Document:

Assignment, Assumption and Consent

 Exhibit 10.23 
 ASSIGNMENT, ASSUMPTION AND CONSENT 
 1. Assignment of Lease 
 FOR A VALUABLE CONSIDERATION, the receipt and adequacy of which are hereby acknowledged, the undersigned COPPER MOUNTAIN NETWORKS, INC., a California
corporation (“Assignor”) hereby assigns and transfers to NEUROTHERMIA, INC., a California corporation (“Assignee”), all of Assignor’s right, title and interest in and under that certain lease (the “Lease”) with a
Lease Reference Date of August 12, 1997 by and between Assignor and R. G. HARRIS CO. and ELIZABETH G. HARRIS, HENRY K. WORKMAN and DON C. SHERWOOD, TRUSTEES OF THE HARRIS FAMILY REVOCABLE TRUST (“Landlord”), covering those certain premises
(the “Premises”) located at 3931 Sorrento Valley Blvd., San Diego, California, as more particularly described in the Lease and that certain Sublease with VidiMedix Corporation dated December 1, 1997. 
 This assignment is made in connection with an agreement by and between Assignor and Assignee and in connection therewith, the undersigned: 
 (a) Agrees that the effectiveness of this assignment and the Assumption of Lease provided for herein are subject to the consent of Landlord; which consent
is predicated upon satisfaction of the conditions set forth in Section 3 hereof. 
 (b) Assignor shall be released from Assignor’s
liability for any of the obligations of the tenant under the Lease arising or occurring after the Effective Date. 
 (c) Assignor warrants
that as of the Effective Date specified below there will be no uncured default on the part of Assignor pursuant to the Lease and agrees to indemnify and defend Assignee against any claims arising out of such a claimed default. 
 (d) Assignor shall deliver possession of the Premises to Assignee on or before August 2, 1999 (the “Date of Delivery”) but Assignor shall
continue to pay all rent and the other sums due Landlord under the Lease until the Effective Date, as defined hereinbelow, except that Assignee shall pay utilities, janitorial and shall maintain insurance for the Premises from the Date of Delivery.
In the event that the Date of Delivery occurs after August 2, 1999, Assignor shall reimburse Assignee for all rent and the other sums due Landlord subsequent to October 1, 1999, equal to the number of days that the Date of Delivery is
delayed. 
  

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 (e) Assignor agrees that if Assignee spends at least $30,000.00 on tenant improvement construction,
(including construction necessary to bring the existing bathrooms in that portion of the Premises not currently subleased into ADA compliance) then Assignor shall contribute $20,000.00 towards Assignee’s tenant improvement costs. If Assignee
spends at least $40,000.00 on tenant improvement construction, (including construction necessary to bring the existing bathrooms in that portion of the Premises not currently subleased into ADA compliance) then Assignor shall contribute $30,000.00
toward Assignee’s tenant improvement costs (“Assignor’s Contribution”). Assignor shall deliver fifty percent (50%) of Assignor’s Contribution upon submission to Assignor by Assignee of an accepted bid for the tenant
improvement construction. Assignor shall deliver the remaining portion of Assignor’s Contribution upon completion of the work and submission to Assignor by Assignee of copies of paid invoices showing the total amount expended for the tenant
improvement construction. In no event shall Assignor’s Contribution exceed $30,000.00. Assignee shall be responsible for all other tenant improvement costs and Landlord shall have no responsibility therefor except as otherwise specifically
provided in the Lease. Assignor hereby releases to Assignee any and all of Assignor’s claims to any prepayment or deposit held by any person or entity relating to the Premises or any leasehold improvements (including, without limitation, any
utility deposits, performance and/or completion bonds, and the like). All such sums shall be held by such person or entity for the benefit of Assignee, subject to the provisions of the applicable agreement requiring such prepayment or deposit.
Additionally, Assignor shall convey to Assignee prior to the Date of Delivery the full amount of the Security Deposit held by Assignor pursuant to the Sublease, in the amount of $21,845.00, which shall be held by Assignee in accordance with the
terms and conditions of Section 5 of the Sublease. 
 (f) Assignor represents that to the best of its knowledge, the Premises and all
building systems are in good working order and in good cosmetic condition. As of the date hereof and the Date of Delivery, Assignor represents and warrants that to the best of its knowledge: (a) Assignor is lawfully possessed of the
lessee’s interest in and to the Lease and all of the improvements and alterations made by or for Assignor to the Premises, including, but not limited to, those certain furnishings, trade fixtures and equipment that will remain in the Premises
after the Date of Delivery pursuant to the terms of the Lease, if any (the “Personal Property”), and the sublessor’s interest in and to that certain sublease with Vidimedix Corp. (the “Sublease”), which is in full force and
effect and, to the best of Assignor’s knowledge, pursuant to which, the subtenant thereunder has no claim to any offset, defense or abatement of any amounts payable pursuant to such Sublease; (b) Assignor has the right and authority to
assign its interest in the Lease, the 
  

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 Personal Property and the Sublease to Assignee (subject to the terms of the Lease and the Sublease); (c) the copy of
the Lease attached hereto as Exhibit “B” is a true, full and correct copy of the Lease and the same has not been modified except as set forth herein; (d) the copy of the Sublease attached hereto as Exhibit “C” is a true,
full and correct copy of the Sublease and the same has not been modified; (e) the Lease and the Sublease are in full force and effect; (f) Assignor is not in default under the Lease and, to the best of Assignor’s knowledge, Landlord
is not in default thereunder, and Assignor is not aware of any event or existing condition which, with the giving of notice and/or the passage of time, would constitute such a default; (g) Assignor is not in default under the Sublease and, to
the best of Assignor’s knowledge, Vidimedix Corp. (“Sublessee”) is not in default thereunder, and Assignor is not aware of any event or existing condition which, with the giving of notice and/or the passage of time, would constitute
such a default; (h) Assignor’s interest in the Lease, the leasehold improvements (including without limitation the Personal Property), and the Sublease shall be delivered to Assignee free and clear of all liens, encumbrances and
creditor’s rights held by any party claiming by, through or under Assignor, and (i) the Premises, and all portions thereof that Assignor is obligated to repair and maintain under the Lease, and the Personal Property, are in good operating
condition and repair and, to the best of Assignor’s knowledge, free of any Hazardous Materials. Within two (2) weeks prior to the Date of Delivery, Assignor shall obtain from Sublessee and provide to Assignee an executed Estoppel
Certificate from Sublessee in the form of Exhibit “D” attached hereto. Within forty-five (45) days following the Date of Delivery, Assignor shall, at Assignor’s sole cost and expense, remove all of its signage from the building
in which the Premises are located and from any monuments of the surrounding property and restore any and all damage arising from such removal. If Assignor fails to timely remove its signage and repair such damages, Assignee shall have the right, but
without any obligation, to remove such signage and perform such restoration work, and Assignor shall be obligated to reimburse Assignee for any actual and reasonable amount expended by Assignee in performing such work of removal and restoration
within fifteen (15) days following delivery of written evidence of such payment by Assignee. 
 As between Assignor and Assignee,
Assignor hereby assigns the Lease and Sublease to Assignee, and shall be responsible for the performance of all obligations of the tenant under the Lease and the sublessor under the Sublease that accrued prior to the Date of Delivery (with the
exception of Assignor’s obligations to be performed after the date of Delivery as expressly set forth herein), for all liabilities arising from Assignor’s particular use of the Premises to the extent arising prior to the Date of Delivery
and for all claims, costs, expenses and liabilities 
  

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 relating to Assignor’s material breach of any term, condition, covenant or agreement of the Lease or the Sublease to
be performed by Assignor prior to the Date of Delivery, and Assignor agrees to indemnify and hold harmless Assignee from any claims, losses, costs or expenses (including reasonable counsel fees) suffered or incurred by Assignee arising out of or
resulting from any failure by Assignor to perform any such obligations. To the extent Assignee is billed or otherwise becomes obligated to pay any amount attributable to any period prior to the Date of Delivery relating to the Lease, the Sublease,
the Personal Property or the Premises, Assignor shall reimburse Assignee for such amounts no later than fifteen (15) days after delivery of written evidence that such amounts are attributable to such period of Assignor’s responsibility and
have been paid by Assignee. 
 (g) Acknowledges that Assignor has read the disclaimer set forth in Section 4 and the general provisions
set forth in Section 5 of this instrument and executes this instrument with full knowledge and acceptance of such sections, both of which are incorporated herein, including, but not limited to, Assignor’s consent to the terms and
conditions of Lease Amendment No. 1, which shall amend the Lease with respect to this assignment. 
 (h) Concurrently with the execution
of this Assignment, Assumption and Consent, Assignor shall pay to Landlord the sum of $500.00 toward Landlord’s attorneys’ fees and costs pursuant to Section 7.4(c) of the Lease. 
 (i) Upon execution of this Assignment, Assumption and Consent, Assignor shall pay to Assignee the sum of $21,845.00, which represents the
Subtenant’s Security Deposit currently on deposit with Assignor. 
 (j) Upon the Effective Date, Assignor shall pay to Assignee its pro
rata share of all rent received by Assignor from Subtenant for the month of October 1999. 
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 The effective date (“Effective Date”) of this Assignment, Assumption and Consent shall be
October 2, 1999. 
 EXECUTED this 16th day of July, 1999. 
  

							
	ASSIGNOR:	 		 	COPPER MOUNTAIN NETWORKS, INC.,
		 		 	a California corporation
				
		 		 	By	 	 /s/ [Illegible]

		 		 		 	President
				
		 		 	By	 	 /s/ [Illegible]

		 		 		 	Secretary
			
		 	Address:	 	10145 Pacific Heights Blvd, Suite 100
		 		 	San Diego, Ca 92121

 2. Assumption of Lease 
 Assignee hereby accepts the foregoing assignment and assumes and agrees to be bound by and perform all obligations of the tenant pursuant to the Lease and
this Assignment, Assumption and Consent arising on or after the Effective Date and to abide by all of the terms, provisions, covenants and conditions of the Lease and this Assignment, Assumption and Consent, including but not limited to those
providing for the payment of Base Monthly Rent, Property Operating Expenses, additional rent and other charges. 
 As between Assignor and
Assignee, Assignee hereby assumes the Sublease and shall be responsible for the performance of all obligations of the tenant under the Lease and the sublessor under the Sublease accruing from and after the Effective Date, for all liabilities arising
from Assignee’s use of the Premises to the extent arising from and after the Date of Delivery and for all claims, costs, expenses and liabilities relating to Assignee’s material breach of any term, condition, covenant or agreement of the
Lease or the Sublease to be performed by Assignee from and after the Date of Delivery, and Assignee agrees to indemnify, defend and hold harmless Assignor from any claims, losses, costs or expenses (including reasonable counsel fees) suffered or
incurred by Assignor arising out of or resulting from any failure by Assignee to perform any such obligations. 
 The undersigned
acknowledges and agrees that: 
 (a) Assignee has inspected the Premises and the building of which it forms a part and has received and read a
copy of the Lease and is assuming the obligations of tenant pursuant to the Lease based upon Assignee’s own investigation and not upon any statements or representations of or on behalf of Assignor or Landlord. 
  

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 (b) In connection with the within transaction, no person has had any authority to make any
representations on behalf of Landlord or Assignor except Landlord and Assignor concerning the Premises and/or the building of which it forms a part and such representations, if any, have not been relied upon by the undersigned. 
 (c) The effectiveness of this Assumption and the Assignment of Lease provided for herein are subject to the consent of Landlord, which consent is
predicated upon satisfaction of the conditions set forth in Sections 3 and 5 of this instrument. 
 (d) There may be no further assignment or
transfer of the Lease or subletting of the Premises, or any portion thereof, except upon the written consent of Landlord and/or as otherwise provided in the Lease. 
 (e) Except as provided in Amendment No. 1 to the Lease incorporated herein by Paragraph 5 hereof, there may be no change in the use of the Premises and no remodeling of or alterations to the Premises without, in
each instance, the prior written consent of Landlord and in conformance with the terms of the Lease. 
 (f) Assignee agrees to save,
indemnify, defend and hold Assignor harmless from and on account of any claims, demands, actions, losses, expenses and liabilities (including attorneys’ fees) of Assignor under the Lease or Sublease, arising after the Date of Delivery, and on
account of, or arising out of, the obligations and liabilities of the Assignor so assumed by Assignee hereunder. 
 (g) Upon execution of
this Assignment, Assumption and Consent, Assignee shall pay to Assignor the sum of $20,400.00 which represents Assignor’s Security Deposit currently on deposit with Landlord. 
 (h) Assignee has read the disclaimer set forth in Section 4 and the general provisions set forth in Section 5 of this instrument and executes
this instrument with full knowledge and acceptance of such sections, both of which are incorporated herein. 
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 EXECUTED this 15th day of July, 1999. 
  

					
	ASSIGNEE:	 	NEUROTHERMIA, INC.,
		 	a California corporation
			
		 	By	 	 /s/ John Dobak

		 	Its	 	President
			
		 	By	 	 /s/ [Illegible]

		 	Its	 	Secretary

 3. Consent to Assignment 
 Landlord hereby consents to the foregoing Assignment and Assumption in accordance with the Lease by and between Landlord and Assignor. It is understood
and agreed that: 
 (a) The foregoing consent is not a waiver of Landlord’s right to consent to or impose restrictions upon any future
assignment or subletting. 
 The undersigned Landlord does hereby certify that (1) the copy of the Lease attached hereto as Exhibit
“B” is a true, full and correct copy of the Lease and the Lease has not been modified or amended in any way; (2) the Lease is in full force and effect, and, to the best of Landlord’s knowledge, (i) neither party is in
default thereunder, and (ii) nor do any circumstances exist which, upon notice and/or expiration of any applicable grace period, would constitute a default thereunder; (3) the payment of rent and all other amounts payable by Assignor under
the Lease is current through the month of June, 1999;. and (5) the Landlord shall not require any of the leasehold improvements made in and to the Premises (excluding Personal Property which may be removed without permanent damage to the
Premises), made by or on behalf of the Assignor or Sublessee as of the date hereof to be altered or removed by the holder of the lessee’s interest in and to the Lease upon the expiration or earlier termination of the Lease. Further, the
undersigned Landlord does hereby represent and warrant that the Landlord holds record title to the premises demised under the Lease and that the Lease is subject to no underlying ground lease. 
 (b) Landlord releases Assignor from any liability for any of the obligations of the tenant under the Lease arising or occuring after the Effective Date.

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 (c) Landlord holds no security or other deposit for or on behalf of Assignor except the sum of $20,400.00
and such security or other deposit shall be retained by Landlord and returned to Assignee in accordance with Section 3.6 of the Lease. Landlord shall have no liability to Assignor subsequent to the Effective Date relative to any such security
deposit. Landlord hereby acknowledges Assignor’s release to Assignee of any and all of Assignor’s claims to any prepayment or deposit held by Landlord relating to the Premises or leasehold improvements (including, without limitation, any
utility deposits, performance and/or completion bonds, and the like). All prepayments and deposits held by Landlord pursuant, to the Lease shall be held by Landlord for the benefit of Assignee, subject to the provisions of the Lease requiring such
prepayment or deposit. 
 (d) The foregoing consent does not include a consent to the transfer of any renewal, extension or expansion rights,
or any other special privileges or rights granted to tenant pursuant to the Lease, if any, and all such rights and privileges shall terminate upon the Effective Date. 
 (e) On October 1, 1999, Landlord shall pay a leasing commission of $9,720.00 to The Irving Hughes Group, Inc. and on January 1, 2000, Landlord shall pay an additional leasing commission of $9,720.00 to The Irving
Hughes Group, Inc. 
 This consent shall become effective only upon the execution of a copy of this instrument by each party hereto and
delivery of such fully executed copy to Landlord. 
 EXECUTED as of this 15th day of July, 1999. 
  

			
	LANDLORD:
	
	 R. G. Harris Co.,
 a California
corporation

		
	By:	 	 /s/ [Illegible]

	Title:	 	President
	
	 /s/ Elizabeth G. Harris

	 Elizabeth G. Harris, Trustee of the
 Harris
Family Revocable Trust

	
	 /s/ Henry K. Workman

	 Henry K. Workman, Trustee of the
 Harris
Family Revocable Trust

	
	 /s/ Don C. Sherwood

	 Don C. Sherwood, Trustee of the
 Harris
Family Revocable Trust

  

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 4. Disclaimer 
 THE ASSIGNOR AND ASSIGNEE NAMED IN SECTIONS 1 AND 2 OF THIS INSTRUMENT EACH ACKNOWLEDGE THAT THE LEASE MAY PROVIDE FOR THE PAYMENT OF ADDITIONAL RENT PERIODICALLY ON AN ESTIMATED BASIS (INCLUDING PROPERTY OPERATING
EXPENSES) WITH ADJUSTMENT TO ACTUAL AMOUNTS DUE AS SPECIFIED IN THE LEASE. NOTWITHSTANDING ANY ESTIMATE OR ALLOCATION OF SUCH AMOUNTS PROVIDED BY LANDLORD TO ASSIGNOR AND ASSIGNEE TO FACILITATE THE TRANSFER PROVIDED FOR HEREIN, ASSIGNOR AND ASSIGNEE
UNDERSTAND AND ACKNOWLEDGE THAT (1) ANY SUCH ESTIMATE OR ALLOCATION IS ONLY AN ESTIMATE BY LANDLORD AND IS NOT INTENDED AS AND SHALL NOT BE CONSTRUED AS A LIMITATION OR CEILING UPON THE ACTUAL AMOUNTS WHICH MAY BE DUE, (2) AS RESPECTS
LANDLORD, ASSIGNEE SHALL BE SOLELY RESPONSIBLE FOR ANY ADDITIONAL AMOUNTS OF ADDITIONAL RENT DUE TO LANDLORD BY VIRTUE OF SUCH ADJUSTMENTS AND SHALL BE SOLELY ENTITLED TO ANY REFUNDS OR CREDITS RESULTING FROM SUCH ADJUSTMENTS AND (3) ANY
PRORATION OF ANY SUCH AMOUNTS BETWEEN ASSIGNOR AND ASSIGNEE SHALL BE STRICTLY BETWEEN THEM, AND LANDLORD NEED NOT BE CONCERNED THEREWITH. 
 5. General Provisions 
 (a) If any party hereto commences any action against any other party hereto arising out of or in
connection with this instrument, or the Lease, the prevailing party or parties shall be entitled to recover from the losing party or parties reasonable attorneys’ fees as determined by the court as well as costs of suit. 
 (b) Any notice, demand, request, consent, approval or communication that any party hereto desires or is required to give to any other party or parties
hereto shall be in writing and either served personally or sent by prepaid, first class mail properly addressed and deposited in the State of California to the address appearing below the signatures of each party hereto. Notice shall be deemed
communicated three business days after the time of mailing if mailed as provided in this paragraph. 
 (c) Except as otherwise provided
herein, Assignor and Assignee agree that Landlord has no liability for any fees or commissions to any real estate broker or agent in connection with the assignment and assumption of the Lease. All such fees and commissions shall be the
responsibility of Assignor and Assignee. 
 (d) This instrument shall be binding upon and inure to the benefit of the parties hereto and
their respective successors in interest. 
 (e) In the event of any conflict between the terms of this instrument and the terms of the Lease,
the terms of the Lease shall control. 
  

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 (f) This Assignment, Assumption and Consent is conditioned upon Assignee’s and Landlord’s
subsequent execution of Lease Amendment No. 1, a copy of which is attached hereto as Exhibit “A”. In the event that Landlord and Assignee fail to execute Lease Amendment No. 1 on or before July 30, 1999, and unless Landlord
and Assignee agree otherwise in writing, this Assignment, Assumption and Consent shall become null and void and none of the parties hereto shall have any continuing obligation hereunder. 
 (g) Prior to the Date of Delivery, the Assignee’s address for all notices and other communications under the Lease shall be: 
 NEUROTHERMIA, INC. 
 6199 Cornerstone Court East, Suite 106 
 San Diego, CA 92121 
 Attn: Vice President Operations 
 and
following the Date of Delivery, the Assignee’s address for all notices and other communications under the Lease shall be: 
 NEUROTHERMIA, INC. 
 3931 Sorrento Valley Boulevard 
 San Diego, CA 92121 
 Attn: Vice President Operations 
 with a copy in each case to: 
 Brobeck, Phleger & Harrison, LLP 
 550 West C Street, Suite 1300 
 San Diego, CA 92101 
 Attn: W. Scott Biel, Esq. 
 (h) As an inducement to enter into this Assignment and the attached Amendment, each of Assignor, Assignee and Landlord represents and warrants to the other that, except for David Marino of The Irving Hughes Group, Inc. (the
“Broker”), such party has had no dealings with any real estate broker or other person in respect to this Assignment or the attached Amendment. Each of the parties shall indemnify and hold harmless the others from and against all damages or
claims that may be asserted by any person with whom the indemnifying party has purportedly dealt. As between Assignor and Assignee, Assignor acknowledges and agrees that Assignor shall pay all fees due to the Broker arising out of this Assignment.
Landlord acknowledges and agrees that Assignee shall have no obligation to pay any fees due to the Broker arising out of the attached Amendment unless Assignee has otherwise agreed with the Broker. 
 (i) This instrument shall be construed and interpreted in accordance with the laws of the State of California. 
  

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 (j) This instrument may be executed in one or more counterparts, each of which shall be deemed an
original, but all of which shall constitute one and the same agreement after each party has executed such a counterpart. 
  

									
	ASSIGNOR:	 		 	LANDLORD:
			
	 COPPER MOUNTAIN NETWORKS, INC.,
 a California
corporation
	 		 	 R. G. Harris Co.,
 a California
corporation

					
	By:	 	 /s/ [Illegible]
	 		 	By:	 	 /s/ [Illegible]

	Title:	 	 President
	 		 	Title:	 	President
				
	By:	 	 /s/ [Illegible]
	 		 	 /s/ Elizabeth G. Harris

	Title:	 	 Secretary
	 		 	 Elizabeth G. Harris, Trustee of the
 Harris
Family Revocable Trust

			
	 ASSIGNEE:
	 		 	 /s/ Henry K. Workman
 Henry
K. Workman, Trustee of the
 Harris Family Revocable Trust

			
	 NEUROTHERMIA INC.,
 a California corporation
	 		 	 /s/ Don C. Sherwood
 Don C.
Sherwood, Trustee of the
 Harris Family Revocable Trust

					
	By:	 	 /s/ John Dobak
	 		 		 	
	Title:	 	President	 		 		 	
					
	By:	 	 /s/ [Illegible]
	 		 		 	
	Title:	 	Secretary	 		 		 	

  

 11Lease Amendment No. 2

 Exhibit 10.24 
 LEASE AMENDMENT NO. 2 
 This Lease Amendment No. 2 (hereinafter referred to as the “
Amendment”) is entered into as of October 16, 2002, by and between E.G. SIRRAH, LLC, a California limited liability company (“Landlord”), as successor-in-interest to R.G. HARRIS CO. and ELIZABETH G. HARRIS, HENRY K. WORKMAN and
DON C. SHERWOOD, TRUSTEES OF THE HARRIS FAMILY REVOCABLE TRUST (collectively “Original Landlord”), and INNERCOOL THERAPIES, INC., a California corporation formerly known as NEUROTHERMIA, INC., (“Tenant”), and is made with
reference to the following facts: 
 A. Original Landlord and COPPER MOUNTAIN NETWORKS, Inc., a California corporation (“Original Tenant”)
previously executed a written lease dated August 12, 1997 (the “Original Lease”) of and to those certain premises in San Diego, California, commonly known as and located at 3931 Sorrento Valley Boulevard (the “Premises”).

 B. Effective as of October 2, 1999, Original Tenant assigned all of its right, title and interest in the Original Lease to Tenant, Tenant assumed all
of the duties and obligations of Original Tenant under the Original Lease and Landlord consented to the assignment and released Original Tenant from any liability for any of the tenant’s obligations under the Original Lease occurring after the
effective date of said assignment. The Original Lease was amended by that certain Lease Amendment No. 1 dated as of August 1, 1999 (“First Amendment”) whereby Original Landlord, Original 
  

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 Tenant and Tenant amended the Lease in several respects, including, without limitation (i) extending the term of the
Original Lease, (ii) expanding the use clause of the Original Lease, (iii) revising the rent schedule payable by Assignee under the Original Lease, (iv) accepting the existing improvements as part of the Premises to be surrendered by
Tenant, and (v) revising the letter of credit obligations under the Original Lease. The Original Lease as amended by the First Amendment is hereinafter referred to as the “Lease.” 
 C. Landlord and Tenant now desire to further amend the Lease as set forth in this Amendment, including, without limitation (i) extending the term of the Lease,
(ii) establishing the rent payable during the extended term, (iii) providing Tenant with an improvement allowance to refurbish the Premises, and (iii) revising the letter of credit obligations under the Lease. 
 NOW, THEREFORE, in consideration of the terms, covenants and conditions of the Lease and the Amendment, and other good and valuable consideration, the receipt and
sufficiency of which is hereby acknowledged, the parties hereby agree as follows: 
 1. Defined Terms. All capitalized terms not
defined herein shall have them meanings set forth in the Lease, as amended. 
 2. Term. The term of the Lease is hereby extended for
an additional four (4) year period from October 31, 2003 to October 31, 2007. 
  

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 3. Rent. The “Base Monthly Rent” clause set forth in Section 1.1 of the Lease is
hereby deleted and the following is substituted in its place and stead: The term “Base Monthly Rent” shall mean the following: 
  

				
	 November 1, 2002 – October 31, 2003
	  	$	22,800 NNN
	 November 1, 2003 – October 31, 2004
	  	$	24,000 NNN
	 November 1, 2004 – October 31, 2005
	  	$	24,000 NNN
	 November 1, 2005 – October 31, 2006
	  	$	25,200 NNN
	 November 1, 2006 – October 31, 2007
	  	$	25,200 NNN

 4. Tenant Improvement Allowance. Landlord shall provide to Tenant a tenant improvement
allowance of One Hundred Thousand Dollars ($100,000), which Tenant may use to make improvements to the Premises (the “Refurbishment Allowance”), which shall be subject to Landlord’s approval. Landlord’s approval rights and
obligations with respect to such improvements shall be consistent with the terms and conditions set forth in Section 6.1 of the Lease, and such improvements shall not include trade fixtures or personal property. The construction of any
improvements, alterations or modifications of the Premises by Assignee shall be made in accordance with the provisions of Section 6.1 of the Lease. The terms and conditions of Section 2.5 of the Lease relating to the payment of the Tenant
Improvement Allowance shall be applicable to payment of the Refurbishment Allowance payable hereunder, except that the second to the last sentence of Section 2.5 is hereby deleted. Tenant shall be required to incur the improvement costs and
fees to be reimbursed by Landlord pursuant to the Refurbishment Allowance by October 31, 2005, and to the extent that Tenant has not incurred such improvements costs and fees by such deadline (or has not submitted invoices evidencing the
expenditure of such costs and fees within sixty (60) days following such date), any unused portion of the Refurbishment Allowance shall cease to be available to Tenant for reimbursement and Landlord shall have no liability to Tenant for any
costs or fees of improvements incurred by tenant after such deadline. Contrary to the terms of Section 2.6 of the Lease, Landlord may only require the removal of such improvements by Assignee if Assignee is so notified in writing at the time
the improvements are consented to in writing by Landlord. 
  

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 5. Letter of Credit. Provided Tenant has not been in default of any of its obligations under the
Lease beyond all applicable notice and cure periods set forth therein, the amount of the letter of credit referred to in Section 3.7 of the Lease shall be reduced as of October 31, 2002 to $25,000, and Tenant may provide Landlord with a
replacement letter of credit in such amount as of such date, and such letter of credit shall be eliminated entirely as of October 31, 2003. 
 6. Broker’s Commission. Upon mutual execution of this Second Amendment to Lease, Landlord shall pay a leasing commission to Irving Hughes for the procurement of this Second Amendment to Lease of three percent (3%) for the
value of the Basic Monthly Rent beginning with November 1, 2003 through October 31, 2007. Tenant and Landlord warrant to one another that they have had no dealings with any broker or agent in connection with this Second Amendment other
than Irving Hughes and each of them, respectively, covenants to pay, hold harmless and indemnify the other party from and against any and all costs, expense or liability for any compensation, commissions and charges claimed by any broker or agent
pursuant to any claimed representation of the indemnifying party other than Irving Hughes with respect to this Second Amendment of Lease or the negotiation thereof, or arising from a breach of the foregoing warranty. 
 7. Ratification. The Lease as amended by this Second Amendment embodies the entire agreement between the parties relative to the subject matter
hereof, and there are no other oral or written agreements between the parties; nor any representations made by either party relative to the subject matter hereof, which are not expressly set forth herein. The effectiveness of this Second Amendment
is expressly conditioned upon the ratification hereof by Tenant’s board of directors on or before November 30, 2002, and none of the terms hereof or obligations hereunder shall be effective (including, but not limited to, the reduction in
rent payable by Tenant or of the letter of credit held by Landlord) unless and until this Second Amendment is so ratified by Tenant’s board. If Tenant’s board of directors so ratifies this Second Amendment, 
  

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 (1) it shall be deemed incorporated in the Lease by reference as of the date of this Second Amendment first set forth
above, (2) any rent payment by Tenant prior to such ratification shall be adjusted to reflect such retroactive effect, and (3) the amount of the letter of credit shall be immediately reduced pursuant to Section 5 above. If Tenant
delivers notice to Landlord by November 30, 2002 that Tenant’s board of directors has refused to ratify this Second Amendment, it shall become null and void as of the date of such notice and the Lease shall continue in full force and
effect and unaffected by this Second Amendment. Except as herein specifically amended, the Lease and all of the terms, covenants and provisions thereof are hereby ratified and reaffirmed and shall remain in full force and effect. In the event of any
inconsistencies between this Second Amendment and the Lease, the terms and provisions of this Second Amendment shall govern and take precedence 
 8. Counterparts. This Second Amendment may be executed in any number of counterparts, each of which shall be deemed to be an original and all of which taken together shall comprise but a single instrument. Delivery of an executed
counterpart of a signature page to this Second Amendment by telecopier shall be effective as delivery of a manually executed counterpart of this Second Amendment. 
 IN WITNESS WHEREOF, the parties hereto have executed this Second Amendment effective as of the Effective Date. 
  

							
	LANDLORD:	 	TENANT:
		
	E.G. SIRRAH, LLC,	 	INNERCOOL THERAPIES, INC.,
	a California limited liability company	 	a California Corporation
				
	By:	 	 /s/ Henry K. Workman, Jr
	 	By:	 	 /s/ John Dobak

		 	Henry K. Workman, Jr	 	Title:	 	President
		 	Managing Member	 		 	
				
		 		 	By:	 	 /s/ [Illegible]

		 		 	Title:	 	Secretary

  

 -5-

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