Document:

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                                                                   EXHIBIT 10.25

                              TERMINATION AGREEMENT

         THIS TERMINATION AGREEMENT, dated as of __________, ______ is made and
entered into by and between Texas Biotechnology Corporation, a Delaware
corporation with its principal office at 7000 Fannin, Houston, Texas 77030 (the
"Company"), and __________________ ("Executive").

                                    RECITALS

         A. The Company and the Executive have entered into an Employment
Agreement dated ___________ concerning the employment of the Executive as the
___________ and _______________________ of the Company.

         B. Company desires to enter into an agreement with Executive whereby
severance benefits will be paid to Executive on a change in control of the
Company and consequent actual or constructive termination of Executive's
employment.

         C. This Agreement sets forth the severance benefits which the Company
agrees that it will pay to the Executive if Executive's employment with the
Company terminates under one of the circumstances described herein following a
Change in Control of the Company.

         NOW, THEREFORE, in consideration of the foregoing premises and the
mutual covenants contained herein, the parties hereto agree as follows:

         1. Term of Agreement. This Agreement shall be effective immediately on
the date hereof and shall continue in effect through December 31, _____;
provided, however, that commencing on January 1, _____ and each January 1
thereafter, the term of this Agreement shall automatically be extended for one
additional year unless not later than September 30 of the preceding year, the
Company shall have given notice that it does not wish to extend this Agreement;
provided, further, that notwithstanding any such notice by the Company not to
extend this Agreement shall automatically be extended for 24 months beyond the
term provided herein if a Change in Control, as defined in Section 3 of this
Agreement has occurred during the term of this Agreement.

         2. Effect on Employment Rights. This Agreement is not part of the
Employment Agreement or any other employment agreement that the Company and
Executive may have entered. Nothing in this Agreement shall confer upon
Executive any right to continue in the employ of the Company or interfere with
or restrict in any way the rights of the Company, which are hereby expressly
reserved, to terminate for any reason, with or without cause.

         Executive agrees that, subject to the terms and conditions of this
Agreement, in the event of a potential change in control of the Company (as
defined below), Executive will remain in the employ of the Company during the
pendency of any such potential change in control and for a period of one year
after the occurrence of an actual Change in Control. For this purpose, a
"potential change in control of the Company" shall be deemed to have occurred if
(a) the Company enters into an agreement the consummation of which would result
in the occurrence of a Change in Control, (b) any person (including the Company)
publicly announces an intention to take or consider taking action which if
consummated would constitute a Change in Control or (c) the Board of Directors
of the Company (the "Board") adopts a resolution to the effect that a potential
change in control of the Company has occurred.

         3. Change in Control. For purposes of this Agreement, a "Change in
Control" of the Company shall be deemed to have occurred if any of the events
set forth in any one of the following paragraphs shall occur:

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                  (a) any "person" (as defined in section 3(a)(9) of the
         Securities Exchange Act of 1934, as amended (the "Exchange Act") and as
         such term is modified in sections 13(d) and 14(d) of the Exchange Act),
         excluding the Company or any of its subsidiaries, a trustee or any
         fiduciary holding securities under an employee benefit plan of the
         Company of any of its subsidiaries, an underwriter temporarily holding
         securities pursuant to an offering of such securities or a corporation
         owned, directly or indirectly, by stockholders of the Company in
         substantially the same proportions as their ownership of the Company,
         is or becomes the "beneficial owner" (as defined in Rule 13d-3 under
         the Exchange Act), directly or indirectly, of securities of the Company
         representing 30% or more of the combined voting power of the Company's
         then outstanding securities; or

                  (b) during any period of not more than two consecutive years,
         individuals who at the beginning of much period constitute the Board
         and any new director (other than a director designated by a Person who
         has entered into an agreement with the Company to effect a transaction
         described in clause (a), (c) or (d) of this paragraph) whose election
         by the Board or nomination for election by the Company's stockholders
         was approved by a vote of at least two-thirds (2/3) of the directors
         then still in office who either were directors at the beginning of the
         period or whose election or nomination for election was previously so
         approved, cease for any reason to constitute a majority thereof; or

                  (c) the shareholders of the Company approve a merger or
         consolidation of the Company with any other corporation, other than (i)
         a merger or consolidation which would result in the voting securities
         of the Company outstanding immediately prior thereto continuing to
         represent (either by remaining outstanding or by being converted into
         voting securities of the surviving entity), in combination with the
         ownership of any trustee or other fiduciary holder of securities under
         an employee benefit plan of the Company, at least 50% of the combined
         voting power of the voting securities of the Company or such surviving
         entity outstanding immediately after such merger or consolidation, or
         (ii) a merger or consolidation effected to implement a recapitalization
         of the Company (or similar transaction) in which no person acquires
         more than 50% of the combined voting power of the Company's then
         outstanding securities; or

                  (d) the shareholders of the Company approve a plan of complete
         liquidation of the Company or an agreement for the sale or disposition
         by the Company of all or substantially all of the Company's assets.

         Notwithstanding the foregoing, no Change in Control shall be deemed to
         have occurred if there is consummated any transaction or series of
         integrated transactions immediately following which, in the judgment of
         the Compensation Committee of the Board, the holders of the Company's
         Common Stock immediately prior to such transaction or series of
         transactions continue to have the same proportionate ownership in an
         entity which owns all or substantially all of the assets of the Company
         immediately prior to such transaction or series of transactions. Except
         during a potential change of control of the Company (as defined in
         Section 2 above), the Board may (i) deem any other corporate event
         affecting the Company (other than those described in paragraph 3(a)-(d)
         above) to be a "Change of Control", and (ii) may amend this provision
         and the definition of "Change of Control" in connection with an
         identical amendment being made to the Termination Agreements entered
         into by the Company and all of its executives.

         4. Termination of Employment Following a Change in Control. Executive
shall be entitled to the benefits provided in Section 5 hereof upon the
subsequent termination of Executive's employment by the Company within two years
after a Change in Control which occurs during the term of this Agreement,
provided such termination is (a) by the Company other than for cause, as defined
below, or (b) by Executive for Good Reason, as defined below. Executive shall
not be entitled to the benefits of Section 5, any other provision hereof to the
contrary notwithstanding, if Executive's employment terminates: (i) pursuant to
Executive retiring at age 65, (ii) by reason of Executive's total and permanent
disability, or (iii) by reason or Executive's death. As used herein, "total and
permanent disability" means an illness or other disability which prevents the
Executive from discharging his responsibilities under the Employment Agreement

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for a period of 180 consecutive calendar days, or an aggregate of 180 calendar
days in any calendar year, all as determined in good faith by the Board (or a
committee thereof).

                  (a)      Cause.

                           (i) Definition. Termination by the Company of
                  Executive's employment for Cause shall mean termination upon
                  (i) the conviction (or plea of nolo contendere or equivalent
                  plea) of the Executive of a felony (which, through lapse of
                  time or otherwise, is not subject to appeal), (ii) the
                  Executive having engaged in intentional misconduct causing a
                  material violation by the Company of any state or federal
                  laws, (iii) the Executive having engaged in a theft of
                  corporate funds or corporate assets or in an act of fraud upon
                  the Company, (iv) an act of personal dishonesty taken by the
                  Executive that was intended to result in personal enrichment
                  of the Executive at the expense of the Company, (v) the
                  Executive's refusal, without proper legal cause, to perform
                  his duties and responsibilities as President and Chief
                  Executive Officer or (vi) the Executive's engaging in
                  activities which would (A) constitute a breach of any term of
                  the Employment Agreement, the Company's Code of Ethics, the
                  Company's policies regarding trading in the Common Stock or
                  any other applicable policies, rules or regulations of the
                  Company, or (B) result in a material injury to the business,
                  condition (financial or otherwise), results of operations or
                  prospects of the Company (as determined in good faith by the
                  Board or a committee thereof). For purposes of this definition
                  of "Cause", the term "Company" shall mean the Company and/or
                  its subsidiaries and affiliates. No act, or failure to act, on
                  Executive's part shall be considered "intentional" unless
                  done, or omitted to be done, by Executive not in good faith
                  and without reasonable belief that Executive's action or
                  omission was in the best interest of the Company or its
                  subsidiaries. Notwithstanding the foregoing, Executive shall
                  not be deemed to have been terminated for Cause unless and
                  until there shall have been delivered to Executive a copy of a
                  resolution duly adopted by the affirmative vote of not less
                  than three quarters of the entire membership of the Board at a
                  meeting of the Board called and held for the purpose of making
                  a determination of whether Cause for termination exists (after
                  reasonable notice to Executive and an opportunity for
                  Executive to be heard before the Board), finding that in the
                  good faith opinion of the Board Executive was guilty of
                  misconduct as set forth above in this subsection 4(a)(i) and
                  specifying the particulars thereof in detail.

                           (ii) Remedy by Executive. If the Company gives
                  Executive a Notice of Termination which states that the basis
                  for terminating Executive's employment is Cause, Executive
                  shall have ten days after receipt of such Notice to remedy the
                  facts and circumstances which provided Cause. The Board (or
                  any duly authorized Committee thereof) shall make a good faith
                  reasonable determination immediately after such ten-day period
                  whether such facts and circumstances have been remedied and
                  shall communicate such determination in writing to Executive.
                  If the Board determines that an adequate remedy has not
                  occurred, then the initial Notice of Termination shall remain
                  in effect.

                  (b) Good Reason. After a Change in Control, Executive may
         terminate employment with the Company at any time during the term of
         this Agreement if Executive has made a good faith reasonable
         determination that Good Reason exists for this termination.

                           (i) Definition. For purposes of this Agreement, "Good
                  Reason" shall mean any of the following actions, if taken
                  without the express written consent of Executive:

                                    A. any material change by the Company in
                           Executive's functions, duties, or responsibilities
                           which change would cause Executive's position with
                           the Company to become of less dignity,
                           responsibility, importance, or scope from the
                           position and attributes that applied to Executive
                           immediately prior to the Change in Control;

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                                    B. a 5% or more reduction in Executive's
                           base salary, other than a reduction effected as part
                           of an across-the-board reduction affecting all
                           executive employees of the Company;

                                    C. any material failure by the Company to
                           comply with any of the provisions of this Agreement
                           (or of any employment agreement between the parties);

                                    D. the Company's requiring Executive to be
                           based at any office or location more than 45 miles
                           from the home at which the Executive resides on the
                           date immediately preceding the Change in Control,
                           except for travel reasonably required in the
                           performance of Executive's responsibilities and
                           commensurate with the amount of travel required of
                           Executive prior to the Change in Control; or

                                    E. any failure by the Company to obtain the
                           express assumption of this Agreement by any successor
                           or assign of the Company.

                                    Executive's right to terminate employment
                           for Good Reason pursuant to this subsection 4(b)(I)
                           shall not be affected by Executive's incapacity due
                           to physical or mental illness.

                           (ii) Remedy by Company. If Executive gives the
                  Company a Notice of Termination which states that the basis
                  for Executive's termination of employment is Good Reason, the
                  Company shall have ten days after receipt of such Notice to
                  remedy the facts and circumstances which provided Good Reason.
                  Executive shall make a good faith reasonable determination
                  immediately after such ten-day period whether such facts and
                  circumstances have been remedied and shall communicate such
                  determination in writing to the Company. If Executive
                  determines that adequate remedy has not occurred, then the
                  initial Notice of Termination shall remain in effect.

                           (iii) Determination by Executive Presumed Correct.
                  Any determination by Executive pursuant to this Section 4(b)
                  that Good Reason exists for Executive's termination of
                  employment and that adequate remedy has not occurred shall be
                  presumed correct and shall govern unless the party contesting
                  the determination shows by a clear preponderance of the
                  evidence that it was not a good faith reasonable
                  determination.

                           (iv) Severance Payment Made Notwithstanding Dispute.
                  Notwithstanding any dispute concerning whether Good Reason
                  exists for termination of employment or whether adequate
                  remedy has occurred, the Company shall immediately pay to
                  Executive, as specified in Section 5, any amounts otherwise
                  due under this Agreement. Executive may be required to repay
                  such amounts to the Company if any such dispute is finally
                  determined adversely to Executive.

                  (c) Notice of Termination. Any termination of Executive's
         employment by the Company or by Executive hereunder shall be
         communicated by a Notice of Termination to the other party hereto. For
         purposes of this Agreement, a "Notice of Termination" shall mean a
         written notice which shall indicate the specific termination provisions
         in this Agreement relied upon any which sets forth (i) in reasonable
         detail the facts and circumstances claimed to provide a basis for
         termination of Executive's employment under the provision so indicated
         and (ii) the date of Executive's termination of employment, which shall
         be no earlier than 10 days after such Notice is received by the other
         party. Any purported termination of the Executive's employment by the
         Company which is not effected pursuant to a Notice of Termination
         satisfying the requirements of this Agreement shall not be effective.
         In the case of a termination for Cause, the Notice of Termination shall
         also satisfy the requirements set forth in Section 4(a)(i).

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         5. Severance Payment Upon Termination of Employment. If Executive's
employment with the Company is terminated during the term of this Agreement and
after a Change in Control (a) by the Company other than for Cause, or (b) by
Executive for Good Reason, then Executive shall be entitled to the following:

                  (a) Lump-Sum Severance Payment. In lieu of any further salary
         payments to the Executive for periods subsequent to the Date of
         Termination, the Company shall pay to the Executive a lump sum
         severance payment, in cash, equal to three (3) (or, if less, the number
         of years, including fractions, from the date of Termination until the
         Executive would have reached age sixty-five (65)) times the sum of (a)
         the Executive's Annual Base Salary in effect on date of termination and
         (b) the Executive's most recent Annual Bonus. If the most recent Annual
         Bonus was a stock option or a stock grant, the value of the bonus will
         be deemed to be the number of option shares times the closing price of
         the Company's Common Stock for the 20 trading days prior to
         Termination.

                  (b) Continued Benefits. For a thirty-six (36) month period
         (or, if less, the number of months from the Date of Termination until
         the Executive would have reached age sixty-five (65)) after the Date of
         Termination, the Company shall provide the Executive with life
         insurance, health, disability and other welfare benefits ("Welfare
         Benefits") substantially similar in all respects to those which the
         Executive is receiving immediately prior to the Notice of Termination
         (without giving effect to any reduction in such benefits subsequent to
         the Potential Change in Control preceding the Change in Control or the
         Change in Control which reduction constitutes or may constitute God
         Reason). Benefits otherwise receivable by an Executive pursuant to this
         Section shall be reduced to the extent substantially similar benefits
         are actually received by or made available to the Executive by any
         other employer during the same time period for which such benefits
         would be provided pursuant to this Section at a cost to the Executive
         that is commensurate with the cost incurred by the Executive
         immediately prior to the Executive's Date of Termination (without
         giving effect to any increase in costs paid by the Executive after the
         Potential Change in Control preceding the Change in Control or the
         Change in Control which constitutes or may constitute Good Reason);
         provided, however, that if the Executive becomes employed by a new
         employer which maintains a medical plan that either (i) does not cover
         the Executive or a family member or dependent with respect to a
         preexisting condition which was covered under the applicable Company
         medical plan, or (ii) does not cover the Executive or a family member
         or dependent for a designated waiting period, the Executive's coverage
         under the applicable Company medical plan shall continue (but shall be
         limited in the event of noncoverage due to a preexisting condition, to
         such preexisting condition) until the earlier of the end of the
         applicable period of noncoverage under the new employer's plan or the
         third anniversary of the Executive's Date of Termination. The Executive
         agrees to report to the Company any coverage and benefits actually
         received by the Executive or made available to the Executive from such
         other employer(s). The Executive shall be entitled to elect to change
         his level of coverage and/or his choice of coverage options (such as
         Executive only or family medical coverage) with respect to the Welfare
         Benefits to be provided by the Company to the Executive to the same
         extent that actively employed senior executives of the Company are
         permitted to make such changes; provided, however, that in the event of
         any such changes the Executive shall pay the amount of any cost
         increase that would actually be paid by an actively employed executive
         of the Company by reason of making the same change in his level of
         coverage or coverage options.

                  (c) Gross-Up Payment. In the event that the Executive becomes
         entitled to the Severance Benefits or any other benefits or payments
         under this Agreement (other than pursuant to this Section) by reason of
         the accelerated vesting of stock options thereunder (together, the
         "Total Benefits"), and in the event that any of the Total Benefits will
         be subject to the Excise Tax, the Company shall pay to the Executive an
         additional amount (the "Gross-Up Payment") such that the net amount
         retained by the Executive, after deduction of any Excise Tax on the
         Total Benefits and any federal, state and local income tax, Excise Tax
         and FICA and Medicare withholding taxes upon the payment provided for
         by this Section, shall be equal to the Total Benefits.

                  For purposes of determining whether any of the Total Benefits
         will be subject to the Excise Tax and the amount of such Excise Tax,
         (i) any other payments or benefits received or to be received by the
         Executive

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         in connection with a Change in Control or the Executive's termination
         of employment (whether pursuant to the terms of this Agreement or any
         other agreement, plan or arrangement with the Company, any Person whose
         actions result in a Change in Control or any Person affiliated with the
         Company or such Person) shall be treated as "parachute payments" within
         the meaning of Section 280G(b)(2) of the Cod, and all "excess parachute
         payments" within the meaning the Section 280G(b)(1) shall be treated as
         subject to the Excise Tax, unless in the opinion of tax counsel ("Tax
         Counsel") selected by the Company's independent auditors and acceptable
         to the Executive, such other payments or benefits (in whole or in part)
         do not constitute parachute payments, or such excess parachute payments
         (in whole or in part) represent reasonable compensation for services
         actually rendered within the meaning of Section 280G(b)(4) of the Code
         in excess of the Base Amount, or are otherwise not subject to the
         Excise Tax, (ii) the amount of the Total Benefits which shall be
         treated as subject to the Excise Tax shall be equal to the lesser of
         (A) the total amount of the Total Benefits reduced by the amount of
         such Total Benefits that in the opinion of Tax Counsel are not
         parachute payments, or (B) the amount of excess parachute payments
         within the meaning of Section 280G(b)(1) (after applying clause (i),
         above), and (iii) the value of any non-cash benefits or any deferred
         payment or benefit shall be determined by the Company's independent
         auditors in accordance with the principles of sections 280G(d)(3) and
         (4) of the Code. For purposes of determining the amount of the Gross-Up
         Payment, the Executive shall be deemed to pay federal income taxes at
         the highest marginal rate of federal income taxation in the calendar
         year in which the Gross-Up Payment is to be made and state and local
         income taxes at the highest marginal rate of taxation in the state and
         locality of the Executive's residence on the Date of Termination, net
         of the reduction in federal income taxes which could be obtained from
         deduction of such state and local taxes (calculated by assuming that
         any reduction under Section 68 of the Code in the amount of itemized
         deductions allowable to the Executive applies first to reduce the
         amount of such state and local income taxes that would otherwise be
         deductible by the Executive).

         In the event that the Excise Tax is subsequently determined to be less
than the amount taken into account hereunder at the time of termination of the
Executive's employment, the Executive shall repay to the Company, at the time
that the amount of such reduction in Excise Tax is finally determined, the
portion of the Gross-Up Payment attributable to such reduction (plus that
portion of the Gross-Up Payment attributable to the Excise Tax, federal, state
and local income taxes and FICA and Medicare withholding taxes imposed on the
portion of the Gross-Up Payment being repaid by the Executive to the extent that
such repayment results in a reduction in Excise Tax, FICA and Medicare
withholding taxes and/or federal, state or local income taxes) plus interest on
the amount of such repayment at the rate provided in Section 1274(b)(2)(B) of
the Code. In the event that the Excise Tax is determined to exceed the amount
taken into account hereunder at the time of the termination of the Executive's
employment (including by reason of any payment the existence or amount of which
cannot be determined at the time of the Gross-Up Payment), the Company shall
make an additional Gross-Up Payment, determined as previously described, to the
Executive in respect to such excess (plus any interest, penalties or additions
payable by the Executive with respect to such excess) at the time that the
amount of such excess is finally determined.

                  (d) Timing of Payments. The payments provided for in Sections
         5(a) and 5(c) shall be made not later than the fifth (5th) day
         following the Date of Termination; provided, however, that if the
         amounts of such payments cannot be finally determined on or before such
         day, the Company shall pay to the Executive on such day an estimate, as
         determined in good faith by the Company, of the minimum amount of such
         payments and shall pay the remainder of such payments (together with
         interest at the rate provided in Section 1274(b)(2)(B) of the Code from
         the firth (5th) day following the Date of Termination to the payment of
         such remainder) as soon as the amount thereof can be determined but in
         no event later than the thirtieth (30th) day after the Date of
         Termination. In the event that the amount of the estimated payments
         exceeds the amount subsequently determined to have been due, such
         excess shall constitute a loan by the Company to the Executive, payable
         on the fifth (5th) business day after demand by the Company (together
         with interest at the rate provided in Section 1274(b)(2)(B) of the Code
         from the fifth (5th) day following the Date of Termination to the
         repayment of such excess).

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         6. Reimbursement of Legal Costs. The Company shall pay to the Executive
all legal fees and expenses incurred by the Executive as a result of a
termination which entitles the Executive to any payments under this Agreement
including all such fees and expenses, if any, incurred in contesting or
disputing any Notice of Intent to Terminate under Section 4(a) hereof or in
seeking to obtain or enforce any right or benefit provided by this Agreement or
in connection with any tax audit or proceeding to the extent attributable to the
application of Section 4999 of the Code to any payment or benefit provide
hereunder. Such payments shall be made within five (5) business days after
delivery of the Executive's respective written requests for payment accompanied
by such evidence of fees and expenses incurred as the Company reasonably may
require.

         7. Damages. Executive shall not be required to mitigate damages with
respect to the amount of any payment provided under this Agreement by seeking
other employment or otherwise, nor shall the amount of any payment provided
under this Agreement be reduced by retirement benefits, deferred compensation or
any compensation earned by Executive as a result of employment by another
employer.

         8. Successor to Company. The Company shall require any successor or
assign (whether direct or indirect, by purchase, merger, consolidation or
otherwise) to all or substantially all of the business and/or assets of the
Company, by agreement in form and substance satisfactory to Executive,
expressly, absolutely and unconditionally to assume and agree to perform this
Agreement in the same manner and to the same extent that the Company would be
required to perform it if no such succession or assignment had taken place. A
used in this Agreement, "Company" shall mean the Company as hereinbefore defined
and any successor or assign to its business and/or assets as aforesaid which
executes and delivers the agreement provided for in this section or which
otherwise becomes bound by all the terms and provisions of this Agreement by
operation of law.

         9. Heirs of Executive. This Agreement shall inure to the benefit of and
be enforceable by Executive's personal and legal representatives, executors,
administrators, successors, heirs, distributees, devisees and legatees. If
Executive should die while any amounts are still payable to Executive hereunder,
all such amounts, unless otherwise provided herein, shall be paid in accordance
with the terms of this Agreement to Executive's devisee, legatee, or other
designee or, if there be so much designee, to Executive's estate.

         10. Arbitration. Any dispute, controversy or claim arising under or in
connection with this Agreement, or the breach thereof, shall be settled
exclusively by arbitration in accordance with the Rules of the American
Arbitration Association then in effect. Judgment upon the award rendered by the
arbitrator(s) may be entered in any court of competent jurisdiction. Any
arbitration held pursuant to this section in connection with Executive's
termination of employment shall take place in Houston, Texas at the earliest
possible date. If any proceeding is necessary to enforce or interpret the terms
of this Agreement, or to recover damages for breach thereof, the prevailing
party shall be entitled to reasonable attorneys' fees and necessary costs and
disbursements, not to exceed in the aggregate one percent (1%) of the net worth
of the other party, in addition to any other relief to which he or it may be
entitled.

         11. Notice. For purposes of this Agreement, notices and all other
communications provided for in this Agreement shall be in writing and shall be
deemed to have been duly given when delivered by messenger or in person, or when
mailed by United States registered mail, return receipt requested, postage
prepaid, as follows:

         If to the Company:         Texas Biotechnology Corporation
                                    7000 Fannin, 20th Floor
                                    Houston, Texas 77030
                                    Attention: President

         If to the Executive:
                                    --------------------------------------------
                                    c/o Texas Biotechnology Corporation
                                    7000 Fannin, 20th Floor
                                    Houston, Texas 77030

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or such other address as either party may have furnished to the other in writing
in accordance herewith, except that notices of change of address shall be
effective only upon receipt.

         12.      General Provisions.

                  (a) Executive's rights and obligations under this Agreement
         shall not be transferable by assignment or otherwise, nor shall
         Executive's rights be subject to encumbrance or subject to the claims
         of the Company's creditors. Nothing in this Agreement shall prevent the
         consolidation of the Company with, or its merger into, any other
         corporation, or the sale by the Company of all or substantially all of
         its properties or assets; and this Agreement shall inure to the benefit
         of, be binding upon and be enforceable by, any successor surviving or
         resulting corporation, or other entity to which such assets shall be
         transferred. This Agreement shall not be terminated by the voluntary or
         involuntary dissolution of the Company.

                  (b) This Agreement and any Employment Agreement with Executive
         plus terms of any stock option plans or grants constitutes the entire
         agreement between the parties hereto in respect to the rights and
         obligations of the parties following a Change in Control. This
         Agreement supersedes and replaces all prior oral and written
         agreements, understandings, commitments, and practices between the
         parties (whether or not fully performed by Executive prior to the date
         hereof), which shall be of no further force or effect.

                  (c) The provisions of this Agreement shall be regarded as
         divisible, and if any of said provisions or any part thereof are
         declared invalid or unenforceable by a court of competent jurisdiction,
         the validity and enforceability of the remainder of such provisions or
         parts thereof and the applicability thereof shall not be affected
         thereby.

                  (d) This Agreement may not be amended or modified except by a
         written instrument executed by the Company and Executive.

                  (e) This Agreement and the rights and obligations hereunder
         shall be governed by and construed in accordance with the laws of the
         State of Texas.

         IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first above written.

                                                TEXAS BIOTECHNOLOGY CORPORATION,
                                                A Delaware Corporation

                                                By:
                                                   -----------------------------

                                                --------------------------------
                                                           Executive

                                       8<PAGE>
                                                                   EXHIBIT 10.26

                              TERMINATION AGREEMENT

         THIS TERMINATION AGREEMENT, dated as of __________, ______ is made and
entered into by and between Texas Biotechnology Corporation, a Delaware
corporation with its principal office at 7000 Fannin, Houston, Texas 77030 (the
"Company"), and __________________ ("Executive").

                                   RECITALS

         A. The Company and the Executive have entered into an Employment
Agreement dated ___________ concerning the employment of the Executive as the
___________ and _______________________ of the Company.

         B. Company desires to enter into an agreement with Executive whereby
severance benefits will be paid to Executive on a change in control of the
Company and consequent actual or constructive termination of Executive's
employment.

         C. This Agreement sets forth the severance benefits which the Company
agrees that it will pay to the Executive if Executive's employment with the
Company terminates under one of the circumstances described herein following a
Change in Control of the Company.

         NOW, THEREFORE, in consideration of the foregoing premises and the
mutual covenants contained herein, the parties hereto agree as follows:

         1. Term of Agreement. This Agreement shall be effective immediately on
the date hereof and shall continue in effect through December 31, _____;
provided, however, that commencing on January 1, _____ and each January 1
thereafter, the term of this Agreement shall automatically be extended for one
additional year unless not later than September 30 of the preceding year, the
Company shall have given notice that it does not wish to extend this Agreement;
provided, further, that notwithstanding any such notice by the Company not to
extend this Agreement shall automatically be extended for 24 months beyond the
term provided herein if a Change in Control, as defined in Section 3 of this
Agreement has occurred during the term of this Agreement.

         2. Effect on Employment Rights. This Agreement is not part of the
Employment Agreement or any other employment agreement that the Company and
Executive may have entered. Nothing in this Agreement shall confer upon
Executive any right to continue in the employ of the Company or interfere with
or restrict in any way the rights of the Company, which are hereby expressly
reserved, to terminate for any reason, with or without cause.

         Executive agrees that, subject to the terms and conditions of this
Agreement, in the event of a potential change in control of the Company (as
defined below), Executive will remain in the employ of the Company during the
pendency of any such potential change in control and for a period of one year
after the occurrence of an actual Change in Control. For this purpose, a
"potential change in control of the Company" shall be deemed to have occurred if
(a) the Company enters into an agreement the consummation of which would result
in the occurrence of a Change in Control, (b) any person (including the Company)
publicly announces an intention to take or consider taking action which if
consummated would constitute a Change in Control or (c) the Board of Directors
of the Company (the "Board") adopts a resolution to the effect that a potential
change in control of the Company has occurred.

         3. Change in Control. For purposes of this Agreement, a "Change in
Control" of the Company shall be deemed to have occurred if any of the events
set forth in any one of the following paragraphs shall occur:

<PAGE>

                  (a) any "person" (as defined in section 3(a)(9) of the
         Securities Exchange Act of 1934, as amended (the "Exchange Act") and as
         such term is modified in sections 13(d) and 14(d) of the Exchange Act),
         excluding the Company or any of its subsidiaries, a trustee or any
         fiduciary holding securities under an employee benefit plan of the
         Company of any of its subsidiaries, an underwriter temporarily holding
         securities pursuant to an offering of such securities or a corporation
         owned, directly or indirectly, by stockholders of the Company in
         substantially the same proportions as their ownership of the Company,
         is or becomes the "beneficial owner" (as defined in Rule 13d-3 under
         the Exchange Act), directly or indirectly, of securities of the Company
         representing 30% or more of the combined voting power of the Company's
         then outstanding securities; or

                  (b) during any period of not more than two consecutive years,
         individuals who at the beginning of much period constitute the Board
         and any new director (other than a director designated by a Person who
         has entered into an agreement with the Company to effect a transaction
         described in clause (a), (c) or (d) of this paragraph) whose election
         by the Board or nomination for election by the Company's stockholders
         was approved by a vote of at least two-thirds (2/3) of the directors
         then still in office who either were directors at the beginning of the
         period or whose election or nomination for election was previously so
         approved, cease for any reason to constitute a majority thereof; or

                  (c) the shareholders of the Company approve a merger or
         consolidation of the Company with any other corporation, other than (i)
         a merger or consolidation which would result in the voting securities
         of the Company outstanding immediately prior thereto continuing to
         represent (either by remaining outstanding or by being converted into
         voting securities of the surviving entity), in combination with the
         ownership of any trustee or other fiduciary holder of securities under
         an employee benefit plan of the Company, at least 50% of the combined
         voting power of the voting securities of the Company or such surviving
         entity outstanding immediately after such merger or consolidation, or
         (ii) a merger or consolidation effected to implement a recapitalization
         of the Company (or similar transaction) in which no person acquires
         more than 50% of the combined voting power of the Company's then
         outstanding securities; or

                  (d) the shareholders of the Company approve a plan of complete
         liquidation of the Company or an agreement for the sale or disposition
         by the Company of all or substantially all of the Company's assets.

         Notwithstanding the foregoing, no Change in Control shall be deemed to
         have occurred if there is consummated any transaction or series of
         integrated transactions immediately following which, in the judgment of
         the Compensation Committee of the Board, the holders of the Company's
         Common Stock immediately prior to such transaction or series of
         transactions continue to have the same proportionate ownership in an
         entity which owns all or substantially all of the assets of the Company
         immediately prior to such transaction or series of transactions. Except
         during a potential change of control of the Company (as defined in
         Section 2 above), the Board may (i) deem any other corporate event
         affecting the Company (other than those described in paragraph 3(a)-(d)
         above) to be a "Change of Control", and (ii) may amend this provision
         and the definition of "Change of Control" in connection with an
         identical amendment being made to the Termination Agreements entered
         into by the Company and all of its executives.

         4. Termination of Employment Following a Change in Control. Executive
shall be entitled to the benefits provided in Section 5 hereof upon the
subsequent termination of Executive's employment by the Company within two years
after a Change in Control which occurs during the term of this Agreement,
provided such termination is (a) by the Company other than for cause, as defined
below, or (b) by Executive for Good Reason, as defined below. Executive shall
not be entitled to the benefits of Section 5, any other provision hereof to the
contrary notwithstanding, if Executive's employment terminates: (i) pursuant to
Executive retiring at age 65, (ii) by reason of Executive's total and permanent
disability, or (iii) by reason or Executive's death. As used herein, "total and
permanent disability" means an illness or other disability which prevents the
Executive from discharging his responsibilities under the Employment Agreement
for a period of 180 consecutive calendar days, or an aggregate of 180 calendar
days in any calendar year, all as determined in good faith by the Board (or a
committee thereof).

                                       2
<PAGE>
                  (a)      Cause.

                           (i) Definition. Termination by the Company of
                  Executive's employment for Cause shall mean termination upon
                  (i) the conviction (or plea of nolo contendere or equivalent
                  plea) of the Executive of a felony (which, through lapse of
                  time or otherwise, is not subject to appeal), (ii) the
                  Executive having engaged in intentional misconduct causing a
                  material violation by the Company of any state or federal
                  laws, (iii) the Executive having engaged in a theft of
                  corporate funds or corporate assets or in an act of fraud upon
                  the Company, (iv) an act of personal dishonesty taken by the
                  Executive that was intended to result in personal enrichment
                  of the Executive at the expense of the Company, (v) the
                  Executive's refusal, without proper legal cause, to perform
                  his duties and responsibilities as President and Chief
                  Executive Officer or (vi) the Executive's engaging in
                  activities which would (A) constitute a breach of any term of
                  the Employment Agreement, the Company's Code of Ethics, the
                  Company's policies regarding trading in the Common Stock or
                  any other applicable policies, rules or regulations of the
                  Company, or (B) result in a material injury to the business,
                  condition (financial or otherwise), results of operations or
                  prospects of the Company (as determined in good faith by the
                  Board or a committee thereof). For purposes of this definition
                  of "Cause", the term "Company" shall mean the Company and/or
                  its subsidiaries and affiliates. No act, or failure to act, on
                  Executive's part shall be considered "intentional" unless
                  done, or omitted to be done, by Executive not in good faith
                  and without reasonable belief that Executive's action or
                  omission was in the best interest of the Company or its
                  subsidiaries. Notwithstanding the foregoing, Executive shall
                  not be deemed to have been terminated for Cause unless and
                  until there shall have been delivered to Executive a copy of a
                  resolution duly adopted by the affirmative vote of not less
                  than three quarters of the entire membership of the Board at a
                  meeting of the Board called and held for the purpose of making
                  a determination of whether Cause for termination exists (after
                  reasonable notice to Executive and an opportunity for
                  Executive to be heard before the Board), finding that in the
                  good faith opinion of the Board Executive was guilty of
                  misconduct as set forth above in this subsection 4(a)(i) and
                  specifying the particulars thereof in detail.

                           (ii) Remedy by Executive. If the Company gives
                  Executive a Notice of Termination which states that the basis
                  for terminating Executive's employment is Cause, Executive
                  shall have ten days after receipt of such Notice to remedy the
                  facts and circumstances which provided Cause. The Board (or
                  any duly authorized Committee thereof) shall make a good faith
                  reasonable determination immediately after such ten-day period
                  whether such facts and circumstances have been remedied and
                  shall communicate such determination in writing to Executive.
                  If the Board determines that an adequate remedy has not
                  occurred, then the initial Notice of Termination shall remain
                  in effect.

                  (b) Good Reason. After a Change in Control, Executive may
         terminate employment with the Company at any time during the term of
         this Agreement if Executive has made a good faith reasonable
         determination that Good Reason exists for this termination.

                           (i) Definition. For purposes of this Agreement, "Good
                  Reason" shall mean any of the following actions, if taken
                  without the express written consent of Executive:

                                    A. any material change by the Company in
                           Executive's functions, duties, or responsibilities
                           which change would cause Executive's position with
                           the Company to become of less dignity,
                           responsibility, importance, or scope from the
                           position and attributes that applied to Executive
                           immediately prior to the Change in Control;

                                    B. a 5% or more reduction in Executive's
                           base salary, other than a reduction effected as part
                           of an across-the-board reduction affecting all
                           executive employees of the Company;

                                       3
<PAGE>

                                    C. any material failure by the Company to
                           comply with any of the provisions of this Agreement
                           (or of any employment agreement between the parties);

                                    D. the Company's requiring Executive to be
                           based at any office or location more than 45 miles
                           from the home at which the Executive resides on the
                           date immediately preceding the Change in Control,
                           except for travel reasonably required in the
                           performance of Executive's responsibilities and
                           commensurate with the amount of travel required of
                           Executive prior to the Change in Control; or

                                    E. any failure by the Company to obtain the
                           express assumption of this Agreement by any successor
                           or assign of the Company.

                                    Executive's right to terminate employment
                           for Good Reason pursuant to this subsection 4(b)(I)
                           shall not be affected by Executive's incapacity due
                           to physical or mental illness.

                           (ii) Remedy by Company. If Executive gives the
                  Company a Notice of Termination which states that the basis
                  for Executive's termination of employment is Good Reason, the
                  Company shall have ten days after receipt of such Notice to
                  remedy the facts and circumstances which provided Good Reason.
                  Executive shall make a good faith reasonable determination
                  immediately after such ten-day period whether such facts and
                  circumstances have been remedied and shall communicate such
                  determination in writing to the Company. If Executive
                  determines that adequate remedy has not occurred, then the
                  initial Notice of Termination shall remain in effect.

                           (iii) Determination by Executive Presumed Correct.
                  Any determination by Executive pursuant to this Section 4(b)
                  that Good Reason exists for Executive's termination of
                  employment and that adequate remedy has not occurred shall be
                  presumed correct and shall govern unless the party contesting
                  the determination shows by a clear preponderance of the
                  evidence that it was not a good faith reasonable
                  determination.

                           (iv) Severance Payment Made Notwithstanding Dispute.
                  Notwithstanding any dispute concerning whether Good Reason
                  exists for termination of employment or whether adequate
                  remedy has occurred, the Company shall immediately pay to
                  Executive, as specified in Section 5, any amounts otherwise
                  due under this Agreement. Executive may be required to repay
                  such amounts to the Company if any such dispute is finally
                  determined adversely to Executive.

                  (c) Notice of Termination. Any termination of Executive's
         employment by the Company or by Executive hereunder shall be
         communicated by a Notice of Termination to the other party hereto. For
         purposes of this Agreement, a "Notice of Termination" shall mean a
         written notice which shall indicate the specific termination provisions
         in this Agreement relied upon any which sets forth (i) in reasonable
         detail the facts and circumstances claimed to provide a basis for
         termination of Executive's employment under the provision so indicated
         and (ii) the date of Executive's termination of employment, which shall
         be no earlier than 10 days after such Notice is received by the other
         party. Any purported termination of the Executive's employment by the
         Company which is not effected pursuant to a Notice of Termination
         satisfying the requirements of this Agreement shall not be effective.
         In the case of a termination for Cause, the Notice of Termination shall
         also satisfy the requirements set forth in Section 4(a)(i).

         5. Severance Payment Upon Termination of Employment. If Executive's
employment with the Company is terminated during the term of this Agreement and
after a Change in Control (a) by the Company other than for Cause, or (b) by
Executive for Good Reason, then Executive shall be entitled to the following:

                                       4
<PAGE>
                  (a) Lump-Sum Severance Payment. In lieu of any further salary
         payments to the Executive for periods subsequent to the Date of
         Termination, the Company shall pay to the Executive a lump sum
         severance payment, in cash, equal to one and a half (1.5) (or, if less,
         the number of years, including fractions, from the date of Termination
         until the Executive would have reached age sixty-five (65)) times the
         sum of (a) the Executive's Annual Base Salary in effect on date of
         termination and (b) the Executive's most recent Annual Bonus. If the
         most recent Annual Bonus was a stock option or a stock grant, the value
         of the bonus will be deemed to be the number of option shares times the
         closing price of the Company's Common Stock for the 20 trading days
         prior to Termination.

                  (b) Continued Benefits. For an eighteen (18) month period (or,
         if less, the number of months from the Date of Termination until the
         Executive would have reached age sixty-five (65)) after the Date of
         Termination, the Company shall provide the Executive with life
         insurance, health, disability and other welfare benefits ("Welfare
         Benefits") substantially similar in all respects to those which the
         Executive is receiving immediately prior to the Notice of Termination
         (without giving effect to any reduction in such benefits subsequent to
         the Potential Change in Control preceding the Change in Control or the
         Change in Control which reduction constitutes or may constitute God
         Reason). Benefits otherwise receivable by an Executive pursuant to this
         Section shall be reduced to the extent substantially similar benefits
         are actually received by or made available to the Executive by any
         other employer during the same time period for which such benefits
         would be provided pursuant to this Section at a cost to the Executive
         that is commensurate with the cost incurred by the Executive
         immediately prior to the Executive's Date of Termination (without
         giving effect to any increase in costs paid by the Executive after the
         Potential Change in Control preceding the Change in Control or the
         Change in Control which constitutes or may constitute Good Reason);
         provided, however, that if the Executive becomes employed by a new
         employer which maintains a medical plan that either (i) does not cover
         the Executive or a family member or dependent with respect to a
         preexisting condition which was covered under the applicable Company
         medical plan, or (ii) does not cover the Executive or a family member
         or dependent for a designated waiting period, the Executive's coverage
         under the applicable Company medical plan shall continue (but shall be
         limited in the event of noncoverage due to a preexisting condition, to
         such preexisting condition) until the earlier of the end of the
         applicable period of noncoverage under the new employer's plan or the
         third anniversary of the Executive's Date of Termination. The Executive
         agrees to report to the Company any coverage and benefits actually
         received by the Executive or made available to the Executive from such
         other employer(s). The Executive shall be entitled to elect to change
         his level of coverage and/or his choice of coverage options (such as
         Executive only or family medical coverage) with respect to the Welfare
         Benefits to be provided by the Company to the Executive to the same
         extent that actively employed senior executives of the Company are
         permitted to make such changes; provided, however, that in the event of
         any such changes the Executive shall pay the amount of any cost
         increase that would actually be paid by an actively employed executive
         of the Company by reason of making the same change in his level of
         coverage or coverage options.

                  (c) Gross-Up Payment. In the event that the Executive becomes
         entitled to the Severance Benefits or any other benefits or payments
         under this Agreement (other than pursuant to this Section) by reason of
         the accelerated vesting of stock options thereunder (together, the
         "Total Benefits"), and in the event that any of the Total Benefits will
         be subject to the Excise Tax, the Company shall pay to the Executive an
         additional amount (the "Gross-Up Payment") such that the net amount
         retained by the Executive, after deduction of any Excise Tax on the
         Total Benefits and any federal, state and local income tax, Excise Tax
         and FICA and Medicare withholding taxes upon the payment provided for
         by this Section, shall be equal to the Total Benefits.

                  For purposes of determining whether any of the Total Benefits
         will be subject to the Excise Tax and the amount of such Excise Tax,
         (i) any other payments or benefits received or to be received by the
         Executive in connection with a Change in Control or the Executive's
         termination of employment (whether pursuant to the terms of this
         Agreement or any other agreement, plan or arrangement with the Company,
         any Person whose actions result in a Change in Control or any Person
         affiliated with the Company or such Person) shall be treated as
         "parachute payments" within the meaning of Section 280G(b)(2) of the
         Cod, and all "excess parachute payments" within the meaning the Section
         280G(b)(1) shall be treated as subject to the Excise Tax, unless in

                                       5
<PAGE>

         the opinion of tax counsel ("Tax Counsel") selected by the Company's
         independent auditors and acceptable to the Executive, such other
         payments or benefits (in whole or in part) do not constitute parachute
         payments, or such excess parachute payments (in whole or in part)
         represent reasonable compensation for services actually rendered within
         the meaning of Section 280G(b)(4) of the Code in excess of the Base
         Amount, or are otherwise not subject to the Excise Tax, (ii) the amount
         of the Total Benefits which shall be treated as subject to the Excise
         Tax shall be equal to the lesser of (A) the total amount of the Total
         Benefits reduced by the amount of such Total Benefits that in the
         opinion of Tax Counsel are not parachute payments, or (B) the amount of
         excess parachute payments within the meaning of Section 280G(b)(1)
         (after applying clause (i), above), and (iii) the value of any non-cash
         benefits or any deferred payment or benefit shall be determined by the
         Company's independent auditors in accordance with the principles of
         sections 280G(d)(3) and (4) of the Code. For purposes of determining
         the amount of the Gross-Up Payment, the Executive shall be deemed to
         pay federal income taxes at the highest marginal rate of federal income
         taxation in the calendar year in which the Gross-Up Payment is to be
         made and state and local income taxes at the highest marginal rate of
         taxation in the state and locality of the Executive's residence on the
         Date of Termination, net of the reduction in federal income taxes which
         could be obtained from deduction of such state and local taxes
         (calculated by assuming that any reduction under Section 68 of the Code
         in the amount of itemized deductions allowable to the Executive applies
         first to reduce the amount of such state and local income taxes that
         would otherwise be deductible by the Executive).

         In the event that the Excise Tax is subsequently determined to be less
than the amount taken into account hereunder at the time of termination of the
Executive's employment, the Executive shall repay to the Company, at the time
that the amount of such reduction in Excise Tax is finally determined, the
portion of the Gross-Up Payment attributable to such reduction (plus that
portion of the Gross-Up Payment attributable to the Excise Tax, federal, state
and local income taxes and FICA and Medicare withholding taxes imposed on the
portion of the Gross-Up Payment being repaid by the Executive to the extent that
such repayment results in a reduction in Excise Tax, FICA and Medicare
withholding taxes and/or federal, state or local income taxes) plus interest on
the amount of such repayment at the rate provided in Section 1274(b)(2)(B) of
the Code. In the event that the Excise Tax is determined to exceed the amount
taken into account hereunder at the time of the termination of the Executive's
employment (including by reason of any payment the existence or amount of which
cannot be determined at the time of the Gross-Up Payment), the Company shall
make an additional Gross-Up Payment, determined as previously described, to the
Executive in respect to such excess (plus any interest, penalties or additions
payable by the Executive with respect to such excess) at the time that the
amount of such excess is finally determined.

                  (d) Timing of Payments. The payments provided for in Sections
         5(a) and 5(c) shall be made not later than the fifth (5th) day
         following the Date of Termination; provided, however, that if the
         amounts of such payments cannot be finally determined on or before such
         day, the Company shall pay to the Executive on such day an estimate, as
         determined in good faith by the Company, of the minimum amount of such
         payments and shall pay the remainder of such payments (together with
         interest at the rate provided in Section 1274(b)(2)(B) of the Code from
         the firth (5th) day following the Date of Termination to the payment of
         such remainder) as soon as the amount thereof can be determined but in
         no event later than the thirtieth (30th) day after the Date of
         Termination. In the event that the amount of the estimated payments
         exceeds the amount subsequently determined to have been due, such
         excess shall constitute a loan by the Company to the Executive, payable
         on the fifth (5th) business day after demand by the Company (together
         with interest at the rate provided in Section 1274(b)(2)(B) of the Code
         from the fifth (5th) day following the Date of Termination to the
         repayment of such excess).

         6. Reimbursement of Legal Costs. The Company shall pay to the Executive
all legal fees and expenses incurred by the Executive as a result of a
termination which entitles the Executive to any payments under this Agreement
including all such fees and expenses, if any, incurred in contesting or
disputing any Notice of Intent to Terminate under Section 4(a) hereof or in
seeking to obtain or enforce any right or benefit provided by this Agreement or
in connection with any tax audit or proceeding to the extent attributable to the
application of Section 4999 of the Code to any payment or benefit provide
hereunder. Such payments shall be made within five (5) business days after
delivery of the Executive's

                                       6
<PAGE>

respective written requests for payment accompanied by such evidence of fees and
expenses incurred as the Company reasonably may require.

         7. Damages. Executive shall not be required to mitigate damages with
respect to the amount of any payment provided under this Agreement by seeking
other employment or otherwise, nor shall the amount of any payment provided
under this Agreement be reduced by retirement benefits, deferred compensation or
any compensation earned by Executive as a result of employment by another
employer.

         8. Successor to Company. The Company shall require any successor or
assign (whether direct or indirect, by purchase, merger, consolidation or
otherwise) to all or substantially all of the business and/or assets of the
Company, by agreement in form and substance satisfactory to Executive,
expressly, absolutely and unconditionally to assume and agree to perform this
Agreement in the same manner and to the same extent that the Company would be
required to perform it if no such succession or assignment had taken place. A
used in this Agreement, "Company" shall mean the Company as hereinbefore defined
and any successor or assign to its business and/or assets as aforesaid which
executes and delivers the agreement provided for in this section or which
otherwise becomes bound by all the terms and provisions of this Agreement by
operation of law.

         9. Heirs of Executive. This Agreement shall inure to the benefit of and
be enforceable by Executive's personal and legal representatives, executors,
administrators, successors, heirs, distributees, devisees and legatees. If
Executive should die while any amounts are still payable to Executive hereunder,
all such amounts, unless otherwise provided herein, shall be paid in accordance
with the terms of this Agreement to Executive's devisee, legatee, or other
designee or, if there be so much designee, to Executive's estate.

         10. Arbitration. Any dispute, controversy or claim arising under or in
connection with this Agreement, or the breach thereof, shall be settled
exclusively by arbitration in accordance with the Rules of the American
Arbitration Association then in effect. Judgment upon the award rendered by the
arbitrator(s) may be entered in any court of competent jurisdiction. Any
arbitration held pursuant to this section in connection with Executive's
termination of employment shall take place in Houston, Texas at the earliest
possible date. If any proceeding is necessary to enforce or interpret the terms
of this Agreement, or to recover damages for breach thereof, the prevailing
party shall be entitled to reasonable attorneys' fees and necessary costs and
disbursements, not to exceed in the aggregate one percent (1%) of the net worth
of the other party, in addition to any other relief to which he or it may be
entitled.

         11. Notice. For purposes of this Agreement, notices and all other
communications provided for in this Agreement shall be in writing and shall be
deemed to have been duly given when delivered by messenger or in person, or when
mailed by United States registered mail, return receipt requested, postage
prepaid, as follows:

         If to the Company:         Texas Biotechnology Corporation
                                    7000 Fannin, 20th Floor
                                    Houston, Texas 77030
                                    Attention: President

         If to the Executive:
                                    --------------------------------------------
                                    c/o Texas Biotechnology Corporation
                                    7000 Fannin, 20th Floor
                                    Houston, Texas 77030

or such other address as either party may have furnished to the other in writing
in accordance herewith, except that notices of change of address shall be
effective only upon receipt.

                                       7
<PAGE>
         12.      General Provisions.

                  (a) Executive's rights and obligations under this Agreement
         shall not be transferable by assignment or otherwise, nor shall
         Executive's rights be subject to encumbrance or subject to the claims
         of the Company's creditors. Nothing in this Agreement shall prevent the
         consolidation of the Company with, or its merger into, any other
         corporation, or the sale by the Company of all or substantially all of
         its properties or assets; and this Agreement shall inure to the benefit
         of, be binding upon and be enforceable by, any successor surviving or
         resulting corporation, or other entity to which such assets shall be
         transferred. This Agreement shall not be terminated by the voluntary or
         involuntary dissolution of the Company.

                  (b) This Agreement and any Employment Agreement with Executive
         plus terms of any stock option plans or grants constitutes the entire
         agreement between the parties hereto in respect to the rights and
         obligations of the parties following a Change in Control. This
         Agreement supersedes and replaces all prior oral and written
         agreements, understandings, commitments, and practices between the
         parties (whether or not fully performed by Executive prior to the date
         hereof), which shall be of no further force or effect.

                  (c) The provisions of this Agreement shall be regarded as
         divisible, and if any of said provisions or any part thereof are
         declared invalid or unenforceable by a court of competent jurisdiction,
         the validity and enforceability of the remainder of such provisions or
         parts thereof and the applicability thereof shall not be affected
         thereby.

                  (d) This Agreement may not be amended or modified except by a
         written instrument executed by the Company and Executive.

                  (e) This Agreement and the rights and obligations hereunder
         shall be governed by and construed in accordance with the laws of the
         State of Texas.

         IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first above written.

                                                TEXAS BIOTECHNOLOGY CORPORATION,
                                                A Delaware Corporation

                                                By:
                                                   -----------------------------

                                                --------------------------------
                                                            Executive

                                       8

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