Document:

Amendment #2 to Production Agreement

 Exhibit 10.15 
  
 Execution Copy 
  
 AMENDMENT NO. 2 TO PRODUCTION AGREEMENT 
  
 This Amendment No. 2 to Production Agreement (this “Amendment”) is made and entered into this 28th day of April, 2003 by and between OraSure
Technologies, Inc., a Delaware corporation, with its registered offices at Bethlehem, Pennsylvania 18015 U.S.A. (the “Purchaser”), and Koninklijke Utermöhlen N.V., a limited liability company organized under the laws of the
Netherlands, with its registered offices at Wolvega, the Netherlands (the “Seller”). Seller and Purchaser are each referred to herein as a “Party” and collectively as the “Parties.” 
  
 BACKGROUND 
  
 Seller and Purchaser are parties to a Production Agreement, dated June 8,
1998, as amended by Amendment No. 1 to Production Agreement (“Amendment No. 1”), dated as of December 11, 2001 (collectively, the “Original Agreement”), pursuant to which Seller agreed to produce certain products related to the
Histofreezer Business for the Purchaser. The Parties desire to amend further the Original Agreement in order to provide for the production of a New Product by Seller for Purchaser for ultimate sale into the over-the-counter or consumer market in
certain territories. 
  
 AGREEMENT 
  
 NOW, THEREFORE, in consideration of the foregoing, and of the mutual promises
and covenants contained in this Amendment, Seller and Purchaser, intending to be legally bound, hereby agree as follows: 
  
 1.    Definitions.    Capitalized terms not otherwise defined in this Amendment shall have the meanings set
forth in the Original Agreement. 
  
 2.    New Product.    Exhibit 1 to the Original Agreement is hereby amended to add the following New Product (referred to herein as the “OTC Product”): 
  

			
	 Art. Nr.

	  	Description

	 1001-0063
	  	Compound W Freeze OFF

  
 The OTC Product shall be deemed to be
a “Product” under the Original Agreement. 
  
 3.    OTC Product Specifications.    The Specifications for the OTC Product (the “OTC Product Specifications”) shall mean the technical file set forth in Exhibit 3 to this Amendment
as the same shall be amended from time to time pursuant to Section 3.1 of the Original Agreement, together with current ISO 9002/46002 standards, CE standards, all relevant laws, all relevant regulations, all relevant directives, the Quality System
Regulation (including then current Good Manufacturing Practices) as promulgated by the United States Food and Drug Administration, principles of good workmanship, acknowledged standards and specific (but reasonable) instructions of the Purchaser in
the relevant order for any OTC Product(s). The OTC Product Specifications shall be deemed to be the “Specifications” for the OTC Product for all purposes of the Original Agreement. 
  
 4.    Other
Specifications.    The Specifications for all other Products are hereby amended to include the Quality System Regulation (including then current Good Manufacturing Practices) as promulgated by the United States Food and Drug
Administration. 
  
 5.    Supply of
Packaging Components.    Purchaser shall be responsible for supplying or arranging for the supply of the packaging and labeling materials noted in Exhibit 4 to this Amendment (collectively, the “OTC Packaging
Components”). Seller shall not be responsible for providing or paying for the OTC Packaging Components, but shall use such OTC Packaging Components in packaging and assembling the OTC Product purchased hereunder. 

 6.    Purchase Price. 
  
 (a) The price for the purchase of OTC Product shall be as set forth in
Exhibit 6 to this Amendment. 
  
 (b) The parties acknowledge a
typographical error in Section 4.2 of Amendment No. 1. The change from “30%” to “10%” in such Section should have been, and is hereby deemed to have been, made to Section 4.3 of the Original Agreement. 
  
 7.    No Other
Changes.    Except as set forth in this Amendment, the Original Agreement remains in full force and effect without any other changes. The Original Agreement, together with this Amendment, constitute the entire agreement
between the Seller and the Purchaser with respect to the subject matter hereof and thereof and supersede and cancel all previous negotiations, agreements, and commitments, whether oral or in writing, with respect to such subject matter. All
references to the Original Agreement shall be deemed to mean the Original Agreement as amended by this Amendment. 
  
 8.    Counterparts.    This Amendment may be executed in two or more counterparts, each of which shall be
deemed to be an original, but all of which together shall constitute one and the same instrument. A facsimile transmission of a signed original shall be deemed to be the same as delivery of a signed original. 
  
 9.    Governing Law.    This
Amendment and any controversy, claim or dispute arising under this Amendment shall be governed by, and construed in accordance with, the laws of the Netherlands. 
  
 IN WITNESS WHEREOF, the undersigned duly authorized officers of the Seller and the Purchaser have executed this Amendment as
of the date first above written. 
  

									
	 ORASURE TECHNOLOGIES, INC.
	 	 	 	 KONINKLIJKE UTERMÖHLEN N.V.

					
	By:	 	/s/ Mike Gausling	 	 	 	By:	 	/s/ D. T. van der Vat
	 	 	
	 	 	 	 	 	

	 	 	 Name: Mike Gausling
 Title:   President
and CEO
	 	 	 	 	 	 Name: D.T. van der Vat
 Title:   President

  

 EXHIBIT 3 
  

OTC Product Specifications 
  
 * * * * * * * * * * * * 

 EXHIBIT 4 
  

OTC Package Components 
  

	1.	Boxes for each unit of OTC Product, with labeling approved by Purchaser; 

	2.	Package inserts or instructions in form approved by Purchaser; 

	3.	Shipping cases (standard corrugated); 

	4.	Shipping case label in form approved by Purchaser; and 

	5.	Transparent tamper resistant labels for the box (if required). 

 EXHIBIT 6 
  

OTC Product Price 
 (Per
Unit) 
  

					
	 	  	 	  	Price

	1.	  	 Materials
	  	 
	 	  	     - 110 ml. canister filled with 80 ml. of refrigerant
	  	* * * *
	 	  	     - Foam Bud Applicators (12 in a bag)
	  	* * * *
	2.	  	 Labor
	  	* * * *
	3.	  	 Overhead
	  	* * * *
	4.	  	 Profit
	  	* * * *
	 	  	 	  	

	 	  	         Total Price Per Unit
	  	* * * *

  
 A unit
of OTC Product shall consist of an 110 ml canister filled with 80 ml. of refrigerant and a 12-count set of 5 mm. foam tip applicators, manufactured, assembled and packaged in accordance with the OTC Product Specifications.First Amendment to Loan and Security Agreement

 Exhibit 10.24 
  
 FIRST AMENDMENT TO 
  
 LOAN AND SECURITY AGREEMENT 
  
 This FIRST AMENDMENT TO LOAN AND SECURITY AGREEMENT (“First Amendment”) is made and entered into this 23rd day of May, 2003, by and
between ORASURE TECHNOLOGIES, INC., a Delaware corporation (“Borrower”), and COMERICA BANK—CALIFORNIA, a California banking corporation (“Bank”). 
  
 WHEREAS, Borrower and Bank are parties to a Loan and Security Agreement dated as of September 10, 2002 (as amended,
restated and otherwise modified from time to time, the “Agreement”); and 
  
 WHEREAS, Bank and Borrower wish to amend the Agreement as set forth herein; 
  
 NOW THEREFORE, the parties hereto, intending to be legally bound hereby, agree as follows: 
  
 1.    The definition of “Non-Revolving Advance
Date” in Exhibit A to the Agreement is hereby amended to read in its entirety as follows: 
  
 “Non-Revolving Advance Date” means each of three (3) Business Days following the Closing Date, December 10, 2002, March 10, 2003 and June 10,
2003, or any other date occurring after the Closing Date and prior to September 10, 2003 by which Borrower has accumulated invoices for at least $100,000 of CAPEX Equipment eligible for reimbursement under Section 2.1(d) hereof. 
  
 2.    Except as expressly modified by this First
Amendment, the Agreement remains in full force and effect as originally written. 
  
 3.    This First Amendment may be executed in multiple counterparts, each of which shall be deemed an original and all of which shall constitute one and the same agreement. 
  
 IN WITNESS WHEREOF, the undersigned have executed this
First Amendment as of the day and year first above written. 
  

			
	 ORASURE TECHNOLOGIES, INC.

		
	 By:
	 	 /s/ Ronald H. Spair

	 	 	   Ronald H. Spair
   Chief Financial Officer

  

			
	 COMERICA BANK- CALIFORNIA

		
	 By:
	 	 /s/ Michael T. Wilk

	 	 	   Michael T. Wilk
   First Vice PresidentJoinder Agreement - Suntrust Bank

 Exhibit 10.1.2 
  
 JOINDER AGREEMENT 
  
 This JOINDER AGREEMENT (this “Agreement”) dated as of March 14, 2003, is executed by SUNTRUST BANK (the “New
Lender”) for the benefit of BANK OF AMERICA, N.A., as Administrative Agent for itself and the other Lenders parties to that certain Credit Agreement dated as of February 1, 2002, among SUNOCO LOGISTICS PARTNERS OPERATIONS L.P., as
borrower, the Guarantors named therein, the financial institutions from time to time party thereto (collectively, the “Lenders”), and Bank of America, N.A., as Administrative Agent (as renewed, extended, amended or restated,
the “Credit Agreement”; capitalized terms not otherwise defined herein being used herein as defined in the Credit Agreement). 
  
 The New Lender has agreed to become a Lender and is required to execute this Agreement pursuant to Section 2.13 of the Credit Agreement.

  
 NOW THEREFORE, in consideration of the premises and other good
and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the New Lender hereby agrees as follows: 
  
 1. The New Lender (a) confirms that it has received a copy of the Credit Agreement, the Guaranties and such other documents and information as it has
deemed appropriate to make its own credit analysis and decision to enter into this Amendment and become a Lender party to the Credit Agreement, (b) agrees that it will, independently and without reliance upon the Administrative Agent or any Lender
and based on such documents and information as it shall deem appropriate at the time, continue to make its own credit decisions in taking or not taking action under the Loan Documents, (c) appoints or authorizes the Administrative Agent to take such
action on its behalf and to exercise such powers under the Loan Documents as are delegated by the terms thereof, together with such powers as are reasonably incidental thereto, (d) agrees that it will perform in accordance with their terms all of
the obligations which by the terms of the Loan Documents are required to be performed by it as a Lender, and (e) specifies as its lending office and address for notices the offices set forth on the Administrative Details Form provided to the
Administrative Agent. 
  
 2. The New Lender shall be a Lender with
all rights, powers, and privileges attendant thereto and shall have a Committed Sum of $25,000,000. 
  
 3. This Agreement shall be governed by and construed and enforced in accordance with the laws of the State of New York. 
  
 4. This Agreement may be signed in any number of counterparts, each of which
shall be an original, but all counterparts shall together constitute one and the same instrument. 
  
 5. THIS AGREEMENT REPRESENTS THE FINAL AGREEMENT
BETWEEN THE PARTIES ABOUT THE SUBJECT MATTER OF THIS AMENDMENT AND
MAY NOT BE CONTRADICTED BY EVIDENCE OF ERIOR, CONTEMPORANEOUS, OR SUBSEQUENT
ORAL AGREEMENTS OF THE PARTIES. THERE ARE NO UNWRITTEN ORAL AGREEMENTS
BETWEEN THE PARTIES. 
  
 Remainder of Page Intentionally Blank; 
 Signature Page to Follow. 
  

 IN WITNESS WHEREOF, the New Lender has executed this Joinder Agreement as of the day and year first
written above. 
  

					
	 New Lender:
  
 SUNTRUST BANK

		
	By:	 	/s/    DAVID J. EDGE        
	 	 	

	 	 	 Name:
	 	David J. Edge
	 	 	 Title:
	 	Director

  
 Signature Page
to 
 Joinder Agreement 
  

 Acknowledged and Agreed:  
  

					
	 Administrative Agent: 
  
 BANK OF AMERICA, N.A.

		
	By:	 	/s/    RONALD E. MCKAIG        
	 	 	

	 	 	 Name:
	 	Ronald E. McKaig
	 	 	 Title:
	 	Managing Director

  
 Signature Page to

 Joinder Agreement 
  

							
	 Borrower:
  
 SUNOCO LOGISTICS PARTNERS OPERATIONS L.P.

		
	By:	 	SUNOCO LOGISTICS PARTNERS GP LLC,
its General Partner
			
	 	 	By:	 	/s/    PAUL A. MULHOLLAND        
	 	 	 	 	

	 	 	 	 	 Name:
	 	Paul A. Mulholland
	 	 	 	 	 Title:
	 	Treasurer

  
 Signature Page to

 Joinder Agreement 
  

 Consent Granted: 
  
 Each of the undersigned Guarantors ratifies and affirms its Guaranty and consents to the addition of the New Lender and the increase in the Aggregate Committed Sum to
$225,000,000. 
  
 Guarantors: 
  

							
	 SUNOCO LOGISTICS PARTNERS L.P.,
 a
Delaware limited partnership, as a Guarantor

		
	By:	 	 SUNOCO PARTNERS LLC,
 a Delaware limited liability company,
 its General Partner

			
	 	 	By:	 	/s/    PAUL A. MULHOLLAND        
	 	 	 	 	

	 	 	 	 	 Name:
	 	Paul A. Mulholland
	 	 	 	 	 Title:
	 	Treasurer

  

					
	SUNOCO LOGISTICS PARTNERS OPERATIONS GP LLC, a Delaware limited liability company, as a Guarantor
		
	By:	 	/s/    PAUL A. MULHOLLAND        
	 	 	

	 	 	 Name:
	 	Paul A. Mulholland
	 	 	 Title:
	 	Treasurer

  

							
	SUNOCO PARTNERS MARKETING & TERMINALS L.P., a Texas limited partnership, as a Guarantor
		
	By:	 	SUNOCO LOGISTICS PARTNERS OPERATIONS GP LLC, a Delaware limited liability company, its General Partner
			
	 	 	By:	 	/s/    PAUL A. MULHOLLAND        
	 	 	 	 	

	 	 	 	 	 Name:
	 	Paul A. Mulholland
	 	 	 	 	 Title:
	 	Treasurer

  

							
	SUNOCO PIPELINE L.P., a Texas limited partnership, as a Guarantor
		
	By:	 	SUNOCO LOGISTICS PARTNERS OPERATIONS GP LLC, a Delaware limited liability company, its General Partner
			
	 	 	By:	 	/s/    PAUL A. MULHOLLAND        
	 	 	 	 	

	 	 	 	 	 Name:
	 	Paul A. Mulholland
	 	 	 	 	 Title:
	 	Treasurer

  
 Signature Page to

 Joinder Agreement

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