Document:

Exhibit
      10.1

    ZIOPHARM
      Oncology, Inc.

    

    Amendment
      No. 1 to

    2003
      Stock Option Plan

    

    This
      Amendment No. 1 to 2003 Stock Option Plan (the “Amendment”)
      dated
      as of April 26, 2006, amends the 2003 Stock Option Plan (the “2003 Plan”)
      of
      ZIOPHARM Oncology, Inc. (the “Company”).
      Except as otherwise explicitly set forth herein, all provisions of the 2003
      Plan
      shall remain in full force and effect. Capitalized terms used in this Amendment
      without definition shall have the meanings set forth in the 2003 Plan.

    

    WHEREAS,
      the
      2003 Plan was adopted by the Company pursuant to resolutions of the Board of
      Directors of ZIOPHARM, Inc., the Company’s predecessor, as of December 30, 2003
      and approved by ZIOPHARM, Inc.’s stockholders as of December 21,
      2004;

    

    WHEREAS,
      pursuant to a merger transaction that became effective in September 2005, a
      wholly owned subsidiary of the Company merged with and into ZIOPHARM, Inc.,
      with
      ZIOPHARM, Inc. remaining as the surviving entity and a wholly owned operating
      subsidiary of the Company, after which ZIOPHARM, Inc. merged with and into
      the
      Company, with the Company remaining as the surviving corporation (such merger
      transactions are collectively referred to as the “Merger”);

    

    WHEREAS,
      immediately prior to the Merger, the number of shares of ZIOPHARM, Inc. common
      stock available for issuance under the 2003 Plan was 2,500,000;

    

    WHEREAS,
      upon
      the Merger, the Company assumed the 2003 Plan and, as a result of the conversion
      ratio applicable to the Merger, the number of shares of the Company’s common
      stock available for issuance under the 2003 Plan immediately following the
      Merger was 1,252,436; 

    

    WHEREAS,
      an
      amendment to the 2003 Plan increasing the number of shares of the Company’s
      common stock available for issuance thereunder to 2,002,436 was adopted by
      the
      Company pursuant to resolutions of the Board of Directors on February 22, 2006
      and approved by the Company’s stockholders at a meeting of the stockholders held
      on April 26 2006; and 

    

    WHEREAS,
      pursuant to Section 10.11 of the 2003 Plan, the 2003 Plan may be amended upon
      approval of the Board of Directors of the Company, and pursuant to resolutions
      adopted by the Board of Directors on February 22, 2006, the Company has
      determined that it is in the best interests of the Company to amend the Plan
      as
      hereinafter provided.

    

    NOW,
      THEREFORE,
      the
      Plan is hereby amended as follows:

    

    1. Increase
      in Number of Shares Subject to the Plan.
      Section
      5.1 of the Plan is hereby amended in its entirety to read as
      follows:

    

    “5.1. Number
      of Shares.
      Subject
      to adjustment as provided in Section 10.6, the number of shares of Common Stock
      which may be issued under the Plan shall not exceed 2,002,436 shares of Common
      Stock. Shares of Common Stock that are issued under the Plan or are subject
      to
      outstanding Incentives will be applied to reduce the maximum number of shares
      of
      Common Stock remaining available for issuance under the Plan.”

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    

    2. Effective
      Date.
      This
      Amendment shall be effective upon the date first written above.

     

    IN
      WITNESS WHEREOF,
      the
      Company has caused this Amendment to be executed by the undersigned officer,
      thereunto duly authorized pursuant to the resolutions of the Board of
      Directors.

     

    
      	 	
              ZIOPHARM
                Oncology, Inc.:

               

               

              
                By: /s/
                  Jonathan Lewis   

                Name: 
                  Jonathan Lewis   

                Title: Chief
                  Executive OfficerSTARVOX
        COMMUNICATIONS, INC.

       

       

      Senior
        Secured Promissory Note

      
         

        
          	$300,000	 	
                  As
                    of April 20,
                    2006

                

        

         

      

      San
        Jose, California

       

      StarVox
        Communications, Inc., a California corporation (the “Company”), for value
        received, hereby promises to pay to U.S. Wireless Data, Inc., with an address
        at
        2121 Avenue of the Stars, Suite 1650, Los Angeles, California 90067, or its
        successors or permitted assigns (the “Holder”), the principal amount of Three
        Hundred Thousand Dollars ($300,000), in lawful money of the United States
        of
        America, with interest thereon to be computed from the date hereof, on the
        unpaid principal balance at the rate and as herein provided.

       

      All
        agreements herein made are expressly limited so that in no event whatsoever,
        whether by reason of advancement of proceeds hereof, acceleration of maturity
        of
        the unpaid balance hereof or otherwise, shall the amount paid or agreed to
        be
        paid to the Holder for the use of the money advanced or to be advanced hereunder
        exceed the maximum rate permitted by law (the “Maximum Rate”). If, for any
        circumstances whatsoever, the fulfillment of any provision of this Note or
        any
        other agreement or instrument now or hereafter evidencing, securing or in
        any
        way relating to the debt evidenced hereby shall involve the payment of interest
        in excess of the Maximum Rate, then, ipso
        facto,
        the
        obligation to pay interest hereunder shall be reduced to the Maximum Rate;
        and
        if for any circumstance whatsoever, the Holder shall ever receive interest,
        the
        amount of which would exceed the amount collectible at the Maximum Rate,
        such
        amount as would be excessive interest shall be applied to the reduction of
        the
        principal balance remaining unpaid hereunder and not to the payment of interest.
        This provision shall control every other provision in any and all other
        agreements and instruments existing or hereafter arising between the Company
        and
        the Holder with respect to the debt evidenced hereby.

       

      1. Security.

       

      This
        Note
        and the Company’s obligations hereunder are collateralized by a security
        interest in the
        assets of the Company, pursuant to a Security Agreement, dated as of the
        same
        date of this Note (the “Security Agreement”), by and between the Company and the
        Holder, as secured party. If an Event of Default (as hereinafter defined)
        shall
        have occurred and the principal amount of this Note shall become due and
        payable, the Holder shall be entitled to exercise, in addition to any right,
        power or remedy permitted in law or equity, all its remedies under the Security
        Agreement.

       

      2. Interest;
        Payments.

       

      (a) Principal
        of, and any accrued and unpaid interest on, this Note shall be due and payable
        on demand by the Holder at any time following 120 days from the date of this
        Note.

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

       

      (b) Until
        this Note is paid in full, interest on this Note shall accrue from the date
        hereof at the Applicable Rate (calculated on the basis of a 360-day year
        consisting of twelve 30-day months). For purposes of this Note, the Applicable
        Rate shall mean 10.0%, except in the event that the Company fails to pay
        to the
        Holder any portion of the principal and/or interest due on the Maturity Date
        or
        if an Event of Default shall have occurred in which case the Applicable Rate
        shall thereafter, during the continuance of such failure, be 15%.

       

      (c) If
        the
        Maturity Date would fall on a day that is not a Business Day (as defined
        below),
        the payment due on such Maturity Date will be made on the next succeeding
        Business Day with the same force and effect as if made on the Maturity Date.
        “Business Day” means any day which is not a Saturday or Sunday and is not a day
        on which banking institutions are generally authorized or obligated to close
        in
        the city of New York, New York.

       

      (d) Payment
        of principal and interest on this Note shall be made by wire transfer of
        immediately available funds to an account designated by the Holder or by
        check
        sent to the Holder as the Holder may designate for such purpose from time
        to
        time by written notice to the Company, in such coin or currency of the United
        States of America as at the time of payment shall be legal tender for the
        payment of public and private debts.

       

      (e) The
        obligations to make the payments provided for in this Note are absolute and
        unconditional and not subject to any defense, setoff, counterclaim, rescission,
        recoupment or adjustment whatsoever. The Company hereby expressly waives
        demand
        and presentment for payment, notice of non-payment, notice of dishonor, protest,
        notice of protest and diligence in taking any action to collect any amount
        called for hereunder, and shall be directly and primarily liable for the
        payment
        of all sums owing and to be owing hereon, regardless of and without any notice,
        diligence, act or omission with respect to the collection of any amount called
        for hereunder.

       

      (f) Notwithstanding
        anything to the contrary in this Note, the Security Agreement or any other
        document executed in connection herewith, the amounts owing under this Note
        may
        be prepaid at any time without penalty or premium.

       

      3. Ranking
        of Note.

       

      (a) The
        Company, for itself, its successors and assigns, covenants and agrees, that
        the
        payment of the principal of and interest on this Note is senior in right
        of
        payment to the payment of all existing and future Junior Debt (as hereinafter
        defined). “Junior Debt” shall mean all existing and future Indebtedness. For
        purposes of this Section 3(a), “Indebtedness” shall mean, except for Permitted
        Indebtedness (a) all indebtedness for borrowed money or the deferred purchase
        price of property or services, including without limitation reimbursement
        and
        other obligations with respect to surety bonds and letters of credit, (b)
        all
        obligations evidenced by notes, bonds, debentures or similar instruments,
        (c)
        all capital lease obligations and (d) any obligation directly or indirectly
        guaranteed. For purposes of this Section 3(a), “Permitted Indebtedness” shall
        mean the following: (i) Indebtedness to trade creditors incurred in the ordinary
        course of business; (ii) Indebtedness outstanding on the date hereof and
        reflected on the Company’s financial statements delivered to the Holder; (iii)
        Indebtedness permitted by the prior written consent of the Holder; (iv)
        Indebtedness pursuant to capital lease obligations or third party equipment
        financing, provided that such Indebtedness does not exceed the lesser of
        the
        cost or fair market value of the equipment financed with such Indebtedness;
        (v)
        Indebtedness incurred in the ordinary course of business with corporate credit
        cards and merchant services; (vi) Indebtedness of the Company to any wholly
        owned subsidiary; (vii) contingent obligations incurred in connection with
        letters of credit issued for the Company’s account in the ordinary course of
        business, including relating to leases of real estate for the Company’s
        facilities; (viii) Indebtedness arising under currency agreements, interest
        rate
        agreements, hedging agreements or other similar agreements entered into in
        the
        ordinary course of the Company’s business; (ix) Indebtedness owing to Sand Hill
        Finance, LLC; (x) future senior Indebtedness incurred by the Company from
        financial institutions and/or venture debt lenders with the written consent
        of
        Holder, which consent will not be unreasonably withheld or delayed; and (xi)
        extensions, refinancings and renewals of any items of Permitted Indebtedness,
        provided that the principal amount is not increased or the terms modified
        to
        impose more burdensome terms upon the Company. Holder agrees to subordinate
        the
        debt hereunder and liens securing such debt to the debt owing by the Company
        to
        Sand Hill Finance, LLC and liens securing such debt, on such terms as Sand
        Hill
        may reasonably require.

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

       

      (b) Upon
        any
        payment or distribution of the assets of the Company, to creditors upon
        dissolution, total or partial liquidation or reorganization of, or similar
        proceeding relating to the Company, the Holder of this Note will be entitled
        to
        receive payment in full before any holder of Junior Debt is entitled to receive
        any payment.

       

      4. Affirmative
        Covenants.

       

      The
        Company covenants and agrees with the Holder that, so long as any amount
        remains
        unpaid on this Note:

       

      (a) the
        Company shall promptly after the Company shall obtain knowledge of the
        occurrence of any Event of Default (as hereinafter defined) or any event
        which
        with notice or lapse of time or both would become an Event of Default (an
        Event
        of Default or such other event being a “Default”), a notice specifying that such
        notice is a “Notice of Default” and describing such Default in reasonable
        detail, and, in such Notice of Default or as soon thereafter as practicable,
        a
        description of the action the Company has taken or proposes to take with
        respect
        thereto; and

       

      (b) the
        Company shall permit any representative Holder authorizes, including its
        attorneys, accountants, to inspect, examine and make copies and abstracts
        of the
        books of account and records of the Company at reasonable times and upon
        reasonable notice during normal business hours. In addition, any such
        representative shall have the right to meet with management and officers
        of the
        Company to discuss such books of account and records. In addition, Holder
        shall
        be entitled at reasonable times and intervals to consult with and advise
        the
        management and officers of the Company concerning significant business issues
        affecting the Company. Such consultations shall not unreasonably interfere
        with
        the Company's business operations.

       

      5. Events
        of Default.

       

      The
        occurrence of any of the following events shall constitute an event of default
        (an “Event of Default”):

       

      (a) A
        default
        in the payment of the principal or interest on the Note, when and as the
        same
        shall become due and payable, which default is not cured within three (3)
        days
        after written notice thereof.

       

      (b) A
        default
        in the performance, or a breach, of any of the covenants or agreements of
        the
        Company contained in this Note or the Security Agreement, which default (except
        as provided in Section 5(a)) is not cured within ten (10) days after written
        notice thereof.

       

      (c) Any
        representation, warranty or certification made by the Company in or pursuant
        to
        this Note or the Security Agreement is untrue when made.

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

       

      (d) A
        final
        judgment or judgments for the payment of money in excess of $50,000 in the
        aggregate shall be rendered by one or more courts, administrative or arbitral
        tribunals or other bodies having jurisdiction against the Company and the
        same
        shall not be discharged (or provision shall not be made for such discharge),
        or
        a stay of execution thereof shall not be procured, within 60 days from the
        date
        of entry thereof and the Company shall not, within such 60-day period, or
        such
        longer period during which execution of the same shall have been stayed,
        appeal
        therefrom and cause the execution thereof to be stayed during such
        appeal.

       

      (e) The
        entry
        of a decree or order by a court having jurisdiction adjudging the Company
        a
        bankrupt or insolvent, or approving a petition seeking reorganization,
        arrangement, adjustment or composition of or in respect of the Company, under
        federal bankruptcy law, as now or hereafter constituted, or any other applicable
        federal or state bankruptcy, insolvency or other similar law, and the
        continuance of any such decree or order unstayed and in effect for a period
        of
        60 days; or the commencement by the Company of a voluntary case under federal
        bankruptcy law, as now or hereafter constituted, or any other applicable
        federal
        or state bankruptcy, insolvency, or other similar law, or the consent by
        the
        Company to the institution of bankruptcy or insolvency proceedings against
        it,
        or the filing by the Company of a petition or answer or consent seeking
        reorganization or relief under federal bankruptcy law or any other applicable
        federal or state law, or the consent by the Company to the filing of such
        petition or to the appointment of a receiver, liquidator, assignee, trustee,
        sequestrator or similar official of the Company or of any substantial part
        of
        the property of the Company, or the making by the Company of an assignment
        for
        the benefit of creditors, or the admission by the Company in writing of its
        inability to pay its debts generally as they become due, or the taking of
        corporate action by the Company in furtherance of any such action.

       

      6. Remedies
        Upon Default.

       

      Upon
        the
        occurrence of an Event of Default referred to in Sections 5(a) through (e),
        the
        Holder, by notice in writing given to the Company, may declare the entire
        principal amount then outstanding of, and the accrued interest on, this Note
        to
        be due and payable immediately, and upon any such declaration the same shall
        become and be due and payable immediately, without presentation, demand,
        protest
        or other formalities of any kind, all of which are expressly waived by the
        Company. The Holder may institute such actions or proceedings in law or equity
        as it shall deem expedient for the protection of its rights and may prosecute
        and enforce its claims against all assets of the Company, and in connection
        with
        any such action or proceeding shall be entitled to receive from the Company
        payment of the principal amount of this Note plus accrued interest to the
        date
        of payment plus reasonable expenses of collection, including, without
        limitation, reasonable attorneys’ fees and expenses actually
        incurred.

       

      7. Representations
        and Warranties of the Company.
        The
        representations and warranties of the Company set forth in the Security
        Agreement are incorporated herein by reference.

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

      

      8. Miscellaneous.

       

      (a) The
        terms
        and conditions of this Note shall inure to the benefit of and be binding
        upon
        the respective successors and assigns of the parties; provided, however,
        that
        neither party may assign any of its rights or obligations hereunder without
        the
        prior written consent of the other, except that the Holder may assign all
        or a
        portion of its rights hereunder to an affiliate of the Holder without such
        consent. Nothing in this Note, expressed or implied, is intended to confer
        upon
        any party other than the parties hereto or their respective successors and
        assigns any rights, remedies, obligations, or liabilities under or by reason
        of
        this Note, except as expressly provided in this Note. 

       

      (b) Any
        notice or other communication required or permitted to be given hereunder
        shall
        be in writing and shall be mailed by certified mail, return receipt requested,
        or by Federal Express, Express Mail or similar overnight delivery or courier
        service or delivered (in person or by telecopy, telex or similar
        telecommunications equipment) against receipt to the party to whom it is
        to be
        given, (i) if to the Company, at its address at 2728 Orchard Parkway, San
        Jose,
        California 95134, Attention: Chief Executive Officer, (ii) if to the Holder,
        at
        its address set forth on the first page hereof, or (iii) in either case,
        to such
        other address as the party shall have furnished in writing in accordance
        with
        the provisions of this Section 8(b). Notice to the estate of any party shall
        be
        sufficient if addressed to the party as provided in this Section 8(b). Any
        notice or other communication given by certified mail shall be deemed given
        at
        the time of certification thereof, except for a notice changing a party’s
        address which shall be deemed given at the time of receipt thereof. Any notice
        given by other means permitted by this Section 8(b) shall be deemed given
        at the
        time of receipt thereof.

       

      (c) Upon
        receipt of evidence satisfactory to the Company, of the loss, theft, destruction
        or mutilation of this Note (and upon surrender of this Note if mutilated),
        including an affidavit of the Holder thereof that this Note has been lost,
        stolen, destroyed or mutilated together with an indemnity against any claim
        that
        may be made against the Company on account of such lost, stolen, destroyed
        or
        mutilated Note, and upon reimbursement of the Company’s reasonable incidental
        expenses, the Company shall execute and deliver to the Holder a new Note
        of like
        date, tenor and denomination.

       

      (d) No
        course
        of dealing and no delay or omission on the part of the Holder or the Company
        in
        exercising any right or remedy shall operate as a waiver thereof or otherwise
        prejudice the Holder’s or the Company’s rights, powers or remedies, as the case
        may be. No right, power or remedy conferred by this Note upon the Holder
        or the
        Company shall be exclusive of any other right, power or remedy referred to
        herein or now or hereafter available at law, in equity, by statute or otherwise,
        and all such remedies may be exercised singly or concurrently.

       

      (e) If
        one or
        more provisions of this Note are held to be unenforceable under applicable
        law,
        such provision shall be excluded from this Note and the balance of this Note
        shall be interpreted as if such provision were so excluded and shall be
        enforceable in accordance with its terms. This Note may be amended only by
        a
        written instrument executed by the Company and the Holder hereof. Any amendment
        shall be endorsed upon this Note, and all future Holders shall be bound
        thereby.

      
        
          
          

        

        
          
          

          
            

          

        

        
          
          

        

      

       

      (f) This
        Note
        shall be governed by and construed in accordance with the laws of the State
        of
        California, without giving effect to principles governing conflicts of
        law.

       

      (g) Company
        promises to pay any and all reasonable attorneys' and other out of pocket
        professionals' fees and expenses incurred by Holder after the date hereof
        in
        connection with or related to: (i) this Note or the Security Agreement;
        (ii) the collection or enforcement of this Note; (iii) the amendment
        or modification of this Note or the Security Agreement; (iv) any waiver,
        consent, release, or termination under this Note or the Security Agreement;
        (v) the protection, preservation, sale, lease, liquidation, or disposition
        of collateral under the Security Agreement or the exercise of remedies with
        respect to such collateral; (vi) any legal, litigation, administrative,
        arbitration, or out of court proceeding in connection with or related to
        Company
        or the collateral under the Security Agreement, and any appeal or review
        thereof; and (vii) any bankruptcy, restructuring, reorganization,
        assignment for the benefit of creditors, workout, foreclosure, or other action
        related to Company, this Note or the Security Agreement, including representing
        Holder in any adversary proceeding or contested matter commenced or continued
        by
        or on behalf of Company's estate, and any appeal or review thereof. Holder's
        professional fees and expenses shall include out of pocket fees or expenses
        for
        Holder's attorneys, accountants, auctioneers, liquidators, appraisers,
        investment advisors, environmental and management consultants, or experts
        engaged by Holder in connection with the foregoing. Company's promise to
        pay all
        of Holder's professional fees and expenses is part of the obligations under
        this
        Note. All of the foregoing costs and expenses shall be payable within thirty
        (30) days of written demand by Holder. Company agrees that Holder’s written
        demand need not consist of more detail than a separate line item for each
        general category of expense and corresponding amount, such as legal fees
        and
        costs $100.00, filing fees $100.00, or courier services $100.00, etc., provided
        that reasonable detail will be provided upon request by the
        Company.

       

      *     *     *     *     *

       

      
        
           

        

        
           

          
            

          

        

        
           

        

      

       

      IN
        WITNESS WHEREOF,
        the
        Company has caused this Note to be executed and dated the day and year first
        above written.

       

      
        	 	 	 
	 	STARVOX
                COMMUNICATIONS, INC.
	 
 	 
 	 
 
	 	By:  	/s/
                Douglas S. Zorn
	 	
                
                  
Douglas
                  S. Zorn, President and CEO

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