Document:

EX-10.8

 Exhibit 10.8 

AMENDED AND RESTATED EMPLOYMENT AGREEMENT 

This Amended and Restated Employment Agreement (the “Agreement”), dated as of May 25, 2021 (the “Effective
Date”), is by and between Cyteir Therapeutics, Inc., a Delaware corporation (the “Company”) and Markus Renschler (the “Executive”). 

WHEREAS, the Company desires to continue to retain the services of the Executive, and the Executive wishes to continue to be employed by the
Company, on the terms and conditions set forth herein. 
 NOW, THEREFORE, for good and valuable consideration, the receipt and sufficiency
of which are hereby acknowledged, the parties agree as follows: 
 1.    Term. Effective as of the
Effective Date, the Executive will continue to be employed on an “at will” basis, and, subject to Section 5 of the Agreement, either the Executive or the Company may terminate the employment relationship at any time, with or without
cause, and with or without advance notice. 
 2.    Duties. The Executive will continue to serve as the
President and Chief Executive Officer of the Company and will continue to have such duties of an executive nature, consistent with such position, as the Board of Directors of the Company (the “Board”) shall determine from time to
time. The Executive will report to the Board. For so long as the Executive is employed by the Company as President and Chief Executive Officer, the Company will nominate the Executive to serve as a member of the Board at each annual meeting of the
Company’s stockholders at which the Executive’s then-current term expires and, if so elected at such meeting, the Executive will continue to serve as a member of the Board. Upon the termination of the Executive’s employment as
President and Chief Executive Officer, the Executive shall immediately resign from the Board as well as from any other position(s) to which the Executive was elected or appointed. The Executive will be an exempt, salaried full-time employee of the
Company, and will work substantially the majority of the Executive’s business time from the headquarters of the Company in Lexington, Massachusetts (or such other office as may from time to time be the headquarters of the Company). 

3.    Full Time; Best Efforts. The Executive shall diligently promote the interests of the Company and shall
devote the Executive’s full business time and best efforts to the performance of his duties and responsibilities hereunder. The Executive shall not engage in any other business or commercial activity; provided that, with the prior written
approval of the. Board, the Executive may serve on the boards of other entities. The Executive may engage in charitable or civic endeavors, so long as they do not interfere with the performance of the Executive’s duties and responsibilities
hereunder. 
 4.    Compensation and Benefits. During the Executive’s employment with the Company
under this Agreement, the Executive shall be entitled to compensation and benefits as follows: 
 (a)    Base
Salary. The Executive will receive a salary at the rate of $466,000 annually (as adjusted, from time to time, the “Base Salary”), payable in equal increments in accordance with the Company’s payroll policy. 

 (b)    Annual Bonus. For each fiscal year completed during
the Executive’s employment under this Agreement, the Executive will be eligible to earn an annual bonus (the “Annual Bonus”). The Executive’s target bonus will be forty percent (40%) of the Base Salary (as adjusted, from
time to time, the “Target Bonus”), with the actual amount of any such Annual Bonus to be determined by the Board or the Compensation Committee of the Board (the “Compensation Committee”) based upon
quantitative and qualitative performance objectives established by the Board or the Compensation Committee. The Board or the Compensation Committee shall determine in good faith the amount of the Annual Bonus earned, and such determination shall be
binding and conclusive. Any Annual Bonus will be paid within thirty (30) days following the determination of the Board or the Compensation Committee, as applicable. 

(c)    Equity Awards. The Executive will be eligible to participate in any plan or program under which the
Company provides equity-based awards, with any grants under such plans or programs to be determined in the sole discretion of the Board or the Compensation Committee, as applicable. 

(d)    Benefits. The Executive shall be entitled to participate in Company benefit plans that are generally
available to the Company’s executive employees in accordance with and subject to the then existing terms and conditions of such plans. 

(e)    Vacation. The Executive shall be entitled to twenty (20) days of paid vacation time per year, to
accrue on a pro-rated basis, in accordance with Company policies. 

(f)    Expenses. The Executive will be entitled to reimbursement of all reasonable expenses incurred in the
ordinary course of business on behalf of the Company, subject to the presentation of appropriate documentation and approved by, or in accordance with policies established by, the Board. 

(g)    Withholding. The Company may withhold from compensation payable to the Executive (both cash and
equity) all taxes and other amounts required to be withheld by the Company under applicable law. 

5.    Termination. 

(a)    General. The Executive’s employment with the Company may be terminated by the Company or the
Executive at any time, with or without cause, upon written notice to the other party. In the event of termination of the Executive’s employment with the Company, howsoever occurring, the Company shall pay the Executive (i) the Base Salary
for the final payroll period of his employment through the date his employment terminates; (ii) compensation at the rate of the Base Salary for any vacation time earned but not used as of the date his employment terminates; and
(iii) reimbursement, in accordance with Section 4(f) hereof, for business expenses incurred by the Executive but not yet paid to the Executive as of the date his employment terminates, provided that the Executive submits all expenses and
supporting documentation required within sixty (60) days of the date his employment terminates, and provided further that such expenses are reimbursable under Company policies then in effect (all of the foregoing, “Final
Compensation”). Except as otherwise provided in Section 5(a)(iii), Final Compensation will be paid to the Executive within thirty (30) days following the date of termination or such shorter period required by law. 

  
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 (b)    Effects of Termination. 

(i)    If the Executive’s employment is terminated by the Company without “Cause” or by the Executive for
“Good Reason” (each as defined below), then the Company shall pay to the Executive, in addition to Final Compensation, (i) the Base Salary for a period of twelve (12) months following the date of termination, payable in the form
of salary continuation, and (ii) provided that the Executive timely elects to continue his coverage and that of any eligible dependents in the Company’s group health plans under the federal law known as “COBRA” or similar state
law, a monthly amount equal to the monthly health premiums for such coverage paid by the Company on behalf of the Executive and any eligible dependents immediately prior to the date that the Executive’s employment terminates until the earlier
of (x) the date that is twelve (12) months following the date that the Executive’s employment terminates, (y) the date that the Executive and the Executive’s eligible dependents cease to be eligible for such COBRA coverage
under applicable law or plan terms and (z) the date on which the Executive obtains health coverage from another employer. Notwithstanding the foregoing, in the event that the Company’s payment of the amounts described under subsection
(ii) would subject the Company to any tax or penalty under the Patient Protection and Affordable Care Act (as amended from time to time, the “ACA”), or Section 105(h) of the Internal Revenue Code of 1986, as amended
(“Section 105(h)”), or applicable regulations or guidance issued under the ACA or Section 105(h), the Executive and the Company agree to work together in good faith, consistent with the requirements for
compliance with or exemption from Section 409A, to restructure such benefit. 
 (ii)    For purposes of this
Agreement, “Cause” means that the Executive has, as determined by the Board in its sole discretion, (A) breached any fiduciary duty, (B) breached any legal or contractual obligation to the Company or any of its affiliates,
(C) engaged in fraud, embezzlement, acts of dishonesty or a conflict of interest relating to the affairs of the Company or any of its affiliates, (D) been charged with, convicted of or plead nolo contendere to any felony or to any criminal
charge involving moral turpitude or that could reasonably be expected to have a material adverse effect on the business or affairs of the Company or any of its affiliates, (E) failed to comply with any material Company rule, policy or
procedure, (F) habitually used alcohol or drugs in a way that interferes with the Executive’s performance of the Executive’s duties, (G) committed any action that could reasonably be expected to cause the Company or any of its
affiliates public disgrace, disrepute or substantial economic harm, (H) entered into any consent decree with respect to a governmental authority that could reasonably be expected to have a material adverse effect on the business or affairs of
the Company or any of its affiliates, or (I) if the Board determines to terminate the Executive’s employment for persistent unsatisfactory performance or neglect of job duties, provided that the Executive is first given thirty
(30) days’ written notice to cure such unsatisfactory performance or neglect. 

  
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 (iii)    For purposes of this Agreement, “Good Reason”
shall exist if any of the following occurs without the Executive’s express consent: (A) a material breach of this Agreement by the Company, (B) a material reduction in the Executive’s duties, position or responsibilities, taken
as a whole, (C) a material reduction of the Base Salary and/or Target Bonus other than as part of a similar reduction for substantially all employees or substantially all senior officers, or (D) a relocation of the Executive’s
business office to another location more than fifty (50) miles away and outside the greater Boston/Cambridge area, provided such relocation also materially increases the Executive’s commuting distance, and provided that no relocation will
constitute Good Reason if the Executive is allowed to continue to provide services remotely (e.g., through telecommuting) at the time of the relocation. To resign for Good Reason, the Executive must give the Company written notice of the event or
act constituting Good Reason within sixty (60) days after its occurrence; the Company must be given thirty (30) days to cure such event or act; and, if the event or act is not cured by the Company, the Executive must resign within thirty
(30) days after the end of such cure period. 
 (c)    Conditions to Severance. The Company’s
obligation to pay the payments and benefits set forth in subsection (b) above or subsection (d) below (other than the Final Compensation) (and the Executive’s right to retain the Severance Benefits) shall be subject to each of the
following (the “Severance Conditions”): (a) continued compliance by the Executive with the non-disparagement obligations under Section 7 of the Agreement and the terms of the Employee
Obligations Agreements; (b) the Executive’s execution and non-revocation of a full general release of any claims against the Company, its affiliates, and their related persons, in a form requested by
the Company (provided the Executive shall not be required for release claims for indemnification, claims related to receipt of distributions or dividends as a shareholder, and any claims that cannot be waived as a matter of law) (the
“Release”), and provided that such Release becomes effective and irrevocable no later than sixty (60) days following the termination date or such earlier date required by the Release (the “Release Deadline”);
and (c) if requested by the Company, the Executive shall deliver to the Company in a timely manner (and execute and allow to become effective) and continue to comply with a one-year post-employment non-competition covenant that shall have been made in connection with the cessation of or separation from employment, and/or a
one-year post-employment covenant not to solicit (or assist others in soliciting) for employment or consulting positions any employees or substantially full-time consultants of the Company or its affiliates,
in either case in the form requested by the Company, if at all. For the avoidance of doubt, the Executive will forfeit any rights to the payments and benefits set forth in subsection (b) above or subsection (d) below (other than the Final
Compensation) if the Release does not become effective by the Release Deadline. 
 (d)    Termination after
Change in Control. 
 (i)    If the Executive’s employment is terminated by the Company without
“Cause” or by the Executive for “Good Reason”, in either case on or within twenty-four (24) months after a Change in Control (as defined below), and subject to completion of and continuing compliance with the Severance
Conditions, in lieu of the payments and benefits set forth in subsection (b) above, (i) the Company shall pay the Executive an amount equal to 1.5 multiplied by the sum of (x) the Base Salary and (y) the Target Bonus, payable in the
form of salary continuation for eighteen (18) months following the date that the Executive’s employment terminates and (ii) provided that the Executive timely elects to continue his coverage and that of any eligible dependents in the
Company’s group health plans under the federal law known as “COBRA” or similar state law, a monthly amount equal to the monthly health premiums for such coverage paid by the Company on behalf of the Executive and any eligible
dependents immediately prior to the date that the Executive’s employment terminates until the earlier of (x) the date that is eighteen (18) months following the date that the Executive’s employment terminates, (y) the date
that the Executive and the Executive’s eligible dependents cease to be eligible for such COBRA coverage under applicable law or plan terms and (z) the date on which the Executive obtains health coverage from another employer. 

  
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 (ii)    If the Executive’s employment is terminated by the Company
without “Cause” or by the Executive for “Good Reason”, in either case at any time on or following a Change in Control (as defined below), and subject to completion of and continuing compliance with the Severance Conditions, in
addition to the payments and benefits provided under subsection (b) or (d) above, as applicable, upon such termination of employment, the vesting and exercisability of all of the Executive’s stock options and other equity-based awards
there were outstanding as of the Change in Control will be accelerated in full (with any stock options and equity-based awards that are subject to performance-based vesting conditions vesting based on the greater of (x) the achievement of the
applicable performance goals at target and (y) the actual level of achievement of the applicable performance goals, as determined by the Board or the Compensation Committee, in its respective sole discretion, in either case, determined as if
any applicable service-based vesting requirement had been met) and the Executive’s stock options will remain exercisable until the termination date stated in the grant notice underlying such stock options. 

(iii)    For purposes of this agreement, “Change of Control” shall mean (x) a sale of all or
substantially all the assets of the Company, (y) a merger into or consolidation of the Company with any other corporation, except any such merger or consolidation involving the Company or a subsidiary of the Company in which the holders of
capital stock of the Company immediately prior to such a merger or consolidation continue to hold immediately following such merger or consolidation at least 50% by voting power of the capital stock of (1) the surviving or resulting corporation
or (2) if the surviving or resulting corporation is a wholly owned subsidiary of another corporation immediately following such merger or consolidation, the parent corporation of such surviving or resulting corporation, or (z) any
transaction or series of related transactions to which the Company is a party in which in excess of fifty percent (50%) of the Company’s voting stock is transferred, other than such a transaction completed primarily for equity financing
purposes. 
 (e)    Section 280G. If any payment or benefit that the Executive may receive, whether or not
payable or provided under this Agreement (“Payment”), would (i) constitute a “parachute payment” within the meaning of Section 280G of the Internal Revenue Code of 1986, as amended (the
“Code”), and (ii) but for this sentence, be subject to the excise tax imposed by Section 4999 of the Code (the “Excise Tax”), then such Payment shall be reduced to the Reduced
Amount. The “Reduced Amount” shall be either (A) the largest portion of the Payment that would result in no portion of the Payment being subject to the Excise Tax or (B) the largest portion, up to and
including the total amount, of the Payment, whichever of the amounts determined under (A) and (B), after taking into account all applicable federal, state and local employment taxes, income taxes, and the Excise Tax (all computed at the highest
applicable marginal rate), results in the Executive’s receipt, on an after-tax basis, of the greater amount of the Payment notwithstanding that all or some portion of the Payment may be subject to the
Excise Tax. If a reduction in payments or benefits constituting “parachute payments” is necessary so that the Payment equals the Reduced Amount, reduction shall occur in the following order: reduction of cash payments; reduction of
employee benefits; and cancellation of accelerated vesting of outstanding equity awards. In the event that acceleration of vesting of outstanding equity awards is to be reduced, such acceleration of vesting shall be undertaken in the reverse order
of the date of grant of the Executive’s outstanding equity awards. All calculations and determinations made pursuant this Section 5(e) will be made by an independent accounting or consulting firm or independent tax counsel appointed by the
Company (the “Tax Counsel”) whose determinations shall be conclusive and binding on the Company and the Executive for all purposes. For purposes of making the calculations and determinations required by this
Section 5(e), the Tax Counsel may rely on reasonable, good faith assumptions and approximations concerning the application of Section 280G of the Code and Section 4999 of the Code. The Company shall bear all costs the Tax Counsel may
reasonably incur in connection with its services. 

  
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 (f)    Survival. The provisions of Sections 5 through 20
of this Agreement shall survive the termination of this Agreement and the termination of the Executive’s employment with the Company, and shall continue thereafter in full force and effect in accordance with their terms. 

6.    Employee Obligations Agreements. Nothing in this Agreement amends or alters the Nondisclosure,
Inventions and Nonsolicitation Agreement by and between the Executive and the Company, dated as of September 26, 2018 or the Non-Competition Agreement by and between the Executive and the Company,
effective as of December 5, 2018 (together, the “Employee Obligations Agreements”). 

7.    Nondisparagement. During the Executive’s employment with the Company and at all times thereafter,
the Executive will not, directly or indirectly, make any disparaging statement, written or oral, about the Company or any of its predecessors or affiliates, or any of their directors, officers, employees, owners, stockholders, managers, agents,
attorneys or representatives. This Section shall not, however, prohibit the Executive from providing truthful information to any governmental agency or court, or from testifying truthfully as a witness in any court proceeding or governmental
investigation. 
 8.    Section 409A. This Agreement is intended to comply with or be exempt from the
requirements of Section 409A of the Code and the regulations thereunder. To the extent that any provision in this Agreement is ambiguous as to its compliance with, or exemption from, Section 409A of the Code, the provision shall be
interpreted (to the extent practicable) in a manner so that no payment due to the Executive shall be subject to an “additional tax” within the meaning of Section 409A(a)(l)(B) of the Code; provided, however, that nothing contained in
this Agreement or otherwise shall constitute a representation that any payment due to the Executive is not subject to the additional tax nor constitute a covenant to compensate or reimburse the Executive for any additional taxes. In no event shall
the Company or any of its affiliates have any liability relating to the failure or alleged failure of any payment or benefit under this Agreement to comply with, or be exempt from, the requirements of Section 409A of the Code. 

  
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 Notwithstanding anything to the contrary in this Agreement, if at the time the
Executive’s employment terminates, he is a “specified employee,” as defined below, any and all amounts payable under Sections 5(b)(i) or 5(d)(i) of this Agreement on account of such separation from service that would (but for this
provision) be payable within six (6) months following the date of termination, shall instead be paid on the next business day following the expiration of such six (6) month period or, if earlier, upon the Executive’s death; except
(A) to the extent of amounts that do not constitute a deferral of compensation within the meaning of Treasury regulation Section 1.409A-1(b) (including without limitation by reason of the safe harbor
set forth in Section 1.409A-1(b)(9)(iii), as determined by the Company in its reasonable good faith discretion); (B) benefits which qualify as excepted welfare benefits pursuant to Treasury regulation Section 1.409A-1(a)(5); or (C) other amounts or benefits that are not subject to the requirements of Section 409A of the Code. For purposes of this Agreement, all references to “termination of
employment” and correlative phrases shall be construed to require a “separation from service” (as defined in Section 1.409A-1(h) of the Treasury regulations after giving effect to the
presumptions contained therein), to the extent required to avoid adverse tax consequences under Section 409A of the Code, and the term “specified employee” means an individual determined by the Company to be a specified employee under
Treasury regulation Section 1.409A-1(i). 
 For purposes of Section 409A of the Code, each
payment made under this Agreement shall be treated as a separate payment for purposes of Treasury Regulation Section 1.409A-2(b)(2). In no event may the Executive, directly or indirectly, designate the
calendar year of any payment. If any payments or benefits under Sections 5(b)(i) or 5(d)(i), constitute “non-qualified deferred compensation” under Section 409A of the Code, and the period to
execute the Release described in Section 5(c) commences in one calendar year and ends in another calendar year, then regardless of when the Release is returned to the Company and becomes effective, the severance payments and benefits shall not
commence until the later calendar year. All reimbursements provided under this Agreement shall be made or provided in accordance with the requirements of Section 409A of the Code, including, where applicable, the requirement that (i) any
reimbursement be for expenses incurred during the Executive’s, (ii) the amount of expenses eligible for reimbursement during a calendar year may not affect the expenses eligible for reimbursement in any other calendar year, (iii) the
reimbursement of an eligible expense will be made on or before the last day of the calendar year following the year in which the expense is incurred, and (iv) the right to reimbursement is not subject to liquidation or exchange for another
benefit. 
 9.    Enforceability. This Agreement shall be interpreted in such a manner as to be effective
and valid under applicable law, but if any provision hereof shall be prohibited or invalid under any such law, such provision shall be ineffective to the extent of such prohibition or invalidity, without invalidating or nullifying the remainder of
such provision or any other provisions of this Agreement. If any one or more of the provisions contained in this Agreement shall for any reason be held to be excessively broad as to duration, geographical scope, activity or subject, such provisions
shall be construed by limiting and reducing it so as to be enforceable to the maximum extent permitted by applicable law. 

10.    Notices. All notices, demands or other communications hereunder shall be in writing and shall be
deemed to have been duly given if delivered in person, by e-mail or fax, by United States mail, certified or registered with return receipt requested, or by a nationally recognized overnight courier service,
or otherwise actually delivered: (a) if to the Executive: to his last address on file with the Company; (b) if to the Company, 128 Spring St., Building A Suite 510, Lexington, MA 02421, Attn: Chairman of the Board; or (c) or at such
other address as may have been furnished by such person in writing to the other parties. Any such notice, demand or communication shall be deemed given on the date given, if delivered in person, e-mailed or faxed, on the date received, if given by
registered or certified mail, return receipt requested or given by overnight delivery service, or three days after the date mailed, if otherwise given by first class mail, postage prepaid. 

  
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 11.    Governing Law; Consent to Jurisdiction. This
Agreement shall be governed by and construed in accordance with the internal laws of the Commonwealth of Massachusetts, without regard to its choice of law provisions. Any proceeding arising out of or relating to this Agreement shall be brought
exclusively in the courts of the Commonwealth of Massachusetts, or, if it has or can acquire jurisdiction, in the United States District Court for the District of Massachusetts. This provision may be filed with any court as written evidence of the
knowing and voluntary irrevocable agreement between parties to waive any objections to jurisdiction, venue or convenience of forum. 

12.    Agreement to Arbitrate Employment-Related Claims. Except as otherwise limited, all disputes arising
out of this Agreement and all other employment-related legal disputes, controversies or claims arising out of, or relating to, employment or cessation of employment, whether arising under federal, state or local decisional or statutory law
(“Employment-Related Claims”), shall be settled exclusively by final and binding arbitration. Arbitration is administered by the American Arbitration Association (“AAA”) under the employment arbitration portion of
the AAA’s Employment Arbitration Rules and Mediation Procedures. Arbitration is held before a neutral, third-party Arbitrator. Merely by way of example, Employment-Related Claims include, but are not limited to, claims arising under the Age
Discrimination in Employment Act (ADEA), Title VII of the Civil Rights Act of 1964, the Americans with Disabilities Act (ADA), the Family and Medical Leave Act (FMLA), the Fair Labor Standards Act (FSLA), 42 U.S.C. § 198, state discrimination
statutes, state statutes, and/or common law regulating employment termination, misappropriation, breach of the duty of loyalty, the law of contract or the law of tort; including, but not limited to, claims for malicious prosecution, wrongful
discharge, wrongful arrest/ wrongful imprisonment, intentional/negligent infliction of emotional distress or defamation. 

13.    Amendments and Waivers. This Agreement may be amended or modified only by a written instrument signed
by the Company and the Executive. No waiver of this Agreement or any provision hereof shall be binding upon the party against whom enforcement of such waiver is sought unless it is made in writing and signed by or on behalf of such party. 

14.    No Waivers. The waiver of a breach of any provision of this Agreement shall not be construed as a
waiver or a continuing waiver of the same or any subsequent breach of any provision of this Agreement. No delay or omission in exercising any right under this Agreement shall operate as a waiver of that or any other right. 

15.    Binding Effect. This Agreement shall be binding on and inure to the benefit of the parties hereto and
their respective heirs, executors and administrators, successors and assigns, except that the rights and obligations of the Executive hereunder are personal and may not be assigned without the Company’s prior written consent. Any assignment of
this Agreement by the Company, which shall not require consent of the Executive, shall not be considered a termination of the Executive’s employment. This Agreement shall continue to be binding and enforceable in full notwithstanding any
changes that may occur in the terms or conditions of the Executive’s employment with the Company. 

  
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 16.    Entire Agreement. This Agreement, along with the
Employee Obligations Agreements, constitutes the final and entire agreement of the parties with respect to the matters covered hereby and replaces and supersedes all other agreements and understandings related hereto and to the Executive’s
employment, including without limitation the Employment Agreement by and between the Executive and the Company, entered into as of November 10, 2017 and amended as of February 14, 2018 and October 1, 2018. 

17.    Counterparts. This Agreement may be executed in any number of counterparts, including counterpart
signature pages or counterpart facsimile signature pages, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. 

18.    No Conflicting Agreements. The Executive represents and warrants to the Company that the Executive is
not a party to or bound by any confidentiality, non-competition, non-solicitation, employment, consulting or other agreement or restriction that could conflict with, or
be violated by, the performance of the Executive’s duties to the Company or obligations under this Agreement. The Executive will not use or misappropriate any intellectual property, trade secrets or confidential information belonging to former
employers or to any other person or entity with whom the Executive has or had an agreement or to whom he owes a duty to keep such information in confidence. 

19.    Interpretation. The captions of the sections of this Agreement are for convenience of reference only
and in no way define, limit or affect the scope or substance of any section of this Agreement. The parties have participated jointly in the negotiation and drafting of this Agreement. In the event an ambiguity or question of intent or interpretation
arises under any provision of this Agreement, this Agreement shall be construed as if drafted jointly by the parties thereto, and no presumption or burden of proof shall arise favoring or disfavoring any party by virtue of authoring any of the
provisions of this Agreement. 
 20.    Key Man Insurance. The Executive acknowledges that the Company may
wish to purchase insurance on the life of the Executive, the proceeds of which would be payable to the Company or an affiliate of the Company. The Executive hereby consents to such insurance and agrees to submit to any medical examination and
release of medical records required to obtain such insurance. 
 [Remainder of Page Intentionally Left Blank] 

  
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 This Employment Agreement has been executed and delivered as a sealed instrument as of the
date first above written. 
  

			
	CYTEIR THERAPEUTICS, INC.
		
	By:	 	/s/ Joe Zakrzewski
	Name:	 	Joe Zakrzewski
	Title:	 	Chairman, Board of Directors, Cyteir

 
			
	
	 /s/ Markus Renschler

	Markus Renschler

 [Signature Page to Employment Agreement]EX-10.9

 Exhibit 10.9 

AMENDED AND RESTATED EMPLOYMENT AGREEMENT 

This AMENDED AND RESTATED EMPLOYMENT AGREEMENT (this “Agreement”) is made and entered into as of May 25, 2021 (the
“Effective Date”) by and between Cyteir Therapeutics, Inc. (the “Company”) and Andrew Gengos (the “Executive”). 

WHEREAS, the Executive possesses certain experience and expertise that qualifies him to provide the direction and leadership required by the
Company; and 
 WHEREAS, the Company desires to continue to employ the Executive as Chief Business Officer of the Company, and the Executive
wishes to continue to be employed by the Company, on the terms and conditions set forth herein. 
 NOW, THEREFORE, in consideration of the
mutual covenants contained herein and intending to be legally bound hereby, the Company and the Executive agree as follows: 

1.    Position and Duties. 

(a)    Effective as of the Effective Date, the Executive will continue to be employed by the Company, on a full-time
basis, as its Chief Business Officer. In addition, the Executive will serve from time to time if requested as a director or officer of one or more of the Company’s Affiliates, without further compensation. 

(b)    The Executive agrees to perform the duties of his position and such other duties as may reasonably be assigned to
the Executive from time to time. The Executive also agrees that, while employed by the Company, he will devote his full business time and his best efforts, business judgment, skill and knowledge exclusively to the advancement of the business
interests of the Company and its Affiliates and to the discharge of his duties and responsibilities for them. Notwithstanding the foregoing, the Executive may serve on the board of directors or similar governing body of other organizations with the
prior written approval of the Board of Directors of the Company (the “Board”) or Chief Executive Officer (such approval not to be unreasonably conditioned or withheld); provided, that (i) the Executive does not serve on
more than two (2) other boards of directors or similar governing bodies and (ii) such activities do not, individually or in the aggregate, interfere with the Executive’s performance of the Executive’ s duties to the Company as
provided in this Agreement, pose a conflict of interest, or otherwise violate any of the Executive’s obligations under this Agreement. 

(c)    The Executive agrees that, while employed by the Company, he will comply with all Company policies, practices and
procedures and all codes of ethics or business conduct applicable to his position, as in effect from time to time. 

2.    Compensation and Benefits. During the Executive’s employment hereunder, as compensation for all services
performed by the Executive for the Company and its Affiliates, the Company will provide the Executive the following compensation and benefits: 

(a)    Base Salary. The Company will pay the Executive a base salary at the rate of $388,000 per year, payable in
accordance with the regular payroll practices of the Company and subject to adjustment from time to time by the Company in its discretion (as adjusted, from time to time, the “Base Salary”). 

 (b)    Bonus Compensation. For each fiscal year completed during
the Executive’s employment under this Agreement, the Executive will be eligible to earn an annual bonus (each, an “Annual Bonus”). The Executive’s target bonus will be thirty-five percent (35%) of the Base Salary (as
adjusted, from time to time, the “Target Bonus”), with the actual amount of any such Annual Bonus to be determined by the Board or the Compensation Committee of the Board (the “Compensation Committee”) in its
discretion, based on the Executive’s performance and the Company’s performance against goals established by the Board or the Compensation Committee. In order to receive any Annual Bonus hereunder, the Executive must be employed through the
date that such Annual Bonus is paid. 
 (c)    Equity Awards. The Executive acknowledges that he was granted an
option to purchase 940,000 shares of the Company’s common stock (the “Option”) in connection with his commencement of employment, which Option is subject to the Company’s equity incentive plan, an award agreement and any
applicable shareholders agreement. The Executive will be eligible to participate in any plan or program under which the Company provides equity-based awards, with any grants under such plans or programs to be determined in the sole discretion of the
Board or the Compensation Committee, as applicable. 
 (d)    Signing Bonus. The Executive was paid a one-time bonus of $25,000 (the “Signing Bonus”) in connection with this commencement of employment. The Signing Bonus will be earned on February 24, 2022. If the Executive’s employment is
terminated by the Company for Cause or as a result of the Executive’s resignation without Good Reason, in either case prior to February 24, 2022, the Executive agrees to repay the full amount of the Signing Bonus to the Company within
thirty (30) days following the date of termination. 
 (e)    Participation in Employee Benefit Plans. The
Executive will be eligible to participate in all employee benefit plans from time to time in effect for employees of the Company generally, except to the extent such plans are duplicative of benefits otherwise provided to the Executive under this
Agreement (e.g., a severance pay plan). The Executive’s participation will be subject to the terms of the applicable plan documents and generally applicable Company policies, as the same may be in effect from time to time, and any other
restrictions or limitations imposed by law. 
 (f)    Vacations. The Executive will be entitled to earn vacation
days in accordance with the policies of the Company, as in effect from time to time. Vacation may be taken at such times and intervals as the Executive shall determine, subject to the business needs of the Company. 

(g)    Business Expenses. The Company will pay or reimburse the Executive for all reasonable business expenses
incurred or paid by the Executive in the performance of his duties and responsibilities for the Company, subject to any maximum annual limit and other restrictions on such expenses set by the Company and to such reasonable substantiation and
documentation as may be specified by the Company from time to time. The Executive’s right to payment or reimbursement hereunder shall be subject to the following additional rules: (i) the amount of expenses eligible for payment or
reimbursement during any calendar year shall not affect the expenses eligible for payment or reimbursement in any other calendar year, (ii) payment or reimbursement shall be made not later than December 31 of the calendar year following
the calendar year in which the expense or payment was incurred and (iii) the right to payment or reimbursement shall not be subject to liquidation or exchange for any other benefit. 

  
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 3.    Confidential Information and Restricted Activities. The
Executive acknowledges the importance to the Company and its Affiliates of protecting their confidential information and other legitimate business interests, including without limitation the valuable trade secrets and good will that it or they have
developed or acquired. Therefore, in consideration of the Executive’s continued employment with the Company, including the compensation to be paid to him and his being granted access to the good will, Confidential Information (as defined
below), trade secrets and other legitimate interests of the Company and its Affiliates, and in consideration of his receipt of the Option, the Executive agrees as follows: 

(a)    Confidential Information. During the course of the Executive’s employment with the Company, the
Executive has learned and will continue to learn of Confidential Information, and has developed and will continue to develop Confidential Information on behalf of the Company and its Affiliates. The Executive agrees that he will not use or disclose
to any Person (except as required by applicable law or for the proper performance of his regular duties and responsibilities for the Company) any Confidential Information obtained by the Executive incident to his employment or any other association
with the Company or any of its Affiliates. The Executive agrees that this restriction will continue to apply after his employment terminates, regardless of the reason for such termination. For the avoidance of doubt, (i) nothing contained in
this Agreement limits, restricts or in any other way affects the Executive’s communicating with any governmental agency or entity, or communicating with any official or staff person of a governmental agency or entity, concerning matters
relevant to such governmental agency or entity and (ii) the Executive will not be held criminally or civilly liable under any federal or state trade secret law for disclosing a trade secret (y) in confidence to a federal, state, or local
government official, either directly or indirectly, or to an attorney, solely for the purpose of reporting or investigating a suspected violation of law, or (z) in a complaint or other document filed under seal in a lawsuit or other proceeding;
provided, however, that notwithstanding this immunity from liability, the Executive may be held liable if he unlawfully accesses trade secrets by unauthorized means. 

(b)    Protection of Documents. All documents, records and files, in any media of whatever kind and description,
relating to the business, present or otherwise, of the Company or any of its Affiliates, and any copies, in whole or in part, thereof (the “Documents”), whether or not prepared by the Executive, shall be the sole and exclusive
property of the Company. The Executive agrees to safeguard all Documents and to surrender to the Company, at the time his employment terminates or at such earlier time or times as the Board or its designee may specify, all Documents then in his
possession or control. The Executive also agrees to disclose to the Company, at the time his employment terminates or at such earlier time or times as the Board or its designee may specify, all passwords necessary or desirable to obtain access to,
or that would assist in obtaining access to, any information which the Executive has password-protected on any computer equipment, network or system of the Company or any of its Affiliates. 

  
 -3- 

 (c)    Assignment of Rights to Intellectual Property. The
Executive shall promptly and fully disclose all Intellectual Property to the Company. The Executive hereby assigns and agrees to assign to the Company (or as otherwise directed by the Company) his full right, title and interest in and to all
Intellectual Property. The Executive agrees to execute any and all applications for domestic and foreign patents, copyrights or other proprietary rights and to do such other acts (including without limitation the execution and delivery of
instruments of further assurance or confirmation) requested by the Company to assign the Intellectual Property to the Company (or as otherwise directed by the Company) and to permit the Company to enforce any patents, copyrights or other proprietary
rights to the Intellectual Property. The Executive will not charge the Company or any of its Affiliates for time spent in complying with these obligations. All copyrightable works that the Executive creates during his employment shall be considered
“work made for hire” and shall, upon creation, be owned exclusively by the Company. 
 (d)    Restricted
Activities. The Executive agrees that the following restrictions on his activities during his employment are necessary to protect the goodwill, Confidential Information, trade secrets and other legitimate interests of the Company and its
Affiliates: 
 (i)    While the Executive is employed by the Company and during the twelve (12)-month period
immediately following termination of his employment, other than a termination due to layoff or termination by the Company without Cause (in the aggregate, the “Non-Compete Period”), the
Executive will not, directly or indirectly, whether as owner, partner, investor, consultant, agent, employee, co-venturer or otherwise, engage in any Competing Business (as defined below) in any geographic
area in which the Company or any of its Affiliates does business or is actively planning to do business during the Executive’s employment or, with respect to the portion of the Non-Compete Period that
follows the termination of the Executive’s employment, at the time of such termination, in any geographic area in which the Executive, during the last two (2) years of the Executive’s employment with the Company, provided services or
had a material presence or influence (the “Restricted Area”) or undertake any planning for any Competing Business in the Restricted Area, in each case involving any of the services that the Executive provided to the Company at any
time during the Executive’s employment with the Company or, with respect to the portion of the Non-Compete Period that follows the termination of the his employment, during the last two (2) years of
the Executive’s employment with the Company. As used herein, “Competing Business” refers to any Person that engages in any business that is directly competitive with the Company’s business of developing human therapeutics
utilizing a DNA Damage Repair mechanism, including any business or enterprise that develops, manufactures, markets, licenses, sells or provides any product or service that directly competes with any product or service developed, manufactured,
marketed, licensed, sold or provided by the Company during the Executive’s employment with the Company. 

(ii)    While the Executive is employed by the Company and during the twelve (12)-month period immediately following
termination of the Executive’s employment for any reason (in the aggregate, the “Non-Solicit Period”), the Executive will not, directly or indirectly, (a) solicit or encourage any
customer, vendor, supplier or other business partner of the Company or any of its Affiliates to terminate or diminish his, her or its relationship with any of them or (b) seek to persuade any such customer, vendor, supplier or other business
partner, or any prospective customer, vendor, supplier, or other business partner of the Company or any of its Affiliates, to conduct with anyone else any business or activity which such business partner or prospective business partner conducts or
could conduct with the Company or any of its Affiliates; provided, however, that these restrictions shall apply (y) only with respect to those Persons who are or have been a business partner of the Company or any of its Affiliates
at any time within the twenty-four (24)-month period immediately preceding the activity restricted by this Section 3(d)(ii) or whose business has been solicited on behalf of the Company or any of its Affiliates by any of their officers,
employees or agents within such twenty-four (24)-month period, other than by form letter, blanket mailing or published advertisement, and (z) only if the Executive has performed work for such Person during his employment with the Company or any
of its Affiliates or been introduced to, or otherwise had contact with, such Person as a result of his employment or other associations with the Company or one of its Affiliates or has had access to Confidential Information which would assist in his
solicitation of such Person. 

  
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 (iii)    During the Non-Solicit
Period, the Executive will not, directly or indirectly, (a) hire or engage, or solicit for hiring or engagement, any employee of the Company or any of its Affiliates or seek to persuade any such employee to discontinue employment or
(b) solicit or encourage any independent contractor providing services to the Company or any of its Affiliates to terminate or diminish his, her or its relationship with any of them. For the purposes of this Section 3(d)(iii), an
“employee” or an “independent contractor” of the Company or any of its Affiliates is any Person who was such at any time during the twenty-four (24)-month period immediately preceding the activity restricted by this
Section 3(d)(iii). 
 (e)    Subject to Section 3(a)(i), while the Executive is employed by the Company and at
all times following termination of his employment, regardless of the reason therefor, the Executive will not disparage or criticize the Company, its Affiliates, their business, their management or their products or services, and will not otherwise
do or say anything that could disrupt the good morale of employees of the Company or any of its Affiliates or harm the interests or reputation of the Company or any of its Affiliates. The Company agrees to (A) instruct its directors and senior
executives, and the directors and senior executives of its Affiliates, not to, whether in writing or orally, disparage the Executive and (B) not to disparage the Executive in authorized corporate communications to third parties; provided
that nothing herein shall or shall be construed or interpreted to prevent or impair the Company or its Affiliates or their respective directors and senior executives from (x) making public comments, such as in media interviews, which include
good faith, candid discussions or acknowledgments regarding the Company’s or any of its Affiliates’ performance or business, or (y) discussing the Executive in connection with performance evaluations, including impromptu evaluations
and feedback and good faith criticism. Notwithstanding the foregoing, nothing herein shall prevent either the Executive or any of the Company’s directors and senior executives from testifying truthfully in any legal or administrative proceeding
where such testimony is compelled or requested, or from otherwise complying with applicable legal requirements. 

(f)    In signing this Agreement, the Executive gives the Company assurance that the Executive has carefully read and
considered all the terms and conditions of this Agreement, including the restraints imposed on the Executive under this Section 3. The Executive agrees without reservation that these restraints are necessary for the reasonable and proper
protection of the Company and its Affiliates, and that each and every one of the restraints is reasonable in respect to subject matter, length of time and geographic area. The Executive further agrees that, were the Executive to breach any of the
covenants contained in this Section 3, the damage to the Company and its Affiliates would be irreparable. The Executive therefore agrees that the Company, in addition and not in the alternative to any other remedies available to it, shall be
entitled to preliminary and permanent injunctive relief against any breach or threatened breach by the Executive of any such covenants, without having to post bond, together with an award of its reasonable attorneys’ fees incurred in enforcing
its rights hereunder. The Executive further agrees that the Non-Solicit Period shall be tolled, and shall not run, during the period of any breach by the Executive of any of the covenants contained in this
Section 3. If the Executive violates any fiduciary duty to the Company or unlawfully takes any confidential or proprietary information or other property belonging to the Company, the Non-Compete Period
will extend by the time during which he engages in such violation(s), for up to a total of two (2) years following the termination of his employment. The Executive and the Company further agree that, in the event that any provision of this
Section 3 is determined by any court of competent jurisdiction to be unenforceable by reason of its being extended over too great a time, too large a geographic area or too great a range of activities, that provision shall be deemed to be
modified to permit its enforcement to the maximum extent permitted by law. It is also agreed that each of the Company’s Affiliates shall have the right to enforce all of the Executive’s obligations to that Affiliate under this Agreement,
including without limitation pursuant to this Section 3. No claimed breach of this Agreement or other violation of law attributed to the Company or any of its Affiliates, or change in the nature or scope of the Executive’s employment or
other relationship with the Company or any of its Affiliates, shall operate to excuse the Executive from the performance of his obligations under this Section 3. 

  
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 4.    Termination of Employment. The Executive’s employment
under this Agreement shall continue until terminated pursuant to this Section 4. 
 (a)    By the Company For
Cause. The Company may terminate the Executive’s employment for Cause upon notice to the Executive setting forth in reasonable detail the nature of the Cause. For purposes of this Agreement, “Cause” shall mean that the
Executive has, as determined by the Board in its sole discretion, (i) breached any fiduciary duty; (ii) materially breached any legal or contractual obligation to the Company or any of its Affiliates; (iii) engaged in fraud,
embezzlement, acts of dishonesty or a conflict of interest relating to the affairs of the Company or any of its Affiliates; (iv) been charged with, convicted of or plead nolo contendere to any felony or to any criminal charge involving moral
turpitude or that could reasonably be expected to have a material adverse effect on the business or affairs of the Company or any of its Affiliates; (v) failed to comply with any material Company rule, policy or procedure; (vi) habitually
used alcohol or drugs in a way that interferes with the Executive’s performance of the Executive’s duties; (vii) committed any action that could reasonably be expected to cause the Company or any of its Affiliates public disgrace,
disrepute or substantial economic harm; (viii) entered into a consent decree with respect to a governmental authority that could reasonably be expected to have a material adverse effect on the business or affairs of the Company or any of its
Affiliates; or (ix) exhibited persistent unsatisfactory performance or neglect of his job duties, provided that the Executive is first given thirty (30) days’ written notice to cure such unsatisfactory performance or neglect.
In addition, solely for purposes of Section 3(d)(i) of this Agreement and in addition to the foregoing, Cause shall also include (x) the Board’s good faith determination that it has a reasonable basis for dissatisfaction with the
Executive’s employment for reasons such as lack of capacity or diligence, failure to conform to usual standards of conduct, or other culpable or inappropriate behavior or (xi) other grounds for discharge that are reasonably related, in the
Board’s good faith judgment, to the needs of the business of the Company or any of its Affiliates. 

  
 -6- 

 (b)    By the Company Without Cause. The Company may terminate
the Executive’s employment at any time other than for Cause upon notice to the Executive. 
 (c)    By the
Executive for Good Reason. The Executive may terminate his employment for Good Reason, provided that (i) the Executive provides written notice to the Company, setting forth in reasonable detail the nature of the condition giving rise to
Good Reason, within thirty (30) days of the initial existence of such condition, (ii) the condition remains uncured by the Company for a period of thirty (30) days following such notice and (iii) the Executive terminates his
employment, if at all, not later than thirty (30) days after the expiration of such cure period. For purposes of this Agreement, “Good Reason” shall mean the occurrence of any of the following without the Executive’s
consent: (A) a material reduction in the Executive’s duties and responsibilities, taken as a whole; (B) a material reduction of the Executive’s Base Salary or Target Bonus other than as part of a similar reduction for
substantially all employees or substantially all senior officers; (C) the Company’s relocation of the Executive’s primary place of work by more than fifty (50) miles, provided such relocation also materially increases the
Executive’s commuting distance and provided that no relocation will constitute Good Reason if the Executive is allowed to provide services remotely (e.g., through telecommuting) at the time of the relocation; or (D) a material breach of
this Agreement by the Company. 
 (d)    By the Executive Without Good Reason. The Executive may terminate his
employment without Good Reason at any time upon thirty (30) days’ notice to the Company. The Board may elect to waive such notice period or any portion thereof. 

(e)    Death and Disability. The Executive’s employment hereunder shall automatically terminate in the event
of the Executive’s death during employment. The Company may terminate the Executive’s employment, upon notice to the Executive, in the event that the Executive becomes disabled during his employment hereunder through any illness, injury,
accident or condition of either a physical or psychological nature and, as a result, is unable to perform substantially all of his duties and responsibilities hereunder (notwithstanding the provision of any reasonable accommodation) for a period of
ninety (90) days during any period of three hundred sixty-five (365) consecutive days. If any question shall arise as to whether the Executive is disabled to the extent that he is unable to perform substantially all of his duties and
responsibilities for the Company and its Affiliates, the Executive shall, at the Company’s request, submit to a medical examination by a physician selected by the Company to whom the Executive or the Executive’s guardian, if any, has no
reasonable objection to determine whether the Executive is so disabled, and such determination shall for purposes of this Agreement be conclusive of the issue. If such a question arises and the Executive fails to submit to the requested medical
examination, the Company’s good faith, reasonable determination of the issue shall be binding on the Executive. 

  
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 5.    Other Matters Related to Termination. 

(a)    Final Compensation. In the event of termination of the Executive’s employment with the Company,
howsoever occurring, the Company shall pay the Executive (i) the Base Salary for the final payroll period of his employment through the date his employment terminates; (ii) compensation at the rate of the Base Salary for any vacation time
earned but not used as of the date his employment terminates; and (iii) reimbursement, in accordance with Section 2(g) hereof, for business expenses incurred by the Executive but not yet paid to the Executive as of the date his employment
terminates, provided that the Executive submits all expenses and supporting documentation required within sixty (60) days of the date his employment terminates, and provided further that such expenses are reimbursable under Company policies
then in effect (all of the foregoing, “Final Compensation”). Except as otherwise provided in Section 5(a)(iii), Final Compensation will be paid to the Executive within thirty (30) days following the date of termination or
such shorter period required by law. 
 (b)    Severance Payments. In the event of any termination of the
Executive’s employment pursuant to Section 4(b) or 4(c) (and, for the avoidance of doubt, under circumstances which the Board in its sole discretion has determined would not constitute Cause under any of clauses (i) through (ix) of
Section 4(a)), the Company will pay the Executive, in addition to Final Compensation, (i) the Base Salary for a period of nine (9) months following the date of termination, payable in the form of salary continuation, and(ii) provided
that the Executive timely elects to continue his coverage and that of any eligible dependents in the Company’s group health plans under the federal law known as “COBRA” or similar state law, a monthly amount equal to the monthly
health premiums for such coverage paid by the Company on behalf of the Executive and any eligible dependents immediately prior to the date that the Executive’s employment terminates until the earlier of (x) the date that is nine
(9) months following the date that the Executive’s employment terminates, (y) the date that the Executive and the Executive’s eligible dependents cease to be eligible for such COBRA coverage under applicable law or plan terms and
(z) the date on which the Executive obtains health coverage from another employer. Notwithstanding the foregoing, in the event that the Company’s payment of the amounts described under subsection (ii) would subject the Company to any
tax or penalty under the Patient Protection and Affordable Care Act (as amended from time to time, the “ACA”), or Section 105(h) of the Internal Revenue Code of 1986, as amended
(“Section 105(h)”), or applicable regulations or guidance issued under the ACA or Section 105(h), the Executive and the Company agree to work together in good faith, consistent with the requirements for
compliance with or exemption from Section 409A, to restructure such benefit. 
 (c)    Conditions To And Timing
Of Severance Payments and Benefits. Any obligation of the Company to provide the Executive the payments and benefits set forth in subsection (b) above or subsection (d) below (other than the Final Compensation) is conditioned on his
signing and returning, without revoking, to the Company a timely and effective separation agreement containing a general release of claims, restrictive covenants substantially similar to those contained in Section 3 of this Agreement and other
customary terms in the form provided to the Executive by the Company at the time that the Executive’s employment terminates (the “Separation Agreement”). The Separation Agreement must become effective, if at all, by the
sixtieth (60th) calendar day following the date the Executive’s employment terminates. Any amounts to which the Executive is entitled pursuant to subsection (b)(i) or (ii) above or subsection (d)(i) or (ii) below will be payable in
accordance with the normal payroll practices of the Company. The first such payment will be made on the Company’s next regular payday following the expiration of sixty (60) calendar days from the date that the Executive’s employment
terminates, but will be retroactive to the day following such date of termination. 

  
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 (d)    Termination after Change in Control. 

(i)    In the event of any termination of the Executive’s employment pursuant to Section 4(b) or 4(c) (and, for
the avoidance of doubt, under circumstances which the Board in its sole discretion has determined would not constitute Cause under any of clauses (i) through (ix) of Section 4(a)) occurring on or within twelve (12) months after a
Change in Control (as defined below), and subject to completion of and continuing compliance with the conditions set forth in Section 5(c), in lieu of the payments and benefits set forth in subsection (b) above, (i) the Company shall pay
the Executive an amount equal to the sum of (x) the Base Salary and (y) the Target Bonus, payable in the form of salary continuation for twelve (12) months following the date that the Executive’s employment terminates and
(ii) provided that the Executive timely elects to continue his coverage and that of any eligible dependents in the Company’s group health plans under the federal law known as “COBRA” or similar state law, a monthly amount equal
to the monthly health premiums for such coverage paid by the Company on behalf of the Executive and any eligible dependents immediately prior to the date that the Executive’s employment terminates until the earlier of (x) the date that is
twelve (12) months following the date that the Executive’s employment terminates, (y) the date that the Executive and the Executive’s eligible dependents cease to be eligible for such COBRA coverage under applicable law or plan
terms and (z) the date on which the Executive obtains health coverage from another employer. 
 (ii)    In the
event of any termination of the Executive’s employment pursuant to Section 4(b) or 4(c) (and, for the avoidance of doubt, under circumstances which the Board in its sole discretion has determined would not constitute Cause under any of
clauses (i) through (ix) of Section 4(a)) occurring at any time on or following a Change in Control, and subject to completion of and continuing compliance with the conditions set forth in Section 5(c), in addition to the payments and
benefits provided in subsection (b) or (d)(i) above, as applicable, upon such termination of employment, the vesting and exercisability of all the Executive’s stock options and other equity-based awards that were outstanding as of the
Change in Control will be accelerated in full (with any stock options and equity-based awards that are subject to performance-based vesting conditions vesting based on the greater of (x) the achievement of the applicable performance goals at
target and (y) the actual level of achievement of the applicable performance goals, as determined by the Board or the Compensation Committee, in its respective sole discretion, in either case, determined as if any applicable service-based
vesting requirement had been met). 

  
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 (e)    Section 280G. If any payment or benefit that the Executive
may receive, whether or not payable or provided under this Agreement (“Payment”), would (i) constitute a “parachute payment” within the meaning of Section 280G of the Internal Revenue Code of 1986, as amended
(the “Code”), and (ii) but for this sentence, be subject to the excise tax imposed by Section 4999 of the Code (the “Excise Tax”), then such Payment shall be reduced to the Reduced Amount. The
“Reduced Amount” shall be either (A) the largest portion of the Payment that would result in no portion of the Payment being subject to the Excise Tax or (B) the largest portion, up to and including the total amount, of
the Payment, whichever of the amounts determined under (A) and (B), after taking into account all applicable federal, state and local employment taxes, income taxes, and the Excise Tax (all computed at the highest applicable marginal rate),
results in the Executive’s receipt, on an after-tax basis, of the greater amount of the Payment notwithstanding that all or some portion of the Payment may be subject to the Excise Tax. If a reduction in
payments or benefits constituting “parachute payments” is necessary so that the Payment equals the Reduced Amount, reduction shall occur in the following order: reduction of cash payments; reduction of employee benefits; and cancellation
of accelerated vesting of outstanding equity awards. In the event that acceleration of vesting of outstanding equity awards is to be reduced, such acceleration of vesting shall be undertaken in the reverse order of the date of grant of the
Executive’s outstanding equity awards. All calculations and determinations made pursuant this Section 5(e) will be made by an independent accounting or consulting firm or independent tax counsel appointed by the Company (the “Tax
Counsel”) whose determinations shall be conclusive and binding on the Company and the Executive for all purposes. For purposes of making the calculations and determinations required by this Section 5(e), the Tax Counsel may rely on
reasonable, good faith assumptions and approximations concerning the application of Section 280G of the Code and Section 4999 of the Code. The Company shall bear all costs the Tax Counsel may reasonably incur in connection with its
services. 
 (f)    Benefits Termination. Except for any right the Executive may have under the federal law known
as “COBRA” or other applicable law to continue participation in the Company’s group health and dental plans at his cost, the Executive’s participation in all employee benefit plans shall terminate in accordance with the
terms of the applicable benefit plans based on the date of termination of his employment, without regard to any continuation of the Base Salary or other payment to the Executive following termination of his employment, and the Executive shall not be
eligible to earn vacation or other paid time off following the termination of his employment. 
 (g)    Survival.
Provisions of this Agreement shall survive any termination of employment if so provided in this Agreement or if necessary or desirable to accomplish the purposes of other surviving provisions, including without limitation the Executive’s
obligations under Section 3 of this Agreement. The obligation of the Company to make payments or provide benefits to the Executive under Sections 5(b) and 5(d), and the Executive’s right to retain the same, are expressly conditioned upon
his continued full performance of his obligations under Section 3 of this Agreement. Upon termination by either the Executive or the Company, all rights, duties and obligations of the Executive and the Company to each other shall cease, except
as otherwise expressly provided in this Agreement. 
 6.    Timing of Payments and
Section 409A. 
 (a)    Notwithstanding anything to the contrary in this Agreement, if at the
time the Executive’s employment terminates, the Executive is a “specified employee,” as defined below, any and all amounts payable under this Agreement on account of such separation from service that would (but for this provision) be
payable within six (6) months following the date of termination, shall instead be paid on the next business day following the expiration of such six (6)-month period or, if earlier, upon the Executive’s death; except (A) to the extent
of amounts that do not constitute a deferral of compensation within the meaning of Treasury regulation Section 1.409A-1(b) (including without limitation by reason of the safe harbor set forth in Section 1.409A-1(b)(9)(iii), as determined by the Company in its reasonable good faith discretion); (B) benefits which qualify as excepted welfare benefits pursuant to Treasury regulation Section 1.409A-1(a)(5); or (C) other amounts or benefits that are not subject to the requirements of Section 409A of the Code (“Section 409A”). 

  
 -10- 

 (b)    For purposes of this Agreement, all references to
“termination of employment” and correlative phrases shall be construed to require a “separation from service” (as defined in Section 1.409A-1(h) of the Treasury regulations after
giving effect to the presumptions contained therein), and the term “specified employee” means an individual determined by the Company to be a specified employee under Treasury regulation
Section 1.409A-1(i). 
 (c)    Each payment made under this Agreement shall
be treated as a separate payment and the right to a series of installment payments under this Agreement is to be treated as a right to a series of separate payments. 

(d)    In no event shall the Company have any liability relating to the failure or alleged failure of any payment or
benefit under this Agreement to comply with, or be exempt from, the requirements of Section 409A. 

7.    Definitions. For purposes of this Agreement, the following definitions apply: 

“Affiliates” means all persons and entities directly or indirectly controlling, controlled by or under common control with
the Company, where control may be by management authority, equity interest or otherwise. 
 “Change of Control” shall mean
(i) a sale of all or substantially all the assets of the Company; (ii) a merger into or consolidation of the Company with any other corporation, except any such merger or consolidation involving the Company or a subsidiary of the Company
in which the holders of capital stock of the Company immediately prior to such a merger or consolidation continue to hold immediately following such merger or consolidation at least fifty percent (50%) by voting power of the capital stock of
(A) the surviving or resulting corporation or (B) if the surviving or resulting corporation is a wholly owned subsidiary of another corporation immediately following such merger or consolidation, the parent corporation of such surviving or
resulting corporation; or (iii) any transaction or series of related transactions to which the Company is a party in which in excess of fifty percent (50%) of the Company’s voting stock is transferred, other than such a transaction
completed primarily for equity financing purposes. 
 “Confidential Information” means any and all information of the
Company and its Affiliates that is not generally available to the public. Confidential Information also includes any information received by the Company or any of its Affiliates from any Person with any understanding, express or implied, that it
will not be disclosed. Confidential Information does not include information that enters the public domain, other than through the Executive’s breach of his obligations under this Agreement or any other agreement between the Executive and the
Company or any of its Affiliates. 

  
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 “Intellectual Property” means inventions, discoveries, developments,
methods, processes, compositions, works, concepts and ideas (whether or not patentable or copyrightable or constituting trade secrets) conceived, made, created, developed or reduced to practice by the Executive (whether alone or with others, whether
or not during normal business hours or on or off Company premises) during the Executive’s employment that relate either to the business of the Company or any of its Affiliates or to any prospective activity of the Company or any of its
Affiliates or that result from any work performed by the Executive for the Company or any of its Affiliates or that make use of Confidential Information or any of the equipment or facilities of the Company or any of its Affiliates. 

“Person” means an individual, a corporation, a limited liability company, an association, a partnership, an estate, a trust
or any other entity or organization, other than the Company or any of its Affiliates. 
 8.    Conflicting
Agreements. The Executive hereby represents and warrants that his signing of this Agreement and the performance of his obligations under it will not breach or be in conflict with any other agreement to which the Executive is a party or is bound,
and that the Executive is not now subject to any covenants against competition or similar covenants or any court order that could affect the performance of his obligations under this Agreement. The Executive agrees that the Executive will not
disclose to or use on behalf of the Company any confidential or proprietary information of a third party without that party’s consent. 

9.    Withholding. All payments made by the Company under this Agreement shall be reduced by any tax or other
amounts required to be withheld by the Company to the extent required by applicable law. 
 10.    Assignment.
Neither the Executive nor the Company may make any assignment of this Agreement or any interest in it, by operation of law or otherwise, without the prior written consent of the other; provided, however, the Company may assign its
rights and obligations under this Agreement without the Executive’s consent to one of its Affiliates or to any Person with whom the Company shall hereafter effect a reorganization, consolidate or merge, or to whom the Company shall hereafter
transfer all or substantially all of its properties or assets. This Agreement shall inure to the benefit of and be binding upon the Executive and the Company, and each of their respective successors, executors, administrators, heirs and permitted
assigns. 
 11.    Severability. If any portion or provision of this Agreement shall to any extent be declared
illegal or unenforceable by a court of competent jurisdiction, then the remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so declared illegal or unenforceable, shall not
be affected thereby, and each portion and provision of this Agreement shall be valid and enforceable to the fullest extent permitted by law. 

  
 -12- 

 12.    Agreement to Arbitrate. Any and all disputes,
controversies and/or claims between the Executive and the Company of any kind whatsoever (other than those involving Section 3 of this Agreement) shall be resolved through final and binding confidential arbitration administered by JAMS pursuant
to its Employment Arbitration Rules & Procedures before a single arbitrator who is a retired judge. Notwithstanding this agreement to arbitrate, the Executive and the Company agree that either party may seek provision remedies such as a
temporary restraining order or a preliminary injunction from a court of competent jurisdiction in aid of arbitration. This agreement to arbitrate shall include, without limitation, any and all disputes, controversies and/or claims against the
Company or any of its Affiliates or the current or former partners, members, officers or employees of the Company or any of its Affiliates, whether arising under theories of liability or damages based on contract, tort or statute, to the fullest
extent permitted by law. Such claims shall include, without limitation, claims for breach of contract or breach of the covenant of good faith and fair dealing, any claims of discrimination or other claims under Title VII of the Civil Rights Act of
1964, as amended, the Age Discrimination in Employment Act of 1967, the Americans with Disabilities Act, the Family and Medical Leave Act, the Fair Labor Standards Act, ERISA and/or any applicable or equivalent state or local laws, claims for
wrongful termination, including employment termination in violation of public policy, and claims for personal injury including, without limitation, defamation, fraud and infliction of emotional distress. This agreement to arbitrate also covers any
issues relating to the interpretation, applicability or enforceability of this Section 12. The only claims not covered by this agreement to arbitrate are claims for benefits under workers’ compensation or unemployment insurance statutes
and other claims that cannot be arbitrated as a matter of law. As a material part of this agreement to arbitrate claims, both the Executive and the Company expressly waive all rights to a jury trial in court on all statutory or other claims,
including, without limitation, those identified in this Section 12. The Executive also acknowledges and agrees that no claims will be arbitrated on a class action or collective action basis. Any arbitration hereunder shall take place in Boston,
Massachusetts. The Executive and the Company agree that any award of the arbitrator shall be final, conclusive and binding and that the Executive will not contest any action by any other party thereto in accordance with the award of the arbitrator.
It is specifically understood and agreed that any party hereto may enforce any award rendered pursuant to the arbitration by bringing suit in any court of competent jurisdiction. All reasonable fees, costs and expenses (including reasonable
attorneys’ fees, expenses and costs) incurred by the prevailing party in any arbitration will be borne by the other party. Any claim must be brought to arbitration within the statute of limitations for bringing such claim in court or before the
appropriate administrative agency, as applicable. 
 13.    Miscellaneous. This Agreement sets forth the entire
agreement between the Executive and the Company, and replaces all prior and contemporaneous communications, agreements and understandings, written or oral, with respect to the terms and conditions of the Executive’s employment, including,
without limitation, the Employment Agreement by and between the Executive and the Company, effective as of February 24, 2020 (it being understood that nothing in this Agreement will serve to amend the covenants contained in Section 3 of
such agreement, which survive by their terms and also are incorporated in this Agreement as Section 3 of this Agreement). This Agreement may not be modified or amended, and no breach shall be deemed to be waived, unless agreed to in writing by
the Executive and an expressly authorized representative of the Board. The headings and captions in this Agreement are for convenience only and in no way define or describe the scope or content of any provision of this Agreement. This Agreement may
be executed in two or more counterparts, each of which shall be an original and all of which together shall constitute one and the same instrument. This is a Massachusetts contract and shall be governed and construed in accordance with the laws of
the Commonwealth of Massachusetts, without regard to any conflict of laws principles that would result in the application of the laws of any other jurisdiction. 

  
 -13- 

 14.    Acknowledgment. The Executive acknowledges that the
(1) the Company provided him with this Agreement at least ten (10) business days before its Effective Date, (2) he has been and is hereby advised of his right to consult an attorney before signing this Agreement, and (3) he has
carefully read this Agreement and understands and agrees to all of the provisions in this Agreement. 

15.    Notices. Any notices provided for in this Agreement shall be in writing and shall be effective when
delivered in person or deposited in the United States mail, postage prepaid, and addressed to the Executive at his last known address on the books of the Company or, in the case of the Company, to it at its principal place of business, attention of
the Chairman of the Board, or to such other address as either party may specify by notice to the other actually received. 
 IN WITNESS
WHEREOF, this Agreement has been executed by the Company, by its duly authorized representative, and by the Executive, as of the date first above written. 
  

							
	THE EXECUTIVE:	 		 	THE COMPANY:
				
	/s/ Andrew Gengos	 		 	By:	 	/s/ Markus Renschler
	Andrew Gengos	 		 	Name:	 	Markus Renschler, MD
		 		 	Title:	 	President and CEO

  
 -14-

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