Document:

SUPPLEMENTAL INDENTURE, DATED AS OF AUGUST 2, 2004

 Exhibit 4.4 
  
 SUPPLEMENTAL INDENTURE 
  

This Supplemental Indenture, dated as of August 2, 2004 (this “Supplemental Indenture”), is made by and among Fisher Scientific
International Inc., a Delaware corporation (“Fisher”), Apogent Technologies Inc., a Wisconsin corporation (the “Company”), and The Bank of New York, a New York banking corporation, as trustee (the
“Trustee”) under the Indenture referred to below. 
  
 W I T N E S S E T H: 
  
 WHEREAS,
the Company and the Trustee are parties to an Indenture, dated as of December 17, 2003 (as amended, supplemented, waived or otherwise modified, the “Indenture”), providing for the issuance of an aggregate principal amount of $345
million of Floating Rate Senior Convertible Contingent Debt Securities (CODES) due 2033 of the Company (the “Securities”); 
  
 WHEREAS, Section 12.4 of the Indenture provides that, upon any merger of the Company with another corporation as a result of which holders of the common
stock, par value $0.01 per share of the Company (the “Apogent Common Stock”) shall be entitled to receive stock, securities or other property or assets (including cash) with respect to or in exchange for such Apogent Common Stock (a
“Qualifying Merger”), the Company must execute with the Trustee a supplemental indenture providing that the Securities will be convertible into the kind and amount of shares of stock and other securities or property or assets which
a Holder (as defined in the Indenture) of the Securities would have been entitled to receive upon the Qualifying Merger had the Securities been converted into Apogent Common Stock immediately prior to the Qualifying Merger, and that such
supplemental indenture shall provide for adjustments that shall be as nearly equivalent as may be practicable to the adjustments provided for in Article 12 of the Indenture; 
  
 WHEREAS, Section 12.4 of the Indenture also provides that if the stock or other securities and assets receivable thereupon
by a holder of Apogent Common Stock in the Qualifying Merger includes shares of stock or other securities and assets of a corporation other than the Company in such Qualifying Merger, then such supplemental indenture shall also be executed by such
other corporation and shall contain such additional provisions to protect the interests of the Holders of the Securities as the Board of Directors of the Company shall reasonably consider necessary by reason of the foregoing, including to the extent
practicable the provisions providing for the repurchase rights set forth in Article 11 of the Indenture; 
  
 WHEREAS, pursuant to the Agreement and Plan of Merger, dated as of March 17, 2004, as amended on April 16, 2004, by and among Fisher, Fox Merger
Corporation, a Wisconsin corporation and a direct, wholly-owned subsidiary of Fisher (“Merger Sub”) and Apogent, Merger Sub merged with and into the Company and the Company became a direct, wholly-owned subsidiary of Fisher (the
“Merger”), effective as of 12 p.m.(Eastern time) on the date hereof (the “Effective Time”); 

 WHEREAS, in connection with the Merger, each outstanding share of the Apogent Common Stock was converted
into a right to receive 0.56 shares of the common stock, par value $0.01 per share of Fisher (the “Fisher Common Stock”); and 
  
 WHEREAS, pursuant to Section 7.1 of the Indenture, the Trustee and the Company are authorized to execute and deliver a supplemental indenture to amend the
Indenture without the consent of any Holder, (a) to provide for conversion rights of Holders of Securities in the event of a Qualifying Merger or similar transaction, and (b) to cure any ambiguity, to correct or supplement any provision in the
Indenture which may be inconsistent with any other provision in the Indenture or which is otherwise defective, or to make any other provisions with respect to matters or questions arising under the Indenture which the Company may deem necessary or
desirable and which shall not be inconsistent with the provisions of the Indenture; provided, however, that such action does not, in the good faith opinion of the Board of Directors of the Company and the Trustee, adversely affect the
interests of the Holders of Securities in any material respect. 
  
 NOW, THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt of which is hereby acknowledged, Fisher, the Company and the Trustee mutually covenant and agree for the equal and ratable benefit
of the Holders of the Securities as follows: 
  
 ARTICLE I 

  
 Definitions 
  
 SECTION 1.1. Terms Used in this Supplemental Indenture. As used in
this Supplemental Indenture, terms defined in the Indenture or in the preamble or recital thereto are used herein as therein defined. The words “herein,” “hereof” and “hereby” and other words of similar import used in
this Supplemental Indenture refer to this Supplemental Indenture as a whole and not to any particular section hereof. 
  
 SECTION 1.2. Restatement of Certain Definitions in the Indenture. The following definitions in Section 1.1 of the Indenture are hereby amended and
restated as follows: 
  
 “Adjusted
Spread” means, with respect to any Reset Transaction, the arithmetic average of the spreads, expressed as a percentage, from 3-month LIBOR quoted by two Reference Dealers as the spread from 3-month LIBOR which should be used in calculating
the rate at which the Interest Rate on the CODES should accrue so that the Fair Market Value, expressed in dollars, of a CODES immediately after the later of: 
  

(a) the public announcement of the Reset Transaction; or 
  
 (b) the public announcement of a change in dividend policy in connection with the Reset Transaction,

  
 will equal the average Trading Price of the CODES for the 20
Trading Days preceding the date of public announcement of the Reset Transaction or the change in dividend policy, as the case may be; provided that, in no event will the Interest Rate borne by the 
  

 2 

 CODES (without giving effect to any Contingent Interest) at any time after the first Interest Payment
Date be less than the greater of (a) zero and (b) 3-month LIBOR, determined by the Calculation Agent in accordance with the Security attached as Annex A hereto, minus 125 basis points. 
  
 “Board of Directors” means either the board of directors of the Company or Fisher, as
applicable, or any committee of that board empowered to act for it with respect to this Indenture. 
  
 “Board Resolution” means a resolution duly adopted by the applicable Board of Directors, a copy of which, certified by
the Secretary or an Assistant Secretary of the Company or Fisher, as applicable, to be in full force and effect on the date of such certification, shall have been delivered to the Trustee. 
  
 “Change of Control” means the occurrence of
any of the following after the original issuance of the Securities when any of the following has occurred:  
  
 (1) the acquisition by any “person”, including any syndicate or group deemed to be a “person” under Section 13(d)(3)
of the Exchange Act, as amended, of beneficial ownership, directly or indirectly, through a purchase, merger or other acquisition transaction or series of purchase, merger or other acquisition transactions of shares of Fisher’s or the
Company’s Capital Stock entitling such person to exercise 50% or more of the total voting power of all shares of such company’s Capital Stock entitled to vote generally in elections of directors, other than any acquisition by Fisher, any
of its Subsidiaries or any of its employee benefit plans (except that such person shall be deemed to have beneficial ownership of all securities that such person has the right to acquire, whether such right is currently exercisable or is exercisable
only upon the occurrence of a subsequent condition); 
  
 (2) the first day on which a majority of the members of the Board of Directors of Fisher are not Continuing Directors; or 
  
 (3) any consolidation or merger of Fisher or the Company with or into any other person (which for purposes of this definition has the
meaning set forth in Section 13(d)(3) of the Exchange Act), any merger of another person into Fisher or the Company, or any conveyance, transfer, sale, lease or other disposition of all or substantially all of the properties and assets of Fisher or
the Company to another person, other than, in each case, (x) any transaction (i) that does not result in any reclassification, conversion, exchange or cancellation of outstanding shares of Capital Stock of Fisher or the Company, as applicable and
(ii) pursuant to which holders of Capital Stock of Fisher or the Company, as applicable, immediately prior to such transaction have the entitlement to exercise, directly or indirectly, 50% or more of the total voting power of all shares of the
Capital Stock of such company entitled to vote generally in the election of directors of the continuing or surviving person immediately after such transaction, (y) any such merger solely for the purpose of changing the jurisdiction of incorporation
of 
  

 3 

 Fisher or the Company, as applicable, and resulting in a reclassification, conversion or exchange of
outstanding common stock of such company solely into shares of the common stock of the surviving entity, or (z) any such consolidation or merger of Fisher or the Company with or into any Fisher Subsidiary, any merger of any Fisher Subsidiary into
Fisher or the Company, or any conveyance, transfer, sale, lease or other disposition of all or substantially all of the properties and assets of Fisher or the Company to any Fisher Subsidiary; 
  
 provided, however, that a Change of Control shall not be deemed to
have occurred if the Sale Price per share of Common Stock for any five Trading Days within the period of 10 consecutive Trading Days ending immediately after the later of the Change of Control or the public announcement of the Change of Control, in
the case of a Change of Control under clause (1) above, or the period of 10 consecutive Trading Days ending immediately before the Change of Control, in the case of a Change of Control under clause (2) above, shall equal or exceed 110% of the
Conversion Price of the CODES in effect on each such Trading Day or at least 90% of the consideration in the transaction or transactions constituting a Change of Control consists of shares of common stock traded or to be traded immediately following
such Change of Control on a national securities exchange or the Nasdaq National Market and, as a result of the transaction or transactions, the CODES become convertible solely into such common stock (and any rights attached thereto).

  
 For the purposes of this definition,
“beneficial ownership” shall be determined in accordance with Rule 13d-3 under the Exchange Act. 
  
 “Common Stock” means any stock of any class of Fisher which has no preference in respect of dividends or of amounts
payable in the event of any voluntary or involuntary liquidation, dissolution or winding up of Fisher and which is not subject to redemption by Fisher. However, subject to the provisions of Section 12.2 hereof, shares issuable on conversion of the
CODES shall include only shares of the class designated as Common Stock, par value $.01 per share, of Fisher at the date of execution of the Supplemental Indenture dated August 2, 2004, by and among the Company, Fisher and the Trustee or shares of
any class or classes resulting from any reclassification or reclassifications thereof and which have no preference in respect of dividends or of amounts payable in the event of any voluntary or involuntary liquidation, dissolution or winding up of
Fisher and which are not subject to redemption by Fisher, provided that if at any time there shall be more than one such resulting class, the shares of each such class then so issuable shall be substantially in the proportion which the total
number of shares of such class resulting from all such reclassifications bears to the total number of shares of all such classes resulting from all such reclassifications. 
  
 “Continuing Directors” means, as of any date of determination, any member of the Board of
Directors of Fisher who (i) was a member of the Board of Directors of Fisher on August 2, 2004 at any time after the Effective Time or (ii) was nominated for election or elected to the Board of Directors of Fisher with the approval of two-thirds of
the Continuing Directors who were members of the Board of Directors of Fisher at the time of a new director’s nomination or election. 
  

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 “Conversion Price” means the principal amount of CODES that can be
exchanged for one share of Common Stock ($59.09 immediately following the effective time of the merger of the Company and a Fisher Subsidiary on August 2, 2004, calculated as provided in Section 2.1 of the Supplemental Indenture), subject to
adjustments set forth herein. 
  
 “Conversion Rate” means the number of shares of Common Stock into which each $1,000 principal amount of CODES is convertible, (approximately 16.9233 immediately following the effective time of the merger of the Company and
a Fisher Subsidiary on August 2, 2004, calculated as provided in Section 2.1 of the Supplemental Indenture), subject to adjustments as set forth herein. 
  
 “Dividend Yield” on any security for any period means the dividends paid or proposed to be paid pursuant to an announced
dividend policy on such security for such period, divided by, if with respect to dividends paid on such security, the average Sale Price of such security during such period and, if with respect to dividends proposed to be paid on such security, the
Sale Price of such security on the effective date of the Reset Transaction. 
  
 “Obligations” means any principal, interest, including interest accruing on or after the filing of any petition of bankruptcy or for reorganization (whether or not a claim for post-filing interest is
allowed in such proceeding), redemption, repurchase, conversion amounts, penalties, fees, charges, expenses, indemnifications, reimbursement obligations, additional amounts, guarantees and other liabilities or amounts payable under the documentation
governing any indebtedness or in respect thereto. 
  
 “Transfer Agent” means Mellon Investor Services LLC (or any successor thereto). 
  
 SECTION 1.3. Addition of Certain Definitions to the Indenture. Section 1.1 of the Indenture is hereby amended to add the following defined terms:

  
 “Fisher” means Fisher
Scientific International Inc., a Delaware corporation, until a successor Person shall have become obligated under the Indenture pursuant to Section 12.4 of the Indenture as amended hereby. 
  
 “Fisher Subsidiary” means a corporation
more than 50% of the outstanding Voting Stock of which is owned, directly or indirectly, by Fisher or by one or more other such corporations, or by Fisher and one or more other such corporations. 
  
 “Supplemental Indenture” means the
supplemental indenture with respect to the CODES that is dated as of August 2, 2004 and is by and among Fisher, the Company and the Trustee. 
  

 5 

 SECTION 1.4. Modified Defined Terms. 
  
 (a) The references to the term “Company’s Common
Stock” in the definitions of “Reset Transaction” and “Trading Price” in Section 1.1 of the Indenture are hereby revised to refer to “Common Stock.” 
  
 (b) The references to the term “Officers’ Certificate” in Sections 5.1(j), 9.5 and 14.5 of
the Indenture are hereby revised to refer to an “Officers’ Certificate of the Company or Fisher, as applicable.” 
  
 (c) The references to the term “Officer” in Sections 9.5 and 14.5 of the Indenture are hereby revised to refer to an
“Officer of the Company or Fisher, as applicable.” 
  
 (d) The references to the term “Opinion of Counsel” in Section 14.5 of the Indenture are hereby revised to refer to an “Opinion of Counsel of the Company or Fisher, as applicable.” 
  
 ARTICLE II  
  
 Conversion Provisions 
  
 SECTION 2.1. Conversion into Common Stock of Fisher. 
  
 (a) Pursuant to the terms of Sections 12.1 and 12.4 of the Indenture, the
parties acknowledge that as a result of the Merger the Holder of each outstanding Securities on the date hereof became entitled to receive, upon conversion of such Securities, the same amount of Fisher Common Stock which such Holder would have been
entitled to receive upon the Merger had such Securities been converted into Apogent Common Stock immediately prior to the Merger. Accordingly, the parties acknowledge that as of the date of this Supplemental Indenture, and subject to future
adjustment as provided herein and in the Indenture, the Conversion Price immediately following the effective time of the Merger on August 2, 2004 is $59.09, which Conversion Price was calculated as follows: $33.09 per share of Apogent Common Stock
(the conversion price immediately before the Merger) divided by 0.56 (the exchange ratio in the Merger). Accordingly, the parties acknowledge that as of the date of this Supplemental Indenture, and subject to future adjustment as provided herein and
in the Indenture, the Conversion Rate is approximately 16.9233. 
  
 (b) The last sentence of the last paragraph of Section 12.1(a) is hereby revised to read as follows: 
  
 “At such time as a written request is made by a Holder, the Company shall instruct the Conversion Agent to determine the Trading Price of the CODES
beginning on the next Trading Day and on each successive Trading Day until the Trading Price of the CODES is greater than or equal to 98% 
 of the average Conversion Value for five consecutive Trading Days.” 
  

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 (c) Section 12.1(b) is hereby revised to read as follows: 
  
 “(b) In addition, in the event that: 
  
 (1) (A) Fisher distributes to all or substantially all holders of its
shares of Common Stock rights or warrants entitling them (for a period expiring within 60 days of the Record Date for such distribution) to subscribe for or purchase shares of Common Stock, at a price per share less than the Sale Price of the Common
Stock on the Business Day immediately preceding the announcement of such distribution, (B) Fisher distributes to all or substantially all holders of its shares of Common Stock, cash or other assets, debt securities or rights or warrants to purchase
its securities, where the Fair Market Value (as determined by the Board of Directors of Fisher) of such distribution per share of Common Stock exceeds 5% of the Sale Price of a share of Common Stock on the Business Day immediately preceding the date
of declaration of such distribution, or (C) a Change of Control occurs but Holders of CODES do not have the right to require the Company to purchase their CODES as a result of such Change of Control because either (i) the Sale Price of the Common
Stock for specified periods (as described in the definition of Change of Control) exceeds specified levels (as described in the definition of Change of Control) or (ii) the consideration received in such Change of Control consists of Capital Stock
that is freely tradable and the CODES become convertible into that Capital Stock as specified in the definition of Change of Control, then, in each case, the CODES may be surrendered for conversion at any time on and after the date that the Company
gives notice to the Holders of such right, which shall be not less than 20 days prior to the Ex-Dividend Time for such distribution, in the case of (A) or (B), or within 30 days after the occurrence of the Change of Control, in the case of (C),
until the earlier of the close of business on the Business Day immediately preceding the Ex-Dividend Time or the date the Company announces that such distribution will not take place, in the case of (A) or (B), or the earlier of 30 days after the
Company’s delivery of the Repurchase Notice for Change of Control Repurchase Rights or the date the Company announces that the Change of Control will not take place, in the case of (C), or 
  
 (2) Fisher consolidates with or merges into another corporation, or is a
party to a binding share exchange pursuant to which the shares of Common Stock would be converted into cash, securities or other property as set forth in Section 12.4 hereof, then the CODES may be surrendered for conversion at any time from and
after the date which is 15 days prior to the date announced by Fisher as the anticipated effective time of such transaction until 15 days after the actual date of such transaction. 
  
 The Conversion Rate, at any time, shall equal (A) $1,000 divided by the Conversion Price at such time,
rounded to three decimal places (rounded up if the fourth decimal place thereof is 5 or more and otherwise rounded down).” 
  

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 SECTION 2.2. Conversion Procedures Adjustments. 
  
 (a) The fourth sentence of Section 12.2(a) is hereby revised to read as
follows: “Fisher shall not issue any fraction of a share of Common Stock in connection with any conversion of CODES, but instead the Company shall, subject to Section 12.3(h) hereof, make a cash payment (calculated to the nearest cent) equal to
such fraction multiplied by the Sale Price of the Common Stock on the last Trading Day prior to the date of conversion.” 
  
 (b) The second and third sentences of the third paragraph of Section 12.2(b) are hereby revised to read as follows: 
  
 “Subject to the next succeeding sentence, Fisher will, as soon as
practicable thereafter, issue and the Company shall deliver at said office or place to such Holder of a Debenture, or to such Holder’s nominee or nominees, certificates for the number of full shares of Common Stock to which such Holder shall be
entitled as aforesaid, together, subject to the last sentence of Section 12.2(a) above, with cash in lieu of any fraction of a share to which such Holder would otherwise be entitled. Neither the Company nor Fisher shall be required to deliver
certificates for shares of Common Stock while the stock transfer books for such stock or the security register are duly closed for any purpose, but certificates for shares of Common Stock shall be issued and delivered as soon as practicable after
the opening of such books or security register.” 
  
 SECTION
2.3. Conversion Price Adjustment. 
  
 (a)
All provisions in Section 12.3 of the Indenture regarding adjustments to the Conversion Price shall remain in full force and effect, except that: 
  
 (i) all references to the Company contained in paragraphs (a), (b), (c), (d), (e), (f), (j) and (l) of Section 12.3 of the Indenture
(other than the first two references to the Company in the seventh paragraph of Section 12.3(d)) are hereby revised to refer to Fisher; and 
  
 (ii) all references to the Board of Directors in Section 12.3 of the Indenture shall refer to the Board of Directors of Fisher; and

  
 (iii) The reference to “the
Company’s Subsidiaries” in the first sentence of the third paragraph of Section 12.3(d) of the Indenture is hereby revised to refer to “Fisher Subsidiaries”; and 
  
 (b) The last paragraph of Section 12.3(f) of the Indenture is hereby deleted in its entirety. 
  
 SECTION 2.4 Consolidation or Merger. 
  
 (a) The references to the Company in (i) the heading of Section 12.4, (ii)
the first paragraph of Section 12.4 of the Indenture (including in subparagraphs (2) and (3) thereof and in the first line of the continuation following those subparagraphs), and (iii) the last sentence of Section 12.4, are each hereby revised to
refer to Fisher. 
  

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 (b) The reference to Article 12 in the last sentence of the first paragraph of Section 12.4 is hereby
revised to refer to Article 11. 
  
 SECTION 2.5 Notices of
Certain Events. All references to the Company in Section 12.6 are hereby revised to refer to Fisher. 
  
 SECTION 2.6 Reservation of Common Stock; Registration; Listing and Taxes on Conversion. All references to the Company in Sections 12.7 and 12.8 are
hereby revised to refer to Fisher. The reference in the first sentence of Section 12.7(a) to the laws of the State of Wisconsin is hereby revised to refer to the laws of the State of Delaware. 
  
 SECTION 2.7 Determinations Final; Responsibility of Trustee. All
references to “the Company” in Sections 12.10 and 12.11, including the heading of Section 12.10, are hereby revised to refer to “the Company or Fisher”. All references to the “Board of Directors” or “Board
Resolution” in Section 12.10 are hereby deemed to refer to the Board of Directors of a Board Resolution of the Company or Fisher. 
  
 ARTICLE III 
  
 Additional Amendments to Protect Interests of the Holders 
  
 SECTION 3.1 Notice of Defaults. The second sentence of Section 5.6 of the Indenture is hereby revised to read as follows: 
  
 “The proviso in the first sentence of this Section 5.6 shall be in lieu
of the proviso to Section 315(b) of the TIA and such proviso is hereby expressly excluded from this Indenture, as permitted by the TIA.” 
  
 SECTION 3.2 Reports by Trustee to Holders. The second paragraph of Section 5.7 of the Indenture is hereby revised to read as follows: 

 
 “A copy of each report at the time of its mailing to Holders shall
be filed with the Commission, if required, and each stock exchange, if any, on which the Securities or the Common Stock are listed. The Company or Fisher, as applicable, shall promptly notify the Trustee when the Securities or the Common Stock
become listed on any stock exchange and of any delisting thereof.” 
  
 SECTION 3.3 Successor Corporation Substituted. The second sentence of Section 6.2 of the Indenture is hereby amended to delete the following phrase: “the predecessor corporation.” 
  
 SECTION 3.4 Amendments, Supplements and Waivers Without Consent of Holders
of CODES. Section 7.1(c) of the Indenture is hereby amended and restated to read as follows: 
  
 “(c) provide for conversion rights of Holders of CODES if any reclassification or change of the Common Stock or any consolidation, merger or sale of
all or substantially all of Fisher’s assets occurs;” 
  

 9 

 SECTION 3.5 Corporate Existence. Section 9.3 of the Indenture is hereby amended and restated as
follows: 
  
 “Each of Fisher and, subject to Article 6
hereof, the Company will do or cause to be done all things necessary to preserve and keep in full force and effect its corporate existence, rights (charter and statutory) and franchises (and in the case of the Company, franchises of each Subsidiary;
provided, however, that each of Fisher and the Company shall not be required to preserve any such right or franchise if its Board of Directors shall determine in good faith that the preservation thereof is no longer desirable in the conduct
of the business of it and its Subsidiaries as a whole and that the loss thereof is not disadvantageous in any material respect to the Holders.” 
  
 SECTION 3.6 Tax Treatment of CODES. Section 9.7 of the Indenture is hereby amended and restated to read as follows: 
  
 The Company agrees, and by acceptance of beneficial ownership interest in
the CODES each beneficial holder of CODES will be deemed to have agreed, unless otherwise required by the Internal Revenue Service, for United States federal income tax purposes (1) to treat the CODES as indebtedness that is subject to Treas. Reg.
Sec. 1.1275-4 (the “Contingent Payment Regulations”) and, for purposes of the Contingent Payment Regulations, to treat the fair market value of any stock beneficially received by a beneficial holder upon any conversion of the CODES
as a contingent payment and (2) to be bound by the Company’s determination of the “comparable yield” and “projected payment schedule,” within the meaning of the Contingent Payment Regulations, with respect to the CODES. A
Holder of CODES may obtain the amount of original issue discount, issue date, yield to maturity, comparable yield and projected payment schedule by submitting a written request for it to the Company at the address specified in accordance with
Section 14.2. 
  
 SECTION 3.7 Repurchase Rights. Section 11.1(b)
of the Indenture is hereby amended and restated as follows: 
  
 (b) Change of Control Put. 
  
 In the
event that a Change of Control shall occur, each Holder shall have the right (each, a “Change of Control Repurchase Right” and, together with the Optional Repurchase Right, each a “Repurchase Right”), at the
Holder’s option, but subject to the provisions of Section 11.2 hereof, to require the Company to repurchase, and upon the exercise of such right the Company shall repurchase, all of such Holder’s CODES not theretofore called for
redemption, or any portion of the principal amount thereof that is equal to $1,000 or an integral multiple thereof as directed by such Holder pursuant to Section 11.3 (provided that no single CODES may be repurchased in part unless the portion of
the principal amount of such CODES to be Outstanding after such repurchase is equal to $1,000 or an integral multiple thereof), on the date (the “Change of Control Repurchase Date” and, together with the Optional Repurchase Date,
each a “Repurchase Date”) that is a Business Day no earlier than 30 days nor later than 60 days after the date of the Company Notice at a purchase price in cash equal to 100% of the 
  

 10 

 principal amount of the CODES to be repurchased (the “Change of Control Repurchase
Price” and, together with the Optional Repurchase Price, each a “Repurchase Price”), plus accrued and unpaid Interest (including Contingent Interest) to, but excluding, the Change of Control Repurchase Date; provided,
however, that installments of Interest (including Contingent Interest) on CODES whose Stated Maturity is prior to or on the Change of Control Repurchase Date shall be payable to the Holders of such CODES, or one or more Predecessor Securities,
registered as such on the relevant Regular Record Date according to the terms and provisions of Section 2.1 hereof.  
  
 ARTICLE IV 
  
 Miscellaneous 
  
 SECTION 4.1 Notices. All notices and other communications to Fisher, the Company or any Guarantor shall be given as provided in the Indenture (or any supplemental indenture thereto). For purposes of Section
14.2, the addresses of Fisher and the Company are as follows: 
  
 Fisher Scientific International Inc. 
 One Liberty Lane 
 Hampton, New Hampshire 03842 
 Fax: (603)
929-2379 
 Attention: General Counsel 
  
 With a copy to: 
  
 Skadden, Arps, Slate, Meagher & Flom LLP 
 Four Times Square 
 New York, New York 10036-6522 
 Fax: (212) 735-2000 
 Attention: Richard Aftanas, Esq. 
  
 Apogent Technologies Inc. 
 c/o Fisher Scientific International Inc. 
 One
Liberty Lane 
 Hampton, New Hampshire 03842 
 Attn: General Counsel 
 Fax: (603) 929-2379 
  
 SECTION 4.2 Parties. Nothing expressed or mentioned herein is intended or shall be construed to give any Person, firm
or corporation, other than the Holders and the Trustee, any legal or equitable right, remedy or claim under or in respect of this Supplemental Indenture or the Indenture or any provision herein or therein contained. 
  
 SECTION 4.3. Governing Law. This Supplemental Indenture shall be
governed by the laws of the State of New York. 
  

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 SECTION 4.4. Severability Clause. In case any provision in this Supplemental Indenture shall be
invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby and such provision shall be ineffective only to the extent of such invalidity, illegality
or unenforceability. 
  
 SECTION 4.5 Ratification of Indenture;
Supplemental Indentures Part of Indenture; Trustee’s Disclaimer. Except as expressly amended hereby, the Indenture is in all respects ratified and confirmed and all the terms, conditions and provisions thereof shall remain in full force and
effect. This Supplemental Indenture shall form a part of the Indenture for all purposes, and every Holder of Securities heretofore or hereafter authenticated and delivered shall be bound hereby. The Trustee makes no representation or warranty as to
the validity or sufficiency of this Supplemental Indenture. 
  
 SECTION 4.6. Counterparts. The parties hereto may sign one or more copies of this Supplemental Indenture in counterparts, all of which together shall constitute one and the same agreement. 
  
 SECTION 4.7. Headings. The headings of the Articles and the sections
in this Supplemental Indenture are for convenience of reference only and shall not be deemed to alter or affect the meaning or interpretation of any provisions hereof. 
  

 12 

 Exhibit 4.4 
  
 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly executed as of the date first
above written. 
  

			
	 FISHER SCIENTIFIC INTERNATIONAL INC.

		
	 By:
	 	 /s/ Kevin P. Clark

	 Name:
	 	Kevin P. Clark
	 Title:
	 	Vice President and Chief Financial Officer
	
	 APOGENT TECHNOLOGIES INC.

		
	 By:
	 	 /s/ Michael K. Bresson

	 Name:
	 	Michael K. Bresson
	 Title:
	 	Executive Vice President – Administration, General Counsel and Secretary
	
	 THE BANK OF NEW YORK, as Trustee

		
	 By:
	 	 /s/ Van Brown

	 Name:
	 	Van Brown
	 Title:
	 	Vice PresidentSUPPLEMENTAL INDENTURE, DATED AS OF JULY 27, 2004

 Exhibit 4.5 
  

SUPPLEMENTAL INDENTURE 
  
 SUPPLEMENTAL INDENTURE, dated as of July 27, 2004 (this “Third Supplemental Indenture”), by and between Apogent Technologies Inc., a
Wisconsin corporation (the “Company”), having its principal office at 30 Penhallow Street, Portsmouth, New Hampshire 03801 and The Bank of New York, a New York banking corporation, as Trustee (the “Trustee”) to the
Indenture (as defined below), having its principal corporate trust office at 101 Barclay Street, Floor 8 West, New York, New York 10286. 
  
 W I T N E S S E T H: 
  
 WHEREAS, the Company, the guarantors identified on the signature pages thereto (collectively, the “Initial Guarantors”) and the Trustee
have heretofore executed and delivered an Indenture, dated as of June 2, 2003, (the “Original Indenture”) pursuant to which the Company issued $250 million aggregate principal amount of 61⁄2% Senior Subordinated Notes due
2013 (the “Notes”); 
  
 WHEREAS, the Company, the
guarantors identified on the signature pages to the Original Indenture, Quality Scientific Plastics, Inc. (the “First Supplemental Guarantor”) and the Trustee have heretofore executed and delivered a Supplemental
Indenture, dated as of September 2, 2003 (the “First Supplemental Indenture”); 
  
 WHEREAS, the Company, the guarantors identified on the signature pages to the Original Indenture, the Trustee and ARG Services LLC, EP Scientific Products
LLC and PACTECH, LLC (collectively, the “Second Supplemental Guarantors” and together with the Initial Guarantors and the First Supplemental Guarantor, the “Guarantors”) have heretofore executed and
delivered a Supplemental Indenture, dated as of April 12, 2004 (the “Second Supplemental Indenture and, together with the Original Indenture and the First Supplemental Indenture, the “Indenture”);

  
 WHEREAS, Section 9.02 of the Original Indenture provides that
the Company and the Trustee may, with certain exceptions, amend the Indenture, the Notes and the Subsidiary Guarantees (as defined in the Indenture) with the consent of the Holders (as defined in the Original Indenture) of at least a majority in
principal amount of the Notes; 
  
 WHEREAS, the Company has
distributed an Offer to Purchase and Consent Solicitation Statement, dated as of May 28, 2004, as amended by the Amended Offer to Purchase and Consent Solicitation Statement, dated as of July 13, 2004 (as amended, the “Solicitation
Statement”), and accompanying Letter of Transmittal and Consent, dated as of May 28, 2004, as amended by the Amended Letters of Transmittal and Consent, dated as of July 13, 2004, to the Holders of the Notes in connection with certain proposed
amendments to the Indenture as described in the Solicitation Statement (the “Proposed Amendments”); 
  
 WHEREAS, the Holders of at least a majority of the outstanding principal amount of the Notes have duly consented to the Proposed Amendments; and

 WHEREAS, the execution and delivery of this Third Supplemental Indenture have been duly authorized by all
necessary corporate action on the part of the Company and all conditions and requirements necessary to make this instrument a valid and binding agreement have been duly performed and complied with. 
  
 NOW THEREFORE, in consideration of the foregoing and for other good and
valuable consideration, the receipt and sufficiency of which is hereby acknowledged, the Company and the Trustee mutually covenant and agree, for the equal and ratable benefit of the Holders of the Notes, as follows: 
 ARTICLE I- AMENDMENTS 
  
 Section 1.1. Amendments to the Indenture and Notes. 
  
 (a) The following Sections and Articles of the Original Indenture, and any corresponding provisions in the Notes, are hereby deleted in their entirety
and replaced with “Intentionally Omitted.”: 
  

			
	Existing Section/Article Number

	  	 Caption

	Section 3.09	  	Offer to Purchase by Application of Excess Proceeds
		
	Section 4.03	  	Reports
		
	Section 4.07	  	Restricted Payments
		
	Section 4.08	  	Dividend and Other Payment Restrictions Affecting Subsidiaries
		
	Section 4.09	  	Incurrence of Indebtedness and Issuance of Preferred Stock
		
	Section 4.10	  	Asset Sales
		
	Section 4.11	  	Transactions with Affiliates
		
	Section 4.12	  	Liens
		
	Section 4.13	  	Business Activities
		
	Section 4.15	  	Offer to Repurchase Upon a Change of Control
		
	Section 4.19	  	Termination of Covenants when Notes Rated Investment Grade

  
 (b) The following
definitions listed in Section 1.01 of the Original Indenture are hereby deleted and replaced with “Intentionally Omitted.”: 
  
 “Acquired Debt” 
 “Beneficial Owner” 
 “Change of Control” 
 “Common Stock Tender Offer” 
 “Consolidated Assets” 
 “Consolidated Cash Flow” 
 “Consolidated Net Income” 
 “Consolidated Net Worth” 
  

 2 

 “Existing Indebtedness” 
 “Fixed Charges” 
 “Fixed Charge Coverage Ratio” 
 “Foreign Restricted Subsidiary”

 “Investment Grade” 
 “Investments” 
 “Net Income” 
 “Permitted Investments” 
 “Permitted Refinancing Indebtedness” 
 “Rating Agency” 
 “Restricted Investment” 
 “Voting Stock” 
  
 (c)
The definition of “Additional Notes” in Section 1.01 of the Original Indenture is hereby amended by deleting the reference to Section 4.09. 
  
 (d) Clause (1) of the definition of “Asset Sale” in Section 1.01 of the Indenture is hereby deleted and replaced with the following:

  
 “the sale, lease, conveyance or other disposition of
any assets or rights, other than sales of inventory in the ordinary course of business consistent with past practices; provided that the sale, conveyance or other disposition of all or substantially all of the assets of the Company and its
Restricted Subsidiaries taken as a whole shall be governed by Section 5.01 hereof; and” 
  
 (e) Clause (6) of the definition of “Asset Sale” in Section 1.01 of the Original Indenture is hereby deleted and replaced with “Intentionally Omitted.” 
  
 (f) The definition of “Credit Facilities” in Section 1.01 of the
Original Indenture is hereby amended by deleting the following: “, provided that such increase is permitted by Section 4.09.” 
  
 (g) The definition of “Disqualified Stock” in Section 1.01 of the Original Indenture is hereby amended by deleting the last sentence of the
definition. 
  
 (h) The last paragraph of the definition of
“Unrestricted Subsidiary” in Section 1.01 of the Original Indenture is deleted and replaced with the following: 
  
 “Any designation of a Subsidiary of the Company as an Unrestricted Subsidiary shall be evidenced to the Trustee by filing with the Trustee a certified copy of the
Board Resolution giving effect to such designation and an Officers’ Certificate certifying that such designation complied with the preceding conditions. If, at any time, any Unrestricted Subsidiary would fail to meet the preceding requirements
as an Unrestricted Subsidiary, it shall thereafter cease to be an Unrestricted Subsidiary for purposes of this Indenture and any Indebtedness of such Subsidiary shall be deemed to be incurred by a Restricted Subsidiary of the Company as of such
date. The Board of Directors of the 
  

 3 

 Company may at any time designate any Unrestricted Subsidiary to be a Restricted Subsidiary; provided that such
designation shall be deemed to be an incurrence of Indebtedness by a Restricted Subsidiary of the Company of any outstanding Indebtedness of such Unrestricted Subsidiary and such designation shall only be permitted if no Default or Event of Default
would be in existence following such designation.” 
  
 (i)
The following definitions listed in Section 1.02 of the Original Indenture are hereby deleted and replaced with “Intentionally Omitted”: 
  
 “Affiliate Transaction” 
 “Asset Sale Offer” 
 “Change of Control Offer” 
 “Change of Control Payment” 
 “Change of Control Payment Date” 
 “Excess Proceeds” 
 “incur” 
 “Offer Amount” 
 “Offer Period” 
 “Permitted Debt” 
 “Purchase Date” 
 “Restricted Payments” 
  
 (j) The references in paragraph (i) of Section 2.06 of the Original
Indenture to Sections 3.09, 4.10 and 4.15 of the Indenture are hereby deleted. 
  
 (k) The first sentence of Section 3.03 of the Original Indenture is hereby amended by deleting the following: “Subject to the provisions of Section 3.09 hereof.” 
  
 (l) The first sentence of the second paragraph of Section 4.17 of the
Original Indenture is hereby deleted and replaced with the following: “Notwithstanding the foregoing, no existing or newly acquired or created Subsidiary that is not already a Guarantor shall be required to execute a supplemental indenture
unless such Subsidiary Guarantees Indebtedness of the Company under the Credit Facility.” 
  
 (m) The second and third sentences of Section 4.18 of the Original Indenture are hereby deleted. 
  
 (n) Clause (4) of Section 5.01 of the Original Indenture is hereby deleted
and replaced with “Intentionally Omitted.” 
  
 (o) The
first sentence of the paragraph immediately following paragraph (4) of Section 5.01 of the Original Indenture is hereby deleted. 
  
 (p) The references in clause (3) of Section 6.01 of the Original Indenture to Sections 4.10 and 4.15 of the Indenture are hereby deleted. 
  

 4 

 (q) Clauses (4), (6), (7), (9) and (10) of Section 6.01 of the Original Indenture are hereby deleted and
replaced with “Intentionally Omitted.” 
  
 (r) The
first sentence of the first paragraph and the second sentence of the second paragraph of Section 6.02 of the Original Indenture are hereby deleted. 
  
 (s) The second sentence of the first paragraph of Section 6.02 of the Original Indenture is hereby amended to delete the following: “other.”

  
 (t) Paragraph (e) of Section 7.07 of the Original Indenture
is hereby deleted and replaced with the following: 
  
 “When
the Trustee incurs expenses or renders services after: 
  
 (1)
the Company or any of its Restricted Subsidiaries that is a Significant Subsidiary or any group of Restricted Subsidiaries that, taken as a whole, would constitute a Significant Subsidiary pursuant to or within the meaning of any Bankruptcy Law:

  
 (A) commences a voluntary case, 
  
 (B) consents to the entry of an order for relief against it in an
involuntary case, 
  
 (C) consents to the appointment of a
custodian of it or for all or substantially all of its property, 
  
 (D) makes a general assignment for the benefit of its creditors, or 
  
 (E) generally is not paying its debts as they be-come due; or 
  
 (2) a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that: 
  
 (A) is for relief against the Company or any of its Restricted Subsidiaries that is a Significant Subsidiary or any group of Restricted Subsidiaries that,
taken as a whole, would constitute a Significant Subsidiary in an involuntary case; 
  
 (B) appoints a custodian of the Company or any of its Restricted Subsidiaries that is a Significant Subsidiary or any group of Restricted Subsidiaries that, taken as a whole, would constitute a Significant Subsidiary
or for all or substantially all of the property of the Company or any of its Restricted Subsidiaries that is a Significant Subsidiary or any group of Restricted Subsidiaries that, taken as a whole, would constitute a Significant Subsidiary; or

  

 5 

 (C) orders the liquidation of the Company or any of its Restricted Subsidiaries that is a Significant
Subsidiary or any group of Restricted Subsidiaries that, taken as a whole, would constitute a Significant Subsidiary; 
  
 and the order or decree remains unstayed and in effect for 60 consecutive days, the expenses and the compensation for the services (including the fees and
expenses of its agents and counsel) are intended to constitute expenses of administration under any Bankruptcy Law.” 
  
 (u) The references in Section 8.03 of the Original Indenture to Sections 4.07, 4.08, 4.09, 4.10, 4.11, 4.12, 4.13, 4.15, 4.19 and clause (4) of Section
5.01 of the Original Indenture are hereby deleted. 
  
 (v) The
last sentence in Section 8.03 of the Original Indenture is hereby deleted and replaced with the following: “In addition, upon the Company’s exercise under Section 8.01 hereof of the option applicable to this Section 8.03 hereof, subject to
the satisfaction of the conditions set forth in Section 8.04 hereof, Section 6.01(3) and 6.01(5) hereof will not constitute Events of Default.” 
  
 (w) The first paragraph of Section 9.02 of the Original Indenture is hereby amended by deleting the following: “(including, without limitation,
Sections 3.09, 4.10 and 4.15 hereof).” 
  
 (x) Clause (2) of
the fourth paragraph of Section 9.02 of the Original Indenture is hereby amended by deleting the following: “except as provided above with respect to Sections 3.09, 4.10 and 4.15 hereof.” 
  
 (y) Clause (7) of the fourth paragraph of Section 9.02 of the Original
Indenture is hereby amended by deleting “(including a payment required by Sections 3.09, 4.10 and 4.15 hereof).” 
  
 (z) Clause (2)(b) of Section 10.04 of the Original Indenture is hereby amended by deleting “, including without limitation, Section 4.10
hereof.” 
  
 (aa) Paragraph (a) of Section 10.05 of the
Original Indenture is hereby amended by deleting the two instances of “, including without limitation, Section 4.10 hereof.” 
  
 (bb) Paragraph (c) of Section 10.05 of the Original Indenture is hereby amended by deleting the following: “and at any time after the termination of
certain covenants as provided in Section 4.19 of this Indenture.” 
  
 (cc) Pursuant to Section 4 of the Notes, any definitions used exclusively in the provisions of the Notes that are deleted pursuant to this Section 1.1, and any definitions used exclusively within such definitions, are hereby deleted in
their entirety from the Notes, and all references in the Notes to paragraphs, Sections, Articles or other terms or provisions of the Original Indenture referred to in this Section 1.1 or that have been otherwise deleted pursuant to this Third
Supplemental Indenture are hereby deleted in their entirety or revised to conform herewith. 
  

 6 

 ARTICLE II- MISCELLANEOUS 
  
 Section 2.1. Effect of Supplemental Indenture. From and after the Amendment Operative Date (as defined in Section
2.14 hereof), the Indenture and the Notes shall be supplemented in accordance herewith, and this Third Supplemental Indenture shall form a part of the Indenture and the Notes for all purposes, and every Holder of Notes heretofore or hereafter
authenticated and delivered under the Indenture shall be bound thereby. 
  
 Section 2.2. Indenture Remains in Full Force and Effect. Except as supplemented by this Third Supplemental Indenture, all provisions in the Indenture and the Notes shall remain in full force and effect. 
  
 Section 2.3. References to Supplemental Indenture. Any and all
notices, requests, certificates and other instruments executed and delivered after the execution and delivery of this Third Supplemental Indenture may refer to the Indenture without making specific reference to this Third Supplemental Indenture, but
nevertheless all such references shall include this Third Supplemental Indenture unless the context requires otherwise. 
  
 Section 2.4. Conflict with Trust Indenture Act. If any provision of this Third Supplemental Indenture limits, qualifies or conflicts with any
provision of the TIA that is required under the TIA to be part of and govern any provision of this Third Supplemental Indenture, the provision of the TIA shall control. If any provision of this Third Supplemental Indenture modifies or excludes any
provision of the TIA that may be so modified or excluded, the provision of the TIA shall be deemed to apply to the Indenture as so modified or to be excluded by this Third Supplemental Indenture, as the case may be. 
  
 Section 2.5. Severability. If any court of competent jurisdiction
shall determine that any provision in this Third Supplemental Indenture shall be invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby.

  
 Section 2.6. Terms Defined in the Indenture. All
capitalized terms not otherwise defined herein shall have the meanings ascribed to them in the Indenture. 
  
 Section 2.7. Headings. The Article and Section headings of this Third Supplemental Indenture have been inserted for convenience of reference only,
are not to be considered a part of this Third Supplemental Indenture and shall in no way modify or restrict any of the terms or provisions hereof. 
  

 7 

 Section 2.8. Benefits of Third Supplemental Indenture. Nothing in this Third Supplemental
Indenture or the Notes, express or implied, shall give to any Person, other than the parties hereto and thereto and their successors hereunder and thereunder and the Holders of the Notes any benefit of any legal or equitable right, remedy or claim
under the Indenture, this Third Supplemental Indenture or the Notes. 
  
 Section 2.9. Successors. All agreements of the Company in this Third Supplemental Indenture shall bind their respective successors. All agreements of the Trustee in this Third Supplemental Indenture shall bind its successors.

  
 Section 2.10. Trustee Not Responsible for Recitals. The
recitals contained herein shall be taken as the statements of the Company and the Guarantors and the Trustee assumes no responsibility for their correctness. 
  
 Section 2.11. Certain Duties and Responsibilities of the Trustee. In entering into this Third Supplemental Indenture, the Trustee shall be entitled
to the benefit of every provision of the Indenture and the Notes relating to the conduct or affecting the liability or affording protection to the Trustee, whether or not elsewhere herein so provided. 
  
 Section 2.12. Governing Law. This Third Supplemental Indenture shall
be governed by, and construed in accordance with, the laws of the State of New York but without giving effect to applicable principles of conflicts of law to the extent that the application of the laws of another jurisdiction would be required
thereby. 
  
 Section 2.13. Counterpart Originals. The
parties may sign any number of copies of this Third Supplemental Indenture. Each signed copy shall be an original, but all of them together represent the same agreement. 
  
 Section 2.14. Effectiveness. This Third Supplemental Indenture shall become effective upon execution by the Company
and the Trustee. As used herein, the “Amendment Operative Date”, which is the date that the Proposed Amendments shall be operative, shall mean the date that the Company delivers written notice to the Trustee that that the Notes tendered
and not validly withdrawn pursuant to the Solicitation Statement are accepted and purchased by the Company. 
  

 8 

 IN WITNESS WHEREOF, the parties hereto have caused this Third Supplemental Indenture to be duly executed as of the date
first above written. 
  

			
	 APOGENT TECHNOLOGIES INC.

		
	 By:
	 	 /s/ Michael K. Bresson

	 Name:
	 	 Michael K. Bresson

	 Title:
	 	 Executive Vice President – Administration, General Counsel and Secretary

  

			
	 The Bank of New York,

	 as Trustee and not in

	 its individual capacity

		
	 By:
	 	 /s/ Robert A. Massimillo

	 Name:
	 	 Robert A. Massimillo

	 Title:
	 	 Vice President

  

 9

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