Document:

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                                                                   Exhibit 10.22
                               LICENSE AGREEMENT

     This License Agreement ("Agreement"), effective as of the 30th day of June,
1999 (the "Effective Date"), is entered into by and between Argonaut
Technologies, Inc., a Delaware corporation having offices at 887 Industrial
Road, Suite G, San Carlos, California 94070, U.S.A. ("Argonaut"), and The
Jackson Laboratory a non-profit corporation having offices at 600 Main Street,
Bar Harbor, Maine 04609-1500 ("Jackson").

                                   WITNESSETH

     A.   WHEREAS, Jackson is the owner of U.S. Patent 4, 911, 555, and has the
right to grant licenses under said Patent, subject only to a royalty-free,
nonexclusive license heretofore granted to the United States Government;

     B.   WHEREAS, Jackson desires to have the Patent developed and
commercialized to benefit the public and is willing to grant a license
thereunder;

     C.   WHEREAS, Argonaut has represented to Jackson, to induce Jackson to
enter into this License Agreement, that Argonaut is experienced in the
development production, manufacturing, marketing, and sale of products Similar
to Products (as later defined herein) and that it will commit itself to a
thorough, vigorous, and diligent program of exploiting the Patent so that
public utilization can result therefrom.

     D.   Jackson desires to grant to Argonaut the right to develop,
manufacture, and distribute Products (as defined below) using the Licensed
Patent (as defined below).

     1.   DEFINITIONS

     a. "Licensed Patent" means U.S. Patent 4,911,555, Magnetic Stirrer For
Multiple Samples including all revisions, extensions, substitutions,
re-registrations, examinations, re-validations and patents of additions as well
as any foreign patents covering any claims described in the foregoing patent.

     b. "Products" means any revenue producing product or part thereof which is
covered in whole or in part by an issued, unexpired claim of the Licensed
Patent, which is developed, manufactured, distributed or licensed by or through
Argonaut using the Licensed Patent, including that product specifically set
forth in Exhibit A.

     c. "Field" means all organic and inorganic reaction specific applications.

     d. "Revenue" means any funds or other consideration Argonaut actually
receives from the sale of the Products.

                                      -1-

<PAGE>   2
          e.   "Year" shall mean each twelve (12) month period following the
Effective Date.

     2.   LICENSE GRANT.

          a.   Licensed Patent. Jackson hereby grants to Argonaut a worldwide
Field exclusive, sub-licensable, worldwide license, under the Licensed Patent,
to develop, manufacture, have manufactured, modify, use, market, service, sell
and otherwise distribute the Products. Jackson reserves the right to practice
under the Patent solely for its own research purposes.

          b.   Distributors. Argonaut may exercise its distribution rights
granted pursuant to Section 2 above through the use of third party
distributors, resellers, dealers and sales representatives (collectively,
"Distributors").

     c.   Products. Argonaut agrees that Products leased or sold in the United
States shall be manufactured substantially in the United States.

     3.   PATENT NOTICES.

          Argonaut shall place appropriate patent markings on Products used,
sold or otherwise distributed hereunder during the term of this Agreement.

     4.   CONFIDENTIALITY.

          Each party agrees that the terms and conditions of this Agreement
shall be treated as Confidential Information; provided that each party may
disclose the terms and conditions of this Agreement; (i) as required by any
court or other government body or as otherwise required by law; (ii) to legal
counsel, employees, and trustees; (iii) in confidence, to accountants, banks,
and financing sources and their advisors; (iv) in confidence, in connection
with the enforcement of this Agreement or rights under this Agreement.

     5.   INDEMNIFICATION AND INTELLECTUAL PROPERTY

          a.   By Jackson. Jackson shall at Argonaut's request, notify Argonaut
of all countries in which it is seeking patents covering the Products. Jackson
shall promptly after discovery notify Argonaut of any material infringement of
which it becomes aware related to any patents covering the Products. Jackson
shall have the right to bring, defend, and maintain any appropriate suit, action
or proceeding involving any such infringement at Jackson's expense. In the event
that Jackson fails to take any such action in a reasonable time, Jackson shall
give Argonaut all authority, information and assistance necessary to pursue,
defend or settle any such suit, action or proceeding and Argonaut shall pay the
expenses (including attorneys' fees) incurred in connection with any such suit,
action or proceeding. In the event that Argonaut lack standing to bring any such
suit, action or proceeding, then Argonaut may, for such purposes, use the name
of Jackson as a party plaintiff

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provided that no settlement, consent judgment, or other voluntary final
disposition of the suit may be entered into without the consent of Jackson,
which consent shall not unreasonably be withheld. Any amounts recovered in any
suit, action or proceeding under this Section 5(a) by either party, whether by
judgment or settlement (including, but not limited to, any royalties or other
consideration received pursuant to any sublicenses or other arrangements
entered into as part of settlement), shall be retained by that party.

          b.   By Argonaut. Argonaut shall indemnify, hold harmless and, at
Jackson's request, defend Jackson from and against any and all claims,
liabilities and expenses (including reasonable fees of attorneys and other
professionals) arising out of or in connection with Argonaut's use,
manufacture, sale, lease, distribution, or advertisement of the Products,
provided Jackson promptly notifies Argonaut of any such claim and permits
Argonaut to control the defense and settlement thereof.

     6.   LIMITATION OF LIABILITY

          In no event shall either party be liable to the other party for any
special, incidental or consequential damages arising out of this Agreement,
the use of the Licensed Patent or distribution of Products by Argonaut or any
third party, whether under theory of contract, tort (including negligence),
indemnity, product liability or otherwise. Notwithstanding the foregoing, this
Section 6 shall not apply to Section 5(b) of this Agreement.

     7.   FIELD EXCLUSIVITY.

          Unless otherwise agreed in writing, Jackson shall only allow Argonaut
Field exclusive distribution rights for Products.

     8.   TECHNOLOGY LICENSE FEE.

          a.   Royalty. Unless otherwise agreed in writing, Argonaut agrees to
pay Jackson a per unit royalty for each of the Products.

          b.   Royalty Amount. Unless otherwise agreed in writing, the per unit
Royalty Amount will be set separately for each instrument as defined as
Products, as specifically set forth in Exhibit A.

          c.   Payment. Unless otherwise agreed in writing, Payment shall
include all Royalty Amounts for Products distributed in Argonaut's previous
quarter. The Payment will be made in USD to Jackson quarterly. The Payment
shall be made to Jackson sixty (60) days from the end of Argonaut's fiscal
quarter and shall include all Payments for Products distributed the previous
fiscal quarter.

     9.   TERM AND TERMINATION.

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          a.   Term.

               (i)  This Agreement shall continue in full force and effect until
the expiration of the Patent, unless earlier terminated as provided in Section
9(b).

               (ii) At the end of the Term, Argonaut retains all rights granted
hereunder. However, all obligations to pay the Royalty and Payments discontinue.

          b.   Termination.

          This Agreement will terminate automatically without notice, (i) upon
the institution by or against Argonaut of insolvency, receivership or
bankruptcy proceedings or any other proceedings for the settlement of
Argonaut's debts, (ii) upon Argonaut's making an assignment for the benefit of
creditors, or (iii) in the event of Argonaut's dissolution or insolvency. This
Agreement will also terminate should Argonaut fail to make any payment due and
payable to Jackson hereunder, or upon any material breach or default of this
Agreement by Argonaut, upon thirty (30) days notice. Upon the expiration of the
thirty (30) day period, if Argonaut shall not have made such payments or cured
any such material breach, the rights, privileges, and license granted hereunder
shall automatically terminate.

          c.   Survival. The parties' rights and obligations under Sections 1,
3, 4, 5, 6, 9(c) and 10 shall survive any termination of this Agreement.

          d.   No Waiver. The failure of either party to enforce any provision
of this Agreement shall not be deemed a waiver of such provision.

     10.  MISCELLANEOUS PROVISIONS.

          a.   Assignment. Neither party may transfer or assign its rights or
obligations under this Agreement without the prior written consent of the other
party. Subject to the foregoing sentence, this Agreement will be binding upon
and inure to the benefit of the parties hereto, their successors and assigns.
Successors of Argonaut shall include any party which acquires Argonaut or into
which Argonaut merges.

          b.   No Implied Waivers. The failure of either party at any time to
require performance by the other of any provision hereof shall not affect the
right of such party to require performance at any time thereafter, nor shall the
waiver of either party of a breach of any provision hereof be taken or held to
be a waiver of a provision itself.

          c.   Severability. If any provision of this Agreement is held to be
invalid by a court of competent jurisdiction, then the remaining provisions
will nevertheless remain in full force and effect. The parties agree to
renegotiate in

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<PAGE>   5
good faith those provisions so held to be invalid to be valid, enforceable
provisions which provisions shall reflect as closely as possible the original
intent of the parties, and further agree to be bound by the mutually agreed
substitute provision.

          d. Force Majeure. Except for payment of monies, neither party shall
be liable for failure to fulfill its obligations under this Agreement,
including, but not limited to, acts of God, manmade or natural disasters,
earthquakes, fire, riots, flood, material shortages, strikes, delays in
transportation or inability to obtain labor or materials through its regular
sources. The time for performance of any such obligations shall be extended for
the time period lost by reason of the delay.

          e. Conflicting Terms. The parties agree that the terms and
conditions of this Agreement shall prevail, notwithstanding contrary or
additional terms, in any purchase order, sales acknowledgement, confirmation or
any other document issued by either party effecting the purchase and/or sale of
Products, unless the parties agree otherwise in writing.

          f. Headings. Headings of paragraphs herein are inserted for
convenience of reference only and shall not affect the construction or
interpretation of this Agreement.

          g. Notice. Any notice required or permitted to be given under this
Agreement shall be delivered (i) by hand, (ii) by registered or certified mail,
postage prepaid, return receipt requested, to the address of the other party
first set forth above, or to such other address as a party may designate by
written notice in accordance with this Section 10(g), (iii) by overnight
courier, or (iv) by fax with confirming letter mailed under the conditions
described in (ii) above. Notice so given shall be deemed effective when
received, or if not received by reason of fault of addressee, when delivered.

          h. Entire Agreement. This Agreement contains the entire understanding
of the parties with respect to the subject matter hereof and supersedes all
prior agreements relating thereto, written or oral, between the parties.
Amendments to this Agreement must be in writing, signed by the duly authorized
officers of the parties. The terms of any purchase order are expressly excluded.

          i. Governing Law. This Agreement shall be governed by and construed
under the law of the State of Maine, without regard to conflict of laws
principles or the U.N. Convention on Contracts for the International Sale of
Goods.

          j. Arbitration. Any dispute or claim arising out of or in relation to
this Agreement, or the interpretation, making, performance, breach or
termination thereof, shall be finally settled by binding arbitration under the
Rules of

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conciliation and Arbitration of the International Chamber of Commerce as
presently in force ("Rules") and by three (3) arbitrators appointed in
accordance with said Rules. Judgment on the award rendered may be entered in any
court having jurisdiction thereof. The place of arbitration shall be Hancock
County, Maine, U.S.A. The parties may apply to any court of competent
jurisdiction for temporary or permanent injunctive relief, without breach of
this Section 10(j) and without any abridgment of the powers of the arbitrators.

     IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement
effective as of the Effective Date.

THE JACKSON LABORATORY                 ARGONAUT TECHNOLOGIES, INC.

By: /s/ KENNETH PAIGEN                 By: /s/ JAN K. HUGHES
    ------------------                     -------------------------------------
Name: Kenneth Paigen                   Name: Jan K. Hughes

Title: Director                        Title: Vice President Product Development

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                                   EXHIBIT A

                           PRODUCTS AND DOCUMENTATION

     Products:

A.   ENTRY LEVEL PARALLEL REACTOR SYSTEM

     1) Manual Parallel Organic and Inorganic Reactor System

        - Number of Reactors <24

        - Rotary Stir Magnet Mixing

        - Heating

        - Cooling

        - Inert Reaction Environment

        - Approximate Average Unit Revenue: USD 2,500.00

Royalty Amounts:

A.   ENTRY LEVEL PARALLEL REACTOR SYSTEM: USD 100.00 PER UNIT

                                      -7-<PAGE>   1
                                                                   EXHIBIT 10.23

                               LICENSE AGREEMENT

     THIS AGREEMENT, effective as of the first day of June, 1997, by and between
ARGONAUT TECHNOLOGIES, INC.,  a corporation of Delaware, having a place of
business at 887 INDUSTRIAL ROAD, SUITE G, SAN CARLOS, CA 94070 (hereinafter
"LICENSEE"), and Rohm and Haas Company, a corporation of the State of Delaware,
having a principal place of business at 100 Independence Mall West,
Philadelphia, Pennsylvania 19106 (hereinafter "LICENSOR").

                                  WITNESSETH:

     WHEREAS, LICENSOR is the owner of the U.S. Patents set forth in Schedule A
appended to this Agreement relating to porous or macroreticular adsorbents and
ion exchange resins which have found use in the FIELD;

     WHEREAS, LICENSEE wishes to obtain and LICENSOR is willing to grant
a non-exclusive, royalty-bearing license under these patents.

     NOW, THEREFORE, the parties intending to be legally bound agree as follows:

ARTICLE 1 - DEFINITIONS

     1.01 "PATENT RIGHTS" shall mean the U.S. patents listed in Schedule A
appended to this Agreement, or as later amended by written agreement of the
parties.

     1.02 "VALID CLAIM" shall mean a claim in any unexpired, issued patent of
the PATENT RIGHTS which has not been disclaimed, forfeited or held invalid or
unenforceable by a decision beyond the right of review.

     1.03  "RESIN" shall mean polymers covered by any VALID CLAIM or produced by
a process covered by any VALID CLAIM of the patents in Schedule A or produced by
a process covered by one or more of such claims and suitable for conversion to
PRODUCTS (as defined hereinafter).

     1.04  "PRODUCTS" shall mean RESIN (a) made and sold by LICENSEE after
incorporation of an active ingredient, or (b) made for Licensee under a legally
executed toll production agreement, wherein the
<PAGE>   2
RESIN may or may not incorporate an active ingredient, and subsequently used
or sold by LICENSEE to an END USER (as defined hereinafter).

     1.05 "FIELD" shall mean manual and automated synthesis of chemical
compounds excluding synthesis of industrial chemicals catalyzed by typical ion
exchange resins.

     1.06 "AFFILIATE" shall mean any entity in which at least forty-nine
percent (49%) of the stock normally entitled to vote for the election of
directors is directly or indirectly owned or controlled by LICENSEE.

     1.07 "GROSS PURCHASES" shall mean (a) the total cost of manufacture of
RESIN (not including addition of the active ingredient) including all raw
materials, intermediates, equipment amortization and labor costs, or (b) the
actual gross amounts of the invoices (less shipping costs, if any) covering all
of LICENSEE's PURCHASES of RESIN, including the value of any materials,
technology or know-how provided by the LICENSEE to any third party engaged in
the manufacture of RESIN for the LICENSEE, its customers or AFFILIATES.
PURCHASES are deemed to include RESIN provided for both internal use and resale,
after addition of active ingredient.

     1.08 "END-USER" shall mean any customer of LICENSEE which is not an
AFFILIATE or an INTERMEDIARY.

ARTICLE 2 - GRANT

     LICENSOR hereby grants to LICENSEE, and LICENSEE hereby accepts, subject
to the terms and conditions set forth in this Agreement, a non-exclusive
license under the PATENT RIGHTS to make or have made and use RESINS and sell
PRODUCTS, based on said RESINS in the FIELD.

ARTICLE 3 - MARKING

     LICENSEE shall mark labels, products literature, or packages for the
PRODUCTS with the following legend:
     "This product contains RESIN manufactured under one or more of the U.S.
Patent 4,297,220 and 4,382,124."

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ARTICLE 4 - PAYMENTS AND REPORTS

     4.01 For the rights granted under this Agreement, LICENSEE shall pay to
LICENSOR an initial sum of One Thousand Dollars ($1000), payable upon signing
of this Agreement, and royalties calculated as follows:

     (a) ten percent (10%) of GROSS PURCHASES of packed bottles of RESIN
         purchased by LICENSEE when RESIN is used to make PRODUCT for sale to
         END USERS,

     (b) fourteen percent (14%) of GROSS PURCHASES of bulk RESIN purchased by
         LICENSEE when RESIN is used to make PRODUCT for sale to END USERS, and

     (c) seven and one-half percent (7.5%) of GROSS PURCHASES of RESIN when
         RESIN is used to make PRODUCT for internal use.

     4.02 LICENSEE shall make written confidential reports to LICENSOR within
sixty (60) days after the end of each calendar quarter during the term of this
Agreement. Each report shall state the total volume and GROSS PURCHASES of
RESIN (a) purchased from toll manufacturers and (b) produced internally for
each category listed in 4.01. The royalty for all PRODUCTS purchased during each
calendar quarter shall be due and payable with the report for that quarter. Any
late payment of the royalty shall bear interest at the rate of one-and-one-half
percent (1 1/2%) per month.

     4.03 All payments and reports shall be sent to the following address:

               ROHM AND HAAS COMPANY
               ATTN: Corporate Licensing
               P.O. Box 8500 S-1150
               Philadelphia, PA 19178

     4.04 LICENSEE shall maintain sufficiently detailed books and records for
the PRODUCTS sold or used by LICENSEE and AFFILIATES to enable LICENSOR to
verify the payments made to LICENSOR by LICENSEE. LICENSEE shall permit an
accountant, appointed by LICENSOR and reasonably acceptable to LICENSEE, to
inspect, at reasonable times and upon reasonable notice, but not to exceed once
per year, the books and records of LICENSEE relating to the sale of the

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PRODUCTS for use in the FIELD. The accountant shall report to LICENSOR only
whether the amounts reported and paid to LICENSOR by LICENSEE are accurate. In
no event, however, shall an examination of LICENSEE's books be made for a period
prior to three (3) years before the date such audit is requested by LICENSOR. In
the event the accountant reports to LICENSOR that LICENSEE has underpaid the
amounts due to LICENSOR by more than ten percent (10%), LICENSEE shall bear the
cost of the audit.

     4.05 LICENSEE shall have no obligation to pay royalties under this
Agreement on PRODUCTS which LICENSEE has purchased from another licensee who has
already paid royalties on such PRODUCTS to LICENSOR under the PATENT RIGHTS,
provided that the rights granted to LICENSEE with the purchase of such PRODUCTS
shall not exceed those which the other licensee is entitled to extend to its
customers.

ARTICLE 5 - TERM AND TERMINATION

     5.01 This Agreement shall remain  in effect until the expiration of the
last patent to expire under the PATENT RIGHTS, unless terminated earlier as
provided in this Agreement.

     5.02 LICENSEE may terminate this Agreement and the licenses granted under
this Agreement by giving LICENSOR three (3) months prior written notice of
LICENSEE's intention to terminate.

     5.03 LICENSOR, at its discretion, may terminate this Agreement for one of
the following reasons by giving notice to LICENSEE.

     (1) If there is a sale, loss, transfer, or other disposition by LICENSEE of
         or execution or other legal process levied upon or enforced against all
         or a substantial portion of the assets of LICENSEE, or an action or
         proceeding is commenced by or against LICENSEE under any bankruptcy act
         or under any present or future law for the relief of debtors, or a
         receiver or trustee is appointed for LICENSEE or LICENSEE's assets, or
         an action or proceeding is commenced to dissolve LICENSEE, or LICENSEE
         makes an assignment for the benefit of creditors or ceases to carry on
         business for any reason; or

     (2) If LICENSEE fails to perform or observe any agreement, provision, duty
         or obligation under this Agreement, such as the

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<PAGE>   5
          timely reporting and payment of royalties, and does not remedy the
          failure within thirty (30) days after receipt of notice from LICENSOR,
          provided, however, that repeated failures by LICENSEE shall constitute
          and independent basis for LICENSOR to terminate this Agreement.

     5.04 The termination of this Agreement shall not prejudice any rights or
remedies which shall have accrued to either party prior to the date of such
termination.

ARTICLE 6 - ASSIGNMENT

     LICENSEE may assign this Agreement to an entity that acquires all of the
LICENSEE's business or assets to which this Agreement pertains, whether by
merger, reorganization, acquisition, sale or otherwise. This Agreement shall be
binding upon and inure to the benefits of the successors and permitted assigns
of the parties.

ARTICLE 7 - NOTICES

     Any notice required or provided for by the terms of this Agreement shall be
in writing. All notices shall be sent by first class mail, postage prepaid, to
the business address of the party to be given notice. The business addresses of
the parties shall be as follows:

                          ROHM AND HAAS COMPANY
                          100 Independence Mall West
                          Philadelphia, PA 19106
                          Attn: Director of Licensing

Either party may change its business address by notice to the other party.

ARTICLE 8 - MISCELLANEOUS

     8.01 This Agreement shall be construed and the legal relations between the
parties determined in accordance with the laws of the Commonwealth of
Pennsylvania.

     8.02 Neither party shall be deemed to have waived any of its rights under
this Agreement by failure to take any action to enforce any of its rights at any
particular time.

     8.03 This Agreement is the entire agreement between the parties and there
are no other terms, obligations, covenants, representations,

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statements or conditions, oral or otherwise, of any kind. This Agreement may not
be changed, modified, or amended in whole or in part except by a written
document signed by the duly-authorized officers of the parties.

     IN WITNESS WHEREOF, the parties have caused this Agreement to be executed
in duplicate to be effective as of 27 June, 1997.

                                             ROHM AND HAAS COMPANY

By: /s/ PAUL VAN EIKEREW                     By: /s/ PAUL BADUINI
    ----------------------------                 -----------------
Name: Paul Van Eikerew                       Name: Paul Baduini
      --------------------------                   ---------------
Title: Vice President, Chemistry             Title: Vice-President
       -------------------------                    --------------
Date: 27 June 1997                           Date: July 24, 1997
      --------------------------                   ---------------

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                                   SCHEDULE A

<TABLE>
<CAPTION>

Patent No.          Title                                       Expiration Date
----------          -----                                       ---------------
<S>                 <C>                                         <C>
U.S. 4,297,220      Macroreticulated Copolymer                  October 26, 1998
                    Adsorption Process

U.S. 4,382,124      Process for Preparing                            May 2, 2000
                    Macroreticular Resins
                    Copolymers and Products
                    of said Process
</TABLE>

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