Document:

EX-10.1

 Exhibit 10.1 

PREFERRED STOCK EQUITY FACILITY AGREEMENT 

This PREFERRED STOCK EQUITY FACILITY AGREEMENT (the “Agreement”) is made and entered into as of the 16th day of October 2017 (the “Effective Date”) by and between Kapital Joe, LLC (the “Investor”) and Intrexon Corporation, a Virginia corporation (the
“Company”). 
 WHEREAS, the parties desire to provide that, upon the terms and subject to the conditions
contained herein, the Company may issue and sell to the Investor, from time to time as provided herein, and the Investor shall purchase from the Company, up to $100 million of the Company’s Series A Redeemable Preferred Stock, no par value per
share (the “Preferred Stock”), at a purchase price per share of Preferred Stock of $100.00, as adjusted equitably for any split, subdivision, combination, consolidation, recapitalization or similar event with respect to the
Preferred Stock (the “Purchase Price”); and 
 WHEREAS, such investments will be made in reliance upon the
provisions of Regulation D (“Regulation D”) of the Securities Act of 1933, as amended, and the regulations promulgated thereunder (the “Securities Act”), and or upon such other exemption from the registration
requirements of the Securities Act as may be available with respect to any or all of the investments to be made hereunder. 
 NOW,
THEREFORE, the parties hereto agree as follows: 
 ARTICLE I 

DEFINITIONS AND OTHER MATTERS 

Section 1.1 Defined Terms. As used in this Agreement, the following terms shall have the following meanings. Other capitalized
terms are defined elsewhere herein 
 “Affiliate” of any specified Person shall mean any other Person directly or
indirectly controlling or controlled by or under common control with such specified Person. For the purposes of this definition, “control” when used with respect to any specified Person means the power to direct the management and policies
of such Person, directly or indirectly, whether through the ownership of voting securities, by contract or otherwise; and the terms “controlling” and “controlled” have meanings correlative to the foregoing. 

“Articles of Amendment” shall mean the Articles of Amendment setting forth the terms, including the preferences,
rights and limitations, of the Preferred Stock, in the form attached hereto as Exhibit A, to be filed with the SCC on or after the Effective Date. 

“Business Day” shall mean any day other than a Saturday, Sunday or a day on which state or federally chartered banking
institutions in New York, New York are authorized or required to be closed. 
 “Commitment Amount” shall mean
the aggregate amount of up to $100 million which the Investor has agreed to provide to the Company in order to purchase the Company’s Preferred Stock pursuant to the terms and conditions of this Agreement. 

 “Commitment Period” shall mean the period commencing on the Effective
Date and expiring on the earliest to occur of: (i) the date on which the Investor shall have made purchases of Preferred Stock pursuant to this Agreement in the aggregate amount of $100 million, (ii) April 30, 2019, (iii) the
date that the shareholders of the Company approve the conversion of the Preferred Stock into shares of Common Stock in accordance with NYSE rules and (iv) the mutual agreement of the parties. 

“Common Stock” shall mean the Company’s common stock, no par value per share. 

“Contractual Obligation” shall mean, as to any Person, any provision of any security issued by such Person or of any
contract, agreement, instrument or other undertaking to which such Person is a party or by which it or any of its property is bound. 

“Conversion Stock” shall mean only those shares of Common Stock (or equity securities of any successor to the Company,
as the case may be), which may be received by the Investor upon conversion of Preferred Stock in accordance with the terms hereof and the Articles of Amendment. 

“Exchange Act” shall mean the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated
thereunder. 
 “Governmental Authority” shall mean any government or any state, department or other political
subdivision thereof, or any governmental body, agency, authority or instrumentality in any jurisdiction exercising executive, legislative, regulatory or administrative functions of or pertaining to government. 

“NYSE” shall mean the New York Stock Exchange. 

“Permitted Transferee” shall mean (a) with respect to an Investor who is an individual to (i) the spouse or
any lineal descendant (including adopted children) of such Investor, (ii) any trust, or wholly owned limited partnership, limited liability company or corporation for the benefit of such Investor or the spouse or lineal descendant (including
adopted children) of such Investor; provided that such individual (together with the members of his or her immediate family) retains voting control with respect to the Preferred Stock so Transferred, or (iii) the estate of such Investor, and
(b) with respect to an Investor which is an entity, to any Affiliate of such Investor. 
 “Person” shall
mean any individual, firm, partnership, corporation or other entity and shall include any successor (by merger or otherwise) of such entity. 

“Put” shall mean the portion of the Commitment Amount requested by the Company in the Put Notice. 

“Put Date” shall mean the date the Company is in receipt of the funds from the Investor. No Put Date shall be more
than five Business Days after a Put Notice Date. 
 “Put Notice” shall mean a written notice to the Investor
setting forth the Put amount that the Company requires from the Investor and the proposed Put Date. 

  
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 “Put Notice Date” shall mean each date the Company delivers to the
Investor a Put Notice requiring the Investor to provide funds to the Company, subject to the terms of this Agreement. 

“Requirement of Law” shall mean as to any Person, the certificate of incorporation and by-laws or other organizational
or governing documents of such Person, and any law, treaty, rule or regulation or determination of an arbitrator or a court or other Governmental Authority, in each case applicable to or binding upon such Person or any of its material property or to
which such Person or any of its material property is subject. 
 “SCC” shall mean the State
Corporation Commission of the Commonwealth of Virginia. 
 “SEC” shall mean the Securities and Exchange Commission. 

“SEC Documents” shall mean all filings made by the Company with the SEC under the Securities Act and the Exchange Act,
including all exhibits thereto. 
 “Shareholder Approval” shall mean the shareholder approval necessary to
approve the conversion of the Preferred Stock into Common Stock for purposes of Section 312.03 of the New York Stock Exchange Listed Company Manual, which approval shall include a majority of the votes cast by holders of Common Stock other than
the votes cast by holders of Common Stock who, at such time, are holders of Preferred Stock, or Affiliates of such holders. 

“Transfer” shall mean a sale, transfer, hypothecation, assignment, gift, bequest or disposition by any other means,
whether for value or no value and whether voluntary or involuntary (including, without limitation, by realization upon any lien or by operation of law or by judgment, levy, attachment, garnishment, bankruptcy or other legal or equitable
proceedings). 
 ARTICLE II 

ADVANCES 
 Section 2.1
General. Upon the terms and conditions set forth in this Agreement, on any Put Notice Date the Company may require the Investor to purchase shares of Preferred Stock by the delivery of a Put Notice. The number of shares of Preferred Stock
that the Investor shall purchase with each Put shall be determined by dividing the amount of the Put by the Purchase Price. Each Put must be in multiples of $100; no fractional shares shall be issued. The aggregate maximum amount of all purchases
that the Investor shall be obligated to make under this Agreement in connection with Puts shall not exceed the Commitment Amount. 

Section 2.2 Mechanics. 

(a) Put Notice. At any time during the Commitment Period, the Company may deliver a Put Notice to the Investor, subject to the
conditions set forth in this Agreement. 
 (b) Date of Delivery of Put Notice. A Put Notice shall be deemed delivered on the Business
Day it is received by facsimile or email by the Investor if such notice is received prior to 5:00 pm Eastern Time or the immediately succeeding Business Day if it is received by facsimile or email after 5:00 pm Eastern Time on a Business Day or at
any time on a day which is not a Business Day. 

  
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 Section 2.3 Closings. The Investor shall deliver each Put to the Company by wire
transfer of immediately available funds on the applicable Put Date as determined by the Investor, which date shall not be more than five Business Days after the applicable Put Notice Date. Within five Business Days of each such Put Date, the Company
shall deliver to the Investor the applicable number of shares of Preferred Stock (by certificate or book entry or otherwise as may be agreed to by the Company and Investor) representing the amount of the Put by the Investor pursuant to
Section 2.1 herein, registered in the name of the Investor. In addition, on or prior to the Put Date, each of the Company and the Investor shall deliver to each other all documents, instruments and writings required to be delivered by
either of them pursuant to this Agreement in order to implement and effect the transactions contemplated herein. Neither the shares of Preferred Stock nor the Common Stock delivered on conversion thereof so delivered shall be registered with the
SEC. 
 Section 2.4 Conditions to Investor’s Obligations of Closing of Puts. The obligations of the Investor to provide to
the Company the amount specified in any Put Notice delivered by the Company is subject to the fulfillment, on or before the Put Date, of the following conditions precedent, unless otherwise waived in the discretion of the Investor: 

(a) the Articles of Amendment shall have been filed with the SCC and shall be in full force and effect; 

(b) the issuance of Preferred Stock shall not violate the rules and regulations of the NYSE; 

(c) (i) the Common Stock shall be listed on the NYSE and shall not have been suspended from trading thereon, and (ii) the Company shall
not have been notified of any pending or threatened proceeding or other action to suspend the trading of the Common Stock; 
 (d) the
Company shall have obtained all material permits and qualifications required by any applicable state for the offer and sale of the Preferred Stock, or shall have the availability of exemptions therefrom, and the sale and issuance of the Preferred
Stock shall be legally permitted by all laws and regulations to which the Company is subject; 
 (e) the Company shall have filed with the
SEC all reports, notices and other documents required of a “reporting company” under the Exchange Act and applicable SEC regulations that were required to have been filed in the prior twelve months; 

(f) no injunction shall have been issued and remain in force, or action commenced by a Governmental Authority which has not been stayed or
abandoned, prohibiting the purchase or the issuance of the Preferred Stock; 
 (g) each of the representations and warranties made by the
Company pursuant to this Agreement (or in any amendment, modification or supplement hereto or thereto) shall, except to the extent that they relate to a particular date, be true and correct in all material respects on and as of such date as if made
on and as of the applicable Put Date; and 

  
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 (h) the Company shall have complied with each and every covenant and agreement applicable to it
contained in this Agreement as of the applicable Put Date. 
 ARTICLE III 

REPRESENTATIONS AND WARRANTIES OF INVESTOR 

Investor hereby represents and warrants to, and agrees with, the Company that the following are true and correct as of the date hereof and as
of each Put Date: 
 Section 3.1 Organization and Authorization. The Investor is duly incorporated or organized and validly
existing in the jurisdiction of its incorporation or organization and has all requisite power and authority to purchase and hold the securities issuable hereunder. The decision to invest and the execution and delivery of this Agreement by such
Investor, the performance by such Investor of its obligations hereunder and the consummation by such Investor of the transactions contemplated hereby have been duly authorized and requires no other proceedings on the part of the Investor. The
Investor has the right, power and authority to execute and deliver this Agreement and all related instruments. This Agreement has been duly executed and delivered by the Investor and, assuming the execution and delivery hereof and acceptance thereof
by the Company, will constitute the legal, valid and binding obligations of the Investor, enforceable against the Investor in accordance with its terms, except as enforceability may be limited by applicable bankruptcy, insolvency, reorganization,
moratorium or similar laws affecting creditors’ rights generally and except as enforceability may be subject to general principles of equity (regardless of whether such enforceability is considered in a proceeding in equity or at law). 

Section 3.2 Accredited Investor. The Investor is an “accredited investor” within the meaning of Rule 501 promulgated
under the Securities Act. 
 Section 3.3 Investment Experience; Access; Investigation. 

(a) Access to Information. The Investor, in making its investment decision hereunder, represents that: (a) it has read, reviewed
and relied solely on the publicly available information concerning the Company and any independent investigation made by it and its representatives, if any; (b) it has been afforded an opportunity to request from the Company to review, and has
received, all additional information requested from the Company, (c) it acknowledges that no person has been authorized to give any information or to make any representation concerning the Company or the Preferred Stock, other than as contained
in this Agreement, and if given or made, any such other information or representation has not been relied upon as having been authorized by the Company. 

(b) Reliance on Own Advisors. The Investor has relied completely on the advice of, or has consulted with, its own tax, investment,
legal or other advisors and has not relied on the Company, or any of its officers, directors, attorneys, accountants, representatives, agents, advisors for any advice. 

  
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 (c) Capability to Evaluate. The Investor has such knowledge and experience in financial
and business matters, either directly or through its representatives or advisors, that it is capable of evaluating the merits and risks of the prospective investment, which risks are substantial. 

(d) Ability to Bear Economic Risk. The Investor understands and acknowledges that an investment in the Preferred Stock and the
Conversion Stock involves a high degree of risk. The Investor acknowledges that it has the ability to bear the economic risk of its investment pursuant to this Agreement. 

(e) Investment; No Distribution. The Investor is acquiring the Preferred Stock and the Conversion Stock solely for the Investor’s
own account for investment purposes as a principal and not with a view to the resale or distribution of all or any part thereof. The Investor is aware that there may be legal and practical limits on the Investor’s ability to sell or dispose of
the any of the Preferred Stock and the Conversion Stock and, therefore, that the Investor must bear the economic risk of its investment for an indefinite period of time. The Investor acknowledges that it is possible that the Investor may incur a
total loss of its investment. The Investor has adequate means of providing for the Investor’s current needs and possible contingencies and does not have a need for liquidity of this investment. The Investor’s commitment to illiquid
investments, including the investments provided for herein, is reasonable in relation to the Investor’s net worth. 
 (f) No General
Solicitation. The Preferred Stock was not offered to the Investor through, and the Investor is not aware of, any form of general solicitation or general advertising with respect to this Agreement and the transactions contemplated hereby,
including, without limitation: (i) any advertisement, article, notice or other communication published in any newspaper, magazine or similar media or broadcast over television, radio or via the internet, and (ii) any seminar or meeting
whose attendees have been invited by any general solicitation or general advertising. The Investor further understands that the Company is relying in part on this representation to ensure compliance with the Securities Act. 

Section 3.4 Trading Activities. The Investor’s trading activities with respect to the Company’s Common Stock has and
shall be in compliance with all applicable federal and state securities laws, rules and regulations and the rules and regulations of the NYSE. 

Section 3.5 Brokers. No broker or finder has acted for the Investor in connection with this Agreement or the transactions
contemplated thereby, and no broker or finder is entitled to any brokerage or finder’s fees or other commission in respect of such transactions based in any way on agreements, arrangements or understandings made by or on behalf of the Investor.

 Section 3.6 Investment Company. The Investor is not (a) an “investment company” within the meaning of the
Investment Company Act of 1940; or (b) a “holding company” within the meaning of the Public Utility Holding Company Act of 1935. 

  
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 Section 3.7 Legends. The Investor understands that the Preferred Stock and Conversion Stock
may be notated with a legend similar to the following, and/or any legend required by the securities laws of any state to the extent such laws are applicable to the shares represented by the certificate, instrument, or book entry so legended: 

“THE SHARES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO,
OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH TRANSFER MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT
REQUIRED UNDER THE SECURITIES ACT OF 1933.” 
 ARTICLE IV 

REPRESENTATIONS AND WARRANTIES OF THE COMPANY 

Except in each case as provided for in the SEC Documents, the Company hereby represents, warrants and covenants to the Investor as of the date
hereof and each Put Date that: 
 Section 4.1 Existence. The Company: (a) is duly organized, validly existing and in good
standing under the laws of the Commonwealth of Virginia and (b) has the power and authority, and the legal right, to own and operate its property, to lease the property it operates as lessee and to conduct the business in which it is currently
engaged. 
 Section 4.2 Power; Authorization; Enforceable Obligations. The Company: (i) has the power and authority, and
the legal right, to make, deliver and perform this Agreement and to issue the Preferred Stock hereunder, (ii) has taken all necessary action to authorize the execution, delivery and performance of this Agreement. Except as has been disclosed to
the Investor, no consent or authorization of, filing with, notice to or other similar act by or in respect of, any Governmental Authority or any other Person is required to be obtained or made by or on behalf of the Company in connection with the
execution, delivery, performance, validity or enforceability of this Agreement, the issuance of the Preferred Stock or the conversion of the Preferred Stock plus accrued dividends thereon for shares of Conversion Stock on the terms and under the
circumstances provided or herein and in the Articles of Amendment. This Agreement has been duly executed and delivered by the Company. This Agreement constitutes the legal, valid and binding obligation of the Company, enforceable against the Company
in accordance with its terms except as enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium or similar laws affecting creditors’ rights generally and except as enforceability may be subject to general
principles of equity (regardless of whether such enforceability is considered in a proceeding in equity or at law). 
 Section 4.3
No Legal or Contractual Bar. Except as previously disclosed to the Investor, the execution, delivery and performance of this Agreement by the Company, the issuance of the Preferred Stock hereunder and the use of the proceeds thereof by the
Company and the conversion of the Preferred Stock plus accrued and unpaid dividends for shares of Conversion Stock under the circumstances provided for herein: (a) do not and will not violate any Requirement of Law or Contractual Obligation of
the Company or permit the acceleration of any obligation of the Company pursuant to any such Contractual Obligation and (b) do not and 

  
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will not result in, or require, the creation or imposition of any lien or encumbrance on any on the Company’s properties or revenues pursuant to any such Requirement of Law or Contractual
Obligation, except in each case of clauses (a) and (b) as would not reasonably be expected to have a material adverse effect on the business or operations of the Company and its subsidiaries taken as a whole or on the ability
of the Company to timely consummate the transactions contemplated by this Agreement. 
 Section 4.4 Issuance of Shares. Upon
issuance in accordance with this Agreement, the Preferred Stock and the Common Stock issued on conversion thereof will be validly issued, fully paid and non-assessable and free from all taxes, liens and charges with respect to the issuance thereof.

 Section 4.5 SEC Documents; Financial Statements. As of the date hereof, the Company has filed all reports, schedules, forms,
statements and other documents required to be filed by it with the SEC pursuant to the reporting requirements of the Exchange Act that were required to be filed in the prior twelve months. As of their respective filing dates, the SEC Documents
complied in all material respects with the requirements of the Exchange Act and the rules and regulations of the SEC promulgated thereunder applicable to the SEC Documents. 

Section 4.6 Certain Regulations. The Company is not (a) an “investment company,” or a company
“controlled” by an “investment company,” within the meaning of the Investment Company Act of 1940; or (b) a “holding company,” or an “affiliate” of a “holding company” or a “subsidiary
company” of a “holding company,” within the meaning of the Public Utility Holding Company Act of 1935. 
 Section 4.7
Compliance with Laws. The Company has obtained all material approvals required by any Governmental Authority to carry on its business as now being conducted. Each of such approvals is in full force and effect and the Company is in compliance
in all material respects with the terms and conditions of such approvals, and is also in compliance in all material respects with all other provisions of any applicable environmental law. 

Section 4.8 Brokers. No broker or finder has acted for the Company in connection with this Agreement or the transactions
contemplated thereby, and no broker or finder is entitled to any brokerage or finder’s fees or other commission in respect of such transactions based in any way on agreements, arrangements or understandings made by or on behalf of the Company.

 Section 4.9 Acknowledgment Regarding Investor’s Purchase of Preferred Stock. The Company acknowledges and agrees that
the Investor is acting solely in the capacity of an arm’s length purchaser with respect to this Agreement and the transactions contemplated hereby and not as a fiduciary of the Company (or in any similar capacity). The Company further
represents to the Investor that the Company’s decision to enter into this Agreement has been based solely on the independent evaluation by the Company and its representatives. 

  
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 ARTICLE V 

INDEMNIFICATION 

Section 5.1 Indemnification. 

(a) In consideration of the Investor’s execution and delivery of this Agreement, and in addition to all of the Company’s other
obligations under this Agreement, the Company shall defend, protect, indemnify and hold harmless the Investor, and all of its officers, directors, partners, employees and agents (collectively, the “Investor Indemnitees”) from and
against any and all actions, causes of action, suits, claims, losses, costs, penalties, fees, liabilities and damages, and expenses in connection therewith (irrespective of whether any such Investor Indemnitee is a party to the action for which
indemnification hereunder is sought), and including reasonable attorneys’ fees and disbursements (the “Indemnified Liabilities”), incurred by the Investor Indemnitees or any of them to the extent resulting from, or arising out
of, or relating to: (a) any misrepresentation or breach of any representation or warranty made by the Company in this Agreement or any other certificate, instrument or document contemplated hereby or thereby, (b) any breach of any
covenant, agreement or obligation of the Company contained in this Agreement or any other certificate, instrument or document contemplated hereby or thereby, or (c) any cause of action, suit or claim brought or made against such Investor
Indemnitee not arising out of any action or inaction of an Investor Indemnitee, and arising out of or resulting from the execution, delivery, performance or enforcement of this Agreement or any other instrument, document or agreement executed
pursuant hereto by any of the Investor Indemnitees. To the extent that the foregoing undertaking by the Company may be unenforceable for any reason, the Company shall make the maximum contribution to the payment and satisfaction of each of the
Indemnified Liabilities, which is permissible under applicable law. 
 (b) In consideration of the Company’s execution and delivery of
this Agreement, and in addition to all of the Investor’s other obligations under this Agreement, the Investor shall defend, protect, indemnify and hold harmless the Company and all of its officers, directors, shareholders (other than the
Investor), employees and agents (collectively, the “Company Indemnitees”) from and against any and all Indemnified Liabilities incurred by the Company Indemnitees or any of them to the extent resulting from, or arising out of, or
relating to: (a) any misrepresentation or breach of any representation or warranty made by the Investor in this Agreement or any instrument or document contemplated hereby or thereby executed by the Investor, (b) any breach of any
covenant, agreement or obligation of the Investor(s) contained in this Agreement or any other certificate, instrument or document contemplated hereby or thereby executed by the Investor, or (c) any cause of action, suit or claim brought or made
against such Company Indemnitee based on misrepresentations or due to a breach by the Investor and arising out of or resulting from the execution, delivery, performance or enforcement of this Agreement or any other instrument, document or agreement
executed pursuant hereto by any of the Company Indemnitees. To the extent that the foregoing undertaking by the Investor may be unenforceable for any reason, the Investor shall make the maximum contribution to the payment and satisfaction of each of
the Indemnified Liabilities, which is permissible under applicable law. 
 (c) The obligations of the parties to indemnify or make
contribution under this Section 5.1 shall survive termination of this Agreement. 

  
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 ARTICLE VI 

AFFIRMATIVE COVENANTS 

Section 6.1 Maintenance of Properties and Books and Records. The Company hereby covenants and agrees that the Company shall
(a) maintain, preserve, protect and keep its material properties in good repair, working order and condition (ordinary wear and tear excepted), and make reasonable, necessary and proper repairs, renewals and replacements so that its business
carried on in connection therewith may be properly conducted at all times consistent with its past practices, subject to any determinations by the Company with respect to changes in the business, and (b) maintain a standard system of accounting
that enables it timely to produce financial statements in accordance with GAAP. 
 Section 6.2 Maintenance of Insurance. The
Company hereby covenants and agrees that the Company shall maintain insurance with responsible and reputable insurance companies or associations in such amounts and covering such risks as is usually carried by companies of similar size engaged in
similar businesses and owning similar properties in the same general areas in which the Company operates. 
 Section 6.3 Issuance of
the Company’s Preferred Stock. The Company hereby covenants and agrees that, based on and in reliance on the representations and warranties in Section 3 of this Agreement, the sale of the shares of Preferred Stock shall be made in
accordance with the provisions and requirements of Regulation D and any applicable state securities law. 
 Section 6.4 Shareholder
Approval. The Company hereby covenants and agrees that the Company will take all reasonable steps necessary to seek the Shareholder Approval on or before the date of the Company’s annual meeting of shareholders in 2019. 

Section 6.5 Reservation of Shares. The Company hereby covenants and agrees that the Company shall take reasonable steps, including
seeking shareholder approval if necessary, to have authorized and reserved a sufficient number of shares of Common Stock equal to the Conversion Stock issuable upon conversion of all of the outstanding shares of Preferred Stock. 

Section 6.6 Further Action. The Investor hereby covenants and agrees that it and its Affiliates will take all reasonable steps to
support the Company in fulfilling its obligations hereunder, including in connection with authorizing and reserving a sufficient number of shares of Common Stock equal to the Conversion Stock issuable upon conversion of all of the outstanding shares
of Preferred Stock, including voting in favor, and causing its Affiliates to vote in favor of, an amendment to the Articles of Incorporation to increase the authorized capital if the Board of Directors deems it advisable in connection with such
conversion. 
 Section 6.7 Antitrust Approvals. The Investor hereby covenants and agrees that it will promptly notify the
Company of any antitrust approvals that may be required in connection with this Agreement or the Puts. Furthermore, the Investor hereby covenants and agrees that it will promptly seek approval and take such action, to the extent applicable and
required, to permit the Investor to receive shares of Common Stock and to own Common Stock that is receivable upon conversion of the shares of Preferred Stock that it could receive under this Agreement, such that the Investor is not in violation of
applicable law, rule or regulation, including having received such approvals and authorizations of, and made such filings and registrations with, notifications to, or expiration or termination of any applicable waiting period under, the
Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and the rules and regulations thereunder (“HSR Filings”), provided, however, that with respect to any HSR Filing, the Investor shall have complied if such HSR
Filing is made within five Business Days of the date of mailing for Shareholder Approval. 

  
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 ARTICLE VII 

TRANSFER RESTRICTIONS 

Section 7.1 Restrictions on Transfer. The Investor agrees not to Transfer any Preferred Stock except to a Permitted Transferee.

 Section 7.2 Restrictive Legends. Each certificate for the Preferred Stock shall be stamped or otherwise imprinted with a
legend in substantially the following terms: 
 THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE UNITED
STATES SECURITIES ACT OF 1933, AS AMENDED, OR ANY STATE SECURITIES OR BLUE SKY LAWS. THESE SECURITIES MAY NOT BE SOLD OR TRANSFERRED IN THE ABSENCE OF SUCH REGISTRATION OR AN EXEMPTION THEREFROM UNDER SAID ACT OR LAWS. 

ARTICLE VIII 

MISCELLANEOUS 

Section 8.1 Amendments. This Agreement and any terms hereof may not be amended, supplemented or modified except pursuant to a
writing signed by both the Investor and the Company. 
 Section 8.2 Notices. All notices, requests and demands to or upon the
respective parties hereto to be effective shall be in writing (including by facsimile transmission), and, unless otherwise expressly provided herein, shall be deemed to have been duly given or made when delivered: (a) by hand, upon receipt or
(b) three days after being deposited in the mail, postage prepaid, or (c) in the case of a facsimile transmission notice, when received (with confirmation of receipt), or (d) in the case of delivery by a nationally recognized
overnight courier, when received, in each case addressed to such addresses or fax number as may be hereafter notified by the respective parties hereto. 

Section 8.3 No Third-Party Beneficiaries. This Agreement does not create, and shall not be construed as creating, any rights
enforceable by any person or entity not a party hereto. 
 Section 8.4 Waiver. Any waiver or any breach of any of the terms or
conditions of this Agreement shall not operate as a waiver of any other breach of such terms or conditions or of any other term or condition, nor shall any failure to insist upon strict performance or to enforce any provision hereof on any one
occasion operate as a waiver of such provision or of any other provision hereof or a waiver of the right to insist upon strict performance or to enforce such provision or any other provision on any subsequent occasion. Any waiver must be in writing.

 Section 8.5 Successors and Assigns. Neither the Company nor the Investor may assign its rights or obligations under this
Agreement without the consent of the other party. This Agreement shall be binding upon and inure to the benefit of the Company and the Investor and their respective successors and permitted assigns. 

  
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 Section 8.6 Further Assurances. Each party hereto, at the reasonable request of the
other party hereto, shall execute and deliver such other instruments and do and perform such other acts and things as may be necessary or desirable for effecting completely the consummation of this Agreement and the transactions contemplated hereby.

 Section 8.7 Captions. The captions of the Sections and Articles of this Agreement have been inserted for convenience only and
shall have no substantive effect. 
 Section 8.8 Severability. Any provision of this Agreement which is prohibited or
unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective to the extent of such prohibition or unenforceability without invalidating the remaining provisions hereof, and any such prohibition or unenforceability in any
jurisdiction shall not invalidate or render unenforceable such provision in any other jurisdiction. 
 Section 8.9 Governing
Law. This Agreement and any note and the rights and obligations of the parties under this Agreement shall be governed by, and construed and interpreted in accordance with, the internal laws of the Commonwealth of Virginia without regard to any
conflicts of law provisions thereof. 
 Section 8.10 Waiver of Jury Trial. To the extent not prohibited by applicable law which
cannot be waived, each of the Company and the Investor hereby waives, and covenants that it will not assert (whether as plaintiff, defendant or otherwise), any right to trial by jury in any forum in respect of any issue, claim, demand, action, or
cause of action arising out of or based upon this Agreement, the subject matter hereof, any note or the subject matter thereof, in each case whether now existing or hereafter arising and whether in contract or tort or otherwise. Each of the Company
and the Investor acknowledge that it has been informed by the other parties hereto that the provisions of this section constitute a material inducement upon which such other parties have relied, are relying and will rely in entering into this
Agreement. Any party may file an original counterpart or a copy of this section with any court as written evidence of the consent of the Company and the Investor to the waiver of its rights to trial by jury. 

Section 8.11 Counterparts. This Agreement may be executed in any number of counterparts (including by facsimile), each of which
when so executed shall be deemed to be an original and all of which counterparts together shall constitute one and the same instrument. 

[Signature Page Follows] 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed and
delivered on their behalf as of the date first above written. 
  

			
	INVESTOR:
	
	KAPITAL JOE, LLC
	
	By: Third Security, LLC, its Manager
		
	By:	 	 /s/ Randal J. Kirk

	Name:	 	Randal J. Kirk
	Title:	 	Manager
	
	 COMPANY:
  

INTREXON CORPORATION

		
	By:	 	 /s/ Donald P. Lehr

		 	Donald P. Lehr
		 	Chief Legal Officer

 Exhibit A 

ARTICLES OF AMENDMENT 

TO THE 
 AMENDED AND
RESTATED ARTICLES OF INCORPORATION 
 OF 

INTREXON CORPORATION 
 1.
Name of Corporation. The name of the Corporation is Intrexon Corporation. 
 2. Text of Amendments. Article III of the
Corporation’s Amended and Restated Articles of Incorporation (the “Articles of Incorporation”) shall be amended to add Article III.D as set forth in Appendix A attached hereto, stating the terms, including the
preferences, limitations and relative rights, of the Corporation’s Series A Redeemable Preferred Stock (the “Series A Preferred Stock”). 

3. Adoption and Date of Adoption. Pursuant to Section 13.1-639A of the Virginia Stock Corporation Act (the
“Act”), Article III of the Articles of Incorporation permits the Corporation’s Board of Directors to amend the Articles of Incorporation in order to establish the terms, including the preferences, rights and limitations, of one
or more series of the Corporation’s authorized class of preferred stock without the approval of the Corporation’s shareholders. 

The Corporation certifies that the foregoing amendments were adopted on October 16, 2017 by the Corporation’s Board of Directors
without shareholder approval pursuant to the above referenced sections of the Act and Articles of Incorporation. The Corporation has not issued any shares of the Series A Preferred Stock as of the date hereof. 

4. Effective Date and Time. The foregoing amendments to the Articles of Incorporation shall become effective when the Virginia State
Corporation Commission issues the certificate of amendment for such amendments. 
 [Remainder of Page Intentionally Left Blank] 

							
	Dated: [●], 2017	 		 	INTREXON CORPORATION
				
		 		 	            By:	 	  

		 		 		 	Donald P. Lehr
		 		 		 	Chief Legal Officer

 Appendix A 

D. The Corporation is authorized to issue a new series of preferred stock designated as Series A Redeemable Preferred Stock (“the “Series A
Preferred Stock”) as follows: 
 1. Designation and Amount. The shares of such series of Preferred Stock shall be designated
as “Series A Redeemable Preferred Stock” and the number of shares constituting such series shall be 1,000,000 shares. 
 2.
Definitions. For purposes of the Series A Preferred Stock, the following terms shall have the meanings indicated: 

“Affiliate” of any specified Person shall mean any other Person directly or indirectly controlling or controlled by or under
common control with such specified Person. For the purposes of this definition, “control” when used with respect to any specified Person means the power to direct the management and policies of such Person, directly or indirectly, whether
through the ownership of voting securities, by contract or otherwise; and the terms “controlling” and “controlled” have meanings correlative to the foregoing. 

“Board of Directors” or “Board” shall mean the Board of Directors of the Corporation or any committee duly
authorized by such Board of Directors to perform any of its responsibilities with respect to the Series A Preferred Stock. 

“Business Day” shall mean any day other than a Saturday, Sunday or a day on which state or federally chartered banking
institutions in New York, New York are authorized or required to be closed. 
 “Change of Control” shall mean the merger,
consolidation or acquisition of the Corporation with, by or into another Person in which all outstanding shares of Common Stock are converted into or exchanged for cash, securities or other property or assets, other than a new holding company
structure or similar transaction in which the existing stockholders of the Corporation immediately prior to such transaction continue to own greater than 66 2/3% of the equity of the surviving corporation immediately thereafter. 

“Common Stock” shall mean the common stock, no par value per share, of the Corporation or such shares of the
Corporation’s capital stock into which such Common Stock shall be reclassified. 
 “Conversion Calculation Period”
shall mean the period beginning 25 Business Days prior to, and ending on, the fifth Business Day prior to the mailing of the proxy statement soliciting Shareholder Approval for the meeting of the shareholders of the Corporation at which Shareholder
Approval was obtained. 
 “Conversion Price” shall mean, for each share of Series A Preferred Stock, the 20-day
volume-weighted average market price of the Common Stock on the NYSE (or such other national securities exchange or automated quotation system on which the Common Stock is at such time listed or quoted) as of market closing on the fifth Business Day
prior to the mailing of the proxy statement soliciting Shareholder Approval for the meeting of the shareholders of the Corporation at which Shareholder Approval was obtained, subject to adjustment as set forth herein. 

 “Conversion Rate” shall mean, at any time, the Issue Price plus all accrued but
unpaid dividends thereon divided by the Conversion Price. 
 “Deemed Conversion Rate” shall mean, at any time, the Issue
Price plus all accrued but unpaid dividends thereon divided by $18.96, subject to adjustment as set forth herein. 
 “HSR
Approval” shall mean, as to any holder of Series A Preferred Stock, to the extent applicable and required to permit such holder to convert such holder’s shares of Series A Preferred Stock into Common Stock and to own such Common Stock
without such holder being in violation of applicable law, rule or regulation, the receipt of approvals and authorizations of, filings and registrations with, notifications to, or expiration or termination of any applicable waiting period under, the
Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended, and the rules and regulations thereunder. 
 “Issue
Price” shall mean, as to the Series A Preferred Stock, $100 per share (as adjusted equitably with respect to the Conversion Rate for any split, subdivision, combination, consolidation, recapitalization or similar event with respect to the
Series A Preferred Stock). 
 “Mandatory Conversion Date” shall mean, with respect to any share of Series A Preferred
Stock, the fifth Business Day (in the case of clause (i)) or the tenth Business Day (in the case of clause (ii)) following the latest to occur of (i) the receipt by the Corporation of Shareholder Approval, and (ii) if
applicable to the holder, such holder’s receipt of HSR Approval. 
 “NYSE” shall mean the New York Stock Exchange.

 “Person” shall mean any individual, firm, partnership, corporation or other entity and shall include any successor (by
merger or otherwise) of such entity. 
 “Preferred Stock” shall mean the Series A Preferred Stock, and any future series of
capital stock of the Corporation designated as preferred stock. 
 “Set apart for payment” shall be deemed to include,
without any action other than the following, the recording by the Corporation in its accounting ledgers of any accounting or bookkeeping entry which indicates, pursuant to a declaration of dividends or other distribution by the Board of Directors,
the allocation of funds to be paid on any series or class of capital stock of the Corporation; provided, however, that if any funds for any class or series of capital stock of the Corporation ranking junior to the Series A Preferred Stock as
to payment of dividends or distribution of assets upon liquidation, dissolution or winding up of the Corporation are placed in a separate account of the Corporation or delivered to a disbursing, paying or other similar agent, then “set apart
for payment” with respect to the Series A Preferred Stock shall mean placing such funds in a separate account or delivering such funds to a disbursing, paying or other similar agent. 

“Shareholder Approval” shall mean the shareholder approval necessary to approve the conversion of the Preferred Stock into
Common Stock for purposes of Section 312.03 of the New York Stock Exchange Listed Company Manual, which approval shall include a majority of the votes cast by holders of Common Stock other than the votes cast by beneficial holders of Common
Stock who, at such time, are holders of Preferred Stock, or Affiliates of such holders. 

  
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 3. No Maturity, Sinking Fund, Mandatory Redemption. The Series A Preferred Stock has no
stated maturity and will not be subject to any sinking fund, and will remain outstanding indefinitely unless the Corporation decides to redeem or otherwise repurchase the Series A Preferred Stock, the holder exercises its rights to mandatory
redemption, or the Series A Preferred Stock is converted as provided hereunder. The Corporation is not required to set aside funds to redeem the Series A Preferred Stock. 

4. Ranking. The Series A Preferred Stock will rank, (i) with respect to the rights to the payment of dividends, senior to all
classes or series of the Common Stock, and to all other equity securities issued by the Corporation other than equity securities referred to in clause (ii)(A) and (B) of this Section 4, and with respect to the
distribution of assets in the event of any liquidation, dissolution or winding up of the Corporation, on parity to all classes or series of the Common Stock; and (ii) with respect to rights to the payment of dividends and the distribution of
assets in the event of any liquidation, dissolution or winding up of the Corporation, (A) on parity with the Common Stock and all equity securities issued by the Corporation with terms specifically providing that those equity securities rank on
parity with the Series A Preferred Stock with respect to rights to the payment of dividends and the distribution of assets upon any liquidation, dissolution or winding up of the Corporation; (B) junior to all equity securities issued by the
Corporation with terms specifically providing that those equity securities rank senior to the Series A Preferred Stock with respect to rights to the payment of dividends and the distribution of assets upon any liquidation, dissolution or winding up
of the Corporation; and (C) effectively junior to all existing and future indebtedness (including indebtedness convertible into our Common Stock or Preferred Stock) of the Corporation and to any indebtedness and other liabilities of (as well as
any preferred equity interest held by others in) existing subsidiaries of the Corporation. The term “equity securities” shall not include convertible debt securities. 

5. Dividends. 
 (a)
Holders of shares of the Series A Preferred Stock are entitled to receive, out of funds of the Corporation legally available for the payment of dividends, dividends as provided hereinafter. Commencing on the date of issuance of Series A Preferred
Stock (as applicable, the “Issue Date”), cash dividends shall accrue on the Series A Preferred Stock daily, at the rate of 8% per annum on the Issue Price, and shall be cumulative from and including the applicable Issue Date,
and shall be payable to the holders of record of the Series A Preferred Stock as provided hereinafter. Dividends payable on the Series A Preferred Stock will be computed on the basis of a 360-day year consisting of twelve 30-day months. 

(b) No dividends on shares of Series A Preferred Stock shall be authorized by the Board of Directors, or paid or set apart for payment by the
Corporation at any time when the terms and provisions of any agreement of the Corporation, including any agreement relating to any indebtedness of the Corporation, prohibit the authorization, payment or setting apart for payment thereof or provide
that the authorization, payment or setting apart for payment thereof would constitute a breach of the agreement or a default under the agreement, or if the authorization, payment or setting apart for payment shall be restricted or prohibited by law.

  
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 (c) Notwithstanding anything to the contrary contained herein, dividends on the Series A
Preferred Stock will accrue whether or not the Corporation has earnings, whether or not there are funds legally available for the payment of those dividends and whether or not those dividends are declared by the Board of Directors. No interest, or
sum in lieu of interest, will be payable in respect of any dividend payment or payments on the Series A Preferred Stock which may be in arrears, and holders of the Series A Preferred Stock will not be entitled to any dividends in excess of full
cumulative dividends described in Section 5(a). Any dividend payment made on the Series A Preferred Stock shall first be credited against the earliest accumulated but unpaid dividend due with respect to the Series A Preferred Stock. 

(d) Unless full cumulative dividends on the Series A Preferred Stock have been or contemporaneously are declared and paid or declared and a
sum sufficient for the payment thereof has been or contemporaneously is set apart for payment for all past dividend periods, (i) no dividends (other than in shares of Common Stock or in shares of any series of Preferred Stock that the
Corporation may issue ranking junior to the Series A Preferred Stock as to the payment of dividends and the distribution of assets upon liquidation, dissolution, or winding up) shall be declared or paid or set aside for payment upon shares of Common
Stock or Preferred Stock that the Corporation may issue ranking junior to or on a parity with the Series A Preferred Stock as to the payment of dividends, or upon liquidation, dissolution, or winding up, (ii) no other distribution shall be
declared or made upon shares of Common Stock or Preferred Stock that the Corporation may issue ranking junior to or on a parity with the Series A Preferred Stock as to the payment of dividends, or the distribution of assets upon liquidation,
dissolution, or winding up, and (iii) any shares of Common Stock and Preferred Stock that the Corporation may issue ranking junior to, or on a parity with the Series A Preferred Stock as to the payment of dividends, or the distribution of
assets upon liquidation, dissolution, or winding up, shall not be redeemed, purchased or otherwise acquired for any consideration (or any moneys be paid to or made available for a sinking fund for the redemption of any such shares) by the
Corporation (except by conversion into or exchange for other capital stock of the Corporation that it may issue ranking junior to the Series A Preferred Stock as to the payment of dividends, the distribution of assets upon liquidation, dissolution,
or winding up, or in connection with any bona fide equity compensation arrangement). 
 6. Liquidation or Change of Control. 

(a) In the event of any voluntary or involuntary liquidation, dissolution or winding up or Change of Control of the Corporation, the holders of
shares of Series A Preferred Stock shall participate with the holders of the Common Stock, pro rata on an as-converted-to-Common Stock basis, as if converted at the Deemed Conversion Rate, with respect to any payments out of the assets the
Corporation has legally available for distribution to its shareholders, subject to the preferential rights of the holders of any class or series of capital stock of the Corporation it may issue ranking senior to the Series A Preferred Stock with
respect to the distribution of assets upon liquidation, dissolution or winding up. In the event that in connection with a Change of Control, the outstanding shares of Common Stock are converted into or exchanged for cash, securities or other
property or assets, then the holders of Series A Preferred Stock shall be entitled to receive the kind and amount of such cash, securities or other property or assets that such holder would have received had such holder converted such holder’s
shares of Series A Preferred Stock into shares of Common Stock at the Deemed Conversion Rate immediately prior to such Change of Control. 

  
 4 

 (b) For purposes of this Section 6, the shares of Series A Preferred Stock shall be
deemed to have converted into shares of Common Stock at the Deemed Conversion Rate immediately prior to such liquidation, dissolution or winding up or Change of Control of the Corporation. In the event that at any time, the Corporation (i) pays
a stock dividend on one or more classes of its then outstanding shares of Common Stock or otherwise makes a distribution on any class of capital stock that is payable in shares of Common Stock, (ii) subdivides (by any stock split, stock
dividend, recapitalization or otherwise) one or more classes of its then outstanding shares of Common Stock into a larger number of shares, (iii) combines (by combination, reverse stock split or otherwise) one or more classes of its then
outstanding shares of Common Stock into a smaller number of shares, or (iv) distributes or “spins-off” to all holders of Common Stock evidence of indebtedness, shares of capital stock (including capital stock of a subsidiary),
securities or other assets (excluding any dividend or distribution paid exclusively in cash), then in each such case the Deemed Conversion Rate shall be adjusted appropriately to account for such payment, subdivision, combination, distribution or
“spin-off”. 
 (c) Holders of Series A Preferred Stock will be entitled to written notice of any such liquidation, dissolution,
winding up or Change of Control no fewer than 30 days and no more than 60 days prior to the payment date. After payment of the full amount of the liquidating distributions to which they are entitled in this Section 6, the holders of
Series A Preferred Stock will have no right or claim to any of the remaining assets of the Corporation. 
 7. Redemption. 

(a) Optional Redemption Right. The Corporation may, at its option, upon not less than 30 nor more than 60 days’ written notice,
redeem any whole number of shares of Series A Preferred Stock, at any time or from time to time, for cash at a redemption price of the Issue Price per share, plus any accumulated and unpaid dividends thereon to, but not including, the date fixed for
redemption. If the Corporation elects to redeem any shares of Series A Preferred Stock as described in this Section 7(a), it may use any available cash to pay the redemption price, and it will not be required to pay the redemption price
only out of the proceeds from the issuance of other equity securities or any other specific source. 
 (b) Mandatory Redemption
Right. At any time after December 31, 2020, each holder of Series A Preferred Stock may, at its option, upon not less than 60 nor more than 120 days’ written notice, require the Corporation to redeem any whole number of its shares of
Series A Preferred Stock, in whole or in part, for cash at a redemption price of the Issue Price per share, plus any accumulated and unpaid dividends thereon to, but not including, the redemption date. If the Corporation is required to redeem any
shares of Series A Preferred Stock as described in this Section 7(b), it may use any available cash to pay the redemption price, and it will not be required to pay the redemption price only out of the proceeds from the issuance of other
equity securities or any other specific source. 

  
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 (c) In the event the Corporation elects to redeem Series A Preferred Stock, the notice of
redemption will be mailed by the Corporation, postage prepaid, not less than 30 nor more than 60 days prior to the redemption date, to each holder of record of Series A Preferred Stock called for redemption at such holder’s address as it
appears on the stock transfer records of the Corporation and shall state: (i) the redemption date; (ii) the number of shares of Series A Preferred Stock to be redeemed; (iii) the redemption price; (iv) the place or places where
certificates (if any) for the Series A Preferred Stock are to be surrendered for payment of the redemption price; and (v) that dividends on the shares to be redeemed will cease to accumulate on the redemption date. If less than all of the
shares of Series A Preferred Stock held by any holder are to be redeemed, the notice mailed to such holder shall also specify the number of shares of Series A Preferred Stock held by such holder to be redeemed. No failure to give such notice or any
defect thereto or in the mailing thereof shall affect the validity of the proceedings for the redemption of any shares of Series A Preferred Stock except as to the holder to whom notice was defective or not given. 

(d) In the event a holder of Series A Preferred Stock elects to require the Corporation to redeem such holder’s Series A Preferred Stock,
the notice of redemption shall be delivered by such holder to the Corporation at its principal office, not less than 60 nor more than 120 days prior to the redemption date, and shall state: (i) the redemption date; (ii) the number of
shares of Series A Preferred Stock to be redeemed; and (iii) the redemption price and shall include the certificates (if any) for the Series A Preferred Stock to be surrendered for payment of the redemption price. 

(e) Holders of Series A Preferred Stock to be redeemed shall surrender the Series A Preferred Stock at the place designated in the notice of
redemption and shall be entitled to the redemption price and any accumulated and unpaid dividends payable upon the redemption following the surrender. If so required by the Corporation, any certificates surrendered for conversion shall be endorsed
or accompanied by written instrument or instruments of transfer, in form satisfactory to the Corporation, duly executed by the registered holder or by his, her or its attorney duly authorized in writing. 

(f) If notice of redemption of any shares of Series A Preferred Stock has been given and if the Corporation irrevocably sets apart for payment
the funds necessary for redemption in trust for the benefit of the holders of the shares of Series A Preferred Stock so called for redemption, then from and after the redemption date (unless the Corporation shall default in providing for the payment
of the redemption price plus accumulated and unpaid dividends, if any), dividends will cease to accumulate on those shares of Series A Preferred Stock, those shares of Series A Preferred Stock shall no longer be deemed outstanding and all rights of
the holders of those shares will terminate, except the right to receive the redemption price plus accumulated and unpaid dividends, if any, payable upon redemption. 

(g) If any redemption date is not a Business Day, then the redemption price and accumulated and unpaid dividends, if any, payable upon
redemption may be paid on the next Business Day and no interest, additional dividends or other sums will accumulate on the amount payable for the period from and after that redemption date to that next Business Day. 

(h) If less than all of the outstanding Series A Preferred Stock is to be redeemed by the Corporation pursuant to Section 7(a),
the Series A Preferred Stock to be redeemed shall be selected pro rata (as nearly as may be practicable without creating fractional shares) among the holders or by any other equitable method the Corporation shall determine. 

  
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 (i) In connection with any redemption of Series A Preferred Stock, the Corporation shall pay, in
cash, any accrued and unpaid dividends to, but not including, the redemption date. 
 (j) Subject to applicable law, the Corporation may
purchase shares of Series A Preferred Stock directly from an investor, by tender or by any other arrangement. Any shares of Series A Preferred Stock that the Corporation acquires may be retired and re-classified as authorized but unissued shares of
Preferred Stock, without designation as to class or series, and may thereafter be reissued as any class or series of Preferred Stock. 
 8.
Conversion Rights. The shares of Series A Preferred Stock are not convertible into or exchangeable for any other property or securities of the Corporation, except as provided in this Section 8. 

(a) Effective as of the close of business on the Mandatory Conversion Date, all shares of Series A Preferred Stock shall automatically convert
into shares of Common Stock at the Conversion Rate. Such shares of Series A Preferred Stock to be converted into shares of Common Stock on the Mandatory Conversion Date shall be cancelled at the time of the conversion and cease to be issued and
outstanding. 
 (b) The Corporation shall provide notice to holders of Series A Preferred Stock at least 3 Business Days prior to the
Mandatory Conversion Date. In addition to any information required by applicable law or regulation, such notice of mandatory conversion with respect to such shares shall state, as appropriate: 

(i) the applicable Mandatory Conversion Date; 

(ii) the number of shares of Common Stock to be issued upon conversion of each share of Series A Preferred Stock held of record by such holder
and subject to such mandatory conversion; and 
 (iii) if certificates are to be issued, the place or places where certificates for shares
of Series A Preferred Stock held of record by such holder are to be surrendered for issuance of certificates representing shares of Common Stock. 

(c) All rights with respect to the Series A Preferred Stock converted pursuant to this Section 8, including the rights, if any, to
receive notices and vote (other than as a holder of Common Stock), will terminate at the Mandatory Conversion Date (notwithstanding the failure of the holder or holders thereof to surrender any certificates at or prior to such time), except only the
rights of the holders thereof, upon surrender of any certificate or certificates of such holders (or lost certificate affidavit and agreement) therefor, to receive the items provided for in the next sentence of this Subsection 8(c). As soon
as practicable after the Mandatory Conversion Date and, if applicable, the surrender of any certificate or certificates (or lost certificate affidavit and agreement) for Series A Preferred Stock, the Corporation shall (a) issue and deliver to
such holder, or to his, her or its nominees, a certificate or certificates for the number of full shares of Common Stock issuable on such conversion in accordance with the provisions hereof (or, at the

  
 7 

 
Corporation’s option, such shares shall be registered in book-entry form) and (b) pay cash as provided in Subsection 8(e) in lieu of any fraction of a share of Common Stock
otherwise issuable upon such conversion and the payment of any accrued but unpaid dividends on the shares of Series A Preferred Stock converted. 

(d) Any holder of Series A Preferred Stock to be converted following receipt of an HSR Approval shall provide prompt notice to the Corporation
of receipt of such approval (or the expiration of any applicable waiting periods). 
 (e) Upon conversion, holders of Series A Preferred
Stock shall receive cash in lieu of fractional shares. In lieu of any fractional share of Common Stock otherwise issuable in respect of any mandatory conversion pursuant to this Section 8, the Corporation shall pay an amount in cash
(computed to the nearest cent) equal to the same fraction of the closing price of the Common Stock market price of the Common Stock on the NYSE (or such other national securities exchange or automated quotation system on which the Common Stock is at
such time listed or quoted) determined as of the fourth trading day immediately preceding the applicable Mandatory Conversion Date. 
 (f)
The Corporation shall at all times reserve and keep available out of its authorized and unissued Common Stock or shares acquired by the Corporation, solely for issuance upon the conversion of shares of Series A Preferred Stock as provided herein,
free from any preemptive or other similar rights, such number of shares of Common Stock as shall from time to time be issuable upon the conversion of all the shares of Series A Preferred Stock then outstanding. 

(g) All shares of Common Stock delivered upon conversion of the Series A Preferred Stock shall be duly authorized, validly issued, fully paid
and non-assessable, free and clear of all liens, claims, security interests and other encumbrances. 
 (h) Prior to the delivery of any
securities that the Corporation shall be obligated to deliver upon conversion of the Series A Preferred Stock, the Corporation shall use its reasonable best efforts to comply with all federal and state laws and regulations thereunder requiring the
approval of or consent to the delivery thereof by any governmental authority. 
 (i) The Corporation hereby covenants and agrees that, if at
any time the Common Stock shall be listed on the NYSE or any other national securities exchange or automated quotation system, the Corporation shall, if permitted by the rules of such exchange or automated quotation system, list and keep listed, so
long as the Common Stock shall be so listed on such exchange or automated quotation system, all the Common Stock issuable upon conversion of the Series A Preferred Stock. 

(j) The Corporation shall pay any and all stock transfer and documentary stamp taxes that may be payable in respect of any issuance or
delivery of shares of Series A Preferred Stock or shares of Common Stock or other securities issued on account of Series A Preferred Stock pursuant hereto or certificates representing such shares or securities; provided that the Corporation
shall not be required to pay any such tax that may be payable in respect of any transfer involved in the issuance or delivery of shares of Series A Preferred Stock or Common Stock or other securities in a name other than that in which the shares of
Series A Preferred 

  
 8 

 
Stock with respect to which such shares or other securities are issued or delivered were registered, or in respect of any payment to any Person other than a payment to the registered holder
thereof, and shall not be required to make any such issuance, delivery or payment unless and until the Person otherwise entitled to such issuance, delivery or payment has paid to the Corporation the amount of any such tax or has established, to the
satisfaction of the Corporation, that such tax has been paid or is not payable. 
 (k) In the event that at any time after the beginning of
the Conversion Calculation Period and prior to the Mandatory Conversion Date, the Corporation (i) pays a stock dividend on one or more classes of its then outstanding shares of Common Stock or otherwise makes a distribution on any class of
capital stock that is payable in shares of Common Stock, (ii) subdivides (by any stock split, stock dividend, recapitalization or otherwise) one or more classes of its then outstanding shares of Common Stock into a larger number of shares,
(iii) combines (by combination, reverse stock split or otherwise) one or more classes of its then outstanding shares of Common Stock into a smaller number of shares, or (iv) distributes or “spins-off” to all holders of Common
Stock evidence of indebtedness, shares of capital stock (including capital stock of a subsidiary), securities or other assets (excluding any dividend or distribution paid exclusively in cash), then in each such case the Conversion Rate and
Conversion Price shall be adjusted appropriately to account for such payment, subdivision, combination, distribution or “spin-off”. In such circumstance the Corporation shall provide an updated notice of mandatory conversion. 

(l) The Corporation shall seek the Shareholder Approval on or before the date of its annual meeting of shareholders in 2019. 

9. Voting Rights. 
 (a)
Holders of the Series A Preferred Stock will not have any voting rights, except as set forth in this Section 9 or as otherwise required by law. On each matter on which holders of Series A Preferred Stock are entitled to vote, each share
of Series A Preferred Stock will be entitled to one vote, except that when shares of any other class or series of Preferred Stock the Corporation may issue have the right to vote with the Series A Preferred Stock as a single class on any matter, the
Series A Preferred Stock and the shares of each such other class or series will have one vote per share. 
 (b) So long as any shares of
Series A Preferred Stock remain outstanding, the Corporation will not, without the affirmative vote or consent of the holders of at least two-thirds of the shares of the Series A Preferred Stock outstanding at the time, given in person or by proxy,
either in writing or at a meeting (voting together as a class with all other series of parity Preferred Stock that the Corporation may issue upon which like voting rights have been conferred and are exercisable), amend, alter, repeal or replace the
Articles of Incorporation, including by way of merger, consolidation or otherwise in which the Corporation may or may not be the surviving entity, so as to materially and adversely affect and deprive holders of Series A Preferred Stock of any right,
preference or privilege of the Series A Preferred Stock (each, an “Event”). An increase in the amount of the authorized Preferred Stock, including the Series A Preferred Stock, or the creation or issuance of any additional Series A
Preferred Stock or other series of Preferred Stock that the Corporation may issue, or any increase in the amount of 

  
 9 

 
authorized shares of such series, in each case ranking senior to, on a parity with or junior to the Series A Preferred Stock with respect to payment of dividends or the distribution of assets
upon liquidation, dissolution or winding up, shall not be deemed to materially and adversely affect such rights, preferences or privileges. 

(c) Notwithstanding Section 9(b) above, if any Event set forth in Section 9 (b) above materially and adversely
affects any right, preference or privilege of the Series A Preferred Stock but not all series of parity Preferred Stock that the Corporation may issue upon which like voting rights have been conferred and are exercisable, the affirmative vote or
consent of the holders of at least two-thirds of the shares of the Series A Preferred Stock and all such other similarly affected series, outstanding at the time (voting together as a class), given in person or by proxy, either in writing or at a
meeting, shall be required in lieu of the vote or consent that would otherwise be required by Section 9(b). 
 (d) The voting
rights provided for in this Section 9 will not apply if, at or prior to the time when the act with respect to which voting by holders of the Series A Preferred Stock would otherwise be required pursuant to this Section 9
shall be effected, all outstanding shares of Series A Preferred Stock shall have been redeemed or called for redemption upon proper notice and sufficient funds shall have been deposited in trust to effect such redemption pursuant to
Section 7. 
 (e) Except as expressly stated in this Section 9 or as may be required by applicable law, the Series A
Preferred Stock will not have any relative, participating, optional or other special voting rights or powers and the consent of the holders thereof shall not be required for the taking of any corporate action. 

10. No Preemptive Rights. No holders of the Series A Preferred Stock will, as holders of Series A Preferred Stock, have any preemptive
rights to purchase or subscribe for Common Stock or any other security of the Corporation. 
 11. Record Holders. The Corporation and
the transfer agent for the Series A Preferred Stock may deem and treat the record holder of any Series A Preferred Stock as the true and lawful owner thereof for all purposes, and neither the Corporation nor the transfer agent shall be affected by
any notice to the contrary. 

  
 10Exhibit 10.1

 

SECOND AMENDMENT TO LEASE

 

THIS SECOND AMENDMENT TO LEASE (this “Amendment”) dated as of this 10th day of October, 2017 (the “Effective Date”), is entered into by and between CCC INVESTORS LLC, a Delaware limited liability company (“Landlord”), and OCULAR THERAPEUTIX, INC., a Delaware corporation (f/k/a I-Therapeutix, Inc.) (“Tenant”), relating to the premises located in the building (the “Building”) located in the Town of Bedford, County of Middlesex, Commonwealth of Massachusetts, commonly known as 36 Crosby Drive (the “Property”).

 

WITNESSETH:

 

WHEREAS, Landlord’s predecessor-in-interest, RAR2-Crosby Corporate Center QRS, Inc., a Maryland corporation (“Original Landlord”), as landlord, and Tenant, as tenant, entered into that certain Lease bearing a Lease Reference Date of August 31, 2009, with respect to approximately 19,786 rentable square feet located on the first (1st) floor of the Building (the “Original Lease”), as affected by the (a) Commencement Date Memorandum dated as of December 29, 2009, by and between Original Landlord, as landlord, and Tenant, as tenant, and (b) First Amendment to Lease dated as of April 25, 2014, by and between Original Landlord, as landlord, and Tenant, as tenant (the “First Amendment”) (the Original Lease, as so affected, collectively, the “Lease”);

 

WHEREAS, Landlord, as the successor-in-interest to Original Landlord, is the current owner of the Property and the current holder of the landlord’s interest under the Lease and Tenant, as a result of a name change from I-Therapeutix, Inc. to Ocular Therapeutix, Inc., is the current holder of the tenant’s interest under the Lease; and

 

WHEREAS, Landlord and Tenant desire to amend the Lease to, among other things, (i) confirm the current rentable square footage of the Premises (as defined in the Lease), and (ii) extend the Term of the Lease (as defined in the Lease) through July 31, 2023, all as more fully set forth below.

 

NOW, THEREFORE, in consideration of the mutual covenants and conditions contained herein and other good and valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the parties agree as follows:

 

Agreements

 

1.                                      Capitalized Terms.  Unless otherwise specifically set forth herein, all capitalized terms herein shall have the same meaning as set forth in the Lease.

 

2.                                      Recitals.  The recitals above set forth are true and complete and are incorporated herein by reference.

 

 

3.                                      34 Crosby Premises.  Landlord and Tenant hereby acknowledge and agree that (a) pursuant to the terms and provisions of the Original Lease (as amended by the First Amendment), the 34 Crosby Premises Termination Date has occurred and Tenant has vacated and surrendered the 34 Crosby Premises in accordance with the terms and provisions of the Original Lease (as amended by the First Amendment), (b) Landlord no longer leases to Tenant, and Tenant no longer leases from Landlord, the 34 Crosby Premises, and (c) effective as of the 34 Crosby Premises Termination Date, the terms and provisions of the Lease no longer apply to the 34 Crosby Premises.

 

4.                                      Premises Rentable Area.  Landlord and Tenant hereby acknowledge and agree that, effective as of July 1, 2018, and as a result of a remeasurement of the Premises, the Premises Rentable Area is 20,445 rentable square feet, as more particularly set forth in Schedule I attached hereto.

 

5.                                      Amendments.  Except as otherwise expressly set forth hereinbelow, as of the Effective Date, the Lease is hereby amended as follows:

 

a.                                      Reference Pages.  The Reference Pages set forth on pages iii through vi of the Original Lease are hereby amended, restated and superseded in their entirety as set forth on Schedule I attached hereto.

 

b.                                      Premises.  The introductory paragraph of the Original Lease is hereby amended by deleting the second (2nd) sentence thereof in its entirety and replacing it with the following:

 

“The Phase I Premises and the Phase II Premises are depicted on the floor plan attached hereto as Exhibit A.”

 

c.                                       Use of the Premises.  Section 1.1 of the Lease is hereby amended by deleting the second (2nd) to the last sentence thereof in its entirety and replacing it with the following:

 

“Notwithstanding the foregoing, following the Commencement Date with respect to the Phase I Premises and following the Phase II Premises Commencement Date with respect to the Phase II Premises, Tenant shall be responsible for ensuring that (a) Tenant’s layout of its personal property, including without limitation, partitions, cubicles and equipment, but excluding the Landlord’s Work, and (b) any alterations to the Phase I Premises and the Phase II Premises, respectively, comply with the Americans With Disabilities Act of 1990, and any amendments thereto, at Tenant’s sole cost and expense.”

 

d.                                      Term.  Section 2.1 of the Original Lease is hereby amended by deleting the first (1st) sentence thereof in its entirety and replacing it with the following:

 

A-1

 

“The Term of this Lease shall begin on the Commencement Date and shall terminate on the Termination Date, unless sooner terminated or extended pursuant to the terms and provisions of this Lease.”

 

e.                                       Expenses.  Section 4.1.2 of the Original Lease is hereby amended by deleting the words “For each of the 34 Crosby Building and the 36 Crosby Building” from the first (1st) sentence thereof .

 

f.                                        Base Years.  Section 4.2 of the Lease is hereby amended to read in its entirety as follows:

 

“4.2                         If in any Lease Year, Expenses paid or incurred shall exceed Expenses paid or incurred in the Base Year (Expenses), then Tenant shall pay, as additional rent for such Lease Year, Tenant’s Proportionate Share For Expenses of such excess.  If in any Lease Year, Taxes paid or incurred by Landlord in any Lease Year shall exceed the amount of such Taxes which become due and payable in the Base Year (Taxes), then Tenant shall pay as additional rent for such Lease Year, Tenant’s Proportionate Share For Taxes of such excess.”

 

g.                                       Audit Rights.  Section 4.3 of the Lease is hereby amended by deleting the last three (3) sentences thereof in their entirety and replacing them with the following:

 

“If, as a result of such audit, it becomes clear that an error was made in the calculation of the Expenses or of Tenant’s Proportionate Share For Expenses, then an appropriate adjustment shall be made within thirty (30) days of Landlord’s receipt from Tenant of a copy of such audit together with Tenant’s demand for reimbursement and, if Landlord has understated Base Year (Expenses) or overstated any subsequent years’ Expenses by more than five percent (5%), in each respective case in the aggregate, or if the amount by which Landlord over-charged Tenant exceeds five percent (5%) of Tenant’s Proportionate Share For Expenses in the aggregate, then Landlord shall pay the reasonable actual out-of-pocket costs and expenses paid by Tenant for the audit.  In the event that during all or any portion of any Lease Year or Base Year (Expenses), the Building is not fully rented and occupied Landlord shall make an appropriate adjustment in occupancy-related Expenses for such year for the purpose of avoiding distortion of the amount of such Expenses to be attributed to Tenant by reason of variation in total occupancy of the Building, by employing consistent and sound accounting and management principles to determine Expenses that would have been paid or incurred by Landlord had the Building been at least ninety-five percent (95%) rented and occupied, and the amount so determined shall be deemed to have been Expenses for such Lease Year.  Following its annual determination of Expenses pursuant to this Article 4, in no event shall Landlord recover from Tenant more than

 

A-2

 

Tenant’s Proportionate Share For Expenses of the actual Expenses paid or incurred by Landlord.”

 

h.                                      Expenses and Taxes.  Section 4.5.2 of the Lease is hereby amended by deleting the last sentence thereof in its entirety and replacing it with the following:

 

“Tenant shall not be entitled to a credit by reason of actual Expenses and/or Taxes in any Lease Year being less than Expenses and/or Taxes in the Base Year (Expenses and/or Taxes).”

 

i.                                          Holding Over.  Article 14 of the Lease is hereby amended to read in its entirety as follows:

 

“14.                         HOLDING OVER.  Tenant shall pay Landlord for each day Tenant retains possession of the Premises or part of them after the Termination Date or earlier termination of this Lease, by lapse of time or otherwise, at the rate (the “Holdover Rate”) which shall be One Hundred Fifty Percent (150%) of the greater of the (a) amount of the Annual Rent in effect for the Premises for the last period prior to the date of such termination plus all Rent Adjustments under Article 4; and (b) then market rental value of the Premises as determined by Landlord assuming a new lease of the Premises of the then usual duration and other terms, prorated on a daily basis, and also pay all damages sustained by Landlord by reason of such retention.  In the event of such holdover, a tenancy at sufferance at the Holdover Rate shall be deemed to have been created.  In any event, no provision of this Article 14 shall be deemed to waive Landlord’s right of reentry or any other right under this Lease or at law.”

 

j.                                         Events of Default.  Section 18.1.3 of the Lease is hereby amended to read in its entirety as follows:

 

“18.1.3        Tenant shall fail to vacate the Premises immediately upon the Termination Date or immediately upon the earlier termination of this Lease, by lapse of time or otherwise, or upon termination of Tenant’s right to possession only.”

 

k.                                      Casualty.  Section 22.1 of the Lease is hereby amended by:  (a) deleting the words “that either the 34 Crosby Premises, the 36 Crosby Premises, the 34 Crosby Building and/or the 36 Crosby Building, as applicable,” from the first (1st) sentence thereof and replacing them with the words “the Premises or the Building”; and (b) deleting the words “34 Crosby Premises and/or the 36 Crosby Premises, as applicable,” from the second (2nd) sentence thereof and replacing them with the word “Premises”.

 

A-3

 

Section 22.2 of the Lease is hereby amended by deleting the first (1st) and second (2nd) sentences thereof and replacing them with the following:

 

“If such repairs cannot, in Landlord’s reasonable estimation, be made within one hundred eighty (180) days, Landlord and Tenant shall each have the option of giving the other, at any time within ninety (90) days after such damage, notice terminating this Lease as of the date of such damage.  In the event of the giving of such notice, this Lease shall expire and all interest of Tenant in the Premises shall terminate as of the date of such damage as if such date had been originally fixed in this Lease for the expiration of the Term.”

 

Section 22.4 of the Lease is hereby amended by:  (a) deleting the words “with respect to the portion of the Premises in the damaged Building only” and the words “with respect to the portion of the Premises in the damaged Building only” therefrom.

 

Section 22.5 of the Lease is hereby amended by deleting the words “with respect to the portion of the Premises in the damaged Building only” therefrom.

 

l.                                          Eminent Domain.  Article 23 of the Lease is hereby amended to read in its entirety as follows:

 

“23.                         EMINENT DOMAIN.  If all or any substantial part of the Premises shall be taken or appropriated by any public or quasi-public authority under the power of eminent domain, or conveyance in lieu of such appropriation, either party to this Lease shall have the right, at its option, of giving the other, at any time within thirty (30) days after such taking, notice terminating this Lease, except that Tenant may only terminate this Lease by reason of taking or appropriation, if such taking or appropriation shall be so substantial as to materially interfere with Tenant’s use and occupancy of the Premises.  If neither party to this Lease shall so elect to terminate this Lease, the rental thereafter to be paid shall be adjusted on a fair and equitable basis under the circumstances.  In addition to the rights of Landlord above, if any substantial part of the Building shall be taken or appropriated by any public or quasi-public authority under the power of eminent domain or conveyance in lieu thereof, and regardless of whether the Premises or any part thereof are so taken or appropriated, Landlord shall have the right, at its sole option, to terminate this Lease.  Landlord shall be entitled to any and all income, rent, award, or any interest whatsoever in or upon any such sum, which may be paid or made in connection with any such public or quasi-public use or purpose, and Tenant hereby assigns to Landlord any interest it may have in or claim to all or any part of such sums, other than any separate award which may be made with respect to Tenant’s trade fixtures and

 

A-4

 

moving expenses.  Tenant shall make no claim for the value of any unexpired Term.”

 

m.                                  Sale By Landlord.  Article 24 of the Lease is hereby amended by deleting the first (1st) sentence thereof in its entirety and replacing it with the following:

 

“In event of a sale or conveyance by Landlord of the Building, the same shall operate to release Landlord from any future liability upon any of the covenants or conditions, expressed or implied, contained in this Lease in favor of Tenant, and in such event Tenant agrees to look solely to the responsibility of the successor in interest of Landlord in and to this Lease.”

 

n.                                      Surrender of Premises.  Section 26.1 of the Lease is hereby amended to read in its entirety as follows:

 

“26.1                  Tenant shall arrange to meet Landlord for two (2) joint inspections of the Premises, the first to occur at least thirty (30) days (but no more than sixty (60) days) before the last day of the Term, and the second to occur not later than forty-eight (48) hours after Tenant has vacated the Premises.  In the event of Tenant’s failure to arrange such joint inspections and/or participate in either such inspection, Landlord’s inspection at or after Tenant’s vacating the Premises shall be conclusively deemed correct for purposes of determining Tenant’s responsibility for repairs and restoration.”

 

o.                                      Right of First Offer.  Article 41 of the Lease is hereby deleted in its entirety and, as a result, Tenant has no further rights thereunder.

 

p.                                      Termination Option.  The Lease is hereby amended by adding the following as Article 43 thereof:

 

“43.                         TERMINATION OPTION.  Subject to the conditions set forth hereinbelow, Tenant shall have the one-time right to terminate this Lease (the “Termination Option”) on July 31, 2021 (the “Early Termination Date”), provided Tenant notifies Landlord, in writing, of Tenant’s intention to terminate this Lease on or before July 31, 2020 (the “Termination Notice”) time being of the essence with respect thereto.  In connection with its exercise of the Termination Option, Tenant shall pay to Landlord, simultaneously with Tenant’s delivery of the Termination Notice to Landlord, the sum of Two Hundred Seventy-Three Thousand Four Hundred Seventy-Three and 96/100 Dollars ($273,473.96) (the “Termination Fee”), which Termination Fee consists of (a) four (4) months’ Annual Rent as of the Early Termination Date (which totals One Hundred Ninety-One Thousand Five Hundred Sixty-Nine and 65/100 Dollars ($191,569.65)), plus (b) the unamortized portion of Landlord’s transaction costs for attorneys’ fees and brokerage fees with respect to the

 

A-5

 

Second Amendment as of the Early Termination Date (which transaction costs total One Hundred Seventy-Six Thousand Seven Hundred Sixty-Two and 50/100 Dollars ($176,762.50) as of the Effective Date of the Second Amendment), based upon an interest factor equal to the Amortization Rate per annum for such amortization calculation, which unamortized amount Landlord and Tenant hereby agree totals Eighty-One Thousand Nine Hundred Four and 31/100 Dollars ($81,904.31) as of the Early Termination Date.  If Tenant fails to (i) timely exercise the Termination Option in accordance with the terms and provisions of this Article 43, or (ii) deliver to Landlord the Termination Fee simultaneously with the delivery of Tenant’s Termination Notice to Landlord, the Termination Option and this Article 43 shall be null and void and without further force and effect.  Tenant’s right to terminate this Lease as set forth herein is conditioned upon (A) there being no ongoing Event of Default on the date the Termination Notice is delivered to Landlord, (B) this Lease being in full force and effect on the date the Termination Notice is delivered to Landlord and on the day immediately preceding the Early Termination Date, and (C) Landlord having received the Termination Fee when required as aforesaid.  Should Tenant effectively exercise its Termination Option as set forth herein, (x) the Term of this Lease shall automatically terminate on the Early Termination Date, with all of the terms and conditions of this Lease, including, without limitation, the obligation to pay Annual Rent, additional rent, utilities and other changes hereunder remaining in full force and effect until the Early Termination Date, and (y) Tenant shall relinquish, yield up and surrender the Premises on the Early Termination Date in accordance with the provisions of this Lease.”

 

q.                                      Exhibits.  As of the Effective Date, (i) Exhibit A (Floor Plan Depicting Premises) to the Lease is hereby amended by deleting the second (2nd) page of the floor plan therefrom, which shows the 34 Crosby Premises and was added to the Lease pursuant to Section 3(s) of the First Amendment, and (ii) Exhibit E (Right of First Offer Space) to the Lease is hereby deleted in its entirety.

 

6.                                      Security Deposit.  Effective and conditioned upon Landlord’s receipt of a replacement letter of credit in the amount of $113,769.49 and meeting the requirements of Article 5 of the Lease (a “Replacement Letter of Credit”), the parties agree to reduce the amount of the Security Deposit to $113,769.49.  Subject to the foregoing conditions and the terms and provisions of Article 5 of the Lease (including, without limitation, Section 5.10 of the Lease), simultaneously with Landlord’s receipt of the Replacement Letter of Credit, Landlord shall return the original letter of credit that Landlord is currently holding in the amount of $227,539.00 to Tenant.

 

7.                                      Condition of Premises.  Tenant hereby acknowledges and agrees that (a) the Premises are being leased by Tenant in their condition as of the Effective Date, “As Is,” without representation or warranty by Landlord, and (b) Tenant is the

 

A-6

 

current tenant of the Premises and, as of the Effective Date, it has inspected the Premises and the common facilities of the Building and has found the same to be satisfactory.

 

8.                                      Miscellaneous.  Tenant hereby acknowledges that (a) Landlord has no undischarged obligations under the Lease to perform any work or improvements to the Premises or to provide any tenant improvement allowance under the Lease, (b) there are no offsets or defenses that Tenant has against the full enforcement of the Lease by Landlord, (c) neither Landlord nor Tenant is in any respect in default under the Lease, and (d) Tenant has not assigned, transferred or hypothecated the Lease or any interest therein or subleased all or any portion of the Premises.

 

9.                                      Brokers.  Landlord and Tenant hereby represent and warrant to each other that neither has dealt with any real estate broker or agent in connection with the procurement of this Amendment except Newmark Grubb Knight Frank and Cushman & Wakefield of Massachusetts, Inc., whose commissions shall be paid by Landlord by separate agreement upon the completion and full execution of this Amendment, and not otherwise.  Tenant shall indemnify and hold Landlord harmless from any costs, expense or liability (including costs of suit and reasonable attorneys’ fees) for any compensation, commission or fees claimed by any real estate broker or agent other than the aforementioned brokers in connection with the procurement of this Amendment because of any act or statement by Tenant.  Landlord shall indemnify and hold Tenant harmless from any costs, expense or liability (including costs of suit and reasonable attorneys’ fees) for any compensation, commission or fees claimed by any real estate broker or agent other than the aforementioned brokers in connection with the procurement of this Amendment because of any act or statement by Landlord.

 

10.                               Effective Date.  The parties agree that this Amendment shall be effective from and after the Effective Date and not to any period of time prior thereto.  To the extent this Amendment contains language which purports to amend the Lease with respect to periods of time prior to the Effective Date, such language is for clarification purposes only and shall not be deemed to change the obligations of the parties with respect thereto.  In no event shall this Amendment be construed to impose any liability on Landlord for any period of time preceding its ownership of the Property.

 

11.                               Options to Extend.  Tenant has one (1) remaining option to extend the Term of Lease with respect to the Premises pursuant to the terms and provisions of Article 40 of the Lease.

 

12.                               Ratification of Lease Provisions.  Except as otherwise expressly amended, modified and provided for in this Amendment, Tenant hereby ratifies all of the provisions, covenants and conditions of the Lease, and such provisions, covenants and conditions shall be deemed to be incorporated herein and made a part hereof and shall continue in full force and effect.

 

A-7

 

13.                               Entire Amendment.  This Amendment contains all the agreements of the parties with respect to the subject matter hereof and supersedes all prior dealings between the parties with respect to such subject matter.

 

14.                               Binding Amendment.  This Amendment shall be binding upon, and shall inure to the benefit of the parties hereto, and their respective successors and assigns.

 

15.                               Landlord’s Liability.  Redress for any claims against Landlord under this Amendment or under the Lease shall only be made against Landlord to the extent of Landlord’s interest in the Property to which the Premises are a part.  The obligations of Landlord under this Amendment and the Lease shall not be personally binding on, nor shall any resort be had to the private properties of, any of its trustees or board of directors and officers, as the case may be, the general partners thereof or any beneficiaries, stockholders, employees or agents of Landlord, or its investment manager.

 

16.                               Governing Law.  This Amendment shall be governed by the law of the state in which the Property is located.

 

17.                               Authority.  Landlord and Tenant each warrant to the other that the person or persons executing this Amendment on its behalf has or have authority to do so and that such execution has fully obligated and bound such party to all terms and provisions of this Amendment.

 

18.                               Severability.  If any clause or provision of this Amendment is or should ever be held to be illegal, invalid or unenforceable under any present or future law applicable to the terms hereof, then and in that event, it is the intention of the parties hereto that the remainder of this Amendment shall not be affected thereby, and that in lieu of each such clause or provision of this Amendment that is illegal, invalid or unenforceable, such clause or provision shall be judicially construed and interpreted to be as similar in substance and content to such illegal, invalid or unenforceable clause or provision, as the context thereof would reasonably suggest, so as to thereafter be legal, valid and enforceable.

 

19.                               No Reservation.  Submission of this Amendment for examination or signature is without prejudice and does not constitute a reservation, option or offer, and this Amendment shall not be effective until execution and delivery by all parties.

 

20.                               Counterparts.  This Amendment may be executed simultaneously in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.

 

[SIGNATURES ON FOLLOWING PAGE]

 

A-8

 

IN WITNESS WHEREOF, Landlord and Tenant have executed the Amendment as of the day and year first written above.

 

	
 
    	
LANDLORD:
    
	
 
    	
 
    
	
 
    	
CCC INVESTORS LLC, a   Delaware limited liability company
    
	
 
    	
 
    
	
 
    	
 
    
	
 
    	
By:
    	
/s/ Stephen A. Kinsella
    
	
 
    	
Name:
    	
Stephen A. Kinsella
    
	
 
    	
Title:
    	
Authorized Officer
    
	
 
    	
 
    
	
 
    	
 
    
	
 
    	
TENANT:
    
	
 
    	
 
    
	
 
    	
OCULAR   THERAPEUTIX, INC., a Delaware corporation
    
	
 
    	
 
    
	
 
    	
 
    
	
 
    	
By: 
    	
/s/ James Fortune
    
	
 
    	
Name: 
    	
James Fortune
    
	
 
    	
Title: 
    	
Chief Operating Officer
    

 

A-9

 

Schedule I

 

OFFICE LEASE

 

REFERENCE PAGES

 

	
BUILDING:
    	
 
    	
36 Crosby Drive
   Bedford, Massachusetts 01730
    
	
 
    	
 
    	
 
    
	
LANDLORD:
    	
 
    	
CCC Investors LLC, a Delaware limited liability   company
    
	
 
    	
 
    	
 
    
	
LANDLORD’S ADDRESS:
    	
 
    	
CCC Investors LLC
   c/o National Development
   2310 Washington Street
   Newton Lower Falls, Massachusetts 02642
   Attn: Director of Asset Management
    
   With copies of any notices to Landlord sent to:
    
   National Development
   2310 Washington Street
   Newton Lower Falls, Massachusetts 02642
   Attn: Richard P. Schwartz, Esq.
    
	
 
    	
 
    	
 
    
	
WIRE INSTRUCTIONS AND/OR ADDRESS
   FOR RENT PAYMENT:
    	
 
    	
CCC Investors LLC
   c/o National Development
   P.O. Box 847072
   Boston, MA 02284-7072
    
	
 
    	
 
    	
 
    
	
LEASE REFERENCE DATE:
    	
 
    	
August 31, 2009
    
	
 
    	
 
    	
 
    
	
TENANT:
    	
 
    	
OCULAR THERAPEUTIX, INC., a Delaware   corporation
    
	
 
    	
 
    	
 
    
	
TENANT’S NOTICE ADDRESS:
    	
 
    	
Attn: Jim Fortune
   15 Crosby Drive
   Bedford, Massachusetts 01730
    
	
 
    	
 
    	
 
    
	
PREMISES ADDRESSES:
    	
 
    	
36 Crosby Drive
   Suite 101
   Bedford, Massachusetts 01730
    
	
 
    	
 
    	
 
    
	
PREMISES RENTABLE AREA:
    	
 
    	
From the Commencement Date through the day   immediately preceding the Phase II Premises Commencement Date, the “Premises   Rentable Area” shall consist of approximately 10,147 rentable square feet   located on the first (1st) floor of the Building as shown on Exhibit A (the “Phase I   Premises”).

From the Phase II Premises Commencement Date through   June 30, 2018, the “Premises Rentable Area” shall consist of   approximately 19,786 rentable square feet in the aggregate located on the   first (1st)   floor of the Building as shown on Exhibit A,   consisting of (i) the Phase I Premises, and (ii) approximately   9,639 rentable square feet (the “Phase II Premises”).

From July 1, 2018 through the Termination Date,   the “Premises Rentable Area” shall consist of approximately 20,445 rentable   square 
    

 

S-1

 

	
 
    	
 
    	
feet in the aggregate located on the first (1st) floor of the Building as   shown on Exhibit A, consisting   of the Phase I Premises and the Phase II Premises, subject to the terms and   provisions of Section 4 of the Second Amendment to this Lease by and   between Landlord and Tenant (the “Second Amendment”).
    
	
 
    	
 
    	
 
    
	
PREMISES:
    	
 
    	
From the Commencement Date through the day   immediately preceding the Phase II Premises Commencement Date, the “Premises”   shall consist of the Phase I Premises.
    
   From the Phase II Premises Commencement Date through the Termination Date,   the “Premises” shall consist of the Phase I Premises and the Phase II   Premises.
    
	
 
    	
 
    	
 
    
	
PREMISES:
    	
 
    	
Together, the Phase I Premises and the Phase II   Premises.
    
	
 
    	
 
    	
 
    
	
COMMENCEMENT DATE:
    	
 
    	
September 15, 2009.
    
	
 
    	
 
    	
 
    
	
PHASE I PREMISES COMMENCEMENT DATE:
    	
 
    	
September 15, 2009.
    
	
 
    	
 
    	
 
    
	
PHASE II PREMISES COMMENCEMENT DATE:
    	
 
    	
December 15, 2009.
    
	
 
    	
 
    	
 
    
	
PHASE I PREMISES RENT COMMENCEMENT DATE:
    	
 
    	
The Commencement Date.
    
	
 
    	
 
    	
 
    
	
PHASE II PREMISES RENT COMMENCEMENT DATE:
    	
 
    	
April 15, 2010.
    
	
 
    	
 
    	
 
    
	
TERM OF LEASE:
    	
 
    	
Approximately thirteen (13) years, ten   (10) months, sixteen (16) days, beginning on the Commencement Date and   ending on the Termination Date.
    
	
 
    	
 
    	
 
    
	
TERMINATION DATE:
    	
 
    	
July 31, 2023.
    

 

S-2

 

ANNUAL RENT and MONTHLY 

INSTALLMENT OF RENT(Article 3):

 

	
Period
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
From
    	
 
    	
Through
    	
 
    	
Rentable
   Square
   Footage
    	
 
    	
Annual Rent
   Per Square
   Foot
    	
 
    	
Annual Rent
    	
 
    	
Monthly Installment of
   Rent
    	
 
    
	
Commencement   Date
    	
 
    	
December 14, 2009
    	
 
    	
10,147
    	
 
    	
$
    	
21.75
    	
 
    	
$
    	
220,697.25
    	
 
    	
$
    	
18,391.44
    	
 
    
	
December 15,   2009
    	
 
    	
April 14, 2010
    	
 
    	
19,786
    	
 
    	
$
    	
0.00
    	
*
    	
$
    	
0.00
    	
*
    	
$
    	
0.00
    	
*
    
	
April 15,   2010
    	
 
    	
December 31, 2010
    	
 
    	
19,786
    	
 
    	
$
    	
22.25
    	
 
    	
$
    	
440,238.50
    	
 
    	
$
    	
36,686.54
    	
 
    
	
January 1,   2011
    	
 
    	
December 31, 2011
    	
 
    	
19,786
    	
 
    	
$
    	
22.75
    	
 
    	
$
    	
450,131.50
    	
 
    	
$
    	
37,510.96
    	
 
    
	
January 1,   2012
    	
 
    	
December 31, 2012
    	
 
    	
19,786
    	
 
    	
$
    	
23.25
    	
 
    	
$
    	
460,024.50
    	
 
    	
$
    	
38,335.38
    	
 
    
	
January 1,   2013
    	
 
    	
December 31, 2013
    	
 
    	
19,786
    	
 
    	
$
    	
23.75
    	
 
    	
$
    	
469,917.50
    	
 
    	
$
    	
39,159.79
    	
 
    
	
January 1,   2014
    	
 
    	
December 31, 2014
    	
 
    	
19,786
    	
 
    	
$
    	
24.25
    	
 
    	
$
    	
479,810.50
    	
 
    	
$
    	
39,984.21
    	
 
    
	
January 1,   2015
    	
 
    	
June 30, 2015
    	
 
    	
19,786
    	
 
    	
$
    	
24.75
    	
 
    	
$
    	
489,703.50
    	
 
    	
$
    	
40,808.63
    	
 
    
	
July 1,   2015
    	
 
    	
June 30, 2016
    	
 
    	
19,786
    	
 
    	
$
    	
25.50
    	
 
    	
$
    	
504,543.00
    	
 
    	
$
    	
42,045.25
    	
 
    
	
July 1,   2016
    	
 
    	
June 30, 2017
    	
 
    	
19,786
    	
 
    	
$
    	
26.00
    	
 
    	
$
    	
514,436.00
    	
 
    	
$
    	
42,869.67
    	
 
    
	
July 1,   2017
    	
 
    	
June 30, 2018
    	
 
    	
19,786
    	
 
    	
$
    	
26.50
    	
 
    	
$
    	
524,329.00
    	
 
    	
$
    	
43,694.08
    	
 
    
	
July 1,   2018
    	
 
    	
July 31, 2018
    	
 
    	
20,445
    	
 
    	
$
    	
0.00
    	
*
    	
$
    	
0.00
    	
*
    	
$
    	
0.00
    	
*
    
	
August 1,   2018
    	
 
    	
July 31, 2019
    	
 
    	
20,445
    	
 
    	
$
    	
26.61
    	
 
    	
$
    	
544,041.45
    	
 
    	
$
    	
45,336.79
    	
 
    
	
August 1,   2019
    	
 
    	
July 31, 2020
    	
 
    	
20,445
    	
 
    	
$
    	
27.36
    	
 
    	
$
    	
559,375.20
    	
 
    	
$
    	
46,614.60
    	
 
    
	
August 1,   2020
    	
 
    	
July 31, 2021
    	
 
    	
20,445
    	
 
    	
$
    	
28.11
    	
 
    	
$
    	
574,708.95
    	
 
    	
$
    	
47,892.41
    	
 
    
	
August 1,   2021
    	
 
    	
July 31, 2022
    	
 
    	
20,445
    	
 
    	
$
    	
28.86
    	
 
    	
$
    	
590,042.70
    	
 
    	
$
    	
49,170.23
    	
 
    
	
August 1,   2022
    	
 
    	
July 31, 2023
    	
 
    	
20,445
    	
 
    	
$
    	
29.61
    	
 
    	
$
    	
605,376.45
    	
 
    	
$
    	
50,448.04
    	
 
    

 

*Tenant shall only be entitled to this abatement of Annual Rent during these periods if no Event of Default exists, and notwithstanding anything to the contrary set forth above, Tenant shall pay for its electricity, utilities and Additional Rent (if any) for the Premises during these periods in accordance with the terms and provisions of this Lease.

 

	
BASE YEAR (EXPENSES):
    	
 
    	
From the Commencement Date through June 30,   2015, Calendar Year 2010.
    
   From July 1, 2015 through June 30, 2018, Calendar Year 2015.
    
   From July 1, 2018 through the Termination Date, Calendar Year 2018.
    

 

S-3

 

	
BASE YEAR (TAXES):
    	
 
    	
From the Commencement Date through June 30,   2015, Fiscal Year 2010.
    
   From July 1, 2015 through June 30, 2018, Fiscal Year 2016.
    
   From July 1, 2018 through the Termination Date, Fiscal Year 2019.
    
	
 
    	
 
    	
 
    
	
TENANT’S PROPORTIONATE SHARE FOR EXPENSES:
    	
 
    	
From the Commencement Date through the day   immediately preceding the Phase II Premises Commencement Date, “Tenant’s   Proportionate Share For Expenses” shall be thirteen and 06/100 percent   (13.06%).
    
   From the Phase II Premises Commencement Date through June 30, 2018,   “Tenant’s Proportionate Share For Expenses” shall be twenty-five and 48/100   percent (25.48%).
    
   From July 1, 2018 through the Termination Date, “Tenant’s Proportionate   Share For Expenses” shall be 25.81%.
    
	
 
    	
 
    	
 
    
	
TENANT’S PROPORTIONATE SHARE FOR TAXES:
    	
 
    	
From the Commencement Date through the day   immediately preceding the Phase II Premises Commencement Date, “Tenant’s   Proportionate Share For Taxes” shall be three and 94/100 percent (3.94%)   (which is the percentage derived by dividing the Premises Rentable Area for   the Phase I Premises for the period prior to the Phase II Premises   Commencement Date by the Rentable Square Footage of the “Parcel” (as such   term is defined in Section 4.1.3) and multiplying the result thereof by   100).
    
   From the Phase II Premises Commencement Date through June 30, 2018,   “Tenant’s Proportionate Share For Taxes” shall be seven and 68/100 percent   (7.68%) (which is the percentage derived by dividing the Premises Rentable   Area for the Premises for the period following the Phase II Premises   Commencement Date by the Rentable Square Footage of the “Parcel” (as such   term is defined in Section 4.1.3) and multiplying the result thereof by   100).
    
   From July 1, 2018 through the Termination Date, “Tenant’s Proportionate   Share For Taxes” shall be seven and 91/100 percent (7.91%) (which is the   percentage derived by dividing the Premises Rentable Area for the Premises   for the period following July 1, 2018 by the Rentable Square Footage of   the “Parcel” (as such term is defined in Section 4.1.3) and multiplying   the result thereof by 100).
    

 

S-4

 

	
SECURITY DEPOSIT:
    	
 
    	
Two Hundred Twenty-Seven Thousand Five Hundred   Thirty-Nine and No/100 Dollars ($227,539.00), subject to reduction to One   Hundred Thirteen Thousand Seven Hundred Sixty-Nine and 49/100 Dollars   ($113,769.49) pursuant to the terms and provisions of Article 5 and   Section 6 of the Second Amendment, and subject generally to the terms   and provisions of Article 5.
    
	
 
    	
 
    	
 
    
	
ASSIGNMENT/SUBLETTING FEE:
    	
 
    	
None.
    
	
 
    	
 
    	
 
    
	
AFTER-HOURS HVAC COST:
    	
 
    	
$35.00 per unit per hour, subject to change at any   time.
    
	
 
    	
 
    	
 
    
	
PARKING:
    	
 
    	
Sixty-six (66) non-exclusive parking spaces, subject   to the terms and provisions of Article 30.
    
	
 
    	
 
    	
 
    
	
REAL ESTATE BROKERS DUE COMMISSIONS:
    	
 
    	
Newmark Grubb Knight Frank and Cushman &   Wakefield of Massachusetts, Inc., to be paid by Landlord.
    
	
 
    	
 
    	
 
    
	
TENANT’S NAICS CODE:
    	
 
    	
339113
    
	
 
    	
 
    	
 
    
	
BUILDING BUSINESS HOURS:
    	
 
    	
8 a.m. to 6 p.m., Monday through Friday; 8   a.m. to 1 p.m., Saturday.
    
	
 
    	
 
    	
 
    
	
AMORTIZATION RATE:
    	
 
    	
Eleven percent (11%).
    

 

The Reference Pages information is incorporated into and made a part of the Lease.  In the event of any conflict between any Reference Pages information and the Lease, the Lease shall control.  This Lease includes Exhibits A through D, all of which are made a part of this Lease.

 

[END OF TEXT]

 

S-5

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