Document:

Seventh Amendment

 Exhibit 10.270 
 SEVENTH LEASE AMENDMENT TO LEASE AGREEMENT 
 THIS
SEVENTH LEASE AMENDMENT TO LEASE AGREEMENT (hereinafter referred to as the “Amendment”) is made as of the 1st day of September 2009, by and between DUKE REALTY LIMITED PARTNERSHIP, an Indiana limited partnership
doing business in North Carolina as Duke Realty of Indiana Limited Partnership (hereinafter referred to as “Landlord”) and PPD DEVELOPMENT LP, a Texas limited partnership and successor in interest to PPD Development, Inc.
(hereinafter referred to as “Tenant”). 
 WITNESSETH: 
 WHEREAS, pursuant to a Lease Agreement dated January 28, 1998 by and between Landlord and Tenant, and as amended by that certain First
Amendment to Lease Agreement dated July 9, 1997, and as amended by that certain Second Amendment to Lease Agreement dated June 26, 1998, and as amended by that certain First Amendment to Lease Agreement dated February 18, 1999, and as
amended by that certain Fourth Amendment to Lease Agreement July 6, 1999, and as amended by that certain Fifth Amendment to Lease Agreement dated October 1, 2002, and as further amended by that certain Sixth Amendment to Lease Agreement
dated February 6, 2006 (collectively the Lease Agreement, and all amendments thereto shall be referred to herein collectively as the “Lease”), Landlord leases to Tenant certain premises containing approximately 100,987 rentable square
feet in a building (the “Building”) located on certain land (the “Land”) at 3900 North Paramount Parkway, Morrisville, Wake County, North Carolina, 27560 (the “Premises”), within Perimeter Park (the “Park”),
all as more particularly described in the Lease; 
 WHEREAS, Landlord and Tenant desire to restructure and extend the Lease
Term; and 
 WHEREAS, Landlord and Tenant desire to amend certain provisions of the Lease to reflect such extension. 

NOW, THEREFORE, for and in consideration of Ten Dollars ($10.00) paid by Landlord and Tenant to one another, and for other good and
valuable consideration, the receipt and sufficiency of which are hereby acknowledged by Landlord and Tenant, Landlord and Tenant amend the Agreement as follows: 
 1. Incorporation of Recitals. The above recitals are hereby incorporated into this Amendment as if fully set forth herein. All capitalized terms used herein but undefined shall have the meaning as
defined in the Lease. 
 2. Term. Section 1(b) of the Lease is amended so that the term “Termination
Date” shall mean and refer to November 30, 2023. 
 3. Base Rent, Operating Expenses and Security Deposit.
Effective as of January 1, 2010 (the “Effective Date”), Article 2 of the Lease is hereby deleted and replaced with the following: 
 “2. RENT. 
 (a) Annual Base Rent: 

			
	 01/01/2010 – 12/31/2010
	  	$1,979,345.00
	 01/01/2011 – 12/31/2011
	  	$2,018,932.08
	 01/01/2012 – 12/31/2012
	  	$2,059,310.76
	 01/01/2013 – 12/31/2013
	  	$2,100,497.04
	 01/01/2014 – 12/31/2014
	  	$2,142,507.00
	 01/01/2015 – 12/31/2015
	  	$2,185,357.08
	 01/01/2016 – 12/31/2016
	  	$2,229,064.20
	 01/01/2017 – 12/31/2017
	  	$2,273,645.52
	 01/01/2018 – 12/31/2018
	  	$2,319,118.44
	 01/01/2019 – 12/31/2019
	  	$2,365,500.96
	 01/01/2020 – 12/31/2020
	  	$2,412,810.84
	 01/01/2021 – 12/31/2021
	  	$2,461,067.16
	 01/01/2022 – 12/31/2022
	  	$2,510,288.52
	 01/01/2023 – 11/30/2023
	  	$2,347,119.72 (11 months)
	
	Monthly Installments of Base Rent:
		
	 01/01/2010 – 12/31/2010
	  	$164,945.43
	 01/01/2011 – 12/31/2011
	  	$168,244.34
	 01/01/2012 – 12/31/2012
	  	$171,609.23
	 01/01/2013 – 12/31/2013
	  	$175,041.42
	 01/01/2014 – 12/31/2014
	  	$178,542.25
	 01/01/2015 – 12/31/2015
	  	$182,113.09
	 01/01/2016 – 12/31/2016
	  	$185,755.35
	 01/01/2017 – 12/31/2017
	  	$189,470.46
	 01/01/2018 – 12/31/2018
	  	$193,259.87
	 01/01/2019 – 12/31/2019
	  	$197,125.08
	 01/01/2020 – 12/31/2020
	  	$201,067.57
	 01/01/2021 – 12/31/2021
	  	$205,088.93
	 01/01/2022 – 12/31/2022
	  	$209,190.71
	 01/01/2023 – 11/30/2023
	  	$213,374.52

 Tenant shall pay to Landlord the Annual Base Rent in the monthly installments of Base
Rent in advance, without demand, deduction or offset, on the Effective Date and on or before the first day of each and every calendar month thereafter during the Lease Term. The monthly installments of Base Rent for partial calendar months shall be
prorated. 
 (b) Annual Rental Adjustment Definitions. 
 (i) “Annual Rental Adjustment” shall mean the amount of Tenant’s Proportionate Share of Operating Expenses for a
particular calendar year. 
 (ii) “Operating Expenses” shall mean the amount of all of Landlord’s costs
and expenses paid or incurred in operating, repairing, replacing and maintaining the Building and the common areas in good condition and repair for a particular calendar year (including all additional costs and expenses that Landlord reasonably
determines that it would have paid or incurred during such year if the Building had been fully occupied), including by way of illustration and not limitation, the following: all Real Estate Taxes (as hereinafter defined), insurance premiums and
deductibles; water, sewer, electrical and other base Building utility charges other than Tenant’s critical cooling systems, UPS systems or any similar system and the separately billed electrical and other charges paid by Tenant as provided in
this Lease (or

 
other tenants in the Building); service and other charges incurred in the repair, replacement, operation and maintenance of the elevators and the heating, ventilation and air-conditioning system;
costs associated with providing fitness facilities, if any; cleaning and other janitorial services; tools and supplies; repair costs; landscape maintenance costs; security patrols; license, permit and inspection fees; management fees; administrative
fees; supplies, costs, wages and related employee benefits payable for the management, maintenance and operation of the Building; maintenance, repair and replacement of the driveways, parking and sidewalk areas (including snow and ice removal),
landscaped areas, and lighting; and maintenance and repair costs, dues, fees and assessments incurred under any covenants or charged by any owners association. The cost of any Operating Expenses that are capital in nature shall be amortized over the
useful life of the improvement (as reasonably determined by Landlord), and only the amortized portion shall be included in Operating Expenses. Notwithstanding anything to the contrary in this Lease, the management fees for any single year shall not
exceed 4% of the annual gross rental receipts for the Building for that year. 
 (iii) “Tenant’s Proportionate
Share” shall be calculated by dividing the rentable square footage of the Premises by the rentable square footage of the Building. Tenant’s Proportionate Share equals one hundred percent (100%). Tenant’s Proportionate Share shall
also be known as Tenant’s pro rata share. 
 (iv) “Tenant’s Proportionate Share of Operating
Expenses” shall mean an amount equal to the remainder of (i) the product of Tenant’s Proportionate Share times the Operating Expenses less (ii) Tenant’s Proportionate Share times the Operating Expenses for the Base Year
which is 2010, provided that such amount shall not be less than zero. 
 (v) “Real Estate Taxes” shall mean any
form of real estate tax or assessment or service payments in lieu thereof, and any license fee, commercial rental tax or similar franchise tax, improvement bond or other similar charge or tax (other than inheritance, personal income or estate taxes)
imposed upon the Building or common areas, or against Landlord’s business of leasing the Building, by any authority having the power to so charge or tax, together with costs and expenses of contesting the validity or amount of the Real Estate
Taxes. 
 (c) Payment of Additional Rent. 
 (i) Any amount required to be paid by Tenant hereunder (in addition to Annual Base Rent) and any charges or expenses incurred by Landlord on behalf of Tenant under the terms of this Lease shall be
considered “Additional Rent” payable in the same manner and upon the same terms and conditions as the Annual Base Rent reserved hereunder, except as set forth herein to the contrary. Any failure on the part of Tenant to pay such Additional
Rent when and as the same shall become due shall entitle Landlord to the remedies available to it for non-payment of Annual Base Rent. 
 (ii) In addition to the Annual Base Rent specified in this Lease, commencing on the Effective Date, Tenant shall pay to Landlord as Additional Rent for the Premises, in each calendar year or partial
calendar year during the Lease Term, an amount equal to the Annual Rental Adjustment for such calendar year. Landlord shall estimate the Annual Rental Adjustment annually, and written notice thereof shall be given to Tenant prior to the beginning of
each calendar year. Tenant shall pay to Landlord each month, at the same time the monthly installment of Base Rent is due, an amount equal to one-twelfth ( 1/12) of the estimated Annual Rental Adjustment. If Operating
Expenses increase during a calendar year, Landlord may increase the estimated Annual Rental Adjustment during such year by giving Tenant written notice to that effect, and thereafter Tenant shall pay to Landlord, in each of the remaining months of
such year, an amount equal to the amount of such increase in the estimated Annual 

 
Rental Adjustment divided by the number of months remaining in such year. Within a reasonable time after the end of each calendar year, Landlord shall prepare and deliver to Tenant a statement
showing the actual Annual Rental Adjustment. Within thirty (30) days after receipt of the aforementioned statement, Tenant shall pay to Landlord, or Landlord shall credit against the next rent payment or payments due from Tenant, as the case
may be, the difference between the actual Annual Rental Adjustment for the preceding calendar year and the estimated amount paid by Tenant during such year. This Section (ii) shall survive the expiration or any earlier termination of
this Lease. 
 (d) In the event Tenant shall dispute the amount set forth in any statement provided by Landlord pursuant to
Section (ii) above, Tenant shall have the right, not later than thirty (30) days following the receipt of such statement and upon condition that Tenant shall first deposit with Landlord the undisputed portion, if any, to elect to
have Landlord’s books and records with respect to such calendar year to be audited by auditors selected by Tenant and subject to Landlord’s reasonable approval or to notify Landlord of a disputed item which Tenant does not believe requires
an audit to be resolved. If such dispute shall not have been settled by agreement within thirty (30) days after Tenant provides Landlord with such written notice, Tenant may elect to conduct an audit of such item in accordance with this
paragraph. All such audits must be completed no later than one hundred twenty (120) days after receipt of such statement, with such time limit to be extended due to delays caused by Landlord. All costs for the audit shall be borne by Tenant
unless the audit discloses an overcharge of ten percent (10%) or more, in which case the costs of the audit not to exceed $5,000 shall be borne by Landlord. If Tenant shall not request an audit in accordance with the provisions of this
paragraph within the time periods specified above, such statement shall be final and binding for all purposes hereof. 
 (e)
Utilities for the Premises included as a part of Operating Expenses shall not include utility charges and HVAC beyond the hours of 8:00 AM to 6:00 PM, Monday-Friday, and 8:00 AM to 1:00 PM on Saturday. Any usage by Tenant of HVAC and utilities at
times other than the aforesaid hours shall be at the sole cost and expense of Tenant. Landlord shall bill Tenant directly for all such costs as a separate item of Additional Rent, and Tenant shall pay such amounts within fifteen (15) days of
receipt of demand for payment from Landlord, and the failure by Tenant to pay such costs in accordance with the demand made by Landlord shall be treated in the same manner under this Lease as a non-payment of base rent by Tenant with Landlord being
afforded the same rights and remedies for such non-payment. 
 Landlord shall calculate and incur Operating Expenses in a manner
that is substantially consistent with previous years of the Lease Term. Notwithstanding anything in the Lease to the contrary, but subject to the cap in management fees in Section 2(b)(ii), with the exception of “Uncontrollable
Expenses” (defined as Real Estate Taxes, insurance premiums, utilities, janitorial services, snow removal, landscaping, management fees, and charges assessed against the Building pursuant to any covenants or owner’s association). Increases
in all other Operating Expenses that are not Uncontrollable Expenses (herein “Controllable Expenses”) shall be limited to an eight percent (8%) per annum increase over the amount of the Controllable Expenses for the immediately
preceding calendar year. Landlord shall use commercially reasonable efforts to manage the Operating Expenses.” 
 (f)
Tenant may make any payment due to Landlord under this Lease by check, wire or via the Automated Clearing House (“ACH”) network. Landlord shall provide wiring instructions and/or ACH payment information upon request by Tenant. 

4. Tenant Allowance. Provided that no uncured material nonmonetary default and no uncured monetary default by Tenant (of which
Tenant has received notice and failed to cure prior to the expiration of the applicable cure period) has occurred and is then continuing Landlord shall provide an

 
allowance payable in cash to Tenant in three installments, which shall be due and payable on the following dates: $989,672.58 on March 31, 2010, $706,909.00 on June 30, 2013, and
$706,909.00 on June 30, 2018 (the “Extension Allowance”). The Extension Allowance shall, at the option of Tenant, be payable by check deliverable to the address for notices set forth in Article 20, or by wire pursuant to wiring
instructions provided by Tenant. Notwithstanding anything to the contrary in the Lease or this Amendment, Tenant, in its sole discretion, may use the Extension Allowance in any manner and for any purpose (whether or not related to the Premises or
this Lease) Tenant deems appropriate, including, but not limited to, using the Extension Allowance in connection with various alterations to the Premises or using the Extension Allowance to pay Tenant’s rent. Tenant acknowledges and agrees,
that in the event Tenant, in its sole discretion, elects to use the Extension Allowance for the construction and installation of any alterations to the Premises, such alterations shall be subject to and performed in accordance with Article 5
of the Lease. Tenant shall not be required to provide any accounting of Tenant’s use of the Extension Allowance to Landlord. 
 5. Option to Renew. Section 1(c) of the Lease is hereby deleted in its entirety and replaced with the following: 
 “(c). Options to Extend. 
 (a) Grant and Exercise of Option. Provided
that no uncured material default by Tenant has occurred and is then continuing, Tenant shall have the option to extend the Lease Term for two (2) additional periods of five (5) years each (the “Extension Term(s)”). Each Extension
Term shall be upon the same terms and conditions contained in the Lease except (x) this provision giving two (2) extension options shall be amended to reflect the remaining options to extend, if any, and (y) any improvement allowances
or other concessions applicable to the Premises under the Lease shall not apply to the Extension Term, and (z) the Base Annual Rent shall be adjusted as set forth below (the “Rent Adjustment”). Tenant shall exercise each option by
delivering to Landlord, no later than six (6) months prior to the expiration of the preceding term, written notice of Tenant’s desire to extend the Lease Term. Tenant’s failure to timely exercise such option shall be deemed a waiver
of such option and any succeeding option. Landlord shall notify Tenant of the amount of the Rent Adjustment no later than ninety (90) days prior to the commencement of the Extension Term. Tenant shall be deemed to have accepted the Rent
Adjustment if it fails to deliver to Landlord a written objection thereto within fifteen (15) days after receipt thereof. If Tenant properly exercises its option to extend, Landlord and Tenant shall execute an amendment to the Lease (or, at
Landlord’s option, a new lease on the form then in use for the Building) reflecting the terms and conditions of the Extension Term within thirty (30) days after Tenant’s acceptance (or deemed acceptance) of the Rent Adjustment.

 (b) Rent Adjustment. The Base Annual Rent for the applicable Extension Term shall be an amount
equal to ninety-five percent (95%) of the Base Annual Rent then being received by Landlord from current tenants of the Building for space of comparable size and quality and with similar or equivalent improvements as are found in the Building,
and if none, then in similar buildings in the Park; provided, however, that in no event shall the Base Annual Rent during the applicable Extension Term be less than the highest Base Annual Rent payable during the immediately preceding term. The
monthly installments of Base Rent shall be an amount equal to one-twelfth ( 1/12) of the Base Annual Rent for the applicable Extension Term and shall be paid at the same time and in the same manner as provided in the Lease.” 
 6. Notices. Article 20 of the Lease is hereby amended as follows: With respect to Landlord and Tenant, the addresses for
notices are: 

			
	Landlord:	  	Duke Realty Limited Partnership
		  	 c/o Duke Realty Corporation

		  	 Attn.: Raleigh Market – Vice President,

		  	 Asset Management & Customer Service 

		  	 3005 Carrington Mill Road, Suite 100 

		  	 Morrisville, North Carolina, 27560 

		
	With a copy to:	  	Duke Realty Limited Partnership
		  	c/o Duke Realty Corporation
		  	Attn: Raleigh Market Attorney
		  	3950 Shackleford Road, Suite 300
		  	 Duluth, Georgia 30096-8268

		
	With Payments to:	  	Duke Realty Limited Partnership
		  	 75 Remittance Drive, Suite 3205

		  	 Chicago, IL 60675-3205

		
	Tenant:	  	PPD Development, LP
		  	929 North Front Street
		  	Wilmington, NC 28401
		  	Attn: Corporate Site Services Administrator
		
	With a copy to:	  	PPD Development, LP
		  	929 North Front Street
		  	Wilmington, NC 28401
		  	Attn: General Counsel

 7. Brokers. Article 21 of the Lease is hereby deleted and replaced with
the following: 
 “21. BROKER’S CLAUSE. Except for UGL EQUIS CORPORATION, an Illinois corporation, representing
Tenant, whose commission shall be paid by Landlord, Landlord and Tenant each represents and warrants to the other that neither party has engaged or had any conversations or negotiations with any broker, finder or other third party concerning the
matters set forth in this Amendment who would be entitled to any commission or fee based on the execution of this Amendment. Landlord and Tenant each hereby indemnifies the other against and from any claims for any brokerage commissions and all
costs, expenses and liabilities in connection therewith, including, without limitation, reasonable attorneys’ fees and expenses actually incurred, for any breach of the foregoing. The foregoing indemnification shall survive the termination of
the Lease for any reason.” 
 8. Covenant of Tenant. Article 26 of the Lease is hereby amended by adding the
following provision to the end of the last sentence: “Notwithstanding anything to the contrary herein, in no event will Tenant be required to make any changes to the provisions in this Amendment regarding the Extension Allowance or any remedies
Tenant may have in the event of a failure to comply with such obligations.” 
 9. Landlord Transfer.
Section 27(g) of the Lease is hereby amended by adding the following provision: “As a condition of the release in this Section 27(g), Landlord and any such new owner shall

 
enter into a written agreement acknowledging the new owner’s obligations and liabilities of Landlord under this Lease that shall specifically include a statement that the new owner will
comply with Landlord’s obligation to make the Extension Allowance payments as provided Section 4 of this Amendment.” 
 10. Tenant Remedies. Section 27(l) of the Lease is hereby amended by adding the following provision: “(iv) Notwithstanding anything to the contrary in the Lease, in addition to any other remedies which may be
available, in the event Landlord fails to make all or any portion of an installment payment of the Extension Allowance on the date specified in this Lease, Tenant may, in its sole discretion, after giving Landlord written notice of such failure to
make a payment and thirty (30) days to make the payment, credit the amount of the installment payment of the Extension Allowance that Landlord has failed to make against any Annual Base Rent or Additional Rent that may be payable under the
Lease.” 
 11. Miscellaneous. Section 27(m) of the Lease is hereby amended by adding the following
provision: “Notwithstanding anything to the contrary, Tenant shall be permitted to deduct any amount of the Extension Allowance that Landlord has failed to make against any rent payment due under the Lease, including, but not limited to base
rent or Additional Rent, regardless of whether any holder of a mortgage or beneficiary of a deed of trust, or any assignee thereof, takes over Landlord’s rights under this Lease.” 
 12. Emergency Generator. 
 (a) Tenant, at its sole cost and expense and subject to the terms of the Lease, shall have the right to operate and maintain the emergency generator and related equipment (collectively, the
“Generator”) currently serving the Premises. Tenant shall operate and maintain the Generator in accordance with all federal, state and local laws and regulations and with any protective covenants. Tenant shall be solely responsible for
obtaining any necessary permits and licenses required to operate and maintain the Generator and shall provide copies thereof to Landlord. Tenant, at Tenant’s sole cost and expense, shall maintain existing screening around the Generator. Tenant
shall at all times keep the Generator and the surrounding area in a clean and orderly condition. 
 (b) Tenant, at its sole cost
and expense, shall be responsible for removing the Generator and any screening surrounding the Generator and for restoring the Building and/or common areas affected by the Generator and screening to their original condition after such removal.
Tenant agrees, within thirty (30) days after written notice from Landlord, to remove the Generator and any screening surrounding same in the event any governmental entity or applicable law or regulation requires removal thereof or Tenant fails
to materially comply with the terms stated herein within thirty (30) days after such notice. Such removal shall be in accordance with all of the terms and conditions set forth herein. If Tenant fails to remove the Generator and screening
surrounding same from the Building or Common Areas upon expiration or earlier termination of the Lease, or after expiration of the thirty (30) day notice period provided above, the Generator and any screening surrounding same shall be deemed
abandoned by Tenant and shall become the property of Landlord, or Landlord may remove the same at Tenant’s expense. 
 13.
Severability. In the event any term, covenant or condition of this Amendment, the Lease, or any amendments thereto shall to any extent be invalid or unenforceable, the remainder shall not be affected thereby and each term, covenant or
condition shall be valid and enforceable to the full extent permitted by law. 
 14. Successors and Assigns. This
Amendment shall apply to, inure to the benefit of, and be binding upon the parties hereto and upon their respective heirs, legal representatives, successors and permitted assigns, except as otherwise provided herein. 

 15. Authority of Tenant. Tenant certifies to Landlord that it is authorized to enter
into this Amendment, and that those persons signing below on its behalf are authorized to do so, and shall promptly upon the request of Landlord provide a resolution to this effect. 
 16. Interpretation. Although the printed provisions of this Amendment were drafted by Landlord, such fact shall not cause this
Amendment to be construed either for or against Landlord or Tenant. All capitalized terms, not otherwise defined, shall be defined as provided in the Lease. 
 17. Full Force and Effect. Except as modified hereby, the Lease remains unmodified and in full force and effect. 
 18. Governing Law. This Amendment shall be governed by and construed in accordance with the laws of the State of North Carolina. 
 19. Mutual Acknowledgment of Non-Existence of Claims. Landlord and Tenant acknowledge and agree that as of the day hereof there are
no known claims by either party against the other party hereto arising from the relationship as Landlord and Tenant, respectively, pursuant to the Lease, as amended. 
 20. Confidentiality. Except as otherwise required by law to be disclosed by Tenant, the terms and provisions of the Lease and this Amendment are strictly confidential, are to be shared by Tenant
only with its accountant, employees, and attorneys, and each of those parties shall be advised of the confidential nature of the lease and this Amendment. 
 21. Memorandum of Lease. The parties agree that this Lease may not be recorded but that either party may request that the other execute a Memorandum of Lease which may be recorded. The parties
agree to remove the Memorandum of Lease of record upon the expiration or earlier termination of this Lease. In the event of an early termination as a result of Tenant’s default and vacation of the Premises, Tenant agrees that Landlord can
unilaterally remove the Memorandum of Lease of record. 
 [Execution signatures contained on the following page]

 IN WITNESS WHEREOF, the undersigned have caused this Amendment to be executed under seal and
delivered as of the day and year first above written. 
  

													
		 		 		 		 	LANDLORD:
					
		 		 		 		 	DUKE REALTY LIMITED PARTNERSHIP, an Indiana limited partnership doing business in North Carolina as Duke Realty of Indiana Limited Partnership
						
		 		 		 		 	 By:
	 	Duke Realty Corporation, an Indiana corporation, its General Partner
							
		 		 		 		 		 	By:	 	 /s/ Jeffrey B. Sheehan

		 		 		 		 		 	Name:	 	 Jeffrey B. Sheehan

		 		 		 		 		 	Title:	 	 Senior VP

				
	ATTEST:	 		 		 	 TENANT:

					
		 	By:	 	 /s/ Charles H. Munn
	 		 	 PPD DEVELOPMENT LP, a Texas limited partnership

		 	Name:	 	 Charles H. Munn
	 		 		 		 	
		 	Title:	 	 Assistant General Counsel
	 		 		 		 	
		 		 		 		 	By:	 	 PPD GP, LLC, a Delaware limited liability company, its General Partner

							
		 		 		 		 		 	By:	 	 /s/ William J. Sharbaugh

		 		 		 		 		 	Name:	 	 William J. Sharbaugh

		 		 		 		 		 	Title:	 	 Chief Operating Officer

  

 Guarantor hereby executes this Amendment to evidence its consent to this Amendment. 
  

											
		 		 		 		 	GUARANTOR:
					
	ATTEST:	 		 		 		 	PHARMACEUTICAL PRODUCT DEVELOPMENT, INC., a North Carolina Corporation
		 	 By:
	 	 /s/ Charles H. Munn
	 		 		 	
		 	 Name:
	 	 Charles H. Munn
	 		 		 	
		 	 Title:
	 	 Assistant General Counsel
	 		 		 	
		 		 		 		 	By:	 	 /s/ William J. Sharbaugh

		 		 		 		 	Name:	 	 William J. Sharbaugh

		 		 		 		 	Title:	 	 Chief Operating Officer

 END OF EXECUTION SIGNATURESNinth Amendment

 Exhibit 10.271 
 NINTH LEASE AMENDMENT TO LEASE AGREEMENT 
 THIS NINTH
LEASE AMENDMENT TO LEASE AGREEMENT (hereinafter referred to as the “Amendment”) is made as of the 1st day of September 2009, by and between DUKE REALTY LIMITED PARTNERSHIP, an Indiana limited partnership doing
business in North Carolina as Duke Realty of Indiana Limited Partnership, successor by merger to Weeks Realty, L.P. (hereinafter referred to as “Landlord”) and PPD DEVELOPMENT LP, a Texas limited partnership and successor in
interest to PPD Development, Inc. (hereinafter referred to as “Tenant”). 
 WITNESSETH: 
 WHEREAS, pursuant to a Lease Agreement dated June 26, 1998 by and between Landlord and Tenant, as amended by that certain First
Amendment to Lease Agreement dated October 28, 1998, and as amended by that certain Second Lease Amendment to Lease Agreement dated October 1, 2002, and as amended by that certain Third Lease Amendment to Lease Agreement dated
September 22, 2003, and as amended by that certain Fourth Lease Amendment to Lease Agreement dated March 31, 2005, and as amended by that certain Fifth Lease Amendment to Lease Agreement dated July 7, 2005, and as amended by that
certain Sixth Lease Amendment to Lease Agreement dated December 30, 2005, and as amended by that certain Seventh Lease Amendment to Lease Agreement dated February 6, 2006, and as amended by that certain Eighth Lease Amendment to Lease
Agreement dated September 24, 2007 (the Lease Agreement, and all amendments thereto shall be referred to herein collectively as the “Lease”), Landlord leased to Tenant certain premises consisting of approximately 105,572 rentable
square feet (the “Premises”) in a building (the “Building”) located on certain land (the “Land”) which had been provided the address of 4023 Paramount Parkway, but is now known as 3900 South Paramount Parkway,
Morrisville, Wake County, North Carolina 27560, within Perimeter Park (the “Park”) all as more particularly described in the Lease; 
 WHEREAS, Landlord and Tenant desire to restructure and extend the Lease Term; and 
 WHEREAS, Landlord and Tenant desire to amend certain provisions of the Lease to reflect such extension. 
 NOW,
THEREFORE, in consideration of the foregoing premises, the mutual covenants herein contained and each act performed hereunder by the parties, Landlord and Tenant hereby enter into this Amendment. 
 1. Incorporation of Recitals and Definitions. The above recitals are hereby incorporated into this Amendment as if fully set forth
herein. All capitalized terms used herein but undefined shall have the meaning as defined in the Lease. 
 2. Term.
Section 1(b) of the Lease is amended so that the term “Termination Date” shall mean and refer to November 30, 2023. 
 3. Base Rent, Operating Expenses and Security Deposit. Effective as of January 1, 2010 (the “Effective Date”), Article 2 of the Lease is hereby deleted and replaced with the
following: 
 “2. RENT. 
 (a) Annual Base Rent: 

			
	 01/01/2010 – 12/31/2010
	  	$2,069,211.24
	 01/01/2011 – 12/31/2011
	  	$2,110,595.40
	 01/01/2012 – 12/31/2012
	  	$2,152,807.32
	 01/01/2013 – 12/31/2013
	  	$2,195,863.56
	 01/01/2014 – 12/31/2014
	  	$2,239,780.80
	 01/01/2015 – 12/31/2015
	  	$2,284,576.44
	 01/01/2016 – 12/31/2016
	  	$2,330,268.00
	 01/01/2017 – 12/31/2017
	  	$2,376,873.36
	 01/01/2018 – 12/31/2018
	  	$2,424,410.88
	 01/01/2019 – 12/31/2019
	  	$2,472,899.16
	 01/01/2020 – 12/31/2020
	  	$2,522,357.04
	 01/01/2021 – 12/31/2021
	  	$2,572,804.20
	 01/01/2022 – 12/31/2022
	  	$2,624,260.32
	 01/01/2023 – 11/30/2023
	  	$2,453,683.43 (11 months)
	
	Monthly Installments of Base Rent:
		
	 01/01/2010 – 12/31/2010
	  	$172,434.27
	 01/01/2011 – 12/31/2011
	  	$175,882.95
	 01/01/2012 – 12/31/2012
	  	$179,400.61
	 01/01/2013 – 12/31/2013
	  	$182,988.63
	 01/01/2014 – 12/31/2014
	  	$186,648.40
	 01/01/2015 – 12/31/2015
	  	$190,381.37
	 01/01/2016 – 12/31/2016
	  	$194,189.00
	 01/01/2017 – 12/31/2017
	  	$198,072.78
	 01/01/2018 – 12/31/2018
	  	$202,034.24
	 01/01/2019 – 12/31/2019
	  	$206,074.93
	 01/01/2020 – 12/31/2020
	  	$210,196.42
	 01/01/2021 – 12/31/2021
	  	$214,400.35
	 01/01/2022 – 12/31/2022
	  	$218,688.36
	 01/01/2023 – 11/30/2023
	  	$223,062.13

 Tenant shall pay to Landlord the Annual Base Rent in the monthly installments of Base
Rent in advance, without demand, deduction or offset, on the Effective Date and on or before the first day of each and every calendar month thereafter during the Lease Term. The monthly installments of Base Rent for partial calendar months shall be
prorated. 
 (b) Annual Rental Adjustment Definitions. 
 (i) “Annual Rental Adjustment” shall mean the amount of Tenant’s Proportionate Share of Operating Expenses for a
particular calendar year. 
 (ii) “Operating Expenses” shall mean the amount of all of Landlord’s costs
and expenses paid or incurred in operating, repairing, replacing and maintaining the Building and the common areas in good condition and repair for a particular calendar year (including all additional costs and expenses that Landlord reasonably
determines that it would have paid or incurred during such year if the Building had been fully occupied), including by way of illustration and not limitation, the following: all Real Estate Taxes (as hereinafter defined), insurance premiums and
deductibles; water, sewer, electrical and base Building utility charges other than Tenant’s critical cooling systems, UPS systems or any similar system and the separately billed electrical and other charges paid by Tenant as provided in this
Lease (or other

  

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tenants in the Building); service and other charges incurred in the repair, replacement, operation and maintenance of the elevators and the heating, ventilation and air-conditioning system; costs
associated with providing fitness facilities, if any; cleaning and other janitorial services; tools and supplies; repair costs; landscape maintenance costs; security patrols; license, permit and inspection fees; management fees; administrative fees;
supplies, costs, wages and related employee benefits payable for the management, maintenance and operation of the Building; maintenance, repair and replacement of the driveways, parking and sidewalk areas (including snow and ice removal), landscaped
areas, and lighting; and maintenance and repair costs, dues, fees and assessments incurred under any covenants or charged by any owners association. The cost of any Operating Expenses that are capital in nature shall be amortized over the useful
life of the improvement (as reasonably determined by Landlord), and only the amortized portion shall be included in Operating Expenses. Notwithstanding anything to the contrary in this Lease, the management fees for any single year shall not exceed
4% of the annual gross rental receipts for the Building for that year. 
 (iii) “Tenant’s Proportionate
Share” shall be calculated by dividing the rentable square footage of the Premises by the rentable square footage of the Building. Tenant’s Proportionate Share equals 88.59%. Tenant’s Proportionate Share shall also be known as
Tenant’s pro rata share. 
 (iv) “Tenant’s Proportionate Share of Operating Expenses” shall mean an
amount equal to the remainder of (i) the product of Tenant’s Proportionate Share times the Operating Expenses less (ii) Tenant’s Proportionate Share times the Operating Expenses for the Base Year which is 2010, provided that such
amount shall not be less than zero. 
 (v) “Real Estate Taxes” shall mean any form of real estate tax or
assessment or service payments in lieu thereof, and any license fee, commercial rental tax or similar franchise tax, improvement bond or other similar charge or tax (other than inheritance, personal income or estate taxes) imposed upon the Building
or common areas, or against Landlord’s business of leasing the Building, by any authority having the power to so charge or tax, together with costs and expenses of contesting the validity or amount of the Real Estate Taxes. 
 (c) Payment of Additional Rent. 
 (i) Any amount required to be paid by Tenant hereunder (in addition to Annual Base Rent) and any charges or expenses incurred by Landlord on behalf of Tenant under the terms of this Lease shall be
considered “Additional Rent” payable in the same manner and upon the same terms and conditions as the Annual Base Rent reserved hereunder, except as set forth herein to the contrary. Any failure on the part of Tenant to pay such Additional
Rent when and as the same shall become due shall entitle Landlord to the remedies available to it for non-payment of Annual Base Rent. 
 (ii) In addition to the Annual Base Rent specified in this Lease, commencing on the Effective Date, Tenant shall pay to Landlord as Additional Rent for the Premises, in each calendar year or partial
calendar year during the Lease Term, an amount equal to the Annual Rental Adjustment for such calendar year. Landlord shall estimate the Annual Rental Adjustment annually, and written notice thereof shall be given to Tenant prior to the beginning of
each calendar year. Tenant shall pay to Landlord each month, at the same time the monthly installment of Base Rent is due, an amount equal to one-twelfth ( 1/12) of the estimated Annual Rental Adjustment. If Operating
Expenses increase during a calendar year, Landlord may increase the estimated Annual Rental Adjustment during such year by giving Tenant written notice to that effect, and thereafter Tenant shall pay to Landlord, in each of the remaining months of
such year, an amount equal to the amount of such increase in the estimated Annual Rental Adjustment divided by the number of months remaining in such year. Within a reasonable time 

  

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after the end of each calendar year, Landlord shall prepare and deliver to Tenant a statement showing the actual Annual Rental Adjustment. Within thirty (30) days after receipt of the
aforementioned statement, Tenant shall pay to Landlord, or Landlord shall credit against the next rent payment or payments due from Tenant, as the case may be, the difference between the actual Annual Rental Adjustment for the preceding calendar
year and the estimated amount paid by Tenant during such year. This Section (ii) shall survive the expiration or any earlier termination of this Lease. 
 (d) In the event Tenant shall dispute the amount set forth in any statement provided by Landlord pursuant to Section (ii) above, Tenant shall have the right, not later than thirty
(30) days following the receipt of such statement and upon condition that Tenant shall first deposit with Landlord the undisputed portion, if any, to elect to have Landlord’s books and records with respect to such calendar year to be
audited by auditors selected by Tenant and subject to Landlord’s reasonable approval or to notify Landlord of a disputed item which Tenant does not believe requires an audit to be resolved. If such dispute shall not have been settled by
agreement within thirty (30) days after Tenant provides Landlord with such written notice, Tenant may elect to conduct an audit of such item in accordance with this paragraph. All such audits must be completed no later than one hundred twenty
(120) days after receipt of such statement, with such time limit to be extended due to delays caused by Landlord. All costs for the audit shall be borne by Tenant unless the audit discloses an overcharge of ten percent (10%) or more, in
which case the costs of the audit not to exceed $5,000 shall be borne by Landlord. If Tenant shall not request an audit in accordance with the provisions of this paragraph within the time periods specified above, such statement shall be final and
binding for all purposes hereof. 
 (e) Utilities for the Premises included as a part of Operating Expenses shall not include
utility charges and HVAC beyond the hours of 8:00 AM to 6:00 PM, Monday-Friday, and 8:00 AM to 1:00 PM on Saturday. Any usage by Tenant of HVAC and utilities at times other than the aforesaid hours shall be at the sole cost and expense of Tenant.
Landlord shall bill Tenant directly for all such costs as a separate item of Additional Rent, and Tenant shall pay such amounts within fifteen (15) days of receipt of demand for payment from Landlord, and the failure by Tenant to pay such costs
in accordance with the demand made by Landlord shall be treated in the same manner under this Lease as a non-payment of base rent by Tenant with Landlord being afforded the same rights and remedies for such non-payment. 
 Landlord shall calculate and incur Operating Expenses in a manner that is substantially consistent with previous years of the Lease Term.
Notwithstanding anything in the Lease to the contrary, but subject to the cap in management fees in Section 2(b)(ii), with the exception of “Uncontrollable Expenses” (defined as Real Estate Taxes, insurance premiums, utilities,
janitorial services, snow removal, landscaping, management fees, and charges assessed against the Building pursuant to any covenants or owner’s association). Increases in all other Operating Expenses that are not Uncontrollable Expenses (herein
“Controllable Expenses”) shall be limited to an eight percent (8%) per annum increase over the amount of the Controllable Expenses for the immediately preceding calendar year. Landlord shall use commercially reasonable efforts to
manage the Operating Expenses.” 
 (f) Tenant may make any payment due to Landlord under this Lease by check, wire or via
the Automated Clearing House (“ACH”) network. Landlord shall provide wiring instructions and/or ACH payment information upon request by Tenant. 
 4. Tenant Allowance. Provided that no uncured material nonmonetary default and no uncured monetary default by Tenant (of which Tenant has received notice and failed to cure prior to the expiration
of the applicable cure period) has occurred and is then continuing Landlord shall provide an allowance payable in cash to Tenant in three installments, which shall be due and payable on the

  

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following dates: $1,034,605.62 on March 31, 2010, $739,004.00 on June 30, 2013, and $739,004.00 on June 30, 2018 (the “Extension Allowance”). The Extension Allowance
shall, at the option of Tenant, be payable by check deliverable to the address for notices set forth in Article 20, or by wire pursuant to wiring instructions provided by Tenant. Notwithstanding anything to the contrary in the Lease or this
Amendment, Tenant, in its sole discretion, may use the Extension Allowance in any manner and for any purpose (whether or not related to the Premises or this Lease) Tenant deems appropriate, including, but not limited to, using the Extension
Allowance in connection with various alterations to the Premises or using the Extension Allowance to pay Tenant’s rent. Tenant acknowledges and agrees, that in the event Tenant, in its sole discretion, elects to use the Extension Allowance for
the construction and installation of any alterations to the Premises, such alterations shall be subject to and performed in accordance with Article 5 of the Lease. Tenant shall not be required to provide any accounting of Tenant’s use of
the Extension Allowance to Landlord. 
 5. Option to Renew. Section 1(c) of the Lease is hereby deleted in
its entirety and replaced with the following: 
 “(c). Options to Extend. 
 (a) Grant and Exercise of Option. Provided that no uncured material default by Tenant has occurred and is then continuing, Tenant
shall have the option to extend the Lease Term for two (2) additional periods of five (5) years each (the “Extension Term(s)”). Each Extension Term shall be upon the same terms and conditions contained in the Lease except
(x) this provision giving two (2) extension options shall be amended to reflect the remaining options to extend, if any, and (y) any improvement allowances or other concessions applicable to the Premises under the Lease shall not
apply to the Extension Term, and (z) the Base Annual Rent shall be adjusted as set forth below (the “Rent Adjustment”). Tenant shall exercise each option by delivering to Landlord, no later than six (6) months prior to the
expiration of the preceding term, written notice of Tenant’s desire to extend the Lease Term. Tenant’s failure to timely exercise such option shall be deemed a waiver of such option and any succeeding option. Landlord shall notify Tenant
of the amount of the Rent Adjustment no later than ninety (90) days prior to the commencement of the Extension Term. Tenant shall be deemed to have accepted the Rent Adjustment if it fails to deliver to Landlord a written objection thereto
within fifteen (15) days after receipt thereof. If Tenant properly exercises its option to extend, Landlord and Tenant shall execute an amendment to the Lease (or, at Landlord’s option, a new lease on the form then in use for the Building)
reflecting the terms and conditions of the Extension Term within thirty (30) days after Tenant’s acceptance (or deemed acceptance) of the Rent Adjustment. 
 (b) Rent Adjustment. The Base Annual Rent for the applicable Extension Term shall be an amount equal to
ninety-five percent (95%) of the Base Annual Rent then being received by Landlord from current tenants of the Building for space of comparable size and quality and with similar or equivalent improvements as are found in the Building, and if
none, then in similar buildings in the Park; provided, however, that in no event shall the Base Annual Rent during the applicable Extension Term be less than the highest Base Annual Rent payable during the immediately preceding term. The monthly
installments of Base Rent shall be an amount equal to one-twelfth ( 1/12) of the Base Annual Rent for the applicable Extension Term and shall be paid at the same time and in the same manner as provided in the Lease.” 
 6. Right of First Refusal. Section 1 (e) of the Lease shall remain in full force and effect. 
 7. Notices. Article 20 of the Lease is hereby amended as follows: With respect to Landlord and Tenant, the addresses for
notices are: 
  

 -5- 

			
	Landlord:	  	Duke Realty Limited Partnership
		  	c/o Duke Realty Corporation
		  	Attn.: Raleigh Market – Vice President,
		  	Asset Management & Customer Service
		  	3005 Carrington Mill Road, Suite 100
		  	Morrisville, NC 27560
		
	With a copy to:	  	Duke Realty Limited Partnership
		  	c/o Duke Realty Corporation
		  	Attn: Raleigh Market Attorney
		  	3950 Shackleford Road, Suite 300
		  	Duluth, GA 30096-8268
		
	With Payments to:	  	Duke Realty Limited Partnership
		  	75 Remittance Drive, Suite 3205
		  	Chicago, IL 60675-3205
		
	Tenant:	  	PPD Development, LP
		  	929 North Front Street
		  	Wilmington, NC 28401
		  	Attn: Corporate Site Services Administrator
		
	With a copy to:	  	PPD Development, LP
		  	929 North Front Street
		  	Wilmington, NC 28401
		  	Attn: General Counsel

 8. Brokers. Article 21 of the Lease is hereby deleted and replaced with
the following: 
 “21. BROKER’S CLAUSE. Except for UGL EQUIS CORPORATION, an Illinois corporation, representing
Tenant, whose commission shall be paid by Landlord, Landlord and Tenant each represents and warrants to the other that neither party has engaged or had any conversations or negotiations with any broker, finder or other third party concerning the
matters set forth in this Amendment who would be entitled to any commission or fee based on the execution of this Amendment. Landlord and Tenant each hereby indemnifies the other against and from any claims for any brokerage commissions and all
costs, expenses and liabilities in connection therewith, including, without limitation, reasonable attorneys’ fees and expenses actually incurred, for any breach of the foregoing. The foregoing indemnification shall survive the termination of
the Lease for any reason.” 
 9. Covenant of Tenant. Article 26 of the Lease is hereby amended by adding the
following provision to the end of the last sentence: “Notwithstanding anything to the contrary herein, in no event will Tenant be required to make any changes to the provisions in this Amendment regarding the Extension Allowance or any remedies
Tenant may have in the event of a failure to comply with such obligations.” 
 10. Landlord Transfer.
Section 27(g) of the Lease is hereby amended by adding the following provision: “As a condition of the release in this Section 27(g), Landlord and any such new owner shall enter into a written agreement acknowledging the
new owner’s obligations and liabilities of Landlord

  

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under this Lease that shall specifically include a statement that the new owner will comply with Landlord’s obligation to make the Extension Allowance payments as provided in
Section 4 of this Amendment.” 
 11. Miscellaneous. Section 27(m) of the Lease is hereby
amended by adding the following provision: “Notwithstanding anything to the contrary, Tenant shall be permitted to deduct any amount of the Extension Allowance that Landlord has failed to make against any rent payment due under the Lease,
including, but not limited to base rent or Additional Rent, regardless of whether any holder of a mortgage or beneficiary of a deed of trust, or any assignee thereof, takes over Landlord’s rights under this Lease.” 
 12. Tenant Remedies. Section 27(l) of the Lease is hereby amended by adding the following provision: “(iv)
Notwithstanding anything to the contrary in the Lease, in addition to any other remedies which may be available, in the event Landlord fails to make all or any portion of an installment payment of the Extension Allowance on the date specified in
this Lease, Tenant may, in its sole discretion, after giving Landlord written notice of such failure to make a payment and thirty (30) days to make the payment, credit the amount of the installment payment of the Extension Allowance that
Landlord has failed to make against any Annual Base Rent or Additional Rent that may be payable under the Lease.” 
 13.
Emergency Generator. 
 (a) Tenant, at its sole cost and expense and subject to the terms of the Lease, shall have the
right to operate and maintain the emergency generator and related equipment (collectively, the “Generator”) currently serving the Premises. Tenant shall operate and maintain the Generator in accordance with all federal, state and local
laws and regulations and with any protective covenants. Tenant shall be solely responsible for obtaining any necessary permits and licenses required to operate and maintain the Generator and shall provide copies thereof to Landlord. Tenant, at
Tenant’s sole cost and expense, shall maintain existing screening around the Generator. Tenant shall at all times keep the Generator and the surrounding area in a clean and orderly condition. 
 (b) Tenant, at its sole cost and expense, shall be responsible for removing the Generator and any screening surrounding the Generator and
for restoring the Building and/or common areas affected by the Generator and screening to their original condition after such removal, subject to reasonable wear and tear. Tenant agrees, within thirty (30) days after written notice from
Landlord, to remove the Generator and any screening surrounding same in the event any governmental entity or applicable law or regulation requires removal thereof or Tenant fails to materially comply with the terms stated herein within thirty
(30) days after such notice. Such removal shall be in accordance with all of the terms and conditions set forth herein. If Tenant fails to remove the Generator and screening surrounding same from the Building or Common Areas upon expiration or
earlier termination of the Lease, or after expiration of the thirty (30) day notice period provided above, the Generator and any screening surrounding same shall be deemed abandoned by Tenant and shall become the property of Landlord, or
Landlord may remove the same at Tenant’s expense. 
 14. Severability. In the event any term, covenant or condition
of this Amendment, the Lease, or any amendments thereto shall to any extent be invalid or unenforceable, the remainder shall not be affected thereby and each term, covenant or condition shall be valid and enforceable to the full extent permitted by
law. 
 15. Successors and Assigns. This Amendment shall apply to, inure to the benefit of, and be binding upon the
parties hereto and upon their respective heirs, legal representatives, successors and permitted assigns, except as otherwise provided herein. 
  

 -7- 

 16. Authority of Tenant. Tenant certifies to Landlord that it is authorized to enter
into this Amendment, and that those persons signing below on its behalf are authorized to do so, and shall promptly upon the request of Landlord provide a resolution to this effect. 
 17. Interpretation. Although the printed provisions of this Amendment were drafted by Landlord, such fact shall not cause this
Amendment to be construed either for or against Landlord or Tenant. All capitalized terms, not otherwise defined, shall be defined as provided in the Lease. 
 18. Full Force and Effect. Except as modified hereby, the Lease remains unmodified and in full force and effect. 
 19. Governing Law. This Amendment shall be governed by and construed in accordance with the laws of the State of North Carolina. 
 20. Mutual Acknowledgment of Non-Existence of Claims. Landlord and Tenant acknowledge and agree that as of the day hereof there are
no known claims by either party against the other party hereto arising from the relationship as Landlord and Tenant, respectively, pursuant to the Lease, as amended. 
 21. Confidentiality. Except as otherwise required by law to be disclosed by Tenant, the terms and provisions of the Lease and this Amendment are strictly confidential, are to be shared by Tenant
only with its accountant, employees, and attorneys, and each of those parties shall be advised of the confidential nature of the lease and this Amendment. 
 22. Memorandum of Lease. The parties agree that this Lease may not be recorded but that either party may request that the other execute a Memorandum of Lease which may be recorded. The parties
agree to remove the Memorandum of Lease of record upon the expiration or earlier termination of this Lease. In the event of an early termination as a result of Tenant’s default and vacation of the Premises, Tenant agrees that Landlord can
unilaterally remove the Memorandum of Lease of record. 
 [Execution signatures contained on the following page]

  

 -8- 

 IN WITNESS WHEREOF, the parties have caused this Amendment to be executed on the day and
year first written above. 
  

											
		 		 		 	LANDLORD:
				
		 		 		 	 DUKE REALTY LIMITED PARTNERSHIP,

		 		 		 	 an Indiana limited partnership doing business in North Carolina as Duke Realty of Indiana Limited
Partnership

					
		 		 		 	By:	 	 Duke Realty Corporation, an Indiana Corporation, its general partner

						
		 		 		 		 	By:	 	 /s/ Jeffrey B. Sheehan

		 		 		 		 		 	Jeffrey B. Sheehan
		 		 		 		 		 	Senior Vice President, Raleigh Operations
		 		 		 	 TENANT: 

				
		 		 		 	 PPD DEVELOPMENT LP, a Texas limited partnership

					
		 		 		 	By:	 	 PPD GP, LLC, a Delaware limited liability company, its General Partner

					
		 		 		 	By:	 	 /s/ William J. Sharbaugh

					
		 		 		 	Printed:	 	 William J. Sharbaugh

					
		 		 		 	Title:	 	 Chief Operating Officer

	
	 Guarantor hereby executes this Amendment to evidence its consent to the Amendment.

			
	 WITNESS:
	 		 	GUARANTOR:
				
		 		 		 	PHARMACEUTICAL PRODUCT
		 		 		 	DEVELOPMENT, INC., a North Carolina corporation
				
	 /s/ Charles H. Munn
	 		 	By:	 	 /s/ William J. Sharbaugh

	Print Name:	 	 Charles H. Munn
	 		 	Name:	 	William J. Sharbaugh
		 		 		 	Title:	 	Chief Operating Officer

  

 -9-

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