Document:

Fifth Amendment to Lease Agreement

 Exhibit 10.1 
 FIFTH AMENDMENT TO LEASE AGREEMENT 
 This Fifth Amendment to Lease
Agreement (this “Fifth Amendment”) is made as of November 1, 2011, by and between ARE-2425/2400/2450 GARCIA BAYSHORE, LLC, a Delaware limited liability company (“Landlord”), and MAP PHARMACEUTICALS,
INC., a Delaware corporation (“Tenant”). 
 RECITALS 

A. Landlord and Tenant entered into that certain Lease Agreement dated June 10, 2004, as amended by that certain First Amendment to
Lease Agreement dated August 2, 2004, that certain Second Amendment to Lease Agreement (“Second Amendment”) dated July 26, 2006, that certain Third Amendment to Lease Agreement dated November 30, 2007, that certain
Fourth Amendment to Lease Agreement (“Fourth Amendment”) dated March 26, 2008 which Fourth Amendment was superseded in its entirety by that certain Amended and Restated Fourth Amendment to Lease Agreement (“Restated
Fourth Amendment”) dated July 15, 2008 (as amended, the “Lease”), pursuant to which Landlord currently leases to Tenant certain premises consisting of approximately 42,632 rentable square feet (the
“Premises”) located at 2400 Bayshore Parkway, Mountain View, California. As of the date hereof, Tenant has surrendered the Interim Premises (defined in the Restated Fourth Amendment). The Premises are more particularly described in
the Lease. Capitalized terms used herein without definition shall have the meanings defined for such terms in the Lease. 
 B.
Landlord and Tenant desire, subject to the terms and conditions set forth below, to among other things, (i) expand the Premises by adding approximately 8,372 rentable square feet in that certain building located at 2450 Bayshore Parkway,
Mountain View, California and (ii) extend the Base Term of the Lease to expire on June 30, 2013. 
 AGREEMENT

 NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by this reference, the
mutual promises and conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 

 

	1.	2450 Premises. In addition to the 2400 Premises, commencing on the 2450 Premises Commencement Date (as defined below), Landlord leases to Tenant, and
Tenant leases from Landlord, that certain portion of the building located at 2450 Bayshore Parkway, Mountain View, California, consisting of approximately 8,372 rentable square feet, as shown on Exhibit A attached hereto (the “2450
Premises”). As of the 2450 Premises Commencement Date, Exhibit A to this Fifth Amendment is hereby added to Exhibit A to the Lease. 

  

	2.	 Delivery. Landlord shall construct the 2450 Landlord’s Work (as defined in the Work Letter attached hereto as Exhibit C
(“Work Letter”)) in accordance with the Work Letter. Notwithstanding anything to the contrary in the Work Letter or this Fifth Amendment, Tenant acknowledges and agrees that the portion of the 2450 Premises designated as
“Existing Office” on Schedule A to the Work Letter attached hereto as Exhibit C (“Existing Office Space”) shall be delivered to Tenant in its AS-IS condition and Landlord shall have no obligation to make any
improvements to the Existing Office Space; provided, however, that Landlord shall clean the carpets in the Existing Office Space prior to delivery thereof. Landlord shall use reasonable efforts to deliver the 2450 Premises to Tenant with
Landlord’s 2450 Work Substantially Complete (as defined in the Work Letter) (“Delivery” or “Deliver”) on or before January 1, 2012 (“Target 2450 Premises Commencement Date”). If Landlord
fails to timely Deliver the 2450 Premises, Landlord shall not be liable to Tenant for any loss or damage resulting therefrom, and this Lease with respect to the 2450 Premises shall not be void or voidable. Notwithstanding the foregoing, if Landlord
does not Deliver the 2450 Premises to Tenant on or before the date that is 60 days after 

	 	
the Target 2450 Premises Commencement Date, for any reason other than Force Majeure delays, this Lease with respect to the 2450 Premises only may be terminated by Tenant by written notice to
Landlord. If Tenant does not elect to void this Lease with respect to the 2450 Premises on or before the fifth day after the expiration of such 60-day period, such right to void this Lease with respect to the 2450 Premises shall be waived and this
Lease shall remain in full force and effect. 

 The “2450 Premises Commencement Date” shall be the
date that Landlord Delivers the 2450 Premises to Tenant with Landlord’s 2450 Work Substantially Complete subject to the terms and conditions of the Work Letter. Upon request of Landlord, Tenant shall execute and deliver a written acknowledgment
of the 2450 Premises Commencement Date when the same is established in a form substantially similar to the form of the “Acknowledgement of Commencement Date” attached to the Lease as Exhibit D; provided, however,
Tenant’s failure to execute and deliver such acknowledgment shall not affect Landlord’s rights hereunder. 
 Except for
Landlord’s 2450 Work: (i) Tenant shall accept the 2450 Premises in their condition as of the 2450 Commencement Date, subject to all applicable Legal Requirements; (ii) Landlord shall have no obligation for any defects in the 2450
Premises; and (iii) Tenant’s taking possession of the 2450 Premises shall be conclusive evidence that Tenant accepts the 2450 Premises and that the 2450 Premises were in good condition at the time possession was taken. 

Tenant agrees and acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the
condition of all or any portion of the 2450 Premises, and/or the suitability of the 2450 Premises for the conduct of Tenant’s business, and Tenant waives any implied warranty that the 2450 Premises is suitable for the Permitted Use. 

 

	3.	Amended and New Definitions. 

 (a) As of the 2450 Premises Commencement Date, the following definitions on Page 1 of the Lease shall be amended and restated in their entirety or as follows: 

“Building: The 2400 Building and the 2450 Building.” 

“Premises: The 2400 Premises and the 2450 Premises.” 

“Rentable Area of Building: 42,632 sq. ft. for the 2400 Building and 42,632 sq. ft. for the 2450 Building.” 

“Building’s Share of Project: 43.08% for the 2400 Building and 43.08% for the 2450 Building.” 

“Tenant’s Share of Operating Expenses for the Building: shall mean 100% for the 2400 Building and 19.64% of the 2450
Building.” 
 “The defined term “Rentable Area of Premises” is deleted in its entirety.”

 (b) As of the 2450 Premises Commencement Date, the following definition shall be added to Page 1 of the Lease:

 “2450 Premises: That portion of the 2450 Building, containing approximately 8,372 rentable square feet
(“2450 Premises”), as determined by Landlord, as shown on Exhibit A.” 

  

			
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	4.	Term. The definition of Base Term on page 1 of the Lease is hereby amended and restated as follows: 

“Base Term”: (i) with respect to the Original Premises (as defined in the Second Amendment), beginning on
July 15, 2004 and ending at 11:59 p.m. on June 30, 2013, (ii) with respect to the Expansion Premises (as defined in the Second Amendment), beginning on August 1, 2006 and ending at 11:59 p.m. on June 30, 2013;
(iii) with respect to the Second Expansion Premises (as defined in the Restated Fourth Amendment), beginning on February 16, 2010 and ending at 11:59 p.m. on June 30, 2013; (iv) with respect to the 2450 Premises, beginning on the
2450 Premises Commencement Date and ending at 11:59 p.m. on June 30, 2013.” 
  

	5.	Base Rent. Tenant shall continue to pay Base Rent for the 2400 Premises as required pursuant to the Lease. Commencing on the 2450 Premises
Commencement Date, Tenant shall pay Base Rent for the 2450 Premises in the amount of $22,270 per month. Commencing on the first year anniversary of the 2450 Premises Commencement Date and annually thereafter (each a “2450 Adjustment
Date”), Base Rent applicable to the 2450 Premises shall be increased by multiplying the Base Rent payable immediately before such 2450 Adjustment Date by the Rent Adjustment Percentage and adding the resulting amount to the Base Rent
payable for the 2450 Premises immediately before such 2450 Adjustment Date. Base Rent for the 2450 Premises, as so adjusted, shall thereafter be due as provided herein. 

 

	6.	Right to Extend Term. Section 39 of the Lease is hereby deleted in its entirety and replaced with the following:

 “39. Right to Extend Term. 
 (a) 2400 Extension Rights. Tenant shall have 4 consecutive rights (each, an “2400 Extension Right”) to extend the term of the Lease with respect to the 2400 Premises for periods of
6 months each (each, an “2400 Extension Term”) on the same terms’ and conditions as this Lease (other than Landlord’s Work, Landlord’s Alteration Work, TI Allowance, Additional TI Allowance and any terms and
conditions to the extent applicable to the 2450 Premises) by giving Landlord written notice of its election to exercise each 2400 Extension Right at least 6 months prior, and no earlier than 12 months prior, to the expiration of the Base Term of the
Lease or the expiration of any prior 2400 Extension Term. Upon the exercise of a 2400 Extension Right, Base Rent shall continue to be payable at the rates set forth in the Lease for the 2400 Premises as adjusted from time to time. 

(b) Rights Personal. 2400 Extension Rights are personal to Tenant and are not assignable without Landlord’s consent, which may
be granted or withheld in Landlord’s sole discretion separate and apart from any consent by Landlord to an assignment of Tenant’s interest in the Lease. 
 (c) Exceptions. Notwithstanding anything set forth above to the contrary, 2400 Extension Rights shall not be in effect and Tenant may not exercise any of the 2400 Extension Rights: 

(i) during any period of time that Tenant is in Default under any provision of this Lease; or 

(ii) if Tenant has been in Default under any provision of this Lease 3 or more times, whether or not the Defaults are cured, during the
12 month period immediately prior to the date that Tenant intends to exercise an 2400 Extension Right, whether or not the Defaults are cured. 

  

			
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 (d) No Extensions. The period of time within which any 2400 Extension Rights may be
exercised shall not be extended or enlarged by reason of Tenant’s inability to exercise the 2400 Extension Rights. 
 (e)
Termination. The 2400 Extension Rights shall terminate and be of no further force or effect even after Tenant’s due and timely exercise of an 2400 Extension Right, if, after such exercise, but prior to the commencement date of an 2400
Extension Term, (i) Tenant fails to timely cure any default by Tenant under this Lease; or (ii) Tenant has Defaulted 3 or more times during the period from the date of the exercise of an 2400 Extension Right to the date of the commencement
of the 2400 Extension Term, whether or not such Defaults are cured. 
 (f) No Right to Extend 2450 Premises.
Notwithstanding anything to the contrary contained herein, in no event shall Tenant have the right to extend the Term of the Lease with respect to the 2450 Premises and the Term of the Lease with respect to the 2450 Premises shall expire on
June 30, 2013. 
  

	7.	Permitted Use. Notwithstanding anything to the contrary in the Lease, Tenant shall use the 2450 Premises solely for office use (and not for research and
development/laboratory use) and otherwise in compliance with Section 7 of the Lease. 

  

	8.	Asbestos Notification. 

 (a) Notification. Landlord hereby notifies Tenant of the presence of asbestos-containing materials (“ACMs”) and/or presumed asbestos-containing materials
(“PACMs”) within or about the 2400 Premises in the location identified in Exhibit B. 
 (b) Tenant
Acknowledgement. Tenant hereby acknowledges receipt of the notification in paragraph (a) of this Section 8 and understands that the purpose of such notification is to make Tenant, and any agents, employees, and contractors
of Tenant, aware of the presence of ACMs and/or PACMs within or about the 2400 Premises in order to avoid or minimize any damage to or disturbance of such ACMs and/or PACMs. 
         TSN         
 Tenant’s Initials 
 (c) Acknowledgement from
Contractors/Employees. Tenant shall give Landlord at least 14 days’ prior written notice before conducting, authorizing or permitting any of the activities listed below within or about the 2400 Premises, and before soliciting bids from
any person to perform such services. Such notice shall identify or describe the proposed scope, location, date and time of such activities and the name, address and telephone number of each person who may be conducting such activities. Thereafter,
Tenant shall grant Landlord reasonable access to the 2400 Premises to determine whether any ACMs or PACMs will be disturbed in connection with such activities. Tenant shall not solicit bids from any person for the performance of such activities
without Landlord’s prior written approval. Upon Landlord’s request, Tenant shall deliver to Landlord a copy of a signed acknowledgement from any contractor, agent, or employee of Tenant acknowledging receipt of information describing the
presence of ACMs and/or PACMs within or about the Premises in the locations identified in Exhibit B prior to the commencement of such activities. Nothing in this Section 8 shall be deemed to expand Tenant’s rights under the
Lease or otherwise to conduct, authorize or permit any such activities. 
 (i) Removal of thermal system
insulation (“TSI”) and surfacing ACMs and PACMs (i.e., sprayed-on or troweled-on material, e.g., textured ceiling paint or fireproofing material); 

(ii) Removal of ACMs or PACMs that are not TSI or surfacing ACMs or PACMs; or 

  

			
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 (iii) Repair and maintenance of operations that are likely to disturb ACMs or PACMs.

  

	9.	Miscellaneous. 

(a) This Fifth Amendment is the entire agreement between the parties with respect to the subject matter hereof and supersedes all
prior and contemporaneous oral and written agreements and discussions with respect to the matters addressed herein. This Fifth Amendment may be amended only by an agreement in writing, signed by the parties hereto. 

(b) This Fifth Amendment is binding upon and shall inure to the benefit of the parties hereto, their respective agents, employees,
representatives, officers, directors, divisions, subsidiaries, affiliates, assigns, heirs, successors in interest and shareholders. 
 (c) This Fifth Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when taken together shall constitute one and the same instrument.
The signature page of any counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided such signature page is attached to any other counterpart identical thereto except having additional signature
pages executed by other parties to this Fifth Amendment attached thereto. 
 (d) Landlord and Tenant each represent and
warrant that it has not dealt with any broker, agent or other person (collectively “Broker”) other than Cornish & Carey Commercial Newmark Knight Frank in connection with this Fifth Amendment. Landlord and Tenant each
hereby agree to indemnify and hold the other harmless from and against any claims by any Broker (other than Cornish & Carey Commercial Newmark Knight Frank) claiming a commission or other form of compensation by virtue of having dealt with
Tenant or Landlord, as applicable, with regard to this Fifth Amendment. 
 (e) Except as amended and/or modified by this
Fifth Amendment, the Lease is hereby ratified and confirmed and all other terms of the Lease shall remain in full force and effect unaltered and unchanged by this Fifth Amendment. In the event of any conflict between the provisions of this Fifth
Amendment and the provisions of the Lease, the provisions of this Fifth Amendment shall prevail. Whether or not specifically amended by this Fifth Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to
give effect to the purpose and intent of this Fifth Amendment. 

  

			
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 IN WITNESS WHEREOF, this Fifth Amendment to Lease has been duly executed and
delivered by Landlord and Tenant as of the date first above written. 
  

									
	TENANT:
	
	 MAP PHARMACEUTICALS, INC.,
 a Delaware corporation

		
	By:	 	 /s/    Timothy S. Nelson

	Its:	 	 President and Chief Executive Officer

	
	LANDLORD:
	
	 ARE-2425/2400/2450 GARCIA BAYSHORE, LLC,
 a Delaware limited liability company

		
	By:	 	ALEXANDRIA REAL ESTATE EQUITIES, L.P.,
		 		 	 a Delaware limited partnership,
 managing member

				
		 		 	By:	 	ARE-QRS CORP.,
		 		 		 	a Maryland corporation,
		 		 		 	general partner
					
		 		 		 	By:	 	 /s/ Eric S. Johnson

		 		 		 	Its:	 	 Vice President

		 		 		 		 	 Real Estate Legal Affairs

  

			
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CONFIDENTIAL – DO NOT COPY OR DISTRIBUTENon-Employee Director Compensation Plan

 EXHIBIT 10.3 
 OPTIMUMCOMPANY COMPANY HOLDINGS, INC. 
 NON-EMPLOYEE DIRECTOR COMPENSATION
PLAN 
 OptimumBank Holdings, Inc. hereby establishes the Non-Employee Director Compensation Plan (the “Plan”),
effective as of January 1, 2012. All Common Shares issued under and subject to the terms of this Plan will be issued under OptimumBank Holdings, Inc. 2011 Equity Incentive Plan and/or its successor plans and shall be deemed to be “Bonus
Shares” for purposes of such Plan. 
 1. Definitions. Whenever the following terms are used in the Plan they shall
have the meanings specified below unless the context clearly indicates to the contrary: 
  

	 	(a)	“Administrator”: The Board. 

  

	 	(b)	“Bank”: OptimumBank, or any successor or successors thereto. 

  

	 	(c)	“Board”: The Board of Directors of the Company or OptimumBank 

  

	 	(d)	“Common Shares”: The Company’s Common Stock, par value $.01 per share. 

 

	 	(e)	“Company”: OptimumBank Holdings, Inc. or any successor or successors thereto. 

 

	 	(f)	“Director”: An individual duly elected or chosen as a member of the Board who is not an officer or employee of the Company or the Bank.

  

	 	(g)	“Fair Market Value”: With respect to a Common Share, (i) the last reported closing price for a Common Share on The NASDAQ Capital Market (or any
appropriate national securities or over-the-counter market if the Common Shares are no longer listed on The NASDAQ Capital Market) on the last business day of the Plan Quarter, or if there was no sale of Common Shares so reported for such day, on
the most recently preceding day on which there was such a sale or (ii) if the stock is not publicly traded, the fair market value for a Common Share for the last business day of the Plan Quarter, as determined by the Board.

  

	 	(h)	“Fees”: Compensation payable to each Director for service on the Board and Board committees in the amounts and subject to the conditions set forth in
paragraph 4 hereof. 

  

	 	(i)	“Plan”: The Plan set forth in this instrument, as it may from time to time be amended. 

 

	 	(j)	“Plan Quarter”: Each 3-month period beginning January 1 and ending December 31. 

 

	 	(k)	“Quarterly Fee”: The dollar value of the Fees payable to a Director for each Plan Quarter as determined pursuant to paragraph 4 hereof.

 2. Purpose. The purpose of the Plan is to provide for payment to Directors of a substantial portion of
their Fees in Common Shares in order to align the interests of such Directors with the stockholders of the Company and thereby promote the long-term success and growth of the Company. 

3. Participation. Participation by a Director in the Plan shall be automatic. 

  
 Page 1 of 3

 4. Amount of Fees. Commencing on or after January 1, 2012, the amount of
Quarterly Fees payable in cash and Common Shares to each Director is as follows: 
  

	 	(a)	(i) $1,000 for each Board meeting attended by such Director during the Plan Quarter; plus 

(ii) $200 for each Audit Committee meeting attended by such Director during the Plan Quarter if such Director serves as a member of the
Audit Committee, or $250 for each Audit Committee meeting attended by such Director during the Plan Quarter if such Director serves as Chairperson of the Audit Committee; plus 
 (iv) $100 for each Compensation Committee meeting attended by such Director during the Plan Quarter if such Director serves as a member of the Compensation Committee, or $125 for each Compensation
Committee meeting attended by such Director during the Plan Quarter if such Director serves as Chairperson of the Compensation Committee. 
 (b) Fees in such dollar amount as shall be set by the Board by Board resolution with respect to Plan Quarters subsequent to 2012, in each case calculated as set forth in paragraph 5 hereof. 

(c) Directors who are both Company Directors and Bank Directors shall not receive Fees under this paragraph 4 for service in both
capacities. 
 5. Form of Payment of Fees. As soon as practicable after each Plan Quarter, the Company shall issue to each
Director Fees for such Plan Quarter as follows: 
  

	 	(a)	25% of the Quarterly Fee shall be issued in cash; 

  

	 	(b)	75% of the Quarterly Fee shall be issued in the form of whole Common Shares equal to the sum of (i) the Quarterly Fee divided by the Fair Market Value for the Plan
Quarter. To the extent that the application of the foregoing formula would result in the issuance of fractional shares for a Plan Quarter, no fractional Common Shares shall be issued, but instead the Company shall round up such fraction to a whole
Common Share, which shall be added to the number of whole Common Shares issued to such Director for such Plan Quarter. 

 6. Administration. The Plan shall be administered by the Administrator. The Administrator shall have such powers as may be necessary to discharge its duties hereunder. The Administrator may, from
time to time, employ agents and delegate to them such administrative duties as it sees fit, and may from time to time consult with legal counsel who may be counsel to the Company. No member of the Administrator shall act in respect of his or her own
Common Shares. All decisions and determinations by the Administrator shall be final and binding on all parties. All decisions of the Administrator shall be made by the vote of the majority, including actions in writing taken without a meeting.

 7. Amendment and Termination. The Board may alter or amend the Plan from time to time or may terminate it in its
entirety; provided, however, that no such action shall, without the consent of a Director, affect the rights in any Common Shares issued to which such Director is entitled under the Plan. In the event of any change in the outstanding Common Shares
by reason of (i) any stock dividend, stock split, combination of shares, recapitalization or any other change in the capital structure of the Company, (ii) any merger, consolidation, spin-off, spin-out, split-up, reorganization, partial or
complete liquidation or other assets, issuance of rights or warrants to purchase securities, or (iii) any other corporate transaction or event having an effect similar to any of the foregoing, the number or kind of Common Shares that may be
issued under the Plan shall automatically be adjusted so that the proportionate interest of the Directors shall be maintained as before the occurrence of such event. Such adjustment shall be conclusive and binding for all purposes with respect to
the Plan. Without limiting the generality of the foregoing, the Board may amend the Plan to eliminate provisions which are no longer necessary as a result of changes in tax or securities laws or regulations or in the interpretation thereof.

  
 Page 2 of 3

 8. Shares Subject to Plan. The Common Shares that may be issued under the Plan may be
shares of original issue or treasury shares or a combination of both. 
 9. General Provisions. 

 

	 	(a)	No Continuing Right as Director. Neither the adoption or operation of the Plan, nor any document describing or referring to the Plan, or any part thereof, shall
confer upon any Director any right to continue as a member of the Board of the Company or the Bank. 

  

	 	(b)	Restrictions on Shares and Rights to Shares. Except for any restrictions required by law, a Director shall have all rights of a stockholder with respect to his
or her Shares. No rights to Shares shall be assigned, pledged, hypothecated or otherwise transferred by a Director or any other person, voluntarily or involuntarily, other than (i) by will or the laws of descent and distribution, or
(ii) pursuant to a domestic relations order meeting the definition of a qualified domestic relations order under the Code. No person shall have any right to encumber, pledge or dispose of any other interest herein or right to receive payments
hereunder, nor shall such interests or payments be subject to seizure, attachment or garnishment for the payments of any debts, judgments, alimony or separate maintenance obligations or be transferable by operation of law in the event of Company
bankruptcy, insolvency or otherwise, all payments and rights hereunder being expressly declared to be nonassignable and nontransferable. 

  

	 	(c)	Governing Law. The provisions of the Plan shall be governed by and construed in accordance with the laws of the State of Florida applicable to contracts executed
in and to be performed within the State. 

  

	 	(d)	Withholding Taxes. To the extent that the Company is required to withhold Federal, state or local taxes in connection with any component of a Director’s
compensation it shall be a condition to the receipt of any Common Shares that the Director make arrangements satisfactory to the Company for the payment of the balance of such taxes required to be withheld, which arrangement may include
relinquishment of the Common Shares. 

  

	 	(e)	Miscellaneous. Headings are given to the paragraphs of the Plan solely as a convenience to facilitate reference. Such headings, numbering and paragraphing shall
not in any case be deemed in any way material or relevant to the construction of the Plan or any provisions thereof. The use of the singular shall also include within its meaning the plural, and vice versa. 

Approved by Compensation Committee: March 27, 2012 
 Approved by Board: March 27, 2012 
 Effective Date: January 1, 2012 

  
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