Document:

EX-10.22

 Exhibit 10.22 

DERMTECH, INC. 
 RIGHT
OF FIRST REFUSAL AND CO-SALE AGREEMENT 
 September 26, 2017 

 TABLE OF CONTENTS 

 

									
	 	 	 	  	 	  	Page	 
	 1.
	 	Definitions	  	 	1	
			
	 2.
	 	Agreement Among the Company, the Investors and the Key Holders	  	 	3	
		 	2.1	  	Right of First Refusal	  	 	3	
		 	2.2	  	Right of Co-Sale	  	 	5	
		 	2.3	  	Effect of Failure to Comply	  	 	7	
			
	 3.
	 	Exempt Transfers	  	 	7	
		 	3.1	  	Exempted Transfers	  	 	7	
		 	3.2	  	Exempted Offerings	  	 	8	
		 	3.3	  	Prohibited Transferees	  	 	8	
		 	3.4	  	No Transfers to Bad Actors	  	 	8	
			
	 4.
	 	Legend	  	 	9	
			
	 5.
	 	Lock-Up	  	 	9	
		 	5.1	  	Agreement to Lock-Up	  	 	9	
		 	5.2	  	Stop Transfer Instructions	  	 	10	
			
	 6.
	 	Miscellaneous	  	 	10	
		 	6.1	  	Term	  	 	10	
		 	6.2	  	Stock Split	  	 	10	
		 	6.3	  	Ownership	  	 	10	
		 	6.4	  	Governing Law; Venue	  	 	10	
		 	6.5	  	Notices	  	 	10	
		 	6.6	  	Entire Agreement	  	 	11	
		 	6.7	  	Delays or Omissions	  	 	11	
		 	6.8	  	Amendment; Waiver and Termination	  	 	11	
		 	6.9	  	Assignment of Rights	  	 	12	
		 	6.10	  	Severability	  	 	12	
		 	6.11	  	Additional Investors	  	 	12	
		 	6.12	  	Titles and Subtitles	  	 	12	
		 	6.13	  	Counterparts	  	 	12	
		 	6.14	  	Aggregation of Stock	  	 	13	
		 	6.15	  	Specific Performance	  	 	13	

					
			
	 Schedule A
	 	-	  	Investors
	 Schedule B
	 	-	  	Key Holders
	 Exhibit A
	 	-	  	Consent of Spouse

  
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 RIGHT OF FIRST REFUSAL 

AND CO-SALE AGREEMENT 

THIS RIGHT OF FIRST REFUSAL AND CO-SALE AGREEMENT (this “Agreement”), is made as of
the 26th day of September, 2017 by and among DermTech, Inc., a Delaware corporation (the “Company”), the Investors listed on Schedule A and the Key
Holders listed on Schedule B. 
 WHEREAS, each Key Holder is the beneficial owner of the number of shares
of Capital Stock, or of options to purchase Common Stock, set forth opposite the name of such Key Holder on Schedule B; 

WHEREAS, the Company and the Investors are parties to the Amended and Restated Series C Preferred Securities Purchase Agreement, of
even date herewith (the “Purchase Agreement”), pursuant to which the Investors have agreed to purchase shares of the Series C Preferred Stock of the Company, par value $0.001 per share (“Series C Preferred Stock”);
and 
 WHEREAS, the Key Holders and the Company desire to further induce the Investors to purchase the Series C Preferred Stock; 

1.    Definitions. 

1.1 “Affiliate” means, with respect to any specified Investor, any other Investor who directly or indirectly, controls, is
controlled by or is under common control with such Investor, including, without limitation, any general partner, managing member, officer or director of such Investor, or any venture capital fund now or hereafter existing which is controlled by one
or more general partners or managing members of, or shares the same management company with, such Investor. 
 1.2 “Capital
Stock” means (a) shares of Common Stock and Preferred Stock (whether now outstanding or hereafter issued in any context), (b) shares of Common Stock issued or issuable upon conversion of Preferred Stock, and (c) shares of Common
Stock issued or issuable upon exercise or conversion, as applicable, of stock options, warrants or other convertible securities of the Company, in each case now owned or subsequently acquired by any Key Holder, any Investor, or their respective
successors or permitted transferees or assigns. For purposes of the number of shares of Capital Stock held by an Investor or Key Holder (or any other calculation based thereon), all shares of Preferred Stock shall be deemed to have been converted
into Common Stock at the then-applicable conversion ratio. 
 1.3 “Common Stock”
means shares of Common Stock of the Company, $0.001 par value per share. 
 1.4 “Company Notice” means written notice from
the Company notifying the selling Key Holders that the Company intends to exercise its Right of First Refusal as to some or all of the Transfer Stock with respect to any Proposed Key Holder Transfer. 

  
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 1.5 “Investor Notice” means written notice from an Investor notifying the
Company and the selling Key Holder that such Investor intends to exercise its Secondary Refusal Right as to a portion of the Transfer Stock with respect to any Proposed Key Holder Transfer. 

1.6 “Investors” means the persons named on Schedule A hereto, each person to whom the rights of an
Investor are assigned pursuant to Subsection 6.9, each person who hereafter becomes a signatory to this Agreement pursuant to Subsection 6.11 and any one of them, as the context may require; provided, however, that any
such person shall cease to be considered an Investor for purposes of this Agreement at any time such person and his, her or its Affiliates collectively hold fewer than 50,000 shares of Series C Preferred Stock (as adjusted for any stock combination,
stock split, stock dividend, recapitalization or other similar transaction). 
 1.7 “Key Holders” means the persons named
on Schedule B hereto, each person to whom the rights of a Key Holder are assigned pursuant to Subsection 3.1, each person who hereafter becomes a signatory to this Agreement pursuant to Subsection 6.9 or
Error! Reference source not found. and any one of them, as the context may require. 
 1.8 “Liquidation
Transaction” has the meaning set forth in the Restated Charter. 
 1.9 “Preferred Stock” means collectively, all
shares of Series A Preferred Stock, Series B Preferred Stock, and Series C Preferred Stock. 
 1.10 “Proposed Key Holder
Transfer” means any assignment, sale, offer to sell, pledge, mortgage, hypothecation, encumbrance, disposition of or any other like transfer or encumbering of any Transfer Stock (or any interest therein) proposed by any of the Key Holders.

 1.11 “Proposed Transfer Notice” means written notice from a Key Holder setting forth the terms and conditions of a
Proposed Key Holder Transfer. 
 1.12 “Prospective Transferee” means any person to whom a Key Holder proposes to make a
Proposed Key Holder Transfer. 
 1.13 “Restated Certificate” means the Company’s Amended and Restated Certificate of
Incorporation, as amended from time to time. 
 1.14 “Right of Co-Sale” means the
right, but not an obligation, of an Investor to participate in a Proposed Key Holder Transfer on the terms and conditions specified in the Proposed Transfer Notice. 

1.15 “Right of First Refusal” means the right, but not an obligation, of the Company, or its permitted transferees or
assigns, to purchase some or all of the Transfer Stock with respect to a Proposed Key Holder Transfer, on the terms and conditions specified in the Proposed Transfer Notice. 

1.16 “Secondary Notice” means written notice from the Company notifying the Investors and the selling Key Holder that the
Company does not intend to exercise its Right 

  
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of First Refusal as to all shares of Transfer Stock with respect to any Proposed Key Holder Transfer. 

1.17 “Secondary Refusal Right” means the right, but not an obligation, of each Investor to purchase up to its pro rata
portion (based upon the total number of shares of Capital Stock then held by all Investors) of any Transfer Stock not purchased pursuant to the Right of First Refusal, on the terms and conditions specified in the Proposed Transfer Notice. 

1.18 “Transfer Stock” means shares of Capital Stock owned by a Key Holder, or issued to a Key Holder after the date hereof
(including, without limitation, in connection with any stock split, stock dividend, recapitalization, reorganization, or the like), but does not include any shares of Preferred Stock or of Common Stock that are issued or issuable upon conversion of
Preferred Stock. 
 1.19 “Undersubscription Notice” means written notice from an Investor notifying the Company and the
selling Key Holder that such Investor intends to exercise its option to purchase all or any portion of the Transfer Stock not purchased pursuant to the Right of First Refusal or the Secondary Refusal Right. 

2.    Agreement Among the Company, the Investors and the Key Holders. 

2.1    Right of First Refusal. 

(a)    Grant. Subject to the terms of Section 3 below, each Key Holder hereby
unconditionally and irrevocably grants to the Company a Right of First Refusal to purchase all or any portion of Transfer Stock that such Key Holder may propose to transfer in a Proposed Key Holder Transfer, at the same price and on the same terms
and conditions as those offered to the Prospective Transferee. 
 (b)    Notice. Each Key Holder proposing to
make a Proposed Key Holder Transfer must deliver a Proposed Transfer Notice to the Company and each Investor not later than forty-five (45) days prior to the consummation of such Proposed Key Holder Transfer. Such Proposed Transfer Notice shall
contain the material terms and conditions (including price and form of consideration) of the Proposed Key Holder Transfer, the identity of the Prospective Transferee and the intended date of the Proposed Key Holder Transfer. To exercise its Right of
First Refusal under this Section 2, the Company must deliver a Company Notice to the selling Key Holder within fifteen (15) days after delivery of the Proposed Transfer Notice. In the event of a conflict between this
Agreement and the Company’s Bylaws containing a preexisting right of first refusal, the terms of the Bylaws will control and compliance with the Bylaws shall be deemed compliance with this Subsection 2.1(a) and (b) in full.

 (c)    Grant of Secondary Refusal Right to Investors. Subject to the terms of
Section 3 below, each Key Holder hereby unconditionally and irrevocably grants to the Investors a Secondary Refusal Right to purchase all or any portion of the Transfer Stock not purchased by the Company pursuant to the
Right of First Refusal, as provided in this Subsection 2.1(c). If the Company does not intend to exercise its Right of First Refusal with respect to all Transfer Stock subject to a Proposed Key Holder Transfer, the Company must deliver a
Secondary Notice to the selling Key Holder and to each Investor to that effect no later than 

  
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fifteen (15) days after the selling Key Holder delivers the Proposed Transfer Notice to the Company. To exercise its Secondary Refusal Right, an Investor must deliver an Investor Notice to
the selling Key Holder and the Company within ten (10) days after the Company’s deadline for its delivery of the Secondary Notice as provided in the preceding sentence or such Investor shall be deemed to have declined to exercise its
Secondary Right of First Refusal. 
 (d)    Undersubscription of Transfer Stock. If options to purchase have
been exercised by the Company and the Investors with respect to some but not all of the Transfer Stock by the end of the ten (10) day period specified in the last sentence of Subsection 2.1(c) (the “Investor Notice
Period”), then the Company shall, immediately after the expiration of the Investor Notice Period, send written notice (the “Company Undersubscription Notice”) to those Investors who fully exercised their Secondary Refusal
Right within the Investor Notice Period (the “Exercising Investors”). Each Exercising Investor shall, subject to the provisions of this Subsection 2.1(d), have an additional option to purchase all or any part of the balance
of any such remaining unsubscribed shares of Transfer Stock on the terms and conditions set forth in the Proposed Transfer Notice. To exercise such option, an Exercising Investor must deliver an Undersubscription Notice to the selling Key Holder and
the Company within ten (10) days after the expiration of the Investor Notice Period. In the event there are two (2) or more such Exercising Investors that choose to exercise the last-mentioned option for a total number of remaining shares
in excess of the number available, the remaining shares available for purchase under this Subsection 2.1(d) shall be allocated to such Exercising Investors pro rata based on the number of shares of Transfer Stock such Exercising Investors
have elected to purchase pursuant to the Secondary Refusal Right (without giving effect to any shares of Transfer Stock that any such Exercising Investor has elected to purchase pursuant to the Company Undersubscription Notice). If the options to
purchase the remaining shares are exercised in full by the Exercising Investors, the Company shall immediately notify all of the Exercising Investors and the selling Key Holder of that fact. 

(e)    Forfeiture of Rights. Notwithstanding the foregoing, if the total number of shares of Transfer Stock that
the Company and the Investors have agreed to purchase in the Company Notice, Investor Notices and Undersubscription Notices is less than the total number of shares of Transfer Stock, then the Company and the Investors shall be deemed to have
forfeited any right to purchase such Transfer Stock, and the selling Key Holder shall be free to sell all, but not less than all, of the Transfer Stock to the Prospective Transferee on terms and conditions substantially similar to (and in no event
more favorable than) the terms and conditions set forth in the Proposed Transfer Notice, it being understood and agreed that (i) any such sale or transfer shall be subject to the other terms and restrictions of this Agreement, including,
without limitation, the terms and restrictions set forth in Subsections 2.2 and 6.9(b); (ii) any future Proposed Key Holder Transfer shall remain subject to the terms and conditions of this Agreement, including this
Section 2; and (iii) such sale shall be consummated within forty-five (45) days after receipt of the Proposed Transfer Notice by the Company and, if such sale is not consummated within such forty-five
(45) day period, such sale shall again become subject to the Right of First Refusal and Secondary Refusal Right on the terms set forth herein. 

(f)    Consideration; Closing. If the consideration proposed to be paid for the Transfer Stock is in property,
services or other non-cash consideration, the fair market value of the consideration shall be as determined in good faith by the Company’s Board of 

  
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Directors and as set forth in the Company Notice. If the Company or any Investor cannot for any reason pay for the Transfer Stock in the same form of
non-cash consideration, the Company or such Investor may pay the cash value equivalent thereof, as determined in good faith by the Board of Directors and as set forth in the Company Notice. The closing of the
purchase of Transfer Stock by the Company and the Investors shall take place, and all payments from the Company and the Investors shall have been delivered to the selling Key Holder, by the later of (i) the date specified in the Proposed
Transfer Notice as the intended date of the Proposed Key Holder Transfer; and (ii) forty-five (45) days after delivery of the Proposed Transfer Notice. 

(g)    No Right of First Refusal for Bad Actors. No Investor shall have a Secondary Refusal Right if the Investor
or any of its directors, executive officers, other officers that may serve as a director or officer of any company in which it invests, general partners or managing members or any person that is a beneficial owner of the securities of the Company
held by the Investor (in accordance with Rule 506(d) of the Securities Act) is subject to any Bad Actor Disqualification, except for Bad Actor Disqualifications covered by Rule 506(d)(2)(ii) or (iii) or (d)(3) under the Securities Act and
disclosed in writing in reasonable detail to the Company. 
 2.2    Right of
Co-Sale. 
 (a)    Exercise of Right. If any Transfer Stock subject
to a Proposed Key Holder Transfer is not purchased pursuant to Subsection 2.1 above and thereafter is to be sold to a Prospective Transferee, each respective Investor may elect to exercise its Right of
Co-Sale and participate on a pro rata basis in the Proposed Key Holder Transfer as set forth in Subsection 2.2(b) below and, subject to Subsection 2.2(d), otherwise on the same terms and
conditions specified in the Proposed Transfer Notice. Each Investor who desires to exercise its Right of Co-Sale (each, a “Participating Investor”) must give the selling Key Holder written
notice to that effect within fifteen (15) days after the deadline for delivery of the Secondary Notice described above, and upon giving such notice such Participating Investor shall be deemed to have effectively exercised the Right of Co-Sale. 
 (b)    Shares Includable. Each Participating Investor may include
in the Proposed Key Holder Transfer all or any part of such Participating Investor’s Capital Stock equal to the product obtained by multiplying (i) the aggregate number of shares of Transfer Stock subject to the Proposed Key Holder
Transfer (excluding shares purchased by the Company or the Participating Investors pursuant to the Right of First Refusal or the Secondary Refusal Right) by (ii) a fraction, the numerator of which is the number of shares of Capital Stock owned
by such Participating Investor immediately before consummation of the Proposed Key Holder Transfer (including any shares that such Investor has agreed to purchase pursuant to the Secondary Refusal Right) and the denominator of which is the total
number of shares of Capital Stock owned, in the aggregate, by all Participating Investors immediately prior to the consummation of the Proposed Key Holder Transfer (including any shares that all Participating Investors have collectively agreed to
purchase pursuant to the Secondary Refusal Right), plus the number of shares of Transfer Stock held by the selling Key Holder. To the extent one (1) or more of the Participating Investors exercise such right of participation in accordance with
the terms and conditions set forth herein, the number of shares of Transfer Stock that the selling Key Holder may sell in the Proposed Key Holder Transfer shall be correspondingly reduced. 

  
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 (c)    Purchase and Sale Agreement. The Participating Investors
and the selling Key Holder agree that the terms and conditions of any Proposed Key Holder Transfer in accordance with Subsection 2.2 will be memorialized in, and governed by, a written purchase and sale agreement with the Prospective
Transferee (the “Purchase and Sale Agreement”) with customary terms and provisions for such a transaction, and the Participating Investors and the selling Key Holder further covenant and agree to enter into such Purchase and Sale
Agreement as a condition precedent to any sale or other transfer in accordance with this Subsection 2.2. 

(d)    Allocation of Consideration. 

(i)    Subject to Subsection 2.2(d)(ii), the aggregate consideration payable to the Participating Investors and the
selling Key Holder shall be allocated based on the number of shares of Capital Stock sold to the Prospective Transferee by each Participating Investor and the selling Key Holder as provided in Subsection 2.2(b), provided that if a
Participating Investor wishes to sell Preferred Stock, the price set forth in the Proposed Transfer Notice shall be appropriately adjusted based on the conversion ratio of such series of Preferred Stock into Common Stock. 

(e)    Purchase by Selling Key Holder; Deliveries. Notwithstanding Subsection 2.2(c) above, if any
Prospective Transferee or Transferees refuse(s) to purchase securities subject to the Right of Co-Sale from any Participating Investor or Investors or upon the failure to negotiate in good faith a Purchase and
Sale Agreement reasonably satisfactory to the Participating Investors, no Key Holder may sell any Transfer Stock to such Prospective Transferee or Transferees unless and until, simultaneously with such sale, such Key Holder purchases all securities
subject to the Right of Co-Sale from such Participating Investor or Investors on the same terms and conditions (including the proposed purchase price) as set forth in the Proposed Transfer Notice and as
provided in Subsection 2.2(d)(i). In connection with such purchase by the selling Key Holder, such Participating Investor or Investors shall deliver to the selling Key Holder any stock certificate or certificates, properly endorsed for
transfer, representing the Capital Stock being purchased by the selling Key Holder (or request that the Company effect such transfer in the name of the selling Key Holder). Any such shares transferred to the selling Key Holder will be transferred to
the Prospective Transferee against payment therefor in consummation of the sale of the Transfer Stock pursuant to the terms and conditions specified in the Proposed Transfer Notice, and the selling Key Holder shall concurrently therewith remit or
direct payment to each such Participating Investor the portion of the aggregate consideration to which each such Participating Investor is entitled by reason of its participation in such sale as provided in this Subsection 2.2(e). 

(f)    Additional Compliance. If any Proposed Key Holder Transfer is not consummated within forty-five
(45) days after receipt of the Proposed Transfer Notice by the Company, the Key Holders proposing the Proposed Key Holder Transfer may not sell any Transfer Stock unless they first comply in full with each provision of this
Section 2. The exercise or election not to exercise any right by any Investor hereunder shall not adversely affect its right to participate in any other sales of Transfer Stock subject to this
Subsection 2.2. 

  
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 2.3    Effect of Failure to Comply. 

(a)    Transfer Void; Equitable Relief. Any Proposed Key Holder Transfer not made in compliance with the
requirements of this Agreement shall be null and void ab initio, shall not be recorded on the books of the Company or its transfer agent and shall not be recognized by the Company. Each party hereto acknowledges and agrees that any breach of this
Agreement would result in substantial harm to the other parties hereto for which monetary damages alone could not adequately compensate. Therefore, the parties hereto unconditionally and irrevocably agree that any
non-breaching party hereto shall be entitled to seek protective orders, injunctive relief and other remedies available at law or in equity (including, without limitation, seeking specific performance or the
rescission of purchases, sales and other transfers of Transfer Stock not made in strict compliance with this Agreement). 

(b)    Violation of First Refusal Right. If any Key Holder becomes obligated to sell any Transfer Stock to the
Company or any Investor under this Agreement and fails to deliver such Transfer Stock in accordance with the terms of this Agreement, the Company and/or such Investor may, at its option, in addition to all other remedies it may have, send to such
Key Holder the purchase price for such Transfer Stock as is herein specified and transfer to the name of the Company or such Investor (or request that the Company effect such transfer in the name of an Investor) on the Company’s books any
certificates, instruments, or book entry representing the Transfer Stock to be sold. 
 (c)    Violation of Co-Sale Right. If any Key Holder purports to sell any Transfer Stock in contravention of the Right of Co-Sale (a “Prohibited Transfer”), each Investor who
desires to exercise its Right of Co-Sale under Subsection 2.2 may, in addition to such remedies as may be available by law, in equity or hereunder, require such Key Holder to purchase from such Investor
the type and number of shares of Capital Stock that such Investor would have been entitled to sell to the Prospective Transferee had the Prohibited Transfer been effected in compliance with the terms of Subsection 2.2. The sale will be made
on the same terms, including, without limitation, as provided in Subsection 2.2(d)(i) and the first sentence of Subsection 2.2(d)(ii), as applicable, and subject to the same conditions as would have applied had the Key Holder not made
the Prohibited Transfer, except that the sale (including, without limitation, the delivery of the purchase price) must be made within ninety (90) days after the Investor learns of the Prohibited Transfer, as opposed to the timeframe proscribed
in Subsection 2.2. Such Key Holder shall also reimburse each Investor for any and all reasonable and documented out-of-pocket fees and
expenses, including reasonable legal fees and expenses, incurred pursuant to the exercise or the attempted exercise of the Investor’s rights under Subsection 2.2. 

3.    Exempt Transfers. 

3.1    Exempted Transfers. Notwithstanding the foregoing or anything to the contrary herein, the provisions of
Subsections 2.1 and 2.2 shall not apply (a) in the case of a Key Holder that is an entity, upon a transfer by such Key Holder to its stockholders, members, partners or other equity holders, (b) to a repurchase of Transfer
Stock from a Key Holder by the Company at a price no greater than that originally paid by such Key Holder for such Transfer Stock and pursuant to an agreement containing vesting and/or repurchase provisions approved by

  
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a majority of the Board of Directors, (c) to a pledge of Transfer Stock that creates a mere security interest in the pledged Transfer Stock, provided that the pledgee thereof agrees
in writing in advance to be bound by and comply with all applicable provisions of this Agreement to the same extent as if it were the Key Holder making such pledge, or (d) in the case of a Key Holder that is a natural person, upon a transfer of
Transfer Stock by such Key Holder made for bona fide estate planning purposes, either during his or her lifetime or on death by will or intestacy to his or her spouse, child (natural or adopted), or any other direct lineal descendant of such Key
Holder (or his or her spouse) (all of the foregoing collectively referred to as “family members”), or any other person approved by unanimous consent of the Board of Directors of the Company, or any custodian or trustee of any trust,
partnership or limited liability company for the benefit of, or the ownership interests of which are owned wholly by such Key Holder or any such family members; or (e) to the sale by the Key Holder of up to 5% of the Transfer Stock held by such
Key Holder as of the date that such Key Holder first became party to this Agreement; provided that in the case of clause(s) (a), (c), (d) or (e), the Key Holder shall deliver prior written notice to the Company and the Investors of such
pledge, gift or transfer and such shares of Transfer Stock shall at all times remain subject to the terms and restrictions set forth in this Agreement and such transferee shall, as a condition to such issuance, deliver a counterpart signature page
to this Agreement as confirmation that such transferee shall be bound by all the terms and conditions of this Agreement as a Key Holder (but only with respect to the securities so transferred to the transferee), including the obligations of a Key
Holder with respect to Proposed Key Holder Transfers of such Transfer Stock pursuant to Section 2; and provided further in the case of any transfer pursuant to clause (a) or (d) above, that such transfer
is made pursuant to a transaction in which there is no consideration actually paid for such transfer. 

3.2    Exempted Offerings. Notwithstanding the foregoing or anything to the contrary herein, the provisions of
Section 2 shall not apply to the sale of any Transfer Stock (a) to the public in an offering pursuant to an effective registration statement under the Securities Act of 1933, as amended (a “Public
Offering”); or (b) pursuant to a Liquidation Transaction (as defined in the Company’s Certificate of Incorporation). 

3.3    Prohibited Transferees. Notwithstanding the foregoing, no Key Holder shall transfer any Transfer Stock to
(a) any entity which, in the determination of the Company’s Board of Directors, directly or indirectly competes with the Company; or (b) any customer, distributor or supplier of the Company, if the Company’s Board of Directors
should determine that such transfer would result in such customer, distributor or supplier receiving information that would place the Company at a competitive disadvantage with respect to such customer, distributor or supplier. 

3.4    No Transfers to Bad Actors. Each Investor and Key Holder agrees not to make any sale, assignment,
encumbrance, hypothecation, pledge, conveyance in trust, gift, transfer by bequest, devise or descent, or other transfer or disposition of any kind of any securities of the Company, or any beneficial interest therein, to any person (other than the
Company) unless and until the proposed transferee confirms to the reasonable satisfaction of the Company that neither the proposed transferee nor any of its directors, executive officers, other officers that may serve as a director or officer of any
company in which it invests, general partners or managing members nor any person that would be deemed a beneficial owner of those securities (in accordance with Rule 506(d) of the Securities Act) is subject to any Bad Actor

  
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Disqualification, except for Bad Actor Disqualifications covered by Rule 506(d)(2)(ii) or (iii) or (d)(3) under the Securities Act and disclosed, reasonably in advance of the transfer or
disposition, in writing in reasonable detail to the Company. 
 4.    Legend. Each certificate, instrument, or
book entry representing shares of Transfer Stock held by the Key Holders or issued to any permitted transferee in connection with a transfer permitted by Subsection 3.1 hereof shall be notated with the following legend:

 THE SALE, PLEDGE, HYPOTHECATION, OR TRANSFER OF THE SECURITIES REPRESENTED HEREBY IS SUBJECT TO, AND IN CERTAIN CASES PROHIBITED BY, THE
TERMS AND CONDITIONS OF A CERTAIN RIGHT OF FIRST REFUSAL AND CO-SALE AGREEMENT BY AND AMONG THE STOCKHOLDER, THE CORPORATION AND CERTAIN OTHER HOLDERS OF STOCK OF THE CORPORATION. COPIES OF SUCH AGREEMENT MAY
BE OBTAINED UPON WRITTEN REQUEST TO THE SECRETARY OF THE CORPORATION. 
 Each Key Holder agrees that the Company may instruct its transfer agent to impose
transfer restrictions on the shares notated with the legend referred to in this Section 4 above to enforce the provisions of this Agreement, and the Company agrees to promptly do so. The legend shall be removed upon
termination of this Agreement at the request of the holder. 

5.    Lock-Up. 

5.1    Agreement to Lock-Up. Each Key Holder hereby agrees that it will not,
without the prior written consent of the managing underwriter, during the period commencing on the date of the final prospectus relating to the Company’s initial public offering (the “IPO”) and ending on the date specified by
the Company and the managing underwriter (such period not to exceed one hundred eighty (l80) days), or such other period as may be requested by the Company or an underwriter to accommodate regulatory restrictions on (1) the publication or other
distribution of research reports; and (2) analyst recommendations and opinions, including, but not limited to, the restrictions contained in NYSE Rule 472(f)(4), or any successor provisions or amendments thereto), (a) lend, offer,
pledge, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or warrant to purchase, or otherwise transfer or dispose of, directly or indirectly, any shares of Capital
Stock held immediately prior to the effectiveness of the registration statement for the IPO; or (b) enter into any swap or other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of the
Capital Stock, whether any such transaction described in clause (a) or (b) above is to be settled by delivery of Capital Stock or other securities, in cash or otherwise. The foregoing provisions of this Section 5
shall not apply to the sale of any shares to an underwriter pursuant to an underwriting agreement, and shall only be applicable to the Key Holders if all officers, directors and holders of more than one percent (1%) of the outstanding Common Stock
(after giving effect to the conversion into Common Stock of all outstanding Series C Preferred Stock) enter into similar agreements. The underwriters in connection with the IPO are intended third-party
beneficiaries of this Section 5 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. Each Key Holder further agrees to execute such agreements as may be
reasonably requested by the underwriters in the IPO that are consistent with this Section 5 or that are necessary to give further effect thereto. 

  
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 5.2    Stop Transfer Instructions. In order to enforce the
foregoing covenant, the Company may impose stop-transfer instructions with respect to the shares of Capital Stock of each Key Holder (and transferees and assignees thereof) until the end of such restricted period. 

6.    Miscellaneous. 

6.1    Term. This Agreement shall automatically terminate upon the earlier of (a) immediately prior to the
consummation of the Company’s IPO; and (b) the consummation of a Liquidation Transaction (as defined in the Restated Certificate). 

6.2    Stock Split. All references to numbers of shares in this Agreement shall be appropriately adjusted to
reflect any stock dividend, split, combination or other recapitalization affecting the Capital Stock occurring after the date of this Agreement. 

6.3    Ownership. Each Key Holder represents and warrants that such Key Holder is the sole legal and beneficial
owner of the shares of Transfer Stock subject to this Agreement and that no other person or entity has any interest in such shares (other than a community property interest as to which the holder thereof has acknowledged and agreed in writing to the
restrictions and obligations hereunder). 
 6.4    Governing Law; Venue. This Agreement and all acts and
transactions pursuant hereto and the rights and obligations of the parties hereto shall be governed, construed and interpreted in accordance with the laws of the State of Delaware, without giving effect to principles of conflicts of law. The parties
(a) hereby irrevocably and unconditionally submit to the jurisdiction of the state courts of Delaware and to the jurisdiction of the United States District Court for the District of Delaware for the purpose of any suit, action or other
proceeding arising out of or based upon this Agreement, (b) agree not to commence any suit, action or other proceeding arising out of or based upon this Agreement except in the state courts of Delaware or the United States District Court for
the District of Delaware, and (c) hereby waive, and agree not to assert, by way of motion, as a defense, or otherwise, in any such suit, action or proceeding, any claim that it is not subject personally to the jurisdiction of the above-named
courts, that its property is exempt or immune from attachment or execution, that the suit, action or proceeding is brought in an inconvenient forum, that the venue of the suit, action or proceeding is improper or that this Agreement or the subject
matter hereof may not be enforced in or by such court. 
 6.5    Notices. All notices and other communications
given or made pursuant to this Agreement shall be in writing and shall be deemed effectively given upon the earlier of actual receipt or (a) personal delivery to the party to be notified, (b) when sent, if sent by electronic mail or
facsimile during normal business hours of the recipient, and if not sent during normal business hours, then on the recipient’s next business day, (c) five (5) days after having been sent by registered or certified mail, return receipt
requested, postage prepaid, or (d) one (1) business day after deposit with a nationally recognized overnight courier, freight prepaid, specifying next business day delivery, with written verification of receipt. All communications shall be sent
to the respective parties at their address as set forth on Schedule A or Schedule B hereof, as the case may be, or to such email address, facsimile number or address as subsequently modified by written notice given in accordance with
this Section 6.5. If notice is given to the Company, it shall be sent to 11099 No. Torrey Pines Rd., Suite 100, La Jolla, CA 

  
 10 

 
92037, Attention: Chief Executive Officer; and a copy (which shall not constitute notice) shall also be sent to Wilson Sonsini Goodrich & Rosati, 12235 El Camino Real, Suite 200,
San Diego, CA 92130, Attention: Martin Waters; and if notice is given to the Investors, a copy shall also be given to John Crandon, Esq., 36 Grattan Street, San Francisco, CA 94117. 

6.6    Entire Agreement. This Agreement (including, the Exhibits and Schedules hereto) constitutes the full and
entire understanding and agreement between the parties with respect to the subject matter hereof, and any other written or oral agreement relating to the subject matter hereof existing between the parties are expressly canceled. 

6.7    Delays or Omissions. No delay or omission to exercise any right, power or remedy accruing to any party under
this Agreement, upon any breach or default of any other party under this Agreement, shall impair any such right, power or remedy of such non-breaching or non-defaulting
party nor shall it be construed to be a waiver of any such breach or default, or an acquiescence therein, or of or in any similar breach or default thereafter occurring; nor shall any waiver of any single breach or default be deemed a waiver of any
other breach or default theretofore or thereafter occurring. Any waiver, permit, consent or approval of any kind or character on the part of any party of any breach or default under this Agreement, or any waiver on the part of any party of any
provisions or conditions of this Agreement, must be in writing and shall be effective only to the extent specifically set forth in such writing. All remedies, either under this Agreement or by law or otherwise afforded to any party, shall be
cumulative and not alternative. 
 6.8    Amendment; Waiver and Termination. This Agreement may be amended,
modified or terminated (other than pursuant to Section 6.1 above) and the observance of any term hereof may be waived (either generally or in a particular instance and either retroactively or prospectively) only by a
written instrument executed by (a) the Company, (b) the Key Holders holding at least a 70% of the shares of Transfer Stock then held by all of the Key Holders who are then providing services to the Company as officers, employees or
consultants, and (c) the holders of at least a majority of the shares of Common Stock issued or issuable upon conversion of the then outstanding shares of Series C Preferred Stock held by the Investors (voting as a single class and on an as-converted basis). Any amendment, modification, termination or waiver so effected shall be binding upon the Company, the Investors, the Key Holders and all of their respective successors and permitted assigns
whether or not such party, assignee or other shareholder entered into or approved such amendment, modification, termination or waiver. Notwithstanding the foregoing, Schedule A hereto may be amended by the Company from time to time in accordance
with the Purchase Agreement to add information regarding Additional Purchasers (as defined in the Purchase Agreement) without the consent of the other parties hereto. The Company shall give prompt written notice of any amendment, modification or
termination hereof or waiver hereunder to any party hereto that did not consent in writing to such amendment, modification, termination or waiver. No waivers of or exceptions to any term, condition or provision of this Agreement, in any one or more
instances, shall be deemed to be, or construed as, a further or continuing waiver of any such term, condition or provision. 

  
 11 

 6.9    Assignment of Rights. 

(a)    The terms and conditions of this Agreement shall inure to the benefit of and be binding upon the respective
successors and permitted assigns of the parties. Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective successors and permitted assigns any rights, remedies,
obligations, or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement. 

(b)    Any successor or permitted assignee of any Key Holder, including any Prospective Transferee who purchases shares
of Transfer Stock in accordance with the terms hereof, shall deliver to the Company and the Investors, as a condition to any transfer or assignment, a counterpart signature page hereto pursuant to which such successor or permitted assignee shall
confirm their agreement to be subject to and bound by all of the provisions set forth in this Agreement that were applicable to the predecessor or assignor of such successor or permitted assignee. 

(c)    The rights of the Investors hereunder are not assignable without the Company’s written consent (which shall
not be unreasonably withheld, delayed or conditioned), except by an Investor to any Affiliate, it being acknowledged and agreed that any such assignment, including an assignment contemplated by the preceding clause shall be subject to and
conditioned upon any such assignee’s delivery to the Company and the other Investors of a counterpart signature page hereto pursuant to which such assignee shall confirm their agreement to be subject to and bound by all of the provisions set
forth in this Agreement that were applicable to the assignor of such assignee. 
 (d)    Except in connection with an
assignment by the Company by operation of law to the acquirer of the Company, the rights and obligations of the Company hereunder may not be assigned under any circumstances. 

6.10    Severability. The invalidity or unenforceability of any provision hereof shall in no way affect the
validity or enforceability of any other provision. 
 6.11    Additional Investors. Notwithstanding anything to
the contrary contained herein, if the Company issues additional shares of the Company’s Series C Preferred Stock after the date hereof, any purchaser of such shares of Series C Preferred Stock may become a party to this Agreement by executing
and delivering an additional counterpart signature page to this Agreement and thereafter shall be deemed an “Investor” for all purposes hereunder. 

6.12    Titles and Subtitles. The titles and subtitles used in this Agreement are used for convenience only and are
not to be considered in construing or interpreting this Agreement. 
 6.13    Counterparts. This Agreement may be
executed in two (2) or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (including pdf or any
electronic signature complying with the U.S. federal ESIGN Act of 2000, 

  
 12 

 
e.g., www.docusign.com) or other transmission method and any counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.

 6.14    Aggregation of Stock. All shares of Capital Stock held or acquired by Affiliated entities or persons
shall be aggregated together for the purpose of determining the availability of any rights under this Agreement and such Affiliated persons may apportion such rights as among themselves in any manner they deem appropriate. 

6.15    Specific Performance. In addition to any and all other remedies that may be available at law in the event
of any breach of this Agreement, each Investor shall be entitled to specific performance of the agreements and obligations of the Company and the Key Holders hereunder and to such other injunction or other equitable relief as may be granted by a
court of competent jurisdiction. 
 [Remainder of Page Intentionally Left Blank] 

  
 13 

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

			
	DERMTECH, INC.
		
	By:	 	 /s/ John Dobak

	Name:	 	John Dobak
	Title:	 	Chief Executive Officer

  

SIGNATURE PAGE TO RIGHT OF FIRST
REFUSAL AND CO-SALE AGREEMENT 

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

			
	INVESTOR:
	
	RTW MASTER FUND, LTD
		
	By:	 	 /s/ Roderick Wong

	Name: Roderick Wong
	Title: Director
	
	RTW INNOVATION MASTER FUND, LTD
		
	By:	 	 /s/ Roderick Wong

	Name: Roderick Wong
	Title: Director

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

			
	INVESTOR:
	
	Darakev LP
		
	By:	 	 /s/ Kevin Wechter

	Name: Kevin Wechter
	Title: CEO of Darakev Management LLC its GP

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

			
	INVESTOR:
	
	Paulson DermTech Investments LLC
		
	By:	 	 /s/ Starla Goff

	Name: Starla Goff
	Title: Officer of the Managing Member

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

			
	INVESTOR:
	
	Paulson DermTech Investments III LLC
		
	By:	 	 /s/ Starla Goff

	Name: Starla Goff
	Title: Officer of the Managing Member

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

			
	INVESTOR:
	
	Paulson DermTech Investments II LLC
		
	By:	 	 /s/ Starla Goff

	Name: Starla Goff
	Title: Officer of the Managing Member

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

	
	INVESTOR:
	
	 /s/ Jeremy and Junko Teraoka

	Jeremy and Junko Teraoka

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

			
	INVESTOR:
	
	Irwin and Joan Jacobs Family Trust 6-2-80
		
	By:	 	 /s/ Irwin M. Jacobs

	Name: Irwin M. Jacobs
	Title: Trustee

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

			
	INVESTOR:
	
	Roberta Feuerstein Trust DTD 7-9-83
		
	By:	 	 /s/ Roberta Feuerstein

	Name: Roberta Feuerstein Trust DTD 7-9-83
	Title: Trustee

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

			
	INVESTOR:
	
	 /s/ Elliot Feuerstein

	Elliot Feuerstein
	
	Brett Feuerstein Children’s Trust
		
	By:	 	 /s/ Elliot Feuerstein

	Name: Elliot Feuerstein
	Title: Trustee
	
	Michael Feuerstein Children’s Trust
		
	By:	 	 /s/ Elliot Feuerstein

	Name: Elliot Feuerstein
	Title: Trustee
	
	Elliot Feuerstein Trust DTD 5-14-83
		
	By:	 	 /s/ Elliot Feuerstein

	Name: Elliot Feuerstein
	Title: Trustee
	
	Mesa Shopping Center East LLC
		
	By:	 	 /s/ Elliot Feuerstein

	Name: Elliot Feuerstein
	Title: Manager
	
	Mesa Shopping Center East LLC
		
	By:	 	 /s/ Elliot Feuerstein

	Name: Elliot Feuerstein
	Title: Manager
	
	Mira Mesa Shopping Center West LLC
		
	By:	 	 /s/ Elliot Feuerstein

	Name: Elliot Feuerstein
	Title: Manager
	
	Mira Mesa Shopping Center LLC
		
	By:	 	 /s/ Elliot Feuerstein

	Name: Elliot Feuerstein
	Title: Manager

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

	
	KEY HOLDER:
	
	/s/ Zuxu Yao
	Zuxu Yao

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

	
	KEY HOLDER:
	
	/s/ Darryl A. Garrison
	Darryl A. Garrison

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

	
	KEY HOLDER:
	
	/s/ James A. Rock
	James A. Rock

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

	
	KEY HOLDER:
	
	/s/ Sarah Dion
	Sarah Dion

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

	
	KEY HOLDER:
	
	/s/ Herm Rosenman
	Herm Rosenman

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

	
	KEY HOLDER:
	
	/s/ Carl C. Peck
	Carl C. Peck

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

	
	KEY HOLDER:
	
	/s/ Burkhard Jansen
	Burkhard Jansen

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

	
	KEY HOLDER:
	
	/s/ John Dobak
	John Dobak

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

	
	KEY HOLDER:
	
	/s/ Gary E. Jacobs
	Gary E. Jacobs

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

	
	KEY HOLDER:
	
	/s/ Gene Salkind, M.D.
	Gene Salkind, M.D.

 IN WITNESS WHEREOF, the parties have executed this Right of First Refusal and Co-Sale Agreement as of the date first written above. 
  

	
	KEY HOLDER:
	
	/s/ Scott Pancoast
	Scott Pancoast

 SCHEDULE A 

INVESTORS 
 The Jacobs Investment Company
LLC 
 Gary Jacobs 
 Peter Brundage 

Gene Salkind, M.D. 
 KT4 Partners LLC 

STOTSKY, Michael S. M.D. Trustee FBO Michael S. Stotsky MPP 

Dennis Logue 
 MERG Holdings Pty Ltd. 

Frederick McCarthy 
 Elliott Feuerstein 

Elliot Feuerstein, Trustee FBO Michael Feuerstein, Feuerstein Children’s Trust UTD
3-15-89 
 Elliot Feuerstein, Trustee FBO Brett Feuerstein, Feuerstein
Children’s Trust UTD 3-15-89 
 Michael H. Good, M.D. 

James Goode 
 Elias Alemesalassie 

Michael McGilveny 
 Daniel Einhorn and Emily Feldman Einhorn Trust
of 1994 
 Patrick E. Pellecchia 
 Gregory A. Erickson 

Touchstone Investments Defined Benefit Plan Pension Trust: Gregory A. Erickson, Trustee 

Elliot Feuerstein, Trustee for Elliot Feuerstein Trust UTD 5-14-82 

Darakev LP, a Texas limited partnership 
 John Dobak 

Pacific Equity Ventures, L.P., a California limited partnership 

Chitayat Family Gift Trust dated 12/19/2003 
 DLA Piper 

WS Investment Company, LLC (2013A) 
 Adams Family Trust, UAD 6-34-94 
 Dana Donovon 

Harmon Spolan 
 Jack L. Stahl 

Jill M. Olson 
 Likipi Holding SA 

Michael Sanders Stotsky Trust 
 Steven M. Wetzner 

Leon Wagner 
 Ian Katz 

James Schwering 
 Paulson DermTech Investments, LLC 

Keith Gelles 

 Bradley Karp 

Jacob M. Gamble 
 Kingdom Partners LLC 

Bradley C. & Belinda Karp 
 UBS Financial Services Inc. 

FBO David W. Carey Traditional IRA 
 Louis B. Cushman 

Irwin and Joan Jacobs Family Trust 6-2-80 

Gregory A. Erickson 
 Pacific Equity Ventures LP 

William C. Skelsey & Maral K. Skelsey JTROS 
 Paulson
DermTech Investment III, LLC 
 Mira Mesa Shopping Center LLC 

Mira Mesa Shopping Center, -West, LLC 
 Mesa Shopping Center, -
East, LLC 
 Elliot Feuerstein Trust DTD 5-14-83 

Roberta Feuerstein Trust DTD 7-9-83 

Darakev, L.P. 
 RTW Master Fund, LTD 

RTW Innovation Master Fund, LTD 

 SCHEDULE B 

KEY HOLDERS 
 Gary Jacobs 

Carl Peck, M.D. 
 John Dobak 

Gene Salkind, M.D. 
 Scott Pancoast 

Steven Kemper 
 Herm Rosenman 

Burkhard Jansen 
 Zuxu Yao 

Sarah Dion 
 Darryl Garrison 

Jim RockEX-10.25

 Exhibit 10.25 

FORM OF LOCK-UP AGREEMENT 

THIS LOCK-UP AGREEMENT (this “Agreement”), dated as of
             , 2019, is made and entered into by and among Constellation Alpha Capital Corp., a Delaware corporation (the “Company,” and prior to the Company’s
domestication as a Delaware corporation, the “BVI Company”) and the undersigned parties listed under the heading “Holders” on the signature pages hereto (each such party, a “Holder” and collectively the
“Holders”). 
 WHEREAS, the Holders are acquiring an aggregate of [●] shares of common stock of the Company, par
value $0.001 (“Common Stock”) per share in exchange for their outstanding shares of capital stock of DermTech, Inc., a Delaware corporation (“DermTech”), on or about the date hereof, pursuant to that certain
Agreement and Plan of Merger, dated as of May 29, 2019, by and among the BVI Company, DT Merger Sub, Inc., a Delaware corporation (“Merger Sub”), and DermTech, whereby Merger Sub will merge with and into DermTech, with DermTech
surviving as a wholly owned subsidiary of the Company (the “Merger”). 
 NOW, THEREFORE, in consideration of the mutual
covenants and agreements set forth herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending to be legally bound, hereby agree as follows: 

1. LOCK-UP. 

1.1 Lock-Up. Each Holder agrees that, during the period commencing on the date hereof and
continuing to and including the date 180 days after the date of the closing of the Merger (the “Restricted Period”), the Holder shall not (i) sell, offer to sell, contract or agree to sell, hypothecate, pledge, grant any option
to purchase or otherwise dispose of or agree to dispose of, directly or indirectly, or establish or increase a put equivalent position or liquidate or decrease a call equivalent position within the meaning of Section 16 of the Securities
Exchange Act of 1934, as amended, and the rules and regulations of the Commission promulgated thereunder, with respect to any shares of Common Stock or any securities convertible into or exercisable or exchangeable for shares of Common Stock,
whether now owned or hereafter acquired by the undersigned or with respect to which the undersigned has or hereafter acquires the power of disposition (collectively, the “Lock-Up Securities”),
(ii) enter into any swap or other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of any Lock-Up Securities owned by him, her or it, whether any such
transaction is to be settled by delivery of such securities, in cash or otherwise, or (iii) publicly announce any intention to effect any transaction specified in clause (i) or (ii). 

1.2 Exceptions. The provisions of Section 1.1 shall not apply to: 

 

	 	1.1.1	 transactions relating to shares of Common Stock acquired in open market transactions; 

 

	 	1.1.2	 transfers of shares of Common Stock or any security convertible into or exercisable or exchangeable for Common
Stock as a bona fide gift; 

	 	1.1.3	 transfers of shares of Common Stock to a trust, or other entity formed for estate planning purposes for the
primary benefit of the spouse, domestic partner, parent, sibling, child or grandchild of the undersigned or any other person with whom the undersigned has a relationship by blood, marriage or adoption not more remote than first cousin;

  

	 	1.1.4	 transfers by will or intestate succession upon the death of the undersigned; 

 

	 	1.1.5	 the transfer of shares of Common Stock pursuant to a qualified domestic order or in connection with a divorce
settlement; 

  

	 	1.1.6	 if the undersigned is a corporation, partnership (whether general, limited or otherwise), limited liability
company, trust or other business entity, (i) transfers to another corporation, partnership, limited liability company, trust or other business entity that controls, is controlled by or is under common control or management with the undersigned,
or (ii) distributions of shares of Common Stock to partners, limited liability company members or stockholders of the undersigned; 

  

	 	1.1.7	 transfers to the Company’s officers, directors or their affiliates; 

 

	 	1.1.8	 pledges of shares of Common Stock as security or collateral in connection with any borrowing or the incurrence
of any indebtedness by any Holder (provided that no transfers of such shares may be effected as a result of any such pledge prior to the end of the Restricted Period); and 

 

	 	1.1.9	 pursuant to a bona fide third-party tender offer, merger, stock sale, recapitalization, consolidation or
other transaction involving a Change in Control of the Company, provided that in the event that such tender offer, merger, recapitalization, consolidation or other such transaction is not completed, the Common Stock subject to this Lock-Up Agreement shall remain subject to this Lock-up Agreement. For purposes of this Section 1.1.9, a “Change of Control” means the transfer (whether by
tender offer, merger, stock purchase, consolidation or other similar transaction), in one transaction or a series of related transactions, to a person or group of affiliated persons of the Company’s voting securities if, after such transfer,
such person or group of affiliated persons would hold more than 50% of outstanding voting securities of the Company (or surviving entity) or would otherwise have the power to control the board of directors of the Company or to direct the operations
of the Company. 

 Provided, that in the case of any transfer or distribution pursuant to Sections 1.2.2 through
1.2.7, each donee, distributee or other transferee shall agree in writing, in form and substance reasonably satisfactory to the Company, to be bound by the provisions of this Agreement. 

  

 2. MISCELLANEOUS. 

2.1 Assignment; No Third-Party Beneficiaries. This Agreement and the rights, duties and obligations of the Company hereunder may not be
assigned or delegated by the Company in whole or in part. This Agreement and the rights, duties and obligations of the Holders may be assigned or delegated by such Holder only in conjunction with and to the extent of any transfer of Lock-Up Securities by any such Holder in accordance with the terms of this Agreement. This Agreement and the provisions hereof shall be binding upon and shall inure to the benefit of each of the parties and the
permitted assigns of the applicable Holder or of any assignee of such applicable Holder. This Agreement is not intended to confer any rights or benefits on any persons that are not party hereto other than as expressly set forth in this
Section 2.1. No assignment by any party hereto of such party’s rights, duties and obligations hereunder shall be binding upon or obligate the Company unless and until the Company shall have received (i) written notice of such
assignment and (ii) the written agreement of the assignee, in a form reasonably satisfactory to the Company, to be bound by the terms and provisions of this Agreement (which may be accomplished by an addendum or certificate of joinder to this
Agreement). 
 2.2 Notices. All notices, demands, requests, consents, approvals or other communications required or permitted to be
given hereunder or which are given with respect to this Agreement shall be in writing and shall be personally served, delivered by reputable air courier service with charges prepaid, or transmitted by hand delivery,
e-mail, telegram, telex or facsimile, addressed as set forth below, or to such other address as such party shall have specified most recently by written notice. Notice shall be deemed given on the date of
service or transmission if personally served or transmitted by telegram, telex or facsimile; provided, that if such service or transmission is not on a business day or is after normal business hours, then such notice shall be deemed given on the
next business day. Notice otherwise sent as provided herein shall be deemed given on the next business day following timely delivery of such notice to a reputable air courier service with an order for next-day
delivery. 
 To the Company: 

11099 N. Torrey Pines Road, #100 

La Jolla, California 92037 

Telephone: (858) 291-7505 

Attention: Steven Kemper 
 Email:
skemper@dermtech.com 
 with a copy to: 

Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. 

3580 Carmel Mountain Road, Suite 300 

San Diego, California 92130 

Telephone No.: (858) 314-1515 

Attention: Jeremy Glaser 
 Email:
JDGlaser@mintz.com 

  

 To all other Holders, to such address as set forth beneath such Holder’s signature on
the signature page hereto. 
 2.3 Severability. This Agreement shall be deemed severable, and the invalidity or unenforceability of
any term or provision hereof shall not affect the validity or enforceability of this Agreement or of any other term or provision hereof. Furthermore, in lieu of any such invalid or unenforceable term or provision, the parties hereto intend that
there shall be added as a part of this Agreement a provision as similar in terms to such invalid or unenforceable provision as may be possible that is valid and enforceable. 

2.4 Counterparts. This Agreement may be executed in multiple counterparts, each of which shall be deemed an original, and all of which
taken together shall constitute one and the same instrument. 
 2.5 Entire Agreement. This Agreement (including all agreements
entered into pursuant hereto and all certificates and instruments delivered pursuant hereto and thereto) constitute the entire agreement of the parties with respect to the subject matter hereof and supersede all prior and contemporaneous agreements,
representations, understandings, negotiations and discussions between the parties, whether oral or written. 
 2.6 Titles and
Headings. Titles and headings of sections of this Agreement are for convenience only and shall not affect the construction of any provision of this Agreement. 

2.7 Governing Law. This Agreement shall be governed by, interpreted under, and construed in accordance with the internal laws of the
State of New York applicable to agreements made and to be performed within the State of New York, without giving effect to any choice-of-law provisions thereof that
would compel the application of the substantive laws of any other jurisdiction. 
 2.8 Waiver of Trial by Jury. Each party hereby
irrevocably and unconditionally waives the right to a trial by jury in any action, suit, counterclaim or other proceeding (whether based on contract, tort or otherwise) arising out of, connected with or relating to this Agreement, the transactions
contemplated hereby, or the actions of the Holders in the negotiation, administration, performance or enforcement hereof. 
 [REMAINDER OF
PAGE INTENTIONALLY LEFT BLANK] 

  

 IN WITNESS WHEREOF, the parties have caused this
Lock-Up Agreement to be executed and delivered by their duly authorized representatives as of the date first written above. 

 

			
	COMPANY:
	
	CONSTELLATION ALPHA CAPITAL
	CORP., a Delaware corporation
		
	By:	 	
                    

	Name:	 	
	Title:	 	

  
 [Signature page to
Lock-Up Agreement] 

 IN WITNESS WHEREOF, the parties have caused this
Lock-Up Agreement to be executed and delivered by their duly authorized representatives as of the date first written above. 

 

			
	HOLDER:
	
	[ENTITY HOLDER]
		
	By:	 	
                    

	Name:	 	
	Title:	 	
	Address:	 	

  
 [Signature page to
Lock-Up Agreement] 

 IN WITNESS WHEREOF, the parties have caused this
Lock-Up Agreement to be executed and delivered by their duly authorized representatives as of the date first written above. 

 

			
	HOLDER:	 	
	
	  

	[INDIVIDUAL NAME]	 	
	Address:	 	

  
 [Signature page to
Lock-Up Agreement]

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