Document:

Memo of Understanding

 Exhibit 10.1 
 MEMO OF UNDERSTANDING 
 The purpose of this memorandum is to outline the basis of the work and compensation that will
be performed by Lawrence A. Collett (Chairman) after he retires as Chief Executive Officer and assumes the role of Chairman of the Board of, and consultant to, Cass Information Systems, Inc. 
  

	 	I.	Role and Responsibilities 

 The Chairman’s duties
shall be as set forth in the description attached to this memorandum. 
  

	 	II.	Time Commitments 

 It is expected that the Chairman will
spend not more than one day per week engaged in the above duties or activities as requested by the Company. 
 This new position will begin
July 20, 2008. 
 It is understood that this position will be for an initial three-year period, but can be extended upon the mutual
agreement of the Chairman and the Board of Directors. It is recognized this understanding can be terminated at any time by either party. 
  

	 	III.	Compensation 

  

	 	A.	Annual Fee – For serving in the outlined capacity, the Chairman shall receive a fee of $150,000 per year, paid monthly. 

  

	 	B.	The Chairman shall also receive the annual stock compensation and the monthly Board of Directors retainer and monthly meeting fees. In addition he will receive fees for each loan
committee meeting he attends as a member of that committee. He shall not receive a fee as an ex-officio member of other board committees. 

  

	 	C.	He will be reimbursed for business-related expenses including but not limited to, country club membership and automobile expenses at a level equivalent to that provided during
employment, and membership dues for organizations such as the Regional Business Council and CEO Council which, in the Board’s opinion, are beneficial for the Company. 

  

	 	IV.	Other Compensation Issues 

  

	 	A.	He will not participate in the Profit Sharing Plan of the Company after 6/30/2008. 

  

	 	B.	He will retain full interest in the stock bonus awards and stock option awards that have been provided up to the time of his retirement. These will be allowed to vest according to
the original schedule and terms of the individual agreements with respect to all matters other than the terms of the individual agreements relating to the termination of Mr. Collett’s employment. 

	 	V.	Future Contingencies 

  

	 	A.	The annual fee, board fees and board stock compensation shall cease in the event of the Chairman’s death. 

  

	 	B.	In the event of disability, all payments would continue until the Board of Directors determined that the Chairman could not serve as originally planned for the duration of the term.

  

							
	 Cass Information Systems, Inc.
	 		 	
				
	By:	 	 /s/ Eric H. Brunngraber
	 		 	 /s/ Lawrence A. Collett

	Name:	 	Eric H. Brunngraber	 		 	Lawrence A. Collett
	Title:	 	President and Chief Operating OfficerFourth Amendment to Employment Agreement

 EXHIBIT 10.109 
 FOURTH AMENDMENT TO EMPLOYMENT AGREEMENT 
 This Fourth Amendment to Employment Agreement (the
“Amendment”) is entered into as of July 11, 2008, to be effective August 13, 2008 (the “Effective Date”), between Roger G. Stoll, Ph.D. (the “Executive”) and Cortex Pharmaceuticals, Inc. (the
“Company”). 
 RECITALS 
 On October 29, 2002, the Company and the Executive entered into an Employment Agreement, which the parties subsequently amended on April 8, 2003, November 10, 2004 and August 13, 2005 (as amended, the
“Agreement”). 
 The Executive served as the Company’s President and Chief Executive Officer pursuant to the terms of the
Agreement, and the parties wish to amend the Agreement pursuant to the terms and conditions set forth below. 
 AGREEMENT 

NOW THEREFORE, in consideration of the foregoing and the mutual agreements contained herein, the parties hereby agree as follows effective as of the
Effective Date. Except as otherwise defined herein, capitalized terms shall have the meanings assigned to them in the Agreement. 
 1. The
first sentence of Section 1 of the Agreement shall be amended in its entirety to read as follows: 
 “Engagement. During the
term of this Agreement, the Company hereby employs the Executive as its Executive Chairman, reporting to the Company’s Board of Directors, and the Executive hereby accepts such employment, on the terms and conditions hereinafter set
forth.” 
 2. Section 2 of the Agreement shall be amended in its entirety to read as follows: 
 “Term. The term of this Agreement shall expire on August 13, 2009.” 
 3. Section 3 of the Agreement shall be amended in its entirety to read as follows: 
 “Duties. During the term of this Agreement, the Executive shall serve as the Company’s Executive Chairman, and shall have such duties
and responsibilities as are set forth in the Company’s Bylaws and such other executive responsibilities as may be assigned to him from time to time by the Board of Directors. In particular and without limitation, the Executive’s duties
shall include using diligent efforts as appropriate to (i) assist in raising additional equity capital and research and development funds for the Company, (ii) act as the Chair of the Company’s Executive Committee meetings,
(iii) be responsible for stockholder relations and maintain relationships with analysts and fund managers, (iv) develop relationships with potential corporate partners for the licensing, development and commercialization of the
Company’s 

 
technologies, and (v) lead any merger and acquisition activities involving the Company. The Executive shall use his best efforts and shall act in
good faith in performing all duties reasonably required to be performed by him under this Agreement.” 
 4. The first two sentences of
Section 5(e) of the Agreement shall be amended in their entirety to read as follows: 
 “(e) To allow the Executive to have five
(5) days of paid time off each month during the term of this Agreement. The Company and the Executive agree that time devoted by the Executive toward travel to, and attendance at, scientific meetings, boards of director meetings, and trips
to meet with business leaders at trade associations shall not constitute paid time off.” 
 5. Section 8(b) of the Agreement shall
be amended in its entirety to read as follows: 
 “(b) The Executive may terminate his employment under this Agreement at any time for
“Good Reason” (as hereinafter defined) upon notice to the Company as described in Section 9(b). As used herein, the term “Good Reason” shall mean only (i) the Company’s breach of any of the material terms of this
Agreement, (ii) a material reduction in the Executive’s title or a material reduction or alteration of the duties of the Executive, or (iii) the relocation absent the Executive’s consent of the Company’s principal place of
business to a location outside of Orange County, California. The Company and Executive agree that the conversion of Executive’s position with the Company to Executive Chairman in connection with this Agreement shall not constitute grounds for a
Good Reason termination.” 
 6. The following shall be added as Sections 9(b) and 9(c) of the Agreement, and the existing
Section 9(b) of the Agreement shall be designated as Section 9(d): 
 “(b) In order to terminate his employment under this
Agreement for Good Reason, the Executive must provide written notice to the Company of the existence of the condition giving rise to Good Reason (a “Good Reason Condition”) within ninety (90) days of the initial existence of such Good
Reason Condition. Upon receipt of such notice of the Good Reason Condition, the Company will be provided with a period of thirty (30) days during which it may remedy the Good Reason Condition and not be required to provide for the payments and
benefits described herein as a result of such proposed resignation due to the Good Reason Condition specified in the notice. If the Good Reason Condition is not remedied within the period specified in the preceding sentence, the Executive may resign
for Good Reason based on the Good Reason Condition specified in the notice, provided that such resignation must occur within two years after the initial existence of such Good Reason Condition. 
 (c) In the event of either a termination by the Company of the Executive’s employment without Cause or the Executive’s termination of his
employment for Good Reason in either case which constitutes a “separation from service” within the meaning of Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”) and the regulations promulgated
thereunder, including Treasury Regulation Section 1.409A-1(h) (a “Separation from Service”), the Company shall pay to the Executive severance in an amount equal to twelve months of the Executive’s then current salary, which
severance shall be paid in accordance with its normal payroll practices over the twelve months following the Separation from Service. Termination of 

  

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employment under this Section 9 shall not terminate the Executive’s obligations under Sections 6 and 7. In addition, the parties agree that the
expiration of the term of this Agreement shall not constitute a termination by the Company of the Executive’s employment without Cause.” 
 7. The second sentence of Section 10 of the Agreement shall be amended in its entirety to read as follows: 
 “In such
event, provided that the termination constitutes a Separation from Service, the Company shall compensate the Executive in an amount equal to the excess, if any, of (a) twelve (12) months of the Executive’s then current salary for a
period of one year, over (b) any disability insurance proceeds, and such payments shall be paid by the Company in accordance with its normal payroll practices over the twelve months following the Separation from Service.” 
 8. The following shall be added Section 13 of the Agreement, with the subsequent sections renumbered accordingly: 
 “Code Section 409A. 
 (a) Notwithstanding any provision to the contrary in this Agreement, if the Executive is deemed by the Company at the time of his Separation from Service to be a “specified employee” for purposes of Section 409A(a)(2)(B)(i)
of the Code, to the extent delayed commencement of any portion of the benefits to which Executive is entitled under this Agreement is required in order to avoid a prohibited distribution under Section 409A(a)(2)(B)(i) of the Code, such portion
of Executive’s benefits shall not be provided to Executive prior to the earlier of (a) the expiration of the six-month period measured from the date of the Executive’s Separation from Service with the Company or (b) the date of
Executive’s death. Upon the first business day following the expiration of the applicable Code Section 409A(a)(2)(B)(i) period, all payments deferred pursuant to this Section 13(a) shall be paid in a lump sum to Executive, and any
remaining payments due under the Agreement shall be paid as otherwise provided herein. For purposes of Section 409A of the Code (including, without limitation, for purposes of Treasury Regulation Section 1.409A-2(b)(2)(iii)),
Executive’s right to receive the installment payments payable pursuant to Section 9 or 10 (the “Installment Payments”) shall be treated as a right to receive a series of separate payments and, accordingly, each Installment
Payment shall at all times be considered a separate and distinct payment. 
 (b) Any reimbursements payable to the Executive
pursuant to this Agreement shall be paid to the Executive no later than December 31 of the year following the year in which the cost was incurred. The amount of expenses reimbursed in one year shall not affect the amount eligible for
reimbursement in any subsequent year, and the Executive’s right to reimbursement under this Agreement will not be subject to liquidation or exchange for another benefit.” 
 9. Except as set forth herein, all other terms and conditions of the Agreement shall remain in full force and effect. 
  

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 IN WITNESS WHEREOF, the parties have executed this Amendment as of the Effective Date. 
  

			
	EXECUTIVE
	
	/s/ Roger G. Stoll
	Roger G. Stoll, Ph.D.
	
	CORTEX PHARMACEUTICALS, INC.
		
	By:	 	/s/ M. Ross Johnson
		 	M. Ross Johnson, Ph.D.
	Its:	 	Chairman, Compensation Committee

  

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