Document:

CONFIDENTIAL TREATMENT REQUESTED:  Certain portions of this document have been omitted pursuant to a request for confidential
treatment and, where applicable, have been marked with an asterisk ("[****]") to denote where omissions have been made.  Note that
sixteen pages of this exhibit contain omitted material pursuant to this request.  The confidential material has been filed
separately with the Securities and Exchange Commission.

                                                                   EXHIBIT 10.1
================================================================================

                                LICENSE AGREEMENT

                    originally dated as of September 23, 1997

                      amended and restated in its entirety
                             as of February 22, 2002

                                 by and between

                          ALLIANCE PHARMACEUTICAL CORP.

                                       and

                           SCHERING AKTIENGESELLSCHAFT

================================================================================

                               TABLE OF CONTENTS

                                                                         Page

                                    ARTICLE I
                                   DEFINITIONS

SECTION 1.01.     Definitions...............................................1

                                   ARTICLE II
                                   DEVELOPMENT

SECTION 2.01.     Development...............................................8
SECTION 2.02.     Drug Approval Applications................................9
SECTION 2.03.     Costs of Development......................................9
SECTION 2.04.     Right to Engage Third Parties.............................9
SECTION 2.05.     Schering Portfolio........................................9

                                   ARTICLE III
                                    LICENSES

SECTION 3.01.     Patent License to Schering................................9
SECTION 3.02.     Patent and Trademark License to Alliance.................10
SECTION 3.03.     Third Party Technology...................................10

                                   ARTICLE IV
                                COMMERCIALIZATION

SECTION 4.01.     Marketing ...............................................11
SECTION 4.02.     Tax Considerations.......................................11

                                    ARTICLE V
                                    ROYALTIES

SECTION 5.01.     Schering Product Royalties...............................12
SECTION 5.02.     Alliance Royalties.......................................14
SECTION 5.03.     Royalty Reports and Payments.............................16
SECTION 5.04.     Payments; Interest.......................................16
SECTION 5.05.     Taxes....................................................16
SECTION 5.06.     Payments to or Reports by Affiliates.....................16
SECTION 5.07.     Payment Currency.........................................17

                                   ARTICLE VI
                             MANUFACTURE AND SUPPLY

SECTION 6.01.     Manufacture and Supply by Alliance.......................17

                                        i

                             CONFIDENTIAL TREATMENT

SECTION 6.02.     Regulatory Approval for Manufacturing....................17
SECTION 6.03.     Step-in Right of Schering................................18
SECTION 6.04.     Technology and Know-How Transfer.........................18
SECTION 6.05.     Regulatory Approval......................................18
SECTION 6.06.     DMF......................................................19
SECTION 6.07.     Acceptance and Pricing...................................19
SECTION 6.08.     Competitive Cost of Goods................................19
SECTION 6.09.     Packaging................................................19

                                   ARTICLE VII
                                 CONFIDENTIALITY

SECTION 7.01.     Confidentiality; Exceptions..............................20
SECTION 7.02.     Authorized Disclosure....................................20
SECTION 7.03.     Survival.................................................21
SECTION 7.04.     Termination of Prior Agreement ..........................21
SECTION 7.05.     Publications ............................................21
SECTION 7.06.     Publicity Review.........................................21

                                  ARTICLE VIII
              OWNERSHIP OF INTELLECTUAL PROPERTY AND PATENT RIGHTS

SECTION 8.01.     Ownership................................................22
SECTION 8.02.     Patent Filings...........................................22
SECTION 8.03.     Third Party Patent Rights................................22
SECTION 8.04.     Enforcement Rights.......................................22
SECTION 8.05.     Defense and Settlement of Third Party Claims.............23
SECTION 8.06.     Patent Expenses..........................................23
SECTION 8.07.     Trademarks...............................................23

                                   ARTICLE IX
                         REPRESENTATIONS AND WARRANTIES

SECTION 9.01.     Representations and Warranties...........................23
SECTION 9.02.     Performance by Affiliates................................24

                                    ARTICLE X
                             INFORMATION AND REPORTS

SECTION 10.01.    Information and Reports During Development and
                  Commercialization .......................................24
SECTION 10.02.    Adverse Drug Experiences.................................25
SECTION 10.03.    Records of Revenues and Expenses.........................25
SECTION 10.04.    Applicability............................................26

                                       ii

                             CONFIDENTIAL TREATMENT

                                   ARTICLE XI
                              TERM AND TERMINATION

SECTION 11.01.    Term.....................................................27
SECTION 11.02.    Termination..............................................27
SECTION 11.03.    Surviving Rights.........................................29

                                   ARTICLE XII
                                 INDEMNIFICATION

SECTION 12.01.    Indemnification .........................................29

                                   ARTICLE XII
                                  MISCELLANEOUS

SECTION 13.01.    Assignment...............................................30
SECTION 13.02.    Retained Rights..........................................30
SECTION 13.03.    Force Majeure............................................30
SECTION 13.04.    Further Actions..........................................31
SECTION 13.05.    No Trademark Rights......................................31
SECTION 13.06.    Notices..................................................31
SECTION 13.07.    Waiver...................................................32
SECTION 13.08.    Severability.............................................32
SECTION 13.09.    Ambiguities..............................................32
SECTION 13.10.    Governing Law............................................32
SECTION 13.11.    Headings.................................................32
SECTION 13.12.    Counterparts.............................................32
SECTION 13.13.    Entire Agreement; Amendments.............................32
SECTION 13.14.    Expenses.................................................33
SECTION 13.15.    Independent Contractors..................................33
SECTION 13.16.    Use of Names.............................................33

EXHIBITS

EXHIBIT A         Determination of Certain Accounting Terms
EXHIBIT B         Alliance Patents
EXHIBIT C         Alliance HI Patents
EXHIBIT D         Schering HI Patents

                                       iii

     LICENSE AGREEMENT (the "AGREEMENT") originally dated as of September 23,
1997 (the "EFFECTIVE DATE"), and amended and restated in its entirety as of
February 22, 2002 (the "RESTATEMENT DATE") by and between ALLIANCE
PHARMACEUTICAL CORP., a New York corporation having its principal place of
business at 3040 Science Park Road, San Diego, California 92121 (hereinafter
referred to as "ALLIANCE") and SCHERING AKTIENGESELLSCHAFT, a German corporation
having its principal place of business at 13342 Berlin, Germany (hereinafter
referred to as "SCHERING"). Alliance and Schering are sometimes referred to
herein individually as a "Party" and collectively as the "Parties."

                              W I T N E S S E T H:

     WHEREAS, Schering is a leading multinational health care company;

     WHEREAS, Alliance is developing through its research and development
activities certain technology for use in ultrasound imaging techniques, and has
the right to grant rights and licenses and/or sublicenses under the Alliance
Patents (hereinafter defined) and Alliance Know-How (hereinafter defined);

     WHEREAS, the Parties entered into a License Agreement dated as of September
23, 1997, as amended by First Amendment to License Agreement dated as of
December 30, 1998, Amendment No. 2 to the License Agreement dated December
20/21, 2000, the side letter of December 20, 2000 and the Waiver dated as of
October 10, 2001 (collectively, the "ORIGINAL LICENSE AGREEMENT"), pursuant to
which, among other things, Alliance granted certain rights and licenses to the
Alliance Patents and Alliance undertook certain action to develop and market
Products and Schering undertook certain action to develop and market Products;

     WHEREAS, the Parties intend to enter into a restructured relationship under
the terms and conditions hereinafter set forth;

     WHEREAS, the Parties intend to record, characterize and report their
activities under this Agreement as separate activities of each of the Parties;

     NOW, THEREFORE, in consideration of the foregoing recitals and the mutual
covenants and agreements contained herein, the Parties hereto, intending to be
legally bound, do hereby agree as follows:

                                    ARTICLE I
                                   DEFINITIONS

     SECTION 1.01. DEFINITIONS. The following terms, when capitalized, shall
have the following meanings (such meanings to be equally applicable to both the
singular and plural forms of the terms defined) as used in this Agreement:

     "AFFILIATE" means any person, corporation, partnership, firm, joint venture
or other entity which, directly or indirectly, through one or more
intermediaries, controls, is controlled by, or is under common control with,
Alliance or Schering, as the case may be. As used in this definition, "control"
means the possession of the power to direct or cause the direction of the
management and policies of an entity, whether through the ownership of the
outstanding voting securities or by contract or otherwise.

     "AF0150" means a white powder [****] which, after reconstitution with
appropriate diluent, forms an aqueous suspension of perfluorohexane/nitrogen-filled
microbubbles with the formulation employed in Phase II Clinical Trials under the United
States IND 49,978.

     "ALLIANCE HI PATENT" means the Patents listed on Exhibit C.

     "ALLIANCE KNOW-HOW" means Information which is within the Control of
Alliance and relates to the research, development, manufacture, use,
importation, sale or offer for sale of the Product. Notwithstanding anything
herein to the contrary, Alliance Know-How shall exclude Alliance Patents.

     "ALLIANCE PATENT" means a Patent which covers the research, development,
manufacture, use, importation, sale or offer for sale of a Product, which Patent
is owned or Controlled by Alliance, including, but not limited to:

     (a)  any patent listed in Exhibit B hereto or added thereto by written
agreement of the Parties during the term of this Agreement;

     (b)  any patent application listed in exhibit B hereto or added thereto by
written agreement of the Parties during the term of this Agreement; and any
division, continuation, or continuation-in-part of any such application; and any
patent which shall issue based on such application, division, continuation or
continuation-in-part;

     (c)  any patent which is a reissue, reexamination or extension of any
patent described in (a) or (b) above;

     (d)  any foreign counterpart patent application or patent corresponding to
any patent identified in (a), (b), or (c), above which is filed or issued in any
country in the Alliance Territory; and

     (e)  any patent or patent application related to or based on any Alliance
Know-How related to the Product or the manufacture thereof developed or acquired
by alliance prior to or during the term of this Agreement and which is necessary
for the use, development, manufacture, market, sale or distribution of any
marketed Product and any division, continuation or continuation-in-part of any
such patent or patent application; and any patent which shall issue based on
such application, division, continuation or continuation-in-part; and any patent
which is a reissue, reexamination or extension of any such patent.

----------
[****] Indicates information that has been omitted because confidential treatment has
  been requested and filed separately with the Securities and Exchange
  Commission.

                                        2
     "ALLIANCE TERRITORY" means (i) the United States of America for the CAD Indication,
(ii) following the Option 1 Effective Date, the United States of America for the CAD Indication
and all of the countries in the world for the TV Indication, (iii) following the Option 2
Effective Date, all of the countries in the world for all indications, excluding however the
TV Indication, and (iv) following the Option 1 Effective Date and the Option 2 Effective Date,
all of the countries of the world for all indications.

     "ALLIANCE PAYMENTS" means all payments made by Alliance to Schering
pursuant to Section 5.02 and all payments made by Alliance to Schering which are
not required to be made pursuant to this Agreement or otherwise.

     "AUDIT DISAGREEMENT" shall have the meaning set forth in Section 10.03(b).

     "BANKRUPTCY EVENT" shall have the meaning set forth in Section 11.02(c).

     "BERLEX" means Berlex Laboratories, Inc., a Delaware corporation.

     "BUSINESS DAY" means a day that is not a Saturday or Sunday in the United
States or a day on which banking institutions chartered by the State of New York
or the United States are required or authorized to be closed.

     "CAD INDICATION" means the indication of an ultrasound agent for intravenous
administration during [****] examination including [****] for the differentiation of
infarcted from ischaemic areas of the myocardium.

     "CLINICAL WORK" means any work related to human trials to assess the
dosing, safety and/or efficacy of a Product and/or to assess a dose and
treatment plan employing such Product, including, but not limited to, Phase III
Clinical Trials and Phase IV Clinical Trials (in the event such Phase IV
Clinical Trials are required by the FDA).

     "COMMERCIALIZATION" and "COMMERCIALIZE" shall refer to all activities
undertaken relating to the pre-marketing, marketing and sale of a Product.

     "COMPETITIVE PRODUCT" means a perfluorocarbon-based product which has
obtained Regulatory Approval for use as an ultrasound contrast agent and such
use is included in the labeling of such product.

     "CONFIDENTIAL INFORMATION" shall have the meaning set forth in
Section 7.01.

     "CONTROL" or "CONTROLLED" shall refer to possession of the ability to grant
a license or sublicense of patent rights, know-how or other intangible rights as
provided for herein without violating the terms of any agreement or other
arrangement with any Third Party.

     "COST OF GOODS " means the cost of Product inventory and other
manufacturing costs incurred with respect to the Product sold. Cost of Goods
shall be calculated in the manner set forth in Exhibit A.

                                        3
     "DEVELOPMENT" and "DEVELOP" shall refer to all activities relating to
obtaining Regulatory Approval of a Product, and all activities relating to
developing the ability to manufacture the same. This includes preclinical
testing, toxicology, formulation, bulk production, fill/finish, manufacturing
process development, manufacturing, quality assurance and quality control
technical support, clinical studies, regulatory affairs and outside counsel
regulatory legal services.

     "DEVELOPMENT EXPENSES" means the expenses incurred in connection with the
Development of a Product. Development Expenses shall include, but are not
limited to, toxicological, pharmacokinetic, metabolic or clinical aspects of a
Product conducted internally or by individual investigators, of design and
manufacture of any required prototype devices, of consultants necessary for the
purpose of obtaining and/or maintaining Regulatory Approval of a Product in the
Alliance Territory, and costs (and related fees) for preparing, submitting,
reviewing or developing data or information for the purpose of submission to a
governmental authority to obtain and/or maintain Regulatory Approval of a
Product in the Alliance Territory.

     "DMF" shall have the meaning set forth in Section 6.06.

     "DOLLARS" means the lawful currency of the United States of America.

     "DOWNPAYMENT" means any lump sum payment to Alliance for any rights to
market or manufacture the Product in the Alliance Territory, specifically
excluding payments (i) for the purchase of equity as Alliance at fair market
value or (ii) based on sales of the Product.

     "DRUG APPROVAL APPLICATION" means an application for Regulatory Approval
required to be approved before commercial sale or use of a Product as a drug in
a regulatory jurisdiction, including, for the purposes of Regulatory Approval in
the United States, a New Drug Application and all supplements filed pursuant to
the requirements of the FDA (including all documents, data and other information
concerning a Product which are necessary for, or included in, FDA approval to
market the Product, as more fully defined in 21 C.F.R. Sections 314.1 et seq.).

     "EFFECTIVE DATE" shall have the meaning set forth in the heading to this
Agreement.

     "EUR" means the lawful currency of the European Monetary Union.

     "EUROPE" means the countries which are members of the European Union as
such membership may change from time to time.

     "FDA" means the United States Food and Drug Administration, or any
successor agency.

     "FIELD" means, at any date of determination, the development, use,
manufacture, distribution, marketing and sale of the Product as an ultrasound
contrast agent in all possible indications, in humans or animals.

                                        4

     "FIRST COMMERCIAL SALE" means the date a Party or its Affiliate or a
sublicensee of a Party first sells commercially, pursuant to a Regulatory
Approval, a Product in any country of the Alliance Territory or the Schering
Territory, as the case may be, provided, however, that where such a first
commercial sale has occurred in a country for which pricing or reimbursement
approval is necessary for widespread sale, then such sales shall not be deemed a
First Commercial Sale until such pricing or reimbursement approval has been
obtained.

     "FIRST PERIOD" means the period commencing on the First Commercial Sale and
ending on the third anniversary of the First Commercial Sale.

     "FULLY LOADED COSTS" means all internal and external costs incurred by
Berlex in the performance of the services described in Section 6.09(a) as
determined by United States Generally Accepted Accounting Principles, applied on
a consistent basis, which shall include without limitation the following costs:
carrying costs of inventories, direct and indirect labor costs, material costs,
and direct and indirect overhead. Fully Loaded Costs of Berlex also shall
include all set up costs necessary for Berlex to perform the functions described
in Section 6.09(a), regardless of depreciation schedules which may have been
established to absorb such costs over a period of time longer than the period
during which Berlex will be performing the described services for Alliance.

     "INFORMATION" means (i) techniques and data within the Field relating to
the Product, including, but not limited to, inventions, practices, methods,
knowledge, know-how, skill, trade secrets, experience, test data including
pharmacological, toxicological, preclinical and clinical test data, regulatory
submissions, adverse reactions, analytical and quality control data, marketing,
pricing, distribution, cost, sales and manufacturing data or descriptions and
(ii) compounds, compositions of matter, assays and biological materials within
the Field relating to the Product.

     "LOSSES" shall have the meaning set forth in Section 12.01(a).

     "LV INDICATION" means the indication of an ultrasound agent for manual
intravenous administration during [****] examination for improved assessment of
global left ventricular function [****].

     "MANUFACTURING PARTY" means the Party who is responsible for the (i)
manufacturing and supply of the Product for use during Development or (ii)
commercial manufacture and supply of the Product.

     "MAXIMUM PAYMENT" shall have the meaning set forth in Section 5.01(a)(ii).

     "MINIMUM DOWNPAYMENT SHARE" means $500,000.

                                        5

     "NET SALES" means the amount invoiced by a Party, its Affiliates or its
sublicensees from sales of the Product to Third Parties, less reasonable and
customary deductions applicable to the Product for (i) transportation charges
and charges such as insurance, relating thereto paid by the selling party; (ii)
sales and excise taxes or customs duties paid by the selling party and any other
governmental charges imposed upon the sale of the Product and paid by the
selling party; (iii) distributors' fees, rebates or allowances actually granted,
allowed or incurred; (iv) quantity discounts, cash discounts or chargebacks
actually granted, allowed or incurred in the ordinary course of business in
connection with the sale of the Product; (v) allowances or credits to customers,
not in excess of the selling price of the Product, on account of governmental
requirements, rejection, outdating, recalls or return of the Product; (vi) costs
of customer programs such as cost effectiveness or patient assistance programs
designed to aid in patient compliance to maintain medication schedules; and
(vii) a one percent (1%) deduction for bad debts. For the purpose of calculating
a Party's Net Sales, the Parties recognize that (a) a Party's customers may
include persons in the chain of commerce who enter into agreements with a Party
as to price even though title to the Product does not pass directly from a Party
to such customers, and even though payment for such Product is not made by such
customers directly to a Party and (b) in such cases chargebacks paid by a Party
to or through a Third Party (such as a wholesaler) can be deducted by a Party
from gross revenue in order to calculate a Party's Net Sales. Any deductions
listed above which involve a payment by a Party shall be taken as a deduction
against aggregate sales for the period in which the payment is made. Sales of
the Product between a Party and its Affiliates or sublicensees solely for
research or clinical testing purposes shall be excluded from the computation of
Net Sales. Net Sales will be accounted for in accordance with international
accounting standards consistently applied.

     "NON-MANUFACTURING PARTY" shall be any Party that is not a Manufacturing
Party.

     "OPTION 1" means the option provided in Section 4.01(b).

     "OPTION 1 EFFECTIVE DATE" means the date which is ninety (90) days
following the date on which Alliance gives Schering written notice of its intent
to exercise Option 1 in accordance with Section 4.01(b) and Section 13.06.

     "OPTION 2" means the option provided in Section 4.01(c).

     "OPTION 2 EFFECTIVE DATE" means the date which is ninety (90) days
following the date on which Alliance gives Schering written notice of its intent
to exercise Option 2 in accordance with Section 4.01(c) and Section 13.06.

     "PATENT" means (i) valid United States and foreign patents,
re-examinations, reissues, renewals, extensions, term restorations, divisionals,
continuations and continuations-in-part thereof, and foreign counterparts
thereof, and (ii) pending applications for United States and foreign patents and
foreign counterparts thereof. "PATENT" also includes a Supplementary Certificate
of Protection of a member state of the European Community and any other similar
protective rights in any other country.

                                        6

     "PATENT EXPENSES" means the fees, expenses and disbursements and outside
counsel fees, and payments to Third Party agents incurred in connection with the
preparation, filing, prosecution and maintenance of Alliance Patents covering
the Product within the Field, including Alliance's costs of patent interference
and opposition proceedings and actions at law and equity for patent infringement
and any sums paid to Third Parties on account of judgments or settlements
arising out of Third Party patent claims (other than such judgments or
settlements resulting in the payment of royalties).

     "PHASE II CLINICAL TRIALS" has the meaning ascribed thereto in 21 C.F.R.
Section 312.21(b), as amended from time to time.

     "PHASE III CLINICAL TRIALS" has the meaning ascribed thereto in 21 C.F.R.
Section 312.21(c), as amended from time to time.

     "PHASE IV CLINICAL TRIALS" means product support clinical trials of a
Product commenced after receipt of Regulatory Approval in the United States for
such Product. These trials shall be considered a part of Clinical Work.

     "PRODUCT" means AF0150 and any drug compounds, drug compositions and
medical devices and systems related to perfluorocarbon containing ultrasound
imaging products and developed by Alliance pursuant to this Agreement (and with
Schering pursuant to the Original License Agreement) which, in the absence of
this Agreement, the use, development, manufacture, marketing, sale or
distribution of which would result in the infringement of one or more claims in
an Alliance Patent or which utilize the Alliance Know-How. For ease of
reference, "Product" is generally expressed in the singular in this Agreement,
but multiple Products may be Developed or marketed hereunder.

     "REGULATORY APPROVAL" means any approvals, product and/or establishment
licenses, registrations or authorizations of any federal, state or local
regulatory agency, department, bureau or other governmental entity, necessary
for the manufacture, use, storage, importation, export, transport or sale of
Product in a regulatory jurisdiction.

     "RESTATEMENT DATE" shall have the meaning set forth in the heading to this
Agreement.

     "ROYALTY AVERAGE" shall have the meaning set forth in Section 5.01(a)(iv).

     "ROYALTY PERCENTAGE" shall have the meaning set forth in Section 5.01.

     "SCHERING TERRITORY" means (i) all of the countries in the world, except the
United States of America for the CAD Indication, (ii) following the Option 1 Effective
Date, all of the countries in the world, except the United States of America for the CAD
Indication, excluding, however, in all cases, the TV Indication, (iii) following the
Option 2 Effective Date, all of the countries in the world for the TV Indication and (iv)
following the Option 1 Effective Date and the Option 2 Effective Date, no country in the world.

                                        7

     "SCHERING HI PATENT" means the patents listed on Exhibit D.

     "SCHERING RECOUPMENT GOAL" means (i) the aggregate amount of Alliance Payments
during the First Period equals or exceeds [****], (ii) the aggregate amount of Alliance
Payments during the First Period and the Second Period equals or exceeds [****] or (iii)
the aggregate amount of Alliance Payments during the First Period, the Second Period and
the Third Period equals or exceeds [****].

     "SECOND PERIOD" means the period commencing on the third anniversary of the
First Commercial Sale and ending on the fourth anniversary of the First
Commercial Sale.

     "SIGNIFICANT CHANGE" means any change requiring prior approval by the FDA
or contemporaneous submission to the FDA of a supplement pursuant to 21 C.F.R.
Sections 314.70(b) or (c), as amended from time to time, if such change is made
subsequent to FDA approval of the Drug Approval Application in the United
States.

     "THIRD PARTY" means any entity other than Alliance or Schering and their
respective Affiliates and sublicensees.

     "THIRD PERIOD" means the period commencing on the fourth anniversary of the
First Commercial Sale and ending on the fifth anniversary of the First
Commercial Sale.

     "TV INDICATION" means the indication of an ultrasound agent for intravenous
administration during [****] examination (or any other ultrasound imaging modes)
for the assessment of tumor vascularity to aid in the [****].

     "WRITTEN DISCLOSURE" shall have the meaning set forth in Section 7.06.

                                   ARTICLE II
                                   DEVELOPMENT

     SECTION 2.01. DEVELOPMENT. Alliance shall use such efforts as it deems
reasonable to execute and substantially perform all Development work for the
Product; provided, however, that (i) Alliance may Develop the Product for the
[****] only after such time as it exercises [****] in accordance with Section
4.01(b) and Section 13.06 and (ii) Alliance may Develop the Product in all the
countries in the world, in addition to the United States of America, for [****],
excluding, however the [****], only after such time as it exercises [****] in accordance
with Section 4.01(c) and Section 13.06.  Until the end of the Third Period, Schering
shall not undertake any steps with a view to Develop the Product in the Schering
Territory without the consent of Alliance.  The Parties agree that Schering [****]
to Develop the Product in the Schering Territory.

                                        8

     SECTION 2.02. DRUG APPROVAL APPLICATIONS.

     (a)  RESPONSIBILITY. Alliance shall be responsible in the Alliance
Territory for preparing and filing Drug Approval Applications and seeking
Regulatory Approvals for the Product, including preparing all reports necessary
as part of a Drug Approval Application. All such Drug Approval Applications
shall be filed in the name of Alliance. Alliance shall be responsible for
prosecuting such Drug Approval Applications. In the event that any regulatory
agency threatens or initiates any action to remove a Product from the market,
Alliance shall notify Schering of such communication within one Business Day of
receipt by Alliance so long as Schering has, or may have, marketing rights under
Article IV.

     (b)  OWNERSHIP. Alliance shall be the legal and beneficial owner of all
Drug Approval Applications and related approvals in the Alliance Territory. If
Schering chooses to market a Product (as co-marketing partner or on its own),
Schering shall have the right, but not the obligation to own the Drug Approval
Application.

     SECTION 2.03. COSTS OF DEVELOPMENT. All Development Expenses incurred by
Alliance for a Product shall be borne by Alliance.

     SECTION 2.04. RIGHT TO ENGAGE THIRD PARTIES. In the course of its business,
Alliance regularly uses Third Parties to perform certain Development activities.
Alliance may continue to do so during the course of this Agreement; provided,
however, that any expenses relating to such Third Party Development will be
incurred and borne by Alliance at its sole expense.

     SECTION 2.05. SCHERING PORTFOLIO. Alliance is aware of the fact that
Schering was, as of the Effective Date, and is, as of the Restatement Date,
manufacturing and selling Competitive Products in certain countries of the
Alliance Territory and will continue to do so in any country of the Alliance
Territory suitable, in Schering's view, for such marketing. Alliance agrees that
nothing in this Agreement is intended to prevent or prevents Schering from such
marketing at its sole discretion.

                                   ARTICLE III
                                    LICENSES

     SECTION 3.01. PATENT LICENSE TO SCHERING.

     (a)  ALLIANCE PATENTS. Alliance grants to Schering an exclusive license
(even as to Alliance) under the Alliance Patents and the Alliance Know-How to
develop, market, sell, and distribute the Product in the Schering Territory.*

     (b)  ALLIANCE HI PATENTS. Alliance grants to Schering a non-exclusive
worldwide license, without a right to sublicense to any other party than
Affiliates, under the

                                        9

Alliance HI Patents to use, develop, manufacture, have manufactured, market,
sell and distribute product for use as an ultrasound contrast agent.

     SECTION 3.02. PATENT AND TRADEMARK LICENSE TO ALLIANCE.

     (a)  SCHERING HI PATENTS. Schering grants to Alliance a non-exclusive
worldwide, royalty-free license, without a right to sublicense, under the
Schering HI Patents to use, develop, manufacture, have manufactured, market,
sell and distribute the Product worldwide for all indications in the Field;
provided, however, that Schering agrees to negotiate in good faith the terms on
which Alliance would be permitted to sublicense Schering HI Patents to contrast
agent manufacturers promptly upon presentation by Alliance of a proposal for
such a sublicense (for the avoidance of doubt, Schering has no obligation to
enter into any such negotiations which regard to a proposed sublicense for the
manufacture of ultrasound equipment).

     (b)  SCHERING TRADEMARK. At Alliance's election, Schering shall grant to
Alliance a non-exclusive royalty-free license in the Alliance Territory, without
a right to sublicense, for the use of the trademark "Imavist" to be used in
connection with the purposes of this Agreement, such license to terminate as of
the first anniversary of the First Commercial Sale.

     SECTION 3.03. THIRD PARTY TECHNOLOGY.

     (a)  EXISTING LICENSES. The licenses granted under Section 3.01 include
sublicenses of Third Party technology existing on the Effective Date and
licensed to Alliance to the extent that such sublicenses can be so granted. Any
royalties payable to Third Parties pertaining to technology discussed in the
previous sentence shall either be paid by Alliance or be offset or deducted from
royalty payments as provided under Section 5.01.

     (b)  SUBJECT TO TERMS. The licenses granted under this Section 3.01, to the
extent they include sublicenses of Third Party Technology, Shall be subject to
the terms and conditions of the license agreement pursuant to which the
sublicense is granted. as of the Effective Date and as of the Restatement Date
hereof there are no such agreements in place.

     (c)  FUTURE THIRD PARTY ROYALTIES.  Alliance shall bear all costs and royalties
in relation to obtaining (whether by license or purchase) Third Party Patents or Third
Party Know-How covering the Product subject to Schering's participation in royalty
payments to Third Parties as set forth in Section 5.01(c).  In the event that Alliance
fails to pay any such costs and/or royalties pursuant to a Third Party license for any
reason, Schering [****] as set forth in Section 5.01.  If there exists a bona fide dispute
between Alliance and such Third Party as to whether any amounts are owed by Alliance,
Schering shall hold the disputed amount of such payment aside pending resolution of
such dispute.

                                       10

                                   ARTICLE IV
                                COMMERCIALIZATION

     SECTION 4.01. MARKETING.

     (a)  ALLIANCE TERRITORY AND SCHERING TERRITORY. Subject to Section 4.01(d),
Alliance shall be the sole marketing Party with respect to the Product in the
Alliance Territory. Subject to Sections 4.01(b) and 4.01(c), Schering shall be
the sole marketing Party with respect to the Product in the Schering Territory;
provided, however, that Schering has no obligation to Develop or Commercialize
the Product in the Schering Territory.

     (b)  OPTION 1. Subject to Section 4.01(d), Alliance shall have the option,
exercisable at the latest by the end of the Third Period upon ninety (90) days
prior written notice to Schering, to become the sole marketing Party with respect
to the Product for the [****].  In the event Alliance exercises such option, Schering
shall not be entitled to any compensation, except as expressly set forth in Section
5.02(b)(iii) or (iv) and Section 5.02(c)(iii) or (iv).

     (c)  OPTION 2.  Subject to Section 4.01(d), Alliance shall have the option,
exercisable at the latest by the end of the Third Period upon ninety (90) days
prior written notice to Schering, to become the sole marketing Party with respect to
the Product [****], excluding however the [****].  In the event Alliance exercises such
option, Schering shall not be entitled to any compensation, except as expressly set forth
in Section 5.02(b)(ii) or (iv) and Section 5.02(c)(ii) or (iv).

     (d)  CO-MARKETING, CO-PROMOTION.  If Schering does not receive the [****] by the
end of the Third Period and the royalty reduction contemplated by Section 5.02(d) shall not
have occurred, Schering shall have the option, exercisable upon ninety (90) days prior
written notice, to [****] in all or part of the Alliance Territory, a [****] in all or
part of the Alliance Territory or a [****].  Such option may be exercised at any time during
the six month period commencing at the end of the Third Period.  If Schering exercises such
option, the Parties agree to negotiate in good faith the terms of any such [****] promptly
following exercises of such option with a view of placing Schering in an economic position
comparable to that contemplated by this Agreement taking into account the obligations undertaken
in such [****]. In no event, however, shall Schering be required to make any initial lump-sum payment.

     SECTION 4.02. TAX CONSIDERATIONS. Either Party may take advantage of tax
considerations which benefit it and not the other Party. In the event that a
Party takes advantage of a tax consideration in connection with a Product which
benefits it and not the other Party, no compensation to the other Party shall be
required; provided, however, that no negative tax implication for the other
Party may be an element of such tax benefit.

                                       11

                                    ARTICLE V
                                    ROYALTIES

     SECTION 5.01. SCHERING PRODUCT ROYALTIES. In further consideration of the
rights and licenses granted to Schering under Section 3.01(a) and Section
3.01(b) of this Agreement, Schering shall pay to Alliance the following
royalties based on the Net Sales of the Product in the Schering Territory (the
"ROYALTY PERCENTAGE"):

     (a)  SALES IN THE SCHERING TERRITORY. With respect to sales of the Product
in the Schering Territory, Schering shall pay royalties in accordance with the
following table:

          (i)   Subject to Section 5.01(b), Schering shall pay to Alliance a
  royalty on Net Sales of the Product in accordance with the following table:

                                                                    Maximum Payment              Royalty Average
             Total Net Sales/Year      Royalty Percentage           (% of Net Sales)            (% of Net Sales)
Category         ($ millions)           (% of Net Sales)         (Section 5.01(a)(ii))        (Section 5.01(a)(iv))
--------         ------------           ----------------         ---------------------        ---------------------

   1.               [****]                     [****]                     [****]

   2.               [****]                     [****]                     [****]                       [****]

   3.               [****]                     [****]                     [****]                       [****]

   4.               [****]                     [****]                     [****]                       [****]

   5.               [****]                     [****]                     [****]                       [****]

          (ii)  In any calendar year the [****] (for Product sold), shall not exceed
the maximum payment percentage ("Maximum Payment") set for in the table above. In the
event payments made during the year are higher than the applicable Maximum Payment
indicated for the category of total annual Net Sales, any such amount exceeding
the Maximum Payment indicated shall be reimbused by Alliance to Schering. Any such
retroactive adjustments made in accordance with this Section 5.01(a) shall be made
after the end of the calendar year for which such adjustment is applicable, and any amount
payable according to such adjustment shall be deducted from future royalty payments by
Schering to Alliance ratably over the next four (4) quarters. Reasonably detailed accounting
records to support such adjustments shall be provided to Alliance within sixty 60) days after
the end of the calendar year.

          (iii) Notwithstanding Section 5.01(a)(i) above, in the event Net Sales
  of Product in the first quarter of any calendar year are [****] of the immediately
preceding calendar year, Net Sales for the [****] shall be totaled and each quarter shall be
deemed to have Net Sales equal to [****] of such total.  Schering shall
  make such adjustments at the end of the first calendar quarter of the year and
  shall deliver any necessary payments (with reasonably detailed records of such
  adjustments) to Alliance within sixty (60) days after the end of the first
  calendar quarter of such year.

                                       12

          (iv)  Notwithstanding Section 5.01(a)(i) above, for purposes of making quarterly
royalty payments only (and not for purposes of actual earned royalty calculations),
royalty payments to Alliance for the [****] of any [****] shall be made at the [****]
(x) the [****] for such category of [****] or (y) the [****] set forth in the table in Section
5.01(a)(i) above (the "Royalty Average") applicable for total Net Sales for the immediately
preceding calendar year. Adjustments from amounts paid as royalties pursuant to this section to
amounts actually earned as royalties shall be made to fourth quarter payments to Alliance
(with reasonably detailed records of such adjustments provided therewith).

     (b)  MINIMUM PAYMENTS. Notwithstanding anything to the contrary in
Section 5.01 (including Maximum Payment limitations), in the first twelve months following the First
Commercial Sale of a Product in the Schering Territory, Alliance shall be paid at least a supply
price corresponding to its Cost of Goods plus [****] for Product sold during such period on a
country-by-country basis, and thereafter at least a supply price corresponding to its Cost of Goods
plus [****] on a country-by-country basis; provided, however, that the Product is supplied by
Alliance.  The supply price of Cost of Goods plus [****] shall be calculated on an aggregate basis.
In the event that the amount equivalent to Alliance's Cost of Goods plus [****], then the parties
will meet to discuss in good faith renegotiation of the terms of payment provided for in this Section
5.01.  If this Section 5.01(b) becomes applicable, then with respect to such product, no other
royalty or manufacturing fee (except for payments for samples and free good discussed below) shall be
payable by Schering to Alliance.  The minimum payments referred to in this Section 5.01(b) shall not
apply to samples of the Product and other free goods which will be purchased by Schering at a price
equal to Alliance's Cost of Goods.

     (c)  THIRD PARTY ROYALTIES. In the event that after the First Commercial
Sale in the Schering Territory, Alliance pays any royalties to Third Parties pursuant to Section 3.03(c)
hereof Schering shall pay to Alliance an amount equal to [****] of such royalties paid by Alliance
to the Third Party based on sales of the Product in the Schering Territory after the First Commercial
Sale in the Schering Territory, provided, however, that Schering's payments to Alliance under this
subsection 5.01(c) shall in no event [****] of Net Sales payable in any applicable calendar quarter.

     (d)  ROYALTY REDUCTION. If the Product is sold in any country in which
Alliance does not have valid patent coverage for the Product which would prevent
the sale of a generic form of the Product, the royalty obligation set forth in
Section 5.01 above with respect to Net Sales attributable to the sale of the
product in such country shall be reduced by [****] of the royalty that would otherwise
be payable with respect to Net Sales attributable to the

                                       13

sale of the Product in such country unless and until Alliance is granted such
valid patent coverage for the Product in such country; provided that this provision shall not
be effective in countries where there is no generic form of the Product being sold.

     (e)  ROYALTY TERM. Except where expressly provided otherwise in this
Agreement, all royalties to a Alliance shall be paid, on a country-by-country
basis, from the date of the First Commercial Sale of a Product in a country in
the Schering Territory until the later of (i) ten (10) years from the First
Commercial Sale in such country or (ii) the last to expire of any valid Alliance
Patents which covers the use or sale of the Product in such country.

     (f)  DISCONTINUANCE. Subject to the provisions of Article XI, Schering may
discontinue Commercialization of a Product at any time.

     (g)  LICENSE FOLLOWING EXPIRATION. Upon expiration of the royalty term for
a Product in the country as described above, Schering shall thereafter have an
exclusive (even as to Alliance), paid-up license to Alliance Know-How to sell,
offer for sale, have sold and import that Product in that country. In such
event, Schering shall retain responsibility for, and indemnify Alliance from,
the payment of all applicable royalties and other obligations owed to a Third
Party with respect to the Product.

     (h)  APPLICABILITY. This Section 5.01 shall be applicable to (i) sales of
the Product for the TV Indication until such time as Alliance becomes the sole
marketing Party with respect to the Product for the TV indication in all the
countries of the world pursuant to Section 4.01(b) and (ii) sales of the Product
in all the countries of the world except the United States of America for the
CAD Indication until such time as Alliance becomes the Sole marketing Party with
respect to the Product in all of the countries of the world for all indications,
excluding however the TV Indication, pursuant to Section 4.01(c).

     SECTION 5.02. ALLIANCE ROYALTIES. In consideration of funds invested by
Schering in the Development of the Product under the Original License Agreement,
Alliance shall make the following payments to Schering.

     (a)  DOWNPAYMENT. Alliance shall pay to Schering a payment equal to [****]
of any Downpayment received by Alliance during the period commencing on the Restatement
Date and ending on the [****] thereof; PROVIDED HOWEVER, that any payment pursuant to
this Section 5.02(a) shall at least equal the Minimum Downpayment Share.

     (B)  ROYALTY WITH MINIMUM DOWNPAYMENT SHARE. In the event that Schering
receives the Minimum Downpayment Share pursuant to Section 5.02(a), Alliance
shall pay to Schering a royalty payment equal to, on a country-by-country basis,
the following:

          (i)  [****] of Net Sales of Product in the Alliance
  Territory in the event that Alliance does not exercise either Option 1 or
  Option 2;

          (ii)  [****] of Net Sales of Product in the event that Alliance exercises
Option 2 but not Option 1;

                                       14

          (iii) [****] of Net Sales of Product in the
  event that Alliance exercises Option 1 but not Option 2; and

          (iv)  [****] of Net Sales of Product in the event
  that Alliance exercises both Option 1 and Option 2.

     (c)  ROYALTY WITHOUT MINIMUM DOWNPAYMENT SHARE. In the event that Schering
does not receive the Minimum Downpayment Share pursuant to Section 5.02(a),
Alliance shall pay to Schering a royalty payment equal to, on a
country-by-country basis, the following:

          (i)   [****] of Net Sales of Product in the
  Alliance Territory in the event that Alliance does not exercise either
  Option 1 or Option 2;

          (ii)  [****] of Net Sales of Product in the
  event that Alliance exercises Option 2 but not Option 1;

          (iii) [****] of Net Sales of Product in the
  event that Alliance exercises Option 1 but not Option 2; and

          (iv)  [****] of Net Sales of Product in the event
  that Alliance exercises both Option 1 and Option 2.

     (d)  ROYALTY REDUCTION.  Any royalty payments payable pursuant to Section
5.02 shall be reduced, on a country-by-country basis, as set forth below:

          (i)   permanently by [****] if Schering introduces a Competitive Product
anywhere in the world prior to the second anniversary of the First Commercial Sale;

          (ii)  permanently by [****] if Schering introduces a Competitive Product
in the Unites States of America following the second anniversary of the First
Commercial Sale in the United States of America;

          (iii) permanently by [****] if Schering introduces a Competitive Product
in the Alliance Territory (other than the Untied States of America) following the second
anniversary of the First Commercial Sale in the Alliance Territory; and

          (iv)  permanently by [****] if Schering introduces a Competitive Product in the
Schering Territory following the second anniversary of the First Commercial Sale in the
Schering Territory.

     (e)  ROYALTY TERM. Except where expressly provided otherwise in this
Agreement, all royalties to Schering shall be paid, on a country-by-country
basis, from the First

                                       15

Commercial Sale of a Product in a country in the Alliance Territory until the
fifth anniversary of such First Commercial Sale in such country.

     (f)  DISCONTINUANCE. Subject to the provisions of Article XI, Alliance may
discontinue Commercialization of a Product at any time.

     SECTION 5.03. ROYALTY REPORTS AND PAYMENTS. Each Party shall make royalty
payments to the other Party within sixty (60) days after the end of each
calendar quarter in which Net Sales by the Party making such royalty payment
occurred. A report summarizing the Net Sales of the Products by each Party
during the relevant quarter on a country-by-country basis shall be delivered to
the other Party within sixty (60) days following the end of each calendar
quarter for which royalties are due.

     SECTION 5.04. PAYMENTS; INTEREST.

     (a)  BUSINESS DAY. Any payments due under this Agreement shall be due on
such date as specified in this Agreement and, in the event such date is a day on
which commercial banks are not authorized to conduct business in either San
Diego, California or Berlin, Germany, then the next succeeding business day, and
shall be made by wire transfer to a designated bank account of the receiving
Party.

     (b)  INTEREST. Any failure by a Party to make a payment within five days
after the date when due shall obligate such Party to pay interest during the
period commencing on the due date and ending on the payment date to the
receiving Party at a rate per annum equal to the [****] as quoted by Bank of America
on REUTERS screen {USPRIME 1} as of the date such payment is due and, in the event
such a rate is not quoted on such date then on the immediately preceding date such
rate is quoted. The interest rate shall be adjusted whenever there is a change in the
[****] quoted by Bank of America on REUTERS screen {USPRIME 1}. Interest shall be
compounded annually in arrears. Such interest shall be due and payable upon the payment
of the underlying principal otherwise due and payable.

     SECTION 5.05. TAXES. The Party receiving royalties shall pay any and all
taxes levied on account of royalties it receives under this Agreement. If laws
or regulations require that taxes be withheld, the selling Party will (i) deduct
those taxes from the remittable royalty, (ii) timely pay the taxes to the proper
taxing authority, and (iii) send proof of payment to the other Party within
thirty (30) days of receipt of confirmation of payment from the relevant taxing
authority. The selling Party agrees to take all lawful and reasonable efforts to
minimize such taxes to the other Party.

     SECTION 5.06. PAYMENTS TO OR REPORTS BY AFFILIATES. Any payment required
under any provision of this Agreement to be made to either Party or any report
required to be made by any Party shall be made to or by an Affiliate of that
Party if designated by that Party as the appropriate recipient or reporting
entity without relieving such party from responsibility for such payment or
report.

                                       16

     SECTION 5.07. PAYMENT CURRENCY. Payments by under this Agreement shall be
paid in Dollars by wire transfer of immediately available funds to an account at
a commercial bank designated by Alliance or Schering pursuant to this Article V
at least ten (10) business days before payment is due. Where payments are based
on Net Sales in countries other than the United States, the amount of such Net
Sales expressed in the currency of each country shall be converted into Dollars
by Schering or Alliance, respectively, as set forth below:

          (i)   SCHERING: The calculation of royalty payments within Schering is
  based upon EUR. Therefore, where payments are based on Net Sales in countries
  other than the member states of the European Monetary Union, the amount of
  such Net Sales expressed in the currency of each country shall be converted
  into EUR at the Euro Foreign Exchange Reference Rates published by the
  European Central Bank in Frankfurt / Main, Germany on the last Business Day of
  the applicable calendar quarter. The resulting EUR amount will be converted
  into Dollars again at the Euro Foreign Exchange Reference Rates published by
  the European Central Bank in Frankfurt / Main, Germany on the last Business
  Day of the applicable calendar quarter. These Euro Foreign Exchange Reference
  Rates are, as of the effective date, published on REUTERS screen {ECB37}. If
  no Euro Foreign Exchange Reference Rate is determined for the relevant
  currency the parties shall agree upon another reference rate.

          (ii)  ALLIANCE: The calculation of royalty payments within Alliance is
  based upon Dollars. Therefore, where payments are based on Net Sales in
  countries other than the United States, the amount of such Net Sales expressed
  in the currency of each country shall be converted into Dollars at the 12 p.m.
  Buying Rates published by the Federal Reserve Bank of New York on REUTERS
  screen  {FEDSPOT} on the last business Day of the applicable calendar
  quarter. if no 12 p.m. Buying Rate is determined for the relevant currency the
  parties shall agree upon another reference rate.

                                   ARTICLE VI
                             MANUFACTURE AND SUPPLY

     SECTION 6.01. MANUFACTURE AND SUPPLY BY ALLIANCE. Alliance shall use
commercially reasonable efforts, subject to the greater of the capacity of
Alliance's San Diego manufacturing facility as of the date hereof or the date of
filing of the Drug Approval Application for the United States, to manufacture,
or arrange for manufacture of Schering's, or its Affiliates' requirements of at
least [****]          of the Product per calendar year ("the Minimum Capacity") for
supply to Schering for the Commercialization of the Product in each applicable
country in the Schering Territory and/or the Commercialization of the Product in
the Alliance Territory after Schering has exercised its option according to
Section 4.01(d). Schering hereby agrees to purchase all of its requirements of
the Product from Alliance.

     SECTION 6.02. MANUFACTURING AND SUPPLY AGREEMENT. As soon as it is clear
that Schering will Commercialize the Product, the Parties will negotiate and
execute in good faith a manufacturing and supply agreement which shall at least
contain, but shall not be limited

                                       17

to, terms on the following topics: orders and forecasts, quality testing and
quality control, GMP and regulatory compliance, change management, record
keeping, audits and inspection rights, delivery/acceptance/rejections of
products, shipment, failure of delivery, product complaints and recalls,
technology transfer in case of failure to supply, pharmaceutical
responsibilities, joint manufacturing committee, term and termination, and a
detailed quality assurance agreement as appendix.

     SECTION 6.03. STEP-IN RIGHT OF SCHERING. Notwithstanding Section 6.01
Schering shall have the right, but not the obligation, to become the
manufacturer for its own requirements of the Product

     (a)  if Alliance is not capable of manufacturing, or arranging for
manufacture all of Schering's, or its Affiliates' requirements up to the Minimum
Capacity, Alliance shall notify Schering sufficiently in advance, but at least
six (6) months prior to the then required transfer of the manufacturing process;

     (b)  upon two (2) years advanced written notice to Alliance in accordance
with Section 13.06 that Schering intends to become a manufacturing party for
Schering's, or its Affiliates' requirements of the Product.

     SECTION 6.04. TECHNOLOGY AND KNOW-HOW TRANSFER.

     (a)  In the event Schering becomes a manufacturer of the Product pursuant
to Section 6.03 or Section 6.08, Alliance will transfer to Schering all relevant
and necessary technology and know-how related to the manufacturing process,
including but not limited to manufacturing descriptions, master batch records,
executed batch records, release specifications and release testing methods (for
active pharmaceutical ingredients, other raw materials, packaging material and
finished products), in process testing methods, in process specifications,
annual product reviews, validation reports, techniques and formulae, equipment
descriptions in order to enable Schering to manufacture the Product for its, or
its Affiliates' requirements of Product.

     (b)  Such transfer shall be done in close coordination with Schering as
promptly as possible after receipt of Schering's notice that Schering wants to
become a manufacturing party for the Product.

     (c)  Alliance will allow and enable Schering to contact the relevant
personnel at Alliance to facilitate the transfer.

     (d)  Alliance will, at Schering's cost, give the necessary support and
advice to Schering during the transfer and with regard to registration and
regulatory issues linked to such transfer of Product production to a new
production site.

     SECTION 6.05. REGULATORY APPROVAL FOR MANUFACTURING. Alliance shall use
commercially reasonable efforts to make necessary filings to obtain, or to cause
a Third Party manufacturer to make necessary filings to obtain, Regulatory
Approval for the manufacture of

                                       18

the Product as part of the approval of a Drug Approval Application for each
Product. Alliance shall notify Schering without delay of all changes to the
process for the manufacture of the Product or its drug substance, whether such
changes are Significant Changes or not.

     SECTION 6.06. DMF. Alliance shall be responsible for all testing and
document generation (including without limitation all facilities information and
related documentation; chemistry, manufacturing, and control information;
regulatory methods and controls; assays and reference standards) necessary for
filing a drug master file ("DMF") with the FDA for the production of the drug
substance from which each Product is formulated. Alliance shall also be
responsible for filing such DMF with the FDA for the production of the drug
substance from which each Product is formulated.

     SECTION 6.07. ACCEPTANCE AND PRICING. With respect to Product that Alliance
supplies to Schering for sale,Alliance shall be entitled to reimbursement by Schering
of [****]. Schering shall have the right to test Products upon delivery at its expense
for compliance with specifications and legal and regulatory requirements; provided, however,
that Schering shall be invoiced and shall pay a supply price equal to Alliance's Cost of Goods
plus [****] for Products shipped during the first [****] after the First Commercial Sale, and
plus [****] thereafter to cover the minimum payments to the extent provided for in Section
5.01(b); provided however that

     (i)  the supply price to be paid by Schering to Alliance shall not be less favourable than
that supply price paid to Alliance for Product sold by any other third party, and

     (ii) the Parties shall meet and negotiate in good faith if the Cost of Goods in
average increase within a period of 12 months of more than [****].

     SECTION 6.08. COMPETITIVE COST OF GOODS. If Schering is able to manufacture
or to have manufactured the Product for its or its Affiliates' requirements at Cost of
Goods that are lower than Alliance's Cost of Goods by more than [****], Schering shall
have the right to take over manufacturing, unless Alliance is reducing its Cost of Goods
accordingly.

     SECTION 6.09. PACKAGING

     (a)  BERLEX. Schering shall cause Berlex to perform or have performed those
services relating to the packaging of the Product for the United States market
until such time as Alliance or a designee of Alliance obtains Regulatory
Approval to perform such services, but not to exceed one (1) year. Alliance
shall use diligent efforts to obtain such Regulatory Approval as promptly as
possible. As compensation for such services by Berlex, or under Berlex's
direction, Alliance will pay [****] of Berlex. In the event that Berlex performs the
services described above for Alliance for more than one (1) year, then for such additional
period, Alliance will pay [****] of Berlex.

                                       19

     (b)  SCHERING PACKAGING. Products manufactured by Alliance shall be
supplied to Schering in packaged form as Schering reasonably directs after
consultation with Alliance. Packaging and labeling costs incurred by Alliance
and/or Schering shall be included in Costs of Goods Sold.

                                   ARTICLE VII
                                 CONFIDENTIALITY

     SECTION 7.01. CONFIDENTIALITY; EXCEPTIONS. Except to the extent expressly
authorized by this Agreement or otherwise agreed in writing, the Parties agree
that the receiving Party shall keep confidential and shall not publish or
otherwise disclose or use for any purpose other than as provided for in this
Agreement any Information and other information and materials furnished to it by
the other Party pursuant to this Agreement or any Information developed during
the course of the collaboration hereunder, or any provisions of this Agreement
that are the subject of an effective order of the United States Securities
Exchange Commission granting confidential treatment pursuant to the United
States Securities Act of 1934, as amended (collectively, "CONFIDENTIAL
INFORMATION"), except to the extent that it can be established by the receiving
Party that such Confidential Information:

     (a)  was already known to the receiving Party, other than under an
obligation of confidentiality, at the time of disclosure by the other Party;

     (b)  was generally available to the public or otherwise part of the public
domain at the time of its disclosure to the receiving Party;

     (c)  became generally available to the public or otherwise part of the
public domain after its disclosure and other than through any act or omission of
the receiving Party in breach of this Agreement;

     (d)  was disclosed to the receiving Party, other than under an obligation
of confidentiality, by a Third Party who had no obligation to the disclosing
Party not to disclose such information to others; or

     (e)  was independently discovered and/or developed by the receiving Party
as documented in its corporate records.

     SECTION 7.02. AUTHORIZED DISCLOSURE. Each Party may disclose Confidential
Information hereunder to the extent such disclosure is reasonably necessary in
filing or prosecuting patent applications, prosecuting or defending litigation,
filing or updating any Drug Approval Application, complying with applicable
governmental regulations or conducting pre-clinical or clinical trials,
provided that if a Party is required by law or regulation to make any such
disclosures of the other Party's Confidential Information it will, except where
impracticable for necessary disclosures, for example in the event of medical
emergency, give reasonable advance notice to the other Party of such disclosure
requirement and, except to the extent inappropriate in the case of patent
applications, will use its reasonable efforts to secure confidential treatment
of such Confidential Information required to be disclosed. In addition,

                                       20

and with prior notice to the other Party of each Third Party with whom a
confidential disclosure agreement is being entered into, each Party shall be
entitled to disclose, under a binder of confidentiality, Confidential
Information to any Third Party for the purpose of carrying out the purposes of
this Agreement. Nothing in this Article VII shall restrict any Party from using
for any purpose any Confidential Information independently developed by it
during the course of the collaboration hereunder, or from using Confidential
Information that is specifically derived from pre-clinical or clinical trials to
carry out Regulatory Approval, marketing, sales or professional services support
functions as is customary in the pharmaceutical industry.

     SECTION 7.03. SURVIVAL. This Article VII shall survive the termination or
expiration of this Agreement.

     SECTION 7.04. TERMINATION OF PRIOR AGREEMENT. This Agreement supersedes
the Secrecy Agreement between Alliance and Schering dated as of January 14,
1997. All Information exchanged between the Parties under that Agreement shall
be deemed Confidential Information and shall be subject to the terms of this
Article VII.

     SECTION 7.05. PUBLICATIONS. Prior to the launch of a Product, Alliance will
determine the overall strategy for publication in support of such Product.
Notwithstanding any term of Section 7.06 below, the Parties recognize the need
for scientific publications pertaining to development of the Product and the
Parties will cooperate to provide for such publications; provided, however, that
the right of any Party to withhold or delay consent to publish or delay
publication shall be subject to any contractual publication rights of Third
Parties involved in research or clinical trials for the Product. The Parties
will use reasonable efforts to obtain the voluntary consent of any Third Party
granted publication rights related to the Product prior to the Effective Date to
comply with reasonable notice and timing requests and will promptly review any
publications delivered for review.

     SECTION 7.06. PUBLICITY REVIEW. Subject to the further provisions of this
Section 7.06 and Section 10.04, no Party shall originate any written publicity,
news release, or other announcement or statement relating to this Agreement or
to performance hereunder or the existence of an arrangement between the Parties
(collectively, "WRITTEN DISCLOSURE"), without the prior prompt review and
written approval of the other, which approval shall not be unreasonably withheld
or delayed. Notwithstanding the foregoing provisions of this Section 7.06, any
Party may make any public Written Disclosure it believes in good faith based
upon the advice of counsel is required by applicable law or any listing or
trading agreement concerning its publicly traded securities, provided that prior
to making such Written Disclosure, the disclosing Party shall provide the other
Party with a copy of the materials proposed to be disclosed and provide the
receiving Party with an opportunity to promptly review the proposed Written
Disclosure. To the extent that the receiving Party reasonably requests that any
information in the materials proposed to be disclosed be deleted, the disclosing
Party shall request confidential treatment of such information pursuant to Rule
406 of the United States Securities Act of 1933 or Rule 26b-2 of the United
States Securities Exchange Act of 1934, as applicable (or any other applicable
regulation relating to the confidential treatment of information), so that there
be omitted from the materials that are publicly filed any information that the
receiving Party reasonably requests to

                                       21

be deleted. The terms of this Agreement may also be disclosed to (i) government
agencies where required by law, or (ii) Third Parties with the prior written
consent of the other Party, which consent shall not be unreasonably withheld or
delayed, so long as such disclosure is made under a binder of confidentiality
and so long as highly sensitive terms and conditions such as financial terms are
extracted from the Agreement or not disclosed upon the request of the other
Party. All Written Disclosures shall be factual and as brief as is reasonable
under the circumstances. Upon request by either Party, the Parties agree to
prepare a mutually agreed press release and question and answer document with
respect to this Agreement. Each Party agrees that it will use reasonable efforts
to cause all Written Disclosures and oral statements relating hereto to be
consistent with the answers specified in such question and answer document.

                                  ARTICLE VIII
              OWNERSHIP OF INTELLECTUAL PROPERTY AND PATENT RIGHTS

     SECTION 8.01. OWNERSHIP. Each Party shall solely own, and it alone shall
have the right to apply for, Patents within and outside of the United States for
any inventions made solely by that Party's employees or consultants in the
course of performing work under this Agreement.

     SECTION 8.02. PATENT FILINGS. Each Party, at its sole discretion and
responsibility, shall prepare, file, prosecute and maintain Patents to cover
discoveries and inventions made solely by its own employees or consultants.

     SECTION 8.03. THIRD PARTY PATENT RIGHTS. Each Party agrees to bring to
the attention of the other Party any Third Party Patent it discovers, or has
discovered, and which relates to the subject matter of this Agreement.

     SECTION 8.04. ENFORCEMENT RIGHTS.

     (a)  NOTIFICATION OF INFRINGEMENT. If either Party learns of any
infringement or threatened infringement by a Third Party of the Alliance
Patents, such Party shall promptly notify the other Party and shall provide such
other Party with all available evidence of such infringement.

     (b)  ENFORCEMENT IN THE TERRITORY. Alliance shall have the right, but not
the obligation, to institute, prosecute and control at its own expense any
action or proceeding with respect to infringement of any Alliance Patents
covering the manufacture, use, importation, sale or offer for sale of the
product being developed or marketed by counsel of its own choice. Where possible
with regard to manpower and time, Schering upon Alliance's request and at
Alliance's costs, shall give documentary support and reasonable assistance in
such proceedings. Any damages or other monetary awards recovered pursuant to
this Section 8.04(b) shall be for the account of Alliance. If Alliance fails or
does not want to bring an action or proceeding or otherwise take appropriate
action to abate such infringement within a period of one hundred eighty (180)
days of notice by Schering to Alliance requesting such action, Schering shall
have the right, but not the obligation, to institute, prosecute and control at
its own expense any such

                                       22

action or proceeding with respect to infringement of any Alliance patents. Any damages
or other monetary awards recovered by Schering in such case shall be for the account
of Schering.

     (c)  SETTLEMENT WITH A THIRD PARTY. Alliance shall also have the right to
control settlement of such action; provided, however, that no settlement shall
be entered into without the written consent of the Schering (which consent shall
not be unreasonably withheld) if such settlement would materially and adversely
affect the interests of Schering.

     SECTION 8.05. DEFENSE AND SETTLEMENT OF THIRD PARTY CLAIMS. If a Third
Party asserts that a patent, trademark or other intangible right owned by it is
infringed by any Product, Alliance will be solely responsible for defending
against any such assertions at its cost and expense (subject to the provisions
of Section 8.04(b)). Any determination regarding the necessity to license or
otherwise obtain rights under or invalidate certain Third Party Patents covering
the Product shall be made by Alliance; provided, however, that no settlement may
be entered into without the written consent of Schering (which shall not be
unreasonably withheld) if such settlement would materially and adversely affect
the interests of Schering. The costs of any such settlement (including, without
limitation, damages, expense reimbursements, compliance, future royalties or other
amounts) shall be paid exclusively by Alliance; provided, however, that with respect
to future royalties only, Section 5.01(c) shall apply.

     SECTION 8.06. PATENT EXPENSES. All worldwide Patent Expenses shall be
borne by Alliance, subject to the terms of this Agreement.

     SECTION 8.07. TRADEMARKS.

     (a)  SCHERING. Schering shall be responsible for the selection,
registration and maintenance of all trademarks which it employs in connection
with the Product and shall own and control such trademarks (and pay any costs in
connection therewith). Alliance recognizes the exclusive ownership by Schering
of any proprietary Schering name, logotype or trademark furnished by Schering
(including Schering's Affiliates) for use in connection with the Product.
Alliance shall not, either while this Agreement is in effect, or at any time
thereafter, register, use or attempt to obtain any right in or to any such name,
logotype or trademark or in and to any name, logotype or trademark confusingly
similar thereto.

     (b)  ALLIANCE.  Schering hereby reconveys to Alliance all rights to the
trademark for "Imagent" granted pursuant to the Original License Agreement.

                                       8

                                   ARTICLE IX
                         REPRESENTATIONS AND WARRANTIES

     SECTION 9.01. REPRESENTATIONS AND WARRANTIES.

     (a)  Each of the Parties hereby represents and warrants to the other Party
as follows:

                                       23

          (i)   This Agreement is a legal and valid obligation binding upon such
  Party and enforceable in accordance with its terms. The execution, delivery
  and performance of the Agreement by such Party does not conflict with any
  agreement, instrument or understanding, oral or written, to which it is a
  party or by which it is bound, nor violate any law or regulation of any court,
  governmental body or administrative or other agency having jurisdiction over
  it.

          (ii)  Alliance has not, and during the term of the Agreement neither
  Party will, (x) grant any right to any Third Party relating to the Alliance
  Patents and to Alliance Know-How in the Field which would conflict with the
  rights granted to either Party hereunder, and (y) to the best of its knowledge
  neither party is employing (as an employee or consultant), nor will either
  Party employ during the term of this Agreement, any person that has been
  debarred by the FDA.

          (iii) To the best of its knowledge Alliance is not obligated under any
  agreement as of the Effective Date and the Restatement Date to pay any Third
  Party royalties with respect to the Product. As of the Effective Date and the
  Restatement Date there are no such agreements in place.

     (b)  Alliance hereby represents and warrants to Schering as follows:

          (i)   It has given Schering access to all its pre-clinical and
  clinical records regarding the Product in existence as of the Effective Date
  and the Restatement Date.

          (ii)  As of the Effective Date and the Restatement Date, except as it
  may have previously disclosed to Schering in writing or otherwise, it has not
  received any notices of infringement or any written communications relating in
  any way to a possible infringement with respect to any Alliance Patent.

     SECTION 9.02. PERFORMANCE BY AFFILIATES. The Parties recognize that each
Party may perform some or all of its obligations under this Agreement through
Affiliates; provided, however, that each Party shall remain responsible for and
be a guarantor of the performance by its Affiliates and shall cause its
Affiliates to comply with the provisions of this Agreement in connection with
such performance.

                                    ARTICLE X
                             INFORMATION AND REPORTS

     SECTION 10.01. INFORMATION AND REPORTS DURING DEVELOPMENT AND
COMMERCIALIZATION. Schering and Alliance will disclose and make available
(subject to any confidentiality agreements or requirements of law) to each other
without charge all preclinical, clinical, regulatory, pricing, sales and other
Information, including copies of all preclinical and clinical reports, known by
Schering or Alliance directly concerning the Product within the Field at any
time during the term of this Agreement. Each Party shall own and maintain its
own database of clinical trial data accumulated from all clinical trials of the
Product for which it was

                                       24

responsible and of adverse drug event information for the Product. At the option
of the requesting Party, such data shall be provided in a computer readable
format by the providing Party, to the extent available, which shall also assist
in the transfer and validation of such data to the receiving Party. Without
limitation of the foregoing, each Party shall supply to the other the
Information required by the other Party and requested by it (either as a routine
practice or as a specific request) for purposes of compliance with regulatory
requirements.

     SECTION 10.02. ADVERSE DRUG EXPERIENCES.

     (a)  Alliance agrees to provide to Schering for initial and/or periodic
submission to government agencies significant information on the Product from
preclinical laboratory, animal toxicology and pharmacology studies, as well as
adverse drug experience reports from clinical trials and commercial experiences
with the Product;

     (b)  Each party agrees to, in connection with investigational Products,
report to the other party as soon as possible (and, in any event, within three
(3) days) the receipt of a report of any unexpected or serious experience, if
required for the other Party to comply with regulatory requirements;

     (c)  Each Party agrees to, in connection with marketed Products, report to
the other Party within three (3) business days of the receipt of a report of any
adverse experience that is serious and unexpected or sooner if required for the
other Party to comply with regulatory requirements. Serious adverse experience
means any experience that suggests a significant hazard, contraindication, side
effect or precaution, or any experience that is fatal or life threatening, is
permanently disabling, requires or prolongs inpatient hospitalization, or is a
congenital anomaly, cancer, or overdose. An unexpected adverse experience is one
not identified in nature, specificity, severity or frequency in the current
investigator brochure or the U.S. labeling for the drug; and

     (d)  If requested by Schering, Alliance agrees to enter into a standard
operating procedure by and between the Parties to govern the exchange of
information relating to adverse drug experiences and product quality.

     SECTION 10.03. RECORDS OF REVENUES AND EXPENSES.

     (a)  Each Party will maintain complete and accurate records which are
relevant to revenues, costs, expenses and payments on a country-by-country basis
under this Agreement and such records shall be open during reasonable business
hours for a period of two (2) years from creation of individual records for
examination at the other Party's expense and not more often than once each year
by a certified public accountant selected by the other Party, or the other
Party's internal accountants unless the first Party objects to the use of such
internal accountants, for the sole purpose of verifying for the inspecting Party
the correctness of calculations and classifications of such revenues, costs,
expenses or payments made under this Agreement. Each party shall bear its own
costs related to such audit; provided, however, that, for any underpayments by a
Party greater than five percent (5%), such Party shall pay the other Party the
amount of underpayment, interest as provided for in Section 5.04(b) from the
time the

                                       25

amount was due and the other Party's out-of-pocket expenses. For any
underpayments less than five percent (5%) by a Party found under this Section,
such Party shall pay the other Party the amount of underpayment. Any
overpayments by a Party will be refunded to such Party or credited to future
royalties, at such Party's election. Any records or accounting information
received from the other Party shall be Confidential Information for purposes of
Article VII. Results of any such audit shall be provided to both Parties,
subject to Article VII.

     (b)  If there is a dispute between the Parties following any audit
performed pursuant to Section 10.03(a), either party may refer the issue (an
"AUDIT DISAGREEMENT") to an independent certified public accountant for
resolution. In the event an Audit Disagreement is submitted for resolution by
either Party, the Parties shall comply with the following procedures:

          (i)   The Party submitting the Audit Disagreement for resolution shall
  provide written notice to the other Party that it is invoking the procedures
  of this Section 10.03(b).

          (ii)  Within thirty (30) business days of the giving of such notice,
  the Parties shall jointly select a recognized international accounting firm to
  act as an independent expert to resolve such Audit Disagreement.

          (iii) The Audit Disagreement submitted for resolution shall be
  described by the Parties to the independent expert, which description may be
  in written or oral form, within ten (10) business days of the selection of
  such independent expert.

          (iv)  The independent expert shall render a decision on the matter as
  soon as practicable.

          (v)   The decision of the independent expert shall be final and
  binding unless such Audit Disagreement involves alleged fraud, breach of this
  Agreement or construction or interpretation of any of the terms and conditions
  hereof.

          (vi)  All fees and expenses of the independent expert, including any
  third party support staff or other costs incurred with respect to carrying out
  the procedures specified at the direction of the independent expert in
  connection with such Audit Disagreement, shall be borne by the Party that did
  not submit the Audit Disagreement in the event that a discrepancy of more than
  two percent (2%) results from such decision, and by each Party in inverse
  proportion to the disputed amounts awarded to the Party by the independent
  expert through such decision (e.g. Alliance disputes $100, the independent
  expert awards Alliance $50, then each party pays one-half (1/2) of the
  independent expert's costs) in all other cases.

     SECTION 10.04. APPLICABILITY. This Article X shall be applicable following
the Restatement Date (without prejudice to any rights accruing prior to the
Restatement Date) only if Schering undertakes Development or Commercialization
activities with regard to a Product following the Restatement Date or exercises
its option under Section 4.01(d).

                                       26

                                   ARTICLE XI
                              TERM AND TERMINATION

     SECTION 11.01. TERM. This Agreement shall commence as of the Effective Date
and, unless sooner terminated as provided herein shall continue in effect until
no royalties or other payments are payable hereunder to either Alliance or
Schering.

     SECTION 11.02. TERMINATION.

     (a)  Notwithstanding any other provision herein, Schering may, prior to
Regulatory Approval of a Product, terminate this Agreement on a country by
country basis or in its entirety upon one (1) month written notice to Alliance.
After receipt of Regulatory Approval of a Product and prior to the First
Commercial Sale of said Product in the applicable country, Schering may
terminate this Agreement on a country by country basis upon two (2) months
written notice to Alliance. After the First Commercial Sale of a Product,
Schering may terminate this Agreement on a country by country basis upon three
(3) months written notice to Alliance.

     (b)  Failure by Schering or Alliance to comply with any of the respective
material obligations and conditions contained in this Agreement shall entitle
the other Party to give the Party in default notice requiring it to cure such
default. If such default is not cured within ninety (90) days after receipt of
such notice, the notifying Party shall be entitled (without prejudice to any of
its other rights conferred on it by this Agreement) to terminate this Agreement
or in the event of an uncured material breach by Alliance, effect the rights of
Schering set forth in Section 11.02(e) by giving a notice to take effect
immediately. Notwithstanding the foregoing, in the event of a non-monetary
default, if the default is not reasonably capable of being cured within the
ninety (90) day cure period by the defaulting Party and such defaulting Party is
making a good faith effort to cure such default, the notifying Party may not
terminate this Agreement, provided however, that the notifying Party may
terminate this Agreement if such default is not cured within one hundred eighty
(180) days of such original notice of default. The right of either Party to
terminate this Agreement as hereinabove provided shall not be affected in any
way by its waiver of, or failure to take action with respect to any previous
default.

     (c)  In the event that one of the Parties hereto shall go into liquidation,
a receiver or a trustee be appointed for the property or estate of that Party
and said receiver or trustee is not removed within sixty (60) days, or the Party
makes an assignment for the benefit of creditors (collectively, a "BANKRUPTCY
EVENT"), and whether any of the aforesaid Bankruptcy Events be the outcome of
the voluntary act of that Party, or otherwise, the other Party shall be entitled
to terminate this Agreement (or in the event Alliance suffers such a Bankruptcy
Event, Schering may effect its rights described in Section 11.02(e) forthwith by
giving a written notice to Alliance.

     (d)  In the event that this Agreement is terminated by Schering in one or
more countries or in its entirety, and in the event that the Agreement is
terminated by either Party in its entirety in accordance with Sections 11.02(a),
(b) or (c) hereof, Schering will with respect to each country for which the
termination applies entirely:

                                       27

          (i)   deliver to Alliance the Alliance Know-How and assign to Alliance
  its rights in said Alliance Know-How and Alliance Patents if any, in either
  case relating solely to the country that is the subject of the termination;

          (ii)  not use the Alliance Know-How as long as it has to be kept
  confidential pursuant to Article VII hereof in such country;

          (iii) not infringe any of the Alliance Patents in such country;

          (iv)  make all payments accrued under this Agreement with respect to
  such country prior to the effective termination date;

          (v)   transfer all regulatory filings and approvals related to the
  Product in such country to Alliance upon Alliance's written request for same;

          (vi)  transfer to Alliance responsibility for and control of ongoing
  work of Schering related to the Product, Affiliates and Third Parties in an
  expeditious and orderly manner with the costs for such work assumed by
  Alliance as of the date of notice; and

          (vii) sell to Alliance, at any time within ninety (90) days of such
  termination, at Alliance's election, all or any portion of the inventory of
  the Product owned by Schering or its Affiliates which are intended for sale in
  such country at a price equal to Schering's or its Affiliate's cost for such
  inventory. Such election shall be made by Alliance in writing and within
  thirty (30) days of such election, Schering shall ship at Alliance's cost and
  direction such inventory to Alliance. Alliance shall pay for such inventory
  within forty-five (45) days of receipt of such inventory.

     (e)  In the event of a Bankruptcy Event or a material default described in
Sections 11.02(b) and (c) by Alliance (which default is not cured as provided
therein), Schering may elect in lieu of terminating this Agreement to declare
the license granted pursuant to this Agreement to be irrevocable. From the date
of receipt of notice of such election, Alliance shall have no further rights or
obligations under this Agreement, except that Alliance may enforce any financial
obligations of Schering, including those arising under Article V herein before
or after such election, and Schering may enforce any manufacturing and supply
obligations of Alliance, including those arising under Section 11.02(f);
provided, however, that if such election occurs prior to the First Commercial
Sale of the Product, any additional Development Expenses and reasonable costs
incurred by Schering to Commercialize the Product as a result of such election
shall be credited against amounts payable by Schering to Alliance.

     (f)  In the event of termination of this Agreement pursuant to this Section
11.02 where the Party terminating this Agreement is the Manufacturing Party, the
Manufacturing Party shall continue to provide for manufacture of the Product to
the extent provided prior to notice of such termination, from the effective date
of such termination until such time as the Non-Manufacturing Party is able to
secure an equivalent alternative commercial manufacturing source, as requested
by the Non-Manufacturing Party.

                                       28

     (g)  Except where expressly provided for otherwise in this Agreement,
termination of this Agreement shall not relieve the Parties hereto of any
liability, including any obligation to make payments hereunder, which accrued
hereunder prior to the effective date of such termination, nor preclude any
Party from pursuing all rights and remedies it may have hereunder or at law or
in equity with respect to any breach of this Agreement nor prejudice any Party's
right to obtain performance of any obligation.

     SECTION 11.03. SURVIVING RIGHTS. The rights and obligations set forth in
this Agreement shall extend beyond the term or termination of the Agreement only
to the extent expressly provided for herein, or the extent that the survival of
such rights or obligations are necessary to permit their complete fulfillment or
discharge.

                                   ARTICLE XII
                                 INDEMNIFICATION

     SECTION 12.01. INDEMNIFICATION. With respect to the Product (determined on
a country by country basis):

     (a)  Schering and Alliance hereby agree to save, defend and hold the other
Party and its agents and employees harmless from and against any and all suits,
claims, actions, demands, liabilities, expenses and/or losses, including
reasonable legal expenses and attorneys' fees (collectively, "LOSSES") resulting
directly from the Development or Commercialization of the Product to the extent
such Development or Commercialization was performed by such Party except to the
extent such Losses result from the negligence or willful misconduct of the other
Party, in which case such Party hereby agrees to save, defend and hold the other
Party and its agents and employees harmless from any and all such Losses.

     (b)  Each indemnified Party agrees to give the indemnifying Party prompt
written notice of any Loss or discovery of fact upon which such indemnified
Party intends to base a request for indemnification under Sections 12.01(a).
Each Party shall furnish promptly to the other copies of all papers and official
documents received in respect of any Loss. With respect to any Loss relating
solely to the payment of money damages and which will not result in the
indemnified Party becoming subject to injunctive or other relief or otherwise
adversely affecting the business of the indemnified Party in any manner, and as
to which the indemnifying Party shall have acknowledged in writing the
obligation to indemnify the indemnified Party hereunder, the indemnifying Party
shall have the sole right to defend, settle or otherwise dispose of such Loss,
on such terms as the indemnifying Party, in its sole discretion, shall deem
appropriate. The indemnifying Party shall obtain the written consent of the
indemnified Party, which shall not be unreasonably withheld or delayed, prior to
ceasing to defend, settling or otherwise disposing of any Loss if as a result
thereof the indemnified Party would become subject to injunctive or other
equitable relief or any remedy other than the payment of money, which payment
would be the responsibility of the indemnifying Party. The indemnifying Party
shall not be liable for any settlement or other disposition of a Loss by the
indemnified Party which is reached without the written consent of the
indemnifying Party. The reasonable costs and expenses, including reasonable fees
and disbursements of counsel incurred by any

                                       29

indemnified Party in connection with any Loss, shall be reimbursed on a
quarterly basis by the indemnifying Party, without prejudice to the indemnifying
Party's right to contest the indemnified Party's right to indemnification and
subject to refund in the event the indemnifying party is ultimately held not to
be obligated to indemnify the indemnified Party.

                                  ARTICLE XIII
                                  MISCELLANEOUS

     SECTION 13.01. ASSIGNMENT.

     (a)  Schering may assign any of its rights or obligations under this
Agreement in any country to any of its Affiliates or to any sublicensee as
provided in Section 3.01; provided, however, that such assignment shall not
relieve Schering of its responsibilities for performance of its obligations
under this Agreement.

     (b)  Alliance may assign any of its rights or obligations under this
Agreement in any country to any of its Affiliates or to any sublicensee if
permitted by Section 3.02; provided, however, that such assignment shall not
relieve Alliance of its responsibilities for performance of its obligations
under this Agreement.

     (c)  Either Party may assign its rights or obligations under this Agreement
in connection with a merger or similar reorganization or the sale of all or
substantially all of its assets, or otherwise with the prior written consent of
the other Party. This Agreement shall survive any such merger or reorganization
of either Party with or into, or such sale of assets to, another Party and no
consent for such merger, reorganization or sale shall be required hereunder;
provided, that in the event of such merger, reorganization or sale, no
intellectual property rights of the acquiring corporation shall be included in
the technology licensed hereunder.

     (d)  This Agreement shall be binding upon and inure to the benefit of the
successors and permitted assigns of the Parties. Any assignment not in
accordance with this Agreement shall be void.

     SECTION 13.02. RETAINED RIGHTS. Nothing in this Agreement shall limit in
any respect the right of either Party to conduct research and development and to
market products using such Party's technology other than as herein expressly
provided.

     SECTION 13.03. FORCE MAJEURE. Neither Party shall lose any rights hereunder
or be liable to the other Party for damages or losses on account of failure of
performance by the defaulting Party if the failure is occasioned by government
action, war, fire, explosion, flood, strike, lockout, embargo, act of God, or
any other cause beyond the control of the defaulting Party, provided that the
Party claiming force majeure has extended all reasonable efforts to avoid or
remedy such force majeure, continues to employ such efforts and promptly
notifies the other Party of such force majeure event.

                                       30

     SECTION 13.04. FURTHER ACTIONS. Each Party agrees to execute, acknowledge
and deliver such further instruments, and to do all such other acts, as may be
necessary or appropriate in order to carry out the purposes and intent of this
Agreement.

     SECTION 13.05. NO TRADEMARK RIGHTS. Except as otherwise provided herein,
no right, express or implied, is granted by the Agreement to use in any manner
the name "Schering," or any other trade name or trademark of the other Party or
its Affiliates in connection with the performance of the Agreement.

     ARTICLE 13.06. NOTICES. All notices hereunder shall be in writing and
shall be deemed given if delivered personally, mailed by registered or certified
mail (return receipt requested), postage prepaid, or sent by express courier
service, to the Parties at the following addresses (or at such other address for
a Party as shall be specified by like notice; provided, however, that notices of
a change of address shall be effective only upon receipt thereof).

     (a)  If to Alliance:

          Alliance Pharmaceutical Corp.
          3040 Science Park Road
          San Diego, CA 92121
          Attention: President
          Telecopy:  (619) 558-5161

          With a copy to:

          Stroock & Stroock & Lavan LLP
          180 Maiden    Lane
          New York, NY 10038-4982
          Attention: Melvin Epstein
          Telecopy:  (212) 806-6006

     (b)  If to Schering:

          Schering AG
          13342 Berlin
          Germany
          Attention: Legal Department
          Telecopy:  ++49-30-4681 4086

          With a copy to:

          Schering AG
          13342 Berlin
          Germany
          Attention: SBU Diagnostics & Radiopharmaceuticals
          Telecopy: ++49-30-4681 6736

                                       31

     SECTION 13.07. WAIVER. Except as specifically provided for herein, the
waiver from time to time by either of the Parties of any of their rights or
their failure to exercise any remedy shall not operate or be construed as a
continuing waiver of same or any other of such Party's rights or remedies
provided in this Agreement.

     SECTION 13.08. SEVERABILITY. If any term, covenant or condition of this
Agreement or the application thereof to any Party or circumstances shall, to any
extent or in any country, be held to be invalid or unenforceable, then (i) the
remainder of this Agreement, or the application of such term, covenant or
condition to Parties or circumstances other than those as to which it is held
invalid or unenforceable, shall not be affected thereby and each term, covenant
or condition of this Agreement shall be valid and be enforced to the fullest
extent permitted by law; and (ii) the Parties hereto covenant and agree to
renegotiate any such term, covenant or application thereof in good faith in
order to provide a reasonably acceptable alternative to the term, covenant or
condition of this Agreement or the application thereof that is invalid or
unenforceable, it being the intent of the Parties that the basic purposes of
this Agreement are to be effectuated.

     SECTION 13.09. AMBIGUITIES. Ambiguities, if any, in this Agreement shall
not be construed against any Party, irrespective of which Party may be deemed to
have authored the ambiguous provision.

     SECTION 13.10. GOVERNING LAW. This Agreement shall be governed by and
interpreted under the laws of the State of New York as applied to contracts
entered into and performed entirely in New York by New York residents.

     SECTION 13.11. HEADINGS. The sections and paragraph headings contained
herein are for the purposes of convenience only and are not intended to define
or limit the contents of said sections or paragraphs.

     SECTION 13.12. COUNTERPARTS. This Agreement may be executed in one or more
counterparts (and by facsimile), each of which shall be deemed an original, but
all of which together shall constitute one and the same instrument.

     SECTION 13.13. ENTIRE AGREEMENT; AMENDMENTS. This Agreement, including all
Exhibits attached hereto and thereto, and all documents delivered concurrently
herewith and therewith, set forth all the covenants, promises, agreements,
warranties, representations, conditions and understandings between the Parties
hereto and supersede and terminate all prior agreements and understandings
between the Parties. There are no covenants, promises, agreements, warranties,
representations, conditions or understandings, either oral or written, between
the Parties other than as set forth herein and therein. No subsequent
alteration, amendment, change or addition to this Agreement shall be binding
upon the Parties hereto unless reduced to writing and signed by the respective
authorized officers of the Parties. This Agreement, including without limitation
the exhibits, schedules and attachments thereto, are intended to define the full
extent of the legally enforceable undertakings of the Parties hereto,

                                       32

and no promise or representation, written or oral, which is not set forth
explicitly is intended by either party to be legally binding. Both Parties
acknowledge that in deciding to enter into the Agreement and to consummate the
transaction contemplated thereby neither has relied upon any statement or
representations, written or oral, other than those explicitly set forth therein.

     SECTION 13.14. EXPENSES. Except as otherwise specified in this Agreement,
all costs and expenses, including, without limitation, fees and disbursements of
counsel, financial advisors and accountants, incurred in connection with this
Agreement and the transactions contemplated hereby shall be paid by the Party
incurring such costs and expenses.

     SECTION 13.15. INDEPENDENT CONTRACTORS. The status of the Parties under
this Agreement shall be that of independent contractors. Neither Party shall
have the right to enter into any agreements on behalf of the other Party, nor
shall it represent to any person that it has any such right or authority.
Nothing in this Agreement shall be construed as establishing a partnership or
joint venture relationship between the Parties.

     SECTION 13.16. USE OF NAMES. Neither Party shall use the name of the other
Party in relation to this transaction in any public announcement, press release
or other public document without the written consent of such other Party, which
consent shall not be unreasonably withheld or delayed; provided, however, that
either Party may use the name of the other Party in any document filed with any
regulatory agency or authority, including the FDA and the Securities and
Exchange Commission, in which case Schering shall be referred to as "Schering
AG, Germany". Alliance agrees not to use the name "Schering" in relation to this
transaction in any press release, public announcement or other public document
without the approval of Schering, which approval shall not be unreasonably
withheld or delayed.

     IN WITNESS WHEREOF, Alliance and Schering have caused this Agreement to be
executed as of the date first written above by their respective officers
thereunto duly authorized.

                                             ALLIANCE PHARMACEUTICAL CORP

                                             By:
                                                   ----------------------------
                                             Name:
                                             Title:

                                             SCHERING AKTIENGESELLSCHAFT

                                             By:
                                                   ----------------------------
                                             Name:  Hans-Michael Rook
                                             Title: Head of SBU DG & RP

                                       33

                                             By:
                                                    ---------------------------
                                             Name:  Dr. Thomas Fritzsch
                                             Title: Licensing and Cooperations
                                                    DG & RP

                                       34

                                    EXHIBIT A

                    DETERMINATION OF CERTAIN ACCOUNTING TERMS

     As a supplement to the definitions provided in Article I of the License
Agreement (this "AGREEMENT"), originally dated as of September 23, 1997, and
amended and restated in its entirety as of February 22, 2002 between ALLIANCE
PHARMACEUTICAL CORP. and SCHERING AKTIENGESELLSCHAFT, the following accounting
terms shall be further specified as follows, with the intent that the following
terms are to be interpreted in accordance with their reasonable and customary
meaning within the industry and consistently applied by a Party on a
company-wide basis:

  1. COST OF GOODS

     Cost of Goods shall be equal to the sum of Material Costs, Direct Labor
costs and Indirect Costs.

          A. "MATERIAL COSTS" shall mean the prices paid for raw material
  components and purchased finished goods, including any packaging necessary for
  the shipment of products, which are purchased from outside vendors as well as
  any freight and duty where applicable.

          B. "DIRECT LABOR COSTS" shall mean the labor hours required for an
  operation for such a Product multiplied by the direct labor rate for work
  centers within the relevant manufacturing operating unit (including salaries,
  wages and benefits).

          C. "INDIRECT COSTS" shall mean other costs associated with the
  operating unit(s) manufacturing a Product; provided, however, overhead
  attributable to unrelated facilities, or parts thereof, shall be excluded and
  that such Indirect Costs shall exclude costs associated with unused
  manufacturing capacity. Indirect Costs shall include expenses associated with
  quality assurance, manufacturing and engineering associated with the operating
  unit(s) manufacturing a Product and shall include straight line depreciation
  and property taxes specifically associated with the plant(s) manufacturing a
  Product.

                                       A-1

                                    EXHIBIT B

                                ALLIANCE PATENTS

                        --------------------------------
                                  PATENT NUMBER
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------

                                       B-1

                                    EXHIBIT C

                               ALLIANCE HI PATENTS

                        --------------------------------
                                  PATENT NUMBER
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------
                                        [****]
                        --------------------------------

                                       C-1

                                    EXHIBIT D

                               SCHERING HI PATENTS

-----------------------                         -----------------------
        INT. NO.                                        INT. NO.
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]                                               [****]
-----------------------                         -----------------------
          [****]
-----------------------                         -----------------------
          [****]
-----------------------                         -----------------------
          [****]                                                [****]
-----------------------                         -----------------------
          [****]
-----------------------                         -----------------------

                                       D-1Unassociated Document

    

      CONFIDENTIAL
        TREATMENT REQUESTED: Certain portions of this document have been
        omitted pursuant to a request for confidential treatment and, where applicable,
        have been marked with an asterisk (“[****]”) to denote where omissions have been
        made. Note that one page of this exhibit contains omitted material pursuant
        to
        this request. The confidential material has been filed separately with the
        Securities and Exchange Commission.

      

      

      SETTLEMENT
        & WORLDWIDE LICENSE AGREEMENT

      

      AGREEMENT
        (“Agreement”) made as of January 31, 2001, (the “Effective Date”), by and among
        Bracco International B.V. (“Bracco”), a Netherlands corporation having a place
        of business at 3051 Strawinskylaan, 1077 ZX Amsterdam, Netherlands; Schering
        Aktiengesellschaft (“Schering”), a German corporation having a place of business
        at Mullerstrasse 178, 13342 Berlin-Wedding, Germany; and Alliance Pharmaceutical
        Corp. (“Alliance”), a New York corporation having a place of business at 3040
        Science Park Road, San Diego, California 92121. Bracco, Schering, and Alliance
        may be referred to separately as a “Party” or collectively as the
“Parties”.

       

      WHEREAS,
        Bracco possesses intellectual property relating to the formulation method
        of
        preparing or use of Microbubbles (as this term is defined below);

       

      WHEREAS,
        Alliance possesses intellectual property relating to the formulation method
        of
        preparing or use of Microbubbles;

       

      WHEREAS,
        Schering possesses intellectual property relating to the formulation method
        of
        preparing or use of Microbubbles;

       

      WHEREAS,
        Schering and Alliance have entered into a License Agreement under which Alliance
        granted to Schering an exclusive worldwide license with a right to sublicense
        under the Alliance Patents as defined therein;

       

      WHEREAS,
        there is pending before the United States Patent and Trademark Office
        Interference No. 104,427 between Bracco and Alliance; and

       

      WHEREAS,
        the Parties desire to settle the interference and all potential intellectual
        property disputes relating to their future and planned activities involving
        certain Products (as this term is defined below) or Microbubbles that have
        been
        or are currently being developed or may be developed in the future.

       

      NOW,
        THEREFORE, in consideration of the foregoing and the covenants and
        acknowledgements and representations contained in this Agreement, the Parties
        hereby agree as follows:

       

       

      ARTICLE
        I.  DEFINITIONS

       

      1.1.  Definitions.
        For
        purposes of this Agreement, the terms defined in this Article shall have
        the
        meanings specified below. These terms are intended to encompass both the
        singular and plural forms.

       

      
        
          
          

        

        
          1

          
            

          

        

        
          
          

        

      

       

      
        	1.1.1  	
                “Affiliate”
                  shall mean a person or an entity that controls, is controlled by,
                  or is
                  under common control with a Party to this
                  Agreement.

              

      

       

      
        	1.1.2  	
                “Alliance”
                  shall mean Alliance as identified as a Party above and any Affiliate
                  of
                  Alliance.

              

      

       

      
        	1.1.3  	
                “Alliance
                  Licensed Patents”
                  shall mean Licensed Patents which are owned, obtained, acquired,
                  purchased
                  by or licensed to, with a right to sublicense, or in any way under
                  the
                  control or at disposal of Alliance, except for Third Party patents
                  and
                  patent applications acquired after December 20, 2000 by Alliance
                  which,
                  prior to their acquisition and not as a result of the negotiations
                  leading
                  up to such acquisition, had been previously exclusively licensed
                  or
                  otherwise exclusively restricted to any Third
                  Party.

              

      

       

      
        	1.1.4  	
                “BR-1”
                  shall mean a phospholipid-stabilized Microbubble formulation not
                  prepared
                  by freeze drying wherein the fluorine atoms contained in the Microbubbles
                  are in the form of SF6.

              

      

       

      
        	1.1.5  	
                “BR-14”
                  shall mean a phospholipid-stabilized Microbubble formulation not
                  prepared
                  by spray drying wherein the fluorine atoms contained in the Microbubbles
                  are in the form of CF4,
                  C2F6,
                  C3F6,
                  C4F10
                  or
                  mixtures thereof.

              

      

       

      
        	1.1.6  	
                “Bracco”
                  shall mean Bracco as identified as a Party above and any Affiliate
                  of
                  Bracco.

              

      

       

      
        	1.1.7  	
                “Bracco
                  Licensed Patents”
                  shall mean Licensed Patents which are owned, obtained, acquired,
                  purchased
                  or licensed to, with a right to sublicense, or in any way under
                  the
                  control or at disposal of Bracco, except for Third Party patents
                  and
                  patent applications acquired after December 20, 2000 by Bracco
                  which,
                  prior to their acquisition and not as a result of the negotiations
                  leading
                  up to such acquisition, had been previously exclusively licensed
                  or
                  otherwise exclusively restricted to any Third
                  Party.

              

      

       

      
        	1.1.8  	
                “Distributor”
                  shall mean any Third Party engaged solely in the shipping, transportation,
                  or distribution of any product, whether or not owned by a
                  Party.

              

      

       

      
        	1.1.9  	
                “Imavist”
                  shall mean a phospholipid-stabilized Microbubble formulation not
                  prepared
                  by freeze drying wherein the fluorine atoms contained in the Microbubble
                  are in the form of C6F14.

              

      

       

      
        	1.1.10  	
                “Imavist
                  II”
                  shall mean a phospholipid-stabilized Microbubble formulation not
                  prepared
                  by freeze drying wherein the fluoride atoms contained in the Microbubble
                  are in the form of C6F14 or any three fluoroether species or any
                  combination thereof to be named by Alliance within five years of
                  the
                  Effective Date of this Agreement.

              

      

       

       

      
        
          
          

        

        
          2

          
            

          

        

        
          
          

        

      

       

      
        	1.1.11  	
                “Joint
                  Development Parties”
                  shall mean any Third Party engaged in the development, manufacture,
                  sale,
                  use, exportation or importation of a Party’s
                  Product(s).

              

      

       

      
        	1.1.12  	
                “Licensed
                  Patents”
                  shall mean all present and future patent and patent application
                  claims,
                  worldwide, that are directed to Microbubbles, formulations of
                  Microbubbles, intermediates used in making Microbubbles, methods
                  of
                  preparing Microbubbles or the use of Microbubbles in Ultrasound
                  Imaging
                  (including harmonic imaging) that cover a Product, method of preparing
                  a
                  Product or method of using a Product, provided that such patent
                  and patent
                  application claims shall not include those directed to (i) non-Ultrasound
                  Imaging uses of Microbubbles such as uses in drug delivery; gene
                  therapy;
                  sonothrombolysis; magnetic resonance imaging; and oxygen delivery,
                  and
                  (ii) Microbubbles with targeting ligands, peptides or chelates
                  and
                  formulations, intermediates for, methods of preparing and the use
                  of
                  same.

              

      

       

      
        	1.1.13  	
                “Medical
                  Diagnostic Imaging Field”
                  shall mean any in
                  vivo
                  imaging of at least a portion of a patient, including but not limited
                  to
                  radiopharmaceutical, ultrasound, MRI, X-ray and light
                  imaging.

              

      

       

      
        	1.1.14  	
                “Microbubbles”
                  shall mean microbubbles, microspheres, microballoons, microparticles
                  and/or microvesicles containing gas or gas
                  mixtures.

              

      

       

      
        	1.1.15  	
                “Physiologically
                  Acceptable Gas”
                  shall mean a gas selected from air, nitrogen, oxygen, carbon dioxide,
                  helium, xenon or mixtures thereof.

              

      

       

      
        	1.1.16  	
                “Products”
                  shall mean Imavist or Imavist II in the case of Alliance or Schering,
                  and
                  BR-1 or BR-14 in the case of
                  Bracco.

              

      

       

      
        	1.1.17  	
                “Schering”
                  shall mean Schering as identified as a Party above and any Affiliates
                  of
                  Schering.

              

      

       

      
        	1.1.18  	
                “Schering
                  Licensed Patents”
                  shall mean Licensed Patents which are owned, obtained, acquired,
                  purchased
                  by or licensed to, with a right to sublicense, or in any way under
                  the
                  control or at disposal of Schering, except for Third Party patents
                  and
                  patent applications acquired after December 20, 2000 by Schering
                  which,
                  prior to their acquisition and not as a result of the negotiations
                  leading
                  up to such acquisition, had been previously exclusively licensed
                  or
                  otherwise exclusively restricted to any Third
                  Party.

              

      

       

      
        	1.1.19  	
                “Third
                  Party”
                  shall mean any entity other than Bracco, Alliance, or Schering,
                  including
                  any person or other entity that controls, is controlled by, or
                  is under
                  common control with that entity.

              

      

       

       

      
        
          
          

        

        
          3

          
            

          

        

        
          
          

        

      

       

      
        	1.1.20  	
                “Ultrasound
                  Imaging”
                  shall mean the in
                  vivo
                  imaging of at least a portion of a patient with ultrasound, including
                  but
                  not limited to harmonic imaging.

              

      

       

       

      ARTICLE
        II.  WORLDWIDE
        GRANT OF INTELLECTUAL PROPERTY RIGHTS

       

      2.1.  Bracco
        hereby grants an irrevocable worldwide nonexclusive license to Schering and
        Alliance under the Bracco Licensed Patents to make, have made, use, sell,
        offer
        to sell, import Imavist and/Imavist II, whether or not Imavist and/or Imavist
        are combined with other elements and used outside the coverage of the Licensed
        Patents. This license of the instant provision 2.1 includes the right to
        sublicense such rights to current and future Distributors and Joint Development
        Partners.

       

      2.2.  Schering
        hereby grants an irrevocable worldwide nonexclusive license to Bracco under
        the
        Schering Licensed Patents to make, have made, use, sell, offer to sell, import
        or export BR-1 and/or BR-14, whether or not BR-1 and/or BR-14 are combined
        with
        other elements and used outside the coverage of the Licensed Patents. This
        license of the instant provision 2.2 includes the right to sublicense such
        rights to current and future Distributors and Joint Development
        Partners.

       

       

      ARTICLE
        III.  WORLDWIDE
        SETTLEMENT OF INTELLECTUAL PROPERTY DISPUTES

       

      3.1.  It
        is the
        intention of the Parties to settle any and all current and potential
        intellectual property disputes pertaining to the Licensed Products so as
        to
        obtain freedom to market their respective Products and therefor the Parties
        have
        voluntarily entered into this Agreement. In that connection, the Parties
        shall:

       

      
        	3.1.1  	
                withdraw
                  all current oppositions brought against the Licensed Patents of
                  another
                  Party in countries foreign to the United
                  States;

              

      

       

      
        	3.1.2  	
                refrain
                  from filing any future oppositions or other challenge against the
                  Licensed
                  Patents of another Party in countries foreign to the United
                  States;

              

      

       

      
        	3.1.3  	
                refrain
                  from filing any requests for interference, reexamination or other
                  challenge against the Licensed Patents of another Party in the
                  United
                  States; and

              

      

       

      
        	3.1.4  	
                in
                  the event an interference is declared by the United States Patent
                  and
                  Trademark Office (“PTO”), meet and cooperate in good faith to find a joint
                  settlement in a timely and efficient manner consistent with the
                  requirements of 35 U.S.C. § 135 and other applicable laws and
                  regulations.

              

      

       

      3.2.  In
        order
        to advance the resolution of PTO interference No. 104,427 (the “Interference”),
        Bracco and Alliance counsel have met, exchanged information and determined
        in
        good faith and in order to resolve the Interference in just, timely and
        efficient manner, to proceed as follows:

       

      
        
          
          

        

        
          4

          
            

          

        

        
          
          

        

      

       

      
        	3.2.1  	
                Alliance
                  will file three motions in the Interference, namely, (1) a motion
                  to
                  [****], (2) a motion to [****], and (3)
                  a motion to be
[****].

              

      

       

      
        	3.2.2  	
                Bracco
                  will file papers in the Interference stating that it will not oppose
                  the
                  two motions set forth in Section 3.2.1 above and requesting entry
                  of an
                  adverse judgment against Bracco on Count
                  2.

              

      

       

      
        	3.2.3  	
                Bracco
                  will file motions in the Interference [****] Schneider
                  AAA application, which claims are set forth in Exhibits B and C
                  annexed
                  hereto) and accompanying motions for
                  benefit.

              

      

       

      
        	3.2.4  	
                Alliance
                  will file papers in the Interference stating that it will not oppose
                  the
                  motions set forth in Section 3.2.3 above and requesting entry of
                  an
                  adverse judgment against Alliance on the Proposed
                  Counts.

              

      

       

      
        	3.2.5  	
                Bracco
                  and Alliance will generally cooperate in a reasonable manner in
                  filing the
                  motions and papers identified above. In this regard, Bracco and
                  Alliance
                  will file no other motions or other papers in the Interference
                  other than
                  those that are identified in Sections 3.2.1, 3.2.2, 3.2.3 and 3.2.4
                  above
                  and 3.3 below unless they are reasonably necessary to effectuate
                  the
                  above. If, however, after the Parties file these motions and papers,
                  the
                  PTO comes to some other judgment that does not include awarding
                  Alliance
                  judgment for Count 2 and either awarding Bracco judgment for the
                  Proposed
                  Counts or denying or dismissing the motions for the Proposed Counts
                  (e.g.,
                  the PTO sua sponte
                  corresponds some or all of the claims that make up Count 2 and
                  some or all
                  of the claims that make up the Proposed Counts to a single count
                  in the
                  original interference or in a new interference), then Bracco and
                  Alliance
                  will confer on an appropriate way to advance the resolution of
                  the
                  Interference. If agreement on such an appropriate way to advance
                  the
                  resolution cannot be reached, Bracco and Alliance will be free
                  to file any
                  motions or other papers to pursue any
                  outcome.

              

      

       

      3.3.  Bracco
        and Alliance will file all agreements and understandings regarding the
        Interference, including this Agreement, with the PTO as required by 35 U.S.C.
        § 135(c).

       

      3.4.  In
        the event the [****] application, the [****]
        application and/or an application claiming priority from the
[****] application or the [****] application
        issues as a United States patent, Bracco will grant [****]
        under any such patent for any products or methods used outside of the Medical
        Diagnostic Imaging Field. Notwithstanding the foregoing, the license set
        forth
        in this Section 3.4 shall not include any other Bracco patent or patent
        application, even if the patent or patent application has claims that are
        the
        same or similar to the New Claims, provided that the patent does not issue
        from
        the [****] application, the [****] application
        or an application that claims priority from the [****]
        application or the [****] application.

       

      
        
          
          

        

        
          5

          
            

          

        

        
          
          

        

      

       

      3.5.  Neither
        Bracco nor Alliance will, in the future, assert an issue preclusion defense
        in
        any proceeding, other than an interference proceeding in the PTO, based upon
        the
        other Party requesting entry of an adverse judgment pursuant to Sections
        3.2.2
        and 3.2.4 above.

       

      3.6.  The
        licenses set forth in this Agreement shall not be affected in any way by
        any
        outcome of the Interference.

       

       

      ARTICLE
        IV.  FIRST
        RIGHT OF NEGOTIATION

       

      4.1.  If
        Alliance’s license of Imavist to Schering is terminated, Alliance will give
        Bracco a first right of negotiation for any rights to Imavist returned to
        Alliance as a result of such termination, which right of negotiation will
        be for
        ninety (90) days starting at the time Alliance informs Bracco that it desires
        a
        development/marketing partner for Imavist II.

       

      4.2.  Alliance
        hereby grants to Bracco, subject to any rights of Schering, a first right
        of
        negotiation for worldwide rights (e.g., development and marketing) to Imavist
        II
        which right of negotiation will be for a one hundred and twenty (120) day
        period
        starting at the time Alliance informs Bracco that it desires a development
        marketing partner for Imavist II.

       

       

      ARTICLE
        V.  EFFECT
        OF AGREEMENT ON THIRD PARTIES

       

      5.1.  Nothing
        in this Agreement shall be construed to (1) obligate any Party to bring any
        action against any Third Party based on such Party’s Licensed Patents, or (2)
        limit or affect a Party’s right to bring any action against any Third Party
        based on such Party’s Licensed Patents.

       

      5.2.  Nothing
        in this Agreement shall be construed to (1) obligate any Party to negotiate
        with
        or obtain licenses from any Third Party, or (2) limit or affect a Party’s rights
        to negotiate or obtain licenses from any Third Party.

       

       

      ARTICLE
        VI.  FEES,
        PAYMENTS, ROYALTIES, WARRANTIES, INDEMNIFICATION

       

      6.1.  No
        party
        shall have any obligation to make any payments to the other Parties pursuant
        to
        this Agreement. Each Party shall bear its own costs and expenses, including,
        without limitation, its attorneys fees, relating to any action to be taken
        or
        having been taken in respect to this Agreement.

       

      6.2.  Each
        Party makes the following warranties and representations to the other
        Parties:

       

      
        	6.2.1  	
                each
                  Party is a corporation duly organized and validly existing and
                  in good
                  standing under the laws of the state or country in which it is
                  organized
                  and has all requisite power and authority to enter into and perform
                  this
                  Agreement and the transactions contemplated hereby and to require
                  its
                  Affiliates to abide by its terms and
                  conditions;

              

      

       

      
        
          
          

        

        
          6

          
            

          

        

        
          
          

        

      

       

      
        	6.2.2  	
                all
                  requisite corporate actions on the part of each Party has been
                  completed
                  for the authorization of the execution and delivery of this Agreement
                  and
                  the performance of the transactions contemplated
                  hereunder.

              

      

       

      
        	6.2.3  	
                this
                  Agreement is, and such other transactions will be, valid and binding
                  obligations of each Party enforceable in accordance with their
                  respective
                  terms; and

              

      

       

      
        	6.2.4  	
                the
                  execution, delivery and performance of this Agreement and the consummation
                  of transactions contemplated hereby do not and will not violate
                  the
                  provisions of any Party’s certificate of incorporation or bylaws or
                  similar type documents or the provisions of any note, indenture,
                  lease,
                  license permit or other instrument or obligation or violate any
                  law,
                  order, rule or regulation applicable to
                  it.

              

      

       

      6.3.  No
        Party
        makes any warranties or representations, either express or implied, concerning
        the scope, validity or enforceability of its respective Licensed
        Patents.

       

      6.4.  No
        party
        shall have any obligation to indemnify any other Party for any lawsuit arising
        in connection with Imavist, Imavist II, BR-1 or BR-14, or the Schering, Alliance
        or Bracco Licensed Patents.

       

      6.5.  No
        Party
        makes any warranties or representations, either express or implied, or assumes
        any responsibility whatsoever with respect to the manufacture, use or sale
        or
        other disposition by any other Party of that Party’s Product, even if that
        Party’s Product makes use of any inventions claimed in the Licensed Patents of
        another Party.

       

       

      ARTICLE
        VII.  DURATION

       

      7.1.  The
        term
        of the license granted from Bracco to Schering and Alliance set forth in
        Section
        2.1 above and the Schering and/or Alliance obligations set forth in Section
        3
        above shall start at the Effective Date and shall last until Imavist and
        Imavist
        II are no longer under development or planned for development, undergoing
        regulatory approval, or being manufactured, sold or prepared for sale by
        either
        Schering or Alliance.

       

      7.2.  The
        term
        of the license granted from Schering and/or Alliance to Bracco set forth
        in
        Sections 2.2 and 2.3 above and the Bracco obligations set forth in Section
        3
        above shall start at the Effective Date and shall last until BR-1 and
        BR-14 are
        no
        longer under development or planned for development, undergoing regulatory
        approval, or being manufactured, sold or prepared for sale by
        Bracco.

       

       

      ARTICLE
        VIII.  CONFIDENTIALITY

       

      8.1.  Each
        Party will maintain the other Party’s information in confidence. No party will
        disclose the contents of this Agreement to any other person or entity and
        each
        Party will retain in confidence the terms and conditions of this Agreement,
        except as necessary to comply with law or the valid order of a court or agency
        of competent jurisdiction of a state or federal authority; or to the extent
        necessary in any action, suit or proceeding to enforce this Agreement or
        to
        their respective Affiliates, banks, auditors, accountants, lawyers, and any
        other representative of a Party who has a good faith need to know, provided
        that
        any such person or entity to whom disclosure is made must be advised of the
        confidentiality of the information disclosed and agree to keep such information
        confidential.

       

      
        
          
          

        

        
          7

          
            

          

        

        
          
          

        

      

       

      8.2.  No
        public
        statements of any kind pertaining to this Agreement may be made except as
        required by law, such as that enforced by the Securities Exchange Commission
        of
        the United States of America.

       

       

      ARTICLE
        IX.  MISCELLANEOUS

       

      9.1.  Notice.
        All
        notices or communications required pursuant to this Agreement shall be in
        writing and shall be deemed to have been duly given upon the date of receipt
        if
        delivered by hand, international overnight courier, confirmed facsimile
        transmission, or registered or certified mail (return receipt requested,
        postage
        prepaid) to the following addressees or facsimile numbers:

       

      
        	9.1.1  	
                For
                  Alliance:

              

      

                      Alliance
        Pharmaceutical

      3040
        Science Park Road

      San
        Diego, CA 92121

      USA

      Attn:
        President

      Facsimile:
        +1-858-410-5343

       

      
        	9.1.2  	
                For
                  Bracco:

              

      

                      Bracco
        Imaging
        S.p.A.

      Via
        Egidio Follé 50

      20
        134
        Milano, ITALY

      Attn:
        Director, Intellectual Property

      Facsimile:
        +39-02-2177-2785

       

      
        	9.1.3  	
                For
                  Schering:

              

      

                      Schering
        Aktiengesellschaft

      13342
        Berlin

      Germany

      Attn:
        Legal Department

      Facsimile:
        +49-30-4681-4086

       

      9.2.  Choice
        of Law:
        The
        Parties agree that this Agreement shall be governed by the laws of the State
        of
        New York without reference to conflict of laws principles.

       

      9.3.  Entire
        Agreement:
        This
        Agreement, including all Exhibits attached hereto and all documents delivered
        concurrently herewith,. set forth all the licenses, covenants, premises,
        agreements, warranties, representations, conditions, and understandings between
        the Parties hereto and supersede all prior agreements and understandings
        between
        the Parties relating to the subject matter hereof. This Agreement, including,
        without limitation, the Exhibits attached hereto, is intended to describe
        the
        full extent of the legally enforceable undertakings of the Parties
        hereto.

       

      
        
           

        

        
          8

          
            

          

        

        
           

        

      

       

      9.4.  Severability:
        In the
        event that any provision of this Agreement shall, for any reason, be held
        to be
        invalid or unenforceable in any respect, such invalidity or unenforceability
        shall not affect any other provision hereof, and the Parties shall negotiate
        in
        good faith to modify the Agreement to preserve their original
        intent.

       

      9.5.  Amendment
        and Waiver:
        This
        Agreement may be amended, supplemented, or otherwise modified only be means
        of a
        written instrument signed by all Parties. Any waiver of any rights or failure
        to
        act in a specific instance shall relate only to such instances and shall
        not be
        construed as an agreement to waive any rights or fail to act in any other
        instance, whether or not similar.

       

      9.6.  Headings:
        The
        sections and paragraph headings contained herein are for the purposes of
        convenience only and are not intended to define or limit the contents of
        said
        sections or paragraphs.

       

      9.7.  Counterparts:
        This
        Agreement may be signed in counterpart, each of which shall be deemed to
        be an
        original. Signatures shall be provided by facsimile transmission, with original
        signatures following by mail.

       

      9.8.  Assignment:
        Neither
        this Agreement nor the licenses granted herein may be assigned to any Third
        Party. No Party shall assign, by operation of law or otherwise, any Licensed
        Patents to a Third Party without such Third Party agreeing to be bound in
        writing by the licenses granted hereunder.

       

      IN
        WITNESS WHEREOF, the undersigned Parties have duly executed and delivered
        this
        Agreement as of the date first written above.

       

      
        	
                Alliance
                  Pharmaceutical Corp.

                 

                By:
                  /s/
                  Lloyd A.
                  Rowland                             

                 

                Name:
                  Lloyd A. Rowland

                 

                Title:
                  Vice President & General Counsel

                 

                Date:
                  31 Jan 2001

                 

                 

                 

                Schering
                  Aktiengellschaft

                 

                By:/s/
                  H. G.
                  Rook                                      

                 

                Name:
                  H. G. Rook

                 

                Title:
                  Head of SBK, DG & RP

                 

                Date:
                  31.1.2001

                 

              	
                for
                  and on behalf of

                 

                Bracco
                  International B.V.

                 

                By:
                  Bracco Holding BV

                 

                Name:
                  Diana Bracco

                 

                Title:
                  Managing Director

                 

                Date:
                  31.01.01

                 

              

      

      

       

      
        
          
          

        

        
          9

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