company written notice (the "Purchaser Notice") of its intention
to purchase or obtain, at the price and on the terms specified in the First
Notice, a number of shares equal to or less than its Pro Rata Share of the New
Securities. In addition, each Purchaser Notice shall state whether a Purchaser
wishes to purchase more than its Pro Rata Share of the New Securities. The
Company shall promptly give written notice to each Purchaser that purchases its
Pro Rata Share of the New Securities (a "Fully-Exercising Purchaser") of the
amount of New Securities, if any, that other Purchasers do not elect to purchase
in response to the First Notice (the "Second Notice"). Each Fully-Exercising
Purchaser shall notify the Company within 24 hours of receipt of the Second
Notice if it would like to purchase any of the unsubscribed shares and indicate
the maximum number of unsubscribed shares it would like to purchase. The Company
shall inform the Fully-Exercising Purchasers of the total number of unsubscribed
shares available and provide the Fully-Exercising Purchasers with an allocation
of the unsubscribed shares based on the number of shares of Common Stock
(assuming conversion of all Preferred Stock into Common Stock) held by each
Fully-Exercising Purchaser.

                    (2) Company Right. To the extent that Purchasers fail to
exercise in full the right of first offer as provided in Section 8.1(i)(1)
hereof, the Company shall have 120 days thereafter to sell (or enter into an
agreement pursuant to which the sale of New Securities covered thereby shall be
closed, if at all, within said 120-day period) the New Securities respecting
which the Purchasers' rights were not exercised, at a price and upon general
terms no more favorable to the purchasers thereof than specified in the
Company's notice. In the event the Company has not sold the New Securities
within said 120-day period (or sold and

<PAGE>

issued New Securities in accordance with the foregoing within 120 days from the
date of said agreement), the Company shall not thereafter issue or sell any New
Securities, without first offering such securities to the Purchasers in the
manner provided above.

                    (3) No Impairment. A Purchaser's failure to exercise this
right of first offer on any issuance of New Securities shall not adversely
affect the Purchaser's right of first offer to purchase subsequent issuances of
New Securities.

              (iv)  Termination. The rights of first offer under this Section
8.1 shall not apply to and shall terminate as to each Purchaser upon the
conversion of such Purchaser's Series C Preferred Stock into Common Stock or
redemption of such Purchaser's Series C Preferred Stock by the Company.

              (v)   Assignment. The right of first offer granted under this
Section 8.1 is nonassignable except to a successor to a Purchaser.

     9.  Miscellaneous.

         9.1  Governing Law. This Agreement shall be governed in all respects by
the laws of the Commonwealth of Pennsylvania as such laws are applied to
agreements between Pennsylvania residents entered into and performed entirely in
Pennsylvania and without regard to conflicts of law.

         9.2  Survival of Warranties. The representations and warranties of the
Company and the Purchasers contained in or made pursuant to this Agreement shall
survive until one year following the execution of this Agreement, the payment of
the aggregate purchase price and the delivery of Series C-1 and C-2 Certificates
and the Warrants.

         9.3  Successors and Assigns. The provisions hereof shall inure to the
benefit of, and be binding upon, the successors, assigns, heirs, executors and
administrators of the parties hereto (specifically including successors in
interest to the Shares and Warrants).

         9.4  Entire Agreement; Amendments. This Agreement sets forth all of the
promises, covenants, agreements, conditions and undertakings between the parties
hereto with respect to the subject matter hereof, and supersedes all prior and
contemporaneous agreements and understandings, inducements or conditions,
express or implied, oral or written, except as contained herein. This Agreement
may not be changed orally but only by an agreement in writing, duly executed by
or on behalf of the party or parties against whom enforcement of any waiver,
change, modification, consent or discharge is sought.

         9.5  Notices, Etc. All notices and other communications required or
permitted hereunder shall be effective upon receipt and shall be in writing and
may be delivered in person, by facsimile, overnight delivery service or U.S.
mail, in which event it may be mailed by first-class, certified or registered,
postage prepaid, addressed

<PAGE>

                    if to the Company, to:

                    Genaera Corporation
                    5110 Campus Drive
                    Plymouth Meeting, PA 19462
                    Attention: Roy C. Levitt, M.D.
                    Facsimile: (610) 941-5399

                    with a copy so mailed to:

                    Dechert LLP
                    1717 Arch Street
                    Philadelphia, Pennsylvania 19103
                    Attention: James A. Lebovitz
                    Facsimile: (215) 994-2222

                    if to a Purchaser, to the address(es) specified on the
signature page of this Agreement for such Purchaser, or to such other person at
such other place as the parties shall designate to the others in writing.

         9.6  Severability of this Agreement. If any provision of this Agreement
shall be judicially determined to be invalid, illegal or unenforceable, the
validity, legality and enforceable of the remaining provisions shall not in any
way be affected or impaired thereby.

         9.7  Titles and Subtitles. The titles of the paragraphs and
subparagraphs of this Agreement are for convenience of reference only and are
not to be considered in construing this Agreement.

         9.8  Costs and Attorneys' Fees. Subject to Section 6.3 of this
Agreement, in the event that any action, suit, or other proceeding is instituted
concerning or arising out of this Agreement or the Warrants, the prevailing
party shall recover all of such party's costs, and reasonable attorneys' fees
incurred by each and every such action, suit or other proceeding, including any
and all appeals or petitions therefrom.

         9.9  Counterparts. This Agreement may be executed in any number of
counterparts, each of which shall be an original, but all of which together
shall constitute one instrument.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

<PAGE>

     IN WITNESS WHEREOF, the parties have caused this Agreement to be duly
executed and delivered by their proper and duly authorized officers as of the
day and year first written above.

                                   GENAERA CORPORATION

                                   By: /s/ Roy C. Levitt
                                       -----------------
                                   Name:  Roy C. Levitt, M.D.
                                   Title: President and Chief Executive Officer

                                   Biotechnology Value Fund LP
                                   BVF Partners LP, General Partner
                                   BVF Inc., General Partners

                                   By: /s/ Mark Lampert
                                       ----------------
                                   Name:  Mark Lampert
                                   Title: President
                                   Address:

                                   Biotechnology Value Fund II LP
                                   BVF Partners LP, General Partner
                                   BVF Inc., General Partners

                                   By: /s/ Mark Lampert
                                       ----------------
                                   Name:  Mark Lampert
                                   Title: President
                                   Address:

<PAGE>

                                   Investment 10, LLC
                                   BVF Partners LP, its attorney-in-fact
                                   BVF Inc., its General Partner

                                   By: /s/ Mark Lampert
                                       ----------------
                                   Name:  Mark Lampert
                                   Title: President
                                   Address:

                                   BVF Investments LLC
                                   BVF Partners LP, Manager
                                   BVF Inc., its General Partner

                                   By: /s/ Mark Lampert
                                       ----------------
                                   Name:  Mark Lampert
                                   Title: President
                                   Address:

                                   Ziff Asset Management, L.P.
                                   By: PBK Holdings, Inc., its General Partner

                                   By: /s/ Frederick H. Fogel
                                       ----------------------
                                   Name:  Frederick H. Fogel
                                   Title: Vice President
                                   Address:<PAGE>

                                                                    EXHIBIT 10.2

                               FORM OF MAY WARRANT

THIS WARRANT HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED. IT MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE
ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THE WARRANT UNDER SUCH ACT
OR AN OPINION OF COUNSEL SATISFACTORY TO GENAERA CORPORATION THAT SUCH
REGISTRATION IS NOT REQUIRED.

                               GENAERA CORPORATION

               WARRANT FOR THE PURCHASE OF SHARES OF COMMON STOCK

No. W-[   ]                                                      [   ] Shares

         THIS CERTIFIES that, for value received, Genaera Corporation, a
Delaware corporation (the "Company"), upon the surrender of this Warrant to the
Company at the address specified herein, at any time during the Exercise Period
(as defined below) will upon receipt of the Exercise Price (as defined below),
sell and deliver to [ ] (the "Holder") up to the number of duly authorized,
validly issued and fully paid and nonassessable shares of common stock of the
Company, par value $0.002 per share, set forth above. The term "Common Stock"
shall mean the aforementioned common stock of the Company together with any
other equity securities that may be issued by the Company in connection
therewith or in substitution therefor, as provided herein, that is not limited
as to final sum or percentage in respect of the rights of the holders thereof to
participate in dividends or in distribution of assets upon the voluntary or
involuntary liquidation, dissolution or winding up of the Company. The "Exercise
Period" shall begin on May 23, 2003 and shall end on May 23, 2008. During the
Exercise Period, the Holder may purchase such number of shares of Common Stock
at a purchase price per share equal to $1.37 as appropriately adjusted pursuant
to Section H hereof (the "Exercise Price").

         The number of shares of Common Stock to be received upon the exercise
of this Warrant and the price to be paid for a share of Common Stock are subject
to adjustment from time to time as hereinafter set forth. The shares of Common
Stock deliverable upon such exercise, as adjusted from time to time, are
hereinafter sometimes referred to as "Warrant Shares."

Section A.   Exercise of Warrant. This Warrant may be exercised in whole or in
part, at any time or from time to time, during the Exercise Period by
presentation and surrender hereof to the

<PAGE>

Company at its principal office at 5110 Campus Drive, Plymouth Meeting,
Pennsylvania 19462 (or at such other address as the Company or its agent may
hereafter designate in writing to the Holder), or at the office of its warrant
agent, with the Notice of Exercise Form contained herein duly executed and
accompanied by a wire transfer of immediately available funds, cash or a
certified or official bank check drawn to the order of "Genaera Corporation" in
the amount of the Exercise Price multiplied by the number of Warrant Shares
specified in such form. If this Warrant should be exercised in part only, the
Company shall, upon surrender of this Warrant, promptly execute and deliver a
new Warrant evidencing the rights of the Holder thereof to purchase the balance
of the Warrant Shares purchasable hereunder. Upon receipt by the Company during
the Exercise Period of this Warrant and such Notice of Exercise Form, in proper
form for exercise, together with proper payment of the Exercise Price, at such
office, or by the warrant agent of the Company at its office, the Holder shall
be deemed to be the holder of record of the number of Warrant Shares specified
in such form; provided, however, that if the date of such receipt by the Company
or its agent is a date on which the stock transfer books of the Company are
closed, such person shall be deemed to have become the record holder of such
shares on, and such certificate shall be dated, the next succeeding business day
on which the stock transfer books of the Company are open. The Company shall pay
any and all documentary, stamp or similar issue or transfer taxes payable in
respect of the issue or delivery of such Warrant Shares. Any new or substitute
Warrant issued under this Section A or any other provision of this Warrant shall
be dated the date of this Warrant. Upon exercise of this Warrant, the Company or
its warrant agent shall promptly cause to be issued and shall promptly deliver
upon written order of the Holder of this Warrant, and in such name or names as
such Holder may designate, a certificate or certificates for the Warrant Shares.

               1. As an alternative means of exercising this Warrant, the holder
          hereof may elect to receive shares equal to the value of this Warrant
          (or the portion of the Warrant being cancelled) by surrender of this
          Warrant at the principal office of the Company together with notice of
          such election in which event the Company shall issue to such holder
          that number of shares of the Company's Common Stock computed using the
          following formula:

                                     Y(A - B)
                                 X = --------
                                         A

          Where:

              X:   the number of shares of Common Stock to be issued to the
                   holder hereof.

              Y:   the number of shares of Common Stock purchasable under this
                   Warrant.

              A:   the fair market value of one share of the Company's Common
                   Stock.

              B:   the Exercise Price (as adjusted to the date of such
                   calculations).

<PAGE>

              For purposes of this Section A(1), the fair market value of one
         share of the Company's Common Stock shall be based on the average of
         the closing bid and asked prices of the closing price quoted on any
         exchange on which the Common Stock is listed, as published in the
         Eastern Edition of The Wall Street Journal for the twenty (20) trading
         days immediately prior to the date of determination of fair market
         value. If the Common Stock is not traded on an exchange, the fair
         market value of the Company's Common Stock shall be determined in good
         faith by the Board of Directors of the Company and the Holder;
         provided, however, that if the Board of Directors of the Company and
         the Holder fail to agree to a fair market value of the Common Stock,
         such fair market value shall be determined by an independent
         arbitrator selected by the Company and reasonably acceptable to the
         Holder; and further provided that the costs of such independent
         arbitrator shall be borne by the party whose estimate of the fair
         market value of the Common Stock was further from the determination of
         fair market value made by such arbitrator.

         Section B.  Warrant Register. This Warrant will be registered in a
register (the "Warrant Register") to be maintained by the Company or its agent
at its principal office in the name of the recordholder to whom it has been
distributed. The Company may deem and treat the registered holder of this
Warrant as the absolute owner thereof (notwithstanding any notation of ownership
or other writing hereon made by anyone), for the purpose of any exercise thereof
or any distribution to the holder thereof and for all other purposes, and the
Company shall not be affected by any notice to the contrary.

         Section C.  Reservation of Shares. The Company hereby agrees that at
all times there shall be reserved for issuance and delivery upon exercise of
this Warrant all shares of its Common Stock or other shares of capital stock of
the Company from time to time issuable upon exercise of this Warrant. All such
shares shall be duly authorized and, when issued upon such exercise in
accordance with the terms of this Warrant, shall be validly issued, fully paid
and nonassessable, free and clear of all liens, security interests, charges and
other encumbrances or restrictions on sale and free and clear of all preemptive
rights.

         Section D.  Transfer of Warrant. This Warrant may not be transferred by
the Holder, except in its entirety to a wholly-owned subsidiary of the Holder,
to a party that acquires all or substantially all of the assets of the Holder or
to an Affiliate (as defined below). Subject to the foregoing, this Warrant shall
inure to the benefit of the successors to the Holder. This Warrant and all
rights hereunder, in whole or in part, is registrable at the office or agency of
the Company referred to above by the Holder hereof in person or by his duly
authorized attorney, upon surrender of this Warrant properly endorsed.
"Affiliate" shall mean, with respect to any Person (as defined below), any other
Person controlling, controlled by or under direct or indirect common control
with such Person (for the purposes of this definition "control," when used with
respect to any specified Person, shall mean the power to direct the management
and policies of such person, directly or indirectly, whether through ownership
of voting securities, by contract or otherwise; and the terms "controlling" and
"controlled" shall have meanings correlative to the foregoing). "Person" shall
mean any person, individual, corporation, limited liability company,

<PAGE>

partnership, trust or other non-governmental entity or any governmental agency,
court, authority or other body (whether foreign, federal, state, local or
otherwise).

         Section E.  Registration of Warrant Shares. The Warrant Shares shall
have the registration rights described in Section 6 of the Series C-1 and C-2
Preferred Stock and Warrant Purchase Agreement dated May 23, 2003 between the
Company and the Purchasers thereto and the terms of Section 6 shall be
incorporated herein by reference.

         Section F.  Lost, Mutilated or Missing Warrant. Upon receipt by the
Company of evidence reasonably satisfactory to it of the loss, theft,
destruction or mutilation of this Warrant, and (in the case of loss, theft or
destruction) of reasonably satisfactory indemnification, and upon surrender and
cancellation of this Warrant, if mutilated, the Company, at its expense, shall
execute and deliver a new Warrant of like tenor and date.

         Section G.  Rights of the Holder. Subject to applicable law, the Holder
shall not, by virtue hereof, be entitled to any rights or subject to any
obligation or liability of a shareholder in the Company, either at law or
equity, and the rights of the Holder are limited to those expressed in this
Warrant.

         Section H.  Adjustments. The Exercise Price and the number of shares
purchasable hereunder are subject to adjustment from time to time as follows:

              1.  Stock Dividend, Split or Subdivision of Shares. If the number
         of shares of Common Stock outstanding at any time after the date
         hereof is increased by a stock dividend payable to all holders of
         Common Stock in shares of Common Stock or by a subdivision or split-up
         of shares of Common Stock, then, following the record date fixed for
         the determination of holders of Common Stock entitled to receive such
         stock dividend, subdivision or split-up, the Exercise Price shall be
         appropriately decreased and the number of shares of Common Stock
         issuable on exercise of each Warrant shall be increased in proportion
         to such increase in outstanding shares.

              2.  Combination of Shares. If, at any time after the date hereof,
         the number of shares of Common Stock outstanding is decreased by a
         combination or consolidation of the outstanding shares of Common Stock,
         by reclassification, reverse stock split or otherwise, then, following
         the record date for such combination, the Exercise Price shall be
         appropriately increased and the number of shares of Common Stock
         issuable on exercise of each Warrant shall be decreased in proportion
         to such decrease in outstanding shares.

              3.  Calculations. All calculations under this Section shall be
         made to the nearest one-tenth of a cent ($.001), or to the nearest
         one-tenth of a share, as the case may be.

<PAGE>

               4.  Merger and Consolidation. If at any time there is a capital
         reorganization or reclassification of shares of Common Stock, or a
         merger or consolidation of the Company with or into another corporation
         where the Company is not the surviving corporation, or the sale of all
         or substantially all of the Company's properties and assets to any
         other person, then as part of such reorganization, merger,
         consolidation or sale, lawful provision shall be made so that the
         Holder shall thereafter be entitled to receive upon exercise of its
         rights to purchase Common Stock, the number of shares of Common Stock,
         cash, property or shares of the successor corporation resulting from
         such merger or consolidation, to which a holder of Common Stock,
         deliverable upon exercise of the rights to purchase Common Stock
         hereunder, would have been entitled in such capital reorganization,
         merger or consolidation or sale if the right to purchase such Common
         Stock hereunder had been exercised immediately prior to such capital
         reorganization, merger, consolidation or sale. In any such event,
         appropriate adjustment shall be made in the application of the
         provisions of this Warrant with respect to the rights and interests of
         the Holder after such capital reorganization, merger, consolidation or
         sale so that the provisions of this Warrant (including Exercise Price
         and the number of shares of Common Stock purchasable pursuant to the
         terms and conditions of this Warrant) shall be applicable after that
         event as near as reasonably may be, in relation to any shares
         deliverable upon the exercise of the Holder's rights to purchase Common
         Stock pursuant to this Warrant.

               5.  Certificate as to Adjustments. Upon the occurrence of each
         adjustment or readjustment pursuant to this Section H, the Company, at
         its own expense, shall promptly compute such adjustment or readjustment
         in accordance with the terms hereof and furnish to each Holder a
         certificate setting forth such adjustment or readjustment and showing
         in detail the facts upon which such adjustment or readjustment is
         based. The Company shall, upon the written request, at any time, of any
         such Holder, furnish or cause to be furnished to such Holder a like
         certificate setting forth: (a) such adjustments and readjustments; (b)
         the Exercise Price at the time in effect; and (c) the number of shares
         and the amount, if any of other property that at the time would be
         received upon the exercise of the Warrant.

         Section I.  Fractional Shares. No fractional shares of the Company's
Common Stock will be issued in connection with any purchase hereunder but in
lieu of such fractional shares the Company shall make a cash refund therefor
equal in amount to the product of the applicable fraction multiplied by the
Exercise Price paid by the Holder for one Warrant Share upon such exercise.

         Section J.  Notices of Certain Events. In the event:

               1.    the Company authorizes the issuance to all holders of its
         Common Stock of rights or warrants to subscribe for or purchase shares
         of its Common Stock or of any other subscription rights or warrants; or

<PAGE>

               2.  the Company authorizes the distribution to all holders of its
         Common Stock of evidences of its indebtedness or assets (other than
         cash dividends or distributions except extraordinary cash dividends or
         distributions); or

               3.  of any capital reorganization or reclassification of the
         Common Stock (other than a subdivision or combination of the
         outstanding Common Stock and other than a change in par value of the
         Common Stock) or of any consolidation or merger to which the Company is
         a party or of the conveyance or transfer of all or substantially all of
         the properties and assets of the Company; or

               4.  of the voluntary or involuntary dissolution, liquidation or
         winding-up of the Company; or

               5.  any other actions would require an adjustment under Section H
         hereof;

then the Company will cause to be mailed to the Holder, at least 5 days before
the applicable record or effective date hereinafter specified, a notice stating
(A) the date as of which the holders of Common Stock of record entitled to
receive any such rights, warrants or distributions are to be determined, or (B)
the date on which any such consolidation, merger, conveyance, transfer,
dissolution, liquidation or winding-up is expected to become effective, and the
date as of which it is expected that holders of Common Stock of record will be
entitled to exchange their shares of Common Stock for securities or other
property, if any, deliverable upon such reorganization, reclassification,
consolidation, merger, conveyance, transfer, dissolution, liquidation or
winding-up.

         Section K.  Listing on Securities Exchanges. The Company will list on
the Nasdaq Small Cap Market System and each national securities exchange on
which any Common Stock may at any time be listed all shares of Common Stock from
time to time issuable upon the exercise of this Warrant, subject to official
notice of issuance upon the exercise of this Warrant, and will maintain such
listing so long as any other shares of its Common Stock are so listed; and the
Company shall so list on the Nasdaq Small Cap Market System and each national
securities exchange, and shall maintain such listing of, any other shares of
capital stock of the Company issuable upon the exercise of this Warrant if and
so long as any shares of capital stock of the same class are listed on the
Nasdaq Small Cap Market System and such national securities exchange by the
Company. Any such listing will be at the Company's expense.

         Section L.  Successors. All the provisions of this Warrant by or for
the benefit of the Company shall bind and inure to the benefit of its respective
successors and assigns.

         Section M.  Headings. The headings of sections of this Warrant have
been inserted for convenience of reference only, are not to be considered a part
hereof and shall in no way modify or restrict any of the terms or provisions
hereof.

<PAGE>

         Section N. Amendments. The terms and provisions of this Warrant may not
be modified or amended, or any provisions hereof waived, temporarily or
permanently, except by written consent of the Company and the Holder hereof.

         Section O. Notices. Unless otherwise provided in this Warrant, all
notices, requests, consents and other communications hereunder shall be in
writing, shall be sent by U.S. Mail or a nationally recognized overnight express
courier postage prepaid, and shall be deemed given one day after being so sent,
or if delivered by hand shall be deemed given on the date of such delivery to
such party, or if sent to such party (in the case of a Holder) at its address in
the Warrant Register that will be maintained by the Company or its agent in
accordance with Section B hereof or (in the case of the Company) at its address
set forth above, Attention: Chief Financial Officer, or to such other address as
is designated by written notice, similarly given to each other party hereto.

         Section P. Governing Law. This Warrant shall be deemed to be a contract
made under the laws of the Commonwealth of Pennsylvania and for all purposes
shall be construed in accordance with the laws of said Commonwealth as applied
to contracts made and to be performed in Pennsylvania between Pennsylvania
residents.

<PAGE>

         IN WITNESS WHEREOF, the Company has duly caused this Warrant to be
signed and attested by its duly authorized officer and to be dated as of May 23,
2003.

                                    GENAERA CORPORATION

                                    By:_________________________________________
                                    Name:  Roy C. Levitt, M.D.
                                    Title: President and Chief Executive Officer

<PAGE>

                               NOTICE OF EXERCISE

                                                      Date: ______________, 20__

         The undersigned hereby elects to exercise this Warrant to purchase ____
shares of Common Stock and hereby makes payment of $____________ in payment of
the exercise price thereof.

                                                ________________________________
                                                [Holder's Name]

                                                By:_____________________________
                                                Name:
                                                Title:

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