Document:

Loan and Security Agreement

 Exhibit 10.1 
  
  
 TPTX, INC. 
 LOAN AND SECURITY AGREEMENT 
  
  

 This LOAN AND SECURITY AGREEMENT is entered into as of June 11, 2008, by and between COMERICA BANK
(“Bank”) and TPTX, INC. (“Borrower”). 
 RECITALS 
 Borrower wishes to obtain credit from time to time from Bank, and Bank desires to extend credit to Borrower. This Agreement sets forth the terms on which
Bank will advance credit to Borrower, and Borrower will repay the amounts owing to Bank. 
 AGREEMENT 
 The parties agree as follows: 
 1.
DEFINITIONS AND CONSTRUCTION. 
 1.1 Definitions. As used in this Agreement, the following terms shall have the
following definitions: 
 “Accounts” means all presently existing and hereafter arising accounts, contract rights,
payment intangibles, and all other forms of obligations owing to Borrower arising out of the sale or lease of goods (including, without limitation, the licensing of software and other technology) or the rendering of services by Borrower, whether or
not earned by performance, and any and all credit insurance, guaranties, and other security therefor, as well as all merchandise returned to or reclaimed by Borrower and Borrower’s Books relating to any of the foregoing. 
 “Affiliate” means, with respect to any Person, any Person that owns or controls directly or indirectly such Person, any Person
that controls or is controlled by or is under common control with such Person, and each of such Person’s senior executive officers, directors, and partners. 
 “Bank Expenses” means all reasonable costs or expenses (including reasonable attorneys’ fees and expenses, whether
generated in-house or by outside counsel) incurred in connection with the preparation, negotiation, administration, and enforcement of the Loan Documents; reasonable Collateral audit fees; and Bank’s reasonable attorneys’ fees and expenses
(whether generated in-house or by outside counsel) incurred in amending, enforcing or defending the Loan Documents (including fees and expenses of appeal), incurred before, during and after an Insolvency Proceeding, whether or not suit is brought.

 “Borrower State” means Delaware, the state under whose laws Borrower is organized. 
 “Borrower’s Books” means all of Borrower’s books and records including: ledgers; records concerning Borrower’s
assets or liabilities, the Collateral, business operations or financial condition; and all computer programs, or tape files, and the equipment, containing such information. 
 “Business Day” means any day that is not a Saturday, Sunday, or other day on which banks in the State of California are
authorized or required to close. 
 “Cash” means unrestricted cash and cash equivalents. 
 “Change in Control” means a transaction in which any “person” or “group” (within the meaning of
Section 13(d) and 14(d)(2) of the Securities Exchange Act of 1934) becomes the “beneficial owner” (as defined in Rule 13d-3 under the Securities Exchange Act of 1934), directly or indirectly, of a sufficient number of shares of all
classes of stock then outstanding of Borrower ordinarily entitled to vote in the election of directors, empowering such “person” or “group” to elect a majority of the Board of Directors of Borrower, who did not have such power
before such transaction. 

 “Chief Executive Office State” means California, where Borrower’s chief
executive office is located. 
 “Closing Date” means the date of this Agreement. 
 “Code” means the California Uniform Commercial Code, as amended or supplemented from time to time. 
 “Collateral” means the property described on Exhibit A attached hereto and all Negotiable Collateral to the extent not
described on Exhibit A, except to the extent any such property (i) is nonassignable by its terms without the consent of the licensor thereof or another party (but only to the extent such prohibition on transfer is enforceable under
applicable law, including, without limitation, Sections 9406 and 9408 of the Code), or (ii) the granting of a security interest therein is contrary to applicable law, provided that upon the cessation of any such restriction or prohibition, such
property shall automatically become part of the Collateral; provided that in no case shall the definition of “Collateral” exclude any Accounts, proceeds of the disposition of any property, or general intangibles consisting of rights to
payment. 
 “Collateral State” means the state or states where the Collateral is located, which is California.

 “Contingent Obligation” means, as applied to any Person, any direct or indirect liability, contingent or
otherwise, of that Person with respect to (i) any indebtedness, lease, dividend, letter of credit or other obligation of another, including, without limitation, any such obligation directly or indirectly guaranteed, endorsed, co-made or
discounted or sold with recourse by that Person, or in respect of which that Person is otherwise directly or indirectly liable; (ii) any obligations with respect to undrawn letters of credit, corporate credit cards, or merchant services issued
for the account of that Person; and (iii) all obligations arising under any interest rate, currency or commodity swap agreement, interest rate cap agreement, interest rate collar agreement, or other agreement or arrangement designated to
protect a Person against fluctuation in interest rates, currency exchange rates or commodity prices; provided, however, that the term “Contingent Obligation” shall not include endorsements for collection or deposit in the ordinary course
of business. The amount of any Contingent Obligation shall be deemed to be an amount equal to the stated or determined amount of the primary obligation in respect of which such Contingent Obligation is made or, if not stated or determinable, the
maximum reasonably anticipated liability in respect thereof as determined by such Person in good faith; provided, however, that such amount shall not in any event exceed the maximum amount of the obligations under the guarantee or other support
arrangement. 
 “Credit Extension” means the Term Loan, or any other extension of credit by Bank to or for the
benefit of Borrower hereunder. 
 “Environmental Laws” means all laws, rules, regulations, orders and the like
issued by any federal state, local foreign or other governmental or quasi-governmental authority or any agency pertaining to the environment or to any hazardous materials or wastes, toxic substances, flammable, explosive or radioactive materials,
asbestos or other similar materials. 
 “Equipment” means all present and future machinery, equipment, tenant
improvements, furniture, fixtures, vehicles, tools, parts and attachments in which Borrower has any interest. 
 “ERISA” means the Employee Retirement Income Security Act of 1974, as amended, and the regulations thereunder. 
 “Event of Default” has the meaning assigned in Article 8. 
 “GAAP” means generally accepted
accounting principles, consistently applied, as in effect from time to time. 
  

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 “Guarantor” means TorreyPines Therapeutics, Inc. 
 “Indebtedness” means (a) all indebtedness for borrowed money or the deferred purchase price of property or services,
including without limitation reimbursement and other obligations with respect to surety bonds and letters of credit, (b) all obligations evidenced by notes, bonds, debentures or similar instruments, (c) all capital lease obligations, and
(d) all Contingent Obligations. 
 “Insolvency Proceeding” means any proceeding commenced by or against any
Person or entity under any provision of the United States Bankruptcy Code, as amended, or under any other bankruptcy or insolvency law, including assignments for the benefit of creditors, formal or informal moratoria, compositions, extension
generally with its creditors, or proceedings seeking reorganization, arrangement, or other relief. 
 “Inventory”
means all present and future inventory in which Borrower has any interest. 
 “Investment” means any beneficial
ownership of (including stock, partnership or limited liability company interest or other securities) any Person, or any loan, advance or capital contribution to any Person. 
 “IRC” means the Internal Revenue Code of 1986, as amended, and the regulations thereunder. 
 “Lien” means any mortgage, lien, deed of trust, charge, pledge, security interest or other encumbrance. 
 “Loan Documents” means, collectively, this Agreement, any note or notes executed by Borrower in connection with this Agreement,
and any other document, instrument or agreement entered into in connection with this Agreement, all as amended or extended from time to time. 
 “Material Adverse Effect” means a material adverse effect on (i) the business operations or condition (financial or otherwise) of Borrower and its Subsidiaries taken as a whole, (ii) the ability of
Borrower to repay the Obligations or otherwise perform its obligations under the Loan Documents, or (iii) Borrower’s interest in, or the value, perfection or priority of Bank’s security interest in the Collateral. 
 “Negotiable Collateral” means all of Borrower’s present and future letters of credit of which it is a beneficiary, drafts,
instruments (including promissory notes), securities, documents of title, and chattel paper, and Borrower’s Books relating to any of the foregoing. 
 “Obligations” means all debt, principal, interest, Bank Expenses and other amounts owed to Bank by Borrower pursuant to this Agreement or any other agreement, whether absolute or contingent, due or to become
due, now existing or hereafter arising, including any interest that accrues after the commencement of an Insolvency Proceeding and including any debt, liability, or obligation owing from Borrower to others that Bank may have obtained by assignment
or otherwise; provided that “Obligations” shall not include any obligations of Borrower under the terms of any warrants provided to Bank in connection with this Agreement. 
 “Periodic Payments” means all installments or similar recurring payments that Borrower may now or hereafter become obligated to
pay to Bank pursuant to the terms and provisions of any instrument, or agreement now or hereafter in existence between Borrower and Bank. 
 “Permitted Indebtedness” means: 
 (a) Indebtedness of Borrower in favor of Bank
arising under this Agreement or any other Loan Document; 
 (b) Indebtedness existing on the Closing Date and disclosed in the
Schedule; 
  

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 (c) Indebtedness not to exceed One Hundred Thousand Dollars ($100,000) in the aggregate
in any fiscal year of Borrower secured by a lien described in clause (c) of the defined term “Permitted Liens;” provided that such Indebtedness does not exceed the lesser of the cost or fair market value of the equipment financed with
such Indebtedness; 
 (d) Subordinated Debt; 
 (e) Indebtedness to trade creditors incurred in the ordinary course of business; 
 (f) Indebtedness arising from the endorsement of instruments in the ordinary course of business; 
 (g) Performance bonds, surety bonds or other indemnities or similar obligations issued in the ordinary course of business; 
 (h) Indebtedness of a Subsidiary to another Subsidiary, Indebtedness of a Subsidiary to Borrower and Indebtedness of Borrower in
Subsidiaries not to exceed One Hundred Thousand Dollars ($100,000) in the aggregate in any fiscal year; 
 (i) Other unsecured
Indebtedness in an amount not to exceed One Hundred Thousand Dollars ($100,000) in the aggregate in any fiscal year; and 
 (j) Extensions, refinancings and renewals of any items of Permitted Indebtedness, provided that the principal amount is not increased or the terms modified to impose more burdensome terms upon Borrower or its Subsidiary, as the case may be.

 “Permitted Investment” means: 
 (a) Investments existing on the Closing Date disclosed in the Schedule; and 
 (b) (i) Marketable direct obligations issued or unconditionally guaranteed by the United States of America or any agency or any State
thereof maturing within one (1) year from the date of acquisition thereof, (ii) commercial paper maturing no more than one (1) year from the date of creation thereof and currently having rating of at least A-2 or P-2 from either
Standard & Poor’s Corporation or Moody’s Investors Service, (iii) Bank’s certificates of deposit maturing no more than one year from the date of investment therein, (iv) Bank’s money market accounts, and
(v) Investments made in accordance with Borrower’s Board of Director’s-approved investment policy, as approved in writing by Bank from time to time; 
 (c) Repurchases of stock from employees, officers or directors of Borrower under the terms of applicable repurchase agreements or stock
purchase plans approved from time to time (i) in an aggregate amount not to exceed One Hundred Thousand Dollars ($100,000) in any fiscal year, provided that no Event of Default has occurred, is continuing or would exist after giving effect to
the repurchases, or (ii) in any amount where the consideration for the repurchase is the cancellation of indebtedness owed by such employees, officers or directors to Borrower regardless of whether an Event of Default exists; 
 (d) Investments accepted in connection with Permitted Transfers or asset sales pursuant to Section 7.1; 
 (e) Investments of Subsidiaries in or to other Subsidiaries or Borrower and Investments by Borrower in Subsidiaries not to exceed One
Hundred Thousand Dollars ($100,000) in the aggregate in any fiscal year; 
 (f) Investments not to exceed One Hundred Thousand
Dollars ($100,000) in the aggregate in any fiscal year consisting of (i) travel advances and employee relocation loans and other employee loans and advances in the ordinary course of business, and (ii) loans to employees, officers or
directors relating to the purchase of equity securities of Borrower or its Subsidiaries pursuant to employee stock purchase plan agreements approved by Borrower’s Board of Directors; 
  

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 (g) Investments (including debt obligations) received in connection with the bankruptcy
or reorganization of customers or suppliers and in settlement of delinquent obligations of, and other disputes with, customers or suppliers arising in the ordinary course of Borrower’s business; 
 (h) Investments consisting of notes receivable of, or prepaid royalties and other credit extensions, to customers and suppliers who are
not Affiliates, in the ordinary course of business; provided that this subparagraph (h) shall not apply to Investments of Borrower in any Subsidiary; 
 (i) Investments consisting of the endorsement of negotiable instruments for deposit or collection in the ordinary course of business; 
 (j) Acquisitions permitted under Section 7.3 hereof; 
 (k) Joint ventures or strategic alliances in the ordinary course of Borrower’s business consisting of the non-exclusive licensing of
technology, the development of technology or the providing of technical support, provided that any cash Investments by Borrower do not exceed One Hundred Thousand Dollars ($100,000) in the aggregate in any fiscal year; and 
 (l) Other Investments not to exceed One Hundred Thousand Dollars ($100,000) in the aggregate in any fiscal year. 
 “Permitted Liens” means the following: 
 (a) Any Liens existing on the Closing Date and disclosed in the Schedule (excluding Liens to be satisfied with the proceeds of the
Advances) or arising under this Agreement or the other Loan Documents; 
 (b) Liens for taxes, fees, assessments or other
governmental charges or levies, either not delinquent or being contested in good faith by appropriate proceedings and for which Borrower maintains adequate reserves; provided that the same have no priority over any of Bank’s security interests;

 (c) Liens not to exceed One Hundred Thousand Dollars ($100,000) in the aggregate in any fiscal year (i) upon or in any
Equipment acquired or held by Borrower or any of its Subsidiaries to secure the purchase price of such Equipment or indebtedness incurred solely for the purpose of financing the acquisition or lease of such Equipment, or (ii) existing on such
Equipment at the time of its acquisition, provided that the Lien is confined solely to the property so acquired and improvements thereon, and the proceeds of such Equipment; 
 (d) Leases or subleases and licenses and sublicenses granted to others in the ordinary course of Borrower’s business that do not
interfere in any material respect with the business of Borrower and its Subsidiaries taken as a whole; 
 (e) Liens in favor
of customs and revenue authorities arising in the ordinary course of Borrower’s business and as a matter of law to secure payments of custom duties in connection with the importation of goods; 
 (f) Liens of materialmen, mechanics, warehousemen, carriers, artisans or other similar Liens arising in the ordinary course of
Borrower’s business or by operation of law, which are not past due or which are being contested in good faith by appropriate proceedings and for which reserves have been established in accordance with GAAP; 
  

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 (g) Easements, reservations, rights-of-way, restrictions, minor defects or irregularities
in title and other similar charges or encumbrances affecting real property not causing a material adverse effect on Borrower’s business or operations; 
 (h) Deposits in the ordinary course of Borrower’s business under worker’s compensation, unemployment insurance, social security and other similar laws, or to secure the performance of bids, tenders or
contracts (other than for the repayment of borrowed money) or to secure indemnity, performance or other similar bonds for the performance of bids, tenders or contracts (other than for the repayment of borrowed money) or to secure statutory
obligations (other than liens arising under ERISA or environmental liens) or surety or appeal bonds, or to secure indemnity, performance or other similar bonds; 
 (i) Liens incurred in connection with the extension, renewal or refinancing of the indebtedness secured by Liens of the type described in
clauses (a) through (h) above, provided that any extension, renewal or replacement Lien shall be limited to the property encumbered by the existing Lien and the principal amount of the indebtedness being extended, renewed or refinanced
does not increase; 
 (j) Liens arising from judgments, decrees or attachments in circumstances not constituting an Event of
Default under Sections 8.5 or 8.9; 
 (k) Liens in favor of other financial institutions arising in connection with
Borrower’s deposit accounts held at such institutions to secure standard fees for deposit services charged by, but not financing made available by such institutions; provided that Bank has a perfected security interest in the amounts held in
such deposit accounts; and 
 (l) Liens securing Subordinated Debt. 
 “Permitted Transfer” means the conveyance, sale, lease, transfer or disposition by Borrower or any Subsidiary of: 
 (a) Inventory in the ordinary course of business; 
 (b) licenses and similar arrangements for the use of the property of Borrower or its Subsidiaries in the ordinary course of business,
including non-exclusive licenses for the use of the intellectual property of Borrower and licenses that could not result in a legal transfer of title of the licensed property but that may be exclusive in respects other than territory and that may be
exclusive as to territory only as to discreet geographical areas outside of the United States; 
 (c) Transfers from any
Subsidiary to Borrower; 
 (d) Surplus, worn-out or obsolete Equipment; 
 (e) Transfers permitted by Section 7.1, Section 7.3, Section 7.6 and Section 7.7 hereof; 
 (f) the intellectual property disclosed in the Schedule; and 
 (g) other assets of Borrower or its Subsidiaries that do not in the aggregate exceed One Hundred Thousand Dollars ($100,000) during any
fiscal year. 
 “Person” means any individual, sole proprietorship, partnership, limited liability company, joint
venture, trust, unincorporated organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or governmental agency. 
 “Prime Rate” means the variable rate of interest, per annum, most recently announced by Bank, as its “prime rate,”
whether or not such announced rate is the lowest rate available from Bank. 
  

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 “Responsible Officer” means each of the Chief Executive Officer, the Chief
Operating Officer, the Chief Financial Officer and the Controller of Borrower. 
 “Schedule” means the schedule of
exceptions attached hereto and approved by Bank. 
 “Shares” means (i) sixty-five percent (65%) of the
issued and outstanding capital stock, membership units or other securities owned or held of record by Borrower in any Subsidiary of Borrower which is not an entity organized under the laws of the United States or any territory thereof, and
(ii) one hundred percent (100%) of the issued and outstanding capital stock, membership units or other securities owned or held of record by Borrower in any Subsidiary of Borrower which is an entity organized under the laws of the United
States or any territory thereof. 
 “SOS Reports” means the official reports from the Secretaries of State of each
Collateral State, Chief Executive Office State and the Borrower State and other applicable federal, state or local government offices identifying all current security interests filed in the Collateral and Liens of record as of the date of such
report. 
 “Subordinated Debt” means any debt incurred by Borrower that is subordinated in writing to the debt owing
by Borrower to Bank on terms reasonably acceptable to Bank (and identified as being such by Borrower and Bank). 
 “Subsidiary” means any corporation, partnership or limited liability company or joint venture in which (i) any general partnership interest or (ii) more than fifty percent (50%) of the stock, limited liability
company interest or joint venture of which by the terms thereof has the ordinary voting power to elect the Board of Directors, managers or trustees of the entity, at the time as of which any determination is being made, is owned by Borrower, either
directly or through an Affiliate. 
 “Term Loan” has the meaning set forth in Section 2.1(b). 
 “Term Loan Maturity Date” means June 11, 2011. 
 1.2 Accounting Terms. Any accounting term not specifically defined herein shall be construed in accordance with GAAP and all
calculations shall be made in accordance with GAAP. The term “financial statements” shall include the accompanying notes and schedules. 
 2. LOAN AND TERMS OF PAYMENT. 
 2.1 Credit Extensions. 
 (a) Promise to Pay. Borrower promises to pay to Bank, in lawful money of the United States of America, the aggregate unpaid
principal amount of all Credit Extensions made by Bank to Borrower, together with interest on the unpaid principal amount of such Credit Extensions at rates in accordance with the terms hereof. 
 (b) Term Loan. 
 (i) Subject to and upon the terms and conditions of this Agreement, on the Closing Date or as soon thereafter as is practical, Bank shall make one term loan to Borrower in an aggregate amount not to exceed Three
Million Six Hundred Thousand Dollars ($3,600,000) (the “Term Loan”), which amount shall be used to refinance existing Indebtedness and for general corporate purposes. 
 (ii) Interest shall accrue from the date the Term Loan is made at the rate specified in Section 2.3(a), and shall be payable monthly
on the second day of each month commencing on the first day of the first month after the Term Loan is made. The Term Loan shall be repaid in thirty (30) equal monthly installments of principal plus accrued but unpaid interest, commencing on
January 11, 2009 and continuing on the same day of each month thereafter through 

  

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the Term Loan Maturity Date, at which time all amounts owing under this Section 2.1(b) shall be immediately due and payable. The Term Loan, once repaid,
may not be reborrowed. Borrower may prepay the Term Loan without penalty or premium. 
 2.2 Intentionally Omitted.

 2.3 Interest Rates, Payments, and Calculations. 
 (a) Interest Rate. Except as set forth in Section 2.3(b), the Term Loan shall bear interest, on the outstanding daily balance
thereof, at a rate equal to one percent (1.00%) above the Prime Rate 
 (b) Late Fee; Default Rate. If any payment
is not made within ten (10) days after the date such payment is due, Borrower shall pay Bank a late fee equal to the lesser of (i) five percent (5%) of the amount of such unpaid amount or (ii) the maximum amount permitted to be
charged under applicable law. All Obligations shall bear interest, from and after the occurrence and during the continuance of an Event of Default, at a rate equal to five (5) percentage points above the interest rate applicable immediately
prior to the occurrence of the Event of Default. 
 (c) Payments. Interest hereunder shall be due and payable on the
ninth calendar day of each month during the term hereof. Bank shall, at its option, charge such interest, all Bank Expenses, and all Periodic Payments against any of Borrower’s deposit accounts, in which case those amounts shall thereafter
accrue interest at the rate then applicable hereunder. Any interest not paid when due shall be compounded by becoming a part of the Obligations, and such interest shall thereafter accrue interest at the rate then applicable hereunder. 
 (d) Computation. In the event the Prime Rate is changed from time to time hereafter, the applicable rate of interest hereunder
shall be increased or decreased, effective as of the day the Prime Rate is changed, by an amount equal to such change in the Prime Rate. All interest chargeable under the Loan Documents shall be computed on the basis of a three hundred sixty
(360) day year for the actual number of days elapsed. 
 2.4 Crediting Payments. Prior to the occurrence and
continuance of an Event of Default, Bank shall credit a wire transfer of funds, check or other item of payment to such deposit account or Obligation as Borrower specifies. After the occurrence and continuance of an Event of Default, Bank shall have
the right, in its sole discretion, to immediately apply any wire transfer of funds, check, or other item of payment to conditionally reduce Obligations, but such applications of funds shall not be considered a payment on account unless such payment
is of immediately available federal funds or unless and until such check or other item of payment is honored when presented for payment. Notwithstanding anything to the contrary contained herein, any wire transfer or payment received by Bank after
12:00 noon Pacific time shall be deemed to have been received by Bank as of the opening of business on the immediately following Business Day. Whenever any payment to Bank under the Loan Documents would otherwise be due (except by reason of
acceleration) on a date that is not a Business Day, such payment shall instead be due on the next Business Day, and additional fees or interest, as the case may be, shall accrue and be payable for the period of such extension. 
 2.5 Fees. Borrower shall pay to Bank the following: 
 (a) Facility Fee. On the Closing Date, a fee equal to $27,000, which shall be nonrefundable; and 
 (b) Bank Expenses. On the Closing Date, all Bank Expenses incurred through the Closing Date, and, after the Closing Date, all Bank
Expenses as and when they become due. 
 2.6 Term. This Agreement shall become effective on the Closing Date and,
subject to Section 13.7, shall continue in full force and effect for so long as any Obligations remain outstanding or Bank has any obligation to make Credit Extensions under this Agreement. Notwithstanding the foregoing, Bank shall have the
right to terminate its obligation to make Credit Extensions under this Agreement immediately and without notice upon the occurrence and during the continuance of an Event of Default. 
  

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 3. CONDITIONS OF LOANS. 
 3.1 Conditions Precedent to Initial Credit Extension. The obligation of Bank to make the initial Credit Extension is subject to the
condition precedent that Bank shall have received, in form and substance satisfactory to Bank, the following: 
 (a) this
Agreement; 
 (b) an officer’s certificate of Borrower with respect to incumbency and resolutions authorizing the
execution and delivery of this Agreement; 
 (c) UCC National Form Financing Statement naming each of Borrower and Guarantor
as debtor; 
 (a) an unconditional guaranty and third party security agreement from Guarantor; 
 (d) an officer’s certificate of Guarantor with respect to incumbency and resolutions authorizing the execution and delivery of any
Loan Documents to which Guarantor is a party; 
 (e) a warrant to purchase stock; 
 (f) the certificate(s) for the Shares, together with Assignment(s) Separate from Certificate, duly executed by in blank; 
 (g) current SOS Reports indicating that except for Permitted Liens, there are no other security interests or Liens of record in the
Collateral; 
 (h) agreement to furnish insurance; 
 (i) payment of the fees and Bank Expenses then due specified in Section 2.5 hereof; 
 (j) current financial statements, including audited statements for Borrower’s most recently ended fiscal year, together with an
unqualified opinion, company prepared consolidated and consolidating balance sheets and income statements for the most recently ended month in accordance with Section 6.2, and such other updated financial information as Bank may reasonably
request; 
 (k) current Compliance Certificate in accordance with Section 6.2; and 
 (l) such other documents or certificates, and completion of such other matters, as Bank may reasonably deem necessary or appropriate.

 3.2 Conditions Precedent to all Credit Extensions. The obligation of Bank to make each Credit Extension, including
the initial Credit Extension, is further subject to the following conditions: 
 (a) timely receipt by Bank of the
Payment/Advance Form as provided in Section 2.1; and 
 (b) the representations and warranties contained in
Section 5 shall be true and correct in all material respects on and as of the date of such Payment/Advance Form and on the effective date of each Credit Extension as though made at and as of each such date, and no Event of Default shall have
occurred and be continuing, or would exist after giving effect to such Credit Extension (provided, however, that those representations and warranties expressly referring to another date shall be true, correct and complete in all material respects as
of such date). The making of each Credit Extension shall be deemed to be a representation and warranty by Borrower on the date of such Credit Extension as to the accuracy of the facts referred to in this Section 3.2. 
  

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 4. CREATION OF SECURITY INTEREST. 
 4.1 Grant of Security Interest. Borrower grants and pledges to Bank a continuing security interest in the Collateral to secure
prompt repayment of any and all Obligations and in order to secure prompt performance by Borrower of each of its covenants and duties under the Loan Documents. Except as set forth in the Schedule and except for Permitted Liens, such security
interest constitutes a valid, first priority security interest in the presently existing Collateral, and, except for Permitted Liens, will constitute a valid, first priority security interest in later-acquired Collateral. Borrower also hereby agrees
to not sell, transfer, assign, mortgage, pledge, lease, grant a security interest in, or encumber any of its intellectual property, other than in connection with a Permitted Transfer. Notwithstanding any termination, Bank’s Lien on the
Collateral shall remain in effect for so long as any Obligations are outstanding. 
 4.2 Perfection of Security
Interest. Borrower authorizes Bank to file at any time financing statements, continuation statements, and amendments thereto that (i) either specifically describe the Collateral or describe the Collateral as all assets of Borrower of the
kind pledged hereunder, and (ii) contain any other information required by the Code for the sufficiency of filing office acceptance of any financing statement, continuation statement, or amendment, including whether Borrower is an organization,
the type of organization and any organizational identification number issued to Borrower, if applicable. Any such financing statements may be signed by Bank on behalf of Borrower, as provided in the Code, and may be filed at any time in any
jurisdiction whether or not Revised Article 9 of the Code is then in effect in that jurisdiction. Borrower shall from time to time endorse and deliver to Bank, at the reasonable request of Bank, all Negotiable Collateral and other documents
that Bank may reasonably request, in form reasonably satisfactory to Bank, to perfect and continue perfected Bank’s security interests in the Collateral and in order to fully consummate all of the transactions contemplated under the Loan
Documents. Borrower shall have possession of the Collateral, except where expressly otherwise provided in this Agreement or where Bank chooses in its reasonable business discretion to perfect its security interest by possession in addition to the
filing of a financing statement. Where Collateral is in possession of a third party bailee, Borrower shall take such steps as Bank reasonably requests for Bank to (i) obtain an acknowledgment, in form and substance reasonably satisfactory to
Bank, of the bailee that the bailee holds such Collateral for the benefit of Bank, (ii) obtain “control” of any Collateral consisting of investment property, deposit accounts, letter-of-credit rights or electronic chattel paper (as
such items and the term “control” are defined in Revised Article 9 of the Code) by causing the securities intermediary or depositary institution or issuing bank to execute a control agreement in form and substance reasonably
satisfactory to Bank. Borrower will not create any chattel paper without placing a legend on the chattel paper acceptable to Bank indicating that Bank has a security interest in the chattel paper. Borrower from time to time may deposit with Bank
specific cash collateral to secure specific Obligations; Borrower authorizes Bank to hold such specific balances in pledge and to decline to honor any drafts thereon or any request by Borrower or any other Person to pay or otherwise transfer any
part of such balances for so long as the specific Obligations are outstanding. 
 4.3 Right to Inspect. Bank (through
any of its officers, employees, or agents) shall have the right, upon reasonable prior written notice, from time to time during Borrower’s usual business hours but no more than once a year (unless an Event of Default has occurred and is
continuing), to inspect Borrower’s Books and to make copies thereof and to check, test, and appraise the Collateral in order to verify Borrower’s financial condition or the amount, condition of, or any other matter relating to, the
Collateral. 
 4.4 Pledge of Collateral. Borrower hereby pledges, assigns and grants to Bank a security interest in all
the Shares, together with all proceeds and substitutions thereof, all cash, stock and other moneys and property paid thereon, all rights to subscribe for securities declared or granted in connection therewith, and all other cash and noncash proceeds
of the foregoing, as security for the performance of the Obligations. On the Closing Date, the certificate or certificates for the Shares will be delivered to Bank, accompanied by an instrument of assignment duly executed in blank by Borrower. To
the extent required by the terms and conditions governing the Shares, Borrower shall cause the books of each entity whose Shares are part of the Collateral and any transfer agent to reflect the pledge of the Shares. Upon the occurrence of an Event
of Default hereunder, Bank may effect the transfer of any securities included in the Collateral (including but not limited to the Shares) into the name of Bank and cause 

  

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new certificates representing such securities to be issued in the name of Bank or its transferee. Borrower will execute and deliver such documents, and take
or cause to be taken such actions, as Bank may reasonably request to perfect or continue the perfection of Bank’s security interest in the Shares. Unless an Event of Default shall have occurred and be continuing, Borrower shall be entitled to
exercise any voting rights with respect to the Shares and to give consents, waivers and ratifications in respect thereof; provided that no vote shall be cast or consent, waiver or ratification given or action taken which would be inconsistent with
any of the terms of this Agreement or which would constitute or create any violation of any of such terms. All such rights to vote and give consents, waivers and ratifications shall terminate upon the occurrence and continuance of an Event of
Default. 
 4.5 Cash Collateral. In the event Borrower fails to comply with Section 6.7 hereof, and without any
further action on the part of Borrower or Bank and without limitation on Bank’s other rights and remedies, as additional security for all present and future indebtedness and other Obligations of Borrower to Bank under this Agreement or any
other agreement, Borrower shall be deemed to grant to Bank a continuing security interest in all accounts maintained with, and all certificates of deposit issued by, Bank from time to time, which shall at all times equal at least the amount of the
then outstanding Obligations, together with all proceeds and substitutions thereof, all interest and dividends paid thereon, and all other cash and noncash proceeds of the foregoing (all hereinafter called the “Cash Collateral”). Borrower
shall enter into such control or other agreements as Bank reasonably requests in order to perfect or ensure the priority of Bank’s security interest in the Cash Collateral. 
 4.6 Termination of Financing Statement. Upon indefeasible payment in full and satisfaction by Borrower of all of the Obligations,
Bank shall, upon written request from (and at the expense of) Borrower, promptly file a termination statement with respect to the Collateral, and provide written evidence of the same to Borrower. 
 5. REPRESENTATIONS AND WARRANTIES. 
 Borrower represents and warrants as follows: 
 5.1 Due Organization and Qualification.
Borrower and each Subsidiary is duly existing under the laws of the state in which it is organized and qualified and licensed to do business in any state in which the conduct of its business or its ownership of property requires that it be so
qualified or licensed, except where the failure to do so could not reasonably be expected to cause a Material Adverse Effect. 
 5.2 Due Authorization; No Conflict. The execution, delivery, and performance of the Loan Documents are within Borrower’s powers, have been duly authorized, and are not in conflict with nor constitute a breach of any provision
contained in Borrower’s Certificate of Incorporation or Bylaws, nor will they constitute an event of default under any material agreement by which Borrower is bound. Borrower is not in default under any agreement by which it is bound, except to
the extent such default could not reasonably be expected to cause a Material Adverse Effect. 
 5.3 Collateral.
Borrower has rights in or the power to transfer the Collateral, and its title to the Collateral is free and clear of Liens, adverse claims, and restrictions on transfer or pledge except for Permitted Liens. Other than mobile items of personal
property, such as laptop computers, having an aggregate book value not in excess of One Hundred Thousand Dollars ($100,000), all Collateral is located solely in the Collateral States. All Inventory is in all material respects of good and
merchantable quality, free from all material defects, except for Inventory for which adequate reserves have been made. Except as set forth in the Schedule and except as may be permitted pursuant to Section 7.10, none of the Collateral is
maintained or invested with a Person other than Bank or Bank’s Affiliates. 
 5.4 Intellectual Property. Borrower
is the sole owner of its patents, trademarks, copyrights and other intellectual property, except for non-exclusive licenses granted by Borrower to its customers in the ordinary course of business. To the best of Borrower’s knowledge, each of
Borrower’s patents, trademarks and copyrights is valid and enforceable, and no part of its intellectual property has been judged invalid or unenforceable, in whole or in part, and no claim has been made to Borrower that any part of its
intellectual property violates the rights of any third party except to the extent such invalidity, unenforceability or claim could not reasonably be expected to cause a Material Adverse Effect. 
  

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 5.5 Name; Location of Chief Executive Office. Except as disclosed in the Schedule,
Borrower has not done business under any name other than that specified on the signature page hereof, and its exact legal name is as set forth in the first paragraph of this Agreement. The chief executive office of Borrower is located in the Chief
Executive Office State at the address indicated in Section 10 hereof. 
 5.6 Litigation. Except as set forth in
the Schedule, there are no actions or proceedings pending by or against Borrower or any Subsidiary before any court or administrative agency in which a likely adverse decision could reasonably be expected to have a Material Adverse Effect.

 5.7 No Material Adverse Change in Financial Statements. All consolidated and consolidating financial statements
related to Borrower and any Subsidiary that are delivered by Borrower to Bank fairly present in all material respects Borrower’s consolidated and consolidating financial condition as of the date thereof and Borrower’s consolidated and
consolidating results of operations for the period then ended. There has not been a material adverse change in the consolidated or in the consolidating financial condition of Borrower since the date of the most recent of such financial statements
submitted to Bank. 
 5.8 Solvency, Payment of Debts. Borrower is able to pay its debts (including trade debts) as they
mature; the fair saleable value of Borrower’s assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities; and Borrower is not left with unreasonably small capital after the transactions contemplated by this
Agreement. 
 5.9 Compliance with Laws and Regulations. Borrower and each Subsidiary have met the minimum funding
requirements of ERISA with respect to any employee benefit plans subject to ERISA. No event has occurred resulting from Borrower’s failure to comply with ERISA that is reasonably likely to result in Borrower’s incurring any liability that
could reasonably be expected to have a Material Adverse Effect. Borrower is not an “investment company” or a company “controlled” by an “investment company” within the meaning of the Investment Company Act of 1940.
Borrower is not engaged principally, or as one of the important activities, in the business of extending credit for the purpose of purchasing or carrying margin stock (within the meaning of Regulations T and U of the Board of Governors of the
Federal Reserve System). Borrower has complied in all material respects with all applicable provisions of the Federal Fair Labor Standards Act. Borrower is in compliance with all applicable environmental laws, regulations and ordinances except where
the failure to comply is not reasonably likely to have a Material Adverse Effect. Borrower has not violated any statutes, laws, ordinances or rules applicable to it, the violation of which could reasonably be expected to have a Material Adverse
Effect. Borrower and each Subsidiary have filed or caused to be filed all tax returns required to be filed, and have paid, or have made adequate provision for the payment of, all taxes reflected therein except those being contested in good faith
with adequate reserves under GAAP or where the failure to file such returns or pay such taxes could not reasonably be expected to have a Material Adverse Effect. 
 5.10 Subsidiaries. Borrower does not own any stock, partnership interest or other equity securities of any Person, except for
Permitted Investments. 
 5.11 Government Consents. Borrower and each Subsidiary have obtained all consents, approvals
and authorizations of, made all declarations or filings with, and given all notices to, all governmental authorities that are necessary for the continued operation of Borrower’s business as currently conducted, except where the failure to do so
could not reasonably be expected to cause a Material Adverse Effect. 
 5.12 Inbound Licenses. Except as disclosed on
the Schedule, Borrower is not a party to, nor is bound by, any material license or other similar material agreement that prohibits or otherwise restricts Borrower from granting a security interest in Borrower’s interest in such license or
agreement or any other property. 
 5.13 Shares. Borrower has full power and authority to create a first lien on the
Shares and no disability or contractual obligation exists that would prohibit Borrower from pledging the Shares pursuant to this Agreement. To Borrower’s knowledge, there are no subscriptions, warrants, rights of first refusal or other
restrictions on transfer relative to, or options exercisable with respect to the Shares. The Shares have been and will be duly authorized and validly issued, and are fully paid and non-assessable. To Borrower’s knowledge, the Shares are not the
subject of any present or threatened suit, action, arbitration, administrative or other proceeding, and Borrower knows of no reasonable grounds for the institution of any such proceedings. 
  

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 5.14 Full Disclosure. No representation, warranty or other statement made by
Borrower in any certificate or written statement furnished to Bank taken together with all such certificates and written statements furnished to Bank contains any untrue statement of a material fact or omits to state a material fact necessary in
order to make the statements contained in such certificates or statements not misleading in light of the circumstances under which they were made, it being recognized by Bank that the projections and forecasts provided by Borrower in good faith and
based upon reasonable assumptions are not to be viewed as facts and that actual results during the period or periods covered by any such projections and forecasts may differ from the projected or forecasted results. 
 6. AFFIRMATIVE COVENANTS. 
 Borrower covenants and agrees that, until payment in full of all outstanding Obligations, and for so long as Bank may have any commitment to make a Credit Extension hereunder, Borrower shall do all of the following: 
 6.1 Good Standing and Government Compliance. Borrower shall maintain its and each of its Subsidiaries’ corporate existence and
good standing in the Borrower State, shall maintain qualification and good standing in each other jurisdiction in which the failure to maintain or so qualify could reasonably be expected to have a Material Adverse Effect, and shall furnish to Bank
the organizational identification number issued to Borrower by the authorities of the state in which Borrower is organized, if applicable. Borrower shall meet, and shall cause each Subsidiary to meet, the minimum funding requirements of ERISA with
respect to any employee benefit plans subject to ERISA, except where the failure to meet such requirements could not reasonably be expected to have a Material Adverse Effect. Borrower shall comply in all material respects with all applicable
Environmental Laws, and maintain all material permits, licenses and approvals required thereunder where the failure to do so could reasonably be expected to have a Material Adverse Effect. Borrower shall comply, and shall cause each Subsidiary to
comply, with all statutes, laws, ordinances and government rules and regulations to which it is subject, and shall maintain, and shall cause each of its Subsidiaries to maintain, in force all licenses, approvals and agreements, the loss of which or
failure to comply with which could reasonably be expected to have a Material Adverse Effect. 
 6.2 Financial Statements,
Reports, Certificates. Borrower shall deliver the following to Bank: (i) if applicable, copies of all statements, reports and notices sent or made available generally by Borrower to its security holders or to any holders of Subordinated
Debt and all reports on Forms 10-K and 10-Q filed with the Securities and Exchange Commission; (ii) promptly upon receipt of notice thereof, a report of any legal actions pending or threatened against Borrower or any Subsidiary that could
reasonably be expected to result in damages or costs to Borrower or any Subsidiary of Two Hundred Fifty Thousand Dollars ($250,000) or more; (iii) promptly upon receipt, each management letter prepared by Borrower’s independent certified
public accounting firm regarding Borrower’s management control systems; and (iv) such budgets, sales projections, operating plans or other financial information as Bank may reasonably request from time to time. 
 (a) Within thirty (30) days after the last day of each month, Borrower shall deliver to Bank a Compliance Certificate certified as of
the last day of the applicable month and signed by a Responsible Officer in substantially the form of Exhibit C hereto. 
 (b) As soon as possible and in any event within three (3) calendar days after becoming aware of the occurrence or existence of an Event of Default hereunder, a written statement of a Responsible Officer setting forth details of the
Event of Default, and the action which Borrower has taken or proposes to take with respect thereto. 
 (c) Bank shall have a
right from time to time hereafter to audit Borrower’s Accounts and appraise Collateral at Borrower’s reasonable expense; provided that such audits will be conducted no more often than every twelve (12) months unless an Event of
Default has occurred and is continuing; provided further that such audits shall be conducted during Borrower’s normal business hours. 
  

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 Borrower may deliver to Bank on an electronic basis any certificates, reports or information required
pursuant to this Section 6.2, and Bank shall be entitled to rely on the information contained in the electronic files; provided that Bank in good faith believes that the files were delivered by a Responsible Officer. If Borrower delivers this
information electronically, it shall also deliver to Bank by U.S. Mail, reputable overnight courier service, hand delivery, facsimile or .pdf file within five (5) Business Days of submission of the unsigned electronic copy the intellectual
property report and the Compliance Certificate, each bearing the physical signature of the Responsible Officer. 
 6.3
Inventory; Returns. Borrower shall keep all Inventory in good and merchantable condition, free from all material defects except for Inventory for which adequate reserves have been made. Returns and allowances, if any, as between Borrower and
its account debtors shall be on the same basis and in accordance with the usual customary practices of Borrower, as they exist on the Closing Date. Borrower shall promptly notify Bank of all returns and recoveries and of all disputes and claims
involving more than Two Hundred Fifty Thousand Dollars ($250,000). 
 6.4 Taxes. Borrower shall make, and cause each
Subsidiary to make, due and timely payment or deposit of all material federal, state, and local taxes, assessments, or contributions required of it by law, other than such failures that could reasonably be expected to cause a Material Adverse
Effect, including, but not limited to, those laws concerning income taxes, F.I.C.A., F.U.T.A. and state disability, and will execute and deliver to Bank, promptly on demand, proof reasonably satisfactory to Bank indicating that Borrower or a
Subsidiary has made such payments or deposits and any appropriate certificates attesting to the payment or deposit thereof; provided that Borrower or a Subsidiary need not make any payment if the amount or validity of such payment is contested in
good faith by appropriate proceedings and is reserved against (to the extent required by GAAP) by Borrower. 
 6.5
Insurance. 
 (a) Borrower, at its expense, shall keep the Collateral insured against loss or damage by fire, theft,
explosion, sprinklers, and all other hazards and risks, and in such amounts, as ordinarily insured against by other owners in similar businesses conducted in the locations where Borrower’s business is conducted on the date hereof. Borrower
shall also maintain liability and other insurance in amounts and of a type that are customary to businesses similar to Borrower’s. 
 (b) All such policies of insurance shall be in such form, with such companies, and in such amounts as are reasonably satisfactory to Bank. All policies of property insurance shall contain a lender’s loss payable
endorsement, in a form reasonably satisfactory to Bank, showing Bank as an additional loss payee, and all liability insurance policies shall show the Bank as an additional insured and shall specify that the insurer must give at least 20 days notice
to Bank before canceling its policy for any reason. Upon Bank’s reasonable request, Borrower shall deliver to Bank certified copies of the policies of insurance and evidence of all premium payments. If no Event of Default has occurred and is
continuing, proceeds payable under any casualty policy will, at Borrower’s option, be payable to Borrower to replace the property subject to the claim; provided that any such replacement property shall be deemed Collateral in which Bank has
been granted a first priority security interest. If an Event of Default has occurred and is continuing, all proceeds payable under any such policy shall, at Bank’s option, be payable to Bank to be applied on account of the Obligations.

 6.6 Accounts. Borrower shall maintain all its depository, operating and investment accounts with Bank.
Notwithstanding the foregoing, Borrower shall be permitted to maintain no more than Three Million Five Hundred Thousand Dollars ($3,500,000) (U.S.) in an account in Belgium. 
 6.7 Financial Covenant. Borrower shall at all times maintain a balance of Cash at Bank of not less Five Million Four Hundred
Thousand Dollars ($5,400,000). 
 6.8 Consent of Inbound Licensors. Prior to entering into or becoming bound by any
inbound license, the failure, breach or termination of which could reasonably be expected to have a Material Adverse Effect, Borrower shall provide written notice to Bank of the material terms of such license with a description of its likely impact
on Borrower’s business or financial condition. 
  

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 6.9 Creation/Acquisition of Subsidiaries. In the event Borrower or any Subsidiary
creates or acquires any Subsidiary, Borrower and such Subsidiary shall promptly notify Bank of the creation or acquisition of such new Subsidiary and take all such action as may be reasonably required by Bank to cause such Subsidiary to guarantee
the Obligations of Borrower under the Loan Documents and grant a continuing pledge and security interest in and to the collateral of such Subsidiary (substantially as described on Exhibit A hereto), and Borrower shall grant and pledge to Bank a
perfected security interest in the stock, units or other evidence of ownership of such Subsidiary. 
 6.10 Further
Assurances. At any time and from time to time Borrower shall execute and deliver such further instruments and take such further action as may reasonably be requested by Bank to effect the purposes of this Agreement. 
 7. NEGATIVE COVENANTS. 
 Borrower covenants and agrees that, so long as any credit hereunder shall be available and until the outstanding Obligations are paid in full or for so long as Bank may have any commitment to make any Credit Extensions, Borrower will not do
any of the following without Bank’s prior written consent, which shall not be unreasonably withheld: 
 7.1
Dispositions. Convey, sell, lease, license, transfer or otherwise dispose of (collectively, to “Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of its business or property, including its intellectual
property, or move cash balances on deposit with Bank to accounts opened at another financial institution, other than Permitted Transfers. 
 7.2 Change in Name, Location, Executive Office, or Executive Management; Change in Business; Change in Fiscal Year; Change in Control. Change its name or the Borrower State or relocate its chief executive
office without thirty (30) days prior written notification to Bank; replace its chief executive officer or chief financial officer without thirty (30) days prior written notification to Bank (unless any such officer voluntarily resigns or
cause exists for (and results in) immediate termination, in which case Borrower shall promptly notify Bank upon receipt of such resignation or upon such termination); engage in any business, or permit any of its Subsidiaries to engage in any
business, other than or reasonably related or incidental to the businesses currently engaged in by Borrower or any Subsidiary; change its fiscal year end; suffer or permit a Change in Control. 
 7.3 Mergers or Acquisitions. Merge or consolidate, or permit any of its Subsidiaries to merge or consolidate, with or into any
other business organization (other than mergers or consolidations of a Subsidiary into another Subsidiary or into Borrower), or acquire, or permit any of its Subsidiaries to acquire, all or substantially all of the capital stock or property of
another Person except where (i) such transactions do not in the aggregate exceed One Hundred Thousand Dollars ($100,000) during any fiscal year, (ii) no Event of Default has occurred, is continuing or would exist after giving effect to
such transactions, (iii) such transactions do not result in a Change in Control, and (iv) Borrower is the surviving entity. 
 7.4 Indebtedness. Create, incur, assume, guarantee or be or remain liable with respect to any Indebtedness, or permit any Subsidiary so to do, other than Permitted Indebtedness, or prepay any Indebtedness or
take any actions which impose on Borrower an obligation to prepay any Indebtedness, except Indebtedness to Bank or the refinancing of Permitted Indebtedness (as permitted by and in accordance with the definition of “Permitted
Indebtedness”). 
 7.5 Encumbrances. Create, incur, assume or allow any Lien with respect to any of its property,
or assign or otherwise convey any right to receive income, including the sale of any Accounts, or permit any of its Subsidiaries so to do, except for Permitted Liens. Agree with any Person other than Bank not to grant a security interest in, or
otherwise encumber, any of its, or covenant to any other Person that Borrower in the future will refrain from creating, incurring, assuming or allowing any Lien with respect to any of Borrower’s property, or permit any Subsidiary to do so.

  

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 7.6 Distributions. Pay any dividends or make any other distribution or payment on
account of or in redemption, retirement or purchase of any capital stock, except that Borrower may (i) repurchase the stock of employees, officers and directors pursuant to stock repurchase agreements or stock purchase plans as long as an Event
of Default does not exist prior to such repurchase or would not exist after giving effect to such repurchase, (ii) repurchase the stock of employees, officers and directors pursuant to stock repurchase agreements or stock purchase plans by the
cancellation of indebtedness owed by such former employees to Borrower regardless of whether an Event of Default exists, (iii) pay dividends in capital stock, (iv) convert any of its convertible securities (including warrants) into other
securities pursuant to the terms of such convertible securities and (v) distribute securities to employees, officers or directors upon the exercise of their options. 
 7.7 Investments. Except as permitted under Section 7.3 and except for Permitted Investments, directly or indirectly acquire or
own, or make any Investment in or to any Person, or permit any of its Subsidiaries so to do, other than Permitted Investments, or maintain or invest any of its property with a Person other than Bank or Bank’s Affiliates or permit any Subsidiary
to do so unless such Person has entered into a control agreement with Bank, in form and substance reasonably satisfactory to Bank, or suffer or permit any Subsidiary to be a party to, or be bound by, an agreement that restricts such Subsidiary from
paying dividends or otherwise distributing property to Borrower. 
 7.8 Transactions with Affiliates. Directly or
indirectly enter into or permit to exist any material transaction with any Affiliate of Borrower except for transactions that are in the ordinary course of Borrower’s business, upon fair and reasonable terms that are no less favorable to
Borrower than would be obtained in an arm’s length transaction with a non-affiliated Person or as otherwise expressly permitted hereunder; provided that the foregoing restriction shall not apply to (a) reasonable and customary fees
paid to members of the Board of Directors of Borrower and its Subsidiaries, (b) the raising of new equity for Borrower from Borrower’s investors as of the Closing Date, with respect to the pricing of such equity, or (c) employment
arrangements with executive officers approved by Borrower’s Board of Directors from time to time. 
 7.9 Subordinated
Debt. Make any payment in respect of any Subordinated Debt, or permit any of its Subsidiaries to make any such payment, except in compliance with the terms of such Subordinated Debt, or amend any provision affecting Bank’s rights contained
in any documentation relating to the Subordinated Debt without Bank’s prior written consent, which consent shall not be unreasonably withheld. 
 7.10 Inventory and Equipment. Store the Inventory or the Equipment with a bailee, warehouseman, or similar third party unless the third party has been notified of Bank’s security interest and Bank
(a) has received an acknowledgment from the third party that it is holding or will hold the Inventory or Equipment for Bank’s benefit or (b) is in possession of the warehouse receipt, where negotiable, covering such Inventory or
Equipment. Except for Permitted Transfers, mobile items of personal property, such as laptop computers, having an aggregate book value not in excess of One Hundred Thousand Dollars ($100,000), Inventory sold in the ordinary course of business and
except for such other locations as Bank may approve in writing, Borrower shall keep the Inventory and Equipment only at the location set forth in Section 10 and such other locations of which Borrower gives Bank prior written notice and as to
which Bank files a financing statement, or takes other action, where needed to perfect its security interest. 
 7.11 No
Investment Company; Margin Regulation. Become or be controlled by an “investment company,” within the meaning of the Investment Company Act of 1940, or become principally engaged in, or undertake as one of its important activities, the
business of extending credit for the purpose of purchasing or carrying margin stock, or use the proceeds of any Credit Extension for such purpose. 
 8. EVENTS OF DEFAULT. 
 Any one or more of the following events shall constitute an Event of Default by
Borrower under this Agreement: 
 8.1 Payment Default. If Borrower fails to pay any of the Obligations when due;

  

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 8.2 Covenant Default. 
 (a) If Borrower fails to perform any obligation under Section 6.2 or 6.4 through 6.7 or violates any of the covenants contained in
Article 7 of this Agreement; or 
 (b) If Borrower fails or neglects to perform or observe any other material term,
provision, condition, covenant contained in this Agreement, in any of the Loan Documents, or in any other present or future agreement between Borrower and Bank and as to any default under such other term, provision, condition or covenant that can be
cured, has failed to cure such default within ten (10) days after Borrower receives notice thereof or any officer of Borrower becomes aware thereof; provided, however, that if the default cannot by its nature be cured within the ten
(10) day period or cannot after diligent attempts by Borrower be cured within such ten (10) day period, and such default is likely to be cured within a reasonable time, then Borrower shall have an additional reasonable period (which shall
not in any case exceed thirty (30) days) to attempt to cure such default, and within such reasonable time period the failure to have cured such default shall not be deemed an Event of Default but no Credit Extensions will be made; 

8.3 Defective Perfection. If Bank shall receive at any time following the Closing Date an SOS Report indicating that except for
Permitted Liens, Bank’s security interest in the Collateral is not prior to all other security interests or Liens of record reflected in such SOS Report; 
 8.4 Material Adverse Effect. If there occurs any circumstance or circumstances that could have a Material Adverse Effect;

 8.5 Attachment. If any material portion of Borrower’s assets is attached, seized, subjected to a writ or
distress warrant, or is levied upon, or comes into the possession of any trustee, receiver or person acting in a similar capacity and such attachment, seizure, writ or distress warrant or levy has not been removed, discharged or rescinded within ten
(10) days, or if Borrower is enjoined, restrained, or in any way prevented by court order from continuing to conduct all or any material part of its business affairs, or if a judgment or other claim becomes a lien or encumbrance upon any
material portion of Borrower’s assets, or if a notice of lien, levy, or assessment is filed of record with respect to any material portion of Borrower’s assets by the United States Government, or any department, agency, or instrumentality
thereof, or by any state, county, municipal, or governmental agency, and the same is not paid within ten (10) days after Borrower receives notice thereof, provided that none of the foregoing shall constitute an Event of Default where such
action or event is stayed or an adequate bond has been posted pending a good faith contest by Borrower (provided that no Credit Extensions will be made during such cure period); 
 8.6 Insolvency. If Borrower becomes insolvent, or if an Insolvency Proceeding is commenced by Borrower, or if an Insolvency
Proceeding is commenced against Borrower and is not dismissed or stayed within thirty (30) days (provided that no Credit Extensions will be made prior to the dismissal of such Insolvency Proceeding); 
 8.7 Other Agreements. If there is a default or other failure to perform in any agreement to which Borrower is a party with a third
party or parties resulting in a right by such third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in an amount in excess of Two Hundred Fifty Thousand Dollars ($250,000) or that could reasonably be
expected to have a Material Adverse Effect; 
 8.8 Subordinated Debt. If Borrower makes any payment on account of
Subordinated Debt, except to the extent such payment is allowed under any subordination agreement entered into with Bank; 
 8.9 Judgments. If a judgment or judgments for the payment of money in an amount, individually or in the aggregate, of at least Two Hundred Fifty Thousand Dollars ($250,000) shall be rendered against Borrower and shall remain
unsatisfied and unstayed for a period of ten (10) days (provided that no Credit Extensions will be made prior to the satisfaction or stay of such judgment); or 
  

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 8.10 Misrepresentations. If any material misrepresentation or material
misstatement exists now or hereafter in any warranty or representation set forth herein or in any certificate delivered to Bank by any Responsible Officer pursuant to this Agreement or to induce Bank to enter into this Agreement or any other Loan
Document. 
 8.11 Guaranty. If any guaranty of all or a portion of the Obligations (a “Guaranty”) ceases for
any reason to be in full force and effect, or any guarantor fails to perform any obligation under any Guaranty or a security agreement securing any Guaranty (collectively, the “Guaranty Documents”), or any event of default occurs under any
Guaranty Document or any guarantor revokes or purports to revoke a Guaranty, or any material misrepresentation or material misstatement exists now or hereafter in any warranty or representation set forth in any Guaranty Document or in any
certificate delivered to Bank in connection with any Guaranty Document, or if any of the circumstances described in Sections 8.3 through 8.9 occur with respect to any guarantor. 
 9. BANK’S RIGHTS AND REMEDIES. 
 9.1 Rights and Remedies. Upon the occurrence and during the continuance of an Event of Default, Bank may, at its election, without notice of its election and without demand, do any one or more of the following,
all of which are authorized by Borrower: 
 (a) Declare all Obligations, whether evidenced by this Agreement, by any of the
other Loan Documents, or otherwise, immediately due and payable (provided that upon the occurrence of an Event of Default described in Section 8.6, all Obligations shall become immediately due and payable without any action by Bank);

 (b) Demand that Borrower (i) deposit cash with Bank in an amount equal to the amount of any Letters of Credit
remaining undrawn, as collateral security for the repayment of any future drawings under such Letters of Credit, and (ii) pay in advance all Letter of Credit fees scheduled to be paid or payable over the remaining term of the Letters of Credit,
and Borrower shall promptly deposit and pay such amounts; 
 (c) Cease advancing money or extending credit to or for the
benefit of Borrower under this Agreement or under any other agreement between Borrower and Bank; 
 (d) Settle or adjust
disputes and claims directly with account debtors for amounts, upon terms and in whatever order that Bank reasonably considers advisable; 
 (e) Make such payments and do such acts as Bank considers necessary or reasonable to protect its security interest in the Collateral. Borrower agrees to assemble the Collateral if Bank so requires, and to make the
Collateral available to Bank as Bank may reasonably designate. Borrower authorizes Bank to enter the premises where the Collateral is located, to take and maintain possession of the Collateral, or any part of it, and to pay, purchase, contest, or
compromise any encumbrance, charge, or lien which in Bank’s determination appears to be prior or superior to its security interest and to pay all expenses incurred in connection therewith. With respect to any of Borrower’s owned premises,
Borrower hereby grants Bank a license to enter into possession of such premises and to occupy the same, without charge, in order to exercise any of Bank’s rights or remedies provided herein, at law, in equity, or otherwise; 
 (f) Set off and apply to the Obligations any and all (i) balances and deposits of Borrower held by Bank, and (ii) indebtedness
at any time owing to or for the credit or the account of Borrower held by Bank; 
 (g) Ship, reclaim, recover, store, finish,
maintain, repair, prepare for sale, advertise for sale, and sell (in the manner provided for herein) the Collateral. Bank is hereby granted a license or other right, solely pursuant to the provisions of this Section 9.1, to use, without charge,
Borrower’s labels, patents, copyrights, rights of use of any name, trade secrets, trade names, trademarks, service marks, and advertising matter, or any property of a similar nature, as it pertains to the Collateral, in completing production
of, advertising for sale, and selling any Collateral and, in connection with Bank’s exercise of its rights under this Section 9.1, Borrower’s rights under all licenses and all franchise agreements shall inure to Bank’s benefit;

  

 - 18 - 

 (h) Sell the Collateral at either a public or private sale, or both, by way of one or
more contracts or transactions, for cash or on terms, in such manner and at such places (including Borrower’s premises) as Bank determines is commercially reasonable, and apply any proceeds to the Obligations in whatever manner or order Bank
deems appropriate. Bank may sell the Collateral without giving any warranties as to the Collateral. Bank may specifically disclaim any warranties of title or the like. This procedure will not be considered adversely to affect the commercial
reasonableness of any sale of the Collateral. If Bank sells any of the Collateral upon credit, Borrower will be credited only with payments actually made by the purchaser, received by Bank, and applied to the indebtedness of the purchaser. If the
purchaser fails to pay for the Collateral, Bank may resell the Collateral and Borrower shall be credited with the proceeds of the sale; 
 (i) Bank may credit bid and purchase at any public sale; 
 (j) Apply for the appointment of a
receiver, trustee, liquidator or conservator of the Collateral, without notice and without regard to the adequacy of the security for the Obligations and without regard to the solvency of Borrower, any guarantor or any other Person liable for any of
the Obligations; and 
 (k) Any deficiency that exists after disposition of the Collateral as provided above will be paid
immediately by Borrower. 
 Bank may comply with any applicable state or federal law requirements in connection with a disposition of the Collateral and
compliance will not be considered adversely to affect the commercial reasonableness of any sale of the Collateral. 
 9.2
Power of Attorney. Effective only upon the occurrence and during the continuance of an Event of Default, Borrower hereby irrevocably appoints Bank (and any of Bank’s designated officers, or employees) as Borrower’s true and lawful
attorney to: (a) send requests for verification of Accounts or notify account debtors of Bank’s security interest in the Accounts; (b) endorse Borrower’s name on any checks or other forms of payment or security that may come into
Bank’s possession; (c) sign Borrower’s name on any invoice or bill of lading relating to any Account, drafts against account debtors, schedules and assignments of Accounts, verifications of Accounts, and notices to account debtors;
(d) dispose of any Collateral; (e) make, settle, and adjust all claims under and decisions with respect to Borrower’s policies of insurance; (f) settle and adjust disputes and claims respecting the accounts directly with account
debtors, for amounts and upon terms which Bank determines to be reasonable; and (g) to file, in its sole discretion, one or more financing or continuation statements and amendments thereto, relative to any of the Collateral without the
signature of Borrower where permitted by law; provided Bank may exercise such power of attorney to sign the name of Borrower on any of the documents described in clause (g) above, regardless of whether an Event of Default has occurred. The
appointment of Bank as Borrower’s attorney in fact, and each and every one of Bank’s rights and powers, being coupled with an interest, is irrevocable until all of the Obligations have been fully repaid and performed and Bank’s
obligation to provide Credit Extensions hereunder is terminated. 
 9.3 Accounts Collection. At any time after the
occurrence and during the continuance of an Event of Default, Bank may notify any Person owing funds to Borrower of Bank’s security interest in such funds and verify the amount of such Account. At any time after the occurrence and during the
continuance of an Event of Default, Borrower shall collect all amounts owing to Borrower for Bank, receive in trust all payments as Bank’s trustee, and immediately deliver such payments to Bank in their original form as received from the
account debtor, with proper endorsements for deposit. 
 9.4 Bank Expenses. If Borrower fails to pay any amounts or
furnish any required proof of payment due to third persons or entities, as required under the terms of this Agreement, then Bank may do any or all of the following after reasonable notice to Borrower: (a) make payment of the same or any part
thereof; (b) set up such reserves under the Revolving Line as Bank deems necessary to protect Bank from the exposure created by such failure; or (c) obtain and maintain insurance policies of the type discussed in Section 6.5 of this
Agreement, and take any action with respect to such policies as Bank deems prudent. Any amounts so paid or deposited by Bank shall constitute Bank Expenses, shall be immediately due and payable, and shall bear interest at the then applicable rate
hereinabove provided, and shall be secured by the Collateral. Any payments made by Bank shall not constitute an agreement by Bank to make similar payments in the future or a waiver by Bank of any Event of Default under this Agreement. 
  

 - 19 - 

 9.5 Bank’s Liability for Collateral. Bank has no obligation to clean up or
otherwise prepare the Collateral for sale. All risk of loss, damage or destruction of the Collateral shall be borne by Borrower. 
 9.6 No Obligation to Pursue Others. Bank has no obligation to attempt to satisfy the Obligations by collecting them from any other Person liable for them and Bank may release, modify or waive any collateral provided by any other
Person to secure any of the Obligations, all without affecting Bank’s rights against Borrower. Borrower waives any right it may have to require Bank to pursue any other Person for any of the Obligations. 
 9.7 Remedies Cumulative. Bank’s rights and remedies under this Agreement, the Loan Documents, and all other agreements shall
be cumulative. Bank shall have all other rights and remedies not inconsistent herewith as provided under the Code, by law, or in equity. No exercise by Bank of one right or remedy shall be deemed an election, and no waiver by Bank of any Event of
Default on Borrower’s part shall be deemed a continuing waiver. No delay by Bank shall constitute a waiver, election, or acquiescence by it. No waiver by Bank shall be effective unless made in a written document signed on behalf of Bank and
then shall be effective only in the specific instance and for the specific purpose for which it was given. Borrower expressly agrees that this Section may not be waived or modified by Bank by course of performance, conduct, estoppel or otherwise.

 9.8 Demand; Protest. Except as otherwise provided in this Agreement, Borrower waives demand, protest, notice of
protest, notice of default or dishonor, notice of payment and nonpayment and any other notices relating to the Obligations. 
 10.
NOTICES. 
 Unless otherwise provided in this Agreement, all notices or demands by any party relating to this Agreement
or any other agreement entered into in connection herewith shall be in writing and (except for financial statements and other informational documents which may be sent by first-class mail, postage prepaid) shall be personally delivered or sent by a
recognized overnight delivery service, certified mail, postage prepaid, return receipt requested, or by telefacsimile to Borrower or to Bank, as the case may be, at its addresses set forth below: 
  

			
	If to Borrower:	  	TPTX, INC.
		  	11085 N. Torrey Pines Road, Suite 300
		  	La Jolla, CA 92037
		  	Attn: Chief Financial Officer
		  	FAX: (858) 623-5666
		
	If to Bank:	  	Comerica Bank
		  	75 East Trimble Road, M/C 4770
		  	San Jose, California 95131
		  	Attn: Manager
		  	FAX: (408) 556-5091
		
	with a copy to:	  	Comerica Bank
		  	11943 El Camino Real, Suite 110B
		  	San Diego, CA 92130
		  	Attn: Greg Park
		  	FAX: (858) 509-2365

 The parties hereto may change the address at which they are to receive notices hereunder, by
notice in writing in the foregoing manner given to the other. 
  

 - 20 - 

 11. CHOICE OF LAW AND VENUE; JURY TRIAL WAIVER. 
 This Agreement shall be governed by, and construed in accordance with, the internal laws of the State of California, without regard to principles of
conflicts of law. Each of Borrower and Bank hereby submits to the exclusive jurisdiction of the state and Federal courts located in the State of California. THE UNDERSIGNED ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A CONSTITUTIONAL ONE, BUT
THAT IT MAY BE WAIVED UNDER CERTAIN CIRCUMSTANCES. TO THE EXTENT PERMITTED BY LAW, EACH PARTY, AFTER CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF ITS, HIS OR HER CHOICE, KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT
OF ALL PARTIES, WAIVES ANY RIGHT TO TRIAL BY JURY IN THE EVENT OF LITIGATION ARISING OUT OF OR RELATED TO THIS AGREEMENT OR ANY OTHER DOCUMENT, INSTRUMENT OR AGREEMENT BETWEEN THE UNDERSIGNED PARTIES. 
 12. REFERENCE PROVISION. 
 In the
event the Jury Trial Waiver set forth above is not enforceable, the parties elect to proceed under this Judicial Reference Provision. 
 12.1 Mechanics. 
 (a) With the exception of the items specified in clause (b), below,
any controversy, dispute or claim (each, a “Claim”) between the parties arising out of or relating to this Agreement or any other document, instrument or agreement between the undersigned parties (collectively in this Section, the
“Comerica Documents”), will be resolved by a reference proceeding in California in accordance with the provisions of Sections 638 et seq. of the California Code of Civil Procedure (“CCP”), or their successor sections, which shall
constitute the exclusive remedy for the resolution of any Claim, including whether the Claim is subject to the reference proceeding. Except as otherwise provided in the Comerica Documents, venue for the reference proceeding will be in the state or
federal court in the county or district where the real property involved in the action, if any, is located or in the state or federal court in the county or district where venue is otherwise appropriate under applicable law (the “Court”).

 (b) The matters that shall not be subject to a reference are the following: (i) nonjudicial foreclosure of any
security interests in real or personal property, (ii) exercise of self-help remedies (including, without limitation, set-off), (iii) appointment of a receiver and (iv) temporary, provisional or ancillary remedies (including, without
limitation, writs of attachment, writs of possession, temporary restraining orders or preliminary injunctions). This reference provision does not limit the right of any party to exercise or oppose any of the rights and remedies described in clauses
(i) and (ii) or to seek or oppose from a court of competent jurisdiction any of the items described in clauses (iii) and (iv). The exercise of, or opposition to, any of those items does not waive the right of any party to a reference
pursuant to this reference provision as provided herein. 
 (c) The referee shall be a retired judge or justice selected by
mutual written agreement of the parties. If the parties do not agree within ten (10) days of a written request to do so by any party, then, upon request of any party, the referee shall be selected by the Presiding Judge of the Court (or his or
her representative). A request for appointment of a referee may be heard on an ex parte or expedited basis, and the parties agree that irreparable harm would result if ex parte relief is not granted. Pursuant to CCP § 170.6, each party shall
have one peremptory challenge to the referee selected by the Presiding Judge of the Court (or his or her representative). 
 (d) The parties agree that time is of the essence in conducting the reference proceedings. Accordingly, the referee shall be requested, subject to change in the time periods specified herein for good cause shown, to (i) set the matter
for a status and trial-setting conference within fifteen (15) days after the date of selection of the referee, (ii) if practicable, try all issues of law or fact within one hundred twenty (120) days after the date of the conference
and (iii) report a statement of decision within twenty (20) days after the matter has been submitted for decision. 
  

 - 21 - 

 (e) The referee will have power to expand or limit the amount and duration of discovery.
The referee may set or extend discovery deadlines or cutoffs for good cause, including a party’s failure to provide requested discovery for any reason whatsoever. Unless otherwise ordered based upon good cause shown, no party shall be entitled
to “priority” in conducting discovery, depositions may be taken by either party upon seven (7) days written notice, and all other discovery shall be responded to within fifteen (15) days after service. All disputes relating to
discovery which cannot be resolved by the parties shall be submitted to the referee whose decision shall be final and binding. 
 12.2 Procedures. Except as expressly set forth herein, the referee shall determine the manner in which the reference proceeding is conducted including the time and place of hearings, the order of presentation of evidence, and all
other questions that arise with respect to the course of the reference proceeding. All proceedings and hearings conducted before the referee, except for trial, shall be conducted without a court reporter, except that when any party so requests, a
court reporter will be used at any hearing conducted before the referee, and the referee will be provided a courtesy copy of the transcript. The party making such a request shall have the obligation to arrange for and pay the court reporter. Subject
to the referee’s power to award costs to the prevailing party, the parties will equally share the cost of the referee and the court reporter at trial. 
 12.3 Application of Law. The referee shall be required to determine all issues in accordance with existing case law and the statutory laws of the State of California. The rules of evidence applicable to
proceedings at law in the State of California will be applicable to the reference proceeding. The referee shall be empowered to enter equitable as well as legal relief, enter equitable orders that will be binding on the parties and rule on any
motion which would be authorized in a court proceeding, including without limitation motions for summary judgment or summary adjudication. The referee shall issue a decision at the close of the reference proceeding which disposes of all claims of
the parties that are the subject of the reference. Pursuant to CCP § 644, such decision shall be entered by the Court as a judgment or an order in the same manner as if the action had been tried by the Court and any such decision will be final,
binding and conclusive. The parties reserve the right to appeal from the final judgment or order or from any appealable decision or order entered by the referee. The parties reserve the right to findings of fact, conclusions of laws, a written
statement of decision, and the right to move for a new trial or a different judgment, which new trial, if granted, is also to be a reference proceeding under this provision. 
 12.4 Repeal. If the enabling legislation which provides for appointment of a referee is repealed (and no successor statute is
enacted), any dispute between the parties that would otherwise be determined by reference procedure will be resolved and determined by arbitration. The arbitration will be conducted by a retired judge or justice, in accordance with the California
Arbitration Act §1280 through §1294.2 of the CCP as amended from time to time. The limitations with respect to discovery set forth above shall apply to any such arbitration proceeding. 
 12.5 THE PARTIES RECOGNIZE AND AGREE THAT ALL CONTROVERSIES, DISPUTES AND CLAIMS RESOLVED UNDER THIS REFERENCE PROVISION WILL BE DECIDED
BY A REFEREE AND NOT BY A JURY. AFTER CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF ITS, HIS OR HER OWN CHOICE, EACH PARTY KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL PARTIES, AGREES THAT THIS REFERENCE
PROVISION WILL APPLY TO ANY CONTROVERSY, DISPUTE OR CLAIM BETWEEN OR AMONG THEM ARISING OUT OF OR IN ANY WAY RELATED TO, THIS AGREEMENT OR THE OTHER COMERICA DOCUMENTS. 
 13. GENERAL PROVISIONS. 
 13.1 Successors and Assigns. This Agreement shall
bind and inure to the benefit of the respective successors and permitted assigns of each of the parties and shall bind all Persons who become bound as a debtor to this Agreement; provided, however, that neither this Agreement nor any rights
hereunder may be assigned by Borrower without Bank’s prior written consent, which consent may be granted or withheld in Bank’s sole discretion. Bank shall have the right without the consent of or notice to Borrower to sell, transfer,
negotiate, or grant participation in all or any part of, or any interest in, Bank’s obligations, rights and benefits hereunder. 
  

 - 22 - 

 13.2 Indemnification. Borrower shall defend, indemnify and hold harmless Bank and
its officers, employees, and agents against: (a) all obligations, demands, claims, and liabilities claimed or asserted by any other party in connection with the transactions contemplated by this Agreement; and (b) all losses or Bank
Expenses in any way suffered, incurred, or paid by Bank, its officers, employees and agents as a result of or in any way arising out of, following, or consequential to transactions between Bank and Borrower whether under this Agreement, or otherwise
(including without limitation reasonable attorneys’ fees and expenses), except for losses caused by Bank’s gross negligence or willful misconduct. 
 13.3 Time of Essence. Time is of the essence for the performance of all obligations set forth in this Agreement. 
 13.4 Severability of Provisions. Each provision of this Agreement shall be severable from every other provision of this Agreement
for the purpose of determining the legal enforceability of any specific provision. 
 13.5 Amendments in Writing,
Integration. All amendments to or terminations of this Agreement or the other Loan Documents must be in writing. All prior agreements, understandings, representations, warranties, and negotiations between the parties hereto with respect to the
subject matter of this Agreement and the other Loan Documents, if any, are merged into this Agreement and the Loan Documents. 
 13.6 Counterparts. This Agreement may be executed in any number of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, shall be deemed to be an original, and all of which, when
taken together, shall constitute but one and the same Agreement. 
 13.7 Survival. All covenants, representations and
warranties made in this Agreement shall continue in full force and effect so long as any Obligations remain outstanding or Bank has any obligation to make any Credit Extension to Borrower. The obligations of Borrower to indemnify Bank with respect
to the expenses, damages, losses, costs and liabilities described in Section 13.2 shall survive until all applicable statute of limitations periods with respect to actions that may be brought against Bank have run. 
 13.8 Confidentiality. In handling any confidential information, Bank and all employees and agents of Bank shall exercise the same
degree of care that Bank exercises with respect to its own proprietary information of the same types to maintain the confidentiality of any non-public information thereby received or received pursuant to this Agreement except that disclosure of such
information may be made (i) to the subsidiaries or Affiliates of Bank in connection with their present or prospective business relations with Borrower, (ii) to prospective transferees or purchasers of any interest in the Loans, provided
that they have entered into a comparable confidentiality agreement in favor of Borrower and have delivered a copy to Borrower, (iii) as required by law, regulations, rule or order, subpoena, judicial order or similar order, (iv) as may be
required in connection with the examination, audit or similar investigation of Bank and (v) as Bank may determine in connection with the enforcement of any remedies hereunder. Confidential information hereunder shall not include information
that either: (a) is in the public domain or in the knowledge or possession of Bank when disclosed to Bank, or becomes part of the public domain after disclosure to Bank through no fault of Bank; or (b) is disclosed to Bank by a third
party; provided that Bank does not have actual knowledge that such third party is prohibited from disclosing such information. 
 [Balance of Page Intentionally Left Blank] 
  

 - 23 - 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as of the date first
above written. 
  

			
	TPTX, INC.
		
	By:	 	/s/ Craig A. Johnson
	Title:	 	Chief Financial Officer

  

			
	COMERICA BANK
		
	 By:
	 	 /s/ Greg Park

	Title:	 	 Vice President

 [Signature Page to Loan and Security Agreement] 
  

 - 24 - 

			
	DEBTOR	  	TPTX, INC.
		
	SECURED PARTY:	  	COMERICA BANK

 EXHIBIT A 
 COLLATERAL DESCRIPTION ATTACHMENT 
 TO LOAN AND SECURITY AGREEMENT 
 All personal property of Borrower (herein referred to as “Borrower” or “Debtor”) whether presently existing or hereafter created or
acquired, and wherever located, including, but not limited to: 
 (a) all accounts (including health-care-insurance
receivables), chattel paper (including tangible and electronic chattel paper), deposit accounts, documents (including negotiable documents), equipment (including all accessions and additions thereto), general intangibles (including payment
intangibles and software), goods (including fixtures), instruments (including promissory notes), inventory (including all goods held for sale or lease or to be furnished under a contract of service, and including returns and repossessions),
investment property (including securities and securities entitlements), letter of credit rights, money, and all of Debtor’s books and records with respect to any of the foregoing, and the computers and equipment containing said books and
records; and 
 (b) any and all cash proceeds and/or noncash proceeds of any of the foregoing, including, without limitation,
insurance proceeds, and all supporting obligations and the security therefor or for any right to payment. All terms above have the meanings given to them in the California Uniform Commercial Code, as amended or supplemented from time to time,
including revised Division 9 of the Uniform Commercial Code-Secured Transactions, added by Stats. 1999, c.991 (S.B. 45), Section 35, operative July 1, 2001. 
 Notwithstanding the foregoing, the Collateral shall not include any copyrights, patents, trademarks, servicemarks and applications therefor, now owned or hereafter acquired, or any claims for damages by way of any
past, present and future infringement of any of the foregoing (collectively, the “Intellectual Property”); provided, however, that the Collateral shall include all accounts and general intangibles that consist of rights to payment and
proceeds from the sale, licensing or disposition of all or any part, or rights in, the foregoing (the “Rights to Payment”). Notwithstanding the foregoing, if a judicial authority (including a U.S. Bankruptcy Court) holds that a security
interest in the underlying Intellectual Property is necessary to have a security interest in the Rights to Payment, then the Collateral shall automatically, and effective as of June 11, 2008, include the Intellectual Property to the extent
necessary to permit perfection of Bank’s security interest in the Rights to Payment. 

 EXHIBIT B 
 TECHNOLOGY & LIFE SCIENCES DIVISION 
 LOAN ANALYSIS 
 LOAN ADVANCE/PAYDOWN REQUEST FORM 
 DEADLINE FOR SAME DAY PROCESSING IS [3:00* P.M., Pacific Time/ 3:30 P.M. Eastern Time] 
 FORMULA BASED LINES: DEADLINE FOR
NEXT DAY PROCESSING IS [3:00* P.M., Pacific Time/ 3:30 P.M. Eastern Time] 
 DEADLINE FOR EQUIPMENT ADVANCES IS [3:00 P.M., Pacific Time/ 3:30
P.M. Eastern Time ]** 
 DEADLINE FOR WIRE TRANSFERS IS [1:30 P.M., Pacific Time/ 3:30 P.M. Eastern Time] 
 [*At month end and the day before a holiday, the cut off time is 1:30 P.M., Pacific Time] 
 **Subject to 3 day advance notice. 
   To: Loan
Analysis                                        
                      DATE: ________________    TIME: _________________ 
   FAX #: (650) 846-6840 

											
	 FROM:
	  	 TPTX, INC.
 Borrower’s Name
	  	TELEPHONE REQUEST (For Bank Use Only):
	FROM:	  	 __________________________
 Authorized Signer’s Name

	  	 The following person is authorized to request the loan payment
 transfer/loan advance on the designated account and is known to me.

	FROM:	  	 __________________________
 Authorized Signer’s Name

	  	 _________________________________________________
 Authorized Request & Phone #

	PHONE #:	  	__________________________	  	 _________________________________________________
 Received by (Bank) & Phone #

	 FROM
 ACCOUNT#:
	  		  	
	(please include Note number, if applicable)	  	
	TO ACCOUNT #:	  		  	Authorized Signature (Bank)
	(please include Note number, if applicable)	  	
	REQUESTED TRANSACTION TYPE	  	REQUESTED DOLLAR AMOUNT	  	For Bank Use Only
				
	PRINCIPAL INCREASE* (ADVANCE)	  	$______________________________	  	Date Rec’d:	  	
	PRINCIPAL PAYMENT (ONLY)	  	$______________________________	  	Time:	  	
		  		  		  	Comp. Status:	  	YES    	  	NO    
	OTHER INSTRUCTIONS:	  		  	Status Date:	  	
	_______________________________________________________________________________	  	Time:	  	
	_______________________________________________________________________________	  	Approval:	  		  	
		  		  		  		  		  	

 All representations and warranties of Borrower stated in the Loan Agreement are true, correct and complete in all
material respects as of the date of the telephone request for and advance confirmed by this Borrowing Certificate; provided, however, that those representations and warranties the date expressly referring to another date shall be true, correct and
complete in all material respects as of such date. 
  

									
	*IS THERE A WIRE REQUEST TIED TO THIS LOAN ADVANCE? (PLEASE CIRCLE ONE	  	    YES	  	NO
	If YES, the Outgoing Wire Transfer Instructions must be completed below.	  		  	
	OUTGOING WIRE TRANSFER INSTRUCTIONS	  	Fed Reference Number	  	Bank Transfer Number
	The items marked with an asterisk (*) are required to be completed.
	 *Beneficiary Name
	 	
	 *Beneficiary Account Number
	 	
	 *Beneficiary Address
	 	
	 Currency Type
	 	US DOLLARS ONLY
	 *ABA Routing Number (9 Digits)
	 	
	 *Receiving Institution Name
	 	
	 *Receiving Institution Address
	 	
	 *Wire Account
	 	$

 EXHIBIT C 
 COMPLIANCE CERTIFICATE 
  

			
	TO:	  	COMERICA BANK
		
	FROM:	  	TPTX, INC.

 The undersigned authorized officer of TPTX, INC. hereby certifies that in accordance with the
terms and conditions of the Loan and Security Agreement between Borrower and Bank (the “Agreement”), (i) Borrower is in complete compliance for the period ending
                     with all required covenants except as noted below and (ii) all representations and warranties of Borrower stated in
the Agreement are true and correct in all material respects as of the date hereof. Attached herewith are the required documents supporting the above certification. The Officer further certifies that these are prepared in accordance with Generally
Accepted Accounting Principles (GAAP) and are consistently applied from one period to the next except as explained in an accompanying letter or footnotes. 
 Please indicate compliance status by circling Yes/No under “Complies” column. 
  

										
	 Reporting Covenant
	  	 Required
	  	 Complies

	 10K and 10Q
	  	When filed	  	Yes	  	No
	 Compliance Cert.
	  	Monthly within 30 days	  	Yes	  	No
	 A/R Audit
	  	Annual	  	Yes	  	No
	 Total amount of Borrower’s cash and investments
	  	Amount: $            	  	Yes	  	No
	Total amount of Borrower’s cash and investments maintained with Bank	  	Amount: $            	  	Yes	  	No
				
	 Financial Covenant
	  	 Required
	  	Actual	  	Complies
	 Measured at All Times::
	  		  			  		  	
	 Minimum Cash
	  	$5,400,000	  	$	            	  	Yes	  	No

  

									
	Comments Regarding Exceptions: See Attached.	  		  	BANK USE ONLY	  	
					
		  		  		  	Received by: _______________________________	  	
	 Sincerely,
	  		  		  	            AUTHORIZED SIGNER	  	
		  		  		  	Date:     ___________________________________	  	
					
		  	  
	  		  	Verified: __________________________________	  	
		  	SIGNATURE	  		  	AUTHORIZED SIGNER	  	
		  	  
	  		  	Date:     ___________________________________	  	
		  	TITLE	  		  		  	
		  	  
	  		  	Compliance Status
                            Yes            
No        	  	
		  	DATE	  		  		  	

 SCHEDULE OF EXCEPTIONS 
 Permitted Indebtedness (Section 1.1) 
 None. 
 Permitted Investments (Section 1.1) 
 None. 
 Permitted Liens (Section 1.1) 
 None. 
 Permitted Transfers (Section 1.1) 
 See Annex I attached hereto. 
 Invested Collateral (Section 5.3) 
 Borrower maintains a balance in
certain accounts located in Belgium in the ordinary course of business. 
 Prior Names (Section 5.5) 
 TorreyPines Therapeutics, Inc. 
 Neurogenetics, Inc. 
 Litigation (Section 5.6) 
 Several lawsuits were filed against us
in February 2005 in the U.S. District Court for the Southern District of New York asserting claims under Sections 10(b) and 20(a) of the Securities Exchange Act of 1934, as amended, or the Exchange Act and Rule 10b-5 thereunder on behalf of a class
of purchasers of our common stock during the period from June 26, 2003, through and including February 4, 2005, referred to as the class period. Dr. Marvin S. Hausman, M.D., a former director and our former Chief Executive
Officer, and Dr. Gosse B. Bruinsma, M.D., also a former director and our former Chief Executive Officer, were also named as defendants in the lawsuits. These actions were consolidated into a single class action lawsuit in January 2006. On
April 10, 2006, the class action plaintiffs filed an amended consolidated complaint. We filed our answer to that complaint on May 26, 2006. Our motion to dismiss the consolidated amended complaint was filed on May 26, 2006 and was
submitted to the court for a decision in September 2006. The motion to dismiss is pending. 
 The class action plaintiffs allege generally that our Phase III
phenserine development program was subject to alleged errors of design and execution which resulted in the failure of the first Phase III phenserine trial to show efficacy. Plaintiffs allege the defendants’ failure to disclose the alleged
defects resulted in the artificial inflation of the price of our shares during the class period. 
 There is also a shareholder derivative suit pending in
New York Supreme Court, New York County, against our current and former directors and officers. The named defendants are Marvin S. Hausman, M.D., Gosse B. Bruinsma, M.D., S. Colin Neill, Louis G. Cornacchia, Steven H. Ferris, Ph.D., Gerard J. Vlak,
Ralph Snyderman, M.D. and Michael A. Griffith. Defendants are alleged to have breached their duties to the company and misused inside information regarding clinical trials of phenserine. This action has been stayed pending further developments in
the federal class action. 
 Inbound Licenses (Section 5.12) 
 None. 

 Annex I to the Schedule of Exceptions 
 1. The Company’s Gamma Secretase Modulator (GSM) Program, including, without limitation, patent 7,244,739 issued on July 17, 2007 and any other
patents, patent applications, trademarks, trade names, service marks, copyrights, technology, trade secrets, proprietary information, know-how and processes relating to such program. 
 2. The Company’s Alzheimer’s disease genetics program, including, without limitation, any patents, patent applications, trademarks, trade names, service marks, copyrights, technology, trade secrets,
proprietary information, know-how and processes relating to such program. 

 Corporation Resolutions and Incumbency Certification 
 Authority to Procure Loans 
 I certify that I am the
duly elected and qualified Secretary of TPTX, INC.; that the following is a true and correct copy of resolutions duly adopted by the Board of Directors of the Corporation in accordance with its bylaws and applicable statutes. 
 Copy of Resolutions: 
 Be it Resolved, That: 
  

	1.	Any one (1) of the following
                             (insert titles only) of the Corporation are/is authorized, for, on behalf
of, and in the name of the Corporation to: 

  

	 	(a)	Negotiate and procure loans, letters of credit and other credit or financial accommodations from Comerica Bank (“Bank”), a Texas banking association, including, without
limitation, that certain Loan and Security Agreement dated as of June 11, 2008, as may subsequently be amended from time to time. 

  

	 	(b)	Discount with the Bank, commercial or other business paper belonging to the Corporation made or drawn by or upon third parties, without limit as to amount; 

 

	 	(c)	Purchase, sell, exchange, assign, endorse for transfer and/or deliver certificates and/or instruments representing stocks, bonds, evidences of Indebtedness or other securities owned
by the Corporation, whether or not registered in the name of the Corporation; 

  

	 	(d)	Give security for any liabilities of the Corporation to the Bank by grant, security interest, assignment, lien, deed of trust or mortgage upon any real or personal property,
tangible or intangible of the Corporation; 

  

	 	(e)	Issue a warrant or warrants to purchase the Corporation’s capital stock; and 

  

	 	(f)	Execute and deliver in form and content as may be required by the Bank any and all notes, evidences of Indebtedness, applications for letters of credit, guaranties, subordination
agreements, loan and security agreements, financing statements, assignments, liens, deeds of trust, mortgages, trust receipts and other agreements, instruments or documents to carry out the purposes of these Resolutions, any or all of which may
relate to all or to substantially all of the Corporation’s property and assets. 

  

	2.	Said Bank be and it is authorized and directed to pay the proceeds of any such loans or discounts as directed by the persons so authorized to sign, whether so payable to the order
of any of said persons in their individual capacities or not, and whether such proceeds are deposited to the individual credit of any of said persons or not; 

  

	3.	Any and all agreements, instruments and documents previously executed and acts and things previously done to carry out the purposes of these Resolutions are ratified, confirmed and
approved as the act or acts of the Corporation. 

  

	4.	These Resolutions shall continue in force, and the Bank may consider the holders of said offices and their signatures to be and continue to be as set forth in a certified copy of
these Resolutions delivered to the Bank, until notice to the contrary in writing is duly served on the Bank (such notice to have no effect on any action previously taken by the Bank in reliance on these Resolutions). 

  

 - 1 - 

	5.	Any person, corporation or other legal entity dealing with the Bank may rely upon a certificate signed by an officer of the Bank to effect that these Resolutions and any agreement,
instrument or document executed pursuant to them are still in full force and effect and binding upon the Corporation. 

  

	6.	The Bank may consider the holders of the offices of the Corporation and their signatures, respectively, to be and continue to be as set forth in the Certificate of the Secretary of
the Corporation until notice to the contrary in writing is duly served on the Bank. 

 I further certify that the above Resolutions are in full
force and effect as of the date of this Certificate; that these Resolutions and any borrowings or financial accommodations under these Resolutions have been properly noted in the corporate books and records, and have not been rescinded, annulled,
revoked or modified; that neither the foregoing Resolutions nor any actions to be taken pursuant to them are or will be in contravention of any provision of the articles of incorporation or bylaws of the Corporation or of any agreement, indenture or
other instrument to which the Corporation is a party or by which it is bound; and that neither the articles of incorporation nor bylaws of the Corporation nor any agreement, indenture or other instrument to which the Corporation is a party or by
which it is bound require the vote or consent of shareholders of the Corporation to authorize any act, matter or thing described in the foregoing Resolutions. 
 I further certify that the following named persons have been duly elected to the offices set opposite their respective names, that they continue to hold these offices at the present time, and that the signatures which appear below are the
genuine, original signatures of each respectively: 
 (PLEASE SUPPLY GENUINE SIGNATURES OF AUTHORIZED SIGNERS BELOW) 
  

					
	 NAME (Type or Print)
	  	 TITLE
	  	 SIGNATURE

	  
	  	  
	  	  

	  
	  	  
	  	  

	  
	  	  
	  	  

	  
	  	  
	  	  

	  
	  	  
	  	  

	  
	  	  
	  	  

 In Witness Whereof, I have affixed my name as Secretary and have caused the corporate seal (where available) of
said Corporation to be affixed on June 11, 2008. 
  

	
	
	  
	Secretary

					
			
	The Above Statements are Correct.	 		 	  
		 		 	SIGNATURE OF OFFICER OR DIRECTOR OR, IF NONE. A SHAREHOLDER OTHER THAN SECRETARY WHEN SECRETARY IS AUTHORIZED TO SIGN ALONE.

 Failure to complete the above when the Secretary is authorized to sign alone shall constitute a certification
by the Secretary that the Secretary is the sole Shareholder, Director and Officer of the Corporation. 

 ATTN: TPTX, INC. 
 USA PATRIOT ACT 
 NOTICE 
 OF 
 CUSTOMER IDENTIFICATION 
 IMPORTANT INFORMATION ABOUT PROCEDURES FOR OPENING A NEW ACCOUNT 
 To help the government fight the funding of terrorism and money laundering activities, Federal law requires all financial institutions to obtain, verify, and record information that identifies each person who opens an
account. 
 WHAT THIS MEANS FOR YOU: when you open an account, we will ask your name, address, date of birth, and other information that will
allow us to identify you. We may also ask to see your driver’s license or other identifying documents. 

 COMERICA BANK 
 Member FDIC 
 ITEMIZATION OF AMOUNT FINANCED 
 DISBURSEMENT INSTRUCTIONS 
 (Term
Loan) 
  

			
	Name(s): TPTX, INC.	  	        Date: June 11, 2008
		
	 $3,600,000
	  	credited to deposit account No. ___________ when Advances are requested by Borrower
	
	Amounts paid to others on your behalf:
		
	 $
	  	to Comerica Bank for Loan Fee
		
	 $
	  	to Comerica Bank for Document Fee
		
	 $
	  	to Bank counsel fees and expenses
		
	 $
	  	to _______________
		
	 $
	  	to _______________
		
	 $
	  	TOTAL (AMOUNT FINANCED)

 Upon consummation of this transaction, this document will also serve as the authorization for
Comerica Bank to disburse the loan proceeds as stated above. 
  

					
			
	  	 		 	  
	Signature	 		 	Signature

 

 
 Agreement to Furnish Insurance 
 (Herein called “Bank”) 
 Borrower(s): TPTX, INC. 
 I understand that the Security Agreement or Deed of Trust which I executed in connection with this transaction requires me to provide a physical damage insurance policy including a Lenders Loss Payable Endorsement in
favor of the Bank as shown below, within ten (10) days from the date of this agreement. 
 The following minimum insurance must be provided according to
the terms of the security documents. 
  

							
	  ̈
	 	AUTOMOBILES, TRUCKS, RECREATIONAL VEHICLES	  	 ̈	  	MACHINERY & EQUIPMENT: MISCELLANEOUS PERSONAL PROPERTY
				
		 	 Comprehensive & Collision
	  		  	 Fire & Extended Coverage

		 	 Lender’s Loss Payable Endorsement
	  		  	 Lender’s Loss Payable Endorsement

		 		  		  	  ̈        Breach of Warranty Endorsement

	  ̈
	 	BOATS	  	 ̈	  	AIRCRAFT
		 	 All Risk Hull Insurance
	  		  	 All Risk Ground & Flight Insurance

		 	 Lender’s Loss Payable Endorsement
	  		  	 Lender’s Loss Payable Endorsement

		 	  ̈        Breach of Warranty Endorsement
	  		  	  ̈        Breach of Warranty Endorsement

	  ̈
	 	MOBILE HOMES	  	 ̈	  	REAL PROPERTY
		 	 Fire, Theft & Combined Additional Coverage
	  		  	 Fire & Extended Coverage

		 	 Lender’s Loss Payable Endorsement
	  		  	 Lender’s Loss Payable Endorsement

		 	  ̈        Earthquake
	  		  	  ̈        All Risk Coverage

		 		  		  	  ̈        Special Form Risk Coverage

		 		  		  	  ̈        

		 		  		  	  ̈        Earthquake

	  ̈
	 	INVENTORY	  		  	  ̈        Other
_____________________________

		
	  ̈
	 	Other ____________________________________________________________________________________________
		 	            ____________________________________________________________________________________________
		
		 	            ____________________________________________________________________________________________

 I may obtain the required insurance from any company that is acceptable to the Bank, and will deliver proof of
such coverage with an effective date of June 11, 2008 or earlier. 
 I understand and agree that if I fail to deliver proof of insurance to the Bank at
the address below, or upon the lapse or cancellation of such insurance, the Bank may procure Lender’s Single Interest Insurance or other similar coverage on the property. If the Bank procures insurance to protect its interest in the property
described in the security documents, the cost for the insurance will be added to my indebtedness as provided in the security documents. Lender’s Single Interest Insurance shall cover only the Bank’s interest as a secured party, and shall
become effective at the earlier of the funding date of this transaction or the date my insurance was canceled or expired. I UNDERSTAND THAT LENDER’S SINGLE INTEREST INSURANCE WILL PROVIDE ME WITH ONLY LIMITED PROTECTION AGAINST PHYSICAL DAMAGE
TO THE COLLATERAL, UP TO THE BALANCE OF THE LOAN, HOWEVER, MY EQUITY IN THE PROPERTY WILL NOT BE INSURED. FURTHER, THE INSURANCE WILL NOT PROVIDE MINIMUM PUBLIC LIABILITY OR PROPERTY DAMAGE INDEMNIFICATION AND DOES NOT MEET THE REQUIREMENTS OF THE
FINANCIAL RESPONSIBILITY LAW. 
 CALIFORNIA CIVIL CODE SECTION 2955.5. HAZARD INSURANCE DISCLOSURE: No lender shall require a borrower, as a condition of
receiving or maintaining a loan secured by real property, to provide hazard insurance coverage against risks to the improvements on that real property in an amount exceeding the replacement value of the improvements on the property. 
  

	
	Bank Address for Insurance Documents:
	  
 Comerica Bank – Collateral Operations, Mail Code
4770

	75 East Trimble Road
	San Jose, California 95131

 I acknowledge having read the provisions of this agreement, and agree to its terms. I authorize the Bank to provide to
any person (including any insurance agent or company) any information necessary to obtain the insurance coverage required. 
  

					
	 OWNER(S) OF COLLATERAL:
 TPTX, INC.
	 		 	DATED: June 11, 2008
			
	  	 		 	  
			
	  	 		 	  

  

					
	INSURANCE VERIFICATION	 		 	
			
	Date _________________________	 	Phone                                      
   	 	
	Agents Name _______________________________________	 	Person Talked To                      	 	

					
	Agents Address                                    
                                         
                                         
                                         
                                         
                           	 		 	
	Insurance
Company                                        
                                         
                                         
                                         
                                         
               	 		 	
	Policy
Number(s)                                       
                                         
                                         
                                         
                                         
                    	 		 	

					
	Effective Dates: From _________________________________	 	To: __________________________________________	 	
	Deductible $ ________________________________________	 	Comments: ____________________________________	 	

					
	COMERICA BANK
	 Member FDIC
	  	AUTOMATIC DEBIT AUTHORIZATION

  

	
	To: Comerica Bank
	
	Re: Loan #
                                         
                                 
	
	 You are hereby authorized and instructed to charge account No.
                                 in the name of TPTX, INC.
  

	for principal, interest and other payments due on above referenced loan as set forth below and credit the loan referenced above.

  

	 	x	Debit each interest payment as it becomes due according to the terms of the Loan and Security Agreement and any renewals or amendments thereof. 

  

	 	x	Debit each principal payment as it becomes due according to the terms of the Loan and Security Agreement and any renewals or amendments thereof. 

  

	 	x	Debit each payment for Bank Expenses as it becomes due according to the terms of the Loan and Security Agreement and any renewals or amendments thereof. 

 This Authorization is to remain in full force and effect until revoked in writing. 
  

					
	 Borrower Signature
	 		 	Date
			
	  	 		 	June 11, 2008
			
	  	 		 	June 11, 2008

					
	COMERICA BANK
	 Member FDIC
	  	AUTOMATIC DEBIT AUTHORIZATION

  

	
	To: Comerica Bank
	
	Re: Loan #
                                         
                                 
	
	You are hereby authorized and instructed to charge account No.
                             in the name of TPTX, INC.

 for principal, interest and other payments due on above referenced loan as set forth below and credit the loan
referenced above. 
  

	 	x	Debit each interest payment as it becomes due according to the terms of the Loan and Security Agreement and any renewals or amendments thereof. 

  

	 	x	Debit each principal payment as it becomes due according to the terms of the Loan and Security Agreement and any renewals or amendments thereof. 

  

	 	x	Debit each payment for Bank Expenses as it becomes due according to the terms of the Loan and Security Agreement and any renewals or amendments thereof. 

 This Authorization is to remain in full force and effect until revoked in writing. 
  

					
	 Borrower Signature
	 		 	Date
			
	  	 		 	June 11, 2008
			
	  	 		 	June 11, 2008

 COMERICA BANK 
  

			
	 	  	COMERICA BANK
	 	  	CLIENT AUTHORIZATION
	 Fax    (858) 509-2365
	  	

 General Authorization 
 I hereby authorize Comerica Bank to use my company name, logo, and information relating to our banking relationship in its marketing and advertising campaigns which is intended for Comerica Bank’s customers, prospects and shareholders.

 Comerica Bank will forward any advertising or article including client for prior review and approval. 
  

	
	
	  
	Signature
	
	  
	Printed Name                        Title
	
	  
	 Company

	
	  
	 Mailing Address

	
	  
	 City, State, Zip Code

	
	  
	 Phone Number

	
	  
	 Fax Number

	
	  
	 E-Mail

 June 11, 2008 

			
	DEBTOR	  	TPTX, INC.
		
	SECURED PARTY:	  	COMERICA BANK

 EXHIBIT A 
 COLLATERAL DESCRIPTION ATTACHMENT 
 TO UCC NATIONAL FORM FINANCING STATEMENT 
 All personal property of Borrower (herein referred to as “Borrower” or “Debtor”) whether presently existing or hereafter created or
acquired, and wherever located, including, but not limited to: 
 (a) all accounts (including health-care-insurance
receivables), chattel paper (including tangible and electronic chattel paper), deposit accounts, documents (including negotiable documents), equipment (including all accessions and additions thereto), general intangibles (including payment
intangibles and software), goods (including fixtures), instruments (including promissory notes), inventory (including all goods held for sale or lease or to be furnished under a contract of service, and including returns and repossessions),
investment property (including securities and securities entitlements), letter of credit rights, money, and all of Debtor’s books and records with respect to any of the foregoing, and the computers and equipment containing said books and
records; and 
 (b) any and all cash proceeds and/or noncash proceeds of any of the foregoing, including, without limitation,
insurance proceeds, and all supporting obligations and the security therefor or for any right to payment. All terms above have the meanings given to them in the California Uniform Commercial Code, as amended or supplemented from time to time,
including revised Division 9 of the Uniform Commercial Code-Secured Transactions, added by Stats. 1999, c.991 (S.B. 45), Section 35, operative July 1, 2001. 
 Notwithstanding the foregoing, the Collateral shall not include any copyrights, patents, trademarks, servicemarks and applications therefor, now owned or hereafter acquired, or any claims for damages by way of any
past, present and future infringement of any of the foregoing (collectively, the “Intellectual Property”); provided, however, that the Collateral shall include all accounts and general intangibles that consist of rights to payment and
proceeds from the sale, licensing or disposition of all or any part, or rights in, the foregoing (the “Rights to Payment”). Notwithstanding the foregoing, if a judicial authority (including a U.S. Bankruptcy Court) holds that a security
interest in the underlying Intellectual Property is necessary to have a security interest in the Rights to Payment, then the Collateral shall automatically, and effective as of June 11, 2008, include the Intellectual Property to the extent
necessary to permit perfection of Bank’s security interest in the Rights to Payment.Third Party Security Agreement

 Exhibit 10.2 
 THIRD PARTY 
 SECURITY AGREEMENT 
 This Third Party Security Agreement (this “Agreement”) is made and entered into as of June 11, 2008 by and between the undersigned
(“Grantor”), and COMERICA BANK (the “Bank”). 
 RECITALS 
 Bank proposes to enter into a transaction with TPTX, INC. (“Borrower”), which is an affiliate of Grantor, pursuant to a Loan and Security
Agreement dated as of June 11, 2008, as amended from time to time (the “Loan Agreement”). Grantor expects to derive economic benefit from Bank’s doing so and dealing with Borrower in accordance with the Loan Agreement, and
has entered into an Unconditional Guaranty of even date herewith with respect to the present and future obligations of Borrower to Bank (as amended from time to time, the “Guaranty”). Grantor wishes to secure performance and payment
of all obligations to Bank under the Guaranty (the “Guarantor Obligations”) with substantially all of its assets. All terms used without definition in this Agreement shall have the meaning assigned to them in the Loan Agreement. All
terms used without definition in this Agreement or in the Loan Agreement shall have the meaning assigned to them in the Uniform Commercial Code. 
 NOW, THEREFORE, Grantor and the Bank agree as follows: 
 1. Grant of Security Interest. To secure all of the
Guarantor Obligations, Grantor grants to the Bank a security interest in the property described in Exhibit A (the “Collateral”). 
 2. Grantor’s Representations and Warranties. Grantor represents and warrants as follows: 
 (a) Authorization. Grantor has authority and has obtained all approvals and consents necessary to enter into this Agreement, and Grantor’s execution, delivery and performance of this Agreement will not violate or conflict with
the terms of Grantor’s Certificate of Incorporation, Bylaws or other charter document, or any law, agreement, or other instrument or writing to which Grantor is party or by which is it bound. 
 (b) Title. The Collateral is owned by Grantor and is free of all liens, encumbrances and other security interests, except for
Permitted Liens. 
 (c) Solvency, Payment of Debts. Grantor, on a consolidated basis with its Subsidiaries, is able to
pay its debts (including trade debts) as they mature; the fair saleable value of Grantor’s and its Subsidiaries’ consolidated assets (including goodwill minus disposition costs) exceeds the fair value of their liabilities; and Grantor, on
a consolidated basis with its Subsidiaries, is not left with unreasonably small capital after the transactions contemplated by this Agreement. 
 (d) Further Representations. Grantor further represents, warrants, and covenants that (i) neither Grantor nor any Subsidiary is in default under any material agreement under which Grantor or such
Subsidiary owes any money, or any agreement, the violation or termination of which could reasonably be expected to have a material adverse effect on Grantor on a consolidated or consolidating basis; (ii) the information provided to Bank on or
prior to the date of this Agreement is true and correct in all material respects; (iii) all financial statements and other information provided to Bank fairly present Grantor’s financial condition, and there has not been a material adverse
change in the financial condition of Grantor since the date of the most recent of the financial statements submitted to Bank; (iv) Grantor and each Subsidiary is in compliance with all laws and orders applicable to it, except where the failure
to comply is not reasonably likely to have a Material Adverse Effect; (v) except as disclosed in the Schedule to the Loan Agreement, neither Grantor nor any Subsidiary is a party to any litigation or is the subject of any government
investigation, and neither Grantor nor any Subsidiary has any knowledge of any pending litigation or investigation or the existence of circumstances that reasonably could be expected to give rise to such litigation or investigation in which a likely
adverse decision could reasonably be expected to have a Material Adverse Effect; (vi) Grantor’s principal place of business is located at the address specified in Section 11; and (vii) no representation or other statement made by
Grantor to Bank contains any untrue statement of a material fact or omits to state a material fact necessary to make any statements made to Bank not misleading. 
  

 1 

 3. Covenants. 
 (a) Encumbrances. Except with respect to Permitted Liens, Grantor shall not grant a security interest in any of the Collateral
other than to Bank or execute any financing statements covering any of the Collateral in favor of any person other than Bank. 
 (b) Use of Collateral. The Collateral will not be used for any unlawful purpose or in any way that will void any insurance required to be carried in connection therewith. Grantor will keep the Collateral free and clear of liens and
adverse claims (other than Permitted Liens) and, as appropriate and applicable, will keep it in good condition and repair, normal wear and tear excepted, and will clean, shelter, and otherwise care for the Collateral in all such ways as are
considered good practice by owners of like property. 
 (c) Indemnification. Grantor shall indemnify Bank against all
losses, claims, demands and liabilities of any kind caused by the Collateral, except to the extent such losses, claims, demands and liabilities are caused by Bank’s gross negligence or willful misconduct. 
 (d) Perfection of Security Interest. Grantor shall execute and deliver such documents as Bank reasonably deems necessary to create,
perfect and continue the security interest in the Collateral contemplated hereby. Grantor shall deliver to Bank the share certificate(s) evidencing all of the shares of capital stock of Borrower, together with a stock power in a form acceptable to
Bank. 
 (e) Insurance of Collateral. 
 (i) Grantor, at its expense, shall keep the Collateral insured against loss or damage by fire, theft, explosion, sprinklers, and all other
hazards and risks, and in such amounts, as ordinarily insured against by other owners in similar businesses conducted in the locations where Grantor’s business is conducted on the date hereof. Grantor shall also maintain insurance relating to
Grantor’s ownership and use of the Collateral in amounts and of a type that are customary to businesses similar to Grantor’s. 
 (ii) All such policies of insurance shall be in such form, with such companies, and in such amounts as reasonably satisfactory to Bank. All such policies of property insurance shall contain a Bank’s loss payable
endorsement, in a form reasonably satisfactory to Bank, showing Bank as an additional loss payee thereof and all liability insurance policies shall show Bank as an additional insured, and shall specify that the insurer must give at least twenty
(20) days notice to Bank before canceling its policy for any reason. Upon Bank’s request, Grantor shall deliver to Bank certificates of such policies of insurance and evidence of the payments of all premiums therefor. All proceeds payable
under any such policy shall, at the option of Bank, be payable to Bank to be applied on account of the Guarantor Obligations. 
 (f) Inventory and Equipment. 
 (i) Except for mobile personal property, including laptop computers, having an
aggregate book value of not more than One Hundred Thousand Dollars ($100,000), Grantor shall not store its Inventory or the Equipment with a bailee, warehouseman, or other third party unless the third party has been notified of Bank’s security
interest and Bank (a) has received an acknowledgment from the third party that it is holding or will hold the Inventory or Equipment for Bank’s benefit or (b) is in pledge possession of the warehouse receipt, where negotiable,
covering such Inventory or Equipment. Except for the mobile personal property described in the preceding sentence, Grantor shall not store or maintain any Equipment or Inventory at a location other than the location set forth in Section 11 of
this Agreement. 
 (ii) Grantor shall maintain the Collateral in good and saleable condition, repair it if necessary and
otherwise deal with the Collateral in all such ways as are considered good practice by owners of like property, use it lawfully and only as permitted by insurance policies, and permit Bank to inspect the Collateral at any reasonable time.

  

 2 

 (iii) Not sell, contract to sell, lease, encumber or transfer the Collateral (other than
Permitted Transfers or Permitted Liens) until the Obligations and the Guarantor Obligations have been paid or performed in full, even though Bank has a security interest in the proceeds of such Collateral. 
 (g) Binding Agreement. Anything herein to the contrary notwithstanding, (a) Grantor shall remain liable under the contracts
and agreements included in the Collateral to the extent set forth therein to perform all of its duties and obligations thereunder to the same extent as if this Agreement had not been executed; (b) the exercise by Bank of any of the rights
granted hereunder shall not release Grantor from any of its duties or obligations under the contracts and agreements included in the Collateral; and (c) Bank shall not have any obligation or liability under the contracts and agreements included
in the Collateral by reason of this Agreement, nor shall Bank be obligated to perform any of the obligations or duties of Grantor thereunder or to take any action to collect or enforce any claim for payment assigned hereunder. 
 (h) Instruments. Grantor will deliver and pledge to Bank all Instruments that are part of the Collateral duly endorsed and
accompanied by duly executed instruments of transfer or assignment, all in form and substance reasonably satisfactory to Bank. 
 (i) Records. Grantor shall prepare and keep, in accordance with generally accepted accounting principles consistently applied, complete and accurate records regarding the Collateral and, if and when requested by Bank, shall prepare
and deliver a complete and accurate schedule of all the Collateral in such detail as Bank may reasonably require. 
 (j)
Inspection of Grantor’s Books. Grantor shall permit Bank or its designee at reasonable times during Grantor’s usual business hours but no more than once a year (unless an Event of Default has occurred and is continuing) and from
time to time to inspect Grantor’s books, records and properties and to audit and to make copies of extracts from such books and records. 
 (k) Fees and Costs. Grantor shall pay all expenses, including reasonable attorneys’ fees, incurred by Bank in the preservation, realization, enforcement or exercise of any Bank’s rights under this
Agreement. 
 (l) Accounts. Grantor shall maintain its primary depository, operating, and investment accounts with Bank
and/or Comerica Securities, Inc. 
 (m) Corporate Existence. Grantor will maintain its corporate existence and good
standing in its jurisdiction of formation and will maintain in force all material licenses and agreements, the loss of which could reasonably be expected to have a material adverse effect on Grantor’s business. Grantor will pay all material
taxes on or before the date such taxes are due, and will comply with all laws and orders applicable to it, provided that Grantor need not make any payment if the amount or validity of such payment is contested in good faith by appropriate
proceedings and is reserved against (to the extent required by GAAP) by Grantor. 
 (n) Negative Covenants. Grantor
will not (i) make any investments in, or loans or advances to, any person other than in the ordinary course of business as currently conducted other than Permitted Investments or as permitted under Section 7.7 of the Loan Agreement,
(ii) acquire any assets other than in the ordinary course of business as currently conducted or as permitted under Section 7.3 of the Loan Agreement, (iii) make any distributions or pay any dividends to any person on account of
Grantor’s shares, except that Grantor may (a) pay dividends in capital stock, (b) repurchase the stock of employees, officers or directors pursuant to stock repurchase agreements or stock purchase plans as long as an Event of Default
does not exist prior to such repurchase or would not exist after giving effect to such repurchase, (c) repurchase the stock of employees, officers or directors pursuant to stock repurchase agreements or stock purchase plans by the cancellation
of indebtedness owed by such former employees to Grantor regardless of whether an Event of Default exists, (d) convert any of its convertible securities (including warrants) into other securities pursuant to the terms of such convertible
securities and (e) distribute securities to employees, officers or directors on the exercise of their options, (iv) create, incur, assume or be or remain liable with respect to any Indebtedness other than Permitted Indebtedness,
(v) move, dispose of or encumber any portion of its assets, other than Permitted Transfers, (vi) merge or consolidate with or into any person or entity (other than mergers or consolidations of a Subsidiary into another Subsidiary or into
Borrower, and other than Permitted Investments or as permitted under Section 7.3 of 

  

 3 

 
the Loan Agreement), (vii) create, incur, assume or suffer to exist any lien with respect to any of its property other than Permitted Liens, or assign
or otherwise convey any right to receive income, including the sale of any of Grantor’s accounts, (viii) keep Inventory or Equipment at a location other than the address specified in Section 11 hereof except as set forth in
Section 3(f) hereof; (ix) relocate its chief executive office or state of incorporation without thirty days prior written notification to Bank, (x) or maintain or invest any of its property with a Person, other than Permitted
Investments, or other than Bank unless such Person has entered into an account control agreement with Bank in form and substance reasonably satisfactory to Bank, or suffer or permit any Subsidiary to be a party to, or be bound by, an agreement that
restricts such Subsidiary from paying dividends or otherwise distributing property to Grantor, or (xi) permit the inclusion in any contract to which it becomes a party of any provisions that restricts or invalidates the creation of a security
interest in any of Grantor’s property. 
 (o) Further Assurances. At any time and from time to time, upon the
written request of Bank, and at the sole expense of Grantor, Grantor shall promptly and duly execute and deliver any and all such further instruments and documents and take such further action as Bank may reasonably deem desirable to obtain the full
benefits of this Agreement and of the rights and powers herein granted, including, without limitation, (a) to secure all consents and approvals necessary or appropriate for the grant of a security interest to Bank in any Collateral held by
Grantor or in which Grantor has any rights not heretofore assigned, (b) filing any financing or continuation statements under the UCC with respect to the security interests granted hereby, (c) transferring Collateral to Bank’s
possession (if a security interest in such Collateral can be perfected by possession), (d) placing the interest of Bank as lienholder on the certificate of title (or other evidence of ownership) of any vehicle owned by Grantor or in or with
respect to which Grantor holds a beneficial interest and (e) using its best efforts to obtain waivers of liens from landlords and mortgagees. Grantor also hereby authorizes Bank to file any such financing or continuation statement without the
signature of Grantor. If any amount payable under or in connection with any of the Collateral is or shall become evidenced by any Instrument, such Instrument, other than checks and notes received in the ordinary course of business, shall be duly
endorsed in a manner satisfactory to Bank and delivered to Bank promptly upon Grantor’s receipt thereof. 
 4. Events of Default.
The occurrence of any Event of Default under the Loan Agreement, or the failure by Grantor to perform any obligations under the Guaranty, or the breach of any representation under this Agreement, or the failure to perform any obligation under
Section 3 of this Agreement, shall constitute an “Event of Default” under this Agreement. 
 5. Remedies on
Default. Upon the occurrence of an Event of Default, Bank shall have all rights, privileges, powers and remedies provided by law, including, but not limited to, exercise of any or all of the following remedies. 
 (a) Bank may declare all amounts outstanding under the Loan Agreement and the Guaranty to be immediately due and payable, and thereupon
all such amounts shall be and become immediately due and payable to the Bank. 
 (b) Bank may dispose of the Collateral in
accordance with applicable law. 
 (c) Bank may use, operate, consume and sell the Collateral in its possession as appropriate
for the purpose of performing Grantor’s obligations with respect thereto to the extent necessary to satisfy the obligations of Grantor. 
 (d) All payments received and amounts realized by Bank shall be promptly applied and distributed by the Bank in the following order of priority: 
 (i) first, to the payment of all costs and expenses, including reasonable legal expenses and attorneys fees, incurred or made hereunder by
Bank, including any such costs and expenses of foreclosure or suit, if any, and of any sale or the exercise of any other remedy under this Section 5, and of all taxes, assessments or liens superior to the lien granted under this Agreement; and

  

 4 

 (ii) second, to the payment to Bank of the amount then owing under the Loan Agreement.

 6. Power of Attorney. Grantor hereby appoints Bank, its attorney-in-fact to prepare, sign and file or record, for Grantor in
Grantor’s name, any financing statements, applications for registration and like papers and to take any other action deemed by Bank necessary or desirable in order to perfect the security interest of the Bank hereunder, to dispose of any
Collateral, and to perform any obligations of Grantor hereunder, at Grantor’s expense, but without obligation to do so. 
 7.
Remedies Cumulative. Bank’s rights and remedies under this Agreement, the Loan Documents, and all other agreements shall be cumulative. Bank shall have all other rights and remedies not inconsistent herewith as provided under the
California Uniform Commercial Code (the “UCC”), by law, or in equity. No exercise by Bank of one right or remedy shall be deemed an election, and no waiver by Bank of any Event of Default on Borrower’s or Grantor’s part shall be
deemed a continuing waiver. No delay by Bank shall constitute a waiver, election, or acquiescence by it. No waiver by Bank shall be effective unless made in a written document signed on behalf of Bank and then shall be effective only in the specific
instance and for the specific purpose for which it was given. 
 8. Amendment of Loan Documents. Grantor authorizes Bank, without
notice or demand and without affecting its liability hereunder, from time to time to (a) renew, extend, or otherwise change the terms of any Loan Document, or any part thereof; (b) take and hold security for the payment of any Loan
Document, and exchange, enforce, waive and release any such security; and (c) apply such security and direct the order or manner of sale thereof as Bank in its sole discretion may determine. 
 9. Grantor Waivers. Grantor waives any right to require Bank to (a) proceed against Borrower, any other guarantor or any other person;
(b) proceed against or exhaust any security held from Borrower; (c) marshal any assets of Borrower; or (d) pursue any other remedy in Bank’s power whatsoever. Bank may, at its election, exercise or decline or fail to exercise any
right or remedy it may have against Borrower or any security held by Bank, including without limitation the right to foreclose upon any such security by judicial or nonjudicial sale, without affecting or impairing in any way the liability of Grantor
hereunder. Grantor waives any defense arising by reason of any disability or other defense of Borrower or by reason of the cessation from any cause whatsoever of the liability of Borrower. Grantor waives any setoff, defense or counterclaim that
Borrower may have against Bank. Grantor waives any defense arising out of the absence, impairment or loss of any right of reimbursement or subrogation or any other rights against Borrower. Until all obligations under the Guaranty have been
satisfied, Grantor shall have no right of subrogation or reimbursement, contribution or other rights against Borrower, and Grantor waives any right to enforce any remedy that Bank now has or may hereafter have against Borrower. Grantor waives all
rights to participate in any security now or hereafter held by Bank. Grantor waives all presentments, demands for performance, notices of nonperformance, protests, notices of protest, notices of dishonor, and notices of acceptance of this Agreement
and of the existence, creation, or incurring of new or additional indebtedness. Grantor assumes the responsibility for being and keeping itself informed of the financial condition of Borrower and of all other circumstances bearing upon the risk of
nonpayment of any indebtedness or nonperformance of any obligation of Borrower, warrants to Bank that it will keep so informed, and agrees that absent a request for particular information by Grantor, Bank shall have no duty to advise Grantor of
information known to Bank regarding such condition or any such circumstances. Grantor waives the benefits of California Civil Code sections 2809, 2810, 2819, 2845, 2847, 2848, 2849, 2850, 2899 and 3433. 
 10. Borrower Insolvency. If Borrower becomes insolvent or is adjudicated bankrupt or files a petition for reorganization, arrangement, composition
or similar relief under any present or future provision of the United States Bankruptcy Code, or if such a petition is filed against Borrower, and in any such proceeding some or all of any indebtedness or obligations under the Loan Documents are
terminated or rejected or any obligation of Borrower is modified or abrogated, or if Borrower’s obligations are otherwise avoided for insolvency, bankruptcy or any similar reason, Grantor agrees that Grantor’s liability hereunder shall not
thereby be affected or modified and such liability shall continue in full force and effect as if no such action or proceeding had occurred. This Agreement shall continue to be effective or be reinstated, as the case may be, if any payment must be
returned by Bank upon the insolvency, bankruptcy or reorganization of Borrower, Grantor, any other person, or otherwise, as though such payment had not been made. 
  

 5 

 11. Notices. Unless otherwise provided in this Agreement, all notices or demands by any party
relating to this Agreement or any other agreement entered into in connection herewith shall be in writing and (except for financial statements and other informational documents which may be sent by first-class mail, postage prepaid) shall be
personally delivered or sent by a recognized overnight delivery service, certified mail, postage prepaid, return receipt requested, or by telefacsimile to Grantor or to Bank, as the case may be, at its addresses set forth below: 
  

			
	If to Grantor:	  	TORREYPINES THERAPEUTICS, INC.
		  	11085 N. Torrey Pines Road, Suite 300
		  	La Jolla, California 92037
		  	Attn: Chief Financial Officer
		  	Fax: (858) 623-5666
		
	If to Bank:	  	Comerica Bank
		  	75 East Trimble Road, M/C 4770
		  	San Jose, California 95131
		  	Attn: Manager
		  	FAX: (408) 556-5091
		
	with a copy to:	  	Comerica Bank
		  	11943 El Camino Real, Suite 110B
		  	San Diego, California 92130
		  	Attn: Greg Park
		  	Fax: (858) 509-2365

 The parties hereto may change the address at which they are to receive notices hereunder, by
notice in writing in the foregoing manner given to the other. 
 12. Choice of Law and Venue; Jury Trial Waiver. 
 This Agreement shall be governed by, and construed in accordance with, the internal laws of the State of California, without regard to principles of
conflicts of law. Each of Borrower and Bank hereby submits to the exclusive jurisdiction of the state and Federal courts located in the County of Santa Clara, State of California. THE UNDERSIGNED ACKNOWLEDGE THAT THE RIGHT TO TRIAL BY JURY IS A
CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED UNDER CERTAIN CIRCUMSTANCES. TO THE EXTENT PERMITTED BY LAW, EACH PARTY, AFTER CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF ITS, HIS OR HER CHOICE, KNOWINGLY AND VOLUNTARILY, AND
FOR THE MUTUAL BENEFIT OF ALL PARTIES, WAIVES ANY RIGHT TO TRIAL BY JURY IN THE EVENT OF LITIGATION ARISING OUT OF OR RELATED TO THIS AGREEMENT OR ANY OTHER DOCUMENT, INSTRUMENT OR AGREEMENT BETWEEN THE UNDERSIGNED PARTIES. 
 13. Reference Provision. 
 In the
event the Jury Trial Waiver set forth above is not enforceable, the parties elect to proceed under this Judicial Reference Provision. 
 13.1 Mechanics. 
 (a) With the exception of the items specified in clause (c), below,
any controversy, dispute or claim (each, a “Claim”) between the parties arising out of or relating to this Agreement or any other document, instrument or agreement between the undersigned parties (collectively in this Section, the
“Comerica Documents”), will be resolved by a reference proceeding in California in accordance with the provisions of Sections 638 et seq. of the California Code of Civil Procedure (“CCP”), or their successor sections, which shall
constitute the exclusive remedy for the resolution of any Claim, including whether the Claim is subject to the reference proceeding. Except as otherwise provided in the Comerica Documents, venue for the reference proceeding will be in the state or
federal court in the county or district where the real property involved in the action, if any, is located or in the state or federal court in the county or district where venue is otherwise appropriate under applicable law (the “Court”).

  

 6 

 (b) The matters that shall not be subject to a reference are the following:
(i) nonjudicial foreclosure of any security interests in real or personal property, (ii) exercise of self-help remedies (including, without limitation, set-off), (iii) appointment of a receiver and (iv) temporary, provisional or
ancillary remedies (including, without limitation, writs of attachment, writs of possession, temporary restraining orders or preliminary injunctions). This reference provision does not limit the right of any party to exercise or oppose any of the
rights and remedies described in clauses (i) and (ii) or to seek or oppose from a court of competent jurisdiction any of the items described in clauses (iii) and (iv). The exercise of, or opposition to, any of those items does not
waive the right of any party to a reference pursuant to this reference provision as provided herein. 
 (c) The referee shall
be a retired judge or justice selected by mutual written agreement of the parties. If the parties do not agree within ten (10) days of a written request to do so by any party, then, upon request of any party, the referee shall be selected by
the Presiding Judge of the Court (or his or her representative). A request for appointment of a referee may be heard on an ex parte or expedited basis, and the parties agree that irreparable harm would result if ex parte relief is not granted.
Pursuant to CCP § 170.6, each party shall have one peremptory challenge to the referee selected by the Presiding Judge of the Court (or his or her representative). 
 (d) The parties agree that time is of the essence in conducting the reference proceedings. Accordingly, the referee shall be requested,
subject to change in the time periods specified herein for good cause shown, to (i) set the matter for a status and trial-setting conference within fifteen (15) days after the date of selection of the referee, (ii) if practicable, try
all issues of law or fact within one hundred twenty (120) days after the date of the conference and (iii) report a statement of decision within twenty (20) days after the matter has been submitted for decision. 
 (e) The referee will have power to expand or limit the amount and duration of discovery. The referee may set or extend discovery deadlines
or cutoffs for good cause, including a party’s failure to provide requested discovery for any reason whatsoever. Unless otherwise ordered based upon good cause shown, no party shall be entitled to “priority” in conducting discovery,
depositions may be taken by either party upon seven (7) days written notice, and all other discovery shall be responded to within fifteen (15) days after service. All disputes relating to discovery which cannot be resolved by the parties
shall be submitted to the referee whose decision shall be final and binding. 
 13.2 Procedures. Except as expressly
set forth herein, the referee shall determine the manner in which the reference proceeding is conducted including the time and place of hearings, the order of presentation of evidence, and all other questions that arise with respect to the course of
the reference proceeding. All proceedings and hearings conducted before the referee, except for trial, shall be conducted without a court reporter, except that when any party so requests, a court reporter will be used at any hearing conducted before
the referee, and the referee will be provided a courtesy copy of the transcript. The party making such a request shall have the obligation to arrange for and pay the court reporter. Subject to the referee’s power to award costs to the
prevailing party, the parties will equally share the cost of the referee and the court reporter at trial. 
 13.3
Application of Law. The referee shall be required to determine all issues in accordance with existing case law and the statutory laws of the State of California. The rules of evidence applicable to proceedings at law in the State of
California will be applicable to the reference proceeding. The referee shall be empowered to enter equitable as well as legal relief, enter equitable orders that will be binding on the parties and rule on any motion which would be authorized in a
court proceeding, including without limitation motions for summary judgment or summary adjudication. The referee shall issue a decision at the close of the reference proceeding which disposes of all claims of the parties that are the subject of the
reference. Pursuant to CCP § 644, such decision shall be entered by the Court as a judgment or an order in the same manner as if the action had been tried by the Court and any such decision will be final, binding and conclusive. The parties
reserve the right to appeal from the final judgment or order or from any appealable decision or order entered by the referee. The parties reserve the right to findings of fact, conclusions of laws, a written statement of decision, and the right to
move for a new trial or a different judgment, which new trial, if granted, is also to be a reference proceeding under this provision. 
  

 7 

 13.4 Repeal. If the enabling legislation which provides for appointment of a
referee is repealed (and no successor statute is enacted), any dispute between the parties that would otherwise be determined by reference procedure will be resolved and determined by arbitration. The arbitration will be conducted by a retired judge
or justice, in accordance with the California Arbitration Act §1280 through §1294.2 of the CCP as amended from time to time. The limitations with respect to discovery set forth above shall apply to any such arbitration proceeding.

 13.5 THE PARTIES RECOGNIZE AND AGREE THAT ALL CONTROVERSIES, DISPUTES AND CLAIMS RESOLVED UNDER THIS REFERENCE PROVISION
WILL BE DECIDED BY A REFEREE AND NOT BY A JURY. AFTER CONSULTING (OR HAVING HAD THE OPPORTUNITY TO CONSULT) WITH COUNSEL OF ITS, HIS OR HER OWN CHOICE, EACH PARTY KNOWINGLY AND VOLUNTARILY, AND FOR THE MUTUAL BENEFIT OF ALL PARTIES, AGREES THAT THIS
REFERENCE PROVISION WILL APPLY TO ANY CONTROVERSY, DISPUTE OR CLAIM BETWEEN OR AMONG THEM ARISING OUT OF OR IN ANY WAY RELATED TO, THIS AGREEMENT OR THE OTHER COMERICA DOCUMENTS. 
 14. General Provisions. 
 14.1 Successors and Assigns. This Agreement shall bind and inure to the benefit of the respective successors and permitted assigns of each of the parties; provided, however, that neither this Agreement nor any rights hereunder may be
assigned by Grantor without Bank’s prior written consent, which consent may be granted or withheld in Bank’s sole discretion. Bank shall have the right without the consent of or notice to Grantor to sell, transfer, negotiate, or grant
participation in all or any part of, or any interest in, Bank’s obligations, rights and benefits hereunder. 
 14.2
Indemnification. Grantor shall defend, indemnify and hold harmless Bank and its officers, employees, and agents against: (a) all obligations, demands, claims, and liabilities claimed or asserted by any other party in connection with the
transactions contemplated by this Agreement; and (b) all losses or Bank Expenses in any way suffered, incurred, or paid by Bank as a result of or in any way arising out of, following, or consequential to transactions between Bank and Grantor
whether under this Agreement, or otherwise (including without limitation reasonable attorneys’ fees and expenses), except for losses caused by Bank’s gross negligence or willful misconduct. 
 14.3 Time of Essence. Time is of the essence for the performance of all obligations set forth in this Agreement. 
 14.4 Severability of Provisions. Each provision of this Agreement shall be severable from every other provision of this Agreement
for the purpose of determining the legal enforceability of any specific provision. 
 14.5 Amendments in Writing,
Integration. This Agreement cannot be amended or terminated orally. All prior agreements, understandings, representations, warranties, and negotiations between the parties hereto with respect to the subject matter of this Agreement, if any, are
merged into this Agreement and the Loan Documents. 
 14.6 Counterparts. This Agreement may be executed in any number
of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, shall be deemed to be an original, and all of which, when taken together, shall constitute but one and the same Agreement. 
 14.7 Survival. All covenants, representations and warranties made in this Agreement shall continue in full force and effect so long
as any Obligations remain outstanding, any Guarantor Obligations remain outstanding, or Bank has any obligation to make Credit Extensions to Borrower. The obligations of Grantor to indemnify Bank with respect to the expenses, damages, losses, costs
and liabilities described in Section 14.2 shall survive until all applicable statute of limitations periods with respect to actions that may be brought against Bank have run. 
  

 8 

 IN WITNESS WHEREOF, the parties have executed this Agreement on the date set forth above. 
  

									
	GRANTOR:	 		 	BANK:
	TORREYPINES THERAPEUTICS, INC.	 		 	COMERICA BANK
					
	By:	 	/s/ Craig A. Johnson	 		 	By:	 	/s/ Greg Park
	Name:	 	Craig A. Johnson	 		 	Name: 	 	 Greg Park

	Title:	 	Vice President and Chief Financial Officer	 		 	Title:	 	 Vice President

 [Signature Page to Third Party Security Agreement] 
  

 9 

			
	DEBTOR:	  	TORREYPINES THERAPEUTICS, INC.
		
	SECURED PARTY:	  	COMERICA BANK

 EXHIBIT A 
 COLLATERAL DESCRIPTION ATTACHMENT 
 TO THIRD PARTY SECURITY AGREEMENT 
 All personal property of Grantor (herein referred to as “Grantor” or “Debtor”) whether presently existing or hereafter created or
acquired, and wherever located, including, but not limited to: 
 (a) all accounts (including health-care-insurance
receivables), chattel paper (including tangible and electronic chattel paper), deposit accounts, documents (including negotiable documents), equipment (including all accessions and additions thereto), general intangibles (including payment
intangibles and software), goods (including fixtures), instruments (including promissory notes), inventory (including all goods held for sale or lease or to be furnished under a contract of service, and including returns and repossessions),
investment property (including securities and securities entitlements), letter of credit rights, money, and all of Debtor’s books and records with respect to any of the foregoing, and the computers and equipment containing said books and
records; and 
 (b) any and all cash proceeds and/or noncash proceeds of any of the foregoing, including, without limitation,
insurance proceeds, and all supporting obligations and the security therefor or for any right to payment. 
 All terms above have the
meanings given to them in the California Uniform Commercial Code, as amended or supplemented from time to time, including revised Division 9 of the Uniform Commercial Code-Secured Transactions, added by Stats. 1999, c.991 (S.B. 45), Section 35,
operative July 1, 2001. 
 Notwithstanding the foregoing, the Collateral shall not include any copyrights, patents, trademarks,
servicemarks and applications therefor, now owned or hereafter acquired, or any claims for damages by way of any past, present and future infringement of any of the foregoing (collectively, the “Intellectual Property”); provided, however,
that the Collateral shall include all accounts and general intangibles that consist of rights to payment and proceeds from the sale, licensing or disposition of all or any part, or rights in, the foregoing (the “Rights to Payment”).
Notwithstanding the foregoing, if a judicial authority (including a U.S. Bankruptcy Court) holds that a security interest in the underlying Intellectual Property is necessary to have a security interest in the Rights to Payment, then the Collateral
shall automatically, and effective as of June 11, 2008, include the Intellectual Property to the extent necessary to permit perfection of Bank’s security interest in the Rights to Payment. 

 

 
 Agreement to Furnish Insurance 
 (Herein called “Bank”) 
 Guarantor(s): TORREYPINES THERAPEUTICS, INC. 
 I understand that the Security Agreement or Deed of Trust which I executed in connection with this transaction requires me to provide a physical damage insurance policy
including a Lenders Loss Payable Endorsement in favor of the Bank as shown below, within ten (10) days from the date of this agreement. 
 The following
minimum insurance must be provided according to the terms of the security documents. 
  

							
	  ̈
	 	AUTOMOBILES, TRUCKS, RECREATIONAL VEHICLES	  	 ̈	  	MACHINERY & EQUIPMENT: MISCELLANEOUS PERSONAL PROPERTY
				
		 	 Comprehensive & Collision
	  		  	 Fire & Extended Coverage

		 	 Lender’s Loss Payable Endorsement
	  		  	 Lender’s Loss Payable Endorsement

		 		  		  	  ̈        Breach of Warranty Endorsement

	  ̈
	 	BOATS	  	 ̈	  	AIRCRAFT
		 	 All Risk Hull Insurance
	  		  	 All Risk Ground & Flight Insurance

		 	 Lender’s Loss Payable Endorsement
	  		  	 Lender’s Loss Payable Endorsement

		 	  ̈        Breach of Warranty Endorsement
	  		  	  ̈        Breach of Warranty Endorsement

	  ̈
	 	MOBILE HOMES	  	 ̈	  	REAL PROPERTY
		 	 Fire, Theft & Combined Additional Coverage
	  		  	 Fire & Extended Coverage

		 	 Lender’s Loss Payable Endorsement
	  		  	 Lender’s Loss Payable Endorsement

		 	  ̈        Earthquake
	  		  	  ̈        All Risk Coverage

		 		  		  	  ̈        Special Form Risk Coverage

		 		  		  	  ̈        

		 		  		  	  ̈        Earthquake

	  ̈
	 	INVENTORY	  		  	  ̈        Other
_____________________________

		
	  ̈
	 	Other _______________________________________________________________________________________________
		 	            _______________________________________________________________________________________________
		
		 	            _______________________________________________________________________________________________

 I may obtain the required insurance from any company that is acceptable to the Bank, and will deliver proof of such
coverage with an effective date of June 11, 2008 or earlier. 
 I understand and agree that if I fail to deliver proof of insurance to the Bank at the
address below, or upon the lapse or cancellation of such insurance, the Bank may procure Lender’s Single Interest Insurance or other similar coverage on the property. If the Bank procures insurance to protect its interest in the property
described in the security documents, the cost for the insurance will be added to my indebtedness as provided in the security documents. Lender’s Single Interest Insurance shall cover only the Bank’s interest as a secured party, and shall
become effective at the earlier of the funding date of this transaction or the date my insurance was canceled or expired. I UNDERSTAND THAT LENDER’S SINGLE INTEREST INSURANCE WILL PROVIDE ME WITH ONLY LIMITED PROTECTION AGAINST PHYSICAL DAMAGE
TO THE COLLATERAL, UP TO THE BALANCE OF THE LOAN, HOWEVER, MY EQUITY IN THE PROPERTY WILL NOT BE INSURED. FURTHER, THE INSURANCE WILL NOT PROVIDE MINIMUM PUBLIC LIABILITY OR PROPERTY DAMAGE INDEMNIFICATION AND DOES NOT MEET THE REQUIREMENTS OF THE
FINANCIAL RESPONSIBILITY LAW. 
 CALIFORNIA CIVIL CODE SECTION 2955.5. HAZARD INSURANCE DISCLOSURE: No lender shall require a borrower, as a condition of
receiving or maintaining a loan secured by real property, to provide hazard insurance coverage against risks to the improvements on that real property in an amount exceeding the replacement value of the improvements on the property. 
  

	
	Bank Address for Insurance Documents:
	  
 Comerica Bank – Collateral Operations, Mail Code
4770

	75 East Trimble Road
	San Jose, California 95131

 I acknowledge having read the provisions of this agreement, and agree to its terms. I authorize the Bank to provide to
any person (including any insurance agent or company) any information necessary to obtain the insurance coverage required. 
  

					
	 OWNER(S) OF COLLATERAL:
 TORREYPINES THERAPEUTICS,
INC.
	 		 	DATED: June 11, 2008
			
	  	 		 	  
			
	  	 		 	  

  

					
	INSURANCE VERIFICATION	 		 	
			
	Date _________________________	 	Phone                                      
   	 	
	Agents Name _______________________________________	 	Person Talked To                      	 	
	Agents Address ______________________________________________________________________________________________
	Insurance Company ___________________________________________________________________________________________
	Policy Number(s) ____________________________________________________________________________________________
	Effective Dates: From _________________________________________	 	To: __________________________________________	 	
	Deductible $ ________________________________________________	 	Comments: ____________________________________	 	
		 		 	

			
	DEBTOR:	  	TORREYPINES THERAPEUTICS, INC.
		
	SECURED PARTY:	  	COMERICA BANK

 EXHIBIT A 
 COLLATERAL DESCRIPTION ATTACHMENT 
 TO UCC NATIONAL FORM FINANCING STATEMENT 
 All personal property of Grantor (herein referred to as “Grantor” or “Debtor”) whether presently existing or hereafter created or
acquired, and wherever located, including, but not limited to: 
 (a) all accounts (including health-care-insurance
receivables), chattel paper (including tangible and electronic chattel paper), deposit accounts, documents (including negotiable documents), equipment (including all accessions and additions thereto), general intangibles (including payment
intangibles and software), goods (including fixtures), instruments (including promissory notes), inventory (including all goods held for sale or lease or to be furnished under a contract of service, and including returns and repossessions),
investment property (including securities and securities entitlements), letter of credit rights, money, and all of Debtor’s books and records with respect to any of the foregoing, and the computers and equipment containing said books and
records; and 
 (b) any and all cash proceeds and/or noncash proceeds of any of the foregoing, including, without limitation,
insurance proceeds, and all supporting obligations and the security therefor or for any right to payment. 
 All terms above have the
meanings given to them in the California Uniform Commercial Code, as amended or supplemented from time to time, including revised Division 9 of the Uniform Commercial Code-Secured Transactions, added by Stats. 1999, c.991 (S.B. 45), Section 35,
operative July 1, 2001. 
 Notwithstanding the foregoing, the Collateral shall not include any copyrights, patents, trademarks,
servicemarks and applications therefor, now owned or hereafter acquired, or any claims for damages by way of any past, present and future infringement of any of the foregoing (collectively, the “Intellectual Property”); provided, however,
that the Collateral shall include all accounts and general intangibles that consist of rights to payment and proceeds from the sale, licensing or disposition of all or any part, or rights in, the foregoing (the “Rights to Payment”).
Notwithstanding the foregoing, if a judicial authority (including a U.S. Bankruptcy Court) holds that a security interest in the underlying Intellectual Property is necessary to have a security interest in the Rights to Payment, then the Collateral
shall automatically, and effective as of June 11, 2008, include the Intellectual Property to the extent necessary to permit perfection of Bank’s security interest in the Rights to Payment.

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