Document:

EX-10.12

 Exhibit 10.12 

Evotec Version 1, 1st August 2019 
 THE SYMBOL
“[***]” DENOTES PLACES WHERE CERTAIN IDENTIFIED 
 INFORMATION HAS BEEN EXCLUDED FROM THE EXHIBIT BECAUSE IT IS BOTH 

(i) NOT MATERIAL, AND (ii) WOULD LIKELY CAUSE COMPETITIVE HARM TO 

THE COMPANY IF PUBLICLY DISCLOSED 

Drug Discovery & Development Services Agreement 

Evotec International GmbH 

and     

Novo Nordisk A/S 

 This agreement (“Drug Discovery & Development Services Agreement” or
“Agreement”) is by and between 
 Novo Nordisk A/S, Novo Allé, DK-2880, Bagsværd,
Denmark (“Novo Nordisk”) 
 and 
 Evotec
International GmbH, Manfred Eigen Campus, Essener Bogen 7, 22419 Hamburg, Germany Evotec (“Evotec”), 
 and is effective as of the date of
the last signature hereunder (“Executive Date”). 
 Novo Nordisk and Evotec are each referred to individually as a “Party”
and collectively referred to as the “Parties”. 
 Preamble 
  

	(A)	 Evotec has developed and acquired certain “Evotec Technology” relating to the Services” (as
hereinafter defined). 

  

	(B)	 Novo Nordisk is interested in purchasing Services from Evotec. 

 

	(C)	 Evotec is willing to provide such Services to Novo Nordisk. 

 

	(D)	 This Agreement sets forth the terms and conditions for purchase and use of the Services. 

NOW, THEREFORE, the Parties hereby acknowledge, and intend to be legally bound, and otherwise be bound by proper and reasonable conduct, agree as follows:

  

	1.	 Definitions 

For the purposes of this Drug Discovery & Development Services Agreement, all terms used with capital letters shall have the meaning assigned to such
terms in Section 1 below. 
  

			
		
	“Affiliates”	  	shall mean, with respect to either Party, any Person that controls, is controlled by or is under common control with such first Party. For purposes of this definition only, “control” means (a) to possess, directly or
indirectly, the power to direct the management or policies of a Person, whether through ownership of voting securities or by contract relating to voting rights or corporate governance, or (b) to own, directly or indirectly, more than fifty
percent (50%) of the outstanding voting securities or other ownership interest of such Person.
		
	Appendix (ces)	  	shall mean the appendix(ces) to this Agreement
		
	“Assay”	  	shall mean a testing system to detect the interaction of the Target(s) with the Compounds.
		
	“Assay Development”	  	shall mean the activities to be carried out by Evotec to develop, optimize or adapt an Assay to the Evotec Technology as more particularly described in the Project Description(s).

  
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	“Business Day”	  	shall mean every day of the week except Saturday, Sunday and nationally recognized holiday of DenmarkItaly or Germany.
		
	“Novo Nordisk Background IP”	  	shall mean all Intellectual Property Rights owned or Controlled by Novo Nordisk and licensed to Evotec by Novo Nordisk hereunder, such as all Intellectual Property Rights with regard to Novo Nordisk Compounds and Novo Nordisk
Materials to be applied by Evotec in the conduct of the Projects.
		
	“Novo Nordisk Compounds”	  	shall mean the physical samples or chemical structure information of substances provided to Evotec by Novo Nordisk upon which Evotec will perform Screening Services or other Services.
		
	“Novo Nordisk Material”	  	shall mean all physical samples supplied to Evotec by Novo Nordisk, including Novo Nordisk Compounds, Reagents and other materials to be used in the performance of the Services as detailed in the Project Description(s).
		
	“Compounds”	  	shall mean Novo Nordisk Compounds, Evotec Compounds and/or Project Compounds.
		
	“Computational Chemistry Services”	  	shall mean computational chemistry services to be performed by Evotec under this Agreement as specified in the Project Description(s), using Evotec’s computational chemistry tools.
		
	“Contract Term”	  	shall mean the period defined in Section 11.1.
		
	“Control(led)”	  	shall mean with respect to any Intellectual Property Right, that the Party controlling such right owns a transferable interest or has a license to practice such Intellectual Property Right and has the ability to grant the other
Party access, a license or a sublicense (as applicable) to practice such Intellectual Property Right.
		
	“DMPK Services”	  	shall mean in vitro and in silico DMPK services (Drug Metabolism and Pharmacokinetics services) and biological assay support as specified in the Project Description(s).
		
	“Evotec Background IP”	  	shall mean all Intellectual Property Rights owned or Controlled by Evotec relating to (i) the Evotec Technology and (ii) Evotec Compounds (that constitute part of the Evotec Libraries).
		
	“Evotec Compounds”	  	shall mean the physical samples of fragments and/or small molecules owned or Controlled by Evotec, with which Evotec will perform Screening Services or other Services.

  
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	“Evotec Libraries”	  	shall mean the libraries of Evotec Compounds or selections thereof kept by Evotec or any of its Affiliates.
		
	“Evotec Technology”	  	shall mean the processes, methodology or technology as employed by Evotec in the performance of the Services, including but not limited to, assay technology, the Evotec Libraries, software, algorithms, databases, screening
technology, structural biology technology, and chemical technology.
		
	“FTE”	  	shall mean the equivalent of a full time scientist of Evotec based on one thousand six hundred and fifty (1650) hours per year, carried out by one or, as the case may be, more scientists of Evotec, each of whom may devote a
portion of his or her time to the Project(s).
		
	“Intellectual Property Rights”	  	shall mean any discovery, invention, formulation, know-how, method, technological development, enhancement, modification, improvement, work of authorship, computer software (including, but not
limited to, source code and executable code) and documentation thereof, data or collection of data, whether patentable or not, or susceptible to copyright or any other form of legal protection.
		
	“In Vivo Services”	  	shall mean in vivo pharmacology activities to be performed by Evotec as mutually agreed between the Parties, including (i) single or multiple dose studies (ii) in vivo DMPK studies (iii) Pharmacodynamic studies in the
fields of CNS, diabetes, inflammation, obesity, oncology and pain (iv) In vivo profiling services, (v) dose-range finding studies (vi) tolerability studies and/or combinations thereof as specified in the Project
Description(s).
		
	“Licensee”	  	shall mean with respect to the Novo Nordisk any Person other than Novo Nordisk’s Affiliate(s), that is granted a license by the Novo Nordisk to develop, make, have made, use, offer for sale and sell product(s) derived from
Compounds.
		
	“Manufacturing Services”	  	means the manufacturing, quality control, quality assurance and stability testing, packaging and related services, as contemplated in this Agreement, required to produce the Deliverables.
		
	“Medicinal Chemistry Services”	  	shall mean activities undertaken by Evotec to perform synthetic services to synthesise and/or acquire Project Compounds in order to optimise their properties as specified in the Project Description(s).

  
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	“Person”	  	shall mean any individual, corporation, association, partnership (general or limited), joint venture, trust, estate, limited liability company, limited liability partnership, unincorporated organization, government (or any agency or
political subdivision thereof) or other legal entity or organization.
		
	“Preclinical Services”	  	shall man all in vivo and in vitro studies to support regulatory filing applications, drug product formulation, drug product manufacture and drug substance manufacture.
		
	“Profiling Services”	  	shall mean the additional characterization of Compounds that interact with the Target(s) as more particularly described in the respective Project Description(s), including dose response studies or other secondary testing and re-testing, and DMPK testing.
		
	“Project(s)”	  	shall mean the individual Services to be provided and performed by Evotec for Novo Nordisk.
		
	“Project Compounds”	  	shall mean a discrete organic chemical entity (i) developed and physically produced or (ii) the physical samples acquired from a third party under this Agreement—all as delivered to Novo Nordisk and/or used within any
Services.
		
	“Project Deliverables”	  	shall mean, with respect to each Project, the data, information, reports, Project Compounds, and other items set forth in the Project Description of such Project to be delivered by Evotec to Novo Nordisk in connection with the
performance by Evotec of the Services specified in such Project Description.
		
	“Project Description”	  	shall mean with respect to each Project, the written document to be attached to this Agreement as an Appendix prepared in accordance with Section 2.
		
	“Project IP”	  	shall mean all Intellectual Property Rights conceived, discovered, invented or made by Evotec or Novo Nordisk during the course of the performance of the Services in the conduct of the Projects other than Evotec IP (as defined in
Section 10.5).
		
	“Project Leader	  	shall mean for each Project, the project manager or designated person who is overall responsible to scientifically manage the Project.
		
	“Public Domain Target”	  	shall mean a Target which can be freely used without infringing Intellectual Property Rights.

  
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	“Reagent”	  	shall mean chemicals, proteins, antibodies, dyes, cells, conjugates or suchlike that are needed to perform Assay Development, Screening Services Profiling Services or other Services – other than Compounds.
		
	“Reagent Development”	  	shall mean the activities performed by Evotec relating to the preparation of Reagents detailed in the respective Project Description(s).
		
	“Screening Services”	  	shall mean the primary and/or secondary screening activities including the provision of the Evotec Library, as described in the respective Project Description(s), to be carried out by Evotec to identify whether the Compounds
interact with the Target(s) as more particularly described in the respective Project Description(s).
		
	“Section(s)”	  	shall mean the section(s) to this Agreement.
		
	Services”	  	shall mean drug discovery and development activities to be performed by Evotec as mutually agreed between the Parties, including (i) Reagent Development, (ii) Assay Development, (iii) Screening Services,
(iv) Profiling Services, (v) Structural Biology Services, (vi) Medicinal Chemistry Services, (vii) Computational Chemistry Services, (viii) In Vivo Services, (ix) DMPK Services, (x) Preclinical Services and/or
(xi) Manufacturing Services and/or combinations thereof.
		
	“Steering Committee”	  	shall mean the committee set up by the Parties in accordance with Section 3.
		
	“Structural Biology Services”	  	shall mean structural biology activities to be performed by Evotec under this Agreement as specified in the Project Description(s), including e.g. crystallization, X-ray analysis or NMR
analysis.
		
	“Sub-Licensee”	  	shall mean with respect to the Novo Nordisk, any Person that is granted a sub-license by the Novo Nordisk to develop, make, have made, use, offer for sale and sell product(s) derived from the
Compounds.
		
	“Target”	  	shall mean a specific biological target to be used in the performance of the respective Screening Services or other Services as detailed in the respective Project Description(s).
		
	“Technical Information Disclosure Package”	  	shall mean the necessary information for Evotec for the performance of a specific Project, to be provided by Novo Nordisk for the purposes of a specific Project as agreed between the Parties.

  
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	“Third Party”	  	shall mean any Person other than Evotec, Novo Nordisk and their respective Affiliates.
		
	“Term”	  	shall mean the term of this Agreement as defined in Section 11.1.

 References. Unless the context otherwise requires, all references to a particular Section or Appendix shall be a
reference to that Section or Appendix, in or to the Agreement or Appendices as the same may be amended from time to time. 
 Headings. Headings are
inserted for convenience only and shall have no effect on the meaning of the provisions thereof. 
 Appendices. The Appendices form part of this
Agreement and have the same force and effect as if expressly set out in the body of the Agreement. Any reference to the Agreement includes the Appendices. Any breach of the Appendices shall be deemed as a breach of this Agreement. 

 

	2.	 Project Descriptions 

 

	2.1	 Project Descriptions. Upon request of Novo Nordisk, Evotec shall propose a project description for the
planned project. Each proposed project description developed by Evotec shall include the following information: (i) a reasonably detailed description of the Services to performed by Evotec; (ii) an estimated time frame for the completion
of such proposed project; (iii) the Project Deliverables; (iv) pricing and payment schedule; and (v) other information which may be necessary to appropriately describe the Services to be performed by Evotec in respect of such proposed
project, e.g. the number of FTEs. 

  

	2.2	 Adoption of Proposed Projects by the Parties. The Parties hereby agree that each proposed project and
proposed Project Description shall only be confirmed under this Agreement upon the written approval of both Parties. After such approval, the Parties hereby agree that (i) such proposed project will be deemed a “Project” for the
purposes as that term is defined in this Agreement; and (ii) such proposed Project Description will be deemed attached to, and part of, this Agreement. 

  

	2.3	 Reports. Evotec shall deliver (i) interim project reports (the “Interim Project
Reports”) and (ii) final project reports (the “Final Project Reports”) to Novo Nordisk’s Project Leader as specified in each Project Description. (Interim Project Reports and Final Project Reports are collectively
referred to as “Project Report(s)”). 

 Each Project Report shall provide (i) a summary of the status
and progress of each Project, (ii) results, material developments and issues in respect to each Project and (iii) such other matters related to each Project as reasonably requested by the Steering Committee in accordance with
Section 3.2. 
  

	3.	 Program Management 

 

	3.1	 Setting up the Steering Committee(s). Novo Nordisk and Evotec shall establish a Steering Commitee, which
shall be composed of a minimum of two (2) people from each Party, with an equal number of members from each Party, and shall meet on at least a quarterly basis at times to be agreed between the Parties (i) alternating between both
Parties’ sites, or (ii) by video conference, or (iii) by telephone conference (contact type to be mutually agreed between the Parties). Each Party shall be responsible for all travel and related expenses it may incur for the Steering
Committee meetings. The Parties will share as equally as possible the cost and effort of providing administrative support to the Steering Committee, setting meeting agendas, keeping minutes of meetings, and otherwise assuring the operation of the
Steering Committee. 

  
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	3.2	 Obligations of the Steering Committee. The Steering Committee will have the obligation to manage and
review the progress of the Project(s). In particular, the Steering Committee shall: 

  

	 	3.2.1	 Co-ordinate the activities of the Parties in relation to the
Project(s); 

  

	 	3.2.2	 Monitor the progress of the Project(s) and the Parties’ diligence in carrying out their responsibilities;
and 

  

	 	3.2.3	 Agree on type, format and contents of Project Reports to be provided by Evotec to Novo Nordisk in accordance
with the agreed-upon Project(s). 

  

	3.3	 Voting. The Steering Committee will take action by unanimous vote with each Party having a single
vote, irrespective of the number of representatives a Party has on the Steering Committee. The Parties agree that, in voting on matters as described in this Section 3.3, it shall be conclusively presumed that each representative voting on
behalf of each Party in the Steering Committee has the authority and approval of such member’s respective senior management in casting his or her vote. 

  

	3.4	 Decision-Making. The Steering Committee will attempt to resolve matters by unanimous agreement. However,
in a case where the Steering Committee cannot resolve a matter unanimously, it will be referred to senior management of Novo Nordisk and Evotec. In the event that an agreement cannot be reached by senior management within fourteen (14) days
from the date of inquiry, Novo Nordisk will have the final decision on the matter, unless the decision would result in (i) extending the Services provided by Evotec hereunder beyond what has been agreed to by the Parties (ii) altering the
scope of Services leading to additional costs for Evotec, unless Novo Nordisk agrees to adjust payments to Evotec to cover such extended Services or additional costs, or (iii) unreasonable alterations in Evotec’s Project-specific
costs calculations, unless Novo Nordisk agrees to cover such unreasonable alterations. 

  

	3.5	 Project Leader(s). Evotec and Novo Nordisk shall each appoint a scientific project leader for each
Project, who will serve as the principal point of contact between the Parties for each Project. Evotec’s Project Leader shall keep Novo Nordisk’s Project Leader fully informed of the progress of the particular Project. Evotec shall ensure
that its Project Leader is reasonably available for telephone and face-to-face discussions with Novo Nordisk’s personnel. Evotec’s Project Leader shall report
at least once every two weeks to Novo Nordisk’s Project Leader (with or without participation of project teams) in person, by video, telephone or electronic communication. 

 

	3.6	 Changes. For the avoidance of doubt, the Steering Committeeand the Project Leaders shall not be
authorized to amend this Agreement or the Appendices. 

  

	3.7	 Visiting Professionals. Novo Nordisk may invite additional representatives to attend meetings of the
Steering Committee. All such representatives will be bound by terms and conditions equivalent to those of this Agreement. Voting will be in accordance with Section 3.3 

 

	4.	 Performance of the Services 

 

	4.1	 Performance of Projects. The Parties shall collaborate to perform each Project which shall comprise the
provision of Services as specified in the respective Project Description(s). 

  
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	4.2	 Obligations of the Parties. The Parties shall: 

 

	 	a)	 use reasonable efforts to carry out their respective obligations under this Agreement; and

  

	 	b)	 perform their respective obligations under this Agreement with all due skill, care and diligence, in a timely
and professional manner, and in accordance with the estimated timetable mutually agreed between both Project Managers, the Steering Committee and/or in the respective Project Description(s). 

 

	4.3	 No Guarantee of Outcome. The Parties acknowledge that, as with all research and development projects, it
is not possible to guarantee that any Project will be successful or completed within a specified time-scale, or at all. In particular, it is not possible to guarantee that the Assay Development will result in a useful Assay, that the Screening
Services and Profiling Services will generate any hits or the Medicinal Chemistry Services any leads. Accordingly, Evotec shall not be liable for failure of any Project to generate any useful results provided that Evotec has used reasonable efforts
to carry out its obligations under this Agreement in accordance with Section 4.2 and has adhered to the expressed and mutually agreed Project Description(s) in the performance of Services of each respective Project. 

 

	4.4	 Re-allocation of FTEs. The Steering Committee shall have the
right to re-allocate any or all of the FTEs being sponsored by Novo Nordisk hereunder to perform any of the various Services covered under the Agreement; provided, however, that such re-allocation shall take effect at a reasonable time to be mutually determined by the Parties but in no event any later than sixty (60) days from the Steering Committee’s date of decision.

  

	4.5	 Pursuant to the terms and conditions of this Agreement, Evotec will apply to the Services at its site in Verona
the then-current and applicable Good Manufacturing Practices, Good Clinical Practices and/or Good Laboratory Practices. 

  

	5.	 Novo Nordisk Materials 

 

	5.1	 Providing Novo Nordisk Materials. Novo Nordisk shall provide Novo Nordisk Materials to Evotec free of
charge in accordance with the timetable and the specification set out in each respective Project Description(s), and to the extent mutually agreed between the Parties as being necessary for the performance of a Project(s) by Evotec hereunder.

 Novo Nordisk hereby represents that to Novo Nordisk’s knowledge, it shall have the right to transfer, or has
transferred, all such Novo Nordisk Materials to Evotec for the purposes of performing the Services in each respective Project. 
 Novo
Nordisk hereby further represents that such Novo Nordisk Materials provided to Evotec will be provided in compliance with all applicable federal, state, local and international laws, rules, regulations, orders and guidelines. In accordance with
Section 9.5 of this Agreement, Novo Nordisk shall inform Evotec of any safety hazard that relates to any of the Novo Nordisk Material. 
  

	5.2	 Property of Novo Nordisk Materials. Novo Nordisk Materials shall remain the exclusive property of Novo
Nordisk. Evotec shall use Novo Nordisk Materials solely for the purpose of carrying out its obligations under this Agreement. 

  

	5.3	 Use of Novo Nordisk Materials. Evotec shall not provide any of Novo Nordisk Materials, or any
information associated with Novo Nordisk Materials to any Third Party. Evotec may provide such Novo Nordisk Materials to its Affiliates and to Services Sub-Contractors as defined and in accordance with
Section 13.8 for providing Service. Evotec shall not use Novo Nordisk Materials in humans, animals, or plants, or for any purpose other than the Project’s purpose. 

  
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 Except to the extent required to enable Evotec to perform the Drug Discovery Services,
Evotec hereby further agrees that it will not, directly or indirectly, reverse engineer, deconstruct or in any way analyze or determine the identity, structure or composition of any Novo Nordisk Materials or the properties thereof (chemical,
biochemical, physical, biological or other). 
  

	5.4	 Retention of Novo Nordisk Materials. Unless otherwise agreed or directed by Novo Nordisk in writing (or,
in case of other obligations of Evotec for Novo Nordisk Materials provided by Third Parties on behalf of Novo Nordisk under separate agreements with Evotec), Evotec shall retain all unused Novo Nordisk Materials for a period of six (6) months
(“Retention Period”). Upon the expiration of such Retention Period, Evotec shall return or appropriately discard or destroy all such unused Novo Nordisk Materials as directed by Novo Nordisk. Upon request, an authorised officer of
Evotec shall confirm in writing its compliance with this Section. In case Novo Nordisk Material is provided to Evotec on behalf of Novo Nordisk by Third Parties under separate agreements between Third Parties and Evotec, these agreements may require
the return of such Novo Nordisk Material to the providing Third Party. For the avoidance of doubt, in such a case, these agreements shall prevail with respect to Evotec’s obligation to return, discard or destroy the unused Novo Nordisk
Materials as set forth in Section 5.4 (second sentence). 

  

	6.	 Confidential Information 

 

	6.1	 “Confidential Information” shall mean all Novo Nordisk Background IP, Evotec Background IP,
Project IP, Evotec IP disclosed by one Party to the other Party under this Agreement or other proprietary business, technical and/or research information. 

  

	6.2	 “Confidential Information” shall not include any information which: 

 

	 	6.2.1	 is or becomes public knowledge through no improper conduct on the part of the Party receiving the Confidential
Information; and/or 

  

	 	6.2.2	 is already lawfully possessed by the Party receiving Confidential Information prior to receiving it; and/or

  

	 	6.2.3	 is obtained subsequently from a Third Party without any obligations of confidentiality and such Third Party is
in lawful possession of such information and is not in violation of any contractual or legal obligation to maintain the confidentiality of such information; and/or 

 

	 	6.2.4	 is independently developed by the Party receiving the Confidential Information, as evidenced by such
Party’s written records, without use or reliance upon such Confidential Information; 

  

	 	6.2.5	 is approved for release by written authorization of the original Party disclosing the Confidential Information.

  

	6.3	 Exceptions. For the purpose of Section 6.2, no information which is specific shall be deemed to be
within any of the exceptions, stipulated in Section 6.2, merely because it encompasses more general information which falls within one or more of the foregoing exceptions. 

 

	6.4	 Onus to demonstrate. The onus to demonstrate that any of the exceptions set out in Section 6.2
applies shall fall on the asserting Party. 

  
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	6.5	 Disclosure of Confidential Information. Each Party shall keep, and shall cause its respective employees,
directors, auditors, agents, consultants, and Affiliates to keep confidential all Confidential Information belonging to the other Party and shall not use any Confidential Information belonging to the other Party for purposes other than carrying out
the Project(s) and/or exercising its rights hereunder. 

  

	6.6	 Permitted Disclosures. In the event any Party determines that it is required by law or by a regulatory
authority having jurisdiction to disclose any Confidential Information, whether by way of public filing or otherwise, then that Party shall promptly give written notice thereof to the other Party and (subject to such law or regulatory authority)
permit the other the right to review such disclosure, obtain a protective order or to terminate any further discussions. Disclosures made under this paragraph shall not otherwise exempt the disclosed Confidential Information from protection under
this Agreement. 

  

	6.7	 Confidentiality Term. The requirements of this Section 6 shall continue in effect for a period of
seven (7) years, with the exception set forth in Section 10.3 b), following expiration or Term of this Drug Discovery & Development Services Agreement or the expiry of the exclusivity period defined in
Section 10.4 (whatever is later 

  

	7.	 Publicity and Company Names 

 

	7.1	 Press Releases. In the event Evotec or Novo Nordisk wish to publish a press release relating to this
Agreement, either Party will contact the other Party to discuss the possibility of a release, and such other Party will give reasonable consideration to the request. 

In any event, both Parties agree not to issue any press releases without written approval from the other Party. 

 

	7.2	 Neither the Novo Nordisk nor Evotec shall produce or make public, any forms of advertising, sales literature or
other written or oral statements in connection with, or alluding to: 

  

	 	a)	 work performed under this Agreement or the relationship between the Parties created by it, having or containing
any reference to the names of Novo Nordisk or Evotec; 

  

	 	b)	 work having or containing the logos, trademarks or service marks, alone or as part of another name or mark,
without the prior written approval of an authorized representative the other Party. 

  

	8.	 Delivery and Payments 

 

	8.1	 Project Costs. All Project costs and fees will be invoiced by Evotec as specified in the particular
Project Description on an FTE or non-FTE basis as the case may be. All sums specified in the Project Description are exclusive of Value Added Tax or any other sales tax or duties. Where applicable, the
foregoing shall be payable to Evotec by the Novo Nordisk. All sums payable under this Agreement shall be paid in EURO unless otherwise specified in the respective Project Description. Payments shall be made by direct wire transfer within forty-five
(45) days of the date of invoice. Any payment payable by Novo Nordisk hereunder is subject to receipt by Novo Nordisk of an invoice prepared in accordance with the Novo Nordisk invoicing instructions set forth in APPENDIX 1.

  

	8.2	 Delivery. Title to and all risk in each Project Deliverable shall pass to Novo Nordisk on an
Evotec’s Ex-Works (Hamburg/Abingdon/Manchester/Munich/Goettingen/Toulouse - as the case may be) (Incoterms 2010) basis. 

Notwithstanding the foregoing, unless requested otherwise by Novo Nordisk, Evotec shall act as an agent to arrange shipping of all Project
Deliverables to Novo Nordisk or any designee and shall insure such Project Deliverables during shipment in accordance with Novo Nordisk’s instructions. 

  
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 For the avoidance of any doubts, both Parties agree, that payments are payments for research
services, including associated costs. In case that reagents, Active Pharmaceutical Ingredients (API) etc. need to be send between the Parties, as part of the research activities, those will be send from Evotec, including its sites mentioned above,
based on Ex-Works (Incoterms 2010). 
  

	8.3	 Licenses. If (a) license(s) from a Third Party is (are) required to perform the Project(s) and
payment to such Third Party for such license(s) is required, Novo Nordisk shall be notified of, and shall make a decision as to (i) obtain said license(s) which would enable Evotec to perform such Project(s), to the extent specified in the
respective Project Description(s);or (ii) exclude those Services from the Project(s) that would require such Third Party license(s). If Novo Nordisk determines to obtain said license(s), then Novo Nordisk shall bear the cost of said license(s).
If Novo Nordisk elects said exclusion or cessation, the amount payable by Novo Nordisk to Evotec shall be reasonably adjusted according to such exclusion or cessation. 

 

	8.4	 Interest. If Novo Nordisk fails to pay any sum due under this Agreement in full by the due date for
payment, then Evotec may, without prejudice to any other available right or remedy, charge interest on any outstanding amount on a daily basis at a rate equivalent to LIBOR six (6) months plus two percent (1%), or, if lower, the highest rate
permitted under applicable law. 

  

	8.5	 Withholding Tax. All sums payable under this Agreement shall be paid in full without any deductions
(including, but not limited to, deductions in respect of items such as income, corporation, or other taxes, charges and/or duties) except insofar as Novo Nordisk is required by law to deduct withholding tax from sums payable to Evotec. If Novo
Nordisk is required by law to deduct withholding tax, then Novo Nordisk and Evotec shall co-operate in all respects and take all reasonable steps necessary to (i) lawfully avoid the making of any such
deduction or (ii) to enable Evotec to obtain a tax credit in respect of the amount withheld. 

  

	9.	 Warranties 

  

	9.1	 Representations and Covenants of the Parties. The Parties hereby agree to each of the following:

  

	 	9.1.1	 Compliance with Law. The Services will be conducted in compliance with all applicable federal, state,
local, international, health authority and institutional laws, rules, regulations, orders and guidelines. Each Party shall do all things necessary to obtain, in a timely manner, all licenses and approvals required to conduct the Services.

 Novo Nordisk acknowledges that only electronic laboratory notebooks will be kept for all work conducted at
Evotec’ssites in Hamburg, Munich and Goettingen (Germany); Manchester and Abingdon (UK) and Toulouse (France) and that Novo Nordisk will receive only excerpts from such laboratory notebooks. 

 

	 	9.1.2	 Conflicting Obligations. Neither Party has, to its knowledge, granted any right or entered into any
agreement or understanding with any Third Party that conflicts with either Party’s obligations or rights under this Agreement, nor will either Party do so during the term of this Agreement. 

  
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	 	9.1.3	 Further Assurances. Each Party shall execute such further documents, instruments, and assurances, and
take such further actions as the other Party may reasonably request from time to time to better enable the other Party to exercise its rights under this Agreement. 

 

	9.2	 Assignment of Rights. As far as permissible by the applicable law, Evotec warrants that each of its
employees, students, representatives, agents, consultants, allowed Sub-contractors (in accordance with Section 13.8) or any other Person engaged in performing the Services has entered or will enter into
an agreement which provides for the assignment to Evotec of all Project IP made, conceived of or reduced to practice by such employee, student, representative, agent, consultant, allowed Sub-contractor or any
other Person in the performance of the Services under this Agreement . Unless agreed otherwise or other than those that may be specifically listed or referenced herein, no license or other Intellectual Property Right to Project IP is granted to
Evotec by implication or otherwise, by virtue of this Agreement. All use of Project IP by Evotec or its employees, representatives, agents, consultants, allowed Sub-contractors or any other Person engaged in
performing the Services will at all times inure to the benefit of Novo Nordisk. 

  

	9.3	 Skills and training. Evotec will ensure (i) that its staff employed in providing the Services have
the necessary skills and training to provide the Services, and (ii) that Evotec’s facilities and equipment used by the staff to provide the Services are of an appropriate standard. 

 

	9.4	 Exclusion of Warranties. Except as set forth herein, all warranties implied by law (whether by statute,
common law, trade usage, custom or otherwise) are hereby excluded for Evotec to the maximum extent permitted by law.  

Without limitation to the generality of Section 9.1-9.3, Evotec gives no warranty that the Evotec
Compounds or Project Compounds: 
  

	 	a)	 are fit for any purpose; 

 

	 	b)	 are safe for use in connection with humans, animals or plants; 

 

	 	c)	 are non-toxic; 

 

	 	d)	 are non-hazardous; 

 

	 	e)	 are new or have never been published; and/or 

 

	 	f)	 do not infringe the Intellectual Property Right of any Third Party nor that the production or use of the Evotec
Compounds or Project Compounds will not infringe the Intellectual Property Right of any Third Party. 

  

	9.5	 Safety Hazards. If either Party becomes aware of any safety hazards that relate to any of the
deliverables, it shall promptly notify the other Party by providing all information in its possession or control concerning such safety hazards. 

  

	10.	 Ownership of Intellectual Property 

 

	10.1	 Ownership of Project IP. Subject to Sections 10.3 and 10.4, Novo Nordisk shall own all Project IP and
Evotec hereby assigns all Project IP to Novo Nordisk as far as permissible by applicable law. To the extent any rights in the Project IP cannot be assigned to Novo Nordisk by Evotec, Evotec hereby grants to Novo Nordisk a perpetual, irrevocable,
worldwide, royalty-free, exclusive, transferable license with the right to sublicense through multiple tiers to practice such non-assignable rights in any manner for any purpose. Evotec shall have no ownership
or other interest in any Project IP. Upon the reasonable request of Novo Nordisk, Evotec shall execute such documents deemed necessary by Novo Nordisk and assure that all ownership or other interests of the Project IP vest in Novo Nordisk. Novo
Nordisk shall reimburse Evotec for all reasonable out-of-pocket costs and expenses actually incurred by Evotec to execute and deliver to Novo Nordisk any such document
referred to immediately above. 

  
 page 13 of 22 

	10.2	 Notification and Delivery of Project IP. Evotec shall inform Novo Nordisk of, and deliver, all Project
IP to Novo Nordisk through the Project Reports or as otherwise agreed. 

  

	10.3	 Structures. 

For clarity, the spatial pattern of a crystallized Target or complexes of such Target with Compounds characterized
(“Structures”) e.g. by X-ray analysis or NMR analysis generated from the performance of Structural Biology Services under this Agreement shall be considered Project IP. 

In case and as long as the Target and/or the Compounds are exclusively owned or Controlled by Novo Nordisk, Evotec will not perform Structural
Biology Services to Third Parties on such Target and/or Compounds.  
 Notwithstanding the foregoing, Evotec shall be free to
perform Structural Biology Services on the Public Domain Target either alone with no ligands bound or within complexes with any ligands other than Compounds owned or Controlled by the Novo Nordisk. 

For the avoidance of doubt, in case the Target is a Public Domain Target but a Compound is owned or Controlled by the Novo Nordisk, Evotec
shall be free to perform Structural Biology Services on such Target on compounds other than the Compound owned or Controlled by the Novo Nordisk. 

In case the Structure of a particular Public Domain Target is owned or Controlled by Evotec, Evotec will grant to Novo Nordisk a non-exclusive, fully paid up, worldwide, perpetual, irrevocable, sub-licensable and assignable license to use such Structure of the Public Domain Target to the extent
necessary to develop and commercialize Project IP. 
  

	10.4	 Certain Project Compounds. Excluded from Project IP shall be the composition of matter of
(i) Project Compounds re-synthesized from the Evotec Libraries, (ii) Project Compounds acquired from Third Party Evotec(s), or (iii) Project Compounds which are or become part of the public
domain or the prior art at or after the date of first shipment of compounds, other than through Evotec’s breach of its confidentiality obligations under this Agreement. 

Compound Exclusivity. All Project Compounds, other than those excluded in Section 10.4 paragraph 1, shall be exclusive to Novo
Nordisk for a period of [***] from the date of first shipment of such Project Compound. At the expiration of such exclusivity period for a given Project Compound, Evotec’s confidentiality obligation as set forth in Section 6.7 with regard
to such Project Compound as composition of matter shall end. For the avoidance of doubt, with the exception of the regulation set out in the preceding sentence, Evotec’s confidentiality obligations towards Novo Nordisk regarding all other Novo
Nordisk Confidential Information shall continue as outlined in Section 6 and by way of example, Evotec shall not be permitted to use any know-how which is part of the Project IP for screening with any
third party Targets. 
 Restrictions. The screened Evotec Compounds shall not be screened against the same Target for any third party other
than Novo Nordisk and Evotec represents and warrants that it has and shall have sufficient operational procedures in place to prevent any such screening from occurring. For clarity, Evotec agrees and acknowledges that the physical Project Compound
samples used under this Agreement shall not be used by Evotec for any third Party. 

  
 page 14 of 22 

	10.5	 Ownership of Evotec IP. Evotec shall own (i) all Evotec Background IP and/or (ii) all
Intellectual Property Rights relating to generally applicable technology, methodology or processes essentially developed by Evotec, including all improvements, variations, modifications or enhancements of the Intellectual Property Rights described
in (i) and (ii) conceived, discovered, invented or made by Evotec during the performance of Services hereunder (referred to as “Evotec IP”). Novo Nordisk shall have no ownership or other interest in any Evotec IP. No rights to
Evotec IP are granted under this Agreement, unless explicitly stated hereunder or mutually agreed otherwise in writing on a case-by-case basis. 

Evotec will not in any way seek to rely on any Evotec IP which it may have to prevent Novo Nordisk from exercising any right or using the
Project IP or Structures owned by the Novo Nordisk under this Section 10. 
 Novo Nordisk acknowledges that Evotec does not guarantee
that a Third Party has not filed any patent application or will not file any patent application on any Project Compound, hit, or their manufacture, use or formulation. 
  

	10.6	 Ownership of Novo Nordisk Background IP and Project IP and license. Novo Nordisk shall own all Novo
Nordisk Background IP and Project IP. Evotec shall have no ownership or other interest in any Novo Nordisk Background IP. Novo Nordisk grants to Evotec a limited non-exclusive, royalty-free, non-transferable, sub-licensable license to use Novo Nordisk Background IP solely for the purposes of carrying out its obligations under this Agreement. The limited non-exclusive, royalty-free, non-transferable, sub-licensable license expires either the day that the particular Project is completed
or the last day of this Agreement, whichever day occurs first. 

  

	10.7	 Know-How in the Public Domain. Nothing contained in this
Agreement shall restrict, hinder or prohibit the right of either Party to use any know-how, data or information of the other Party which is freely available and in the public domain. 

 

	10.8	 Support. Novo Nordisk shall have the exclusive right but not the obligation to initiate and file for
patent, prosecute, maintain and defend any and all patentable ideas and concepts with respect to Project IP that it owns (exclusively pursuant to this Agreement). Evotec will report in writing to Novo Nordisk any and all Project IP through the
Project Reports or as otherwise agreed. 

 Evotec agrees to assist Novo Nordisk, at Novo Nordisk’s expense, to obtain
and from time to time enforce and defend Project IP in any and all countries, and to execute all documents reasonably necessary for Novo Nordisk or any designee to do so. 
  

	10.9	 Rights. Each Party shall have the right to grant, sell, license or otherwise transfer in whole or in
part any of the Intellectual Property Rights which it owns in accordance with the terms and conditions of this Agreement. 

  

	10.10	 No Implied Rights. Except as provided in this Agreement, no express or implied licenses or other rights
are provided by either Party to the other under any patents, patent applications, trade secrets or other proprietary rights of a Party herein. 

  
 page 15 of 22 

	11.	 Term and Termination 

 

	11.1	 Term of Drug Discovery & Development Services Agreement. This Drug
Discovery & Development Services Agreement shall become effective on the Effective Date and shall continue in effect for a period of two (2) years unless renewed by the Parties or terminated in accordance with Section 11.3 below.

  

	11.2	 Termination of Projects. 

 

	 	11.2.1	 Subject to Section 11.2.2, either Party to a particular Project may only terminate such Project in the
event of material breach of any of its essential requirements by the other Party and failure of the other Party to remedy such breach within thirty (30) days of receipt of written notice specifying the breach (or, if the breach cannot
reasonably be remedied within such thirty (30) day period, failure by the other Party to make good faith efforts diligently to pursue completion of remedy). 

The Parties agree that the Project objectives as defined in the individual Project(s) are target objectives. Evotec’s ability to fulfill
these objectives inter alia depends at least partly on the technical parameters defined from time to time by the Steering Committee. Evotec and Novo Nordisk agree that any failure to meet the defined Project objectives shall not be deemed a
material breach of Evotec’s obligations under the Projects, provided that Evotec uses reasonable efforts to fulfill the Project objectives in accordance with Section 4, including Evotec’s adherence to the expressed and mutually agreed
Project Descriptions in the performance of Services of each respective Project. 
  

	 	11.2.2	 The Parties may agree to terminate a particular Project with immediate effect or in accordance with a specific
schedule if the Parties mutually agree that the Project is technically not feasible. 

  

	 	11.2.3	 Novo Nordisk may terminate a particular Project without cause by providing Evotec with forty-five
(45) days prior written notice. 

  

	 	11.2.4	 Termination of a specific Project will be effective only as to such specific Project, as the case may be, and
shall not affect the validity of this Agreement or the continuation of other Projects; provided however, that such reason for termination by a Party in a specific Project is not tantamount to a material breach of this Agreement. In such case,
either Party may have the right to terminate this Agreement pursuant to Section 11.3.1 below. 

  

	 	11.2.5	 Novo Nordisk shall have the right to cancel any preclinical or development Service/ portion of Service or
‘Proposal’ amended under this Agreement at any time with formal written notice to Evotec. 

  

	 	a)	 Cancellation or postponing pre-booked animal study slots: In the event
that Novo Nordisk requests to cancel or post-pone (by more than 15 working days) a pre-booked animal study slot, Evotec will make all commercially practical efforts to fill that slot. 

 

	 	b)	 For in-life animals studies, Novo Nordisk shall also pay a cancellation
fee as follows: 

  

	 	•	 	 If the cancellation occurs within 60 days of the start date of the
in-life study, Novo Nordisk agrees to pay Evotec [***]% of the overall study price detailed in this proposal. 

  
 page 16 of 22 

	 	•	 	 If the cancellation occurs within 30 days of the start date of the
in-life study, Novo Nordisk agrees to pay Evotec [***]% of the overall study price detailed in the proposal. 

  

	 	c)	 In the event that Novo Nordisk requests to post-pone the pre-booked
slot by more than 15 working days from the planned start date, Novo Nordisk may pay a rescheduling fee of [***]% of the price detailed in this proposal. In the avoidance of doubt postponement is not to be regarded as a cancelation and subsequent
rebooking. 

 Should it be necessary to terminate the study prior to the planned completion date, due to any unexpected
adverse events (for example, dosing results in toxic effects leading to, either the death or the euthanasia of the animal on welfare grounds) then Novo Nordisk will be notified immediately and Novo Nordisk shall be responsible for payment for all
work completed (including cost of animals and fees related to the maintenance of them, purchase of materials, waste disposal fees etc.) and for any additional work and associated costs necessary to come to a mutually agreeable stopping point The
associated fees will be re-conciliated in a change order as agreed in advance with Novo Nordisk. 
  

	11.3	 Termination of Drug Discovery & Development Services Agreement.

  

	 	11.3.1	 Evotec or Novo Nordisk may only terminate this Agreement immediately by giving written notice to
the other Party in the event Evotec or Novo Nordisk (a) files a petition in bankruptcy or is adjudicated as bankrupt or insolvent under applicable law; or if a petition in bankruptcy is filed against such Party and that proceeding is not
terminated within one hundred twenty (120) days of being instituted; (b) makes an assignment for the benefit of creditors; (c) applies for or consents to the appointment of an administrator, administrative receiver, or receiver or
similar official appointed over the whole or any significant part of its business and assets and is unable to pay its debts generally as they become due; or (d) makes an order or passes or proposes a resolution for winding-up Evotec or Novo Nordisk (except for the purposes of a valid amalgamation or reconstruction), or upon or after the breach of any material provision of this Agreement by the other Party.

  

	 	11.3.2	 Novo Nordisk may terminate this Agreement immediately by giving written notice to Evotec upon an Evotec Change
of Control (defined in Section 13.2). 

  

	 	11.3.3	 Novo Nordisk may terminate this Agreement on 180 days written notice without cause. 

 

	 	11.3.4	 With respect to each Project and subject to Section 11.2.3 above, this Drug Discovery &
Development Services Agreement will in any event remain in force until the respective Project expires or is terminated. 

  

	11.4	 General Effects of Termination. The termination of this Drug Discovery & Development Services
Agreement or any individual Project shall not affect the obligations of either Party in relation to activities which have been rendered or payments made by a Party prior to such termination, including without limitation, Novo Nordisk’s
ownership rights to Project IP and Evotec’s obligation to assign all Project IP to Novo Nordisk as further expressed in Section 10.4 herein up to the time of termination. 

  
 page 17 of 22 

 All provisions of this Agreement which must survive in order to give effect to its meaning
will survive termination or expiration of this Agreement. 
 The provisions of Section 6 (Confidential Information) shall survive the
expiration or termination of this Agreement in accordance with Section 6.7. 
 11.5 Specific Effects of Termination. 

 

	 	11.5.1	 Termination of this Agreement or an individual Project shall be without prejudice to any rights of action which
may have accrued to either Party. Evotec will invoice to Novo Nordisk all costs for Drug Discovery & Development Services completed and irrevocable costs incurred by Evotec in accordance with this Agreement and/or the particular Project
Description prior to the effective date of termination (e.g. raw materials or Reagents ordered, the reservation of screening slots). Additional payments may be due in accordance with the Project Description(s). 

 

	 	11.5.2	 Subject to Section 11.2.3 and 11.3.2, upon termination, all rights and obligations of the Parties under
this Agreement or one or more individual Projects, as the case may be, shall terminate unless specified in this Agreement or the individual Project(s) to survive termination, except for Novo Nordisk’s ownership rights and Evotec’s related
obligations in accordance with Section 10.4 and 11.4, and Novo Nordisk’s obligation to pay Evotec for any amounts due in accordance with Section 11.5.1. 

Upon termination of this Agreement or an individual Project by Evotec or Novo Nordisk for any reason, the Parties shall, in good faith,
work out a transition plan to wind down their respective work, return materials to each other, complete and deliver required reports and accountings, and settle any other outstanding issues; provided that, it is agreed that each Party is
obligated to return to the other Party, or destroy, upon the written request of the other Party, all Confidential Information of the other Party in its possession, and in the case of Evotec, Novo Nordisk Materials. 

 

	 	11.5.3	 In case of termination or expiry of the Agreement each party must return to the other any property of the other
party that it has in its possession or control. Evotec must without undue delay and no later than 60 (sixty) business days after the termination notice or expiry of the Agreement provide Novo Nordisk with all data created until the date of
termination: 

  

	 	a)	 Evotec should adhere to industry best practice for data deletion methods, for example, NIST SP 800-88. 

  

	 	b)	 Within 3 months from project completion, Evotec must provide Novo Nordisk at Novo Nordisk’s expenses with
a copy of all data owned by Novo Nordisk upon request. Data will be delivered by secure means in a commonly used industry standard format. Costs for the data extraction, packaging and sending shall be mutually agreed as part of the contact
definition. 

  

	12.	 Human Biosamples and Animal Welfare. 

 

	12.1	 In regard of the collection, storage, handling and use of human biosamples hereunder, the Parties represent and
warrant to use best efforts to adhere to and comply with their respective obligations and undertakings set forth in APPENDIX 2 hereto. The Parties understand that APPENDIX 2 is an integral part of this Agreement. 

  
 page 18 of 22 

	12.2	 The Parties agree to ensure high welfare standards for experimental animals. Evotec acknowledges that it has
read and understood the Novo Nordisk Principles for the Use of Animals attached hereto as 0 and agrees to adhere to and comply with these obligations. Evotec must promptly notify Novo Nordisk in the event of any unexpected issues in relation to
animal welfare or bioethical concerns that occur in the Project and during the Term. The Parties agree to collaborate to address any such issues and concerns. 

 

	12.3	 Novo Nordisk i) will review the Project and the protocol(s) and ii) may require an on-site animal welfare inspection prior to approval of the particular Project. If Novo Nordisk wishes to perform an animal welfare inspection prior to or during the Term, Evotec grants Novo Nordisk, upon 30 days
prior written notice, the right to audit, in a manner minimally disruptive to Evotec’s operations, Evotec’s compliance with applicable animal welfare law. Novo Nordisk’s representatives conducting such audit shall be bound by terms
and conditions that are at least equivalent to those of this Agreement. 

  

	13.	 No Consequential Damages, Liability, and Indemnification 

 

	13.1	 No Consequential Damages. Neither Party shall be liable to the other Party for any consequential,
special, incidental or indirect damages or lost profits arising out of the activities contemplated hereunder or resulting from breach by the other Party of its obligations under this Agreement, even if a Party has been advised of the possibility of
such damages. 

  

	13.2	 Evotec shall have no liability whatsoever to Novo Nordisk or any designee whether in contract or tort, for any
loss or damage arising out of any development, exploitation, use or other activity by Novo Nordisk relating to the deliverables provided by Evotec hereunder on behalf of Novo Nordisk or any designee, or its/their respective licensees, transferees or
assignees, unless due to the negligence or willful misconduct of Evotec. 

 Evotec’s total liability to Novo Nordisk
in respect of any matters arising out of or in connection with a breach of Section 6 or of any other matters arising out of or in connection with this Agreement shall not exceed (i) where a matter relates to or is under a specific Project,
one time (1x) all fees paid by Novo Nordisk to Evotec under such Project, or (ii) where a matter does not relate to or is under a Project, one (1) million Euros.. 
  

	13.3	 Section 13.2 shall not operate to include or limit any liability which Evotec is prohibited by law from
excluding or limiting, including liability for death or personal injury caused by the negligence of Evotec. 

  

	13.4	 Evotec shall fully indemnify, and keep fully indemnified, Novo Nordisk’s officers, directors, governing
board members, professional staff, employees, and agents and their respective successors and assigns (the “Novo Nordisk Indemnitees”) against any and all claims, liabilities, damages, losses, costs or expenses (including reasonable legal
expenses and experts’ fees) incurred by or imposed on Novo Nordisk Indemnitees or any one or more of them arising out of any Third Party claim, action, demand or judgment (“Claim”) to the extent resulting from (i) Evotec’s
gross negligence or willful misconduct, or (ii) Evotec’s material breach of this Agreement. 

  

	13.5	 Novo Nordisk shall fully indemnify, and keep fully indemnified, Evotec’s officers, directors, governing
board members, professional staff, employees, and agents and their respective successors and assigns (the “Evotec Indemnitees”) against any and all claims, liabilities, damages, losses, costs or expenses (including reasonable legal
expenses and experts’ fees) incurred by or imposed on the Evotec Indemnitees or any one or more of them arising out of any Third Party claim, action, demand or judgment (“Claim”) to the extent resulting from (i)

  
 page 19 of 22 

	 	
Novo Nordisk’s negligence or willful misconduct; (ii) Novo Nordisk’s breach of this Agreement; (iii) Novo Nordisk’s (or any designee’s) use of the Project IP; or
(iv) Evotec’s use of any information or other deliverable of the Novo Nordisk (including Novo Nordisk Materials or Novo Nordisk Background IP) for the purpose of performing the Drug Discovery & Development Services, but only to
the extent such claim does not result from, or arise out of, an action for which Evotec is obligated to indemnify Novo Nordisk pursuant to Section 13.4.     

 

	14.	 Miscellaneous 

 

	14.1	 Force Majeure. Neither Party shall have any liability or be deemed to be in breach of this Agreement for
any delays or failures in performance of this Agreement which result from circumstances beyond the reasonable control of that Party, including without limitation labour disputes, natural disasters, or any other force majeure event, involving that
Party. The Party affected by such circumstances shall promptly notify the other Party in writing when such circumstances cause a delay or failure in performance and when they cease to do so. If the Parties are affected by such circumstances for
ninety (90) or more days, either Party may terminate a Project or this Agreement without fault. 

  

	14.2	 Assignment. Neither Party may assign its obligations under this Agreement without the prior written
consent of the other Party. However, both Parties may, without such consent assign this Agreement, and its rights and obligations hereunder, to any successor in interest (whether by merger, acquisition, consolidation, operation of law, asset
purchase or otherwise) to all or substantially all of the business to which this Agreement relates (such transaction called a “Change of Control”). Notwithstanding the foregoing, Both Parties may assign its rights to any of its Affiliates.

  

	14.3	 Entire Drug Discovery & Development Services Agreement; Amendment. This Agreement
constitutes the entire agreement between the Parties relating to the Services and all prior understandings and agreements relating to the Services are superseded hereby from the Effective Date. The Parties acknowledge that they are not relying on
any agreement, understanding, arrangement, warranty, representation or term which is not set out in this Agreement. 

This Drug Discovery & Development Services Agreement (including this Section 13) and the attached Appendices may not be amended
except by mutual agreement by the Parties herein as expressed in writing signed by authorized representatives of the Parties. 
 For the
avoidance of doubt, no Project Description, invoice or any other document shall be deemed to vary the terms of this Agreement or any Appendix, unless explicitly stated otherwise and confirmed by authorized representatives of the Parties. 

 

	14.4	 No Waiver. Any failure of a Party to enforce any provision of this Agreement shall not be deemed a
waiver of its right to enforce such provision on any subsequent occasion. No waiver of any provision of this Agreement shall be valid unless it is in writing and is executed by the Party against which such waiver is sought to be enforced. A waiver
by any of the Parties of any provision of this Agreement will not be construed to be a waiver of any succeeding breach thereof or of any other provision of this Agreement. 

 

	14.5	 Severability. Whenever possible, each provision of this Agreement shall be interpreted in such manner as
to be effective and valid under applicable law. In the event a court of competent jurisdiction holds any provision of this Agreement to be invalid, such holding shall have no effect on the remaining provisions of this Agreement, and they shall
continue in full force and effect. 

  
 page 20 of 22 

	14.6	 Governing Law. The laws of Denmark (without giving effect to its conflict of laws principles) govern all
matters arising out of or relating to this Agreement (including, without limitation, its interpretation, construction, performance, and enforcement). 

14.7 Dispute Resolution. The Parties shall attempt in good faith to resolve promptly any dispute arising out of or relating to this
Agreement by negotiation between executives who have authority to settle the dispute. The executives must be at a higher level of management than the persons with direct responsibility for administration of this Agreement. Thereafter, any
disagreements that prevail for more than thirty (30) days should be settled by arbitration. 
  

	14.8	 Sub-Contracting. With respect to each Project, if Evotec desires
to sub-contract Services to a Third Party sub-contractor (each sub-contractor a “ Services
Sub-Contractor”), Novo Nordisk shall have the right to approve the use of such Services Sub-Contractor. For the avoidance of any doubts, Evotec’s
Affiliates shall not be deemed as Services Sub-Contractors. Evotec may sub-contract Services to its Affiliate(s) without obtaining prior written approval of Novo
Nordisk. Evotec hereby agrees that each Services Sub-Contractor and its Affiliates shall agree in writing to conduct such sub-contracted Services in accordance with, and
subject to, terms and conditions equivalent to those of this Agreement. Evotec hereby further agrees that Evotec shall be solely responsible and liable for the Services conducted by each Services
Sub-Contractor or Affiliate as if such Services were conducted by Evotec. 

  

	14.9	 Independent Contractors. It is expressly agreed that Evotec and Novo Nordisk will be independent
contractors and that the relationship between the parties will not constitute a partnership or agency of any kind. Neither Evotec nor Novo Nordisk will have the authority to make any statements, representations or commitments of any kind, or to take
any action, which will be binding for the other Party, without the prior written consent of the other Party. 

  

	14.10	 Notices. All notices and other communications provided for under this Agreement will be in English in
writing sent as PDF via e-mail in advance. Originals are sent without undue delay by airmail as a default unless overnight delivery service is requested, and in each case will be addressed to the parties at
the following addresses: 

  

							
		  	For Evotec:	  	For Novo Nordisk:	  	
				
		  	Evotec International GmbH	  	Novo Nordisk A/S	  	
	        	  	Attn. Legal Department	  	Novo Alle	  	
		  	Manfred Eigen Campus	  	2880 Bagsvaerd, Denmark	  	
		  	Essener Bogen 7	  	Attn: Head of Business Development	  	
		  	22419 Hamburg, Germany	  	copy: Legal Dept	  	
		  	Fax:  + 49-40-56081-222	  	Fax:    +45- 4442 1830	  	

  

	14.11	 Counterparts. This Agreement may be executed in two (2) or more counterparts, each of which will be
deemed an original, but all of which together will constitute one and the same instrument. Counterparts may be signed and delivered by facsimile, each of which will be binding when sent, and in each case an original will be sent via overnight
courier. 

 [signature page follows] 

  
 page 21 of 22 

 IN WITNESS WHEREOF, Evotec and Novo Nordisk have executed this Agreement by duly authorized representatives
as of the Effective Date. 
  

					
	Novo Nordisk A/S	 		 	Evotec International GmbH
			
	By: [***]	 		 	By: [***]
	Title: SVP Global Drug Disc.	 		 	Title: EVP Legal
			
	By: [***]	 		 	By: [***]
	Title: EVP Project Manegement	 		 	Title: SVP Group Accounting

  
 page 22 of 22EX-10.13

 Exhibit 10.13 

 

			
	EXECUTION VERSION	  	8 July 2020

 THE SYMBOL “[***]” DENOTES PLACES WHERE CERTAIN IDENTIFIED 

INFORMATION HAS BEEN EXCLUDED FROM THE EXHIBIT BECAUSE IT IS BOTH (i)

NOT MATERIAL, AND (ii) WOULD LIKELY CAUSE COMPETITIVE HARM TO THE 

COMPANY IF PUBLICLY DISCLOSED 

RESEARCH COLLABORATION AND LICENSE AGREEMENT 

by and between 
 Novo
Nordisk A/S 
 and 

Evotec International GmbH 

			
	EXECUTION VERSION	  	8 July 2020

  

 Table of Contents 

 

							
	 Section 1.
	  	 DEFINITIONS AND INTERPRETATION
	  	 	4	 
	 Section 2.
	  	 PURPOSE OF THE COLLABORATION
	  	 	14	 
	 Section 3.
	  	 GENERAL PROVISIONS
	  	 	15	 
	 Section 4.
	  	 PHASES OF THE COLLABORATION
	  	 	16	 
	 Section 5.
	  	 EXCLUSIVITY
	  	 	17	 
	 Section 6.
	  	 GOVERNANCE
	  	 	19	 
	 Section 7.
	  	 TECHNICAL INFORMATION, INFORMATION EXCHANGE, MATERIALS
	  	 	24	 
	 Section 8.
	  	 RECORDS AND REPORTS
	  	 	25	 
	 Section 9.
	  	 OWNERSHIP AND IP
	  	 	26	 
	 Section 10.
	  	 LICENSES
	  	 	29	 
	 Section 11.
	  	 FURTHER DEVELOPMENT AND COMMERCIALIZATION OF PRODUCTS
	  	 	30	 
	 Section 12.
	  	 MANUFACTURE AND SUPPLY, REGULATORY MATTERS
	  	 	30	 
	 Section 13.
	  	 COMPLIANCE
	  	 	31	 
	 Section 14.
	  	 CONSIDERATION
	  	 	31	 
	 Section 15.
	  	 PAYMENT AND TAXES
	  	 	36	 
	 Section 16.
	  	 RECORDS AND AUDIT
	  	 	38	 
	 Section 17.
	  	 CONFIDENTIALITY AND PUBLICATION
	  	 	39	 
	 Section 18.
	  	 REPRESENTATIONS AND WARRANTIES; LIMITATION OF LIABILITY
	  	 	41	 
	 Section 19.
	  	 INDEMNIFICATION
	  	 	43	 
	 Section 20.
	  	 TERM AND TERMINATION
	  	 	45	 
	 Section 21.
	  	 EFFECTS OF TERMINATION
	  	 	46	 
	 Section 22.
	  	 MISCELLANEOUS
	  	 	52	 

 Annexes 
 - Annex A –
Research Plan 
 - Annex B – Novo Nordisk Principles on the Use of Animals 

- Annex C – Human Biosamples and Personal Data 
 - Annex D
– Novo Nordisk Invoicing Principles 

			
	EXECUTION VERSION	  	8 July 2020

  

 RESEARCH COLLABORATION AND LICENSE AGREEMENT 

 

			
	between            	  	Novo Nordisk A/S
		
		  	Novo Allé
		
		  	2880 Bagsværd
		
		  	Denmark
		
		  	hereinafter referred to as “Novo”
		
	and	  	Evotec International GmbH
		
		  	Manfred Eigen Campus
		
		  	Essener Bogen 7
		
		  	22419 Hamburg
		
		  	Germany
		
		  	hereinafter referred to as “Evotec”
		
		  	Novo and Evotec hereinafter individually referred to as “Party” and collectively as “Parties”

 WHEREAS, Novo is a global research-based pharmaceutical company which, inter alia, is engaged in the research,
development and commercialization of pharmaceutical products; 
 WHEREAS, Evotec is a research-based pharmaceutical company which, inter alia, is
engaged in the research and development of compounds in the area of treatment of kidney diseases; 
 WHEREAS, Evotec has worked on the identification and
validation of biological targets as well as development of compounds, and assays to identify compounds that may have the potential to treat, inter alia, (chronic) kidney diseases; 

  
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 WHEREAS, Evotec is an industry partner of, has access to, and performs data mining and drug discovery based
on, the unique kidney disease patient cohorts and data collected by the NURTuRE Consortium (as defined below). In addition, Evotec has access to the epidemiological, laboratory, and tissue datasets of patients with kidney disease as collected and
generated under the Salford Kidney Study (SKS); 
 WHEREAS, the Parties wish to collaborate to identify and validate target candidate options arising out of
the NURTuRE Consortium and the SKS and to initiate drug discovery programs on selected targets; 
 NOW, THEREFORE, in consideration of the mutual covenants
contained in this Agreement, Novo and Evotec hereby agree as follows: 
  

	1.	 DEFINITIONS AND INTERPRETATION 

 

	A.	 Definitions 

As used in this Agreement the following terms shall have the meaning indicated: 
  

	1.1	 “Affiliate” shall mean, with respect to a Party, any person, corporation, firm,
joint venture or other entity which, directly or indirectly, through one or more intermediates, controls, is controlled by or is under common control with such Party. As used in this definition, “control” means possession of the power to
direct or cause the direction of the management and policies of an entity, whether through the ownership of the outstanding voting securities or by contract or otherwise. For purposes of this definition, Novo Holdings A/S, the Novo Nordisk
Foundation and their respective affiliates (other than Novo and its subsidiaries) shall not be considered Affiliates of Novo. 

  

	1.2	 “Agreement” shall mean this Research Collaboration and License Agreement including its
Annexes. 

  

	1.3	 “Applicable Laws” shall mean the laws, rules, and regulations, including any statutes,
guidelines, or other requirements as may be in effect and changed from time to time and apply to the research activities, development, manufacture, registration, and Commercialization of a Product in the Territory, and any other applicable statutes,
rules, regulations, guidelines, or other requirements of the relevant Regulatory Authority. 

  

	1.4	 “Background IP” shall mean all information (including without limitation, processes, methods,
techniques, designs, structures, applications, software, and specifications) that is owned, Controlled, licensed, developed, or acquired solely outside the performance of this Agreement by a Party or on behalf of that Party by an Affiliate or a
Third Party. Background IP of a Party shall include Improvements of such Background IP. 

  

	1.5	 “Back-up PDC” shall mean any Compound that (i) is
of the same structural class as a PDC, (ii) was not initially selected by Novo as a PDC in a Project and (iii) is intended by Novo to potentially replace the PDC in further development, or to be brought into development in addition
thereto. 

  
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	1.6	 “Business Day” shall mean any day that is not a Saturday, Sunday, bank holiday or public
holiday in the Federal Republic of Germany or in the Kingdom of Denmark. 

  

	1.7	 “Calendar Quarter” shall mean each of the three (3) month’
periods ending on each of March 31, June 30, September 30 and December 31.  

  

	1.8	 “Candidate Target” shall mean a disease-modifying biological target (such as a human protein)
to which a drug for the diagnosis, prevention and/or treatment within the Target Field can bind, which target has been submitted to the JSC for a decision on inclusion in the Target Pool. For clarity, Candidate Targets and their use in the Target
Field shall be considered the Confidential Information of the Party that has first proposed such Candidate Target to the other Party. 

  

	1.9	 “Collaboration Activities” shall mean the Parties’
pre-clinical research activities under the Research Plan and Project Plan(s), aiming at identifying and optimizing Compounds, including reagent development, assay development, screening, profiling, structural
biology activities, medical chemistry activities, computational chemistry activities, in-vitro and in-vivo testing. 

 

	1.10	 “Collaboration Term” shall mean the term of the Collaboration Activities as defined in
Section 20.1. 

  

	1.11	 “Combination Product” shall mean a Product sold in combination with any other active
pharmaceutical ingredient or in a device, in any dosage form and/or co-formulation and/or co-packaging based on combination of such Product with any other active
pharmaceutical ingredient or any device. 

  

	1.12	 “Commercialization” or “Commercialize” shall mean all activities undertaken relating
to the manufacture, pre-marketing, marketing, promoting, distributing, offering for sale and selling of a Product, whether before or after Regulatory Approval has been obtained. 

 

	1.13	 “Commercially Reasonable Efforts” shall mean the level of efforts and
resources, including financial resources, comparable to those normally used by a reasonable Third Party pharmaceutical company to exert the effort to conduct the relevant activity, including, in the case of research, development, manufacture or
Commercialization, the level of effort and resources comparable to those normally used by such Third Party for a product which is of similar market potential and at a similar stage in its development or product life, taking into account efficacy,
profitability and commercial potential, pricing and reimbursement policies, competitiveness of other products and product candidates in research, development, and Commercialization (including the development of other similar internal Novo product
candidates), the specific scope, subject matter, coverage, and duration of (potential) Patent Right protection, and other relevant factors. Notwithstanding the foregoing, the Parties also acknowledge that Novo (and its Affiliates) do not always seek
to market its products in every country or seek to obtain Regulatory Approval in every country or for every potential indication. As a result, the exercise by Novo of Commercially Reasonable Efforts will be determined by judging its performance
taken as a whole.  

  
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	1.14	 “Compound” shall mean (a) any Small Molecule Compound; and (b) any antibody (whether
fully human, humanized, phage display-derived, chimeric, polyclonal, or any other type of antibody including fragments thereof); (c) any therapeutic protein, protein fusion, fragment, peptide, or protein/peptide conjugate; (d) any nucleic acid
based agent such as aptamers, agents working via RNAi, antisense; and (e) any other molecular entity, which, in each case ((a), (b), (c), (d) and (e) above), (i) modulates the activity of a Target to produce the desired biological effect
as described in each individual Project Plan and (ii) is synthesized by either Party within the Collaboration Activities. 

For clarity, “Compound” does not include the Evotec Library Compounds or any compounds that are in existence and Controlled by Novo
at the Effective Date or are developed by or Controlled by Novo after the Effective Date outside the collaboration under this Agreement. 
  

	1.15	 “Compound Data” shall mean the data regarding Compounds generated by or
on behalf of a Party within the Collaboration Activities, including but not limited to any and all data regarding biological, chemical, pharmacological, toxicological, pharmacokinetic, analytical, quality control and other data and descriptions.

  

	1.16	 “Compound Patent” shall mean a Patent Right on a Compound, including the manufacture thereof
(including but not limited to synthesis and purification) and the method for modulating the Target and/or for modulating the activity of the Target, which Patent Right results from patent applications arising under the Collaboration Activities.

  

	1.17	 “Confidential Information” shall mean (i) the terms of this Agreement including all
Annexes and (ii) with respect to any Party (“Disclosing Party”), any information relating to the Disclosing Party or the Disclosing Party’s business (including but not limited to
Know-How, technical information, research, personnel, marketing, strategic or other information) and other information which is disclosed in writing, visually, orally or in electronic medium to the other Party
(“Receiving Party”), whether prior to or after the Effective Date, in the course of the Parties’ evaluation, negotiation of or performance under this Agreement. “Confidential Information” shall not include information
which: 

  

	 	(a)	 was previously known to the Receiving Party or any of its Affiliates prior to disclosure by the Disclosing
Party under this Agreement, as shown by written evidence, and was not obtained or derived directly or indirectly from the Disclosing Party, or 

  

	 	(b)	 was or has become public or available through no act or default of the Receiving Party or any of its
Affiliates, or 

  
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	 	(c)	 was independently developed by the Receiving Party or any of its Affiliates without the use or reliance on any
Confidential Information provided by the Disclosing Party hereunder as shown by appropriate evidence, or 

  

	 	(d)	 was obtained by the Receiving Party or any of its Affiliates from a Third Party who was lawfully in possession
of such information or data and was not subject to an obligation of confidentiality or non-use owed to the Disclosing Party or others. 

 

	1.18	 “Control” or “Controlled” shall mean with respect to any Intellectual
Property Right, that the Party controlling such right owns a transferable interest or has a license to practice such Intellectual Property Right and has the ability to grant the other Party access, a license or a sublicense (as applicable) to
practice such Intellectual Property Right. 

  

	1.19	 “Cover”, “Covering” or “Covered by” shall mean (a) with
respect to Know-How, that such Know-How was used in the exploitation of the Product, and (b) with respect to a Patent Right, that the making, using or selling of
the Product would, absent a license to or ownership of such Patent Right, constitute an infringement of a Valid Claim. 

  

	1.20	 “Data” shall mean the data generated by or on behalf of a Party or the Parties within the
Collaboration Activities, including but not limited to Target Data and Compound Data. 

  

	1.21	 “Effective Date” shall mean 01 August 2020. 

 

	1.22	 “EMA” shall mean the European Medicines Agency and associated committees and decision bodies,
or any successor agency thereto. 

  

	1.23	 “Evotec Background IP” shall mean Background IP owned or Controlled by Evotec as applied in
connection with the Collaboration Activities, including, without limitation, Evotec Background Know-How, Evotec Background Patents, the Evotec Library and the Evotec Library Compounds; as well as any
Improvements thereto. 

  

	1.24	 “Evotec Background Know-How” shall mean any Know-How as applied in connection with the Collaboration Activities (a) which is in existence and Controlled by Evotec at the Effective Date or coming into the Control of Evotec by way of acquisition or license
after the Effective Date and (b) which is developed and Controlled by Evotec after the Effective Date and not in connection with the Collaboration Activities. 

 

	1.25	 “Evotec Background Patent(s)” shall mean any Patent Rights as applied in connection with the
Collaboration Activities (a) which are in existence and Controlled by Evotec at the Effective Date or coming into the Control of Evotec by way of acquisition or license after the Effective Date or (b) which Cover inventions developed and
Controlled by Evotec after the Effective Date independently of the Collaboration Activities. For clarity, “Evotec Background Patents” does not comprise of Compound Patents. 

  
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	1.26	 “Evotec Library” shall mean the chemical entity library prepared by or on behalf of Evotec or
its Affiliates, screened under or in connection with the Collaboration Activities. 

  

	1.27	 “Evotec Library Compounds” shall mean the compounds in the Evotec Library.

  

	1.28	 “FDA” shall mean the US Food and Drug Administration and associated committees and decision
bodies, or any successor agency thereto. 

  

	1.29	 “First Commercial Sale” shall mean with respect to a Product, on a country-by-country basis, the first commercial transfer or disposition for value of such Product for end use in such country to a Third Party (not being a Sublicensee for the
relevant Product) by Novo or any of its Affiliates or Sublicensees after the Regulatory Authority, having jurisdiction for such country, has granted Regulatory Approval for such Product. The following sales shall not constitute a First Commercial
Sale: (i) sales for clinical studies, compassionate use, named patient programs, or any similar instance where the Product is sold at cost or supplied without charge such as clinical supplies, free samples (promotional or otherwise) or as
donations (for example to non-profit institutions or government agencies for a non-commercial purpose) as well as (ii) sales between Novo and/or its Affiliates
and/or Sublicensees for later resale by the recipient or later use for the excluded purposes in (i), which do not constitute a commercial launch of the Product in the market. 

 

	1.30	 “FTE” shall mean with respect to either Party the equivalent of one individual employed by
that Party having the requisite skills to fulfil that Party’s obligations under this Agreement and devoting the equivalent hours of a full time employee. For the purpose of this Agreement, “full time” shall mean 1,650 hours per year
as determined in accordance with each Party’s regular project reporting system. 

  

	1.31	 “Hit” shall mean an Evotec Library Compound that shows relevant affinity towards a Target. For
clarity, “Hits” are not considered “Compounds” under this Agreement. 

  

	1.32	 “Improvements” shall mean any and all improvements and/or further developments, whether
patentable or not, of Background IP that: (i) are conceived and reduced to practice as part of, and/or that otherwise are made as part of and/or arise out of, the Collaboration Activities; and that (ii) are not Project IP.

  

	1.33	 “IND” shall mean any clinical trial application, including any Investigational New Drug
Application filed or to be filed with the FDA pursuant to 21 CFR 312.1 et seq., as such regulations may be amended from time to time, and any equivalent application in jurisdictions outside the US. 

 

	1.34	 “Intellectual Property Rights / IPR” shall mean Patent Rights and Know-How. 

  

	1.35	 “Joint Project Team” or “JPT” shall have the meaning set forth in Section 6.4.

  

	1.36	 “Joint Research Team” or “JRT” shall have the meaning set forth in Section 6.2.

  
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	1.37	 “Joint Steering Committee” or “JSC” shall have the meaning set forth in
Section 6.5. 

  

	1.38	 “JPT Manager” shall have the meaning set forth in Section 6.4.2. 

 

	1.39	 “Know-How” shall mean any scientific or technical
information, data (including but not limited to the Data) and results of any type whatsoever, in any tangible or intangible form whatsoever, that is not in the public domain or otherwise publicly known, including databases, practices, methods,
techniques, specifications, formulations, formulae, knowledge, skill, experience, test data including pharmacological, medicinal chemistry, biological, chemical, biochemical, toxicological and clinical test data, analytical and quality control data,
stability data, studies and procedures, and manufacturing process and development information, results and data, that are not in the public domain or otherwise available to the public, including inventions before patent application; all to the
extent not claimed or disclosed in a Patent Right. 

  

	1.40	 “Material” shall mean any tangible material, which is required for or used under the
Collaboration Activities, including (a) chemical compounds (reference compounds, precursor and metabolite), (b) gene modified animals, (c) biological material from animals or human, (d) cell lines; (e) post mortem human
tissue. 

  

	1.41	 “NDA” shall mean a New Drug Application filed as a result of activities under this Agreement
with the FDA, or the equivalent application to the equivalent Regulatory Authority in any other country of the Territory, the filing of which is necessary to Commercialize a Product, including all amendments and supplements to any of the
foregoing.  

  

	1.42	 “Net Sales” shall mean all revenues, recognized in accordance with IFRS
applied on a consistent basis, from the sale of Product by Novo or its Affiliates or its Sublicensees to Third Parties (including wholesalers and distributors) in arm’s length transactions exclusively for money or, where the sale is not at
arm’s length or not exclusively for money, the price that would have been so invoiced if it had been at arm’s length exclusively for money, less the following deductions: 

 

	 	•	 	 1% of the gross amount as a flat rate for transportation, freight insurance, distribution, packing and handling;

  

	 	•	 	 sales and excise taxes or customs duties paid by Novo, its Affiliates or Sublicensees or any other governmental
charges imposed upon the sale of Products and paid by Novo, its Affiliates or Sublicensees; 

  

	 	•	 	 rebates and premiums granted or allowed by Novo, its Affiliates or Sublicensees in connection with the sale of
Products; 

  

	 	•	 	 allowances or credits granted by Novo, its Affiliates or Sublicensees to customers on account of governmental
requirements, rejection, outdating, returns, price adjustments, billing errors or recalls of Products; 

  
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	 	•	 	 trade, cash and quantity discounts, allowances, bonuses, credits or chargebacks granted by Novo, its Affiliates
or Sublicensees in connection with the sale of Products; 

  

	 	•	 	 costs of customer programs agreed upon by the Parties such as cost effectiveness or patient assistance studies or
programs designed to aid in patient compliance with medication schedules in connection with the sales of Products; 

  

	 	•	 	 1% of the gross amount as a flat rate for bad debts; and 

 

	 	•	 	 any item substantially similar in character and / or substance to the above. 

Net Sales shall not include sales by Novo to Affiliates or to Sublicensees engaged by or partnered with Novo to develop, promote, co-promote, market or sell Product, solely to the extent that such Affiliate or Sublicensee purchasing the Product intends to resell such Product to a Third Party. However, subsequent sales of Product by such
Novo’s Affiliates or Sublicensees to a Third Party shall be included in the Net Sales when sold in the market. 
 In the event a Product
is sold in the form of a Combination Product, the Net Sales for such Combination Product will be determined by multiplying actual the Net Sales of such Combination Product by the fraction A / (A+B) where A is the average unit selling price of the
Product in the same dosage amount or quantities sold separately in that country in the relevant Calendar Quarter and B is the total average unit selling price of the device or second pharmaceutical product in the same dosage amount or quantities
when sold separately in that country in the relevant Calendar Quarter. If, on a country-by-country basis, the second pharmaceutical product or device is not sold
separately in a country, the Net Sales for that country shall be calculated by multiplying the actual Net Sales for such Combination Product by the fraction A / C where A is the invoice price of the Product, if sold separately, and C is the invoice
price of the Combination Product. If, on a country-by-country basis, neither the Product nor the second pharmaceutical product or device are sold separately in a
country, then, to determine the Net Sales in such country, the fair market value of the Product and the second pharmaceutical product or device shall be determined between the Parties in good faith for the relevant transactions based on an equitable
method of determining the same that takes into account, in the Territory, variations in potency, the relative contribution of each therapeutically active ingredient, and relative value to the end user of each therapeutically active ingredient. 

Novo calculates and reports Net Sales in Danish Kroner (DKK). With respect to Net Sales invoiced in a currency other than DKK such amounts and
amounts payable will be expressed in such currency and converted to DKK using the exchange rate mechanism mentioned in Section 15.1. 

  
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	1.43	 “Novo Background IP” shall mean Background IP owned or Controlled by Novo as applied in
connection with the Collaboration Activities, including, without limitation, the Novo Background Know-How and the Novo Background Patents; as well as any Improvements thereto. 

 

	1.44	 “Novo Background Know-How” shall mean any Know-How applied in connection with the Collaboration Activities which is in existence and Controlled by Novo at the Effective Date or is developed or Controlled by Novo after the Effective Date outside of the
Collaboration Activities. 

  

	1.45	 “Novo Background Patent(s)” shall mean any Patent Right(s) as applied in connection with the
Collaboration Activities which are in existence and Controlled by Novo at the Effective Date or which Cover inventions developed or Controlled by Novo outside of the Collaboration Activities. For clarity, “Novo Background Patents” does not
comprise of Compound Patents. 

  

	1.46	 “Novo Post-Collaboration IPR” shall mean, collectively, any Intellectual Property Rights in
respect of a Compound, which are conceived or originated by or on behalf of Novo following the expiration or termination of a Project or the Agreement, regardless of whether the Project for the relevant Compound was abandoned or not.

  

	1.47	 “NURTuRE Consortium” shall mean the National Unified Renal Translational Research Enterprise
consortium, consisting of UK-based academic institutions and industry partners, with a focus on CKD and nephrotic syndrome patients and with access to NURTuRE biobank (“NURTuRE Biobank”)
consisting of kidney patient derived samples and data sets to characterise human pathology with detailed histological and molecular analysis.  

  

	1.48	 “Patent Rights” shall mean the rights and interests in and to (a) all national, regional
and international patents, utility models and pending applications with respect to patents and utility models filed in any country or jurisdiction of the world including provisional patent applications, (b) all patent applications filed (before
the Effective Date or thereafter) either from such patents, patent applications or provisional applications or from an application claiming priority from either of these, including any continuation, continuation-in-part, divisional, provisional, converted provisionals and continued prosecution applications, or any substitute applications, (c) any patent issued (at the Effective Date or thereafter)
with respect to or in the future issued from any such patent applications including utility models, petty patents and design patents and certificates of invention, (d) any and all extensions or restorations by existing or future extension or
restoration mechanisms, including revalidations, reissues, re-examinations and extensions and any supplementary protection certificates (and the like) of the foregoing patents or patent applications,
(e) any similar rights, or any importation, revalidation, confirmation or introduction patent or registration patent or patent of additions to any such foregoing patent applications and patents and all foreign counterparts of any of the
foregoing. 

  
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	1.49	 “PDC / Preclinical Development Candidate” shall mean a Compound that is approved by Novo under
Section 4.2 for initiation of further preclinical and clinical development activities; or any derived analogue thereof. For clarity, once Novo has submitted an IND, a PDC shall no longer be deemed a “PDC” but shall be deemed a
“Product” under this Agreement. 

  

	1.50	 “Phase I Clinical Trial” shall mean, in accordance with the ICH Harmonized Tripartite
Guideline ”General Considerations for Clinical Trials E-8”, as amended, the initial administration of a Product in humans for investigation of (a) initial safety and tolerability;
(b) pharmacokinetics (absorption, distribution, metabolism, and excretion) (c) pharmacodynamics (usual PK/PD studies relating drug blood levels to response) and (d) early measurements of the drug activity in healthy volunteers or
patients. 

  

	1.51	 “Phase II Clinical Trial” and “Phase III Clinical Trial” shall have the
meaning described in the ICH Harmonized Tripartite Guideline entitled “General Considerations for Clinical Trials”, as amended.  

  

	1.52	 “PMDA” shall mean the Pharmaceuticals and Medical Devices Agency in Japan and associated
committees and decision bodies, or any successor agency thereto. 

  

	1.53	 “Product” shall mean any pharmaceutical composition that includes or consists of one or more
PDCs or one or more Back-up PDCs. 

  

	1.54	 “Project” shall mean the Collaboration Activities, set out in the corresponding Project Plan,
to be performed by the Parties on a particular Project Target up until Novo’s PDC decision of the relevant Compound under Section 4.2. 

  

	1.55	 “Project IPR” shall mean all inventions made by a Party within the Collaboration Activities
that do not relate to Compounds and are not considered Compound Patents. 

  

	1.56	 “Project Plan” shall mean a plan setting forth the details for a Project, including minimum
objectives, the Project Target, the Collaboration Activities to be performed by each Party, the deliverables, timelines and further specifics. A basic outline for a Project Plan is included in the Research Plan (Annex A). 

 

	1.57	 “Project Target” shall mean a Target that has been designated by the JSC in accordance with
Section 6.5.1 to become subject of a Project. 

  

	1.58	 “Regulatory Approval” shall mean any marketing and pricing and reimbursement approval,
including any registration or authorization, from any Regulatory Authority required to develop, manufacture, market and sell a Product in a jurisdiction. 

  

	1.59	 “Regulatory Authority” shall mean any country, federal, supranational, state or local
regulatory agency, court, department, bureau, commission, council or other governmental or regulatory authority of any government or country or of any national, federal, state, provincial, regional, county, city or other political subdivision of any
such government or any supranational organization of which any such country is a member, having the administrative authority to regulate the development of compounds or commercialization pharmaceutical products in any country or other jurisdiction
including the FDA and EMA and any other successor to them, or with respect to approval of pricing or reimbursement for such product. 

  
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	1.60	 “Research Plan” shall mean the research plan including the overall objectives for the
Collaboration Activities up to a Project, the overall deliverables, general timelines, the general distribution of FTE support and further specifics. The Research Plan will be updated from time to time by the JRT in accordance with Section 6.2.

  

	1.61	 “Royalty Term” shall mean the duration of royalty payments as defined in Section 14.4.2.

  

	1.62	 “Section” shall mean a section of this Agreement. 

 

	1.63	 “Small Molecule Compound” shall mean any organic,
non-peptidic (meaning with maximum four amino acids) Compound with a molecular weight below 800 Daltons, including any salt, amorphous, crystalline, solvate, ester, ether, and/or stereo-isomeric variation
thereof, for which Evotec has conducted the drug discovery efforts under the Collaboration Activities as per the JSC’s decision. 

  

	1.64	 “Sublicensee” shall mean, with respect to a Party, any person, company, corporation or other
business entity, other than a Party’s Affiliate, that is granted a sublicense by such Party under this Agreement. For clarity, wholesalers and distributors of Novo and/or its Affiliates are not considered ‘Sublicensees’ under this
Agreement. 

  

	1.65	 “Target” shall mean a target that, by decision of the JSC, has been included in the Target
Pool. 

  

	1.66	 “Target Data” shall mean the data regarding a target (including but not limited to targets on
the Mining List, Candidate Targets proposed by Evotec, Targets and Project Targets) generated by a Party or the Parties within the Collaboration Activities, including the fact that there is a Hit. Data regarding a Candidate Target proposed by Novo
shall not be considered “Target Data” hereunder. 

  

	1.67	 “Target Field” shall mean the diagnosis, prevention and/or treatment of Chronic Kidney Disease
(CKD).  

  

	1.68	 “Target Pool” shall have the meaning set forth in Section 4.1. 

 

	1.69	 “Territory” shall mean worldwide. 

 

	1.70	 “Third Party” shall mean any entity other than Novo or Evotec or their respective Affiliates.

  

	1.71	 “Trademark” shall mean any trademark for use in connection with the Commercialisation of a
Product in the Territory. 

  
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	1.72	 “Valid Claim” shall mean with respect to any country of the Territory either: (a) a claim
of an issued and unexpired Patent Right, which (i) has not been held unenforceable, unpatentable or invalid by a decision of a court or other governmental agency of competent jurisdiction, unappealable or unappealed within the time allowed for
appeal, (ii) has not been admitted to be invalid or unenforceable through reissue or disclaimer or otherwise and (iii), absent a license, would be infringed by the making, selling, import or use of a Product; or (b) a claim included in a
pending patent application that is being prosecuted in good faith and that has not been cancelled, withdrawn from consideration, finally determined to be unallowable by the applicable governmental authority (from which no appeal is or can be taken),
or abandoned or disclaimed; provided, however, that, if a claim of a patent application has been pending for more than five (5) years from the national filing date, such claim will not constitute a Valid Claim for the purposes of this Agreement
unless and until a patent issues with such claim, provided, further, that, for purposes of the foregoing proviso, any newly filed claim which claims essentially the same subject matter as any earlier filed claim shall be considered pending for the
same period of time as such earlier filed claim has been pending. 

  

	B.	 Interpretation. 

 

	1.73	 Except where the context requires otherwise, whenever used the singular includes the plural, the plural
includes the singular, the use of any gender is applicable to all genders and the word “or” has the inclusive meaning represented by the phrase “and/or.” 

 

	1.74	 The term “including” or “includes” as used in this Agreement means including, without
limiting the generality of any description preceding such term. 

  

	1.75	 Whenever this Agreement refers to a number of days, unless otherwise specified, such number refers to calendar
days. 

  

	1.76	 The headings of this Agreement are for convenience of reference only and do not define, describe, extend or
limit the scope or intent of this Agreement or the scope or intent of any provision contained in this Agreement. 

  

	1.77	 The wording of this Agreement shall be deemed to be the wording mutually chosen by the Parties and no rule of
strict construction shall be applied against any Party. 

  

	2.	 PURPOSE OF THE COLLABORATION 

 

	2.1	 The aim of the Parties is to identify and validate Targets within the Target Field, carry out drug discovery
and to advance drug development candidates for Novo. The Parties will collaborate on mining, nominating, and validating Targets, will decide on the molecular format of Candidate Targets and jointly conduct drug discovery, as further specified in the
Research Plan. To this end, Evotec shall leverage its expertise, capabilities, and platform to design, implement and deliver (Candidate) Targets, compounds, leads, as well as biomarkers and patient stratification strategies. Novo

  
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may support the collaboration with its disease biology expertise, access to key opinion leaders as required, and preclinical and clinical development expertise. It is understood between
the Parties that, if the Compound is a Small Molecule Compound, Evotec shall conduct the drug discovery activities. If the Compound is not a Small Molecule Compound, Novo will conduct the drug discovery activities. 

 

	2.2	 Novo shall have the sole and exclusive right, but – for clarity, subject to Section 11.2 where so
indicated in this Agreement, shall not be obliged, to further develop and Commercialize any Products in the Territory for the diagnosis, prevention and/or treatment of diseases in humans, for any and all indications, and at its sole discretion.

  

	3.	 GENERAL PROVISIONS 

 

	3.1	 Scope. As of the Effective Date and under the governance referenced in Section 6, the Parties shall
conduct the Collaboration Activities in good scientific manner, and in compliance in all respects with the requirements of Applicable Laws, rules and regulations and diligent laboratory practices to achieve their objectives efficiently and
expeditiously. The Parties will conduct the research activities as specified in the Research Plan and the Projects that will be determined according to the selection process as set out in Section 3.1.4, where each Project shall address specific
Project Target(s). 

  

	3.2	 Subcontracting. Each Party may subcontract any tasks and obligations allocated to it under the
Collaboration Activities to its Affiliates. The subcontracting of any tasks or obligations allocated under a Project Plan to a Third Party shall require the prior written approval of the JSC, which approval shall not be unreasonably withheld. The
subcontracting Party (a) shall enter with such subcontracted Third Party into written agreements, containing terms which (b) are equal and as stringent as the terms set forth in this Agreement, including – without limitation - the
terms regarding timelines, record keeping and retention, confidentiality, publication, including the approval process, intellectual property and other relevant terms of this Agreement, (c) ensure a complete and valid assignment of any and all
rights to results, including inventions, generated in the course of the performance of subcontracted tasks to the subcontracting Party, and (d) shall be responsible and liable to the other Party for any breach of such terms by a subcontracted
Affiliate or Third Party and for the performance of the subcontracted tasks or obligations. 

  

	3.3	 Use of Data. Notwithstanding anything to the contrary in this Agreement, Novo hereby expressly agrees
that Evotec may use the Data in a blinded format for Evotec’s technology development. For clarity, ‘blinded format’ means that Evotec shall not make any reference to the molecular format of the Compound and the (Candidate) Target of
said Compound, Novo, and/or the Collaboration Activities. 

  

	3.4	 Efforts Employed. During the Collaboration Term the Parties shall use Commercially Reasonable Efforts to
perform the tasks allocated to them in the Research Plan and Project Plan(s) and agree to commit sufficient time, effort, equipment, skilled personnel, facilities and other resources reasonably necessary to carry out such tasks.

  
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	3.5	 Staffing Level.  

 

	 	3.5.1	 During the Collaboration Term of this Agreement and under the direction and supervision of the JRT, each Party
shall perform or cause to be performed its obligations under the Research Plan and Project Plans in good scientific manner and in compliance with all Applicable Laws. It is agreed that during the Collaboration Term Evotec, at Novo’s cost, shall
contribute up to an average of five (5) FTE during Target identification phase but in no case less than three (3) FTE; an average of two (2) but in no case less than one (1) FTE per Target during Target validation phase; and, if
the Compound is a Small Molecule Compound, an estimated number of four (4) FTE per Target (as will be further specified in the Project Plan) for each Project Target during screening phase; and an estimated number of twelve (12) FTE per
Project from hit-to-lead through lead optimization phase (as will be further specified in the Project Plan). 

 

	4.	 PHASES OF THE COLLABORATION 

 

	4.1	 Research Phase: Target Mining, Nomination, Validation. Under the Research Plan and as further defined
therein, the Parties shall collaborate on the identification and validation of (potential) Candidate Targets, which, in accordance with Section 6.2, will be nominated to the JSC for inclusion as Targets in the Target pool (“Target
Pool”). The JSC shall, unless it requires further information, decide within fourteen (14) Days from suggestion of Candidate Target whether or not to include such Candidate Target as a Target in the Target Pool. The Parties have agreed
that the Target Pool will consist of a maximum of [***] Targets at any given time during the Collaboration Activities. From the Target Pool, the JSC will select a Project Target. Unless the JSC decides otherwise, for each Project Target a
separate Project and Project Plan will be agreed upon. 

  

	4.2	 Project Phase: Drug Discovery from Compound to PDC. Under each Project, the Parties will collaborate on
the drug discovery for a Compound. A Project will be deemed completed once Novo’s internal decision committee, on the basis of the criteria set out in each Project Plan, has approved the Compound to be a PDC. Such approval will be at
Novo’s sole discretion. Notwithstanding such PDC approval, the JSC may decide to continue the relevant Project to further develop a Back-up PDC for the PDC. 

 

	4.3	 Achievement of PDC Approval Milestone Criteria. If it deems a Compound is ready for approval as a PDC as
referred to in Section 14.2.1, the JPT will prepare a proposal for decision and for submission by the JSC to Novo’s relevant internal decision committee. Approval of a Compound to be a PDC will be at Novo’s internal decision
committee’s sole discretion. 

  
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	5.	 EXCLUSIVITY 

  

	5.1	 Evotec Exclusivity. Evotec shall not, during the first calendar months after the Effective Date,
within the Target Field and subject to the exclusivity obligations under Section 5.2, for or with any Third Party, directly or indirectly, perform any target identification activities based on the unique kidney disease patient cohorts arising
out of the NURTuRE Consortium (“Evotec Exclusivity”). The Evotec Exclusivity shall be applicable only to new activities, and shall not be applicable if and to the extent that, on the Effective Date, Evotec is contractually obligated
to perform such target identification activities for a Third Party under a pre-existing written and valid agreement with such Third Party. 

 

	5.2	 Mining List. 

  

	 	5.2.1	 In addition to the Evotec Exclusivity and the Target Exclusivity under Section 5.3.1, the Parties have
agreed that, for the duration of [***] calendar months after the expiry of the Evotec Exclusivity, the Parties shall keep a dynamic list containing up to [***] potentially interesting targets that result from their data mining activities
performed under this Agreement (“Mining List”). Novo shall have the first and exclusive right to promote any target on the Mining List to become a Candidate Target. Evotec will notify Novo if a Third Party approaches Evotec with a
request to perform any services or other activities in respect of a target on the Mining List, giving Novo fourteen (14) Days to notify Evotec whether it wishes to promote such a target to become a Candidate Target. If Novo notifies Evotec that
it wishes to promote the target to become a Candidate Target, Evotec shall not work with any Third Party on such Target. If Novo decides against promoting the target to become a Candidate Target, the Parties shall each be free to work on such target
with a Third party. For clarity, subject to the license to Novo under Section 10.1.2, any targets on the Mining List shall remain Evotec’s Confidential Information. 

 

	5.3	 Target Exclusivity. 

 

	 	5.3.1	 The Parties have agreed to collaborate exclusively within the Target Field on all Targets (including any and
all Targets that became Project Targets) (“Target Exclusivity”). This means that, for the duration further specified in Section 5.3.3 neither Party, except within and for the purpose of their Collaboration Activities, shall
screen and/or generate (whether for itself or for any Third Party) any Know-How, Data, Compounds and inventions with regard to a Target within the Target Field. 

 

	 	5.3.2	 Each Party hereby covenants to the other Party that, prior to agreeing to submit a Candidate Target to the JSC,
such Party’s Alliance Manager, in their role as gate keeper of such Party under Section 6.2, will conduct an internal review to confirm that such Party is not prevented from working exclusively with the other Party on the Candidate Target
as set out in this Section 5.3. During the two (2) week nomination period for a Candidate Target to be included as a Target in the Target Pool, Evotec shall be obliged to work exclusively with Novo on all Candidate Targets unless it is
expressly prohibited from doing so under a pre-existing written and valid agreement with a Third Party. 

  
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	 	5.3.3	 The Target exclusivity under this Section 5.3 shall be in effect for a minimum period of [***] from the
date the JSC decides to include such Target in the Target Pool, provided that during this period the Parties are actively pursuing target validation work on such Target using Commercially Reasonable Efforts as defined in Section 3.4. The
minimum period of Target exclusivity will be extended by a single [***] period if, upon expiry of the [***] period, (i) the JSC decides that further validation of the Target is needed before it can decide whether the Target can progress to
become a Project Target; and (ii) the Parties are continuously pursuing target validation work on such Target using Commercially Reasonable Efforts as defined in Section 3.4. Upon expiry of the aforementioned minimum period of exclusivity
for a specific Target, the Parties’ respective exclusivity obligations with respect to such Target shall terminate. 

  

	 	5.3.4	 Notwithstanding the foregoing, Evotec’s Target Exclusivity obligations under this Section 5.3 shall
remain in effect in respect of any Target(s) as long as Novo uses Commercially Reasonable Efforts to develop and Commercialize a Product that includes or consists of a PDC with a Compound that modulates such Target(s). 

 

	 	5.3.5	 For clarity, Evotec (subject to its obligations under Sections 5.1, 5.2, 9.5 and 17) and Novo shall be free to,
independently and outside of the Collaboration Activities, work or continue to work on: 

  

	 	a.	 Candidate Targets to which the Target Exclusivity under Section 5.3 does not apply; 

and 
  

	 	b.	 Targets removed from the Target Pool by decision of the JSC. 

 

	 	c.	 Notwithstanding the foregoing, if, during the Collaboration Activities, Novo acquires from a Third Party a
programme with a target identical to a Target, Novo shall have the right, but not the obligation: 

  

	 	i.	 to have the JSC remove the relevant Target from the Target Pool or to terminate the Project for such Target,
upon which removal or termination (i) the Evotec’s exclusivity obligations under Sections 5.1 and 5.2 and (ii) the Target Exclusivity under Section 5.3 shall no longer apply, meaning that both Parties shall be free to work on the
removed target within and outside of the Target Field and with immediate effect; or 

  

	 	ii.	 after expiry of the minimum period of exclusivity referenced in Section 5.3.3, to work on both the Third
Party programme and continue to use Commercially Reasonable Efforts with the Collaboration Activities in respect of the Target under this Agreement. For clarity, the target of any such Third

  
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Party programme shall not be considered a Target under this Agreement, and any compound developed for a target under such Third Party programme shall not be considered a Compound under this
Agreement. Notwithstanding Section 10.1.2 (c), any Target Data licensed to Novo will not be shared with such Third Party. 

  

	5.4	 Exceptions to Exclusivity 

 

	 	5.4.1	 The exclusivity granted by Evotec pursuant to Sections 5.1 to 5.3 shall not prevent Evotec from:

  

	 	a)	 conducting screens on Target(s) if, (a) so requested by a Third Party or Affiliate and (b) solely in
connection with screening to determine whether a certain compound has off-target activity. By way of example, if target A is a Target, and target B is a separate target, then Evotec would have the right to
screen compounds that a Third Party is evaluating for use in connection with target B in a counter-screen containing Target A solely in order to attempt to determine whether such compounds have off-target activity against Target A. Evotec would,
however, not be permitted to subsequently convert any findings into new target projects with or on behalf of such Third Party; 

  

	 	b)	 determining biophysical properties (Kd, Ki, Kon, Koff, DH, DS) as part of compound screening and profiling
campaigns; 

  

	 	c)	 determining target protein-ligand complex structures by X-Ray
crystallography and related methods if, (a) the Target is a target that was already in the public domain and (b) such ligands/compounds are provided by the Third Party; and 

 

	 	d)	 conducting fee for service protein, cells, probes and other reagent production, without using any gene
constructs that are part of this Agreement; and 

  

	 	e)	 conducting any development activities outside of the Target Field, including IND enabling studies, CMC,
formulation and API manufacture on candidate molecules as identified by a Third Party where the target might be known but is not required to perform the scope of work. 

 

	6.	 GOVERNANCE 

  

	6.1	 General. In order to fulfil the objectives of the Collaboration Activities, the Parties agree to each
appoint an Alliance Manager and to establish a formal framework for the duration of the Collaboration Activities, consisting of a Joint Research Team (JRT), a Joint Project Team for each Project Target (JPT) and a Joint Steering Committee (JSC)
within which the Parties shall, subject to the provisions of this Agreement, prepare and adopt strategies for the implementation and execution of the Research Plan and any Project Plans. Each such committee shall have an equal number of
representatives from each Party, which shall be designated by each Party and be functionally aligned with each other. Meetings shall be conducted in person or by telephone or video 

  
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conference or via electronic means as agreed by the Parties. Each such committee shall be co-chaired by a representative of each Party and decisions shall
be made by unanimous consensus of its members, subject to the provisions of this Section 6. The location of the meeting of each such committee shall alternate between sites selected by each Party. 

 

	6.2	 Alliance Managers. 

 

	 	6.2.1	 Appointment and General Tasks of Alliance Managers. Upon the Effective Date, each Party will appoint and
will maintain one employee to oversee the contact between the Parties, to, alternately, organize, run, and write minutes during the JSC meetings and to have such other responsibilities as referenced in the Research Plan and as may be agreed in
writing after the Effective Date (each, an “Alliance Manager”). 

  

	 	6.2.2	 Specific Tasks of Alliance Managers: Gate Keeping. 

 

	 	a)	 The Alliance Manager of each Party shall act as sole and exclusive gate keeper for said Party as referenced in
Section 5.3.2. In its role of gate keeper, the Alliance Manager of a Party will conduct all internal reviews to confirm that such Party is not prevented from working exclusively with the other Party on the Candidate Target as set out in this
Section 5.2. 

  

	 	b)	 Each Party hereby warrants to the other Party that its Alliance Manager shall treat the fact that a Candidate
Target is considered for a Target strictly confidential and shall not share any Data on Candidate Targets (a) within its Party’s organization, including its Affiliates, other than on a need-to-know basis, or (b) with any Third Parties. 

  

	6.3	 Joint Research Team (JRT).  

 

	 	6.3.1	 Establishment and tasks of JRT. Within thirty (30) days of the Effective Date and for the duration
of the Collaboration Term, the Parties shall establish and maintain a joint research team (“Joint Research Team” or “JRT”). The JRT shall be responsible for the general alignment and progression of the Parties’
joint research activities as set out in the Research Plan. As further specified in the Research Plan, the JRT shall meet on a regular basis, shall consist of an equal number of scientific representatives of each Party and shall report to the JSC. In
particular, the JRT shall have the following tasks: 

  

	 	a)	 executing the Collaboration Activities specified in the Research Plan; 

 

	 	b)	 reviewing the data from the Target mining, identification and preliminary validation; 

 

	 	c)	 selection and nomination of Targets for the Target Pool; 

 

	 	d)	 regularly updating the Research Plan. 

  
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	 	6.3.2	 Formation of JRT. Each Party shall appoint the relevant members of the JRT within thirty
(30) days after the Effective Date. Each Party may designate substitutes for a member unable to attend a meeting or replace a member by a new member at any time by written notice, whereas substitutions shall be limited to the extent possible.
Each Party shall furthermore designate one member of the JRT as manager (“JRT Managers”). The JRT Managers will alternately be responsible for organizing the meetings of the JRT and for distributing the agenda of the meetings. In
order to ensure regular information of the JSC on the research activities conducted under the Research Plan, the JPT Managers may be invited to the meetings of the JSC to give updates as needed. 

 

	 	6.3.3	 Dispute Resolution. If the JRT is unable to reach a decision on a matter, such matter shall be resolved
in a second meeting to be held within twenty (20) Business Days from the meeting in which the disputed matter has remained unsolved. In the event that the JRT is again unable to resolve the matter the disputed matter shall be promptly referred
to the JSC for resolution. 

  

	6.4	 Joint Project Team (JPT). 

 

	 	6.4.1	 Establishment and tasks of JPT. For each individual Project Target, the Parties shall establish a joint
project team (“Joint Project Team” or “JPT”) and maintain such JPT during the term of the relevant Project. The JPT shall be responsible for the implementation and conduct of the Research Plan on a Project Target-by- Project Target basis. The JPT shall report to the JSC. In particular, the JPT shall have the following tasks: 

 

	 	a)	 developing and proposing a Project Plan and amendments thereto; 

 

	 	b)	 the day-to-day implementation
and management of the Collaboration Activities in connection with each Project Plan; 

  

	 	c)	 the oversight of timelines and costs; 

 

	 	d)	 proposing the strategic research goals and directions for a Project; 

 

	 	e)	 preparing and proposing milestones, go/no go criteria of each Project; 

 

	 	f)	 executing a Project; 

 

	 	g)	 monitoring the progress of a Project; 

 

	 	h)	 proposing priorities within a Project; 

 

	 	i)	 recommending a PDC to the JSC; 

 

	 	j)	 preparing semi-annual detailed reports to be provided to JSC. The Parties have agreed that if the Compound is a
Small Molecule Compound, Evotec’s JPT Manager shall be responsible for preparing said report. If the Compound is not a Small Molecule Compound, Novo shall be responsible for preparing the report. 

  
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	 	6.4.2	 Formation of JPT. Each Party shall appoint the relevant members of the JPT within thirty
(30) days following the written agreement on the respective Project Plan. The members of the JPT will be decided Project-wise for Evotec by Evotec JSC members and for Novo by Novo JSC members. In general, each JPT shall comprise of a minimum of
one (1) pharmacologist and one (1) chemist from each Party. Each Party may designate substitutes for a member unable to attend a meeting or replace a member by a new member at any time by written notice, whereas substitutions shall be
limited to the extent possible. Each Party shall furthermore designate one member of the JPT as JPT manager (“JPT Managers”). In order to ensure regular information of the JSC on the progress within a Project, the JPT Managers will
be invited to the meetings of the JSC to give updates as needed. 

  

	 	6.4.3	 Meetings and Decisions of the Joint Project Team. The JPT shall meet on a regular basis, but at least
every month. The JPT members will meet personally at the offices of Novo and Evotec or on another location or another meeting mode, e.g. telephone or video conference. Representatives of each Party other than the members of the JPT may attend JPT
meetings at the invitation of either Party with the prior approval of the other Party, which approval shall not be unreasonably withheld. The JPT Managers will alternately be responsible for organizing the meetings of the JPT and for distributing
the agenda of the meetings. The responsible JPT Manager shall also prepare and update an action plan after the meetings which shall be sent to the other Party for review and approval not later than seven (7) Business Days after the meeting. The
Parties shall then execute a final version of the action plan within additional seven (7) Business Days. In case of any objections against the accuracy or completeness of such action plan the reviewing Party will provide a written notice to the
other members of the JPT. In the event that any such objection is not resolved by mutual agreement of the Parties, the action plan will be amended to reflect such unresolved dispute for Dispute Resolution. 

 

	 	6.4.4	 Dispute Resolution. If the JPT is unable to reach a decision on a matter, such matter shall be resolved
in a second meeting to be held within twenty (20) Business Days from the meeting in which the disputed matter has remained unsolved. In the event that the JPT is again unable to resolve the matter the disputed matter shall be promptly referred
to the JSC for resolution. 

  

	6.5	 Joint Steering Committee (JSC). 

 

	 	6.5.1	 Establishment and tasks of the JSC. The Parties shall establish a joint steering committee
(“Joint Steering Committee” or “JSC”) and maintain such JSC during the Collaboration Term. The JSC shall be responsible for the supervision and overall execution of the Collaboration Activities
and make final decisions based on the proposals of the JRT and JPT. In particular, it shall have the following tasks: 

  

	 	(a)	 the approval of the strategic research goals, priorities and the direction for the Projects;

  
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	 	(b)	 the decision of the molecular format for a Target; 

 

	 	(c)	 the selection and replacement of Targets and Project Targets, Compounds and PDCs; 

 

	 	(d)	 the approval of each Project budget, resources and resource allocation. For clarity, approval of the Project
budget and changes in the same will also require Novo’s internal governance approval; 

  

	 	(e)	 the approval the go/no go criteria and criteria for evaluation of the Projects; 

 

	 	(f)	 endorsing and the submission of Milestone achievement to the relevant Novo internal committee for final
decision and reporting on the Research and Development Milestones, provided always that no such decision shall be taken unless reasonably detailed information pertaining thereto has been submitted to the JSC in writing at least two (2) weeks
prior to the meeting; 

  

	 	(g)	 approving each Project Plan and any major change thereto and any
non-fundamental scientific amendments thereto; 

  

	 	(h)	 approving the workflow and allocation of resources for carrying out the Projects; 

 

	 	(i)	 approving priorities for the Projects and capacities of the Parties; 

 

	 	(j)	 monitoring timely execution of the Project Plans; 

 

	 	(k)	 approving major outsourcing or collaboration agreements with Third Parties as appropriate;

  

	 	(l)	 approving the publication strategies; 

 

	 	(m)	 resolving any issues that could not be resolved by the JRT and/or the JPT; 

 

	 	(n)	 taking all other significant decisions relating to the Collaboration Activities. 

 

	 	6.5.2	 Formation of the JSC. Within thirty (30) days of the Effective Date, each Party shall appoint two
(2) of its senior research staff to the JSC. Each Party may designate substitutes with appropriate authority for a member unable to attend a meeting or replace a member by a new member at any time by written notice. 

 

	 	6.5.3	 Meetings and decisions of the JSC. The JSC shall meet from time to time, but at least on a
semi-annual basis. Each Party may, through its Alliance Manager, call a JSC meeting with not less than twenty (20) Business Days prior notice to the other, unless such notice is waived, and meetings shall be held alternately at the offices of
Novo and Evotec, unless the Parties agree on another location. Instead of having a personal meeting the Parties may also agree from time to time to hold a JSC meeting by video or telephone conference or to take decisions in writing. Representatives
of each Party other than the members of the JSC may attend JSC meetings at the invitation of either Party with the prior approval of the other Party, which approval shall not be unreasonably withheld. 

  
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	 	6.5.4	 Dispute Resolution. In the event that the JSC cannot reach consensus on a matter within thirty
(30) Business Days, such matter shall be referred to a Novo executive (SVP level or above) who shall have the final decision-making authority, and such decisions shall be binding on the Parties, provided such decisions are made in good faith
and consistent with the provisions of this Agreement. 

  

	 	6.5.5	 Limitation of Power of the Joint Steering Committee. The JSC will not have any power to amend this
Agreement and will have only such powers as are specifically delegated to it under this Agreement. 

  

	6.6	 Replacement of Personnel. Each Party shall have the right, at any time, to designate by written
notice to the other Party a replacement for any of such Parties’ members on any of the committees mentioned in this Section 6, provided in such replacement has a functionally equivalent position (regardless of title) to the person being
replaced. 

  

	6.7	 Expenses. Each Party shall bear its own costs including travelling costs, for personnel serving on the
committees mentioned in this Section 6. 

  

	7.	 TECHNICAL INFORMATION, INFORMATION EXCHANGE, MATERIALS 

 

	7.1	 Information Exchange. The Parties shall and shall cause their Affiliates, without additional
compensation and at each Party’s sole expense, to make available to each other within thirty (30) days of the other Party’s request, all relevant technical information and material incorporating the Party’s Background IP
necessary to initiate and conduct the Projects. Each Party shall use the technical information and materials obtained from the other Party only to the extent needed for the performance of its respective Collaboration Activities.

  

	7.2	 Information Update. During the Collaboration Term, the Parties shall disclose and make available to each
other without charge any Project IPR and relevant new items of Background IP for use within the scope of the Collaboration Activities. Notwithstanding the foregoing, each Party shall only be required to provide or disclose to the other Party such
parts of its technology and materials incorporated in the Background IP as it reasonably determines to be necessary for the other Party to perform its Collaboration Activities. Notwithstanding anything contained in this Agreement to the contrary,
neither Party shall have any obligation to provide to the other Party any proprietary compounds, technology, information or materials that are unrelated to, or are not reasonably necessary for, the performance of the Collaboration Activities.

  
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	7.3	 Materials. If either Party provides or makes available to the other any Materials, the following shall
apply: the receiving Party will not make the Material available to a Third Party without the prior written consent of the other Party and will make Material available to Affiliates only on a need-to-know basis for the performance of subcontracted activities under the Collaboration Activities or, with respect to Novo, for the further development and Commercialization of Products. Any unused
portion of the Material will be, at the providing Party’s option, either returned to the providing Party upon completion of a Project or termination of the Agreement (whichever is relevant), or destroyed, whereas Novo shall be entitled to use
any Material for the further development and Commercialization of Products. Unless provided otherwise herein, the receiving Party shall not use any Material provided to it by the other Party for any purpose other than in connection with this
Agreement. In all other respects, Material shall be treated as Confidential Information pursuant to Section 17. Each Party shall use, store and handle any Material provided to it by the other Party in accordance with all Applicable Laws
relating thereto and written instructions provided by the other Party. 

 The providing Party shall not be liable for and
shall be indemnified by the other Party against any loss, claim, damage or liability which may arise from the use, storage or handling of the Material by the other Party except to the extent that any damages have been caused by the providing
Party’s gross negligence or wilful misconduct. 
  

	7.4	 Assistance. Each Party shall cooperate with any and all reasonable requests for assistance from the
other Party with respect to the Collaboration Activities. 

  

	8.	 RECORDS AND REPORTS 

 

	8.1	 Record Keeping. Each Party shall prepare and maintain, or cause to be prepared and maintained, complete
and accurate written records pertaining to its respective Collaboration Activities within a Project in sufficient detail and in good scientific manner fully compliant with patent and regulatory purposes, which shall be complete and accurate and
shall fully and properly reflect all work done and results achieved in the performance of its respective Collaboration Activities under a Project Plan, and which shall be retained by such Party for at least 5 (five) years after the termination of
this Agreement, or for such longer period as may be required by any Applicable Laws. Such records shall be maintained in English. 

  

	8.2	 Record Inspection. Each Party shall make such records available for inspection by the other Party at all
reasonable times and deliver copies of such records to the other Party at the other Party’s reasonable request and cost. 

  

	8.3	 Reports. Each Party will provide the JSC with regular oral or written reports detailing its
Collaboration Activities under the Project Plans and the Project IPR. Detailed reports shall be submitted to the JSC at least twice a year, namely in each case at least 10 (ten) Business Days prior to the regular JSC meetings. 

  
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	9.	 IP, IMPROVEMENTS AND DATA OWNERSHIP AND TRANSFER 

 

	9.1	 Ownership of Background IP. Subject to the rights granted to Evotec under Section 10.2, Novo
shall retain all rights, title, interest and ownership in and to Novo Background IP. Subject to the rights granted to Novo under Section 10.1, Evotec shall retain all rights, title, interest and ownership in and to Evotec Background IP.

  

	9.2	 Improvements. 

 

	 	9.2.1	 Ownership of Improvements. All right, title and interest in and to the Improvements of Novo’s
Background IP, and Patent Rights filed for and/or obtained in respect of the same, shall vest in Novo. All right, title and interest in and to the Improvements of Evotec’s Background IP, and Patent Rights filed for and/or obtained in respect of
the same, shall vest in Evotec. For clarity, Party’s Improvements will be automatically included in the license granted by such Party to the other Party under Section 10. 

 

	 	9.2.2	 Notification of Improvements. Each Party shall promptly inform the other Party in writing of any
significant Improvements that may result out of the first-mentioned Party’s performance of the Collaboration Activities. 

  

	 	9.2.3	 Assignment of Improvements. Novo hereby assigns to Evotec, and Evotec hereby accepts, all of its right,
title and interest in and to any Improvements of the Background IP of Evotec and Novo shall ensure that its employees and agents promptly assign to Evotec any rights that they may have in or to such Improvements. Evotec hereby assigns to Novo, and
Novo hereby accepts, all of its right, title and interest in and to any Improvements of the Background IP of Novo and Evotec shall ensure that its employees and agents promptly assign to Novo any rights that they may have in or to such Improvements.
Each Party shall cooperate with the other Party, including but not limited to executing and delivering any instrument required to assign or transfer such Improvements to the other Party in accordance with this Section 9.2.

  

	9.3	 Data. 

  

	 	9.3.1	 Ownership of Data. All right, title and interest in and to the Compound Data shall vest in Novo and
shall be considered Novo’s Confidential Information. All right, title and interest in and to the Target Data shall vest in Evotec and shall be considered Evotec’s Confidential Information. For clarity, any right, title and interest in Data
with regard to Candidate Targets proposed by Novo shall vest in Novo and shall be considered Novo’ Confidential Information. 

  

	 	9.3.2	 Assignment of Data. Novo hereby assigns to Evotec, and Evotec hereby accepts, all of its right, title
and interest in and to any Target Data. Evotec hereby assigns to Novo, and Novo hereby accepts, all of its right, title and interest in and to any Compound Data. Each Party shall cooperate with the other Party, including but not limited to
transferring the Data to the other Party in accordance with this Section 9.3. 

  
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	9.4	 Ownership of Compounds, Compound Data and Compound Patents.  

 

	 	9.4.1	 Novo shall be the exclusive owner of all Compounds and all Compound Data, including any results, inventions,
information and other Intellectual Property Rights relating thereto as generated under the Collaboration Activities, including all Know-How with regard to the relevance of a Hit within the Target Field by
virtue of its affinity for a Target, and shall have the sole and exclusive right to apply for Patent Rights in and to the same, including Compound Patents. In case inventors employed by Evotec or otherwise entrusted by Evotec to carry out work under
this Agreement will have to be designated as inventors in connection with Compound Patents, any rights, title and interest of such persons relating to such Compound Patents shall be, and are hereby, fully transferred by Evotec to Novo according to
Section 9.9.1. 

  

	 	9.4.2	 Evotec shall provide Novo with any and all assistance reasonably requested by Novo in connection with any
Compound Patent applications filed in accordance with Section 9.4.1 at Novo’s expense, including but not limited to the making of assignments and the execution of documents for the prosecution of any of such Compound Patent applications.
Evotec shall not research or develop the Compound, including any derivatives thereof that are made under this Collaboration, or any activities Covered by the Compound Patents outside of the Collaboration Activities or add such Compounds, or
derivatives thereof that are made under this Collaboration, to the Evotec Library. 

  

	9.5	 Ownership of Sole Project IPR, Data and Know-How. Unless
stipulated otherwise in Sections 9.1 through 9.7, and subject to the mutual rights granted under Section 10.3, each Party shall be the sole and exclusive owner of any and all Project IPR, Data and
Know-How which are made solely by such Party within the Collaboration Activities. 

  

	9.6	 Ownership of Joint Project IPR, Data and Know-How. Unless
stipulated otherwise in Sections 9.1 through 9.7, and subject to the mutual rights granted under Section 10.3, Project IPR, Data and Know-How which have been made under the Collaboration Activities and to
which inventors from both Parties have contributed shall be jointly owned by the Parties. 

  

	9.7	 Rights relating to Evotec Library Compounds and Hits. Subject to the rights granted to Novo under
Section 10.1, as between the Parties, Evotec shall own the rights, including Intellectual Property Rights, in the Evotec Library Compounds. As a result, for clarity, Evotec is free to use the Evotec Library Compounds outside of the
Collaboration Activities but is not allowed to divulge or use the Know-How that such certain Evotec Library Compound has shown affinity to a Target. 

 

	9.8	 Ownership of Post-Collaboration IPR. For the avoidance of doubt, Novo shall be the exclusive owner of
any and all Know-How, Data, inventions and Patent Rights generated by or on behalf of Novo after the Collaboration Term, including Novo Post-Collaboration IPR. 

  
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	9.9	 Patent Prosecution, Enforcement and Maintenance 

 

	 	9.9.1	 Patent Prosecution and Maintenance of Compound Patents and Novo Post-Collaboration IPR. Novo shall be
the sole and exclusive owner of all Compound Patents and all Novo Post-Collaboration IPR. Novo shall be responsible at its own costs for the drafting, filing, prosecution, maintenance and enforcement of the Compound Patents and any Novo
Post-Collaboration IPR, including the defense and settlement of claims from Third Parties regarding such Compound Patents and Novo Post-Collaboration IPR. Evotec shall ensure that any rights, title and interest in inventions covered by applications
for such Compound Patents and Novo Post-Collaboration IPR, which rights, title and interest have originated (i) from inventors employed by Evotec or (ii) from inventors entrusted by Evotec to carry out work under the Collaboration
Activities, shall be fully transferred to Evotec by appropriate means and Evotec herewith assigns to Novo any rights, title and interest in the Compound Patents and Novo Post-Collaboration IPR. Evotec shall reasonably cooperate with and assist the
Novo in the prosecution, maintenance and enforcement of any Compound Patent and any Novo Post-Collaboration IPR, including by (i) consulting with Novo as it may reasonably request, and (ii) making its relevant and necessary scientists and
scientific records reasonably available. In addition, Evotec shall sign and deliver, or use reasonable efforts to have signed and delivered, at Novo’s expenses, all documents necessary in connection with such prosecution, maintenance and
enforcement 

  

	 	9.9.2	 Patent Prosecution and Maintenance of Sole Project IPR. Each Party shall be responsible, without the
obligation to do so, for the filing, prosecution, maintenance, defence and enforcement of any Patent Rights in connection with its sole Project IPR at its own expense. 

 

	 	9.9.3	 Patent Prosecution and Maintenance of Joint Project IPR. Novo shall have the first right but not the
obligation to file (in the name of both Parties), prosecute, maintain, defend and enforce Patent Rights Covering joint Project IPR (“Project Invention”). The Parties shall reasonably cooperate in the prosecution of such Patent
Rights. Costs for such Patent Rights shall be borne by the Parties according to the respective share of the Parties in such Project Invention. 

  

	 	9.9.4	 In the event that at any time during the Collaboration Term of this Agreement or within three (3) months
after the date of expiry termination of this Agreement, Novo decides not to apply for Patent Rights for joint Project IPR or should intend to abandon or allow any such Patent Rights to be abandoned, Novo shall first offer to Evotec the opportunity
to take over Novo’s share in such Patent Rights and the responsibility for prosecution and maintenance of such Patent Rights. In the event that at any time during the Collaboration Term of this Agreement Evotec should decide not to take over a
share of such Patent Rights corresponding to Novo’s share in the joint Project Invention, Evotec shall offer to Novo to take over Evotec’s share in such Patent Rights. 

  
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	 	9.9.5	 Notice. Each Party shall promptly notify the other Party in writing upon learning of any (a) actual
or suspected infringement and/or misappropriation by a Third Party of a Party’s Background IP, Project Invention, Compound Patent or Novo Post-Collaboration IPR, or (b) a claim by a Third Party of invalidity, unenforceability and/or non-infringement of a Party’s Background IP, Project Invention, Compound Patent or Novo Post-Collaboration IPR. In the event that Novo and/or Evotec are sued or threatened with a suit by a Third Party
which claims that work carried out under the Collaboration Activities is an infringement of a Patent Right owned by the Third Party, the Parties shall consult with each other as to the best manner to proceed. 

 

	 	9.9.6	 Recovery. Neither Party shall enter into any settlement or compromise of any action under
Section 9.9.5 which would in any manner alter, diminish, or be in derogation of the other Party’s rights under this Agreement without the prior written consent of the other Party, which shall not be unreasonably withheld. Except as
otherwise provided, the costs and expenses of the Party bringing suit against a Third Party shall be borne by such Party, and any damages, settlements or other monetary awards recovered shall be shared as follows: (a) the amount of such
recovery actually received by the Party controlling such action shall first be applied to the out-of-pocket costs of each Party in connection with such action; and then
(b) the remainder of the recovery shall be treated as Net Sales hereunder if the suit was brought by Novo. If the suit was brought by Evotec, Evotec shall be entitled to recover the full award. The Parties shall agree in good faith the value of
any non-monetary benefits. 

  

	10.	 LICENSES 

  

	10.1	 License to Novo. 

 

	 	10.1.1	 Non-exclusive License to Evotec Background IP. Evotec hereby
grants to Novo, free of charge, the non-exclusive, world-wide, perpetual, irrevocable, and, in accordance with Section 14.4 royalty-bearing, rights to use, exploit and sublicense through multiple tiers,
the Evotec Background IP for the sole purpose of developing and Commercialising Products in the Territory, without the right to provide commercial contract research services to Third Parties. 

 

	 	10.1.2	 License to Target Data. 

 

	 	a.	 For the duration of the Target Exclusivity for a specific Target as referred to in Section 5.3.3 and
subject to Section 5.4, Evotec hereby grants to Novo the sole and exclusive, world-wide and (in accordance with Section 14.4) royalty-bearing right to use, exploit and sublicense through multiple tiers, the Target Data of such Target,
without the right to provide commercial contract research services to Third Parties. 

  

	 	b.	 If and to the extent the Target Exclusivity for a specific Target as referred to in Section 5.3.3 does not
apply, Evotec hereby grants to Novo, free of charge, the non-exclusive, world-wide, perpetual, irrevocable, right to use and sublicense through multiple tiers, the Target Data, without the right to provide
commercial contract research services to Third Parties. 

  
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	 	c.	 Any Target Data licensed to Novo under this Section 10.1.2 shall remain Evotec’s Confidential
Information but, in deviation of Section 17.1, Novo shall be allowed to share such Target Data with its collaboration partners and subcontractors. 

  

	 	10.1.3	 Non-exclusive right to Evotec Library Compounds. If and to the
extent a Compound is developed from, or incorporates, an Evotec Library Compound, Evotec hereby grants to Novo, free of charge, non-exclusive, world-wide, perpetual, irrevocable, rights to use and sublicense
through multiple tiers such Evotec Library Compound, and all Intellectual Property Rights owned or Controlled by Evotec Covering the same, for the further development and Commercialization of Products in the Territory, without the right to provide
commercial contract research services to Third Parties. 

  

	10.2	 License to Evotec. Novo hereby grants to Evotec and its Affiliates
non-exclusive, world-wide, perpetual, irrevocable, fully paid-up and royalty-free rights to use the Novo Background IP for the sole purpose of fulfilling Evotec’s
obligations under the Collaboration Activities. 

  

	10.3	 Mutual License to Data, joint Know-How and Project IPR.
Evotec hereby grants to Novo non-exclusive, world-wide, perpetual, irrevocable, fully paid-up and royalty-free rights to use and exploit Evotec’s sole Project
IPR, Data and Know-How and its interest in the joint Data, the joint Know-How and the joint Project IPR according to Sections 9.5 and 9.6 for any purpose whatsoever,
without the right to provide commercial contract research services to Third Parties. Novo hereby grants to Evotec non-exclusive, world-wide, perpetual, irrevocable, fully
paid-up and royalty-free rights to use and exploit Novo’s sole Project IPR, Data and Know-How and its interest in the joint Data, the joint Know-How and the joint Project IPR according to Sections 9.5 and 9.6 for any purpose whatsoever. 

  

	10.4	 No Implied Rights. No right or license under any Intellectual Property Right is granted or shall be
granted by implication under this Agreement. Any rights or licenses are or shall be granted only as expressly provided in the terms of this Agreement. 

  

	11.	 FURTHER DEVELOPMENT AND COMMERCIALIZATION OF PRODUCTS 

 

	11.1	 During and after the Collaboration Term and subject to Section 14, Novo shall have the sole and exclusive
right, but shall not be obliged, to independently further develop and Commercialize Products at its sole discretion. 

  

	12.	 MANUFACTURE AND SUPPLY, REGULATORY MATTERS 

 

	12.1	 Manufacture and Supply. Novo will be solely responsible for the manufacture and supply, either by
itself, Affiliates or Third Parties, of the Products in the Territory. 

  
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	12.2	 Regulatory Matters. Novo will be responsible for the preparation, filing, prosecution and maintenance of
any IND and NDA for the Products in the Territory. Upon request of Novo, Evotec will assist Novo, as may be reasonably necessary, in the preparation of respective IND or NDA to Regulatory Authorities, including providing necessary documents or other
materials required by Applicable Laws. Novo will be responsible for obtaining and maintaining any IND, NDA and Regulatory Approvals required for the Commercialization of Products in the Territory. Novo will be solely responsible for any
communications with Regulatory Authorities occurring or required in connection with obtaining or maintaining any INDs or NDA’s and Regulatory Approvals for the Products in the Territory. 

 

	13.	 COMPLIANCE 

  

	13.1	 In respect of any activities performed under this Agreement, each Party agrees to comply with Applicable Laws

  

	13.2	 Animal welfare. Evotec has read and understood the “Novo Nordisk Principles on the use of
animals” attached hereto as Annex B and agrees to adhere to and comply with these principles. Evotec shall give Novo access to its site upon reasonable notice that is not to be less than five (5) working days, in the event that Novo
wishes to perform an animal welfare (monitoring) inspection prior to or during the term of this Agreement. 

  

	13.3	 Use of Human bio samples and Personal Data. The Parties agree to comply, if and to the extent
applicable, with the “Human Biosamples and Personal Data” appendix attached hereto as Annex C and that they have complied and will comply with all applicable laws and regulations concerning the use of human tissue and/or human body fluid
for medical research purposes. 

  

	14.	 CONSIDERATION 

 

	14.1	 Upfront/ Exclusivity Fee and FTE support 

 

	 	14.1.1	 Upfront/ Exclusivity Fee. In consideration of the rights granted by Evotec to Novo under Section 5
this Agreement, Novo shall pay Evotec a non-refundable fee of [***] after execution of this Agreement and after receipt of a respective invoice from Evotec in accordance with Section 15.3. Such fee will
be unconditional and as such shall not be subject to any offset, credit, reduction or repayment for any reason whatsoever, whether provided for in this Agreement or not. 

 

	 	14.1.2	 FTE Support. As consideration for Evotec providing the FTE support set out in Section 3.5 and as
further specified in the Research Plan, Novo shall pay an amount of [***] per calendar year per FTE working on the Collaboration, without further claim for compensation from Evotec with respect thereto. Evotec shall invoice the FTE activities in
advance on a Calendar Quarter basis and shall adjust to actuals retroactively in the next Calendar Quarter. If reasonably necessary, the FTE resources may be adjusted, subject to the approval of the JSC. 

  
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	 	14.1.3	 Out-of-pocket expenses and
additional costs. In addition to the other payments under this Section 14, Novo shall reimburse Evotec for any reasonable out-of-pocket expenses. Additional
costs which could not have reasonably been expected, as well as additional efforts or work and changes in Evotec’s responsibilities and obligations hereunder, are not included and shall be remunerated separately. 

 

	 	14.1.4	 FTE Reporting. Evotec shall compile its FTE capacity reports based on its time recording systems by the
end of January of each year with respect to the previous calendar year. Evotec shall further ensure that such FTE capacity reports indicate the time spent on any particular work package of the then current Research Plan and/or Project Plan. Evotec
shall keep complete and accurate records of such FTE, as described in this Section 14.1.4 for purposes of verification and audit as set out in Section 16. Such records shall be open to inspection by Novo for a period ending three
(3) years after the relevant calendar year but not more than once per calendar year, by a nationally recognised independent certified public accountant selected by Novo to whom Evotec has no reasonable objections and retained at Novo’s
expense. Said accountant shall sign a confidentiality agreement prepared by Evotec and reasonably acceptable to Novo and shall then have the right to examine the records kept pursuant to this Agreement and report to Novo the findings (but not the
underlying data) of said examination of records as are necessary to evidence that the records were or were not maintained and used in accordance with this Agreement. A copy of any report provided to Novo by the accountant shall be given concurrently
to Evotec. If said examination of records reveals any discrepancy of more than five percent (5%), then Evotec shall bear the expenses of said accountant. 

  

	14.2	 Milestone Payments. 

 

	 	14.2.1	 PDC Approval Milestone. Upon approval of a PDC by Novo, on a Project-by-Project basis, Novo shall pay Evotec a non-refundable PDC Approval Milestone of [***] after receipt of a respective invoice from Evotec in accordance with
Section 15.3 This PDC Approval Milestone payment shall be payable only once per Project per approval of a PDC by Novo, and no amount shall be due for the subsequent PDC approval of a Back-up PDC within
the same Project. 

  
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	 	14.2.2	 R&D Milestones. Upon achievement of the following development and regulatory events, Novo will make
R&D Milestone payments as follows: 

  

									
	 R&D Milestone Event
	  	If the Product is a Small
Molecule Compound
R&D Milestone payment
in million Euro	 	 	If the Product is not a Small
Molecule Compound
R&D Milestone payment in
million Euro	 
	 Dosing of fifth (5th) patient in a Phase 1
Clinical Trial
	  	 	[	***] 	 	 	[	***] 
	 Dosing of fifth (5th) patient in a Phase 2
Clinical Trial
	  	 	[	***] 	 	 	[	***] 
	 Dosing of fifth (5th) patient in a Phase 3
Clinical Trial
	  	 	[	***] 	 	 	[	***] 
	 Regulatory Approval obtained in at least three (3) of the five (5) following countries:
DE, FR, IT, ES, UK
	  	 	[	***] 	 	 	[	***] 
	 Regulatory Approval by PMDA (Japan)
	  	 	[	***] 	 	 	[	***] 
	 Regulatory Approval by FDA (US)
	  	 	[	***] 	 	 	[	***] 
		  	  
	  
	 	 	  
	  
	 
	 Total R&D Milestones per Product
	  	 	[	***] 	 	 	[	***] 

  

	 	14.2.3	 For clarity, each R&D Milestone payment shall be payable only once per Product (i.e., for the first event
by the first Product regardless of the repeated achievement of the milestone event by the same Product). If Novo discontinues all exploitation of a particular Product after having made one or more milestone payments on the achievement of one or more
R&D Milestone events by such Product, there shall be no payment due upon the accomplishment of the same milestone event(s) for which such milestone payments were previously made with any Product used by Novo as a substitute, back-up, or replacement for the discontinued Product. 

  
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	14.2.4	 Sales Milestones. Upon achievement of the following sales events, Novo will make Sales Milestone
payments as follows: 

  

									
	 Sales Milestone Event
	  	If the Product is a Small
Molecule
Compound
Sales milestone payment
in million Euro	 	 	If the Product is not a
Small Molecule
Compound
Sales milestone payment
in million Euro	 
	 Annual Net Sales
  

> 1,000,000,000 EUR
	  	 	[	***] 	 	 	[	***] 
	 Annual Net Sales
  

> 2,000,000,000 EUR
	  	 	[	***] 	 	 	[	***] 
		  	  
	  
	 	 	  
	  
	 
	 Total Sales Milestones per Product
	  	 	[	***] 	 	 	[	***] 

  

	 	14.2.5	 For clarity, for the purpose of the above Sales Milestone payments, the annual Net Sales shall be calculated on
a Product-by-Product basis and shall be payable only once per Product. 

  

	14.3	 Reporting on Milestone Achievement and Payment. Novo shall provide written notice to Evotec of any
occurrence of any of the milestones set forth in Sections 14.2.2 and 14.2.4 no later than fifteen (15) working days following the occurrence of the relevant milestone. Novo will make the milestone payments in accordance with this
Section 14.2. 

  

	14.4	 Royalty Payments. 

 

	 	14.4.1	 Royalty Rates. Subject to the terms of this Agreement, in further consideration of the rights granted by
Evotec to Novo hereunder, including the licenses set forth in Section 10.1 above and in recognition of Evotec’s contribution to the realisation of Products, Novo shall pay to Evotec , on an incremental basis, the following royalties of Net
Sales of each Product Covered by a Valid Claim of a Compound Patent. 

  
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	 Royalty rate
	  	If the Product is a Small
Molecule
Compound	 	 	If the Product is not a
Small Molecule
Compound	 
	 Annual Net Sales
  

< [***] EUR
	  	 	[	***] 	 	 	[	***] 
	 Annual Net Sales
  

> [***] EUR –
  

< [***] EUR
	  	 	[	***] 	 	 	[	***] 
	 Annual Net Sales
  

> [***] EUR –
  

< [***] EUR
	  	 	[	***] 	 	 	[	***] 
	 > [***] EUR
	  	 	[	***] 	 	 	[	***] 

 By way of example, if the aggregate Net Sales of a Product that is a Small Molecule Compound in the Territory
amounts to the royalty payable for that period (without considering any applicable reductions or offsets) would be calculated as follows: [***] 
  

	 	14.4.2	 Royalty Term. The above royalty rates shall be payable on a country-by-country and Product-by-Product basis on the Net Sales of each Product from its First Commercial Sale and shall expire
on a country-by-country basis on the later of (i) the date of expiration of the last to expire Valid Claim of the Compound Patent in said country, or
(ii) [***] from the date of the First Commercial Sale of the Product in such country (“Royalty Term”). With regard to the calculation of the [***] period, the EU shall be considered one country. 

 

	 	14.4.3	 Know-How Royalties. If, during the Royalty Term, the Product is
not Covered by a Valid Claim of a Compound Patent in a country of the Territory in which the Product is sold, then Novo shall pay to Evotec a royalty reduced by [***] of the otherwise applicable royalty rate set forth in the table in
Section 14.4.1. 

  
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	 	14.4.4	 Third Party Payment Reduction. In the event that a Third Party Controls Intellectual Property Rights
relating to the Product that Novo in good faith deems is necessary or useful to get a license (or otherwise access) to in order to Commercialize the Product, then Novo shall have the right (but not the obligation) to obtain a license (or otherwise
access) to such Third-Party Intellectual Property Rights. The payments by Novo to Evotec under this Section 14 shall be subject to an offset equal to up to [***] of any payments Novo makes to such Third Party for a license or otherwise access
to such Intellectual Property Rights, provided however, that the maximum amount to offset will be [***] of payments otherwise payable by Novo to Evotec. 

  

	 	14.4.5	 Royalty Reporting. Each royalty payment shall be accompanied by a written report describing the Net
Sales of the Product during the respective Calendar Quarter in each country in the Territory in which such Net Sales occurred, specifying the Net Sales in each country’s currency, the applicable royalty rate under this Agreement, the royalties
payable in each country’s currency, including an accounting of deductions taken in the calculation of Net Sales, and the royalties payable in Euro. 

  

	 	14.4.6	 Method and Manner of Royalty Payment. Novo shall deliver to Evotec, within forty-five (45) days
following the end of each Calendar Quarter after the First Commercial Sale of the first Product, a royalty report as set forth in Section 14.4.5 along with Novo’s payment to Evotec of any royalty due and payable to Evotec for such Calendar
Quarter. All royalty payments shall be computed and paid in Euro. 

  

	15.	 PAYMENT AND TAXES 

 

	15.1	 Payment Method, Interest, and Exchange Rate. All payments under this Agreement will be made in EUR
regardless of the countries in which Net Sales are made. Net Sales made in currencies other than EUR will be converted into EUR using the exchange rate as used in Novo’s external accounting reporting process and in compliance with IFRS.

  

	15.2	 Evotec Account. Payment by Novo under this Agreement shall be made by wire transfer of immediately
available funds to the following account: 

  

	    	 [***] 

  

	15.3	 Invoicing. All agreed payments are net payments. All payments due under this Agreement shall be
paid within forty-five (45) days of receipt of a written invoice specifying the relevant payment and the amount due plus VAT if applicable, unless a different due date is indicated in this Agreement. Evotec shall invoice Novo according to
Novo’s invoicing instructions attached to this Agreement as Annex D. 

  
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	 	15.4	 Late Payments. Any payments due under this Agreement shall be due on such date as specified in this
Agreement. Any failure by Novo to make a payment within ten (10) days after the due date obligate Novo to pay interest on the due payment to Evotec. The interest period shall commence on the due date (inclusive) and end on the payment date
(exclusive). Interest shall be calculated based on the actual number of days in the interest period divided by 360 (three hundred sixty). The interest rate per annum shall be equal to the prevailing 1 (one) month Euro London Interbank Offered Rate
for the date that payment was due, as reported by the European Central Bank in Frankfurt, Germany, prior to the due date and reset to the prevailing 1 (one) month rate in monthly intervals thereafter, plus a premium of one (1) percentage
points, or shall be equal to an interest rate according to local legal provisions, whatever is lesser, but in any case not below zero (0). 

  

	15.5	 Taxes 

  

	 	15.5.1	 General. Evotec shall pay any and all taxes levied on account of all payments it receives under this
Agreement. All remunerations mentioned in this Agreement are net values. Value added tax, sales tax or similar taxes will be charged and invoiced additionally with the appropriate rate if legally required and has to be paid by Novo after receipt of
a correct invoice, which meets all legal requirements according to the applicable VAT law. 

  

	 	15.5.2	 Withholding Tax. If Novo is legally required to withhold any taxes from payments due hereunder, Novo
shall be entitled to deduct and withhold such taxes from the amount payable to Evotec. If Novo is required by law to deduct withholding tax, then the Parties shall co-operate in all respects and take all
reasonable steps necessary to (a) lawfully avoid the making of any such deduction or (b) to enable Evotec to obtain a tax credit in respect of the amount withheld. If the withholding tax rate is reduced according to the regulations in the
Double Tax Treaty, no deduction shall be made or a reduced amount shall be deducted only if Novo is timely furnished with necessary documents by Evotec, certifying that the payment is exempt from tax or subject to a reduced tax rate.

  

	 	15.5.3	 Any withheld tax shall be treated as having been paid by Novo to Evotec for all purposes of this Agreement.
Novo shall timely forward the tax receipts certifying the payments of withholding tax on behalf of Evotec. If Novo missed to deduct withholding tax but is still required by tax law to pay withholding tax on account of Evotec to the tax authorities,
Evotec shall assist Novo with regard to all procedures required in order to obtain reimbursement by tax authorities or, in case tax authorities will not reimburse withholding tax to Novo, Evotec will immediately refund the tax amount.

  
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	16.	 RECORDS AND AUDIT 

 

	16.1	 Record Maintenance and Audit. Novo will keep and maintain, and cause its Affiliates and licensees, who
have been granted rights to sell a Product, to keep and maintain, on a country-by-country basis for each Product complete and accurate records of sales of Product so
that the royalties payable and the royalty statements may be verified. Such records shall be, upon Evotec’s written request, during reasonable business hours and within thirty (30) days of such written request, open to inspection during
business hours for a three (3) year period after the royalty period to which such records relate, but in any event not more than once per calendar year, by a nationally recognised independent certified public accountant selected by Evotec among
either PWC, E&Y, KPMG or Deloitte to whom Novo has no reasonable objections and retained at Evotec’s expense. Said accountant shall sign a confidentiality agreement prepared by Evotec and reasonably acceptable to Novo and shall then have
the right to examine the records kept pursuant to this Agreement and report to Evotec the findings (but not the underlying data) of said examination of records as are necessary to evidence that the records were or were not maintained and used in
accordance with this Agreement. A copy of any report provided to Evotec by the accountant shall be given concurrently to Novo. If said examination of records reveals any underpayment(s) of the royalty payable, then Novo shall promptly pay the
balance due to Evotec, and if the underpayment(s) is/are more than 5%, then Novo shall also bear the expenses of said accountant. If said examination of records reveals any overpayment(s) of royalty payable, then Evotec shall either, at Novo’s
choice, pay the balance due to Novo or credit the amount overpaid against Novo’s future royalty payment(s), if any. 

  

	16.2	 Any records or accounting information received from Novo and the results shall be Novo’s Confidential
Information for the purpose of Section 17 and Evotec shall cause its accountant to comply with confidentiality provisions as stringent as set forth in Section 17. 

 

	16.3	 Audit Disagreement. If there is a dispute between the Parties following any audit performed pursuant to
Section 16.1, either Party may refer the issue (an “Audit Disagreement”) to an independent certified public accountant for resolution. In the event an Audit Disagreement is submitted for resolution by either Party, the Parties
shall comply with the following procedures. 

  

	 	(a)	 The Party submitting the Audit Disagreement for resolution shall provide written notice to the other Party that
it is invoking the procedures of this Section 16.3; 

  

	 	(b)	 Within thirty (30) days of the giving such notice, the Parties shall jointly select a recognized
international accounting firm to act as an independent expert to resolve such Audit Disagreement; 

  

	 	(c)	 The Audit Disagreement submitted for resolution shall be described by the Parties to the independent expert,
which description may be in written or oral form, within ten (10) Business Days of the selection of such independent expert; 

  
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	 	(d)	 The independent expert shall render a decision on the matter as soon as practicable; 

 

	 	(e)	 The decision of the independent expert shall be final and binding unless such Audit Disagreement involves
alleged fraud, breach of this Agreement or construction or interpretation of any of the terms and conditions thereof; 

  

	 	(f)	 All fees and expenses of the independent expert, including any third party support staff or other costs
incurred with respect to carrying out the procedures specified at the direction of the independent expert in connection with such Audit Disagreement, shall be borne by each Party in inverse proportion to the disputed amounts awarded to the Party by
the independent expert through such decision (e.g. the licensor disputes € 100, the independent expert awards the licensor € 60, then the licensor pays forty percent (40%) and the licensee pays sixty percent (60%) of the
independent expert’s costs). 

  

	17.	 CONFIDENTIALITY AND PUBLICATION 

 

	17.1	 Non-Disclosure of Confidential Information. Except as expressly
otherwise provided herein, the Parties agree that, for the term of this Agreement and for five (5) years thereafter, the Receiving Party will (a) use Commercially Reasonable Efforts to maintain in confidence Confidential Information of the
other Party in a manner similar to its own proprietary industrial information, however, not using less than a reasonable standard of care and not to disclose such Confidential Information to any Third Party without prior written consent of the
Disclosing Party, except for disclosure made in confidence to any Third Party under terms consistent with this Agreement and made in furtherance of this Agreement or of rights granted to a Party hereunder, and (b) not use such Disclosing
Party’s Confidential Information for any purpose except those permitted by this Agreement (it being understood that this subsection (b) shall not create or imply any rights or licenses not expressly granted under this Agreement).

  

	17.2	 Authorized Disclosure. Each Party may disclose Confidential Information belonging to the other
Party to the extent such disclosure is necessary in the following instances: 

  

	 	(a)	 filing or prosecuting Patents as permitted by this Agreement in order to obtain Patent Rights;

  

	 	(b)	 regulatory filings for Product(s) which such Party has a license to develop hereunder; 

 

	 	(c)	 complying with applicable court orders or governmental regulations or law. If the Receiving Party becomes
legally required to disclose any Confidential Information provided by the Disclosing Party, the Receiving Party will give the disclosing Party, to the extent reasonably possible, prompt notice of such fact so that the disclosing Party may obtain a
protective order or other appropriate remedy concerning such disclosure. The Receiving Party will make such disclosure only to the extent that such disclosure is legally required and will use its reasonable efforts to have confidential treatment
accorded to the disclosed Confidential Information; and 

  
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	 	(d)	 disclosure to (potential) Sublicensees provided that such Sublicensee agrees to be bound by similar terms of
confidentiality and non-use at least equivalent in scope to those set forth in this Section. 

  

	17.3	 For the avoidance of doubt, (a) Novo Background IP, the Compounds and the Intellectual Property Rights
related to the Compounds, Novo’s sole Project IPR and the Know-How with regard to the relevance of a Hit in the Target Field by virtue of its affinity to a Target, shall be considered Novo’s
Confidential Information and Evotec the Receiving Party in the meaning of this Section 17; (b) Evotec Background IP and Evotec’s sole Project IPR shall be considered Evotec’s Confidential Information and Novo the Receiving Party in
the meaning of this Section 17; and (c) the joint Project IPR, the Research Plan, the Project Plans, and the terms of this Agreement shall be considered Confidential Information of both Parties and each Party as Receiving Party in the
meaning of this Section 17. 

  

	17.4	 Public Domain. Specific aspects or details of Confidential Information shall not be deemed to be
within the public domain or in the possession of the Receiving Party merely because the Confidential Information is embraced by more general information in the public domain or in the possession of the Receiving Party. Further, any combination of
Confidential Information shall not be considered in the public domain or in the possession of the Receiving Party merely because individual elements of such Confidential Information are in the public domain or in the possession of the Receiving
Party unless the combination and its principles are in the public domain or in the possession of the Receiving Party. 

  

	17.5	 Publications. Notwithstanding the provisions of Section 22.7, Novo shall have the right to publish
or present information arising from the development of the Product, provided, however, that, if such publication contains any Confidential Information of Evotec, Evotec shall have the right to review and comment on any material proposed for such
publication or presentation by Novo, such as by oral presentation at scientific conferences or seminars, scientific journal manuscripts or abstracts. Before any such material is submitted for publication or presentation, Novo shall deliver a
complete copy of such material to Evotec at least forty-five (45) days prior to the proposed submission for publication or presentation and Evotec shall give its comments to Novo within thirty (30) days following delivery of such material.
With respect to oral presentation materials and abstracts, Evotec shall expedite review of such material and to provide comments (if any) to Novo within fifteen (15) working days following the date of delivery of such material to Evotec. Novo
shall (a) give due consideration to any editorial comments of Evotec, (b) comply with Evotec’s reasonable request to delete references to Evotec’s Confidential Information in any such material, and (c) delay any submission
for publication or presentation for a period of up to an additional ninety (90) days for the purpose of preparing and filing appropriate patent applications. Evotec staff that substantially contributed to the publication or presentation shall
be mentioned as the (co-)authors of such publication or presentation 

  
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	17.6	 Use of Names. Neither Party shall use the name of the other Party in relation to this transaction in any
public announcement, press release or other public document without the written consent of such other Party, which consent shall not be unreasonably withheld or delayed; provided, however, that either Party may use the name of the other Party in any
document filed with any Regulatory Authority or other authority to comply with legal or regulatory requirements, including the FDA, the EMA and the Securities and Exchange Commission. 

 

	18.	 REPRESENTATIONS AND WARRANTIES, LIMITATION OF LIABILITY 

 

	18.1	 Mutual Representations and Warranties. Each Party hereby represents and warrants to the other Party
that, as of the Effective Date: 

  

	 	18.1.1	 such Party (a) has the authority and right to enter into this Agreement and perform its obligations
hereunder, and (b) has taken all necessary corporate action on its part required to authorize the execution and delivery of this Agreement and the performance of its obligations hereunder; 

 

	 	18.1.2	 this Agreement has been duly executed and delivered on behalf of such Party and constitutes a legal, valid and
binding obligation of such Party and is enforceable against it in accordance with its terms subject to the effects of bankruptcy, insolvency or other mandatory laws of general application affecting the enforcement of creditor rights and judicial
principles affecting the availability of specific performance; 

  

	 	18.1.3	 to its knowledge, after internal inquiry into the relevant subject matter, as of the Effective Date, its
performance of the obligations that arise on its part out of this Agreement shall not involve any misappropriation or improper use of any properties or assets (including but not limited to any Know-How and/or
other Intellectual Property Rights) of a Third Party, 

  

	 	18.1.4	 it has full legal or beneficial title, ownership or Control to its Background IP, and to the best of its
knowledge it has the rights necessary to grant the licenses to the other Party in accordance with Section 10.1 and 10.2 respectively; and; 

  

	 	18.1.5	 it is self-insured or covered and will continue to be covered, and will require its Affiliates, to be
self-insured or covered at its own cost, by a comprehensive general liability insurance program (including product liability (if applicable), public liability and environmental liability) on terms customary in the pharmaceutical industry which is
adequate and sufficient to secure that Party’s obligations, and, as the case may be, obligations of its Affiliates, under this Agreement, at a coverage of at least 5,000,000 USD (Five Million US Dollars) per occurrence per year.

  
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	18.2	 Additional Representations and Warranties. 

 

	 	18.2.1	 Warranties of Evotec. Evotec hereby represents, warrants and covenants to Novo that as of the Effective
Date: 

  

	 	a)	 it has not granted, is not under any obligation to grant, and during the term of this Agreement will not grant,
any rights to any Third Party which would conflict with the rights granted to Novo hereunder; 

  

	 	b)	 there are no pending actions, suits, proceedings or claims by any Third Party, pending investigations or other
proceeding by any government authority, against Evotec that may adversely affect Evotec’s performance of its obligations under this Agreement; 

  

	 	c)	 Evotec shall be solely responsible for payment of, and shall fully and timely pay, any and all license fee,
maintenance fee, royalty, milestones, sublicensing revenue, assignment fee or similar payment obligations under any agreement between Evotec and a Third Party existing at the Effective Date which accrue with respect to the practice by Novo, its
Affiliates and Sublicensees of the Evotec Background IP and the Evotec Library Compounds licensed to Novo under this Agreement; 

  

	 	d)	 Evotec has, and will for the duration of the Collaboration Activities, not terminate the license agreements
enabling Evotec’s access to the SKS data and the NURTuRE Biobank; 

  

	 	e)	 to Evotec’s knowledge after reasonable inquiry into the relevant subject matter, the Evotec Background IP
is not subject to any restrictions, liens or encumbrances that would limit the rights to be granted to Novo under this Agreement; 

  

	 	f)	 Evotec is not aware that the practice of the Evotec Background IP in the performance of the Collaboration
Activities and use of the Hits in the performance of the Collaboration Activities will infringe any Patent Rights or other Intellectual Property Rights of Third Parties; 

 

	 	g)	 there have been no inventorship or ownership challenges with respect to any of the Evotec Background Patents;

  

	 	h)	 to Evotec’s knowledge, neither Evotec nor any of its Affiliates or their respective current or former
employees have misappropriated any of the Background Know-How from any Third Party relevant for the performance of the Collaboration Activities, and Evotec is not aware of any claim by a Third Party that such
misappropriation has occurred; 

  
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	 	i)	 to Evotec’s knowledge, after reasonable inquiry into the relevant subject matter, there are no actual,
pending, alleged or threatened adverse actions, suits, administrative proceedings, claims, re-examinations, oppositions, interferences or formal governmental investigations involving the Background IP relevant
for the performance of the Collaboration Activities by or against Evotec or any of its Affiliates in or before any court, governmental authority or Regulatory Authority; 

 

	 	j)	 Evotec has not been debarred and is not subject to any debarment and Evotec will not use in any capacity, in
connection with the Collaboration Activities to be performed under this Agreement, any person who has been debarred pursuant to section 306 of the United States Federal Food, Drug, and Cosmetic Act or similar provisions in other countries, or who is
the subject of a conviction described in such sections. Evotec agrees to inform Novo in writing immediately if it or any person who is performing services hereunder is debarred or is the subject of a conviction described in section 306 or
similar provisions in other countries, or if any action, suit, claim, investigation or legal or administrative proceeding is pending or, to Evotec’s or its Affiliates’ knowledge, is threatened, relating to the debarment or conviction of
Evotec or any person performing services hereunder. 

  

	 	18.2.2	 Warranty of Novo. Novo hereby represents and warrants to Evotec that, as of the Effective Date, Novo
after reasonable inquiry into the relevant subject matter, is not aware that the practice of the Novo Background IP in the performance of the Collaboration Activities will infringe any Patent Rights or other Intellectual Property Rights of Third
Parties. 

  

	 	18.2.3	 No Implied Warranties. EXCEPT FOR THE EXPRESS WARRANTIES SET FORTH IN SECTIONS 18.1 AND 18.2, NOVO AND
EVOTEC MAKE NO REPRESENTATIONS AND GRANT NO WARRANTIES, EXPRESS OR IMPLIED, EITHER IN FACT OR BY OPERATION OF LAW, BY STATUTE OR OTHERWISE, AND NOVO AND EVOTEC EACH SPECIFICALLY DISCLAIM ANY OTHER REPRESENTATIONS AND WARRANTIES, WHETHER WRITTEN OR
ORAL, EXPRESS, STATUTORY OR IMPLIED, INCLUDING ANY WARRANTY OF QUALITY, MERCHANTABILITY OR FITNESS FOR A PARTICULAR USE OR PURPOSE OR ANY WARRANTY AS TO THE VALIDITY OF ANY PATENTS OR THE NON-INFRINGEMENT OF
ANY INTELLECTUAL PROPERTY RIGHTS OF THIRD PARTIES. NOVO DISCLAIMS ANY REPRESENTATION OR WARRANTY THAT THE DEVELOPMENT, MANUFACTURE AND COMMERCIALIZATION OF LICENSED PRODUCT PURSUANT TO THIS AGREEMENT WILL BE SUCCESSFUL OR THAT, IF COMMERCIALIZED,
ANY PARTICULAR SALES LEVEL WILL BE ACHIEVED. 

  

	19.	 INDEMNIFICATION 

 

	19.1	 Indemnification by Novo. Novo shall indemnify, defend and hold harmless Evotec and Evotec’s
Affiliates, directors, officers, employees and agents from and against any and all suits, claims, actions, demands, liabilities, expenses and/or loss (jointly: “Losses”), including reasonable legal expenses and reasonable
attorneys’ fees arising 

  
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from claims made by Third Parties, which Losses result directly or indirectly from (a) any misrepresentation or breach of any warranty covenant or agreement made by Novo in this Agreement;
(b) Novo’s willful misconduct or gross negligence in the conduct of its activities under this Agreement; and (c) any infringement of any Third Party rights by the use of Intellectual Property Rights owned or Controlled by Novo; it
being understood that the indemnification referred to in this Section 19.1 shall not apply to the extent that Evotec is obligated to indemnity Novo pursuant to Section 19.2. 

 

	19.2	 Indemnification by Evotec. Evotec hereby agrees to indemnify, defend and hold harmless Novo and
Novo’s Affiliates, directors, officers, employees and agents from and against any and all Losses, including reasonable legal expenses and reasonable attorneys’ fees arising from claims made by Third Parties, which Losses result directly or
indirectly from (a) any misrepresentation or breach of any warranty covenant or agreement made by Evotec in this Agreement; (b) Evotec’s wilful misconduct or gross negligence in the conduct of its activities under this Agreement; and
(c) any infringement of any Third Party rights by the use of Novo of the Intellectual Property Rights owned or Controlled by Evotec in the performance of the Collaboration Activities; it being understood that the indemnification referred to in
this Section 19.2 shall not apply to the extent that Novo is obligated to indemnify Evotec pursuant to Section 19.1. 

  

	19.3	 Procedure. The Indemnified Party shall, if the Indemnifying Party acknowledges that such Claim falls
within the scope of its indemnification obligations hereunder, permit the Indemnifying Party to assume direction and control of the defence, litigation, settlement, appeal or other disposition of the claim (including the right to settle the claim
solely for monetary consideration); provided, that the Indemnifying Party shall seek the prior written consent (not to be unreasonably withheld or delayed) of Indemnified Party as to any settlement which would diminish or materially adversely affect
the scope, exclusivity or duration of any Patent Rights licensed under this Agreement, would require any payment by the Indemnified Party, would require an admission of legal wrongdoing in any way on the part of the Indemnified Party, or would
effect an amendment of this Agreement. Provided that an Indemnified Party has complied with the foregoing, the Indemnifying Party shall provide attorneys reasonably acceptable to the Indemnified Party to defend against any such claim. Subject to the
foregoing, an Indemnified Party may participate in any proceedings involving such claim using attorneys of its choice and at its expense. In no event may an Indemnified Party settle or compromise any claim for which it intends to seek
indemnification from the Indemnifying Party hereunder without the prior written consent (such consent not to be unreasonably withheld or delayed) of the Indemnifying Party, or the indemnification provided under this Section 19.3 as to such
claim shall be null and void. The reasonable legal expenses and reasonable attorneys’ fees arising from claims made by Third Parties incurred by the Indemnified Party in connection with any Loss, shall be reimbursed on a Calendar Quarterly
basis by the Indemnifying Party, without prejudice to the Indemnifying Party’s right to contest the Indemnified Party’s right to indemnification and subject to refund in the event the Indemnifying Party is ultimately held not to be
obligated to indemnify the Indemnified Party for such Loss. 

  
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	19.4	 Obligation to Co-Operate. Whether or not the Indemnifying
Party chooses to defend or prosecute any claim involving a Third Party, each Party to this Agreement and their Affiliates shall cooperate in the defence or prosecution thereof, including by providing access to and copies of pertinent records and
making available for testimony relevant individuals (subject to its control), as reasonably requested by, and at the expense of, the Indemnifying Party. 

  

	19.5	 Other Indemnified Persons. For the purposes of this Section 19, the indemnification of the
Indemnified Party shall also include the indemnification of the Indemnified Party’s directors, officers, employees, Affiliates, agents and Third Parties performing services for the Indemnified Party. 

 

	19.6	 Limitation of Liability. EXCEPT FOR LIABILITY FOR BREACH OF SECTION 17 (CONFIDENTIALITY AND
PUBLICATION) AND WITHOUT PREJUDICE TO THE OBLIGATION OF EITHER PARTY TO INDEMNIFY THE OTHER IN RESPECT OF CLAIMS BY A THIRD PARTY UNDER SECTION 19.1 or 19.2, NEITHER PARTY SHALL BE ENTITLED TO RECOVER FROM THE OTHER PARTY ANY SPECIAL, INCIDENTAL,
CONSEQUENTIAL, PUNITIVE OR OTHER INDIRECT DAMAGES IN CONNECTION WITH THIS AGREEMENT OR ANY LICENSE GRANTED HEREUNDER; PROVIDED, HOWEVER THAT THIS SECTION 19.6 SHALL NOT BE CONSTRUED TO LIMIT DAMAGES AWARDED SPECIFICALLY IN RESPECT OF EITHER
PARTY’S GROSS NEGLIGENCE OR WILLFULLY WRONGFUL CONDUCT. 

  

	20.	 TERM AND TERMINATION 

 

	20.1	 Collaboration Term. The Collaboration Term shall commence on the Effective Date and, unless sooner
terminated as provided herein, shall continue in force for a term of six (6) years unless earlier termination or expiry of this Agreement by a Party under this Section 20 (the “Collaboration Term”). 

 

	20.2	 Term of the Agreement. The term of this Agreement shall commence on the Effective Date and continue
until expiration, on a Product-by-Product basis, of the last-to-expire Royalty Term for
such Product, unless earlier terminated as provided for in this Section 20. Upon the expiration of the Royalty Term with respect to a Product in a country, Novo shall have a fully-paid-up perpetual
license under Section 10.1 to research, develop, make, use, manufacture, register, offer for sale, sell, have sold, import and export, distribute, and market Product in such country. 

 

	20.3	 Termination of a Project or the Agreement by Novo without Cause. During the term of this
Agreement, Novo is entitled (i) to terminate a Project at any time without cause by giving three (3) months prior written notice but no more than one (1) Project per calendar month, and (ii) to terminate this Agreement at
any time without cause by giving six (6) months prior written notice. The Parties agree that the Project objectives as 

  
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defined in the individual Projects are target objectives. The Parties’ ability to fulfil these objectives is, inter alia, at least in part dependent on technical parameters defined from time
to time. Evotec and Novo agree that any failure to meet the defined Project objectives shall not be deemed a material breach by either Party of its obligations under the Projects, provided that both Parties use Commercially Reasonable Efforts to
fulfill the Project objectives, including each Party’s adherence to the expressed and mutually agreed Project Plans. Termination of a specific Project will be effective only as to such specific Project, as the case may be, and shall not affect
the validity of this Agreement or the continuation of other Projects; unless the breach is of a general nature and also impacts other Projects. In such case, either Party may have the right to terminate this Agreement pursuant to Section 20.4.

  

	20.4	 Termination of a Project or Agreement by either Party for Cause. Notwithstanding the stipulation in
Section 20.2 hereof, if either Party commits a material breach of its obligations under a Project or under this Agreement, the non-breaching Party may notify the breaching Party in writing specifying the
nature of breach in reasonable detail and calling the breaching Party to cure such breach. If the breaching Party fails to remedy such breach within (a) forty-five (45) days in case of a payment due under this Agreement or (b) ninety
(90) days in case of any other breach (or, if the breach cannot reasonably be remedied within remedy periods, failure by the other Party to make good faith efforts diligently to pursue completion of remedy) upon receipt of the foregoing notice from
the non-breaching Party, the non-breaching Party may terminate the relevant Project or the Agreement (whichever is relevant) with immediate effect upon further written
notice to the breaching Party. 

  

	20.5	 Termination by either Party for Bankruptcy. Notwithstanding the stipulation in this Section 20, a
Party shall be entitled to terminate this Agreement with immediate effect if the other Party files in any court or agency pursuant to any statute or regulation pertaining to bankruptcy, solvency, or payment of debts, of any state or country, a
petition in bankruptcy or insolvency or for reorganisation or for an arrangement or for the appointment of a receiver or trustee of such Party or of its assets, or if the other Party proposes a written agreement of composition or extension of its
debts, or if the other Party shall be served with an involuntary petition against it, filed in any insolvency proceeding, and such petition shall not be dismissed within sixty (60) days after the filing thereof, or if the other Party shall
propose or be a party to any dissolution or liquidation, or if the other Party shall make an assignment for the benefit of creditors. 

  

	21.	 EFFECTS OF TERMINATION 

 

	21.1	 General Effects of Termination. 

 

	 	a)	 Accrued Obligations. Termination or expiry of this Agreement for any reason shall not release any Party
hereto from any liability which, at the time of such termination, has already accrued to the other Party nor preclude either Party from pursuing all rights and remedies it may have. 

  
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	 	b)	 Transition Plan and Minimization of Costs. Upon termination of this Agreement or an individual Project
by Evotec or Novo for any reason, the Parties shall, in good faith, work out a transition plan to secure an orderly wind-down of their respective Collaboration Activities, return the relevant Materials to each other, complete and deliver required
reports and accountings, and settle any other outstanding issues. Evotec shall use best efforts to minimize the costs related to such wind-down to Novo. 

  

	 	c)	 Return of Information. Each Party shall promptly return or destroy upon the written request of the other
Party either all or, in case an individual Project is terminated, the Project-specific Confidential Information and Materials of the other Party that are not subject to a continuing license or continuing other rights and obligations hereunder;
provided, that each Party may retain one copy of the Confidential Information of the other Party in its archives solely for the purpose of establishing the contents thereof and ensuring compliance with its obligations hereunder.

  

	 	d)	 In addition to the general provisions of this Sections 21.1 and 21.10 (Survival), the provisions of the
following Sections 21.2 through 21.9 shall apply in the specific circumstances referenced therein. 

  

	21.2	 Effects of Novo’s Termination of a Project without Cause pursuant to
Section 20.3. If Novo, on the basis of Section 20.3, without cause, during the Collaboration Term terminates a Project, the following shall apply as of the effective date of termination: 

 

	 	a)	 The license granted to Evotec under Section 10.2 shall terminate with respect to the terminated Project;

  

	 	b)	 Novo shall continue to have the right, but not the obligation, to further develop and Commercialize the
Compound(s) of the terminated Project, in which case any payment obligations of Novo to Evotec set forth under Section 14 shall remain in effect with respect to such Compound(s). In deviation of Section 14.2.1, if, after termination of a
Project, Novo continues the development of a Compound of such Project, the PDC Approval Milestone shall become payable; 

  

	 	c)	 If the Compound of the terminated Project is a Small Molecule Compound, and unless such Compound has progressed
to a Product, Evotec shall have the right, but not the obligation, to present a commercial proposal to Novo for the in-licensing of such Compound and pertaining Compound Patents. Novo shall give such proposal
due consideration. Any decision as to whether to enter into a license agreement with Evotec as well as the terms of such license will be at Novo’s sole discretion; 

  
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	 	d)	 All other rights and obligations set forth in this Agreement shall remain in effect if and for as long as Novo
uses Commercially Reasonable Efforts to develop and Commercialize a Product that includes or consists of a PDC with a Compound that modulates a Project Target, including for clarity, Evotec’s Target Exclusivity obligations under
Section 5.3 and the licenses granted under 10.1 to 10.3 in respect of the Project Target of the terminated Project. Novo will provide Evotec with annual reports with respect to any such development and Commercialization, containing a high-level
overview of Novo’s activities and any upcoming milestone payments, royalty payments or other payments. 

  

	21.3	 Effects of Novo’s Termination of the Agreement without Cause pursuant to
Section 20.3. If Novo, on the basis of Section 20.3, terminates the Agreement without cause, the following will apply as of the effective date of termination: 

 

	 	a)	 The license granted to Evotec under Section 10.2 shall terminate; 

 

	 	b)	 Novo shall continue to have the right, but not the obligation, to further research, develop and Commercialize
the Compound(s), in which case any payment obligations of Novo to Evotec set forth under Section 14 shall remain in effect with respect to such Compound(s). In deviation of Section 14.2.1, if, after termination of a Project, Novo continues
the development of a Compound of such Project the PDC Approval Milestone shall become payable; 

  

	 	c)	 Evotec’s Target Exclusivity obligations under Section 5.3 shall remain in effect in respect of any
Target if and for as long as Novo uses Commercially Reasonable Efforts to develop and Commercialize a Product that includes or consists of a PDC with a Compound that modulates such Target. Novo will provide Evotec with annual reports with respect to
any such development and Commercialization, containing a high-level overview of Novo’s activities and any upcoming milestone payments, royalty payments or other payments; 

 

	 	d)	 If a Compound is a Small Molecule Compound and unless such Compound has progressed to a Product, Evotec shall
have the right, but not the obligation, to present a commercial proposal to Novo for the in-licensing of the Compound and pertaining Compound Patents. Novo shall give such proposal due consideration. Any
decision as to whether to enter into a license agreement with Evotec, as well as the terms of such license, will be at Novo’s sole discretion; 

  

	 	e)	 Subject to Sections 21.1 and 21.10, all other rights and obligations set forth in this Agreement shall
terminate. 

  

	21.4	 Effects of Novo’s Termination of a Project for Cause pursuant to
Section 20.4. If Novo, for cause, terminates one or more Projects pursuant to Section 20.4 (breach by Evotec), the following shall apply as of the effective date of termination of such Project: 

 

	 	a)	 The license granted to Evotec under Section 10.2 shall terminate with respect to the terminated Project;

  
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	 	b)	 Novo shall continue to have the right, but not the obligation, to further research, develop and Commercialize
the Compound(s) of the terminated Project. In deviation of Section 14.2.1, if, after termination of a Project, Novo continues the development of a Compound of such Project the PDC Approval Milestone shall become payable. Any payment obligations
of Novo to Evotec set forth under Sections 14.2.1, 14.2.2, 14.2.4 and 14.4 shall be reduced by fifty percent (50%) with respect to such Compounds and Products. 

 

	 	c)	 All other rights and obligations set forth in this Agreement shall remain in effect if and for as long as Novo
uses Commercially Reasonable Efforts to develop and Commercialize a Product that includes or consists of a PDC with a Compound that modulates a Project Target, including for clarity, Evotec’s Target Exclusivity obligations under
Section 5.3 and the licenses granted under 10.1 to 10.3 in respect of the Project Target of the terminated Project. Novo will provide Evotec with annual reports with respect to any such development and Commercialization, containing a high-level
overview of Novo’s activities and any upcoming milestone payments, royalty payments or other payments. 

  

	21.5	 Effects of Novo’s Termination of the Agreement for Cause pursuant to
Section 20.4. If Novo, for cause, terminates the Agreement pursuant to Section 20.4 (breach by Evotec), the following shall apply as of the effective date of termination of the Agreement: 

 

	 	a)	 Novo shall have the right, but not the obligation, to further research, develop and Commercialize Compounds and
Products; 

  

	 	b)	 The licenses granted to Novo under Section 10.1 shall remain in effect with respect to such Compounds and
Products. 

  

	 	c)	 Provided that, prior to the breach by Evotec, at least one Compound had reached PDC approval, any payment
obligations of Novo to Evotec set forth under Sections 14.2.1, 14.2.2, 14.2.4 and 14.4 shall be reduced by fifty percent (50%) with respect to such Compounds and Products. 

 

	 	d)	 Evotec’s Target Exclusivity obligations under Section 5.3 shall remain in effect in respect of any
Target if and for as long as Novo uses Commercially Reasonable Efforts to develop and Commercialize a Product that includes or consists of a PDC with a Compound that modulates such Target. Novo will provide Evotec with annual reports with respect to
any such development and Commercialization, containing a high-level overview of Novo’s activities and any upcoming milestone payments, royalty payments or other payments; 

 

	 	e)	 Subject to Sections 21.1 and 21.10, all other rights and obligations set forth in this Agreement shall
terminate. 

  

	21.6	 Effects of Evotec’s Termination of a Project for Cause pursuant to Section 20.4.
If one or more Project(s) are terminated by Evotec for cause pursuant to Section 20.4 (breach by Novo), the following shall apply as of the effective date of termination of the Project: 

 

	 	a)	 Evotec’s Target Exclusivity obligations set forth in Section 5.3 shall terminate with respect to the
relevant Project Target; 

  
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	 	b)	 In deviation of Section 14.2.1, if Novo decides to continue the development of a Compound of the
terminated Project, which Compound had not yet reached PDC approval, the PDC Approval Milestone shall become payable for such Compound; 

  

	 	c)	 The license granted by Novo to Evotec under Section 10.2 shall terminate in respect of the terminated
Project; 

  

	 	d)	 If the Compound of the terminated Project is a Small Molecule Compound, and unless such Compound has progressed
to a Product, Evotec shall have the right, but not the obligation, to present a commercial proposal to Novo for the in-licensing of the Compound and pertaining Compound Patents. Novo shall give such proposal
due consideration. Any decision as to whether to enter into a license agreement with Evotec as well as the terms of such license will be at Novo’s sole discretion; 

 

	 	e)	 All other rights and obligations set forth in this Agreement shall remain in effect if and for as long as Novo
uses Commercially Reasonable Efforts to develop and Commercialize a Product that includes or consists of a PDC with a Compound that modulates a Project Target, including for clarity, the licenses granted under 10.1 to 10.3 in respect of the Project
Target of the terminated Project. Novo will provide Evotec with annual reports with respect to any such development and Commercialization, containing a high-level overview of Novo’s activities and any upcoming milestone payments, royalty
payments or other payments. 

  

	21.7	 Effects of Evotec’s Termination of the Agreement for Cause pursuant to Section 20.4.
If the Agreement is terminated by Evotec for cause pursuant to Section 20.4 (breach by Novo), the following shall apply as of the effective date of termination of the Agreement: 

 

	 	a)	 If a Compound is a Small Molecule Compound, and unless such Compound has progressed to a Product, Evotec shall
have the right, but not the obligation, to present a commercial proposal to Novo for the in-licensing of the Compound and pertaining Compound Patents. Novo shall give such proposal due consideration. Any
decision as to whether to enter into a license agreement with Evotec as well as the terms of such license will be at Novo’s sole discretion. 

  

	 	b)	 Novo shall not continue to have the right to further research, develop and Commercialize the Compound(s) and
Product(s) and, subject to Sections 21.1 and 21.10, all other rights and obligations set forth in this Agreement shall terminate. 

  
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	21.8	 Effects of Novo’s Termination of the Agreement pursuant to Section 20.5 or
Section 22.2. If this Agreement is terminated by Novo pursuant to Section 20.5 (bankruptcy of Evotec) or Section 22.2 (Change of Control of Evotec) the following shall apply: 

 

	 	a)	 Novo shall have the right, but not the obligation, to further research, develop and Commercialize Compounds and
Products; 

  

	 	b)	 The licenses granted to Novo under Section 10.1 shall remain in effect with respect to such Compounds and
Products; 

  

	 	c)	 Provided that, prior to the breach by Evotec, at least one Compound had reached PDC approval, any payment
obligations of Novo to Evotec set forth under Sections 14.2.1, 14.2.2, 14.2.4 and 14.4 shall be reduced by fifty percent (50%) with respect to such Compounds and Products. 

 

	 	d)	 Evotec’s Target Exclusivity obligations under Section 5.3 shall remain in effect in respect of any
Target if and for as long as Novo develops and Commercializes a Product that includes or consists of a PDC with a Compound that modulates such Target. Novo will provide Evotec with annual reports with respect to any such development and
Commercialization, containing a high-level overview of Novo’s activities and any upcoming milestone payments, royalty payments or other payments; 

  

	 	e)	 Subject to Sections 21.1 and 21.10, all other rights and obligations set forth in this Agreement shall
terminate. 

  

	21.9	 Effects of Termination of the Agreement by either Party pursuant to Section 22.11 (Force
Majeure). If the Agreement is terminated by either Party pursuant to Section 22.11 (Force Majeure) the following shall apply as of the date of termination: 

 

	 	a)	 Th Novo shall have the right, but not the obligation, to further research, develop and Commercialize Compounds
and Products; 

  

	 	b)	 The licenses granted to Novo under Section 10.1 shall remain in effect with respect to such Compounds and
Products. 

  

	 	c)	 Provided that, prior to the breach by Evotec, at least one Compound had reached PDC approval, any payment
obligations of Novo to Evotec set forth under Sections 14.2.1, 14.2.2, 14.2.4 and 14.4 shall be reduced by fifty percent (50%) with respect to such Compounds and Products. 

 

	 	d)	 Evotec’s Target Exclusivity obligations under Section 5.3 shall remain in effect in respect of any
Target if and for as long as Novo uses Commercially Reasonable Efforts to develop and Commercialize a Product that includes or consists of a PDC with a Compound that binds with such Target. Novo will provide Evotec with annual reports with respect
to any such development and Commercialization, containing a high-level overview of Novo’s activities and any upcoming milestone payments, royalty payments or other payments; 

 

	 	e)	 Subject to Sections 21.1 and 21.10, all other rights and obligations set forth in this Agreement shall
terminate. 

  
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	21.10	 Survival. The rights and obligations set forth in this Agreement shall extend beyond the term or
termination of this Agreement only to the extent expressly provided for herein, or to the extent that the survival of such rights or obligations are necessary to permit their complete fulfilment or discharge. Except where expressly provided for
otherwise in this Agreement, termination or expiration of this Agreement shall not relieve the Parties hereto of any liability, including any obligation to make payments hereunder, which accrued prior to the effective date of such termination or
expiration, nor preclude either Party from pursuing all rights and remedies it may have hereunder or at law or in equity with respect to any breach of this Agreement nor prejudice any Party’s right to obtain performance of any obligation.

  

	21.11	 The following provisions shall survive termination or expiry of this Agreement: Sections 1, 3.3, 5.1 (insofar
not expired prior to the date of termination or expiry of this Agreement), 8, 9, 10.1.2, 10.3, 10.4, 11.1, 12, 13, 14.1.4, 14.3, 15, 16, 17, 19, 22.3, 22.4, 22.7, 22.9 through 22.15. 

 

	22.	 MISCELLANEOUS 

 

	22.1	 Entire Agreement. The Parties hereto acknowledge that this Agreement, together with the Annexes attached
hereto, set forth the entire agreement and understanding of the Parties hereto as to the subject matter hereof, and supersedes all prior and contemporaneous discussions, agreements and writings in respect hereto, with exception of the
Confidentiality Agreement between the Parties dated 1 January 2018, which shall remain effective and binding with respect to confidential information exchanged between the Parties prior to the Effective Date. Each Party confirms that it is not
relying on any representations, warranties or covenants of the other Party except as specifically set out in this Agreement. Nothing in this Agreement shall operate to limit or exclude any liability for fraud. All Annexes referred to in this
Agreement are intended to be and are hereby specifically incorporated into and made a part of this Agreement. In the event of any inconsistency between any such Annexes and this Agreement, the terms of this Agreement shall govern

  

	22.2	 Change of Control in Evotec. In the event that ownership of or control over fifty per cent (50 %) of the
voting stock of Evotec is acquired directly or indirectly by any person, company corporation or other business entity which is a competitor of Novo then Novo shall have the right, at its sole discretion, to take one or more of the following actions:
(i) terminate this Agreement, or (ii) require Evotec and the change of control party to adopt reasonable procedures to prevent disclosure of Novo’s Confidential Information, and (iii) suspend indefinitely all of its reporting
obligations to Evotec except for Net Sales and royalty numbers and information necessary to verify Novo is meeting its diligence obligations. For the purposes of this Section 22.2, ‘competitor’ means any Third Party which is actively
researching and/or developing and/or commercializing products in at least one indication area in which Novo is also active. 

  
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	22.3	 Governing Law. This Agreement and any dispute arising therefrom shall be governed by and construed in
accordance with the laws of England and Wales , regardless of the conflict of laws principles of that or any other jurisdiction. The UN Convention on Contracts for the International Sale of Goods is not applicable to this Agreement.

  

	22.4	 Dispute Resolution. 

 

	 	22.4.1	 Mutual Dispute Resolution. If a dispute arises between the Parties relating to the validity,
interpretation, breach or enforcement of this Agreement, the Parties shall use the following non-binding procedure in good faith prior to either Party pursuing arbitration remedies. Each Party shall notify the
other Party of the dispute in accordance with Section 22.10. The Parties shall use good faith efforts to resolve such dispute within thirty (30) days after delivery of such notice, which good faith efforts shall include at least one (1) in-person meeting between representatives of each Party having decision-making authority (subject only to Board of Directors’ or equivalent approval, if required), unless the enforcement of its rights
requires speedier measures by the effected Party. All such discussions shall be confidential and shall be treated as compromise and settlement negotiations for purposes of applicable rules of evidence. 

 

	 	22.4.2	 Arbitration. If a dispute is not resolved as provided in Section 22.4.1, whether before or after
expiration or termination of this Agreement, the Parties hereby agree that such dispute will be resolved by final and binding arbitration conducted in accordance with the Rules of Arbitration of the International Chamber of Commerce by one or more
arbitrators appointed in accordance with the said Rules with significant experience in the pharmaceutical manufacturing industry. The Emergency Arbitrator Provisions shall not apply. The Parties agree that they shall have no right to seek production
of documents or any other discovery in the arbitration proceeding, except that the parties shall exchange the documents that they intend to use in evidence at the hearing. The arbitrators will be instructed not to award any punitive or special
damages. The arbitration shall take place in London, UK, and shall be conducted in the English language. The award of the arbitrators shall be final and binding on the Parties. The Parties bind themselves to carry out the awards of the arbitrators.
The governing law of this Agreement will govern any such proceedings. By entering into this agreement to arbitrate, the Parties expressly waive any claim for punitive or exemplary damages. Each Party will pay its legal fees and costs related to the
arbitration (including witness and expert fees). Judgment on the award so rendered will be final and may be entered in any court having jurisdiction thereof. 

  

	 	22.4.3	 Nothing in this Section 22.4 will preclude either Party from seeking equitable relief or interim or
provisional relief from a court of competent jurisdiction, including a temporary restraining order, preliminary injunction, specific performance or other interim equitable relief, concerning a dispute either prior to or during any arbitration if
necessary to protect the interests of such Party or to preserve the status quo pending the arbitration proceeding. 

  
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	22.5	 Modification, Waiver. This Agreement may not be altered, amended or modified in any way except by a
written agreement signed by both Parties. The failure of a Party to enforce any rights or provisions of the Agreement shall not be construed to be a waiver of such rights or provisions, or a waiver by such Party to thereafter enforce such rights or
provision or any other rights or provisions hereunder. No waiver shall be effective unless made in writing and signed by the waiving Party. 

  

	22.6	 Assignment. Either Party may assign, without consent, any of its rights or obligations under this
Agreement to any of its Affiliates, provided, however, that such assignment shall not relieve the assigning Party of its responsibilities for performance of its obligations under this Agreement. Either Party may transfer or assign its rights and
obligations under this Agreement, in case of Novo without consent and in case of Evotec only upon Novo’s written approval. This Agreement shall be binding upon and inure to the benefit of successors and permitted assigns of the Parties. Any
purported assignment not in accordance with this Agreement shall be null and void and of no legal effect 

  

	22.7	 Public Announcements. Subject to Section 17.2, neither Party shall make any public announcement or
communication in connection with the existence of this Agreement or its terms without the prior written consent of the other Party, which may be withheld without any reason being given. 

 

	22.8	 Press Release. Notwithstanding the provisions of Section 17, Evotec may upon the Effective Date
issue one press release in its name only announcing the signing of this Agreement. Such press release, and any Q&A, of Evotec shall require the prior written approval of Novo. Novo may agree, at its discretion, to issue a joint press release
with Evotec at the Effective Date or as otherwise agreed between the Parties. No other press release shall be issued relating to this Agreement. 

  

	22.9	 Relationship of the Parties. It is expressly agreed that the relationship between the Parties is and
will be that of independent contractors, and that the relationship between the Parties will not constitute a partnership, joint venture or agency. Neither Party will have the authority to make any statements, representations or commitments of
any kind, or to take any actions, which are binding on the other Party, except with the prior written consent of the other Party to do so. All persons employed by a Party will be employees of such Party and not of the other Party and all costs and
obligations incurred by reason of any such employment will be for the account and expense of such Party. 

  
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	22.10	 Notices. Any notice, report, communication or consent required or permitted by this Agreement shall be
in writing and shall be (a) delivered personally, (b) sent by e-mail or facsimile (and promptly confirmed by personal delivery or overnight courier as provided in this Agreement), or (c) sent by
internationally-recognized overnight courier addressed to the other Party at the address shown below or at such other address for which such Party gives notice hereunder: If to Evotec: Evotec International GmbH Dr Cord Dohrmann, CSO Essener Bogen 7
22419 Hamburg With a copy to: 

  

			
	If to Evotec:	  	Evotec International GmbH
		  	[***] CSO
		  	Essener Bogen 7
		  	22419 Hamburg
		
	With a copy to:	  	Evotec SE
		  	Head of Legal
		  	Essener Bogen 7
		  	22419 Hamburg
		
	And a copy to:	  	 [***]

		
	If to Novo:	  	Novo Nordisk A/S
		  	Novo Allé
		  	2880 Bagsværd
		  	Denmark
		  	Attention: Head of Business Development
		
	With a copy to:        	  	General Counsel
		
		  	 [***]

		
	And a copy to:	  	Novo Nordisk A/S
		  	Vandtårnsvej 112
		  	DK-2860 Søborg
		  	Denmark
		  	Attention: Head of Alliance Management

  

	22.11	 Force Majeure. 

 

	 	22.11.1	 Other than an event or circumstance that results in a Party’s not having sufficient funds to comply with
an obligation to pay money, neither Party shall be held responsible for any delay or failure in performance hereunder caused by strikes, embargoes, unexpected government requirements, civil or military authorities, acts of God, earthquake, war,
riot, civil commotion, terrorist act, malicious damage, epidemic, quarantine, fire, flood, storm, natural disaster or by the public enemy or other causes reasonably beyond such Party’s control and without such Party’s fault or negligence;
provided that the affected Party promptly notifies the unaffected Party in writing claiming force majeure and uses its best efforts to eliminate the effect of force majeure insofar as is possible and with all reasonable dispatch. The Party suffering
the force majeure event shall not be liable for delay in performance or for non-performance of its obligations under this Agreement, in whole or in part, nor

  
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	EXECUTION VERSION	  	8 July 2020

  

	 	
shall the other Party have the right to terminate this Agreement, except as otherwise provided in this Agreement, where non-performance or delay in
performance has resulted from a force majeure event. If the period of delay or failure should extend for more than three (3) months then either Party shall have the right to terminate this Agreement forthwith upon written notice at any time
after expiration of said three (3) months period. 

  

	 	22.11.2	 If a Party is prevented from performing its obligations due to a force majeure event for a continuous period in
excess of sixty (60) Business Days after the date of the occurrence of the force majeure event, and such failure to perform would constitute a material breach of this Agreement in the absence of such force majeure event, the Parties shall meet
and discuss in good faith any amendments to this Agreement to permit the other Party to exercise its rights under this Agreement. If the Parties are not able to agree on such amendments within sixty (60) Business Days and if the suspension of
performance continues, such other Party may terminate this Agreement immediately by written notice to the Party suffering the force majeure event, in which case neither Party shall have any liability to the other except for (a) the termination
rights set forth in Section 20 and (b) those rights and liabilities that accrued prior to the date of termination. 

  

	22.12	 Severability. To the fullest extent permitted by applicable law, if any provision hereof is or later
becomes invalid, illegal or unenforceable, such provision shall be ineffective without affecting the validity of the remaining provisions, unless the invalid or illegal provision is of such essential importance to this Agreement that it cannot
reasonably be assumed that the Parties would have concluded this Agreement in its absence. The Parties shall attempt to replace the invalid, illegal or unenforceable provision with valid, legal and enforceable provision as closely aligned with the
original intent of the Parties as possible. 

  

	22.13	 Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed
an original and all of which together shall constitute one instrument. 

  

	22.14	 Expenses. Except as otherwise expressly provided in this Agreement, each Party shall pay the fees and
expenses of its respective lawyers and other experts and all other expenses and costs incurred by such Party incidental to the negotiation, preparation, execution and delivery of this Agreement. 

 

	22.15	 No Third Party Beneficiaries. No person, other than Novo, Evotec, their Affiliates and their permitted
assignees hereunder, shall be deemed an intended beneficiary hereunder or have any right to enforce any obligation of this Agreement. 

[signatures page follows] 

  
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 IN WITNESS WHEREOF, Evotec and Novo have executed this Agreement by their duly authorized representatives.

  

					
	Novo Nordisk A/S	 		  	Evotec International GmbH
			
	Date: __July 2020	 	        	  	Date: __July 2020
			
	Signature:	 		  	Signature:
			
	 	 		  	 
			
	 [***]
	 		  	Name: [***]
			
	Executive Vice President	 		  	Title: EVP Global Head of Finance

  
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