Document:

EX-10.8

 Exhibit 10.8 

SUBLEASE AGREEMENT 
 This Sublease
Agreement (”Sublease”), dated December 27, 2017 (the “Effective Date”), is by and between Bio-Rad Laboratories, Inc., a Delaware corporation, having its principle
place of business at 1000 Alfred Nobel Drive, Hercules, California 94547 (”Sublandlord”), and Evelo Biosciences, Inc., a Delaware corporation, having an office at 620 Memorial Dr. #200, Cambridge, MA 02139
(”Subtenant”); 
 WHEREAS, Sublandlord is the tenant under that certain lease agreement dated December 5, 2014
(“Primary Lease”) with 620 Memorial Leasehold LLC, a Massachusetts limited liability company (”Prime Landlord”); and 

WHEREAS, pursuant to the Primary Lease, Sublandlord leased those certain premises (the “Premises”) more particularly described in the Primary
Lease and located in the building having a street address of 620 Memorial Drive, Cambridge, Massachusetts (“Building”); and 
 WHEREAS,
Sublandlord desires to sublease the Premises to Subtenant, and Subtenant desires to sublease the Premises from Sublandlord, in accordance with the terms and conditions of this Sublease. 

NOW, THEREFORE, in consideration of the mutual covenants, terms and conditions set forth herein, and for other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the parties agree as follows: 
 1. Demise. Sublandlord hereby leases to Subtenant, and
Subtenant hereby leases from Sublandlord, the Premises (also referred herein, as the “Subleased Premises”) shown on Exhibit A attached to and made a part of this Sublease, located on the first (1st), fourth (4th), and fifth (5th) floors of the Building and comprising the entire
Premises. The Sublease Premises is approximately 40,765 rentable square feet of space, consisting of approximately 12,691 rentable square feet on the fifth (5th) floor, approximately 21,034
rentable square feet on the fourth (4th) floor, and approximately 7,040 rentable square feet on the first (1st floor). 

2. Term. 
 (a) The
term of this Sublease (“Term”) shall commence on February 1, 2018 (the “Sublease Commencement Date”), and ending on September 30, 2025 (the “Sublease Expiration Date”),
unless sooner terminated or cancelled in accordance with the terms and conditions of this Sublease.
 (b) Subtenant
shall not be entitled to exercise any options to extend or renew the term of the Primary Lease. These options are expressly retained by Sublandlord and may be exercised or waived by Sublandlord in its sole and absolute discretion. 

(c) If for any reason the term of the Primary Lease is terminated prior to the Sublease Expiration Date, this Sublease
shall terminate on the date of such termination and Sublandlord shall not be liable to Subtenant for such termination. 
 3. Permitted Use.
Subtenant shall use and occupy the Subleased Premises solely in accordance with, and as permitted under, the terms of the Primary Lease and for no other purpose. 

  
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620 Memorial Drive Sublease/Evelo (12-15-17rev) 

 4. Payment of Base Rent and Additional Rent. 

(a) Throughout the Term of this Sublease, Subtenant shall pay to Sublandlord fixed base rent (“Base
Rent”) at a per annum rate from April 1, 2018 (the “Rent Commencement Date”) to the Sublease Expiration Date, as listed below, payable in equal monthly installments. Subtenant shall pay to Sublandlord
installments of Base Rent no less than five (5) business days prior to the date same is due under the Primary Lease. 
  

							
	 Rent Period
	  	 Per Annum
	  	 Per Square Feet
	  	 Monthly Installment

	 04/01/18 - 09/30/2018
	  	$2,700,681.25	  	$66.25	  	$225,056.77
	 10/01/2018 - 09/30/2019
	  	$2,781,701.69	  	$68.24	  	$231,808.47
	 10/01/2019 - 09/30/2020
	  	$2,864,964.20	  	$70.28	  	$238,747.02
	 10/01/2020 - 09/30/2021
	  	$2,950,913.13	  	$72.39	  	$245,909.43
	 10/01/2021 - 09/30/2022
	  	$3,039,640.54	  	$74.56	  	$253,303.38
	 10/01/2022 - 09/30/2023
	  	$3,130,752.00	  	$76.80	  	$260,896.00
	 10/01/2023 - 09/30/2024
	  	$3,224,919.15	  	$79.11	  	$268,743.26
	 10/01/2024 - 09/30/2025
	  	$3,321,532.20	  	$81.48	  	$276,794.35

 (b) In addition to Base Rent, commencing on the Sublease Commencement Date and
continuing throughout the Term of this Sublease, Subtenant shall pay to Sublandlord: 
  

	 	(i)	100% of the Parking Spaces at the then-current rates, as such rate may vary from time to time. (As of the Effective Date of this Sublease, the current rate is $200 per Parking Space.); 

 

	 	(ii)	100% of all costs paid directly by Sublandlord for electricity and other utilities for the Sublease Premises; and, 

  

	 	(iii)	All amounts due and payable by Sublandlord under the Primary Lease due or attributable to the Subleased Premises or the actions or omissions of Subtenant. 

(c) In addition to Base Rent, commencing on Sublease Commencement Date and continuing throughout the Term of this
Sublease, Subtenant shall pay to Sublandlord: 
 (i) 100% of Sublandlord’s share of Operating Costs under the
Primary Lease; 
 (ii) 100% of Sublandlord’s share of Taxes under the Primary Lease. 

The charges in subpart (b) and (c) are collectively, “Additional Rent.” Additional Rent shall be payable to Sublandlord
in monthly installments based on estimates provided by Sublandlord no less than ten (10) days prior to the date same is due under the Primary Lease. 

(d) All Base Rent and Additional Rent shall be due and payable without demand therefor unless otherwise designated by
Sublandlord and without any deduction, offset, abatement, counterclaim or defense. The monthly installments of Base Rent and Additional Rent payable on account of any partial calendar month during the Term of this Sublease, if any, shall be
prorated. Any other amount due under this Sublease shall be due and payable fifteen (15) days following Subtenant’s receipt of Sublandlord’s invoice therefor (which shall be accompanied by such reasonable backup as would enable
Subtenant to confirm the amount thereof). 

  
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620 Memorial Drive Sublease/Evelo (12-15-17rev) 

 5. Letter of Credit. Simultaneously with the execution and delivery of this Sublease by
Subtenant to Sublandlord, Subtenant shall deliver to Sublandlord a clean, irrevocable letter of credit in the amount of One Million Two Hundred Fifty Thousand and 00/100 Dollars ($1,250,000.00) (the “Letter of Credit Amount”) as
security for the full and faithful performance by Subtenant of Subtenant’s obligations hereunder and which shall comply with, and may be drawn by Sublandlord in accordance with, the provisions of Exhibit E attached
hereto (such letter of credit, together with any renewal or replacement thereof in accordance herewith, being referred to herein as the “Letter of Credit.” 

(a) Subject to subpart (b) and provided there is no Event of Default by the Subtenant at any time during the Term:
(i) during the period of time from April 1, 2020 through March 31, 2021 (both dates inclusive), the Letter of Credit Amount will be reduced to One Million and 00/100 Dollars ($1,000,000.00); and (ii) during the period of time
from April 1, 2021 through the Sublease Expiration Date (both dates inclusive), the Letter of Credit Amount will be further reduced to Eight Hundred Fifty Thousand and 00/100 Dollars ($850,000.00). 

(b) To effect a reduction of the Letter of Credit Amount as set forth above in subpart (a), Subtenant shall either
(x) deliver to Sublandlord a proposed consent to amendment to the Letter of Credit, which amendment shall be reasonably acceptable to the Sublandlord in all respects, reducing the amount of the Letter of Credit to the then-applicable Letter of
Credit Amount, or (y) deliver to Landlord a replacement Letter of Credit in the amount of the then-applicable Letter of Credit Amount, which replacement Letter of Credit shall in all respects comply with all of the requirements of this
Section 5. Within twenty (20) business days after delivery of either the proposed consent to an amendment to the Letter of Credit or proposed replacement Letter of Credit, Sublandlord will either (A) execute such consent in accordance
with the terms thereof, or provide its reasonable objections to such proposed consent or amendment, or (B) consent to the cancellation of the existing Letter of Credit and to the exchange of the replacement Letter of Credit for such existing
Letter of Credit. 
 6. Incorporation of Primary Lease by Reference. 

(a) The terms, covenants and conditions of the Primary Lease are incorporated herein by reference, except to the extent
they are expressly deleted or modified by the provisions of this Sublease. Every term, covenant and condition of the Primary Lease binding upon or inuring to the benefit of Prime Landlord shall, in respect of this Sublease, be binding upon or inure
to the benefit of Sublandlord and every term, covenant and condition of the Primary Lease binding upon or inuring to the benefit of Sublandlord shall, in respect of this Sublease, be binding upon and inure to the benefit of Subtenant. Whenever the
term “Lessor” appears in the Primary Lease, the word “Sublandlord” shall be substituted therefore; whenever the term “Lessee” appears in the Primary Lease, the word “Subtenant”
shall be substituted therefore; whenever the word “Premises” appears in the Primary Lease, the word “Subleased Premises” shall be substituted therefore. 

(b) Notwithstanding the foregoing, (i) the following numbered sections of the Primary Lease shall not apply to
this Sublease: Section 1.2 (Extension Terms); Section 1.7 (Early Termination Right); Section 3 (Condition of Premises; Construction); Section 6 (Expansion Option Prior to 

  
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620 Memorial Drive Sublease/Evelo (12-15-17rev) 

 
Term Commencement Date); Section 7 (ROFO); Section 13 (Assignment, Mortgage and Subletting); Section 24 (Notices), excepting as set forth below in Section 19 (Notices); and,
Exhibit 4 (Plans for Landlord’s Base Building Work); Exhibit 5 (Matrix); Exhibit 6; Exhibits 8A (Tenant’s Hazardous Materials); and, (ii) the time limits contained in the Primary Lease for Sublandlord, as tenant, to give notices, make
demands or perform any act, covenant or condition or to exercise any right, remedy or option, are modified herein by shortening the same in each instance by five (5) days. In case such time limits in the Primary Lease are for less than five
(5) days, those time limits are modified herein by shortening the same by fifty percent (50%). 
 7. Subordination to Primary Lease. This
Sublease is subject and subordinate to the Primary Lease. A redacted copy of the Primary Lease is attached hereto as Exhibit C and made a part of this Sublease.  

8. Representations of Sublandlord. Sublandlord represents and warrants the following is true and correct as of the date hereof: 

(a) Sublandlord is the tenant under the Primary Lease and has the capacity to enter into this Sublease with Subtenant.

 (b) The Primary Lease attached hereto as Exhibit C is a true, correct and complete copy of the Primary Lease,
is in full force and effect, and has not been further modified, amended or supplemented except as expressly set forth herein. 

(c) Sublandlord has not received any notice, and has no actual knowledge, of any default by Sublandlord under the Primary
Lease. To Sublandlord’s actual knowledge, Primary Landlord is not in default under the Primary Lease. 

9. AS-IS Condition. Subtenant accepts the Subleased Premises in its current,
“as-is” condition. Sublandlord shall have no obligation to furnish or supply any work, services, furniture, fixtures, equipment or decorations (other than the “Retained Furniture“as defined
herein), except Sublandlord shall deliver the Subleased Premises in broom clean condition and with existing Building systems serving the Premises in good working order. The obligations of Subtenant hereunder shall survive the expiration or earlier
termination of this Sublease. Notwithstanding the foregoing, Subtenant shall not be liable for any damage to the Subleased Premises caused by Sublandlord in connection with Sublandlord’s vacating the Subleased Premises. 

10. Alterations. Subtenant Alterations shall be subject to Section 11 of the Primary Lease. 

11. Performance by Sublandlord. Notwithstanding any other provision of this Sublease, Sublandlord shall have no obligation (a) to
furnish or provide, or cause to be furnished or provided, any repairs, restoration, alterations or other work, or electricity, heating, ventilation, air-conditioning, water, elevator, cleaning or other
utilities or services, or (b) to comply with or perform or, except as expressly provided in this Sublease, to cause the compliance with or performance of, any of the terms and conditions required to be performed by Prime Landlord pursuant to
the terms of the Primary Lease. Subtenant hereby agrees that Prime Landlord is solely responsible for the performance of the foregoing obligations, but in the event that such performance is interrupted, rent shall be abated hereunder to the extent
that rent is abated under the Primary Lease for such interruption. Notwithstanding the foregoing, upon the written request of Subtenant, Sublandlord shall make a written demand upon Prime Landlord 

  
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620 Memorial Drive Sublease/Evelo (12-15-17rev) 

 
to perform its obligations under the Primary Lease with respect to the Subleased Premises if Prime Landlord fails to perform same within the time frame and in the manner required pursuant to the
Primary Lease; provided, however, Subtenant shall not be required to bring any action against the Prime Landlord to enforce its obligations. In the event Sublandlord makes written demand upon Prime Landlord or brings an action against Prime Landlord
to enforce Prime Landlord’s obligations under the Primary Lease with respect to the Subleased Premises, all costs and expenses (including without limitation reasonable attorneys’ fees and expenses) so incurred by Sublandlord in connection
therewith shall be deemed Additional Rent and shall be due and payable by Subtenant to Sublandlord within ten (10) days after notice from Sublandlord. Sublandlord will, to the same extent it is relieved of its obligations to the Prime Landlord
as a result of non-performance by the Prime Landlord, relieve Subtenant. In no event shall Sublandlord be liable to Subtenant in damages, nor shall rent abate hereunder (except as stated in this
Section 11), for or on account of any failure by the Prime Landlord to perform the obligations and duties imposed on it under the Primary Lease. 

12. No Privity of Estate; No Privity of Contract. Nothing in this Sublease shall be construed to create privity of estate or privity of contract
between Subtenant and Prime Landlord. 
 13. No Breach of Primary Lease. Subtenant shall not do or permit to be done any act or thing, or omit to
do anything, which may constitute a breach or violation of any term, covenant or condition of the Primary Lease, notwithstanding such act, thing or omission is permitted under the terms of this Sublease. 

14. Subtenant Defaults. 

(a) If Subtenant fails to cure a default under this Sublease within any applicable grace or cure period contained
in the Primary Lease, Sublandlord, after five (5) days’ notice to Subtenant, shall have the right, but not the obligation, to seek to remedy any such default on the behalf of, and at the expense of, Subtenant, provided, however, that in
the case of: (i) a life safety or property related emergency; or (ii) a default which must be cured within a time frame set forth in the Primary Lease which does not allow sufficient time for prior notice to be given to Subtenant,
Sublandlord may remedy any such default without being required first to give notice to Subtenant. Any reasonable cost and expense (including without limitation reasonable attorneys’ fees and expenses) so incurred by Sublandlord shall be deemed
Additional Rent and shall be due and payable by Subtenant to Sublandlord within ten (10) business days after notice from Sublandlord. 

(b) If Subtenant fails to pay any installment of Base Rent or Additional Rent within five (5) days after the due date
of such payment, Subtenant shall pay to Sublandlord, as Additional Rent, a “late charge” equal to five percent (5%) of any delinquent amount overdue for the purposes of defraying the expense of handling such delinquent payment. 

(c) If Subtenant fails to pay any installment of Base Rent or Additional Rent within five (5) days from the due date
of such payment, in addition to the payment of the late charge set forth immediately above, Subtenant shall also pay to Sublandlord, as Additional Rent, interest at the Default Rate (hereinafter defined) from the due date of such payment to the date
payment is made. “Default Rate” shall mean a rate per annum equal to the lesser of: (i) ten percent (10%) or (ii) the highest rate of interest permitted by applicable laws. 

  
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620 Memorial Drive Sublease/Evelo (12-15-17rev) 

 15. Consents. 

(a) Whenever the consent or approval of Sublandlord is required, Subtenant shall also be obligated to obtain the written
consent or approval of Prime Landlord, if required pursuant to the terms of the Primary Lease. Sublandlord shall promptly make such consent request on behalf of Subtenant and Subtenant shall promptly provide any information or documentation that
Prime Landlord may request. Subtenant shall reimburse Sublandlord, not later than ten (10) days after written demand by Sublandlord, for any fees and disbursements of attorneys, architects, engineers or others charged by Prime Landlord in
connection with any consent or approval. Sublandlord shall have no liability of any kind to Subtenant for Prime Landlord’s failure to give its consent or approval. 

(b) Sublandord may not modify or amend the Primary Lease in a manner that would materially and adversely affect the Sublease
Premises or the Subtenant’s permitted use and occupancy thereof, without Subtenant’s prior written consent (except to the extent such modification or amendment is required by applicable law or regulations), which consent shall not be
unreasonably withheld, conditioned or delayed. For avoidance of doubt, the exercise of any rights under Section 15 (Casualty; Taking) of the Primary Lease shall not be deemed a violation of this Section 15(b). 

16. Assignment or Subletting. Subtenant shall not sublet all or any portion of the Subleased Premises or assign, encumber, mortgage, pledge or
otherwise transfer this Sublease (by operation of law or otherwise) or any interest therein, without the prior written consent of: (a) Sublandlord, which consent shall not be unreasonably withheld, conditioned or delayed, and (b) Prime
Landlord. Notwithstanding the foregoing, no such consent shall be required in the event of a Transfer (as defined in the Primary Lease) permitted without consent under Section 13.7 (Exceptions to Requirement for Consent) of the Primary Lease.

 17. Hazardous Materials. Subtenant’s Hazardous Materials list is attached hereto as Exhibit D and made a part of this Sublease. 

18. Surrender of the Subleased Premises. For the avoidance of doubt, Section 21.1 (Surrender) of the Primary Lease applies to the Sublease. 

19. Furniture. Throughout the Sublease Term, Subtenant shall have beneficial use of the furniture, fixtures and equipment (the “Retained
Furniture”). Subtenant hereby accepts the Retained Furniture in their “as is” condition, and acknowledges that while Sublandlord maintains ownership of the Retained Furniture during the Term, Sublandlord has made no
representations or warranties of any kind with respect to the Retained Furniture, other than to represent that same is owned by Sublandlord, free and clear of all security interests or chattel mortgages, or its condition, and Sublandlord shall have
no obligation to Subtenant at any time for any repair or replacement with respect to the Retained Furniture. Subtenant shall, at its sole cost and expense, maintain and repair the Retained Furniture using a qualified third party vendor, so that the
Retained Furniture is in substantially the same condition and repair on the Expiration Date as it was on the date hereof, reasonable wear and tear and damage from Casualty (to the extent such Casualty is covered by Section 15 (Casualty; Taking)
of the Primary Lease) excepted. 

  
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620 Memorial Drive Sublease/Evelo (12-15-17rev) 

	 	(a)	If Subtenant elects to remove or dispose of any Retained Furniture during the Sublease Term, Subtenant shall notify Sublandlord of the same and provided Sublandlord does not remove the same from the Subleased Premises
within thirty (30) days following receipt of such notice from Subtenant, Subtenant shall have the right to remove or dispose of the same without obligation or liability to Sublandlord. 

 

	 	(b)	At the end of the Sublease Term, the Retained Furniture that has not been removed or disposed of during the term shall become the property of Subtenant. For the purposes herein, “Retained Furniture”
means all furniture, fixtures, and equipment listed on Exhibit D, attached hereto and incorporated herein by reference. Sublandlord shall, prior to the Sublease Commencement Date, remove all furniture, fixtures and equipment located within
the Premises and not listed on Exhibit D. 

 20. Indemnity. For the avoidance of doubt, the obligations of Section 14.2
(Indemnification) to the Primary Lease shall apply to each of the respective parties to this Sublease. 
 21. Release. Subtenant hereby releases
Sublandlord or anyone claiming through or under Sublandlord by way of subrogation or otherwise. Subtenant hereby releases Prime Landlord or anyone claiming through or under Prime Landlord by way of subrogation or otherwise to the extent that
Sublandlord releases Prime Landlord pursuant to the terms of the Primary Lease. Subtenant shall cause its insurance carriers to include any clauses or endorsements in favor of Sublandlord, Prime Landlord and any additional parties, which Sublandlord
is required to provide pursuant to the provisions of the Primary Lease. 
 22. Notices. All notices and other communications required or
permitted under this Sublease shall be given in the same manner as in the Primary Lease. Notices shall be addressed to the addresses set forth below: 
  

			
	To Subtenant prior to the Commencement Date at:	  	The above address.
		
	To Subtenant after the Commencement Date at:	  	 Evelo Biosciences, Inc.
 620 Memorial Drive,
Fifth Floor,
 Cambridge, MA 02139
 Attn: Chief Financial
Officer

		
	To Sublandlord at:	  	 Bio-Rad Laboratories, Inc.

1000 Alfred Nobel Drive
 Hercules, California 94547

Attn: Director, Global Real Estate and Facilities

		
	With a copy to:	  	 Bio-Rad Laboratories, Inc.

1000 Alfred Nobel Drive
 Hercules, CA 94547

Attn: General Counsel
 Fax: 510-741-5815

  
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620 Memorial Drive Sublease/Evelo (12-15-17rev) 

 23. Brokers. Sublandlord and Subtenant each represent to the other that it has not dealt with any
other broker other than Colliers International (“Subtenant’s Broker”) and McCall & Almy (“Sublandlord’s Broker,” and collectively with Subtenant’s Broker, “Broker”) in
connection with this Sublease and the transactions contemplated hereby. Sublandlord shall compensate Subtenant’s Broker and Sublandlord’s Broker each in accordance with a separate agreement. Sublandlord and Subtenant each indemnify and
hold harmless the other from and against all claims, liabilities, damages, costs and expenses (including without limitation reasonable attorneys’ fees and other charges) arising out of any claim, demand or proceeding for commissions, fees,
reimbursement for expenses or other compensation by any person or entity who shall claim to have dealt with the indemnifying party in connection with the Sublease other than Broker. This Section 23 shall survive the expiration or earlier
termination of this Sublease. 
 24. Defined Terms. All capitalized terms not otherwise defined in this Sublease shall have the definitions
contained in the Primary Lease. 
 25. Choice of Law. This Sublease shall be governed by, and construed in accordance with, the laws of the
Commonwealth of Massachusetts, without regard to conflict of law rules. 
 26. Time is of the Essence. Time is of the essence with each provision of
this Sublease. 
 27. Successors and Assigns. The covenants and agreement contained in this Sublease shall bind and inure to the benefit of
Sublandlord and Subtenant and their respective permitted successors and assigns. 
 28. Counterparts. This Sublease may be executed in any number
of counterparts, each of which when so executed and delivered shall be deemed an original for all purposes, and all such counterparts shall together constitute but one and the same instrument. A signed copy of this Sublease delivered by either
facsimile or e-mail shall be deemed to have the same legal effect as delivery of an original signed copy of this Sublease. 

29. Amendments and Modifications. This Sublease may not be modified or amended in any manner other than by a written agreement signed by the party
to be charged. 
 30. Entire Agreement. This Sublease contains the entire agreement between the parties with respect to the subject matter
contained herein and all prior negotiations and agreement are merged herein. In the event any provisions of this Sublease are held to be invalid or unenforceable in any respect, the validity, legality or enforceability of the remaining provisions of
this Sublease shall remain unaffected. 
 31. Precondition – Prime Landlord Consent to Sublease. This Sublease is expressly conditioned upon
obtaining the written consent of Prime Landlord (“Prime Landlord Consent”). If the Prime Landlord Consent is not obtained within thirty (30) days from the Effective Date above, either party may terminate this Sublease upon ten
(10) days prior written notice to the other, whereupon Sublandlord shall promptly refund all deposits and letters of credits to Subtenant, and neither party shall have any further obligation to the other under this Sublease. 

[SIGNATURE ON NEXT PAGE] 

  
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620 Memorial Drive Sublease/Evelo (12-15-17rev) 

 IN WITNESS WHEREOF, the parties hereto have executed this Sublease as of the Effective Date
above. 
  

									
	SUBLANDLORD:	 		 	SUBTENANT:
			
	Bio-Rad Laboratories, Inc.	 		 	Evelo Biosciences, Inc.
					
	By	 	 /s/ Carla Evans
	 		 	By	 	 /s/ Jennifer Glennon

	Name: Carla Evans	 		 	Name: Jennifer Glennon
	Title: Director Global RE & Facilities	 		 	Title: Vice President, Finance and Operations

  
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620 Memorial Drive Sublease/Evelo (12-15-17rev) 

 EXHIBIT A 

[DESCRIPTION OF SUBLEASED PREMISES] 

  
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620 Memorial Drive Sublease/Evelo (12-15-17rev) 

 

 

  

 

 

  

 

 

  

 EXHIBIT B 

[PRIMARY LEASE] 
  

  
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620 Memorial Drive Sublease/Evelo (12-15-17rev) 

 Exhibit C 

Subtenant’s Hazardous Materials 
  

											
	PV-1 Performance Verification Solution	  	Thermo Scientific	  	0.5	  	ml	  	?	  	202A, under fume hood
	SDS Micropellets	  	Fisher	  	100	  	g	  	1	  	202A, under fume hood
	SigmaClean water bath treatment	  	Sigma	  	4	  	oz	  	1	  	202A, under fume hood
	Sodium azide	  	Fisher	  	100	  	g	  	1	  	202A, under fume hood
	Sodium butyrate	  	SAFC	  	4	  	L	  	1	  	202A, under fume hood
	Sodium hydroxide	  	Fisher	  	3	  	kg	  	1	  	202A, under fume hood
	Sodium hydroxide	  	Spectrum	  	2.5	  	kg	  	1	  	202A, under fume hood
	Sodium hydroxide, 10N solution	  	Fisher	  	1	  	L	  	5	  	202A, under fume hood
	Sulfuric acid	  	Sigma-Aldrich	  	100	  	ml	  	3	  	202A, under fume hood
	Trypan blue solution (0.4%)	  	Sigma	  	100	  	ml	  	1	  	202A, under fume hood
	Trypan blue stain (0.4%)	  	Life Technologies	  	100	  	ml	  	1	  	202A, under fume hood
	Ultima Gold AB	  	PerkinElmer	  	1	  	L	  	1	  	202A, under fume hood
	Glycerol	  	Fisher	  	1	  	L	  	1	  	Fume hood 169224

  

 Exhibit D 

Retained Furniture 
  

					
	Item	  	Quantity	  	Description
			
	Reception Desk	  	1	  	Oak, U-shaped desk 9’x7’
			
	Chrome Metal Shelving	  	2	  	Rolling, 4’x2’x 6’8”
			
	Chrome Metal Shelving	  	2	  	Rolling, 5’x2’x 6’8”
			
	Chrome Metal Shelving	  	1	  	Rolling, 3’x18’ x 6’8”
			
	Chemical Hoods	  	5	  	6 foot chemical hoods
			
	Chemical Hoods	  	1	  	4 foot chemical hoods
			
	Black, Lab Table	  	2	  	Rolling, 2’x3’ with no drawers
			
	Black Lab Table	  	5	  	Rolling, 2’x3’ with 1 drawer
			
	Black Lab Table	  	3	  	Rolling, 2’6“x3’ with 3 drawers
			
	Black Lab Table	  	2	  	Rolling, 2’6“x3’ with no drawers
			
	Black Lab Table	  	2	  	Rolling 2’6“x5’ with 6 drawers
			
	Black Lab Table	  	1	  	Rolling, 2’6“x5’ with 3 drawers
			
	Black Lab Table	  	1	  	Non-rolling, 2’x3’ with 5 drawers
			
	Black Lab Table	  	1	  	Non-rolling, 2’x3’ with no drawers
			
	Black Lab Table	  	2	  	Non-rolling, 2’x3’ with 5 drawers
			
	Black Lab Table	  	3	  	Non-rolling, 2’x6’ with 6 drawers
			
	Black Lab Table	  	2	  	Rolling, 2’6“x5’ with 2 cabinets
			
	Black Lab Table	  	5	  	Rolling, 2’x6’ with 3 drawers
			
	Black Lab Table	  	2	  	Rolling, 2’x3’ with 6 drawers
			
	Black Lab Table	  	8	  	Rolling, 2’x3’ with 5 drawers
			
	Black Lab Table	  	2	  	Rolling, 2’6“x5’ with 1 cabinet
			
	Black Lab Table	  	2	  	Non-rolling, 2’x6’ with 3 drawers
			
	Black Lab Table	  	3	  	Non-rolling, 2’x6’ with 9 drawers
			
	Black Lab Table	  	1	  	Non-rolling, 2’x5’ with 2 cabinets
			
	Black Lab Table	  	3	  	Non-rolling, 2’x6’ with no drawers
			
	Black Lab Table	  	2	  	Non-rolling, 2’6“x5’ with no drawers
			
	Black Lab Table	  	1	  	Non-rolling, 2’6“x6’ with no drawers
			
	Black Lab Table	  	3	  	Rolling, 2’x6’ with no drawers
			
	Black Lab Table	  	1	  	Non-rolling, 2’6“x4’ with no drawers
			
	Black Lab Table	  	1	  	Rolling, 2’6“x5’ with 3 cabinets
			
	Black Lab Table	  	1	  	Non-rolling, 2’6“x5’ with 3 cabinets
			
	Black Lab Table	  	1	  	Non-rolling, 3’x4’ table with no drawers
			
	Black Lab Table	  	1	  	Rolling, 2’6“x6’ w/electrical above on 2 poles

  

 EXHIBIT E 

LETTER OF CREDIT REQUIREMENTS 

This Exhibit is attached to and made a part of the Sublease Agreement dated as of December
            , 2017 (the “Sublease”) by and between Bio-Rad Laboratories, Inc., a Delaware corporation
(“Sublandlord”), and Evelo Biosciences, Inc., a Delaware corporation (“Subtenant”), for space in the Building located at 620 Memorial Drive, Cambridge, Massachusetts 02139. Capitalized terms used but not defined
herein shall have the meanings given in the Sublease and the Primary Lease, as applicable. 
 The Letter of Credit (as defined in the
Sublease) shall be for the amount set forth in the Sublease, subject to the terms of Section 5 (Letter of Credit) of the Sublease. The Letter of Credit (i) shall be irrevocable and shall be issued by a commercial bank that has a financial
condition reasonably acceptable to Landlord and has an office in California that accepts requests for draws on the Letter of Credit, (ii) shall require only the presentation to the issuer of a certificate of the holder of the Letter of Credit
stating that Sublandlord is entitled to draw on the Letter of Credit pursuant to the terms of the Sublease, (iii) shall be payable to Sublandlord or its successors in interest as the Sublandlord and shall be freely transferable without cost to
any such successor or any lender holding a collateral assignment of Sublandlord’s interest in the Sublease, (iv) shall be for an initial term of not less than one year and contain a provision that such term shall be automatically renewed
for successive one-year periods unless the issuer shall, at least forty five (45) days prior to the scheduled expiration date, give Sublandlord notice of such nonrenewal, and (v) shall otherwise be
in form and substance reasonably acceptable to Sublandlord. Notwithstanding the foregoing, the term of the Letter of Credit for the final period shall be for a term ending not earlier than the date forty five (45) days after the last day of the
term. In the event that the issuer ceases to be reasonably acceptable to Sublandlord, due to a deterioration in its financial condition or change in status that threatens to compromise Sublandlord’s ability to draw on the Letter of Credit as
determined in good faith by Sublandlord, then Subtenant shall provide a replacement Letter of Credit from an issuer satisfying the terms of this Exhibit within thirty (30) days after Sublandlord’s notice of such event. 

Sublandlord shall be entitled to draw upon the Letter of Credit for its full amount or any portion thereof if (a) Subtenant shall fail to
perform any of its obligations under the Sublease after the expiration of any applicable notice and cure period, or fail to perform any of its obligations under the Sublease and transmittal of a default notice or the running of any cure period is
barred or tolled by applicable law, or fail to perform any of its obligations under the Sublease and any applicable notice and cure period would expire after the expiration of the Letter of Credit, or (b) not less than thirty (30) days
before the scheduled expiration of the Letter of Credit, Subtenant has not delivered to Sublandlord a new Letter of Credit in accordance with this Exhibit. Without limiting the generality of the foregoing, Sublandlord may, but shall not be obligated
to, draw on the Letter of Credit from time to time in the event of a bankruptcy filing by or against Subtenant and/or to compensate Sublandlord, in such order as Sublandlord may determine, for all or any part of any unpaid Base Rent, unpaid
Additional Rent, and/or any damages arising from any termination of the Sublease in accordance with the terms of the Sublease, and/or any damages arising from any rejection of the Sublease in a bankruptcy proceeding commenced by or against
Subtenant. Sublandlord may, but shall not be obligated to, apply the amount so drawn to the extent necessary to cure Subtenant’s failure. 

  
 14 

620 Memorial Drive Sublease/Evelo (12-15-17rev) 

 Any amount of the Letter of Credit drawn in excess of the amount applied by Sublandlord to cure
any such failure shall be held by Sublandlord as a cash security deposit for the performance by Subtenant of its obligations under the Sublease. Any cash security deposit may be mingled with other funds of Sublandlord and no fiduciary relationship
shall be created with respect to such deposit, nor shall Sublandlord be liable to pay Subtenant interest thereon. If Subtenant shall fail to perform any of its obligations under the Sublease, Sublandlord may, but shall not be obliged to, apply the
cash security deposit to the extent necessary to cure Subtenant’s failure. After any such application by Sublandlord of the Letter of Credit or cash security deposit, as the case may be, Subtenant shall reinstate the Letter of Credit to the
amount originally required to be maintained under the Sublease, upon demand. Provided that Subtenant is not then in default under the Sublease, and no condition exists or event has occurred which after the expiration of any applicable notice or cure
period would constitute such a default, within forty five (45) days after the later to occur of (i) the payment of the final Base Rent, Additional Rent or any other amount due from Subtenant or (ii) the later to occur of the Sublease
Expiration Date or the date on which Subtenant surrenders the Subleased Premises to Sublandlord in compliance with Section 21 of the Primary Lease, the Letter of Credit and any cash security deposit, to the extent not applied, shall be returned
to the Subtenant, without interest. 
 Subtenant further covenants that it will not assign or encumber or attempt to assign or encumber the
Letter of Credit or the monies deposited herein as security, and that neither Sublandlord nor its successors or assigns shall be bound by any assignment, encumbrance, attempted assignment or attempted encumbrance. 

  
 15 

620 Memorial Drive Sublease/Evelo (12-15-17rev)EX-10.9

 Exhibit 10.9 

Duncan McHale 
 TERMS
AND CONDITIONS OF EMPLOYMENT 
 Employer’s name and address: Evelo Biosciences, Inc. of 620 Memorial Dr., Suite 200 West, Cambridge MA 02139
(the “Company”) 
 Employee’s name and address: Duncan McHale of XXXXX (the “Employee”) 

In terms of the Employment Rights Act 1996 (the “Act”) this document gives details of your terms and conditions of employment with the
Company together with other workplace information, as at 15 December 2017 
  

	1.	JOB TITLE AND DUTIES 

  

	1.1	You are employed as Chief Medical Officer with effect from 15 December 2017. Your continuous employment started on this date. 

  

	1.2	You will perform all duties required of you by the board of directors of the Company (the “Board”). 

  

	1.3	Whilst employed by the Company you must: 

  

	 	(a)	during your hours of work devote all of your time, attention and abilities to the business of the Company and carry out your duties with due care and attention; 

 

	 	(b)	not, without the Company’s prior written consent, be in any way directly or indirectly engaged or concerned with any other business or employment (with the exception of Weatherden Limited) whether during or outside
your hours of work for the Company; 

  

	 	(c)	use your best efforts to promote and protect the interests of the Company and its subsidiaries and affiliates (each a “Group Company” and together the “Group”) and observe the utmost good faith
towards the Company and the Group; and 

  

	 	(d)	comply with all the Company’s rules, regulations and policies from time to time in force and any rules which the Company’s clients may require you to observe whilst working on their premises.

  

	2.	COMMENCEMENT OF EMPLOYMENT 

  

	2.1	Your period of continuous employment with the Company commenced on 15 December 2017. 

  

	2.2	This Agreement shall become effective on the consummation of the Company’s initial public offering of stock pursuant to an effective registration statement filed under the Securities Act of 1933, as amended (the
“Effective Date”)” 

  

	2.3	No employment with a previous employer counts as part of your period of continuous employment with the Company. 

  

	3.	REMUNERATION 

  

	3.1	Your gross basic salary is £300,000 per annum (or such other sum as agreed from time to time). The salary will be paid after deduction of all taxes and national insurance contributions and is payable in equal
monthly instalments into your nominated bank account on or around the last working day of each month. 

  

					
		  	1	  	WRITTEN TERMS (LONG)

	3.2	Your salary will be reviewed at regular intervals. 

  

	3.3	For the purposes of the Employment Rights Act 1996, sections 13-27, you agree that the Company may deduct from your remuneration any sums due from you to the Company including,
without limitation, your pension contributions (if any) and any overpayments, loans or advances made to you by the Company. 

  

	3.4	The Company may, at its absolute discretion pay you an annual, performance-based bonus upon the achievement of certain performance goals determined by the Board from time to time (the “Bonus”). The
terms and amount of this Bonus (and whether it is paid in cash or in other forms, such as shares or share options) will be approved from time to time and notified to you by the Board in its sole discretion. In determining whether a bonus is to be
paid, and if so the size of that bonus the Board may take into account such factors as it considers, in its absolute discretion, to be appropriate, which may include the anticipated future performance or service and/or past performance of you and/or
the Company and/or the Group, although it has no obligation to take any of these factors into account. The bonus will not accrue, nor will you have any legitimate expectation as to the size or form of the discretionary bonus, until the Company pays
it to you. There are no circumstances whether in reliance on express or implied terms or otherwise where you can require pay out of a particular sum or payment in a particular form or claim compensation for loss of such a bonus. Upon the termination
of your employment or (if earlier) upon either party giving notice of termination you will have no rights as a result of this Agreement or any alleged breach of it to any compensation under or in respect of any bonus scheme. 

 

	4.	EXPENSES 

 The Company shall reimburse to you (against receipts or other appropriate
evidence as the Company may require) the amount of all out-of-pocket expenses reasonably and properly incurred by you in the proper performance of your duties hereunder
in accordance with the Company’s expenses policy in force from time to time. 
  

	5.	NORMAL HOURS OF WORK 

  

	5.1	You will be expected to work a minimum of 40 hours per week with such additional hours as are necessary for the performance of your duties. 

 

	5.2	You may from time to time be required to work additional hours in order to properly perform your duties and/or allow the Company to meet its obligations to its clients. You are not entitled to additional remuneration
for authorised hours worked in excess of your normal hours.  

  

	5.3	In particular, you agree to work hours that exceed the maximum average weekly working time limit of 48 hours imposed by the Working Time Regulations 1998. You may withdraw your agreement on giving to the Company 3
months’ prior written notice. 

  

	6.	PLACE OF WORK 

  

	6.1	Your normal place of work will be Weatherden Limited, 93 Jack Straws Lane, Oxford, OX3 0DW England but the Company may change your normal place of work on giving you at least one month’s notice of any permanent
change to your normal place of work. 

  

	6.2	You may be required to work at any of the Company’s premises or at the premises of its customers, clients, suppliers or associates around the world from time to time. 

 

	6.3	You may be required to work overseas for periods exceeding one month, however there are currently no particulars to be entered in this regard. 

	7.	NOTICE 

  

	7.1	The length of prior written notice that you must give the Company in order to terminate your employment is 3 months. 

  

	7.2	The Company must give you 3 months’ notice to terminate your employment.  

  

	7.3	The Company reserves the right in its absolute discretion to terminate your employment immediately either instead of or at any time after notice of termination is given by either party and to make a payment in lieu of
notice. For this purpose, pay in lieu of notice will be a sum equal to only your salary that you would have received during the period of notice outstanding on the termination of your employment. For the avoidance of doubt, the Company’s right
to make a payment in lieu of notice does not give you a right to receive such a payment in lieu of notice. 

  

	7.4	The Company may, at its absolute discretion, require you not to attend at work and/or not to undertake all or any of your duties hereunder during any period of notice (whether given by the Company or you), provided
always that the Company shall continue to pay your salary and contractual benefits. For the avoidance of doubt, there is no obligation on the Company to provide you with any work during any period of notice and you will not be entitled to work on
your own account or on account of any other person, firm or company during that period. 

  

	7.5	The Company may, notwithstanding any other terms of your employment and irrespective of whether the grounds for termination arose before or after your employment began, at any time by notice in writing, terminate your
employment with immediate effect (without any prior period of notice, payment in lieu of notice or payment of any Severance Payments) and without compensation if:- 

 

	 	(a)	if you are convicted of a criminal offence other than one which in the opinion of the Board does not affect your position as an employee of the Company, bearing in mind the nature of your duties and the capacity in
which you are employed; 

  

	 	(b)	you are guilty of any serious default or misconduct in connection with or affecting the business of the Group, commit any serious or repeated breach of your obligations under your employment, are guilty of serious
neglect or negligence in the performance of your duties or behave in a manner (whether on or off duty) which is likely to bring the Group into disrepute or which seriously impairs your ability to perform your duties; 

 

	 	(c)	in the reasonable opinion of the Company, you have failed to substantially perform your duties to the Company (other than such failure resulting from any material illness that you are suffering) (provided that, to the
extent such failure can be cured, the Company shall have provided you with at least 30 days’ notice of such failure and you have not remedied the failure in the 30-day period); 

 

	 	(d)	in the reasonable opinion of the Company, you have failed in any material respect to carry out or comply with any lawful and reasonable directive of the Board consistent with the terms of this Agreement (provided that
to the extent such failure can be cured, the Company shall have provided you with at least 30 days’ notice of such failure and you have not remedied the failure in the 30-day period); 

 

	 	(e)	you are found to be using or under the influence of, or in possession of illegal drugs on the Company’s (or any Group Company’s) premises or while performing your duties under this Agreement;

  

	 	(f)	you do not have the right to work in the UK or you lose the right to work in the UK; 

  

	 	(g)	you are found guilty of misconduct by any applicable regulatory body or tribunal or any successor bodies. 

	8.	HOLIDAYS AND HOLIDAY PAY 

  

	8.1	You are entitled, to 28 days’ paid holiday in each holiday year (inclusive of all customary and public holidays recognised by the Company). 

 

	8.2	The Company’s holiday year runs from 1st January to 31st December. 

  

	8.3	If your employment begins or ends part way through the holiday year your holiday entitlement for that year will be assessed on a pro rata basis. 

 

	8.4	On termination of your employment you will be entitled to pay in lieu of any holidays which have accrued to you in the holiday year in which the termination takes place but which you have not taken at that time. The
Company may require you to take unused holidays during your notice period. If on the termination of your employment, you have taken holidays in excess of the statutory holiday entitlement which has accrued to you at that time you will be required to
repay to the Company holiday pay in respect of those holidays. 

  

	8.5	Holidays must be taken at times agreed by the Company and sufficient notice of a request to take holiday must be given to the Company. 

 

	8.6	All holidays must be taken in the holiday year in which they accrue and cannot be carried over to the next holiday year without the prior consent of the Company. 

 

	9.	SICKNESS OR OTHER ABSENCE 

  

	9.1	If you are absent from work for any reason and your absence has not previously been authorised by the Company you must inform the Company by 9am on your first day of absence. 

 

	9.2	In respect of absence due to sickness, injury or accident that continues for more than 7 consecutive days (including weekends) you must provide the Company with a medical certificate stating the reason for the absence.
Thereafter medical certificates must be provided to the Company to cover the remainder of the period of continuing sickness absence. Failure to follow these requirements may result in disciplinary action and loss of Statutory Sick Pay and company
sick pay. 

  

	9.3	If you are absent from work due to sickness, injury or accident and comply with the requirements in this Clause you will be paid: 

  

	 	(a)	Statutory Sick Pay in accordance with the provisions of the applicable legislation. For the purposes of Statutory Sick Pay, the “qualifying days” are Monday to Friday inclusive; and 

 

	 	(b)	At the discretion of the Board, Company sick pay equal to full salary for the first 2 weeks’ of absence due to sickness or injury in each calendar year. 

 

	9.4	Payment of Company sick pay shall be made less an amount equivalent to any Statutory Sick Pay payable to you. 

  

	9.5	The Company reserves the right to require you to undergo a medical examination conducted by a doctor nominated by the Company, at the Company’s expense. 

 

	9.6	If the sickness, injury or accident is caused by the act or omission of a third party you must, at the Company’s request, include in any claim for damages against such third party a claim in respect of moneys paid
by the Company under this Clause 9.6 and must refund to the Company any damages recovered under that head. 

	10.	PENSION ARRANGEMENTS AND OTHER BENEFITS 

  

	10.1	Pensions arrangements  

  

	 	(a)	During the period of your employment with the Company, the Company will comply at all times with the employer duties under Part 1 of the Pensions Act 2008. 

 

	 	(b)	You are eligible to join the group personal pension scheme initiated by the Company (the “Scheme”) subject to its rules from time to time in force. Details of the Scheme are available from
the Company. If you contribute a sum equivalent to at least 1% of his basic salary annually to the Scheme, then the Company will make an annual contribution to the Scheme of an amount equal to 1% of your basic salary. The contribution shall be paid
to the Scheme at such time or times during each year as the Company shall decide at its discretion. 

  

	10.2	Company’s right to terminate pensions arrangements 

 The Company shall be entitled
at any time to terminate the Scheme or your membership of it subject to providing him with membership of an equivalent pension scheme, the benefits of which shall be materially the same as the benefits provided to you under the Scheme. 

 

	10.3	Other Benefits 

 You will receive a payment of £10,000 per annum in lieu of any
private medical and dental expenses insurance, permanent health assurance and life assurance arrangements. This will be paid monthly and will be subject to deductions and appropriate taxation. 

 

	11.	CONFIDENTIALITY 

 You must not (except in the proper performance of your duties) while
employed by the Company or at any time (without limit) after the date on which your employment with the Company terminates: 
  

	 	(a)	divulge or communicate to any person; 

  

	 	(b)	use for your own purposes or for any purposes other than those of the Company or, as appropriate, any of its clients; or 

  

	 	(c)	through any failure to exercise due care and diligence, cause any unauthorised disclosure of; 

any trade secrets or confidential information relating to the Company or any Group Company or any of its clients. You must at all times use
your best endeavours to prevent publication or disclosure of any trade secrets or confidential information. These restrictions shall cease to apply to any information which shall become available to the public generally otherwise than through the
default by you. 
  

	12.	DATA PROTECTION 

 By signing this Statement, you acknowledge and agree that the Company
is permitted to hold and process personal (and sensitive) information and data about you as part of its personnel and other business records; and may use such information in the course of the Company’s business. You agree that the Company may
disclose such information to third parties, including where they are situated outside the European Economic Area, in the event that such disclosure is in the Company’s view required for the proper conduct of the Company’s business or that
of any associated company. This Clause applies to information held, used or disclosed in any medium. 

	13.	COMPANY AND CLIENT PROPERTY 

 All equipment (including computer equipment), notes,
memoranda, records, lists of customers, suppliers and employees, correspondence, computer and other discs or tapes, data listings, codes, keys and passwords, designs, drawings and other documents or material whatsoever (whether made or created by
you or otherwise and in whatever medium or format) relating to the business of the Company or a group company or any of its or their clients (and any copies of the same) shall: 

 

	 	(a)	be and remain the property of the Company or the relevant client; and 

  

	 	(b)	be handed over by you to the Company on demand and in any event on the termination of your employment. 

  

	14.	SEVERANCE PAYMENTS 

  

	14.1	In this Clause 14, unless the context otherwise requires, “Change in Control” means a “Change in Control” as defined in the Company’s 2018 Incentive Award Plan. 

 

	14.2	If your employment with the Company is terminated by the Company other than pursuant to Clause 7.5, then subject to the following conditions of this Clause 14 and in addition to any entitlement you may have to prior
notice of termination of employment under Clause 7, you will be entitled to the following payments and benefits (each a “Severance Entitlement”):- 

 

	 	(a)	if there has not been a Change in Control in the period of 12 months before the date of termination of the employment (the “Termination Date”), you shall be entitled to the payment of:

  

	 	(i)	6 months’ basic salary, paid in equal instalments in accordance with the Company’s ordinary payroll practices over the 6 months following the Termination Date; and 

 

	 	(ii)	£7,500 in lieu of the continuation of any contractual benefits, paid in equal instalments in accordance with the Company’s ordinary payroll practices over the 6 months following the Termination Date.

  

	 	(b)	if there has been a Change in Control in the period of 12 months before the Termination Date, you shall be entitled to the following payments and benefits: 

 

	 	(i)	all unvested equity or equity-based awards under any Company equity compensation plans that vest solely based upon the passage of time shall immediately become 100% vested on the Termination Date (for the avoidance of
doubt, with any such awards that vest in whole or in part based upon the attainment of performance vesting conditions being governed by the terms of the applicable award agreement); 

 

	 	(ii)	9 months’ basic salary, paid in equal instalments in accordance with the Company’s ordinary payroll practices over the 9 months following the Termination Date; 

 

	 	(iii)	100% of your target annual bonus for the year in which the Termination Date occurs, paid in equal instalments in accordance with the Company’s ordinary payroll practices over the 9 months following the Termination
Date; and 

	 	(iv)	£10,000 in lieu of the continuation of any contractual benefits, paid in equal instalments in accordance with the Company’s ordinary payroll practices over the 9 months following the Termination Date.

  

	14.3	The Severance Entitlements are together in full and final settlement of all and any rights and claims that you may have against the Company or any Group Company (as defined in clause 15) arising out of your employment
or the termination of your employment (including both contractual and statutory employment claims). You agree to waive, release and discharge any and all such rights and claims and acknowledge that it is a condition of the payment or provision of
the Severance Entitlements that you will execute a settlement agreement (and any other documents reasonably required by the Company) in a form reasonably acceptable to the Company in order to give effect to the release and waiver in this Clause
14.3. 

  

	14.4	You acknowledge that the Company has agreed to the terms of this Clause 14 in reliance on the undertakings that you have given in Clauses 11 and Clause 15. If you are in breach of any of the terms of Clause 11 or Clause
15, then you will have no entitlement to any Severance Entitlement; and if your beach of any of the terms of Clause 11 or Clause 15 occurs after any payment of provision to you of any Severance Entitlement then you will repay to the Company,
immediately upon demand by the Company, the value of all of the Severance Entitlements received by you and the Company shall be entitled to recover the same as a debt. 

 

	15.	RESTRICTIONS AFTER TERMINATION 

  

	15.1	Definitions 

 Since you are likely to obtain confidential information relating to the
Company and its business in the course of your employment and personal knowledge of and influence over suppliers, customers, clients and employees of the Company and Group Companies, you hereby agree with the Company that in addition to the other
terms of this Agreement and without prejudice to the other restrictions imposed upon you by law, you will be bound by the covenants and undertakings contained in Clauses 15.2 to 15.7. In this Clause 14, unless the context otherwise requires: 

 

			
	“Customer”	  	means any person to which the Company distributed, sold or supplied Restricted Products or Restricted Services during the Relevant Period and with which, during that period either you, or any employee under your direct or indirect
supervision, had material dealings in the course of your employment, but always excluding therefrom, any division, branch or office of such person with which you and/or any such employee had no dealings during that period;
		
	“Group”	  	means together or separately the Company, any holding company or undertaking of the Company and any subsidiaries and subsidiary undertakings of the Company or such holding company or undertaking from time to time (and the words
“subsidiary” and “holding company” shall have the meanings given to them in section 1159 in the Companies Act 2006;
		
	“Group Company”	  	means any company within the Group;
		
	“Prospective Customer”	  	means any person with which the Company had discussions during the Relevant Period regarding the possible distribution, sale or supply of Restricted Products or Restricted Services and with which during such period you, or any
employee who was under your direct or indirect supervision, had material dealings in the course of your employment, but always excluding therefrom any division, branch or office of that person with which you and/or any such employee had no dealings
during that period;

			
	“Relevant Period”	  	means: (i) where your employment is continuing, the period of your employment; and (ii) where your employment has terminated, the period of twelve months immediately preceding the Termination Date;
		
	“Restricted Area”	  	 means:
  

(a)   England, Scotland, Wales; and

 
 (b)   any other country in the
world where, on the Termination Date, the Company dealt in Restricted Products or Restricted Services;

		
	“Restricted Employee”	  	means any person who was a director, employee or consultant of the Company at any time within the Relevant Period who by reason of that position and in particular his seniority and expertise or knowledge of confidential information
or knowledge of or influence over the clients, customers or contacts of the Company is likely to cause damage to the Company if he were to leave the employment of the Company and become employed by a competitor of the Company;
		
	“Restricted Period”	  	means the period commencing on the Termination Date and, subject to the terms of Clause 15.4, continuing for 12 months;
		
	“Restricted Products”	  	means any products, equipment or machinery researched into, developed, manufactured, supplied, marketed, distributed or sold by the Company and with which your duties were materially concerned or for which you were responsible
during the Relevant Period, or any products, equipment or machinery of the same type or materially similar to those products, equipment or machinery;
		
	“Restricted Services”	  	means any services researched into, developed or supplied by the Company and with which your duties were materially concerned or for which you were responsible during the Relevant Period, or any services of the same type or
materially similar to those services;
		
	“Supplier”	  	means any supplier, agent, distributor or other person who, during the Relevant Period was in the habit of dealing with the Company and with which, during that period, you, or any employee under your direct or indirect , had
material dealings in the course your employment.

  

	15.2	Restrictive covenants 

 Both during your employment and during the Restricted Period, you
will not, without the prior written consent of the Company (such consent not to be unreasonably withheld), whether by yourself, through your employees or agents and whether on your own behalf or on behalf of any person, directly or indirectly: 

 

	 	(a)	so as to compete with the Company, solicit business from or canvas any Customer or Prospective Customer in respect of Restricted Products or Restricted Services; 

	 	(b)	so as to compete with the Company, accept orders from, act for or have any business dealings with, any Customer or Prospective Customer in respect of Restricted Products or Restricted Services; 

 

	 	(c)	within the Restricted Area, be employed or engaged in that part of a business or person which is involved in the business of researching into, developing, manufacturing, distributing, selling, supplying or otherwise
dealing with Restricted Products or Restricted Services, if the business or person is or seeks to be in competition with the Company. For the purposes of this sub-clause, acts done by the you outside the
Restricted Area shall nonetheless be deemed to be done within the Restricted Area where their primary purpose is to distribute, sell, supply or otherwise deal with Restricted Products or Restricted Services in the Restricted Area; 

 

	 	(d)	solicit or induce or endeavour to solicit or induce any person who was a Restricted Employee (and with whom you had dealings during the Relevant Period) to cease working for or providing services to the Company, whether
or not any such person would thereby commit a breach of contract; 

  

	 	(e)	employ or otherwise engage any Restricted Employee in the business of researching into, developing, manufacturing, distributing, selling, supplying or otherwise dealing with Restricted Products or Restricted Services if
that business is, or seeks to be, in competition with the Company; or 

  

	 	(f)	solicit or induce or endeavour to solicit or induce any Supplier to cease to deal with the Company and shall not interfere in any way with any relationship between a Supplier and the Company. 

 

	15.3	Application of restrictive covenants to other Group Companies 

 Clause 15.2 shall also
apply as though references to the “Company” in Clauses 15.1 and 15.2 include references to each Group Company in relation to which you have in the course of your employment or by reason of rendering services to or holding office in such
Group Company: 
  

	 	(a)	acquired knowledge of its products, services, trade secrets or confidential information; or 

  

	 	(b)	had personal dealings with its Customers or Prospective Customers; or 

  

	 	(c)	supervised directly or indirectly employees having personal dealings with its Customers or Prospective Customers; 

but so that references to the “Company” shall for this purpose be deemed to be references to the relevant Group Company. The
obligations undertaken by you pursuant to this Clause 15.3 shall, with respect to each Group Company, constitute a separate and distinct covenant in favour of and for the benefit of each Group Company and which shall be enforceable either by the
particular Group Company or by the Company on behalf of the Group Company and the invalidity or unenforceability of any such covenant shall not affect the validity or enforceability of the covenants in favour of any other Group Company. 

 

	15.4	Effect of suspension on Restricted Period 

 If the Company exercises its right to suspend
the your duties and powers under Clause 7.4 after notice of termination of your employment has been given, the aggregate of the period of the suspension and the Restricted Period shall not exceed 12 months and if the aggregate of the two periods
would exceed 12 months, the Restricted Period shall be reduced accordingly. 

	15.5	Further undertakings 

 You hereby undertake to the Company that you will not at any time:

  

	 	(a)	during your employment or after the Termination Date engage in any trade or business or be associated with any person engaged in any trade or business using any trading names used by the Company or any Group Company
including the name(s) or incorporating the word(s) “Evelo Biosciences” ; 

  

	 	(b)	after the Termination Date make any public statement in relation to the Company or any Group Company or any of their officers or employees; or 

 

	 	(c)	after the Termination Date represent or otherwise indicate any association or connection with the Company or any Group Company or for the purpose of carrying on or retaining any business represent or otherwise indicate
any past association with the Company or any Group Company. 

  

	15.6	Protection of Company reputation 

 You undertake that, you will not at any time during
your employment and at any time (without limit) after the Termination Date make or publish or cause to be made or published to anyone in any circumstances any disparaging remarks concerning the Company or any Group Company or any of its or their
respective shareholders, officers, employees or agents. 
  

	15.7	Employment Offer 

 In the event that you receive an offer of employment or request to
provide services either during your employment or during the terms of the Restrictive Period set out in Clause 15.1, you shall: 
  

	 	(a)	provide immediately to such person, company or other entity making such an offer or request a full and accurate copy of the Restrictive Covenants set out at Clause 15 of this Agreement; and 

 

	 	(b)	notify the Company within 3 working days of receipt of the offer and the identity of the person, company or other entity making the offer. 

 

	15.8	Severance 

 The restrictions in this Clause 15 (on which you have had the opportunity to
take independent advice, as you hereby acknowledge) are separate and severable restrictions and are considered by the parties to be reasonable in all the circumstances. It is agreed that if any such restrictions, by themselves, or taken together,
shall be adjudged to go beyond what is reasonable in all the circumstances for the protection of the legitimate interests of the Company or a Group Company but would be adjudged reasonable if some part of it were deleted, the relevant restriction or
restrictions shall apply with such deletion(s) as may be necessary to make it or them valid and enforceable. 
  

	16.	GRIEVANCE AND DISCIPLINARY MATTERS 

  

	16.1	If you have any grievance relating to your employment you may apply in writing to any director of the Company. 

  

	16.2	The director will consider your grievance and report to you within 7 days of the date when the grievance was raised. 

	16.3	If that report is not acceptable to you, you may then, within 7 days of receipt by you of the report, refer the matter in writing to CEO who will notify you of their decision within 14 days and whose decision will be
final and binding. 

  

	16.4	The disciplinary rules applicable to you are contained in the staff handbook. 

  

	16.5	If you are dissatisfied with any decision of the Company regarding any disciplinary matter, you may apply in writing to the CEO within 5 days of the decision to have that decision
re-considered in accordance with the Company’s appeals procedure. The appeals procedure is set out in full in the staff handbook. 

 

	16.6	The grievance, disciplinary and appeals procedures are not contractually binding on the Company and the Company may alter them, or omit any or all of their stages where it considers it appropriate. 

 

	17.	COLLECTIVE AGREEMENTS 

 There are no collective agreements applicable to you or which
affect your terms of employment. 
  

	18.	CHANGES TO TERMS OF EMPLOYMENT 

  

	18.1	The Company reserves the right to make changes to any of your terms and conditions of employment. 

  

	18.2	You will be given not less than one month’s written notice of any significant changes that may be given by way of an individual notice. Such changes will be deemed to be accepted unless you notify the Company of
any objection in writing before the expiry of the notice period. 

  

	19.	PREVIOUS CONTRACTS 

 The contractual terms in this Statement shall be in substitution for
all or any existing contracts of employment entered into between you and the Company which cease to have effect on the date upon which you commence work under this Statement. 
  

	20.	CONDITIONS TO EMPLOYMENT AND CONTINUED EMPLOYMENT 

  

	20.1	It is a condition of your employment with the Company that you are and remain legally entitled to reside and work in the United Kingdom. You confirm that you are legally entitled to work in the United Kingdom without
holding a work permit. Should it be discovered that you do not have permission to live and work in the United Kingdom or if any such permission is revoked, the Company reserves the right to terminate your employment forthwith without notice or pay
in lieu of notice and without referring to the warning stages of the Company’s disciplinary procedure. 

  

	21.	PRIVACY OF COMMUNICATION 

  

	21.1	All communications, whether by telephone, email, fax, or any other means, which are transmitted, undertaken or received using the Company’s IT or communications systems (“Company Systems”) or on
Company premises will be treated by the Company as work related. The Company Systems are provided for your work use only. You agree that the Company may intercept, record and monitor all communications made by you and your use of the Company Systems
without further notice. You should not regard any communications or use as being private. 

	21.2	The interception, recording and monitoring of communications is intended to protect the Company’s business interests for example, for the purposes of quality control, security of the Company Systems, protection of
the Company’s confidential information and legitimate business interests, record-keeping and evidential requirements, detection and prevention of criminal activity or misconduct and to assist the Company to comply with relevant legal
requirements. 

  

	21.3	You acknowledge and agree that all communications, data, records and files stored on the Company Systems or on the Company’s premises may be used as evidence in disciplinary or legal proceedings against you.

  

	22.	GOVERNING LAW AND JURISDICTION 

 This Statement is governed by and to be construed in
accordance with English law and any dispute is subject to the non-exclusive jurisdiction of the English courts. 

 IN WITNESS of which this Agreement has been executed and delivered as a deed on the first date written
above. 
  

							
	 EXECUTED as a Deed
 by EVELO BIOSCIENCES,
INC.
	  		 	 /s/ Balkrishan (Simba) Gill, Ph.D.

Director
	  	
	 acting by Balkrishan (Simba) Gill,

Ph.D. and Jonathan Poole
 ([Director/Secretary]
	  		 	  
 /s/ Jonathan Poole
	  	
	  	 	  
 Director/Secretary
	  	
				
	 EXECUTED as a Deed
 by DUNCAN
MCHALE
	  		 	  
 /s/ Duncan McHale
	  	
	in the presence of:	  		 		  	
				
	Witness’s	  		 		  	
				
	Signature:	  		 	  
	  	
				
	Full Name:	  		 	  
	  	
				
	Address:

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