Document:

Exhibit
4.1

 

[FACE OF CERTIFICATE]

 

[LOGO]

 

NUMBER

BST

 

SHARES

 

INCORPORATED
UNDER THE LAWS OF THE STATE OF DELAWARE

 

THIS
CERTIFICATE IS TRANSFERABLE IN THE CITY OF BOSTON, MA OR NEW YORK, NY

 

SEE REVERSE
FOR CERTAIN DEFINITIONS AND A STATEMENT AS TO RIGHTS, PREFERENCES, PRIVILEGES
AND RESTRICTIONS, IF ANY

 

CUSIP 090945
10 6

 

This
Certifies that

 

is the
record holder of

 

FULLY PAID
AND NONASSESSABLE SHARES OF COMMON STOCK, $.01 PAR VALUE PER SHARE, OF

 

BIOSITE
INCORPORATED

 

transferable
on the books of the Corporation by the holder hereof in person or by duly
authorized Attorney upon surrender of this certificate properly endorsed. This
certificate is not valid until countersigned by the Transfer Agent and
registered by the Registrar. WITNESS the facsimile seal of the Corporation and
the facsimile signatures of its duly authorized officers.

 

Dated

 

VICE
PRESIDENT, FINANCE AND CHIEF FINANCIAL OFFICER

 

PRESIDENT
AND CHIEF EXECUTIVE OFFICER

 

COUNTERSIGNED
AND REGISTERED: AMERICAN STOCK TRANSFER & TRUST COMPANY TRANSFER AGENT AND
REGISTRAR

 

	
  BY

  	
   

  	
   

  	
   

  
	
   

  
	
  AUTHORIZED
  SIGNATURE

  

 

 

[BACK OF
CERTIFICATE]

 

A statement
of the powers, designations, preferences and relative, participating, optional
or other special rights of each class of stock or series thereof and the qualifications,
limitations or restrictions of such preferences and/or rights as established,
from time to time, by the Certificate of Incorporation of the Corporation and
by any certificate of determination, the number of shares constituting each
class and series, and the designations thereof, may be obtained by the holder
hereof upon request and without charge at the principal office of the
Corporation.

 

This
certificate also evidences and entitles the holder hereof to certain Rights as
set forth in a Rights Agreement between Biosite Incorporated (the “Company”)
and American Stock Transfer & Trust Company (the “Rights Agent”) dated as
of March 1, 2000, as amended from time to time (the “Rights Agreement”), the
terms of which are hereby incorporated herein by reference and a copy of which
is on file at the principal offices of the Company. Under certain
circumstances, as set forth in the Rights Agreement, such Rights may be
redeemed, may expire or may be evidenced by separate Certificates and will no
longer be evidenced by this Certificate. The Company will mail to the holder of
this certificate a copy of the Rights Agreement without charge within five days
after receipt of a written request therefor. Under certain circumstances,
Rights issued to Acquiring Person (as defined in the Rights Agreement) or
certain related Persons and any subsequent holder of such Rights may become
null and void.

 

The
following abbreviations, when used in the inscription on the face of this
certificate, shall be construed as though they were written out in full
according to applicable laws or regulations:

 

TEN COM — as
tenants in common TEN ENT — as tenants by the entireties JT TEN — as joint
tenants with right of survivorship and not as tenants in common

 

UNIF GIFT
MIN ACT —                               
Custodian

                                                  
(Cust) (Minor) under Uniform Gifts to Minors Act

(State)

UNIF TRF MIN ACT —
                
Custodian (until age
                )

(Cust)

under Uniform Transfers (Minor) to Minors Act

(State)

 

Additional
abbreviations may also be used though not in the above list.

 

FOR VALUE
RECEIVED, hereby sell, assign and transfer unto

 

 

2

 

PLEASE
INSERT SOCIAL SECURITY OR OTHER IDENTIFYING NUMBER OF ASSIGNEE

 

(PLEASE
PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)

 

Shares of
the common stock represented by the within Certificate, and do hereby
irrevocably constitute and
appoint                               

Attorney to
transfer the said stock on the books of the within named Corporation with full
power of substitution in the premises. Dated

 

NOTICE: THE
SIGNATURE(S) TO THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME(S) AS WRITTEN
UPON THE FACE OF THE CERTIFICATE IN EVERY PARTICULAR, WITHOUT ALTERATION OR
ENLARGEMENT OR ANY CHANGE WHATEVER.

 

Signature
(s) Guaranteed

 

	
  By

  	
   

  	
   

  	
   

  

 

THE
SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (BANKS,
STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP
IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM), PURSUANT TO S.E.C. RULE
17Ad-15.

 

3Exhibit
10.34

 

THIRD AMENDMENT TO

PURCHASE AGREEMENT AND ESCROW INSTRUCTIONS

 

THIS THIRD AMENDMENT TO PURCHASE AGREEMENT AND ESCROW
INSTRUCTIONS (“Amendment”) is entered into at San Diego, California as of June
10, 2002, between H. G. FENTON COMPANY, a California corporation which acquired
title as H. G. Fenton Material Company (“Seller”), and BIOSITE INCORPORATED, a
Delaware corporation (“Buyer”), with reference to the following

 

R E C I
T A L S:

A.                                                                                   Seller
and Buyer are the parties to a Purchase Agreement and Escrow Instructions dated
as of December 7, 2001 and previously amended as of February 12 and February
14, 2002 (“Agreement”), relating to certain real property in the Carroll Canyon
area of San Diego, California as depicted on Exhibit A to the Agreement
(“Land”). Initially capitalized terms not otherwise defined in this Amendment
have the same meanings as in the Agreement, as previously amended. Pursuant to
the Agreement, the parties have established Escrow No. 51943-PM with Stewart
Title of California, Inc. as Escrow Holder.

 

B.                                                                                     The
Agreement establishes the Purchase Price as $24.50 per square foot of Net
Salable Area of the Land. At the time the Agreement was entered into, the
parties anticipated that the Net Salable Area would be 25.8 acres or 1,123,848
square feet, with the Purchase Price thus expected to be $27,534,276.The
Grading Certifications described below have now been delivered and approved by
Buyer, with the civil engineer certifying that the Net Salable Area is in fact
1,148,879.05 square feet, or 26.37 acres. The parties wish to modify the
Agreement to reflect the actual Purchase Price of $28,147,537.

 

THE PARTIES AGREE:

 

1.                                                                                       Grading
Certifications. Buyer acknowledges that it has received and approved each
of the following Grading Certifications, and agrees that the special condition
of Paragraph 6.1.5 of the Agreement has been satisfied:

 

(a)                                                                                                                                  Determination
of Net Salable Acres, dated April 15, 2002, prepared by Stuart Engineering
(with Area Exhibit);

 

(b)                                                                                                                                 As-Built
Elevations, dated April 15, 2002, prepared by Stuart Engineering (with
Elevation Exhibit), and

 

(c)                                                                                                                                  Final
Report of Testing and Observation Services During Grading, Biosite Project
Fenton Carroll Canyon Technology Center, Lots 1 through 10, Tentative Map No.
98-1199, San Diego, California, dated April 17, 2002, prepared by Geocon
Incorporated.

 

2.                                                                                       Purchase
Price. Based on the Net Salable Area as certified by the civil engineer’s
Grading Certification described in Paragraph 1(a), the parties acknowledge and
agree that the Purchase 

 

1

 

Price shall be
Twenty-Eight Million One Hundred Forty-Seven Thousand Five Hundred Thirty-Seven
Dollars ($28,147,537).

 

3.                                                                                       Other
Matters of Agreement.

 

(a)                                                                                                                                  This
Amendment may be executed in any number of counterparts, each of which will be
deemed to be an original, but all of which together will constitute one
instrument.

 

(b)                                                                                                                                 Except
to the extent modified hereby, all provisions of the Agreement as previously
amended shall remain in full force and effect.

 

	
  Seller:

  	
  Buyer:

  
	
   

  	
   

  
	
  H. G. FENTON
  COMPANY, a California

  corporation

  	
  BIOSITE
  INCORPORATED, a Delaware

  corporation

  
	
   

  	
   

  
	
   

  	
   

  
	
  By

  	
  /s/ Henry F.
  Hunte

  	
   

  	
  By

  	
  /s/ Christopher
  J. Twomey

  	
   

  
	
  Its

  	
  Chairman and CEO

  	
   

  	
  Its

  	
  V.P, Finance and
  Chief Financial Officer

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  By

  	
  /s/ Michael P.
  Neal

  	
   

  	
  By

  	
   

  	
   

  
	
  Its

  	
  President and
  C.O.O.

  	
   

  	
  Its

  	
   

  	
   

  

 

2Exhibit
10.35

 

FOURTH
AMENDMENT TO

PURCHASE AGREEMENT AND ESCROW INSTRUCTIONS

 

THIS FOURTH AMENDMENT TO PURCHASE AGREEMENT AND ESCROW
INSTRUCTIONS (“Amendment”) is entered into at San Diego, California as of
January 24, 2003, between H. G. FENTON COMPANY, a California corporation which
acquired title as H. G. Fenton Material Company (“Seller”), and BIOSITE
INCORPORATED, a Delaware corporation (“Buyer”), with reference to the following

 

R E C I
T A L S:

A.                                                                                   Seller
and Buyer are the parties to a Purchase Agreement and Escrow Instructions dated
as of December 7, 2001 and previously amended as of February 12, February 14,
and June 10, 2002 (“Agreement”), relating to certain real property in the
Carroll Canyon area of San Diego, California as depicted on Exhibit A to
the Agreement (“Land”). Initially capitalized terms not otherwise defined in
this Amendment have the same meanings as in the Agreement, as previously
amended. Pursuant to the Agreement, the parties have established Escrow No.
51943-PM with Stewart Title of California, Inc. as Escrow Holder.

 

B.                                                                                     The
Latest Closing Date under the Agreement as previously amended is currently
March 31, 2003. The parties wish to extend the Latest Closing Date by one
month.

 

THE PARTIES AGREE:

 

1.                                                                                       Extension
of Latest Closing Date. The parties agree that the definition of Latest
Closing Date shall be modified to read as follows:

 

“Latest Closing Date” means April 30, 2003,
which shall be extended day-for-day, to a maximum extension of six (6) months,
for each day of Unavoidable Delay that is caused by restrictions on grading or
other Pre-Closing Improvements incident to storm-water runoff requirements.

 

2.                                       Other
Matters of Agreement.

 

(a)                                                                                                                                  This
Amendment may be executed in any number of counterparts, each of which will be
deemed to be an original, but all of which together will constitute one
instrument.

 

(b)                                                                                                                                 Except
to the extent modified hereby, all provisions of the Agreement as previously
amended shall remain in full force and effect.

 

1

 

	
  Seller:

  	
  Buyer:

  
	
   

  	
   

  
	
  H. G. FENTON
  COMPANY, a California

  corporation

  	
  BIOSITE
  INCORPORATED, a Delaware

  corporation

  
	
   

  	
   

  
	
   

  	
   

  
	
  By

  	
   /s/ Michael P. Neal

  	
   

  	
  By

  	
   /s/ Christopher J. Twomey

  	
   

  
	
  Its

  	
   President and CEO

  	
   

  	
  Its

  	
   V.P. Finance and CFO

  	
   

  
	
   

  	
   

  
	
   

  	
   

  
	
  By

  	
   /s/ Allen Jones

  	
   

  	
  By

  	
   

  	
   

  
	
  Its

  	
   Vice President

  	
   

  	
  Its

  	
   

  	
   

  

 

2

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