Document:

Amendment No. 1 to Exclusive License Agreement

 EXHIBIT 10.2 
 AMENDMENT No. 1 to 
 EXCLUSIVE LICENSE AGREEMENT 

MGH Amendment Agreement No: 2006A20644 
 MGH Case No: 1814 
 This Amendment No. 1 (this
“AMENDMENT”), effective as of January 23rd, 2006, (“AMENDMENT EFFECTIVE DATE”), amends the Exclusive License Agreement, MGH Agreement No. 2004A18946, dated May 17th, 2005, and any subsequent amendments (collectively, the
“AGREEMENT”), between The General Hospital Corporation, a not-for-profit corporation d/b/a Massachusetts General Hospital, having a place of business at 55 Fruit Street, Boston, MA 02114 (“HOSPITAL”) and Juniper Medical, Inc. a
Delaware corporation, having a principal place of business at 7139 Koll Center Parkway, Suite 300, Pleasanton, CA 94566(“COMPANY”). 
 The parties have entered into the AGREEMENT and now wish to amend it as set forth below. 
 For good and valuable consideration, the sufficiency of which is hereby acknowledged, the parties agree as follows. 
  

	 	1.	Supplement Article 1, entitled “CERTAIN DEFINITIONS” by inserting the following new provision: 

1.27 “DISTRIBUTION 510(k) or PMA APPLICATION” shall mean a 510(k) or PMA APPLICATION that is filed by the COMPANY with the
United States Food and Drug Administration with the intent to make available for distribution a PRODUCT in the United States. For purposes of this Section 1.27, manufacturing scale-up of a PRODUCT for distribution shall be deemed as
“intent to make available for distribution a PRODUCT”. 
  

	 	4.	Amend Article 4.4 (a) by deleting it in its entirety and replacing it with the following: 

4.4 (a) Four Hundred Thousand Dollars ($400,000.00) within thirty (30) days of the earlier of (i) submission of a protocol
for the first pivotal clinical trial under an IDE or (ii) first DISTRIBUTION 510(k) or PMA APPLICATION for a PRODUCT or PROCESS. 
 Except as specifically modified in this Amendment, all terms and conditions of the Agreement shall remain in full force and effect. 
 The parties have duly executed this Amendment as of the AMENDMENT EFFECTIVE DATE. 
  

									
		 	        COMPANY	 		 		 	       HOSPITAL
					
	BY:	 	   /s/ Mitchell Levinson
	 		 	BY:	 	        /s/ Irina Erenburg, Ph.D.

		 		 		 		 	        Irina Erenburg, Ph.D.
        Associate Director

									
	TITLE:	 	   President
	 		 	TITLE:	 	   Corporate Sponsored Research and Licensing

					
	DATE:	 	   1-25-06
	 		 	DATE:	 	   1-25-06Amendment No. 2 to Exclusive License Agreement

 EXHIBIT 10.3 
 AMENDMENT No. 2 to 
 EXCLUSIVE LICENSE AGREEMENT 

MGH Amendment Agreement
No:                     
 MGH Case No.: 1814 
 This Amendment No. 2 (“AMENDMENT NO. 2”),
effective as of May 17TH, 2010, (“AMENDMENT NO. 2 EFFECTIVE DATE”), amends the Exclusive License Agreement, MGH Agreement No. 2004A18936, dated May 17, 2005, and any subsequent amendments including an Amendment No. 1
effective as of January 23rd, 2006 (collectively the “AGREEMENT”), between The General Hospital Corporation, a not-for-profit corporation d/b/a Massachusetts General Hospital, having a place of business at 55 Fruit Street, Boston, MA
02114 (“HOSPITAL”) and Juniper Medical, Inc., a Delaware corporation, having a principal place of business at 7139 Koll Center Parkway, Suite 300, Pleasanton, CA 94566, which changed its name to Zeltiq Aesthetics, Inc., a Delaware
corporation, having a principal place of business at 4698 Willow Road, Pleasanton, CA 94588 (“COMPANY”). 
 The
parties have entered into the AGREEMENT and now wish to further amend it as set forth below. 
 For good and valuable
consideration, the sufficiency and receipt of which is hereby acknowledged, the parties agree as follows: 
 1.
Section 3.1(a)(viii) is hereby deleted in its entirety and shall be void ab initio. 
 2. Section 4.4 is hereby
amended and restated in its entirety as follows: 
 4.4 Milestone Payments. In addition to the payments
set forth in Sections 4.1 through 4.3 above, COMPANY shall pay HOSPITAL milestone payments as follows: 
  

	 	4.4(a)	One Million Fifty Thousand Dollars ($1,050,000 US) upon the earlier of January 5, 2011 or receiving FDA clearance or approval of the submission titled Request for
evaluation of automatic class III designation for the ZELTIQTM dermal cooling device and dated October 14, 2009. 

  

	 	4.4(b)	One Million Dollars ($1,000,000 US) within forty- five (45) days of reaching cumulative worldwide NET SALES of PRODUCTS and PROCESSES in the amount of Seventy
Million U.S. Dollars ($70,000,000). 

	 	4.4(c)	Six Million Dollars ($6,000,000 US) within forty- five (45) days of the earlier of: 

 

	 	(i)	reaching cumulative worldwide NET SALES of PRODUCTS and PROCESSES in the amount of Two Hundred Million U.S. Dollars ($200,000,000); 

provided however, if at the time the COMPANY reaches cumulative worldwide NET SALES of PRODUCTS and PROCESSES in the amount of
$200,000,000 a CHANGE OF CONTROL EVENT has not yet occurred and the COMPANY is still privately held, then payment of the amount specified above in this 4.4(c) shall be made in two installments: the first installment of Three Million U.S. Dollars
($3,000,000) shall be made within 45 days after the COMPANY reaches $200,000,000 in cumulative worldwide NET SALES; the second installment of Three Million U.S. Dollars ($3,000,000) shall be made exactly one (1) year thereafter; or 

 

	 	(ii)	first CHANGE OF CONTROL 

provided however, if at the time such CHANGE OF CONTROL occurs, 

 

	 	1)	the CHANGE OF CONTROL is not an IPO event, and the total consideration paid for all of the assets or shares of the Company is less than the sum of the aggregate
invested capital invested in the COMPANY from inception, plus Six Million U.S. Dollars ($6,000,000); or 

  

	 	2)	the CHANGE OF CONTROL is an IPO event, and the price per share at which the shares are offered to the public reflects a pre-money valuation of the COMPANY that is less
than the sum of the aggregate capital invested in the COMPANY from inception, plus $6,000,000; 

 then, the
milestone payment in 4.4(c) is payable only when the COMPANY or its successor reaches cumulative worldwide NET SALES of PRODUCTS and PROCESSES in the amount of $200,000,000 as provided in 4.4(c)(i) above. 

As of the AMENDMENT NO. 2 EFFECTIVE DATE, the aggregate invested capital in the COMPANY from its inception is approximately Fifty Two
Million Six Hundred Thousand U.S. Dollars ($52,600,000) and the number of fully 

 
diluted shares outstanding is approximately 68,500,000 (in each case prior to any Series D investment). For purposes of illustration only, based on the invested capital and the number of fully
diluted shares described above in this paragraph, an IPO event would have to be priced at approximately $0.86 per share or more for the milestone payment described in Section 4.4(c) to be payable within forty five (45) days after such IPO
event. An example calculation is as follows: 
 $52.6M  

+$6M  

$58.6M 

/ 68.5M shares  
 $0.86/share 
 Aggregate stock issuance to HOSPITAL discussed below shall not
exceed in the aggregate 3.5% of fully-diluted equity of the COMPANY. 
 COMPANY shall notify HOSPITAL of the achievement of the
$1,050,000 milestone, the $1,000,000 milestone, and the $6,000,000 milestone set forth in Sections 4.4(a)-(c), respectively. HOSPITAL may elect to receive up to 50% of any of amounts due under subsections (a), (b), and (c) above in COMPANY
Common Stock or non-voting SPECIAL PREFERRED STOCK (as defined below), at such time as COMPANY achieves such milestones, by (i) notifying the COMPANY in writing of such election within thirty (30) days of notification by COMPANY of
COMPANY’s achievement of such milestone, and (ii) agreeing to customary restrictions and representations required, in the reasonable opinion of COMPANY’S legal counsel, to comply with the rules and regulations promulgated by the
United States Securities and Exchange Commission and other applicable laws. In the event that HOSPITAL elects to receive any of the aforementioned amounts due under subsections (a), (b), and (c) above in COMPANY stock, COMPANY shall use
commercially reasonable efforts to obtain any required consents and/or waivers, within thirty (30) days from receipt of HOSPITAL’S notice, to authorize such shares of COMPANY Common Stock or Special Preferred Stock and to effectuate such
COMPANY stock issuance, which period may be extended as mutually agreed to by the PARTIES in writing. Any Special Preferred Stock issued to HOSPITAL pursuant to this Section 4.4 shall be issued upon the same terms and conditions as provided to
investors of the round of financing immediately prior to such milestone payment (except that such shares shall be non-voting), and valued at the per share price of the more recent of (i) a last round of financing or (ii) an independent
valuation (performed annually in accordance with IRS guidelines)(such shares, once authorized, the “SPECIAL PREFERRED STOCK”). 
 Once COMPANY has made any particular milestone payment under Section 4.4, COMPANY will not be obligated to make any payment under Section 4.4 with respect to the
re-

 
occurrence of the same milestone. For example, the milestone payments in Sections 4.4(a)-(c) are one-time payments for only the first occurrence of each such milestone, as opposed to annual
milestone payments based on annual NET SALES of PRODUCTS and/or PROCESSES in the United States. 
 In the event that COMPANY
achieves any of the foregoing milestones through a SUBLICENSEE, and the sublicense agreement with such SUBLICENSEE provides for a milestone payment for such milestone event, which payment also meets the definition of SUBLICENSING INCOME under
Section 4.6, COMPANY shall first pay HOSPITAL the milestone payment as payable hereinabove. In the event that the amount of SUBLICENSE INCOME associated with the achievement of such milestone exceeds the amount payable to HOSPITAL for
achievement of such milestone as set forth above, then COMPANY shall also pay the appropriate percentage of the excess as a non-royalty SUBLICENSE INCOME payment, as provided in Section 4.6 below. For example, in the event that COMPANY meets
its milestone obligation in Section 4.4(b) through a SUBLICENSEE’S achievement of such milestone, and such SUBLICENSEE’S sublicense agreement with COMPANY provides for payment by SUBLICENSEE of a $1,500,000 milestone payment to
COMPANY on the same event as described in Section 4.4(b), the COMPANY shall first pay HOSPITAL the $1,000,000 payment as provided in Section 4.4(b), and shall then pay 50% of the remaining $500,000 SUBLICENSING INCOME as provided in
Section 4.6(a) below. 
 3. For the purpose of this AMENDMENT NO. 2 and as such terms are used in the in Sections 1.15 (NET SALES
definition) and Section 4 of the AGREEMENT, the term PRODUCT shall mean any and all PATENT PRODUCT and ACCESSORY PRODUCT, and the term PROCESS shall mean any and all PATENT PROCESS and ACCESSORY PROCESS. 

4. Except as specifically modified in the AMENDMENT NO. 2, all terms and conditions of the AGREEMENT shall remain in full force and effect. 

5. The parties have duly executed this AMENDMENT NO. 2 as of the AMENDMENT NO. 2 EFFECTIVE DATE. 

 

									
	COMPANY	 		 	HOSPITAL
					
	BY:	 	  /s/ Gordie Nye
	 		 	 BY:	 	         /s/ Irina
Erenburg

									
	TITLE:	 	   CEO
	 		 	TITLE:	 	   Director

	DATE:	 	   5/25/10
	 		 	DATE:	 	   5/25/10

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