Document:

Exhibit 10.22

REVISED THIRD AMENDMENT

to

LEASE BETWEEN

 

EMERY STATION OFFICE II, LLC (LANDLORD)

And

KINEMED, INC. (TENANT)

 

EMERYSTATION NORTH PROJECT

Emeryville, California

 

That certain Lease dated May 5, 2002 by
and between Emery Station Office II, LLC (successor-in-interest to Emery Station Associates II, LLC), as Landlord, and KineMed,
Inc., as Tenant, (the “Original Lease”) as such was amended via First, Second and Third Amendments, is hereby further
amended as follows (the Original Lease as amended previously by the First, Second and Third Amendments and now by this Revised
Third Amendment are collectively the “Lease”):

 

		I.	The effective date of this Revised Third Amendment shall be February 28, 2005 (the “Revised Third Amendment Effective
Date”).

 

		II.	Pursuant to the terms of the Second Amendment, Tenant agreed to lease from Landlord the so-called Additional Space measuring
4,537 rentable square feet. It was Landlord's and Tenant's original intention that the lease term and rent on this Additional Space
commence upon substantial completion of the improvements to be installed by Landlord in the Additional Space. To accommodate the
different timetables for the Improvements planned for the former Thios HTS Lab and the former Thios vivarium which make up the
Additional Space, and to accommodate Tenant's desire to occupy ready spaces as soon as they are available, Landlord and Tenant
have now agreed to commence the term on the HTS Lab space upon Substantial Completion of those Improvements and to separately commence
the term on the vivarium space upon Substantial Completion of the Improvements in that area, and to adjust the rent due as a result
as well.

 

		III.	Landlord and Tenant hereby acknowledge that Substantial Completion of the Improvements to the former Thios HTS Lab space occurred
February 25, 2005. Pursuant to the terms of the Lease and Work Letter, Tenant had approved the plans by Gicklhorn Lazzarooto Partners
dated March 2, 2005 and labeled Bid Set (the “Construction Drawings”) for the Improvements to the former Thios vivarium
space, which plans were bid out by the Landlord and an estimated cost supplied to Tenant on March 16, 2005. Tenant has subsequently
decided to change its plans for improvements to the space. Landlord, at Landlord's expense, will close the holes in the vivarium
and prep it for Tenant's use as discussed. Tenant will pay the costs related to design/pre-development of the larger project, including
the Construction Drawings. These plans will remain available for Tenant's later use as appropriate. Tenant agrees to implement
sound-isolation measures detailed in the drawings separately. The former Thios vivarium space will be ready for Tenant's occupancy
no later than 4/1/05, and 4/1/05 shall be the formal commencement date for the former Thios Vivarium space.

 

    	 

    	 

    

 

		IV.	Section. IV of the Second Amendment is amended to extend further the Expiration Date of the Term of the Lease from December
31, 2009 to March 31, 2010.

 

		V.	Section V of the Second Amendment is therefore deleted and replaced with the following:

 

Monthly Triple Net Base Rent applicable to the Additional
Space shall be as follows:

 

	*	February 25, 2005 to March 24, 2005:	$0.00
	*	Beginning March 25, 2005:	$6,492.58 per month
	*	Beginning May 1, 2005:	$12,985.15 per month

 

On May 1, 2006 and every year thereafter this Monthly
Triple Net Rent applicable to the Additional Space shall be increased by three percent (3%).

 

Tenant shall be responsible to pay (via Rent Adjustment
Deposits and Rent Adjustments) fifty percent (50%) of all Operating expenses and Taxes applicable to the Additional Space beginning
February 25, 2005, increasing to one hundred percent (100%) at April 1, 2005.

 

		VI.	Section VII is amended to confirm that the Warrant described in Section VII was issued in the name of Emery Station Office
II, LLC, the successor-in-interest to Emery Station Associates II, LLC, and has been delivered Landlord.

 

		VII.	Tenant hereby represents to Landlord that it has represented itself in this transaction and that no brokerage commission will
be payable to any Tenant broker or representative as a result hereof.

 

		VIII.	Except for those terms outlined above, all other terms and conditions of the Original Lease (as amended) and Work Letter shall
apply.

 

In witness hereof, the parties have executed this Revised Third
Amendment as of the date noted below.

 

	TENANT:	 	LANDLORD:
	 	 	 
	KineMed, Inc., a Delaware Corporation	 	Emery Station Office II LLC, a 
	 	 	California Limited Liability Company

 

	By: 	/s/ David M. Fineman	 	By: 	/s/ Richard Robbins

 

	Print Name: 	David Fineman	 	Print Name: 	Richard K. Robbins

 

	Its: 	President & Chief Executive Officer	 	Its: 	 

 

	Dated: March 23, 2005	 	Dated:Exhibit 10.23

REVISED FOURTH AMENDMENT

to

LEASE BETWEEN

EMERY STATION OFFICE II, LLC (LANDLORD)

and

KINEMED, INC. (TENANT)

 

EMERYSTATION NORTH PROJECT

Emeryville, California

 

That certain Lease dated May 5, 2002 by
and between Emery Station Office II, LLC (successor-in-interest to Emery Station Associates II, LLC), as Landlord, and KineMed,
Inc., as Tenant, (the "Original Lease") as such was amended via First Amendment executed on June 27, 2003 (the "First
Amendment"), further amended via Second Amendment whose Effective Date was December 1, 2004 (the "Second Amendment")
and further amended via Revised Third Amendment whose Effective Date was February 28, 2005, is hereby further amended as follows
(the Original Lease as amended previously by the First, Second, and Revised Third Amendments and now by this
Revised Fourth Amendment is collectively the "Lease"):

 

		I.	The effective date of this Revised Fourth Amendment shall be March 15, 2005 (the “Revised
Fourth Amendment Effective Date”).

 

		II.	The premises covered under the Original Lease and the First, Second, and Revised
Third Amendments measures 14,522 rentable square feet (the "Current Space"). Pursuant to the terms herein, that
space shall be expanded to include additional space on the fourth floor more specifically depicted on Exhibit A attached hereto.
This additional space (herein, the "Executive Office Space") measures 2,910 rentable square feet. The Current Space of
14,522 rentable square feet and the Executive Office Space of 2,910 rentable square feet, together measuring 17,432 rentable square
feet, shall be considered the "Premises" for all purposes under the Lease.

 

		III.	Monthly Triple Net Base Rent applicable to the Executive Office Space shall be as follows: From Substantial Completion of the
Landlord Work (as defined below) through - 3/31/06: $4,714.20 per month.

 

On 4/1/06 and every year thereafter
this Monthly Triple Net Base Rent applicable to the Executive Office Space shall be increased by two and twenty-five hundredths
percent (2.25%).

 

		IV.	Tenant shall be responsible to pay (via Rent Adjustment Deposits and Rent Adjustments) all Operating
Expenses and Taxes applicable to the Executive Office Space during the lease term, as described herein, pursuant to the terms of
the Original Lease and this Revised Fourth Amendment.

 

    	 

    	 

    

 

		V.	Tenant agrees to accept the Executive Office Space in its current as-is condition subject only
to Landlord completing the following at Landlord's sole cost and expense (the "Landlord's Work): installation of a door with
a lock connecting the conference room and the existing medical exam room and installing signs on each side of the door that say
no exit to avoid confusion in case of an emergency. Landlord will complete this work so that Tenant can occupy the Executive Office
Space no later than 4/1/05, on which date the lease term on such space will commence.

 

Additional work agreed to be
performed by Landlord will be delayed. Landlord agrees to perform the following work in the future when requested by Tenant. Such
work consists of enlargement of the existing break room and commensurate shrinking of the existing conference room via relocation
of the wall and placement of matching VCT tiles in the expanded break room area where conference room carpet now exists. The cost
of this work shall be Landlord's responsibility, but this scope of work will be put "on the shelf' with Landlord.

 

		VI.	The amount of unreserved parking spaces available to Tenant under the lease, after addition of
the Executive Office Space to the Premises, shall be increased up to a total of up to fifty-three (53) spaces. Parking spaces up
to this amount shall be available to Tenant at rates and terms for parking described in Section 2.5 of the Original Lease.

 

		VII.	Tenant hereby represents to Landlord that it has represented itself in this transaction and that
no brokerage commission will be payable to any Tenant broker or representative as a result hereof.

 

		VIII.	The terms and conditions of the Work Letter attached as Exhibit B
to the Original Lease shall apply; however Sections 2.1 and 2.3 of Paragraph 2, entitled Design Matters, shall refer to the
improvements described in ¶ V above. Except for those terms outlined herein, all other terms
and conditions of the Lease and Work Letter shall apply.

 

In witness hereof, the parties have executed
this Fourth Amendment as of the Fourth Amendment Effective Date set forth above.

 

	TENANT:	LANDLORD:
	 	 
	KineMed, Inc., a Delaware Corporation	Emery Station Office II LLC, a 
	 	California Limited Liability Company

 

	By:	/s/ David M. Fineman	 	By: 	/s/ Richard K. Robbins

 

	Print Name:	David M. Fineman	 	Print Name: 	Richard K. Robbins

 

	Its:	President & Chief Executive Officer	 	Its:	 

 

	Dated: March 23, 2005	 	Dated: March     , 2005Exhibit 10.24

SEVENTH AMENDMENT

to

LEASE BETWEEN

EMERY STATION OFFICE II, LLC (LANDLORD)

And

KINEMED, INC. (TENANT)

 

EMERYSTATION NORTH PROJECT

Emeryville, California

 

That certain Lease dated May 5, 2002 by and between Emery Station
Office II, LLC (successor-in-interest to Emery Station Associates II, LLC), as Landlord, and KineMed, Inc., as Tenant, (the “Original
Lease”) as such was amended via First Amendment executed on June 27, 2003 (the “First Amendment”), via Second
Amendment whose effective date was December 1, 2004 (the “Second Amendment”), via Revised Third Amendment whose effective
date was February 28, 2005 (the “Third Amendment”), via Revised Fourth Amendment whose effective date was March 15,
2005 (the “Fourth Amendment”), via Fifth Amendment whose effective date was August 31, 2008 (the “Fifth Amendment”),
and via Sixth Amendment whose effective date was December 1, 2008 (the “Sixth Amendment”), is hereby further amended
as follows (the Original Lease as amended previously by the First, Second, Third, Fourth, Fifth and Sixth Amendments, and now by
this Seventh Amendment, are collectively referred to as the “Lease”). The effective date of this Seventh Amendment
shall be May 1, 2009 (the “Seventh Amendment Effective Date”).

 

		1.	Effective June 1, 2009, the Premises shall be expanded to include that 2,559 rentable square foot suite more specifically defined
on Exhibit A-1 hereof (the “Seventh Amendment Lab Space”). Tenant shall have the right to commence it's move-in to
the Seventh Amendment Lab Space as early as May 25, 2009, such Tenant occupancy prior to June 1, 2009 being pursuant to all the
terms of the Lease other than the obligation to pay Rent on the Seventh Amendment Lab Space. Tenant shall accept the Seventh Amendment
Lab Space in its existing as-is condition. After inclusion of the Seventh Amendment Lab space, Tenant's Premises shall total 15,454
rentable square feet.

 

		2.	The Lease shall be extended such that its Expiry Date shall be May 31, 2012.

 

		3.	Monthly Base Rent for the Premises shall be as follows:
	 	 	 

		·	Prior to June 1, 2009: per the terms of the Lease prior to this Seventh Amendment.

		·	For the period of June 1 - 31, 2009: $37,008.64

		·	           

		·	For July 1, 2009 - June 30, 2010: $44,352.98 monthly

Commencing June 30, 2010 and annually thereafter,
Monthly Base Rent shall be increased by three percent (3%) annually. In addition to the Monthly Base Rent outlined above, Tenant
shall remain obligated to pay all Rent Adjustment Deposits and Rent Adjustments called for by the Lease. Tenant shall also remain
obligated to pay the agreed amortization of Base Rent Deferrals referenced in prior Lease amendments until said Base Rent Deferrals
are paid in full.

 

    	 

    	 

    

 

		4.	Subject to the rights of other tenants pursuant to leases in effect as of the Date of Lease, Tenant shall have a one-time right
of first offer to lease the “Vivarium Space” on the fourth (4th) floor of the Building as it becomes available (the
“Right of First Opportunity”). As used in this Section 4, “Vivarium Space” shall mean that
existing 1,938 rentable square foot vivarium formerly occupied by Tenant and more specifically outlined in Exhibit A-2 hereof.
Upon the earlier to occur of a) Landlord proposes to enter into a letter of intent or some other form of agreed set of primary
lease terms for a lease lasting longer than six (6) months with a prospective tenant for lease of the Vivarium Space, orb) December
31, 2009, Landlord shall give written notice thereof to Tenant (the “ROFO Offer Notice”).Tenant shall have a
period of five (5) business days after receipt of Landlord's ROFO Offer Notice to determine and notify Landlord formally, in writing,
that its elects to lease the Vivarium Space on the following terms:

*on
an “as-is” basis,

*for
a term expiring at the same time as the balance of Tenant's space (namely March 31, 2013),

*at
the same Monthly Base Rental Rate, calculated on a per rentable square foot basis, as is applicable to Tenant's base Lease, and 

*requiring
Tenant's Security Deposit to be increased by $5,562.06

 

Tenant's written notice to Landlord of its election
to lease the Vivarium Space shall be referred to as “Tenant's Vivarium Space Acceptance Notice”. Failure by Tenant
to send Landlord Tenant's Vivarium Space Acceptance Notice shall be deemed Tenant's election not to lease said space, in which
case Landlord shall be free to enter into a lease thereof with any other party on any other terms Landlord shall elect in its sole
and absolute discretion.

 

 

Notwithstanding anything to the contrary contained
herein, all rights of Tenant pursuant to this Section 4 with respect to the Vivarium Space shall, at Landlord's election upon notice
to Tenant, be of no further force or effect with respect to the Vivarium Space, whether or not Tenant has timely exercised the
Right of First Offer granted herein with respect thereto, and Landlord shall have no obligation to deliver any ROFO Offer Notice
to Tenant with respect to the Vivarium Space, if a Default exists at the time of exercise of the Right of First Offer, or at the
time that Landlord would otherwise be required to deliver such ROFO Offer Notice, or at the time of commencement of the term of
the lease for the Vivarium Space.

 

If Tenant sends Landlord Tenant's Vivarium Space
Acceptance Notice, pursuant to this Section 4, Landlord promptly shall prepare such a lease amendment setting forth the agreed
terms and conditions for the Vivarium Space and Tenant shall promptly execute same and return it to Landlord..

 

    	 

    	 

    

 

		5.	Simultaneously with the mutual execution hereof, the Security Deposit shall be increased by $7,344.33. Tenant shall remit this
amount to Landlord together with its signed copy of the Seventh Amendment.

 

		6.	Tenant hereby represents to Landlord that Jonathan Tomasco of Cornish & Carey has been its broker representative in this
transaction and that, other than to him, no brokerage commission will be payable to any tenant broker or representative as a result
hereof.

 

		7.	Except for those terms outlined herein, all other terms and conditions of the Lease and Work Letter
shall apply.

 

In witness hereof, the parties have executed this Seventh Amendment
as of the date noted below.

 

	TENANT:	 	LANDLORD:
	 	 	 
	KineMed, Inc., a Delaware Corporation	 	Emery Station Office II LLC, a 
	 	 	California Limited Liability Company
	 	 	 	 
	By:	/s/ David M. Fineman	 	By:	/s/ Richard K Robbins
	 	 	 	 	 
	Print Name: 	David M. Fineman	 	Print Name: 	 
	 	 	 	 	 
	Its: 	President	 	Its: 	 
	 	 	 	 	 
	Dated: 5/1/09	 	Dated: 5/09/09

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