Document:

<PAGE>

                                                                   Exhibit 10.42

                                AMENDMENT NO. 1
                                      TO
                                DISCOVERWORKSTM
                    DRUG DISCOVERY COLLABORATION AGREEMENT
                              DATED JULY 7, 2000

         THIS AMENDMENT NO. 1 TO DISCOVERWORKSTM DRUG DISCOVERY COLLABORATION
AGREEMENT DATED JULY 7, 2000 (this "Amendment"), is made as of May 16, 2001 by
and between 3-Dimensional Pharmaceuticals, Inc., a Delaware corporation having
its principal place of business at Eagleview Corporate Center, 665 Stockton
Drive, Suite 104, Exton, PA 19341 ("3DP"), and Bristol-Myers Squibb Company, a
Delaware corporation having its principal place of business at Route 206 &
Province Line Road, P.O. Box 4000, Princeton, New Jersey 08543 ("BMS"). 3DP and
BMS may be referred to herein as a "Party" or, collectively, as the "Parties."

WHEREAS, 3DP and BMS are parties to that certain DiscoverWorksTM Drug Discovery
Collaboration Agreement dated as of July 7, 2000 (the "Agreement") pursuant to
which the parties are collaborating on the identification of Initial Hits,
Improved Hits, Program Lead Compounds and Pre-Clinical Lead Compounds (all as
defined in the Agreement) active against selected targets, and suitable, if
required, for medicinal chemistry optimization, that may be developed and
commercialized by BMS;.

WHEREAS, the Parties desire to amend the Agreement to include certain additional
libraries of compounds that have been and may be used in the screening being
conducted pursuant to the Research Program (as defined in the Agreement).

     NOW, THEREFORE, in consideration of the various promises and undertakings
set forth in this Amendment, the Parties agree to amend the Agreement as
follows:

1.   Section 1.5A. New Section 1.5A shall be added to read in its entirety as
     follows:

     "1.5A     "BMS Compound Library" means the sample compound library or any
               subset thereof, comprised of [**] as of the Effective Date, or
               [**] at any time thereafter, and which comprises [**] compounds
               and [**] products. While the individual [**] in the BMS Compound
               Library are not [**], the collection itself, and the list of [**]
               compounds included in the collection, are "Confidential
               Information" of BMS."

2.   Section 1.21. Section 1.21 shall be amended to read in its entirety as
     follows:

     "1.21     "Initial Hit" means a compound in the 3DP Probe Library, the BMS
               Compound Library or the 3DP [**] Probe Library that [**], as
               measured using ThermoFluor(R) Technology."

                                      -1-
**Certain portions of this exhibit have been omitted based upon a request for
confidential treatment that has been filed with the Commission. The omitted
portions have been filed separately with the Commission.
<PAGE>

3.   Section 1.41. Section 1.41 shall be amended by adding the phrase ", as it
     exists from time to time," after "3DP's virtual compound library" and
     before "from which 3DP Probe Libraries".

4.   Section 1.47. Section 1.47 shall be amended by adding the phrase ", as it
     exists from time to time," after "small molecule chemical compounds" and
     before "that have been synthesized by 3DP".

5.   Section 1.47A. New Section 1.47A shall be added to read in its entirety as
     follows:

     "1.47A    "3DP [**] Probe Library" means the sample compound library or any
               subset thereof, comprised of [**] as of the Effective Date, or
               [**] at any time thereafter, and which have [**] against a known
               target or class or targets, and may be useful to identify the
               [**]. While the individual [**]in the 3DP [**] Probe Library are
               not [**], the collection itself, and the list of [**] compounds
               included in the collection, are "Confidential Information" of
               3DP."

6.   Section 2.2. Section 2.2 shall be amended to read in its entirety as
     follows:

     "2.2      Initial Screening and Initial Hits.

               2.2.1        Depending on the nature and source of each Target,
                            3DP shall screen the Target against a screening
                            library, created from (i) the 3DP Probe Library,
                            totaling no more than [**] compounds per Target that
                            are selected by [**], to identify Initial Hits;
                            however, 3DP shall not be required to screen [**]
                            pursuant to Section 2.2.1(i) and (ii). The JSMC may
                            ask 3DP to screen [**] from the 3DP Probe Library or
                            the BMS Compound Library if [**].

               2.2.2        Depending on the nature and source of each Target,
                            3DP shall screen the Target against a screening
                            library, created from the 3DP [**] Probe Library,
                            totaling no more than [**] compounds per Target that
                            are selected by [**], to identify Initial Hits or
                            [**]. The JSMC may ask 3DP to screen [**] from the
                            3DP Probe Library or the BMS Compound Library based
                            on the results from screening of the [**].

               2.2.3        Any additional screening requested as provided in
                            Sections 2.2.1 or 2.2.2, if any, together with the
                            screening to be conducted pursuant to such Sections,
                            shall be subject to the overall disposition of
                            Research Program FTE resources as determined by the
                            JSMC, and 3DP's screening capacity available to the
                            Research Program."

                                      -2-
**Certain portions of this exhibit have been omitted based upon a request for
confidential treatment that has been filed with the Commission. The omitted
portions have been filed separately with the Commission.
<PAGE>

7.     Section 3.6. The first sentence of Section 3.6 shall be amended by adding
       the phrase ", including without limitation any compounds from the 3DP
       Probe Library, the 3DP [**] Probe Library or the BMS Compound Library"
       after "certain biological materials or chemical compounds" and before
       "(collectively, the "Substances")."

8.     Section 4.2.11. Section 4.2.11 shall be added to read in its entirety as
       follows:

              "4.2.11     Reviewing results from the screening of the 3DP [**]
              Probe Library in connection with selecting the additional
              compounds from the 3DP Probe Library or the BMS Compound Library
              to be screened by 3DP."

9.     Section 6.1.1. Section 6.1.1 shall be amended to read in its entirety as
       follows:

              "6.1.1      3DP shall retain its ownership rights in the 3DP Probe
              Library and the Synthetically Accessible Library and shall have
              ownership rights as to BMS in any Focused Library developed by 3DP
              pursuant to this Agreement. 3DP shall retain whatever rights, if
              any it may have in the 3DP [**] Probe Library. BMS shall retain
              its ownership rights of the [**] compounds contained in the BMS
              Compound Library, and shall retain whatever rights, if any, it may
              have to the [**] compounds contained in the BMS Compound Library."

10.    Section 6.1.3. Section 6.1.3 shall be amended to read in its entirety as
       follows:

              "6.1.3      In the event that [**] based on [**] as part of the
              Research Program where such [**], then BMS shall have [**], and
              shall have [**] in such compounds; however, BMS shall not [**]
              against the [**] pursuant to this Agreement."

11.    Section 6.1.4. New Section 6.1.4 shall be added to read in its entirety
       as follows:

              "6.1.4      In the event that [**] based on [**] as part of the
              Research Program where such [**], then BMS shall have [**],
              including the [**]; however, BMS shall not [**] against the [**]
              pursuant to this Agreement and from which such [**]."

12.    Section 6.3. Section 6.3 shall be amended to read in its entirety as
       follows:

       "6.3   Ownership of Initial Hits.

                                      -3-
**Certain portions of this exhibit have been omitted based upon a request for
confidential treatment that has been filed with the Commission. The omitted
portions have been filed separately with the Commission.
<PAGE>

              6.3.1  3DP shall retain any proprietary rights, title and interest
                     in and appurtenant to the Initial Hits identified from the
                     [**] that it may have had; however, [**].

              6.3.2  BMS shall retain any proprietary rights, title and interest
                     in and appurtenant to the Initial Hits identified from the
                     [**] that it may have had; however, [**].

              6.3.3  In order for the activities in Section 2.3 to be
                     undertaken, the JSMC may review data produced in the course
                     of the Research Program associated with such Initial Hits."

13.    Section 6.4. Section 6.4 shall be amended to read in its entirety as
       follows:

       "6.4   Ownership of Improved Hits.

              6.4.1  3DP shall retain any proprietary rights, title and interest
                     in and appurtenant to Improved Hits developed from Initial
                     Hits identified from the [**] that it may have had;
                     provided, however, BMS shall have an exclusive, worldwide
                     license, as to 3DP, with the right to sublicense, to
                     develop, make, have made, use, and commercialize such
                     Improved Hits against the specified Target of such Improved
                     Hits. Such license, and any sublicenses thereunder, shall
                     terminate, and 3DP shall regain its original rights, when
                     BMS ceases developing or commercializing any such Improved
                     Hit, or any Program Lead Compound or Pre-Clinical Lead
                     Compound developed from such Improved Hit against the
                     specified Target.

              6.4.2  BMS shall retain any proprietary rights, title and interest
                     in and appurtenant to Improved Hits developed from Initial
                     Hits identified from [**] that it may have had."

14.    Section 6.5. Section 6.5 shall be amended to read in its entirety as
       follows:

       "6.5   Ownership of Program Lead Compounds and Pre-Clinical Lead
       Compounds.

              6.5.1  All right, title and interest in and appurtenant to each
                     Program Lead Compound and each Pre-Clinical Lead Compound
                     developed from Initial Hits identified from the [**] shall
                     be owned, as to 3DP, by BMS; provided, however, that if
                     such a Program Lead Compound or a Pre-Clinical Lead
                     Compound, as the case may be, is developed to its
                     respective status by 3DP, then 3DP shall have ownership
                     rights, as to BMS, to such Program Lead Compound or such

                                      -4-
**Certain portions of this exhibit have been omitted based upon a request for
confidential treatment that has been filed with the Commission. The omitted
portions have been filed separately with the Commission.
<PAGE>

                     Pre-Clinical Lead Compound, and BMS shall have an
                     exclusive, worldwide license, as to 3DP, with right to
                     sublicense (subject to the provisions of Section 6.6), to
                     develop, make, have made, use, and commercialize such
                     Program Lead Compound or such Pre-Clinical Lead Compound.

              6.5.2  All right, title and interest in and appurtenant to each
                     Program Lead Compound and each Pre-Clinical Lead Compound
                     developed from Initial Hits identified from the [**] shall
                     be owned, as to 3DP, by BMS."

15.    Section 6.6. Section 6.6 shall be amended by adding the phrase "
       identified from the [**]" after "Pre-Clinical Lead Compound" and before
       ", BMS agrees,".

16.    Defined Terms. All terms used in this Amendment and not otherwise defined
       in this Amendment shall have the meanings assigned to such terms in the
       Agreement.

17.    Effective Date of Amendment. This Amendment shall take retroactive effect
       as of July 7, 2000.

18.    Effect of Amendment. Except as amended in this Amendment, in all other
       respects the Agreement shall remain in full force and effect and shall be
       unaffected by this Amendment.

                                      * * *

                                      -5-
**Certain portions of this exhibit have been omitted based upon a request for
confidential treatment that has been filed with the Commission. The omitted
portions have been filed separately with the Commission.
<PAGE>

         IN WITNESS WHEREOF, each of the Parties has caused this Amendment to be
executed by its duly authorized representative as of the date first above
written, each copy of which shall for all purposes be deemed to be an original.

                                       3-DIMENSIONAL PHARMACEUTICALS, INC.

                                       By:      /s/ David C. U'Prichard
                                                -----------------------
                                                David C. U'Prichard, Ph.D.
                                                Chief Executive Officer

                                       BRISTOL-MYERS SQUIBB COMPANY

                                       By:      /s/ David Floyd
                                                ---------------
                                       Name:    David Floyd
                                       Title:   V.P. Chemistry

                                      -6-
**Certain portions of this exhibit have been omitted based upon a request for
confidential treatment that has been filed with the Commission. The omitted
portions have been filed separately with the Commission.<PAGE>

                                 LEASE AGREEMENT
                                 ----- ---------

BY AND BETWEEN:

                       Cedar Brook Corporate Center, L.P.

                                                                      "Landlord"

                                     - and -

                       3 Dimensional Pharmaceuticals, Inc.

                                                                       "Tenant"

PREMISES:         8 Clarke Drive
                  Cranbury, NJ 08512

DATED: June 14, 2001

                                       1
<PAGE>

                                TABLE OF CONTENTS
                                -----------------

1.       LEASED PREMISES.......................................................1
         ---------------

2.       TERM OF LEASE.........................................................2
         -------------

3.       CONSTRUCTION OF THE TENANT IMPROVEMENTS...............................2
         ---------------------------------------

4.       RENT..................................................................6
         ----

5.       PARKING AND USE OF EXTERIOR AREA......................................7
         --------------------------------

6.       USE...................................................................8
         ---

7.       REPAIRS AND MAINTENANCE...............................................8
         -----------------------

8.       COMMON AREA EXPENSES, TAXES AND INSURANCE............................10
         -----------------------------------------

9.       SIGNS................................................................13
         -----

10.      ASSIGNMENT AND SUBLETTING............................................13
         -------------------------

11.      FIRE AND CASUALTY....................................................14
         -----------------

12.      COMPLIANCE WITH LAWS, RULES AND REGULATIONS..........................16
         -------------------------------------------

13.      INSPECTION BY LANDLORD...............................................18
         ----------------------

14.      DEFAULT BY TENANT....................................................19
         -----------------

15.      LIABILITY OF TENANT FOR DEFICIENCY...................................21
         ----------------------------------

16.      NOTICES..............................................................21
         -------

17.      NON-WAIVER BY LANDLORD...............................................22
         ----------------------

18.      RIGHT OF TENANT TO MAKE ALTERATIONS AND IMPROVEMENTS.................22
         ----------------------------------------------------

19.      NON-LIABILITY OF LANDLORD............................................22
         -------------------------

20.      RESERVATION OF EASEMENT..............................................23
         -----------------------

21.      STATEMENT OF ACCEPTANCE..............................................23
         -----------------------
<PAGE>

22.      FORCE MAJEURE........................................................23
         -------------

23.      STATEMENTS BY LANDLORD AND TENANT....................................23
         ---------------------------------

24.      CONDEMNATION.........................................................24
         ------------

25.      LANDLORD'S REMEDIES..................................................24
         -------------------

26.      QUIET ENJOYMENT......................................................25
         ---------------

27.      SURRENDER OF PREMISES................................................25
         ---------------------

28.      INDEMNITY............................................................26
         ---------

29.      BIND AND CONSTRUE CLAUSE.............................................26
         ------------------------

30.      INCLUSIONS...........................................................27
         ----------

31.      DEFINITION OF TERM "LANDLORD"........................................27
         -----------------------------

32.      COVENANTS OF FURTHER ASSURANCES......................................27
         -------------------------------

33.      COVENANT AGAINST LIENS...............................................27
         ----------------------

34.      SUBORDINATION........................................................28
         -------------

35.      EXCULPATION OF LANDLORD..............................................28
         -----------------------

36.      NET RENT.............................................................28
         --------

37.      SECURITY.............................................................28
         --------

38.      BROKERAGE............................................................29
         ---------

39.      LATE CHARGES.........................................................29
         ------------

40.      PRESS RELEASES.......................................................29
         --------------

41.      WAIVER OF JURY TRIAL.................................................29
         --------------------

42.      LAWS OF NEW JERSEY...................................................30
         ------------------

43.      OPTION TO RENEW......................................................30
         ---------------
<PAGE>

                                                                   Exhibit 10.43

          AGREEMENT, made June 14, 2001, between Cedar Brook Corporate Center,
L.P., 1000 Eastpark Blvd., Cranbury, New Jersey 08512, "Landlord"; and 3
Dimensional Pharmaceuticals, Inc., 8 Clarke Drive, Cranbury, NJ 08512, "Tenant".

                             W I T N E S S E T H:
                             - - - - - - - - - -

          WHEREAS, the Landlord intends to lease to the Tenant a portion of 8
Clarke Drive, Cranbury, NJ 08512 ("Building") constituting a portion of the
office/industrial park known as Cedar Brook Corporate Center ("Office Park");
and

          WHEREAS, the parties hereto wish to mutually define their rights,
duties and obligations in connection with the said lease;

          NOW THEREFORE, in consideration of the promises set forth herein, the
Landlord leases unto the Tenant and the Tenant rents from the Landlord the
leased premises described in Paragraph 1, and the Landlord and Tenant do hereby
mutually covenant and agree as follows:

     1.   LEASED PREMISES
          ---------------

          The leased premises shall consist of 10,497 rentable square feet of
office space, 5,698 square feet of which is already constructed and which Tenant
accepts in its "as is" condition and 4,799 square feet of which the Landlord
shall construct for Tenant ("Leased Premises"). The Leased Premises, all as more
particularly identified on the plan attached hereto as Schedule "A", shall be
measured from the outside of exterior walls to the center line of common walls,
and shall include all improvements to be constructed thereon by the Landlord for
the use of the Tenant, and all

Initial: Landlord
         Tenant
Lease Version Date: 5-31-01

<PAGE>

easements, tenements, appurtenances, hereditaments, rights and privileges
appurtenant thereto, and any and all fixtures and equipment which are to be
installed in said Building by the Landlord for the use of the Tenant in its
occupancy of the Leased Premises. Tenant shall also have the right to use all
common areas of the Office Park in a similar manner as other Office Park
tenants.

     2.   TERM OF LEASE
          -------------

          The term of the Lease shall be coincident with the term of that
certain sublease of 31,423 square feet of space in the Building between Tenant
and Advanced Medicine, Inc., which expires on May 31, 2007. The Commencement
Date of this Lease shall mean the first day of the next succeeding month
following the occurrence of all of the following conditions:

          (a)  Landlord shall have achieved Substantial Completion (as that term
is defined hereafter); and

          (b)  Water, sewer, gas, and electricity utility service shall be
available to the Leased Premises.

          The Substantial Completion date is projected to be August 15, 2001.
However, such date shall be contingent upon Landlord receiving, reviewing and
approving the Plans (as that term is defined hereafter), and upon the vacation
of the Leased Premises by its existing tenant whose lease expires on June 30,
2001

     3.   CONSTRUCTION OF THE TENANT IMPROVEMENTS
          ---------------------------------------

          3.1  The Landlord shall provide all necessary labor and materials and
perform all of the work required for the construction of that portion of the
Leased Premises comprising 4,799 square feet including machinery, fixtures and
equipment to be constructed and other improvements to be installed by Landlord
in the Leased Premises in order to ready the same for Tenant's occupancy

Initial: Landlord
         Tenant
Lease Version Date: 5-31-01

                                       2
<PAGE>

(the "Tenant Improvements"), all as shown on the Plans as defined herein.
Tenant's designated representative for all work pertaining to the Tenant
Improvements shall be Jason Van Buren (hereinafter the "Representative").

          3.2  The Landlord shall supervise and direct the work on the Tenant
Improvements using Landlord's best skill and attention, and Landlord shall be
solely responsible for all construction means, methods, techniques, sequences
and procedures and for coordinating all portions of the work on the Tenant
Improvements. Landlord shall use its best efforts to cause the Tenant
Improvements to be carried forward expeditiously so as to achieve Substantial
Completion of the Leased Premises on or before July 1, 2001, or as soon
thereafter as possible. Landlord shall be responsible for initiating,
maintaining and supervising all safety precautions and programs in connection
with performance of the Tenant Improvements.

           3.3  Landlord warrants to the Tenant that all materials and equipment
incorporated in the Tenant Improvements will be new unless otherwise specified,
and that all work on the Tenant Improvements will be of good quality, free from
known faults and defects, and in substantial conformity with the Plans.

          3.4  (a) Landlord shall complete the construction of the Leased
Premises in a good and workmanlike manner and in substantial accordance with
plans and specifications ("Plans") to be prepared by Bala Consulting Engineers,
Inc. The Plans shall be provided to Landlord on or before June 30, 2001. In the
event Tenant fails to deliver the Plans to Landlord by said date, and such
failure delays the projected date of Substantial Completion then Tenant shall be
obligated to pay rent to Landlord for as many days prior to the date of
Substantial Completion as Tenant was late in providing the Plans. The Plans
shall be in sufficient detail to permit Landlord to apply for a

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       3
<PAGE>

building permit for the Tenant Improvements (which Landlord shall promptly do),
and to prepare a draft construction budget for the construction of the Tenant
Improvements (the "Construction Budget"). The Construction Budget shall set
forth the lump sum amount payable by Tenant to Landlord for the construction of
the Tenant Improvements, which amount shall include Landlord's standard mark-up
for general conditions (2%) times overhead (10%) times profit (7%), for a total
mark-up of 20%. The only exception to the lump sum amount shall be the actual
fees charged by the Township of Cranbury for construction permits and the
Council on Affordable Housing ("COAH") fee in connection with the Tenant
Improvements, both of which will not be determined by the municipality until
after the Landlord applies for the construction permits and shall be paid by
Tenant as set forth hereafter. After receipt of the draft construction budget,
Tenant shall give written notice to Landlord within 5 business days as to
whether or not it is acceptable. If the Tenant accepts the draft construction
budget during the 5 business day period then that shall be the budget for the
Tenant Improvements ("Construction Budget"). If Tenant does not accept the draft
construction budget during such 5 business day period, then the parties agree to
negotiate in good faith to reach an agreement on a budget for the Tenant
Improvements. In the event no agreement can be reached within a further 15 day
period, then either party may terminate this Lease.

               (b) A complete set of the agreed upon Plans, and the agreed upon
Construction Budget, shall be initialed by and distributed to Landlord and
Tenant. Neither the Construction Budget nor the Plans shall be changed or
altered in any way except by change order approved in writing by Landlord,
Architect and Tenant ("Change Order"). Each and every Change Order shall state
whether the change will entail a delay in the date of Substantial Completion.
Any approved delay to the date of Substantial Completion shall not delay the
commencement date for the

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       4
<PAGE>

payment of rent. All Change Orders shall be valid and binding upon Landlord and
Tenant only if authorized by written Change Order signed prior to commencement
of the work on the Tenant Improvements reflected thereby. The cost or credit to
the Tenant due to any Change Order shall be determined per the terms of such
Change Order. The Landlord shall have the right to substitute any materials and
equipment required by the Plans, with materials and equipment of equal or better
quality and standard, provided said substitutions conform with applicable
building codes and are the subject of a Change Order.

          3.5  (a) The Landlord may secure and advance payment for the
construction permits and for all other permits and governmental fees, licenses
and inspections necessary for the proper execution and completion of the Tenant
Improvements, and for the COAH fee. Tenant shall pay such amounts to Landlord
not later than 10 business days after receipt of an invoice therefor. Landlord
shall not, however, be responsible for securing any environmental or operating
permits or certifications which are required in order for Tenant to actually
conduct its business.

               (b) Tenant shall be responsible for providing Landlord with, and
bearing the cost of, sufficient copies of the Plans, as Landlord determines are
necessary, in order to obtain the permits and efficiently manage the
construction of the Leased Premises. In the event any Change Orders are required
during construction, Tenant shall be responsible for all costs related to the
preparation and reproduction of plans therefore. After construction is complete,
Tenant shall be responsible for all costs related to the reproduction of "as
built" plans. In all instances where plans are required, Tenant shall provide
Landlord with a reproducable set.

               (c) Tenant shall receive a construction allowance (the
"Construction Allowance") equal to $15.00 per square foot multiplied by 4,799
square feet of space ($71,985) in

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       5
<PAGE>

which Landlord will construct the Tenant Improvements. Any cost in excess of
such allowance shall be the responsibility of Tenant ("Tenant's Cost Share").
Upon approval of the Final Construction Budget, Tenant shall immediately pay to
Landlord, prior to the Landlord's commencement of work on Tenant Improvements, a
sum equal to 50% of Tenant's Cost Share. Upon Substantial Completion of Tenant
Improvements, Tenant shall immediately pay to Landlord a sum equal to the
remaining balance of Tenant's Cost Share. In the event Tenant fails to pay to
Landlord, upon approval of the Construction Budget a sum equal to 50% of
Tenant's Cost Share, Landlord shall not be obligated to commence work on the
Tenant Improvements for the Leased Premises, and such failure to pay shall not
delay the Commencement Date of this Lease or any of Tenant's obligations
hereunder including, without limitation, Tenant's obligation to pay all rent. In
the event that Tenant fails to pay to Landlord, upon Substantial Completion of
the Tenant Improvements for the Premises, a sum equal to the remaining cost of
Tenant's Cost Share, along with the COAH fee and construction permit fees, such
failure shall constitute a default under this Lease; and Tenant shall not be
permitted to occupy the Leased Premises; and Landlord shall be entitled to all
rights and remedies available hereunder, at law or in equity, or otherwise,
which rights shall be cumulative. All sums so owing to Landlord shall constitute
Additional Rent and shall be subject to the imposition of late charges as
provided in this Lease.

               (d) Tenant shall be responsible for the design and installation
of its own phone, data, communication, fire alarm and security systems, which
systems shall be installed in a manner not to interfere with Landlord's
construction efforts.

               (e) Apart from extensions of time for delays and the commencement
date for the payment of rent as hereinbefore provided, no payment or allowance
of any kind shall be

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       6
<PAGE>

claimed by or made to the Landlord as compensation for damages on account of
hindrance or delay from any cause in the Substantial Completion of the Tenant
Improvements whether such hindrance or delay be avoidable or unavoidable,
anything in this Agreement inconsistent herewith or to the contrary
notwithstanding.

                   (f) During construction of Tenant Improvements, a
representative of Tenant shall inspect the site no less frequently than once a
week and verify and agree that the work in progress has been completed in a
manner acceptable to both Landlord and Tenant.

               3.6 The Tenant Improvements shall be commenced upon approval by
governmental entities having jurisdiction therefor and, subject to authorized
adjustments, Substantial Completion is projected to be achieved on or about
August 15, 2001. As used herein the term "Substantial Completion" shall mean
that the Leased Premises have been built and completed in substantial conformity
with the Plans, and a temporary or permanent certificate of occupancy or a
temporary or permanent certificate of acceptance ("CO/CA") has been issued
permitting Tenant to use and occupy the Leased Premises, even though minor
details, adjustments or punch list items which shall not materially impair
Tenant's use and enjoyment of the Leased Premises may not have been finally
completed, but which work Landlord agrees shall be diligently pursued to final
completion. Tenant shall allow Landlord and its contractors to enter the Leased
Premises during normal working hours after issuance of the CO/CA to complete
remaining minor work or punch list items. It is agreed that for the purpose of
this Lease, wherever and whenever the term Substantial Completion is used, it
shall not include items of maintenance, service, punch list, or guarantee.

          3.7  Immediately prior to occupancy of the Leased Premises by the
Tenant, the Tenant and Landlord shall jointly inspect the Tenant Improvements in
order to determine and record their

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       7
<PAGE>

condition and to prepare a comprehensive list of items that have not been
completed (or which have not been correctly or properly completed) in conformity
with the Plans and which are to be completed or corrected by Landlord ("Punch
List Items"); and Landlord thereafter shall proceed promptly to complete and
correct all Punch List Items. Failure to include an item on such list does not
alter the responsibility of Landlord to complete all Tenant Improvements in
accordance with the Plans. Occupancy and use of the Leased Premises by Tenant
shall not constitute acceptance of Punch List Items not complying with the
requirements of the Plans.

     3.8 If, within one year after the date of Substantial Completion any of the
Tenant Improvements is found to be not in accordance with the requirements of
the Plans, Landlord shall correct said items promptly after receipt of written
notice from Tenant. Landlord's obligation under this Subsection shall survive
Tenant's occupancy of the Leased Premises. Tenant shall give Landlord notice
promptly after discovery of any deficient condition.

     4.   RENT
          ----

          4.1  Tenant shall pay, as rent for the Leased Premises, the
following:

               (a)  During the first 5 years of the term, an estimated annual
base rent per square foot of $15.75, for an aggregate annual base rent of
$165,327.75 ("Base Rent"), payable monthly in the sum of $13,777.31.

               (b)  During the remainder of the term, the Base Rent shall
increase by 15%.

               (c)  If the date of Substantial Completion occurs on a day other
than the first day of a month, rent from such day until the first day of the
following month shall be prorated (at a rate of 1/30th of the monthly rent per
day). During said period of partial monthly occupancy,

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all other terms and conditions of this Lease shall apply. All payments assume
rentable square footage of 10,497 square feet.

          4.2  Tenant shall pay as Additional Rent its proportionate share of
the taxes and any other charges allocated amongst the tenants. Tenant's
Proportionate Share shall be adjusted as of each first day of January during the
term, based on the relationship between the gross square footage leased to
Tenant and the gross square footage of building construction completed and
initially occupied in the Office Park as of such first day of January. Tenant's
Proportionate Share shall be adjusted over time as additional space is
constructed in the office/industrial park.

          4.3  The annual Base Rent shall be payable in advance in equal monthly
installments on the first day of each calendar month. Tenant covenants to pay
the Base Rent and Additional Rent in lawful money of the United States which
shall be legal tender for the payment of all debts, public and private, at the
time of payment. Such rent shall be paid to Landlord at its office address
hereinabove set forth, or at such other place as Landlord may, from time to
time, designate by notice to Tenant.

          4.4  The Base Rent and Additional Rent shall be payable by Tenant
without any set-off or deduction of any kind or nature whatsoever and without
notice or demand; and all Additional Rent under this Lease shall constitute rent
payable hereunder. The sum of all increases required to be paid as Additional
Rent, and/or increases in Base Rent in accordance with this Lease, shall be paid
to Landlord within 10 days following the giving of notice hereof by Landlord of
such increases.

     5.   PARKING AND USE OF EXTERIOR AREA
          --------------------------------

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          The Tenant shall have the right to use parking spaces on a
non-exclusive basis in common with other tenants of the Building. Landlord
reserves the right to allocate specific parking spaces if it chooses. The
Landlord and Tenant mutually agree that they will not block, hinder or otherwise
obstruct the access driveways and parking areas so as to impede the free flow of
vehicular traffic on the property. In connection with the use of the loading
platforms, if any, Tenant agrees that it will not use the same so as to
unreasonably interfere with the use of the access driveways and parking areas.
Tenant shall not store trailers or other vehicles on any portion of the access
driveways or parking areas, and may not utilize any portion of the land outside
of the Leased Premises for any purpose unless consented to in advance by
Landlord.

     6.   USE
          ---

          The Tenant covenants and agrees to use and occupy the Leased Premises
for office, general laboratory, manufacturing, marketing, pharmaceutical and
bio-technical research and development, or any combination of the foregoing
normally undertaken by a pharmaceutical company, which uses are expressly
subject to all applicable zoning ordinances, rules and regulations of any
governmental instrumentalities, boards or bureaus having jurisdiction thereof.
Tenant's use of the Leased Premises shall not interfere with the peaceable and
quiet use and enjoyment by other tenants at their respective leased premises
located at the Building or in the Office Park, nor shall Tenant's activities
cause Landlord to be in default under its leases with such other tenants.

     7.   REPAIRS AND MAINTENANCE
          -----------------------

          7.1  Tenant shall generally maintain and repair the Leased Premises,
in a good and workmanlike manner, and shall, at the expiration of the term,
deliver the Leased Premises in good order and condition, damages by fire or
casualty, the elements and ordinary wear and tear excepted.

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Tenant covenants and agrees that it shall not cause or permit any waste, damage
or disfigurement to the Leased Premises, or any overloading of the floors.
Tenant shall maintain and make all repairs to the floor surface, plumbing and
electrical systems including all ballasts and fluorescent fixtures located
within the Leased Premises, and the entire HVAC system, unless the repair is the
result of the negligence of Landlord, its agents, contractors, employees,
tenants or invitees. Landlord shall be responsible for repairs necessary to the
roof, foundation, exterior and load-bearing walls and other structural elements,
and electric, plumbing and other Building systems to the point where they enter
the Leased Premises, unless, and to the extent, the repair is necessitated by
negligence of Tenant, or its agents, employees or contractors, and the cost
thereof is not covered by Landlord's insurance, or the insurance Landlord is
required to carry under this Lease, (without taking into account any deductible)
whichever is greater. Repairs and replacements shall be made within a reasonable
time after Landlord receives notice or has actual knowledge of the need for such
repair or replacement.

          7.2  The Tenant shall, at its own cost and expense, pay all utility
meter and service charges, including gas and electric services used by the
Tenant in the Leased Premises. Landlord shall have the option to install, at its
own cost, a separate water meter and invoice Tenant directly for its water
usage. The Tenant agrees to maintain all leased areas at a minimum temperature
of 45 degrees, excluding cold rooms on other rooms specifically designed for a
lower temperature, to prevent the freezing of domestic water and sprinkler
pipes, provided that Tenant shall not be responsible if gas or electrical
service to the Building has been interrupted for a reason not caused by Tenant.
Tenant shall not store any items outside the Leased Premises, and shall deliver
its garbage and recyclables to the central receiving area on the lot. Tenant
shall dispose of all hazardous/medical waste with an approved hauler at its own
cost.

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          7.3  Landlord shall provide the following during the term of this
Lease:

               (a)  Continually cooperate with all utility companies providing
water, gas and electrical service to the point where they enter the Leased
Premises for Tenant's permitted uses;
               (b)  Extermination and pest control when necessary;
               (c)  24-hour access to the Leased Premises;
               (d)  Maintaining the fire sprinkler system; and
               (e)  Maintenance of the common areas of the Office Park, in a
manner similar to other office parks in the area, with the cost to be passed on
to Tenant as set forth in Paragraph 8.

          7.4  Landlord does not warrant that any services Landlord or any
public utilities supply will not be interrupted. Services may be interrupted
because of accidents, repairs, alterations, improvements or any other reason
beyond the reasonable control of Landlord. Notwithstanding the foregoing, if any
essential services (such as access, electricity or water) supplied to the Leased
Premises are interrupted, or if Landlord fails to make any repairs or
replacements it is required under this Lease to make, and that are necessary to
enable Tenant and its employees, invitees and agents to use the Leased Premises
without material interference, then Tenant shall be entitled to an abatement of
rent and additional rent, unless the problem was caused by Tenant. The abatement
shall begin on the 7th consecutive business day of the interruption or
interference, or when Tenant stops using the Leased Premises because of the
interruption or interference, whichever is later. The abatement shall end when
the services are restored or the repairs or replacements are made or installed.
Tenant shall have the option to cancel this Lease without penalty if the
interruption or failure to repair or replace unreasonably interferes with
Tenant's us or access to the Leased Premises for at least 30 consecutive

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Lease Version Date:  5-31-01

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<PAGE>

days, and Landlord is not exercising its best efforts to restore the services or
make the repair or replacement.

     8.   COMMON AREA EXPENSES, TAXES AND INSURANCE
          -----------------------------------------

          8.1  The Tenant shall pay to the Landlord, monthly, as Additional Rent
the cost of the following items all of which shall be known as Common Area
Expenses:

          (a)  The costs incurred by the Landlord for the operation, maintenance
or repair of the following items in the Office Park, which costs shall be fixed
at $1.75/square foot for the year 2001 and shall increase by 3% each January 1st
commencing on January 1, 2002:

               (1)  lawns and landscaping;

               (2)  water and standby sprinkler charges;

               (3)  exterior lighting;

               (4)  exterior sewer lines;

               (5)  exterior utility lines;

               (6)  repair and maintenance of any signs serving the Office Park;

               (7)  snow removal;

               (8)  normal garbage disposal and recycling;

               (9)  general ground maintenance;

               (10) parking lot, driveways and walkways;

               (11) maintenance contracts for the roof;

               (12) pest control;

               (13) central station monitoring for fire sprinkler system; and

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Lease Version Date:  5-31-01

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               (14) other ordinary maintenance expenses normally incurred by
                    Landlord relating to the Building and common areas of the
                    Office Park;

          The $1.75/square foot, as increased annually, shall include the cost
of the annual insurance premiums charged to the Landlord for insurance coverage
which insure the buildings in the Office Park. The insurance shall be for the
full replacement value of all insurable improvements with any customary
extensions of coverage including, but not limited to, vandalism, malicious
mischief, sprinkler damage and comprehensive liability, and insurance for one
year's rent. The Landlord shall maintain said insurance in effect at all times
hereunder. Any increase in the insurance premiums due to a change in rating of
the Building which is solely attributable to Tenant's use, or due to special
Tenant equipment, shall be paid entirely by the Tenant. Tenant expressly
acknowledges that Landlord shall not maintain insurance on Tenant's furniture,
fixtures, machinery, inventory, equipment or other personal property. Tenant
shall at all times, at its own cost and expense, carry sufficient "All Risk"
property insurance on a replacement cost basis to avoid any coinsurance
penalties in applicable policies on all of Tenant's furniture, furnishings,
fixtures, machinery, equipment and installations as well as on any alterations
or improvements made to the Leased Premises by Tenant at its own cost and
expense subsequent to the Commencement Date. Such coverage is to include
property undergoing additions and alterations, and shall cover the value of
equipment and supplies awaiting installations. On an annual basis, Tenant shall
furnish Landlord with certificates of the existence of such insurance; and

          (b) Tenant's Proportionate Share of the real estate and personal
property taxes assessed against the Office Park for land, building and
improvements, along with any levy for the installation of local improvements
affecting the Office Park assessed by any governmental body

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Lease Version Date:  5-31-01

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<PAGE>

having jurisdiction thereof, which taxes and levies are estimated to be
$1.24/square foot for the first year, provided, however, that Tenant shall be
entitled to Tenant's Proportionate Share of any refund obtained by Landlord with
respect to any taxes. The real estate tax obligation of the Tenant shall include
any tax or imposition for parking lot usage which may be levied by any
governmental body having jurisdiction thereof. In addition to its Proportionate
Share of the above items, Tenant shall pay directly all real estate taxes
assessed by the municipality on its Tenant Improvements. Anything in this
Section 8.1(b) or elsewhere in this Lease to the contrary notwithstanding,
Tenant shall not be obligated to pay any part of (a) any taxes on the income of
the Landlord or the holder of an underlying mortgage and any taxes on the income
of the lessor under any underlying lease, (b) any corporation, unincorporated
business or franchise taxes, (c) any estate gift, succession or inheritance
taxes, (d) any capital gains, mortgage recording or transfer taxes, (e) any
taxes or assessments attributable to any sign attached to, or located on, the
Building or the land or (f) any similar taxes imposed on the Landlord, the
holder of any underlying mortgage or the lessor under any underlying lease; and

          (c)  A management fee of 3% of the Tenant's Base Rent.

          (d)  The following items shall be excluded from Common Area Expenses:

               (1)  Cost of decorating or redecorating other tenant's space, or
                    special cleaning or other services for other tenants;
               (2)  Wages, salaries, fees and fringe benefits paid to
                    administrative or executive personnel or officers or
                    partners of Landlord, unless employed at competitive rates
                    as independent contractors at the Building or Office Park;
               (3)  All costs relating to activities for the solicitation,
                    negotiation, execution and enforcement of leases of space in
                    the Office Park;
               (4)  Cost of any repair or other work made by Landlord because of
                    the total or partial destruction of the Building or the
                    condemnation of a portion of the Building;

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               (5)  Any double charge for an insurance premium for which
                    Landlord is to be reimbursed by Tenant, pursuant to this
                    Lease, or by any other tenant of the Building;
               (6)  Depreciation, amortization, interest or rents paid or
                    incurred by Landlord;
               (7)  Any double charge for real estate taxes for which Landlord
                    is to be reimbursed by Tenant, pursuant to this Lease, or by
                    any other tenant of the Building;
               (8)  Collection costs for bad debt expenses not related to
                    Tenant;
               (9)  Cost of tenant improvements;
               (10) Legal, accounting, bank or other fees incurred in connection
                    with any equity or debt financing or sale of the Building or
                    Office Park;
               (11) Cost of specialized services provided to other tenants, but
                    not provided to tenants generally;
               (12) Capital expenditures as defined according to GAAP, or the
                    cost of rentals and related expenses incurred in leasing
                    items ordinarily considered to be of a capital nature;
               (13) Cost to comply with ADA related to the interior of the
                    individual buildings, but not exterior doors or the costs of
                    improvements required by ADA to the Office Park amortized
                    over their useful life;
               (14) Fines or costs to cure violations of law or ordinances in
                    the common areas; (15) Electric for non-public areas.

          8.2 Tenant's Share of Common Area Expenses for any calendar year, part
of which falls within the term of this Lease and part of which does not, shall
be appropriately prorated.

          8.3 If at any time during the term of this lease the method or scope
of taxation prevailing at the commencement of the lease term shall be altered,
Tenant's Proportionate Share of such substituted tax or imposition shall be
payable and discharged by the Tenant in the manner required pursuant to the law
which shall authorize such change.

          8.4 The Tenant covenants and agrees that it will, at its sole cost and
expense, carry liability insurance covering the Leased Premises in the minimum
amount of $1,000,000.00 per accident for 1 person, $3,000,000.00 per accident
for 2 or more persons, and a minimum amount of $300,000.00 for property damage.
The Tenant shall add the Landlord as an additional insured on such policy and
will furnish Landlord with a certificate of said liability insurance prior to
the

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

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<PAGE>

 Commencement Date and annually thereafter. The certificate shall contain a
clause that the policy will not be canceled except on 10 days written notice to
the Landlord.

          8.5 The parties covenant and agree that the insurance policies
required to be furnished in accordance with the terms and conditions of this
Lease, or in connection with insurance policies which they obtain insuring such
insurable interest as Landlord or Tenant may have in its own properties, whether
personal or real, shall expressly waive any right of subrogation on the part of
the insurer against the Landlord or Tenant. Landlord and Tenant each waives all
right of recovery against the other, its agents or employees for any loss,
damage or injury of any nature whatsoever to property or person for which the
waiving party is required by this lease to carry insurance.

     9.   SIGNS

          At its sole expense the Tenant shall have the right to install on the
windows and doors at the Leased Premises, only such signs as are required by
Tenant for the purpose of identifying the Tenant, which signs shall be
compatible with the design plan for the Office park. The signs shall comply with
the rules and regulations of the applicable governmental boards and bureaus
having jurisdiction thereof.

     10.  ASSIGNMENT AND SUBLETTING

          10.1 The Tenant may not assign or sublet the Leased Premises without
Landlord's consent, which shall not be unreasonably conditioned, delayed or
withheld. Tenant shall advise the Landlord in writing, by certified mail, return
receipt requested of its desire to assign or sublease and Landlord shall have 10
days from receipt of such notice to notify Tenant whether it rejects or consents
to the assignment or sublease. Landlord shall also have the option to elect to
re-capture the Leased Premises and terminate the Lease. If Landlord elects to
recapture the Leased Premises,

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Tenant shall surrender the Leased Premises no later than 90 days after
Landlord's written notice of its election to recapture.

          10.2 The Landlord's consent shall not be required and the terms and
conditions of Paragraph 10.1 shall not apply as to Landlord's right to recapture
if the Tenant assigns or subleases the Leased Premises to a parent, subsidiary,
affiliate or a company into which Tenant is merged or with which Tenant is
consolidated, or to the purchaser of all or substantially all of the stock or
assets of Tenant.

          10.3 In connection with any permitted assignment or subletting, (i)
the Tenant shall pay monthly to the Landlord 50% of any increment in rent
received by Tenant per square foot over the rent then in effect during the year
of the assignment or subletting, which payment shall be made monthly together
with the required rent hereunder; and (ii) if Tenant receives any consideration
or value for such assignment or subletting, Landlord shall be paid 50% of any
such consideration or value within 10 days after receipt of the same by Tenant.
As a condition hereunder, Tenant warrants and represents to Landlord that it
will furnish to Landlord a copy of all pertinent documents with respect to any
such assignment or subletting so as to establish Tenant's obligation to Landlord
hereunder.

          10.4 In the event of any assignment or subletting permitted by the
Landlord, the Tenant shall remain and be directly and primarily responsible for
payment and performance of the within Lease obligations, and the Landlord
reserves the right, at all times, to require and demand that the Tenant pay and
perform the terms and conditions of this Lease. In the case of a complete
recapture, Tenant shall be released from all further liability with respect to
the recaptured space. No such assignment or subletting shall be made to any
Tenant who shall occupy the Leased Premises for

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Lease Version Date:  5-31-01

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<PAGE>

any use other than that which is permitted to the Tenant, or for any use which
may be deemed inappropriate for the Building or extra hazardous, or which would
in any way violate applicable laws, ordinances or rules and regulations of
governmental boards and bodies having jurisdiction.

     11.  FIRE AND CASUALTY

          11.1 In case of any damage to or destruction of any portion of the
building of which the Leased Premises is a part by fire or other casualty
occurring during the term of this lease (or previous thereto), which shall
render at least 1/3 of the floor area of the Leased Premises or the building
untenantable or unfit for occupancy, which damage cannot be repaired within 180
days from the happening of such casualty, using reasonable diligence ("Total
Destruction") then the term hereby created shall, at the option of the Landlord
or Tenant, upon written notice to the other within 15 days of such fire or
casualty, cease and become null and void from the date of such Total
Destruction. In such event the Tenant shall immediately surrender the Leased
Premises to the Landlord and this Lease shall terminate. The Tenant shall only
pay rent to the time of such Total Destruction. However, in the event of Total
Destruction if the Landlord or Tenant shall elect not to cancel this lease
within the 15 day period the Landlord shall repair and restore the same to
substantially the same condition as it was prior to the damage or destruction,
with reasonable speed and dispatch. The rent shall not be accrued after said
damage or while the repairs and restorations are being made, but shall
recommence immediately after the premises are restored as evidenced by the
issuance of a CO/CA by municipal authorities. In any case where Landlord must
restore, consideration shall be given for delays under the Force Majeure
paragraph in this Lease. Whether or not this lease has been terminated as a
result of a casualty, in every instance, all insurance

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Lease Version Date:  5-31-01

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<PAGE>

proceeds payable as a result of damage or destruction to the Building shall be
paid to Landlord as its sole and exclusive property.

          11.2 In the event of any other casualty which shall not be tantamount
to Total Destruction the Landlord shall repair and restore the Building and the
Leased Premises to substantially the same condition as they were prior to the
damage or destruction, with reasonable speed and dispatch. The rent shall abate
or shall be equitably apportioned as to any portion of the Leased Premises which
shall be unfit for occupancy by the Tenant, or which cannot be used by the
Tenant to conduct its business. The rent shall recommence immediately upon
restoration of the Leased Premises as evidenced by the issuance of a CO/CA by
municipal authorities.

          11.3 In the event of any casualty caused by an event which is not
covered by Landlord's insurance policy; the Landlord may elect to treat the
casualty as though it had insurance or it may terminate the lease. If it treats
the casualty as though it had insurance then the provisions of this paragraph
shall apply. The Landlord shall serve a written notice upon the Tenant within 15
days of the casualty specifying the election which it chooses to make.

          11.4 In the event the Landlord rebuilds, the Tenant agrees, at its
cost and expense, to forthwith remove any and all of its equipment, fixtures,
stock and personal property in order to permit Landlord to expedite the
construction. The Tenant shall assume at its sole risk the responsibility for
damage to or security of such fixtures and equipment in the event that any
portion of the building area has been damaged and is not secure.

     12.  COMPLIANCE WITH LAWS, RULES AND REGULATIONS
          -------------------------------------------

          12.1 (a) The Tenant agrees that upon acceptance and occupancy of the
Leased Premises, it will, at its own cost and expense, comply with all statutes,
ordinances, rules, orders,

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regulations and requirements of the Federal, State and Municipal governments
("Applicable Laws") relating to the manner in which Tenant uses the Leased
Premises. The Tenant also agrees that it will not commit any nuisance, and will
dispose of all garbage and waste in connection with its operations so as to
avoid unreasonable emissions of dirt, fumes, odors or debris. Landlord warrants
that on the date this Lease commences, the Leased Premises and the Building of
which it is a part will comply with all Applicable Laws. Notwithstanding
anything to the contrary, in no case shall Tenant be required to comply with
Applicable Laws with regard to any structural component or Building system that
is Landlord's responsibility pursuant to this Lease. Landlord will comply with
all Applicable Laws with regard to the Building shell, core area and Building
systems that are not the responsibility of the Tenant. Landlord shall indemnify,
defend and save the Tenant harmless against any claim, damage, liability, cost,
penalty or fine which the Tenant may suffer as a result of air, ground or water
pollution which requires remediation under any environmental law and exists at
the date of Substantial Completion.

               (b) The Tenant agrees, at its own cost and expense, to comply
with such regulations or requests as may be reasonably required by the fire or
liability insurance carriers providing insurance for the Leased Premises, and
the Board of Fire Underwriters, in connection with Tenant's use and occupancy
of the Leased Premises.

          12.2 In case the Tenant shall fail to comply with all material
provisions of the aforesaid statutes, ordinances, rules, orders, regulations and
requirements then the Landlord may, after 30 days' notice (except for emergency
repairs, which may be made immediately), and provided that Tenant has failed to
take such reasonable action to investigate or remedy the reason for
noncompliance, enter the Leased Premises and take any reasonable actions to
comply with them,

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<PAGE>

at the cost and expense of the Tenant. The cost thereof shall be added to the
next month's rent and shall be due and payable as such, or the Landlord may
deduct the same from the balance of any sum remaining in the Landlord's hands.
This provision is in addition to the right of the Landlord to terminate this
Lease by reason of any default on the part of the Tenant. However, in the event
that all necessary repairs are made by Tenant, or if Tenant proceeds with
reasonable diligence to investigate and repair such noncompliance, the initial
failure to comply with the aforesaid laws and regulations shall not constitute
an event of default.

          12.3 Tenant expressly covenants and agrees to indemnify, defend and
save the Landlord harmless against any claim, damage, liability, cost,
penalties, or fines which the Landlord may suffer as a result of air, ground or
water pollution which requires remediation under any environmental law and is
caused by the Tenant in its use of the Leased Premises. The Tenant covenants and
agrees to notify the Landlord immediately of any claim or notice served upon it
with respect to any claim that the Tenant is causing air, ground or water
pollution; and the Tenant shall take immediate steps to halt, remedy or cure any
pollution of air, ground or water caused by the Tenant by its use of the Leased
Premises.

          12.4 Tenant expressly covenants and agrees to fully comply with the
provisions of the New Jersey Industrial Site Recovery Act (N.J.S.A. 13:1K-6, et
seq.) "ISRA", and its regulations to the extent applicable, prior to the
termination of the Lease or at any time that any action of the Tenant triggers
the applicability of ISRA. In particular, the Tenant agrees that it shall comply
with the provisions of ISRA in the event of any "closing, terminating or
transferring" of Tenant's operations, as defined by and in accordance with the
regulations. In the event ISRA is applicable and evidence of Tenant's compliance
is not delivered to the Landlord prior to surrender of the Leased

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Lease Version Date:  5-31-01

                                       22
<PAGE>

Premises by the Tenant to the Landlord, it is understood and agreed that the
Tenant shall be liable to pay to the Landlord an amount equal to two times the
Original Base Rent then in effect, together with all applicable Additional Rent
from the date of such surrender until such time as evidence of compliance with
ISRA has been delivered to the Landlord, and together with any costs and
expenses incurred by Landlord in enforcing Tenant's obligations under this
paragraph. Evidence of compliance, as used herein, shall mean a "letter of
non-applicability" issued by the New Jersey Department of Environmental
Protection ("NJDEP"), an approved "negative declaration" or a "remediation
action plan" which has been fully implemented and approved by NJDEP or other
equivalent document as may then be prescribed by applicable regulations.
Evidence of compliance shall be delivered to the Landlord, together with copies
of all submissions made to the NJDEP, including all environmental reports, test
results and other supporting documentation. In addition to the above, Tenant
agrees that it shall reasonably cooperate with Landlord in the event ISRA is
applicable to any portion of the Property of which the Leased Premises are a
part. In such case, Tenant agrees that it shall fully cooperate with Landlord in
connection with any information or documentation which may be requested by the
NJDEP, provided Landlord pays all of Tenant's reasonable costs thereof. In the
event that any remediation of the Property is required in connection with the
conduct by Tenant of its business at the Leased Premises, Tenant expressly
covenants and agrees that it shall be responsible for only that portion of the
remediation which is attributable to the Tenant's operation. It is understood
and agreed that Tenant shall not be responsible for any ISRA related expenses
applicable to any portion of the Office Park not under the operation and control
of the Tenant. Tenant hereby represents and warrants that its Standard
Industrial Classification No. is 8731, and that Tenant shall not generate,
manufacture, refine, transport, treat, store, handle or

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Lease Version Date:  5-31-01

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<PAGE>

dispose of "hazardous substances" as the same are defined under ISRA and the
regulations promulgated pursuant thereto, except in strict compliance with all
governmental rules, regulations and procedures. Tenant hereby agrees that it
shall promptly inform Landlord of any change in its SIC number and obtain
Landlord's consent for any change in the nature of the business to be conducted
in the Leased Premises. The within covenants shall survive the expiration or
earlier termination of the lease term.

     12.5 Landlord represents that, to the best of its knowledge, the Leased
Premises, Building and Office Park are currently in compliance with all
environmental laws.

     13.  INSPECTION BY LANDLORD
          ----------------------

          The Tenant agrees that the Landlord shall have the right to enter into
the Leased Premises at all reasonable hours for the purpose of examining the
same upon reasonable advance notice of not less than 24 hours (except in the
event of emergency), or to make such repairs as are necessary. Any repair shall
not unduly interfere with Tenant's use of the Leased Premises. Unless Tenant
permits otherwise, Landlord shall only enter the Leased Premises: (a) when
accompanied by a duly-authorized representative of Tenant; (b) when wearing any
and all protective clothing and equipment that Tenant may require in order to
alleviate disturbance of Tenant's operations in non-office portions; and (c) at
hours and in a manner which will not disturb or unduly interfere with Tenant's
operations.

     14.  DEFAULT BY TENANT
          -----------------

          14.1 Each of the following shall be deemed a default by Tenant and a
breach of this Lease:

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       24
<PAGE>

               (a)  (1)  filing of a petition by the Tenant for adjudication as
                         a bankrupt, or for reorganization, or for an
                         arrangement under any federal or state statute, except
                         in a Chapter 11 Bankruptcy where the rent and
                         Additional Rent stipulated herein is being paid and the
                         terms of the lease are being complied with;

                    (2)  dissolution or liquidation of the Tenant;

                    (3)  appointment of a permanent receiver or a permanent
                         trustee of all or substantially all of the property of
                         the Tenant, if such appointment shall not be vacated or
                         stayed within 90 days, provided the rent and Additional
                         Rent stipulated herein is being paid and the terms of
                         the lease are being complied with, during said 90 day
                         period;

                    (4)  taking possession of the property of the Tenant by a
                         governmental officer or agency pursuant to statutory
                         authority for dissolution, rehabilitation,
                         reorganization or liquidation of the Tenant if such
                         taking of possession shall not be vacated or stayed
                         within 90 days, provided the rent and Additional Rent
                         stipulated herein is being paid and the terms of the
                         lease are being complied with, during said 90 day
                         period;

                    (5)  making by the Tenant of an assignment for the benefit
                         of creditors;

                    (6)  abandonment, desertion or vacation of the Leased
                         Premises by the Tenant;

               (b)  Default in the payment of the rent or Additional Rent herein
reserved or any part thereof, when due, which continues for 10 days after notice
from Landlord of such default. However, if Tenant is more than 10 days late
twice in any 12 month period, then the 10 day grace period is reduced to 5 days
upon notice to Tenant; and written notice shall no longer be required from
Landlord during the term of the Lease.

               (c) A default in the performance of any other covenant or
condition which this Lease requires the Tenant to perform, for a period of 30
days after notice. However, no default on

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       25
<PAGE>

the part of Tenant shall be deemed to exist if it diligently commences efforts
to rectify same withing such 30 day period, and Landlord is indemnified against
loss or liability arising from the default.

          14.2 In the event of any default set forth above, and lapse of
applicable grace period, Landlord may serve written notice upon the Tenant
electing to terminate this lease upon a specified date not less than 10 days
after the date of serving such notice and this Lease shall then expire on the
date so specified as if that date had been originally fixed as the expiration
date of the term herein granted. However, an event of default shall be deemed
waived if such default is cured before the date specified for termination in the
notice of termination served on the Tenant.

          14.3 In case this Lease shall be terminated due to Tenant's default as
set forth above, Landlord or its agents may, immediately or any time thereafter,
re-enter and resume possession of the Leased Premises or such part thereof, and
remove all persons and property therefrom, either by summary proceedings or a
suitable action or proceeding at law, without being liable for any damages
therefor. No re-entry by Landlord shall be deemed an acceptance of a surrender
of this lease. However, if the Tenant is in default and moves out, or is
dispossessed, and fails to remove any property, machinery, equipment and
fixtures or other property within 10 days after such default, dispossession or
removal, then and in that event, the said property, machinery, equipment and
fixtures or other property shall at the option of the Landlord, be deemed to be
abandoned, or the Landlord may remove such property and charge the reasonable
cost and expense of removal and storage to the Tenant. The Tenant shall be
liable for any damage which it causes in the removal of said property from the
Leased Premises.

          14.4 In case this Lease shall be terminated, due to Tenant's default
as set forth above Landlord may relet the whole or any portion of the Leased
Premises for any period equal to or

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       26
<PAGE>

greater or less than the remainder of the then current term, for any sum which
it may deem reasonable, to any tenant which it may deem reasonably suitable and
satisfactory, and for any use and purpose which it may deem appropriate. In
connection with any such lease Landlord may make such changes in the character
of the improvements on the Leased Premises as Landlord may determine to be
appropriate or helpful in effecting such lease and may grant concessions or free
rent. Landlord shall make reasonable efforts to relet the Leased Premises.
Landlord shall not in any event be required to pay Tenant any sums received by
Landlord on such reletting of the Leased Premises, but this shall not effect
Landlord's statutory obligation to mitigate its damages. Amounts received shall
be applied against amounts due from Tenant.

          14.5 In the event this Lease is terminated due to Tenant's default as
set forth above, and whether or not the Leased Premises be relet, Landlord shall
be entitled to recover from the Tenant all rent due and all expenses, including
reasonable counsel fees, incurred by Landlord in recovering possession of the
Leased Premises, and all reasonable costs and charges for the care of the Leased
Premises while vacant, which damages shall be due at such time as they are
incurred by Landlord; and all other damages set forth in this Paragraph 14 and
in Paragraph 15. Without any previous notice or demand, separate actions may be
maintained by Landlord against Tenant from time to time to recover any damages
which have become due and payable to the Landlord without waiting until the end
of the term.

     150  LIABILITY OF TENANT FOR DEFICIENCY
          ----------------------------------

          In the event that the relation of the Landlord and Tenant terminates
     by reason of

          (a) a default by the Tenant and the re-entry of the Landlord as
permitted herein;

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       27
<PAGE>

          (b) by the ejectment of the Tenant by summary proceedings or other
judicial proceedings;

          (c) after the abandonment of the Leased Premises by the Tenant, it is
hereby agreed that the Tenant shall remain liable to pay in monthly payments the
rent and any other charges which shall accrue. The Tenant expressly agrees to
pay as damages for such breach of this Lease the difference between the rent
reserved and the rent received, if any, by the Landlord, during the remainder of
the unexpired term.

     160  NOTICES
          -------

          All notices required by this Lease shall be given either by certified
mail, return receipt requested, or overnight courier, or personal delivery with
receipt, at the address set forth on the first page of this lease, and/or such
other place as the parties may designate in writing. Any notices hand delivered
or sent by nationally recognized overnight courier shall be deemed delivered
when received. All notices sent by mail shall be deemed given 3 days after
deposit in the mail. Upon Tenant's occupancy, Tenant's address for notices shall
be the Leased Premises.

     170  NON-WAIVER BY LANDLORD
          ----------------------

          The failure of either party to insist upon the strict performance of
any of the terms of this Lease, or to exercise any option contained herein,
shall not be construed as a waiver of any such term. Acceptance of performance
of anything required by this Lease to be performed, with the knowledge of the
breach of any term of this Lease, shall not be deemed a waiver of such breach,
nor shall acceptance of rent by Landlord in a lesser amount than is due
(regardless of any endorsement on any check, or any statement in any letter
accompanying any payment of rent) be construed either as an accord and
satisfaction or in any manner other than as payment on account of the earliest
rent

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       28
<PAGE>

then unpaid by Tenant. No waiver of any term of this Lease shall be deemed to
have been made unless expressed in writing and signed by the benefitted party.

     180  RIGHT OF TENANT TO MAKE ALTERATIONS AND IMPROVEMENTS
          ----------------------------------------------------

          The Tenant may not make alterations, additions or improvements to the
Leased Premises, or change the door locks or window coverings, or in any way
alter access to the Leased Premises without the consent of the Landlord, which
consent Landlord is not required to give. Landlord agrees to review any
alterations, additions, or improvements proposed by Tenant within 15 days of
receipt of plans and specifications, and advise Tenant of its decision. If
Landlord does not respond within the said 15 days, then consent is deemed given.
If consent is given Landlord will advise, at that time, whether the alterations,
additions or improvements must be removed by Tenant at the expiration or earlier
termination of the Lease. Any approval given is not intended to subject the
Landlord's property to liability under any lien law. Tenant shall be responsible
for obtaining at its own cost and expense all licenses, permits and approvals
that may be required by any governmental entity having jurisdiction over the
approved alterations, additions and/or improvements. Tenant shall furnish to
Landlord as-built drawings of any alterations, additions or improvements which
are made.

     190  NON-LIABILITY OF LANDLORD
          -------------------------

          Tenant agrees to assume all risk of damage to its property, equipment
and fixtures occurring in or about the Leased Premises, whatever the cause of
such damage or casualty. Landlord shall not be liable for any damage or injury
to property or person caused by or resulting from steam, electricity, gas,
water, rain, ice or snow, or any leak or flow from or into any part of the
building, or from any damage or injury resulting or arising from any other cause
or happening whatsoever, unless

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       29
<PAGE>

arising from gross negligence or willful misconduct of Landlord or its agents,
contractors or employees.

     200  RESERVATION OF EASEMENT
          -----------------------

          Landlord reserves the right, easement and privilege to enter on the
Leased Premises in order to install, at its own cost and expense, any storm
drains and sewers and/or utility lines and services in connection therewith as
may be required by the Landlord. It is understood and agreed that if such work
as may be required by Landlord requires any interior installation, or displaces
any exterior paving or landscaping, the Landlord shall at its own cost and
expense, restore such items, to substantially the same condition as they were
before such work. The Landlord covenants that the foregoing work shall not
unreasonably interfere with the normal operation of Tenant's business.

     210  STATEMENT OF ACCEPTANCE
          -----------------------

          Upon the delivery of the Leased Premises to the Tenant the Tenant
covenants and agrees that it will furnish to Landlord a statement which shall
set forth the Date of Commencement and the Date of Expiration of the lease term.

     220  FORCE MAJEURE
          -------------

          Except for the obligation of the Tenant to pay rent and other charges,
the period of time during which the Landlord or Tenant is prevented from
performing any act required to be performed under this Lease by reason of fire,
catastrophe, strikes, lockouts, civil commotion, weather conditions, acts of
God, government prohibitions or preemptions or embargoes, inability to obtain
material or labor by reason of governmental regulations, the act or default of
the other party, or other events beyond the reasonable control of Landlord or
Tenant, as the case may be, shall be added to the time for performance of such
act.

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       30
<PAGE>

     230  STATEMENTS BY LANDLORD AND TENANT
          ---------------------------------

          Landlord and Tenant agree at any time and from time to time upon not
less than 10 days' prior notice from the other to execute, acknowledge and
deliver to the party requesting same, a statement in writing, certifying that
this lease is unmodified and in full force and effect (or if there have been
modifications, that the same is in full force and effect as modified and stating
the modifications), that it is not in default (or if claimed to be in default,
stating the amount and nature of the default) and specifying the dates to which
the basic rent and other charges have been paid in advance.

     240  CONDEMNATION
          ------------

          24.1 If due to condemnation, (i) more than 15% of the Leased Premises
is taken or rendered untenantable, or (ii) more than 25% of the ground is taken
(including parking areas, but excluding front, side and rear set back areas)
and, in Landlord's or Tenant's opinion, said taking unreasonably or unduly
interferes with the use of the Leased Premises, the lease term created shall
terminate from the date when the authority exercising the power of eminent
domain takes or interferes with the use of the Property. The Tenant shall be
responsible for the payment of rent until the time of surrender. In any event,
no part of the Landlord's condemnation award shall be claimed by the Tenant.
Without diminishing Landlord's award, the Tenant shall have the right to make a
claim against the condemning authority for such independent claim which it may
have.

          24.2 In the event of any partial taking which would not be cause for
termination of the Lease, or in the event of any taking in excess of the
percentages provided above and Tenant retains the balance of the Leased Premises
remaining after such taking, then the rent shall abate in an amount to be
mutually agreed upon between the Landlord and Tenant based on the relationship
that

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       31
<PAGE>

the character of the property prior to the taking bears to the property which
shall remain after the condemnation. The Landlord shall, to the extent permitted
by applicable law and as the same may be practicable promptly make such repairs
and alterations in order to restore the Building and/or improvements to a usable
condition to the extent of any condemnation award received by Landlord.

     250  LANDLORD'S REMEDIES
          -------------------

          25.1 The rights and remedies given to the Landlord in this lease are
distinct, separate and cumulative remedies, and no one of them, whether or not
exercised by the Landlord, shall be deemed to be in exclusion of any of the
others.

          25.2 In addition to any other legal remedies for violation or breach
of this lease by the Tenant or by anyone holding or claiming under the Tenant
such violation or breach shall be restrainable by injunction at the suit of the
Landlord.

          25.3 No receipt of money by the Landlord from any receiver, trustee or
custodian or debtors in possession shall reinstate, or extend the term of this
lease or affect any notice theretofore given to the Tenant, or to any such
receiver, trustee, custodian or debtor in possession, or operate as a waiver or
estoppel of the right of the Landlord to recover possession of the Leased
Premises for any of the causes therein enumerated by any lawful remedy; and the
failure of the Landlord to enforce any covenant or condition by reason of its
breach by the Tenant shall not be deemed to void or affect the right of the
Landlord to enforce the same covenant or condition on the occasion of any
subsequent default or breach.

     260  QUIET ENJOYMENT
          ---------------

          The Landlord covenants that the Tenant, on paying the rental and
performing the covenants and conditions contained in this Lease, subject to
applicable notice and grace periods, may

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       32
<PAGE>

peaceably and quietly have, hold and enjoy the Leased Premises, in the manner of
a multi-tenanted building, for the Lease term.

     270  SURRENDER OF PREMISES
          ---------------------

          On the last day, or earlier permitted termination of the Lease term,
Tenant shall quit and surrender the Leased Premises in good and orderly
condition and repair (reasonable wear and tear, and damage by fire or other
casualty excepted) and shall deliver and surrender the Leased Premises to the
Landlord peaceably, together with all Tenant Improvements. The Landlord reserves
the right, however, to require the Tenant at its cost and expense to remove any
alterations, additions or improvements installed by the Tenant, and restore the
Leased Premises to its original state, normal wear and tear excepted, unless the
Landlord has previously advised Tenant that same may remain. Prior to the
expiration of the Lease term the Tenant shall remove all of its tangible
property, fixtures, equipment and trade fixtures from the Leased Premises. All
property not removed by Tenant shall be deemed abandoned by Tenant, and Landlord
reserves the right to charge the reasonable cost of such removal to the Tenant.
If the Leased Premises are not surrendered at the end of the Lease term, the
Tenant shall be liable for double rent under NJSA 2A:42-6, on a monthly basis
pro-rated until date or surrender, and Tenant shall indemnify Landlord against
loss or liability resulting from delay by Tenant in surrendering the Leased
Premises, including, without limitation any claims made by any succeeding tenant
founded on the delay, and any loss of income suffered by Landlord. These
covenants shall survive the termination of the Lease.

     280  INDEMNITY
          ---------

          (a) Anything in this Lease to the contrary notwithstanding, and
without limiting the Tenant's obligation to provide insurance hereunder the
Tenant covenants and agrees that it will

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       33
<PAGE>

indemnify, defend and save harmless the Landlord against and from all
liabilities, obligations, damages, penalties, claims, costs, charges and
expenses, including without limitation reasonable attorneys' fees, which may be
imposed upon or incurred by Landlord by reason of any of the following occurring
during the term of this Lease:

               (1) Any matter, cause or thing arising out of Tenant's use,
occupancy, control or management of the Leased Premises and any part thereof
unless arising from the negligence or willful misconduct of Landlord, its
agents, contractors, employees or invitees.

               (2) Any negligence on the part of the Tenant or any of its
agents, employees, licensees or invitees, arising in or about the Leased
Premises.

               (3) Any failure on the part of Tenant to perform or comply with
any of its covenants, agreements, terms or conditions contained in this Lease.

          Landlord shall promptly notify Tenant of any such claim asserted
against it and shall promptly send to Tenant copies of all papers or legal
process served upon it in connection with any action or proceeding brought
against Landlord.

          (b) Landlord covenants and agrees that it will indemnify, defend and
save harmless the Tenant against and from all liabilities, obligations, damages,
penalties, claims, costs, charges and expenses, including without limitation
reasonable attorney's fees, related to any matter, cause or thing arising out of
Landlord's ownership, control or management of the Office Park, unless arising
out of the negligence or willful misconduct of Tenant, its agents, employees or
invitees.

     290  BIND AND CONSTRUE CLAUSE
          ------------------------

          The terms, covenants and conditions of this Lease shall be binding
upon, and inure to the benefit of, each of the parties hereto and their
respective heirs, successors and assigns. If any

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       34
<PAGE>

one of the provisions of this Lease shall be held to be invalid by a court of
competent jurisdiction, such adjudication shall not affect the validity or
enforceability of the remaining portions of this Lease. The parties each
acknowledge to the other that this Lease has been drafted by both parties, after
consultation with their attorneys, and in the event of any dispute, the
provisions are not to be interpreted against either party as the drafter of the
Lease.

     300  INCLUSIONS
          ----------

          The neuter gender when used herein, shall include all persons and
corporations, and words used in the singular shall include words in the plural
where the text of the instrument so requires.

     310  DEFINITION OF TERM "LANDLORD"
          -----------------------------

          When the term "Landlord" is used in this Lease it shall be construed
to mean and include only the entity which is the owner of title to the building.
Upon the transfer by the Landlord of the title, the Landlord shall advise the
Tenant in writing by certified mail, return receipt requested, of the name of
the Landlord's transferee. In such event, the Landlord shall be automatically
freed and relieved from and after the date of such transfer of title of all
personal liability with respect to the performance of any of the covenants and
obligations on the part of the Landlord herein contained to be performed,
provided any such transfer and conveyance by the Landlord is expressly subject
to the assumption by the transferee of the obligations of the Landlord
hereunder.

     320  COVENANTS OF FURTHER ASSURANCES
          -------------------------------

          If, in connection with obtaining financing for the improvements on the
Leased Premises, the mortgage lender shall request reasonable modifications in
this lease as a condition to such financing, Tenant will not unreasonably
withhold, delay or refuse its consent thereto, provided

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       35
<PAGE>

that such modifications do not in Tenant's reasonable judgment increase the
obligations or decrease the rights of Tenant hereunder or materially adversely
affect the leasehold interest hereby created or Tenant's use and enjoyment of
the Leased Premises.

     330  COVENANT AGAINST LIENS
          ----------------------

          Tenant agrees that it shall not encumber, or permit to be encumbered,
the Leased Premises or the fee thereof by any lien, charge or encumbrance, and
Tenant shall have no authority to mortgage or hypothecate this Lease in any way
whatsoever. Any violation of this Paragraph shall be considered a breach of this
Lease.

     340  SUBORDINATION
          -------------

          This Lease shall be subject and subordinate at all times to the lien
of any mortgages or ground leases or other encumbrances now or hereafter placed
on the land and building and Leased Premises without the necessity of any
further instrument or act on the part of Tenant to effectuate such
subordination. However, Tenant agrees to execute such further documents
evidencing the subordination of the Lease to the lien of any mortgage or ground
lease as shall be desired by Landlord within 5 days. Landlord shall use its best
efforts to obtain a Subordination, Non-disturbance and Attornment Agreement from
any current or future mortgagee, which shall provide that so long as no event of
default has occurred and is continuing, Tenant's rights under this Lease shall
not be disturbed.

     350  EXCULPATION OF LANDLORD
          -----------------------

          Neither Landlord nor its principals shall have any personal obligation
for payment of any indebtedness or for the performance of any obligation under
this Lease. The performance of Landlord's obligations expressed herein may be
enforced only against the building and land of which

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       36
<PAGE>

the Leased Premises are a part, and the rents, issues and profits thereof. The
Tenant agrees that no deficiency judgment or other judgment for money damages
shall be entered by it against the Landlord or its principals personally in any
action. This exculpation provision shall not apply to a misappropriation of
Tenant's security deposit.

     360  NET RENT
          --------

          It is the intent of the Landlord and Tenant that this Lease shall
yield, net to Landlord, the rent specified and all Additional Rent and charges
in each month during the term of the Lease, and that all costs, expenses and
obligations of every kind relating to the Leased Premises shall be paid by the
Tenant, unless expressly assumed by the Landlord.

     370  SECURITY
          --------

          Upon execution of this Lease, the Tenant shall deposit with the
Landlord four months rent as security for the full and faithful performance of
its obligations under this Lease. Upon termination of this Lease, and providing
the Tenant is not in default hereunder, beyond the applicable notice and cure
periods, and has performed all of the conditions of this Lease, the Landlord
shall return the security deposit to the Tenant. Tenant covenants and agrees
that it will not assign, pledge, hypothecate, mortgage or otherwise encumber the
security during the term of this Lease. It is expressly understood and agreed
that the Landlord shall not be required to segregate the security.

     380  BROKERAGE
          ---------

          The parties mutually represent to each other that The Staubach Company
is the broker who negotiated and consummated the within transaction, and that
neither party dealt with any other broker in connection with the Lease. In the
event either party violates this representation, it shall

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       37
<PAGE>

indemnify and defend and hold the other party harmless from all claims and
damages. It is agreed that the Landlord shall be responsible, at its sole cost
and expense, to pay the brokerage commission in connection with this Lease.

     390  LATE CHARGES
          ------------

          In addition to any other remedy, a late charge of 1-1/2% per month,
retroactive to the date rent was due, shall be due and payable, without notice
from Landlord, on any portion of rent or other charges not paid within 5 days of
the due date.

     400  PRESS RELEASES
          --------------

          Subject to the prior written approval of Tenant (which shall not be
unreasonably withheld), Landlord shall have the right to announce the execution
of this Lease, the parties hereto, and the real estate brokers involved in such
press releases as landlord shall deem advisable. In addition, Tenant shall
permit landlord to use its name and photographs of the Leased Premises (all
photographs being subject to Tenant's prior consent) in Landlord's marketing
brochures and materials, and Tenant agrees to reasonably cooperate with Landlord
in such regard, but at no cost or expense to Tenant.

     410  WAIVER OF JURY TRIAL
          --------------------

          Landlord and Tenant both irrevocably waive a trial by jury in any
action or proceeding between them or their successors or assigns arising out of
this Lease or any of its provisions, or Tenant's use or occupancy of the Leased
Premises.

     420  LAWS OF NEW JERSEY
          ------------------

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       38
<PAGE>

          Without regard to principles of conflicts of laws, the validity,
interpretation, performance and enforcement of this lease shall be governed by
and construed in accordance with the laws of the State of New Jersey. The sole
and exclusive venue for any dispute between the parties shall be in Middlesex
County, New Jersey.

     430  OPTION TO RENEW
          ---------------

          Provided the Tenant is not in default hereunder beyond the applicable
notice and cure periods, it has the right to renew the lease, for a two 5 year
periods, to commence at the end of the prior term of this Lease. The renewal
shall be upon the same terms and conditions as contained in this Lease, except
as follows:

          (a) The Base Rent during the last year of the prior Lease term shall
be increased by any increase in the Cost of Living index defined as follows:

          At the inception of each renewal term, there shall be compared the
     "All Items" Index Figures for the New York-Northeastern New Jersey average
     of the "Consumer Price Index for All Urban Consumers" (revised CPI-U)
     (1982-1984 equal to 100) published by the Bureau of Labor Statistics of the
     U.S. Department of Labor ("Index") for the first month of the prior term of
     this Lease with the first month of the renewal term. If there is an
     increase in the Index that increase shall be the basis for determining the
     rent increase over the Base Rent, shown in the following example:

          If the Index figure for the first month of the prior term is 100 (the
          denominator) and the Index figure for the first month of the renewal
          term is 115, the increase in the Index figures will produce an
          increase of 15%.

                                 (115-100) = 15%
                                 ---------
                                    100

          However, in no event shall the increase in rent be less than 3% for
each year of the prior Lease term. Since the rent payment for at least the first
month of the renewal term will have

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       39
<PAGE>

been paid prior to the determination of any applicable rent increase in excess
of the prior term's Base Rent, any increase for months already elapsed after
commencement of the renewal term shall be added to the next monthly rent payment
then becoming due and payable.

          (b) In the event that the Index figure is discontinued the parties
shall agree on an equivalent and substituted Cost of Living Index to be applied
in the same manner. In the event the parties cannot mutually agree as to a
substituted Index, then the issue shall be submitted for arbitration to the
American Arbitration Association to take place in South Brunswick or any of its
contiguous municipalities, with the cost thereof divided between the parties.

          (c) The option of the Tenant to renew this Lease is expressly
conditioned upon the Tenant delivering to the Landlord a notice, in writing, by
certified mail, return receipt requested 180 days prior to the date fixed for
termination of the prior Lease term.

          (d) If the base year (1982-84 equal to 100) herein above referred to
with respect to the "Index" shall be changed after the execution of the Lease,
appropriate adjustments based on such new Index shall be made so as to have a
proper application of the Cost of Living formula.

          IN WITNESS WHEREOF, the parties hereto have executed this document on
the date first above written.

                                  Cedar Brook Corporate Center, L.P.
                                  By its General Partner, Cedar Brook, Inc.

Date: June 14, 2001               By:/s/ A. Joseph Stern
                                     -------------------------------------------
                                          A. Joseph Stern, President,   Landlord

                                  3 Dimensional Pharmaceuticals, Inc.

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       40
<PAGE>

Date: June 14, 2001           By:/s/ Scott Horvitz
                                 --------------------------------------
                                      Scott Horvitz, Tenant
                                      Vice President, Finance and Administration

Initial: Landlord
         Tenant
Lease Version Date:  5-31-01

                                       41

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