Document:

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                                                                   Exhibit 10.10

SR 95-012

                          SPONSORED RESEARCH AGREEMENT

         Agreement, made this 21th day of September, 1995, by and between THE
UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER (hereinafter referred to as
"CANCER CENTER"), a component institution of The University of Texas System
(hereinafter referred to as "SYSTEM"), located in Houston, Texas, and Introgen
Therapeutics (hereinafter referred to as "SPONSOR"), located in Austin, Texas.

                                   WITNESSETH:

         WHEREAS, SPONSOR is the licensee of the Adenovirus Vector Expression
Wild-Type p53 which has potential utilization in patient care and treatment; and

         WHEREAS, CANCER CENTER has research facilities and situations which
would allow clinical investigation and study of the "Modification of Tumor
Suppressor Gene Expression in Head and Neck Squamous Cell Carcinoma (HSCC) with
an Adenovirus Vector Expression Wild-Type p53" as described in Exhibit I
hereinafter referred to as ("Research"), a copy of which is attached hereto and
incorporated herein by reference; and

         WHEREAS, both SPONSOR and CANCER CENTER consider it necessary and
desirable and desirable to perform the Research;

         NOW, THEREFORE, the parties agree as follows:

1. Evaluation. SPONSOR agrees to engage the services of CANCER CENTER as an
independent contractor to perform the Research. The Research will be under the
supervision of Gary L. Clayman, M.D. (Principal Investigator) at CANCER CENTER,
with the assistance of appropriate associates and colleagues at CANCER CENTER as
may be required.

2. Research. CANCER CENTER agrees as an independent contractor to conduct the
Research. Such Research was originally approved by CANCER CENTER in accordance
with CANCER CENTER policy and may be subsequently amended only in accordance
with CANCER CENTER policy and the written agreement of CANCER CENTER and SPONSOR
as provided for in Article 16 herein below.

3. Invention and Patents.

         a. For all purposes herein, "Invention" shall mean any discovery,
concept or idea whether or not patentable or copyrightable, which (i) arises out
of work performed pursuant to the obligations of this Agreement; (ii) is
conceived and reduced to practice during the term of the Agreement as defined in
Article 14 hereinbelow; and (iii) includes but is not limited to processes,
methods, software, formulae, techniques, compositions of matter, devices, and
improvements thereof and know-how relating thereto. Inventions made solely by
the Principal Investigator and/or other CANCER CENTER personnel as identified in
Article 1 hereinabove or agents of CANCER CENTER shall be the sole property of

<PAGE>   2

CANCER CENTER. Inventions made jointly by employees or agents of CANCER CENTER
and SPONSOR shall be jointly owned by CANCER CENTER and SPONSOR.

         b. In the event that an Invention is made, either solely by employees
ro agents of CANCER CENTER or jointly by employees or agents of CANCER CENTER
and SPONSOR, CANCER CENTER and SPONSOR agree to give notice of such Invention to
each other within thirty (30) days of the identification of such Invention.
Within thirty (30) days of notice of Invention, CANCER CENTER and SPONSOR will
thereupon exert their best reasonable efforts in cooperation with each other to
investigate, evaluate and determine to the mutual satisfaction of both parties,
the disposition of rights to the Invention, including whether, by whom, and
where any patent applications are to be filed.

         c. If, after consultation with SPONSOR, it is agreed by the parties
that a patent application should be filed, CANCER CENTER will prepare and file
appropriate United States and foreign patent applications on Inventions made
under this Agreement, and SPONSOR will pay the cost of preparing, filing and
maintenance thereof. If SPONSOR notified CANCER CENTER that it does not intend
to pay the costs of an application, or if SPONSOR does not respond or make an
effort to agree with CANCER CENTER on the disposition of rights to the
INVENTION, THEN cancer center MAY FILE SUCH APPLICATION AT ITS OWN EXPENSE, AND
sponsor shall have no rights to such Invention. CANCER CENTER will provide
SPONSOR a copy of the application filed for which SPONSOR has paid the cost of
filing, as well as copies of any documents received or filed during prosecution
thereof. SPONSOR agrees to maintain any such application in confidence until it
is published by CANCER CENTER or by the respective patent office.

         d. Under the terms the "Patent and Technology License Agreement between
CANCER CENTER and Introgen (Intron) Therapeutics" dated effective July 20, 1994,
CANCER CENTER hereby licenses to SPONSOR an exclusive, world-wide,
royalty-bearing license to invention (as well as patent applications, patents,
and copyrights thereon) for commercial purposes, provided that SPONSOR shall pay
all costs and expenses associated with patent and copyright filing, prosecution,
issuance, and maintenance. SPONSOR shall have thirty (30) days from written
notice of Invention from CANCER CENTER pursuant to Article 3(b) hereinabove, to
give written notice to CANCER CENTER to include any invention in the above
referenced licensed agreement.

4. Confidentiality. Because CANCER CENTER and SPONSOR will be cooperating with
each other in this Research, and because each may reveal to the other in the
course of this Research certain confidential information, CANCER CENTER and
SPONSOR agree to hold any confidential information which (a) is obtained during
the course of this work and (b) is related thereto and (c) is marked as
"CONFIDENTIAL" in confidence, and each party will not disclose same to any third
party without the express written consent of the other party to this Agreement.
This requirement shall remain in force for a period of three (3) years following
completion of work under this Agreement. Nothing in this paragraph shall in any
way restrict the rights of either CANCER CENTER or SPONSOR to use, disclose or
otherwise deal with any information which:

                                       -2-

<PAGE>   3

         a. can be demonstrated to have been in public domain as of the
effective date of this Agreement or comes into the public domain through the
term of this Agreement through no act of the recipient; or

         b. can be demonstrated to have been known to the recipient prior to the
execution of this Agreement; or

         c. can be demonstrated to have been rightfully received by the
recipient after disclosure under this Agreement from a third party who did not
require the recipient to hold it in confidence or limit its use and who did not
acquire it, directly or indirectly, under obligation of confidentiality to the
disclosing party; or

         d. shall be required for disclosure to Federal regulatory agencies
pursuant to approval for use; or

         e. is independently invented by researchers of the recipient, which in
the case of CANCER CENTER includes SYSTEM, who have not had access to the
information provided to the recipient hereunder.

Nothing herein is intended to give SPONSOR the right to use for any purpose
pre-existing confidential information of CANCER CENTER. Notwithstanding the
confidentiality obligations of this Agreement, nothing herein shall prevent
CANCER CENTER and any other component of SYSTEM from using any information
generated hereunder for ordinary research and educational purposes of a
university.

5. Publication Rights. Notwithstanding the provisions of Article 4 of this
Agreement, CANCER CENTER may publish scientific papers relating to the
collaborative research performed under this Agreement. In the event that CANCER
CENTER wishes to publish, CANCER CENTER shall notify SPONSOR of its desire to
publish [*] in advance of publication and shall furnish to SPONSOR a written
description of the subject matter of the publication in order to permit SPONSOR
to review and comment thereon.

6. Publicity. CANCER CENTER acknowledges SPONSOR'S intention to distribute
periodically information releases and announcements to the news media regarding
the progress of research hereunder. SPONSOR shall not release such materials
containing the name of CANCER CENTER or any of its employees without prior
written approval by an authorized representative of CANCER CENTER, and said
approval shall not be unreasonably withheld. Should CANCER CENTER reject the
news release, CANCER CENTER and SPONSOR agree to discuss the reasons for CANCER
CENTER's rejection, and every effort shall be made to develop an appropriate
informational news release within the bounds of accepted academic practices.
SPONSOR reserves the same right in the event that CANCER CENTER desires to
distribute a news release concerning the research program. Nothing herein shall
be construed as prohibiting CANCER CENTER or SPONSOR from reporting on this
study to a governmental agency.

7. Responsibility. The parties each agree to assume individual responsibility
for the actions and omissions of their respective employee, agents and assigns
in conjunction with this evaluation.

     [*]   Certain information on this page has been omitted and filed
           separately with the Commission. Confidential treatment has been
           requested with respect to the omitted portions.

                                       -3-

<PAGE>   4

8. Independent Contractor. SPONSOR will not have the right to direct or control
the activities of CANCER CENTER in performing the services provided herein, and
CANCER CENTER shall perform services hereunder only as an independent
contractor, and nothing herein contained shall be construed to be inconsistent
with this relationship or status. Under no circumstances shall CANCER CENTER be
considered to be an employee or agent of SPONSOR. This Agreement shall not
constitute, create or in any way be interpreted as a joint venture, partnership
or formal business organization of any kind.

9. Title to Equipment. CANCER CENTER shall retain title to all equipment
purchased and/or fabricated by it with funds provided by SPONSOR under this
Agreement.

10. Survivorship. The provisions of Articles 3, 4, 5, 6, and 12 shall survive
any expiration or termination of this Agreement.

11. Assignment. This Agreement may not be assigned by either party without the
prior written consent of the other party; provided, however, that SPONSOR may
assign this Agreement to any purchaser or transferee of all or substantially all
of SPONSOR's business upon prior written notice to CANCER CENTER.

12. Indemnification. CANCER CENTER shall, to the extent authorized under the
Constitution and the laws of the State of Texas, hold SPONSOR harmless from
liability resulting from the negligent acts or omissions of CANCER CENTER, its
agents or employees pertaining to the activities to be carried out pursuant to
the obligations of this Agreement; provided, however, that CANCER CENTER shall
not hold SPONSOR harmless from claims arising out of the negligence of SPONSOR,
its officers, agents or any person or entity not subject to CANCER CENTER's
supervision or control.

SPONSOR shall indemnify and hold harmless SYSTEM, CANCER CENTER, their regents,
officers, agents and employees from any liability or loss resulting from
judgments or claims against them arising out of the activities to be carried out
pursuant to the obligations of this Agreement or the use by SPONSOR of the
results of the Research, provided, however, that the following is excluded from
SPONSOR's obligation to indemnify and hold harmless:

         a. the negligent failure of CANCER CENTER to comply with any applicable
governmental requirements; or

         b. the negligence or willful malfeasance by a regent, officer, agent or
employee of CANCER CENTER or SYSTEM.

13. Award. SPONSOR agrees to pay CANCER CENTER a fee equal to [ * ]. This fee,
as shown [ * ] in Exhibit II, which is attached hereto and is incorporated
herein by reference, for information only, shall be paid by Sponsor at such
times and in such amounts as mutually agreed upon between Sponsor and Cancer
Center, but at a minimum in the following amounts on the following dates:

[ * ]

         [*]    Certain information on this page has been omitted and filed
                separately with the Commission. Confidential treatment has been
                requested with respect to the omitted portions.

                                       -4-

<PAGE>   5

14. Basic Term. This Agreement shall become effective as of the date first
hereinabove written and unless earlier terminated as hereinafter provided, shall
continue in force for a period of Five (5) years after the same.

15. Default and Termination. In the event that the patient enrollment and
treatment is completed earlier than estimated, SPONSOR may terminate the
agreement provided that all costs and fees as herein agreed have been paid by
SPONSOR. In the event that FDA or NIH or other governing regulatory agency
requests the clinical study herein contemplated be halted or suspended, then
SPONSOR and CANCER CENTER agree to terminate this Agreement

16. Entire Agreement. The parties acknowledge that this Agreement and the
attached Exhibits hereto represent the sole and entire Agreement between the
parties hereto pertaining to the Research and that such supersedes all prior
Agreements, understandings, negotiations and discussions between the parties
regarding same, whether oral or written. There are no warranties,
representations or other Agreements between the parties in connection with the
subject matter hereof except as specifically set forth herein. No supplement,
amendment, alteration, modification, waiver or termination of this Agreement
shall be binding unless executed in writing by the parties hereto.

17. Reform of Agreement. If any provision of this Agreement is, becomes or is
deemed invalid, illegal or unenforceable in any United States jurisdiction, such
provision shall be deemed amended to conform to applicable laws so as to be
valid and enforceable; or if it cannot be so amended without materially altering
the intention of the parties, it shall be stricken, and the remainder of this
Agreement shall remain in full force and effect.

18. Notices. Any notices, statements, payments, or reports required by this
Agreement shall be considered given if sent by United States Certified Mail,
postage prepaid and addressed as follows:

         If to CANCER CENTER:

                  Donna S. Gilberg, CPA
                  Manager, Sponsored Programs
                  The University of Texas M.D. Anderson Cancer Center
                  1515 Holcombe Blvd.
                  Houston, Texas  77030

         If to SPONSOR:

                  David Nance
                  Managing Partner
                  Texas Biomedical Development Partners
                  301 Congress Avenue, Suite 2025
                  Austin, Texas  78701

                                       -5-

<PAGE>   6

19. Captions. The captions in this Agreement are for convenience only and shall
not be considered a part of or affect the construction or interpretation of any
provision of this Agreement.

20. Governing Law. This Agreement shall be governed and interpreted in
accordance with the substantive laws of the State of Texas and with applicable
laws of the United States of America.

                                       -6-

<PAGE>   7

         IN WITNESS WHEREOF, CANCER CENTER and SPONSOR entered into this
Agreement effective as of the date first hereinabove written and have executed
two (2) originals each of which are of equal dignity.

                                 THE UNIVERSITY OF TEXAS
INTROGEN THERAPEUTICS            M.D. ANDERSON CANCER CENTER

By:  /s/ DAVID NANCE             By  /s/ DONNA S. GILBERG
     ---------------------           -----------------------------------------
         David Nance             Donna S. Gilberg, CPA
         Managing Partner        Manager, Sponsored Programs

                                 I have read this agreement and
                                 understand my obligations hereunder:

                                 By:  /s/ GARY L. CLAYMAN
                                      ----------------------------------------
                                          Gary L. Clayman, D.D.S., M.D.
                                          Principal Investigator

                                 By:  /s/ HELMUTH GOEPFERT
                                      ----------------------------------------
                                          Helmuth Goepfert, M.D.
                                          Ad interim Head, Division of Surgery

Payment Mailing Address:

The University of Texas
M.D. Anderson Cancer Center
Attn.:  Manager, Sponsored Programs
P.O. Box 297402
Houston, Texas  77297

Tax ID:  74-6001118-A1

                                       -7-

<PAGE>   8

                                    PROTOCOL

                                      [ * ]

     [*]   Certain information on this page has been omitted and filed
            separately with the Commission. Confidential treatment has been
            requested with respect to the omitted portions.

                                       -8-

<PAGE>   9

                                 AMENDMENT NO. 1

                                       TO

                               RESEARCH AGREEMENT

         AMENDMENT, effective this 1st day of October, 1995, between THE
UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER (hereinafter referred to as
"CANCER CENTER"), a component of THE UNIVERSITY OF TEXAS SYSTEM (hereinafter
referred to as "SYSTEM") located at Houston, Texas, INTROGEN THERAPEUTICS
(hereinafter referred to as "SPONSOR"), of the Sponsored Research Agreement made
by these parties and dated the 21st day of September, 1995, regarding research
on the evaluation and study of the "Modification of Tumor Suppressor Gene
Expression in Head and Neck Squamous Cell Carcinoma (HSCC) with an Adenovirus
Vector Expression Wild-Type p53".

1. CANCER CENTER and SPONSOR agree that the Confidentiality provision addressed
in Paragraph 4(d) of the original Agreement be revised to the following:

         d.       Shall be required to be disclosed by law or regulation,
                  including without Stations for disclosure to Federal
                  regulatory agencies pursuant to approval for use; or

2. CANCER CENTER and SPONSOR agree that the Award and payment schedule addressed
in Paragraph 13 of the original Agreement be revised to the following:

         AWARD. During the basic term of this Agreement as set forth below and
         in consideration for CANCER CENTER's performance of the Research,
         SPONSOR agrees to pay CANCER CENTER a fee equal to [ * ]:

         a.       SPONSOR will pay CANCER CENTER [ * ].

         b.       SPONSOR will pay CANCER CENTER's [ * ].

         [ * ]

         A third party clinical research organization ("CRO") may be engaged to
assist in conducting the Research, either at the request of CANCER CENTER or
SPONSOR. In that event, [ * ].

3. CANCER CENTER and SPONSOR agree that the Basic Term addressed in Paragraph 14
of the original Agreement be revised to the following:

         BASIC TERM. This Agreement becomes effective as of the date first
         written above and continues in force through December 31, 1996.
         Thereafter, this Agreement can be extended for additional annual
         periods upon the mutual written consent of CANCER CENTER and SPONSOR.

         [*]    Certain information on this page has been omitted and filed
                separately with the Commission. Confidential treatment has been
                requested with respect to the omitted portions.
<PAGE>   10

4. ACCESS TO INFORMATION. All results of and information arising from the
Research shall be made available and accessible to SPONSOR by CANCER CENTER
SPONSOR shall have the right to obtain copies or duplicates of such results and
information on a timely basis, in either written or electronic form, upon
SPONSOR giving CANCER CENTER reasonable notice of SPONSOR's desire to obtain
such results and information.

         OTHERWISE, the terms and provisions of the original Agreement entered
into on the 21st day of September, 1995 by and between the parties hereto shall
remain in full force and effect, provided, however, that in the event of a
conflict in the terms and conditions between this Amendment No. 1 and the
Sponsored Research Agreement, the terms and conditions of this Amendment shall
prevail.

         IN WITNESS WHEREOF, the parties have executed two (2) original
counterparts of this Amendment No. 2, each of which are of equal dignity and
effective as of the date first hereinabove written.

                                       -2-

<PAGE>   11

         IN WITNESS WHEREOF, the parties have executed two (2) original
counterparts of this Amendment No. 2, each of which are of equal dignity and
effective as of the date first hereinabove written.

INTROGEN THERAPEUTICS             THE UNIVERSITY OF TEXAS
                                  M.D. ANDERSON CANCER CENTER

By:  /s/ DAVID NANCE              By  /s/ DONNA S. GILBERG
     -----------------                 ----------------------------------------
         David Nance                       Donna S. Gilberg, CPA
         President                         Manager, Sponsored Programs

Date:    /12/28/95                Date:  12/31/95

                                  I have read this agreement and understand my
                                  obligations hereunder:

                                  By:  /s/ GARY L. CLAYMAN
                                       ----------------------------------------
                                           Gary L. Clayman, D.D.S., M.D.
                                           Principal Investigator

                                  By:  /s/ HELMUT GOEPFERT
                                       ----------------------------------------
                                           Helmuth Goepfert, M.D.
                                           Ad Interim Head, Division of Surgery

Payment Mailing Address:

The University of Texas
M.D. Anderson Cancer Center
Attn.:  Manager, Sponsored Programs
P.O. Box 297402
Houston, Texas  77297

Tax ID:  74-6001118-A1

                                       -3-<PAGE>   1
                                                                  Exhibit 10.11

SR 93-04

                          SPONSORED RESEARCH AGREEMENT

         Agreement, made this 11th day of February, 1993, by and by and between
THE UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER (hereinafter referred to as
"CANCER CENTER"), a component institution of The University of Texas System
(hereinafter referred to as "SYSTEM"), located in Houston, Texas, and Texas
Biomedical Development Partners (hereinafter referred to as "SPONSOR"), located
in Austin, Texas.

                                   WITNESSETH:

         WHEREAS, CANCER CENTER has research facilities and situations which
would allow investigation and study of the "Development of Therapeutic Treatment
and Prevention of Lung Cancer" an described in Exhibit I hereinafter referred to
as ("Research"), a copy of which in attached hereto and incorporated herein by
reference; and

         WHEREAS, both SPONSOR and CANCER CENTER consider it necessary and
desirable to perform the Research;

         NOW, THEREFORE , the parties agree as follows:

         1. Evaluation. SPONSOR agrees to engage the services of CANCER CENTER
as an independent contractor to perform the Research. The Research will be under
the supervision of Jack A. Roth, M.D. (Principal Investigator) at CANCER CENTER,
with the assistance of appropriate associates and colleagues at CANCER CENTER as
may be required.

         2. Research. CANCER CENTER agrees as an independent contractor to
conduct the Research. Such Research was originally approved by CANCER CENTER in
accordance with CANCER CENTER policy and may be subsequently amended only in
accordance with CANCER CENTER policy and the written agreement of CANCER CENTER
and SPONSOR as provided for in Article 15 herein below.

         3. Invention and Patents.

                  a. For all purposes herein, "Invention" shall mean any
discovery, concept or idea whether or not patentable or copyrightable, which (i)
arises out of work performed pursuant to the obligations of this Agreement; (ii)
is conceived and reduced to practice during the term of the Agreement as defined
in Article 13 herein below; and (iii) includes but is not limited to processes,
methods, software, formula, techniques, compositions of matter, devices, and
improvements thereof and know-how relating thereto. Inventions made solely by
the Principal investigator and/or other CANCER CENTER personnel
 as identified in Article I hereinabove or agents of CANCER CENTER shall be the
sole property of CANCER CENTER.

<PAGE>   2

                  b. In the event that an invention is made, CANCER CENTER
agrees to include such invention in the option Agreement of December 17, 1992
(attached hereto as Exhibit II) previously entered into by CANCER CENTER and
SPONSOR and give notice of such Invention to SPONSOR within thirty (30) days of
the identification of such Invention.

         4. Confidentiality. In the course of work performed pursuant to the
Research under this Agreement, should either party provide confidential
information to the other party, the recipient party shall, until three (3) years
after the termination of this Agreement, maintain the confidentiality of that
information as it maintains the confidentiality of its own confidential
information, and shall not disclose such confidential information to any other
party, nor shall the recipient party disclose the disclosing party's
confidential information to the recipient's employees other than those employees
having a "need-to-know". Confidential information shall be clearly marked as
such. If disclosed orally, the party making the disclosure shall be responsible
for clearly informing the recipient party of the confidentiality of the
information disclosed. Notwithstanding the other provisions of this paragraph,
nothing disclosed hereunder shall be construed as confidential information
which:

                  a. is or becomes available to the public (except by a breach
of this Agreement by a party hereto);

                  b. is rightfully received from another party not under
obligation of confidentiality to the disclosing party;

                  c. is not known by the recipient party, or is independently
developed by the recipient party by persons without access to the confidential
information;

                  d. is approved for release by the party designating the
information an confidential;

                  e. is not identified as confidential at the time of
disclosure;

                  f. is not in writing or physical form at time of disclosure or
reduced to a written or physical form and identified as confidential within
thirty (30) days of disclosure; or

                  g. is required to be disclosed under the laws of the United
States of America or the State of Texas or other governmental bodies, provided
that the parties shall first exhaust all reasonable measures available to
protect the confidentiality of such information upon disclosure.

         5. Publication Rights. Notwithstanding the provisions of Article 4 of
this Agreement, CANCER CENTER may publish scientific papers relating to the
collaborative research performed under this Agreement. In the event that CANCER
CENTER wishes to publish, CANCER CENTER shall notify SPONSOR of its desire to
publish [*] in advance of publication and shall furnish to SPONSOR a written
description of the subject matter of the publication in order to permit SPONSOR
to review and comment thereon.

         [*]    Certain information on this page has been omitted and filed
                separately with the Commission. Confidential treatment has been
                requested with respect to the omitted portions.

                                       -2-

<PAGE>   3

         6. Publicity. CANCER CENTER acknowledges SPONSOR's intention to
distribute periodically informational releases and announcements to the news
media regarding the progress of research hereunder. SPONSOR shall not release
such materials containing the name of CANCER CENTER or any of its employees
without prior written approval by an authorized representative of CANCER CENTER,
and said approval shall not be unreasonably withheld. Should CANCER CENTER
reject the news release, CANCER CENTER and SPONSOR agree to discuss the reasons
for CANCER CENTER's rejection, and every effort shall be made to develop an
appropriate informational news release within the bounds of accepted academic
practices. SPONSOR reserves the same right in the event that CANCER CENTER
desires to distribute a news release concerning the research program. Nothing
herein shall be construed as prohibiting CANCER CENTER or SPONSOR from reporting
on this study to a governmental agency.

         7. Responsibility. The parties each agree to assume individual
responsibility for the actions and omissions of their respective employees,
agents and assigns in conjunction with this evaluation.

         8. Independent Contractor. SPONSOR will not have the right to direct or
control the activities of CANCER CENTER in performing the services provided
herein, and CANCER CENTER shall perform services hereunder only as an
independent contractor, and nothing herein contained shall be construed to be
inconsistent with this relationship or status. Under no circumstances shall
CANCER CENTER be considered to be an employee or agent of SPONSOR. This
Agreement shall not constitute, create or in any way be interpreted as a joint
venture, partnership or formal business organization of any kind.

         9. Title to Equipment. CANCER CENTER shall retain title to all
equipment purchased and/or fabricated by it with funds provided by SPONSOR under
this Agreement.

         10. Survivorship. The provisions of Article 3, 4, 5, 6, and 12 shall
survive any expiration or termination of this Agreement.

         11. Assignment. This Agreement may not be assigned by either party
without the prior written consent of the other party; provided, however, that
SPONSOR may assign this Agreement to any purchaser or transferee of all or
substantially all of SPONSOR's business upon prior written notice to CANCER
CENTER.

         12. Indemnification. CANCER CENTER shall, to the extent authorized
under the Constitution and the laws of the State of Texas, hold SPONSOR harmless
from liability resulting from the negligent acts or omissions of CANCER CENTER,
its agents or employees pertaining to the activities to be carried out pursuant
to the obligations of this Agreement; provided, however, that CANCER CENTER
shall not hold SPONSOR harmless from claims arising out of the negligence of
SPONSOR, its officers, agents or any person or entity not subject to CANCER
CENTER supervision or control.

         SPONSOR shall indemnify and hold harmless SYSTEM, CANCER CENTER, their
regents, officers, agents and employees from any liability or loss resulting
from judgments or claims against them arising out of the activities to be
carried out pursuant to the obligations of this Agreement or the use by

                                       -3-

<PAGE>   4

SPONSOR of the results of the Research, provided, however, that the following is
excluded from SPONSOR's obligation to indemnify and hold harmless:

                  a.       the negligent failure of CANCER CENTER to comply with
                           any applicable governmental requirements; or

                  b.       the negligence or willful malfeasance by a regent,
                           officer, agent or employee of CANCER CENTER or
                           SYSTEM.

         13. Award. SPONSOR agrees to pay CANCER CENTER a fee of [*]. This fee,
as shown [*] in Exhibit 1, which is attached hereto and is incorporated herein
by reference, for information only, shall be payable [*].

         14. Basic Term. This Agreement shall become effective as of the date
first herein above written and unless earlier terminated as hereinafter
provided, shall continue in force for a period of Eighteen (18) months after the
same.

         15. Default and Termination. In the event that either party to this
Agreement shall be in default of any of its material obligations hereunder and
shall fail to remedy such default within [*] after receipt of written notice
thereof, the party not in default shall have the option of terminating this
Agreement by giving written notice thereof, notwithstanding anything to the
contrary contained in this Agreement. Termination of this Agreement shall not
affect the rights and obligations of the parties which accrued prior to the
effective date of termination. SPONSOR shall pay CANCER CENTER for all
reasonable expenses Incurred or committed to be expanded as of the effective
termination date, subject to the maximum amount as specified in Article 13.

         16. Entire Agreement. The parties acknowledge that this Agreement and
the attached Exhibits hereto represent the sole and entire Agreement between the
parties hereto pertaining to the Research and that such supersedes all prior
Agreements, understandings, negotiations and discussions between the parties
regarding same, whether oral or written. There are no warranties,
representations or other Agreements between the parties in connection with the
subject matter hereof except as specifically set forth herein. No supplement,
amendment, alteration, modification, waiver or termination of this Agreement
shall be binding unless executed in writing by the parties hereto.

         17. Reform of Agreement. If any provision of this Agreement is, or in
doomed invalid, illegal or unenforceable in any United States jurisdiction, such
provision shall be deemed amended to conform to applicable laws so as to be
valid and enforceable; or if it cannot be so amended without materially altering
the Intention of the parties, it shall be stricken, and the remainder of this
Agreement shall remain in full force and affect.

         [*]    Certain information on this page has been omitted and filed
                separately with the Commission. Confidential treatment has been
                requested with respect to the omitted portions.

                                       -4-

<PAGE>   5

         18. Default and Termination. Any notices, statements, payments, or
reports by this Agreement shall be considered given if sent by United States
Certified Mail, postage prepaid and addressed as follows:

         If to CANCER CENTER:

         Michael J. Sent
         Chief Financial officer

         The University of Texas M.D. Anderson Cancer Center 1515 Holcombe Blvd.
         Houston, Texas  77030

         If to SPONSOR

         David Nance
         Managing Partner
         Texas Biomedical Development Partners
         100 Congress Avenue, Suite 200 Austin, Texas  78701

         19. Caption. The captions in this Agreement are for convenience only
and shall not be considered a part of or affect the construction or
interpretation of any provision of this Agreement.

         20. Governing Law. This Agreement shall be governed and interpreted in
accordance with the substantive laws of the State of Texas and with applicable
laws of the United States of America.

                                       -5-

<PAGE>   6

         IN WITNESS WHEREOF, CANCER CENTER and SPONSOR entered into this
Agreement effective as of the date first herein above written and have executed
three (3) originals each of which are of equal dignity.

TEXAS BIOMEDICAL DEVELOPMENT                   THE UNIVERSITY TEXAS
PARTNERS                                       M.D. ANDERSON CANCER CENTER

By:/s/ DAVID NANCE                             By:/s/MICHAEL J. BEST
---------------------------------------           ------------------------------
     David Nance                                   Michael J. Best
     Managing Partner                              Chief Financial Officer

I have read this agreement and
understanding my obligations hereunder:        CONTENT APPROVED:

By:/s/ JACK A. ROTH                            By:/s/ DONNA S. GILBERG
---------------------------------------           ------------------------------
     Jack A. Roth, M.D.                            Donna S. Gilberg, CPA
     Principal Investor                            Manager, Sponsored Agreements

                                               FORM APPROVED:

By:/s/ CHARLES M. BALCH                        By:/s/ MATTHEW E. BURR
---------------------------------------           ------------------------------
     Charles M. Balch, M.D.                        Matthew E. Burr, J.D.
     Head, Division of Surgery                     Legal Services Officer

                                       -6-

<PAGE>   7

                                    EXHIBIT I

                                       [*]

     [*]   Certain information on this page has been omitted and filed
            separately with the Commission. Confidential treatment has been
            requested with respect to the omitted portions.
<PAGE>   8

                                 AMENDMENT NO. 1

                                       TO

                               RESEARCH AGREEMENT

         This Amendment No. 1 to Research Agreement ("AMENDMENT") is made and
entered into as of July 20, 1994 by and between INTRON THERAPEUTICS, INC., a
Delaware Corporation ("SPONSOR") and THE UNIVERSITY OF TEXAS M.D. ANDERSON
CANCER CENTER ("CANCER CENTER"), a component institution of the University of
Texas System ("SYSTEM").

                                    RECITALS

         A. SPONSOR and CANCER CENTER entered into a SPONSORED RESEARCH
AGREEMENT, number SR 93-04, dated as of February 11, 1993 (the "RESEARCH
AGREEMENT").

         B. SPONSOR, CANCER CENTER and the Regents of the University of Texas
System have entered into a PATENT AND TECHNOLOGY LICENSE AGREEMENT dated as of
July 20, 1994 (the "LICENSE AGREEMENT").

         C. CANCER CENTER and SPONSOR wish to extend the term of the RESEARCH
AGREEMENT, acknowledge that the RESEARCH to be conducted thereunder will include
matters beyond the study outline attached to the RESEARCH AGREEMENT as
originally executed, and that SPONSOR will have the option to include within the
LICENSED SUBJECT MATTER under the LICENSE AGREEMENT any intellectual property
that is made in the course of performing under the RESEARCH.

         NOW, THEREFORE, it is hereby agreed as follows:

                  21. DEFINITIONS. Any capitalized terms that are not otherwise
defined herein shall be defined in the RESEARCH AGREEMENT or the LICENSE
AGREEMENT. In addition, for all purposes of the RESEARCH AGREEMENT, the term
"RESEARCH" shall be deemed to include all work of CANCER CENTER personnel in
performing the study described in Exhibit I to RESEARCH AGREEMENT as originally
executed and as modified from time to time, as well as any work that is
performed by Dr. Jack A. Roth or other CANCER CENTER personnel comprising
additional research projects described in Attachment A-n, where n represents the
ordinal number of a particular project.

                  22. Invention and Patents. Section 3 of the RESEARCH AGREEMENT
shall be amended as follows:

                           (a) So much of Section 3(a) of the RESEARCH AGREEMENT
as reads "(i) arises out of work performed pursuant to the obligations of this
AGREEMENT' is hereby amended to read "(i) arises out of the Research;"

<PAGE>   9

                           (b) Paragraph (b) of Section 3 is hereby deleted and
replaced in its entirety with the following:

                  "b.      In the event that an Invention is made, CANCER CENTER
                           shall notify SPONSOR, which notice shall reference
                           this Section 3 and include a description of the
                           Invention in reasonable detail. SPONSOR shall have
                           the option to include all worldwide patent rights
                           with respect to such Invention within the "EXISTING
                           PATENT RIGHTS" under Section 2.3(a) of the LICENSE
                           AGREEMENT,' and to include related information,
                           know-how, biological materials and the like within
                           the TECHNOLOGY RIGHTS under the LICENSE AGREEMENT. To
                           exercise such option with respect to any particular
                           Invention, SPONSOR shall so notify CANCER CENTER
                           within 120 days after receipt of CANCER CENTER's
                           notice thereof as described above. Promptly following
                           such exercise, the parties shall revise Schedule A to
                           the LICENSE AGREEMENT to reflect the additional paten
                           applications so included. CANCER CENTER warrants to
                           SPONSOR that CANCER CENTER has the right to grant to
                           SPONSOR the option and rights contemplated in this
                           Section 3 and that upon exercise of the option
                           described herein with respect to any Invention, all
                           worldwide patent rights therein will be included
                           under the LICENSE AGREEMENT.'

                  23. Term. Section 14 of the RESEARCH AGREEMENT is hereby
amended by adding to the end thereof the following: "Following such initial
Eighteen (18) month period, unless earlier terminated as provided in Section 15,
this Agreement shall continue in full force and effect until terminated by
either parry for any reason on ninety (90) days prior written notice to the
other party."

                  24. Other. Except as expressly provided in this AMENDMENT, all
other terms, conditions and provisions of the RESEARCH AGREEMENT shall continue
in effect as provided therein.

         IN WITNESS WHEREOF, CANCER CENTER and SPONSOR entered into this
AMENDMENT effective as of the date first hereinabove written and have executed
(3) originals each of which are of equal dignity.

                                       -2-

<PAGE>   10

         IN WITNESS WHEREOF, each of the parties has executed this Amendment as
of the date first above written.

TEXAS BIOMEDICAL DEVELOPMENT                        THE UNIVERSITY OF TEXAS
PARTNERS                                            M.D. ANDERSON CANCER CENTER

By:/s/ DAVID NANCE                                  By:/s/ MICHAEL J. BEST
-----------------------------------                    -------------------------
     David Nance                                        Michael J. Best
     Managing Partner                                   Chief Financial Officer

I have read this agreement and
understand my obligations
hereunder:                                          CONTENT APPROVED:

By:/s/ JACK A. ROTH                                 By:/s/ DONNA S. GILBERG
-----------------------------------                    -------------------------
     Jack A. Roth, M.D.                                 Donna S. Gilberg, CPA
     Principal Investor                                 Manager, Sponsored
                                                             Agreements

                                                    FORM APPROVED:

By:/s/ HELMUTH GOEFERT                              By:NOT APPLICABLE
-----------------------------------                    -------------------------
     Helmuth Goefert, M.D.                              Matthew E. Burr, J.D.
     Head, Division of                                  Legal Services Officer
     Surgery and Anesthesiology
     (Ad interim)

                                       -3-

<PAGE>   11

                                 AMENDMENT NO. 2

                                       TO

                          SPONSORED RESEARCH AGREEMENT

STATE OF TEXAS
COUNTY OF HARRIS

         AMENDMENT, effective this lst day of January, 1995, between THE
UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER (hereinafter referred to as
"CANCER CENTER"), a component of THE UNIVERSITY OF TEXAS SYSTEM (hereinafter
referred to as "SYSTEM") located at Houston, Texas, and INTROGEN THERAPEUTICS,
formerly Intron Therapeutics, Inc. ((hereinafter referred to as "SPONSOR"), of
the Sponsored Research Agreement made by these parties and dated the 11th day of
February, 1993 and amended the 20th day of July, 199_, regarding research on the
evaluation and study of the "Development of Therapeutic Treatrnent and
Prevention of Lung Cancer".

         1.       CANCER CENTER and SPONSOR agree that the period of work
                  identified the original Sponsored Research Agreement shall be
                  extended to the latter of February 29, 1996 or the completion
                  of the project.

         2.       CANCER CENTER and SPONSOR agree that the work to be done
                  during this extended work period will be performed according
                  to the procedures described in the revised workscope, the
                  title of which is "Development of Gene Therapeutic Treatment
                  and Prevention for Cancer", a copy of which is attached hereto
                  as Exhibit I and incorporated herein by reference. The
                  workscope has been amended and approved in accordance with
                  institutional policy. The sponsored research agreement may be
                  extended by the Sponsor upon notification to CANCER CENTER and
                  Investigator to provide CANCER CENTER and Investigator with
                  the funds needed to complete the research provided the
                  research is within the workscope as herein described.

         3.       CANCER CENTER and SPONSOR agree that the specific additional
                  costs associated with this work shall be [*].

         4.       CANCER CENTER acknowledges that [*].

         OTHERWISE, the terms and provisions of the original Agreement executed
on the 11th of February, 1993 and amended on the 20th day of July, 1994 by and
between the parties shall in full force and effect, provided, however, that in
the event of a conflict in the terms and conditions between this Amendment No. 2
and the Sponsored Research Agreement, the terms and conditions of this Amendment
shall prevail.

         [*]    Certain information on this page has been omitted and filed
                separately with the Commission. Confidential treatment has been
                requested with respect to the omitted portions.
<PAGE>   12

         IN WITNESS WHEREOF, the parties have executed two (2) original
counterparts of this Amendment No. 2, each of which are of equal dignity and
effective a of the date first hereinabove written.

SPONSOR                                THE UNIVERSITY OF TEXAS SYSTEM
                                       M.D. ANDERSON CANCER CENTER

BY:/s/ DAVID NANCE                     BY:/s/ MICHAEL J. BEST
-----------------------------------       --------------------------------------
       David Nance                              Michael J. Best
       President                                Chief Financial Officer
       Introgen Therapeutics, Inc.

                                      I have read this amendment and understand
                                      my obligations hereunder:

                                       BY:/s/ JACK A. ROTH
                                          --------------------------------------
                                                Jack A. Roth, M.D.
                                                Principal Investigator

                                       BY:/s/ HELMUTH GOEPFERT
                                          --------------------------------------
                                                Helmuth Goepfert, M.D.
                                                Ad Interim Head, Div. of Surgery

                                       CONTENT APPROVED:

                                       BY:/s/ DONNA S. GILBERG
                                          --------------------------------------
                                                Donna S. Gilberg, CPA
                                                Manager, Sponsored Programs

Payment Mailing Address:

The University of Texas
M.D. Anderson Cancer Center
Attention:  Manager, Sponsored Programs
P.O. Box 297402
Houston, Texas 77297

Tax ID:  74-6001118-A1

                                       -2-

<PAGE>   13

                                    EXHIBIT I

                                       [*]

     [*]   Certain information on this page has been omitted and filed
            separately with the Commission. Confidential treatment has been
            requested with respect to the omitted portions.
<PAGE>   14

                                 AMENDMENT NO. 3

                                       TO

                          SPONSORED RESEARCH AGREEMENT

         AMENDMENT, effective this 31st day of December, 1995, between THE
UNIVERSITY OF TEXAS M.D. ANDERSON CANCER CENTER (hereinafter referred to as
"CANCER CENTER"), a component of THE UNIVERSITY OF TEXAS SYSTEM (hereinafter
referred to as "SYSTEM") located at Houston, Texas, and INTROGEN THERAPEUTICS
(hereinafter referred to as "SPONSOR"), of the Sponsored Research Agreement made
by these parties and dated the 11th day of February, 1993 and subsequently
amended, regarding research on the evaluation and study of the "Development of
Therapeutic Treatment and Prevention of Lung Cancer".

         1.       CANCER CENTER and SPONSOR agree that the period of work
                  identified in the Original Sponsored Research Agreement shall
                  be extended to December 31, 1996.

         2.       CANCER CENTER and SPONSOR agree that the work to be done
                  during this extended work period will be performed according
                  to the procedures described in the revised workscope, the
                  title of which is "Development of Gene Therapeutic Treatment
                  and Prevention for Cancer", a copy of which is attached hereto
                  as Exhibit I and incorporated herein by reference. The
                  workscope has been amended and approved in accordance with
                  institutional Policy.

         3.       CANCER CENTER and SPONSOR agree that the specific additional
                  costs associated with this work shall be [*].

         4.       CANCER CENTER and SPONSOR agree that the fee of [*].

         5.       Access to Information. All results of and information arising
                  from the Research shall be made available and accessible to
                  SPONSOR by CANCER CENTER. SPONSOR shall have the right to
                  obtain copies or duplicates of such results and information on
                  a timely basis, in either written or electronic form, upon
                  SPONSOR giving CANCER CENTER reasonable notice of SPONSOR"s
                  desire to obtain such results and information.

         OTHERWISE, the terms and provisions of the original Agreement executed
on the 11th day of February, 1993 and subsequently amended by and between the
parties hereto shall remain in full force and effect, provided, however, that in
the event of a conflict in the terms and conditions between this Amendment No. 3
and the Sponsored Research Agreement the terms and conditions of this Amendment
shall prevail.

<PAGE>   15

         IN WITNESS WHEREOF, the parties have executed two (2) original
counterparts of this Amendment No. 3, each of which are of equal dignity and
effective as of the date first hereinabove written.

INTROGEN THERAPEUTICS, INC.           THE UNIVERSITY OF TEXAS
                                      M.D. ANDERSON CANCER CENTER

BY:/s/ DAVID NANCE                    BY:/s/ MICHAEL J. BEST
   -------------------------------       ---------------------------------
       David Nance                             Michael J. Best
       President                               Chief Financial Officer
       Introgen Therapeutics, Inc.

                                      I have read this
                                      amendment and
                                      understand my
                                      obligations hereunder:

                                       BY:/s/ JACK A. ROTH
                                          ---------------------------------
                                                Jack A. Roth, M.D.
                                                Principal Investigator

                                       BY:/s/ HELMUTH GOEPFERT
                                          ---------------------------------
                                                Helmuth Goepfert, M.D.
                                                Ad Interim Head, Div. of Surgery

PAYMENT MAILING ADDRESS:
         The University of Texas
         M.D. Anderson Cancer Center
         Atten: Manager, Sponsored Programs
         P.O. Box 297402
         Houston, Texas 77297
         Tax ID: 74-6001118-Al

                                       -2-

<PAGE>   16

                                    EXHIBIT I

                                       [*]

     [*]   Certain information on this page has been omitted and filed
            separately with the Commission. Confidential treatment has been
            requested with respect to the omitted portions.

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