Document:

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                                                                   EXHIBIT 10.30

                       NOTE AND WARRANT PURCHASE AGREEMENT

        This NOTE AND WARRANT PURCHASE AGREEMENT, dated as of September 19, 2002
(as amended, modified or supplemented from time to time, this "AGREEMENT") is
entered into by and among ISTA Pharmaceuticals, Inc., a Delaware corporation
(the "COMPANY"), and the persons and entities listed on the Schedule of
Purchasers attached hereto as Schedule I (each a "PURCHASER", and collectively,
the "PURCHASERS").

                                    RECITALS

        A. On the terms and subject to the conditions set forth herein, each
Purchaser is severally willing to purchase from the Company, and the Company is
willing to sell to such Purchaser, a senior secured convertible promissory note
in the principal amount set forth opposite such Purchaser's name on Schedule I
hereto and a warrant to purchase that number of shares of common stock of the
Company set forth opposite such Purchaser's name on Schedule I hereto.

        B. Capitalized terms not otherwise defined herein shall have the meaning
set forth in the form of Note (as defined below) attached hereto as Exhibit A.

                                    AGREEMENT

        NOW THEREFORE, in consideration of the foregoing, and the
representations, warranties, and conditions set forth below, the parties hereto,
intending to be legally bound, hereby agree as follows:

        1. THE NOTES AND WARRANTS.

               (a) Issuance of Notes. At the Closing (as defined below), the
Company agrees to issue and sell to each of the Purchasers, and, subject to all
of the terms and conditions hereof, each of the Purchasers agrees to purchase a
(i) Senior Secured Convertible Promissory Note in the form of Exhibit A hereto
(each, as amended, modified or supplemented from time to time, a "NOTE", and
collectively, the "NOTES") in the principal amount set forth opposite the
respective Purchaser's name on Schedule I hereto; provided that the aggregate
principal amount of all Notes shall not exceed $4,000,000 (the "MAXIMUM LOAN
AMOUNT"); and (ii) a Warrant to Purchase Shares of Common Stock in the form of
Exhibit B hereto (each, as amended, modified or supplemented from time to time,
a "WARRANT" and collectively, the "WARRANTS") for such number of shares of
common stock, par value $0.001 per share, of the Company (the "COMMON STOCK")
set forth opposite the respective Purchaser's name on Schedule I hereto. The
obligations of the Purchasers to purchase Notes and Warrants are several and not
joint.

               (b) Delivery. The sale and purchase of the Notes and the Warrants
shall take place at a closing (the "CLOSING") to be held on September 19, 2002
(the "CLOSING DATE") at the

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offices of Wilson Sonsini Goodrich & Rosati, P.C., 650 Page Mill Road, Palo
Alto, California 94304. At the Closing, Company will deliver to each of the
Purchasers the respective Note and Warrant to be purchased by such Purchaser,
against receipt by the Company of the corresponding purchase price set forth on
Schedule I hereto (the "PURCHASE PRICE"). All Notes shall be issued in the same
form (with such changes as may be necessary to reflect the different Purchasers
and principal amounts) and shall rank pari passu among themselves. No Notes
shall be issued at a discount. Each of the Notes and the Warrants and will be
registered in such Purchaser's name in Company's records.

               (c) Use of Proceeds. The proceeds of the sale and issuance of the
Notes and the Warrants shall be used to fund clinical trials, for working
capital and for general corporate purposes. None of the proceeds will be used to
acquire "margin stock" (as defined in Regulation U of the Board of Governors of
the Federal Reserve System of the United States) or to finance the acquisition
of any Person or for any personal, family or household purposes.

               (d) Payments. The Company will make all cash payments due under
the Notes in immediately available funds by 11:00 A.M. San Francisco, California
time on the date such payment is due in the manner and at the address for such
purpose specified below each Purchaser's name on Schedule I hereto, or at such
other address as a Purchaser or other registered holder of a Note may from time
to time direct in writing.

        2. REPRESENTATIONS AND WARRANTIES OF THE COMPANY. The Company represents
and warrants to each Purchaser that:

        (a) Due Incorporation, Qualification, etc. The Company (i) is a
corporation duly organized, validly existing and in good standing under the laws
of its state of incorporation; (ii) has all requisite corporate power and
authority to own, lease and operate its properties and carry on its business as
now conducted; and (iii) is duly qualified or licensed to do business and in
good standing as a foreign corporation in each jurisdiction where the failure to
be so qualified or licensed could reasonably be expected to have a Material
Adverse Effect. Each of the Company's Subsidiaries (x) is a corporation duly
organized, validly existing and in good standing under the laws of its state of
incorporation; (y) has all requisite corporate power and authority to carry on
its business as it is now being conducted and to own the properties and assets
it now owns; and (z) is duly qualified or licensed to do business as a foreign
corporation in good standing in every jurisdiction in which such qualification
is required except where failure to be so qualified or licensed or in good
standing would not reasonably be expected to have a Material Adverse Effect.

        (b) Authority. The Company has all requisite corporate power and
authority to execute and deliver the Transaction Documents, to perform its
obligations under the Transaction Documents and to consummate the transactions
contemplated by the Transaction Documents. The execution and delivery of the
Transaction Documents by the Company and the performance by the Company of its
obligations under the Transaction Documents and the consummation by the Company
of the transactions contemplated by the Transaction Documents have been duly
authorized by the Company's Board of Directors and, except for obtaining
Stockholder Approval as contemplated by

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Section 8 of the Notes, no other corporate action on the part of the Company or
its stockholders is necessary to authorize the execution and delivery by the
Company of the Transaction Documents or the consummation by it of the
transactions contemplated by the Transaction Documents.

        (c) Enforceability. Each Transaction Document executed, or to be
executed, by the Company has been, or when executed will be, duly executed and
delivered by the Company and constitutes, or will when executed constitute, a
legal, valid and binding obligation of the Company, enforceable against the
Company in accordance with its terms, except as limited by bankruptcy,
insolvency, moratorium, reorganization or other laws of general application
relating to or affecting the enforcement of creditors' rights generally and
general principles of equity (regardless of whether enforcement is sought in
equity or at law).

        (d) Non-Contravention. The execution and delivery by the Company of the
Transaction Documents and the performance and consummation by the Company of the
transactions contemplated thereby will not (i) violate the certificate of
incorporation or by-laws of the Company or any judgment, order, writ, decree,
statute, rule or regulation applicable to the Company or any of its properties
or assets; (ii) result in a violation or breach of, or constitute (with or
without due notice or the passage of time or both) a default (or give rise to
any right of termination, amendment, cancellation, or acceleration or loss of
any rights) under, any of the terms, conditions or provisions of any material
agreement to which the Company is a party or any of its properties or assets is
bound; or (iii) result in the creation or imposition of any Lien upon any
property, asset or revenue of the Company (other than any Lien granted under the
Transaction Documents) or the suspension, revocation, impairment, forfeiture, or
non-renewal of any material permit, license, authorization or approval
applicable to the Company, its business or operations, or any of its assets or
properties.

        (e) Approvals. No consent, approval, permit, order or authorization of,
or registration, declaration or filing with, any Governmental Entity (as defined
below) or other Person (including, without limitation, the stockholders,
partners or members of any Person) is required in connection with the execution
and delivery of the Transaction Documents executed by the Company and the
performance and consummation of the transactions contemplated thereby, other
than filings in connection with the Liens granted under the Transaction
Documents, filings with certain federal and state securities commissions,
filings with the Nasdaq Stock Market and the approval of the stockholders of the
Company of the conversion provisions of the Notes.

        (f) Litigation. Except as disclosed in the Company SEC Documents, there
is no action, suit, inquiry, proceeding or investigation by or before any court,
arbitral tribunal, Regulatory Authority, administrative agency, commission or
other governmental or other regulatory authority or agency, or any Person
exercising the authority of any of the foregoing (a "GOVERNMENTAL ENTITY") or,
to the knowledge of the Company and its Subsidiaries, threatened against or
involving the Company or any of its Subsidiaries, or which questions or
challenges the validity of the Transaction Documents or any action taken or to
be taken by the Company or any of its Subsidiaries pursuant to the Transaction
Documents or in connection with the transactions contemplated thereby. Neither
the

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Company nor any of its Subsidiaries is in default under or in violation of, nor
to the knowledge of the Company and its Subsidiaries is there any valid basis
for any claim of default under or violation of, any Company Agreement. Neither
the Company nor any of its Subsidiaries is subject to any judgment, order or
decree that materially restricts its business practices or its ability to
acquire any property or conduct its business in any area.

        (g) Investment Company Act. The Company is not subject to regulation
under the Investment Company Act of 1940, as amended, the Public Utility Holding
Company Act of 1935, as amended, the Federal Power Act, as amended, any state
public utilities code or to any federal or state statute or regulation limiting
its ability to incur Indebtedness.

        (h) Valid Issuance of Equity Securities. The shares of Common Stock
issuable upon the conversion of the Notes or the exercise of the Warrants are
duly and validly reserved for issuance and when issued upon the conversion of
the Notes or the exercise of the Warrants in accordance with their respective
terms and for the consideration expressed therein, shall be duly and validly
issued, fully paid and nonassessable.

        (i) Event of Default. No Event of Default (as defined in the Notes), or
to the knowledge of the Company, any event that imminently will constitute an
Event of Default, has occurred and is continuing.

        (j) Reports and Financial Statements. (i) The Company has filed with the
SEC the Company SEC Documents. As of their respective dates (or, if amended or
superseded, as of the date of the last such amendment or superseding report
filed prior to the date of this Agreement), the Company SEC Documents, including
any financial statements or schedules included therein (a) did not contain any
untrue statement of a material fact or omit to state a material fact required to
be stated therein or necessary in order to make the statements made therein, in
the light of the circumstances under which they were made, not misleading and
(b) complied in all material respects with the applicable requirements of the
Exchange Act and the Securities Act, as the case may be, and the applicable
rules and regulations of the SEC thereunder. The Chief Executive Officer and the
Chief Financial Officer of the Company have signed, and the Company has
furnished to the SEC, all certifications required by Section 906 of the
Sarbanes-Oxley Act of 2002; such certifications contain no qualifications or
exceptions to the matters certified therein and have not been modified or
withdrawn; and neither the Company nor any of it officers has received notice
from any Governmental Entity questioning or challenging the accuracy,
completeness, form or manner of filing or submission of such certifications.
None of the Company's Subsidiaries is required to file any forms, reports or
other documents with the SEC.

        (ii) Each of the Financial Statements has been prepared from, and are in
accordance with, the books and records of the Company and its Subsidiaries. The
Financial Statements complied, as of their respective dates, in all material
respects with applicable accounting requirements and rules and regulations of
the SEC. The Financial Statements have been prepared in accordance with GAAP

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applied on a consistent basis (except as may be indicated in the notes thereto
and subject, in the case of interim condensed consolidated financial statements,
to normal, recurring and year-end adjustments which were not and are not
expected to be material in amount and the absence of certain notes) and fairly
present in all material respects as of their respective dates (i) the
consolidated financial position of the Company and its Subsidiaries as of the
dates thereof and (ii) the consolidated results of operations, changes in
stockholders equity and cash flows of the Company and its Subsidiaries for the
periods presented therein.

        (k) No Undisclosed Liabilities. Except (i) as disclosed in the Financial
Statements, (ii) for liabilities disclosed in the Company SEC Documents, and
(iii) for liabilities and obligations incurred in the ordinary course of
business and consistent with past practice since the Balance Sheet Date, and
except as set forth on the Company Disclosure Schedule, neither the Company nor
any of its Subsidiaries has any material liability or obligation of any nature,
whether or not accrued, contingent or otherwise that would be required by GAAP
to be disclosed on a consolidated balance sheet of the Company or in the notes
thereto. The Company has not created any entities or entered into any
transactions or created any liabilities or obligations of any nature, whether or
not accrued, contingent or otherwise, for the purpose of avoiding disclosure
required by GAAP.

        (l) No Material Adverse Effect. Since the Balance Sheet Date, there has
not been any Company Material Adverse Effect.

        (m) Common Stock Purchase Agreement. (i) The Company has all requisite
corporate power and authority to execute and deliver the Common Stock Purchase
Agreement and the warrants to be issued in connection with the Common Stock
Purchase Agreement (the "SPA WARRANTS"), to perform its obligations under the
Common Stock Purchase Agreement and the SPA Warrants and to consummate the
Transactions. The execution and delivery of the Common Stock Agreement by the
Company and the performance by the Company of its obligations under the Common
Stock Purchase Agreement and the consummation by the Company of the
Transactions, have been duly authorized by the Company's board of directors and,
except for obtaining Stockholder Approval (as defined in the Common Stock
Purchase Agreement) as contemplated by Section 7.4 of the Common Stock Purchase
Agreement, no other corporate action on the part of the Company or its
stockholders is necessary to authorize the execution and delivery by the Company
of the Common Stock Purchase Agreement or the SPA Warrants or the consummation
by it of the Transactions. The Common Stock Purchase Agreement has been and, as
of the closing under the Common Stock Purchase Agreement, the SPA Warrants, will
be duly executed and delivered by the Company and, the Common Stock Purchase
Agreement, assuming due and valid authorization, execution and delivery thereof
by the investors party thereto, is, and as of the closing under the Common Stock
Purchase Agreement, the SPA Warrants will be, valid and binding obligations of
the Company enforceable against the Company in accordance with their respective
terms.

        (ii) Except for the filings, permits, authorizations, consents, notices
and approvals as may be required under, and other applicable requirements of,
the Exchange Act, state securities or blue

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sky laws, none of the execution, delivery or performance of the Common Stock
Purchase Agreement by the Company, the consummation by the Company of the
transactions contemplated thereby or compliance by the Company with any of the
provisions of the Common Stock Agreement will (a) conflict with or result in any
breach of any provision of the certificate of incorporation, the by-laws or
similar organizational documents of the Company or any of its Subsidiaries, (b)
require any material filing with, or permit, authorization, consent or approval
of, any Governmental Entity, (c) result in a material violation or breach of, or
constitute (with or without due notice or the passage of time or both) a default
(or give rise to any right of termination, amendment, cancellation or
acceleration or loss of any rights) under, any of the terms, conditions or
provisions of any Company Agreement or (d) violate any order, writ, injunction,
decree, or any material statute, rule or regulation applicable to the Company,
any Company Subsidiary or any of their material properties or assets, in each
case except as set forth in the Company Disclosure Schedule.

        (n) Usury Exemption. Either (i) the Company and the Purchasers, or any
of their respective officers, directors or controlling persons, have a
preexisting personal or business relationship (as such terms are used in Section
25118 of the California Corporate Securities Law of 1968) or (ii) the Company
has by reason of its own business and financial experience or that of its
professional advisers, capacity to protect its own interests in connection with
the transactions (as such terms are used in Section 25118 of the California
Corporate Securities Law of 1968) contemplated by the Transaction Documents.

        3. REPRESENTATIONS AND WARRANTIES OF PURCHASERS. Each Purchaser,
severally and as to itself only, represents and warrants to the Company and,
with respect to Section 3(b)(ii), to each of the other Purchasers, upon the
acquisition of the Note and the Warrant by such Purchaser as follows:

               (a) Binding Obligation. Such Purchaser has full legal capacity,
power and authority to execute and deliver this Agreement and to perform its
obligations hereunder. Each Transaction Document to which it is a party is a
valid and binding obligation of the Purchaser, enforceable against it in
accordance with its terms, except as limited by bankruptcy, insolvency,
moratorium, reorganization or other laws of general application affecting the
enforcement of creditors' rights generally and general principles of equity
(regardless of whether enforcement is sought in equity or at law).

               (b) Securities Law Compliance. (i) Such Purchaser has been
advised that the Notes and the Warrants (and the Common Stock issuable upon
conversion or exercise thereof) have not been registered under the Securities
Act of 1933, as amended (the "SECURITIES ACT"), or any state securities laws
and, therefore, cannot be resold unless they are registered under the Securities
Act and applicable state securities laws or unless an exemption from such
registration requirements is available. Such Purchaser is aware that, except as
set forth in the Common Stock Purchase Agreement (as defined below), the Company
is under no obligation to effect any such registration with respect to the Notes
or Warrants (or the Common Stock issuable upon conversion or exercise thereof)
or to file for or comply with any exemption from registration. Such Purchaser
has not been

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formed solely for the purpose of making this investment and is purchasing the
Notes and the Warrants to be acquired by such Purchaser hereunder for its own
account for investment, not as a nominee or agent, and not with a view to, or
for resale in connection with, the distribution or fractionalization thereof, in
whole or in part, within the meaning of the Securities Act. Such Purchaser has
such knowledge and experience in financial and business matters that such
Purchaser is capable of evaluating the merits and risks of such investment, is
able to incur a complete loss of such investment and is able to bear the
economic risk of such investment for an indefinite period of time. Such
Purchaser is an accredited investor as such term is defined in Rule 501 of
Regulation D promulgated under the Securities Act.

               (ii) Either (A) such Purchaser and the Company, or any of their
respective officers, directors or controlling persons, have a preexisting
personal or business relationship (as such terms are used in Section 25118 of
the California Corporate Securities Law of 1968) or (B) such Purchaser has by
reason of its own business and financial experience or that of its professional
advisers, capacity to protect its own interests in connection with the
transactions (as such terms are used in Section 25118 of the California
Corporate Securities Law of 1968) contemplated by the Transaction Documents.

               (iii) Such Purchaser will not, directly or indirectly, offer,
sell, pledge, transfer or otherwise dispose of (or solicit offers to buy,
purchase or otherwise acquire or take a pledge of) any of the Notes or the
Warrants (and the Common Stock issuable upon conversion or exercise thereof),
except in compliance with the Transaction Documents and the registration
requirements of the Securities Act, and the rules and regulations promulgated
thereunder, or an exemption thereunder.

               (iv) Such Purchaser further acknowledges and understands that the
Notes and the Warrants (and the Common Stock issuable upon conversion or
exercise thereof) may not be resold or otherwise transferred except in a
transaction registered under the Securities Act or unless an exemption from such
registration is available. Such Purchaser understands that the Notes and the
Warrants (and the Common Stock issuable upon conversion or exercise thereof)
will be imprinted with a legend that prohibits the transfer of such securities
unless (A) they are registered or such registration is not required, and (B) if
the transfer is pursuant to an exemption from registration under the Securities
Act and, if the Company shall so request in writing, an opinion of counsel
reasonably satisfactory to the Company is obtained to the effect that the
transaction is so exempt.

               (c) Access to Information. Such Purchaser acknowledges that the
Company has given such Purchaser access to the corporate records and accounts of
the Company and to all information in its possession relating to the Company,
has made its officers and representatives available for interview by such
Purchaser, and has furnished such Purchaser with all documents and other
information requested by such Purchaser to make an informed decision with
respect to the purchase of the Notes and the Warrants.

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               (d) No Legal, Tax or Investment Advice. Such Purchaser
understands that nothing in this Agreement or any other materials presented to
such Purchaser in connection with the purchase of the Notes or the Warrants
constitutes legal, tax or investment advice. Such Purchaser has consulted such
legal, tax and investment advisors as it, in its sole discretion, has deemed
necessary or appropriate in connection with its purchase of the Notes and
Warrants.

        4. CONDITIONS TO CLOSING OF THE PURCHASERS. Each Purchaser's obligations
at the Closing are subject to the fulfillment, on or prior to the Closing Date,
of all of the following conditions, any of which may be waived in whole or in
part by all of the Purchasers:

               (a) Representations and Warranties. The representations and
warranties made by the Company in Section 2 hereof and the other Transaction
Documents shall have been true and correct when made, and shall be true and
correct on the Closing Date.

               (b) Governmental Approvals and Filings. Except for any notices
required or permitted to be filed after the Closing Date with certain federal
and state securities commissions (which notices will be promptly filed), the
Company shall have obtained all governmental approvals required in connection
with the lawful sale and issuance of the Notes and the Warrants and the
consummation of the transactions contemplated by the other Transaction Documents
delivered on the Closing Date.

               (c) Legal Requirements. At the Closing, the sale and issuance by
the Company, and the purchase by the Purchasers, of the Notes and the Warrants
and the consummation of the transactions contemplated by the other Transaction
Documents delivered on the Closing Date shall be legally permitted by all laws
and regulations to which the Purchasers or Company are subject.

               (d) Proceedings and Documents. All corporate and other
proceedings in connection with the transactions contemplated at the Closing and
all documents and instruments incident to such transactions shall be reasonably
satisfactory in substance and form to the Purchasers.

               (e) Opinion of Counsel. There shall have been delivered to the
Purchasers a favorable written opinion of Wilson Sonsini Goodrich & Rosati,
P.C., counsel to the Company, in the form of Exhibit C hereto, dated as of the
Closing Date.

               (f) Transaction Documents. The Company and each Purchaser, to the
extent party thereto, shall have duly executed and delivered to the Purchasers
and the Company the following documents:

                      (i)    this Agreement;

                      (ii)   each Note issued hereunder;

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                      (iii)  each Warrant issued hereunder;

                      (iv)   the Security Agreement in the form of Exhibit D
                             hereto (as amended, modified or supplemented, the
                             "SECURITY AGREEMENT");

                      (v)    the Intellectual Property Security Agreement in the
                             form of Exhibit E hereto (as amended, modified or
                             supplemented, the "INTELLECTUAL PROPERTY SECURITY
                             AGREEMENT");

                      (vi)   all UCC-1 financing statements and other documents
                             and instruments which the Purchaser may reasonably
                             request to perfect its security interest in the
                             collateral described in the Security Agreement or
                             the Intellectual Property Security Agreement; and

                      (vii)  Account Control Agreements among the Company, each
                             Purchaser and Silicon Valley Bank.

               (g) PIPE Transaction. The Company and each investor party thereto
shall have executed the Common Stock Purchase Agreement, dated as of September
19, 2002, among the Company and the investors listed on Exhibit A thereto (the
"COMMON STOCK PURCHASE Agreement") in form and substance reasonably satisfactory
to the Purchasers.

        5. CONDITIONS TO OBLIGATIONS OF THE COMPANY. The Company's obligation to
issue and sell the Notes and the Warrants at the Closing is subject to the
fulfillment, on or prior to the Closing Date, of the following conditions, any
of which may be waived in whole or in part by Company:

               (a) Representations and Warranties. The representations and
warranties made by the Purchasers in Section 3 hereof shall be true and correct
when made, and shall be true and correct on the Closing Date.

               (b) Governmental Approvals and Filings. Except for any notices
required or permitted to be filed after the Closing Date with certain federal
and state securities commissions, the Company shall have obtained all
governmental approvals required in connection with the lawful sale and issuance
of the Notes and the Warrants and the consummation of the transactions
contemplated by the other Transaction Documents delivered on the Closing Date.

               (c) Legal Requirements. At the Closing, the sale and issuance by
the Company, and the purchase by the Purchasers, of the Notes and the Warrants
and the consummation of the transactions contemplated by the other Transaction
Documents delivered on the Closing Date shall be legally permitted by all laws
and regulations to which the Purchasers or Company are subject.

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               (d) Purchase Price. Each Purchaser shall have delivered to the
Company the Purchase Price in respect of the Note and Warrant being purchased by
such Purchaser referenced in Section 1(b) hereof.

        6.     MISCELLANEOUS.

               (a) Waivers and Amendments. Any provision of this Agreement may
be amended, waived or modified only upon the written consent of the Company and
the Majority Purchasers; except that no amendment, waiver or modification of the
definition of Majority Purchasers, any provision of Schedule I, the form of Note
annexed as Exhibit A hereto, the form of Warrant annexed as Exhibit B hereto, or
any of the conditions to the Purchasers' obligations set forth herein in Section
4, and no amendment, waiver or modification of any provision of this Agreement
or any other Transaction Document which is detrimental to any Purchaser in a
manner materially different from any other Purchaser or which increases the
Maximum Loan Amount, shall be made without the consent of each affected
Purchaser. Any amendment or waiver effected in accordance with this paragraph
shall be binding upon each Purchaser and the Company.

               (b) Governing Law. This Agreement and all actions arising out of
or in connection with this Agreement shall be governed by and construed in
accordance with the laws of the State of California, without regard to the
conflicts of law provisions of the State of California or of any other state.
The Company hereby (i) submits to the non-exclusive jurisdiction of the courts
of the State of California and the Federal courts of the United States sitting
in the State of California for the purpose of any action or proceeding arising
out of or relating to this Agreement and the Transaction Documents, (ii) agrees
that all claims in respect of any such action or proceeding may be heard and
determined in such courts, (iii) irrevocably waives (to the extent permitted by
applicable law) any objection which it now or hereafter may have to the laying
of venue of any such action or proceeding brought in any of the foregoing
courts, and any objection on the ground that any such action or proceeding in
any such court has been brought in an inconvenient forum, and (iv) agrees that a
final judgment in any such action or proceeding shall be conclusive and may be
enforced in other jurisdictions by suit on the judgment or in any other manner
permitted by law.

               THE COMPANY AND THE PURCHASERS HEREBY WAIVE THEIR RESPECTIVE
RIGHTS TO A TRIAL BY JURY OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING
OUT OF OR RELATED TO THIS AGREEMENT OR THE OTHER TRANSACTION DOCUMENTS OR THE
TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY IN ANY ACTION, PROCEEDING OR OTHER
LITIGATION OF ANY TYPE BROUGHT BY ANY OF THE PARTIES AGAINST ANY OTHER PARTY OR
PARTIES, WHETHER WITH RESPECT TO CONTRACT CLAIMS, TORT CLAIMS, OR OTHERWISE. THE
COMPANY AND THE PURCHASERS HEREBY AGREE THAT ANY SUCH CLAIM OR CAUSE OF ACTION
SHALL BE TRIED BY A COURT TRIAL WITHOUT A JURY. WITHOUT IN ANY WAY LIMITING THE
FOREGOING, THE COMPANY AND THE PURCHASERS FURTHER AGREE THAT THEIR RESPECTIVE

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RIGHT TO A TRIAL BY JURY IS WAIVED BY OPERATION OF THIS SECTION AS TO ANY
ACTION, COUNTERCLAIM, OR OTHER PROCEEDING WHICH SEEKS, IN WHOLE OR IN PART, TO
CHALLENGE THE VALIDITY OR ENFORCEABILITY OF THIS AGREEMENT OR OTHER TRANSACTION
DOCUMENTS OR ANY PROVISION HEREOF OR THEREOF. THIS WAIVER SHALL APPLY TO ANY
SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS AGREEMENT
OR THE OTHER TRANSACTION DOCUMENTS. A COPY OF THIS SECTION MAY BE FILED WITH ANY
COURT AS WRITTEN EVIDENCE OF THE WAIVER OF THE RIGHT TO TRIAL BY JURY AND
CONSENT TO TRIAL BY COURT.

               (c) Survival. The representations, warranties, covenants and
agreements made herein shall survive the execution and delivery of this
Agreement.

               (d) Successors and Assigns. The rights and obligations of the
Company and the Purchasers under this Agreement shall be binding upon and
benefit their respective successors, assigns, heirs, administrators and
transferees.

               (e) Registration, Transfer and Replacement of the Notes. The
Notes issued under this Agreement shall be registered notes. The Company will
keep, at its principal executive office, books for the registration and
registration of transfer of the Notes. The failure of the Company to make a
notation in the register shall in no way affect the validity of any sale,
transfer or assignment of a Note or Warrant made in compliance with the terms
thereof. Prior to presentation of any Note for registration of transfer, the
Company shall treat the Person in whose name such Note is registered as the
owner and holder of such Note for all purposes whatsoever, whether or not such
Note shall be overdue, and the Company shall not be affected by notice to the
contrary. Subject to any restrictions on or conditions to transfer set forth in
any Note, the holder of any Note, at its option, may in person or by duly
authorized attorney surrender the same for exchange at the Company's chief
executive office, and promptly thereafter and at the Company's expense, except
as provided below, receive in exchange therefor one or more new Note(s), each in
the principal requested by such holder, dated the date to which interest shall
have been paid on the Note so surrendered or, if no interest shall have yet been
so paid, dated the date of the Note so surrendered and registered in the name of
such Person or Persons as shall have been designated in writing by such holder
or its attorney for the same principal amount as the then unpaid principal
amount of the Note so surrendered. Upon receipt by the Company of evidence
reasonably satisfactory to it of the ownership of and the loss, theft,
destruction or mutilation of any Note and (a) in the case of loss, theft or
destruction, of indemnity reasonably satisfactory to it; or (b) in the case of
mutilation, upon surrender thereof, the Company, at its expense, will execute
and deliver in lieu thereof a new Note executed in the same manner as the Note
being replaced, in the same principal amount as the unpaid principal amount of
such Note and dated the date to which interest shall have been paid on such Note
or, if no interest shall have yet been so paid, dated the date of such Note.

                                       11
<PAGE>

               (f) Assignment by the Company. None of the rights, interests or
obligations hereunder may be assigned, by operation of law or otherwise, in
whole or in part, by Company without the prior written consent of the Majority
Purchasers.

               (g) Entire Agreement. This Agreement together with the Notes, the
Warrants and the other Transaction Documents and the Common Stock Purchase
Agreement constitute the full and entire understanding and agreement between the
parties with regard to the subjects hereof and thereof.

               (h) Notices. All notices and other communications required or
permitted under this Agreement shall be effective upon receipt and shall be in
writing and may be delivered in person, by telecopy, overnight delivery service
or registered or certified United States mail, addressed:

        If to the Company:          Vicente Anido, Jr., PhD.
                                    Chief Executive Officer
                                    15279 Alton Parkway, #100
                                    Irvine, CA  92618
                                    Facsimile:  (949) 789-7744

        With a courtesy copy to:    Issac J. Vaughn, Esq.
                                    Wilson Sonsini Goodrich & Rosati
                                    650 Page Mill Rd.
                                    Palo Alto, CA  94304
                                    Facsimile:  (650) 493-9811

        If to the Purchaser:        The address set forth next to such
                                    Purchaser's name in Schedule I

        with a courtesy copy to:    Warren T. Lazarow, Esq.
                                    Brobeck, Phleger & Harrison LLP
                                    2000 University Avenue
                                    East Palo Alto, CA 94303
                                    Facsimile:  (650) 331-8107

               All notices and other communications shall be effective upon the
earlier of actual receipt thereof by the person to whom notice is directed or
(i) in the case of notices and communications sent by personal delivery or
telecopy, one Business Day after such notice or communication arrives at the
applicable address or was successfully sent to the applicable telecopy number,
(ii) in the case of notices and communications sent by overnight delivery
service, at noon (local time) on the second Business Day following the day such
notice or communication was sent,

                                       12
<PAGE>

and (iii) in the case of notices and communications sent by United States mail,
seven days after such notice or communication shall have been deposited in the
United States mail.

               (i) Expenses. The Company shall pay on demand all reasonable fees
and expenses, including reasonable attorneys' fees and expenses, incurred by any
Purchaser in the enforcement or attempted enforcement of any of the obligations
of the Company under the Transaction Documents or in preserving any of the
Purchasers' rights and remedies (including, without limitation, all such fees
and expenses incurred in connection with any "workout" or restructuring
affecting the Transaction Documents or the obligations thereunder or any
bankruptcy or similar proceeding involving the Company).

               (j) Relationship of Purchasers. The Company's agreement with each
of the Purchasers is a separate agreement and the sale of the Notes and the
Warrants to each of the Purchasers is a separate sale. The rights and
obligations of each Purchaser hereunder are several and not joint. Any
invalidity, illegality or limitation on the enforceability of the Agreement, the
Common Stock Purchase Agreement or any Transaction Documents or any part
thereof, by any Purchaser whether arising by reason of the law of the respective
Purchaser's domicile or otherwise, shall in no way affect or impair the
validity, legality or enforceability of this Agreement, the Common Stock
Purchase Agreement or any Transaction Documents with respect to other
Purchasers. The failure of any Purchaser to carry out its obligations under this
Agreement, the Common Stock Purchase Agreement or any Transaction Documents
shall not relieve the Company or any other Purchaser of any obligation
thereunder, nor shall any Purchaser be responsible for the obligations of, or
any action taken or omitted by, any other person hereunder or thereunder.
Nothing contained in this Agreement, the Common Stock Purchase Agreement or any
Transaction Documents shall be deemed to cause any Purchaser to be considered a
partner, trustee or fiduciary for or joint venturer with any other Purchaser or
the Company. It is not the intent of the Purchasers, or the Representative, to
create or constitute, and nothing in this Agreement, the Common Stock Purchase
Agreement or any other Transaction Document shall be treated as creating or
constituting, the Purchasers or any number of the Purchasers or the
Representative and any Purchaser as a "group within the meaning of the Exchange
Act or any of the rules promulgated thereunder (including SEC Rule 13d-5).
Except as expressly provided herein, each Purchaser shall severally remain
responsible for holding its Obligations, and the collection, servicing and
administration thereof and shall be free to deal with its Obligations as it sees
fit.

               (k) Severability of this Agreement. Whenever possible, each
provision of this Agreement shall be interpreted in such manner as to be valid,
legal and enforceable under all applicable laws and regulations. If, however,
any provision of this Agreement shall be invalid, illegal or unenforceable under
any such law or regulation in any jurisdiction, it shall, as to such
jurisdiction, be deemed modified to conform to the minimum requirements of such
law or regulation, or if for any reason it is not deemed so modified, it shall
be invalid, illegal or unenforceable only to the extent of such invalidity,
illegality or limitation on enforceability without affecting the remaining
provisions of this Agreement, or the validity, legality or enforceability of
such provision in any other

                                       13
<PAGE>

jurisdiction.

               (l) Sharing (i) The Company agrees that all payments on account
of the Notes shall be made ratably among the Purchasers in accordance with their
Pro Rata Shares (as defined herein). For the purposes of this Section 6(l) a
conversion of any Note in accordance with the terms thereof shall not be
considered a payment on account of such Note. For avoidance of doubt, in the
event that a Transaction Fee (as defined in the Notes) is payable pursuant to
any Note, the Company shall not make payments on account of such Transaction Fee
to the holder of any Note who (pursuant to the terms of their Note) is not
entitled to receive a Transaction Fee from the Company. The Company agrees that
it shall not, without the prior consent of the Majority Purchasers, amend the
provisions of any Note.

               (ii) Each Purchaser acknowledges and agrees that all Debt
Payments (as defined herein) on account of the Obligations (as such term is
defined in the Security Agreement) shall be made on a pro rata basis, in
accordance with each Purchaser's Pro Rata Share at the time of payment. Without
limiting the generality of the foregoing, each Purchaser agrees that upon the
occurrence of any Event of Default (as such term is defined in the Notes) and so
long as such Event of Default continues, any and all Debt Payments shall be
applied in the following order: (1) first, for application to the payment of any
fees, costs, expenses of the Purchasers in connection with the enforcement of
the Notes and the Collateral (as such term is defined in the Security
Agreement); and (2) second, ratably in accordance with their Pro Rata Shares,
for application to the payment of (A) accrued and unpaid interest on the Notes,
then (B) the outstanding principal of the Notes and (C) the other Obligations.
For the avoidance of doubt, and without prejudice to the generality of the
foregoing, in no event shall a Purchaser be required to share any Transaction
Fee (as defined in the Notes) payable to it in respect of the Notes with any
Purchaser who is not entitled to receive a Transaction Fee pursuant to the terms
of its Note.

               (iii) If, despite the provisions of this Section 6(l), any
Purchaser shall receive any Debt Payment in excess of its Pro Rata Share to
which it is then entitled in accordance with this Agreement, such Purchaser
shall hold such excess Debt Payment in trust for the benefit of the Purchasers
entitled thereto and promptly pay over or deliver such excess Debt Payment to
the other Purchasers for application in accordance with this Agreement.
Additionally, such Purchaser shall, if so required by the Majority Purchasers,
purchase from the other Purchasers such participations in their respective
Obligations as shall be required by them to permit the sharing of such excess
Debt Payment in accordance with the requirements of this Agreement. If all or
any portion of such excess Debt Payment is thereafter recovered by or on behalf
of the Company from such Purchaser, each other party which shares in the benefit
thereof shall return to such Purchaser its portion of the payment so recovered.

               (iv) Subject to Section 6(a) and the express terms of the
Transaction Documents, each of the Purchasers hereby agrees that the Majority
Purchasers shall have the right, power and authority to direct the manner of any
and all action taken by the Purchasers and the Representative (as defined

                                       14
<PAGE>

below) in respect of (A) the enforcement of the Transaction Documents or
remedial action in respect thereof and (B) the granting of waivers or making of
amendments with respect to any Transaction Documents and further agrees that any
such direction by or approval of the Majority Purchasers shall be binding on all
Purchasers. Subject to subsection (v), nothing in the foregoing shall prevent or
restrict the ability of any Purchaser to exercise any enforcement rights of such
Purchaser (to the extent not inconsistent with a direction from the Majority
Purchasers as to the manner of the enforcement of remedies).

               (v) Notwithstanding the foregoing or anything to the contrary in
this Agreement, if so directed by the Majority Purchasers, no Purchaser shall,
or if already commenced shall continue in, any of the following actions (unless
authorized by the Majority Purchasers):

               (1)    accelerate or otherwise make due and payable prior to the
                      original stated maturity thereof any Obligations or bring
                      suit or institute any other actions or proceedings to
                      enforce its rights or interests under or in respect of any
                      Transaction Document;

               (2)    exercise any right of set-off, counterclaim, banker's lien
                      or other claim it may have against the Company or any
                      other person with respect to the Obligations;

               (3)    exercise any rights under or with respect to (A)
                      guaranties of the Obligations, or (B) any Collateral,
                      including causing or compelling the pledge or delivery of
                      any Collateral, any attachment of, levy upon, execution
                      against, foreclosure upon or the taking of other action
                      against or institution of other proceedings with respect
                      to any Collateral, notifying any account debtors of the
                      Company or asserting any claim or interest in any
                      insurance with respect to any Collateral, or release any
                      Collateral or other guaranties; or

               (4)    commence, or cause to be commenced, or join with any
                      creditor in commencing, any bankruptcy, insolvency or
                      receivership proceeding against the Company.

               (vi) Each Purchaser acknowledges and agrees that neither any
other Purchaser nor the Representative (nor any of their officers, directors,
employees, agents, advisors or attorneys) has represented it or otherwise been
responsible for acting for it in connection with the preparation, negotiation or
execution and delivery of this Agreement or any other Transaction Document or
the Common Stock Purchase Agreement and that each Purchaser has made its own
independent review and appraisal of, and sought its own independent advice (and,
if it has not sought such advice, assumes the risks associated with not
obtaining such advice) regarding, the terms of the Transaction Documents or the
Common Stock Purchase Agreement and structure of the transactions contemplated
thereby, the scope and nature of the Collateral, the financial or other
condition of the Company, its Subsidiaries and all other matters pertaining to
the Transaction Documents or the Common Stock Purchase Agreement or the
transactions contemplated thereby. Neither any Purchaser nor the Representative
shall have any obligation or duty to ensure the compliance by the Company or any
Purchaser or the Representative with the conditions specified in any Transaction

                                       15
<PAGE>

Document for any extension of credit to the Company. Each Purchaser by executing
this Agreement shall be deemed to have consented to, approved or accepted and to
be satisfied with, each document or other matter required to be consented to or
approved by or acceptable or satisfactory to the Purchasers. Each Purchaser
acknowledges and agrees that: (A) neither any Purchaser nor the Representative
has any implied or other duties to any other Purchaser or any other Person; (B)
except as otherwise expressly agreed herein, each Purchaser can advance its own
interests as it sees fit; and (C) no other role or position of any Purchaser or
the Representative or any Affiliate, officer, employee, attorney or agent of any
Purchaser or the Representative with respect to the Company, a Purchaser or any
other Person, shall impair or alter any the Purchaser's or Representative's
rights or otherwise create any liability or obligation to the other Purchasers.

               (vii) Each Purchaser has itself been, and will continue to be,
based on such documents and information as it has deemed appropriate, solely
responsible for making its own independent appraisal of and investigations into
the financial condition, creditworthiness, condition, affairs, status and nature
of the Company or any of its Subsidiaries and the nature and value of any
Obligation and Collateral. Accordingly, each Purchaser confirms to the other
Purchasers and the Representative that it has not relied, and will not hereafter
rely, on the other Purchasers or the Representative (A) to check or inquire on
such Purchaser's behalf into the adequacy, accuracy or completeness of any
information provided by the Company or any other person under or in connection
with this Agreement or the transactions contemplated by the Transaction
Documents, Control Agreement or the Common Stock Purchase Agreement (whether or
not such information has been or is hereafter distributed to such Purchaser), or
(B) to assess or keep under review on such Purchaser's behalf, the financial
condition, creditworthiness, condition, affairs, status or nature of the
Company, any Subsidiary or the nature or value of any Collateral.

               (viii) Each of the Purchasers and the Representative and their
respective Affiliates may make loans to, acquire equity interests in, and
generally engage in any kind of banking, trust, financial advisory,
underwriting, equity investment, venture capital, or other business with the
Company or its Subsidiaries or the Purchasers and their Affiliates as though
such Purchaser or Representative (as applicable) was not a Purchaser or
Representative hereunder and without notice to or consent of the other
Purchasers. The Purchasers acknowledge that, pursuant to such activities, a
Purchaser or Representative (as applicable) or its Affiliates may receive
information regarding the Company and its Subsidiaries (including information
that may be subject to confidentiality obligations in favor of such person) and
acknowledge that such Purchaser or Representative (as applicable) shall be under
no obligation to provide such information to them.

               (ix) This Section 6(l) been entered into for the sole protection
and benefit of the Purchasers, Representative and their respective successors
and assigns, and no other person, including, but not limited to the Company,
shall be a direct or indirect beneficiary of, or shall have any direct or
indirect cause of action or claim in connection with, this Section 6(l).

               (m) Certain Definitions. For the purposes of this Agreement,

                                       16
<PAGE>

               "BALANCE SHEET" means the most recent unaudited consolidated
balance sheet of the Company and its Subsidiaries included in the Financial
Statements.

               "BALANCE SHEET DATE" means June 30, 2002, the date of the Balance
Sheet.

               "BUSINESS DAY" means any day other than a Saturday, a Sunday or a
day on which commercial banks in The City of New York are (or are permitted or
required by law, rule, regulation, order or state of emergency to be) closed.

               "COMPANY AGREEMENT" means any note, bond, mortgage, indenture,
lease, license, contract, agreement, arrangement or other instrument or
obligation to which the Company or any of its Subsidiaries is a party of by
which any of them or any of their properties or assets may be bound.

               "COMPANY DISCLOSURE SCHEDULE" has the meaning set forth in the
Common Stock Purchase Agreement.

               "COMPANY SEC DOCUMENTS" means each form, report, schedule,
statement and other document filed or required to be filed by the Company since
August 25, 2000 through the date of this Agreement under the Exchange Act or the
Securities Act, including any amendment filed to such document, whether or not
such amendment is required to be so filed.

               "DEBT PAYMENT" means any payment or distribution by or on behalf
of the Company, directly or indirectly, of assets of the Company of any kind or
character, whether in cash, property or securities, including on account of the
purchase, redemption or other acquisition of any Obligations, as a result of any
collection, sale or other disposition of Collateral, or by setoff, exchange or
in any other manner, for or on account of any Obligations; provided, however,
that, conversion of any part of a Note in accordance with its terms shall not be
considered a Debt Payment.

               "EXCHANGE ACT" means Securities Exchange Act of 1934, as amended,
and the applicable rules and regulations of the Securities and Exchange
Commission promulgated thereunder.

               "FINANCIAL STATEMENTS" means each of the audited consolidated
financial statements and unaudited condensed consolidated interim financial
statements of the Company (including any related notes and schedules) included
(or incorporated by reference) in the Company SEC Documents.

               "GAAP" means United States generally accepted accounting
principles.

               "MAJORITY PURCHASERS" means at any time Purchasers holding at
least eighty percent (80%) of the then aggregate unpaid Obligations; provided,
that that any portion of a Purchaser's Note

                                       17
<PAGE>

converted into equity of the Company shall not be considered outstanding for the
purposes of this definition. For the purposes of the foregoing, affiliated
entities shall be deemed a single Purchaser.

               The "PRO RATA SHARE" of a Purchaser means the proportion which
the unpaid Obligations of that Purchaser bears to the aggregate unpaid
Obligations of all Purchasers; provided, however, that any portion of an
Purchaser's Obligations converted to equity shall not be considered outstanding
for these purposes; and provided further, that the Pro Rata Share of any
Purchaser of any Transaction Fees payable pursuant to the Notes means the
proportion which the unpaid Transaction Fee payable to such Purchaser pursuant
to such Purchaser's Note bears to the aggregate unpaid Transaction Fee payable
to all Purchasers pursuant to their Notes.

               "SEC" means the U.S. Securities and Exchange Commission (or any
successor thereto).

               "TRANSACTIONS" has the meaning set forth in the Common Stock
Purchase Agreement.

        (n) Representative and Collateral Agent

        (i) Appointment. The Purchasers hereby appoint Sanderling Venture
Partners V Co-Investment Fund, L.P. and Sanderling Venture Partners V
Co-Investment Fund, L.P., hereby accepts such appointment as the Purchasers'
initial representative and collateral agent ("REPRESENTATIVE") for the purpose
of entering, for the benefit of the Purchasers, into any control agreements
(each a "CONTROL AGREEMENT") required or advisable (in the opinion of the
Majority Purchasers) for the perfection of any security interests of the
Purchasers in the Collateral (as defined in the Security Agreement) and for
acting on behalf of the Purchasers in connection with any Control Agreement.

        (ii) Authorization and Action. Each Purchaser hereby authorizes the
Representative to take such action on its behalf and to exercise such rights and
powers as are delegated to the Representative by the terms hereof, together with
such powers as are reasonably incidental thereto. Notwithstanding anything to
the contrary in any Transaction Document, the duties and obligations of the
Representative are strictly limited to those expressly provided for in this
Section 6(n), and no implied covenants, functions, responsibilities, duties,
obligations or liabilities shall be read into this Agreement or otherwise exist
against the Representative. The Representative shall not be required to exercise
any discretion or take any action, but may act or refrain from acting upon the
instructions of the Majority Purchasers and shall incur no liability to any
Purchaser for any action or refraining from any action, or otherwise acting at
the directions of, or upon the instructions of the Majority Purchasers, and such
instructions shall be binding upon all Purchasers; provided, however, that the
Representative shall in all cases be fully justified in failing or refusing to
act hereunder unless it shall be indemnified to its satisfaction by the
Purchasers against any and all liability and expense which may be incurred by
reason of taking or continuing to take any such action, and that the
Representative shall not in any event be required to take any action which
exposes the Representative to liability or which is contrary to this Agreement
or any other Transaction Document

                                       18
<PAGE>

or applicable law.

        (iii) Relationship of Purchasers and Representative. Nothing in this
Agreement shall, or shall be construed to, constitute the Representative as a
partner, trustee, fiduciary for or joint venturer with any Purchaser. In
accepting its appointment hereunder, the Representative is agreeing to undertake
merely an administrative function to assist with the perfection of the security
interests of the Purchasers and as an accommodation to satisfy the requirements
imposed upon the Purchasers by third party depository institutions and
securities intermediaries (who may insist upon a single representative for the
secured parties). The waivers, exculpations and indemnities provided to the
Representative are a material inducement, and reason for the willingness of
Representative, to act and the Representative would not have agreed to so act in
the absence of such waivers, exculpations and indemnities. In performing its
functions and duties hereunder, the Representative shall act solely as the
representative of the Purchasers and does not assume and shall not be deemed to
have assumed any obligation towards or relationship of agency or trust with or
for the Company or any other Person.

        (iv) Delegation of Duties. The Representative may, in its discretion,
employ from time to time one or more agents or attorneys-in-fact (including any
of the Representative's Affiliates) to perform any of the Representative's
functions or exercise its powers under this Agreement or any Control Agreement
and shall be entitled to advice of counsel concerning all matters pertaining to
its rights, powers and functions hereunder. The Representative shall not be
responsible for the negligence or misconduct of any such agents or
attorneys-in-fact.

        (v) General Rights and Powers of Representative. The rights and powers
of the Representative hereunder shall consist of: (i) exercising or refraining
from exercising any rights, remedies or powers of the Purchasers under the
Control Agreements, or under applicable law in respect of the Control
Agreements, (ii) making any demands or giving any notices under the Control
Agreements, (iii) effecting amendments to and granting waivers under the Control
Agreements, and (iv) distributing payments to the Purchasers of amounts paid to
pursuant to any Control Agreements. Provided that nothing in this Agreement, or
any other Transaction Document, shall require the Representative to exercise or
preserve any of its rights, privileges or powers. Representative shall in all
circumstances be entitled, before exercising any of the rights or powers granted
to it, or otherwise acting in its capacity as Representative, to obtain the
written direction or approval of the Majority Purchasers.

        (vi) Limitation on Liability. Neither the Representative nor any
Affiliate thereof nor any of their respective directors, officers, employees,
attorneys or agents shall be liable for any action taken or omitted to be taken
by it or them in their capacity as Representative under or in connection with
this Agreement or the Control Agreements. Without limitation of the generality
of the foregoing, the Representative shall incur no liability to any Purchaser
under or in respect of this Agreement or any Control Agreements by acting upon
any notice, consent, certificate, telegram, facsimile, electronic mail or other
electronic communications, telex or teletype message, statement or other
instrument or

                                       19
<PAGE>

writing believed by it to be genuine and signed or authenticated or sent by the
proper party or parties or by acting upon any representation or warranty made or
deemed to be made hereunder or under any other Transaction Document or
agreement.

        (vii) Notice of Default. The Representative shall not be deemed to have
knowledge or notice of the occurrence of any Event of Default unless the
Representative shall have received written notice from a Purchaser referring to
this Agreement and describing such Event of Default.

        (viii) Indemnification of Representative. The Purchasers jointly and
severally agree to indemnify the Representative, its Affiliates, and their
respective directors, officers, employees, agents, counsel and other advisors
(each an "Indemnitee") against, and hold each of them harmless from, any and all
liabilities, obligations, losses, claims, damages, penalties, actions,
judgments, suits, costs, expenses or disbursements of any kind or nature
whatsoever, including the fees and disbursements of counsel to the
Representative, which may be imposed on, incurred by, or asserted against any
Indemnitee in any way relating to or arising out of this Agreement or any
Control Agreement or the transactions contemplated hereby or thereby or any
action taken or omitted by any Indemnitee in connection with any of the
foregoing; provided that no Purchaser shall be liable to any Indemnitee for any
portion of such liabilities, obligations, losses, damages, penalties, actions,
judgments, suits, costs, expenses or disbursements to the extent they are found
by a final decision of a court of competent jurisdiction to have resulted from
such Indemnitee's gross negligence or willful misconduct.

        (ix) Benefits of Agreement. This Section 6(n) been entered into for the
sole protection and benefit of the Purchasers, Representative and their
respective successors and assigns, and no other person, including, but not
limited to the Company, shall be a direct or indirect beneficiary of, or shall
have any direct or indirect cause of action or claim in connection with, this
Section 6(n).

               (o) Public Announcement. Except as may be required by law or
regulation, the Company shall not use the name of, or make reference to, any
Purchaser or any of its Affiliates in any press release or in any public manner
(including any reports or filings made by the Company under the Exchange Act)
without such Purchaser's prior written consent which consent shall not be
unreasonably withheld. The initial press release with respect to the execution
of this Agreement shall be approved by the Company and Sprout Capital IX, L.P.
and [Sanderling Ventures and Affiliates] on behalf of the Purchasers.
Thereafter, so long as this Agreement is in effect, the Company and the
Purchasers shall consult with each other before issuing any press release or
otherwise making any public statements with respect to this Agreement or the
transactions contemplated hereby without the prior consent of the other party,
which consent shall not be unreasonably withheld; provided, however, that the
Company, on the one hand, and the Purchasers, on the other hand, may, without
the prior consent of the other party, issue a press release or make such public
statement as may, upon the advice of counsel, be required by law if it has used
all reasonable efforts to consult with the other party and the Purchasers may
make public statements in

                                       20
<PAGE>

connection with the exercise of their remedies under the Transaction Documents
and, subject to compliance with applicable securities laws, in connection with
transfers of the Notes and Warrants.

               (p) Post Closing Matters. Whereas the Company is required, as a
condition precedent to the obligations of the Purchasers to purchase the Notes,
to deliver certain documents or to perform certain actions prior to the Closing
Date. The Company is unable to so deliver all of the documents or to perform all
of the actions required by the Purchasers prior to Closing. The Purchasers have
agreed, notwithstanding the non-delivery of such documents and non-performance
of such actions, to close the purchase of the Notes, but subject to the
agreement of the Company to delivery the documents and perform the actions
specified in Exhibit F by the dates indicated therein. The Purchasers further
acknowledge that such failure to deliver such documents or to perform such
actions prior to the dates specified in Exhibit F, shall not, of itself,
constitute a breach of this Agreement or the other Transaction Documents. The
Company acknowledges and agrees that, notwithstanding anything to the contrary
in any other agreement, the failure of the Company to provide such deliverables
or to undertake such actions by the date prescribed in Exhibit F shall be deemed
to constitute an immediate Event of Default under the Notes.

               (q) Indemnification. Whether or not the transactions contemplated
hereby shall be consummated, the Company hereby agrees to indemnify the
Purchasers and their respective directors, officers, employees, agents, counsel
and other advisors (each an "INDEMNIFIED PERSON") against, and hold each of them
harmless from, any and all liabilities, obligations, losses, claims, damages,
penalties, actions, judgments, suits, costs, expenses or disbursements of any
kind or nature whatsoever, including the reasonable fees and disbursements of
counsel to an Indemnified Person (including allocated costs of internal
counsel), which may be imposed on, incurred by, or asserted against any
Indemnified Person, (i) in any way relating to or arising out of any of the
Transaction Documents, the use or intended use of the proceeds of the Notes, or
the transactions contemplated hereby or thereby, or (ii) with respect to any
investigation, litigation or other proceeding relating to any of the foregoing,
irrespective of whether the Indemnified Person shall be designated a party
thereto (the "INDEMNIFIED LIABILITIES"); provided, however, that the Company
shall not be liable to any Indemnified Person for any portion of such
Indemnified Liabilities to the extent that they are found by a final decision of
a court of competent jurisdiction to have resulted from such Indemnified
Person's gross negligence or willful misconduct, or from the breach of a
material obligation owed to the Company by such Indemnified Person in connection
with the Transaction Documents. If and to the extent that the foregoing
indemnification is for any reason held unenforceable, the Company agrees to make
the maximum contribution to the payment and satisfaction of each of the
Indemnified Liabilities which is permissible under applicable law.

                                       21
<PAGE>

               (r) Counterparts. This Agreement may be executed in any number of
counterparts, each of which shall be an original, but all of which together
shall be deemed to constitute one instrument.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                       22
<PAGE>

        IN WITNESS WHEREOF, the parties have caused this Agreement to be duly
executed and delivered by their proper and duly authorized officers as of the
date and year first written above.

                                        COMPANY:

                                        ISTA PHARMACEUTICALS, INC.
                                        a Delaware corporation

                                        By:
                                           -------------------------------------
                                        Name:
                                             -----------------------------------
                                        Title:
                                              ----------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                                        PURCHASERS:

                                        SPROUT CAPITAL IX, L.P.
                                        BY:  DLJ CAPITAL CORPORATION
                                        ITS: MANAGING DIRECTOR

                                        By:
                                           -------------------------------------
                                        Name:  Kathleen D. LaPorte
                                             -----------------------------------
                                        Title: Managing Director
                                              ----------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                                        PURCHASERS:

                                        SPROUT ENTREPRENEURS' FUND, L.P.
                                        BY: DLJ CAPITAL CORP.
                                        ITS: GENERAL PARTNER

                                        By:
                                           -------------------------------------
                                        Name:  Kathleen D. LaPorte
                                             -----------------------------------
                                        Title: Managing Director
                                              ----------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                            PURCHASERS:

                            DONALDSON, LUFKIN & JENRETTE SECURITIES CORPORATION,
                            AS NOMINEE FOR:
                            DLJ FIRST ESC, L.P.
                            EMA 2001 PLAN, L.P.
                            CSFB 2001 INVESTORS, L.P.
                            CREDIT SUISSE FIRST BOSTON PRIVATE EQUITY, INC.
                            DOCKLANDS 2001 PLAN, L.P.
                            PARADEPLATZ 2001 PLAN, L.P.

                            By:
                               -------------------------------------------------
                            Name:  Kathleen D. LaPorte
                                 -----------------------------------------------
                            Title: Attorney in fact
                                  ----------------------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                                        PURCHASERS:

                                        INVESTOR GROWTH CAPITAL LIMITED

                                        By:
                                           -------------------------------------
                                        Name:
                                             -----------------------------------
                                        Title:
                                              ----------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                                        PURCHASERS:

                                        INVESTOR GROUP L.P.

                                        By:
                                           -------------------------------------
                                        Name:
                                             -----------------------------------
                                        Title:
                                              ----------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                                        PURCHASERS:

                                        Dionis Trust

                                        By:
                                           -------------------------------------
                                        Name:
                                             -----------------------------------
                                        Title:
                                              ----------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                                        PURCHASERS:

                                        Grant Gund 1978 Trust

                                        By:
                                           -------------------------------------
                                        Name:
                                             -----------------------------------
                                        Title:
                                              ----------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                                        PURCHASERS:

                                        G. Zachary Gund 1978 Trust

                                        By:
                                           -------------------------------------
                                        Name:
                                             -----------------------------------
                                        Title:
                                              ----------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                                        PURCHASERS:

                                        KBL HEALTHCARE, LP

                                        By:
                                           -------------------------------------
                                        Name:  Marlene Krauss
                                             -----------------------------------
                                        Title: Managing Director
                                              ----------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                                        PURCHASERS:

                                        KBL PARTNERSHIP, LP

                                        By:
                                           -------------------------------------
                                        Name:  Marlene Krauss
                                             -----------------------------------
                                        Title: Managing Director
                                              ----------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                                        PURCHASERS:

                                        SANDERLING VENTURE PARTNERS V CO-
                                        INVESTMENT FUND, L.P.
                                        BY:  MIDDLETON, MCNEIL & MILLS
                                             ASSOCIATES V, LLC

                                        By:
                                           -------------------------------------
                                        Name:  Robert G. McNeil
                                             -----------------------------------
                                        Title: Managing Director
                                             -----------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                                        PURCHASERS:

                                        SANDERLING V BIOMEDICAL CO-INVESTMENT
                                        FUND, L.P.
                                        BY:  MIDDLETON, MCNEIL & MILLS
                                             ASSOCIATES V, LLC

                                        By:
                                           -------------------------------------
                                        Name:  Robert G. McNeil
                                             -----------------------------------
                                        Title: Managing Director
                                              ----------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                                    PURCHASERS:

                                    SANDERLING V LIMITED PARTNERSHIP
                                    BY:  MIDDLETON, MCNEIL & MILLS ASSOCIATES
                                         V, LLC

                                    By:
                                       -----------------------------------------
                                    Name:  Robert G. McNeil
                                         ---------------------------------------
                                    Title: Managing Director
                                          --------------------------------------

             [Signature page to Note and Warrant Purchase Agreement]

<PAGE>

                                    PURCHASERS:

                                    SANDERLING V BETEILIGUNGS GMBH & CO. KG
                                    BY:  MIDDLETON, MCNEIL & MILLS ASSOCIATES V,
                                         LLC

                                    By:
                                       -----------------------------------------
                                    Name:  Robert G. McNeil
                                         ---------------------------------------
                                    Title: Managing Director
                                          --------------------------------------

            [Signature page to Note and Warrant Purchase Agreement]
<PAGE>

                                   SCHEDULE I

                             SCHEDULE OF PURCHASERS

<TABLE>
<CAPTION>
------------------------------------------------------------------------------------------------------------------------------------
                                                      PRINCIPAL AMOUNT OF SENIOR       NUMBER OF          WIRE         PURCHASE
PURCHASER                                              SECURED CONVERTIBLE NOTE      WARRANT SHARES    INSTRUCTIONS     PRICE
------------------------------------------------------------------------------------------------------------------------------------
<S>                                                   <C>                            <C>               <C>             <C>
Sprout Capital IX, L.P.                                          $633,961                436,816                       $663,961
c/o Sprout Group
11 Madison Avenue, 13th Floor
New York, NY  10010
Attn:  Craig Slutzkin
Telephone: (212) 538-8245
Facsimile: (212) 538-8245
---------------------------------------------------------------------------------------------------------------------------------
Sprout Entrepreneurs' Fund, L.P.                                   $2,617                  1,722                         $2,617
c/o Sprout Group
11 Madison Avenue, 13th Floor
New York, NY  10010
Attn:  Craig Slutzkin
Telephone:  (212) 538-8245
Facsimile:  (212) 538-8245
---------------------------------------------------------------------------------------------------------------------------------
Donaldson, Lufkin & Jenrette Securities Corporation               $33,422                 21,988                        $33,422
(as nominee for: DLJ First ESC, L.P., EMA 2001
Plan, L.P., CSFB 2001 Investors, L.P., Credit
Suisse First Boston Private Equity, Inc., Docklands
2001 Plan, L.P. and Paradeplatz 2001 Plan, L.P.)
c/o Sprout Group
11 Madison Avenue, 13th Floor
New York, NY  10010
Attn:  Craig Slutzkin
Telephone:  (212) 538-8245
Facsimile:  (212) 538-8245
---------------------------------------------------------------------------------------------------------------------------------
Investor Growth Capital Limited                                  $490,000                322,368                       $490,000
National Westminster House
Le Truchot, St. Peter Port
Guernsey GY1 4PW
Channel Islands
Telephone:  44-1481-732-615
Facsimile:  44-1481-732-616
---------------------------------------------------------------------------------------------------------------------------------
Investor Group L.P.                                              $210,000                138,158                       $210,000
National Westminster House
Le Truchot, St. Peter Port
Guernsey GY1 4PW
Channel Islands
Telephone:  44-1481-732-615
Facsimile:  44-1481-732-616
---------------------------------------------------------------------------------------------------------------------------------
Dionis Trust                                                     $350,000                230,263                       $350,000
c/o Gund Investment Corporation
14 Nassau Street
Princeton, NJ  08542
Attention:  Mr. Theodore Baker
Facsimile:  (609) 921-7697
---------------------------------------------------------------------------------------------------------------------------------
Grant Gund 1978 Trust                                            $175,000                115,132                       $175,000
c/o Gund Investment Corporation
14 Nassau Street
Princeton, NJ  08542
Attention:  Mr. Theodore Baker
Telephone:  (609) 921-3633
Facsimile:  (609) 921-7697
---------------------------------------------------------------------------------------------------------------------------------
G. Zachary Gund 1978 Trust                                       $175,000                115,132                       $175,000
c/o Gund Investment Corporation
14 Nassau Street
Princeton, NJ  08542
Attention:  Mr. Theodore Baker
Telephone:  (609) 921-3633
Facsimile:  (609) 921-7697
---------------------------------------------------------------------------------------------------------------------------------
KBL Healthcare, LP                                               $178,723                117,581                       $178,723
645 Madison Avenue
New York, NY  10022
Attention:  Marlene Krauss
Telephone:  (212) 319-5555
Facsimile:  (212) 319-5591
---------------------------------------------------------------------------------------------------------------------------------
KBL Partnership, LP                                               $21,277                 13,998                        $21,277
645 Madison Avenue
New York, NY  10022
Attention:  Marlene Krauss
Telephone:  (212) 319-5555
Facsimile:  (212) 319-5591
---------------------------------------------------------------------------------------------------------------------------------
Sanderling Venture Partners V Co-Investment Fund, L.P.        $891,040.69                586,211                    $891,040.69
400 S. El Camino Real, Suite 1200
San Mateo, CA  94402
Attention:  Andrew Lenz
Telephone:  (650) 401-2008
Facsimile:  (650) 375-7077
---------------------------------------------------------------------------------------------------------------------------------
Sanderling V Biomedical Co-Investment Fund, L.P.              $540,206.55                355,399                    $540,206.55
400 S. El Camino Real, Suite 1200
San Mateo, CA  94402
Attention:  Andrew Lenz
Telephone:  (650) 401-2008
Facsimile:  (650) 375-7077
---------------------------------------------------------------------------------------------------------------------------------
Sanderling V Limited Partnership                              $145,705.71                 95,859                    $145,705.71
400 S. El Camino Real, Suite 1200
San Mateo, CA  94402
Attention:  Andrew Lenz
Telephone:  (650) 401-2008
Facsimile:  (650) 375-7077
---------------------------------------------------------------------------------------------------------------------------------
Sanderling V Beteiligungs GmbH & Co. KG                       $123,047.05                 80,952                    $123,047.05
400 S. El Camino Real, Suite 1200
San Mateo, CA  94402
Attention:  Andrew Lenz
Telephone:  (650) 401-2008
Facsimile:  (650) 375-7077
---------------------------------------------------------------------------------------------------------------------------------
</TABLE>

                                       24
<PAGE>

                                    EXHIBIT A

                                  FORM OF NOTE

<PAGE>

                                    EXHIBIT B

                                 FORM OF WARRANT

<PAGE>

                                    EXHIBIT C

                           FORM OF OPINION OF COUNSEL

<PAGE>

                                    EXHIBIT D

                           FORM OF SECURITY AGREEMENT

<PAGE>

                                    EXHIBIT E

                FORM OF INTELLECTUAL PROPERTY SECURITY AGREEMENT

<PAGE>

                                    EXHIBIT F

                             POST CLOSING DELIVERIES

<TABLE>
<CAPTION>
-------------------------------------------------------------------------------------
ACTION/DELIVERABLE                                DATE TO BE COMPLETED OR PERFORMED
-------------------------------------------------------------------------------------
<S>                                               <C>
1.  Execution and delivery of an account          September 29, 2002
control agreement with respect to the
securities accounts of the Company at UBS
PaineWebber, in form and substance
reasonably satisfactory to the Majority
Purchasers, providing for control over
such account by the Purchasers.

The Company acknowledges and agrees that
until such control agreement shall have been
executed it shall not transfer any funds
(including the proceeds of the Notes) to the
securities account at UBS PaineWebber.
-------------------------------------------------------------------------------------
2. Delivery of insurance certificates, in form    September 29, 2002
and substance reasonably satisfactory to the
Majority Purchasers, evidencing the Purchasers
as additional insured and loss payees with
respect to the Company's insurance policies, as
required by the Security Agreement.
-------------------------------------------------------------------------------------
3.  Delivery of original share certificates in    October 4, 2002
respect of the Company's shareholdings in
Visionex Pte. Ltd., together with stock powers
(and equivalent Singaporean documents)
executed in blank).
-------------------------------------------------------------------------------------
</TABLE><PAGE>
                                                                   EXHIBIT 10.33

                           ISTA PHARMACEUTICALS, INC.

                   COMMON STOCK AND WARRANT PURCHASE AGREEMENT

                               SEPTEMBER 19, 2002

<PAGE>

                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
                                                                                              PAGE
                                                                                              ----
<S>                                                                                           <C>
Section 1 Definitions............................................................................1

Section 2 Purchase and Sale of the Common Shares and Warrants...................................11

        2.1    Purchase and Sale of the Common Shares and Warrants at the Closing...............11
        2.2    Legends; Stop Transfer Orders....................................................12

Section 3 Representations and Warranties of the Company.........................................13

        3.1    Organization; Qualification......................................................13
        3.2    Subsidiaries and Affiliates......................................................13
        3.3    Capitalization...................................................................14
        3.4    Authorization, Validity of Agreement, Company Action.............................15
        3.5    Vote Required....................................................................15
        3.6    Consents and Approvals, No Violations............................................15
        3.7    Reports and Financial Statements.................................................15
        3.8    Books and Records................................................................16
        3.9    No Undisclosed Liabilities.......................................................16
        3.10   Interim Operations...............................................................17
        3.11   Absence of Certain Changes.......................................................17
        3.12   Litigation.......................................................................19
        3.13   Employee Benefit Plans...........................................................20
        3.14   Tax Matters......................................................................22
        3.15   Title to Properties; Encumbrances................................................23
        3.16   Leases...........................................................................23
        3.17   Environmental Laws...............................................................24
        3.18   Intellectual Property............................................................24
        3.19   Employment Matters...............................................................27
        3.20   Compliance with Laws.............................................................28
        3.21   Contracts and Commitments........................................................28
        3.22   Regulatory Compliance............................................................29
        3.23   Studies..........................................................................31
        3.24   Rights Agreement; Delaware 203 Approval..........................................31
        3.25   Absence of Questionable Payments.................................................32
        3.26   Insider Interests................................................................32
        3.27   Brokers or Finders...............................................................32

Section 4 Representations, Warranties and Covenants of the Investors............................32

        4.1    Authorization....................................................................32
</TABLE>

                                                                             -i-
<PAGE>

                                TABLE OF CONTENTS
                                  (CONTINUED)

<TABLE>
<CAPTION>
                                                                                              PAGE
                                                                                              ----
<S>                                                                                           <C>
        4.2    Investment Experience............................................................32
        4.3    Investment Intent................................................................33
        4.4    Registration or Exemption Requirements...........................................33
        4.5    No Legal, Tax or Investment Advice...............................................33

Section 5 Conditions to Closing of the Investors................................................33

        5.1    Conditions to Investors' Obligations at the Closing..............................33

Section 6 Conditions to Company's Obligations...................................................35

        6.1    Conditions to Company's Obligations at the Closing...............................35

Section 7 Covenants of the Company..............................................................36

        7.1    Registration Rights..............................................................36
        7.2    Reports Under Securities Exchange Act of 1934....................................42
        7.3    Assignment of Rights.............................................................42
        7.4    Stockholders' Meeting............................................................42
        7.5    Proxy Statement..................................................................43
        7.6    Election of Directors............................................................43
        7.7    Nasdaq Listing...................................................................45
        7.8    Purchase in Event of No Stockholder Approval.....................................45
        7.9    Financial Results................................................................46
        7.10   Lock-Up..........................................................................46
        7.11   D&O Insurance....................................................................46
        7.12   Indemnification Agreements.......................................................46
        7.13   Board of Directors; Powers; Committees...........................................46
        7.14   Board Observers..................................................................48
        7.15   Indemnification..................................................................49
        7.16   Operation of Business............................................................49
        7.17   No-Solicitation..................................................................50
        7.18   Reasonable Efforts; Notification; Representations................................50
        7.19   Termination......................................................................51

Section 8 Termination...........................................................................51

        8.1    Termination Events...............................................................51
        8.2    Effect of Termination............................................................52

Section 9 Miscellaneous.........................................................................52

        9.1    Waivers and Amendments...........................................................52
        9.2    Governing Law....................................................................52
        9.3    Waiver of Jury Trial; Trial Costs................................................52
        9.4    Survival.........................................................................52
</TABLE>

                                                                            -ii-
<PAGE>

                                TABLE OF CONTENTS
                                  (CONTINUED)

<TABLE>
<CAPTION>
                                                                                              PAGE
                                                                                              ----
<S>                                                                                           <C>
        9.5    Successors and Assigns...........................................................52
        9.6    Entire Agreement.................................................................53
        9.7    Notices, etc.....................................................................53
        9.8    Interpretation...................................................................53
        9.9    Severability of this Agreement...................................................54
        9.10   Counterparts.....................................................................54
        9.11   Further Assurances...............................................................54
        9.12   Public Announcements.............................................................54
        9.13   Expenses.........................................................................54
        9.14   California Commissioner of Corporations..........................................55
</TABLE>

        Exhibit A     Schedule of Investors
        Exhibit B     Form of Warrant
        Exhibit C     Opinion of Company Counsel
        Exhibit D     Amended and Restated Certificate of Incorporation
        Exhibit E     Form of Indemnification Agreement

                                                                           -iii-

<PAGE>

                           ISTA PHARMACEUTICALS, INC.

                   COMMON STOCK AND WARRANT PURCHASE AGREEMENT

        This Agreement (the "Agreement") is made as of September 19, 2002 by and
among ISTA Pharmaceuticals, Inc., a Delaware corporation (the "Company"), and
those investors listed on Exhibit A hereto (the "Investors").

                                     Recital

        In order to induce the Investors to enter into this Agreement and to
consummate the Transactions, concurrently with the execution and delivery of
this Agreement, certain stockholders, directors and officers of the Company are
executing voting agreements in favor of the Investors.

                                    Section 1

                                   Definitions

        "AcSentient" has the meaning ascribed to it in Section 5.1(i).

        "AcSentient Agreement" has the meaning ascribed to it in Section 5.1(i).

        "Acquisition Proposal" has the meaning set forth in Section 7.17.

        "Action or Proceeding" has the meaning set forth in Section 7.15.

        "Affiliate" shall have the meaning set forth in Rule 12b-2 of the rules
and regulations promulgated under the Exchange Act; provided, however, that for
purposes of this Agreement, (i) the Investors and their respective Affiliates,
on the one hand, and the Company and its Affiliates, on the other, shall not be
deemed to be Affiliates of one another, and (ii) none of the Investor Groups
shall be deemed to be an Affiliate of any other Investor Group.

        "Aggregate Purchase Price" has the meaning ascribed to it in Section
2.1(a)(i).

        "Agreement" has the meaning ascribed to it in the forepart of this
Agreement.

        "Appointment Time" means the time any director is appointed or elected
to the Company's board of directors pursuant to Section 7.6.

        "Associate" has the meaning set forth in Rule 12b-2 of the Exchange Act.

        "Balance Sheet" means the most recent unaudited consolidated balance
sheet of the Company and its Subsidiaries included in the Financial Statements.

<PAGE>

        "Balance Sheet Date" means June 30, 2002, the date of the Balance Sheet.

        "Beneficially Own" or "Beneficial Ownership" shall have the meaning set
forth in Rules 13d-3 and 13d-5 of the rules and regulations promulgated under
the Exchange Act.

        "Benefit Plan" means any employee benefit fund, plan, program,
arrangement or contract (including any "pension" plan, fund or program, as
defined in Section 3(2) of ERISA, and any "employee benefit plan", as defined in
Section 3(3) of ERISA and any plan, program, arrangement or contract providing
for severance; medical, dental or vision benefits; life insurance or death
benefits; disability benefits, sick pay or other wage replacement; vacation,
holiday or sabbatical; pension or profit-sharing benefits; stock options or
other equity compensation; bonus or incentive pay or other material fringe
benefits), whether written or not.

        "Board Consent" has the meaning ascribed to it in Section 3.24.

        "Bridge Effectiveness Termination Date" has the meaning ascribed to it
in Section 7.1(a)(i).

        "Bridge Investor" has the meaning ascribed to it in Section 7.1(a)(i).

        "Bridge Loan Agreement" means the Note and Warrant Purchase Agreement,
dated as of the date of this Agreement, by and among certain of the Investors
and the Company, pursuant to which the Company shall issue Bridge Notes and
Bridge Warrants to such Investors on the terms and subject to the conditions set
forth therein.

        "Bridge Notes" means the promissory notes issued pursuant to the Bridge
Loan Agreement.

        "Bridge Registrable Securities" means shares of Common Stock issued upon
conversion of the Bridge Notes and issued or issuable upon exercise of the
Bridge Warrants, and any other shares of Common Stock issued as (or issuable
upon conversion or exercise of any warrant, right or other security which is
issued as) a dividend or other distribution with respect to, in exchange for or
in replacement of such shares.

        "Bridge Registration Statement" has the meaning ascribed to it in
Section 7.1(a)(i).

        "Bridge Warrants" means the warrants issued pursuant to the Bridge Loan
Agreement.

        "Business Day" means any day other than a Saturday, a Sunday or a day on
which commercial banks in The City of New York are (or are permitted or required
by law, rule, regulation, order or state of emergency to be) closed.

        "Clarifying Request" has the meaning set forth in Section 7.17.

        "Class I Director", "Class II Director" or "Class III Director" has the
meaning ascribed to it in the Company's amended and restated certificate of
incorporation in effect as of the date of this Agreement.

                                                                             -2-
<PAGE>

        "Closing" means the closing referred to in Section 2.1(b).

        "Closing Date" has the meaning ascribed to it in Section 2.1(b).

        "Common Shares" has the meaning ascribed to it in Section 2.1(a)(i).

        "Common Stock" means shares of the Common Stock of the Company.

        "Company" has the meaning ascribed to it in the forepart of this
Agreement.

        "Company Agreement" means any note, bond, mortgage, indenture, lease,
license, contract, agreement, arrangement, or other instrument or obligation to
which the Company or any of its Subsidiaries is a party or by which any of them
or any of their properties or assets may be bound.

        "Company Copyrights" means all Copyrights owned by the Company or any of
its Subsidiaries as of the date of this Agreement.

        "Company Disclosure Schedule" means the disclosure letter, dated the
date of this Agreement, prepared and signed by the Company and delivered to the
Investors simultaneously with the execution of this Agreement.

        "Company ERISA Affiliate" means any other person or entity under common
control with the Company within the meaning of Sections 414(b) or (c) of the
Code.

        "Company ESPP" has the meaning ascribed to it in Section 3.3(a).

        "Company Intellectual Property" means all Intellectual Property owned by
the Company or any of its Subsidiaries as of the date of this Agreement.

        "Company Material Adverse Effect" means any circumstance affecting,
change in, or effect on the Company and its Subsidiaries that is, or imminently
will be, materially adverse to the business, properties, assets, liabilities
(absolute, accrued, or contingent), operations, or results of operation of the
Company and its Subsidiaries, taking the Company together with its Subsidiaries
as a whole, provided, that none of the following shall be deemed, in themselves,
either alone or in combination, to constitute a Company Material Adverse Effect,
and none of the following shall be taken into account in determining whether
there has been or will be a Company Material Adverse Effect: (a) any change in
the market price or trading volume of the Common Stock after the date of this
Agreement; (b) any adverse circumstance, change or effect resulting directly
from conditions affecting the industries in which the Company participates in
their entirety, the U.S. economy as a whole, or foreign economies as a whole in
any countries where the Company or any of its Subsidiaries has material
operations or is conducting clinical trials; (c) any adverse circumstance,
change or effect resulting directly from the announcement or pendency of this
Agreement, the Stockholders' Meeting or the Closing (including any termination
or breach of supplier, distributor, partner or similar relationships); (d) any
failure by the Company to meet internal, non-public

                                                                             -3-
<PAGE>

projections or forecasts (other than the financial results set forth in Section
7.9 and the Forecast); (e) the Company's actual reasonable investment banking
and legal fees in respect of this Agreement and the other agreements and
transactions contemplated hereby and thereby, to the extent such fees do not
exceed the amounts of investment banking and legal fees set forth in Section
3.27 of the Disclosure Schedule; (f) any adverse circumstance, change or effect
resulting directly from the taking of any action by the Company which this
Agreement requires the Company to take; (g) any adverse circumstance, change or
effect resulting directly from a failure by the Investors to provide any funding
to the Company in violation of the Bridge Loan Agreement; (h) any adverse
circumstance, change or effect resulting directly from action by any Regulatory
Authority, including the FDA, other than any adverse circumstance, change or
effect resulting directly from the refusal of the FDA to file the Company's
submissions for clinical or safety issues; (i) any adverse circumstance, change
or effect resulting directly from any failure by the Company to pay any of its
obligations to its creditors within 60 days of the date that such obligations
become due and payable; or (j) any delisting of the Common Stock from Nasdaq.

        "Company Option" means any right or option to purchase shares of the
Company's Common Stock which is granted by the Company's board of directors and
is outstanding as of the date of this Agreement.

        "Company Patents" means all Patents owned by the Company or any of its
Subsidiaries as of the date of this Agreement.

        "Company SEC Documents" means each form, report, schedule, statement and
other document filed or required to be filed by the Company since August 25,
2000 through the date of this Agreement under the Exchange Act or the Securities
Act, including any filed amendment to such document, whether or not such
amendment is required to be so filed.

        "Company's knowledge," "the knowledge of the Company," "the knowledge of
the Company and its Subsidiaries" and similar phrases incorporating the word
"know" or "known" mean, with respect to any matter in question, actual knowledge
of such matter held by any member of the board of directors or any officer or
vice president of the Company or any of its Subsidiaries.

        "Company Trademarks" means all Trademarks owned by the Company or any of
its Subsidiaries as of the date of this Agreement.

        "Company Trade Secrets" means all Trade Secrets owned by the Company or
any of its Subsidiaries as of the date of this Agreement.

        "Confidential Information" has the meaning ascribed to it in Section
7.14.

        "Consent of the Investors" means the consent of the Investors entitled
to purchase more than 90% of the Investor Shares. Such consent shall be
effective upon the later of (i) written consent of the Investors having the
right to purchase at least 90% of the Investor Shares pursuant to Section 2.1
herein and (ii) 2 Business Days after notice of such consent has been received
by the controlling

                                                                             -4-
<PAGE>

Affiliate of each Investor Group that has not delivered such written consent;
provided that such consent shall not be binding upon an Investor and this
Agreement shall terminate solely with respect to such Investor, subject to
Section 8.2 herein, upon receipt by the Company and each other Investor of
notice of termination by the Investor pursuant to Section 8.1(e) herein.

        "Convertible Securities" shall mean any securities of the Company which
are convertible into, exchangeable for or otherwise exercisable to acquire
Voting Stock of the Company, including convertible securities, warrants, rights
or options to purchase Voting Stock of the Company.

        "Copyrights" means U.S. and foreign registered and unregistered
copyrights (including those in computer software and databases), moral rights,
rights of publicity and all registrations and applications to register the same.

        "Defect" means a defect or impurity of any kind, whether in design,
manufacture, processing, or otherwise, including any dangerous propensity
associated with any reasonably foreseeable use of a Product, or the failure to
warn of the existence of any defect, impurity, or dangerous propensity.

        "DGCL" means the General Corporation Law of the State of Delaware.

        "Effectiveness Termination Date" means the Bridge Effectiveness
Termination Date or the PIPE Effectiveness Termination Date, as the case may be.

        "Environmental Claim" means any claim, action, investigation or notice
by any Person or entity alleging potential liability for investigatory, cleanup
or governmental response costs, or natural resources or property damages, or
personal injuries, attorney's fees or penalties relating to (i) the presence, or
release into the environment, of any Materials of Environmental Concern at any
location owned or operated by the Company or any of its Subsidiaries, now or in
the past, or (ii) any violation, or alleged violation, of any Environmental Law.

        "Environmental Law" means each federal, state, local and foreign law and
regulation relating to pollution, protection or preservation of the environment,
human health or occupational health and safety, including ambient air, surface
water, groundwater, land surface or subsurface strata, and natural resources,
and including each law and regulation relating to emissions, discharges,
releases or threatened releases of Materials of Environmental Concern, or
otherwise relating to the generation, storage, containment (whether above ground
or underground), disposal, transport or handling of Materials of Environmental
Concern, and each law and regulation with regard to record keeping,
notification, disclosure and reporting requirements respecting Materials of
Environmental Concern, except to the extent relating to laws enforced by the
FDA.

        "ERISA" means the Employee Retirement Income Security Act of 1974, as
amended.

        "Exchange Act" means the Securities Exchange Act of 1934, as amended,
and the applicable rules and regulations of the SEC promulgated thereunder.

                                                                             -5-
<PAGE>

        "FDA" means the United States Food and Drug Administration or any
successor agency.

        "Financial Advisor" means Thomas Weisel Partners.

        "Financial Statements" means each of the audited consolidated financial
statements and unaudited condensed consolidated interim financial statements of
the Company (including any related notes and schedules) included (or
incorporated by reference) in the Company SEC Documents.

        "Forecast" has the meaning ascribed to it in Section 7.9.

        "Fully Diluted Shares" means the shares of Common Stock issued and
outstanding and the shares of Common Stock issuable upon conversion of any
convertible security and upon exercise of any warrant, including the Warrants,
the Bridge Notes, and the Bridge Warrants.

        "GAAP" means United States generally accepted accounting principles.

        "Governmental Entity" means a court, arbitral tribunal, Regulatory
Authority, administrative agency, commission or other governmental or other
regulatory authority or agency, or any Person exercising the authority of any of
the foregoing.

        "HSR Act" means the Hart-Scott-Rodino Antitrust Improvements Act of
1976, as amended.

        "IGC" has the meaning ascribed to it in Section 7.6(b).

        "IGC Designee" has the meaning ascribed to it in Section 7.6(b).

        "Indemnification Agreement" has the meaning ascribed to it in Section
7.12.

        "Indemnified Party" has the meaning ascribed to it in Section
7.1(d)(iii).

        "Indemnifying Party" has the meaning ascribed to it in Section
7.1(d)(iii).

        "Inbound License Agreement" has the meaning ascribed to it in Section
3.18(e).

        "IND" has the meaning ascribed to it in Section 3.22(c).

        "Intellectual Property" means all of the following: Trademarks, Patents,
Copyrights and Trade Secrets.

        "Internal Revenue Code" means the Internal Revenue Code of 1986, as
amended.

        "Investor Counsel" has the meaning ascribed to it in Section 7.1(c)(ix).

                                                                             -6-
<PAGE>

        "Investor Groups" means (a) Dionis Trust, Grant Gund 1978 Trust, G.
Zachary Gund 1978 Trust, Grant Owen Gund Gift Trust, Llura Blair Gund Gift
Trust, Anna Barrows Beakey 1998 Trust, Katharine Barrows Dadagian 1998 Trust or
any of their Affiliates (collectively, the "Gund Trusts"), (b) KBL Healthcare,
LP, KBL Partnership, LP., or any of their Affiliates (collectively, "KBL"), (c)
Sanderling Venture Partners V Co-Investment Fund, L.P., Sanderling V Biomedical
Co-Investment Fund, L.P., Sanderling V Limited Partnership, Sanderling V
Beteiligungs GmbH & Co. KG, Sanderling V Ventures Management, Ontario Teachers
Pension Plan, CDP Capital or any of their Affiliates, (d) Investor Growth
Capital Limited, Investor Group L.P. or any of their Affiliates and (e) Sprout
Capital IX, L.P., Donaldson, Lufkin & Jenrette Securities Corporation, Sprout
Entrepreneurs Fund, L.P. or any of their Affiliates.

        "Investor Indemnitees" has the meaning ascribed to it in Section 7.15.

        "Investor Shares" means the Fully Diluted Shares held by all Investors
and their respective Affiliates at the time of determining whether there is
Consent of the Investors or, if the Closing has not occurred as of such time,
the Fully Diluted Shares that would be outstanding assuming the Closing had
occurred immediately prior to such time.

        "Investors" has the meaning ascribed to it in the forepart of the
Agreement.

        "Investors' Agents" has the meaning ascribed to it in Section 7.1(d)(i).

        "IRS" means the United States Internal Revenue Service and any successor
agency performing similar functions under the Internal Revenue Code.

        "Licenses" means all licenses and agreements pursuant to which the
Company has acquired rights in or to any Trademarks, Patents, or Copyrights, or
licenses and agreements pursuant to which the Company has licensed or
transferred rights to use any of the foregoing.

        "Lock-Up Period" has the meaning ascribed to it in Section 7.10.

        "Materials of Environmental Concern" means any material or substance
that is designated by a governmental authority to be radioactive, toxic or
hazardous including petroleum products, asbestos and asbestos-containing
materials, polychlorinated biphenyls, radon and lead or lead-based paints and
materials.

        "NASD Rules" means the rules and regulations adopted by the National
Association of Securities Dealers, Inc. concerning Nasdaq listed companies.

        "Nasdaq" shall mean the Nasdaq Stock Market.

        "NDA" has the meaning ascribed to it in Section 3.22(c).

        "Non-Approval Event" has the meaning ascribed to it in Section 7.8.

                                                                             -7-
<PAGE>

        "Observers" has the meaning ascribed to it in Section 7.14.

        "Outbound License Agreements" has the meaning ascribed to it in Section
3.18(e).

        "Patents" means issued U.S. and foreign patents and pending patent
applications, patent disclosures, and any and all divisions, continuations,
continuations-in-part, reissues, reexaminations, and extension thereof, any
counterparts claiming priority therefrom, utility models, patents of
importation/confirmation, certificates of invention and like statutory rights.

        "PBGC" means the Pension Benefit Guaranty Corporation.

        "Person" means any natural person, corporation, limited liability
company, partnership (general or limited), business trust, joint stock company,
trust, unincorporated association, joint venture, Governmental Entity or other
entity or organization.

        "PIPE Effectiveness Termination Date" has the meaning ascribed to it in
Section 7.1(a)(ii).

        "PIPE Registrable Securities" means the Common Shares, and any other
shares of Common Stock issued or issuable upon exercise of the Warrants, and any
other shares of Common Stock issued as (or issuable upon the conversion or
exercise of any warrant, right or other security which is issued as) a dividend
or other distribution with respect to, or in exchange for or in replacement of
such shares.

        "PIPE Registration Statement" has the meaning ascribed to it in Section
7.1(a)(ii).

        "Product" means any product designed, manufactured, shipped, sold,
marketed, distributed and/or otherwise introduced into the stream of commerce by
or on behalf of the Company or any of its Subsidiaries, including any product
sold in the United States by the Company or any of its Subsidiaries as the
distributor, agent, or pursuant to any other contractual relationship with a
non-U.S. manufacturer, and investigational products.

        "Proxy Statement" has the meaning ascribed to it in Section 7.5(a).

        "Purchase Price" has the meaning ascribed to it in Section 2.1(a)(i).

        "Registrable Securities" means the Bridge Registrable Securities and the
PIPE Registrable Securities.

        "Registration Expenses" has the meaning ascribed to it in Section
7.1(b).

        "Registration Statement" shall mean the Bridge Registration Statement
and the PIPE Registration Statement, as the case may be, including the
prospectus, amendments and supplements to such registration statements,
including post-effective amendments, all exhibits and all materials

                                                                             -8-
<PAGE>

incorporated by reference or explicitly deemed to be incorporated by reference
in such registration statements.

        "Regulatory Authority" means the FDA and any counterpart of the FDA
outside of the United States and other national, supra-national, regional, state
and local regulatory agency, department, bureau, commission, council and other
governmental entity with authority over the clinical testing, manufacture,
storage, distribution, sale and use of drug products.

        "Representative" has the meaning set forth in Section 7.17.

        "Resigning Director" has the meaning ascribed to it in Section 5.1(d).

        "Restated Certificate" has the meaning ascribed to it in Section 5.1(h).

        "Reverse Stock Split" means an amendment to the Company's certificate of
incorporation to effect a reverse stock split of the Common Stock whereby the
Company shall issue one new share of Common Stock in exchange for not less than
7 shares nor more than 10 shares of its outstanding Common Stock, or such other
number of shares of outstanding Common Stock as is mutually agreed upon by the
Company and the Consent of the Investors.

        "Rights Agreement" means the Rights Agreement between the Company and
Mellon Investor Services LLC, dated as of December 31, 2001.

        "Sanderling" has the meaning ascribed to it in Section 7.6(c).

        "Sanderling Designee" has the meaning ascribed to it in Section 7.6(c).

        "SEC" shall mean the U.S. Securities and Exchange Commission (or any
successor thereto).

        "Securities Act" shall mean the Securities Act of 1933, as amended, and
the applicable rules and regulations of the SEC promulgated thereunder.

        "Selling Expenses" has the meaning ascribed to it in Section 7.1(b).

        "Sprout" has the meaning ascribed to it in Section 7.6(a).

        "Sprout Designee" has the meaning ascribed to it in Section 7.6(a).

        "Stockholder Approval" means approval by stockholders holding a majority
of the outstanding Voting Stock present, in person or by proxy, at the
Stockholders' Meeting or any other meeting of the Company's stockholders duly
convened, of: (i) the Transactions, including the sale and issuance of the
Common Shares and the Warrants to the Investors in accordance with the terms of
this Agreement, (ii) conversion of the Bridge Notes at the option of the holders
thereof, (iii) the Reverse Stock Split, (iv) an amendment to the Company's
certificate of incorporation providing for action by written consent of the
stockholders in lieu of a meeting and (v) an amendment to the

                                                                             -9-
<PAGE>

Company's 2000 Stock Plan to increase the number of shares reserved for issuance
thereunder to a number of shares mutually determined by the Company and Consent
of the Investors; provided, however, that subclauses (iv) and (v) above shall be
excluded from the definition of "Stockholder Approval" for purposes of Section
5.1(f), 6.1(b) and 7.8 (a) herein.

        "Stockholders' Meeting" has the meaning ascribed to it in Section 7.4.

        "Subsidiary" means, with respect to any Person, any corporation or other
organization, whether incorporated or unincorporated, of which (a) at least a
majority of the securities or other interests having by their terms ordinary
voting power to elect a majority of the board of directors or others performing
similar functions with respect to such corporation or other organization is,
directly or indirectly, owned or controlled by such Person or by any one or more
of its Subsidiaries, or by such Person and one or more of its Subsidiaries or
(b) such Person or any other Subsidiary of such Person is a general partner or
managing member (excluding any such partnership or limited liability company
where such Person or any Subsidiary of such Person does not have a majority of
the voting interest in such partnership or limited liability company).

        "Tax" and "Taxes" mean all taxes, charges, fees, duties, levies,
penalties or other assessments imposed by any federal, state, local or foreign
governmental authority, including income, gross receipts, excise, property,
sales, gain, use, license, custom duty, unemployment, capital stock, transfer,
franchise, payroll, withholding, social security, minimum estimated, and other
taxes, and shall include interest, penalties or additions attributable thereto.

        "Tax Return" means any return, declaration, report, claim for refund, or
information return or statement relating to Taxes, including any schedule or
attachment thereto, and including any amendment thereof.

        "Title IV Plan" means a Plan that is subject to Section 302 or Title IV
of ERISA or Section 412 of the Internal Revenue Code.

        "Trademarks" means U.S. and foreign registered and unregistered
trademarks, trade dress, service marks, logos, trade names, corporate names and
all registrations and applications to register the same.

        "Trade Secrets" means all: trade secrets; and, to the extent actually
protected as a trade secret under the law, computer software, databases, other
confidential information, technology; know-how, proprietary processes, formulae,
algorithms, models, user interfaces, customer lists, inventions, discoveries,
concepts, ideas, techniques, methods, source codes, object codes, methodologies
and, with respect to all of the foregoing, related confidential data or
information.

        "Transactions" means the transactions contemplated by this Agreement.

                                                                            -10-
<PAGE>

        "Total Current Voting Power" shall mean the total number of votes which
may be cast in the election of members of the board of directors of either the
Company or the surviving corporation of a merger to which the Company is a party
if all securities entitled to vote in the election of such directors (on an
as-converted to Common Stock basis, if applicable) are present and voted.

        "Venture Investors" has the meaning ascribed to it in Section 7.14.

        "Voting Debt" shall mean any indebtedness of the Company having general
voting rights or any debt convertible into securities having such rights.

        "Voting Stock" shall mean shares of Common Stock and any other
securities of the Company having the ordinary power to vote generally in the
election of members of the Company's board of directors.

        "Warrant" has the meaning ascribed to it in Section 2.1(a)(ii).

                                    Section 2

              Purchase and Sale of the Common Shares and Warrants.

        2.1 Purchase and Sale of the Common Shares and Warrants at the Closing.

               (a) Subject to the terms and conditions hereof, each Investor
agrees, severally and not jointly, to purchase at the Closing, and the Company
agrees to sell and issue to each Investor, severally and not jointly, at the
Closing:

                      (i) that number of shares of Common Stock determined by
dividing (A) the dollar amount set forth opposite such Investor's name on
Exhibit A hereto (the "Aggregate Purchase Price") by (B) the per share purchase
price of $0.38 (the "Purchase Price"), and rounded down to nearest whole number
of shares (such shares of Common Stock so purchased, the "Common Shares"); and

                      (ii) a warrant, in the form attached hereto as Exhibit B,
exercisable for that number of shares of Common Stock equal to 15% of the Common
Shares purchased by such Investor pursuant to Section 2.1(a)(i) above, at a per
share exercise price equal to the Purchase Price (each, a "Warrant").

The number of Common Shares to be purchased by the Investors at the Closing
pursuant to Section 2.1(a)(i), and the Purchase Price applicable to such Common
Shares and the Warrants, shall be proportionately adjusted for any subdivision
or combination of Common Stock (by stock split, reverse stock split, dividend,
reorganization, recapitalization or otherwise, including, without limitation,
the Reverse Stock Split).

                                                                            -11-
<PAGE>

               (b) The closing of the purchase and sale of the Common Shares and
the Warrants pursuant to this Agreement (the "Closing") shall take place at
10:00 a.m. at the offices of Wilson Sonsini Goodrich & Rosati, Professional
Corporation, 650 Page Mill Road, Palo Alto, California 94304 on the second
Business Day (the "Closing Date") after satisfaction in full of the closing
conditions set forth in Sections 5 and 6 herein, or waiver of any such closing
conditions pursuant to the terms therein, or at such other time and place as may
be agreed to by the consent of the Company and Consent of the Investors.

               (c) At the Closing, subject to the terms and conditions hereof,
the Company shall deliver to each Investor a Warrant and a certificate
representing the Common Shares purchased by such Investor from the Company,
dated as of the Closing Date, against payment of the full amount of such
Investor's Aggregate Purchase Price by any combination of (i) wire transfer of
immediately available funds to the Company's bank account and/or (ii) upon
receipt of Stockholder Approval, at the election of such Investor, cancellation
of the appropriate amount of indebtedness under such Investor's Bridge Note, and
the Company shall register the issuance and ownership of the Common Shares and
Warrants so purchased in the stockholders' registry and books of the Company.

        2.2 Legends; Stop Transfer Orders.

               (a) All certificates representing the Common Shares and shares of
Common Stock issued or issuable upon exercise of the Warrants shall bear the
following legends:

                      (i) "THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE BEEN
ACQUIRED FOR INVESTMENT AND HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
1933, AS AMENDED (THE "ACT"). SUCH SHARES MAY NOT BE SOLD OR TRANSFERRED IN THE
ABSENCE OF REGISTRATION OR AN EXEMPTION THEREFROM. ISTA PHARMACEUTICALS, INC.
MAY REQUIRE AN OPINION OF COUNSEL REASONABLY ACCEPTABLE TO IT THAT A PROPOSED
TRANSFER OR SALE IS IN COMPLIANCE WITH THE ACT."

                      (ii) "THE SALE, TRANSFER OR VOTING OF THE SHARES
REPRESENTED BY THIS CERTIFICATE IS RESTRICTED BY THE TERMS OF A STOCK PURCHASE
AGREEMENT BY AND BETWEEN ISTA PHARMACEUTICALS, INC. AND THE INVESTOR. COPIES OF
THE AGREEMENT MAY BE OBTAINED AT NO COST BY WRITTEN REQUEST MADE BY THE HOLDERS
OF RECORD OF THIS CERTIFICATE TO THE SECRETARY OF ISTA PHARMACEUTICALS, INC. AT
THE PRINCIPAL EXECUTIVE OFFICES OF ISTA PHARMACEUTICALS, INC."

                      (iii) Any legend required by the blue sky or securities
laws of any state or jurisdiction to the extent such laws are applicable to the
shares represented by the certificate so legended.

                                                                            -12-
<PAGE>

               (b) The certificates representing the Common Shares will be
subject to a stop transfer order with the Company's transfer agent that
restricts the transfer of such shares except in compliance with this Agreement.

               (c) The Company acknowledges and agrees that an opinion of
counsel shall not be required upon the transfer by an Investor of any securities
to an Affiliate of said Investor, except in unusual circumstances.

                                    Section 3

                  Representations and Warranties of the Company

        Except as set forth in the Company Disclosure Schedule, the Company
represents and warrants to each Investor that:

        3.1 Organization; Qualification. The Company (a) is a corporation duly
organized, validly existing and in good standing under the laws of its state of
incorporation; (b) has all requisite corporate power and authority to carry on
its business as it is now being conducted and to own the properties and assets
it now owns; and (c) is duly qualified or licensed to do business as a foreign
corporation in good standing in every jurisdiction in which such qualification
is required except where failure to be so qualified or licensed or in good
standing would not reasonably be expected to have a Company Material Adverse
Effect.

        3.2 Subsidiaries and Affiliates. Section 3.2 of the Company Disclosure
Schedule sets forth the name, jurisdiction of incorporation and authorized and
outstanding capital of each Subsidiary of the Company and the jurisdictions in
which each such Subsidiary is qualified to do business. The Company does not
own, directly or indirectly, any capital stock or other equity securities of any
corporation or have any direct or indirect equity or ownership interest in any
business or other Person, other than publicly traded securities constituting
less than five percent (5%) of the outstanding equity of the issuing entity. All
the outstanding capital stock of each Company Subsidiary is, directly or
indirectly, owned (of record and beneficially) by the Company free and clear of
any liens, options or encumbrances of any kind, restrictions on transfers (other
than restrictions on transfer arising under applicable securities laws), claims
or charges of any kind, and is validly issued, fully paid and nonassessable, and
there is no outstanding option, right or agreement of any kind relating to the
issuance, sale or transfer of any capital stock or other equity securities of
any such Company Subsidiary to any Person except the Company. Each of the
Company's Subsidiaries (a) is a corporation duly organized, validly existing and
in good standing under the laws of its state of incorporation; (b) has all
requisite corporate power and authority to carry on its business as it is now
being conducted and to own the properties and assets it now owns; and (c) is
duly qualified or licensed to do business as a foreign corporation in good
standing in every jurisdiction in which such qualification is required except
where failure to be so qualified or licensed or in good standing would not
reasonably be expected to have a Company Material Adverse Effect.

                                                                            -13-
<PAGE>

        3.3 Capitalization.

               (a) The authorized capital stock of the Company consists of
100,000,000 shares of Common Stock and 5,000,000 shares of preferred stock, par
value $0.001 per share. As of the date of this Agreement, (i) 16,892,636 shares
of Common Stock are issued and outstanding, (ii) no shares of Common Stock are
issued and held in the treasury of the Company, (iii) 1,000,000 shares of
preferred stock are designated as Series A Participating Preferred Stock, none
of which are issued and outstanding, (iv) 3,400,000 shares of Common Stock are
reserved for issuance upon exercise of Company Options under the Company's 1993
Stock Plan, (v) 600,000 shares of Common Stock are reserved for issuance upon
exercise of Company Options under the Company's 2000 Stock Plan, and (vi)
600,000 shares of Common Stock are reserved for issuance pursuant to the
Company's 2000 Employee Stock Purchase Plan (the "Company ESPP"). Section 3.3(a)
of the Company Disclosure Schedule lists, as of the date hereof, the holder of
each outstanding Company Option, the number of shares of Common Stock for which
such Company Option is exercisable, the exercise price of such Company Option,
the extent to which such Company Option will vest upon consummation of any of
the Transactions and the vesting schedule of such Company Option. All the
outstanding shares of the Company's capital stock are, and all shares of Common
Stock which may be issued pursuant to the exercise of outstanding Company
Options will be, when issued in accordance with the respective terms thereof,
duly authorized, validly issued, fully paid and nonassessable. There is no
Voting Debt of the Company or any of its Subsidiaries issued and outstanding.
Except as set forth above and except for the Transactions and as contemplated by
the Bridge Loan Agreement, as of the date hereof, (x) there is no capital stock
of the Company authorized, issued or outstanding; (y) there is no existing
option, warrant, call, pre-emptive right, subscription or other right,
agreement, arrangement, understanding or commitment of any character, relating
to the issued or unissued capital stock of the Company or any of its
Subsidiaries, obligating the Company or any of its Subsidiaries to issue,
transfer or sell or cause to be issued, transferred or sold any shares of
capital stock or Voting Debt of, or other equity interest in, the Company or any
of its Subsidiaries or securities convertible into or exchangeable for such
shares, equity interests or Voting Debt, or obligating the Company or any of its
Subsidiaries to grant, extend or enter into any such option, warrant, call,
subscription or other right, agreement, arrangement or commitment; and (z) there
is no outstanding contractual obligation of the Company or any of its
Subsidiaries to repurchase, redeem or otherwise acquire any shares of Common
Stock, or the capital stock of the Company, or any Company Subsidiary or
Affiliate of the Company or to provide funds to make any investment (in the form
of a loan, capital contribution or otherwise) in any Company Subsidiary or any
other Person. With respect to any exception to the contractual obligations of
the Company set forth in Section 3.3(a) of the Company Disclosure Schedule, the
schedule completely and correctly identifies the parties to such obligations and
the nature of any relationship of such party.

               (b) There is no voting trust or other agreement or understanding
to which the Company or any of its Subsidiaries is a party with respect to the
voting of the capital stock of the Company or any of its Subsidiaries.

                                                                            -14-
<PAGE>

               (c) No indebtedness of the Company or any of its Subsidiaries
contains any restriction upon (i) the prepayment of any indebtedness of the
Company or any of its Subsidiaries, (ii) the incurrence of indebtedness by the
Company or any of its Subsidiaries or (iii) the ability of the Company or any of
its Subsidiaries to grant any lien on the properties or assets of the Company or
any of its Subsidiaries.

        3.4 Authorization, Validity of Agreement, Company Action. The Company
has all requisite corporate power and authority to execute and deliver this
Agreement and the Warrants, to perform its obligations under this Agreement and
the Warrants and to consummate the Transactions. The execution and delivery of
this Agreement by the Company and the performance by the Company of its
obligations under this Agreement and the consummation by the Company of the
Transactions, have been duly authorized by the Company's board of directors and,
except for obtaining Stockholder Approval as contemplated by Section 7.4, no
other corporate action on the part of the Company or its stockholders is
necessary to authorize the execution and delivery by the Company of this
Agreement or the Warrants or the consummation by it of the Transactions. This
Agreement and, as of the Closing, the Warrants, have been duly executed and
delivered by the Company and, this Agreement, assuming due and valid
authorization, execution and delivery hereof by the Investors, is and, as of the
Closing, the Warrants will be valid and binding obligations of the Company
enforceable against the Company in accordance with its and their respective
terms.

        3.5 Vote Required. The affirmative vote of the holders of a simple
majority of the outstanding shares of Common Stock present in person or by proxy
at a meeting of the Company's stockholders duly convened is the only vote of the
holders of any class or series of the Company's capital stock necessary to
approve the Transactions. No separate vote of any class or series of the
Company's capital stock is necessary to approve the Transactions.

        3.6 Consents and Approvals, No Violations. Except for the filings,
permits, authorizations, consents, notices, and approvals as may be required
under, and other applicable requirements of, the Exchange Act, state securities
or blue sky laws, none of the execution, delivery or performance of this
Agreement by the Company, the consummation by the Company of the Transactions or
compliance by the Company with any of the provisions of this Agreement will (a)
conflict with or result in any breach of any provision of the certificate of
incorporation, the by-laws or similar organizational documents of the Company or
any of its Subsidiaries, (b) require any material filing with, or permit,
authorization, consent or approval of, any Governmental Entity, (c) result in a
material violation or breach of, or constitute (with or without due notice or
the passage of time or both) a default (or give rise to any right of
termination, amendment, cancellation or acceleration or loss of any rights)
under, any of the terms, conditions or provisions of any Company Agreement or
(d) violate any order, writ, injunction, decree, or any material statute, rule
or regulation applicable to the Company, any Company Subsidiary or any of their
material properties or assets.

        3.7 Reports and Financial Statements.

               (a) The Company has filed with the SEC the Company SEC Documents.
As of their respective dates (or, if amended or superseded, as of the date of
the last such amendment or

                                                                            -15-
<PAGE>

superseding report filed prior to the date of this Agreement), the Company SEC
Documents, including any financial statements or schedules included therein (a)
did not contain any untrue statement of a material fact or omit to state a
material fact required to be stated therein or necessary in order to make the
statements made therein, in the light of the circumstances under which they were
made, not misleading and (b) complied in all material respects with the
applicable requirements of the Exchange Act and the Securities Act, as the case
may be, and the applicable rules and regulations of the SEC thereunder. The
Chief Executive Officer and the Chief Financial Officer of the Company have
signed, and the Company has furnished to the SEC, all certifications required by
Section 906 of the Sarbanes-Oxley Act of 2002; such certifications contain no
qualifications or exceptions to the matters certified therein and have not been
modified or withdrawn; and neither the Company nor any of it officers has
received notice from any Governmental Entity questioning or challenging the
accuracy, completeness, form or manner of filing or submission of such
certifications. None of the Company's Subsidiaries is required to file any
forms, reports or other documents with the SEC.

               (b) Each of the Financial Statements has been prepared from, and
are in accordance with, the books and records of the Company and its
Subsidiaries. The Financial Statements complied, as of their respective dates,
in all material respects with applicable accounting requirements and rules and
regulations of the SEC. The Financial Statements have been prepared in
accordance with GAAP applied on a consistent basis (except as may be indicated
in the notes thereto and subject, in the case of interim condensed consolidated
financial statements, to normal, recurring and year-end adjustments which were
not and are not expected to be material in amount and the absence of certain
notes) and fairly present in all material respects as of their respective dates
(i) the consolidated financial position of the Company and its Subsidiaries as
of the dates thereof and (ii) the consolidated results of operations, changes in
stockholders equity and cash flows of the Company and its Subsidiaries for the
periods presented therein.

        3.8 Books and Records. The books of account, minute books, stock record
books and other records of the Company and its Subsidiaries are complete and
correct in all material respects and have been maintained in accordance with
sound business practices and the requirements of Section 13(b)(2) of the
Exchange Act, including an adequate system of internal controls. The minute
books of the Company contain accurate and complete records of all meetings held
of, and corporate action taken by, the stockholders, the Company's board of
directors and committees of the Company's board of directors, and no meeting of
any of such stockholders, the Company's board of directors or such committees
has been held for which minutes have not been prepared and are not contained in
such minute books.

        3.9 No Undisclosed Liabilities. Except (a) as disclosed in the Financial
Statements, (b) for liabilities disclosed in the Company SEC Documents, and (c)
for liabilities and obligations incurred in the ordinary course of business and
consistent with past practice since the Balance Sheet Date, neither the Company
nor any of its Subsidiaries has any material liability or obligation of any
nature, whether or not accrued, contingent or otherwise that would be required
by GAAP to be disclosed on a consolidated balance sheet of the Company or in the
notes thereto. The Company has

                                                                            -16-
<PAGE>

not created any entities or entered into any transactions or created any
liabilities or obligations of any nature, whether or not accrued, contingent or
otherwise, for the purpose of avoiding disclosure required by GAAP.

        3.10 Interim Operations. Since the Balance Sheet Date, the business of
the Company and each of its Subsidiaries has been conducted only in the ordinary
and usual course consistent with past practice. Since the date of the Balance
Sheet, there has not been any Company Material Adverse Effect.

        3.11 Absence of Certain Changes. Since the Balance Sheet Date, neither
the Company nor any of its Subsidiaries has:

               (a) suffered any Company Material Adverse Effect;

               (b) incurred any liabilities or obligations (absolute, accrued,
contingent or otherwise) except non-material items incurred in the ordinary
course of business and consistent with past practice, none of which exceeds one
hundred fifty thousand dollars ($150,000) (counting obligations or liabilities
arising from one transaction or a series of similar transactions, and all
periodic installments or payments under any lease or other agreement providing
for periodic installments or payments, as a single obligation or liability), or
increased, or experienced any change in any assumptions underlying or methods of
calculating, any bad debt, contingency or other reserves or allowances;

               (c) paid, discharged or satisfied any claim, liability or
obligation (whether absolute, accrued, contingent or otherwise) other than the
payment, discharge or satisfaction in the ordinary course of business and
consistent with past practice of liabilities and obligations reflected or
reserved against in the Balance Sheet or incurred in the ordinary course of
business and consistent with past practice since the Balance Sheet Date;

               (d) permitted or allowed any of its material properties or assets
(real, personal or mixed, tangible or intangible) to be subjected to any
mortgage, pledge, claim, lien, security interest, encumbrance, restriction or
charge of any kind, except for liens for current Taxes not yet due;

               (e) cancelled any debt or waived any claim or right of
substantial value;

               (f) sold, transferred, licensed, leased, pledged, mortgaged or
otherwise disposed of any of its material properties or assets (real, personal
or mixed, tangible or intangible) or any material amount of property or assets,
except in the ordinary course of business;

               (g) disposed of or permitted to lapse any right to the use of any
Intellectual Property, or disposed of or disclosed to any Person, other than
representatives of the Investors and Persons subject to a nondisclosure
agreement, any trade secret, formula, process, know-how or other Intellectual
Property and not yet a matter of public knowledge;

                                                                            -17-
<PAGE>

               (h) granted any material increase or accrual in or accelerated,
any benefit or compensation payable or to become payable to any officer,
director, employee or consultant, including any such increase, accrual or
acceleration pursuant to any Benefit Plan except in connection with a promotion
or job change or any general increase in the compensation payable or to become
payable to officers, employees or directors in the ordinary course of business,
or entered into or amended in any material way any employment, material
consulting, severance, termination or material Benefit Plan agreement or
arrangement;

               (i) made any single capital expenditure or commitment in excess
of fifty thousand dollars ($50,000) for additions to property, plant, equipment
or intangible capital assets or made aggregate capital expenditures and
commitments in excess of fifty thousand dollars ($50,000) (on a consolidated
basis) for additions to property, plant, equipment or intangible capital assets;

               (j) declared, paid or set aside for payment any dividend or other
distribution in respect of its capital stock or redeemed, purchased or otherwise
acquired, directly or indirectly, any shares of capital stock or other
securities of the Company or any of its Subsidiaries;

               (k) made any change in any method of Tax or GAAP accounting or
accounting practice that would or would reasonably be expected to result in any
material change in the Financial Statements;

               (l) paid, loaned or advanced any amount to, or sold, transferred
or leased any material properties or assets (real, personal or mixed, tangible
or intangible) to, or entered into any agreement or arrangement with, any of its
officers or directors or employees or any Affiliate or Associate of any of its
officers or directors or employees, except for directors' fees, and compensation
to officers at rates not exceeding the rates of compensation paid during the
year ended December 31, 2001;

               (m) except as expressly required by this Agreement, (i) amended
its certificate of incorporation or by-laws or similar organizational documents,
(ii) issued, sold, transferred, pledged, disposed of or encumbered any shares of
any class or series of its capital stock or Voting Debt, or securities
convertible into or exchangeable for, or options, warrants, calls, commitments
or rights of any kind to acquire, any shares of any class or series of its
capital stock or any Voting Debt, other than shares of Common Stock reserved for
issuance on the date of this Agreement pursuant to the Company's Employee Stock
Purchase Plan, the exercise of any options to purchase Common Stock outstanding
on the date of this Agreement or existing agreements that require the Company to
issue shares of Common Stock, or (iii) redeemed, purchased or otherwise acquired
directly or indirectly any shares of any class or series of its capital stock,
or any instrument or security which consists of or includes a right to acquire
such shares (other than repurchases of restricted stock at cost required
pursuant to agreements outstanding on the date of this Agreement or entered into
after the date of this Agreement in compliance with the provisions hereof);

                                                                            -18-
<PAGE>

               (n) terminated or materially modified or amended any of its
material contracts or waived, released or assigned any material rights under any
material contract or claims, except in the ordinary course of business and
consistent with past practice;

               (o) except as expressly required by this Agreement, entered into
any material commitment or transaction (including any capital expenditure or
purchase, sale or lease of assets or real estate) other than as disclosed in the
operating plan and budget provided to certain of the Investors on July 29, 2002;

               (p) revalued in any material respect any of its assets, including
writing down the value of inventory or writing-off notes or accounts receivable,
other than in the ordinary course of business consistent with past practice or
as required by GAAP;

               (q) permitted any insurance policy naming it as a beneficiary or
a loss payable payee to be cancelled or terminated without notice to and the
prior consent of the Investors, except policies providing coverage for losses
not in excess of fifty thousand dollars ($50,000);

               (r) entered into any contract or transaction relating to the
purchase of assets other than in the ordinary course of business and consistent
with prior practices as set forth in the operating plan and budget provided to
certain of the Investors on July 29, 2002;

               (s) settled or compromised any pending or threatened suit, action
or claim that (i) relates to the transactions contemplated hereby, or (ii) the
settlement or compromise of which would involve more than twenty-five thousand
dollars ($25,000) or that would otherwise be material to the Company and its
Subsidiaries, taking the Company together with its Subsidiaries as a whole, or
that primarily relates to any material Intellectual Property matter;

               (t) adopted a plan of complete or partial liquidation,
dissolution, merger, consolidation, restructuring, recapitalization or other
reorganization of the Company or any of its Subsidiaries; or

               (u) agreed, whether in writing or otherwise, to take any action
described in this section.

        3.12 Litigation. Except as disclosed in the Company SEC Documents, there
is no action, suit, inquiry, proceeding or investigation by or before any
Governmental Entity or, to the knowledge of the Company and its Subsidiaries,
threatened against or involving the Company or any of its Subsidiaries, or which
questions or challenges the validity of this Agreement or any action taken or to
be taken by the Company or any of its Subsidiaries pursuant to this Agreement or
in connection with the Transactions. Neither the Company nor any of its
Subsidiaries is in default under or in violation of, nor to the knowledge of the
Company and its Subsidiaries is there any valid basis for any claim of default
under or violation of, any Company Agreement. Neither the Company nor any of its
Subsidiaries is subject to any judgment, order or decree that materially
restricts its business practices or its ability to acquire any property or
conduct its business in any area.

                                                                            -19-
<PAGE>

        3.13 Employee Benefit Plans.

               (a) Section 3.13 of the Company Disclosure Schedule lists each
Company Benefit Plan.

               (b) With respect to each Company Benefit Plan, Company has
delivered to the Investors a true, complete and correct copy of (i) such Company
Benefit Plan (of, if not written, a written summary of its material terms) and
the most recent summary plan description and summary of material modifications,
if any, related to such Company Benefit Plan, (ii) each trust agreement or other
funding arrangement, (iii) the most recent annual report (Form 5500) filed with
the IRS) (and, if the most recent annual report is a Form 5500R, the most recent
Form 5500C filed with respect to such Company Benefit Plan), (iv) the most
recent actuarial report or financial statement, if applicable, (v) the most
recent determination letter, if any, issued by the IRS and any pending request
for a determination letter, if any, and (vi) each registration statement, permit
application and prospectus. Neither the Company nor any of its Subsidiaries nor,
to the knowledge of the Company and its Subsidiaries, any other Person or
entity, has any express or implied commitment, whether legally enforceable or
not, to continue (for any period), modify, change or terminate any Company
Benefit Plan, other than with respect to a modification, change or termination
required by ERISA or the Internal Revenue Code.

               (c) Each Company Benefit Plan has been administered in all
material respects in accordance with its terms and all applicable laws,
including ERISA and the Internal Revenue Code (including the prohibited
transaction rules thereunder), and contributions required to be made under the
terms of any of the Company Benefit Plans as of the date of this Agreement have
been timely made or, if not yet due, have been properly reflected on the Balance
Sheet. No suit, administrative proceeding, action or other adverse proceeding or
claim is currently pending or, to the Company's knowledge, threatened in writing
against or with respect to any such Company Benefit Plan (other than routine
benefits claims) and there is no pending audit or inquiry by the Internal
Revenue Service or United States Department of Labor with respect to any Company
Benefit Plan. To the knowledge of Company or any of its Subsidiaries, there
exists no condition or set of circumstances that could subject the Company or
any of its Subsidiaries to any material liability (other than for routine
benefit liabilities) relating in any way to any Company Benefit Plan.

               (d) Each Company Benefit Plan can be amended, discontinued or
terminated at any time in accordance with its terms, without liability (other
than (A) liability for ordinary administrative expenses typically incurred in a
termination event or (B) liabilities for which sufficient assets are set aside
in a trust or insurance contract to satisfy such liability or which are
reflected on the Balance Sheet).

               (e) Each Company Benefit Plan and its related trust that is
intended to qualify under Section 401(a) or 4975(e)(7) and Section 501(a),
respectively, of the Internal Revenue Code has received a favorable
determination letter from the IRS as to such qualified status or has been
established under a standardized prototype plan for which an Internal Revenue
Service opinion letter has been obtained by the plan sponsor and was valid when
issued as to the adopting employer.

                                                                            -20-
<PAGE>

               (f) No Company Benefit Plan is a multiemployer pension plan (as
defined in Section 3(37) of ERISA) or other pension plan subject to Title IV of
ERISA or the minimum funding rules of ERISA or the Internal Revenue Code and no
Company ERISA Affiliate has sponsored or contributed to or been required to
contribute to any such pension plan.

               (g) With respect to each Benefit Plan required to be set forth in
the Company Disclosure Schedule that is subject to Title IV of ERISA or the
minimum funding rules of ERISA or the Internal Revenue Code, (i) no reportable
event (within the meaning of Section 4043 of ERISA, other than an event that is
not required to be reported before or within thirty (30) days of such event) has
occurred or is expected to occur, (ii) there was not an accumulated funding
deficiency (within the meaning of Section 302 of ERISA or Section 412 of the
Internal Revenue Code), whether or not waived, as of the most recently ended
plan year of such Benefit Plan; and (iii) there is no "unfunded benefit
liability" (within the meaning of Section 4001(a)(18) of ERISA). No material
liability under Title IV of ERISA has been incurred by the Company or any other
Company ERISA Affiliate that has not been satisfied in full, and no condition
exists that presents a material risk to Company or any of its Subsidiaries of
incurring or being subject (whether primarily, jointly or secondarily) to a
material liability thereunder. None of the assets of the Company or any of its
Subsidiaries is, or may reasonably be expected to become, the subject of any
lien arising under ERISA or Section 412(n) of the Internal Revenue Code.

               (h) Except as required by law, no Company Benefit Plan provides
any of the following retiree or post-employment benefits to any person: medical,
disability or life insurance benefits. To the knowledge of the Company and its
Subsidiaries, the Company and each of its Subsidiaries are in compliance with
(i) the requirements of the applicable health care continuation and notice
provisions of the Consolidated Omnibus Budget Reconciliation Act of 1985, as
amended, and (ii) the applicable requirements of the Health Insurance
Portability and Accountability Act of 1996, as amended.

               (i) The Company has delivered to the Investors true, complete and
correct copies of (i) all employment agreements with officers and all consulting
agreements of the Company and each of its Subsidiaries providing for annual
compensation in excess of one hundred thousand dollars ($100,000), (ii) all
severance plans, agreements, programs and policies of the Company and each of
its Subsidiaries with or relating to their respective employees, directors or
consultants, and (iii) all plans, programs, agreements and other arrangements of
the Company and each of its Subsidiaries with or relating to their respective
employees, directors or consultants which contain "change of control"
provisions. The consummation of the Transactions will not, alone or in
conjunction with any other possible event (including termination of employment),
(i) entitle any current or former employee or other service provider of the
Company or any of its Subsidiaries to severance benefits or any other payment,
compensation or benefit (including forgiveness of indebtedness), except as
expressly provided by this Agreement, or (ii) accelerate the time of payment or
vesting, or increase the amount of compensation or benefit due any such employee
or service provider, alone or in conjunction with any other possible event
(including termination of employment).

                                                                            -21-
<PAGE>

               (j) The execution of, and performance of the transactions
contemplated by, this Agreement will not (either along with or upon the
occurrence of any additional or subsequent events) constitute an event under any
Company Benefit Plan or agreement that will or may reasonably be expected to
result in any payment (whether severance pay or otherwise), acceleration,
vesting or increase in benefits with respect to any employee, former employee or
director of the Company, or its Subsidiaries, whether or not any such payment
would be an "excess parachute payment" (within the meaning of Section 280G of
the Internal Revenue Code).

        3.14 Tax Matters.

               (a) The Company and each of its Subsidiaries have duly filed all
Tax Returns that are required to be filed, and have duly paid or caused to be
duly paid in full all Taxes reflected on such Tax Returns. All such Tax Returns
are correct and complete in all material respects and accurately reflect all
liability for Taxes for the periods covered thereby. All material unpaid Taxes
owed by the Company and all Company Subsidiaries relating to periods or portions
of periods through the Balance Sheet Date (whether or not shown on any Tax
Return) are reflected on the Financial Statements. Since the Balance Sheet Date,
the Company and the Company Subsidiaries have not incurred any liability for any
Taxes other than in the ordinary course of business. Neither the Company nor any
of its Subsidiaries has received written notice of any claim made by an
authority in a jurisdiction where the Company or the Company Subsidiary, as the
case may be, does not file Tax Returns, that the Company or the Company
Subsidiary is or may be subject to taxation by that jurisdiction.

               (b) The federal income Tax Returns of the Company and each of the
Company Subsidiaries have never been audited by the Internal Revenue Service (or
the applicable statutes of limitation for the assessment of federal income Taxes
for such periods have expired) for all periods through and including December
31, 2000, and the Company has never paid a material amount of Taxes in respect
of an Internal Revenue Service audit. Neither the Company nor any of its
Subsidiaries has waived any statute of limitations in any jurisdiction in
respect of Taxes or Tax Returns or agreed to any extension of time with respect
to a Tax assessment or deficiency.

               (c) No federal, state, local or foreign audit, examination or
other administrative proceeding is pending or, to the knowledge of the Company
and its Subsidiaries, threatened in writing with regard to any Taxes or Tax
Returns of the Company or of any of its Subsidiaries. There is no dispute or
claim concerning any Tax liability of the Company or any of its Subsidiaries
either claimed or raised by any taxing authority in writing.

               (d) Neither the Company nor any of its Subsidiaries is a party to
any agreement, plan, contract or arrangement that could result, separately or in
the aggregate, in a payment of any "excess parachute payments" within the
meaning of Section 280G of the Internal Revenue Code.

               (e) Neither the Company nor any of its Subsidiaries has filed a
consent pursuant to Section 341(f) of the Internal Revenue Code (or any
predecessor provision) concerning collapsible corporations, or agreed to have
Section 341(f)(2) of the Internal Revenue Code apply to any

                                                                            -22-
<PAGE>

disposition of a "subsection (f) asset" (as such term is defined in Section
341(f)(4) of the Internal Revenue Code) owned by the Company or any of its
Subsidiaries.

               (f) The Company has at no time been a "United States real
property holding corporation" within the meaning of Section 897(c) of the
Internal Revenue Code.

               (g) Neither the Company nor any of its Subsidiaries is a party to
any material Tax sharing, Tax indemnity or other agreement or arrangement with
any entity not included in the Company's consolidated financial statements most
recently filed by the Company with the SEC.

               (h) Neither the Company nor any of its Subsidiaries has been a
member of any affiliated group within the meaning of Section 1504(a) of the
Internal Revenue Code, or any similar affiliated or consolidated group for Tax
purposes under state, local or foreign law (other than a group the common parent
of which is the Company), or has any liability for Taxes of any Person (other
than the Company and the Company Subsidiaries) under Treasury Regulation Section
1.1502-6 (or any similar provision of state, local or foreign law), as a
transferee or successor, by contract or otherwise.

        3.15 Title to Properties; Encumbrances. Each of the Company and each of
its Subsidiaries has good, valid and marketable title to all the material
properties and assets which it purports to own (real, personal and mixed,
tangible and intangible) and which are reflected in the Balance Sheet, and all
the material properties and assets purchased by the Company and its Subsidiaries
since the date of the Balance Sheet, in each case free and clear of all
mortgages, title defects or objections, liens, claims, charges, security
interests or other encumbrances of any nature whatsoever including, leases,
chattel mortgages, conditional sales contracts, collateral security arrangements
and other title or interest retention arrangements, except, with respect to all
such properties and assets: (a) liens shown on the Balance Sheet as securing
specified liabilities or obligations, with respect to which no default exists;
(b) minor imperfections of title, if any, none of which are substantial in
amount, materially detract from the value or impair the use of the property
subject thereto, or impair the operations of the Company or any of its
Subsidiaries and which have arisen only in the ordinary course of business and
consistent with past practice since the date of the Balance Sheet; and (c) liens
for current Taxes not yet due. The rights, properties and other assets presently
owned, leased or licensed by the Company and its Subsidiaries and described
elsewhere in this Agreement include all rights, properties and other assets
necessary to permit the Company and its Subsidiaries to conduct their businesses
in all material respects in the same manner as their businesses have been
conducted prior to the date hereof.

        3.16 Leases. Section 3.16 of the Company Disclosure Schedule contains an
accurate and complete description of the terms of all material leases pursuant
to which the Company or any of its Subsidiaries leases real or personal
property. All such leases are valid, binding and enforceable in accordance with
their terms, and are in full force and effect. To the Company's knowledge, there
is no existing material default by the Company or any of its Subsidiaries
thereunder, and no event has occurred which (whether with or without notice,
lapse of time or the happening or occurrence of any other event) would
constitute a material default thereunder.

                                                                            -23-

<PAGE>

        3.17 Environmental Laws. (a) The Company and each of its Subsidiaries
are in compliance in all material respects with all Environmental Laws,
including compliance with any permits or other governmental authorizations or
the terms and conditions thereof, (b) neither the Company nor any of its
Subsidiaries has received any communication or notice, whether from a
governmental authority or otherwise, alleging any material violation of or
material noncompliance with any Environmental Laws by the Company, any of its
Subsidiaries, and there is no pending or, to the knowledge of the Company and
its Subsidiaries, threatened material Environmental Claim against the Company or
any of its Subsidiaries; and (c) to the knowledge of the Company and its
Subsidiaries, there is no past or present fact or circumstance that could
reasonably be expected to result in any Environmental Claim against the Company
or any of its Subsidiaries or any environmental liability of the Company or any
of its Subsidiaries which could reasonably be expected to result in a Company
Material Adverse Effect. The Company has delivered to the Investors all Phase I
and Phase II Environmental Site Assessment reports in the possession of the
Company.

        3.18 Intellectual Property.

               (a) Section 3.18(a) of the Company Disclosure Schedule contains a
true and complete list of all of the Company Patents, registered Company
Copyrights, Company Trademarks, and the Company's Internet domain names and the
Company's Internet domain name applications.

               (b) Trademarks. To the Company's knowledge, all Company Trademark
registrations are currently in compliance in all material respects with all
legal requirements (including the timely post-registration filing of affidavits
of use and incontestability and renewal applications) other than any requirement
that, if not satisfied, would not result in a cancellation of any such
registration or otherwise materially affect the priority and enforceability of
the Company Trademark in question. To the Company's knowledge, no registered
Company Trademark is now involved in any opposition or cancellation proceeding
in the United States Patent and Trademark Office. To the knowledge of the
Company and its Subsidiaries, no such action has been threatened in writing
within the one (1)-year period prior to the date of this Agreement. To the
knowledge of the Company and its Subsidiaries, there has been no prior use of
any material Company Trademark by any third party that confers upon said third
party superior priority to register such Company Trademark.

               (c) Patents. To the Company's knowledge, all issued Company
Patents are currently in compliance with legal requirements (including payment
of filing, examination, and maintenance fees and proofs of working or use) other
than any requirement that, if not satisfied, would not result in a revocation or
otherwise materially affect the enforceability of the Company Patent in
question. To the Company's knowledge, no Company Patent is now involved in any
interference, reissue, reexamination or opposing proceeding in the United States
Patent and Trademark Office. To the knowledge of the Company and its
Subsidiaries, no such action has been threatened within the one (1)-year period
prior to the date of this Agreement. To the knowledge of

                                                                            -24-
<PAGE>

the Company and its Subsidiaries, there is no issued patent or patent
application of any Person that invalidates any claim of any issued Company
Patent.

               (d) Trade Secrets. The Company and each of its Subsidiaries have
taken reasonable steps in accordance with normal industry practice to protect
their respective rights in Company's confidential information and the Company
Trade Secrets, the secrecy of which is material to the business of the Company
or its Subsidiaries. Without limiting the generality of the foregoing, the
Company and each of its Subsidiaries generally enforces a policy of requiring
each relevant employee, consultant and contractor to execute agreements that
contain provisions designed to prevent unauthorized disclosure of the Company's
confidential information and Company Trade Secrets. With respect to employees,
such agreements assign to the Company or such Subsidiary, as the case may be,
all rights to any Intellectual Property relating to the Company's or such
Subsidiary's business that is developed by the employee in the course of his or
her activities as an employee of the Company or any of its Subsidiaries. With
respect to contractors and consultants, the agreements either assign all
Intellectual Property Rights developed pursuant to the agreement, which the
Company determined at the time was material to its business or license such
rights on agreed-upon terms. Except under confidentiality obligations, to the
knowledge of the Company and its Subsidiaries, there has been no disclosure by
the Company or any of its Subsidiaries of material confidential information or
material Trade Secrets of Company.

               (e) License Agreements. Section 3.18(e)(i) of the Company
Disclosure Schedule sets forth a complete and accurate list of all license
agreements granting to the Company or any of its Subsidiaries any material right
to incorporate any Intellectual Property into any commercial product of the
Company other than software commercially available on reasonable terms to any
person for a license fee of no more than twenty-five thousand dollars ($25,000)
(collectively, the "Inbound License Agreements"). Section 3.18(e)(ii) of the
Company Disclosure Schedule sets forth a complete and accurate list of all
license agreements under which the Company or any of its Subsidiaries licenses
or grants a third party material rights to incorporate any rights under any
Company Intellectual Property into any commercial product of such third party
(collectively, the "Outbound License Agreements"). To the knowledge of the
Company and its Subsidiaries, there is no material outstanding or, to the
knowledge of the Company and its Subsidiaries, threatened dispute or
disagreement with respect to any Inbound License Agreement or any Outbound
License Agreement.

               (f) Ownership; Sufficiency of IP Assets. The Company or one of
its Subsidiaries owns or possesses adequate licenses or other rights to use,
free and clear of Liens, orders and arbitration awards, all of its material
Intellectual Property used in its business. The Intellectual Property identified
in Section 3.18(a) of the Company Disclosure Schedule, together with the
Company's and its Subsidiaries' Trade Secrets, unregistered copyrights, and the
Company's and such Subsidiaries' rights under the licenses granted to the
Company or any of its Subsidiaries under the Inbound License Agreements and any
other Intellectual Property owned by the Company or its Subsidiaries or to which
the Company or its Subsidiaries has a license or other right to use, constitute
all the material Intellectual Property rights used in the operation of the
Company's and its Subsidiaries' businesses as they are currently conducted and,
to the Company's knowledge, are all

                                                                            -25-
<PAGE>

the Intellectual Property rights necessary to operate such businesses after the
Closing in substantially the same manner as such businesses have been operated
by the Company and its Subsidiaries prior thereto.

               (g) Protection of IP. The Company has taken reasonable steps to
protect the material Intellectual Property of the Company and its Subsidiaries.

               (h) No Infringement by the Company. To the knowledge of the
Company and its Subsidiaries, none of the products manufactured, marketed, used,
sold or licensed by the Company or its Subsidiaries, and none of the
Intellectual Property used by the Company or its Subsidiaries in the conduct of
the Company's or its Subsidiaries' businesses as currently conducted, infringes
upon, violates or constitutes the unauthorized use of any valid and enforceable
rights owned or controlled by any third party.

               (i) No Pending or Threatened Infringement Claims. No litigation
to which the Company is a party is now pending and, to the knowledge of the
Company and its Subsidiaries, no notice or other claim in writing has been
received by the Company or any of its Subsidiaries within the one (1) year prior
to the date of this Agreement, (i) alleging that the Company or any of its
Subsidiaries has engaged in any activity or conduct that infringes upon,
violates or constitutes the unauthorized use of the Intellectual Property rights
of any third party or (ii) challenging the ownership, use, validity or
enforceability of any Intellectual Property owned by or exclusively licensed to
or by the Company. To the knowledge of the Company and its Subsidiaries, no
Intellectual Property (y) that is owned by the Company or any of its
Subsidiaries is subject to any outstanding order, judgment, decree, stipulation
or agreement materially restricting the use, sale, transfer, assignment or
licensing thereof by the Company or any such Subsidiary, except as may be
specifically provided in any such Outbound License Agreement or other Licenses,
or (z) that is the subject of an Inbound License Agreement is, to the knowledge
of the Company and its Subsidiaries, subject to any outstanding judgment,
decree, stipulation or agreement materially restricting the use, sale, transfer,
assignment or licensing thereof by the Company or any of its Subsidiaries,
except as provided in the Inbound License Agreements or other Licenses.

               (j) No Infringement by Third Parties. To the knowledge of the
Company and its Subsidiaries, no third party is misappropriating, infringing,
diluting or violating any Intellectual Property owned by the Company or any of
its Subsidiaries, and no such claims have been brought against any third party
by the Company or any of its Subsidiaries.

               (k) Assignment; Change of Control. The execution, delivery and
performance by the Company of this Agreement, and the consummation of the
transactions contemplated hereby, will not result in the loss or impairment of,
or give rise to any right of any third party to terminate or materially alter,
any of the Company's or any of its Subsidiaries' material rights to own any of
its Intellectual Property or their respective material rights under any Inbound
License Agreement or Outbound License Agreement, nor require the consent of any
Governmental Authority or third party in respect of any such Intellectual
Property.

                                                                            -26-
<PAGE>

        3.19 Employment Matters.

               (a) The Company and each of its Subsidiaries are in compliance in
all material respects with all currently applicable laws and regulations
respecting employment, discrimination in employment, terms and conditions of
employment, wages, hours and occupational safety and health and employment
practices, and is not engaged in any unfair labor practice. The Company and each
of its Subsidiaries have withheld all amounts required by law or by agreement to
be withheld from the wages, salaries, and other payments to employees, and
neither the Company nor any of its Subsidiaries is liable for any arrears of
wages or any Taxes or any penalty for failure to comply with any of the
foregoing. Neither the Company nor any of its Subsidiaries is liable for any
payment to any trust or other fund or to any governmental or administrative
authority, with respect to unemployment compensation benefits, social security
or other benefits or obligations for employees (other than routine payments to
be made in the normal course of business and consistent with past practice).
There is no pending claim against the Company or any of its Subsidiaries under
(i) any workers compensation plan or policy or (ii) for long-term disability
benefits. There is no controversy pending or, to the knowledge of the Company
and its Subsidiaries, threatened, between the Company or any of its
Subsidiaries, on the one hand, and any of their respective employees, on the
other hand, which controversies have resulted, or could reasonably be expected
to result, in an action, suit, proceeding, claim, arbitration or investigation
before any agency, court or tribunal, foreign or domestic. Neither the Company
nor any of its Subsidiaries is a party to any collective bargaining agreement or
other labor union contract. To the knowledge of the Company and its
Subsidiaries, no employees of the Company or any of its Subsidiaries are in
violation of any term of any material employment contract, patent disclosure
agreement, noncompetition agreement, or any restrictive covenant to a former
employer relating to the right of any such employee to be employed by the
Company or a Subsidiary of the Company because of the nature of the business
conducted or presently proposed to be conducted by the Company or any of its
Subsidiaries or to the use of trade secrets or proprietary information of
others. No employee of the Company or any of its Subsidiaries have given written
notice to the Company or any of its Subsidiaries, and neither the Company nor
any of its Subsidiaries is otherwise aware, that any such employee intends to
terminate his or her employment with the Company or any of its Subsidiaries.

               (b) Section 3.19(b) of the Company Disclosure Schedule lists the
name, place of employment, the current annual salary rates, bonuses, deferred or
contingent compensation, pension, accrued vacation, "golden parachute" and other
like benefits paid or payable (in cash or otherwise), the date of employment and
a description of position and job function of each current salaried employee,
officer, director, consultant or agent of the Company or any of its Subsidiaries
whose annual compensation exceeded (or, in 2002, is expected to exceed) one
hundred thousand dollars ($100,000).

               (c) All officers, employees and consultants of the Company and
each of its Subsidiaries have signed proprietary rights and confidentiality
agreements in substantially the form set forth in Section 3.19(c) of the Company
Disclosure Schedule.

                                                                            -27-
<PAGE>

        3.20 Compliance with Laws. The Company and each of its Subsidiaries are
in compliance in all material respects with, and have not violated in any
material respect any applicable material law, rule or regulation of any United
States federal, state, local, or foreign Governmental Entity applicable to the
Company or any of its Subsidiaries, and no notice, charge, claim, action or
assertion has been received by the Company or any of its Subsidiaries or has
been filed, commenced or, to the knowledge of the Company and its Subsidiaries,
threatened against the Company or any of its Subsidiaries alleging any such
violation. All licenses, permits and approvals required under such laws, rules
and regulations are in full force and effect except where the failure to be in
full force and effect would not reasonably be expected to result in a Company
Material Adverse Effect.

        3.21 Contracts and Commitments.

               (a) Except for agreements, contracts and commitments filed as
exhibits to the Company SEC Documents, neither the Company nor any of its
Subsidiaries has any agreements, contracts and commitments which are material to
the Company and its Subsidiaries, taking the Company together with its
Subsidiaries as a whole.

               (b) No purchase contract or commitment of the Company or any of
its Subsidiaries continues for a period of more than twelve (12) months or is in
excess of the normal, ordinary and usual requirements of business.

               (c) Neither the Company nor any of its Subsidiaries has any
outstanding contracts with any officer, employee, agent, consultant, advisor,
salesperson, sales representative, distributor or dealer that is not cancelable
by it on notice of not longer than thirty (30) days and without liability,
penalty or premium or any agreement or arrangement providing for the payment of
any material bonus or commission based on sales or earnings.

               (d) Neither the Company nor any of its Subsidiaries has any
employment agreement, or any other similar agreement that contains any severance
or termination pay liabilities or obligations.

               (e) Neither the Company nor any of its Subsidiaries is in
material default, nor is there any known basis for any valid claim of material
default, under any agreement, contract or commitment which is material to the
Company and its Subsidiaries, taking the Company together with its Subsidiaries
as a whole.

               (f) Neither the Company nor any of its Subsidiaries is restricted
by agreement from carrying on its business anywhere in the world.

               (g) Neither the Company nor any of its Subsidiaries has any debt
obligation for borrowed money, including any guarantee of or agreement to
acquire any such debt obligation of others.

                                                                            -28-
<PAGE>

               (h) Neither the Company nor any of its Subsidiaries has any
outstanding loan to any Person other than to the Company or a wholly-owned
Subsidiary of the Company.

               (i) Neither the Company nor any of its Subsidiaries has any power
of attorney outstanding or any obligation or liability (whether absolute,
accrued, contingent or otherwise) as guarantor, surety, co-signer, endorser,
co-maker, indemnitor or otherwise in respect of the obligation of any Person,
corporation, partnership, joint venture, association, organization or other
entity.

        3.22 Regulatory Compliance.

               (a) The Company and its Subsidiaries, and to the Company's
knowledge the Company's agents are in material compliance with all statutes,
rules and regulations of any Regulatory Authority with respect to the
evaluation, testing, manufacturing, distributing and marketing of each of their
products, in whatever stage of development, to the extent that the same are
applicable to the Company's and its Subsidiary's business as it is currently
conducted and proposed to be conducted in applications heretofore filed with
Regulatory Authorities, including but not limited to those relating to
investigational use, premarket clearance, current "Good Manufacturing
Practices", current "Good Laboratory Practices", current "Good Clinical
Practices" labeling, advertising, record keeping, reporting of adverse events,
filing of reports and security.

               (b) Section 3.22(b) of the Company Disclosure Schedule sets forth
a true, complete and accurate list of the products that are currently being,
developed, tested, manufactured, marketed, distributed, sold or licensed in or
out by the Company or its Subsidiary as of the date of this Agreement.

               (c) Section 3.22(c) of the Company Disclosure Schedule sets forth
a true, complete and accurate list of each of the Company's and its Subsidiary's
pending and approved New Drug Applications ("NDAs"), Investigational New Drug
Applications ("INDs") and similar state and foreign regulatory filings as of the
date of this Agreement. True and complete copies of such NDAs, INDs and similar
regulatory filings, including all supplements, amendments, and annual reports,
have heretofore been made available to the Investors. True and complete copies
of all correspondence from the FDA, and similar state and foreign Regulatory
Authorities, and the Company's and its Subsidiary's responses have heretofore
been made available to the Investors. As to each drug for which such an
application has been approved or become effective, Company and its Subsidiaries
are in substantial compliance with 21 U.S.C. Section 355 or 21 C.F.R. Parts 312,
and 314 et seq., respectively, and similar state and foreign laws and
regulations and all terms and conditions of such applications. As to each such
drug, the Company and its Subsidiaries, and their respective officers,
employees, agents and representatives have included in the application for such
drug, where required, the certification described in 21 U.S.C. Section
335a(k)(1) and any similar state and foreign law and regulation and the list
described in 21 U.S.C. Section 335a(k)(2) and any similar state and foreign law
and regulation, and such certification and such list was in each case true and
accurate when made and remained true, complete and accurate thereafter. In
addition, the Company and its Subsidiaries are in substantial compliance with
all applicable registration and listing requirements set forth in 21 U.S.C.
Section 360 and 21 C.F.R. Part 207 and all similar state and foreign laws and
regulations.

                                                                            -29-
<PAGE>

               (d) Section 3.22(d)(i) of the Company Disclosure Schedule sets
forth a true, complete and accurate list of (A) Form 483s, (B) Notices of
Adverse Findings and (C) warning letters or other correspondence from the FDA
and other Regulatory Authorities in which the FDA or any such authority asserted
that the operations of the Company or its Subsidiary may not be in compliance
with applicable laws, regulations, orders, judgments or decrees, in each case
received by the Company or its Subsidiary from the FDA or any such authority and
the response of the Company and/or its Subsidiary to the FDA and/or any such
authority to such notices from the FDA and/or any such authority. True and
complete copies of such Form 483s, Notices of Adverse Findings, warning letters
and other correspondence and the Company's and/or its Subsidiary's responses
have heretofore been made available to the Investors. Except as set forth in
Section 3.22(d)(ii) of the Company Disclosure Schedule, all operations of the
Company and its Subsidiaries have been and are being conducted in substantial
compliance with all FDA requirements as summarized in Section 3.22(a) above.

               (e) The Company has provided to the Investors all Adverse
Reaction Reports filed by the Company or any of its Subsidiaries with all
Regulatory Authorities with respect to its Phase II and Phase III studies.
Section 3.22(e) of the Company Disclosure Schedule sets forth all such Adverse
Reaction Reports filed with Regulatory Authorities.

               (f) Neither the Company nor any of its Subsidiaries, nor any
officer, employee or agent of the Company or any of its Subsidiaries has made an
untrue statement of a material fact or fraudulent statement to the FDA or any
other Regulatory Authority or other Governmental Entity, failed to disclose a
material fact required to be disclosed to the FDA or any other Regulatory
Authority or other Governmental Entity, or committed an act, made a statement,
or failed to make a statement that, at the time such disclosure was made, could
reasonably be expected to provide a basis for the FDA or any other Regulatory
Authority or other Governmental Entity to invoke its policy respecting Fraud,
Untrue Statements of Material Facts, Bribery, and Illegal Gratuities, set forth
in 56 Fed. Reg. 46191 (September 10, 1991) or any similar policy. Neither the
Company nor any of its Subsidiaries, nor any officer, employee or agent of the
Company or any of its Subsidiaries, has been convicted of any crime or engaged
in any conduct for which debarment is mandated by 21 U.S.C. Section 335a(a) or
any similar state or foreign law or regulation or for which debarment is
authorized by 21 U.S.C. Section 335a(b) or any similar state or foreign law or
regulation.

               (g) Except as disclosed in the Company's SEC Filings, neither the
Company nor any of its Subsidiaries has received any written notice that the FDA
or any other Regulatory Authority or other Governmental Entity has commenced, or
threatened in writing to initiate, any action to withdraw its approval or
request the recall of any product of the Company or any of its Subsidiaries, or
commenced, or overtly threatened to initiate, any action to enjoin production at
any facility of the Company or any of its Subsidiaries.

               (h) The Company and its Subsidiaries are, and have at all times
been, in substantial compliance with the Medicare Anti-Kickback Statute, 42
U.S.C. Section 1320a-7b(b), and

                                                                            -30-
<PAGE>

implementing regulations codified at 42 C.F.R. Section 1001 and with all similar
state and foreign laws and regulations.

        3.23 Studies. The clinical, preclinical, safety and other studies and
tests conducted by or on behalf of or sponsored by the Company or any of its
Subsidiaries or in which the Company or any of its Subsidiaries or the Company's
or its Subsidiary's products or product candidates under development have
participated, were and, if still pending, are being conducted in material
compliance with standard medical and scientific research procedures. The Company
and its Subsidiaries have operated within, and currently are in material
compliance with, all applicable rules, regulations and policies of the FDA and
other Regulatory Authorities. Neither the Company nor any of its Subsidiaries
has received any notices or other correspondence from the FDA, other Regulatory
Authorities, or any other Governmental Entity requiring the termination,
suspension or modification of any clinical, pre-clinical, safety or other
studies or tests.

        3.24 Rights Agreement; Delaware 203 Approval. The Company has taken all
action which may be necessary under the Rights Agreement, so that the execution
of this Agreement and any amendments thereto by the parties hereto and the
consummation of each of the Transactions shall not cause (i) any Investor or
group of Investors to become an Acquiring Person (as defined in the Rights
Agreement) or (ii) a Distribution Date, a Share Acquisition Date or a Trigger
Event (as such terms are defined in the Rights Agreement) to occur. Prior to the
date of this Agreement, the Company's board of directors, at a meeting duly
called and held, has (a) determined that each of the Bridge Loan Agreement, the
Agreement, the Warrants, and the Transactions are fair to, advisable and in the
best interests of the Company and the stockholders of the Company, (b) approved
the Transactions, and (c) resolved to recommend that the stockholders of the
Company approve the issuance of Common Shares and Warrants pursuant to this
Agreement , and shares of Common Stock upon conversion of the Bridge Notes and
exercise of the Bridge Warrants pursuant to the Bridge Loan Agreement. The
action taken by the Company's board of directors constitutes approval of the
Transactions by the Company's board of directors under the provisions of Section
203 of the DGCL such that Section 203 of the DGCL does not apply to this
Agreement or the Transactions, and such approval has not been amended, rescinded
or modified. No other state takeover, antitakeover, moratorium, fair price,
interested stockholder, business combination or similar statute or rule is
applicable to the Transactions. If any state takeover statute other than Section
203 of the DGCL becomes or is deemed to become applicable to this Agreement or
the Transactions, the Company shall (and shall cause each of its applicable
Subsidiaries to) take all reasonable action necessary to render such statute
inapplicable to all of the foregoing. On or prior to the date of this Agreement,
(i) each of the Resigning Directors has submitted written resignations from the
boards of directors of the Company and its Subsidiaries and all committees
thereof, effective as of, and subject only to the occurrence of, the Closing,
and (ii) the Company's board of directors has appointed to the Company's board
of directors the Sprout Designees and the IGC Designee, effective immediately
following, and subject only to the occurrence of, the Closing and the
effectiveness of the resignations of their respective predecessors (the "Board
Consent"), a copy of each such resignation and the Board Consent having been
delivered to the Investors and their counsel. The Chief Executive Officer of the
Company and the Sanderling Designee are members of the Company's Board of
Directors.

                                                                            -31-
<PAGE>

        3.25 Absence of Questionable Payments. Neither the Company nor any of
its Subsidiaries nor to the Company's knowledge, any director, officer, agent,
employee or other Person acting on behalf of the Company or any of its
Subsidiaries, has used any corporate or other funds for any unlawful
contribution, payment, gift, or entertainment, or made any unlawful expenditure
relating to political activity to government officials or others or established
or maintained any unlawful or unrecorded funds in violation of Section 30A of
the Exchange Act. Neither the Company nor any of its Subsidiaries nor, to the
Company's knowledge, any current director, officer, agent, employee or other
Person acting on behalf of the Company or any of its Subsidiaries, has accepted
or received any unlawful contribution, payment, gift or expenditure. The Company
and each of its Subsidiaries which is required to file reports pursuant to
Section 12 or 15(d) of the Exchange Act is in compliance with the provisions of
Section 13(b) of the Exchange Act.

        3.26 Insider Interests. To the Company's knowledge, no executive officer
or director of the Company or any of its Subsidiaries has any material interest
in any material property, real or personal, tangible or intangible, including
any invention, patent, trademark or trade name, used in or pertaining to the
business of the Company or any of its Subsidiaries.

        3.27 Brokers or Finders. No agent, broker, investment banker, financial
advisor or other firm or Person is or will be entitled to any brokers' or
finder's fee or any other commission or similar fee in connection with any of
the Transactions except for amounts paid or payable to the Financial Advisor.
All terms of the Company's arrangements with the Financial Advisor have been
disclosed to the Investors in the engagement letters by and between the Company
and the Financial Advisor dated January 16, 2002 (as amended as of May 21, 2002)
and July 8, 2002, and the Settlement Agreement and Mutual Release dated
September 18, 2002.

                                    Section 4

           Representations, Warranties and Covenants of the Investors

        Each Investor, severally and not jointly, hereby represents and warrants
to the Company as follows:

        4.1 Authorization. (i) Such Investor has all requisite legal and
corporate or other power and capacity and has taken all requisite corporate or
other action to execute and deliver this Agreement, to purchase the Common
Shares and Warrant to be purchased by it and to carry out and perform all of its
obligations under this Agreement; and (ii) this Agreement constitutes the legal,
valid and binding obligation of such Investor, enforceable in accordance with
its terms, except (A) as limited by applicable bankruptcy, insolvency,
reorganization, or similar laws relating to or affecting the enforcement of
creditors' rights generally and (B) as limited by equitable principles
generally.

        4.2 Investment Experience. Such Investor is an "Accredited Investor" as
defined in Rule 501(A) under the Securities Act. Such Investor is aware of the
Company's business affairs and financial condition and has had access to due
diligence information, and the opportunity to ask

                                                                            -32-
<PAGE>

questions of, and receive answers from, representatives of the Company, in each
case concerning the finances, operations, and business of the Company, and has
acquired sufficient information about the Company to reach an informed and
knowledgeable decision to acquire the Common Shares and Warrant. Such Investor
has such sophistication, knowledge and experience in financial and business
matters so as to be capable of evaluating the merits and risks of investing in
the Company, and has the ability to bear the economic risks of investing in the
Company, including a complete loss of such investment.

        4.3 Investment Intent. Such Investor is purchasing the Common Shares and
the Warrant for its own account as principal, for investment purposes only, and
not with a present view to, or for, resale, distribution or fractionalization
thereof, in whole or in part, within the meaning of the Securities Act. Such
Investor understands that its acquisition of the Common Shares and the Warrant
has not been registered under the Securities Act or registered or qualified
under any state securities law in reliance on specific exemptions therefrom,
which exemptions may depend upon, among other things, the bona fide nature of
such Investor's investment intent as expressed herein. Such Investor will not,
directly or indirectly, offer, sell, pledge, transfer or otherwise dispose of
(or solicit any offers to buy, purchase or otherwise acquire or take a pledge
of) any of the Common Shares and the Warrant, except in compliance with the
terms of this Agreement and the registration requirements of the Securities Act,
and the rules and regulations promulgated thereunder, or an exemption
thereunder.

        4.4 Registration or Exemption Requirements. Such Investor further
acknowledges and understands that the Common Shares and the Warrant may not be
resold or otherwise transferred except in a transaction registered under the
Securities Act or unless an exemption from such registration is available. Such
Investor understands that the Warrant and the certificate(s) evidencing the
Common Shares will be imprinted with a legend that prohibits the transfer of
such securities unless (i) they are registered or such registration is not
required, and (ii) except as otherwise provided in Section 2.3(c), if the
transfer is pursuant to an exemption from registration under the Securities Act
and, if the Company shall so request in writing, an opinion of counsel
reasonably satisfactory to the Company is obtained to the effect that the
transaction is so exempt.

        4.5 No Legal, Tax or Investment Advice. Such Investor understands that
nothing in this Agreement or any other materials presented to such Investor in
connection with the purchase of the Common Shares or the Warrant constitutes
legal, tax or investment advice. Such Investor has consulted such legal, tax and
investment advisors as it, in its sole discretion, has deemed necessary or
appropriate in connection with its purchase of the Common Shares and the
Warrant.

                                    Section 5

                     Conditions to Closing of the Investors

        5.1 Conditions to Investors' Obligations at the Closing. The obligation
of each Investor to purchase the Common Shares and Warrant at the Closing under
this Agreement is subject to the

                                                                            -33-
<PAGE>

fulfillment on or prior to the Closing of the following conditions, any of which
may be waived, subject to Section 9.1 herein, in whole or in part by Consent of
the Investors:

               (a) Representations and Warranties True. The representations and
warranties made by the Company in Section 3 hereof shall be true and correct in
all respects as of the date hereof and at and as of the Closing with the same
force and effect as if they had been made on and as of said date (other than
representations and warranties made specifically with reference to a particular
date, which shall have been true and correct in all respects as of such date),
except in each case, or in the aggregate, where the failure to be true and
correct (disregarding any additional materiality "baskets" contained therein)
does not constitute a Company Material Adverse Effect.

               (b) Covenants. Each covenant, agreement and condition contained
in this Agreement to be performed by the Company on or prior to the Closing
shall have been performed or complied with in all material respects.

               (c) Compliance with Laws. The purchase of the Common Shares and
Warrant by each Investor hereunder shall be legally permitted by all laws and
regulations to which each Investor or the Company is subject.

               (d) Director Resignations. Such incumbent directors shall have
submitted written resignations from the board of directors and all committees
thereof, effective as of the Closing (the "Resigning Directors"), as are
necessary to (i) result in three vacancies on the Company's board of directors
immediately after the Closing and (ii) permit the following designees to the
Company's board of directors to take or hold office pursuant to Section 7.6: (i)
the Sprout Designees, one of which shall be a Class II Director; (ii) the
Sanderling Designee, as a Class III Director; and (iii) the IGC Designee, as a
Class I Director.

               (e) Board of Directors Designees. The Company's board of
directors (which shall have nine authorized directors as of the Closing) shall
have appointed, effective as of the Closing and subject to the resignations set
forth in Section 5.1(d) above, the Sprout Designees, the Sanderling Designee,
and the IGC Designee as members of the Company's board of directors and one
Sprout Designee and one IGC Designee to the compensation committee (which shall
have a total of three members), and one Sprout Designee, one IGC Designee, and
one Sanderling Designee to the nominating committee (which shall have a total of
three members), and each of such appointments shall be in full force and effect
and shall not have been amended, modified or rescinded, either directly or
indirectly.

               (f) Stockholder Approval. Stockholder Approval has been obtained.

               (g) Opinion of the Company's Counsel. Each Investor shall have
received from Wilson Sonsini Goodrich & Rosati, Professional Corporation,
counsel to the Company, an opinion letter addressed to each Investor in the form
attached as Exhibit C dated as of the Closing Date.

                                                                            -34-
<PAGE>

               (h) Amended Certificate of Incorporation. The Company shall have
filed the amendment and restatement of its amended and restated certificate of
incorporation in effect as of the date of this Agreement with the Secretary of
State of the State of Delaware in substantially the form of Exhibit D hereto
(the "Restated Certificate"); provided, however, the Company and each Investor
agree and acknowledge that the Restated Certificate will not include (and this
closing condition shall not apply to) the amendment providing for action by
written consent of the stockholders in lieu of a meeting if Stockholder Approval
is not obtained with respect to such provision.

               (i) AcSentient Amendment. AcSentient, Inc ("AcSentient") shall
have executed an amendment to the Asset Purchase and Sale Agreement, by and
between AcSentient and the Company, dated as of May 3, 2002 (the "AcSentient
Agreement"), which provides that the number of shares of Common Stock issuable
to AcSentient under the AcSentient Agreement shall be proportionately adjusted
for any stock split of the Company, including the Reserve Stock Split, and such
amendment shall be in full force and effect and no term thereof shall have been
amended, modified or waived, either directly or indirectly.

               (j) No Company Material Adverse Effect. No event has occurred
that has resulted in any Company Material Adverse Effect.

                                    Section 6

                      Conditions to Company's Obligations.

        6.1 Conditions to Company's Obligations at the Closing. The Company's
obligation to sell and issue the Common Shares and Warrants at the Closing is
subject to the fulfillment on or prior to the Closing of the following
conditions, any of which may be waived in whole or in part by the Company:

               (a) Representations and Warranties True. The representations and
warranties made by each Investor in Section 4 hereof shall be true and correct
in all material respects (disregarding any additional materiality "baskets"
contained therein) at and as of the Closing with the same force and effect as if
they had been made on and as of the same date (other than representations and
warranties made specifically with reference to a particular date, which shall
have been true and correct in all material respects as of such date).

               (b) Stockholder Approval. Stockholder Approval has been obtained.

               (c) Compliance with all Laws. At the Closing, the purchase of the
Common Shares and the Warrants by the Investors hereunder shall be legally
permitted by all laws and regulations to which the Investors or the Company are
subject.

                                                                            -35-
<PAGE>

                                    Section 7

                            Covenants of the Company

        7.1 Registration Rights. The Investors shall have the following
registration rights:

               (a)  Shelf Registration.

                      (i) Bridge Registration. The Company shall prepare and
file or cause to be prepared and filed with the SEC, as soon as practicable but
in any event no later than the earlier to occur of (A) fifteen (15) days after
the termination of this Agreement pursuant to Section 8 herein and (B) sixty
(60) days prior to the expiration of the Lock-Up Period, a Registration
Statement for an offering to be made on a delayed or continuous basis pursuant
to Rule 415 of the Securities Act registering the resale from time to time of
the Bridge Registrable Securities (the "Bridge Registration Statement") by
Investors holding such securities (the "Bridge Investors"). The Bridge
Registration Statement shall be on an appropriate form permitting registration
of such Bridge Registrable Securities for resale by such Bridge Investors in
accordance with the methods of distribution elected by the Bridge Investors and
set forth in the Bridge Registration Statement. The Company shall use its best
efforts to cause the Bridge Registration Statement to be declared effective
under the Securities Act no later than five (5) Business Days after receipt of
notice of "no review" by the SEC or ninety (90) days from the initial filing of
such Bridge Registration Statement in the event of SEC review, and to keep such
Bridge Registration Statement continuously effective under the Securities Act
until the earlier of (i) the date that is the later of (A) the second
anniversary of the date of the Bridge Loan Agreement and (B) the date that no
Bridge Investor, or any Affiliate of such Bridge Investor, is an Affiliate of
the Company, and (ii) such date as all securities registered on such Bridge
Registration Statement have been resold (the earlier to occur of (i) and (ii) is
the "Bridge Effectiveness Termination Date"); provided, however, that the
Company may suspend sales of Common Stock pursuant to such Bridge Registration
Statement for a period of not more than forty-five (45) days in the aggregate in
the event it determines in good faith that such Bridge Registration Statement
contains or may contain an untrue statement of material fact or omits or may
omit to state a material fact required to be stated therein or necessary to make
the statement therein not misleading; provided further and subject to the
provisions of this Section 7.1(a)(i), the Company shall promptly amend such
Bridge Registration Statement in order to correct any untrue statement and/or
ensure that such Bridge Registration Statement is not misleading. At the time
the Bridge Registration Statement is declared effective, each Bridge Investor
shall be named as a selling securityholder in the Registration Statement and the
related prospectus in such a manner as to permit such Bridge Investor to deliver
such prospectus to purchasers of registered securities in accordance with
applicable law.

                      (ii) PIPE Registration. The Company shall prepare and file
or cause to be prepared and filed with the SEC, as soon as practicable but in
any event no later than sixty (60) days prior to the expiration of the Lock-Up
Period, a Registration Statement for an offering to be made on a delayed or
continuous basis pursuant to Rule 415 of the Securities Act registering the
resale from

                                                                            -36-
<PAGE>

time to time by the Investors of the PIPE Registrable Securities (the "PIPE
Registration Statement"). The PIPE Registration Statement shall be on an
appropriate form permitting registration of such securities for resale by such
Investors in accordance with the methods of distribution elected by the
Investors and set forth in the PIPE Registration Statement. The Company shall
use its best efforts to cause the PIPE Registration Statement to be declared
effective under the Securities Act no later than five (5) Business Days after
receipt of notice of "no review" by the SEC or ninety (90) days from the initial
filing of such PIPE Registration Statement in the event of SEC review, and to
keep such PIPE Registration Statement continuously effective under the
Securities Act until the earlier of (i) the date that is the later of (A) the
second anniversary of the Closing Date and (B) the date that no Investor, or any
Affiliate of such Investor, is an Affiliate of the Company, and (ii) such date
as all securities registered on such PIPE Registration Statement have been
resold (the earlier to occur of (i) and (ii) is the "PIPE Effectiveness
Termination Date"); provided, however, that the Company may suspend sales of
Common Stock pursuant to such PIPE Registration Statement for a period of not
more than forty-five (45) days in the aggregate in the event it determines in
good faith that such PIPE Registration Statement contains or may contain an
untrue statement of material fact or omits or may omit to state a material fact
required to be stated therein or necessary to make the statement therein not
misleading; provided further and subject to the provisions of this Section
7.1(a)(ii), the Company shall promptly amend such PIPE Registration Statement in
order to correct any untrue statement and/or ensure that such PIPE Registration
Statement is not misleading. At the time the PIPE Registration Statement is
declared effective, each Investor shall be named as a selling securityholder in
the PIPE Registration Statement and the related prospectus in such a manner as
to permit such Investor to deliver such prospectus to purchasers of registered
securities in accordance with applicable law.

                      (iii) If a Registration Statement ceases to be effective
for any reason at any time prior to the applicable Effectiveness Termination
Date (other than because all securities registered thereunder have been resold
pursuant thereto), the Company shall use its best efforts to obtain the prompt
withdrawal of any order suspending the effectiveness thereof.

                      (iv) The Company shall supplement and amend a Registration
Statement if required by the rules, regulations or instructions applicable to
the registration form used by the Company for such Registration Statement, if
required by the Securities Act or, to the extent to which the Company does not
reasonably object, as reasonably requested by Consent of the Investors.

                      (v) Each Investor agrees that if such Investor wishes to
sell securities pursuant to a Registration Statement, it will do so only in
accordance with this Agreement.

               (b) Expenses of Registration. All Registration Expenses incurred
in connection with the registrations pursuant to Section 7.1(a) shall be borne
by the Company. "Registration Expenses" shall mean all expenses incurred by the
Company in complying with Sections 7.1(a) hereof including, without limitation,
all registration and filing fees, printing expenses, fees and disbursements of
one counsel for the Company and reasonable fees and disbursements of Investor
Counsel, blue sky fees and expenses, and the expense of any special audits
incident to or required by

                                                                            -37-
<PAGE>

any such registration (but excluding the compensation of regular employees of
the Company which shall be paid in any event by the Company and Selling Expenses
(as defined hereinafter). All Selling Expenses incurred in connection with any
registrations hereunder, shall be borne by the Investors. "Selling Expenses"
shall mean all underwriting discounts and selling commissions applicable to a
sale of the Registrable Securities.

        (c) Registration Procedures. In the case of a registration, and any
qualification or compliance effected by the Company pursuant to this Section
7.1, the Company will keep the Investors advised in writing as to the initiation
of such registration, qualification and compliance and as to the completion
thereof. At its expense the Company will:

                      (i) Prepare and file with the SEC such amendments and
supplements to such registration statement and the prospectus used in connection
with such registration statement as may be necessary to comply with the
provisions of the Securities Act with respect to the disposition of all
securities covered by such registration statement;

                      (ii) Furnish to the Investors such numbers of copies of a
prospectus, including a preliminary prospectus, in conformity with the
requirements of the Securities Act, and such other documents as they may
reasonably request in order to facilitate the disposition of Registrable
Securities owned by them;

                      (iii) Use its best efforts to register and qualify the
securities covered by such registration statement under such other securities or
Blue Sky laws of such jurisdictions as shall be reasonably requested by the
Investors, provided that the Company shall not be required in connection
therewith or as a condition thereto to qualify to do business or to file a
general consent to service of process in any such states or jurisdictions;

                      (iv) In the event of any underwritten public offering,
enter into and perform its obligations under an underwriting agreement, in usual
and customary form, with the managing underwriter of such offering. Each
Investor participating in such underwriting shall also enter into and perform
its obligations under such an agreement;

                      (v) Notify immediately each Investor holding Registrable
Securities covered by such registration statement at any time when a prospectus
relating thereto is required to be delivered under the Securities Act of the
happening of any event as a result of which the prospectus included in such
registration statement, as then in effect, includes an untrue statement of a
material fact or omits to state a material fact required to be stated therein or
necessary to make the statements therein not misleading in the light of the
circumstances then existing; provided, however, that the Company shall promptly
amend such Registration Statement in order to correct any untrue statement
and/or ensure that such Registration Statement is not misleading;

                      (vi) Cause all such Registrable Securities registered
hereunder to be listed or included on each securities exchange or automated
quotation system on which similar securities issued by the Company are then
listed or included;

                                                                            -38-
<PAGE>

                      (vii) Provide a transfer agent and registrar for all
Registrable Securities registered hereunder and a CUSIP number for all such
Registrable Securities, in each case not later than the effective date of such
registration; and

                      (viii) Use its best efforts to furnish, at the request of
any Investor requesting registration of Registrable Securities pursuant to this
Section 7.1, on the date that such Registrable Securities are delivered to the
underwriters for sale in connection with a registration pursuant to this Section
7.1, if such securities are being sold through underwriters, or, if such
securities are not being sold through underwriters, on the date that the
registration statement with respect to such securities becomes effective, (i) an
opinion, dated such date, of the counsel representing the Company for the
purposes of such registration, in form and substance as is customarily given in
an underwritten public offering (and reasonably acceptable to the counsel for
the Investors), addressed to the underwriters, if any, and to the Investors, and
(ii) a letter dated such date, from the independent certified public accountants
of the Company, in form and substance as is customarily given by independent
certified public accountants in an underwritten public offering (and reasonably
acceptable to the counsel for the Investors), addressed to the underwriters, to
the extent such letter is permitted under generally recognized accounting
practice.

                      (ix) The Company shall reasonably cooperate with legal
counsel selected by Consent of the Investors ("Investor Counsel"), which
Investor Counsel shall be Brobeck Phleger & Harrison LLP, in performing the
Company's obligations under this Section 7.1 and shall: (A) permit Investor
Counsel to review and comment upon any offering pursuant to this Section 7.1 and
to review and comment upon (1) the Bridge Registration Statement and the PIPE
Registration Statement prior to its filing with the SEC and (2) all amendments
and supplements thereto (except for Annual Reports on Form 10-K, Quarterly
Reports on Form 10-Q and Current Reports on Form 8-K and any similar or
successor reports) prior to their filing with the SEC; and (B) furnish to
Investor Counsel, without charge, (1) any correspondence from the SEC or the
staff of the SEC to the Company or its representatives relating to any
Registration Statement, (2) promptly after the same is prepared and filed with
the SEC, one copy of any Registration Statement and any amendment(s) thereto,
including financial statements and schedules, all documents incorporated therein
by reference and all exhibits, and (3) upon the effectiveness of any
Registration Statement, one copy of the prospectus included in such Registration
Statement and all amendments and supplements thereto; provided that the Company
will only be responsible for reasonable fees and expenses pursuant to this
Section 7.1(c)(ix).

               (d) Indemnification.

                      (i) The Company will indemnify each Investor, its
officers, directors, employees, partners, affiliates, agents, representatives
and legal counsel, and each person controlling (or deemed controlling) such
Investor within the meaning of the Securities Act, (collectively, the
"Investors' Agents") with respect to which registration, qualification or
compliance has been effected pursuant to this Section 7.1, against all claims,
losses, damages and liabilities (or actions in respect thereof), joint or
several, arising out of or based on (i) any untrue statement (or alleged untrue

                                                                            -39-
<PAGE>

statement) of a material fact contained in any prospectus, offering circular or
other similar document or any amendments or supplements thereto (including any
related registration statement and amendments or supplements thereto,
notification or the like) incident to any such registration, qualification or
compliance, or based on any omission (or alleged omission) to state therein a
material fact required to be stated therein or necessary to make the statements
therein not misleading in the light of the circumstances under which they were
made, or (ii) any violation by the Company of any federal, state or common law
rule or regulation applicable to the Company in connection with any such
registration, qualification or compliance, and will reimburse each Investor, and
each Investors' Agent, for any legal and any other expenses reasonably incurred
in connection with investigating or defending any such claim, loss, damage,
liability or action, as incurred, provided that the Company will not be liable
in any such case to the extent that any such claim, loss, damage, liability or
expense arises out of or is based on any untrue statement or omission based upon
written information furnished to the Company by an instrument duly executed by
such Investor and stated to be specifically for use therein or furnished in
writing by such Investor to the Company in response to a request by the Company
stating specifically that such information will be used by the Company therein.

                      (ii) Each Investor will indemnify the Company, each of its
directors and officers, each legal counsel and independent accountant of the
Company, each person who controls the Company within the meaning of the
Securities Act, any underwriter, and each other Investor, against all claims,
losses, damages and liabilities (or actions in respect thereof) arising out of
or based on any untrue statement (or alleged untrue statement) of a material
fact contained in any such registration statement, prospectus, offering circular
or other similar document, or any omission (or alleged omission) to state
therein a material fact required to be stated therein or necessary to make the
statements therein not misleading in the light of the circumstances under which
they were made, and will reimburse the Company, such directors, and officers,
control persons, underwriter and each other Investor for any legal or any other
expenses reasonably incurred in connection with investigating or defending any
such claim, loss, damage, liability or action, as incurred, in each case to the
extent, but only to the extent, that such untrue statement (or alleged untrue
statement) or omission (or alleged omission) is made in such registration
statement, prospectus, offering circular or other document in reliance upon and
in conformity with written information furnished in writing to the Company by an
instrument duly executed by such Investor and stated to be specifically for use
therein or furnished by such Investor to the Company in response to a request by
the Company stating specifically that such information will be used by the
Company therein; provided, however, that the indemnity agreement provided in
this Section 7.1(d)(ii) shall not apply to amounts paid in settlement of any
such loss, claim, damage, liability or action if such settlement is effected
without the written consent of the Investor, which consent shall not be
unreasonably withheld. In no event shall an Investor's indemnification
obligation exceed the net proceeds received from its sale of Registrable
Securities in such offering.

                      (iii) Each party entitled to indemnification under this
Section 7.1(d) (the "Indemnified Party") shall give notice to the party required
to provide indemnification (the "Indemnifying Party") promptly after such
Indemnified Party has received written notice of any

                                                                            -40-
<PAGE>

claim as to which indemnity may be sought, and shall permit the Indemnifying
Party to assume the defense of any such claim or any litigation resulting
therefrom, provided that counsel for the Indemnifying Party, who shall conduct
the defense of such claim or litigation, shall be approved by the Indemnified
Party (whose approval shall not be unreasonably withheld). The Indemnified Party
may participate in such defense at such party's expense; provided, however, that
the Indemnifying Party shall bear the expense of such defense of the Indemnified
Party if representation of both parties by the same counsel would be
inappropriate due to actual or potential conflicts of interest. The failure of
any Indemnified Party to give notice within a reasonable period of time as
provided herein shall relieve the Indemnifying Party of its obligations under
this Section 7.1(d), but only to the extent that such failure to give notice
shall materially adversely prejudice the Indemnifying Party in the defense of
any such claim or any such litigation. No Indemnifying Party, in the defense of
any such claim or litigation, shall, except with the consent of each Indemnified
Party, consent to entry of any judgment or enter into any settlement which does
not include as an unconditional term thereof the giving by the claimant or
plaintiff to such Indemnified Party of a release from all liability in respect
to such claim or litigation.

                      (iv) If the indemnification provided for in this Section
7.1(d) is held to be unavailable to an Indemnified Party with respect to any
loss, liability, claim, damage or expense referred to therein, then the
Indemnifying Party, in lieu of indemnifying such Indemnified Party hereunder,
shall contribute to the amount paid or payable by such Indemnified Party as a
result of such loss, liability, claim, damage, or expense in such proportion as
is appropriate to reflect the relative fault of the Indemnifying Party on the
one hand and of the Indemnified Party on the other in connection with the
statements or omissions that resulted in such loss, liability, claim, damage or
expense as well as any other relevant equitable considerations; provided, that
in no event shall any contribution by an Investor under this Section 7.1(d)
exceed the net proceeds from the offering received by such Investor. The
relative fault of the Indemnifying Party and of the Indemnified Party shall be
determined by reference to, among other things, whether the untrue or alleged
untrue statement of a material fact or the omission to state a material fact
relates to information supplied by the Indemnifying Party or by the Indemnified
Party and the parties' relative intent, knowledge, access to information, and
opportunity to correct or prevent such statement or omission.

                      (v) The obligations of the Company and each Investor under
this Section 7.1 shall survive the completion of any offering of the Registrable
Securities in a Registration Statement under this Section 7.1, any investigation
made by or on behalf of the Indemnified Party or any officer, director or
controlling Person of such Indemnified Party and will survive the transfer of
securities.

               (e) Information by the Investor. Each Investor shall furnish to
the Company such information regarding such Investor and the distribution
proposed by such Investor as the Company may reasonably request in writing and
as shall be reasonably required in connection with any registration,
qualification or compliance referred to in this Section 7.1.

                                                                            -41-
<PAGE>

               (f) Termination of Registration Rights. All rights and
obligations provided for in this Section 7.1 (except for in Section 7.1(d),
which rights and obligations shall survive) shall terminate on the date on which
the Company has no obligation to maintain the effectiveness of either the Bridge
Registration Statement or the PIPE Registration Statement.

        7.2 Reports Under Securities Exchange Act of 1934. With a view to making
available to the Investors the benefits of Rule 144 promulgated under the
Securities Act ("SEC Rule 144")and any other rule or regulation of the SEC that
may at any time permit Investors to sell securities of the Company to the public
without registration or pursuant to a registration on Form S-3, the Company
agrees to:

               (a) make and keep public information available, as those terms
are understood and defined in SEC Rule 144, at all times so long as the Company
remains subject to the periodic reporting requirements under Sections 13 or
15(d) of the Exchange Act;

               (b) use its best efforts to take such action as is necessary to
enable the Investors to utilize Form S-3 for the sale of their Registrable
Securities;

               (c) file with the SEC in a timely manner all reports and other
documents required of the Company under the Securities Act and the Exchange Act;
and

               (d) furnish to any Investor, so long as the Investor owns any
Registrable Securities, forthwith upon request (i) a written statement by the
Company that it has complied with the reporting requirements of the Securities
Act and the Exchange Act, or that it qualifies as a registrant whose securities
may be resold pursuant to Form S-3, (ii) a copy of the most recent annual or
quarterly report of the Company and such other reports and documents so filed by
the Company, and (iii) such other information as may be reasonably requested in
availing any Investor of any rule or regulation of the SEC which permits the
selling of any such securities without registration or pursuant to such form.

        7.3 Assignment of Rights. The rights to cause the Company to register
Registrable Securities pursuant to Section 7.1 may be assigned by an Investor
only to an Affiliate of such Investor. In the event of such assignment, the
transferee shall furnish the Company written notice of such assignment and agree
in writing to be bound by the obligations of such Investor under this Agreement.

        7.4 Stockholders' Meeting. The Company shall, in accordance with the
laws of the State of Delaware and the Company's certificate of incorporation and
bylaws, use its best efforts to convene a meeting of holders of Common Stock
(the "Stockholders' Meeting") within 21 days (or such other time period that is
mutually agreed to by the consent of the Company and Consent of the Investors)
after the Proxy Statement is declared effective, to consider and vote upon
giving Stockholder Approval. Subject to fiduciary obligations under applicable
law, the board of directors of the Company shall recommend such Stockholder
Approval, shall not withdraw or modify such recommendation and shall solicit
such Stockholder Approval. Without limiting the generality of the

                                                                            -42-
<PAGE>

foregoing, if the board of directors of the Company withdraws or modifies its
recommendation, the Company shall nonetheless cause the Stockholders' Meeting to
be convened and a vote to be taken, and the board of directors may communicate
to the Company's stockholders its basis for such withdrawal or modification.

        7.5 Proxy Statement.

               (a) Not later than September 26, 2002, the Company shall prepare
and file with the SEC a proxy statement meeting the requirements of Section 14
of the Exchange Act and the related rules and regulations thereunder promulgated
by the SEC (the "Proxy Statement") to solicit Stockholder Approval. The Company
shall use its best efforts to have the Proxy Statement declared effective under
the Exchange Act as promptly as reasonably practicable after such filing, and
promptly mail the Proxy Statement to the stockholders of the Company.

               (b) The Company shall keep the Investors apprised of the status
of matters relating to the Proxy Statement and the Stockholders' Meeting,
including promptly furnishing the Investors and their counsel with copies of
notices or other communications related to the Proxy Statement, the
Stockholders' Meeting or the Transactions received by the Company from the SEC
or Nasdaq.

        7.6 Election of Directors.

               (a) The Company will use its best efforts to cause, at the
Closing, (i) two (2) persons designated by Sprout (each a "Sprout Designee") to
be appointed members of the board of directors of the Company, one of whom shall
serve as a Class II Director, and (ii) each of the compensation committee and
the nominating committee to have one (1) of the Sprout Designees as a member.
For so long as the funds managed or advised by Sprout Group (collectively,
"Sprout") hold at least 11,000,000 shares of Common Stock (as adjusted by stock
split, reverse stock split, dividend, reorganization, recapitalization or
otherwise, including, without limitation, the Reverse Stock Split) purchased by
Sprout pursuant to the Transactions, the Company shall use its best efforts to
cause (i) both of the Sprout Designees to be nominated and elected to the board
of directors of the Company in any election of directors, and (ii) if any of the
Sprout Designees who has been elected to the board of directors of the Company
shall cease for any reason to be a member of the board of directors of the
Company during such person's term as a director, then the Company shall use its
best efforts, subject to applicable laws and regulations, to cause such vacancy
to be filled by a replacement designated by Sprout, and such designee shall be a
Sprout Designee for purposes of this Agreement. For so long as Sprout holds at
least 5,500,000 shares of Common Stock (as adjusted by stock split, reverse
stock split, dividend, reorganization, recapitalization or otherwise, including,
without limitation, the Reverse Stock Split) purchased by Sprout pursuant to the
Transactions, the Company shall use its best efforts to cause (i) one of the
Sprout Designees to be nominated and elected to the board of directors of the
Company in any election of directors, and (ii) if the Sprout Designee who has
been elected to the board of directors of the Company shall cease for any reason
to be a member of the board of directors of the Company during such person's
term as a director, then the Company shall use its best efforts, subject to
applicable laws and regulations, to cause such

                                                                            -43-
<PAGE>

vacancy to be filled by a replacement designated by Sprout, and such designee
shall be the Sprout Designee for purposes of this Agreement. For so long as any
Sprout Designee remains a member of the board of directors, then the
compensation committee, the nominating committee and any committee that
exercises substantial control over the Company or its operations will include a
Sprout Designee.

               (b) The Company shall use its best efforts to cause, at the
Closing, (i) one (1) person designated by IGC (the "IGC Designee") to be
appointed a member of the board of directors, to serve as a Class I Director,
and (ii) such IGC Designee to be a member of the nominating committee and the
compensation committee. For so long as the funds managed or advised by Investor
Growth Capital (collectively, "IGC") hold at least 5,500,000 shares of Common
Stock (as adjusted by stock split, reverse stock split, dividend,
reorganization, recapitalization or otherwise, including, without limitation,
the Reverse Stock Split) purchased by IGC pursuant to the Transactions, the
Company shall use its best efforts to cause (i) an IGC Designee to be nominated
and elected to the board of directors of the Company in any election of
directors, and (ii) if an IGC Designee who has been so elected to the board of
directors of the Company shall cease for any reason to be a member of the board
of directors of the Company during such person's term as a director, then the
Company shall use its best efforts, subject to applicable laws and regulations,
to cause such vacancy to be filled by a replacement designated by IGC, and such
designee shall be the IGC Designee for purposes of this Agreement. For so long
as an IGC Designee remains a member of the board of directors, the Company shall
use its best efforts to appoint such IGC Designee to be a member of the
compensation committee, the nominating committee and any committee of the board
of directors that exercises substantial control over the Company or its
operations will include the IGC Designee.

               (c) The Company will use its best efforts to cause, at the
Closing, (i) one (1) person designated by Sanderling (the "Sanderling Designee")
to be appointed a member of the board of directors of the Company, to serve as a
Class III Director, and (ii) such Sanderling Designee to be a member of the
nominating committee. For so long as the funds managed or advised by Sanderling
Venture Partners (collectively, "Sanderling") hold at least 5,500,000 shares of
Common Stock (as adjusted by stock split, reverse stock split, dividend,
reorganization, recapitalization or otherwise, including, without limitation,
the Reverse Stock Split) purchased by Sanderling pursuant to the Transactions,
(i) the Company shall use its best efforts to cause the Sanderling Designee to
be nominated and elected to the board of directors of the Company in any
election of directors, and (ii) if a Sanderling Designee who has been so elected
to the board of directors of the Company shall cease for any reason to be a
member of the board of directors of the Company, then the Company shall use its
best efforts, subject to applicable laws and regulations, to cause such vacancy
to be filled by a replacement designated by Sanderling, and such designee shall
be the Sanderling Designee for purposes of this Agreement. For so long as a
Sanderling Designee remains on the board of directors of the Company, the
compensation committee and any committee exercising substantial control over the
Company or its operations shall include a Sanderling Designee.

                                                                            -44-
<PAGE>

               (d) The board of directors of the Company immediately following
the Closing will have three vacancies and six members for a total of nine
authorized directors.

        7.7 Nasdaq Listing. The Company shall file a listing application with
Nasdaq for the Registrable Securities held by the Investors and use its best
efforts to maintain the listing of its Common Stock on Nasdaq (or a comparable
system then in use) or the New York Stock Exchange or other national exchange
for a period of not less than three years from the date of issuance.

        7.8 Purchase in Event of No Stockholder Approval.

               (a) In the event that Stockholder Approval is not obtained by
November 18, 2002 (the "Non-Approval Event"), then (i) at any time during the
period from the Non-Approval Event to December 31, 2002 (the "Final Date"), the
Investors may, at their option, purchase from the Company, and the Company shall
sell to such Investors, each such Investor's Pro Rata Portion of the maximum
number of shares of Common Stock permitted without violating NASD Rules, and
(ii) promptly after the Non-Approval Event, the Company shall apply to Nasdaq
for, and shall use its best efforts to obtain from Nasdaq, permission to sell to
the Investors the maximum additional number of shares of Common Stock permitted
without violating any applicable NASD Rule, including by exemption under NASD
Rule 4350(i)(2), through any of the following or combination thereof: (w)
conversion of the Bridge Notes, (x) the exercise of Bridge Warrants, (y) the
sale and purchase of Common Stock for cash on the terms set forth herein, or (z)
the issuance and exercise of Warrants on the terms set forth herein.

               (b) If Nasdaq permits the purchase and sale of additional shares
of Common Stock, then at any time during the period from such Nasdaq permission
to the Final Date, the Investors may, at their option, purchase from the
Company, and the Company shall sell to the Investors, each such Investor's Pro
Rata Portion (as defined below) of the maximum number of additional shares of
Common Stock so permitted. Each Investor shall also have a right of
over-allotment such that if any Investor fails to fully exercise its right
hereunder to purchase its Pro Rata Portion of the shares of Common Stock the
Company is permitted to sell as set forth in Section 7.8(a) above, each of the
other Investors may purchase on a pro rata basis, subject to any applicable NASD
Rule, the portion of such non-purchasing Investor's Pro Rata Portion of such
shares of Common Stock (the "Remaining Share"). "Pro Rata Portion" for purposes
of this Section 7.8 is the ratio of (x) the number of Common Shares issued or
issuable to such Investor pursuant to Section 2.1 herein and pursuant to full
conversion of such Investor's Bridge Notes and full exercise of such Investor's
Bridge Warrants, and Warrants, to (y) the total number of Common Shares issued
or issuable to all Investors pursuant to Section 2.1 herein and pursuant to full
conversion of all Investors' Bridge Notes and full exercise of all Investors'
Bridge Warrants and Warrants. In the event the Company undertakes an issuance of
Common Stock pursuant to this Section 7.8, it shall provide written notice to
each Investor of (i) the total number of shares of Common Stock it is permitted
to sell and (ii) each Investor's Pro Rata Portion of the offering. The Investors
shall have fifteen (15) days from the date of receipt of any such notice to
agree to purchase shares of Common Stock by giving written notice to the Company
and stating therein the quantity of Common Stock to

                                                                            -45-

<PAGE>

be purchased. The Investors shall specify in its notification to the Company
whether, and the extent to which, it also elects to purchase any Investor's
Remaining Share.

        7.9 Financial Results. On the fifth Business Day of each month, the
Company shall provide to each Investor a report as to the Company's actual
consolidated financial results for the prior month with respect to (i) the
aggregate balance of cash and cash equivalents of the Company and its
Subsidiaries as of the end of such prior month and the projected aggregate
balance of cash and cash equivalents of the Company and its Subsidiaries at the
end of such period and (ii) the actual expenses of the Company and its
Subsidiaries for such period versus the projected expenses of the Company and
its Subsidiaries for such period. The projected cash balance and the projected
expenses shall be determined by reference to the forecasts provided by the
Company to each Investor on September 16, 2002 (the "FORECAST," a copy of which
is attached to each Bridge Note). The Company shall give each Investor prompt
written notice of any known material deviation from the Forecast. The Company
shall not permit (i) its actual expenses for any month to exceed the projected
expenses for such period (as set forth in the Forecast) by $100,000 or more or
(ii) its actual balance of cash and cash equivalents at the end of any month to
be less than the projected balance of cash and cash equivalents (as set forth in
the Forecast) by more than $100,000. Expenses and cash and cash equivalents
shall be determined in accordance with GAAP consistently applied.

        7.10 Lock-Up. The Company shall use reasonable efforts to enter into an
agreement, and shall not amend, modify or waive, either directly or indirectly,
any term thereof, with each officer and director of the Company, each Person
holding 5% or more of the Fully Diluted Shares as of the date hereof or as of
the Closing, and each Investor (each such officer, director, Person and Investor
being a "Holder"), prior to the Closing Date, which agreement shall provide that
each such Holder shall not, directly or indirectly sell, offer to sell, contract
to sell (including any short sale), grant any option to purchase or otherwise
transfer, dispose of or decrease its beneficial interest in (other than to
donees, distributees and Affiliates who agree to be similarly bound) any
securities of the Company held by it for a period of 180 days following the
Closing Date (the "Lock-Up Period").

        7.11 D&O Insurance. Promptly following the date hereof and prior to the
Appointment Time, the Company shall take all reasonable actions required to
cause each director appointed or elected to the Company's board of directors
pursuant to Section 7.6 to be fully covered by the Company's existing directors'
and officers' liability insurance, to the same extent as the Company's directors
as of the date hereof, effective automatically as of the Appointment Time and
without further action by any director so appointed or elected.

        7.12 Indemnification Agreements. Promptly following the date hereof and
prior to the Appointment Time, the Company shall execute indemnification
agreements in substantially the form of Exhibit E attached hereto (the
"Indemnification Agreements") with each Investor, each director appointed or
elected to the Company's board of directors pursuant to Section 7.6, and each
incumbent director in office as of the Appointment Time.

        7.13 Board of Directors; Powers; Committees. As of the Closing Date, the
bylaws of the Company will have been amended in accordance with its terms, to
provide the following:

                                                                            -46-
<PAGE>

               (a) The board of directors will have nine (9) members.

               (b) The board of directors shall have an audit committee, the
composition and duties of which shall be in compliance with all applicable
federal and state securities laws and NASD Rules, and which shall consist of
three (3) members of the board of directors.

               (c) The board of directors shall have a nominating committee, the
composition and duties of which shall be in compliance with all applicable
federal and state securities laws and NASD Rules, and which shall consist of
three (3) members of the board of directors. The duties of the nominating
committee will include (i) recommending to the board of directors for approval
pursuant to Section 7.13(e)(vii) herein, the hiring and termination of any
executive officer of the Company, including the Chief Executive Officer and
Chief Financial Officer, and (ii) nominating any new member of the board of
directors.

               (d) The board of directors shall have a compensation committee,
the composition and duties of which shall be in compliance with all applicable
federal and state securities laws and NASD Rules, and which shall consist of
three (3) members of the board of directors. The duties of the compensation
committee will include (i) authorizing the compensation of any executive
officer, (ii) setting number of shares reserved under the Company's option pool,
and (iii) setting employee compensation guidelines.

               (e) After the Closing, the Company will not, without the approval
of a majority of the whole board of directors (i.e., a majority of the total
number of directors then in office):

                      (i) Authorize, offer, sell, or issue any equity or debt
securities of the Company or any Subsidiary of the Company.

                      (ii) Incur indebtedness for borrowed money or guarantee or
act as a surety for any debt which individually or in the aggregate is in excess
of One Million Dollars ($1,000,000).

                      (iii) Grant a security interest in assets of the Company
or any Subsidiary of the Company which individually or in the aggregate have a
value in excess of Five Hundred Thousand Dollars ($500,000).

                      (iv) Sell, lease, sublease, license or otherwise transfer
any of the rights, title and interest in any material Company Intellectual
Property or any Company Intellectual Property, whether or not material, relating
to pharmaceuticals or biologics.

                      (v) Purchase, license or otherwise acquire any of the
rights, title or interest in any material Intellectual Property of any third
party relating to pharmaceuticals or biologics.

                      (vi) Approve any annual business plan or budget or any
material revisions thereto.

                                                                            -47-
<PAGE>

                      (vii) Hire or terminate any executive officer of the
Company, including the Chief Executive Officer and Chief Financial Officer.

        7.14 Board Observers. From the date of this Agreement until the Closing,
a representative (who shall be acceptable to the Company in its reasonable
judgment) of each of Sprout and IGC (each an "Observer"), shall have the right
to attend all meetings of the board of directors of the Company in a nonvoting
observer capacity, to receive notice of such meeting and to receive the
information provided by the Company to the board of directors; provided,
however, that the Company reserves the right to withhold any information and to
exclude any Observer from any meeting or portion thereof (so long as the Company
notifies such Observer of such withholding) if access to such information or
attendance at such meeting would in the good faith determination of the board of
directors (a) adversely affect the attorney-client privilege between the Company
and its counsel or cause the board of directors to breach its fiduciary duties,
(b) result in a conflict of interest or potential conflict of interest with the
Company, or (c) impair the Company's ability to enforce its rights under this
Agreement or the Bridge Loan Agreement in any bona fide dispute with the
Observer. The Company will use its best efforts to ensure that any withholding
of information or any restriction on attendance is strictly limited only to the
extent necessary set forth in the preceding sentence. Each Observer agrees to
hold all information received pursuant to this Section 7.14 in confidence, to
enter into a reasonable confidentiality agreement with the Company, and not to
use or disclose any of such information to any third party, except to the extent
such information is known, or when such information becomes known, to the public
(other than as a result of a breach of this sentence by any Observer) (such
non-public information, "Confidential Information"); provided, however, that an
Observer may disclose Confidential Information (i) to its attorneys,
accountants, consultants, and other professionals in connection with its or its
Affiliates' investment in the Company, (ii) as may otherwise be required by law,
provided that such Observer takes reasonable steps to minimize the extent of any
such required disclosure, or (iii) to the extent necessary to enforce against
the Company this Agreement or the other agreements contemplated hereby or
executed herewith. The Company recognizes that certain of the Observers or their
Affiliates are engaged in the business of providing venture capital financing
and management advice to companies in which they invest (the "Venture
Investors"), and that in their business the Venture Investors may seek to invest
in and/or provide advice to companies that may be competitive with the Company.
Accordingly, notwithstanding anything to the contrary in this Agreement, the
Company understands and agrees that nothing in this Agreement will restrict the
Venture Investors from investing or participating in the management of any
business or entity which competes or may compete, directly or indirectly, with
the Company so long as such Venture Investor does not disclose any Confidential
Information to such business or entity or help or otherwise assist such business
or entity to use such information in violation hereof. The Company further
agrees that, provided a Venture Investor does not disclose Confidential
Information to a third-party in violation hereof, such Venture Investor shall be
free to use for internal use in its business any information it has obtained or
will obtain from the Company; provided, however, that any recipient of such
information is similarly restricted with respect to Confidential Information;
and provided, further, such Venture Investor shall not disclose any such
information to an officer, director, Affiliate, employee, or significant
stockholder of any

                                                                            -48-
<PAGE>

business or entity that competes or may reasonably be deemed to compete,
directly or indirectly, with the Company.

        7.15 Indemnification. The Company will, to the fullest extent permitted
by law, defend each Investor, and each of its Affiliates, directors, officers,
agents and employees (the "Investor Indemnitees") or settle (provided that the
Company will not agree to any settlement without the Investor Indemnitee's prior
written consent, which consent shall not be unreasonably withheld) at the
Company's expense any Action or Proceeding (as defined below) arising out of or
in connection with a breach of any representations, warranties or covenants of
the Company in this Agreement. The Company will indemnify and hold harmless the
Investor Indemnitees from and against any and all damages, costs, liabilities
and attorneys' fees, incurred in defending and/or resolving such Action or
Proceeding; provided, that (i) the Company is promptly notified in writing of
such Action or Proceeding (provided that any failure to deliver such notice will
not relieve the Company of liability under this Section 7.15 except to the
extent such failure is materially prejudicial to the Company's ability to defend
such Action or Proceeding), (ii) the Company will have the sole control of the
defense and/or settlement thereof (provided that, if representation of the
Investor Indemnitees by counsel retained by the Company would be inappropriate
due to any actual or potential differing interest between the Investor
Indemnitee and the Company or any third party represented by such counsel, the
Investor Indemnitees will have the right to retain one separate counsel, with
reasonable fees and expenses to be paid by the Company), (iii) the Investor
Indemnitees furnish to the Company, on request, information available to the
Investor Indemnitees for such defense, (iv) the Investor Indemnitees reasonably
cooperate in any defense and/or settlement thereof as long as the Company pays
all of the Investor Indemnitees' reasonable out of pocket expenses and
attorneys' fees; and (v) the Company shall have no indemnification obligations
pursuant to this section until the aggregate amount of such damages, costs,
liabilities and attorneys' fees with respect to all Investor Indemnitees exceeds
$100,000 in the aggregate, in which case such Investor Indemnitee shall be
entitled to recover the full amount of all costs, liabilities and attorneys'
fees. The Investor Indemnitees will not admit any such Action or Proceeding or
any allegations made in such Action or Proceeding without the prior written
consent of the Company (which will not be unreasonably withheld). For purposes
of this Agreement, an "Action or Proceeding" means any action, suit, litigation,
proceeding, mediation, arbitration or investigation or audit by any Person.

        7.16 Operation of Business. The Company agrees that, between the date of
this Agreement and the earlier of the termination of this Agreement and the
Closing Date, except as expressly contemplated by any provision of this
Agreement, (i) the business of the Company shall be conducted only in, and the
Company shall not take any action except in, the ordinary course of business
consistent with past practice, and (ii) the Company shall use its commercially
reasonable efforts to preserve its business organization intact, to keep
available the services of its current officers and employees and to maintain its
existing relations with suppliers, creditors, business partners and others
having business dealings with the Company, to the end that the Company's
goodwill and ongoing business shall be unimpaired at the Closing Date.

                                                                            -49-
<PAGE>

        7.17 No-Solicitation. Neither the Company nor any of its Subsidiaries or
controlled Affiliates shall (and the Company shall direct the officers,
directors, employees, representatives and agents, including investment bankers,
attorneys and accountants (the "Representatives") of the Company, its
Subsidiaries or controlled Affiliates, not to) directly or indirectly, solicit,
engage in, or initiate (including by way of furnishing or disclosing non-public
information) or take any action intended to facilitate or encourage any
inquiries, negotiations, discussions, or the making of any proposals with
respect to or concerning any Acquisition Proposal. Upon receipt of an
Acquisition Proposal that the Board of Directors of the Company believes in good
faith, following consultation with its outside financial and legal advisers, may
require the Board of Directors of the Company, pursuant to its fiduciary duties
under applicable law, to withdraw or modify its recommendation in favor of the
Transactions, the Company shall be allowed to make one request for additional,
solely clarifying information from the Person making the Acquisition Proposal
for the sole purpose of determining whether to maintain, withdraw or modify its
recommendation in favor of the Transactions (the "Clarifying Request"); provided
that the Clarifying Request shall only be made in writing, and the Company
shall, at the same time as the Clarifying Request is delivered to the Person
making the Acquisition Proposal, provide a true, accurate, and complete copy of
the Clarifying Request to the Investors and their counsel. Nothing herein shall
be construed as permitting the Company or any of its Subsidiaries or controlled
Affiliates (or any of its or their Representatives) to engage in negotiation or
discussion with or to make any proposal to the Person making the Acquisition
Proposal (or any of such Person's Representatives) regarding any Acquisition
Proposal. For purposes of this section, "Acquisition Proposal" means any
proposal or offer (a) from any Person other than the Investors or their
Affiliates to acquire (i) all or substantially all of the business or properties
of the Company or any of its Subsidiaries, or (ii) fifteen percent (15%) or more
of the capital stock or other equity interests in the Company or any of its
Subsidiaries, whether by sale of stock or assets, merger, consolidation, other
business combination, tender offer or exchange offer, recapitalization,
reorganization, liquidation, dissolution or other transaction involving the
Company, any of its Subsidiaries, any division or operating or principal
business unit of the Company or any of its Subsidiaries, on the one hand, and
any other Person, on the other hand.

        7.18 Reasonable Efforts; Notification; Representations. Subject to the
other terms and conditions of this Agreement, each of the parties to this
Agreement shall use reasonable efforts to take promptly, or cause to be taken,
all actions, and to do promptly, or cause to be done, all things necessary,
proper or advisable under applicable laws and regulations to consummate and make
effective the Transactions contemplated by this Agreement. Each party to this
Agreement shall give prompt notice to each other party to this Agreement upon
becoming aware that any representation or warranty made by such party in this
Agreement has become untrue or inaccurate or that such party has failed to
comply with or satisfy in any material respect any covenant, condition or
agreement to be complied with or satisfied by such party under this Agreement,
in each case such that the conditions set forth in Section 5.1 or Section 6.1,
as the case may be, would not be satisfied. No party to this Agreement shall
take any action that would cause any representation or warranty made by such
party in this Agreement to be untrue if made at Closing.

                                                                            -50-
<PAGE>

        7.19 Termination. The covenants of the Company set forth in this Section
7 (other than the covenants in Sections 7.1, 7.11 and 7.12 and the covenants
which terminate earlier as specifically set forth in such covenant) shall
terminate on the earlier to occur of (i) the fifth anniversary of the Closing
Date, and (ii) with respect to each Investor, the date on which such Investor
and its respective Affiliates beneficially own less than 1,000,000 shares of
Common Stock (as adjusted for stock splits, stock dividends, recapitalizations
and the like, including the Reverse Stock Split).

                                    Section 8

                                   Termination

        8.1 Termination Events. Without prejudice to other remedies which may be
available to the parties by law or this Agreement, this Agreement may be
terminated and the transactions contemplated hereby may be abandoned at any time
prior to the Closing:

               (a) Mutually, by the written consent of the Company and Consent
of the Investors;

               (b) by either the Company or Consent of the Investors by giving
written notice to the other party or parties if the Closing shall not have
occurred prior to December 31, 2002, unless extended by written agreement of the
parties; provided that the party seeking termination pursuant to this subsection
(b) is not in default or breach hereunder and provided, further, that the right
to terminate this Agreement under this subsection (b) shall not be available (i)
to any party whose failure to fulfill any obligation under this Agreement has
been the cause of, or resulted in, the failure of the Closing to occur on or
before such date or (ii) in the event that the Closing shall not have occurred
as a result of a failure of any representation to be true and correct and the
party seeking termination knew of such breach prior to the date of this
Agreement;

               (c) by either the Company or Consent of the Investors by giving
written notice to the other party or parties if any Governmental Entity shall
have issued an injunction or other ruling prohibiting the consummation of any of
the transactions contemplated by this Agreement and such injunction or other
ruling shall not be subject to appeal or shall have become final and
unappealable;

               (d) by either the Company or Consent of the Investors in the
event that Stockholder Approval is not obtained at the Stockholders' Meeting; or

               (e) by any Investor Group entitled to purchase less than 10% of
the Common Shares pursuant to Section 2.1 herein if within 2 Business Days
following receipt of a notice of the Consent of the Investors, the controlling
Affiliate of either or both of such Investor Groups delivers to the Company and
to the controlling Affiliate of each other Investor Group a notice of
termination under this Section 8.1(e); provided that such termination shall be
with respect only to the rights and obligations between such Investor Group(s)
or any subset of Investors therein to which the termination notice is
applicable, on the one hand, and the Company and each other Investor, on the

                                                                            -51-
<PAGE>

other, and shall in no event be with respect to the rights and obligations (i)
among the other Investors or (ii) between the other Investors on the one hand,
and the Company on the other.

        8.2 Effect of Termination. In the event of any termination of this
Agreement pursuant to Section 8.1, all rights and obligations of the parties
hereunder shall terminate without any liability on the part of any party or its
Subsidiaries and Affiliates in respect thereof; provided, however, that such
termination shall not relieve the Company or any Investor of any liability for
any breach of this Agreement; provided, further, that the Company's obligations
to register the Bridge Registrable Securities pursuant to Section 7.1 shall
survive termination of this Agreement unless otherwise agreed to by all of the
Bridge Investors.

                                    Section 9

                                  Miscellaneous

        9.1 Waivers and Amendments. Any provision of this Agreement may be
amended, waived or modified only upon the written consent of the Company and
Consent of the Investors; except that no amendment, waiver or modification of
this Section 9.1, the definition of Consent of the Investors, any provision of
the Schedule of Investors on Exhibit A hereto, the form of Warrant annexed as
Exhibit B hereto, or any of the conditions to the Investors' obligations set
forth herein in Section 5, and no amendment, waiver or modification of any
provision of this Agreement which is detrimental to any Investor in a manner
materially different from any other Investor, shall be made without the consent
of each affected Investor. Any amendment or waiver effected in accordance with
this Section 9.1 shall be binding upon each Investor and the Company.

        9.2 Governing Law. This Agreement shall be governed in all respects by
and construed in accordance with the laws of the State of Delaware without any
regard to conflicts of laws principles.

        9.3 Waiver of Jury Trial; Trial Costs. Each of the Company, for itself
and its Affiliates, and Investors hereby irrevocably waive all right to trial by
jury in any action, proceeding or counterclaim (whether based on contract, tort
or otherwise) arising out of or relating to the actions of the Company and the
Investors or their Affiliates pursuant to this Agreement in the negotiation,
administration, performance or enforcement thereof. The party in whose favor a
final judgment is rendered shall be entitled to reasonable costs and reasonable
attorneys' fees.

        9.4 Survival. The representations and warranties made in this Agreement
shall survive the Closing, and all covenants and agreements shall survive until
performed or waived, unless terminated sooner pursuant to the terms of this
Agreement.

        9.5 Successors and Assigns. The provisions hereof shall inure to the
benefit of, and be binding upon, the successors, assigns, heirs, executors and
administrators of the parties to this Agreement. Neither the Company nor the
Investors may assign, except as expressly contemplated

                                                                            -52-

<PAGE>

herein, any rights, obligations or benefits under this Agreement without the
prior written consent of the other party.

        9.6 Entire Agreement. This Agreement, including all exhibits, hereto
constitutes the full and entire understanding and agreement between the parties
with regard to the subjects hereof and thereof.

        9.7 Notices, etc. All notices and other communications required or
permitted under this Agreement shall be effective upon receipt and shall be in
writing and may be delivered in person, by telecopy, overnight delivery service
or registered or certified United States mail, addressed:

        If to the Company:              Vicente Anido, Jr., PhD.
                                        Chief Executive Officer
                                        15279 Alton Parkway, #100
                                        Irvine, CA  92618
                                        Facsimile:  (949) 789-7744

        With a courtesy copy to:        Issac J. Vaughn, Esq.
                                        Wilson Sonsini Goodrich & Rosati
                                        650 Page Mill Rd.
                                        Palo Alto, CA  94304
                                        Facsimile:  (650) 493-9811

        If to the Investor:             The address set forth
                                        next to such Investor's name in Exhibit
                                        A.

        with a courtesy copy to:        Warren T. Lazarow, Esq.
                                        Brobeck, Phleger & Harrison LLP
                                        2000 University Avenue
                                        East Palo Alto, CA 94303
                                        Facsimile:  (650) 331-8107

        All notices and other communications shall be effective upon the earlier
of actual receipt thereof by the person to whom notice is directed or (i) in the
case of notices and communications sent by personal delivery or telecopy, one
Business Day after such notice or communication arrives at the applicable
address or was successfully sent to the applicable telecopy number, (ii) in the
case of notices and communications sent by overnight delivery service, at noon
(local time) on the second Business Day following the day such notice or
communication was sent, and (iii) in the case of notices and communications sent
by United States mail, seven days after such notice or communication shall have
been deposited in the United States mail.

        9.8 Interpretation. When a reference is made in this Agreement to
Exhibits or Schedules, such reference shall be to an Exhibit or Schedule to this
Agreement unless otherwise indicated. The words "include," "includes" and
"including" when used in this Agreement shall be deemed in each

                                                                            -53-

<PAGE>

case to be followed by the words "without limitation." The phrase "provided to,"
"furnished to," and terms of similar import in this Agreement means that a paper
copy of the information referred to has been furnished to the party to whom such
information is to be provided. In this Agreement, the phrases "the date of this
Agreement", "the date hereof", and terms of similar import, unless the context
otherwise requires, shall be deemed to refer to September 19, 2002. The table of
contents and headings contained in this Agreement are for reference purposes
only and shall not affect in any way the meaning or interpretation of this
Agreement.

        9.9 Severability of this Agreement. Whenever possible, each provision of
this Agreement shall be interpreted in such manner as to be valid, legal, and
enforceable under all applicable laws and regulations. If, however, any
provision of this Agreement shall be invalid, illegal, or unenforceable under
any such law or regulation in any jurisdiction, it shall, as to such
jurisdiction, be deemed modified to conform to the minimum requirements of such
law or regulation, or, if for any reason it is not deemed so modified, it shall
be invalid, illegal, or unenforceable only to the extent of such invalidity,
illegality, or limitation on enforceability without affecting the remaining
provisions of this Agreement, or the validity, legality, or enforceability of
such provision in any other jurisdiction.

        9.10 Counterparts. This Agreement may be executed in any number of
counterparts, each of which shall be an original, but all of which together
shall constitute one instrument.

        9.11 Further Assurances. Each party to this Agreement shall do and
perform or cause to be done and performed all such further acts and things and
shall execute and deliver all such other agreements, certificates, instruments
and documents as the other party hereto may reasonably request in order to carry
out the intent and accomplish the purposes of this Agreement and the
consummation of the transactions contemplated hereby.

        9.12 Public Announcements. Except as may be required by law or
regulation, the Company shall not use the name of, or make reference to, any
Investor or any of its Affiliates in any press release or in any public manner
(including any reports or filings made by the Company under the Exchange Act)
without such Investor's prior written consent which consent shall not be
unreasonably withheld. The initial press release with respect to the execution
of this Agreement shall be approved by the Company and Sprout, IGC and
Sanderling on behalf of the Investors. Thereafter, so long as this Agreement is
in effect, the Company and the Investors shall consult with each other before
issuing any press release or otherwise making any public statements with respect
to this Agreement or the Transactions without the prior consent of the other
party, which consent shall not be unreasonably withheld; provided, however, that
the Company, on the one hand, and the Investors, on the other hand, may, without
the prior consent of the other party, issue a press release or make such public
statement as may, upon the advice of counsel, be required by law if it has used
all reasonable efforts to consult with the other party.

        9.13 Expenses. The Company shall bear its own expenses and shall,
subject to the Closing, pay the reasonable fees and expenses of one legal
counsel to the Investors incurred with

                                                                            -54-
<PAGE>

respect to this Agreement and the Transactions, as well as the Bridge Loan
Agreement and the transactions contemplated thereby.

        9.14 California Commissioner of Corporations. THE SALE OF THE SECURITIES
THAT IS THE SUBJECT OF THIS AGREEMENT HAS NOT BEEN QUALIFIED WITH THE
COMMISSIONER OF CORPORATIONS OF THE STATE OF CALIFORNIA, THE ISSUANCE OF SUCH
SECURITIES OR THE PAYMENT OR RECEIPT OF ANY PART OF THE CONSIDERATION FOR SUCH
SECURITIES PRIOR TO SUCH QUALIFICATION IS UNLAWFUL, UNLESS THE SALE OF
SECURITIES IS EXEMPT FROM THE QUALIFICATION BY SECTION 25100, 25102 OR 25105 OF
THE CALIFORNIA CORPORATIONS CODE. THE RIGHTS OF ALL PARTIES TO THIS AGREEMENT
ARE EXPRESSLY CONDITIONED UPON SUCH QUALIFICATION BEING OBTAINED UNLESS THE SALE
IS SO EXEMPT.

                            [Signature pages follow]

                                                                            -55-
<PAGE>

        The foregoing agreement is hereby executed as of the date first above
written.

                                       "COMPANY"

                                       ISTA PHARMACEUTICALS, INC.

                                       a Delaware corporation

                                       By:
                                           -------------------------------------
                                           Vicente Anido, Jr., Ph.D.
                                           President and Chief Executive Officer

<PAGE>

                                   "INVESTORS"

                                SANDERLING VENTURE PARTNERS V CO-INVESTMENT
                                FUND, L.P.
                                By:  Middleton, McNeil & Mills Associates V, LLC

                                By:
                                  ----------------------------------------------
                                  Name:   Robert G. McNeil
                                       -----------------------------------------
                                  Title:  Managing Director
                                       -----------------------------------------

<PAGE>

                                "INVESTORS"

                                SANDERLING V BIOMEDICAL CO-INVESTMENT FUND, L.P.
                                By:  Middleton, McNeil & Mills Associates V, LLC

                                By:
                                  ----------------------------------------------
                                  Name:   Robert G. McNeil
                                       -----------------------------------------
                                  Title:  Managing Director
                                       -----------------------------------------

<PAGE>

                                "INVESTORS"

                                SANDERLING V LIMITED PARTNERSHIP
                                By:  Middleton, McNeil & Mills Associates V, LLC

                                By:
                                  ----------------------------------------------
                                  Name:   Robert G. McNeil
                                       -----------------------------------------
                                  Title:  Managing Director
                                       -----------------------------------------

<PAGE>

                                "INVESTORS"

                                SANDERLING V BETEILIGUNGS GMBH & CO. KG
                                By:  Middleton, McNeil & Mills Associates V, LLC

                                By:
                                  ----------------------------------------------
                                  Name:   Robert G. McNeil
                                       -----------------------------------------
                                  Title:  Managing Director
                                       -----------------------------------------

<PAGE>

                                "INVESTORS"

                                SANDERLING V VENTURES MANAGEMENT

                                By:
                                  ----------------------------------------------
                                  Name:   Robert G. McNeil
                                       -----------------------------------------
                                  Title:  Owner
                                       -----------------------------------------

<PAGE>

                                        "INVESTORS"

                                        DONALDSON, LUFKIN & JENRETTE SECURITIES
                                        CORPORATION
                                        AS NOMINEE FOR:
                                        DLJ FIRST ESC, L.P.
                                        EMA 2001 PLAN, L.P.
                                        CSFB 2001 INVESTORS, L.P.
                                        CREDIT SUISSE FIRST BOSTON PRIVATE
                                        EQUITY, INC.
                                        DOCKLANDS 2001 PLAN, L.P.
                                        PARADEPLATZ 2001 PLAN, L.P.

                                        By:
                                           -------------------------------------
                                        Name:  Kathleen D. LaPorte
                                        Title: Attorney in fact

<PAGE>

                                        "INVESTORS"

                                        SPROUT ENTREPRENEURS' FUND, L.P.
                                            By:  DLJ Capital Corp.
                                            Its:  General Partner

                                        By:
                                           -------------------------------------
                                        Name:  Kathleen D. LaPorte
                                        Title: Managing Director

<PAGE>

                                        "INVESTORS"

                                        SPROUT CAPITAL IX, L.P.
                                           By:  DLJ Capital Corporation
                                           Its: General Partner

                                        By:
                                           -------------------------------------
                                        Name:  Kathleen D. LaPorte
                                        Title: Managing Director

<PAGE>

                                        "INVESTORS"

                                        INVESTOR GROWTH CAPITAL LIMITED

                                        By:
                                           -------------------------------------
                                        Name:
                                        Title:

<PAGE>

                                        "INVESTORS"

                                        INVESTOR GROUP L.P.

                                        By:
                                           -------------------------------------
                                        Name:
                                        Title:

<PAGE>

                                        "INVESTORS"

                                        KBL HEALTHCARE, LP

                                        By:
                                           -------------------------------------
                                           Name:  Marlene Krauss
                                           Title: Managing Director

<PAGE>

                                        "INVESTORS"

                                        KBL PARTNERSHIP, LP

                                        By:
                                           -------------------------------------
                                           Name:  Marlene Krauss
                                           Title: Managing Director

<PAGE>

                                        "INVESTORS"

                                        ----------------------------------------

                                        By:
                                           -------------------------------------
                                        Name:
                                        Title:

<PAGE>

                                    EXHIBIT A

                              SCHEDULE OF INVESTORS

<TABLE>
<CAPTION>
-----------------------------------------------------------------------------------------------------------------------------------
                            INVESTOR                                 ADDRESS AND FACSIMILE NUMBER                 INVESTMENT AMOUNT
------------------------------------------------------------------------------------------------------------------------------------
<S>                                                              <C>                                              <C>
Sanderling Entities (includes Sanderling Venture Partners V      400 S. El Camino Real, Suite 1200                 $ 3,300,000.00
      Co-Investment Fund, L.P., Sanderling V Biomedical          San Mateo, CA  94402
      Co-Investment Fund, L.P., Sanderling V Limited             Attention:  Andrew Lenz
      Partnership, Sanderling V Beteiligungs GmbH & Co. KG,      Fax: (650) 375-7077
      Sanderling V Ventures Management; investment allocation
      between Sanderling Entities will be determined prior to
      closing)
------------------------------------------------------------------------------------------------------------------------------------
Donaldson, Lufkin & Jenrette Securities Corp.                    Donaldson, Lufkin & Jenrette Securities Corp.     $   778,244.00
                                                                 c/o Sprout Group
                                                                 11 Madison Avenue
                                                                 13th Floor
                                                                 New York, New York  10010
                                                                 Fax:  (212) 538-8245
------------------------------------------------------------------------------------------------------------------------------------
Sprout Entrepreneurs' Fund, L.P.                                 Sprout Entrepreneurs' Fund, L.P.                  $    60,929.00
                                                                 c/o Sprout Group
                                                                 11 Madison Avenue
                                                                 13th Floor
                                                                 New York, New York  10010
                                                                 Fax:  (212) 538-8245
------------------------------------------------------------------------------------------------------------------------------------
Sprout Capital IX, L.P.                                          Sprout Capital IX, L.P.                           $15,460,827.00
                                                                 c/o Sprout Group
                                                                 11 Madison Avenue
                                                                 13th Floor
                                                                 New York, New York  10010
                                                                 Fax:  (212) 538-8245
------------------------------------------------------------------------------------------------------------------------------------
Investor Growth Capital Limited                                  Investor Growth Capital Limited                   $ 8,610,000.00
                                                                 National Westminster House
                                                                 Le Truchot, St. Peter Port
                                                                 Guernsey GY1 4PW
                                                                 Channel Islands
                                                                 Fax:  (441) 481-732-616
------------------------------------------------------------------------------------------------------------------------------------
Investor Group L.P.                                              Investor Group L.P.                               $ 3,690,000.00
                                                                 National Westminster House
                                                                 Le Truchot, St. Peter Port
                                                                 Guernsey GY1 4PW
                                                                 Channel Islands
                                                                 Fax:  (441) 481-732-616
------------------------------------------------------------------------------------------------------------------------------------
Dionis Trust                                                     Dionis Trust                                      $   650,000.00
                                                                 c/o Gund Investment Corporation
                                                                 14 Nassau Street
                                                                 Princeton, NJ  08542
                                                                 Attention:  Mr. Theodore Baker
                                                                 Fax:  (609) 921-7697
------------------------------------------------------------------------------------------------------------------------------------
Grant Gund 1978 Trust                                            Grant Gund 1978 Trust                             $   325,000.00
                                                                 c/o Gund Investment Corporation
                                                                 14 Nassau Street
                                                                 Princeton, NJ  08542
                                                                 Attention:  Mr. Theodore Baker
                                                                 Fax:  (609) 921-7697
------------------------------------------------------------------------------------------------------------------------------------
G. Zachary Gund 1978 Trust                                       G. Zachary Gund 1978 Trust                        $   325,000.00
                                                                 c/o Gund Investment Corporation
                                                                 14 Nassau Street
                                                                 Princeton, NJ  08542
                                                                 Attention:  Mr. Theodore Baker
                                                                 Fax:  (609) 921-7697
------------------------------------------------------------------------------------------------------------------------------------
KBL Healthcare, LP                                               645 Madison Avenue                                $ 1,608,507.00
                                                                 New York, NY  10022
                                                                 Attention:  Marlene Krauss
                                                                 Fax:  (212) 319-5591
------------------------------------------------------------------------------------------------------------------------------------
KBL Partnership, LP                                              645 Madison Avenue                                $   191,493.00
                                                                 New York, NY  10022
                                                                 Attention:  Marlene Krauss
                                                                 Fax:  (212) 319-5591
------------------------------------------------------------------------------------------------------------------------------------
Ontario Teachers' Pension Plan                                   Attn:  Sanderling Venture Partners                $ 3,000,000.00
                                                                 400 S. El Camino Real, Suite 1200
                                                                 San Mateo, CA  94402
                                                                 Attention:  Andrew Lenz
                                                                 Fax: (650) 375-7077
------------------------------------------------------------------------------------------------------------------------------------
CDP Capital                                                      Attn:  Sanderling Venture Partners                $ 2,000,000.00
                                                                 400 S. El Camino Real, Suite 1200
                                                                 San Mateo, CA  94402
                                                                 Attention:  Andrew Lenz
                                                                 Fax: (650) 375-7077
------------------------------------------------------------------------------------------------------------------------------------
TOTAL                                                                                                              $40,000,000
------------------------------------------------------------------------------------------------------------------------------------
</TABLE>

<PAGE>

                                    EXHIBIT B

                                 FORM OF WARRANT

<PAGE>

                                    EXHIBIT C

                           OPINION OF COMPANY COUNSEL

<PAGE>

                                    EXHIBIT D

                AMENDED AND RESTATED CERTIFICATE OF INCORPORATION

<PAGE>

                                    EXHIBIT E

                        FORM OF INDEMNIFICATION AGREEMENT

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