Document:

EX-10.4

 Exhibit 10.4 

CVB FINANCIAL CORP. 

2018 EQUITY INCENTIVE PLAN 

FORM OF NOTICE OF GRANT 

AND 
 RESTRICTED
STOCK UNIT AGREEMENT 
 You have been granted Restricted Stock Units (“RSUs”) with respect to the number of shares of common stock
of CVB Financial Corp, (the “Company”) set forth below (“Shares”), subject to the terms and conditions of the CVB Financial Corp. 2018 Equity Incentive Plan (“Plan”), and this Notice of Grant and
Restricted Stock Unit Agreement including the attachments hereto (collectively, “Notice and Agreement”). Unless otherwise defined in the Notice and Agreement, terms with initial capital letters shall have the meanings set forth in
the Plan. 
 Participant:     

Address:     
 Number of Shares subject to
RSUs Granted: 
  

			
	 Grant Date:
	  	
[                  
              ], 20        

		
	 Period of Restriction, Vesting of RSUs and

Delivery of Shares (see Sections 2 and 3 of
 attached Restricted
Stock Unit Agreement)
	  	 The Period of Restriction, during which the RSUs shall vest, shall be for a period of
                             years following the Grant Date. The RSUs shall vest as to the following
numbers of Shares and on the following schedule (Vesting Dates):

                          
   Shares on [date no earlier than one year after Grant Date]

                          
   additional Shares on [date]
                             additional Shares on
[date]
                             additional Shares on [date]

 By signing below, you accept this grant of RSUs and you hereby represent that you: (i) agree to the terms and conditions
of this Notice and Agreement and the Plan; (ii) have reviewed the Plan and the Notice and Agreement in their entirety, and have had an opportunity to obtain the advice of legal counsel and/or your tax advisor with respect thereto;
(iii) fully understand and accept all provisions hereof; (iv) agree to accept as binding, conclusive, and final all of the Administrator’s decisions regarding, and all interpretations of, the Plan and the Notice and Agreement; and
(v) agree to notify the Company upon any change in your home address indicated above. 
  

	
	AGREED AND ACCEPTED:
	
	Signature:
	Print Name:

 CVB FINANCIAL CORP. 

2018 EQUITY INCENTIVE PLAN 

RESTRICTED STOCK UNIT AGREEMENT 

1.            Grant of Restricted Stock Units. The Company has granted to you Restricted
Stock Units (“RSUs”) with respect to the number of Shares specified in the Notice of Grant on the preceding page (“Notice of Grant”), subject to the following terms and conditions. In consideration of such grant,
you agree to be bound by such terms and conditions, and by the terms and conditions of the Plan. 

2.            Period of Restriction. During the Period of Restriction specified in the
Notice of Grant, the RSUs shall not be vested and the Participant shall have no rights to or with respect to the Shares subject to the RSUs. The Period of Restriction shall expire and the RSUs shall lapse as to the Shares in the amount(s) and on the
date(s) specified in the Notice of Grant (each, a “Vesting Date”); provided, however, that no RSUs shall vest on any Vesting Date if the Participant has ceased Continuous Status as an Employee, Consultant or Director on or prior to
such date. 
 3.            Delivery of Shares. As soon as reasonably practicable
following each Vesting Date, or any other vesting event specified herein or in the Plan, but in no event later than the 15th day of the third month following the later of the Company’s or the Participant’s tax year end of the year in which
the Vesting Date or vesting event occurs, the Company shall cause to be delivered to the Participant the number of Shares then vesting in accordance with the provisions of this Agreement. No fractional Shares shall be delivered to the Participant.

 4.            Restriction on Transfer. Neither the RSUs nor any beneficial interest
therein shall be transferred, encumbered or otherwise disposed of in any way other than by will or the laws of descent and distribution or pursuant to a “domestic relations order” (as defined in Code Section 414(p)(1)(B)). In
addition, as a condition to any transfer of Shares issued with respect to RSUs that have vested, the Company may, in its discretion, require: (i) that the Shares shall have been duly listed upon any national securities exchange or automated
quotation system on which the Company’s common stock may then be listed or quoted; (ii) that either (a) a registration statement under the Securities Act of 1933, as amended (“Securities Act”) with respect to the
Shares shall be effective, or (b) in the opinion of counsel for the Company, the proposed purchase shall be exempt from registration under the Securities Act and the Participant shall have entered into agreements with the Company as reasonably
required; and (iii) fulfillment of any other requirements deemed necessary by counsel for the Company to comply with Applicable Law. 

5.            Restrictive Covenants. Participant shall not, for a period of twelve
(12) months following the termination of his or her employment by (or other business relationship with) the Company or any of its affiliates: 

(a)            directly or indirectly (i) Solicit or assist any other
individual or entity in Soliciting any Customer or Prospective Customer for the purpose of performing or providing any financial or banking services that a national banking association, bank holding company, state bank, savings and loan association,
or other regulated financial institution is permitted by law to 

  
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conduct or furnish (“Banking Services”) as of the date of Participant’s termination of employment (or other business relationship) by using any Confidential Information (as
defined in Section 6(a) below); or (ii) interfere with or damage (or attempt to interfere with or damage) any relationship and/or agreement between the Company or any of its affiliates and a Customer or Prospective Customer by using any
Confidential Information; or 
 (b)            directly or indirectly Solicit,
or assist any other individual or entity in Soliciting any person then currently employed by (or in a business relationship with) the Company or its affiliates, or any person employed by (or in a business relationship with) the Company, its
affiliates and/or their predecessors within twelve (12) months of the end of Participant’s employment (or other business relationship) with the Company or its affiliates, to terminate his, her business relationship, employment, or other
association with the Company or its affiliates. 
 (c)            For purposes
of this Notice and Agreement: 
 (i)            “Customer”
shall mean any person, firm, corporation or other organization for whom the Company, its affiliates and/or their predecessors provided Banking Services within a 12-month period before or after the date on
which Participant’s employment (or other business relationship) with the Company or its affiliates terminated. 

(ii)            “Prospective Customer” shall mean any person,
firm, corporation or other organization with whom the Participant has had any negotiations or discussions regarding the possible performance of Banking Services on behalf of the Company or its affiliates within the twelve (12) months preceding
the termination of the Participant’s employment (or other business relationship) with the Company. 

(iii)            “Solicit” shall mean to have any direct or
indirect communications of any kind whatsoever, which invites, advises, encourages or requests that any person or entity take or refrain from taking any action in any manner. 

(d)            The obligations set forth in this Section 5 shall survive the
termination of Participant’s employment (or other business relationship) and expiration of the term of this Notice and Agreement. 

6.            Property Rights, Confidential Information and Trade Secrets of the Company.

 (a)            Participant understands that in the course of
Participant’s employment with the Company or its affiliates, Participant will or may have access to and become informed of confidential, proprietary and/or trade secret information concerning the Company or its affiliates that is not generally
known to the public or the competitors of the Company or its affiliates (collectively referred to as “Confidential Information”) including but not limited to: 

(i)            Information regarding the Company’s and/or its
affiliates’ general business operations (including, without limitation, financial information, business plans, organizational structure, policies, strategic planning, sales, marketing strategies, distribution methods, data processing and other
systems, personnel policies and compensation plans and arrangements); 

  
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 (ii)            Information
prepared or compiled by the Company or its affiliates regarding its Customers or Prospective Customers (including, without limitation, information contained in account analysis reports and credit memoranda, deposit and account activity information,
lending terms and rates offered to specific Customers and/or Prospective Customers of the Company or its affiliates, loan agreements, commitment letters, audit information, and information relating to Banking Services offered by the Company or its
affiliates to Customers); 
 (iii)            Information, knowledge, formulas,
or data of a technical nature (including, without limitation, methods, know-how, processes, discoveries, or research projects); 

(iv)            Information, knowledge or data relating to future developments
(including, without limitation, research and development, future marketing or merchandising); 

(v)            Any and all Customers and Prospective Customers’ names,
addresses and other contact information (such as telephone numbers and e-mail addresses), Customer preferences and accounts, lists, suppliers lists and advertising lists of the Company or its affiliates; and

 (vi)            Any and all employee lists, employee identities, directories
and information (including but not limited to information regarding employees’ salaries, commissions and other benefits, levels of knowledge, performance, experience and expertise, strengths and weaknesses, and special talents). 

(b)            Participant understands and agrees that such Confidential
Information constitutes a valuable competitive asset of the Company and its affiliates and that it is and shall remain the exclusive property of the Company and/or its affiliates. 

(c)            Participant understands and agrees that, except in the course of
Participant’s regular authorized duties on behalf of the Company or its affiliates, Participant will keep all Confidential Information in strict confidence during the term of Participant’s employment with the Company or its affiliates and
thereafter, and Participant will never directly or indirectly make known, divulge, reveal, furnish, make available, disclose, or use any Confidential Information, whether prepared by Participant or otherwise coming into Participant’s
possession, custody, or control. 
 (d)            The obligations set forth in
this Section 6 will survive the termination of Participant’s employment (or other business relationship) and any expiration of the term of this Notice and Agreement. 

7.            Injunctive Relief. Participant understands and agrees that the breach or
threatened breach of the agreements contained in Sections 5 and 6 (the “Restrictive Covenants”), above, would give rise to irreparable injury to the Company and/or its affiliates which injury would be inadequately compensable in
money damages. Accordingly, the Company and/or its affiliates may seek and obtain a restraining order and/or injunction prohibiting the breach or threatened breach of the Restrictive Covenants, in addition to and not in limitation of any other legal
remedies which may be available. Participant further understands and agrees that the covenants set forth in the Restrictive Covenants are necessary for the protection of the Company’s and/or its affiliates’ legitimate business interests
and are reasonable in scope and content. 

  
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 8.            Shareholder Rights; Dividend
Equivalents. The Participant shall have no rights as a shareholder of the Company with respect to any Shares subject to the RSUs until the RSUs have vested and the Shares have been issued to the Participant. No adjustment shall be made for
ordinary or extraordinary dividends (whether in currency, securities or other property), distributions, or other rights (including, but not limited to, the right to vote) for which the record date is prior to the date such Shares are issued, except
as provided in the Plan. [However, the Participant shall be paid dividend equivalents with respect to the RSUs equal to any ordinary dividends paid on Shares from the date of grant of the RSUs through the date Shares are issued, which dividend
equivalents shall be paid in the same form of payment (cash or Shares) as ordinary dividends are paid to shareholders of record during such period.] If, from time to time prior to the Vesting Date, there is (i) any extraordinary stock dividend,
stock split or other change in the Shares, or (ii) any merger or sale of all or substantially all of the assets or other acquisition of the Company, any and all new, substituted or additional securities to which the Participant may become
entitled by reason of the RSUs shall be immediately subject to the terms of this Notice and Agreement and included thereafter as “Shares” subject to this Notice and Agreement. 

9.            Legends. The share certificate evidencing the Shares, if any, issued pursuant
to the RSUs granted hereunder shall bear appropriate legends for compliance with applicable federal and state securities laws. 

10.            U.S. Tax Consequences. The Participant has reviewed with the
Participant’s own tax advisors the federal, state, local and foreign tax consequences of receiving RSUs and the transactions contemplated by this Notice and Agreement. The Participant is relying solely on such advisors and not on any statements
or representations of the Company or any of its employees or agents. The Participant understands that the Participant (and not the Company) shall be responsible for the Participant’s own tax liability that may arise as a result of the
transactions contemplated by this Notice and Agreement. The Participant understands that under the U.S. Internal Revenue Code of 1986, as amended (the “Code”), the Participant will be taxed as ordinary income on the fair market
value of the Shares received upon vesting of the RSUs as of the Vesting Date. 

11.            Compliance with Other Laws and Regulations. Notwithstanding anything to the
contrary in this Notice and Agreement, the grant and exercise of RSUs hereunder, and the obligation of the Company to sell and deliver shares under such RSUs, shall be subject to all applicable federal and state laws, rules and regulations and to
such approvals by any governmental or regulatory agency as may be required including the rules and regulations of the Securities and Exchange Commission and the rules of any exchange or any quotation system on which the Company’s common stock
may then be listed. Without limitation of the foregoing, Participant agrees and acknowledges that the sale of the shares underlying such RSUs, shall be made in compliance with the Company’s then applicable Insider Trading Policy and all other
applicable federal and state securities laws. The Company shall not be required to issue or deliver any certificates for shares of its common stock prior to the completion of any registration or qualification of such shares under any federal or
state law or issuance of any ruling or regulation of any government body which the Company shall, in its sole discretion, determine to be necessary or advisable. 

  
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 12.            General. 

(a)            This Notice and Agreement shall be governed by and construed under
the laws of the State of California and applicable federal law. The Notice and Agreement and the Plan, which is incorporated herein by reference, represents the entire agreement between the parties with respect to the Restricted Stock Units granted
to the Participant. In the event of a conflict between the terms and conditions of the Plan and the terms and conditions of this Notice and Agreement, the terms and conditions of the Plan shall prevail. To the extent that Participant has
entered into any agreement to arbitrate claims with the Company, such agreement to arbitrate claims, which is incorporated herein by reference, shall apply to any and all disputes between Participant and the Company arising out of or relating to the
Notice and Agreement and the Plan. 
 (b)            Any notice, demand or
request required or permitted to be delivered by either the Company or the Participant pursuant to the terms of this Notice and Agreement shall be in writing and shall be deemed given when delivered personally, deposited with an international
courier service, or deposited in the U.S. Mail, First Class with postage prepaid, and addressed to the parties at the addresses set forth in the Notice of Grant, or such other address as a party may request by notifying the other in writing.

 (c)            The rights of the Company under this Notice and Agreement and
the Plan shall be transferable to any one or more persons or entities, and all covenants and agreements hereunder shall inure to the benefit of, and be enforceable by the Company’s successors and assigns. The rights and obligations of the
Participant under this Notice and Agreement may only be assigned with the prior written consent of the Company. 

(d)            The Participant agrees upon request to execute any further
documents or instruments necessary or desirable to carry out the purposes or intent of this Notice and Agreement. 

(e)            PARTICIPANT ACKNOWLEDGES AND AGREES THAT THE RESTRICTED STOCK
UNITS AND ANY SHARES TO BE DELIVERED PURSUANT TO THIS AGREEMENT SHALL BE EARNED ONLY BY CONTINUING SERVICE AS AN EMPLOYEE, CONSULTANT OR DIRECTOR, AND NOT THROUGH THE ACT OF BEING HIRED, APPOINTED OR OBTAINING RESTRICTED STOCK UNITS HEREUNDER. 

##### 

  
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 CONSENT OF SPOUSE 

I,
                                , spouse of
                                , have read and approve the foregoing Notice of
Grant and Restricted Stock Unit Agreement (the “Notice and Agreement”). In consideration of the Company’s grant to my spouse of the Restricted Stock Units for Shares of CVB Financial Corp. as set forth in the Notice and
Agreement, I hereby appoint my spouse as my attorney-in-fact in respect to the exercise of any rights under the Notice and Agreement and agree to be bound by the
provisions of the Notice and Agreement insofar as I may have any rights in said Notice and Agreement, the Restricted Stock Units or any Shares issued pursuant thereto under the community property laws or similar laws relating to marital property in
effect in the state or country of our residence as of the date of the signing of the foregoing Notice and Agreement. 

					
			
	Dated:	 	 	 	, 20        
		 		 	

  

	
	   

	Signature of Spouse

 
			
		
	Print Name:        	 	 

  
 - 7 -EX-10.1

 Exhibit 10.1 

SETTLEMENT AGREEMENT 

This Settlement Agreement (this “Settlement Agreement”), dated as of 22 May, 2018, is by and among: 

Omeros Corporation, a corporation organized and existing under the laws of Washington (“Omeros”); and 

Lupin Ltd, a corporation organized and existing under the laws of India, and Lupin Pharmaceuticals, Inc., a Delaware corporation
(collectively, “Lupin”). Omeros and Lupin are each sometimes referred to herein individually as a “Party” and are referred to collectively as the “Parties.” 

WITNESSETH: 
 WHEREAS,
Omeros is the owner of the OMIDRIA Patents, as defined below; and 
 WHEREAS, Omeros is the holder of New Drug Application (“NDA”)
No. 205388, pursuant to which it markets and sells OMIDRIA®, a pharmaceutical product containing the active ingredients phenylephrine hydrochloride and ketorolac tromethamine, in and for
the United States; and 
 WHEREAS, Omeros and Lupin are involved in litigation in the United States District Court for the District of
Delaware, Civil Action No. 1:17-cv-00799-RGA (the “Action”), concerning, inter alia, the validity of the OMIDRIA
Patents (as defined below), as well as the alleged infringement by Lupin of the OMIDRIA Patents resulting from Lupin’s requesting approval from the United States Food and Drug Administration (the “FDA”) for the distribution and sale
of the ANDA Product (as defined below) prior to expiry of the OMIDRIA Patents pursuant to Abbreviated New Drug Application (“ANDA”) No. 210183; and 

 WHEREAS, in the Action, Omeros has asserted claims against Lupin; and 

WHEREAS, in the Action, Lupin has asserted counterclaims and defenses against Omeros challenging the validity or infringement of the OMIDRIA
Patents, and has sought a declaration of invalidity of the OMIDRIA Patents; and 
 WHEREAS, the Parties now seek to resolve the Action
without further litigation. 
 NOW, THEREFORE, for good and valuable consideration, the sufficiency and receipt of which are hereby
acknowledged, the Parties intending to be legally bound do hereby agree as follows: 
 ARTICLE 1: DEFINITIONS 

1.1.    The capitalized terms used in this Settlement Agreement shall have the meanings defined in this Article or
elsewhere in this Settlement Agreement. 
 1.2.    Unless the context requires otherwise, words referred to in the
singular include the plural and vice versa, the words “include,” “includes” and “including” will be deemed to be followed by the phrase “without limitation” (unless already present), the words
“herein,” “hereof” and “hereunder,” and words of similar import, will be construed to refer to this Settlement Agreement in its entirety and not to any particular provision hereof, and the word “or” is used in
the inclusive sense (and/or). 
 1.3.    The term “Action” shall have the meaning set forth in the preamble.

 1.4.    The term “Affiliate” shall mean, with respect to a Party, any entity or person that, directly or
indirectly through one or more intermediaries, controls, is controlled by, or is under common control with such Party. For purposes of this definition, “control” 

  
 2 

 
means (a) ownership, directly or through one or more intermediaries, of (i) more than fifty percent (50%) of the shares of stock entitled to vote for the election of directors, in the
case of a corporation, or (ii) more than fifty percent (50%) of the equity interests in the case of any other type of legal entity or status as a general partner in any partnership, or (b) any other arrangement whereby an entity or person
has the right to elect a majority of the board of directors or equivalent governing body of a corporation or other entity or the right to direct the management and policies of a corporation or other entity. 

1.5.    The term “Agencies” shall have the meaning set forth in Section 9.1. 

1.6.    The term “ANDA Product” shall mean a Generic OMIDRIA Product sold, offered for sale or distributed
pursuant to ANDA No. 210183, including supplements or amendments to ANDA No. 210183, but excluding any such supplements or amendments after the original filing date of ANDA No. 210183 that change the mode of administration or active
ingredient(s). 
 1.7.    The term “Approved OMIDRIA Product” shall mean any product sold, offered for sale or
distributed pursuant to NDA No. 205388, including any supplements or amendments to NDA No. 205388, but excluding any such supplements or amendments after the original filing date of NDA No. 205388 that change the mode of
administration or active ingredient(s). 
 1.8.    The term “Authorized Generic” shall mean a pharmaceutical
product that is manufactured, sold, offered for sale or distributed pursuant to NDA No. 205388 but is not sold under the trade name OMIDRIA® or another trade name or trademark owned by
Omeros or its Affiliates. 

  
 3 

 1.9.    The term “District Court” shall have the meaning set forth
in Section 2.1. 
 1.10.    The term “Effective Date” shall have the meaning set forth in
Section 2.3. 
 1.11.    The term “Entry Date” shall have the meaning set forth in Section 5.2. 

1.12.    The term “Fee Term” shall mean the period beginning on the date of expiration of the last-to-expire of the OMIDRIA Patents Family through the date of expiration of the period of Pediatric Exclusivity. 

1.13.    The term “First-Filer Exclusivity” shall mean the period of exclusivity pursuant to 21 U.S.C. §
355(j)(5)(B)(iv) with respect to the first-filed ANDA containing a Paragraph IV Certification for which the Approved OMIDRIA Product is the reference-listed drug. 

1.14.    The term “Generic OMIDRIA Product” shall mean a drug product that is sold, offered for sale or
distributed under an ANDA or application pursuant to 21 U.S.C. § 355(b)(2) that refers to the Approved OMIDRIA Product as the reference-listed drug or listed drug relied upon, as applicable. 

1.15.    The term “Losses” shall mean any claim, counterclaim, demand, cause of action, suit, damages, debt,
liability, obligation, right, or set-off of any and all kind or description whatsoever, including in relation to obtaining, enforcing, challenging or defending intellectual property or rights, including costs,
expenses, and attorneys’ fees related thereto or arising therefrom. 
 1.16.    The term “Lupin
Releasees” shall have the meaning set forth in Section 3.1. 

  
 4 

 1.17.    The term “Net Sales” shall mean, with respect to any
period, the actual gross amounts invoiced by Lupin and its Affiliates on all of its sales to Third Parties of the ANDA Product in or for the Territory (including, but not limited to, hospital sales, mail order sales, retail sales, and sales to
governmental entities, wholesalers, distributors, group purchasing organizations, long term care facilities, and medical institutions), subject to the following enumerated points: 

 

	 	a)	“Net Sales” shall be such gross amounts less the following deductions, all as determined consistent with the customary practices in the pharmaceutical industry in the Territory, consistently applied, and
which, as applicable, are actually incurred, allowed, accrued, or specifically allocated with respect to the ANDA Product, including only: 

  

	 	(1)	normal and customary cash discounts, quantity discounts, promotional discounts, stocking or other promotional allowances; 

  

	 	(2)	sales and excise taxes, customs and any other taxes imposed on the sale, importation, use or distribution of the ANDA Product, all to the extent added to the sale price and paid and not recovered or recoverable in
accordance with applicable law (but not including taxes assessed against the income derived from such sale); 

  

	 	(3)	returns, recalls and returned goods allowances; 

  

	 	(4)	retroactive corrections (including price adjustments, including those on customer inventories following price changes) and corrections for billing errors or shipping errors; 

 

	 	(5)	chargebacks, rebates, any other similar allowances, and the portion of administrative fees, in each case, actually granted, allowed or paid to any person or entity, including group purchasing organizations, managed
health care organizations and to governments, including their agencies, or to trade customers, in each case that are not Affiliates of Lupin, and that are directly attributable to the sale of the ANDA Product; and 

  
 5 

	 	(6)	redistribution center (RDC) fees, information service agreement (ISA) fees, and like fees that are customary in the industry that are passed from wholesalers, retailers, distributors, and other customers back to Lupin.

 For the sake of clarity, all such deductions represent reductions to the gross amount invoiced for sales of the ANDA
Product by Lupin or its Affiliates to Third Parties in the Territory in accordance with GAAP. Net Sales shall be determined from Lupin’s books and records kept in accordance with GAAP, as consistently applied, subject to quarterly true-ups based on actual deductions and credits. For clarity, the transfer of the ANDA Product by Lupin to one of its Affiliates shall not be considered a sale, it being understood that Net Sales by Affiliates shall
be determined based upon gross invoice price of such product sold by such Affiliate to independent Third Parties, less the deductions set forth in this paragraph above. If the ANDA Product is bundled with other products, any discounts or other
adjustments with respect to the applicable ANDA Product shall be allocated pro rata across all products in such bundle based on the non-discounted, non-adjusted price
for each such product. During the Payment Term, Lupin shall not, and shall cause its Affiliates not to, grant or provide any rebate, discount or allowance on or with respect to the ANDA Product that is designed or intended to encourage the purchase
by Third Parties of products other than the ANDA Product, other than any rebate, discount or allowance Lupin or any of its Affiliates offer on a general basis and not as a loss leader for the ANDA Product; provided that if the ANDA Product is sold
with other products on a portfolio basis, no rebate, discount or allowance on or with respect to the ANDA Product shall be greater on a percentage basis in any material respect than any rebate, discount or allowance on or with respect to any other
product in such portfolio. 
  

	 	b)	“Net Sales” with respect to sales of the ANDA Product that are not made on an arm’s length basis or that are made for consideration other than cash shall be calculated based on the average per unit Net
Sales of the ANDA Product, without regard to such non-cash sales. If sales of the ANDA Product are made for consideration that includes non-cash consideration as a
component, but not the entirety, of the total consideration, “Net Sales” will be adjusted to take account of the value of the non-cash consideration component. Sales not made on an arm’s length
basis will be calculated at average per unit Net Sales. 

  
 6 

 1.18.    The term “OMIDRIA Patents” shall mean United States Patent
Numbers 8,173,707; 8,586,633; 9,066,856; 9,278,101; 9,399,040; 9,486,406; and 9,855,246. 
 1.19.    The term
“OMIDRIA Patents Family” shall mean the OMIDRIA Patents and any United States patents issued from a patent application that is a divisional of, continuation of,
continuation-in-part of, or otherwise shares common priority with, an application from which one or more of the OMIDRIA Patents issued, or any amendment, reissue or
reexamination thereof. 
 1.20.    The term “Omeros Releasees” shall have the meaning set forth in
Section 3.2. 
 1.21.    The term “Par” shall mean Par Sterile Products, LLC and Par Pharmaceutical, Inc.

 1.22.    The term “Payment Term” shall mean the Royalty Term and the Fee Term. 

1.23.    The term “Pediatric Exclusivity” means any pediatric exclusivity rights conferred by Section 505A
of the Federal Food, Drug, and Cosmetic Act (as set forth at 21 U.S.C. ch. 9 §301 et seq.) with respect to the Approved OMIDRIA Product in the United States. 

1.24.    The term “Pre-Marketing” shall mean (a) communicating to
potential purchasers that Lupin or its Affiliates will be selling the ANDA Product in the Territory on or after the Entry Date (including, for example, notification to customers regarding the ANDA Product, and engaging customers in non-binding pricing/contracting activities), (b) importing the ANDA Product into the Territory before the Entry Date, (c) manufacturing the ANDA Product or having the ANDA Product manufactured before the Entry
Date, and (d) shipping 

  
 7 

 
or delivering or distributing the ANDA Product to Third Party distributors or Affiliated distributors before the Entry Date. For the avoidance of doubt, the limited
Pre-Marketing permitted pursuant to Section 5.4 shall not include entering into binding contracts before the Entry Date for the sale of the ANDA Product to a Third Party other than a distributor, making
binding offers before the Entry Date to sell the ANDA Product to a Third Party other than a distributor, or selling ANDA Product to a Third Party other than a distributor before the Entry Date. For the further avoidance of doubt, the limited Pre-Marketing permitted pursuant to Section 5.4 shall not include the disclosure of any non-public terms of this Settlement Agreement. 

1.25.    The term “Regulatory Exclusivity” means any exclusive marketing rights or data protection or other
exclusivity rights conferred by the FDA or statute with respect to the Approved OMIDRIA Product in the Territory, other than a patent right, including orphan drug exclusivity and Pediatric Exclusivity. 

1.26.    The term “Royalty Term” shall mean the period beginning on the Entry Date and ending on the date of
expiration of the last-to-expire of the OMIDRIA Patents Family. 

1.27.    The term “Signing Date” shall have the meaning set forth in Section 2.1. 

1.28.    The term “Territory” shall mean the United States of America and its territories and possessions,
including the Commonwealth of Puerto Rico and the District of Columbia. 
 1.29.    The term “Third Party”
shall mean any entity or person that is not a Party or an Affiliate of a Party. 

  
 8 

 1.30.    The term “Third Party
Pre-Marketing Date” shall have the meaning set forth in Section 5.6. 
 ARTICLE 2:
CONSENT JUDGMENT 
 2.1.    Within one (1) business day after the date of signature of the last Party to sign
this Settlement Agreement (the “Signing Date”), and earlier if possible, and subject to the confidentiality provisions of Section 10.1, counsel for the Parties shall execute a “Consent Judgment” providing for the terms of a
consent judgment and stipulated dismissal of the Action, in the form attached hereto as Exhibit A, and shall file it in the United States District Court for the District of Delaware (the “District Court”) in the Action. 

2.2.    If for any reason the District Court raises an objection to the Consent Judgment as drafted or requires that the
Parties modify the Consent Judgment before it will enter it as an order of the District Court, or if after ten (10) business days the District Court has otherwise failed to enter the Consent Judgment, the Parties agree to confer promptly and in
good faith in order to take action consistent with this Settlement Agreement to secure entry of the Consent Judgment as drafted, or to agree upon modifications to the Consent Judgment, or to take such other action consistent with this Settlement
Agreement to secure entry of the Consent Judgment as drafted or with agreed-upon modifications; provided, however, that nothing contained herein shall be deemed to require a Party to agree to a modification of the Settlement Agreement or Consent
Judgment that materially affects the benefits to be obtained by, or burdens imposed upon, such Party under this Settlement Agreement as originally executed. If, after forty-five (45) calendar days have elapsed from the date on which the Consent
Judgment was filed, such efforts have failed to secure entry of the Consent Judgment as originally filed or with agreed-upon modifications, notwithstanding anything herein to the contrary, this Settlement Agreement shall be null and void and have no
further legal effect, save for Sections 10.1, 10.4, 10.9, 10.12, and 10.14, which shall continue in full force and effect. 

  
 9 

 2.3.    The date on which the Consent Judgment is entered by the District
Court, whether with or without modification as provided for in Section 2.2, shall be the “Effective Date” of this Settlement Agreement. Notwithstanding anything herein to the contrary, the provisions of Articles 1, 2, 8, and 9 and
Sections 10.1, 10.3, 10.4, and 10.6 through 10.14 shall become effective upon the Signing Date. 
 ARTICLE 3: MUTUAL RELEASES 

3.1.    In settlement of the disputed claims in the Action, and in consideration of the representations, warranties and
covenants contained in this Settlement Agreement, subject to and effective only upon entry of the Consent Judgment (whether with or without modification as provided for in Section 2.2), Omeros, on behalf of itself and its Affiliates, and its
and their respective predecessors, successors, assigns, agents, officers, directors, employees and representatives, hereby fully, finally and irrevocably relinquishes, releases and discharges Lupin and its Affiliates, and its and their respective
predecessors, successors, assigns, agents, officers, directors, employees, representatives, suppliers, importers, manufacturers, distributors and customers (the “Lupin Releasees”), from any and all claims, demands, damages, liabilities,
obligations, and causes of action known or unknown, suspected or unsuspected, in law or equity, including costs, expenses and attorneys’ fees, that were asserted, or that could have been asserted, by Omeros or any of its Affiliates in
connection with the ANDA Product, the Approved OMIDRIA Product or the Action and arising before the Effective Date of this Settlement Agreement. For the avoidance of doubt, the release granted under this Section 3.1 shall not apply to any
finished product aside from the ANDA Product, or to the supply of ingredients for any finished product aside from the ANDA Product. 

  
 10 

 3.2.    In settlement of the disputed claims in the Action, and in
consideration of the representations, warranties and covenants contained in this Settlement Agreement, subject to and effective only upon entry of the Consent Judgment (whether with or without modification as provided for in Section 2.2),
Lupin, on behalf of itself and its Affiliates, and its and their respective predecessors, successors, assigns, agents, officers, directors, employees and representatives, hereby fully, finally and irrevocably relinquishes, releases and discharges
Omeros and its Affiliates, and its and their respective predecessors, successors, assigns, agents, officers, directors, employees, representatives, suppliers, importers, manufacturers, distributors and customers (the “Omeros Releasees”),
from any and all claims, demands, damages, liabilities, obligations, and causes of action known or unknown, suspected or unsuspected, in law or equity, including costs, expenses and attorneys’ fees, that were asserted, or that could have been
asserted, by Lupin or any of its Affiliates in connection with the ANDA Product, the Approved OMIDRIA Product or the Action and arising before the Effective Date of this Settlement Agreement. 

3.3.    In connection with this Settlement Agreement, the Parties and all of their respective Affiliates expressly waive
and relinquish all rights and benefits afforded by Section 1542 of the California Civil Code, which provides as follows: 
 A GENERAL
RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES NOT KNOW OR SUSPECT TO EXIST IN HIS OR HER FAVOR AT THE TIME OF EXECUTING THE RELEASE, WHICH IF KNOWN TO HIM OR HER MUST HAVE MATERIALLY AFFECTED HIS OR HER SETTLEMENT WITH THE DEBTOR. 

  
 11 

 Further, the Parties and all of their respective Affiliates expressly waive and relinquish all rights and
benefits afforded by any law in any other jurisdiction similar to Section 1542 of the California Civil Code. 

3.4.    For the avoidance of doubt, the releases set forth in this Article 3 do not apply to actions to enforce any
requirements or provisions of this Settlement Agreement, including, but not limited to, the provisions of the Consent Judgment. 
 ARTICLE
4: PATENT VALIDITY AND INFRINGEMENT 
 4.1.    Subject to Section 6.2(g), Lupin, for itself and its Affiliates,
acknowledges and agrees that the OMIDRIA Patents are valid and enforceable and would be infringed by the manufacture, use, sale, offer to sell, importation or distribution of the ANDA Product in or for the Territory prior to the Entry Date. 

4.2.    Lupin, for itself and its Affiliates, agrees not to challenge or otherwise dispute or contest, and not to assist
others, whether directly or indirectly, or join in any action, challenging or otherwise disputing or contesting, in any litigation or proceeding (a) the validity, enforceability, or patentability of any patent in the OMIDRIA Patents Family, or
(b) the infringement of any patent in the OMIDRIA Patents Family by the manufacture, use, sale, offer to sell, importation or distribution of a Generic OMIDRIA Product, in each case ((a) and (b)) in any court or administrative agency (including
without limitation the United States Patent and Trademark Office) having jurisdiction to consider the issue, except as may be required pursuant to compulsory legal process in litigation or other proceeding initiated by a Third Party without
assistance by Lupin or its Affiliates. Without limiting the generality of the foregoing, Lupin shall instruct the attorneys and experts engaged by or on behalf of Lupin in connection with the Action not to use or transfer to any Third Party any
confidential information of Omeros or its Affiliates or any work product or other materials generated in 

  
 12 

 
connection with the Action, unless such disclosure is compelled by law. Notwithstanding the foregoing, Lupin shall not be precluded from challenging in court the validity, enforceability or
infringement of any patent in the OMIDRIA Patents Family in an action that does not involve or have as its basis, cause, or predicate any or all of the following: (i) the ANDA Product, (ii) the Approved OMIDRIA Product, and (iii) a
Generic OMIDRIA Product. 
 4.3.    Lupin, on behalf of itself and its Affiliates, agrees not to seek, directly or
indirectly (including, for clarity, by or through its attorneys or agents or through or by assisting any Third Party, whether directly or indirectly), reexamination, inter partes review or any other post-grant review of the OMIDRIA Patents.
Notwithstanding the foregoing Sections 4.2 and 4.3, in the event that (a) Lupin has filed or files with FDA a certification under 21 U.S.C. § 355(j)(2)(A)(vii)(IV) as to a patent in the OMIDRIA Patent Family with respect to a Lupin product
other than the ANDA Product or any Generic OMIDRIA Product and (b) Omeros affirmatively asserts a patent claim of such patent against Lupin in a future action with respect to such Lupin product, Lupin shall not be precluded from challenging the
patentability of such claim at the U.S. Patent and Trademark Office. For clarity, Lupin shall not be permitted to challenge any patent claim that Omeros has not asserted in such future action as described in clause (b) in the preceding
sentence. 
 ARTICLE 5: LICENSE 

5.1.    Omeros, for itself and its Affiliates, hereby grants Lupin and its Affiliates, on and from the Entry Date through
the expiration of the last-to-expire of the OMIDRIA Patents Family, a royalty-bearing (in accordance with Section 7.1),
non-exclusive, non-sublicensable, non-transferable (except as expressly permitted by Section 10.3) right and license under
their respective rights in and to the OMIDRIA Patents Family to make, have made, use, sell, offer to sell, import, and distribute the ANDA Product in or for the Territory. 

  
 13 

 
For the avoidance of doubt, the right and license granted under this Section 5.1 shall not apply to the manufacture or distribution of the ANDA Product for sale to Third Parties for use or
consumption outside the Territory. For the further avoidance of doubt, the right and license granted under this Section 5.1 shall not apply to the manufacture or distribution of any finished product aside from the ANDA Product, or to the supply
of ingredients for any finished product aside from the ANDA Product. 
 5.2.    For the purposes of this Settlement
Agreement, the “Entry Date” shall mean the earliest of (a) (i) October 1, 2032 if Par is entitled to and has not forfeited First-Filer Exclusivity as of April 1, 2032, or (ii) April 1, 2032 if Par is not entitled
to First-Filer Exclusivity or if Par has forfeited First Filer Exclusivity as of such date, (b) the date of one or more final decision(s) of a U.S. court or the U.S. Patent Trial and Appeal Board from which no appeal has been or can be taken
(other than a petition to the U.S. Supreme Court for a writ of certiorari) holding that all claims of the OMIDRIA Patents asserted by Omeros and adjudicated at the time of such final decision(s) are invalid or unenforceable, (c) the date on
which all the OMIDRIA Patents have been permanently abandoned, expired, or delisted from the FDA’s Orange Book; provided that all periods of Regulatory Exclusivity have expired, (d) the date on which any Third Party generic manufacturer
(other than Par) launches a Generic OMIDRIA Product in the Territory under a license or other agreement with Omeros or any of its Affiliates, and (e) the date on which Omeros or any of its Affiliates or a Third Party launches an Authorized
Generic under a license or other agreement with Omeros or its Affiliates. 

  
 14 

 5.3.    Nothing in these grants to Lupin or its Affiliates or otherwise
contained in this Settlement Agreement shall give rise to an express or implied license under any patent other than the OMIDRIA Patents Family. 

5.4.    Notwithstanding any of the provisions of Articles 5 and 6, Lupin and its Affiliates may engage in (i) the Pre-Marketing activities contemplated under clauses (b), (c) and (d) of Section 1.24 from the date that is six (6) months in advance of the Entry Date and (ii) the
Pre-Marketing activities contemplated under clause (a) of Section 1.24 from the date that is thirty (30) days in advance of the Entry Date. Except as provided in the immediately preceding
sentence, Lupin and its Affiliates may not engage in any of the Pre-Marketing activities contemplated under Section 1.24 prior to the Entry Date. 

5.5.    Omeros, for itself and its Affiliates, hereby grants Lupin and its Affiliates, on and from the expiration of the last-to-expire of the OMIDRIA Patents Family through the expiration of any period of Pediatric Exclusivity, a fee-bearing (in
accordance with Section 7.2), non-exclusive, non-sublicensable, non-transferable (except as expressly permitted by
Section 10.3) selective waiver of Pediatric Exclusivity solely with respect to the making, having made, using, selling, offering to sell, importing, and distributing the ANDA Product in or for the Territory. 

5.6.    If Omeros or its Affiliates enters into or has entered into a written agreement, license, sublicense, settlement,
covenant, waiver or authorization of any kind with any Third Party, except for the Settlement Agreement entered into between Omeros and Par dated October 4, 2017, that grants the right to such Third Party to engage in any Pre-Marketing activities prior to the dates specified in Section 5.4 (the “Third Party Pre-Marketing Date”), then the date for the applicable Pre-Marketing activities specified in 

  
 15 

 
Section 5.4 shall automatically be adjusted to be the same as the applicable Third Party Pre-Marketing Date. Omeros shall provide Lupin with notice of
any such Third Party Pre-Marketing Date within ten (10) business days after the later of (a) the Effective Date and (b) the date of execution of any agreement granting the applicable Third Party
Pre-Marketing Date. If Omeros or its Affiliates enters into or has entered into a written agreement, license, sublicense, settlement, covenant, waiver or authorization of any kind with any Third Party, except
for the Settlement Agreement entered into between Omeros and Par dated October 4, 2017, that grants the right to such Third Party to sell an ANDA Product or an Authorized Generic earlier than the dates in Section 5.2 (a)(i) or 5.2(a)(ii)
of this Settlement Agreement, then Omeros shall provide Lupin with notice of any such agreement within ten (10) business days after the later of (a) the Effective Date and (b) the date of execution of any such agreement with a Third
Party, and this Settlement Agreement shall automatically be amended to grant Lupin such earlier entry date. Omeros shall give notice to Lupin at least two (2) months before Omeros or its Affiliates launches an Authorized Generic. 

ARTICLE 6: COVENANTS 

6.1.    Lupin, for itself and its Affiliates, hereby covenants as of the Effective Date of this Settlement Agreement and
thereafter during the time that this Settlement Agreement is in effect: 
  

	 	a)	Not to sue, not to assign to any other entity a right to sue, and not to authorize any other entity to sue, any Omeros Releasee for Losses, known or unknown, suspected or unsuspected, in law or equity, that were
asserted or that could have been asserted by Lupin in connection with ANDA No. 210183, the ANDA Product, an Approved OMIDRIA Product or the Action and arising before the Effective Date of this Settlement Agreement; and 

 

	 	b)	 Unless otherwise permitted under this Settlement Agreement, that neither Lupin nor its Affiliates will, directly
or indirectly, (i) at any time beginning with the Effective Date of this Settlement 

  
 16 

	 	
Agreement and ending at 12:01 a.m. on the Entry Date, (A) use, sell, offer to sell, import or distribute in or into the Territory or (B) make or have made in the Territory or
(ii) at any time beginning with the Effective Date of this Settlement Agreement and ending at 12:01 a.m. on the Entry Date, authorize, assist or materially encourage others to (A) use, sell, offer to sell, import or distribute in or into
the Territory or (B) make or have made in the Territory or indemnify others regarding or participate in the profits of others arising from, or otherwise receive consideration with respect to, the sale in or into the Territory of, in the case of
both clauses (i) and (ii), the ANDA Product or any other Generic OMIDRIA Product; and 

  

	 	c)	Unless otherwise permitted under this Settlement Agreement, not to sue, not to assign to any other entity a right to sue, and not to authorize, assist or materially encourage any other entity to sue, any Omeros Releasee
for any claim, counterclaim, demand, cause of action, suit, damages, debt, liability, obligation, right, or set-off of any and all kind or description whatsoever arising out of the sale of the ANDA Product in
or into the Territory; and 

  

	 	d)	Not to encourage, induce or otherwise facilitate any Third Party to take any action that would be a breach of this Settlement Agreement if engaged in by Lupin or its Affiliates (including, for clarity, seeking
reexamination, inter partes review or any other post-grant review of any patent in the OMIDRIA Patents Family, other than as expressly permitted by Section 4.3). 

6.2.    Omeros, for itself and its Affiliates, hereby covenants as of the Effective Date of this Settlement Agreement and
thereafter during the time that this Settlement Agreement is in effect: 
  

	 	a)	Not to sue, not to assign to any other entity a right to sue, and not to authorize, assist or materially encourage any other entity to sue, any Lupin Releasee or their suppliers, distributors, or customers (including
doctors and patients) for Losses, known or unknown, suspected or unsuspected, in law or equity, that were asserted or that could have been asserted by Omeros in connection with ANDA No. 210183, the ANDA Product, an Approved OMIDRIA Product or
the Action and arising before the Effective Date of this Settlement Agreement; and 

  

	 	b)	 Not to assert any patent remedies to which they would be entitled under 35 U.S.C. § 271(e)(4) or any other
U.S. patent law (i) if the District Court had found that Lupin’s filing of ANDA No. 210183 infringed the OMIDRIA Patents or any United States patents or 

  
 17 

	 	
patent applications owned, in-licensed or otherwise controlled by, now or in the future, Omeros or any of their Affiliates or (ii) with respect to the
sale of the ANDA Product on or after the Entry Date; and 

  

	 	c)	Unless required by the FDA or for purposes of public policy or safety, not to (i) delete, remove or cancel, or cause or permit the deletion, cancellation or removal of NDA No. 205388, any National Drug Code(s)
or any other relevant codes for the Approved OMIDRIA Product from the National Drug File maintained by First Databank for the Territory or from any other pricing database in the Territory, in each case, in a manner that would prevent substitution of
the ANDA Product, (ii) take any action to or authorize, assist or materially encourage any other entity to take any action to, prevent or delay the approval, launch, manufacture, use, sale, offer for sale, importation or distribution of the
ANDA Product in or for the Territory as permitted under the terms of this Settlement Agreement. For the avoidance of doubt, the foregoing shall not prohibit Omeros or any of its Affiliates from taking any action, directly or indirectly, to promote
or encourage the sale of the Approved OMIDRIA Product; and 

  

	 	d)	Within seven (7) business days of Lupin’s written request, to provide the FDA with written confirmation of the Entry Date and the licenses, covenants and waivers herein; and 

 

	 	e)	From and after the date that is six (6) months in advance of the Entry Date, not to sue, not to assign to any other entity a right to sue, and not to authorize, assist or materially encourage any other entity to
sue, any Lupin Releasee or any of their manufacturers for any Losses asserting that the manufacture of the ANDA Product in a country solely for distribution in the Territory infringes any patents or patent applications filed or maintained in such
country that are owned, in-licensed or otherwise controlled by, now or in the future, Omeros or any of their Affiliates; and 

 

	 	f)	 (i) Not to sue, not to assign to any other entity a right to sue, and not to authorize, assist or materially
encourage any other entity to sue, any Lupin Releasee or any of their manufacturers, suppliers, distributors, or customers (including doctors and patients) for any Losses asserting that the manufacture, use, sale, offer for sale, importation or
distribution of the ANDA Product in or for the Territory, during the period that the license grant in Section 5.1 is in effect (or, with respect to Pre-Marketing activities, during the applicable period
set forth in Section 5.4), infringes any United States patents or patent applications owned, in-licensed or otherwise controlled by, now or in the future, Omeros or any of their Affiliates

  
 18 

	 	
and (ii) to impose the foregoing covenant not to sue on any Third Party to which it or any of its Affiliates may assign or otherwise transfer, or license or sublicense, any such patent
rights. For the avoidance of doubt, the immediately foregoing covenant not to sue shall not apply to the manufacture or distribution of the ANDA Product for sale to Third Parties for use or consumption outside the Territory; and 

 

	 	g)	Not to assert any argument or position or in any way knowingly suggest to a Third Party, court or administrative agency that Lupin is bound by, or otherwise seek any remedy with respect to, the provisions of
Section 4.1 in any litigation, action, or other proceeding with respect to an ANDA or an application pursuant to 21 U.S.C. § 355(b)(2) (or a product made, sold or distributed pursuant to such ANDA or such application) in which the Approved
OMIDRIA Product is not the reference-listed drug or the listed drug relied upon, as applicable. 

 ARTICLE 7: ROYALTIES;
WAIVER FEE; RECORD-KEEPING; AUDIT 
 7.1.    In consideration of the license granted under Article 5, Lupin shall
pay to Omeros running royalties in an amount equal to fifteen percent (15%) of Net Sales of the ANDA Product during the Royalty Term; provided that (a) Lupin shall not pay any royalties if the Entry Date is triggered by clause (a)(i) of
Section 5.2 and (b) Lupin shall not pay any royalties from and after the date upon which an Authorized Generic product or a Generic OMIDRIA Product other than the ANDA Product is distributed, sold or offered for sale in the United States.
Lupin shall pay such royalties in accordance with this Article 7. 
 7.2.    In consideration of the selective waiver of
Pediatric Exclusivity granted under Article 5, Lupin shall pay to Omeros a waiver fee in an amount equal to fifteen percent (15%) of Net Sales of the ANDA Product during the Fee Term; provided that (a) Lupin shall not pay any waiver fee
if the Entry Date is triggered by clause (a)(i) of Section 5.2 and (b) Lupin shall not pay any waiver fee from and after the date upon which an Authorized Generic product or a Generic OMIDRIA Product other than the ANDA Product is
distributed, sold or offered for sale in the United States. Lupin shall pay such waiver fee in accordance with this Article 7. 

  
 19 

 7.3.    Not later than sixty (60) days after the end of each calendar
quarter, commencing on the Entry Date and continuing through the end of the Payment Term, Lupin shall: 
  

	 	a)	Deliver to Omeros a written report, in such form as the Parties mutually agree, that contains the information specified in Exhibit B with respect to the prior calendar quarter; and 

 

	 	b)	Pay to Omeros, by wire transfer to an account designated in writing by Omeros, the amount owed to Omeros with respect to such calendar quarter as determined in accordance with Section 7.1 or Section 7.2, as
applicable. 

 7.4.    Lupin shall maintain, and shall cause its Affiliates to maintain, complete and
accurate books and records in such detail as is necessary to accurately calculate the amounts payable to Omeros under Section 7.1 and Section 7.2. Such books and records shall be maintained for a period of at least twelve (12) months
after the end of the Payment Term. Once during each calendar year of the Payment Term and on no less than thirty (30) days’ written notice to Lupin, Omeros shall have the right to have an independent accounting firm reasonably acceptable
to Lupin audit and examine the relevant books and records as may be reasonably necessary to determine or verify the amount of payments due hereunder and Lupin’s compliance with its obligations hereunder. Such audit and examination shall be
conducted and shall take place, and Lupin shall, and shall cause its Affiliates to, make such books and records available, during normal business hours at a facility in the United States. The audit shall be conducted expeditiously and within the
time reasonably necessary to accomplish the purposes of the audit. Before permitting such independent accounting firm to have access to such books and records, Lupin may require such independent accounting firm

  
 20 

 
and its personnel involved in such audit to sign a customary confidentiality agreement in form and substance reasonably acceptable to Lupin as to any information subject to confidential treatment
under Section 10.1 which is to be provided to such accounting firm or to which such accounting firm will have access while conducting the audit under this Section 7.4. The independent accounting firm will prepare and provide to the Parties
a written report stating whether the reports submitted and amounts paid pursuant to this Article 7 were correct or incorrect, and the amounts of any discrepancies. In the event that there was an underpayment or overpayment by Lupin hereunder, Lupin
or Omeros, as the case may be, shall promptly (but in no event later than thirty (30) days after receipt of the independent accountant’s report so concluding) make payment to the other of the amount of such underpayment or overpayment.
Omeros shall bear the costs and expenses of such audit, unless the audit finds a discrepancy of fifteen percent (15%) or more between Lupin’s payment obligations and payments for any audited period, in which case Lupin shall bear the cost of
such audit. 
 7.5.    Omeros shall be responsible for and shall pay all taxes payable on any income or any payments by
Lupin to Omeros. Lupin and Omeros shall bear sole responsibility for payment of compensation to their respective personnel, employees, or subcontractors and for all employment taxes and withholding with respect to such compensation pursuant to
applicable law. All payments made by Lupin to Omeros under this Settlement Agreement shall be made without any deduction or withholding for, or on account of, any tax, except that Lupin shall have the right to withhold taxes on income or income
equivalents in the event that the revenue authorities in any country require the withholding of taxes on amounts paid hereunder to Omeros. Lupin shall secure and promptly send to Omeros proof of such taxes, duties, or other levies withheld and paid
by Lupin for the benefit of Omeros. Each Party agrees to cooperate with the other Party in claiming exemptions from such deductions or withholdings under any agreement or treaty from time to time in effect. 

  
 21 

 7.6.    All amounts payable by Lupin hereunder shall be paid in U.S. dollars.

 7.7.    Any payment under this Settlement Agreement that is not made within sixty (60) days of when due shall
bear interest on such past due amount from the date such amount became past due until the date payment is actually made at a rate equal to “Prime” as defined in the print edition of The Wall Street Journal, Eastern Edition, on the payment
due date or, if unavailable, on the latest date prior to the payment due date on which such rate is available, calculated on a daily basis on the actual number of days elapsed from the payment due date to the date of actual payment. 

ARTICLE 8: REPRESENTATIONS AND WARRANTIES 

8.1.    Each Party represents and warrants to the other Party that: 

 

	 	a)	It has the corporate, partnership or limited liability company power and authority to enter into this Settlement Agreement and to perform its obligations hereunder; and 

 

	 	b)	The execution, delivery and performance of this Settlement Agreement have been duly authorized by all necessary corporate or other organizational actions of the Party and its Affiliates; and 

 

	 	c)	The execution and delivery of this Settlement Agreement and the performance by the Party of any of its obligations hereunder do not and will not conflict with or result in a breach of any other agreement to which it or
any of its Affiliates is a party, any judgment of any court or governmental body applicable to the Party or its properties, or, to the Party’s knowledge, any statute, decree, order, rule or regulation of any court or governmental authority
applicable to the Party or its properties; and 

  

	 	d)	Upon execution and delivery of this Settlement Agreement by both Parties, this Settlement Agreement is a valid obligation binding upon such Party and enforceable in accordance with its terms except as enforceability may
be limited in future bankruptcy or insolvency. 

  
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 8.2.    Lupin, on behalf of itself and its Affiliates, represents and
warrants to Omeros that, as of the Signing Date and the Effective Date of this Settlement Agreement, Lupin and its Affiliates own all right, title and interest in and to ANDA No. 210183, no other person or entity has any rights under ANDA
No. 210183, and neither Lupin nor any of its Affiliates has transferred or assigned any of their rights under ANDA No. 210183 to any party. 

8.3.    Lupin further represents and warrants to Omeros that, as of the Signing Date and the Effective Date of this
Settlement Agreement, neither Lupin nor its Affiliates have discussed with any Third Party any aspect of the negotiations of this Settlement Agreement or the Consent Judgment or any of the terms or conditions hereof or thereof. 

8.4.    No Party makes any express or implied warranties that any product or process can be made, used, sold, offered for
sale, imported or distributed without infringing intellectual property rights owned or controlled by Third Parties. 

8.5.    Omeros, on behalf of itself and its Affiliates, further represents and warrants to Lupin that they collectively or
individually or through one or more Affiliates own all right, title and interest in and to the OMIDRIA Patents, and neither they nor their Affiliates have transferred or assigned any of their rights under the OMIDRIA Patents to any Third Party. 

ARTICLE 9: NOTIFICATION OF SETTLEMENT AGREEMENT 

TO THE FEDERAL TRADE COMMISSION AND DEPARTMENT OF JUSTICE 

9.1.    Within ten (10) business days following the Signing Date, the Parties shall comply with the requirements of
Title XI, Subtitle B of the Medicare Prescription Drug, Improvement, and Modernization Act of 2003, Pub. L. No. 108-173, by filing or causing to be filed all necessary documents with the U.S. Federal
Trade Commission and the Antitrust Division of the U.S. Department of Justice (collectively the “Agencies”). 

  
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 9.2.    The Parties shall use commercially reasonable efforts to coordinate
the foregoing filings and any responses thereto, to make such filings promptly and to respond promptly to any requests for additional information made by either of the Agencies, and to coordinate any necessary or desirable joint presentations. Each
Party reserves the right to communicate with the Agencies regarding such filings as it believes appropriate. Each Party shall keep the other informed of such communications (unless otherwise directed by either of the Agencies) and shall not disclose
any confidential information of the other Party without that Party’s consent, which shall not be unreasonably withheld. 
 ARTICLE
10: GENERAL PROVISIONS 
 10.1.    Confidentiality. Either Party may issue a press release in the form agreed
to by the Parties and attached hereto as Exhibit C with respect to this Settlement Agreement. Except as expressly provided in the immediately preceding sentence or as required by statute, ordinance, regulation, or compulsory legal process, neither
the Parties nor their Affiliates shall publicly announce or otherwise disclose to Third Parties any of the confidential terms of this Settlement Agreement without the prior written approval of the other Party. Each Party acknowledges that, if the
stock of the other Party is publicly traded, the other publicly traded Party will be required to publicly disclose certain terms of this Settlement Agreement in filings with the United States Securities and Exchange Commission (“SEC”) and
will be required to include a copy of this Settlement Agreement in filings with the SEC, and, to the extent that the other publicly traded Party determines that such disclosures are required, notwithstanding the provisions of this Section 10.1,
each Party consents to the other publicly traded Party’s disclosure of such terms of this Settlement 

  
 24 

 
Agreement in SEC filings and the inclusion of a copy of this Settlement Agreement in filings with the SEC, with the timing, form and content of each as determined by the other publicly traded
Party in its sole discretion. Notwithstanding anything to the contrary above, (i) Omeros may disclose the terms of this Settlement Agreement to Third Parties in connection with patent litigation involving the Approved OMIDRIA Product or in
connection with settlement discussions and agreements related to or involving the Approved OMIDRIA Product, subject to such Third Parties undertaking to keep the terms of this Settlement Agreement strictly confidential in accordance with
confidentiality terms at least as restrictive as the terms hereof, and (ii) Lupin may disclose such terms of this Settlement Agreement to the FDA as may be necessary in obtaining and maintaining FDA approval of its ANDA No. 210183, so long
as Lupin requests that the FDA maintain such terms in confidence, and (iii) each Party may disclose the terms of this Settlement Agreement to its respective Affiliates, and its and their respective insurers, lenders, shareholders and
prospective investors, attorneys, accountants, and prospective and actual acquirers, subject to such Affiliates, insurers, lenders, shareholders and prospective investors, attorneys, accountants and prospective and actual acquirers undertaking to
keep the terms of this Settlement Agreement strictly confidential in accordance with confidentiality terms at least as restrictive as the terms hereof. 

10.2.    Indemnification. Lupin and its Affiliates shall indemnify, defend, and hold harmless Omeros and its
Affiliates from any claims, losses, liabilities, costs and expenses arising solely out of any breach of this Settlement Agreement by Lupin or its Affiliates. For clarity, the foregoing shall not limit any other rights to indemnification to which
Omeros is otherwise entitled. 

  
 25 

 10.3.    Assignment. This Settlement Agreement, including the
obligations of the Parties under the Consent Judgment, shall be binding upon and shall inure to the benefit of each Party hereto, and each of its Affiliates, successors and permitted assigns, and any Third Party to which any rights are transferred
under ANDA No. 210183 or the ANDA Product. Except as otherwise provided herein, none of Omeros and Lupin shall have the power to assign or otherwise transfer this Settlement Agreement or any interest herein or right hereunder without the prior
written consent of the other Party, such consent not to be unreasonably withheld, and any such purported assignment, transfer or attempt to assign or transfer any interest herein or right hereunder without such consent shall be void and of no
effect. Notwithstanding the foregoing, either Party may, upon written notice to the other Party but without obtaining the other Party’s consent, assign its rights and obligations under this Settlement Agreement to any of its Affiliates, to any
lender providing financing to that Party or its Affiliates for collateral security purposes, or to any successor in interest to that Party’s entire business or to its Approved OMIDRIA Product or Generic OMIDRIA Product business, as the case may
be, provided that (a) notwithstanding any such assignment, such Party shall remain liable for its and its Affiliates’ performance under this Settlement Agreement; (b) no such assignment shall in any manner limit or impair the
obligations of that Party hereunder; (c) no such assignment shall in any manner limit or impair the benefits provided to Omeros under Section 3.2, Section 4.2, Section 4.3 or Section 6.1 or provided to Lupin under
Section 3.1 or Section 6.2; and (d) following a transfer by a Party to its Affiliate, any subsequent transaction that would cause such Affiliate to cease to be an Affiliate of such Party shall be deemed to be an assignment of this
Settlement Agreement subject to this Section 10.3. 

  
 26 

 10.4.    Governing Law. This Settlement Agreement and the rights and
obligations of the Parties under this Settlement Agreement shall be governed and construed in accordance with the laws of the State of Delaware, without regard to its
choice-of-law or conflicts-of-law principles that might otherwise refer construction or
interpretation of this Settlement Agreement to the substantive law of another jurisdiction. The Parties hereby irrevocably and unconditionally consent to the exclusive jurisdiction of the courts of Delaware for any action, suit or proceeding
(other than appeals therefrom) arising out of or relating to this Settlement Agreement and agree not to commence any action, suit or proceeding (other than appeals therefrom) related thereto except in such courts. 

10.5.    Relief in the Event of Breach. Lupin, for itself and its Affiliates, acknowledges and agrees that the
restrictions set forth herein on the manufacture, use, sale, offer to sell, importation and distribution of the ANDA Product are reasonable and necessary to protect the legitimate interests of Omeros, that Omeros would not have entered into this
Settlement Agreement in the absence of such restrictions, and that any breach of those restrictions will result in irreparable injury to Omeros for which there will be no adequate remedy at law. Accordingly, if Lupin engages in a breach of any of
its undertakings in Section 4.2, Section 4.3 or Section 6.1 of this Settlement Agreement, in addition to any other remedy Omeros may have at law or in equity, Lupin agrees, that, upon a determination by a court of such breach, Omeros
shall be entitled to seek a preliminary injunction to prevent the continuance of such breach. Further, in the event that Lupin is finally determined by a court to have engaged in a breach of its undertakings in Section 4.2, Section 4.3 or
Section 6.1 of this Settlement Agreement, Omeros reserves, and Lupin and its Affiliates shall not contest, Omeros’s right to seek damages and any other remedies for patent infringement to the full extent of the law (although Lupin may
contest the quantum of damages or scope of other remedies). 

  
 27 

 10.6.    Waiver. No waiver of a breach, failure of any condition, or
any right or remedy, contained in or granted by the provisions of this Settlement Agreement shall be effective unless it is in writing and signed by the Party waiving the breach, failure, right or remedy. No waiver of any breach, failure, right or
remedy shall be deemed a waiver of any other breach, failure, right or remedy, whether or not similar, nor shall any waiver constitute a continuing waiver unless the writing so specifies. 

10.7.    Legal Advice. Each Party and its counsel have participated fully in the review and revision of this
Settlement Agreement. Any rule of construction to the effect that ambiguities are to be resolved against the drafting Party shall not apply in interpreting this Settlement Agreement. 

10.8.    Enforceability. If a court of competent jurisdiction holds any provision of this Settlement Agreement to
be illegal, unenforceable, or invalid, in whole or in part for any reason, the Parties agree to use commercially reasonable efforts to negotiate a provision, in replacement of the provision held illegal, unenforceable, or invalid, that is consistent
with applicable law and accomplishes, as nearly as possible, the original intention of the Parties with respect thereto. 

10.9.    Admissibility. In the event that there is no Effective Date of this Settlement Agreement or the Consent
Judgment is vacated, (a) neither the provisions of this Settlement Agreement, nor the Settlement Agreement itself (except the provisions hereof that remain in effect), may be offered into evidence, or be referred to in any testimonial or other
evidence, by any Party or any of their Affiliates at any trial, action or other proceeding 

  
 28 

 
pertaining to the subject matter hereof, and (b) nothing herein shall be construed as an admission or waiver by any Party or any of their Affiliates as to any factual or legal matter;
provided, however, that this Section 10.9 shall not apply in any actions to enforce any requirements or provisions of this Settlement Agreement or the Consent Judgment. 

10.10.    Entire Agreement. This Settlement Agreement and the Exhibits represent the entire understanding and
agreement of the Parties with regard to the matters addressed herein. 
 10.11.    Modification. No terms or
conditions of this Settlement Agreement will be varied or modified by any prior or subsequent statement, conduct or act of either Party, except that the Parties may supplement, amend, or modify this Settlement Agreement by a subsequent written
agreement executed by the Parties through their authorized representatives. 
 10.12.    Counterparts. This
Settlement Agreement may be executed in any number of counterparts, and through pdf, facsimile or photocopy signatures. Each counterpart shall be deemed an original instrument, but all counterparts together shall constitute but one agreement. 

10.13.    Limitation of Rights Granted. Except for the rights, agreements and covenants specifically granted
pursuant to this Settlement Agreement, no other rights, agreements or covenants are granted or implied by this Settlement Agreement. Lupin shall have no right, title or interest in or to (a) any trademark, trade dress, brand mark, service mark,
trade name, brand name, logo or other similar business symbol of Omeros or its Affiliates, including the trademark OMIDRIA® or any trade dress of any OMIDRIA® product or (b) any know-how, trade secrets, copyrights or other intellectual property of Omeros or its Affiliates, except the limited rights expressly
provided for herein. 

  
 29 

 10.14.    Notices:    All notices, requests,
demands, or other communications under this Settlement Agreement shall be in writing. Notice shall be sufficiently given (and shall be deemed to be duly given upon receipt) by delivery in person, by facsimile or by overnight delivery service
maintaining records of receipt to the respective Parties at the addresses specified below, or in each case such other address as such Party may hereafter specify by notice to the other Party. 

Addresses for purpose of giving notice are as follows: 

If to Omeros: 
 Omeros
Corporation 
 201 Elliott Avenue West 

Seattle, WA 98119 
 Fax No.:
206.676.5005 
 Attn.: Chief Executive Officer 

With a copy to: 
 Omeros
Corporation 
 201 Elliott Avenue West 

Seattle, WA 98119 
 Fax No.:
206.676.5005 
 Attn.: General Counsel 

If to Lupin: 
 Lupin Ltd. 

Attention: Managing Director 

Kalpataru Inspire, 3rd Floor 

Off Western Express Highway 

Santacruz (East), Mumbai 

400055 
 India 

Fax No.: +91 22 6640 2051 

  
 30 

 With a copy to: 

Knobbe, Martens, Olson & Bear, LLP 

1717 Pennsylvania Ave., N.W., Suite 900 

Washington, D.C. 20006 
 Fax
No.: (202) 640-6401 
 Attention: William R. Zimmerman 

Lupin Pharmaceuticals, Inc. 

Attention: Vice President Intellectual Property 

111 South Calvert Street 

Harborplace Tower 21st Floor 

Baltimore, MD 21202 
 Fax No.:
(410) 576-2221 
 [Signature Page Follows] 

  
 31 

 IN WITNESS WHEREOF, the Parties, through their authorized officers, have executed this Settlement
Agreement as of the Signing Date.      
  

									
	Omeros Corporation	 		 	Lupin Ltd
					
	By:	 	 /s/ Gregory A. Demopulos
	 		 	By:	 	 /s/ Nilesh Gupta

	Name:	 	Gregory A. Demopulos	 		 	Name:	 	Nilesh Gupta
	Title:	 	Chairman and CEO	 		 	Title:	 	Managing Director
	Date: May 22, 2018	 		 	Date: May 22, 2018
				
		 		 		 	Lupin Pharmaceuticals, Inc.
					
		 		 		 	By:	 	 /s/ Sean Moriarty

		 		 		 	Name:	 	Sean Moriarty
		 		 		 	Title:	 	Secretary
		 		 		 	Date: 21 May 2018

 EXHIBIT A: CONSENT JUDGMENT 

IN THE UNITED STATES DISTRICT COURT 

FOR THE DISTRICT OF DELAWARE 
  

					
	-------------------------------------------------------------------------------------------X	  	
	OMEROS CORPORATION,	  	:	  	
		  	:	  	
	 Plaintiff,
	  	:	  	
		  	:	  	
	 v.
	  	:	  	Civil Action No. 1:17-cv-00799-RGA
		  	:	  	
	LUPIN LTD, and	  	:	  	Hon. Richard G. Andrews, U.S.D.J.
	LUPIN PHARMACEUTICALS, INC.,	  	:	  	
		  	:	  	
	 Defendants.
	  	:	  	
	-------------------------------------------------------------------------------------------X	  	

 CONSENT JUDGMENT 

Plaintiffs Omeros Corporation (hereinafter “Omeros”), and Defendants Lupin Ltd and Lupin Pharmaceuticals, Inc. (hereinafter
collectively “Lupin”), the parties in the above-captioned action, have agreed to terms and conditions representing a negotiated settlement of this action and have set forth those terms and conditions in a Settlement Agreement (the
“Settlement Agreement”). Now the parties, by their respective undersigned attorneys, hereby stipulate and consent to entry of judgment and an injunction in this action as follows: 

IT IS this      day of             , 2018: 

ORDERED, ADJUDGED AND DECREED as follows: 

1.    This District Court has jurisdiction over the subject matter of the above action and has personal jurisdiction over
the parties. 
 2.     As used in this Consent Judgment, (i) the term “ANDA Product” shall mean a drug
product sold, offered for sale or distributed pursuant to Abbreviated New Drug Application No. 210183 (and defined in greater detail in the Settlement Agreement); the term “OMIDRIA Patents” shall mean United States Patent Numbers
8,173,707, 8,586,633, 9,066,856, 

 
9,278,101, 9,399,040, 9,486,406, and 9,855,246 and (iii) the term “Affiliate” shall mean any entity or person that, directly or indirectly through one or more intermediaries,
controls, is controlled by, or is under common control with Lupin; for purposes of this definition, “control” means (a) ownership, directly or through one or more intermediaries, of (1) more than fifty percent (50%) of the shares
of stock entitled to vote for the election of directors, in the case of a corporation, or (2) more than fifty percent (50%) of the equity interests in the case of any other type of legal entity or status as a general partner in any partnership,
or (b) any other arrangement whereby an entity or person has the right to elect a majority of the Board of Directors or equivalent governing body of a corporation or other entity or the right to direct the management and policies of a
corporation or other entity. 
 3.    Unless otherwise specifically authorized pursuant to the Settlement Agreement,
Lupin, including any of its Affiliates, successors and assigns, is enjoined until the Entry Date (as defined in the Settlement Agreement), from infringing the OMIDRIA Patents, on its own part or through any Affiliate, by making, having made, using,
selling, offering to sell, importing or distributing of the ANDA Product. 
 4.    Compliance with this Consent Judgment
may be enforced by Omeros and its successors in interest, or assigns, as permitted by the terms of the Settlement Agreement. 

5.    This District Court retains jurisdiction to enforce or supervise performance under this Consent Judgment and the
Settlement Agreement. 
 6.    All claims, counterclaims, affirmative defenses and demands in this action are hereby
dismissed with prejudice and without costs, disbursements or attorneys’ fees to any party. 
  

	
	  

	Richard G. Andrews, U.S.D.J.

 We hereby consent to the form and entry of this Order: 

Dated:            , 2018 

 

					
	  
 Jack B. Blumenfeld

Maryellen Noreika
 MORRIS, NICHOLS, ARSHT

& TUNNELL LLP
 1201 North Market Street

P.O. Box 1347
 Wilmington, DE 19899

(302) 658-9200
  

George Pappas
 Jeffrey Lerner

Gary Rubman
 Eric R. Sonnenschein

Meghan Monaghan
 COVINGTON & BURLING LLP

One CityCenter
 850 10th St NW

Washington, DC 20001
 (202)
662-6000
  
 Attorneys for Omeros
Corporation
	 		  	  
 Francis J. Murphy , Jr.

Jonathan L. Parshall
 MURPHY, SPADARO & LANDON

1011 Centre Road
 Suite 210

Wilmington, DE 19805
 (302)
472-8100
  
 Carol M. Pitzel Cruz

Jonathan E. Bachand
 William R. Zimmerman

KNOBBE MARTENS
 1717 Pennsylvania Avenue N.W., Suite 900

Washington, DC 20006
 (202)
640-6400
  
 Attorneys for Lupin Ltd and
Lupin Pharmaceuticals, Inc.

 EXHIBIT B 

REPORTING AND PAYMENT INFORMATION 
  

	1.	Gross Sales (units and dollars) 

  

	2.	Product Returns (dollars) 

  

	3.	Excise taxes, value added taxes, and duties (dollars) 

  

	4.	Trade, quantity, prompt pay and cash discounts (dollars) 

  

	5.	Allowances and credits (dollars) 

  

	6.	Rebates and chargebacks (dollars) 

 EXHIBIT C 

FORM OF PRESS RELEASE 
  

 
 Omeros Announces Settlement of Infringement Suit Against ANDA Filer Lupin 

—Lupin Confirms Validity of OMIDRIA Patents— 

SEATTLE, WA – May     , 2018 – Omeros Corporation (Nasdaq: OMER) today announced that it has entered into a settlement
agreement with Lupin Ltd. and its subsidiary Lupin Pharmaceuticals, Inc. (Lupin), resolving Omeros’ patent litigation against Lupin. The litigation concerned Lupin’s filing of an Abbreviated New Drug Application (ANDA) seeking approval
from the U.S. Food and Drug Administration (FDA) to market a generic version of Omeros’ commercial drug OMIDRIA® (phenylephrine and ketorolac intraocular solution) 1% / 0.3%. 

Last year, Omeros announced that it had settled litigation directed to an ANDA filing by Par Sterile Products, LLC and Par Pharmaceutical, Inc. (Par). As in
the settlement with Par, this agreement with Lupin includes Lupin’s acknowledgment and confirmation of the validity of all asserted patents for OMIDRIA as well as overall terms and market entry date similar to those set forth in the Par
agreement. The expiration date of the last-to-expire of Omeros’ asserted patents for OMIDRIA is October 23, 2033. 

The litigation against Lupin began in 2017 after Omeros received a Paragraph IV certification from Lupin in connection with Lupin’s filing of an ANDA
seeking the FDA’s approval to market a generic version of OMIDRIA. As part of the agreement, Lupin acknowledges and confirms the validity of each of the patents listed in the Orange Book for OMIDRIA, namely U.S. Patent No. 8,173,707, U.S.
Patent No. 8,586,633, U.S. Patent No. 9,066,856, U.S. Patent No. 9,278,101, U.S. Patent No. 9,399,040, U.S. Patent No. 9,486,406, and U.S. Patent No. 9,855,246. 

“We are pleased with the Lupin settlement agreement,” stated Gregory A. Demopulos M.D., chairman and chief executive officer of Omeros. “With
both the Par and Lupin litigation now settled, we remain focused on the near-term objectives for OMIDRIA – preparing for resumption of CMS separate payment on October 1, growing our customer base and expanding the drug’s Medicare
Advantage and commercial reimbursement – all of which we expect will increase access to OMIDRIA for ophthalmic surgeons and their cataract surgery patients, improving outcomes and decreasing safety risks. 

 About Omeros Corporation 

Omeros is a commercial-stage biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for
large-market as well as orphan indications targeting inflammation, complement-mediated diseases and disorders of the central nervous system. The company’s drug product OMIDRIA®
(phenylephrine and ketorolac intraocular solution) 1% / 0.3% is marketed for use during cataract surgery or intraocular lens (IOL) replacement to maintain pupil size by preventing intraoperative miosis (pupil constriction) and to reduce
postoperative ocular pain. In the European Union, the European Commission has approved OMIDRIA for use in cataract surgery and other IOL replacement procedures to maintain mydriasis (pupil dilation), prevent miosis (pupil constriction), and to
reduce postoperative eye pain. Omeros has multiple Phase 3 and Phase 2 clinical-stage development programs focused on: complement-associated thrombotic microangiopathies; complement-mediated glomerulonephropathies; Huntington’s disease and
cognitive impairment; and addictive and compulsive disorders. In addition, Omeros has a diverse group of preclinical programs and a proprietary G protein-coupled receptor (GPCR) platform through which it controls 54 new GPCR drug targets and
corresponding compounds, a number of which are in preclinical development. The company also exclusively possesses a novel antibody-generating platform. 

Forward-Looking Statements 
 This press release contains
forward-looking statements within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934, which are subject to the “safe harbor” created by those sections for such
statements. All statements other than statements of historical fact are forward-looking statements, which are often indicated by terms such as “anticipate,” “believe,” “could,” “estimate,” “expect,”
“goal,” “intend,” “likely”, “look forward to,” “may,” “plan,” “potential,” “predict,” “project,” “should,” “will,” “would” and
similar expressions and variations thereof. Forward-looking statements are based on management’s beliefs and assumptions and on information available to management only as of the date of this press release. Omeros’ actual results could
differ materially from those anticipated in these forward-looking statements for many reasons, including, without limitation, risks associated with product commercialization and commercial operations, unproven preclinical and clinical development
activities, regulatory oversight, intellectual property claims, competitive developments, litigation, and the risks, uncertainties and other factors described under the heading “Risk Factors” in the company’s Annual Report on Form 10-K filed with the Securities and Exchange Commission on May 10, 2018. Given these risks, uncertainties and other factors, you should not place undue reliance on these forward-looking statements, and the
company assumes no obligation to update these forward-looking statements, even if new information becomes available in the future. 
 Contact: 

Jennifer Cook Williams 
 Cook Williams Communications, Inc. 

Investor and Media Relations 
 360.668.3701 

jennifer@cwcomm.org 
 28240867

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