Document:

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                             SUBSCRIPTION AGREEMENT

         This Subscription Agreement (the "Agreement") is made and entered into
as of April 4, 2000 by and among Trega Biosciences, Inc., a Delaware corporation
(the "Company"), and those parties listed on the signature page hereof as
"Investors" (who are referred to individually as an "Investor" and collectively
as the "Investors").

         In consideration of the above recitals and the mutual covenants made
herein, the parties hereby agree as follows:

         1.       SALE OF COMMON STOCK; CLOSING; DELIVERY.

                  (a) PURCHASE AND SALE OF COMMON STOCK. Subject to the terms
and conditions hereof, the Company will issue and sell to each Investor, and
each Investor will purchase from the Company, at the Closing (as defined below)
the number of shares ("Shares") of common stock, $0.001 par value, ("Common
Stock") of the Company, set forth opposite each Investor's name on Exhibit A.
The Company is offering for sale on a "best efforts" basis, a minimum of
2,500,000 Shares at $3.00 a Share for a purchase price of $7,500,000 (the
"Minimum Offering Amount"), up to a maximum of 3,900,000 Shares at $3.00 a share
for a purchase price of $11,700,000 (the "Maximum Offering Amount").

                  (b) ESCROW. All funds received from investors and accepted by
the Company will be deposited into an escrow account with Imperial Bank (the
"Escrow Account"). The escrow agreement provides that funds may be released from
the Escrow Account only upon the satisfaction of certain conditions, including
the deposit of at least the Minimum Offering Amount in the Escrow Account on or
before March 31, 2000; (the "Initial Closing") provided, however, that the
Initial Closing may be extended to April 7, 2000 by the Company, and may be
further extended to April 14, 2000 by the mutual consent of First Security Van
Kasper (the "Placement Agent") and the Company. All payments received by the
Escrow Agent prior to the Initial Closing shall be held in a trust account for
the benefit of the Investors pending Initial Closing.

                  (c) CLOSING. Subject to the deposit of the Minimum Offering
Amount in the Escrow Account, the Initial Closing shall take place at the
offices of counsel for the Company at Pillsbury Madison & Sutro, 50 Fremont
Street, San Francisco, California at 10:00 a.m., PDT, or such other time(s) and
place(s) as the Company and the Placement Agent shall agree; provided, however,
that the Initial Closing shall take place on or before April 7, 2000, unless
extended by mutual consent of the Company and the Placement Agent to no later
than April 14, 2000. In the event that additional funds are raised subsequent to
the Initial Closing, one or more later closings may be held until the Maximum
Offering Amount of Shares is sold or until April 14, 2000. The Initial Closing
and the date any subsequent closings are hereinafter referred to as the
"Closing".

                  (d) DELIVERY. Subject to the terms and conditions of this
Agreement, at each Closing, the Company will deliver to each Investor a stock
certificate representing the

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Shares to be purchased by such Investor against payment of the purchase price
therefor by a check, payable to the order of the Company, or by wire transfer of
immediately available funds submitted to the Escrow Account in accordance with
instructions to be provided to the Investors by the Placement Agent.

         2. REPRESENTATIONS AND WARRANTIES OF INVESTORS. Each Investor
represents and warrants, severally, to the Company that:

                  (a) AUTHORIZATION. This Agreement constitutes the valid and
legally binding obligation of such Investor, enforceable in accordance with its
terms, except as such enforcement may be limited by bankruptcy, insolvency and
similar laws affecting the enforcement of creditors' rights generally and
equitable remedies, and except as indemnity provisions in the enforcement of
Section 4 of this Agreement (relating to registration rights) may be limited by
law, and such Investor (if an individual) is over 18 years of age, and such
Investor has full legal capacity, power and authority to enter into and be bound
by this Agreement.

                  (b) PURCHASE FOR OWN ACCOUNT FOR INVESTMENT. Such Investor is
purchasing the Shares for investment purposes only and not with a view to, or
for sale in connection with, a distribution of the Shares within the meaning of
the Securities Act of 1933, as amended (the "Securities Act"). Such Investor has
no present intention of selling or otherwise disposing of all or any portion of
the Shares.

                  (c) ACCESS TO INFORMATION. Such Investor has had an
opportunity to ask questions of the Company's representatives concerning the
Company, its present and prospective business, assets, liabilities and financial
condition that such Investor reasonably considers important in making the
decision to purchase the Shares.

                  (d) UNDERSTANDING OF RISKS. Such Investor is fully aware of:
(i) the highly speculative nature of the investment in the Shares; (ii) the
financial hazards involved; (iii) the lack of liquidity of the Shares, and the
restrictions on the transferability of the Shares, (e.g., that such Investor may
not be able to sell or dispose of the Shares, or use them as collateral for
loans); and (iv) the tax consequences of investment in the Shares.

                  (e) INVESTOR'S QUALIFICATIONS. Such Investor is an
"accredited" investor as defined under Rule 501 of Regulation D promulgated
under the Securities Act. Such Investor is aware of the general business and
financial circumstances of the Company and, by reason of such Investor's
business or financial experience, such Investor is capable of evaluating the
merits and risks of this investment and is financially capable of bearing a
total loss of this investment.

                  (f) COMPLIANCE WITH SECURITIES LAWS. Such Investor understands
and acknowledges that, in reliance upon the representations and warranties made
by such Investor herein, the Shares are not being registered with the U.S.
Securities and Exchange Commission ("SEC" or "Commission") under the Securities
Act, but instead are being issued under an exemption from the registration
requirements of the Securities Act.

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                  (g) RESTRICTIONS ON TRANSFER. Such Investor understands that
such Investor may not transfer any of the Shares, unless such Shares, are
registered under the Securities Act unless, in the opinion of counsel to the
Company, an exemption from such registration requirement is available. Such
Investor understands that only the Company may file a registration statement
with the SEC. Such Investor has also been advised that an exemption from
registration may not be available or may not permit such Investor to transfer
all or any of the Shares in the amounts or at the times proposed by such
Investor.

                  (h) RULE 144. In addition, such Investor has been advised that
SEC Rule 144 ("Rule 144") promulgated under the Securities Act, which permits
certain limited sales of unregistered securities is not presently available due
to the holding periods required thereunder and, in any event, requires that the
Shares be held for a minimum of one year, and in certain cases two years, after
they have been purchased and paid for (within the meaning of Rule 144), before
they may be resold under Rule 144. Such Investor understands that Rule 144 may
indefinitely restrict transfer of the Shares if such Investor is an "affiliate"
of the Company and "current public information" about the Company (as defined in
Rule 144) is not publicly available.

                  (i) LEGENDS AND STOP-TRANSFER ORDERS. Such Investor
understands that certificates or other instruments representing any of the
Shares acquired by such Investor may bear legends substantially similar to the
following, in addition to any other legends required by federal or state laws:

         THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE
         SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR UNDER THE SECURITIES
         LAWS OF CERTAIN STATES. THESE SECURITIES ARE SUBJECT TO RESTRICTIONS ON
         TRANSFERABILITY AND RESALE AND MAY NOT BE TRANSFERRED OR RESOLD EXCEPT
         AS PERMITTED UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS,
         PURSUANT TO REGISTRATION OR EXEMPTION THEREFROM. THE ISSUER OF THESE
         SECURITIES MAY REQUIRE AN OPINION OF COUNSEL IN FORM AND SUBSTANCE
         SATISFACTORY TO THE ISSUER TO THE EFFECT THAT ANY PROPOSED TRANSFER OR
         RESALE IS IN COMPLIANCE WITH THE ACT AND ANY APPLICABLE STATE
         SECURITIES LAWS UNLESS SOLD PURSUANT TO AN EFFECTIVE REGISTRATION
         STATEMENT.

         In order to ensure and enforce compliance with the restrictions imposed
by applicable law and those referred to in the foregoing legend, or elsewhere
herein, the Company may issue appropriate "stop transfer" instructions to its
transfer agent, if any, with respect to any certificate or other instrument
representing the Shares, or if the Company transfers its own securities, it may
make appropriate notations to the same effect in the Company's records. Any
legend endorsed on a certificate pursuant to this Subsection (i) and the related
stop transfer instructions with respect to such securities shall be removed, and
the Company shall issue a certificate without such legend to the holder thereof,
if such securities are registered

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under the Securities Act and a prospectus meeting the requirements of Section 10
of the Securities Act is available, if such legend may be properly removed under
the terms of Rule 144 promulgated under the Securities Act or if such holder
provides the Company with an opinion of counsel for such holder, reasonably
satisfactory to legal counsel for the Company, to the effect that a sale,
transfer or assignment of such securities may be made without registration.

                  (j) RESTRICTION ON SALES, SHORT SALES AND HEDGING
TRANSACTIONS. Such Investor will not, prior to the effectiveness of the
registration statement to be filed pursuant to Section 4 of this Agreement,
sell, offer to sell, solicit offers to buy, dispose of, loan, pledge, or grant
any right with respect to (collectively, a "Disposition") the Common Stock of
the Company, nor will Investor engage in any hedging or other transaction which
is designed to or could reasonably be expected to lead to or result in a
Disposition of Common Stock of the Company by the Investor or any other person
or entity. Such prohibited hedging or other transactions would include, without
limitation, effecting any short sale or having in effect any short position
(whether or not such sale or position is against the box and regardless of when
such position was entered into) or any purchase, sale or grant of any right
(including without limitation any put or call option) with respect to the Common
Stock of the Company or with respect to any security (other than a broad-based
market basket or index) that includes, relates to or derives any significant
part of its value from the Common Stock of the Company.

         3. REPRESENTATIONS AND WARRANTIES OF THE COMPANY. The Company hereby
represents and warrants to the Investors that as of the date hereof, except as
set forth in this Section, or on the Schedule of Exceptions attached hereto as
Exhibit B (the "Schedule of Exceptions"), with any disclosure thereon being
deemed disclosure for all purposes and all relevant subsections hereof, which
exceptions will be deemed to be representations and warranties as if made
hereunder:

                  (a) ORGANIZATION AND GOOD STANDING. The Company is a
corporation duly organized, validly existing and in good standing under the laws
of the State of Delaware. The Company has all necessary corporate power and
authority to own its assets and to carry on its business as now being conducted
and presently proposed to be conducted. The Company is duly qualified to do
business as a foreign corporation and is in good standing in each jurisdiction
in which its ownership or leasing of assets, or the conduct of its business,
makes such qualification necessary, except where the failure to be so qualified
or in good standing would not have a material adverse effect on the Company and
its subsidiaries considered as a whole.

                  (b) REQUISITE POWER AND AUTHORIZATION. The Company has all
necessary corporate power and authority to execute and deliver this Agreement,
to issue the Shares and to carry out the provisions of this Agreement. All
corporate action on the part of the Company required for the lawful execution
and delivery of this Agreement, and issuance and delivery of the Shares has been
taken. Upon execution and delivery, this Agreement constitutes a valid and
binding obligation of the Company, enforceable in accordance with its terms,
except as enforcement may be limited by insolvency and similar laws affecting
the enforcement of creditors' rights generally and equitable remedies, and
except as the indemnity

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provisions of Section 4 of this Agreement (relating to registration rights) may
be limited by law. The Shares when issued in compliance with the provisions of
this Agreement as the case may be, will be duly authorized and validly issued,
fully paid, non-assessable, and issued in compliance with federal securities
laws and the securities laws of the State of California. No stockholder of the
Company or other person has any preemptive or similar right with respect to the
Shares.

                  (c) SEC DOCUMENTS. The Company has furnished to each Investor
the Company's Annual Report on Form 10-K for the fiscal year ended December 31,
1999, excluding exhibits, and, upon request, all documents that the Company was
required to file, which it represents and warrants it did timely file, with the
SEC under Sections 13 or 14(a) of the Securities Exchange Act of 1934, as
amended (the "Exchange Act"), since December 31, 1998 (collectively, the "SEC
Documents"). As of their respective filing dates, or such later date on which
such reports were amended, the SEC Documents complied in all material respects
with the requirements of the Exchange Act. The SEC Documents as of their
respective dates, or such later date on which such reports were amended, did not
contain any untrue statement of a material fact or omit to state a material fact
required to be stated therein or necessary to make the statements made therein,
in light of the circumstances under which they were made, not misleading. The
financial statements included in the SEC Documents ("Financial Statements")
comply as to form in all material respects with applicable accounting
requirements and with the published rules and regulations of the SEC with
respect thereto. Except as may be indicated in the notes to the Financial
Statements or, in the case of unaudited statements, as permitted by Form 10-Q of
the SEC, the Financial Statements have been prepared in accordance with
generally accepted accounting principles consistently applied and fairly present
the consolidated financial position of the Company and any subsidiaries at the
dates thereof and the consolidated results of their operations and consolidated
cash flows for the periods then ended (subject, in the case of unaudited
statements, to normal, recurring adjustments).

                  (d) CAPITAL STOCK. The authorized capital stock of the Company
consists of 40,000,000 shares of Common Stock, $0.001 par value per share. As of
March 7, 2000, there were 19,552,344 shares of Common Stock issued and
outstanding. All outstanding shares of Common Stock have been duly authorized
and validly issued and are fully paid and non-assessable. As of March 7, 2000,
(a) 6,032,221 shares of Common Stock were reserved for future issuance pursuant
to options granted or which may be granted under the Company's stock option
plans or stock option plans assumed by the Company, (b) 43,555 shares of Common
Stock were reserved for future issuance pursuant to outstanding warrants, and
(c) 294,167 shares of Common Stock were reserved for future issuance pursuant to
a warrant. Except as set forth above, the Company has no outstanding securities
convertible into or exchangeable for Common Stock and no contracts, rights,
options or warrants to purchase or otherwise acquire Common Stock or securities
convertible into or exchangeable for Common Stock. Since March 7, 2000, the
Company has not issued any shares of capital stock or any options, warrants or
other rights with respect thereto except for shares issued upon exercise of
options, warrants and rights, as set forth above.

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                  (e) COMPLIANCE WITH OTHER AGREEMENTS. Neither the execution
and delivery of, nor the consummation of any transaction or execution of any
instrument contemplated by, this Agreement, nor the issuance of the Shares has
constituted or resulted in, or will constitute or result in, a material default
under or breach or violation of any term or provision of the Company's Bylaws,
Certificate of Incorporation, or material contracts with third parties, state or
federal laws, rules or regulations, writs, orders or judgments or decrees which
are applicable to the Company or its properties.

                  (f) INTELLECTUAL PROPERTY. The Company and each of its
subsidiaries owns or is licensed to use all patents, patent applications,
trademarks, trademark applications, trade names, service marks, copyrights,
copyright applications, licenses, permits and know-how (including trade secrets
and other unpatented and/or unpatentable proprietary or confidential
information, systems or procedures) which are material to the conduct of its
business as now being conducted (collectively, "Intangibles"). Neither the
Company nor any of its subsidiaries has received written notice that it is
infringing upon or in conflict with any third party intangibles. Neither the
Company nor any of its subsidiaries has entered into any consent,
indemnification, forbearance to sue or settlement agreements with respect to the
validity of the Company's or such subsidiary's ownership or right to use its
Intangibles. No Intangible is the subject of adversarial proceedings. To its
knowledge, the Company has complied with its contractual obligations relating to
the protection of the Intangibles used pursuant to licenses. To the Company's
knowledge, no person is infringing on or violating any Intangible.

                  (g) CONSENTS. All consents necessary for the Company to
perform its respective obligations hereunder have been obtained, except for the
approval of the SEC of the registration statement contemplated by Section 4.

                  (h) NO MATERIAL ADVERSE CHANGE. Since December 31, 1999,
except as set forth in the Offering Memorandum delivered to each Investor, there
has not been:

                         (i) any changes in the assets, liabilities, financial
condition or operations of the Company from that reflected in the Financial
Statements except changes in the ordinary course of business which have not
been, either in any individual case or in the aggregate, materially adverse to
the Company and its subsidiaries taken as a whole;

                         (ii) any material change, except in the ordinary course
of business, in the contingent obligations of the Company whether by way of
guarantee, endorsement, indemnity, warranty or otherwise;

                         (iii) any damage, destruction or loss, whether or not
covered by insurance, materially and adversely affecting the properties or
business of the Company; or

                         (iv) any declaration or payment of any dividend or
other distribution of the assets of the Company.

                  (i) INSURANCE. The Company and its subsidiaries maintain such
insurance relating to their business, operations, assets as is appropriate to
their business, assets and

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operations, in such amounts and against such risks as are customarily carried
and insured against by owners of comparable businesses, assets and operations,
and such insurance coverages will be continued in full force and effect to and
including the Closing Date other than those insurance coverages in respect of
which the failure to continue in full force and effect could not reasonably be
expected to have a Material Adverse Effect.

                  (j) LITIGATION. There is no action, suit, proceeding or
investigation pending or, to the Company's knowledge, currently threatened
against the Company that questions the validity of this Agreement, or the right
of the Company to enter into such agreements, or to consummate the transactions
contemplated hereby, or that might result, either individually or in the
aggregate, in any material adverse changes in the business, assets, condition,
affairs or prospects of the Company, financially or otherwise, or any change in
the current equity ownership of the Company.

         4.       REGISTRATION RIGHTS.

                  (a) DEFINITIONS. For purposes of this Section 4:

                         (i) "Register", "registered", and "registration" refer
to a registration effected by preparing and filing a registration statement in
compliance with the Securities Act, and the declaration or ordering of
effectiveness of such registration statement.

                         (ii) "Registrable Securities" means all shares of
Common Stock of the Company issued or issuable under this Agreement, excluding
in all cases, however, all Registrable Securities sold pursuant to Rule 144.

                         (iii) "Holder" means any person owning of record
Registrable Securities that have not been sold to the public or any assignee of
record of such Registrable Securities to whom rights under this Section 4
(and/or, with respect to the rights of the Investors set forth in Section 5,
under such Section 5) have been assigned in accordance with this Agreement.

                  (b) SHELF REGISTRATION.

                         (i) The Company will file as soon as practicable, and
in no event later than 30 days after the final Closing, a registration statement
with the SEC under the Securities Act for the sale and distribution of all of
the Holders' Registrable Securities and thereafter shall use its best efforts to
secure the effectiveness of such registration statement as soon as practicable
thereafter.

                         (ii) The Company will pay all expenses incurred in
connection with any registration, qualification and compliance requested
hereunder (excluding underwriters' or brokers' discounts and commissions and the
fees and disbursements of counsel for any Investor), including without
limitation all filing, registration and qualification, printers' and accounting
fees and the fees and disbursements of counsel for the Company.

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                         (iii) The Company will use its best efforts to cause
the registration statement to remain effective until the earliest of (A) the
date ending two years after the final Closing, (B) the date on which all the
Registrable Securities have been resold, or (C) the date on which each Holder of
Registrable Securities is able to sell all of such Holder's Registrable
Securities in a single three (3) month period without registration under the
Securities Act pursuant to Rule 144.

                  (c) OBLIGATIONS OF THE COMPANY. In order to effect the
registration of any Registrable Securities under Section 4(b) of this Agreement,
the Company will, as expeditiously as reasonably possible:

                         (i) Prepare and file with the SEC a registration
statement with respect to such Registrable Securities and use its best efforts
to cause such registration statement to become effective, and deliver such
registration statement, at the time of such filing, to each Holder.

                         (ii) Prepare and file with the SEC such amendments and
supplements to such registration statement and the prospectus used in connection
with such registration statement as may be necessary to comply with the
provisions of the Securities Act with respect to the disposition of all
securities covered by such registration statement.

                         (iii) Furnish to the Holders such number of copies of a
prospectus in conformity with the requirements of the Securities Act, and such
other documents as they may reasonably request in order to facilitate the
disposition of the Registrable Securities owned by them that are included in
such registration.

                         (iv) Use its best efforts to register and qualify the
securities covered by such registration statement under such other securities or
"blue sky" laws of such jurisdictions as will be reasonably requested by the
Holders, provided that the Company will not be required in connection therewith
or as a condition thereto to qualify to do business or to file a general consent
to service of process in any such states or jurisdictions.

                         (v) Notify each Holder of Registrable Securities
covered by such registration statement at any time when a prospectus relating
thereto is required to be delivered under the Securities Act of the happening of
any event as a result of which the prospectus included in such registration
statement, as then in effect, includes an untrue statement of a material fact or
omits to state a material fact required to be stated therein or necessary to
make the statements therein not misleading in the light of the circumstances
then existing, and upon such notice the Company shall use its best efforts to
promptly correct such misstatement or omission and deliver to each Holder copies
of such corrected prospectus. The Company shall have the right, upon such
notice, to suspend the delivery of prospectuses included in such registration
statement from the date of notice until the date of such correction. The period
during which the Company is required to keep any registration statement filed
pursuant to Section 4(b) effective shall be extended for the amount of time
required to amend such registration statement and deliver such prospectus
relating thereto.

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                  (d) FURNISH INFORMATION. It will be a condition precedent to
the obligations of the Company to take any action pursuant to Section 4(b)
hereof that the selling Holders will furnish to the Company such information
regarding themselves, the Registrable Securities held by them, and the intended
method of disposition of such securities as will be required to effect the
registration of their Registrable Securities.

                  (e) INDEMNIFICATION. In the event any Registrable Securities
are included in a registration statement under Section 4(b) hereof:

                         (i) To the extent permitted by law, the Company will
indemnify and hold harmless each Holder, the partners, stockholders, officers
and directors of each Holder, any underwriter (as defined in the Securities Act)
for such Holder and each person, if any, who controls such Holder or underwriter
within the meaning of the Securities Act or the Exchange Act against any losses,
claims, damages, or liabilities to which they may become jointly or severally
liable subject under the Securities Act, the Exchange Act or other federal or
state securities law, insofar as such losses, claims, damages, or liabilities
(or actions in respect thereof) arise out of or are based upon any of the
following statements, omissions or violations (collectively, a "Violation"):

                              (A) any untrue statement or alleged untrue
statement of a material fact contained in such registration statement, including
any preliminary prospectus or final prospectus contained therein or any
amendments or supplements thereto;

                              (B) the omission or alleged omission to state
therein a material fact required to be stated therein, or necessary to make the
statements therein not misleading; or

                              (C) any violation or alleged violation by the
Company of the Securities Act, the Exchange Act, any federal or state securities
law or any rule or regulation promulgated under the Securities Act, the Exchange
Act or any federal or state securities law in connection with the offering
covered by such registration statement;

and the Company will reimburse each such Holder, partner, stockholder, officer
or director, underwriter or controlling person for any legal or other expenses
reasonably incurred by them, as incurred, in connection with investigating or
defending any such loss, claim, damage, liability or action; provided however,
that the indemnity agreement contained in this Section 4(e)(i) will not apply to
amounts paid in settlement of any such loss, claim, damage, liability or action
if such settlement is effected without the consent of the Company (which consent
will not be unreasonably withheld), nor will the Company be liable in any such
case for any such loss, claim, damage, liability or action to the extent that it
arises out of or is based upon a Violation which occurs in reliance upon and in
conformity with written information furnished expressly for use in connection
with such registration by such Holder, partner, stockholder, officer, director,
underwriter or controlling person of such Holder.

                         (ii) To the extent permitted by law, each selling
Holder will indemnify and hold harmless the Company, each of its directors, each
of its officers who have

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signed the registration statement, each person, if any, who controls the Company
within the meaning of the Securities Act, any underwriter and any other Holder
selling securities under such registration statement or any of such other
Holder's partners, directors or officers or stockholders or any person who
controls such Holder within the meaning of the Securities Act or the Exchange
Act, against any losses, claims, damages or liabilities (joint or several) to
which the Company or any such director, officer, controlling person, underwriter
or other such Holder, partner or director, officer, stockholder or controlling
person of such other Holder may become subject under the Securities Act, the
Exchange Act or other federal or state law, insofar as such losses, claims,
damages or liabilities (or actions in respect thereto) arise out of or are based
upon any Violation that arises solely as a result of written information
furnished by such Holder expressly for use in connection with such registration;
and each such Holder will reimburse any legal or other expenses reasonably
incurred by the Company or any such director, officer, controlling person,
underwriter or other Holder, partner, officer, director, stockholder or
controlling person of such other Holder in connection with investigating or
defending any such loss, claim, damage, liability or action; provided, however,
that the indemnity agreement contained in this Section 4(e)(ii) will not apply
to amounts paid in settlement of any such loss, claim, damage, liability or
action if such settlement is effected without the consent of the Holder, which
consent will not be unreasonably withheld; and provided further, that the total
amounts payable in indemnity by a Holder under this Section 4(e)(ii) in respect
of any Violation will not exceed the aggregate proceeds (net of discounts)
received by such Holder upon the sale of the Shares.

                         (iii) Promptly after receipt by an indemnified party
under this Section 4(e) of notice of the commencement of any action (including
any governmental action), such indemnified party will, if a claim in respect
thereof is to be made against any indemnifying party under this Section 4(e),
deliver to the indemnifying party a written notice of the commencement thereof
and the indemnifying party will have the right to participate in, and, to the
extent the indemnifying party so desires, jointly with any other indemnifying
party similarly noticed, to assume the defense thereof with counsel mutually
satisfactory to the parties; provided, however, that an indemnified party will
have the right to retain its own counsel, with the fees and expenses to be paid
by the indemnifying party, if representation of such indemnified party by the
counsel retained by the indemnifying party would be inappropriate due to actual
differing interests between such indemnified party and any other party
represented by such counsel in such proceeding. The failure to deliver written
notice to the indemnifying party within a reasonable time of the commencement of
any such action, if the indemnifying party is materially prejudiced thereby,
will relieve such indemnifying party of liability, but only to the extent that
such indemnifying party is prejudiced with respect to a specific claim.

                         (iv) The foregoing indemnity agreement with respect to
any prospectus shall not inure to the benefit of any Holder or underwriter, or
any person controlling such Holder or underwriter, from whom the person
asserting any losses, claims, damages or liabilities purchased Registrable
Securities, if a copy of the prospectus (as then amended or supplemented if the
Company shall have furnished any amendments or supplements thereto) provided by
the Company was not sent or given by or on behalf of such Holder or underwriter
to such person, if required by law so to have been delivered, at or prior

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to the written confirmation of the sale of the Registrable Securities to such
person, and if the prospectus (as so amended or supplemented) would have cured
the defect giving rise to such loss, claim, damage or liability.

                         (v) If the indemnification provided for in Sections
4(e)(i) or 4(e)(ii) hereof shall be unavailable to hold harmless an indemnified
party in respect of any liability under the Securities Act, then, and in each
such case, the indemnifying party, in lieu of indemnifying such indemnified
party hereunder, shall contribute to the amount paid or payable by such
indemnified party as a result of such loss, liability, claim, damage or expense
in such proportion as is appropriate to reflect the relative fault of the
indemnifying party on the one hand and of the indemnified party on the other in
connection with the statement or omissions that resulted in such loss,
liability, claim, damage or expense as well as any other relevant equitable
considerations. The relative fault of the indemnifying party and of the
indemnified party shall be determined by reference to, among other things,
whether the untrue or alleged untrue statement of a material fact or the
omission to state a material fact relates to information supplied by the
indemnifying party or by the indemnified party and the parties' relative intent,
knowledge, access to information and opportunity to correct or prevent such
statement or omission; provided that in no event shall any contribution under
this subsection (v) by any Holder exceed the gross proceeds from the offering
received by such indemnifying party. No person or entity guilty of fraudulent
misrepresentation (within the meaning of Section 11(f) of the Securities Act)
will be entitled to contribution from any person or entity who was not guilty of
such fraudulent misrepresentation.

                         (vi) The obligations of the Company and Holders under
this Section 4(e) will survive the completion of any offering of Registrable
Securities in a registration statement, and otherwise.

                  (f) RULE 144 REPORTING. With a view to making available the
benefits of certain rules and regulations of the Commission which may at any
time permit the sale of the Registrable Securities to the public without
registration, while a public market exists for the Common Stock of the Company,
the Company will:

                         (i) Make and keep public information available, as
those terms are understood and defined in Rule 144 under the Securities Act, at
all times while the Company is reporting under the Exchange Act;

                         (ii) Use its best efforts to file with the SEC in a
timely manner all reports and other documents required of the Company under the
Securities Act and the Exchange Act (at any time it is subject to such reporting
requirements); and

                         (iii) So long as a Holder owns any Registrable
Securities, furnish to the Holder forthwith upon request a written statement by
the Company as to its compliance with the reporting requirements of Rule 144,
and of the Securities Act and the Exchange Act (at any time it is subject to the
reporting requirements of the Exchange Act), a copy of the most recent annual or
quarterly report of the Company, and such other reports and documents of the
Company as a Holder may reasonably request in availing itself of any rule or
regulation

                                      -11-

<PAGE>

of the SEC allowing a Holder to sell any such securities without registration
(at any time the Company is subject to the reporting requirements of the
Exchange Act).

                  (g) If any Investor shall propose to sell any Registrable
Securities pursuant to the registration statement, such Investor shall notify
the Company of its intent to do so at least three (3) full business days prior
to such sale. Such notice shall be deemed to constitute a representation that
any written information previously supplied by such Investor is accurate as of
the date of such notice. At any time within such three (3) business-day period,
the Company may notify the Investor that the Company will refuse to permit the
Investor to resell any Registrable Securities pursuant to the registration
statement for an initial period not to exceed thirty (30) days; PROVIDED,
HOWEVER, that in order to exercise this right, the Company must deliver a
certificate in writing to the Investor to the effect that a delay in such sale
is necessary because a sale pursuant to such registration statement in its
then-current form would not be in the best interests of the Company and its
stockholders due to disclosure obligations of the Company. In such event, the
Company shall use its best efforts to amend the registration statement, if
necessary, and to take all other actions reasonably necessary to allow such
sale, and shall notify the Investor promptly after it has determined that such
sale has become permissible. Notwithstanding the foregoing, the Company shall
not be entitled to exercise its right to refuse to permit a sale by any
particular Investor more than three (3) times in any calendar year or for more
than two (2) consecutive thirty (30) day periods in any calendar year; PROVIDED,
HOWEVER, that no particular Investor will be refused permission to sell under
this Section 4(g) at the same time that another Investor is permitted to sell
under the registration statement. Each Investor hereby covenants and agrees that
it will not sell any Registrable Securities pursuant to the registration
statement during the periods the registration statement is withdrawn as set
forth in this Section 4(g).

                  (h) INVESTOR INFORMATION. Each Investor covenants that it will
promptly notify the Company of any changes in the information set forth in the
registration statement regarding such Investor or such Investor's "Plan of
Distribution."

         5. CONDITIONS TO OBLIGATIONS OF THE INVESTORS. The obligation of each
Investor to purchase the Shares at the Closing is subject to the fulfillment on
or prior to such Closing of the following conditions, any of which may be waived
by such Investor:

                  (a) REPRESENTATIONS AND WARRANTIES CORRECT; PERFORMANCE OF
OBLIGATIONS. The representations and warranties made by the Company in Section 3
hereof shall be true and correct when made, and shall be true and correct at the
time of the Closing with the same force and effect as if they had been made on
and as of said date, except for representations and warranties made as of a
specific date which shall be true and correct as of such date; and the Company
shall have performed all obligations and conditions herein required to be
performed or observed by it under this Agreement on or prior to the Closing.

                  (b) CONSENTS AND WAIVERS. The Company shall have obtained any
and all consents (including all governmental or regulatory consents, approvals
or authorizations required in connection with the valid execution and delivery
of this Agreement), permits and

                                      -12-

<PAGE>

waivers necessary or appropriate for consummation of the transactions
contemplated by this Agreement.

                  (c) COMPLIANCE CERTIFICATE. The Company shall have delivered
to the Investors a certificate, executed by the Chief Financial Officer of the
Company, dated the day of the Closing, certifying to the fulfillment of the
conditions specified in subsection (a) of this Section 5.

                  (d) OPINION OF COMPANY'S COUNSEL. Investors shall have
received from Pillsbury Madison & Sutro LLP, counsel to the Company, an opinion
addressed to the Investors, dated the day of the Closing and in substantially
the form attached hereto as Exhibit C.

                  (e) MINIMUM PURCHASE. The Company shall have received executed
Agreements to purchase Shares with an aggregate purchase price of not less than
$7,500,000 and full payment of the purchase price for all of the Shares to be
sold at the Closing.

         6. CONDITIONS TO OBLIGATIONS OF THE COMPANY. The obligation of the
Company to sell and issue the Shares to each Investor at each Closing is subject
to the fulfillment on or prior to the Closing of the following conditions, any
of which may be waived by the Company:

                  (a) REPRESENTATIONS AND WARRANTIES. The representations and
warranties made by such Investor in Section 2 hereof shall be true and correct
when made, and shall be true and correct at the time of the Closing with the
same force and effect as if they had been made on and as of said date.

                  (b) CONSENTS AND WAIVERS. The condition set forth in
subsection (b) of Section 5 hereof shall have been fulfilled.

                  (c) MINIMUM PURCHASE. The Company shall have received executed
subscription Agreements to purchase Shares with an aggregate purchase price of
not less than $7,500,000 and full payment of the purchase price for all of the
Shares to be sold at the Closing.

         7. MISCELLANEOUS.

                  (a) GOVERNING LAW. This Agreement will be governed by and
construed in accordance with the internal laws of the State of California
applicable to contracts made among residents of, and wholly to be performed
within, the State of California, without regard to principles of conflict of
laws or choice of laws.

                  (b) FURTHER INSTRUMENTS. From time to time, each party hereto
will execute and deliver such instruments and documents as may be reasonably
necessary to carry out the purposes and intent of this Agreement.

                                      -13-

<PAGE>

                  (c) SUCCESSORS; NO OTHER BENEFICIARIES. This Agreement will be
binding upon and will inure to the benefit of the executors, administrators,
legal representatives, heirs, successors, and assigns of the parties hereto;
PROVIDED, HOWEVER, that (i) rights of Investors hereunder may be transferred
only in connection with (and to the transferee of) Common Stock of the Company
purchased by a Investor hereunder, but the Company may prohibit such transfer of
rights if the transfer to a particular transferee would not, in the good faith
judgment of the Company's Board of Directors, be in the Company's best
interests, and (ii) any transferee of any shares of stock of the Company
affected by this Agreement to whom rights are so transferred (a "PERMITTED
TRANSFEREE") will be required, as a condition precedent to acquiring such
shares, to agree in writing to be bound by all the terms and conditions of this
Agreement applicable to such Permitted Transferee's transferor, and (iii) upon
and after such transfer the Permitted Transferee will be deemed to be an
Investor for purposes of this Agreement. Nothing in this Agreement, express or
implied, is intended to confer upon any party other than the parties hereto or
their respective successors and assigns any rights, remedies, obligations, or
liabilities under or by reason of this Agreement, except as expressly provided
in this Agreement.

                  (d) COUNTERPARTS. This Agreement may be executed in two or
more counterparts, each of which will be deemed an original, but all of which
together will constitute one and the same instrument. This Agreement will be
effective following the parties signatory hereto upon such counterpart signature
by all initial parties hereto.

                  (e) ENTIRE AGREEMENT. This Agreement, including and
incorporating the Schedule of Exceptions and all Exhibits attached hereto and
referred to herein, constitutes and contains the entire agreement and
understanding of the parties regarding the subject matter of this Agreement and
supersedes in its entirety any and all prior negotiations, correspondence,
understandings and agreements among the parties respecting the subject matter
hereof.

                  (f) NOTICES. Any notice required to be given or delivered to
the Company under the terms of this Agreement shall be addressed to the
Secretary of the Company at its principal corporate offices. Any notice required
to be given or delivered to an Investor shall be addressed to the Investor at
the address indicated below or to such other address as such party may designate
in writing from time to time to the Company. Unless otherwise provided, notice
required or permitted to be given to a party pursuant to the provisions of this
Agreement will be in writing and will be effective and deemed given under this
Agreement on the earliest of (i) the date of personal delivery, or (ii) the date
of delivery by facsimile, or (iii) the business day after deposit with a
nationally recognized courier or overnight service, including Federal Express or
Express Mail, for United States deliveries or three (3) business days after such
deposit for deliveries outside of the United States, or (iv) three (3) business
days after deposit in the United States mail by registered or certified mail for
United States deliveries. All notices not delivered personally or by facsimile
will be sent with postage and other charges prepaid and properly addressed to
the party to be notified at the address set forth on the signature page, or at
such other address as such party may designate by ten (10) days' advance written
notice to the other parties hereto. All notices for delivery outside the United
States will be sent by facsimile, or by nationally recognized courier or
overnight service, including Express Mail. Any notice given hereunder to more
than one person will be deemed

                                      -14-

<PAGE>

to have been given, for purposes of counting time periods hereunder, on the date
given to the last party required to be given such notice.

                  (g) BROKER'S FEE. Each Investor acknowledges that the Company
intends to pay a fee and issue warrants to the Placement Agent, in respect of
the sale of the Shares to the Investors. Each of the parties hereto hereby
represents that, on the basis of any actions and agreements by it, and except
for any finders' fees to be paid out of the Placement Agent's fee, there are no
other brokers or finders entitled to compensation in connection with the sale of
the Shares to the Investors.

                  (h) AMENDMENTS AND WAIVERS. Any term of this Agreement may be
amended and the observance of any term of the Agreement may be waived (either
generally or in a particular instance and either retroactively or
prospectively), only with the written consent of the Company and by Investors
holding at least fifty percent (50%) of the Registrable Securities. Any
amendment or waiver effected in accordance with this Section 7(h) will be
binding upon the Company, each Investor, and their permitted transferees and
assignees.

                  (i) SEVERABILITY. If one or more provisions of this Agreement
are held to be unenforceable under applicable law, such provisions will be
excluded from this Agreement to the extent unenforceable and the balance of such
provisions, and of this Agreement, will be interpreted as if such provision or
part and hereof were so excluded and will be enforceable in accordance with its
terms.

                  (j) AGGREGATION OF STOCK. All shares of Common Stock held or
acquired by affiliated entities or persons will be aggregated together for the
purpose of determining the availability of any rights under this Agreement.

                  (k) EXPENSES. The Company and each Investor will bear its own
costs and expenses incurred on its behalf with respect to the Agreement and the
transactions contemplated hereby, including fees of legal counsel.

                                      -15-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                                  TO BE COMPLETED BY INVESTOR

T. Rowe Price New Horizons Fund, Inc.     Shares Subscribed:     1,333,334
-------------------------------------                            ---------------
(Print Name of Individual or Entity)                             (Print Name of
                                                                 Individual or
                                                                 Entity)

By:       /s/ Charles G. Pepin
          ---------------------------
         (Signature)

Name:       Charles G. Pepin
          ---------------------------

Title:     V.P.
          ---------------------------
Address: 100 East Pratt Street
         ----------------------------
         Baltimore, Maryland 21202
-------------------------------------

-------------------------------------

-------------------------------------

Tax ID:
        -----------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:        /s/ Gerard A. Wills
         -----------------------------------
         (Signature)

Name:      Gerard A. Wills
         -----------------------------------

Title:     Vice President - Finance
         -----------------------------------

Address: Trega Biosciences, Inc.
         9880 Campus Point Drive
         San Diego, CA
         Attention:  General Counsel

                                      -16-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                                        TO BE COMPLETED BY INVESTOR

Green Line Mutual Funds - Green Line      Shares Subscribed:   226,000
------------------------------------                           -----------------
Heath Sciences Fund                                            (Print Name of
-------------------                                            Individual or
                                                               Entity)
BY: T. ROWE PRICE ASSOCIATES, ADVISOR,
--------------------------------------
INC.
--------------------------------------
(Print Name of Individual or Entity)

By:       /s/ Charles G. Pepin
         -----------------------------
         (Signature)

Name:      Charles G. Pepin
         -----------------------------

Title:     Vice President
         -----------------------------

Address: 100 East Pratt Street
         -----------------------------
         Baltimore, Maryland 21202
--------------------------------------

--------------------------------------

--------------------------------------

Tax ID:
        ------------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:        /s/ Gerard A. Wills
        ------------------------------
         (Signature)

Name:      Gerard A. Wills
        ------------------------------

Title:    Vice President - Finance
        ------------------------------

Address:       Trega Biosciences, Inc.
               9880 Campus Point Drive
               San Diego, CA
               Attention: General Counsel

                                      -17-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                                   TO BE COMPLETED BY INVESTOR

T. Rowe Price Health Sciences Fund, Inc.   Shares Subscribed:   440,666
----------------------------------------                        ----------------
(Print Name of Individual or Entity)                            (Print Name of
                                                                Individual or
                                                                Entity)

By:      /s/ Charles G. Pepin
         -------------------------
         (Signature)

Name:      Charles G. Pepin
         -------------------------

Title:     V.P.
         -------------------------
Address: 100 East Pratt Street
         -------------------------
         Baltimore, Maryland 21202
----------------------------------

----------------------------------

----------------------------------

Tax ID:
         -------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:      /s/ Gerard A. Wills
         -------------------------
         (Signature)

Name:      Gerard A. Wills
         -------------------------

Title:     Vice President - Finance
         -------------------------

Address:       Trega Biosciences, Inc.
               9880 Campus Point Drive
               San Diego, CA
               Attention:  General Counsel

                                      -18-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                               TO BE COMPLETED BY INVESTOR

EGM Technology Fund LP                 Shares Subscribed:  109,667
------------------------------------                       -------------------
(Print Name of Individual or Entity)                       (Print Name of
                                                           Individual or Entity)

By:        /s/ Marc Pentopoulos
           -------------------------
         (Signature)

Name:      Marc Pentopoulos
           -------------------------

Title:     Portfolio Manager
           -------------------------

Address:  1 Embarcadero Center
        ----------------------------

          Suite 2140
        ----------------------------
          SF, CA 94111
        ----------------------------

        ----------------------------

Tax Id:   94-334-3744
        ----------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:        /s/ Gerard A. Wills
        ----------------------------
         (Signature)

Name:      Gerard A. Wills
        ----------------------------

Title:     CFO
        ----------------------------

Address:       Trega Biosciences, Inc.
               9880 Campus Point Drive
               San Diego, CA
               Attention:  General Counsel

                                      -19-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                               TO BE COMPLETED BY INVESTOR

EGM Medical Technology Offshore Fund   Shares Subscribed:     72,000
------------------------------------                      ---------------------
(Print Name of Individual or Entity)                      (Print Name of
                                                          Individual or Entity)

By:        /s/ Marc Pentopoulos
         ---------------------------
         (Signature)

Name:      Marc Pentopoulos
         ---------------------------

Title:     Portfolio Manager
         ---------------------------

Address:  1 Embarcadero
         ---------------------------
         Suite 2140
------------------------------------
         SF, CA 94111
------------------------------------

------------------------------------

Tax ID:
        ----------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:        /s/ Gerard A. Wills
         ---------------------------
         (Signature)

Name:      Gerard A. Wills
         ---------------------------

Title:     CFO
         ---------------------------

Address: Trega Biosciences, Inc.
         9880 Campus Point Drive
         San Diego, CA
         Attention:  General Counsel

                                      -20-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                                       TO BE COMPLETED BY INVESTOR

Special Situations Private Equity Fund, L.P.   Shares            300,000
--------------------------------------------   Subscribed:      ----------------
(Print Name of Individual or Entity)                            (Print Name of
                                                                Individual or
                                                                Entity)

By:        /s/ David Greenhouse
         ------------------------------
         (Signature)

Name:      David Greenhouse
         ------------------------------

Title:     M.D.
         ------------------------------

Address:  153 East 53Rd Street
         ------------------------------
         New York, NY 10022

         ------------------------------

         ------------------------------

Tax ID:  13-3916551
         ------------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:        /s/ Gerard A. Wills
         ------------------------------
         (Signature)

Name:      Gerard A. Wills
         ------------------------------

Title:      CFO
         ------------------------------

Address:       Trega Biosciences, Inc
               9880 Campus Point Drive
               San Diego, CA
               Attention:  General Counsel

                                      -21-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                                             TO BE COMPLETED BY INVESTOR

Pequot Scout Fund L.P.                 Shares Subscribed:       300,000
------------------------------------                          ------------------
(Print Name of Individual or Entity)                           (Print Name of
                                                               Individual or
                                                               Entity)
By:        /s/ David J. Malat
         ---------------------------
         (Signature)

Name:    David J. Malat
         ---------------------------

Title:     Chief Financial Officer
         ---------------------------

Address:   C/o David J. Malat
         ---------------------------
Pequot Capital Management, Inc.
------------------------------------
500 Nyla Farms Road
------------------------------------
Westport, CT 06880
------------------------------------
Tax ID:   13-3741801
        ----------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:        /s/ Gerard A. Wills
       -----------------------------
         (Signature)

Name:      Gerard A. Wills
       -----------------------------

Title:     CFO
       -----------------------------

Address:       Trega Biosciences, Inc.
               9880 Campus Point Dr
               San Diego, CA
               Attention:  General Counsel

                                      -22-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                                TO BE COMPLETED BY INVESTOR

Jackson Square Partners, L.P.           Shares Subscribed:    181,667
------------------------------------                         -------------------
(Print Name of Individual or Entity)                          (Print Name of
                                                              Individual or
                                                              Entity)

By:        Michael D. Baldridge
         -----------------------------
         (Signature)

Name:      Michael D. Baldridge
         -----------------------------

Title:     Member Manager
         -----------------------------

Address:  Jackson Square Partners, L.P.
         -----------------------------
909 Montgomery Street, Suite 600
--------------------------------------
San Francisco, CA 94133
--------------------------------------

--------------------------------------

Tax ID:   94-3307834
       -------------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:        /s/ Gerard A. Wills
       -------------------------------
         (Signature)

Name:      Gerard A. Wills
       -------------------------------

Title:     CFO
       -------------------------------

Address:       Trega Biosciences, Inc.
               9880 Campus Point Drive
               San Diego, CA
               Attention:  General Counsel

                                      -23-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                                   TO BE COMPLETED BY INVESTOR

         Baystar International, LTD        Shares Subscribed:     200,000
-------------------------------------                            ---------------
(Print Name of Individual or Entity)                             (Print Name of
                                                                 Individual or
                                                                 Entity)
By:        /s/ Brian Davidson
         ----------------------------
         (Signature)

Name:      Brian Davidson
         ----------------------------
Title:     Director
         ----------------------------
Address: 1500 W. Market Street
         ----------------------------
         Suite 200
-------------------------------------
         Mequon, WI 53092
-------------------------------------

Tax ID:   NONE
         ----------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:        /s/ Gerard A. Wills
       ------------------------------
         (Signature)

Name:      Gerard A. Wills
       ------------------------------

Title:      CFO
       ------------------------------

Address:       Trega Biosciences, Inc.
               9880 Campus Point Drive
               San Diego, CA
               Attention:  General Counsel

                                      -24-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                                 TO BE COMPLETED BY INVESTOR

         Baystar Capital. LP             Shares Subscribed:      300,000
------------------------------------                            ----------------
(Print Name of Individual or Entity)                            (Print Name of
                                                                Individual or
                                                                Entity)

By:        /s/ Brian Davidson
         ---------------------------
         (Signature)

Name:      Brian Davidson
         ---------------------------

Title:     Director
         ---------------------------

Address:   1500 W. Market Street
         ---------------------------
         Suite 200
------------------------------------
         Mequon, WI 53092
------------------------------------

------------------------------------

Tax ID:   39-1956054
        ----------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:        /s/ Gerard A. Wills
       -----------------------------
         (Signature)

Name:      Gerard A. Wills
       -----------------------------

Title:     CFO
       -----------------------------

Address:       Trega Biosciences, Inc.
               9880 Campus Point Drive
               San Diego, CA
               Attention:  General Counsel

                                      -25-
<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                                 TO BE COMPLETED BY INVESTOR

         NARRAGANSETT I, LP              Shares Subscribed:      30,934
------------------------------------                            ----------------
(Print Name of Individual or Entity)                            (Print Name of
                                                                Individual or
                                                                Entity)

By:        /s/ Joseph L. Dowling III
         ---------------------------
         (Signature)

Name:      Joseph L. Dowling III
         ---------------------------

Title:     Managing Member
         ---------------------------

Address:   374 Park Avenue
         ---------------------------
         14Th Floor
------------------------------------
         New York, NY 10152
------------------------------------

------------------------------------

Tax ID:   13-4032957
        ----------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:         /s/ Gerard A. Wills
       -----------------------------
         (Signature)

Name:       Gerard A. Wills
       -----------------------------

Title:     CFO
       -----------------------------

Address:       Trega Biosciences, Inc.
               9880 Campus Point Drive
               San Diego, CA
               Attention:  General Counsel

                                      -26-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                                 TO BE COMPLETED BY INVESTOR

         Paul M. Ginsburg                Shares Subscribed:      33,333
------------------------------------                            ----------------
(Print Name of Individual or Entity)                            (Print Name of
                                                                Individual or
                                                                Entity)
By:        /s/ Paul M. Ginsburg
         ---------------------------
         (Signature)

Name:      Paul M. Ginsburg
         ---------------------------

Title:
         ---------------------------

Address: P.O. Box 1774
         ---------------------------
         Ross, CA 94957-1774
------------------------------------
For Delivery Via Courier:
------------------------------------
         50 Shady Lane
------------------------------------
         Ross, CA 94957
------------------------------------

Tax ID:   ###-##-####
        ----------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:        /s/ Gerard A. Wills
       -----------------------------
         (Signature)
       -----------------------------

Name:      Gerard A. Wills
       -----------------------------
Title:     CFO
       -----------------------------

Address:       Trega Biosciences,
               9880 Campus Point
               San Diego, CA
               Attention:  General Counsel

                                      -27-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                                   TO BE COMPLETED BY INVESTOR

The Timken Living Trust U/A/D/ 9/14/99     Shares Subscribed:      83,334
--------------------------------------                            --------------
(Print Name of Individual or Entity)                              (Print Name of
                                                                  Individual or
                                                                  Entity)
By:      /s/ William R. Timken, Trustee
         ------------------------------
         (Signature)

Name:      William R. Timken
         ------------------------------

Title:     Trustee
         ------------------------------

Address: Attn.: Diane L. Larson
         ------------------------------
         7 Mercury Avenue
---------------------------------------
         Tiburon, CA 94920
---------------------------------------
         (415) 799-1184
---------------------------------------

Tax ID:   ###-##-####
        -------------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:        /s/ Gerard A. Wills
       --------------------------------
         (Signature)

Name:      Gerard A. Wills
       --------------------------------

Title:     CFO
       --------------------------------

Address:       Trega Biosciences, Inc.
               9880 Campus Point Drive
               San Diego, CA
               Attention:  General Counsel

                                      -28-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                                  TO BE COMPLETED BY INVESTOR

         Narragansett Offshore Ltd        Shares Subscribed:      22,400
-------------------------------------                            ---------------
(Print Name of Individual or Entity)                             (Print Name of
                                                                 Individual or
                                                                 Entity)
By:        /s/ Joseph L. Dowling, III
         ----------------------------
         (Signature)

Name:      Joseph L. Dowling III
         ----------------------------

Title:     Managing Member
         ----------------------------

Address: 375 Park Avenue
         ----------------------------
         14Th Floor
-------------------------------------
         New York, NY 10152
-------------------------------------

Tax ID:     N/A
         ----------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:        /s/ Gerard A. Wills
         ----------------------------
         (Signature)

Name:      Gerard A. Wills
         ----------------------------
Title:       CFO
         ----------------------------

Address:       Trega Biosciences, Inc.
               9880 Campus Point Drive
               San Diego, CA
               Attention:  General Counsel

                                      -29-

<PAGE>

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date and year first above written.

INVESTOR                                 TO BE COMPLETED BY INVESTOR

         Cypress VI Partners             Shares Subscribed:      33,333
------------------------------------                            ----------------
(Print Name of Individual or Entity)                            (Print Name of
                                                                Individual or
                                                                Entity)
By:        /s/ Leonard S. Eber
       -----------------------------
         (Signature)

Name:      Leonard S. Eber
       -----------------------------

Title:    Managing Partner/ Cypress Partners
       -------------------------------------
Address: 126 Cypress
         ---------------------------
         Kentfield, CA 94904
------------------------------------

------------------------------------

------------------------------------

Tax ID:   914-3195326
        ----------------------------

COMPANY

TREGA BIOSCIENCES, INC.

By:        /s/ Gerard A. Wills
       -----------------------------
         (Signature)

Name:       Gerard A. Wills
       -----------------------------

Title:     CFO
       -----------------------------

Address:       Trega Biosciences, Inc.
               9880 Campus Point Drive
               San Diego, CA
               Attention:  General Counsel

                                      -30-

<PAGE>

                                    EXHIBIT A

                              SCHEDULE OF INVESTORS
                             TREGA BIOSCIENCES, INC.
                             SUBSCRIPTION AGREEMENT
                                  APRIL 4, 2000

<TABLE>
<CAPTION>
                                             Number               Purchase
Purchaser                                   of Shares              Price
---------                                   ---------              -----

<S>                                          <C>                <C>
T. Rowe Price
New Horizons Fund, Inc.                      1,333,334          $4,000,002

Green Line Mutual Funds -
Green Line Health Sciences Fund                226,000             678,000

T. Rowe Price
Health Sciences Fund, Inc.                     440,666           1,321,998

EGM Medical Technology
Fund LP                                        109,667             329,001

EGM Medical Technology
Offshore Fund                                   72,000             216,000

Special Situations Private
Equity Fund, L.P.                              300,000             900,000

Pequot Scout Fund, L.P.                        300,000             900,000

Jackson Square Partners, L.P.                  181,667             545,001

Bay Star International, LTD                    200,000             600,000

Bay Star Capital, L.P.                         300,000             900,000

Narragansett I, LP                              30,934              92,802

Paul M. Ginsburg                                33,333              99,999
</TABLE>

<PAGE>

<TABLE>
<CAPTION>

                                             Number               Purchase
Purchaser                                   of Shares               Price
---------                                   ---------               -----
<S>                                          <C>               <C>
The Timken Living Trust
U/A/D 9/14/99                                   83,334            $250,002

Narragansett Offshore Ltd.                      83,334              67,200

Cypress VI Partners                             33,333              99,999

TOTAL                                        3,666,668         $11,000,004

</TABLE>

<PAGE>

                                                                  March 31, 2000

                                    EXHIBIT B

                             SCHEDULE OF EXCEPTIONS

         The following are exceptions to the representations and warranties of
the Company set forth in that certain Subscription Agreement dated as of March
___, 2000 (the "Agreement"), with reference to subsection designations of the
Agreement. The reference to specific subsections is not meant and should not be
construed as limiting the noted exceptions to that particular subsection. Any
exception noted below is deemed disclosed for all purposes of all relevant
subsections whether or not cross-referenced.

Section 3: Reference is made to the Company's filings with the Securities and
Exchange Commission, its press releases posted on the Company's web site at
WWW.TREGA.COM under "new releases" as of 8 p.m. EST, March 31, 2000.

<PAGE>

                                                                DRAFT OF 3/14/00

                                    EXHIBIT C

                          OPINION OF COMPANY'S COUNSEL

To Certain Purchasers
of Common Stock of
Trega Biosciences, Inc.

Ladies and Gentlemen:

         This opinion is furnished to you pursuant to Section 5(d) of that
certain Subscription Agreement dated as of March __, 2000 between Trega
Biosciences, Inc., a Delaware corporation (the "Company") and you (the
"Agreement"). We have acted as counsel for the Company in connection with the
proposed issuance by the Company of an aggregate of _____________ shares of its
common stock, $.001 par value ("Common Stock") to you (collectively, hereinafter
referred to as the "Purchasers") and in the amounts set forth on Exhibit A to
the Agreement, pursuant to the terms of the Agreement. The shares of Common
Stock sold to the Purchasers are herein referred to as the "Shares."

         We have examined the Restated Certificate of Incorporation of the
Company and Bylaws of the Company and such other documents and certificates of
public officials and representatives of the Company as we have deemed necessary
as a basis for the opinions expressed herein. As to questions of fact material
to such opinions, we have, when relevant facts were not independently
established, relied in certain instances upon certificates of officers of the
Company.

         We have assumed the genuineness of all signatures and documents
submitted as originals, that all copies submitted to us conform to the
originals, the legal capacity of all natural persons, and, as to documents
executed by entities other than the Company, that such documents have been duly
authorized, executed and delivered by, and are binding upon and enforceable
against, such entities.

         We express no opinion as to the laws of any jurisdiction other than the
State of California and the United States and the General Corporation Law of the
State of Delaware, nor as to the qualification of the Shares under the
securities or blue sky laws of any jurisdiction other than the State of
California.

         Based upon the foregoing and subject to the qualifications set forth
below, it is our opinion that:

         1. The Company is a corporation duly incorporated, and validly existing
under the laws of the State of Delaware.

<PAGE>

         2. The Shares will, if issued pursuant to the terms of the Agreement
against payment of the consideration set forth in the Agreement and when fully
paid for as provided therein, be validly issued, fully paid and non-assessable.

         3. The issuance of the Shares, when issued pursuant to the terms of the
Agreement, will be exempt from the qualification requirements of Section 25110
of the California Corporate Securities Law of 1968, as amended (the "CSL")
pursuant to the exemption afforded by Section 25100(o) of the CSL and pursuant
to Section 18 of the Securities Act of 1933, as amended (the "1933 Act").

         4. Based in part on the representations of the Purchasers and assuming
that the manner in which the offering of such Shares was conducted was in all
respects in compliance with the requirements of Regulation D promulgated under
the 1933 Act, the issuance of the Shares, when issued pursuant to the terms of
the Agreement, will be exempt from the registration requirements of the 1933
Act.

         5. The issuance of the Shares will not materially conflict with,
violate or result in a material breach of, the terms, conditions or provisions
of, or constitute a material default under the Restated Certificate of
Incorporation or Bylaws of the Company.

         We express no opinion as to compliance with applicable anti-trust or
anti-fraud statutes or rules or regulations of any applicable law governing the
issue of securities.

         For purposes of rendering the opinion in paragraph 3 above, we assume
that (i) the Company's Common Stock continues to be designated as a Nasdaq
National Market security and (ii) the exemption afforded by Section 25100(o) of
the CSL continues to be available to securities designated as Nasdaq National
Market securities.

         This opinion is rendered solely for your information in connection with
the appointment described above and may not be relied upon by any other person
for any purpose without our prior written consent.

                                                              Very truly yours<PAGE>

         VOID AFTER 5:00 P.M., CALIFORNIA TIME,
         ON APRIL 11, 2005

         THIS WARRANT AND THE SHARES ISSUABLE UPON EXERCISE OF THIS WARRANT HAVE
         NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
         "SECURITIES ACT"), OR THE SECURITIES LAWS OF ANY STATE OF THE UNITED
         STATES OR ANY OTHER JURISDICTION. THE SECURITIES REPRESENTED HEREBY MAY
         NOT BE OFFERED OR SOLD IN THE ABSENCE OF AN EFFECTIVE REGISTRATION
         STATEMENT FOR THE SECURITIES UNDER APPLICABLE SECURITIES LAWS UNLESS
         OFFERED, SOLD OR TRANSFERRED PURSUANT TO AN AVAILABLE EXEMPTION FROM
         THE REGISTRATION REQUIREMENTS OF THOSE LAWS.

Date:    April 11, 2000

                             TREGA BIOSCIENCES, INC.
                             STOCK PURCHASE WARRANT

            THIS WARRANT CERTIFIES THAT, for value received, FIRST SECURITY VAN
KASPER or its registered assigns (the "Holder") is entitled to purchase from
TREGA BIOSCIENCES, INC., a corporation organized under the laws of the State of
Delaware (the "Company"), at any time or from time to time during the period
specified in Section 2 hereof, 220,000 fully paid and nonassessable shares of
the Company's common stock, $.001 par value (the "Common Stock"), at an exercise
price of $5.375 per share (the "Exercise Price"). The number of shares of Common
Stock purchasable hereunder (the "Warrant Shares") and the Exercise Price are
subject to adjustment as provided in Section 5 hereof.

            This Warrant is subject to the following terms, provisions and
conditions:

            1. MANNER OF EXERCISE; ISSUANCE OF CERTIFICATES; PAYMENT FOR SHARES.
Subject to the provisions hereof, including, without limitation, the limitations
contained in Section 8 hereof, this Warrant may be exercised at any time during
the Exercise Period (as defined below) by the Holder hereof, in whole or in
part, by the surrender of this Warrant, together with a completed exercise
agreement in the form attached hereto (the "Exercise Agreement"), to the Company
by 5 p.m. California time

                                      -1-
<PAGE>

on any Business Day (as defined below) at the Company's principal executive
offices (or such other office or agency of the Company as it may designate by
notice to the Holder hereof) and upon: (i) payment to the Company in cash, by
certified or official bank check or by wire transfer for the account of the
Company, of the applicable Exercise Price for the Warrant Shares specified in
the Exercise Agreement; or (ii) delivery to the Company of written notice of an
election to effect a Cashless Exercise (as defined in Section 11(c) hereof) for
the Warrant Shares specified in the Exercise Agreement. The Warrant Shares so
purchased shall be deemed to be issued to the Holder hereof or such Holder's
designee, as the record owner of such shares, as of the close of business on the
date on which this Warrant shall have been surrendered and the completed
Exercise Agreement shall have been delivered and payment shall have been made
for such shares as set forth above or, if such day is not a Business Day, on the
next succeeding Business Day. The Warrant Shares so purchased, representing the
aggregate number of shares specified in the Exercise Agreement, shall be
delivered to the Holder hereof within a reasonable time, not exceeding five
Business Days, after this Warrant shall have been so exercised (the "Delivery
Period").

            If the Company's transfer agent is participating in the Depository
Trust Company ("DTC") Fast Automated Securities Transfer program, and so long as
the certificate(s) does not bear a legend and the Holder is not obligated to
return such certificate for the placement of a legend thereon, the Company shall
cause its transfer agent to electronically transmit the Warrant Shares so
purchased to the Holder by crediting the account of the Holder or its nominee
with DTC through its Deposit Withdrawal Agent Commission system ("DTC
Transfer"). If the aforementioned conditions to a DTC Transfer are not
satisfied, the Company shall deliver to the Holder physical certificate(s)
representing the Warrant Shares so purchased. Further, the Holder may instruct
the Company to deliver to the Holder the physical certificate(s) representing
the Warrant Shares so purchased in lieu of delivering such shares by way of DTC
Transfer. Any certificate(s) so delivered shall be in such denomination(s) as
may be requested by the Holder hereof, shall be registered in the name of such
Holder or such other name as shall be designated by such Holder and, following
the date on which the Warrant Shares may be sold by the Holder pursuant to Rule
144(k) promulgated under the Securities Act (or a successor rule), shall not
bear any restrictive legend. Upon a sale of any Warrant Shares pursuant to an
effective registration statement, any restrictive legend on the certificate(s)
representing such Warrant Shares shall be removed. If this Warrant shall have
been exercised only in part, then, unless this Warrant has expired, the Company
shall, at its expense, at the time of delivery of such certificates, deliver to
the Holder a new Warrant representing the number of shares with respect to which
this Warrant shall not then have been exercised.

            2. PERIOD OF EXERCISE. This Warrant may be exercised at any time or
from time to time (an "Exercise Date") during the period (the "Exercise Period")

                                      -2-
<PAGE>

beginning on the date hereof and ending at 5:00 p.m., California time, on the
fifth annual anniversary of the date of original issuance hereof.

            3. REGISTRATION RIGHTS.

              (a) DEFINITIONS. For purposes of this Section 3:

                  (i) "Register," "registered," and "registration" refer to a
registration effected by preparing and filing a registration statement in
compliance with the Securities Act, and the declaration or ordering of
effectiveness of such registration statement.

                  (ii) "Registrable Securities" means the Warrant Shares of the
Company issued or issuable upon the exercise of this Warrant.

                  (iii) "Holder" means First Security Van Kasper or any assignee
of record of such Registrable Securities to whom rights under this Section 3
have been assigned in accordance with the provisions of this Warrant.

              (b) SHELF REGISTRATION.

                  (i) The Company will file as soon as practicable, and in no
event later than 30 days after the final closing (the "Closing Date") of that
financing described in the Company's Confidential Offering Memorandum dated
March 13, 2000 and the Supplement dated March 29, 2000 and Supplement #2 dated
March 30, 2000 to such Confidential Offering Memorandum, a registration
statement with the Securities and Exchange Commission ("SEC") under the
Securities Act for the sale and distribution of all of the Holder's Registrable
Securities, and shall thereafter use its best efforts to secure the
effectiveness of such registration statement as soon as practicable.

                  (ii) The Company will pay all expenses incurred in connection
with any registration, qualification and compliance requested hereunder
(excluding underwriters' or brokers' discounts and commissions and the fees and
disbursements of counsel for Holder or any selling stockholder), including
without limitation all filing, registration and qualification, printers' and
accounting fees and the fees and disbursements of counsel for the Company.

                  (iii) The Company will use its best efforts to cause the
registration statement to remain effective until the earliest of (A) the date
ending two years after the Closing Date, (B) the date on which all the
Registrable Securities have been resold, or (C) the date on which each Holder of
Registrable Securities is able to sell all of such Holder's Registrable
Securities in a single three (3) month period without registration under the
Securities Act pursuant to Rule 144.

                                      -3-
<PAGE>

              (c) OBLIGATIONS OF THE COMPANY. In order to effect the
registration of any Registrable Securities under Section 3(b) of this Agreement,
the Company will, as expeditiously as reasonably possible:

                  (i) Prepare and file with the SEC a registration statement
with respect to such Registrable Securities and use its best efforts to cause
such registration statement to become effective, and deliver such registration
statement, at the time of such filing, to the Holder.

                  (ii) Prepare and file with the SEC such amendments and
supplements to such registration statement and the prospectus used in connection
with such registration statement as may be necessary to comply with the
provisions of the Securities Act with respect to the disposition of all
securities covered by such registration statement.

                  (iii) Furnish to Holder such number of copies of a prospectus
in conformity with the requirements of the Securities Act, and such other
documents as the Holder may reasonably request in order to facilitate the
disposition of the Registrable Securities owned by the Holder that are included
in such registration.

                  (iv) Use its best efforts to register and qualify the
securities covered by such registration statement under such other securities or
"blue sky" laws of such jurisdictions as will be reasonably requested by the
Holder, provided that the Company will not be required in connection therewith
or as a condition thereto to qualify to do business or to file a general consent
to service of process in any such states or jurisdictions.

                  (v) Notify the Holder of Registrable Securities covered by
such registration statement at any time when a prospectus relating thereto is
required to be delivered under the Securities Act of the happening of any event
as a result of which the prospectus included in such registration statement, as
then in effect, includes an untrue statement of a material fact or omits to
state a material fact required to be stated therein or necessary to make the
statements therein not misleading in the light of the circumstances then
existing, and upon such notice the Company shall use its best efforts to
promptly correct such misstatement or omission and deliver to the Holder copies
of such corrected prospectuses included in such registration statement form the
date of notice until the date of such correction. The period during which the
Company is required to keep any registration statement filed pursuant to Section
3(b) effective shall be extended for the amount of time required to amend such
registration statement and deliver such prospectus relating thereto.

              (d) FURNISH INFORMATION. It will be a condition precedent to the
obligations of the Company to take any action pursuant to Section 3(b) hereof
that the

                                      -4-
<PAGE>

Holder will furnish to the Company such information regarding the Registrable
Securities and the intended method of disposition of such securities as will be
required to effect the registration of their Registrable Securities.

              (e) INDEMNIFICATION. In the event any Registrable Securities are
included in a registration statement under Section 3(b) hereof:

                  (i) to the extent permitted by law, the Company will indemnify
and hold harmless the Holder, its partners, stockholders, officers and directors
and each person, if any, who controls such Holder within the meaning of the
Securities Act or the Securities and Exchange Act of 1934, as amended (the
"Exchange Act"), against any losses, claims, damages, or liabilities to which
they may become jointly or severally liable subject under the Securities Act,
the Exchange Act or other federal or state securities law, insofar as such
losses, claims, damages, or liabilities (or actions in respect thereof) arise
out of or are based upon any of the following statements, omissions or
violations (collectively, a "Violation"):

                    (A) any untrue statement or alleged untrue statement of a
material fact contained in such registration statement, including any
preliminary prospectus or final prospectus contained therein or any amendments
or supplements thereto;

                    (B) the omission or alleged omission to state therein a
material fact required to be stated therein, or necessary to make the statements
therein not misleading; or

                    (C) any violation or alleged violation by the Company of the
Securities Act, the Exchange Act, any federal or state securities law or any
rule or regulation promulgated under the Securities Act, the Exchange Act or any
federal or state securities law in connection with the offering covered by such
registration statement; and the Company will reimburse the Holder, each partner,
stockholder, officer or director, underwriter or controlling person of the
Holder for any legal or other expenses reasonably incurred by them, as incurred,
in connection with investigating or defending any such loss, claim, damage,
liability or action; provided however, that the indemnity agreement contained in
this Section 3(e)(i) will not apply to amounts paid in settlement of any such
loss, claim, damage, liability or action if such settlement is effected without
the consent of the Company (which consent will not be unreasonably withheld),
nor will the Company be liable in any such case for any such loss, claim,
damage, liability or action to the extent that it arises out of or is based upon
a Violation which occurs in reliance upon and in conformity with written
information furnished expressly for use in connection with such registration by
the Holder and each partner, stockholder, officer, director or controlling
person of such Holder.

                                      -5-
<PAGE>

                  (ii) To the extent permitted by law, the Holder will indemnify
and hold harmless the Company, each of its directors, each of its officers who
have signed the registration statement, each person, if any, who controls the
Company within the meaning of the Securities Act, any underwriter and any other
party selling securities under such registration statement or any of such other
party's partners, directors or officers or stockholders or any person who
controls such party within the meaning of the Securities Act or the Exchange
Act, against any losses, claims, damages or liabilities (joint or several) to
which the Company or any such partner, director, officer, stockholder or
controlling person of such other party may become subject under the Securities
Act, the Exchange Act or other federal or state law, insofar as such losses,
claims, damages or liabilities (or actions in respect thereto) arise out of or
are based upon any Violation that arises solely as a result of written
information furnished by the Holder expressly for use in connection with such
registration; and the Holder will reimburse any legal or other expenses
reasonably incurred by the Company or any partner, officer, director,
stockholder or controlling person of such party in connection with investigating
or defending any such loss, claim, damage, liability or action; provided,
however, that the indemnity agreement contained in this Section 3(e)(ii) will
not apply to amounts paid in settlement of any such loss, claim, damage,
liability or action if such settlement is effected without the consent of the
Holder, which consent will not be unreasonably withheld; and provided further,
that the total amounts payable in indemnity by the Holder under this Section
3(e)(ii) in respect of any Violation will not exceed the aggregate proceeds (net
of discounts) received by the Holder upon the sale of the Warrant Shares.

                  (iii) Promptly after receipt by an indemnified party under
this Section 3(e) of notice of the commencement of any action (including any
governmental action), such indemnified party will, if a claim in respect thereof
is to be made against any indemnifying party under this Section 3(e), deliver to
the indemnifying party a written notice of the commencement thereof and the
indemnifying party will have the right to participate in, and, to the extent the
indemnifying party so desires, jointly with any other indemnifying party
similarly noticed, to assume the defense thereof with counsel mutually
satisfactory to the parties; provided, however, that an indemnified party will
have the right to retain its own counsel, with the fees and expenses to be paid
by the indemnifying party, if representation of such indemnified party by the
counsel retained by the indemnifying party would by inappropriate due to actual
differing interests between such indemnified party and any other party
represented by such counsel in such proceeding. The failure to deliver written
notice to the indemnifying party within a reasonable time of the commencement of
any such action, if the indemnifying party is materially prejudiced thereby,
will relieve such indemnifying party of liability, but only to the extent that
such indemnifying party is prejudiced with respect to a specific claim.

                                      -6-
<PAGE>

                  (iv) The foregoing indemnity agreement with respect to any
prospectus shall not inure to the benefit of the Holder, or any person
controlling such Holder, from whom the person asserting any losses, claims,
damages or liabilities purchased Registrable Securities, if a copy of the
prospectus (as then amended or supplemented if the Company shall have furnished
any amendments or supplements thereto) provided by the Company was not sent or
given by or on behalf of such Holder to such person, if required by law so to
have been delivered, at or prior to the written confirmation of the sale of the
Registrable Securities to such person, and if the prospectus (as so amended or
supplemented) would have cured the defect giving rise to such loss, claim,
damage or liability.

                  (v) If the indemnification provided for in Sections 3(e)(i) or
3(e)(ii) hereof shall be unavailable to hold harmless an indemnified party in
respect of any liability under the Securities Act, then, and in each such case,
the indemnifying party, in lieu of indemnifying such indemnified party
hereunder, shall contribute to the amount paid or payable by such indemnified
party as a result of such loss, liability, claim, damage or expense in such
proportion as is appropriate to reflect the relative fault of the indemnifying
party on the one hand and of the indemnified party on the other in connection
with the statement or omissions that resulted in such loss, liability, claim,
damage or expense as well as any other relevant equitable consideration. The
relative fault of the indemnifying party and of the indemnified party shall be
determined by reference to, among other things, whether the untrue or alleged
untrue statement of a material fact or the omission to state a material fact
relates to information supplied by the indemnifying party or by the indemnified
party and the parties' relative intent, knowledge, access to information and
opportunity to correct or prevent such statement or omission; provided that in
no event shall any contribution under this subsection (v) by the Holder exceed
the gross proceeds from the offering received by such indemnifying party. No
person or entity guilty of fraudulent misrepresentation (within the meaning of
Section 11(f) of the Securities Act) will be entitled to contribution from any
person or entity who was not guilty of such fraudulent misrepresentation.

                  (vi) The obligations of the Company and the Holder under this
Section 3(e) will survive the completion of any offering of Registrable
Securities in a registration statement, and otherwise.

              (f) RULE 144 REPORTING. With a view to making available the
benefits of certain rules and regulations of the SEC which may at any time
permit the sale of the Registrable Securities to the public without
registration, while a public market exists for the Common Stock of the Company,
the Company will:

                  (i) Make and keep public information available, as those terms
are understood and defined in Rule 144 under the Securities Act, at all times
while the Company is reporting under the Exchange Act;

                                      -7-
<PAGE>

                  (ii) Use its best efforts to file with the SEC in a timely
manner all reports and other documents required of the Company under the
Securities Act and the Exchange Act (at any time it is subject to such reporting
requirements); and

                  (iii) So long as Holder owns any Registrable Securities,
furnish to the Holder forthwith upon request a written statement by the Company
as to its compliance with the reporting requirements of Rule 144, and of the
Securities Act and the Exchange Act (at any time it is subject to the reporting
requirements of the Exchange Act), a copy of the most recent annual or quarterly
report of the Company, and such other reports and documents of the Company as a
Holder may reasonably request in availing itself of any rule or regulation of
the SEC allowing a Holder to sell any such securities without registration (at
any time the Company is subject to the reporting requirements of the Exchange
Act).

              (g) If Holder shall propose to sell any Registrable Securities
pursuant to the registration statement, Holder shall notify the Company of its
intent to do so at least three (3) full Business Days prior to such sale. Such
notice shall be deemed to constitute a representation that any written
information previously supplied by Holder is accurate as of the date of such
notice. At any time within such three (3) Business Day period, the Company may
notify the Holder that the Company will refuse to permit the Holder to resell
any Registrable Securities pursuant to the registration statement for an initial
period not to exceed thirty (30) day; PROVIDED, HOWEVER, that in order to
exercise this right, the Company must deliver a certificate in writing to the
Holder to the effect that a delay in such sale is necessary because a sale
pursuant to such registration statement in its then-current form would not be in
the best interest of the Company and its stockholders due to disclosure
obligations of the Company. In such event, the Company shall use its best
efforts to amend the registration statement, if necessary, and to take all other
actions reasonably necessary to allow such sale, and shall notify the Holder
promptly after it has determined that such sale has become permissible.
Notwithstanding the foregoing, the Company shall not be entitled to exercise
its right to refuse to permit a sale by the Holder more than three (3) times in
any calendar year PROVIDED, HOWEVER, that the Holder will not be refused
permission to sell under this Section 3(g) at the same time that another party
is permitted to sell under the registration statement. The Holder hereby
covenants and agrees that it will not sell any Registrable Securities pursuant
to the registration statement during the periods the registration statement is
withdrawn as set forth in this Section 3(g).

              (h) FURTHER INFORMATION. The Holder covenants that it will
promptly notify the Company of any changes in the information set forth in the
registration statement regarding such Holder or the Holder's plan of
distribution.

                                      -8-
<PAGE>

            4. CERTAIN AGREEMENTS OF THE COMPANY. The Company hereby covenants
and agrees as follows:

              (a) SHARES TO BE FULLY PAID. All Warrant Shares will, upon
issuance in accordance with the terms of this Warrant, be validly issued, fully
paid and nonassessable and free from all taxes, liens, claims and encumbrances.

              (b) RESERVATION OF SHARES. During the Exercise Period, the Company
shall at all times have authorized, and reserved for the purpose of issuance
upon exercise of this Warrant, a sufficient number of shares of Common Stock to
provide for the exercise in full of this Warrant.

              (c) LISTING. The Company shall secure the listing of the shares of
Common Stock issuable upon exercise of or otherwise pursuant to this Warrant
upon each national securities exchange or automated quotation system, if any,
upon which shares of Common Stock are then listed or become listed (subject to
official notice of issuance upon exercise of this Warrant) and shall maintain,
so long as any other shares of Common Stock shall be so listed, such listing of
all shares of Common Stock from time to time issuable upon the exercise of or
otherwise pursuant to this Warrant; and the Company shall so list on each
national securities exchange or automated quotation system, as the case may be,
and shall maintain such listing of, any other shares of capital stock of the
Company issuable upon the exercise of or otherwise pursuant to this Warrant if
and so long as any shares of the same class shall be listed on such national
securities exchange or automated quotation system.

              (d) CERTAIN ACTIONS PROHIBITED. The Company will not, by amendment
of its charter or through any reorganization, transfer of assets, consolidation,
merger, dissolution, issuance or sale of securities, or any other voluntary
action, avoid or seek to avoid the observance or performance of any of the terms
to be observed or performed by it hereunder, but will at all times in good faith
assist in the carrying out of all the provisions of this Warrant. Without
limiting the generality of the foregoing, the Company: (i) will not increase the
par value of any shares of Common Stock receivable upon the exercise of this
Warrant above the Exercise Price then in effect; and (ii) will take all such
actions as the Company shall reasonably determine to be necessary or appropriate
in order that the Company may validly and legally issue fully paid and
nonassessable shares of Common Stock upon the exercise of this Warrant.

              (e) SUCCESSORS AND ASSIGNS. This Warrant will be binding upon any
entity succeeding to the Company by merger, consolidation, or acquisition of all
or substantially all of the Company's assets.

              (f) BLUE SKY LAWS. The Company shall, on or before the date of
issuance of any Warrant Shares, take such actions as the Company shall
reasonably

                                      -9-
<PAGE>

determine are necessary to qualify the Warrant Shares for, or obtain exemption
for the Warrant Shares for, sale to the Holder of this Warrant upon the exercise
hereof under applicable securities or "blue sky" laws of the states of the
United States, and shall provide evidence of any such action so taken to the
Holder of this Warrant prior to such date; provided, however, that the Company
shall not be required to qualify as a foreign corporation or file a general
consent to service of process in any such jurisdiction; provided, further, that
Holder makes such representations and warranties as may be required to obtain
such qualification or exemption.

            5. ANTIDILUTION PROVISIONS. During the Exercise Period, the Exercise
Price and the number of Warrant Shares issuable upon the exercise of the
Warrants, shall be subject to adjustment from time to time as provided in this
Section 5.

            In the event that any adjustment of the Exercise Price as required
herein results in a fraction of a cent, such Exercise Price shall be rounded up
or down to the nearest cent; provided that, in no event shall the Exercise Price
per share be reduced below $.01.

              (a) SUBDIVISION OR COMBINATION OF COMMON STOCK. If the Company, at
any time during the Exercise Period, subdivides (by any stock split, stock
dividend, recapitalization, reorganization, reclassification or otherwise) its
shares of Common Stock into a greater number of shares, then, after the date of
record for effecting such subdivision, the Exercise Price in effect immediately
prior to such subdivision will be proportionately reduced. If the Company, at
any time during the Exercise Period, combines (by reverse stock split,
recapitalization, reorganization, reclassification or otherwise) its shares of
Common Stock into a smaller number of shares, then, after the date of record for
effecting such combination, the Exercise Price in effect immediately prior to
such combination will be proportionately increased.

              (b) ADJUSTMENT IN NUMBER OF SHARES. Upon each adjustment of the
Exercise Price pursuant to the provisions of this Section 5, the number of
shares of Common Stock issuable upon exercise of this Warrant shall be increased
or decreased to equal the quotient obtained by dividing (i) the product of (a)
the Exercise Price in effect immediately prior to such adjustment, multiplied by
(b) the number of shares of Common Stock issuable upon exercise of this Warrant
immediately prior to such adjustment, by (ii) the adjusted Exercise Price.

              (c) CONSOLIDATION, MERGER OR SALE. In case of any consolidation of
the Company with, or merger of the Company into, any other entity, or in case of
any sale or conveyance of all or substantially all of the assets of the Company
other than in connection with a plan of complete liquidation of the Company at
any time during the Exercise Period, then as a condition of such consolidation,
merger or sale or conveyance, adequate provision will be made whereby the Holder
of this Warrant will have the right to acquire and receive upon exercise of this
Warrant in

                                      -10-
<PAGE>

lieu of the shares of Common Stock immediately theretofore acquirable upon
the exercise of this Warrant, such shares of stock, securities, cash or assets
as may be issued or payable with respect to or in exchange for the number of
shares of Common Stock immediately theretofore acquirable and receivable upon
exercise of this Warrant had such consolidation, merger or sale or conveyance
not taken place. In any such case, the Company will make appropriate provision
to insure that the provisions of this Section 5 will thereafter be applicable as
nearly as may be in relation to any shares of stock or securities thereafter
deliverable upon the exercise of this Warrant. The Company will not effect any
consolidation, merger or sale or conveyance unless prior to the consummation
thereof, the successor entity (if other than the Company) assumes by written
instrument the obligations under this Warrant and the obligations to deliver to
the Holder of this Warrant such shares of stock, securities or assets as, in
accordance with the foregoing provisions, the Holder may be entitled to acquire.

              (d) DISTRIBUTION OF ASSETS. In case the Company shall declare or
make any distribution of its assets (other than cash) (or rights to acquire its
assets (other than cash)) to holders of Common Stock as a partial liquidating
dividend, stock repurchase, by way of return of capital or otherwise (including
any dividend or distribution to the Company's shareholders of shares (or rights
to acquire shares) of capital stock of a subsidiary) (a "Distribution"), at any
time during the Exercise Period, then, upon exercise of this Warrant for the
purchase of any or all of the shares of Common Stock subject hereto, the Holder
of this Warrant shall be entitled to receive its pro-rata amount of such assets
(or such rights) as would have been payable to the holder had such holder been
the holder of such shares of Common Stock on the record date for the
determination of shareholders entitled to such Distribution.

              (e) NOTICE OF ADJUSTMENT. Upon the occurrence of any event which
requires any adjustment of the Exercise Price, then, and in each such case, the
Company shall give notice thereof to the Holder of this Warrant, which notice
shall state the Exercise Price resulting from such adjustment and the increase
or decrease in the number of Warrant Shares issuable upon exercise of this
Warrant, setting forth in reasonable detail the method of calculation and the
facts upon which such calculation is based. Such calculation shall be certified
by the chief financial officer of the Company.

              (f) MINIMUM ADJUSTMENT OF THE EXERCISE PRICE. No adjustment of the
Exercise Price shall be made in an amount of less than $.01 of the Exercise
Price in effect at the time such adjustment is otherwise required to be made,
but any such lesser adjustment shall be carried forward and shall be made at the
time and together with the next subsequent adjustment which, together with any
adjustments so carried forward, shall amount to not less than $.01 of such
Exercise Price.

                                      -11-
<PAGE>

              (g) NO FRACTIONAL SHARES. No fractional shares of Common Stock are
to be issued upon the exercise of this Warrant, but the Company shall pay a cash
adjustment in respect of any fractional share which would otherwise be issuable
in an amount equal to the same fraction of the Market Price of a share of Common
Stock on the date of such exercise.

              (h) CERTAIN DEFINITIONS.

                  (i) "BUSINESS DAY" means any day, other than a Saturday or
Sunday or a day on which banking institutions in the State of California are
authorized or obligated by law, regulation or executive order to close.

                  (ii) "CLOSING PRICE" shall mean for the Common Stock as of any
date, the last sale price of such security on the principal United States
securities exchange or trading market on which such security is listed or traded
as reported by the Research Service of Nasdaq Trading and Market Services (or a
comparable reporting service of national reputation selected by the Holder and
reasonably acceptable to the Company if the Research Service of Nasdaq Trading
and Market Services is not then reporting last sale prices of such security)
(collectively, "NTMS"), or if the foregoing does not apply, the last reported
sale price of such security in the over-the-counter market on the electronic
bulletin board for such security as reported by NTMS, or, if no sale price is
reported for such security by NTMS, the average of the bid prices of any market
makers for such security as reported in the "pink sheets" by the National
Quotation Bureau, Inc., in each case for such date or, if such date was not a
Trading Day (as defined below) for such security, on the next preceding day
which was a Trading Day. If the Closing Price cannot be calculated for a share
of Common Stock as of either of such dates on any of the foregoing bases, the
Closing Price of such security on such date shall be the fair market value as
determined by an investment banking firm selected by mutual agreement of the
Holder and the Company, with the costs of such appraisal to be borne equally by
the Company and the Holder. The manner of determining the Closing Price of the
Common Stock set forth in the foregoing definition shall apply with respect to
any other security in respect of which a determination as to market value must
be made.

                  (iii) "COMMON STOCK," for purposes of this Section 5, includes
the Common Stock and any additional class of stock of the Company having no
preference as to dividends or distributions on liquidation, provided that the
shares purchasable pursuant to this Warrant shall include only Common Stock in
respect of which this Warrant is exercisable, or shares resulting from any
subdivision or combination of such Common Stock, or in the case of any
reorganization, reclassification, consolidation, merger, or sale of the
character referred to in Section 5(c) hereof, the stock or other securities or
property provided for in such Section.

                                      -12-
<PAGE>

                  (iv) "MARKET PRICE" shall mean, with respect to any date of
determination, the average Closing Price during the ten (10) Trading Days ending
on the Trading Day immediately preceding such date of determination,
appropriately adjusted to reflect any stock dividend, stock split or similar
transaction during either such relevant period. The manner of determining the
Market Price of the Common Stock set forth in the foregoing definition shall
apply with respect to any other security in respect of which a determination as
to market value must be made hereunder.

                  (v) "TRADING DAY" shall mean a Business Day on which at least
1,000 shares of Common Stock are traded on the principal United States
securities exchange or trading market on which such security is listed or traded
as reported by NTMS.

            6. ISSUE TAX. The issuance of certificates for Warrant Shares upon
the exercise of this Warrant shall be made without charge to the Holder of this
Warrant or such shares for any issuance tax or other costs in respect thereof,
provided that the Company shall not be required to pay any tax which may be
payable in respect of any transfer involved in the issuance and delivery of any
certificate in a name other than the Holder of this Warrant.

            7. NO RIGHTS OR LIABILITIES AS A SHAREHOLDER. This Warrant shall not
entitle the Holder hereof to any voting rights or other rights as a shareholder
of the Company. No provision of this Warrant, in the absence of affirmative
action by the Holder hereof to purchase Warrant Shares, and no mere enumeration
herein of the rights or privileges of the Holder hereof, shall give rise to any
liability of such Holder for the Exercise Price or as a shareholder of the
Company, whether such liability is asserted by the Company or by creditors of
the Company.

            8. TRANSFER; EXCHANGE; REDEMPTION AND REPLACEMENT OF WARRANT.

              (a) RESTRICTION ON TRANSFER. This Warrant and the rights granted
to the Holder hereof are transferable up to ten of the Holder's employees in
whole or in part, at any one time, upon surrender of this Warrant, together with
a properly executed assignment in the form attached hereto, at the office or
agency of the Company referred to in Section 8(e) below, provided, however, that
any transfer or assignment shall be subject to the conditions set forth in
Section 8 hereof. Until due presentment for registration of transfer on the
books of the Company, the Company may treat the registered Holder hereof as the
owner and Holder hereof for all purposes, and the Company shall not be affected
by any notice to the contrary. Notwithstanding anything to the contrary
contained herein, the registration rights described in Section 3 hereof are
assignable only to up to ten of the Holder's employees in accordance with the
provisions of Section 3.

                                      -13-
<PAGE>

              (b) WARRANT EXCHANGEABLE FOR DIFFERENT DENOMINATIONS. This Warrant
is exchangeable, upon the surrender hereof by the Holder hereof at the office or
agency of the Company referred to in Section 8(e) below, for new Warrants of
like tenor of different denominations representing in the aggregate the right to
purchase the number of shares of Common Stock which may be purchased hereunder,
each of such new Warrant to represent the right to purchase such number of
shares as shall be designated by the Holder hereof at the time of such
surrender. No new Warrant shall be issued for a denomination that is less than
12,500 shares of Common Stock.

              (c) REPLACEMENT OF WARRANT. Upon receipt of evidence reasonably
satisfactory to the Company of the loss, theft, destruction, or mutilation of
this Warrant and, in the case of any such loss, theft, or destruction, upon
delivery of an indemnity agreement and/or bond reasonably satisfactory in form
and amount to the Company, or, in the case of any such mutilation, upon
surrender and cancellation of this Warrant, the Company, at its expense, will
execute and deliver, in lieu thereof, a new Warrant of like tenor.

              (d) CANCELLATION: PAYMENT OF EXPENSES. Upon the surrender of this
Warrant in connection with any transfer, exchange, or replacement as provided in
this Section 8, this Warrant shall be promptly canceled by the Company. The
Holder shall pay all taxes and all other expenses and charges payable in
connection with the preparation, execution, and delivery of Warrants pursuant to
this Section 8.

              (e) WARRANT REGISTER. The Company shall maintain, at its principal
executive offices (or such other office or agency of the Company as it may
designate by notice to the Holder hereof), a register for this Warrant, in which
the Company shall record the name and address of the person in whose name this
Warrant has been issued, as well as the name and address of each transferee and
each prior owner of this Warrant.

              (f) EXERCISE OR TRANSFER WITHOUT REGISTRATION. If, at the time of
the surrender of this Warrant in connection with any exercise, transfer, or
exchange of this Warrant, this Warrant (or, in the case of any exercise, the
Warrant Shares issuable hereunder), shall not be registered under the Securities
Act and under applicable state securities or blue sky laws, the Company may
require, as a condition of allowing such exercise, transfer, or exchange, (i)
that the Holder of this Warrant furnish to the Company a written opinion of
counsel, reasonably satisfactory to the Company stating that such exercise,
transfer, or exchange may be made without registration under the Securities Act
and under applicable state securities or blue sky laws, (ii) that the holder or
transferee execute and deliver to the Company an investment letter in form and
substance reasonably acceptable to the Company and (iii) that the transferee be
an "accredited investor" as defined in Rule 501(a) promulgated under the
Securities Act; provided that no such opinion, letter, or status

                                      -14-
<PAGE>

as an "accredited investor" shall be required in connection with a transfer
pursuant to Rule 144 under the Securities Act.

            9. NOTICES. Any notices required or permitted to be given under the
terms of this Warrant shall be sent by certified or registered mail (return
receipt requested) or delivered personally or by courier or by confirmed
telecopy, and shall be effective five days after being placed in the mail, if
mailed, or upon receipt or refusal of receipt, if delivered personally or by
courier, or by confirmed telecopy, in each case addressed to a party. The
addresses for such communications shall be:

<TABLE>

                  <S>                            <C>
                  If to the Company:             TREGA BIOSCIENCES, INC.
                                                 9880 Campus Point Drive
                                                 San Diego, CA 92121
                                                 Telephone No.:  858-410-6500
                                                 Facsimile No.:  858-410-6501
                                                 Attention:  Chief Executive Officer

                  With a copy to:                Pillsbury Madison & Sutro LLP
                                                 50 Fremont Street
                                                 San Francisco, CA 94105
                                                 Telephone No.:  415-983-1000
                                                 Facsimile No.:  415-983-1200
                                                 Attention:  Thomas E. Sparks
</TABLE>

If to the Holder, at such address as such Holder shall have provided in
writing to the Company, or at such other address as such holder furnishes by
notice given in accordance with this Section 9, and, for any notice under
Section 3, with a copy to:

                          First Security Van Kasper
                          Telephone No.: (310) 443-3403
                          Facsimile No.: (310) 443-3400
                          Attention: David H. Horwich
                                     Senior Vice President
                                     Corporate Finance

            10. GOVERNING LAW; JURISDICTION. This Warrant shall be governed by
and construed in accordance with the laws of the State of California applicable
to contracts made and to be performed in the State of California. Each of the
Company and the Holder irrevocably consents to the jurisdiction of the United
States federal courts and state courts located in the State of California in any
suit or proceeding based on or arising under this Warrant and irrevocably agrees
that all claims in respect of such suit or proceeding may be determined in such
courts.

                                      -15-
<PAGE>

            11. MISCELLANEOUS.

              (a) AMENDMENTS. Except as provided in Section 8(g) hereof, this
Warrant and any provision hereof may only be amended by an instrument in writing
signed by the Company and the Holder hereof.

              (b) DESCRIPTIVE HEADINGS. The descriptive headings of the several
Sections of this Warrant are inserted for purposes of reference only, and shall
not affect the meaning or construction of any of the provisions hereof.

              (c) CASHLESS EXERCISE. This Warrant may be exercised at any time
or from time to time during the Exercise Period, by presentation and surrender
of this Warrant to the Company at its principal executive offices with a written
notice of the Holder's intention to effect a cashless exercise, including a
calculation of the number of shares of Common Stock to be issued upon such
exercise in accordance with the terms hereof (a "Cashless Exercise"). In the
event of a Cashless Exercise in lieu of paying the Exercise Price in cash, the
holder shall surrender this Warrant for that number of shares of Common Stock
determined by multiplying (i) the number of Warrant Shares to which it would
otherwise be entitled by (ii) a fraction, the numerator of which shall be the
difference between the then current Market Price per share of the Common Stock
and the Exercise Price, and the denominator of which shall be the Market Price
per share of Common Stock.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                      -16-
<PAGE>

              IN WITNESS WHEREOF, the Company has caused this Warrant to be
signed by its duly authorized officer.

                                       TREGA BIOSCIENCES, INC.

                                       By: /s/ Michael G. Grey
                                          ------------------------
                                       Name: Michael G. Grey
                                            ----------------------
                                       Title: President and CEO
                                             ---------------------

                                      -17-
<PAGE>

                           FORM OF EXERCISE AGREEMENT

         (TO BE EXECUTED BY THE HOLDER IN ORDER TO EXERCISE THE WARRANT)

To:      TREGA BIOSCIENCES, INC.

         Telephone No.: 858-410-6500
         Facsimile No.: 858-410-6501
         Attention: General Counsel

              The undersigned hereby irrevocably exercises the right to purchase
______________ shares of the Common Stock of TREGA BIOSCIENCES, INC., a
corporation organized under the laws of the State of Delaware (the "Company"),
and either:

/ /   tenders herewith payment of the Exercise Price in full, in the amount
      of $_______________ in cash, by certified or official bank check or by
      wire transfer for the account of the Company; or

/ /   elects pursuant to Section 11(c) of the Warrant to convert such Warrant
      into Common Stock on a cashless exercise basis.

              The undersigned agrees not to offer, sell, transfer or otherwise
dispose of any Common Stock obtained on exercise of the Warrant, except under
circumstances that will not result in a violation of the Securities Act of 1933,
as amended, or any state securities laws.

/ /   The undersigned requests that the Company cause its transfer agent to
      electronically transmit the Common Stock issuable pursuant to this
      Exercise Agreement to the account of the undersigned or its nominee (which
      is) with DTC through its Deposit Withdrawal Agent Commission System ("DTC
      Transfer").

/ /   In lieu of receiving the shares of Common Stock issuable pursuant to this
      Exercise Agreement by way of DTC Transfer, the undersigned hereby requests
      that the Company cause its transfer agent to issue and deliver to the
      undersigned physical certificates representing such shares of Common
      Stock.

                                      -18-
<PAGE>

              The undersigned requests that a Warrant representing any
unexercised portion hereof be issued, pursuant to the Warrant, in the name of
the Holder and delivered to the undersigned at the address set forth below:

Dated:
      ---------------------------              ------------------------------
                                               Signature of Holder

                                                ------------------------------
                                                Name of Holder (Print)

                                                Address:

                                                -------------------------------

                                      -19-
<PAGE>

                               FORM OF ASSIGNMENT

              FOR VALUE RECEIVED, the undersigned hereby sells, assigns, and
transfers all the rights of the undersigned under the attached Warrant, with
respect to the number of shares of Common Stock covered thereby issuable
pursuant to the attached Warrant set forth hereinbelow, to:

NAME OF ASSIGNEE                ADDRESS                 NO. OF SHARES

and hereby irrevocably constitutes and appoints __________________________ as
agent and attorney-in-fact to transfer said Warrant on the books of the
within-named corporation, with full power of substitution in the premises.

Dated:
      -----------------------,

In the presence of                          Name:
                                                 --------------------------
                                               Signature:
      -----------------------                            -------------------
                                               Title of Signing Officer or
                                               Agent (if any):

                                            Address:
                                                    ------------------------

                                            Note:  The above signature should
                                            correspond exactly with the name on
                                            the face of the within Warrant.

                                      -20-

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