Document:

<PAGE>
                                                                  EXHIBIT 10.4

         THIS AGREEMENT ("Agreement") is dated as of August 21, 2001, by and
between CONNETICS CORPORATION, a Delaware corporation, whose address for notice
purposes is 3290 West Bayshore Road, Palo Alto, California 94303 (herein
"CONNETICS"), and RESPOND.COM, INC., a Delaware corporation, whose address for
notice purposes is 3294 West Bayshore Road, Palo Alto, California 94303 (herein
"RESPOND.COM"). Connetics and Respond.com are sometimes referred to individually
in this Agreement as a "Party", and collectively as the "Parties".

                                    RECITALS

     A.   Respond.com, as assignor, and Connetics, as assignee, have entered
          into that certain Assignment and Assumption of Lease dated as of the
          date hereof (the "Assignment"), a copy of which is attached hereto as
          Exhibit A and made a part hereof, with respect to those certain
          premises located at 3290 West Bayshore Road, Palo Alto, CA 94303, as
          more fully described in the Assignment (the "3290 Premises").

     B.   Connetics, as sublessor, and Respond.com, as sublessee, have also
          entered into that certain Sublease dated as of the date hereof (the
          "3290 Sublease") with respect to a portion of the 3290 Premises, a
          copy of which is attached as Exhibit B hereto and made a part hereof.

     C.   Connetics, as sublessor, and Respond.com, as sublessee, have also
          entered into that certain Sublease dated as of the date hereof (the
          "3294 Sublease"), a copy of which is attached as Exhibit C hereto and
          made a part hereof, with respect to a portion of the premises located
          at 3294 West Bayshore Avenue, Palo Alto, California, which premises
          are located adjacent to the 3290 Premises.

     D.   The Parties have agreed to terms supplemental to the Assignment, the
          3290 Sublease and the 3294 Sublease, as set forth herein. The Parties
          agree that the Assignment, the 3290 Sublease, the 3294 Sublease and
          the Non-Disclosure Agreement referenced in Section 6 hereof constitute
          the entire agreement between the Parties with regard to the real
          property located at 3290 and 3294 West Bayshore Avenue, Palo Alto,
          California.

     THEREFORE, the Parties agree as follows:

1.  PREMIUM

Throughout the term of the 3294 Sublease, Respond.com shall pay to Connetics an
additional sum ("Premium") as follows: (i) $14,914.75 per month from the
Commencement Date of the 3294 Sublease until April 30, 2002, and (ii) $15,914.75
per month from May 1, 2002 until January 31, 2003. The Premium shall be payable
on the

<PAGE>

same date as the monthly rental specified in the 3294 Sublease, and prorated for
any partial month as specified in Section 3 of the 3294 Sublease. Upon the
termination or earlier expiration of the 3294 Sublease, Respond.com shall have
no further obligation to pay any portion of the Premium. In the event that
Respond.com assigns the 3294 Sublease (which assignment shall be subject to the
terms and conditions set forth in the 3294 Sublease), Connetics shall have the
right to condition its consent to the assignment to an agreement by the
potential assignee to also assume Respond.com's obligations under this
Agreement.

2.   FURNITURE TO BE TRANSFERRED TO RESPOND.COM

On or before the Commencement Date of the 3294 Sublease, Connetics and
Respond.com shall enter into a bill of sale with respect to the furniture to be
transferred from Connetics to Respond.com, the form of which is attached hereto
as Exhibit D and made a part hereof.

3.   FURNITURE TO BE TRANSFERRED TO CONNETICS

Upon the Effective Date of the Assignment, Connetics and Respond.com shall enter
into a bill of sale with respect to the furniture to be transferred from
Respond.com to Connetics, the form of which is attached hereto as Exhibit E and
made a part hereof.

4.   ASSIGNMENT

Either Party may assign its respective interest under this Agreement by
obtaining the prior written consent of the other Party, which consent shall not
be unreasonably withheld. Any such assignment will not release the assigning
Party of any and all liability accruing to that Party prior to the effective
date of such assignment.

5.   TERMINATION

5.1  TERMINATION BY RESPOND.COM

Respond.com is entitled by written notice to Connetics to terminate this
Agreement upon the happening of any of the following events:

     (i)     the termination of the 3294 Sublease;

     (ii)    the failure of Connetics to rectify any material breach or
             non-observance of any of the terms and conditions contained in
             this Agreement within thirty (30) days after Respond.com gives
             written notice to Connetics specifying such breach or
             non-observance and requiring that it be rectified;

     (iii)   a petition or other application being presented or resolution
             being passed for the winding up, liquidation or dissolution of
             Connetics;

                                       2
<PAGE>

     (iv)    the appointment of a receiver or receiver and manager or official
             manager or agent of a creditor of Connetics;

     (v)     Connetics ceasing to carry on business or stopping or wrongfully
             suspending payment of any of its creditors or stating an intention
             to do so.

5.2  TERMINATION BY CONNETICS

Connetics is entitled by written notice to Respond.com to terminate this
Agreement upon the happening of any of the following events:

     (i)     the termination of the 3294 Sublease;

     (ii)    the failure of Respond.com to rectify any material breach or
             non-observance of any of the terms and conditions contained in this
             Agreement within thirty (30) days after Connetics gives written
             notice to Respond.com specifying such breach or non-observance and
             requiring it to be rectified;

     (iii)   a petition or other application being presented or resolution
             being passed for the winding up, liquidation or dissolution of
             Respond.com or notice of intention to propose such a resolution
             being given or the entry of Respond.com into a scheme of
             arrangement or compromise with any of its creditors;

     (iv)    the appointment of a receiver or receiver and manager or
             official manager or agent of a creditor of Respond.com;

     (v)     Respond.com ceasing to carry on business or stopping or
             wrongfully suspending payment of any of its creditors or stating
             an intention to do so.

16.  CONFIDENTIALITY

The Parties acknowledge that the terms of this Agreement and all discussions and
correspondence in connection therewith is confidential and the terms of this
Agreement and such discussions and correspondence shall not in any way be
disclosed to any third party except in connection with a proposed assignment of
this Agreement or with the prior written consent of the non-disclosing Party and
each Party will take every reasonable precaution to protect the confidentiality
of such information and with no less restrictive precautions than it takes to
protect its own confidential information.

The parties acknowledge and agree to continue to abide by the terms of a Mutual
Nondisclosure Agreement entered into between the Parties on June 29, 2001, a
copy of which is attached as Exhibit F hereto, and agree that the terms hereof
are not in any way intended to amend, supersede or circumvent the terms of said
agreement.

                                       3
<PAGE>

7.   NOTICES

Any notices or demands which may or are required to be given by either Party to
the other hereunder shall be in writing. All notices and demands shall be
sufficient if delivered in person, by receipted courier service, or sent by
United States Mail, postage pre-paid. Any such notice is effective at the time
of delivery or of mailed, two (2) business days after mailing. For purposes of
this Agreement, the Parties' contact information is as follows:

     (a) If to Connetics, then to: Christopher T. Holman
                                   Director, Facilities and Production Planning
                                   Connetics Corporation
                                   3294 West Bayshore RD.
                                   Palo Alto, CA  94303

                                   Tel: 650-843-2807
                                   Fax: 650-843-2898

     (b)  If to Respond.com, to:   Respond.com, Inc.
                                   3290 West Bayshore Road
                                   Palo Alto, CA 94303
                                   Tel: 650-461-1000
                                   Fax: 650-461-1892
                                   Attn:  Chief Executive Officer

                                   With a copy to:
                                   Wilson Sonsini Goodrich & Rosati
                                   650 Page Mill Road
                                   Palo Alto, CA 94304-1050
                                   Tel: 650-493-9300
                                   Fax: 650-493-6811
                                   Attn:  Stephen Bochner

8. SEVERANCE

If any provision of this Agreement is held to be invalid, illegal or
unenforceable by a court of competent jurisdiction, then: (a) such provision
will be deemed amended to conform to applicable laws of such jurisdiction so as
to be valid and enforceable, or, if it cannot be so amended without materially
altering the intention of the Parties, it will be stricken; (b) the remaining
provisions of this Agreement will remain in full force and effect.

9. WAIVER

                                       4
<PAGE>

No term or condition of this Agreement is considered waived unless reduced to
writing and duly executed by an officer of the waiving Party.

10. PROPER LAW

This Agreement is governed by the laws of the State of California and any
disputes hereunder shall be subject to the exclusive jurisdiction of the State
of California.

11. ENTIRE AGREEMENT

This Agreement sets forth the entire agreement of the Parties with regard to the
subject matter herein and, except as otherwise stated herein, supersedes all
other agreements between the Parties relating to the subject matter hereof.

                                       5
<PAGE>

IN WITNESS WHEREOF, the Parties have entered into this Agreement as of the date
first specified above.

CONNETICS CORPORATION,                      Respond.com, Inc.,
a Delaware corporation                      a Delaware corporation

________________________________            By:  ___________________________
John L. Higgins
Executive Vice President, Finance &         Name: __________________________
Administration, CFO
                                            Its: ___________________________

                                       6
<PAGE>
                                    EXHIBIT A

                                   ASSIGNMENT

                                       7
<PAGE>
                                    EXHIBIT B

                                  3290 SUBLEASE

                                       8
<PAGE>
                                    EXHIBIT C

                                  3294 SUBLEASE

                                       9
<PAGE>

                                   EXHIBIT D

                                  BILL OF SALE

                              (CONNETICS FURNITURE)

         For the sum of One Dollar ($1) representing good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged,
Connetics Corporation ("Seller") hereby bargains, sells, assigns, transfers and
delivers to Respond.com, Inc. ("Purchaser") all of Seller's right, title and
interest in and to the property described on the attached Exhibit A (the
"Property").

         Seller hereby represents and warrants to Purchaser that (a) Seller is
the absolute owner of the Property, (b) the Property is free and clear of all
liens, charges and encumbrances and (c) Seller has full right, power and
authority to sell the Property and to execute and deliver this Bill of Sale.
Seller will defend, indemnify, and hold Purchaser harmless from all claims or
causes of action alleging claims to the contrary. The Property is delivered and
sold in its present condition "AS IS," and ALL WARRANTIES OF QUALITY, FITNESS
AND MERCHANTABLITY ARE HEREBY EXCLUDED.

         TO HAVE AND TO HOLD all and singular the Property unto Purchaser, its
successors, heirs, executors, administrators and assigns to their own proper use
and benefit, forever.

         IN WITNESS WHEREOF, this Bill of Sale has been executed as of
__________, 2001.

                                       SELLER:
                                       Connetics Corporation,
                                       a Delaware Corporation

                                       By:
                                          --------------------------------------
                                       Name: John Higgins
                                       Its: Chief Financial Officer

                                       PURCHASER:
                                       Respond.com, Inc.,
                                       a Delaware Corporation

                                       By:
                                          --------------------------------------
                                       Name: Dana C. Stalder
                                       Its: Chief Financial Officer

                                       10
<PAGE>
                                    EXHIBIT A

                  ASSETS TRANSFERRED FROM CONNETICS CORPORATION
                              TO RESPOND.COM, INC.

<TABLE>
<CAPTION>
COUNT     DESCRIPTION
-----     -----------
<S>       <C>
  11      8' X 8' blue cubicles
          (Includes walls, desktops, 19 double sectioned
          overhead cabinets, taks lights, 10 three drawer
          pedstal, 14 two drawer pedistals.)

   3      8" X 12" blue cubicles
          (Includes walls, desktops, 3 double sectioned
          overhead cabinets, 3 single sectioned cabinets, taks
          lights, 3 three drawer pedstal, 2 two drawer
          pedistals.)

   1      Credenza
   1      48" X 12" Table (Conference Room Table)
  18      Gray United Conference Room Chairs

  28      Purple Side Chairs
  23      Plum Side Chaairs
  19      Blackberry Side Chairs

   6      30" X 60" Lunch room tables

  26      Gray 7' X 9" cubicles
          (Includes walls, desktops, 11 double sectioned overhead
          cabinets, 28 single overhead cabinets, taks lights,
          23 three drawer pedstal, 23 two drawer pedistals, &
          15 metal shelves.)

   1      48" Round table

   2      3' X 8' table

   1      29" X 8' table
</TABLE>

                                       11
<PAGE>

<TABLE>
<S>       <C>
   8      36" Round Tables

  60      Gray United Swivel Ergo chairs

  27      Gray United Sled based Chairs

   4      Dark Gray Office Master Swivel Ergo Chairs

   1      Gray Chair

   2      Red Stool Chair

   1      Black stool Chair

   3      Green Swivel Office Master Ergo chairs

   1      Teal Swivel Office master Ergo chairs

   1      United Swivel Ergo Chairs

  13      Stylex Swivel ergo Chairs (Mixed colors)

   8      Stylex Sled Based Chairs (Mixed Colors)

          Hard Wall Offices
          ( Includes 28 two drawer pedistals, 27 three drawer
          pedistals, 6 metal shelves, 15 wall mounted task
          boards, 43 overhead cabinets, desktops & frames,
          tasklights)

   2      Refrigerators

   3      Printer Stands

   1      Printer Table

   1      Phone Stand

   1      TV Cabinet

   1      3' X 8' Table

   2      Large open shelves

   1      Printer Stand
</TABLE>

                                       12
<PAGE>
<TABLE>
<S>       <C>
   1      Mail sorting Shelves

   1      Workstation

   2      refrigerators

   3      printer stands

   1      printer table

   1      phone stand

   1      TV cabinet

   1      3 x 8 table

   2      large open shelving

   1      printer stand

   1      mail sorting shelves

   1      workstation from storage room

   All    attached white boards
</TABLE>

                                       13

<PAGE>
                                    EXHIBIT E

                                  BILL OF SALE

                             (RESPOND.COM FURNITURE)

         For the sum of One Dollar ($1) representing good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged,
Respond.com, Inc. ("Seller") hereby bargains, sells, assigns, transfers and
delivers to Connetics Corporation ("Purchaser") all of Seller's right, title and
interest in and to the property described on the attached Exhibit A (the
"Property").

         Seller hereby represents and warrants to Purchaser that (a) Seller is
the absolute owner of the Property, (b) the Property is free and clear of all
liens, charges and encumbrances and (c) Seller has full right, power and
authority to sell the Property and to execute and deliver this Bill of Sale.
Seller will defend, indemnify, and hold Purchaser harmless from all claims or
causes of action alleging claims to the contrary. The Property is delivered and
sold in its present condition "AS IS," and ALL WARRANTIES OF QUALITY, FITNESS
AND MERCHANTABLITY ARE HEREBY EXCLUDED.

         TO HAVE AND TO HOLD all and singular the Property unto Purchaser, its
successors, heirs, executors, administrators and assigns to their own proper use
and benefit, forever.

         IN WITNESS WHEREOF, this Bill of Sale has been executed as of
__________, 2001.

                                   SELLER:
                                   Respond.com, Inc.,
                                   a Delaware Corporation

                                   By:
                                      ------------------------------------------
                                   Name: Dana C. Stalder
                                   Its: Chief Financial Officer

                                   PURCHASER:
                                   Connetics Corporation,
                                   a Delaware Corporation

                                   By:
                                      ------------------------------------------
                                   Name: John Higgins
                                   Its: Chief Financial Officer

                                       14
<PAGE>
                            EXHIBIT A TO BILL OF SALE

                    ASSETS TRANSFERRED FROM RESPOND.COM, INC.

                            TO CONNETICS CORPORATION

<TABLE>
<CAPTION>
COUNT     DESCRIPTION
-----     -----------
<S>       <C>
 49       Desk Chairs - Blue
  2       48" Round Conference Tables
  1       10" Oval Conference Table
  2       Whiteboards
 28       Hon Pagoda Stack Chairs
  8       Chrome Shelving
  3       Printer Stands
  2       Grey Tables
 25       Keyboard Trays
145       Cubes
  1       Cubes (partial)
114       Desk Chairs - Green
  2       48" Round Conference Table
  1       Oval Conference Table (72x42x29)
 18       Boardroom Chairs
  4       Cabinet-Storage
  6       Counters   Kitchen
  5       Lunchroom Tables
 10       Lunchroom Chairs
  1       Prizmatic Rect. Table w/110v (Board Room)
  1       Office desk and File Cabinet
  4       Leather Chairs
  1       Refrigerator - Black
  1       DSS Satellite Dish
</TABLE>

                                       15
<PAGE>
                                    EXHIBIT F
                         MUTUAL NONDISCLOSURE AGREEMENT
                                [TO BE ATTACHED]

                                       16<PAGE>

                                                                EXHIBIT 10.5

                                    SUBLEASE

                           (3290 West Bayshore Avenue)

        This sublease ("Sublease") is executed this 21st day of August, 2001, by
and between Connetics Corporation, a Delaware corporation (the "Sublessor"), and
Respond.com, Inc., a Delaware corporation (the "Sublessee").

                                    RECITALS

        A. West Bayshore Associates, a general partnership, Sigrid S. Banks,
Frank Lee Crist, Jr., Allen W. Koering and George O. McKee, as landlord
(collectively, "Lessor"), and Sublessee, as tenant, executed a lease dated
November 20, 1998 (the "Master Lease") with respect to approximately 28,968
rentable square feet of the building located at 3290 West Bayshore Avenue, Palo
Alto, California, as such premises are more fully described in the Master Lease
("Master Premises") which is attached as Exhibit A hereto and made a part
hereof;

        B. Pursuant to that certain Assignment of Lease dated as of the date
hereof by and between Sublessee, as assignor, and Sublessor, as assignee (the
"Assignment") attached as Exhibit B hereto and made a part hereof, Sublessor is
the successor in interest to Sublessee's interest as tenant under the Master
Lease;

        C. Pursuant to that certain Sublease dated as of the date hereof by and
between Sublessor, as sublessor, and Sublessee, as sublessee, (the "3294
Sublease") attached as Exhibit C hereto and made a part hereof, Sublessee will
be subleasing from Sublessor a portion of the premises located at 3294 West
Bayshore Avenue, Palo Alto (the "3294 Premises"), which premises are adjacent to
the Master Premises, all upon the terms and conditions set forth in the 3294
Sublease;

        D. Sublessor desires to sublease to Sublessee a portion of the Master
Premises, and Sublessee desires to lease a portion of the Master Premises from
Sublessor, subject to the terms and conditions of this Sublease; and,

        E. Capitalized terms used but not defined herein shall have the meaning
ascribed to them in the Master Lease.

        THEREFORE, Sublessor and Sublessee agree as follows:

                       LEASING AND DESCRIPTION OF PROPERTY

        1. Subject to the terms, conditions, and covenants set forth in this
Sublease, Sublessor hereby subleases to Sublessee, and Sublessee hereby
subleases from Sublessor, approximately 21,000 square feet of the Master
Premises, as shown as cross-hatched on Exhibit D attached hereto and made a part
hereof (the "Subleased Premises").

                                      TERM

                                       1
<PAGE>

        2. The term of this Sublease shall commence on the Effective Date (as
defined in Section 1 of the Assignment) (the "Commencement Date"), and shall
terminate on the later to occur of (i) October 22, 2001 or (ii) the Commencement
Date of the 3294 Sublease. Notwithstanding any provision of this Sublease to the
contrary, if Sublessor has not delivered the 3294 Premises to Sublessee by
December 1, 2001 for any reason, then Sublessee shall have the right to
terminate this Sublease and upon receipt of such notice this Sublease shall
terminate and Sublessor shall promptly thereafter return to Sublessee all sums
previously paid or deposited by Sublessee hereunder.

                                      RENT

        3. Sublessee shall pay to Sublessor as rent for the Subleased Premises a
rental of Ninety One Thousand Six Hundred Eighty Three and 72/100 dollars
($91,683.72) per month payable in advance on the first day of each calendar
month during the term, commencing on the Commencement Date. Rent shall be paid
to Sublessor at 3290 West Bayshore, Palo Alto, CA, or at any other place
designated in writing by Sublessor. The installment rent payable for any portion
of a calendar month shall be a pro rata portion of the installment payable for a
full calendar month. Sublessee agrees that the payable monthly rental amount
does not include any liability of Sublessor for Sublessee's prorated share of
real property taxes and assessments (general and special), insurance,
maintenance, Landlord management fee and such other costs and fees which are the
responsibility of the Sublessor under Section 6(b) of the Master Lease, which
amounts are invoiced separately by Lessor. Notwithstanding the foregoing, from
and after October 22, 2001, the rent hereunder shall be reduced to Twenty Seven
Thousand Six Hundred Ninety Eight and 81/100 dollars ($27,698.81) per month.

                                SECURITY DEPOSIT

        4. Sublessee has previously deposited with Sublessor the total sum of
Three Hundred Four Thousand Nine Hundred Ninety Six and 16/100 dollars
($304,996.16) as a security deposit (the "Security Deposit"). If Sublessee
defaults with respect to any provision of this Sublease, including, but not
limited to, the provisions relating to rent, Sublessor may (but shall not be
required to) use or apply all or any part of the Security Deposit for the
payment of rent or any other sum in default hereunder. If any portion of the
Security Deposit is so used or applied, Sublessee shall, within (5) days after
written demand therefore, deposit cash with Sublessor in an amount sufficient to
restore the Security Deposit to its original amount. Upon the Commencement Date
of the 3294 Sublease, the Security Deposit, or so much thereof which has not
been used or applied by Sublessor pursuant to this Section 4, shall be deemed to
be the security deposit required under the 3294 Sublease and shall be held by
Sublessor pursuant to the terms and conditions of the 3294 Sublease.
Notwithstanding the

                                       2
<PAGE>

foregoing, if this Sublease terminates or expires prior to the Commencement Date
of the 3294 Sublease, or if the 3294 Sublease is terminated prior to the
Commencement Date thereof, then the Security Deposit, or so much thereof as has
not theretofore been applied by Sublessor, shall be returned to Sublessee
promptly following the expiration or earlier termination of this Sublease, not
to exceed ten (10) days after such termination or expiration.

                               ACCESS BY SUBLESSOR

        5. During the term hereof, Sublessor shall restrict its access to and
from that portion of the Master Premises which is not the Subleased Premises
(the "Sublessor's Premises") to the two (2) entrances located on the north side
of the building, as depicted on Exhibit D. During the construction of the
contemplated tenant improvements Sublessor intends to make within Sublessor's
Premises (the "Tenant Improvements"), only Authorized Personnel of Sublessor
shall have access to the Sublessor's Premises. "Authorized Personnel" as used in
this Section 5 shall mean those employees, contractors, agents and suppliers of
Sublessor who have been approved in writing by Sublessee and require access in
order to complete the Tenant Improvements. The parties hereby acknowledge and
agree that although the Subleased Premises will not be separately demised from
Sublessor's Premises by a permanent interior wall, Sublessor will be installing
a physical barrier between such premises as specified below, and each party
hereto hereby agrees to prevent its employees, agents, assigns and contractors
from entering into the premises of the other. In addition, the parties hereby
agree as follows:

        (i)     Prior to the commencement of any physical work associated with
                the Tenant Improvements, Sublessor shall install, to the
                satisfaction of Sublessee, physical barriers between the
                Sublessor's Premises and the Subleased Premises which shall
                designate the respective boundaries of each in the approximate
                locations shown on Exhibit D, and which shall minimize noise,
                dust and any disruption to Sublessee's operations;

        (ii)    Prior to commencing any physical work associated with the Tenant
                Improvements which could result in dust infiltration in the
                ventilation system and areas outside the Sublessor's Premises,
                Sublessor shall install, to the satisfaction of the Sublessee,
                dust filters and other required barriers to minimize dust
                infiltration into the ventilation system and areas outside the
                Sublessor's Premises;

        (iii)   Sublessor shall provide not less than seventy two (72) hours'
                written notice of any work that could impact the ordinary course
                of business for Sublessee including, but not limited to, power
                outages, parking restrictions, painting or chemical fumes and
                high audible construction. Such work which is

                                       3
<PAGE>

                determined by Sublessee to have a material impact on Sublessee's
                business operations will be scheduled on evenings and weekends;

        (iv)    Sublessor and its Authorized Personnel shall have no right to
                use the kitchen or restroom facilities within the Subleased
                Premises during the term hereof. Sublessor shall provide its own
                temporary restroom and sanitary facilities during the term
                hereof.

        Sublessor hereby agrees that it shall indemnify, defend, protect and
hold harmless Sublessee from and against any and all claims or liability for any
injury or damage to any person or property, including any reasonable attorneys'
fees, occurring in, on or about the Subleased Premises or the Sublessor's
Premises to the extent such injury or damages is caused by its, or its
employees', agents' or contractors' negligence or willful misconduct

                                 QUIET ENJOYMENT

        6. Sublessor covenants that Sublessee shall be entitled to quiet
enjoyment of the Subleased Premises, provided that Sublessee complies with the
terms of this Sublease.

                              CONDITION OF PREMISES

        7. Sublessee agrees that Sublessee's act of taking possession will be an
acknowledgment that the Subleased Premises are in a tenantable condition.
Sublessee shall maintain the Subleased Premises in accordance with the terms and
conditions of the Master Lease, as incorporated below. Notwithstanding the
foregoing, it is hereby acknowledged and agreed that Sublessee shall have no
obligation to remove any portion of the tenant improvements, alterations or
additions within the Subleased Premises upon the expiration or earlier
termination of this Sublease, it being expressly understood and agreed that
Sublessor has assumed all of Sublessee's rights and obligations as tenant under
the Master Lease, pursuant to the terms of the Assignment. Sublessee shall have
the right to leave all such tenant improvements, alterations and additions in
their current "as is" condition upon the expiration or earlier termination of
this Sublease; provided, however, that Sublessee shall remove the single
exterior sign which is currently located on the exterior of the building near
the main entrance.

                          APPLICABILITY OF MASTER LEASE

        8. Except as otherwise provided in this Sublease, all of the terms and
provisions of the Master Lease are incorporated into and made a part of this
Sublease, and the rights and obligations under the Master Lease are hereby
imposed upon the parties hereto with respect

                                       4
<PAGE>

to the Subleased Premises, the Sublessor being substituted for the Lessor or
Landlord in the Master Lease and the Sublessee being substituted for the Tenant
in the Master Lease and the Subleased Premises being substituted for the
Premises in the Master Lease; provided, however, that the term "Landlord" in the
following sections of the Master Lease shall mean (i) Lessor, not Sublessor: 11,
12, 13, 17(b), 21, 22, 25, and 32; and (ii) both Lessor and Sublessor: 15, 16,
and 31. Notwithstanding the foregoing, the following sections of the Master
Lease are not incorporated herein: 8 and 33. In the event of any conflict
between the terms of this Sublease and the Master Lease, the terms and
conditions of this Sublease shall control.

               SUBLESSEE'S RIGHTS REGARDING CONTINUING POSSESSION

        9. Sublessee shall have the right at any time, at Sublessor's expense,
to take any action required to be taken, but not timely taken, by Sublessor,
that may be necessary to prevent a default under the terms of the Master Lease.
Nothing contained in this sublease shall be construed so as to deprive Sublessee
of Sublessee's right to surrender or otherwise terminate this Sublease as
provided by law.

                            OBLIGATIONS OF SUBLESSOR

        10. Sublessor agrees to maintain the Master Lease during the entire term
of this Sublease, subject, however, to any earlier termination of the Master
Lease without the fault of Sublessor. Sublessor also agrees to pay all rentals
and taxes as provided for in the Master Lease in accordance with its terms, and
to comply with or perform all obligations under the Master Lease that Sublessee
has not assumed under this Sublease. Further, Sublessor agrees not to modify or
surrender the Master Lease without the prior written consent of Sublessee, which
Sublessee may withhold in its sole discretion. Any modification or surrender
made without that consent shall be null and void and shall have no effect on the
rights of Sublessee under this Sublease. Except as otherwise set forth herein,
Sublessor does not assume the obligations required to be kept or performed by
the Lessor under the Master Lease.

                                    INSURANCE

        11. Sublessee shall maintain during the term hereof commercial general
liability insurance in the amount of not less than $1,000,000 per occurrence and
$2,000,000 in the annual aggregate. Sublessee shall provide Sublessor with a
certificate of insurance prior to the Commencement Date. If any such insurance
is significantly reduced or terminated prior to the term hereof, Sublessee shall
immediately notify Sublessor of the same. Such insurance shall name Sublessor as
an additional insured. Any policy carried by either party hereto affecting the
Master Premises, Subleased Premises the contents of the same or the operations
therein, shall include a clause or endorsement denying the insurer any rights of
subrogation against the other party to the extent rights have been waived by the
insured before the

                                       5
<PAGE>

occurrence of injury or loss, if the same are obtainable without unreasonable
cost.

                   TERMINATION OF MASTER LEASE/NON-DISTURBANCE

        12. In the event this Sublease terminates prior to the termination of
the term hereof for any reason other than as a result of an event of default by
Sublessee hereunder, then the Sublease shall continue in full force and effect,
at Sublessee's option, as a direct lease between Lessor and Sublessee upon all
the terms, covenants and conditions of this Sublease and Lessor shall recognize
Sublessee's right to possession of the Subleased Premises as provided for in the
Sublease and shall not disturb Sublessee's right to possession so long as an
event of default does not exist in the performance of Sublessee's obligations
under the Sublease.

                                 ATTORNEY'S FEES

        13. If any action or other proceeding arising out of this Sublease is
commenced by either party to this Sublease concerning the Subleased Premises,
then as between Sublessor and Sublessee, the prevailing party shall be entitled
to receive from the other party, in addition to any other relief that may be
granted, the reasonable attorney's fees, costs, and expenses incurred in the
action or other proceeding by the prevailing party.

                                 CONFIDENTIALITY

        14. The parties hereto acknowledge that the terms of this Sublease are
confidential and the parties hereby agree that the terms hereof as well as any
and all discussions and negotiations related to the occupation of the Subleased
Premises by Sublessee shall remain confidential and shall not be disclosed
without the prior written consent of Sublessee.

                                  COUNTERPARTS

        15. This Sublease may be signed in two or more counterparts, each of
which shall be deemed an original and all of which shall constitute one
agreement.

                                       6
<PAGE>

        IN WITNESS WHEREOF, the parties have executed this Sublease as of the
date first specified above.

                                        SUBLESSOR:

                                        Connetics Corporation,
                                        a Delaware corporation

                                        By: /s/ JOHN L. HIGGINS
                                           -------------------------------------

                                        Name: John L. Higgins
                                             -----------------------------------

                                        Its: CFO
                                            ------------------------------------

                                        SUBLESSEE:

                                        Respond.com, Inc.,
                                        a Delaware corporation

                                        By: /s/ DANA STALDER
                                           -------------------------------------

                                        Name: Dana Stalder
                                             -----------------------------------

                                        Its: CFO
                                            ------------------------------------

                                       7
<PAGE>

                                    SUBLEASE

                           (3294 West Bayshore Avenue)

        This sublease ("Sublease") is executed this 21st day of August, 2001, by
and between Connetics Corporation, a Delaware corporation (the "Sublessor"), and
Respond.com, Inc., a Delaware corporation (the "Sublessee").

                                    RECITALS

        A. West Bayshore Associates, a general partnership, Sigrid S. Banks,
Frank Lee Crist, Jr., Allen W. Koering and George O. McKee, as lessor
(collectively, "Lessor"), and Sublessor, as lessee, executed a lease dated
November 20, 1998 (the "Master Lease");

        B. By the terms of the Master Lease, approximately 13,464 rentable
square feet of the building located at 3294 West Bayshore Avenue, Palo Alto,
California, as such premises are more fully described in the Master Lease
("Master Premises") attached as Exhibit A hereto and a made a part hereof, was
leased to Sublessor for a term of thirty seven (37) months, commencing on
January 1, 1999, and ending on January 31, 2002, subject to earlier termination
as provided in the Master Lease;

        C. The term of the Master Lease has been extended in accordance with
Section 4 of the Master Lease for one (1) additional year such that the current
expiration date is January 31, 2003, as such extension has been acknowledged by
Lessor in the letter dated August 10, 2001, and attached as Exhibit B hereto and
made a part hereof;

        D. Pursuant to the terms of that certain Sublease dated as of the date
hereof by and between Sublessor, as sublessor, and Sublessee, as sublessee (the
"3290 Sublease") attached as Exhibit C hereto and made a part hereof, Sublessee
will be subleasing a portion of the premises located at 3290 West Bayshore
Avenue, Palo Alto ("3290 Premises"), which premises are adjacent to the Master
Premises, upon the terms and conditions of the 3290 Sublease.

        E. Sublessor desires to sublease to Sublessee a portion of the Master
Premises, and Sublessee desires to lease a portion of the Master Premises from
Sublessor; and,

        F. Capitalized terms used but not defined herein shall have the meaning
ascribed to them in the Master Lease.

        THEREFORE, Sublessor and Sublessee agree as follows:

                       LEASING AND DESCRIPTION OF PROPERTY

        1. Subject to the terms, conditions, and covenants set forth in this
Sublease, Sublessor hereby subleases to Sublessee, and Sublessee hereby
subleases from Sublessor, approximately 13,200 square

                                       1
<PAGE>

fee of the Master Premises as shown on Exhibit D attached hereto and made a part
hereof (the "Subleased Premises").

                                      TERM

        2. The term of this Sublease shall commence on the later of (i) October
22, 2001, (ii) the date Sublessor delivers possession of the Subleased Premises
to Sublessee, or (iii) the date of Lessor's written consent to this Sublease
("Commencement Date"), and shall end upon the expiration of the term of the
Master Lease, as extended. Notwithstanding any other provision of this Sublease
to the contrary, if the Commencement Date has not occurred by December 1, 2001
for any reason, then Sublessee may terminate this Sublease by providing written
notice thereof to Sublessor, and upon Sublessor's receipt of such notice, this
Sublease shall terminate, and Sublessor shall promptly return to Sublessee all
sums previously paid or deposited by Sublessee.

                                      RENT

        3. Sublessee shall pay to Sublessor as rent for the Subleased Premises a
rental of Twenty Seven Thousand Six Hundred Ninety Eight and 81/100 dollars
($27,698.81) per month payable in advance on the first day of each calendar
month during the term, commencing on the Commencement Date. Rent shall be paid
to Sublessor at 3290 West Bayshore, Palo Alto, CA, or at any other place
designated in writing by Sublessor. The installment rent payable for any portion
of a calendar month shall be a pro rata portion of the installment payable for a
full calendar month. The amount of rental shall be subject to annual CPI
increases as set forth in Section 6(a) of the Master Lease. Sublessee shall also
pay its prorated share of real property taxes and assessments (general and
special), insurance, maintenance, Landlord management fee and such other costs
and fees set forth in Section 6(b) of the Master Lease.

                                SECURITY DEPOSIT

        4. (a) Pursuant to the 3290 Sublease, Sublessee has previously deposited
with Sublessor the total sum of Three Hundred Four Thousand Nine Hundred Ninety
Six and 16/100 dollars ($304,996.16) as a security deposit. Upon the
Commencement Date, the security deposit held under the 3290 Sublease shall be
deemed to be the security deposit under this Sublease (the "Security Deposit").
If any portion of the security deposit held under the 3290 Sublease has been
used or applied by Sublessor in accordance with Section 4 of the 3290 Sublease,
and Sublessee has not replenished such security deposit to the full amount
required thereunder prior to the Commencement Date of this Sublease, then
Sublessee agrees to deposit with Sublessor such additional sums as may be
required such that the total Security Deposit held hereunder is $304,996.16.
During the term hereof, if Sublessee defaults with respect to any provision of
this Sublease, including, but not limited to, the provisions relating to rent,
Sublessee may (but shall not be required to) use or apply all or any part of
this security deposit for the payment of rent or any other sum

                                       2
<PAGE>

in default. If any portion of said deposit is so used or applied, Sublessee
shall, within (5) days after written demand therefore, deposit cash with
Sublessor in an amount sufficient to restore the security deposit to its
original amount. Upon the expiration or earlier termination of this Sublease,
the Security Deposit, or so much thereof as has not theretofore been applied by
Sublessor, shall be returned to Sublessee promptly, and, in any event, not to
exceed ten (10) days after such expiration or termination.

                (b) Notwithstanding the foregoing, the Security Deposit shall be
reduced by Thirty Six Thousand Six Hundred Twenty Eight and 17/100 dollars
($36,628.17) each month during the last six (6) months of the term hereof, so
long as Sublessee is not then in default hereunder, and has not been in default
beyond any applicable notice and cure period during the six (6) month period
immediately preceding such reduction. Each monthly reduction in the Security
Deposit shall be applied or paid in the following order: (i) towards the monthly
base rental next owing hereunder, and (ii) towards any other sums due from
Sublessee to Sublessor.

                    USE OF PREMISES AND ACCESS TO SERVER ROOM

        5. (a) Sublessee shall use the Subleased Premises for the purposes set
forth in the Master Lease and for no other purpose. The Subleased Premises do
not include Sublessor's IT server facilities as shown as cross-hatched on
Exhibit D ("Server Room"). During the term hereof, authorized personnel of
Sublessor (not to exceed a total of six at any given time) shall have the right
to access the Server Room through the Subleased Premises. "Authorized personnel"
as used herein shall mean those employees of Sublessor the names of whom have
been provided in writing to Sublessee, and who have been approved in writing by
Sublessee. Sublessor shall not substitute any authorized personnel without the
prior written approval of Sublessee. Any access through the Subleased Premises
as provided herein shall be during normal business hours and Sublessee shall
have the right to accompany any such authorized personnel through the Subleased
Premises to the Server Room. Sublessor hereby agrees that it shall indemnify,
defend, protect and hold harmless Sublessee from and against any and all claims
or liability for any injury or damage to any person or property, including any
reasonable attorneys' fees, occurring in, on or about the Subleased Premises or
the Server Room to the extent such injury or damages is caused by its, or its
employees', agents' or contractors' negligence or willful misconduct.

                (b) For purposes of this Section 5, the terms "Disclosing Party"
and "Receiving Party" shall mean either Sublessor or Sublessee, as applicable.
All information disclosed by the Disclosing Party to the Receiving Party during
the term of this Sublease shall be deemed to be "Proprietary Information." In
particular, Proprietary Information shall be deemed to include any trade secret,
information, prices, technique, algorithm, computer

                                       3
<PAGE>

program (source and object codes), design, drawing, formula or test data,
relating to any research project, work in process, future development,
engineering, manufacturing, marketing, servicing, financing or personnel matter
relating to the Disclosing Party, its present or future products, sales,
suppliers, clients, customers, employees, investors or business, whether in
oral, written, graphic or electronic form. The term "Proprietary Information" as
used in this Section 5 shall not be deemed to include information which the
Receiving Party can demonstrate by competent written proof: (a) is now, or
hereafter becomes, through no act or failure to act on the part of the Receiving
Party, generally known or available; (b) is known by the Receiving Party at the
time of receiving such information, as evidenced by its records; (c) is
hereafter furnished to the Receiving Party by a third party, as a matter of
right and without restriction on disclosure; or (d) is the subject of a written
permission to disclose provided by the Disclosing Party. The Receiving Party
shall maintain all Proprietary Information in trust and confidence and shall not
disclose any Proprietary Information to any third party or use any Proprietary
Information for any unauthorized purpose. The Receiving Party shall not use
Proprietary Information for any purpose or in any manner which would constitute
a violation of any laws or regulations, including without limitation the export
control laws of the United States. No rights or licenses to trademarks,
inventions, copyrights or patents are implied or granted hereunder. The
Receiving Party shall advise its employees who might have access to Proprietary
Information of the confidential nature thereof and agrees that its employees
shall be bound by the terms of this Section 5. The Receiving Party agrees to
indemnify the Disclosing Party for any loss or damage suffered as a result of
any breach by the Receiving Party of the terms of this Section 5, including any
reasonable fees incurred by the Disclosing Party in the collection of such
indemnity.

                                 QUIET ENJOYMENT

        6. Sublessor covenants that Sublessee shall be entitled to quiet
enjoyment of the Subleased Premises, provided that Sublessee complies with the
terms of this Sublease.

                              CONDITION OF PREMISES

        7 Sublessee agrees that Sublessee's act of taking possession will be an
acknowledgment that the Subleased Premises are in a tenantable condition.
Sublessee shall maintain the Subleased Premises in accordance with the terms and
conditions of the Master Lease, as incorporated below, provided, however, that
Sublessee shall have the right to surrender the Subleased Premises in the
current "as is" condition upon the expiration or earlier termination of this
Sublease, and shall have no obligation to remove any portion of the tenant
improvements, alterations or other additions made to the Subleased Premises by
any party other than Sublessee.

                          APPLICABILITY OF MASTER LEASE

                                       4
<PAGE>

        8. Except as otherwise provided in this Sublease, all of the terms and
provisions of the Master Lease are incorporated into and made a part of this
Sublease, and the rights and obligations under the Master Lease are hereby
imposed upon the parties hereto with respect to the Subleased Premises, the
Sublessor being substituted for the Lessor or Landlord in the Master Lease and
the Sublessee being substituted for the Tenant in the Master Lease and the
Subleased Premises being substituted for the Premises in the Master Lease;
provided, however, that the term "Landlord" in the following sections of the
Master Lease shall mean (i) Lessor, not Sublessor: 11, 12, 13, 17(b), 21, 22,
25, and 32; and (ii) both Lessor and Sublessor: 15, 16, and 31. Notwithstanding
the foregoing, the following sections of the Master Lease are not incorporated
herein: 8 and 33. In the event of any conflict between the terms of this
Sublease and the Master Lease, the terms and conditions of this Sublease shall
control.

               SUBLESSEE'S RIGHTS REGARDING CONTINUING POSSESSION

        9. Sublessee shall have the right at any time, at Sublessor's expense,
to take any action required to be taken, but not timely taken, by Sublessor,
that may be necessary to prevent a default under the terms of the Master Lease.
If Sublessor is provided with the right, under the terms of the Master Lease, to
terminate the Master Lease before the expiration of its term, Sublessee rather
than Sublessor shall have the right to make that decision. Nothing contained in
this sublease shall be construed so as to deprive Sublessee of Sublessee's right
to surrender or otherwise terminate this Sublease as provided by law.

                            OBLIGATIONS OF SUBLESSOR

        10. Sublessor agrees to maintain the Master Lease during the entire term
of this Sublease, subject, however, to any earlier termination of the Master
Lease without the fault of Sublessor. Sublessor also agrees to pay all rentals
and taxes as provided for in the Master Lease in accordance with its terms, and
to comply with or perform all obligations under the Master Lease that Sublessee
has not assumed under this Sublease. Further, Sublessor agrees not to modify or
surrender the Master Lease without the prior written consent of Sublessee, which
Sublessee may withhold in its sole discretion. Any modification or surrender
made without that consent shall be null and void and shall have no effect on the
rights of Sublessee under this Sublease. Except as otherwise set forth herein,
Sublessor does not assume the obligations required to be kept or performed by
the Lessor under the Master Lease.

                           EARLY OCCUPANCY, INSURANCE

        11. (a) Sublessee shall have the right to occupy the Subleased Premises
for a period of five (5) business days prior to the Commencement Date, without
any obligation to pay any rental or other sums specified hereunder, for the
purpose of installing its data

                                       5
<PAGE>

lines, telecommunications lines, and other cabling. Sublessee shall use
commercially reasonable efforts to minimize any disruption of Sublessor's
business operations during such installation.

                (b) Sublessee shall maintain during the term hereof commercial
general liability insurance in the amount of not less than $1,000,000 per
occurrence and $2,000,000 in the annual aggregate. Sublessee shall provide
Sublessor with a certificate of insurance prior to the Commencement Date. If any
such insurance is significantly reduced or terminated prior to the term hereof,
Sublessee shall immediately notify Sublessor of the same. Such insurance shall
name Sublessor as an additional insured. Any policy carried by either party
hereto affecting the Master Premises, Subleased Premises the contents of the
same or the operations therein, shall include a clause or endorsement denying
the insurer any rights of subrogation against the other party to the extent
rights have been waived by the insured before the occurrence of injury or loss,
if the same are obtainable without unreasonable cost.

                   TERMINATION OF MASTER LEASE/NON-DISTURBANCE

        12. In the event this Sublease terminates prior to the termination of
the term hereof for any reason other than as a result of an event of default by
Sublessee hereunder, then the Sublease shall continue in full force and effect,
at Sublessee's option, as a direct lease between Lessor and Sublessee upon all
the terms, covenants and conditions of this Sublease and Lessor shall recognize
Sublessee's right to possession of the Subleased Premises as provided for in the
Sublease and shall not disturb Sublessee's right to possession so long as an
event of default does not exist in the performance of Sublessee's obligations
under the Sublease.

                                 ATTORNEY'S FEES

        13. If any action or other proceeding arising out of this Sublease is
commenced by either party to this Sublease concerning the Subleased Premises,
then as between Sublessor and Sublessee, the prevailing party shall be entitled
to receive from the other party, in addition to any other relief that may be
granted, the reasonable attorney's fees, costs, and expenses incurred in the
action or other proceeding by the prevailing party.

                                 CONFIDENTIALITY

        14. The parties hereto acknowledge that the terms of this Sublease are
confidential and the parties hereby agree that the terms hereof as well as any
and all discussions and negotiations related to the occupation of the Subleased
Premises by Sublessee shall remain confidential and shall not be disclosed
without the prior written

                                       6
<PAGE>

consent of Sublessee.

                                  COUNTERPARTS

        15. This Sublease may be signed in two or more counterparts, each of
which shall be deemed an original and all of which shall constitute one
agreement.

                                       7
<PAGE>

        IN WITNESS WHEREOF, the parties have executed this Sublease as of the
date first specified above.

                                        SUBLESSOR:

                                        Connetics Corporation,
                                        a Delaware corporation

                                        By: /s/ JOHN L. HIGGINS
                                           -------------------------------------

                                        Name: John L. Higgins
                                             -----------------------------------

                                        Its: CFO
                                            ------------------------------------

                                        SUBLESSEE:

                                        Respond.com, Inc.,
                                        a Delaware corporation

                                        By: /s/ DANA STALDER
                                           -------------------------------------

                                        Name: Dana Stalder
                                             -----------------------------------

                                        Its: CFO
                                            ------------------------------------

                                       8

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