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                                                                    EXHIBIT 10.5

                              EMPLOYMENT AGREEMENT

     EMPLOYMENT AGREEMENT, dated October 28,1999 and effective as of November 1,
(the "Effective Date"), by and between AVAX Technologies, Inc., a Delaware
corporation (the "Corporation"), and Mr. Warren B. Dudley, an individual (the
"Executive").

     WHEREAS, the Corporation desires to employ the Executive and the Executive
desires to accept such employment, on the terms and conditions set forth herein;
and

     WHEREAS, the Corporation and the Executive wish to replace the Employment
Letter Agreement dated October 8, 1999 hereby in its entirety;

     NOW, THEREFORE, in consideration of the foregoing and the mutual promises
and covenants herein contained, it is agreed as follows:

1.   EMPLOYMENT; DUTIES, POWERS AND AUTHORITY

     (a)    The Corporation engages and employs the Executive, and the Executive
hereby accepts engagement and employment as a corporate officer in the position
of Senior Vice President for Marketing, Sales, and Business Development of the
Corporation.

     (b)    The Executive shall perform his duties with all such powers and
authority as appertain to such office in accordance with and subject to overall
direction of the President and Chief Executive Officer (the "CEO") of the
Corporation. The Executive shall perform his duties hereunder from the
Corporation's offices and at such other places as shall be necessary according
to the needs, business or opportunities of the Corporation; provided, that the
Executive acknowledges and agrees that the performance by the Executive of his
duties hereunder may require significant domestic and international travel by
the Executive.

     (c)    As Senior Vice President for Marketing, Sales, and Business
Development, the Executive shall supervise, control, and be responsible for
marketing and sales of all products developed and sold by the Corporation and
for the development of new business opportunities within the Corporation's field
of business and shall have such other executive powers and duties as may from
time to time be prescribed by the CEO. The Executive shall report solely to the
CEO. The Executive shall also work closely with other executive officers of the
Corporation in pursuit of business development and marketing opportunities for
the Corporation.

     (d)    The Executive shall devote such of his time and efforts as shall be
necessary to the proper discharge of his duties and responsibilities under this
Agreement.

2.   TERM

     The Executive's employment hereunder shall, unless earlier terminated, be
for an initial term of three (3) years (the "Initial Period") commencing on the
Effective Date of this Employment Agreement. This Employment Agreement with the
Corporation shall be automatically renewed for successive one (1) year periods
(the "Renewal Period(s)"), which are subject to earlier termination as
hereinafter provided, unless either the Corporation or the Executive gives
written notice to the other that the Employment Agreement shall terminate at the
end of the Initial Period or the then-current Renewal Period at least three (3)
months prior to the end of such period. The Initial Period and any Renewal
Periods are collectively referred to herein as the "Employment Period."

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3.   COMPENSATION

     (a)    As compensation for the performance of his duties on behalf of the
Corporation, the Executive shall be compensated during the Employment Period as
follows:

            (i)   A base salary of not less than $190,000 per annum (the "Base
                  Salary"), subject to annual review commencing 12 months from
                  the Effective Date;

            (ii)  The Executive shall be eligible to receive an annual incentive
                  bonus of up to 100% of his base salary beginning with the
                  first year of Employment. The CEO shall annually meet with the
                  Executive to establish such goals and performance standards as
                  the Board and CEO determine are to be taken into account in
                  determining the Executive's discretionary bonus awards. For
                  the first two years' bonus, it is the intent of the parties to
                  create realistic goals that would permit Executive's annual
                  bonus to be between 30%-45% of his base salary.

            (iii) The Corporation shall withhold and appropriately pay all
                  applicable federal, state and local taxes, social security and
                  workers' compensation contributions and such other amounts as
                  may be required by law or agreed upon by the parties with
                  respect to the compensation payable to the Executive pursuant
                  to this Section 3(a) or otherwise in connection with his
                  employment by the Corporation.

     (b)    The Executive shall receive on the Effective Date options to
purchase 150,000 shares of Common Stock, par value $.004. These options shall
vest and be exercisable (subject to any resale restrictions of an underwriter of
the Corporation's securities), in accordance with the provisions and terms of
the Schedule attached as Exhibit II, and in accordance with the terms and
conditions contained in the Corporation's Stock Option Plan. In addition, from
time to time, at the discretion of the Board of Directors, the Executive may be
entitled to additional stock options pursuant to the Corporation's Stock Option
Plan at the sole discretion of the Board of Directors of the Corporation.
Anything herein to the contrary, all stock options shall vest upon any Change in
Control, as such term is defined in Section 9.

     (c)    The Corporation shall reimburse the Executive for all normal, usual
and necessary expenses incurred by the Executive in furtherance of the business
and affairs of the Corporation, including reasonable travel and entertainment,
against receipt by the Corporation of appropriate vouchers or other proof of the
Executive's expenditures and otherwise in accordance with such Expense
Reimbursement Policy as may from time to time be adopted by the Board of
Directors of the Corporation.

     (d)    The Executive shall be entitled, during the Employment Period, to
four (4) weeks vacation each year and to such other sick leave as is provided
under the normal policies in place from time to time for employees of the
Corporation.

     (e)    During the Employment Period, the Executive shall be entitled to
participate in any group insurance, life insurance, hospitalization, medical,
dental, health and accident, disability or similar plan or program of
Corporation now existing or established hereafter to the extent that he is
eligible under the general provisions thereof.

     (f)    Subject to paragraphs (c) through (e) of Section 9 below, the
Executive must be an employee of the Corporation at the time that any
compensation is due in order to receive such compensation.

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4.   REPRESENTATIONS AND WARRANTIES BY  EXECUTIVE AND CORPORATION

     The Executive hereby represents and warrants to the Corporation as follows:

     (a)    Neither the execution and delivery of this Agreement nor the
performance by the Executive of his duties and other obligations hereunder
violate or will violate any statute, law, determination or award, or conflict
with or constitute a default under (whether immediately, upon the giving of
notice or lapse of time or both) any prior employment agreement, contract, or
other instrument to which the Executive is a party or by which he is bound.

     (b)    The Executive has the full right, power and legal capacity to
execute and deliver this Agreement and to perform his duties and other
obligations hereunder. This Agreement constitutes the legal, valid and binding
obligation of the Executive enforceable against him in accordance with its
terms. No approvals or consents of any persons or entities are required for the
Executive to execute and deliver this Agreement or perform his duties and other
obligations hereunder.

     The Corporation hereby represents and warrants to the Executive as follows:

     (a)    The Corporation is a corporation duly organized, validly existing
and in good standing under the laws of the State of Delaware, which has all
requisite corporate power and authority to own its properties and conduct its
business in the manner presently contemplated.

     (b)    The Corporation has full power and authority to enter into this
Agreement and to incur and perform its obligations hereunder. This Agreement
constitutes the legal, valid and binding obligation of the Corporation
enforceable against the Corporation in accordance with its terms.

     (c)    The execution, delivery and performance by the Corporation of this
Agreement does not conflict with or result in a breach or violation of or
constitute a default under (whether immediately, upon the giving of notice or
lapse of time or both) the certificate of incorporation or by-laws of the
Corporation, or any agreement or instrument to which the Corporation is a party
or by which the Corporation or any of its properties may be found or affected.

5.   NON-COMPETITION

     (a)    The Executive understands and recognizes that his services to the
Corporation are special and unique and agrees that, during the Employment Period
and for a period of two years from the date of termination of his employment
hereunder, he shall not in any manner, directly or indirectly, on behalf of
himself or any person, firm, partnership, joint venture, corporation or other
business entity ("Person"), enter into or engage in any business activity that
is directly or indirectly competitive with the Corporation's business relating
to chemotherapies or immunotherapies for the treatment of cancer, either as an
individual for his own account, or as a partner, joint venturer, executive,
agent, consultant, salesperson, officer, director or shareholder of a Person
operating or intending to operate within the area that the Corporation is, at
the date of termination, conducting its business (collectively, "Restricted
Business"); provided, however, that nothing herein will preclude the Executive
from holding one percent (1%) or less of the stock of any publicly traded
company. This paragraph 5(a) shall be null and void if the Executive terminated
his employment for just cause pursuant to Section 10(a)(iv) below or if this
Agreement is terminated prior to the end of the Initial Term or any Additional
Term then in effect by the Corporation other than pursuant to Section 10(a)(ii)
or (iii) below.

     (b)    In the event that the Executive breaches any provisions of this
Section 5 or there is a threatened breach, then, in addition to any other rights
which the Corporation may have, the Corporation

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shall be entitled, without the posting of a bond or other security, to
injunctive relief to enforce the restrictions contained herein. In the event
that an actual proceeding is brought in equity to enforce the provisions of this
Section 5, the Executive shall not urge as a defense that there is an adequate
remedy at law nor shall the Corporation be prevented from seeking any other
remedies which may be available.

6.   CONFIDENTIAL INFORMATION

     (a)    The Executive agrees that during the course of his employment and
for a period of five years after termination, he will not disclose or make
accessible to any other person, the Corporation's secret and confidential
products, services and technology, both current and under development, promotion
and marketing programs, lists, trade secrets and other confidential and
proprietary business information of the Corporation or any of its clients except
to the extent the same have become generally known to the public other than
through a breach of this Section 6. The Executive agrees: (i) not to use any
such information for himself or others during such five-year period; and (ii)
not to take any such material or reproductions thereof from the Corporation's
facilities at any time during his employment by the Corporation, except as
required in the Executive's duties to the Corporation. The Executive agrees
immediately to return all such material and reproductions thereof in his
possession to the Corporation upon request and in any event upon termination of
employment.

     (b)    Except with prior written authorization by the Corporation, the
Executive agrees not to disclose or publish any of the confidential, technical
or business information or material of the Corporation, its clients or any other
party to whom the Corporation owes an obligation of confidence, at any time
during or for a period of three (3) years after his employment with the
Corporation.

7.   OWNERSHIP OF PROPRIETARY INFORMATION

     (a)    The Executive agrees that all secret and confidential information
that has been created, discovered or developed by the Corporation, its
subsidiaries, affiliates, successors or assigns (collectively, the "Affiliates")
(including, without limitation, information relating to the development of the
Corporation's business created by, discovered by, developed by or made known to
the Corporation or the Affiliates by Executive during the Term and information
relating to Corporation's customers, suppliers, consultants, and
licensees) and/or in which property rights have been assigned or otherwise
conveyed to the Corporation or the Affiliates, shall be the sole property of the
Corporation or the Affiliates, as applicable, and the Corporation or the
Affiliates, as the case may be, shall be the sole owner of all patents,
copyrights and other rights in connection therewith, including but not limited
to the right to make application for statutory protection. All of the
aforementioned information is hereinafter called "Proprietary Information." By
way of illustration but without limitation, Proprietary Informations shall
include all discoveries, structures, inventions, designs, ideas, works of
authorship, copyrightable works, trademarks, copyrights, formulas, data,
know-how, show-how, improvements, inventions, product concepts, techniques,
information or statistics contained in, or relating to, marketing plans,
strategies, forecasts, blueprints, sketches, records, notes, devices, drawings,
customer lists, patent applications, continuation applications,
continuation-in-part applications, file wrapper continuation applications and
divisional applications and information about the Corporation's or the
Affiliates' employees and/or consultants (including, without limitation, the
compensation, job responsibility and job performance of such employees and/or
consultants).

     (b)    The Executive further agrees that at all times, both during the
Employment Period and after the termination of this Agreement, he will keep in
confidence and trust all Proprietary Information, and he will not use or
disclose any Proprietary Information or anything directly relating to it without
the written consent of the Corporation or the Affiliates, as appropriate, except
as may be necessary in the ordinary course of performing his duties hereunder
and except for academic, non-commercial research purposes with the prior written
approval of the Board of Directors. The Executive acknowledges that the

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Proprietary Information constitutes a unique and valuable asset of the
Corporation and each Affiliate acquired at great time and expense, which is
secret and confidential and which will be communicated to the Executive, if at
all, in confidence in the course of performance of his duties hereunder, and
that any disclosure or other use of the Proprietary Information other than for
the sole benefit of the Corporation or the Affiliates would be wrongful and
could cause irreparable harm to the Corporation or the Affiliates, as the case
may be.

     Notwithstanding the foregoing, the parties agree that, at all such times,
the Executive is free to use (i) information in the public domain not as a
result of a breach of this Agreement, (ii) information lawfully received from a
third party and (iii) the Executive's own skill, knowledge, know-how and
experience to whatever extent and in whatever way he wishes, in each case
consistent with his obligations as an officer of the Corporation and that, at
all times, the Executive is free to conduct any non-commercial research not
relating to the Corporation's business.

8.   DISCLOSURE AND OWNERSHIP OF INVENTIONS

     (a)    During the Employment Period, the Executive agrees that he will
promptly disclose to the Corporation, or any persons designated by the
Corporation, all improvements, inventions, designs, ideas, works of authorship,
copyrightable works, discoveries, trademarks, copyrights, trade secrets,
formulas, processes, structures, product concepts, marketing plans, strategies,
customer lists, information about the Corporation's or the Affiliates' employees
and/or consultants (including, without limitation, job performance of such
employees and/or consultants), techniques, blueprints, sketches, records, notes,
devices, drawings, know-how, data, whether or not patentable, patent
applications, continuation applications, continuation-in-part applications, file
wrapper continuation applications and divisional applications having to do with
the products and services of the Corporation, made or conceived or reduced to
practice or learned by him, either alone or jointly with others, during the
Employment Period (all said improvements, inventions, designs, ideas, works of
authorship, copyrightable works, discoveries, trademarks, copyrights, trade
secrets, formulas, processes, structures, product concepts, marketing plans,
manufacturing or other strategies, customer lists, information about the
Corporation's or the Affiliates' employees and/or consultants, techniques,
blueprints, sketches, records, notes, devices, drawings, know-how, data, patent
applications, continuation applications, continuation-in-part applications, file
wrapper continuation applications and divisional applications shall be
collectively hereinafter called "Inventions").

     (b)    The Executive agrees that all Inventions shall be the sole property
of the Corporation to the maximum extent permitted by applicable law and to the
extent permitted by law shall be "works made for hire" as that term is defined
in the United States Copyright act (17 USCA, Section 101). The Corporation shall
be the sole owner of all patens, copyrights, trade secret rights, and other
intellectual property or other rights in connection therewith. The Executive
hereby assigns to the Corporation all right, title and interest he may have or
acquire in all Inventions. The Executive further agrees to assist the
Corporation in every possible way (but at the Corporation's expense) to obtain
and from time to time, enforce patents, copyrights or other rights in said
Inventions in any and all countries, and to that end the Executive will execute
all documents necessary:

            (i)   to apply for, obtain and vest in the name of the Corporation
                  alone (unless the Corporation otherwise directs) letters,
                  patents, copyrights or other analogous protection in any
                  country throughout the world and when so obtained or vested to
                  renew and restore the same; and

            (ii)  to defend any opposition proceedings in respect of such
                  applications and any opposition proceedings or petitions or
                  applications for revocation of such letters, patents,
                  copyrights or other analogous protection.

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     (c)    The Executive's obligation to assist the Corporation in obtaining
and enforcing patents and copyrights for the Inventions in any and all countries
shall continue beyond the Employment Period, but the Corporation agrees to
compensate the Executive a reasonable rate after the expiration of the
Employment Period for time actually spent by the Executive at the Corporation's
request on such assistance.

9.   TERMINATION

     (a)    The Executive's Employment Period hereunder shall begin on the
Effective Date and shall continue for the period set forth in Section 2 hereof
unless sooner terminated upon the first to occur of the following events:

            (i)   The death of the Executive;

            (ii)  The Disability (as defined below in Section 10(b)) of the
                  Executive;

            (iii) Termination by the CEO or the Board for "Just Cause", provided
                  that the Corporation shall have given proper notice thereof,
                  and the Executive shall have had at least a thirty (30) day
                  period to cure such "Just Cause." For the Purposes of this
                  Agreement, any of the following actions by the Executive shall
                  constitute "Just Cause":

                  (A)  Material breach by the Executive of Sections 5, 6, 7, or
                       8 of this Agreement;

                  (B)  Material breach by the Executive of any provision of this
                       Agreement other than Sections 5, 6, 7, or 8 which is not
                       cured by the Executive within 30 days of written notice
                       thereof from the Corporation;

                  (C)  Continued negligent performance by the Executive of his
                       specified duties as Senior Vice President for Marketing,
                       Sales and Business Development, as determined by the
                       Board after prior written notice to the Executive and an
                       opportunity for the Executive to be heard by the Board;

                  (D)  Any willful or deliberate misconduct or omission on the
                       part of the Executive intended to cause harm to the
                       Corporation; or

                  (E)  The conviction of the Executive of (i) any felony or (ii)
                       any other crime involving moral turpitude;

            (iv)  Termination by the Executive for "Good Reason." Any of the
                  following actions or omissions by the Corporation shall
                  constitute "Good Reason", provided that the Executive shall
                  have given proper notice thereof, and the Corporation shall
                  have had at least a thirty (30) day period to cure such "Good
                  Reason" (the Corporation will not have the thirty day cure
                  period for a failure to timely pay Executive's base salary:

                  (A)  Material breach by the Corporation of any provision of
                       this Agreement which is not cured by the Corporation
                       within 30 days of written notice

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                       thereof from the Executive to the Corporation, specifying
                       in reasonable detail the basis for such claimed breach;

                  (B)  The failure of the Corporation to provide the Executive
                       with a position, authority or duties at least equivalent
                       to the most significant position, authority or duties
                       previously held by the Executive during the Employment
                       Period, or any reduction of the Compensation paid by the
                       Corporation to the Executive or any material reduction of
                       the benefits given by the Corporation to the Executive,
                       unless such reduction is deemed necessary by the Board or
                       CEO and is applicable to all officers of the Corporation,
                       if such circumstance is not remedied within (5) business
                       days after written notice from the Executive to the
                       Corporation; or

                  (C)  Failure to timely pay the Executive's base salary.

     (b)    For purposes hereof, a "Change of Control" shall be deemed to occur
upon either of the following:

            (i)   The sale by the Corporation of all or substantially all of its
                  assets to any person (as such term is used in Sections 13(d)
                  and 14(d) of the Securities Exchange Act of 1934), the
                  consolidation of the Corporation with any person, or the
                  merger of the Corporation with any person as a result of which
                  merger the Corporation is no longer the surviving entity, or
                  if the Survivor, the Corporation is owned by a parent company,
                  unless, following such consolidation at least a majority of
                  the members of the Board of Directors of the surviving entity
                  or transferee are members of the Board of Directors of the
                  Corporation at the time of the initial action of the Board of
                  Directors providing for such consolidation, or

            (ii)  The sale or transfer by one or more of the Corporation's
                  shareholders, in one or more transactions, related or
                  unrelated to one or more persons under circumstances whereby
                  any person and its affiliates (as hereafter defined) shall own
                  as a result of such sale or transfer and thereafter, at least
                  one-half of the outstanding shares of the Corporation.

                  An "Affiliate" shall mean any person that directly or
                  indirectly through one or more intermediaries, controls, is
                  controlled by, or is under common control with, any other
                  person.

     (c)    For purposes hereof, a "Disability" of the Executive shall be deemed
to have occurred in the event (i) the Executive is absent from work or otherwise
substantially unable to assume his normal duties for a period of 30 successive
days or an aggregate of 60 days during any 12-month period because of physical
or mental disability, accident, illness or other cause other than approved
vacation or leave of absence or (ii) the Executive is deemed by a licensed
physician designated by the Corporation and reasonably acceptable to the
Executive to have a permanent disability such that Executive will be unable to
perform his duties under this agreement. The Corporation shall have the right to
have the Executive examined by a competent physician for purposes of determining
his physical or mental incapacity.

     (d)    Upon termination by Corporation pursuant to subparagraphs (i), (ii)
or (iii) of paragraph (a) above or by Executive other than pursuant to
subparagraph (iv) of paragraph (a) above, the Executive (or his estate in the
event of termination pursuant to subparagraph (ii)), shall be entitled to
receive the Base Salary accrued but unpaid as of the date of termination.

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     (e)    Upon termination by the Corporation (other than following a Change
of Control) for any reason other than as set forth in subparagraphs (i), (ii) or
(iii) of paragraph (a) above or by the Executive for any reason set forth in
subparagraphs (iv) of paragraph (a) above, then the Corporation shall pay the
Executive, as the Executive's sole damages for such termination, a lump sum
payment equal to one hundred percent (100%) of the annual Base Salary, at the
rate in effect at the time of such termination, without set-off for any salary
earned from alternative employment. In addition, any stock options granted to
the Executive, including, but not limited to Section 3(b), shall continue to
vest according to the provisions of Section 3(b) during the twelve (12) months
following such termination. Also, the Corporation shall pay Executive's family
coverage COBRA medical coverage co-payment for the entire COBRA coverage period

     (f)    Upon termination, following a Change of Control, by the Corporation
(other than as set forth in subparagraph (i), (ii) or (iii) of paragraph (a)
above) or by the Executive for any reason set forth in subparagraphs (iv) of
paragraph (a) above, then the Corporation shall pay the Executive, as the
Executive's sole damages for such termination, a lump sum payment equal to two
(2) times the annual Base Salary at the higher of the rate in effect at the date
of termination or the rate in effect on the date of the Change of Control. Such
amount(s) shall not be set-off against amount earned from alternative
employment. In addition, any stock options granted to the Executive, including,
but not limited to Section 3 (b), shall upon such termination become immediately
vested. Also, the Corporation shall pay Executive's family coverage COBRA
medical coverage co-payment for the entire COBRA coverage period

     (g)    It shall be condition to the Executive's right to receive the
benefits provided for in paragraphs (d) and (e) of Section 3 above that the
Executive shall have delivered to the Corporation a general release dated as of
the date of termination of the Executive's employment hereunder.

10.  INDEMNIFICATION

     The Corporation shall indemnify and hold the Executive harmless to the
fullest extent permitted by the General Corporation Law of the State of
Delaware, as amended from time to time, for all amounts, (including without
limitation, judgements, fines, settlement payments, expenses and attorney's
fees) incurred or paid by the Executive in connection with any action, suit,
investigation or proceeding arising out of or relating to the performance by the
Executive of services for, or acting by the Executive as an officer or employee
of, the Corporation or any other person or enterprise at the Corporation's
request, and shall to the fullest extent permitted by the General Corporation
Law of the State of Delaware, as amended from time to time, advance all expenses
incurred or paid by the Executive in connection with, and until disposition of,
any action, suit, investigation or proceeding arising out of or relating to the
performance by the Executive of services for, or acting by the Executive as an
officer or employee of, the Corporation or any other person or enterprise at the
Corporation's request.

11.  INSURANCE

     If requested by the Corporation, the Executive agrees to cooperate with the
Corporation in obtaining for the Corporation's benefit, at the Corporation's
expense, life insurance on his life. Such cooperation shall include completing
and signing such forms or applications, undergoing physical examinations, and
such other acts as may be required in order to obtain such insurance.

12.  NOTICES

     Any notice or other communication under this Agreement shall be in writing
and shall be deemed to have been given: when delivered personally against
receipt therefor; one (1) day after being sent by Federal Express or similar
overnight delivery; or three (3) days after being mailed registered or certified

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mail, postage prepaid, return receipt requested, to either party at the address
set forth below, or to such other address as such party shall give by notice
hereunder to the other party.

     If to Corporation:

     AVAX Technologies, Inc.
     4520 Main Street, Sutie 930
     Kansas City, MO 64111

     If to Executive:

     Mr. Warren B. Dudley
     ________________________
     ________________________

13.  SEVERABILITY OF PROVISIONS

     If any provision of this Agreement shall be declared by a court of
competent jurisdiction to be invalid, illegal or incapable of being enforced in
whole or in part, the remaining conditions and provisions or portions thereof
shall nevertheless remain in full force and effect and enforceable to the extent
they are valid, legal and enforceable, and no provision shall be deemed
dependent upon any other covenant or provision unless so expressed herein.

14.  ENTIRE AGREEMENT; MODIFICATION

     (a)    This Agreement and the agreements and instruments referenced in
Section 3 (a) and (b) hereof contain the entire agreement of the parties
relating to the subject matter hereof and supersede in their entirety the
Employment Letter Agreement, and the parties hereto have made no agreements,
representations or warranties relating to the subject matter of this Agreement
which are not set forth herein or in the agreements and instruments referenced
in said Section 3(a) or (b). No modification of this Agreement shall be valid
unless made in writing and signed by the parties hereto.

     (b)    The Executive acknowledges that any cash and non-cash compensation
received by him prior to the execution of this Agreement shall be applied to the
obligations of the Corporation hereunder and that the execution of this
Agreement after the Effective Date is not intended to entitle the Executive to
any greater compensation than was originally set forth in the Employment Letter
Agreement.

15.  BINDING EFFECT

     The rights, benefits, duties and obligations under this Agreement shall
inure to, and be binding upon, the Corporation, its successors and assigns, and
upon the Executive and his legal representatives. This Agreement constitutes a
personal service agreement, and the performance of the Executive's obligations
hereunder may not be transferred or assigned by the Executive.

16.  NON-WAIVER

     The failure of either party to insist upon the strict performance of any of
the terms, conditions and provisions of this Agreement shall not be construed as
a waiver or relinquishment of future compliance therewith, and said terms,
conditions and provisions shall remain in full force and effect. No waiver of
any term or condition of this Agreement on the part of either party shall be
effective for any purpose whatsoever unless such waiver is in writing and signed
by such party.

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17.  REMEDIES FOR BREACH

     The Executive understands and agrees that any breach of Sections 5, 6, 7, 8
and 9 of this Agreement by the Executive could cause irreparable damage to the
Corporation and to the Affiliates, and that monetary damages alone would not be
adequate and, in the event of such breach, the Corporation shall have, in
addition to any and all remedies of law, the right to an injunction, specific
performance or other equitable relief to prevent or redress the violation of the
Executive's obligations under such Sections.

18.  GOVERNING LAW

     This Agreement shall be governed by, and construed and interpreted in
accordance with, the laws of the State of Missouri without regard to principles
of conflict of laws.

19.  HEADINGS

     The headings of paragraphs are inserted for convenience and shall not
affect any interpretation of this Agreement.

20.  ATTORNEY FEES

     In the event of a dispute between the parties arising out of this
Agreement, the successful party, whether or not arbitration is sought, shall be
reimbursed by the other party hereto for all costs and expenses of such dispute,
including, but not limited to, reasonable attorney fees.

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of
the day and year first above written.

                                        /s/   Warren B. Dudley
                                      --------------------------------------
                                      Warren B. Dudley

                                      AVAX TECHNOLOGIES, INC.

                                 By:    /s/   Jeffrey M. Jonas, M.D.
                                      --------------------------------------
                                      Name:  Jeffrey M. Jonas, M.D.
                                      Title: President & Chief executive officer

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                                    EXHIBIT I

                            INCENTIVE BONUS PLAN FOR
                          FIRST TWO YEARS OF EMPLOYMENT

1.   BUSINESS/STRATEGY PLANS:

     There shall be a bonus of 2% of Base Salary for the development of each
     business plan for the commmercialization and distribution of products
     developed and sold by the Corporation, such bonus to be paid for each
     country (6 total for three plans) that a business plan is developed for,
     provided such business plan is requested and reasonably approved by the
     Chief Executive Officer (an "Approved Plan"). During the first year it is
     anticipated that three such plans shall be prepared. In addition, there
     will be a 9% bonus paid on the development of an overall corporate business
     plan reasonable approved by the Chief Executive Officer.

2.   TACTICAL ROLL-OUTS (BEGINNING SALES):

     There shall be a bonus of 5% of Base Salary upon receipt of revenues from
     sales resulting from public marketing (and excluding revenues from use of
     products for clinical trials) to consumers for use of products developed by
     the Corporation, such 5% bonus to be paid for each country (15% total for
     three countries) in which such revenues are generated pursuant to an
     Approved Plan.

3.   ACTUAL SALES:

     There will be a bonus based on actual sales of products developed and sold
     by the Corporation, such bonus amount to be determined by mutual agreement
     at the outset of marketing of such products. The range of this bonus shall
     be between 0-15% of Base Salary.

     The above bonus targets may be achieved regardless of how sales are
achieved. They may be achieved regardless of whether the Corporation is
responsible for or takes part in the marketing and sales of the products itself
(i.e. bonus targets may be met even if sales targets are achieved through a
business development agreement).

     For the first two years of employment with the Corporation, the parties
contemplate a bonus of 35-40% of Base Salary based upon the above. If sales
projections are exceeded, additional bonuses for outstanding performance will be
paid up to a maximum of 100% of Base Salary (this would require hitting top
sales targets in multiple countries).

     In addition to the above, the Executive shall participate in the
Corporation's stock option plan as developed and in place from time to time by
the Board, the vesting of such options which may occur based on achievement of
performance based goals established by the CEO or the Board.

     In years following the first two years of employment, bonus targets will be
more heavily weighted towards sales figures.

                                      -11-
<Page>

                                   EXHIBIT II

                       AVAX COMMON STOCK, PAR VALUE $.004
                             OPTION VESTING SCHEDULE

     Options to purchase shares of Common Stock, par value $.004, received by
the Executive in accordance with Section 3(b) of the Employment Agreement shall
vest and be exercisable (subject to resale restrictions for a period of up to 18
months in connection with and following any public offering, which may be
imposed by the Corporation or the managing underwriter(s) of such offering),
provided you are still employed by the Corporation on such dates, at the rate of
one-sixteenth of such amount of options per quarter until the fourth anniversary
of the Effective Date at which point all remaining options shall be vested.

     Upon termination of employment, such vested options shall be exercisable
for up to 30 days thereafter; PROVIDED, HOWEVER, that if such termination is for
"Just Cause," pursant to Section 9(d) of the Employment Agreement, all options
hereunder, including vested options, shall be forfeited and of no force and
effect.

     The tax consequences to you of the grant, vesting or exercise of any such
options or the sale of any shares of Common Stock issuable pursuant to such
options shall be the Executive's personal responsibility and not that of the
Corporation.

     The issuance and terms of the options granted to the Executive will be
governed and controlled in accordance with the terms of the Stock Option
Agreement, which shall be entered into by and between the Executive and the
Corporation, and in accordance with the terms and conditions contained in the
Corporation's Stock Option Plan.<Page>

                                                                    EXHIBIT 10.6

                              EMPLOYMENT AGREEMENT

     Employment Agreement, dated October 8, 2001 and effective as of February
28, 2001, (the "Effective Date"), by and between AVAX Technologies, Inc., a
Delaware corporation (the "Corporation"), and Mr. David L. Tousley, an
individual (the "Executive") residing at 14613 Howe Drive, Leawood, Kansas.

                                   WITNESSETH:

     WHEREAS, the Corporation has employed the Executive pursuant to a letter
agreement dated September 13, 1996 and a supplement thereto dated April 7, 1997
(collectively, the "Employment Letter Agreements"), setting forth certain terms
of the Executive's employment; and

     WHEREAS, the Corporation and the Executive wish to amend and restate the
Employment Letter Agreements hereby in their entirety.

     NOW, THEREFORE, in consideration of the foregoing and the mutual promises
and covenants herein contained, it is agreed as follows:

1.   EMPLOYMENT; DUTIES, POWERS AND AUTHORITY

     (a)    The Corporation engages and employs the Executive, and the Executive
hereby accepts engagement and employment as Chief Operating Officer of the
Corporation.

     (b)    The Executive shall perform his duties with all such powers and
authority as appertain to such office in accordance with the Corporation's
by-laws, subject to overall direction consistent with the legal authority of the
Board of Directors of the Corporation (the "Board"), and such duties, powers and
authority shall not be limited or materially changed by the Corporation during
the Employment Period. The Executive shall perform his duties hereunder from the
Corporation's offices and at such other places as shall be necessary according
to the needs, business or opportunities of the Corporation; provided, that the
Executive acknowledges and agrees that the performance by the Executive of his
duties hereunder may require significant domestic and international travel by
the Executive.

     (c)    As Chief Operating Officer, the Executive shall supervise, control
and be responsible for the general management and operations of the Corporation
and have such other executive powers and duties as may from time to time be
prescribed by the Board. The Executive shall report solely to the Board.

     (d)    The Corporation shall cause the Executive to be elected to the Board
at all times during the Employment Period, and the Executive shall serve as a
member of the Board at all times during the Employment Period.

     (e)    The Executive shall devote such of his time and efforts as shall be
necessary to the proper discharge of his duties and responsibilities under this
Agreement. The Executive may engage in other ventures and activities only with
the permission of the Board of Directors of the Corporation.

                                       -1-
<Page>

2.   TERM

     The Executive's employment hereunder shall, unless earlier terminated, be
for a term of three (3) years (the "Initial Period") commencing on the Effective
Date of this Employment Agreement. The Initial Period and any Renewal Periods
(as defined below) are collectively referred to herein as the "Employment
Period". On a date not less than nine (9) months before the end of the
Employment Period, the Company and the Employee shall negotiate in good faith
whether to extend the Term of this Agreement for a further three year period
(the "Renewal Periods") which term(s) are subject to earlier termination as
hereinafter provided.

3.   COMPENSATION

     (a)    As compensation for the performance of his duties on behalf of the
Corporation, the Executive shall be compensated during the Employment Period as
follows:

            (i)    A base salary of not less than $260,000 per annum (the "Base
                   Salary"), subject to annual review commencing 12 months from
                   the Effective Date;

            (ii)   At the sole and absolute discretion of the Board, the
                   Executive may be eligible to receive an annual incentive
                   bonus (targeted to be 40%, the "Target"), beginning with the
                   first anniversary of the Effective Date during the Employment
                   Period. The Board, or a representative of the Board shall
                   meet with the Executive to establish such objectives and
                   performance standards (as the Board determines are to be
                   taken into account in determining the Executive's bonus
                   awards provided for herein. It is assumed that the objectives
                   will include performance criteria for the Corporation and the
                   stock of the Corporation, pursuant to the compensation plan
                   of the Corporation. In consideration of such bonus, the Board
                   may use some or all of the criteria listed in Exhibit I to
                   make its determination. The Target shall be paid only if the
                   Board reasonably determines that the Executive has met all of
                   the agreed to Objectives and performance standards. The bonus
                   may be more or less than Target based upon the degree to
                   which the Objectives and performance standards are met or
                   exceeded, and shall be calculated pursuant to the
                   Compensation Plan of the Corporation as approved by the
                   Compensation Committee of the Board of Directors.

            (iii)  The Corporation shall withhold all applicable federal, state
                   and local taxes, social security and workers' compensation
                   contributions and such other amounts as may be required by
                   law or agreed upon by the parties with respect to the
                   compensation payable to the Executive pursuant to this
                   section 3(a) or otherwise in connection with his employment
                   by the Corporation.

     (b)    The Executive has received options to purchase 765,208 shares of the
Common Stock of the Corporation, par value $.004, according to the Schedule in
Exhibit II. These options shall vest and be exercisable (subject to any resale
restrictions of an underwriter of the Corporation's securities), in accordance
with the provisions and terms of the letter Agreement dated September 13, 1996,
attached as Exhibit III, and in accordance with the terms and conditions
contained in the Corporation's Incentive Stock Option Plan adopted in 1992. In
addition, from time to time, at the discretion of the Board of Directors, the
Executive may be entitled to additional stock options pursuant to the
Corporation's Stock Option Plan.

                                       -2-
<Page>

     (c)    The Corporation shall reimburse the Executive for all normal, usual
and necessary expenses incurred by the Executive in furtherance of the business
and affairs of the Corporation, including reasonable travel and entertainment,
against receipt by the Corporation of appropriate vouchers or other proof of the
Executives expenditures and otherwise in accordance with such Expense
Reimbursement Policy as may from time to time be adopted by the Board of
Directors of the Corporation.

     (d)    The Executive shall be entitled, during the Employment Period, to
not less than four weeks per year of paid vacation time, so long as it does not,
in the discretion of the Board, disrupt operations. The days selected for the
Executive's vacation must be mutually agreeable to the Corporation and the
Executive.

     (e)    During the Employment Period, the Executive shall be entitled to
participate in any group insurance, hospitalization, medical, dental, health and
accident, disability or similar plan or program of Corporation now existing or
established hereafter to the extent that he is eligible under the general
provisions thereof. The Corporation shall at all times during the term of this
Agreement maintain at its expense life insurance on the life of the Executive
with death benefits of at least Nine Hundred Thousand Dollars ($900,000) in the
form of a policy owned by the Executive, the beneficiaries of which are the
Executive's estate or other beneficiaries designated by the Executive. Upon
termination of this Agreement, the Corporation shall transfer the policy and all
accrued benefits thereunder to the Executive at no cost to the Executive such
that thereafter the Executive may maintain the full benefits of the policy by
paying premiums that become due for periods after termination at levels not
greater than those being paid by the Corporation during the term of this
Agreement.

     (f)    The Executive shall continue to be entitled to receive his salary
and benefits hereunder during any period (up to a maximum of 10 business days
(or such greater number of days as are consistent with the Corporation's sick
leave policies) per year) during which he is unable to perform his duties
hereunder because of ill health or Disability (as defined below).

     (g)    Subject to paragraphs (d) through (f) of Section 10 below, the
Executive must be an employee of the Corporation at the time that any
compensation is due in order to receive such compensation.

4.   REPRESENTATIONS AND WARRANTIES BY EXECUTIVE AND CORPORATION

     The Executive hereby represents and warrants to the Corporation as follows:

     (a)    Neither the execution and delivery of this Agreement nor the
performance by the Executive of his duties and other obligations hereunder
violate or will violate any statute, law, determination or award, or conflict
with or constitute a default under (whether immediately, upon the giving of
notice or lapse of time or both) any prior employment agreement, contract, or
other instrument to which the Executive is a party or by which he is bound.

     (b)    The Executive has the full right, power and legal capacity to
execute and deliver this Agreement and to perform his duties and other
obligations hereunder. This Agreement constitutes the legal, valid and binding
obligation of the Executive enforceable against him in accordance with its
terms. No approvals or consents of any persons or entities are required for the
Executive to execute and deliver this Agreement or perform his duties and other
obligations hereunder.

     The Corporation hereby represents and warrants to the Executive as follows:

                                       -3-
<Page>

     (a)    The Corporation is a corporation duly organized, validly existing
and in good standing under the laws of the State of Delaware, which has all
requisite corporate power and authority to own its properties and conduct its
business in the manner presently contemplated.

     (b)    The Corporation has full power and authority to enter into this
Agreement and to incur and perform its obligations hereunder. This Agreement
constitutes the legal, valid and binding obligation of the Corporation
enforceable against the Corporation in accordance with its terms.

     (c)    The execution, delivery and performance by the Corporation of this
Agreement does not conflict with or result in a breach or violation of or
constitute a default under (whether immediately, upon the giving of notice or
lapse of time or both) the certificate of incorporation or by-laws of the
Corporation, or any agreement or instrument to which the Corporation is a party
or by which the Corporation or any of its properties may be found or affected.

5.   NON-COMPETITION

     (a)    The Executive understands and recognizes that his services to the
Corporation are special and unique and agrees that, during the Employment Period
and for a period of two years from the date of termination of his employment for
cause hereunder, he shall not in any manner, directly or indirectly, on behalf
of himself or any person, firm, partnership, joint venture, corporation or other
business entity ("Person"), enter into or engage in any business directly
competitive with the Corporation's business or relating to immunotherapies for
the treatment of cancer, or other therapies, treatments or matters within the
scope of, or research and development relating to, the Corporation's business,
either as an individual for his own account, or as a partner, joint venturer,
executive, agent, consultant, salesperson, officer, director or shareholder of a
Person operating or intending to operate within the area that the Corporation
is, at the date of termination, conducting its business (collectively,
"Restricted Business"). This paragraph 5(a) shall be null and void if the
Executive is terminated by the Corporation for any reason other than that
pursuant to Section 10(a)(iii).

     (b)    In the event that the Executive breaches any provisions of this
Section 5 or there is a threatened breach, then, in addition to any other rights
which the Corporation may have, the Corporation shall be entitled, without the
posting of a bond or other security, to injunctive relief to enforce the
restrictions contained herein. In the event that an actual proceeding is brought
in equity to enforce the provisions of this Section 6, the Executive shall not
urge as a defense that there is an adequate remedy at law nor shall the
Corporation be prevented from seeking any other remedies that may be available.

6.   CONFIDENTIAL INFORMATION

     (a)    The Executive agrees that during the course of his employment and
for a period of three years after termination, he will not disclose or make
accessible to any other person, the Corporation's products, services and
technology, both current and under development, promotion and marketing
programs, lists, trade secrets and other confidential and proprietary business
information of the Corporation or any of its clients except to the extent the
same have become generally known to the public other than through a breach of
this Section 6. The Executive agrees: (i) not to use any such information for
himself or others during such three-year period; and (ii) not to take any such
material or reproductions thereof from the Corporation's facilities at any time
during his employment by the Corporation, except as required in the Executive's
duties to the Corporation. The Executive agrees immediately to return all such
material and reproductions thereof in his possession to the Corporation upon
request and in any event upon termination of employment.

                                       -4-
<Page>

     (b)    Except with prior written authorization by the Corporation, the
Executive agrees not to disclose or publish any of the confidential, technical
or business information or material of the Corporation, its clients or any other
party to whom the Corporation owes an obligation of confidence, at any time
during or for a period of three (3) years after his employment with the
Corporation.

7.   OWNERSHIP OF PROPRIETARY INFORMATION

     (a)    The Executive agrees that all information that has been created,
discovered or developed by the Corporation, its subsidiaries, affiliates,
successors or assigns (collectively, the "Affiliates") (including, without
limitation, information relating to the development of the Corporation's
business created by, discovered by, developed by or made known to the
Corporation or the Affiliates by Executive during the Employment Period and
information relating to Corporation's customers, suppliers, consultants, and
licensees) and/or in which property rights have been assigned or otherwise
conveyed to the Corporation or the Affiliates, shall be the sole property of the
Corporation or the Affiliates, as applicable, and the Corporation or the
Affiliates, as the case may be, shall be the sole owner of all patents,
copyrights and other rights in connection therewith, including but no limited to
the right to make application for statutory protection. All of the
aforementioned information is hereinafter called "Proprietary Information". By
way of illustration but without limitation, Proprietary Information shall
include all discoveries, structures, inventions, designs, ideas, works of
authorship, copyrightable works, trademarks, copyrights, formulas, data,
know-how, show-how, improvements, inventions, product concepts, techniques,
information or statistics contained in, or relating to, marketing plans,
strategies, forecasts, blueprints, sketches, records, notes, devices, drawings,
customer lists, patent applications, continuation applications,
continuation-in-part applications, file wrapper continuation applications and
divisional applications and information about the Corporation's or the
Affiliates' employees and/or consultants (including, without limitation, the
compensation, job responsibility and job performance of such employees and/or
consultants).

     (b)    The Executive further agrees that at all times, both during the
Employment Period and after the termination of this Agreement, he will keep in
confidence and trust all Proprietary Information, and he will not use or
disclose any Proprietary Information or anything directly relating to it without
the written consent of the Corporation or the Affiliates, as appropriate, except
as may be necessary in the ordinary course of performing his duties hereunder
and except for academic, non-commercial research purposes with the prior written
approval of the Board of Directors. The Executive acknowledges that the
Proprietary Information constitutes a unique and valuable asset of the
Corporation and each Affiliate acquired at great time and expense, which is
secret and confidential and which will be communicated to the Executive, if at
all, in confidence in the course of his performance of his duties hereunder, and
that any disclosure or other use of the Proprietary Information other than for
the sole benefit of the Corporation or the Affiliates would be wrongful and
could cause irreparable harm to the Corporation or the Affiliates, as the case
may be.

            Notwithstanding the foregoing, the parties agree that, at all such
times, the Executive is free to use (i) information in the public domain not as
a result of a breach of this Agreement, (ii) information lawfully received from
a third party and (iii) the Executive's own skill, knowledge, know-how and
experience to whatever extent and in whatever way he wishes, in each case
consistent with his obligations as the Executive and that, at all times, the
Executive is free to conduct any non-commercial research not relating to the
Corporation's business.

8.   DISCLOSURE AND OWNERSHIP OF INVENTIONS

     (a)    During the Employment Period, the Executive agrees that he will
promptly disclose to the Corporation, or any persons designated by the
Corporation, all improvements, inventions, designs, ideas,

                                       -5-
<Page>

works of authorship, copyrightable works, discoveries, trademarks, copyrights,
trade secrets, formulas, processes, structures, product concepts, marketing
plans, strategies, customer lists, information about the Corporation's or the
Affiliates' employees and/or consultants (including, without limitation, job
performance of such employees and/or consultants), techniques, blueprints,
sketches, records, notes, devices, drawings, know-how, data, whether or not
patentable, patent applications, continuation applications, continuation-in-part
applications, file wrapper continuation applications and divisional
applications, made or conceived or reduced to practice or learned by him, either
alone or jointly with others, during the Employment Period (all said
improvements, inventions, designs, ideas, works of authorship, copyrightable
works, discoveries, trademarks, copyrights, trade secrets, formulas, processes,
structures, product concepts, marketing plans, manufacturing or other
strategies, customer lists, information about the Corporation's or the
Affiliates' employees and/or consultants, techniques, blueprints, sketches,
records, notes, devices, drawings, know-how, data, patent applications,
continuation applications, continuation-in-part applications, file wrapper
continuation applications and divisional applications shall be collectively
hereinafter called "Inventions").

     (b)    The Executive agrees that all Inventions shall be the sole property
of the Corporation to the maximum extent permitted by applicable law and to the
extent permitted by law shall be "works made for hire" as that term is defined
in the United States Copyright act (17 USCA, Section 101). The Corporation shall
be the sole owner of all patents, copyrights, trade secret rights, and other
intellectual property or other rights in connection therewith. The Executive
hereby assigns to the Corporation all right, title and interest he may have or
acquire in all Inventions. The Executive further agrees to assist the
Corporation in every possible way (but at the Corporation's expense) to obtain
and from time to time, enforce patents, copyrights or other rights on said
Inventions in any and all countries, and to that end the Executive will execute
all documents necessary:

            (i)    to apply for, obtain and vest in the name of the Corporation
                   alone (unless the Corporation otherwise directs) letters
                   patent, copyrights or other analogous protection in any
                   country throughout the world and when so obtained or vested
                   to renew and restore the same; and

            (ii)   to defend any opposition proceedings in respect of such
                   applications and any opposition proceedings or petitions or
                   applications for revocation of such letters, patent,
                   copyright or other analogous protection.

     (c)    The Executive's obligation to assist the Corporation in obtaining
and enforcing patents and copyrights for the Inventions in any and all countries
shall continue beyond the Employment Period, but the Corporation agrees to
compensate the Executive a reasonable rate after the expiration of the
Employment Period for time actually spent by the Executive at the Corporation's
request on such assistance.

9.   NON-SOLICITATION

     During the Employment Period, and for 18 months thereafter, Executive shall
not, directly or indirectly, without the prior written consent of the
Corporation (i) solicit or induce any employee of the Corporation or any
Affiliate to leave the employ of the Corporation or any Affiliate or (ii) hire
for any purpose any present or former employee of the Corporation or any
Affiliate, unless said employee has been terminated by the Corporation for any
reason or the employee has terminated his or her employment for cause.

                                       -6-
<Page>

10.  TERMINATION

     (a)    The Executive's Employment Period hereunder shall begin on the
Effective Date and shall continue for the period set forth in Section 2 hereof
unless sooner terminated upon the first to occur of the following events:

            (i)    The death of the Executive;

            (ii)   The Disability (as defined below in Section 10(b)) of the
                   Executive;

            (iii)  Termination by the Board of Directors of the Corporation for
                   "Just Cause", provided that the Corporation shall have given
                   proper notice thereof, and the Executive shall have had at
                   least a thirty (30) day period to cure such "Just Cause". For
                   the Purposes of this Agreement, any of the following actions
                   by the Executive shall constitute "Just Cause":

                   (A) Material breach by the Executive of Sections 5, 6, 7, 8,
                       or 9 of this Agreement;

                   (B) Material breach by the Executive of any provision of this
                       Agreement other than Sections 5, 6, 7, 8, or 9 which is
                       not cured by the Executive within 30 days of written
                       notice thereof from the Corporation;

                   (C) Negligent performance by the Executive of his duties as
                       Chief Operating Officer of the Corporation, as determined
                       by the Board, after notice to the Executive and an
                       opportunity for the Executive to be heard by the Board;

                   (D) Any misconduct or omission on the part of the Executive
                       intended to cause harm to the Corporation; or

                   (E) The conviction of the Executive of (i) any felony or (ii)
                       any other crime involving moral turpitude;

            (iv)   Termination by the Executive for "Good Reason". Any of the
                   following actions or omissions by the Corporation shall
                   constitute "Good Reason", provided that the Executive shall
                   have given proper notice thereof, and the Corporation shall
                   have had at least a thirty (30) day period to cure such "Good
                   Reason":

                   (A) Material breach by the Corporation of any provision of
                       this Agreement that is not cured by the Corporation
                       within 30 days of written notice thereof from the
                       Executive to the Corporation, specifying in reasonable
                       detail the basis for such claimed breach;

                   (B) The failure of the Corporation to provide the Executive
                       with a position, authority or duties at least equivalent
                       to the position, authority or duties (other than those
                       relating to the Board of Directors or any committee
                       thereof) previously held by the Executive during the
                       Employment Period, or any reduction of the Compensation
                       paid by the Corporation to the Executive or any material
                       reduction of the benefits given by the Corporation to the
                       Executive, unless such reduction is deemed necessary

                                       -7-
<Page>

                       by the Board with the consent of the Executive, if such
                       circumstance is not remedied within (15) business days
                       after written notice from the Executive to the
                       Corporation.

            (v)    A Change of Control which shall be deemed to occur upon
                   either of the following:

                   (A) The sale by the Corporation of all or substantially all
                       of its assets to any person (as such term is used in
                       Sections 13(d) and 14(d) of the Securities and Exchange
                       Act of 1934), the consolidation of the Corporation with
                       any person, or the merger of the Corporation with any
                       person as a result of which merger the Corporation is no
                       longer the surviving entity, or if the Survivor, the
                       Corporation is owned by a parent company, unless,
                       following such consolidation at least a majority of the
                       members of the Board of Directors of the surviving entity
                       or transferee are members of the Board of Directors of
                       the Corporation at the time of the initial action of the
                       Board of Directors providing for such consolidation, or

                   (B) The sale or transfer by one or more of the Corporation's
                       shareholders, in one or more transactions, related or
                       unrelated to one or more persons under circumstances
                       whereby any person and its affiliates (as hereafter
                       defined) shall own as a result of such sale or transfer
                       thereafter, at least one half of the outstanding shares
                       of the Corporation.

                   Nothing contained in the definition of Change of Control
                   shall limit or restrict the right of the Executive, in his
                   capacity as a member of the Board, from participating in any
                   discussions or voting on any matter referred to in said
                   definition at any meeting of the Board. An "Affiliate" shall
                   mean any person that directly or indirectly, through one or
                   more intermediaries, controls, or is controlled by, or under
                   common control with, any other person.

     (b)    For purposes hereof, a "Disability" of the Executive shall be deemed
to have occurred in the event (i) the Executive is absent from work or otherwise
substantially unable to assume his normal duties for a period of 30 successive
days or an aggregate of 60 days during any 12-month period because of physical
or mental disability, accident, illness or other cause other than approved
vacation or leave of absence or (ii) the Executive is deemed by a licensed
physician designated by the Corporation and reasonably acceptable to the
Executive to have a permanent disability such that Executive will be unable to
perform his duties under this agreement. The Corporation shall have the right to
have the Executive examined by a competent physician for purposes of determining
his physical or mental incapacity.

     (c)    Upon termination by Corporation pursuant to either subparagraphs
(i), (ii), (iii) and (iv) of paragraph (a) above or by Executive other than
pursuant to subparagraph (iv) of paragraph (a) above, the Executive (or his
estate in the event of termination pursuant to subparagraph (ii)), shall be
entitled to receive the Base Salary accrued but unpaid as of the date of
termination.

     (d)    Upon termination by the Corporation (other than following a Change
of Control) for any reason other than as set forth in subparagraphs (i), (ii) or
(iii) of paragraph (a) above or by the Executive for any reason set forth in
subparagraphs (iv) of paragraph (a) above, then the Corporation shall continue
to pay the Executive, as the Executive's sole damages for such termination, for
one year following such termination, the Base Salary (at the rate in effect at
the date of termination) which the Executive would

                                       -8-
<Page>

have received during the one year period following the termination of this
Agreement had his employment not been so terminated; provided that on the date
of such termination, the Executive shall be paid a lump sum equal to one times
the annual Base Salary without set-off for any salary earned from alternative
employment. In addition, any stock options granted to the Executive, including,
but not limited to Section 3(b), shall continue to vest according to the
provisions of Section 3(b) during such one-year severance period.

     (e)    Upon termination, following a Change of Control, by the Corporation
(other than as set forth in subparagraph (i), (ii) or (iii) of paragraph (a)
above) or by the Executive for any reason set forth in subparagraphs (iv) of
paragraph (a) above, then the Corporation shall pay the Executive, as the
Executive's sole damages for such termination, a lump sum payment equal to two
times the Base Salary at the higher of the rate in effect at the date of
termination or the rate in effect on the date of the Change of Control. Such
amount(s) shall not be set-off against amounts earned from alternative
employment. In addition, any stock options granted to the Executive, including,
but not limited to Section 3(b), shall thereupon become immediately vested.

     (f)    It shall be a condition to the Executive's right to receive the
benefits provided for in paragraphs (d) through (f) of Section 3 above that the
Executive shall have delivered to the Corporation a general release dated as of
the date of termination of the Executive's employment hereunder.

11.  INDEMNIFICATION

     The Corporation shall indemnify and hold the Executive harmless to the
fullest extent permitted by the General Corporation Law of the State of
Delaware, as amended from time to time, for all amounts, (including without
limitation, judgements, fines, settlement payments, expenses and attorney's
fees) incurred or paid by the Executive in connection with any action, suit,
investigation or proceeding arising out of or relating to the performance by the
Executive of services for, or acting by the Executive as a director, officer or
employee of, the Corporation or any other person or enterprise at the
Corporation's request, and shall to the fullest extent permitted by the General
Corporation Law of the State of Delaware, as amended from time to time, advance
all expenses incurred or paid by the Executive in connection with, and until
disposition of, any action, suit, investigation or proceeding arising out of or
relating to the performance by the Executive of services for, or acting by the
Executive as a director, officer or employee of, the Corporation or any other
person or enterprise at the Corporation's request.

12.  INSURANCE

     If requested by the Corporation, the Executive agrees to cooperate with the
Corporation in obtaining for the Corporation's benefit, at the Corporation's
expense, life insurance on his life. Such cooperation shall include completing
and signing such forms or applications, undergoing physical examinations, and
such other acts as may be required in order to obtain such insurance.

13.  NOTICES

     Any notice or other communication under this Agreement shall be in writing
and shall be deemed to have been given: when delivered personally against
receipt therefor; one (1) day after being sent by Federal Express or similar
overnight delivery; or three (3) days after being mailed registered or certified
mail, postage prepaid, return receipt requested, to either party at the address
set forth below, or to such other address as such party shall give by notice
hereunder to the other party.

                                      -9-
<Page>

IF TO CORPORATION:                           IF TO EXECUTIVE:

AVAX Technologies, Inc.                      David L. Tousley
4520 Main Street, Suite 930                  14613 Howe Drive
Kansas City, MO 64111                        Leawood, KS 66224

With a copy to:
Shook Hardy & Bacon
Attention: Kevin R. Sweeney, Esq.
1010 Grand Blvd.
Kansas City, MO 64106

14.  SEVERABILITY OF PROVISIONS

     If any provision of this Agreement shall be declared by a court of
competent jurisdiction to be invalid, illegal or incapable of being enforced in
whole or in part, the remaining conditions and provisions or portions thereof
shall nevertheless remain in full force and effect and enforceable to the extent
they are valid, legal and enforceable, and no provision shall be deemed
dependent upon any other covenant or provision unless so expressed herein.

15.  ENTIRE AGREEMENT; MODIFICATION

     (a)    This Agreement and the agreements and instruments referenced in
Section 3(b) hereof contain the entire agreement of the parties relating to the
subject matter hereof and supersede in their entirety the Employment Letter
Agreements, and the parties hereto have made no agreements, representations or
warranties relating to the subject matter of this Agreement which are not set
forth herein or in the agreements and instruments referenced in said Section
3(b). No modification of this Agreement shall be valid unless made in writing
and signed by the parties hereto.

     (b)    The Executive acknowledges that any cash and non-cash compensation
received by him prior to the execution of this Agreement shall be applied to the
obligations of the Corporation hereunder and that the execution of this
Agreement after the Effective Date is not intended to entitle the Executive to
any greater compensation than was originally set forth in the Employment Letter
Agreements.

16.  BINDING EFFECT

     The rights, benefits, duties and obligations under this Agreement shall
inure to, and be binding upon, the Corporation, its successors and assigns, and
upon the Executive and his legal representatives. This Agreement constitutes a
personal service agreement, and the performance of the Executive's obligations
hereunder may not be transferred or assigned by the Executive.

17.  NON-WAIVER

     The failure of either party to insist upon the strict performance of any of
the terms, conditions and provisions of this Agreement shall not be construed as
a waiver or relinquishment of future compliance therewith, and said terms,
conditions and provisions shall remain in full force and effect. No waiver of
any term or condition of this Agreement on the part of either party shall be
effective for any purpose whatsoever unless such waiver is in writing and signed
by such party.

                                      -10-
<Page>

18.  REMEDIES FOR BREACH

     The Executive understands and agrees that any breach of Sections 5, 6, 7, 8
and 9 of this Agreement by the Executive could cause irreparable damage to the
Corporation and to the Affiliates, and that monetary damages alone would not be
adequate and, in the event of such breach, the Corporation shall have, in
addition to any and all remedies of law, the right to an injunction, specific
performance or other equitable relief to prevent or redress the violation of the
Executive's obligations under such Sections.

19.  GOVERNING LAW

     This Agreement shall be governed by, and construed and interpreted in
accordance with, the laws of the State of Delaware without regard to principles
of conflict of laws.

20.  HEADINGS

     The headings of paragraphs are inserted for convenience and shall not
affect any interpretation of this Agreement.

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of
the day and year first above written.

                                           /s/ David L. Tousley
                                         ---------------------------------------
                                         David L. Tousley

                                         AVAX TECHNOLOGIES, INC.

                                  By:      /s/ John Prendergast
                                         ---------------------------------------
                                         Name:  John Prendergast
                                         Title: Director

                                      -11-
<Page>

                                    EXHIBIT I

    SOME CRITERIA FOR ASSESSMENT OF CHIEF OPERATING OFFICER PERFORMANCE BONUS

       o   ESTABLISHMENT OF STRATEGIC PLAN ANNUALLY
       o   IMPLEMENTATION OF THE COMPANY'S STRATEGIC PLAN
       o   ADVANCEMENT OF COMPANY TECHNOLOGIES ACCORDING TO THE STRATEGIC PLAN
       o   ACHIEVEMENT OF CORPORATE ALLIANCES
       o   ACHIEVEMENT OF CORPORATE ANNUAL OBJECTIVES
       o   INCREASE IN MARKET CAP OF THE COMPANY
       o   SUFFICIENT CAPITALIZATION OF THE COMPANY TO ENSURE SHORT TERM FUNDING
           TO IMPLEMENT STRATEGIC PLAN

                                      -12-
<Page>

                                   EXHIBIT II
                             INCENTIVE STOCK OPTIONS

<Table>
<Caption>
SHARES         ISSUE DATE         PRICE           EXPIRATION
----------------------------------------------------------------
<S>             <C>              <C>              <C>
125,000         10-01-96         $  1.00          10-01-03

 60,000         07-10-97         $  4.50          07-10-04

 50,000         10-07-98         $  1.25          10-07-05

 48,386         11-16-99         $ 2.938          11-16-06

 81,718         11-22-99         $ 2.938          11-22-06

 30,000         12-26-00         $ 2.938          12-26-07

150,000         03-26-01         $ 0.906          03-26-08

220,104         10-05-01         $  1.00          10-05-08
</Table>

                                      -13-

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