Document:

Exhibit 4.60
REDACTED
Certain identified information, indicated by [*****], has been excluded from the exhibit because it is both (i) not material and (ii) would likely cause competitive harm if publicly disclosed.
SECOND AMENDMENT TO 
SPONSORED RESEARCH AGREEMENT 
MEE Agreement No. 2019A009504.02
This second amendment to Agreement (the “Second Amendment”), is effective as of July 29, 2021 (“Second Amendment Effective Date”), by and between The Schepens Eye Research Institute, Inc., a not-for-profit Massachusetts corporation, having a principal place of business at 20 Staniford Street, Boston, Massachusetts 02114 (“SERI”), and Massachusetts Eye and Ear Infirmary, having a principal place of business at 243 Charles Street, Boston, Massachusetts 02114 (“MEEI”) (collectively, SERI and MEEI shall be referred to herein as “Hospitals”), and CureVac AG, a German stock corporation, having a principal place of business at Friedrich-Miescher-Straße 15, 72076 Tübingen, Germany (“Sponsor”), each herein referred to as a “Party” and collectively as the “Parties”.  Capitalized terms that are not defined herein shall have the meaning ascribed to them in the Agreement (as defined below).
RECITALS
WHEREAS, Hospitals and Sponsor are Parties to sponsored research agreement, MEE Agreement No. 2019A009504 (formerly, 2019-0112), effective as of March 15, 2019, as previously amended effective as of May 19, 2020 (the “Agreement”);
WHEREAS, the Parties desire to extend the Term until August 31, 2021; and
WHEREAS, Sponsor and Hospitals acknowledge that as of [*****], payments (a) through (d) described in Section 5.1 of the Agreement and totaling US [*****] have been paid in full; and
 In consideration of the promises made herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Hospitals and Sponsor hereby agree as follows:
1.AMENDMENT
1.1The Agreement is hereby amended by deleting Section 2 in its entirety and inserting the following language in its place:
“2. Term.  The term of this Agreement shall be from the Effective Date until August 31, 2021 (the “Term”), unless earlier terminated by either Party as set forth in Section 11 or extended in a writing signed by authorized representatives of both Parties.”
	1.2
	Except as herein provided, the Agreement and all of its terms, covenants and conditions are hereby ratified and confirmed in all respects and remain in full force and effect. The Agreement shall, together with this Second Amendment, be read and construed as a single agreement.

	1.3
	This Second Amendment may be executed in two or more counterparts, each of which will be deemed an original, but all of which together will constitute one and the same

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instrument. This Second Amendment may be executed electronically/digitally in compliance with the Massachusetts Uniform Electronic Transactions Act (MUETA) Mass. Gen. Laws ch. 110G and/or The Electronic Signatures In Global And National Commerce Act (ESIGN) 15 USC ch. 96. Persons signing this Second Amendment agree that, if used, electronic/digital signatures are intended to authenticate this writing and to have the same force and effect as the use of manual signatures.
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IN WITNESS WHEREOF, the parties have caused this Second Amendment to Agreement to be executed and delivered by their duly authorized representatives as of the Second Amendment Effective Date.
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	CUREVAC AG
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	THE SCHEPENS EYE RESEARCH INSTITUTE, INC.

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	By:
	/s/ Heike Wagenaar
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	By:
	/s/ Rebecca Listfield, Ph.D.

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	Name:
	Heike Wagenaar
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	Name:
	Rebecca Listfield ,Ph.D.

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	Title:
	Senior Legal Counsel
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	Title:
	Managing Director, Licensing

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	Date:
	August 2, 2021
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	Date:
	July 29, 2021

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	MASSACHUSETTS EYE AND EAR INFIRMARY

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	By:
	/s/ Dr. Igor Splawski
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	By:
	/s/ Rebecca Listfield, Ph.D.

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	Name:
	Dr. Igor Splawski
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	Name:
	Rebecca Listfield, Ph.D.

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	Title:
	Chief Scientific Officer
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	Title:
	Managing Director, Licensing

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	Date:
	August 8, 2021
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	Date:
	July 29, 2021

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	By:
	/s/ Pierre Kemula
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	Name:
	Pierre Kemula
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	Title:
	Chief Financial Officer
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	Date:
	August 9, 2021
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Exhibit 4.61
REDACTED
Certain identified information, indicated by [*****], has been excluded from the exhibit because it is both (i) not material and (ii) would likely cause competitive harm if publicly disclosed.
THIRD AMENDMENT TO
SPONSORED RESEARCH AGREEMENT
MEE Agreement No. 2019A009504.03
This third amendment to Agreement (the “Third Amendment”), is effective as of September 1, 2021 (“Third Amendment Effective Date”), by and between The Schepens Eye Research Institute, Inc., a not-for-profit Massachusetts corporation, having a principal place of business at 20 Staniford Street, Boston, Massachusetts 02114 (“SERI”), and Massachusetts Eye and Ear Infirmary, having a principal place of business at 243 Charles Street, Boston, Massachusetts 02114 (“MEEI”) (collectively, SERI and MEEI shall be referred to herein as “Hospitals”), and CureVac AG, a German stock corporation, having a principal place of business at Friedrich-Miescher-Straße 15, 72076 Tübingen, Germany (“Sponsor”), each herein referred to as a “Party” and collectively as the “Parties”. Capitalized terms that are not defined herein shall have the meaning ascribed to them in the Agreement (as defined below).
RECITALS
WHEREAS, Hospitals and Sponsor are Parties to sponsored research agreement, MEE Agreement No. 2019A009504 (formerly, 2019-0112), effective as of March 15, 2019, as previously amended effective as of May 19, 2020 and July 29, 2021 (the "Agreement");
Sponsor and Hospitals acknowledge that as of the Third Amendment Effective Date the Agreement is expired and the Parties desire to reinstate the Agreement; and
WHEREAS, the Parties desire to extend the Term until August 31, 2022;
WHEREAS, the Parties desire to amend the plan of research;
WHEREAS, the Sponsor desires to provide US $656,788.00 additional funding to Hospitals; and
WHEREAS, Sponsor and Hospitals acknowledge that as of [*****], payments (a) through (d) described in Section 5.1 of the Agreement and totaling US [*****] have been paid in full; and
In consideration of the promises made herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Hospitals and Sponsor hereby agree as follows:
1.AMENDMENT
	1.1
	The Agreement is hereby amended by deleting Section 2 in its entirety and inserting the following language in its place:

“2. Term.  The term of this Agreement shall be from the Effective Date until August 31, 2022 (the “Term”), unless earlier terminated by either Party as set forth in Section 11 or extended in a writing signed by authorized representatives of both Parties.”
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	1.2
	The Agreement is hereby amended by deleting Section 5 in its entirety and inserting the following language in its place:

“5. Payments.  Sponsor shall pay Institute a total of one million six hundred fifty-six thousand seven hundred eighty-eight United States dollars (US $1,656,788.00) by check or wire transfer as set forth below in support of the Sponsored Research, as detailed in Budget attached hereto as Appendix B.
5.1 Payments shall be due within [*****].  Payments to the Institute shall reference the Agreement Number as set forth in the heading of this Agreement and shall be made as follows:
[*****];
[*****];
[*****];
[*****];
[*****];
[*****];
[*****];
[*****];
[*****];
[*****].
	1.3
	The Agreement is hereby amended by appending Appendix A of the Agreement with Appendix A1 attached hereto as Exhibit I.

	1.4
	The Agreement is hereby amended by appending Appendix B of the Agreement with Appendix B1 attached hereto as Exhibit II.

	1.5
	Except as herein provided, the Agreement and all of its terms, covenants and conditions are hereby ratified and confirmed in all respects and remain in full force and effect. The Agreement shall, together with this Third Amendment, be read and construed as a single agreement.

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	1.6 
	This Third Amendment may be executed in two or more counterparts, each of which will be deemed an original, but all of which together will constitute one and the same instrument. This Third Amendment may be executed electronically/digitally in compliance with the Massachusetts Uniform Electronic Transactions Act (MUETA) Mass. Gen. Laws ch. 110G and/or The Electronic Signatures In Global And National Commerce Act (ESIGN) 15 USC ch. 96. Persons signing this Third Amendment agree that, if used, electronic/digital signatures are intended to authenticate this writing and to have the same force and effect as the use of manual signatures.

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IN WITNESS WHEREOF, the parties have caused this Third Amendment to Agreement to be executed and delivered by their duly authorized representatives as of the Third Amendment Effective Date.
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	CUREVAC AG
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	THE SCHEPENS EYE RESEARCH INSTITUTE, INC.

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	By:
	/s/ Dr. Igor Splawski
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	By:
	/s/ Rebecca Listfield

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	Name:
	Dr. Igor Splawski
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	Name: 
	Rebecca Listfield, Ph.D.
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	Title:
	Chief Sceintific Officer
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	Title: 
	Managing Director, Licensing
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	Date:
	September 29, 2021
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	Date:
	September 16, 2021

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	MASSACHUSETTS EYE AND EAR INFIRMARY

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	By:
	/s/ Dr. Mariola Fotin-Mleczek
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	By: 
	/s/ Rebecca Listfibeld

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	Name:
	Dr. Mariola Fotin-Mleczek
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	Name: 
	Rebecca Listfield, Ph.D.
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	Title:
	Chief Technology Officer
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	Title: 
	Managing Director, Licensing
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	Date:
	September 30, 2021
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	Date:
	September 16, 2021

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