Document:

Exhibit 4.19

 

 

1.5% SENIOR CONVERTIBLE NOTE

 

RS-10March 21, 2016

 

U.S. $3,700,000

 

THE SECURITIES REPRESENTED BY THIS NOTE AND THE SECURITIES ISSUABLE
UPON ITS CONVERSION HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR SECURITIES
LAWS OF ANY STATE AND MAY NOT BE OFFERED, SOLD, ASSIGNED, PLEDGED TRANSFERRED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF AN EFFECTIVE
REGISTRATION STATEMENT UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN AVAILABLE EXEMPTION FROM REGISTRATION
UNDER THE ACT OR SUCH LAWS AND, IF REASONABLY REQUESTED BY THE COMPANY, UPON DELIVERY OF AN OPINION OF COUNSEL REASONABLY SATISFACTORY
TO THE COMPANY THAT THE PROPOSED TRANSFER IS EXEMPT FROM THE ACT OR SUCH LAWS. THIS NOTE IS ALSO SUBJECT TO THE TRANSFER RESTRICTIONS
CONTAINED IN THE SECURITIES PURCHASE AGREEMENT, DATED AS OF JULY 30, 2012, AMONG THE COMPANY AND TOTAL ENERGIES NOUVELLES ACTIVITÉS
USA (FORMERLY KNOWN AS TOTAL GAS & POWER USA, SAS).

 

FOR VALUE RECEIVED, the undersigned, Amyris,
Inc., a Delaware corporation (the “Company”), promises to pay to Total Energies Nouvelles Activités
USA (formerly known as Total Gas & Power USA, SAS), a société par actions simplifiée organized
under the laws of the Republic of France, or its Permitted Transferees pursuant to Section 13 of this Note (the “Investor”),
in lawful money of the United States and in immediately available funds (or in shares of Common Stock as provided herein), U.S.
$3,700,000 (the “Face Amount”), all in accordance with the provisions of this Note. The “Issue
Date” of this Note is March 21, 2016.

 

This Note was issued pursuant to the Securities
Purchase Agreement, dated as of July 30, 2012 (as amended from time to time, the “Agreement”), among
the Company and the Investor. As used herein, “Note” means this 1.5% Senior Convertible Note issued to
the Investor pursuant to the Agreement. This Note is issued in exchange for convertible note RS-9 originally issued on July 29,
2015, which was issued in exchange for convertible note RS-2 originally issued on December 2, 2013, which was issued in exchange
for convertible note R-4 originally issued on June 6, 2013 (the “Original Issue Date”) pursuant to the
Agreement.

 

1.                 
Definitions. For purposes of this Note, the following definitions shall be applicable:

 

“Affiliate” of any
specified person means any other person directly or indirectly controlling or controlled by or under direct or indirect common
control with such specified person; for purposes of this definition, “control” (including, with correlative meanings,
the terms “controlling,” “controlled by” and ‘under common control with”), as used with respect
to any person, shall mean the possession, directly or indirectly, of the power to direct or cause the

     

     

    

 

direction of the management or policies of such
person, whether through the ownership of voting securities, by agreement or otherwise.

 

“Bankruptcy Law” means Title 11, U.S.
Code or any similar federal or state law for the relief of debtors.

 

“Board of Directors” means
the board of directors of the Company.

 

“Business Day” means any day other than
a Saturday, a Sunday or a day on which the Federal Reserve Bank of New York is authorized or required by law or executive order
to close or be closed.

 

“Capital Lease Obligation”
means, at the time any determination thereof is to be made, the amount of the liability in respect of a capital lease that would
at such time be required to be capitalized on a balance sheet in accordance with GAAP.

 

“Certificate of Incorporation”
means the Company’s Restated Certificate of Incorporation, as amended and as in effect on the date hereof.

 

“Change of Control”
shall mean the occurrence of any of the following: (i) the consolidation of the Company with, or the merger of the Company
with or into, another “person” (as such term is used in Rule 13d-3 and Rule 13d-5 of the Exchange Act), or the sale,
lease, transfer, conveyance or other disposition, in one or a series of related transactions, of all or substantially all of the
assets of the Company and its Subsidiaries taken as a whole, or the consolidation of another “person” with, or the
merger of another “person” into, the Company, other than in each case pursuant to a transaction in which the “persons”
that “beneficially owned” (as such term is defined in Rule 13d-3 and Rule 13d-5 under the Exchange Act), directly or
indirectly, the Voting Shares of the Company immediately prior to the transaction “beneficially own”, directly or indirectly,
Voting Shares representing at least a majority of the total voting power of all outstanding classes of voting stock of the surviving
or transferee person; (ii) the adoption by the Company of a plan relating to the liquidation or dissolution of the Company;
(iii) the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which
is that any “person” becomes the “beneficial owner” directly or indirectly, of more than 50% of the Voting
Shares of the Company (measured by voting power rather than number of shares); or (iv) the first day on which a majority of
the members of the Board of Directors does not consist of Continuing Directors.

 

“Closing Price” of
the shares of Common Stock on any day means the last reported sale price regular way on such day or, in the case no such sale takes
place on such day, the average of the reported closing bid and asked prices regular way of the shares of Common Stock, in each
case as quoted on The NASDAQ Stock Market or such other principal securities exchange or inter-dealer quotation system on which
the shares of Common Stock are then traded.

 

“Common Stock” means
the Company’s common stock, $0.0001 par value per share (or such other security into which such Common Stock is exchanged
for (or becomes) pursuant to the consummation of a Capital Reorganization (as defined in Section 3(g))).

 

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“Continuing Director”
shall mean, as of any date of determination, any member of the Board of Directors who (i) was a member of the Board of Directors
on July 31, 2012 or (ii) was nominated for election or elected to the Board of Directors with the approval of a majority of
the Continuing Directors who were members of the Board of Directors at the time of such nomination or election and who voted with
respect to such nomination or election; provided that a majority of the members of the Board of Directors voting with respect thereto
shall at the time have been Continuing Directors.

 

“Debt” shall mean,
with respect to any person, any indebtedness of such person, whether or not contingent, in respect of borrowed money or evidenced
by bonds, notes, debentures or similar instruments or letters of credit (or reimbursement agreements in respect thereof) or banker’s
acceptances or representing Capital Lease Obligations or the balance deferred and unpaid of the purchase price of any property
or representing any Hedging Obligations, except any such balance that constitutes an accrued expense or trade payable, if and to
the extent any of the foregoing indebtedness (other than letters of credit and Hedging Obligations) would appear as a liability
upon a balance sheet of such Person prepared in accordance with GAAP, as well as all Debt of others secured by a Lien on any asset
of such Person (whether or not such Debt is assumed by such Person) and Lease Debt and, to the extent not otherwise included, the
Guarantee by such Person of any Debt of any other Person. The indebtedness of the Company represented by this Note shall constitute
Debt. The amount of any Debt outstanding as of any date shall be (i) the accreted value thereof, in the case of any Debt that
does not require current payments of interest or (ii) the principal amount thereof, together with any interest thereon that
is more than 30 days past due, in the case of any other Debt.

 

“Default” means any
event that is or with the passage of time or the giving of notice or both would be an Event of Default.

 

“Disqualified Stock”
means any capital stock that, by its terms (or by the terms of any security into which it is convertible, or for which it is exchangeable,
in each case, at the option of the holder of the capital stock), or upon the happening of any event, matures or is mandatorily
redeemable, pursuant to a sinking fund obligation or otherwise, or redeemable at the option of the holder of the capital stock,
in whole or in part, on or prior to the date that is 91 days after the date on which this Note matures. The amount of Disqualified
Stock deemed to be outstanding at any time will be the maximum amount that the Company and its Subsidiaries may become obligated
to pay upon the maturity of, or pursuant to any mandatory redemption provisions of, such Disqualified Stock, exclusive of accrued
dividends.

 

“Exchange Act” means
the Securities Exchange Act of 1934, as amended, and the rules and regulations thereunder.

 

“GAAP” means generally
accepted accounting principles set forth in the opinions and pronouncements of the Accounting Principles Board of the American
Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards Board or in such
other statements by such other entity as have been approved by a significant segment of the accounting profession in the United
States, which are in effect from time to time.

 

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“Guarantee” means
a guarantee (other than by endorsement of negotiable instruments for collection in the ordinary course of business), direct or
indirect, in any manner (including, without limitation, by way of a pledge of assets, letters of credit and reimbursement agreements
in respect thereof), of all or any part of any Debt.

 

“Hedging Obligations”
means, with respect to any person, the obligations of such person under (i) currency exchange or interest rate swap agreements,
interest rate cap agreements and interest rate collar agreements and (ii) other agreements or arrangements designed to protect
such person against fluctuations in interest rates or currency exchange rates.

 

“Intellectual Property”
has the meaning ascribed thereto in the Agreement.

 

“Lease Debt” means,
with respect to any Person, (i) the amount of any accrued and unpaid obligations of such Person arising under any lease or
related document (including a purchase agreement, conditional sale or other title retention agreement) in connection with the lease
of real property or improvement thereon (or any personal property included as part of any such lease) which provides that such
Person is contractually obligated to purchase or cause a third party to purchase the leased property or pay an agreed upon residual
value of the leased property to the lessor (whether or not such lease transaction is characterized as an operating lease or a capitalized
lease in accordance with GAAP) and (ii) the guarantee, direct or indirect, in any manner (including, without limitation, letters
of credit and reimbursement agreements in respect thereof), of any of the amounts set forth in (i) above.

 

“Lien” means, with
respect to any asset, any mortgage, lien, pledge, charge, security interest or encumbrance of any kind in respect of such asset,
whether or not filed, recorded or otherwise perfected under applicable law (including any conditional sale or other title retention
agreement, any lease in the nature thereof, any option or other agreement to sell or give a security interest in and any filing
of or agreement to give any financing statement under the Uniform Commercial Code (or equivalent statutes) of any jurisdiction).
Notwithstanding the foregoing, a license or sublicense to any Intellectual Property shall not constitute a Lien hereunder.

 

“Permitted Transferees”
shall mean any Affiliate of Total Energies Nouvelles Activités USA.

 

“Person” means any
individual, corporation, limited liability company, partnership, joint venture, association, joint-stock company, trust, unincorporated
organization or government or any agency or political subdivision thereof.

 

“Registration Rights Agreement”
means that certain Registration Rights Agreement, dated July 30, 2012, by and among the Company and the Investor.

 

“Securities Act” means
the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.

 

“Significant Subsidiary”
means any Subsidiary of the Company that would be a “significant subsidiary” within the meaning specified in Rule 1-02(w)
of Regulation S-X promulgated by the Commission under the Exchange Act.

 

    	 	4	 

     

    

“Subsidiary” means,
with respect to any specified Person:

 

(1)any corporation, association or other business entity
of which more than 50% of the total voting power of shares of capital stock entitled (without regard to the occurrence of any contingency
and after giving effect to any voting agreement or stockholders’ agreement that effectively transfers voting power) to vote
in the election of directors, managers or trustees of the corporation, association or other business entity is at the time owned
or controlled, directly or indirectly, by that Person or one or more of the other Subsidiaries of that Person (or a combination
thereof); and

 

(2)any partnership (a) the sole general partner or the
managing general partner of which is such Person or a Subsidiary of such Person or (b) the only general partners of which are that
Person or one or more Subsidiaries of that Person (or any combination thereof).

 

“Trading Day” means,
with respect to the Common Stock, each Monday, Tuesday, Wednesday, Thursday and Friday, other than any day on which securities
are not generally traded on The NASDAQ Stock Market (or its successor) or such other principal securities exchange or inter-dealer
quotation system on which the shares of Common Stock are then traded.

 

“Transfer” means,
directly or indirectly, to offer, sell (including any short sale), transfer, assign, pledge, encumber, hypothecate or similarly
dispose of (by merger, testamentary disposition, operation of law or otherwise), either voluntarily or involuntarily, or enter
into any contract, option or other arrangement or understanding with respect to the offer, sale (including any short sale), transfer,
assignment, pledge, encumbrance, hypothecation or similar disposition of (by merger, testamentary disposition, operation of law
or otherwise), any Conversion Shares “beneficially owned” (as such term is defined in Rule 13d-3 and Rule 13d-5 under
the Exchange Act) by a Person or any interest (including any right to (x) all or any portion of the pecuniary interest in the security,
including, without limitation, the right to receive dividends and distributions, proceeds upon liquidation and receive the proceeds
of disposition or conversion (if applicable) of the security, or (y) direct the voting of the security with respect to any matter
for which the security is entitled to vote) in any Conversion Shares beneficially owned by a Person. Whether or not treated as
an offer or sale of the Conversion Shares under the Securities Act, “Transfer” shall also include any
hedging or other transaction entered into after the date hereof, such as any purchase, sale (including any short sale) or grant
of any right (including without limitation any put or call option) with respect to any of the Conversion Shares or with respect
to any security that includes or derives any significant part of its value from such Conversion Shares.

 

“Voting Shares” of
any person means capital shares or capital stock of such Person which ordinarily has voting power for the election of directors
(or persons performing similar functions) of such person, whether at all times or only so long as no senior class of securities
has such voting power by reason of any contingency.

 

2.               
Interest; Payment of Principal of Note; Cancellation of Note.

 

(a)                 
Interest. This Note shall bear interest from the Issue Date on the Face Amount at a rate per annum equal to
1.50% (subject to Section 5(c)). Interest on this Note shall

 

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accrue daily and be due and payable in arrears
on the Final Maturity Date and at such other times as may be specified herein. All computations of interest shall be made on the
basis of a 360-day year and actual days elapsed (which results in more interest being paid than if computed on the basis of a 365-day
year). Notwithstanding the foregoing, if an Event of Default shall have occurred and be continuing this Note shall bear interest
on the Face Amount at a rate per annum equal to 2.50% (as may be further adjusted pursuant to Section 5(c)).

 

(b)                 
Scheduled Payment of Principal. Unless paid, converted or cancelled and extinguished earlier in accordance
with the terms hereof, the Company shall deliver to the Investor cash in the amount of the Face Amount, together with all accrued
and unpaid interest on this Note, on March 1, 2017 (the “Final Maturity Date”) and this Note shall be
retired and canceled.

 

3.               
Conversion Rights; Adjustments. The Investor shall have conversion rights as follows
(the “Conversion Rights”):

 

(a)                 
Investor’s Right to Convert. At any time (i) after the tenth Trading Day prior to the Final Maturity
Date and prior to the fifth Trading Day prior to the Final Maturity Date, (ii) after the earlier to occur of (x) the occurrence
of a Change of Control and (y) the date of the Company’s delivery of the Change of Control Notice pursuant to Section 4(b),
and in each case and prior to the fifth Trading Day prior to the Final Maturity Date, or (iii) after the occurrence of an Event
of Default, the Investor shall have the right to convert the Face Amount of this Note, in whole or in part, at the option of the
Investor, at any time within the period specified above into a number of fully paid and nonassessable authorized but unissued Common
Stock determined by dividing (x) the Face Amount proposed to be converted at such date by (y) the then effective Conversion Price
on the Conversion Date (as defined in Section 3(c)(i)) (the “Investor Optional Conversion”).

 

(b)                 
The “Conversion Price” at which Common Stock shall be deliverable upon conversion of this Note (the “Conversion
Price”) shall initially be $3.08. Such initial Conversion Price shall be subject to adjustment as provided below.

 

(c)                 
Mechanics of Conversion.

 

(i)                
In order to exercise its rights pursuant to the Investor Optional Conversion, the Investor shall deliver written
notice in the form of Exhibit 1 to the Company stating that the Investor elects to convert all or part of the Face Amount
represented by this Note. Such notice shall state the Face Amount of this Note which the Investor seeks to convert and shall be
accompanied within one (1) Trading Day by this Note subject to conversion. The date contained in the notice (which date shall be
no earlier than the Trading Day immediately following the date of the notice) shall be the date of conversion of this Note (such
date of conversion, the “Conversion Date”) and the Investor shall be deemed to be the beneficial owner
of the underlying Common Stock as of such date.

 

(ii)              
The Investor shall be deemed to beneficially own the Common Stock underlying this Note as of the applicable Conversion
Date. Not later than three (3) Trading Days following the Conversion Date, the Company shall promptly issue and deliver to the
Investor a certificate or certificates for the number of
shares of Common Stock to which the Investor is entitled and, in the case where only part of this Note is converted, the Company
shall execute and deliver (at its own expense) a new unsecured convertible note of any authorized denomination as requested by
the Investor in an aggregate principal amount equal to and in exchange for the unconverted portion of the principal amount of this
Note so surrendered.

 

    	 	6	 

     

    

(iii)            
Upon conversion of this Note in whole or in part in accordance with the provision of Section 3(c) of this Note, the
Company shall pay to the Investor, substantially concurrently with delivery of the shares of Common Stock issuable on such conversion
(the “Conversion Shares”), any accrued and unpaid interest, through the day preceding the Conversion
Date, on the portion of the Face Amount represented by this Note that has been so converted. In addition, upon conversion of this
Note in whole or in part following a Change of Control, the Company shall pay to the Investor, substantially concurrently with
delivery of the Conversion Shares, an amount in cash equal to the interest that would have accrued at a rate per annum equal to
1.50% from such Conversion Date through the Final Maturity Date on the portion of the Face Amount represented by this Note that
has been so converted if such Note (or portion of the Note) had not been converted (“Make-Whole Interest”).
Notwithstanding the foregoing, in no event will the total amount of Make-Whole Interest exceed $360,389.61.

 

(iv)            
The Company shall at all times during which this Note shall be outstanding, have and keep available out of its authorized
but unissued shares, for the purpose of effecting the conversion of this Note, such number of its duly authorized shares of Common
Stock as shall from time to time be sufficient to effect the conversion of this Note. In no event shall the Conversion Price be
reduced to an amount less than the then par value of the Common Stock.

 

(v)              
No fractional shares of Common Stock shall be issued upon any conversion of this Note pursuant to this Section 3.
In lieu of fractional shares, the Company shall pay cash equal to such fraction multiplied by the Closing Price of the Common Stock
on the Conversion Date.

 

(vi)            
This Note (or the portions thereof), which shall have been surrendered for conversion as herein provided, shall no
longer be deemed to be outstanding and all rights with respect to such Note, except only the right of the Investor to receive shares
of Common Stock in exchange therefor, accrued and unpaid interest and Make-Whole Interest, if applicable, each as described in
Section 3(b)(iii) and, if applicable, cash for any fractional shares of Common Stock. This Note, to the extent so converted, shall
be retired and canceled.

 

(vii)          
If any conversion pursuant to this Section 3 is in connection with an underwritten offering of securities registered
pursuant to the Securities Act, the conversion may, at the option of the Investor, be conditioned upon the closing with the underwriter
of the sale of the Conversion Shares issuable to the Investor pursuant to such offering, in which event the Investor shall not
be deemed to have converted this Note until immediately prior to the closing of such sale of securities.

 

(d)                
Adjustment for Share Splits and Combinations. If the Company shall at any time or from time to time after
the Issue Date effect a subdivision of the outstanding shares of Common Stock, the Conversion Price and Conversion Price Floor
(as defined in Section 3(e))

 

    	 	7	 

     

    

then in effect immediately before that subdivision
shall be proportionately decreased. If the Company shall at any time or from time to time after the Issue Date combine the outstanding
shares of Common Stock, the Conversion Price and Conversion Price Floor then in effect immediately before the combination shall
be proportionately increased. Any adjustment under this paragraph shall become effective at the close of business on the date the
subdivision or combination becomes effective.

 

(e)                 
Adjustment for Certain Dividends and Distributions. In the event the Company at any time or from time to time
after the Issue Date, shall make or issue a dividend or other distribution payable in (x) additional shares of Common Stock, then
and in each such event the Conversion Price shall be decreased as of the time of such issuance, by multiplying such Conversion
Price by a fraction, the numerator of which shall be the total number of shares of Common Stock outstanding immediately prior to
such issuance and the denominator of which shall be the total number of shares of Common Stock outstanding immediately prior to
such issuance plus the number of such additional shares of Common Stock issuable in payment of such dividend or distribution; (y)
in cash, then and in each such event, the Conversion Price shall be decreased as of the time of such issuance, by multiplying such
Conversion Price by a fraction, the numerator of which shall be the Closing Price of the Common Stock on the Trading Day immediately
preceding the ex-dividend date for such dividend and distribution minus the amount in cash per share of Common Stock that the Company
dividends or distributes, and the denominator of which shall be the Closing Price of the Common Stock on the Trading Day immediately
preceding the ex-dividend date for such dividend and distribution; (z) shares of capital stock of the Company, evidences of indebtedness,
or any other asset (collectively, the “Distributed Property”), then and in each such event, the Conversion
Price shall be decreased as of the time of such issuance, by multiplying such Conversion Price by a fraction, the numerator of
which shall be the Closing Price of the Common Stock on the Trading Day immediately preceding the ex-dividend date for such dividend
and distribution minus the fair market value (as determined in good faith by the Company’s board of directors) of the Distributed
Property distributed with respect to each share of Common Stock, and the denominator of which shall be the Closing Price of the
Common Stock on the Trading Day immediately preceding the ex-dividend date for such dividend and distribution. Notwithstanding
the foregoing, in no event shall the Conversion Price be reduced below $2.78 (as may be adjusted pursuant to Section 3(d), the
“Conversion Price Floor”) pursuant to this clause (e). If a distribution or dividend would cause the
Conversion Price to be below the Conversion Price Floor if not for the immediately preceding sentence, the Company shall allow
the Investor to participate in the dividend or distribution as if it held the number of shares of Common Stock that this Note would
be convertible into at the close of business on the day immediately preceding the ex-dividend date or effective date, as the case
may be, for such distribution or dividend, and no adjustment shall be made to the Conversion Price as a result of such distribution
or dividend.

 

(f)                  
Adjustment for Reclassification, Exchange or Substitution. If at any time after the Issue Date, shares of
Common Stock of the Company shall be changed into the same or a different number of shares of any class or classes of shares, whether
by reclassification, or otherwise (other than a subdivision or combination of shares, share dividend or reorganization, reclassification,
merger, consolidation or asset sale provided for elsewhere in this Section 3), then and in each such event the Company shall enter
into an amendment to supplement this Note to provide that this Note will become convertible (subject to Section 3(a)) into the
kind and amount of shares and other securities and property receivable upon such reorganization, reclassification,

    	 	8	 

     

    

 

or other change, by holders of the number of shares
of Common Stock into which this Note might have been converted immediately prior to such reorganization, reclassification, or change,
all subject to further adjustment as provided herein or with respect to such other securities or property by the terms thereof.

 

(g)                 
Reorganizations, Mergers, Consolidations or Asset Sales. If at any time after the Issue Date there is a tender
offer, exchange offer, merger, consolidation, recapitalization, sale of all or substantially all of the Company’s assets
or reorganization involving the shares of Common Stock (collectively, a “Capital Reorganization”) (other
than a merger, consolidation, sale of assets, recapitalization, subdivision, combination, reclassification, exchange or substitution
of shares provided for elsewhere in this Section 3), as part of such Capital Reorganization, the Company shall enter into an amendment
or supplement to this Note to provide that this Note will become convertible (subject to Section 3(a)) into the number of shares
or other securities or property of the Company to which a holder of the number of shares of Common Stock deliverable upon conversion
immediately prior to such Capital Reorganization would have been entitled on such Capital Reorganization, subject to adjustment
in respect to such shares or securities by the terms thereof. In any such case, appropriate adjustment will be made in the application
of the provisions of this Section 3 with respect to the rights of the Investor after the Capital Reorganization to the end that
the provisions of this Section 3 (including adjustment of the Conversion Price then in effect and the number of Conversion Shares)
and the provisions of the Agreement and the Registration Rights Agreement will be applicable after that event and be as nearly
equivalent as practicable. In the event that the Company is not the surviving entity of any such Capital Reorganization, this Note
shall become the Note of such surviving entity, with the same powers, rights and preferences as provided herein.

 

(h)                 
No Impairment. The Company will not, by amendment of its Certificate of Incorporation or through any reorganization,
transfer of assets, consolidation, merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek
to avoid the observance or performance of any of the terms to be observed or performed hereunder by the Company, but will at all
times in good faith assist in the carrying out of all the provisions of this Section 3 and in the taking of all such action as
may be necessary or appropriate in order to protect the conversion rights of the Investor against impairment to the extent required
hereunder.

 

(i)                   
Certificate as to Adjustments or Distributions. Upon the occurrence of each adjustment of the Conversion Price
or distribution to holders pursuant to this Section 3, the Company at its expense shall promptly compute such adjustment or distribution
in accordance with the terms hereof and furnish to the Investor a certificate setting forth the terms of such adjustment or distribution
and showing in detail the facts upon which such adjustment or distribution are based and shall file a copy of such certificate
with its corporate records.

 

(j)                   
Notice of Record Date. In the event:

 

(i)                
that the Company declares a dividend (or any other distribution) on its Common Stock payable in shares of Common
Stock, securities, or other assets, rights or properties;

    	 	9	 

     

    

 

(ii)              
that the Company subdivides or combines its outstanding shares of Common Stock;

 

(iii)            
of any reclassification of the shares of Common Stock (other than a subdivision or combination of the Company’s
outstanding shares of Common Stock or a share dividend or share distribution thereon);

 

(iv)            
of any Capital Reorganization; or

 

(v)              
of the involuntary or voluntary dissolution, liquidation or winding up of the Company;

 

then the Company shall cause to be filed at its
principal office, and shall cause to be mailed to the Investor, at least ten (10) days prior to the record date specified in (A)
below or twenty (20) days prior to the date specified in (B) below, a notice stating:

 

(A)            
the record date of such dividend, distribution, subdivision or combination, or, if a record is not to be taken, the
date as of which the holders of shares of Common Stock of record to be entitled to such dividend, distribution, subdivision or
combination are to be determined, or

 

(B)             
the date on which such reclassification, Capital Reorganization, dissolution, liquidation or winding up is expected
to become effective, and the date as of which it is expected that holders of shares of Common Stock of record shall be entitled
to exchange their shares of Common Stock for securities or other property deliverable upon such reclassification, Capital Reorganization,
dissolution or winding up

 

(k)                 
Notice of Adjustment to Conversion Price. The Company will provide notice to the Investor upon the occurrence
of any adjustment to the Conversion Price.

 

4.               
Repurchase Right Upon a Change of Control.

 

(a)                 
Upon the occurrence of a Change of Control, the Investor may elect, as an alternative to the Investor’s right
to convert this Note pursuant to Section 3 above, to require the Company to repurchase all or any part of this Note pursuant to
an offer as provided in this Section 4 (the “Change of Control Offer”) at an offer price in cash equal
to 101% of the Face Amount of this Note, plus any accrued and unpaid interest as of the Change of Control Payment Date (as defined
in Section 4(b)(i)) (the “Change of Control Payment”).

 

(b)                 
On or before the 30th day after a Change of Control, the Company shall give to the Investor notice (the “Change
of Control Notice”) of the occurrence of the Change of Control and of the Investor’s right to receive the Change
of Control Payment arising as a result thereof. Each notice of the Investor’s right to participate in the Change of Control
Offer (the “Change of Control Repurchase Right”) shall be mailed to the Investor pursuant to Section
15 and shall state:

 

    	 	10	 

     

    

(i)                
the date on which this Note shall be repurchased (the “Change of Control Payment Date”),
which date shall be no earlier than 30 days and no later than 60 days from the date of the Company’s delivery of the Change
of Control Notice;

 

(ii)              
the date by which the Change of Control Repurchase Right must be exercised, which date shall be no earlier than the
close of business on the Trading Day immediately prior to the Change of Control Payment Date;

 

(iii)            
the amount of the Change of Control Payment;

 

(iv)            
a description of the procedure which the Investor must follow to exercise the Change of Control Repurchase Right,
and the place or places where this Note is to be surrendered for payment of the Change of Control Payment; and

 

(v)              
the Conversion Price then in effect and the place where this Note may be surrendered for conversion.

 

No failure by the Company to give the Change of
Control Notice and no defect in any Change of Control Notice shall limit the Investor’s right to exercise its Change of Control
Repurchase Right or affect the validity of the proceedings for the repurchase of this Note. If any of the foregoing provisions
or other provisions of this Section 4 are inconsistent with applicable law, such law shall govern.

 

(c)                 
To exercise the Change of Control Repurchase Right, the Investor shall deliver to the Company, on or before the Trading
Day immediately prior to the Change of Control Payment Date, (i) written notice of the Investor’s exercise of such right,
which notice shall set forth the name of the Investor, the Face Amount of this Note, and a statement that an election to exercise
the Change of Control Repurchase Right is being made thereby, and (ii) this Note. Such written notice shall be irrevocable,
except that the right of the Investor to convert this Note shall continue until midnight (Eastern Time) on the Trading Day immediately
preceding the Change of Control Repurchase Date.

 

(d)                
On the Change of Control Payment Date, the Company will (i) accept for payment this Note or portions thereof
properly tendered pursuant to the Change of Control Offer and (ii) deliver cash in the amount of the Change of Control Payment
to the Investor in respect of this Note or portions thereof so tendered. This Note or portion thereof repurchased by the Company
shall be canceled immediately by the Company

 

(e)                 
The Company shall publicly announce the results of the Change of Control Offer on or as soon as practicable after
the Change of Control Payment Date.

 

(f)                  
The Company will comply with the requirements of Rule 14e-1 under the Exchange Act and any other securities laws
and regulations thereunder to the extent such laws and regulations are applicable in connection with the repurchase of this Note
as a result of a Change of Control.

 

(g)                 
If this Note is repurchased only in part, it shall be surrendered to the Company and the Company shall execute and
make available for delivery to the Investor, without

 

service charge, a new unsecured convertible note
or notes containing identical terms and conditions, each in an authorized denomination in aggregate principal amount equal to and
in exchange for the unrepurchased portion of the principal of the Note so surrendered. If this Note is surrendered to the Company
pursuant to the provisions of this Section 4, it shall be retired and cancelled.

 

    	 	11	 

     

    

(h)                 
The Company will not be required to make a Change of Control Offer upon a Change of Control if a third party makes
the Change of Control Offer in the manner, at the times and otherwise in compliance with the requirements set forth in this Section
4 applicable to a Change of Control Offer made by the Company and purchases this Note validly tendered and not withdrawn under
such Change of Control Offer.

 

(i)                   
Events of Default. Definitions. For purposes of this Note, the following events shall constitute an “Event
of Default”:

 

(i)                
default in payment when due (whether at the Final Maturity Date or upon an earlier repurchase) of the principal of,
or premium, if any, on this Note;

 

(ii)              
default in the payment of an installment of interest on this Note, which failure continues for thirty (30) days after
the date when due;

 

(iii)            
failure by the Company for thirty (30) days after notice from the Investor to comply with the provisions of Section
4 or Section 6 of this Note;

 

(iv)            
failure by the Company for sixty (60) days after notice from the Investor to comply with any of its other agreements
in this Note or the Agreement (other than Section 8.6(b) of the Agreement);

 

(v)              
default under any mortgage, indenture or instrument under which there may be issued or by which there may be secured
or evidenced any Debt for money borrowed by the Company (or the payment of which is guaranteed by the Company, whether such Debt
or guarantee existed as of the Original Issue Date or is created after the Original Issue Date, which default (a) is caused by
a failure to pay principal of or premium, if any, or interest on such Debt prior to the expiration of the grace period provided
in such Debt on the date of such default or (b) results in the acceleration of such Debt prior to its express maturity and, in
each case in clause (a) or (b), the principal amount of any such Debt, together with the principal amount of any other such Debt
that has not been paid when due, or the maturity of which has been so accelerated, aggregates $10,000,000 or more;

 

(vi)            
failure by the Company to pay final judgments aggregating in excess of $10,000,000, which judgments are not paid,
discharged or stayed for a period of sixty (60) days;

 

(vii)          
the Company:

 

(A)            
commences a voluntary case under any Bankruptcy Law,

 

(B)             
consents to the entry of an order for relief against it in an involuntary case under any Bankruptcy Law,

 

    	 	12	 

     

    

(C)             
consents to the appointment of a custodian of it or for all or substantially all of its property,

 

(D)            
makes a general assignment for the benefit of its creditors, or

 

(E)             
is unable to pay its debts as they become due; or

 

(viii)        
a court of competent jurisdiction enters an order or decree under any Bankruptcy Law that:

 

(A)            
is for relief against the Company;

 

(B)             
appoints a custodian of the Company or any of its Significant Subsidiaries or for all or substantially all of the
property of the Company; or

 

(C)             
orders the liquidation of the Company and the order or decree remains unstayed and in effect for sixty (60) consecutive
days; or

 

(ix)failure by the Company to deliver when
due the consideration deliverable upon conversion of this Note, which failure shall continue for a period of five days.

 

(j)                   
Notice of Compliance. The Company shall be required to deliver to the Investor annually a statement regarding
compliance with this Note, and the Company shall be required within five (5) days of becoming aware of any Default or Event of
Default (or such earlier date as any such statement is provided to the holders of the Debt incurred pursuant to the Securities
Purchase Agreement dated as of February 24, 2012) to deliver to the Investor a statement specifying such Default or Event of Default.

 

(k)                 
Acceleration. If any Event of Default occurs and is continuing, the Investor may declare this Note to be due
and payable immediately. Notwithstanding the foregoing, in the case of an Event of Default described in Section 5(vii) or (viii)
with respect to the Company this Note, to the extent outstanding, will become due and payable without further action or notice.
The Investor may rescind an acceleration and its consequences if the rescission would not conflict with any judgment or decree.
Notwithstanding the foregoing (or anything to the contrary in the Agreement), the sole remedy of the Investor for a failure by
the Company to comply with Section 8.6(b) of the Agreement shall, for the first 365 days after the occurrence of such failure,
be the right, by notice to the Company by the Investor, to increase in the rate of interest on this Note to 6% for the first 180
days of such failure, and to 9% thereafter (which increased interest shall constitute liquidated damages for such failure).

 

(l)                   
Waiver of Past Defaults. The Investor may waive any existing Default or Event of Default and its consequences
under this Note. Upon any such waiver, such Default shall cease to exist, and any Event of Default arising therefrom shall be deemed
to have been cured for every purpose of this Note, but no such waiver shall extend to any subsequent or other default or impair
any right consequent thereon.

    	 	13	 

     

    

 

(m)               
Rights of Investor to Receive Payment. Notwithstanding any other provision of this Note, the right of the
Investor to receive payment of the principal of, and premium on, this Note, on or after the respective due dates expressed in this
Note (including in connection with a redemption or an offer to purchase), or to bring suit for the enforcement of any such payment
on or after such respective dates, shall not be impaired or affected without the consent of the Investor

 

5.               
Limitation on Debt and Liens. The Company will not, and will not permit its Subsidiaries
to, directly or indirectly, create, incur, issue, assume, guarantee or otherwise become directly or indirectly liable, contingently
or otherwise, with respect to any Debt, and the Company will not issue any Disqualified Stock and the Company will not permit its
Subsidiaries to issue shares of preferred stock except for: 

 

(a)                 
Debt in an amount outstanding at any time not to exceed the greater of (i) $200 million in aggregate principal amount
or (ii) 50% of the Company’s total consolidated assets (as set forth on its most recent balance sheet prepared in accordance
with GAAP and filed with the Securities and Exchange Commission after giving effect to any reductions or additions to assets in
accordance with GAAP since the date of such balance sheet) (the “Maximum Debt Amount”); provided that
Debt incurred pursuant to this clause (a) that is secured by a Lien on assets of the Company shall not exceed the greater of (i)
$125 million in aggregate principal amount or (ii) 30% of the Company’s total consolidated assets (as set forth on its most
recent balance sheet prepared in accordance with GAAP) (the “Maximum Secured Debt Amount”);

 

(b)                 
Debt in existence on February 27, 2012;

 

(c)                 
the incurrence by the Company or any of its Subsidiaries of Debt represented by Capital Lease Obligations, mortgage
financings or purchase money obligations, in each case, incurred for the purpose of financing all or any part of the purchase price
or cost of design, construction, installation or improvement of property, plant or equipment used in the business of the Company
or any of its Subsidiaries.

 

(d)                
Debt of the Company that is (i) contractually subordinated in right of payment to this Note, (ii) matures 91 days
after this Note and (iii) is less than $50 million in aggregate principal amount at any one time outstanding;

 

(e)                 
Debt of the Company (A) in respect of performance, surety or appeal bonds or letters of credit in the ordinary
course of business, or (B) under interest rate, currency, commodity or similar hedges, swaps and other derivatives entered
into with one or more financial institutions that is designed to protect such the Company against fluctuations in interest rates
or currency exchange rates, commodity prices or other market fluctuations and is not entered into for speculative purposes; and

 

(f)                  
Debt which is exchanged for or the proceeds of which are used to refinance or refund, or any extension or renewal
of (each a "refinancing"), (1) this Note or (2) debt in existence on the Original Issue Date, and (3) Debt
incurred pursuant to clause (c) of this paragraph, in each case in an aggregate principal amount not to exceed the principal amount
of the Debt so refinanced (together with any accrued interest and any premium and other payment required to be

    	 	14	 

     

    

 

made with respect to the Debt being refinanced
or refunded, and any fees, costs, expenses, underwriting discounts or commissions and other payments paid or payable with respect
to the Debt incurred pursuant to this clause (f)); provided, however, that (A) Debt, the proceeds of which are used to
refinance this Note, or Debt which is pari passu with this Note (including Debt incurred pursuant to the Securities Purchase Agreement,
dated as of February 24, 2012, among the Company and the purchasers named therein) or subordinate in right of payment to this Note,
shall only be permitted if (x) in the case of any refinancing of this Note or Debt which is pari passu to this Note (including
Debt incurred pursuant to the Securities Purchase Agreement, dated as of February 24, 2012, among the Company and the purchasers
named therein), the refinancing Debt is incurred by the Company and made pari passu to this Note or subordinated to this Note,
and (y) in the case of any refinancing of Debt which is subordinated to this Note, the refinancing Debt is incurred by the
Company and is subordinated to this Note in a manner that is at least as favorable to the Investor as that of the Debt refinanced;
(B) refinancing Debt with respect to Debt incurred pursuant to clause (c) of this paragraph shall not be secured by a Lien on any
assets other than the assets securing the Debt so refinanced, and any improvements or additions thereto, and (C) the refinancing
Debt by its terms, or by the terms of any agreement or instrument pursuant to which such Debt is issued, does not have a final
maturity prior to the final maturity of the Debt being refinanced.

 

For purposes of determining compliance with
this Section 6, in the event that an item of Debt meets the criteria of more than one of the types of Debt described in the
above clauses the Company, in its sole discretion, shall classify, and from time to time may reclassify, such item of Debt.

 

(g)                 
The Company will not create, incur, assume or suffer to exist any Lien of any kind on any asset now owned or hereafter
acquired, except for (a) the Liens described in Section 6(a) and 6(c) (including the refinancing of Liens described in Section
6(c) pursuant to Section 6(f)), (b) Permitted Liens, and (c) any Liens in existence on the Original Issue Date (including the refinancing
thereof pursuant to Section 6(f)) (excluding any Liens previously waived by the Investor prior to the Issue Date). Notwithstanding
the foregoing, there shall be no restriction under this Note or the Agreement on the ability of the Company to create, incur, assume
or suffer to exist any Lien of any kind on any of its Intellectual Property.

 

As used herein, “Permitted Liens”
means the following: (a) Liens for taxes, assessments and governmental charges or levies that are not overdue for a period of more
than thirty (30) days or which are being contested in good faith; (b) Liens imposed by law, such as materialmen’s, mechanics’,
carriers’, workmen’s and repairmen’s Liens and other similar Liens securing obligations that are not overdue
for a period of more than thirty (30) days or that are being contested in good faith; (c) pledges or deposits to secure obligations
under workers’ compensation laws or similar legislation or to secure public or statutory obligations; (d) easements,
rights of way and other encumbrances on title to real property that do not render title to the property encumbered thereby unmarketable
or materially adversely affect the use of such property for its present purposes; (e) Liens to secure the performance of bids,
trade contracts, leases, statutory obligations, surety and appeal bonds, performance bonds and other obligations of a like nature;
(f) landlords’ Liens under leases; (g) Liens consisting of leases, subleases, licenses or sublicenses granted to others
and not interfering in any material respect with the business of the Company and its Subsidiaries, taken as a whole, and any interest
or title of a lessor or licensor under any lease or

    	 	15	 

     

    

 

license, as applicable; (h) Liens arising
solely by virtue of any statutory or common law provision relating to banker’s Liens, rights of set-off or similar rights
and remedies as to deposit accounts or other funds maintained with a creditor depository institution; and (i) Liens securing
judgments for the payment of money not constituting an Event of Default under Section 5(a)(vi) or securing appeal or other surety
bonds related to such judgments.

 

6.               
Successors.

 

(a)                 
Merger, Consolidation or Sale of Assets. The Company shall not consolidate or merge with or into (whether
or not the Company is the surviving corporation), or sell, assign, transfer, lease, convey or otherwise dispose of all or substantially
all of its properties or assets in one or more related transactions, to another corporation, Person or entity unless:

 

(i)                
the entity or Person formed by or surviving any such consolidation or merger (if other than the Company), or the
parent company thereof, or the entity or Person to which such sale, assignment, transfer, lease, conveyance or other disposition
shall have been made assumes all the obligations of the Company under this Note and the Agreement; and

 

(ii)              
immediately after such transaction no Default or Event of Default exists.

 

(b)                 
Successor Corporation Substituted. Upon any consolidation or merger or any transfer of all or substantially
all of the assets of the Company in accordance with Section 6(a) hereof, the successor Person formed by such consolidation or into
which the Company is merged, or the parent company thereof, or to which such transfer is made shall succeed to and (except in the
case of a lease) be substituted for (so that from and after the date of such consolidation, merger or transfer, the provisions
of this Note, the Agreement and the Registration Rights Agreement referring to the “Company” shall refer instead to
the successor Person and not to the Company), and may exercise every right and power of, the Company under this Note and the Agreement
with the same effect as if such successor Person had been named herein as the Company, and (except in the case of a lease) the
Company shall be released from the obligations under this Note and the Agreement except with respect to any obligations that arise
from, or are related to, such transaction.

 

7.               
Amendment and Waiver. Except as otherwise expressly provided herein, the provisions
of this Note may be amended and the Company may take any action herein prohibited, or omit to perform any act herein required to
be performed by it, only if the Company has obtained the written consent of the Investor.

 

8.               
Place of Payment. Payments of principal, interest, and premium, if any, consideration
deliverable upon conversion of this Note (unless otherwise specified in the conversion notice) and all notices and other communications
to the Investor hereunder or with respect hereto are to be delivered to the Investor at the address identified in the Agreement
or to such other address or to the attention of such other person as specified by prior written notice to the Company, including
any Permitted Transferee of this Note in accordance with Section 3 of this Note.

    	 	16	 

     

    

 

9.               
 Costs of Collection. In the event that the Company fails to (a) pay when due (including,
without limitation upon acceleration in connection with an Event of Default) the full amount of principal, interest and/or premium
hereunder or (b) deliver when due the consideration deliverable upon conversion of this Note, the Company shall indemnify and hold
harmless the Investor of any portion of this Note from and against all reasonable costs and expenses incurred in connection with
the enforcement of this provision or collection of such principal, interest, premium and/or consideration, including, without limitation,
reasonable attorneys’ fees and expenses.

 

10.           
Waivers. The Company hereby waives presentment, demand, notice, protest and all
other demands and notices in connection with the delivery, acceptance, performance, default or enforcement of this Note.

 

11.           
Benefits of the Agreement. The Investor and all transferees of this Note (to the
extent such transfer is permitted by the Agreement) shall be entitled to the rights and benefits granted to them in the Agreement.

 

12.           
Registration of Transfer and Exchange Generally.

 

(a)                 
Registration, Registration of Transfer and Exchange Generally. The Company shall keep at its principal executive
offices a register (the register maintained in such being herein sometimes collectively referred to as the “Note Register”)
in which the Company shall provide for the registration of this Note and of transfers and exchanges of it.

 

Subject to the provisions of the Agreement regarding
restrictions on transfer and provided the Permitted Transferee agrees to be bound by the terms of this Note and the Agreement,
upon surrender for registration of transfer of this Note at its principal executive office, the Company shall execute and deliver,
in the name of the designated transferee or transferees, one or more new unsecured convertible notes in denominations requested
by the transferee (which denominations shall not be less than $1,000,000 per note (unless the transferor holds a lesser denomination,
in which case no such restriction shall apply)), of a like aggregate principal amount and bearing such restrictive legends as may
be required by law.

 

At the option of the Investor, this Note may
be exchanged for other unsecured convertible notes of any authorized denominations, of a like aggregate principal amount and bearing
such restrictive legends as may be required by law upon surrender at the Company’s principal executive offices. Whenever
this Note is so surrendered for exchange, the Company shall execute and make available for delivery the unsecured convertible Note(s)
that the Investor making the exchange is entitled to receive.

 

All unsecured convertible notes issued upon
any registration of transfer or exchange of this Note shall be the valid obligations of the Company, evidencing the same debt,
and entitled to the same benefits as this Note surrendered upon such registration of transfer or exchange.

 

This Note, if presented or surrendered for registration
of transfer or for exchange, shall (if so required by the Company) be duly endorsed, or be accompanied by a written instrument
of transfer in form satisfactory to the Company, duly executed by the Investor.

 

    	 	17	 

     

    

No service charge shall be made for any registration
of transfer or exchange of this Note.

 

(b)                 
Mutilated, Destroyed, Lost and Stolen Notes. If this Note is mutilated and surrendered to the Company, the
Company shall execute and make available for delivery in exchange therefor a new unsecured convertible note of like tenor and principal
amount and bearing a number not contemporaneously outstanding.

 

If there shall be delivered to the Company (i) evidence
to its reasonable satisfaction of the destruction, loss or theft of this Note and (ii) such indemnity as may be reasonably
requested by the Company to save itself harmless, then, in the absence of notice to the Company that such Note has been acquired
by a protected purchaser, the Company shall execute and make available for delivery, in lieu of any such destroyed, lost or stolen
Note, a new unsecured convertible note of like tenor and principal amount and bearing a number not contemporaneously outstanding.

 

Every new unsecured convertible note issued
pursuant to this Section 13 in lieu of any mutilated, destroyed, lost or stolen Note shall constitute an original additional contractual
obligation of the Company, whether or not the destroyed, lost or stolen Note shall be at any time enforceable by anyone.

 

The provisions of this Section 13 are exclusive
and shall preclude (to the extent lawful) all other rights and remedies with respect to the replacement or payment of mutilated,
destroyed, lost or stolen Note.

 

13.           
Governing Law.

 

(a)This
Note, and the provisions, rights, obligations, and conditions set forth herein, and the legal relations between the parties hereto,
including all disputes and claims, whether arising in contract, tort, or under statute, shall be governed by and construed in accordance
with the laws of the State of New York without giving effect to its conflict of law provisions.

 

(b)Any and all disputes arising out
of, or in connection with, the interpretation, performance, or nonperformance of this Note or any and all disputes arising out
of, or in connection with, transactions in any way related to this Note and/or the relationship between the parties shall be litigated
solely and exclusively before the United States District Court for the Southern District of New York. The parties consent to the
in personam jurisdiction of said court for the purposes of any such litigation, and waive, fully and completely, any right to dismiss
and/or transfer any action pursuant to 28 U.S.C. § 1404 or 1406 (or any successor statute). In the event the United States
District Court for the Southern District of New York does not have subject matter jurisdiction of said matter, then such matter
shall be litigated solely and exclusively before the appropriate state court of competent jurisdiction located in the state of
New York.

 

14.           
Notices. All notices, requests, and other communications hereunder shall be in
writing and will be deemed to have been duly given and received (a) when personally delivered, (b) when sent by facsimile
upon confirmation of receipt, (c) one business day after the day on which the same has been delivered prepaid to a nationally
recognized courier service, or (d) five

    	 	18	 

     

    

 

business days
after the deposit in the United States mail, registered or certified, return receipt requested, postage prepaid, in each case to
the applicable address set forth below: 

 

	 	(i)	if to the Company, to:
	 	 	 
	 	 	Amyris, Inc.
	 	 	5885 Hollis Street, Suite 100
	 	 	Emeryville, CA 94608
	 	 	United States of America
	 	 	Attn:  General Counsel
	 	 	Fax. No.:  
	 	 	 
	 	(ii)	if to the Investor, to:
	 	 	 
	 	 	Total Energies Nouvelles Activités  USA
	 	 	24 Cours Michelet
	 	 	92800 Puteaux
	 	 	France
	 	 	Attn:  
	 	 	Fax. No.:  
	 	 	 
	 	 	with copies (which shall not constitute notice) to:
	 	 	 
	 	 	Wilson Sonsini Goodrich & Rosati
	 	 	Professional Corporation
	 	 	650 Page Mill Road
	 	 	Palo Alto, CA 94304
	 	 	United States of America
	 	 	Attn:  
	 	 	 
	 	 	Fax No.:  
	 	 	 
	 	 	and
	 	 	 
	 	 	Jones Day
	 	 	555 California Street, 26th Floor
	 	 	San Francisco, CA 94104-1500
	 	 	United States of America
	 	 	Attn:  
	 	 	Fax No.:  

 

Any party hereto
from time to time may change its address, facsimile number, or other information for the purpose of notices to that party by giving
notice specifying such change to the other parties hereto. The Investor and the Company may each agree in writing to accept notices
and other communications to it hereunder by electronic communications pursuant to procedures reasonably 

 

    	 	19	 

     

    

approved by
it; provided that approval of such procedures may be limited to particular notices or communications.

 

 

[Signature Page Follows]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

    	 	20	 

     

    

 

IN WITNESS WHEREOF, the Company has executed
and delivered this Note on March 21, 2016.

 

	 	AMYRIS, INC.	 
	 	 	 	 
	 	 	 	 
	 	By:	/s/ Raffi Asadorian	 
	 	Name:     Raffi Asadorian 	 
	 	Title:       Chief Financial Officer 	 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

    [Signature Page to Note RS-10]

     

    

 

EXHIBIT 1

 

(To be Executed by Investor in order to Convert
Note)

 

CONVERSION NOTICE

FOR

1.5% SENIOR CONVERTIBLE NOTE DUE 2017

 

The undersigned, as holder of the 1.5% Senior
Convertible Note due 2017 of AMYRIS, INC., (the “Company”), in the outstanding principal amount
of U.S. $3,700,000.00 and designated RS-10 (the “Note”), hereby elects to convert that portion of the
outstanding principal amount of the Note shown on the next page into shares of the Company’s common stock, $0.0001 par value
per share (the “Common Stock”), of the Company, accrued and unpaid interest and Make-Whole Interest,
if any, in accordance with and in compliance with the conditions of the Note, as of the date written below. The undersigned hereby
requests that share certificates for the shares of Common Stock to be issued to the undersigned pursuant to this Conversion Notice
be issued in the name of, and delivered to, the undersigned or its designee as indicated below. If shares are to be issued in the
name of a person other than the undersigned, the undersigned will pay all transfer taxes payable with respect thereto. No fee will
be charged to the Investor for any conversion, except for transfer taxes, if any.

 

	Conversion Information:	TOTAL ENERGIES NOUVELLES ACTIVITÉS USA:
	 	 	 	 	 
	 	By:	 	 
	 	Print Name:	 
	 	Print Title:	 
	 	 	 	 	 
	 	Address:	 
	 	24 Cours Michelet	 
	 	92800 Puteaux, France	 
	 	Attn:	 	 
	 	Fax. No.: 	 	 
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 
	 	Issue Common Stock:	 	 
	 	 	 	 	 
	 	at:	 	 
	 	 	 	 	 
	 	Date of Conversion	 
	 	 	 
	 	Applicable Conversion Price	 
	 	 	 

 

 

     

     

    

 

THE COMPUTATION OF THE NUMBER OF SHARES OF COMMON STOCK TO

BE RECEIVED IS SET FORTH ON THE ATTACHED PAGE

  

	Page 2 to Conversion Notice for:	
        Total Energies Nouvelles Activités USA

 

 

COMPUTATION OF NUMBER OF COMMON SHARES TO BE RECEIVED

 

	Face Amount converted:	 	$	 	 
	 	 	 	 	 
	Conversion Price	 	$	 	 
	 	 	 	 	 
	Number of shares of Common Stock =	Total dollar amount converted   =	$	 	 
	 	Conversion Price	 	 	 
	Number of shares of Common Stock =	 	 	 	 
	 	 	 	 	 
	Please issue and deliver ___ certificate(s) for shares of Common Stock in the following amount(s):	 
	 	 
	 	 
	 	 
	 	 
	 	 
	Please issue and deliver ______ new unsecured convertible note(s) in the following amounts:Exhibit 4.50

 

Note and warrant pUrchase
AGREEMENT

 

This Note and Warrant Purchase Agreement (this
“Agreement”) is made as of February 12, 2016 (the “Effective Date”) by and among Amyris,
Inc., a Delaware corporation (the “Company”), and the individuals or entities listed on Schedule I hereto
(each, a “Purchaser,” and collectively, the “Purchasers”).

 

Preliminary Statement

 

Subject to the terms and conditions hereof,
each Purchaser desires to purchase, and the Company desires to offer and sell to each Purchaser, (i) that aggregate principal amount
of Unsecured Promissory Notes with a principal amount set forth opposite each such Purchaser’s name on Schedule I
hereto (which aggregate principal amount for all Purchasers as of the Initial Closing (as defined below) shall be $18,000,000)
(each such Unsecured Promissory Note, a “Note” and collectively, the “Notes”), and (ii) warrants,
in substantially the form attached hereto as Exhibit B (collectively, the “Warrants”), to acquire up
to that number of shares of the Company’s common stock, $0.0001 par value per share (the “Common Stock”),
as determined pursuant to Article 8 of this Agreement and set forth on Schedule I hereto (with the shares of Common Stock
issuable upon exercise of or otherwise pursuant to the Warrants being referred to herein as the “Warrant Shares”).
If and when issued, each of the Notes shall be evidenced by a promissory note in the form attached hereto as Exhibit A.

 

The Notes, the Warrants and the Warrant Shares
issued pursuant to this Agreement are collectively referred to herein as the “Securities.”

 

Agreement

 

The parties, intending to be legally bound, agree as follows:

 

1.     
Sale of Notes and Warrants.

 

(a)               
Subject to the terms and conditions hereof, at the Initial Closing (as defined in Section 2) or any subsequent Closing (as
defined in Section 2), the Company shall sell to each Purchaser, and, subject to satisfaction of the conditions set forth in this
Agreement, each such Purchaser will purchase from the Company, (i) a Note in a principal amount as set forth next to such Purchaser’s
name on Schedule I hereto for a purchase price equal to the purchase price set forth next to such Purchaser’s name
on Schedule I hereto under the column “Note Purchase Price” (the “Note Purchase Price”), and (ii)
a Warrant exercisable for that number of shares of Common Stock set forth next to such Purchaser’s name on Schedule I
hereto for a purchase price equal to the purchase price set forth next to such Purchaser’s name on Schedule I hereto
under the column “Warrant Purchase Price” (the “Warrant Purchase Price” and together with the Note
Purchase Price, the “Purchase Price”). The sale and purchase of the Notes and Warrants to each Purchaser shall
constitute a separate sale and purchase hereunder. Notwithstanding the foregoing, the Purchasers hereby acknowledge that the Warrants
shall only be exercisable if the Warrants have been approved by a majority of the Company’s stockholders whose vote is counted
at the Stockholders Meeting (as defined in Section 9) in accordance with Section 9 of this Agreement.

 

    	 	1	 

     

    

(b)              
The Company and each Purchaser, having adverse interests and as a result of arm’s length bargaining, agree that 80.14%
of the principal amount of such Purchaser’s Note shall be allocated to such Purchaser’s Note and 19.86% to such Purchaser’s
Warrant, and further agree that neither such Purchaser’s Note nor such Purchaser’s Warrant are being issued in whole
or in part as compensation for services rendered to the Company. Each party shall ensure that all its tax returns and other filings
relating to such Notes and Warrants shall consistently reflect the matters agreed upon in this Section 1(b).

 

2.     
Closing.

 

(a)               
The initial closing (“Initial Closing”) of the transactions contemplated hereby shall be held at the
offices of Fenwick & West LLP, 801 California Street, Mountain View, California 94041 within one business day following the
date on which the last of the conditions set forth in Sections 7 and 8 have been satisfied or waived in accordance with this Agreement
but in no event later than February 15, 2016 (such date, the “Initial Closing Date”), or at such other time
and place as the Company and the Purchasers mutually agree upon.

 

(b)              
At any time and from time to time after the Initial Closing, the Company may sell, on the same terms and conditions as those
contained in this Agreement, without obtaining the signature, consent or permission of any of the Purchasers, up to $2,000,000
in aggregate principal amount of Notes together with Warrants to purchase up to an aggregate of 285,714 shares of Common Stock
(subject to appropriate adjustment in the event of any stock dividend, stock split, combination or similar recapitalization affecting
such shares), to one or more purchasers in additional closings (each, an “Additional Closing” and any Initial
Closing or Additional Closing being referred to herein as a “Closing”), provided that (i) each such subsequent
sale is consummated prior to 30 days after the Initial Closing, and (ii) each such purchaser shall become a party to the Transaction
Agreements (as defined below) as a Purchaser hereunder, by executing and delivering a counterpart signature page to each of the
Transaction Agreements. Schedule I to this Agreement shall be updated to reflect the number of Notes and Warrants purchased
at each such Closing and the parties purchasing such Notes and Warrants.

 

3.     
Delivery.

 

(a)               
At each Closing, each Purchaser at such Closing shall (i) pay the Company the applicable Purchase Price in immediately available
funds, or (ii) (A) initiate irrevocable payment instructions to its paying bank to make the payment (an “Irrevocable Payment
Instruction”) to the Company of the applicable Purchase Price in immediately available funds and (B) deliver to the Company
confirmation that such Purchaser has made an Irrevocable Payment Instruction, such confirmation to be in the form of a federal
reference number or other similar written evidence that a wire has been initiated.

 

(b)              
At each Closing, or, if applicable, upon receipt of the applicable amount of the Purchase Price due in respect of such Closing
from any Purchaser who makes an Irrevocable Payment Instruction at such Closing, the Company shall deliver to such Purchaser a
Note with a principal amount as provided in Section 1 above and a Warrant exercisable (subject to the Stockholder Approval (as
defined in Section 9 of this Agreement)) for that number of shares of Common Stock as provided in Section 1 above, such Note and
Warrant to be registered in the

 

    	 	2	 

     

    

name of such Purchaser, or in such nominee’s
or nominees’ name(s) as provided by such Purchaser to the Company, against payment of the Purchase Price therefor as provided
in Section 1 above by wire transfer of immediately available funds to such account or accounts as the Company shall designate
in writing to such Purchaser at least two (2) days prior to the date of such Closing.

 

4.     
Company Representations. The Company represents and warrants to the Purchasers as follows: 

 

(a)               
Organization and Standing. The Company is duly incorporated, validly existing, and in good standing under the laws
of the State of Delaware. The Company has all requisite power and authority to own and operate its properties and assets and to
carry on its business as presently conducted and as proposed to be conducted. The Company is qualified to do business as a foreign
entity in every jurisdiction in which the failure to be so qualified would have, or would reasonably be expected to have, a material
adverse effect, individually or in the aggregate, upon the business, properties, tangible and intangible assets, liabilities, operations,
prospects, financial condition or results of operation of the Company or the ability of the Company to perform its obligations
under this Agreement (a “Material Adverse Effect”). For the purposes of clarity, the implementation of any plan
for the significant restructuring of the Company, which has been approved by the Board of Directors of the Company as of the date
hereof, shall not constitute a Material Adverse Effect.

 

(b)              
Power. The Company has all requisite power to execute and deliver this Agreement, to sell and issue the Notes and
Warrants hereunder, and to carry out and perform its obligations under the terms of this Agreement, the Notes and the Warrants
(collectively, the “Transaction Agreements”).

 

(c)               
Authorization. Subject to any waivers or consents required under the ROFI Agreements (as defined in Section 4(f)
below) and any waivers of covenants limiting the Company’s ability to incur further debt under outstanding debt instruments
and loans, each of which would be obtained or waived as required prior to the Initial Closing (the “Pre-Closing Consents”),
execution, delivery, and performance of the Transaction Agreements by the Company has been duly authorized by all requisite action
on the part of the Company and its officers, directors and stockholders, and this Agreement, the Notes and the Warrants constitute
the legal, valid, and binding obligation of the Company enforceable in accordance with its terms, except (a) as limited by applicable
bankruptcy, insolvency, reorganization, moratorium, and other laws of general application affecting enforcement of creditors’
rights generally, and (b) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable
remedies (together, the “Enforceability Exceptions”).

 

(d)              
Consents and Approvals. Except for any Current Report on Form 8-K or Notice of Exempt Offering of Securities on Form
D or other document to be filed by the Company with the U.S. Securities and Exchange Commission (the “SEC”)
in connection with the transactions contemplated hereby, the Company is not required to give any notice to, make any filing with,
or obtain any authorization, consent, or approval of any government or governmental agency in order to consummate the transactions
contemplated hereby. Assuming the accuracy of the representations of the Purchasers in Section 5, no consent, approval,

 

    	 	3	 

     

    

authorization or other order of, or registration,
qualification or filing with, any court, regulatory body, administrative agency, self-regulatory organization, stock exchange or
market (including The NASDAQ Stock Market LLC (“The NASDAQ Stock Market”), or other governmental body is required
for the execution and delivery of the Transaction Agreements, the valid issuance, sale and delivery of the Securities to be sold
pursuant to this Agreement other than such as have been made or obtained, or for any securities filings required to be made under
federal or state securities laws applicable to the offering of the Securities.

 

(e)               
Non-Contravention. The execution and delivery of this Agreement and, following satisfaction of the Closing conditions
set forth in Sections 7 and 8 hereof as applicable to the Closing, the issuance, sale and delivery of the Securities to be sold
by the Company under this Agreement and the performance by the Company of its obligations under the Transaction Agreements and/or
the consummation of the transactions contemplated thereby, will not (a) conflict with, result in the breach or violation of,
or constitute (with or without the giving of notice or the passage of time or both) a violation of, or default under, (i) subject
to obtaining the Pre-Closing Consents, any bond, debenture, note or other evidence of indebtedness, or under any lease, license,
franchise, permit, indenture, mortgage, deed of trust, loan agreement, joint venture or other agreement or instrument to which
the Company or any subsidiary is a party or by which it or its properties may be bound or affected, (ii) the Company’s
Restated Certificate of Incorporation, as amended and as in effect on the date hereof, the Company’s Bylaws, as amended and
as in effect on the date hereof, or the equivalent document with respect to any subsidiary, as amended and as in effect on the
date hereof, or (iii) any statute or law, judgment, decree, rule, regulation, ordinance or order of any court or governmental
or regulatory body (including The NASDAQ Stock Market), governmental agency, arbitration panel or authority applicable to the Company,
any of its subsidiaries or their respective properties, except in the case of clauses (i) and (iii) for such conflicts,
breaches, violations or defaults that would not be likely to have, individually or in the aggregate, a Material Adverse Effect,
or (b) result in the creation or imposition of any lien, encumbrance, claim, security interest or restriction whatsoever upon
any of the material properties or assets of the Company or any of its subsidiaries or an acceleration of indebtedness pursuant
to any obligation, agreement or condition contained in any material bond, debenture, note or any other evidence of indebtedness
or any material indenture, mortgage, deed of trust or any other agreement or instrument to which the Company or any if its subsidiaries
is a party or by which the Company or any of its subsidiaries is bound or to which any of the property or assets of the Company
is subject. For purposes of this Section 4(e), the term “material” shall apply to agreements, understandings, instruments,
contracts or proposed transactions to which the Company is a party or by which it is bound involving obligations (contingent or
otherwise) of, or payments to, the Company in excess of $100,000 in a 12-month period.

 

(f)               
Notes. The Notes have been duly authorized by the Company and, when duly executed and delivered and paid for as provided
herein, will be duly and validly issued and outstanding and will constitute valid and legally binding obligations of the Company
enforceable against the Company in accordance with their terms, subject to the Enforceability Exceptions. Except for the rights
of first investment granted to certain stockholders of the Company pursuant to (i) that certain Letter Agreement dated as of February
23, 2012 by and among the Company and certain of its stockholders, and (ii) the Securities Purchase Agreement dated August 8, 2013
by and among the Company and certain of its stockholders, as amended October 16, 2013 and

 

    	 	4	 

     

    

December 24, 2013 (collectively, the “ROFI
Agreements”), the issuance and delivery of each of the Notes is not subject to preemptive, co-sale, right of first refusal
or any other similar rights of the stockholders of the Company or any other person, or any liens or encumbrances or result in the
triggering of any anti-dilution or other similar rights under any outstanding securities of the Company.

 

(g)              
Authorization of the Warrants. The Warrants have been duly authorized by the Company and, when duly executed and
delivered by the Company, will constitute a valid and binding agreement of the Company, enforceable against the Company in accordance
with its terms, subject to the Enforceability Exceptions.

 

(h)              
Authorization of the Warrant Shares. The Warrant Shares issuable upon exercise of the Warrants have been duly authorized
and reserved for issuance upon exercise by all necessary corporate action (other than the Stockholder Approval) and such shares,
when issued upon such exercise in accordance of the terms of the Warrants, will be validly issued and will be fully paid and non-assessable,
and will be free of any liens or encumbrances with respect to the issuance thereof; provided, however, that the Warrant Shares
shall be subject to restrictions on transfer under state or federal securities laws as set forth in this Agreement, or as otherwise
may be required under state or federal securities laws as set forth in this Agreement at the time a transfer is proposed. Subject
to the Stockholder Approval, the issuance and delivery of the Warrant Shares is not subject to preemptive, co-sale, right of first
refusal or any other similar rights of the stockholders of the Company or any other Person (other than pursuant to the ROFI Agreements),
or any liens or encumbrances or, except in the case where the Company issues Securities that result in the effective issuance of
Common Stock at a price per share less than the then-applicable conversion prices per share for certain outstanding convertible
promissory notes of the Company as separately disclosed to the Purchasers, result in the triggering of any anti-dilution or other
similar rights under any outstanding securities of the Company.

 

(i)                
No Registration. Assuming the accuracy of each of the representations and warranties of the Purchaser herein, the
issuance by the Company of the Securities is exempt from registration under the Securities Act of 1933, as amended (the “Securities
Act”).

 

(j)                
Reporting Status. The Company is subject to the reporting requirements of the Securities Exchange Act of 1934, as
amended (the “Exchange Act”), and, as of the Closing, will have filed all documents and reports that the Company
was required to file pursuant to Section I.A.3.b of the General Instructions to Form S-3 promulgated under the Securities Act in
order for the Company to be eligible to use Form S-3 (the foregoing materials, together with any materials filed by the Company
under the Exchange Act, whether or not required, collectively, the “SEC Documents”). The SEC Documents complied
as to form in all material respects with requirements of the Securities Act and Exchange Act and the rules and regulations of the
SEC promulgated thereunder (collectively, the “SEC Rules”), and none of the SEC Documents and the information
contained therein, as of their respective filing dates, contained any untrue statement of a material fact or omitted to state a
material fact required to be stated therein or necessary in order to make the statements therein, in light of the circumstances
under which they were made, not misleading. As used in this Agreement, “Previously Disclosed” means information
set forth in or incorporated by reference into the SEC Documents filed with the SEC

 

    	 	5	 

     

    

on or after November 9, 2015 but prior to the
date hereof (except for risks and forward-looking information set forth in the “Risk Factors” section of the applicable
SEC Documents or in any forward-looking statement disclaimers or similar statements that are similarly non-specific and are predictive
or forward-looking in nature).

 

(k)              
Legal Proceedings. Except as Previously Disclosed, there is no action, suit or proceeding before any court, governmental
agency or body, domestic or foreign, now pending or, to the knowledge of the Company, threatened against the Company or its subsidiaries
wherein an unfavorable decision, ruling or finding would reasonably be expected to, individually or in the aggregate, (i) materially
adversely affect the validity or enforceability of, or the authority or ability of the Company to perform its obligations under,
the Transaction Agreements or (ii) have a Material Adverse Effect. The Company is not a party to or subject to the provisions
of any injunction, judgment, decree or order of any court, regulatory body, administrative agency or other governmental agency
or body that might have, individually or in the aggregate, a Material Adverse Effect.

 

(l)                
No Violations. Neither the Company nor any of its subsidiaries is in violation of its respective certificate of incorporation,
bylaws or other organizational documents, or to its knowledge, is in violation of any statute or law, judgment, decree, rule, regulation,
ordinance or order of any court or governmental or regulatory body (including The NASDAQ Stock Market), governmental agency, arbitration
panel or authority applicable to the Company or any of its subsidiaries, which violation, individually or in the aggregate, would
be reasonably likely to have a Material Adverse Effect. Neither the Company nor any of its subsidiaries is in default (and there
exists no condition which, with or without the passage of time or giving of notice or both, would constitute a default) in the
performance of any bond, debenture, note or any other evidence of indebtedness in any indenture, mortgage, deed of trust or any
other material agreement or instrument to which the Company or any of its subsidiaries is a party or by which the Company or any
of its subsidiaries is bound or by which the properties of the Company are bound, which would be reasonably likely to have a Material
Adverse Effect. There has not been, and to the knowledge of the Company, there is not pending or contemplated, any investigation
by the SEC involving the Company or any current or former director or officer of the Company and the Company is not an “ineligible
issuer” pursuant to Rules 164, 405 and 433 under the Securities Act. The Company has not received any comment letter from
the SEC relating to any SEC Documents which has not been resolved. The SEC has not issued any stop order or other order suspending
the effectiveness of any registration statement filed by the Company under the Exchange Act or the Securities Act.

 

(m)            
Listing Compliance. The Company is in compliance with the requirements of The NASDAQ Stock Market for continued listing
of the Common Stock thereon and has no knowledge of any facts or circumstances that could reasonably lead to delisting of its Common
Stock from The NASDAQ Stock Market. The Company has taken no action designed to, or likely to have the effect of, terminating the
registration of the Common Stock under the Exchange Act or the listing of the Common Stock on The NASDAQ Stock Market, nor has
the Company received any notification that the SEC or The NASDAQ Stock Market is contemplating terminating such registration or
listing. The transactions contemplated by the Transaction Agreements will not contravene the rules and regulations of The NASDAQ
Stock Market. The Company will comply with all requirements of The NASDAQ Stock Market with

 

    	 	6	 

     

    

respect to the issuance of the Securities, including
the filing of any listing notice with respect to the issuance of the Securities.

 

(n)              
Financial Statements. The consolidated financial statements of the Company and its subsidiaries and the related notes
thereto included in the SEC Documents (the “Financial Statements”) comply in all material respects with applicable
accounting requirements and the rules and regulations of the SEC with respect thereto as in effect at the time of filing and present
fairly, in all material respects, the financial position of the Company and its subsidiaries as of the dates indicated and the
results of its operations and cash flows for the periods therein specified subject, in the case of unaudited statements, to normal
year-end audit adjustments. Except as set forth in such Financial Statements (or the notes thereto), such Financial Statements
(including the related notes) have been prepared in accordance with U.S. generally accepted accounting principles applied on a
consistent basis throughout the periods therein specified (“GAAP”). Except as set forth in the Financial Statements,
neither the Company nor its subsidiaries has any material liabilities other than liabilities and obligations that have arisen in
the ordinary course of business and which would not be required to be reflected in financial statements prepared in accordance
with GAAP.

 

(o)              
Disclosure. The Company understands and confirms that the Purchasers will rely on the foregoing representations in
effecting transactions in the Securities. All disclosure furnished by or on behalf of the Company to the Purchasers in connection
with this Agreement regarding the Company, its business and the transactions contemplated hereby is true and correct in all material
respects and does not contain any untrue statement of a material fact or omit to state any material fact necessary in order to
make the statements made therein, in light of the circumstances under which they were made, not misleading. The Company acknowledges
and agrees that the Purchasers have not made and do not make any representations or warranties with respect to the transactions
contemplated hereby other than those set forth in Section 5 hereto.

 

5.     
Investment Representations. In connection with the receipt of any Securities pursuant to this Agreement
or pursuant to the Notes and Warrants, each Purchaser represents and warrants to the Company the following:

 

(a)               
Organization. Purchaser is duly organized, validly existing, and in good standing under the laws of the jurisdiction
of its organization.

 

(b)              
Power. Purchaser has all requisite power to execute and deliver this Agreement and to carry out and perform its obligations
under the terms of this Agreement.

 

(c)               
Authorization. The execution, delivery, and performance of this Agreement by Purchaser has been duly authorized by
all requisite action, and this Agreement constitutes the legal, valid, and binding obligation of Purchaser enforceable in accordance
with its terms (subject to the Enforceability Exceptions).

 

(d)              
Consents and Approvals. Purchaser need not give any notice to, make any filing with, or obtain any authorization,
consent, or approval of any government or governmental agency in order to consummate the transactions contemplated by this Agreement.

 

    	 	7	 

     

    

(e)               
Non-Contravention. The execution, delivery and, subject to satisfaction by the Company of the conditions to Closing
set forth in Sections 7 and 8 hereof on or prior to the issuance of the Notes and Warrants, or performance, by Purchaser of this
Agreement do not and will not contravene or constitute a default under, or violation of, or be subject to penalties under, (i)
any agreement (or require the consent of any party under any such agreement that has not been made or obtained) to which Purchaser
is a party, or (ii) any judgment, injunction, order, decree or other instrument binding upon Purchaser, except where such contravention,
default, violation or failure to obtain a consent, individually or in the aggregate, would not reasonably be expected to impair
Purchaser’s ability to perform fully any obligation which Purchaser has or will have under this Agreement.

 

(f)               
Investor Qualification. Purchaser understands the definition of the term “accredited investor” within
the meaning of Regulation D, Rule 501(a), promulgated by the SEC under the Securities Act, and qualifies as an accredited
investor.

 

(g)              
Information; Purchase for Investment Only. Purchaser is aware of the Company’s business affairs and financial
condition and has acquired sufficient information about the Company to reach an informed and knowledgeable decision to acquire
the Securities. Purchaser is acquiring the Securities for investment for its own account only and not with a view to, or for resale
in connection with, any “distribution” thereof within the meaning of the Securities Act or under any applicable provision
of state law. Purchaser does not have any present intention to transfer the Securities to any other person or entity in such a
“distribution.”

 

(h)              
No Registration. Purchaser understands that the Securities have not been registered under the Securities Act by reason
of a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature of Purchaser’s
investment intent as expressed herein.

 

(i)                
Restricted Securities. Purchaser understands that the Securities are “restricted securities” under applicable
U.S. federal and state securities laws and that, pursuant to these laws, Purchaser must hold the Securities indefinitely unless
they are registered with the SEC and qualified by state authorities, or an exemption from such registration and qualification requirements
is available. Purchaser acknowledges that the Company has no obligation to register or qualify the Securities for resale.

 

(j)                
Risk of Investment. Purchaser realizes that the purchase of the Securities will be a highly speculative investment
and Purchaser may suffer a complete loss of its investment. Purchaser understands all of the risks related to the purchase of the
Securities. By reason of its business and financial experience, Purchaser has the ability to protect its own interests in connection
with the purchase of the Securities.

 

(k)              
Advisors. Purchaser has reviewed with its own tax advisors the federal, state, and local tax consequences of this
investment and the transactions contemplated by this Agreement. Purchaser acknowledges that it has had the opportunity to review
this Agreement and the transactions contemplated hereby with Purchaser’s own legal counsel.

 

    	 	8	 

     

    

(l)                
Finder. Purchaser is not obligated and will not be obligated to pay any broker commission, finders’ fee, success
fee, or commission in connection with the transactions contemplated by this Agreement.

 

6.     
Restrictive Legends and Stop-Transfer Orders.

 

The Notes and the Warrants and/or the certificate
or certificates representing the Warrant Shares shall bear such legends as the Company deems to be required for the purpose of
compliance with applicable federal or state securities laws or as otherwise required by law.

 

7.     
Conditions to Company’s Obligations at each Closing. The Company’s obligation to complete
the sale and issuance of the Notes and Warrants, and deliver the Notes and Warrants to the Purchasers at each Closing shall be
subject to the following conditions to the extent not waived by the Company:

 

(a)               
Receipt of Payment. The Company shall have received payment (or confirmation that an Irrevocable Payment Instruction
has been made with respect to such payment), by wire transfer of immediately available funds or by cancellation of indebtedness
of the Company to each applicable Purchaser, in the full amount of the Purchase Price for the Notes and Warrants being purchased
by such Purchaser at such Closing.

 

(b)              
Representations and Warranties. The representations and warranties made by the Purchasers in Section 5 hereof
shall be true and correct in all material respects as of, and as if made on, the date of such Closing.

 

8.     
Conditions to Purchaser’s Obligations at each Closing. Each Purchaser’s obligation to accept
delivery of the Notes and Warrants and to pay for such Purchaser’s respective Notes and Warrants at each Closing shall be
subject to the following conditions to the extent not waived by such Purchaser:

 

(a)               
Representations and Warranties. The representations and warranties made by the Company in Section 4 hereof
shall be true and correct in all material respects (except for any representations and warranties which are qualified as to materiality,
which shall be true and correct in all respects) as of, and as if made on, the date of this Agreement and as of the date of such
Closing as though such representations and warranties were made on and as of such date.

 

(b)              
Certificate. The Purchaser shall have received a certificate dated as of the Closing and signed by the Company’s
Chief Executive Officer and Chief Financial Officer to the effect that the representations and warranties of the Company in Section 4
hereof are true and correct in all material respects (except for any representations and warranties which are qualified as to materiality,
which shall be true and correct in all respects) as of, and as if made on, the date of this Agreement and as of such Closing, and
that the Company has satisfied all of the conditions set forth in this Agreement and required to be satisfied as of such Closing.

 

(c)               
Good Standing. The Company shall be validly existing as a corporation in good standing under the laws of Delaware
as evidenced by a certificate of the Secretary of State of the State of Delaware, a copy of which shall be provided to the Purchaser
at the Closing.

 

    	 	9	 

     

    

(d)              
Board Approval. The terms and conditions of the issuance of the Securities (including the issuance of the Warrant
Shares upon issuance thereof) and the Transaction Agreements shall have been duly approved by the Board of Directors of the Company
(including at least six directors who are disinterested with respect to the transactions contemplated hereby).

 

(e)               
Other Approvals. The Company shall have obtained all governmental, regulatory or third party consents and approvals
required in connection with the transactions contemplated hereby, if any, including obtaining the Pre-Closing Consents and any
waivers of any other negative covenants and pro rata or similar preemptive rights that may apply to the issuance of the Securities.

 

9.     
Stockholders Meeting. The Company shall provide each stockholder entitled to vote at a special or annual
meeting of stockholders of the Company (the “Stockholder Meeting”), which initially shall be promptly called
and held not later than June 30, 2016 (the “Stockholder Meeting Deadline”), a proxy statement substantially
in the form which has been previously reviewed by the Purchasers and a counsel of their choice, at the expense of the Company,
soliciting each such stockholder’s affirmative vote at the Stockholder Meeting for approval of resolutions (the “Stockholder
Resolutions”) providing for the Company’s issuance of all of the Securities as described in the Agreement in accordance
with applicable law and rules and regulations of The NASDAQ Stock Market, including the issuance of the Warrant Shares upon exercise
of the Warrants (such affirmative approval being referred to herein as the “Stockholder Approval” and the date
such approval is obtained, the “Stockholder Approval Date”), and the Company shall use its best efforts to solicit
its stockholders’ approval of the Stockholder Resolutions and to cause the Board to recommend to the stockholders that they
approve the Stockholder Resolutions. The Company shall be obligated to seek to obtain the Stockholder Approval by the Stockholder
Meeting Deadline. If, despite the Company’s best efforts, the Stockholder Approval is not obtained on or prior to the Stockholder
Meeting Deadline, the Company shall cause an additional Stockholder Meeting to approve the Stockholder Resolutions to be called
and held at each otherwise convened special or annual meeting of the stockholders of the Company, which special or annual meetings
must be called and held at least once in each six-month period after the Stockholder Meeting Deadline until such Stockholder Approval
is obtained, provided that if the Board does not recommend to the stockholders that they approve the Stockholder Resolutions at
any such Stockholder Meeting and the Stockholder Approval is not obtained, the Company shall cause an additional Stockholder Meeting
to be held each calendar quarter after the Stockholder Meeting Deadline until such Stockholder Approval is obtained.

 

10. 
SEC Filings. Upon execution of this Agreement and the issuances of Notes and Warrants, the Company
will complete any SEC filings (such as a Current Report on Form 8-K and a Notice of Exempt Offering of Securities on Form
D) that are, in the judgment of the Company’s legal counsel, required to be completed.

 

11. 
Miscellaneous.

 

(a)               
Governing Law. This Agreement and all acts and transactions pursuant hereto and the rights and obligations of the
parties hereto shall be governed, construed and

 

    	 	10	 

     

    

interpreted in accordance with the laws
of the State of California, without giving effect to principles of conflicts of law.

 

(b)              
Assignment; Successors and Assigns. This Agreement may not be assigned by the Purchaser without the prior written
consent of the Company; provided, that this Agreement may be assigned by a Purchaser to the valid transferee of any security
purchased hereunder if such security remains a “restricted security” under the Securities Act. This Agreement and all
provisions thereof shall be binding upon, inure to the benefit of, and are enforceable by the parties hereto and their respective
successors and permitted assigns.

 

(c)               
Notices. All notices, requests, and other communications hereunder shall be in writing and will be deemed to have
been duly given and received (i) when personally delivered, (ii) when sent by facsimile upon confirmation of receipt,
(iii) one business day after the day on which the same has been delivered prepaid to a nationally recognized courier service,
or (iv) five business days after the deposit in the United States mail, registered or certified, return receipt requested,
postage prepaid, in each case addressed, as to the Company, to Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, CA 94608,
Attn: General Counsel, facsimile number: , with a copy to Fenwick & West LLP, 801 California Street, Mountain View, CA 94041,
Attn: , facsimile number: , and as to each Purchaser at the address and facsimile number set forth opposite such Purchaser’s
name on the Schedule of Purchasers on Schedule I. Any party hereto from time to time may change its address, facsimile number,
or other information for the purpose of notices to that party by giving notice specifying such change to the other parties hereto.
The Purchasers and the Company may each agree in writing to accept notices and other communications to it hereunder by electronic
communications pursuant to procedures reasonably approved by it; provided that approval of such procedures may be limited to particular
notices or communications.

 

(d)              
Severability. In the event that any provision of this Agreement or the application of any provision hereof is declared
to be illegal, invalid, or otherwise unenforceable by a court of competent jurisdiction, the remainder of this Agreement shall
not be affected except to the extent necessary to delete such illegal, invalid, or unenforceable provision unless that provision
held invalid shall substantially impair the benefits of the remaining portions of this Agreement.

 

(e)               
Headings. The headings in this Agreement are for convenience of reference only and shall not constitute a part of
this Agreement, nor shall they affect its meaning, construction, or effect.

 

(f)               
Entire Agreement. This Agreement embodies the entire understanding and agreement between the parties hereto with
respect to the subject matter hereof and supersedes all prior agreements and understandings relating to the subject matter hereof.

 

(g)              
Expenses. Each party will bear its own costs and expenses in connection with this Agreement.

 

    	 	11	 

     

    

(h)              
Further Assurances. The parties agree to execute and deliver all such further documents, agreements and instruments
and take such other and further action as may be necessary or appropriate to carry out the purposes and intent of this Agreement.

 

(i)                
Counterparts. This Agreement may be executed in two or more counterparts, each of which shall constitute an original,
but all of which, when taken together, shall constitute but one instrument, and shall become effective when one or more counterparts
have been signed by each party hereto and delivered to the other party. Facsimile signatures shall be deemed originals for all
purposes hereunder.

 

(j)                
Amendments and Waivers. This Agreement may not be amended, supplemented or otherwise modified except in a written
instrument executed by the Company and the holders of a majority of the aggregate principal amount of the then outstanding Notes.
No waiver by any of the parties of any default, misrepresentation, or breach of warranty or covenant hereunder, whether intentional
or not, shall be deemed to extend to any prior or subsequent default, misrepresentation, or breach of warranty or covenant hereunder
or affect in any way any rights arising by virtue of any prior or subsequent such occurrence. No waiver by any of the parties of
any of the provisions hereof shall be effective unless explicitly set forth in writing and executed by the party sought to be charged
with such waiver. No action taking pursuant to this Agreement, including any investigation by or on behalf of any party, shall
be deemed to constitute a waiver by the party taking such action of compliance with any representation, warranty, covenant or agreement
contained herein. No failure on the part of any party to exercise, and no delay in exercising, any right, power or remedy hereunder
shall operate as a waiver thereof, nor shall any single or partial exercise of such right, power or remedy by such party preclude
any other or further exercise thereof or the exercise of any other right, power or remedy.

 

[Signature Pages Follow]

 

 

 

 

 

 

 

 

 

 

    	 	12	 

     

    

 

The undersigned has executed this Agreement as of the date first
set forth above.

 

	 	THE COMPANY:	 
	 	 	 
	 	AMYRIS, inc.	 
	 	 	 	 
	 	 	 	 
	 	By:	/s/ John Melo 	 
	 	 	(Signature)	 
	 	Name: 	John Melo 	 
	 	Title: 	President & CEO 	 
	 	 	 	 
	 	Address: 	 	 
	 	5885 Hollis Street, Suite 100	 
	 	Emeryville, CA 94608	 
	 	Attention: General Counsel	 
	 	Facsimile:	 
	 	Email:	 

 

 

 

 

 

 

 

 

 

 

    [Signature Page to Note Purchase Agreement]

     

    

 

The undersigned has executed this Agreement as of the date first
set forth above.

 

	 	PURCHASER:	 
	 	 	 
	 	FORIS VENTURE, LLC	 
	 	 	 	 
	 	 	 	 
	 	/s/ B Hager 	 
	 	(Signature)	 
	 	Name:	Barbara Hager 	 
	 	Title:	Manager 	 

 

 

 

 

 

 

 

 

 

 

 

    [Signature Page to Note Purchase Agreement]

     

    

 

The undersigned has executed this Agreement as of the date first
set forth above.

 

	 	PURCHASER:	 
	 	 	 	 	 
	 	NAXYRIS S.A.    	 
	 	 	 	 	 
	 	 	 	 	 
	 	 	/s/ Christoph Piel	/s/ Jacques Reckinger	 
	 	(Signature)	 
	 	Name: 	Christoph PIEL	Jacques RECKINGER	 
	 	Title:	Director	Director 	 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

    [Signature Page to Note Purchase Agreement]

     

    

 

The undersigned has executed this Agreement as of the date first
set forth above.

 

	 	PURCHASER:	 
	 	BIOLDING INVESTMENT SA
	 	 	 	 
	 	 	 	 
	 	/s/  HH Sheik Abdullah bin Khalifa Al Thani 	 
	 	(Signature)	 
	 	Name: 	 	 
	 	Title: 	 	 

 

 

 

 

 

 

 

 

 

 

 

 

 

    [Signature Page to Note Purchase Agreement]

     

    

 

Schedule
I

 

Schedule of Purchasers

 

Initial Closing: February 12, 2016

 

	Name of Purchaser	Notes Principal Amount	Note Purchase Price	Warrant Shares	Warrant Purchase Price	Address and Facsimile
	
        Foris Ventures LLC

         
	$16,000,000.00	$12,822,857.54	2,285,714	$3,177,142.46	
        Foris Ventures LLC

        Attention: Barbara S. Hager

        JEMA Management LLC

        555 Bryant Street, No. 722

        Palo Alto, CA 94301

        Phone:

        Fax:

         

	Biolding Investment S.A.	$2,000,000.00	$1,602,857.54	285,714	$397,142.46	
        Biolding Investment S.A.

        11 A Boulevard du Prince Henri

        L-1724 Luxembourg

        Facsimile:

         

	TOTAL	$18,000,000.00	
        $14,425,715.08

         
	
        2,571,428

         
	
        $3,574,284.92

         
	 

 

 

 

 

     

     

    

 

Additional Closing: February 15, 2016

 

	Name of Purchaser	Notes Principal Amount	Note Purchase Price	Warrant Shares	Warrant Purchase Price	Address and Facsimile
	
        Naxyris S.A.

         
	$2,000,000.00	$1,602,857.54	285,714	$397,142.46	
        Naxyris S.A.

        Attention: Sam Reckinger and Chirstoph Piel

        40, Boulevard Jospeh II

        L-1840, Luxembourg

        Facsimile:

        Email:

         

	TOTAL	$2,000,000.00	$1,602,857.54	285,714	$397,142.46	 

 

 

 

 

 

 

 

 

 

 

 

 

     

     

    

 

exhibit
a

 

form of note

UNSECURED PROMISSORY
NOTE

 

	U.S.$____________	Issue Date: February __, 2016

 

THE SECURITIES REPRESENTED BY THIS NOTE AND THE SECURITIES THAT
MAY BE ISSUED AS REPAYMENT FOR THIS NOTE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”),
OR APPLICABLE STATE SECURITIES LAWS, AND MAY NOT BE OFFERED, SOLD, ASSIGNED, PLEDGED, TRANSFERRED OR OTHERWISE DISPOSED OF IN THE
ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER THE ACT AND APPLICABLE STATE SECURITIES LAWS OR PURSUANT TO AN AVAILABLE EXEMPTION
FROM REGISTRATION UNDER THE ACT OR SUCH LAWS AND, IF REASONABLY REQUESTED BY THE COMPANY, UPON DELIVERY OF AN OPINION OF COUNSEL
REASONABLY SATISFACTORY TO THE COMPANY THAT THE PROPOSED TRANSFER IS EXEMPT FROM THE ACT OR SUCH LAWS.

 

Subject to the terms and conditions of this
Note, for value received, Amyris, Inc., a Delaware corporation (the “Company”), hereby promises to pay
to the order of [Investor Name] or registered assigns (“Holder”),
the principal sum of [Investment Amount] Dollars ($_________),
or such lesser amount as shall then equal the outstanding principal amount hereunder, together with interest accrued on the unpaid
principal amount at the Applicable Rate. Interest shall begin to accrue on the Issue Date set forth above, shall continue to accrue
on the outstanding principal until the entire Balance is paid, and shall be computed based on the actual number of days elapsed
and on a year of 365 days.

 

This Note was issued pursuant to the Note and
Warrant Purchase Agreement, dated as of February 12, 2016 (as amended from time to time, the “Agreement”),
by and among the Company, the original holder of this Note and the other parties thereto and is subject to provisions of the Agreement.

 

The following is a statement of the rights of
Holder and the terms and conditions to which this Note is subject, and to which the Holder hereof, by the acceptance of this Note,
agrees.

 

1.                 
DEFINITION. The following definitions shall apply for purposes of this Note.

 

“Affiliate” has the
meaning ascribed to it in Rule 144 promulgated under the Securities Act.

 

“Applicable Rate”
means a rate equal to the lower of: (a) the Highest Lawful Rate; and (b) thirteen and a half percent (13.50%) per annum.

 

“Balance” means, at
the applicable time, the sum of all then outstanding principal of this Note, all then accrued but unpaid interest and all other
amounts then accrued but unpaid under

 

this Note.

 

     

     

    

“Board of Directors”
means the Company’s Board of Directors.

 

“Business Day” means
a weekday on which banks are open for general banking business in San Francisco, California.

 

“Change of Control”
shall mean the occurrence of any of the following: (i) the consolidation of the Company with, or the merger of the Company
with or into, another “person” (as such term is used in Rule 13d-3 and Rule 13d-5 of the Exchange Act), or the sale,
lease, transfer, conveyance or other disposition, in one or a series of related transactions, of all or substantially all of the
assets of the Company and its Subsidiaries taken as a whole, or the consolidation of another “person” with, or the
merger of another “person” into, the Company, other than in each case pursuant to a transaction in which the “persons”
that “beneficially owned” (as such term is defined in Rule 13d-3 and Rule 13d-5 under the Exchange Act), directly or
indirectly, the Voting Shares of the Company immediately prior to the transaction “beneficially own”, directly or indirectly,
Voting Shares representing at least a majority of the total voting power of all outstanding classes of voting stock of the surviving
or transferee person; (ii) the adoption by the Company of a plan relating to the liquidation or dissolution of the Company;
(iii) the consummation of any transaction (including, without limitation, any merger or consolidation) the result of which
is that any “person” becomes the “beneficial owner” directly or indirectly, of more than 50% of the Voting
Shares of the Company (measured by voting power rather than number of shares); or (iv) the first day on which a majority of
the members of the Board of Directors does not consist of Continuing Directors.

 

“Company” shall include,
in addition to the Company identified in the opening paragraph of this Note, any corporation or other entity which succeeds to
the Company’s obligations under this Note, whether by permitted assignment, by merger or consolidation, operation of law
or otherwise.

 

“Continuing Director”
shall mean, as of any date of determination, any member of the Board of Directors who (i) was a member of the Board of Directors
on the Issue Date or (ii) was nominated for election or elected to the Board of Directors with the approval of a majority
of the Continuing Directors who were members of the Board of Directors at the time of such nomination or election and who voted
with respect to such nomination or election; provided that a majority of the members of the Board of Directors voting with respect
thereto shall at the time have been Continuing Directors.

 

“Event of Default” has
the meaning set forth in Section 5.

 

“Financing Document” means
each of this Note, the Notes, the Agreement and any other document entered into, executed or delivered under or in connection with,
or for the purpose of amending, any of such documents.

 

“Highest Lawful Rate”
means the maximum non-usurious rate of interest, as in effect from time to time, which may be charged, contracted for, reserved,
received or collected by Holder in connection with this Note under applicable law.

 

    	 	- 2 -	 

     

    

“Lost Note Documentation”
means documentation satisfactory to the Company with regard to a lost or stolen Note, including, if required by the Company, an
affidavit of lost note and an indemnification agreement by Holder in favor of the Company with respect to such lost or stolen Note.

 

“Maturity Date” means
May 15, 2017.

 

“Note” means this
Unsecured Promissory Note.

 

“Notes” means a series
of unsecured promissory notes aggregating up to no more than $20,000,000 in original principal amount issued under the Agreement,
of which this Note is one, each such note containing substantially identical terms and conditions as this Note.

 

“Person” means an
individual, corporation, limited liability company, partnership, association, joint-stock company, trust, unincorporated organization,
joint venture or other entity or any governmental authority.

 

“Principal Balance”
means, at the applicable time, all then outstanding principal of this Note.

 

“Subsidiary” means,
with respect to any specified Person: (a) any corporation, association or other business entity of which more than 50% of the total
voting power of shares of capital stock entitled (without regard to the occurrence of any contingency and after giving effect to
any voting agreement or stockholders’ agreement that effectively transfers voting power) to vote in the election of directors,
managers or trustees of the corporation, association or other business entity is at the time owned or controlled, directly or indirectly,
by that Person or one or more of the other Subsidiaries of that Person (or a combination thereof); and (b) any partnership (i)
the sole general partner or the managing general partner of which is such Person or a Subsidiary of such Person or (ii) the only
general partners of which are that Person or one or more Subsidiaries of that Person (or any combination thereof).

 

“Voting Shares” of
any person means capital shares or capital stock of such Person which ordinarily has voting power for the election of directors
(or persons performing similar functions) of such person, whether at all times or only so long as no senior class of securities
has such voting power by reason of any contingency.

 

2.                 
PAYMENT AT MATURITY DATE; INTEREST. 

 

2.1             
Payment at Maturity Date.

 

(a)              
If this Note has not been previously prepaid pursuant to Section 3.1 prior to the Maturity Date, then the entire Balance
shall be due and payable in full in cash on the Maturity Date.

 

(b)              
All rights with respect to this Note shall terminate upon the repayment of the entire Balance of this Note as provided
in Section 2.1(a). Notwithstanding the foregoing, Holder agrees to surrender this Note to the Company (or Lost Note Documentation
where applicable) as soon as practicable after repayment pursuant to Section 2.1.

 

    	 	- 3 -	 

     

    

(c)               
Notwithstanding anything herein to the contrary, if during any period for which interest is computed hereunder, the
amount of interest computed on the basis provided for in this Note, together with all fees, charges and other payments which are
treated as interest under applicable law, as provided for herein or in any other document executed in connection herewith, would
exceed the amount of such interest computed on the basis of the Highest Lawful Rate, then the Company shall not be obligated to
pay, and Holder shall not be entitled to charge, collect, receive, reserve or take, interest in excess of the Highest Lawful Rate,
and during any such period the interest payable hereunder shall be computed on the basis of the Highest Lawful Rate. 

 

3.                 
Prepayment; Change of control.

 

3.1             
Prepayment. The Company may at any time, without penalty, upon at least five (5) days’ advance written
notice to Holder, prepay all or any portion of the unpaid Balance of this Note. Any such prepayment shall be applied as provided
in Section 4 below. 

 

3.2             
Change of Control Payment. If the Company completes a Change of Control before the payment of the entire Balance
of this Note, then upon the closing of such Change of Control, Holder shall be entitled to be repaid the entire Balance of this
Note.

 

4.                 
Notes Pari Passu; APPLICATION OF PAYMENTS. Each of the Notes shall rank equally without preference or
priority of any kind over one another, and all payments and recoveries under any other Financing Document payable on account of
principal and interest on the Notes shall be paid and applied ratably and proportionately on the Balances of all outstanding Notes
on the basis of their original principal amount. Subject to the foregoing provisions of this Section, all payments will be applied
first to the repayment of accrued fees and expenses under this Note, then to accrued interest until all then
outstanding accrued interest has been paid in full, and then to the repayment of principal until all principal has been
paid in full. If after all applications of such payments have been made as provided in this Section, then the remaining amount
of such payment that are in either case in excess of the aggregate Balance of all outstanding Notes, shall be returned to the Company.

 

5.                 
EVENTS OF DEFAULT. Each of the following events shall constitute an “Event of Default”
hereunder:

 

(a)              
The Company fails to make any payment when due under this Note on the applicable due date or within five (5) days after
written notice of such failure has been given on behalf of Holder to the Company;

 

(b)              
A receiver is appointed for any material part of the Company’s property, the Company makes a general assignment
for the benefit of creditors, or the Company becomes a debtor or alleged debtor in a case under the U.S. Bankruptcy Code or becomes
the subject of any other bankruptcy or similar proceeding for the general adjustment of its debts or for its liquidation;

 

(c)                   
The Company breaches any material obligation to any Holder under this Note and does not cure such breach within twenty
(20) days after written notice thereof has been given by or on behalf of such Holder to the Company; or

 

    	 	- 4 -	 

     

    

(d)                  
The Company’s Board of Directors or stockholders adopt a resolution for the liquidation, dissolution or winding
up of the Company.

 

Upon the occurrence of any Event of Default, all accrued but unpaid
expenses, accrued but unpaid interest, all principal and any other amounts outstanding under this Note shall (i) in the case of
any Event of Default under Section 5(b), become immediately due and payable in full without further notice or demand by Holder
and (ii) in the case of any Event of Default other than under Section 5(b), become immediately due and payable upon written notice
by or on behalf of all Holder(s) of then outstanding Notes.  Notwithstanding any other provision of this Note, Holder agrees
that Holder will exercise Holder’s rights and remedies under this Note only in concert with all other holders of outstanding
Notes and will not take any action, including commencement or prosecution of litigation or any other proceeding to collect this
Note, except as agreed by the holders of a majority of the then outstanding principal amount of the Notes.

 

6.                 
PROVISIONS RELATING TO Stockholder RIGHTS. This Note does not entitle Holder to any voting rights or other
rights as a stockholder of the Company. No provisions of this Note and no enumeration herein of the rights or privileges of Holder,
shall cause Holder to be a stockholder of the Company for any purpose.

 

7.                 
REPRESENTATIONS AND WARRANTIES OF HOLDER. In order to induce the Company to issue this Note to the original
Holder, the original Holder has made representations and warranties to the Company as set forth in the Agreement.

 

8.                 
GENERAL PROVISIONS.

 

8.1             
Waivers. The Company and all endorsers of this Note hereby waive notice, presentment, protest and notice of dishonor.

 

8.2             
Transfer. Neither this Note nor any rights hereunder may be assigned, conveyed or transferred, in whole or in
part, without the Company’s prior written consent, which the Company may withhold in its sole discretion; provided,
however, that this Note may be assigned, conveyed or transferred without the prior written consent of the Company to
any Affiliate of Holder who (a) executes and delivers an acknowledgement that such transferee agrees to be subject to, and
bound by, all the terms and conditions of this Note, (b) makes the representations and warranties to the Company that are set forth
in Section 5 of the Agreement, and (c) (if requested by the Company) delivers to the Company an opinion of legal counsel,
reasonably satisfactory to the Company, that such transfer complies with state and federal securities laws. Subject to the foregoing,
the rights and obligations of the Company and Holder under this Note shall be binding upon and benefit their respective permitted
successors, assigns, heirs, administrators and transferees.

 

8.3             
Governing Law. This Note shall be governed, construed and interpreted in accordance with the laws of the State
of California, without giving effect to principles of conflicts of law.

 

8.4             
Headings. The headings and captions used in this Note are used only for convenience and are not to be considered
in construing or interpreting this Note. All references

 

    	 	- 5 -	 

     

    

in this Note to sections and exhibits shall, unless
otherwise provided, refer to sections hereof and exhibits attached hereto, all of which exhibits are incorporated herein by this
reference.

 

8.5             
Notices. All notices, requests, and other communications hereunder shall be in writing and will be deemed to
have been duly given and received (a) when personally delivered, (b) when sent by facsimile upon confirmation of receipt,
(c) one business day after the day on which the same has been delivered prepaid to a nationally recognized courier service,
or (d) five business days after the deposit in the United States mail, registered or certified, return receipt requested,
postage prepaid, in each case addressed, as to the Company, to Amyris, Inc., 5885 Hollis Street, Suite 100, Emeryville, CA 94608,
Attn: General Counsel, facsimile number: , with a copy to Fenwick & West LLP, 801 California Street, Mountain View, CA 94041,
Attn: , facsimile number: , and as to Holder at the address and facsimile number set forth opposite such Holder’s name on
Schedule I to the Agreement or as otherwise indicated by Holder by providing notice of a change in its address, facsimile
number, or other information to the Company. Holder and the Company may each agree in writing to accept notices and other communications
to it hereunder by electronic communications pursuant to procedures reasonably approved by it; provided that approval of such procedures
may be limited to particular notices or communications.

 

8.6             
Place of Payment. Payments of the Principal and any interest and other payments hereunder shall be delivered
to the Holder at the address specified in the Agreement or at such other address or the attention of such other person as specified
by prior written notice to the Company, including any transferee of this Note.

 

8.7             
Amendments and Waivers. This Note and all other Notes issued under
the Agreement may be amended and provisions may be waived by the Note holders holding at least a majority of the then outstanding
principal amount of Notes and the Company as provided in Section 11(j) of the Agreement. Any amendment or waiver effected
in accordance with Section 11(j) of the Agreement shall be binding upon each holder of any Notes at the time outstanding, each
future holder of the Notes and the Company.

 

8.8             
Severability. If one or more provisions of this Note are held to be unenforceable under applicable law, then
such provision(s) shall be excluded from this Note to the extent they are held to be unenforceable and the remainder of the Note
shall be interpreted as if such provision(s) were so excluded and shall be enforceable in accordance with its terms.

 

[Signature page
follows]

 

 

 

 

 

 

 

 

 

 

 

 

    	 	- 6 -	 

     

    

 

IN WITNESS WHEREOF, the Company has caused this Unsecured
Promissory Note to be signed in its name as of the date first written above.

 

	 	THE COMPANY	 
	 	AMYRIS, INC.	 
	 	 	 	 
	 	 	 	 
	 	By: 	 	 
	 	Name:  	 	 
	 	Title 	 	 

 

 

 

 

 

 

 

 

 

 

 

 

 

     

     

    

exhibit
B

 

FORM OF WARRANT

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

    	 	- 2 -	 

     

    

 

NEITHER THE ISSUANCE AND SALE OF THE SECURITIES
REPRESENTED BY THIS CERTIFICATE NOR THE SECURITIES INTO WHICH THESE SECURITIES ARE EXERCISABLE HAVE BEEN REGISTERED UNDER THE SECURITIES
ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY NOT BE OFFERED FOR SALE, SOLD, TRANSFERRED
OR ASSIGNED (I) IN THE ABSENCE OF (A) AN EFFECTIVE REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT OF 1933,
AS AMENDED (THE “SECURITIES ACT”), OR (B) AN OPINION OF COUNSEL TO THE HOLDER (IF REQUESTED BY THE COMPANY), IN
A FORM REASONABLY ACCEPTABLE TO THE COMPANY, THAT REGISTRATION IS NOT REQUIRED UNDER SAID ACT OR (II) UNLESS SOLD OR ELIGIBLE TO
BE SOLD PURSUANT TO RULE 144 UNDER SAID ACT. NOTWITHSTANDING THE FOREGOING, THE SECURITIES MAY BE PLEDGED IN CONNECTION WITH A
BONA FIDE MARGIN ACCOUNT OR OTHER LOAN OR FINANCING ARRANGEMENT SECURED BY THE SECURITIES.

 

WARRANT TO PURCHASE STOCK

 

	Company:	 	Amyris, Inc., a Delaware corporation
	Warrant Certificate:	 	W-
	Number of Shares:	 	[●]
	Class of Stock:	 	Common Stock
	Warrant Price:	 	$0.01 per share
	Issue Date:	 	___________, 2016
	Expiration Date:	 	The 5th anniversary after the Issue Date

 

 

THIS WARRANT CERTIFIES THAT, for good and valuable
consideration, [INSERT INVESTOR NAME] (together with any registered holder from
time to time of this Warrant or any holder of the shares issuable or issued upon exercise of this Warrant, “Holder”)
is entitled to purchase the number of fully paid and nonassessable shares of the class of securities of the Company at the Warrant
Price, all as set forth above and as adjusted pursuant to Article 2 of this Warrant, subject to the provisions and upon the terms
and conditions set forth in this Warrant. This Warrant is issued in connection with the Note and Warrant Purchase Agreement between
Company and the Purchasers (as defined therein) dated as of February 12, 2016, as amended from time to time (the “Purchase
Agreement”). Capitalized terms used but not otherwise defined herein shall have the meaning ascribed to them in the Purchase
Agreement.

 

ARTICLE
1 EXERCISE.

 

1.1.           
Conditions to Exercise. Holder may not exercise this Warrant unless and
until this Warrant has been approved by a majority of the Company’s stockholders whose vote was counted at the Stockholders
Meeting (the “Exercise Condition”). Upon satisfaction of the Exercise Condition and thereafter, this Warrant
shall be exercisable for [●] shares of the Company’s Common Stock (subject to adjustment as provided herein) (the “Shares”).
The number of Shares and the Warrant Price are subject to adjustment as provided herein, and all references to “Shares”
and “Warrant Price” herein shall be deemed to include any such adjustment or series of adjustments.

 

     

     

    

1.2.           
Method of Exercise.

 

(a)              
Mechanics. This Warrant may be exercised by the Holder on any day on or after the date the Exercise Condition
has been satisfied (an “Exercise Date”), in whole or in part, by delivery (whether via facsimile or otherwise)
of a written notice, in the form attached hereto as Exhibit A (the “Exercise Notice”), of the Holder’s
election to exercise this Warrant. Within one (1) Trading Day following an exercise of this Warrant as aforesaid, the Holder shall
deliver payment to the Company of an amount equal to the Exercise Price in effect on the date of such exercise multiplied by the
number of Shares as to which this Warrant was so exercised (the “Aggregate Exercise Price”) in cash or via wire
transfer of immediately available funds if the Holder did not notify the Company in such Exercise Notice that such exercise was
made pursuant to a Cashless Exercise (as defined in Section 1.3). The Holder shall not be required to deliver the original of this
Warrant in order to effect an exercise hereunder. Execution and delivery of an Exercise Notice with respect to less than all of
the Shares shall have the same effect as cancellation of the original of this Warrant and issuance of a new Warrant evidencing
the right to purchase the remaining number of Shares. Execution and delivery of an Exercise Notice for all of the then-remaining
Shares shall have the same effect as cancellation of the original of this Warrant after delivery of the Shares in accordance with
the terms hereof. On or before the third (3rd) Trading Day following the date on which the Company has received such Exercise Notice,
the Company shall (X) provided that the Transfer Agent is participating in The Depository Trust Company (“DTC”)
Fast Automated Securities Transfer Program, upon the request of the Holder, credit such aggregate number of shares of Common Stock
to which the Holder is entitled pursuant to such exercise to the Holder’s or its designee’s balance account with DTC
through its Deposit/Withdrawal at Custodian system, or (Y) if the Transfer Agent is not participating in the DTC Fast Automated
Securities Transfer Program, upon the request of the Holder, issue and deliver (via reputable overnight courier) to the address
as specified in the Exercise Notice, a certificate, registered in the name of the Holder or its designee, for the number of shares
of Common Stock to which the Holder shall be entitled pursuant to such exercise. Upon delivery of an Exercise Notice, the Holder
shall be deemed for all corporate purposes to have become the holder of record of the Shares with respect to which this Warrant
has been exercised, irrespective of the date such Shares are credited to the Holder’s DTC account or the date of delivery
of the certificates evidencing such Shares (as the case may be). If this Warrant is submitted in connection with any exercise pursuant
to this Section 1 and the number of Shares represented by this Warrant submitted for exercise is greater than the number of Shares
being acquired upon an exercise and upon surrender of this Warrant to the Company by the Holder, then, at the request of the Holder,
the Company shall as soon as practicable and in no event later than three (3) Business Days after any exercise and at its own expense,
issue and deliver to the Holder (or its designee) a new Warrant representing the right to purchase the number of Shares purchasable
immediately prior to such exercise under this Warrant, less the number of Shares with respect to which this Warrant is exercised.
No fractional shares of Common Stock are to be issued upon the exercise of this Warrant, but rather the number of shares of Common
Stock to be issued shall be rounded down to the nearest whole number. The Company shall pay any and all transfer, stamp, issuance
and similar taxes, costs and expenses (including, without limitation, fees and expenses of the Transfer Agent) that may be payable
with respect to the issuance and delivery of Shares upon exercise of this Warrant. Notwithstanding the foregoing, except in the
case where an exercise of this Warrant is validly made pursuant to a Cashless Exercise), the Company’s failure to deliver
Shares to the Holder on or prior to the later of ((i) three (3) Trading

 

    	 	2	 

     

    

Days after receipt of the applicable Exercise
Notice and (ii) one (1) Trading Day after the Company’s receipt of the Aggregate Exercise Price (or valid notice of a Cashless
Exercise (such later date, the “Share Delivery Deadline”) shall not be deemed to be a breach of this Warrant.

 

(b)              
Company’s Failure to Timely Deliver Securities. If the Company shall fail, for any reason or for
no reason, on or prior to the Share Delivery Deadline, if the Transfer Agent is not participating in the DTC Fast Automated Securities
Transfer Program, to issue and deliver to the Holder (or its designee) a certificate for the number of Shares to which the Holder
is entitled and register such Shares on the Company’s share register or, if the Transfer Agent is participating in the DTC
Fast Automated Securities Transfer Program, to credit the balance account of the Holder or the Holder’s designee with DTC
for such number of Shares to which the Holder is entitled upon the Holder’s exercise of this Warrant (as the case may be),
and if on or after such Share Delivery Deadline the Holder purchases (in an open market transaction or otherwise) shares of Common
Stock to deliver in satisfaction of a sale by the Holder of all or any portion of the number of shares of Common Stock issuable
upon such exercise that the Holder anticipated receiving from the Company (a “Buy-In”), then, in addition to
all other remedies available to the Holder, the Company shall, within three (3) Business Days after the Holder’s request
and in the Holder’s discretion, either (i) pay cash to the Holder in an amount equal to the Holder’s total purchase
price (including brokerage commissions and other out-of-pocket expenses, if any) for the shares of Common Stock so purchased (including,
without limitation, by any other Person in respect, or on behalf, of the Holder) (the “Buy-In Price”), at which
point the Company’s obligation to so issue and deliver such certificate (and to issue such shares of Common Stock) or credit
the balance account of such Holder or such Holder’s designee, as applicable, with DTC for the number of Shares to which the
Holder is entitled upon the Holder’s exercise hereunder (as the case may be) (and to issue such Shares) shall terminate,
or (ii) promptly honor its obligation to so issue and deliver to the Holder a certificate or certificates representing such Shares
or credit the balance account of such Holder or such Holder’s designee, as applicable, with DTC for the number of Shares
to which the Holder is entitled upon the Holder’s exercise hereunder (as the case may be) and pay cash to the Holder in an
amount equal to the excess (if any) of the Buy-In Price over the product of (A) such number of Shares multiplied by (B) the lowest
Closing Sale Price of the Common Stock on any Trading Day during the period commencing on the date of the applicable Exercise Notice
and ending on the date of such issuance and payment under this clause (ii). Nothing shall limit the Holder’s right to pursue
any other remedies available to it hereunder, at law or in equity, including, without limitation, a decree of specific performance
and/or injunctive relief with respect to the Company’s failure to timely deliver certificates representing shares of Common
Stock (or to electronically deliver such shares of Common Stock) upon the exercise of this Warrant as required pursuant to the
terms hereof.

 

1.3.           
Cashless Exercise Right. In lieu of exercising this Warrant as specified in Article 1.2, Holder may from
time to time, following satisfaction of the Exercise Condition , in its sole discretion, exercise this Warrant in whole or in part
and, in lieu of making the cash payment otherwise contemplated to be made to the Company upon such exercise in payment of the aggregate
Warrant Price pursuant to Article 1.2, elect instead to receive upon such exercise the “Net
Number” of shares of Common Stock determined according to the following formula (a “Cashless Exercise”):

 

    	 	3	 

     

    

 

	 	Net Number =	(A x B) - (A x C)	 
	 	 	B	 

 

For purposes of the foregoing formula:

 

A= the total number of shares with respect to which this Warrant
is then being exercised.

 

B= the fair market value of each Share
shall be the average for the five Trading Days immediately prior to the date of determination thereof of the last reported sale
price regular way on each such day, or, in the case no such sale takes place on any such day, the average of the reported closing
bid and asked prices regular way of the shares of Common Stock on such day, in each case as quoted on the Principal Market, as
reported by Bloomberg or such other principal securities exchange or inter-dealer quotation system on which the shares of Common
Stock are then traded.

 

C= the Warrant Price then in effect for the applicable Shares at the time
of such exercise.

 

1.4.           
Delivery of Certificate and New Warrant. Promptly after Holder exercises or converts this Warrant, and,
if applicable, the Company receives payment of the aggregate Warrant Price, the Company shall deliver to Holder certificates for
the Shares acquired and, if this Warrant has not been fully exercised or converted and has not expired, a new Warrant representing
the Shares not so acquired. Holder shall be deemed to own and have all of the rights associated with any Shares or other securities
or property to which it is entitled pursuant to this Warrant upon the exercise or conversion of the Warrant in accordance with
this Article 1.

 

1.5.           
Replacement of Warrants. On receipt of evidence reasonably satisfactory to the Company of the loss, theft,
destruction or mutilation of this Warrant and in the case of loss, theft or destruction, on delivery of an indemnity agreement
reasonably satisfactory in form and amount to the Company or, in the case of mutilation on surrender and cancellation of this Warrant,
the Company shall execute and deliver, in lieu of this Warrant, a new warrant of like tenor.

 

1.6.           
Treatment of Warrant Upon Acquisition of Company.

 

1.6.1       
“Acquisition”. For the purpose of this Warrant, “Acquisition” shall mean the occurrence
of any of the following: (i) the consolidation of the Company with, or the merger of the Company with or into, another “person”
(as such term is used in Rule 13d-3 and Rule 13d-5 of the Exchange Act), or the sale, lease, transfer, conveyance or other disposition,
in one or a series of related transactions, of all or substantially all of the assets of the Company and its Subsidiaries taken
as a whole, or the consolidation of another “person” with, or the merger of another “person” into, the
Company, other than in each case pursuant to a transaction in which the “persons” that “beneficially owned”
(as such term is defined in Rule 13d-3 and Rule 13d-5 under the Exchange Act), directly or indirectly, the Voting Shares (as defined
below) of the Company immediately prior to the transaction “beneficially own”, directly or indirectly, Voting Shares
representing at least a majority of the total voting power of all outstanding classes of voting stock of the surviving or transferee
person; (ii) the adoption by the Company of a plan relating to the liquidation or dissolution of the Company; (iii) the
consummation of any

 

    	 	4	 

     

    

transaction (including, without limitation, any
merger or consolidation) the result of which is that any “person” becomes the “beneficial owner” directly
or indirectly, of more than 50% of the Voting Shares of the Company (measured by voting power rather than number of shares); or
(iv) the first day on which a majority of the members of the Company’s Board of Directors (the “Board”)
does not consist of Continuing Directors (as defined below). For the purposes of this Article 1.7.1, (i) “Voting Shares”
of any person shall mean capital shares or capital stock of such person which ordinarily has voting power for the election of directors
(or persons performing similar functions) of such person, whether at all times or only so long as no senior class of securities
has such voting power by reason of any contingency, and (ii) “Continuing Director” shall mean, as of any date of determination,
any member of the Board who (i) was a member of the Board on the Issue Date or (ii) was nominated for election or elected to the
Board with the approval of a majority of the Continuing Directors who were members of the Board at the time of such nomination
or election and who voted with respect to such nomination or election; provided that a majority of the members of the Board voting
with respect thereto shall at the time have been Continuing Directors.

 

1.6.2       
Treatment of Warrant at Acquisition. In the event of an Acquisition, either (a) Holder shall exercise
or convert his Warrant in full with respect to all remaining Shares for which the Warrant is then exercisable and such exercise
or conversion will be deemed effective immediately prior to the consummation of such Acquisition or (b) if Holder elects not to
exercise or convert the Warrant, this Warrant will expire upon the consummation of such Acquisition. The Company shall provide
Holder with written notice of the foregoing (together with such reasonable information as Holder may request in connection with
such contemplated Acquisition giving rise to such notice), which is to be delivered to Holder not less than ten (10) days prior
to the closing of the proposed Acquisition.

 

1.7.           
Insufficient Authorized Shares. If at any time while the Warrant remains outstanding the Company does
not have a sufficient number of authorized and unreserved shares of Common Stock to satisfy its obligation to reserve for issuance
upon exercise of the Warrant at least a number of shares of Common Stock equal to 100% (the “Required Reserve Amount”)
of the number of shares of Common Stock as shall from time to time be necessary to effect the exercise of the Warrant then outstanding,
then the Company shall immediately take all action necessary to increase the Company’s authorized shares of Common Stock
to an amount sufficient to allow the Company to reserve the Required Reserve Amount for the Warrant then outstanding.

 

ARTICLE
2 ADJUSTMENTS TO THE SHARES.

 

2.1.           
Stock Dividends, Splits, Etc. If the Company declares or pays a dividend on the Shares payable in common
stock of the Company, or other securities, then upon exercise of this Warrant, for each Share acquired, Holder shall receive, without
cost to Holder, the total number and kind of shares of common stock of the Company to which Holder would have been entitled had
Holder owned the Shares of record as of the date the dividend occurred. If the Company subdivides the Shares by reclassification
or otherwise into a greater number of shares or takes any other action which increases the amount of stock for which this Warrant
is exercisable, the number of Shares subject to the Warrant shall be proportionately increased and the Warrant Price shall be proportionately
decreased. If the outstanding shares are combined or consolidated, by

 

    	 	5	 

     

    

reclassification or otherwise, into a lesser number
of shares, the Warrant Price shall be proportionately increased and the number of Shares subject to the Warrant shall be proportionately
decreased.

 

2.2.           
Reclassification, Exchange, Combinations or Substitution. Upon any reclassification, exchange, substitution,
or other event that results in a change of the number and/or class of the securities issuable upon exercise or conversion of this
Warrant (other than an Acquisition which is subject to the provisions of Article 1.6), Holder shall be entitled to receive, upon
exercise or conversion of this Warrant the number and kind of securities and property that Holder would have received for the Shares
if this Warrant had been exercised immediately before such reclassification, exchange, substitution, or other event. The Company
or its successor shall promptly issue to Holder an amendment to this Warrant setting forth the number and kind of such new securities
or other property issuable upon exercise or conversion of this Warrant as a result of such reclassification, exchange, substitution
or other event that results in a change of the number and/or class of securities issuable upon exercise or conversion of this Warrant.
The amendment to this Warrant shall provide for adjustments which shall be as nearly equivalent as may be practicable to the adjustments
provided for in this Article 2 including, without limitation, adjustments to the Warrant Price and to the number of securities
or property issuable upon exercise of the new Warrant. The provisions of this Article 2.2 shall similarly apply to successive reclassifications,
exchanges, substitutions, or other events.

 

2.3.           
Rights Upon Distribution of Assets. If the Company shall declare or make any dividend or other distribution
of its assets (or rights to acquire its assets) to holders of shares of Common Stock (which dividend or other distribution has
not already been given to the Holder of the Warrant), by way of return of capital or otherwise (including, without limitation,
any distribution of cash, stock or other securities, property or options by way of a dividend, spin off, reclassification, corporate
rearrangement, scheme of arrangement or other similar transaction) (a “Distribution”), at any time after the issuance
of this Warrant and prior to the Expiration Date, then, in each such case:

 

(a)              
any Warrant Price in effect immediately prior to the close of business on the record date fixed for the determination
of holders of shares of Common Stock entitled to receive the Distribution shall be reduced, effective as of the close of business
on such record date, to a price determined by multiplying such Warrant Price by a fraction of which (i) the numerator shall
be the Closing Bid Price of the shares of Common Stock on the Trading Day immediately preceding such record date minus the value
of the Distribution (as determined in good faith by the Company’s Board of Directors) applicable to one share of Common Stock,
and (ii) the denominator shall be the Closing Bid Price of the shares of Common Stock on the Trading Day immediately preceding
such record date; and

 

(b)              
the number of Shares shall be increased to a number of shares equal to the number of shares of Common Stock obtainable
immediately prior to the close of business on the record date fixed for the determination of holders of shares of Common Stock
entitled to receive the Distribution multiplied by the reciprocal of the fraction set forth in the immediately preceding paragraph
(a);

 

    	 	6	 

     

    

provided that in the event that the Distribution is of shares of
Common Stock(“Other Shares of Common Stock”) of a company whose common shares are traded on a national securities exchange
or a national automated quotation system, then the Holder may elect to receive a warrant to purchase Other Shares of Common Stock
in lieu of an increase in the number of Shares, the terms of which shall be identical to those of this Warrant, except that such
warrant shall be exercisable into the number of shares of Other Shares of Common Stock that would have been payable to the Holder
pursuant to the Distribution had the Holder exercised this Warrant immediately prior to such record date and with an aggregate
warrant price equal to the product of the amount by which the warrant price of this Warrant was decreased with respect to the Distribution
pursuant to the terms of the immediately preceding paragraph (a) and the number of Shares calculated in accordance with the first
part of this paragraph (b).

 

2.4.           
Other Adjustment Events. If any event occurs of the type contemplated by the provisions of this Article
2 but not expressly provided for by such provisions, then the Company’s Board of Directors will make an appropriate adjustment
in the Warrant Price and the number of Warrant Shares so as to protect the rights of the Holder; provided that no such adjustment
pursuant to this Article 2.4 will increase the Warrant Price or decrease the number of Shares as otherwise determined pursuant
to this Article 2.

 

2.5.           
No Impairment. Without the consent of the Holder, the Company shall not by amendment of its Certificate
of Incorporation or through a reorganization, transfer of assets, consolidation, merger, dissolution, issue, or sale of securities
or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms to be observed or performed
under this Warrant by the Company, but shall at all times in good faith assist in carrying out of all the provisions of this Article
2 and in taking all such action as may be necessary or appropriate to protect Holder’s rights under this Article against
impairment.

 

2.6.           
Fractional Shares. No fractional Shares shall be issuable upon exercise or conversion of this Warrant
and the number of Shares to be issued shall be rounded down to the nearest whole Share. If a fractional share interest arises upon
any exercise or conversion of the Warrant, the Company shall eliminate such fractional share interest by paying Holder in cash
equivalent to the amount computed by multiplying the fractional interest by the fair market value of a full Share.

 

2.7.           
Certificate as to Adjustments. Upon each adjustment of the Warrant Price and Shares, the Company shall
promptly notify Holder in writing, and, at the Company’s expense, promptly compute such adjustment, and furnish Holder with
a certificate of its Chief Financial Officer, Corporate Secretary or a senior financial officer setting forth such adjustment and
the facts upon which such adjustment is based. The Company shall, upon written request, furnish Holder a certificate setting forth
the Warrant Price and Shares in effect upon the date thereof and the series of adjustments leading to such Warrant Price and Shares.

 

ARTICLE
3 REPRESENTATIONS AND COVENANTS OF THE COMPANY. The Company represents
and warrants to the Holder as follows:

 

3.1.           
Representations and Warranties. The Company represents and warrants and covenants to the Holder as follows:
all Shares which may be issued upon the exercise of the

 

    	 	7	 

     

    

purchase right represented by this Warrant shall,
upon issuance, be duly authorized, validly issued, fully paid and nonassessable, and free of any liens and encumbrances except
for restrictions on transfer provided for herein or under applicable federal and state securities laws. The Company will at all
times reserve and keep available, out of its authorized but unissued share of Common Stock, solely for the purpose of providing
the exercise or conversion of this Warrant, the aggregate number of Shares issuable upon exercise or conversion of this Warrant.
The Company will use its reasonable best efforts to ensure that the Shares may be issued without violation of any law or regulation
applicable to the Company or of any requirement of any securities exchange applicable to the Company on which the Shares are listed
or traded.

 

3.2.           
No Stockholder Rights. Except as provided in this Warrant, and other than with regard to shares of the
Company’s common stock acquired by Holder other than pursuant to the exercise of this Warrant, the Holder will not have any
rights as a stockholder of the Company until the exercise of this Warrant.

 

3.3.           
Charges, Taxes and Expenses. Issuance of certificates for Shares to the Holder upon the exercise or conversion
of this Warrant shall be made without charge to the Holder for any issue or transfer tax or other incidental expense in respect
of the issuance of such certificates, all of which taxes and expenses shall be paid by the Company.

 

ARTICLE
4 REPRESENTATIONS, WARRANTIES OF THE HOLDER. The Holder represents
and warrants to the Company as follows:

 

4.1.           
Purchase for Own Account. This Warrant and the securities to be acquired upon exercise or conversion of
this Warrant by the Holder will be acquired for investment for the Holders account, not as a nominee or agent, and not with a view
to the public resale or distribution within the meaning of the Securities Act of 1933 (the “Securities Act”) and the
Holder has no present intention, and upon exercise or conversion will have no intention, of selling or engaging in any public distribution
of the same except pursuant to a registration or exemption. Holder also represents that the Holder has not been formed for the
specific purpose of acquiring this Warrant or the Shares.

 

4.2.           
Disclosure of Information. The Holder has received or has had full access to all the information it considers
necessary or appropriate to make an informed investment decision with respect to the acquisition of this Warrant and its underlying
securities. The Holder further has had an opportunity to ask questions and receive answers from the Company regarding the terms
and conditions of the offering of this Warrant and its underlying securities and to obtain additional information (to the extent
the Company possessed such information or could acquire it without unreasonable effort or expense) necessary to verify any information
furnished to the Holder or to which the Holder has access.

 

4.3.           
Investment Experience. The Holder understands that the purchase of this Warrant and its underlying securities
involves substantial risk. The Holder has experience as an investor in securities of companies in the development stage and acknowledges
that the Holder can bear the economic risk of such Holder’s investment in this Warrant and its underlying securities and
has such knowledge and experience in financial or business matters that the Holder is capable of evaluating the merits and risks
of its investment in this Warrant and its underlying securities

 

    	 	8	 

     

    

and/or has a preexisting personal or business
relationship with the Company and certain of its officers, directors or controlling persons of a nature and duration that enables
the Holder to be aware of the character, business acumen and financial circumstances of such persons.

 

4.4.           
Accredited Investor Status. The Holder is an “accredited investor” within the meaning of Regulation
D promulgated under the Securities Act.

 

4.5.           
The Securities Act. The Holder understands that this Warrant and the Shares issuable upon exercise or
conversion hereof have not been registered under the Securities Act in reliance upon a specific exemption therefrom, which exemption
depends upon, among other things, the bona fide nature of the Holder’s investment intent as expressed herein. The Holder
understands that this Warrant and the Shares issued upon any exercise or conversion hereof must be held indefinitely unless subsequently
registered under the Securities Act and qualified under applicable state securities laws, or unless exemption from such registration
and qualification are otherwise available. The Holder further understands that settlement of this Warrant is to be made in Shares
and, for the elimination of doubt, the fact that the Shares delivered on exercise of this Warrant will not be registered under
the Securities Act (as defined below) will not in any way require the Company to settle this Warrant otherwise than in Shares,
including without limitation, that there is no circumstance that would require the Company to settle this Warrant in cash.

 

ARTICLE
5 MISCELLANEOUS.

 

5.1.           
Term. Following the satisfaction of the Exercise Condition described in Article 1.1, this Warrant will
be exercisable in whole or in part at any time and from time to time on or before the Expiration Date.

 

5.2.           
Legends. This Warrant and the Shares shall be imprinted with a legend in substantially the following form:

 

NEITHER
THE ISSUANCE AND SALE OF THE SECURITIES REPRESENTED BY THIS CERTIFICATE NOR THE SECURITIES INTO WHICH THESE SECURITIES ARE EXERCISABLE
HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR APPLICABLE STATE SECURITIES LAWS. THE SECURITIES MAY NOT
BE OFFERED FOR SALE, SOLD, TRANSFERRED OR ASSIGNED (I) IN THE ABSENCE OF (A) AN EFFECTIVE REGISTRATION STATEMENT FOR THE SECURITIES
UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR (B) AN OPINION OF COUNSEL TO THE HOLDER (IF REQUESTED BY THE COMPANY), IN A FORM
REASONABLY ACCEPTABLE TO THE COMPANY, THAT REGISTRATION IS NOT REQUIRED UNDER SAID ACT OR (II) UNLESS SOLD OR ELIGIBLE TO BE SOLD
PURSUANT TO RULE 144 UNDER SAID ACT. NOTWITHSTANDING THE FOREGOING, THE SECURITIES MAY BE PLEDGED IN CONNECTION WITH A BONA FIDE
MARGIN ACCOUNT OR OTHER LOAN OR FINANCING ARRANGEMENT SECURED BY THE SECURITIES.

 

    	 	9	 

     

    

5.3.           
Compliance with Securities Laws on Transfer. This Warrant and the Shares issuable upon exercise of this
Warrant may not be transferred or assigned in whole or in part without compliance with applicable federal and state securities
laws by the transferor and the transferee (including, without limitation, the delivery of investment representation letters and
legal opinions reasonably satisfactory to the Company, as reasonably requested by the Company). The Company shall not require Holder
to provide an opinion of counsel if the transfer is to any affiliate of the Holder, provided that any such transferee is an “accredited
investor” as defined in Regulation D under the Securities Act; provided, however, in any such transfer the transferee shall
agree to be bound by the terms of this Warrant as if an original holder hereof.

 

5.4.           
Notices. All notices and other communications from the Company to the Holder, or vice versa, shall be
deemed delivered and effective when given personally or mailed by first-class registered or certified mail, postage prepaid (or
on the first business day after transmission by facsimile), at such address as may have been furnished to the Company or the Holder,
as the case may be, in writing by the Company or such Holder from time to time. Effective upon receipt of the fully executed Warrant,
all notices to the Holder shall be addressed as follows until the Company receives notice of a change of address in connection
with a transfer or otherwise:

 

[insert investor
notice information]

 

Notice to the Company shall be addressed as follows until the Holder receives notice
of a change in address:

 

Amyris, Inc.

5885 Hollis Street, Suite 100

Emeryville, CA 94608

Attn: General Counsel

Facsimile:

 

With a copy (which shall not constitute notice) to:

 

Fenwick & West LLP

801 California Street

Mountain View, CA 94041

Attn:

Facsimile:

 

5.5.           
Waiver. This Warrant and any term hereof may be changed, waived, discharged or terminated only by an instrument
in writing signed by the parties against which enforcement of such change, waiver, discharge or termination is sought.

 

5.6.           
Automatic Conversion upon Expiration. In the event that, upon the Expiration Date, the fair market value
of one Share as determined in accordance with Article 1.3 above is greater than the Warrant Price in effect on such date and the
Exercise Condition has occurred prior to such date, then this Warrant shall automatically be deemed on and as of such date to be
converted pursuant to Article 1.3 above as to all Shares (or such other securities) for which it

    	 	10	 

     

    

 

shall not previously have been exercised or converted,
and the Company shall promptly deliver a certificate representing the Shares (or such other securities) issued upon such conversion
to the Holder.

 

5.7.           
Counterparts. This Warrant may be executed in counterparts, all of which together shall constitute one
and the same agreement.

 

5.8.           
Amendment. This Warrant may be amended and the observance of any term of this Warrant may be waived only
with the written consent of the Company and the Holder.

 

5.9.           
Binding Effect. This Warrant shall be binding upon any successors or assigns of the Company.

 

5.10.       
Governing Law. This Warrant, and the provisions, rights, obligations, and conditions set forth herein,
and the legal relations between the parties hereto, including all disputes and claims, whether arising in contract, tort, or under
statute, shall be governed by and construed in accordance with the laws of the State of Delaware without giving effect to its conflict
of law provisions.

 

ARTICLE
6 CERTAIN DEFINITIONS.

 

“Bloomberg” means Bloomberg Financial
Markets.

 

“Closing Bid Price” and “Closing
Sale Price” means, for any security as of any date, the last closing bid price and last closing trade price, respectively,
for such security on the Principal Market, as reported by Bloomberg, or, if the Principal Market begins to operate on an extended
hours basis and does not designate the closing bid price or the closing trade price, as the case may be, then the last bid price
or last trade price, respectively, of such security prior to 4:00 p.m., New York time, as reported by Bloomberg, or, if the Principal
Market is not the principal securities exchange or trading market for such security, the last closing bid price or last trade price,
respectively, of such security on the principal securities exchange or trading market where such security is listed or traded as
reported by Bloomberg, or if the foregoing do not apply, the last closing bid price or last trade price, respectively, of such
security in the over-the-counter market on the electronic bulletin board for such security as reported by Bloomberg, or, if no
closing bid price or last trade price, respectively, is reported for such security by Bloomberg, the average of the bid prices,
or the ask prices, respectively, of any market makers for such security as reported in the “pink sheets” by OTC Markets
Group Inc. (formerly Pink Sheets LLC). If the Closing Bid Price or the Closing Sale Price cannot be calculated for a security on
a particular date on any of the foregoing bases, the Closing Bid Price or the Closing Sale Price, as the case may be, of such security
on such date shall be the fair market value as mutually determined by the Company and the Holder. If the Company and the Holder
are unable to agree upon the fair market value of such security, then such dispute shall be resolved pursuant to Section 5.11.
All such determinations to be appropriately adjusted for any stock dividend, stock split, stock combination or other similar transaction
during the applicable calculation period.

 

“Principal Market” means The NASDAQ
Stock Market.

 

    	 	11	 

     

    

“Trading Day” means any day on which
the Common Stock is traded on the Principal Market, or, if the Principal Market is not the principal trading market for the Common
Stock, then on the principal securities exchange or securities market on which the Common Stock is then traded; provided that “Trading
Day” shall not include any day on which the Common Stock is scheduled to trade on such exchange or market for less than 4.5
hours or any day that the Common Stock is suspended from trading during the final hour of trading on such exchange or market (or
if such exchange or market does not designate in advance the closing time of trading on such exchange or market, then during the
hour ending at 4:00 p.m., New York time).

 

 

[Balance of Page Intentionally Left Blank]

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

    	 	12	 

     

    

 

	 	“COMPANY”	 
	 	 	 	 
	 	Amyris, Inc.	 
	 	 	 	 
	 	 	 	 
	 	By: 	 	 
	 	 	John Melo, Chief Executive Officer

 

 

 

	AGREED AND ACKNOWLEDGED:
	“HOLDER” 	 
	 	 
	[insert investor name]

 

	 	 
	 	 
	(Signature)	 
	 	 
	(Print Name)	 
	 	 
	(Title)	 

 

 

     

     

    

Exhibit A

 

EXERCISE NOTICE

 

TO BE EXECUTED BY THE
REGISTERED HOLDER TO EXERCISE THIS

WARRANT TO PURCHASE STOCK

 

AMYRIS,
INC.

 

The undersigned holder hereby exercises the
right to purchase _________________ of the shares of Common Stock (“Shares”) of Amyris, Inc. a Delaware corporation
(the “Company”), evidenced by Warrant to Purchase Stock No. _______ (the “Warrant”).
Capitalized terms used herein and not otherwise defined shall have the respective meanings set forth in the Warrant.

 

1.     Form of Exercise Price. The Holder
intends that payment of the Aggregate Exercise Price shall be made as:

 

		____________	a “Cash Exercise” with respect to _________________ Shares; and/or

 

		____________	a “Cashless Exercise” with respect to _______________ Shares.

 

2.     Payment of Exercise Price. In the
event that the Holder has elected a Cash Exercise with respect to some or all of the Shares to be issued pursuant hereto, the Holder
shall pay the Aggregate Exercise Price in the sum of $___________________ to the Company in accordance with the terms of the Warrant.

 

3.      Delivery of Shares. The Company
shall deliver to Holder, or its designee or agent as specified below, __________ Shares in accordance with the terms of the Warrant.
Delivery shall be made to Holder, or for its benefit, as follows:

 

☐    Check
here if requesting delivery as a certificate to the following name and to the following address:

 

	Issue to:	 
	 	 
	 	 

 

☐    Check
here if requesting delivery by Deposit/Withdrawal at Custodian as follows:

 

	DTC Participant:	 
	DTC Number:	 
	Account Number:	 
	 	 
	 	 	 

     

     

    

 

	
        Date: _____________ __, _____

         

        _____________________________

        Name of Registered Holder

         

         

	
        By: ______________________

        Name:

        Title:

        

        

         

        Tax ID:____________________________

         

        Facsimile:__________________________

         

        E-mail Address:_____________________

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