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CONFORMED COPY
                              Shire Finance Limited

                 2% Senior Guaranteed Convertible Notes Due 2011

                                  Guaranteed by

                         Shire Pharmaceuticals Group plc

                          Registration Rights Agreement

                                                                 August 21, 2001
Bear, Stearns International Limited
Goldman Sachs International
As representatives of the several Purchasers
   named in Schedule I to the Purchase Agreement
c/o Bear, Stearns International Limited,
One Canada Square,
London, E14 5AD,
England

Ladies and Gentlemen:

     Shire Finance Limited, an exempted limited company organized under the laws
of the Cayman Islands (the "Company"), proposes to issue to the Purchasers (as
defined herein) upon the terms set forth in the Purchase Agreement (as defined
herein) its 2% Senior Guaranteed Convertible Notes Due 2011 (the "Securities")
convertible into exchangeable redeemable preference shares of the Company (the
"Preference Shares") that will be exchanged for ordinary shares of Shire
Pharmaceuticals Group plc, a public limited liability company organized under
the laws of England and Wales ("Shire") or, at Shire's option, cash. As an
inducement to the Purchasers to enter into the Purchase Agreement and in
satisfaction of a condition to the obligations of the Purchasers thereunder, the
Company and Shire agree with the Purchasers for the benefit of Holders (as
defined herein) from time to time of the Registrable Securities (as defined
herein) as follows:

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     1. Definitions.

     (a) Capitalized terms used herein without definition shall have the
meanings ascribed to them in the Purchase Agreement. As used in this Agreement,
the following defined terms shall have the following meanings:

     "Act" or "Securities Act" means the United States Securities Act of 1933,
as amended.

     "ADSs" means the American Depositary Shares representing the Ordinary
Shares issuable upon conversion of the Securities.

     "Affiliate" of any specified person means any other person which, directly
or indirectly, is in control of, is controlled by, or is under common control
with such specified person. For purposes of this definition, control of a person
means the power, direct or indirect, to direct or cause the direction of the
management and policies of such person whether by contract or otherwise; and the
terms "controlling" and "controlled" have meanings correlative to the foregoing.

     "Closing Date" means the First Time of Delivery as defined in the Purchase
Agreement.

     "Commission" means the United States Securities and Exchange Commission, or
any other federal agency at the time administering the Exchange Act or the
Securities Act, whichever is the relevant statute for the particular purpose.

     "DTC" means The Depository Trust Company.

     "Effective Date" has the meaning assigned thereto in Section 2(b)(i)
hereof.

     "Effective Failure" has the meaning assigned thereto in Section 7(b)
hereof.

     "Effectiveness Period" has the meaning assigned thereto in Section 2(b)(i)
hereof.

     "Effective Time" means the time at which the Commission declares the Shelf
Registration Statement effective or at which the Shelf Registration Statement
otherwise becomes effective.

     "Electing Holder" has the meaning assigned thereto in Section 3(a)(iii)
hereof.

     "Exchange Act" means the United States Securities Exchange Act of 1934, as
amended.

     "Holder" means, any person that is the record owner of Registrable
Securities (and includes any person that has a beneficial interest in any
Registrable Security in book-entry form).

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     "Indenture" means the Indenture, dated as of August 21, 2001, among Shire,
the Company and The Bank of New York, as amended and supplemented from time to
time in accordance with its terms.

     "Liquidated Damages" has the meaning assigned thereto in Section 7(a)
hereof.

     "Managing Underwriters" means the investment banker or investment bankers
and manager or managers that shall administer an underwritten offering, if any,
conducted pursuant to Section 6 hereof.

     "NASD Rules" means the Rules of the National Association of Securities
Dealers, Inc., as amended from time to time.

     "Notice and Questionnaire" means a Notice of Registration Statement and
Selling Securityholder Questionnaire substantially in the form of Appendix A
hereto.

     "Ordinary Shares" means Shire's ordinary shares, nominal value 5p per
share.

     The term "person" means an individual, partnership, corporation, trust or
unincorporated organization, or a government or agency or political subdivision
thereof.

     "Prospectus" means the prospectus (including, without limitation, any
preliminary prospectus, any final prospectus and any prospectus that discloses
information previously omitted from a prospectus filed as part of an effective
registration statement in reliance upon Rule 430A under the Act) included in the
Shelf Registration Statement, as amended or supplemented by any prospectus
supplement with respect to the terms of the offering of any portion of the
Registrable Securities covered by the Shelf Registration Statement and by all
other amendments and supplements to such prospectus, including all material
incorporated by reference in such prospectus and all documents filed after the
date of such prospectus by Shire under the Exchange Act and incorporated by
reference therein.

     "Purchasers" means the Purchasers named in Schedule I to the Purchase
Agreement.

     "Purchase Agreement" means the purchase agreement, dated as of August 15,
2001, among the Purchasers, Shire and the Company relating to the Securities.

     "Registrable Securities" means all or any portion of the Securities issued
from time to time under the Indenture and the Ordinary Shares (including the
Ordinary Shares underlying the ADSs) issuable in exchange for Preference Shares;
provided, however, that a security ceases to be a Registrable Security when it
is no longer a Restricted Security.

     "Registration Default" has the meaning assigned thereto in Section 7(a)
hereof.

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     "Representatives" means Bear, Stearns International Limited and Goldman
Sachs International as representatives of the several Purchasers.

     "Restricted Security" means any Security or Ordinary Share issuable in
exchange for Preference Shares except any such Security or Ordinary Share that
(i) has been effectively registered under the Securities Act and sold in a
manner contemplated by the Shelf Registration Statement, (ii) has been
transferred in compliance with Rule 144 under the Securities Act (or any
successor provision thereto) or is transferable pursuant to paragraph (k) of
such Rule 144 (or any successor provision thereto) by a non-Affiliate, or (iii)
has otherwise been transferred and a new Security or Ordinary Share not subject
to transfer restrictions under the Securities Act has been delivered by or on
behalf of the Company in accordance with Section 3.5 of the Indenture.

     "Rules and Regulations" means the published rules and regulations of the
Commission promulgated under the Securities Act or the Exchange Act, as in
effect at any relevant time.

     "Shelf Registration" means a registration effected pursuant to Section 2
hereof.

     "Shelf Registration Statement" means a "shelf" registration statement filed
under the Securities Act providing for the registration of, and the sale on a
continuous or delayed basis by the Holders of, all of the Registrable Securities
pursuant to Rule 415 under the Securities Act and/or any similar rule that may
be adopted by the Commission, filed by the Company and Shire pursuant to the
provisions of Section 2 of this Agreement, including the Prospectus contained
therein, any amendments and supplements to such registration statement,
including post-effective amendments, and all exhibits and all material
incorporated by reference in such registration statement.

     "Trust Indenture Act" means the Trust Indenture Act of 1939, or any
successor thereto, and the rules, regulations and forms promulgated thereunder,
as the same shall be amended from time to time.

     The term "underwriter" means any underwriter of Registrable Securities in
connection with an offering thereof under a Shelf Registration Statement.

     (b) Wherever there is a reference in this Agreement to a percentage of the
"principal amount" of Registrable Securities or to a percentage of Registrable
Securities, Ordinary Shares shall be treated as representing the principal
amount of Securities that was surrendered for conversion or exchange in order to
receive such number of Ordinary Shares.

     2. Shelf Registration.

     (a) The Company and Shire shall, no later than 90 calendar days following
the Closing Date, file with the Commission a Shelf Registration Statement
relating to the offer and

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sale of the Registrable Securities by the Holders from time to time in
accordance with the methods of distribution elected by such Holders (provided
that such methods of distribution will take the form of an underwritten offering
only with the prior consent of Shire in its sole discretion) and set forth in
such Shelf Registration Statement and, thereafter, shall use its reasonable best
efforts to cause such Shelf Registration Statement to be declared effective
under the Act no later than 180 calendar days following the Closing Date;
provided, however, that Shire may, upon written notice to all Holders, postpone
having the Shelf Registration Statement declared effective for a reasonable
period not to exceed 90 days if Shire possesses material non-public information
(i), the disclosure of which would have a material adverse effect on Shire and
its subsidiaries taken as a whole, or (ii) relating to a previously undisclosed
proposed or pending transaction and, in Shire's reasonable belief, its
disclosure would impede Shire's ability to consummate such transaction;
provided, further, however, that no Holder shall be entitled to be named as a
selling securityholder in the Shelf Registration Statement or to use the
Prospectus forming a part thereof for resales of Registrable Securities unless
such Holder is an Electing Holder.

     (b) Each of the Company and Shire shall use its reasonable best efforts:

          (i) to keep the Shelf Registration Statement continuously effective in
     order to permit the Prospectus forming a part thereof to be usable by
     Holders until the earliest of (A) the sale of all Registrable Securities
     registered under the Shelf Registration Statement; (B) the expiration of
     the period referred to in Rule 144(k) of the Act with respect to all
     Registrable Securities held by Persons that are not Affiliates of Shire or
     the Company; and (C) two years from the date (the "Effective Date") such
     Shelf Registration Statement is declared effective (the period ending on
     the earliest of such dates being referred to herein as the "Effectiveness
     Period");

          (ii) after the Effective Time of the Shelf Registration Statement, as
     promptly as is practicable upon the request of any Holder of Registrable
     Securities that is not then an Electing Holder, to take any action
     reasonably necessary to enable such Holder to use the Prospectus forming a
     part thereof for resales of Registrable Securities, including, without
     limitation, any action necessary to identify such Holder as a selling
     securityholder in the Shelf Registration Statement, such as the filing with
     the Commission of a Post-Effective Amendment relating to the Shelf
     Registration Statement; provided, however, that nothing in this
     subparagraph shall relieve such Holder of the obligation to return a
     completed and signed Notice and Questionnaire to the Company in accordance
     with Section 3(a)(ii) hereof; and

          (iii) if at any time the Securities, pursuant to Article 7 of the
     Indenture, are convertible into securities other than Preference Shares,
     Ordinary Shares or ADSs, to cause, or to cause any successor under the
     Indenture to cause, such securities to be

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     included in the Shelf Registration Statement no later than the date on
     which the Securities may then be convertible into such securities.

     The Company and Shire shall be deemed not to have used their reasonable
best efforts to keep the Shelf Registration Statement effective during the
requisite period if the Company or Shire, respectively, voluntarily takes any
action that would result in Holders of Registrable Securities covered thereby
not being able to offer and sell any of such Registrable Securities during that
period, unless such action is (A) required by applicable law and the Company
and/or Shire, as applicable, thereafter promptly complies with the requirements
of Section 3(j) below or (B) permitted pursuant to Section 2(c) below.

     (c) Shire may suspend the use of the Prospectus for a period not to exceed
45 days if the Board of Directors of Shire shall have determined in good faith
that because of valid business reasons (not including avoidance of Shire's
obligations hereunder), including but not limited to the acquisition or
divestiture of assets, pending corporate developments and similar events, it is
in the best interest of Shire to suspend such use; provided, that Shire can
extend such suspension for up to 75 days in any 90-day period or an aggregate of
90 days in any 12-month period (i) if Shire possesses material non-public
information (A) the disclosure of which would have a material adverse effect on
Shire and its subsidiaries taken as a whole, or (B) relating to an undisclosed
proposed or pending transaction and, in Shire's reasonable belief, its
disclosure would impede Shire's ability to consummate such transaction or (ii)
otherwise with the prior written consent of the Representatives. Shire shall,
prior to suspending the use of the Prospectus or extending an existing
suspension, provide the Holders with written notice of such suspension, which
notice need not specify the nature of the event giving rise to such suspension.

     3. Registration Procedures. In connection with the Shelf Registration
Statement, the following provisions shall apply:

          (a) (i) Not less than 30 calendar days prior to the Effective Time of
     the Shelf Registration Statement, the Company shall mail the Notice and
     Questionnaire to the Holders of Registrable Securities. No Holder shall be
     entitled to be named as a selling securityholder in the Shelf Registration
     Statement as of the Effective Time, and no Holder shall be entitled to use
     the Prospectus forming a part thereof for resales of Registrable Securities
     at any time, unless such Holder has returned a completed and signed Notice
     and Questionnaire to the Company by the deadline for response set forth
     therein; provided, however, Holders of Registrable Securities shall have at
     least 21 calendar days from the date on which the Notice and Questionnaire
     is first mailed to such Holders to return a completed and signed Notice and
     Questionnaire to the Company.

          (ii) After the Effective Time of the Shelf Registration Statement, the
     Company shall, upon the request of any Holder of Registrable Securities
     that is not then an Electing

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     Holder, as promptly as is practicable send a Notice and Questionnaire to
     such Holder. The Company shall not be required to take any action to name
     such Holder as a selling securityholder in the Shelf Registration Statement
     or to enable such Holder to use the Prospectus forming a part thereof for
     resales of Registrable Securities until such Holder has returned a
     completed and signed Notice and Questionnaire to the Company.

          (iii) The term "Electing Holder" shall mean any Holder of Registrable
     Securities that has returned a completed and signed Notice and
     Questionnaire to the Company in accordance with Section 3(a)(i) or 3(a)(ii)
     hereof.

     (b) The Company shall furnish to each Electing Holder, prior to the
Effective Time, a copy of the Shelf Registration Statement initially filed with
the Commission, and shall furnish to such Holders, prior to the filing thereof
with the Commission, copies of each amendment thereto and each amendment or
supplement, if any, to the Prospectus included therein, and each of the Company
and Shire shall use its best efforts to reflect in each such document, at the
Effective Time or when so filed with the Commission, as the case may be, such
comments as such Holders and their respective counsel reasonably may propose.

     (c) The Company and Shire shall promptly take such action as may be
necessary so that (i) each of the Shelf Registration Statement and any amendment
thereto and the Prospectus forming a part thereof and any amendment or
supplement thereto (and each report or other document incorporated therein by
reference in each case) complies in all material respects with the Securities
Act and the Exchange Act and the respective rules and regulations thereunder,
(ii) each of the Shelf Registration Statement and any amendment thereto does
not, when it becomes effective, contain an untrue statement of a material fact
or omit to state a material fact required to be stated therein or necessary to
make the statements therein not misleading and (iii) each of the Prospectuses
forming a part of the Shelf Registration Statement, and any amendment or
supplement to such Prospectus, does not at any time during the Effectiveness
Period include an untrue statement of a material fact or omit to state a
material fact necessary in order to make the statements therein, in the light of
the circumstances under which they were made, not misleading.

     (d) The Company or Shire shall as promptly as is practicable advise each
Electing Holder, and shall confirm such advice in writing if so requested by any
such Electing Holder:

          (i) when a Shelf Registration Statement and any amendment thereto has
     been filed with the Commission and when a Shelf Registration Statement or
     any post-effective amendment thereto has become effective, in each case
     making a public announcement thereof by release made to Reuters Economic
     Services or Bloomberg Business News;

          (ii) of any request by the Commission for amendments or supplements to
     the Shelf Registration Statement or the Prospectus included therein or for
     additional information;

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<PAGE>

          (iii) of the issuance by the Commission of any stop order suspending
     the effectiveness of the Shelf Registration Statement or the initiation of
     any proceedings for such purpose;

          (iv) of the receipt by the Company or Shire of any notification with
     respect to the suspension of the qualification of the securities included
     in the Shelf Registration Statement for sale in any jurisdiction or the
     initiation of any proceeding for such purpose; and

          (v) of the happening of any event or the existence of any state of
     facts that requires the making of any changes in the Shelf Registration
     Statement or the Prospectus included therein so that, as of such date, such
     Shelf Registration Statement and Prospectus do not contain an untrue
     statement of a material fact and do not omit to state a material fact
     required to be stated therein or necessary to make the statements therein
     (in the case of the Prospectus, in light of the circumstances under which
     they were made) not misleading (which advice shall be accompanied by an
     instruction to such Holders to suspend the use of the Prospectus until the
     requisite changes have been made).

     (e) Each of the Company and Shire shall use its best efforts to prevent the
issuance, and if issued to obtain the withdrawal at the earliest possible time,
of any order suspending the effectiveness of the Shelf Registration Statement.

     (f) The Company or Shire shall furnish to each Electing Holder, without
charge, at least one copy of the Shelf Registration Statement and all
post-effective amendments thereto, including financial statements and schedules,
and, if such Electing Holder so requests in writing, all reports, other
documents and exhibits that are filed with or incorporated by reference in the
Shelf Registration Statement.

     (g) The Company or Shire shall, during the Effectiveness Period, deliver to
each Electing Holder, without charge, as many copies of the Prospectus
(including each preliminary Prospectus) included in the Shelf Registration
Statement and any amendment or supplement thereto as such Electing Holder may
reasonably request; and the Company and Shire consent (except during the periods
specified in Section 2(c) above or during the continuance of any event described
in Section 3(d)(v) above) to the use of the Prospectus and any amendment or
supplement thereto by each of the Electing Holders in connection with the
offering and sale of the Registrable Securities covered by the Prospectus and
any amendment or supplement thereto during the Effectiveness Period.

     (h) Prior to any offering of Registrable Securities pursuant to the Shelf
Registration Statement, the Company and Shire shall (i) register or qualify or
cooperate with the Electing Holders and their respective counsel in connection
with the registration or qualification of such Registrable Securities for offer
and sale under the securities or "blue sky" laws of such

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jurisdictions within the United States as any Electing Holder may reasonably
request, (ii) keep such registrations or qualifications in effect and comply
with such laws so as to permit the continuance of offers and sales in such
jurisdictions for so long as may be necessary to enable any Electing Holder or
underwriter, if any, to complete its distribution of Registrable Securities
pursuant to the Shelf Registration Statement, and (iii) take any and all other
actions necessary or advisable to enable the disposition in such jurisdictions
of such Registrable Securities; provided, however, that in no event shall the
Company or Shire be obligated to (A) qualify as a foreign corporation or as a
dealer in securities in any jurisdiction where it would not otherwise be
required to so qualify but for this Section 3(h) or (B) file any general consent
to service of process or subject itself to taxation in excess of a nominal
amount in any jurisdiction where it is not as of the date hereof so subject.

     (i) Unless any Registrable Securities shall be in book-entry only form, the
Company and Shire shall cooperate with the Electing Holders to facilitate the
timely preparation and delivery of certificates representing Registrable
Securities to be sold pursuant to the Shelf Registration Statement, which
certificates, if so required by any securities exchange upon which any
Registrable Securities are listed, shall be penned, lithographed or engraved, or
produced by any combination of such methods, on steel engraved borders, and
which certificates shall be free of any restrictive legends and in such
permitted denominations and registered in such names as Electing Holders may
request in connection with the sale of Registrable Securities pursuant to the
Shelf Registration Statement.

     (j) Upon the occurrence of any fact or event contemplated by Section
3(d)(v) above, the Company and Shire shall as promptly as is practicable prepare
a post-effective amendment to any Shelf Registration Statement or an amendment
or supplement to the related Prospectus or file any other required document so
that, as thereafter delivered to purchasers of the Registrable Securities
included therein, the Prospectus will not include an untrue statement of a
material fact or omit to state any material fact necessary to make the
statements therein, in the light of the circumstances under which they were
made, not misleading. If the Company or Shire notifies the Electing Holders of
the occurrence of any fact or event contemplated by Section 3(d)(v) above, the
Electing Holder shall suspend the use of the Prospectus until the requisite
changes to the Prospectus have been made.

     (k) Not later than the Effective Time of the Shelf Registration Statement,
the Company or Shire shall provide a CUSIP number for the Registrable Securities
that are debt securities.

     (l) Each of the Company and Shire shall use its best efforts to comply with
all applicable Rules and Regulations, and to make generally available to its
securityholders as soon as practicable, but in any event not later than eighteen
months after (i) the effective date (as defined in Rule 158(c) under the
Securities Act) of the Shelf Registration Statement, (ii) the

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effective date of each post-effective amendment to the Shelf Registration
Statement and (iii) the date of each filing by Shire with the Commission of an
Annual Report on Form 10-K that is incorporated by reference in the Shelf
Registration Statement, an earning statement of Shire and its subsidiaries
complying with Section 11(a) of the Securities Act and the rules and regulations
of the Commission thereunder (including, at the option of the Company, Rule
158).

     (m) Not later than the Effective Time of the Shelf Registration Statement,
the Company and Shire shall cause the Indenture to be qualified under the Trust
Indenture Act; in connection with such qualification, the Company and Shire
shall cooperate with the Trustee under the Indenture and the Holders (as defined
in the Indenture) to effect such changes to the Indenture as may be required for
such Indenture to be so qualified in accordance with the terms of the Trust
Indenture Act; and the Company and Shire shall execute, and shall use all
reasonable efforts to cause the Trustee to execute, all documents that may be
required to effect such changes and all other forms and documents required to be
filed with the Commission to enable such Indenture to be so qualified in a
timely manner. In the event that any such amendment or modification referred to
in this Section 3(m) involves the appointment of a new trustee under the
Indenture, the Company and Shire shall appoint a new trustee thereunder pursuant
to the applicable provisions of the Indenture.

     (n) In the event of an underwritten offering conducted pursuant to Section
6 hereof, the Company and Shire shall, if requested, as promptly as is
practicable include or incorporate in a Prospectus supplement or post-effective
amendment to the Shelf Registration Statement such information as the Managing
Underwriters reasonably agree should be included therein and to which Shire does
not reasonably object and shall make all required filings of such Prospectus
supplement or post-effective amendment as soon as practicable after it is
notified of the matters to be included or incorporated in such Prospectus
supplement or post-effective amendment.

     (o) The Company and Shire shall enter into such customary agreements
(including an underwriting agreement in customary form in the event of an
underwritten offering conducted pursuant to Section 6 hereof) and take all other
appropriate action in order to expedite and facilitate the registration and
disposition of the Registrable Securities, and in connection therewith, if an
underwriting agreement is entered into, cause the same to contain
indemnification provisions and procedures substantially identical to those set
forth in Section 5 hereof with respect to all parties to be indemnified pursuant
to Section 5 hereof.

     (p) Each of the Company and Shire shall:

          (i)(A) make reasonably available for inspection by the Electing
     Holders, any underwriter participating in any disposition pursuant to the
     Shelf Registration Statement, and any attorney, accountant or other agent
     retained by such Electing Holders or any such underwriter all relevant
     financial and other records, pertinent corporate documents and

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<PAGE>

     properties of itself and its subsidiaries, and (B) cause its officers,
     directors and employees to supply all information reasonably requested by
     such Electing Holders or any such underwriter, attorney, accountant or
     agent in connection with the Shelf Registration Statement, in each case, as
     is customary for similar due diligence examinations; provided, however,
     that all records, information and documents that are designated in writing
     by the Company or Shire, as applicable, in good faith, as confidential
     shall be kept confidential by such Electing Holders and any such
     underwriter, attorney, accountant or agent, unless such disclosure is made
     in connection with a court proceeding or required by law, or such records,
     information or documents become available to the public generally or
     through a third party without an accompanying obligation of
     confidentiality; and provided further that, such inspection and information
     gathering shall, to the greatest extent possible, be coordinated on behalf
     of the Electing Holders and the other parties entitled thereto by one
     counsel designated by and on behalf of the Electing Holders and other
     parties;

          (ii) in connection with any underwritten offering conducted pursuant
     to Section 6 hereof, make such representations and warranties to the
     Managing Underwriters, in form, substance and scope as are customarily made
     by Shire to underwriters in primary underwritten offerings of equity and
     convertible debt securities and covering matters customarily covered in
     such offerings, including, but not limited to, those set forth in the
     Purchase Agreement;

          (iii) in connection with any underwritten offering conducted pursuant
     to Section 6 hereof, obtain opinions of counsel to the Company and Shire
     (which counsel and opinions (in form, scope and substance) shall be
     reasonably satisfactory to the Managing Underwriters) addressed to the
     underwriters, covering such matters as are customarily covered in opinions
     requested in primary underwritten offerings of equity and convertible debt
     securities (it being agreed that the matters to be covered by such opinions
     shall include, without limitation, as of the date of the opinion and as of
     the Effective Time of the Shelf Registration Statement or most recent
     post-effective amendment thereto, as the case may be, the absence from the
     Shelf Registration Statement and the Prospectus, including the documents
     incorporated by reference therein, of an untrue statement of a material
     fact or the omission of a material fact required to be stated therein or
     necessary to make the statements therein (in the case of the Prospectus, in
     light of the circumstances under which they were made) not misleading;

          (iv) in connection with any underwritten offering conducted pursuant
     to Section 6 hereof, obtain "cold comfort" letters and updates thereof from
     the independent public accountants of Shire and the Company (and, if
     necessary, from the independent public accountants of any subsidiary of
     Shire or of any business acquired by Shire for which financial statements
     and financial data are, or are required to be, included in the Shelf
     Registration Statement), addressed to the underwriters, in customary form
     and

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<PAGE>

     covering matters of the type customarily covered in "cold comfort" letters
     in connection with primary underwritten offerings; and

          (v) in connection with any underwritten offering conducted pursuant to
     Section 6 hereof, deliver such documents and certificates as may be
     reasonably requested by the Managing Underwriters, if any, including,
     without limitation, certificates to evidence compliance with Section 3(j)
     hereof and with any conditions contained in the underwriting agreement or
     other agreements entered into by the Company.

     (q) Shire will use its reasonable best efforts to cause the Ordinary Shares
issuable upon conversion of the Securities to be listed on the London Stock
Exchange, the Luxembourg Stock Exchange or other stock exchange or trading
system on which the Ordinary Shares primarily trade.

     (r) In the event that any broker-dealer registered under the Exchange Act
shall be an "affiliate" (as defined in Rule 2720(b)(1) of the NASD Rules (or any
successor provision thereto)) of the Company or Shire or has a "conflict of
interest" (as defined in Rule 2720(b)(7) of the NASD Rules (or any successor
provision thereto)) and such broker-dealer shall underwrite, participate as a
member of an underwriting syndicate or selling group or assist in the
distribution of any Registrable Securities covered by the Shelf Registration
Statement, whether as a Holder of such Registrable Securities or as an
underwriter, a placement or sales agent or a broker or dealer in respect
thereof, or otherwise, the Company and Shire shall assist such broker-dealer in
complying with the requirements of the NASD Rules, including, without
limitation, by (i) engaging a "qualified independent underwriter" (as defined in
Rule 2720(b)(15) of the NASD Rules (or any successor provision thereto)) to
participate in the preparation of the registration statement relating to such
Registrable Securities, to exercise usual standards of due diligence in respect
thereto and to recommend the public offering price of such Registrable
Securities, (ii) indemnifying such qualified independent underwriter to the
extent of the indemnification of underwriters provided in Section 5 hereof, and
(iii) providing such information to such broker-dealer as may be required in
order for such broker-dealer to comply with the requirements of the NASD Rules.

     (s) Each of the Company and Shire shall use its reasonable best efforts to
take all other steps necessary to effect the registration, offering and sale of
the Registrable Securities covered by the Shelf Registration Statement
contemplated hereby.

     4. Registration Expenses. Except as otherwise provided in Section 3, the
Company and Shire, jointly and severally, shall bear all fees and expenses
incurred in connection with the performance of their obligations under Sections
2, 3 and 6 hereof and shall bear or reimburse the Electing Holders for the
reasonable fees and disbursements of Cleary, Gottlieb, Steen & Hamilton to act
as counsel therefor in connection therewith, which fees and disbursements shall

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not in the aggregate exceed $50,000. Each Electing Holder shall pay all
underwriting discounts and commissions and transfer taxes, if any, relating to
the sale or disposition of such Electing Holder's Registrable Securities
pursuant to the Shelf Registration Statement.

     5. Indemnification and Contribution.

     (a) Indemnification by the Company. Upon the registration of the
Registrable Securities pursuant to Section 2 hereof, the Company and Shire,
jointly and severally, shall indemnify and hold harmless each Electing Holder
and each underwriter, selling agent or other securities professional, if any,
which facilitates the disposition of Registrable Securities, and each of their
respective officers and directors and each person who controls such Electing
Holder, underwriter, selling agent or other securities professional within the
meaning of Section 15 of the Securities Act or Section 20 of the Exchange Act
(each such person being sometimes referred to as an "Indemnified Person")
against any losses, claims, damages or liabilities, joint or several, to which
such Indemnified Person may become subject under the Securities Act or
otherwise, insofar as such losses, claims, damages or liabilities (or actions in
respect thereof) ("losses") arise out of or are based upon an untrue statement
or alleged untrue statement of a material fact contained in any Shelf
Registration Statement under which such Registrable Securities are to be
registered under the Securities Act, or any Prospectus contained therein or
furnished by the Company or Shire to any Indemnified Person, or any amendment or
supplement thereto, or arise out of or are based upon the omission or alleged
omission to state therein a material fact required to be stated therein or
necessary to make the statements therein, in light of the circumstances under
which they were made, not misleading, and the Company hereby agrees to reimburse
such Indemnified Person for any legal or other expenses reasonably incurred by
them in connection with investigating or defending any such action or claim as
such expenses are incurred; provided, however, that neither the Company nor
Shire shall be liable to any such Indemnified Person in any such case to the
extent that any such loss, claim, damage or liability arises out of or is based
upon an untrue statement or alleged untrue statement or omission or alleged
omission made in such Shelf Registration Statement or Prospectus, or amendment
or supplement, in reliance upon and in conformity with written information
furnished to Shire by such Indemnified Person expressly for use therein; and
provided further, however, that neither the Company nor Shire shall be liable
for losses arising out of or based upon an untrue statement or alleged untrue
statement of a material fact contained in a preliminary Prospectus delivered to
an Indemnified Person if (i) the untrue statement contained in the preliminary
Prospectus is specifically cured in the final Prospectus, (ii) the final
Prospectus was required by law to be delivered at or prior to the written
confirmation of sale, (iii) the Company or Shire provided the Indemnified Person
with copies of the final Prospectus on a timely basis and (iv) the Indemnified
Person failed to deliver a final Prospectus prior to the written confirmation of
sale.

     (b) Indemnification by the Electing Holders and any Agents and
Underwriters. Each Electing Holder agrees, as a consequence of the inclusion of
any of such Electing Holder's

                                       13
<PAGE>

Registrable Securities in such Shelf Registration Statement, and each
underwriter, selling agent or other securities professional, if any, which
facilitates the disposition of Registrable Securities shall agree, as a
consequence of facilitating such disposition of Registrable Securities,
severally and not jointly, to (i) indemnify and hold harmless the Company,
Shire, and each of their directors, officers who sign any Shelf Registration
Statement and each person, if any, who controls the Company or Shire within the
meaning of either Section 15 of the Securities Act or Section 20 of the Exchange
Act, against any losses, claims, damages or liabilities to which the Company,
Shire or such other persons may become subject, under the Securities Act or
otherwise, insofar as such losses, claims, damages or liabilities (or actions in
respect thereof) arise out of or are based upon an untrue statement or alleged
untrue statement of a material fact contained in such Shelf Registration
Statement or Prospectus, or any amendment or supplement, or arise out of or are
based upon the omission or alleged omission to state therein a material fact
required to be stated therein or necessary to make the statements therein not
misleading, in each case to the extent, but only to the extent, that such untrue
statement or alleged untrue statement or omission or alleged omission was made
in reliance upon and in conformity with written information furnished to the
Company by such Electing Holder, underwriter, selling agent or other securities
professional expressly for use therein, and (ii) reimburse the Company and Shire
for any legal or other expenses reasonably incurred by the Company and Shire,
respectively, in connection with investigating or defending any such action or
claim as such expenses are incurred.

     (c) Notices of Claims, Etc. Promptly after receipt by an indemnified party
under subsection (a) or (b) above of notice of the commencement of any action,
such indemnified party shall, if a claim in respect thereof is to be made
against an indemnifying party under this Section 5, notify such indemnifying
party in writing of the commencement thereof; but the omission so to notify the
indemnifying party shall not relieve it from any liability which it may have to
any indemnified party otherwise than under this Section 5. In case any such
action shall be brought against any indemnified party and it shall notify an
indemnifying party of the commencement thereof, such indemnifying party shall be
entitled to participate therein and, to the extent that it shall wish, jointly
with any other indemnifying party similarly notified, to assume the defense
thereof, with counsel satisfactory to such indemnified party (who shall not,
except with the consent of the indemnified party, be counsel to the indemnifying
party), and, after notice from the indemnifying party to such indemnified party
of its election so to assume the defense thereof, such indemnifying party shall
not be liable to such indemnified party under this Section 5 for any legal
expenses of other counsel or any other expenses, in each case subsequently
incurred by such indemnified party, in connection with the defense thereof other
than reasonable costs of investigation unless such indemnified party shall have
reasonably concluded that there may be defenses available to it that are
different from or additional to those available to one or all of the
indemnifying parties, in which case the indemnifying party's liability for the
fees and expenses of the indemnified party's counsel shall continue. No
indemnifying party shall, without the

                                       14
<PAGE>

written consent of the indemnified party, effect the settlement or compromise
of, or consent to the entry of any judgment with respect to, any pending or
threatened action or claim in respect of which indemnification or contribution
may be sought hereunder (whether or not the indemnified party is an actual or
potential party to such action or claim) unless such settlement, compromise or
judgment (i) includes an unconditional release of the indemnified party from all
liability arising out of such action or claim and (ii) does not include a
statement as to, or an admission of, fault, culpability or a failure to act, by
or on behalf of any indemnified party.

     (d) Contribution. If the indemnification provided for in this Section 5 is
unavailable to or insufficient to hold harmless an indemnified party under
subsection (a) or (b) above in respect of any losses, claims, damages or
liabilities (or actions in respect thereof) referred to therein, then each
indemnifying party shall contribute to the amount paid or payable by such
indemnified party as a result of such losses, claims, damages or liabilities (or
actions in respect thereof) in such proportion as is appropriate to reflect the
relative fault of the indemnifying party and the indemnified party in connection
with the statements or omissions which resulted in such losses, claims, damages
or liabilities (or actions in respect thereof), as well as any other relevant
equitable considerations. The relative fault of such indemnifying party and
indemnified party shall be determined by reference to, among other things,
whether the untrue or alleged untrue statement of a material fact or omission or
alleged omission to state a material fact relates to information supplied by
such indemnifying party or by such indemnified party, and the parties' relative
intent, knowledge, access to information and opportunity to correct or prevent
such statement or omission. The parties hereto agree that it would not be just
and equitable if contribution pursuant to this Section 5(d) were determined by
pro rata allocation (even if the Electing Holders or any underwriters, selling
agents or other securities professionals or all of them were treated as one
entity for such purpose) or by any other method of allocation which does not
take account of the equitable considerations referred to in this Section 5(d).
The amount paid or payable by an indemnified party as a result of the losses,
claims, damages or liabilities (or actions in respect thereof) referred to above
shall be deemed to include any legal or other fees or expenses reasonably
incurred by such indemnified party in connection with investigating or defending
any such action or claim. No person guilty of fraudulent misrepresentation
(within the meaning of Section 11(f) of the Securities Act) shall be entitled to
contribution from any person who was not guilty of such fraudulent
misrepresentation. The obligations of the Electing Holders and any underwriters,
selling agents or other securities professionals in this Section 5(d) to
contribute shall be several in proportion to the percentage of principal amount
of Registrable Securities registered or underwritten, as the case may be, by
them and not joint.

     (e) Notwithstanding any other provision of this Section 5, in no event will
any (i) Electing Holder be required to undertake liability to any person under
this Section 5 for any amounts in excess of the dollar amount of the proceeds to
be received by such Holder from the sale of such Holder's Registrable Securities
(after deducting any fees, discounts and commissions applicable thereto)
pursuant to any Shelf Registration Statement under which such

                                       15
<PAGE>

Registrable Securities are to be registered under the Securities Act and (ii)
underwriter, selling agent or other securities professional be required to
undertake liability to any person hereunder for any amounts in excess of the
discount, commission or other compensation payable to such underwriter, selling
agent or other securities professional with respect to the Registrable
Securities underwritten by it and distributed to the public.

     (f) The obligations of the Company and Shire under this Section 5 shall be
in addition to any liability which they may otherwise have to any Indemnified
Person and the obligations of any Indemnified Person under this Section 5 shall
be in addition to any liability which such Indemnified Person may otherwise have
to the Company or Shire. The remedies provided in this Section 5 are not
exclusive and shall not limit any rights or remedies which may otherwise be
available to an indemnified party at law or in equity.

     6. Underwritten Offering. Any Holder of Registrable Securities who desires
to do so may sell Registrable Securities (in whole or in part) in an
underwritten offering, subject to the prior approval of Shire in its sole
discretion; provided that (i) the Electing Holders of at least 33-1/3% in
aggregate principal amount of the Registrable Securities then covered by the
Shelf Registration Statement shall request such an offering and (ii) at least
such aggregate principal amount of such Registrable Securities shall be included
in such offering. Upon receipt of such a request, the Company or Shire shall
provide all Holders of Registrable Securities written notice of the request,
which notice shall inform such Holders that they have the opportunity to
participate in the offering. In any such underwritten offering, the investment
banker or bankers and manager or managers that will administer the offering will
be selected by, and the underwriting arrangements with respect thereto
(including the size of the offering) will be approved by, the holders of a
majority of the Registrable Securities to be included in such offering;
provided, however, that such investment bankers and managers and underwriting
arrangements must be reasonably satisfactory to Shire. No Holder may participate
in any underwritten offering contemplated hereby unless (a) such Holder agrees
to sell such Holder's Registrable Securities to be included in the underwritten
offering in accordance with any approved underwriting arrangements, (b) such
Holder completes and executes all reasonable questionnaires, powers of attorney,
indemnities, underwriting agreements, lock-up letters and other documents
required under the terms of such approved underwriting arrangements, and (c) if
such Holder is not then an Electing Holder, such Holder returns a completed and
signed Notice and Questionnaire to the Company in accordance with Section
3(a)(ii) hereof within a reasonable amount of time before such underwritten
offering. The Holders participating in any underwritten offering shall be
responsible for any underwriting discounts and commissions and fees and, subject
to Section 4 hereof, expenses of their own counsel. The Company and Shire shall
pay all expenses customarily borne by issuers in an underwritten offering,
including but not limited to filing fees, the fees and disbursements of their
counsel and independent public accountants and any printing expenses incurred in
connection with such underwritten offering. Notwithstanding any of the foregoing
or the provisions of Section 3(n) hereof, upon receipt of a request from the

                                       16
<PAGE>

managing Underwriters or a representative of holders of a majority of the
Registrable Securities to be included in an underwritten offering to prepare and
file an amendment or supplement to the Shelf Registration Statement and
Prospectus in connection with an underwritten offering, the Company and Shire
may delay the filing of any such amendment or supplement for up to 90 day if
Shire possesses material non-public information (i), the disclosure of which
would have a material adverse effect on Shire and its subsidiaries taken as a
whole, or (ii) relating to a previously undisclosed proposed or pending
transaction and, in Shire's reasonable belief, its disclosure would impede
Shire's ability to consummate such transaction. The Company's and Shire's
obligations under this Section 6 shall be joint and several.

     7. Liquidated Damages.

     (a) Pursuant to Section 2(a) hereof, Shire may, upon written notice to all
the Holders, postpone having the Shelf Registration Statement declared effective
for a reasonable period not to exceed 90 days if it possesses material
non-public information, the disclosure of which would have a material adverse
effect on Shire and its subsidiaries taken as a whole. Notwithstanding any such
postponement, if (i) on or prior to the 90th day following the Closing Date, a
Shelf Registration Statement has not been filed with the Commission or (ii) on
or prior to the 180th day following the Closing Date, such Shelf Registration
Statement is not declared effective by the Commission (each, a "Registration
Default"), the Company and Shire shall be required to pay liquidated damages
("Liquidated Damages"), from and including the day following such Registration
Default until such Shelf Registration Statement is either so filed or so filed
and subsequently declared effective, as applicable, at a rate per annum equal to
an additional one-quarter of one percent (0.25%) of the principal amount of
Registrable Securities, to and including the 90th day following such
Registration Default and one-half of one percent (0.5%) thereof from and after
the 91st day following such Registration Default.

     (b) In the event that the Shelf Registration Statement ceases to be
effective (or the Holders of Registrable Securities are otherwise prevented or
restricted by the Company or Shire from effecting sales pursuant thereto) (an
"Effective Failure") for more than 45 days or, if Shire has received the prior
written consent of the Representatives pursuant to Section 2(c), 60 days,
whether or not consecutive, in any 90-day period, or for more than 90 days,
whether or not consecutive, during any 12-month period, then the Company and
Shire shall pay Liquidated Damages at a rate per annum equal to an additional
one-half of one percent (0.5%) of the principal amount of Registrable Securities
from the 46th day or 61st day, respectively, of the applicable 90-day period or
the 91st day of the applicable 12-month period, as the case may be, that such
Shelf Registration Statement ceases to be effective (or the Holders of
Registrable Securities are otherwise prevented or restricted by the Company or
Shire from effecting sales pursuant thereto) until the earlier of (i) the time
the Shelf Registration Statement again becomes effective or the Holders of
Registrable Securities are again able to make sales under the Shelf Registration
Statement or (2) the time the Effectiveness Period expires. For the purpose of

                                       17
<PAGE>

determining an Effective Failure, days on which the Company and Shire have been
obligated to pay Liquidated Damages in accordance with the foregoing in respect
of a prior Effective Failure within the applicable 90-day or 12-month period, as
the case may be, shall not be included.

     (c) In the event the Company and Shire fail to file a post-effective
amendment to the Shelf Registration Statement, or the post-effective amendment
is not declared effective, within the periods required by Section 3, the Company
and Shire shall pay Liquidated Damages at a rate per annum equal to an
additional one-half of one percent (0.5%) of the principal amount of Registrable
Securities from and including the date of such Registration Default until such
time as such Registration Default is cured.

     (d) Any amounts to be paid as Liquidated Damages pursuant to paragraph (a),
(b) or (c) of this Section 7 shall be paid semi-annually in arrears, with the
first semi-annual payment due on the first Interest Payment Date (as defined in
the Indenture), as applicable, following the date of such Registration Default.
Such Liquidated Damages will accrue (1) in respect of the Securities at the
rates set forth in paragraph (a), (b) or (c) of this Section 7, as applicable,
on the principal amount of the Securities and (2) in respect of the Ordinary
Shares issued in exchange for Preference Shares, at the rates set forth in
paragraph (a), (b) or (c) of this Section 7, as applicable, applied to the
Exchange Price (as defined in the Restated Memorandum and Articles of
Association of the Company) at that time.

     (e) Except as provided in Section 8(b) hereof, the Liquidated Damages as
set forth in this Section 7 shall be the exclusive monetary remedy available to
the Holders of Registrable Securities for such Registration Default or Effective
Failure. In no event shall the Company and Shire in the aggregate be required to
pay Liquidated Damages in excess of one-half of one percent (0.5%) per annum,
regardless of whether one or multiple Registration Defaults exist. The Company's
and Shire's liability under this Section 7 shall be joint and several.

     8. Miscellaneous.

     (a) Other Registration Rights. Shire may grant registration rights that
would permit any person that is a third party the right to piggy-back on any
Shelf Registration Statement, provided that if the Managing Underwriter of any
underwritten offering conducted pursuant to Section 6 hereof notifies Shire and
the Electing Holders that the total amount of securities which the Electing
Holders and the holders of such piggy-back rights intend to include in any Shelf
Registration Statement is so large as to materially threaten the success of such
offering (including the price at which such securities can be sold), then the
amount, number or kind of securities to be offered for the account of holders of
such piggy-back rights will be reduced to the extent necessary to reduce the
total amount of securities to be included in such offering to the amount, number
and kind recommended by the Managing Underwriter prior to any reduction in the
amount of Registrable Securities to be included in such Shelf Registration
Statement.

                                       18
<PAGE>

     (b) Specific Performance. The parties hereto acknowledge that there would
be no adequate remedy at law if the Company or Shire fails to perform any of its
obligations hereunder and that the Purchasers and the Holders from time to time
may be irreparably harmed by any such failure, and accordingly agree that the
Purchasers and such Holders, in addition to any other remedy to which they may
be entitled at law or in equity and without limiting the remedies available to
the Electing Holders under Section 7 hereof, shall be entitled to compel
specific performance of the obligations of the Company or Shire, respectively,
under this Registration Rights Agreement in accordance with the terms and
conditions of this Registration Rights Agreement, in any court of the United
States or any State thereof having jurisdiction.

     (c) Amendments and Waivers. This Agreement, including this Section 8(c),
may be amended, and waivers or consents to departures from the provisions hereof
may be given, only by a written instrument duly executed by the Company, Shire
and the holders of a majority in aggregate principal amount of Registrable
Securities then outstanding. Each Holder of Registrable Securities outstanding
at the time of any such amendment, waiver or consent or thereafter shall be
bound by any amendment, waiver or consent effected pursuant to this Section
8(c), whether or not any notice, writing or marking indicating such amendment,
waiver or consent appears on the Registrable Securities or is delivered to such
Holder.

     (d) Notices. All notices and other communications provided for or permitted
hereunder shall be given as provided in the Indenture.

     (e) Parties in Interest. The parties to this Agreement intend that all
Holders of Registrable Securities shall be entitled to receive the benefits of
this Agreement and that any Electing Holder shall be bound by the terms and
provisions of this Agreement by reason of such election with respect to the
Registrable Securities which are included in a Shelf Registration Statement. All
the terms and provisions of this Agreement shall be binding upon, shall inure to
the benefit of and shall be enforceable by the respective successors and assigns
of the parties hereto and any Holder from time to time of the Registrable
Securities to the aforesaid extent. In the event that any transferee of any
Holder of Registrable Securities shall acquire Registrable Securities, in any
manner, whether by gift, bequest, purchase, operation of law or otherwise, such
transferee shall, without any further writing or action of any kind, be entitled
to receive the benefits of and, if an Electing Holder, be conclusively deemed to
have agreed to be bound by and to perform all of the terms and provisions of
this Agreement to the aforesaid extent.

     (f) Counterparts. This Agreement may be executed in any number of
counterparts and by the parties hereto in separate counterparts, each of which
when so executed shall be deemed to be an original and all of which taken
together shall constitute one and the same agreement.

                                       19
<PAGE>

     (g) Headings. The headings in this Agreement are for convenience of
reference only and shall not limit or otherwise affect the meaning hereof.

     (h) Governing Law. This Agreement shall be governed by and construed in
accordance with the laws of the State of New York.

     (i) Severability. In the event that any one or more of the provisions
contained herein, or the application thereof in any circumstances, is held
invalid, illegal or unenforceable in any respect for any reason, the validity,
legality and enforceability of any such provision in every other respect and of
the remaining provisions hereof shall not be in any way impaired or affected
thereby, it being intended that all of the rights and privileges of the parties
hereto shall be enforceable to the fullest extent permitted by law.

     (j) Survival. The respective indemnities, agreements, representations,
warranties and other provisions set forth in this Agreement or made pursuant
hereto shall remain in full force and effect, regardless of any investigation
(or any statement as to the results thereof) made by or on behalf of any
Electing Holder, any director, officer or partner of such Holder, any agent or
underwriter, any director, officer or partner of such agent or underwriter, or
any controlling person of any of the foregoing, and shall survive the transfer
and registration of the Registrable Securities of such Holder.

                                       20
<PAGE>

     Please confirm that the foregoing correctly sets forth the agreement
between the Company and you.

                              Very truly yours,

                              Shire Finance Limited

                              By:    /s/ Rolf Stahel
                                     ------------------------------------------
                                     Name: Rolf Stahel
                                     Title: Director

                              Shire Pharmaceuticals Group plc

                              By:    /s/ Rolf Stahel
                                     -----------------------------------------
                                     Name: Rolf Stahel
                                     Title: Chief Executive

Accepted as of the date hereof:

Bear, Stearns International Limited

By:/s/ Stephen Parish
   ------------------------------------

Goldman Sachs International

By:  /s/ Eoghainn Calder
     ----------------------------------

                                       21
<PAGE>

                                                                      Appendix A

                              Shire Finance Limited
                         Shire Pharmaceuticals Group plc

                         INSTRUCTION TO DTC PARTICIPANTS

                                (Date of Mailing)

                     URGENT - IMMEDIATE ATTENTION REQUESTED

                          DEADLINE FOR RESPONSE: [DATE]

     The Depository Trust Company ("DTC") has identified you as a DTC
Participant through which beneficial interests in the 2% Senior Guaranteed
Convertible Notes due 2011 (the "Securities") of Shire Finance Limited (the
"Company") guaranteed by Shire Pharmaceuticals Group plc ("Shire") are held.

     The Company and Shire are in the process of registering the Securities
under the Securities Act of 1933 for resale by the beneficial owners thereof. In
order to have their Securities included in the registration statement,
beneficial owners must complete and return the enclosed Notice of Registration
Statement and Selling Securityholder Questionnaire.

     It is important that beneficial owners of the Securities receive a copy of
the enclosed materials as soon as possible as their rights to have the
Securities included in the registration statement depend upon their returning
the Notice and Questionnaire by [Deadline for response]. Please forward a copy
of the enclosed documents to each beneficial owner that holds interests in the
Securities through you. If you require more copies of the enclosed materials or
have any questions pertaining to this matter, please contact the Company
Secretary, c/o Hampshire International Business Park, Chineham, Basingstoke,
Hampshire RG24 8EP, telephone: +44 1256 894 000.

                                       A-1
<PAGE>

                              Shire Finance Limited

                        Notice of Registration Statement
                                       and
                      Selling Securityholder Questionnaire

                                     [Date]

     Shire Finance Limited (the "Company") and Shire Pharmaceuticals Group plc
("Shire") have filed with the United States Securities and Exchange Commission
(the "Commission") a registration statement on Form F-3 (the "Shelf Registration
Statement") for the registration and resale under Rule 415 of the United States
Securities Act of 1933, as amended (the "Securities Act"), of the Company's 2%
Senior Guaranteed Convertible Notes due 2011 (the "Securities") convertible into
exchangeable redeemable preference shares of the Company (the "Preference
Shares") and the Ordinary Shares of Shire, par value $___ per share (the
"Ordinary Shares"), issuable in exchange therefore, in accordance with the
Registration Rights Agreement, dated as of August 21, 2001 (the "Registration
Rights Agreement"), among Shire, the Company and the purchasers named therein.
The Ordinary Shares will be issued in the form of ordinary shares or American
Depositary Shares ("ADSs"). A copy of the Registration Rights Agreement is
attached hereto. All capitalized terms not otherwise defined herein shall have
the meanings ascribed thereto in the Registration Rights Agreement.

     In order to have Registrable Securities included in the Shelf Registration
Statement (or a supplement or amendment thereto), this Notice of Registration
Statement and Selling Securityholder Questionnaire ("Notice and Questionnaire")
must be completed, executed and delivered to the Company at the address set
forth herein for receipt ON OR BEFORE [DEADLINE FOR RESPONSE]. Beneficial owners
of Registrable Securities who do not complete, execute and return this Notice
and Questionnaire by such date (i) will not be named as selling securityholders
in the Shelf Registration Statement and (ii) may not use the Prospectus forming
a part thereof for resales of Registrable Securities.

     Certain legal consequences arise from being named as a selling
securityholder in the Shelf Registration Statement and related Prospectus.
Accordingly, holders and beneficial owners of Registrable Securities are advised
to consult their own securities law counsel regarding the consequences of being
named or not being named as a selling securityholder in the Shelf Registration
Statement and related Prospectus.

                                      1
<PAGE>

     The term "Registrable Securities" is defined in the Registration Rights
Agreement to mean all or any portion of the Securities issued from time to time
under the Indenture in registered form and the Ordinary Shares (including the
Ordinary Shares underlying the ADSs) issuable in exchange for Preference Shares;
provided, however, that a security ceases to be a Registrable Security when it
is no longer a Restricted Security.

     The term "Restricted Security" is defined in the Registration Rights
Agreement to mean any Security or Ordinary Share issuable in exchange for
Preference Shares except any such Security or Ordinary Share which (i) has been
effectively registered under the Securities Act and sold in a manner
contemplated by the Shelf Registration Statement, (ii) has been transferred in
compliance with Rule 144 under the Securities Act (or any successor provision
thereto) or is transferable pursuant to paragraph (k) of such Rule 144 (or any
successor provision thereto) by a non-Affiliate, or (iii) has otherwise been
transferred and a new Security or Ordinary Share not subject to transfer
restrictions under the Securities Act has been delivered by or on behalf of the
Company in accordance with Section 3.5 of the Indenture.

                                    ELECTION

     The undersigned holder (the "Selling Securityholder") of Registrable
Securities hereby elects to include in the Shelf Registration Statement the
Registrable Securities beneficially owned by it and listed below in Item (3).
The undersigned, by signing and returning this Notice and Questionnaire, agrees
to be bound with respect to such Registrable Securities by the terms and
conditions of this Notice and Questionnaire and the Registration Rights
Agreement, including, without limitation, Section 5 of the Registration Rights
Agreement, as if the undersigned Selling Securityholder were an original party
thereto.

     Upon any sale of Registrable Securities pursuant to the Shelf Registration
Statement, the Selling Securityholder will be required to deliver to the Company
and the Trustee the Notice of Transfer (completed and signed) set forth in
Exhibit 1 to this Notice and Questionnaire.

     The Selling Securityholder hereby provides the following information to the
Company and represents and warrants that such information is accurate and
complete:

                                      2
<PAGE>

                                  QUESTIONNAIRE

(1)  (a)Full Legal Name of Selling Securityholder:

      _______________________________________________________________________
     (b)Full Legal Name of Registered Holder (if not the same as in (a) above)
        of Registrable Securities Listed in Item (3) Below:

      ________________________________________________________________________
     (c)Full Legal Name of DTC Participant (if applicable and if not the
        same as (b) above) Through Which Registrable Securities Listed in
        Item (3) Below are Held:

      ________________________________________________________________________

(2)        Address for Notices to Selling Securityholder:

                                ---------------------------------------
                                ---------------------------------------
                                ---------------------------------------

           Telephone:
                                ---------------------------------------
           Fax:
                                ---------------------------------------
           Contact Person:
                                ---------------------------------------

(3)        Beneficial Ownership of Securities:

          Except as set forth below in this Item (3), the undersigned Selling
          Securityholder does not beneficially own any Securities or Ordinary
          Shares issued upon conversion, repurchase or redemption of any
          Securities.

     (a)  Principal amount of Registrable Securities (as defined in the
          Registration Rights Agreement) beneficially owned:____________________
          CUSIP No(s). of such Registrable Securities:__________________________

           Number of Ordinary Shares (if any) issued upon conversion, repurchase
            or redemption of Registrable Securities:____________________________

     (b)  Principal amount of Securities other than Registrable Securities
          beneficially owned:

            CUSIP No(s). of such other Securities:______________________________

          Number of Ordinary Shares (if any) issued upon conversion of such
          other Securities:_____________________________________________________

     (c)  Principal amount of Registrable Securities which the undersigned
          wishes to be included in the Shelf Registration Statement:____________

                                       3
<PAGE>
          CUSIP No(s). of such Registrable Securities to be included in the
          Shelf Registration Statement:_________________________________________

          Number of Ordinary Shares (if any) issued upon conversion of
          Registrable Securities which are to be included in the Shelf
          Registration Statement:_______________________________________________

(4)  Beneficial Ownership of Other Securities of the Company:

          Except as set forth below in this Item (4), the undersigned Selling
          Securityholder is not the beneficial or registered owner of any
          Ordinary Shares or any other securities of the Company, other than the
          Securities and Ordinary Shares listed above in Item (3).

          State any exceptions here:

(5)  Relationships with the Company:

          Except as set forth below, neither the Selling Securityholder nor any
          of its affiliates, officers, directors or principal equity holders (5%
          or more) has held any position or office or has had any other material
          relationship with the Company (or its predecessors or affiliates)
          during the past three years.

          State any exceptions here:

(6)  Plan of Distribution:

          Except as set forth below, the undersigned Selling Securityholder
          intends to distribute the Registrable Securities listed above in Item
          (3) only as follows (if at all): Such Registrable Securities may be
          sold from time to time directly by the undersigned Selling
          Securityholder or, alternatively, through underwriters, broker-dealers
          or agents. Such Registrable Securities may be sold in one or more
          transactions at fixed prices, at prevailing market prices at the time
          of sale, at varying prices determined at the time of sale, or at
          negotiated prices. Such sales may be effected in transactions (which
          may involve crosses or block transactions) (i) on any national
          securities exchange or quotation service on which the Registrable
          Securities may be listed or quoted at the time of sale, (ii) in the
          over-the-counter market, (iii) in transactions otherwise than on such
          exchanges or services or in the over-the-counter market, or (iv)
          through the writing of options. In connection with sales of the
          Registrable Securities or otherwise, the Selling Securityholder may
          enter into hedging transactions with broker-dealers, which may in turn
          engage in short sales of the Registrable Securities in the course of
          hedging the positions they assume. The Selling Securityholder may also
          sell Registrable Securities short and deliver Registrable Securities
          to close out such short

                                        4
<PAGE>

          positions, or loan or pledge Registrable Securities to broker-dealers
          that in turn may sell such securities.

          State any exceptions here:

     Note: In no event may such method(s) of distribution take the form of an
underwritten offering of the Registrable Securities without the prior agreement
of the Company.

     By signing below, the Selling Securityholder acknowledges that it
understands its obligation to comply, and agrees that it will comply, with the
prospectus delivery and other provisions of the Securities Act and the Exchange
Act and the rules and regulations thereunder, particularly Regulation M.

     In the event that the Selling Securityholder transfers all or any portion
of the Registrable Securities listed in Item (3) above after the date on which
such information is provided to the Company, the Selling Securityholder agrees
to notify the transferee(s) at the time of the transfer of its rights and
obligations under this Notice and Questionnaire and the Registration Rights
Agreement.

     By signing below, the Selling Securityholder consents to the disclosure of
the information contained herein in its answers to Items (1) through (6) above
and the inclusion of such information in the Shelf Registration Statement and
related Prospectus. The Selling Securityholder understands that such information
will be relied upon by the Company in connection with the preparation of the
Shelf Registration Statement and related Prospectus.

     In accordance with the Selling Securityholder's obligation under Section
3(a) of the Registration Rights Agreement to provide such information as may be
required by law for inclusion in the Shelf Registration Statement, the Selling
Securityholder agrees to promptly notify the Company of any inaccuracies or
changes in the information provided herein which may occur subsequent to the
date hereof at any time while the Shelf Registration Statement remains in
effect. All notices hereunder and pursuant to the Registration Rights Agreement
shall be made in writing, by hand-delivery, first-class mail or air courier
guaranteeing overnight delivery as follows:

           (i) To the Company:      Shire Finance Limited
                                    c/o Maples and Calder
                                    Ugland House
                                    P.O. Box 309
                                    George Town
                                    Grand Cayman, Cayman Islands
                                    Attn: Directors/F.O.E.

                                       5
<PAGE>

           (ii) With a copy to:     Shire Pharmaceuticals Group plc
                                    Hampshire International Business Park
                                    Chineham, Basingstoke
                                    Hampshire RG24 8EP
                                    England
                                    Attn: Company Secretary

           (iii) And a copy to:     Cahill Gordon & Reindel
                                    80 Pine Street
                                    New York, NY 10005
                                    U.S.A.
                                    Attn: John Mitchell

     Once this Notice and Questionnaire is executed by the Selling
Securityholder and received by the Company, the terms of this Notice and
Questionnaire, and the representations and warranties contained herein, shall be
binding on, shall inure to the benefit of and shall be enforceable by the
respective successors, heirs, personal representatives, and assigns of the
Company and the Selling Securityholder (with respect to the Registrable
Securities beneficially owned by such Selling Securityholder and listed in Item
(3) above). This Agreement shall be governed in all respects by the laws of the
State of New York.

                                       6
<PAGE>

     IN WITNESS WHEREOF, the undersigned, by authority duly given, has caused
this Notice and Questionnaire to be executed and delivered either in person or
by its duly authorized agent.

Dated:
        ----------------------------

                  --------------------------------------------------------------
                  Selling Securityholder
                  (Print/type full legal name of beneficial owner of Registrable
                   Securities)

                  By:
                       ---------------------------------------------------------
                  Name:
                  Title:

PLEASE RETURN THE COMPLETED AND EXECUTED NOTICE AND QUESTIONNAIRE FOR RECEIPT ON
OR BEFORE [DEADLINE FOR RESPONSE] TO THE COMPANY AT:

                                      Shire Finance Limited
                                      c/o Maples and Calder
                                      Ugland House
                                      P.O. Box 309
                                      George Town
                                      Grand Cayman, Cayman Islands
                                      Attention: Directors/F.O.E.

                                      WITH A COPY TO:

                                      Cahill Gordon & Reindel
                                      80 Pine Street
                                      New York, NY 10005
                                      U.S.A.
                                      Attn: John Mitchell

                                       7
<PAGE>

                                                                       Exhibit I
                                                                   to Appendix A

              NOTICE OF TRANSFER PURSUANT TO REGISTRATION STATEMENT

Shire Finance Limited
c/o Maples and Calder
Ugland House
P.O. Box 309
George Town
Grand Cayman, Cayman Islands
Attention: Directors/F.O.E.

Shire Pharmaceuticals Group plc
Hampshire International Business Park
Chineham
Basingstoke, Hampshire
England RG24 8EP
Attention:  Company Secretary

Cahill Gordon & Reindel
80 Pine Street
New York, NY 10005 U.S.A.
Attention: John Mitchell

The Bank of New York
One Canada Square
London
England E14 5AL
Attention:  Sunjeeve D. Patel

               Re: 2% Senior Guaranteed Convertible Notes due 2011
                   (the "Notes") Convertible into Preference
                   Shares of Shire Finance Limited (the "Company")

Dear Sirs:

     Please be advised that _____________________ has transferred $___________
aggregate principal amount of the above-referenced Notes or Ordinary Shares of
Shire Pharmaceuticals Group plc ("Shire") issued in exchange for Preference
Shares, pursuant to an effective Registration Statement on Form F-3 (File No.
333-____) filed by the Company and Shire.

     We hereby certify that the prospectus delivery requirements, if any, of the
Securities Act of 1933, as amended, have been satisfied with respect to the
transfer described above and that the above-named beneficial owner of the Notes
or Ordinary Shares is named as a selling securityholder in the Prospectus dated
[date], or in amendments or supplements thereto, and that the aggregate
principal amount of the Notes or number of Ordinary Shares transferred are [a
portion of] the Notes or Ordinary Shares listed in such Prospectus as amended or
supplemented opposite such owner's name.

                                       I-1
<PAGE>

Dated:

                                                Very truly yours,

                                                ------------------------
                                                (Name)

                                           By:  ________________________
                                                (Authorized Signature)

                                      I-2SHIRE FINANCE LIMITED

                 2% Senior Guaranteed Convertible Notes Due 2011

                                  Guaranteed by

                         SHIRE PHARMACEUTICALS GROUP PLC

                               Purchase Agreement

                                                                 August 15, 2001
Bear, Stearns International Limited
Goldman Sachs International,
As representatives of the several Purchasers
     named in Schedule I hereto (the "Representatives"),
c/o Bear, Stearns International Limited
One Canada Square
London E14 5AD
England

Ladies and Gentlemen:

     Shire Finance Limited, an exempted limited company organized under the laws
of the Cayman Islands (the "Company"), proposes, subject to the terms and
conditions stated herein, to issue to subscribers procured by the Purchasers
named in Schedule I hereto (the "Purchasers") or, failing which, to the
Purchasers an aggregate of $350,000,000 principal amount of the 2% Senior
Guaranteed Convertible Notes due 2011 (the "Firm Securities") and, at the
election of the Purchasers, up to an aggregate of $50,000,000 additional
aggregate principal amount thereof (the "Optional Securities") (the Firm
Securities and the Optional Securities are herein collectively called the
"Securities"). The Securities, which are guaranteed by Shire Pharmaceuticals
Group plc, a public limited liability company organized under the laws of
England and Wales ("Shire"), will be convertible into exchangeable redeemable
preference shares of the Company (the "Preference Shares") and then will be
exchanged for ordinary shares of the capital stock of Shire in the form of
ordinary shares or American Depositary Shares (the "ADSs") or, at the option of
Shire, cash. Payments of dividends and liquidation preferences on the Preference
Shares will be guaranteed by Shire pursuant to a guarantee agreement between
Shire and The Bank of New York (the "Guarantee"). The ADSs are to be issued
pursuant to a deposit agreement (the "Deposit Agreement"), dated as of March 20,
1998, as amended, among Shire, Morgan Guaranty Trust Company of New York, as
depositary (the "Depositary"), and holders from time to time of the American
Depositary Receipts (the "ADRs") issued by the Depositary and evidencing the
ADSs. The Securities, the ordinary shares and the ordinary shares underlying the
ADSs will

<PAGE>

have the benefit of a Registration Rights Agreement to be dated as of
August 21, 2001, among Shire, the Company and the Purchasers (the "Registration
Rights Agreement").

     1. The Company and Shire jointly and severally represent and warrant to,
and agree with, each of the Purchasers that:

          (a) An offering circular (the "Offering Circular") has been prepared
     in connection with the offering of the Securities, the Preference Shares
     issuable upon conversion thereof and the ordinary shares and ADSs issuable
     upon exchange of the Preference Shares. Any reference to the Offering
     Circular shall be deemed to refer to and include (i) Shire's Annual Report
     on Form 10-K for the fiscal year ended December 31, 2000, Quarterly Reports
     on Form 10-Q for the quarters ended March 31 and June 30, 2001, Proxy
     Statement for the Extraordinary General Meeting of Shareholders filed on
     March 1, 2001, Proxy Statement for the 2000 Annual Meeting of Shareholders
     filed on April 30, 2001 and Current Reports on Form 8-K filed on May 4, May
     11, July 17, July 23, as amended, and July 25 and any other Current Reports
     which are incorporated therein); (ii) BioChem Pharma Inc.'s annual report
     on Form 20-F for the year ended December 31, 1999, current reports on Form
     6-K filed on January 10, January 26, February 15, March 6, March 9, March
     15, April 3, April 11, April 20, April 27, April 28, May 1, May 24, June
     19, June 27, July 11, July 18, July 26, August 4, August 28, September 22,
     October 26, November 1, November 15, November 20, December 1, December 11,
     December 13, December 18, December 22 and December 31, 2000, and current
     reports on Form 6-K filed on January 10, January 26, February 1, February
     6, March 1, March 28, March 30 and April 5, 2001; and (iii) any other
     documents filed with or furnished to the United States Securities and
     Exchange Commission (the "Commission") pursuant to Section 13(a), 13(c) or
     15(d) of the United States Securities Exchange Act of 1934, as amended (the
     "Exchange Act") on or prior to the date of the Offering Circular and
     expressly incorporated by reference therein, and any reference to the
     Offering Circular as amended or supplemented as of any specified date shall
     be deemed to include any documents filed with or furnished to the
     Commission pursuant to Section 13(a), 13(c) or 15(d) of the Exchange Act
     after the date of the Offering Circular and prior to such specified date;
     and all documents filed or furnished under the Exchange Act and so deemed
     to be included in the Offering Circular or any amendment or supplement
     thereto are hereinafter called the "Exchange Act Reports." The Exchange Act
     Reports, when they were or are filed with or furnished to the Commission,
     conformed or will conform in all material respects to the applicable
     requirements of the Exchange Act and the applicable rules and regulations
     of the Commission thereunder. The Offering Circular and any amendments or
     supplements thereto and the Exchange Act Reports did not and will not, as
     of their respective dates, contain an untrue statement of a material fact
     or omit to state a material fact necessary in order to make the statements
     therein, in the light of the circumstances under which they were made, not
     misleading; provided, however, that this representation and warranty shall
     not apply to any statements or omissions made in reliance upon and in
     conformity with information furnished in writing to the Company by a
     Purchaser through the Representatives expressly for use therein;

                                       2
<PAGE>

          (b) If Securities are listed on the London Stock Exchange, (i) the
     Listing Particulars to be prepared by the Company and Shire relating to the
     Securities (the "Listing Particulars"), when published, will contain all
     particulars and information required by, and will comply with, the
     Companies Act 1985 of Great Britain (the "Companies Act"), the Financial
     Services Act 1986 of the United Kingdom (the "FSA"), the listing rules made
     by the United Kingdom Listing Authority (the "UKLA") pursuant to Part IV of
     the FSA (the "Listing Rules") and, so far as the Company and Shire are
     aware (having not made inquiries other than in respect of matters relating
     to the United Kingdom), all other relevant statutes and regulations and
     (ii) having regard to the particular nature of the Company, Shire and each
     of Shire's subsidiaries and Shire's and the Company's share capital and the
     other matters referred to in Sections 146(2) and (3) of the FSA (other
     than, in the case of the Offering Circular, the information required by
     Section 146(3)(d) of the FSA), the Offering Circular contains and the
     Listing Particulars will contain all such information as investors and
     their professional advisers would reasonably require, and reasonably expect
     to find there, for the purposes of making an informed assessment of the
     assets and liabilities, financial position, profits and losses, and
     prospects of the Company, Shire and Shire's subsidiaries, and of the rights
     attached to the Securities, the Preference Shares and the ordinary shares;

          (c) If an application is made for the Securities to be admitted to the
     Official List of the UKLA, all statements made in writing by or on behalf
     of the Company or Shire in connection with any application to the UKLA for
     certain information to be omitted from the Listing Particulars will be true
     and accurate in all material respects and will not be materially
     misleading, and there are no material facts which will not be disclosed to
     the UKLA in connection therewith which by their omission would make any
     such statements misleading in any material respect or which would be
     material for disclosure to the UKLA, and there are no matters other than
     those that will be disclosed in the Listing Particulars or otherwise
     disclosed in writing to the UKLA that should be taken into account by the
     UKLA in considering the suitability for listing of the Securities or the
     ordinary shares;

          (d) If an application is made to list the Securities on the Luxembourg
     Stock Exchange, the Offering Circular, as may be supplemented for the
     purpose of such application, will contain all information required by and
     will comply with all relevant requirements of the Luxembourg Stock
     Exchange; and such application will be made in accordance with all
     applicable requirements;

          (e) Neither Shire nor any of its subsidiaries has sustained since the
     date of the latest audited financial statements included or incorporated by
     reference in the Offering Circular any material loss or interference with
     its business from fire, explosion, flood or other calamity, whether or not
     covered by insurance, or from any labor dispute or court or governmental
     action, order or decree, otherwise than as set forth or contemplated in the
     Offering Circular; and, since the respective dates as of which information
     is given or incorporated by reference in the Offering Circular, there has
     not been any material change in the capital stock (other than pursuant to
     the exercise of outstanding options, the exchange of Exchangeable Shares of
     Shire Acquisition Inc., the

                                       3
<PAGE>

     conversion of Shire's unsecured convertible zero coupon loan note due to
     Arenol Corporation and the exchange of any remaining shares of Roberts
     Pharmaceutical Corporation) or long-term debt of Shire or any of its
     subsidiaries or any material adverse change, or any development involving a
     prospective material adverse change, in or affecting the general affairs,
     management, financial position, shareholders' equity or results of
     operations of Shire and its subsidiaries, otherwise than as set forth or
     contemplated in the Offering Circular;

          (f) Shire and its subsidiaries have good and marketable title in fee
     simple to all real property of which they hold the freehold interest and
     good and marketable title to all material personal property owned by them,
     in each case free and clear of all liens, encumbrances and defects except
     such as are described in the Offering Circular or such as do not materially
     affect the value of such property and do not interfere with the use made
     and proposed to be made of such property by Shire and its subsidiaries; and
     any material real property and buildings held under lease by Shire and its
     subsidiaries are held by them under valid, subsisting and enforceable
     leases with such exceptions as are not material and do not interfere with
     the use made and proposed to be made of such property and buildings by
     Shire and its subsidiaries;

          (g) Shire has been duly incorporated and is validly existing as a
     public limited liability company under the laws of England and Wales, with
     power and authority to own its properties and conduct its business as
     described in the Offering Circular, and has been duly qualified as a
     foreign corporation for the transaction of business and is in good standing
     (to the extent such concept exists) under the laws of each other
     jurisdiction in which it owns or leases properties or conducts any business
     so as to require such qualification, or is subject to no material liability
     or disability by reason of the failure to be so qualified in any such
     jurisdiction; and each subsidiary of Shire, including the Company, has been
     duly organized and is validly existing in good standing (to the extent such
     concept exists) under the laws of its jurisdiction of organization; and the
     Company has power and authority to own its properties and conduct its
     business as described in the Offering Circular, and has been duly qualified
     as a foreign corporation for the transaction of business and is in good
     standing (to the extent such concept exists) under the laws of each other
     jurisdiction in which it owns or leases properties or conducts any business
     so as to require such qualification, or is subject to no material liability
     or disability by reason of the failure to be so qualified in any such
     jurisdiction;

          (h) Each of the Company and Shire has an authorized capitalization as
     set forth in the Offering Circular, and all of the issued shares in the
     capital of the Company and Shire have been duly and validly authorized and
     issued and are fully paid and non-assessable; the holders of outstanding
     shares in the capital of Shire are not entitled to preemptive or other
     rights to acquire the ordinary shares or the ADSs which have not been
     complied with or waived; there are no outstanding securities convertible
     into or exchangeable for, or warrants, rights or options to purchase from
     Shire, or obligations of Shire to issue, ordinary shares or any other class
     of share capital of Shire or shares in the capital of any subsidiary of
     Shire, other than the outstanding options pursuant to employee share
     schemes described in the Offering Circular, the

                                       4
<PAGE>

     Exchangeable Shares of Shire Acquisition Inc., Shire's unsecured
     convertible zero coupon loan note due to Arenol Corporation and any
     remaining shares of Roberts Pharmaceutical Corporation; the Preference
     Shares issuable upon conversion of the Securities, when duly and validly
     authorized, issued and delivered in accordance with the provisions of the
     Securities and the Indenture referred to below, will be duly and validly
     issued, fully paid and non-assessable and will conform to the description
     of the Preference Shares contained in the Offering Circular; the ordinary
     shares of Shire issuable upon exchange of the Preference Shares have been
     duly and validly authorized and reserved for issuance and, when issued in
     accordance with the provisions of the Indenture referred to below, will be
     duly and validly issued, fully paid and non-assessable and will conform to
     the description of the ordinary shares contained in the Offering Circular
     and may be freely deposited by or on behalf of Shire with the Depositary
     against issuance of ADRs evidencing ADSs;

          (i) The Securities have been duly authorized and, when issued and
     delivered pursuant to this Agreement, will have been duly executed,
     authenticated, issued and delivered and will constitute valid and legally
     binding obligations of the Company entitled to the benefits provided by the
     Indenture to be dated as of August 21, 2001 (the "Indenture") among the
     Company, Shire and The Bank of New York, as Trustee (the "Trustee"), under
     which they are to be issued; each of the Indenture and the Registration
     Rights Agreement has been duly authorized by the Company and Shire and,
     when executed and delivered by the parties thereto, will constitute valid
     and legally binding obligations of the Company and Shire, enforceable in
     accordance with its terms, subject, as to enforcement, to bankruptcy,
     insolvency, reorganization and other laws of general applicability relating
     to or affecting creditors' rights and to general equity principles; and the
     Securities, the Indenture and the Registration Rights Agreement will be in
     substantially the form previously delivered to you;

          (j) The Deposit Agreement has been duly authorized, executed and
     delivered by Shire and constitutes a valid and legally binding agreement of
     Shire, enforceable in accordance with its terms, subject, as to
     enforceability, to bankruptcy, insolvency, reorganization and similar laws
     of general applicability relating to or affecting creditors' rights and to
     general equity principles; and upon due issuance by the Depositary of ADRs
     evidencing ADSs and the deposit of ordinary shares in respect thereof in
     accordance with the provisions of the Deposit Agreement, such ADRs will be
     duly and validly issued and the persons in whose names the ADRs are
     registered will be entitled to the rights specified therein and in the
     Deposit Agreement;

          (k) The Guarantee has been duly authorized and, when executed and
     delivered by the parties thereto, will constitute valid and legally binding
     obligations of Shire, enforceable in accordance with its terms, subject to
     bankruptcy, insolvency, reorganization and other laws of general
     applicability relating to or affecting creditors' rights and to general
     equity principles; and the Guarantee will be in substantially the form
     previously delivered to you;

          (l) None of the transactions contemplated by this Agreement
     (including, without limitation, the use of the proceeds from the issue of
     the Securities)

                                       5
<PAGE>

     will violate or result in a violation of Section 7 of the Exchange Act or
     any regulation promulgated thereunder, including, without limitation,
     Regulations T, U, and X of the Board of Governors of the Federal Reserve
     System;

          (m) The issue of the Securities by the Company hereunder, the issuance
     of the Preference Shares by the Company upon conversion of the Securities,
     the issuance of the ordinary shares and the deposit of the ordinary shares
     being deposited with the Depositary against issuance of the ADRs evidencing
     the ADSs, and the compliance by the Company and Shire with all of the
     provisions of the Securities, the Preference Shares, the Indenture, the
     Registration Rights Agreement, the Guarantee, the Deposit Agreement, this
     Agreement and the consummation of the transactions herein and therein
     contemplated will not, subject, in the case of the issuance of the
     Preference Shares, to the adoption by the Company of the Amended and
     Restated Memorandum and Articles of Association incorporating the terms of
     the Preference Shares, conflict with or result in a breach or violation of
     any of the terms or provisions of, or constitute a default under, any
     indenture, mortgage, deed of trust, loan agreement or other agreement or
     instrument to which the Company, Shire or any of Shire's subsidiaries is a
     party or by which the Company, Shire or any of Shire's subsidiaries is
     bound or to which any of the property or assets of the Company, Shire or
     any of Shire's subsidiaries is subject, except for any such conflict,
     breach, violation or default which would not have a current or future
     material adverse affect on the consolidated financial position,
     shareholders' equity, results of operations, earnings, business or
     organizations of Shire and its subsidiaries, taken as a whole (a "Material
     Adverse Effect") nor will such action result in any violation of the
     provisions of the Articles of Association of the Company or Shire or any
     statute or any order, rule or regulation of any court, central bank, stock
     exchange or governmental agency or body in the United States, the United
     Kingdom or the Cayman Islands (each, a "Governmental Agency") having
     jurisdiction over the Company, Shire or any of their properties; and no
     consent, approval, authorization, order, registration or qualification of
     or with any such Governmental Agency (each, a "Governmental Authorization")
     is required for the issue and sale of the Securities, the issue of the
     Preference Shares and the ordinary shares, the deposit of the ordinary
     shares being deposited with the Depositary against issuance of the ADRs
     evidencing the ADSs or the consummation by the Company and Shire of the
     transactions contemplated by this Agreement, the Registration Rights
     Agreement, the Guarantee, the Deposit Agreement or the Indenture, except
     for having the Securities and, subject to notice of issuance, the ordinary
     shares either admitted to the Official List of the UKLA and to trading on
     the London Stock Exchange or listed on the Luxembourg Stock Exchange, as
     the case may be, the filing of a registration statement by the Company and
     Shire with the Commission pursuant to the United States Securities Act of
     1933, as amended (the "Act") in accordance with the Registration Rights
     Agreement and the qualification of the Indenture under the Trust Indenture
     Act of 1939, as amended ("TIA"), and such Governmental Authorizations as
     may be required under state securities or Blue Sky laws in connection with
     the subscription and distribution of the Securities by the Purchasers;

          (n) Neither the Company, Shire nor any of Shire's subsidiaries is in
     violation of its constituent documents or in default in the performance or
     observance

                                       6
<PAGE>

     of any obligation, covenant or condition contained in any indenture,
     mortgage, deed of trust, loan agreement, lease or other agreement or
     instrument to which it is a party or by which it or any of its properties
     may be bound, except for any such default as would not result in a Material
     Adverse Effect;

          (o) The statements set forth in the Offering Circular under the
     captions "Description of Notes," "Description of Preference Shares",
     "Description of Ordinary Shares" and "Description of American Depositary
     Shares and American Depositary Receipts", insofar as they purport to
     constitute a summary of the terms of the Securities, the Indenture, the
     Registration Rights Agreement and the Guarantee; the Preference Shares; the
     ordinary shares; and the Deposit Agreement, the ADSs and the ADRs,
     respectively, and under the captions "Certain Cayman Islands, United
     Kingdom and United States Tax Consequences" and "Plan of Distribution",
     insofar as they purport to describe the provisions of the laws and
     documents referred to therein, are accurate, complete and fair in all
     material respects;

          (p) Other than as set forth or contemplated in the Offering Circular,
     there are no legal or governmental proceedings pending to which Shire, the
     Company or any of Shire's subsidiaries is a party or of which any property
     of Shire, the Company or any of Shire's subsidiaries is the subject that
     are reasonably likely, individually or in the aggregate, to result in a
     Material Adverse Effect; and, to the best of Shire's and the Company's
     knowledge, no such proceedings are threatened or contemplated by
     governmental authorities or threatened by others;

          (q) No Governmental Authorization is required to effect payments of
     principal, premium, if any, and interest on the Securities or dividend
     payments or other distributions on the Preference Shares, the ordinary
     shares or the ADSs;

          (r) All dividend payments or other distributions on the ordinary
     shares and the ADSs may under the current law and regulations of the United
     Kingdom be paid in pounds sterling that may be converted into foreign
     currency that may be freely transferred out of the United Kingdom, and all
     such dividends and other distributions on the ordinary shares and the ADSs
     will not be subject to withholding or other taxes under the laws and
     regulations of the United Kingdom and are otherwise free and clear of any
     other tax, withholding or deduction in the United Kingdom and without the
     necessity of obtaining any Governmental Authorization in the United Kingdom
     (other than, in each case, U.K. tax on income or profits of any Purchaser
     who is resident in the United Kingdom or carries on a trade in the United
     Kingdom through a branch or agency);

          (s) Other than as disclosed in the Offering Circular, no ad valorem
     stamp duty, stamp duty, stamp duty reserve tax or issue, documentary
     certification or other similar tax imposed by any government department or
     other taxing authority whether of or in the United Kingdom, the United
     States or the

                                       7
<PAGE>

     Cayman Islands (each, a "Transfer Tax") and no capital gains, income,
     withholding or other taxes imposed by any such entity whether of or in the
     United Kingdom, the United States or the Cayman Islands is payable in
     connection with (i) the issuance and the delivery by the Company of the
     Securities to or for the respective accounts of the Purchasers or the
     subscribers or purchasers procured by them, (ii) the offering, sale and
     delivery of the Securities by the Purchasers to the initial purchasers,
     (iii) the issuance and delivery of the Preference Shares or the ordinary
     shares or (iv) the deposit with the Depositary or its nominee of the
     ordinary shares by Shire against the issuance of the ADRs evidencing ADSs
     (other than, in each case, U.K. or U.S. tax on income, profits or gains
     from the sale of the Securities, the Preferred Shares or the ordinary
     shares and on the income or capital gains of any person who is resident in
     the United Kingdom or the United States, respectively, or carries on a
     trade in the United Kingdom or the United States, respectively, through a
     branch or agency);

          (t) Shire, the Company and each of Shire's subsidiaries have all
     licenses, franchises, permits, authorizations, approvals and orders and
     other concessions of and from all Governmental Agencies that are necessary
     to own or lease their properties and conduct its businesses as described in
     the Offering Circular, except where the failure to have them would not
     result in a Material Adverse Effect;

          (u) None of Shire, the Company nor any of Shire's subsidiaries have
     taken, directly or indirectly, any action which was designed to or which
     has constituted or which might have been expected to cause or result in
     stabilization or manipulation of the price of any security of Shire or the
     Company in connection with the offering of the Securities;

          (v) When the Securities are issued and delivered pursuant to this
     Agreement, the Securities will not be of the same class (within the meaning
     of Rule 144A under the Act) as securities which are listed on a national
     securities exchange registered under Section 6 of the Exchange Act or
     quoted in a U.S. automated inter-dealer quotation system;

          (w) Shire is subject to Section 13 or 15(d) of the Exchange Act;

          (x) Neither the Company, nor any affiliate of the Company, nor any
     person acting on its or their behalf (other than the Purchasers, as to whom
     no representation or warranty is given) has offered or sold the Securities
     by means of any (i) general solicitation or general advertising within the
     meaning of Rule 502(c) under the Act and (ii) any directed selling efforts
     within the meaning of Rule 902 under the Act, and the Company, any
     affiliate of the Company and any person acting on its or their behalf
     (other than the Purchasers, as to whom no representation or warranty is
     given) has complied with and will implement the "offering restriction"
     within the meaning of such Rule 902;

          (y) Within the preceding six months, neither the Company nor any other
     person acting on behalf of the Company has offered or issued to any person
     any Securities, or any securities of the same or a similar class as the
     Securities, other than Securities offered or issued to the Purchasers
     hereunder. The Company and Shire will take reasonable precautions designed
     to ensure that any offer or issue, direct or indirect, in the United States
     or to any U.S. person (as defined in Rule 902 under the Act) of any

                                       8
<PAGE>

     Securities or any substantially similar security issued by the Company,
     within six months subsequent to the date on which the distribution of the
     Securities has been completed (as notified to the Company by Bear, Stearns
     International Limited), is made under restrictions and other circumstances
     reasonably designed not to affect the status of the offer and sale of the
     Securities in the United States and to U.S. persons contemplated by this
     Agreement as transactions exempt from the registration provisions of the
     Act;

          (z) The Company and Shire are not and, after giving effect to the
     offering and issue of the Securities, will not be an "investment company"
     or an entity "controlled" by an "investment company", as such terms are
     defined in the Investment Company Act of 1940, as amended (the "Investment
     Company Act");

          (aa) Each of Shire and the Company believes it is not a Passive
     Foreign Investment Company ("PFIC") within the meaning of Section 1297 of
     the United States Internal Revenue Code of 1986, as amended, and is not
     likely to become a PFIC;

          (bb) Arthur Andersen, who have certified certain financial statements
     of Shire and its subsidiaries, are independent public accountants as
     required by the Act and the rules and regulations of the Commission
     thereunder;

          (cc) The Company is a "foreign private issuer" (as such term is
     defined in the rules and regulations under the Exchange Act);

          (dd) The audited combined balance sheet, the consolidated profit and
     loss account and the consolidated cash flow statements of Shire and its
     subsidiaries (including the notes thereto) for the years ended December 31,
     1998, 1999 and 2000 and the unaudited combined balance sheet, the
     consolidated profit and loss account and the consolidated cash flow
     statement of Shire and its subsidiaries for the six month period ended June
     30, 2001, included or incorporated by reference in the Offering Circular
     have been prepared with all relevant Statements of Standard Accounting
     Practice and Financial Reporting Standards currently in force and generally
     accepted accounting principles in the United States ("US GAAP"),
     consistently applied, and (i) present fairly the financial condition of the
     Company and its subsidiaries, as at the end of each of the relevant
     financial periods, and the results and cashflows of Shire and its
     subsidiaries, for each such period subject, in the case of the unaudited
     combined balance sheet, profit and loss account and consolidated cash flow,
     to customary year-end adjustments, (ii) in accordance with such Statements
     of Standard Accounting Practice, Financial Reporting Standards and such
     accounting principles, make proper provision for all liabilities, whether
     actual, deferred or contingent, and (iii) have been prepared after due and
     careful inquiry by Shire and, where applicable, its subsidiaries.

          (ee) Shire and each of its subsidiaries owns or possesses adequate
     rights to use pursuant to license, sublicense, agreement or permission all
     material patents, patent applications, trademarks, service marks, trade
     names, domain names, design rights, copyrights, database rights, topography
     rights, trade secrets and other know-how rights, rights in confidential
     information, proprietary rights and processes (in each case whether
     registered or unregistered and including applications for registration)
     arising or subsisting anywhere in the world ("Intellectual Property")

                                       9
<PAGE>

     necessary for the operation of the business of Shire and its subsidiaries
     as a whole as described in the Offering Circular. In respect of
     Intellectual Property devised, developed or created by or on behalf of
     Shire, which is used or which Shire expects to use, in Shire's current or
     foreseeable future business, or which is necessary for the operation of the
     business of Shire and its subsidiaries as described in the Offering
     Circular, Shire has taken all steps necessary to secure rights to such
     Intellectual Property from its employees and third party creators of that
     Intellectual Property; to the best of Shire's knowledge, none of the
     material technology or other Intellectual Property employed by Shire or any
     of its subsidiaries has been obtained or is being used by Shire or any of
     its subsidiaries in violation of any law or any contractual or fiduciary
     obligation binding upon Shire, any of its subsidiaries or any of their
     respective directors or executive officers or any of their respective
     employees. Except as described in the Offering Circular, to Shire's
     knowledge, neither Shire nor any of its subsidiaries has interfered with,
     infringed upon, misappropriated or violated any Intellectual Property of
     any third party and the continued operation of the business of Shire and
     its subsidiaries as described in the Offering Circular will not result in
     the same where any such event or circumstance would reasonably be expected
     to have a Material Adverse Effect; and except as described in the Offering
     Circular, Shire and its subsidiaries have not received and, to the best of
     Shire's knowledge, are not aware of any charge, complaint, claim, demand or
     notice alleging any such interference, infringement, misappropriation or
     violation (including any claim that Shire or any of its subsidiaries must
     take a license of or refrain from using any Intellectual Property of any
     third party) that would have a Material Adverse Effect, and, except as
     described in the Offering Circular, there are no actions, suits or judicial
     proceedings relating to Intellectual Property to which Shire or any of its
     subsidiaries is subject, and no such actions, suits or judicial proceedings
     are, to the best of Shire's knowledge, threatened by governmental
     authorities or other third parties; to the best of Shire's knowledge,
     except as described in the Offering Circular, there is no patent or
     published patent application which contains claims that dominate or may
     dominate any Intellectual Property described in the Offering Circular as
     being owned by or licensed to Shire or that interferes with the issued or
     pending claims of any such Intellectual Property; and, to the best of
     Shire's knowledge, except as described in the Offering Circular, there is
     and has been no infringement, interference, misappropriation or violation
     by any third parties of any Intellectual Property owned by Shire or any of
     its subsidiaries; and Shire and its subsidiaries have taken and will
     maintain reasonable measures to prevent the unauthorized use dissemination
     or publication of its trade secrets, proprietary information and other
     confidential information; and

          (ff) Shire and its subsidiaries (i) are in compliance with any and all
     applicable laws and all rules, regulations and orders relating to the
     protection of human health and safety (including occupational health and
     safety), the manufacture, processing, distribution, use, handling,
     transportation, disposal, treatment, storage or release of chemicals,
     pollutants, contaminants, wastes or hazardous or toxic substances or the
     protection or restoration of the environment or wildlife (collectively,
     "Environmental Laws"), (ii) have received all permits, licenses or other
     approvals required of them under applicable Environmental Laws to conduct
     their respective businesses and are in

                                       10
<PAGE>

     compliance with all terms and conditions of any such permit, license or
     approval, except where such noncompliance with Environmental Laws, failure
     to receive required permits, licenses or other approvals or failure to
     comply with the terms and conditions of such permits, licenses or approvals
     would not, singly or in the aggregate, have a Material Adverse Effect; and
     to Shire's knowledge, no material expenditures are or will be required to
     comply with the Environmental Laws.

     2. Subject to the terms and conditions herein set forth, (a) the Company
agrees to issue to the subscribers procured by the Purchasers or, failing which,
to each of the Purchasers, and each of the Purchasers agrees, severally and not
jointly, to procure subscribers for or, failing which, to subscribe, at a
subscription price per Security of $1,000, the aggregate principal amount of
Firm Securities set forth opposite the name of such Purchaser in Schedule I
hereto and (b) in the event and to the extent that the Purchasers shall exercise
the election to require the Company to issue Optional Securities as provided
below, the Company agrees to issue to each of the subscribers procured by the
Purchasers or, failing which, to each of the Purchasers, and each of the
Purchasers agrees, severally and not jointly, to procure subscribers for or,
failing which, to subscribe, at the subscription price per Security set forth in
clause (a) of this Section 2, that portion of the number of Optional Securities
as to which such election shall have been exercised (to be adjusted by the
Representatives so as to eliminate fractional shares) determined by multiplying
such number of Optional Securities by a fraction, the numerator of which is the
number of Optional Securities set forth opposite the name of such Purchaser in
Schedule I hereto and the denominator of which is the maximum number of Optional
Securities hereunder.

     The Company hereby grants to the Purchasers the right to procure
subscribers for or, failing which, to subscribe, at their election, up to
$50,000,000 aggregate principal amount of Optional Securities, at the
subscription price per Security set forth in clause (a) of the paragraph above.
Any such election may be exercised only by written notice from the
Representatives to the Company, given within a period of 30 calendar days after
the date hereof and setting forth the aggregate principal amount of Optional
Securities to be subscribed and the date on which such Optional Securities are
to be delivered, as determined by the Representatives, but in no event earlier
than the First Time of Delivery or, unless the Representatives and the Company
otherwise agree in writing, earlier than two or later than ten business days
after the date of such notice.

     As compensation to the Purchasers for their commitments hereunder, the
Company at each Time of Delivery (as defined in Section 4 hereof) will pay to
the Representatives, for the accounts of the several Purchasers, an underwriting
commission equal to $22.50 per Security to be delivered by the Company hereunder
at such Time of Delivery.

     The Purchasers may accept payment of the underwriting commission by
offsetting the amount thereof against the payment of the subscription price for
the Firm Securities or Optional Securities.

     3. Upon the authorization by the Representatives of the release of the Firm
Securities, the several Purchasers propose to procure subscribers for the Firm
Securities upon the terms and conditions set forth herein and in the Offering
Circular and each Purchaser hereby represents and warrants to, and agrees with
the Company and Shire that:

                                       11
<PAGE>

          (a) It will offer and sell the Securities only (i) to persons who it
     reasonably believes are "qualified institutional buyers" ("QIBs") within
     the meaning of Rule 144A under the Act in transactions meeting the
     requirements of Rule 144A or (ii) upon the terms and conditions set forth
     in Annex I to this Agreement;

          (b) It is an "accredited investor" within the meaning of Rule 501
     under the Act; and

          (c) It will not offer or sell the Securities by any form of general
     solicitation or general advertising, including but not limited to the
     methods described in Rule 502(c) under the Act.

     4. The Securities that the Purchasers procure subscribers for or, failing
which, subscribe hereunder shall be delivered by or on behalf of the Company to
Goldman Sachs International, for the respective accounts of such subscribers or
Purchasers, as the case may be, against payment by or on behalf of such
subscribers or Purchasers, respectively, of the subscription price therefor by
wire transfer of federal (same-day) funds to the account specified by the
Company to the Representatives at least forty-eight hours in advance. The time
and date of such delivery and payment shall be, with respect to the Firm
Securities, 2:00 p.m., London time, on August 21, 2001, or such other time and
date as Goldman Sachs International and the Company may agree upon and, with
respect to the Optional Securities, 2:00 p.m., London time, on the dates
specified by Goldman Sachs International in the written notices given by Goldman
Sachs International of the Purchasers' elections to procure subscribers for or,
failing which, to subscribe such Optional Securities, or such other time and
date as Goldman Sachs International and the Company may agree upon; provided,
that there shall be no more than two such times and dates with respect to the
Optional Securities. Such time and date for delivery of the Firm Securities is
herein called the "First Time of Delivery", and each such time and date for
delivery is herein called a "Time of Delivery". It is understood that the
Securities will initially be represented by global securities in book-entry form
(the "Global Securities"), one of which will be deposited by or on behalf of the
Company with The Depositary Trust Company ("DTC") or its nominee and the other
of which will be deposited by or on behalf of the Company with The Bank of New
York, as common depositary for Euroclear Bank S.A./N.V. and Clearstream Banking,
S.A. (the "Common Depositary"). The Global Securities will be made available for
checking at least twenty-four hours prior to the Time of Delivery through the
facilities of the Book-Entry Depositary and the Common Depositary.

     The documents to be delivered at the Time of Delivery by or on behalf of
the parties hereto pursuant to Section 7 hereof, including the cross-receipt for
the Securities and any additional documents requested by the Purchasers pursuant
to Section 7(j) hereof, will be delivered at the offices of Cleary, Gottlieb,
Steen and Hamilton, City Place House, 55 Basinghall Street, London EC2V 5EH,
telephone: +44 (0)20 7614 2220, facsimile: +44 (0)20 7600 1698 (the "Closing
Location"), and the Securities will be delivered through the facilities of DTC
and the Common Depositary, all at the Time of Delivery. A meeting will be held
at the Closing Location at 3:00 p.m., London time, on the Business Day next
preceding the Time of Delivery, at which meeting the final drafts of the
documents to be delivered pursuant to the preceding sentence will be available
for review by the parties hereto. For the purposes of this Section 4, "Business
Day" shall mean each Monday, Tuesday, Wednesday, Thursday and Friday which is

                                       12
<PAGE>

not a day on which banking institutions in London or New York City are generally
authorized or obligated by law or executive order to close.

     5. The Company and Shire agree with each of the Purchasers as follows:

          (a) To prepare the Offering Circular in a form approved by the
     Representatives; and to make no further amendment or any supplement to the
     Offering Circular prior to the last Time of Delivery which shall be
     reasonably disapproved by you promptly after reasonable notice thereof; and
     to file promptly all reports required to be filed by Shire with the
     Commission pursuant to Section 13(a), 13(c) or 15(d) of the Exchange Act
     subsequent to the date of the Offering Circular and for so long as the
     delivery of an offering circular is required in connection with the
     offering or sale of the Securities;

          (b) Promptly from time to time to take such action as you may
     reasonably request to qualify the Securities, the Preference Shares
     issuable upon conversion of the Securities or the ordinary shares and ADSs
     issuable in exchange for the Preference Shares for offering and sale under
     the securities laws of such jurisdictions as you may reasonably request and
     to comply with such laws so as to permit the continuance of sales and
     dealings therein in such jurisdictions for as long as may be reasonably
     necessary to complete the distribution of the Securities by the Purchasers,
     provided that in connection therewith the Company shall not be required to
     qualify as a foreign corporation or to file a general consent to service of
     process in any jurisdiction or be subjected to taxation in more than a
     nominal amount;

          (c) Prior to 10:00 a.m., London time, on the third London Business Day
     after the date hereof, or as soon thereafter as is practicable, and from
     time to time, to furnish the Purchasers with copies of the Offering
     Circular, and any amendment or supplement containing amendments to the
     financial statements covered by such report(s), signed by the accountants,
     and additional written and electronic copies thereof in London in such
     quantities as the Representatives may reasonably request, and, if the
     delivery of an Offering Circular is required at any time prior to the
     expiration of six months after the time of issue of the Offering Circular
     in connection with the offering or sale of the Securities and if at such
     time any event shall have occurred as a result of which the Offering
     Circular as then amended or supplemented would include an untrue statement
     of a material fact or omit to state any material fact necessary in order to
     make the statements therein, in the light of the circumstances under which
     they were made when such Offering Circular is delivered, not misleading,
     or, if for any other reason it shall be necessary or desirable during such
     same period to amend or supplement the Offering Circular or to file under
     the Exchange Act any document incorporated by reference in the Offering
     Circular in order to comply with the Exchange Act, to notify you and upon
     your request to file such document and to prepare and furnish without
     charge to each Purchaser and to any dealer in Securities as many written
     and electronic copies as you may from time to time reasonably request of an
     amended Offering Circular or a supplement to the Offering Circular which
     will correct such statement or omission or effect such compliance;

                                       13
<PAGE>

          (d) During the period beginning from the date hereof and continuing to
     the date 90 days after the date hereof, (i) not to, directly or indirectly,
     offer, sell, contract to sell or otherwise dispose of, except as provided
     hereunder any securities of the Company or Shire that are substantially
     similar to the Securities, the Preference Shares, the ordinary shares or
     the ADSs, including but not limited to any securities that are convertible
     into or exchangeable for, or that represent the right to receive, ordinary
     shares or any such substantially similar securities (other than pursuant to
     employee stock option plans existing on, or upon the conversion or exchange
     of convertible or exchangeable securities outstanding as of, the date of
     this Agreement, including the Exchangeable Shares of Shire Acquisition
     Inc., Shire's unsecured convertible zero coupon loan note due to Arenol
     Corporation and any remaining shares of Roberts Pharmaceutical
     Corporation); and (ii) not to permit any of the officers and directors of
     Shire to engage in any of the aforementioned transactions on their own
     behalf, in each case without your prior written consent; provided, however,
     that (i) after September 8, 2001, Dr. Francesco Bellini may exercise
     options representing the right to receive up to 3,413,550 ordinary shares
     or ADSs representing 3,413,550 ordinary shares and sell or otherwise
     dispose of such ordinary shares or ADSs; and (ii) James Grant may exercise
     options representing the right to receive up to 179,321 ordinary shares or
     ADSs representing up to 179,321 ordinary shares and sell or dispose of such
     ordinary shares or ADSs;

          (e) Not to be or become, at any time prior to the expiration of three
     years after the last Time of Delivery, an open-end investment company, unit
     investment trust, closed-end investment company or face-amount certificate
     company that is or is required to be registered under Section 8 of the
     Investment Company Act;

          (f) If at any time Shire is exempt from registration under Section
     12(b) of the Exchange Act and is not subject to Section 13 or 15(d) of the
     Exchange Act, for the benefit of holders from time to time of Securities,
     to furnish at its expense, upon request, to holders of Securities and
     prospective purchasers of Securities information satisfying the
     requirements of subsection (d)(4)(i) of Rule 144A under the Act;

          (g) To use their best efforts to cause the Securities to be eligible
     for the PORTAL trading system of the National Association of Securities
     Dealers, Inc.;

          (h) During a period of five years from the date of the Offering
     Circular, to furnish to you copies of all reports or other communications
     (financial or other) furnished to shareholders of Shire, and to deliver to
     you (i) as soon as they are available, copies of any reports and financial
     statements furnished to or filed with the Commission or any securities
     exchange on which any class of securities of Shire is listed; and (ii) such
     additional information otherwise generally made publicly available
     concerning the business and financial condition of Shire as you may from
     time to time reasonably request (such financial statements to be on a
     consolidated basis to the extent the accounts of Shire and its subsidiaries
     are consolidated in reports furnished to its shareholders generally or to
     the Commission);

                                       14
<PAGE>

          (i) During the period of two years after the Time of Delivery, not to,
     and not to permit any of its "affiliates" (as defined in Rule 144 under the
     Act) to, resell any of the Securities that constitute "restricted
     securities" under Rule 144 that have been reacquired by any of them;

          (j) Not to (and to cause its subsidiaries not to) take, directly or
     indirectly, any action which is designed to or which constitutes or which
     might reasonably be expected to cause or result in stabilization or
     manipulation of the price of any security of the Company or Shire to
     facilitate the issue or sale of the Securities, the Preference Shares, the
     ordinary shares or the ADSs;

          (k) To use the net proceeds received from the issue of the Securities
     pursuant to this Agreement in the manner specified in the Offering Circular
     under the caption "Use of Proceeds";

          (l) In the case of Shire, to reserve and keep available at all times,
     free of preemptive rights, ordinary shares for the purpose of satisfying
     any obligation to issue ordinary shares in exchange for the Preference
     Shares;

          (m) To use their best efforts to have, subject to notice of issuance,
     the ordinary shares admitted to the official list of the UKLA and admitted
     to trading on the London Stock Exchange, and to comply with all filing and
     other requirements under the Companies Act, the FSA, the Listing Rules and
     all other relevant statutes and regulations;

          (n) To use their best efforts to have, prior to September 30, 2001,
     the Securities (i) admitted to the official list of the UKLA and admitted
     to trading on the London Stock Exchange or (ii) listed on the Luxembourg
     Stock Exchange; and

          (o) To pay or cause to be paid any stamp duty or stamp duty reserve
     tax imposed by the United Kingdom upon the issue of the ordinary shares to
     the Depositary.

     6. The Company and Shire covenant and agree with the several Purchasers
that the Company will pay or cause to be paid the following: (i) the fees,
disbursements and expenses of the Company's counsel and Shire's counsel and
accountants in connection with the issue of the Securities, the Preference
Shares issuable upon conversion of the Securities and the ordinary shares and
ADSs issuable in exchange for the Preference Shares and all other expenses in
connection with the preparation and printing of the Offering Circular and
amendments and supplements thereto and the mailing and delivering of copies
thereof to the Purchasers; (ii) all expenses in connection with the
qualification of the Securities, the ordinary shares and the ADSs for offering
and sale under state securities laws as provided in Section 5(b) hereof; (iii)
all fees and expenses in connection with listing the Securities on the official
list of the UKLA and admission of the Securities to trading on the London Stock
Exchange; (iv) the cost of preparing certificates for the Securities; (v) any
fees charged by securities rating services for rating the Securities; (vi) the
fees and expenses of the Trustee and any agent of the Trustee and the fees and
disbursements of counsel for the Trustee in connection with the Indenture and
the Securities; (vii) the fees and expenses (including fees and disbursements of
counsel), if any, of the Depositary and any custodian appointed under the
Deposit Agreement, other than the fees and

                                       15
<PAGE>

expenses to be paid by holders of ADRs; (viii) any costs incurred in connection
with the designation of the Securities for trading in PORTAL and the listing and
admission of the ordinary shares and ADSs issuable in exchange for the
Preference Shares; and (ix) the fees, disbursements and expenses of the
Company's counsel and Shire's counsel and accountants in connection with the
registration of the Securities, the ordinary shares and the ADSs under the Act.

     7. The obligations of the Purchasers hereunder shall be subject, in their
discretion, at each Time of Delivery, to the condition that all representations
and warranties and other statements of the Company and Shire herein are, at and
as of such Time of Delivery, true and correct, the condition that the Company
and Shire shall have performed in all material respects all of their obligations
hereunder theretofore to be performed, and the following additional conditions:

          (a) Cleary, Gottlieb, Steen & Hamilton, counsel for the Purchasers,
     shall have furnished to you such opinion or opinions, dated such Time of
     Delivery, in form and substance reasonably satisfactory to you;

          (b) Cahill, Gordon & Reindel, U.S. counsel for Shire, shall have
     furnished to you their written opinion, dated such Time of Delivery, in
     substantially the form attached hereto as Exhibit A;

          (c) Slaughter and May, English counsel for Shire, shall have furnished
     to you their written opinion, dated such Time of Delivery, in substantially
     the form attached hereto as Exhibit B;

          (d) Tatjana May, General Counsel of Shire, shall have furnished to you
     her written opinion, dated such Time of Delivery, in substantially the form
     attached hereto as Exhibit C;

          (e) Maples and Calder Europe, Cayman Islands counsel for the Company,
     shall have furnished to you their written opinion, dated such Time of
     Delivery, in substantially the form attached hereto as Exhibit D;

          (f) On the date of the Offering Circular prior to the execution of
     this Agreement and also at the Time of Delivery, Arthur Andersen shall have
     furnished to you a letter or letters, dated the respective dates of
     delivery thereof, in form and substance satisfactory to you, to the effect
     set forth in Exhibit E hereto;

          (g) (i) Neither Shire nor any of its subsidiaries shall have sustained
     since the date of the latest audited financial statements included or
     incorporated by reference in the Offering Circular any loss or interference
     with its business from fire, explosion, flood or other calamity, whether or
     not covered by insurance, or from any labor dispute or court or
     governmental action, order or decree, otherwise than as set forth or
     contemplated or incorporated by reference in the Offering Circular, and
     (ii) since the respective dates as of which information is given or
     incorporated by reference in the

                                       16
<PAGE>

     Offering Circular there shall not have been any change in the capital stock
     or long-term debt of Shire or any of its subsidiaries or any change, or any
     development involving a prospective change, in or affecting the general
     affairs, management, financial position, shareholders' equity or results of
     operations of Shire and its subsidiaries, otherwise than as set forth or
     contemplated in the Offering Circular, the effect of which, in any such
     case described in clause (i) or (ii), is in the judgment of the
     Representatives so material and adverse as to make it impracticable or
     inadvisable to proceed with the issuance, sale or delivery of the
     Securities being delivered at such Time of Delivery on the terms and in the
     manner contemplated in the Offering Circular;

          (h) There shall not have occurred any of the following: (i) a
     suspension or material limitation in trading in securities generally on the
     New York Stock Exchange, NASDAQ, the London Stock Exchange or the Toronto
     Stock Exchange; (ii) a suspension or material limitation in trading in the
     Company's securities on NASDAQ or the London Stock Exchange; (iii) a
     general moratorium on commercial banking activities in New York, the United
     Kingdom, Canada or the Cayman Islands declared by the relevant authorities;
     (iv) a change or development involving a prospective change in U.K.
     taxation adversely affecting Shire, the Company, the Securities or the
     transfer thereof or the imposition or proposal of exchange controls by the
     United States, the United Kingdom or the Cayman Islands; (v) the outbreak
     or escalation of hostilities involving the United States, the United
     Kingdom, Canada or the Cayman Islands or the declaration by the United
     States, the United Kingdom, Canada or the Cayman Islands of a national
     emergency or war, if the effect of any such event specified in this clause
     (v) in the judgment of the Representatives makes it impracticable or
     inadvisable to proceed with the issuance, sale or delivery of the
     Securities on the terms and in the manner contemplated in the Offering
     Circular; or (vi) the occurrence of any material adverse change in the
     existing financial, political or economic conditions in the United States,
     the United Kingdom, Canada, the Cayman Islands or elsewhere which, in the
     judgment of the Representatives would materially and adversely affect the
     financial markets or the market for the Securities and other debt
     securities;

          (i) The Company, Shire and The Bank of New York shall have executed
     and delivered the Indenture and the Company and Shire shall have executed
     and delivered the Registration Rights Agreement;

          (j) The Securities shall have been designated for trading on PORTAL;

          (k) Shire shall have furnished or caused to be furnished to you
     lock-up letters from each of its officers and directors in form and
     substance satisfactory to you consistent with Section 5(d);

          (l) Shire shall have caused an election for the Company to be filed
     with the U.S. Internal Revenue Service to disregard the Company as an
     entity separate from its owner for U.S. federal income tax purposes, where
     the effective date of

                                       17
<PAGE>

     that election shall be on or prior to the day preceding the date of
     issuance of the Securities; and

          (m) Each of the Company and Shire shall have furnished or caused to be
     furnished to you at such Time of Delivery certificates of its officers,
     satisfactory to you as to the accuracy of the representations and
     warranties of the Company and Shire herein at and as of such Time of
     Delivery, as to the performance by the Company and Shire, in all material
     respects, of all of its obligations hereunder to be performed at or prior
     to such Time of Delivery, as to the matters set forth in subsections (g)(i)
     and (ii) of this Section and as to such other matters as you may reasonably
     request.

     8. (a) The Company and Shire, jointly and severally, will indemnify and
hold harmless each Purchaser against any losses, claims, damages or liabilities,
joint or several, to which such Purchaser may become subject, under the Act or
otherwise, insofar as such losses, claims, damages or liabilities (or actions in
respect thereof) arise out of or are based upon an untrue statement or alleged
untrue statement of a material fact contained in the Offering Circular or any
amendment or supplement thereto, or arise out of or are based upon the omission
or alleged omission to state therein a material fact necessary to make the
statements therein not misleading, and will reimburse each Purchaser for any
legal or other expenses reasonably incurred by such Purchaser in connection with
investigating or defending any such action or claim as such expenses are
incurred; provided, however, that the Company and Shire shall not be liable in
any such case to the extent that any such loss, claim, damage or liability
arises out of or is based upon an untrue statement or alleged untrue statement
or omission or alleged omission made in the Offering Circular or any such
amendment or supplement in reliance upon and in conformity with written
information furnished to the Company or Shire by any Purchaser through the
Representatives expressly for use therein.

     (b) Each Purchaser, severally and not jointly, will indemnify and hold
harmless the Company and Shire against any losses, claims, damages or
liabilities to which the Company or Shire may become subject, under the Act or
otherwise, insofar as such losses, claims, damages or liabilities (or actions in
respect thereof) arise out of or are based upon an untrue statement or alleged
untrue statement of a material fact contained in the Offering Circular or any
amendment or supplement thereto, or arise out of or are based upon the omission
or alleged omission to state therein a material fact necessary to make the
statements therein not misleading, in each case to the extent, but only to the
extent, that such untrue statement or alleged untrue statement or omission or
alleged omission was made in the Offering Circular or any such amendment or
supplement in reliance upon and in conformity with written information furnished
to the Company or Shire by such Purchaser through the Representatives expressly
for use therein; and will reimburse the Company and Shire for any legal or other
expenses reasonably incurred by the Company or Shire in connection with
investigating or defending any such action or claim as such expenses are
incurred.

     (c) Promptly after receipt by an indemnified party under subsection (a) or
(b) above of notice of the commencement of any action, such indemnified party
shall, if a claim in respect thereof is to be made against the indemnifying
party under such subsection, notify the indemnifying party in writing of the
commencement thereof; but the omission so to notify the

                                       18
<PAGE>

indemnifying party shall not relieve it from any liability which it may have to
any indemnified party otherwise than under such subsection. In case any such
action shall be brought against any indemnified party and it shall notify the
indemnifying party of the commencement thereof, the indemnifying party shall be
entitled to participate therein and, to the extent that it shall wish, jointly
with any other indemnifying party similarly notified, to assume the defense
thereof, with counsel satisfactory to such indemnified party (who shall not,
except with the consent of the indemnified party, be counsel to the indemnifying
party), and, after notice from the indemnifying party to such indemnified party
of its election so to assume the defense thereof, the indemnifying party shall
not be liable to such indemnified party under such subsection for any legal
expenses of other counsel or any other expenses, in each case subsequently
incurred by such indemnified party, in connection with the defense thereof other
than reasonable costs of investigation unless such indemnified party shall have
reasonably concluded that there may be defenses available to it that are
different from or additional to those available to one or all of the
indemnifying parties, in which case the indemnifying party's liability for the
fees and expenses of the indemnified party's counsel shall continue. No
indemnifying party shall, without the written consent of the indemnified party,
effect the settlement or compromise of, or consent to the entry of any judgment
with respect to, any pending or threatened action or claim in respect of which
indemnification or contribution may be sought hereunder (whether or not the
indemnified party is an actual or potential party to such action or claim)
unless such settlement, compromise or judgment (i) includes an unconditional
release of the indemnified party from all liability arising out of such action
or claim and (ii) does not include a statement as to or an admission of fault,
culpability or a failure to act, by or on behalf of any indemnified party.

     (d) If the indemnification provided for in this Section 8 is unavailable to
or insufficient to hold harmless an indemnified party under subsection (a) or
(b) above in respect of any losses, claims, damages or liabilities (or actions
in respect thereof) referred to therein, then each indemnifying party shall
contribute to the amount paid or payable by such indemnified party as a result
of such losses, claims, damages or liabilities (or actions in respect thereof)
in such proportion as is appropriate to reflect the relative benefits received
by the Company and/or Shire on the one hand and the Purchasers on the other from
the issue and subscription of the Securities. If, however, the allocation
provided by the immediately preceding sentence is not permitted by applicable
law or if the indemnified party failed to give the notice required under
subsection (c) above, then each indemnifying party shall contribute to such
amount paid or payable by such indemnified party in such proportion as is
appropriate to reflect not only such relative benefits but also the relative
fault of the Company and/or Shire on the one hand and the Purchasers on the
other in connection with the statements or omissions which resulted in such
losses, claims, damages or liabilities (or actions in respect thereof), as well
as any other relevant equitable considerations. The relative benefits received
by the Company and/or Shire on the one hand and the Purchasers on the other
shall be deemed to be in the same proportion as the total net proceeds from the
offering of the Securities subscribed under this Agreement (before deducting
expenses) received by the Company and/or Shire bear to the total underwriting
commissions received by the Purchasers with respect to the Securities subscribed
under this Agreement, in each case as set forth in the Offering Circular. The
relative fault shall be determined by reference to, among other things, whether
the untrue or alleged untrue statement of a material fact or the omission or
alleged omission to state a material fact relates to information supplied by the
Company or Shire

                                       19
<PAGE>

on the one hand or the Purchasers on the other and the parties' relative intent,
knowledge, access to information and opportunity to correct or prevent such
statement or omission. The Company, Shire and the Purchasers agree that it would
not be just and equitable if contributions pursuant to this subsection (d) were
determined by pro rata allocation (even if the Purchasers were treated as one
entity for such purpose) or by any other method of allocation which does not
take account of the equitable considerations referred to above in this
subsection (d). The amount paid or payable by an indemnified party as a result
of the losses, claims, damages or liabilities (or actions in respect thereof)
referred to above in this subsection (d) shall be deemed to include any legal or
other expenses reasonably incurred by such indemnified party in connection with
investigating or defending any such action or claim. Notwithstanding the
provisions of this subsection (d), no Purchaser shall be required to contribute
any amount in excess of the amount by which the total price at which the
Securities underwritten by it and distributed to investors were offered to
investors exceeds the amount of any damages which such Purchaser has otherwise
been required to pay by reason of such untrue or alleged untrue statement or
omission or alleged omission. The Purchasers' obligations in this subsection (d)
to contribute are several in proportion to their respective underwriting
obligations and not joint. The Company's and Shire's obligations under this
subsection (d) are joint and several.

     (e) All sums payable to an indemnified party under this Section 8 shall be
paid free and clear of all deductions or withholdings unless the deduction or
withholding is required by law. If the deduction or withholding is required by
U.K. law, the indemnified party shall be paid such additional amount as shall be
required to ensure that the net amount received by the payee will equal the full
amount which would have been received by it had no deduction or withholding been
made; provided, however, that, to the extent that any indemnified party or any
associated person actually receives a credit, relief, remission or repayment of
any nature in respect of or relating to the deduction or withholding, the
indemnified party shall pay an amount equal to the credit, relief, remission or
repayment to the party who made the increased payment pursuant to this clause.

     (f) The obligations of the Company and Shire under this Section 8 shall be
in addition to any liability which they may otherwise have and shall extend,
upon the same terms and conditions, to each person, if any, who controls any
Purchaser within the meaning of the Act; and the obligations of the Purchasers
under this Section 8 shall be in addition to any liability which the respective
Purchasers may otherwise have and shall extend, upon the same terms and
conditions, to each officer and director of Shire and the Company and to each
person, if any, who controls Shire and the Company within the meaning of the
Act.

     9. (a) If any Purchaser shall default in its obligation to procure
subscribers for or, failing which, to subscribe the Securities which it has
agreed to do so hereunder at a Time of Delivery, you may in your discretion
arrange for you or another party or other parties to subscribe such Securities
on the terms contained herein. If within thirty-six hours after such default by
any Purchaser you do not arrange for the subscription of such Securities, then
the Company shall be entitled to a further period of thirty-six hours within
which to procure another party or other parties satisfactory to you to subscribe
such Securities on such terms. In the event that, within the respective
prescribed periods, you notify the Company that you have so arranged for the
subscription of such Securities, or the Company notifies you that it has so
arranged for the

                                       20
<PAGE>

subscription of such Securities, you or the Company shall have the right to
postpone such Time of Delivery for a period of not more than seven days, in
order to effect whatever changes may thereby be made necessary in the Offering
Circular, or in any other documents or arrangements, and the Company agrees to
prepare promptly any amendments to the Offering Circular which in your opinion
may thereby be made necessary. The term "Purchaser" as used in this Agreement
shall include any person substituted under this Section with like effect as if
such person had originally been a party to this Agreement with respect to such
Securities.

     (b) If, after giving effect to any arrangements for the subscription of the
Securities of a defaulting Purchaser or Purchasers by you and the Company as
provided in subsection (a) above, the aggregate principal amount of such
Securities which have not been subscribed does not exceed one-tenth of the
aggregate principal amount of all the Securities to be issued at such Time of
Delivery, then the Company shall have the right to require each non-defaulting
Purchaser to procure subscribers for or, failing which, to subscribe the
principal amount of Securities which such Purchaser agreed to do so hereunder at
such Time of Delivery and, in addition, to require each non-defaulting Purchaser
to procure subscribers for or, failing which, to subscribe its pro rata share
(based on the principal amount of Securities which such Purchaser agreed to
procure subscribers for or, failing which, to subscribe hereunder) of the
Securities of such defaulting Purchaser or Purchasers for which such
arrangements have not been made; but nothing herein shall relieve a defaulting
Purchaser from liability for its default.

     (c) If, after giving effect to any arrangements for the subscription of the
Securities of a defaulting Purchaser or Purchasers by you and the Company as
provided in subsection (a) above, the aggregate principal amount of such
Securities which remains unsubscribed exceeds one-tenth of the aggregate
principal amount of all the Securities to be issued at such Time of Delivery, or
if the Company shall not exercise the right described in subsection (b) above to
require non-defaulting Purchasers to procure subscribers for or, failing which,
to subscribe, Securities of a defaulting Purchaser or Purchasers, then this
Agreement (or, with respect to an Optional Time of Delivery, the obligation of
the Purchasers to procure subscribers for or, failing which, to subscribe and of
the Company to issue the Optional Securities) shall thereupon terminate, without
liability on the part of any non-defaulting Purchaser or the Company, except for
the expenses to be borne by the Company and the Purchasers as provided in
Section 6 hereof and the indemnity and contribution agreements in Section 8
hereof; but nothing herein shall relieve a defaulting Purchaser from liability
for its default.

     10. The respective indemnities, agreements, representations, warranties and
other statements of the Company, Shire and the several Purchasers, as set forth
in this Agreement or made by or on behalf of them, respectively, pursuant to
this Agreement, shall remain in full force and effect, regardless of any
investigation (or any statement as to the results thereof) made by or on behalf
of any Purchaser or any controlling person of any Purchaser, the Company, Shire
or any officer or director or controlling person of the Company or Shire and
shall survive delivery of and payment for the Securities.

     11. If this Agreement shall be terminated pursuant to Section 9 hereof, the
Company and Shire shall not then be under any liability to any Purchaser except
as provided in Section 6 and Section 8 hereof, but, if for any other reason any
Securities are not delivered by or on behalf of the Company as provided herein,
the Company will reimburse the Purchasers through Bear,

                                       21
<PAGE>

Stearns International Limited for all out-of-pocket expenses approved in writing
by the Representatives, including fees and disbursements of counsel, reasonably
incurred by the Purchasers in making preparations for the subscription, sale and
delivery of the Securities not so delivered, but the Company shall then be under
no further liability to any Purchaser in respect of the Securities not so
delivered except as provided in Sections 6 and 8 hereof.

     12. In all dealings hereunder, you shall act on behalf of each of the
Purchasers, and the parties hereto shall be entitled to act and rely upon any
statement, request, notice or agreement on behalf of any Purchaser made or given
by you jointly or by Bear, Stearns International Limited on your behalf.

     All statements, requests, notices and agreements hereunder shall be in
writing, and if to the Purchasers shall be delivered or sent by mail, telex or
facsimile transmission to the Purchasers in care of Bear, Stearns International
Limited, One Canada Square, London E14 5AD, Attention: Equity Capital Markets,
facsimile no. +44 20 7516 5187, with a copy to; Goldman Sachs International,
Peterborough Court, 133 Fleet Street, London EC4A 2BB, England, Attention:
Equity Capital Markets, facsimile transmission no. +44 20 7774 5670; and if to
the Company shall be delivered or sent by registered mail, telex or facsimile
transmission to the address of the Company set forth in the Offering Circular,
Attention: Company Secretary. Any such statements, requests, notices or
agreements shall take effect upon receipt thereof.

     13. This Agreement shall be binding upon, and inure solely to the benefit
of, the Purchasers, the Company, Shire and, to the extent provided in Sections 8
and 10 hereof, the officers and directors of the Company and Shire and each
person who controls the Company, Shire or any Purchaser, and their respective
heirs, executors, administrators, successors and assigns, and no other person
shall acquire or have any right under or by virtue of this Agreement. No
purchaser of any of the Securities from any Purchaser shall be deemed a
successor or assign by reason merely of such purchase.

     14. Time shall be of the essence of this Agreement.

     15. Each of the parties hereto irrevocably (a) agrees that any legal suit,
action or proceeding against the Company or Shire brought by any Purchaser or by
any person who controls any Purchaser arising out of or based upon this
Agreement or the transactions contemplated hereby or any other document
delivered hereunder may be instituted in any U.S. federal or New York court
located in the Borough of Manhattan, The City of New York, New York, (b) waives,
to the fullest extent it may effectively do so, any objection which it may now
or hereafter have to the laying of venue of any such proceeding and (c) submits
to the non-exclusive jurisdiction of such courts in any such suit, action or
proceeding. Nothing herein shall preclude any legal suit, action or proceeding
against the Company or Shire being instituted in a court in London, England. The
Company has appointed CT Corporation System, New York, New York, as its
authorized agent (the "Authorized Agent") upon whom process may be served in any
such action arising out of or based on this Agreement or the transactions
contemplated hereby which may be instituted in any New York court by any
Purchaser or by any person who controls any Purchaser, expressly consents to the
jurisdiction of any such court in respect of any such action, and waives any
other requirements of or objections to personal jurisdiction with respect
thereto. Such appointment shall be irrevocable. The Company represents and
warrants

                                       22
<PAGE>

that the Authorized Agent has agreed to act as such agent for service of process
and agrees to take any and all action, including the filing of any and all
documents and instruments, that may be necessary to continue such appointment in
full force and effect as aforesaid. Service of process upon the Authorized Agent
and written notice of such service to the Company shall be deemed, in every
respect, effective service of process upon the Company.

     16. In respect of any judgment or order given or made for any amount due
hereunder that is expressed and paid in a currency (the "judgment currency")
other than United States dollars, the Company and Shire will indemnify each
Purchaser against any loss incurred by such Purchaser as a result of any
variation as between (a) the rate of exchange at which the United States dollar
amount is converted into the judgment currency for the purpose of such judgment
or order and (b) the rate of exchange at which an Purchaser is able to purchase
United States dollars with the amount of the judgment currency actually received
by such Purchaser. The foregoing indemnity shall constitute a separate and
independent obligation of the Company and Shire and shall continue in full force
and effect notwithstanding any such judgment or order as aforesaid. The term
"rate of exchange" shall include any premiums and costs of exchange payable in
connection with the purchase of or conversion into United States dollars. The
Company's and Shire's obligations under this Section 16 are joint and several.

     17. This Agreement shall be governed by and construed in accordance with
the laws of the State of New York, United States of America.

     18. This Agreement may be executed by any one or more of the parties hereto
in any number of counterparts, each of which shall be deemed to be an original,
but all such counterparts shall together constitute one and the same instrument.

                                       23
<PAGE>

     If the foregoing is in accordance with your understanding, please sign and
return to us five counterparts hereof, and upon the acceptance hereof by you, on
behalf of each of the Purchasers, this letter and such acceptance hereof shall
constitute a binding agreement among each of the Purchasers, Shire and the
Company.

                             Shire Finance Limited

                             By: ..............................................
                                 Name:
                                 Title:

                             Shire Pharmaceuticals Group plc

                             By: ..............................................
                                 Name:
                                 Title:

Accepted as of the date hereof:

Bear, Stearns International Limited

By:............................................
               (Attorney-in-fact)

Goldman Sachs International

By:............................................
               (Attorney-in-fact)

         On behalf of each of the Purchasers

                                       24
<PAGE>

<TABLE>
<CAPTION>
                                   SCHEDULE I
                                                                      Aggregate
                                                                   Principal Amount          Aggregate Principal
                                                                       of Firm                Amount of Optional
                                                                      Securities               Securities to be
                                                                   to be Subscribed             Subscribed if
                                                                                                Maximum Option
                                                                                                  Exercised
                          Purchaser

<S>                                                                  <C>                      <C>
Bear, Stearns International Limited..............................    $157,500,000             $180,000,000
Goldman Sachs International......................................     157,500,000              180,000,000
Merrill Lynch International Limited..............................      26,250,000               30,000,000
WestLB Panmure Limited...........................................       8,750,000               10,000,000

                                                               -------------------       --------------------------
                  Total..........................................  $350,000,000                 $400,000,000
                                                               ===================       ==========================
</TABLE>

                                      I-1
<PAGE>

                                                                         ANNEX I

                              SELLING RESTRICTIONS

     (1) The Securities have not been and will not be registered under the Act
and may not be offered or sold within the United States or to, or for the
account or benefit of, U.S. persons except in accordance with Regulation S under
the Act or pursuant to an exemption from the registration requirements of the
Act. Each Purchaser represents that it has offered and sold the Securities, and
will offer and sell the Securities (i) as part of their distribution at any time
and (ii) otherwise until 40 days after the later of the commencement of the
offering and the Time of Delivery, only in accordance with Rule 903 of
Regulation S or Rule 144A under the Act. Accordingly, each Purchaser agrees that
neither it, its affiliates nor any persons acting on its or their behalf has
engaged or will engage in any directed selling efforts with respect to the
Securities, and it and they have complied and will comply with the offering
restrictions requirement of Regulation S. Each Purchaser agrees that, at or
prior to confirmation of sale of Securities (other than a sale pursuant to Rule
144A), it will have sent to each distributor, dealer or person receiving a
selling concession, fee or other remuneration that purchases Securities from it
during the restricted period a confirmation or notice to substantially the
following effect:

          "The Securities covered hereby have not been registered under the U.S.
     Securities Act of 1933 (the "Securities Act") and may not be offered and
     sold within the United States or to, or for the account or benefit of, U.S.
     persons (i) as part of their distribution at any time or (ii) otherwise
     until 40 days after the later of the commencement of the offering and the
     closing date, except in either case in accordance with Regulation S (or
     Rule 144A if available) under the Securities Act. Terms used above have the
     meaning given to them by Regulation S."

Terms used in this paragraph have the meanings given to them by Regulation S.

     Each Purchaser further agrees that it has not entered and will not enter
into any contractual arrangement with respect to the distribution or delivery of
the Securities, except with its affiliates or with the prior written consent of
the Company.

     (2) Notwithstanding the foregoing, Securities in registered form may be
offered, sold and delivered by the Purchasers in the United States and to U.S.
persons pursuant to Section 3 of this Agreement without delivery of the written
statement required by paragraph (1) above.

     (3) Each Purchaser further represents and agrees that (a) it has not
offered or sold and will not offer or sell any Securities to persons in the
United Kingdom except to persons whose ordinary activities involve them in
acquiring, holding, managing or disposing of investments (as principal or agent)
for the purposes of their businesses or otherwise in circumstances which have
not resulted and will not result in an offer to the public in the United Kingdom
within the meaning of the Public Offers of Securities Regulations 1995, (b) it
has complied, and will comply, with all applicable provisions of the Financial
Services Act of 1986 of Great Britain with respect to anything done by it in
relation to the Securities in, from or otherwise involving the United Kingdom,
and (c) it has only issued or passed on and will only issue or pass on in the

<PAGE>

United Kingdom any document received by it in connection with the issuance of
the Securities to a person who is of a kind described in Article 11(3) of the
Financial Services Act 1986 (Investment Advertisements) (Exemptions) Order 1996
of Great Britain or is a person to whom the document may otherwise lawfully be
issued or passed on.

     (4) Each Purchaser agrees that it will not offer, sell or deliver any of
the Securities in any jurisdiction outside the United States except under
circumstances that will result in compliance with the applicable laws thereof,
and that it will take at its own expense whatever action is required to permit
its purchase and resale of the Securities in such jurisdictions. Each Purchaser
understands that no action has been taken to permit a public offering in any
jurisdiction outside the United States where action would be required for such
purpose. Each Purchaser agrees not to cause any advertisement of the Securities
to be published in any newspaper or periodical or posted in any public place and
not to issue any circular relating to the Securities, except in any such case
with the Representatives' express written consent and then only at its own risk
and expense.

     (5) Each Purchaser agrees that it will not offer, sell, transfer or deliver
Securities in or from The Netherlands, as part of their initial distribution or
as part of any re-offering, and will not distribute or circulate the Offering
Circular or any other document in respect of the offering in The Netherlands,
other than to individuals or legal entities which include, but are not limited
to, banks, brokers, dealers, institutional investors and undertakings with a
treasury department, who or which trade or invest in securities in the conduct
of a business or profession.

     (6) No invitation to the public in the Cayman Islands to subscribe for or
purchase any of the Securities or Preference Shares may be made unless the
Company is, at the relevant time, listed on the Cayman Islands Stock Exchange.

                                      I-2
<PAGE>

                                                                       EXHIBIT A

     Cahill, Gordon & Reindel, U.S. counsel for Shire, shall furnish an opinion
pursuant to Section 7(b) in the following form:

                                    [to come]

                                      A-1
<PAGE>

                                                                       EXHIBIT B

     Slaughter and May, English counsel to Shire, shall furnish an opinion
pursuant to Section 7(c) in the following form:

                                    [to come]

                                      B-1
<PAGE>

                                                                       EXHIBIT C

     Tatjana May, General Counsel of Shire, shall furnish an opinion pursuant to
Section 7(d) in the following form:

     (i) As of July 23, 2001, Shire had been duly qualified as a foreign
corporation for the transaction of business and, to the best of such counsel's
knowledge, (a) was in good standing under the laws of each other jurisdiction in
which it owns or leases properties or conducts any business so as to require
such qualification, or (b) was subject to no material liability or disability by
reason of the failure to be so qualified in any such jurisdiction (such counsel
being entitled to rely in respect of the opinion in this clause upon opinions of
local counsel and in respect of matters of fact upon certificates of officers of
Shire, provided that such counsel shall state that they believe that both you
and they are justified in relying upon such opinions and certificates);

     (ii) To the best of such counsel's knowledge and other than as set forth in
the Offering Circular, there are no legal or governmental proceedings pending to
which Shire or any of its subsidiaries is a party or of which any property of
Shire or any of its subsidiaries is the subject which, if determined adversely
to Shire or any of its subsidiaries, would individually or in the aggregate have
a Material Adverse Effect; and, to the best of such counsel's knowledge, no such
proceedings are threatened or contemplated by governmental authorities or
threatened by others; and

     (iii) To the best of such counsel's knowledge, neither Shire nor any of its
subsidiaries is in violation of its Articles of Incorporation or By-laws or in
default in the performance or observance of any obligation, covenant or
condition contained in any indenture, mortgage, deed of trust, loan agreement,
lease or other agreement or instrument to which it is a party or by which it or
any of its properties may be bound, except for any such conflict, breach,
violation or default which would not have a Material Adverse Effect;

     (iv) Shire has an authorized capitalization as set forth in the Offering
Circular, and all of the issued shares of capital stock of Shire have been duly
and validly authorized and issued and are fully paid and non-assessable; and the
ordinary shares issuable in exchange for the Preference Shares have been duly
and validly authorized and reserved for issuance and, when issued and delivered
in accordance with the provisions of the Preference Shares and the Indenture
will be duly and validly issued and fully paid and non-assessable; and

     (v) To the best of such counsel's knowledge, the issue of the ordinary
shares upon exchange of the Preference Shares and Shire's execution and
compliance with all of the provisions of the Indenture, the Registration Rights
Agreement, the Guarantee, the Deposit Agreement and this Agreement and the
consummation of the transactions herein and therein contemplated will not
conflict with or result in a breach or violation of any of the terms or
provisions of, or constitute a default under, any indenture, mortgage, deed of
trust, loan agreement or other agreement or instrument known to such counsel to
which Shire or any of its subsidiaries is a party or by which Shire or any of
its subsidiaries is bound or to which any of the property or assets of Shire or
any of its subsidiaries is subject, except for any such conflict, breach,
violation or default which would not have a Material Adverse Effect.

                                      C-1
<PAGE>

                                                                       EXHIBIT D

     Maples and Calder Europe, Cayman Islands counsel for the Company, shall
deliver an opinion pursuant to Section 7(e) in the following form:

     We have acted as Cayman Islands legal advisers to Shire Finance Limited
(the "Issuer") in connection with its issue of US$350,000,000 (subject to over
allotment) 2% Senior Guaranteed Convertible Notes due 2011 (the "Notes")
unconditionally and irrevocably guaranteed by Shire Pharmaceuticals Group plc
(the "Guarantor") and convertible into Exchangeable Redeemable Preference Shares
in the Issuer (the "Preference Shares"). We are giving this opinion to you
pursuant to the purchase agreement (the "Purchase Agreement") dated 15 August,
2001 between the Issuer, the Guarantor, Bear, Stearns International Limited and
Goldman Sachs International and the other purchasers named therein (together,
the "Purchasers"). We understand that the Notes will be constituted by the
Indenture (as defined below).

     For the purposes of this opinion, we have reviewed only originals, copies
or final forms or drafts of the following documents:

          (a) the certificate of incorporation of the Issuer dated 19th July,
     2001 and the amended and restated memorandum and articles of association of
     the Issuer as adopted on [ ] August, 2001;

          (b) the register of directors and officers, the register of mortgages
     and charges and the register of members of the Issuer as maintained at its
     registered office in the Cayman Islands;

          (c) the minutes of the meetings of the board of directors of the
     Issuer held on [ ] and [ ] August 2001 and the corporate records of the
     Issuer maintained at its registered office in the Cayman Islands;

          (d) a certificate from a director of the Issuer dated [ ] August, 2001
     a copy of which is attached hereto (the "Director's Certificate");

          (e) the Purchase Agreement;

          (f) the offering circular (the "Offering Circular") dated [ ] August,
     2001 relating to the issue of the Notes;

          (g) the form of the Indenture (the "Indenture") between the Issuer,
     the Guarantor and the Trustee and including the form of the Rule 144A
     Global Note and the Regulation S Global Note set out in the Schedules
     thereto (together, "the Global Notes"); and

          (h) the form of the Registration Rights Agreement between the Issuer,
     the Guarantor and the Purchasers (the "Registration Rights Agreement").

                                       D-1
<PAGE>

     Save as aforesaid we have not been instructed to undertake and have not
undertaken any further enquiry or due diligence in relation to the transaction
the subject of this opinion and the following opinions are given only as to and
based on circumstances and matters of fact existing at the date hereof and of
which we are aware consequent upon the instructions we have received in relation
to the matter the subject of this opinion and as to the laws of the Cayman
Islands as the same are in force at the date hereof. In giving this opinion, we
have relied upon the completeness and accuracy (and assumed the continuing
completeness and accuracy as at the date hereof) of the Director's Certificate
without further verification and have relied upon the following assumptions,
which we have not independently verified:

          (i) The Purchase Agreement, the Indenture and the Registration Rights
     Agreement (collectively, the "Agreements") and the Notes (which expression
     includes, for the purposes of this opinion, the Global Notes) have been
     duly authorised, executed, delivered and (if appropriate) authenticated and
     registered by or on behalf of all relevant parties (other than the Issuer).

          (ii) The Agreements and the Notes are, or will be, legal, valid,
     binding and enforceable against all relevant parties in accordance with the
     laws of New York and all other relevant laws (other than, with respect to
     the Issuer, the laws of the Cayman Islands).

          (iii) The power, authority and legal right of all parties under all
     relevant laws and regulations (other than, with respect to the Issuer, the
     laws of the Cayman Islands) to enter into, execute and perform their
     respective obligations under the Agreements or to buy, hold or sell the
     Notes.

          (iv) The choice of the laws of New York as the governing law of the
     Agreements and the Notes has been made by all parties in good faith and
     would be regarded as a valid and binding selection which will be upheld by
     the courts of New York as a matter of the laws of New York and by all other
     courts under all other relevant laws (other than the laws of the Cayman
     Islands).

          (v) Copy documents or drafts of documents provided to us are true and
     complete copies of, or in the final forms of, the originals.

          (vi) The genuineness of all signatures, seals and initials.

          (vii) All conditions precedent contained in the Agreements have been
     satisfied or duly waived and there has been no breach of the terms of the
     Agreements at the date hereof.

          (viii) The Notes will be issued in accordance with the provisions of
     the Indenture.

          (ix) There is no contractual or other prohibition (other than as may
     arise by virtue of the laws of the Cayman Islands) binding on the Issuer or
     on any other party

                                       D-2
<PAGE>

     prohibiting it from entering into and performing its obligations under the
     Agreements or the Notes.

          (x) The Issuer is not a sovereign entity of any State and is not a
     subsidiary, direct or indirect of any sovereign entity or State.

          (xi) No invitation has been or will be made by or on behalf of the
     Issuer to the public in the Cayman Islands to subscribe for any of the
     Notes.

     The following opinions are given only as to matters of Cayman Islands law
and we have assumed that there is nothing under any other law that would affect
or vary the following opinions. Specifically we have made no investigation of
the laws of New York and we offer no opinion in relation thereto.

     Based upon the foregoing and subject to the qualifications set out below
and having regard to such legal considerations as we deem relevant, we are of
the opinion that:

          (i) The Issuer has been duly incorporated as an exempted company with
     limited liability for an unlimited duration and is validly existing under
     the laws of the Cayman Islands with full corporate power and authority to
     own its property and assets and to carry on its business in accordance with
     its memorandum and articles of association and to enter into and execute
     and perform its obligations under the Agreements and the Notes including
     the issue and offer of the Notes and the allotment and issue of the
     Preference Shares. The Amended and Restated Memorandum and Articles of
     Association of the Issuer dated [ ] August, 2001 have been validly adopted.

          (ii) The execution and delivery of the Agreements and the issue and
     offer of the Notes by the Issuer and the issue and allotment of the
     Preference Shares and the performance of its obligations thereunder have
     been duly authorised and approved by all necessary corporate action of the
     Issuer and do not violate, conflict with or result in a breach of any of
     the terms or provisions of its memorandum and articles of association or
     any law, public rule or regulation applicable to the Issuer in the Cayman
     Islands currently in force and do not violate, conflict with or result in a
     breach of any existing order or decree of any governmental authority or
     agency or any official body in the Cayman Islands.

          (iii) Each of the Agreements has been duly executed and delivered for
     and on behalf of the Issuer and constitutes a legal, valid and binding
     obligation of the Issuer enforceable in accordance with its terms except
     and in so far as such enforcement may be limited as hereinafter set forth.
     The Notes, when paid for, registered and issued in accordance with the
     Indenture, will constitute the legal, valid and binding obligations of the
     Issuer and, to the extent so enforceable as a matter of the proper
     governing law thereof, enforceable in accordance with their respective
     terms except and insofar as such enforcement may be limited as hereinafter
     set forth.

                                       D-3
<PAGE>

          (iv) Assuming the same to be the case as a matter of its governing law
     (which we have assumed is New York law) (i) the payment obligations under
     the Notes will constitute unsecured and unsubordinated obligations of the
     Issuer; and (ii) claims in respect of the Notes shall rank pari passu and
     without any preference among themselves with all other present and future
     unsecured and unsubordinated obligations of the Issuer, except for those
     obligations of the Issuer which are mandatorily preferred by law.

          (v) No authorisations, consents, orders, permissions or approvals are
     required from any governmental authorities or agencies or other official
     bodies in the Cayman Islands and no notice to or other filing with or
     action by any Cayman Islands governmental authority or regulatory body is
     required in connection with:

               (1)  the issue of the Offering Circular;

               (2)  the execution and delivery of the Agreements;

               (3)  the execution, authentication, issue or delivery of the
                    Notes;

               (4)  the performance of any obligation under the Notes or the
                    Agreements;

               (5)  the payment of the principal, premium (if any), interest or
                    any additional amount payable under the Notes; or

               (6)  the allotment and issue of the Preference Shares.

          (vi) It is not necessary to ensure the legality, validity,
     enforceability or admissibility in evidence of the Agreements or the Notes
     that any document be filed, recorded or enrolled with any governmental
     department, agency or other authority in the Cayman Islands. There is no
     requirement of Cayman Islands law that the Offering Circular should be
     filed, recorded or enrolled with any governmental department, agency or
     other authority in the Cayman Islands.

          (vii) No stamp duties or other similar taxes or charges are payable
     under the laws of the Cayman Islands in respect of the execution or
     delivery of the Agreements or the Notes or the performance or enforcement
     of any of them, unless they are executed in or thereafter brought within
     the jurisdiction of the Cayman Islands (e.g. for the purposes of
     enforcement) in which case stamp duty of (i) CI$2.00 (US$3) for each of the
     Agreements other than the Indenture and CI$100 (US$122) for the Indenture
     and (ii) 0.25% of the principal amount specified on the face of each Note
     up to a maximum of CI$250.00 (US$305) unless CI$500.00 (US$610) has been
     paid in respect of the entire issue of Notes, may be payable. An instrument
     of transfer in respect of a Note if executed in or brought within the
     jurisdiction of the Cayman Islands will be subject to a Cayman Islands
     stamp duty of CI$100.00 (US$122). Subject as aforesaid, a holder of a Note
     will not incur or become liable for any transfer or other similar taxes or
     charges under the laws of the Cayman Islands by reason of the acquisition,
     ownership, conversion or disposal of the

                                       D-4
<PAGE>

     Notes. No stamp duties or other similar taxes or charges are payable under
     the laws of the Cayman Islands in respect of the allotment or issue of the
     Preference Shares or the exchange thereof in accordance with the Articles
     of Association of the Issuer. Nominal Cayman Islands stamp duty will be
     payable in respect of any instrument of transfer of the Preference Shares
     if executed or brought within the Cayman Islands.

          (viii) There are currently no taxes or other charges or deductions
     payable (by withholding or otherwise) to the Cayman Islands Government or
     any taxing authority thereof either (i) on or by virtue of the execution,
     delivery, authentication (if appropriate) or enforcement of the Agreements
     or the Notes or (ii) on any payment of any nature to be made by the Issuer
     under any of the Agreements or the Notes. The Cayman Islands currently have
     no income, corporate or capital gains tax and no estate duty, inheritance
     tax or gift tax. There are currently no Cayman Islands taxes or other
     charges or deductions of any nature on gains realised on a sale, exchange,
     conversion, transfer or redemption of a Note.

          (ix) The choice of the laws of New York to govern the Agreements and
     the Notes will be upheld as a valid choice of law under the laws of the
     Cayman Islands and the courts of the Cayman Islands would uphold such
     choice of law in a suit on the Agreements or the Notes brought in the
     courts of the Cayman Islands, assuming it is so pleaded. An action against
     the Issuer in the Cayman Islands under the Agreements or the Notes could be
     instituted in the Grand Court, which has jurisdiction over the Issuer,
     without first having to obtain a judgment in respect of the Agreements or
     the Notes in a court of New York for any other relevant jurisdiction. In
     the event of any proceedings being brought in the Cayman Islands courts in
     respect of a monetary obligation expressed to be payable in a currency
     other than Cayman Islands dollars, a Cayman Islands court would give
     judgment expressed as an order to pay such currency or its Cayman Islands
     dollar equivalent at the time of payment or enforcement of the judgment.

          (x) The submission to the jurisdiction of the courts of New York, and
     the appointment of an agent to accept service of process in such
     jurisdiction, is legal, valid and binding on the Issuer.

          (xi) Although there is no statutory enforcement in the Cayman Islands
     of judgments obtained in New York courts, the courts of the Cayman Islands
     will recognise and enforce a judgment of a foreign court of competent
     jurisdiction without retrial on the merits based on the principle that a
     judgment of a competent foreign court imposes upon the judgment debtor an
     obligation to pay the sum for which judgment has been given provided that
     such judgment is final and conclusive, for a liquidated sum, not in respect
     of taxes or a fine or penalty, is not inconsistent with a Cayman Islands
     judgment in respect of the same matter, and was not obtained in a manner
     and is not of a kind the enforcement of which is contrary to the public
     policy of the Cayman Islands. A Cayman Islands court may stay proceedings
     if concurrent proceedings are being brought elsewhere. A foreign judgment
     may be final and conclusive even if subject to appeal. However, if
     appealable, a Cayman Islands court may stay enforcement until such appeal
     has been heard. A judgment

                                       D-5
<PAGE>

     with respect to a debt (including interest) which is lawfully due is not
     normally of a kind the enforcement of which the Cayman Islands courts would
     consider to be contrary to the public policy of the Cayman Islands.

          (xii) Based on our review of the Register of Writs and other
     Originating Process for the period since incorporation, there are no
     actions pending against the Issuer in the Grand Court of the Cayman Islands
     on [ ] August, 2001. A search at the Companies Registry in the Cayman
     Islands would not reveal any order or resolution for the winding up of the
     Issuer because under Cayman Islands law the records kept by the Registrar
     of Companies are not documents of public record. The enquiries referred to
     above which we have made at the Grand Court of the Cayman Islands have
     revealed no record of the presentation of any winding up petition in
     respect of the Issuer. We assume that there has been no change in this
     position since the date on which the enquiries were made.

          (xiii) None of the Purchasers, the Trustee or the holders of Notes or
     the Preference Shares will be treated as resident, domiciled or carrying on
     or transacting business or subject to taxation in the Cayman Islands or in
     violation of any law thereof solely by reason of the negotiation,
     preparation or execution of the Agreements or the issue of the Notes or the
     Preference Shares or the entering into of or the exercise of their rights
     or the performance of their obligations under the Agreements, the Notes or
     the Preference Shares.

          (xiv) None of the Purchasers, the Trustee or the holders of Notes will
     be required to be licensed, qualified, or otherwise entitled to carry on
     business in the Cayman Islands in order to enforce their respective rights
     under, or as a consequence of the execution, delivery and performance of
     the Agreements or the issue of the Notes.

          (xv) There is no exchange control legislation under Cayman Islands law
     and accordingly there are no exchange control regulations imposed under
     Cayman Islands law.

          (xvi) The taxation section in the Offering Circular under the heading
     "Cayman Islands Tax Considerations", so far as it relates to taxation
     within and from the Cayman Islands, is correct in all material respects.

          (xvii) In any legal proceedings taken in the Cayman Islands in
     relation to the Agreements or the Notes, the Issuer will not be entitled to
     claim for itself or any of its assets immunity from suit, execution,
     attachment or other legal process.

     This opinion is subject to the following qualifications and limitations:

     (5) The term "enforceable" as used above means that the obligations assumed
by the Issuer under the relevant instrument are of a type which the courts of
the Cayman Islands enforce.

                                       D-6
<PAGE>

It does not mean that those obligations will necessarily be enforced in all
circumstances in accordance with their terms. In particular:

          (f) enforcement may be limited by bankruptcy, insolvency, liquidation,
     reorganisation, readjustment of debts or moratorium or other laws of
     general application relating to or affecting the rights of creditors;

          (g) enforcement may be limited by general principles of equity - for
     example, equitable remedies such as specific performance may not be
     available, inter alia, where damages are considered to be an adequate
     remedy;

          (h) claims may become barred under the statutes of limitation or may
     be or become subject to defences of set-off, counterclaim, estoppel and
     similar defences;

          (i) where obligations are to be performed in a jurisdiction outside
     the Cayman Islands, they may not be enforceable in the Cayman Islands to
     the extent that performance would be illegal under the laws of that
     jurisdiction;

          (j) provisions, for example, for the payment of additional interest in
     certain circumstances, may be unenforceable to the extent a court of the
     Cayman Islands determines such a provision to be a penalty; and

          (k) enforcement may be limited by the principle of forum non
     conveniens or analogous principles notwithstanding any purported waiver of
     such principle by any of the parties.

          (6) With respect to winding up proceedings, Cayman Islands law may
     require that all claims or debts of the Issuer are converted into its
     functional currency of account at the exchange rate ruling at the date of
     commencement of the winding up.

     (7) A certificate, determination, calculation or designation of any party
to the Agreements as to any matter provided in any of the Notes or any of the
Agreements might be held by a Cayman Islands court not to be conclusive, final
and binding if, for example, it could be shown to have an unreasonable or
arbitrary basis or in the event of manifest error.

     (8) Pursuant to the Grand Court Rules, 1995, Order 62, rule 2, the Grand
Court of the Cayman Islands will award costs in litigation in accordance with
contractual provisions in this regard but we have reservations as to the way
this rule of court will apply in practice. While it is clear that the legal fees
and expenses incurred before judgment in enforcing a contract can be recovered
in accordance with the terms of that contract, it is likely that any legal fees
and expenses incurred after judgment will be recoverable, if at all, in
accordance with the rules laid down in the Grand Court (Taxation of Costs)
Rules, 1995.

                                       D-7
<PAGE>

     (9) We have reservations as to the ability of a party to obtain a judgment
for payment of interest at default rates (as against prescribed court rates)
after judgment in the courts of the Cayman Islands.

     (10) If any provision of a document is held to be illegal, invalid or
unenforceable, severance of such provision will be subject to the discretion of
the Cayman Islands courts notwithstanding any express contractual provisions in
this regard.

     (11) Any term of the Agreements may be amended orally by the parties
thereto notwithstanding provisions to the contrary contained therein.

     (12) Any obligations of the Issuer under the Agreements and the Notes to
any person or body connected with, resident in, incorporated in or constituted
under the laws of any country (an "Affected Country" presently including
Afghanistan, Angola, Ethiopia, Eritrea, Federal Republic of Yugoslavia, Haiti,
Iraq, Liberia, Libya, Rwanda, Serbia and Montenegro, Sierra Leone and Somalia);
or exercising public functions in any Affected Country or any person or body
controlled by any of the foregoing or any person acting on behalf of any of the
foregoing may be subject to restrictions or limitations.

     (13) In certain circumstances provisions in the Agreements or the Notes
that (i) the election of a particular remedy does not preclude recourse to one
or more others, or (ii) delay or failure to exercise a right or remedy will not
operate as a waiver of any such right or remedy, may not be enforceable.

     (14) Based on principles of privity of contract, any indemnity or other
provision of the Agreements or the Notes (not being in the form of a deed) which
is expressed to be in favour of persons who are not parties to the Agreements or
holders of Notes may not be enforceable by such persons in the absence of a
trust in their favour.

     (15) Whilst parties to an agreement may agree inter se that respective
rights and obligations take effect "as of" a date prior to the date of execution
and delivery, the rights of third parties, to the extent that the same may be
available thereunder, only take effect from the date of actual execution and
delivery.

     (16) Entries must be made in the register of mortgages and charges of the
Issuer in respect of all mortgages and charges created by the Issuer under any
of the Agreements in order to comply with the requirements of the Companies Law
(2001 Second Revision) of the Cayman Islands. Failure by the Issuer to comply
with this requirement does not operate to invalidate any mortgage or charge,
though it may be in the interests of the secured parties that the Issuer should
comply with the statutory requirements.

     (17) A Cayman Islands court may set aside transactions which are not
entered into on behalf of a company bona fide and in its interests and where
another party to the transaction exhibits the requisite bad faith. In
circumstances where the court finds that the directors of a

                                       D-8
<PAGE>

company have acted in breach of their fiduciary duties to the company, the court
may find such directors liable in damages for loss sustained by the company or
its creditors as a result.

     (14) The irrevocable appointment of an agent for service of process may, as
between the appointor and the agent, be revoked by the appointor unless given to
secure (i) a proprietary interest of the agent or (ii) the performance of an
obligation owed to the agent.

     (15) Currency indemnity provisions, so far as we are aware, have not been
tested in the Cayman Islands courts and may not be effective in all
circumstances.

     (16) We express no opinion in the event that the Issuer owns the Notes.

     Except as specifically stated herein, we make no comment with respect to
any representations and warranties which may be made by or with respect to the
Issuer in any of the Agreements, the Offering Circular or otherwise with respect
to the commercial terms of the transactions the subject of this opinion.

                                      D-9
<PAGE>

                                                                        ANNEX II

     Pursuant to Section 7(f) of the Purchase Agreement, Ernst & Young,
accountants to Shire, shall furnish letters to the Purchasers to the effect
that: [to come]

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