Document:

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                                                                    EXHIBIT 10.2

                               AMICUS THERAPEUTICS

                           2006 EQUITY INCENTIVE PLAN

1.       PURPOSE

         This Plan is intended to encourage ownership of Common Stock by
employees, consultants and directors of the Company and its Affiliates and to
provide additional incentive for them to promote the success of the Company's
business. The Plan is intended to be an incentive stock option plan within the
meaning of Section 422 of the Code but not all Awards granted hereunder are
required to be Incentive Options.

2.       DEFINITIONS

         As used in the Plan the following terms shall have the respective
meanings set out below, unless the context clearly requires otherwise:

         2.1. "Accelerate", "Accelerated", and "Acceleration", when used with
respect to an Option, means that as of the time of reference such Option will
become exercisable with respect to some or all of the shares of Common Stock for
which it was not then otherwise exercisable by its terms, and, when used with
respect to Restricted Stock, means that the Risk of Forfeiture otherwise
applicable to such Common Stock shall expire with respect to some or all of the
shares of Restricted Stock then still otherwise subject to the Risk of
Forfeiture.

         2.2. "Acquiring Person" means, with respect to any Transaction or any
acquisition described in clause (ii) of the definition of Change of Control, the
surviving or acquiring person or entity in connection with such Transaction or
acquisition, as the case may be, provided that if such surviving or acquiring
person or entity is controlled, directly or indirectly, by any other person or
entity (an "Ultimate Parent Entity") that is not itself controlled by any entity
or person that is not a natural person, the term "Acquiring Person" shall mean
such Ultimate Parent Entity.

         2.3. "Affiliate" means, with respect to any person or entity, any other
person or entity controlling, controlled by or under common control with the
first person or entity.

         2.4. "Applicable Voting Control Percentage" means (i) at any time prior
to the initial public offering of the Company, a percentage greater than fifty
percent (50%) and (ii) at any time from and after the initial public offering of
the Company, twenty percent (20%).

         2.5. "Award" means any grant or sale pursuant to the Plan of Options,
Restricted Stock or Stock Grants.

         2.6. "Award Agreement" means an agreement between the Company and the
recipient of an Award, setting forth the terms and conditions of the Award.

         2.7. "Beneficial Ownership" has the meaning ascribed to such term in
Rule 13d-3, or any successor rule thereto, promulgated by the Securities and
Exchange Commission pursuant to the Exchange Act.

         2.8.     "Board" means the Company's board of directors.

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         2.9. "Change of Control" means (i) the closing of any Sale of the
Company Transaction or (ii) the direct or indirect acquisition, in a single
transaction or a series of related transactions, by any person or Group (other
than the Company or a Controlled Affiliate of the Company) of Beneficial
Ownership of previously outstanding shares of capital stock of the Company if
(A) immediately after such acquisition, such person or Group, together with
their respective Affiliates, shall own or hold shares of capital stock of the
Company possessing at least the Applicable Voting Control Percentage of the
total voting power of the outstanding capital stock of the Company, (B)
immediately prior to such acquisition, such person or Group, together with their
respective Affiliates, did not own or hold shares of capital stock of the
Company possessing at least the Applicable Voting Control Percentage of the
total voting power of the outstanding capital stock of the Company, and (C)
within thirty days after the Company is notified or first becomes aware of such
acquisition, whichever is earlier, a majority of the members of the board of
directors of the Company as constituted immediately prior to such acquisition do
not consent in writing to exclude such acquisition from the scope of this
definition.

         2.10. "Code" means the Internal Revenue Code of 1986, as amended from
time to time, or any successor statute thereto, and any regulations issued from
time to time thereunder.

         2.11. "Controlled Affiliate" means, with respect to any person or
entity, any other person or entity that is controlled by such person or entity.

         2.12. "Committee" means any committee of the Board delegated
responsibility by the Board for the administration of the Plan, as provided in
Section 5 of the Plan. For any period during which no such committee is in
existence, "Committee" shall mean the Board and all authority and responsibility
assigned the Committee under the Plan shall be exercised, if at all, by the
Board.

         2.13. "Common Stock" means common stock, par value $0.01 per share, of
the Company.

         2.14. "Company" means Amicus Therapeutics, Inc., a corporation
organized under the laws of the State of Delaware.

         2.15. "Exchange Act" means the Securities Exchange Act of 1934, as
amended.

         2.16. "Grant Date" means the date as of which an Option is granted, as
determined under Section 7.1(a).

         2.17. "Group" has the meaning ascribed to such term in Section 13(d)(3)
of the Exchange Act or any successor section thereto.

         2.18. "Incentive Option" means an Option which by its terms is to be
treated as an "incentive stock option" within the meaning of Section 422 of the
Code.

         2.19. "Market Value" means the value of a share of Common Stock on a
particular date determined by such methods or procedures as may be established
by the Committee. Unless otherwise determined by the Committee, the Market Value
of Common Stock as of any date is the closing price for the Common Stock as
reported on the Nasdaq NMS Quotation System (or on any other national securities
exchange on which the Common Stock is then listed) for that date or, if no
closing price is reported for that date, the closing price on the next preceding
date for which

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a closing price was reported. For purposes of Awards granted as of the effective
date of the Company's initial public offering, Market Value shall be the price
at which the Company's Common Stock is offered to the public in its initial
public offering.

         2.20. "Nonstatutory Option" means any Option that is not an Incentive
Option.

         2.21. "Option" means an option to purchase shares of Common Stock.

         2.22. "Optionee" means a Participant to whom an Option shall have been
initially granted under the Plan.

         2.23. "Participant" means any holder of an outstanding Award under the
Plan.

         2.24. "Plan" means this 2006 Equity Incentive Plan of the Company, as
amended and in effect from time to time.

         2.25. "Restricted Stock" means a grant or sale of shares of Common
Stock to a Participant subject to a Risk of Forfeiture.

         2.26. "Restriction Period" means the period of time, established by the
Committee in connection with an Award of Restricted Stock, during which the
shares of Restricted Stock are subject to a Risk of Forfeiture described in the
applicable Award Agreement.

         2.27. "Risk of Forfeiture" means a limitation on the right of a
Participant to retain an Award of Restricted Stock, including a right in the
Company to reacquire such Restricted Stock at less than their then Market Value,
arising because of the occurrence or non-occurrence of specified events or
conditions.

         2.28. "Sale of the Company Transaction" means any Transaction in which
the stockholders of the Company immediately prior to such Transaction, together
with any and all of such stockholders' Affiliates, do not own or hold,
immediately after consummation of such Transaction, shares of capital stock of
the Acquiring Person in connection with such Transaction possessing at least a
majority of the total voting power of the outstanding capital stock of such
Acquiring Person.

         2.29. "Securities Act" means the Securities Act of 1933, as amended.

         2.30. "Stock Grant" means the grant of shares of Common Stock not
subject to restrictions or other forfeiture conditions.

         2.31. "Ten Percent Owner" means a person who owns, or is deemed within
the meaning of Section 422(b)(6) of the Code to own, stock possessing more than
10% of the total combined voting power of all classes of stock of the Company
(or any parent or subsidiary corporations of the Company, as defined in Section
424(e) and (f), respectively, of the Code). Whether a person is a Ten Percent
Owner shall be determined with respect to each Option based on the facts
existing immediately prior to the Grant Date of such Option.

         2.32. "Transaction" means any merger or consolidation of the Company
with or into another person or entity or the sale or transfer of all or
substantially all of the assets of the Company, in each case in a single
transaction or in a series of related transactions.

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3.       TERM OF THE PLAN

         Unless the Plan shall have been earlier terminated by the Board, Awards
may be granted under this Plan at any time in the period commencing on the
effective date of approval of the Plan by the Board and ending immediately prior
to the tenth anniversary of the earlier of the adoption of the Plan by the Board
or approval of the Plan by the Company's stockholders. Awards granted pursuant
to the Plan within such period shall not expire solely by reason of the
termination of the Plan. Awards of Incentive Options granted prior to
stockholder approval of the Plan are hereby expressly conditioned upon such
approval, but in the event of the failure of the stockholders to approve the
Plan shall thereafter and for all purposes be deemed to constitute Nonstatutory
Options.

4.       STOCK SUBJECT TO THE PLAN

         Subject to the provisions of Section 8 of the Plan, at no time shall
the number of shares of Common Stock issued pursuant to or subject to
outstanding Awards granted under the Plan (including, without limitation,
pursuant to Incentive Options), nor the number of shares of Common Stock issued
pursuant to Incentive Options, exceed the sum of (a)_______ (________)(1) shares
of Common Stock plus (b) an annual increase to be added on the first day of each
of the Company's future fiscal years equal to the lesser of (i) 1,000,000 shares
of Common Stock or (ii) three percent (3%) of the Company's outstanding equity
on a fully diluted basis immediately after the closing of the IPO. For purposes
of applying the foregoing limitation, (x) if any Option expires, terminates, or
is cancelled for any reason without having been exercised in full, or if any
Award of Restricted Stock is forfeited, the shares not purchased by the
Participant or forfeited by the Participant shall again be available for Awards
thereafter to be granted under the Plan, and (y) if any Option is exercised by
delivering previously owned shares in payment of the exercise price therefor,
only the net number of shares, that is, the number of shares issued minus the
number received by the Company in payment of the exercise price, shall be
considered to have been issued pursuant to an Award granted under the Plan.
Shares of Common Stock issued pursuant to the Plan may be either authorized but
unissued shares or shares held by the Company in its treasury.

5.       ADMINISTRATION

         The Plan shall be administered by the Committee; provided, however,
that at any time and on any one or more occasions the Board may itself exercise
any of the powers and responsibilities assigned the Committee under the Plan and
when so acting shall have the benefit of all of the provisions of the Plan
pertaining to the Committee's exercise of its authorities hereunder; and
provided further that the Committee may delegate to an executive officer or
officers the authority to grant Awards hereunder to employees who are not
officers, and to consultants, in accordance with such guidelines as the
Committee shall set forth at any time or from time to time. Subject to the
provisions of the Plan, the Committee shall have complete authority, in its
discretion, to make or to select the manner of making all determinations with
respect to each Award to be granted by the Company under the Plan in addition to
any other determination allowed the Committee under the Plan including, without
limitation: (a) the employee, consultant or director to receive the Award; (b)
the form of Award; (c) whether an Option (if granted to an employee) will be an
Incentive Option or a Nonstatutory Option; (d) the

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(1) This number will represent 5% of the Company on a fully diluted basis
immediately after the closing of the IPO.

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time of granting an Award; (e) the number of shares subject to an Award; (f) the
exercise price of an Option or purchase price for shares of Restricted Stock or
for a Stock Grant and the method of payment of such exercise price or such
purchase price; (g) the term of an Option; (h) the vesting period of shares of
Restricted Stock and any acceleration thereof; (i) the exercise date or dates of
an Option and any acceleration thereof; and (j) the effect of termination of any
employment, consulting or Board member relationship with the Company or any of
its Affiliates on the subsequent exercisability of an Option or on the Risk of
Forfeiture of Restricted Stock. In making such determinations, the Committee may
take into account the nature of the services rendered by the respective
employees, consultants and directors, their present and potential contributions
to the success of the Company and its Affiliates, and such other factors as the
Committee in its discretion shall deem relevant. Subject to the provisions of
the Plan, the Committee shall also have complete authority to interpret the
Plan, to prescribe, amend and rescind rules and regulations relating to it, to
determine the terms and provisions of the respective Award Agreements (which
need not be identical), and to make all other determinations necessary or
advisable for the administration of the Plan. The Committee's determinations
made in good faith on matters referred to in this Plan shall be final, binding
and conclusive on all persons having or claiming any interest under the Plan or
an Award made pursuant hereto.

6.       AUTHORIZATION AND ELIGIBILITY

         The Committee may grant from time to time and at any time prior to the
termination of the Plan one or more Awards, either alone or in combination with
any other Awards, to any employee of or consultant to one or more of the Company
and its Affiliates or to any non-employee member of the Board or of any board of
directors (or similar governing authority) of any Affiliate. However, only
employees of the Company, and of any parent or subsidiary corporations of the
Company, as defined in Sections 424(e) and (f), respectively, of the Code, shall
be eligible for the grant of an Incentive Option. Further, in no event shall the
number of shares of Common Stock covered by Options or other Awards granted to
any one person in any one calendar year (or portion of a year) ending after such
date exceed fifty percent (50%) of the aggregate number of shares of Common
Stock subject to the Plan.

         Each grant of an Award shall be subject to all applicable terms and
conditions of the Plan (including but not limited to any specific terms and
conditions applicable to that type of Award set out in the following Section),
and such other terms and conditions, not inconsistent with the terms of the
Plan, as the Committee may prescribe. No prospective Participant shall have any
rights with respect to an Award, unless and until such Participant has executed
an agreement evidencing the Award, delivered a fully executed copy thereof to
the Company, and otherwise complied with the applicable terms and conditions of
such Award.

7.       SPECIFIC TERMS OF AWARDS

         7.1.   Options.

                  (a) Date of Grant. The granting of an Option shall take place
at the time specified in the Award Agreement. Only if expressly so provided in
the applicable Award Agreement shall the Grant Date be the date on which the
Award Agreement shall have been duly executed and delivered by the Company and
the Optionee.

                  (b) Exercise Price. The price at which shares of Common Stock
may be acquired under each Incentive Option shall be not less than 100% of the
Market Value of

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Common Stock on the Grant Date, or not less than 110% of the Market Value of
Common Stock on the Grant Date if the Optionee is a Ten Percent Owner. The price
at which shares may be acquired under each Nonstatutory Option shall not be so
limited solely by reason of this Section.

                  (c) Option Period. No Incentive Option may be exercised on or
after the tenth anniversary of the Grant Date, or on or after the fifth
anniversary of the Grant Date if the Optionee is a Ten Percent Owner. The Option
period under each Nonstatutory Option shall not be so limited solely by reason
of this Section.

                  (d) Exercisability. An Option may be immediately exercisable
or become exercisable in such installments, cumulative or non-cumulative, as the
Committee may determine. In the case of an Option not otherwise immediately
exercisable in full, the Committee may Accelerate such Option in whole or in
part at any time; provided, however, that in the case of an Incentive Option,
any such Acceleration of such Incentive Option would not cause such Incentive
Option to fail to comply with the provisions of Section 422 of the Code or the
Optionee consents to such Acceleration.

                  (e) Effect of Termination of Employment, Consulting or Board
Member Relationship. Unless the Committee shall provide otherwise with respect
to any Option, if the Optionee's employment, consulting or Board member
relationship with the Company and its Affiliates ends for any reason, including
because an entity with which the Optionee has an employment, consulting or Board
member relationship ceases to be an Affiliate of the Company, any outstanding
Option held by a Participant shall cease to be exercisable in any respect not
later than ninety (90) days following that event and, for the period it remains
exercisable following that event, shall be exercisable only to the extent
exercisable at the date of that event. Military or sick leave or other bona fide
leave shall not be deemed a termination of employment, provided that it does not
exceed the longer of ninety (90) days or the period during which the absent
Optionee's reemployment rights, if any, are guaranteed by statute or by
contract.

                  (f) Transferability. Except as otherwise provided in this
subsection (f), Options shall not be transferable, and no Option or interest
therein may be sold, transferred, pledged, assigned, or otherwise alienated or
hypothecated, other than by will or by the laws of descent and distribution.
Except as otherwise provided in this subsection (f), all of a Participant's
rights in any Option may be exercised during the life of the Participant only by
the Participant or the Participant's legal representative. However, the
Committee may, at or after the grant of a Nonstatutory Option, provide that such
Option may be transferred by the recipient to a family member; provided,
however, that any such transfer is without payment of any consideration
whatsoever and that no transfer of an Option shall be valid unless first
approved by the Committee, acting in its sole discretion. For this purpose,
"family member" means any child, stepchild, grandchild, parent, stepparent,
spouse, former spouse, sibling, niece, nephew, mother-in-law, father-in-law,
son-in-law, daughter-in-law, brother-in-law, or sister-in-law, including
adoptive relationships, any person sharing the Optionee's household (other than
a tenant or employee), a trust in which the foregoing persons have more than
fifty (50) percent of the beneficial interests, a foundation in which the
foregoing persons (or the Optionee) control the management of assets, and any
other entity in which these persons (or the Optionee) own more than fifty (50)
percent of the voting interests.

                  (g) Method of Exercise. An Option may be exercised by a
Participant giving written notice, in the manner provided in Section 15,
specifying the number of shares of Common Stock with respect to which the Option
is then being exercised. The notice shall be accompanied

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by payment in the form of cash or check payable to the order of the Company in
an amount equal to the exercise price of the shares of Common Stock to be
purchased or, subject in each instance to the Committee's approval, acting in
its sole discretion and subject to such conditions, if any, as the Committee may
deem necessary to comply with applicable laws, rules and regulations or to avoid
adverse accounting effects to the Company, by delivery to the Company of (i)
shares of Common Stock having a Market Value equal to the exercise price of the
shares to be purchased, or (ii) the Participant's executed promissory note in
the principal amount equal to the exercise price of the shares to be purchased
and otherwise in such form as the Committee shall have approved. If the Stock is
traded on an established market, payment of any exercise price may also be made
through and under the terms and conditions of any formal cashless exercise
program authorized by the Company entailing the sale of the Stock subject to any
Option in a brokered transaction (other than to the Company). Receipt by the
Company of such notice and payment in any authorized or combination of
authorized means shall constitute the exercise of the Option. Within thirty (30)
days thereafter but subject to the remaining provisions of the Plan, the Company
shall deliver or cause to be delivered to the Participant or his agent a
certificate or certificates for the number of shares then being purchased. Such
shares shall be fully paid and nonassessable. Notwithstanding any of the
foregoing provisions in this subsection (g) to the contrary, (A) no Option shall
be considered to have been exercised unless and until all of the provisions
governing such exercise specified in the Plan and in the relevant Award
Agreement shall have been duly complied with; and (B) the obligation of the
Company to issue any shares upon exercise of an Option is subject to the
provisions of Section 9.1 hereof and to compliance by the Optionee and the
Participant with all of the provisions of the Plan and the relevant Award
Agreement.

                  (h) Limit on Incentive Option Characterization. An Incentive
Option shall be considered to be an Incentive Option only to the extent that the
number of shares of Common Stock for which the Option first becomes exercisable
in a calendar year do not have an aggregate Market Value (as of the date of the
grant of the Option) in excess of the "current limit". The current limit for any
Optionee for any calendar year shall be $100,000 minus the aggregate Market
Value at the date of grant of the number of shares of Common Stock available for
purchase for the first time in the same year under each other Incentive Option
previously granted to the Optionee under the Plan, and under each other
incentive stock option previously granted to the Optionee under any other
incentive stock option plan of the Company and its Affiliates, after December
31, 1986. Any shares of Common Stock which would cause the foregoing limit to be
violated shall be deemed to have been granted under a separate Nonstatutory
Option, otherwise identical in its terms to those of the Incentive Option.

                  (i) Notification of Disposition. Each person exercising any
Incentive Option granted under the Plan shall be deemed to have covenanted with
the Company to report to the Company any disposition of such shares prior to the
expiration of the holding periods specified by Section 422(a)(1) of the Code
and, if and to the extent that the realization of income in such a disposition
imposes upon the Company federal, state, local or other withholding tax
requirements, or any such withholding is required to secure for the Company an
otherwise available tax deduction, to remit to the Company an amount in cash
sufficient to satisfy those requirements.

                  (j) Rights Pending Exercise. No person holding an Option shall
be deemed for any purpose to be a stockholder of the Company with respect to any
of the shares of Common Stock issuable pursuant to his Option, except to the
extent that the Option shall have been exercised with respect thereto and, in
addition, a certificate shall have been issued therefor and delivered to such
holder or his agent.
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         7.2.   Restricted Stock.

                  (a) Purchase Price. Shares of Restricted Stock shall be issued
under the Plan for such consideration, in cash, other property or services, or
any combination thereof, as is determined by the Committee.

                  (b) Issuance of Certificates. Subject to subsection (c) below,
each Participant receiving an Award of Restricted Stock shall be issued a stock
certificate in respect of such shares of Restricted Stock. Such certificate
shall be registered in the name of such Participant, and, if applicable, shall
bear an appropriate legend referring to the terms, conditions, and restrictions
applicable to such Award substantially in the following form:

                  The transferability of this certificate and the shares
                  represented by this certificate are subject to the terms and
                  conditions of the Amicus Therapeutics, Inc. 2006 Equity
                  Incentive Plan and an Award Agreement entered into by the
                  registered owner and Amicus Therapeutics, Inc. Copies of such
                  Plan and Agreement are on file in the offices of Amicus
                  Therapeutics, Inc.

                  (c) Escrow of Shares. The Committee may require that the stock
certificates evidencing shares of Restricted Stock be held in custody by a
designated escrow agent (which may but need not be the Company) until the
restrictions thereon shall have lapsed, and that the Participant deliver a stock
power, endorsed in blank, relating to the Common Stock covered by such Award.

                  (d) Restrictions and Restriction Period. During the
Restriction Period applicable to shares of Restricted Stock, such shares shall
be subject to limitations on transferability and a Risk of Forfeiture arising on
the basis of such conditions related to the performance of services, Company or
Affiliate performance or otherwise as the Committee may determine and provide
for in the applicable Award Agreement. Any such Risk of Forfeiture may be waived
or terminated, or the Restriction Period shortened, at any time by the Committee
on such basis as it deems appropriate.

                  (e) Rights Pending Lapse of Risk of Forfeiture or Forfeiture
of Award. Except as otherwise provided in the Plan or the applicable Award
Agreement, at all times prior to lapse of any Risk of Forfeiture applicable to,
or forfeiture of, an Award of Restricted Stock, the Participant shall have all
of the rights of a stockholder of the Company, including the right to vote the
shares of Restricted Stock.

                  (f) Effect of Termination of Employment, Consulting or Board
Member Relationship. Unless otherwise determined by the Committee at or after
grant and subject to the applicable provisions of the Award Agreement, if a
Participant's employment, consulting or Board member relationship with the
Company and its Affiliates ends for any reason during the Restriction Period,
including because an entity with which the Participant has an employment,
consulting or Board member relationship ceases to be an Affiliate of the
Company, all shares of Restricted Stock still subject to Risk of Forfeiture
shall be forfeited or otherwise subject to return to or repurchase by the
Company on the terms specified in the Award Agreement; provided, however, that
military or sick leave or other bona fide leave shall not be deemed a
termination of employment, if it does not exceed the longer of ninety (90) days
or the period during which the absent Participant's reemployment rights, if any,
are guaranteed by statute or by contract.

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                  (g) Lapse of Restrictions. If and when the Restriction Period
expires without a prior forfeiture of the Restricted Stock, the certificates for
such shares shall be delivered to the Participant promptly if not theretofore so
delivered.

                  (h) Transferability. Except as otherwise provided in this
subsection (h), shares of Restricted Stock shall not be transferable, and no
share of Restricted Stock or interest therein may be sold, transferred, pledged,
assigned, or otherwise alienated or hypothecated, other than by will or by the
laws of descent and distribution. The Committee may, at or after the grant of a
share of Restricted Stock, provide that such share of Restricted Stock may be
transferred by the recipient to a family member; provided, however, that any
such transfer is without payment of any consideration whatsoever and that no
transfer of a share of Restricted Stock shall be valid unless first approved by
the Committee, acting in its sole discretion. For this purpose, "family member"
means any child, stepchild, grandchild, parent, stepparent, spouse, former
spouse, sibling, niece, nephew, mother-in-law, father-in-law, son-in-law,
daughter-in-law, brother-in-law, or sister-in-law, including adoptive
relationships, any person sharing the initial recipient's household (other than
a tenant or employee), a trust in which the foregoing persons have more than
fifty (50) percent of the beneficial interests, a foundation in which the
foregoing persons (or the initial recipient) control the management of assets,
and any other entity in which these persons (or the initial recipient) own more
than fifty (50) percent of the voting interests.

         7.3.   Stock Grants.

                  (a) In General. Stock Grants shall be issued for such
consideration, in cash, other property or services, or any combination thereof,
as is determined by the Committee. Without limiting the generality of the
foregoing, Stock Grants may be awarded in such circumstances as the Committee
deems appropriate, including without limitation in recognition of significant
contributions to the success of the Company or its Affiliates or in lieu of
compensation otherwise already due. Stock Grants shall be made without
forfeiture conditions of any kind.

                  (b) Issuance of Certificates. Each Participant receiving a
Stock Grant shall be issued a stock certificate in respect of such Stock Grant.
Such certificate shall be registered in the name of such Participant, and, if
applicable, shall bear an appropriate legend referring to the terms, conditions,
and restrictions applicable to such Award substantially in the following form:

                  The transferability of this certificate and the shares
                  represented by this certificate are subject to the terms and
                  conditions of the Amicus Therapeutics, Inc. 2006 Equity
                  Incentive Plan. A copy of such Plan is on file in the offices
                  of Amicus Therapeutics, Inc.

         7.4. Awards to Participants Outside the United States. The Committee
may modify the terms of any Award under the Plan granted to a Participant who
is, at the time of grant or during the term of the Award, resident or primarily
employed outside of the United States in any manner deemed by the Committee to
be necessary or appropriate in order that such Award shall conform to laws,
regulations, and customs of the country in which the Participant is then
resident or primarily employed, or so that the value and other benefits of the
Award to the Participant, as affected by foreign tax laws and other restrictions
applicable as a result of the Participant's residence or employment abroad,
shall be comparable to the value of such an Award to a Participant who is
resident or primarily employed in the United States. An Award may be modified
under this Section 7.4 in a manner that is inconsistent with the express terms
of the Plan, so long as such modifications will not contravene any applicable
law or regulation. The

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Committee may establish supplements to, or amendments, restatements, or
alternative versions of the Plan for the purpose of granting and administrating
any such modified Award. No such modification, supplement, amendment,
restatement or alternative version may increase the share limit of Section 4.

8.       ADJUSTMENT PROVISIONS

         8.1. Adjustment for Corporate Actions. All of the share numbers set
forth in the Plan reflect the capital structure of the Company as of
_____________ __, 2006 (i.e., prior to a reverse split anticipated to occur in
connection with the initial public offering of the Company's Common Stock).
Subject to the provisions of Section 8.2, if subsequent to such date the
outstanding shares of Common Stock (or any other securities covered by the Plan
by reason of the prior application of this Section) are increased, decreased, or
exchanged for a different number or kind of shares or other securities, or if
additional shares or new or different shares or other securities are distributed
with respect to such shares of Common Stock or other securities, through merger,
consolidation, sale of all or substantially all the property of the Company,
reorganization, recapitalization, reclassification, stock dividend, stock split,
reverse stock split, or other distribution with respect to such shares of Common
Stock, or other securities, an appropriate and proportionate adjustment will be
made in (i) the maximum numbers and kinds of shares provided in Section 4, (ii)
the numbers and kinds of shares or other securities subject to the then
outstanding Awards, (iii) the exercise price for each share or other unit of any
other securities subject to then outstanding Options (without change in the
aggregate purchase price as to which such Options remain exercisable), and (iv)
the repurchase price of each share of Restricted Stock then subject to a Risk of
Forfeiture in the form of a Company repurchase right.

         8.2. Change of Control. Subject to the applicable provisions of the
Award Agreement, in the event of a Change of Control, the Committee shall have
the discretion, exercisable in advance of, at the time of, or (except to the
extent otherwise provided below) at any time after, the Change of Control, to
provide for any or all of the following (subject to and upon such terms as the
Committee may deem appropriate): (A) the Acceleration, in whole or in part, of
any or all outstanding Options (including Options that are assumed or replaced
pursuant to clause (C) below) that are not exercisable in full at the time the
Change of Control, such Acceleration to become effective at the time of the
Change of Control, or at such time following the Change of Control that the
employment, consulting or Board member relationship of the applicable Optionee
or Optionees with the Company and its Affiliates terminates, or at such other
time or times as the Committee shall determine; (B) the termination of any or
all of the Company's repurchase rights with respect to Restricted Stock Awards,
such termination to become effective at the time of the Change of Control, or at
such time following the Change of Control that the employment, consulting or
Board member relationship with the Company and its Affiliates of the Participant
or Participants that hold such Restricted Stock Awards (or the person to whom
such Restricted Stock Awards were initially granted) terminates, or at such
other time or times as the Committee shall determine; (C) the assumption of
outstanding Options, or the substitution of outstanding Options with equivalent
options, by the acquiring or succeeding corporation or entity (or an affiliate
thereof); or (D) the termination of all Options (other than Options that are
assumed or substituted pursuant to clause (C) above) that remain outstanding at
the time of the consummation of the Change of Control, provided that, the
Committee shall have made the determination to effect such termination prior to
the consummation of the Change of Control and the Committee shall have given, or
caused to be given, to all Participants written notice of such potential
termination at least five business days prior to the consummation of the Change
of Control, and provided, further, that, if the Committee shall have determined
in its sole and

<PAGE>
                                     - 11 -

absolute discretion that the Corporation make payment or provide consideration
to the holders of such terminated Options on account of such termination, which
payment or consideration shall be on such terms and conditions as the Committee
shall have determined (and which could consist of, in the Committee's sole and
absolute discretion, payment to the applicable Optionee or Optionees of an
amount of cash equal to the difference between the Market Value of the shares of
Common Stock for which the Option is then exercisable and the aggregate exercise
price for such shares under the Option), then the Corporation shall be required
to make such payment or provide such consideration in accordance with the terms
and conditions so determined by the Committee; otherwise the Corporation shall
not be required to make any payment or provide any consideration in connection
with, or as a result of, the termination of Options pursuant to the foregoing
provisions of this clause (D). The provisions of this Section 8.2 shall not be
construed as to limit or restrict in any way the Committee's general authority
under Sections 7.1(d) or 7.2(d) hereof to Accelerate Options in whole or in part
at any time or to waive or terminate at any time any Risk of Forfeiture
applicable to shares of Restricted Stock. Each outstanding Option that is
assumed in connection with a Change of Control, or is otherwise to continue in
effect subsequent to a Change of Control, will be appropriately adjusted,
immediately after the Change of Control, as to the number and class of
securities and the price at which it may be exercised in accordance with Section
8.1.

         8.3. Dissolution or Liquidation. Upon dissolution or liquidation of the
Company, each outstanding Option shall terminate, but the Optionee (if at the
time he or she has an employment, consulting or Board member relationship with
the Company or any of its Affiliates) shall have the right, immediately prior to
such dissolution or liquidation, to exercise the Option to the extent
exercisable on the date of such dissolution or liquidation.

         8.4. Related Matters. Any adjustment in Awards made pursuant to this
Section 8 shall be determined and made, if at all, by the Committee and shall
include any correlative modification of terms, including of Option exercise
prices, rates of vesting or exercisability, Risks of Forfeiture and applicable
repurchase prices for Restricted Stock, which the Committee may deem necessary
or appropriate so as to ensure that the rights of the Participants in their
respective Awards are not substantially diminished nor enlarged as a result of
the adjustment and corporate action other than as expressly contemplated in this
Section 8. No fraction of a share shall be purchasable or deliverable upon
exercise, but in the event any adjustment hereunder of the number of shares
covered by an Award shall cause such number to include a fraction of a share,
such number of shares shall be adjusted to the nearest smaller whole number of
shares. No adjustment of an Option exercise price per share pursuant to this
Section 8 shall result in an exercise price which is less than the par value of
the Common Stock.

9.       SETTLEMENT OF AWARDS

         9.1. Violation of Law. Notwithstanding any other provision of the Plan
or the relevant Award Agreement, if, at any time, in the reasonable opinion of
the Company, the issuance of shares of Common Stock covered by an Award may
constitute a violation of law, then the Company may delay such issuance and the
delivery of a certificate for such shares until (i) approval shall have been
obtained from such governmental agencies, other than the Securities and Exchange
Commission, as may be required under any applicable law, rule, or regulation and
(ii) in the case where such issuance would constitute a violation of a law
administered by or a regulation of the Securities and Exchange Commission, one
of the following conditions shall have been satisfied:

<PAGE>
                                     - 12 -

                  (a) the shares are at the time of the issue of such shares
effectively registered under the Securities Act; or

                  (b) the Company shall have determined, on such basis as it
deems appropriate (including an opinion of counsel in form and substance
satisfactory to the Company) that the sale, transfer, assignment, pledge,
encumbrance or other disposition of such shares or such beneficial interest, as
the case may be, does not require registration under the Securities Act or any
applicable state securities laws.

         9.2. Corporate Restrictions on Rights in Stock. Any Common Stock to be
issued pursuant to Awards granted under the Plan shall be subject to all
restrictions upon the transfer thereof which may be now or hereafter imposed by
the Certificate of Incorporation and the By-laws of the Company, each as amended
and in effect from time to time. Whenever Common Stock is to be issued pursuant
to an Award, if the Committee so directs at the time of grant (or, if such Award
is an Option, at any time prior to the exercise thereof), the Company shall be
under no obligation, notwithstanding any other provision of the Plan or the
relevant Award Agreement to the contrary, to issue such shares until such time,
if ever, as the recipient of the Award (and any person who exercises any Option,
in whole or in part), shall have become a party to and bound by any agreement
that the Committee shall require in its sole discretion. In addition, any Common
Stock to be issued pursuant to Awards granted under the Plan shall be subject to
all stop-transfer orders and other restrictions as the Committee may deem
advisable under the rules, regulations and other requirements of any stock
exchange upon which the Common Stock is then listed, and any applicable federal
or state securities laws, and the Committee may cause a legend or legends to be
put on any such certificates to make appropriate reference to such restrictions.

         9.3. Investment Representations. The Company shall be under no
obligation to issue any shares covered by an Award unless the shares to be
issued pursuant to Awards granted under the Plan have been effectively
registered under the Securities Act or the Participant shall have made such
written representations to the Company (upon which the Company believes it may
reasonably rely) as the Company may deem necessary or appropriate for purposes
of confirming that the issuance of such shares will be exempt from the
registration requirements of that Act and any applicable state securities laws
and otherwise in compliance with all applicable laws, rules and regulations,
including but not limited to that the Participant is acquiring shares for his or
her own account for the purpose of investment and not with a view to, or for
sale in connection with, the distribution of any such shares.

         9.4. Registration. If the Company shall deem it necessary or desirable
to register under the Securities Act or other applicable statutes any shares of
Common Stock issued or to be issued pursuant to Awards granted under the Plan,
or to qualify any such shares of Common Stock for exemption from the Securities
Act or other applicable statutes, then the Company shall take such action at its
own expense. The Company may require from each recipient of an Award, or each
holder of shares of Common Stock acquired pursuant to the Plan, such information
in writing for use in any registration statement, prospectus, preliminary
prospectus or offering circular as is reasonably necessary for such purpose and
may require reasonable indemnity to the Company and its officers and directors
from such holder against all losses, claims, damage and liabilities arising from
such use of the information so furnished and caused by any untrue statement of
any material fact therein or caused by the omission to state a material fact
required to be stated therein or necessary to make the statements therein not
misleading in the light of the circumstances under which they were made.

<PAGE>
                                     - 13 -

         9.5. Lock-Up. Without the prior written consent of the Company or the
managing underwriter in any public offering of shares of Common Stock, no
Participant shall sell, make any short sale of, loan, grant any option for the
purchase of, pledge or otherwise encumber, or otherwise dispose of, any shares
of Common Stock during the one hundred-eighty (180) day period commencing on the
effective date of the registration statement relating to any underwritten public
offering of securities of the Company. The foregoing restrictions are intended
and shall be construed so as to preclude any Participant from engaging in any
hedging or other transaction that is designed to or reasonably could be expected
to lead to or result in, a sale or disposition of any shares of Common Stock
during such period even if such shares of Common Stock are or would be disposed
of by someone other than such Participant. Such prohibited hedging or other
transactions would include, without limitation, any short sale (whether or not
against the box) or any purchase, sale or grant of any right (including without
limitation any put or call option) with respect to any shares of Common Stock or
with respect to any security that includes, relates to, or derives any
significant part of its value from any shares of Common Stock. Without limiting
the generality of the foregoing provisions of this Section 9.5, if, in
connection with any underwritten public offering of securities of the Company,
the managing underwriter of such offering requires that the Company's directors
and officers enter into a lock-up agreement containing provisions that are more
restrictive than the provisions set forth in the preceding sentence, then (a)
each Participant (regardless of whether or not such Participant has complied or
complies with the provisions of clause (b) below) shall be bound by, and shall
be deemed to have agreed to, the same lock-up terms as those to which the
Company's directors and officers are required to adhere; and (b) at the request
of the Company or such managing underwriter, each Participant shall execute and
deliver a lock-up agreement in form and substance equivalent to that which is
required to be executed by the Company's directors and officers.

         9.6. Placement of Legends; Stop Orders; Etc. Each share of Common Stock
to be issued pursuant to Awards granted under the Plan may bear a reference to
the investment representations made in accordance with Section 9.3 in addition
to any other applicable restrictions under the Plan, the terms of the Award and,
if applicable, under any agreement between the Company and any Optionee and/or
Participant, and to the fact that no registration statement has been filed with
the Securities and Exchange Commission in respect to such shares of Common
Stock. All certificates for shares of Common Stock or other securities delivered
under the Plan shall be subject to such stock transfer orders and other
restrictions as the Committee may deem advisable under the rules, regulations,
and other requirements of any stock exchange upon which the Common Stock is then
listed, and any applicable federal or state securities law, and the Committee
may cause a legend or legends to be placed on any such certificates to make
appropriate reference to such restrictions.

         9.7. Tax Withholding. Whenever shares of Common Stock are issued or to
be issued pursuant to Awards granted under the Plan, the Company shall have the
right to require the recipient to remit to the Company an amount sufficient to
satisfy federal, state, local or other withholding tax requirements if, when,
and to the extent required by law (whether so required to secure for the Company
an otherwise available tax deduction or otherwise) prior to the delivery of any
certificate or certificates for such shares. The obligations of the Company
under the Plan shall be conditional on satisfaction of all such withholding
obligations and the Company shall, to the extent permitted by law, have the
right to deduct any such taxes from any payment of any kind otherwise due to the
recipient of an Award. However, in such cases Participants may elect, subject to
the approval of the Committee, acting in its sole discretion, to satisfy an
applicable withholding requirement, in whole or in part, by having the Company
withhold shares to satisfy their tax obligations. Participants may only elect to
have Shares withheld having a Market Value

<PAGE>
                                     - 14 -

on the date the tax is to be determined equal to the minimum statutory total tax
which could be imposed on the transaction. All elections shall be irrevocable,
made in writing, signed by the Participant, and shall be subject to any
restrictions or limitations that the Committee deems appropriate.

10.      RESERVATION OF STOCK

         The Company shall at all times during the term of the Plan and any
outstanding Options granted hereunder reserve or otherwise keep available such
number of shares of Common Stock as will be sufficient to satisfy the
requirements of the Plan (if then in effect) and such Options and shall pay all
fees and expenses necessarily incurred by the Company in connection therewith.

11.      NO SPECIAL SERVICE RIGHTS

         Nothing contained in the Plan or in any Award Agreement shall confer
upon any recipient of an Award any right with respect to the continuation of his
or her employment, consulting or Board member relationship with the Company (or
any Affiliate), or interfere in any way with the right of the Company (or any
Affiliate), subject to the terms of any separate employment, consulting or Board
member agreement or provision of law or corporate articles or by-laws to the
contrary, at any time to terminate such employment, consulting or Board member
agreement or to increase or decrease, or otherwise adjust, the other terms and
conditions of the recipient's employment, consulting or Board member
relationship with the Company and its Affiliates.

12.      NONEXCLUSIVITY OF THE PLAN

         Neither the adoption of the Plan by the Board nor the submission of the
Plan to the stockholders of the Company shall be construed as creating any
limitations on the power of the Board to adopt such other incentive arrangements
as it may deem desirable, including without limitation, the granting of stock
options and restricted stock other than under the Plan, and such arrangements
may be either applicable generally or only in specific cases.

13.      TERMINATION AND AMENDMENT OF THE PLAN

         The Board may at any time terminate the Plan or make such amendments or
modifications of the Plan as it shall deem advisable. In the event of the
termination of the Plan, the terms of the Plan shall survive any such
termination with respect to any Award that is outstanding on the date of such
termination, unless the holder of such Award agrees in writing to terminate such
Award or to terminate all or any of the provisions of the Plan that apply to
such Award. Unless the Board otherwise expressly provides, any amendment or
modification of the Plan shall affect the terms of any Award outstanding on the
date of such amendment or modification as well as the terms of any Award made
from and after the date of such amendment or modification; provided, however,
that, except to the extent otherwise provided in the last sentence of this
paragraph, (i) no amendment or modification of the Plan shall apply to any Award
that is outstanding on the date of such amendment or modification if such
amendment or modification would reduce the number of shares subject to such
Award, increase the purchase price applicable to shares subject to such Award or
materially adversely affect the provisions applicable to such Award that relate
to the vesting or exercisability of such Award or of the shares subject to such
Award, (ii) no amendment or modification of the Plan shall apply to any
Incentive Option that is outstanding on the date of such amendment or
modification if such

<PAGE>
                                     - 15 -

amendment or modification would result in such Incentive Option no longer being
treated as an "incentive stock option" within the meaning of Section 422 of the
Code and (iii) no amendment or modification of the Plan shall apply to any Award
that is outstanding on the date of such amendment or modification unless such
amendment or modification of the Plan shall also apply to all other Awards
outstanding on the date of such amendment or modification. In the event of any
amendment or modification of the Plan that is described in clause (i), (ii) or
(iii) of the foregoing proviso, such amendment or modification of the Plan shall
apply to any Award outstanding on the date of such amendment or modification
only if the recipient of such Award consents in writing thereto.

         The Committee may amend or modify, prospectively or retroactively, the
terms of any outstanding Award without amending or modifying the terms of the
Plan itself, provided that as amended or modified such Award is consistent with
the terms of the Plan as in effect at the time of the amendment or modification
of such Award, but no such amendment or modification of such Award shall,
without the written consent of the recipient of such Award, reduce the number of
shares subject to such Award, increase the purchase price applicable to shares
subject to such Award, adversely affect the provisions applicable to such Award
that relate to the vesting or exercisability of such Award or of the shares
subject to such Award, or otherwise materially adversely affect the terms of
such Award (except for amendments or modifications to the terms of such Award or
of the stock subject to such Award that are expressly permitted by the terms of
the Plan or that result from any amendment or modification of the Plan in
accordance with the provisions of the first paragraph of this Section 13), or,
if such Award is an Incentive Option, result in such Incentive Option no longer
being treated as an "incentive stock option" within the meaning of Section 422
of the Code.

         In addition, notwithstanding anything express or implied in any of the
foregoing provisions of this Section 13 to the contrary, the Committee may amend
or modify, prospectively or retroactively, the terms of any outstanding Award to
the extent the Committee reasonably determines necessary or appropriate to
conform such Award to the requirements of Section 409A of the Code (concerning
non-qualified deferred compensation), if applicable.

14.      INTERPRETATION OF THE PLAN

         In the event of any conflict between the provisions of this Plan and
the provisions of any applicable Award Agreement, the provisions of this Plan
shall control, except if and to the extent that the conflicting provision in
such Award Agreement was authorized and approved by the Committee at the time of
the grant of the Award evidenced by such Award Agreement or is ratified by the
Committee at any time subsequent to the grant of such Award, in which case the
conflicting provision in such Award Agreement shall control. Without limiting
the generality of the foregoing provisions of this Section 14, insofar as
possible the provisions of the Plan and such Award Agreement shall be construed
so as to give full force and effect to all such provisions. In the event of any
conflict between the provisions of this Plan and the provisions of any other
agreement between the Company and the Optionee and/or Participant, the
provisions of such agreement shall control except as required to fulfill the
intention that this Plan constitute an incentive stock option plan within the
meaning of Section 422 of the Code, but insofar as possible the provisions of
the Plan and any such agreement shall be construed so as to give full force and
effect to all such provisions.

<PAGE>
                                     - 16 -

15.      NOTICES AND OTHER COMMUNICATIONS

         Any notice, demand, request or other communication hereunder to any
party shall be deemed to be sufficient if contained in a written instrument
delivered in person or duly sent by first class registered, certified or
overnight mail, postage prepaid, or telecopied with a confirmation copy by
regular, certified or overnight mail, addressed or telecopied, as the case may
be, (i) if to the recipient of an Award, at his or her residence address last
filed with the Company and (ii) if to the Company, at its principal place of
business, addressed to the attention of its Chief Executive Officer, or to such
other address or telecopier number, as the case may be, as the addressee may
have designated by notice to the addressor. All such notices, requests, demands
and other communications shall be deemed to have been received: (i) in the case
of personal delivery, on the date of such delivery; (ii) in the case of mailing,
when received by the addressee; and (iii) in the case of facsimile transmission,
when confirmed by facsimile machine report.

16.      GOVERNING LAW

         The Plan and all Award Agreements and actions taken thereunder shall be
governed, interpreted and enforced in accordance with the laws of the State of
Delaware, without regard to the conflict of laws principles thereof.<PAGE>
                                                                    Exhibit 10.3

                             AMICUS THERAPEUTICS, INC.

                        2006 EMPLOYEE STOCK PURCHASE PLAN

      The following constitute the provisions of the 2006 Employee Stock
Purchase Plan of Amicus Therapeutics, Inc.

1.    PURPOSE

      The purpose of the Plan is to provide employees of the Company and its
Designated Subsidiaries with an opportunity to purchase Common Stock of the
Company. It is the intention of the Company to have the Plan qualify as an
"Employee Stock Purchase Plan" under Section 423 of the Code. The provisions of
the Plan shall, accordingly, be construed so as to extend and limit
participation in a manner consistent with the requirements of that section of
the Code.

2.    DEFINITIONS

      2.1.  Board means the Board of Directors of the Company.

      2.2.  Code means the Internal Revenue Code of 1986, as amended.

      2.3.  Common Stock means the common stock, par value $0.001 per share,
of the Company.

      2.4.  Company means Amicus Therapeutics, Inc., a Delaware corporation.

      2.5. Compensation means all regular straight time compensation including
commissions but shall not include payments for overtime, shift premium,
incentive compensation, incentive payments, bonuses and other irregular or
infrequent compensation or benefits.

      2.6. Continuous Status as an Employee means the absence of any
interruption or termination of service as an Employee. Continuous Status as an
Employee shall not be considered interrupted in the case of (i) sick leave; (ii)
military leave; (iii) any other leave of absence approved by the Administrator,
provided that such leave is for a period of not more than 90 days, unless
reemployment upon the expiration of such leave is guaranteed by contract or
statute, or unless provided otherwise pursuant to Company policy adopted from
time to time; or (iv) in the case of transfers between locations of the Company
or between the Company and its Designated Subsidiaries.

      2.7.  Contributions means all amounts credited to the account of a
participant pursuant to the Plan.

      2.8. Corporate Transaction means a merger or consolidation of the Company
with and into another person or the sale, transfer, or other disposition of all
or substantially all of the Company's assets to one or more persons (other than
any wholly-owned subsidiary of the Company) in a single transaction or series of
related transactions.

      2.9. Designated Subsidiaries means the Subsidiaries which have been
designated by the Board from time to time in its sole discretion as eligible to
participate in the Plan.
<PAGE>
                                      -2-

      2.10. Employee means any person, including an Officer, who is customarily
employed for at least twenty (20) hours per week and more than five (5) months
in a calendar year by the Company or one of its Designated Subsidiaries.

      2.11. Exchange Act means the Securities Exchange Act of 1934, as
amended.

      2.12. Offering Commencement Date means the first business day of each
Offering Period of the Plan.

      2.13. Offering Period means any of the periods, generally of six (6)
months duration, as set forth in Section 4.

      2.14. Officer means a person who is an officer of the Company within the
meaning of Section 16 of the Exchange Act and the rules and regulations
promulgated thereunder.

      2.15. Offering Termination Date means the last business day of each
Offering Period of the Plan.

      2.16. Plan means this Employee Stock Purchase Plan.

      2.17. Purchase Price means with respect to an Offering Period an amount
equal to eighty five percent (85%) of the Fair Market Value (as defined in
Section 7.2 below) of a Share on the Offering Commencement Date or on the
Offering Termination Date, whichever is lower; provided, however, that (i) if
there is an increase in the number of Shares available for issuance under the
Plan as a result of a stockholder-approved amendment to the Plan, (ii) all or a
portion of such additional Shares are to be issued with respect to the Offering
Period underway at the time of such increase ("Additional Shares"), and (iii)
the Fair Market Value of a Share of Common Stock on the date of such increase
(the "Approval Date Fair Market Value") is higher than the Fair Market Value on
the Offering Commencement Date for such Offering Period, then in such instance
the Purchase Price with respect to Additional Shares shall be eighty five
percent (85%) of the Approval Date Fair Market Value or the Fair Market Value of
a Share of Common Stock on the Offering Termination Date, whichever is lower.

      2.18. Share means a share of Common Stock, as adjusted in accordance
with Section 18 of the Plan.

      2.19. Subsidiary means a corporation, in an unbroken chain of corporations
beginning with the Company if, at the time of the granting of the option, each
of the corporations other than the last corporation in the unbroken chain owns
stock possessing fifty percent (50%) or more of the total combined voting power
of all classes of stock in one of the other corporations in such chain.

3.    ELIGIBILITY

      3.1. Any person who is an Employee as of the Offering Commencement Date of
a given Offering Period shall be eligible to participate in such Offering Period
under the Plan, subject to the requirements of Sections 5.1 and the limitations
imposed by Section 423(b) of the Code.
<PAGE>
                                      -3-

      3.2. Any provisions of the Plan to the contrary notwithstanding, no
Employee shall be granted an option under the Plan (i) if, immediately after the
grant, such Employee (taking into account stock which would be attributed to
such Employee pursuant to Section 424(d) of the Code) would own capital stock of
the Company and/or hold outstanding options to purchase stock possessing five
percent (5%) or more of the total combined voting power or value of all classes
of stock of the Company or of any Subsidiary of the Company, or (ii) if such
option would permit his or her rights to purchase stock under all employee stock
purchase plans (described in Section 423 of the Code) of the Company and its
Subsidiaries to accrue at a rate which exceeds Twenty-Five Thousand Dollars
($25,000) of the Fair Market Value (as defined in Section 7.2 below) of such
stock (determined at the time such option is granted) for each calendar year in
which such option is outstanding at any time.

4.    OFFERING PERIODS

      Each Offering Period will begin on January 1 or July 1 and end on the next
following June 30 or December 31, respectively, with the first Offering Period
commencing on January 1, 2007. At any time and from time to time, the Board may
change the duration and/or the frequency of Offering Periods with respect to
future Offering Periods or suspend operation of the Plan with respect to
Offering Periods not yet commenced.

5.    PARTICIPATION

      5.1. An eligible Employee may become a participant in the Plan by
completing a subscription agreement on the form provided by the Company and
filing it with the Company's payroll office prior to the applicable Offering
Commencement Date, unless a later time for filing the subscription agreement is
set by the Board for all eligible Employees with respect to a given Offering
Period. The subscription agreement shall set forth the percentage of the
participant's Compensation (subject to Section 6.1 below) to be paid as
Contributions pursuant to the Plan.

      5.2. Payroll deductions shall commence on the first payroll following the
Offering Commencement Date and shall end on the last payroll paid on or prior to
the Offering Termination Date of the Offering Period to which the subscription
agreement is applicable, unless sooner terminated by the participant as provided
in Section 10.

6.    METHOD OF PAYMENT OF CONTRIBUTIONS

      6.1. A participant may elect to have payroll deductions made on each
payday during any Offering Period in an amount not less than one percent (1%)
and not more than fifteen percent (15%) (or such other percentage as the Board
may establish from time to time before an Offering Commencement Date) of such
participant's Compensation on each payday during the Offering Period. All
payroll deductions made by a participant shall be credited to his or her account
under the Plan. A participant may not make any additional payments into such
account.

      6.2. A participant may discontinue his or her participation in the Plan as
provided in Section 10. In addition, if the Board has so announced to Employees
at least five (5) days prior to the scheduled beginning of the next Offering
Period to be affected by the Board's determination, a participant may, on one
occasion only during each Offering Period, change the rate of his or her
Contributions with respect to the Offering Period by completing and filing with
the Company a new subscription agreement authorizing a change in the payroll
deduction rate. If otherwise permitted, no such change shall enable a
participant to resume Contributions other than as of an
<PAGE>
                                      -4-

Offering Commencement Date, following a withdrawal of Contributions during an
Offering Period pursuant to Section 10. Any such change in rate shall be
effective as of the first payroll period following the date of filing of the new
subscription agreement, if the agreement is filed at least ten (10) business
days prior to such period and, if not, as of the second following payroll
period.

      6.3. Notwithstanding the foregoing, to the extent necessary to comply with
Section 423(b)(8) of the Code and Section 3.2 herein, a participant's payroll
deductions may be decreased during any Offering Period scheduled to end during
the current calendar year to zero percent (0%). Payroll deductions reduced to
zero percent (0%) in compliance with this Section 6.3 shall re-commence
automatically at the rate provided in such participant's subscription agreement
at the beginning of the first Offering Period which is scheduled to end in the
following calendar year, unless terminated by the participant as provided in
Section 10.

7.    GRANT OF OPTION

      7.1. On the Offering Commencement Date of each Offering Period, each
eligible Employee participating in such Offering Period shall be granted an
option to purchase on the Offering Termination Date of that Offering Period a
number of Shares determined by dividing such Employee's Contributions
accumulated prior to such Offering Termination Date and retained in the
participant's account as of the Offering Termination Date by the applicable
Purchase Price. However, the maximum number of Shares an Employee may purchase
during each Offering Period shall be ____ Shares(1), and provided further that
such purchase shall be subject to the limitations set forth in Sections 3.2 and
12.

      7.2. The fair market value of the Company's Common Stock on a given date
(the "Fair Market Value") means the value of a share of Common Stock on a
particular date determined by such methods or procedures as may be established
by the Committee. Unless otherwise determined by the Committee, the Fair Market
Value of the Common Stock as of any date (or, in the event that the Common Stock
is not traded on such date, on the immediately preceding trading date), is the
closing price for the Common Stock as reported by the National Association of
Securities Dealers Automated Quotation ("Nasdaq") System (or on any other
national securities exchange on which the Common Stock is then listed) for that
date or, if no closing price is reported for that date, the closing price on the
next preceding date for which a closing price was reported.

8.    EXERCISE OF OPTION

      Unless a participant withdraws from the Plan as provided in Section 10,
his or her option for the purchase of Shares will be exercised automatically on
the Offering Termination Date of an Offering Period, and the maximum number of
full Shares subject to the option will be purchased at the applicable Purchase
Price with the accumulated Contributions in his or her account. No fractional
Shares shall be issued. The Shares purchased upon exercise of an option
hereunder shall be deemed to be transferred to the participant on the Offering
Termination Date. During his or her lifetime, a participant's option to purchase
Shares hereunder is exercisable only by him or her.

----------
(1)   This number will represent two percent (2%) of the total allocable pool
      under the Plan.
<PAGE>
                                      -5-

9.    DELIVERY

      As promptly as practicable after each Offering Termination Date of each
Offering Period, the Company shall arrange the delivery to each participant, as
appropriate, of a certificate representing the Shares purchased upon exercise of
his or her option. Any payroll deductions accumulated in a participant's account
which are not sufficient to purchase a full Share shall be retained in the
participant's account for the subsequent Offering Period, subject to earlier
withdrawal by the participant as provided in Section 10 below. Any other amounts
left over in a participant's account after an Offering Termination Date shall be
returned to the participant.

10.   VOLUNTARY WITHDRAWAL; TERMINATION OF EMPLOYMENT

      10.1. A participant may withdraw all but not less than all of the
Contributions credited to his or her account under the Plan at any time prior to
each Offering Termination Date by giving written notice to the Company. All of
the participant's Contributions credited to his or her account will be paid to
him or her promptly after receipt of his or her notice of withdrawal and his or
her option for the current Offering Period will be automatically terminated, and
no further Contributions for the purchase of Shares will be made during the
Offering Period.

      10.2. Upon termination of the participant's Continuous Status as an
Employee prior to the Offering Termination Date of an Offering Period for any
reason, including retirement or death, the Contributions credited to his or her
account will be returned to him or her or, in the case of his or her death, to
the person or persons entitled thereto under Section 14, and his or her option
will be automatically terminated.

      10.3. In the event an Employee fails to remain in Continuous Status as an
Employee of the Company for at least twenty (20) hours per week during the
Offering Period in which the employee is a participant, he or she will be deemed
to have elected to withdraw from the Plan and the Contributions credited to his
or her account will be returned to him or her and his or her option terminated.

      10.4. A participant's withdrawal during an Offering Period will not have
any effect upon his or her eligibility to participate in a succeeding Offering
Period or in any similar plan which may hereafter be adopted by the Company.

11.   INTEREST

      No interest shall accrue on the Contributions of a participant in the
Plan.

12.   STOCK

      12.1. Subject to adjustment as provided in Section 18, the maximum number
of Shares which shall be made available for sale under the Plan shall be
_____________(2) Shares. If the Board determines that, on a given Offering
Termination Date, the number of shares with respect

----------
2.    This number will represent 1% of the Company on a fully diluted basis
      immediately after the closing of the IPO.
<PAGE>
                                      -6-

to which options are to be exercised may exceed (i) the number of shares of
Common Stock that were available for sale under the Plan on the Offering
Commencement Date, or (ii) the number of shares available for sale under the
Plan on such Offering Termination Date, the Board may in its sole discretion
provide that the Company shall make a pro rata allocation of the Shares
available for purchase on such Offering Commencement Date or Offering
Termination Date, as applicable, in as uniform a manner as shall be practicable
and as it shall determine in its sole discretion to be equitable among all
participants exercising options to purchase Common Stock on such Offering
Termination Date. The Company may make pro rata allocation of the Shares
available on the Offering Commencement Date of the applicable Offering Period
pursuant to the preceding sentence, notwithstanding any authorization of
additional Shares for issuance under the Plan by the Company's stockholders
subsequent to such Offering Commencement Date.

      12.2. The participant shall have no interest or voting right in Shares
covered by his or her option until such option has been exercised.

      12.3. Shares to be delivered to a participant under the Plan will be
registered in the name of the participant or in the name of the participant and
his or her spouse, as directed by the participant.

13.   ADMINISTRATION

      The Board, or a committee named by the Board, shall supervise and
administer the Plan and shall have full power to adopt, amend and rescind any
rules deemed desirable and appropriate for the administration of the Plan and
not inconsistent with the Plan, to construe and interpret the Plan, and to make
all other determinations necessary or advisable for the administration of the
Plan. The Board's determinations made in good faith on matters referred to in
this Plan shall be final, binding and conclusive on all persons having or
claiming any interest under this Plan.

14.   DESIGNATION OF BENEFICIARY

      14.1. A participant may file a written designation of a beneficiary who is
to receive any Shares and cash, if any, from the participant's account under the
Plan in the event of such participant's death subsequent to the end of an
Offering Period but prior to delivery to him or her of such Shares and cash. Any
such beneficiary shall also be entitled to receive any cash from the
participant's account under the Plan in the event of such participant's death
prior to the Offering Termination Date of an Offering Period.

      14.2. Such designation of beneficiary may be changed by the participant at
any time by written notice. In the event of the death of a participant and in
the absence of a beneficiary validly designated under the Plan who is living at
the time of such participant's death, the Company shall deliver such Shares
and/or cash to the executor or administrator of the estate of the participant,
or if no such executor or administrator has been appointed (to the knowledge of
the Company), the Company, in its discretion, may deliver such Shares and/or
cash to the spouse or to any one or more dependents or relatives of the
participant, or if no spouse, dependent or relative is known to the Company,
then to such other person as the Company may designate.

15.   TRANSFERABILITY OF OPTIONS AND SHARES

      Neither Contributions credited to a participant's account nor any rights
with regard to the exercise of an option or to receive Shares under the Plan may
be assigned, transferred, pledged or
<PAGE>
                                      -7-

otherwise disposed of in any way (other than by will, the laws of descent and
distribution, or as provided in Section 14) by the participant. Any such attempt
at assignment, transfer, pledge or other disposition shall be without effect,
except that the Company may treat such act as an election to withdraw funds in
accordance with Section 10. In addition, if the Board has so announced to
Employees at least five (5) days prior to the scheduled beginning of the next
Offering Period to be affected by the Board's determination, any Shares acquired
on the Offering Termination Date of such Offering Period may be subject to
restrictions specified by the Board on the transfer of such Shares. Any
participant selling or transferring any or all of his or her Shares purchased
pursuant to the Plan must provide written notice of such sale or transfer to the
Company within five business days after the date of sale or transfer. Such
notice to the Company shall include the gross sales price, if any, the Offering
Period during which the Shares being sold were purchased by the participant, the
number of Shares being sold or transferred and the date of sale or transfer.

16.   USE OF FUNDS

      All Contributions received or held by the Company under the Plan may be
used by the Company for any corporate purpose, and the Company shall not be
obligated to segregate such Contributions from its other assets.

17.   REPORTS

      Individual accounts will be maintained for each participant in the Plan.
Statements of account will be given to participating Employees at least
annually, which statements will set forth the amounts of Contributions, the per
Share Purchase Price, the number of Shares purchased and the remaining cash
balance, if any.

18.   ADJUSTMENTS UPON CHANGES IN CAPITALIZATION; CORPORATE TRANSACTIONS

      18.1. Adjustment. Subject to any required action by the stockholders of
the Company, the number of shares covered by each option under the Plan which
has not yet been exercised and the number of Shares which have been authorized
for issuance under the Plan but have not yet been placed under option
(collectively, the "Reserves"), as well as the maximum number of shares of
Common Stock which may be purchased by a participant in an Offering Period, the
number of shares of Common Stock set forth in Section 12.1 above, and the price
per Share of Common Stock covered by each option under the Plan which has not
yet been exercised, shall be proportionately adjusted for any increase or
decrease in the number of the Company's issued Shares resulting from a stock
split, reverse stock split, stock dividend, combination or reclassification of
the Common Stock (including any such change in the number of Shares of Common
Stock effected in connection with a change in domicile of the Company), or any
other increase or decrease in the number of Shares effected without receipt of
consideration by the Company; provided however that conversion of any
convertible securities of the Company shall not be deemed to have been "effected
without receipt of consideration." Such adjustment shall be made by the Board,
whose determination in that respect shall be final, binding and conclusive.

      18.2. Corporate Transactions. In the event of a dissolution or liquidation
of the Company, the Offering Period then in progress will terminate immediately
prior to the consummation of such action, unless otherwise provided by the
Board. In the event of a Corporate Transaction, each option outstanding under
the Plan shall be assumed or an equivalent option shall be substituted by the
successor corporation or a parent or Subsidiary of such
<PAGE>
                                      -8-

successor corporation. In the event that the successor corporation refuses to
assume or substitute for outstanding options, the Offering Period then in
progress shall be shortened and a new Offering Termination Date shall be set
(the "New Offering Termination Date"), as of which date the Offering Period then
in progress will terminate. The New Offering Termination Date shall be on or
before the date of consummation of the transaction and the Board shall notify
each participant in writing, at least ten (10) days prior to the New Offering
Termination Date, that the Offering Termination Date for his or her option has
been changed to the New Offering Termination Date and that his or her option
will be exercised automatically on the New Offering Termination Date, unless
prior to such date he or she has withdrawn from the Offering Period as provided
in Section 10. For purposes of this Section 18, an option granted under the Plan
shall be deemed to be assumed, without limitation, if, at the time of issuance
of the stock or other consideration upon a Corporate Transaction, each holder of
an option under the Plan would be entitled to receive upon exercise of the
option the same number and kind of shares of stock or the same amount of
property, cash or securities as such holder would have been entitled to receive
upon the occurrence of the transaction if the holder had been, immediately prior
to the transaction, the holder of the number of Shares of Common Stock covered
by the option at such time (after giving effect to any adjustments in the number
of Shares covered by the option as provided for in this Section 18); provided
however that if the consideration received in the transaction is not solely
common stock of the successor corporation or its parent (as defined in Section
424(e) of the Code), the Board may, with the consent of the successor
corporation, provide for the consideration to be received upon exercise of the
option to be solely common stock of the successor corporation or its parent
equal in Fair Market Value to the per Share consideration received by holders of
Common Stock in the transaction.

      The Board may, if it so determines in the exercise of its sole discretion,
also make provision for adjusting the Reserves, as well as the price per Share
of Common Stock covered by each outstanding option, in the event that the
Company effects one or more reorganizations, recapitalizations, rights offerings
or other increases or reductions of Shares of its outstanding Common Stock, and
in the event of the Company's being consolidated with or merged into any other
corporation.

19.   AMENDMENT OR TERMINATION

      19.1. The Board may at any time and for any reason terminate or amend the
Plan. Except as provided in Section 18, no termination of the Plan may affect
options previously granted, provided that the Plan or an Offering Period may be
terminated by the Board on an Offering Termination Date or by the Board's
setting a new Offering Termination Date with respect to an Offering Period then
in progress if the Board determines that termination of the Plan and/or the
Offering Period is in the best interests of the Company and its stockholders or
if continuation of the Plan and/or the Offering Period would cause the Company
to incur adverse accounting charges as a result of the Plan. Except as provided
in Section 18 and in this Section 19, no amendment to the Plan shall make any
change in any option previously granted which adversely affects the rights of
any participant.

      19.2. In addition to the foregoing, without stockholder consent and
without regard to whether any participant rights may be considered to have been
adversely affected, the Board (or its committee) shall be entitled to change the
Offering Periods, limit the frequency and/or number of changes in the amount
withheld during an Offering Period, establish the exchange ratio applicable to
amounts withheld in a currency other than U.S. dollars, permit payroll
withholding in excess of the amount designated by a participant in order to
adjust for delays or mistakes in the
<PAGE>
                                      -9-

Company's processing of properly completed withholding elections, establish
reasonable waiting and adjustment periods and/or accounting and crediting
procedures to ensure that amounts applied toward the purchase of Common Stock
for each participant properly correspond with amounts withheld from the
participant's Compensation, and establish such other limitations or procedures
as the Board (or its committee) determines in its sole discretion advisable
which are consistent with the Plan.

20.   NOTICES

      Any notice, demand, request or other communication hereunder to any party
shall be deemed to be sufficient if contained in a written instrument delivered
in person or duly sent by first class registered, certified or overnight mail,
postage prepaid, or telecopied with a confirmation copy by regular, certified or
overnight mail, addressed or telecopied, as the case may be, (i) if to the
recipient of an Award, at his or her residence address last filed with the
Company and (ii) if to the Company, at its principal place of business,
addressed to the attention of its Chief Executive Officer, or to such other
address or telecopier number, as the case may be, as the addressee may have
designated by notice to the addressor. All such notices, requests, demands and
other communications shall be deemed to have been received: (i) in the case of
personal delivery, on the date of such delivery; (ii) in the case of mailing,
when received by the addressee; and (iii) in the case of facsimile transmission,
when confirmed by facsimile machine report connection with the Plan shall be
deemed to have been duly given when received in the form specified by the
Company at the location, or by the person, designated by the Company for the
receipt thereof.

21.   CONDITIONS TO ISSUANCE OF SHARES

      Shares shall not be issued with respect to an option unless the exercise
of such option and the issuance and delivery of such Shares pursuant thereto
shall comply with all applicable provisions of law, domestic or foreign,
including, without limitation, the Securities Act of 1933, as amended, the
Exchange Act, the rules and regulations promulgated thereunder, applicable state
securities laws and the requirements of any stock exchange upon which the Shares
may then be listed, and shall be further subject to the approval of counsel for
the Company with respect to such compliance.

      As a condition to the exercise of an option, the Company may require the
person exercising such option to represent and warrant at the time of any such
exercise that the Shares are being purchased only for investment and without any
present intention to sell or distribute such Shares if, in the opinion of
counsel for the Company, such a representation is required by any of the
aforementioned applicable provisions of law.

22.   TERM OF PLAN; EFFECTIVE DATE

      The Plan shall become effective upon the IPO Date. It shall continue in
effect for a term of five (5) years unless sooner terminated under Section 19.
<PAGE>
                                                FORM OF SUBSCRIPTION AGREEMENT

                            AMICUS THERAPEUTICS, INC.

                        2006 EMPLOYEE STOCK PURCHASE PLAN

                             SUBSCRIPTION AGREEMENT

New Election: ___

Change of Election: ___

       1. I, __________________, hereby elect to participate in the Amicus
Therapeutics, Inc. 2006 Employee Stock Purchase Plan (as amended, the "Plan")
for the Offering Period ______________ ___, ______ to ______________ ___, _____,
and subscribe to purchase shares of the Company's Common Stock in accordance
with this Subscription Agreement and the Plan.

      2. I elect to have Contributions in the amount of _____% of my
Compensation, as those terms are defined in the Plan, applied to this purchase.
I understand that this amount must not be less than 1% and not more than 15% of
my Compensation during the Offering Period. (Please note that no fractional
percentages are permitted).

      3. I hereby authorize payroll deductions from each paycheck during the
Offering Period at the rate stated in Item 2 of this Subscription Agreement. I
understand that all payroll deductions made by me shall be credited to my
account under the Plan and that I may not make any additional payments into such
account. I understand that all payments made by me shall be accumulated, without
interest or earnings, for the purchase of shares of Common Stock at the
applicable purchase price determined in accordance with the Plan. I further
understand that, except as otherwise set forth in the Plan, shares will be
purchased for me automatically on the Offering Termination Date of each Offering
Period unless I otherwise withdraw from the Plan by giving written notice to the
Company for such purpose.

      4. I understand that I may discontinue at any time prior to the Offering
Termination Date my participation in the Plan as provided in Section 10 of the
Plan. I acknowledge that, unless I discontinue my participation in the Plan as
provided in Section 10 of the Plan, my election will continue to be effective
for each successive Offering Period.

      5.    I have received a copy of the complete Amicus Therapeutics, Inc.
2006 Employee Stock Purchase Plan.  I understand that my participation in the
Plan is in all respects subject to the terms of the Plan.

      6.    Shares purchased for me under the Plan should be issued in the
name(s) of (name of employee or employee and spouse only):

                           _________________________

                           _________________________

      7. In the event of my death, I hereby designate the following as my
beneficiary(ies) to receive all payments and shares due to me under the Plan:
<PAGE>
                                      -2-

NAME: (Please print)                              ______________________________
                                                  (First)     (Middle)    (Last)

___________________________                       ______________________________
(Relationship)                                    (Address)

                                                  ______________________________

      8. I understand that if I dispose of any shares received by me pursuant to
the Plan within 2 years after the Offering Commencement Date (the first day of
the Offering Period during which I purchased such shares) or within 1 year after
the Offering Termination Date, I will be treated for federal income tax purposes
as having received ordinary compensation income at the time of such disposition
in an amount equal to the excess of the fair market value of the shares on the
Offering Termination Date over the price which I paid for the shares, regardless
of whether I disposed of the shares at a price less than their fair market value
at the Offering Termination Date. The remainder of the gain or loss, if any,
recognized on such disposition will be treated as capital gain or loss.

      I hereby agree to notify the Company in writing within 30 days after the
date of any such disposition, and I will make adequate provision for federal,
state or other tax withholding obligations, if any, which arise upon the
disposition of the Common Stock. The Company may, but will not be obligated to,
withhold from my compensation the amount necessary to meet any applicable
withholding obligation including any withholding necessary to make available to
the Company any tax deductions or benefits attributable to the sale or early
disposition of Common Stock by me.

      9. If I dispose of such shares at any time after expiration of the 2-year
and 1-year holding periods, I understand that I will be treated for federal
income tax purposes as having received compensation income only to the extent of
an amount equal to the lesser of (1) the excess of the fair market value of the
shares at the time of such disposition over the purchase price which I paid for
the shares under the option, or (2) 15% of the fair market value of the shares
on the Offering Commencement Date. The remainder of the gain or loss, if any,
recognized on such disposition will be treated as capital gain or loss.

      I understand that this tax summary is only a summary and is subject to
change. I further understand that I should consult a tax advisor concerning
certain tax implications of the purchase and sale of stock under the Plan.

      10.   I hereby agree to be bound by the terms of the Plan.  The
effectiveness of this Subscription Agreement is dependent upon my eligibility
to participate in the Plan.

                                           SIGNATURE:___________________________

                                           SOCIAL SECURITY #:___________________

                                           DATE:________________________________
<PAGE>
                                                  FORM OF NOTICE OF WITHDRAWAL

                            AMICUS THERAPEUTICS, INC.

                        2006 EMPLOYEE STOCK PURCHASE PLAN

                              NOTICE OF WITHDRAWAL

      I, _____________, hereby elect to withdraw my participation in the Amicus
Therapeutics, Inc. 2006 Employee Stock Purchase Plan (the "Plan") for the
Offering Period that began on _________________, ________. This withdrawal
covers all Contributions credited to my account and is effective on the date
designated below.

      I understand that all Contributions credited to my account will be paid to
me within ten (10) business days of receipt by the Company of this Notice of
Withdrawal and that my option for the current period will automatically
terminate, and that no further Contributions for the purchase of shares can be
made by me during the Offering Period.

      The undersigned further understands and agrees that he or she shall be
eligible to participate in succeeding Offering Periods only by delivering to the
Company a new Subscription Agreement.

Dated:_______________                             ______________________________
                                                      Signature of Employee

                                                  ______________________________
                                                      Social Security Number

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