Document:

Fourth Amendment dated July 9, 2010 to Lease Agreement

  
 EXHIBIT 10.2

 FOURTH AMENDMENT TO LEASE 
 THIS FOURTH AMENDMENT TO LEASE (this “Fourth Amendment”) is made as of July 9, 2010, by and between ARE-SAN FRANCISCO NO. 12, LLC, a Delaware limited liability company
(“Landlord”), and EXELIXIS, INC., a Delaware corporation (“Tenant”). 
 RECITALS

 A.    Landlord and Tenant entered into that certain Lease Agreement dated as of
September 14, 2007, as amended by that certain First Amendment to Lease dated May 31, 2008, as further amended by that certain Second Amendment to Lease dated October 23, 2008, and as further amended by that certain Third Amendment to
Lease dated as of October 24, 2008 (as amended, the “Lease”). Pursuant to the Lease, Tenant leases certain premises (“Premises”) in a building located at 249 East Grand Avenue, South San Francisco, California.
The Premises are more particularly described in the Lease. Capitalized terms used herein without definition shall have the meanings defined for such terms in the Lease. 
 B.    Tenant is subleasing all of the third and fourth floors of the Premises (“Subleased Premises”) to Onyx Pharmaceuticals, Inc., a Delaware corporation
(“Subtenant”), pursuant to the certain Sublease dated July 9, 2010, 2010 (“Sublease”). 

C.    Landlord and Tenant desire, subject to the terms and conditions set forth below, to amend the Lease to,
among other things, (i) delete any right of Tenant to maintain any signage at the Project, and (ii) delete Tenant’s right to extend the Base Term of the Lease.  

NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by this reference, the mutual promises
and conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 

 

	1.	Signage.  Notwithstanding anything to the contrary contained in the Lease, (i) commencing on the date of this Fourth Amendment, Tenant
shall have no further right to maintain any signage at the Project including, without limitation, Tenant’s Signs, and (ii) within 15 days after the mutual execution and delivery of this Fourth Amendment by the parties, Tenant shall, at
Tenant’s sole cost and expense, remove all of the Tenant’s Signs from the Project and repair all damage resulting from such removal. 

  

	2.	Adjustments to Rent.  Commencing on the date that Subtenant commences paying full Base Rent (as defined in the Sublease) for the Subleased
Premises and so long as Tenant is not in monetary Default under the Lease, Landlord agrees to reduce the monthly payments owed by Tenant to Landlord pursuant to Section 4(b)(i) of the Lease to $5,454.71 per month and pursuant to
Section 4(b)(iii) of the Lease to $14,349.71 per month. 

  

	3.	Operating Expenses.  Commencing on the Start Date (as defined in the Sublease) for the Subleased Premises and continuing during the Sublease
Term (as defined in the Sublease) so long as Tenant is not monetary Default under the Lease, Landlord shall not include in Operating Expenses under the Lease any expense item that Landlord is not permitted to include in Operating Expenses under the
direct lease between Landlord and Subtenant for the remainder of the Building (excluding the 3,008 square foot server room on the first floor of the Building) (the “Remainder Lease”). Nothing contained herein is intended to excuse
Tenant from paying full Operating Expenses the under the Lease for the 3,008 square foot server room on the first floor of the Building. 

  
 1 

  

 

 

  

	4.	Right to Extend.  Section 40 of the Lease is hereby deleted and of no further force or effect and Tenant has no further right to
extend the Base Term of the Lease. 

  

	5.	Surrender.  Tenant shall have no obligation to restore (i) any Alterations currently existing in the Premises as of the date hereof,
(ii) the server room access alterations which are being undertaken by Tenant in connection with the Sublease, and (iii) any Alterations which Subtenant makes in the Subleased Premises with Landlord’s consent and subject to any
conditions which Landlord is entitled to impose on the Subtenant in connection with such Alterations. 

  

	6.	Miscellaneous. 

a.    This Fourth Amendment is the entire agreement between the parties with respect to the subject matter
hereof and supersedes all prior and contemporaneous oral and written agreements and discussions. This Fourth Amendment may be amended only by an agreement in writing, signed by the parties hereto. 

b.    This Fourth Amendment is binding upon and shall inure to the benefit of the parties hereto, their
respective agents, employees, representatives, officers, directors, divisions, subsidiaries, affiliates, assigns, heirs, successors in interest and shareholders. 
 c.    This Fourth Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when taken together shall constitute one
and the same instrument. The signature page of any counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided such signature page is attached to any other counterpart identical thereto except having
additional signature pages executed by other parties to this Fourth Amendment attached thereto. 

d.    Except as amended and/or modified by this Fourth Amendment, the Lease is hereby ratified and confirmed
and all other terms of the Lease shall remain in full force and effect, unaltered and unchanged by this Fourth Amendment. In the event of any conflict between the provisions of this Fourth Amendment and the provisions of the Lease, the provisions of
this Fourth Amendment shall prevail. Whether or not specifically amended by this Fourth Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of this Fourth
Amendment. 
 [Signatures are on the next page.] 

  
 2 

  

 

 

  
 IN WITNESS
WHEREOF, the parties hereto have executed this Fourth Amendment as of the day and year first above written. 
  

											
	LANDLORD:	 		 	ARE-SAN FRANCISCO NO. 12, LLC,
		 		 	a Delaware limited liability company.
				
		 		 	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P.,
a Delaware limited partnership, managing member
					
		 		 		 	By:	 	ARE-QRS CORP.,
		 		 		 		 	a Maryland Corporation,
general partner
						
		 		 		 		 	By:	 	/s/ Eric S. Johnson
		 		 		 		 	Its:	 	Vice President Real Estate Legal Affairs

  

					
	TENANT:	 	 EXELIXIS, INC.,
 a Delaware corporation

			
		 	By:	 	/s/ Lupe M. Rivera
		 	Its:	 	Executive Vice President, Operations

  
 3Consent to Sublease dated July 9, 2010

  
 EXHIBIT 10.3

 CONSENT TO SUBLEASE 
 This Consent to Sublease (this “Consent”) is made as of July 9, 2010, by and among ARE-SAN FRANCISCO NO. 12, LLC, a Delaware limited liability company
(“Landlord”), EXELIXIS, INC., a Delaware corporation (“Tenant”), and ONYX PHARMACEUTICALS, INC., a Delaware corporation (“Sublessee”), with reference to the following Recitals.

 R E C I T A L S 
 A.    Landlord and Tenant are parties to that certain Lease Agreement dated as of September 14, 2007, as amended by that certain First Amendment to Lease dated May 31,
2008, as further amended by that certain Second Amendment to Lease dated October 23, 2008, as further amended by that certain Third Amendment to Lease dated as of October 24, 2008, and as further amended by that certain Fourth Amendment to
Lease dated as of July 9, 2010 (as amended, the “Lease”), pursuant to which Tenant leases certain premises (the “Premises”) located at 249 East Grand Avenue, South San Francisco, California, and more
particularly described in the Lease. 
 B.    Tenant desires to sublease to Sublessee the third and
fourth floors of the Premises (“Subleased Premises”) pursuant to the provisions of that certain Sublease dated July 9, 2010 (the “Sublease”), a copy of which is attached hereto as Exhibit A. 

C.    Tenant desires to obtain Landlord’s consent to the Sublease and has requested that Landlord grant
certain rights to Sublessee as more particularly described herein. 
 NOW, THEREFORE, in consideration of the foregoing
and the agreements contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord hereby consents to the sublease of the Subleased Premises to Sublessee, such consent being
subject to and upon the following terms and conditions to which Tenant and Sublessee hereby agree: 
  

	1.	All initially capitalized terms not otherwise defined in this Consent shall have the meanings set forth in the Lease unless the context clearly indicates otherwise.

  

	2.	This Consent shall not be effective unless and until Landlord shall have received: (a) a fully executed counterpart of this Consent and of the Sublease, and
(b) an insurance certificate from Sublessee, as insured, evidencing no less than the insurance requirements set forth in the Lease. Tenant and Sublessee each represent and warrant to Landlord that the copy of the Sublease attached hereto as
Exhibit A is true, correct and complete. 

  

	3.	Landlord neither approves nor disapproves the terms, conditions and agreements contained in the Sublease, all of which shall be subordinate and at all times subject to:
(a) all of the covenants, agreements, terms, provisions and conditions contained in the Lease, (b) superior ground leases, mortgages, deeds of trust, or any other hypothecation or security now existing or hereafter placed upon the real
property of which the Subleased Premises are a part and to any and all advances secured thereby and to all renewals, modifications, consolidations, replacements and extensions thereof, and (c) all matters of record affecting the Subleased
Premises and all Legal Requirements. 

  
 1 

  

 

 

  

	4.	Except as expressly provided for in this Consent, nothing contained herein or in the Sublease shall be construed to: 

 

	 	(a)	modify, waive, impair, or affect any of the terms, covenants or conditions contained in the Lease (including, without limitation, Tenant’s obligation to obtain any
required consents for any other or future sublettings), or to waive any breach thereof, or any rights or remedies of Landlord under the Lease against any person, firm, association or corporation liable for the performance thereof, or to enlarge or
increase Landlord’s obligations or liabilities under the Lease (including, without limitation, any liability to Sublessee for any portion of the security deposit held by Tenant under the Sublease), and all terms, covenants and conditions of the
Lease are hereby declared by each of Landlord and Tenant to be in full force and effect. 

  

	 	(b)	require Landlord to accept any payments from Sublessee on behalf of Tenant, except as expressly provided in Section 8 hereof. 

Tenant shall remain liable and responsible for the due keeping, performance and observance of all the terms, covenants and conditions set
forth in the Lease on the part of the Tenant to be kept, performed and observed and for the payment of the Base Rent, Additional Rent and all other sums now and hereafter becoming payable thereunder for all of the Premises, including, without
limitation, the Subleased Premises. 
  

	5.	Notwithstanding anything in the Sublease to the contrary: 

  

	 	(a)	Sublessee does hereby expressly agree to be bound by and to perform and comply with, for the benefit of Landlord, each and every obligation of Tenant under the Lease to
the extent applicable to the Subleased Premises and to the extent incorporated into the Sublease. Landlord and Sublessee each hereby release the other, and waive their respective rights of recovery against the other for direct or consequential loss
or damage arising out of or incident to the perils covered by property insurance carried by such party to the extent of such insurance and waive any right of subrogation which might otherwise exist in or accrue to any person on account thereof.

  

	 	(b)	Tenant and Sublessee agree to each of the terms and conditions of this Consent, and upon any conflict between the terms of the Sublease and this Consent, as between
Landlord and each of Tenant and Sublessee, the terms of this Consent shall control. 

  

	 	(c)	The Sublease shall be deemed and agreed to be a sublease only and not an assignment and there shall be no further subletting or assignment of all or any portion of the
Premises demised under the Lease (including the Subleased Premises demised by the Sublease) except in accordance with the terms and conditions of the Lease or as provided in this Consent. 

 

	 	(d)	 If Landlord terminates the Lease as a result of a default by Tenant thereunder or the Lease terminates for any other reason, the Sublease shall
automatically terminate concurrently therewith. In no event shall Landlord be liable to 

  
 2 

  

 

 

	 	 
Sublessee for any defaults under the Sublease or the Lease by Tenant and/or for any acts or omissions of any kind by Tenant. 

 

	 	(e)	Tenant and Sublessee acknowledge and agree that if Tenant or Landlord elects to terminate the Lease pursuant to the terms thereof, or if Landlord and Tenant voluntarily
elect to terminate the Lease, Landlord shall have no responsibility, liability or obligation to Sublessee except as provided in the Remainder Lease, and the Sublease shall terminate. 

 

	 	(f)	Tenant agrees to reimburse all of Landlord’s costs and expenses in connection with this Consent. 

 

	6.	Any act or omission of Sublessee or anyone claiming under or through Sublessee that violates any of the provisions of the Lease shall be deemed a violation of the Lease
by Tenant. 

  

	7.	Landlord acknowledges and agrees that during the term of the Sublease of the Subleased Premises: 

a.    Affiliate Assignment.  Provided that Sublessee has Sublessor’s consent to do so if
required under the Sublease, Landlord shall not withhold Landlord’s consent to an assignment by Sublessee of Sublessee’s interest in the Sublease to any entity controlling, controlled by or under common control with Subtenant (a
“Sublessee Affiliate”), provided, however, that (i) Landlord shall have the right to approve the form of any such assignment which approval shall not be unreasonably withheld or delayed, (ii) Sublessee shall not be
released from any of its obligations under this Consent), and (iii) Sublessee and the Sublessee Affiliate shall be jointly and severally liable for all Sublessee’s obligations under the Sublease and this Consent. 

b.    Corporate Assignment.  Provided that Sublessee has Sublessor’s consent to do so if
required under the Sublease, Sublessee shall have the right to assign Sublessee’s interest in the Sublease, provided that Sublessee delivers written notice thereof to Landlord within 5 business days thereafter but without obtaining
Landlord’s prior written consent, to a corporation or other entity which is a successor-in-interest to Sublessee, by way of merger, consolidation or corporate reorganization, or by the purchase of all or substantially all of the assets or the
ownership interests of Sublessee provided that (i) such merger or consolidation, or such acquisition or assumption, as the case may be, is for a good business purpose and not principally for the purpose of transferring the Lease, and
(ii) the net worth (as determined in accordance with generally accepted accounting principles (“GAAP”)) of the assignee is not less than the greater of the net worth (as determined in accordance with GAAP) of Sublessee as of
the date of Sublessee’s most current quarterly or annual financial statements, and (iii) such assignee shall agree in writing to assume all of the terms, covenants and conditions of the Sublease and this Consent arising after the effective
date of the assignment. 
 c.    Hazardous Materials.  Provided that Sublessee has
obtained any consents required from Sublessor under the Sublease, the provisions of the Remainder Lease with respect Hazardous Materials including, without limitation, Sections 28 and 30 of the Remainder Lease shall apply with respect
to the Subleased Premises during the term of the Sublease as though they were the Premises (as defined in the Remainder Lease) 

  
 3 

  

 

 

 
and Sublessee agrees to comply for the benefit of Landlord with all such provisions with respect to the Subleased Premises with Landlord entitled to enforce all such provisions against Sublessee.
Tenant shall have no liability to Landlord in connection with Sublessee’s use of Hazardous Materials in the Subleased Premises. 
 d.    Alterations.  Provided that that Sublessee has obtained any consents required from Sublessor under the Sublease, the provisions of the Remainder Lease
with respect to Alterations including, without limitation, Section 12 of the Remainder Lease shall apply with respect to Alterations in the Subleased Premises as though they were the Premises (as defined in the Remainder Lease) and
Sublessee agrees to comply for the benefit of Landlord with all such provisions with respect to the Subleased Premises with Landlord entitled to enforce all such provisions against Sublessee. Tenant shall have no responsibility to Landlord for any
restoration obligations relating to Sublessee’s Alterations. 
 e.    Permitted
Use.  Sublessee shall be permitted to use the Subleased Premises for research and development and as a wet lab, which wet lab use shall be subject to (a) Sublessee’s covenant in Section 3(c) of the Sublease
not to locate a wet lab above or adjacent to the Server Room (as defined in the Sublease), (b) all applicable Legal Requirements, and (c) the requirements of Sections 28 and 30 of the Remainder Lease. 

f.    Assignment & Subletting.  So long as the Sublease remains in effect,
(1) Landlord shall use the reasonableness standard provided for in the first paragraph of Section 22(b) of the Remainder Lease in considering whether to withhold its consent to an assignment or sublease of the Subleased Premises but
in no event shall Sublessee be released from any of its obligations under this Consent and/or the Sublease, and (2) Landlord shall not exercise it “recapture right” under Section 22(b) of the Lease with respect to any
further assignment or sublease of the Subleased Premises. 

g.    Insurance.  Notwithstanding anything to the contrary contained in the Lease, in no event
shall (i) Tenant be required by Landlord to maintain property insurance covering any of Sublessee’s property in the Subleased Premises, and (ii) Sublessee be required by Landlord to maintain property insurance covering any of
Tenant’s property in the Subleased Premises. 
  

	8.	Upon a default by Tenant under the Lease, Landlord may proceed directly against Tenant, any guarantors or anyone else liable under the Lease or the Sublease without
first exhausting Landlord’s remedies against any other person or entity liable thereon to Landlord. If Landlord gives Sublessee notice that Tenant is in default under the Lease, Sublessee shall thereafter make directly to Landlord all payments
otherwise due Tenant, which payments will be received by Landlord without any liability to Landlord except to credit such payments against amounts due under the Lease. Nothing contained herein shall obligate Landlord in any way to terminate the
Lease or take any other action if Tenant is in default under the Lease. The mention in this Consent of any particular remedy shall not preclude Landlord from any other remedy in law or in equity. 

 

	9.	 Tenant shall pay any broker commissions or fees that may be payable as a result of the Sublease and Tenant hereby indemnifies and agrees to hold
Landlord harmless from and against any loss or liability arising therefrom or from any other commissions or fees payable in connection with the Sublease which result from the actions of Tenant.

  
 4 

  

 

 

	 	 
Subject to Section 35 of the Remainder Lease, Sublessee hereby indemnifies and agrees to hold Landlord harmless from and against any loss or liability arising from any commissions or fees
payable in connection with the Sublease which result from the actions of Sublessee. 

  

	10.	Tenant and Sublessee agree that the Sublease will not be modified or amended in any way without the prior written consent of Landlord, which consent shall not be
unreasonably withheld or delayed. Tenant and Sublessee hereby agree that it shall be reasonable for Landlord to withhold its consent to any modification or amendment of the Sublease which would change the permitted use of the Subleased Premises or
which would affect Landlord’s status as a real estate investment trust. Any modification or amendment of the Sublease without Landlord’s prior written consent shall be void and of no force or effect. 

 

	11.	This Consent may not be changed orally, but only by an agreement in writing signed by Landlord and the party against whom enforcement of any change is sought.

  

	12.	This Consent may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when taken together shall constitute but one and
the same instrument. 

  

	13.	This Consent and the legal relations between the parties hereto shall be governed by and construed and enforced in accordance with the internal laws of the State of
California, without regard to its principles of conflicts of law. 

 (Signatures are on the next page.) 

  
 5 

  

 

 

  
 IN WITNESS
WHEREOF, Landlord, Tenant and Sublessee have caused their duly authorized representatives to execute this Consent as of the date first above written. 
  

											
	LANDLORD:	 		 	ARE-SAN FRANCISCO NO. 12, LLC,
		 		 	a Delaware limited liability company
				
		 		 	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P.,
a Delaware limited partnership, managing member
					
		 		 		 	 By:
	 	ARE-QRS CORP., 
a Maryland corporation, general partner
						
		 		 		 		 	By:	 	/s/ Eric S. Johnson
		 		 		 		 	Its:	 	Vice President Real Estate Legal Affairs
			
	TENANT:	 		 	EXELIXIS, INC.,
		 		 	a Delaware corporation
				
		 		 	By:	 	/s/ Lupe M. Rivera
		 		 	Its:	 	Executive Vice President, Operations
			
	SUBLESSEE:	 		 	ONYX PHARMACEUTICALS, INC.,
		 		 	a Delaware corporation
				
		 		 	By:	 	/s/ N. Anthony Coles
		 		 	Its:	 	CEO
				
		 		 	By:	 	/s/ Matthew K. Fust
		 		 	Its:	 	CFO

  

  

 

 

  
 EXHIBIT A

 COPY OF SUBLEASE 
 [Attached] 
 See Exhibit 10.4 to Form 10-Q filed 11/4/2010

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00180-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00180-of-00352.parquet"}]]