Document:

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                                                                    EXHIBIT 10.1

Confidential treatment has been requested for portions of this Exhibit. The copy
filed herewith omits the information subject to the confidentiality request.
Omissions are designated as [Intentionally Redacted]. A complete version of this
exhibit has been filed separately with the Securities and Exchange Commission.

                                  CONFIDENTIAL

                       LICENSE AND COLLABORATION AGREEMENT
                                       FOR
                                     D-63153

                                 by and between

                                  Zentaris GmbH
                              Weismullerstrasse 45
                             60314 Frankfurt am Main
                                     Germany

                              - herein "Zentaris" -

                                       and

                         Spectrum Pharmaceuticals, Inc.
                              157 Technology Drive
                                Irvine, CA 92602
                                     U.S.A.

                             - herein "Spectrum" -

                                   WITNESSETH:

      Whereas, Zentaris is the owner of certain patents and know-how relating to
a compound known as "D-63153"; and

      WHEREAS, Spectrum desires to obtain certain licenses from Zentaris to
develop and commercialize D-63153 under the aforesaid patents and know-how, and
Zentaris is willing to grant to Spectrum such licenses; and

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      NOW, THEREFORE, in consideration of the foregoing, the Parties to this
Agreement do agree as follows.

1.    DEFINITIONS

      For purposes of this Agreement, the following terms shall have the
      following meanings:

1.1   "AFFILIATE" shall mean and include in relation to each Party, any person,
      firm, corporation or other entity: (i) if at least fifty percent (50%) of
      the voting stock or other equity interest thereof is owned, directly or
      indirectly, by that Party; (ii) which owns, directly or indirectly, at
      least fifty percent (50%) of the voting stock or other equity interest of
      that Party; or (iii) if at least fifty percent (50%) of the voting stock
      or other equity interest thereof is owned, directly or indirectly, by a
      person, firm, corporation or other entity that owns, directly or
      indirectly, at least fifty percent (50%) of the voting stock or other
      equity interest of that Party.

1.2   "AGREEMENT" shall mean this agreement and all Exhibits attached hereto,
      and the terms "herein", "hereunder", "hereto" and such similar expressions
      shall refer to this Agreement.

1.3   "CONFIDENTIAL INFORMATION" shall mean and include all of know-how, data
      and information, not in the public domain, relating to D-63153, the
      Contract Products, the Indications, or the business, affairs, research and
      development activities, results of clinical trials, national and
      multinational regulatory proceedings and affairs, finances, plans,
      contractual relationships and operations of the Parties.

1.4   "CONTRACT PRODUCTS" shall mean and include all pharmaceutical products,
      manufactured by Spectrum hereunder, whether as mono-preparations or
      combination-preparations, with the D-63153 as an active ingredient, for
      use in the Field, in any form of administration whatsoever.

1.5   "COPYRIGHT" means any copyright, mask work or other right of authorship,
      whether registered or unregistered and including any registrations and
      applications therefore.

1.6   "D-63153" shall mean the compound described in Exhibit 1.6 hereto, which
      may be covered by one or more of Zentaris' Patent Rights as listed in
      Exhibit 1.29 for use in the Field.

1.7   "DEVELOPMENT DATA" shall mean reports of clinical studies and all other
      documentation containing or embodying any pre-clinical, clinical and
      chemistry, manufacturing and controls data relating to the application for
      Regulatory Approval for the Contract Products and/or Compound or the use
      of Contract Products and/or D-63153 in the Field, including, but not
      limited to, registration dossiers.

1.8   "DEVELOPMENT PLANS" shall mean the plans to develop two Indications from
      the Initial Indications, such plans describing the development and
      commercialization milestones and setting forth estimated timelines to
      achieve such milestones, which such milestones and estimated timelines
      will be periodically reviewed and updated by the Steering Committee.

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1.9   "DOMAIN NAME" means any Internet domain name, including top-level Internet
      domain names and all lower-level Internet domain names for which such
      top-level domains are a root or parent, whether in the form of an address
      for use in electronic mail transfer, a Universal Resource Locator, a File
      Transfer Protocol location, or other form suitable for specifying the
      location of an electronic data file over a distributed computer network.

1.10  "EFFECTIVE DATE" of this Agreement shall mean the date on which this
      Agreement is executed by the duly authorized representatives of each of
      the Parties hereto.

1.11  "EXPLORATORY DEVELOPMENT PLANS" shall mean the plans for exploratory work
      limited to Phase I and Phase IIa studies in all three Initial Indications,
      such plans to describe the estimated timelines for completing such
      studies, which such estimated timelines will be periodically reviewed and
      updated by the Steering Committee.

1.12  "FIELD" shall mean the use of D-63153 and/or Contract Products for all
      human uses.

1.13  "FIRST COMMERCIAL SALE" shall mean in relation to each country within the
      Territory, first sale by Spectrum or its Affiliates, licensees, or
      distributors of any of the Contract Products for use in the Field in that
      country, after obtaining all of the applicable Regulatory Approvals.

1.14  "IMPROVEMENTS" to the Contract Products and/or D-63153 shall mean and
      include any and all Inventions, and any and all changes, modifications and
      amendments to Zentaris' Know-How which: (i) improve the performance or
      efficacy of the Contract Products and/or D-63153; (ii) reduce any side
      effects, drug interactions or other adverse effects of the Contract
      Products and/or D-63153; or (iii) reduce the cost and/or increase the
      efficiency or productivity of the manufacturing and production processes
      for the Contract Products.

1.15  "INDICATION(s)" shall mean the Initial Indications and all other
      indications within the Field.

1.16  "INITIAL INDICATION(s)" shall mean the use of D-63153 and/or Contract
      Products for (i) prostate cancer; (ii) benign prostate hyperplasia (BPH);
      and (iii) endometriosis.

1.17  "INTELLECTUAL PROPERTY" means, collectively, Trademarks, Patents,
      Copyrights, Domain Names, Trade Secrets and any other proprietary,
      intellectual property and other rights relating to any or all of the
      foregoing anywhere in the world.

1.18  "INVENTIONS" shall mean any new or useful method, process, manufacture,
      compound or composition of matter, whether or not patentable or
      copyrightable, or any improvement thereof.

1.19  "LHRH PATENTS" shall mean the composition in matter patents regarding
      [Intentionally Redacted].

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1.20  "NET SALES" shall mean the amount received by Spectrum, its Affiliates,
      its sublicensees or distributors on account of sales of a Contract Product
      to Third Parties in the Territory, less the following deductions to the
      extent actually allowed or specifically allocated to the Contract Product
      by the selling party using generally accepted accounting standards:

      (i)   sales and excise taxes and duties paid or allowed by the selling
            party and any other governmental charges imposed upon the
            production, importation, use or sale of such Contract Product;

      (ii)  customary trade, quantity and cash discounts allowed on Contract
            Product;

      (iii) allowances or credits to customers on account of rejection or return
            of Contract Product or on account of retroactive price reductions
            affecting such Contract Product;

      (iv)  freight and insurance costs, if they are included in the selling
            price for the Contract Product invoiced to Third Parties, provided
            always that such deduction shall not be greater than the balance
            between the selling price actually invoiced to the Third Party and
            the standard selling price which would have been charged to such
            Third Party for such Contract Product exclusive of freight and
            insurance in the respective country or in a comparable country.

      For the avoidance of doubt, for each Contract Product the Net Sales shall
      be calculated only once for the first sale of such Contract Product by
      either Spectrum, its Affiliate, its sublicensees or its distributor, as
      the case may be, to a Third Party which is neither an Affiliate,
      sublicensee or distributor of Spectrum. A sale of Contract Products by
      Spectrum, its Affiliate, its sublicensee or its distributor to a
      wholesaler shall be regarded as the first sale of the Contract Product for
      the purpose of calculating Net Sales.

1.21  "PARTY" or "PARTIES" shall mean Spectrum or Zentaris, or Spectrum and
      Zentaris, as the context admits.

1.22  "PATENT" means any patent or patent application, Invention disclosure, and
      other rights of Invention worldwide including, but not limited to, any
      continuations, continuations-in-part, divisionals, reissues, renewals,
      provisional patents, reexamined patents, applications for any of the
      foregoing or other applications or patents claiming the benefit of the
      filing date of any such application or patent.

1.23  "REGULATORY APPROVALS" shall mean and include all licenses, permits,
      authorizations and approvals of, and all registrations, filings and other
      notifications to, any governmental agency or department within the
      Territory, including, without limitation, the United States Food and Drug
      Administration (FDA) necessary or appropriate for the manufacture,
      production, distribution, marketing, sale and/or use of the Contract
      Products and/or D-63153 within the Field and in the Territory.

1.24  "TERRITORY" shall mean and include the United States, Canada, Mexico and
      India.

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1.25  "THIRD PARTY" shall mean any other party that is independent from Spectrum
      and its Affiliates and Zentaris and its Affiliates.

1.26  "TRADE SECRET" means any confidential information and proprietary
      information, including any formula, pattern, compilation, program, device,
      method, technique, or process, that: (1) derives independent economic
      value, actual or potential, from not being generally known to the public
      or to other persons who can obtain economic value from its disclosure or
      use; and (2) is the subject of efforts to maintain its secrecy.

1.27  "TRADEMARK" means trademark, service mark trade dress, trade name, design,
      logo, product name and slogan, (whether registered or unregistered, and
      including any common law rights, registrations, and applications for
      registration for any of the foregoing) and general intangible of like
      nature, together with all goodwill related to the foregoing.

1.28  "ZENTARIS' KNOW-HOW" shall mean and include all specifications, results of
      clinical trials, technical data and other information relating to the
      design, formulation, manufacture, production, quality control, Regulatory
      Approvals, distribution, sale and/or use of D-63153 in the Field, to which
      Zentaris has rights as at the Effective Date. Without limiting the
      generality of the definition set forth in this Section 1.28, the Zentaris
      Know-How is described in more detail in Exhibit 1.28 hereto.

1.29  "ZENTARIS' PATENT RIGHTS" shall mean patents, patent applications,
      divisions, continuations, continuation-in-part applications, divisionals,
      extensions, substitutions, renewals, confirmations, supplementary
      protection certificates and reissues that are owned by Zentaris relating
      to, embodied in, or associated with the Contract Products and/or D-63153.
      Without limiting the generality of the definition set forth in this
      Section 1.29, the Zentaris' Patent Rights are listed in more detail in
      Exhibit 1.29 hereto.

2.    GRANT AND SCOPE OF LICENSE

2.1   Zentaris hereby grants to Spectrum, and Spectrum hereby accepts

      (i)   an exclusive license as of the Effective Date to use Zentaris'
            Patent Rights and Zentaris' Know-How to develop, use, sell, offer
            for sale, have sold, import and export, commercialize, and

      (ii)  a non-exclusive license to use the Zentaris' Patent Rights and
            Zentaris' Know-How to make and have made (except in cases where
            Zentaris is supplying the finished dosage form of D-63153 and/or
            Contract Products to Spectrum)

      Contract Products and/or D-63153 in the Field and in the Territory, in
      accordance with the terms and conditions, and subject to the limitations
      of this Agreement. The license shall include the right to use Zentaris'
      Patent Rights and Zentaris' Know-How in conducting research and
      development activities with respect to the use of Contract Products and/or
      D-63153 in the Field. [Intentionally Redacted].

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2.2   Spectrum shall be entitled to sublicense all or any of its rights under
      this Agreement to any Affiliate and, in respect of the commercialization
      of Contract Products and D-63153, to any Third Party. Spectrum may
      sublicense its rights under this Agreement in respect of the development
      of Contract Products and D-63153, including activities related to the
      obtainment of Regulatory Approvals for Contract Products and D-63153, to
      any Third Party only upon prior written consent of Zentaris, which consent
      shall not be unreasonably withheld. Any sublicense granted is subject to
      the participation payments specified in Section 4.3 below. In case
      Spectrum grants sublicenses hereunder, Spectrum always shall secure
      appropriate covenants, obligations and rights from any such sublicensee so
      as to ensure that such sublicensee is also able to comply with Spectrum's
      covenants and obligations hereunder to the extent that Spectrum shall not
      be performing such covenants and obligations. Spectrum shall inform
      Zentaris of any sublicenses granted hereunder, and provide to Zentaris a
      copy of the sublicense agreement concluded with such sublicensee. Zentaris
      acknowledges that all and any information provided by Spectrum to Zentaris
      under this Section 2.2 will be deemed to be Confidential Information of
      Spectrum and will be subject to the terms of Section 12. However, Spectrum
      may redact confidential portions of any such sublicense agreement, but
      only to the extent that any such redactions do not impair Zentaris'
      ability to ensure compliance with the provisions of this Agreement,
      including but not limited to the calculation of the participation payments
      specified in Section 4.3.

2.3   Subject to Section 2.4 below, Zentaris will not at any time during the
      continuance of this Agreement grant to any person, firm, corporation or
      entity a license to develop, use, sell, offer for sale or import Contract
      Products and/or D - 63153 in the Field and in the Territory.

2.4   The grant of licenses by Zentaris to Spectrum under Section 2.1 hereof
      shall not preclude Zentaris and/or its Affiliates from utilizing Zentaris'
      Patent Rights and Zentaris' Know-How and any Improvements relating thereto
      for the purpose of carrying out by itself or through a University, a
      contract research organization or a non-profit organization (provided that
      a material transfer agreement is in place to protect any intellectual
      property rights generated) any further non-commercial exploratory and
      development work relating to D-63153. Other than the limited use described
      in this Section 2.4, the license granted to Spectrum under Sections 2.1
      and 2.2 shall be exclusive even as to Zentaris.

2.5   In furtherance of the rights and licenses granted by Zentaris to Spectrum
      under this Agreement, within thirty (30) days after the Effective Date of
      this Agreement, Zentaris shall furnish to Spectrum a data package that
      shall include (i) all of the Zentaris' Know-How as well as (ii) any and
      all information, including, without limitations data and reports for IND
      submission to the FDA, [Intentionally Redacted] has on the Contract
      Products and D-63153 to the extent such information is available to
      Zentaris and under Zentaris' control [Intentionally Redacted]. Spectrum
      shall not use any of the Zentaris' Know-How and [Intentionally Redacted]
      furnished by Zentaris under this Section 2.5 for any purpose whatsoever,
      except as specifically authorized in this Agreement, or as otherwise
      specifically authorized in writing by

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      Zentaris. In the event that Spectrum reasonably believes that the
      Zentaris' Know-How or [Intentionally Redacted] included in the data
      package furnished by Zentaris under this Section 2.5 is incomplete,
      Spectrum shall provide written notice thereof to Zentaris, and Zentaris
      shall furnish corrected copies of such Zentaris' Know-How and
      [Intentionally Redacted] within sixty (60) days after receipt of
      Spectrum's written notice hereunder. Zentaris shall use its reasonable
      endeavors to answer all questions received from Spectrum regarding the
      Zentaris' Know-How and [Intentionally Redacted] as soon as reasonably
      possible after receipt.

2.6   Zentaris shall execute all documents, give all declarations regarding the
      licenses granted hereunder and reasonably cooperate with Spectrum at the
      costs of Spectrum to the extent such documents, declarations and/or
      cooperation are required for the recordal or registration of the licenses
      granted hereunder at the various patent offices in the Territory for the
      benefit of Spectrum.

2.7   Without limiting the generality of Section 2 hereof, Spectrum specifically
      acknowledges and agrees that the license granted to Spectrum hereunder is
      limited to development, use, and commercialization of the Contract
      Products and D-63153 in the Field within the Territory, and subject to any
      mandatory legal provisions which may apply, Spectrum shall not knowingly
      develop, distribute, market, sell or use any of the Contract Products or
      D-63153 for any other application or purpose whatsoever, and shall not
      actively promote, or solicit orders for the sale of the Contract Products
      outside of the Territory, without the prior written authorization of
      Zentaris, which Zentaris may grant or withhold in its sole discretion

3.    SPECTRUM'S OBLIGATIONS

3.1   Spectrum shall use its commercially reasonable efforts to develop, market
      and sell the Contract Products in the Territory in order to maximize the
      Net Sales derived from the Contract Products throughout the continuance of
      this Agreement. Without limiting the generality of Spectrum's commercially
      reasonable efforts obligation under this Section 3.1, Spectrum shall:

      (i)   apply for all required Regulatory Approvals in the countries within
            the Territory following completion of all appropriate clinical
            trials;

      (ii)  make the First Commercial Sale of the Contract Products in each
            country following the issuance of the Regulatory Approvals required
            for the manufacturing, distribution, marketing, sale and use of the
            Contract Products in the respective country and if appropriate, the
            completion of reimbursement negotiations; and

      (iii) not manufacture, produce, distribute, market or sell any products
            which are directly competitive with the Contract Products in any
            country within the Territory, to the extent that any such activities
            would involve the use of any of Zentaris' Patent Rights, Zentaris'
            Know-How or any other Zentaris Confidential Information.

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3.2   Notwithstanding Section 15.2 below, in the event that Spectrum materially
      breaches any of its obligations under Section 3.1 hereof, and if after
      having received written notice of such breach from Zentaris, Spectrum
      fails to cure such breach within ninety (90) days after receipt of
      Zentaris' notice thereof, Zentaris shall have the right to convert the
      exclusive license rights granted to Spectrum in the relevant country and
      for the relevant Initial Indication into non-exclusive license rights, by
      furnishing written notice thereof to Spectrum and shall be entitled to use
      all Development Data generated by Spectrum hereunder for the development
      and commercialization of Contract Products and/or D-63153 in the relevant
      country.

3.3   After the First Commercial Sale in the Territory, Spectrum shall furnish
      Zentaris with quarterly reports of all of Spectrum's sales of Contract
      Products under this Agreement. Each such quarterly report shall (i) be
      furnished to Zentaris together with payment of royalties in accordance
      with Section 4.9 within ninety (90) days after the close of the calendar
      quarter to which it corresponds; and (ii) state Spectrum's total sales of
      the Contract Products, broken down by country, during the calendar
      quarter, the Net Sales derived by Spectrum from such sales, and the
      royalties payable by Spectrum to Zentaris with respect to such Net Sales
      pursuant to Section 4.5 of this Agreement. In addition, commencing on
      first April 1 following the date of the First Commercial Sale in the
      Territory, Spectrum shall provide Zentaris on or before April 1 in each
      calendar year with a summary of its marketing activities performed in the
      major international markets in the previous calendar year and its
      marketing plans for that calendar year.

4.    PAYMENTS AND ROYALTIES

4.1   In consideration for the rights and licenses granted by Zentaris to
      Spectrum under this Agreement, Spectrum shall pay to Zentaris the lump sum
      amount of EURO One Million ((euro)1,000,000) in cash payable on the
      Effective Date and [Intentionally Redacted] in common stock of Spectrum
      (the "Initial Shares") as soon as reasonably practicable after the
      Effective Date, but no later than 5 business days thereafter. The number
      of shares of common stock of Spectrum that shall constitute the Initial
      Shares shall be determined by (i) converting [Intentionally Redacted] to
      U.S. dollars at the exchange rate [Intentionally Redacted] as published in
      the Wall Street Journal [Intentionally Redacted], and then (ii) dividing
      the resulting dollar amount by [Intentionally Redacted] of Spectrum's
      common stock, as traded on the NASDAQ, [Intentionally Redacted], as set
      forth in the Wall Street Journal [Intentionally Redacted]. The Initial
      Shares shall be issued to Zentaris on the Effective Date, but shall be
      held by Zentaris and may not be assigned, transferred, sold or otherwise
      disposed of by Zentaris (with the exception only of an assignment or
      transfer to an Affiliate of Zentaris, provided that such Affiliate agrees
      to be bound by the restrictions on transfer of such Initial Shares set
      forth or referred to in Sections 4.1 and 13 of this Agreement) until
      December 31, 2005. The Initial Shares shall be subject to the restrictions
      on resale set forth or referred to in Sections 4.1 and 13 of this
      Agreement. To Spectrum's present knowledge, except for the restrictions on
      resale set forth or referred to in Sections 4.1 and 13 of this Agreement,
      the Shares shall be free of restrictions on transfer after December 31,
      2005.

4.2   In addition to the lump sum payment specified in Section 4.1 hereof and as
      further consideration for the rights and licenses granted by Zentaris to
      Spectrum under this Agreement, Spectrum shall make the following milestone
      payments to Zentaris, up to a maximum of [Intentionally Redacted]:

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(i)   upon completion of the first Phase II study conducted by or on behalf of
      Spectrum, its Affiliates or Sublicensees [Intentionally Redacted]
                                                       [Intentionally Redacted];

(ii)  upon initiation of the first Phase III study conducted by or on behalf
      of Spectrum, its Affiliates or sublicensees and after the first patient in
      the Phase III trial has been dosed
                                                       [Intentionally Redacted];

(iii) after [Intentionally Redacted] of the patients in the Phase III trial have
      been dosed
                                                       [Intentionally Redacted];

(iv)  upon acceptance by the FDA of submission for Regulatory Approval

                                                       [Intentionally Redacted];

(v)   upon the first grant of Regulatory Approval for marketing for a Contract
      Product in the Territory
                                                       [Intentionally Redacted];

(vi)  upon the first grant of Regulatory Approval for marketing for a product
      with D-63153 as an active ingredient in Japan
                                                       [Intentionally Redacted].

      [Intentionally Redacted].

      [Intentionally Redacted].

      Spectrum shall inform Zentaris on the occurrence of a milestone event as
      soon as possible, however, not later than within fourteen (14) days
      following the occurrence of such milestone event. Milestone payments are
      payable within thirty (30) days after Spectrum's receipt of an invoice
      issued by Zentaris for such milestone payment.

4.3   In case Spectrum grants sublicenses under Section 2.2 hereof, Spectrum
      shall pay to Zentaris [Intentionally Redacted] percent ([Intentionally
      Redacted]%) of any lump sum, periodic or other consideration (other than
      royalties based on Net Sales) received by Spectrum from sublicensees
      including, but not limited to, equity, any upfront fees, sublicense fees,
      marketing rights, or other consideration paid for the authorization to use
      the Zentaris' Patent Rights and/or Zentaris' Know-How to develop, use,
      sell, offer for sale, have sold, import and export, commercialize, make
      and have made Contract Products. For the avoidance of doubt, the foregoing
      obligation shall not apply in respect of any sums received from
      sublicensees on which Spectrum has or is obliged to pay royalties pursuant
      to Section 4.5 hereof.

4.4   All fees payable by Spectrum to Zentaris under Sections 4.1, 4.2 and 4.3
      hereof are non-refundable upon expiration or termination of this Agreement
      for any reason whatsoever assuming such fees have become due during the
      term of this Agreement. None of the fees payable by Spectrum to Zentaris
      under Sections 4.1, 4.2 and 4.3 may be credited against any of Spectrum's
      royalty obligations under Section 4.5 hereof.

4.5   As further consideration for the rights and licenses granted by Zentaris
      to Spectrum under this Agreement, Spectrum shall pay royalties to Zentaris
      equal to [Intentionally Redacted] percent ([Intentionally Redacted]%) of
      Net Sales for annual Net Sales up to [Intentionally Redacted] US dollars
      ($[Intentionally Redacted]), [Intentionally Redacted]% of Net Sales for
      annual Net Sales between [Intentionally Redacted] US dollars
      ($[Intentionally Redacted]) and [Intentionally Redacted] US dollars

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      ($[Intentionally Redacted]) and [Intentionally Redacted]% of Net Sales for
      annual Net Sales exceeding [Intentionally Redacted] US dollars
      ($[Intentionally Redacted]).

4.6   As consideration for the payment by Spectrum to Zentaris under Section 4.2
      (vi), Zentaris shall pay to Spectrum for sales of products with D-63153 as
      an active ingredient in Japan either (i) fifty percent (50%) of profits on
      sales of products with D-63153 as an active ingredient in Japan, or (ii)
      fifty percent (50%) of any lump sum, periodic or other consideration
      received by Zentaris from sublicensees including, but not limited to,
      royalties, equity, sublicense fees, marketing rights, or other
      consideration paid for the authorization to use the Zentaris' Patent
      Rights and/or Zentaris' Know-How to develop, use, sell, offer for sale,
      have sold, import and export, commercialize, make and have made products
      with D-63153 as an active ingredient in Japan. Sections 4.8 et seq. hereof
      shall apply mutatis mutandis regarding the payments of Zentaris to
      Spectrum under this Section 4.6.

4.7   In the event that a Contract Product is sold in the form of a
      combination-preparation for which Spectrum is required to pay a royalty
      for an active ingredient to a Third Party (that is not an Affiliate of
      Zentaris), the Net Sales attributable to such combination preparation
      shall be calculated on a country by country basis by multiplying actual
      Net Sales of the combination preparation by the fraction A/(A+B)*C, where
      "A" is Spectrum's (or its Affiliates, sublicensees or distributors)
      average selling price for D 63153 and "B" is Spectrum's (or its
      Affiliates, sublicensees or distributors) average selling price for the
      Third Party ingredient(s) when sold in a mono-preparation in the relevant
      country during the period to which the Net Sales calculation applies or
      the fair market price if sold to an Affiliate and "C" is Spectrum's (or
      its Affiliates', sublicensees' or distributors', as applicable) actual Net
      Sales of the combination preparation during such period or the fair market
      price if sold to an Affiliate.

4.8   Royalty payments shall be made on a country-by-country and a Contract
      Product-by-Contract Product basis, however, in countries of the Territory
      where the Contract Products are no longer covered by a valid claim of a
      Zentaris Patent Right and Spectrum does not have exclusive
      commercialization rights in respect of Contract Product as a result of
      generic competition by a Third Party (other than an Affiliate or
      sublicensee of Spectrum), Spectrum shall not pay any royalties on Net
      Sales for such Contract Product in such country, provided that in case of
      such generic competition in India the Parties agree to discuss a payment
      of royalties for such Contract Product.

4.9   All payments by Spectrum to Zentaris under this Agreement shall be paid in
      EURO to the following account:

                            [Intentionally Redacted]

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      For purposes of calculating the amounts payable by Spectrum under Sections
      4.3 and 4.5 hereof, such payments shall be converted into Euros at the
      prevailing open market currency conversion rate (commercial selling rate)
      as quoted by the Wall Street Journal fixing rate, issued by Reuters at 3
      pm on the last day of the calendar quarter in which such payments were
      received by Spectrum.

4.10  Participation payments and royalties under Sections 4.3 and 4.5 shall be
      paid on a calendar quarterly basis. Each quarterly payment by Spectrum
      under Sections 4.3 and 4.5 shall be paid within ninety (90) days after the
      close of the calendar quarter to which it corresponds.

4.11  In the event that any fee payable by Spectrum under Sections 4.1 and 4.2
      is not paid to Zentaris on or before the due date therefore, as specified
      herein, or any quarterly participation or royalty payment under Sections
      4.3 and 4.5 is overdue, the unpaid overdue amount shall bear interest at a
      rate equal to three (3) percentage points over LIBOR.

4.12  All payments by Spectrum to Zentaris under this Section 4 shall be paid in
      full, without deduction for any sales, use, excise or other similar taxes
      which shall be Zentaris' obligation. All payments are exclusive of value
      added tax, which shall, if applicable, be invoiced separately. In the
      event that Spectrum is required to withhold any taxes on any amount
      payable to Zentaris hereunder, under the applicable laws of any country
      within the Territory, Spectrum shall at Zentaris' request and cost use its
      best efforts to obtain and furnish Zentaris with official tax receipts, or
      other evidence of payment of such withholding taxes, sufficient to permit
      Zentaris to demonstrate the payment of such withholding taxes, in order to
      establish Zentaris' right to a credit for such withholding taxes against
      Zentaris' German income tax liability. Spectrum shall provide Zentaris
      with all assistance reasonably requested by Zentaris in connection with
      any application to any competent tax authorities in any country within the
      Territory to qualify for the benefit of a reduced rate of withholding
      taxation under any applicable Double Tax Treaty.

4.13  For the term of this Agreement and for a term of three (3) years
      thereafter, Spectrum shall maintain complete and accurate books and
      records of account, in accordance with generally accepted accounting
      principles, of all transactions and other business activities under this
      Agreement, sufficient to confirm the accuracy of all reports furnished by
      Spectrum to Zentaris under Section 3.3 hereof, and all payments by
      Spectrum to Zentaris under this Section 4. Upon reasonable written notice
      to Spectrum, Zentaris may request Spectrum's certified public accountant
      to audit such books and records of account of Spectrum and to review the
      terms of any sublicenses granted by Spectrum, in order to confirm the
      accuracy and completeness of all such reports and all such payments.
      Zentaris shall bear all costs and expenses incurred in connection with any
      such audit. If Zentaris disagrees with the report provided by Spectrum's
      accountant, with reasonable justification for such disagreement, then upon
      reasonable written notice to Spectrum, a certified public accountant
      designated by Zentaris and acceptable to Spectrum shall have the right to
      audit such books and records of account of Spectrum and to review the
      terms of any sublicenses granted by Spectrum, in order to confirm the
      accuracy and completeness of all such reports and all such payments.
      Zentaris shall bear all costs and expenses incurred in connection with any
      such audit; provided, however, that if any such audit reveals an

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      underpayment of [Intentionally Redacted] percent ([Intentionally
      Redacted]%) or more between the amount of payments actually due and the
      amount of payments made to Zentaris for the audit period, then, in
      addition to paying the full amount of such underpayment, plus accrued
      interest, Spectrum shall reimburse Zentaris all such audit costs and
      expenses incurred. If the audit reveals an overpayment, Zentaris shall pay
      the full amount of the such overpayment to Spectrum.

5.    DEVELOPMENT WORK, STEERING COMMITTEE

5.1   Spectrum shall be solely responsible for conducting all necessary research
      and development activities (pre-clinical, chemistry, manufacturing and
      controls and clinical development) necessary for the Territory and for
      bearing all costs and expenses related to such development activities in
      accordance with the Exploratory Development Plans and the Development
      Plans in order to maximize the commercial potential, if any, of the
      Contract Products in the Territory.

5.2   The Steering Committee (defined in Section 5.3 below) shall prepare,
      within [Intentionally Redacted] of its formation, three Exploratory
      Development Plans for exploratory work limited to Phase I and Phase IIa
      studies in all three Initial Indications. At completion of this
      exploratory work, the Steering Committee will evaluate the results,
      prioritize the Initial Indications and prepare Development Plans, if
      scientifically, medically and commercially warranted, for two of the
      Initial Indications. The Steering Committee shall have the ability to
      review and update any milestones or estimated timelines included in the
      Exploratory Development Plans and the Development Plans. Spectrum may
      pursue additional indications.

5.3   Immediately after the Effective Date, the Parties shall form a Steering
      Committee, which shall be comprised of up to six (6) professionally and
      technically qualified representatives, three (3) from each Party. The
      Steering Committee shall meet for the first time within four (4) weeks
      after the Effective Date, and thereafter as often as necessary, but at
      least every calendar half year. The meeting place shall be mutually agreed
      to by the Parties. Each Party shall provide the other Party with written
      notice of its representatives for the Steering Committee within ten (10)
      days after the Effective Date of this Agreement and, thereafter,
      immediately upon replacement. The Parties shall be jointly responsible for
      directing the activities of the Steering Committee, which activities shall
      include but not be limited to the review, validation, modification and/or
      update of the Exploratory Development Plans and the Development Plans.

5.4   All decisions of the Steering Committee shall be made in good faith in the
      best interest of this Agreement and the Parties shall use their reasonable
      efforts to take decisions unanimously. In the event that the Steering
      Committee is unable to agree on any matter after good faith attempts to
      resolve such disagreement in a commercially reasonable fashion, then the
      Chief Executive Officer of Spectrum and the Chairman and Managing Director
      of Zentaris shall meet to discuss the matter and

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      use their best efforts to resolve the matter. If they are unable to do so,
      the Chief Executive Officer of Spectrum shall decide the matter.

5.5   Each Party shall keep the other Party informed of relevant or material
      development activities performed by it in connection with the development
      and commercialization of Contract Products and/or D-63153 and shall
      provide the other Party with written notice of all clinical studies,
      including any known investigator initiated trials, together with the
      results thereof, when available.

6.    USE OF DEVELOPMENT DATA

6.1   Subject to Section 6.2 below, each Party will disclose to the other Party
      all Development Data, which it generates or which is generated by in
      Zentaris' case, its licensees and in Spectrum's case, its sublicensees
      during the continuance of this Agreement. Each Party shall be entitled to
      disclose such Development Data to in Zentaris' case, its licensees and in
      Spectrum's case, its sublicensees. Spectrum shall ensure that its
      sublicensees agree to (i) permit Spectrum to disclose their Development
      Data to Zentaris and its licensees and (ii) keep confidential all
      Development Data disclosed to them pursuant to this Section 6.1. Zentaris
      shall ensure that its licensees agree to (i) permit Zentaris to disclose
      their Development Data to Spectrum and its sublicensees and (ii) keep
      confidential all Development Data disclosed to them pursuant to this
      Section 6.1. All Development Data disclosed pursuant to this section shall
      be deemed Confidential Information.

6.2   Each Party, licensees and sublicensees (as the case may be) shall be
      entitled to use the Development Data disclosed to it pursuant to Section
      6.1 for the development and commercialization of D-63153 and/or Contract
      Product in accordance with the terms of this Agreement free of charge.

7.    IMPROVEMENTS

7.1   Spectrum hereby acknowledges that Zentaris is the owner of all Inventions
      and/or Improvements developed by Zentaris and Spectrum shall acquire no
      rights, title or interest whatsoever in or to any such Inventions and/or
      Improvements, except as specifically provided herein.

7.2   In the event that, during the continuance of this Agreement, Zentaris
      develops any Improvements with respect to the use of Contract Products
      and/or D-63153 in the Field, Zentaris shall furnish Spectrum with timely
      written notice of such Improvements, and shall furnish Spectrum with a
      data package which, in Zentaris' reasonable opinion, contains all
      information, know-how and other data as Spectrum will require in order to
      implement such Improvements. Zentaris shall, and hereby does, grant
      Spectrum an exclusive, perpetual, royalty-free license to use all
      Improvements and all information, know-how and other data pertaining to
      all Improvements furnished by Zentaris to Spectrum hereunder for the
      purpose of developing, selling, offering for sale and importing Contract
      Products and/or D-63153 in the Field and in the Territory, and subject to
      the limitations as provided for in Section 2 above.

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7.3   Zentaris hereby acknowledges that Spectrum is the owner of all Inventions
      and/or Improvements developed by Spectrum and Zentaris shall acquire no
      rights, title or interest whatsoever in or to any such Inventions and/or
      Improvements, except as specifically provided herein.

7.4   In the event that, during the continuance of this Agreement, Spectrum
      develops any Improvements with respect to the use of Contract Products
      and/or D-63153 in the Field, Spectrum shall furnish Zentaris with timely
      written notice of such Improvements, and shall furnish Zentaris with a
      data package which, in Spectrum's reasonable opinion, contains all
      information, know-how and other data as Zentaris will require in order to
      implement such Improvements in Zentaris' Regulatory Approvals and for
      manufacture, production, distribution, marketing, sale and/or use of any
      products whatsoever. Spectrum shall, and hereby does, grant Zentaris an
      exclusive, worldwide, perpetual, royalty-free license to use all
      Improvements and all information, know-how and other data pertaining to
      all Improvements furnished by Spectrum to Zentaris hereunder, outside the
      Territory and within the Territory outside the Field for any purpose
      whatsoever.

7.5   Each Party shall be entitled to disclose all Improvements disclosed to it
      by the other Party during the period of this Agreement to, in Zentaris'
      case, its licensees and, in Spectrum's case, its sublicensees. During the
      term of this Agreement, the use of Zentaris' Improvements by any
      sublicensees of Spectrum and the use of Spectrum's Improvements by any
      licensee of Zentaris is free of charge. All information regarding such
      Improvements and Inventions shall be deemed Confidential Information and
      each Party, and each of its licensees, shall keep such information
      confidential pursuant to the terms of Section 12.

8.    SUPPLY OF D-63153

8.1   Unless Zentaris informs Spectrum that it is no longer willing or able to
      supply D-63153 bulk substance, and assuming the API and finished dosage
      form manufacturers' continued compliance with cGMP, Spectrum shall
      purchase all D-63153 bulk substance and/or finished dosage forms
      (collectively referred to "Clinical Supplies") required for development of
      Contract Products and/or D-63153 exclusively from Zentaris. Exhibit 8.1
      hereto sets forth the specification for the Clinical Supplies (to be
      determined within a reasonable time after execution of the Agreement) to
      be delivered to Spectrum, and any change of such specifications shall be
      agreed between the Parties acting reasonably at least six (6) months prior
      to such change becoming effective.

8.2   Spectrum shall at the beginning of each calendar quarter present to
      Zentaris a written rolling forecast specifying its estimated demand for
      Clinical Supplies for the following twelve (12) months. Any purchase order
      by Spectrum shall be firm and binding and not deviate from the quantity
      indicated in the rolling forecast by more than [Intentionally Redacted].
      Unless otherwise agreed, each quantity of Clinical Supplies ordered by
      Spectrum shall be delivered to such address as may be specified by
      Spectrum no later than six (6) months following Zentaris' receipt of the
      relevant

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      purchase order. The price for Clinical Supplies will be the actual price
      paid by Zentaris for manufacturing and laboratory services including the
      price for API, plus a handling and managing surcharge of [Intentionally
      Redacted] percent ([Intentionally Redacted]%). However, the price for API
      is agreed to be EURO [Intentionally Redacted] ((euro)[Intentionally
      Redacted]) per [Intentionally Redacted]. Payment of the purchase price
      shall be made within thirty (30) days after the receipt of Zentaris'
      invoice.

8.3   If Spectrum discovers any non-conformance of Clinical Supplies with the
      agreed terms and specifications as set forth in Exhibit 8.1 hereto, it
      shall promptly notify Zentaris of such non-conformance. Spectrum shall
      examine each shipment within four (4) weeks from delivery regarding the
      conformance with the agreed terms and specifications. In the event
      Spectrum does not notify Zentaris of acceptance or rejection within such
      four (4) weeks period, the whole shipment is deemed to be accepted, except
      for hidden defects, which Spectrum could not reasonably detect. In case of
      a non-conformance, Zentaris shall replace at its expense such
      non-conforming shipment as soon as possible. Upon Zentaris' request and
      expense, Spectrum shall return a non-conforming shipment to the address
      stated by Zentaris.

8.4   If, for whatever reason, including a change in the manufacturing process
      or the specifications requested by the competent regulatory authorities,
      Zentaris is no longer willing or able to ensure Clinical Supply, Zentaris
      shall immediately inform Spectrum hereof and Spectrum shall automatically
      obtain for the duration of this Agreement a non-exclusive license to use
      the Zentaris' Patent Rights and the Zentaris' Know-How to manufacture
      and/or have manufactured Clinical Supply for purposes of this Agreement.

8.5   Vials in the possession of Zentaris and available for clinical studies at
      the Effective Date will be provided to Spectrum free of charge.

8.6   The supply of a finished dosage form of D-63153 and/or Contract Products
      for commercialization will be subject of a separate agreement between the
      Parties. The Parties will discuss entering into a joint supply agreement.
      If Zentaris is unable or unwilling to supply D-63153 and/or Contract
      Products to Spectrum at reasonable terms, including but not limited to
      competitive prices, Spectrum shall automatically obtain for the duration
      of this Agreement a non-exclusive license to use the Zentaris' Patent
      Rights and the Zentaris' Know-How to manufacture and/or have manufactured
      the commercial supply for purposes of this Agreement.

8.7   Zentaris shall, at its sole cost and expense, obtain no later than on the
      date of first delivery of Clinical Supplies to Spectrum and maintain in
      full force and effect during the continuance of this Agreement and
      thereafter in accordance with Section 14.7 hereof, usual and customary
      commercial general liability insurance, which shall include product
      liability coverage.

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9.    ZENTARIS' PATENT RIGHTS

9.1   Spectrum hereby acknowledges that Zentaris is the owner of all of
      Zentaris' Patent Rights and Spectrum shall acquire no rights, title or
      interest whatsoever in or to any of Zentaris' Patent Rights, except as
      specifically provided in the Agreement. Without limiting the generality of
      this Section 9.1, Spectrum shall not utilize any Zentaris' Patent Rights
      for any purpose whatsoever, except as specifically authorized in this
      Agreement. Spectrum shall not register, or attempt to register, any of
      Zentaris' Patent Rights, or otherwise assert any ownership rights with
      respect to any of Zentaris' Patent Rights, in any country within the
      Territory.

9.2   During the term of this Agreement, Zentaris shall be responsible for
      prosecuting the patent applications comprised within the Zentaris' Patent
      Rights and for maintaining the patents comprised within the Zentaris
      Patent Rights. Spectrum shall at Zentaris' request take such actions, and
      shall provide Zentaris with such assistance, as Zentaris shall reasonably
      request in order to protect, perfect, maintain and prosecute Zentaris'
      rights, title and interests in and to all of Zentaris' Patent Rights
      within the Territory. Spectrum shall bear the costs incurred by Zentaris
      in relation to prosecution of the patent applications comprised within
      Zentaris' Patent Rights and in relation to maintenance of the patents
      comprised within Zentaris' Patent Rights, which relate exclusively to
      D-63153 in the Territory.

9.3   Zentaris shall keep Spectrum informed and shall consult with Spectrum on
      an ongoing basis regarding prosecution of the patent applications and
      maintenance of the patents comprised within the Zentaris' Patent Rights
      and any actions which require to be taken in relation thereto. Spectrum
      shall furnish Zentaris with at least thirty (30) days written notice prior
      to the First Commercial Sale of any of the Contract Products in any
      country within the Territory, in order to permit Zentaris to take such
      action as Zentaris, in its sole discretion, determines to be necessary or
      appropriate to protect and perfect Zentaris' rights, title and interests
      in and to all of Zentaris' Patent Rights in that country.

9.4   In the event that Zentaris elects not to continue prosecuting or
      maintaining any of the Zentaris' Patent Rights, Zentaris shall give to
      Spectrum, if possible, sixty (60) days, but in any event not less than
      thirty (30) days, written notice before any relevant deadline relating to
      or any public disclosure of the relevant Zentaris' Patent Rights. Upon
      receipt of a notice from Zentaris indicating that it intends to cease
      prosecuting or maintaining any of the Zentaris' Patent Rights, Spectrum
      shall have the right to continue, at its own expense, prosecution or
      maintenance (as the case may be) of the relevant Zentaris' Patent Rights
      and Zentaris shall at the request and cost of Spectrum do all such acts
      and execute all such documents as may be necessary to (i) transfer title
      to the relevant Zentaris' Patent Rights to Spectrum and (ii) assist
      Spectrum with the prosecution and maintenance of the relevant Zentaris'
      Patent Rights until such times as Spectrum's title as proprietor of the
      relevant Zentaris' Patent Rights has been registered at all of the
      appropriate patent offices.

9.5   Each Party shall furnish the other with timely written notice of any and
      all infringements and other unauthorized uses by any other person, firm,
      corporation or other entity of any of Zentaris' Patent Rights that come to
      its attention during the continuance of this Agreement. Zentaris shall be
      responsible for taking all actions, in

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<PAGE>

      the courts, administrative agencies, or otherwise, including a settlement,
      to prevent or enjoin any and all such infringements and other unauthorized
      uses of Zentaris' Patent Rights, and Spectrum shall take no action with
      respect to any such infringement or unauthorized use of Zentaris' Patent
      Rights, without the prior written authorization of Zentaris; provided,
      however, that Spectrum shall provide at the request and cost of Zentaris
      such assistance as Zentaris shall reasonably request in connection with
      any action to prevent or enjoin any such infringement or unauthorized use
      of any of Zentaris' Patent Rights. In the event Zentaris is unable or
      unwilling to sue the alleged infringer within (i) one hundred twenty (120)
      days of the date of notice of such infringement, or (ii) thirty (30) days
      before the time limit, if any, set forth in the applicable laws and
      regulations for the filing of such actions, whichever comes first, or in
      the event Spectrum requires immediate injunctive relief for breach of its
      exclusive license and Zentaris, after being informed by Spectrum of the
      breach and the proposed action, is unable or unwilling to take such
      immediate action, Spectrum may, but shall not be required to take such
      action as Spectrum may deem appropriate to prevent or enjoin the alleged
      infringement or threatened infringement of a Zentaris' Patent Right. In
      such event, Spectrum shall act at its own expense, and Zentaris shall
      co-operate reasonably with Spectrum, at the expense of Spectrum, and
      Zentaris agrees to be named as a nominal party. In the event of such
      action by Spectrum, any recovery obtained shall be paid to Spectrum.

10.   JOINT PATENT RIGHTS TO JOINT RESULTS

10.1  All patentable Inventions created, generated, conceived, made, developed,
      or reduced to practice jointly by Spectrum and Zentaris (including their
      Affiliates or other persons or entities on behalf of Spectrum and
      Zentaris) as a result of the work performed under this Agreement shall be
      the joint property of Spectrum and Zentaris each of whom shall have a
      one-half pro indiviso share. Neither Party shall assign or transfer their
      respective shares in any such jointly owned patentable Inventions or in
      any patent applications filed therefore or in any patent granted in
      respect of any such jointly owned patentable Inventions (all together the
      "Joint Patent Rights") to any Third Party without the other Party's prior
      written consent.

10.2  The Parties will decide on a case by case basis which Party will have the
      responsibility for handling the filing, prosecution and maintenance of any
      Joint Patent Rights. Unless agreed otherwise, the Parties will equally
      bear the costs of such filing, prosecution and maintenance of Joint Patent
      Rights. In making such a decision, the principles observed by the Parties
      will be the relative contributions of each Party to the joint Invention,
      the standards and customs in the industry and expected efficiency in
      patenting procedures.

10.3  Joint Patent Rights shall be filed in the name of both Parties and each
      Party shall procure that its respective inventors assign all of their
      rights and interests to such Joint Patent Rights to both Parties. Each
      Party shall be free to use and exploit the Joint Patent Rights for any
      purpose whatsoever. Neither Party shall grant licenses of the Joint Patent
      Rights to any Third Party without the other Party's prior written consent
      and on terms and conditions to be agreed with the other Party acting
      reasonably.

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10.4  In each case, whichever Party files, prosecutes, and maintains the Joint
      Patent Rights ("Prosecuting Party") shall keep the other Party informed of
      the filings, prosecution, and maintenance reasonably in advance of any
      relevant actions and deadlines to allow for review and consultation. In
      the event that the Prosecuting Party elects not to continue prosecuting or
      maintaining any of the Joint Patent Rights, the Prosecuting Party shall
      give to the other Party, if possible, sixty (60) days, but in any event
      not less than thirty (30) days, written notice before any relevant
      deadline relating to or any public disclosure of the relevant Joint Patent
      Rights. Upon receipt of a notice from the Prosecuting Party indicating
      that it intends to cease prosecuting or maintaining any of the Joint
      Patent Rights, the other Party shall have the right to continue, at its
      own expense, prosecution or maintenance (as the case may be) of the
      relevant patent rights and to request the assignment of such right. The
      Prosecuting Party shall at the request and cost of the other Party do all
      such acts and execute all such documents as may be necessary to assist the
      other Party with the prosecution or maintenance of such patent right as
      well as with the assignment and transfer of such patent right to the other
      Party.

11.   EXCHANGE OF SAFETY INFORMATION

11.1  The Parties shall keep each other informed on all reports including
      publications of adverse events coming to either Party's knowledge with
      regard to Contract Products and/or D-63153, regardless of the origin of
      such reports.

11.2  Each Party will report all serious adverse events with a reasonable
      suspicion of causal relationship (suspected adverse drug reactions)
      occurring in clinical trials under the use of the Contract Products to the
      other Party within ten (10) business days after they come to the attention
      of that Party. In the event of fatal or life-threatening situations
      related to the Contract Products, adverse events will be reported to the
      other Party within five (5) business days after they come to the attention
      of that Party. Details of an exchange of safety information will be agreed
      separately between the Parties after the Effective Date, which agreement
      should adhere to the standards required by the appropriate regulatory
      agencies.

11.3  Each Party is responsible for submitting its own Periodic Safety Update
      Reports in accordance with the applicable guidelines including the "Notice
      to Marketing Authorization Holders: Pharmacovigilance Guidelines" and the
      ICH E2C Guidelines "Clinical Safety Data Management: Periodic Safety
      Update Reports for Marketed Drugs" and will provide a copy of each such
      Periodic Safety Update Report to the other Party. When data received from
      the other Party might contribute meaningfully to the safety analysis and
      influence any proposed or effected changes in the reporting marketing
      authorization holder's product information, these data should be included,
      with source indicated and discussed in the Periodic Safety Update Reports.

12.   CONFIDENTIALITY INFORMATION

12.1  All Confidential Information disclosed, revealed or otherwise made
      available by one Party ("Disclosing Party") to the other Party ("Receiving
      Party") under, or as a result of, this Agreement is furnished to the
      Receiving Party solely to permit the Receiving

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<PAGE>

      Party to exercise its rights, and perform its obligations, under this
      Agreement. The Receiving Party shall not use any of the Disclosing Party's
      Confidential Information for any other purpose, and shall not disclose,
      reveal or otherwise make any of the Disclosing Party's Confidential
      Information available to any other person, firm, corporation or other
      entity, without the prior written authorization of the Disclosing Party.

12.2  In furtherance of the Receiving Party's obligations under Section 12.1
      hereof, the Receiving Party shall take all appropriate steps, and shall
      implement all appropriate safeguards, to prevent the unauthorized use or
      disclosure of any of the Disclosing Party's Confidential Information.
      Without limiting the generality of this Section 12.2, the Receiving Party
      shall disclose any of the Disclosing Party's Confidential Information only
      to those of its officers, employees, agents, consultants, directors,
      Licensees, sublicensees, potential sublicensees and financial investors
      that have a need to know the Disclosing Party's Confidential Information,
      in order for the Receiving Party to exercise its rights and perform its
      obligations under this Agreement, and only if such officers, employees,
      agents, consultants, directors, Licensees, sublicensees, potential
      sublicensees and financial investors have executed appropriate
      non-disclosure agreements containing substantially similar terms regarding
      confidentiality as those set out in this Agreement or are otherwise bound
      by obligations of confidentiality effectively prohibiting the unauthorized
      use or disclosure of the Disclosing Party's Confidential Information. The
      Receiving Party shall furnish the Disclosing Party with immediate written
      notice of any unauthorized use or disclosure of any of the Disclosing
      Party's Confidential Information by any officer, employee, agents,
      consultants, directors, licensee or sublicensee of the Receiving Party,
      and shall take all actions that the Disclosing Party reasonably requests
      in order to prevent any further unauthorized use or disclosure of the
      Disclosing Party's Confidential Information.

12.3  The Receiving Party's obligations under Sections 12.1 and 12.2 hereof
      shall not apply to the extent, but only to the extent, that any of the
      Disclosing Party's Confidential Information:

      (i)   passes into the public domain, or becomes generally available to the
            public through no fault of the Receiving Party;

      (ii)  was known to the Receiving Party prior to disclosure hereunder by
            the Disclosing Party;

      (iii) is disclosed, revealed or otherwise made available to the Receiving
            Party by a Third Party that is under no obligation of non-disclosure
            and/or non-use to the Disclosing Party;

      (iv)  is required to be disclosed under applicable law or by court order,
            or in connection with any application by the Receiving Party for any
            Regulatory Approvals; provided, however, that the Receiving Party
            shall furnish the Disclosing Party's with as much prior written
            notice of such disclosure requirement as reasonably practicable, so
            as to permit the Disclosing Party, in its sole discretion, to take
            appropriate action, including seeking a protective order, in order
            to prevent the Disclosing Party's Confidential Information from
            passing into the public domain or becoming generally available to
            the public; or

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      (v)   is independently developed by the Receiving Party without breach of
            this Agreement as evidenced by contemporaneous written records.

12.4  Subject to Section 15, upon expiration or termination of this Agreement
      for any reason whatsoever, the Receiving Party shall return to the
      Disclosing Party, or destroy, as the Disclosing Party shall specify in
      writing, all copies of all documents and other materials that contain or
      embody any of the Disclosing Party's Confidential Information, except to
      the extent that the Receiving Party is required by applicable law to
      retain such documents and materials. Within thirty (30) days after the
      date of expiration or termination of this Agreement, the Receiving Party
      shall furnish the Disclosing Party with a certificate, duly executed by an
      officer of the Receiving Party, confirming that the Receiving Party has
      complied with it obligations under this Section 12.4.

12.5  All of the Receiving Party's obligations under Sections 12.1 and 12.2
      hereof, with respect to the protection of the Disclosing Party's
      Confidential Information, shall survive the expiration or termination of
      this Agreement for any reason whatsoever.

13.   WARRANTIES AND LIABILITIES OF ZENTARIS

      Zentaris warrants and represents as follows:

13.1  As of the Effective Date, the LHRH Patents are in compliance with all
      legal requirements in the United States regarding the filing, examination,
      and maintenance fees. To Zentaris' present knowledge, as of the Effective
      Date, all Zentaris Patent Rights are in compliance with all legal
      requirements regarding the filing, examination, and maintenance fees. The
      above shall not apply to a requirement that, if not satisfied, would not
      result in a revocation or lapse or otherwise adversely affect the
      enforceability of the patents in question. To Zentaris' present knowledge,
      Zentaris has not taken any action or, failed to take any action (including
      a failure to disclose material prior art in connection with the
      prosecution of any patent), or used or enforced or, failed to use or
      enforce any of the Zentaris' Patents Rights in a manner that would result
      in the abandonment or unenforceability of any of the Zentaris' Patents
      Rights.

13.2  As of the Effective Date, no LHRH Patents have been or are now involved in
      any interference, reissue, reexamination or opposing proceeding in the
      United States Patent and Trademark Office or any equivalent authority in
      Canada. To Zentaris' present knowledge, as of the Effective Date, no
      Zentaris Patents Rights have been or are now involved in any interference,
      reissue, reexamination or opposing proceeding in any jurisdiction within
      the Territory. To Zentaris' present knowledge, no such action has been
      threatened. To Zentaris' present knowledge, other than US Patent number
      [Intentionally Redacted], there is no patent of any person that claims the
      same

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      subject matter as the LHRH Patents, and Zentaris is not aware of any prior
      art that invalidates any claim of any LHRH Patents for use in the Initial
      Indications. Spectrum confirms that it is aware of the International
      Search Reports issued by the International Searching Authority for
      [Intentionally Redacted].

13.3  Zentaris is the owner of all right, title and interest in and to all of
      the Zentaris Patents Rights. The LHRH Patents are free and clear of any
      and all encumbrances, covenants, conditions and restrictions or, other
      adverse claims or interests of any kind or nature, and Zentaris has not
      received any written notice or claim or, any oral notice or claim,
      challenging Zentaris' complete and exclusive ownership of the LHRH Patents
      or suggesting that any other person has any claim of legal or beneficial
      ownership with respect thereto, and there is no agreement, decree,
      arbitral award or other provision or contingency which obligates Zentaris
      to grant licenses in the LHRH Patents. To Zentaris' present knowledge, the
      warranties of this Section 13.3 shall also apply to all other Zentaris
      Patents Rights.

13.4  To Zentaris' present knowledge, Zentaris owns or possesses adequate
      licenses or other rights to use all of the Zentaris' Patents Rights
      necessary to develop, make, have made, use, sell, offer for sale, have
      sold, import and export and commercialize Contract Products and /or D -
      63153 in the Field and in the Territory.

13.5  To Zentaris' present knowledge, the use of the Zentaris' Patents Rights to
      develop, make, have made, use, sell, offer for sale, have sold, import and
      export and commercialize Contract Products and/or D-63153 in the Field and
      in the Territory, would not infringe upon, violate or constitute the
      unauthorized use of any rights owned or controlled by any Third Party,
      including any Patent of any Third Party. No litigation is now pending and
      no notice or other claim has been received by Zentaris, (A) alleging that
      Zentaris has engaged in any activity or conduct that infringes upon,
      violates or constitutes the unauthorized use of the Patents of any Third
      Party, or (B) challenging the ownership, use, validity or enforceability
      of the LHRH Patents. To Zentaris' present knowledge, no litigation is now
      pending challenging the ownership, use, validity or enforceability of the
      Zentaris' Patent Rights.

13.6  To Zentaris' present knowledge, no Third Party is misappropriating,
      infringing, diluting or violating any Zentaris' Patent Rights, and no
      claims for any of the foregoing have been brought against any Third Party
      by Zentaris. Zentaris has taken reasonable steps in accordance with normal
      industry practice to protect its Zentaris' Patent Rights.

13.7  Zentaris has experience as an investor in securities of companies and
      acknowledges that it can bear the economic risk of its investment in the
      Initial Shares and [Intentionally Redacted] issuable to Zentaris pursuant
      to the terms of this Agreement. Zentaris either (a) has a pre-existing
      personal or business relationship with Spectrum or any of its officers,
      directors or controlling persons that is of a nature and duration which
      enables Zentaris to be aware of the character, business acumen and general
      business and financial circumstances of Spectrum or (b) by reason of its
      business or financial expertise or the business or financial experience of
      its professional advisors who are unaffiliated with

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      and who are not compensated by Spectrum or any affiliate or selling agent
      of Spectrum, directly or indirectly, has the capacity to protect its own
      interests in connection with its acquisition of the Shares. Zentaris is an
      "accredited investor" as defined under Rule 501(a) of the Securities Act
      of 1933, as amended (the "Securities Act").

13.8  The Shares to be acquired by Zentaris will be acquired for investment for
      Zentaris' own account not as a nominee or agent, and not with a view to
      the resale or distribution of any part thereof, and Zentaris has no
      present intention of selling, granting any participation in, or otherwise
      distributing the same. Zentaris does not presently have any contract,
      undertaking, agreement or arrangement with any person or entity to sell,
      transfer or grant participations to such person or entity or to any third
      person or entity, with respect to any of the Shares. Zentaris has not been
      formed for the specific purpose of acquiring solely the Shares.

13.9  Zentaris has received and reviewed information about Spectrum and has had
      an opportunity to discuss Spectrum's business, management and financial
      affairs with its management and to review Spectrum's facilities in order
      to reach an informed and knowledgeable decision to acquire the Shares.
      Zentaris understands and acknowledges that such discussions, as well as
      any written information issued by Spectrum (i) were intended to describe
      the aspects of Spectrum's business and prospects which Spectrum believes
      to be material, but were not necessarily an exhaustive description, and
      (ii) may have contained forward-looking statements involving known and
      unknown risks and uncertainties which may cause Spectrum's actual results
      in future periods or plans for future periods to differ materially from
      what was anticipated and that no representations or warranties were or are
      being made with respect to any such forward-looking statements or the
      probability of achieving any of the results projected in any of such
      forward-looking statements.

13.10 Zentaris understands that the Shares will be issued without registration
      under the Securities Act and without qualification and/or registration
      under applicable state securities laws ("Blue Sky Laws"), in reliance upon
      specific exemptions there from, which exemptions depend upon, among other
      things, the bona fide nature of the investment intent and the accuracy of
      Zentaris' representations as expressed herein. Zentaris understands that
      the Shares are "restricted securities" under applicable U.S. federal and
      state securities laws and that, pursuant to these laws, Zentaris must hold
      the Shares indefinitely unless they are registered with the SEC and
      qualified by state authorities, or an exemption from such registration and
      qualification requirements is available. Moreover, Zentaris understands
      that Spectrum is under no obligation to register and/or qualify the
      Initial Shares. In addition, Zentaris acknowledges that if an exemption
      from registration or qualification is available, it may be conditioned on
      various requirements including, but not limited to, the time and manner of
      sale, the holding period for the Shares, and on requirements relating to
      Spectrum which are outside of Zentaris' control, and which Spectrum is
      under no obligation and may not be able to satisfy. Zentaris acknowledges
      that Spectrum will make a notation on its stock books regarding the
      restrictions on transfers set forth in this section and will transfer
      securities on the books of Spectrum only to the extent not inconsistent
      therewith.

                                                                              22
<PAGE>

13.11 Without in any way limiting the provisions of Section 13.10 above,
      Zentaris agrees not to make any disposition of all or any portion of the
      Shares unless and until any of the following conditions apply: (a) there
      is then in effect a registration statement under the Securities Act
      covering such proposed disposition and the disposition is made in
      accordance with such registration statement; or (b) (i) Zentaris shall
      have notified Spectrum of the proposed disposition and shall have
      furnished Spectrum with a statement of the circumstances surrounding the
      proposed disposition and (ii) if reasonably requested by Spectrum,
      Zentaris shall have furnished Spectrum with an opinion of counsel,
      reasonably acceptable to Spectrum, that such disposition will not require
      registration under the Securities Act.

13.12 Zentaris understands that the Shares, and any securities issued in respect
      of or exchange for the Shares, may bear one or all of the following
      legends until they are no longer required by law or the provisions of this
      Agreement:

      (i)   "THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN
            REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
            "SECURITIES ACT"), WITH THE SECURITIES AND EXCHANGE COMMISSION OR
            THE SECURITIES COMMISSION OF ANY STATE, AND, ACCORDINGLY, MAY NOT BE
            OFFERED, SOLD OR TRANSFERRED EXCEPT PURSUANT TO AN EFFECTIVE
            REGISTRATION STATEMENT UNDER THE SECURITIES ACT OR PURSUANT TO AN
            AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS THEREUNDER
            AND IN COMPLIANCE WITH APPLICABLE STATE SECURITIES OR BLUE SAY LAWS.
            NO HEDGING TRANSACTIONS INVOLVING THESE SECURITIES MAY BE CONDUCTED
            EXCEPT IN COMPLIANCE WITH THE SECURITIES ACT."

      (ii)  Any legend required by the Blue Sky laws of any state to the extent
            such laws are applicable to the shares represented by the
            certificate so legended.

      (iii) The legend set forth above shall be removed by Spectrum from any
            certificate evidencing Shares upon transfer of such Shares in
            compliance with Rule 144 under the Securities Act or upon delivery
            to Spectrum of an opinion, in form and substance and by counsel
            reasonably satisfactory to Spectrum, that a registration statement
            under the Securities Act is at that time in effect with respect to
            the legended security or that such security can be freely
            transferred without such a registration statement being in effect
            and that such transfer will not jeopardize the exemption or
            exemptions from registration pursuant to which the securities were
            issued.

13.13 Zentaris acknowledges and agrees that Spectrum makes no representation
      with respect to observance of the laws of Zentaris' jurisdiction in
      connection with any invitation to subscribe for the Shares, including (i)
      the legal requirements within its jurisdiction for the purchase of the
      Shares, (ii) any foreign exchange restrictions applicable to such
      purchase, (iii) any governmental or other consents that may need to be
      obtained, and (iv) the income tax and other tax consequences to Zentaris,
      if any, that may be relevant to the purchase, holding, redemption, sale,
      or transfer of the Shares, and Zentaris acknowledges and agrees that
      Spectrum shall have no responsibility for any

                                                                              23
<PAGE>

      effects of such laws on Zentaris as a result of Zentaris' subscription and
      payment for and continued beneficial ownership of the Shares.

13.14 Zentaris makes no representation or warranty and specifically disclaims
      any guarantee that the development of Contract Products and/or D - 63153
      will be successful, in whole or in part, or that the Zentaris' Patent
      Rights and Zentaris' Know-How will be suitable for commercialization.
      Zentaris expressly disclaims any warranties or conditions, express,
      implied, statutory or otherwise with respect to Zentaris' Patent Rights
      and Zentaris' Know-How, including without limitation, any warranty or
      merchantability of fitness for a particular purpose or non-infringement.

13.15 Zentaris, as a condition to receiving the [Intentionally Redacted], agrees
      to provide the above representations and warranties in Sections 13.7
      through 13.13 as of the Submission Date.

13.16 Zentaris is a corporation duly organized, validly existing and in good
      standing under the laws of its jurisdiction of formation.

13.17 Zentaris has the absolute and unrestricted right, power, authority, and
      capacity to execute and deliver this Agreement and to perform its
      obligations under this Agreement, which actions have been duly and validly
      authorized and approved by all necessary corporate action of Zentaris.

13A.  WARRANTIES AND LIABILITIES OF SPECTRUM

      Spectrum warrants and represents as follows:

13A.1 Spectrum is aware of the patent USP number [Intentionally Redacted] and
      corresponding patents.

13A.2 Spectrum's most recent annual report on Form 10-K and quarterly report on
      Form 10-Q as on file with the SEC are accurate and complete in all
      material respects and since the date of its most recent Annual Report on
      Form 10-K no event has occurred or circumstance existed that has had, or
      is reasonably expected to cause, a Material Adverse Effect on Spectrum. A
      "Material Adverse Effect" for purposes of this Section 13A means any
      effect or change that would be (or could be reasonably expected to be)
      materially adverse to the business, assets, financial condition or
      operating results of Spectrum, excluding any adverse change, event,
      development, or effect arising from or relating to (a) general business or
      economic conditions, including such conditions related to the business of
      Spectrum, (b) national or international political or social conditions,
      including the engagement by the United States in hostilities, whether or
      not pursuant to the declaration of a national emergency or war, or the
      occurrence of any military or terrorist attack upon the United States, or
      any of its territories, possessions, or diplomatic or consular offices or
      upon any military installation, equipment or personnel of the United
      States, (c) financial, banking, or securities markets (including any
      disruption thereof or any decline in the price of

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      securities generally or any market or index), (d) changes in United States
      generally accepted accounting principles, and (e) changes in law, rules,
      regulations, orders, or other binding directives issued by any government
      entity.

13A.3 Spectrum is a corporation duly organized, validly existing and in good
      standing under the laws of its jurisdiction of formation. Spectrum has
      full corporate power and authority to conduct its business as it is now
      being conducted and to own or use the properties and assets that it
      purports to own or use. Spectrum is duly qualified and in good standing to
      do business in each jurisdiction in which such qualification is necessary
      because of the nature of the business conducted by it except where the
      failure to be so qualified would not reasonably be expected to have a
      Material Adverse Effect.

13A.4 Spectrum has the absolute and unrestricted right, power, authority, and
      capacity to execute and deliver this Agreement and to perform its
      obligations under this Agreement, which actions have been duly and validly
      authorized and approved by all necessary corporate action of Spectrum.

13A.5 When issued in accordance with the provisions of this Agreement, the
      Shares will be duly and validly issued, fully paid, and non-assessable,
      and to Spectrum's present knowledge, will be free of restrictions on
      transfer other than the restrictions set forth or referred to in Sections
      4.1 and 13 of this Agreement.

14.   INDEMNIFICATION AND INSURANCE

14.1  Zentaris shall defend, indemnify and hold Spectrum harmless against any
      Third Party claims, suits, actions, proceedings, losses, liabilities,
      damages, costs and expenses (collectively "Claims and Liabilities")
      arising from, related to, or attributable to:

      (i)   any breach of any of Zentaris' representations, warranties or
            covenants set forth in this Agreement; and

      (ii)  any other negligent, willful or intentionally wrongful act, error or
            omission on the part of Zentaris, or any officer, director,
            employee, agent or representative of Zentaris.

      Zentaris' indemnification obligation under this Section 14.1 shall be
      subject to each of the following conditions: (i) Spectrum shall furnish
      Zentaris with written notice of any such Claims and Liabilities within
      thirty (30) days of the date on which Spectrum receives notice thereof;
      (ii) Zentaris shall be solely responsible for the investigation, defense,
      settlement and discharge of such Claims and Liabilities (provided that
      such settlement does not impose any material obligation on the indemnitee
      or the other Party); and (iii) Spectrum shall at Zentaris' cost furnish
      Zentaris with all assistance reasonably requested by Zentaris in
      connection with the investigation, defense, settlement and discharge of
      such Claims and Liabilities. Spectrum's failure to comply with its
      obligations pursuant to this Section 14.1 shall not constitute a breach of
      this Agreement or relieve Zentaris of its indemnification obligations
      pursuant to this Section 14.1, except to the extent, if any, that
      Zentaris' defense of the effective claim, action or proceeding actually
      was materially impaired thereby.

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<PAGE>

14.2  In the event that it is determined by any court of competent jurisdiction
      that Spectrum's use of Zentaris' Patent Rights and/or Zentaris' know-How
      Spectrum's use of Zentaris' Patent Rights and/or Zentaris' Know-How in
      accordance with the terms and conditions of this Agreement infringes, or
      Zentaris reasonably determines that Spectrum's use of Zentaris' Patent
      Rights and/or Zentaris' Know-How is likely to infringe any Intellectual
      Property Right of a Third Party, Zentaris shall in consultation with
      Spectrum use commercially reasonable efforts to (i) procure at Zentaris'
      expense a license from such Third Party authorizing Spectrum to continue
      to utilize Zentaris' Patent Rights; or (ii) modify the Zentaris' Know-How,
      so as to render it non-infringing. In the event that neither of the
      foregoing alternatives is reasonably available or commercially feasible,
      Spectrum may at its option either cease using the Zentaris' Patent Rights
      and/or Zentaris' Know-How for so long as and to the extent that such
      Zentaris' Patent Rights and/or Zentaris' Know-How are infringing the
      relevant Third Party rights or terminate the rights and licenses granted
      to Spectrum solely with respect to that county or those countries in which
      the infringement of Third Party rights has occurred or is likely to occur.

14.3  Zentaris' obligations under Sections 14.1 and 14.2 hereof shall not apply
      to any allegations of infringement of the intellectual property rights of
      another person, firm, corporation or other entity that would not have
      arisen but for: (i) Spectrum's use of Zentaris' Patent Rights and/or
      Zentaris' Know-How in violation of the terms and conditions of this
      Agreement; (ii) any modification, adaptation or application of Zentaris'
      Know-How made by Spectrum without the prior authorization of Zentaris; or
      (iii) any combination of the Contract Products with any other products,
      compounds or materials but only if the allegation of infringement does not
      relate to D-63153.

14.4  Spectrum shall defend, indemnify and hold Zentaris harmless against any
      and all Claims and Liabilities arising from, related to, or attributable
      to:

      (i)   any claim, including any product liability claim, by any Third Party
            with respect to any of the Contract Products regardless of whether
            such claim is based on contract, breach of warranty, any form of
            tort, strict liability, or otherwise;

      (ii)  any allegation that any of the Contract Products fail to conform
            with the requirements of any applicable laws and/or any applicable
            Regulatory Approvals, including, but not limited to, the failure by
            Spectrum to obtain any required Regulatory Approvals for the
            Contract Products;

      (iii) any breach of any of Spectrum's representations, warranties or
            covenants set forth in this Agreement; or

      (iv)  any other negligent, willful or intentionally wrongful act, error or
            omission on the part of Spectrum, or any officer, director,
            employee, agent or representative of Spectrum.

      Spectrum's indemnification obligation under this Section 14.4 shall be
      subject to each of the following conditions: (i) Zentaris shall provide
      Spectrum with written notice of any such Claims and Liabilities within
      thirty (30) days after Zentaris receives notice

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<PAGE>

      of such Claims and Liabilities; (ii) subject to Spectrum confirming in
      writing that the indemnity will apply to the relevant Claims and
      Liabilities, Spectrum shall be solely responsible for the investigation,
      defense, settlement and discharge of such Claims and Liabilities (provided
      that such settlement does not impose any material obligation on the
      indemnitee or the other Party); and (iii) Zentaris shall at Spectrum's
      cost furnish Spectrum with all assistance reasonably requested by Spectrum
      in connection with the investigation, defense, settlement and discharge of
      such Claims and Liabilities. Zentaris' failure to comply with its
      obligations pursuant to this Section 14.4 shall not constitute a breach of
      this Agreement or relief Spectrum of its indemnification obligations
      pursuant to this Section 14.4, except to the extent, if any, that
      Spectrum's defense of the effective claim, action or proceeding actually
      was materially impaired thereby.

14.5  Spectrum shall, at its sole cost and expense, obtain no later than on the
      date of First Commercial Sale of the Contract Products in any country
      within the Territory, and shall maintain in full force and effect during
      the continuance of this Agreement and thereafter in accordance with
      Section 14.7 hereof, usual and customary commercial general liability
      insurance, which shall include product liability coverage.

14.6  Spectrum shall, if possible, and, if any additional expense is involved,
      subject to reaching agreement with Zentaris' as to which Party shall bear
      the costs thereof, cause Zentaris and Zentaris' licensees to be named as
      additional insured under Spectrum's commercial general liability insurance
      policies under Section 14.5 hereof. Each such commercial general liability
      insurance policy obtained and maintained by Spectrum under Section 14.5
      shall provide for at least thirty (30) days written notice to Zentaris and
      Zentaris' licensors prior to cancellation, non-renewal or material change
      in such insurance policy. In the event of cancellation or non-renewal of
      any such commercial general liability insurance policy, Spectrum shall, at
      its sole cost and expense, obtain replacement insurance coverage, in
      accordance with the requirements of Section 14.5 hereof, prior to the
      effective date of such cancellation or non-renewal.

14.7  Zentaris' indemnification obligation under Section 14.1 hereof and
      Zentaris' obligation to maintain commercial general liability insurance
      under Section 8.7 hereof, Spectrum's indemnification obligation under
      Section 14.4 hereof, and Spectrum's obligation to maintain commercial
      general liability insurance under Section 14.5 hereof, shall survive the
      expiration or termination of this Agreement for any reason whatsoever for
      a period of five (5) years after the date of expiration or termination
      hereof.

14.8  Zentaris' liability in case of simple negligence shall be excluded. Except
      in case of willful misconduct, Zentaris shall not be liable to Spectrum
      for any indirect, punitive or consequential damages, whether based on
      contract or tort, or arising under applicable law or otherwise.
      [Intentionally Redacted].

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15.   TERM AND TERMINATION

15.1  This Agreement shall enter into effect on the Effective Date, and shall
      remain in full force and effect for a period of ten (10) years from the
      First Commercial Sale of the Contract Products in any country within the
      Territory or as long as any Contract Product is covered by a valid claim
      of a Zentaris' Patent Right in the Territory, whichever term is longer.

15.2  In the event that either Party (the "Breaching Party") commits a material
      breach or default of any of its obligations hereunder, such material
      breach to include, but not to be limited to, a material breach of the
      obligations under Section 3.1 above, the other Party hereto (the
      "Non-Breaching Party") may give the Breaching Party written notice of such
      material breach or default, and shall request that such material breach or
      default be cured as soon as reasonably practicable. In the event that the
      Breaching Party fails to cure such material breach or default within
      ninety (90) days after the date of the Non-breaching Party's notice
      thereof, the Non-Breaching Party may terminate this Agreement as a whole
      or on an Indication-by-Indication basis by giving written notice of
      termination to the Breaching Party. Termination of this Agreement in
      accordance with this Section 15.2 shall not affect or impair the
      Non-Breaching Party's right to pursue any legal remedy, including, but not
      limited to, the right to recover damages, for any harm suffered or
      incurred by the Non-Breaching Party as a result of such material breach or
      default. For purposes of this Agreement, it is not a "material breach" of
      this Agreement by Spectrum if the development is delayed due to the
      following: (i) scientific, medical or technical reasons; (ii)
      circumstances that are beyond the control of Spectrum; or (iii) the fault
      of Zentaris.

15.3  In addition to the termination rights provided for in Section 15.2 hereof,
      each Party shall have the right to terminate this Agreement, immediately
      by giving written notice of termination to the other Party, if the other
      Party files a voluntary petition, or if an involuntary petition is granted
      in respect of the other Party and appeal proceedings are not commenced
      within a period of seven (7) days from the date of such petition under the
      bankruptcy provisions of applicable law, or the other Party is declared
      insolvent, undergoes voluntary or involuntary dissolution, or makes an
      assignment for the benefit of its creditors, or fails or is unable to pay
      its debts as they come due, or suffers the appointment of a receiver or
      trustee over all, or substantially all, of its assets or properties.

15.4  Notwithstanding any other provision of this Agreement, Spectrum shall have
      the right to terminate this Agreement in its entirety or with respect to
      any particular Contract Product and/or country in the Territory, at any
      time upon sixty (60) days' notice to Zentaris.

15.5  Except as set out in Section 15.10 hereof, immediately upon the expiration
      or termination of this Agreement for any reason whatsoever, Spectrum shall
      cease all distribution, marketing and sale of the Contract Products under
      the licenses granted hereunder; provided, however, that, if this Agreement
      is terminated for any reason other than a breach or default hereunder by
      Spectrum, Spectrum shall have the right to distribute and sell its
      existing inventory of the Contract Products for a period of not more than
      one hundred and twenty (120) days following the date of expiration or
      termination hereof, subject to Spectrum's continuing obligation to pay
      royalties with respect to the Net Sales derived from the distribution and
      sale of such existing

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<PAGE>

      inventory of the Contract Products, in accordance with the requirements of
      Section 4.5 hereof.

15.6  Termination of this Agreement for any reason whatsoever shall not relieve
      Spectrum of its obligations: (i) to pay all royalties and other amounts
      payable to Zentaris which have accrued prior to, but remain unpaid as of,
      the date of expiration or termination hereof, or which accrue thereafter,
      in accordance with Section 15.5 hereof; (ii) to defend, indemnify and hold
      Zentaris, its licensors and their respective officers, directors,
      shareholders, employees, agents and representatives harmless against
      claims and liabilities, as provided in Section 14.4 hereof; and (iii) to
      maintain commercial general liability insurance coverage, in accordance
      with the requirements of Sections 14.5 and 14.6 hereof. In addition,
      termination of this Agreement for any reason whatsoever shall not relieve
      Zentaris of its obligations (i) to defend, indemnify and hold Spectrum,
      its licensors and their respective officers, directors, shareholders,
      employees, agents and representatives harmless against claims and
      liabilities, as provided in Section 14.1 hereof, or any other surviving
      obligations, and (ii) to maintain commercial general liability insurance
      coverage, in accordance with the requirements of Section 8.7

15.7  Except in the case of termination of this Agreement by Spectrum under
      Sections 15.2 or 15.3, the expiration or termination of this Agreement
      shall not adversely affect or impair Zentaris' right to continue to use
      any and all Improvements licensed by Spectrum to Zentaris under Section
      7.4 hereof. Except as otherwise specifically provided in this Agreement,
      upon expiration or termination of this Agreement for any reason
      whatsoever, Zentaris shall have no further obligations to Spectrum
      hereunder.

15.8  Except in the case of termination of this Agreement by Zentaris under
      Sections 15.2 or 15.3, the expiration or termination of this Agreement
      shall not adversely affect or impair Spectrum's right to continue to use
      any and all Improvements licensed by Zentaris to Spectrum under Section
      7.2 hereof. Except as otherwise specifically provided in this Agreement,
      upon expiration or termination of this Agreement for any reason
      whatsoever, Spectrum shall have no further obligations to Zentaris
      hereunder.

15.9  In the event of termination of this Agreement by Zentaris pursuant to
      Sections 15.2 or 15.3 or by Spectrum pursuant to Sections 15.4, Zentaris
      shall have the right to use all the Development Data in the Field and in
      the Territory and to demand from Spectrum the transfer of Regulatory
      Approvals for the territory concerned to Zentaris or a person or company
      named by Zentaris within ninety (90) days after the termination date
      against payment of all external costs which Spectrum incurred in
      connection with obtaining the Regulatory Approvals to be transferred. If
      Regulatory Approvals have not been obtained by Spectrum, Zentaris may
      claim from Spectrum that Spectrum transfers to Zentaris the status of an
      applicant for the Regulatory Approvals and notifies the competent
      regulatory authority thereof and supplies Zentaris with all documents
      already prepared by Spectrum for the filing of applications for Regulatory
      Approvals.

15.10 In the event of termination of this Agreement by Spectrum pursuant to
      Sections 15.2 or 15.3, the license rights contained in Sections 2.1 and
      2.2 shall continue in full force and effect, Spectrum's obligations under
      Sections 4 to 10 hereof shall terminate and from the date of such
      termination the participation payment and the royalty rates set

                                                                              29
<PAGE>

      out in Sections 4.3 and 4.5 will be reduced by [Intentionally Redacted]
      percent ([Intentionally Redacted]%).

15.11 Notwithstanding the foregoing, in the event of any termination of this
      Agreement by Spectrum pursuant to Sections 15.2 or 15.4 or by Zentaris
      pursuant to Section 15.2 with respect to fewer than all of the Contract
      Products and/or fewer than all of the countries in the Territory, the
      Development Data and/or Regulatory Approvals to be transferred, granted
      and otherwise assigned to Zentaris under Section 15.9 shall be expressly
      limited to those pertaining to the Contract Products and/or the countries
      in the Territory to which such termination applies.

16.   GENERAL PROVISIONS

16.1  ASSIGNMENT

      Subject to the other terms of this Agreement, neither Party shall have the
      right or the power to assign any of its rights, or delegate or subcontract
      the performance of any of its obligations under this Agreement, without
      the prior written authorization of the other Party, such written
      authorization not to be unreasonably withheld or delayed; provided,
      however, that the prior written authorization of the other Party shall not
      be required for a Party to assign any of its rights, or delegate or
      subcontract the performance of any of its obligations hereunder to an
      Affiliate or pursuant to a sale of substantially all of the assets of the
      Party, merger, consolidation, reorganization or other similar transaction.
      Any permitted assignment or delegation hereunder by either Party, whether
      to an Affiliate or pursuant to a sale of substantially all of the assets
      of the Party, merger, consolidation, reorganization or other similar
      transaction pursuant to this Section 16.1, or pursuant to the prior
      written authorization of the other Party, shall not relieve such Party of
      any of its obligations under this Agreement, including, but not limited
      to, the Party's obligation to make royalty payments with respect to any
      and all Net Sales derived by any of the Party's assignees or sublicensees
      from the distribution, marketing and sale of any of the Contract Products.

16.2  FORCE MAJEURE

      Neither Party shall be liable for any failure to perform, or any delay in
      the performance of, any of its obligations under this Agreement to the
      extent, but only to the extent, that such Party's performance is prevented
      by the occurrence of an event of force majeure. For purposes of this
      Section 16.2, an event of force majeure shall mean and include, war, civil
      war, insurrection, rebellion, civil unrest, fire, flood, earthquake,
      adverse weather conditions, strike, lockout, labor unrest, unavailability
      of supplies, materials or transportation, acts of the public enemy, acts
      of government authorities, and, in general, any other cause or condition
      beyond the reasonable control of the party whose performance is affected
      thereby. In the event that a Party's performance is affected by the
      occurrence of any event of force majeure, that Party shall furnish
      immediate written notice thereof to the other Party hereto.

16.3  NOTICES

      All notices, reports and other communications between the Parties under
      this

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                                                                              30
<PAGE>

      Agreement shall be sent by registered air mail, postage prepaid and return
      receipt requested, by international air courier, or by facsimile, with a
      confirmation copy sent by registered air mail or international air
      courier, addressed as follows:

      To: Zentaris                          Zentaris GmbH
                                            Weismullerstrasse 45
                                            D-60314 Frankfurt/Main
                                            Germany
                                            Attention:________________________
                                            Facsimile:________________________

      To: Spectrum                          Spectrum Pharmaceuticals, Inc.
                                            157 Technology Drive
                                            Irvine, CA 92602
                                            Attention: Rajesh C. Shrotriya, M.D.
                                            Facsimile: (949) 788-6706

16.4  GOVERNING LAW, JURISDICTION

      This Agreement shall be governed by, and interpreted in accordance with
      the laws of Switzerland, without reference to conflicts of laws
      principles. The United Nations Conventions on Contracts for the
      International Sale of Goods shall not be applicable to this Agreement. The
      validity of the intellectual property rights shall be subject to an
      evaluation under the law of the country in which the intellectual property
      rights were applied for or have been issued. Exclusive jurisdiction shall
      vest with the Geneva courts.

16.5  SEVERABILITY

      If any provision of this Agreement is determined by any court or
      administrative tribunal of competent jurisdiction to be invalid or
      unenforceable, the Parties shall negotiate in good faith a replacement
      provision that is commercially equivalent, to the maximum extent permitted
      by applicable law, to such invalid or unenforceable provision. The
      invalidity or unenforceability of any provision of this Agreement shall
      not affect the validity or enforceability of the other provisions of this
      Agreement.

16.6  ENTIRE AGREEMENT AND AMENDMENTS

      This Agreement, together with all Exhibits attached hereto, constitutes
      the entire agreement between the Parties, and supersedes all prior
      agreements, understandings and communications between the Parties, with
      respect to the subject matter hereof. No modification or amendment of this
      Agreement shall be binding upon the Parties unless in writing and executed
      by the duly authorized representative of each of the Parties; this shall
      also apply to any change of this clause.

16.7  WAIVERS

      The failure by either Party hereto to assert any of its rights hereunder,
      including, but not limited to, the right to terminate this Agreement due
      to a breach or default by the other Party hereto, shall not be deemed to
      constitute a waiver by that Party of its right thereafter to enforce each
      and every provision of this Agreement in accordance with its terms.

                                                                              31
<PAGE>

17.   PUBLIC ANNOUNCEMENTS

17.1  Except as required by law (including, without limitation, the applicable
      disclosure requirements of any relevant regulatory authority or stock
      exchange) and as permitted by Section 12.3, neither Party shall make any
      public announcement concerning this Agreement, any Contract Product or any
      other subject matter hereof without the prior written consent of the other
      Party, which shall not be unreasonably withheld or delayed. It shall not
      be unreasonable for a Party to withhold consent with respect to any public
      announcement containing any of such Party's Confidential Information. In
      the event of any required or proposed public announcement, (i) the Parties
      shall consult with each other in good faith as to the timing thereof, and
      (ii) the Party making such announcement shall provide the other Party with
      a copy of the proposed text prior to such announcement sufficiently in
      advance of the scheduled release of such announcement to afford such other
      Party a reasonable opportunity to review and comment upon the proposed
      text. Notwithstanding the foregoing, the Parties agree to prepare a
      mutually agreeable press release that may be used by either Party in
      connection with this Agreement, and any further announcement containing
      substantially the same information may be used without the need to seek
      the consent of the other Party. In the case of unintentional public
      disclosure concerning this Agreement, any Contract Product or any other
      subject matter hereof, the disclosing Party shall promptly inform the
      other Party of such disclosure and the other Party shall be entitled to
      make a public announcement regarding the subject matter of the disclosure.
      The other Party shall notify the disclosing Party of their intention to
      make such an announcement.

17.2  Following a Party's consent to or approval of the public announcement of
      any information pursuant to this Section 17, both Parties shall be
      entitled to make subsequent public announcements of such information
      without renewed compliance with this Section 17, unless the scope and/or
      duration of such consent or approval is expressly limited.

17.3  Upon conclusion of this Agreement, the Parties will publish a press
      release on their future cooperation.

EXHIBITS:

Exhibit 1.6                Description of D-63153
Exhibit 1.28               Zentaris' Know-How
Exhibit 1.29               Zentaris' Patent Rights
Exhibit 8.1                Specifications for Clinical Supplies

                            [SIGNATURE PAGE FOLLOWS]

                                                                              32
<PAGE>

IN WITNESS WHEREOF, the Parties have caused this Agreement to be executed this
12th day of August 2004, by their duly authorized representatives.

Zentaris                                 Spectrum

By: /S/ JURGEN ENGEL                     By: /S/ RAJESH C. SHROTRIYA
    -------------------------                ----------------------------------
    Name: Prof. Dr. Jurgen Engel             Name: Rajesh C. Shrotriya, M.D.
    Title: Chairman and                      Title: Chairman, CEO and President
           Managing Director

                                                                              33
<PAGE>

EXHIBIT 1.6

[Intentionally Redacted]

D-63153

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Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions.

                                                                              34
<PAGE>
EXHIBIT 1.28

[Intentionally Redacted]

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Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions.

                                                                              35
<PAGE>

EXHIBIT 1.29

[Intentionally Redacted]

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Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions.

                                                                              36

<PAGE>

EXHIBIT 8.1

[Intentionally Redacted]

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Securities and Exchange Commission. Confidential treatment has been requested
with respect to the omitted portions.

                                                                              371ST AMENDMENT OT REVOLVING LOAN AGREEMENT

 

Exhibit 10.1

FIRST AMENDMENT TO REVOLVING LOAN AGREEMENT

     THIS FIRST AMENDMENT TO REVOLVING LOAN AGREEMENT (the “First Amendment”) dated as of the 11th
day of January, 2005, is entered into by and between SEACOAST BANKING CORPORATION OF FLORIDA, a
Florida corporation, with its principal office and place of business located at 815 Colorado
Avenue, Stuart, Florida 34994 (the “Borrower”) and SUNTRUST BANK, a Georgia corporation, 200 S.
Orange Avenue, Orlando, Florida 33801 (the “Bank”).

W I T N E S S E T H:

     WHEREAS, the Borrower and the Bank previously entered into that certain Revolving Loan
Agreement dated as of September 6, 2001 (the “Loan Agreement”), pursuant to which the Bank agreed,
among other things, to extend to the Borrower a revolving line of credit loan in the maximum
principal amount of $5,000,000.00 (the “Loan”) for the purposes set forth in the Loan Agreement;
and

     WHEREAS, the Borrower has requested the Bank to increase the amount available for borrowing
under the Loan by $10,000,000.00 to $15,000,000.00 and to otherwise modify the Loan Agreement and
the Bank has agreed to do so subject to the additional conditions, limitations and requirements as
hereinafter set forth in this First Amendment.

     NOW, THEREFORE, for and in consideration of the mutual premises contained herein and for other
good and valuable consideration, the receipt and sufficiency whereof is hereby acknowledged, the
parties hereto do hereby agree as follows:

     1. Amendments to Loan Agreement. The Loan Agreement is hereby amended as follows:

                    (a) The definitions of the terms “Maturity Date” and “Permitted Loan Limit”
contained in Section 1 of the Loan Agreement are hereby deleted in their entirety and the following
are substituted in lieu thereof:

     “Maturity Date” shall mean September 6, 2005.

     “Permitted Loan Limit” shall mean $15,000,000.00.

     2. Reaffirmation of Negative Pledge. The Borrower hereby specifically reaffirms the
Negative Pledge and acknowledges and agrees that it is valid, in full force and effect and
enforceable in accordance with its terms, without any claims, counterclaims, defenses or other
rights of offset whatsoever and the Borrower will not, at any time during the term of the Loan,
sell any of the stock of FNBT.

     3. Representations and Warranties. The Borrower hereby reaffirms all of the
representations and warranties contained in the Loan Agreement as though made and given in
connection with the execution and delivery of this First Amendment and further certifies that all
such representations and warranties are true and correct on and as of the date hereof.

     4. Ratification. Except for any modification of and/or amendment to the Loan Agreement
as herein provided, no other term, condition or provision of the Loan Agreement shall be considered
to be altered or amended, and this First Amendment shall not be considered a novation. The
Borrower agrees that the amounts extended by the Bank to the Borrower hereunder are absolutely and
unconditionally due and owing to the Bank, and are not subject to any claims, counterclaims,
defenses or other rights of offset whatsoever.

 

 

     5. Complete Agreement. This First Amendment constitutes the complete agreement between
the parties hereto and incorporates all prior discussions, agreements and representations made in
regard to the matters set forth herein.

     6. Capitalized Terms. Capitalized terms used in this First Amendment shall have the
meanings assigned to them in the Loan Agreement unless the context hereof clearly dictates
otherwise.

[Signature on Following Page]

2

 

     IN WITNESS WHEREOF, the Bank and the Borrower have caused this First Amendment to be executed
by their respective duly authorized officers as of the date first above written.

	 	 	 	 	 
	 	BORROWER:

SEACOAST BANKING CORPORATION OF FLORIDA

 	 
	 	By:  	/s/ William R. Hahl
 	 
	 	 	William R. Hahl	 
	 	 	Executive Vice President and Chief
Financial
Officer 	 
	 

	 	 	 	 	 
	 	BANK:

SUNTRUST BANK

 	 
	 	By:  	/s/ William Christensen
 	 
	 	 	William Christensen	 
	 	 	Vice President 	 
	 

3

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