Document:

EX-10.34

 Exhibit 10.34 
 *** Text Omitted and Filed Separately 
 Confidential Treatment Requested

 Under 17 C.F.R. §§ 200.80(b)(4) 
 and 203.406 
 DEVELOPMENT AGREEMENT 

This Development Agreement (“Development Agreement”) is entered into on April 15th, 2010 (“EffectiveDate”) by and between Cargill,
Incorporated through its Bio Technology Development Center, having its principal place of business at 15407 McGinty Road West, Wayzata, Minnesota 55391 USA (“Cargill”) and Bioamber S.A.S., having a place of business at Route de Bazancourt,
F-51110, Pomacle France (“Bioamber”). Bioamber and Cargill shall be referred to individually as “Party” and collectively as “Parties”, as required by text. 

Background 
  

	 	A.	Cargill has developed a yeast strain designated CB1 (“CB1”) for fermenting dextrose and/or mixed sugar streams and related research tools for modifying
CB1,which are protected by Licensed Patents (as defined in Section 2.5 below). 

  

	 	B.	Bioamber desires to engage Cargill to further develop or modify CB1 with the goal of fermenting dextrose and/or mixed sugar streams to produce succinic acid and salts
thereof. 

  

	 	C.	The Parties desire to grant each other certain rights to use the further developed or modified CB1 as well as other technology that is developed in the course of the
work as provided in this Development Agreement for research purposes only. 

 Cargill and Bioamber mutually agree as follows:

  

	1.	Scope of Work Plan 

  

	1.1	Cargill agrees to perform the services to develop or modify CB1 to produce succinic acid and salts thereof using dextrose (defined as glucose) and/or sucrose as the
fermentation feedstock (“Work Plan”). The Work Plan is more fully described in Exhibit A, which is hereby incorporated by reference into this Development Agreement. CB1 that has been further developed or modified (or the like) under the
Work Plan shall be referred to as “Modified CB1”. Any changes to the Work Plan must be in writing and signed by both Cargill and Bioamber and may be subject to incremental fees depending on resource requirements. 

 

	1.2	In agreeing to perform the Work Plan, Cargill represents and warrants that: 

 

	 	1.2.1	Cargill has the capability, experience, and means necessary to perform the Work Plan, and the Work Plan will be performed using personnel, equipment, and material
qualified and suitable to perform the Work Plan requested; 

  
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	 	1.2.2	Cargill will provide properly trained and informed personnel, and Cargill will be solely responsible for the negligent acts, errors and omissions of its employees,
subcontractors, and agents and for any other person performing services under this Development Agreement at the direct request of Cargill; 

  

	 	1.2.3	Cargill will perform the Work Plan in a workmanlike manner with reasonable skill and care ordinarily exercised by members of the profession practicing under similar
conditions and in accordance with accepted industry practices and professional guidelines; 

  

	 	1.2.4	Subject to Section 13.1, Cargill has in effect and will maintain in effect all permits, licenses and other authorizations necessary to perform the Work Plan; and

  

	 	1.2.5	No other party has rights to its services as described in the Work Plan, and that a work assignment from any third party shall not be accepted, or work by Cargill
aloneshall not be conducted, to develop CB1 or other microorganisms that will be used to (a) directly produce succinic acid and salts thereof, or (b) indirectly produce succinic acid and salts thereof (for example, Cargill may develop microorganisms
to produce precursors of succinic acid, such as fumaric acid and malic acid, so long as such precursors are not converted to succinic acid, such as by chemical modification), for the Term (as defined in Section 10.1) of this Development
Agreement. For purposes of clarity, and as examples, Cargill may sell dextrose as fermentation feedstock to third parties, who may use such dextrose to produce succinic acid; also, Cargill may modify starches to make succinic acid starch
derivatives. 

  

	2.	Fees and Milestones  

  

	2.1	Bioamber shall pay Cargill [***] U.S. Dollars ($[***]) within thirty (30) days of the execution of this Development Agreement. 

 

	2.2	In addition to the payment in Section 2.1, Bioamber shall pay Cargill a total of [***] U.S. Dollars ($[***] to perform the Work Plan, and Cargill will make
available up to [***] per year to perform the work as outlined in the Work Plan. Such total is subject to change based on an annual review of the needs and requirements of the Work Plan. The actual number of FTEs assigned at any given time will be a
function of the Work Plan and will be subject to agreement amongst the Parties. In addition, Bioamber will pay for reasonable expenses incurred by Cargill, including travel. Cargill shall cover ordinary and customary [***]. Cargill shall submit to
Bioamber a monthly invoice for costs owed by Bioamber, accompanied by a report summarizing Cargill’s activities in relation to actual hours worked and expenses incurred. Bioamber will pay Cargill’s costs within thirty (30) days of
receipt of invoice and supporting documentation. Bioamber shall have the right to audit Cargill time sheets from time to time. Such audit shall occur once per year during reasonable business hours by an independent third party agreed to by both
parties, who shall be under obligations of confidentiality. 

  
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	2.3	Bioamber shall also pay Cargill within thirty (30) days of achieving each of the milestones summarized below and more fully described in the Work Plan found in
Exhibit A. For purposes of clarity, payment is triggered [***]. Further, each of the Milestones and Target Dates may be changed according to the needs of the Work Plan and upon written agreement by the parties. 

 

					
	 Milestone
	  	 Target Date
	  	 Payment

	 Milestone 1: [***]
	  	12 months after Effective Date	  	US $[***]
	 Milestone 2: [***]
	  	[***] after Effective Date	  	US $[***]
	 Milestone 3: CB1 Strain Optimization
	  	42 months after Effective Date	  	US $[***]

  

	2.4	Missed Milestones. 

  

	 	2.4.1	In the event Cargill does not achieve a given Milestone provided in Section 2.3 by the Target Date listed in Section 2.3 or modified Milestone and modified
Target Date as agreed to by the Parties, and subsequently achieves such milestone as per the criteria described in Exhibit A, [***] The Target Date for subsequent Milestones will be adjusted to reflect the date on which the Milestone was actually
achieved. If a subsequent Milestone is achieved by the original Target Date listed in Section 2.3, Bioamber will pay Cargill [***] For purposes of clarity and as examples, if Milestones 1 and 2 were not delivered by the Target Dates, but
Milestone 3 is delivered by or before the Target Date, then the total payments due to Cargill at that time would be [***]. 

  

	 	2.4.2	In the event Cargill does not achieve a given Milestone provided in Section 2.3 by the Target Date listed in Section 2.3 or modified Milestone and modified
Target Date as agreed to by the Parties, and Bioamber decides to commercialize Modified CB1, any outstanding milestone payments shall immediately become due such that the total payment due Cargill under this Development Agreement equals [***] U.S.
Dollars (US $[***]). 

  
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	 	2.4.3	Provided that Cargill has respected its undertakings set out in Section 1.2 of this Development Agreement, no other damages shall accrue to Cargill for not
achieving a given Milestone other than provided in Sections 2.4.1, 2.4.2, and 2.5. 

  

	2.5	Option to Research License. In the event Cargill (i) is unable to achieve a given milestone described in Section 2.3 by the Target Date, or
(ii) terminates this Agreement pursuant to Section 10.2, Bioamber shall have the option to obtain a license during the term of this Development Agreement to the patent applications and patents listed in Exhibit B (including any
continuations, continued prosecutions, continuations-in-part, reissues, reexaminations, divisions or substitutions thereof) (collectively “Licensed Patents”), the tool kit listed in Exhibit C (“Licensed Tool Kit”),and Cargill
Improvements if any (as defined in Section 5.2 below), for research use only and for additional monetary consideration (“Research License”). [***], the Research License shall be offered to Bioamber at [***]. Such research use shall be
for the development and optimization of CB1 for the production of succinic acid and salts thereof using dextrose or sucrose as the fermentation feedstock. The Research License shall be provided to Bioamber only, with no rights to sublicense and with
no “have made” rights. Notwithstanding the preceding, Bioamber will be permitted to outsource development work as outlined in the Work Plan and according to the Research License to third parties that have been approved by Cargill, and such
approval shall not be unreasonably withheld. In considering whether or not to outsource such development work to third parties, the Parties recognize that it is in their mutual interest to protect CB1, Modified CB1, Cargill Confidential Information
(as defined in Section 4.1), and Know-How and Licensed Patents (as those terms are defined under the Commercial License Agreement) and, therefore, the Parties shall undertake joint evaluations of third parties who have been identified by
Bioamber to perform such development work, including, for example and not by limitation, a risk assessment of the geography in which such development work will occur, and whether or not such third parties have similar guiding principles as Cargill
(a copy of Cargill’s Guiding Principles and Compliance Policy on Intellectual Property is attached as Exhibit F). Such development work shall not be conducted by such third parties in circumstances where Cargill’s intellectual property is
at an unacceptable risk as determined by Cargill based on the joint evaluations of such third parties.The terms and conditions of such Research License shall be negotiated between the Parties and shall include the terms described in this
Section 2.5 and terms addressing ownership and rights to use of any intellectual property developed. Further, this Development Agreement shall serve as the framework for the Research License. 

 

	2.6	Technology Transfer. In the event Milestone 3 is achieved, Cargill will [***]. 

  
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	2.7	Scale-Up. Following the successful technology transfer, upon request by Bioamber and subject to [***]. Cargill shall invoice Bioamber [***] U.S. Dollars
(US$[***]) per man-day provided, not inclusive of taxes or other governmental fees, and further adjusted for inflation at the time it goes into effect. Cargill shall [***]. 

 

	3.	Alternative Feedstock. Bioamber also desires the right to further develop CB1 to utilize cellulosic biomass as the fermentation feedstock. Cargill hereby grants
Bioamber the option to modify or convert the Work Plan to include the development or modification of CB1 capable of fermenting such cellulosic feedstock (“Modified Work Plan”). If such option is exercised, (a) the terms and conditions
of this Development Agreement shall apply to the Modified Work Plan except (i) new, additional up-front and milestone payments shall apply as provided below, and (ii) any development work performed under the Modified Work Plan will be
[***]; and (b) the commercial license attached as Exhibit D shall be expanded to include the resulting strain developed out of the Modified Work Plan with no additional change in the financial terms. Additionally, the additional up-front fee
[***]. 

  

					
	 Milestone using Alternative Feedstock
	  	Target Date	 	 Payment

	 Up-front Payment
	  	[***]	 	US $[***]
	 Milestone 1: [***]
	  	[***]	 	US $[***]
	 Milestone 2: [***]
	  	[***]	 	US $[***]
	 Milestone 3: [***]
	  	[***]	 	US $[***]

  

	4.	Confidentiality. To carry out the Work Plan, Cargill may receive from, and provide to, Bioamber certain Confidential Information, as defined below. Such
Confidential Information will be disclosed by one Party (the “Disclosing Party”) to the other Party (the “Receiving Party”) on the following terms and conditions: 

 

	4.1	“Confidential Information” means all business, technical, and financial information related to the Work Plan, the terms and discussions relating to the Term
Sheet executed by the parties on December 3, 2009 and December 4, 2009, and to any aspect of the business of each Party that is material to the Work Plan, including, without limitation, Licensed Tool Kit, products, product compositions,
raw materials, specifications, formulae, equipment, business plans and strategies, customer lists, supplier lists, know-how, samples, drawings, pricing informationand other financial information, inventions, ideas, research information, packaging,
manufacturing processes, and other information, or its potential use, that is owned by or in possession of either Party. For purposes of clarity, the parties shall not disclose to each other any Confidential Information that is not material to the
Work Plan, such as, by way of example and without limitation, processes and other information relating to post-fermentation activities. Confidential Information shall not include information that: (a) is in the public domain prior to disclosure
by Disclosing Party; (b) becomes part of the public domain, by publication or otherwise, through no unauthorized act or omission by the Receiving Party; (c) is lawfully in the Receiving Party’s possession prior to disclosure by the
Disclosing Party; or (d) is independently developed by an employee(s) of the Receiving Party with no access to the disclosed Confidential Information. 

  
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	4.2	The Receiving Party agrees to take and maintain proper and appropriate steps to protect Confidential Information of the Disclosing Party. The Receiving Party agrees to
disclose the Confidential Information of the Disclosing Party only to employees or agents of the Receiving Party who are directly involved with the Work Plan contemplated by this Development Agreement, and even then only to such extent as is
necessary and essential to perform the Work Plan. The Receiving Party agrees to inform such employees and agents of the confidential nature of the information disclosed hereunder and to cause all such employees and agents to abide by the terms of
this Development Agreement. 

  

	4.3	The Receiving Party shall not disclose the Disclosing Party’s Confidential Information to any unauthorized party without the Disclosing Party’s prior express
written consent or unless required by court order or order of a similar governmental entity. If a Party is required by court order or order of a similar governmental entity to disclose the other’s Confidential Information, they shall give the
other Party prompt notice of such requirement so that an appropriate protective order or other relief may be sought. 

  

	4.4	The Receiving Party will use Confidential Information only in connection with the Work Plan. Both Parties have reserved all rights to their respective Confidential
Information not expressly granted herein. All documents and/or tangible materials containing or comprising Confidential Information of the Disclosing Party will remain the property of the Disclosing Party. Upon the request of the Disclosing Party,
the Receiving Party will destroy all Confidential Information of the Disclosing Party and any documents prepared by the Receiving Party using Confidential Information of the Disclosing Party and the Receiving Party agrees to provide confirmation of
such destruction in writing. The Receiving Party may, however, keep one copy of any such document in the files of its legal department or outside counsel for record purposes only. 

 

	4.5	Notwithstanding any other provision of this Development Agreement, each Receiving Party acknowledges that a breach of confidentiality and use as provided in this
Section may result in irreparable harm and damages to the Disclosing Party in an amount difficult to ascertain and that cannot be adequately compensated by a monetary award. Accordingly, in addition to any other relief to which the Disclosing Party
may be entitled at law or in equity, the Disclosing Party shall be entitled to seek a temporary and/or permanent injunctive relief from any breach or threatened breach by the Receiving Party. 

  
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	4.6	The obligations imposed by this section, including but not limited to non-disclosure and non-use, however, will endure so long as the Confidential Information of the
Disclosing Party does not become part of the public domain. 

  

	4.7	The existence of and the terms of this Development Agreement, including its Exhibits, are confidential and are not to be disclosed without the prior written approval of
Cargill. 

  

	4.8	Neither Party may make any public announcement concerning this Development Agreement, its subject matter, and the activities and actions it contemplates without the
other Party’s express written consent. 

  

	4.9	This Section 4 supercedes and replaces the Mutual Confidentiality Agreement between the Parties, which was effective July 17, 2009. All Confidential
Information that was subject to that Mutual Confidentiality Agreement is hereby made subject to the terms and conditions of this Section 4. 

  

	5.	Intellectual Property 

  

	5.1	Each party shall retain ownership of all intellectual property that it owned prior to the Effective Date. 

 

	5.2	Improvements. Any invention or discovery relating to the Work Plan, in whole or in part, that is conceived during the term of this Development Agreement shall be
an “Improvement”. The scope for Improvements will be [***]. Bioamber will own any Improvement [***], and such Improvement shall be designated “Bioamber Improvements”. Cargill will own any Improvement in all fields other than the
field of succinic acid and salts thereof, subject to the rights provided in Section 5.2.1 below, and such Improvement shall be designated “Cargill Improvements”. In the event [***], and such Improvement shall be designated “Joint
Improvements”. [***] 

  

	 	5.2.1	Cargill hereby grants Bioamber, and Bioamber hereby accepts, an [***] license to Cargill Improvements and Joint Improvements for use in [***] during the term of this
Development Agreement with a reservation of right for Cargill to practice such Cargill Improvements and Joint Improvements for use in [***] during the term of this Development Agreement. Such use shall be for research purposes only with no rights to
sublicense and with no “have made” rights. Cargill shall also grant a commercial license to Bioamber for Cargill Improvements and Joint Improvements under the terms and conditions of Exhibit D. 

  
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	 	5.2.2	Bioamber hereby grants Cargill, and Cargill hereby accepts, an [***] license with an unlimited right to sublicense under and to Bioamber Improvements for use outside
the Field during the term of this Development Agreement. Such use shall be for research purposes only. 

  

	 	5.2.3	Cargill shall have the first option to prepare, file, prosecute, and maintain patent applications and issued/granted patents on [***], which option may be waived in
whole or in part. [***] bear all costs incurred in connection with such preparation, filing, prosecution, and maintenance of U.S. and foreign application(s) and issued/granted patents directed to [***]. Cargill shall provide Bioamber a copy of any
proposed patent application covering [***] in advance of the submission of the proposed patent application to any patent office. [***] If [***] waives its option, [***] shall have the option to prepare, file, prosecute, and maintain patent
applications and issued patents on [***]. Cargill shall provide, when requested by Bioamber, all information in its possession, or true copies thereof, pertaining to [***] which may be necessary or useful in the preparation, filing, and prosecution
of patent applications covering the [***]. Such information shall be treated as Confidential Information. 

  

	 	5.2.4	If Cargill waives its option to prepare and prosecute a patent application in accordance with Section 5.2.3 and elects not to file such a patent application or
elects to allow any such patent application or issued/granted patent to become abandoned or lapse, Cargill shall give Bioamber notice of such election promptly and at least two (2) months prior to the first date that action must be taken to
avoid such abandonment or lapse. Bioamber shall have the right to take over at its sole expense the filing, prosecution or maintenance of any such patent application and Bioamber shall keep Cargill informed of Bioamber’s filing, prosecution,
and maintenance activities. All out-of-pocket expenses of Cargill shall be reimbursed by Bioamber. Bioamber shall have no liability to Cargill for Bioamber’s acts or failure to act with respect to such patent application or issued/granted
patent. 

  

	 	5.2.5	Cargill shall have the sole power to bring and/or settle suits for infringement of any and all patent applications and/or patents on Improvements, regardless of
ownership; provided, however, if required by law, Cargill shall join Bioamber, and Bioamber shall be joined, in such suits. Cargill shall control any such suits and shall bear all expenses related to any such suits. Bioamber shall provide any
assistance reasonably requested in prosecuting and enforcing any and all patent applications and/or patents on Improvements. In the event Cargill elects not to initiate and prosecute suits for infringement of any patent application/and or patent
onImprovement within the Field, then with sixty (60) days prior written notice to Cargill, Bioamber shall be entitled to initiate and prosecute such suits. For purposes of clarity, within such sixty (60) day period, Cargill shall be
entitled to initiate and prosecute such suits. 

  
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	 	5.2.6	Cargill shall have the sole power to settle suits for infringement of the Licensed Patents. Cargill will in good faith consider enforcement requests from Bioamber.

  

	 	5.2.7	Improvements are to be considered Confidential Information of the owning Party subject to the terms and conditions of Section 4, provided that the Party authorized
hereunder to file and prosecute patent applications for an Improvement may make disclosure of that Improvement to outside patent counsel and to relevant patent offices as reasonably necessary for filing and prosecution of a patent application.

  

	5.3	In consideration of the ownership rights granted to Bioamber under this Section 5, and the licenses granted to Bioamber under this Section 5 and the
Commercial License attached as Exhibit D, Bioamber agrees to the payment terms and its other obligations contained in the attached Commercial License. 

  

	6.	[***] Patents. [***] is the owner of several patents relating to the [***] (“[***] Patents”). Prior to transferring CB1 or any other yeast strain to
Bioamber, Bioamber shall provide to Cargill a letter from [***] stating that Bioamber has a license to the [***] Patents (“Bioamber-[***] License”). Upon receipt of such letter, Cargill will transfer CB1 to Bioamber for
Bioamber’s use of the strain commensurate with and in accordance with the Bioamber-[***] License. Cargill shall have no liability to Bioamber for Bioamber’s acts or failure to act with respect to the [***] Patents.

  

	7.	Warranties. Except as provided in Section 1.2 of this Development Agreement, Cargill makes no representations or warranties, express or implied, with
respect to the services provided under this Development Agreement and with respect to the subject matter of this Development Agreement. The services are provided “as is” and Bioamber acknowledges that it bears all responsibility and
accountability for evaluating, approving, and implementing any of results resulting from this Development Agreement. 

  

	8.	Indemnification. Bioamber and Cargill agree to waive any and all claims against each other for consequential, punitive, incidental, special, or other forms of
“exemplary” losses whether arising in contract, warranty, tort (including negligence), strict liability, or otherwise, including any losses relating to lost use, lost profits, lost business, damage to reputation, or lost or diminished
financing unless such claims are based on a Party’s gross negligence or willful misconduct. 

  

	9.	Notices. All notices or other communication must be in writing and delivered by (a) personal delivery, (b) reputable overnight delivery service, or
(c) facsimile or e-mail, confirmed under clause (a) or clause (b), and addressed in each case as set forth below: 

  
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	If to Cargill:	  	If to Bioamber:
		
	Cargill, Incorporated	  	Bioamber S.A.S.
	[***]	  	1250 Rene-Levesque West
		  	Suite 4110
		  	 Montreal, Quebec
 Canada H3B
4W8

		  	Fax: 514-844-1414
		  	Attention: [***]
		
	 With copy to:
 Cargill,
Incorporated
 [***]
	  	 With copy to:
 Boivin
Desbiens Senécal, g.p.
 [***]

  

	10.	Term and Termination. 

  

	10.1	This Development Agreement will begin on the Effective Date and continue for [***] unless earlier terminated pursuant to Section 10.2, or unless the parties extend
the term by mutual written Development Agreement (“Term”). 

  

	10.2	Either Party may terminate this Development Agreement by giving written notice to the other Party, (a)in the event the other Party’s bankruptcy, insolvency, or the
filing of a petition therefore; and (b) the other Party materially defaults in the performance of its obligations hereunder. This Development Agreement shall also terminate upon mutual written agreement by the Parties. Further, in the event
there is a dispute as to whether or not Cargill has missed a certain Milestone, then the Target Date for that Milestone shall be tolled until the Parties, acting in good faith, have settled such dispute in writing between themselves or through an
independent expert. 

  

	11.	Independent Contractor. Nothing in this Development Agreement is to be construed to deem the relationship between the parties to be one of master/servant,
principal/agent, or employer/employee. To the contrary, the relationship of Cargill to Bioamber is that of independent contractor, and Cargill will have no authority to (i) make any binding decision for, or on behalf of, Bioamber or
(ii) commit Bioamber to any contract, obligation, debt, or other liability. None of Cargill’s employees will be deemed to be employees of Bioamber. 

 

	12.	Publicity. Any public statements related to work performed under this Development Agreement, including public statements related to the existence of this
Development Agreement itself, will only be made after the prior written consent of both Parties concerning timing, content, and audience. 

  
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	13.	Miscellaneous. 

  

	13.1	Third Party Patents. In addition to the [***] Patents as described more fully in Section 6, the CB1 Team of the Bio Technology Development Center of Cargill
represents that, to the best of its knowledge as of the Effective Date, the patents and patent applications of third parties that could impact the Work Plan and the commercialization thereof are provided in Exhibit E (“Third Party
Patents”). Cargill shall have no liability to Bioamber for Bioamber’s acts or failure to act with respect to such Third Party Patents. The Parties shall meet regularly throughout the Term of this Development Agreement to determine whether
or not licenses to Third Party Patents are needed to perform or continue to perform the Work Plan and the next steps if such licenses are needed. 

  

	13.2	Governing Law. This Development Agreement shall be governed by and construed in accordance with the laws of the State of Minnesota, United States of America,
disregarding its conflicts of law rules. 

  

	13.3	Assignment. Neither Party shall assign this Development Agreement or the obligations contained herein without the express written consent of the other Party.

  

	13.4	Waiver. The failure of either Party to insist in any one or more instances upon performance of any terms or conditions of this Development Agreement, is not to
be construed as a waiver of future performance of any such term, covenant, or condition, but the obligations of either Party with respect thereto will continue in full force and effect. No waiver will be effective unless in writing and signed by the
waiving Party. 

  

	13.5	Amendment. No amendment, modification, or waiver of the terms of this Development Agreement shall be binding unless placed in writing and duly executed by the
Parties’ authorized representatives. 

  

	13.6	Severability. All provisions contained herein are severable, and in the event any of them is held to be invalid by any competent court or arbitrator, this
Development Agreement is to be interpreted as if such invalid provision were not contained herein. 

  

	13.7	Survivability. Sections 4 (Confidentiality), 5 (Intellectual Property), 6 ([***] Patents), 7 (Warranties), 8 (Indemnification), 13.2 (Governing Law), and 13.7
(Survivability) will survive the expiration or earlier termination of this Development Agreement. 

  

	13.8	Entire Agreement. This Development Agreement supersedes all previous understandings between Cargill and Bioamber concerning the subject matter of this
Development Agreement, including but not limited to the Term Sheet executed by the Parties on December 3, 2009 and December 4, 2009, and the Mutual Confidentiality Agreement between the Parties which was effective July 17, 2009, and,
together with its attachments, including the Commercial License Agreement attached hereto as Exhibit D executed concurrently with this Development Agreement, contains the entire agreement between the parties with respect to the subject matter
hereof, and may not be amended, modified, or supplemented except in writing and signed by both Parties specifically referring to this Development Agreement and the Commercial License Agreement. 

 

	13.9	Bioamber Non-Compete Commitment. Bioamber will not itself or with or through third parties [***] production of succinic acid or salts thereof, except for the
development activities under the terms and conditions of this Development Agreement. This obligation endures for the Term of this Development Agreement. Notwithstanding the above, Bioamber shall be permitted to [***]. The purpose of such evaluations
shall be to identify and eventually secure alternative technologies, in the event that the CB1 development program is not successful. [***], including but not limited to the genetic modification or the optimization of fermentation conditions, [***].
This restriction shall apply to [***] developed in-house, licensed-in, or under development at a third party lab that is funded by Bioamber or to which Bioamber has secured a future right or right of first refusal through direct payment, in kind
contribution, grant, gift, differed payment or commitment to a future payment. 

  
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 The Parties, through their authorized representatives, hereby agree to the terms and conditions of this
Development Agreement. 
  

					
	 CARGILL, INCORPORATED
 Bio
Technology Development Center
	 		 	BIOAMBER S.A.S.
			
	/s/ Jack Staboch	 		 	/s/ Jean-François Huc
	Signature	 		 	Signature
			
	 VP BioTDC
	 		 	Director General
	Title	 		 	Title
			
	4/16/10	 		 	April 15, 2010
	Date	 		 	Date

  
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 Exhibit A 
 Work Plan 
 Milestones 

[***] 
 MILESTONE 1 

[***] 
 MILESTONE 2 

[***] 
 MILESTONE 3 

[***] 

  
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 Exhibit B 
 Cargill Patents and Patent Applications 
 [*** 4 pages omitted.] 

  
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 Exhibit C 
 Licensed Tool Kit 
 [***] 

  
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 EXHIBIT D 
 COMMERCIAL LICENSE AGREEMENT 

  
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 EXHIBIT E 
 Third Party Patents relating to the Work Plan 
  

			
	Publication number and title	  	Assignee
	 [***]
	  	

 Third Party Patents relating to Modified Work Plan 

 

			
	Publication number and title	  	Assignee
	 [***]
	  	

  
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 EXHIBIT F 
 Cargill’s Guiding Principles 
  

	 	•	 	 Cargill will comply with the laws of all countries to which it is subject. 

 

	 	•	 	 Cargill will not knowingly assist any third party to violate any law of any country, by creating false documents or by any other means.

  

	 	•	 	 Cargill will not pay or receive bribes or participate in any other unethical, fraudulent, or corrupt practice. 

 

	 	•	 	 Cargill will always honor all business obligations that it undertakes with absolute integrity. 

 

	 	•	 	 Cargill will keep its business records in a manner that accurately reflects the true nature of its business transactions. 

 

	 	•	 	 Cargill managers and supervisors will be responsible that employees, consultants and contract workers under their supervision are familiar with
applicable laws and company policies and comply with them. Further, they will be responsible for preventing, detecting, and reporting any violations of law of Cargill policies. 

 

	 	•	 	 Cargill employees will not become involved in situations that create a conflict of interest between the company and the employee.

  

	 	•	 	 Every year, all Cargill employees sign an agreement to live these principles. 

Cargill’s Compliance Policy on Intellectual Property 
 [*** 2 pages omitted.] 

  
 Cargill
Confidential 
 - 18 - 
 * Confidential treatment requested 

 AMENDMENT 1 TO DEVELOPMENT AGREEMENT 

This is the First Amendment (“First Amendment”) to the Development Agreement (“Development Agreement”) entered into on April 15,
2010, by and between Cargill, Incorporated through its Bio Technology Development Center, having its principal place of business at 15407 McGinty Road West, Wayzata, Minnesota 55391 USA (“Cargill”) and BioAmber S.A.S., having a place of
business at Route de Bazancourt, F-51110, Pomacle France (“BioAmber”). This First Amendment will be effective as of July 5, 2011, upon the signature of both Cargill and BioAmber. 

Cargill and Bioamber mutually agree as follows: 
  

	1.	Section 2.2 of the Development Agreement is hereby amended to allow Cargill at its sole discretion to apply [***] during the period of July 5, 2011, through
September 30, 2011, to perform the Work Plan in addition to the [***] specified in the unamended Section 2.2. The terms for compensation and expenses for these [***] will be as provided for the original [***] in Section 2.2.

  

	2.	Other than as expressly modified by this First Amendment, all terms and conditions of the Development Agreement continue without modification. 

The Parties, through their authorized representatives, hereby agree to the terms and conditions of this First Amendment. 

 

					
	 CARGILL, INCORPORATED
 Bio
Technology Development Center
	 		 	BIOAMBER S.A.S.
			
	/s/ Jack Staboch	 		 	/s/ Jim Millis
	Signature	 		 	Signature
	VP BioTDC	 		 	CTO
	Title	 		 	Title
	7/14/11	 		 	7/18/11

  
 Cargill
Confidential 
 * Confidential treatment requested 

 AMENDMENTS TO COMMERCIAL LICENSE AGREEMENT AND DEVELOPMENT 

AGREEMENT 
 WHEREAS, Cargill, Incorporated (“Cargill”) and BioAmber S.A.S. (“Bioamber”) entered into a Development Agreement having an Effective Date of April 15th, 2010, as amended on July 5th, 2011 (the “Development Agreement”); 

WHEREAS, Cargill and Bioamber entered into a Commercial License Agreement having an Effective Date of April 15, 2010 (the
“Commercial License”); 
 WHEREAS, Bioamber now desires to amend the Development Agreement to allow Bioamber to fund a
research project being conducted by the [***], which involves the molecular re-engineering of a [***] owned by [***] and the development of a lab scale fermentation design for using the re-engineered [***] to make succinic acid or salts thereof from
a [***] feedstock (the “[***] Project”). The [***] Project will be co-funded by funds available from the [***]; 

WHEREAS, Bioamber further desires to scale-up the production of succinic acid using a [***] available from [***] and to possibly produce
succinic acid or salts using [***] at: (1) Bioamber’s existing demonstration-scale succinic acid production facility located at Pomacle, France; and (2) a succinic acid production facility located at Sarnia, Ontario Canada having a
maximum production capacity of 35,000 metric tons of succinic acid per year (the “Sarnia Plant”). Together these scale-up projects will be referred to as the “Scale-up and Production Project”; 

WHEREAS, Cargill is willing to allow Bioamber to fund the [***] Project and to conduct the Scale-up and Production Project, subject to
the following terms and conditions. Now therefore the Parties agree: 
 Amendment To the Development Agreement 

A. Section 13.9 of the Development Agreement is amended to add the following at the end of the Section: 

“Notwithstanding the above, Bioamber may fund the [***] Project up until the [***] demonstrates the ability to produce succinic acid
(or salts thereof) from [***] at a concentration of [***] grams/liter succinic acid (or salts thereof). Within thirty (30) days of the [***], Bioamber will [***] Project. Further Bioamber will require that any unexpended funds received from Bioamber
be utilized for a project other than the [***] Project. 
 B. New Section 13.10 is added to the Development Agreement as set forth below:

 “13.10 Notwithstanding the provisions of section 13.9, Bioamber may conduct the Scale-up and Production Project, subject
to Bioamber hereby agreeing to convert the demonstration-scale Pomacle France succinic acid production facility and the Sarnia Plant [***] for the production of succinic acid (and/or salts thereof). This conversion will be carried out according to
the provisions of Section 5.9 of the Commercial License, it being understood that all economic obligations of item (iv) above will be relative to the [***] technology, not [***]. In order to enable such conversion, Bioamber will put in place
agreements with the owners/operators of the Sarnia Plant that will enable Bioamber to require such conversion of the Sarnia Plant to [***] for the manufacture of succinic acid as described above.” 

Amendment To the Commercial License 
 A. Section 5.9 of the Commercial License is amended to add the following at the end of the Section: 
 “Bioamber shall use best efforts to obtain regulatory approvals for the use of the CB1 Strain in all countries where Bioamber and/or a Bioamber licensee are using any strain other than the CB1 strain
for the production of succinic acid and/or salts thereof. Additionally, Bioamber shall use best efforts to scale up the CB1 Strain and fermentation protocols utilizing the CB1 Strain.” 
 Nothing in these amendments will reduce Bioamber’s obligations to [***] of Bioamber and Bioamber licensees, according to the provisions of Section 5.9 of the Commercial License. 

  
 * Confidential
treatment requested 

 
			
	CARGILL, INCORPORATED
		
	By:	 	/s/ Pirkko Suominen
		 	 Name: Pirkko Suominen
 Title: Director, Bio Technology Development Center, Minneapolis

	Date:	 	10/19/2011
	
	BIOAMBER, SAS
		
	By:	 	/s/ Jean-François Huc
		 	 Name: Jean-François Huc
 Title: President

	Date:	 	October 15, 2011

  
 * Confidential
treatment requestedEX-10.35

 Exhibit 10.35 
 *** Text Omitted and Filed Separately 
 Confidential Treatment Requested

 Under 17 C.F.R. §§ 200.80(b)(4) 
 and 203.406 
 LICENSE AGREEMENT 

This License Agreement (the “Agreement”), made and effective as of June 28, 2010 (the “Effective Date”), by and between
E. I. du Pont de Nemours and Company, a Delaware corporation having its principal place of business at 1007 Market Street, Wilmington, Delaware 19898 (“DuPont”) and Bioamber S.A.S., a French corporation having its principal place of
business at Route de Bazancourt, F-51110, Pomacle France (“Bioamber”). In this Agreement DuPont and Bioamber shall also be referred to individually as a “Party” and collectively as the “Parties.” 

RECITALS 
 WHEREAS,
DuPont is has certain rights in certain U.S. patents, which patents are licensed to DuPont by [***], pertaining to the hydrogenation of organic acid feedstocks, including but not limited to succinic acid, in a fixed-bed reactor to produce 1,4
butanediol (“BDO”) and tetrahydrofuran (“THF”). 
 WHEREAS, DuPont is the owner of the Licensed Intellectual Property (as
defined below); 
 WHEREAS, Bioamber is in the business of manufacturing succinic acid and derivative products used in a variety of
applications; and 
 WHEREAS, Bioamber desires to obtain a sublicense under the aforementioned patents and a license to the Licensed
Intellectual Property, all to produce BDO and THF from succinic acid according to the terms hereof, and DuPont is willing to grant such sublicense and rights to Bioamber. 
 NOW, THEREFORE, in accordance with the foregoing recitals and the rights and obligations specified herein, and for good and valuable consideration, the receipt of which is hereby recognized, DuPont and
Bioamber agree as follows: 
  

	1.	DEFINITIONS 

 1.1. “Affiliate”
means any corporation, firm, limited liability company, partnership or other entity that directly or indirectly Controls or is Controlled by or is under common Control with a Party to this Agreement, for so long as such Control-based relationship
exists. 
 1.2. “Catalysts” mean those catalysts claimed in the Sublicensed Patents. 

1.3. “Confidential Information” means information disclosed by a Disclosing Party hereunder when such is identified as the confidential
information of the Disclosing Party. Tangible embodiments of information shall be deemed as “identified as confidential information” if clearly labeled as “Confidential” or “Proprietary” or with some other legend or
marking indicating the confidential nature of the information. Information that is disclosed verbally or by other non-tangible disclosure to the Receiving Party shall be deemed as “identified as confidential information” if it is set forth
by the Disclosing Party in a writing clearly labeled “Confidential” or “Proprietary” or with some other legend or marking indicating the confidential nature of the information, and the writing is delivered to the Receiving Party
within fifteen (15) days of said verbal/non-written disclosure. Information disclosed verbally or by other non-written disclosure to the Receiving Party shall be treated as Confidential Information during the fifteen (15) day period
following such disclosure. 

  
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* Confidential treatment requested 

 1.3.1. Information shall not be considered Confidential Information to the extent that any
such information was (a) as of the date of disclosure to the Receiving Party, known to the Receiving Party and such knowledge can be substantiated by reasonable documentation; (b) as of the date of disclosure to the Receiving Party,
disclosed in published literature or generally available to the public; (c) after the date of disclosure to the Receiving Party, disclosed in published literature or generally available to the public, other than by a breach by the Receiving
Party of the obligations of confidentiality and non-use set forth in this Agreement; (d) developed by the Receiving Party independently from, and without exposure to, the information provided by the Disclosing Party; or (e) obtained by the
Receiving Party from a third party without binder of secrecy, provided that such third party had no obligation of confidentiality to the Disclosing Party or any of its Affiliates relating to the Confidential Information. 

1.3.2. Information disclosed hereunder shall not be deemed to be within the exceptions merely set forth in Section 1.3.1 merely
because such information is embraced by more general knowledge in the public domain or in the Receiving Party’s possession. In addition, no combination of features shall be deemed to be within the foregoing exceptions merely because individual
features are in the public domain or in the Receiving Party’s possession, but only if the combination itself and its principles of operation are in the public domain or in the Receiving Party’s possession. 

1.3.3. For the purposes of Sections 1.3 through 1.3.3, inclusive, “information” includes, without limitation, all information
relating to existing and potential inventions (whether or not reduced to practice), discoveries, know-how, technologies, reports, data, results, observations, computer programs, patent applications, hypotheses, research directions, developments,
improvements, drawings, designs, specifications, methodologies, algorithms, formulas, protocols, strategic plans, business plans, business opportunities, draft and/or final regulatory filings, customers, potential customers, suppliers, markets,
contracts, prices, products, personnel, strategies, policies, systems, procedures, information, processes, research, applications, methods of manufacture and any other information relating to the Disclosing Party or any of its Affiliates.

 1.4. “Commercial Field” means the manufacture of Hydrogenation Products and the use, selling or otherwise transferring, offering
for sale, and/or exporting of such Hydrogenation Products. 
 1.5. “Control” means ownership, directly or through one or more
Affiliates, of fifty percent (50%) (or such lesser percentage which is the maximum allowed to be owned by a foreign entity in a particular jurisdiction) or more of the shares of stock entitled to vote for the election of directors in the case
of a corporation, or fifty percent (50%) (or such lesser percentage which is the maximum allowed to be owned by a foreign entity in a particular jurisdiction) or more of the equity interests in the case of any other type of legal entity, or
status as a general partner in any partnership, or any other arrangement whereby a Party controls or has the right to control the board of directors or equivalent governing body of a corporation or other entity. 

1.6. “Delayed Rights Date” [***]. 

  
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 1.7. “Development Period” means the period commencing on the Effective Date and ending on the
earlier of (a) the [***] year anniversary of the Effective Date, and (b) the date on which DuPont receives a written notice from Bioamber indicating that the Development Period has ended and Bioamber’s right of termination
pursuant to Section 6.2 has terminated, provided that in no event shall the Development Period end prior to the Delayed Rights Date. 
 1.8. “Disclosing Party” means a Party disclosing its Confidential Information to a Receiving Party hereunder. 
 1.9. “DuPont Background Technology” means all inventions, know-how, technology, or other information related to the Sublicensed Patents that is owned by DuPont or which DuPont has the
right to license as of the Effective Date. 
 1.10. “DuPont Indemnitees” means DuPont and its directors, officers, agents, employees,
contractors, and representatives; DuPont’s Affiliates and their directors, officers, agents, employees, contractors, and representatives of DuPont’s Affiliates; and the successors, heirs and assigns of any of the foregoing. 

1.11. “Exclusion Period” means the [***] year period commencing on the Effective Date and ending on the [***] year anniversary of
the Effective Date. 
 1.12. “Hydrogenation” means the process of hydrogenating succinic acid as claimed in the Sublicensed Patents.

 1.13. “Hydrogenation Products” means [***] made from Hydrogenation. 

1.14. “Improvements” means all inventions, know-how, technology, or other information discovered or developed by or for Bioamber during the
Term related to the Sublicensed Patents to the extent that such inventions, know-how, technology, or other information is not incorporated in the DuPont Background Technology. 

 

	1.15.	[***] 

 1.16. “Licensed Intellectual
Property” means the information in the Technical Reports and the Technical Know-how. 
 1.17. “Patent Challenge” means a
challenge to the validity, patentability, enforceability and/or non-infringement of any of the Sublicensed Patents or otherwise opposing any of the Sublicensed Patents. 

 

	1.18.	[***] 

 1.19. “Receiving
Party” means a Party receiving Confidential Information from the Disclosing Party hereunder. 
 1.20. “Representatives” means the
directors, officers, employees, agents, contractors, and/or Affiliates of a Receiving Party to whom the Receiving Party needs to disclose Confidential Information in connection with the Parties’ performance under this Agreement. 

1.21. “Research Field” means making research and development quantities of Hydrogenation Products and using such Hydrogenation Products for
one’s own internal research purposes. For the purposes of this Agreement “research and development quantities” includes such amounts as would be used or produced in laboratory scale research projects, but does not include amounts used
or produced in pilot study projects. 
 1.22. “Sublicensed Patents” means the United States patents presently licensed to DuPont by
[***] and listed in Schedule A. 

  
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 1.23. “Technical Know-how” means the information in the responses to any consulting questionnaires
provided pursuant to Section 2.9.1. 
 1.24. “Technical Reports” means the documents listed in Schedule B. 

1.25. “Term” means the period starting on the Effective Date and ending on the [***] anniversary of the Effective Date. 

1.26. “Third Party” means an entity other than DuPont or Bioamber. Third Parties include, without limitation, the Affiliates of the Parties.

  

	2.	SUBLICENSE GRANT 

 2.1. Grant.

 2.1.1. DuPont hereby grants the following rights to Bioamber solely within the Research Field: (a) a non-exclusive,
worldwide sublicense, under the Sublicensed Patents to perform Hydrogenation, and (b) a non-exclusive, worldwide license, under the Licensed Intellectual Property to perform Hydrogenation. The sublicense and license granted in this
Section 2.1.1 shall be effective as of the Effective Date. 
 2.1.2. DuPont hereby grants the following rights to Bioamber
solely within the Commercial Field: (a) a non-exclusive, worldwide sublicense, under the Sublicensed Patents to perform Hydrogenation, and (b) a non-exclusive, worldwide license, under the Licensed Intellectual Property to perform
Hydrogenation. The sublicense and license granted in this Section 2.1.2 shall be effective as of the Delayed Rights Date, provided that on the Delayed Rights Date Bioamber is in compliance with all the terms and conditions of this Agreement.

 2.2. Sublicensing Rights. 
 2.2.1. As of the end of the Development Period, Bioamber shall have the right to sublicense the rights granted pursuant to Section 2.1.1 and/or 2.1.2 to Third Parties, subject to DuPont having
the right to reject any potential sublicensee, and provided that any such Third Party agrees to abide by all the terms of this Agreement as they apply to Bioamber as a rights grantee hereunder. Bioamber shall grant no sublicenses during the
Development Period other than sublicenses of the rights granted pursuant to Section 2.1.1 to allow Third Parties to assist Bioamber with the further development pursuant to Section 2.12.2. 

a. Prior to the granting of any such sublicense, Bioamber will provide DuPont a written notice identifying the potential Third Party that
Bioamber desires to sublicense and the scope of the rights Bioamber desires to sublicense to such Third Party. 
 b. DuPont shall
have thirty (30) days from the receipt of such notice to provide a written notice to Bioamber rejecting such Third Party as a sublicensee. Failure by DuPont to provide such notice to Bioamber within the above-noted thirty (30) day period
shall be deemed as DuPont having waived its right to reject such potential sublicensee to be granted rights of the scope set forth in the notice. 
 c. DuPont agrees to not exercise its right of rejection in a commercially unreasonable manner, and DuPont agrees not to reject a proposed sublicensee

  
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solely on the grounds that it is a competitor of DuPont. The fact that DuPont has rejected or failed to reject any potential sublicensee shall create no obligation on DuPont with respect to its
right of rejection with respect to any other potential sublicensee presented by Bioamber. 
 d. In the event that DuPont fails to
exercise its right of rejection hereunder and, DuPont shall incur no liability for the actions of Bioamber or any sublicensee as a result of DuPont allowing Bioamber to sub-license the rights granted pursuant to Section 2.1.1 and/or 2.1.2 to
any Third Party, and Bioamber hereby indemnifies and hold DuPont harmless in the event of any such claim. 
 2.2.2. Provided that
this Agreement is not terminated pursuant to any of Sections 6.2, 6.3.1, 6.3.2, 6.4, and or 6.5 through 6.5.2, inclusive, DuPont agrees that it shall grant a license granting such Third Party sublicensee the rights granted pursuant to
Section 2.1.1 and/or 2.1.2 to those Third Parties having a valid sublicense to the rights granted pursuant to Section 2.1.1 and/or 2.1.2 on the date this Agreement is so terminated, provided that any such Third Party sublicensee(s)
is not then in default under the terms of the sublicense agreement between the Third Party and Bioamber and further provided that DuPont shall be under no obligation to grant any such license in the event that so doing would violate any law
or legal or governmental regulation. The financial terms of such license between DuPont and the Third Party shall be the same as those set forth in the sublicense agreement then in effect between the Third Party and Bioamber. The license agreement
between DuPont and such Third Party shall obligate such Third Party to immediately pay to DuPont any amount in arrears under the sublicensee agreement between the Third Party and Bioamber and shall obligate such Third Party to abide by all the terms
of this Agreement as they apply to Bioamber as a rights grantee hereunder. DuPont’s obligations under this Section shall not apply to any sublicense granted during the Development Period. Other than the granting of a license as described above,
DuPont shall have no affirmative to take any action that Bioamber may have had in the sublicense agreement between the Third Party and Bioamber, including without limitation the obligation to provide any training, rights to improvements, technical
services, etc.). 
 2.2.3. Bioamber shall promptly notify DuPont of the identity of any Third Party to which it has sub-licensed
the rights granted pursuant to Section 2.1.1 and/or 2.1.2. 
 2.3. License Restrictions and Limitations. 

2.3.1. The Parties each agree that the rights granted pursuant to Section 2.1.1 do not include any rights to use or make the
Catalysts, other than for the performance of Hydrogenation in the Research Field. 
 2.3.2. The Parties each agree that the
rights granted pursuant to this Section 2.1.2 do not include any rights to use, manufacture, offer for sale, sell, or export the Catalysts, other than for the performance of Hydrogenation in the Commercial Field. 

2.3.3. The Parties each agree that Bioamber shall make no use of the Catalysts, other than for the performance of Hydrogenation in the
Research Field or for the performance of Hydrogenation in the Commercial Field, as licensed hereunder 
 2.3.4. The Parties each
agree that the Licensed Intellectual Property contains no information concerning the production or use of [***] or any other downstream products produced from the Hydrogenation Products. The Parties each agree that the

  
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rights granted pursuant to Sections 2.1.1 and/or 2.1.2 do not include any rights to produce [***] or any other downstream products from the Hydrogenation Products. This Section, however,
shall not be construed to restrict Bioamber or its customers from using for any purpose the Hydrogenation Products made or produced pursuant to this Agreement. . 
 2.3.5. The Parties each agree that Bioamber shall make no use of the rights granted pursuant to Sections 2.1.1 and/or 2.1.2 and or the Licensed Intellectual Property to produce or use [***] or any
downstream products produced from the Hydrogenation Products. 
 2.3.6. The Parties each agree that Bioamber shall not make any
use of the Licensed Intellectual Property outside the scope of the rights granted in Sections 2.1.1 and 2.1.2. 
 2.3.7. The
Parties each agree that DuPont has made no representation that the Licensed Intellectual Property contains information concerning the production or use of [***] or any downstream products produced from the Hydrogenation Products or that the
rights granted in Sections 2.1.1 and 2.1.2 will allow Bioamber to make any use of the Licensed Intellectual Property outside the scope of the rights granted in Sections 2.1.1 and 2.1.2 or to produce [***] or any downstream products from the
Hydrogenation Products. 
 2.4. Commercial Benefits. The Parties each agree that the benefits accruing to Bioamber pursuant to this
Agreement are not limited to the rights granted pursuant to Sections 2.1.1 and 2.1.2 under the Sublicensed Patents. The Parties each agree that as a primary consideration Bioamber receives additional commercial benefits, including, without
limitation, benefits from having access to the Licensed Intellectual Property as allowed hereunder, the reduction or abatement of research expenses that Bioamber would incur absent to access to the Licensed Intellectual Property, the forbearance
obligations on DuPont (as set forth in Sections 2.7.1 through 2.7.1.b, inclusive, and being able to perform Hydrogenation, as licensed hereunder, earlier in time than Bioamber would have been able to do absent the access to the Licensed Intellectual
Property as allowed hereunder. 
 2.5. No Implied Licenses. There are no rights or licenses implied for either Party to practice the
Confidential Information and/or intellectual property of the other Party and /or any Third Party, except as expressly provided and granted in this Agreement. 
 2.6. Owners of the Sublicensed Patents. 
 2.6.1. Bioamber acknowledges that
neither DuPont nor any Affiliate of DuPont can in any way restrict [***] the Sublicensed Patents. Nothing in this Agreement shall create for DuPont or any of its Affiliates any obligation to restrict or attempt to restrict [***] the
Sublicensed Patents. Nothing in this Agreement shall create for Bioamber any remedy in the event [***] the Sublicensed Patents in a manner that is contrary to the interests of Bioamber. 

2.6.2. As neither DuPont nor any Affiliate of DuPont is the owner of the Sublicensed Patents, the Parties agree that neither DuPont nor
any Affiliate of DuPont is under any obligation to prosecute, maintain, or otherwise keep the Sublicensed Patents in force, or enforce the Sublicensed Patents against any Third Party or to require any Third Party to do any of the same. Nothing in
this Agreement shall create for Bioamber any remedy in the event [***] fails to prosecute, maintain, or otherwise keep the Sublicensed Patents [***] in force, or enforce the Sublicensed Patents [***] against any Third Party, even if the
results of such failure by [***] are contrary to the interests of Bioamber. 
 2.6.3. Neither DuPont nor any Affiliate of
DuPont is under any obligation to do any of the following (a) seek, prosecute, maintain, or otherwise keep any intellectual property 

  
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right in the Licensed Intellectual Property or (b) enforce any intellectual property right in the Licensed Intellectual Property against any Third Party or (c) require any Third Party
to do (a) or (b) above. Nothing in this Agreement shall create for Bioamber any remedy in the event DuPont fails to do (a), (b), and/or (c) above. 
 2.6.4. Nothing in this Agreement shall create for Bioamber any remedy in the event [***] performs, or fails to perform, any act, even if the results of such performance/non-performance are contrary
to the interests of Bioamber. Without limiting the foregoing, nothing in this Agreement shall create for Bioamber any remedy in the event [***] publishes any portion of the [***]. 

2.7. Exclusivity with Respect to DuPont. 
 2.7.1. During the Exclusion Period and so long as Bioamber has not breached any material provision of this Agreement, DuPont shall not do any of the following: 

a. grant to any Third Party a sublicense to any of the rights granted Bioamber pursuant to Sections 2.1 through 2.2.1.d, inclusive, or

 b. to the extent DuPont may so forebear without violating an obligation to a Third Party (such Third Parties to include
without limitation, [***]), share the contents of any of the Licensed Intellectual Property with Third Parties, other than as required for DuPont to practice on its own behalf, as permitted under this Agreement. 

2.7.2. It shall not be considered a breach of DuPont’s forbearance obligations set forth in this Agreement, nor shall Bioamber or any
of its sublicensees gain any remedy, if DuPont shares the contents of the Licensed Intellectual Property in response to a request by any legal or regulatory authority to do so, or in any legal action or proceeding. 

2.7.3. For so long as this Agreement is in effect, absent the express written permission of Bioamber, DuPont shall not use the Sublicensed
Patents nor the Licensed Intellectual Property to make Hydrogenation Products from succinic acid. Nothing in this Agreement shall be interpreted as limiting DuPont’s right to [***]. 

2.8. Technical Reports. Within ten (10) days of the Effective Date, DuPont shall provide the Technical Reports to Bioamber. 

2.9. Technical Know-how. DuPont shall provide Technical Know-how to Bioamber to clarify the technical information concerning Hydrogenation and the
Technical Reports licensed pursuant to Section 2.1.1 and 2.1.2, as follows: 
 2.9.1. DuPont shall expend up to [***]
person-days, tallied in [***] increments, making a good faith effort to provide answers to questionnaires submitted by Bioamber during the first twelve (12) months after the Effective Date, provided that  

a. such responses do not require DuPont to violate an obligation it has to any Third Party (such Third Parties to include without
limitation, [***]) with respect to information Bioamber desires to be included in such response, and 
 b. nothing in this
Agreement obligates DuPont to perform any searches of external records or perform any experimental work or perform any other act than a review of its readily available internal records to provide a response to the questionnaires. 

  
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 2.9.2. During the [***] years following the Effective Date, at Bioamber’s
request, DuPont may expend efforts preparing written responses to questionnaires submitted by Bioamber after the twelve (12) month anniversary of the Effective Date and/or requiring the expenditure of effort by DuPont in addition to the
[***] person-days set forth in Section 2.9.1 at DuPont’s sole discretion, such additional effort to be provided, if DuPont decides to so provide, at a cost to Bioamber of [***] per day, billed in [***] increments.
DuPont shall invoice Bioamber for any fees or expenses incurred pursuant to this Section. 
 2.10. Catalyst Suppliers. During the first
[***] of the Term, DuPont shall provide to Bioamber (a) manufacturing protocols for Catalysts, (b) a list of the Third Parties that manufacture Catalysts [***] Catalysts, and (c) Catalyst [***]. 

2.11. Provision of Hydrogenation Products to DuPont. Bioamber agrees that it will, at DuPont’s request, negotiate in good faith with DuPont
concerning entering into an agreement with DuPont regarding the supply of Hydrogenation Products to DuPont. Any agreement resulting from such negotiations will obligate Bioamber to [***]. 

2.12. Improvements. 

2.12.1. DuPont shall be under no obligation to make any further development or improvement to, in connection with, the Licensed
Intellectual Property. 
 2.12.2. The rights granted pursuant to Sections 2.1.1 and/or 2.1.2 includes the right for Bioamber to
further develop the inventions claimed in the Sublicensed Patents and Licensed Intellectual Property within the scope of the license rights granted in Sections 2.1.1 and/or 2.1.2. Such development shall be directed, namely and without limitation,
towards methods of manufacturing Hydrogenation Products using a biobased succinic acid feedstock. 
 2.12.3. As part of such
further development, Bioamber will test the Catalysts with succinic acid derived from Bioamber’s fermentation broth and proprietary downstream purification process. Bioamber will communicate the results of such evaluations to DuPont, which
results shall be considered as Confidential Information of Bioamber. 
 2.12.4. The Parties acknowledge and agree that
[***]. 
 2.12.5. Bioamber shall have the right at its own discretion to secure intellectual property protection in any of
the Improvements at its own expense. 
 2.12.6. Bioamber shall report all Improvements to DuPont promptly after the creation of
such Improvement. 
 2.12.7. Bioamber shall provide DuPont with a semi-annual summary report regarding any further evaluations
of, development in, or improvement to, the Licensed Intellectual Property. Such reports will include any Improvements made by Bioamber. Such reports will be sent to DuPont at the address set forth in Section 8.1. 

 

	2.13.	[***]. 

  

	2.14.	[***]. 

 2.14.1.
[***]. 
 2.14.2. [***]. 

  
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	3.	PAYMENTS 

 3.1. Initial Payment.
Bioamber shall make a lump-sum payment to DuPont of [***], within ten (10) days following the Effective Date, which payment shall not be creditable or refundable in any event. 
 3.2. Royalties. In further consideration of the non-exclusive rights granted in Sections 2.1 through 2.2.3, , inclusive, and the commercial benefits afforded Bioamber thereby, as noted in
Section 2.4, Bioamber shall pay DuPont the following amounts, subject to Section 3.4.2 
 3.2.1. [***]
percent [***] of all consideration received by Bioamber, including without limitation, [***]; and 
 3.2.2.
[***] percent [***] of net sales of Hydrogenation Products [***], less (a) [***] invoiced to the Third Party transferee of the Hydrogenation Products and (b) [***] and (c) [***], all as determined
according to standard accounting practices. 
 3.2.3. Notwithstanding the foregoing, no royalty will be paid on Bioamber sales of
Hydrogenation Products to DuPont from Bioamber that [***]. 
 3.3. Minimum Royalties. The following minimum annual royalty
payments shall be paid by Bioamber to DuPont to maintain the non-exclusive rights granted in Sections 2.1 through 2.2.3, inclusive: 
 3.3.1. Subject to Section 3.4.2, within thirty (30) days following the first anniversary of the Effective Date, Bioamber will pay DuPont a minimum royalty of [***], less any amount paid
by Bioamber to DuPont pursuant to Sections 3.2 through 3.2.2, inclusive, during the twelve (12) months preceding the first anniversary of the Effective Date. 
 3.3.2. Within thirty (30) days following the second anniversary of the Effective Date and each subsequent anniversary of the Effective Date thereafter, subject to Section 5.4, Bioamber will pay
DuPont a minimum royalty of [***], less any amount paid by Bioamber to DuPont pursuant to Sections 3.2 through 3.2.2, inclusive, during the twelve (12) months preceding the relevant anniversary of the Effective Date. 

3.4. Infringement Claims by Third Parties. 
 3.4.1. If the practice of the license rights granted pursuant to this Agreement results in a Third Party bringing a claim, suit or proceeding alleging patent infringement against Bioamber, Bioamber shall
promptly notify DuPont in writing setting forth the facts of such claim in reasonable detail. 
 3.4.2. Royalty Abatement.
If it is impossible for Bioamber to practice the rights granted pursuant to Sections 2.1.1 and/or 2.1.2 without obtaining a license from the Third Party asserting an infringement claim pursuant to Section 3.4 and Bioamber takes a license
directly from the party alleging infringement, DuPont shall [***] set forth in Sections 3.2.1 and/or 3.2.2 and [***] set forth in Section 3.3.1 and 3.3.2 by an amount equal to [***] percent [***] of the royalties
[***], provided that in no event shall the [***] set forth immediately above be [***]. 
 3.5. Invoices for Additional
Technical Know-how. If DuPont expends any effort providing Technical Know-how to Bioamber pursuant to Section 2.9.2, Bioamber shall pay invoices from DuPont for such efforts within thirty (30) days of Bioamber’s receipt thereof.

  
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 3.6. Payment Period. 
 3.6.1. Bioamber and DuPont each understands and agrees as follows: 
 a. all the
Sublicensed Patents are set to expire prior to the end of the Term; 
 b. the Sublicensed Patents could each be abandoned or be
held invalid or unenforceable at any time prior to their scheduled expiration date; 
 c. and the Licensed Intellectual Property
could become part of the public domain as a result of the actions of [***] or any Third Party to whom [***] has provided the Licensed Intellectual Property; and 
 d. the Parties have established the payment schedules set forth in this Agreement as a method of amortizing the financial consideration to be provided by Bioamber in return for the timeliness of benefits
accruing to Bioamber hereunder, such benefits to include without limitation, the rights granted pursuant to Sections 2.1.1 and 2.1.2 and the commercial benefits set forth in Section 2.4. 

3.6.2. As a result of the forgoing, the Parties each agree that Bioamber’s obligation to pay royalties and minimum royalties to
DuPont as set forth in Sections 3.2 through 3.3.2, inclusive, shall continue through the Term, regardless of the status of the Sublicensed Patents or of the Licensed Intellectual Property, unless this Agreement is terminated pursuant to
Section 6.2 or 6.3.3, in which case Bioamber’s obligation to pay royalties and minimum royalties to DuPont as set forth in Sections 3.2 through 3.3.2, inclusive, shall terminate at the date of termination of this Agreement. 

3.7. Reports. Subsequent to the lump sum payment pursuant to Section 3.1, Bioamber shall report in writing to DuPont, within thirty
(30) days after the end of each anniversary date of the Effective Date, the royalty payments and net sales of Hydrogenation Products subject to royalty payments pursuant to Article 3 during the prior twelve (12) month period. If there were
no such royalties or sales, a report nevertheless shall be submitted so stating. Payment shall be submitted to DuPont concurrent with submission of the report. Unless DuPont notifies Bioamber otherwise, the report shall be submitted to: 

E. I. du Pont de Nemours and Company 
 Attention: Royalty Accounting 
 BMP 24-1209. 

4417 Lancaster Pike 
 Wilmington, DE 19880-0024 
 A copy of the report shall be submitted concurrently to the office
receiving notices for DuPont in accordance with Section 8.1. 
 3.8. United States Dollars. 

3.8.1. Unless DuPont notifies Bioamber otherwise, all payments due to DuPont hereunder shall be in U.S. Dollars and shall be submitted by
wire transfer to: 
 [***] 
 3.8.2. In the event that royalties accrue in a currency other than U.S. Dollars, the royalties shall be converted into U.S. Dollars at the closing buying rate of the JPMorgan Chase Bank in effect on the
last business day of the accounting period for which payment is due; provided, however, DuPont may notify Bioamber, for future payments, of (a) another published currency conversion standard that shall apply, or (b) wire transfer
instructions for payment of royalties in the currency in which the royalties accrued. 

  
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 3.9. Late Payments. If any payment due hereunder is not paid when due, the unpaid amount shall bear
interest at an annual rate of interest calculated at the Federal Reserve Prime Rate as reported by the Wall Street Journal on the date such payment is due, plus an additional [***], calculated on the number of days such payment is delinquent.
Such interest shall accrue on the balance of unpaid amounts from the date such amounts become due until payment in full. The penalty and interest available to DuPont pursuant to this Section shall in no way limit any other remedies available to
DuPont. 
 3.10. Record Retention. Bioamber shall keep, and require its sublicensees of the rights granted pursuant to Section 2.1.1
and/or 2.1.2 to keep, adequate records in sufficient detail to audit to completion Bioamber’s performance under, and compliance with, the terms of this Agreement and to verify the payments accrued, made, or to be made, and the accuracy of any
reports provided hereunder. Bioamber shall maintain such records for at least three (3) years following the date on which a royalty report is due. 
 3.11. Audit Rights. 
 3.11.1. DuPont shall have the right, upon fifteen
(15) days notice to Bioamber, to audit during regular business hours, those records deemed by the auditor to be reasonably necessary to audit to completion Bioamber’s performance under, and compliance with, this Agreement and to verify the
payments accrued, made, or to be made, and the accuracy of any reports provided hereunder. During such examination, the auditor’s right to examine includes without limitation those records required to maintained pursuant to Section 3.10,
as well as production and shipping logs and meeting notes and memoranda. 
 3.11.2. The auditor shall have the right, following
reasonable notice to Bioamber, to interview, during regular business hours, Bioamber’s employees or contractors who may have access to information deemed by the auditor to be reasonably necessary to audit to completion Bioamber’s
performance under, and compliance with, this Agreement and to verify the payments accrued, made, or to be made, and the accuracy of any reports provided hereunder. 
 3.11.3. The auditor shall be required to agree to terms of confidentiality consistent with this Agreement with respect to any confidential information it receives, provided that such agreement shall not
prohibit the reporting to DuPont of any finding under the Audit. Bioamber shall require any sublicensees of the rights granted in Sections 2.1.1 and 2.1.2 to maintain such records as are required under this Agreement. Bioamber shall require any such
sublicensees to allow DuPont to exercise the examination and interview rights granted hereunder with respect to any such sublicensee. . 
 3.11.4. Such examination and/or interviews shall not take place more often than once a year, nor cover any records or information that date prior to the date of the last such examination/interview.

 3.11.5. In the event the report demonstrates that Bioamber has underpaid any amount contemplated hereunder, Bioamber shall
promptly pay such amount together with interest calculated pursuant to Section 3.9. 
 3.11.6. If any such audit
reveals that Bioamber has underpaid DuPont by [***] of the amount that was due DuPont, Bioamber shall reimburse DuPont’s expenses incurred in conducting the audit. Such reimbursement shall be due as of the date DuPont notifies Bioamber of the
shortage causes the reimburse obligation to arise. 

  
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	4.	CONFIDENTIAL INFORMATION 

 4.1.
Confidentiality and Non-Use. Confidential Information disclosed by a Disclosing Party to a Receiving Party shall be maintained in strict confidence by the Receiving Party, and not used for any purpose other than those authorized by this
Agreement, for [***] year period commencing from the Effective Date. Without limiting the foregoing, the Receiving Party shall not use Confidential Information to compete with or adversely affect the business or operations of the Disclosing
Party or its Affiliates or those doing business with them. The Receiving Party may disclose Confidential Information to the Receiving Party’s Representatives on a “need to know” basis, so long as such Representatives agree to be bound
by the obligations of confidentiality and non-use set forth in this Agreement or at least as strict as those set forth in this Agreement. The Receiving Party shall be responsible for any breach of the obligations of confidentiality and non-use set
forth in this Agreement by any of the Receiving Party’s Representatives. 
 4.2. Required Disclosure. If a Receiving Party is
required by law to disclose any Confidential Information, such Receiving Party shall (a) notify the Disclosing Party of such requirement sufficiently in advance of such required disclosure in order to permit the Disclosing Party to take steps
to prevent such disclosure, and (b) prior to any disclosure consult with and assist the Disclosing Party in obtaining a protective order or other appropriate measure. In any event, the Receiving Party will disclose only that portion of the
Confidential Information which is legally required and will use best efforts to assure that confidential treatment is accorded any Confidential Information so disclosed. 
 4.3. Equitable Relief. The Receiving Party acknowledges that (a) the Confidential Information disclosed to the Receiving Party by the Disclosing Party is the trade secret information of the
Disclosing Party, (b) any breach of the obligations of confidentiality and/or non-use set forth herein may cause irreparable harm to the Disclosing Party, (c) in the event of such breach, damages alone will not be an adequate remedy to the
Disclosing Party, and (d) in addition to all other remedies to which the Disclosing Party may be entitled hereunder or otherwise, the Disclosing Party may be entitled to injunctive relief, including specific performance, with respect to said
obligations in any court of competent jurisdiction. 
 4.4. Return of Confidential Information. Upon request by the Disclosing Party at
any time, the Receiving Party will promptly destroyed or return to the Disclosing Party (at the Disclosing Party’s sole option) the original and all copies of all the Disclosing Party’s Confidential Information and will, upon request,
certify in writing to the Disclosing Party as to the Receiving Party’s compliance with this paragraph, except that the Receiving Party may keep one (1) copy for archival purposes only. 

4.5. No Grant of Rights. Except as expressly set forth in this Agreement, the Receiving Party shall not be deemed to receive any right or license
under any Confidential Information disclosed by a Disclosing Party pursuant to this Agreement. 
 4.6. Press Release. Bioamber may not
issue any press release, advertisement, or any other communication concerning this Agreement, without the express written consent of DuPont. The Parties agree to release a press release of the form attached to this Agreement as Schedule C after the
exact wording of such a press release has been agreed to by the Parties. The exact wording of the press release shall be agreed to by the Parties within thirty (30) days of the Effective Date. The parties may issues future additional press
releases as the Parties may agree. 

  
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	5.	WARRANTIES AND LIMITATIONS 

 5.1.
Representation. DUPONT REPRESENTS THAT IT HAS THE RIGHT TO GRANT THE RIGHTS GRANTED PURSUANT TO SECTIONS 2.1.1 AND 2.1.2 OF THIS AGREEMENT. 
 5.2. No Warranty of Success. DUPONT DOES NOT WARRANT OR GUARANTEE THAT ANY SUCCESSFUL COMMERCIAL RESULTS WILL BE OBTAINED BY BIOAMBER AS A RESULT OF EXERCISING THE RIGHTS GRANTED PURSUANT TO THIS
AGREEMENT. NEITHER DUPONT NOR ANY OF ITS AFFILIATES SHALL BE LIABLE TO BIOAMBER OR ANY OF BIOAMBER’S SUBLICENSEES BECAUSE OF ANY FAILURE IN BIOAMBER AND/OR ITS SUBLICENSEES OPERATIONS. 
 5.3. General Disclaimer of Warranty. THERE ARE NO OTHER WARRANTIES, EXPRESS OR IMPLIED, OTHER THAN THOSE EXPRESSLY EXTENDED IN THIS ARTICLE 5. 

5.4. No Warranty of Additional Obligation. DUPONT DOES NOT WARRANT OR GUARANTEE THAT BIOAMBER OR ANY OF ITS SUBLICENSEES OF THE RIGHTS GRANTED
PURSUANT TO SECTION 2.1.1 AND/OR 2.1.2 MAY PRACTICE THE RIGHTS GRANTED PURSUANT TO SECTIONS 2.1.1 AND/OR 2.1.2 ABSENT OBTAINING LICENSE RIGHTS FROM ANY THIRD PARTY, REGULATORY APPROVAL, AND/OR PERMITS. NEITHER DUPONT NOR ANY OF ITS AFFILIATES SHALL
BE LIABLE TO BIOAMBER OR ANY OF BIOAMBER’S SUBLICENSEES FOR COSTS INCURRED BY BIOAMBER OR ANY OF BIOAMBER’S SUBLICENSEES IN CONNECTION WITH OBTAINING ANY SUCH LICENSE RIGHTS, REGULATORY APPROVAL, AND/OR PERMIT. 

5.5. Confidential Information. Any Confidential Information provided hereunder is provided “AS IS,” without warranty of any kind,
including, without limitation, any warranty of non-infringement. 
 5.6. LIMITATION OF LIABILITY. IN THE EVENT BIOAMBER BRINGS AGAINST
DUPONT ANY CLAIMS, SUITS, OR CAUSES OF ACTION, SEEKING DAMAGES (INCLUDING, WITHOUT LIMITATION, ALL CLAIMS, AWARDS FOR DAMAGES, ATTORNEY FEES, COURT COSTS, INTEREST, PENALTIES, ETC.), IN ANY WAY RELATED TO THIS AGREEMENT OR ANY RIGHTS LICENSED TO
BIOAMBER UNDER THIS AGREEMENT OR ANY INFORMATION PROVIDED BY DUPONT TO BIOAMBER UNDER THIS AGREEMENT (INCLUDING WITHOUT LIMITATION A BREACH BY DUPONT OF ANY WARRANTY, REPRESENTATION OR OBLIGATION UNDER THIS AGREEMENT), BIOAMBER AGREES THAT THE TOTAL
COMBINED LIABILITY (INCLUDING, WITHOUT LIMITATION, LIABILITY FOR ALL CLAIMS, AWARDS FOR DAMAGES, ATTORNEY FEES, COURT COSTS, INTEREST, PENALTIES, ETC.) OF ALL DUPONT INDEMNITEES TO BIOAMBER RESULTING FROM ALL SUCH CLAIMS, SUITS, OR CAUSES OF ACTION
SHALL BE NO GREATER THAN FOUR HUNDRED THOUSAND DOLLARS ($400,000.00). 
 5.7. SPECIAL DAMAGES. NEITHER PARTY SHALL BE RESPONSIBLE TO THE
OTHER FOR SPECIAL, INCIDENTAL, EXEMPLARY, OR CONSEQUENTIAL DAMAGES THAT MAY BE INCURRED PURSUANT TO THIS AGREEMENT OR PERFORMANCE HEREUNDER. 

  
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 5.8. HEALTH AND SAFETY. DUPONT DOES NOT WARRANT OR GUARANTEE THAT THE EXERCISE OF THE RIGHTS GRANTED
PURSUANT TO THIS AGREEMENT AND THE USE OF ANY PRODUCTS MADE PURSUANT TO THE PRACTICE OF SUCH RIGHTS WILL NOT RESULT IN SAFETY OR HEALTH HAZARDS TO WORKERS, THE ENVIRONMENT, OR TO PURCHASERS OF SUCH PRODUCTS. 

5.9. INDEMNIFICATION BY BIOAMBER. BIOAMBER HAS SOLE DISCRETION AND RESPONSIBILITY FOR ITS DESIGN, MAKING, MANUFACTURE, AND SALE OF PRODUCTS
PURSUANT TO THIS AGREEMENT. ACCORDINGLY, TO THE EXTENT PERMITTED BY THE LAW OF THE STATE OF DELAWARE, UNITED STATES OF AMERICA, BIOAMBER SHALL INDEMNIFY, DEFEND, AND HOLD THE DUPONT INDEMNITEES HARMLESS FROM AND AGAINST ANY AND ALL CLAIMS, SUITS,
OBLIGATIONS, CAUSES OF ACTION, LIABILITY, COSTS AND DAMAGES (INCLUDING, WITHOUT LIMITATION, ALL CLAIMS, AWARDS FOR DAMAGES, ATTORNEY FEES, COURT COSTS, INTEREST, PENALTIES, ETC), INJURIES TO PERSONS (INCLUDING DEATH) OR PROPERTY (INCLUDING, WITHOUT
LIMITATION, LOSS OF USE), PRODUCT LIABILITY CLAIMS, CLAIMS FOR PATENT INFRINGEMENT, CLAIMS BY THE OWNER OF THE SUBLICENSED PATENTS THAT PRACTICING HYDROGENATION AS PERFORMED BY BIOMABER VIOLATES THE TERMS OF ANY AGREEMENT [***] HAS WITH
DUPONT (EXCEPTING [***]), AND CLAIMS FOR DAMAGE TO THE ENVIRONMENT (COLLECTIVELY, “LIABILITIES”), WHATEVER THE CAUSE MAY BE, BASED UPON, ARISING OUT OF, OR RELATED TO THE ACTS OR OMISSIONS OF BIOAMBER AND ITS AFFILIATES AND/OR ANY
OF THEIR EMPLOYEES, OFFICERS, EMPLOYEES, AND CONSULTANTS,SUBLICENSEES OR OTHER PERSONS ACTING ON THEIR BEHALF OR UNDER THEIR CONTROL, IN CONNECTION WITH BIOAMBER’S AND/OR ANY BIOAMBER SUBLICENSEES’ EXECUTION, DELIVERY AND PERFORMANCE OF,
OR FAILURE TO PERFORM, THIS AGREEMENT, INCLUDING, WITHOUT LIMITATION, LIABILITIES ARISING OUT OF THE NEGLIGENCE OR WILLFUL MISCONDUCT OF ANY OF THE DUPONT INDEMNITEES, EXCEPT TO THE EXTENT THAT SUCH LIABILITIES ARE ESTABLISHED IN A COURT OF LAW TO
HAVE BEEN CAUSED SOLELY AND DIRECTLY BY THE NEGLIGENCE OR WILLFUL MISCONDUCT ON THE PART OF ANY OF THE DUPONT INDEMNITEES. 
 5.10.
Insurance. 
 5.10.1. Bioamber, at its expense, shall carry and maintain in force at all times relevant hereto the
following insurance, on policy forms and with insurance companies authorized to do business in the jurisdiction(s) where work is to be performed and acceptable to DuPont , at the indicated minimum coverage limits. Such insurance coverage shall be of
an “occurrence-based” basis, or Bioamber shall secure and maintain “tail insurance” coverage for acts occurring during the Term. DuPont shall be named as a loss payee and co-insured thereon (except for the policy for
Worker’s Compensation). Bioamber shall provide proof of such insurance to DuPont upon request. In the event DuPont has requested proof of such coverage and Bioamber has not provided such proof to DuPont within thirty (30) days of such
request, DuPont may obtain such coverage for Bioamber, at Bioamber’s expense, if the same is not obtained and proof thereof given to DuPont. 

  
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 a. Workers’ Compensation - Statutory; Employer’s Liability - [***] per
accident/per employee; and such other insurance as may be required by Statutory law. This policy shall include a waiver of subrogation to DuPont. The obligation set forth in this Section is shall only apply if Bioamber builds and/or operates plants
producing Hydrogenation Products. 
 b. Commercial General Liability (Occurrence Form), including Contractual Liability and
liability for Products and Completed Operations, in a combined limit for Bodily Injury and Property Damage - [***] per occurrence. This policy shall name DuPont as additional insured. 

c. Other insurance appropriate for Bioamber’s business or as required by law. 

5.10.2. Bioamber shall maintain in force the insurance required by Sections 5.10.1 through 5.10.1.c, inclusive, and shall seasonably renew
all required coverage during the Term. 
 5.10.3. Upon the request of DuPont, Bioamber shall provide DuPont with certificates of
insurance evidencing the coverage. Such certificates shall be on a standard insurance industry form and underwritten by a carrier with an AM Best rating of A- or above. Such certificates shall provide that the insurer will give DuPont at least
thirty (30) days advance notice of any changes in, or cancellation or non-renewal of, coverage and note any exclusions. 

5.10.4. Bioamber shall require that any sublicensee carry the same coverage in the same limits as set out above and other coverage as
Bioamber deems appropriate and shall provide proof of such coverage. 
 5.10.5. Bioamber shall require that any subcontractor it
employs carry the same coverage in the same limits as set out above and other coverage as Bioamber deems appropriate and shall provide proof of such coverage. 
 5.10.6. Neither failure of Bioamber to comply with any or all of the insurance sections of the Agreement, nor the failure to secure endorsements on policies as may be necessary to carry out the terms and
sections of the Agreement, shall be construed to limit or relieve Bioamber from any of its obligations under the Agreement. 
  

	6.	TERM AND TERMINATION 

 6.1. Term.
This Agreement shall be in effect for the Term, unless earlier terminated in accordance with this Agreement. 
 6.2. Termination Without
Cause. During the Development Period, Bioamber may terminate this Agreement at any time, and for any reason whatsoever, by providing DuPont with thirty (30) days advance written notice of termination. Such termination shall be effective
thirty (30) days after DuPont’s receipt of the notice. 
 6.3. Termination for Cause. 

6.3.1. If Bioamber breaches, or defaults in the performance of, or fails to be in compliance with, any material warranty, representation,
agreement or covenant of this Agreement, other than a breach of its obligation to make any payment due under Article 

  
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3, and such default or noncompliance shall not have been substantially remedied, or steps initiated to substantially remedy the same to DuPont’s reasonable satisfaction, within sixty
(60) days after receipt by Bioamber of a written notice thereof and demand to cure such default from DuPont, DuPont may terminate this Agreement. DuPont shall so terminate by providing a written notice of termination, and such termination shall
be effective as of the date of Bioamber’s receipt of the notice of termination. 
 6.3.2. If Bioamber breaches, or defaults
in the payment of any payment due under Article 3, and such default or noncompliance shall not have been substantially remedied, or steps initiated to substantially remedy the same to DuPont’s reasonable satisfaction, within thirty
(30) days after receipt by Bioamber of a written notice thereof and demand to cure such default from DuPont, DuPont may terminate this Agreement. DuPont shall so terminate by providing a written notice of termination, and such termination shall
be effective as of the date of Bioamber’s receipt of the notice of termination. 
 6.3.3. If DuPont breaches, or defaults in
the performance of, or fails to be in compliance with, any material warranty, representation, agreement or covenant of this Agreement, and such default or noncompliance shall not have been substantially remedied, or steps initiated to substantially
remedy the same to Bioamber’s reasonable satisfaction, within sixty (60) days after receipt by DuPont of a written notice thereof and demand to cure such default from Bioamber, Bioamber may terminate this Agreement. Bioamber shall so
terminate by providing a written notice of termination, and such termination shall be effective as of the date of DuPont’s receipt of the notice of termination. 
 6.4. Bankruptcy. Should Bioamber (1) become insolvent or unable to pay its debts as they mature, or (2) make an assignment for the benefit of creditors, or (3) permit or procure the
appointment of a receiver for its assets, or (4) become the subject of any bankruptcy, insolvency or similar proceeding, then DuPont may at any time thereafter terminate this Agreement. DuPont shall so terminate by providing a written notice of
termination, and such termination shall be effective as of the date of Bioamber’s receipt of the notice of termination. 
 6.5.
Termination for Patent Challenge. 
 6.5.1. In the event that Bioamber brings any Patent Challenge (except as required
under a court order or subpoena) then DuPont may immediately terminate this Agreement. DuPont shall so terminate by providing a written notice of termination, and such termination shall be effective as of the date of Bioamber’s receipt of the
notice of termination. 
 6.5.2. In the event that any such Patent Challenge brought by Bioamber is unsuccessful, Bioamber shall
reimburse DuPont for all reasonable legal fees and expenses incurred in its defense of the Patent Challenge. 
 6.6. Effect of
Termination. 
 6.6.1. On the date this Agreement is terminated for any reason prior to the end of the Term (the “Early
Termination Date”), Bioamber shall immediately cease performing Hydrogenation using the Sublicensed Patents and the Licensed Intellectual Property until the later of (a) the termination/expiration of the last to terminate/expire of the
Sublicensed Patents or (b) the end of the Exclusion Period. 

  
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 6.6.2. Early termination of this Agreement shall not affect the rights and obligations of
either Party incurred prior to termination. For example, obligations to make payments then due, and to maintain Confidential Information in confidence, shall survive termination. Upon termination, each Party shall return Confidential Information of
the other Party, or destroy it, as the Disclosing Party shall instruct, and cease any use of Confidential Information of the other Party. 
 6.6.3. If this Agreement is terminated prior to the end of the Term other than pursuant to Section 6.3.3, Bioamber hereby grants to DuPont, (a) a non-exclusive, worldwide, royalty-free license
to use the Improvements, (b) a non-exclusive, worldwide, royalty-free license to any other know-how or developments made by or on behalf of Bioamber pursuant to Section 2.12 through 2.12.7, inclusive, related to the Sublicensed Patents
and/or the Licensed Intellectual Property, and (c) a non-exclusive, worldwide, royalty-free license to any license rights obtained by or on behalf of Bioamber that are necessary or desirable to allow DuPont to grant licenses pursuant to
Section 2.2.2. 
 6.6.4. If this Agreement is terminated prior to the end of the Exclusion Period other than pursuant to
Section 6.3.3, DuPont’s obligations set forth in Sections 2.7 through 2.7.1.b, inclusive, shall terminate concurrently with the termination of this Agreement. 
 6.7. Termination Not Sole Remedy. Unless otherwise specified, termination is not the sole remedy under this Agreement and, whether or not termination is effected, all other remedies will remain
available except as expressly agreed to herein. 
 6.8. Provision of Documents and Information. In addition to Bioamber’s obligation
to return or destroy DuPont Confidential Information pursuant to Section 4.4, within ten (10) days of the termination or expiration of this Agreement, Bioamber shall (a) destroy or return to DuPont (at DuPont’s sole option) the
original and all copies of all DuPont’s Confidential Information (except that Bioamber may keep one (1) copy for archival purposes only); (b) destroy or return to DuPont (at DuPont’s sole option) all documents containing
derivative information based on such Confidential Information; and provide DuPont with copies of tangible embodiments of any other know-how or developments made by or on behalf of Bioamber pursuant to Section 2.12 through 2.12.7, inclusive,
related to the Sublicensed Patents and/or the Licensed Intellectual Property. Bioamber will, upon DuPont’s request, certify in writing to DuPont as to Bioamber’s compliance with this Section 

6.9. Survival. The provisions of Sections 2.6.1 through 2.6.4, inclusive, 3.9 through 3.11.6, inclusive, 6.7, and 6.9 and Articles 1, 4, 5, and 8
shall survive the expiration or termination of this Agreement. The obligation to pay amounts accrued under Article 3 prior to termination shall survive the expiration or termination of this Agreement. For the sake of clarity, the Parties each agree
that the obligation to pay royalties and minimum royalties set forth in Sections 3.2 through 3.3.2, inclusive, shall not survive early termination of this Agreement. 
  

	7.	DISPUTE RESOLUTION. 

 7.1. Senior
Executive Panel. If any dispute or claim arising under the Agreement cannot be readily resolved by the Parties, the Parties shall refer the matter to a panel consisting of one (1) senior executive from each party for review and resolution.
The senior executive shall not have been directly involved in the claim or dispute. A copy of the Agreement terms, relevant facts, areas of disagreement, and concise summary of the basis for each side’s contentions will be

  
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provided to both executives who shall review the same, confer, and attempt to reach a mutual resolution of the issue. The senior executives shall attempt to meet in person or by phone and resolve
the dispute within thirty business (30) days of their appointment. 
  

	7.2.	Mediation. 

 7.2.1. If the
dispute cannot be resolved by the senior executive panel within ten (10) days of the date of the senior executive’s conference, then the Parties shall submit the matter to mediation within thirty (30) days thereafter in accordance
with the rules of the American Arbitration Association, as modified herein, and each Party shall bear equally the costs of the mediation. Unless otherwise agreed by the Parties, the mediation will take place in Wilmington, Delaware. 

7.2.2. The Parties will jointly appoint a mutually acceptable mediator, seeking assistance in such regard from the American Arbitration
Association if they are unable to agree upon such appointment within twenty (20) days from the conclusion of the negotiation period. 
 7.2.3. The Parties agree to participate in good faith in the mediation and negotiations related thereto for a period of thirty (30) days or such longer period as they may mutually agree following the
initial mediation session. 
 7.2.4. The mediator, prior to any proceedings hereunder, will sign an agreement whereby any such
mediator(s) agrees to keep the existence and substance of any proceedings hereunder in confidence. 
 7.3. Legal /Equitable Remedy. In
the event the mediation fails to yield mutually satisfactorily results, nothing herein, however, shall preclude either Party from seeking remedy of a dispute in a court of law or equity in accordance with Section 8.2. 

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	8.	MISCELLANEOUS 

 8.1. Notices. Any
notice or other communication required or permitted to be given by either Party under this Agreement shall be in writing and shall be effective when delivered, if delivered by hand or by electronic facsimile or by courier or five (5) days after
mailing if mailed by registered or certified mail, postage prepaid and return receipt requested. All such notices shall be addressed to each Party at the following addresses or such other address an may be designated by notice pursuant to this
Section: 
  

			
	 If to DuPont:
 E. I. du Pont de Nemours and Company
 Intellectual Assets &
Licensing
 Experimental Station 268/303
 P.O. Box 80268
 Wilmington, DE 19880-0268

Attn: Howard L. Hertzberg
 Phone: [***]
 Facsimile: (302) 695-1437
	 	 If to Bioamber:
 Bioamber s.a.s.
 1250 Rene-Levesque West, Suite 4110

Montreal, Quebec, Canada
 H3B 4W8
 Attn: Mr. Jean-François Huc, Director General

Phone : (514) 844-8000
 E-Mail : [***]
 Facsimile : (514) 844-5836

		 	 With a copy to :
 Boivin Desbiens Senecal, g.p.
 2000 McGill College, Suite 2000

Montreal, Quebec, Canada
 H3A 3H3
 Attn : Mr. Thomas Desbiens, Esq.

Phone: (514) 844-5468
 E-Mail: [***]
 Facsimile: (514) 844-5836

 8.2. Choice of Law. The validity, interpretation and performance of this Agreement and any disputes arising
thereunder shall be governed and construed in accordance with the laws of the State of Delaware, without regard to the conflict of law principles thereof. This Agreement shall not be governed by the U.N. Convention on Contracts for the International
Sale of Goods. Any legal action arising from a dispute or question regarding the terms and conditions, or performance of this Agreement may be instituted only in the appropriate court for the State of Delaware or the United States District Court for
the District of Delaware. Matters between the Parties pertaining to the validity or enforceability of United States Sublicensed Patents shall be instituted only in the United States District Court for the District of Delaware. Matters pertaining to
the validity or enforceability of Sublicensed Patents, other than United States Sublicensed Patents, shall be interpreted and enforced in accordance with the laws of the territory in which such Sublicensed Patents exist. The Parties consent to the
personal jurisdiction and waive any objection to the venue of these courts. The Parties further consent that any service of process may be served by overnight courier or express mail at the respective addresses stated in Section 8.1.

 8.3. Assignment. This Agreement may be assigned or transferred by a Party to such entity that is the successor to substantially all of
those business assets of the Party to which this Agreement applies, provided that the Party gives written notice thereof to the other Party within a reasonable time and such successor agrees in writing to abide by the terms and conditions hereof.
Either Party may delegate performance hereunder, in whole or in part, to an Affiliate(s), but shall remain responsible for performance of its obligations hereunder. Notwithstanding the above, Bioamber shall not, and shall have no right to, assign
this Agreement (a) any entity that DuPont would be barred from entering into the Agreement with under an law or regulation or (b) any entity in a country listed in Country Group E of the CFR Section 15 Supplement 1 to Part 740.

  
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 8.4. Compliance with Laws. The Parties shall abide by the laws and regulations of the United States,
including, without limitation, Export Control and related regulations that pertain to the export of technology. 
 8.5. Independent
Contractors. Each Party shall remain an independent contractor. Nothing herein shall be construed as creating an agency or joint venture relationship between the Parties 
 8.6. Entire Agreement; Merger. This Agreement constitutes the entire agreement between the Parties concerning the subject matter contained herein. Any prior agreement between the Parties is
subsumed by this Agreement. Any modifications shall be in writing, duly signed by both Parties. Any prior agreement, arrangement or undertaking, whether oral or in writing is hereby superseded. 

8.7. Force Majeure. No Party shall be liable for any failure or delay in performance under this Agreement to the extent that, and for the period
that, such failure or delay arises from Force Majeure and the affected Party has informed the other Party within five (5) business days in detail of the Force Majeure event. A Force Majeure consists of an event beyond the reasonable control of
the affected Party and includes, without limitation, fire, explosion, earthquake, storm, flood, strike, labor difficulties, war, insurrection, riot, act of God or the public enemy, or any law, act, order, export or import control regulations,
proclamation, decree, regulation, ordinance, or instructions of local, state, federal or foreign governmental or other public authorities, or judgment or decree of a court of competent jurisdiction (but excluding a court injunction against a
Party’s performance) and not otherwise arising out of breach by such Party of this Agreement. In the event of the occurrence of such an event, the Party so affected shall give prompt written notice to the other Party, stating the period of time
the occurrence is expected to continue and shall use best efforts to end the failure or delay and ensure that the effects of such Force Majeure are minimized. 
 8.8. Beneficiaries. No person, other than Bioamber or DuPont and their permitted assignees hereunder, shall be deemed an intended beneficiary hereunder or have any right to enforce any obligation
of this Agreement. 
 8.9. Advice of Counsel. DuPont and Bioamber have each consulted counsel of their choice regarding this Agreement,
and each acknowledges and agrees that this Agreement shall not be deemed to have been drafted by one Party or another and will be construed accordingly. 
 8.10. No Trademark Rights. Except as provided herein, no right, express or implied, is granted by this Agreement to use in any manner the name “DuPont,” or any other trade name or
trademark of DuPont or its Affiliates or “Bioamber,” or any other trade name or trademark of Bioamber or its Affiliates in connection with performance of this Agreement. 
 8.11. Waiver. No waiver of any rights or consent under this Agreement shall be deemed effective unless contained in writing signed by the Party charged with such waiver or consent, and no waiver of
any breach or failure to perform shall be deemed a waiver of any future breach or failure to perform or any other right arising under this Agreement. 
 8.12. Headings. The section headings contained in this Agreement are included for convenience only and form no part of the agreement between the Parties 

  
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 IN WITNESS WHEREOF, the Parties have executed this Agreement. 

 

					
	Bioamber S.A.S.	 		 	E. I. du Pont de Nemours and Company
			
	 /s/ Jean-François Huc
	 		 	 /s/ Michael Saltzeberg

	Signature	 		 	Signature
			
	 Jean-François Huc
	 		 	 Michael Saltzeberg

	Printed Name	 		 	Printed Name
			
	 Director General
	 		 	 Business Director, Bio Specialties

	Title	 		 	Title

  
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 SCHEDULE A 
 [***] 

  
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 SCHEDULE B 
 TECHNICAL REPORTS 
 [***] 

  
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 SCHEDULE C 
 Form of Press Release 
 Bioamber and DuPont Collaborate on Derivatives of
Biobased Succinic Acid 
 Princeton, NJ – July 1, 2010 – Bioamber, a joint venture between DNP Green Technology and ARD, and
E. I. du Pont de Nemours and Company (DuPont), have announced a strategic collaboration in the field of biobased derivatives of succinic acid. Under the terms of the agreement, Bioamber has licensed certain DuPont technology and DuPont has a right
of first refusal to secure off-take from future commercial plants. 
 Bioamber, which recently commissioned the world’s first biobased
succinic acid plant, is actively developing technologies to transform biobased succinic acid into value added derivative products. “DuPont’s technology will accelerate our development program and shorten our time to market” stated
Jean-Francois Huc, President of DNP Green. “Our collaboration with DuPont will help ensure that we are first to market, and it could reduce the commercial risk associated with building large plants” he added. 

About Bioamber 
 Bioamber is the joint
venture between DNP Green Technology and Agro-industrie Recherches et Développements (ARD) that is dedicated to succinic acid. Bioamber possesses the only biobased succinic acid technology that has been proven at a commercial scale. Bioamber
recently commissioned the world’s first and only biobased succinic acid plant in Pomacle, France. For more information, visit www.bio-amber.com 
 About DuPont 
 To be completed 

About DNP Green Technology 
 DNP Green
Technology is a private US company that produces renewable chemicals. Through numerous scientific and business partnerships, DNP Green Technology has built an extensive IP portfolio and know-how covering the production, purification and uses of
biobased succinic acid and derivatives including modified PBS, a biodegradable polymer. DNP Green is actively developing other bio-based chemical platforms, leveraging industrial biotechnology and chemical synthesis to produce renewable chemicals
and bio-based materials. The company has offices in Princeton, N.J., Shanghai, China and Montreal, Canada. For more information, visit www.dnpgreen.com 
 About ARD 
 ARD (Agro-Industrie Recherches et Développements) is the R&D centre
of a large agro-industrial consortium based in Champagne-Ardenne, France. Member of the global-scale competitiveness cluster IAR (Industries and Agro-Resources), ARD adds value to and finds new outlets for agricultural crops. It develops innovative
and competitive bio-based molecules produced in bio-refineries. With its subsidiary SOLIANCE, specialized in the production and commercialization of cosmetics active ingredients, ARD has 25 years of experience in biomass fractionation, bio-based
chemistry, and industrial biotechnology. ARD and its affiliates employ over 130 people. For more information, please visit www.a-r-d.fr 
 For
More Information: 
 Mike Hartmann 
 VP
Corporate 
 DNP Green Technology 

E-mail: mike.hartmann@dnpgreen.com 
 Phone +1
(514) 844-8000 x120 

  
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 AMENDMENT TO THE LICENSE AGREEMENT ENTERED INTO BETWEEN E. I. DU PONT DE NEMOURS AND
COMPANY AND BIOAMBER S.A.S. AND ENTERED INTO FORCE AS OF JUNE 28, 2010 
  

This Amendment Agreement (the Amendment”) is made as of
February 18th, 2011 and is to be effective nunc
pro tunc, as of June 28, 2010, between E.I. du Pont de Nemours and Company (“DuPont”) and BioAmber S.A.S. (“BioAmber”). 
 WHEREAS DuPont and BioAmber entered into a License Agreement which entered into force on June 28, 2010 (the “Agreement”); 
 WHEREAS the parties desire to amend the Agreement as set forth herein; 
 NOW THEREFORE, DuPont and
BioAmber agree to amend the Agreement as follows: 
  

	1.	Sections 1.3 through 1.3.3, inclusive shall be replaced with the following: 

 1.3. “Confidential Information” means information disclosed by BioAmber hereunder when such is identified as the confidential information of BioAmber. Tangible embodiments of information shall
be deemed as “identified as confidential information” if clearly labeled as “Confidential” or “Proprietary” or with some other legend or marking indicating the confidential nature of the information. Information that is
disclosed verbally or by other non-tangible disclosure to DuPont shall be deemed as “identified as confidential information” if it is set forth by BioAmber in a writing clearly labeled “Confidential” or “Proprietary” or
with some other legend or marking indicating the confidential nature of the information, and the writing is delivered to DuPont within fifteen (15) days of said verbal/non-written disclosure. Information disclosed verbally or by other
non-written disclosure to DuPont shall be treated as Confidential Information during the fifteen (15) day period following such disclosure. 
 1.3.1. Information shall not be considered Confidential Information to the extent that any such information was (a) as of the date of disclosure to DuPont, known to DuPont and such knowledge can be
substantiated by reasonable documentation; (b) as of the date of disclosure to DuPont, disclosed in published literature or generally available to the public; (c) after the date of disclosure to DuPont, disclosed in published literature or
generally available to the public, other than by a breach by DuPont of the obligations of confidentiality and non-use set forth in this Agreement; (d) developed by DuPont independently from, and without exposure to, the information provided by
BioAmber; or (e) obtained by DuPont from a third party without binder of secrecy, provided that such third party had no obligation of confidentiality to BioAmber or any of its Affiliates relating to the Confidential Information. 

1.3.2. Information disclosed hereunder shall not be deemed to be within the exceptions merely set forth in Section 1.3.1 merely
because such information is embraced by more general knowledge in the public domain or in DuPont’s possession. In addition, no combination of features shall be deemed to be within the foregoing exceptions merely because individual features are
in the public domain or in DuPont’s possession, but only if the combination itself and its principles of operation are in the public domain or in DuPont’s possession. 
 1.3.3. For the purposes of Sections 1.3 through 1.3.3, inclusive, “information” includes, without limitation, all information relating to existing and potential inventions (whether or not
reduced to practice), discoveries, know-how, technologies, reports, data, results, observations, computer programs, patent applications, hypotheses, research directions, 

  
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developments, improvements, drawings, designs, specifications, methodologies, algorithms, formulas, protocols, strategic plans, business plans, business opportunities, draft and/or final
regulatory filings, customers, potential customers, suppliers, markets, contracts, prices, products, personnel, strategies, policies, systems, procedures, information, processes, research, applications, methods of manufacture and any other
information relating to BioAmber or any of its Affiliates. 
  

	2.	Section 1.8 shall be deleted in its entirety. 

  

	3.	Section 1.19 shall be deleted in its entirety. 

  

	4.	Section 1.20 shall be replaced with the following: 

 1.20. “Representatives” means the directors, officers, employees, agents, contractors, and/or Affiliates of DuPont to whom DuPont needs to disclose Confidential Information in connection with
the Parties’ performance under this Agreement. 
  

	5.	Section 6.6.2 shall be replaced with the following 

 6.6.2. Early termination of this Agreement shall not affect the rights and obligations of either Party incurred prior to termination. For example, obligations to make payments then due, and to maintain
Confidential Information in confidence, shall survive termination. Upon termination, DuPont shall return Confidential Information to BioAmber, or destroy it, as BioAmber shall instruct, and cease any use of BioAmber Confidential Information.

  

	6.	Article 4, Inclusive, shall be replaced with the following. 

  

	 	4.	CONFIDENTIAL INFORMATION 

4.1. Confidentiality and Non-Use. Confidential Information disclosed by BioAmber to DuPont shall be maintained in strict confidence
by DuPont and not used by DuPont for any purpose other than those authorized by this Agreement, for a fifteen (15) year period commencing from the Effective Date. Without limiting the foregoing, DuPont shall not use Confidential Information to
compete with or adversely affect the business or operations of BioAmber or its Affiliates or those doing business with them. DuPont may disclose Confidential Information to DuPont’s Representatives on a “need to know” basis, so long
as such Representatives agree to be bound by the obligations of confidentiality and non-use set forth in this Agreement or at least as strict as those set forth in this Agreement. DuPont shall be responsible for any breach of the obligations of
confidentiality and non-use set forth in this Agreement by any of DuPont’s Representatives. 
 4.2. Required
Disclosure. If DuPont is required by law to disclose any Confidential Information, DuPont shall (a) notify BioAmber of such requirement sufficiently in advance of such required disclosure in order to permit BioAmber to take steps to prevent
such disclosure, and (b) prior to any disclosure consult with and assist BioAmber in obtaining a protective order or other appropriate measure. In any event, DuPont will disclose only that portion of the Confidential Information which is
legally required and will use best efforts to assure that confidential treatment is accorded any Confidential Information so disclosed. 
 4.3. Equitable Relief. DuPont acknowledges that (a) the Confidential Information disclosed to DuPont by BioAmber is the trade secret information of BioAmber, (b) any breach of the
obligations of confidentiality and/or non-use set forth herein may cause irreparable harm to BioAmber, (c) in the event of such breach, damages alone will not be an adequate remedy to BioAmber, and (d) in addition to all other remedies to
which BioAmber may be entitled hereunder or otherwise, BioAmber may be entitled to injunctive relief, including specific performance, with respect to said obligations in any court of competent jurisdiction. 

  
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 4.4. Return of Confidential Information. Upon request by BioAmber at any time, DuPont
will promptly destroyed or return to BioAmber (at BioAmber’s sole option) the original and all copies of all BioAmber’s Confidential Information and will, upon request, certify in writing to BioAmber as to DuPont’s compliance with
this paragraph, except that DuPont may keep one (1) copy for archival purposes only. 
 4.5. No Grant of Rights.
Except as expressly set forth in this Agreement, DuPont shall not be deemed to receive any right or license under any Confidential Information disclosed by BioAmber pursuant to this Agreement. 

4.6. Press Release. Bioamber may not issue any press release, advertisement, or any other communication concerning this Agreement,
without the express written consent of DuPont. The Parties agree to release a press release of the form attached to this Agreement as Schedule C after the exact wording of such a press release has been agreed to by the Parties. The exact wording of
the press release shall be agreed to by the Parties within thirty (30) days of the Effective Date. The parties may issues future additional press releases as the Parties may agree. 

 

	7.	The Schedules A and B of the Agreement are deleted and replaced by the Schedules A and B attached hereto, which form an integral part hereof. 

 

	8.	The provisions of the Agreement not modified herein shall continue to be in force as stated in the Agreement. 

IN WITNESS WHEREOF, the parties hereto have signed this agreement as of the date first written above. 

 

									
	E. I. du Pont de Nemours and Company	 		 	BioAmber S.A.S.
					
	By:	 	 /s/ Michael Saltzeberg
	 		 	By:	 	 /s/ Jean-François Huc

	Signature	 		 	Jean-François Huc
		 		 	President
	 Michael Saltzeberg, Business Director, Bio Specialties
	 		 		 	
	Name and Title	 		 		 	

  
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 SCHEDULE A 
 [***] 

  
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 SCHEDULE B 
 TECHNICAL REPORTS 
 [***] 

  
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