Document:

Form of Restricted Stock Agreement

  
 Exhibit 10.4

 PAREXEL International Corporation 
 RESTRICTED STOCK AGREEMENT 
 THIS AGREEMENT (the
“Agreement”) is entered into as of <@GrDt+C@> (the “Award Date”) by and between PAREXEL International Corporation, a Massachusetts corporation (the “Company”) and <@Name+C
                     @>, a member of the Board of Directors of the Company, hereinafter referred to as the “Participant.”

 WHEREAS, the Company has adopted the PAREXEL International Corporation 2007 Stock Incentive Plan (as it may be amended from
time to time, the “Plan”), the terms of which are hereby incorporated by reference and made a part of this Agreement; and 
 WHEREAS, Section 7 of the Plan provides for the issuance of awards of the Company’s common stock, par value $0.01 per share (“Common Stock”), subject to certain restrictions
(“Restricted Stock”); and 
 WHEREAS, the Nominating and Corporate Governance Committee of the Board of
Directors of the Company (the “Board”) and the full Board have determined that it would be to the advantage and in the best interest of the Company and its stockholders to award shares of Restricted Stock to the Participant pursuant to the
terms and conditions set forth herein; and 
 NOW, THEREFORE, in consideration of the mutual covenants herein contained and
other good and valuable consideration, receipt of which is hereby acknowledged, the parties hereto do hereby agree as follows: 

ARTICLE I 

DEFINITIONS 
 1.1 In
General. Capitalized terms used but not defined herein shall have the meanings assigned to such terms in the Plan.
 1.2
“Restrictions” shall mean the restrictions on sale or other transfer set forth in Section 4.2 and the exposure to forfeiture set forth in Section 3.1. 
 ARTICLE II 
 RESTRICTED STOCK AWARD 

2.1 Award of Restricted Stock. In consideration of the Participant’s services on the Board, in exchange for the promises contained herein,
and for other good and valuable consideration which the Board has determined exceeds the aggregate par value of the shares of Common Stock subject to the Award (as defined below), as of the Award Date, the Company issues to the Participant the
number of shares of Restricted Stock set forth on the signature page hereof (the “Award”). 
 2.2 Award Subject to
Plan. The Award granted hereunder is subject to the terms and provisions of the Plan, including without limitation Section 10 thereof. 

  
 ARTICLE III

 RESTRICTIONS 
 3.1 Forfeiture. Except as otherwise provided by Section 3.2(b) or (c) below, any portion of an Award that is not vested at the time the Participant ceases to serve on the Board for any
reason shall thereupon be forfeited immediately and without further action by the Company. 
 3.2 Vesting and Lapse of
Restrictions.
 (a) Subject to Section 3.1, the Award shall vest in full on the first anniversary of the Award Date (the
“Vesting Date”) if the Participant is serving on the Board on such date. 
 (b) If the Participant dies or becomes
permanently and totally disabled (within the meaning of Section 22(e)(3) of the Code) prior to the Vesting Date and while the Participant is serving on the Board, the Award shall vest in full upon the date of the Participant’s death or
disability. 
 (c) If, prior to the Vesting Date, the Participant ceases to serve on the Board for any reason other than removal
for cause, a portion of the Award shall vest on the last day of Board service in an amount equal to the product of (a) the total number of shares of Restricted Stock subject to the Award and (b) the quotient of (i) the number of days
elapsed between the Award Date and the date the Participant’s service on the Board ended, divided by (ii) 365 (rounded down to the nearest whole share). All remaining unvested shares shall thereupon be forfeited immediately and without
further action by the Company. 
 3.3 Legend. Until such time as Restrictions have lapsed, the Company may, at any time, place
legends referencing the Restrictions and any applicable federal and/or state securities laws restrictions on certificates representing shares of Restricted Stock issued pursuant to this Agreement. The legend may include the following:

 “THE SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO RESTRICTIONS SET FORTH IN THE AWARD AGREEMENT BETWEEN THE
CORPORATION AND THE REGISTERED HOLDER, A COPY OF WHICH IS ON FILE AT THE PRINCIPAL OFFICE OF THE CORPORATION.” 
 “THE
SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AND MAY NOT BE SOLD, TRANSFERRED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT OR AN
OPINION OF COUNSEL SATISFACTORY TO THE CORPORATION TO THE EFFECT THAT SUCH REGISTRATION IS NOT REQUIRED.” 
 3.4 Payment of Taxes;
Issuance of Shares. 
 (a) Participant understands, acknowledges and agrees that the value of the Restricted Stock is
subject to state and federal income taxes and certain rules which require the Company to withhold amounts necessary to pay these taxes. If the Company in its discretion determines that it is obligated to withhold any tax in connection with the
vesting or transfer of the Award or any shares of the Restricted Stock, or the making of a distribution or other payment with respect to the Restricted Stock, participant hereby authorizes the Company to, in the

  
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Company’s discretion, (i) reduce the number of shares of Restricted Stock (or other property) delivered to Participant at the time the restrictions lapse by the number of shares of
Restricted Stock (or other property) required to satisfy the tax withholding requirements (based on the fair market value of shares or other property at such time), or (ii) withhold from the Participant’s board fees the appropriate amount
of tax. Such shares of Restricted Stock withheld pursuant to clause (i) above shall be returned to the Company. Participant’s acknowledgement and acceptance of these tax withholding provisions are conditions precedent to the
right of Participant to receive the Restricted Stock under the Plan and this Agreement. 
 (b) In lieu of either the
reduction of shares or other property delivered or the withholding of board fees described in paragraph (a) above, Participant may pay to the Company the amount of tax required to be withheld in cash, by check or in other form satisfactory to
the Company. Such payment must be made by the date on which the Restrictions lapse or such later date as is established by the Company (not to exceed 15 days after the date on which the Restrictions lapse). 

(c) The Shares will be released to the Participant when vested and the applicable withholding obligations have been satisfied.

 3.5. Certain Changes in Capitalization and Reorganization Events. Section 9 of the Plan shall govern the treatment of the
Award in the event of certain Changes in Capitalization and Reorganization Events. 
 3.6 Section 83(b) Election. Participant
understands that Section 83(a) of the Code taxes as ordinary income the difference between the amount, if any, paid for the shares of Common Stock and the Fair Market Value of such shares at the time the Restrictions on such shares
lapse. Participant understands that, notwithstanding the preceding sentence, Participant may elect to be taxed at the time of the Award Date, rather that at the time the Restrictions lapse, by filing an election under Section 83(b) of the
Code (an “83(b) Election”) with the Internal Revenue Service within 30 days of the Award Date. In the event Participant files an 83(b) Election, Participant will recognize ordinary income in an amount equal to the difference between
the amount, if any, paid for the shares of Common Stock and the Fair Market Value of such shares as of the Award Date. Participant further understands that an additional copy of such 83(b) Election form should be filed with his or her federal income
tax return for the calendar year in which the date of this Agreement falls. Participant acknowledges that the foregoing is only a summary of the effect of United States federal income taxation with respect to the award of Restricted Stock
hereunder, and does not purport to be complete. PARTICIPANT FURTHER ACKNOWLEDGES THAT THE COMPANY IS NOT RESPONSIBLE FOR FILING THE PARTICIPANT’S 83(b) ELECTION, AND THE COMPANY HAS DIRECTED PARTICIPANT TO SEEK INDEPENDENT ADVICE REGARDING THE
APPLICABLE PROVISIONS OF THE CODE, THE INCOME TAX LAWS OF ANY MUNICIPALITY, STATE OR FEDERAL GOVERNMENT OR FOREIGN COUNTRY IN WHICH PARTICIPANT MAY RESIDE, AND THE TAX CONSEQUENCES OF PARTICIPANT’S DEATH. 

ARTICLE IV 

OTHER PROVISIONS 
 4.1
Stock Certificates. Stock certificates issued in respect of this Award shall be registered in the name of the Participant and shall be deposited in escrow with the escrow agent appointed by the Company; provided, however, that in no
event shall the Participant retain physical custody 

  
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of any certificates representing unvested Restricted Stock issued such Participant. The deposited certificates shall remain in escrow until all Restrictions lapse or have been removed. The
Participant shall, upon the execution of this Agreement, execute Joint Escrow Instructions in the form attached to this Agreement as Exhibit A. The Joint Escrow Instructions shall be delivered to escrow agent named therein. The Participant
shall deliver to such escrow agent a stock assignment duly endorsed in blank, in the form attached to this Agreement as Exhibit B, and hereby instructs the Company to deliver to such escrow agent, on behalf of the Participant, the
certificate(s) evidencing the Restricted Stock issued hereunder. Such materials shall be held by such escrow agent pursuant to the terms of such Joint Escrow Instructions. 
 4.2 Restricted Stock Not Transferable. Prior to vesting pursuant to Section 3.2 above, no Restricted Stock or any interest or right therein or part thereof shall be liable for the debts,
contracts or engagements of the Participant or his successors in interest or shall be subject to disposition by transfer, alienation, anticipation, pledge, encumbrance, assignment or any other means whether such disposition be voluntary or
involuntary or by operation of law by judgment, levy, attachment, garnishment or any other legal or equitable proceedings (including bankruptcy), and any attempted disposition thereof shall be null and void and of no effect; provided,
however, that this Section 4.2 shall not prevent transfers by will or by applicable laws of descent and distribution. 
 4.3 Rights
as Stockholder. No Participant shall have any rights as a stockholder with respect to any shares of Common Stock to be distributed with respect to an Award until becoming the record holder of such shares. 

4.4 Governing Law. The laws of the Commonwealth of Massachusetts shall govern the interpretation, validity, administration, enforcement and
performance of the terms of this Agreement regardless of the law that might be applied under principles of conflicts of laws. 
 4.5
Conformity to Securities Laws. The Participant acknowledges that the Plan and this Agreement are intended to conform to the extent necessary with all provisions of the Securities Act of 1933, as amended, and the Securities Exchange Act of
1934, as amended (the “Exchange Act”), and any and all regulations and rules promulgated thereunder by the Securities and Exchange Commission, including without limitation Rule 16b-3 under the Exchange Act. Notwithstanding
anything herein to the contrary, the Plan shall be administered, and the Awards are granted, only in such a manner as to conform to such laws, rules and regulations. To the extent permitted by applicable law, the Plan and this Agreement shall
be deemed amended to the extent necessary to conform to such laws, rules and regulations. 
 4.6 Amendment, Suspension and
Termination. The Awards may be wholly or partially amended or otherwise modified, suspended or terminated at any time or from time to time by the Board, provided that, except as may otherwise be provided by the Plan, neither the
amendment, suspension nor termination of this Agreement shall, without the consent of the Participant, alter or impair any rights or obligations under any Award. 
 4.7 Notices. Notices required or permitted hereunder shall be given in writing and shall be deemed effectively given upon personal delivery or upon deposit in the United States mail by
certified mail, with postage and fees prepaid, addressed to the Participant to his address shown in the Company records, and to the Company at its principal executive office. 

  
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 4.8 Severability. The
invalidity or unenforceability of any paragraph or provision of this Agreement shall not affect the validity or enforceability of any other paragraph or provision, and all other provisions shall remain in full force and effect. If any provision
of this Agreement is held to be excessively broad, then such provision shall be reformed and construed by limiting and reducing it so as to be enforceable to the maximum extent permitted by law. 

4.9 No Obligation to Continue Business Relationship. Neither the Plan, this Agreement, nor the grant of this Award imposes any obligation on the
Company to continue to maintain a business relationship with the Participant. 
  

	4.10	Investment Representations. The Participant represents, warrants and covenants as follows: 

(a) The Participant is purchasing the Shares for his own account for investment only, and not with a view to, or for sale in connection
with, any distribution of the Shares in violation of the Securities Act, or any rule or regulation under the Securities Act. 

(b) The Participant has had such opportunity as he has deemed adequate to obtain from representatives of the Company such information as
is necessary to permit him to evaluate the merits and risks of his investment in the Company. 
 (c) The Participant has
sufficient experience in business, financial and investment matters to be able to evaluate the risks involved in the purchase of the Shares and to make an informed investment decision with respect to such purchase. 

(d) The Participant can afford a complete loss of the value of the Shares and is able to bear the economic risk of holding such Shares
for an indefinite period. 
 (e) The Participant understands that (i) the Shares have not been registered under the
Securities Act and are “restricted securities” within the meaning of Rule 144 under the Securities Act; (ii) the Shares cannot be sold, transferred or otherwise disposed of unless they are subsequently registered under the
Securities Act or an exemption from registration is then available; (iii) in any event, the exemption from registration under Rule 144 will not be available for at least one year and even then will not be available unless a public market
then exists for the Common Stock, adequate information concerning the Company is then available to the public, and other terms and conditions of Rule 144 are complied with; and (iv) there is now no registration statement on file with the
Securities and Exchange Commission with respect to any stock of the Company and the Company has no obligation or current intention to register the Shares under the Securities Act. 

  
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 IN WITNESS WHEREOF, this Agreement has
been executed and delivered by the parties hereto. 
  

			
	PAREXEL INTERNATIONAL CORPORATION
		
	By:	 	
 

	Name:	 	Josef H. von Rickenbach
	Title:	 	Chairman & CEO
		
	Signed:	 	  

		 	Director

  

							
	Aggregate number of shares of Restricted Stock	 		 		  	***<@Num @>***
	 subject to the Award:
	 		 		  	                             
     

  
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 Exhibit A 

PAREXEL International Corporation 
 Joint Escrow Instructions 
 <@GrDt @>

 W. Brett Davis 
 Assistant General
Counsel 
 PAREXEL International Corporation 
 200 West Street 
 Waltham, MA 02451 
 Dear Sir: 
 As Escrow Agent for PAREXEL International Corporation, a Massachusetts
corporation, and its successors in interest under the Restricted Stock Agreement (the “Agreement”) of even date herewith, to which a copy of these Joint Escrow Instructions is attached (the “Company”), and the undersigned person
(“Holder”), you are hereby authorized and directed to hold the documents delivered to you pursuant to the terms of the Agreement in accordance with the following instructions: 

 

	 	1.	Appointment. Holder irrevocably authorizes the Company to deposit with you any certificates evidencing Restricted Stock (as defined in the Agreement) to be held
by you hereunder and any additions and substitutions to said Restricted Stock. For purposes of these Joint Escrow Instructions, “Restricted Stock” shall be deemed to include any additional or substitute property. Holder does hereby
irrevocably constitute and appoint you as his attorney-in-fact and agent for the term of this escrow to execute with respect to such Restricted Stock all documents necessary or appropriate to make such Restricted Stock negotiable and to complete any
transaction herein contemplated. Subject to the provisions of this Section 1 and the terms of the Agreement, Holder shall exercise all rights and privileges of a stockholder of the Company while the Restricted Stock is held by you.

  

	 	2.	Closing of Purchase. 

 (a)
Upon the exercise of any forfeiture rights by the Company of the Restricted Stock pursuant to the Agreement, the Company shall give to Holder and you a written notice pursuant to the Agreement. Holder and the Company hereby irrevocably authorize and
direct you to close the transaction contemplated by such notice in accordance with the terms of said notice (the “Closing”). 
 (b) At the Closing, you are directed (i) to date the stock assignment form or forms necessary for the transfer of the Restricted Stock, (ii) to fill in on such form or forms the

  
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number of Restricted Stock being transferred, and (iii) to deliver same, together with the certificate or certificates evidencing the Restricted Stock to be transferred, to the Company.

  

	 	3.	Withdrawal. The Holder shall have the right at any time to withdraw from this escrow any Restricted Stock which is no longer subject to forfeiture.

  

	 	4.	Duties of Escrow Agent. 

(a) Your duties hereunder may be altered, amended, modified or revoked only by a writing signed by all of the parties hereto. 

(b) You shall be obligated only for the performance of such duties as are specifically set forth herein and may rely and shall be
protected in relying or refraining from acting on any instrument reasonably believed by you to be genuine and to have been signed or presented by the proper party or parties. You shall not be personally liable for any act you may do or omit to do
hereunder as Escrow Agent or as attorney-in-fact of Holder while acting in good faith and in the exercise of your own good judgment, and any act done or omitted by you pursuant to the advice of your own attorneys shall be conclusive evidence of such
good faith. 
 (c) You are hereby expressly authorized to disregard any and all warnings given by any of the parties hereto or by
any other person or entity, excepting only orders or process of courts of law, and are hereby expressly authorized to comply with and obey orders, judgments or decrees of any court. If you are uncertain of any actions to be taken or instructions to
be followed, you may refuse to act in the absence of an order, judgment or decrees of a court. In case you obey or comply with any such order, judgment or decree of any court, you shall not be liable to any of the parties hereto or to any other
person or entity, by reason of such compliance, notwithstanding any such order, judgment or decree being subsequently reversed, modified, annulled, set aside, vacated or found to have been entered without jurisdiction. 

(d) You shall not be liable in any respect on account of the identity, authority or rights of the parties executing or delivering or
purporting to execute or deliver the Agreement or any documents or papers deposited or called for hereunder. 
 (e) You shall be
entitled to employ such legal counsel and other experts as you may deem necessary properly to advise you in connection with your obligations hereunder and may rely upon the advice of such counsel. 

(f) Your rights and responsibilities as Escrow Agent hereunder shall terminate if (i) you cease to be an employee of the Company or
(ii) you resign by written notice to each party. In the event of a termination under clause (i), the Secretary of the Company or its designee shall become Escrow Agent hereunder; in the event of a termination under clause (ii), the
Company shall appoint a successor Escrow Agent hereunder. 
 (g) If you reasonably require other or further instruments in
connection with these Joint Escrow Instructions or obligations in respect hereto, the necessary parties hereto shall join in furnishing such instruments. 

  
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 (h) It is understood
and agreed that if you believe a dispute has arisen with respect to the delivery and/or ownership or right of possession of the securities held by you hereunder, you are authorized and directed to retain in your possession without liability to
anyone all or any part of said securities until such dispute shall have been settled either by mutual written agreement of the parties concerned or by a final order, decree or judgment of a court of competent jurisdiction after the time for appeal
has expired and no appeal has been perfected, but you shall be under no duty whatsoever to institute or defend any such proceedings. 
 (i) These Joint Escrow Instructions set forth your sole duties with respect to any and all matters pertinent hereto and no implied duties or obligations shall be read into these Joint Escrow Instructions
against you. 
 (j) The Company shall indemnify you and hold you harmless against any and all damages, losses, liabilities,
costs, and expenses, including attorneys’ fees and disbursements, (including without limitation the fees of counsel retained pursuant to Section 4(e) above, for anything done or omitted to be done by you as Escrow Agent in connection with
this Agreement or the performance of your duties hereunder, except such as shall result from your gross negligence or willful misconduct. 
  

	 	5.	Notice. Any notice required or permitted hereunder shall be given in writing and shall be deemed effectively given upon personal delivery or upon deposit in the
United States Post Office, by registered or certified mail with postage and fees prepaid, addressed to each of the other parties thereunto entitled at the following addresses, or at such other addresses as a party may designate by ten days’
advance written notice to each of the other parties hereto. 

  

							
		 		 	COMPANY:	  	Notices to the Company shall be sent to the address set forth in the salutation hereto, Attn: Chief Financial Officer
				
		 		 	HOLDER:	  	Notices to Holder shall be sent to the address set forth below Holder’s signature below.
				
		 		 	ESCROW AGENT:	  	Notices to the Escrow Agent shall be sent to the address set forth in the salutation hereto.

 

	 	6.	Miscellaneous. 

 (a) By
signing these Joint Escrow Instructions, you become a party hereto only for the purpose of said Joint Escrow Instructions, and you do not become a party to the Agreement. 

  
 9 

  
 (b) This instrument
shall be binding upon and inure to the benefit of the parties hereto and their respective successors and permitted assigns. 
  

			
	Very truly yours,
	
	 PAREXEL International Corporation

		
	 By:
	 	
 

		
	 Title:
	 	 Chairman & CEO

	
	 HOLDER:

			
	
	  

	(Signature)
		
	<@Name	 	@>
	Print Name
		
	 Address:
	 	 
		
		 	 
	
	 Date Signed: <@AcDt @>

 

	
	ESCROW AGENT:
	             Brett
Davis                                        
                    

  
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 Exhibit B 

(STOCK ASSIGNMENT SEPARATE FROM CERTIFICATE)             

FOR VALUE RECEIVED, I hereby sell, assign and transfer unto PAREXEL International Corporation
(                    ) shares of Common Stock, $0.01 par value per share, of PAREXEL International Corporation (the “Corporation”)
standing in my name on the books of the Corporation represented by Certificate(s) Number                      herewith, and do hereby
irrevocably constitute and appoint                      attorney to transfer the said stock on the books of the Corporation with full power of
substitution in the premises. 
  

	
	Dated:                     
	
	  

	Director

  
 11Consulting Letter Agreement - William J. Rieflin

  
 Exhibit 10.43

 August 26, 2010 
 William
J. Rieflin 
  

	Re:	XENOPORT Consulting Contract # 2917 

Ladies and Gentlemen: 
 The purpose of this
Letter Agreement (the “Agreement”) is to set forth the terms of the consultancy with XENOPORT, INC. (“XENOPORT”) by William J. Rieflin (“Consultant”), effective as of August 26, 2010 (the “Effective
Date”), which are as follows: 
 1. Consultant shall act as a consultant to XENOPORT from time to time during the period
from September 17, 2010 to the earlier to occur of: (i) December 31, 2010; (ii) the date Consultant is unable to provide the services stated herein or the provision of such services would create a conflict of interest for
Consultant or XENOPORT; and (iii) the earlier termination of this Agreement in accordance with Section 16 of this Agreement. 
 2. Consultant shall consult in the field of general business and administrative matters, including advice for the following matters as such relate to activities of XENOPORT: (i) strategic planning;
(ii) assisting XENOPORT in matters dealing with the U.S. Food and Drug Administration and comparable regulatory agencies; (iii) assisting XENOPORT in critical partner relationships; (iv) assisting XENOPORT with patent or other
intellectual property matters; and (v) for such other consultation as may be agreed to by the parties from time to time, as such relates to professional services as needed by XENOPORT. The consultancy will be in the form of meetings, advice,
data review, document drafting, editing and review and report preparation and the like, at facilities of XENOPORT or at other mutually convenient locations as shall be agreed to by the parties in advance. 

3. In recognition of these services, XENOPORT agrees to pay Consultant at the rate of $300.00 (US) per full hour of consulting time
(exclusive of travel time), prorated for partial hours, plus reasonable documented out-of-pocket expenses, including transportation and meal expenses pre-approved in writing by XENOPORT, incurred in connection with the consulting services provided
and consistent with XENOPORT’s travel and reimbursement policies. XENOPORT has determined that this amount fairly represents the fair market value for the services to be performed based on the experience and expertise of Consultant.
Consultant shall invoice XENOPORT not more frequently than monthly, referencing Contract # 2917, and such invoices shall be payable 30 days after receipt by XENOPORT. Invoices shall be addressed to XenoPort Accounts Payable or sent to
Accounts.Payable@XenoPort.com. Payments by XENOPORT are subject to appropriate state tax withholding for services performed within the State of California by non-residents of the state. Payment for consulting services rendered hereunder shall
be subject to the completion of such services to the reasonable satisfaction of XENOPORT. 

 William J. Rieflin 

August 26, 2010 
 
Page
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 The parties agree that, notwithstanding that there will be no break in Consultant’s
“Continuous Service” to XENOPORT as described below, effective as of the close of business on September 16, 2010, in connection with the termination of employment with XENOPORT, all vesting of stock options, restricted stock units
(“RSUs”), performance stock units (“PSUs”) or other equity awards granted to Consultant pursuant to the terms and conditions of the XenoPort, Inc. 2005 Equity Incentive Plan (the “2005 Plan”) outstanding on
September 16, 2010, shall immediately cease. 
 The parties further agree that there is no break in Consultant’s continuous service to
XENOPORT between Consultant’s employment with XENOPORT as an employee and then XENOPORT’s retention of (i) Consultant’s services to XENOPORT under this Agreement and (ii) Consultant’s services to XENOPORT as a member of
the XENOPORT board of directors, both effective September 17, 2010. As such, until the period of time ending on the later of (i) the termination of this Agreement and (ii) the termination of Consultant’s services as a member of
the XENOPORT board of directors (such period, the “Continued Period of Service”), Consultant shall be deemed to continue to provide “Continuous Service” to XENOPORT (as defined in the 2005 Plan) with respect to any such stock
options granted to Consultant pursuant to the terms and conditions of the 2005 Plan that are vested and outstanding as of September 16, 2010, and such vested stock options shall remain exercisable during the Continued Period of Service (subject
to the original stated expiration date under the terms of the respective stock option grant agreements). 
 For the purpose of clarity, the
parties further agree that: (i) all outstanding unvested stock options, RSUs, PSUs or other equity awards held by Consultant as of his last day as an employee of XENOPORT (i.e., all unvested equity awards as of September 16, 2010)
and listed on Exhibit A hereto shall immediately cease vesting as of September 16, 2010 (and, in the case of RSUs and PSUs, such unvested equity awards shall then immediately terminate); (ii) all outstanding vested stock options
held by Consultant as of his last day as an employee of XENOPORT (i.e., all vested stock options as of September 16, 2010) and listed on Exhibit A hereto shall continue to be exercisable throughout the term of the Continued Period
of Service (subject to the original stated expiration date under the terms of the respective stock option grant agreements); and (iii) all vested incentive stock options listed on Exhibit A shall automatically convert to nonstatutory
stock options effective December 17, 2010 (if not exercised prior to such date). Upon the termination of the Continued Period of Service and the resulting interruption in Consultant’s Continuous Service to XENOPORT, all such vested stock
options will terminate if not exercised within three (3) months following the termination of the Continued Period of Service and the resulting interruption in Consultant’s Continuous Service to XENOPORT in accordance with the terms and
conditions of the 2005 Plan. 
 4. “Confidential Information” means all information, including, without limitation,
data, trade secrets, know-how, technology, samples and specimens relating to XENOPORT and its products, product concepts, technologies, business, financial, marketing, clinical or regulatory affairs, manufacturing processes and procedures, clinical
and research development programs, or those of any third party from whom XENOPORT receives information on a confidential basis, whether written, graphic or oral, furnished to Consultant by, or on behalf of, XENOPORT, either directly or indirectly,
or obtained or observed by Consultant while providing services hereunder, and the services to be provided by Consultant hereunder, with the exception only of the following: 
 (a) information that is now in the public domain or subsequently enters the public domain without fault on the part of Consultant; 

 William J. Rieflin 

August 26, 2010 
 
Page
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 (b) information
that is presently known by Consultant from Consultant’s own sources as evidenced by Consultant’s prior written records; or 
 (c) information disclosed to Consultant by a third party legally and contractually entitled to make such disclosures. 
 Any combination of features or disclosures shall not be deemed to fall within the foregoing exclusions merely because certain individual features are published or available to the general public or in the
rightful possession of Consultant unless the combination as a whole falls within any of the above exceptions. 
 Except as required in
Consultant’s duties to XENOPORT, Consultant shall not disclose or use at any time or for any purpose, either during or subsequent to the term of this Agreement, any Confidential Information, without the prior written consent of XENOPORT, to be
given or withheld in XENOPORT’s absolute discretion. Consultant shall take all necessary and reasonable precautions to prevent the disclosure of Confidential Information to any unauthorized third parties. In this regard, Consultant shall
disclose Confidential Information only to those of its employees, consultants or agents who are directly concerned with the use and evaluation of such information for the purposes specified in this Agreement and who are bound by obligations of
confidentiality at least as stringent as those set forth herein. Upon disclosing Confidential Information to any such persons, Consultant will advise them of the confidential nature of the information and will instruct them to take all necessary and
reasonable precautions to prevent the unauthorized disclosure thereof. In furtherance of and without in any way limiting the foregoing, Consultant agrees that no public disclosure of Confidential Information shall be made at research seminars,
lectures or professional meetings, or in publications or papers submitted for publication without XENOPORT’s prior written consent, to be given or withheld in XENOPORT’s absolute direction. Consultant further agrees not to publicly
disseminate Confidential Information over the Internet or any similar form of electronic communication without the prior written approval of XENOPORT, to be given or withheld in XENOPORT’s absolute discretion. Notwithstanding the foregoing,
Confidential Information may be disclosed to the extent required by applicable laws or regulations or as ordered by a court or other regulatory body having competent jurisdiction provided that Consultant uses its best efforts to limit the disclosure
and maintain confidentiality to the extent possible and provides reasonable prior written notice to XENOPORT. 
 Consultant acknowledges that
the use or disclosure of Confidential Information without XENOPORT’s express written permission will cause XENOPORT irreparable harm and that any material breach or threatened material breach of this Agreement by Consultant will entitle
XENOPORT to seek injunctive relief and reasonable attorneys’ fees, in addition to any other legal remedies available to it, in any court of competent jurisdiction. 
 5. All inventions, ideas, improvements, discoveries, enhancements, modifications, know-how, data and information of every kind and description conceived, generated, made or reduced to practice, as the
case may be, by Consultant, either alone or jointly with others, which 

 William J. Rieflin 

August 26, 2010 
 
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arise out of, or relate to, this Agreement (the “Inventions”) shall be the sole and exclusive property of XENOPORT; provided, however, that “Inventions” shall not include
“Consultant Property.” For the purposes of this Section 5, “Consultant Property” shall mean inventions, ideas, improvements, discoveries, enhancements, modifications, know-how, processes, technology and other intellectual
properties that do not relate to the composition of matter, formulation or method of using, making or administering any of XENOPORT’s drugs or product candidates and have been independently conceived and/or developed by Consultant without the
use of XenoPort property (other than XENOPORT library services, which the parties acknowledge Consultant may use) or without the benefit of, or access to, any XENOPORT Confidential Information. All Consultant Property is the sole and exclusive
property of Consultant. Consultant shall disclose such Inventions promptly to XENOPORT, assign all of Consultant’s right, title and interest in and to any such Inventions promptly to XENOPORT without royalty or any other consideration and
execute all applications, assignments or other instruments reasonably requested by XENOPORT, in order for XENOPORT to establish XENOPORT’s ownership of such Inventions and to obtain whatever protection for such Inventions, including patent and
copyright rights in any and all countries on such Inventions as XENOPORT shall determine. Consultant further agrees to cooperate fully with XENOPORT in the process of securing and enforcing XENOPORT’s rights to such Inventions, and XENOPORT
shall compensate Consultant for Consultant’s reasonable time devoted to such activities at XENOPORT’s request and reimburse Consultant for reasonable expenses incurred in connection therewith. 

Consultant agrees that if XENOPORT is unable because of Consultant’s unavailability, dissolution, mental or physical incapacity, or for any other
reason, to secure Consultant’s signature to apply for, or to pursue, any application for any United States or foreign patents or mask work or copyright registrations covering the Inventions, then Consultant hereby irrevocably designates and
appoints XENOPORT and its duly authorized officers and agents as Consultant’s agent and attorney-in-fact, to act for and in Consultant’s behalf and stead to execute and file any such applications and to do all other lawfully permitted acts
to further the prosecution and issuance of patents, copyright and mask work registrations thereon with the same legal force and effect as if executed by Consultant. 
 All research, deliverables and reports produced by Consultant, either alone or jointly with others, arising from its performance of the services under this Agreement, or any improvements, modifications or
derivative works thereof, whether produced by Consultant, Consultant’s employees or subcontractors or otherwise, and all proprietary rights thereto, shall belong to XENOPORT immediately upon invention, creation or development as a “work
made for hire.” 
 6. All Confidential Information disclosed by, or on behalf of, XENOPORT to Consultant pursuant to this
Agreement shall be and remain the property of XENOPORT, and all written Confidential Information and copies thereof, including all materials and other paper or electronic documents created or prepared that utilize, are based upon or are derivatives
of Confidential Information, shall be promptly returned or lawfully destroyed upon XENOPORT’s request, provided that Consultant shall be entitled to retain one set of all such information for the sole purpose of monitoring Consultant’s
obligations hereunder. 
 7. Consultant will not, during the term of this Agreement, improperly use or disclose any proprietary
information or trade secrets of any former employer or other person or entity with which Consultant has an agreement or duty to keep in confidence information acquired by Consultant, if any. 

 William J. Rieflin 

August 26, 2010 
 
Page
 5
 
  

  
 8. It is
understood that Consultant shall be serving under this Agreement as an independent contractor and shall not be eligible to participate in any benefits extended by XENOPORT to its employees. 

9. Consultant shall be responsible for obtaining its own benefits, including, but not limited to, worker’s compensation, medical and
disability insurance as applicable, and, upon reasonable request, shall provide XENOPORT with certificates of insurance evidencing any applicable coverages. 
 10. Consultant may not subcontract all or any part of the services to be performed, nor may Consultant assign all or any part of this Agreement, without the prior written consent of XENOPORT, to be given
or withheld in XENOPORT’s absolute discretion. 
 11. Consultant represents and warrants to XENOPORT that Consultant is
legally able to enter into this consulting arrangement with XENOPORT and that this Agreement will not and does not conflict with any applicable ethics policy, agreement, arrangement or understanding, written or oral, to which Consultant is a party
or by which Consultant is bound. 
 12. Consultant represents and warrants to XENOPORT that Consultant has not been debarred or
disqualified by the United States Food and Drug Administration (the “FDA”), nor have debarment or disqualification proceedings against Consultant been commenced. Consultant will immediately notify XENOPORT if any such proceedings have
commenced or if Consultant is debarred or disqualified by the FDA. 
 13. Consultant agrees to provide the services furnished
under this Agreement with due care, in accordance with the standards and practices that are generally accepted in the industry and exercised by other persons engaged in performing similar services and in accordance with all applicable federal and
state laws and regulations. 
 14. Consultant acknowledges that XENOPORT is a public company with securities listed on the
Nasdaq Global Select Market. Consultant is aware of the restrictions imposed by the U.S. securities laws on the purchase or sale of securities by any person who has received material, non-public information from the issuer of such securities and on
the communication of such information to any other person when it is reasonably foreseeable that such other person is likely to purchase or sell such securities in reliance upon such information. Consultant will advise its employees and agents who
receive Confidential Information of such restrictions. 
 15. Consultant acknowledges and agrees that effective as of the close
of business on September 16, 2010, his last day as an employee of XENOPORT, that certain Change of Control Agreement between the parties, dated November 7, 2007 (the “Change of Control Agreement”), shall automatically terminate,
all obligations of the parties pursuant to the Change of Control Agreement shall be deemed to have been satisfied and extinguished and the Change of Control Agreement shall no longer be in effect. 

 William J. Rieflin 

August 26, 2010 
 
Page
 6
 
  

  
 16. Either party
may terminate this Agreement at any time upon 30 days’ written notice to the other party. Sections 3, 4, 5, 6, 12, 15, 16, 17 and 18 of this Agreement shall survive expiration or termination of this Agreement for any reason. In the event of
termination of this Agreement, subject to Section 3, Consultant shall be entitled to compensation for services rendered and reimbursement for non-cancelable expenses incurred under this Agreement prior to the date of termination. For the
purpose of clarity, Section 3 shall survive the termination of this Agreement and remain in effect until the expiration of the Continued Period of Service and the resulting interruption in Consultant’s Continuous Service to XENOPORT such
that all vested stock options will terminate if not exercised within three (3) months following the termination of the Continued Period of Service in accordance with the terms and conditions of the 2005 Plan. 

17. This Agreement shall be governed by, and construed in accordance with, the laws of the State of California, excluding any choice of
law rules that may direct the application of the laws of another jurisdiction. The parties hereby expressly consent to the personal jurisdiction and venue in the state and federal courts for the county in which XENOPORT’s principal place of
business is located for any lawsuit filed there arising from, or related to, this Agreement. 
 18. Miscellaneous:

 (a) If any one or more provisions of this Agreement shall be found to be illegal or unenforceable in any respect, the
validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby, provided the surviving agreement materially comports with the parties’ original intent. The parties shall make a good faith
effort to replace any such provision with a valid and enforceable one such that the objectives contemplated by the parties when entering this Agreement may be realized. 
 (b) Neither party’s failure to exercise, or delay in exercising, any privileges, powers, rights or remedies under this Agreement shall operate as a waiver or estoppel thereof, nor shall any single or
partial exercise of any right or remedy under this Agreement preclude further exercise of any other right or remedy hereunder. The rights and remedies of the parties provided in this Agreement shall not be exclusive and are in addition to any other
rights and remedies at law or in equity. 
 (c) No amendment, change or modification to this Agreement shall be effective unless
in writing and executed by the parties hereto. 
 (d) This Agreement and any subsequent amendment(s), may be executed in
counterparts, and the counterparts, together, shall constitute a single agreement. A facsimile transmission or scanned electronic copy (PDF file) of this signed Agreement bearing a signature on behalf of a party shall be legal and binding on such
party. 
 (e) This Agreement constitutes the entire agreement between the parties relating to the subject matter hereof and
supersedes, as of the Effective Date, all prior negotiations, representations or agreements, either written or oral, with respect to the subject matter hereof. 

 William J. Rieflin 

August 26, 2010 
 
Page
 7
 
  

  
 If the foregoing is acceptable,
please sign both copies of this Agreement and return one fully executed original to XENOPORT. 
  

	
	Very truly yours,
	
	XENOPORT, INC.
	
	 /s/ Ronald W. Barrett

	Ronald W. Barrett, PhD
	Chief Executive Officer
	
	AGREED TO AND ACCEPTED AS OF THE EFFECTIVE DATE.
	
	CONSULTANT:
	
	WILLIAM J. RIEFLIN
	
	 /s/ William J. Rieflin

 

			
	Fed Tax ID or SS #:	 	  

 IMPORTANT NOTICE: IF APPLICABLE TO YOU OR YOUR BUSINESS, XENOPORT MUST HAVE A COMPLETED W-9 FORM ON FILE IN ORDER TO PROCESS ANY INVOICE FOR PAYMENT. UNLESS YOU HAVE PREVIOUSLY PROVIDED A COMPLETED W-9
FORM, OR THE W-9 FORM IS NOT APPLICABLE TO YOUR BUSINESS, YOU MUST COMPLETE THE ATTACHED W-9 FORM AND RETURN IT TO XENOPORT ACCOUNTS PAYABLE ALONG WITH YOUR FIRST INVOICE. WHEN INVOICING, YOU MUST REFER TO CONTRACT # 2917. XENOPORT WILL NOT PROCESS
INVOICES IF A REQUIRED W-9 HAS NOT BEEN PROVIDED, OR IF THEY DO NOT REFERENCE THIS CONTRACT NUMBER. 

  
 Exhibit A

 Equity Awards as of September 16, 2010 

 

																																													
	Name	  	ID	 	  	Grant
Number	 	  	Grant
Date	 	  	Plan/Type	 	  	Shares	 	  	Price	 	  	Exercised/
Released	 	  	Vested	 	  	Unvested*	 	  	Outstanding/
Unreleased	 	  	Exercisable
Releasable**	 
	Rieflin, William J	  	 	100159	  	  	 	10002726	  	  	 	5/13/2010	  	  	 	2005/PSU	  	  	 	40,000	  	  	$	0.0000	  	  	 	0	  	  	 	0	  	  	 	40,000	  	  	 	40,000	  	  	 	0	  
		  				  	 	10002613	  	  	 	3/12/2010	  	  	 	2005/RSU	  	  	 	40,000	  	  	$	0.0000	  	  	 	0	  	  	 	0	  	  	 	40,000	  	  	 	40,000	  	  	 	0	  
		  				  	 	10002058	  	  	 	1/14/2009	  	  	 	2005/RSU	  	  	 	5,592	  	  	$	0.0000	  	  	 	5,592	  	  	 	5,592	  	  	 	0	  	  	 	0	  	  	 	0	  
		  				  	 	10001777	  	  	 	1/30/2008	  	  	 	2005/RSU	  	  	 	5,000	  	  	$	0.0000	  	  	 	2,500	  	  	 	2,500	  	  	 	2,500	  	  	 	2,500	  	  	 	0	  
		  				  	 	10001099	  	  	 	1/30/2007	  	  	 	2005/RSU	  	  	 	5,835	  	  	$	0.0000	  	  	 	5,835	  	  	 	5,835	  	  	 	0	  	  	 	0	  	  	 	0	  
		  				  	 	10000842	  	  	 	9/20/2004	  	  	 	PRES/RSP	  	  	 	33,333	  	  	$	0.0060	  	  	 	33,333	  	  	 	33,333	  	  	 	0	  	  	 	0	  	  	 	0	  
		  				  	 	10000843	  	  	 	9/20/2004	  	  	 	PRES/RSP	  	  	 	116,666	  	  	$	0.0060	  	  	 	116,666	  	  	 	116,666	  	  	 	0	  	  	 	0	  	  	 	0	  
		  				  	 	10000577	  	  	 	9/20/2004	  	  	 	1999/NQ	  	  	 	66,666	  	  	$	2.7000	  	  	 	66,666	  	  	 	66,666	  	  	 	0	  	  	 	0	  	  	 	0	  
		  				  	 	10000582	  	  	 	9/20/2004	  	  	 	1999/NQ	  	  	 	12,963	  	  	$	2.7000	  	  	 	12,963	  	  	 	12,963	  	  	 	0	  	  	 	0	  	  	 	0	  
		  				  	 	10000576	  	  	 	9/20/2004	  	  	 	1999/ISO	  	  	 	37,036	  	  	$	2.7000	  	  	 	37,036	  	  	 	37,036	  	  	 	0	  	  	 	0	  	  	 	0	  
		  				  	 	10000942	  	  	 	1/31/2006	  	  	 	2005/ISO	  	  	 	27,706	  	  	$	15.0000	  	  	 	24,997	  	  	 	27,706	  	  	 	0	  	  	 	2,709	  	  	 	2,709	 *** 
		  				  	 	10000943	  	  	 	1/31/2006	  	  	 	2005/NQ	  	  	 	22,294	  	  	$	15.0000	  	  	 	0	  	  	 	22,294	  	  	 	0	  	  	 	22,294	  	  	 	22,294	  
		  				  	 	10002579	  	  	 	1/13/2010	  	  	 	2005/ISO	  	  	 	4,928	  	  	$	20.0500	  	  	 	0	  	  	 	0	  	  	 	4,928	  	  	 	4,928	  	  	 	0	 *** 
		  				  	 	10002580	  	  	 	1/13/2010	  	  	 	2005/NQ	  	  	 	95,072	  	  	$	20.0500	  	  	 	0	  	  	 	16,666	  	  	 	78,406	  	  	 	95,072	  	  	 	16,666	  
		  				  	 	10001092	  	  	 	1/30/2007	  	  	 	2005/NQ	  	  	 	47,885	  	  	$	23.9600	  	  	 	0	  	  	 	44,683	  	  	 	3,202	  	  	 	47,885	  	  	 	44,683	  
		  				  	 	10001091	  	  	 	1/30/2007	  	  	 	2005/ISO	  	  	 	4,615	  	  	$	23.9600	  	  	 	0	  	  	 	2,347	  	  	 	2,268	  	  	 	4,615	  	  	 	2,347	 *** 
		  				  	 	10002071	  	  	 	1/28/2009	  	  	 	2005/NQ	  	  	 	71 ,599	  	  	$	25.8000	  	  	 	0	  	  	 	31,666	  	  	 	39,933	  	  	 	71,599	  	  	 	31,666	  
		  				  	 	10002070	  	  	 	1/28/2009	  	  	 	2005/ISO	  	  	 	8,401	  	  	$	25.8000	  	  	 	0	  	  	 	0	  	  	 	8,401	  	  	 	8,401	  	  	 	0	 ***
		  				  	 	10001877	  	  	 	1/30/2008	  	  	 	2005/SSR	  	  	 	50,000	  	  	$	59.1700	  	  	 	0	  	  	 	32,291	  	  	 	17,709	  	  	 	50,000	  	  	 	32,291	  
												
		  				  				  	 	TOTALS	  	  				  				  	 	695,591	  	  	 	305,588	  	  	 	458,244	  	  	 	237,347	  	  	 	390,003	  	  	 	152,656	  

  

	*	Unvested shares will be cancelled on 9/16/10 

	**	Shares will be exercisable through continued service period and 90 days after continuous service ceases 

	***	Shares will be converted to NQs on December 17, 2010 if not exercised prior to this date

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