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                                 EXHIBIT 10.21

                         AMENDMENT TO GENERAL CONTRACTS

      THIS AMENDMENT TO GENERAL CONTRACTS ("Amendment") is entered into January
22, 2000, by and among PEOPLE TO PEOPLE INTERNATIONAL ("PTPI"), a Missouri not
for profit corporation qualified as a 501(c)(3) organization, AMBASSADORS
INTERNATIONAL, INC. ("Ambassadors"), a Delaware corporation, and AMBASSADORS
PROGRAMS, INC. ("AP"), a Delaware corporation and a wholly-owned subsidiary of
Ambassadors.

      WHEREAS, PTPI and AP (by assignment) are parties to a certain General
Contract dated April 1, 1995 which, among other things, governs the conduct by
AP of high school, junior high (middle) school student travel and
college/university exchange programs sanctioned by PTPI ("Student Travel
Contract");

      WHEREAS, PTPI and AP (by assignment) are parties to a certain General
Contract dated April 1, 1995 and a General Contract dated July 1, 1995 which,
among other things, govern the conduct by AP of adult travel and exchange
programs sanctioned by PTPI ("Adult Travel Contracts");

      WHEREAS, PTPI, Ambassadors and AP are parties to a certain General
Contract dated February 12, 1999 which, among other things, governs the conduct
by AP of student and youth sports related travel and exchange programs
sanctioned by PTPI ("Student Sports Contract");

      WHEREAS, PTPI, Ambassadors and AP are parties to a certain General
Contract dated February 12, 1999 which, among other things, governs the conduct
by AP of adult sports related travel and exchange programs sanctioned by PTPI
("Adult Sports Contract"); and

      WHEREAS, the parties hereto wish to extend the terms of the Student
Travel Contract, the Adult Travel Contracts, the Student Sports Contract and
the Adult Sports Contract (hereinafter referred to collectively as "Contracts"
and individually as "Contract").

      NOW, THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, the parties hereto agree as
follows:

      1.    Notwithstanding anything to the contrary contained therein, the
terms of each of the Contracts shall be extended so that their termination
dates shall be June 30, 2010.

      2.    AP shall have the option to extend the term of any or all of the
Contracts through June 30, 2020. In order to exercise the option, it must be
done on or before December 31, 2009.

      3.    Except as specifically set forth in this Amendment, all of the
terms and conditions of the Contracts shall remain in full force and effect.
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     IN WITNESS WHEREOF, the parties hereto have executed this Amendment the day
and year first above written.

                                   AMBASSADORS INTERNATIONAL, INC.

                                   By:  /s/  JOHN UEBERROTH
                                      ---------------------------------------
                                   Its: CEO

                                   AMBASSADORS PROGRAMS, INC.

                                   By:  /s/  JEFFREY D. THOMAS
                                      ---------------------------------------
                                   Its: President

                                   PEOPLE TO PEOPLE INTERNATIONAL

                                   By:  /s/  WILLIAM D. JARVIS
                                      ---------------------------------------
                                   Its: President

     Both parties agree that they will establish new classes of membership for
the various Ambassador Programs and provide a homestay gift package. These
items will be offered as a negative option on Ambassador Program invoices.

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                                                                 EXHIBIT 10.2(f)

                   INTERNATIONAL REMOTE IMAGING SYSTEMS, INC.
                          Employee Stock Purchase Plan

                  (As amended and restated on October 31, 1999)

        1. Participants. All employees and directors of International Remote
Imaging Systems, Inc. (the "COMPANY") may participate in the Employee Stock
Purchase Plan (the "PLAN").

        2. Method of Purchase. To purchase shares under the Plan, a participant
must complete, sign and deliver a Direct Purchase Authorization form for each
transaction, along with payment in full in cash for the dollar amount to be
purchased, to the Controller of the Company. The participant must specify a date
of purchase in the form, and the form and payment must be delivered to the
Controller at least 3 business days prior to the desired date of purchase.
Without prior approval from the Compensation Committee of the Board of
Directors, no person may invest more than 15% of his or her annual cash
compensation from the Company. Annual cash compensation consists of (i) an
employee's base salary plus cash bonuses and commissions or (ii) a director's
annual retainer plus any additional cash director fees for service beyond
normal, routine board services. With respect to any particular date, the
calculation of the 15% investment limit will be based on the individual's then
annual base salary rate or annual retainer rate for that calendar year, plus any
bonuses, commissions and additional director fees actually paid through the date
of calculation in that calendar year. Accrued vacation and Company contributions
to any retirement plan will not be included in the calculation.

        3. Price per Share. Participants may purchase common stock at a price
per share equal to 50% of the greater of (i) the average closing price of the
common stock on the American Stock Exchange for the 10 consecutive trading days
ending on date of purchase or (ii) the closing price of the common stock on the
American Stock Exchange on the date of purchase. The minimum transaction size is
$1,000. Fractional shares will not be issued, and any funds remaining after
purchasing an even number of shares will be refunded.

        4. Restriction on Transfer; Option to Repurchase. The shares purchased
under this Plan must be held and may not be transferred for two (2) years
following the date of purchase except following the death of the participant or
a Change in Control of the Company (as defined below). During the two-year
holding period, the Company will have the option to repurchase the shares if the
participant resigns or is terminated. If the participant resigns or is
terminated for cause, the purchase price will be the amount originally paid by
the participant for the shares to be repurchased. If the participant is
terminated without cause, the purchase price will be the average closing price
of the common stock on the American Stock Exchange for the 10 consecutive
trading days ending on the date of termination or resignation (but not less than
the amount originally paid by the participant). Certificates shall bear a legend
relating to the restriction on transfer and the Company's repurchase option.

        5. Administration; Termination; Amendment. Any questions relating to the
administration of this Plan will be determined in good faith by the Compensation
Committee. This Plan may be terminated or amended at any time by the Board of
Directors or its Compensation Committee without prior notice to the
participants.

        6. Tax Effect; Withholding Obligations. This Plan is not qualified under
Section 401(a)

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(Qualified Pension, Profit-Sharing, and Stock Bonus Plans) or Section 423
(Employee Stock Purchase Plans) of the Internal Revenue Code of 1986.
Accordingly, under current federal tax law, participants must pay taxes on the
discounted purchase of common stock under the Plan for the tax year in which the
2-year restriction period described in paragraph 4 lapses. Upon the lapse of
this restriction, the Company will (i) request an immediate lump sum payment to
satisfy its legally mandated withholding obligation or (ii) deduct the amount
due from the participant's payroll checks or other cash compensation. The
Company may hold any shares of common stock purchased under this Plan until the
participant has satisfied the withholding obligation.

        7. Change in Control. A "Change in Control" means any of the following
events: (i) the dissolution or liquidation of the Company, (ii) a sale of
substantially all the assets of the Company, (iii) a reorganization, merger or
consolidation of the Company with one or more corporations as a result of which
the outstanding common stock of the Company is converted to cash, securities of
another corporation or other property (unless the principal purpose of such
transaction is to change the State of incorporation of the Company or the
shareholders of the Company receive in excess of 60% of the voting stock of such
other corporation) or (iv) the acquisition of the beneficial ownership of more
than 35% of the outstanding common stock of the Company by any person or group
(as defined under the Securities Exchange Act of 1934, as amended).

                                  CERTIFICATION

        The undersigned certifies that (i) he is the duly elected, qualified and
acting Vice President, Finance and Administration, Chief Financial Officer and
Secretary of International Remote Imaging Systems, Inc., a Delaware corporation,
and (ii) the foregoing is a true and correct copy of the Employee Stock Purchase
Plan as amended and restated by the Board of Directors at a meeting held on
October 31, 1999.

Dated:  January ___, 2000            ___________________________________________
                                     Martin S. McDermut
                                     Vice President, Finance and Administration,
                                     Chief  Financial  Officer and Secretary

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                                                                 EXHIBIT 10.3(c)

                                 AMENDMENT NO. 1

                                       TO

                            PATENT LICENSE AGREEMENT

        THIS AMENDMENT TO PATENT LICENSE AGREEMENT (this "Amendment") is dated
as of February 20, 2000 ("Effective Date") and is by and between International
Remote Imaging Systems, Inc., a Delaware corporation ("IRIS"), and Sysmex
Corporation, a Japanese corporation ("SYSMEX") formerly named TOA Medical
Electronics Co., Ltd., ("TOA"), with respect to the following facts:

        A. IRIS and TOA entered into that certain Patent License Agreement dated
as of April 1, 1997 (the "Patent License Agreement"), pursuant to which IRIS
licensed to TOA certain IRIS' patents for use by TOA in the development,
manufacturing, marketing, distribution and sale, on a commercial basis, of
instruments for non-medical, industrial applications in Japan and for certain
Japanese customers outside of Japan.

        B. IRIS now desires to license to SYSMEX, and SYSMEX now desires to
license from IRIS, such patents for use worldwide, subject to the terms and
conditions of the Patent License Agreement, as amended by this Amendment No. 1.

        NOW, THEREFORE, in consideration of the mutual covenants, promises,
agreements set forth in this Amendment, and for other good valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties amend the Patent License Agreement as follows. Unless otherwise stated,
all capitalized terms shall have the same meanings assigned to them in the
Patent License Agreement.

        1. Section 2 of the Patent License Agreement shall be renumbered as
Section 2(a).

        2. The following shall be added as Section 2(b) of the Patent License
Agreement:

               "In consideration of the payments by TOA to IRIS pursuant to
Sections 5.1, IRIS hereby grants to TOA for the Term a non-exclusive right and
license under the IRIS Patents to practice inventions covered by the IRIS
Patents to make Sales of Industrial Products worldwide, other than Sales as to
which a license is granted pursuant to Section 2(a) herein. Sales of Industrial
Products may be made directly by TOA or indirectly through a distributor or
agent of TOA. IRIS represents and warrants that it owns or holds rights to the
IRIS Patents necessary to grant the rights conveyed hereunder, and that the
exercise of such rights by TOA as contemplated hereunder will not conflict with,
infringe or otherwise violate the rights of third parties. This representation
is not intended to cover compliance with United States export laws affecting the
transfer of IRIS Patents, compliance with which TOA assumes responsibility."

        3. Section 5.1(b) of Patent License Agreement shall be amended to read
as follows:

               "b. Periodic Payment.

                      (i) With respect to the license granted under Section
2(a), not later than thirty (30) days following the end of each calendar quarter
throughout the Term, TOA shall pay to IRIS in immediately available funds in US
Dollars royalties in the amount of five percent (5%) of Revenues received by TOA
or its subsidiaries from sales of Industrial Products and Associated Consumable
and Spare Parts during such completed calendar quarter (the "Periodic
Payments"), net of payments made pursuant to Sections 5.1(c)(i).

                      (ii) With respect to the license granted under Section
2(b), not later than thirty (30) days following the end of such calendar quarter
throughout the Term, TOA shall pay to IRIS in

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immediately available funds in US Dollars royalties in the amount of five
percent (5%) of Revenues received by TOA or its subsidiaries from Sales of
Industrial Products and Associated Consumable and Spare Parts during such
completed calendar quarter (the "Periodic Payments"), net of payments made
pursuant to Sections 5.1(c)(ii).

        4. Section 5.1(c) of the Patent License Agreement shall be amended to
read as follows:

               "c. Minimum Payments.

                      (i) With respect to the license granted under Section
2(a), for each of the three (3) 12-month periods commencing July 1, 1998, July
1, 1999 and July 1, 2000 only, TOA shall make minimum payments to IRIS in the
amount of Fifty Thousand US Dollars (US$50,000). Each such minimum payment shall
be payable at the commencement of each such twelve-month (12-month) period and
shall be credited against the payment of Periodic Payments due in respect to
Revenues received by TOA with respect to the license granted under Section 2(a)
during such 12-month period."

                      (ii) With respect to the license granted under Section
2(b), for each of the four (4) 12-month periods commencing July 1, 2000, July 1,
2001, July 1, 2002 and July 1, 2003 only, TOA shall make minimum payments to
IRIS in the amount of Fifth Thousand US Dollars (US$50,000). Each such minimum
payment shall be payable at the commencement of each such twelve-month
(12-month) period and shall be credited against the payment of Periodic Payments
due in respect to Revenues received by TOA with respect to the license granted
under Section 2(b) during such 12-month period."

        5. Within ten (10) business days after execution of this Amendment,
SYSMEX shall pay to IRIS, as an additional payment under Section 5.1(a) of the
Patent License Agreement, with respect to grant of the license pursuant to
Section 2(b) of the Patent License Agreement, the amount of Three Hundred
Thousand US Dollars (US$300,000).

        6. All other terms and conditions of the Patent License Agreement shall
remain in full force and effect.

        7. This Amendment may be executed in any number of counterparts, each of
which shall be deemed an original and all of which shall constitute one and the
same instrument.

INTERNATIONAL REMOTE                        SYSMEX CORPORATION,
SYSTEMS, INC.,                              a Japanese corporation
a Delaware Corporation

By:  /s/  John C. O'Malley                  By:  /s/  Kenichi Yukimoto
Name:     John C. O'Malley                  Name:     Kenichi Yukimoto
Title:    Chairman, CEO, & President        Title:    Senior Managing Director

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