Document:

EX-10.9

 Exhibit 10.9 

EMPLOYMENT AGREEMENT 

This EMPLOYMENT AGREEMENT (the
“Agreement”) is entered into effective September 23, 2016 (the “Effective Date”), by and between Avedro, Inc. (the “Company”) and Reza
Zadno, Ph.D. (the “Employee”). 
 Between July 11, 2016 and September 23, 2016, Employee
was employed as interim Chief Executive Officer (“CEO”) of the Company, pursuant to the terms of the July 11, 2016 offer letter; 

On September 23, 2016 the Company’s Board of Directors (“Board’’)
voted to change the Employee’s status from Interim CEO to permanent CEO; 
 Effective as of January 1, 2017, the Board
voted to increase Employee’s Base Salary as described in Section 2.1 herein; 
 The Company desires to continue to employ the
Employee in the capacity of full-time CEO pursuant to the terms of this Agreement and, in connection therewith, to compensate the Employee for Employee’s personal services to the Company; and 

The Employee wishes to be employed by the Company and provide personal services to the Company in return for certain compensation. 

Accordingly, in consideration of the mutual promises and covenants contained herein, the parties agree to the following: 

1.    EMPLOYMENT BY THE COMPANY.

 1.1    At-Will Employment. Employee shall be
employed by the Company on an “at-will” basis, meaning either the Company or Employee may terminate Employee’s employment at any time, with or without cause or advanced notice. Any contrary
representations that may have been made to Employee shall be superseded by this Agreement. This Agreement shall constitute the full and complete agreement between Employee and the Company on the “at-will” nature of Employee’s
employment with the Company, which may be changed only in an express written agreement signed by Employee and a duly authorized officer of the Company. Employee’s rights to any compensation following a termination shall be only as set forth in
Section 6. 
 1.2    Position. Subject to the terms set forth herein, the Company agrees
to employ Employee, initially in the position of CEO and Employee hereby accepts such employment. During the term of Employee’s employment with the Company, Employee will devote Employee’s best efforts and substantially all of
Employee’s business time and attention to the business of the Company. 
 1.3    Duties.
Employee will report to the Board and/or such other Board officers, company executives and/or committees designated by the Board, performing such duties as are normally associated with his then current position and such duties as are assigned to

 him from time to time, subject to the oversight and direction of the Board. Employee shall further serve as
a Director of the Board during the term of his employment. Employee shall perform his duties under this Agreement principally out of the Company’s corporate headquarters in Massachusetts or such other location as assigned. In addition, the
Employee shall make such business trips to such places as may be necessary or advisable for the efficient operations of the Company. 

1.4    Company Policies and Benefits. The employment relationship between the parties shall
also be subject to the Company’s personnel policies and procedures as they may be interpreted, adopted, revised or deleted from time to time in the Company’s sole discretion. The Employee will be eligible to participate on the same basis
as similarly situated employees in the Company’s benefit plans in effect from time to time during his employment. All matters of eligibility for coverage or benefits under any benefit plan shall be determined in accordance with the provisions
of such plan. The Company reserves the right to change, alter, or terminate any benefit plan in its sole discretion. Notwithstanding the foregoing, in the event that the terms of this Agreement differ from or are in conflict with the Company’s
general employment policies or practices, this Agreement shall control. 
 1.5    Paid Time Off.
The Employee will be eligible to accrue up to 15 days of paid vacation per calendar year, which accrues each bi-monthly pay period. In addition, the Employee will be eligible to take up to 6 sick days per
calendar year. Employee’s paid time off will be prorated based upon the Effective Date of this Agreement. 

2.    COMPENSATION. 

2.1    Salary. For the period of September 23, 2016 through December 31, 2016,
Employee shall receive for Employee’s services to be rendered hereunder an initial annualized base salary of $350,000 which shall be increased to $400,000 as of January 1, 2017 (“Base Salary”). The Base Salary is
subject to review and adjustment from time to time by the Company in its sole discretion, payable subject to standard federal and state payroll withholding requirements in accordance with Company’s standard payroll practices. 

2.2    Bonus. 

(a)    During Employment. Employee shall be eligible to earn an annual performance bonus of up to 50% of
his Base Salary (‘’Annual Bonus’’). The Annual Bonus will be based upon the Board’s assessment of the Employee’s performance and the Company’s attainment of targeted goals
as set by the Board in its sole discretion. The Annual Bonus, if any, will be subject to applicable payroll deductions and withholdings. Following the close of each calendar year, the Board will determine whether the Employee has earned the Annual
Bonus, and the amount of any Annual Bonus, based on the set criteria. No amount of the Annual Bonus is guaranteed, and the Employee must be an employee in good standing on the Annual Bonus payment date to be eligible to receive an Annual Bonus; no
partial or prorated bonuses will be provided. The Annual Bonus, if earned, will be paid no later than March 15 of the calendar year immediately following the applicable calendar year for which the Annual Bonus is being measured. The
Employee’s eligibility for an Annual Bonus is subject to change in the discretion of the Board (or any authorized committee thereof). 

  
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 (b)    Upon Termination. Subject to the prov1s1ons
of Section 6.1(b)(iii), in the event Employee leaves the employ of the Company for any reason prior to payment of any bonus, he is not eligible for such bonus, prorated or otherwise. 

2.3    Stock Option. 

(a)    Option Grant. On September 23, 2016, the Board issued the Employee options to purchase an
aggregate of 2,339,385 shares of the Company’s common stock pursuant. subject to the Company’s 2012 Equity Incentive Plan (“Plan”) and the Company’s standard form of Stock Option Agreement (“Stock
Agreement”) between the Employee and the Company. The option is an incentive stock option to the extent permissible under Section 422 of the Internal Revenue Code and has an exercise price per share of $0.40. 

(b)    Vesting. The Option is comprised of two separate grants: an option to purchase 236,500 shares
of the Company’s common stock (the “Interim CEO Grant”) and an option to purchase 2,105,885 shares of the Company’s common stock (the “CEO Grant” and together with the Interim CEO Grant. the
“Options”). 
 (i)    The Interim CEO Grant vests monthly in five equal installments over a
five month period beginning on August 12, 2016 (i.e., with August 12, 2016 being the first vesting date) (the “Vesting Commencement Date’’), subject to Employee’s continuous
services as of each such vesting date. 
 (ii)    The CEO Grant vests monthly in forty-eight (48) equal
installments over a four-year period for each month of continuous service beginning on the Vesting Commencement Date (i.e., with August 12, 2016 being the first vesting date), subject to Employee’s continuous service as of each such
vesting date. 
 (c)    Acceleration. In addition to the acceleration provided for in
Section 6.5(a)(y), in the event the Company consummates a Change in Control (as such term in defined in the Plan) (as defined, a “Change in Control”), then any then-unvested Options shall vest
immediately prior to, but subject to, the consummation of such Change in Control. 
 2.4    Expense
Reimbursement. The Company will reimburse Employee for all reasonable, documented business expenses incurred in connection with his services hereunder, in accordance with the Company’s business expense reimbursement policies and
procedures as may be in effect from time to time. 
 2.5    Home Travel Reimbursement. The
Company will reimburse Employee, subject to applicable taxes and withholdings, for reasonable travel expenses incurred in connection with Employee’s weekly travel from his home in California to the Company’s office in Massachusetts. The
Company has covered the cost of a corporate apartment for Employee’s use while at the Company’s offices in Massachusetts. Employee acknowledges that all reimbursements and/or benefits under this Section 2.5 will be taxable to
Employee. The reimbursement amount payable by the Company to the Employee pursuant to this Section 2.5 shall be “grossed up” so that on an after-tax basis the

  
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Company has paid to Employee, and the Employee retains, the amount otherwise payable pursuant to this Section 2.5 (i.e., the amount payable by the Company to the Employee shall equal
x divided by (y minus z) where (i) x is the amount of the reimbursement payment described above, (ii) y is equal to one and (iii) z is the federal and state blended tax rate applicable to such payment). 

3.    PROPRIETARY INFORMATION, INVENTIONS, NON-COMPETITION AND NON-SOLICITATION OBLIGATIONS.
The parties hereto have entered into a Proprietary Information, Inventions, Non-Competition and Non-Solicitation Agreement (the “Proprietary
Information Agreement”), which may be amended by the parties from time to time without regard to this Agreement. The Proprietary Information Agreement contains provisions that are intended by the parties to
survive and do survive termination or expiration of this Agreement. 
 4.    OUTSIDE
ACTIVITIES. Except with the prior written consent of the Company’s Board, Employee will not, while employed by the Company, undertake or engage in any other employment,
occupation or business enterprise that would interfere with Employee’s responsibilities and the performance of Employee’s duties hereunder except for (i) reasonable time devoted to volunteer services for or on behalf of such
religious, educational, non-profit and/or other charitable organization as Employee may wish to serve; (ii) reasonable time devoted to activities in the non-profit
and business communities consistent with Employee’s duties; and (iii) such other activities as may be specifically approved by the Board. This restriction shall not, however, preclude the Employee from owning less than one percent (1%) of the
total outstanding shares of a publicly traded company. 
 5.    NO CONFLICT
WITH EXISTING OBLIGATIONS. Employee represents that Employee’s performance of all the terms of this Agreement and as an Employee of the Company do
not and will not breach any agreement or obligation of any kind made prior to Employee’s employment by the Company, including agreements or obligations Employee may have with prior employers or entities for which Employee has provided services.
Employee has not entered into, and Employee agrees that Employee will not enter into, any agreement or obligation, either written or oral, in conflict herewith. 

6.    TERMINATION OF
EMPLOYMENT. The parties acknowledge that Employee’s employment relationship with the Company is at-will. Either Employee or the Company
may terminate the employment relationship at any time, with or without Cause. The provisions in this Section govern the amount of compensation, if any, to be provided to Employee upon termination of employment and do not alter this at-will status. 
 6.1    Termination by the Company Without Cause. 

(a)    The Company shall have the right to terminate Employee’s employment with the Company pursuant to this
Section 6.1 at any time without “Cause” (as defined in Section 6.2(a) below) by giving notice as described in Section 6.8 of this Agreement. A termination pursuant to Section 6.4 or 6.6 below is not a termination
without “Cause” for purposes of receiving the benefits described in this Section 6.1. 

  
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 (b)    In the event Employee’s employment is terminated without
Cause, then provided that the Employee executes and does not revoke a separation agreement that includes a general release substantially in the form attached hereto as Exhibit A (the “Release”), and subject to
Section 6.1(c) (the date that the Release becomes effective and may no longer be revoked by the Employee is referred to as the “Release Date”), then: 

(i)    the Company shall pay to Employee an amount equal to twelve (12) months’ of
Employee’s then current Base Salary, less applicable withholdings and deductions (the “Severance Payment”), in installments in accordance with the Company’s ordinary payroll practices commencing on the
Company’s first regular payroll date that is more than sixty (60) days following the Separation Date (as defined below), and shall be for any accrued Base Salary for the sixty (60) day period plus the period from the sixtieth (60th)
day until the regular payroll date, if applicable, and all salary continuation payments thereafter, if any, shall be made on the Company’s regular payroll dates; 

(ii)    the vesting and exercisability of all outstanding stock options and other stock awards that are held by Employee
as of immediately prior to the effective date of the Separation Date, to the extent such awards are subject to time-based vesting requirements, shall be accelerated such that 50% of the then-unvested shares shall be deemed fully vested and
exercisable as of the Separation Date; 
 (iii)    the Company shall pay to Employee a lump sum cash amount equivalent
to Employee’s Annual Bonus for the year in which the Separation Date occurs, prorated based on the number of days that Employee was employed during such performance year, divided by the total number of days in such performance year (the
“Bonus Severance Payment”). Employee’s Base Salary as in effect on the Separation Date, ignoring any decrease that forms the basis of Employee’s resignation for Good Reason, if applicable, shall be used for
calculating the Bonus Severance Payment. The Bonus Severance Payment will be paid within sixty (60) days of the effective date of the Release (namely, the date it can no longer be revoked) but in no event later than March 15 of the year
following the year in which the Separation Date occurs; and 
 (iv)    if the Employee timely elects continued coverage
under COBRA for himself and his covered dependents under the Company’s group health plans following such termination, then the Employee will be entitled to the following COBRA benefits (the “COBRA Benefits,” together
with the Severance Payment, the Bonus Severance Payment and the accelerated vesting described in Section 6.l(b)(ii), the “Severance Benefits’’): the Company shall pay the COBRA premiums necessary to continue the
Employee’s and his covered dependents’ health insurance coverage in effect for himself (and his covered dependents) on the termination date until the earliest of (x) twelve (12) months following the termination date (the
“COBRA Severance Period’’); (y) the date when the Employee becomes eligible for health insurance coverage in connection with new employment or self-employment; or (iii) the date the
Employee ceases to be eligible for COBRA continuation coverage for any reason, including plan termination (such period from the termination date through the earlier of (i)-(iii), the “COBRA Payment 

  
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Period”). Notwithstanding the foregoing, if at any time the Company determines that its payment of COBRA premiums on the Employee’s behalf would result in a violation of
applicable law (including but not limited to the 2010 Patient Protection and Affordable Care Act, as amended by the 2010 Health Care and Education Reconciliation Act), then in lieu of paying COBRA premiums pursuant to this Section, the Company shall
pay the Employee on the last day of each remaining month of the COBRA Payment Period, a fully taxable cash payment equal to the COBRA premium for such month, subject to applicable tax withholding (such amount, the “Special Severance
Payment”), such Special Severance Payment to be made without regard to the Employee’s payment of COBRA premiums and without regard to the expiration of the COBRA period prior to the end of the COBRA Payment Period. Nothing in this
Agreement shall deprive the Employee of his rights under COBRA or ERISA for benefits under plans and policies arising under his employment by the Company. 

(c)    Employee shall not receive the Severance Benefits pursuant to Section 6.1(b) unless he executes the Release
within the consideration period specified therein, which shall in no event be more than sixty (60) days, and until the Release becomes effective and can no longer be revoked by Employee under its terms. Employee’s ability to receive
benefits pursuant to Section 6.I(b) is further conditioned upon his: returning all Company property; complying with his post-termination obligations under this Agreement and the Proprietary Information Agreement; and complying with the Release
including without limitation any non-disparagement and confidentiality provisions contained therein. 
 (d)    The
benefits provided to Employee pursuant to this Section 6.1 are in lieu of, and not in addition to, any benefits to which Employee may otherwise be entitled under any Company severance plan, policy or program. 

(e)    The damages caused by the termination of Employee’s employment without Cause would be difficult to ascertain;
therefore, the severance for which Employee is eligible pursuant to Section 6.1(b) above in exchange for the Release is agreed to by the parties as liquidated damages, to serve as full compensation, and not a penalty. 

6.2    Termination by the Company for Cause. 

Subject to Section 6.2(b) below, the Company shall have the right to terminate Employee’s employment with the Company at any time for
Cause by giving notice as described in Section 6.8 of this Agreement 
 (a)    “Cause”
means (i) any material breach of this Agreement, the Proprietary Information Agreement between the Employee and the Company, or any other written agreement between Employee and the Company, if such breach causes material harm to the
Company or reasonably threatens to cause such harm; (ii) any material failure to comply with the Company’s written policies or rules, as they may be in effect from time to time during Employee’s employment, if such failure causes
material harm to the Company, and to the extent it is curable by Employee, is not cured within thirty (30) days after written notice thereof is given to Employee by the Company; (iii) commission, conviction of, or a plea of
“guilty” or “no contest” to, a felony under the laws of the United States or any State; (iv) any willful, intentional or grossly negligent act having the effect of materially injuring (whether financially or

  
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otherwise) the business or reputation of the Company, which to the extent it is curable by Employee, is not cured within thirty (30) days after written notice thereof is given to Employee by
the Company; or (v) willful misconduct with respect to any of Employee’s material duties or obligations under this Agreement, including, without limitation, willful insubordination with respect to reasonable directions from the Board
which, to the extent it is curable is not cured within thirty (30) days aft.er written notice thereof is given to Employee by the Company. 

(b)    In the event Employee’s employment is terminated at any time for Cause, Employee will not receive the
Severance Benefits described in Section 6.1(b), or any other severance compensation or benefit, except that, pursuant to the Company’s standard payroll policies, the Company shall pay to Employee the accrued but unpaid salary of Employee
through the date of termination, together with all compensation and benefits payable to Employee based on his participation in any compensation or benefit plan, program or arrangement through the date of termination. 

6.3    Resignation by the Employee With Good Reason. 

(a)    Employee may resign from Employee’s employment with the Company for Good Reason by giving notice following the
end of the Cure Period (as defined in this Section). For purposes of this Agreement, “Good Reason” for the Employee to terminate his employment hereunder shall mean the occurrence of any of the following events without the
Employee’s consent: (i) a material reduction in the Employee’s Base Salary (other than an across-the-board decrease in base salary applicable to all
executive officers of the Company); (ii) a material breach of this Agreement by the Company; (iii) a material reduction in the Employee’s duties, authority and responsibilities relative to the Employee’s duties, authority, and
responsibilities in effect immediately prior to such reduction; or (iv) the relocation of the Employee’s then-principal place of employment, without the Employee’s consent, in a manner that lengthens his
one-way commute distance by fifty (50) or more miles from his then-current principal place of employment immediately prior to such relocation; provided, however, that, any such termination by the
Employee shall only be deemed for Good Reason pursuant to this definition if: (1) the Employee gives the Company written notice of his intent to terminate for Good Reason within thirty (30) days following the first occurrence of the
condition(s) that he believes constitute(s) Good Reason, which notice shall describe such condition(s); (2) the Company fails to remedy such condition(s) within thirty (30) days following receipt of the written notice (the “Cure
Period”); and (3) the Employee voluntarily terminates his employment within thirty (30) days following the end of the Cure Period. 

(b)    In the event Employee resigns from employment for Good Reason, then provided that the Employee executes and does
not revoke the Release and subject to Section 6.1(c), then the Company shall pay to Employee the Severance Benefits described in Section 6.1(b). 

  
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 6.4    Resignation by the Employee Without Good Reason.

 (a)    Employee may resign from Employee’s employment with the Company at any time by giving notice as described
in Section 6.8. 
 (b)    In the event Employee resigns from Employee’s employment with the Company,
Employee will not receive the Severance Benefits, or any other severance compensation or benefit, except that, pursuant to the Company’s standard payroll policies, the Company shall pay to Employee the accrued but unpaid salary of Employee
through the date of resignation, together with all compensation and benefits payable to Employee through the date of resignation under any compensation or benefit plan, program or arrangement during such period and Employee shall be eligible for any
benefit continuation or conversion rights provided by the provisions of a benefit plan or by law. 

6.5    Termination Without Cause or for Good Reason Following a Change in Control. 

(a)    If Employee’s employment by the Company is terminated by the Company (or its successor or parent) without
Cause (and not due to Disability or death) or by Employee for Good Reason immediately before or within twelve (12) months immediately following a Change in Control (as defined in the Plan), that constitutes a change in control event described
in Treasury Regulation Sections 1.409A-3(i)(5), then: (x) the Company shall pay or provide Employee with the Severance Benefits described in Section 6.1(b) except that the Severance Payment described
in Section 6.1(b)(i) shall be paid to Employee in a lump sum, on the first payroll date of the Company that is at least sixty (60) days following the Separation Date; and (y) the vesting and exercisability of all outstanding stock
options and other stock awards that are held by Employee as of immediately prior to the Separation Date, to the extent such awards are subject to time-based vesting requirements, shall be accelerated (and lapse, in the case of reacquisition or
repurchase rights) in full, provided that Employee executes and does not revoke the Release. 

6.6    Termination by Virtue of Death or Disability of the Employee. 

(a)    In the event of Employee’s death while employed pursuant to this Agreement, all obligations of the parties
hereunder shall terminate immediately, and the Company shall, pursuant to the Company’s standard payroll policies, pay to the Employee’s legal representatives Employee’s accrued but unpaid salary through the date of death together
with all compensation and benefits payable to Employee based on his participation in any compensation or benefit plan, program or arrangement through the date of termination. 

(b)    Subject to applicable state and federal law, the Company shall at all times have the right, upon written notice to
the Employee, to terminate this Agreement based on the Employee’s Disability (as defined below). Termination by the Company of the Employee’s employment based on “Disability” shall mean termination because the
Employee is unable due to a physical or mental condition to perform the essential functions of his position with or without reasonable accommodation for six (6) months in the aggregate during any twelve (12) month period or based on the
written certification by two licensed physicians of the likely continuation of such condition for such period. This 

  
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definition shall be interpreted and applied consistent with the Americans with Disabilities Act, the Family and Medical Leave Act, and other applicable law. In the event Employee’s
employment is terminated based on the Employee’s Disability, Employee will not receive the Severance Benefits, or any other severance compensation or benefit, except that, pursuant to the Company’s standard payroll policies, the Company
shall pay to Employee the accrued but unpaid salary of Employee through the date of termination, together with all compensation and benefits payable to Employee based on his participation in any compensation or benefit plan, program or arrangement
through the date of termination. 
 6.7    Termination Due to Discontinuance of Business.
Anything in this Agreement to the contrary notwithstanding, in the event the Company’s business is discontinued because rendered impracticable by substantial financial losses, lack of funding, legal decisions, administrative rulings,
declaration of war, dissolution, national or local economic depression or crisis or any reasons beyond the control of the Company, then this Agreement shall terminate as of the day the Company determines to cease operation with the same force and
effect as if such day of the month were originally set as the termination date hereof. In the event this Agreement is terminated pursuant to this Section 6.7, Employee will not receive the Severance Benefits, or any other severance compensation
or benefit, except that, pursuant to the Company’s standard payroll policies, the Company shall pay to Employee the accrued but unpaid salary of Employee through the date of termination, together with all compensation and benefits payable to
Employee based on his participation in any compensation or benefit plan, program or arrangement through the date of termination. 

6.8    Notice; Effective Date of Termination. 

(a)    Termination of Employee’s employment (the “Separation Date”) pursuant to this
Agreement shall be effective on the earliest of: 
 (i)    immediately after the Company gives notice to Employee of
Employee’s termination, with or without Cause; 
 (ii)    immediately upon the Employee’s death; 

(iii)    ten ( l 0) days after the Company gives notice to Employee of Employee’s termination on account of
Employee’s Disability, unless the Company specifies a later Separation Date, in which case, termination shall be effective as of such later Separation Date,provided that Employee has not returned to the full time performance of
Employee’s duties prior to such date; 
 (iv)    immediately upon written notice by the Employee of his
resignation for Good Reason within thirty (30) days after the Cure Period has ended and the Company has failed to remedy any of the reasons for Good Reason resignation pursuant to Section 6.3(a); or 

(v)    ten (10) days after the Employee gives written notice to the Company of Employee’s resignation,
provided that the Company may set a Separation Date at 

  
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any time between the date of notice and the date of resignation, in which case the Employee’s resignation shall be effective as of such other date. Employee will receive compensation through
any required notice period. 
 (b)    In the event notice of a termination under subsections (a)(iii) and (iv) is given
orally, at the other party’s request, the party giving notice must provide written confirmation of such notice within five (5) business days of the request in compliance with the requirement of Section 7.1 below. In the event of a
termination for Cause, written confirmation shall specify the subsection(s) of the definition of Cause relied on to support the decision to terminate. 

6.9    Cooperation With Company Mter Termination of Employment. Following termination of
Employee’s employment for any reason, Employee shall reasonably cooperate with the Company in all matters relating to the winding up of Employee’s pending work including, but not limited to, any litigation in which the Company is involved,
and the orderly transfer of any such pending work to such other employees as may be designated by the Company. 

6.10    Effect of Termination. The Employee agrees that should the Employee’s employment be
terminated for any reason, the Employee shall be deemed to have resigned from any and all positions with the Company and its subsidiaries, including, but not limited, to a position on the Board. 

6.11    Application of Section 409A. Notwithstanding anything
to the contrary set forth herein, any payments and benefits provided under this Agreement that constitute “deferred compensation” within the meaning of Section 409A of the Internal Revenue Code of 1986, as amended
(“Code”) and the regulations and other guidance thereunder and any state law of similar effect (collectively, “Section 409A”) shall not commence in connection with Employee’s termination of
employment unless and until Employee has also incurred a “separation from service” (as such term is defined in Treasury Regulation Section l.409A-1(h) (“Separation From Service”),
unless the Company reasonably determines that such amounts may be provided to Employee without causing Employee to incur the additional 20% tax under Section 409A. It is intended that each installment of severance pay provided for in
this Agreement is a separate “payment” for purposes of Treasury Regulation Section 1.409A- 2(b)(2)(i). For the avoidance of doubt, it is intended that severance payments set forth in this Agreement satisfy, to the greatest extent
possible, the exceptions from the application of Section 409A provided under Treasury Regulation Sections l.409A-l(b)(4), l.409A-l(b)(5), and l.409A-l(b)(9). If the Company (or, if applicable, the successor entity thereto) determines that any payments or benefits constitute “deferred compensation” under Section 409A and Employee is, on the
termination of service, a “specified employee” of the Company or any successor entity thereto, as such term is defined in Section 409A(a)(2)(B)(i) of the Code, then, solely to the extent necessary to avoid the incurrence of the
adverse personal tax consequences under Section 409A, the timing of the payments and benefits shall be delayed until the earlier to occur of: (a) the date that is six months and one day after Employee’s Separation From Service, or
(b) the date of Employee’s death (such applicable date, the “Specified Employee Initial Payment Date’’). On the Specified Employee Initial Payment Date, the Company (or the successor
entity thereto, as applicable) shall (i) pay to Employee a lump sum amount equal to the sum of the payments and benefits that Employee would otherwise have received through the Specified Employee Initial

  
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Payment Date if the commencement of the payment of such amounts had not been so delayed pursuant to this Section and (ii) commence paying the balance of the payments and benefits in
accordance with the applicable payment schedules set forth in this Agreement. All reimbursements provided under this Agreement shall be subject to the following requirements: (i) the amount of in-kind benefits
provided or reimbursable expenses incurred in one taxable year shall not affect the in-kind benefits to be provided or the expenses eligible for reimbursement in any other taxable year, (ii) all
reimbursements shall be paid as soon as administratively practicable, but in no event shall any reimbursement be paid after the last day of the taxable year following the taxable year in which the expense was incurred, and (iii) the right to
reimbursement or in-kind benefits is not subject to liquidation or exchange for any other benefit. It is intended that all payments and benefits under this Agreement shall either comply with or be exempt from
the requirements of Section 409A, and any ambiguity contained herein shall be interpreted in such manner so as to avoid adverse personal tax consequences under Section 409A. Notwithstanding the foregoing, the Company shall in no event be
obligated to indemnify the Employee for any taxes or interest that may be assessed by the Internal Revenue Service pursuant to Section 409A of the Code to payments made pursuant to this Agreement. 

7.    GENERAL PROVISIONS. 

7.1    Notices. Any notices required hereunder to be in writing shall be deemed effectively
given: (a) upon personal delivery to the party to be notified, (b) when sent by electronic mail, telex or confirmed facsimile if sent during normal business hours of the recipient, and if not, then on the next business day, (c) five
(5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one (I) day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification
of receipt. All communications shall be sent to the Company at its primary office location and to Employee at Employee’s address as listed on the Company payroll, or at such other address as the Company or the Employee may designate by ten
(JO) days advance written notice to the other. 
 7.2    Severability. Whenever
possible, each provision of this Agreement will be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be invalid, illegal or unenforceable in any respect under any
applicable law or rule in any jurisdiction, such invalidity, illegality or unenforceability will not affect any other provision or any other jurisdiction, but this Agreement will be reformed, construed and enforced in such jurisdiction as if such
invalid, illegal or unenforceable provisions had never been contained herein. 
 7.3    Waiver.
If either party should waive any breach of any provisions of this Agreement, Employee or it shall not thereby be deemed to have waived any preceding or succeeding breach of the same or any other provision of this Agreement. 

7.4    Complete Agreement. This Agreement constitutes the entire agreement between Employee
and the Company with regard to the subject matter hereof. This Agreement is the complete, final, and exclusive embodiment of their agreement with regard to this subject matter and supersedes any prior oral discussions or written communications and
agreements. This Agreement is entered into without reliance on any promise or representation other than those expressly contained herein, and it cannot be modified or amended except in writing signed

  
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by Employee and an authorized officer of the Company. The parties have entered into a separate Proprietary Information Agreement and have or may enter into separate agreement related to stock
awards. These separate agreements govern other aspects of the relationship between the parties, have or may have provisions that survive termination of the Employee’s employment under this Agreement, may be amended or superseded by the parties
without regard to this Agreement and are enforceable according to their terms without regard to the enforcement provision of this Agreement. 

7.5    Countemarts. This Agreement may be executed in separate counterparts, any one of which
need not contain signatures of more than one party, but all of which taken together will constitute one and the same Agreement. 

7.6    Headings. The headings of the sections hereof are inserted for convenience only and
shall not be deemed to constitute a part hereof nor to affect the meaning thereof. 
 7.7    Successors and
Assigns. The Company shall assign this Agreement and its rights and obligations hereunder in whole, but not in part, to any Company or other entity with or into which the Company may hereafter merge or consolidate or to which the Company may
transfer all or substantially all of its assets, if in any such case said Company or other entity shall by operation of law or expressly in writing assume all obligations of the Company hereunder as fully as if it had been originally made a party
hereto, but may not otherwise assign this Agreement or its rights and obligations hereunder. The Employee may not assign or transfer this Agreement or any rights or obligations hereunder, other than to his estate upon his death. 

7.8    Choice of Law. All questions concerning the construction, validity and interpretation
of this Agreement will be governed by the law of the Commonwealth of Massachusetts. 

7.9    Indemnification. The Employee shall be entitled to indemnification to the maximum
extent permitted by applicable law and the Company’s Bylaws with terms no less favorable than provided to any other Company executive officer or director and subject to the terms of any separate written indemnification agreement. At all times
during the Employee’s employment, the Company shall maintain in effect a directors and officers liability insurance policy with the Employee as a covered officer. 

7.10    Resolution of Disputes. The parties recognize that litigation in federal or state
courts or before federal or state administrative agencies of disputes arising out of the Employee’s employment with the Company or out of this Agreement, or the Employee’s termination of employment or termination of this Agreement, may not
be in the best interests of either the Employee or the Company, and may result in unnecessary costs, delays, complexities, and uncertainty. The parties agree that any dispute between the parties arising out of or relating to the negotiation,
execution, performance or termination of this Agreement or the Employee’s employment, including, but not limited to, any claim arising out of this Agreement, claims under Title VII of the Civil Rights Act of 1964, as amended, the Civil Rights
Act of 1991, the Age Discrimination in Employment Act of 1967, the Americans with Disabilities Act of 1990, Section 1981 of the Civil Rights Act of 1966, as amended, the Family Medical Leave Act, the

  
 12 

 
Employee Retirement Income Security Act, and any similar federal, state or local law, statute, regulation, or any common law doctrine, whether that dispute arises during or after employment,
shall be settled by binding arbitration conducted before a single arbitrator by Judicial Arbitration and Mediation Services, Inc. (“JAMS”) or its successor, under the then applicable JAMS rules; provided however, that
this dispute resolution provision shall not apply to any separate agreements between the parties that do not themselves specify arbitration as an exclusive remedy. The location for the arbitration shall be the Boston, Massachusetts metropolitan
area. Any award made by such panel shall be final, binding and conclusive on the parties for all purposes, and judgment upon the award rendered by the arbitrators may be entered in any court having jurisdiction thereof. The arbitrators’ fees
and expenses and all administrative fees and expenses associated with the filing of the arbitration shall be borne by the Company; provided however, that at the Employee’s option, Employee may voluntarily pay up to one-half the costs and fees. The parties acknowledge and agree that their obligations to arbitrate under this Section survive the termination of this Agreement and continue after the termination of the employment
relationship between Employee and the Company. The parties each further agree that the arbitration provisions of this Agreement shall provide each party with its exclusive remedy, and each party expressly waives any right it might have to
seek redress in any other forum, except as otherwise expressly provided in this Agreement. By electing arbitration as the means for final settlement of all claims, the parties hereby waive their respective rights to, and agree not to, sue each
other in any action in a Federal, State or local court with respect to such claims, but may seek to enforce in court an arbitration award rendered pursuant to this Agreement. The parties specifically agree to waive their respective rights to
a trial by jury, and further agree that no demand, request or motion will be made for trial by jury. 
 IN WITNESS WHEREOF, the
parties have executed this Employment Agreement on the day and year first written above. 
  

			
	AVEDRO, INC.
		
	By:	 	 /s/ Gilbert Kliman

		 	Gilbert H. Kliman, M.D.
		 	Member of the Board
	
	Employee:
	
	 /s/ Reza Zadno

	Reza Zadno, Ph.D.

  
 13EX-10.10

 Exhibit 10.10 

AMENDED AND RESTATED EMPLOYMENT AGREEMENT 

This AMENDED AND RESTATED EMPLOYMENT
AGREEMENT (the “Agreement”), by and between Avedro, Inc. (the “Company”) and Reza Zadno, Ph.D. (the
“Employee”), is effective as of the date the Company consummates an initial public offering ( the “ Effective Date”). 

Between July 11, 2016 and September 23, 2016, Employee was employed as interim Chief Executive Officer (“CEO”) of the
Company, pursuant to the terms of the July 11, 2016 offer letter; 
 On September 23, 2016 the Company’s Board of Directors
(“Board’’) voted to change the Employee’s status from Interim CEO to permanent CEO and President; 

Effective as of September 23, 2016, the Employee and the Company entered into an Employment Agreement (the “Prior
Agreement”); 
 Effective as of January 1, 2017, the Board voted to increase Employee’s Base Salary as described in
Section 2.1 herein; 
 The Company desires to continue to employ the Employee in the capacity of full-time CEO and President following
the Effective Date pursuant to the terms of this Agreement, which shall amend and restate the Prior Agreement and, in connection therewith, to compensate the Employee for Employee’s personal services to the Company; and 

The Employee wishes to be employed by the Company and provide personal services to the Company in return for certain compensation. 

Accordingly, in consideration of the mutual promises and covenants contained herein, the parties agree to the following: 

1.    EMPLOYMENT BY THE COMPANY.

 1.1    At-Will Employment. Employee shall be
employed by the Company on an “at-will” basis, meaning either the Company or Employee may terminate Employee’s employment at any time, with or without cause or advanced notice. Any contrary
representations that may have been made to Employee shall be superseded by this Agreement. This Agreement shall constitute the full and complete agreement between Employee and the Company on the “at-will” nature of Employee’s
employment with the Company, which may be changed only in an express written agreement signed by Employee and a duly authorized officer of the Company. Employee’s rights to any compensation following a termination shall be only as set forth in
Section 6. 
 1.2    Position. Subject to the terms set forth herein, the Company agrees
to employ Employee, initially in the position of CEO and President and Employee hereby accepts such employment. During the term of Employee’s employment with the Company, Employee will devote Employee’s best efforts and substantially all
of Employee’s business time and attention to the business of the Company. 
 1.3    Duties.
Employee will report to the Board and/or such other Board officers, company executives and/or committees designated by the Board, performing such duties as are normally associated with his then current position and such duties as are assigned to

 him from time to time, subject to the oversight and direction of the Board. Employee shall further serve as
a Director of the Board during the term of his employment. Employee shall perform his duties under this Agreement principally out of the Company’s corporate headquarters in Massachusetts or such other location as assigned. In addition, the
Employee shall make such business trips to such places as may be necessary or advisable for the efficient operations of the Company. 

1.4    Company Policies and Benefits. The employment relationship between the parties shall
also be subject to the Company’s personnel policies and procedures as they may be interpreted, adopted, revised or deleted from time to time in the Company’s sole discretion. The Employee will be eligible to participate on the same basis
as similarly situated employees in the Company’s benefit plans in effect from time to time during his employment. All matters of eligibility for coverage or benefits under any benefit plan shall be determined in accordance with the provisions
of such plan. The Company reserves the right to change, alter, or terminate any benefit plan in its sole discretion. Notwithstanding the foregoing, in the event that the terms of this Agreement differ from or are in conflict with the Company’s
general employment policies or practices, this Agreement shall control. 
 1.5    Paid Time Off.
The Employee will be eligible to accrue up to 16 days of paid vacation and 4 personal days per calendar year, which accrues each bi-monthly pay period. In addition, the Employee will be eligible to take up
to 6 sick days per calendar year. Employee’s paid time off will be prorated based upon the Effective Date of this Agreement. 

2.    COMPENSATION. 

2.1    Salary. For the period of September 23, 2016 through December 31, 2016,
Employee shall receive for Employee’s services to be rendered hereunder an initial annualized base salary of $350,000 which shall be increased to $515,000 as of January 1, 2019 (“Base Salary”). The Base Salary is
subject to review and adjustment from time to time by the Company in its sole discretion, payable subject to standard federal and state payroll withholding requirements in accordance with Company’s standard payroll practices. 

2.2    Bonus. 

(a)    During Employment. Employee shall be eligible to earn an annual performance bonus of up to 75% of
his Base Salary (‘’Annual Bonus’’). The Annual Bonus will be based upon the Board’s assessment of the Employee’s performance and the Company’s attainment of targeted goals
as set by the Board in its sole discretion. The Annual Bonus, if any, will be subject to applicable payroll deductions and withholdings. Following the close of each calendar year, the Board will determine whether the Employee has earned the Annual
Bonus, and the amount of any Annual Bonus, based on the set criteria. No amount of the Annual Bonus is guaranteed, and the Employee must be an employee in good standing on the Annual Bonus payment date to be eligible to receive an Annual Bonus; no
partial or prorated bonuses will be provided. The Annual Bonus, if earned, will be paid no later than March 15 of the calendar year immediately following the applicable calendar year for which the Annual Bonus is being measured. The
Employee’s eligibility for an Annual Bonus is subject to change in the discretion of the Board (or any authorized committee thereof). 

  
 2 

 (b)    Upon Termination. Subject to the prov1s1ons
of Section 6.1(b)(iii), in the event Employee leaves the employ of the Company for any reason prior to payment of any bonus, he is not eligible for such bonus, prorated or otherwise. 

2.3    Equity Awards. The Employee acknowledges that as of the Effective Date, he has received the equity
awards set forth on Exhibit A hereto, under, and subject to the terms and conditions of the Company’s 2012 Equity Incentive Plan (“Plan”) and applicable award agreements thereunder. The employee acknowledges and
agrees that from and after the Effective Date, such equity awards shall only be subject to accelerated vesting in accordance with Section 6 or this Agreement. 
  

2.4    Expense Reimbursement. The Company will reimburse Employee for all reasonable,
documented business expenses incurred in connection with his services hereunder, in accordance with the Company’s business expense reimbursement policies and procedures as may be in effect from time to time. 

2.5    Home Travel Reimbursement. The Company will reimburse Employee, subject to applicable
taxes and withholdings, for reasonable travel expenses incurred in connection with Employee’s weekly travel from his home in California to the Company’s office in Massachusetts. The Company has covered the cost of a corporate apartment for
Employee’s use while at the Company’s offices in Massachusetts. Employee acknowledges that all reimbursements and/or benefits under this Section 2.5 will be taxable to Employee. The reimbursement amount payable by the Company to the
Employee pursuant to this Section 2.5 shall be “grossed up” so that on an after-tax basis the 

  
 3 

 
Company has paid to Employee, and the Employee retains, the amount otherwise payable pursuant to this Section 2.5 (i.e., the amount payable by the Company to the Employee shall equal
x divided by (y minus z) where (i) x is the amount of the reimbursement payment described above, (ii) y is equal to one and (iii) z is the federal and state blended tax rate applicable to such payment). 

3.    PROPRIETARY INFORMATION, INVENTIONS, NON-COMPETITION AND NON-SOLICITATION OBLIGATIONS.
The parties hereto have entered into a Proprietary Information, Inventions, Non-Competition and Non-Solicitation Agreement (the “Proprietary
Information Agreement”), which may be amended by the parties from time to time without regard to this Agreement. The Proprietary Information Agreement contains provisions that are intended by the parties to
survive and do survive termination or expiration of this Agreement. 
 4.    OUTSIDE
ACTIVITIES. Except with the prior written consent of the Company’s Board, Employee will not, while employed by the Company, undertake or engage in any other employment,
occupation or business enterprise that would interfere with Employee’s responsibilities and the performance of Employee’s duties hereunder except for (i) reasonable time devoted to volunteer services for or on behalf of such
religious, educational, non-profit and/or other charitable organization as Employee may wish to serve; (ii) reasonable time devoted to activities in the non-profit
and business communities consistent with Employee’s duties; and (iii) such other activities as may be specifically approved by the Board. This restriction shall not, however, preclude the Employee from owning less than one percent (1%) of the
total outstanding shares of a publicly traded company. 
 5.    NO CONFLICT
WITH EXISTING OBLIGATIONS. Employee represents that Employee’s performance of all the terms of this Agreement and as an Employee of the Company do
not and will not breach any agreement or obligation of any kind made prior to Employee’s employment by the Company, including agreements or obligations Employee may have with prior employers or entities for which Employee has provided services.
Employee has not entered into, and Employee agrees that Employee will not enter into, any agreement or obligation, either written or oral, in conflict herewith. 

6.    TERMINATION OF
EMPLOYMENT. The parties acknowledge that Employee’s employment relationship with the Company is at-will. Either Employee or the Company
may terminate the employment relationship at any time, with or without Cause. The provisions in this Section govern the amount of compensation, if any, to be provided to Employee upon termination of employment and do not alter this at-will status. 
 6.1    Termination by the Company Without Cause. 

(a)    The Company shall have the right to terminate Employee’s employment with the Company pursuant to this
Section 6.1 at any time without “Cause” (as defined in Section 6.2(a) below) by giving notice as described in Section 6.8 of this Agreement. A termination pursuant to Section 6.4 or 6.6 below is not a termination
without “Cause” for purposes of receiving the benefits described in this Section 6.1. 

  
 4 

 (b)    In the event Employee’s employment is terminated without
Cause, then provided that the Employee executes and does not revoke a separation agreement that includes a general release substantially in the form attached hereto as Exhibit B (the “Release”), and subject to
Section 6.1(c) (the date that the Release becomes effective and may no longer be revoked by the Employee is referred to as the “Release Date”), then: 

(i)    the Company shall pay to Employee an amount equal to twelve (12) months’ of
Employee’s then current Base Salary, less applicable withholdings and deductions (the “Severance Payment”), in installments in accordance with the Company’s ordinary payroll practices commencing on the
Company’s first regular payroll date that is more than sixty (60) days following the Separation Date (as defined below), and shall be for any accrued Base Salary for the sixty (60) day period plus the period from the sixtieth (60th)
day until the regular payroll date, if applicable, and all salary continuation payments thereafter, if any, shall be made on the Company’s regular payroll dates; 

(ii)    the vesting and exercisability of all outstanding stock options and other stock awards that are held by Employee
as of immediately prior to the effective date of the Separation Date, to the extent such awards are subject to time-based vesting requirements, shall be accelerated such that 50% of the then-unvested shares shall be deemed fully vested and
exercisable as of the Separation Date; 
 (iii)    the Company shall pay to Employee a lump sum cash amount equivalent
to Employee’s Annual Bonus for the year in which the Separation Date occurs, prorated based on the number of days that Employee was employed during such performance year, divided by the total number of days in such performance year (the
“Bonus Severance Payment”). Employee’s Base Salary as in effect on the Separation Date, ignoring any decrease that forms the basis of Employee’s resignation for Good Reason, if applicable, shall be used for
calculating the Bonus Severance Payment. The Bonus Severance Payment will be paid within sixty (60) days of the effective date of the Release (namely, the date it can no longer be revoked) but in no event later than March 15 of the year
following the year in which the Separation Date occurs; and 
 (iv)    if the Employee timely elects continued coverage
under COBRA for himself and his covered dependents under the Company’s group health plans following such termination, then the Employee will be entitled to the following COBRA benefits (the “COBRA Benefits,” together
with the Severance Payment, the Bonus Severance Payment and the accelerated vesting described in Section 6.l(b)(ii), the “Severance Benefits’’): the Company shall pay the COBRA premiums necessary to continue the
Employee’s and his covered dependents’ health insurance coverage in effect for himself (and his covered dependents) on the termination date until the earliest of (x) twelve (12) months following the termination date (the
“COBRA Severance Period’’); (y) the date when the Employee becomes eligible for health insurance coverage in connection with new employment or self-employment; or (iii) the date the
Employee ceases to be eligible for COBRA continuation coverage for any reason, including plan termination (such period from the termination date through the earlier of (i)-(iii), the “COBRA Payment 

  
 5 

 
Period”). Notwithstanding the foregoing, if at any time the Company determines that its payment of COBRA premiums on the Employee’s behalf would result in a violation of
applicable law (including but not limited to the 2010 Patient Protection and Affordable Care Act, as amended by the 2010 Health Care and Education Reconciliation Act), then in lieu of paying COBRA premiums pursuant to this Section, the Company shall
pay the Employee on the last day of each remaining month of the COBRA Payment Period, a fully taxable cash payment equal to the COBRA premium for such month, subject to applicable tax withholding (such amount, the “Special Severance
Payment”), such Special Severance Payment to be made without regard to the Employee’s payment of COBRA premiums and without regard to the expiration of the COBRA period prior to the end of the COBRA Payment Period. Nothing in this
Agreement shall deprive the Employee of his rights under COBRA or ERISA for benefits under plans and policies arising under his employment by the Company. 

(c)    Employee shall not receive the Severance Benefits pursuant to Section 6.1(b) unless he executes the Release
within the consideration period specified therein, which shall in no event be more than sixty (60) days, and until the Release becomes effective and can no longer be revoked by Employee under its terms. Employee’s ability to receive
benefits pursuant to Section 6.I(b) is further conditioned upon his: returning all Company property; complying with his post-termination obligations under this Agreement and the Proprietary Information Agreement; and complying with the Release
including without limitation any non-disparagement and confidentiality provisions contained therein. 
 (d)    The
benefits provided to Employee pursuant to this Section 6.1 are in lieu of, and not in addition to, any benefits to which Employee may otherwise be entitled under any Company severance plan, policy or program. 

(e)    The damages caused by the termination of Employee’s employment without Cause would be difficult to ascertain;
therefore, the severance for which Employee is eligible pursuant to Section 6.1(b) above in exchange for the Release is agreed to by the parties as liquidated damages, to serve as full compensation, and not a penalty. 

6.2    Termination by the Company for Cause. 

Subject to Section 6.2(b) below, the Company shall have the right to terminate Employee’s employment with the Company at any time for
Cause by giving notice as described in Section 6.8 of this Agreement 
 (a)    “Cause”
means (i) any material breach of this Agreement, the Proprietary Information Agreement between the Employee and the Company, or any other written agreement between Employee and the Company, if such breach causes material harm to the
Company or reasonably threatens to cause such harm; (ii) any material failure to comply with the Company’s written policies or rules, as they may be in effect from time to time during Employee’s employment, if such failure causes
material harm to the Company, and to the extent it is curable by Employee, is not cured within thirty (30) days after written notice thereof is given to Employee by the Company; (iii) commission, conviction of, or a plea of
“guilty” or “no contest” to, a felony under the laws of the United States or any State; (iv) any willful, intentional or grossly negligent act having the effect of materially injuring (whether financially or

  
 6 

 
otherwise) the business or reputation of the Company, which to the extent it is curable by Employee, is not cured within thirty (30) days after written notice thereof is given to Employee by
the Company; or (v) willful misconduct with respect to any of Employee’s material duties or obligations under this Agreement, including, without limitation, willful insubordination with respect to reasonable directions from the Board
which, to the extent it is curable is not cured within thirty (30) days aft.er written notice thereof is given to Employee by the Company. 

(b)    In the event Employee’s employment is terminated at any time for Cause, Employee will not receive the
Severance Benefits described in Section 6.1(b), or any other severance compensation or benefit, except that, pursuant to the Company’s standard payroll policies, the Company shall pay to Employee the accrued but unpaid salary of Employee
through the date of termination, together with all compensation and benefits payable to Employee based on his participation in any compensation or benefit plan, program or arrangement through the date of termination. 

6.3    Resignation by the Employee With Good Reason. 

(a)    Employee may resign from Employee’s employment with the Company for Good Reason by giving notice following the
end of the Cure Period (as defined in this Section). For purposes of this Agreement, “Good Reason” for the Employee to terminate his employment hereunder shall mean the occurrence of any of the following events without the
Employee’s consent: (i) a material reduction in the Employee’s Base Salary (other than an across-the-board decrease in base salary applicable to all
executive officers of the Company); (ii) a material breach of this Agreement by the Company; (iii) a material reduction in the Employee’s duties, authority and responsibilities relative to the Employee’s duties, authority, and
responsibilities in effect immediately prior to such reduction; or (iv) the relocation of the Employee’s then-principal place of employment, without the Employee’s consent, in a manner that lengthens his
one-way commute distance by fifty (50) or more miles from his then-current principal place of employment immediately prior to such relocation; provided, however, that, any such termination by the
Employee shall only be deemed for Good Reason pursuant to this definition if: (1) the Employee gives the Company written notice of his intent to terminate for Good Reason within thirty (30) days following the first occurrence of the
condition(s) that he believes constitute(s) Good Reason, which notice shall describe such condition(s); (2) the Company fails to remedy such condition(s) within thirty (30) days following receipt of the written notice (the “Cure
Period”); and (3) the Employee voluntarily terminates his employment within thirty (30) days following the end of the Cure Period. 

(b)    In the event Employee resigns from employment for Good Reason, then provided that the Employee executes and does
not revoke the Release and subject to Section 6.1(c), then the Company shall pay to Employee the Severance Benefits described in Section 6.1(b). 

  
 7 

 6.4    Resignation by the Employee Without Good Reason.

 (a)    Employee may resign from Employee’s employment with the Company at any time by giving notice as described
in Section 6.8. 
 (b)    In the event Employee resigns from Employee’s employment with the Company,
Employee will not receive the Severance Benefits, or any other severance compensation or benefit, except that, pursuant to the Company’s standard payroll policies, the Company shall pay to Employee the accrued but unpaid salary of Employee
through the date of resignation, together with all compensation and benefits payable to Employee through the date of resignation under any compensation or benefit plan, program or arrangement during such period and Employee shall be eligible for any
benefit continuation or conversion rights provided by the provisions of a benefit plan or by law. 

6.5    Termination Without Cause or for Good Reason Following a Change in Control. 

(a)    If Employee’s employment by the Company is terminated by the Company (or its successor or parent) without
Cause (and not due to Disability or death) or by Employee for Good Reason immediately before or within eighteen (18) months immediately following a Change in Control (as defined in the Plan), that constitutes a change in control event described
in Treasury Regulation Sections 1.409A-3(i)(5), then: (x) (1) the Severance Payment shall equal (A) an amount equal to eighteen (18) months of Employee’s then current base salary, plus (B) one and
one-half (11/2) times Employee’s target Annual Bonus for the year of termination and (2) the COBRA Severance Period shall be up to eighteen (18) months following the termination date;
(y) the Company shall pay or provide Employee with the Severance Benefits described in Section 6.1(b) (as increased by (x), above) except that such Severance Payment shall be paid to Employee in a lump sum, on the first payroll date of the
Company that is at least sixty (60) days following the Separation Date; and (z) the vesting and exercisability of all outstanding stock options and other stock awards that are held by Employee as of immediately prior to the Separation
Date, to the extent such awards are subject to time-based vesting requirements, shall be accelerated (and lapse, in the case of reacquisition or repurchase rights) in full, provided that Employee executes and does not revoke the Release. 

6.6    Termination by Virtue of Death or Disability of the Employee. 

(a)    In the event of Employee’s death while employed pursuant to this Agreement, all obligations of the parties
hereunder shall terminate immediately, and the Company shall, pursuant to the Company’s standard payroll policies, pay to the Employee’s legal representatives Employee’s accrued but unpaid salary through the date of death together
with all compensation and benefits payable to Employee based on his participation in any compensation or benefit plan, program or arrangement through the date of termination. 

(b)    Subject to applicable state and federal law, the Company shall at all times have the right, upon written notice to
the Employee, to terminate this Agreement based on the Employee’s Disability (as defined below). Termination by the Company of the Employee’s employment based on “Disability” shall mean termination because the
Employee is unable due to a physical or mental condition to perform the essential functions of his position with or without reasonable accommodation for six (6) months in the aggregate during any twelve (12) month period or based on the
written certification by two licensed physicians of the likely continuation of such condition for such period. This 

  
 8 

 
definition shall be interpreted and applied consistent with the Americans with Disabilities Act, the Family and Medical Leave Act, and other applicable law. In the event Employee’s
employment is terminated based on the Employee’s Disability, Employee will not receive the Severance Benefits, or any other severance compensation or benefit, except that, pursuant to the Company’s standard payroll policies, the Company
shall pay to Employee the accrued but unpaid salary of Employee through the date of termination, together with all compensation and benefits payable to Employee based on his participation in any compensation or benefit plan, program or arrangement
through the date of termination. 
 6.7    Termination Due to Discontinuance of Business.
Anything in this Agreement to the contrary notwithstanding, in the event the Company’s business is discontinued because rendered impracticable by substantial financial losses, lack of funding, legal decisions, administrative rulings,
declaration of war, dissolution, national or local economic depression or crisis or any reasons beyond the control of the Company, then this Agreement shall terminate as of the day the Company determines to cease operation with the same force and
effect as if such day of the month were originally set as the termination date hereof. In the event this Agreement is terminated pursuant to this Section 6.7, Employee will not receive the Severance Benefits, or any other severance compensation
or benefit, except that, pursuant to the Company’s standard payroll policies, the Company shall pay to Employee the accrued but unpaid salary of Employee through the date of termination, together with all compensation and benefits payable to
Employee based on his participation in any compensation or benefit plan, program or arrangement through the date of termination. 

6.8    Notice; Effective Date of Termination. 

(a)    Termination of Employee’s employment (the “Separation Date”) pursuant to this
Agreement shall be effective on the earliest of: 
 (i)    immediately after the Company gives notice to Employee of
Employee’s termination, with or without Cause; 
 (ii)    immediately upon the Employee’s death; 

(iii)    ten ( l 0) days after the Company gives notice to Employee of Employee’s termination on account of
Employee’s Disability, unless the Company specifies a later Separation Date, in which case, termination shall be effective as of such later Separation Date,provided that Employee has not returned to the full time performance of
Employee’s duties prior to such date; 
 (iv)    immediately upon written notice by the Employee of his
resignation for Good Reason within thirty (30) days after the Cure Period has ended and the Company has failed to remedy any of the reasons for Good Reason resignation pursuant to Section 6.3(a); or 

(v)    ten (10) days after the Employee gives written notice to the Company of Employee’s resignation,
provided that the Company may set a Separation Date at 

  
 9 

 
any time between the date of notice and the date of resignation, in which case the Employee’s resignation shall be effective as of such other date. Employee will receive compensation through
any required notice period. 
 (b)    In the event notice of a termination under subsections (a)(iii) and (iv) is given
orally, at the other party’s request, the party giving notice must provide written confirmation of such notice within five (5) business days of the request in compliance with the requirement of Section 7.1 below. In the event of a
termination for Cause, written confirmation shall specify the subsection(s) of the definition of Cause relied on to support the decision to terminate. 

6.9    Cooperation With Company Mter Termination of Employment. Following termination of
Employee’s employment for any reason, Employee shall reasonably cooperate with the Company in all matters relating to the winding up of Employee’s pending work including, but not limited to, any litigation in which the Company is involved,
and the orderly transfer of any such pending work to such other employees as may be designated by the Company. 

6.10    Effect of Termination. The Employee agrees that should the Employee’s employment be
terminated for any reason, the Employee shall be deemed to have resigned from any and all positions with the Company and its subsidiaries, including, but not limited, to a position on the Board. 

6.11    Application of Section 409A. Notwithstanding anything
to the contrary set forth herein, any payments and benefits provided under this Agreement that constitute “deferred compensation” within the meaning of Section 409A of the Internal Revenue Code of 1986, as amended
(“Code”) and the regulations and other guidance thereunder and any state law of similar effect (collectively, “Section 409A”) shall not commence in connection with Employee’s termination of
employment unless and until Employee has also incurred a “separation from service” (as such term is defined in Treasury Regulation Section l.409A-1(h) (“Separation From Service”),
unless the Company reasonably determines that such amounts may be provided to Employee without causing Employee to incur the additional 20% tax under Section 409A. It is intended that each installment of severance pay provided for in
this Agreement is a separate “payment” for purposes of Treasury Regulation Section 1.409A- 2(b)(2)(i). For the avoidance of doubt, it is intended that severance payments set forth in this Agreement satisfy, to the greatest extent
possible, the exceptions from the application of Section 409A provided under Treasury Regulation Sections l.409A-l(b)(4), l.409A-l(b)(5), and l.409A-l(b)(9). If the Company (or, if applicable, the successor entity thereto) determines that any payments or benefits constitute “deferred compensation” under Section 409A and Employee is, on the
termination of service, a “specified employee” of the Company or any successor entity thereto, as such term is defined in Section 409A(a)(2)(B)(i) of the Code, then, solely to the extent necessary to avoid the incurrence of the
adverse personal tax consequences under Section 409A, the timing of the payments and benefits shall be delayed until the earlier to occur of: (a) the date that is six months and one day after Employee’s Separation From Service, or
(b) the date of Employee’s death (such applicable date, the “Specified Employee Initial Payment Date’’). On the Specified Employee Initial Payment Date, the Company (or the successor
entity thereto, as applicable) shall (i) pay to Employee a lump sum amount equal to the sum of the payments and benefits that Employee would otherwise have received through the Specified Employee Initial

  
 10 

 
Payment Date if the commencement of the payment of such amounts had not been so delayed pursuant to this Section and (ii) commence paying the balance of the payments and benefits in
accordance with the applicable payment schedules set forth in this Agreement. All reimbursements provided under this Agreement shall be subject to the following requirements: (i) the amount of in-kind benefits
provided or reimbursable expenses incurred in one taxable year shall not affect the in-kind benefits to be provided or the expenses eligible for reimbursement in any other taxable year, (ii) all
reimbursements shall be paid as soon as administratively practicable, but in no event shall any reimbursement be paid after the last day of the taxable year following the taxable year in which the expense was incurred, and (iii) the right to
reimbursement or in-kind benefits is not subject to liquidation or exchange for any other benefit. It is intended that all payments and benefits under this Agreement shall either comply with or be exempt from
the requirements of Section 409A, and any ambiguity contained herein shall be interpreted in such manner so as to avoid adverse personal tax consequences under Section 409A. Notwithstanding the foregoing, the Company shall in no event be
obligated to indemnify the Employee for any taxes or interest that may be assessed by the Internal Revenue Service pursuant to Section 409A of the Code to payments made pursuant to this Agreement. 

7.    GENERAL PROVISIONS. 

7.1    Notices. Any notices required hereunder to be in writing shall be deemed effectively
given: (a) upon personal delivery to the party to be notified, (b) when sent by electronic mail, telex or confirmed facsimile if sent during normal business hours of the recipient, and if not, then on the next business day, (c) five
(5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one (I) day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification
of receipt. All communications shall be sent to the Company at its primary office location and to Employee at Employee’s address as listed on the Company payroll, or at such other address as the Company or the Employee may designate by ten
(JO) days advance written notice to the other. 
 7.2    Severability. Whenever
possible, each provision of this Agreement will be interpreted in such manner as to be effective and valid under applicable law, but if any provision of this Agreement is held to be invalid, illegal or unenforceable in any respect under any
applicable law or rule in any jurisdiction, such invalidity, illegality or unenforceability will not affect any other provision or any other jurisdiction, but this Agreement will be reformed, construed and enforced in such jurisdiction as if such
invalid, illegal or unenforceable provisions had never been contained herein. 
 7.3    Waiver.
If either party should waive any breach of any provisions of this Agreement, Employee or it shall not thereby be deemed to have waived any preceding or succeeding breach of the same or any other provision of this Agreement. 

7.4    Complete Agreement. This Agreement constitutes the entire agreement between Employee
and the Company with regard to the subject matter hereof. This Agreement is the complete, final, and exclusive embodiment of their agreement with regard to this subject matter and supersedes any prior oral discussions or written communications and
agreements. This Agreement is entered into without reliance on any promise or representation other than those expressly contained herein, and it cannot be modified or amended except in writing signed

  
 11 

 
by Employee and an authorized officer of the Company. The parties have entered into a separate Proprietary Information Agreement and have or may enter into separate agreement related to stock
awards. These separate agreements govern other aspects of the relationship between the parties, have or may have provisions that survive termination of the Employee’s employment under this Agreement, may be amended or superseded by the parties
without regard to this Agreement and are enforceable according to their terms without regard to the enforcement provision of this Agreement. 

7.5    Countemarts. This Agreement may be executed in separate counterparts, any one of which
need not contain signatures of more than one party, but all of which taken together will constitute one and the same Agreement. 

7.6    Headings. The headings of the sections hereof are inserted for convenience only and
shall not be deemed to constitute a part hereof nor to affect the meaning thereof. 
 7.7    Successors and
Assigns. The Company shall assign this Agreement and its rights and obligations hereunder in whole, but not in part, to any Company or other entity with or into which the Company may hereafter merge or consolidate or to which the Company may
transfer all or substantially all of its assets, if in any such case said Company or other entity shall by operation of law or expressly in writing assume all obligations of the Company hereunder as fully as if it had been originally made a party
hereto, but may not otherwise assign this Agreement or its rights and obligations hereunder. The Employee may not assign or transfer this Agreement or any rights or obligations hereunder, other than to his estate upon his death. 

7.8    Choice of Law. All questions concerning the construction, validity and interpretation
of this Agreement will be governed by the law of the Commonwealth of Massachusetts. 

7.9    Indemnification. The Employee shall be entitled to indemnification to the maximum
extent permitted by applicable law and the Company’s Bylaws with terms no less favorable than provided to any other Company executive officer or director and subject to the terms of any separate written indemnification agreement. At all times
during the Employee’s employment, the Company shall maintain in effect a directors and officers liability insurance policy with the Employee as a covered officer. 

7.10    Resolution of Disputes. The parties recognize that litigation in federal or state
courts or before federal or state administrative agencies of disputes arising out of the Employee’s employment with the Company or out of this Agreement, or the Employee’s termination of employment or termination of this Agreement, may not
be in the best interests of either the Employee or the Company, and may result in unnecessary costs, delays, complexities, and uncertainty. The parties agree that any dispute between the parties arising out of or relating to the negotiation,
execution, performance or termination of this Agreement or the Employee’s employment, including, but not limited to, any claim arising out of this Agreement, claims under Title VII of the Civil Rights Act of 1964, as amended, the Civil Rights
Act of 1991, the Age Discrimination in Employment Act of 1967, the Americans with Disabilities Act of 1990, Section 1981 of the Civil Rights Act of 1966, as amended, the Family Medical Leave Act, the

  
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Employee Retirement Income Security Act, and any similar federal, state or local law, statute, regulation, or any common law doctrine, whether that dispute arises during or after employment,
shall be settled by binding arbitration conducted before a single arbitrator by Judicial Arbitration and Mediation Services, Inc. (“JAMS”) or its successor, under the then applicable JAMS rules; provided however, that
this dispute resolution provision shall not apply to any separate agreements between the parties that do not themselves specify arbitration as an exclusive remedy. The location for the arbitration shall be the Boston, Massachusetts metropolitan
area. Any award made by such panel shall be final, binding and conclusive on the parties for all purposes, and judgment upon the award rendered by the arbitrators may be entered in any court having jurisdiction thereof. The arbitrators’ fees
and expenses and all administrative fees and expenses associated with the filing of the arbitration shall be borne by the Company; provided however, that at the Employee’s option, Employee may voluntarily pay up to one-half the costs and fees. The parties acknowledge and agree that their obligations to arbitrate under this Section survive the termination of this Agreement and continue after the termination of the employment
relationship between Employee and the Company. The parties each further agree that the arbitration provisions of this Agreement shall provide each party with its exclusive remedy, and each party expressly waives any right it might have to
seek redress in any other forum, except as otherwise expressly provided in this Agreement. By electing arbitration as the means for final settlement of all claims, the parties hereby waive their respective rights to, and agree not to, sue each
other in any action in a Federal, State or local court with respect to such claims, but may seek to enforce in court an arbitration award rendered pursuant to this Agreement. The parties specifically agree to waive their respective rights to
a trial by jury, and further agree that no demand, request or motion will be made for trial by jury. 
 IN WITNESS WHEREOF, the
parties have executed this Employment Agreement on the day and year first written above. 
  

			
	AVEDRO, INC.
		
	By:	 	 /s/ Gilbert H. Kliman

		 	Gilbert H. Kliman, M.D.
		 	Member of the Board
	
	Employee:
	
	 /s/ Reza Zadno

	Reza Zadno, Ph.D.

  
 13 

 Exhibit A 
  

							
	 Grant Date
	  	 Type of Award
	  	
Number of Shares
subject to Award
	  	 Exercise Price

	January 9, 2019	  	ISO	  	1,190,000	  	$2.86
	January 31, 2018	  	RSU	  	74,860	  	$0.00
	January 31, 2018	  	ISO	  	2,339,285	  	$0.48
	July 18, 2018	  	ISO	  	893,650	  	$0.83

  
 14

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