Document:

Exhibit 10.24  

 ANACOR PHARMACEUTICALS, INC.  

CHANGE OF CONTROL AND SEVERANCE AGREEMENT  

        This Change of Control and Severance Agreement (the "Agreement") is dated as of
August 21, 2007, by and between Christine Gray-Smith ("Employee") and Anacor Pharmaceuticals, Inc., a Delaware corporation
(the "Company" or "Anacor"). This Agreement is intended to provide Employee with certain benefits
described herein upon the occurrence of specific events. 

RECITALS 

        A.    It
is expected that another company may from time to time consider the possibility of acquiring the Company or that a change in control may otherwise occur, with or
without the approval of the Company's Board of Directors. The Board of Directors recognizes that such consideration can be a distraction to Employee and can cause Employee to consider alternative
employment opportunities. The Board of Directors has determined that it is in the best interests of the Company and its stockholders to assure that the Company will have the continued dedication and
objectivity of the Employee, notwithstanding the possibility, threat or occurrence of a Change of Control (as defined below) of the Company. 

        B.    The
Company's Board of Directors believes it is in the best interests of the Company and its stockholders to retain Employee and provide incentives to Employee to
continue in the service of the Company. 

        C.    The
Board of Directors further believes that it is imperative to provide Employee with certain benefits upon termination of Employee's employment, in connection with a
Change of Control and otherwise, which benefits are intended to provide Employee with financial security and provide sufficient income and encouragement to Employee to remain with the Company,
notwithstanding the possibility of a Change of Control. 

        D.    To
accomplish the foregoing objectives, the Board of Directors has directed the Company, upon execution of this Agreement by Employee, to agree to the terms provided in
this Agreement. 

        Now
therefore, in consideration of the mutual promises, covenants and agreements contained herein, and in consideration of the continuing employment of Employee by the Company, the
parties hereto agree as follows: 

        1.    At-Will Employment.    The Company and Employee acknowledge that Employee's
employment is and shall continue to be at-will, as defined under applicable law, and that Employee's employment with the Company may be terminated by either party at any time for any or no
reason. If Employee's employment terminates for any reason, Employee shall not be entitled to any payments, benefits, award or compensation other than as provided in this Agreement. The terms of this
Agreement shall terminate upon the earlier of (i) the date on which Employee ceases to be employed as an officer of the Company, other than as a result of an involuntary termination by the
Company without Cause (as defined below) or Employee's resignation for Good Reason (as defined below) following a Change of Control; or (ii) the date that all obligations of the parties
hereunder have been satisfied. A termination of the terms of this Agreement pursuant to the preceding sentence shall be effective for all purposes, except that such termination shall not affect the
payment or provision of compensation or benefits on account of a termination of employment occurring prior to the termination of the terms of this Agreement. The rights and duties created by this
Section 1 may not be modified in any way except by a written agreement executed by an officer of the Company upon direction from the Board of Directors. 

        2.    Benefits Upon Termination of Employment.    

        (a)    Termination In Connection with or Following a Change of Control.    In the event that
Employee's employment is terminated as a result of an involuntary termination other than for Cause or if Employee resigns for Good Reason at any time within ninety (90) days prior to and 

 

twelve
(12) months following the effective date of a Change of Control, then Employee will be entitled to receive severance benefits as follows: (i) a severance payment equal to twelve
(12) months of the base salary which Employee was receiving immediately prior to the Change of Control, paid in a lump sum within thirty (30) days of the effective date of the Release,
defined in Section 5(c) below (the "Release Effective Date"), (ii) continuation of the health insurance benefits provided to Employee for
Employee and her eligible dependents immediately prior to the Change of Control at Company expense pursuant to the terms of the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended
("COBRA") or other applicable law through the earlier of twelve (12) months following Employee's termination date or the date upon which Employee
is no longer eligible for such COBRA or other benefits under applicable law, and (iii) each stock option to purchase the Company's Common Stock and all shares of restricted stock granted to
Employee over the course of her employment with the Company and held by Employee on the date of termination of employment shall become immediately vested as to 100% of the then unvested options and
shares. In addition, Employee will receive payment(s) for all accrued and unpaid salary, bonuses and PTO as of the date of Employee's termination of employment. 

        (b)    Termination Not In Connection with or Following a Change of Control.    In the event
that Employee's employment is terminated as a result of an involuntary termination other than for Cause or if Employee resigns for Good Reason at any time more than ninety (90) days prior to or
more than twelve (12) months following the effective date of a Change of Control (an "Individual Termination"),  and such termination occurs after
completion of an underwritten public offering by the Company of shares of its Common Stock under the Securities Act of
1933, as amended (an "IPO"), then Employee will be entitled to receive severance benefits as follows: (i) a severance payment equal to nine
(9) months of the base salary which Employee was receiving immediately prior to the termination date, paid in a lump sum within thirty (30) days of the Release Effective Date, and
(ii) continuation of the health insurance benefits provided to Employee and her eligible dependents immediately prior to the termination date at Company expense pursuant to COBRA or other
applicable law through the earlier of nine (9) months following Employee's termination date or the date upon which Employee is no longer eligible for such COBRA or other benefits under
applicable law. In the event that an Individual Termination occurs prior to an IPO, Employee will be entitled to receive severance benefits as follows: (x) a severance payment equal to six
(6) months of the base salary which Employee was receiving immediately prior to the termination date, paid in a lump sum within thirty (30) days of the Release Effective Date, and
(y) continuation of the health insurance benefits provided to Employee and her eligible dependents immediately prior to the Change of Control at Company expense (either directly or through
reimbursement of Employee, at Employee's discretion) pursuant to COBRA or other applicable law through the earlier of six (6) months following Employee's termination date or the date
upon which Employee is no longer eligible for such COBRA or other benefits under applicable law. Further, in the event that an Individual Termination occurs at any time prior to the first anniversary
of Employee's Start Date with the Company (as such term is defined in Employee's Offer Letter from the Company dated June 18, 2007, the "Offer Letter"), the cliff vesting date applicable to the
stock option granted to Employee in connection with the commencement of Employee's employment with the Company shall be waived and Employee will receive vesting credit on the termination date equal to
1/48 of the option shares for each full month of her employment from the Start Date. In addition, Employee will receive payment(s) for all accrued and unpaid salary, bonuses and PTO as of the date of
Employee's termination of employment. 

        (c)    Termination for Cause or Voluntary Resignation other than for Good Reason.    If
Employee's employment is terminated for Cause at any time or if Employee voluntarily resigns from the Company at any time for any reason other than Good Reason, then Employee shall not be entitled to
receive payment of any severance benefits under this Agreement. Employee will receive 

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payment(s)
for all accrued and unpaid salary and PTO as of the date of Employee's termination of employment and Employee's benefits will be continued under the Company's then existing benefit plans
and policies in accordance with such plans and policies in effect on the date of termination and in accordance with applicable law. 

        3.    Definition of Terms.    The following terms referred to in this Agreement shall have the
following meanings: 

        (a)    Change of Control.    "Change of
Control" shall mean a sale of all or substantially all of the Company's assets, or any merger or consolidation of the Company with or into another corporation other than a
merger or consolidation in which the holders of more than 50% of the shares of capital stock of the Company outstanding immediately prior to such transaction continue to hold (either by voting
securities remaining outstanding or by their being converted into voting securities of the surviving entity) more than 50% of the total voting power represented by the voting securities of the
Company, or such surviving entity, outstanding immediately after such transaction. For purposes of clarification, neither an equity financing occurring prior to an IPO nor an IPO will be a Change of
Control, even if equity securities representing greater than 50% of the total voting power of the Company are sold in the transaction. 

        (b)    Cause.    "Cause" shall mean, as
determined by the Board acting in good faith and based on information then known to it: (A) gross negligence or willful misconduct in the performance of duties to the Company where such gross
negligence or willful misconduct has resulted or is likely to result in substantial and material damage to the Company or its subsidiaries; (B) a material failure to comply with the Company's
written policies after having received from the Company notice of, and a reasonable time to cure, such failure; (C) repeated unexplained or unjustified absence from the Company;
(D) conviction of a felony or a crime involving moral turpitude causing material harm to the standing and reputation of the Company; (E) unauthorized use or disclosure of any proprietary
information or trade secrets of the Company or any other party to whom Employee owes an obligation of non-disclosure as a result of Employee's relationship with the Company, which use or
disclosure causes or is likely to cause material harm to the Company; or (F) Employee's death or Permanent Disability. 

        (c)    Good Reason.    "Good Reason" for
Employee's resignation of her employment will exist following the occurrence of any of the following without Employee's consent: (A) a material reduction or change in job duties,
responsibilities or authority inconsistent with Employee's position with the Company and Employee's prior duties, responsibilities or authority; (B) a reduction of Employee's then current base
salary by more than 10 percent (10%); or (C) a relocation of the principal place for performance of Employee's duties to the Company to a location more than twenty-five
(25) miles from the Company's then current location; provided that Employee gives written notice to the Company of the event forming the basis of the Good Reason resignation within sixty
(60) days of the date the Company gives written notice to Employee of its affirmative decision to take an action set forth in (A), (B) or (C) above, the Company fails to cure such
basis for the Good Reason resignation within thirty (30) days after receipt of Employee's written notice and Employee terminates employment within one hundred twenty (120) days following
the date on which Employee received notice from the Company of the event forming the basis for the Good Reason resignation. 

        (d)    Permanent Disability.    "Permanent
Disability" shall mean Employee's inability to engage in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be
expected to result in death or which has lasted or can be expected to last for a continuous period of not less than six (6) months. 

        4.    Parachute Payments.    In the event that the acceleration and severance benefits
provided for in this Agreement (A) constitute "parachute payments" within the meaning of Section 280G of the 

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Internal
Revenue Code of 1986, as amended (the "Code") and (B) but for this paragraph, would be subject to the excise tax imposed by
Section 4999 of the Code, then Employee's benefits hereunder shall be payable either: (X) in full, or (Y) as to such lesser amount which would result in no portion of such
severance benefits being subject to excise tax under Section 4999 of the Code, whichever of the foregoing amounts, taking into account the applicable federal, state and local income taxes and
the excise tax imposed by Section 4999, results in the receipt by Employee on an after-tax basis, of the greatest amount of benefits hereunder, notwithstanding that all or some
portion of such benefits may be taxable under Section 4999 of the Code. Unless the Company and Employee otherwise agree in writing, any determination required under this paragraph shall be made
in writing by the public accountants designated by the Company (the "Accountants"), whose determination shall be conclusive and binding upon Employee
and the Company for all purposes. For purposes of making the calculations required by this paragraph, the Accountants may make reasonable assumptions and approximations concerning applicable taxes and
may rely on reasonable, good faith interpretations concerning the application of Section 280G and 4999 of the Code. The Company and Employee shall furnish to the Accountants such information
and documents as the Accountants may reasonably request in order to make a determination under this paragraph. The Company shall bear all costs the Accountants may reasonably incur in connection with
any calculations contemplated by this paragraph. 

        5.    Limitations and Conditions on Benefits    

        (a)    Income and Employment Taxes.    Employees agrees that she shall be responsible for any
applicable taxes of any nature (including any penalties or interest that may apply to such taxes) that the Company reasonably determines apply to any payment made hereunder, that her receipt of any
benefit hereunder is conditioned on her satisfaction of any applicable withholding or similar obligations that apply to such benefit, and that any cash payment owed hereunder will be reduced to
satisfy any such withholding or similar obligations that may apply. 

        (b)    Code Section 409A.    Notwithstanding any provision of this Agreement to the
contrary, if, at the time of Employee's termination of employment with the Company, Employee is a "specified employee" (as defined in Section 409A of the Code) and the deferral of the
commencement of any severance payments or benefits otherwise payable pursuant to this Agreement as a result of such termination of employment is necessary in order to prevent any accelerated or
additional tax under Section 409A of the Code, then the Company will defer the commencement of the payment of any such severance payments or benefits hereunder (without any reduction in such
payments or benefits ultimately paid or provided to Employee) that will not and could not under any circumstances, regardless of when such termination occurs, be paid in full by March 15 of the
year following Employee's termination and are in excess of the lesser of (i) two (2) times Employee's then annual compensation or (ii) two (2) times the limit on
compensation then set forth in Section 401(a)(17) of the Code and will not be paid by the end of the second calendar year following the year in which the termination occurs, until the first
payroll date that occurs after the date that is six (6) months following Employee's "separation of service" with the Company (as defined under Code Section 409A). If any payments are
deferred due to such requirements, such amounts will be paid in a lump sum to Employee on the earliest of (a) Employee's death following the date of Employee's termination of employment with
the Company or (ii) the first payroll date that occurs after the date that is six (6) months following Employee's "separation of service" with the Company. For these purposes, each
severance payment or benefit is hereby designated as a separate payment or benefit and will not collectively be treated as a single payment or benefit. This paragraph is intended to comply with the
requirements of Section 409A of the Code so that none of the severance payments and benefits to be provided hereunder will be subject to the additional tax imposed under Section 409A of
the Code and any ambiguities herein will be interpreted to so comply. Employee and the Company agree to work together in good faith to consider amendments to this Agreement and to take such reasonable
actions which are necessary, 

4

 

appropriate
or desirable to avoid imposition of any additional tax or income recognition prior to actual payment to Employee under Section 409A of the Code. 

        (c)    Release Prior to Receipt of Benefits.    Prior to the receipt of any benefits under
this Agreement, Employee shall execute a release of claims agreement (the "Release") in the form provided by the Company. Such Release shall specifically relate to all of Employee's rights and claims
in existence at the time of such execution and shall confirm Employee's obligations under the Company's standard
form of proprietary information agreement. The Company shall use reasonable efforts to provide the form Release to Employee within fifteen (15) days of Employee's termination date. 

        6.    Conflicts.    Employee represents that her performance of all the terms of this
Agreement will not breach any other agreement to which Employee is a party. Employee has not, and will not during the term of this Agreement, enter into any oral or written agreement in conflict with
any of the provisions of this Agreement. Employee further represents that she is entering into or has entered into an employment relationship with the Company of her own free will and that she has not
been solicited as an employee in any way by the Company. 

        7.    Successors.    Any successor to the Company (whether direct or indirect and whether by
purchase, lease, merger, consolidation, liquidation or otherwise) to all or substantially all of the Company's business and/or assets shall assume the obligations under this Agreement and agree
expressly to perform the obligations under this Agreement in the same manner and to the same extent as the Company would be required to perform such obligations in the absence of a succession. The
terms of this Agreement and all of Employee's rights hereunder and thereunder shall inure to the benefit of, and be enforceable by, Employee's personal or legal representatives, executors,
administrators, successors, heirs, distributees, devisees and legatees. 

        8.    Notice.    Notices and all other communications contemplated by this Agreement shall be
in writing and shall be deemed to have been duly given when personally delivered or when mailed by U.S. registered or certified mail, return receipt requested and postage prepaid. Mailed notices to
Employee shall be addressed to Employee at the home address which Employee most recently communicated to the Company in writing. In the case of the Company, mailed notices shall be addressed to its
corporate headquarters, and all notices shall be directed to the attention of its Secretary. 

        9.    Miscellaneous Provisions.    

        (a)    No Duty to Mitigate.    Employee shall not be required to mitigate the amount of any
payment contemplated by this Agreement (whether by seeking new employment or in any other manner), nor shall any such payment be reduced by any earnings that Employee may receive from any other
source. 

        (b)    Waiver.    No provision of this Agreement shall be modified, waived or discharged
unless the modification, waiver or discharge is agreed to in writing and signed by Employee and by an authorized officer of the Company (other than Employee). No waiver by either party of any breach
of, or of compliance with, any condition or provision of this Agreement by the other party shall be considered a waiver of any other condition or provision or of the same condition or provision at
another time. 

        (c)    Whole Agreement.    No agreements, representations or understandings (whether oral or
written and whether express or implied) which are not expressly set forth in this Agreement have been made or entered into by either party with respect to the subject matter hereof. Unless otherwise
specified herein, this Agreement supersedes any agreement (or portion thereof) concerning similar subject matter dated prior to the date of this Agreement (including but not limited to
Sections 7 and 8 of the Offer Letter and Exhibit A attached thereto), and by execution 

5

 

of
this Agreement both parties agree that any such predecessor agreement shall be deemed null and void. 

        (d)    Choice of Law.    The validity, interpretation, construction and performance of this
Agreement shall be governed by the laws of the State of California without reference to conflict of laws provisions. 

        (e)    Severability.    If any term or provision of this Agreement or the application thereof
to any circumstance shall, in any jurisdiction and to any extent, be invalid or unenforceable, such term or provision shall be ineffective as to such jurisdiction to the extent of such invalidity or
unenforceability without invalidating or rendering unenforceable the remaining terms and provisions of this Agreement or the application of such terms and provisions to circumstances other than those
as to which it is held invalid or unenforceable, and a suitable and equitable term or provision shall be substituted therefor to carry out, insofar as may be valid and enforceable, the intent and
purpose of the invalid or unenforceable term or provision. 

        (f)    Arbitration.    Employee and the Company agree to attempt to settle any disputes
arising in connection with this Agreement through good faith consultation. In the event that Employee and the Company are not able to resolve any such disputes within fifteen (15) days after
notification in writing to the other, Employee and the Company agree that any dispute or claim arising out of or in connection with this Agreement will be finally settled by binding arbitration in
Santa Clara County, California in accordance with the rules of the American Arbitration Association by one arbitrator mutually agreed upon by the parties. The arbitrator will apply California law,
without reference to rules of conflicts of law or rules of statutory arbitration, to the resolution of any dispute. Except as set forth in Subparagraph (e) above, the arbitrator shall not have
authority to modify the terms of this Agreement. The Company shall pay the costs of the arbitration proceeding. Each party shall, unless otherwise determined by the arbitrator, bear its or her own
attorneys' fees and expenses, provided however that if Employee prevails in an arbitration proceeding, the Company shall reimburse Employee for her reasonable attorneys' fees and costs. Judgment on
the award rendered by the arbitrator may be entered in any court having jurisdiction thereof. Notwithstanding the foregoing, the Company and Employee may apply to any court of competent jurisdiction
for preliminary or interim equitable relief, or to compel arbitration in accordance with this paragraph, without breach of this arbitration provision. 

        (g)    Legal Fees and Expenses.    The parties shall each bear their own expenses, legal fees
and other fees incurred in connection with the execution of this Agreement. 

        (h)    No Assignment of Benefits.    The rights of any person to payments or benefits under
this Agreement shall not be made subject to option or assignment, either by voluntary or involuntary assignment or by operation of law, including (without limitation) bankruptcy, garnishment,
attachment or other creditor's process, and any action in violation of this Section 9(h) shall be void. 

        (i)    Assignment by Company.    The Company may assign its rights under this Agreement to an
affiliate, and an affiliate may assign its rights under this Agreement to another affiliate of the Company or to the Company. In the case of any such assignment, the term "Company" when used in a
section of this Agreement shall mean the corporation that actually employs the Employee. 

        (j)    Counterparts.    This Agreement may be executed in counterparts, each of which shall be
deemed an original, but all of which together will constitute one and the same instrument. 

6

 

        The
parties have executed this Agreement on the date first written above. 

 

 

					
	 	 	ANACOR PHARMACEUTICALS, INC.
	

 	
 	
 By:	
 	
 /s/ DAVID P. PERRY

  David P. Perry
	

 	
 	
 Title:	
 	
 Chief Executive Officer
	

 	
 	
 Address:	
 	
 1060 East Meadow Circle

Palo Alto, CA 94303-4230
	

 	
 	
 CHRISTINE GRAY-SMITH
	

 	
 	
 Signature:	
 	
 /s/ CHRISTINE GRAY-SMITH

 
	

 	
 	
 Address:	
 	

 

 

 7

 

 

  

 AMENDMENT TO CHANGE OF CONTROL AND SEVERANCE AGREEMENT  

        This Amendment to Change of Control and Severance Agreement ("Amendment") is entered
into as of December 30, 2008 (the "Effective Date"), by and between Anacor Pharmaceuticals, Inc., a Delaware corporation (the "Company")
and Christine Gray-Smith ("Employee"). 

 RECITALS  

        WHEREAS, the Company and Employee have entered into that certain Change of Control and Severance Agreement dated as of
August 21, 2007, attached hereto as Exhibit A (the "Change of Control Agreement"), which
provides for benefits upon the occurrence of certain terminations of Employee's employment; and 

        WHEREAS,
the parties desire to amend certain provisions of the Change of Control Agreement to ensure full documentary compliance with applicable provisions of Section 409A
("Code Section 409A") of
the Internal Revenue Code of 1986, as amended, and the final regulations issued thereunder, pursuant to the terms and conditions set forth below. 

 AGREEMENT  

        NOW, THEREFORE, in consideration of the foregoing and the mutual agreements contained herein, the Company and Employee agree to amend
the Change of Control Agreement effective as of the Effective Date as follows. Except as otherwise defined herein, capitalized terms shall have the meanings assigned to them in the Change of Control
Agreement. 

        1.     The
following shall be added at the end of Section 4: 

        "In
the event that a reduction in payments and/or benefits is required under this section 4, such reduction shall occur in the following order: (1) reduction of cash
payments; (2) reduction of acceleration of vesting of options and shares; and (3) reduction of other benefits paid to Employee. If the acceleration of vesting of options and shares is to
be reduced, such acceleration of vesting shall be cancelled in the reverse order of the highest price option grant or highest purchase price per share down to the lowest priced option grant or lowest
purchase price per share." 

        2.     The
following shall be added at the beginning of Section 5(b): 

        "All
payments to be made upon a termination of employment under this Agreement may be made only upon a "separation of service" within the meaning of Section 409A of the Code and
the Department of Treasury regulations and other guidance promulgated thereunder (a "Separation from Service"." 

        3.     Section 5(c)
shall be amended in its entirety to read as follows: 

        "As
a condition of receiving the benefits under this Agreement, Employee shall execute, and allow to become effective, a release of claims agreement (the
"Release") not later than fifty (50) days following Employee's Separation from Service in the form provided by the Company. Such Release shall
specifically relate to all of Employee's rights and claims in existence at the time of such execution and shall confirm Employee's obligations under the Company's standard form of proprietary
information agreement. Unless the Release is timely executed by Employee, delivered to the Company, and becomes effective within the required period (the date on which the Release becomes effective,
the 

1

 

"Release Date"), Employee will not receive any of the benefits provided for under this Agreement. In no event will benefits be provided to Employee
until the Release becomes effective. Any lump sum payment owed to Employee shall be paid within ten (10) business days following the Release Date, but in no event later than March 15 of
the year following the year in which the applicable event occurs." 

        4.     Except
as expressly set forth herein, the Change of Control Agreement shall remain in full force and effect and shall not be modified or altered in any other way pursuant
to this Amendment. 

        5.     Each
of the Company and Employee acknowledges and represents that, in executing this Amendment, such party has had the opportunity to seek advice as to its legal rights
from legal counsel and such party has read and understood all of the terms and provisions of this Amendment. This Amendment shall not be construed against any party by reason of the drafting or
preparation thereof. 

        6.     This
Amendment may be executed in two or more counterparts, each of which shall be deemed an original and all of which together shall constitute one instrument. This
Amendment shall be governed by the laws of the State of California. 

        IN
WITNESS WHEREOF, the parties have caused this Amendment to be executed by their duly authorized representatives. 

 

 

							
	ANACOR PHARMACEUTICALS, INC.	 	 	 	 
	
 By:	
 	
/s/ DAVID P. PERRY	
 	
By:	
 	
/s/ CHRISTINE GRAY-SMITH
	 	 	

  David P. Perry	 	 	 	

  Christine Gray-Smith
	
 Title:	
 	
Chief Executive Officer

	
 	

 	
 	

 

 

 2

 

Amendment
to Change of Control and Severance Agreement

Christine Gray-Smith 

EXHIBIT A

 CHANGE OF CONTROL AND SEVERANCE AGREEMENT (Attached)  

3Exhibit 10.25  

 LEASE  

 BETWEEN  

 HDP ASSOCIATES, LLC, LESSOR  

 AND  

 ANAMAX, INC., LESSEE  

 1060 East Meadow Circle

Palo Alto, California  

 October 16, 2002  

 

 TABLE OF CONTENTS 

 

 

							
	Paragraph

 
	 	 
	 	Page 	 
	1.	 	Lease	 	 	1	 
	2.	 	Term	 	 	1	 
	3.	 	Monthly Base Rent	 	 	1	 
	4.	 	Additional Rent; Operating Expenses and Taxes	 	 	2	 
	5.	 	Payment of Rent	 	 	5	 
	6.	 	Letter of Credit	 	 	5	 
	7.	 	Use	 	 	6	 
	8.	 	Environmental Matters	 	 	6	 
	9.	 	Taxes on Lessee's Property	 	 	8	 
	10.	 	Insurance	 	 	8	 
	11.	 	Indemnification	 	 	9	 
	12.	 	Condition of the Premises	 	 	10	 
	13.	 	Maintenance and Repairs; Alterations; Surrender and Restoration	 	 	11	 
	14.	 	Utilities and Services.	 	 	13	 
	15.	 	Liens	 	 	13	 
	16.	 	Assignment and Subletting	 	 	13	 
	17.	 	Waiver	 	 	16	 
	18.	 	Holding Over	 	 	16	 
	19.	 	Damage or Destruction	 	 	16	 
	20.	 	Eminent Domain	 	 	18	 
	21.	 	Remedies	 	 	18	 
	22.	 	Lessee's Personal Property	 	 	19	 
	23.	 	Notices	 	 	19	 
	24.	 	Estoppel Certificates	 	 	20	 
	25.	 	Signage	 	 	20	 
	26.	 	Real Estate Brokers	 	 	21	 
	27.	 	Subordination; Attornment	 	 	21	 
	28.	 	Breach by Lessor	 	 	21	 
	29.	 	Approvals	 	 	21	 
	30.	 	Lessor's Entry	 	 	21	 
	31.	 	Attorneys' Fees	 	 	22	 
	32.	 	Compliance with CC&Rs	 	 	22	 
	33.	 	Quiet Possession	 	 	22	 
	34.	 	General Provisions	 	 	22	 

 

 i

 L E A S E  

1060 East Meadow Circle

Palo Alto, California 

        THIS
LEASE, referred to herein as "this Lease," dated for reference purposes as of October 16, 2002, is made and entered into by and between HDP ASSOCIATES, LLC, a California
limited liability company ("Lessor"), and ANAMAX, INC., a Delaware corporation ("Lessee"). 

        RECITALS:

        A.    Lessor
is the owner of the real property commonly known by the street address of 1060 East Meadow Circle, Palo Alto, California 94303, more particularly described on
Exhibit "A" attached hereto and incorporated by reference herein, consisting of a parcel of land, together with all easements and appurtenances thereto (the "Land"), and the existing single story
building thereon containing approximately 15,300 rentable square feet (the "Building"), and all other improvements located thereon (collectively, the "Improvements"). The Land and Improvements are
referred to herein collectively as the "Premises." 

        B.    Lessor
and Lessee wish to enter into this Lease of the Premises upon the terms and conditions set forth herein. 

        NOW,
THEREFORE, the parties agree as follows: 

        1.    Lease.    Lessor hereby leases to Lessee, and Lessee hereby leases from Lessor the Premises at the rental and
upon all of the terms and conditions set forth herein. 

        2.    Term.    

        (a)   The
term of this Lease (the "term") shall commence on November 1, 2002 (the "Commencement Date"), and shall expire on October 31, 2005 (the "Expiration
Date"), unless sooner terminated in accordance with the provisions hereof. On or after the Commencement Date Lessor and Lessee shall confirm in writing the Commencement Date and the Expiration Date of
the term by executing and delivering the Commencement Memorandum in the form attached hereto as Exhibit "B" and incorporated by reference herein. 

        (b)   Lessee
shall be allowed access into the Premises prior to the Commencement Date for installation of furniture, fixtures, phone and cabling and other Lessee improvements.
Such early entry shall be subject to all the terms and provisions of this Lease, except that Lessee's obligation to pay Base Rent, Additional Rent or other charges shall not commence until the
Commencement Date, and Lessee's access to and use of the Premises prior to the Commencement Date shall not be deemed delivery of possession of the Premises to Lessee. Prior to Lessee's early entry of
the Premises, Lessee shall deliver to Lessor written evidence that Lessee's commercial general liability insurance coverage is in effect in accordance with Paragraph 10(a) hereof. 

        3.    Monthly Base Rent.    

        (a)   Lessee
shall pay to Lessor during the term of this Lease Monthly Base Rent as follows: 

 

 

								
	 
	 	Period Rent/SF/Mo./NNN 	 	Amount 	 
	 November 1, 2002—October 31, 2003
	 	$	1.75	 	$	26,775	 
	 November 1, 2003—October 31, 2004
	 	$	1.80	 	$	27,540	 
	 November 1, 2004—October 31, 2005
	 	$	1.85	 	$	28,305	 

 

 Monthly
Base Rent shall be payable on a NNN basis and shall be payable by Lessee to Lessor in accordance with Paragraph 5 hereof. Concurrently with the execution and delivery of this Lease by
Lessor and Lessee, Lessee shall pay to Lessor (1) the sum of Twenty-six Thousand Seven Hundred Seventy-five Dollars ($26,775) representing the Monthly Base Rent for the
month of November 2002, and (2) an amount equal to the estimated Operating Expenses and Taxes for the month of November 2002. 

 

        (b)   Notwithstanding
the foregoing, if Lessor has not completed the work to be performed by Lessor pursuant to Paragraph 12(a) and Paragraph 12(b) for which
building permits are required ("permitted work"), or if Lessor otherwise is unable to deliver possession of the Premises to Lessee within fifteen (15) days after the execution and delivery of
this Lease and the receipt by Lessor of the November 2002 Monthly Base Rent, estimated Operating Expenses and Taxes for November 2002 (provided that Lessor has received the Letter of
Credit prior to the expiration of said period of fifteen (15) days), Lessee shall receive 1 day of free rent from and after the expiration of said period of fifteen (15) days for
each day of delay in delivery of possession or delay in completion of Lessor's permitted work. 

        4.    Additional Rent; Operating Expenses and Taxes.    

        (a)   In
addition to the Monthly Base Rent payable by Lessee pursuant to Paragraph 3, Lessee shall pay to Lessor as "Additional Rent" the Operating Expenses of the
Premises in accordance with Paragraph 4(b) hereof and real property taxes and assessments levied or assessed against the Premises in accordance with Paragraph 4(c) hereof. Monthly Base
Rent and Additional Rent are referred to herein collectively as "rent" or "rental." 

        (b)   "Operating
Expenses," as used herein, shall include all direct costs of management, operation, maintenance, repair and replacement of the Premises as determined by
generally accepted accounting principles (unless excluded by this Lease), including, but not limited to: 

        Personal
property taxes related to the Premises; any parking taxes or parking levies imposed on the Premises in the future by any governmental agency; a management fee in an amount equal
to three percent (3%) of the Monthly Base Rent in effect from time to time which management fee shall be payable to Lessor, any affiliate of Lessor, or an independent property manager selected by
Lessor; water and sewer charges; waste disposal; insurance premiums for insurance coverages maintained by Lessor pursuant to Paragraph 10(b) hereof; license, permit, and inspection fees;
charges for electricity, heating, air conditioning, gas, and any other utilities (including, without limitation, any temporary or permanent utility surcharge or other exaction); maintenance and repair
of the roof membrane; maintenance and replacement of floor and window coverings; repair and maintenance of the heating, ventilating, air conditioning, mechanical and electrical systems, plumbing and
sewage systems; landscaping, gardening, and tree trimming; glazing; repair, maintenance, cleaning, sweeping, and striping of the parking area; exterior Building lighting and parking lot lighting;
supplies, materials, equipment and tools used in the maintenance of the Premises; except as provided herein, the cost of any capital expenditures for any improvements or changes to the Building,
Improvements, or existing Building equipment or facilities (i.e., HVAC components, replacement of roof membrane, or parking lot improvements) which are
typically treated as capital expenditures for accounting purposes, provided that Lessor shall amortize said expenditures over the useful life of said items (together with interest on the unamortized
balance at the rate equal to the effective rate of interest on Lessor's bank line of credit at the time of completion of said improvements, but in no event in excess of twelve percent (12%) per annum)
as an Operating Expense in accordance with generally accepted accounting principles and only the monthly amortized cost of said items shall be included in the monthly Operating Expenses. Operating
Expenses shall also include any other expense or charge, whether or not described herein not specifically excluded by other provisions of this Lease, which in accordance with generally accepted
accounting principles would be considered an expense of managing, operating, maintaining, and repairing the Premises. Costs for accounting services incurred in the calculation of Operating Expenses
and Taxes as defined herein shall be recouped through the management fee and shall not be included in Operating Expenses. 

        (c)   Real
property taxes and assessments upon the Premises, during each lease year or partial lease year during the term of this Lease are referred to herein as "Taxes." 

        As
used herein, "Taxes" shall mean all taxes, assessments, levies, and other charges of any kind or nature whatsoever, general and special, foreseen and unforeseen (including all
installments of principal 

2

 

and
interest required to pay for any general or special assessments for public improvements, services, or benefits), and any increase in Taxes resulting from a reassessment due to alterations or
improvements to the Premises provided for herein, or due to any other alterations or improvements performed at any time during the term of this Lease, now or hereafter imposed by any governmental or
quasi-governmental authority or special district having the direct or indirect power to tax or levy assessments, which are levied or assessed against or with respect to (1) the value,
occupancy, or use of the Premises (as now constructed or as may at any time hereinafter be constructed, altered, or otherwise changed); (2) the fixtures, equipment, and other real or personal
property of Lessor that are an integral part of the Premises; (3) the use of the areas of the Premises located outside of the Building, public utilities, or energy within the Premises;
(4) all charges, levies, or fees imposed by reason of environmental regulation or other governmental control of the Premises; and (5) any new excise, transaction, sales, privilege, or
other tax now or hereafter imposed upon Lessor as a result of this Lease, provided that "Taxes" shall not include any increase in Taxes resulting from a reassessment due to a change in ownership of
the Premises. 

        If
at any time during the term of the Lease the taxation or assessment of the Premises prevailing as of the date of this Lease shall be altered so that in lieu of or in addition to any
Taxes described above there shall be levied, assessed, or imposed (whether by reason of a change in the method of taxation or assessment, creation of new tax or charge, or any other cause) an
alternate, substitute, or additional tax or charge (1) on the value, use or occupancy of the Premises, (2) on or measured by the gross receipts, income, or rentals from the Premises, or
Lessor's business of leasing the Premises, or (3) computed in any manner with respect to the operation of the Premises, then any such tax or charge, however designated, shall be included within
the meaning of the term "Taxes" for purposes of this Lease. 

        Notwithstanding
the foregoing, the term "Taxes" shall not include estate, inheritance, transfer, gift, or franchise taxes of Lessor or the federal or state income tax imposed on Lessor's
income from all sources. 

        (d)   The
following costs ("Costs") shall be excluded from the definition of Operating Expenses: 

        (1)   Costs
occasioned by the act, omission or violation of law by Lessor, or its respective agents, employees or contractors; 

        (2)   Costs
for which Lessor receives reimbursement from Lessee or from others, including reimbursement from insurance; 

        (3)   Interest,
charges and fees incurred on debt or payments on any deed of trust or ground lease on the Premises of which Lessor is debtor, trustor, or lessor; 

        (4)   Costs
incurred in repairing, maintaining or replacing any structural elements of the Building for which Lessor is responsible pursuant to Paragraph 13(a) hereof
and costs incurred by Lessor in restoring the Building after a casualty loss; 

        (5)   Any
wages, bonuses or other compensation of employees of Lessor, including fringe benefits, or any fee, office overhead or general and administrative expenses paid to
Lessor or its affiliates for management and administration of the Premises in excess of the management fee referred to in Paragraph 4(b) of this Lease; 

        (6)   Costs
incurred to correct any defects in the Premises of which Lessee gives Lessor written notice prior to the expiration of the warranty period referred to in
Paragraph 12(c) hereof; 

        (7)   Costs
to correct any construction defect in the Premises resulting from construction performed after the Commencement Date pursuant to any construction contract to which
Lessor is the owner party; 

3

 

        (8)   Costs
in the nature of depreciation, amortization or other expense reserves; and 

        (9)   Costs
incurred as a result of casualties or by the exercise of the power of eminent domain. 

        Lessor
shall at all times use its best efforts to operate the Premises in an economically reasonable manner at costs not disproportionately higher than those experienced by other
comparable premises in the market area in which the Premises are located. 

        (e)   During
December of each calendar year of the term, commencing December 2002, Lessor shall notify Lessee in writing of Lessor's good faith estimate of the
Operating Expenses and Taxes for the following calendar year. Lessor shall include with such notice a description of the Operating Expenses and Taxes. Commencing on January 1, 2003, and on the
first (1st) day of every calendar month of the term
thereafter, Lessee shall pay to Lessor monthly in advance, as Additional Rent, one-twelfth (1/12th) of the estimated Operating Expenses and Taxes for the current calendar year. If during
the term it appears to Lessor that the Operating Expenses or Taxes for the current calendar year will vary from Lessor's estimate, Lessor may, by written notice to Lessee, revise Lessor's estimate
Operating Expenses or Taxes for the current calendar year and the Additional Rent and Taxes payments by Lessee for such calendar year shall thereafter be based upon such revised estimate. Lessor shall
furnish to Lessee with such revised estimate written documentation supporting Lessor's revised estimate. The increase in the monthly installments of Additional Rent and Taxes resulting from Lessor's
revised estimate shall not be retroactive, but the Additional Rent and Taxes for such calendar year shall be subject to adjustment between Lessor and Lessee following the end of each calendar year as
provided below. 

        Within
ninety (90) days after the end of each calendar year during the term, Lessor shall furnish Lessee a statement certified by a responsible employee or agent of Lessor (the
"Operating Statement") with respect to the term of the Lease prepared by an employee or agent of Lessor, showing Operating Expenses and Taxes for the prior calendar year broken down by component
expenses, and the total payments made by Lessee on the basis of any previous estimate of such Operating Expenses and Taxes, all in sufficient detail for verification by Lessee. Unless Lessee raises
any objections to the Operating Statement within thirty (30) days after Lessee's receipt of the Operating Statement, such statement shall conclusively be deemed correct and Lessee shall have no
right thereafter to dispute such statement or any item therein or the computation of Operating Expenses and/or Taxes. Lessee and its accountants shall have the right to inspect and audit Lessor's
books and records with respect to this Lease once within thirty (30) days after Lessee's receipt of the Operating Statement to verify actual Operating Expenses and/or Taxes for the prior
calendar year. Lessor's books and records shall be kept in accordance with generally accepted accounting principles. If Lessee's audit of the Operating Expenses and/or Taxes reveals a net overcharge
of more than five percent (5%), Lessor promptly shall reimburse Lessee for the reasonable cost of the audit; otherwise, Lessee shall bear the cost of Lessee's audit. In addition to Lessee's audit
rights, Lessor shall, at Lessee's request from time to time, meet and confer with Lessee to review and discuss Operating Expenses and Taxes and the management, maintenance, and repair of the Premises
so that Operating Expenses and Taxes can be maintained at a commercially reasonable level. 

        Within
thirty (30) days after Lessee's receipt of Lessor's Operating Statement or the completion of Lessee's audit regarding the Operating Expenses and/or Taxes for each calendar
year during the term of this Lease or the period through the Expiration Date or termination date of this Lease, Lessee shall pay to Lessor or shall receive from Lessor, as the case may be, an amount
equal to the difference between the Operating Expenses and/or Taxes for the calendar year or period, as finally determined, and the amount previously paid by Lessee on account thereof (prorated to the
Expiration Date or the termination date of this Lease). 

4

 

 
        5.    Payment of Rent.    

        (a)   All
rent shall be due and payable by Lessee in lawful money of the United States of America at the address of Lessor set forth in Paragraph 23, "Notices," without
deduction or offset and without prior demand or notice, unless otherwise specified herein. Monthly Base Rent and Additional Rent shall be payable monthly, in advance, on the first (1st) day of each
calendar month. Lessee's obligation to pay rent for any partial month at the commencement or expiration or termination of the Lease term shall be prorated on the basis of the actual number of days in
such calendar month. 

        (b)   If
any installment of Monthly Base Rent, Additional Rent or any other sum due from Lessee is not received by Lessor within five (5) days after receipt by Lessee
of written notice from Lessor that the same is due, Lessee shall pay to Lessor an additional sum equal to five percent (5%) of the amount overdue as a late charge. The parties agree that this late
charge represents a fair and reasonable estimate of the costs that Lessor will incur by reason of the late payment by Lessee. Acceptance of any late charge shall not constitute a waiver of Lessee's
default with respect to the overdue amount. Any amount not paid within five (5) days after Lessee's receipt of written notice that such amount is due shall bear interest from the date due until
paid at the lesser rate of (1) the prime rate of interest plus five percent (5%) or (2) the maximum rate allowed by law, in addition to the late payment charge (the "Interest Rate"). 

 

 

													
	 	 	Initials:	 	Lessor	 	HB	 	Lessee	 	LD DPP	 	 
	 	 	 	 	 	 	

  	 	 	 	

  	 	 

 

         6.    Letter of Credit.    

        (a)   Concurrently
with the execution and delivery of this Lease, Lessee shall deliver to Lessor as security for the payment by Lessee of the rent or any other sum due and
owing during the term of this Lease, an irrevocable and unconditional letter of credit governed by the Uniform Customs and Practice for Documentary Credits (1993 revisions), International Chamber of
Commerce Publication No. 500, as revised from time to time, in the amount of Fifty-five Thousand Eighty Dollars ($55,080) (the "Letter of Credit") naming Lessor as beneficiary. The
form of the Letter of Credit and the issuer thereof shall be subject to approval by Lessor. 

        (b)   The
amounts necessary for Lessor to recover any rent or other sum in default (beyond applicable notice and cure periods), or to recover the payment of any amount that
Lessor may spend or may become obligated to spend by reason of Lessee's uncured default (beyond applicable notice and cure periods) or to compensate Lessor for any loss or damage which Lessor has
suffered thereby shall be available under the Letter of Credit to Lessor upon presentation to the issuer of Lessor's sight draft accompanied only by the Letter of Credit and Lessor's signed statement
that Lessor is entitled to draw on the Letter of Credit pursuant to this Lease. The Letter of Credit shall be maintained in effect, whether through renewal or extension, for the entire period from the
Commencement Date of this Lease and continuing until the date (the "LC Expiration Date") which is one hundred twenty (120) days after the expiration of the Lease term, and Lessee shall deliver
a new Letter of Credit or certificate of renewal or extension to Lessor at least thirty (30) days prior to the expiration of the Letter of Credit then held by Lessor, without any action
whatsoever on the part of Lessor. The Letter of Credit shall state that the failure of Lessee to deliver to Lessor a new Letter of Credit or a certificate of renewal or extension at least thirty
(30) days prior to the expiration of the Letter of Credit shall constitute a default by Lessee that shall entitle Lessor to draw the entire amount of the existing Letter of Credit. The Letter
of Credit shall expressly state that the Letter of Credit and the right to draw thereunder may be transferred or assigned by Lessor to any successor or lessee of Lessor's interest in the Premises.
Lessee shall pay any fees related to the issuance or amendment of the Letter of Credit, excluding, however, any transfer fees, which shall be paid by Lessor. If Lessee is not then in Default under 

5

 

this
Lease, Lessor shall return the Letter of Credit to Lessee within thirty (30) days after the end of the term. 

        7.    Use.    Subject to Lessee obtaining at Lessee's sole cost and expense all necessary governmental permits and
approvals therefor, Lessee shall have the right to use the Premises for general office use, laboratory use (including, without limitation, tissue culture, radiation facilities and chemistry
laboratories), research and development, and manufacturing of biotechnology products, keeping of live animals for research purposes and for such other uses permitted by applicable zoning ordinances
and any covenants, conditions, and restrictions affecting the Premises ("Permitted Uses"), and for no other use or purpose without Lessor's prior written consent. Any use of the Premises by any
assignee or sublessee of Lessee pursuant to Paragraph 16 shall comply with the provisions of this Paragraph 7. Except for Lessor's representations and warranties contained in
Paragraph 12(d), Lessor does not make any representation or warranty to Lessee (1) regarding the suitability of the Premises, or the suitability of the electrical and other systems of
the Building, for Lessee's Permitted Uses thereof, or (2) that the Premises may be lawfully used for Lessee's intended purposes, and Lessor shall have no liability whatsoever to Lessee if any
such use is not permitted by applicable zoning or under any other law or ordinance, and this Lease shall not be construed to imply any such representation or warranty. 

        8.    Environmental Matters.    

        (a)   The
term "Hazardous Materials" as used in this Lease shall mean any product, substance, or waste whose presence, use, manufacture, disposal, transportation, or release,
is regulated or monitored by any governmental authority pursuant to Environmental Laws. Hazardous Materials shall include, but not be
limited to hydrocarbons, petroleum, gasoline, and/or crude oil or any products, by-products or fractions thereof. 

        (b)   "Environmental
Laws" shall mean and include any Federal, State, or local statute, law, ordinance, code, rule, regulation, order, or decree regulating, relating to, or
imposing liability or standards of conduct concerning, any hazardous, toxic, or dangerous waste, substance, element, compound, mixture or material, as now or at any time hereafter in effect including,
without limitation, California Health and Safety Code §§25100 et seq., §§25300 et seq., Sections 25281(f) and 25501 of the California Health and Safety
Code, Section 13050 of the Water Code, the Federal Comprehensive Environmental Response, Compensation and Liability Act, as amended, 42 U.S.C. §§9601 et seq. ("CERCLA"),
the Superfund Amendments and Reauthorization Act, 42 U.S.C. §§9601 et seq., the Federal Toxic Substances Control Act, 15 U.S.C. §§2601 et seq., the
Federal Resource Conservation and Recovery Act as amended, 42 U.S.C. §§6901 et seq., the Federal Hazardous Material Transportation Act, 49 U.S.C. §§1801
et seq., the Federal Clean Air Act, 42 U.S.C. §7401 et seq., the Federal Water Pollution Control Act, 33 U.S.C. §1251 et seq., the River and Harbors Act of 1899, 33 U.S.C.
§§401 et seq., and all rules and regulations of the EPA, the California Environmental Protection Agency, or any other state or federal department, board or any other agency or
governmental board or entity generally having jurisdiction over the environment, as any of the foregoing have been, or are hereafter amended. 

        (c)   Lessee
shall not use, store, or transport to or from the Premises, or dispose of any Hazardous Materials except the Hazardous Materials listed on Exhibit "C" attached
hereto and incorporated by reference herein, and ordinary and customary office supplies and cleaning materials which are used in the normal course of Lessee's agreed use of the Premises. All such
Hazardous Materials (1) shall be used, stored, transported, and disposed of in strict compliance with Environmental Laws, and (2) shall be stored on the Premises only in limited quantity
required for the business at the Premises. Except as listed on Exhibit "C," as Exhibit "C" may be amended and supplemented from time to time with Lessor's prior written consent, and except as
otherwise specifically permitted by this Paragraph 8(c), Lessee shall not use, store, transport, or dispose of any Hazardous Materials in or about the Premises. Without limiting the generality
of the 

6

 

foregoing,
Lessee shall, at its sole cost, comply with all Environmental Laws relating to Hazardous Materials that Lessee uses, stores, transports, or disposes in or about the Premises. If Hazardous
Materials are discovered at or about the Premises in violation of Environmental Laws and such Hazardous Materials were used, stored, transported, or disposed of by Lessee, then Lessee shall, at
Lessee's sole expense, promptly take all action necessary to cause the Premises to comply with all Environmental Laws with respect to such Hazardous Materials and if and such Hazardous Materials were
not used, stored, transported, or disposed of by Lessee, then Lessor shall take all action necessary to cause the Premises to comply with all Environmental Laws with respect to such Hazardous
Materials. Lessee shall deliver to Lessor a copy of Lessee's current Hazardous Materials Management Plan, and any amendments or supplements thereto, or replacements thereof, from time to time during
the term of this Lease, and a copy of all Hazardous Materials reports or plans filed by Lessee with the City of Palo Alto, even though Lessee's Hazardous Materials Management Plan and any such reports
on plans filed with the City show that Lessee is not currently using any reportable Hazardous Materials
on the Premises. Lessee shall not be responsible for the containment of or any other disposal or remediation measures relating to Hazardous Materials used, stored, transported, or disposed of on the
Premises by previous lessees or by Lessor. Lessor shall provide Lessee with a copy of the closure plan implemented by the previous lessee of the Premises and any related reports and certificates from
governmental authorities relating to such closure. 

        (d)   If
Lessee knows, or has reasonable cause to believe, that Hazardous Materials have come to be located in, on, under or about the Premises, other than as shown on Exhibit
"C" or previously approved in writing by Lessor, Lessee shall immediately give written notice of such fact to Lessor and provide Lessor with a copy of any report, notice, claim or other documentation
which it has concerning the presence of such Hazardous Materials. 

        (e)   Lessee
shall indemnify, defend with counsel reasonably acceptable to Lessor, and hold Lessor harmless from any and all claims, damages, fines, judgments, penalties,
costs, liabilities or losses (including, without limitation, any and all sums paid for settlement of claims, attorneys' fees, consultant and expert fees) arising during or after the term (as such may
be extended) from the use, storage, transportation, release, disposal, discharge, or emission of Hazardous Materials at or about the Premises by Lessee, or Lessee's employees, agents, contractors, or
invitees. Without limitation of the foregoing, this indemnification shall include any and all costs incurred due to any investigation of the site or any cleanup, removal or restoration mandated by a
federal, state or local agency or political subdivision and any repairs to the Premises required in connection therewith. The foregoing indemnity shall survive the expiration or earlier termination of
this Lease. 

        (f)    Lessor
represents and warrants that, to the best of Lessor's knowledge as of the date of this Lease, (1) no Hazardous Materials are currently present in the
Building or at the Premises, or the soil, surface water, or ground water thereof; (2) no underground storage tanks are present at the Premises; and (3) no action, proceeding, or claim is
pending or threatened regarding the Building or the Premises concerning any Hazardous Materials or pursuant to any Environmental Law. 

        (g)   Prior
to the expiration of the term and the surrender of possession of the Premises by Lessee to Lessor, Lessee shall obtain at Lessee's expense an environmental closure
report certified by the appropriate department of the City of Palo Alto and a copy of such certification shall be delivered to Lessor. Such closure shall include the removal and remediation at
Lessee's expense, in accordance with and to the extent required by applicable laws and governmental regulatory agencies, of any Hazardous Materials in, on, under, or about the Premises released or
discharged by Lessee, its Permitted Affiliates, sublessees, assignees, employees, agents, contractors, or invitees. 

7

 

        (h)   The
provisions of this Paragraph 8 shall survive the expiration or earlier termination of the term of this Lease. 

        9.    Taxes on Lessee's Property.    Lessee shall pay before delinquency any and all taxes, assessments, license fees,
and public charges levied, assessed, or imposed and which become payable during the term upon Lessee's equipment, fixtures, furniture, and personal property installed or located in the Premises and
any such property owned by Lessor. 

        10.    Insurance.    

        (a)   Lessee
shall, at Lessee's sole cost and expense, provide and keep in force commencing with the date of Lessee's early entry to the Premises pursuant to
Paragraph 1(b) hereof and continuing during the Lease term, a commercial general liability insurance policy with a recognized casualty insurance company qualified to do business in California,
insuring against any and all liability occasioned by any occurrence in, on, about, or related to the Premises, or arising out of the condition, use, occupancy, alteration or maintenance of the
Premises, having a combined single limit for both bodily injury and property damage in an amount not less than Three Million Dollars ($3,000,000). Lessee's liability insurance policy shall contain
cross liability endorsements, shall insure performance by Lessee of the indemnity agreements contained in Paragraph 11(a), and shall name Lessor and Lessor's property manager as additional
insureds. All such insurance carried by Lessee shall be in a form reasonably satisfactory to Lessor and its mortgage lender and shall be carried with companies that have a general policyholder's
rating of not less than "A" and a financial rating of not less than Class "X" in the most current edition of Best's Insurance Reports; shall provide that such policies shall not be subject to material
alteration or cancellation except after at least thirty (30) days' prior written notice to Lessor; and shall be primary and not contributory. Prior to the Commencement Date and upon renewal of
such policies not less than fifteen (15) days prior to the expiration of the term of such coverage, Lessee shall deliver to Lessor certificates of insurance confirming such coverage, together
with evidence of the payment of the premium therefor. If Lessee fails to procure and maintain the insurance required hereunder, Lessor may, but shall not be required to, order such insurance at
Lessee's expense and Lessee shall reimburse Lessor for all costs incurred by Lessor with respect thereto. Lessee's reimbursement to Lessor for such amounts shall be deemed Additional Rent, and shall
include all sums disbursed, incurred or deposited by Lessor, including Lessor's costs, expenses and reasonable attorneys' fees with interest thereon at the Interest Rate. 

        (b)   Lessor
shall obtain and carry in Lessor's name, as insured, as an Operating Expense of the Premises as provided in Paragraph 4(b), during the lease term, "all
risk" property insurance coverage (with rental loss insurance coverage for a period of one year), flood insurance, public liability and property damage insurance, and insurance against such other
risks or casualties as Lessor shall determine, including, but not limited to, insurance coverages required of Lessor by the beneficiary of any deed of trust which encumbers the Property (excluding
earthquake insurance coverage), insuring Lessor's interest in the Premises, any other improvements to the Premises constructed by Lessor, or by Lessee with Lessor's prior written approval, in an
amount not less than the full replacement cost of the Building and all other Improvements from time to time. The proceeds of any such insurance shall be payable solely to Lessor and Lessee shall have
no right or interest therein. Lessor shall have no obligation to insure against loss by Lessee to Lessee's equipment, furniture, fixtures, inventory, or other personal property of Lessee in, on, or
about the Premises occurring from any cause whatsoever. Lessor's commercial
general liability insurance shall provide for contractual liability referred to in Paragraph 11(b) of this Lease. 

8

 

 

        (c)   Notwithstanding
anything to the contrary contained in this Lease, the parties release each other, and their respective authorized representatives, employees, officers,
directors, shareholders, managers, members, assignees, subtenants, and property managers, from any claims for damage to any person or to the Premises and to the fixtures, personal property, leasehold
improvements and alterations of either Lessor or Lessee in or on the Premises that are caused by or result from risks required by this Lease to be insured against or actually insured against under any
property insurance policies carried by the parties and in force at the time of any such damage, whichever is greater. This waiver applies whether or not the loss is due to the negligent acts or
omissions of Lessor or Lessee or their respective officers, directors, employees, agents, contractors, or invitees. 

        (d)   Each
party shall cause each property insurance policy obtained by it to provide that the insurance company waives all right of recovery by way of subrogation against
either party in connection with the above waiver and any damage covered by any policy; provided, however, that such provision or endorsement shall not be required if the applicable policy of insurance
permits the named insured to waive rights of subrogation on a blanket basis, in which case the blanket waiver shall be acceptable. Neither party shall be liable to the other for any damage caused by
fire or any of the risks insured against under any policy of insurance carried pursuant to this Lease. 

        11.    Indemnification.    

        (a)   Lessee
waives all claims against Lessor for damage to or loss of Lessee's equipment, furniture, fixtures, supplies, product inventory, or other personal property of
Lessee or any other person in, upon, or about the Premises, and for injuries to persons in, upon, or about the Premises from any cause arising at any time, except as may be caused by the negligence or
willful misconduct of Lessor or its employees, agents or contractors, or Lessor's failure to perform any of its obligations under this Lease or that arise from any breach of any of Lessor's
warranties. Except as provided in Paragraph 10(c), Lessee shall indemnify, defend, and hold harmless ("Indemnify") Lessor from claims, suits, actions, or liabilities (collectively, "Losses")
for personal injury, death or for loss or damage to property that arise from (1) any activity, work, or thing done, or permitted by Lessee in or about the Premises, (2) for bodily injury
or damage to property which arises in or about the Building or the Premises to the extent
the injury or damage to property results from the negligent acts or omissions of Lessee, its employees, agents or contractors, and (3) arising from a breach of this Lease by Lessee in the
performance of any obligation on Lessee's part to be performed under this Lease, provided, however, that Lessee shall not be responsible to Indemnify Lessor for any Losses caused by the negligence or
willful misconduct of Lessor or its employees, agents or contractors, or Lessor's failure to perform any of its obligations or breach of any warranty by Lessor under this Lease. 

        (b)   Except
as provided in Paragraph 10(c), Lessor shall indemnify, defend, and hold harmless Lessee from claims, suits, actions, or liabilities for personal injury,
death or for loss or damage to property except as may be caused by the negligence or willful misconduct of Lessee or its employees, agents, or contractors, or Lessee's failure to perform any of its
obligations or breach of any warranty by Lessee under this Lease. 

        (c)   The
foregoing indemnities by Lessee and Lessor shall also include reasonable costs, expenses and attorneys' fees incurred in connection with any indemnified claim or
incurred by the indemnitee in successfully establishing the right to indemnity. The indemnitor shall have the right to assume the defense of any claim subject to the foregoing indemnities with counsel
reasonably satisfactory to the indemnitee. The indemnitee agrees to cooperate fully with the indemnitor and its counsel in any matter where the indemnitor elects to defend, provided the indemnitor
shall promptly reimburse the indemnitee for reasonable costs and expenses incurred in connection with its duty to cooperate. 

9

 

        The
foregoing indemnities are conditioned upon the indemnitee providing prompt notice to the indemnitor of any claim or occurrence that is likely to give rise to a claim, suit, action or
liability that will fall within the scope of the foregoing indemnities, along with sufficient details that will enable the indemnitor to make a reasonable investigation of the claim. 

        When
the claim is caused by the joint negligence or willful misconduct of Lessee and Lessor or by the indemnitor party and a third party unrelated to the indemnitor party (except
indemnitor's agents, officers, employees or invitees), the indemnitor's duty to indemnify and defend shall be proportionate to the indemnitor's allocable share of joint negligence or willful
misconduct. 

        (d)   Notwithstanding
anything to the contrary contained herein, Lessor shall not be liable to Lessee, or to any of Lessee's employees, agents, contractors, or invitees for
any damage because of any act or negligence of any owner or occupant of adjoining or contiguous property or other third person, or for overflow, breakage, or leakage of water, steam, gas, or
electricity from pipes, wires, or otherwise in the Premises or the Building. 

        12.    Condition of the Premises.    

        (a)   Lessor
shall deliver the Premises to Lessee on the Commencement Date with the Building in broom clean condition. Prior to the Commencement Date Lessor, at its cost,
shall: (1) cause the trailers in the parking lot to be removed; (2) remove and retreat the windows with proper coating; (3) power wash the exterior of the Building;
(4) review and replace the landscaping as needed and place the sprinkler system in working condition; (5) repaint the accent stripe on the exterior of the Building; and
(6) inspect the parking lot and seal and restripe the parking lot if necessary. 

        (b)   Lessor
shall also construct at Lessor's expense ten (10) offices in the right front section of the existing office area of the Building. Lessor shall be
responsible for installation of sprinklers if required by the building code relating to Lessor's tenant improvement work. 

        (c)   If
Lessor's tenant improvement work, Lessee's tenant improvement work, or Lessee's proposed use of the Premises as described in Paragraph 7, triggers the
requirement under the building code for seismic upgrading of the Building or the requirement that sprinklers be installed elsewhere in the Building, Lessor and Lessee shall each pay
one-half of (1) the cost of the seismic upgrading, and (2) the cost of installation of the additional sprinklers required, in addition to the sprinklers to be installed by
Lessor pursuant to Paragraph 12(b) if required. 

        (d)   Lessor
represents and warrants to Lessee that (1) the HVAC system and the mechanical, electrical, gas (if any), and plumbing systems of the Building shall be in
good working order as of the Commencement Date, (2) the structural elements of the roof, bearing walls and foundation of the Building shall be free of material defects as of the Commencement
Date, (3) the tenant improvement work performed by Lessor pursuant to Paragraphs 12(a) and 12(b) shall be completed in a good and workmanlike manner, and (4) to Lessor's knowledge, the
telephone, water, sewer, electricity, gas, and other utility lines connected to the Building are in good working order from edge of Lessor's property to their point of connection in the Building
walls. If a noncompliance with such warranty exists as of the Commencement Date, or if one of such systems or elements should malfunction or fail, or a material defect in Lessor's tenant improvement
work performed pursuant to Paragraphs 12(a) or 12(b) should become apparent, within ninety (90) days after the Commencement Date, Lessor shall, as Lessor's sole obligation with respect to such
matter, except as otherwise provided in this Lease, promptly after receipt of written notice from Lessee setting forth with specificity the nature and extent of such non-compliance,
malfunction, failure, or defect, rectify the same at Lessor's expense. If Lessee does not give Lessor the required notice within the ninety (90) day warranty period, correction of any such
non-compliance, 

10

 

malfunction,
failure, or defect shall be performed by Lessor and the cost thereof shall be an Operating Expense payable by Lessee pursuant to Paragraph 4 hereof. 

        (e)   Lessor
shall make available to Lessee for Lessee's use without additional charge the existing furniture, fixtures, and equipment listed on Exhibit "D" attached hereto in
its "as is" condition as of the Commencement Date. Such property shall remain the property of Lessor and shall be surrendered to Lessor upon the expiration or sooner termination of the term of this
Lease in a condition comparable to the condition of such property on the Commencement Date, reasonable wear and tear excepted. 

        (f)    Except
for the foregoing provisions of this Paragraph 12, Lessee shall accept the Premises on the Commencement Date in its "as is" condition. Lessee shall install
at Lessee's sole expense the initial improvements described on Exhibit "E" attached hereto and made a part hereof, and any additional laboratory upgrades, including, but not limited to, installation
of gas lines, sinks, and laboratory benches required for Lessee's Permitted Uses of the Premises, including, but not limited to, Lessee's chemistry and biology laboratories and animal facility. 

        (g)   Lessee
waives all right to make repairs at the expense of Lessor (except as set forth in Paragraph 28 below), or to deduct the costs thereof from the rent, and
Lessee waives all rights under Section 1941 and 1942 of the Civil Code of the State of California. 

        13.    Maintenance and Repairs; Alterations; Surrender and Restoration.    

        (a)   Lessor
shall, at Lessor's expense, keep in good order, condition, and repair and replace when necessary, the structural elements of the foundation and exterior walls
(except the interior faces thereof) of the Building, excluding any alterations, structural or otherwise, made by Lessee to the Building which are not approved in writing by Lessor prior to the
construction or installation thereof by Lessee. 

        (b)   In
addition to the items referred to in Paragraph 4(b), Lessor shall repair and maintain as an Operating Expense pursuant to Paragraph 4 hereof, the roof
and the roof membrane, the areas of the Premises outside the Building, including the landscaping, tree trimming, resurfacing and restriping of the parking lot and walkways, exterior building lighting,
and parking lot lighting (subject to amortization of the cost thereof if the cost is a capital expenditure as provided in Paragraph 4(b)). In the event Lessee provides Lessor with written
notice of the need for any repairs to the Premises, Lessor shall commence any such repairs promptly following receipt by Lessor of such notice and Lessor shall diligently prosecute such repairs to
completion. 

        (c)   Subject
to the foregoing and except as provided elsewhere in this Lease, Lessee shall at all times at Lessee's expense keep the Premises in good and safe order,
condition, and repair. Lessee shall contract for and pay directly for the janitorial service to the Building. Lessee shall execute and maintain in full force and effect at Lessee's expense throughout
the term a service contract with an authorized air conditioning service company for periodic service, repairs, and replacement of parts. Lessor shall have the right to obtain on a
semi-annual basis an inspection report of the HVAC system
from an HVAC service firm designated by Lessor for the purpose of monitoring the performance of the HVAC maintenance and repair work performed by Lessee's HVAC service firm. The cost of such
inspection report shall be an Operating Expense pursuant to Paragraph 4(b). Subject to the release of claims and waiver of subrogation contained in Paragraphs 10(c) and 10(d), if Lessor is
required to make any repairs by reason of Lessee's negligent acts or omission to act, Lessor may add the cost of such repairs to the next installment of rent which shall thereafter become due, and
Lessee shall promptly pay the same upon receipt of an invoice therefor. 

        (d)   Lessee
may, from time to time, at its own cost and expense and without the consent of Lessor make nonstructural alterations to the interior of the Premises the cost of
which in any one 

11

 

instance
is Fifty Thousand Dollars ($50,000) or less, and the aggregate cost of all such work during the term of this Lease does not exceed Two Hundred Fifty Thousand Dollars ($250,000), provided
Lessee first notifies Lessor in writing of any such nonstructural alterations. Otherwise, Lessee shall not make any additional alterations, improvements, or additions to the Premises without
delivering to Lessor a complete set of plans and specifications for such work and obtaining Lessor's prior written consent thereto, which consent shall not be unreasonably withheld or delayed. If any
nonstructural alterations to the interior of the Premises exceed Fifty Thousand Dollars ($50,000) in cost in any one instance, or exceed the aggregate cost of Two Hundred Fifty Thousand Dollars
($250,000) during the term of this Lease, Lessee shall employ, at Lessee's expense, a qualified licensed general contractor to perform such alterations pursuant to a construction contract entered into
between Lessee and such contractor. The contractor and the construction contract shall be subject to Lessor's written approval prior to commencement of construction, which approval shall not be
unreasonably withheld or delayed. Lessor may condition its consent to Lessee agreeing in writing to remove any such alterations prior to the expiration of the Lease term and Lessee agreeing to restore
the Premises to its condition prior to such alterations at Lessee's expense. Lessor shall advise Lessee in writing at the time consent is granted whether Lessor reserves the right to require Lessee to
remove any alterations from the Premises prior to the termination of this Lease. 

        All
alterations, trade fixtures and personal property installed in the Premises solely at Lessee's expense shall during the term of this Lease remain the property of Lessee, and Lessee
shall be entitled to all depreciation, amortization and other tax benefits with respect thereto. Lessee may remove any of Lessee's personal property, furniture, or equipment which is not affixed to
the Building in such a manner that it becomes a part of the Improvements ("Lessee's Personal Property") at any time and from time to time. Lessor shall have no lien or other interest whatsoever in any
item of Lessee's Personal Property. Within ten (10) days following Lessee's request from time to time, Lessor shall execute documents in commercially reasonable form to evidence Lessor's waiver
of any right, title, lien or interest in any of Lessee's Personal Property and giving any lenders holding a security interest or lien on such property reasonable rights of access to the Premises to
remove Lessee's Personal Property, provided that such lenders agree to repair all damage caused by such removal. Upon the expiration or sooner termination of this Lease all alterations, fixtures and
improvements to the Premises, whether made by Lessor or installed by Lessee at Lessee's expense, shall be surrendered by Lessee with the Premises and shall become the property of Lessor, provided,
however, that Lessee shall retain ownership or (1) Lessee's Personal Property, (2) any alterations, fixtures or improvements that, at the time of installation or thereafter, Lessor has
agreed that Lessee may retain ownership of and may remove, and (3) any alterations, fixtures or improvements that Lessor requires Lessee to remove. 

        (e)   Lessee,
at Lessee's sole cost and expense, shall during the term of this Lease promptly and properly observe and comply with all existing and future orders, regulations,
rules, laws, and ordinances of all governmental agencies or authorities, and the Board of Fire Underwriters ("Laws"). Any structural changes or repairs or other repairs or changes of any nature which
would be considered a capital expenditure under generally accepted accounting principles to the Premises shall be made by Lessor at Lessee's expense if such structural repairs or changes are required
by reason of the specific nature of the use of the Premises by Lessee. If such structural changes or repairs are not required by reason of the specific nature of Lessee's use of the Premises, the cost
of such structural changes or repairs, except as provided in Paragraph 13(a), shall be treated as an Operating Expense, and if such work is a capital expenditure the cost thereof shall be
amortized in accordance with the provisions of Paragraph 4(b). 

        (f)    Lessee
shall surrender the Premises by the last day of the Lease term or any earlier termination date, with all of the improvements to the Premises, parts, and surfaces
thereof clean 

12

 

and
free of debris and in good operating order, condition, and state of repair, ordinary wear and tear excepted. "Ordinary wear and tear" shall not include any damage or deterioration that would have
been prevented by good maintenance practice or by Lessee performing all of its obligations under this Lease. The obligations of Lessee shall include the repair of any damage occasioned by the
installation, maintenance, or removal of Lessee's trade fixtures, furnishings, equipment, and alterations, and the restoration by Lessee of the Premises to its condition prior to any alterations,
additions, or improvements (1) if Lessor's consent thereto was conditioned upon such removal and restoration upon expiration or sooner termination of the Lease term pursuant to
Paragraph 13(d), or (2) if Lessee made any such alterations, additions, or improvements without obtaining Lessor's prior written consent in breach of Paragraph 13(d) and within a
reasonable time after the expiration or sooner termination of the Lease term Lessor gives written notice to Lessee requiring Lessee to perform such removal and restoration. 

        14.    Utilities and Services.    

        (a)   Lessee
shall contract for and pay for all electricity, telephone, gas, water, heat and air conditioning service, janitorial service, refuse pick-up, sewer
charges, and all other utilities or services supplied to or consumed by Lessee, its agents, employees, contractors, and invitees on or about the Premises. 

        (b)   Lessor
shall not be liable to Lessee for any interruption or failure of any utility services to the Building or the Premises which is not caused by the negligence or
willful acts of Lessor, or Lessor's employees, agents, or contractors. Lessee shall not be relieved from the performance of any covenant or agreement in this Lease because of any such interruption or
failure, unless the interruption or failure is caused by the negligence or willful acts of Lessor, or Lessor's employees, agents, or
contractors in which case Lessee shall be entitled, in addition to any other remedy at law, to an abatement or rent in proportion to and for the duration of time that the interruption or failure
prevents Lessee from using the Premises for the Permitted Uses. 

        15.    Liens.    Lessee agrees to keep the Premises free from all liens arising out of any improvement work performed
by Lessee or arising out of any other work performed, materials furnished, or obligations incurred by Lessee. Lessee shall give Lessor at least ten (10) days prior written notice before
commencing any work of improvement on the Premises, the contract price for which exceeds Ten Thousand Dollars ($10,000). Lessor shall have the right to post notices of non-responsibility
with respect to any such work. If Lessee shall, in good faith, contest the validity of any such lien, claim or demand, then Lessee shall, at its sole expense, defend and protect itself, Lessor and the
Premises against the same, and shall pay and satisfy any such adverse judgment that may be rendered thereon or provide a lien release bond in accordance with applicable law before the enforcement
thereof against the Lessor or the Premises. 

        16.    Assignment and Subletting.    

        (a)   Except
as otherwise provided in this Paragraph 16, Lessee shall not assign this Lease, or any interest therein, voluntarily or involuntarily, and shall not sublet
the Premises or any part thereof, or any right or privilege appurtenant thereto, without the prior written consent of Lessor in each instance pursuant to the terms and conditions set forth below,
which consent shall not be unreasonably withheld, subject to the following provisions. 

        (b)   Prior
to any assignment or sublease which Lessee desires to make, Lessee shall provide to Lessor the name and address of the proposed assignee or sublessee, true and
complete copies of all documents relating to Lessee's prospective agreement to assign or sublease, a copy of a current financial statement for such proposed assignee or sublessee, and Lessee shall
specify all consideration to be received by Lessee for such assignment or sublease in the form of lump sum payments, installments of rent, or otherwise. For purposes of this Paragraph 16, the
term 

13

 

"consideration"
shall include all money or other consideration to be received by Lessee for such assignment or sublease. Within ten (10) days after the receipt of such documentation and other
information, Lessor shall (1) notify Lessee in writing that Lessor elects to consent to the proposed assignment or sublease subject to the terms and conditions hereinafter set forth; or
(2) notify Lessee in writing that Lessor refuses such consent, specifying reasonable grounds for such refusal; or (3) subject to the provisions set forth below, notify Lessee that Lessor
elects to terminate this Lease and specifying the effective date of termination. Upon the effective date of termination Lessor and Lessee shall each be released and discharged from any liability or
obligation to the other under this Lease accruing thereafter, and Lessee agrees that Lessor may enter into a direct lease with such proposed assignee or sublessee without any obligation or liability
to Lessee. Notwithstanding the foregoing, Lessor shall only have the right to terminate this Lease pursuant to the foregoing clause (3) in the event of a proposed assignment by Lessee of its
entire right, title and interest under this Lease, or in the event of a
proposed sublease by Lessee of the entire Premises for the then remaining term of this Lease, or for the then remaining term except for the final thirty (30) days or less thereof, provided that
in no event shall Lessor have any right to terminate this Lease in connection with any transfer permitted under Paragraph 16(h). In addition, if Lessor notifies Lessee pursuant to the foregoing
clause (3) that Lessor elects to terminate this Lease, Lessee shall have the right to rescind its proposed assignment or sublease by giving written notice thereof to Lessor, in which event this
Lease shall remain in full force and effect as if Lessee had never proposed such assignment or sublease. 

        (c)   In
deciding whether to consent to any proposed assignment or sublease, Lessor may take into account whether or not reasonable conditions have been satisfied, including,
but not limited to, the following: 

        (1)   In
Lessor's reasonable judgment, the proposed assignee or subtenant is engaged in such a business, that the Premises, or the relevant part thereof, will be used in such
a manner which complies with Paragraph 7 hereof entitled "Use" and Lessee or the proposed assignee or sublessee submits to Lessor documentary evidence reasonably satisfactory to Lessor that
such proposed use constitutes a permitted use of the Premises pursuant to the ordinances and regulations of the City of Palo Alto; 

        (2)   The
proposed assignee or subtenant shall be a reputable entity or individual with sufficient financial net worth so as to reasonably indicate that it will be able to
meet its obligations under this Lease or the sublease in a timely manner; 

        (3)   The
proposed assignment or sublease shall be subject to approval by Lessor's mortgage lender, if any, if such lender has the right to approve or disapprove proposed
assignments or subleases; 

        (4)   The
proposed assignment or sublease shall expressly prohibit further assignment or subletting of all or any part of the Premises by the assignee or sublessee; and 

        (5)   Lessor's
consent to the assignment or sublease shall be in a separate instrument containing the relevant provisions of this Paragraph 16 and otherwise in form
reasonably acceptable to Lessor and its counsel. 

        (d)   As
a condition to Lessor's granting its consent to any assignment or sublease, (1) Lessor may require that Lessee pay to Lessor, as and when received by Lessee,
fifty percent (50%) of the amount of any excess of the consideration to be received by Lessee in connection with said assignment or sublease over and above the rental amount fixed by this Lease and
payable by Lessee to Lessor, after deducting only reasonable leasing commissions, reasonable attorneys' fees, and other reasonable costs and expenses incurred by Lessee in consummating such assignment
or sublease which are approved in writing by Lessor; and (2) Lessee and the proposed assignee or sublessee shall demonstrate to Lessor's reasonable satisfaction that each of the criteria
referred to in subparagraph (c) above is satisfied. 

14

 

 

        (e)   Each
assignment or sublease agreement to which Lessor has consented shall be an instrument in writing which complies with the provisions of this Paragraph 16 and
in form reasonably satisfactory to Lessor, and shall be executed by both Lessee and the assignee or sublessee, as the case may be. Each such assignment or sublease agreement shall recite that it is
and shall be subject and subordinate to the provisions of this Lease, that the assignee or sublessee accepts such assignment or sublease, that Lessor's consent thereto shall not constitute a consent
to any subsequent assignment or subletting by Lessee or the assignee or sublessee, and, except as otherwise set forth in a sublease approved by Lessor, agrees to perform all of the obligations of
Lessee hereunder (to the extent such obligations relate to the portion of the Premises assigned or subleased), and that the termination of this Lease shall, at Lessor's sole election, constitute a
termination of every such assignment or sublease. 

        (f)    In
the event Lessor shall consent to an assignment or sublease, Lessee shall, except as otherwise provided in Paragraph 16(h), remain primarily liable for all
obligations and liabilities of Lessee under this Lease, including, but not limited to, the payment of rent. 

        (g)   Lessee
hereby stipulates that the foregoing terms and conditions are reasonable and comply with the California Civil Code Section 1951.4. 

        (h)   Notwithstanding
the foregoing, Lessee may, without Lessor's prior written consent, without Lessor having the right pursuant to Paragraph 16(b) above to terminate
this Lease, and without any participation by Lessor in assignment and subletting proceeds, assign this Lease or sublet all or any portion of the Premises to a parent, subsidiary, affiliate, division
or corporation controlled or under common control with Lessee ("Permitted Affiliate"), or to a successor corporation to Lessee by merger, consolidation or reorganization, or to any entity which
acquires all or substantially all of the assets or capital stock of Lessee, provided, that except as specified hereafter, AnaMax, Inc. shall remain primarily liable for all obligations and
liabilities of Lessee under this Lease, including, but not limited to, the payment of rent. Lessee's foregoing rights to assign this Lease or to sublet the Premises shall be subject to the following
conditions: (1) there shall be no uncured Event of Default by Lessee under this Lease; (2) in the case of an assignment or subletting to a Permitted Affiliate, AnaMax, Inc. shall
remain liable to Lessor hereunder, unless as a result of a merger, consolidation, or reorganization AnaMax, Inc. is not
a surviving entity, and in such event the transferee or successor entity to AnaMax, Inc. shall have on the effective date of such transaction a net worth as shown on its current balance sheet
certified by a major independent certified public accounting firm equal to at least the net worth of AnaMax, Inc. as of the date immediately prior to the effective date of such transaction; and
(3) the transferee or successor entity shall expressly assume in writing Lessee's obligations hereunder accruing from and after the effective date of such assignment or subletting. 

        (i)    The
sale or transfer of Lessee's capital stock in a public offering pursuant to an effective registration statement filed by Lessee with the Securities and Exchange
Commission shall not be deemed an assignment, subletting, or other transfer of this Lease or the Premises. 

        (j)    Subject
to the provisions of this Paragraph 16 any assignment or sublease without Lessor's prior written consent shall at Lessor's election be void. The consent
by Lessor to any assignment or sublease shall not constitute a waiver of the provisions of this Paragraph 16, including the requirement of Lessor's prior written consent, with respect to any
subsequent assignment or sublease. If Lessee shall purport to assign this Lease, or sublease all or any portion of the Premises, without Lessor's prior written consent (if such consent is required
hereunder), Lessor may collect rent from the person or persons then or thereafter occupying the Premises and apply the net amount collected to the rent reserved herein, but no such collection shall be
deemed a waiver of Lessor's rights and remedies under this Paragraph 16, or the acceptance of any such 

15

 

purported
assignee, sublessee, or occupant, or a release of Lessee from the further performance by Lessee of covenants on the part of Lessee herein contained. 

        (k)   Lessee
shall not hypothecate or encumber its interest under this Lease or any rights of Lessee hereunder, or enter into any license or concession agreement respecting
all or any portion of the Premises, without Lessor's prior written consent which shall not be unreasonably withheld, subject to all of the provisions of this Paragraph 16. 

        (l)    In
the event of any sale or exchange of the Premises by Lessor and assignment of this Lease by Lessor, Lessor shall, upon providing Lessee with written confirmation by
Lessor's successor in interest to the Premises that Lessor has delivered any security deposit held by Lessor to Lessor's successor in interest, be and hereby is entirely relieved of all liability
under any and all of Lessor's covenants and obligations contained in or derived from this Lease with respect to the period commencing with the consummation of the sale or exchange and assignment. 

        (m)  The
parties acknowledge that Lessor has the remedy described in California Civil Code Section 1951.4 (Lessor may continue the Lease in effect after Lessee's
breach and abandonment and recover rent as it becomes due, if Lessee has right to sublet or assign, subject only to reasonable limitations). 

        17.    Waiver.    The waiver by Lessor or Lessee of any breach of any term, covenant, or condition contained herein
shall not be deemed to be a waiver of such term, covenant, or condition of any subsequent breach of the same or any other term, covenant, or condition contained herein. The subsequent acceptance of
rent hereunder by Lessor shall not be deemed to be a waiver of any preceding breach by Lessee of any term, covenant, or condition of this Lease, other than the failure of Lessee to pay the particular
rent so accepted, regardless of Lessor's knowledge of such preceding breach at the time of acceptance of such rent. 

        18.    Holding Over.    Lessee shall vacate the Premises and deliver the same to Lessor in the condition required by
this Lease upon the expiration or sooner termination of this Lease. In the event of holding over by Lessee after the expiration or termination of this Lease, such holding over shall be on a
month-to-month tenancy and all of the terms and provisions of this Lease shall be applicable during such period, except that Lessee shall pay Lessor as Monthly Base Rent during
such holdover an amount equal to the greater of (1) one hundred fifty percent (150%) of the Monthly Base Rent in effect at the expiration of the term, or (2) the then market rent for
comparable research and development/office space. If such holdover is without Lessor's written consent, Lessee shall be liable to Lessor for all costs and expenses incurred by Lessor as a result of
such holdover. The rental payable during such holdover period shall be payable to Lessor on demand. 

        19.    Damage or Destruction.    

        (a)   In
the event of a total destruction of the Building and Improvements during the Lease term from any cause, either party may elect to terminate this Lease by giving
written notice of termination to the other party within thirty (30) days after the casualty occurs. A total destruction shall be deemed to have occurred for this purpose if the Building and
Improvements of the Premises are destroyed to the extent of seventy-five percent (75%) or more of the full replacement cost thereof or requires the Lessee to relocate ("Relocate") a
substantial amount of its chemistry and biology laboratories or animal facility for more than 30 days. If the Building and Improvements are destroyed to the extent of seventy-five
percent (75%) or more of the full replacement cost or Lessee is required to Relocate and this Lease is not terminated by either Lessor or Lessee, Lessor shall, provided that Lessor receives sufficient
insurance proceeds, repair and restore the Building and Improvements to substantially the condition existing as of the Commencement Date of this Lease in a diligent manner and this Lease shall
continue in full force and effect, except that Monthly Base Rent shall be abated in accordance with Paragraph 19(f) 

16

 

below.
Lessee at its election may, but shall not be obligated to, repair and restore the balance of the Building and Improvements at Lessee's expense, including any leasehold improvements constructed
by Lessee during the term of this Lease, or Lessee may elect to terminate this Lease within thirty (30) days of being informed by Lessor that due to the shortfall in insurance proceeds, Lessor
is only partially rebuilding the Premises. 

        (b)   In
the event of a partial destruction of the Building and Improvements to the Premises to an extent exceeding ten percent (10%), but less than seventy-five
percent (75%) of the full replacement cost thereof, Lessee is not required to Relocate, and provided that the damage can be repaired, reconstructed or restored within one hundred fifty
(150) days after the date of the casualty, Lessor shall have the right at Lessor's option either (1) to repair and restore the Building and Improvements, in which event this Lease shall
continue in full force and effect, except that the Monthly Base Rent shall be abated in accordance with the last sentence of Paragraph 19(f) below, or (2) to terminate this Lease by
giving written notice of termination to Lessee within thirty (30) days after the casualty, subject to the provisions of Paragraph 19(e) below. Lessor's election to repair and restore the
Building and Improvements, or to terminate this Lease, shall be made and written notice thereof shall be given to Lessee within thirty (30) days after the casualty. If Lessor elects to restore,
Lessor's obligation shall be to repair and restore the Building and Improvements to substantially the condition existing as of the Commencement Date not later than 150 days after the date of
the casualty and Lessee shall repair and restore the balance of the Building and Improvements at Lessee's expense, including any Improvements constructed by Lessee during the term of this Lease.
Notwithstanding any provision herein to the contrary, if the casualty occurs in the last twelve (12) months of the term, or if the restoration of the Premises is not expected to be completed
prior to nine (9) months before the Termination Date, either Lessor or Lessee shall have the right to terminate this Lease upon written notice to the other party to be given not more than
thirty (30) days after the date of the casualty, provided, however, that Lessor shall not have such right to terminate if Lessee agrees, in Lessee's discretion, by written notice to Lessor
given within ten (10) days after receipt by Lessee of Lessor's notice of termination, to pay the cost of restoring the Premises to their condition immediately prior to the casualty, less the
amount of the insurance proceeds received by Lessor, if any, on account of the casualty. 

        (c)   If
the Building and the Improvements to the Premises are damaged to an extent exceeding ten percent (10%), but less than seventy-five percent (75%) of the
full replacement cost thereof, but the damage cannot be repaired, reconstructed, or restored within a period of one hundred fifty (150) days after the date of the casualty, either Lessor or
Lessee may terminate this Lease by giving written notice of termination to the other within thirty (30) days after the casualty. 

        (d)   Lessor
shall not have the right to terminate this Lease if (1) the repair or restoration would cost less than ten percent (10%) of the full replacement cost of
the Building, or (2) the cost of the repair or restoration would exceed ten percent (10%) of the full replacement cost, but Lessee agrees to pay the cost of repair in excess of ten percent
(10%) of the full replacement cost and Lessee delivers said sum to Lessor within ten (10) business days after receipt of a written request therefor from Lessor. Any funds contributed by Lessee
for the cost of repair or restoration shall be deposited by Lessor into a separate trust account. Lessee shall have the right to approve all disbursements from said account, which approval shall not
be unreasonably withheld or denied. 

        (e)   Lessor's
obligation to repair and restore the Premises pursuant to the foregoing provisions shall be limited to the improvements existing as of the Commencement Date of
the term of this Lease. Lessee at its option may, but shall not be required to, repair or replace, at Lessee's expense, all leasehold improvements, fixtures, and equipment installed by either Lessor
or Lessee after the date of this Lease. If this Lease is not terminated by Lessor or Lessee pursuant to the foregoing provisions, Lessor shall complete the repairs in a diligent manner and this Lease
shall continue in full force and effect, except that Monthly Base Rent shall be abated in 

17

 

accordance
with Paragraph 19(f) below. Lessor's time for completion of the repairs and restoration of the Premises shall be extended by a period equal to any delays caused by strikes, labor
disputes, unavailability of materials, inclement weather, acts of God, or other causes beyond Lessor's control. 

        (f)    In
the event of repair, reconstruction, or restoration as provided herein, the Monthly Base Rent and Additional Rent shall be abated proportionally in the ratio which
the Lessee's use of the Premises is impaired during the period of such repair, reconstruction, or restoration. In the event of termination of this Lease pursuant to any of the provisions of this
Paragraph 19, the Monthly Base Rent shall be apportioned on a per diem basis and shall be paid to the date of the casualty. In no event shall Lessor be liable to Lessee for any damages
resulting to Lessee from the occurrence of such casualty, or from the repairing or restoration of the Building and Improvements, or from the termination of this Lease as provided herein, nor shall
Lessee be relieved thereby from any of Lessee's obligations hereunder, except to the extent and upon the conditions expressly set forth in this Paragraph 19. 

        (g)   The
parties waive their rights under applicable law to the extent inconsistent with the foregoing provisions. 

        20.    Eminent Domain.    

        (a)   If
the whole or any substantial part of the Building shall be taken or condemned by any competent public authority for any public use or purpose, the term of this Lease
shall end upon the earlier to occur of the date when the possession of the part so taken shall be required for such use or purpose or the vesting of title in such public authority. Rent shall be
apportioned as of the date of such termination. Lessee shall be entitled to receive any damages separately awarded by the court for (1) leasehold improvements installed at Lessee's expense or
other property owned by Lessee, (2) reasonable costs of moving by Lessee to another location as agreed upon by Lessee in Santa Clara County or San Mateo County, California, and (3) any
portion of the award made to compensate loss of Lessee's business. The entire balance of the award shall be the property of Lessor. 

        (b)   If
there is a partial taking of the Premises by eminent domain which is not a substantial part of the Building and the balance of the Premises remains reasonably
suitable for continued use and occupancy by Lessee for the purposes referred to in Paragraph 7, Lessor shall complete any necessary repairs in a
diligent manner and this Lease shall remain in full force and effect with a just and proportionate abatement of the Monthly Base Rent and Additional Rent, to reflect the number of square feet of the
Building taken and the number of square feet remaining. If after a partial taking, the Premises are not reasonably suitable for Lessee's continued use and occupancy for the uses permitted herein,
Lessee may terminate this Lease effective on the earlier of the date title vests in the public authority or the date possession is taken. Subject to Lessee's entitlement to receive any damages
separately awarded to Lessee by the court as set forth in Paragraph 20(a), the entire award for such taking shall be the property of Lessor. 

        21.    Remedies.    If Lessee fails to make any payment of rent or any other sum due under this Lease for five
(5) days or more after receipt by Lessee of written notice from Lessor; or if Lessee breaches any other term of this Lease for thirty (30) days or more after receipt by Lessee of written
notice from Lessor (unless such default is reasonably incapable of cure within thirty (30) days and Lessee commences cure within thirty (30) days and diligently prosecutes the cure to
completion within a reasonable time); or if Lessee's interest herein, or any part thereof, is assigned or transferred, either voluntarily or by operation of law (except as expressly permitted by other
provisions of this Lease); or if Lessee makes a general assignment for the benefit of its creditors; or if this Lease is rejected (1) by a bankruptcy trustee for Lessee, (2) by Lessee as
debtor in possession, or (3) by failure of Lessee as a bankrupt debtor to act timely in assuming or rejecting this Lease; then any of such events shall 

18

 

constitute
an event of default and breach of this Lease by Lessee and Lessor may, at its option, elect the remedies specified in either subparagraph (a) or (b) below. Any such rejection
of this Lease referred to above shall not cause an automatic termination of this Lease. Whenever in this Lease reference is made to a default by Lessee, such reference shall refer to an event of
default ("Event of Default") by Lessee as defined in this Paragraph 21. 

        (a)   Lessor
may repossess the Premises and remove all persons and property therefrom. If Lessor repossesses the Premises because of an Event of Default by Lessee, this Lease
shall terminate and Lessor may recover from Lessee: 

        (1)   the
worth at the time of award of the unpaid rent which had been earned at the time of termination including interest thereon at a rate equal to the Federal discount
rate plus one percent (1%), or the maximum legal rate of interest, whichever is less, from the time of termination until paid; 

        (2)   the
worth at the time of award of the amount by which the unpaid rent which would have been earned after termination until the time of award exceeds the amount of such
rental loss that Lessee proves could have been reasonably avoided, including interest thereon at a rate equal to the Federal discount rate plus one percent (1%) per annum, or the maximum legal rate of
interest, whichever is less, from the time of termination until paid; 

        (3)   the
worth at the time of award of the amount by which the unpaid rent for the balance of the term after the time of award exceeds the amount of such rental loss for the
same period that Lessee proves could be reasonably avoided, discounted at the discount rate published by the Federal Reserve Bank of San Francisco for member banks at the time of award plus one
percent (1%); and 

        (4)   any
other amount necessary to compensate Lessor for all the detriment proximately caused by Lessee's breach or by Lessee's failure to perform its obligations under this
Lease or which in the ordinary course of things would be likely to result therefrom. 

        (b)   If
Lessor does not repossess the Premises, then this Lease shall continue in effect for so long as Lessor does not terminate Lessee's right to possession and Lessor may
enforce all of its rights and remedies under this Lease, including the right to recover the rent and other sums due from Lessee hereunder. For the purposes of this Paragraph 21, the following
do not constitute a repossession of the Premises by Lessor or a termination of the Lease by Lessor: 

        (1)   Acts
of maintenance or preservation by Lessor or efforts by Lessor to relet the Premises; or 

        (2)   The
appointment of a receiver by Lessor to protect Lessor's interests under this Lease. 

        22.    Lessee's Personal Property.    If any personal property of Lessee remains on the Premises after
(1) Lessor terminates this Lease pursuant to Paragraph 20 above following an Event of Default by Lessee, or (2) after the expiration of the Lease term or after the termination of
this Lease pursuant to any other provisions hereof, Lessor shall give written notice thereof to Lessee pursuant to applicable law. Lessor shall thereafter release, store, and dispose of any such
personal property of Lessee in accordance with the provisions of applicable law. 

        23.    Notices.    All notices, statements, demands, requests, or consents given hereunder by either party to the
other shall be in writing and shall be personally delivered or sent by United States mail, 

19

 

registered
or certified, return receipt requested, postage prepaid, and addressed to the parties as follows: 

 

 

			
	Lessor:	 	HDP Associates, LLC

1000 C Commercial Street

San Carlos, California 94070

Attention: Mr. Harold Balzer
	
With a copy to:	
 	
David L. Fletcher, Esq.

2830 North Swan Road, Suite 100

Tucson, Arizona 85712-6301
	
Lessee:	
 	
AnaMax, Inc.

409 Sherman Avenue, Suite A

Palo Alto, California 94306

Attention: David Perry, CEO
	
With a copy to:	
 	
Venture Law Group

2775 Sand Hill Road

Menlo Park, California 94025

Attention: Mark B. Weeks, Esq.

 

 After
the Commencement Date, Lessee's address for notice shall be the Premises. Either party may change its address for notice by giving written notice to the other party of the new address for notice
in accordance with the foregoing provision. Notices shall be deemed given upon receipt or attempted delivery where delivery is not accepted. 

        24.    Estoppel Certificates.    Lessee and Lessor shall within fifteen (15) days following request by the
other party (the "Requesting Party"), execute and deliver to the Requesting Party an Estoppel Certificate
(1) certifying that this Lease has not been modified and certifying that this Lease is in full force and effect, or, if modified, stating the nature of such modification and certifying that
this Lease, as so modified, is in full force and effect; (2) stating the date to which the rent and other charges are paid in advance, if at all; (3) stating the amount of any security
deposit held by Lessor; and (4) acknowledging that there are not, to the responding party's knowledge, any uncured defaults on the part of the Requesting Party hereunder, or if there are
uncured defaults on the part of the Requesting Party, stating the nature of such uncured defaults. 

        25.    Signage.    Lessee shall have the right to erect at Lessee's expense a standard monument sign in an appropriate
location on the Premises designated by Lessor, subject to Lessee obtaining necessary City approvals and subject to the compliance of Lessee's monument sign with applicable City ordinances and
regulations. Lessee shall not place any other signs on or about the Building or the Premises without Lessor's prior written consent. 

20

 

  
        26.    Real Estate Brokers.    Subject to the execution and delivery of this Lease by the parties, Lessor shall pay
a
leasing commission to Cornish & Carey Commercial, the procuring broker, and to CPS, a Commercial Real Estate Company, Inc. ("CPS"), Lessor's agent, pursuant to separate agreements
between Lessor and said brokers. Lessor and Lessee each represents to the other that it has not had any dealings with any real estate broker, finder, or other person with respect to this Lease other
than Cornish & Carey Commercial and CPS, and each party shall indemnify, defend, and hold harmless the other party from all damages, expenses, and liabilities resulting from any claims that may
be asserted against the other party by any broker, finder, or other person with whom the indemnifying party has or purportedly has dealt other than Cornish & Carey Commercial and CPS. 

        27.    Subordination; Attornment.    The Premises are currently free and clear of any mortgage. At least thirty
(30) days prior to placing any mortgage loan on the Premises Lessor shall deliver to Lessee the form of Subordination, Non-Disturbance and Attornment Agreement approved by Lessor's
mortgage lender and Lessor ("Lessor's SNDA"). Lessee shall execute and deliver to Lessor Lessor's SNDA, with such changes as are reasonably requested by Lessee and approved by Lessor and Lessor's
lender. 

        28.    Breach by Lessor.    

        (a)   Lessor
shall not be deemed in breach of this Lease unless Lessor fails within a reasonable time to perform an obligation required to be performed by Lessor pursuant to
this Lease. For purposes of this Paragraph 28, a reasonable time shall in no event be less then thirty (30) days after receipt by Lessor, and by the holders of any mortgage or deed of
trust covering the Premises whose name and address have been furnished to Lessee in writing for such purposes, of written notice specifying wherein such obligation of Lessor has not been performed;
provided, however, that if the nature of Lessor's obligation is such that more than thirty (30) days after such notice are reasonably required for its performance, then Lessor shall not be in
breach of this Lease if performance is commenced within such thirty (30) day period and thereafter diligently pursued to completion. 

        (b)   In
the event of a breach of this Lease by Lessor, unless otherwise set forth herein, Lessee's sole remedy shall be to institute an action against Lessor for damages or
for equitable relief, but Lessee shall not have the right to rent abatement other than as set forth herein, to offset against rent, or to terminate this Lease. Lessee expressly waives the defense of
constructive eviction. If Lessor has not performed any obligation hereunder or any warranty made by Lessor herein proves to be untrue, Lessee shall give Lessor written notice thereof, whereupon Lessee
shall have the right, after giving Lessor a reasonable opportunity to cure in light of the circumstances, to take such corrective action as is reasonably necessary to preserve the integrity of
Lessee's laboratory equipment, research, and experimentation and the health and safety of Lessee's employees and its laboratory animals. Lessor shall reimburse Lessee for any costs or expenses Lessee
incurs in performing such corrective and preventive action, but Lessee shall not have the right to rent abatement, to offset against rent, or to terminate this Lease on account thereof. 

        29.    Approvals.    Notwithstanding anything to the contrary in this Lease, whenever this Lease requires an approval,
consent, designation, determination, or judgment by either Lessor or Lessee, such approval, consent, designation, determination, or judgment (including, without limiting the generality of the
foregoing, those required in connection with assignment and subletting) shall not be unreasonably withheld or delayed and in exercising any right or remedy hereunder, each party shall at all times act
reasonably and in good faith. 

        30.    Lessor's Entry.    Except in the case of an emergency and except for permitted entry if necessary to complete
Lessor's initial tenant improvement work pursuant to Paragraph 12(a) and Paragraph 12(b), or otherwise during Lessee's normal working hours, Lessor and Lessor's agents shall provide
Lessee with at least twenty-four (24) hours' notice prior to entry of the Premises. Such entry by 

21

 

Lessor
and Lessor's agents shall not interfere with Lessee's operations more than reasonably necessary. Lessor and Lessor's agents shall at all times be accompanied by Lessee during any such entry
except in case of emergency. Lessor may enter the Premises without prior notice to Lessee if Lessee has vacated the Premises. 

        31.    Attorneys' Fees.    If any action at law or in equity shall be brought to recover any rent under this Lease, or
for or on account of any breach of or to enforce or interpret any of the provisions of this Lease or for recovery of the possession of the Premises, the prevailing party shall be entitled to recover
from the other party costs of suit and reasonable attorneys' fees, the amount of which shall be fixed by the court and shall be made a part of any judgment rendered. 

        32.    Compliance with CC&Rs.    Lessor warrants that there are no covenants, conditions, and restrictions affecting
the Premises ("CC&Rs") in effect as of the date of this Lease. Lessor agrees that during the term of this Lease Lessor will not without Lessee's prior written consent allow or adopt any CC&Rs that
would have the effect of prohibiting Lessee from undertaking the Permitted Uses or require
Lessee to make alterations or improvements to the Premises to comply with such CC&Rs in order for Lessee to continue to undertake the Permitted Uses. 

        33.    Quiet Possession.    So long as no Event of Default by Lessee exists under this Lease, Lessee shall have quiet
enjoyment and possession of the Premises for the entire term hereof subject to all of the provisions of this Lease. 

        34.    General Provisions.    

        (a)   Nothing
contained in this Lease shall be deemed or construed by the parties hereto or by any third person to create the relationship of principal and agent or of
partnership or of joint venture of any association between Lessor and Lessee, and neither the method of computation of rent nor any other provisions contained in this Lease nor any acts of the parties
hereto shall be deemed to create any relationship between Lessor and Lessee other than the relationship of landlord and tenant. 

        (b)   Each
and all of the provisions of this Lease shall be binding upon and inure to the benefit of the parties hereto, and except as otherwise specifically provided
elsewhere in this Lease, their respective heirs, executors, administrators, successors, and assigns, subject at all times, nevertheless, to all agreements and restrictions contained elsewhere in this
Lease with respect to the assignment, transfer, encumbering, or subletting of all or any part of Lessee's interest in this Lease. 

        (c)   The
captions of the paragraphs of this Lease are for convenience only and shall not be considered or referred to in resolving questions of interpretation or
construction. 

        (d)   This
Lease is and shall be considered to be the only agreement between the parties hereto and their representatives and agents. All negotiations and oral agreements
acceptable to both parties have been merged into and are included herein. There are no other representations or warranties between the parties and all reliance with respect to representations is
solely upon the representations and agreements contained in this instrument. 

        (e)   The
laws of the State of California shall govern the validity, performance, and enforcement of this Lease. Notwithstanding which of the parties may be deemed to have
prepared this Lease, this Lease shall not be interpreted either for or against Lessor or Lessee, but this Lease shall be interpreted in accordance with the general tenor of the language in an effort
to reach an equitable result. 

        (f)    Time
is of the essence with respect to the performance of each of the covenants and agreements contained in this Lease. 

22

 

        (g)   Recourse
by Lessee for breach of this Lease by Lessor shall be expressly limited to the greater of: (1) Lessor's interest in the Premises and the rents, issues
and profits therefrom, or (2) three million dollars ($3,000,000), and in the event of any such breach or default by Lessor Lessee hereby waives the right to proceed against any other assets of
Lessor or against any other assets of any manager or member of Lessor. 

        (h)   Any
provision or provisions of this Lease which shall be found to be invalid, void or illegal by a court of competent jurisdiction, shall in no way affect, impair, or
invalidate any other provisions hereof, and the remaining provisions hereof shall nevertheless remain in full force and effect. 

        (i)    This
Lease may be modified in writing only, signed by the parties in interest at the time of such modification. 

        (j)    Each
party represents to the other that the persons signing this Lease on its behalf are properly authorized to do so. Upon the request of either party, evidence of the
written authority of such persons to sign on behalf of the other party shall be provided to the requesting party hereto either prior to or simultaneously with the return to the requesting party of a
fully executed copy of this Lease. 

        (k)   No
binding agreement between the parties with respect to the Premises shall arise or become effective until this Lease has been duly executed by both Lessee and Lessor
and a fully executed copy of this Lease has been delivered to both Lessee and Lessor. 

        (l)    Lessor
and Lessee acknowledge that the terms and conditions of this Lease constitute confidential information of Lessor and Lessee. Neither party shall disseminate
orally or in written form a copy of this Lease, lease proposals, lease drafts, or other documentation containing the terms, details or conditions contained herein to any third party without
obtaining the prior written consent of the other party, except to the attorneys, accountants, or other authorized business representatives or agents of the parties, or to the extent required to comply
with applicable Laws. 

        (m)  Subject
to the provisions of Paragraph 28, the rights and remedies that either party may have under this Lease or at law or in equity, upon any breach, are
distinct, separate and cumulative and shall not be deemed inconsistent with each other, and no one of them shall be deemed to be exclusive of any other. 

        (n)   Lessor
and Lessee waive any claim for consequential damages which one may have against the other for breach of or failure to perform or observe the requirements and
obligations created by this Lease. 

        (o)   Lessor
and Lessee each agree to and they hereby do waive trial by jury in any action, proceeding or counterclaim brought by either of the parties hereto against the
other on any matters whatsoever arising out of or in any way connected with this Lease, the relationship of Lessor and Lessee, Lessee's use or occupancy of the Premises and/or any claim of injury or
damage, and any statutory remedy. 

        (p)   This
Lease shall not be recorded. 

23

 

        IN
WITNESS WHEREOF, the Lessor and Lessee have duly executed this Lease as of the date first set forth herein. 

 

 

					
	 	 	"Lessor"

  

HDP ASSOCIATES, LLC,

a California limited liability company
	

 	
 	
 By:	
 	
 /s/ HAROLD BALZER

  Manager
	

 	
 	
"Lessee"

  

ANAMAX, INC.,

a Delaware corporation
	

 	
 	
 By:	
 	
 /s/ DAVID PERRY

  Its CEO
	

 	
 	
 By:	
 	
 /s/ LUCY DAY

  Its CFO

 

 24

  LEGAL DESCRIPTION  

 1060 East Meadow Circle

Palo Alto, California  

        REAL PROPERTY located in the City of Palo Alto, County of Santa Clara, State of California, described as follows: 

        Beginning
at the most Southerly corner of that certain parcel of land conveyed to the Deed from L.C. Smith, et ux to Colin M. Peters, et ux, dated January 6, 1958, and recorded
February 6, 1958, in Book 4000 of Official Records, page 714, thence running along the Southwesterly line of said parcel, North 50 degrees 04 minutes 37 seconds West, 195.43 feet, more or less,
to the most Westerly corner thereof, said Westerly corner also being on the Southeasterly right of way line of Barron Dry Creek, thence running along said right of way line of Barron Dry Creek, South
50 degrees 40 minutes 16 seconds West, 275.00 feet, to a point, thence leaving said Barron Dry Creek line above referred to and running South 74 degrees 09 minutes 02 seconds East, 295.17 feet to a
point on the Northwesterly line of East Meadow Circle, thence running along said Northwesterly line on a curve to the right with a radius of 210 feet through a central angle of 24 degrees 04 minutes
25 seconds an arc distance of 88.23 feet, thence North 39 degrees 55 minutes 23 seconds East, 64.11 feet to the point of beginning, being a portion of Lots 140 and 141, C.M. Wooster Subdivision of the
Clarke Ranch, a Map of which was recorded November 11, 1912, in Book O of Maps, at page 16, Santa Clara County Records. 

        APN
No: 127-10-049 

 EXHIBIT "A"  

 COMMENCEMENT MEMORANDUM  

        Date:                        , 2002 

        This
Commencement Memorandum is entered into with respect to the Lease dated October 16, 2002 (the "Lease") between HDP Associates, LLC, a California limited liability company
("Lessor"), and AnaMax, Inc., a Delaware corporation ("Lessee"), of the premises located at 1060 East Meadow Circle, Palo Alto, California (the "Premises"). 

        In
accordance with the Lease, Lessor and Lessee confirm and agree as follows: 

        1.     That
the Premises are accepted by Lessee in the condition required by the Lease on the date hereof; 

        2.     That
Lessee is in possession of the Premises and hereby acknowledges that under the provisions of the Lease the Commencement Date of the term of the Lease is
November 1, 2002 and the Expiration Date of the term of the Lease is October 31, 2005; 

        3.     That
in accordance with the provisions of the Lease, rent commences to accrue on November 1, 2002; and 

        4.     Rent
is due and payable by Lessee in advance on the first (1st) day of each and every month during the term of the Lease. Lessee's rent checks should be
made payable to HDP Associates, LLC and mailed to 1000 C Commercial Street, San Carlos, California 94070. 

AGREED AND ACCEPTED 

 

 

							
	 LESSEE:	 	 LESSOR:
	

ANAMAX, INC.,

a Delaware corporation	
 	
HDP ASSOCIATES, LLC,

a California limited liability company
	
 By:	
 	

  	
 	
 By:	
 	

  
	
Name:	
 	

  	
 	
 Name:	
 	

  
	
Its:	
 	

  	
 	
 Its:	
 	

  

 

  EXHIBIT "B"  

 LESSEE'S HAZARDOUS MATERIALS  

 Chemicals (excluding specialty reagents)  

 

 

								
	 
	 	 
	 	 
	 	 

	Organic Solvents 
	 methanol
	 	N,N-dimethylformamide	 	 	carbon tetrachloride	 	triethylamine
	 ethanol
	 	N-methylpyrrolidone	 	 	chloroform	 	pyridine
	 propanols
	 	tetrahydrofuran	 	 	methylene chloride	 	1,2-dimethoxyethane
	 butanols
	 	dimethyl sulfoxide	 	 	pentane	 	trifluoroacetic acid
	 acetaldehyde
	 	acetonitrile	 	 	hexane	 	 
	 formaldehyde
	 	ethyl acetate	 	 	cyclohexane	 	 
	 acetone
	 	diethyl ether	 	 	toluene	 	 
	 butanone
	 	tert-butyl methyl ether	 	 	1,2-dimethoxyethane	 	 

 

 Inorganic
Acids 

        Sulfuric
acid 

        Hydrochloric
acid 

        Hydrobromic
acid 

        Phosphoric
acid 

        Nitric
acid 

Inorganic
Bases 

        Sodium
hydroxide 

        Potassium
hydroxide 

        Ammonium
hydroxide 

        Others

Carcinogens
(small amounts only) 

Bleach 

 EXHIBIT "C"  

 LESSOR'S FURNITURE, FIXTURES AND EQUIPMENT  

1060
East Meadow Circle

Palo Alto, California 

 

 

				
	 Laboratory Fume Hood
	 	 
	 	 Manufacturer: Kewanunee Scientific Corp.
	 	 
	 	 Model HOS
	 	 
	 	 1.    S/N 77478
	 	 
	 	 2.    S/N 77477
	 	 
	 	 3.    S/N 77480
	 	 
	 	 4.    S/N 77479
	 	 
	 Air Compressor
	 	 
	 	 Tuthill Corporation
	 	 
	 	 Model 65 950 07 50
	 	 
	 	 S/N    22200016052
	 	 
	 Air Compress/Dyer
	 	 
	 	 Kaeser
	 	 
	 	 SK-19
	 	 
	 UPS
	 	 
	 	 Elliott Magnetek Power System
	 	 
	 	 MPSD12
	 	 
	 Furniture
	 	 
	 	 Reception Counter
	 	 
	 	 Wall attached sitting bench
	 	 
	 Outdoor Pots
	 	 
	 	 3 pots front entrance
	 	 
	 	 4 pots back patio area
	 	 

 

  EXHIBIT "D"  

 SCOPE OF LESSEE'S INITIAL IMPROVEMENTS  

        The improvements that AnaMax plans to make to the 1060 East Meadow Circle property are intended to enhance the functionality of the
existing laboratories within the building. 

        The
planned modifications to the facility include: 

	•
	adding fume hoods to two of the existing laboratories   

	•
	installation of sinks in two of the existing laboratories   

	•
	installation of a cage washer, which will require electrical, plumbing and venting modifications to the room where it will
be installed   

	•
	upgrade of the backup power generator, which will require electrical upgrades including dedicated circuits  

	•
	Installation of casework islands within one of the larger laboratories, which will require the running of vacuum, natural
gas and electricity to the bench 

 EXHIBIT "E"  

 AMENDMENT TO LEASE  

1060 East Meadow Circle

Palo Alto, California

        THIS
AMENDMENT TO LEASE (this "Amendment"), dated for reference purposes as of January 21, 2003, is made and entered into by and between HDP ASSOCIATES, LLC, a California limited
liability company ("Lessor"), and ANACOR PHARMACEUTICALS, INC., a Delaware corporation (formerly AnaMax, Inc.) ("Lessee"). 

RECITALS  

        A.    Lessor
and Lessee entered into a Lease dated October 16, 2002 (the "Lease") with regard to the premises commonly known as 1060 East Meadow Circle, Palo Alto,
California. 

        B.    Lessor
and Lessee now wish to enter into this Amendment to amend the Commencement Date and the Expiration Date of the Lease as provided herein. 

AGREEMENT  

        NOW, THEREFORE, in consideration of the mutual covenants contained herein and for other good and valuable consideration, the receipt and sufficiency of which are
hereby acknowledged, the parties agree as follows: 

        1.    Term.    Paragraph 2(a) of the Lease is amended to read as follows: 

        "(a) The
term of the Lease commenced on January 1, 2003 (the "Commencement Date"), and shall expire on December 31, 2005 (the "Expiration Date"), unless sooner
terminated in accordance with the provisions hereof. On or after the Commencement Date Lessor and Lessee shall confirm in writing the Commencement Date and the Expiration Date of the term by executing
and delivering the Commencement Memorandum in the form attached hereto as Exhibit "B" and incorporated by reference herein." 

        The
Commencement Memorandum attached to this Amendment shall replace the Commencement Memorandum attached as Exhibit "B" to the Lease. 

        2.    Continuing Effect.    Except as amended hereby, the Lease shall remain in full force and effect. 

        3.    Counterparts.    This Amendment may be executed in counterparts, each of which shall be deemed an original, but
all of which together shall constitute one and the same instrument. 

        IN
WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed, as of the date first above written. 

 

					
	 	 	LESSOR:
	

 	
 	
HDP ASSOCIATES, LLC,

a California limited liability company
	

 	
 	
 By:	
 	
 /s/ HAROLD BALZER  
	 	 	 	 	

  
	

 	
 	
 Its:	
 	
 VP
	 	 	 	 	

  
	

 	
 	
LESSEE:
	

 	
 	
ANACOR PHARMACEUTICALS, INC.,

a Delaware corporation
	

 	
 	
 By:	
 	
 /s/ LUCY DAY  
	 	 	 	 	

  
	

 	
 	
 Its:	
 	
 CFO
	 	 	 	 	

  
	

 	
 	
 By:	
 	
 /s/ DAVID PERRY  
	 	 	 	 	

  
	

 	
 	
 Its:	
 	
 CEO
	 	 	 	 	

  

 

 

COMMENCEMENT MEMORANDUM

        This
Commencement Memorandum is entered into with respect to the Lease dated October 16, 2002, amended by Amendment to Lease dated January 21,
2003 (the "Lease") between HDP Associates, LLC, a California limited liability company ("Lessor"), and Anacor Pharmaceuticals, Inc., a Delaware corporation (formerly AnaMax, Inc.)
("Lessee"), of the premises located at 1060 East Meadow Circle, Palo Alto, California (the "Premises"). 

        In
accordance with the Lease, Lessor and Lessee confirm and agree as follows: 

        1.     That
the Premises are accepted by Lessee in the condition required by the Lease as of January 1, 2003; 

        2.     That
Lessee is in possession of the Premises and hereby acknowledges that under the provisions of the Lease, as amended by the Amendment to Lease dated January 21,
2003, the Commencement Date of the term of the Lease is January 1, 2003 and the Expiration Date of the term of the Lease is December 31, 2005; 

        3.     That
in accordance with the provisions of the Lease, as amended, rent commenced to accrue on January 1, 2003; and 

        4.     Rent
is due and payable by Lessee in advance on the first (1st) day of each and every month during the term of the Lease. Lessee's rent checks should be
made payable to HDP Associates, LLC and mailed to 1000 C Commercial Street, San Carlos, California 94070. 

AGREED AND ACCEPTED 

 

 

							
	LESSEE:	 	LESSOR:
	

ANACOR PHARMACEUTICALS, INC.,

a Delaware corporation	
 	
HDP ASSOCIATES, LLC,

a California limited liability company
	
 By:	
 	
 /s/ LUCY DAY

 	
 	
 By:	
 	
 /s/ HAROLD BALZER

 
	
 Name:	
 	
 Lucy O. Day

 	
 	
 Name:	
 	
 Harold Balzer

 
	
 Its:	
 	
 CFO

 	
 	
 Its:	
 	
 VP

 
	
 Dated:	
 	
 January 31, 2003

 	
 	
 Dated:	
 	
 January 29th, 2003

 

 

 

 SECOND AMENDMENT TO LEASE

 1060 East Meadow Circle

Palo Alto, California  

        THIS SECOND AMENDMENT TO LEASE (this "Amendment"), dated for reference purposes as of August 1, 2005, is made and entered into
by and between HDP ASSOCIATES, LLC, a California limited liability company ("Lessor"), and ANACOR PHARMACEUTICALS, INC., a Delaware corporation (formerly AnaMax, Inc.) ("Lessee"). 

RECITALS  

        A.    Lessor
and Lessee entered into a Lease dated October 16, 2002, as amended by Amendment to Lease dated as of January 21, 2003 (the "First Amendment") with
regard to the Premises commonly known as 1060 East Meadow Circle, Palo Alto, California. The Lease dated October 16, 2002, as amended by the First Amendment, is referred to herein as the
"Lease." 

        B.    Lessor
and Lessee now wish to enter into this Amendment to amend the Expiration Date of the Lease, to include a grant by Lessor to Lessee of an option to extend the term,
and to include a grant by Lessor to Lessee of the right to terminate the Lease during the option extension period if the option to extend is exercised, subject to the terms and conditions set forth
herein. 

AGREEMENT  

        NOW, THEREFORE, in consideration of the mutual covenants contained herein and for other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the parties agree as follows: 

        1.    Definitions.    All capitalized terms and phrases used but not defined in this Amendment shall have the meanings
given to them in the Lease unless otherwise expressly provided herein. 

        2.    Initial Term.    The first sentence of Paragraph 2(a) of the Lease, as amended by the First Amendment, is
further amended to read as follows: 

        "(a)
The initial term of the Lease commenced on January 1, 2003 (the "Commencement Date"), and shall expire on December 31, 2006 (the "Expiration Date"), unless sooner
terminated in accordance with the provisions hereof." 

        The
Commencement Memorandum attached to this Amendment shall replace the Commencement Memorandum attached to the First Amendment. 

        3.    Monthly Base Rent.    Paragraph 3(a) of the Lease is amended to read as follows: 

        "3.    Monthly Base Rent.    

        (a)   Lessee
shall pay to Lessor during the initial term of this Lease Monthly Base Rent as follows: 

 

 

								
	Period

 
	 	Rent/SF/Mo./NNN 	 	Amount 	 
	 January 1, 2003 - December 31, 2003
	 	$	1.75	 	$	26,775	 
	 January 1, 2004 - December 31, 2004
	 	$	1.80	 	$	27,540	 
	 January 1, 2005 - December 31, 2006
	 	$	1.85	 	$	28,305	 

 

 

Monthly
Base Rent shall be payable on a NNN basis and shall be payable by Lessee to Lessor in accordance with Paragraph 5 hereof." 

 

        4.    Option to Extend.    The Lease is amended by adding thereto a new Paragraph 35, Option to Extend, which
shall to read as follows: 

        "35.    Option to Extend.    

        (a)   Lessor
hereby grants to Lessee one (1) option to extend the term of this Lease for one (1) period of twenty-four (24) calendar months
immediately following the expiration of the initial term. Lessee may exercise the foregoing option to extend by giving written notice of exercise to Lessor at least three (3) months, but not
more than nine (9) months, prior to the expiration of the initial term of this Lease, time being of the essence; provided that if Lessee is currently in a state of uncured default
after the expiration of applicable notice and cure periods (referred to herein as "in default") under this Lease at the time of exercise of the option or at the commencement date of the option
extension period, such notice shall be void and of no force or effect. Such option extension period, if exercised, shall be upon the same terms and conditions as the initial term of this Lease,
including the payment by Lessee of the Operating Expenses of the Premises in accordance with Paragraph 4(b) of the Lease and the real property taxes and assessments in accordance with
Paragraph 4(c) of the Lease, except that (1) the Monthly Base Rent during the option period shall be determined as set forth in Paragraph 35(b) hereof, (2) there shall be
no additional option to extend, and (3) Lessee shall accept the Premises on the commencement date of the option extension period in their then "as is" condition. If Lessee does not exercise the
option in a timely manner the option shall lapse, time being of the essence. 

        (b)   The
initial Monthly Base Rent for the Premises during the option extension period shall be determined pursuant to the provisions of this subparagraph (b) and,
subject to subparagraph (d) below, shall equal one hundred percent (100%) of the then current fair market rental for the Premises as of the commencement date of the option extension period
(hereafter, the "current fair market rental") as determined by agreement between the Lessor and Lessee, if possible, and by the process of appraisal if the parties cannot reach agreement. 

        If
Lessor and Lessee are unable to agree upon the current fair market rental for the Premises, the appraisal shall be performed by one appraiser if the parties are able to agree upon one
appraiser. If the parties are unable to agree upon one appraiser, each party shall appoint an appraiser and the two appraisers shall select a third appraiser. Each appraiser selected shall be a member
of the American Institute of Real Estate Appraisers (AIREA) with at least five (5) years of full-time commercial real estate appraisal experience in the Palo Alto research and
development rental market. 

        If
only one appraiser is selected, that appraiser shall notify the parties in simple letter form of its determination of the current fair market rental for the Premises within fifteen
(15) days following its selection. Said appraisal shall be binding on the parties as the appraised "current fair market rental" for the Premises which shall be based upon the then current
rental paid by tenants for premises in the vicinity of the Premises of similar age, size, quality of construction and specifications, but excluding the value, if any, as of the commencement date of
the option extension period of any improvements constructed in the Premises at Lessee's expense either at the commencement of the initial term or thereafter during the initial term with Lessor's prior
written consent (the "comparable buildings"). If multiple appraisers are selected, each appraiser shall within ten (10) days of being selected make its determination of the current fair market
rental for the Premises in simple letter form. If two (2) or more of the appraisers agree on the rent for the Premises, such agreement shall be binding upon the parties. If multiple appraisers
are selected and two (2) appraisers are unable to agree on the current fair market rental, the current fair market rental for the Premises shall be determined by taking the mean average of the
appraisals; provided, that any high or 

2

 

low
appraisal, differing from the middle appraisal by more than ten percent (10%) of the middle appraisal, shall be disregarded in calculating the average. The appraiser or appraisers may also provide
for an adjustment of the initial current fair market rental during the option extension period if such
adjustment is consistent with the then market practice, subject to the limitation in subparagraph (d) below. 

        If
only one appraiser is selected, then each party shall pay one-half of the fees and expenses of that appraiser. If three appraisers are selected, each party shall bear the
fees and expenses of the appraiser it selects and one-half of the fees and expenses of the third appraiser. 

        (c)   Thereafter,
provided that Lessee has previously given timely notice to Lessor of the exercise by Lessee of the option to extend the term, Lessor and Lessee shall execute
an amendment to this Lease stating that the initial Monthly Base Rent for the Premises during the option extension period shall be equal to the current fair market rental as determined by appraisal,
with any adjustment specified by the appraiser or appraisers, subject to subparagraph (d) below. 

        (d)   Notwithstanding
anything to the contrary contained in subparagraph (b) above, in no event shall the Monthly Base Rent at the commencement of the option extension
period be less than $1.85 per rentable square foot NNN, the Monthly Base Rent in effect immediately prior to the commencement of the option extension period, and in no event shall the Monthly Base
Rent at the commencement of the option extension period, as determined by agreement of the parties or as determined by appraisal if the parties do not agree, increase in total by more than $0.10 per
rentable square foot during the option extension period. 

        (e)   If
Lessee exercises the option to extend, Lessor hereby grants to Lessee the option to terminate this Lease at any time during the option extension period by giving at
least six (6) months' prior written notice of termination to Lessor. If Lessee exercises such termination right, Lessee shall pay all rent due and perform all of Lessee's other obligations
hereunder through the effective date of termination. Monthly Base Rent and Additional Rent shall be prorated as of the effective date of termination." 

        5.    Continuing Effect.    Except as amended hereby, the Lease shall remain in full force and effect. 

        6.    Counterparts.    This Amendment may be executed in counterparts, each of which shall be deemed an original, but
all of which together shall constitute one and the same instrument. 

3

 

        IN
WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed, as of the date first above written. 

 

					
	 	 	LESSOR:
	

 	
 	
HDP ASSOCIATES, LLC,

a California limited liability company
	

 	
 	
 By:	
 	
 /s/ HAROLD BALZER

 
	 	 	 Its:	 	 VP

 
	

 	
 	
LESSEE:
	

 	
 	
ANACOR PHARMACEUTICALS, INC.,

a Delaware corporation
	

 	
 	
 By:	
 	
 /s/ DAVID PERRY

 
	 	 	 Its:	 	 CEO

 
	

 	
 	
 By:	
 	
 /s/ LUCY DAY

 
	 	 	 Its:	 	 CFO

 

 

 4

AMENDED COMMENCEMENT MEMORANDUM  

        This Amended Commencement Memorandum is entered into with respect to the Lease dated October 16, 2002, amended by Amendment to
Lease dated January 21, 2003, and further amended by Second Amendment to Lease dated as of August 1, 2005 (collectively, the "Lease") between HDP Associates, LLC, a California limited
liability company ("Lessor"), and Anacor Pharmaceuticals, Inc., a Delaware corporation (formerly AnaMax, Inc.) ("Lessee"), of the premises located at 1060 East Meadow Circle, Palo Alto,
California (the "Premises"). 

        In
accordance with the Lease, Lessor and Lessee confirm and agree as follows: 

        1.     That
the Premises were accepted by Lessee as of January 1, 2003 in the condition required by the Lease; 

        2.     That
Lessee is in possession of the Premises and hereby acknowledges that under the provisions of the Lease, the Commencement Date of the term of the Lease was
January 1, 2003 and, as specified in the Second Amendment, the Expiration Date of the term of the Lease is December 31, 2006; 

        3.     That
in accordance with the provisions of the Lease, as amended, rent commenced to accrue on January 1, 2003; and 

        4.     Rent
is due and payable by Lessee in advance on the first (1st) day of each and every month during the term of the Lease. Lessee's rent checks should be
made payable to HDP Associates, LLC and mailed to 1000 C Commercial Street, San Carlos, California 94070. 

AGREED AND ACCEPTED 

 

 

											
	 LESSEE:	 	 LESSOR:
	

ANACOR PHARMACEUTICALS, INC.,

a Delaware corporation	
 	
HDP ASSOCIATES, LLC,

a California limited liability company
	 	 	 	 	 	 	 	 	 	 	 
	
 By:	
 	
 	
 	

 	
 	
By:	
 	

 	
 	

 
	 	 	/s/ DAVID PERRY

 	 	 	 	/s/ HAROLD BALZER

 
	Name:	 	 	 	 	 	Name:	 	 	 	 
	 	 	David Perry

 	 	 	 	Harold Balzer

 
	Its:	 	 	 	 	 	Its:	 	 	 	 
	 	 	CEO

 	 	 	 	VP

 
	Dated:	 	 August 22	 	 , 2005	 	 Dated:	 	 August 18	 	 , 2005
	 	 	

  	 	 	 	 	 	

  	 	 

 

 

September 18,
2006 

Ms. Harold
Balzer

HDP Associates, LLC

1000C Commercial Street

San Carlos, CA 94070 

Dear
Hal, 

Per
our discussion, we are providing notice that Anacor Pharmaceuticals, Inc. will accept its option to extend the facility lease at 1060 E. Meadow Circle, Palo Alto for a period of
twenty-four (24) calendar months immediately following the expiration of the initial term pursuant to Section 4(a) of the Second Amendment to Lease dated August 1,
2005, in reference to Section 35. Option to Extend of the Lease dated October 16, 2002. 

Further
to our conversation, we have agreed to modify the period to provide written notice prior to termination of the lease to four (4) months, rather than six (6) months. 

Please
confirm receipt of this notice and agreement with its terms by signing below and returning one copy to my attention. 

We
are looking forward to another lease term with you Hal! 

Kind
regards, 

/s/
LUCY DAY 

Lucy
Day

CFO 

 

 

					
	Accepted:	 	 	 	 
	 	 	/s/ HAL BALZER

  Hal Balzer, HDP Associates	 	 
	Date:	 	9/20/06

 	 	 

 

 

 THIRD AMENDMENT TO LEASE
  1060 East Meadow Circle

Palo Alto, California  

        THIS THIRD AMENDMENT TO LEASE (this "Amendment"), dated for reference purposes as of September 23, 2008, is made and entered
into by and between BALZER FAMILY INVESTMENTS, L.P., a California limited partnership (formerly HDP Associates, LLC) ("Lessor"), and ANACOR PHARMACEUTICALS, INC., a Delaware
corporation (formerly AnaMax, Inc.) ("Lessee"). 

RECITALS

        A.    Lessor
and Lessee entered into a Lease dated October 16, 2002 (the "Original Lease"), as amended by Amendment to Lease dated as of January 21, 2003 (the
"First Amendment"), and as amended by Second Amendment to Lease dated August 1, 2005 (the "Second Amendment") and as amended by that letter agreement dated September 18, 2006 (the
"Letter Agreement"), with regard to the Premises commonly known as 1060 East Meadow Circle, Palo Alto, California. The Original Lease, the First Amendment, the Second Amendment and the Letter
Agreement are referred to collectively herein as the "Lease." 

        B.    Lessor
and Lessee now wish to enter into this Amendment to further amend the Lease to, among other things, amend the Expiration Date of the Lease and include a grant by
Lessor to Lessee of two (2) options to extend the term, all upon and subject to the terms and conditions set forth herein. 

AGREEMENT  

        NOW, THEREFORE, in consideration of the mutual covenants contained herein and for other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the parties agree as follows: 

        1.    Definitions.    All capitalized terms and phrases used but not defined in this Amendment shall have the meanings
given to them in the Lease unless otherwise expressly provided herein. 

        2.    Initial Term.    The first sentence of Paragraph 2(a) of the Lease, as amended by the First Amendment and
the Second Amendment, is further amended to read as follows: 

        "(a) The
initial term of the Lease commenced on January 1, 2003 (the "Commencement Date"), and shall expire on December 31, 2009 (the "Expiration Date"),
unless sooner terminated or extended in accordance with the provisions hereof." 

        The
Amended Commencement Memorandum attached to this Amendment shall replace the Commencement Memorandum attached to the Second Amendment. 

        3.    Monthly Base Rent.    Paragraph 3(a) of the Lease is amended to read as follows: 

        "3.    Monthly Base Rent.    

        (a)   Lessee
shall pay to Lessor during the initial term of this Lease Monthly Base Rent as follows: 

 

 

								
	Period

 
	 	Rent/SF/Mo./NNN 	 	Amount 	 
	 January 1, 2003—December 31, 2003
	 	$	1.75	 	$	26,775	 
	 January 1, 2004—December 31, 2004
	 	$	1.80	 	$	27,540	 
	 January 1, 2005—December 31, 2008
	 	$	1.85	 	$	28,305	 
	 January 1, 2009—December 31, 2009
	 	$	1.95	 	$	29,835	 

 

 
Monthly
Base Rent shall be payable on a NNN basis and shall be payable by Lessee to Lessor in accordance with Paragraph 5 hereof." 

 

        4.    Options to Extend.    The Lease is amended by adding thereto a new Paragraph 35, Options to Extend, which
shall replace in its entirety Paragraph 35, Option to Extend, in Paragraph 4 of the Second Amendment, and shall read as follows: 

        "35.    Option to Extend.    

        (a)   Lessor
hereby grants to Lessee two (2) consecutive options to extend the term of this Lease for a period of twelve (12) calendar months each, with the
first option to extend, if timely exercised, commencing immediately following the Expiration Date of the initial term, and with the second option to extend, if timely exercised, commencing immediately
following the last day of the first option period. Lessee may exercise the foregoing options to extend by giving written notice of exercise to Lessor at least three (3) months, but not more
than nine (9) months, prior to the expiration of the initial term of this Lease, or prior to the expiration of the first option period, as applicable; provided, that if Lessee is currently in a
state of uncured default after the expiration of applicable notice and cure periods (referred to herein as "in default") under this Lease at the time of exercise of an option or at the commencement
date of the applicable option extension period, such notice shall be void and of no force or effect. Each such option extension period, if exercised, shall be upon the same terms and conditions as the
initial term of this Lease, including the payment by Lessee of the Operating Expenses of the Premises in accordance with Paragraph 4(b) of the Lease and the payment by Lessee of the real
property taxes and assessments in accordance with Paragraph 4(c) of the Lease, except that (1) the Monthly Base Rent during each option period is set forth in Paragraph 35(b)
hereof, (2) there shall be no additional option to extend, and (3) Lessee shall accept the Premises on the commencement date of each option extension period in their then "as is"
condition, subject to any continuing repair and maintenance obligations of Lessor. If Lessee does not exercise an option in a timely manner, such option and the succeeding option, if applicable, shall
automatically lapse, time being of the essence. The "lease term," as used in this Lease shall include the initial term and the option period(s), if exercised. 

        (b)   Lessee
shall pay to Lessor during the option periods, if exercised, Monthly Base Rent as follows: 

 

 

								
	Period

 
	 	Rent/SF/Mo./NNN 	 	Amount 	 
	 January 1, 2010—December 31, 2010
	 	$	2.05	 	$	31,365	 
	 January 1, 2011—December 31, 2011
	 	$	2.15	 	$	32,895	 

 

 

        (c)   The
options to extend granted to Lessee by this Paragraph 35 are granted for the personal benefit of Anacor Pharmaceuticals, Inc. ("Anacor") only, and
shall be exercisable only by Anacor or by a "Permitted Affiliate" under Paragraph 16(h). Said options may not be assigned or transferred by Anacor to any assignee or sublessee other than a
Permitted Affiliate." 

        (d)   If
Lessee exercises either or both of the options to extend, Lessor hereby grants to Lessee the option to terminate this Lease at any time during either of the option
extension periods by giving prior written notice of termination to Lessor, provided that the effective date of termination shall be not less than four (4) months after the receipt by Lessor of
the written notice of termination. If Lessee exercises such termination right, Lessee shall pay all rent due and perform all of Lessee's other obligations hereunder through the effective date of
termination. Monthly Base Rent and Additional Rent shall be prorated as of the effective date of Termination." 

2

 

        5.    Address for Notices.    Paragraph 23 of the Lease is hereby amended to change Lessee's address for notice
to: 

 

 

			
	 
	 	 

	"Lessee:	 	Anacor Pharmaceuticals, Inc.

1020 East Meadow Circle,

Palo Alto, California 94303-4230

Attention: CFO
	
With a copy to:	
 	
Cooley Godward Kronish LLP

Five Palo Alto Square

3000 El Camino Real

Palo Alto, CA 94306-2155

Attention: Mark Weeks, Esq.

 

         6..    Furniture, Fixtures and Equipment.    "Exhibit D," Lessor's Furniture, Fixtures and Equipment, of the
Original Lease is hereby amended and replaced in its entirety with Exhibit "D," Lessor's Furniture, Fixtures and Equipment, attached hereto and made a part hereof. 

        7.    Scope of Lessee's Initial Improvements.    Exhibit "E," Scope of Lessee's Initial Improvements, of the Original
Lease is hereby amended and replaced in its entirety with Exhibit "E," Scope of Lessee's Initial Improvements and Additional Modifications, attached hereto and made a part hereof. 

        8.    Continuing Effect.    Except as amended hereby, the Lease shall remain in full force and effect. 

        9.    Counterparts.    This Amendment may be executed in counterparts, each of which shall be deemed an original, but
all of which together shall constitute one and the same instrument. 

        IN
WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed, as of the date first above written. 

 

 

							
	 
	 	 
	 	 
	 	 

	 
	 	LESSOR:
	 
	 	 BALZER FAMILY INVESTMENTS, L.P.

a California limited partnership

	 
	 	 By:
	 	 W.F. BATTON MANAGEMENT COMPANY,

	 
	 	 	 	a California corporation

Its General Partner
	 
	 	 	 	 By:
	 	 /s/ HAROLD BALZER

         Harold Balzer

        President
	 
	 	 LESSEE:

	 
	 	 ANACOR PHARMACEUTICALS, INC.,

a Delaware corporation

	 
	 	 By:
	 	 /s/ DAVID P. PERRY

 
	 
	 	Its:	 	Chief Executive Officer

 
	 
	 	 By:
	 	 /s/ CHRISTINE GRAY-SMITH

 
	 
	 	Its:	 	Chief Financial Officer and Senior Vice President

 

 3

  AMENDED COMMENCEMENT MEMORANDUM  

        This Amended Commencement Memorandum is entered into with respect to the Lease dated October 16, 2002, as amended by Amendment
to Lease dated January 21, 2003 (the "First Amendment"), as further amended by Second Amendment to Lease dated as of August 1, 2005 (the "Second Amendment"), and as further amended by
Third Amendment to Lease dated as of September 23, 2008 (the "Third Amendment') (collectively, the "Lease") between BALZER FAMILY INVESTMENTS, L.P. a California limited partnership
(formerly HDP Associates, LLC) ("Lessor"), and ANACOR PHARMACEUTICALS, INC., a Delaware corporation (formerly AnaMax, Inc.) ("Lessee"), of the premises located at 1060 East Meadow
Circle, Palo Alto, California (the "Premises"). 

        In
accordance with the Lease, Lessor and Lessee confirm and agree as follows: 

        1.     That
the Premises were accepted by Lessee as of January 1, 2003 in the condition required by the Lease; 

        2.     That
Lessee is in possession of the Premises and hereby acknowledges that under the provisions of the Lease, the Commencement Date of the initial term of the Lease was
January 1, 2003 and, as specified in the Third Amendment, the Expiration Date of the initial term of the Lease is December 31, 2009; 

        3.     That
in accordance with the provisions of the Lease, rent commenced to accrue on January 1, 2003; and 

        4.     Rent
is due and payable by Lessee in advance on the first (1st) day of each and every month during the term of the Lease. Lessee's rent checks should be
made payable to Balzer Family Investments L.P. and mailed to 1000 C Commercial Street, San Carlos, California 94070. 

AGREED AND ACCEPTED 

 

 

									
	 
	 	 
	 	 
	 	 
	 	 

	 LESSEE:	 	 LESSOR:
	

ANACOR PHARMACEUTICALS, INC.,

a Delaware corporation	
 	
BALZER FAMILY INVESTMENTS, L.P.,

a California limited partnership
	

 	
 	
 	
 	
By:	
 	
W.F. BATTON MANAGEMENT COMPANY,

a California corporation

Its General Partner
	
 By:	
 	
 

 	
 	

 	
 	

 	
 	

 
	Name:	 	  

 	 	 	 	 	 	 
	Its:	 	  

 	 	 	 	By:	 	    

 
	Dated:                        , 2008	 	 	 	 	 	Harold Balzer

President
	 	 	 	 	 	 	Dated:                        , 2008

 

 

LESSOR'S FURNITURE, FIXTURES AND EQUIPMENT  

1060
East Meadow Circle

Palo Alto, Cailfornia

(Updated September 23, 2008) 

Laboratory
Fume Hood 

Manufacture:
Kewanunee Scientific Corp.

Model HOS

1.    S/N 77478

2.    S/N 77477

3.    S/N 77480

4.    S/N 77479 

Air
Compressor 

Tuthill
Corporation

Model 65 950 07 50

S/N 22200016052 

Air
Compress/Dyer 

Kaeser

SK-19 

Generator 

Model
Olympian D30P4

Engine Model CP50840

S/N      VNPX00301

Volts    208

KVA    35 

Fence
surrounding Generator 

UPS

Elliott
Magnetek Power System

MPSD12

Furniture 

Reception
Counter

Wall attached sitting bench 

Outdoor
Pots 

3
pots front entrance

4 pots back patio area 

 EXHIBIT "D"  

SCOPE OF LESSEE'S INITIAL IMPROVEMENTS

AND

ADDITIONAL MODIFICATIONS
  (Updated September 23, 2008) 

        The
improvements that Anacor made to the 1060 East Meadow Circle property that were intended to enhance the functionality of the existing laboratories within
the building are: 

        Initial
modifications to the facility: 

	•
	adding fume hoods to two of the existing laboratories   

	•
	installation of skins in two of the existing laboratories   

	•
	installation of a cage washer, which required electrical, plumbing and venting modifications to the room where it was
installed   

	•
	upgrade of the backup power generator, which required electrical upgrades including dedicated circuits  

	•
	Installation of casework islands within one of the larger laboratories, which required the running of vacuum, natural gas
and electricity to the bench 

        Additional
modifications to the facility as of September 23, 2008: 

	•
	Autoclave   

	•
	Sterilizer   

	•
	Washer   

	•
	Electric steam generators (2)   

	•
	Walk-in cold box   

	•
	Vacuum system   

	•
	Data cabling   

	•
	Cubicle wiring   

	•
	Heppas in vivarium   

	•
	Water heater*

	*
	Cost
to be shared 50/50 between Lessor and Lessee 

 EXHIBIT "E"  

 

 FOURTH AMENDMENT TO LEASE
  1060 East Meadow Circle

Palo Alto, California  

        THIS FOURTH AMENDMENT TO LEASE (this "Amendment"), effective as of January 1, 2009 and dated for reference purposes as of
March 31, 2009 is made and entered into by and between BALZER FAMILY INVESTMENTS, L.P., a California limited partnership (formerly HDP Associates, LLC) ("Lessor"), and ANACOR
PHARMACEUTICALS, INC., a Delaware corporation (formerly AnaMax, Inc.) ("Lessee"). 

RECITALS  

        A.    Lessor
and Lessee entered into a Lease dated October 16, 2002 (the "Original Lease"), as amended by Amendment to Lease dated as of January 21, 2003 (the
"First Amendment"), as amended by Second Amendment to Lease dated August 1, 2005 (the "Second Amendment"), as amended by a letter agreement dated September 18, 2006 (the "Letter
Agreement"), and as amended by Third Amendment to Lease dated as of September 23, 2008 (the "Third Amendment"), with regard to the Premises commonly known as 1060 East Meadow Circle, Palo Alto,
California. The Original Lease, as amended by the First Amendment, the Second Amendment, the Letter Agreement, and the Third Amendment, are referred to collectively herein as the "Lease." 

        B.    Lessor
and Lessee now wish to enter into this Amendment to amend the Lease further, upon and subject to the terms and conditions set forth herein. 

AGREEMENT  

        NOW, THEREFORE, in consideration of the mutual covenants contained herein and for other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the parties agree as follows: 

        1.    Definitions.    All capitalized terms and phrases used but not defined in this Amendment shall have the meanings
given to them in the Lease unless otherwise expressly provided herein. 

        2.    Additional Rent; Operating Expenses and Taxes.    The first subparagraph of Paragraph 4(e) of the Lease
which reads as follows: 

        "(e) During
December of each calendar year of the term, commencing December 2002, Lessor shall notify Lessee in writing of Lessor's good faith estimate of the Operating
Expenses and Taxes for the following calendar year. Lessor shall include with such notice a description of the Operating Expenses and Taxes. Commencing on January 1, 2003, and on the first
(1st) day of every calendar month of the term thereafter, Lessee shall pay to Lessor monthly in advance, as Additional Rent, one-twelfth (1/12th) of the estimated Operating
Expenses and Taxes for the current calendar year. If during the term it appears to Lessor that the Operating Expenses or Taxes for the current calendar year will vary from Lessor's estimate, Lessor
may, by written notice to Lessee, revise Lessor's estimate Operating Expenses or Taxes for the current calendar year and the Additional Rent and Taxes payments by Lessee for such calendar year shall
thereafter be based upon such revised estimate. Lessor shall furnish to Lessee with such revised estimate written documentation supporting Lessor's revised estimate. The increase in the monthly
installments of Additional Rent and Taxes resulting from Lessor's revised estimate shall not be retroactive, but the Additional Rent and Taxes for such calendar year shall be subject to adjustment
between Lessor and Lessee following the end of each calendar year as provided below." 

2

 

        is
hereby deleted in its entirety and replaced by the following subparagraph: 

        "(e) Monthly
operating Expenses and Taxes actually incurred by Lessor shall be payable by Lessee to Lessor within thirty (30) days after receipt by Lessee of a
monthly invoice from Lessor specifying the nature of the Operating Expenses or Taxes for which payment is requested and the amount payable by Lessee." 

        The
following two subparagraphs of Paragraph 4(e) shall remain in effect. 

        3.    Continuing Effect.    Except as amended hereby, the Lease shall remain in full force and effect. 

        4.    Counterparts.    This Amendment may be executed in counterparts, each of which shall be deemed an original, but
all of which together shall constitute one and the same instrument. 

        IN
WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed, as of January 1, 2009. 

 

 

							
	 
	 	 
	 	 
	 	 

	 
	 	LESSOR:
	 
	 	 BALZER FAMILY INVESTMENTS, L.P.

a California limited partnership

	 
	 	 By:
	 	 W.F. BATTON MANAGEMENT COMPANY,

	 
	 	 	 	a California corporation

Its General Partner
	 
	 	 	 	 By:
	 	 /s/ HAROLD BALZER

         Harold Balzer

        President
	 
	 	 LESSEE:

	 
	 	 ANACOR PHARMACEUTICALS, INC.,

a Delaware corporation

	 
	 	 By:
	 	 /s/ CHRISTINE GRAY-SMITH

 
	 
	 	Its:	 	Chief Financial Officer and Senior Vice President

 
	 
	 	 By:
	 	 /s/ LUCY O. DAY

 
	 
	 	Its:	 	VP Finance

 

 

 3

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