Document:

Second Supplemental Indenture, dated as of May 29, 2012

 Exhibit 4.3 
 SECOND SUPPLEMENTAL INDENTURE 
 The Supplemental Indenture (this
“Second Supplemental Indenture”), dated as of May 29, 2012, among Medco Health Solutions, Inc., a corporation duly organized and existing under the laws of the State of Delaware (the “Company”), the Guarantors
listed as signatories hereto (each, an “Existing Guarantor” and collectively, the “Existing Guarantors”) and certain subsidiaries of the Company, listed as signatories hereto (each, an “Additional
Guarantor,” and, collectively, the “Additional Guarantors” and, together with the Existing Guarantors, the Guarantors”) and U.S. Bank Trust National Association, as trustee under the indenture referred to below
(the “Trustee”). 
 W I T N E S S E T H 

WHEREAS, the Company, the Existing Guarantors and the Trustee are parties to the indenture, dated as of March 18, 2008 (the
“Base Indenture”), relating to the Company’s 6.125% Notes due 2013, its 7.125% Notes due 2018, its 2.750% Notes due 2015 and its 4.125% Notes due 2020 (collectively, the “Notes”), as supplemented by the First
Supplemental Indenture to the Base Indenture, dated as of April 2, 2012, to add guarantees; 
 WHEREAS, each Additional
Guarantor desires to provide a full and unconditional guarantee (the “Guarantee”) of the obligations of the Company under the Notes, the Securities (as defined in the Base Indenture) and the Base Indenture on the terms and
conditions set forth herein; 
 WHEREAS, the Company has complied with all conditions precedent provided for in the Base
Indenture relating to this Second Supplemental Indenture; and 
 WHEREAS, pursuant to Section 901 of the Base Indenture,
the Company is permitted to amend the Base Indenture to make any provision with respect to matters or questions arising under the Base Indenture, provided such action does not adversely affect the interest of the Holders. 

NOW, THEREFORE, for good and valuable consideration, the receipt of which is acknowledged, each Additional Guarantor hereby guarantees
the Company’s obligations under the Securities as follows: 
 1. Capitalized Terms. Capitalized terms used herein
without definition shall have the meanings assigned to them in the Base Indenture. 
 2. Unconditional Guarantee.
(1) For value received, each of the Additional Guarantors hereby jointly and severally and fully and unconditionally guarantee, to each Holder of a Security authenticated and delivered by the Trustee (including the Notes) and to the Trustee and
its successors and assigns, irrespective of the validity and enforceability of the Indenture or the Securities or the obligations of the Company or any other Guarantor to the Holders or the Trustee hereunder or thereunder, that: (a) the
principal of, premium, if any, and interest on the Securities will be duly and promptly paid in full when due, whether at Stated Maturity, upon redemption, by acceleration or otherwise, and interest on the overdue principal and (to the extent
permitted by law) interest, if any, on the Securities and all other obligations of the Company or the Guarantor to the Holders of or the Trustee hereunder or thereunder (including fees, expenses or others) (collectively, the
“Obligations”) will be promptly paid in full or performed, all in accordance with the terms hereof and thereof; and (b) in case of any extension of time of payment or renewal of any Obligations (with or without notice to such
Guarantor), the same will be promptly paid in full when due or performed in accordance with the terms of the extension or renewal, whether at Stated Maturity, by acceleration or otherwise. If the Company shall fail to pay when due, or to perform,
any Obligations, for whatever reason, each Guarantor shall be jointly and severally obligated to pay in cash, or to perform or cause the performance of, the same promptly. An Event of Default under the Indenture or the Securities of a particular
series shall entitle the Holders of the Securities of such series to accelerate the Obligations of the Guarantor hereunder in the same manner and to the same extent as the Obligations of the Company. 

(2) Each Additional Guarantor hereby agrees that its obligations hereunder shall be unconditional, irrespective of the validity,
regularity or enforceability of the Securities or the Indenture, the absence of any action to enforce the same, any waiver or consent by any Holder of the Securities with respect to any provisions of the Indenture or the Securities, any release of
any other Guarantor, the recovery of any judgment against the Company, any action to enforce the same, whether or not a Guarantee is affixed to any particular Security, or any other circumstance which might otherwise constitute a legal or equitable
discharge or defense of a Guarantor. 

 (3) Each Additional Guarantor further agrees that, as between it, on the one hand, and the
Holders of the Securities and the Trustee, on the other hand, (a) the maturity of the Obligations guaranteed hereby may be accelerated as provided in Article Five of the Base Indenture for the purposes of the Guarantee, notwithstanding any
stay, injunction or other prohibition preventing such acceleration in respect of the Obligations and (b) in the event of any acceleration of such Obligations as provided in Article Five of the Base Indenture, such Obligations (whether or not
due and payable) shall forthwith become due and payable by the Guarantor for the purposes of its Guarantee. 
 3. Waiver.
To the fullest extent permitted by applicable law, each of the Additional Guarantors waives diligence, presentment, demand of, payment, filing of claims with a court in the event of insolvency or bankruptcy of the Company, any right to require a
proceeding first against the Company, protest, notice and all demands whatsoever and covenants that the Guarantee will not be discharged except by complete performance of the Obligations contained in the Securities and the Indenture. 

4. Guarantee of Payment. Each of the Additional Guarantors further agrees that its Guarantee constitutes a guarantee of payment,
performance and compliance when due and not a guarantee of collection, and waives any right to require that any resort be had by the Trustee or any Holder of the Securities to the security, if any, held for payment of the Obligations. 

5. No Discharge or Diminishment of Guarantee. Subject to Section 11 hereof, the obligations of each of the Additional
Guarantors hereunder shall not be subject to any reduction, limitation, termination, impairment or for any reason (other than the payment in full in cash of the Obligations), including any claim of waiver, release, surrender, alteration or
compromise of any of the Obligations, and shall not be subject to any defense or setoff, counterclaim, recoupment or termination whatsoever by reason of the invalidity, illegality or unenforceability of the Obligations or otherwise. Without limiting
the generality of the foregoing, the obligations of each of the Additional Guarantors hereunder shall not be discharged or impaired or otherwise affected by the failure of the Trustee or any Holder of the Securities to assert any claim or demand or
to enforce any remedy under the Indenture or the Securities, any other guarantee or any other agreement, by any waiver or modification of any provision thereof, by any default, failure or delay, willful or otherwise, in the performance of the
Obligations, or by any other act or omission or delay to do any other act that may or might in any manner or to any extent vary the risk of any Guarantor or that would otherwise operate as a discharge of any Guarantor as a matter of law or equity
(other than the payment in full in cash of all the Obligations). 
 6. Defenses of Company Waived. To the extent
permitted by applicable law, each of the Additional Guarantors waives any defense based on or arising out of any defense of the Company or any other Guarantor or the unenforceability of the Obligations or any part thereof from any cause, or the
cessation from any cause of the liability of the Company, other than final payment in full in cash of the Obligations. Each of the Additional Guarantors waives any defense arising out of any such election even though such election operates to impair
or to extinguish any right of reimbursement or subrogation or other right or remedy of each of the Guarantors against the Company or any security. 
 7. Continued Effectiveness. Subject to Section 11 hereof, each of the Additional Guarantors further agrees that its Guarantee hereunder shall continue to be effective or be reinstated, as the
case may be, if at any time payment, or any part thereof, of principal of or interest on any Obligation is rescinded or must otherwise be restored by the Trustee or any Holder of the Securities upon the bankruptcy or reorganization of the Company or
otherwise. 
 8. Subrogation. In furtherance of the foregoing and not in limitation of any other right of each of the
Additional Guarantors by virtue hereof, upon the failure of the Company to pay any Obligation when and as the same shall become due, whether at maturity, by acceleration, after notice of prepayment or otherwise, each of the Additional Guarantors
hereby promises to and will, upon receipt of written demand by the Trustee or any Holder of the Securities, forthwith pay, or cause to be paid, to the Holders in cash the amount of such unpaid Obligations, and thereupon the Holders shall assign
(except to the extent that such assignment would render a 

 
Guarantor a “creditor” of the Company within the meaning of Section 547 of Title 11 of the United States Code as now in effect or hereafter amended or any comparable provision of
any successor statute) the amount of the Obligations owed to it and paid by such Additional Guarantor pursuant to this Guarantee to such Additional Guarantor, such assignment to be pro rata to the extent the Obligations in question were discharged
by such Additional Guarantor, or make such other disposition thereof as such Additional Guarantor shall direct (all without recourse to the Holders, and without any representation or warranty by the Holders). If (a) an Additional Guarantor
shall make payment to the Holders of all or any part of the Obligations and (b) all the Obligations and all other amounts payable under the Indenture shall be paid in full, the Trustee will, at such Additional Guarantor’s request, execute
and deliver to such Additional Guarantor appropriate documents, without recourse and without representation or warranty, necessary to evidence the transfer by subrogation to such Additional Guarantor of an interest in the Obligations resulting from
such payment by such Additional Guarantor. 
 9. Information. Each of the Additional Guarantors assumes all
responsibility for being and keeping itself informed of the Company’s financial condition and assets, and of all other circumstances bearing upon the risk of nonpayment of the Obligations and the nature, scope and extent of the risks that each
of the Additional Guarantors assumes and incurs hereunder, and agrees that the Trustee and the Holders of the Securities will have no duty to advise the Additional Guarantors of information known to it or any of them regarding such circumstances or
risks. 
 10. Subordination. Upon payment by any Additional Guarantor of any sums to the Holders, as provided above, all
rights of such Additional Guarantor against the Company, arising as a result thereof by way of right of subrogation or otherwise, shall in all respects be subordinated and junior in right of payment to the prior payment in full in cash of all the
Obligations to the Trustee; provided, however, that any right of subrogation that such Additional Guarantor may have pursuant to the Indenture is subject to Section 8 hereof. 

11. Release of Additional Guarantor. (1) An Additional Guarantor shall, upon notice by the Company to the Trustee, be
automatically and unconditionally released and discharged from all obligations under the Indenture and its Guarantee without any action required on the part of the Trustee or any Holder. 

(2) The Trustee shall deliver an appropriate instrument evidencing such release upon receipt of a request of the Company. Any Additional
Guarantor not so released will remain liable for the full amount of the principal of, premium, if any, and interest on the Securities provided in the Indenture and its Guarantee. 

12. Limitation of Additional Guarantor’s Liability. (1) Each Additional Guarantor, and by its acceptance hereof each
Holder, hereby confirms that it is the intention of all such parties that the Guarantee by such Additional Guarantor not constitute a fraudulent transfer or conveyance for purposes of Title 11 of the United States Code, the Uniform Fraudulent
Conveyance Act, the Uniform Fraudulent Transfer Act or any similar federal or state law to the extent applicable to any Additional Guarantor. To effectuate the foregoing intention, the Holders and such Additional Guarantor hereby irrevocably agree
that the obligations of such Additional Guarantor under the Indenture and its Guarantee shall be limited to the maximum aggregate amount which, after giving effect to all other contingent and fixed liabilities of such Additional Guarantor, and after
giving effect to any collections from or payments made by or on behalf of any other Guarantor in respect of the obligations of such Guarantor under its Guarantee or pursuant to its contribution obligations under the Indenture, will result in the
obligations of such Additional Guarantor under its Guarantee not constituting such fraudulent transfer or conveyance. 
 (2) The
Guarantee is expressly limited so that in no event, including the acceleration of the maturity of the Securities, shall the amount paid or agreed to be paid in respect of interest on the Securities (or fees or other amounts deemed payment for the
use of funds) exceed the maximum permissible amount under applicable law, as in effect on the date hereof and as subsequently amended or modified to allow a greater amount of interest (or fees or other amounts deemed payment for the use of funds) to
be paid under the Guarantee. If for any reason the amount in respect of interest (or fees or other amounts deemed payment for the use of funds) required by the Guarantee exceeds such maximum permissible amount, the obligation to pay interest under
the Guarantee (or fees or other amounts deemed payment for the use of funds) shall be automatically reduced to such maximum permissible amount and any amounts collected by any holder of any Security in excess of the permissible amount shall be
automatically applied to reduce the outstanding principal on such Security. 

 13. Contribution from Other Additional Guarantors. Each Additional Guarantor that
makes a payment or distribution under its Guarantee shall be entitled to seek contribution from each other non-paying Guarantor in a pro rata amount based on the net assets of each Guarantor, determined in accordance with generally accepted
accounting principles in effect in the United States of America as of the date hereof so long as the exercise of such right does not impair the rights of the Holders under the Guarantee. 

14. No Obligation to Take Action Against the Company. Neither the Trustee, any Holder nor any other Person shall have any
obligation to enforce or exhaust any rights or remedies or take any other steps under any security for the Obligations or against the Company or any other Person or any Property of the Company or any other Person before the Trustee, such Holder or
such other Person is entitled to demand payment and performance by any or all Guarantors of their liabilities and obligations under their Guarantee. 
 15. Execution and Delivery of the Guarantee. (1) To further evidence the Guarantee set forth in this Second Supplemental Indenture, each Additional Guarantor hereby agrees that a notation of
such Guarantee shall be endorsed on each Security authenticated and delivered by the Trustee and executed by either manual or facsimile signature of an officer, manager or member, as applicable, of each Additional Guarantor. 

(2) Each of the Additional Guarantors hereby agrees that its Guarantee set forth in this Second Supplemental Indenture shall remain in
full force and effect notwithstanding any failure to endorse on each Security a notation of such Guarantee. 
 (3) If an
officer of an Additional Guarantor whose signature is on the Indenture or a Guarantee no longer holds that office or is no longer a manager or member, as applicable, at the time the Trustee authenticates such Guarantee or at any time thereafter,
such Additional Guarantor’s Guarantee of such Security shall be valid nevertheless. 
 (4) The delivery of any Security by
the Trustee, after the authentication thereof under the Indenture, shall constitute due delivery of any Guarantee set forth in the Indenture on behalf of each Additional Guarantor. 

16. Successor Additional Guarantor. Unless otherwise released and discharged from its obligations in accordance with the
Indenture, upon any consolidation or merger by any Additional Guarantor with or into any other Person, the successor Person formed by such consolidation or merger shall sign a supplemental indenture and guarantee and succeed to, and be substituted
for, and may exercise every right and power of, the Additional Guarantor under the Indenture with the same effect as if such successor Person has been named as a Guarantor herein, and thereafter the predecessor Person shall be relieved of all
obligations and covenants under the Indenture and the Securities (to the extent the Additional Guarantor was the predecessor Person). 
 17. Ratification of Base Indenture; Supplemental Indenture Part of Indenture. The Base Indenture is in all respects ratified and confirmed, and all terms, conditions and provisions thereof shall
remain in full force and effect. This Second Supplemental Indenture shall form a part of the Base Indenture for all purposes, and every Holder of Securities heretofore or hereafter authenticated and delivered shall be bound hereby. 

18. Representations and Warranties. Each Additional Guarantor hereby represents that (a) it is duly organized, validly
existing and in good standing under the laws of the jurisdiction of its organization, (b) it has full power, authority and legal rights to execute and deliver this Second Supplemental Indenture and to perform its obligations hereunder and under
the Base Indenture, (c) the execution, delivery and performance by it of this Second Supplemental Indenture has been duly authorized by all necessary corporate action, and no other proceedings or actions on the part of such Additional Guarantor
are necessary therefor and (d) this Second Supplemental Indenture has been duly and validly executed and delivered by such Additional Guarantor and constitutes a legal, valid and binding obligation of such Additional Guarantor, enforceable
against such Additional Guarantor in accordance with its terms (subject to applicable bankruptcy, insolvency, receivership, reorganization, moratorium and other similar laws of general applicability relating to or affecting creditors’ rights
and to general equity principles). 

 19. No Personal Liability of Directors, Officers, Employees or Stockholders. No
director, officer, employee, member or stockholder of any Additional Guarantor, as such, will have any liability for any obligations of the Company or any other Guarantor under the Securities, the Base Indenture or the Guarantees, or for any claim
based on, in respect of, or by reason of, such obligations or their creation. Each Holder of Securities, by accepting a Security, waives and releases the Company and each Additional Guarantor from all such liability. The waiver and release are part
of the consideration for issuance of the Guarantee by the Additional Guarantors. 
 20. GOVERNING LAW. THIS SECOND
SUPPLEMENTAL INDENTURE AND THE GUARANTEES HEREUNDER SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK. 
 21. Counterparts. This Second Supplemental Indenture may be executed in any number of counterparts, each of which shall be deemed an original; but all such counterparts shall together constitute
but one and the same instrument. 
 22. Effect of Headings. The Section headings herein are for convenience only and
shall not affect the construction hereof. 
 23. Trustee. The Trustee shall not be responsible in any manner whatsoever
for or in respect of the validity or sufficiency of this Second Supplemental Indenture or for or in respect of the recitals contained herein, all of which recitals are made solely by the Additional Guarantors and the Company. 

 IN WITNESS WHEREOF, the parties hereto have caused this Second Supplemental Indenture to be duly executed,
all as of the day and year first above written. 
  

			
	MEDCO HEALTH SOLUTIONS, INC.
		
	By:	 	 /s/ Keith J. Ebling

		 	Name: Keith J. Ebling
		 	Title: Vice President

 EXISTING GUARANTORS 

 

			
	EXPRESS SCRIPTS HOLDING COMPANY
		
	By:	 	 /s/ Keith J. Ebling

		 	Name: Keith J. Ebling
		 	 Title: Executive Vice President, General
           Counsel, and Secretary

  

			
	EXPRESS SCRIPTS, INC.
		
	By:	 	 /s/ Keith J. Ebling

		 	Name: Keith J. Ebling
		 	Title: Vice President

  

			
	AIRPORT HOLDINGS, LLC
	ESI REALTY, LLC
		
	By:	 	Express Scripts, Inc., as sole Member
		
	By:	 	 /s/ Keith J. Ebling

		 	Name: Keith J. Ebling
		 	Title:Vice President

 [Signature Page to 2008 Medco Second Supplemental Indenture] 

 BYFIELD DRUG, INC. 

CARE CONTINUUM, INC. 
 CFI OF NEW JERSEY, INC. 
 CHESAPEAKE INFUSION, INC.

 CONNECTYOURCARE COMPANY, LLC 

CONNECTYOURCARE, LLC 
 CURASCRIPT PBM SERVICES, INC. 
 DIVERSIFIED
PHARMACEUTICAL SERVICES, INC. 
 ESI ACQUISITION, INC. 

ESI CLAIMS, INC. 
 ESI ENTERPRISES, LLC 
 ESI MAIL ORDER PROCESSING, INC.

 EXPRESS SCRIPTS CANADA HOLDING, CO. 

EXPRESS SCRIPTS CANADA HOLDING, LLC 

EXPRESS SCRIPTS PHARMACEUTICAL PROCUREMENT, LLC 

EXPRESS SCRIPTS SERVICES COMPANY 

FRECO, INC. 
 FREEDOM SERVICE COMPANY, LLC 
 HEALTHBRIDGE, INC.

 HEALTHBRIDGE REIMBURSEMENT AND PRODUCT SUPPORT, INC. 

iBIOLOGIC, INC. 
 IVTX, INC. 
 LYNNFIELD COMPUNDING CENTER, INC.

 LYNNFIELD DRUG, INC. 

MATRIX GPO LLC 
 NATIONAL PRESCRIPTION ADMINISTRATORS, INC. 
 PRIORITY
HEALTHCARE CORPORATION 
 PRIORITY HEALTHCARE CORPORATION WEST 

PRIORITY HEALTHCARE DISTRIBUTION, INC. 

PRIORITY HEALTHCARE PHARMACY, INC. 

PRIORITYHEALTHCARE.COM, INC. 

SINUSPHARMACY, INC. 
 SPECIALTY INFUSION PHARMACY, INC. 
 SPECTRACARE, INC.

 SPECTRACARE HEALTH CARE VENTURES, INC. 

SPECTRACARE INFUSION PHARMACY, INC. 

VALUE HEALTH, INC. 
 YOURPHARMACY.COM, INC. 
 ACCREDO HEALTH, INCORPORATED

 ACCREDO HEALTH GROUP, INC. 

MEDCO HEALTH SERVICES, INC. 

 

			
		
	By:	 	 /s/ Keith J. Ebling

		 	Name: Keith J. Ebling
		 	Title: Vice President

 CURASCRIPT, INC. 

EXPRESS SCRIPTS UTILIZATION MANAGEMENT CO. 

EXPRESS SCRIPTS MSA, LLC 

EXPRESS SCRIPTS SENIOR CARE, INC. 

EXPRESS SCRIPTS SENIOR CARE HOLDINGS, INC. 

EXPRESS SCRIPTS WC, INC. 

 

			
		
	By:	 	 /s/ Martin P. Akins

		 	Name: Martin P. Akins
		 	Title: Assistant Secretary

 [Signature Page to 2008 Medco Second Supplemental Indenture] 

 
			
	 ESI MAIL PHARMACY SERVICE, INC.
 EXPRESS SCRIPTS SPECIALTY DISTRIBUTION SERVICES, INC.
 MOORESVILLE ON-SITE PHARMACY,
LLC

  

			
	By:	 	 /s/ Martin P. Akins

		 	Name: Martin P. Akins
		 	Title: Secretary

  

			
	ESI-GP HOLDINGS, INC.
	ESI RESOURCES, INC.
		
	By:	 	 /s/ Matt Dietrich

		 	Name: Matt Dietrich
		 	Title: Vice President

  

			
	ESI PARTNERSHIP
		
	By:	 	Express Scripts, Inc., as Partner
		
	By:	 	 /s/ Keith J. Ebling

		 	Name: Keith J. Ebling
		 	Title: Vice President

  

			
		
	By:	 	ESI-GP Holdings, Inc., as Partner
		
	By:	 	 /s/ Matt Dietrich

		 	Name: Matt Dietrich
		 	Title: Vice President

  

			
	SPECTRACARE OF INDIANA
		
	By:	 	Spectracare, Inc., as Partner
		
	By:	 	 /s/ Keith J. Ebling

		 	Name: Keith J. Ebling
		 	Title: Vice President

  

			
		
	By:	 	Care Continuum, Inc., as Partner
		
	By:	 	 /s/ Keith J. Ebling

		 	Name: Keith J. Ebling
		 	Title: Vice President

 [Signature Page to 2008 Medco Second Supplemental Indenture] 

 ADDITIONAL GUARANTORS 

ACCREDO CARE NETWORK, INC. 

AHG OF NEW YORK, INC. 
 BIOPARTNERS IN CARE, INC. 
 BRACKET GLOBAL, LLC

 CCS INFUSION MANAGEMENT, LLC 

CCSI HOLDING 3, LLC 
 CRITICAL CARE SYSTEMS OF NEW YORK, INC. 
 CRITICAL CARE
SYSTEMS, INC. 
 DNA DIRECT, INC. 

ENVISION PHARMA INC. 
 EVIDENCE SCIENTIFIC SOLUTIONS, INC. 
 HIDDEN RIVER,
L.L.C. 
 HOME HEALTHCARE RESOURCES, INC. 

INFINITY INFUSION II, LLC 

INFINITY INFUSION, LLC 
 INSTITUTE FOR MEDICAL EDUCATION & RESEARCH, INC. 

LIBERTY HEALTHCARE GROUP, INC. 

LIBERTY HEALTHCARE PHARMACY OF NEVADA, LLC 

LIBERTY LANE DEVELOPMENT COMPANY, INC. 

LIBERTY MARKETPLACE, INC. 

LIBERTY MEDICAL SUPPLY, INC. 

MAH PHARMACY, L.L.C. 
 MAH PROCESSING, INC. 
 MEDCO AT HOME, L.L.C.

 MEDCO CDUR, L.L.C. 

MEDCO CHP, L.L.C. 
 MEDCO CONTINUATION HEALTH, L.L.C. 
 MEDCO EUROPE,
L.L.C. 
 MEDCO EUROPE II, L.L.C. 

MEDCO HEALTH, L.L.C. 
 MEDCO HEALTH NEW YORK INDEPENDENT PRACTICE ASSOCIATION, L.L.C. 
 MEDCO HEALTH PUERTO RICO, L.L.C. 
 MEDCO HEALTH
SOLUTIONS OF COLUMBUS NORTH, LTD. 
 MEDCO HEALTH SOLUTIONS OF COLUMBUS WEST, LTD. 

MEDCO HEALTH SOLUTIONS OF FAIRFIELD, L.L.C. 

MEDCO HEALTH SOLUTIONS OF FRANKLIN LAKES, L.L.C. 

MEDCO HEALTH SOLUTIONS OF HENDERSON, NEVADA, L.L.C. 

MEDCO HEALTH SOLUTIONS OF HIDDEN RIVER, L.C. 

MEDCO HEALTH SOLUTIONS OF ILLINOIS, L.L.C. 

MEDCO HEALTH SOLUTIONS OF INDIANA, L.L.C. 

MEDCO HEALTH SOLUTIONS OF IRVING, L.L.C. 

MEDCO HEALTH SOLUTIONS OF LAS VEGAS, L.L.C. 

MEDCO HEALTH SOLUTIONS OF NETPARK, L.L.C. 

MEDCO HEALTH SOLUTIONS OF NORTH VERSAILLES, L.L.C. 

MEDCO HEALTH SOLUTIONS OF RICHMOND, L.L.C. 

MEDCO HEALTH SOLUTIONS OF SPOKANE, L.L.C. 

MEDCO HEALTH SOLUTIONS OF TEXAS, L.L.C. 

MEDCO HEALTH SOLUTIONS OF WILLINGBORO, L.L.C. 

MEDCO HEALTH.COM, L.L.C. 

MEDCO OF WILLINGBORO URBAN RENEWAL, L.L.C. 

MEDCO RESEARCH INSTITUTE, L.L.C. 

NATIONAL DIABETIC MEDICAL SUPPLY, L.L.C. 

NATIONAL RX SERVICES NO. 3, INC. OF OHIO 

[Signature Page to 2008 Medco Second Supplemental Indenture] 

			
	 P-STAR ACQUISITION CO., INC.
 POLYMEDICA CORPORATION
 SYSTEMED, L.L.C.

THE VACCINE CONSORTIUM, LLC
 THERAPEASE
CUISINE, INC.
 TVC ACQUISITION CO., INC.
 UBC HEALTH CARE ANALYTICS, INC.
 UBC LATE STAGE, INC.

UBC SCIENTIFIC SOLUTIONS, INC.
 UNITED
BIOSOURCE CORPORATION
 UNITED BIOSOURCE PATIENT SOLUTIONS,     INC.

  

			
	By:	 	 /s/ Keith J. Ebling

		 	Name: Keith J. Ebling
		 	Title: Vice President

  

			
	INFINITY INFUSION CARE, LTD.
	
	By: Infinity Infusion, LLC, as Partner
		
	By:	 	 /s/ Keith J. Ebling

	Name:	 	Keith J. Ebling
	Title:	 	Vice President
	
	By: Infinity Infusion II, LLC, as Partner
		
	By:	 	 /s/ Keith J. Ebling

	Name:	 	Keith J. Ebling
	Title:	 	Vice President

 [Signature Page to 2008 Medco Second Supplemental Indenture] 

 
			
	U.S. BANK TRUST NATIONAL ASSOCIATION, AS TRUSTEE
		
	By	 	 /s/ Patrick J. Crowley

		 	Name: Patrick J. Crowley
		 	Title: Vice President

 [Signature Page to 2008 Medco Second Supplemental Indenture]Subsidiary Guaranty, dated as of April 2, 2012

 Exhibit 4.4 
 SUBSIDIARY GUARANTY 
 This SUBSIDIARY GUARANTY is entered into as of
April 2, 2012, by and among THE UNDERSIGNED (each a “Guarantor”, and, together with any Additional Guarantors (as hereinafter defined), collectively the “Guarantors”) in favor of and for the benefit of
Credit Suisse AG, Cayman Islands Branch, as agent for and representative of (in such capacity herein called “Guarantied Party”) the financial institutions party to the Credit Agreement (as hereinafter defined) (the
“Lenders”) referred to below, and, subject to subsection 3.12, for the benefit of the other Beneficiaries (as hereinafter defined). 
 RECITALS 
 A. Aristotle Holding, Inc. (to be renamed Express Scripts
Holding Company), a Delaware corporation, has entered into that certain Credit Agreement dated as of August 29, 2011, with Express Scripts, Inc., a Delaware corporation, the financial institutions from time to time party thereto as Lenders and
Credit Suisse AG, Cayman Islands Branch, as Administrative Agent (as amended, supplemented or otherwise modified from time to time, the “Credit Agreement”; capitalized terms defined therein and not otherwise defined herein being
used herein as therein defined). 
 B. Each Guarantor is an Affiliate of Company and will derive substantial benefits from the
extension of credit to Company pursuant to the Credit Agreement. 
 C. It is a condition precedent to the making of the Loans
under the Credit Agreement that Company’s obligations thereunder be guarantied by Guarantors. 
 D. Guarantors are willing
irrevocably and unconditionally to guaranty such obligations of Company. 
 NOW, THEREFORE, based upon the
foregoing and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, and in order to induce Lenders and Guarantied Party to enter into the Credit Agreement and to make Loans and other extensions of
credit thereunder, Guarantors hereby agree as follows: 
 SECTION 1. DEFINITIONS 

1.1 Certain Defined Terms. As used in this Guaranty, the following terms shall have the following meanings unless the
context otherwise requires: 
 “Beneficiaries” means Guarantied Party and Lenders. 

“Guarantied Obligations” has the meaning assigned to that term in subsection 2.1. 

 “Guaranty” means this Subsidiary Guaranty, as it may be amended,
supplemented or otherwise modified from time to time. 
 “payment in full”, “paid in full” or
any similar term means payment in full of the Guarantied Obligations, including all principal, interest, costs, fees and expenses (including reasonable legal fees and expenses) of Beneficiaries as required under the Loan Documents. 

1.2 Interpretation. 
 (a) References to “Sections” and “subsections” shall be to Sections and subsections, respectively, of this Guaranty unless otherwise specifically provided. 

(b) In the event of any conflict or inconsistency between the terms, conditions and provisions of this Guaranty and the terms, conditions
and provisions of the Credit Agreement, the terms, conditions and provisions of this Guaranty shall prevail. 
 SECTION 2. THE GUARANTY

 2.1 Guaranty of the Guarantied Obligations. Subject to the provisions of subsection 2.2(a), Guarantors
jointly and severally hereby irrevocably and unconditionally guaranty, as primary obligors and not merely as sureties, the due and punctual payment in full of all Guarantied Obligations when the same shall become due, whether at stated maturity, by
required prepayment, declaration, acceleration, demand or otherwise (including amounts that would become due but for the operation of the automatic stay under Section 362(a) of the Bankruptcy Code, 11 U.S.C. § 362(a)). The term
“Guarantied Obligations” is used herein in its most comprehensive sense and includes: 
 (a) any
and all Obligations of Company, in each case now or hereafter made, incurred or created, whether absolute or contingent, liquidated or unliquidated, whether due or not due, and however arising under or in connection with the Credit Agreement and the
other Loan Documents, including those arising under successive borrowing transactions under the Credit Agreement which shall either continue the Obligations of Company or from time to time renew them after they have been satisfied and including
interest which, but for the filing of a petition in bankruptcy with respect to Company, would have accrued on any Guarantied Obligations, whether or not a claim is allowed against Company for such interest in the related bankruptcy proceeding; and

 (b) those expenses set forth in subsection 2.8. 

2.2 Limitation on Amount Guarantied; Contribution by Guarantors. (a) Anything contained in this Guaranty to the
contrary notwithstanding, if any Fraudulent Transfer Law (as hereinafter defined) is determined by a court of competent jurisdiction to be applicable to the obligations of any Guarantor under this Guaranty, such obligations of such Guarantor
hereunder shall be limited to a maximum aggregate amount equal to the largest amount that would not render its obligations hereunder subject to 

  
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avoidance as a fraudulent transfer or conveyance under Section 548 of Title 11 of the United States Code or any applicable provisions of comparable state law (collectively, the
“Fraudulent Transfer Laws”), in each case after giving effect to all other liabilities of such Guarantor, contingent or otherwise, that are relevant under the Fraudulent Transfer Laws (specifically excluding, however, any
liabilities of such Guarantor (x) in respect of intercompany indebtedness to Company or other affiliates of Company to the extent that such indebtedness would be discharged in an amount equal to the amount paid by such Guarantor hereunder and
(y) under any guaranty of Indebtedness of Company or its Subsidiaries subordinated or junior in right of payment to the Guarantied Obligations which guaranty contains a limitation as to maximum amount similar to that set forth in this
subsection 2.2(a), pursuant to which the liability of such Guarantor hereunder is included in the liabilities taken into account in determining such maximum amount) and after giving effect as assets to the value (as determined under the applicable
provisions of the Fraudulent Transfer Laws) of any rights to subrogation, reimbursement, indemnification or contribution of such Guarantor pursuant to applicable law or pursuant to the terms of any agreement (including any such right of contribution
under subsection 2.2(b). 
 (b) Guarantors under this Guaranty together desire to allocate among themselves in a fair and
equitable manner, their obligations arising under this Guaranty. Accordingly, in the event any payment or distribution is made on any date by any Guarantor under this Guaranty (a “Funding Guarantor”) that exceeds its Fair Share (as
defined below) as of such date, that Funding Guarantor shall be entitled to a contribution from each of the other Guarantors in the amount of such other Guarantor’s Fair Share Shortfall (as defined below) as of such date, with the result that
all such contributions will cause each Guarantor’s Aggregate Payments (as defined below) to equal its Fair Share as of such date. “Fair Share” means, with respect to a Guarantor as of any date of determination, an amount equal
to (i) the ratio of (x) the Adjusted Maximum Amount (as defined below) with respect to such Guarantor to (y) the aggregate of the Adjusted Maximum Amounts with respect to all Guarantors multiplied by (ii) the
aggregate amount paid or distributed on or before such date by all Funding Guarantors under this Guaranty in respect of the obligations guarantied. “Fair Share Shortfall” means, with respect to a Guarantor as of any date of
determination, the excess, if any, of the Fair Share of such Guarantor over the Aggregate Payments of such Guarantor. “Adjusted Maximum Amount” means, with respect to a Guarantor as of any date of determination, the maximum
aggregate amount of the obligations of such Guarantor under this Guaranty determined as of such date, in the case of any Guarantor, in accordance with subsection 2.2(a); provided that, solely for purposes of calculating the “Adjusted
Maximum Amount” with respect to any Guarantor for purposes of this subsection 2.2(b), any assets or liabilities of such Guarantor arising by virtue of any rights to subrogation, reimbursement or indemnification or any rights to or obligations
of contribution hereunder shall not be considered as assets or liabilities of such Guarantor. “Aggregate Payments” means, with respect to a Guarantor as of any date of determination, an amount equal to (i) the aggregate amount
of all payments and distributions made on or before such date by such Guarantor in respect of this Guaranty (including in respect of this subsection 2.2(b)) minus (ii) the aggregate amount of all payments received on or before such date
by such Guarantor from the other Guarantors as contributions under this 

  
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subsection 2.2(b). The amounts payable as contributions hereunder shall be determined as of the date on which the related payment or distribution is made by the applicable Funding Guarantor. The
allocation among Guarantors of their obligations as set forth in this subsection 2.2(b) shall not be construed in any way to limit the liability of any Guarantor hereunder. 
 2.3 Payment by Guarantors; Application of Payments. Subject to the provisions of subsection 2.2(a), Guarantors hereby jointly and severally agree, in furtherance of the foregoing and not in
limitation of any other right which any Beneficiary may have at law or in equity against any Guarantor by virtue hereof, that upon the failure of Company to pay any of the Guarantied Obligations when and as the same shall become due, whether at
stated maturity, by required prepayment, declaration, acceleration, demand or otherwise (including amounts that would become due but for the operation of the automatic stay under Section 362(a) of the Bankruptcy Code, 11 U.S.C.
§ 362(a)), Guarantors will upon demand pay, or cause to be paid, in cash, to Guarantied Party for the ratable benefit of Beneficiaries, an amount equal to the sum of the unpaid principal amount of all Guarantied Obligations then due as
aforesaid, accrued and unpaid interest on such Guarantied Obligations (including interest which, but for the filing of a petition in bankruptcy with respect to Company, would have accrued on such Guarantied Obligations, whether or not a claim is
allowed against Company for such interest in the related bankruptcy proceeding) and all other Guarantied Obligations then owed to Beneficiaries as aforesaid. All such payments shall be applied promptly from time to time by Guarantied Party as
provided in subsection 2.4C of the Credit Agreement. 
 2.4 Liability of Guarantors Absolute. Each Guarantor
agrees that its obligations hereunder are irrevocable, absolute, independent and unconditional and shall not be affected by any circumstance which constitutes a legal or equitable discharge of a guarantor or surety other than payment in full of the
Guarantied Obligations. In furtherance of the foregoing and without limiting the generality thereof, each Guarantor agrees as follows: 
 (a) This Guaranty is a guaranty of payment when due and not of collectibility. 
 (b) Guarantied Party may enforce this Guaranty upon the occurrence of an Event of Default under the Credit Agreement notwithstanding the existence of any dispute between Company and any Beneficiary with
respect to the existence of such Event of Default. 
 (c) The obligations of each Guarantor hereunder are
independent of the obligations of Company under the Loan Documents and the obligations of any other guarantor (including any other Guarantor) of the obligations of Company under the Loan Documents, and a separate action or actions may be brought and
prosecuted against such Guarantor whether or not any action is brought against Company or any of such other guarantors and whether or not Company is joined in any such action or actions. 

  
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 (d) Payment by any Guarantor of a portion, but not all, of the Guarantied
Obligations shall in no way limit, affect, modify or abridge any Guarantor’s liability for any portion of the Guarantied Obligations which has not been paid. Without limiting the generality of the foregoing, if Guarantied Party is awarded a
judgment in any suit brought to enforce any Guarantor’s covenant to pay a portion of the Guarantied Obligations, such judgment shall not be deemed to release such Guarantor from its covenant to pay the portion of the Guarantied Obligations that
is not the subject of such suit, and such judgment shall not, except to the extent satisfied by such Guarantor, limit, affect, modify or abridge any other Guarantor’s liability hereunder in respect of the Guarantied Obligations. 

(e) Any Beneficiary, upon such terms as it deems appropriate, without notice or demand and without affecting the validity
or enforceability of this Guaranty or giving rise to any reduction, limitation, impairment, discharge or termination of any Guarantor’s liability hereunder, from time to time may (i) renew, extend, accelerate, increase the rate of interest
on, or otherwise change the time, place, manner or terms of payment of the Guarantied Obligations, (ii) settle, compromise, release or discharge, or accept or refuse any offer of performance with respect to, or substitutions for, the Guarantied
Obligations or any agreement relating thereto and/or subordinate the payment of the same to the payment of any other obligations; (iii) request and accept other guaranties of the Guarantied Obligations and take and hold security for the payment
of this Guaranty or the Guarantied Obligations; (iv) release, surrender, exchange, substitute, compromise, settle, rescind, waive, alter, subordinate or modify, with or without consideration, any security for payment of the Guarantied
Obligations, any other guaranties of the Guarantied Obligations, or any other obligation of any Person (including any other Guarantor) with respect to the Guarantied Obligations; (v) enforce and apply any security now or hereafter held by or
for the benefit of such Beneficiary in respect of this Guaranty or the Guarantied Obligations and direct the order or manner of sale thereof, or exercise any other right or remedy that such Beneficiary may have against any such security, in each
case as such Beneficiary in its discretion may determine consistent with the Credit Agreement and any applicable security agreement, including foreclosure on any such security pursuant to one or more judicial or nonjudicial sales, whether or not
every aspect of any such sale is commercially reasonable, and even though such action operates to impair or extinguish any right of reimbursement or subrogation or other right or remedy of any Guarantor against Company or any security for the
Guarantied Obligations; and (vi) exercise any other rights available to it under the Loan Documents. 
 (f)
This Guaranty and the obligations of Guarantors hereunder shall be valid and enforceable and shall not be subject to any reduction, limitation, impairment, discharge or termination for any reason (other than payment in full of the Guarantied
Obligations), including the occurrence of any of the following, whether or not any Guarantor shall have had notice or knowledge of any of them: (i) any failure or omission to assert or enforce or agreement or election not to assert or enforce,
or the stay or enjoining, by order of court, by operation of law 

  
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or otherwise, of the exercise or enforcement of, any claim or demand or any right, power or remedy (whether arising under the Loan Documents, at law, in equity or otherwise) with respect to the
Guarantied Obligations or any agreement relating thereto, or with respect to any other guaranty of or security for the payment of the Guarantied Obligations; (ii) any rescission, waiver, amendment or modification of, or any consent to departure
from, any of the terms or provisions (including provisions relating to events of default) of the Credit Agreement, any of the other Loan Documents or any agreement or instrument executed pursuant thereto, or of any other guaranty or security for the
Guarantied Obligations, in each case whether or not in accordance with the terms of the Credit Agreement or such Loan Document or any agreement relating to such other guaranty or security; (iii) the Guarantied Obligations, or any agreement
relating thereto, at any time being found to be illegal, invalid or unenforceable in any respect; (iv) the application of payments received from any source (other than payments received pursuant to the other Loan Documents or from the proceeds
of any security for the Guarantied Obligations) to the payment of indebtedness other than the Guarantied Obligations, even though any Beneficiary might have elected to apply such payment to any part or all of the Guarantied Obligations; (v) any
Beneficiary’s consent to the change, reorganization or termination of the corporate structure or existence of Company or any of its Subsidiaries and to any corresponding restructuring of the Guarantied Obligations; (vi) any failure to
perfect or continue perfection of a security interest in any collateral which secures any of the Guarantied Obligations; (vii) any defenses, set-offs or counterclaims which Company may allege or assert against any Beneficiary in respect of the
Guarantied Obligations, including failure of consideration, breach of warranty, payment, statute of frauds, statute of limitations, accord and satisfaction and usury; and (viii) any other act or thing or omission, or delay to do any other act
or thing, which may or might in any manner or to any extent vary the risk of any Guarantor as an obligor in respect of the Guarantied Obligations. 
 2.5 Waivers by Guarantors. Each Guarantor hereby waives, for the benefit of Beneficiaries: 
 (a) any right to require any Beneficiary, as a condition of payment or performance by such Guarantor, to (i) proceed against Company, any other guarantor (including any other Guarantor) of the
Guarantied Obligations or any other Person, (ii) proceed against or exhaust any security held from Company, any such other guarantor or any other Person, (iii) proceed against or have resort to any balance of any deposit account or credit
on the books of any Beneficiary in favor of Company or any other Person, or (iv) pursue any other remedy in the power of any Beneficiary whatsoever; 
 (b) any defense arising by reason of the incapacity, lack of authority or any disability or other defense of Company including any defense based on or arising out of the lack of validity or the
unenforceability of the Guarantied Obligations or any agreement or instrument relating thereto or by reason of the cessation of the liability of Company from any cause other than payment in full of the Guarantied Obligations; 

  
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 (c) any defense based upon any statute or rule of law which provides that
the obligation of a surety must be neither larger in amount nor in other respects more burdensome than that of the principal; 
 (d) any defense based upon any Beneficiary’s errors or omissions in the administration of the Guarantied Obligations, except behavior which amounts to bad faith; 

(e) (i) any principles or provisions of law, statutory or otherwise, which are or might be in conflict with the terms
of this Guaranty and any legal or equitable discharge of such Guarantor’s obligations hereunder, (ii) the benefit of any statute of limitations affecting such Guarantor’s liability hereunder or the enforcement hereof, (iii) any
rights to set-offs, recoupments and counterclaims, and (iv) promptness, diligence and any requirement that any Beneficiary protect, secure, perfect or insure any security interest or lien or any property subject thereto; 

(f) notices, demands, presentments, protests, notices of protest, notices of dishonor and notices of any action or
inaction, including acceptance of this Guaranty, notices of default under the Credit Agreement or any agreement or instrument related thereto, notices of any renewal, extension or modification of the Guarantied Obligations or any agreement related
thereto, notices of any extension of credit to Company and notices of any of the matters referred to in subsection 2.4 and any right to consent to any thereof; and 

(g) any defenses or benefits that may be derived from or afforded by law which limit the liability of or exonerate
guarantors or sureties, or which may conflict with the terms of this Guaranty. 
 2.6 Guarantors’ Rights of
Subrogation, Contribution, Etc. Each Guarantor hereby waives, until the Guarantied Obligations shall have been indefeasibly paid in full and the Commitments shall have terminated and all Letters of Credit shall have expired or been
cancelled, any claim, right or remedy, direct or indirect, that such Guarantor now has or may hereafter have against Company or any of its assets in connection with this Guaranty or the performance by such Guarantor of its obligations hereunder, in
each case whether such claim, right or remedy arises in equity, under contract, by statute under common law or otherwise and including (a) any right of subrogation, reimbursement or indemnification that such Guarantor now has or may hereafter
have against Company, (b) any right to enforce, or to participate in, any claim, right or remedy that any Beneficiary now has or may hereafter have against Company, and (c) any benefit of, and any right to participate in, any collateral or
security now or hereafter held by any Beneficiary. In addition, until the Guarantied Obligations shall have been indefeasibly paid in full and the Commitments shall have terminated and all Letters of Credit shall have expired or been cancelled, each
Guarantor shall withhold 

  
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exercise of any right of contribution such Guarantor may have against any other guarantor (including any other Guarantor) of the Guarantied Obligations (including any such right of contribution
under subsection 2.2(b)). Each Guarantor further agrees that, to the extent the waiver or agreement to withhold the exercise of its rights of subrogation, reimbursement, indemnification and contribution as set forth herein is found by a court of
competent jurisdiction to be void or voidable for any reason, any rights of subrogation, reimbursement or indemnification such Guarantor may have against Company or against any collateral or security, and any rights of contribution such Guarantor
may have against any such other guarantor, shall be junior and subordinate to any rights any Beneficiary may have against Company, to all right, title and interest any Beneficiary may have in any such collateral or security, and to any right any
Beneficiary may have against such other guarantor. If any amount shall be paid to any Guarantor on account of any such subrogation, reimbursement, indemnification or contribution rights at any time when all Guarantied Obligations shall not have been
paid in full, such amount shall be held in trust for Guarantied Party on behalf of Beneficiaries and shall forthwith be paid over to Guarantied Party for the benefit of Beneficiaries to be credited and applied against the Guarantied Obligations,
whether matured or unmatured, in accordance with the terms hereof. 
 2.7 Subordination of Other Obligations. Any
indebtedness of Company or any Guarantor now or hereafter held by any Guarantor (the “Obligee Guarantor”) is hereby subordinated in right of payment to the Guarantied Obligations, and any such indebtedness collected or received by
the Obligee Guarantor after an Event of Default has occurred and is continuing shall be held in trust for Guarantied Party on behalf of Beneficiaries and shall forthwith be paid over to Guarantied Party for the benefit of Beneficiaries to be
credited and applied against the Guarantied Obligations but without affecting, impairing or limiting in any manner the liability of the Obligee Guarantor under any other provision of this Guaranty. 

2.8 Expenses. Guarantors jointly and severally agree to pay, or cause to be paid, on demand, and to save Beneficiaries
harmless against liability for, any and all costs and expenses (including reasonable fees and disbursements of counsel and reasonable allocated costs of internal counsel) incurred or expended by any Beneficiary in connection with the enforcement of
or preservation of any rights under this Guaranty. 
 2.9 Continuing Guaranty. This Guaranty is a continuing
guaranty and shall remain in effect until all of the Guarantied Obligations shall have been paid in full and the Commitments shall have terminated and all Letters of Credit shall have expired or been cancelled. Each Guarantor hereby irrevocably
waives any right to revoke this Guaranty as to future transactions giving rise to any Guarantied Obligations. 
 2.10
Rights Cumulative. The rights, powers and remedies given to Beneficiaries by this Guaranty are cumulative and shall be in addition to and independent of all rights, powers and remedies given to Beneficiaries by virtue of any statute or
rule of law or in any of the other Loan Documents or any agreement between any Guarantor and any Beneficiary or Beneficiaries or between Company and any Beneficiary or Beneficiaries. Any forbearance or failure to exercise, and any delay by any
Beneficiary in exercising, any right, power or remedy hereunder shall not impair any such right, power or remedy or be construed to be a waiver thereof, nor shall it preclude the further exercise of any such right, power or remedy. 

  
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 2.11 Bankruptcy; Post-Petition Interest; Reinstatement of Guaranty.
(a) So long as any Guarantied Obligations remain outstanding, no Guarantor shall, without the prior written consent of Guarantied Party acting pursuant to the instructions of Requisite Lenders, commence or join with any other Person in
commencing any bankruptcy, reorganization or insolvency proceedings of or against Company. The obligations of Guarantors under this Guaranty shall not be reduced, limited, impaired, discharged, deferred, suspended or terminated by any proceeding,
voluntary or involuntary, involving the bankruptcy, insolvency, receivership, reorganization, liquidation or arrangement of Company or by any defense which Company may have by reason of the order, decree or decision of any court or administrative
body resulting from any such proceeding. 
 (b) Each Guarantor acknowledges and agrees that any interest on any portion of the
Guarantied Obligations which accrues after the commencement of any proceeding referred to in clause (a) above (or, if interest on any portion of the Guarantied Obligations ceases to accrue by operation of law by reason of the commencement of
said proceeding, such interest as would have accrued on such portion of the Guarantied Obligations if said proceedings had not been commenced) shall be included in the Guarantied Obligations because it is the intention of Guarantors and
Beneficiaries that the Guarantied Obligations which are guarantied by Guarantors pursuant to this Guaranty should be determined without regard to any rule of law or order which may relieve Company of any portion of such Guarantied Obligations.
Guarantors will permit any trustee in bankruptcy, receiver, debtor in possession, assignee for the benefit of creditors or similar person to pay Guarantied Party, or allow the claim of Guarantied Party in respect of, any such interest accruing after
the date on which such proceeding is commenced. 
 (c) In the event that all or any portion of the Guarantied Obligations are
paid by Company, the obligations of Guarantors hereunder shall continue and remain in full force and effect or be reinstated, as the case may be, in the event that all or any part of such payment(s) are rescinded or recovered directly or indirectly
from any Beneficiary as a preference, fraudulent transfer or otherwise, and any such payments which are so rescinded or recovered shall constitute Guarantied Obligations for all purposes under this Guaranty. 

2.12 Notice of Events. As soon as Guarantor obtains knowledge thereof, Guarantor shall give Guarantied Party written notice
of any condition or event which has resulted in (a) a material adverse change in the financial condition of Guarantor or Company or (b) any Event of Default or Potential Event of Default. 

  
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 2.13 Set Off. In addition to any other rights any Beneficiary may have under
law or under this Guaranty, such Beneficiary is authorized at any time or from time to time while an Event of Default has occurred and is continuing, without notice (any such notice being hereby expressly waived), to set off and to appropriate and
to apply any and all deposits (general or special, including indebtedness evidenced by certificates of deposit, whether matured or unmatured) and any other indebtedness of such Beneficiary owing to Guarantor and any other property of Guarantor held
by any Beneficiary to or for the credit or the account of Guarantor against and on account of the Guarantied Obligations and liabilities of Guarantor to any Beneficiary under this Guaranty. 

2.14 Representations and Warranties. Each Guarantor represents and warrants as to itself, on the date that it becomes a
party hereto, on the Term Loan Funding Date, on each Funding Date (other than, in the case of Funding Dates occurring after the Term Loan Funding Date, subsections 5.4 and 5.6 of the Credit Agreement) and on the date of the issuance of each Letter
of Credit (other than, in the case of Funding Dates occurring after the Term Loan Funding Date, subsections 5.4 and 5.6 of the Credit Agreement) that all representations and warranties relating to it contained in the Loan Documents are true, correct
and complete in all material respects, except to the extent such representations and warranties specifically relate to an earlier date, in which case such representations and warranties were true, correct and complete in all material respects on and
as of such earlier date. 
 2.15 Covenants. Each Guarantor covenants and agrees that such Guarantor will perform
and observe, and cause each of its Subsidiaries to perform and observe, all of the terms, covenants and agreements set forth in the Loan Documents that are required to be, or that Company has agreed to cause to be, performed or observed by such
Guarantor or Subsidiary. 
 2.16 Information. Each Guarantor assumes all responsibility for
being and keeping itself informed of the Company’s and each other Loan Party’s financial condition and assets and of all other circumstances bearing upon the risk of nonpayment of the Guaranteed Obligations and the nature, scope and extent
of the risks that such Guarantor assumes and incurs hereunder, and agrees that neither the Guarantied Party nor any other Beneficiary will have any duty to advise such Guarantor of information known to it or any of them regarding such circumstances
or risks. 
 SECTION 3. MISCELLANEOUS 
 3.1 Survival of Warranties. All agreements, representations and warranties made herein shall survive the execution and delivery of this Guaranty and the other Loan Documents and any increase
in the Commitments under the Credit Agreement. 
 3.2 Notices. Any communications between Guarantied Party and any
Guarantor and any notices or requests provided herein to be given may be given by mailing the same, postage prepaid, or by telex, facsimile transmission or cable to each such party at its address set forth in the Credit Agreement, on the signature
pages hereof or to such other addresses as each such party may in writing hereafter indicate. Any notice, request or demand to or upon Guarantied Party or any Guarantor shall not be effective until received. 

  
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 3.3 Severability. In case any provision in or obligation under this Guaranty
shall be invalid, illegal or unenforceable in any jurisdiction, the validity, legality and enforceability of the remaining provisions or obligations, or of such provision or obligation in any other jurisdiction, shall not in any way be affected or
impaired thereby. 
 3.4 Amendments and Waivers. (a) No failure or delay by the Guarantied Party or any other
Beneficiary in exercising any right or power hereunder or under any other Loan Document shall operate as a waiver hereof or thereof, nor shall any single or partial exercise of any such right or power, or any abandonment or discontinuance of steps
to enforce such a right or power, preclude any other or further exercise thereof or the exercise of any other right or power. The rights and remedies of the Guarantied Party and the other Beneficiaries hereunder and under the other Loan Documents
are cumulative and are not exclusive of any rights or remedies that they would otherwise have. No waiver of any provision of any Loan Document or consent to any departure by any Loan Party therefrom shall in any event be effective unless the same
shall be permitted by paragraph (b) of this Section 3.4 and then such waiver or consent shall be effective only in the specific instance and for the purpose for which given. No notice or demand on any Loan Party in any case shall entitle
any Loan Party to any other or further notice or demand in similar or other circumstances. 
 (b) No amendment, modification,
termination or waiver of any provision of this Guaranty, and no consent to any departure by any Guarantor therefrom, shall in any event be effective without the written concurrence of Guarantied Party and, in the case of any such amendment or
modification, each Guarantor against whom enforcement of such amendment or modification is sought. Any such waiver or consent shall be effective only in the specific instance and for the specific purpose for which it was given. Any amendment,
modification, termination, waiver or consent effected in accordance with this subsection 3.4(b) shall be binding upon each Beneficiary. 
 3.5 Headings. Section and subsection headings in this Guaranty are included herein for convenience of reference only and shall not constitute a part of this Guaranty for any other purpose or
be given any substantive effect. 
 3.6 Applicable Law; Rules of Construction. THIS GUARANTY AND THE RIGHTS AND
OBLIGATIONS OF GUARANTORS AND BENEFICIARIES HEREUNDER SHALL BE GOVERNED BY, AND SHALL BE CONSTRUED AND ENFORCED IN ACCORDANCE WITH, THE INTERNAL LAWS OF THE STATE OF NEW YORK. The rules of construction set forth in subsection 1.3 of the Credit
Agreement shall be applicable to this Guaranty mutatis mutandis. 
 3.7 Successors and Assigns. This
Guaranty is a continuing guaranty and shall be binding upon each Guarantor and its respective successors and assigns. This Guaranty shall inure to the benefit of Beneficiaries and their respective successors and assigns. No Guarantor shall assign
this Guaranty or any of the rights or obligations of such Guarantor hereunder without the prior written consent of all Lenders. Any 

  
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Beneficiary may, without notice or consent, assign its interest in this Guaranty in whole or in part. The terms and provisions of this Guaranty shall inure to the benefit of any transferee or
assignee of any Loan, and in the event of such transfer or assignment the rights and privileges herein conferred upon such Beneficiary shall automatically extend to and be vested in such transferee or assignee, all subject to the terms and
conditions hereof. 
 3.8 Consent to Jurisdiction and Service of Process. ALL JUDICIAL PROCEEDINGS BROUGHT
AGAINST ANY GUARANTOR ARISING OUT OF OR RELATING TO THIS GUARANTY, OR ANY OBLIGATIONS HEREUNDER, MAY BE BROUGHT IN ANY STATE OR FEDERAL COURT OF COMPETENT JURISDICTION IN THE STATE, COUNTY AND CITY OF NEW YORK. BY EXECUTING AND DELIVERING THIS
AGREEMENT, EACH GUARANTOR, FOR ITSELF AND IN CONNECTION WITH ITS PROPERTIES, IRREVOCABLY 
 (I) ACCEPTS
GENERALLY AND UNCONDITIONALLY THE NONEXCLUSIVE JURISDICTION AND VENUE OF SUCH COURTS; 
 (II) WAIVES ANY
DEFENSE OF FORUM NON CONVENIENS WITH RESPECT TO ANY STATE OR FEDERAL COURT OF COMPETENT JURISDICTION IN THE STATE, COUNTY AND CITY OF NEW YORK; 
 (III) AGREES THAT SERVICE OF ALL PROCESS IN ANY SUCH PROCEEDING IN ANY SUCH COURT MAY BE MADE BY REGISTERED OR CERTIFIED MAIL, RETURN RECEIPT REQUESTED, TO SUCH GUARANTOR AT ITS ADDRESS PROVIDED IN
ACCORDANCE WITH SUBSECTION 3.2; 
 (IV) AGREES THAT SERVICE AS PROVIDED IN CLAUSE (III) ABOVE IS
SUFFICIENT TO CONFER PERSONAL JURISDICTION OVER SUCH GUARANTOR IN ANY SUCH PROCEEDING IN ANY SUCH COURT, AND OTHERWISE CONSTITUTES EFFECTIVE AND BINDING SERVICE IN EVERY RESPECT; 

(V) AGREES THAT BENEFICIARIES RETAIN THE RIGHT TO SERVE PROCESS IN ANY OTHER MANNER PERMITTED BY LAW OR TO BRING
PROCEEDINGS AGAINST SUCH GUARANTOR IN THE COURTS OF ANY OTHER JURISDICTION; AND 
 (VI) AGREES THAT THE
PROVISIONS OF THIS SUBSECTION 3.8 RELATING TO JURISDICTION AND VENUE SHALL BE BINDING AND ENFORCEABLE TO THE FULLEST EXTENT PERMISSIBLE UNDER NEW YORK GENERAL OBLIGATIONS LAW SECTION 5-1402 OR OTHERWISE. 

  
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 3.9 Waiver of Trial by Jury. EACH GUARANTOR AND, BY ITS ACCEPTANCE OF THE
BENEFITS HEREOF, EACH BENEFICIARY HEREBY AGREES TO WAIVE ITS RESPECTIVE RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS GUARANTY. The scope of this waiver is intended to be all encompassing of any and all
disputes that may be filed in any court and that relate to the subject matter of this transaction, including contract claims, tort claims, breach of duty claims and all other common law and statutory claims. Each Guarantor and, by its acceptance of
the benefits hereof, each Beneficiary, each (i) acknowledges that this waiver is a material inducement for such Guarantor and Beneficiaries to enter into a business relationship, that such Guarantor and Beneficiaries have already relied on this
waiver in entering into this Guaranty or accepting the benefits thereof, as the case may be, and that each will continue to rely on this waiver in their related future dealings and (ii) further warrants and represents that each has reviewed
this waiver with its legal counsel, and that each knowingly and voluntarily waives its jury trial rights following consultation with legal counsel. THIS WAIVER IS IRREVOCABLE, MEANING THAT IT MAY NOT BE MODIFIED EITHER ORALLY OR IN WRITING (OTHER
THAN BY A MUTUAL WRITTEN WAIVER SPECIFICALLY REFERRING TO THIS SUBSECTION 3.9 AND EXECUTED BY GUARANTIED PARTY AND EACH GUARANTOR), AND THIS WAIVER SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS GUARANTY. In
the event of litigation, this Guaranty may be filed as a written consent to a trial by the court. 
 3.10 No Other
Writing. This writing is intended by Guarantors and Beneficiaries as the final expression of this Guaranty and is also intended as a complete and exclusive statement of the terms of their agreement with respect to the matters covered hereby.
No course of dealing, course of performance or trade usage, and no parol evidence of any nature, shall be used to supplement or modify any terms of this Guaranty. There are no conditions to the full effectiveness of this Guaranty. 

3.11 Further Assurances. At any time or from time to time, upon the request of Guarantied Party, Guarantors shall execute
and deliver such further documents and do such other acts and things as Guarantied Party may reasonably request in order to effect fully the purposes of this Guaranty. 
 3.12 Additional Guarantors. The initial Guarantors hereunder shall be such of the Domestic Subsidiaries of Company as are signatories hereto on the date hereof. From time to time subsequent
to the date hereof, additional Domestic Subsidiaries of Company may become parties hereto, as additional Guarantors (each an “Additional Guarantor”), by executing a counterpart of this Guaranty. Upon delivery of any such counterpart
to Administrative Agent, notice of which is hereby waived by Guarantors, each such Additional Guarantor shall be a Guarantor and shall be as fully a party hereto as if such Additional Guarantor were an original signatory hereof. Each Guarantor
expressly agrees that its obligations arising hereunder shall not be affected or diminished by the addition or release of any other Guarantor hereunder, nor by any election of Administrative Agent not to cause any Subsidiary of Company to become an
Additional Guarantor hereunder. This Guaranty shall be fully effective as to any Guarantor that is or becomes a party hereto regardless of whether any other Person becomes or fails to become or ceases to be a Guarantor hereunder. 

  
 -13-

 3.13 Counterparts; Effectiveness. This Guaranty may be executed in any number
of counterparts and by the different parties hereto in separate counterparts, each of which when so executed and delivered shall be deemed to be an original for all purposes; but all such counterparts together shall constitute but one and the same
instrument. This Guaranty shall become effective as to each Guarantor upon the execution of a counterpart hereof by such Guarantor (whether or not a counterpart hereof shall have been executed by any other Guarantor) and receipt by Guarantied Party
of written or telephonic notification of such execution and authorization of delivery thereof. Delivery of an executed counterpart of a signature page of this Guaranty by telefacsimile or electronic transmission (in PDF format) shall be effective as
delivery of a manually executed counterpart of this Guaranty. 
 3.14 Guarantied Party as Agent. 

(a) Guarantied Party has been appointed to act as Guarantied Party hereunder by Lenders. Guarantied Party shall be obligated, and shall
have the right hereunder, to make demands, to give notices, to exercise or refrain from exercising any rights, and to take or refrain from taking any action, solely in accordance with this Guaranty and the Credit Agreement; provided that
Guarantied Party shall exercise, or refrain from exercising, any remedies hereunder in accordance with the instructions of Requisite Lenders. 
 (b) Guarantied Party shall at all times be the same Person that is Administrative Agent under the Credit Agreement. Written notice of resignation by Administrative Agent pursuant to subsection 9.5 of the
Credit Agreement shall also constitute notice of resignation as Guarantied Party under this Guaranty; removal of Administrative Agent under the Credit Agreement shall also constitute removal as Guarantied Party under this Guaranty; and appointment
of a successor Agent pursuant to subsection 9.5 of the Credit Agreement shall also constitute appointment of a successor Guarantied Party under this Guaranty. Upon the acceptance of any appointment as Administrative Agent under subsection 9.5 of the
Credit Agreement by a successor Administrative Agent, that successor Administrative Agent shall thereupon succeed to and become vested with all the rights, powers, privileges and duties of the resigning or removed Guarantied Party under this
Guaranty, and the resigning or removed Guarantied Party under this Guaranty shall promptly (i) transfer to such successor Guarantied Party all sums held hereunder, together with all records and other documents necessary or appropriate in
connection with the performance of the duties of the successor Guarantied Party under this Guaranty, and (ii) take such other actions as may be necessary or appropriate in connection with the assignment to such successor Guarantied Party of the
rights created hereunder, whereupon such retiring or removed Guarantied Party shall be discharged from its duties and obligations under this Guaranty. After any retiring or removed Guarantied Party’s resignation or removal hereunder as
Guarantied Party, the provisions of this Guaranty shall inure to its benefit as to any actions taken or omitted to be taken by it under this Guaranty while it was Guarantied Party hereunder. 

  
 -14-

 3.15 Release of Guarantors. A Guarantor shall automatically be released from
its Guarantied Obligations upon the consummation of any transaction permitted by the Credit Agreement as a result of which such Guarantor ceases to be a Domestic Subsidiary; provided that, if so required by the Credit Agreement, the Requisite
Lenders shall have consented to such transaction and the terms of such consent shall not have provided otherwise. 

  
 -15-

 IN WITNESS WHEREOF, each of the undersigned Guarantors has caused this Guaranty to be
duly executed and delivered by its officer thereunto duly authorized as of the date first written above. 
  

			
	
	 AIRPORT HOLDINGS, LLC
 ESI REALTY, LLC

	
	By : Express Scripts, Inc., as sole Member
		
	By:	 	/s/ Keith J. Ebling
		 	 Name: Keith J. Ebling

Title: Vice President

 [Subsidiary Guaranty] 

			
	 BYFIELD DRUG, INC.
 CARE CONTINUUM, INC.
 CFI OF NEW JERSEY, INC.

CHESAPEAKE INFUSION, INC.

CONNECTYOURCARE
 COMPANY
LLC
 CONNECTYOURCARE, LLC

CURASCRIPT PBM SERVICES,

INC.
 DIVERSIFIED

PHARMACEUTICAL
 SERVICES,
INC.
 ESI ACQUISITION, INC.

ESI CLAIMS, INC.
 ESI ENTERPRISES,
LLC
 ESI MAIL ORDER

PROCESSING, INC.
 EXPRESS SCRIPTS
CANADA
 HOLDING CO.

EXPRESS SCRIPTS CANADA
 HOLDING,
LLC
 EXPRESS SCRIPTS, INC.

EXPRESS SCRIPTS

PHARMACEUTICAL
 PROCUREMENT,
LLC
 EXPRESS SCRIPTS SERVICES

COMPANY
 FRECO, INC.

FREEDOM SERVICE
 COMPANY,
LLC
 HEALTHBRIDGE, INC.

HEALTHBRIDGE
 REIMBURSEMENT
AND
 PRODUCT SUPPORT, INC.

IBIOLOGIC, INC.
 IVTX,
INC.
 LYNNFIELD COMPOUNDING

CENTER, INC.
 LYNNFIELD DRUG,
INC.
 MATRIX GPO LLC

NATIONAL PRESCRIPTION ADMINISTRATORS, INC. PRIORITYHEALTHCARE.COM, INC.
 PRIORITY HEALTHCARE

 [Subsidiary Guaranty] 

 
			
	 CORPORATION

PRIORITY HEALTHCARE
 CORPORATION
WEST
 PRIORITY HEALTHCARE

DISTRIBUTION, INC.
 PRIORITY
HEALTHCARE
 PHARMACY, INC.

SINUSPHARMACY, INC.
 SPECIALTY
INFUSION
 PHARMACY, INC.

SPECTRACARE, INC.
 SPECTRACARE
HEALTH
 CARE VENTURES, INC.

SPECTRACARE INFUSION
 PHARMACY,
INC.
 VALUE HEALTH, INC.

YOURPHARMACY.COM, INC.

		
	By:	 	/s/ Keith J. Ebling
		 	 Name: Keith J. Ebling

Title: Vice President

  
 [Subsidiary Guaranty]

 
	
	 EXPRESS SCRIPTS MSA, LLC
 EXPRESS SCRIPTS WC, INC.

	EXPRESS SCRIPTS SENIOR CARE, INC.
	EXPRESS SCRIPTS SENIOR CARE HOLDINGS, INC.
	CURASCRIPT, INC.
	EXPRESS SCRIPTS UTILIZATION MANAGEMENT CO.
	
	 By: /s/ Martin P.
Akins                                        
                                        

       Name: Martin P. Akins
       Title: Assistant Secretary

	
	ESI MAIL PHARMACY SERVICE, INC.
	 EXPRESS SCRIPTS SPECIALTY DISTRIBUTION SERVICES, INC.

MOORESVILLE ON-SITE PHARMACY, LLC

	
	 By: /s/ Martin P.
Akins                                        
                                        

       Name: Martin P. Akins
       Title: Secretary

 [Subsidiary Guaranty] 

 
	
	SPECTRACARE OF INDIANA
	
	By: Spectracare, Inc., as Partner
	
	 By: /s/ Keith J.
Ebling                                        
        
       Name: Keith J. Ebling

      Title: Vice President

	
	By: Care Continuum, Inc., as Partner
	
	 By: /s/ Keith J.
Ebling                                        
        
       Name: Keith J. Ebling

      Title: Vice President

 [Subsidiary Guaranty] 

 
	
	ESI RESOURCES, INC.
	ESI-GP HOLDINGS, INC.
	
	By: /s/ Tom
Rocheford                                        
      
	      Name: Tom Rocheford
	      Title: President
	
	ESI PARTNERSHIP
	
	By: Express Scripts, Inc., as Partner
	
	By: /s/ Keith
J.Ebling                                        
        
	      Name: Keith J.Ebling
	      Title: Vice President
	
	By: ESI-GP Holdings, Inc., as Partner
	
	By: /s/ Tom Rocheford
                                         
       
	      Name: Tom Rocheford
	      Title: President

 [Subsidiary Guaranty] 

 
	
	ACCREDO HEALTH, INCORPORATED
	ACCREDO HEALTH GROUP, INC.
	MEDCO HEALTH SERVICES, INC.
	MEDCO HEALTH SOLUTIONS, INC.
	
	 By: /s/ Keith J.
Ebling                                        
      
       Name: Keith J. Ebling

      Title: Vice President

 [Subsidiary Guaranty] 

 IN WITNESS WHEREOF, the undersigned Additional Guarantor has caused this Guaranty to
be duly executed and delivered by its officer thereunto duly authorized as of May 29, 2012. 
  

	
	ACCREDO CARE NETWORK, INC.
	AHG OF NEW YORK, INC.
	BIOPARTNERS IN CARE, INC.
	BRACKET GLOBAL, LLC
	CCS INFUSION MANAGEMENT, LLC
	CCSI HOLDING 3, LLC
	CRITICAL CARE SYSTEMS OF NEW YORK, INC.
	CRITICAL CARE SYSTEMS, INC.
	DNA DIRECT, INC.
	ENVISION PHARMA INC.
	EVIDENCE SCIENTIFIC SOLUTIONS, INC.
	HIDDEN RIVER, L.L.C.
	HOME HEALTHCARE RESOURCES, INC.
	INFINITY INFUSION II, LLC
	INFINITY INFUSION, LLC
	INSTITUTE FOR MEDICAL EDUCATION & RESEARCH, INC.
	LIBERTY HEALTHCARE GROUP, INC.
	LIBERTY HEALTHCARE PHARMACY OF NEVADA, LLC
	LIBERTY LANE DEVELOPMENT COMPANY, INC.
	LIBERTY MARKETPLACE, INC.
	LIBERTY MEDICAL SUPPLY, INC.
	MAH PHARMACY, L.L.C.
	MAH PROCESSING, INC.
	MEDCO AT HOME, L.L.C.
	MEDCO CDUR, L.L.C.
	MEDCO CHP, L.L.C.

 [Subsidiary Guaranty Counterpart] 

 
MEDCO CONTINUATION 
 HEALTH, L.L.C. 

MEDCO EUROPE, L.L.C. 
 MEDCO EUROPE II, L.L.C. 
 MEDCO HEALTH, L.L.C. 

MEDCO HEALTH NEW YORK 
 INDEPENDENT PRACTICE 
 ASSOCIATION, L.L.C. 

MEDCO HEALTH PUERTO 
 RICO, L.L.C. 
 MEDCO HEALTH SOLUTIONS 

OF COLUMBUS NORTH, LTD. 
 MEDCO HEALTH SOLUTIONS 
 OF COLUMBUS WEST, LTD. 

MEDCO HEALTH SOLUTIONS 
 OF FAIRFIELD, L.L.C. 
 MEDCO HEALTH SOLUTIONS 

OF FRANKLIN LAKES, L.L.C. 
 MEDCO HEALTH SOLUTIONS 
 OF HENDERSON, NEVADA, L.L.C. 

MEDCO HEALTH SOLUTIONS 
 OF HIDDEN RIVER, L.C. 
 MEDCO HEALTH SOLUTIONS 

OF ILLINOIS, L.L.C. 
 MEDCO HEALTH SOLUTIONS 
 OF INDIANA, L.L.C. 

MEDCO HEALTH SOLUTIONS 
 OF IRVING, L.L.C. 
 MEDCO HEALTH SOLUTIONS 

OF LAS VEGAS, L.L.C. 
 MEDCO HEALTH SOLUTIONS 
 OF NETPARK, L.L.C. 

MEDCO HEALTH SOLUTIONS 
 OF NORTH VERSAILLES, L.L.C. 
 MEDCO HEALTH SOLUTIONS 

OF RICHMOND, L.L.C. 
 MEDCO HEALTH SOLUTIONS 
 OF SPOKANE, L.L.C. 

MEDCO HEALTH SOLUTIONS 
 OF TEXAS, L.L.C. 
 MEDCO HEALTH SOLUTIONS 

OF WILLINGBORO, L.L.C. 
 MEDCOHEALTH.COM, L.L.C. 
 MEDCO OF WILLINGBORO 

[Subsidiary Guaranty Counterpart] 

 
			
	 URBAN RENEWAL, L.L.C.
 MEDCO RESEARCH
 INSTITUTE, L.L.C.

NATIONAL DIABETIC
 MEDICAL SUPPLY,
L.L.C.
 NATIONAL RX SERVICES NO.
 3, INC. OF OHIO
 P-STAR ACQUISITION CO.,

INC.
 POLYMEDICA
CORPORATION
 SYSTEMED, L.L.C.

THE VACCINE CONSORTIUM,

LLC
 THERAPEASE CUISINE,
INC.
 TVC ACQUISITION CO., INC.
 UBC HEALTH CARE ANALYTICS,
 INC.

UBC LATE STAGE,
 INC.

UBC SCIENTIFIC SOLUTIONS,

INC.
 UNITED BIOSOURCE

CORPORATION
 UNITED BIOSOURCE
PATIENT
 SOLUTIONS, INC.

		
	By:	 	/s/ Keith J. Ebling
		 	 Name: Keith J. Ebling

Title: Vice President

		
	Address:	 	 One Express Way
 St. Louis,
Missouri 63121

	
	 INFINITY INFUSION CARE, LTD.
  

By: Infinity Infusion, LLC, as Partner

  

			
		
	By:	 	/s/ Keith J. Ebling
		 	 Name: Keith J. Ebling

Title: Vice President

 [Subsidiary Guaranty Counterpart] 

 
			
	
	By: Infinity Infusion II, LLC, as Partner
		
	By:	 	/s/ Keith J. Ebling
		 	 Name: Keith J. Ebling

Title: Vice President

		
	Address:	 	 One Express Way
 St. Louis,
Missouri 63121

 [Subsidiary Guaranty Counterpart]

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