Document:

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                                                                 EXHIBIT 10.1(b)

                               SECOND AMENDMENT TO
                   SALES, MARKETING AND DISTRIBUTION AGREEMENT

         THIS SECOND AMENDMENT TO SALES, MARKETING AND DISTRIBUTION AGREEMENT
(the "Second Amendment") is made and entered into as of January 1, 2002 (the
"Effective Date"), by and between GENOMIC SOLUTIONS INC., a Delaware corporation
("GSI") and PERKINELMER LIFE SCIENCES, INC., a Delaware corporation and its
Affiliates ("PKI"). "Affiliates" of PKI shall mean any person, corporation or
other business entity controlled, controlled by or under common control with
PKI, with "control" meaning a fifty percent (50%) or greater ownership interest.

The following facts underlie this Agreement:

         Pursuant to a certain Sales, Marketing and Distribution Agreement dated
         December 14, 1999 (the "Original Agreement"), as amended by a First
         Amendment to Sales, Marketing and Distribution Agreement dated April
         18, 2001 (the "First Amendment"), Genomic Solutions Inc. appointed
         PerkinElmer, Inc. as its representative to promote, market and
         distribute its products. The parties desire to further amend the
         Original Agreement and the First Amendment, pursuant to the terms and
         conditions of this Second Amendment.

         NOW THEREFORE, for and in consideration of the mutual covenants and
undertakings set forth herein, the parties hereby further amend the Original
Agreement and the First Amendment as follows:

1.       DEFINITIONS. All capitalized terms defined in the Original Agreement,
         as amended by the First Amendment, shall have the meanings set forth in
         such agreements. In addition, the Original Agreement and First
         Amendment are further amended to add the following new defined term:

                  "INVESTIGATOR PRODUCTS" means GSI's Investigator(TM) 2D gel
                  hardware (consisting of gel rigs, casting rigs, power supplies
                  and chillers) and related consumables, including Duracryl(R).

2.       GSI DISTRIBUTOR APPOINTMENTS. Exhibit A of the First Amendment is
         superceded and replaced in its entirety by Exhibit A, attached hereto.
         Exhibit B-1 of the First Amendment is deleted in its entirety. In
         addition, Section 3(a) -- 3(d) of the Original Agreement and Sections
         3(b) and 3(c) of the First Amendment are superceded and replaced in
         their entirety as follows:

         (a)      Non-Exclusive Rights and Responsibilities of PKI. Effective as
                  of the date of this Agreement, PKI shall have the
                  non-exclusive right and responsibility to engage in sales,
                  marketing, distribution and field service activities:

                  (i)      with respect to GSI Products (other than those
                           covered by (ii) and (iii) below), in any market or
                           geographical area other than Core Markets, provided,
                           that PKI shall have the right to distribute products
                           of GSI's Cartesian Technologies subsidiary outside of
                           Core Markets as provided in Exhibit B attached;

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                  (ii)     with respect to GeneMAP DNA Microarrays, Investigator
                           Products, and the HybStation currently marketed by
                           GSI in any market or geographical area of the world;
                           and

                  (iii)    with respect to the G3Library Management System
                           currently marketed by GSI, in any market or
                           geographical area of the world other than Japan.

3.       ADDITIONAL AMENDMENTS

         (a)      The first sentence of Section 5(e) of the First Amendment is
                  amended to delete the words "and Proteomic Services".

         (b)      Section 6(a) of the First Amendment is amended and superceded
                  in its entirety to read as follows:

                           PKI shall have the non-exclusive right and
                           responsibility to engage in sales, marketing,
                           distribution and field service activities with
                           respect to GeneMAP DNA Microarrays throughout the
                           world. PKI shall be permitted to purchase GeneMAP DNA
                           Microarrays in bulk, with minimum purchases of ten
                           arrays for each array type, and to repackage or sell
                           such bulk purchased arrays on a private label basis
                           under such name as PKI shall elect, provided, that
                           PKI shall be responsible for providing all support
                           for such repackaged or private labeled arrays.

         (c)      Section 6(b) of the Original Agreement and Section 7 of the
                  First Amendment are deleted in their entirety.

         (d)      Section 8(b) of the First Amendment is amended to delete the
                  fourth and fifth sentences and to add the following:

                           All orders shall be bona fide, non-cancelable and
                           properly addressed, except that PKI reserves the
                           right to cancel in writing any purchase order not
                           shipped by GSI within 60 days of order receipt. GSI
                           may ship product upon receipt of any order to the
                           designated address, provided, that up to 10% of PKI's
                           purchase orders may specify a ship date within the
                           same fiscal quarter as the purchase order date and
                           GSI shall ship the product on such designated ship
                           date.

4.       EFFECT OF AMENDMENT. Except as provided in this Second Amendment, all
         other terms of the Original Agreement and First Amendment shall remain
         in full force and effect without modification.

                         [signatures on following page]

                                       2

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         IN WITNESS WHEREOF, the undersigned have executed and delivered this
Second Amendment to Sales, Marketing and Distribution Agreement as of the date
and year first above written.

                               GENOMIC SOLUTIONS INC.

                               By:      /s/ Jeffrey S. Williams
                                        --------------------------------------

                               Its:     President and Chief Executive Officer

                               PERKINELMER LIFE SCIENCES, INC.

                               By:      Petri Myllyneva
                                        --------------------------------------

                               Its:     Senior Vice President
                                        --------------------------------------

                                       3

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                                    EXHIBIT A

<TABLE>
<CAPTION>
-----------------------------------------------------------------
                                                     2002 PRICES
GSNL PRODUCT                                         PKI TRANSFER
-----------------------------------------------------------------
<S>                                                  <C>
 G3 Picking                                           $      ***
 G3 32 pin                                            $      ***
 G3 48 Pin                                            $      ***
 G3 Librarian                                         $      ***
 Hybridization Station                                $      ***
 UC-4                                                 $      ***
 GeneTAC LS-IV  2c                                    $      ***
 GeneTAC LS-IV 4c                                     $      ***
 Integtrator s/w                                      $      ***
 4-day Biochip Training Course                        $      ***
 2-day Biochip Training Course

   Investigator 2-D                                   $      ***
   ProPic*                                            $      ***
   ProGest                                            $      ***
   ProMS                                              $      ***
   ProPrep - four plate                               $      ***
   Protein Warehouse                                  $      ***
 3-day Proteomics Training Course                     $      ***
 1-day Proteomics Training Course                     $      ***
</TABLE>

Genemap Microarrays: ***% discount off U.S. list price

All other reagents and consumables: ***% discount off list price

All other GSI products not detailed above (e.g., upgrade kits, etc.) shall
remain at the current 2001 prices.

***Certain information on this page has been omitted and filed separately with
the Commission. Confidential treatment has been requested for the omitted
portion.

                                       4

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                                    EXHIBIT B

The following is a list of countries where Genomic Solutions subsidiary,
Cartesian Technologies, Inc., has current exclusive distribution relationships.
Any extension or renewal of such relationships will be subject to PerkinElmer's
right to engage in distribution of Cartesian products in such countries on a
non-exclusive basis. In addition, in the event that Genomic Solutions terminates
any distributors in such countries prior to expiration of existing agreements
for non-performance, PerkinElmer shall be permitted to distribute Cartesian
products in such countries on a non-exclusive basis.

DISTRIBUTOR COUNTRY                                  TERMINATION DATE
-------------------                                  ----------------

Singapore                                            9/29/02

Malaysia                                             9/29/02

Thailand                                             10/10/02

China                                                12/31/03*

Taiwan                                               12/31/03*

Korea                                                12/31/03*

Denmark                                              12/31/02

Sweden                                               12/31/02

Finland                                              12/31/02

Norway                                               12/31/02

Netherlands                                          12/31/02

Belgium                                              12/31/02

Germany                                              12/31/02

*Termination dates agreed to based on recent negotiations with documentation in
process

                                       5<PAGE>
                                                                        10.16(b)

FIFTH AMENDMENT TO LEASE AGREEMENT

         This Fifth Amendment to Lease Agreement ("Fifth Amendment") is entered
into between Highland Industrial Properties, L.L.C., a Michigan limited
liability company, as Lessor, and Genomic Solutions Inc., as Lessee.

                                    RECITALS:

         A. Pursuant to a certain Lease Agreement dated August 7, 1997, between
Lessor and Lessee (f/k/a B. I. Systems Corporation), Lessee leased certain
premises located at 4355 Varsity Drive, Suite E, located in the Ann Arbor
Commerce Park. Pursuant to four amendments to the Lease, Lessee has leased
additional premises from Lessor. The Lease and the first through fourth
amendments, of such Lease are collectively referred to as the "Lease."

         B. Lessee desires to lease additional space from Lessor.

         C. Based on the foregoing, Lessor and Lessee desire to further amend
the Lease in the manner described below.

         THEREFORE, for good and valuable consideration, the receipt and
sufficiency of which is acknowledged, the parties agree that the Lease shall be
further amended as follows:

         1. ADDITIONAL PREMISES. Lessor agrees to lease to Lessee and Lessee
agrees to lease from Lessor certain additional leased premises consisting of
approximately six thousand five hundred (6,500) square feet of office and
production space, commonly known as 4395 Varsity Drive, Suite C (the "Additional
Premises"). Lessee acknowledges that the Additional Premises are currently
occupied by another tenant. If such tenant fails to vacate the Additional
Premises on a timely basis, Lessor will use its good faith efforts to cause such
tenant to vacate, including without limitation, the commencement of legal
proceedings for possession of the Additional Premises. Lessor shall not be
liable to Lessee for any damages as a result of any delay in delivering the
Additional Premises, and Lessee shall have no right to terminate the Lease or
abate its current rental obligations due to such delay. Notwithstanding the
foregoing, if the Additional Premises are not ready for Lessee's occupancy on or
before October 31, 2001, Lessee will have the right, as its sole and exclusive
remedy, to terminate this Fifth Amendment. In the event that Lessee elects to so
terminate this Fifth Amendment, the Lease, including the first four amendments
thereto, will remain in full force and effect.

         The Additional Premises shall be deemed ready for Lessee's occupancy,
when Lessor provides Lessee with written notice that the Additional Premises
have been vacated, regardless of when Lessee thereafter elects to occupy the
Additional Premises. Lessee acknowledges and agrees that the Additional Premises
are being leased to Lessee in "as-is, where-is" condition.

         2. LEASED PREMISES. Commencing on the date that the Additional Premises
are ready for Lessee's occupancy, the Leased Premises under the Lease shall be
deemed to consist of twenty seven thousand six hundred sixty-five (27,665)
square feet, consisting of approximately

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twenty thousand nine hundred seventy six (20,976) square feet of premises
located at 4355 Varsity Drive, Suite C, D, E and F and approximately six
thousand six hundred eighty nine (6,689) square feet located at 4401 Varsity
Drive, Suite F. All references to the Leased Premises under the Lease shall be
deemed to refer to the foregoing premises. Commencing on the date the Additional
Premises are ready for Lessee's occupancy, Lessee's proportionate share of real
estate taxes and assessments under Section 4 of the Lease shall be as follows:
(i) with respect to the portion of the Leased Premises which are located at 4355
Varsity Drive (Suite C, D, E and F), Lessee's proportionate share shall be
72.89%; (ii) with respect to the portion of the Leased Premises located at 4401
Varsity Drive (Suite F), Lessee's proportionate share shall be 23.25%.
Commencing on the date the Additional Premises are ready for Lessee's occupancy,
Lessee's proportionate share of common area maintenance and operating expenses
under Section 6 of the Lease shall be based upon the proportion of the square
footage comprising the Leased Premises to the total number of square feet within
all of the Buildings in the Ann Arbor Commerce Park.

         3. BASIC RENTAL. From the date the Additional Premises are ready for
Lessee's occupancy until December 31, 2001, the minimum monthly rate for the
Leased Premises shall be Twenty Two Thousand Nine Hundred Eighty Five and 00/100
($22,985.00) Dollars per month, which amount shall be prorated in the event the
Additional Premises are ready for occupancy on a date other than the first day
of a calendar month. For calendar months January, 2002 through June 30, 2004,
the minimum monthly rent for the Leased Premises shall be Twenty Three Thousand
Five Hundred Sixty One and 36/100 ($23,561.36) Dollars per month.

         Notwithstanding, the foregoing, Lessee shall not be obligated to pay
minimum monthly rent for the first month following the date the Additional
Premises are ready for Lessee's occupancy. If the Additional Premises are ready
for occupancy on a date other than the first day of a calendar month, the
foregoing rent credit shall be applied toward the thirty (30) day period
immediately following the date the Additional Premises are ready for occupancy
and Lessee shall be obligated to pay a prorated portion of the minimum monthly
rent for the remainder of the second calendar month following the date the
Additional Premises are ready for occupancy. Lessee will be obligated to pay its
proportionate share of common area maintenance, real estate taxes, and insurance
during the period that Lessee is entitled to free rent.

         4. LEASE TERM. The term of the Lease shall be extended to June 30,
2004.

         5. RIGHT OF FIRST OFFER. Provided that Lessee is not in default under
the Lease, if the premises located at 4355 Varsity Drive, Suites A and B become
available for leas during the term of Lessee's Lease, Lessor agrees to offer to
lease such premises to Lessee prior to marketing such premises to third parties.
If Lessee offers to lease such premises to Lessee, and, if, for any reason, the
parties have not entered into an amendment to the Lease, or a new lease for such
premises within fifteen (15) days from the date Lessor notifies Lessee in
writing that such premises are available for lease, Lessor shall have the right
to offer such space to third parties.

         6. RATIFICATION. To the extent not modified by this Fifth Amendment,
the terms and provisions of the Lease, including the First through Fourth
Amendments thereto, shall continue

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in full force and effect and are hereby ratified by the parties. This Fifth
Amendment to Lease has been executed by Lessor and Lessee as of the dates
written below their signatures.

                                   HIGHLAND INDUSTRIAL PROPERTIES,
                                   L.L.C., a Michigan limited liability company,

                                   By:      /s/ Mark D. Lewis
                                      ------------------------------------------

                                   Its:  Member

Dated: September 10, 2001

                                   GENOMIC SOLUTIONS INC.

                                   By:      /s/ Gary A. Kendra
                                      ------------------------------------------

                                   Its:  Executive Vice President

Dated: September 7, 2001

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