Document:

EX-10.27

 Exhibit 10.27 

CORREGIDOR THERAPEUTICS, INC. 

Amended and Restated Stock Restriction Agreement 

WHEREAS, [—] (the “Stockholder”) is the holder of [—] shares (the “Shares”) of common stock, par value $0.001 per share (the “Common Stock”) of Corregidor Therapeutics, Inc., a Delaware corporation (the
“Company”), after giving effect to a stock-split effected by the Amended and Restated Certificate of Incorporation filed December 22, 2010; 

WHEREAS, the Stockholder and the Company previously entered into a Stock Restriction Agreement in connection with the initiation of the
Stockholder’s Business Relationship (as defined below) with the Company (the “Original Agreement”); and 
 WHEREAS, in
connection with the continuation of the Stockholder’s Business Relationship with the Company, the Stockholder and the Company hereby agree to amend and restate the Original Agreement to provide for the imposition of contractual restrictions
with respect to the Shares, including the right of the Company to repurchase the Shares in certain circumstances, in accordance herewith. 

NOW, THEREFORE, the Stockholder and the Company agree that the Original Agreement is superseded in its entirety, and amended and restated, as
follows. The terms and conditions attached hereto are also a part hereof. 
  

					
	Name of Stockholder:	  	[—]	  	
	Date:	  	December 27, 2010	  	
	Number of Shares that are Vested Shares on the Vesting Start Date:	  	[—]	  	
	Number of Shares that are Unvested Shares on the Vesting Start Date:	  	[—]	  	
	Vesting Start Date:	  	December 27, 2010	  	

 Vesting Schedule 
  

					
	Shares Vesting on one (1) year anniversary of Vesting Start Date (the “Cliff Vest Date”):	  	[—]	  	
	The remaining Unvested Shares shall vest in [—] equal monthly installments commencing on the last day of the calendar month immediately following the Cliff Vest Date and continuing
in like fashion thereafter until all Unvested Shares become Vested Shares. (For clarity, [—] Shares shall vest in the final monthly installment to account for a rounding calculation.)	  	[—]	  	
	
	The Shares are subject to vesting provisions and repurchase rights as set forth herein.

																	
	STOCKHOLDER	 		 	CORREGIDOR THERAPEUTICS, INC.
					
	By:	 	  
	 		 	By:	 	  

		 	Name:	 	[—]	 		 		 	Name:	 	[—]
		 		 	Address:	 	  
	 		 		 		 	Title:	 	[—]
		 		 		 	  
	 		 		 		 		 	

 [SIGNATURE PAGE TO [—] AMENDED AND RESTATED STOCK
RESTRICTION AGREEMENT] 

 CORREGIDOR THERAPEUTICS, INC. 

Stock Restriction Agreement — Incorporated Terms and Conditions 

The Company and the Stockholder agree to the following terms and conditions: 

1. Vesting if Business Relationship Continues. 

(a) Vesting Schedule. Unvested Shares shall become Vested Shares (or shall “vest”) on such dates in an amount equal to
the number of shares set forth opposite the applicable date on the cover page hereto. Shares that have been so earned by performance and continuity of the Stockholder’s Business Relationship with the Company shall be regarded as “Vested
Shares” and Shares that have not been so vested by performance and continuity of the Stockholder’s Business Relationship with the Company (including, without limitation, pursuant to the acceleration of vesting provisions hereof) shall
be regarded as “Unvested Shares.” Unvested Shares and Vested Shares shall be subject to the transfer restrictions and repurchase provisions described in Section 2. The Stockholder agrees not to Transfer, except to the Company
or any successor to the Company, any Unvested Shares or any interest therein. All Shares shall be held in escrow by the Company in accordance with the terms of Section 3 below. If the Stockholder’s Business Relationship with the Company
ceases, voluntarily or involuntarily, with or without cause, no Unvested Shares shall become Vested Shares thereafter under any circumstances with respect to the Stockholder, unless otherwise stated herein (including, without limitation, pursuant to
the acceleration of vesting provisions hereof). Any determination under this Agreement as to the status of a Business Relationship or other matters referred to above shall be made in good faith by the Board of Directors of the Company (the
“Board”). A majority of the Board, in its sole and absolute discretion, may accelerate any vesting dates. 
 (b)
Accelerated Vesting Upon Termination by the Company Without Cause or by the Stockholder for Good Reason. If, after the Vesting Start Date, the Stockholder’s Business Relationship is terminated by the Company without Cause or by the
Stockholder for Good Reason, then all of the then Unvested Shares that would have become Vested Shares had the Stockholder’s Business Relationship continued for one (1) year following such termination shall become Vested Shares as of the
date of such termination. 
 (c) Accelerated Vesting Upon Death or Permanent Disability. If, after the Vesting Start Date, the
Stockholder’s Business Relationship is terminated as a result of the Stockholder’s death or Permanent Disability, then all of the then Unvested Shares that would have become Vested Shares had the Stockholder’s Business Relationship
continued for one (1) year following such termination shall become Vested Shares as of the date of such termination. 
 (d)
Accelerated Vesting Upon Acquisition. If, after the Vesting Start Date and prior to the termination of the Stockholder’s Business Relationship, or if, after the Vesting Start Date and within two (2) months after the termination of
the Stockholder’s Business Relationship if such termination was by the Company without Cause or by the Stockholder for Good Reason, an Acquisition occurs, then all of the then Unvested Shares shall become Vested Shares as of the first to occur
of: (i) the first date three hundred sixty (360) days following the closing of such Acquisition or, if the Unvested Shares are not assumed by the entity effecting the Acquisition, 

  
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immediately prior to the closing of such Acquisition; or (ii) the date of termination of the Stockholder’s Business Relationship by the Company without Cause or by the Stockholder for
Good Reason; in any case provided that the Stockholder’s Business Relationship is not first terminated by the Company for Cause. 
 (e)
Definitions. The following definitions shall apply: 
 “Acquisition” means (i) any acquisition
of the Company by a Person (as defined below) not an Affiliate (as defined below) of the Company, by means of merger or other form of corporate reorganization in which the outstanding ownership interests of the Company are exchanged for securities
or other consideration issued, or caused to be issued, by the acquiring Person and in which the holders of the Company’s ownership interests hold less than fifty percent (50%) of the acquiring or surviving Person (other than a mere
reincorporation transaction), or (ii) a sale of all or substantially all of the assets of the Company by a Person not an Affiliate of the Company; provided, however, that a “Change of Control” shall not include an initial
public offering of the Company’s stock or a mere recapitalization transaction or the sale of equity by the Company through a private offering of shares to venture capital, institutional, strategic or other equity security financing for the
account of the Company; (B) “Affiliate” means with respect to a specified Person, any Person that directly or indirectly controls, is controlled by, or is under common control with, the specified Person (as used in this
definition, the term “control” means the possession, directly or indirectly, of the power to direct or cause the direction of the management and policies of a person or entity, whether through ownership of voting securities, by
contract or otherwise); and (C) “Person” means any individual, company, corporation, association, partnership (general or limited), joint venture, trust, estate, limited liability company or other legal entity or organization.

 “Business Relationship” means service to the Company, its successor or any affiliate of the Company as an
employee, officer or director of, or a consultant or advisor to, the Company or its successors. 
 “Cause”
shall have the meaning given such term, or term of similar effect, in Stockholder’s employment or consulting agreement with the Company or, in the absence of such term, or term of similar effect, in Stockholder’s employment or consulting
agreement with the Company, “Cause” shall mean Stockholder’s (i) conviction of, or guilty plea to, a felony, (ii) commission of a fraudulent, illegal or materially dishonest act in connection with the
Stockholder’s Business Relationship, as reasonably determined by the Board of Directors of the Company (“Board”) acting in good faith, or (iii) willful and repeated failure or refusal to attempt to perform his duties to the
Company or material breach of any agreement between the Company and the Stockholder, provided that the Stockholder shall have thirty (30) days to cure in all material respects such Cause event(s) following the Stockholder’s receipt of
written notice by the Company, which notice shall specifically identify the Cause upon which the termination is based and after the Stockholder has been given such notice and the opportunity to appear before the full Board of Directors to discuss
such alleged Cause (unless such act or omission, by its nature, may not be remedied, in which case such determination of Cause may be effective immediately). 

  
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 “Good Reason” shall have the meaning given such term, or term of
similar effect, in Stockholder’s employment agreement with the Company or, in the absence of such term, or term of similar effect, in Stockholder’s employment agreement with the Company, “Good Reason” shall mean, if and only if
the Stockholder is then employed by the Company, (i) any reduction in the Stockholder’s salary (other than in connection with a reduction in salary with respect to all other senior executives of the Company), (ii) any material
diminution or other adverse change in the Stockholder’s authority, responsibilities, or duties without the prior written consent of the Stockholder, (iii) a material breach by the Company of any material agreement between the Company and
the Stockholder, or (iv) the relocation, without the written consent of the Stockholder, of the place of business at which the Stockholder principally performs Stockholder’s duties for the Company to a location that is greater than 35
miles from the location Stockholder principally performs Stockholder’s duties for the Company immediately prior to such relocation. Notwithstanding the foregoing, (A) the Stockholder will be deemed to have given consent to the condition(s)
described in this definition if the Stockholder does not provide written notice to the Company of such Good Reason event(s) within ninety (90) days from first occurrence of such Good Reason event(s) and (B) to the extent the Company has
not cured such Good Reason event(s) during the 30-day cure period, the Stockholder must terminate the Stockholder’s employment for Good Reason no later than one hundred and eighty (180) days following the occurrence of such Good Reason
event(s) by providing the Company thirty (30) days prior written notice of termination, which may run concurrently with the Company’s cure period. 

“Permanent Disability” shall have the meaning given such term, or term of similar effect, in
Stockholder’s employment or consulting agreement with the Company or, in the absence of such term, or term of similar effect, in Stockholder’s employment or consulting agreement with the Company, “Permanent Disability” shall
means that (i) the Stockholder has been incapacitated by mental or physical injury or illness so as to be prevented thereby from engaging in the performance of the Stockholder’s duties to the Company and (ii) such incapacity has
continued for a period of ninety (90) days. 
 “Transfer” means and includes, but is not limited to,
the act of selling, assigning, transferring, pledging, hypothecating, encumbering, mortgaging, giving and any other form of disposing or conveying, whether voluntary or by operation of law or court order, and also includes transfers taking effect by
reason of death or as a distribution by the Stockholder to his or her spouse as such spouse’s joint or community property interest pursuant to a decree of dissolution, operation of law, divorce, property settlement agreement or for any other
reason relating to termination of the Stockholder’s marriage to such spouse. 
 (f) Termination of Business Relationship. For
purposes hereof, the Stockholder’s Business Relationship with the Company shall not be considered as having terminated during any leave of absence if such leave of absence has been approved in writing by the Board and if such written approval
contractually obligates the Company to continue the Stockholder’s Business Relationship with the Company after the approved period of absence; in the event of such an approved leave of absence, vesting of Unvested Shares shall be suspended (and
the period of the leave of absence shall be added to all vesting dates) unless otherwise provided in 

  
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the Company’s written approval of the leave of absence. Except as otherwise stated herein, this Agreement shall not be affected by any change of Business Relationship within or among the
Company so long as the Stockholder continuously remains an employee, officer, director or consultant of the Company in accordance with the definition of “Business Relationship.” 

(g) Conditions of Acceleration. Any acceleration of vesting contemplated by Sections 1(b), 1(c) and/or 1(d): (i) shall be
contingent upon the execution (and non-revocation), within sixty (60) days following termination of the Stockholder’s Business Relationship or closing of an Acquisition, as applicable, by the Stockholder of a general release of the
Company, its affiliates, stockholders, directors, officers, employees and agents from all claims (other than claims for the payments to be made and benefits to be provided), together with an agreement to not make any disparaging comments, statements
or communications about the Company, its affiliates, stockholders, directors, officers, employees or agents, or its management or business practices for three (3) years following termination of the Stockholder’s Business Relationship or
closing of an Acquisition, as applicable, all in a form reasonably provided by the Company; (ii) shall be contingent upon the Executive’s compliance with all continuing obligations under the Company’s Employee Non-Competition,
Non-Solicitation, Confidentiality and Assignment Agreement (the “Proprietary Rights Agreement”); and (iii) together with any remedies provided in any consulting or employment agreement between the Company and the Stockholder
covering the Stockholder’s Business Relationship at the relevant time, shall constitute the sole remedy of the Stockholder in the event of a termination of the Stockholder’s Business Relationship in the circumstances set forth in Sections
1(b), 1(c) and/or 1(d). 
 2. Restrictions on Transfer: Repurchase by the Company. 

(a) Restriction on Transfer of Unvested and Vested Shares. The Stockholder may not Transfer all or any of the Unvested Shares except to
the Company pursuant to this Section 2, and may Transfer Vested Shares only in accordance with the transfer restrictions provided in this Section 2, Section 5 or elsewhere in this Agreement. The Stockholder may not at any time
transfer any Shares to any individual, corporation, partnership or other entity that engages in any business activity that is in competition, directly or indirectly, with the products or services being developed, manufactured or sold by the Company.
The determination of whether any proposed transferee engages in any business activity that is in competition with those of the Company shall be made by the Board in good faith. This prohibition shall be applicable in addition to and separately from
the other provisions hereof. 
 (b) Repurchase of Unvested Shares. Upon the termination of the Stockholder’s Business
Relationship, subject to the application of Section 1(d), the Stockholder, in the case of the Stockholder’s death, the executor of the Stockholder’s estate, and any Permitted Transferee (as hereinafter defined) shall sell to the
Company (or the Company’s assignee) all Unvested Shares in accordance with the procedures set forth below. The purchase price (the “Unvested Share Repurchase Price”) of such Unvested Shares (the “Repurchased Unvested
Shares”) shall be the aggregate par value of such shares (subject to adjustment as herein provided). Such sale shall be effected by the delivery by the Escrow Holder (as defined below) to the Company of a certificate or certificates
evidencing the Repurchased Unvested Shares, each duly endorsed for transfer to the Company. Within 120 days following receipt thereof, the Company shall mail a check for the Unvested Repurchase Price to the Stockholder or shall cancel indebtedness
owed to 

  
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the Company by the Stockholder by written notice mailed to the Stockholder, or both. Upon the mailing of a check in payment of the purchase price in accordance with the terms hereof or
cancellation of indebtedness as aforesaid, the Company shall become the legal and beneficial owner of the Unvested Shares being repurchased and all rights and interests therein or relating thereto (even if the Stockholder or Escrow Holder fails to
deliver such shares), and the Company shall have the right to retain and transfer to its own name or cancel the number of Unvested Shares being repurchased by the Company. 

(c) Permitted Transferee. Notwithstanding the foregoing and the provisions of Section 5, the Stockholder may transfer:
(i) all or any Vested Shares as a gift to any family member or to any trust or similar estate planning entity for the benefit of any such family member or the Stockholder (each a “Permitted Transferee”), provided that any such
Permitted Transferee shall agree in writing with the Company, as a condition precedent to such transfer, to be bound by all of the provisions of this Agreement to the same extent as if such Permitted Transferee were the Stockholder, (ii) any or
all Vested Shares to any Permitted Transferee by will or the laws of descent and distribution, in which event each such Permitted Transferee shall be bound by all of the provisions of this Agreement to the same extent as if such Permitted Transferee
were the Stockholder or (iii) any or all Vested or Unvested Shares to any Permitted Transferee by court order, in which event each such Permitted Transferee shall be bound by all of the provisions of this Agreement to the same extent as if such
Permitted Transferee were the Stockholder. As used herein, the word “family” shall include any spouse, lineal ancestor or descendant (whether natural or adoptive), brother or sister of the Stockholder. 

3. Escrow of Shares. All Shares shall be held in escrow by the Company, as escrow holder (“Escrow Holder”). 

The Escrow Holder is hereby directed to transfer the Unvested Shares in accordance with this Agreement or instructions signed by both the
Stockholder and the Company. If the Company or any assignee exercises its repurchase rights hereunder, the Escrow Holder, upon receipt of written notice of such exercise from the Company or such assignee, shall take all steps necessary to accomplish
such transfer. The Stockholder hereby grants the Escrow Holder an irrevocable power of attorney coupled with an interest to take any and all actions required to effect such transfer. 

The Escrow Holder may act in reliance upon advice of counsel in reference to any matter(s) connected with this Agreement, and shall not be
liable for any mistake of fact or error of judgment, or for any acts or omissions of any kind, unless caused by its willful misconduct or gross negligence. 

With respect to any Unvested Shares that become Vested Shares, the Company may, at its option, issue a new certificate for the number of
shares which have become Vested Shares and shall deliver such certificate to the Stockholder and shall deliver to the Escrow Holder a new certificate for the remaining Unvested Shares in exchange for the certificate then being held by the Escrow
Holder, provided that any Vested Shares so delivered shall remain subject to the applicable provisions of this Agreement. 

  
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 Subject to the terms hereof, the Stockholder shall have all the rights of a stockholder with
respect to the Shares while they are held in escrow. If, from time to time while the Escrow Holder is holding Shares, there is any stock dividend, stock split or other change in or respecting such Shares, including the automatic conversion of the
Shares into voting common stock of the Company, any and all new, substituted or additional securities to which the Stockholder is entitled by reason of the Stockholder’s ownership of the Shares shall be immediately subject to this escrow,
deposited with the Escrow Holder and included thereafter as “Unvested Shares” or “Vested Shares,” as applicable, for purposes of this Agreement and the repurchase rights of the Company. 

4. Certain Tax Matters. If the Company in its discretion determines that it is obligated to withhold any tax in connection with the
transfer of, or the lapse of restrictions on, the Shares, then the Stockholder hereby agrees that the Company may withhold from the Stockholder’s wages or other remuneration the appropriate amount of tax to the extent permitted by law. At the
discretion of the Company but in consultation with the Stockholder, the amount required to be withheld may be withheld in cash from such wages or other remuneration to the extent permitted by law. The Stockholder further agrees that, if the Company
does not withhold an amount from the Stockholder’s wages or other remuneration sufficient to satisfy the withholding obligation of the Company, the Stockholder will make reimbursement on demand, in cash, for the amount underwithheld, provided
that the Company has provided the Stockholder with written detail concerning the basis for and amount of the withholding obligation of the Company. 

The Stockholder represents that he has received tax advice from the Stockholder’s own personal tax advisor on the tax consequences of a
purchase of the Shares. The Stockholder understands the tax consequences of filing (and not filing) a Section 83(b) election under the Internal Revenue Code of 1986, as amended. The filing of a Section 83(b) election is the
Stockholder’s responsibility. 
 5. Restrictions on Transfer of Vested Shares’ Company’s Right of First Refusal. 

(a) Exercise of Right. Vested Shares may not be Transferred without the written consent of the Board, except in accordance with
Section 2 or in accordance with the further provisions of this Section 5. If the Stockholder desires to Transfer all or any part of the Vested Shares to any person other than the Company or a Permitted Transferee (an
“Offeror”), the Stockholder shall: (i) obtain in writing an irrevocable and unconditional bona fide offer (the “Offer”) for the purchase thereof from the Offeror; and (ii) give written notice (the
“Option Notice”) to the Company setting forth the Stockholder’s desire to transfer such shares, which Option Notice shall be accompanied by a photocopy of the Offer and shall set forth at least the name and address of the
Offeror and the price, number of Vested Shares proposed to be sold and terms of the Offer. Upon receipt of the Option Notice, the Company shall have an assignable option to purchase all or any portion of such Vested Shares (the “Offered
Shares”) specified in the Option Notice, such option to be exercisable by giving, within 30 days after receipt of the Option Notice, a written counter-notice to the Stockholder. If the Company elects to purchase such all or any portion of
the Offered Shares, it shall be obligated to purchase, and the Stockholder shall be obligated to sell to the Company or its assignee, such Offered Shares at the price and terms indicated in the Offer within 30 days from the date of delivery by the
Company 

  
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of such counter-notice. To the extent that the consideration proposed to be paid by the Offeror for the shares consists of property other than cash or a promissory note, the consideration
required to be paid by the Company may consist of cash equal to the fair market value of such property. The fair market value shall be determined using the procedure set forth in Section 2(d). 

(b) Sale of Vested Shares to Offeror. The Stockholder may, for 60 days after the expiration of the Option Notice, sell to the Offeror,
pursuant to the terms of the Offer, all of the Offered Shares not purchased or agreed to be purchased by the Company or its assignee; provided, however, that prior to the sale of such Vested Shares to an Offeror, such Offeror shall execute an
agreement with the Company pursuant to which such Offeror agrees to be subject to the restrictions set forth in this Agreement. If any or all of such Vested Shares are not sold pursuant to an Offer within the time permitted above, the unsold Vested
Shares shall remain subject to the terms of this Agreement. In addition, if Stockholder purports to sell any Shares in contravention of the terms of this Section 5 (a “Prohibited Transfer”), then to the extent Stockholder fails
to sell such Shares to the Company as required pursuant to Section 5(a) above, the Company may, at its option, in addition to all other remedies it may have, send to Stockholder the purchase price for such Stock as is herein specified and
transfer to the name of the Company on the Company’s books the certificate or certificates representing the Shares to be sold. 
 (c)
Expiration of Company’s Right of First Refusal and Transfer Restrictions. The first refusal rights of the Company and the transfer restrictions set forth in this Agreement shall expire as to Vested Shares immediately prior to the closing
of a public offering of Common Stock by the Company pursuant to an effective registration statement filed under the Securities Act of 1933, as amended (the “Securities Act”). 

6. Investment Representation. The Stockholder represents, warrants and acknowledges that the Stockholder: (a) has had an
opportunity to ask questions of and receive answers from a Company representative concerning the terms and conditions of this investment; (b) acquired the Shares with the Stockholder’s own funds, for the Stockholder’s own account for
the purpose of investment, and not with a view to any resale or other distribution thereof in violation of the Securities Act; (c) is a sophisticated investor with such knowledge and experience in financial and business matters as to be able to
evaluate the merits and risks of an investment in the Shares; and (d) that the Stockholder is able to and must bear the economic risk of the investment in the Shares for an indefinite period of time because the Shares have not been registered
under the Securities Act, and therefore, cannot be offered or sold unless they are subsequently registered under the Securities Act or an exemption from such registration is available. Furthermore, the Company may place legends on any stock
certificate representing the Shares with the securities laws and contractual restrictions thereon and issue related stop transfer instructions. 

The Stockholder acknowledges and understands that the Shares have not been registered under the Securities Act, nor registered pursuant to the
provisions of the securities laws or other laws of any other applicable jurisdictions, in reliance on exemptions for private offerings contained in the Securities Act and in the laws of such jurisdictions. The Stockholder further understands that
the Company has no intention and is under no obligation to register the Shares under the Securities Act or to comply with the requirements for any exemption that might 

  
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otherwise be available, or to supply the Stockholder with any information necessary to enable the Stockholder to make routine sales of the Shares under Rule 144 promulgated under the Securities
Act or any other rule of the Securities and Exchange Commission. 
 7. Miscellaneous. 

(a) Notices. All notices to be given or otherwise made to any party to this Agreement shall be deemed to be sufficient if contained in
a written instrument, delivered by hand in person, or by express overnight courier service, or by electronic transmission, or by registered or certified mail, return receipt requested, postage prepaid, addressed, if to the Stockholder, to the
address set forth on the cover page or at the address shown on the records of the Company, and if to the Company, to the Company’s principal executive offices, attention of the President. 

(b) Entire Agreement; Modification. This Agreement constitutes the entire agreement between the parties relative to the subject matter
hereof, and supersedes all proposals, written or oral, and all other communications between the parties relating to the subject matter of this Agreement. This Agreement may be modified, amended or rescinded only by a written agreement executed by
both parties. 
 (c) Waivers. From time to time, a party may waive its rights hereunder either generally or with respect to one or
more specific transfers or actions that have been proposed, attempted or made. No waiver of any breach or default hereunder shall be considered valid unless in writing, and no such waiver shall be deemed a waiver of any subsequent breach or default
of the same or similar nature. 
 (d) Changes in Capital Structure. In the event of any stock split, stock dividend, extraordinary
cash dividend, recapitalization, reorganization, merger, consolidation, combination, exchange of shares, liquidation, spin-off, split-up, automatic conversion into voting common stock of the Company pursuant to the certificate of incorporation of
the Company or other similar change in capitalization or event, (i) the number of Shares, including the number vesting on each subsequent vesting date hereunder, shall be appropriately adjusted by the Company, (ii) the securities received
in respect of such event shall be “Shares” hereunder subject to this Agreement and shall retain the same status as “Vested Shares” or “Unvested Shares” as the Shares in respect of which they were received, and
(iii) the repurchase price per security subject to repurchase shall be appropriately adjusted by the Company, in each case to the extent that the Board shall determine, in good faith, that such adjustment is appropriate. 

(e) Lock-up Agreement. The Stockholder agrees that in the event that the Company effects an initial underwritten public offering of
common stock registered under the Securities Act, the Shares may not be sold, offered for sale or otherwise disposed of, directly or indirectly, without the prior written consent of the managing underwriter(s) of the offering, for such period of
time (not to exceed one hundred eighty (180) days) after the execution of an underwriting agreement in connection with such offering that all of the Company’s then directors and executive officers agree to be similarly bound. 

(f) Severability. The invalidity, illegality or unenforceability of any provision of this Agreement shall in no way affect the
validity, legality or enforceability of any other provision. 

  
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 (g) Successors and Assigns. This Agreement shall be binding upon and inure to the benefit
of the parties hereto and their respective successors and assigns, subject to the limitations set forth herein. 
 (h) Governing Law;
Forum Selection Clause. This Agreement and any claims arising out of this Agreement (or any other claims arising out of the relationship between the parties) shall be governed by and construed in accordance with the laws of the Commonwealth of
Massachusetts and shall in all respects be interpreted, enforced and governed under the internal and domestic laws of such state, without giving effect to the principles of conflicts of laws of such state. 

(i) No Obligation to Continue Business Relationship. Neither this Agreement nor any provision hereof imposes any obligation on the
Company to continue the Stockholder in any Business Relationship with the Company. 
 (j) Counterparts. This Agreement may be
executed in two or more counterparts, each one of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 

  
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 Exhibit 10.28 

CIVITAS THERAPEUTICS, INC. 

2014 EQUITY INCENTIVE PLAN 
  

	1.	DEFINED TERMS 

 Exhibit A, which is incorporated by reference, defines the terms
used in the Plan and sets forth certain operational rules related to those terms. 
  

	2.	PURPOSE 

 The Plan has been established to advance the interests of the Company by
providing for the grant to Participants of Stock-based Awards. 
  

	3.	ADMINISTRATION 

 The Administrator has discretionary authority, subject only to the
express provisions of the Plan, to interpret the Plan; determine eligibility for and grant Awards; determine, modify or waive the terms and conditions of any Award; determine the form of settlement of Awards (whether in cash, shares of Stock or
other property); prescribe forms, rules and procedures relating to the Plan; and otherwise do all things necessary or appropriate to carry out the purposes of the Plan. Determinations of the Administrator made under the Plan will be conclusive and
will bind all persons. 
  

	4.	LIMITS ON AWARDS UNDER THE PLAN 

 (a) Number of Shares. Subject to
adjustment as provided in Section 7(b), the maximum number of shares of Stock that may be delivered in satisfaction of Awards under the Plan is 1,760,000 shares (the “Share Pool”). The Share Pool shall automatically increase annually
on each January 1st, from January 1, 2015 through January 1, 2024, in an amount equal to four percent (4%) of the number of shares of Stock outstanding as of the close of
business on the immediately preceding December 31st. Notwithstanding the foregoing, the Board may act prior to January 1st of a given year to provide that there will be no
January 1st increase in the Share Pool for such year or that the increase in the Share Pool for such year will be a lesser number of shares of Stock than would otherwise occur pursuant to the preceding sentence. Notwithstanding the preceding
sentences, subject to adjustment as provided in Section 7(b), no more than 13,298,890 shares of Stock may be delivered in satisfaction of ISOs awarded under the Plan. Nothing in this Section 4(a) will be construed as requiring that any, or
any fixed number of, ISOs be awarded under the Plan. The limits set forth in this Section 4(a) shall be construed to comply with Section 422 of the Code. For purposes of this Section 4(a), the number of shares of Stock delivered in
satisfaction of Awards will be determined net of shares of Stock withheld by the Company in payment of the exercise price of the Award or in satisfaction of tax withholding requirements with respect to the Award and, for the avoidance of doubt,
without including any shares of Stock underlying Awards settled in cash or that otherwise expire or become unexercisable without having been exercised or that are forfeited to or repurchased by the Company due to failure to vest. To the extent
consistent with the requirements of Section 422 and the regulations thereunder, and with other applicable legal requirements (including applicable stock exchange requirements), Stock issued under awards of an acquired company that are
converted, replaced or adjusted in connection with the acquisition shall not reduce the number of shares of Stock available for Awards under the Plan. 

 (b) Type of Shares. Stock delivered by the Company under the Plan may be authorized
but unissued Stock or previously issued Stock acquired by the Company. No fractional shares of Stock will be delivered under the Plan. 

(c) Individual Limits. The following additional limits will apply to Awards of the specified type granted to any person in any
calendar year: 
  

	 	(1)	Stock Options: 600,000 shares of Stock. 

  

	 	(2)	SARs: 600,000 shares of Stock. 

  

	 	(3)	Awards other than Stock Options or SARs: 600,000 shares of Stock. 

 In applying the
foregoing limits, (i) all Awards of the specified type granted to the same person in the same calendar year will be aggregated and made subject to one limit; (ii) the share limits applicable to Stock Options and SARs refer to the number of
shares of Stock subject to those Awards; and (iii) the share limit under clause (3) refers to the maximum number of shares of Stock that may be delivered, or the value of which could be paid in cash or other property, under an Award or
Awards of the type specified in clause (3) assuming a maximum payout. The foregoing provisions will be construed in a manner consistent with Section 162(m), including, without limitation, where applicable, the rules under
Section 162(m) pertaining to permissible deferrals of exempt awards. 
 (d) Notwithstanding any other provision of the Plan to
the contrary, including subsection (c) above, in the case of a non-employee Director, additional limits shall apply such that the maximum grant-date fair value of Awards granted in any calendar year during any part of which the Director is then
eligible under the Plan shall be $400,000, except that such limit for a non-employee Chairman of the Board or lead Director shall be $600,000, in each case, computed in accordance with FASB ASC Topic 718. The foregoing additional limits related to
non-employee Directors of the Company shall not apply to any Award or shares of Stock granted pursuant to a non-employee Director’s election to receive an Award or shares of Stock in lieu of cash retainers or other fees (to the extent such
Award or shares of Stock have a fair value equal to the value of such cash retainers or other fees). 
  

	5.	ELIGIBILITY AND PARTICIPATION 

 The Administrator will select Participants from among key
Employees and Directors of, and consultants and advisors to, the Company and its Affiliates who are in a position to contribute significantly to the success of the Company and its Affiliates. Eligibility for ISOs is limited to individuals described
in the first sentence of this Section 5 who are employees of the Company or of a “parent corporation” or “subsidiary corporation” of the Company as those terms are defined in Section 424 of the Code. Eligibility for
Stock Options other than ISOs is limited to individuals described in the first sentence of this Section 5 who are providing direct services on the date of grant of the Stock Option to the Company or to a subsidiary of the Company that would be
described in the first sentence of Treas. Regs. §1.409A-1(b)(5)(iii)(E). 

  
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	6.	RULES APPLICABLE TO AWARDS 

  

	 	(a)	All Awards. 

 (1) Award Provisions. The Administrator will determine
the terms of all Awards, subject to the limitations provided herein. By accepting (or, under such rules as the Administrator may prescribe, being deemed to have accepted) an Award, the Participant will be deemed to have agreed to the terms of the
Award and the Plan. Notwithstanding any provision of this Plan to the contrary, awards of an acquired company that are converted, replaced or adjusted in connection with the acquisition may contain terms and conditions that are inconsistent with the
terms and conditions specified herein, as determined by the Administrator. 
 (2) Term of Plan. No Awards may be made after
ten years from the Date of Adoption, but previously granted Awards may continue beyond that date in accordance with their terms. 
 (3)
Transferability. Neither ISOs nor, except as the Administrator otherwise expressly provides in accordance with the third sentence of this Section 6(a)(3), other Awards may be transferred other than by will or by the laws of descent
and distribution. During a Participant’s lifetime, ISOs (and, except as the Administrator otherwise expressly provides in accordance with the third sentence of this Section 6(a)(3), SARs and NSOs) may be exercised only by the Participant.
The Administrator may permit the gratuitous transfer (i.e., transfer not for value) of Awards other than ISOs, subject to such limitations as the Administrator may impose. 

(4) Vesting, etc. The Administrator will determine the time or times at which an Award will vest or become exercisable and the
terms on which a Stock Option or SAR will remain exercisable. Without limiting the foregoing, the Administrator may at any time accelerate the vesting or exercisability of an Award, regardless of any adverse or potentially adverse tax or other
consequences resulting from such acceleration. Unless the Administrator expressly provides otherwise, however, the following rules will apply if a Participant’s Employment ceases: 

(A) Immediately upon the cessation of the Participant’s Employment and except as provided in (B) and
(C) below, each Stock Option and SAR that is then held by the Participant or by the Participant’s permitted transferees, if any, will cease to be exercisable and will terminate and all other Awards that are then held by the Participant or
by the Participant’s permitted transferees, if any, to the extent not already vested will be forfeited. 
 (B)
Subject to (C) and (D) below, all Stock Options and SARs held by the Participant or the Participant’s permitted transferees, if any, immediately prior to the cessation of the Participant’s Employment, to the extent then
exercisable, will remain exercisable for the lesser of (i) a period of three months or (ii) the period ending on the latest date on which such Stock Option or SAR could have been exercised without regard to this Section 6(a)(4), and
will thereupon immediately terminate. 

  
 3 

 (C) All Stock Options and SARs held by a Participant or the
Participant’s permitted transferees, if any, immediately prior to the cessation of the Participant’s Employment due to his or her death, to the extent then exercisable, will remain exercisable for the lesser of (i) a period of twelve
(12) months or (ii) the period ending on the latest date on which such Stock Option or SAR could have been exercised without regard to this Section 6(a)(4), and will thereupon immediately terminate. 

(D) All Stock Options and SARs (whether or not exercisable) held by a Participant or the Participant’s permitted
transferees, if any, immediately prior to the cessation of the Participant’s Employment will immediately terminate upon such cessation of Employment if the termination is for Cause or occurs in circumstances that in the sole determination of
the Administrator would have constituted grounds for the Participant’s Employment to be terminated for Cause. 
 (5) Additional
Restrictions. The Administrator may cancel, rescind, withhold or otherwise limit or restrict any Award at any time if the Participant is not in compliance with all applicable provisions of the Award agreement and the Plan, or if the
Participant breaches any agreement with the Company or its Affiliates with respect to non-competition, non-solicitation or confidentiality. Without limiting the generality of the foregoing, the Administrator may recover Awards made under the Plan
and payments under or gain or shares of stock delivered in respect of any Award in accordance with any applicable Company clawback or recoupment policy, as such policy may be amended and in effect from time to time, or as otherwise required by
applicable law or applicable stock exchange listing standards, including, without limitation, Section 10D of the Securities Exchange Act of 1934, as amended. 

(6) Taxes. The delivery, vesting and retention of Stock, cash or other property under an Award are conditioned upon full
satisfaction by the Participant of all tax withholding requirements with respect to the Award. The Administrator will prescribe such rules for the withholding of taxes as it deems necessary. The Administrator may, but need not, hold back shares of
Stock from an Award or permit a Participant to tender previously owned shares of Stock in satisfaction of tax withholding requirements (but not in excess of the minimum withholding required by law). 

(7) Dividend Equivalents, Etc. The Administrator may provide for the payment of amounts (on terms and subject to conditions
established by the Administrator) in lieu of cash dividends or other cash distributions with respect to Stock subject to an Award whether or not the holder of such Award is otherwise entitled to share in the actual dividend or distribution in
respect of such Award. Any entitlement to dividend equivalents or similar entitlements will be established and administered either consistent with an exemption from, or in compliance with, the requirements of Section 409A. Dividends or dividend
equivalent amounts payable in respect of Awards that are subject to restrictions may be subject to such limits or restrictions as the Administrator may impose. 

(8) Rights Limited. Nothing in the Plan will be construed as giving any person the right to continued employment or service with
the Company or its Affiliates, or any rights as a stockholder except as to shares of Stock actually issued under the Plan. The loss of existing or potential profit in Awards will not constitute an element of damages in the event of a termination of
Employment for any reason, even if the termination is in violation of an obligation of the Company or any Affiliate to the Participant. 

  
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 (9) Section 162(m). In the case of any Performance Award (other than a Stock
Option or SAR) intended to qualify for the performance-based compensation exception under Section 162(m), the Administrator will establish the applicable Performance Criterion or Criteria in writing no later than ninety (90) days after the
commencement of the period of service to which the performance relates (or at such earlier time as is required to qualify the Award as performance-based under Section 162(m)) and, prior to the event or occurrence (grant, vesting or payment, as
the case may be) that is conditioned on the attainment of such Performance Criterion or Criteria, will certify whether it or they have been attained. The preceding sentence will not apply to an Award eligible (as determined by the Administrator) for
exemption from the limitations of Section 162(m) by reason of the post-initial public offering transition relief in Section 1.162-27(f) of the Treasury Regulations. 

(10) Coordination with Other Plans. Awards under the Plan may be granted in tandem with, or in satisfaction of or substitution
for, other Awards under the Plan or awards made under other compensatory plans or programs of the Company or its Affiliates. For example, but without limiting the generality of the foregoing, awards under other compensatory plans or programs of the
Company or its Affiliates may be settled in Stock (including, without limitation, Unrestricted Stock) if the Administrator so determines, in which case the shares delivered will be treated as awarded under the Plan (and will reduce the number of
shares thereafter available under the Plan in accordance with the rules set forth in Section 4). In any case where an award is made under another plan or program of the Company or its Affiliates and such award is intended to qualify for the
performance-based compensation exception under Section 162(m), and such award is settled by the delivery of Stock or another Award under the Plan, the applicable Section 162(m) limitations under both the other plan or program and under the
Plan will be applied to the Plan as necessary (as determined by the Administrator) to preserve the availability of the Section 162(m) performance-based compensation exception with respect thereto. 

(11) Section 409A. Each Award will contain such terms as the Administrator determines, and will be construed and
administered, such that the Award either qualifies for an exemption from the requirements of Section 409A or satisfies such requirements. 

(12) Fair Market Value. In determining the fair market value of any share of Stock under the Plan, the Administrator will make
the determination in good faith consistent with the rules of Section 422 and Section 409A, to the extent applicable. 
  

	 	(b)	Stock Options and SARs. 

 (1) Time and Manner of Exercise. Unless
the Administrator expressly provides otherwise, no Stock Option or SAR will be deemed to have been exercised until the Administrator receives a notice of exercise (in form acceptable to the Administrator), which may be an electronic notice, signed
(including electronic signature in form acceptable to the Administrator) by the appropriate person and accompanied by any payment required under the Award. A Stock Option or SAR exercised by any person other than the Participant will not be deemed
to have been exercised until the Administrator has received such evidence as it may require that the person exercising the Award has the right to do so. 

  
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 (2) Exercise Price. The exercise price (or the base value from which appreciation
is to be measured) of each Award requiring exercise will be no less than 100% (or in the case of an ISO granted to a ten-percent shareholder within the meaning of subsection (b)(6) of Section 422, 110%) of the fair market value of the Stock
subject to the Award, determined as of the date of grant, or such higher amount as the Administrator may determine in connection with the grant. Except in connection with a corporate transaction involving the Company (which term shall include,
without limitation, any stock dividend, stock split, extraordinary cash dividend, recapitalization, reorganization, merger, consolidation, split-up, spin-off, combination, or exchange of shares) or as otherwise contemplated by Section 7 of the
Plan, the terms of outstanding Stock Options or SARs, as applicable, may not be amended to reduce the exercise prices of such Stock Options or the base values from which appreciation under such SARs are to be measured other than in accordance with
the stockholder approval requirements of the NASDAQ Global Market. 
 (3) Payment of Exercise Price. Where the exercise of an
Award is to be accompanied by payment, payment of the exercise price will be by cash or check acceptable to the Administrator or by such other legally permissible means, if any, as may be acceptable to the Administrator. 

(4) Maximum Term. Stock Options and SARs will have a maximum term not to exceed ten (10) years from the date of grant (or
five (5) years from the date of grant in the case of an ISO granted to a ten-percent shareholder described in Section 6(b)(2) above); provided, however, that, if a Participant still holding an outstanding but unexercised NSO or SAR ten
(10) years from the date of grant (or, in the case of an NSO or SAR with a maximum term of less than ten (10) years, such maximum term) is prohibited by applicable law or a written policy of the Company applicable to similarly situated
employees from engaging in any open-market sales of Stock, and if at such time the Stock is publicly traded (as determined by the Administrator), the maximum term of such Award will instead be deemed to expire on the thirtieth (30th) day following the date the Participant is no longer prohibited from engaging in such open market sales. 
  

	7.	EFFECT OF CERTAIN TRANSACTIONS 

 (a) Mergers, etc.
Except as otherwise provided in an Award agreement, the following provisions will apply in the event of a Covered Transaction: 
 (1)
Assumption or Substitution. If the Covered Transaction is one in which there is an acquiring or surviving entity, the Administrator may (but, for the avoidance of doubt, need not) provide (i) for the assumption or continuation of
some or all outstanding Awards or any portion thereof or (ii) for the grant of new awards in substitution therefor by the acquiror or survivor or an affiliate of the acquiror or survivor. 

(2) Cash-Out of Awards. Subject to Section 7(a)(5) below the Administrator may (but, for the avoidance of doubt, need not)
provide for payment (a “cash-out”), with respect 

  
 6 

 
to some or all Awards or any portion thereof, equal in the case of each affected Award or portion thereof to the excess, if any, of (A) the fair market value of one share of Stock (as
determined by the Administrator in its reasonable discretion) times the number of shares of Stock subject to the Award or such portion, over (B) the aggregate exercise or purchase price, if any, under the Award or such portion (in the case of
an SAR, the aggregate base value above which appreciation is measured), in each case on such payment terms (which need not be the same as the terms of payment to holders of Stock) and other terms, and subject to such conditions, as the Administrator
determines; it being understood that if the exercise or purchase price (or base value) of an Award is equal to or greater than the fair market value of one share of Stock, the Award may be cancelled with no payment due hereunder. 

(3) Acceleration of Certain Awards. Subject to Section 7(a)(5) below, the Administrator may (but, for the avoidance of
doubt, need not) provide that any Award requiring exercise will become exercisable, in full or in part, and/or that the delivery of any shares of Stock remaining deliverable under any outstanding Award of Stock Units (including Restricted Stock
Units and Performance Awards to the extent consisting of Stock Units) will be accelerated in full or in part, in each case on a basis that gives the holder of the Award a reasonable opportunity, as determined by the Administrator, following exercise
of the Award or the delivery of the shares, as the case may be, to participate as a stockholder in the Covered Transaction. 
 (4)
Termination of Awards upon Consummation of Covered Transaction. Except as the Administrator may otherwise determine in any case, each Award will automatically terminate (and in the case of outstanding shares of Restricted Stock, will
automatically be forfeited) upon consummation of the Covered Transaction, other than Awards assumed pursuant to Section 7(a)(1) above. 

(5) Additional Limitations. Any share of Stock and any cash or other property delivered pursuant to Section 7(a)(2) or
Section 7(a)(3) above with respect to an Award may, in the discretion of the Administrator, contain such restrictions, if any, as the Administrator deems appropriate to reflect any performance or other vesting conditions to which the Award was
subject and that did not lapse (and were not satisfied) in connection with the Covered Transaction. For purposes of the immediately preceding sentence, a cash-out under Section 7(a)(2) above or acceleration under Section 7(a)(3) above will
not, in and of itself, be treated as the lapsing (or satisfaction) of a performance or other vesting condition. In the case of Restricted Stock that does not vest and is not forfeited in connection with the Covered Transaction, the Administrator may
require that any amounts delivered, exchanged or otherwise paid in respect of such Stock in connection with the Covered Transaction be placed in escrow or otherwise made subject to such restrictions as the Administrator deems appropriate to carry
out the intent of the Plan. 
  

	 	(b)	Changes in and Distributions with Respect to Stock. 

 (1) Basic Adjustment
Provisions. In the event of a stock dividend, stock split or combination of shares (including a reverse stock split), recapitalization or other change in the Company’s capital structure that constitutes an equity restructuring within
the meaning of FASB ASC 718, the Administrator will make appropriate adjustments to the Share Pool, to the maximum number of shares of Stock that may be delivered in satisfaction of ISOs under the 

  
 7 

 
Plan, and to the maximum share limits described in Section 4(c) and Section 4(d), and will also make appropriate adjustments to the number and kind of shares of stock or securities
subject to Awards then outstanding or subsequently granted, any exercise or purchase prices (or base values) relating to Awards and any other provision of Awards affected by such change. 

(2) Certain Other Adjustments. The Administrator may also make adjustments of the type described in Section 7(b)(1) above
to take into account distributions to stockholders other than those provided for in Section 7(a) and 7(b)(1), or any other event, if the Administrator determines that adjustments are appropriate to avoid distortion in the operation of the Plan,
having due regard for the qualification of ISOs under Section 422, the requirements of Section 409A, and for the performance-based compensation rules of Section 162(m), where applicable. 

(3) Continuing Application of Plan Terms. References in the Plan to shares of Stock will be construed to include any stock or
securities resulting from an adjustment pursuant to this Section 7. 
  

	8.	LEGAL CONDITIONS ON DELIVERY OF STOCK 

 The Company will not be obligated to deliver any
shares of Stock pursuant to the Plan or to remove any restriction from shares of Stock previously delivered under the Plan until: (i) the Company is satisfied that all legal matters in connection with the issuance and delivery of such shares
have been addressed and resolved; (ii) if the outstanding Stock is at the time of delivery listed on any stock exchange or national market system, the shares to be delivered have been listed or authorized to be listed on such exchange or system
upon official notice of issuance; and (iii) all conditions of the Award have been satisfied or waived. The Company may require, as a condition to exercise of the Award, such representations or agreements as counsel for the Company may consider
appropriate to avoid violation of the Securities Act of 1933, as amended, or any applicable state or non-U.S. securities law. Any Stock required to be issued to Participants under the Plan will be evidenced in such manner as the Administrator may
deem appropriate, including book-entry registration or delivery of stock certificates. In the event that the Administrator determines that Stock certificates will be issued to Participants under the Plan, the Administrator may require that
certificates evidencing Stock issued under the Plan bear an appropriate legend reflecting any restriction on transfer applicable to such Stock, and the Company may hold the certificates pending lapse of the applicable restrictions. 

 

	9.	AMENDMENT AND TERMINATION 

 The Administrator may at any time or times amend the Plan or
any outstanding Award for any purpose which may at the time be permitted by law, and may at any time terminate the Plan as to any future grants of Awards; provided, that, except as otherwise expressly provided in the Plan, the Administrator may not,
without the Participant’s consent, alter the terms of an Award so as to affect materially and adversely the Participant’s rights under the Award, unless the Administrator expressly reserved the right to do so at the time the Award was
granted. Any amendments to the Plan will be conditioned upon stockholder approval only to the extent, if any, such approval is required by law (including the Code and applicable stock exchange requirements), as determined by the Administrator. 

  
 8 

	10.	OTHER COMPENSATION ARRANGEMENTS 

 The existence of the Plan or the grant of any Award
will not in any way affect the Company’s right to Award a person bonuses or other compensation in addition to Awards under the Plan. 
  

	11.	MISCELLANEOUS 

 (a) Waiver of Jury Trial. By accepting an Award under the
Plan, each Participant waives any right to a trial by jury in any action, proceeding or counterclaim concerning any rights under the Plan and any Award, or under any amendment, waiver, consent, instrument, document or other agreement delivered or
which in the future may be delivered in connection therewith, and agrees that any such action, proceedings or counterclaim will be tried before a court and not before a jury. By accepting an Award under the Plan, each Participant certifies that no
officer, representative, or attorney of the Company has represented, expressly or otherwise, that the Company would not, in the event of any action, proceeding or counterclaim, seek to enforce the foregoing waivers. Notwithstanding anything to the
contrary in the Plan, nothing herein is to be construed as limiting the ability of the Company and a Participant to agree to submit disputes arising under the terms of the Plan or any Award made hereunder to binding arbitration or as limiting the
ability of the Company to require any eligible individual to agree to submit such disputes to binding arbitration as a condition of receiving an Award hereunder. 

(b) Limitation of Liability. Notwithstanding anything to the contrary in the Plan, neither the Company, nor any Affiliate, nor
the Administrator, nor any person acting on behalf of the Company, any Affiliate, or the Administrator, will be liable to any Participant or to the estate or beneficiary of any Participant or to any other holder of an Award by reason of any
acceleration of income, or any additional tax (including any interest and penalties), asserted by reason of the failure of an Award to satisfy the requirements of Section 422 or Section 409A or by reason of Section 4999 of the Code,
or otherwise asserted with respect to the Award. 
  

	12.	ESTABLISHMENT OF SUB-PLANS 

 The Administrator may from time to time establish one or
more sub-plans under the Plan for purposes of satisfying applicable blue sky, securities or tax laws of various jurisdictions. The Administrator will establish such sub-plans by adopting supplements to the Plan setting forth (i) such
limitations on the Administrator’s discretion under the Plan as it deems necessary or desirable and (ii) such additional terms and conditions not otherwise inconsistent with the Plan as it deems necessary or desirable. All supplements so
established will be deemed to be part of the Plan, but each supplement will apply only to Participants within the affected jurisdiction (as determined by the Administrator). 
  

	13.	GOVERNING LAW 

 (a) Certain Requirements of Corporate Law. Awards will be
granted and administered consistent with the requirements of applicable Delaware law relating to the issuance of stock and the consideration to be received therefor, and with the applicable requirements of the stock exchanges or other trading
systems on which the Stock is listed or entered for trading, in each case as determined by the Administrator. 

  
 9 

 (b) Other Matters. Except as otherwise provided by the express terms of an Award
agreement, under a sub-plan described in Section 12 or as provided in Section 13(a) above, the provisions of the Plan and of Awards under the Plan and all claims or disputes arising out of or based upon the Plan or any Award under the Plan
or relating to the subject matter hereof or thereof will be governed by and construed in accordance with the domestic substantive laws of the State of Massachusetts without giving effect to any choice or conflict of laws provision or rule that would
cause the application of the domestic substantive laws of any other jurisdiction. 
 (c) Jurisdiction. By accepting an Award,
each Participant will be deemed to (a) have submitted irrevocably and unconditionally to the jurisdiction of the federal and state courts located within the geographic boundaries of the United States District Court for the District of
Massachusetts for the purpose of any suit, action or other proceeding arising out of or based upon the Plan or any Award; (b) agree not to commence any suit, action or other proceeding arising out of or based upon the Plan or an Award, except
in the federal and state courts located within the geographic boundaries of the United States District Court for the District of Massachusetts; and (c) waive, and agree not to assert, by way of motion as a defense or otherwise, in any such
suit, action or proceeding, any claim that it is not subject personally to the jurisdiction of the above-named courts that its property is exempt or immune from attachment or execution, that the suit, action or proceeding is brought in an
inconvenient forum, that the venue of the suit, action or proceeding is improper or that the Plan or an Award or the subject matter thereof may not be enforced in or by such court. 

  
 10 

 EXHIBIT A 

Definition of Terms 

The following terms, when used in the Plan, will have the meanings and be subject to the provisions set forth below: 

“Administrator”: The Compensation Committee, except that the Compensation Committee may delegate (i) to one or more of
its members (or one or more other members of the Board (including the full Board)) such of its duties, powers and responsibilities as it may determine; (ii) to one or more officers of the Company the power to grant Awards to the extent
permitted by Section 157(c) of the Delaware General Corporation Law; and (iii) to such Employees or other persons as it determines such ministerial tasks as it deems appropriate. In the event of any delegation described in the preceding
sentence, the term “Administrator” will include the person or persons so delegated to the extent of such delegation. 

“Affiliate”: Any corporation or other entity that stands in a relationship to the Company that would result in the Company
and such corporation or other entity being treated as one employer under Section 414(b) and Section 414(c) of the Code. 

“Award”: Any or a combination of the following: 

(i) Stock Options. 

(ii) SARs. 

(iii) Restricted Stock. 

(iv) Unrestricted Stock. 

(v) Stock Units, including Restricted Stock Units. 

(vi) Performance Awards. 

(vii) Awards (other than Awards described in (i) through (vi) above) that are convertible into or otherwise based on
Stock. 
 “Board”: The Board of Directors of the Company. 

“Cause”: In the case of any Participant who is party to an employment or severance-benefit agreement that contains a
definition of “Cause,” the definition set forth in such agreement will apply with respect to such Participant under the Plan for so long as such agreement is in effect. In the case of any other Participant, “Cause” will mean, as
determined by the Administrator in its reasonable judgment, (i) a substantial failure of the Participant to perform the Participant’s duties and responsibilities to the Company or subsidiaries or substantial negligence in the performance
of such duties and responsibilities; (ii) the commission by the Participant of a felony or a crime involving moral turpitude; (iii) the commission by the Participant of theft, fraud, embezzlement, material breach of trust or any material
act of 

  
 11 

 
dishonesty involving the Company or any of its subsidiaries; (iv) a significant violation by the Participant of the code of conduct of the Company or its subsidiaries of any material policy
of the Company or its subsidiaries, or of any statutory or common law duty of loyalty to the Company or its subsidiaries; (v) material breach of any of the terms of the Plan or any Award made under the Plan, or of the terms of any other
agreement between the Company or subsidiaries and the Participant; or (vi) other conduct by the Participant that could reasonably be expected to be harmful to the business, interests or reputation of the Company. 

“Code”: The U.S. Internal Revenue Code of 1986 as from time to time amended and in effect, or any successor statute as from
time to time in effect. 
 “Compensation Committee”: The Compensation Committee of the Board. 

“Company”: Civitas Therapeutics, Inc. 

“Covered Transaction”: Any of (i) a consolidation, merger, or similar transaction or series of related transactions,
including a sale or other disposition of stock, in which the Company is not the surviving corporation or that results in the acquisition of all or substantially all of the Company’s then outstanding common stock by a single person or entity or
by a group of persons and/or entities acting in concert, (ii) a sale or transfer of all or substantially all the Company’s assets, or (iii) a dissolution or liquidation of the Company. Where a Covered Transaction involves a tender
offer that is reasonably expected to be followed by a merger described in clause (i) (as determined by the Administrator), the Covered Transaction will be deemed to have occurred upon consummation of the tender offer. 

“Date of Adoption”: The earlier of the date the Plan was approved by the Company’s stockholders or adopted by the Board,
as determined by the Compensation Committee. 
 “Director”: A member of the Board. 

“Employee”: Any person who is employed by the Company or an Affiliate. 

“Employment”: A Participant’s employment or other service relationship with the Company and its Affiliates. Employment
will be deemed to continue, unless the Administrator expressly provides otherwise, so long as the Participant is employed by, or otherwise is providing services in a capacity described in Section 5 to the Company or an Affiliate. If a
Participant’s employment or other service relationship is with an Affiliate and that entity ceases to be an Affiliate, the Participant’s Employment will be deemed to have terminated when the entity ceases to be an Affiliate unless the
Participant transfers Employment to the Company or its remaining Affiliates. Notwithstanding the foregoing and the definition of “Affiliate” above, in construing the provisions of any Award relating to the payment of “nonqualified
deferred compensation” (subject to Section 409A) upon a termination or cessation of Employment, references to termination or cessation of employment, separation from service, retirement or similar or correlative terms will be construed to
require a “separation from service” (as that term is defined in Section 1.409A-1(h) of the Treasury Regulations, after giving effect to the presumptions contained therein) from the Company and from all other corporations and trades or
businesses, if any, that would be treated as a single “service recipient” with the Company under Section 1.409A-1(h)(3) of the Treasury Regulations. The Company may, but need not, elect in

  
 12 

 
writing, subject to the applicable limitations under Section 409A, any of the special elective rules prescribed in Section 1.409A-1(h) of the Treasury Regulations for purposes of
determining whether a “separation from service” has occurred. Any such written election will be deemed a part of the Plan. 

“ISO”: A Stock Option intended to be an “incentive stock option” within the meaning of Section 422. Each Stock
Option granted pursuant to the Plan will be treated as providing by its terms that it is to be an NSO unless, as of the date of grant, it is expressly designated as an ISO. 

“NSO”: A Stock Option that is not intended to be an “incentive stock option” within the meaning of
Section 422. 
 “Participant”: A person who is granted an Award under the Plan. 

“Performance Award”: An Award subject to Performance Criteria. The Administrator in its discretion may grant Performance
Awards that are intended to qualify for the performance-based compensation exception under Section 162(m) and Performance Awards that are not intended so to qualify. 

“Performance Criteria”: Specified criteria, other than the mere continuation of Employment or the mere passage of time, the
satisfaction of which is a condition for the grant, exercisability, vesting or full enjoyment of an Award. For purposes of Awards that are intended to qualify for the performance-based compensation exception under Section 162(m), a Performance
Criterion will mean an objectively determinable measure or measures of performance relating to any or any combination of the following (measured either absolutely or by reference to an index or indices and determined either on a consolidated basis
or, as the context permits, on a divisional, subsidiary, line of business, project or geographical basis or in combinations thereof): sales; revenues; assets; expenses; earnings before or after deduction for all or any portion of interest, taxes,
depreciation, amortization or equity expense, whether or not on a continuing operations or an aggregate or per share basis; return on equity, investment, capital, capital employed or assets; one or more operating ratios; operating income or profit,
including on an after-tax basis; net income; borrowing levels, leverage ratios or credit rating; market share; capital expenditures; cash flow; stock price; stockholder return; sales of particular products or services; customer acquisition or
retention; acquisitions and divestitures (in whole or in part); joint ventures, strategic alliances, licenses or collaborations; spin-offs, split-ups and the like; reorganizations; recapitalizations, restructurings, financings (issuance of debt or
equity) or refinancings; manufacturing or process development; or achievement of clinical trial or research objectives, regulatory or other filings or approvals or other product development milestones. A Performance Criterion and any targets with
respect thereto determined by the Administrator need not be based upon an increase, a positive or improved result or avoidance of loss. To the extent consistent with the requirements for satisfying the performance-based compensation exception under
Section 162(m), the Administrator may provide in the case of any Award intended to qualify for such exception that one or more of the Performance Criteria applicable to such Award will be adjusted in an objectively determinable manner to
reflect events (for example, the impact of charges for restructurings, discontinued operations, mergers, acquisitions, extraordinary items, and other unusual or non-recurring items, and the cumulative effects of tax or accounting changes, each as
defined by U.S. generally accepted accounting principles) occurring during the performance period that affect the applicable Performance Criterion or Criteria. 

  
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 “Plan”: The Civitas Therapeutics, Inc. 2014 Equity Incentive Plan as from time
to time amended and in effect. 
 “Restricted Stock”: Stock subject to restrictions requiring that it be redelivered or
offered for sale to the Company if specified conditions are not satisfied. 
 “Restricted Stock Unit”: A Stock Unit that
is, or as to which the delivery of Stock or cash in lieu of Stock is, subject to the satisfaction of specified performance or other vesting conditions. 

“SAR”: A right entitling the holder upon exercise to receive an amount (payable in cash or in shares of Stock of equivalent
value) equal to the excess of the fair market value of the shares of Stock subject to the right over the base value from which appreciation under the SAR is to be measured. 

“Section 409A”: Section 409A of the Code. 

“Section 422”: Section 422 of the Code. 

“Section 162(m)”: Section 162(m) of the Code. 

“Stock”: Common stock of the Company, par value $0.001 per share. 

“Stock Option”: An option entitling the holder to acquire shares of Stock upon payment of the exercise price. 

“Stock Unit”: An unfunded and unsecured promise, denominated in shares of Stock, to deliver Stock or cash measured by the
value of Stock in the future. 
 “Unrestricted Stock”: Stock not subject to any restrictions under the terms of the Award.

  
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