Document:

EXHIBIT
      10.3

    

    FIFTH
      AMENDMENT TO ASSET PURCHASE AGREEMENT

    

    THIS
      FIFTH AMENDMENT
      to Asset
      Purchase Agreement is dated this 9th
      day of
      June, 2008, by and among Hunter Bates Mining Corporation (“Hunter
      Bates”),
      a
      Minnesota corporation and wholly-owned subsidiary of Wits Basin Precious
      Minerals Inc. (“Wits
      Basin”),
      a
      Minnesota corporation (as successor-in-interest to Wits Basin) (the
“Purchaser”),
      Central City Consolidated, Corp. d/b/a Central City Consolidated Mining Co.,
      a
      Colorado corporation, Hunter Gold Mining Inc., a Colorado corporation and George
      Otten, a Colorado resident (collectively, the “Sellers”
      and
      each
      individually, a“Seller”),
      and
      Hunter Gold Mining Corp., a British Columbia corporation (the “Covenantor”)
      (the
      Purchaser, Sellers and Covenantors are individually or collectively, as the
      case
      may be, a “Party”
or
      “Parties”).

     

    RECITALS: The
      Parties entered into an Asset Purchase Agreement dated on or about September
      20,
      2006, for the sale and purchase of assets, real estate and real estate mining
      claims described in such asset purchase agreement, which was amended by that
      certain First Amendment to Asset Purchase Agreement dated October 31, 2006,
      that
      Second Amendment to Asset Purchase Agreement dated as of March 1, 2007, that
      Third Amendment to Asset Purchase Agreement dated May 31, 2007 and that Fourth
      Amendment to Asset Purchase Agreement dated January 14, 2008 (collectively,
      “Purchase
      Agreement”);
      and
      the wish to amend the Purchase Agreement on the terms and conditions hereafter
      set forth. Capitalized terms used but not defined herein shall have the meanings
      ascribed to them in the Purchase Agreement. 

    

    AGREEMENT

     

    NOW,
      THEREFORE, in consideration of the foregoing and the mutual covenants and
      agreements set forth below, the Parties agree that the Purchase Agreement shall
      be revised as follows:

     

    1. Section
      3.2 is hereby deleted and replaced in its entirety with the following language:
      

     

    Purchase
      Price.
      In the
      event that Purchaser elects to proceed to closing, as and for the purchase
      price
      of the Purchased Assets, Purchaser agrees to pay and Sellers agree to accept
      the
      sum of Six Million Seven Hundred Fifty Thousand Canadian Dollars ($6,750,000.00
      CDN) plus Three Million Six Hundred Twenty Thousand (3,620,000) unregistered
      and
      restricted shares of the .01 par value common capital stock of Wits Basin
      Precious Minerals Inc., a Minnesota corporation (“Wits
      Basin”),
      payable as set out in Section 3.3 hereof (the “Purchase
      Price”).

     

    2. Section
      3.3(b)(ii) subsection (iv) is hereby deleted and replaced in its entirety with
      the following language: 

     

    (iv)
      Three Million Six Hundred Twenty Thousand (3,620,000) shares of the unregistered
      and restricted .01 par value common capital stock of Wits Basin. 

     

    3. Section
      3.3(b)(iv) is hereby deleted and replaced in its entirety with the following
      language:

     

    Seller
      shall deliver to Purchaser a fully-executed Undertaking Agreement in the form
      of
Exhibit
      I
      attached
      hereto and a fully-executed Shareholder Voting Agreement in the form of
Exhibit
      J
      attached
      hereto. 

     

    4. Sellers
      and Covenantor agree that the operations of the limited personal liability
      provisions under the Promissory Note attached hereto as Exhibit “C” shall be
      suspended until such time as the Sellers have delivered the certificate of
      an
      Officer of Hunter Gold Mining Corp. confirming that the covenants set forth
      in
      the Undertaking Agreement have be performed by the parties thereto.

     

    5. All
      references to Exhibits E and F are hereby deleted in their entirety.

     

    6. An
      execution copy of Exhibits C, D, I and J to the Purchase Agreement are hereby
      attached to this Fifth Amendment and shall replace any previous versions of
      such
      Exhibits. 

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    

     

    7. All
      references to “Central City Consolidated Mining Corp.” or “Central City
      Consolidated Mining Co.” or “Central City Mining Corp.” are hereby deleted in
      their entirety and replaced with “Central City Consolidated, Corp.”

     

    8. The
      first
      paragraph of the Purchase Agreement is hereby deleted and replaced in its
      entirety with the following language: 

     

    

    THIS
      ASSET PURCHASE AGREEMENT (this “Agreement”)
      is
      made and entered into as of this 20th day of September, 2006, by and among
      Wits
      Basin Precious Minerals Inc., a corporation organized under the laws of the
      State of Minnesota (the “Purchaser”),
      Central City Consolidated Corp. d/b/a Central City Consolidated Mining Co.,
      a
      corporation organized under the laws of the State of Colorado, Hunter Gold
      Mining Inc., a corporation organized under the laws of the state of Colorado
      and
      George Otten, a resident of Colorado, (collectively, the “Sellers”
and
      each individually as a “Seller”),
      and
      Hunter Gold Mining Corp., a corporation organized under the laws of the Province
      of British Columbia, (the “Covenantor”).
      

    

    9. The
      Parties acknowledge that Hunter Gold Mining Inc., a Colorado corporation, shall
      hereby be included in the definition of “Sellers”
and
      excluded from the definition of “Covenantors.”
All
      references to the term “Covenantors” shall include only Hunter Gold Mining
      Corp., a British Columbia corporation. All references to the plural term
“Covenantors” shall be deemed singular, mutatis
      mutandis.

     

    10. Section
      4.1.1 is hereby deleted in its entirety and replaced with the following
      language: 

     

    

     

    “Central
      City Consolidated Corp. and Hunter Gold Mining Inc. are corporations duly
      incorporated, validly existing and in good standing under the laws of their
      respective jurisdictions of incorporation. Central City Consolidated Corp.
      and
      Hunter Gold Mining Inc. have the requisite power to own, operate, use and/or
      lease the Purchased Assets, as applicable, and to conduct the operations of
      the
      Purchased Assets as presently being conducted by them and/or by the Covenantor,
      including any and all permits required by any public authority for such
      operations such as permits, or regulatory authorizations.”

     

    

     

    11. Section
      5.7 is hereby deleted in its entirety and replaced with the following language:
      

     

    “Shares
      Duly and Validly Issued.
      The
      3,620,000 shares of .01 par value common capital stock of Wits Basin
      constituting a portion of the Purchase Price shall have been duly and validly
      issued as fully paid and non-assessable, and in accordance with all applicable
      securities laws, as of the Closing Date.” 

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    

     

    12. Any
      notice or other documents given pursuant to the Purchase Agreement to Hunter
      Gold Mining Inc., as Seller, shall be sent to: Hunter Gold Mining Corp., P.O.
      Box 2460, Station “R”, Kelowna, British Columbia, Canada V1X 6A5, Attention:
      Dell Balfour, Facsimile: (250) 765-4420, with a copy to: Pushor Mitchell LLP,
      3rd Floor, 1665 Ellis Street, Kelowna, British Columbia, Canada V1W 4T7,
      Attention: E. Blair Forrest, Facsimile: (250) 762-9115. 

     

    13. Section
      8.10 of the Purchase Agreement is deleted in its entirety and replaced with
      the
      following:

     

    “Purchaser
      reserves the right hereunder to assign its right(s) to one or more affiliated
      parties prior to closing, it being understood that Purchaser may create one
      or
      more new entities which may consummate the Contemplated Transactions. In the
      event that the Purchaser assigns it right(s) hereunder any such affiliated
      party
      or parties, then (i) Purchaser shall also make, or shall cause such assignee(s)
      to make, in respect of such assignee(s), the representations and warranties
      set
      forth in sections 5.1 to 5.6 (inclusive) of the Purchase Agreement, (ii)
      Purchaser shall cause such assignee(s) to agree to be bound by all of the
      Purchaser’s covenants and obligations under the Purchase Agreement except for
      those which, by their nature, are intended to be performed solely by the
      Purchaser notwithstanding any assignment of the Purchaser’s rights under the
      Purchase Agreement, (iii) both the Purchaser and each such assignee shall
      deliver a certificate of an officer thereof for the purposes of section 9.1
      of
      the Purchase Agreement, and (iv) the opinions set forth in the Purchaser
      Counsel’s Legal Opinion (as defined in section 9.4 hereof) shall extend, to the
      extent applicable, to both the Purchaser and its assignee(s).” 

     

    

     

    14. To
      each
      of the Sellers and the Covenantor, Hunter Bates hereby makes the representations
      and warranties set forth in sections 5.1 to 5.6 (inclusive) of the Purchase
      Agreement as though the term “Purchaser” set forth therein refers to Hunter
      Bates and with the exception that the representation set forth in section 5.5
      of
      the Purchase Agreement shall be deemed to include the words “Except for the
      consent of “Wits Basin,” at the beginning of such section. Hunter Bates further
      agrees to be bound by all of the covenants and obligations of the Purchaser
      except for those covenants and obligations which, by their nature, are intended
      to be performed by Wits Basin notwithstanding the assignment of Wits Basin’s
      rights under the Purchase Agreement to Hunter Bates. 

     

    15. Wits
      Basin hereby confirms that it has consented to the consummation by Hunter Bates
      of the “Contemplated Transactions” (as defined in the Purchase Agreement) and to
      its execution of any documents incidental thereto.

     

    16. The
      parties hereto agree that in the event the tax advisors to Hunter Gold Mining
      Inc. and Hunter Gold Mining Corp. identify and recommend an alternate structure
      for the delivery of the Purchase Price including, but not limited to, the
      distribution and documentation of the Purchase Price in the name of one or
      more
      alternate parties, and/or recommend an alteration to the content of the
      Allocation Schedule, then each of the parties hereto agrees to take all
      reasonable steps to record and effect the necessary changes to the Purchase
      Agreement and the documents ancillary thereto to implement such recommendation;
      provided, however, that Sellers and Covenantor shall reimburse Purchaser for
      all
      reasonable expenses incurred in the course of effecting such change.
      Notwithstanding the foregoing, Purchaser shall not be obligated to participate
      in effecting the aforementioned changes if, in the reasonable opinion of legal
      counsel to the Purchaser, there is a reasonable risk of adverse tax, accounting
      or securities law consequences to the Purchaser in connection with the
      implementation of such changes. The parties further agree that any references
      to
      a deemed value for the 3,620,000 shares of common capital stock of Wits Basin,
      which comprise a portion of the Purchase Price under the Purchase Agreement,
      contained in the Purchase Agreement or in any of the transaction documents
      ancillary to the Purchase Agreement shall not be binding on the parties thereto
      in conjunction with any valuation of the Purchase Price for taxation purposes
      and the Sellers and Covenantor shall be at liberty to employ any reasonable
      method of valuation that is recommended by the tax advisors to Hunter Gold
      Mining Inc. and Hunter Gold Mining Corp.

     

    17. Clause
      12.4(e) of the Purchase Agreement is hereby added with the following
      language:

     

    “(e)
      any
      costs not otherwise falling within the scope of subsections 12.4(a) - (e),
      inclusive, which are reasonably incurred by or on behalf of the Beneficiary
      (as
      defined in the Deed of Trust), following enforcement by the Beneficiary of
      its
      remedies under the Deed of Trust, in effecting the remediation and/or
      rehabilitation of the Acquired Real Property in respect of any activities of
      the
      Purchaser (or its related party successors) thereon where such activities (i)
      contravene any Environmental Law (regardless of whether such contravention
      is
      enforced against the Purchaser or its successors) and (ii) take place after
      January 15, 2005 and prior to the earlier of (a) time of repossession of the
      Acquired Real Property by the Beneficiary or (b) transfer of the Acquired Real
      Property to a third party unrelated to the Purchaser; provided, however, that
      the maximum amount of the Purchaser's liability under this subsection 12.4(e)
      shall be $4,750,000 CDN.”

     

    18. The
      Allocation Schedule set forth in Section 3.8 is hereby deleted in its entirety
      and replaced with the allocation schedule attached hereto as Exhibit
      K.
      

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    

     

    19. The
      Parties agree that the following amounts, when advanced by the Purchasers on
      behalf of the Sellers and/or the Covenantors, shall be credited against the
      amount due under the Promissory Note attached hereto and to the Purchase
      Agreement as Exhibit “C”, and Sellers shall deliver a receipt to the Purchasers
      upon payment by the Purchasers of such amounts:

     

    
      	 	
              (i)

            	
              $15,000.00
                to Pushor Mitchell LLP in respect of past legal fees of the Covenantor
                (paid),

            

    

     

    
      	 	
              (ii)

            	
              $5,000.00
                to Dill Dill Carr Stonbraker and Hutchings, PC in respect of the
                closing
                legal costs of Hunter Gold Mining Inc.
                (paid),

            

    

     

    
      	 	
              (iii)

            	
              $7,500.00
                to Pushor Mitchell LLP for the closing legal costs of the Covenantor
                (pending),

            

    

     

    
      	 	
              (iv)

            	
              $3,467.16
                to First American Heritage Title Company for the Sellers’ closing costs as
                per the Sellers Closing Statement
                (pending),

            

    

     

    
      	 	
              (v)

            	
              $1,376.60
                for the Sellers’ 2008 personal property taxes
                (pending)

            

    

     

    for
      a
      total of $32,343.76.

     

    20. At
      the
      end of the first sentence of Article 2 of the Purchase Agreement, the words
      “(Assumed
      Liabilities”)”
is
      hereby added. 

     

    21. All
      references to “Purchaser Losses” in Sections 6.4(d) and (e) of the Purchase
      Agreement are hereby replaced with “Purchaser Environmental Losses.”

     

    22. The
      term
“Purchaser Losses” in Section 12.1 of the Purchase Agreement is hereby replaced
      with the following language: 

     

    “loss,
      liability, expense (including without limitation reasonable expenses of
      investigation and reasonable attorneys’ fees and expenses in connection with any
      action, suit or proceeding brought against the Purchaser (or its related party
      successors)) or Damages suffered or incurred by the Purchaser (or its related
      party successors) (the “Purchaser
      Losses”)”
      

     

    23. Except
      as
      provided for above, all the terms and conditions of the Purchase Agreement
      shall
      remain in full force and effect. This Fifth Amendment may be executed in
      counterparts. A facsimile signature shall be deemed an original.

     

    

     

    Signature
      Page Follows

     

    
      
         

      

      
         

        
          

        

      

      
         

      

    

    IN
      WITNESS WHEREOF, the parties hereto have caused this Fifth Amendment to be
      duly
      executed and delivered, all on and as of the date first written
      above.

     

    

     

    
      	 	 
	
               

              HUNTER
                BATES MINING CORPORATION 

              a
                Minnesota corporation

              By:
                /s/
                Mark D. Dacko

              Its:
                CFO

            	 
	
               

              CENTRAL
                CITY CONSOLIDATED, CORP. 

              a
                Colorado corporation

              By:/s/
                George E. Otten 

              Its:
                President

            	
               

              GEORGE
                OTTEN, a resident of Colorado

               

               

              /s/
                George E. Otten

            
	
               

              HUNTER
                GOLD MINING CORP.

              a
                British Columbia corporation

              By:
                /s/
                George E. Otten 

              Its:President

            	
               

              HUNTER
                GOLD MINING INC. 

              a
                Colorado corporation

              By:
                /s/
                George E. Otten 

              Its:
                President

            

    

    

    

    The
      foregoing is consented to by and joined solely with respect to Section 5.7
      of
      the Purchase Agreement, as amended by this Fifth Amendment: 

     

    WITS
      BASIN PRECIOUS MINERALS INC. 

     

    a
      Minnesota corporation

     

    

     

    By:
      /s/
      Mark D. Dacko

    Its:
      CFOExhibit 10.1
    

    
      EMPLOYMENT AGREEMENT
    

    
      THIS EMPLOYMENT AGREEMENT (the "Agreement"),
      dated as of September 30,  2009, is hereby entered into in the State of
      Maryland by and between SUCAMPO PHARMACEUTICALS, INC., a Delaware
      corporation (the "Company"), and JAMES J. EGAN ("Executive").
    

    
      WHEREAS, Executive has been employed by the Company since
      September 14, 2009 (the “Effective Date”);
    

    
      WHEREAS, Executive possesses certain skills, experience or
      expertise which will be of use to the Company;
    

    
      WHEREAS, the parties acknowledge that Executive's abilities and
      services are unique and will significantly enhance the business
      prospects of the Company; and
    

    
      WHEREAS, in light of the foregoing, the Company desires to
      continue to employ Chief Operating Officer and Executive desires to
      remain in such employment.
    

    
      NOW, THEREFORE, in consideration of the promises and the mutual
      covenants and agreements herein contained, the Company and Executive
      hereby agree as follows:
    

    
      
        

        

      

      
        

        

        
          

        

      

      
        

        

      

    

    
      Article 1.   Employment Agreement
    

    
      1.1                Employment
      and Duties
    

    
                         The Company offers and Executive hereby accepts
      employment with the Company for the Term (as hereinafter defined) as its
      Chief Operating Officer,  and in connection therewith, to perform such
      duties as Executive shall reasonably be assigned by Executive's
      supervisor and/or by the Company's Board of Directors.  Executive hereby
      warrants and represents that Executive has no contractual commitments or
      other obligations to third parties inconsistent with Executive's
      acceptance of this employment and performance of the obligations set
      forth in this Agreement.  Executive shall perform such duties and carry
      out Executive's responsibilities hereunder faithfully and to the best of
      Executive's ability, and shall devote Executive's full business time and
      best efforts to the business and affairs of the Company during normal
      business hours (exclusive of periods of vacation, sickness, disability,
      or other leaves to which Executive is entitled).  Executive will perform
      all of Executive's responsibilities in compliance with all applicable
      laws and will ensure that the operations that Executive manages are in
      compliance with all applicable laws.  
    

    
      Article 2.   Employment Term
    

    
      2.1                Term
    

    
      The term of Executive's employment hereunder (the "Term")
      shall be deemed to commence on the Effective Date and shall end on the
      second anniversary of the Effective Date, unless sooner terminated as
      hereinafter provided; provided, however, that the Term
      shall be automatically renewed and extended for an additional period of
      one (1) year on each anniversary thereafter unless either party gives a
      Notice of Termination (as defined below) to the other party at least
      sixty (60) days prior to such anniversary.  
    

    
      
        

        

      

      
        
          2
        

        
          

        

      

      
        

        

      

    

    
      2.2                Survival
      on Merger or Acquisition
    

    
      In the event the Company is acquired during the Term, or is the
      non-surviving party in a merger, or sells all or substantially all of
      its assets, this Agreement shall not automatically be terminated, and
      the Company agrees to use its best efforts to ensure that the transferee
      or surviving company shall assume and be bound by the provisions of this
      Agreement.
    

    
      Article 3.   Compensation and Benefits
    

    
      3.1                Compensation
    

    
      (a)                Base
      Salary.  The Company shall pay Executive a salary at an annual rate
      that is not less than two hundred and sixty-five thousand and no/100
      dollars ($265,000.00), to be paid in bi-weekly installments, in arrears
      (the "Base Salary").  Thereafter, the Base Salary will be
      reviewed by the Compensation Committee of the Board of Directors
      ("Compensation Committee") at least annually, and the
      Committee's recommendation shall be reviewed and approved by the Board
      of Directors.  The Base Salary may, in the sole discretion of the Board
      of Directors, be increased, but not decreased (unless mutually agreed by
      Executive and the Company).  
    

    
      (b)                Stock
      Compensation.  At least annually for the Term of this Agreement,
      Executive shall be eligible for consideration to receive restricted
      stock grants, incentive stock options or other awards in accordance with
      the 2006 Stock Incentive Plan.  Recommendations concerning the decision
      to make an award pursuant to that Plan and the amount of any award are
      entirely discretionary and shall be made initially by the Compensation
      Committee, subject to review and approval by the Board of Directors.  In
      the event that, during the Term (i) the Company is acquired or is the
      non-surviving party in a merger, or (ii) the Company sells all or
      substantially all of its assets, or (iii) in the event of the death of
      Executive, all unvested restricted stock awards and incentive stock
      options having previously been awarded to Executive shall immediately
      vest and may be exercised in accordance with the terms of the Plan and
      the Executive's grant award.  
    

    
      
        

        

      

      
        
          3
        

        
          

        

      

      
        

        

      

    

    
      (c)                Bonuses.  Executive
      shall be eligible to receive an annual bonus award in recognition of
      Executive's contributions to the success of the Company pursuant to the
      Company's management incentive bonus program as it may be amended or
      modified from time to time.  Recommendations concerning the decision to
      make an award and the amount of any award are entirely discretionary and
      shall be made initially by the Compensation Committee, subject to review
      and approval by the Board of Directors.
    

    
      (d)                Withholding
      Taxes.  All compensation due to Executive shall be paid subject to
      withholding by the Company to ensure compliance with all applicable laws
      and regulations.
    

    
      3.2                Participation
      in Benefit Plans
    

    
      Executive shall be entitled to participate in all employee benefit plans
      or programs of the Company offered to other employees to the extent that
      Executive's position, tenure, salary, and other qualifications make
      Executive eligible to participate in accordance with the terms of such
      plans.  The Company does not guarantee the continuance of any particular
      employee benefit plan or program during the Term, and Executive's
      participation in any such plan or program shall be subject to all terms,
      provisions, rules and regulations applicable thereto.    
    

    
      
        

        

      

      
        
          4
        

        
          

        

      

      
        

        

      

    

    
      3.3                Expenses
    

    
      The Company will pay or reimburse Executive for all reasonable and
      necessary out-of-pocket expenses incurred by Executive in the
      performance of Executive's duties under this Agreement.  Executive shall
      provide to the Company detailed and accurate records of such expenses
      for which payment or reimbursement is sought, and Company payments shall
      be in accordance with the regular policies and procedures maintained by
      the Company from time to time.
    

    
      3.4                Professional
      Organizations
    

    
      During the Term, Executive shall be reimbursed by the Company for the
      annual dues payable for membership in professional societies associated
      with subject matter related to the Company's interests.  New memberships
      for which reimbursement will be sought shall be approved by the Company
      in advance.
    

    
      3.5                Parking
    

    
      During the Term, the Company shall either provide parking for
      Executive's automobile at the Company's expense or reimburse Executive
      for such expense.
    

    
      Article 4.   Termination of Employment
    

    
      4.1                Definitions
    

    
      As used in Article 4 of this Agreement, the following terms shall have
      the meaning set forth for each below:
    

    
      
        

        

      

      
        
          5
        

        
          

        

      

      
        

        

      

    

    
      (a)                "Benefit
      Period" shall mean the six (6) month period commencing on the Date
      of Termination which occurs in connection with a termination of
      employment described in the first sentence of Section 4.4(a), or a
      period ending when Executive becomes eligible for group medical benefits
      coverage from another source, whichever is shorter.
    

    
      (b)                "Cause"
      shall mean any of the following:
    

    
      (i)                the gross neglect or willful failure or refusal of
      Executive to perform Executive's duties hereunder (other than as a
      result of Executive's death or Disability);
    

    
      (ii)               perpetration of an intentional and knowing fraud
      against or affecting the Company or any customer, supplier, client,
      agent or employee thereof;
    

    
      (iii)              any willful or intentional act that could reasonably
      be expected to injure the reputation, financial condition, business or
      business relationships of the Company or Executive's reputation or
      business relationships;
    

    
      (iv)               conviction (including conviction on a nolo
      contendere plea) of a felony or any crime involving fraud,
      dishonesty or moral turpitude;
    

    
      (v)                the material breach by Executive of this Agreement
      (including, without limitation, the Employment Covenants set forth in
      Article 5 of this Agreement); or
    

    
      
        

        

      

      
        
          6
        

        
          

        

      

      
        

        

      

    

    
      (vi)               the failure or continued refusal to carry out the
      directives of Executive's supervisor or the Board of Directors that are
      consistent with Executive's duties and responsibilities under this
      Agreement which is not cured within thirty (30) days after receipt of
      written notice from the Company specifying the nature of such failure or
      refusal; provided, however, that Cause shall not exist if
      such refusal arises from Executive's reasonable, good faith belief that
      such failure or refusal is required by law.
    

    
      (c)                "Date
      of Termination" shall mean the date specified in the Notice of
      Termination (as hereinafter defined) (except in the case of Executive's
      death, in which case the Date of Termination shall be the date of
      death); provided, however, that if Executive's employment
      is terminated by the Company other than for Cause, the date specified in
      the Notice of Termination shall be at least thirty (30) days from the
      date the Notice of Termination is given to Executive.
    

    
      (d)                "Notice
      of Termination" shall mean a written notice from the Company to
      Executive that indicates Section 2 or the specific provision of Section
      4 of this Agreement relied upon as the reason for such termination or
      nonrenewal, the Date of Termination, and, in the case of termination or
      non-renewal by the Company for Cause, in reasonable detail, the facts
      and circumstances claimed to provide a basis for termination or
      nonrenewal.  
    

    
      (e)                "Good
      Reason" shall mean:
    

    
      (i)                Company effects a material diminution of Executive's
      position, authority or duties;
    

    
      
        

        

      

      
        
          7
        

        
          

        

      

      
        

        

      

    

    
      (ii)               any requirement that Executive, without his/her
      consent, move his/her regular office to a location more than fifty (50)
      miles from Company's executive offices;
    

    
      (iii)              the material failure by Company, or its successor, if
      any, to pay compensation or provide benefits or perquisites to Executive
      as and when required by the terms of this Agreement; or
    

    
      (iv)               any material breach by Company of this Agreement.
    

    
                         The Executive shall have Good Reason to terminate
      Executive's employment if (i) within twenty-one (21) days following
      Executive's actual knowledge of the event which Executive determines
      constitutes Good Reason, Executive notifies the Company in writing that
      Executive has determined a Good Reason exists and specifies the event
      creating Good Reason, and (ii) following receipt of such notice, the
      Company fails to remedy such event within twenty-one (21) days.  If
      either condition is not met, Executive shall not have a Good Reason to
      terminate Executive's employment.
    

    
      (f)                     "Change
      in Control" shall mean:
    

    
      (i)                 the acquisition by any person of beneficial
      ownership of fifty percent (50%) or more of the outstanding shares of
      the Company's voting securities; or
    

    
      (ii)                the Company is the non-surviving party in a merger;
      or
    

    
      
        

        

      

      
        
          8
        

        
          

        

      

      
        

        

      

    

    
      (iii)               the Company sells all or substantially all of its
      assets; provided, however, that no "Change in Control" shall be deemed
      to have occurred merely as the result of a refinancing by the Company or
      as a result of the Company's insolvency or the appointment of a
      conservator; or
    

    
      (iv)                the Compensation Committee of the Company, in its
      sole and absolute discretion determines that there has been a sufficient
      change in the share ownership or ownership of the voting power of the
      Company's voting securities to constitute a change of effective
      ownership or control of the Company.
    

    
      4.2                Termination
      Upon Death or Disability
    

    
      This Agreement, and Executive's employment hereunder, shall terminate
      automatically and without the necessity of any action on the part of the
      Company upon the death of Executive.  In addition, if at any time during
      the Term, Executive shall become physically or mentally disabled (as
      determined by an independent physician competent to assess the condition
      at issue), whether totally or partially, so that Executive is unable
      substantially to perform Executive's duties and services hereunder, with
      or without reasonable accommodation, for either (i) a period of sixty
      (60) consecutive calendar days, or (ii) ninety (90) consecutive or
      non-consecutive calendar days during any consecutive five (5) month
      period (the "Disability Date"), the Company may terminate this Agreement
      and Executive's employment hereunder by written notice to Executive
      after the Disability Date (but before Executive has recovered from such
      disability).
    

    
      
        

        

      

      
        
          9
        

        
          

        

      

      
        

        

      

    

    
      4.3                Company's
      and Executive's Right to Terminate
    

    
      This Agreement and Executive's employment hereunder may be terminated at
      any time by the Company for Cause or, if without Cause, upon thirty (30)
      days prior written notice to Executive.  In the event the Company should
      give Executive notice of termination without Cause, the Company may, at
      its option, elect to provide Executive with thirty (30) days' salary in
      lieu of Executive's continued active employment during the notice
      period.  This Agreement and Executive's employment hereunder may be
      terminated by Executive at any time for Good Reason and, if without Good
      Reason, upon thirty (30) days prior written notice to the Company.
    

    
      4.4                Compensation
      Upon Termination
    

    
      (a)                          Severance.  In
      the event the Company terminates Executive’s employment without Cause or
      pursuant to Section 4.2 due to the disability of Executive, or elects
      not to renew this Agreement under circumstances where Executive is
      willing and able to execute a new agreement providing terms and
      conditions substantially similar to those in this Agreement, or in the
      event Executive terminates employment for Good Reason, Executive shall
      be entitled to receive: (i) Executive's Base Salary through the Date of
      Termination, (ii) reimbursement of any COBRA continuation premium
      payments made by Executive for the Benefit Period, and (iii) a lump sum
      severance payment equal to six (6) months of Executive's then current
      Base Salary to be made not later than ten (10) business days following
      the expiration of the revocation period in Executive's Release (as
      provided in Section 4.4(c) below) without any revocation having
      occurred.  Notwithstanding the foregoing, the Company shall, to the
      extent necessary and only to the extent necessary, modify the timing of
      delivery of severance benefits to Executive if the Company reasonably
      determines that the timing would subject the severance benefits to any
      additional tax or interest assessed under Section 409A of the Internal
      Revenue Code.  In such event, the payments will be made as soon as
      practicable without causing the severance benefits to trigger such
      additional tax or interest under Section 409A of the Internal Revenue
      Code.  In the event this Agreement is terminated (or not renewed) for
      any reason other than by the Company without Cause or pursuant to
      Section 4.2 due to the disability of Executive or by Executive for Good
      Reason, Executive shall not be entitled to the continuation of any
      compensation, bonuses or benefits provided hereunder, or any other
      payments following the Date of Termination, other than Base Salary
      earned through such Date of Termination.  
    

    
      
        

        

      

      
        
          10
        

        
          

        

      

      
        

        

      

    

    
      (b)                          Change
      in Control. In the event that Executive is terminated other than for
      "Cause" within eighteen (18) months following the occurrence of a
      "Change in Control" of the Company, then Executive shall be entitled to
      a severance payment in an amount that is two (2) times the amount
      specified in Section 4.4(a), clause (iii) above (the "Change in Control
      Severance Payment").  In the event that Executive shall become entitled
      to a Change in Control Severance Payment as provided herein, the Company
      shall cause its independent auditors promptly to review, at the
      Company's sole expense, the applicability to those payments of Sections
      280G and 4999 of the Internal Revenue Code of 1986, as amended (the
      "Code").  If the auditors determine that any payment of the Change in
      Control Severance Payment would be subject to the excise tax imposed by
      Section 4999 of the Code or any interest or penalties with respect to
      such excise tax, then such payment owed to Executive shall be reduced by
      an amount calculated to provide to Executive the maximum Change in
      Control Severance Payment which will not trigger application of Sections
      280G and 4999 of the Code.
    

    
      
        

        

      

      
        
          11
        

        
          

        

      

      
        

        

      

    

    
      (c)                Release.  Anything
      to the contrary contained herein notwithstanding, as a condition to
      Executive receiving severance benefits to be paid pursuant to this
      Section 4.4, Executive shall execute and deliver to the Company a
      general release in the form attached hereto as Exhibit A.  The Company
      shall have no obligation to provide any severance benefits to Executive
      until it has received the general release from Executive and any
      revocation or rescission period applicable to the Release shall have
      expired without revocation or rescission.
    

    
      Article 5.   Employment Covenants
    

    
      5.1       Definitions  
    

    
      As used in this Article 5 of the Agreement, the following terms shall
      have the meaning set forth for each below:
    

    
      (a)                          "Affiliate"
      shall mean a person or entity that directly, or indirectly through one
      or more intermediaries, controls or is controlled by, or under common
      control with another person or entity, including current and former
      directors and officers of such an entity.
    

    
      
        

        

      

      
        
          12
        

        
          

        

      

      
        

        

      

    

    
      (b)                          "Confidential
      Information" shall mean all confidential and proprietary information
      of the Company, its Predecessors and Affiliates, whether in written,
      oral, electronic or other form, including but not limited to trade
      secrets; technical, scientific or business information; processes; works
      of authorship; Inventions; discoveries; developments; systems; chemical
      compounds; computer programs; code; algorithms; formulae; methods;
      ideas; test data; know how; functional and technical specifications;
      designs; drawings; passwords; analyses; business plans; information
      regarding actual or demonstrably anticipated business, research or
      development; marketing, sales and pricing strategies; and information
      regarding the Company's current and prospective consultants, customers,
      licensors, licensees, investors and personnel, including their names,
      addresses, duties and other personal characteristics.  Confidential
      Information does not include information that (i) is in the public
      domain, other than as a result of an act of misappropriation or breach
      of an obligation of confidentiality by any person; (ii) Executive can
      verify by written records kept in the ordinary course of business was in
      Executive's lawful possession prior to its disclosure to Executive;
      (iii) is received by Executive from a third party without a breach of an
      obligation of confidentiality owed by the third party to the Company and
      without the requirement that Executive keep such information
      confidential; or (iv) Executive is required to disclose by applicable
      law, regulation or order of a governmental agency or a court of
      competent jurisdiction.  If Executive is required to make disclosure
      pursuant to clause (iv) of the preceding sentence as a result of the
      issuance of a court order or other government process, Executive shall
      (a) promptly, but in no event more than 72 hours after learning of such
      court order or other government process, notify, pursuant to Section 6.1
      below, the Company; (b) at the Company's expense, take all reasonable
      necessary steps requested by the Company to defend against the
      enforcement of such court order or other government process, and permit
      the Company to intervene and participate with counsel of its choice in
      any proceeding relating to the enforcement thereof; and (c) if such
      compelled disclosure is required, Executive shall disclose only that
      portion of the Confidential Information that is necessary to meet the
      minimum legal requirement imposed on Executive.
    

    
      
        

        

      

      
        
          13
        

        
          

        

      

      
        

        

      

    

    
      (c)                          "Executive
      Work Product" shall mean all Confidential Information and Inventions
      conceived of, created, developed or prepared by Executive (whether
      individually or jointly with others) before or during Executive's
      employment with the Company, during or outside of working hours, which
      relate in any manner to the actual or demonstrably anticipated business,
      research or development of the Company, or result from or are suggested
      by any task assigned to Executive or any work performed by Executive for
      or on behalf of the Company or any of its Affiliates.  
    

    
      (d)                          "Invention"
      shall mean any apparatus, biological processes, cell line, chemical
      compound, creation, data, development, design, discovery, formula, idea,
      improvement, innovation, know-how, laboratory notebook, manuscript,
      process or technique, whether or not patentable or protectable by
      copyright, or other intellectual property in any form.
    

    
      (e)                          "Predecessor"
      shall mean an entity, the major portion of the business and assets of
      which was acquired by another entity in a single transaction or in a
      series of related transactions.  
    

    
      (f)                          "Trade
      Secrets," as used in this Agreement, will be given its broadest
      possible interpretation under the law applicable to this Agreement.
    

    
      
        

        

      

      
        
          14
        

        
          

        

      

      
        

        

      

    

    
      5.2                Nondisclosure
      and Nonuse  
    

    
      Executive acknowledges that prior to and during Executive's employment
      with the Company, Executive had and will have occasion to create,
      produce, obtain, gain access to or otherwise acquire, whether
      individually or jointly with others, Confidential
      Information.  Accordingly, during the term of Executive's employment
      with the Company and at all times thereafter, Executive shall keep
      secret and shall not, except for the Company's benefit, disclose or
      otherwise make available to any person or entity or use, reproduce or
      commercialize, any Confidential Information, unless specifically
      authorized in advance by the Company in writing.
    

    
      5.3                Other
      Confidentiality Obligations  
    

    
      Executive acknowledges that the Company may, from time to time, have
      agreements with other persons or entities or with the U.S. Government or
      governments of other countries, or agencies thereof, which impose
      confidentiality obligations or other restrictions on the
      Company.  Executive hereby agrees to be bound by all such obligations
      and restrictions and shall take all actions necessary to discharge the
      obligations of the Company thereunder, including, without limitation,
      signing any confidentiality or other agreements required by such third
      parties.
    

    
      5.4                Return
      of Confidential Information  
    

    
      At any time during Executive's employment with the Company, upon the
      Company's request, and in the event of Executive's termination of
      employment with the Company for any reason whatsoever, Executive shall
      immediately surrender and deliver to the Company all records, materials,
      notes, equipment, drawings, documents and data of any nature or medium,
      and all copies thereof, relating to any Confidential Information
      (collectively the "the Company Materials") which is in Executive's
      possession or under Executive's control.  Executive shall not remove any
      of the Company Materials from the Company's business premises or deliver
      any of the Company Materials to any person or entity outside of the
      Company, except as required in connection with Executive's duties of
      employment.  In the event of the termination of Executive's employment
      for any reason whatsoever, Executive shall promptly sign and deliver to
      the Company a Termination Certificate in the form of Exhibit B attached
      hereto.  
    

    
      
        

        

      

      
        
          15
        

        
          

        

      

      
        

        

      

    

    
      5.5                Confidential
      Information of Others  
    

    
      Executive represents that Executive's performance of all the terms of
      this Agreement and Executive's employment with the Company do not and
      will not breach any agreement to keep in confidence proprietary
      information, knowledge or data with regard to which Executive has
      obligations of confidentiality or nonuse, and Executive shall not
      disclose to the Company or cause the Company to use any such
      confidential proprietary information, knowledge or data belonging to any
      previous employer of Executive or other person.  Executive represents
      that Executive has not brought and will not bring to the Company or use
      at the Company any confidential materials or documents of any former
      employer or other person that are not generally available to the public,
      unless express written authorization for their possession and use has
      been obtained from such former employer or other person.  Executive
      agrees not to enter into any agreement, whether written or oral, that
      conflicts with these obligations.
    

    
      5.6                Other
      Obligations
    

    
      The terms of this Section 5 are in addition to, and not in lieu of, any
      statutory or other contractual or legal obligation to which Executive
      may be subject relating to the protection of Confidential Information.
    

    
      
        

        

      

      
        
          16
        

        
          

        

      

      
        

        

      

    

    
      5.7                Assignment
      of Confidential Information and Inventions; Works Made for Hire
    

    
      Executive hereby assigns to the Company all right, title and interest in
      all intellectual property, including any patent applications, trade
      secrets, know how, copyrights, software, or trademarks associated with
      the Executive Work Product and Confidential Information.  Executive
      hereby acknowledges and agrees that all Executive Work Product subject
      to copyright protection constitutes "work made for hire" under United
      States copyright laws (17 U.S.C. § 101) and is owned exclusively by the
      Company.  To the extent that title to any Executive Work Product subject
      to copyright protection does not constitute a "work for hire," and to
      the extent title to any other Executive Work Product does not, by
      operation of law or otherwise, vest in the Company, all right, title,
      and interest therein, including, without limitation, all copyrights,
      patents and trade secrets, and all copyrightable or patentable subject
      matter, are hereby irrevocably assigned to the Company.  Executive shall
      promptly disclose to the Company in writing all Executive Work
      Product.  Executive shall, without any additional compensation, execute
      and deliver all documents or instruments and give the Company all
      assistance it requires to transfer all right, title, and interest in any
      Executive Work Product to the Company; to vest in the Company good,
      valid and marketable title to such Executive Work Product; to perfect,
      by registration or otherwise, trademark, copyright and patent protection
      of the Company with respect to such Executive Work Product; and
      otherwise to protect the Company's trade secret and proprietary interest
      in such Executive Work Product.  Executive hereby irrevocably designates
      and appoints the Company and its duly authorized officers and agents as
      Executive's agents and attorneys-in-fact to act for and on Executive's
      behalf, and to execute and file any documents and to do all other
      lawfully permitted acts to further the purposes of this Section 5.7 with
      the same legal force and effect as if executed by Executive.
    

    
      
        

        

      

      
        
          17
        

        
          

        

      

      
        

        

      

    

    
      5.8                Representations
    

    
      Executive represents that, to the best of his or her knowledge, none of
      the Inventions will violate or infringe upon any right, patent,
      copyright, trademark or right of privacy, or constitute libel or slander
      against or violate any other rights of any person, firm or corporation,
      and that Executive will not knowingly create any Invention which causes
      any such violation.
    

    
      5.9                Inventions,
      Intellectual Property and Equipment Not Transferred  
    

    
      Executive has set forth on Exhibit C attached hereto a complete list and
      brief description of all Inventions, intellectual property and equipment
      located at the Company which is owned directly or indirectly by
      Executive and which shall not be transferred to the Company pursuant to
      this Agreement.  Except as so listed, Executive agrees that he or she
      will not assert any rights under any intellectual property as having
      been made or acquired by Executive prior to being employed by the
      Company.  The Company may, at its discretion, require detailed
      disclosures and materials demonstrating ownership of the intellectual
      property so listed.
    

    
      5.10          Exclusivity
      of Employment
    

    
      During the Term, and without prior approval of the Board of Directors,
      Executive shall not directly or indirectly engage in any activity
      competitive with or adverse to the Company's business or welfare or
      render a material level of services of a business, professional or
      commercial nature to any other person or firm, whether for compensation
      or otherwise.  
    

    
      5.11               Covenant
      Not to Compete
    

    
      Executive agrees to be bound and abide by the following covenant not to
      compete:
    

    
      
        

        

      

      
        
          18
        

        
          

        

      

      
        

        

      

    

    
      (a)                Term
      and Scope.  During Executive's employment with the Company and for a
      period of twelve (12) months after the Term, Executive will not render
      to any Conflicting Organization (as hereinafter defined), services,
      directly or indirectly, anywhere in the world in connection with any
      Conflicting Product (as hereunder defined), except that Executive may
      accept employment with a Conflicting Organization whose business is
      diversified (and which has separate and distinct divisions) if Executive
      first certifies to the Company in writing that such prospective employer
      is a separate and distinct division of the Conflicting Organization and
      that Executive will not render services directly or indirectly in
      respect of any Conflicting Product.  Such twelve (12) month time period
      shall be tolled during any period that Executive is engaged in activity
      in violation of this covenant.
    

    
      (b)                Judicial
      Construction.  Executive and the Company agree that, if the period
      of time or the scope of this Covenant Not to Compete shall be adjudged
      unreasonably overbroad in any court proceeding, then the period of time
      and/or scope shall be modified accordingly, so that this covenant may be
      enforced with respect to such services or geographic areas and during
      such period of time as is judged by the court to be reasonable.
    

    
      (c)                Definitions.  For
      purposes of this Agreement, the following terms shall have the following
      meanings:  
    

    
      "Conflicting Product" means any product, method or process,
      system or service of any person or organization other than the Company
      that is the same as, similar to or interchangeable with any product,
      method or process, system or service that was provided or under
      development by the Company or any of its Affiliates at the time
      Executive's employment with the Company terminates, or about which
      Executive acquired any Confidential Information or developed any
      Executive Work Product.
    

    
      
        

        

      

      
        
          19
        

        
          

        

      

      
        

        

      

    

    
      "Conflicting Organization" means any person or organization
      which is engaged in research on or development, production, marketing,
      licensing, selling or servicing of any Conflicting Product.
    

    
      5.12               Non-Solicitation
    

    
      For a period of twelve (12) months after termination of employment with
      the Company for any reason, Executive shall not directly or indirectly
      solicit or hire, or assist any other person in soliciting or hiring, any
      person employed by the Company (as of the date of Executive's
      termination) or any person who, as of the date of Executive's
      termination, was in the process of being recruited by the Company, or
      induce any such employee to terminate his or her employment with the
      Company.
    

    
      5.13          Judicial
      Enforcement
    

    
      In the event of a breach or violation of any provision of this Article 5
      by Executive, the parties agree that, in addition to any other remedies
      it may have, the Company shall be entitled to equitable relief for
      specific performance, and Executive hereby agrees and acknowledges that
      the Company has no adequate remedy at law for the breach of the
      employment covenants contained herein.
    

    
      
        

        

      

      
        
          20
        

        
          

        

      

      
        

        

      

    

    
      Article 6.   Miscellaneous
    

    
      6.1                Notices
    

    
      All notices or other communications which are required or permitted
      hereunder shall be deemed to be sufficient if contained in a written
      instrument given by personal delivery, air courier or registered or
      certified mail, postage prepaid, return receipt requested, addressed to
      such party at the address set forth below or such other address as may
      thereafter be designated in a written notice from such party to the
      other party:
    

    
    	
          To Company:
        	
          Sucampo Pharmaceuticals, Inc.
        
	

        	
          4520 East West Highway, Third Floor
        
	

        	
          Bethesda, Maryland 20814
        
	

        	
          Attention: Chief Executive Officer
        
	

        	
           
        
	
          To Executive:
        	
          Mr. James Egan
        
	

        	
          6408 Garnett Drive
        
	

        	
          Chevy Chase, MD 20815
        

    

    

    

    
      All such notices, advances and communications shall be deemed to have
      been delivered and received (i) in the case of personal delivery, on the
      date of such delivery, (ii) in the case of air courier, on the business
      day after the date when sent and (iii) in the case of mailing, on the
      third business day following such mailing.
    

    
      6.2                Headings
    

    
      The headings of the articles and sections of this Agreement are inserted
      for convenience only and shall not be deemed a part of or affect the
      construction or interpretation of any provision hereof.
    

    
      
        

        

      

      
        
          21
        

        
          

        

      

      
        

        

      

    

    
      6.3                Modifications;
      Waiver
    

    
      No modification of any provision of this Agreement or waiver of any
      right or remedy herein provided shall be effective for any purpose
      unless specifically set forth in a writing signed by the party to be
      bound thereby.  No waiver of any right or remedy in respect of any
      occurrence or event on one occasion shall be deemed a waiver of such
      right or remedy in respect of such occurrence or event on any other
      occasion.
    

    
      6.4                Entire
      Agreement
    

    
      This Agreement contains the entire agreement of the parties with respect
      to the subject matter hereof and supersedes all other agreements, oral
      or written, heretofore made with respect thereto including, without
      limitation, the offer letter between Executive and the Company dated
      September 14, 2009.
    

    
      6.5                Severability
    

    
      Any provision of this Agreement that may be prohibited by, or unlawful
      or unenforceable under, any applicable law of any jurisdiction shall, as
      to such jurisdiction, be ineffective without affecting any other
      provision hereof.  To the full extent, however, that the provisions of
      such applicable law may be waived, they are hereby waived, to the end
      that this Agreement be deemed to be a valid and binding agreement
      enforceable in accordance with its terms.
    

    
      6.6                Controlling
      Law
    

    
      This Agreement has been entered into by the parties in the State of
      Maryland and shall be continued and enforced in accordance with the laws
      of Maryland.  
    

    
      
        

        

      

      
        
          22
        

        
          

        

      

      
        

        

      

    

    
      6.7                Arbitration
    

    
      Any controversy, claim, or breach arising out of or relating to this
      Agreement or the breach thereof shall be settled by arbitration in the
      State of Maryland in accordance with the rules of the American
      Arbitration Association for commercial disputes and the judgment upon
      the award rendered shall be entered by consent in any court having
      jurisdiction thereof; provided, however, that this
      provision shall not preclude the Company from seeking injunctive or
      similar relief from the courts to enforce its rights under the
      Employment Covenants set forth in Article 5 of this Agreement.  It is
      understood and agreed that, in the event the Company gives notice to
      Executive of termination for Cause and it should be finally determined
      in a subsequent arbitration that Executive's termination was not for
      Cause as defined in this Agreement, then the remedy awarded to Executive
      shall be limited to such compensation and benefits as Executive would
      have received in the event of Executive's termination other than for
      Cause at the same time as the original termination.
    

    
      6.8                Assignments
    

    
      Subject to obtaining Executive's prior approval, which shall not be
      unreasonably withheld or delayed, the Company shall have the right to
      assign this Agreement and to delegate all rights, duties and obligations
      hereunder to any entity that controls the Company, that the Company
      controls or that may be the result of the merger, consolidation,
      acquisition or reorganization of the Company and another
      entity.  Executive agrees that this Agreement is personal to Executive
      and Executive's rights and interest hereunder may not be assigned, nor
      may Executive's obligations and duties hereunder be delegated (except as
      to delegation in the normal course of operation of the Company), and any
      attempted assignment or delegation in violation of this provision shall
      be void.
    

    
      
        

        

      

      
        
          23
        

        
          

        

      

      
        

        

      

    

    
      6.9                Read
      and Understood
    

    
      Executive has read this Agreement carefully and understands each of its
      terms and conditions.  Executive has sought independent legal counsel of
      Executive's choice to the extent Executive deemed such advice necessary
      in connection with the review and execution of this Agreement.
    

    
      IN WITNESS WHEREOF, the parties have executed this Agreement as
      of the date first indicated above.
    

    
    	
           
        	
          SUCAMPO PHARMACEUTICALS, INC.
        
	

        	
           
        
	

        	
          By: /s/ RYUJI UENO
        
	

        	
          Ryuji Ueno, M.D., Ph.D., Ph.D.
        
	

        	
          Chief Executive Officer
        
	

        	
           
        
	

        	
          /s/ JAMES J. EGAN
        
	

        	
          James J. Egan
        

    

    

    

    

    

    
      24

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