Document:

exv10w1

 

Exhibit 10.1

COMMON STOCK PURCHASE AGREEMENT

by and between

KINGSBRIDGE CAPITAL LIMITED

and

OXiGENE INC.

dated as of February 19, 2008

 

TABLE OF CONTENTS

	 	 	 	 	 	 	 	 	 	 	 
	ARTICLE I	 	DEFINITIONS	 	 	1	 
	 
	 	 	 	 	 	 	 	 	 	 
	ARTICLE II	 	PURCHASE AND SALE OF COMMON STOCK	 	 	5	 
	 

	 	Section 2.1
	 	 	 	Purchase and Sale of Stock
	 	 	5	 
	 

	 	Section 2.2
	 	 	 	Closing
	 	 	5	 
	 

	 	Section 2.3
	 	 	 	Registration Statement and Prospectus
	 	 	6	 
	 

	 	Section 2.4
	 	 	 	Warrant
	 	 	6	 
	 

	 	Section 2.5
	 	 	 	Blackout Shares
	 	 	6	 
	 
	 	 	 	 	 	 	 	 	 	 
	ARTICLE III	 	DRAW DOWN TERMS	 	 	6	 
	 

	 	Section 3.1
	 	 	 	Draw Down Notice
	 	 	6	 
	 

	 	Section 3.2
	 	 	 	Number of Shares
	 	 	6	 
	 

	 	Section 3.3
	 	 	 	Limitation on Draw Downs
	 	 	6	 
	 

	 	Section 3.4
	 	 	 	Trading Cushion
	 	 	6	 
	 

	 	Section 3.5
	 	 	 	Settlement
	 	 	6	 
	 

	 	Section 3.6
	 	 	 	Delivery of Shares; Payment of Draw Down Amount
	 	 	7	 
	 

	 	Section 3.7
	 	 	 	Failure to Deliver Shares
	 	 	7	 
	 
	 	 	 	 	 	 	 	 	 	 
	ARTICLE IV	 	REPRESENTATIONS AND WARRANTIES OF THE COMPANY	 	 	8	 
	 

	 	Section 4.1
	 	 	 	Organization, Good Standing and Power
	 	 	8	 
	 

	 	Section 4.2
	 	 	 	Authorization; Enforcement
	 	 	8	 
	 

	 	Section 4.3
	 	 	 	Capitalization
	 	 	9	 
	 

	 	Section 4.4
	 	 	 	Issuance of Shares
	 	 	9	 
	 

	 	Section 4.5
	 	 	 	No Conflicts
	 	 	10	 
	 

	 	Section 4.6
	 	 	 	Commission Documents, Financial Statements
	 	 	10	 
	 

	 	Section 4.7
	 	 	 	No Material Adverse Change
	 	 	11	 
	 

	 	Section 4.8
	 	 	 	No Undisclosed Liabilities
	 	 	11	 
	 

	 	Section 4.9
	 	 	 	No Undisclosed Events or Circumstances
	 	 	12	 
	 

	 	Section 4.10
	 	 	 	Actions Pending
	 	 	12	 
	 

	 	Section 4.11
	 	 	 	Compliance with Law
	 	 	12	 
	 

	 	Section 4.12
	 	 	 	Certain Fees
	 	 	12	 
	 

	 	Section 4.13
	 	 	 	Disclosure
	 	 	12	 
	 

	 	Section 4.14
	 	 	 	Material Non-Public Information
	 	 	13	 
	 

	 	Section 4.15
	 	 	 	Exemption from Registration; Valid Issuances
	 	 	13	 
	 

	 	Section 4.16
	 	 	 	No General Solicitation or Advertising in Regard to this Transaction
	 	 	13	 
	 

	 	Section 4.17
	 	 	 	No Integrated Offering
	 	 	13	 
	 

	 	Section 4.18
	 	 	 	Acknowledgment Regarding Investor’s Purchase of Shares
	 	 	13	 
	 
	 	 	 	 	 	 	 	 	 	 
	ARTICLE V	 	REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE INVESTOR	 	 	14	 
	 

	 	Section 5.1
	 	 	 	Organization and Standing of the Investor
	 	 	14	 

i

 

	 	 	 	 	 	 	 	 	 	 	 
	 

	 	Section 5.2
	 	 	 	Authorization and Power
	 	 	14	 
	 

	 	Section 5.3
	 	 	 	No Conflicts
	 	 	14	 
	 

	 	Section 5.4
	 	 	 	Financial Capability
	 	 	15	 
	 

	 	Section 5.5
	 	 	 	Information
	 	 	15	 
	 

	 	Section 5.6
	 	 	 	Trading Restrictions
	 	 	15	 
	 

	 	Section 5.7
	 	 	 	Statutory Underwriter Status
	 	 	15	 
	 

	 	Section 5.8
	 	 	 	Not an Affiliate
	 	 	15	 
	 

	 	Section 5.9
	 	 	 	Manner of Sale
	 	 	15	 
	 

	 	Section 5.10
	 	 	 	Prospectus Delivery
	 	 	15	 
	 
	 	 	 	 	 	 	 	 	 	 
	ARTICLE VI	 	COVENANTS OF THE COMPANY	 	 	16	 
	 

	 	Section 6.1
	 	 	 	Securities
	 	 	16	 
	 

	 	Section 6.2
	 	 	 	Reservation of Common Stock
	 	 	16	 
	 

	 	Section 6.3
	 	 	 	Registration and Listing
	 	 	16	 
	 

	 	Section 6.4
	 	 	 	Registration Statement
	 	 	17	 
	 

	 	Section 6.5
	 	 	 	Compliance with Laws
	 	 	17	 
	 

	 	Section 6.6
	 	 	 	Other Financing
	 	 	17	 
	 

	 	Section 6.7
	 	 	 	Prohibited Transactions
	 	 	18	 
	 

	 	Section 6.8
	 	 	 	Corporate Existence
	 	 	18	 
	 

	 	Section 6.9
	 	 	 	Non-Disclosure of Non-Public Information
	 	 	18	 
	 

	 	Section 6.10
	 	 	 	Notice of Certain Events Affecting Registration; Suspension of Right to Request a Draw Down
	 	 	18	 
	 

	 	Section 6.11
	 	 	 	Amendments to the Registration Statement
	 	 	19	 
	 

	 	Section 6.12
	 	 	 	Prospectus Delivery
	 	 	19	 
	 
	 	 	 	 	 	 	 	 	 	 
	ARTICLE VII	 	CONDITIONS TO THE OBLIGATION OF THE INVESTOR TO ACCEPT A DRAW DOWN	 	 	19	 
	 

	 	Section 7.1
	 	 	 	Accuracy of the Company’s Representations and Warranties
	 	 	20	 
	 

	 	Section 7.2
	 	 	 	Performance by the Company
	 	 	20	 
	 

	 	Section 7.3
	 	 	 	Compliance with Law
	 	 	20	 
	 

	 	Section 7.4
	 	 	 	Effective Registration Statement
	 	 	20	 
	 

	 	Section 7.5
	 	 	 	No Knowledge
	 	 	20	 
	 

	 	Section 7.6
	 	 	 	No Suspension
	 	 	20	 
	 

	 	Section 7.7
	 	 	 	No Injunction
	 	 	20	 
	 

	 	Section 7.8
	 	 	 	No Proceedings or Litigation
	 	 	20	 
	 

	 	Section 7.9
	 	 	 	Sufficient Shares Registered for Resale
	 	 	21	 
	 

	 	Section 7.10
	 	 	 	Warrant
	 	 	21	 
	 

	 	Section 7.11
	 	 	 	Opinion of Counsel
	 	 	21	 
	 

	 	Section 7.12
	 	 	 	Accuracy of Investor’s Representation and Warranties
	 	 	21	 
	 
	 	 	 	 	 	 	 	 	 	 
	ARTICLE VIII	 	TERMINATION	 	 	21	 
	 

	 	Section 8.1
	 	 	 	Term
	 	 	21	 
	 

	 	Section 8.2
	 	 	 	Other Termination
	 	 	21	 
	 

	 	Section 8.3
	 	 	 	Effect of Termination
	 	 	22	 
	 
	 	 	 	 	 	 	 	 	 	 
	ARTICLE IX	 	INDEMNIFICATION	 	 	22	 
	 

	 	Section 9.1
	 	 	 	Indemnification
	 	 	22	 

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	 	Section 9.2
	 	 	 	Notification of Claims for Indemnification
	 	 	23	 
	 
	 	 	 	 	 	 	 	 	 	 
	ARTICLE X	 	MISCELLANEOUS	 	 	25	 
	 

	 	Section 10.1
	 	 	 	Fees and Expenses
	 	 	25	 
	 

	 	Section 10.2
	 	 	 	Reporting Entity for the Common Stock
	 	 	25	 
	 

	 	Section 10.3
	 	 	 	Brokerage
	 	 	25	 
	 

	 	Section 10.4
	 	 	 	Notices
	 	 	26	 
	 

	 	Section 10.5
	 	 	 	Assignment
	 	 	27	 
	 

	 	Section 10.6
	 	 	 	Amendment; No Waiver
	 	 	27	 
	 

	 	Section 10.7
	 	 	 	Entire Agreement
	 	 	27	 
	 

	 	Section 10.8
	 	 	 	Severability
	 	 	27	 
	 

	 	Section 10.9
	 	 	 	Title and Subtitles
	 	 	28	 
	 

	 	Section 10.10
	 	 	 	Counterparts
	 	 	28	 
	 

	 	Section 10.11
	 	 	 	Choice of Law
	 	 	28	 
	 

	 	Section 10.12
	 	 	 	Specific Enforcement, Consent to Jurisdiction
	 	 	28	 
	 

	 	Section 10.13
	 	 	 	Survival
	 	 	29	 
	 

	 	Section 10.14
	 	 	 	Publicity
	 	 	29	 
	 

	 	Section 10.15
	 	 	 	Further Assurances
	 	 	29	 

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     This COMMON STOCK PURCHASE AGREEMENT (this “Agreement”) is entered into as of the 19th
day of February, 2008, by and between Kingsbridge Capital Limited, an entity organized and existing
under the laws of the British Virgin Islands, whose registered address is Palm Grove House, 2nd
Floor, Road Town, Tortola, British Virgin Islands (the “Investor”) and OXiGENE, Inc. , a
corporation organized and existing under the laws of the State of Delaware (the “Company”).

     WHEREAS, the parties desire that, upon the terms and subject to the conditions and limitations
set forth herein, the Company may issue and sell to the Investor, from time to time as provided
herein, and the Investor shall purchase from the Company, up to $40 million worth of shares of
Common Stock (as defined below); and

     WHEREAS, such investments will be made in reliance upon the provisions of Section 4(2)
(“Section 4(2)”) and Regulation D (“Regulation D”) of the United States Securities
Act of 1933, as amended, and the rules and regulations promulgated thereunder (the “Securities
Act”), and/or upon such other exemption from the registration requirements of the Securities
Act as may be available with respect to any or all of the investments in Common Stock to be made
hereunder; and

     WHEREAS, the parties hereto are concurrently entering into a Registration Rights Agreement in
the form of Exhibit A hereto (the “Registration Rights Agreement”) pursuant to
which the Company shall register the Common Stock issued and sold to the Investor under this
Agreement and issuable under the Warrant (as defined below), upon the terms and subject to the
conditions set forth therein; and

     WHEREAS, in consideration for the Investor’s execution and delivery of, and its performance of
its obligations under, this Agreement, the Company is concurrently issuing to the Investor a
Warrant in the form of Exhibit B hereto (the “Warrant”) pursuant to which the
Investor may purchase from the Company up to 250,000 shares of Common Stock, upon the terms and
subject to the conditions set forth therein;

     NOW, THEREFORE, the parties hereto agree as follows:

ARTICLE I

DEFINITIONS

     As used in this Agreement, the following terms shall have the meanings set forth below:

     “Alternative Draw Down Amount” means the product of (i) Average Trading Volume, (ii)
the Closing Price on the Trading Day preceding the issuance of the Draw Down Notice, (iii) the
number of Trading Days during the Draw Down Pricing Period, and (iv) the Liquidity Ratio.

     “Average Trading Volume” means the average trading volume of the twenty (20) Trading
Days during the thirty (30) Trading Days prior to the issuance of the Draw Down Notice that results
from excluding the five (5) highest and five (5) lowest Trading Days during such period.

     “Blackout Amount” shall have the meaning assigned to such term in the Registration
Rights Agreement.

 

 

     “Blackout Shares” shall have the meaning assigned to such term in the Registration
Rights Agreement.

     “Bylaws” shall have the meaning ascribed to such term in Section 4.3 hereof.

     “Certificate” shall have the meaning assigned to such term in Section 4.3 hereof.

     “Closing Date” shall have the meaning assigned to such term in Section 2.2 hereof.

     “Closing Price” as of any particular day shall mean the closing price per share of the
Company’s Common Stock as reported by Bloomberg L.P. on such day.

     “Commission” means the United States Securities and Exchange Commission.

     “Commission Documents” shall have the meaning assigned to such term in Section 4.6
hereof.

     “Commitment Period” means the period commencing on the Effective Date and expiring on
the earliest to occur of (i) the date on which the Investor shall have purchased Shares pursuant to
this Agreement for an aggregate purchase price equal to the Maximum Commitment Amount, (ii) the
date this Agreement is terminated pursuant to Article VIII hereof, and (iii) the date occurring
thirty-six (36) months from the Effective Date.

     “Common Stock” means the common stock of the Company, par value $0.01 per share.

     “Condition Satisfaction Date” shall have the meaning assigned to such term in Article
VII hereof.

     “Damages” means any loss, claim, damage, liability, costs and expenses (including,
without limitation, reasonable attorneys’ fees and expenses and costs and reasonable expenses of
expert witnesses and investigation).

     “Draw Down” shall have the meaning assigned to such term in Section 3.1 hereof.

     “Draw Down Amount” means the actual dollar amount of a Draw Down paid to the Company.

     “Draw Down Discount Price” means (i) 88% of the VWAP on any Trading Day during a Draw
Down Pricing Period when the VWAP equals or exceeds $1.25 but is less than or equal to $2.40, (ii)
90% of the VWAP on any Trading Day during the Draw Down Pricing Period when VWAP exceeds $2.40 but
is less than or equal to $5.50, (iii) 92% of the VWAP on any Trading Day during the Draw Down
Pricing Period when VWAP exceeds $5.50 but is less than or equal to $9.00, (iv) 94% of the VWAP on
any Trading Day during the Draw Down Pricing Period when VWAP exceeds $9.00 but is less than or
equal to $12.00, or (v) 95% of the VWAP on any Trading Day during the Draw Down Pricing Period when
VWAP exceeds $12.00.

     “Draw Down Notice” shall have the meaning assigned to such term in Section 3.1 hereof.

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     “Draw Down Pricing Period” shall mean, with respect to each Draw Down, a period of
eight (8) consecutive Trading Days beginning on the first Trading Day specified in a Draw Down
Notice.

     “DTC” shall mean the Depository Trust Company, or any successor thereto.

     “Effective Date” means the first Trading Day immediately following the date on which
the Registration Statement is declared effective by the Commission.

     “Exchange Act” means the United States Securities Exchange Act of 1934, as amended,
and the rules and regulations promulgated thereunder.

     “Excluded Merger or Sale” shall have the meaning assigned to such term in the Warrant.

     “FINRA” means the Financial Industry Regulatory Authority.

     “Knowledge” means the actual knowledge of those officers of the Company required to
file statements relating to their ownership of the Company’s securities pursuant to Section 16 of
the Exchange Act.

     “Liquidity Ratio” means fifty percent (50%).

     “Make Whole Amount” shall have the meaning specified in Section 3.7.

     “Market Capitalization” means, as of any Trading Day, the product of (i) the closing
sale price of the Company’s Common Stock as reported by Bloomberg L.P. using the AQR function and
(ii) the number of outstanding shares of Common Stock of the Company as reported by Bloomberg L.P.
using the DES function.

     “Material Adverse Effect” means any effect that is not negated, corrected, cured or
otherwise remedied within a reasonable period of time on the business, operations, properties or
financial condition of the Company and its consolidated subsidiaries that is material and adverse
to the Company and such subsidiaries, taken as a whole, and/or any condition, circumstance, or
situation that would prohibit or otherwise interfere with the ability of the Company to perform any
of its obligations under this Agreement, the Registration Rights Agreement or the Warrant in any
material respect; provided, however, that none of the following shall constitute a “Material
Adverse Effect”: (i) the effects of conditions or events that are generally applicable to the
capital, financial, banking or currency markets or the biotechnology or pharmaceutical industries;
(ii) the effects of conditions or events that are reasonably expected to occur in the Company’s
ordinary course of business (such as, by way of example only, failed clinical trials, serious
adverse events involving the Company’s product candidates, delays in product development,
unfavorable regulatory determinations, difficulties involving collaborators or intellectual
property disputes), except for purposes of Section 4.9 herein; (iii) any changes or effects
resulting from the announcement or consummation of the transactions contemplated by this Agreement,
including, without limitation, any changes or effects associated with any particular Draw Down, and
(iv) changes in the market price of the Common Stock.

-3-

 

     “Maximum Commitment Amount” means the lesser of (i) $40 million in aggregate Draw Down
Amounts or (ii) such number of shares of Common Stock (as adjusted for stock splits, stock
combinations, stock dividends and recapitalizations that occur on or after the date of this
Agreement) that the Company may issue pursuant to this Agreement and the transactions contemplated
hereby without violating the rules and regulations of the Principal Market.

     “Maximum Draw Down Amount” means the lesser of $10 million or either (i) 2.0% of the
Company’s Market Capitalization at the time of the Draw Down, or (ii) the lesser of (A) 3.5% of the
Company’s Market Capitalization at the time of the Draw Down, and (B) the Alternative Draw Down
Amount.

     “Permitted Transaction” shall have the meaning assigned to such term in Section 6.6
hereof.

     “Person” means any individual, corporation, partnership, limited liability company,
association, trust or other entity or organization, including any government or political
subdivision or an agency or instrumentality thereof.

     “Principal Market” means the NASDAQ Global Select Market, the NASDAQ Global Market,
the NASDAQ Capital Market, the American Stock Exchange or the New York Stock Exchange, whichever is
at the time the principal trading exchange or market for the Common Stock.

     “Prohibited Transaction” shall have the meaning assigned to such term in Section 6.7
hereof.

     “Prospectus” as used in this Agreement means the prospectus in the form included in
the Registration Statement, as supplemented from time to time pursuant to Rule 424(b) of the
Securities Act.

     “Registrable Securities” means (i) the Shares, (ii) the Warrant Shares, and (iii) any
securities issued or issuable with respect to any of the foregoing by way of exchange, stock
dividend or stock split or in connection with a combination of shares, recapitalization, merger,
consolidation or other reorganization or otherwise. As to any particular Registrable Securities,
once issued such securities shall cease to be Registrable Securities when (w) the Registration
Statement has been declared effective by the Commission and such Registrable Securities have been
disposed of pursuant to the Registration Statement, (x) such Registrable Securities have been sold
under circumstances under which all of the applicable conditions of Rule 144 (or any similar
provision then in force) under the Securities Act (“Rule 144”) are met, (y) such time as
such Registrable Securities have been otherwise transferred to holders who may trade such shares
without restriction under the Securities Act, and the Company has delivered a new certificate or
other evidence of ownership for such securities not bearing a restrictive legend or (z) in the
opinion of counsel to the Company such Registrable Securities may be sold without registration and
without any time, volume or manner limitations pursuant to Rule 144(b)(1)(i) (or any similar
provision then in effect) under the Securities Act.

     “Registration Rights Agreement” shall have the meaning set forth in the recitals of
this Agreement.

-4-

 

     “Registration Statement” shall have the meaning assigned to such term in the
Registration Rights Agreement.

     “Regulation D” shall have the meaning set forth in the recitals of this Agreement.
“Section 4(2)” shall have the meaning set forth in the recitals of this Agreement.

     “Securities Act” shall have the meaning set forth in the recitals of this Agreement.

     “Settlement Date” shall have the meaning assigned to such term in Section 3.5 hereof.

     “Shares” means the shares of Common Stock of the Company that are and/or may be
purchased hereunder.

     “Trading Day” means any day other than a Saturday or a Sunday on which the Principal
Market is open for trading in equity securities.

     “VWAP” means the volume weighted average price (the aggregate sales price of all
trades of Common Stock during each Trading Day divided by the total number of shares of Common
Stock traded during such Trading Day) of the Common Stock during any Trading Day as reported by
Bloomberg, L.P. using the AQR function.

     “Warrant” shall have the meaning set forth in the recitals of this Agreement.

     “Warrant Shares” means the shares of Common Stock issuable to the Investor upon
exercise of the Warrant.

ARTICLE II

PURCHASE AND SALE OF COMMON STOCK

     Section 2.1 Purchase and Sale of Stock. Upon the terms and subject to the conditions
set forth in this Agreement, the Company shall to the extent it elects to make Draw Downs in
accordance with Article III hereof, issue and sell to the Investor and the Investor shall purchase
Common Stock from the Company for an aggregate (in Draw Down Amounts) of up to the Maximum
Commitment Amount, consisting of purchases based on Draw Downs in accordance with Article III
hereof.

     Section 2.2 Closing. In consideration of and in express reliance upon the
representations, warranties, covenants, terms and conditions of this Agreement, the Company agrees
to issue and sell to the Investor, and the Investor agrees to purchase from the Company, that
number of the Shares to be issued in connection with each Draw Down. The execution and delivery of
this Agreement (the “Closing”) shall take place at the offices of Stroock & Stroock & Lavan
LLP, 180 Maiden Lane, New York, NY 10038 at 5:00 p.m. local time on February 19, 2008, or at such
other time and place or on such date as the Investor and the Company may agree upon (the
“Closing Date”). Each party shall deliver at or prior to the Closing all documents,
instruments and writings required to be delivered at the Closing by such party pursuant to this
Agreement.

-5-

 

     Section 2.3 Registration Statement and Prospectus. The Company shall prepare and file
with the Commission the Registration Statement (including the Prospectus) in accordance with the
provisions of the Securities Act and the Registration Rights Agreement.

     Section 2.4 Warrant. On the Closing Date, the Company shall issue and deliver the
Warrant to the Investor.

     Section 2.5 Blackout Shares. The Company shall deliver any Blackout Amount or issue
and deliver any Blackout Shares to the Investor in accordance with Section 1.1(e) of the
Registration Rights Agreement.

ARTICLE III

DRAW DOWN TERMS

     Subject to the satisfaction of the conditions hereinafter set forth in this Agreement, the
parties agree as follows:

     Section 3.1 Draw Down Notice. During the Commitment Period, the Company may, in its
sole discretion, issue a Draw Down Notice (as hereinafter defined) which shall specify the dollar
amount of Shares the Company elects to sell to the Investor (each such election, a “Draw
Down”) up to a Draw Down Amount equal to the Maximum Draw Down Amount, which Draw Down the
Investor shall be obligated to accept. The Company shall inform the Investor in writing by sending
a duly completed Draw Down Notice in the form of Exhibit C hereto by e-mail to the
addresses set forth in Section 10.4, with a copy to the Investor’s counsel, as to such Draw Down
Amount before commencement of trading on the first Trading Day of the related Draw Down Pricing
Period (the “Draw Down Notice”). In addition to the Draw Down Amount, each Draw Down
Notice shall designate the first Trading Day of the Draw Down Pricing Period. In no event shall
any Draw Down Amount exceed the Maximum Draw Down Amount. Each Draw Down Notice shall be
accompanied by a certificate, signed by the Chief Executive Officer or Chief Financial Officer,
dated as of the date of such Draw Down Notice, in the form of Exhibit D hereof.

     Section 3.2 Number of Shares. Subject to Section 3.6(b), the number of Shares to be
issued in connection with each Draw Down shall be equal to the sum of the number of shares issuable
on each Trading Day of the Draw Down Pricing Period. The number of shares issuable on a Trading
Day during a Draw Down Pricing Period shall be equal to the quotient of one eighth (1/8th) of the
Draw Down Amount divided by the Draw Down Discount Price for such Trading Day.

     Section 3.3 Limitation on Draw Downs. Only one Draw Down shall be permitted for each
Draw Down Pricing Period.

     Section 3.4 Trading Cushion. Unless the parties agree in writing otherwise, there
shall be a minimum of three (3) Trading Days between the expiration of any Draw Down Pricing Period
and the beginning of the next succeeding Draw Down Pricing Period.

     Section 3.5 Settlement. The number of Shares purchased by the Investor in any Draw
Down shall be determined and settled on two separate dates. Shares purchased by the Investor

-6-

 

during the first four Trading Days of any Draw Down Pricing Period shall be determined and
settled no later than the sixth Trading Day of such Draw Down Pricing Period. Shares purchased by
the Investor during the second four Trading Days of any Draw Down Pricing Period shall be
determined and settled no later than the second Trading Day after the last Trading Day of such Draw
Down Pricing Period. Each date on which settlement of the purchase and sale of Shares occurs
hereunder being referred to as a “Settlement Date.” The Investor shall provide the Company
with delivery instructions for the Shares to be issued at each Settlement Date at least two Trading
Days in advance of such Settlement Date. The number of Shares actually issued shall be rounded
down to the nearest whole number of Shares.

     Section 3.6 Delivery of Shares; Payment of Draw Down Amount.

          (a) On each Settlement Date, the Company shall deliver the Shares purchased by the Investor to
the Investor or its designees exclusively via book-entry through the DTC to an account designated
by the Investor, and upon receipt of the Shares, the Investor shall cause payment thereof to be
made to the Company’s designated account by wire transfer of immediately available funds, if the
Shares are received by the Investor no later than 1:00 p.m. (Eastern Time), or next day available
funds, if the Shares are received thereafter.

          (b) For each Trading Day during a Draw Down Pricing Period where the VWAP is less than the
greater of (i) 85% of the Closing Price of the Company’s Common Stock on the Trading Day
immediately preceding the commencement of such Draw Down Pricing Period, or (ii) $1.25, such
Trading Day shall not be used in calculating the number of Shares to be issued in connection with
such Draw Down, and the Draw Down Amount in respect of such Draw Down Pricing Period shall be
reduced by one eighth (1/8th) of the initial Draw Down Amount specified in the Draw Down Notice.
If trading in the Company’s Common Stock is suspended for any reason for more than three (3)
consecutive or non-consecutive hours during any Trading Day during a Draw Down Pricing Period, such
Trading Day shall not be used in calculating the number of Shares to be issued in connection with
such Draw Down, and the Draw Down Amount in respect of such Draw Down Pricing Period shall be
reduced by one eighth (1/8th) of the initial Draw Down Amount specified in the Draw Down Notice.

     Section 3.7 Failure to Deliver Shares. If on any Settlement Date, the Company fails
to cause the delivery of the Shares purchased by the Investor, and such failure is not cured within
two (2) Trading Days following such Settlement Date, the Company shall pay to the Investor on
demand in cash by wire transfer of immediately available funds to an account designated by the
Investor the “Make Whole Amount;” provided, however, that in the event that the Company is
prevented from delivering Shares in respect of any such Settlement Date in a timely manner by any
fact or circumstance that is not reasonably within the control of, or directly attributable to, the
Company, or is otherwise reasonably within the control of, or directly attributable to, the
Investor, then such two (2) Trading Day period shall be automatically extended until such time as
such fact or circumstance is cured. As used herein, the Make Whole Amount shall be an amount equal
to the sum of (i) the Draw Down Amount actually paid by the Investor in respect of such Shares plus
(ii) an amount equal to the actual loss suffered by the Investor in respect of sales to subsequent
purchasers, pursuant to transactions entered into before the Settlement Date, of the Shares that
were required to be delivered by the Company, which shall be based upon documentation reasonably
satisfactory to the Company demonstrating the difference (if greater

-7-

 

than zero) between (A) the price per share paid by the Investor to purchase such number of
shares of Common Stock necessary for the Investor to meet its share delivery obligations to such
subsequent purchasers minus (B) the average Draw Down Discount Price during the applicable Draw
Down Pricing Period. In the event that the Make Whole Amount is not paid within two (2) Trading
Days following a demand therefor from the Investor, the Make Whole Amount shall accrue interest
compounded daily at a rate equal to ten percent (10%) per annum up to and including the date on
which the Make Whole Amount is actually paid. For the purposes of this Section 3.7 facts or
circumstances that are reasonably within the control of the Company include such facts and
circumstances attributable to acts or omissions of the Company, its officers, directors, employees,
agents and representatives, including, without limitation, any transfer agent(s), accountant(s)
and/or attorney(s) engaged by the Company in connection with the Company’s performance of its
obligations hereunder. Notwithstanding anything to the contrary set forth in this Agreement, in
the event that the Company pays the Make Whole Amount (plus interest, if applicable) in respect of
any Settlement Date in accordance with this Section 3.7, such payment shall be the Investor’s sole
remedy in respect of the Company’s failure to deliver Shares in respect of such Settlement Date,
and the Company shall not be obligated to deliver such Shares.

ARTICLE IV

REPRESENTATIONS AND WARRANTIES OF THE COMPANY

     The Company hereby makes the following representations and warranties to the Investor:

     Section 4.1 Organization, Good Standing and Power. The Company is a corporation duly
organized, validly existing and in good standing under the laws of the State of Delaware and has
all requisite power and authority to own, lease and operate its properties and assets and to carry
on its business as now being conducted. Except as set forth in the Commission Documents (as
defined below), the Company does not own more than fifty percent (50%) of the outstanding capital
stock of or control any other business entity, other than any wholly-owned subsidiary that is not
“significant” within the meaning of Regulation S-X promulgated by the Commission. The
Company is duly qualified as a foreign corporation to do business and is in good standing in every
jurisdiction in which the nature of the business conducted or property owned by it makes such
qualification necessary, other than those in which the failure to be so qualified or be in good
standing would not have a Material Adverse Effect.

     Section 4.2 Authorization; Enforcement. (i) The Company has the requisite corporate
power and authority to enter into and perform its obligations under this Agreement, the
Registration Rights Agreement and the Warrant and to issue the Shares, the Warrant, the Warrant
Shares and any Blackout Shares (except to the extent that the number of Blackout Shares required to
be issued exceeds the number of authorized shares of Common Stock under the Certificate); (ii) the
execution and delivery of this Agreement and the Registration Rights Agreement, and the execution,
issuance and delivery of the Warrant, by the Company and the consummation by it of the transactions
contemplated hereby and thereby have been duly and validly authorized by all necessary corporate
action and no further consent or authorization of the Company or its Board of Directors or
stockholders is required (other than as contemplated by Section 6.5); and (iii) each of this
Agreement and the Registration Rights Agreement has been duly executed and delivered, and the
Warrant has been duly executed, issued and delivered, by

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the Company and constitutes a valid and binding obligation of the Company enforceable against
the Company in accordance with its terms, except as rights under indemnity and contribution
thereunder may be limited by federal or state securities laws and except as such enforceability may
be limited by applicable bankruptcy, securities, insolvency, or similar laws relating to, or
affecting generally the enforcement of, creditors’ rights and remedies, or indemnification or by
other equitable principles of general application.

     Section 4.3 Capitalization. The authorized capital stock of the Company and the
shares thereof issued and outstanding as of September 30, 2007 are set forth on a schedule (the
“Disclosure Schedule”) previously delivered to the Investor. All of the outstanding shares
of the Common Stock have been duly and validly authorized and issued, and are fully paid and
non-assessable. Except as set forth in this Agreement or as previously disclosed on the Disclosure
Schedule, as of September 30, 2007, no shares of Common Stock were entitled to preemptive rights or
registration rights and there were no outstanding options, warrants, scrip, rights to subscribe to,
call or commitments of any character whatsoever relating to, or securities or rights convertible
into or exchangeable for or giving any right to subscribe for, any shares of capital stock of the
Company, except for stock options issued by the Company to its employees, directors and
consultants. Except as set forth in this Agreement, the Commission Documents, or as previously
disclosed to the Investor in the Disclosure Schedule, as of September 30, 2007, there were no
contracts, commitments, understandings, or arrangements by which the Company is or may become bound
to issue additional shares of the capital stock of the Company or options, securities or rights
convertible into or exchangeable for or giving any right to subscribe for any shares of capital
stock of the Company. Except as described in the Commission Documents or as previously disclosed
to the Investor in the Disclosure Schedule, as of the date hereof the Company is not a party to any
agreement granting registration rights to any Person with respect to any of its equity or debt
securities. Except as set forth in the Commission Documents or as previously disclosed to the
Investor in writing, as of the date hereof the Company is not a party to, and it has no Knowledge
of, any agreement restricting the voting or transfer of any shares of the capital stock of the
Company. The offer and sale of all capital stock, convertible securities, rights, warrants, or
options of the Company issued during the twenty-four month period immediately prior to the Closing
complied in all material respects with all applicable federal and state securities laws, and no
stockholder has a right of rescission or damages with respect thereto that could reasonably be
expected to have a Material Adverse Effect. The Company has furnished or made available to the
Investor true and correct copies of the Company’s Restated Certificate of Incorporation, as amended
and in effect on the date hereof (the “Certificate”), and the Company’s Amended and
Restated By-Laws, as amended and in effect on the date hereof (the “Bylaws”).

     Section 4.4 Issuance of Shares. Subject to Section 6.5, the Shares, the Warrant and
the Warrant Shares have been, and any Blackout Shares will be, duly authorized by all necessary
corporate action (except to the extent that the number of Blackout Shares required to be issued
exceeds the number of authorized shares of Common Stock under the Certificate) and, when issued and
paid for in accordance with the terms of this Agreement, the Registration Rights Agreement and the
Warrant, and subject to, and in reliance on, the representations, warranties and covenants made
herein by the Investor, the Shares and the Warrant Shares shall be validly issued and outstanding,
fully paid and non-assessable, and the Investor shall be entitled to all rights accorded to a
holder of shares of Common Stock.

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     Section 4.5 No Conflicts. The execution, delivery and performance of this Agreement,
the Registration Rights Agreement, the Warrant and any other document or instrument contemplated
hereby or thereby, by the Company and the consummation by the Company of the transactions
contemplated hereby and thereby do not and shall not in any material respect: (i) result in the
violation of any provision of the Certificate or Bylaws, (ii) conflict with, or constitute a
default (or an event which with notice or lapse of time or both would become a default) under, or
give rise to any rights of termination, amendment, acceleration or cancellation of, any material
agreement, mortgage, deed of trust, indenture, note, bond, license, lease agreement, instrument or
obligation to which the Company is a party where such default or conflict would constitute a
Material Adverse Effect, (iii) create or impose a lien, charge or encumbrance on any property of
the Company under any agreement or any commitment to which the Company is a party or by which the
Company is bound or by which any of its respective properties or assets are bound which would
constitute a Material Adverse Effect, (iv) result in a violation of any federal, state, local or
foreign statute, rule, regulation, order, writ, judgment or decree (including federal and state
securities laws and regulations) applicable to the Company or any of its subsidiaries or by which
any property or asset of the Company or any of its subsidiaries are bound or affected where such
violation would constitute a Material Adverse Effect, or (v) require any consent of any third-party
that has not been obtained pursuant to any material contract to which the Company is subject or to
which any of its assets, operations or management may be subject where the failure to obtain any
such consent would constitute a Material Adverse Effect. The Company is not required under
federal, state or local law, rule or regulation to obtain any consent, authorization or order of,
or make any filing or registration with, any court or governmental agency in order for it to
execute, deliver or perform any of its obligations under this Agreement, the Registration Rights
Agreement or the Warrant, or issue and sell the Shares, the Warrant Shares or the Blackout Shares
(except to the extent that the number of Blackout Shares required to be issued exceeds the number
of authorized shares of Common Stock under the Certificate) in accordance with the terms hereof and
thereof (other than any filings that may be required to be made by the Company with the Commission,
the FINRA/NASDAQ or state securities commissions subsequent to the Closing, and, any registration
statement (including any amendment or supplement thereto) or any other filing or consent which may
be filed pursuant to this Agreement, the Registration Rights Agreement or the Warrant); provided
that, for purposes of the representation made in this sentence, the Company is assuming and relying
upon the accuracy of the relevant representations and agreements of the Investor herein.

     Section 4.6 Commission Documents, Financial Statements.

          (a) The Common Stock is registered pursuant to Section 12(b) or 12(g) of the Exchange Act, and
since January 1, 2007 the Company has timely filed all reports, schedules, forms, statements and
other documents required to be filed by it with the Commission pursuant to the reporting
requirements of the Exchange Act, including material filed pursuant to Section 13(a) or 15(d) of
the Exchange Act (all of the foregoing, including filings incorporated by reference therein, being
referred to herein as the “Commission Documents”). Except as previously disclosed to the
Investor in writing, since January 1, 2007 the Company has maintained all requirements for the
continued listing or quotation of its Common Stock, and such Common Stock is currently listed or
quoted on the NASDAQ Global Market. The Company has made available to the Investor true and
complete copies of the Commission Documents filed

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with the Commission since January 1, 2007 and prior to the Closing Date. The Company has not
provided to the Investor any information which, according to applicable law, rule or regulation,
should have been disclosed publicly by the Company but which has not been so disclosed, other than
with respect to the transactions contemplated by this Agreement. As of its date, the Company’s
Annual Report on Form 10-K for the year ended December 31, 2006 complied in all material respects
with the requirements of the Exchange Act and the rules and regulations of the Commission
promulgated thereunder applicable to such document, and, as of its date, after giving effect to the
information disclosed and incorporated by reference therein, to the Company’s Knowledge such Annual
Report on Form 10-K did not contain any untrue statement of a material fact or omit to state a
material fact required to be stated therein or necessary in order to make the statements therein,
in light of the circumstances under which they were made, not misleading. As of their respective
dates, to the Company’s Knowledge the financial statements, together with the related notes and
schedules thereto, of the Company included in the Commission Documents filed with the Commission
since January 1, 2007 complied as to form and substance in all material respects with all
applicable accounting requirements and the published rules and regulations of the Commission or
other applicable rules and regulations with respect thereto. Such financial statements, together
with the related notes and schedules thereto, have been prepared in accordance with generally
accepted accounting principles (“GAAP”) applied on a consistent basis during the periods
involved (except (i) as may be otherwise indicated in such financial statements or the notes
thereto or (ii) in the case of unaudited interim statements, to the extent they may not include
footnotes or may be condensed or summary statements), and fairly present in all material respects
the financial condition of the Company and its subsidiaries as of the dates thereof and the results
of operations and cash flows for the periods then ended (subject, in the case of unaudited
statements, to normal year-end audit adjustments).

          (b) The Company has timely filed with the Commission and made available to the Investor via
EDGAR or otherwise all certifications and statements required by (x) Rule 13a-14 or Rule 15d-14
under the Exchange Act or (y) 18 U.S.C. Section 1350 (Section 906 of the Sarbanes-Oxley Act of 2002
(“SOXA”)) with respect to all relevant Commission Documents. The Company is in compliance
in all material respects with the provisions of SOXA applicable to it as of the date hereof. The
Company maintains disclosure controls and procedures required by Rule 13a-15 or Rule 15d-15 under
the Exchange Act; such controls and procedures are effective to ensure that all material
information concerning the Company and its subsidiaries is made known on a timely basis to the
individuals responsible for the timely and accurate preparation of the Company’s filings with the
Commission and other public disclosure documents. As used in this Section 4.6(b), the term “file”
shall be broadly construed to include any manner in which a document or information is furnished,
supplied or otherwise made available to the Commission.

     Section 4.7 No Material Adverse Change. Except as disclosed in the Commission
Documents or a press release of the Company, since September 30, 2007 no event or series of events
has or have occurred that would, individually or in the aggregate, have a Material Adverse Effect
on the Company.

     Section 4.8 No Undisclosed Liabilities. To the Company’s Knowledge, neither the Company
nor any of its subsidiaries has any liabilities, obligations, claims or losses (whether liquidated
or unliquidated, secured or unsecured, absolute, accrued, contingent or otherwise) that

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would be required to be disclosed on a balance sheet of the Company or any subsidiary
(including the notes thereto) in conformity with GAAP and are not disclosed in the Commission
Documents, other than those incurred in the ordinary course of the Company’s or its subsidiaries
respective businesses since September 30, 2007 or which, individually or in the aggregate, do not
or would not have a Material Adverse Effect on the Company.

     Section 4.9 No Undisclosed Events or Circumstances. To the Company’s Knowledge, no
event or circumstance has occurred or exists with respect to the Company or its subsidiaries or
their respective businesses, properties, operations or financial condition, which, under applicable
law, rule or regulation, requires public disclosure or announcement by the Company but which has
not been so publicly announced or disclosed and which, individually or in the aggregate, would have
a Material Adverse Effect on the Company.

     Section 4.10 Actions Pending. There is no action, suit, claim, investigation or
proceeding pending or, to the Knowledge of the Company, threatened against the Company or any
subsidiary which questions the validity of this Agreement or the transactions contemplated hereby
or any action taken or to be taken pursuant hereto or thereto. Except as set forth in the
Commission Documents or in the Disclosure Schedule, there is no action, suit, claim, investigation
or proceeding pending or, to the Knowledge of the Company, threatened, against or involving the
Company, any subsidiary or any of their respective properties or assets, or to the Knowledge of the
Company involving any officers or directors, in their capacity as officers or directors, of the
Company or any of its subsidiaries, including, without limitation, any securities class action
lawsuit or stockholder derivative lawsuit, that could be reasonably expected to have a Material
Adverse Effect on the Company. Except as set forth in the Commission Documents or as previously
disclosed to the Investor in writing, no judgment, order, writ, injunction or decree or award has
been issued by or, to the Knowledge of the Company, requested of any court, arbitrator or
governmental agency which could be reasonably expected to result in a Material Adverse Effect.

     Section 4.11 Compliance with Law. The business of the Company and its subsidiaries
have been and are presently being conducted in accordance with all applicable federal, state, local
and foreign governmental laws, rules, regulations and ordinances, except as set forth in the
Commission Documents or such that would not reasonably be expected to cause a Material Adverse
Effect. Except as set forth in the Commission Documents, the Company and each of its subsidiaries
have all franchises, permits, licenses, consents and other governmental or regulatory
authorizations and approvals necessary for the conduct of its business as now being conducted by
it, except for such franchises, permits, licenses, consents and other governmental or regulatory
authorizations and approvals, the failure to possess which, individually or in the aggregate, could
not reasonably be expected to have a Material Adverse Effect.

     Section 4.12 Certain Fees. Except as expressly set forth in this Agreement, no
brokers, finders or financial advisory fees or commissions will be payable by the Company or any of
its subsidiaries in respect of the transactions contemplated by this Agreement.

     Section 4.13 Disclosure. To the Company’s Knowledge, neither this Agreement nor any
other documents, certificates or instruments furnished to the Investor by or on behalf of the
Company or any subsidiary in connection with the transactions contemplated by this Agreement

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contain any untrue statement of a material fact or omit to state a material fact necessary in
order to make the statements made herein or therein, in the light of the circumstances under which
they were made herein or therein, not misleading.

     Section 4.14 Material Non-Public Information. Except for this Agreement and the
transactions contemplated hereby, neither the Company nor its employees have disclosed to the
Investor, any material non-public information that, according to applicable law, rule or
regulation, should have been disclosed publicly by the Company prior to the date hereof but which
has not been so disclosed.

     Section 4.15 Exemption from Registration; Valid Issuances. Subject to, and in
reliance on, the representations, warranties and covenants made herein by the Investor, the
issuance and sale of the Shares, the Warrant, the Warrant Shares and any Blackout Shares in
accordance with the terms and on the bases of the representations and warranties set forth in this
Agreement, may and shall be properly issued pursuant to Section 4(2), Regulation D and/or any other
applicable federal and state securities laws. Neither the sales of the Shares, the Warrant, the
Warrant Shares or any Blackout Shares pursuant to, nor the Company’s performance of its obligations
under, this Agreement, the Registration Rights Agreement, or the Warrant shall (i) result in the
creation or imposition of any liens, charges, claims or other encumbrances upon the Shares, the
Warrant Shares, any Blackout Shares or any of the assets of the Company, or (ii) except as
previously disclosed to the Investor in writing, entitle the holders of any outstanding shares of
capital stock of the Company to preemptive or other rights to subscribe to or acquire the shares of
Common Stock or other securities of the Company.

     Section 4.16 No General Solicitation or Advertising in Regard to this
Transaction. Neither the Company nor any of its affiliates or any Person acting on its or
their behalf (i) has conducted any general solicitation (as that term is used in Rule 502(c) of
Regulation D) or general advertising with respect to any of the Shares, the Warrant, the Warrant
Shares or any Blackout Shares or (ii) has made any offers or sales of any security or solicited any
offers to buy any security under any circumstances that would require registration of the Shares
under the Securities Act.

     Section 4.17 No Integrated Offering. Neither the Company, nor any of its affiliates,
nor any person acting on its or their behalf has, directly or indirectly, made any offers or sales
of any security or solicited any offers to buy any security, other than pursuant to this Agreement
and employee benefit plans, under circumstances that would require integration under the Securities
Act of shares of the Common Stock issuable hereunder with any other offers or sales of securities
of the Company.

     Section 4.18 Acknowledgment Regarding Investor’s Purchase of Shares. The Company
acknowledges and agrees that the Investor is acting solely in the capacity of an arm’s length
investor with respect to this Agreement and the transactions contemplated hereunder. The Company
further acknowledges that the Investor is not acting as a financial advisor or fiduciary of the
Company (or in any similar capacity) with respect to this Agreement and the transactions
contemplated hereunder and any advice given by the Investor or any of its representatives or agents
in connection with this Agreement and the transactions contemplated hereunder is merely incidental
to the Investor’s purchase of the Shares.

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ARTICLE V

REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE INVESTOR

     The Investor hereby makes the following representations, warranties and covenants to the
Company:

     Section 5.1 Organization and Standing of the Investor. The Investor is a company duly
organized, validly existing and in good standing under the laws of the British Virgin Islands.

     Section 5.2 Authorization and Power. The Investor has the requisite power and
authority to enter into and perform its obligations under this Agreement, the Warrant and the
Registration Rights Agreement and to purchase the Shares, the Warrant and the Warrant Shares in
accordance with the terms hereof and thereof. The execution, delivery and performance of this
Agreement, the Warrant and the Registration Rights Agreement by Investor and the consummation by it
of the transactions contemplated hereby or thereby have been duly authorized by all necessary
corporate action, and no further consent or authorization of the Investor, its Board of Directors
or stockholders is required. Each of this Agreement and the Registration Rights Agreement has been
duly executed and delivered by the Investor and constitutes a valid and binding obligation of the
Investor enforceable against the Investor in accordance with its terms, except as such
enforceability may be limited by applicable bankruptcy, insolvency, reorganization, moratorium,
liquidation, conservatorship, receivership, or similar laws relating to, or affecting generally the
enforcement of creditor’s rights and remedies or by other equitable principles of general
application.

     Section 5.3 No Conflicts. The execution, delivery and performance of this Agreement,
the Registration Rights Agreement, the Warrant and any other document or instrument contemplated
hereby, by the Investor and the consummation of the transactions contemplated thereby do not
(i) violate any provision of the Investor’s charter documents or bylaws, (ii) conflict with, or
constitute a default (or an event which with notice or lapse of time or both would become a
default) under, or give to others any rights of termination, amendment, acceleration or
cancellation of, any material agreement, mortgage, deed of trust, indenture, note, bond, license,
lease agreement, instrument or obligation to which the Investor is a party, (iii) create or impose
a lien, charge or encumbrance on any property of the Investor under any agreement or any commitment
to which the Investor is a party or by which the Investor is bound or by which any of its
respective properties or assets are bound, (iv) result in a violation of any federal, state, local
or foreign statute, rule, regulation, order, writ, judgment or decree (including federal and state
securities laws and regulations) applicable to the Investor or by which any property or asset of
the Investor are bound or affected, or (v) require the consent of any third-party that has not been
obtained pursuant to any material contract to which Investor is subject or to which any of its
assets, operations or management may be subject. The Investor is not required under federal, state
or local law, rule or regulation to obtain any consent, authorization or order of, or make any
filing or registration with, any court or governmental agency in order for it to execute, deliver
or perform any of its obligations under this Agreement or to purchase the Shares or the Warrant in
accordance with the terms hereof, provided that, for purposes of the representation made in this
sentence, the Investor is assuming and relying upon the accuracy of the relevant representations
and agreements of the Company herein.

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     Section 5.4 Financial Capability. The Investor has the financial capability to
perform all of its obligations under this Agreement, including the capability to purchase the
Shares, the Warrant and the Warrant Shares in accordance with the terms hereof. The Investor has
such knowledge and experience in business and financial matters that it is capable of evaluating
the merits and risks of an investment in Common Stock. The Investor is an “accredited
investor” as defined in Regulation D. The Investor is a “sophisticated investor” as
described in Rule 506(b)(2)(ii) of Regulation D. The Investor acknowledges that an investment in
the Common Stock and the Warrant is speculative and involves a high degree of risk.

     Section 5.5 Information. The Investor and its advisors, if any, have been furnished
with all materials relating to the business, finances and operations of the Company and materials
relating to the offer and sale of the Shares, the Warrant and the Warrant Shares which have been
requested by the Investor. The Investor has reviewed or received copies of the Commission
Documents. The Investor and its advisors, if any, have been afforded the opportunity to ask
questions of the Company. The Investor has sought such accounting, legal and tax advice as it has
considered necessary to make an informed investment decision with respect to its acquisition of the
Shares, the Warrant and the Warrant Shares. Except for this Agreement and the transactions
contemplated hereby, neither the Company nor any of its officers, directors or employees has
disclosed to the Investor any material non-public information that, according to applicable law,
rule or regulation, should have been disclosed publicly by the Company prior to the date hereof but
which has not been so disclosed. The Investor understands that it (and not the Company) shall be
responsible for its own tax liabilities that may arise as a result of this investment or the
transactions contemplated by this Agreement.

     Section 5.6 Trading Restrictions. The Investor covenants that neither the Investor
nor any of its affiliates nor any entity managed or controlled by the Investor will, or cause or
assist any Person to, enter into or execute any “short sale” (as such term is defined in
Rule 200 of Regulation SHO, or any successor regulation, promulgated by the Commission under the
Exchange Act) of any securities of the Company, and that the Investor and its affiliates shall
comply with all other applicable laws.

     Section 5.7 Statutory Underwriter Status. The Investor acknowledges that, pursuant to
the Commission’s current interpretations of the Securities Act, the Investor will be disclosed as
an “underwriter” within the meaning of the Securities Act in the Registration Statement
(and amendments thereto) and in any Prospectus contained therein to the extent required by
applicable law.

     Section 5.8 Not an Affiliate. The Investor is not an officer, director or
“affiliate” (as defined in Rule 405 of the Securities Act) of the Company.

     Section 5.9 Manner of Sale. At no time was Investor presented with or solicited by or
through any leaflet, public promotional meeting, television advertisement or any other form of
general solicitation or advertising.

     Section 5.10 Prospectus Delivery. The Investor agrees that unless the Shares and
Warrant Shares are eligible for resale pursuant to all the conditions of Rule 144, it will resell
the Shares and Warrant Shares only pursuant to the Registration Statement, in a manner described

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under the caption “Plan of Distribution” in the Registration Statement, and in a
manner in compliance with all applicable securities laws, including, without limitation, any
applicable prospectus delivery requirements of the Securities Act and the insider trading
restrictions of the Exchange Act.

ARTICLE VI

COVENANTS OF THE COMPANY

     The Company covenants with the Investor as follows, which covenants are for the benefit of the
Investor and its permitted assignees (as defined herein):

     Section 6.1 Securities Compliance. The Company shall notify the Commission and the
Principal Market, if and as applicable, in accordance with their respective rules and regulations,
of the transactions contemplated by this Agreement, and shall use commercially reasonable efforts
to take all other necessary action and proceedings as may be required and permitted by applicable
law, rule and regulation, for the legal and valid issuance of the Shares, the Warrant Shares and
the Blackout Shares, if any, to the Investor. Each Commission Document to be filed with the
Commission after the Closing Date and incorporated by reference in the Registration Statement and
Prospectus, when such document becomes effective or is filed with the Commission, as the case may
be, shall comply in all material respects with the requirements of the Securities Act or the
Exchange Act, as applicable, and other federal, state and local laws, rules and regulations
applicable to it, and shall not contain any untrue statement of a material fact or omit to state a
material fact required to be stated therein or necessary in order to make the statements therein,
in light of the circumstances under which they were made, not misleading.

     Section 6.2 Reservation of Common Stock. As of the date hereof, the Company has
available and the Company shall reserve and keep available at all times, free of preemptive rights
and other similar contractual rights of stockholders, shares of Common Stock for the purpose of
enabling the Company to satisfy any obligation to issue the Shares in connection with all Draw
Downs contemplated hereunder and the Warrant Shares. The number of shares so reserved from time to
time, as theretofore increased or reduced as hereinafter provided, may be reduced by the number of
shares actually delivered hereunder.

     Section 6.3 Registration and Listing. During the Commitment Period, the Company shall
use commercially reasonable efforts to: (i) cause its Common Stock to continue to be registered
under Section 12(b) or 12(g) of the Exchange Act, (ii) comply in all respects with its reporting
and filing obligations under the Exchange Act, and (iii) prevent the termination or suspension of
such registration, or the termination or suspension of its reporting and filing obligations under
the Exchange Act or Securities Act (except as expressly permitted herein). The Company shall use
commercially reasonable efforts to maintain the listing and trading of its Common Stock and the
listing of the Shares purchased by Investor hereunder on the Principal Market (including, without
limitation, maintaining sufficient net tangible assets) and will comply in all material respects
with the Company’s reporting, filing and other obligations under the bylaws or rules of the FINRA
and the Principal Market. The Company will not be required to carry out any action pursuant to
this Agreement, the Registration Rights Agreement or the Warrant that would adversely impact the
listing of the Company’s securities on the Principal

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Market as now in effect, and as may be changed by the Company in the future in the Company’s
discretion.

     Section 6.4 Registration Statement. Without the prior written consent of the
Investor, the Registration Statement shall be used solely in connection with the transactions
between the Company and the Investor contemplated hereby.

     Section 6.5 Compliance with Laws.

          (a) The Company shall comply, and cause each subsidiary to comply, with all applicable laws,
rules, regulations and orders, noncompliance with which could reasonably be expected to have a
Material Adverse Effect. Without limiting the generality of the foregoing, neither the Company nor
any of its officers, directors or affiliates has taken or will take, directly or indirectly, any
action designed or intended to stabilize or manipulate the price of any security of the Company, or
which caused or resulted in, or which would in the future reasonably be expected to cause or result
in, stabilization or manipulation of the price of any security of the Company.

          (b) Without the consent of its stockholders in accordance with FINRA and The NASDAQ Stock
Market LLC rules, the Company will not be obligated to issue, and the Investor will not be
obligated to purchase, any Shares or Blackout Shares which would result in the issuance under this
Agreement, the Warrant and the Registration Rights Agreement of Shares and Blackout Shares
(collectively) representing more than the applicable percentage under the rules of the FINRA and
The NASDAQ Stock Market LLC , including, without limitation, NASDAQ Marketplace Rule 4350(i), that
would require stockholder approval of the issuance thereof. Nothing herein shall compel the
Company to seek such consent of its stockholders.

     Section 6.6 Other Financing. Nothing in this Agreement shall be construed to restrict
the right of the Company to offer, sell and/or issue securities of any kind whatsoever, provided
such transaction is not a Prohibited Transaction (as defined below) (any such transaction that is
not a Prohibited Transaction is referred to in this Agreement as a “Permitted
Transaction”). Without limiting the generality of the preceding sentence, the Company may,
without the prior written consent of the Investor, (i) establish stock option or award plans or
agreements (for directors, employees, consultants and/or advisors), and issue securities
thereunder, and amend such plans or agreements, including increasing the number of shares available
thereunder, (ii) issue equity securities to finance, or otherwise in connection with, the
acquisition of one or more other companies, equipment, technologies or lines of business, (iii)
issue shares of Common Stock and/or Preferred Stock in connection with the Company’s option or
award plans, stock purchase plans, rights plans, warrants or options, (iv) issue shares of Common
Stock and/or Preferred Stock in connection with the acquisition of products, licenses, equipment or
other assets and strategic partnerships or joint ventures; (v) issue shares of Common and/or
Preferred Stock to consultants and/or advisors as consideration for services rendered or to be
rendered, (vi) issue and sell equity or debt securities in a public offering, (vii) issue and sell
and equity or debt securities in a private placement (other than in connection with any Prohibited
Transaction), (viii) issue equity securities to equipment lessors, equipment vendors, banks or
similar lending institutions in connection with leases or loans, or in connection with strategic
commercial or licensing transactions, (ix) issue securities in connection with any stock split,
stock dividend,

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recapitalization, reclassification or similar event by the Company, and (x) issue shares of
Common Stock to the Investor under any other agreement entered into between the Investor and the
Company.

     Section 6.7 Prohibited Transactions. Except as set forth on Schedule 6.7 hereof,
during the term of this Agreement, the Company shall not enter into any Prohibited Transaction
without the prior written consent of the Investor, which consent may be withheld at the sole
discretion of the Investor. For the purposes of this Agreement, the term “Prohibited
Transaction” shall refer to the issuance by the Company of any “future priced securities,”
which shall mean the issuance of shares of Common Stock or securities of any type whatsoever that
are, or may become, convertible or exchangeable into shares of Common Stock where the purchase,
conversion or exchange price for such Common Stock is determined using any floating discount or
other post-issuance adjustable discount to the market price of Common Stock, including, without
limitation, pursuant to any equity line or other financing that is substantially similar to the
financing provided for under this Agreement.

     Section 6.8 Corporate Existence. The Company shall take all commercially reasonable
steps necessary to preserve and continue the corporate existence of the Company; provided, however,
that nothing in this Agreement shall be deemed to prohibit the Company from engaging in any
Excluded Merger or Sale with another Person provided that in the event of an Excluded Merger or
Sale, if the surviving, successor or purchasing Person does not agree to assume the obligations
under the Warrant, then the Company shall deliver a notice to the Investor at least ten (10) days
before the consummation of such Excluded Merger or Sale (provided that, to the extent that such
transaction has not been publicly disclosed, then the Investor agrees to maintain the
confidentiality of such information and to use such information only in connection with a decision
to exercise the Warrant), the Investor may exercise the Warrant at any time before the consummation
of such Excluded Merger or Sale (and such exercise may be made contingent upon the consummation of
such Excluded Merger or Sale), and any portion of the Warrant that has not been exercised before
consummation of such Excluded Merger or Sale shall terminate and expire, and shall no longer be
outstanding.

     Section 6.9 Non-Disclosure of Non-Public Information. Except as otherwise expressly
provided in this Agreement, the Registration Rights Agreement or the Warrant, none of the Company,
its officers, directors, employees nor agents shall disclose material non-public information to the
Investor, its advisors or representatives.

     Section 6.10 Notice of Certain Events Affecting Registration; Suspension of Right to
Request a Draw Down. The Company shall promptly notify the Investor upon the occurrence of any
of the following events in respect of the Registration Statement or the Prospectus related to the
offer, issuance and sale of the Shares and the Warrant Shares hereunder: (i) receipt of any request
for additional information by the Commission or any other federal or state governmental authority
during the period of effectiveness of the Registration Statement for amendments or supplements to
the Registration Statement or the Prospectus; (ii) the issuance by the Commission or any other
federal or state governmental authority of any stop order suspending the effectiveness of the
Registration Statement or the initiation of any proceedings for that purpose; (iii) receipt of any
notification with respect to the suspension of the qualification or exemption from qualification of
any of the Registrable Securities for sale in any jurisdiction or the initiation

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or threatening of any proceeding for such purpose; and (iv) the Company becoming aware of the
happening of any event, which makes any statement of a material fact made in the Registration
Statement or Prospectus untrue or which requires the making of any additions to or changes to the
statements then made in the Registration Statement or Prospectus in order to state a material fact
required by the Securities Act to be stated therein or necessary in order to make the statements
then made therein, in light of the circumstances under which they were made, not misleading, or of
the necessity to amend the Registration Statement or supplement the Prospectus to comply with the
Securities Act or any other law. If at any time the Commission shall issue any stop order
suspending the effectiveness of the Registration Statement, the Company shall use commercially
reasonable efforts to obtain the withdrawal of such order at the earliest possible time. The
Company shall not be required to disclose to the Investor the substance or specific reasons of any
of the events set forth in clauses (i) through (ii) of the previous sentence, only that the event
has occurred. The Company shall not request a Draw Down during the continuation of any of the
foregoing events.

     Section 6.11 Amendments to the Registration Statement. After the Registration
Statement has been declared effective by the Commission, and for so long as it remains effective,
the Company shall not file any amendment to the Registration Statement or make any amendment or
supplement to the Prospectus of which the Investor shall not previously have been advised. In
addition, so long as, in the reasonable opinion of counsel for the Investor, a Prospectus is
required to be delivered in connection with sales of the Shares by the Investor, if the Company
files any information, documents or reports that are incorporated by reference in the Registration
Statement pursuant to the Exchange Act, the Company shall, if requested in writing by the Investor,
deliver a copy of such information, documents or reports to the Investor promptly following such
filing.

     Section 6.12 Prospectus Delivery. From time to time for such period as in the
reasonable opinion of counsel for the Investor a prospectus is required by the Securities Act to be
delivered in connection with sales by the Investor, the Company will expeditiously deliver to the
Investor, without charge, as many copies of the Prospectus (and of any amendment or supplement
thereto) as the Investor may reasonably request. The Company consents to the use of the Prospectus
(and of any amendment or supplement thereto) in accordance with the provisions of the Securities
Act and state securities laws in connection with the offering and sale of the Shares and the
Warrant Shares and for such period of time thereafter as the Prospectus is required by the
Securities Act to be delivered in connection with sales of the Shares and the Warrant Shares.

ARTICLE VII

CONDITIONS TO THE OBLIGATION OF THE INVESTOR

TO ACCEPT A DRAW DOWN

     The obligation of the Investor hereunder to accept a Draw Down Notice and to acquire and pay
for the Shares in accordance therewith is subject to the satisfaction or waiver, at each Condition
Satisfaction Date, of each of the conditions set forth below. Other than those conditions set
forth in Section 7.12 which are for the Company’s sole benefit and may be waived by the Company at
any time in its sole discretion, the conditions are for the Investor’s sole benefit and may be
waived by the Investor at any time in its sole discretion. As used in this

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Agreement, the term “Condition Satisfaction Date” shall mean, with respect to each
Draw Down, the date on which the applicable Draw Down Notice is delivered to the Investor and each
Settlement Date in respect of the applicable Draw Down Pricing Period.

     Section 7.1 Accuracy of the Company’s Representations and Warranties. Each of the
representations and warranties of the Company shall be true and correct in all material respects as
of the date when made as though made at that time except for representations and warranties that
are expressly made as of a particular date.

     Section 7.2 Performance by the Company. The Company shall have, in all material
respects, performed, satisfied and complied with all covenants, agreements and conditions required
by this Agreement, the Registration Rights Agreement and the Warrant to be performed, satisfied or
complied with by the Company.

     Section 7.3 Compliance with Law. The Company shall have complied in all respects with
all applicable federal, state and local governmental laws, rules, regulations and ordinances in
connection with the execution, delivery and performance of this Agreement and the consummation of
the transactions contemplated hereby except for any failures to so comply which could not
reasonably be expected to have a Material Adverse Effect.

     Section 7.4 Effective Registration Statement. Upon the terms and subject to the
conditions set forth in the Registration Rights Agreement, the Registration Statement shall have
previously become effective and shall remain effective and (i) neither the Company nor the Investor
shall have received notice that the Commission has issued or intends to issue a stop order with
respect to the Registration Statement or that the Commission otherwise has suspended or withdrawn
the effectiveness of the Registration Statement, either temporarily or permanently, or intends or
has threatened to do so (unless the Commission’s concerns have been addressed and the Investor is
reasonably satisfied that the Commission no longer is considering or intends to take such action),
and (ii) no other suspension of the use or withdrawal of the effectiveness of the Registration
Statement or the Prospectus shall exist.

     Section 7.5 No Knowledge. The Company shall have no Knowledge of any event that could
reasonably be expected to have the effect of causing the Registration Statement with respect to the
resale of the Registrable Securities by the Investor to be suspended or otherwise ineffective
(which event is reasonably likely to occur within eight Trading Days following the Trading Day on
which a Draw Down Notice is delivered) as of the Settlement Date.

     Section 7.6 No Suspension. Trading in the Company’s Common Stock shall not have been
suspended by the Commission, the Principal Market or the FINRA and trading in securities generally
as reported on the Principal Market shall not have been suspended or limited.

     Section 7.7 No Injunction. No statute, rule, regulation, order, decree, writ, ruling
or injunction shall have been enacted, entered, promulgated, threatened or endorsed by any court or
governmental authority of competent jurisdiction which prohibits the consummation of any of the
transactions contemplated by this Agreement.

     Section 7.8 No Proceedings or Litigation. No action, suit or proceeding before any
arbitrator or any court or governmental authority shall have been commenced or, to the

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Knowledge of the Company threatened, and, to the Knowledge of the Company no inquiry or
investigation by any governmental authority shall have been threatened, against the Company or any
subsidiary, or any of the officers, directors or affiliates of the Company or any subsidiary
seeking to enjoin, prevent or change the transactions contemplated by this Agreement, or seeking
damages in connection with such transactions.

     Section 7.9 Sufficient Shares Registered for Resale. The Company shall have
sufficient Shares, calculated using the closing trade price of the Common Stock as of the Trading
Day immediately preceding such Draw Down Notice, registered under the Registration Statement to
issue and sell such Shares in accordance with such Draw Down Notice.

     Section 7.10 Warrant. The Warrant shall have been duly executed, delivered and issued
to the Investor, and the Company shall not be in default in any material respect under any of the
provisions thereof, provided that any refusal by or failure of the Company to issue and deliver
Warrant Shares in respect of any exercise (in whole or in part) thereof shall be deemed to be
material for the purposes of this Section 7.10.

     Section 7.11 Opinion of Counsel. The Investor shall have received the form of opinion
mutually agreed to between the parties on the date of this Agreement.

     Section 7.12 Accuracy of Investor’s Representation and Warranties. The
representations and warranties of the Investor shall be true and correct in all material respects
as of the date when made as though made at that time except for representations and warranties that
are made as of a particular date.

ARTICLE VIII

TERMINATION

     Section 8.1 Term. Unless otherwise terminated in accordance with Section 8.2 below,
this Agreement shall terminate upon the earlier to occur of (i) the expiration of the Commitment
Period or (ii) the issuance of Shares pursuant to this Agreement in an amount equal to the Maximum
Commitment Amount.

     Section 8.2 Other Termination.

               (a) The Investor may terminate this Agreement upon (x) one (1) business day’s notice if the
Company enters into any Prohibited Transaction as set forth in Section 6.7 without the Investor’s
prior written consent, or (y) one (1) business day’s notice if the Investor provides written notice
of a Material Adverse Effect to the Company, and such Material Adverse Effect continues for a
period of ten (10) Trading Days after the receipt by the Company of such notice.

               (b) The Investor may terminate this Agreement upon one (1) business day’s notice to the
Company at any time in the event that the Registration Statement is not initially declared
effective in accordance with the Registration Rights Agreement, provided, however, that in the
event the Registration Statement is declared effective prior to the delivery of such notice, the
Investor shall thereafter have no right to terminate this Agreement pursuant to this Section
8.2(b).

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               (c) The Company may terminate this Agreement upon one (1) business day’s notice; provided,
however, that the Company shall not terminate this Agreement pursuant to this Section 8.2(c) during
any Draw Down Pricing Period; provided further, that, in the event of any termination of this
Agreement by the Company hereunder, so long as the Investor owns Shares purchased hereunder and/or
Warrant Shares, unless all of such shares of Common Stock may be resold by the Investor without
registration and without any time, volume or manner limitations pursuant to Rule 144(b)(1)(i) (or
any similar provision then in effect) under the Securities Act, the Company shall not suspend,
except as provided for in the Registration Rights Agreement and the conditions and limitations set
forth therein, or withdraw the Registration Statement or otherwise cause the Registration Statement
to become ineffective, or voluntarily delist the Common Stock from, the Principal Market without
listing the Common Stock on another Principal Market.

               (d) Each of the parties hereto may terminate this Agreement upon one (1) day’s notice if the
other party has breached a material representation, warranty or covenant to this Agreement and such
breach is not remedied within ten (10) Trading Days after notice of such breach is delivered to the
breaching party.

     Section 8.3 Effect of Termination. In the event of termination by the Company or the
Investor, written notice thereof shall forthwith be given to the other party and the transactions
contemplated by this Agreement shall be terminated without further action by either party. If this
Agreement is terminated as provided in Section 8.1 or 8.2 herein, this Agreement shall become void
and of no further force and effect, except as provided in Section 10.13. Nothing in this Section
8.3 shall be deemed to release the Company or the Investor from any liability for any breach under
this Agreement occurring prior to such termination, or to impair the rights of the Company and the
Investor to compel specific performance by the other party of its obligations under this Agreement
arising prior to such termination.

ARTICLE IX

INDEMNIFICATION

     Section 9.1 Indemnification.

               (a) Except as otherwise provided in this Article IX, unless disputed as set forth in Section
9.2, the Company agrees to indemnify, defend and hold harmless the Investor and its affiliates and
their respective officers, directors, agents, employees, subsidiaries, partners, members and
controlling persons (each, an “Investor Indemnified Party”), to the fullest extent
permitted by law from and against any and all Damages directly resulting from or directly arising
out of any breach of any representation or warranty, covenant or agreement (except as otherwise
specifically provided) by the Company in this Agreement, the Registration Rights Agreement or the
Warrant; provided, however, that the Company shall not be liable under this Article IX to an
Investor Indemnified Party to the extent that such Damages resulted or arose from the breach by an
Investor Indemnified Party of any representation, warranty, covenant or agreement of an Investor
Indemnified Party contained in this Agreement, the Registration Rights Agreement or the Warrant or
the negligence, recklessness, willful misconduct or bad faith of an Investor Indemnified Party.
The parties intend that any Damages subject to indemnification pursuant to this Article IX will be
net of insurance proceeds (which the Investor Indemnified Party agrees to

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use commercially reasonable efforts to recover). Accordingly, the amount which the Company is
required to pay to any Investor Indemnified Party hereunder (a “Company Indemnity Payment”)
will be reduced by any insurance proceeds actually recovered by or on behalf of any Investor
Indemnified Party in reduction of the related Damages. In addition, if an Investor Indemnified
Party receives a Company Indemnity Payment required by this Article IX in respect of any Damages
and subsequently receives any such insurance proceeds, then the Investor Indemnified Party will pay
to the Company an amount equal to the Company Indemnity Payment received less the amount of the
Company Indemnity Payment that would have been due if the insurance proceeds had been received,
realized or recovered before the Company Indemnity Payment was made.

               (b) Except as otherwise provided in this Article IX, unless disputed as set forth in Section
9.2, the Investor agrees to indemnify, defend and hold harmless the Company and its affiliates and
their respective officers, directors, agents, employees, subsidiaries, partners, members and
controlling persons (each, a “Company Indemnified Party”), to the fullest extent permitted
by law from and against any and all Damages directly resulting from or directly arising out of any
breach of any representation or warranty, covenant or agreement by the Investor in this Agreement,
the Registration Rights Agreement or the Warrant; provided, however, that the Investor shall not be
liable under this Article IX to a Company Indemnified Party to the extent that such Damages
resulted or arose from the breach by a Company Indemnified Party of any representation, warranty,
covenant or agreement of a Company Indemnified Party contained in this Agreement, the Registration
Rights Agreement or the Warrant or negligence, recklessness, willful misconduct or bad faith of a
Company Indemnified Party. The parties intend that any Damages subject to indemnification pursuant
to this Article IX will be net of insurance proceeds (which the Company agrees to use commercially
reasonable efforts to recover). Accordingly, the amount which the Investor is required to pay to
any Company Indemnified Party hereunder (an “Investor Indemnity Payment”) will be reduced
by any insurance proceeds theretofore actually recovered by or on behalf of any Company Indemnified
Party in reduction of the related Damages. In addition, if a Company Indemnified Party receives an
Investor Indemnity Payment required by this Article IX in respect of any Damages and subsequently
receives any such insurance proceeds, then the Company Indemnified Party will pay to the Investor
an amount equal to the Investor Indemnity Payment received less the amount of the Investor
Indemnity Payment that would have been due if the insurance proceeds had been received, realized or
recovered before the Investor Indemnity Payment was made.

     Section 9.2 Notification of Claims for Indemnification. Each party entitled to
indemnification under this Article IX (an “Indemnified Party”) shall, promptly after the
receipt of notice of the commencement of any claim against such Indemnified Party in respect of
which indemnity may be sought from the party obligated to indemnify such Indemnified Party under
this Article IX (the “Indemnifying Party”), notify the Indemnifying Party in writing of the
commencement thereof. Any such notice shall describe the claim in reasonable detail. The failure
of any Indemnified Party to so notify the Indemnifying Party of any such action shall not relieve
the Indemnifying Party from any liability which it may have to such Indemnified Party (a) other
than pursuant to this Article IX or (b) under this Article IX unless, and only to the extent that,
such failure results in the Indemnifying Party’s forfeiture of substantive rights or defenses or
the Indemnifying Party is prejudiced by such delay. The procedures listed below shall govern the
procedures for the handling of indemnification claims.

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               (a) Any claim for indemnification for Damages that do not result from a Third Party Claim as
defined in the following paragraph, shall be asserted by written notice given by the Indemnified
Party to the Indemnifying Party. Such Indemnifying Party shall have a period of thirty (30) days
after the receipt of such notice within which to respond thereto. If such Indemnifying Party does
not respond within such thirty (30) day period, such Indemnifying Party shall be deemed to have
refused to accept responsibility to make payment as set forth in Section 9.1. If such Indemnifying
Party does not respond within such thirty (30) day period or rejects such claim in whole or in
part, the Indemnified Party shall be free to pursue such remedies as specified in this Agreement.

               (b) If an Indemnified Party shall receive notice or otherwise learn of the assertion by a
person or entity not a party to this Agreement of any threatened legal action or claim
(collectively a “Third Party Claim”), with respect to which an Indemnifying Party may be
obligated to provide indemnification, the Indemnified Party shall give such Indemnifying Party
written notice thereof within twenty (20) days after becoming aware of such Third Party Claim.

               (c) An Indemnifying Party may elect to defend (and, unless the Indemnifying Party has
specified any reservations or exceptions, to seek to settle or compromise) at such Indemnifying
Party’s own expense and by such Indemnifying Party’s own counsel, any Third Party Claim. Within
thirty (30) days after the receipt of notice from an Indemnified Party (or sooner if the nature of
such Third Party Claim so requires), the Indemnifying Party shall notify the Indemnified Party
whether the Indemnifying Party will assume responsibility for defending such Third Party Claim,
which election shall specify any reservations or exceptions. If such Indemnifying Party does not
respond within such thirty (30) day period or rejects such claim in whole or in part, the
Indemnified Party shall be free to pursue such remedies as specified in this Agreement. In case
any such Third Party Claim shall be brought against any Indemnified Party, and it shall notify the
Indemnifying Party of the commencement thereof, the Indemnifying Party shall be entitled to assume
the defense thereof at its own expense, with counsel satisfactory to such Indemnified Party in its
reasonable judgment; provided, however, that any Indemnified Party may, at its own expense, retain
separate counsel to participate in such defense at its own expense. Notwithstanding the foregoing,
in any Third Party Claim in which both the Indemnifying Party, on the one hand, and an Indemnified
Party, on the other hand, are, or are reasonably likely to become, a party, such Indemnified Party
shall have the right to employ separate counsel and to control its own defense of such claim if, in
the reasonable opinion of counsel to such Indemnified Party, either (x) one or more significant
defenses are available to the Indemnified Party that are not available to the Indemnifying Party or
(y) a conflict or potential conflict exists between the Indemnifying Party, on the one hand, and
such Indemnified Party, on the other hand, that would make such separate representation advisable;
provided, however, that in such circumstances the Indemnifying Party (i) shall not be liable for
the fees and expenses of more than one counsel to all Indemnified Parties and (ii) shall reimburse
the Indemnified Parties for such reasonable fees and expenses of such counsel incurred in any such
Third Party Claim, as such expenses are incurred, provided that the Indemnified Parties agree to
repay such amounts if it is ultimately determined that the Indemnifying Party was not obligated to
provide indemnification under this Article IX. The Indemnifying Party agrees that it will not
compromise or consent to the entry of any judgment in any pending or threatened claim relating to
the matters contemplated hereby (if any Indemnified Party is a party thereto or has been actually
threatened to be made a party thereto) unless such settlement, compromise or consent

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includes an unconditional release of such Indemnified Party from all liability arising or that
may arise out of such claim. The Indemnifying Party shall not be liable for any settlement of any
claim effected against an Indemnified Party without the Indemnifying Party’s prior written consent,
which consent shall not be unreasonably withheld, conditioned or delayed. The rights accorded to
an Indemnified Party hereunder shall be in addition to any rights that any Indemnified Party may
have at common law, by separate agreement or otherwise; provided, however, that notwithstanding the
foregoing or anything to the contrary contained in this Agreement, nothing in this Article IX shall
restrict or limit any rights that any Indemnified Party may have to seek equitable relief.

ARTICLE X

MISCELLANEOUS

     Section 10.1 Fees and Expenses.

               (a) Each of the Company and the Investor agrees to pay its own expenses incident to the
performance of its obligations hereunder, except that the Company shall be solely responsible for
(i) all reasonable attorneys fees and expenses incurred by the Investor in connection with the
preparation, negotiation, execution and delivery of this Agreement, the Registration Rights
Agreement and the Warrant, and review of the Registration Statement, and in connection with any
amendments, modifications or waivers of this Agreement, including, without limitation, all
reasonable attorneys fees and expenses, (ii) subject in all cases to Section 10.1(b) hereof, all
reasonable fees and expenses incurred in connection with the Investor’s enforcement of this
Agreement, including, without limitation, all reasonable attorneys fees and expenses, (iii) due
diligence expenses incurred by the Investor during the term of this Agreement equal to $12,500 per
calendar quarter, and (iv) all stamp or other similar taxes and duties, if any, levied in
connection with issuance of the Shares pursuant hereto; provided, however, that in each of the
above instances the Investor shall provide customary supporting invoices or similar documentation
in reasonable detail describing such expenses (however, the Investor shall not be obligated to
provide detailed time sheets); and provided further, that the maximum aggregate amount payable by
the Company pursuant to clause (i) above shall be $75,000 and the Investor shall bear all fees and
expenses in excess of $75,000 in connection with clause (i) above.

               (b) If any action at law or in equity is necessary to enforce or interpret the terms of this
Agreement, the Registration Rights Agreement or the Warrant, the prevailing party shall be entitled
to reasonable fees, costs and necessary disbursements in addition to any other relief to which such
party may be entitled.

     Section 10.2 Reporting Entity for the Common Stock. The reporting entity relied upon
for the determination of the trading price or trading volume of the Common Stock on any given
Trading Day for the purposes of this Agreement shall be Bloomberg, L.P. or any successor thereto.
The written mutual consent of the Investor and the Company shall be required to employ any other
reporting entity.

     Section 10.3 Brokerage. Each of the parties hereto represents that it has had no
dealings in connection with this transaction with any finder or broker who will demand payment of
any fee or commission from the other party. The Company on the one hand, and the Investor,

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on the other hand, agree to indemnify the other against and hold the other harmless from any
and all liabilities to any Persons claiming brokerage commissions or finder’s fees on account of
services purported to have been rendered on behalf of the indemnifying party in connection with
this Agreement or the transactions contemplated hereby.

     Section 10.4 Notices. All notices, demands, requests, consents, approvals, and other
communications required or permitted hereunder shall be in writing and, unless otherwise specified
herein, shall be (i) personally served, (ii) deposited in the mail, registered or certified, return
receipt requested, postage prepaid, (iii) delivered by reputable air courier service with charges
prepaid, or (iv) transmitted by hand delivery, telegram, or facsimile, addressed as set forth below
or to such other address as such party shall have specified most recently by written notice given
in accordance herewith, in each case with a copy to the e-mail address set forth beside the
facsimile number for the addressee below. Any notice or other communication required or permitted
to be given hereunder shall be deemed effective (a) upon hand delivery or delivery by facsimile,
with accurate confirmation generated by the transmitting facsimile machine, at the address or
number designated below (if delivered on a business day during normal business hours where such
notice is to be received), or the first business day following such delivery (if delivered other
than on a business day during normal business hours where such notice is to be received) or (b) on
the second business day following the date of mailing by express courier service, fully prepaid,
addressed to such address, or upon actual receipt of such mailing, whichever shall first occur.
The addresses for such communications shall be:

If to the Company:

OXiGENE, Inc.

230 Third Avenue

Waltham, MA 02451

Facsimile: 781-547-6800

Attention: Richard Chin, M.D.

with a copy (which shall not constitute notice) to:

Mintz Levin Cohn Ferris Glovsky and Popeo P.C.

One Financial Center

Boston, MA 02111

Facsimile: 617-542-2241

Attention: Megan N. Gates, Esq.

if to the Investor:

Kingsbridge Capital Limited

Attention: Mr. Tony Hillman

P.O. Box 1075

Elizabeth House

9 Castle Street

St. Helier

Jersey

JE42QP

Channel Islands

Telephone: 011-44-1534-636-041

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Facsimile: 011-44-1534-636-042

Email: admin@kingsbridgecap.com; and adamgurney@kingsbridgecap.com

with a copy (which shall not constitute notice) to:

Kingsbridge Corporate Services Limited

Kingsbridge House

New Abbey

Kilcullen, County Kildare

Republic of Ireland

Telephone: 011-353-45-481-811

Facsimile: 011-353-45-482-003

Email: adamgurney@kingsbridge.ie; emmagalway@kingsbridge.ie; and

pwhelan@kingsbridge.ie

and another copy (which shall not constitute notice) to:

Stroock & Stroock & Lavan LLP

180 Maiden Lane

New York, NY 10038

Facsimile: (212) 806-5400

Attention: Keith M. Andruschak, Esq. – kandruschak@stroock.com

     Either party hereto may from time to time change its address for notices under this Section by
giving at least ten (10) days’ prior written notice of such changed address to the other party
hereto.

     Section 10.5 Assignment. Neither this Agreement nor any rights of the Investor or the
Company hereunder may be assigned by either party to any other Person.

     Section 10.6 Amendment; No Waiver. No party shall be liable or bound to any other
party in any manner by any warranties, representations or covenants except as specifically set
forth in this Agreement, the Warrant and the Registration Rights Agreement. Except as expressly
provided in this Agreement, neither this Agreement nor any term hereof may be amended, waived,
discharged or terminated other than by a written instrument signed by both parties hereto. The
failure of the either party to insist on strict compliance with this Agreement, or to exercise any
right or remedy under this Agreement, shall not constitute a waiver of any rights provided under
this Agreement, nor estop the parties from thereafter demanding full and complete compliance nor
prevent the parties from exercising such a right or remedy in the future.

     Section 10.7 Entire Agreement. This Agreement, the Registration Rights Agreement and
the Warrant set forth the entire agreement and understanding of the parties relating to the subject
matter hereof and supersedes all prior and contemporaneous agreements, negotiations and
understandings between the parties, both oral and written, relating to the subject matter hereof.

     Section 10.8 Severability. If any provision of this Agreement becomes or is declared
by a court of competent jurisdiction to be illegal, unenforceable or void, this Agreement shall

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continue in full force and effect without said provision; provided that, if the severance of
such provision materially changes the economic benefits of this Agreement to either party as such
benefits are anticipated as of the date hereof, then such party may terminate this Agreement on
five (5) business days prior written notice to the other party. In such event, the Registration
Rights Agreement will terminate simultaneously with the termination of this Agreement; provided
that in the event that this Agreement is terminated by the Company in accordance with this Section
10.8 and the Warrant Shares either have not been registered for resale by the Investor in
accordance with the Registration Rights Agreement or are otherwise not freely tradable (if and when
issued) in accordance with applicable law, then the Registration Rights Agreement in respect of the
registration of the Warrant Shares shall remain in full force and effect.

     Section 10.9 Title and Subtitles. The titles and subtitles used in this Agreement are
used for the convenience of reference and are not to be considered in construing or interpreting
this Agreement.

     Section 10.10 Counterparts. This Agreement may be executed in multiple counterparts,
each of which may be executed by less than all of the parties and shall be deemed to be an original
instrument which shall be enforceable against the parties actually executing such counterparts and
all of which together shall constitute one and the same instrument.

     Section 10.11 Choice of Law. This Agreement shall be construed under the laws of the
State of New York.

     Section 10.12 Specific Enforcement, Consent to Jurisdiction.

               (a) The Company and the Investor acknowledge and agree that irreparable damage would occur in
the event that any of the provisions of this Agreement were not performed in accordance with their
specific terms or were otherwise breached. It is accordingly agreed that either party shall be
entitled to an injunction or injunctions to prevent or cure breaches of the provisions of this
Agreement by the other party and to enforce specifically the terms and provisions hereof or
thereof, this being in addition to any other remedy to which either party may be entitled by law or
equity.

               (b) Each of the Company and the Investor (i) hereby irrevocably submits to the jurisdiction of
the United States District Court and other courts of the United States sitting in the State of New
York for the purposes of any suit, action or proceeding arising out of or relating to this
Agreement and (ii) hereby waives, and agrees not to assert in any such suit, action or proceeding,
any claim that it is not personally subject to the jurisdiction of such court, that the suit,
action or proceeding is brought in an inconvenient forum or that the venue of the suit, action or
proceeding is improper. Each of the Company and the Investor consents to process being served in
any such suit, action or proceeding by mailing a copy thereof to such party at the address in
effect for notices to it under this Agreement and agrees that such service shall constitute good
and sufficient service of process and notice thereof. Nothing in this Section 10.12 shall affect
or limit any right to serve process in any other manner permitted by law.

-28-

 

     Section 10.13 Survival. The representations and warranties of the Company and the
Investor contained in Articles IV and V and the covenants contained in Article V and Article VI
shall survive the execution and delivery hereof and the Closing until the termination of this
Agreement, and the agreements and covenants set forth in Article VIII and Article IX of this
Agreement shall survive the execution and delivery hereof and the Closing hereunder.

     Section 10.14 Publicity. Except as otherwise required by applicable law or
regulation, or NASDAQ rule or judicial process, prior to the Closing, neither the Company nor the
Investor shall issue any press release or otherwise make any public statement or announcement with
respect to this Agreement or the transactions contemplated hereby or the existence of this
Agreement. In the event the Company is required by law, regulation, NASDAQ rule or judicial
process, based upon reasonable advice of the Company’s counsel, to issue a press release or
otherwise make a public statement or announcement with respect to this Agreement prior to the
Closing, the Company shall consult with the Investor on the form and substance of such press
release, statement or announcement. Promptly after the Closing, each party may issue a press
release or otherwise make a public statement or announcement with respect to this Agreement or the
transactions contemplated hereby or the existence of this Agreement; provided that, prior to
issuing any such press release, making any such public statement or announcement, the party wishing
to make such release, statement or announcement consults and cooperates in good faith with the
other party in order to formulate such press release, public statement or announcement in form and
substance reasonably acceptable to both parties.

     Section 10.15 Further Assurances. From and after the date of this Agreement, upon the
request of the Investor or the Company, each of the Company and the Investor shall execute and
deliver such instruments, documents and other writings as may be reasonably necessary or desirable
to confirm and carry out and to effectuate fully the intent and purposes of this Agreement.

[Remainder of this page intentionally left blank.]

-29-

 

     IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed by their
respective authorized officer as of the date first written.

	 	 	 	 	 
	 	KINGSBRIDGE CAPITAL LIMITED

 	 
	 	By:  	      /s/ Adam Gurney
 	 
	 	 	Adam Gurney

Managing Director 	 
	 
	 	OXiGENE INC.

 	 
	 	By:  	     /s/ James B. Murphy
 	 
	 	 	James B. Murphy 	 
	 	 	Vice President and Chief Financial Officer 	 
	 

-30-

 

Exhibit A

Form of Registration Rights Agreement

 

 

Exhibit B

Form of Warrant

 

 

Exhibit C

Form of Draw Down Notice

Kingsbridge Capital Limited

Attention: Mr. Tony Hillman

P.O. Box 1075

Elizabeth House

9 Castle Street

St. Helier

Jersey

JE42QP

Channel Islands

Facsimile: 011-44-1534-636-042

Email: admin@kingsbridgecap.com; and adamgurney@kingsbridgecap.com

Kingsbridge Corporate Services Limited

Kingsbridge House

New Abbey

Kilcullen, County Kildare

Republic of Ireland

Facsimile: 011-353-45-482-003

Email: adamgurney@kingsbridge.ie; and pwhelan@kingsbridge.ie

Stroock & Stroock & Lavan LLP

180 Maiden Lane

New York, NY 10038

Facsimile: (212) 806-5400

Attention: Keith M. Andruschak, Esq. – kandruschak@stroock.com

Reference is hereby made to that certain Common Stock Purchase Agreement dated as of February 19,
2008 (the “Agreement”) by and between OXiGENE, Inc., a corporation organized and existing under the
laws of the State of Delaware (the “Company”), and Kingsbridge Capital Limited, an entity organized
and existing under the laws of the British Virgin Islands (the “Investor”). Capitalized terms used
and not otherwise defined herein shall have the meanings given such terms in the Agreement.

In accordance with and pursuant to Section 3.1 of the Agreement, the Company hereby issues this
Draw Down Notice to the Investor pursuant to the terms set forth below.

Draw Down Amount: $                     ; and

First
Trading Day of Draw Down Pricing Period:                      , 200[_].

Enclosed with this Draw Down Notice is an executed copy of the Officer’s Certificate described in
Section 3.1 of the Agreement, the base form of which is attached to such Agreement as Exhibit D.

 

 

Exhibit D

Officer’s Certificate

     I, [NAME OF OFFICER], do hereby certify to Kingsbridge Capital Limited (the
“Investor”), with respect to the common stock of OXiGENE, Inc. (the “Company”)
issuable in connection with the Draw Down Notice, dated                      (the “Notice”)
attached hereto and delivered pursuant to Article III of the Common Stock Purchase Agreement, dated
February 19, 2008 (the “Agreement”), by and between the Company and the Investor, as
follows (capitalized terms used but undefined herein have the meanings given to such terms in the
Agreement):

     1. I am the duly elected [OFFICER] of the Company.

     2. The representations and warranties of the Company set forth in Article IV of the Agreement
are true and correct in all material respects as though made on and as of the date hereof (except
for such representations and warranties that are made as of a particular date).

     3. The Company has performed in all material respects all covenants and agreements to be
performed by the Company on or prior to the date hereof related to the Notice and has satisfied
each of the conditions to the obligation of the Investor set forth in Article VII of the Agreement.

     4. The Shares issuable in respect of the Notice will be delivered without restrictive legend
via book entry through the Depositary Trust Company to an account designated by the Investor.

     The
undersigned has executed this Certificate this ___ day of, 200[_].

	 	 	 	 	 
	 

	 	Name:	 	 
	 

	 	 	 	 
	 

	 	Title:exv10w1

 

Exhibit 10.1

IONA TECHNOLOGIES PLC

SENIOR MANAGEMENT TEAM BONUS PLAN

1. Purpose

     This Senior Management Team Bonus Plan (the “Bonus Plan”) is intended to provide an incentive
for superior work and to motivate eligible members of the senior management team of IONA
Technologies PLC (the “Company”) and its subsidiaries toward high achievement and business results,
to tie their goals and interests to those of the Company and its shareholders and to enable the
Company to attract and retain highly qualified executives. The Bonus Plan is for the benefit of
Covered SMT Members (as defined below).

2. Covered SMT Members

     From time to time, the Compensation Committee of the Board of Directors of the Company (the
“Compensation Committee”) may select certain key members of the senior management team who have
been employed by the Company or one of its subsidiaries on a
full-time basis for not less than three
months (the “Covered SMT Members”) to be eligible to receive bonuses hereunder. Generally, in order
to be eligible to be selected to receive a bonus under the Bonus Plan, Covered SMT Members must
have been employed by the Company or one of its subsidiaries on a full-time basis for not less than
three months during the relevant performance period provided, however, that the Compensation
Committee may make exceptions to this requirement, in its sole discretion, based on individual
circumstances.

3. Administration

     The Compensation Committee shall have the sole discretion and authority to administer and
interpret the Bonus Plan.

4. Bonus Determinations

     (a) A Covered SMT Member may receive a bonus payment under the Bonus Plan based upon the
attainment of performance targets which are established by the Compensation Committee and relate to
financial and operational metrics with respect to the Company or any of its subsidiaries (the
“Performance Goals”), including but without limitation the following: earnings per share,
revenues, operating income, billings, expenses and EBITDA.

     (b) Except as otherwise set forth in this Section 4(b): (i) any bonuses paid to Covered SMT
Members under the Bonus Plan shall be based upon objectively determinable bonus formulas that tie
such bonuses to one or more performance targets relating to the Performance Goals, (ii) bonus
formulas for Covered SMT Members shall be adopted in each performance period by the Compensation
Committee and communicated to each Covered SMT Member at the beginning of each performance period
(provided however that if a member of the senior management team becomes a Covered SMT Member after
the beginning of a performance period, the bonus formulas shall be communicated to that Covered SMT
Member as soon as reasonably practicable) and (iii) no bonuses shall be paid to Covered SMT Members
unless and until the Compensation Committee makes a determination with respect to the attainment
of the performance objectives. Notwithstanding the foregoing, the Compensation Committee may
adjust bonuses payable under the Bonus Plan based on achievement of individual performance goals or
pay bonuses (including, without limitation, discretionary bonuses) to Covered SMT Members under the
Bonus Plan based upon such other terms and conditions as the Compensation Committee may in its
discretion determine.

     (c) Each Covered SMT Member shall have a targeted bonus opportunity for each performance
period. The bonus payable to a Covered SMT Member may exceed the targeted bonus opportunity if the
Performance Goals are exceeded. A member of the senior management team who becomes a Covered SMT
Member after the beginning of a performance period, shall be entitled to a bonus payment calculated
on a pro-rata basis based upon the period of time during the performance period that such
individual is a Covered SMT Member.

 

 

     (d) The payment of a bonus to a Covered SMT Member with respect to a performance period shall
be conditioned upon the Covered SMT Member being (i) a full-time employee of the Company or any of
its subsidiaries and in attendance at work (excluding permitted leave) throughout the performance
period (except in the case of a member of the senior management team becoming a Covered SMT Member
after the beginning of a performance period) and (ii) a full-time employee of the Company or any of
its subsidiaries on the day the bonus payments are made ; provided, however, that the Compensation
Committee may make exceptions to these requirements, in its sole discretion, including, without
limitation, in the case of a Covered SMT Member’s termination of employment, retirement, death or
disability.

5. Timing of Payment

     The Performance Goals will be measured at the end of each fiscal year after the Company’s
financial reports have been published. If the Performance Goals are met, payments will be made
within sixty (60) days thereafter, but not later than March 15.

6. Amendment and Termination

     The Company reserves the right to amend or terminate the Bonus Plan at any time in its sole
discretion.

2

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