Document:

EX-10.20

 Exhibit 10.20 

LOAN AGREEMENT 
 Dated
as of October 13, 2017 
 between 

SI-BONE, INC. 

(as Borrower), 
 and

 BIOPHARMA CREDIT INVESTMENTS IV SUB LP 

(as Lender) 

 Table of Contents 

 

									
	 	 	 	  	 	  	Page	 
			
	1.	 	ACCOUNTING AND OTHER TERMS	  	 	1	 
			
	2.	 	LOANS AND TERMS OF PAYMENT	  	 	1	 
				
		 	2.1.	  	Promise to Pay	  	 	1	 
				
		 	2.2.	  	Term Loans	  	 	1	 
				
		 	2.3.	  	Payment of Interest on the Credit Extension	  	 	2	 
				
		 	2.4.	  	Expenses	  	 	3	 
				
		 	2.5.	  	Requirements of Law; Increased Costs; Mitigation	  	 	3	 
				
		 	2.6.	  	Taxes; Withholding, etc.	  	 	4	 
				
		 	2.7.	  	Additional Consideration	  	 	5	 
				
		 	2.8.	  	Evidence of Debt; Register; Lender’s Books and Records; Term Loan Note	  	 	5	 
			
	3.	 	CONDITIONS OF LOANS	  	 	6	 
				
		 	3.1.	  	Conditions Precedent to Tranche A Loan	  	 	6	 
				
		 	3.2.	  	Conditions Precedent to Tranche B Loan	  	 	8	 
				
		 	3.3.	  	Additional Conditions Precedent to Term Loans	  	 	8	 
				
		 	3.4.	  	Covenant to Deliver	  	 	8	 
				
		 	3.5.	  	Procedures for Borrowing	  	 	8	 
			
	4.	 	REPRESENTATIONS AND WARRANTIES	  	 	9	 
				
		 	4.1.	  	Due Organization, Authorization; Power and Authority	  	 	9	 
				
		 	4.2.	  	Equity Interests and Ownership	  	 	9	 
				
		 	4.3.	  	No Conflict; Government Consents	  	 	9	 
				
		 	4.4.	  	Binding Obligation	  	 	9	 
				
		 	4.5.	  	Collateral; Intellectual Property	  	 	10	 
				
		 	4.6.	  	Adverse Proceedings, etc.	  	 	13	 
				
		 	4.7.	  	Financial Statements; Material Contracts; No Material Adverse Change; Books and Records	  	 	13	 
				
		 	4.8.	  	Solvency	  	 	14	 
				
		 	4.9.	  	Payment of Taxes	  	 	14	 
				
		 	4.10.	  	Environmental Matters	  	 	15	 
				
		 	4.11.	  	Material Contracts	  	 	15	 
				
		 	4.12.	  	Regulatory Compliance	  	 	15	 
				
		 	4.13.	  	Margin Stock	  	 	15	 
				
		 	4.14.	  	Subsidiaries; Investments; Affiliate Transactions	  	 	16	 
				
		 	4.15.	  	Employee Matters	  	 	16	 
				
		 	4.16.	  	Use of Proceeds	  	 	16	 
				
		 	4.17.	  	Full Disclosure	  	 	16	 

  
 -i- 

 Table of Contents 

(continued) 
  

									
	 	 	 	  	 	  	Page	 
				
		 	4.18.	  	FCPA; Patriot Act; OFAC	  	 	16	 
				
		 	4.19.	  	Insurance Contracts	  	 	17	 
				
		 	4.20.	  	Health Care Matters	  	 	17	 
				
		 	4.21.	  	Regulatory Approvals.	  	 	19	 
				
		 	4.22.	  	Supply and Manufacturing	  	 	20	 
				
		 	4.23.	  	Additional Representations and Warranties	  	 	20	 
			
	5.	 	AFFIRMATIVE COVENANTS	  	 	21	 
				
		 	5.1.	  	Government Compliance	  	 	21	 
				
		 	5.2.	  	Financial Statements, Compliance Certificates; Notices; Reports	  	 	21	 
				
		 	5.3.	  	Inventory; Returns; Maintenance of Properties	  	 	24	 
				
		 	5.4.	  	Taxes; Pensions	  	 	24	 
				
		 	5.5.	  	Insurance	  	 	25	 
				
		 	5.6.	  	Operating Accounts	  	 	25	 
				
		 	5.7.	  	Protection of Intellectual Property Rights	  	 	25	 
				
		 	5.8.	  	Litigation Cooperation	  	 	26	 
				
		 	5.9.	  	Access to Collateral; Books and Records; Audits	  	 	26	 
				
		 	5.10.	  	Use of Proceeds	  	 	26	 
				
		 	5.11.	  	Environmental Disclosure	  	 	26	 
				
		 	5.12.	  	Minimum Liquidity	  	 	27	 
				
		 	5.13.	  	Further Assurances	  	 	27	 
				
		 	5.14.	  	Additional Collateral; Guarantors.	  	 	28	 
				
		 	5.15.	  	Formation or Acquisition of Subsidiaries	  	 	28	 
				
		 	5.16.	  	Post-Closing Requirements	  	 	29	 
				
		 	5.17.	  	Commercialization	  	 	29	 
				
		 	5.18.	  	Lender Meetings	  	 	29	 
			
	6.	 	NEGATIVE COVENANTS	  	 	29	 
				
		 	6.1.	  	Dispositions	  	 	29	 
				
		 	6.2.	  	Changes in Business, Management or Business Locations	  	 	31	 
				
		 	6.3.	  	Mergers, Acquisitions	  	 	31	 
				
		 	6.4.	  	Indebtedness	  	 	32	 
				
		 	6.5.	  	Encumbrance	  	 	32	 
				
		 	6.6.	  	No Further Negative Pledges; Negative Pledge	  	 	32	 
				
		 	6.7.	  	Maintenance of Collateral Accounts	  	 	34	 
				
		 	6.8.	  	Distributions; Investments	  	 	34	 
				
		 	6.9.	  	Restrictions on Subsidiary Distributions	  	 	34	 

  
 -ii- 

 Table of Contents 

(continued) 
  

									
	 	 	 	  	 	  	Page	 
				
		 	6.10.	  	Transactions with Affiliates	  	 	36	 
				
		 	6.11.	  	Subordinated Debt	  	 	36	 
				
		 	6.12.	  	Amendments or Waivers of Organizational Documents	  	 	37	 
				
		 	6.13.	  	Fiscal Year	  	 	37	 
				
		 	6.14.	  	Compliance	  	 	37	 
				
		 	6.15.	  	Compliance with Anti-Terrorism Laws	  	 	37	 
				
		 	6.16.	  	Current Company IP Agreements and Material Contracts	  	 	37	 
				
		 	6.17.	  	Minimum Net Sales; Minimum Consolidated EBITDA	  	 	38	 
			
	7.	 	EVENTS OF DEFAULT	  	 	39	 
				
		 	7.1.	  	Payment Default	  	 	39	 
				
		 	7.2.	  	Covenant Default	  	 	39	 
				
		 	7.3.	  	Material Adverse Change	  	 	40	 
				
		 	7.4.	  	Attachment; Levy; Restraint on Business	  	 	40	 
				
		 	7.5.	  	Insolvency	  	 	40	 
				
		 	7.6.	  	Other Agreements	  	 	40	 
				
		 	7.7.	  	Judgments	  	 	41	 
				
		 	7.8.	  	Misrepresentations	  	 	41	 
				
		 	7.9.	  	Loan Documents; Collateral	  	 	41	 
				
		 	7.10.	  	Subordinated Debt	  	 	41	 
				
		 	7.11.	  	Change in Control	  	 	41	 
				
		 	7.12.	  	ERISA Event	  	 	41	 
			
	8.	 	RIGHTS AND REMEDIES UPON AN EVENT OF DEFAULT	  	 	42	 
				
		 	8.1.	  	Rights and Remedies	  	 	42	 
				
		 	8.2.	  	Power of Attorney	  	 	43	 
				
		 	8.3.	  	[Reserved.]	  	 	43	 
				
		 	8.4.	  	Application of Payments and Proceeds upon Default	  	 	43	 
				
		 	8.5.	  	Lender’s Liability for Collateral	  	 	43	 
				
		 	8.6.	  	No Waiver; Remedies Cumulative	  	 	43	 
				
		 	8.7.	  	Demand Waiver; Makewhole Amount; Prepayment Premium	  	 	43	 
			
	9.	 	NOTICES	  	 	44	 
			
	10.	 	CHOICE OF LAW, VENUE AND JURY TRIAL WAIVER	  	 	45	 
			
	11.	 	GENERAL PROVISIONS	  	 	45	 
				
		 	11.1.	  	Successors and Assigns	  	 	45	 
				
		 	11.2.	  	Indemnification; Costs and Expenses	  	 	46	 
				
		 	11.3.	  	Severability of Provisions	  	 	47	 

  
 -iii- 

 Table of Contents 

(continued) 
  

									
	 	 	 	  	 	  	Page	 
				
		 	11.4.	  	Correction of Loan Documents	  	 	47	 
				
		 	11.5.	  	Amendments; Waivers; Integration	  	 	47	 
				
		 	11.6.	  	Counterparts	  	 	47	 
				
		 	11.7.	  	Survival	  	 	47	 
				
		 	11.8.	  	Confidentiality	  	 	47	 
				
		 	11.9.	  	Attorneys’ Fees, Costs and Expenses	  	 	48	 
				
		 	11.10.	  	Right of Set-Off	  	 	48	 
				
		 	11.11.	  	Marshalling; Payments Set Aside	  	 	48	 
				
		 	11.12.	  	Electronic Execution of Documents	  	 	48	 
				
		 	11.13.	  	Captions	  	 	48	 
				
		 	11.14.	  	Construction of Agreement	  	 	48	 
				
		 	11.15.	  	Third Parties	  	 	48	 
				
		 	11.16.	  	No Fiduciary Duty	  	 	48	 
			
	12.	 	LENDER AGREEMENTS	  	 	49	 
				
		 	12.1.	  	Intercreditor Agreement	  	 	49	 
				
		 	12.2.	  	Non-Disturbance Agreement	  	 	49	 
			
	13.	 	DEFINITIONS	  	 	49	 
				
		 	13.1.	  	Definitions	  	 	49	 

  
 -iv- 

 LOAN AGREEMENT 

THIS LOAN AGREEMENT (this “Agreement”), dated as of October 13, 2017 (the “Effective Date”)
by and among SI-BONE, INC., a Delaware corporation (“Borrower”), and BIOPHARMA CREDIT INVESTMENTS IV SUB LP, a Cayman Islands limited partnership (“Lender”), provides
the terms on which Lender shall make, and Borrower shall repay, the Credit Extensions (as hereinafter defined). The parties hereto agree as follows: 

1. ACCOUNTING AND OTHER TERMS 

Except as otherwise expressly provided herein, all accounting terms not otherwise defined in this Agreement shall have the meanings assigned to them in
conformity with Applicable Accounting Standards. Calculations and determinations must be made following Applicable Accounting Standards. No change in the accounting principles used in the preparation of any financial statement hereafter adopted by
Borrower (including any change in Applicable Accounting Standards that would require leases that would be classified as operating leases under Applicable Accounting Standards on the Tranche A Closing Date to be reclassified as capital leases, it
being understood and agreed by Borrower and Lender that all leases will be accounted for without giving effect to Topic 842 (Leases) of the Financial Accounting Standards Board) shall be given effect for purposes of measuring compliance with any
provision of Section 5.12 or Section 6 unless Borrower and Lender agree to modify such provisions to reflect such changes in Applicable Accounting Standards and, unless such provisions are so
modified, all financial statements, Compliance Certificates and similar documents provided hereunder shall be provided together with a reconciliation between the calculations and amounts set forth therein before and after giving effect to such
change in Applicable Accounting Standards. Capitalized terms not otherwise defined in this Agreement shall have the meanings set forth in Section 13. All other terms contained in this Agreement, unless otherwise indicated,
shall have the meaning provided by the Code to the extent such terms are defined therein. All references to “Dollars” or “$” are United States Dollars, unless otherwise noted. 

2. LOANS AND TERMS OF PAYMENT 

2.1. Promise to Pay. 

Borrower hereby unconditionally promises to pay Lender, the outstanding principal amount of all of the Term Loans advanced to Borrower by
Lender and accrued and unpaid interest thereon and any other amounts due hereunder as and when due in accordance with this Agreement. 

2.2. Term Loans. 
 (a)
Availability. Subject to the terms and conditions of this Agreement (including Sections 3.1, 3.2 and 3.3): 

(i) Tranche A Loan. Lender agrees to make a term loan to Borrower on the Tranche A Closing Date in the principal amount
(the “Tranche A Loan Amount”) of Forty Million Dollars ($40,000,000.00) (the “Tranche A Loan”); and 

(ii) Tranche B Loan. At Borrower’s option, Lender agrees to make a term loan to Borrower on the Tranche B Closing
Date in a principal amount equal to the Tranche B Loan Amount (the “Tranche B Loan”). 
 After repayment, no Term Loan may be re-borrowed. 
 (b) Repayment. Borrower shall make nine (9) equal quarterly payments of
principal of the Term Loans commencing on the Payment Date that is the 36th-month anniversary of the Tranche A Closing Date. All unpaid principal with respect to the Term Loans (and, for the
avoidance of doubt, all accrued and unpaid interest, all due and unpaid Lender Expenses and any other amounts payable under the Loan Documents) is due and payable in full on the Term Loan Maturity Date. The Term Loans may be prepaid only in
accordance with Section 2.2(c), except as provided in Section 8.1. 
 (c) Prepayment of Term
Loans. 

  
 1 

 (i) From and after the Tranche A Closing Date, Borrower shall have the
option, at any time, to prepay, in whole but not in part, the Term Loans advanced by Lender under this Agreement, provided that (A) Borrower provides written notice to Lender of its election (which shall be irrevocable unless Lender
otherwise consents in writing) to prepay all of the Term Loans at least five (5) Business Days prior to such prepayment, in an amount equal to the sum of the unpaid principal amount prepaid and any accrued and unpaid interest on the principal
amount prepaid and (B) such prepayment shall be accompanied by any amounts payable pursuant to Section 2.2(e) or Section 2.2(f) (as applicable) and all other amounts payable or accrued and not
yet paid under this Agreement and the other Loan Documents. 
 (ii) Upon a Change of Control, Borrower shall promptly, and in
any event no later than two (2) Business Days after the consummation of such Change of Control, notify Lender in writing of the occurrence of a Change of Control, which notice shall include reasonable detail as to the nature, timing and other
circumstances of such Change of Control (such notice, a “Change of Control Notice”). Borrower shall prepay all of the Term Loans in full, no later than ten (10) Business Days after delivery to Lender of the Change of Control
Notice, in an amount equal to (A) the sum of all unpaid principal and any accrued and unpaid interest with respect to the Term Loans, plus (B) any amounts payable pursuant to Section 2.2(e) or
Section 2.2(f) (as applicable) and all other amounts payable or accrued and not yet paid under this Agreement and the other Loan Documents. 

(d) Prepayment Application. Any prepayment by Borrower pursuant Section 2.2(c) shall be accompanied by, and
any prepayment by Borrower pursuant to Section 6.1(o) or Section 6.17(c) shall include, accrued and unpaid interest on the principal amount to be prepaid to the date of payment in full. Any
prepayment of the Term Loans pursuant to Section 2.2(c), Section 6.1(o) or Section 6.17(c) (together with the accompanying Makewhole Amount that is payable pursuant to
Section 2.2(e), if applicable, and the Prepayment Premium that is payable pursuant to Section 2.2(f)) shall be paid to Lender for application to the Obligations in the following order: (i) first,
to due and unpaid Lender Expenses, (ii) second, to accrued and unpaid interest at the Default Rate, (iii) third, to accrued and unpaid interest at the non-Default Rate, (iv) fourth, to the
applicable Prepayment Premium; (v) fifth, to the Makewhole Amount, if applicable, (vi) sixth, to the outstanding principal amount of the Term Loans and (vii) seventh, to any remaining amounts then due and payable hereunder. 

(e) Makewhole Amount. Any prepayment of the Term Loans by Borrower occurring on or prior to the 30th-month anniversary of the Tranche A Closing Date (i) pursuant to Section 2.2(c), Section 6.1(o) or Section 6.17(c)
or (ii) as a result of the acceleration of the Term Loan Maturity Date pursuant to Section 8.1(a) shall, in any such case, be accompanied by payment of the Makewhole Amount. 

(f) Prepayment Premium. Any prepayment of the Term Loans by Borrower (i) pursuant to Section 2.2(c),
Section 6.1(o) or Section 6.17(c) or (ii) as a result of the acceleration of the Term Loan Maturity Date pursuant to Section 8.1(a) shall, in any such case, be
accompanied by payment of the applicable Prepayment Premium. 
 2.3. Payment of Interest on the Credit Extension. 

(a) Interest Rate; 360 Day Year. 

(i) Subject to Section 2.3(b), the principal amount outstanding under the Term Loans shall accrue
interest at a fixed per annum rate equal to eleven and one-half percent (11.50%) per annum (which rate, subject to clause (b) below, shall be fixed for the duration of the Term Loans), which
interest shall be payable quarterly in arrears in accordance with this Section 2.3. 
 (ii)
Interest shall accrue on each Term Loan commencing on, and including, the day on which such Term Loan is made, and shall accrue on each Term Loan, or any portion thereof, for the day on which such Term Loan or such portion is paid. Interest shall be
computed on the basis of a year of 360 days and the actual number of days elapsed. 
 (b) Default Rate. Immediately upon the
occurrence and during the continuance of an Event of Default (and without notice to Borrower or demand by Lender for payment thereof), the Obligations shall bear interest at a rate per annum which is five percentage points (5.00%) above the rate
that is otherwise applicable thereto (the “Default Rate”), and such interest shall be payable entirely in cash on demand of Lender. Payment or acceptance of the increased interest rate provided in this
Section 2.3(b) is not a permitted alternative to timely payment and shall not constitute a waiver of any Event of Default or otherwise prejudice or limit any rights or remedies of Lender. 

 

  
 2 

 (c) Payments. Except as otherwise expressly provided herein, all loan payments by
Borrower hereunder shall be made to such bank account of Lender as Lender may designate by notice from time to time to Borrower on the date specified herein. Unless otherwise provided, interest is payable quarterly on the Payment Date of each
calendar quarter. Payments of principal or interest received after 2:00 p.m. on such date are considered received at the opening of business on the next Business Day. When a payment is due on a day that is not a Business Day, the payment is due the
next Business Day and additional fees or interest, as applicable, shall continue to accrue until paid. All payments to be made by Borrower hereunder or under any other Loan Document, including payments of principal and interest made hereunder and
pursuant to any other Loan Document, and all fees, expenses, indemnities and reimbursements, shall be made without set-off, recoupment or counterclaim, in lawful money of the United States and in immediately
available funds. 
 2.4. Expenses. Borrower shall pay to Lender, all Lender Expenses incurred through and after the Tranche A
Closing Date, promptly after receipt of a written demand therefore setting forth in reasonable detail such Lender Expenses. 
 2.5.
Requirements of Law; Increased Costs; Mitigation. In the event that any applicable Change in Law: 
 (a) Does or shall subject Lender
to any Indemnified Tax of any kind whatsoever with respect to this Agreement or any Term Loan made hereunder (except Excluded Taxes, Connection Income Taxes and Other Connection Taxes); 

(b) Does or shall impose, modify or hold applicable any reserve, capital requirement, special deposit, compulsory loan or similar requirements
against assets held by, or deposits or other liabilities in or for the account of, advances or loans by, or other credit extended by, or any other acquisition of funds by, Lender; or 

(c) Does or shall impose on Lender any other condition (other than Taxes); and the result of any of the foregoing is to increase the cost to
Lender (as determined by Lender in good faith using calculation methods customary in the industry) of making, renewing or maintaining any Term Loan or to reduce any amount receivable in respect thereof or to reduce the rate of return on the capital
of Lender or any Person controlling Lender, 
 then, in any such case, Lender shall promptly notify Borrower in writing of the event by
reason of which it has incurred additional costs or has reduced amounts receivable or rate of return, and submit to Borrower a certificate as to such additional costs or has reduced amounts receivable or rate of return containing the calculation
thereof in reasonable detail, which shall be conclusive in the absence of manifest error. Lender shall first, prior to Borrower being required to take any action under this Section 2.5, take commercially reasonable actions
to mitigate the additional costs or reduced amounts receivable or rate of return, including assigning all of its rights and delegating and transferring all of its obligations hereunder to an existing Affiliate of Lender that would not be subject to
such, or would be subject to less, additional costs or reduced amounts receivable or rate of return, if any. Borrower shall promptly pay to Lender, subject to the terms of this Section 2.5, any undisputed additional amounts
necessary to compensate Lender for such additional cost or reduced amounts receivable or rate of return as reasonably determined by Lender with respect to this Agreement or the Term Loans made hereunder. 

The provisions hereof shall survive the termination of this Agreement and payment of the outstanding Term Loans and all other Obligations. Failure or delay on
the part of Lender to demand compensation for any increased costs or reduction in amounts received or receivable or reduction in return on capital under this Section 2.5 shall not constitute a waiver of Lender’s right
to demand such compensation; provided that Borrower shall not be under any obligation to compensate Lender under this Section 2.5 with respect to increased costs or reductions with respect to any period prior to the
date that is 180 days prior to the date of the delivery of the notice required pursuant to the foregoing provisions of this paragraph; provided, further, that the foregoing limitation shall not apply to any 

increased costs or reductions arising out of the retroactive application of any Change in Law within such 180-day
period. 

  
 3 

 2.6. Taxes; Withholding, etc. 

(a) All sums payable by any Credit Party hereunder and under the other Loan Documents shall (except to the extent required by Requirements of
Law) be paid free and clear of, and without any deduction or withholding on account of, any Tax imposed, levied, collected, withheld or assessed by any Governmental Authority. In addition, Borrower agrees to pay, and shall indemnify and hold Lender
harmless from, Other Taxes, and within thirty (30) days after the date of paying such sum, Borrower shall furnish to Lender the original or a certified copy of a receipt evidencing payment thereof. 

(b) If any Credit Party or any other Person is required by Requirements of Law to make any deduction or withholding on account of any Tax from
any sum paid or payable by any Credit Party to Lender under any of the Loan Documents: (i) Borrower shall notify Lender in writing of any such requirement or any change in any such requirement promptly after Borrower becomes aware of it;
(ii) Borrower shall make any such withholding or deduction; (iii) Borrower shall pay any such Tax before the date on which penalties attach thereto, such payment to be made (if the liability to pay is imposed on any Credit Party) for its
own account or (if that liability is imposed on Lender, as the case may be) on behalf of and in the name of Lender in accordance with applicable Law; (iv) if the Tax is an Indemnified Tax, the sum payable by such Credit Party in respect of
which the relevant deduction, withholding or payment of Indemnified Tax is required shall be increased to the extent necessary to ensure that, after the making of that deduction, withholding or payment (including any deductions for Indemnified Taxes
applicable to additional sums payable under this Section 2.6(b)), Lender receives on the due date a net sum equal to what it would have received had no such deduction, withholding or payment of Indemnified Tax been required
or made; and (v) within thirty (30) days after paying any sum from which it is required by Requirements of Law to make any deduction or withholding, and within thirty (30) days after the due date of payment of any Tax which it is
required by clause (ii) or (iii) above to pay, Borrower shall deliver to Lender evidence reasonably satisfactory to Lender of such deduction, withholding or payment and of the remittance thereof to the relevant taxing or other
Governmental Authority. Borrower shall indemnify Lender for the full amount of any Indemnified Taxes (including Indemnified Taxes imposed or asserted on or attributable to amounts payable under this Section 2.6(b)) paid by
Lender and any liability (including penalties, interest and reasonable expenses) arising therefrom or with respect thereto whether or not such Indemnified Taxes were correctly or legally imposed or asserted by the relevant Governmental Authority.
Any indemnification payment pursuant to this Section 2.6 shall be made within thirty (30) days from written demand therefor. 

(c) If Lender is organized under the laws of the United States of America or any state thereof, Lender shall deliver to Borrower two
(2) copies of Internal Revenue Service Form W-9. If Lender is not a “United States person” (as such term is defined in Section 7701(a)(30) of the IRC) for U.S. federal income Tax purposes,
Lender shall deliver, and shall cause each applicable assignee thereof to deliver, to Borrower, on or prior to, the Tranche A Closing Date and, the date on which a Lender Transfer occurs, as applicable, and at such other times as may be necessary in
the determination of Borrower (in the reasonable exercise of its discretion), two (2) properly completed and duly executed original copies of Internal Revenue Service Form W-8BEN, W-8BEN-E, W-8ECI or W-8IMY (along with Form W-9, W-8BEN-E or W-8BEN for each beneficial owner that will receive, directly or indirectly, a payment of principal, interest, fees or other
amounts payable under any of the Loan Documents), or any successor forms, and such other documentation required under the IRC and reasonably requested by Borrower to establish the appropriate amount of any deduction or withholding of United States
federal Tax, if any, with respect to any payments to such Lender of principal, interest, fees or other amounts payable under any of the Loan Documents, including any such additional documentation reasonably requested by Borrower as may be necessary
for Borrower to comply with its obligations under FATCA. If Lender is required to deliver any forms, statements, certificates or other evidence with respect to United States federal Tax or backup withholding matters pursuant to this
Section 2.6(c), Lender hereby agrees, from time to time after the initial delivery by Lender of such forms, certificates or other evidence, whenever a lapse in time, change in circumstances or law, or additional guidance by
a Governmental Authority renders such forms, certificates or other evidence obsolete or inaccurate in any material respect, to promptly deliver to Borrowers two (2) new original copies of Internal Revenue Service Form W-8BEN, W-8BEN-E W-8ECI, W-9 or W-8IMY (along with Internal Revenue Service Forms W-9, W-8BEN-E or W-8BEN for each beneficial owner for whom it expects to receive a payment), or any successor form, as 

  
 4 

 
the case may be, properly completed and duly executed by Lender, and such other documentation required under the IRC and reasonably requested by Borrower to confirm or establish the extent to
which Lender is or is not subject to deduction, backup withholding or withholding of United States federal Tax with respect to payments to Lender under the Loan Documents, or notify Borrowers of its inability under Requirements of Law to deliver any
such forms, certificates or other evidence. If Lender is claiming an exemption from United States withholding Tax pursuant to the “portfolio interest exemption”, it shall provide Borrower with the applicable Internal Revenue Service Form W-8 and a certificate as reasonably requested by Borrower certifying Lender’s entitlement thereto. Borrower shall not be required to pay any additional amount to Lender under
Section 2.6(b)(iii) if Lender shall have failed (1) to timely deliver to Borrower the forms, certificates or other evidence referred to in this Section 2.6(c) (each of which shall be complete,
accurate and duly executed), or (2) to notify Borrowers of its inability to deliver any such forms, certificates or other evidence, as the case may be; provided that, if Lender shall have satisfied the requirements of the first sentence
of this Section 2.6(c) on the Tranche A Closing Date (or on the date such Lender initially acquires an interest in a Term Loan), nothing in this last sentence of this Section 2.6(c) shall relieve
Borrower of its obligations to pay any additional amounts pursuant to this Section 2.6 in the event that, solely as a result of any change in any Requirements of Law or any change in the interpretation, administration or
application thereof by any applicable Governmental Authority, Lender is no longer legally entitled to deliver forms, certificates or other evidence at a subsequent date establishing the fact that Lender is not subject to withholding as described
herein and in the forms, certificates or other evidence initially provided by Lender. 
 (d) If any party hereto determines that it has
received a refund of any Taxes or a credit or offset for any Taxes as to which it has been indemnified pursuant to this Section 2.6 (including by the payment of additional amounts pursuant to this
Section 2.6), it shall pay to the indemnifying party an amount equal to such refund, credit or offset (but only to the extent of indemnity payments made, or additional amounts paid, under this
Section 2.6 with respect to the Taxes giving rise to such refund), net of all out-of-pocket expenses (including Taxes) of such indemnified
party and without interest (other than any interest paid by the relevant Governmental Authority with respect to such refund). Such indemnifying party, upon the request of such indemnified party, shall repay to such indemnified party the amount paid
over pursuant to this clause (d) in the event that such indemnified party is required to repay, credit or offset such refund to such Governmental Authority and the requirement to repay such refund to such Governmental Authority is not
due to the indemnified party’s failure to timely provide complete and accurate Internal Revenue Service forms and other documentation required pursuant to Section 2.6(c) or Section 2.8.
Notwithstanding anything to the contrary in this clause (d), in no event will the indemnified party be required to pay any amount to an indemnifying party pursuant to this clause (d) if the payment of such amount would place the
indemnified party in a less favorable net after-Tax position than the indemnified party would have been in if the indemnification payments or additional amounts giving rise to such refund had never been paid.
This clause (d) shall not be construed to require any indemnified party to make available its Tax returns (or any other information relating to its Taxes that it deems confidential) to the indemnifying party or any other Person. 

2.7. Additional Consideration. As additional consideration for the making of the Term Loans, Borrower shall pay to Lender the
following amounts (“Additional Consideration”) as follows: 
 (a) On the Tranche A Closing Date, Borrower shall pay to
Lender an amount equal to the product of the Tranche A Loan Amount and 0.015. 
 (b) In the event the Tranche B Loan is made on the Tranche B
Closing Date and in addition to the Additional Consideration payable pursuant to clause (a) above, on the Tranche B Closing Date, Borrower shall pay to Lender an amount equal to the product of the Tranche B Loan Amount and 0.015. 

(c) The obligations of Borrower under this Section 2.7 to pay Additional Consideration shall survive any and all
prepayments by Borrower. 
 2.8. Evidence of Debt; Register; Lender’s Books and Records; Term Loan Note. 

(a) Lender’s Evidence of Debt; Register. Notwithstanding anything herein to the contrary, Borrower hereby designates Lender to
serve as Borrower’s agent solely for purposes of maintaining at all times at Lender’s principal office a “book entry system” as described in IRC Treasury Regulation
Section 5f.103-1(c)(1)(ii) that identifies each beneficial owner that is entitled to a payment of principal and stated interest on the Term Loan 

  
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(the “Register”) so that the Term Loan is at all times in “registered form” as described in IRC Treasury Regulations
Section 5f.103-1(c). Lender is hereby authorized by Borrower to record in the manual or data processing records of Lender, the date and amount of each advance and the amount of the outstanding Obligations
and the date and amount of each repayment of principal and each payment of interest or otherwise on account of the Obligations. Absent manifest error, such Lender records shall be conclusive as to the outstanding principal amount of the total
outstanding Obligations, and the payment of interest, principal and other sums due hereunder; provided, however, that the failure of Lender to make any such record entry with respect to any payment shall not limit or otherwise affect
the obligations of Borrower under the Loan Documents. The Term Loan: (i) shall, pursuant to this clause (a), be also registered as to both principal and any stated interest with Borrower or its agent, and (ii) may be transferred by
Lender only by (1) surrender of the old instrument and either (x) the reissuance by Borrower of the old instrument to the new Lender or (y) the issuance by Borrower of a new instrument to the new Lender, or (2) confirmation with
Borrower that the right to the principal and stated interest on the Term Loan is maintained through the book entry system kept by Lender. Lender represents that any interest that may become due and owing under this Agreement qualifies for the
portfolio interest exception from withholding on interest payments pursuant to IRC Sections 871(h) and 881(c). 
 (b) Term Loan Notes.
Borrower shall execute and deliver to Lender (or, if applicable, to any Person who is an assignee of Lender pursuant to Section 11.1 hereof) to evidence the Term Loans (i) on the Tranche A Closing Date, the Tranche A
Note, and (ii) on the Tranche B Closing Date (if any), the Tranche B Note. 
 3. CONDITIONS OF LOANS 

3.1. Conditions Precedent to Tranche A Loan. Lender’s obligation to advance the Tranche A Loan is subject to the
satisfaction (or waiver in accordance with Section 11.5 hereof) of the following conditions: 
 (a) copies of the
Loan Documents (other than Loan Documents described in Schedule 5.16 of the Disclosure Letter) executed and delivered by each applicable Credit Party (or other party thereto), each schedule to such Loan Documents (including the Disclosure
Letter), such schedules to be in form and substance reasonably satisfactory to Lender, and the Disclosure Letter, if and to the extent any update thereto is necessary between the Effective Date and the Tranche A Closing Date; provided,
however, that in no event may the Disclosure Letter be updated in a manner that would reflect or evidence a Default or Event of Default (with or without such update); 

(b) (i) true, correct and complete copies of the Operating Documents of each of the Credit Parties and (ii) a Secretary’s
Certificate, dated the Tranche A Closing Date, certifying that the foregoing copies are true, correct and complete (such Secretary’s Certificate to be in form and substance reasonably satisfactory to Lender); 

(c) the Perfection Certificate for Borrower and its Subsidiaries, in form and substance reasonably satisfactory to Lender; 

(d) the organizational structure of Borrower and each of its Subsidiaries shall be as set forth on Schedule 3.1(d) of the Disclosure
Letter and (ii) the capital structure of Borrower and each of its Subsidiaries as of October 11, 2017 shall be as set forth on Schedule 3.1(d) of the Disclosure Letter; 

(e) a good standing certificate for each Credit Party (or equivalent certification if available in the case of a Credit Party that is
incorporated or organized under the laws of a jurisdiction other than the United States), certified by the Secretary of State (or the equivalent thereof) of the jurisdiction of incorporation or organization of such Credit Party (where such
certification is available) as of a date no earlier than thirty (30) days prior to the Tranche A Closing Date; 
 (f) a Secretary’s
Certificate with completed Borrowing Resolutions with respect to the Loan Documents and the Tranche A Loan for each Credit Party in form and substance reasonably satisfactory to Lender; 

  
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 (g) certified reports from an independent search service reasonably satisfactory to Lender,
dated as of a date no earlier than thirty (30) days prior to the Tranche A Closing Date, listing any judgment or tax lien filing or Code (or foreign equivalent) financing statement that, in each case, names any Credit Party as debtor in any
jurisdiction, the results of which shall be reasonably satisfactory to Lender, accompanied by written evidence (including any Code (or foreign equivalent) termination statements) that the Liens indicated in any such financing statements or other
documents either constitute Permitted Liens or have been or, in connection with the Tranche A Loan, will be terminated or released; 
 (h)
each Credit Party shall have obtained all Governmental Approvals and all consents of other Persons, in each case that are necessary or advisable in connection with the transactions contemplated by the Loan Documents and each of the foregoing shall
be in full force and effect and in form and substance reasonably satisfactory to Lender. All applicable waiting periods shall have expired without any action being taken or threatened in writing by any competent authority which would restrain,
prevent or otherwise impose adverse conditions on the transactions contemplated by the Loan Documents or the financing thereof and no action, request for stay, petition for review or rehearing, reconsideration, or appeal with respect to any of the
foregoing shall be pending, and the time for any applicable agency to take action to set aside its consent on its own motion shall have expired; 

(i) an opinion of Cooley LLP, in form and substance reasonably satisfactory to Lender; 

(j) evidence that the insurance policies required by Section 5.5 hereof are in full force and effect, together with appropriate evidence
showing loss payable or additional insured clauses or endorsements in favor of Lender (such evidence to be in form and substance reasonably satisfactory to Lender); 

(k) all documentation and other information required by bank regulatory authorities under applicable “know-your-customer” and
anti-money laundering rules and regulations, including the U.S.A. Patriot Act (Title III of Pub. L. 107-56 (signed into law October 26, 2001)) (the “Patriot Act”); 

(l) (i) a payoff letter in respect of the Indebtedness outstanding under the Existing Oxford Loan Agreement from Oxford Finance LLC, as
collateral agent thereunder, and evidence of repayment in full of such Indebtedness (including any and all expenses incurred in connection therewith) pursuant thereto prior to or concurrent with the funding of the Tranche A Loan on the Tranche A
Closing Date; and (ii) evidence that (A) the Liens securing any Indebtedness, guaranty or other obligations of Borrower or its Subsidiaries to Oxford Finance LLC under the Existing Oxford Loan Agreement or any lender party thereto have
been terminated and (B) the documents or filings evidencing the perfection of the foregoing Liens, including any financing statements or control agreements, have or will, concurrently with the funding of the Tranche A Loan on the Tranche A
Closing Date, be terminated; 
 (m) (i) statement of Net Sales of Borrower and its Subsidiaries for the quarterly period ended
September 30, 2017; (ii) audited consolidated financial statements for Borrower and its Subsidiaries for the period ended December 31, 2016; and (iii) for the interim period January 1, 2017 to the Tranche A Closing Date,
internally prepared, unaudited consolidated financial statements for Borrower and its Subsidiaries for each quarterly period completed prior to the Tranche A Closing Date and for each monthly period completed thirty (30) days prior to the
Tranche A Closing Date, each in form and substance satisfactory to Lender; 
 (n) evidence satisfactory to Lender in the form of a
certificate of a Responsible Officer of Borrower that, as of the Tranche A Closing Date, after giving effect to the transactions occurring on such date, including the incurrence of Indebtedness under the Term Loan Note that Borrower is Solvent, that
Borrower and its Subsidiaries that are Credit Parties, on a consolidated basis, are Solvent, and that Borrower and its Subsidiaries, on a consolidated basis, are Solvent; 

(o) payment of Lender Expenses as specified in Section 2.4 and payment of the Additional Consideration as specified
in Section 2.7 hereof; 
 (p) a certificate, dated the Tranche A Closing Date and signed by a Responsible Officer
of Borrower, confirming that there are no litigation, public or private, or administrative proceedings, governmental investigation or other legal or regulatory developments pending or, to the Knowledge of each Credit Party or any of its
Subsidiaries, threatened in writing, that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse Change except as set forth on Schedule 4.6 of the Disclosure Letter (such certificate to be in form and
substance reasonably satisfactory to Lender); and 

  
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 (q) a certificate, dated the Tranche A Closing Date and signed by a Responsible Officer of
Borrower, confirming satisfaction of the conditions precedent set forth in this Section 3.1 and Section 3.3 (such certificate to be in form and substance reasonably satisfactory to Lender). 

3.2. Conditions Precedent to Tranche B Loan. Lender’s obligation to advance the Tranche B Loan is subject to the
satisfaction (or waiver in accordance with Section 11.5 hereof) of the following conditions: 
 (a) a certificate,
dated the Tranche B Closing Date and signed by a Responsible Officer of Borrower, confirming that there are no litigation, public or private, or administrative proceedings, governmental investigation or other legal or regulatory developments pending
or, to the Knowledge of each Credit Party or any of its Subsidiaries, threatened in writing, that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse Change except as set forth on Schedule 4.6 of
the Disclosure Letter (such certificate to be in form and substance reasonably satisfactory to Lender); 
 (b) a certificate, dated the
Tranche B Closing Date and signed by a Responsible Officer of Borrower, confirming satisfaction of the conditions precedent set forth in this Section 3.2 and Section 3.3 (such certificate to be in
form and substance reasonably satisfactory to Lender); and 
 (c) an updated Disclosure Letter; provided that in no event may the
Disclosure Letter be updated in a manner that would reflect or evidence a Default or Event of Default (with or without such update). 

3.3. Additional Conditions Precedent to Term Loans. The obligation of Lender to make the Term Loans is subject to the
satisfaction (or waiver in accordance with Section 11.5 hereof) of the following additional conditions: 
 (a)
timely receipt of an executed Payment/Advance Form in the form of Exhibit A hereto; 
 (b) the representations and warranties made by
the Credit Parties in Section 4 of this Agreement and in the other Loan Documents are true and correct in all material respects, unless any such representation or warranty is stated to relate to a specific earlier date, in
which case such representation or warranty shall be true and correct in all material respects as of such earlier date (it being understood that any representation or warranty that is qualified as to “materiality,” “Material Adverse
Change,” or similar language shall be true and correct in all respects, in each case, on the Tranche A Closing Date, the Tranche B Closing Date or as of such earlier date, as applicable); and 

(c) there shall not have occurred (i) any Material Adverse Change or (ii) any Default or 

Event of Default. 
 3.4. Covenant to
Deliver. The Credit Parties agree to deliver to Lender each item required to be delivered to Lender under this Agreement as a condition precedent to the Credit Extensions; provided, however, that any such items set forth on
Schedule 5.16 of the Disclosure Letter shall be delivered to Lender within the time period prescribed therefor on such schedule. The Credit Parties expressly agree that any Credit Extensions made prior to the receipt by Lender of any such
item shall not constitute a waiver by Lender of the Credit Parties’ obligation to deliver such item, and the making of any Credit Extensions in the absence of a required item shall be in Lender’s sole discretion. 

3.5. Procedures for Borrowing. Subject to the prior satisfaction of all other applicable conditions to the making of the Term
Loans set forth in this Agreement, to obtain any Term Loan, Borrower shall deliver to Lender by electronic mail or facsimile a completed Payment/Advance Form in the form of Exhibit A hereto for the requested Term Loan executed by a
Responsible Officer of Borrower. In addition to the foregoing, if Borrower intends to obtain the Tranche B Loan, Borrower shall notify Lender (which notice shall be irrevocable on and after the date on which such notice is given and Borrower shall
be bound to make a borrowing in accordance therewith) by electronic mail or facsimile by no later than 12:00 noon on or before January 17, 2019, in which case Lender 

  
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shall make the Tranche B Loan available to Borrower not later than 2:00 p.m. on the date that is ten (10) Business Days following the date on which such notice is given by wire transfer of
same day funds in Dollars, to such account(s) in the United States as may be designated in writing to Lender by Borrower. 
 4.
REPRESENTATIONS AND WARRANTIES 
 In order to induce Lender to enter into this Agreement and to make the Credit Extensions to be
made on the Tranche A Closing Date and, if applicable, the Tranche B Closing Date, each Credit Party, jointly and severally, represents and warrants to Lender that the following statements are true and correct as of the Effective Date and on the
date on which each Term Loan is made (both with and without giving effect to such Term Loan): 
 4.1. Due Organization, Authorization;
Power and Authority. Each of Borrower and each of its Subsidiaries (a) is duly organized, validly existing and in good standing under the laws of its jurisdiction of organization as identified on Schedule 3.1(d) of the
Disclosure Letter or any Perfection Certificate updated in accordance with Section 4.5(a), (b) has all requisite power and authority to own, license and operate its properties, to carry on its business as now conducted and
as proposed to be conducted and (c) is qualified to do business and in good standing in every jurisdiction where its assets are located and wherever necessary to carry out its business and operations except where the failure to do so could not
reasonably be expected to have a Material Adverse Change. Each Credit Party has all requisite power and authority to enter into the Loan Documents to which it is a party and to carry out the transactions contemplated thereby. 

4.2. Equity Interests and Ownership. The Equity Interests of each Domestic Subsidiary (other than any Excluded Subsidiary and
any Domestic Subsidiary that is a CFC Holding Company), each Foreign Subsidiary directly owned by any Domestic Subsidiary and each CFC Holding Company directly owned by any Domestic Subsidiary, in each case, have been duly authorized and validly
issued and are fully paid and non-assessable (other than Equity Interests in limited liability companies and partnerships). The organizational structure, and capital structure as of October 11, 2017, of
Borrower and each of its Subsidiaries and the ownership interest of Borrower and each of its Subsidiaries in each of its respective Subsidiaries is as set forth on Schedule 3.1(d) of the Disclosure Letter. 

4.3. No Conflict; Government Consents. Except as set forth on Schedule 4.3 of the Disclosure Letter, the
execution, delivery and performance by each Credit Party of the Loan Documents to which it is a party have been duly authorized and do not (a) conflict with any of such Credit Party’s Operating Documents, (b) contravene, conflict
with, constitute a default under or violate any material Requirements of Law, (c) contravene, conflict or violate any applicable order, writ, judgment, injunction, decree, determination or award of any Governmental Authority by which such
Credit Party or any of its Subsidiaries or any of its or their respective properties or assets may be bound, (d) require any action by, filing, registration, or qualification with, or Governmental Approval from, any Governmental Authority
(except (i) such Governmental Approvals which have already been obtained and are in full force and effect, and (ii) for filings and recordings with respect to the Collateral to be made, or otherwise delivered to Lender for filing or
recordation on or after the Tranche A Closing Date), (e) constitute a material breach of or a material default or an event of default under, or result in or permit the termination or acceleration of, any Material Contract by which such Credit Party
is bound or (f) require any approval of stockholders, members or partners or any approval or consent of any Person except for such approvals or consents which will be obtained on or before the Tranche A Closing Date. Without limiting
Section 4.11 hereof, neither Borrower nor any of its Subsidiaries is in default under or breach of any Contract to which it is a party or by which it or its properties or assets are bound or affected in which the default
thereunder or breach thereof could reasonably be expected to have a Material Adverse Change. 
 4.4. Binding Obligation. Each Loan
Document has been duly executed and delivered by each Credit Party that is a party thereto and is the legally valid and binding obligation of such Credit Party, enforceable against such Credit Party in accordance with its respective terms,
except as may be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws relating to or limiting creditors’ rights generally or by equitable principles relating to enforceability. 

  
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 4.5. Collateral; Intellectual Property. In connection with this Agreement, the Credit
Parties have delivered to Lender a completed certificate signed by each Credit Party (the “Perfection Certificate”). Each Credit Party represents and warrants to Lender that: 

(a) (i) its exact legal name is that indicated on the Perfection Certificate and on the signature page hereof; (ii) it is an
organization of the type and is organized in the jurisdiction set forth in the Perfection Certificate; (iii) the Perfection Certificate accurately sets forth its organizational identification number or accurately states that it has none;
(iv) the Perfection Certificate accurately sets forth its place of business, or, if more than one, its chief executive office as well as its mailing address (if different than its chief executive office); (v) except as set forth in the
Perfection Certificate, it (and each of its predecessors) has not, in the past five (5) years, changed its jurisdiction of formation, organizational structure or type, or any organizational number assigned by its jurisdiction; and (vi) all
other information set forth on the Perfection Certificate pertaining to it is accurate and complete (it being understood and agreed that Borrower may from time to time update certain information in the Perfection Certificate after the Tranche A
Closing Date to the extent expressly permitted by one or more provisions in this Agreement and the other Loan Documents to reflect changes since the Tranche A Closing Date). If any Credit Party is not now a Registered Organization but later becomes
one, it shall promptly notify Lender of such occurrence and provide Lender with such Credit Party’s organizational identification number. Lender hereby agrees that the Perfection Certificate shall be deemed to be updated to reflect information
provided in any notice delivered by any Credit Party to Lender pursuant to Section 6.2; provided that any such update shall not relieve any Credit Party of any other Obligation under this Agreement, including its Obligations pursuant to
Section 5.7(b). 
 (b) (i) it has good title to, has rights in, and the power to transfer each item of Collateral upon which
it purports to grant a Lien hereunder or under any Collateral Document, free and clear of any and all Liens except Permitted Liens, (ii) it has no deposit accounts, securities accounts, commodity accounts or other investment accounts other than
(A) the deposit accounts, securities accounts, commodity accounts or other investment accounts described in the Perfection Certificate delivered to Lender in connection herewith, (B) the Excluded Accounts described in the Perfection
Certificate delivered to Lender in connection herewith (which may be updated on the Tranche B Closing Date) or (C) of which such Credit Party has given Lender written notice and taken (or is currently taking in good faith) such actions as are
necessary to give Lender a perfected security interest therein (and upon delivery of such notice and taking such action, the Perfection Certificate will be deemed to be updated with the information contained in such notice), (iii) Collateral is not
in the possession of any third party bailee (such as a warehouse) except as otherwise provided in the Perfection Certificate or as permitted pursuant to Section 6.2(c). None of the components of the Collateral shall be
maintained at locations other than as provided in the Perfection Certificate or as permitted pursuant to Section 6.2(c). 

(c) All Inventory of Borrower and each of its Subsidiaries held by any of them for sale or lease or to be furnished under Contract of service
in respect of any Product is in all material respects of good and marketable quality, free from material defects. 
 (d) A true, correct and
complete list, as of the Tranche A Closing Date, of all pending or issued Patents, Copyrights and Trademarks, which are included among Current Company IP (including the name/title, current owner, registration or application number, and registration
or application date and such other information as reasonably requested by Lender, if any) is set forth on Schedule 4.5(d) of the Disclosure Letter. Except as set forth on Schedule 4.5(d) of the Disclosure Letter, to the Knowledge of
each Credit Party or any of its Subsidiaries, (A) each item of Current Company IP which is owned by any Credit Party or any of its Subsidiaries is valid and subsisting and no such Intellectual Property has lapsed, expired, been cancelled or
become abandoned (other than as permitted by Section 6.1(j)) and (B) each item of Current Company IP which is licensed by any Credit Party or any of its Subsidiaries from another Person is valid and subsisting. To the
Knowledge of each Credit Party or any of its Subsidiaries, there are no published patents, patent applications, articles or prior art references that could reasonably be expected to materially adversely affect the validity or enforceability of any
of the Patents within the Product IP. Except as set forth on Schedule 4.5(d) of the Disclosure Letter, each Person who has or has had any rights in or to the Current Company IP or any trade secrets of any Credit Party or any of its
Subsidiaries, including each inventor named on the Patents within such Current Company IP filed by any Credit Party or any of its Subsidiaries, has executed a Contract assigning his, her or its entire right, title and interest in and to such Current
Company IP and such trade secrets, and the inventions, improvements, ideas, discoveries, writings, works of authorship, information and other intellectual property embodied, described or claimed therein, to the stated owner

  
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thereof and, to the Knowledge of each Credit Party or any of its Subsidiaries, no such Person has any contractual or other obligation that would preclude or conflict with such assignment or the
exploitation of Product or entitle such Person to ongoing payments (other than Consulting Royalties). Except for Permitted Licenses and as set forth on Schedule 4.5(d) of the Disclosure Letter, (i) no Person other than Borrower or a
Domestic Subsidiary of Borrower that is a Credit Party will have any right under the Current Company IP Agreements to Commercialize Products in the United States and (ii) no Person other than a Credit Party or a Subsidiary will have any right
under the Current Company IP Agreements to Commercialize Products in the Territory (other than the United States). 
 (e) Except for the
Permitted Licenses and except as described on Schedule 4.5(e) of the Disclosure Letter, (A) each Credit Party or any of its Subsidiaries, as the case may be, possesses sole, exclusive and valid title to the Current Company IP for which
it is listed as the owner on Schedule 4.5(d) of the Disclosure Letter; and (B) there are no Liens on or to any Current Company IP, other than Permitted Liens. 

(f) There are no maintenance, annuity or renewal fees that are currently overdue beyond their allotted grace period for any of the Current
Company IP which is owned by or exclusively licensed to any Credit Party or any of its Subsidiaries, as the case may be, nor have any applications or registrations therefor lapsed or become abandoned, been cancelled or expired (except as permitted
by Section 6.1(j)). To the Knowledge of each Credit Party or any of its Subsidiaries, there are no maintenance, annuity or renewal fees that are currently overdue beyond their allotted grace for any of the Current Company
IP which is not owned by or exclusively licensed to any Credit Party or any of its Subsidiaries, nor, to the Knowledge of each Credit Party or any of its Subsidiaries, have any applications or registrations therefor lapsed or become abandoned, been
cancelled or expired. 
 (g) Schedule 4.5(g) of the Disclosure Letter sets forth a true, correct and complete list of all Current
Company IP Agreements. There are no unpaid fees or royalties under any Current Company IP Agreement that have become due, or are expected to become overdue. Each Current Company IP Agreement is in full force and effect and, to the Knowledge of each
Credit Party or any of its Subsidiaries, is legal, valid, binding, and enforceable in accordance with its respective terms, except as may be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws relating to or limiting
creditors’ rights generally or by equitable principles relating to enforceability. No Credit Party or any of its Subsidiaries is in material breach of or default under any Current Company IP Agreement to which it is a party and, to the
Knowledge of each Credit Party or any of its Subsidiaries, no reasonable circumstances exist that would give rise to a claim of breach or right of rescission, termination, non-renewal, revision or amendment of
any of the Current Company IP Agreements, including the execution, delivery and performance of this Agreement and the other Loan Documents. 

(h) Except for Consulting Royalties and as otherwise set forth on Schedule 4.5(h) of the Disclosure Letter, no payments by any Credit
Party or any of its Subsidiaries are due to any other Person in respect of the Current Company IP, other than pursuant to the Current Company IP Agreements and those fees payable to patent offices in connection with the prosecution and maintenance
of the Current Company IP and associated attorney fees. There is no Intellectual Property licensed in to any Credit Party or any of its Subsidiaries from any Person with respect to which such Person currently receives or may receive in the future
any Consulting Royalties. 
 (i) No Credit Party or any of its Subsidiaries has intentionally, willfully or knowingly undertaken or omitted
to undertake any acts, and, to the Knowledge of each Credit Party or any of its Subsidiaries, no reasonable circumstance or grounds exist, that would invalidate, reduce or eliminate, in whole or in part, (i) the enforceability or scope of any
Current Company IP or (ii) in the case of Current Company IP owned or exclusively licensed by any Credit Party or any of its Subsidiaries, as the case may be, other than with respect to Permitted Licenses and, except as set forth on Schedule
4.5(i) of the Disclosure Letter, such Credit Party’s or such Subsidiary’s entitlement to exclusively own or license and exploit the Current Company IP. 

(j) Except as set forth on Schedule 4.6 of the Disclosure Letter or as notified to Lender in writing pursuant to
Section 5.2(d), there is no pending, decided or settled opposition, interference proceeding, reissue proceeding, reexamination proceeding, inter-partes review proceeding, post-grant review proceeding, cancellation
proceeding, injunction, lawsuit, hearing, investigation, complaint, arbitration, mediation, demand, International Trade Commission investigation, decree, or any other dispute, disagreement, or claim, in each case, alleged in writing to Borrower or
any of its Subsidiaries (collectively referred to hereinafter as “Specified Disputes”), nor, to the Knowledge of each Credit Party or any of its Subsidiaries, has any Specified Dispute been 

  
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threatened in writing, in each case, challenging the legality, validity, enforceability or ownership of any Current Company IP. Except as noted on Schedule 4.5(j) of the Disclosure Letter,
to the Knowledge of each Credit Party or any of its Subsidiaries, there is no patent or patent application of any third party that interferes with a Patent within the Current Company IP. 

(k) Except as noted on Schedule 4.5(k) of the Disclosure Letter and other than Restricted Licenses entered into in compliance with
Section 5.7(b), no Credit Party is a party to, nor is it bound by, any Restricted License. 
 (l) Except as noted
on Schedule 4.5(l) of the Disclosure Letter, the packaging for any and all Products Manufactured, used or Commercialized under the Patents within the Current Company IP have been marked with the proper patent notice. 

(m) Except as noted on Schedule 4.5(m) of the Disclosure Letter, in each case where a Patent within the Current Company IP is held by
any Credit Party or its Subsidiaries by assignment, the assignment has been duly recorded with the U.S. Patent and Trademark Office and all similar offices and agencies anywhere in the world in which foreign counterparts are registered or issued.

 (n) There are no pending or, to the Knowledge of each Credit Party or any of its Subsidiaries, threatened (in writing) claims against any
Credit Party or any of its Subsidiaries alleging (i) that any of the operation of the business of or any activity by any Credit Party or any of its Subsidiaries, or the Manufacture, Commercialization, or use of any Product infringes or violates
(or in the past infringed or violated) the rights of third parties in or to any Intellectual Property (“Third Party IP”) or constitutes a misappropriation of (or in the past constituted a misappropriation of) any subject matter of
any Third Party IP or (ii) that any of the Current Company IP is invalid or unenforceable. 
 (o) Neither the operation of the business
of, nor any activity by, any Credit Party or any of its Subsidiaries, nor the Manufacture, use or Commercialization of any Product, infringes or violates (or in the past infringed or violated) any Third Party IP, other than any patent within the
Third Party IP, or constitutes a misappropriation of (or in the past constituted a misappropriation of) any subject matter of any Third Party IP, and to the Knowledge of each Credit Party or any of their Subsidiaries, neither the operation of the
business of, nor any activity, by any Credit Party or any of its Subsidiaries, nor the Manufacture, use or Commercialization of any Product, infringes or violates (or in the past infringed or violated) any patent within the Third Party IP. 

(p) Except for customary indemnities provided to customers in the ordinary course of business in connection with the sale of the Product and as
otherwise noted on Schedule 4.5(p) of the Disclosure Letter, no Credit Party or any of its Subsidiaries has entered into any Contract to indemnify any other Person against any claims of infringement, violation or misappropriation of any
Intellectual Property. 
 (q) Except as noted on Schedule 4.5(q) of the Disclosure Letter, there are no settlements, covenants not to
sue, consents, judgments, or orders or similar obligations that (i) restrict the rights of any Credit Party or any of its Subsidiaries to use any Intellectual Property, (ii) restrict the business of any Credit Party or any of its
Subsidiaries, in order to accommodate a third party’s Intellectual Property or (iii) permit third parties to use any Company IP. 

(r) To the Knowledge of each Credit Party or any of their Subsidiaries, each Credit Party and each of its Subsidiaries has obtained and
possesses valid licenses to use all of the software programs present on the computers and other software-enabled electronic devices that it owns or leases or that it has otherwise provided to its employees for their use in connection with the
business of such Credit Party and its Subsidiaries. 
 (s) To the Knowledge of each Credit Party or any of its Subsidiaries, (i) there
is no, nor has there been any, infringement or violation by any Person of any of the Product IP or the rights therein or thereto of any Credit Party or any of its Subsidiaries and (ii) there is no, nor has there been any, misappropriation by
any Person of any of the Product IP or the subject matter thereof. 

  
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 (t) Each Credit Party and each of its Subsidiaries have taken all commercially reasonable
security measures to protect the confidentiality and value of all trade secrets owned by such Credit Party or any of its Subsidiaries or used or held for use by such Credit Party or any of its Subsidiaries in the business of such Credit Party and
its Subsidiaries, including requiring each employee and consultant of such Credit Party or any of its Subsidiaries and any other Person with access to such trade secrets to execute a binding confidentiality or nondisclosure Contract, copies or forms
of which have been provided to Lender and, to the Knowledge of each Credit Party or any of its Subsidiaries, there has not been any material breach by any party to such confidentiality Contracts. 

(u) Each Product performs in accordance with its documented specifications and as warranted to the customers thereof, except to the extent any
such failure to so perform could not reasonably be expected to have a Material Adverse Change. 
 (v) The Credit Parties and their
Subsidiaries (i) collect or use personally identifiable information from any third parties (including patients) and (ii) in connection with any collection or use of personally identifiable information, to the Knowledge of each Credit Party
or any of its Subsidiaries, each Credit Party or any of its Subsidiaries has complied with all applicable statutes and regulations in all relevant jurisdictions and its publicly available privacy policy (if any) relating to the collection, storage,
use and onward transfer of all personally identifiable information collected by such Credit Party or Subsidiary or by third parties having authorized access to databases or other records of such Credit Party or Subsidiary. 

(w) Each Credit Party and each of its Subsidiaries have reasonable policies, procedures and security measures in place to protect information
relating to its customers (“Customer Data”) under its and its service providers’ possession or control from unauthorized access; and, to the Knowledge of each Credit Party or any of its Subsidiaries, each Credit Party, each of
its Subsidiaries, and each of its service providers’ hardware, software, encryption, systems, policies and procedures are sufficient to protect the security and confidentiality of all Customer Data that complies in all material respects with
Requirements of Law. To the Knowledge of each Credit Party or any of its Subsidiaries, no Credit Party, any of its Subsidiaries, or any of its service providers has suffered any breach in security that has permitted any unauthorized access to
Customer Data. 
 4.6. Adverse Proceedings, etc. Except as set forth on Schedule 4.6 of the Disclosure Letter or
as notified to Lender in writing pursuant to Section 5.2(d), there are no Adverse Proceedings, individually or in the aggregate, that could reasonably be expected to result in a Material Adverse Change. Neither
Borrower nor any of its Subsidiaries (a) is in violation of any Requirements of Law (including Environmental Laws) that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse Change, or (b) is
subject to or in default with respect to any final judgments, orders, writs, injunctions, decrees, rules or regulations of any court or any federal, state, municipal or other governmental department, commission, board, bureau, agency or
instrumentality, domestic or foreign, that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse Change. 

4.7. Financial Statements; Material Contracts; No Material Adverse Change; Books and Records. 

(a) All consolidated financial statements of Borrower and each of its Subsidiaries delivered to Lender pursuant to
Section 3.1(m) were prepared in conformity with Applicable Accounting Standards applied on a consistent basis throughout the periods covered thereby, except as otherwise disclosed therein and, in the case of unaudited,
interim financial statements, subject to normal year-end audit adjustments and the exclusion of certain footnotes, and fairly present in all material respects the consolidated financial condition of Borrower
and its Subsidiaries and their consolidated results of operations as of the dates indicated and the results of their operations and the changes in their cash flows for the periods specified. Since the date of the most recent financial statements
delivered to Lender pursuant to Section 3.1(m), there has not been any material deterioration in the consolidated financial condition of Borrower and its Subsidiaries. Neither Borrower nor any of its Subsidiaries has any
contingent liability or liability for Taxes, long-term lease (other than long-term leases entered into in the ordinary course of business) or unusual forward or long-term commitment that is not reflected in the consolidated financial statements or
the notes thereto delivered to Lender pursuant to Section 3.1(m) and which in any such case is material in relation to the business, operations, properties, assets, or condition (financial or otherwise) of Borrower and its

  
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Subsidiaries taken as a whole. Since the date of the most recent audited financial statements delivered to Lender pursuant to Section 3.1(m), no change in the business,
assets, liabilities, financial condition or results of operations of Borrower or any of its Subsidiaries has occurred, and no event has occurred or failed to occur, that has had or could reasonably be expected to have, either alone or in conjunction
with all other such changes, events and failures, a Material Adverse Change; 
 (b) Since December 31, 2016, (i) neither Borrower nor
any of its Subsidiaries has entered into any Material Contract or has incurred any liability or obligation, direct or contingent, that, individually or in the aggregate, is material to Borrower and its Subsidiaries, taken as a whole, except as
otherwise disclosed in Schedule 4.7(b) of the Disclosure Letter or in financial statements delivered to Lender pursuant to Section 3.1(m)(i), Section 

3.1(m)(ii) or Section 5.2 and (ii) neither Borrower nor any of its Subsidiaries has sustained any loss or
interference with its business that, individually or in the aggregate, is material to Borrower and its Subsidiaries, taken as a whole, and that is either from fire, explosion, flood or other calamity, whether or not covered by insurance, or from any
labor disturbance or dispute or any action, order or decree of any arbitrator or Governmental Authority, except as otherwise disclosed in the financial statements delivered to Lender pursuant to Section 3.1(m)(i),
Section 3.1(m)(ii) or Section 5.2; and 
 (c) The Books of Borrower and each of its
Subsidiaries contain full, true and correct entries in all material respects of all material dealings and transactions in relation to its business and activities in conformity with Applicable Accounting Standards and all Requirements of Law. 

4.8. Solvency. Borrower is Solvent, Borrower and its Subsidiaries that are Credit Parties, on a consolidated basis, are Solvent
and Borrower and its Subsidiaries, on a consolidated basis, are Solvent. Without limiting the generality of the foregoing, there has been no proposal made or resolution adopted by any competent corporate body for the dissolution or liquidation of
any Credit Party, nor do any circumstances exist which may result in the dissolution or liquidation of any Credit Party (other than in respect of a dissolution or liquidation permitted under Section 6.3). No proposal has
been made nor any resolution been adopted by any competent corporate body of any Credit Party for the statutory merger of such Credit Party with any other Person (including for any merger permitted by Section 6.3). None of
the Credit Parties has (i) made a general assignment for the benefit of creditors, (ii) filed any voluntary petition in bankruptcy or suffered the filing of an involuntary petition by any creditor, (iii) suffered the appointment of a
receiver to take possession of all or any portion of its assets, (iv) suffered the attachment or judicial seizure of all or any portion of its assets, (v) admitted in writing its inability to pay its debts as they come due, nor
(vi) made an offer of settlement, extension or composition to its creditors generally. 
 4.9. Payment of Taxes. All United
States federal, foreign and material state, local and other Tax returns and reports (or extensions thereof) of each Credit Party and each of its Subsidiaries required to be filed by any of them have been timely filed, and all material Taxes
which are due and payable by any Credit Party or any of its Subsidiaries and all material assessments, fees and other governmental charges upon any Credit Party or any of its Subsidiaries and upon their respective properties, assets, income,
businesses and franchises which are due and payable have been paid when due and payable except where the validity or amount thereof is being contested in good faith by appropriate proceedings; provided that (a) the applicable Credit
Party has set aside on its books adequate reserves therefor in conformity with Applicable Accounting Standards and (b) the failure to pay such Taxes, individually or in the aggregate, could not reasonably be expected to result in a Material
Adverse Change. No Credit Party knows of any proposed Tax deficiency or assessment against it or any of its Subsidiaries which is not being actively contested by it or such Subsidiary in good faith and by appropriate proceedings; provided
that such reserves or other appropriate provisions, if any, as shall be required in conformity with Applicable Accounting Standards shall have been made or provided therefor. Neither any Credit Party nor any of its Subsidiaries have executed or
filed with the Internal Revenue Service or any other Governmental Authority any Contract or other document extending, or having the effect of extending, the period for assessment or collection of any Taxes nor has there been any request in writing
for such extension. No claim has been made by a Tax authority in a jurisdiction where any Credit Party does not pay Taxes or file Tax returns that such Credit Party is subject to Taxes assessed by such jurisdiction. No Credit Party is or will be
required to include any material item of income in, or exclude any material item of deduction from, taxable income for any taxable period (or portion thereof) as a result of any intercompany transaction. 

  
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 4.10. Environmental Matters. Neither Borrower nor any of its Subsidiaries nor any of
its or their respective Facilities or operations are subject to any outstanding written order, consent decree or settlement Contract with any Person relating to any Environmental Law, any Environmental Claim, or any Hazardous Materials
Activity that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse Change. Neither Borrower nor any of its Subsidiaries has received any letter or request for information under Section 104 of the
Comprehensive Environmental Response, Compensation, and Liability Act (42 U.S.C. § 9604) or any comparable state law. There are no, and to the Knowledge of each Credit Party or any of its Subsidiaries there have been no, conditions,
occurrences, or Hazardous Materials Activities which could reasonably be expected to form the basis of an Environmental Claim against Borrower or any of its Subsidiaries that, individually or in the aggregate, could reasonably be expected to result
in a Material Adverse Change. To the Knowledge of each Credit Party or any of its Subsidiaries, no predecessor of Borrower or any of its Subsidiaries has filed any notice under any Environmental Law indicating past or present treatment of Hazardous
Materials at any Facility, and neither Borrower’s nor any of its Subsidiaries’ operations involves the generation, transportation, treatment, storage or disposal of hazardous waste, as defined under 40 C.F.R. Parts 260 270 or any state
equivalent. Compliance by Borrower and its Subsidiaries with all requirements pursuant to or under Environmental Laws which are applicable to or binding upon Borrower or any of its Subsidiaries or any of its or their respective properties or assets
or to which Borrower or any of its Subsidiaries or any of its or their respective properties or assets is subject could not, individually or in the aggregate, be reasonably expected to result in a Material Adverse Change. No event or condition has
occurred or is occurring with respect to any Credit Party relating to any Environmental Law, any Release of Hazardous Materials, or any Hazardous Materials Activity which, individually or in the aggregate, has resulted in, or could reasonably be
expected to result in, a Material Adverse Change. 
 4.11. Material Contracts. Schedule 4.11 of the Disclosure
Letter contains a true, correct and complete list of all of the Material Contracts in effect on the Tranche A Closing Date. After giving effect to the consummation of the transactions contemplated by this Agreement and the other Loan
Documents, except as described on Schedule 4.11 of the Disclosure Letter, each Material Contract is a valid and binding obligation of the applicable Credit Party or its Subsidiaries and is in full force and effect, and neither the applicable
Credit Party or Subsidiary nor, to the Knowledge of each Credit Party or any of its Subsidiaries, each other party thereto, is in material breach thereof or material default thereunder. Except as described on Schedule 4.11 of the Disclosure
Letter with respect to the Existing Oxford Loan Agreement, no Credit Party or any of its Subsidiaries has received any written notice from any other party thereto asserting or, to the Knowledge of each Credit Party or any of its Subsidiaries
threatening to assert, the cancellation, termination or invalidation of any Material Contract. Borrower has previously made available to Lender true, correct and complete copies of each Material Contract. 

4.12. Regulatory Compliance. No Credit Party is an “investment company” or a company “controlled” by an
“investment company” under the Investment Company Act of 1940, as amended. No Credit Party is engaged as one of its important activities in extending credit for margin stock (under Regulations X, T and U of the Federal Reserve Board). Each
Credit Party has complied in all material respects with the Federal Fair Labor Standards Act. Each of Borrower and its Subsidiaries and each of their respective ERISA Affiliates is in compliance with the applicable provisions of ERISA and the IRC
and the regulations and published interpretations thereunder, except where such failure to comply could not reasonably be expected to result in any material liability of Borrower or its Subsidiaries or their respective ERISA Affiliates. No ERISA
Event has occurred or is reasonably expected to occur that, when taken together with any other ERISA Events, could reasonably be expected to result in material liability of Borrower or its Subsidiaries or any of their respective ERISA Affiliates or
the imposition of a Lien on any of the properties or assets of Borrower or any of its Subsidiaries. The present value of all accumulated benefit obligations of all underfunded Plans (based on the assumptions used for purposes of Statement of
Financial Accounting Standards No. 87) did not, as of the date of the most recent financial statements reflecting such amounts, exceed by more than $250,000 the fair market value of the property of all such underfunded Plans. Neither Borrower
nor any of its Subsidiaries nor any of their respective ERISA Affiliates has any Multiemployer Plan or any obligation to contribute to a Multiemployer Plan. 

4.13. Margin Stock. No Credit Party is engaged, nor will it engage, principally or as one of its important activities, in the
business of extending credit for the purpose of “purchasing” or “carrying” any “margin stock” as such terms are defined in Regulation U of the Federal Reserve Board as now and from time to time hereafter in effect (such
securities being referred to herein as “Margin Stock”). None of the proceeds of the Credit Extensions or other extensions of credit under this Agreement will be used, directly or indirectly, for the purpose of 

  
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 purchasing or carrying any Margin Stock, for the purpose of reducing or retiring any Indebtedness that was
originally incurred to purchase or carry any Margin Stock or for any other purpose that might cause any of the Term Loans or other extensions of credit under this Agreement to be considered a “purpose credit” within the meaning of
Regulations T, U or X of the Federal Reserve Board. No Credit Party or any of its Subsidiaries will take or permit to be taken any action that might cause any Loan Document to violate any regulation of the Federal Reserve Board. 

4.14. Subsidiaries; Investments; Affiliate Transactions. Neither Borrower nor any of its Subsidiaries owns any stock,
partnership interest or other equity securities except for Permitted Investments. Set forth on Schedule 4.14 of the Disclosure Letter is a true, correct and complete list of all transactions between any Credit Party or any of its
Subsidiaries, on the one hand, and any Affiliate of any Credit Party or any owner of ten percent (10%) or more of the Equity Interests of any Credit Party or any of its Subsidiaries or any Affiliate of any such Person, on the other hand (other than
(a) Transfers of Inventory in the ordinary course of business between or among any Credit Party or any of its Subsidiaries and (b) equity offering documents, investor rights agreements, registration rights agreements, organizational
documents and similar Contracts entered into in connection with any equity financing). Except as set forth on Schedule 4.14 of the Disclosure Letter, Borrower does not own or control, directly or indirectly, any interest in any Person other
than a Subsidiary and is not a participant in any joint venture, partnership or similar arrangement. 
 4.15. Employee Matters.
Neither Borrower nor any of its Subsidiaries is engaged in any unfair labor practice that could reasonably be expected to result in a Material Adverse Change. There is (a) no unfair labor practice complaint pending against Borrower or
any of its Subsidiaries, or to the Knowledge of each Credit Party or any of its Subsidiaries, threatened in writing against any of them before the National Labor Relations Board and no grievance or arbitration proceeding arising out of or under any
collective bargaining agreement that is so pending against Borrower or any of its Subsidiaries or to the Knowledge of each Credit Party or any of its Subsidiaries, threatened in writing against any of them, (b) no strike or work stoppage in
existence or, to the Knowledge of each Credit Party or any of its Subsidiaries, threatened in writing involving Borrower or any of its Subsidiaries, and (c) to the Knowledge of each Credit Party or any of its Subsidiaries, no union
representation question existing with respect to the employees of Borrower or any of its Subsidiaries and, to the Knowledge of each Credit Party or any of its Subsidiaries, no union organization activity that is taking place that, individually or
together with any other matter specified in clause (a) or (b) above or this clause (c), could reasonably be expected to result in a Material Adverse Change. 

4.16. Use of Proceeds. Borrower shall use the proceeds of the Credit Extensions solely to repay in full the Indebtedness
outstanding under the Existing Oxford Loan Agreement and any and all associated costs and expenses and to fund its general business requirements and not for any other purposes, including personal, family, household or agricultural purposes. 

4.17. Full Disclosure. No representation or warranty of any Credit Party contained in any Loan Document or in any other
documents, certificates or written statements (excluding any projections and pro forma financial information, any presentations made by Borrower and any third party agreements of Borrower) furnished to Lender by or on behalf of any Credit Party for
use in connection with the transactions contemplated hereby contains any untrue statement of a material fact or omits to state a material fact (to the Knowledge of each Credit Party or any of its Subsidiaries, in the case of any document not
furnished by it) necessary in order to make the statements contained herein or therein, not misleading in light of the circumstances in which the same were made. Any projections and pro forma financial information contained in such materials
represent the best good faith estimates of the Credit Party furnishing such materials and are based on assumptions believed by such Credit Party to be fair and reasonable at the time made. Lender acknowledges and agrees that projections as to future
events are not to be viewed as facts and that the actual results during the period or periods covered by such projections may differ from the projected results. 

4.18. FCPA; Patriot Act; OFAC. 

(a) None of Borrower, its Subsidiaries or, to the Knowledge of each Credit Party or any of its Subsidiaries, any director, officer, agent or
employee or Borrower or any Subsidiary of Borrower has (i) used any corporate funds of Borrower or any of its Subsidiaries for any unlawful contribution, gift, entertainment or other unlawful expense relating to political activity,
(ii) made any direct or indirect unlawful payment to any foreign or 

  
 16 

 domestic government official or employee from corporate funds of Borrower or any of its Subsidiaries,
(iii) violated or is in violation of any provision of the Foreign Corrupt Practices Act of 1977, as amended (the “FCPA”) or (iv) made any bribe, rebate, payoff, influence payment, kickback or other unlawful payment, and no
part of the proceeds of any Credit Extension will be used, directly or indirectly, for any payments to any governmental official or employee, political party, official of a political party, candidate for political office or anyone else acting in an
official capacity, in order to obtain, retain or direct business or obtain any improper advantage in violation of the FCPA; 
 (b) (i)
The operations of Borrower and its Subsidiaries are and have been conducted at all times in compliance with applicable financial recordkeeping and reporting requirements of the Currency and Foreign Transactions Reporting Act of 1970, as amended, the
Bank Secrecy Act of 1970, as amended by Title III of the Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism (USA PATRIOT) Act of 2001 and the money laundering laws, rules and regulations of
each jurisdiction (foreign or domestic) in which Borrower or any of its Subsidiaries is subject to such jurisdiction’s Requirements of Law (collectively, the “Money Laundering Laws”) and (ii) no action, suit or proceeding
by or before any Governmental Authority or any arbitrator involving Borrower or any of its Subsidiaries with respect to the Money Laundering Laws is pending or threatened in writing; and 

(c) None of Borrower, its Subsidiaries or, to the Knowledge of each Credit Party or any of its Subsidiaries, any director, officer, agent or
employee of Borrower or any Subsidiary of Borrower is currently subject to any U.S. sanctions administered by the Office of Foreign Assets Control of the U.S. Department of the Treasury (“OFAC”) or imposed by the Trading with the
Enemy Act, 50 U.S.C. App. 1 et seq. Borrower will not, directly or, to the Knowledge of each Credit Party or any of its Subsidiaries, indirectly through an agent, use the proceeds of the Credit Extension, or lend, contribute or otherwise make
available such proceeds to any Subsidiary, joint venture partner or other Person, for the purpose of financing the activities of any Person currently subject to any U.S. sanctions administered by OFAC. 

4.19. Insurance Contracts. Schedule 4.19 of the Disclosure Letter contains a true, correct and complete
list of all insurance companies with which any Credit Party or any of its Subsidiaries has agreed to contracted pricing for the Products. 

4.20. Health Care Matters. 

(a) Compliance with Health Care Laws. Each Credit Party and each of its Subsidiaries, and each officer, affiliate and employee
acting on behalf of each Credit Party or any of its Subsidiaries, is in compliance in all material respects with all Health Care Laws applicable to such Credit Party or Subsidiary, its products and its properties or other assets or its business or
operations, including all applicable statutes, rules, regulations, standards, policies and orders administered or issued by any Governmental Authority relating to any of the foregoing. 

(b) Compliance with FDA Laws (and Foreign Equivalents). Each Credit Party and each of its Subsidiaries are in compliance in all
material respects with all applicable FDA Laws, including all applicable requirements of the Food, Drug and Cosmetic Act or any of its implementing regulations (“FDCA”) and all applicable statutes, rules, regulations, standards,
policies and orders administered or issued by any foreign Governmental Authority, relating to any Product or any aspect of the development, Manufacture, production or Commercialization thereof or otherwise. (i) None of the Products are articles
which may not be introduced into interstate commerce pursuant to the requirements of the FDCA (or foreign equivalent), (ii) each Product has been developed, Manufactured or produced in all material respects in accordance with FDA Good Manufacturing
Practices (or any foreign equivalent) and FDA Registration and Listing Requirements (or foreign equivalent) and (iii) each of the Products required to be approved or cleared by the FDA pursuant to the FDCA (or any foreign equivalent) has been so
approved or cleared. 
 (c) Material Statements. None of the Credit Parties or their respective Subsidiaries nor any officer,
affiliate, employee or, to the Knowledge of each Credit Party or any of its Subsidiaries, agent, of any Credit Party or its Subsidiaries, has (i) made an untrue statement of any material fact or fraudulent statement to any Governmental
Authority (including the FDA), (ii) failed to disclose any material fact to any Governmental Authority (including the FDA), or (iii) committed any act, made any statement, or failed to make any statement that, in any such case, at the time such
disclosure was made, could reasonably be expected to constitute a material violation of any Health Care Law or FDA Law. 

  
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 (d) Proceedings; Audits. To the Knowledge of each Credit Party or any of its
Subsidiaries, there are no facts, circumstances or conditions that could reasonably be expected to form the basis for any material investigation, suit, claim, audit, action (legal or regulatory) or proceeding (legal or regulatory) by a
Governmental Authority (other than any routine Quality System Regulation or Good Clinical Practice compliance audits required by the FDA or any routine audits conducted by notified bodies with respect to any foreign good manufacturing practices
requirements) pending or threatened in writing against any Credit Party or any of its Subsidiaries relating to any of the Health Care Laws, FDA Laws or any applicable statutes, rules, regulations, standards, policies or orders administered or issued
by any foreign Governmental Authority. 
 (e) Prohibited Transactions. None of the Credit Parties or their Subsidiaries, or any of
their respective officers, affiliates or employees or, to the Knowledge of each Credit Party or any of its Subsidiaries, any Person acting on behalf of any Credit Party or any of its Subsidiaries, directly or indirectly: (i) offered or
paid any remuneration, in cash or in kind, to, or made any financial arrangements with, any past, present or potential patient, supplier, physician, or contractor, in order to illegally obtain business or payments from such person in material
violation of any Health Care Law; (ii) has given or agreed to give, made, or is party to any illegal Contract to make, any illegal gift or gratuitous payment of any kind, nature or description (whether in money, property or services) to any
past, present or potential patient, supplier, physician, contractor, or any other person in material violation of any Health Care Law; (iii) made or agreed to make, or is party to any Contract to make on behalf of any Credit Party or any of its
Subsidiaries, any contribution, payment or gift of funds or property to, or for the private use of, any governmental official, employee or agent where either the contribution, payment or gift or the purpose of such contribution, payment or gift is
or was a material violation of the laws of any Governmental Authority having jurisdiction over such payment, contribution or gift; (iv) established or maintained any unrecorded fund or asset for any purpose or made any materially misleading,
false or artificial entries on any of its books or records for any reason; or (v) made, or agreed to make, or is party to any Contract to make, any payment to any person with the intention or understanding that any part of such payment would be
in material violation of any Health Care Law or that was used or given for any purpose other than that described in the documents supporting such payment. To the Knowledge of each Credit Party or any of its Subsidiaries, there are no actions
threatened in writing or pending against any Credit Party or any of its Subsidiaries or their Affiliates under any federal or state whistleblower statute, including under the False Claims Act of 1863 (31 U.S.C. § 3729 et seq.). 

(f) Exclusion. None of the Credit Parties or their Subsidiaries, nor any officer, affiliate or employee having authority to act
on behalf of any Credit Party or any of its Subsidiaries has been, or, to the Knowledge of each Credit Party or any of its Subsidiaries, has been threatened in writing to be, (i) excluded from any Governmental Payor Program pursuant to 42
U.S.C. § 1320a-7b and related regulations, (ii) “suspended” or “debarred” from selling products to the U.S. government or its agencies pursuant to the Federal Acquisition Regulation,
relating to debarment and suspension applicable to federal government agencies generally (42 C.F.R. Subpart 9.4), or other Requirements of Law, (iii) debarred, disqualified, suspended or excluded from participation in Medicare, Medicaid or any
other health care program or is listed on the General Services Administration list of excluded parties, nor, to the Knowledge of each Credit Party or any of its Subsidiaries, is any such debarment, disqualification, suspension or exclusion
threatened in writing or pending, or (iv) made a party to any other action by any Governmental Authority that may prohibit the applicable Credit Party or Subsidiary from selling Products or providing services to any governmental or other
purchaser pursuant to any Health Care Laws. 
 (g) HIPAA. Each Credit Party and each of its Subsidiaries is in material compliance
with all applicable foreign, federal, state and local laws and regulations regarding the privacy and security of health information and electronic transactions, including HIPAA, and the provisions of all business associate agreements (as such
term is defined by HIPAA) to which it is a party, if any, and has implemented adequate policies, procedures and training designed to assure continued compliance and to detect non-compliance, to the extent
applicable. To the extent applicable to any Credit Party and for so long as (i) any Credit Party is a “covered entity” as defined in 45 C.F.R. § 160.103, (ii) any Credit Party is a “business associate” as defined in 45
C.F.R. § 160.103, (iii) any Credit Party is subject to or covered by the HIPAA Administrative Requirements codified at 45 C.F.R. Parts 160 & 162 or the HIPAA Security and Privacy Requirements codified at 45 C.F.R. Parts 160 & 164, or
(iv) any Credit Party sponsors any “group health plans” as defined in 45 C.F.R. § 160.103, such Credit Party has: (A) completed thorough 

  
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and detailed surveys, audits, inventories, reviews, analyses and/or assessments, including risk assessments, (collectively “Assessments”) of all material areas of its business
and operations subject to HIPAA or that could be materially and adversely affected by the failure of such Credit Party, or any Person acting on behalf of any Credit Party, as the case may be, to the extent these Assessments are appropriate or
required for such Credit Party to be in material compliance with HIPAA; (B) developed a detailed plan and time line for becoming in material compliance with HIPAA (a “HIPAA Compliance Plan”); and (C) implemented those
provisions of its HIPAA Compliance Plan necessary to ensure that such Credit Party is in material compliance with HIPAA. 
 (h) Corporate
Integrity Agreement. None of the Credit Parties or their Subsidiaries or their Affiliates, nor any officer, director, managing employee or, to the Knowledge of each Credit Party or any of its Subsidiaries, agent (as those terms are
defined in 42 C.F.R. § 1001.1001) thereof, is a party to, or bound by, any order, individual integrity agreement, or corporate integrity agreement with any Governmental Authority concerning compliance with any laws, rules, or regulations,
issued under or in connection with a Governmental Payor Program. 
 (i) Reimbursement Coding. To the extent that any Credit Party or
any of its Subsidiaries provides to its customers or any other Persons reimbursement coding or billing advice, such advice, to the Knowledge of each Credit Party or any of its Subsidiaries, is complete and accurate and conforms to applicable
coding systems. 
 4.21. Regulatory Approvals. 

(a) Schedule 4.21 of the Disclosure Letter contains a list of all Products that have been Commercialized. Each Credit Party and its
Subsidiaries, as applicable, has all Regulatory Approvals necessary to conduct its business in the manner in which such business is currently conducted. Borrower has previously made available to Lender all Regulatory Approvals, all material
correspondence with Regulatory Agencies (including the FDA and any foreign equivalent) with respect to such Regulatory Approvals and all adverse event reports with respect to the Products that have been Commercialized and all requested documents
related to the Products that have been Commercialized, in each case, in the possession and control of Borrower or any of its Subsidiaries. Borrower has not withheld any document or information with respect to the Products that have been
Commercialized that would reasonably be considered to be material to Lender’s decision to provide the financing contemplated by this Agreement. 

(b) Each Credit Party and its Subsidiaries, and, to the Knowledge of each Credit Party or any of its Subsidiaries, each licensee of a Credit
Party or any of its Subsidiaries of any Intellectual Property, are in compliance with, and have complied with, all applicable federal, state, local and foreign laws, rules and regulations, governing its business, including all regulations
promulgated by each applicable Regulatory Agency, the failure of compliance with which could reasonably be expected to result in a Material Adverse Change. No Credit Party or its Subsidiaries has received any written notice from any Regulatory
Agency citing action or inaction by any Credit Party or any of its Subsidiaries that would constitute a violation of any applicable federal, state, local and foreign laws, rules, regulations or standards, which could reasonably be expected to result
in a Material Adverse Change. 
 (c) Without limiting the generality of clause (b) above, to the Knowledge of each Credit Party
or any of its Subsidiaries, any and all studies, tests and preclinical and clinical trials and investigations conducted by or on behalf of the Credit Parties relating to any Product have been, and are being, conducted in all material respects in
accordance with all Requirements of Law, including good clinical practices (including under FDA (and foreign equivalent) regulations (including the requirements set forth in 21 C.F.R. Part 11, Part 50, Part 54, Part 56, Part 812 and Part 814, as
applicable)), good laboratory practices and investigational device exemption requirements; Borrower has previously made available to Lender descriptions of the results of such studies, tests, trials and investigations, which are accurate in all
material respects; and no Credit Party or any of its Subsidiaries has received any notices or correspondence from any applicable Regulatory Agency or comparable authority requiring the termination, suspension, material modification or clinical hold
of any such studies, tests, trials or investigations conducted by or on behalf of a Credit Party or its Subsidiaries, which termination, suspension, material modification or clinical hold could reasonably be expected to result in a Material Adverse
Change. 

  
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 4.22. Supply and Manufacturing. 

(a) To the Knowledge of each Credit Party or any of its Subsidiaries, the development, Manufacturing and production of each Product has at all
times been (i) in compliance in all material respects with the final release quality specifications in effect for such Product and (ii) in compliance in all material respects with Requirements of Law, including the FDCA (and any foreign
equivalent). Except as set forth on Schedule 4.22(a) of the Disclosure Letter, to the Knowledge of each Credit Party or any of its Subsidiaries, no Person currently Manufacturing Product and currently party to a Manufacturing Agreement and,
to the actual knowledge of each Credit Party or any of its Subsidiaries, no other Person Manufacturing Product, in each case has received in the past five (5) years a Form 483 or is currently subject to a Form 483 impacting any Product with
respect to any facility Manufacturing Product and that, with respect to each such Form 483, all scientific and technical violations or other issues relating to good manufacturing practice requirements documented therein, and any disputes regarding
any such violations or issues, have been corrected or otherwise resolved. Each Product that has been Commercialized has at all times been Manufactured in sufficient quantities and of a sufficient quality to satisfy at least the forecasted demand of
such Product (as reasonably determined by a Responsible Officer of Borrower in good faith and based upon reasonable assumptions). 
 (b)
Except as set forth on Schedule 4.22(b) of the Disclosure Letter, (i) no Product has been recalled, suspended or discontinued as a result of any action by the FDA or any other Governmental Authority (or any foreign equivalent), by any
Credit Party or any of its Subsidiaries or by any licensee, distributor or marketer of such Product and (ii) the Credit Parties and their Subsidiaries have maintained global post-marketing surveillance programs and procedures specifically
designed to comprehensively monitor, collect and timely report any medical device reports required to be reported in relation to any of the Products in accordance with any Requirements of Law. To the Knowledge of each Credit Party or any of its
Subsidiaries, there are no facts, circumstances, or conditions that could reasonably be expected to result in a recall, suspension, or discontinuance of any Product. 

(c) Schedule 4.22(c) of the Disclosure Letter contains a true, correct and complete list of all manufacturing and supply Contracts
entered into by any Credit Party or any of its Subsidiaries with third parties and in effect for the supply of Product (the “Manufacturing Agreements”) as of the Tranche A Closing Date. Borrower has previously made available to
Lender true, correct and complete copies of each Manufacturing Agreement. After giving effect to consummation of the transactions contemplated by this Agreement and the other Loan Documents, except as described on Schedule 4.22(c) of the
Disclosure Letter, each Manufacturing Agreement is a valid and binding obligation of the applicable Credit Party or Subsidiary and is in full force and effect, and to the Knowledge of each Credit Party or any of its Subsidiaries, is a valid and
binding obligation of any other party thereto, and neither the applicable Credit Party or its Subsidiaries or, to the Knowledge of each Credit Party or any of its Subsidiaries, any other party thereto is in breach thereof or default thereunder.
Except as described on Schedule 4.22(c) of the Disclosure Letter, no Credit Party or any of its Subsidiaries has received any notice from any party thereto, oral or written, regarding (i) the cancellation, termination or invalidation of
any Manufacturing Agreement or (ii) any indication by or intent or threat of, such party, oral or written, to reduce or cease the supply of Product through calendar year 2022. 

4.23. Additional Representations and Warranties. 

(a) Except as set forth on Schedule 4.23(a) of the Disclosure Letter, after giving effect to consummation of the transactions
contemplated by this Agreement and the other Loan Documents, as of the Tranche A Closing Date, there is no Subordinated Debt. 
 (b) There
are no Hedging Agreements other than Permitted Hedging Agreements. 
 (c) Since December 31, 2016, there shall not have occurred or
failed to occur any change or event that has had or could reasonably be expected to have, either alone or in conjunction with any other change(s), event(s) or failure(s), a Material Adverse Change. 

(d) No Default exists hereunder. 

(e) Neither any Credit Party nor any of its Subsidiaries own or have owned in the past any real property and neither any Credit Party nor any
of its Subsidiaries lease any real property other than the properties subject to the leases set forth in Schedule 4.23(e) of the Disclosure Letter. 

  
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 (f) There are no Consulting Royalties due and payable with respect to any Product and there
are no Contracts pursuant to which any Consulting Royalties will become due and payable with respect to any Product. 
 5. AFFIRMATIVE
COVENANTS 
 Each Credit Party covenants and agrees that, until payment in full of all Obligations (other than inchoate indemnity
obligations), each Credit Party shall, and shall cause each of its Subsidiaries to: 
 5.1. Government Compliance. Except as
permitted in Section 6.3, maintain its and all its Subsidiaries’ legal existence and good standing in their respective jurisdictions of formation and maintain qualification in each other jurisdiction in
which the failure to so qualify could reasonably be expected to result in a Material Adverse Change. Each Credit Party shall (i) comply, and cause each of its Subsidiaries to comply, with all Requirements of Law of any Governmental Authority to
which it is subject, noncompliance with which could reasonably be expected to result, individually or in the aggregate, in a Material Adverse Change, (ii) maintain policies that assure that each of its employees has all required licenses,
credentials, approvals and other certifications to perform his or her duties and (iii) obtain, and take all necessary action to timely renew, all material permits, licenses and authorizations which are necessary in the proper conduct of its
business. 
 5.2. Financial Statements, Compliance Certificates; Notices; Reports. Deliver to Lender: 

(a) Financial Statements; Compliance Certificate; Other Information. 

(i) Annual Financial Statements. So long as Borrower is not a Public Reporting Company, (1) as soon as available,
but in any event within one hundred eighty (180) days after the end of each fiscal year of Borrower, beginning with the fiscal year ending December 31, 2017, a consolidated balance sheet of Borrower and its Subsidiaries as of the end of
such fiscal year, and the related consolidated statements of income, cash flows and stockholders’ equity for such fiscal year, setting forth in each case in comparative form the figures for the previous fiscal year, with such consolidated
financial statements to be audited and accompanied by (A) a report and opinion of Borrower’s independent certified public accounting firm of recognized national or regional standing (which report and opinion shall be prepared in accordance
with Applicable Accounting Standards and shall not be subject to any qualification as to scope of audit, but which may be subject to a qualification as to “going concern”), stating that such financial statements fairly present, in all
material respects, the consolidated financial condition, results of operations and cash flows of Borrower as of the dates and for the periods specified in accordance with Applicable Accounting Standards, and (B) (if and only if Borrower is required
to comply with the internal control provisions pursuant to Section 404 of the Sarbanes-Oxley Act of 2002 requiring an attestation report of such independent certified public accounting firm) an attestation report of such independent certified
public accounting firm as to Borrower’s internal controls pursuant to Section 404 of the Sarbanes-Oxley Act of 2002 attesting that such internal controls meet the requirements of the Sarbanes-Oxley Act of 2002 and (2) as soon as
available, but in any event within sixty (60) days after the end of each fiscal year of Borrower, beginning with the fiscal year ending December 31, 2017, an unaudited consolidated balance sheet of Borrower and its Subsidiaries as of the
end of such fiscal year, and the related unaudited consolidated statements of income, cash flows and stockholders’ equity for such fiscal year, setting forth in each case in comparative form the figures for the previous fiscal year. Each of the
foregoing consolidated financial statements shall be certified by a Responsible Officer as, to his or her knowledge, fairly presenting, in all material respects, the consolidated financial condition, results of operations and cash flows of Borrower
and its Subsidiaries as of the dates and for the periods specified in accordance with Applicable Accounting Standards consistently applied; 

(ii) Quarterly Financial Statements. So long as Borrower is not a Public Reporting Company, as soon as available, but in
any event within sixty (60) days after the end of each of the first three (3) fiscal quarters of each fiscal year of Borrower, beginning with the fiscal quarter ending March 31, 2018, a consolidated balance sheet of Borrower and its
Subsidiaries as of the end of such fiscal quarter, and the related consolidated statements of income and cash flows and for such fiscal quarter and (in respect of the second and third fiscal quarters of such fiscal year) for the then-elapsed portion
of Borrower’s fiscal 

  
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 year, setting forth in each case in comparative form the figures for the comparable period
or periods in the previous fiscal year, subject to normal year-end audit adjustments and the absence of disclosures normally made in footnotes. Such consolidated financial statements shall be certified by a
Responsible Officer as, to his or her knowledge, fairly presenting, in all material respects, the consolidated financial condition, results of operations and cash flows of Borrower and its Subsidiaries as of the dates and for the periods specified
in accordance with Applicable Accounting Standards consistently applied, and on a basis consistent with the audited consolidated financial statements referred to under Section 5.2(a)(i), subject to normal year-end audit adjustments and the absence of footnotes; 
 (iii) Quarterly Compliance
Certificate. As soon as available, but in no event later than sixty (60) days after the last day of each fiscal quarter, commencing with the fiscal quarter ending December 31, 2017, a duly completed Compliance Certificate signed by a
Responsible Officer, among other things (i) certifying that no Event of Default or Default has occurred or, if such an Event of Default or Default has occurred, specifying the nature and extent thereof and any corrective action taken or
proposed to be taken with respect thereto and (ii) setting forth computations in reasonable detail satisfactory to Lender, acting reasonably, demonstrating compliance with the covenants contained in Section 5.12 and
Section 6.17; 
 (iv) SEC Statements. After Borrower becomes a Public Reporting Company:
(A) within five (5) days of filing, access (via posting such reports, or providing a link thereto, on Borrower’s website on the internet at Borrower’s website address) to all reports on Form
10-K and Form 10-Q filed with the SEC, any Governmental Authority succeeding to any or all of the functions of the SEC or with any national securities exchange;
(B) within five (5) days of filing, written notice and access (via posting such reports, or providing a link thereto, on Borrower’s website on the internet at Borrower’s website address) to all reports on Form 8-K filed with the SEC; and (C) copies of (via posting such reports, statements or materials, or providing a link thereto, on Borrower’s website on the internet at Borrower’s website address) all
other reports, proxy statements and other materials filed by Borrower with the SEC, any Governmental Authority succeeding to any of the functions of the SEC or with any national securities exchange; and 

(v) Information during Event of Default. As promptly as practicable (and in any event within five (5) Business Days
of the request therefor), such additional information regarding the business or financial affairs of Borrower or any of its Subsidiaries, or compliance with any of the terms or provisions of this Agreement or any other Loan Document, as Lender may
from time to time reasonably request during the existence of any Event of Default (subject to reasonable requirements of confidentiality, including requirements imposed by law or Contract; provided that Borrower shall not be obligated to
disclose any information that is reasonably subject to the assertion of attorney-client privilege); 
 All statements and certificates (as
applicable) of Borrower and each of its Subsidiaries required to be delivered to Lender pursuant to this Section 5.2(a) will be prepared in conformity with Applicable Accounting Standards (other than any immaterial deviations thereto) applied
on a consistent basis throughout the periods covered thereby and will fairly present in all material respects the consolidated financial condition of Borrower and its Subsidiaries and their consolidated results of operations as of the dates
indicated and the changes in their cash flows for the periods specified (other than any pro forma statements and projections provided to Lender, such pro forma statements and projections representing the best good faith estimates of Borrower and
being based on assumptions believed by Borrower to be fair and reasonable at the time made, and with respect to any such pro forma statements or projections which include adjustments from Applicable Accounting Standards, such adjusted pro forma
statements and projections being in the same format as provided to the audit committee of the Board of Directors); 
 (b) [Reserved];

 (c) Other Statements. So long as Borrower is not a Public Reporting Company, copies of all statements, reports and notices made
available to Borrower’s security holders generally or to any holders of Subordinated Debt, in each case, within five (5) days of delivery to any such Person; 

  
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 (d) Legal Action Notice. As promptly as practicable, a report of any legal action,
litigation, investigation or proceeding pending or, in each case, threatened in writing against any Credit Party or any Subsidiary, or any material development in any such legal action, litigation, investigation or proceeding (i) that could
result in damages or costs to such Credit Party or such Subsidiary in an amount in excess of $250,000, individually, or $500,000, in the aggregate, when aggregated with all pending or threatened (in writing) legal actions against all Credit Parties
and their respective Subsidiaries or (ii) which alleges potential violations of the Health Care Laws, the FDA Laws or any applicable statutes, rules, regulations, standards, policies or orders administered or issued by any foreign Governmental
Authority, which, individually or in the aggregate, could reasonably be expected to have a Material Adverse Change; 
 (e) Consolidated
Plan and Financial Forecast; Board Approved Projections. No later than March 1 of each fiscal year of Borrower, a consolidated plan and financial forecast of Borrower and its Subsidiaries through the Term Loan Maturity Date, including a
forecasted consolidated balance sheet, statements of income and cash flows, and an explanation of the assumptions on which such forecast is based and demonstrating projected compliance with the financial covenants set forth in Sections 5.12
and 6.17 and any amendments thereto or financial projections (or amendments to financial projections) approved by the Board of Directors, whether quarterly or otherwise; 

(f) Other Financial Information. As promptly as practicable, other financial information reasonably requested by Lender; 

(g) Notice of Defaults, Events of Default, ERISA Events and Material Adverse Change. Written notice as promptly as practicable (and in
any event within five (5) Business Days) after a Responsible Officer of Borrower or any of its Subsidiaries shall have obtained knowledge of the occurrence of (i) any Default or Event of Default, (ii) any ERISA Event or (iii) any
event or circumstance that would render the representations and warranties in Section 4.23(c) or the ultimate sentence of Section 4.7(a) untrue if made at such time; 

(h) Intellectual Property; Regulatory. Written notice as promptly as practicable (and in any event no later than five (5) Business
Days) after a Responsible Officer of Borrower or any of its Subsidiaries shall have obtained Knowledge of any of the following: 

(i) any material breach or default by Borrower or any of its Subsidiaries of any covenant, agreement or other provision of
(A) this Agreement or any other Loan Document, or (B) any Current Company IP Agreement or any Material Contract (other than this Agreement or any other Loan Document) that, individually or together with any other such breach or default,
could reasonably be expected to result in a Material Adverse Change; 
 (ii) any license to a third party of any rights to
develop, Manufacture, use or Commercialize the Products in the Territory (other than agreements and arrangements that are Permitted Licenses pursuant to clauses (c) or (d) of the definition thereof); 

(iii) any material breach or default by a counterparty under any Current Company IP Agreement or any Material Contract, or the
termination of any Current Company IP Agreement or Material Contract (irrespective of whether pursuant to the terms thereof), in each case, that, individually or together with any other such breach, default or termination, could reasonably be
expected to result in a Material Adverse Change; 
 (iv) the commencement of any action or proceeding against Borrower or any
of its Subsidiaries which could reasonably be expected to result in a Material Adverse Change, or which challenges the validity of any claim in any Patent within the Company IP utilized in connection with any Product that could reasonably be
expected to materially and adversely affect the exploitation of (including the ability to own or license) such Product by Borrower or any of its Subsidiaries; 

(v) any written notice that the FDA (or foreign equivalent) or other Regulatory Agency is limiting, suspending or revoking any
Regulatory Approval, changing the market classification or labeling of or otherwise materially restricting Manufacture or Commercialization of any Product, or is considering any of the foregoing; 

  
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 (vi) Borrower or any of its Subsidiaries becoming subject to any
administrative or regulatory enforcement action, warning letter or written notice of violation letter from the FDA (or foreign equivalent) or other Regulatory Agency, or any Product of Borrower or any of its Subsidiaries being seized, withdrawn,
recalled, detained or subject to a suspension of Manufacturing, or the commencement of any proceedings in the United States seeking the withdrawal, recall, suspension, import detention or seizure of any Product; or 

(vii) the occurrence of any event (including the occurrence of a Manufacturing disruption) with respect to any Product which
could reasonably be expected to result in a Material Adverse Change. 
 (i) Governmental Recommendations. Within five
(5) Business Days of receipt thereof, copies of any written recommendation from any Governmental Authority or other regulatory body that Borrower or any of its Subsidiaries should have its licensure, provider or supplier number, or
accreditation suspended, revoked, or limited in any material way, or any penalties or sanctions imposed; or 
 (j) Change in Control.

 (i) Written notice promptly, and in any event no later than two (2) Business Days, after the execution of any
definitive acquisition, merger or restructuring agreement, pursuant to which a Change in Control is contemplated to occur, which notice shall include reasonable detail as to the nature, timing and other circumstances of such Change in Control; and

 (ii) A Change in Control Notice promptly, and in any event no later than two (2) Business Days, after the
consummation of a Change in Control. 
 5.3. Inventory; Returns; Maintenance of Properties. Keep all Inventory in good and
marketable condition, free from material defects. Returns and allowances between Borrower and its Account Debtors shall follow Borrower’s customary practices as they exist at the Effective Date and each Credit Party shall promptly notify
Lender in writing of all returns, allowances, recoveries, disputes and claims that involve more than $500,000, individually, or more than $1,000,000, in the aggregate, when aggregated with any and all other returns, allowances, recoveries, disputes
and claims. Each Credit Party will, and will cause each of its Subsidiaries to, maintain or cause to be maintained in good repair, working order and condition, ordinary wear and tear, casualty and condemnation excepted, all material tangible
properties used or useful in its respective business, and from time to time will make or cause to be made all appropriate repairs, renewals and replacements thereof. 

5.4. Taxes; Pensions. Borrower shall timely file, and require each of its Subsidiaries to timely file, all income and other
material required Tax returns and reports or extensions therefor and timely pay, and require each of its Subsidiaries to timely pay, all material foreign, federal, state and local Taxes, assessments, deposits and contributions imposed upon it or any
of its properties or assets or in respect of any of its income, businesses or franchises before any penalty or fine accrue thereon, and all claims (including claims for labor, services, materials and supplies) for sums that have become due and
payable and that by law have or may become a Lien upon any of its properties or assets, prior to the time when any penalty or fine shall be incurred with respect thereto; provided that no such Tax or claim need be paid if it is being
contested in good faith by appropriate proceedings promptly instituted and diligently conducted, so long as (i) adequate reserve or other appropriate provision, as shall be required in conformity with Applicable Accounting Standards shall have
been made therefor and (ii) in the case of a Tax or claim which has or may become a Lien against any of the Collateral, such contest proceedings conclusively operate to stay the sale of any portion of the Collateral to satisfy such Tax or
claim. No Credit Party will, nor will it permit any of its Subsidiaries to, file or consent to the filing of any consolidated income Tax return with any Person (other than Borrower or any of its Subsidiaries). 

  
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 5.5. Insurance. Maintain or cause to be maintained, with financially sound and
reputable insurers, such public liability insurance, third party property damage insurance, business interruption insurance and casualty insurance with respect to liabilities, losses or damage in respect of the assets, properties and
businesses of Borrower and its Subsidiaries as may customarily be carried or maintained under similar circumstances by Persons of established reputation engaged in similar businesses, in each case, in such amounts, with such deductibles, covering
such risks and otherwise on such terms and conditions as shall be customary for such Persons. All property policies of the Credit Parties shall have a loss payable endorsement showing Lender as loss payee and waive subrogation against Lender and
shall provide that the insurer must give Lender at least twenty (20) days’ notice before canceling its policy (or ten (10) days’ notice in the case of the failure to pay any premiums thereunder). At the request of Lender, each
Credit Party shall deliver to Lender copies of policies and evidence of all premium payments. All liability policies of the Credit Parties shall show, or have endorsements showing, Lender as an additional insured, and all such policies (or the loss
payable and additional insured endorsements) shall provide that the insurer shall endeavor to give Lender at least twenty (20) days’ notice before canceling its policy (or ten (10) days’ notice in the case of the failure to pay
any premiums thereunder). If Borrower or any of its Subsidiaries fails to obtain insurance as required under this Section 5.5 or to pay any amount or furnish any required proof of payment to third persons and Lender, upon
the occurrence and during the continuance of an Event of Default, Lender may make all or part of such payment or obtain such insurance policies required in this Section 5.5, and take any action under the policies Lender
deems prudent. Borrower may later cancel any insurance purchased by Lender, but only after providing Lender with evidence that there has been obtained insurance as required in this Section 5.5. No payments by Lender
pursuant to this Section 5.5 are deemed an agreement to make similar payments in the future or Lender’s waiver of any Default or Event of Default. 

5.6. Operating Accounts. In the case of any Credit Party, not establish any new Collateral Account at or with any bank or
financial institution unless contemporaneously with such establishment, such account is subject to a Control Agreement that is reasonably acceptable to Lender. For each Collateral Account that each Credit Party at any time maintains, such Credit
Party shall cause the applicable bank or financial institution at or with which any Collateral Account is maintained to execute and deliver a Control Agreement or other appropriate instrument with respect to such Collateral Account to perfect
Lender’s Lien in such Collateral Account in accordance with the terms hereunder, which Control Agreement may not be terminated without the prior written consent of Lender. The provisions of the previous two (2) sentences shall not apply to
deposit accounts exclusively used for payroll, payroll Taxes and other employee wage and benefit payments to or for the benefit of any Credit Party’s employees, zero balance accounts, accounts (including trust accounts) used exclusively for
escrow, customs, insurance or fiduciary purposes, merchant accounts, accounts used exclusively for compliance with any Requirements of Law to the extent such Requirements of Law prohibits the granting of a Lien thereon and any other deposit accounts
established after the Tranche A Closing Date and then only so long as such deposit accounts do not hold in the aggregate more than $50,000 and for the first thirty (30) days following the establishment of such deposit account (all such
accounts, collectively, the “Excluded Accounts”); provided that, in each case, Borrower shall identify to Lender all accounts which constitute Excluded Accounts. Notwithstanding the foregoing, the Credit Parties shall have
until the date that is ninety (90) days following the closing date of a Permitted Acquisition or other Investment permitted hereunder to comply with the provisions of this Section 5.6 with regard to accounts of the
Credit Parties acquired in connection with such Permitted Acquisition or other Investment. 
 5.7. Protection of Intellectual
Property Rights. 
 (a) (i) Protect, defend and maintain the validity and enforceability of the Company IP material to its business;
(ii) maintain the confidential nature of any material trade secrets and trade secret rights; (iii) promptly advise Lender in writing of material infringements, misappropriations or violations of Intellectual Property owned by any Credit
Party or any of its Subsidiaries; and (iv) except as permitted by Section 6.1(j), not allow any Company IP material to its business to be abandoned, forfeited or dedicated to the public, or any material Current Company
IP Agreement to be terminated by any Credit Party or any of its Subsidiaries, as applicable, without Lender’s prior written consent; provided, however, that with respect to Company IP that is not owned by any Credit Party or its
Subsidiaries, the obligations of each Credit Party or its Subsidiaries in clauses (i) and (iv) above shall apply only to the extent such Credit Party or its Subsidiaries have the right to take such actions or to cause any licensee
or other third party to take such actions pursuant to applicable Contracts or contractual rights. 
 (b) Provide written notice to Lender
within thirty (30) days of entering or becoming bound by any Restricted License (other than over-the-counter software that is commercially available to the public).
Each Credit Party shall take such commercially reasonable steps as Lender requests to obtain the consent of, or waiver by, 

  
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 any Person whose consent or waiver is necessary for (i) any Restricted License to, without giving
effect to Section 9-408 of the Code, be deemed “Collateral” and for Lender to have a security interest in it that might otherwise be restricted or prohibited by law or by the terms of any such
Restricted License, whether now existing or entered into in the future, and (ii) Lender to have the ability in the event of a liquidation of any Collateral to dispose of such Collateral in accordance with Lender’s rights and remedies under
this Agreement and the other Loan Documents. 
 (c) Borrower shall, and shall cause each of its Subsidiaries, as applicable, to: (i) use
commercially reasonable efforts, at its sole expense, either directly or, indirectly with respect to any licensee or licensor under the terms of Borrower’s (or any of its Subsidiary’s) Contract with the respective licensee or licensor, as
applicable, to take any and all actions (including taking legal action to specifically enforce the applicable terms of any license or Contract) and prepare, execute, deliver and file Contracts or documents which are necessary or desirable to
(A) prosecute and maintain the Company IP material to its business and (B) diligently enforce or defend the Company IP against material infringement, misappropriation, violation or interference by any other Persons and, in the case of
Copyrights, Trademarks and Patents within the Company IP, against any claims of invalidity or unenforceability (including by bringing any legal action for infringement, dilution, violation or defending any counterclaim of invalidity or action of a non-Affiliate third party for declaratory judgment of non-infringement or non-interference); (ii) keep Lender reasonably informed by
written notice of any and all of such actions and provide Lender with the opportunity to meaningfully consult with Borrower with respect to the direction thereof and Borrower shall consider all of Lender’s comments in good faith;
provided that such obligations shall be subject to any confidentiality obligations of any Credit Party or any of its Subsidiaries or any protective order binding upon any Credit Party or any of its Subsidiaries; provided,
further, that no Credit Party or any of its Subsidiaries shall be obligated to comply with this clause (ii) to the extent compliance would waive attorney-client privilege; and (iii) not, and shall use commercially reasonable
efforts to cause any licensee or licensor of the Company IP, as applicable, not to, disclaim or abandon, or fail to take any action necessary or desirable to prevent the disclaimer or abandonment of the Company IP, in each case, only if such
disclaimer or abandonment could reasonably be expected to result in a Material Adverse Change. 
 5.8. Litigation Cooperation. From
the date hereof and continuing through the termination of this Agreement, make available to Lender, without expense to Lender, each Credit Party and its officers, employees and agents and such Credit Party’s Books, to the extent that
Lender may deem them reasonably necessary to prosecute or defend any third-party suit or proceeding instituted by or against Lender with respect to any Collateral or relating to such Credit Party. 

5.9. Access to Collateral; Books and Records; Audits. Allow Lender, or its agents, at reasonable times during normal business
hours and upon at least three (3) Business Days’ notice (provided that no notice is required if an Event of Default has occurred and is continuing), to inspect the Collateral and audit and copy any Credit Party’s Books. The
foregoing inspections and audits shall be at Borrower’s expense. Such inspections or audits shall be conducted no more often than once every twelve (12) months unless an Event of Default has occurred and is continuing or such audit reveals
the occurrence of an Event of Default. Borrower shall, and shall cause each of its Subsidiaries to, maintain its Books in such manner as to contain full, true and correct entries of all material dealings and transactions in relation to its business
and activities in conformity with Applicable Accounting Standards and all Requirements of Law. 
 5.10. Use of Proceeds. (a) Use
the proceeds of the Term Loan solely to repay in full the Indebtedness outstanding under the Existing Oxford Loan Agreement and any and all associated costs and expenses and to fund its general business requirements and (b) not use the
proceeds of the Term Loan to purchase or carry, or to reduce or retire or refinance any credit incurred to purchase or carry, any margin stock (within the meaning of Regulations U and X of the Board of Governors of the Federal Reserve System) or to
extend credit to others for the purpose of purchasing or carrying any margin stock, in each case in violation of said Regulations. If requested by Lender, Borrower shall complete and sign Part I of a copy of Federal Reserve Form G-3 referred to in Regulation U and deliver such copy to Lender. 
 5.11. Environmental Disclosure.
Deliver to Lender: 
 (a) as soon as practicable following receipt thereof, copies of all environmental audits, investigations, analyses and
reports of any kind or character, whether prepared by personnel of Borrower or any of its Subsidiaries or by independent consultants, governmental authorities or any other Persons, with respect to significant environmental matters at any Facility or
with respect to any material Environmental Claims; 

  
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 (b) promptly upon a Responsible Officer of any Credit Party or any of its Subsidiaries
obtaining knowledge of the occurrence thereof, written notice describing in reasonable detail (i) any Release required to be reported to any federal, state or local governmental or regulatory agency under any applicable Environmental Laws,
(ii) any remedial action taken by any Credit Party or any other Person in response to (A) any Hazardous Materials Activities, the existence of which, individually or together with any other Hazardous Materials Activities, have a reasonable
possibility of resulting in one or more Environmental Claims that could reasonably be expected to result in a Material Adverse Change or (B) any Environmental Claims which, individually or together with any other Environmental Claims, have a
reasonable possibility of resulting in a Material Adverse Change and (iii) any Credit Party’s discovery of any occurrence or condition on any real property adjoining or in the vicinity of any Facility that could cause such Facility or any part
thereof to be subject to any material restrictions on the ownership, occupancy, transferability or use thereof under any Environmental Laws; 

(c) as soon as practicable following the sending or receipt thereof by any Credit Party or any of its Subsidiaries, a copy of any and all
written communications with respect to (i) any Environmental Claims that, individually or in the aggregate, have a reasonable possibility of resulting in a Material Adverse Change, (ii) any Release required to be reported to any
Governmental Authority, and (iii) any request for information from any Governmental Authority that suggests such authority is investigating whether any Credit Party or any of its Subsidiaries may be potentially responsible for any Hazardous
Materials Activity that, individually or together with any other Hazardous Material Activities, has a reasonable possibility of resulting in a Material Adverse Change; 

(d) prompt written notice describing in reasonable detail (i) any proposed acquisition of stock, assets, or properties by Borrower or any
of its Subsidiaries that could reasonably be expected to (A) expose Borrower or any of its Subsidiaries to, or result in, Environmental Claims that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse
Change or (B) affect the ability of Borrower or any of its Subsidiaries to maintain in full force and effect all material Governmental Approvals required under any Environmental Laws for their respective operations and (ii) any proposed
action to be taken by Borrower or any of its Subsidiaries to modify current operations in a manner that, individually or together with any other such proposed actions, could reasonably be expected to subject Borrower or any of its Subsidiaries to
any additional material obligations or requirements under any Environmental Laws; and 
 (e) with reasonable promptness, such other documents
and information as from time to time may be reasonably requested by Lender in relation to any matters disclosed pursuant to this Section 5.11. 

Each Credit Party shall, and shall cause each of its Subsidiaries to, promptly take any and all actions necessary to (x) cure any
violation of applicable Environmental Laws by Borrower or any of its Subsidiaries that, individually or in the aggregate, could reasonably be expected to result in a Material Adverse Change, and (y) make an appropriate response to any
Environmental Claim against Borrower or any of its Subsidiaries and discharge any obligations it may have to any Person thereunder where failure to do so, individually or in the aggregate, could reasonably be expected to result in a Material Adverse
Change. 
 5.12. Minimum Liquidity. From and after the Tranche A Closing Date, after giving effect to the transactions
contemplated hereunder and under the other Loan Documents, Borrower and its Subsidiaries that are Credit Parties shall have consolidated Liquidity, tested as of the end of each Business Day, of not less than Five Million Dollars ($5,000,000.00).
Borrower shall deliver to Lender written notice, as promptly as practicable (and in any event within five (5) Business Days) after the occurrence, of the results of any such minimum Liquidity test which indicate that Borrower and its
Subsidiaries that are Credit Parties have consolidated Liquidity, as of the applicable date of determination, of less than Five Million Dollars ($5,000,000.00). For the avoidance of doubt, no Credit Party shall be required to maintain a restricted
account for purposes of complying with this Section 5.12. 
 5.13. Further Assurances. Subject to the
limitations in Section 5.14(b), at any time or from time to time upon the reasonable request of Lender, each Credit Party will, at its expense, promptly execute, acknowledge and deliver such further documents
and do such other acts and things as Lender may reasonably request in order to effectuate the transactions contemplated by the Loan Documents, including taking such steps as are reasonably deemed necessary by Lender to maintain, protect and enforce
Lender’s Lien on Collateral securing the Obligations created under the Security Agreement and the other Loan Documents. 

  
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 5.14. Additional Collateral; Guarantors. 

(a) Without limiting the generality of Section 5.13 and except as otherwise approved in writing by Lender, the Credit Parties shall cause
each of their respective Domestic Subsidiaries (other than Excluded Subsidiaries and any Domestic Subsidiary that is a CFC Holding Company) to, in each case, guarantee the Obligations and to cause each such Domestic Subsidiary to grant to Lender a
first priority security interest in and Lien upon, and pledge to Lender, subject to Permitted Liens, the limitations set forth herein and the limitations set forth in the other Loan Documents, all of such Domestic Subsidiary’s properties and
assets, whether now existing or hereafter acquired or existing, constituting Collateral to secure such guaranty. Furthermore, and except as otherwise approved in writing by Lender on a
case-by-case basis, each Credit Party shall, and shall cause each of its Domestic Subsidiaries (excluding Excluded Subsidiaries and any Domestic Subsidiary that is a CFC
Holding Company) to, (i) grant Lender a first priority security interest in and Lien upon, and pledge to Lender, subject to Permitted Liens, the limitations set forth herein and the limitations set forth in the other Loan Documents, all of the
Equity Interests (other than Excluded Equity Interests) of each of its Domestic Subsidiaries (other than any Excluded Subsidiary and any Domestic Subsidiary that is a CFC Holding Company) and (ii) grant Lender a first priority security interest
in and Lien upon, and pledge to Lender, subject to Permitted Liens, the limitations set forth herein and the limitations set forth in the other Loan Documents, sixty-five percent (65%) of the issued and outstanding voting Equity Interests (other
than Excluded Equity Interests) and one hundred percent (100%) of the issued and outstanding non-voting Equity Interests (other than Excluded Equity Interests), if any, in, each Foreign Subsidiary and CFC
Holding Company directly owned by any such Domestic Subsidiaries. In connection with each pledge of certificated Equity Interests required under the Loan Documents, the Credit Parties shall deliver, or cause to be delivered, to Lender, such
certificate(s) together with stock powers or assignments, as applicable, properly endorsed for transfer to Lender or duly executed in blank, in each case reasonably satisfactory to Lender. In connection with each pledge of uncertificated Equity
Interests required under the Loan Documents, the Credit Parties shall deliver, or cause to be delivered, to Lender such Equity Interests in accordance with Section 8-106(c)(1) of the Code or an executed
uncertificated stock control agreement among the issuer, the registered owner and Lender in the form attached to the Security Agreement as Annex 4. In the event any Credit Party acquires any fee title to real estate with a fair market value in
excess of $1,000,000, unless otherwise agreed by Lender, such Person shall execute or deliver, or cause to be executed or delivered, to Lender, (v) within sixty (60) days after such acquisition, an appraisal complying with the Financial
Institutions Reform, Recovery and Enforcement Act of 1989, (w) within forty-five (45) days after receipt of notice from Lender that such real estate is located in a Special Flood Hazard Area, Federal Flood Insurance, (x) within sixty
(60) days after such acquisition, a fully executed Mortgage, in form and substance reasonably satisfactory to Lender, together with an A.L.T.A. lender’s title insurance policy issued by a title insurer reasonably satisfactory to Lender, in
form and substance (including any endorsements) and in an amount reasonably satisfactory to Lender insuring that the Mortgage is a valid and enforceable first priority Lien on the respective property, free and clear of all defects, encumbrances and
Liens (other than Permitted Liens), (y) simultaneously with such acquisition, then-current A.L.T.A. surveys, certified to Lender by a licensed surveyor sufficient to allow the issuer of the lender’s title insurance policy to issue such policy
without a survey exception and (z) within sixty (60) days after such acquisition, an environmental site assessment prepared by a qualified firm reasonably acceptable to Lender, in form and substance satisfactory to Lender. 

(b) Notwithstanding anything to the contrary herein, in no event shall any Credit Party or any Subsidiary be required to (i) enter into
or deliver any foreign law-governed documents, file or record any documents or agreements (including any agreements relating to Intellectual Property) with any foreign Governmental Authority or take any other
actions under foreign law with respect to Collateral held outside the United States except as upon the occurrence and during the continuance of an Event of Default and then only if and to the extent then-requested in writing by Lender, or
(ii) deliver any bailee agreements in respect of Inventory or Equipment held by sales representatives or customers. 
 5.15.
Formation or Acquisition of Subsidiaries. Subject to the limitations in Section 5.14(b), if Borrower or any of its Subsidiaries at any time after the Tranche A Closing Date forms or acquires a Subsidiary,
concurrently therewith, Borrower will notify Lender in writing regarding such formation or acquisition and, as promptly as practicable and in no event later than thirty (30) days after such formation or acquisition: (a) if such 

  
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 Subsidiary is a Domestic Subsidiary that is not an Excluded Subsidiary or a CFC Holding Company,
(i) Borrower will cause such Subsidiary to execute and deliver to Lender a joinder to the Security Agreement and, if applicable, the IP Agreements and any other relevant Collateral Document, (ii) without limiting clause (a)(i)
above, such Subsidiary will, and Borrower will cause such Subsidiary to, satisfy all conditions and requirements contained in this Agreement (including Section 5.14) and each other Loan Document (including the Security
Agreement) if and to the extent applicable to such Subsidiary, (iii) Borrower will deliver a certificate executed by a Responsible Officer of Borrower or such Subsidiary that all such conditions and requirements have been satisfied (such
certificate to be in form and substance reasonably satisfactory to Lender) and (iv) such Subsidiary shall constitute a Guarantor and a Credit Party for all purposes hereunder as of the date of formation or acquisition of such Subsidiary; (b)
Borrower will deliver to Lender (i) true, correct and complete copies of the Operating Documents of such Subsidiary, (ii) a Secretary’s Certificate, certifying that the copies of such Operating Documents are true, correct and complete
(such Secretary’s Certificate to be in form and substance reasonably satisfactory to Lender) and (iii) a good standing certificate (or equivalent certification if available in the case of a Subsidiary that is incorporated or organized
under the laws of a jurisdiction other than the United States) for such Subsidiary, certified by the Secretary of State (or the equivalent thereof) of its jurisdiction of incorporation or organization; and (c) Borrower will deliver to Lender a
Perfection Certificate, updated to reflect the formation or acquisition of such Subsidiary. Any document or Contract executed or issued pursuant to this Section 5.15 shall be a Loan Document. 

5.16. Post-Closing Requirements. Borrower will, and will cause each of its Subsidiaries to, take each of the actions set forth
on Schedule 5.16 of the Disclosure Letter within the time period prescribed therefor on such schedule, which shall include, among other things, (a) delivery to Lender of true, correct and complete copies of each Control Agreement
required by Lender hereunder and executed and delivered by each applicable Credit Party (which shall be in form and substance reasonably satisfactory to Lender); (b) use of commercially reasonable efforts to deliver a landlord’s consent in
favor of Lender for each Credit Party’s leased locations by the respective landlord thereof (which consent shall include an agreement by such landlord to permit reasonable access to such leased premises by Lender or its agents upon an Event of
Default for purposes of removal of any and all Collateral, if such leased premises is a warehouse, distribution center or other location at which a material amount of Collateral is located), together with the duly executed original signatures
thereto (which shall be in form and substance reasonably satisfactory to Lender); and (c) use of commercially reasonable efforts to deliver a bailee waiver from each bailee in possession of any Collateral (which bailee waivers shall be
reasonably satisfactory in form and substance to Lender); provided that no Credit Party shall be required to use commercially reasonable efforts to deliver any bailee agreements in respect of Inventory or Equipment held by sales
representatives or customers. All representations and warranties contained in this Agreement and the other Loan Documents shall be deemed modified to the extent necessary to take the actions set forth on Schedule 5.16 of the Disclosure Letter
within the time periods set forth therein, rather than elsewhere provided in the Loan Documents). 
 5.17. Commercialization. Each of
Borrower and its Subsidiaries shall use commercially reasonable efforts to (a) Commercialize the Products and (b) otherwise fully exploit the market potential of the Products in the Territory. In connection therewith, from and after
the Tranche A Closing Date through December 31, 2022, the Products will be Manufactured in sufficient quantities and of a sufficient quality to satisfy at least the forecasted demand of the Products (as reasonably determined by a Responsible
Officer of Borrower in good faith and based upon reasonable assumptions). 
 5.18. Lender Meetings. Upon the request of Lender,
participate in a meeting with Lender once during each fiscal year to be held at Borrower’s corporate offices (or at such other location as may be agreed to by Borrower and Lender) at such time as may be agreed to by Borrower and Lender.

 6. NEGATIVE COVENANTS 

Each Credit Party covenants and agrees that, until payment in full of all Obligations (other than inchoate indemnity obligations), such Credit
Party shall not, and shall cause each of its Subsidiaries not to: 
 6.1. Dispositions. Convey, sell, exchange, lease, transfer,
assign, exclusively license out, non-exclusively license out, agree to any covenant not to sue, enter into a co-existence Contract or otherwise dispose of (including any
sale-leaseback), directly or indirectly and whether in one or a series of transactions, all or any part of its properties or assets (collectively, “Transfer”), except for the following (collectively, “Permitted
Transfers”): 

  
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 (a) Transfers of Inventory in the ordinary course of business (including between Credit
Parties and Subsidiaries which are not Credit Parties; provided that such Transfers are on a cost-plus basis); 
 (b) Transfers of
surplus, damaged, worn out or obsolete Equipment that is, in the reasonable judgment of Borrower exercised in good faith, no longer economically practicable to maintain or useful in the ordinary course of business and Transfers of other properties
or assets in lieu of any pending or threatened institution of any proceedings for the condemnation or seizure of such properties or assets or for the exercise of any right of eminent domain; 

(c) Permitted Licenses; 
 (d)
Transfers made in connection with Permitted Liens and Permitted Investments and Transfers permitted by Sections 6.3, 6.6(b), 6.8, 6.9 and 6.10; 

(e) Transfers consisting of licenses or covenants not to sue made in connection with the settlement of the litigation matters described on
Schedule 4.6 of the Disclosure Letter or about which Lender receives written notice pursuant to Section 5.2(d); 

(f) Transfers of cash and Cash Equivalents in a manner that is not prohibited by the terms of this Agreement or the other Loan Documents; 

(g) (i) Transfers between or among Credit Parties and (ii) Transfers between or among non-Credit Parties; 

(h) the sale or issuance of Equity Interests of any Subsidiary of Borrower to any Credit Party or to any other Subsidiary of Borrower; 

(i) the sale or discount without recourse of accounts receivable arising in the ordinary course of business in connection with the compromise
or collection thereof; 
 (j) any abandonment, cancellation, non-renewal or discontinuance of use or
maintenance of Intellectual Property (or rights relating thereto) of Borrower and its Subsidiaries that Borrower reasonably determines in good faith is no longer economically practicable to maintain or useful in the ordinary course of business and
that is not adverse to the rights, remedies and benefits available to, or conferred upon, Lender under any Loan Document in any material respect or otherwise does not materially diminish the value of the Collateral securing the Obligations; 

(k) the granting of Consulting Royalties; 

(l) Transfers in connection with the cancellation by Borrower of Indebtedness owed to Borrower listed on Schedule 6.1(l) of the
Disclosure Letter; 
 (m) intercompany licenses or grants of distribution, co-product or similar
commercial rights relating to Intellectual Property between or among the Credit Parties and their Subsidiaries, in each case as to geography other than the United States; 

(n) other Transfers made in the ordinary course of business on commercially reasonable arm’s length terms; and 

(o) other Transfers in which such Credit Party will receive cash proceeds in an amount equal to no less than seventy-five percent (75%) of all
Transfer consideration (fixed or contingent) paid or payable to such Credit Party or Subsidiary, but only so long as the net cash proceeds of such Transfer are utilized to repay or prepay, in whole or in part, Indebtedness to Lender under and in
accordance with this Agreement and the other Loan Documents. 

  
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 Except as otherwise expressly permitted under this Agreement, no Transfer of all or any part of the
properties or assets of any Credit Party to any Affiliate of Borrower that is not a Credit Party shall constitute a Permitted Transfer without the prior written consent of Lender. 

6.2. Changes in Business, Management or Business Locations. (a) (i) Engage in any business other than the types of
businesses engaged in by such Credit Party and its Subsidiaries on the Tranche A Closing Date or that are reasonably similar, related, complementary, ancillary or incidental thereto or (ii) in the case of Borrower, have a change in chief
executive officer or chief financial officer and, to the extent that Borrower’s Board of Directors determines a replacement is necessary, a replacement satisfactory to Borrower’s Board of Directors is not made within ninety (90) days
after such individual’s departure. 
 (b) Without at least twenty (20) days’ prior written notice to Lender: (i) change
such Credit Party’s jurisdiction of organization, (ii) change such Credit Party’s organizational structure or type, (iii) change such Credit Party’s legal name, or (iv) change any organizational number (if any) assigned
by such Credit Party’s jurisdiction of organization. 
 (c) Deliver any portion of the Collateral to one or more bailees or leased
locations if the aggregate value of such portion of Collateral, individually or together with any other Collateral at such location(s), is in excess of $1,000,000 (as reasonably determined by a Responsible Officer of Borrower in good faith and based
upon reasonable assumptions), unless such Credit Party shall have used commercially reasonable efforts to deliver to Lender: 

(i) Subject to Section 5.14(b), a bailee agreement in form and substance reasonably satisfactory to
Lender within thirty (30) days of such delivery of Collateral; or 
 (ii) A landlord’s consent in favor of Lender
in form and substance reasonably satisfactory to Lender within thirty (30) days of such delivery of Collateral. 
 6.3.
Mergers, Acquisitions, Liquidations or Dissolutions. 
 (a) Merge, consolidate, liquidate or dissolve with or into any other
Person, except that: 
 (i) any Subsidiary of Borrower that is a Credit Party may merge or consolidate with Borrower or any
other Subsidiary of Borrower that is a Credit Party; provided that Borrower or such other Credit Party is the surviving entity; 

(ii) any Subsidiary of Borrower that is not a Credit Party may merge or consolidate with another Subsidiary of Borrower that is
not a Credit Party; 
 (iii) any Subsidiary of Borrower that is not a Credit Party may merge or consolidate with a Credit
Party; provided that such Credit Party is the surviving entity; 
 (iv) any Subsidiary of Borrower may be dissolved or
liquidated; provided that any and all of the properties and assets of such Subsidiary are distributed to one or more Credit Parties or a Subsidiary that is not a Credit Party if the dissolved Subsidiary is not a Credit Party; 

(v) any Credit Party may merge, consolidate or dissolve with or into any Person in connection with a Permitted Acquisition;
provided, however, that such Person (1) is at the time of such transaction a Credit Party or (2) in connection with the consummation of such transaction, (A) executes and delivers to Lender a joinder to the Security
Agreement and, if applicable, the IP Agreements and any other relevant Collateral Document, (B) without limiting sub-clause (A) above, satisfies all conditions and requirements contained in this
Agreement (including Section 5.14) and each other Loan Document (including the Security Agreement) if and to the extent applicable to such Person, (C) delivers a certificate executed by a Responsible Officer of such
Person that all such conditions and requirements have been satisfied (such certificate to be in form and substance reasonably satisfactory to Lender) and (D) shall constitute a Guarantor and a Credit Party for all purposes hereunder as of the
date of consummation of such transaction; 

  
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 (vi) any Subsidiary that is not a Credit Party may merge, consolidate or
dissolve with or into any Person in connection with a Permitted Acquisition; and 
 (vii) any Investment permitted by
Section 6.8 may be structured as a merger or consolidation; or 
 (b) make, or permit any of its Subsidiaries to
make, Acquisitions outside the ordinary course of business, including any purchase of the assets of any division or line of business of any other Person, other than Permitted Acquisitions or Permitted Investments. 

6.4. Indebtedness. Directly or indirectly, create, incur, assume or guaranty, or otherwise become or remain directly or
indirectly liable with respect to, any Indebtedness, other than Permitted Indebtedness. 
 6.5. Encumbrance. Except for Permitted
Liens, create, incur, allow, or suffer to exist any Lien on any of its properties or assets, or assign or convey any right to receive income (except as permitted by Section 6.1 or in connection with royalties payable
in connection with any Permitted Acquisition), including the sale of any Accounts (except as permitted by Section 6.1), or permit any Collateral not to be subject to the first priority security interest granted in the
Security Agreement or otherwise pursuant to the other Collateral Documents (except for Permitted Liens that are permitted by the terms of this Agreement to have priority over Lender’s Lien). The parties hereto acknowledge and agree that at all
times prior to the Tranche A Closing Date, this covenant shall not apply to Company IP to the extent the application of this covenant would violate the terms of the Existing Oxford Loan Agreement. 

6.6. No Further Negative Pledges; Negative Pledge. 

(a) Enter into any Contract or document directly or indirectly prohibiting or limiting the assignment, mortgage or pledge of, or the grant of a
security interest in or the creation, incurrence or existence of any Lien upon, any of its properties or assets, whether now owned or hereafter acquired, to or in favor of Lender pursuant to the Loan Documents, except with respect to the following:

 (i) specific properties or assets encumbered by Permitted Liens to secure payment of Permitted Indebtedness (including the
Permitted Indebtedness set forth in clause (e) of the definition of “Permitted Indebtedness”), if and only to the extent each such prohibition or limitation applies only to such properties or assets; 

(ii) prohibitions or limitations set forth in any Contract relating to unsecured Permitted Indebtedness or the Permitted
Indebtedness set forth in clause (e) of the definition of “Permitted Indebtedness”, in the case of each such Contract if and only to the extent such prohibitions or limitations, taken as a whole, are not materially more
restrictive than the prohibitions and limitations set forth in this Agreement or any other Loan Document, taken as a whole (as reasonably determined by a Responsible Officer of Borrower in good faith); 

(iii) customary provisions restricting assignments, subletting, sublicensing or other transfer of property subject thereto set
forth in leases, subleases, licenses (including Permitted Licenses), asset sale agreements and other similar Contracts that are not prohibited under this Agreement or any other Loan Document, if and only to the extent each such restriction applies
only to the properties or assets subject to such leases, subleases, licenses, agreements or Contracts; 
 (iv) prohibitions
or limitations on the transfer or assignment of any properties, assets or Equity Interests set forth in any Contract entered into in the ordinary course of business that is not prohibited under this Agreement or any other Loan Document (including
Section 6.6(b) below, if applicable), if and only to the extent each such prohibition or limitation applies only to such properties, assets or Equity Interests; 

  
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 (v) prohibitions or limitations imposed by Requirements of Law; 

(vi) prohibitions or limitations that exist as of the Tranche A Closing Date under Indebtedness existing on the Tranche A
Closing Date (set forth on Schedule 13.1 of the Disclosure Letter); provided, however, that at all times prior to the Tranche A Closing Date, this covenant shall not apply to Company IP to the extent the application of this
covenant would violate the terms of the Existing Oxford Loan Agreement; 
 (vii) customary provisions in shareholders
agreements, joint venture agreements, organizational documents or similar binding Contracts relating to any joint venture entity or non-Wholly-Owned Subsidiary and applicable solely to such joint venture
entity or non-Wholly-Owned Subsidiary and the Equity Interests issued thereby; 

(viii) customary net worth provisions set forth in real property leases entered into by Subsidiaries of Borrower, so long as
such net worth provisions could not reasonably be expected to impair the ability of Borrower or its Subsidiaries to meet their ongoing obligations (as reasonably determined by a Responsible Officer of Borrower in good faith); 

(ix) customary net worth provisions set forth in customer Contracts entered into in the ordinary course of business that are
not prohibited under this Agreement or any other Loan Document, so long as such net worth provisions could not reasonably be expected to impair the ability of Borrower or its Subsidiaries to meet their ongoing obligations (as reasonably determined
by a Responsible Officer of Borrower in good faith); 
 (x) restrictions on cash or other deposits (including escrowed funds)
imposed by Contracts entered into in the ordinary course of business that are not otherwise not prohibited under this Agreement or any other Loan Document; 

(xi) prohibitions or limitations set forth in any Contract in effect at the time any Person becomes a Subsidiary (but not any
amendment, modification, restatement, renewal, extension, supplement or replacement expanding the scope of any such restriction or condition); provided that such Contract was not entered into in contemplation of such Person becoming a
Subsidiary and each such prohibition or limitation does not apply to Borrower or any other Subsidiary (other than such Person and any other Person that is a Subsidiary of such first Person at the time such first Person becomes a Subsidiary); 

(xii) prohibitions or limitations imposed by any Loan Document; 

(xiii) customary provisions set forth in joint venture agreements or Contracts governing minority investments that are not
prohibited by this Agreement or any other Loan Document, if and only to the extent each such prohibition or limitation applies only to the joint venture entity or minority investment that is the subject of such agreement or Contract; and 

(xiv) prohibitions or limitations imposed by any amendments, modifications, restatements, renewals, extensions, supplements or
replacements of any of the Contracts referred to in clauses (i) through (xiii) above, except to the extent that any such amendment, modification, restatement, renewal, extension, supplement or replacement expands the scope of any
such prohibition or limitation. 
 (b) Except as permitted by Section 6.1(h), Transfer or create, incur, allow or
suffer to exist any Lien on, any Equity Interests constituting Collateral issued by any Subsidiary which are owned or otherwise held by such Credit Party or any Subsidiary thereof, except for any Lien or claim in favor of Lender pursuant to the Loan
Documents, any Permitted Lien and sales, assignments, transfers, exchanges or other dispositions to qualify directors if required by Requirements of Law or otherwise permitted under this Agreement; provided that, in the case of sales,
assignments, transfers, exchanges or other dispositions to qualify directors as required by Requirements of Law, such sale, assignment, transfer, exchange or other disposition shall be for the minimum number of Equity Interests as are necessary for
such qualification under Requirements of Law. 

  
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 6.7. Maintenance of Collateral Accounts. Maintain any Collateral Account except
pursuant to the terms of Section 5.6 hereof. 
 6.8. Distributions; Investments. (a) Pay any dividends or
make any distribution or payment on or redeem, retire or purchase any capital stock, except for the following: 
 (i)
The conversion by Borrower of any of its convertible securities into other securities pursuant to the terms of such convertible securities or otherwise in exchange thereof; 

(ii) The payment of dividends by Borrower solely in non-cash pay and non-redeemable capital stock (including, for the avoidance of doubt, dividends and distributions payable solely in Equity Interests); 

(iii) The redemption or repurchase of Equity Interests by Borrower from current or former officers, employees, directors and
consultants of Borrower, so long as (A) an Event of Default does not exist at the time of such redemption or repurchase and would not exist after giving effect to such redemption or repurchase and (B) the amount paid for all such
redemptions and repurchases shall not exceed $500,000 in the aggregate, in any fiscal year of Borrower; 
 (iv) The
repurchase or other acquisition of Equity Interests deemed to occur (A) upon the exercise of stock options, warrants, restricted stock units or other rights to purchase Equity Interests if such Equity Interests represent a portion of the
exercise price thereof or conversion price thereof and (B) in connection with any tax withholding imposed, levied, collected, withheld or assessed by any Governmental Authority upon the grant of or any exercise or vesting of any Equity
Interests (or options in respect thereof) of current or former officers, employees, directors and consultants of Borrower; 

(v) Cash payments in lieu of the issuance of fractional shares in connection with the exercise of warrants, options or other
securities convertible into or exchangeable for Equity Interests; 
 (vi) In connection with any Permitted Acquisition by
Borrower or any of its Subsidiaries, (A) the receipt or acceptance of the return to Borrower or any of its Subsidiaries of Equity Interests of Borrower constituting a portion of the purchase price consideration in settlement of indemnification
claims, or as a result of a purchase price adjustment (including earn-outs or similar obligations) and (B) payments or distributions to equity holders pursuant to appraisal rights required under Requirements of Law; and 

(vii) The distribution of rights pursuant to any shareholder rights plan or the redemption of such rights for nominal
consideration in accordance with the terms of any shareholder rights plan; or 
 (b) Directly or indirectly (including by the formation of
any Subsidiary) make any Investment other than Permitted Investments. 
 Notwithstanding the foregoing, (x) Subsidiaries shall be permitted to pay
dividends or make distributions to any Credit Party, and (y) Subsidiaries that are not Credit Parties shall be permitted to pay dividends or make distributions to other Subsidiaries that are not Credit Parties. 

6.9. Restrictions on Subsidiary Distributions. Create or otherwise cause or suffer to exist or become effective any consensual
encumbrance or restriction of any kind on the ability of any Subsidiary of Borrower to (a) pay dividends or make any other distributions on any of such Subsidiary’s Equity Interests owned by Borrower or any other Subsidiary of Borrower,
(b) repay or prepay any Indebtedness owed by such Subsidiary to Borrower or any other Subsidiary of Borrower, (c) make loans or advances to Borrower or any other Subsidiary of Borrower, or (d) Transfer any of its properties or assets to
Borrower or any other Subsidiary of Borrower, other than any of the following restrictions or encumbrances, as applicable: 

  
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 (i) encumbrances of specific properties or assets under Permitted Liens to
secure payment of Permitted Indebtedness (including the Permitted Indebtedness set forth in clause (e) of the definition of “Permitted Indebtedness”), if and only to the extent each such encumbrance applies only to such
properties or assets; 
 (ii) restrictions or encumbrances set forth in any Contract relating to unsecured Permitted
Indebtedness or the Permitted Indebtedness set forth in clause (e) of the definition of “Permitted Indebtedness”, in the case of each such Contract if and only to the extent such prohibitions or limitations, taken as a whole,
are not materially more restrictive than the prohibitions and limitations set forth in this Agreement or any other Loan Document, taken as a whole (as reasonably determined by a Responsible Officer of Borrower in good faith); 

(iii) customary provisions restricting assignments, subletting, sublicensing or other transfer of property subject thereto set
forth in leases, subleases, licenses (including Permitted Licenses), asset sale agreements and other similar Contracts that are not prohibited under this Agreement or any other Loan Document, if and only to the extent each such restriction applies
only to the properties or assets subject to such leases, subleases, licenses, agreements or Contracts; 
 (iv) restrictions
or encumbrances on the transfer or assignment of any properties, assets or Equity Interests set forth in any Contract entered into in the ordinary course of business that is not prohibited under this Agreement or any other Loan Document, if and only
to the extent each such restriction or encumbrance applies only to such properties, assets or Equity Interests; 
 (v)
restrictions or encumbrances imposed by Requirements of Law; 
 (vi) restrictions or encumbrances that exist as of the
Tranche A Closing Date under Indebtedness existing on the Tranche A Closing Date (set forth on Schedule 13.1 of the Disclosure Letter); provided, however, that at all times prior to the Tranche A Closing Date, this covenant
shall not apply to Company IP to the extent the application of this covenant would violate the terms of the Existing Oxford Loan Agreement; 

(vii) customary provisions in shareholders agreements, joint venture agreements, organizational documents or similar binding
Contracts relating to any joint venture entity or non-Wholly-Owned Subsidiary and applicable solely to such joint venture entity or non-Wholly-Owned Subsidiary and the
Equity Interests issued thereby; 
 (viii) customary net worth provisions contained in real property leases entered into by
Subsidiaries of Borrower, so long as such net worth provisions could not reasonably be expected to impair the ability of Borrower or its Subsidiaries to meet their ongoing obligations (as reasonably determined by a Responsible Officer of Borrower in
good faith); 
 (ix) customary net worth provisions set forth in customer Contracts entered into in the ordinary course of
business that are not prohibited under this Agreement or any other Loan Document, so long as such net worth provisions could not reasonably be expected to impair the ability of Borrower or its Subsidiaries to meet their ongoing obligations (as
reasonably determined by a Responsible Officer of Borrower in good faith); 
 (x) restrictions on cash or other deposits
(including escrowed funds) imposed by Contracts entered into in the ordinary course of business that are not otherwise not prohibited under this Agreement or any other Loan Document; 

(xi) restrictions or encumbrances set forth in any Contract in effect at the time any Person becomes a Subsidiary (but not any
amendment, modification, restatement, renewal, extension, supplement or replacement expanding the scope of any such restriction or condition); provided that such Contract was not entered into in contemplation of such Person becoming a
Subsidiary and each such prohibition or limitation does not apply to Borrower or any other Subsidiary (other than such Person and any other Person that is a Subsidiary of such first Person at the time such first Person becomes a Subsidiary); 

  
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 (xii) restrictions or encumbrances imposed by any Loan Document; 

(xiii) customary provisions set forth in joint venture agreements or Contracts governing minority investments that are not
prohibited by this Agreement or any other Loan Document, if and only to the extent each such restriction or encumbrance applies only to the joint venture entity or minority investment that is the subject of such agreement or Contract; and 

(xiv) restrictions or encumbrances imposed by any amendments, modifications, restatements, renewals, extensions, supplements or
replacements of any of the Contracts referred to in clauses (i) through (xiii) above, except to the extent that any such amendment, modification, restatement, renewal, extension, supplement or replacement expands the scope of any
such restriction or encumbrance. 
 6.10. Transactions with Affiliates. Directly or indirectly enter into or permit to exist any
material transaction with any Affiliate of any Credit Party or any owner of ten percent (10%) or more of the Equity Interests of any Credit Party or any of its Subsidiaries, except for: 

(a) transactions that are in the ordinary course of such Credit Party’s or Subsidiary’s business consistent with past practice, upon
fair and reasonable terms that are no less favorable to such Credit Party or Subsidiary than would be obtained in an arm’s length transaction with a non-affiliated Person, in each case as reasonably
determined by a Responsible Officer of Borrower in good faith; 
 (b) any transaction between or among any Credit Party and its Subsidiaries
not prohibited by this Agreement or any other Loan Document; 
 (c) reasonable and customary compensation arrangements (including fees,
benefits, severance, change of control payments and incentive arrangements) for members of the Board of Directors of Borrower and its Subsidiaries (or similar governing body) in the ordinary course of business; 

(d) reasonable compensation arrangements (including fees, benefits, severance, change of control payments and incentive arrangements) for
officers, employees, consultants and agents of Borrower and its Subsidiaries entered into in the ordinary course of business; 
 (e)
Investments permitted under clauses (a), (e), (f), (g), (k), (l), (m), (o), (p) and (q) of the definition of Permitted Investments; 

(f) Investments in Borrower comprised of the proceeds of equity financings and the granting of registration and other customary rights in
connection therewith, any contribution to the Equity Interests of Borrower or any of its Subsidiaries and unsecured debt financings from Borrower’s shareholders, in each case, if and only to the extent any and all such Indebtedness is
Subordinated Debt and does not violate Section 6.5; 
 (g) transactions pursuant to a Contract in existence at the
time any Credit Party or Subsidiary of a Credit Party that is a party to such transaction is acquired pursuant to a Permitted Acquisition or similar Investment permitted by Section 6.8; 

(h) any transaction in connection with Contracts existing on the Tranche A Closing Date and set forth on Schedule 4.14 of the Disclosure
Letter; and 
 (i) any distribution permitted by Section 6.8. 

6.11. Subordinated Debt (a) Make or permit any payment on any Subordinated Debt, except (i) under the terms of the
subordination, intercreditor or other similar Contract to which such Subordinated Debt is subject and (ii) refinancings of any Subordinated Debt with any Indebtedness permitted to be incurred under Section 6.4, or
(b) amend any provision in any Contract or document relating to any Subordinated Debt that would increase the 

  
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 principal amount thereof, provide for the payment of interest applicable thereto at any time prior to the
date on which all of the Obligations have been paid in full, shorten the final maturity thereof or require any payment thereunder to be made sooner than originally scheduled, increase the interest rate applicable thereto or add or change any other
terms thereof, in each case except under the terms of the subordination, intercreditor, or other similar Contract to which such Subordinated Debt is subject, or adversely affect the subordination thereof to Obligations owed to Lender. 

6.12. Amendments or Waivers of Organizational Documents. Amend, restate, supplement or otherwise modify, or waive, any provision
of its Operating Documents in a manner that would adversely affect its ability to perform any of its agreements or obligations under any of the Loan Documents or would adversely affect any of the rights or remedies available to, or conferred upon,
Lender under any Loan Document. 
 6.13. Fiscal Year. Borrower will cause (a) each of its and its Subsidiaries’ fiscal
years to end on December 31 of each calendar year and (b) each of its and its Subsidiaries’ fiscal quarters to end on March 31, June 30, September 30 and December 31. Except to the extent necessary to comply with
the foregoing, no Credit Party shall, nor shall it permit any of its Subsidiaries to, change its fiscal year without prior written notice to Lender. 

6.14. Compliance. Become an “investment company” under the Investment Company Act of 1940, as amended, or a company
controlled by an “investment company” or undertake as one of its important activities extending credit to purchase or carry margin stock (as defined in Regulation U of the Board of Governors of the Federal Reserve System), or use the
proceeds of the Credit Extensions for that purpose; no ERISA Affiliate shall cause or suffer to exist (a) any event that could result in the imposition of a Lien on any asset of a Credit Party or a Subsidiary of a Credit Party with respect to
any Plan or Multiemployer Plan or (b) any other ERISA Event, in the case of clauses (a) and (b), that would, in the aggregate, result in liabilities which reasonably could be expected to result in a Material Adverse Change;
fail to comply with the Federal Fair Labor Standards Act or violate any other Requirements of Law, if such failure or violation, individually or together with any other such failures or violations, could reasonably be expected to have a Material
Adverse Change; or permit the occurrence of any other event with respect to any present pension, profit sharing or deferred compensation plan which, individually or together with any other such events, could reasonably be expected to result in a
Material Adverse Change. 
 6.15. Compliance with Anti-Terrorism Laws. Lender hereby notifies each Credit Party that pursuant
to the requirements of Anti-Terrorism Laws, and Lender’s policies and practices, Lender is required to obtain, verify and record certain information and documentation that identifies each Credit Party and its principals, which information
includes the name and address of each Credit Party and its principals and such other information that will allow Lender to identify such party in accordance with Anti-Terrorism Laws. No Credit Party will, nor will any Credit Party permit any of its
Subsidiaries or Affiliates to, directly or indirectly, knowingly enter into any documents or Contracts with any Person listed on the OFAC Lists. Each Credit Party shall immediately notify Lender in writing if such Credit Party or any of its
Subsidiaries has knowledge that any Credit Party or any Subsidiary or Affiliate of any Credit Party is listed on the OFAC Lists or (a) is convicted on, (b) pleads nolo contendere to, (c) is indicted on, or (d) is arraigned
and held over on charges involving money laundering or predicate crimes to money laundering. No Credit Party will, nor will any Credit Party permit any of its Subsidiaries or Affiliates to, directly or indirectly, (i) conduct any business or
engage in any transaction or dealing with any Blocked Person, including the making or receiving of any contribution of funds, goods or services to or for the benefit of any Blocked Person, (ii) deal in, or otherwise engage in any transaction
relating to, any property or interests in property blocked pursuant to Executive Order No. 13224, any similar executive order or other Anti-Terrorism Law, or (iii) engage in or conspire to engage in any transaction that evades or avoids,
or has the purpose of evading or avoiding, or attempts to violate, any of the prohibitions set forth in Executive Order No. 13224 or other Anti-Terrorism Law. 

6.16. Current Company IP Agreements and Material Contracts. Except as described on Schedule 4.11 of the Disclosure Letter with
respect to the Existing Oxford Loan Agreement, (a) waive, amend, cancel or terminate, or exercise or fail to exercise, or fail to enforce, any material rights under or relating to any of the Current Company IP Agreements or any Material
Contract, (b) default under, or take any action or fail to take any action that with the passage of time or the giving of notice or both would constitute a material breach of, or a default or event of default under, any of the Current Company
IP Agreements or any Material Contract, (c) fail to diligently monitor the performance of any counterparty to any Current Company IP Agreement or Material Contract and enforce all rights under such Contracts, in each case, which, individually
or together with any other such waivers, 

  
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 amendments, cancellations, terminations, agreements, exercises, failures, defaults or actions, could
reasonably be expected to result in a Material Adverse Change or (d) enter into any Contract pursuant to which any Consulting Royalties may become due and payable with respect to the Products that have been Commercialized on or prior to the
Tranche A Closing Date. 
 6.17. Minimum Net Sales; Minimum Consolidated EBITDA. 

(a) Permit trailing twelve-month Net Sales of Borrower and its Subsidiaries on a consolidated basis, tested at the end of each fiscal quarter
commencing with the fiscal quarter ending December 31, 2017 through the fiscal quarter ending December 31, 2018 to fall below: 
  

					
	Twelve Months Ending	  	Minimum Net Sales	 
	 December 31, 2017
	  	$	46,000,000	 
	 March 31, 2018
	  	$	46,500,000	 
	 June 30, 2018
	  	$	47,500,000	 
	 September 30, 2018
	  	$	48,500,000	 
	 December 31, 2018
	  	$	50,000,000	 

 (b) Permit both of (i) trailing twelve-month Net Sales of Borrower and its Subsidiaries on a consolidated
basis and (ii) realized trailing twelve-month Consolidated EBITDA, in each case, tested at the end of each fiscal quarter commencing with the fiscal quarter ending March 30, 2019, to fall below: 

 

													
	Twelve Months Ending	  	Minimum Net Sales	 	  	 	 	  	Trailing 12-Month	 
	 	  	 	 	  	 	 	  	Consolidated EBITDA	 
	 March 31, 2019
	  	$	52,000,000	 	  	 	or	 	  	($	5,000,000	) 
	 June 30, 2019
	  	$	53,500,000	 	  	 	or	 	  	($	3,500,000	) 
	 September 30, 2019
	  	$	54,500,000	 	  	 	or	 	  	($	2,000,000	) 
	 December 31, 2019
	  	$	56,000,000	 	  	 	or	 	  	$	0.00	 
	 March 31, 2020
	  	$	57,500,000	 	  	 	or	 	  	$	1,000,000	 
	 June 30, 2020
	  	$	58,500,000	 	  	 	or	 	  	$	2,000,000	 
	 thereafter, as applicable
	  	$	60,000,000	 	  	 	or	 	  	$	3,000,000	 

 For the avoidance of doubt, for any twelve-month period, if Borrower complies with either the applicable trailing twelve-month
Net Sales amount or the applicable trailing twelve-month Consolidated EBITDA amount set forth above, Borrower shall be deemed to have complied with this Section 6.17(b). 

(c) Notwithstanding anything to the contrary contained in Section 7 and subject to the ultimate sentence of this
Section 6.17(c), in the event that Borrower fails to comply with the covenants contained in Section 6.17(a) or (b) in respect of any applicable fiscal quarter (such covenants for such
applicable periods being the “Specified Financial Covenants”) following the test for compliance therewith on the relevant date of determination, Borrower shall notify Lender in writing of such Event of Default pursuant to
Section 5.2(g) and shall have the right within sixty (60) days after the end of such applicable fiscal quarter to issue additional shares of 

  
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 Equity Interests in exchange for cash (the “Cure Right”), in an amount equal to the product
of (i) three (3) multiplied by (ii) an amount equal to the minimum trailing twelve-month Net Sales of Borrower and its Subsidiaries on a consolidated basis required by the applicable Specified Financial Covenant less the actual trailing
twelve-month Net Sales of Borrower and its Subsidiaries on a consolidated basis (the “Cure Amount”). The cash proceeds from the exercise of the Cure Right shall immediately be contributed as equity to Borrower, and promptly upon the
receipt thereof by Borrower, Borrower shall prepay, in whole or in part, the Term Loans advanced by Lender under this Agreement; provided that (A) Borrower provides written notice to Lender of its intention to exercise the Cure Right
(the “Cure Notice”) (which may be combined with the aforementioned notice of Default and which such exercise Lender acknowledges will be conditional upon Borrower’s successful issuance of Equity Interests for cash) to prepay
the Term Loans promptly upon receipt of the cash proceeds from the exercise of the Cure Right in an amount equal to the Cure Amount and (B) such prepayment shall be (1) in the event of a prepayment in part and not in whole, inclusive of
any amounts payable pursuant to Section 2.2(e) or Section 2.2(f) (as applicable) and any other amounts payable or accrued and not yet paid under Section 2.4 and
(2) in the event of a prepayment in whole and not in part accompanied by any amounts payable pursuant to Section 2.2(e) or Section 2.2(f) (as applicable) and any other amounts payable or
accrued and not yet paid under this Agreement and the other Loan Documents. Upon delivery by Borrower to Lender of the Cure Notice and until the sixtieth (60th) day after the end of such
applicable fiscal quarter, so long as no other Event of Default has occurred and is continuing during such period, Lender shall not exercise the right to accelerate the time on which the Obligations are due and payable or stop advancing money or
extending credit for Borrower’s benefit or exercise any right to foreclose on or take possession of the Collateral under Section 8.1, in each case, solely with respect to such Event of Default having occurred under the
Specified Financial Covenants; provided, however, that, if Borrower fails to remit the Cure Amount to Lender on or prior to the sixtieth (60th) day after the end of such applicable
fiscal quarter, such Event of Default under the Specified Financial Covenants shall be deemed to have occurred as of such relevant date of determination with the same effect as though there had been no cure right with respect thereto, and Lender
shall have the right to exercise any and all of its rights and remedies under Section 8.1 or otherwise in respect thereof in its sole and absolute discretion. Upon receipt by Lender of the Cure Amount within such 60-day period, Borrower shall be deemed to have satisfied the requirements of the applicable Specified Financial Covenant for the applicable fiscal quarter as of the relevant date of determination with the same
effect as though there had been no failure to comply therewith at such date, and the applicable Event of Default under the Specified Financial Covenants that had occurred shall be deemed cured without any further action of Borrower or Lender for all
purposes under the Loan Documents. Notwithstanding the foregoing, Borrower shall have no further right to exercise the Cure Right after it has exercised the Cure Right in respect of any two (2) fiscal quarters. 

7. EVENTS OF DEFAULT 

Any one of the following shall constitute an event of default (an “Event of Default”) under this Agreement: 

7.1. Payment Default. Any Credit Party fails to (a) make any payment of any principal of any Term Loan when and as the same
shall become due and payable, whether at the due date thereof (including pursuant to Section 2.2(c)) or at a date fixed for prepayment thereof (whether voluntary or mandatory) or by acceleration thereof or otherwise,
(b) make any payment of interest or premium pursuant to Section 2.2, including any applicable Makewhole Amount or Prepayment Premium when and as the same shall become due and payable or (c) pay any other
Obligations within three (3) Business Days after such Obligations are due and payable (which such three (3) Business Day cure period shall not apply to payments due on the Term Loan Maturity Date or the date of acceleration pursuant to
Section 8.1(a) hereof). A failure to pay any other Obligations pursuant to the foregoing clause (c) prior to the end of such three (3) Business Day period shall not constitute an Event of Default. 

7.2. Covenant Default. 

(a) The Credit Parties: (i) fail or neglect to perform any obligation in Sections 5.4, 5.6, 5.10 or 5.15; (ii)
fail or neglect to perform any obligation in Section 5.12, and as to any default under Section 5.12, have failed to cure such default within thirty (30) days of the first Business Day on which
Borrower and its Subsidiaries fail to have consolidated Liquidity of at least Five Million Dollars ($5,000,000.00); or (iii) violate any covenant in Section 6; or 

  
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 (b) The Credit Parties fail or neglect to perform, keep, or observe any other term,
provision, condition, covenant or agreement contained in this Agreement or any other Loan Document and, as to any default (other than those specified elsewhere in this Section 7) under such other term, provision, condition,
covenant or agreement that can be cured, have failed to cure the default within thirty (30) days after the occurrence thereof (but no Credit Extensions shall be made during such thirty (30) day cure period). Cure periods provided under
this Section 7.2(b) shall not apply to any of the covenants referenced in clause (a) above. 

7.3. Material Adverse Change A Material Adverse Change occurs. 

7.4. Attachment; Levy; Restraint on Business. 

(a) (i) The service of process seeking to attach, by trustee or similar process, any funds of any Credit Party or of any entity under the
control of any Credit Party in excess of $25,000 on deposit or otherwise maintained with Lender or any of Lender’s Affiliates or (ii) a notice of lien or levy is filed against any assets of any Credit Party or any entity under the control
of any Credit Party by any Governmental Authority, and the same under clauses (i) and (ii) hereof are not, within twenty (20) days after the occurrence thereof, discharged or stayed (whether through the posting of a bond or
otherwise); provided, however, that no Credit Extensions shall be made during any such twenty (20) day period; or 

(b) (i) Any material portion of any Credit Party’s assets is attached, seized, levied on, or comes into possession of a trustee or
receiver, or (ii) any court order enjoins, restrains, or prevents any Credit Party from conducting any material part of its business. 

7.5. Insolvency. 

(a) An involuntary proceeding shall be commenced or an involuntary petition shall be filed in a court of competent jurisdiction seeking:
(i) relief in respect of any Credit Party or any of its Subsidiaries, or of a substantial part of the properties or assets of any Credit Party or any of its Subsidiaries, under Title 11 of the United States Code, as now constituted or hereafter
amended, or any other federal, state or foreign bankruptcy, insolvency, receivership or similar law; (ii) the appointment of an examiner, receiver, trustee, custodian, sequestrator, conservator or similar official for any Credit Party or any of
its Subsidiaries or for a substantial part of the properties or assets of any Credit Party or any of its Subsidiaries; or (iii) the winding-up or liquidation of any Credit Party or any of its
Subsidiaries, and such proceeding or petition shall continue undismissed for sixty (60) days or an order or decree approving or ordering any of the foregoing shall be entered; 

(b) Any Credit Party or any of its Subsidiaries shall: (i) voluntarily commence any proceeding or file any petition seeking relief under
Title 11 of the United States Code, as now constituted or hereafter amended, or any other federal, state or foreign bankruptcy, insolvency, receivership or similar law; (ii) consent to the institution of, or fail to contest in a timely and
appropriate manner, any proceeding or the filing of any petition described in clause (a) above; (iii) apply for or consent to the appointment of a receiver, trustee, custodian, sequestrator, conservator or similar official for any Credit
Party or any of its Subsidiaries or for a substantial part of the properties or assets of any Credit Party or any of its Subsidiaries; (iv) file an answer admitting the material allegations of a petition filed against it in any such proceeding;
(v) make a general assignment for the benefit of creditors; (vi) become unable, admit in writing its inability or fail generally to pay its debts as they become due; (vii) take any action for the purpose of effecting any of the
foregoing; or (viii) wind up or liquidate (except as otherwise expressly permitted hereunder); or 
 (c) Borrower otherwise fails to be
Solvent, Borrower and its Subsidiaries that are Credit Parties, on a consolidated basis, otherwise fail to be Solvent, or Borrower and its Subsidiaries, on a consolidated basis, otherwise fail to be Solvent. 

7.6. Other Agreements. There is, under any Contract to which a Credit Party or any of its Subsidiaries is a party with a third
party or parties, (a) any breach thereof or default thereunder resulting in a right by such third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in an amount in excess of $ 500,000 individually, or in
excess of $1,000,000 when aggregated with all other breaches and defaults by any of the Credit Parties or their respective Subsidiaries under Contracts with a third party or parties or (b) any default or breach by any Credit Party or any of its
Subsidiaries, the effect of which, individually or together with any other such defaults or breaches, results in a Material Adverse Change. 

  
 40 

 7.7. Judgments. One or more judgments, orders, or decrees for the payment of money in
an amount in excess of $1,000,000 individually, or in excess of $3,000,000 when aggregated with all other judgments, orders, or decrees for the payment of money (but excluding any judgments, orders, or decrees for the payment of money that
are covered by independent third-party insurance as to which liability has been accepted by such insurance carrier), shall be rendered against any Credit Party or any of its Subsidiaries and shall remain unsatisfied, unvacated or unstayed for a
period of twenty (20) days after the entry thereof; provided, however, that no Credit Extensions shall be made prior to the satisfaction, vacation or stay of such judgment, order or decree. 

7.8. Misrepresentations. Any Credit Party or any Person acting for any Credit Party makes or is deemed to make any
representation, warranty, or other statement now or later in this Agreement, any other Loan Document or in any writing delivered to Lender or to induce Lender to enter this Agreement or any other Loan Document, and such representation, warranty, or
other statement is incorrect in any material respect (or, to the extent any such representation, warranty or other statement is qualified by materiality or Material Adverse Change, in any respect) when made or deemed to be made. 

7.9. Loan Documents; Collateral. 

(a) Any material provision of any Loan Document shall for any reason (other than solely due to action or inaction of Lender) cease to be valid
and binding on or enforceable against any Credit Party (or any Subsidiary of a Credit Party party thereto) or any Credit Party (or any such Subsidiary) shall so state in writing or bring an action to limit its obligations or liabilities thereunder.

 (b) One or more Collateral Documents governing Collateral with an aggregate value, individually with respect to any one such Collateral
Document or together with any other Collateral governed by any other such Collateral Documents, in excess of $500,000 (which shall be reasonably determined by a Responsible Officer of Borrower in good faith and based upon reasonable assumptions)
shall for any reason (other than pursuant to the terms thereof) cease to create a valid security interest in the Collateral purported to be covered thereby or such security interest shall for any reason cease to be a perfected and first priority
security interest in the Collateral subject thereto subject only to Permitted Liens, except (i) to the extent that any such loss of perfection or priority results from the limitations of foreign laws, rules and regulations as they apply to
pledges of Equity Interests in Foreign Subsidiaries or the application thereof, (ii) for the failure of Lender to maintain possession of certificates actually delivered to it representing securities pledged under the Security Agreement or to
file Code financing statements (including continuation statements) or to take such other actions as Lender is required to take in order to perfect and maintain a perfected first priority security interest in the Collateral subject to Permitted Liens
and (iii) to the extent that such loss is covered by a lender’s title insurance policy as to which liability has been accepted by the title insurer. 

7.10. Subordinated Debt. Any Contract providing for the subordination of any Subordinated Debt shall for any reason be revoked
or invalidated or otherwise cease to be in full force and effect, any Credit Party or any creditor party thereto shall be in breach thereof, in default thereunder or contest in any manner the validity or enforceability thereof or deny that it has
any further liability or obligation thereunder, or the Obligations shall for any reason be subordinated or shall not have the priority contemplated by this Agreement and the other Loan Documents. 

7.11. Change in Control. A Change in Control occurs. 

7.12. ERISA Event. An ERISA Event occurs that, individually or together with any other ERISA Events, results or could reasonably
be expected to result in a Material Adverse Change or a material liability of Borrower or any of its Subsidiaries or any of their respective ERISA Affiliates or the imposition of a Lien on a material portion of the properties and assets of Borrower
and its Subsidiaries, taken as a whole. 

  
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 8. RIGHTS AND REMEDIES UPON AN EVENT OF DEFAULT 

8.1. Rights and Remedies. Subject to Section 6.17(c) solely with respect to a violation of the Specified Financial
Covenants, while an Event of Default occurs and continues, Lender may, without notice or demand: 
 (a) declare all Obligations (including,
for the avoidance of doubt, any applicable Makewhole Amount or Prepayment Premium) immediately due and payable (but if an Event of Default described in Section 7.5 occurs all Obligations, including any applicable Makewhole
Amount or Prepayment Premium, are automatically and immediately due and payable without any action by Lender), whereupon all Obligations for principal, interest, premium or otherwise (including, for the avoidance of doubt, any applicable Makewhole
Amount or Prepayment Premium) shall become due and payable by Borrower without presentment, demand, protest or other notice of any kind, which are all expressly waived by the Credit Parties hereby; 

(b) stop advancing money or extending credit for Borrower’s benefit under this Agreement; 

(c) settle or adjust disputes and claims directly with Account Debtors for amounts on terms and in any order that Lender considers advisable,
notify any Person owing Borrower money of Lender’s security interest in such funds, and verify the amount of such account; 
 (d) make
any payments and do any acts it considers necessary or reasonable to protect the Collateral or its security interest in the Collateral. Borrower shall assemble the Collateral if Lender requests and make it available as Lender designates. Lender may
enter premises where the Collateral is located, take and maintain possession of any part of the Collateral, and pay, purchase, contest, or compromise any Lien which appears to be prior or superior to its security interest and pay all expenses
incurred. Borrower grants Lender a license to enter and occupy any of its premises, without charge, to exercise any of Lender’s rights or remedies; 

(e) apply to the Obligations (i) any balances and deposits of Borrower it holds, or (ii) any amount held by Lender owing to or for
the credit or the account of Borrower; 
 (f) ship, reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise for sale,
and sell the Collateral. With respect to any and all Intellectual Property owned by any Credit Party and, to the extent such Credit Party is permitted to do so, with respect to any and all Intellectual Property licensed by a third party to any
Credit Party, each Credit Party hereby grants to Lender, as of the Tranche A Closing Date, a non-exclusive, royalty-free license or other right to use, without charge, such Credit Party’s labels, Patents,
Copyrights, mask works, rights of use of any name, trade secrets, trade names, Trademarks (other than any “intent-to-use” Trademarks until the earlier of the
filing of a statement of use with respect thereto or the issuance of a registration therefor) and advertising matter, or any similar properties or assets as it pertains to the Collateral, in completing production of, advertising for sale, and
selling any Collateral and, in connection with Lender’s exercise of its rights under this Section 8.1, such Credit Party’s rights under all licenses and all franchise Contracts inure to Lender’s benefit; 

(g) place a “hold” on any account maintained with Lender or deliver a notice of exclusive control, any entitlement order, or other
directions or instructions pursuant to any Control Agreement or similar Contracts providing control of any Collateral; 
 (h) demand and
receive possession of Borrower’s Books; and 
 (i) exercise all rights and remedies available to Lender under the Collateral Documents
or any other Loan Documents or at law or equity, including all remedies provided under the Code (including disposal of the Collateral pursuant to the terms thereof). 

Lender agrees that, in connection with any foreclosure or other exercise of rights under this Agreement or any other Loan Document with
respect to the Intellectual Property, the rights of the licensees under the Permitted Licenses will not be terminated, limited or otherwise adversely affected so long as no default exists under the Permitted License in a way that would permit the
licensor to terminate such Permitted License (commonly termed a non-disturbance). 

  
 42 

 8.2. Power of Attorney. Borrower hereby irrevocably appoints Lender as its lawful attorney-in-fact, exercisable only upon the occurrence and during the continuance of an Event of Default, to: (a) endorse Borrower’s name on any checks or
other forms of payment or security; (b) sign Borrower’s name on any invoice or bill of lading for any Account or drafts against Account Debtors; (c) settle and adjust disputes and claims about the Accounts directly with Account
Debtors, for amounts and on terms Lender determines reasonable; (d) make, settle, and adjust all claims under Borrower’s insurance policies; (e) pay, contest or settle any Lien, charge, encumbrance, security interest, and adverse
claim in or to the Collateral, or any judgment based thereon, or otherwise take any action to terminate or discharge the same; and (f) transfer the Collateral into the name of Lender or a third party as the Code permits. Borrower hereby
appoints Lender as its lawful attorney-in-fact to file or record any documents necessary to perfect or continue the perfection of Lender’s security interest in the
Collateral regardless of whether an Event of Default has occurred until all Obligations (other than inchoate indemnity obligations) have been satisfied in full and Lender is not under any further obligation to make any Credit Extensions hereunder.
Lender’s foregoing appointment as Borrower’s attorney in fact, and all of Lender’s rights and powers, coupled with an interest, are irrevocable until all Obligations (other than inchoate indemnity obligations) have been fully repaid
and performed and Lender’s obligation to provide any Credit Extensions hereunder terminates. 
 8.3. [Reserved.] 

8.4. Application of Payments and Proceeds upon Default. If an Event of Default has occurred and is continuing, Lender may apply
any funds in its possession, whether from Borrower account balances, payments, proceeds realized as the result of any collection of Accounts or other disposition of the Collateral, or otherwise, to the Obligations in such order as Lender shall
determine in its sole discretion. After any such application, any surplus shall be paid to Borrower or other Persons legally entitled thereto; Borrower shall remain liable to Lender for any deficiency. If Lender directly or indirectly enters into a
deferred payment or other credit transaction with any purchaser at any sale of Collateral, Lender shall have the option, exercisable at any time, of either reducing the Obligations by the principal amount of the purchase price or deferring the
reduction of the Obligations until the actual receipt by Lender of cash therefor. 
 8.5. Lender’s Liability for Collateral. So
long as Lender complies with Requirements of Law regarding the safekeeping of the Collateral in the possession or under the control of Lender, Lender shall not be liable or responsible for: (a) the safekeeping of the Collateral;
(b) any loss or damage to the Collateral; or (c) any act or default of any carrier, landlord, warehouseman, bailee, or other Person. In no event shall Lender have any liability for any diminution in the value of the Collateral for any
reason. Borrower bears all risk of loss, damage or destruction of the Collateral. 
 8.6. No Waiver; Remedies Cumulative.
Lender’s failure, at any time or times, to require strict performance by Borrower of any provision of this Agreement or any other Loan Document shall not waive, affect, or diminish any right of Lender thereafter to demand strict
performance and compliance herewith or therewith. No waiver hereunder shall be effective unless signed by the party granting the waiver and then is only effective for the specific instance and purpose for which it is given. Lender’s rights and
remedies under this Agreement and the other Loan Documents are cumulative. Lender has all rights and remedies provided under the Code, by law, or in equity. Lender’s exercise of one right or remedy is not an election and shall not preclude
Lender from exercising any other remedy under this Agreement or other remedy available at law or in equity, and Lender’s waiver of any Event of Default is not a continuing waiver. Lender’s delay in exercising any remedy is not a waiver,
election, or acquiescence. 
 8.7. Demand Waiver; Makewhole Amount; Prepayment Premium. Borrower waives demand, notice of
default or dishonor, notice of payment and nonpayment, notice of any default, nonpayment at maturity, release, compromise, settlement, extension, or renewal of accounts, documents, instruments, chattel paper, and guarantees held by Lender on which
Borrower is liable. Borrower acknowledges and agrees that if the maturity of all Obligations shall be accelerated pursuant to Section 8.1(a) by reason of the occurrence of an Event of Default, any applicable Makewhole
Amount or Prepayment Premium, shall become due and payable by Borrower upon such acceleration, whether such acceleration is automatic or is effected by Lender’s declaration thereof, as provided in Section 8.1(a), and
Borrower shall pay any applicable Makewhole Amount or Prepayment Premium as compensation to Lender for the loss of its investment opportunity and not as a penalty, and Borrower waives any right to object thereto in any voluntary or involuntary
bankruptcy, insolvency or similar proceeding or otherwise. 

  
 43 

 9. NOTICES 

All statements, certificates, notices, reports, consents, requests, approvals, demands, or other communication by any party to this Agreement
or any other Loan Document must be in writing and shall be deemed to have been validly served, given, or delivered: (a) upon the earlier of actual receipt and three (3) Business Days after deposit in the U.S. mail, first class, registered
or certified mail return receipt requested, with proper postage prepaid; (b) upon transmission, when sent by electronic mail or facsimile transmission; (c) one (1) Business Day after deposit with a reputable overnight courier with all
charges prepaid; or (d) when delivered, if hand-delivered by messenger, all of which shall be addressed to the party to be notified and sent to the address, facsimile number, or email address (if any) indicated below. Lender or any Credit Party
may change its mailing or electronic mail address or facsimile number by giving all other parties hereto written notice thereof in accordance with the terms of this Section 9. 

 

			
	 If to Borrower or
	  	SI-BONE, Inc.
	 other Credit Party:
	  	3055 Olin Avenue, Suite 2200
		  	San Jose, CA 95128
		  	Attn: Jeffrey Dunn, President and Chief Executive Officer
		  	         Laura Francis, Chief Financial Officer
		  	Telephone: +1 (408) 207-0700
		  	Facsimile: 408.557.8312
		  	Email: JDunn@si-bone.com; lfrancis@si-bone.com
	
	 with a copy to (which shall not constitute notice) to:

		
		  	Cooley LLP
		  	101 California Street, 5th Floor
		  	San Francisco, CA 94111-5800
		  	Attn: Gian-Michele a Marca
		  	Telephone: +1 (415) 693-2148
		  	Facsimile: +1 (415) 693-2222
		  	Email: gmamarca@cooley.com
		
	 If to Lender:
	  	BioPharma Credit Investments IV Sub LP
		  	c/o Walkers Corporate Limited
		  	Cayman Corporate Centre
		  	27 Hospital Road
		  	George Town, Grand Cayman KY1-9008
		  	Cayman Islands
		  	Attention: Pedro Gonzalez de Cosio
		  	Telephone: +1 (212) 883-2296
		  	Facsimile: +1 (917) 210-4048
		  	Email: pg@PharmakonAdvisors.com
	
	 with copies (which shall not constitute notice) to:

		
		  	Pharmakon Advisors LP
		  	110 East 59th Street, #3300
		  	New York, NY 10022
		  	Attn: Pedro Gonzalez de Cosio
		  	Phone: +1 (212) 883-2296
		  	Fax: +1 (917) 210-4048
		  	Email: pg@PharmakonAdvisors.com

  
 44 

			
		
		  	and
		
		  	 Akin Gump Strauss Hauer & Feld LLP

		  	 One Bryant Park

		  	 New York, NY 10036-6745

		  	 Attn: Geoffrey E. Secol

		  	 Phone: (212) 872-8081

		  	 Fax: (212) 872-1002

		  	 Email: gsecol@akingump.com

 10. CHOICE OF LAW, VENUE AND JURY TRIAL WAIVER 

THIS AGREEMENT AND THE OTHER LOAN DOCUMENTS SHALL EACH BE GOVERNED BY, AND CONSTRUED AND INTERPRETED IN ACCORDANCE WITH THE LAWS OF THE STATE
OF NEW YORK, WITHOUT REGARD TO ANY PRINCIPLES OF CONFLICTS OF LAW THAT COULD REQUIRE THE APPLICATION OF THE LAW OF ANY OTHER JURISDICTION. Each of the Credit Parties and Lender submit to the exclusive jurisdiction of the courts of the State of New
York sitting in New York County, and of the United States District Court of the Southern District of New York, and any appellate court from any thereof, and agrees that all claims in respect of any such action, litigation or proceeding may be heard
and determined in such New York State court or, to the fullest extent permitted by Requirements of Law, in such Federal court; provided, however, that nothing in this Agreement shall be deemed to operate to preclude Lender from
bringing suit or taking other legal action in any other jurisdiction to realize on the Collateral or any other security for the Obligations, or to enforce a judgment or other court order in favor of Lender. Each Credit Party expressly submits and
consents in advance to such jurisdiction in any action or suit commenced in any such court, and each Credit Party hereby waives any objection that it may have based upon lack of personal jurisdiction, improper venue, or forum non conveniens
and hereby consents to the granting of such legal or equitable relief as is deemed appropriate by such court. Each Credit Party hereby waives personal service of the summons, complaints, and other process issued in such action or suit and agrees
that service of such summons, complaints, and other process may be made by registered or certified mail addressed to such Credit Party at the address set forth in (or otherwise provided in accordance with the terms of)
Section 9 of this Agreement and that service so made shall be deemed completed upon the earlier to occur of such Credit Party’s actual receipt thereof or three (3) Business Days after deposit in the U.S. mails,
proper postage prepaid. 
 TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, EACH OF THE CREDIT PARTIES AND LENDER WAIVE ITS RIGHT TO A
JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION ARISING OUT OF OR BASED UPON THIS AGREEMENT, THE OTHER LOAN DOCUMENTS OR ANY TRANSACTION CONTEMPLATED HEREBY OR THEREBY, INCLUDING CONTRACT, TORT, BREACH OF DUTY AND ALL OTHER CLAIMS. EACH OF THE CREDIT
PARTIES AND LENDER (A) CERTIFIES THAT NO OTHER PARTY HERETO (AND NO AFFILIATE OF ANY OTHER PARTY AND NO DIRECTOR, OFFICER, EMPLOYEE, AGENT, TRUSTEE, REPRESENTATIVE, ATTORNEY, ACCOUNTANT, ADVISOR OR CONSULTANT OF ANY OTHER PARTY OR AFFILIATE)
HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PARTY WOULD NOT, IN THE EVENT OF LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER, (B) ACKNOWLEDGES THAT THE FOREGOING MUTUAL WAIVERS AND CERTIFICATIONS ARE A MATERIAL INDUCEMENT FOR IT
AND THE OTHER PARTIES HERETO TO ENTER INTO THIS AGREEMENT AND (C) HAS REVIEWED THIS WAIVER WITH ITS COUNSEL. 
 11. GENERAL
PROVISIONS 
 11.1. Successors and Assigns. This Agreement binds and is for the benefit of the parties hereto and their
respective successors and permitted assigns. No Credit Party may sell, transfer, assign or pledge this Agreement or any other Loan Document or any of its rights or obligations hereunder or thereunder without Lender’s prior written consent.
Lender may sell, transfer, assign or pledge this Agreement or any other Loan Document or any of its rights or obligations hereunder or thereunder to any third party (other than any Vulture Fund or Competitor) without Borrower’s consent,
including to grant or sell a participation in all or any part of, or any interest in, Lender’s obligations, rights or benefits under this Agreement and the other Loan Documents (any such sale, transfer, assignment, pledge or grant or sale of a
participation, a “Lender Transfer”). Lender shall record such 

  
 45 

 Lender Transfer in the “book entry system” maintained pursuant to
Section 2.8. Any attempted sale, transfer, assignment or pledge of this Agreement or any other Loan Document or any rights or obligations hereunder or thereunder in violation of this Section 11.1
shall be null and void ab initio and of no effect. 
 11.2. Indemnification; Costs and Expenses. 

(a) Borrower agrees to indemnify and hold harmless each of Lender and its Affiliates (and its or their successors and assigns) and each of its
and their respective managers, members, equityholders, partners, controlling Persons, directors, officers, employees, agents or sub-agents, advisors and affiliates (each such Person, an “Indemnified
Person”) from and against any and all Indemnified Liabilities; provided that (i) Borrower shall not have any obligation to any Indemnified Person hereunder with respect to any Indemnified Liabilities to the extent such
Indemnified Liabilities arise from the bad faith, gross negligence or willful misconduct of such Indemnified Person (or its Affiliates or controlling Persons or its or their respective directors, officers, managers, partners, members, equityholders,
agents, sub-agents or advisors), in each case, as determined by a final, non-appealable judgment of a court of competent jurisdiction, (ii) Borrower shall not have
any obligation to any Indemnified Person hereunder with respect to any Indemnified Liabilities to the extent such Indemnified Liabilities arise from a material breach of any obligation of Lender hereunder, and (iii) Borrower shall not have any
obligation to any Indemnified Person hereunder with respect to any Indemnified Liabilities to the extent such Indemnified Liabilities arise from any claim by one Indemnified Person against another Indemnified Person that does not relate to any act
or omission of any Credit Party or any of its Subsidiaries, and (iv) Borrower shall not be liable for any settlement of any claim or proceeding effected by any Indemnified Person without the prior written consent of such Credit Party (which
consent shall not be unreasonably conditioned, withheld or delayed), but if settled with such consent or if there shall be a final judgment against an Indemnified Person, Borrower shall indemnify and hold harmless such Indemnified Person from and
against any loss or liability by reason of such settlement or judgment in the manner set forth in this Agreement. 
 (b) To the extent
permitted by Requirements of Law, no Credit Party shall assert, and each Credit Party hereby waives, any claim against Lender and its Affiliates (and its or their successors and assigns), and each manager, member, equityholder, partner, controlling
Person, director, officer, employee, agent or sub-agent, advisor and affiliate thereof, on any theory of liability, for special, indirect, consequential or punitive damages (as opposed to direct or actual
damages) (whether or not the claim therefor is based on contract, tort or duty imposed by any applicable legal requirement) arising out of, in connection with, arising out of, as a result of, or in any way related to, this Agreement or any Loan
Document or any Contract contemplated hereby or thereby or referred to herein or therein, the transactions contemplated hereby or thereby, any Term Loan or the use of the proceeds thereof or any act or omission or event occurring in connection
therewith, and each Credit Party hereby waives, releases and agrees not to sue upon any such claim or any such damages, whether or not accrued and whether or not known or suspected to exist in its favor. 

(c) Any action taken by any Credit Party or any of its Subsidiaries under or with respect to any Loan Document, even if required under any Loan
Document or at the request of Lender, shall be at the expense of such Credit Party or Subsidiary, and no Secured Party shall be required under any Loan Document to reimburse any Credit Party or any Subsidiary of any Credit Party therefor except as
expressly provided therein. In addition, Borrower agrees to pay or reimburse upon demand (i) Lender (and its successors and assigns) for all reasonable
out-of-pocket costs and expenses incurred by it or any of its Affiliates or any of its or their respective directors, officers, employees, agents and sub-agents, in connection with the investigation, development, preparation, negotiation, syndication, execution, interpretation or administration of, any modification of any term of or termination of, any Loan
Document, any commitment or proposal letter therefor, any other document prepared in connection therewith or the consummation and administration of any transaction contemplated therein, (ii) Lender (and its successors and assigns) for all
reasonable costs and expenses incurred by it or any of its Affiliates or any of its or their respective directors, officers, employees, agents and sub-agents in connection with internal audit reviews and
Collateral audits and (iii) Lender (and its successors and assigns) and any of its Affiliates or any of its or their respective directors, officers, employees, agents and sub-agents for all costs and
expenses incurred in connection with (A) any refinancing or restructuring of the credit arrangements provided hereunder in the nature of a “work-out,” (B) the enforcement or preservation of any
right or remedy under any Loan Document, any Obligation, with respect to the Collateral or any other related right or remedy or (C) the commencement, defense, conduct of, intervention in, or the taking of any other action with respect to, any
proceeding (including any bankruptcy or insolvency proceeding) related to any Credit Party, any Subsidiary of any Credit Party, Loan Document or Obligation (or the response to and preparation for any subpoena or request for document production
relating thereto), including Lender Expenses. 

  
 46 

 11.3. Severability of Provisions. In case any provision in or obligation hereunder or
under any other Loan Document shall be invalid, illegal or unenforceable in any jurisdiction, the validity, legality and enforceability of the remaining provisions or obligations, or of such provision or obligation in any other jurisdiction,
shall not in any way be affected or impaired thereby. 
 11.4. Correction of Loan Documents. Lender may correct patent errors and
fill in any blanks in the Loan Documents consistent with the agreement of the parties hereto so long as Lender provides Credit Parties with written notice of such correction and allows Credit Parties at least ten (10) days to object to
such correction. In the event of such objection, such correction shall not be made except by an amendment signed by Lender and Credit Parties. 

11.5. Amendments; Waivers; Integration. (a) No amendment or modification of any provision of this Agreement or any other
Loan Document, or waiver, discharge or termination of any obligation hereunder or thereunder, no approval or consent hereunder or thereunder (including any consent by Borrower to any departure herefrom or therefrom), shall in any event be effective
unless the same shall be in writing and signed by Borrower and Lender. Any waiver, approval or consent granted shall be limited to the specific circumstance expressly described in it, and shall not apply to any subsequent or other circumstance,
whether similar or dissimilar, or give rise to, or evidence, any obligation or commitment to grant any further waiver, approval or consent. 

(b) This Agreement and the other Loan Documents represent the entire agreement about this subject matter and supersede prior negotiations or
Contracts. All prior Contracts, understandings, representations, warranties, and negotiations between the parties hereto about the subject matter of this Agreement and the other Loan Documents merge into this Agreement and the other Loan Documents.

 11.6. Counterparts. This Agreement may be executed in any number of counterparts and by different parties on separate
counterparts, each of which, when executed and delivered, is an original, and all taken together, constitute one Agreement. 
 11.7.
Survival. All covenants, representations and warranties made in this Agreement continue in full force until this Agreement has terminated pursuant to its terms and all Obligations (other than inchoate indemnity obligations and any other
obligations which, by their terms, are to survive the termination of this Agreement) have been paid in full and satisfied. The obligation of Borrower in Section 11.2 to indemnify Lender (including the obligations in
Section 11.2(c)) shall survive until the statute of limitations with respect to such claim or cause of action shall have run. 

11.8. Confidentiality. Any information regarding Credit Parties and their Subsidiaries and their businesses provided to Lender
by or on behalf of any Credit Party pursuant to this Agreement shall be deemed “Confidential Information”; provided, however, that Confidential Information does not include information that is either: (i) in the
public domain or in Lender’s or any of its Affiliate’s possession when disclosed to Lender or any of its Affiliates, or becomes part of the public domain after disclosure to Lender or any of its Affiliates other than as a result of a
breach by Lender or any of its Affiliates of the obligations under this Section 11.8; or (ii) disclosed to Lender or any of its Affiliates by a third party if Lender or any of its Affiliates do not know that the third
party is prohibited from disclosing the information. Lender shall not disclose any Confidential Information to a third party or use Confidential Information for any purpose other than the exercise of Lender’s rights and the performance of
Lender’s obligations under the Loan Documents. The foregoing in this Section 11.8 notwithstanding, Lender may disclose Confidential Information: (a) to any of Lender’s Subsidiaries or Affiliates; (b) to
prospective transferees or purchasers of any interest in the Credit Extensions; (c) as required by law, regulation, subpoena, or other order; provided that Lender shall promptly notify the applicable Credit Party in writing, if not
prohibited by Requirements of Law, and provide such Credit Party reasonable time to oppose such process; (d) to the extent requested by regulators having jurisdiction over Lender or as required in connection with Lender’s examination or
audit pursuant to Section 5.9 hereof; (e) as Lender considers appropriate in its reasonable, good faith discretion in exercising remedies under the Loan Documents; and (f) to third-party service providers of
Lender; provided, however, that the third parties to which Confidential Information is disclosed pursuant to clauses (a), (b), (e) and (f) are bound by obligations of confidentiality and non-use that are no less restrictive than those contained herein. 

  
 47 

 The provisions of the immediately preceding paragraph shall survive the termination of this Agreement. 

11.9. Attorneys’ Fees, Costs and Expenses. In any action or proceeding between any Credit Party and Lender arising out of
or relating to the Loan Documents, the prevailing party shall be entitled to recover its reasonable attorneys’ fees and other costs and expenses incurred, in addition to any other relief to which it may be entitled. 

11.10. Right of Set-Off. In addition to any rights now or hereafter granted under Requirements
of Law and not by way of limitation of any such rights, upon the occurrence of an Event of Default and at any time thereafter during the continuance of any Event of Default, Lender is hereby authorized by each Credit Party at any time or from
time to time, without notice to any Credit Party or to any other Person, any such notice being hereby expressly waived, to set off and to appropriate and to apply any and all deposits (general or special, including Indebtedness evidenced by
certificates of deposit, whether matured or unmatured, but not including trust accounts) and any other Indebtedness at any time held or owing by Lender to or for the credit or the account of any Credit Party against and on account of the obligations
and liabilities of any Credit Party to Lender hereunder and under the other Loan Documents, including all claims of any nature or description arising out of or connected hereto or with any other Loan Document, irrespective of whether or not
(a) Lender shall have made any demand hereunder or (b) the principal of or the interest on the Term Loans or any other amounts due hereunder shall have become due and payable pursuant to Section 2 and although
such obligations and liabilities, or any of them, may be contingent or unmatured. 
 11.11. Marshalling; Payments Set Aside. Lender
shall not be under any obligation to marshal any assets in favor of any Credit Party or any other Person or against or in payment of any or all of the Obligations. To the extent that any Credit Party makes a payment or payments to Lender, or
Lender enforces any Liens or exercises its rights of setoff, and such payment or payments or the proceeds of such enforcement or setoff or any part thereof are subsequently invalidated, declared to be fraudulent or preferential, set aside or
required to be repaid to a trustee, receiver or any other party under any bankruptcy law, any other state or federal law, common law or any equitable cause, then, to the extent of such recovery, the obligation or part thereof originally intended to
be satisfied, and all Liens, rights and remedies therefor or related thereto, shall be revived and continued in full force and effect as if such payment or payments had not been made or such enforcement or setoff had not occurred. 

11.12. Electronic Execution of Documents. The words “execution,” “signed,” “signature” and words of
like import in any Loan Document shall be deemed to include electronic signatures or the keeping of records in electronic form, each of which shall be of the same legal effect, validity and enforceability as a manually executed signature or the
use of a paper-based recordkeeping systems, as the case may be, to the extent and as provided for in any Requirements of Law, including any state law based on the Uniform Electronic Transactions Act. 

11.13. Captions. Section headings herein are included herein for convenience of reference only and shall not constitute a part
hereof for any other purpose or be given any substantive effect. 
 11.14. Construction of Agreement. The parties hereto mutually
acknowledge that they and their attorneys have participated in the preparation and negotiation of this Agreement. In cases of uncertainty this Agreement shall be construed without regard to which of the parties hereto caused the uncertainty
to exist. 
 11.15. Third Parties. Nothing in this Agreement, whether express or implied, is intended to: (a) confer any
benefits, rights or remedies under or by reason of this Agreement on any Persons other than the express parties to it and their respective successors and permitted assigns; (b) relieve or discharge the obligation or liability of any Person not
an express party to this Agreement; or (c) give any Person not an express party to this Agreement any right of subrogation or action against any party to this Agreement. 

11.16. No Fiduciary Duty. Lender may have economic interests that conflict with those of the Credit Parties. Each Credit Party
agrees that nothing in the Loan Documents or otherwise will be deemed to create an advisory, fiduciary or agency relationship or fiduciary or other implied duty between Lender, on the one hand, and 

  
 48 

 such Credit Party, its Subsidiaries, and any of their respective stockholders or affiliates, on the other
hand. Each Credit Party acknowledges and agrees that (i) the transactions contemplated by the Loan Documents are arm’s-length commercial transactions between Lender, on the one hand, and such Credit
Party, its Subsidiaries and their respective affiliates, on the other, (ii) in connection therewith and with the process leading to such transaction, Lender is acting solely as a principal and not the agent or fiduciary of such Credit Party,
its Subsidiaries or their respective affiliates, management, stockholders, creditors or any other person, (iii) Lender has not assumed an advisory or fiduciary responsibility in favor of any Credit Party, its Subsidiaries or their respective
affiliates with respect to the transactions contemplated hereby or the process leading thereto (irrespective of whether Lender or any of its affiliates has advised or is currently advising such Credit Party, its Subsidiaries or their respective
affiliates on other matters) or any other obligation to such Credit Party, its Subsidiaries or their respective affiliates except the obligations expressly set forth in the Loan Documents and (iv) each Credit Party, its Subsidiaries and their
respective affiliates have consulted their own legal and financial advisors to the extent each deemed appropriate. Each Credit Party further acknowledges and agrees that it is responsible for making its own independent judgment with respect to such
transactions and the process leading thereto. Each Credit Party agrees that it will not claim that Lender has rendered advisory services of any nature or respect, or owes a fiduciary or similar duty to such Credit Party, its Subsidiaries or their
respective affiliates in connection with such transaction or the process leading thereto. 
 12. LENDER AGREEMENTS 

12.1. Intercreditor Agreement. In connection with the incurrence by Borrower of any Permitted Indebtedness pursuant to clause
(e) of the definition of Permitted Indebtedness, Lender hereby agrees that it will enter into a subordination, intercreditor or other similar Contract with the lender in respect of such Permitted Indebtedness and Borrower, which shall
provide that the security interests and Liens of such lender in and on Inventory, accounts receivable, cash, supporting obligations and all proceeds of the foregoing to secure the obligations under such loan facility shall be senior in rank, order
of priority and enforcement to the security interests and Liens of Lender in any such assets to secure the Obligations at all times until all of the obligations under such facility have been paid, performed or discharged in full and Borrower has no
further right to obtain any extensions of credit thereunder, in form and substance reasonably satisfactory to Lender and such lender. 

12.2. Non-Disturbance Agreement. Lender hereby agrees that, at the written request of
Borrower, Lender will enter into a customary non-disturbance or similar agreement in connection with any Permitted License, in each case in form and substance reasonably satisfactory to Lender and the
other party or parties thereto. 
 13. DEFINITIONS 

13.1. Definitions. For the purposes of and as used in the Loan Documents: (a) references to any Person include its
successors and assigns and, in the case of any Governmental Authority, any Person succeeding to its functions and capacities; (b) except as the context otherwise requires (including to the extent otherwise expressly provided in any Loan
Document), (i) references to any law, treaty, order, policy, rule or regulation include amendments, supplements and successors thereto and (ii) references to any contract, agreement, instrument or other document (including any Contract) include
any amendments, restatements, supplements or modifications thereto from time to time to the extent permitted by the provisions thereof; (c) the word “shall” is mandatory; (d) the word “may” is permissive; (e) the
word “or” has the inclusive meaning represented by the phrase “and/or”; (f) the words “include”, “includes” and “including” are not limiting; (g) the singular includes the plural and the plural
includes the singular; (h) numbers denoting amounts that are set off in parentheses are negative unless the context dictates otherwise; (i) each authorization herein shall be deemed irrevocable and coupled with an interest; (j) all
accounting terms shall be interpreted, and all determinations relating thereto shall be made, in accordance with Applicable Accounting Standards; (k) references to any time of day shall be to New York time; (l) the words
“herein”, “hereof”, “hereby”, “hereto” and “hereunder” refer to this Agreement as a whole; and (m) references to specific sections, articles, annexes and exhibits are to this Agreement and
references to specific schedules are to the Disclosure Letter. As used in this Agreement, the following capitalized terms have the following meanings: 

“Account” means any “account” as defined in the Code with such additions to such term as may hereafter be made, and
includes all accounts receivable, book debts, and other sums owing to Credit Parties. 

  
 49 

 “Account Debtor” means any “account debtor” as defined in the
Code with such additions to such term as may hereafter be made. 
 “Acquisition” means (a) any Stock Acquisition or
(b) any Asset Acquisition. 
 “Additional Consideration” is defined in Section 2.7. 

“Adverse Proceeding” means any action, suit, proceeding, hearing (whether administrative, judicial or otherwise),
governmental investigation or arbitration (whether or not purportedly on behalf of any Credit Party or any of its Subsidiaries) at law or in equity, or before or by any Governmental Authority, domestic or foreign (including any Environmental
Claims), whether pending or, to the Knowledge of each Credit Party or any of its Subsidiaries, threatened in writing against any Credit Party or any of its Subsidiaries or any properties or assets of any Credit Party or any of its Subsidiaries. 

“Affiliate” means, with respect to any Person, each other Person that owns or controls directly or indirectly the Person, any
Person that controls or is controlled by or is under common control with the Person, and each of that Person’s senior executive officers, directors, partners and, for any Person that is a limited liability company or limited liability
partnership, that Person’s managers and members. As used in this definition, “control” means (a) direct or indirect beneficial ownership of at least fifty percent (50%) (or such lesser percentage which is the maximum allowed to
be owned by a foreign corporation in a particular jurisdiction) of the voting share capital or other equity interest in a Person or (b) the power to direct or cause the direction of the management of such Person by Contract or otherwise. 

“Agreement” is defined in the preamble hereof. 

“Anti-Terrorism Laws” means any Money Laundering Laws or other laws relating to terrorism or money laundering, including
Executive Order No. 13224 (effective September 24, 2001), the Patriot Act, the laws comprising or implementing the Bank Secrecy Act, and the laws administered by OFAC. 

“Applicable Accounting Standards” means with respect to Borrower and its Subsidiaries, generally accepted accounting
principles in the United States as set forth in the opinions and pronouncements of the Accounting Principles Board of the American Institute of Certified Public Accountants and statements and pronouncements of the Financial Accounting Standards
Board or in such other statements by such other Person as may be approved by a significant segment of the accounting profession, which are applicable to the circumstances as of the date of determination, consistently applied. 

“Assessments” is defined in Section 4.20(g). 

“Asset Acquisition” means, with respect to Borrower or any of its Subsidiaries, any purchase, inbound license or other
acquisition of any assets or properties of any other Person (or of any business, division, product line or line of business of any other Person (including rights in respect of any medical device)) other than the purchase, license or other
acquisition for administrative expenses and other ordinary course operating expenses; provided that, for the avoidance of doubt, “Asset Acquisition” includes any co-promotion or co-marketing arrangement for the assets or properties owned by another Person (other than Borrower or any of its Subsidiaries), pursuant to which upfront payments in excess of $5,000,000 are payable. Notwithstanding
the foregoing, an Asset Acquisition shall not include any license or grant described in Section 6.1(e). 

“Bankruptcy Code” means Title 11 of the United States Code entitled “Bankruptcy,” as now and hereafter in effect,
or any successor statute. 
 “Blocked Person” means (a) any Person listed in the annex to, or is otherwise subject to
the provisions of, Executive Order No. 13224, (b) a Person owned or controlled by, or acting for or on behalf of, any Person that is listed in the annex to, or is otherwise subject to the provisions of, Executive Order No. 13224, (c) a
Person with which Lender is prohibited from dealing or otherwise engaging in any transaction by any Anti-Terrorism Law, (d) a Person that commits, threatens or conspires to commit or supports “terrorism” as defined in Executive Order
No. 13224, or (e) a Person that is named a “specially designated national” or “blocked person” on the most current list published by OFAC or other similar list. 

  
 50 

 “Board of Directors” means, with respect to any Person, (i) in the
case of any corporation, the board of directors of such Person, (ii) in the case of any limited liability company, the board of managers of such Person, or if there is none, the Board of Directors of the managing member of such Person,
(iii) in the case of any partnership, the Board of Directors of the general partner of such Person and (iv) in any other case, the functional equivalent of the foregoing. 

“Board of Governors” means the Board of Governors of the United States Federal Reserve System, or any successor thereto. 

“Books” means all books and records including ledgers, federal, state and foreign Tax returns, records regarding a Credit
Party’s assets or liabilities, the Collateral, business operations or financial condition, and all computer programs or storage or any equipment containing such information. 

“Borrower” is defined in the preamble hereof. 

“Borrowing Resolutions” means, with respect to any Person, those resolutions adopted by such Person’s Board of Directors
and delivered by such Person to Lender approving the Loan Documents to which such Person is a party and the transactions contemplated thereby (including the Term Loan), together with a certificate executed by its Secretary on behalf of such Person
certifying that (a) such Person has the authority to execute, deliver, and perform its obligations under each of the Loan Documents to which it is a party, (b) that attached as Exhibit A to such certificate is a true, correct, and complete
copy of the resolutions then in full force and effect authorizing and ratifying the execution, delivery, and performance by such Person of the Loan Documents to which it is a party and (c) the name(s) of the Person(s) authorized to execute the Loan
Documents on behalf of such Person, together with a sample of the true signature(s) of such Person(s). 
 “Business Day”
means any day that is not a Saturday or a Sunday or a day on which banks are authorized or required to be closed in New York, New York or San Jose, California. 

“Cash Equivalents” means: (a) marketable direct obligations issued or unconditionally guaranteed by the United States or
any agency or any State thereof (provided that the full faith and credit of the United States is pledged in support thereof) having maturities of not more than twelve (12) months from the date of acquisition; (b) commercial paper
issued by any Person in the United States maturing no more than twelve (12) months after its creation and having the highest rating from either Standard & Poor’s Ratings Group or Moody’s Investors Service, Inc.; (c) Dollar
denominated certificates of deposit maturing no more than twelve (12) months after issue of any Lender or any commercial bank having, or which is the principal banking subsidiary of a bank holding company having, the highest long-term unsecured
debt rating from either Standard & Poor’s Ratings Group or Moody’s Investors Service, Inc.; (d) investments in money market funds substantially all of whose assets are comprised of securities of the types described in clauses
(a) through (c) above; (e) all foreign equivalents of the securities and investments described in clauses (a) through (d) above; and (f) investments permitted by Borrower’s investment policy
effective March 1, 2016 and previously made available to Lender. Notwithstanding the foregoing, “Cash Equivalents” do not include, and the Credit Parties and their Subsidiaries are prohibited from purchasing, purchasing participations
in, entering into any type of swap or other equivalent derivative transaction or otherwise holding or engaging in any ownership interest in, any type of debt instrument, including any corporate or municipal bonds with a long-term nominal maturity
for which the interest rate is reset through a Dutch auction and more commonly referred to as an auction rate security. 

“CFC” means a “controlled foreign corporation” within the meaning of Section 957(a) of the IRC. 

“CFC Holding Company” means a Domestic Subsidiary that is a United States person as defined in Section 7701(a)(3)
of the IRC, the sole material assets of which are Equity Interests in one or more CFCs and any Domestic Subsidiaries described in this definition. 

  
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 “Change in Control” means: (a) a transaction or series of related
transactions (including any merger or consolidation) in which any “person” or “group” (within the meaning of Section 13(d) and 14(d)(2) of the Exchange Act) is or becomes the “beneficial
owner” (as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of a sufficient number of shares of all classes of stock then outstanding of Borrower ordinarily entitled to vote in the
election of directors, empowering such “person” or “group” to elect a majority of the Board of Directors of Borrower, who did not have such power before such transaction; and (b) a transaction or series of related
transactions involving the sale, assignment, transfer or other conveyance of all or substantially all of the assets of Borrower and its Subsidiaries on a consolidated basis; provided, however, that an underwritten initial public
offering of the equity interests of Borrower that results in a listing of Borrower’s equity interests on a public securities exchange shall not be deemed a Change of Control event. 

“Change in Control Notice” is defined in Section 2.2(c)(ii). 

“Change in Law” means the occurrence, after the date of this Agreement, of any of the following: (a) the adoption or
taking into effect of any law, treaty, order, policy, rule or regulation, (b) any change in any law, treaty, order, policy, rule or regulation or in the administration, interpretation or application thereof by any Governmental Authority or
(c) the making or issuance of any request or directive (whether or not having the force of law) by any Governmental Authority; provided that notwithstanding anything herein to the contrary, (x) the Dodd-Frank Wall Street Reform and
Consumer Protection Act and all requests, rules or directives thereunder or issued in connection therewith and (y) all requests, rules or directives promulgated by the Bank for International Settlements, the Basel Committee on Banking
Supervision (or any successor or similar authority) or the United States or foreign regulatory authorities, in each case pursuant to Basel III, shall be deemed to be a “Change in Law”, regardless of the date enacted, adopted or issued.
Notwithstanding the foregoing, a “Change in Law” shall not include any amendment made to FATCA after the Tranche A Closing Date. 

“Code” means the Uniform Commercial Code, as the same may, from time to time, be enacted and in effect in the State of New
York; provided that, to the extent that the Code is used to define any term herein or in any Loan Document and such term is defined differently in different Articles of the Code, the definition of such term contained in Article 9 of the Code
shall govern; provided, further, that in the event that, by reason of mandatory provisions of law, any or all of the attachment, perfection, or priority of, or remedies with respect to, Lender’s Lien on any Collateral is governed
by the Uniform Commercial Code in effect in a jurisdiction other than the State of New York, the term “Code” shall mean the Uniform Commercial Code as enacted and in effect in such other jurisdiction solely for purposes of the provisions
thereof relating to such attachment, perfection, priority, or remedies and for purposes of definitions relating to such provisions. 

“Collateral” means, collectively, “Collateral” (as such term is defined in the Security Agreement) and all other
properties or assets of whatever kind and nature subject or purported to be subject from time to time to a Lien under any Collateral Document. 

“Collateral Account” means any Deposit Account, Securities Account or Commodity Account. 

“Collateral Documents” means the Security Agreement, the Control Agreements, the IP Agreements, any Mortgages and all other
landlord consents, bailee waivers, instruments, documents and Contracts delivered by any Credit Party pursuant to this Agreement or any of the other Loan Documents, in each case, in order to grant to Lender or perfect a Lien on any Collateral as
security for the Obligations, and all amendments, restatements, modifications or supplements thereof or thereto. 

“Commercialization” means, with respect to any Product, any activities undertaken with respect to commercialization of
such Product, including (a) advertising, promoting, marketing, offering, selling, importing, exporting, transporting, and distributing such Product, (b) strategic marketing or sales force detailing, educating, and liaising with the medical
community, (c) obtaining necessary licenses and authorization from applicable Governmental Authorities, (d) interacting with the FDA and other Governmental Authorities regarding any of the foregoing, and (e) producing, Manufacturing
and supplying such Product. “Commercialize” and “Commercialized” shall have comparable meanings. 

  
 52 

 “Commodity Account” means any “commodity account” as defined in
the Code with such additions to such term as may hereafter be made. 
 “Company IP” means any and all of the following, as
they exist throughout the world: (a) Current Company IP; (b) improvements, continuations, continuations-in-part, divisions, provisionals or any substitute
applications, any patent issued with respect to any of the Current Company IP, any reissue, reexamination, renewal or patent term extension or adjustment (including any supplementary protection certificate) of any such patent, and any confirmation
patent or registration patent or patent of addition based on any such patent, and all foreign counterparts of any of the foregoing; (c) trade secrets or trade secret rights, including any rights to unpatented inventions, know-how, operating manuals, confidential or proprietary information, research in progress, algorithms, data, databases, data collections, designs, processes, procedures, methods, protocols, materials, formulae,
drawings, schematics, blueprints, flow charts, models, strategies, prototypes, techniques, and the results of experimentation and testing, including samples, in each case, as specifically related to Product; (d) any and all IP Ancillary Rights
specifically relating to any of the foregoing; and (e) regulatory filings, submissions and approvals related to the Products. 

“Competitor” means a medical device company participating in the development, manufacture and commercialization of surgical
devices for the treatment of patients with lower back symptoms. 
 “Compliance Certificate” means that certain certificate
in the form attached hereto as Exhibit B. 
 “Confidential Information” is defined in
Section 11.8. 
 “Connection Income Taxes” means Other Connection Taxes that are imposed on or
measured by net income (however denominated) or that are franchise Taxes or branch profits Taxes. 
 “Consolidated EBITDA”
means, with respect to Borrower and its Subsidiaries on a consolidated basis for any period, an amount equal to Consolidated Net Income for such period, plus each of the following to the extent deducted in calculating such Consolidated Net
Income, without duplication: (i) Consolidated Net Interest Expense for such period; (ii) the sum of federal, state, local and foreign income Taxes accrued or paid in cash during such period; (iii) the amount of depreciation expense
deducted in determining Consolidated Net Income for such period; (iv) the amount of amortization expense deducted in determining Consolidated Net Income for such period; (v) any non-cash stock
compensation expense recorded pursuant to FASB 123R for such period; (vi) to the extent actually paid during such period, fees and expenses related to the consummation of the transactions contemplated to be closed on the Tranche A Closing Date;
(vii) transaction costs related to Permitted Acquisitions, Permitted Investments or any offering by Borrower of its Equity Interests during such period; and (viii) litigation costs. 

“Consolidated Net Income ” means, with respect to Borrower and its Subsidiaries on a consolidated basis for any period, the
net income (loss) of Borrower and its Subsidiaries for such period, determined on a consolidated basis and in accordance with Applicable Accounting Standards, but excluding from the determination of Consolidated Net Income (without
duplication): (a) any non-cash extraordinary or non-recurring gains or losses or non-cash gains or losses from Transfers for such
period; (b) any restructuring charges; (c) effects of discontinued operations in such period; (d) any Tax refunds, net operating losses or other net Tax benefits received during such period on account of any prior period; and
(e) the net income (or loss) of any Person accrued prior to the date (x) it becomes a Subsidiary of Borrower or (y) all or substantially all of the properties or assets of such Person are acquired by a Subsidiary of Borrower, in each
case, determined on a consolidated basis and in accordance with Applicable Accounting Standards. 
 “Consolidated Net Interest
Expense” means, with respect to Borrower and its Subsidiaries on a consolidated basis for any period, total interest expense (including mark-to- market interest
expense with respect to any warrants to purchase Equity Interests of Borrower), premium payments, debt discount, fees, charges and related expenses with respect to all outstanding Indebtedness (including Permitted Hedging Agreements) of Borrower and
its Subsidiaries for such period, determined on a consolidated basis and in accordance with Applicable Accounting Standards (including interest expense paid to Affiliates of Borrower), less interest income of Borrower and its Subsidiaries for
such period, determined on a consolidated basis and in accordance with Applicable Accounting Standards. 

  
 53 

 “Consulting Royalties” means, with respect to any health care professional
or other Person who is a counterparty to a health care professional consulting agreement or similar Contract with Borrower or any of its Subsidiaries, royalty payments due to, or obligations to make royalty payments to or enter into Contracts to pay
royalties to, such Person arising out of consulting services provided to Borrower or any of its Subsidiaries relating to product development; provided that in no event shall Consulting Royalties under any such agreement or Contract exceed
more than eight percent (8%) of sales of the product identified in such agreement or Contract. 
 “Contingent Obligation”
means, for any Person, any direct or indirect liability, contingent or not, of that Person for (a) any indebtedness, lease, dividend, letter of credit or other obligation of another Person directly or indirectly guaranteed, endorsed, co-made, discounted or sold with recourse by that Person, or for which that Person is directly or indirectly liable; (b) any obligation for undrawn letters of credit for the account of that Person; or
(c) any obligation to pay contingent or deferred consideration or other payments to a counterparty in connection with an Acquisition or a sale or other disposition or under any co-promotion or co-marketing arrangement, including, with respect to any purchase price holdback in respect of a portion of the purchase price of an asset sold to such Person to satisfy unperformed obligations of the seller of such
asset, any obligation to pay such seller the excess of such holdback over such obligations; provided that “Contingent Obligation” does not include endorsements in the ordinary course of business. The amount of a Contingent
Obligation is the stated or determined amount of the primary obligation for which the Contingent Obligation is made or, if not determinable, the maximum reasonably anticipated liability for it reasonably determined by such Person in good faith, but
the amount may not exceed the maximum of the obligations under any guarantee or other support arrangement. 
 “Contract”
means any agreement, lease, deed, sublease, other occupancy agreement, contract, note, mortgage, license, instrument, note, indenture, commitment, undertaking, joint venture or any other agreement, understanding, commitment or legally binding
obligation or arrangement, whether written or oral. 
 “Control Agreement” means any control Contract entered into among
the depository institution at which a Credit Party maintains a Deposit Account or the securities intermediary or commodity intermediary at which a Credit Party maintains a Securities Account or a Commodity Account, such Credit Party and (a) if
Borrower incurs any Permitted Indebtedness pursuant to clause (e) of the definition of Permitted Indebtedness, the lender in respect of such Permitted Indebtedness, so long as such lender shall have agreed to hold control over such
Deposit Account, Securities Account or Commodity Account for the benefit of Lender or (b) in all other cases, Lender, pursuant to which Lender obtains control (within the meaning of the Code) over such Deposit Account, Securities Account or
Commodity Account. 
 “Copyrights” means any and all copyright rights, copyright applications, copyright registrations and
like protections in each work of authorship and derivative work thereof, whether published or unpublished and whether or not the same also constitutes a trade secret (and all related IP Ancillary Rights). 

“Credit Extension” means any Term Loan or any other extension of credit by Lender for Borrower’s 

benefit. 
 “Credit Party” means
each of Borrower and any Guarantor. 
 “Cure Amount” is defined in Section 6.17(c). 

“Cure Right” is defined in Section 6.17(c). 

“Current Company IP” means any and all Intellectual Property pending, registered or issued, which is owned by or exclusively
licensed to any of the Credit Parties or any of their Subsidiaries or that any of the Credit Parties or any of their Subsidiaries has the right to acquire or license. 

“Current Company IP Agreement” means any Contract, pursuant to which any Credit Party or any of its Subsidiaries has the
legal right to exploit Current Company IP that is owned by another Person for the Manufacture, use, Commercialization or supply of any Product. 

“Customer Data” is defined in Section 4.5(w). 

  
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 “Default” means an event which, with the giving of notice or the lapse of
time or both, would constitute an Event of Default. 
 “Deposit Account” means any “deposit account” as defined
in the Code with such additions to such term as may hereafter be made. 
 “Disclosure Letter” means the disclosure letter,
dated as of the Effective Date, delivered by Borrower to Lender, as updated on the Tranche A Closing Date (if required), on the Tranche B Closing Date (if applicable) and from time to time pursuant to the terms of this Agreement. 

“Disqualified Equity Interest” means, with respect to any Person, any Equity Interest in such Person that by its terms (or by
the terms of any security into which it is convertible or for which it is exchangeable, either mandatorily or at the option of the holder thereof), or upon the happening of any event or condition: 

(i) matures or is mandatorily redeemable (other than solely for Equity Interests in such Person that do not constitute Disqualified Equity
Interests and cash in lieu of fractional shares of such Equity Interests), whether pursuant to a sinking fund obligation or otherwise; 

(ii) is convertible or exchangeable at the option of the holder thereof for Indebtedness or Equity Interests (other than solely for Equity
Interests in such Person that do not constitute Disqualified Equity Interests and cash in lieu of fractional shares of such Equity Interests); or 

(iii) is or may be redeemable (other than solely for Equity Interests in such Person that do not constitute Disqualified Equity Interests and
cash in lieu of fractional shares of such Equity Interests) or is or may be required to be repurchased by such Person or any of its Affiliates (other than, at the option of such Person, solely for Equity Interests in such Person that do not
constitute Disqualified Equity Interests and cash in lieu of fractional shares of such Equity Interests), in whole or in part, at the option of the holder thereof; 

in each case, on or prior to the date that occurs 91 days after the Term Loan Maturity Date; provided, however, that any Equity
Interests that would not constitute Disqualified Equity Interests but for provisions thereof giving holders thereof the right to require such Person to purchase or redeem such Equity Interests upon the occurrence of an “asset sale,”
“fundamental change” or “change of control” occurring prior to the date that is 91 days after the Term Loan Maturity Date shall not constitute Disqualified Equity Interest if the “asset sale,” “fundamental
change” or “change of control” provisions applicable to such Equity Interests are not more favorable to the holders of such Equity Interests than Section 6.1 and the provisions relating to a Change in Control
contained herein; provided, further, however, that, if such Equity Interests are issued to any plan for the benefit of directors, managers, employees or consultants of Borrower or its Subsidiaries or by any such plan to such
directors, managers, employees or consultants, such Equity Interests shall not constitute Disqualified Equity Interest solely because they may be required to be repurchased by Borrower or its Subsidiaries in order to satisfy applicable statutory or
regulatory obligations. 
 “Dollars,” “dollars” or use of the sign “$” means only lawful
money of the United States and not any other currency, regardless of whether that currency uses the “$” sign to denote its currency or may be readily converted into lawful money of the United States. 

“Domestic Subsidiary” means, with respect to any Credit Party, a Subsidiary of such Credit Party that is incorporated or
organized under the laws of the United States. 
 “Effective Date” is defined in the preamble hereof. 

“Environmental Claim” means any investigation, notice, notice of violation, claim, action, suit, proceeding, demand,
abatement order or other order or directive (conditional or otherwise), by any Governmental Authority or any other Person, arising (i) pursuant to or in connection with any actual or alleged violation of any Environmental Law; (ii) in
connection with any Hazardous Material or any actual or alleged Hazardous Materials Activity; or (iii) in connection with any actual or alleged damage, injury, threat or harm to health, safety, natural resources or the environment. 

  
 55 

 “Environmental Laws” means any and all current or future foreign or
domestic, federal or state (or any subdivision of either of them), statutes, ordinances, orders, rules, regulations, judgments, Governmental Approvals, or any other requirements of Governmental Authorities relating to (i) environmental matters,
including those relating to any Hazardous Materials Activity; (ii) the generation, use, storage, transportation or disposal of Hazardous Materials; or (iii) occupational safety and health, industrial hygiene, land use or the protection of
human, plant or animal health or welfare, in each case, in any manner applicable to any Credit Party or any of its Subsidiaries or any Facility. 

“Equipment” means all “equipment” as defined in the Code with such additions to such term as may hereafter be made,
and includes all machinery, fixtures, goods, vehicles (including motor vehicles and trailers), and any interest in any of the foregoing. 

“Equity Cure Right” is defined in Section 6.17(c). 

“Equity Interests” means, with respect to any Person, any and all shares, interests, participations or other equivalents
(however designated) of capital stock of a corporation, any and all equivalent ownership interests in such Person (other than a corporation), including partnership interests and membership interests, and any and all warrants, rights or options to
purchase or other arrangements or rights to acquire (by purchase, conversion, dividend, distribution or otherwise) any of the foregoing (including through convertible securities), and all other rights, powers, privileges, interests, claims and other
property in any manner arising therefrom or relating thereto. 
 “ERISA” means the Employee Retirement Income Security Act
of 1974, and its regulations. 
 “ERISA Affiliate” means, with respect to any person, any trade or business (whether or not
incorporated) that, together with such person, is treated as a single employer under Section 414 of the IRC. 
 “ERISA
Event” means (a) any “reportable event,” as defined in Section 4043 of ERISA or the regulations issued thereunder, with respect to a Plan (other than an event for which the 30-day
notice period is waived by regulation); (b) with respect to a Plan, the failure to satisfy the minimum funding standard of Section 412 of the IRC and Section 302 of ERISA, whether or not waived; (c) the failure to make by its due date
a required installment under Section 430(j) of the IRC (or Section 430(j) of the IRC, as amended by the Pension Protection Act of 2006) with respect to any Plan or the failure to make any required contribution to a Multiemployer Plan;
(d) the filing pursuant to Section 412(c) of the IRC or Section 303(d) of ERISA (or after the effective date of the Pension Protection Act of 2006, Section 412(c) of the IRC and Section 302(c) of ERISA) of an application for
a waiver of the minimum funding standard with respect to any Plan; (e) the incurrence by Borrower or any of its ERISA Affiliates of any liability under Title IV of ERISA with respect to the termination of any Plan; (f) the receipt by
Borrower or its Subsidiaries or any of their respective ERISA Affiliates from the Pension Benefit Guaranty Corporation (referred to and defined in ERISA) or a plan administrator of any notice relating to the intention to terminate any Plan or Plans
or to appoint a trustee to administer any Plan, or the occurrence of any event or condition which could reasonably be expected to constitute grounds under ERISA for the termination of, or the appointment of a trustee to administer, any Plan;
(g) the incurrence by Borrower or its Subsidiaries or any of their respective ERISA Affiliates of any liability with respect to the withdrawal from any Plan or Multiemployer Plan; (h) the receipt by Borrower or its Subsidiaries or any of
their respective ERISA Affiliates of any notice, concerning the imposition of Withdrawal Liability or a determination that a Multiemployer Plan is, or is expected to be, insolvent or in reorganization, within the meaning of Title IV of ERISA;
(i) the “substantial cessation of operations” within the meaning of Section 4062(e) of ERISA with respect to a Plan; (j) the making of any amendment to any Plan which could result in the imposition of a lien or the posting
of a bond or other security; and (k) the occurrence of a nonexempt prohibited transaction (within the meaning of Section 4975 of the IRC or Section 406 of ERISA) which could reasonably be expected to result in material liability to
Borrower or its Subsidiaries. 
 “Event of Default” is defined in Section 7. 

“Event of Loss” means, with respect to any properties or assets, any of the following: (a) any loss, destruction or
damage of such properties or assets; (b) any transfer in lieu of any pending or threatened (in writing) institution of any proceedings for the condemnation or seizure of such properties or assets or for the exercise of any right of eminent
domain; or (c) any actual condemnation, seizure or taking, by exercise of the power of eminent domain or otherwise, of such properties or assets, or confiscation of such properties or assets or the requisition of the use of such properties or
assets. 

  
 56 

 “Exchange Act” means the Securities Exchange Act of 1934. 

“Excluded Accounts” is defined in Section 5.6. 

“ Excluded Equity Interests” means, collectively, (i) any Equity Interests of any Domestic Subsidiary indirectly owned
by a Credit Party through a Foreign Subsidiary; (ii) any voting stock in excess of 65% of the issued and outstanding voting stock of any Foreign Subsidiary directly owned by any Credit Party or any Domestic Subsidiary directly owned by any
Credit Party that is a CFC Holding Company which, pursuant to Section 5.14, is not required to be pledged to secure the Obligations; (iii) any Equity Interests of any other Domestic Subsidiary with respect to which,
Borrower and Lender reasonably determine by mutual agreement that the cost of granting Lender a security interest, in and Lien upon, and pledging to Lender, such Equity Interests, to secure the Obligations (and any guaranty thereof) are excessive,
relative to the value to be afforded to Lender thereby; (iv) any Equity Interests of any other Domestic Subsidiary with respect to which, Borrower and Lender reasonably determine by mutual agreement that the grant to Lender of a security
interest in and Lien upon, and the pledge to Lender of, such Equity Interests, to secure the Obligations (and any guaranty thereof) are validly prohibited by Requirement of Law; (v) any Equity Interests of any other Domestic Subsidiary with
respect to which, Borrower and Lender reasonably determine by mutual agreement that the grant to Lender of a security interest in and Lien upon, and the pledge to Lender of, such Equity Interests, to secure the Obligations (and any guaranty thereof)
require the consent, approval or waiver of any Governmental Authority or other third party and such consent, approval or waiver has not been obtained by Borrower following Borrower’s commercially reasonable efforts to obtain the same; and
(vi) any Equity Interests of any other Domestic Subsidiary that is a non-Wholly-Owned Subsidiary, with respect to which, Borrower and Lender reasonably determine by mutual agreement that the grant to Lender of a security interest in and Lien
upon, and the pledge to Lender of, such Equity Interests, to secure the Obligations (and any guaranty thereof) are validly prohibited by, or would give any third party (other than Borrower or an Affiliate of Borrower) the right to terminate its
obligations under, the Operating Documents of the joint venture agreement or shareholder agreement with respect to, or any other contract with such third party relating to such non-Wholly-Owned Subsidiary
(other than customary non-assignment provisions which are ineffective under Article 9 of the Code or other Requirement of Law), but only, in each case, to the extent, and for so long as such Operating
Document, joint venture agreement, shareholder agreement or other contract is in effect and Borrower has not obtained the consent, approval or waiver of such third party following Borrower’s commercially reasonable efforts to obtain the same.

 “Excluded License” means an exclusive license or sublicense of any Intellectual Property covering any Product that is
tantamount to a sale of substantially all rights to such Intellectual Property in a particular geography or field of use because it conveys to the licensee or sublicensee exclusive rights to practice such Intellectual Property in the applicable
geography or field of use for consideration that is not based upon future development or Commercialization of any Product (other than pursuant to so-called earn-out
payments) or services by the licensee or sublicensee (other than transition services), such as, for example, consideration of only upfront advances or initial license fees or similar payments in consideration of such rights, with no anticipated
subsequent payments or de minimis payments to Borrower or any of its Subsidiaries (other than pursuant to so-called earn-out payments or transition
services). 
 “Excluded Subsidiaries” means, collectively, (i) any Domestic Subsidiary owned indirectly by any Credit
Party through a Foreign Subsidiary; (ii) any Subsidiary with respect to which, Borrower and Lender reasonably determine by mutual agreement that the grant to Lender of a security interest in and Lien upon, and the pledge to Lender of, such
Subsidiary’s properties and assets constituting Collateral and the Equity Interests of such Subsidiary, to secure the Obligations (and any guaranty thereof) are validly prohibited by Requirements of Law; (iii) any other Subsidiary with
respect to which, Borrower and Lender reasonably determine by mutual agreement that the grant to Lender of a security interest in and Lien upon, and the pledge to Lender of, such Subsidiary’s properties and assets constituting Collateral and
the Equity Interests of such Subsidiary, to secure the Obligations (and any guaranty thereof) require the consent, approval or waiver of any Governmental Authority or other third party (other than Borrower or an Affiliate of Borrower) and such
consent, approval or waiver has not been obtained by Borrower or such Subsidiary following Borrower’s and such Subsidiary’s commercially reasonable efforts to obtain the same; (iv) any other Subsidiary that is a non-Wholly-Owned Subsidiary, with respect to which, Borrower and Lender 

  
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 reasonably determine by mutual agreement that the grant to Lender of a security interest in and Lien upon,
and the pledge to Lender of, such non-Wholly-Owned Subsidiary’s properties and assets constituting Collateral and the Equity Interests of such non-Wholly-Owned
Subsidiary, to secure the Obligations (and any guaranty thereof) are validly prohibited by the Operating Documents of such non-Wholly-Owned Subsidiary, but only, in each case, to the extent, and for so long as
such Operating Documents are in effect; (v) any other Subsidiary that is a non-Wholly-Owned Subsidiary, with respect to which, Borrower and Lender reasonably determine by mutual agreement that the grant
to Lender of a security interest in and Lien upon, and the pledge to Lender of, such non-Wholly-Owned Subsidiary’s properties and assets constituting Collateral and the Equity Interests of such non-Wholly-Owned Subsidiary, to secure the Obligations (and any guaranty thereof) are validly prohibited by, or would give any third party (other than Borrower or an Affiliate of Borrower) the right to terminate its
obligations under, the joint venture agreement or shareholder agreement with respect to, or any other Contract with such third party relating to, such non-Wholly-Owned Subsidiary (other than customary non-assignment provisions which are ineffective under Article 9 of the Code or other Requirements of Law), but only, in each case, to the extent, and for so long as such joint venture agreement, shareholder
agreement or other Contract is in effect, and Borrower has not obtained the consent, approval or waiver of such third party following Borrower’s commercially reasonable efforts to obtain the same; and (vi) any other Subsidiary with respect
to which, Borrower and Lender reasonably determine by mutual agreement that the cost of granting Lender a security interest in and Lien upon, and pledging to Lender, such Subsidiary’s properties and assets constituting Collateral and the Equity
Interests of such Subsidiary, to secure the Obligations (and any guaranty thereof) are excessive relative to the value to be afforded to Lender thereby. 

“Excluded Taxes” means any of the following Taxes imposed on or with respect to a Lender or required to be withheld or
deducted from a payment to a Lender: (a) Taxes imposed on or measured by net income (however denominated), franchise Taxes, and branch profits Taxes, in each case, (i) imposed as a result of such Lender being organized under the laws of,
or having its principal office or its applicable lending office located in, the jurisdiction imposing such Tax (or any political subdivision thereof) or (ii) that are otherwise Other Connection Taxes; (b) U.S. federal withholding Taxes
imposed on amounts payable to or for the account of such Lender with respect to any Obligation pursuant to a law in effect on the date on which (i) such Lender acquires an interest in any Obligation or (ii) such Lender changes its lending
office (other than pursuant to a request from Borrower), except in each case to the extent that, pursuant to Section 2.6, amounts with respect to such Taxes were payable either to such Lender’s assignor immediately
before such Lender became a party hereto or to such Lender immediately before it changed its lending office, (c) Taxes attributable to such Lender’s failure to comply with Section 2.6(c), and (d) any U.S.
federal withholding Taxes imposed under FATCA. 
 “Existing Oxford Loan Agreement” means, collectively, that certain Loan
and Security Agreement, dated as of October 20, 2015, among Oxford Finance LLC, a Delaware limited liability company, as collateral agent, the lenders party thereto from time to time and Borrower, as may be amended, restated, supplemented or
otherwise modified, together with each other Loan Document (as such term is defined in the Existing Oxford Loan Agreement). 

“Facility” means any real property (including all buildings, fixtures or other improvements located thereon) now, hereafter
or heretofore owned, leased or operated by any Credit Party or any of its Subsidiaries or any of its or their respective predecessors or Affiliates; provided, however, that solely with respect to any leased office space,
“Facility” shall include only those premises which are actually leased by such applicable Credit Party or Subsidiary. 

“FATCA” means Sections 1471 through 1474 of the IRC, as of the date of this Agreement (including, for the avoidance of doubt,
any agreements between the governments of the United States and the jurisdiction in which the applicable Lender is resident implementing such provisions),or any amended or successor version that is substantively comparable and not materially more
onerous to comply with, and any current or future regulations promulgated thereunder or official interpretations thereof, any agreements entered into pursuant to Section 1471(b)(i) of the IRC and any law implementing an intergovernmental
agreement that is included in this definition. 
 “FCPA” is defined in Section 4.18(a). 

“FDA” means the United States Food and Drug Administration (and any foreign equivalent). 

  
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 “FDA Good Manufacturing Practices” means the current good manufacturing
practices requirements as set forth in the quality system regulation 21 C.F.R. Part 820 and the Canadian equivalent set forth in ISO 13485. 

“FDA Laws” means all applicable statutes, rules, regulations, standards, policies and orders administered or issued by FDA
(and any foreign equivalent), including the FDA’s Fraud, Untrue Statements of Material Facts, Bribery and Illegal Gratuities Final Policy. 

“FDA Registration and Listing Requirements” means the registration and listing requirements set forth in 21 U.S.C. § 360
and 21 C.F.R. Part 807 and all similar Requirements of Law (and any foreign equivalent). 
 “FDCA” is defined in
Section 4.20(b). 
 “Federal Reserve Board” means the Board of Governors of the Federal Reserve
System. 
 “Foreign Subsidiary” means, with respect to any Credit Party, any Subsidiary of such Credit Party that is not a
Domestic Subsidiary. 
 “Governmental Approval” means any consent, authorization, approval, order, license, franchise,
permit, certificate, accreditation, registration, filing or notice, of, issued by, from or to, or other act by or in respect of, any Governmental Authority. 

“Governmental Authority” means any nation or government, any state or other political subdivision thereof, any agency,
government department, authority, instrumentality, regulatory body, court, central bank or other entity exercising executive, legislative, judicial, taxing, regulatory or administrative functions of or pertaining to government, any securities
exchange and any self-regulatory organization, in each case, whether domestic or foreign. 
 “Governmental Payor Programs”
means all governmental third party payor programs in which any Credit Party or its Subsidiaries participates, including Medicare, Medicaid, TRICARE or any other federal or state health care programs (and any foreign equivalent). 

“Guarantor” means any Domestic Subsidiary that is a present or future guarantor of the Obligations. 

“Hazardous Materials” means any chemical, material or substance, exposure to which is prohibited, limited or regulated by any
Governmental Authority or which may or could pose a hazard to the health and safety of the owners, occupants or any Persons in the vicinity of any Facility or to the indoor or outdoor environment. 

“Hazardous Materials Activity” means any past, current, proposed or threatened (in writing) activity, event or occurrence
involving any Hazardous Materials, including the use, manufacture, possession, storage, holding, presence, existence, location, Release, threatened (in writing) Release, discharge, placement, generation, transportation, processing, construction,
treatment, abatement, removal, remediation, disposal, disposition or handling of any Hazardous Materials, and any corrective action or response action with respect to any of the foregoing. 

“Health Care Laws” means, collectively: (a) any and all federal, state or local laws, rules, regulations, orders,
ordinances, statutes and requirements issued under or in connection with Medicare, Medicaid or any other Government Payor Program; (b) federal and state laws and regulations governing the confidentiality of patient information, including HIPAA;
(c) accreditation standards and requirements of all applicable state laws or regulatory bodies; (d) any and all federal, state and local fraud and abuse laws of any Governmental Authority, including the federal Anti-Kickback Statute (42
U.S.C. § 1320a-7(b)), the civil False Claims Act (31 U.S.C. § 3729 et seq.), Sections 1320a-7 and 1320a-7a of Title 42
of the United States Code and the regulations promulgated pursuant to such statutes; (e) any and all Requirements of Law relating to the billing or submission of claims to Government Payor Programs or other third party payors; (f) the
Physician Payment Sunshine Act (42 U.S.C. § 1320a-7h); (g) California Health & Safety Code §§ 119400 – 119402; (h) all other applicable health care laws, rules, codes, statutes,
regulations, orders, ordinances, policies, administrative guidance and requirements pertaining to Medicare or Medicaid, in each case, in any manner applicable to any Credit Party or any of its Subsidiaries; (i) any 

  
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 and all federal, state or local laws, rules, regulations, ordinances, statutes and requirements relating to
billings to insurance companies, health maintenance organizations and other Managed Care Plans or otherwise relating to insurance fraud; and (j) any and all foreign health care laws, rules, codes, regulations, orders, ordinances, statutes and
requirements which, in each case, are analogous to any of the foregoing and applicable to any Credit Party or any of its Subsidiaries in any manner. 

“Hedging Agreement” means any interest rate, currency, commodity or equity swap, collar, cap, floor or forward rate
agreement, or other Contract or arrangement designed to protect a Person against fluctuations in interest rates, currency exchange rates or commodity or equity prices or values (including any option with respect to any of the foregoing and any
combination of the foregoing agreements, Contracts or arrangements), and any confirmation executed in connection with any such agreement, Contract or arrangement. 

“HIPAA” means the Health Insurance Portability and Accountability Act of 1996, any and all rules or regulations promulgated
from time to time thereunder, and any comparable U.S. state laws. 
 “HIPAA Compliance Plan” is defined in
Section 4.20(g). 
 “Indebtedness” means, with respect to any Person, without duplication:
(a) all indebtedness for advanced or borrowed money of such Person; (b) all obligations issued, undertaken or assumed by such Person as the deferred purchase price of property, services or rights (other than (i) accrued expenses and
trade payables entered into in the ordinary course of business that are not more than one hundred twenty (120) days past due or subject to a bona fide dispute, (ii) obligations to pay for services provided by employees and individual
independent contractors in the ordinary course of business that are not more than one hundred twenty (120) days past due or subject to a bona fide dispute (including any obligations in respect of deferred compensation and severance, pension,
health and welfare retirement and equivalent benefits to current or former employees, directors, officers, consultants or managers of any acquired Person and its Subsidiaries in connection with any Permitted Acquisition), (iii) liabilities
associated with customer prepayments and deposits and (iv) prepaid or deferred revenue arising in the ordinary course of business), including any obligation or liability to pay deferred or contingent purchase price or other consideration for
such property, services or rights; (c) the face amount of all letters of credit issued for the account of such Person and, without duplication, all drafts drawn thereunder and all reimbursement or payment obligations with respect to letters of
credit, surety bonds, performance bonds and other similar instruments issued by such Person; (d) all obligations of such Person evidenced by notes, bonds, debentures or other debt securities or similar instruments (including debt securities
convertible into Equity Interests), including obligations so evidenced incurred in connection with the acquisition of properties, assets or businesses; (e) all indebtedness of such Person created or arising under any conditional sale or other
title retention agreement, or incurred as financing, in either case with respect to property acquired by such Person (even though the rights and remedies of the seller or bank under such agreement in the event of default are limited to repossession
or sale of such property); (f) all capital lease obligations of such Person; (g) the principal balance outstanding under any synthetic lease, off-balance sheet loan or similar off balance sheet financing
product provided to such Person; (h) all Disqualified Equity Interests (excluding any accrued dividends); (i) all indebtedness referred to in clauses (a) through (h) above of other Persons secured by (or for which the holder
of such Indebtedness has an existing right, contingent or otherwise, to be secured by) any Lien upon or in property (including accounts and contracts rights) owned by such Person, even though such Person has not assumed or become liable for the
payment of such indebtedness; and (j) all Contingent Obligations. 
 “Indemnified Liabilities” means, collectively,
any and all liabilities, obligations, losses, damages (including natural resource damages), penalties, claims, actions, judgments, suits, costs, expenses and disbursements in connection with any investigative, administrative or judicial proceeding
or hearing commenced or threatened in writing by any Person, whether or not any such Indemnified Person shall have commenced such proceeding or hearing or be designated as a party or a potential party thereto, and any fees or expenses incurred by
Indemnified Persons in enforcing the indemnity hereunder (including the reasonable and documented fees and disbursements of counsel for Indemnified Persons (it being agreed that such legal counsel fees and expenses shall be limited to one primary
counsel and one Intellectual Property counsel (if and to the extent applicable) for the Indemnified Persons, except in the case of actual or potential conflicts of interest between or among the Indemnified Persons)), whether direct, indirect or
consequential and whether based on any federal, state or foreign laws, statutes, rules or regulations, on common law or equitable cause or on contract or otherwise, that may be imposed on, incurred by, or asserted against any such Indemnified
Person, in any manner relating to or arising out of this Agreement or the other 

  
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 Loan Documents or the transactions contemplated hereby or thereby (including Lender’s agreement to make
the Credit Extensions or the use or intended use of the proceeds thereof, or any enforcement of any of the Loan Documents (including any sale of, collection from, or other realization upon any of the Collateral or the enforcement of any guaranty of
the Obligations)). 
 “Indemnified Person” is defined in Section 11.2(a). 

“Indemnified Taxes” means (a) Taxes, other than Excluded Taxes, imposed on or with respect to any payment made by or on
account of any obligation of any Credit Party under any Loan Document and (b) to the extent not otherwise described in clause (a) above, Other Taxes. 

“Insolvency Proceeding” means, with respect to any Person, any proceeding by or against such Person under the United States
Bankruptcy Code, or any other bankruptcy or insolvency law, including assignments for the benefit of creditors, compositions, extensions generally with its creditors, or proceedings seeking reorganization, arrangement, or other relief. 

“Intellectual Property” means all: 

(a) Copyrights, Trademarks, and Patents; 

(b) trade secrets and trade secret rights, including any rights to unpatented inventions, know-how,
operating manuals; 
 (c) Software (as such term is defined in the Security Agreement); 

(d) Internet Domain Names (as such term is defined in the Security Agreement); 

(e) design rights; 
 (f) IP
Ancillary Rights; and 
 (g) any similar or equivalent rights to any of the foregoing anywhere in the world. 

“Inventory” means all “inventory” as defined in the Code in effect on the date hereof with such additions to such
term as may hereafter be made, and includes all merchandise, raw materials, parts, supplies, packing and shipping materials, work in process and finished products, including such inventory as is temporarily out of a Credit Party’s custody or
possession or in transit and including any returned goods and any documents of title representing any of the above. 

“Investment” means (i) any beneficial ownership interest in any Person (including Equity Interests), (ii) any
Acquisition or (iii) the making of any advance, loan, extension of credit or capital contribution in or to, any Person. 
 “IP
Agreements” means those certain Intellectual Property Security Agreements entered into by and between Borrower and Lender, each dated as of the Tranche A Closing Date, as such may be amended, restated, supplemented or otherwise modified
from time to time. 
 “IP Ancillary Rights” means, with respect to any Copyright, Trademark, Patent, Software, trade
secrets or trade secret rights, including any rights to unpatented inventions, know-how, operating manuals, all income, royalties, proceeds and liabilities at any time due or payable or asserted under or with respect to any of the foregoing or
otherwise with respect thereto, including all rights to sue or recover at law or in equity for any past, present or future infringement, misappropriation, dilution, violation or other impairment thereof, and, in each case, all rights to obtain any
other intellectual property right ancillary to any Copyright, Trademark, Patent, Software, trade secrets or trade secret rights. 

  
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 “IRC” means the Internal Revenue Code of 1986, as amended, and any
regulations promulgated thereunder. 
 “Knowledge” or to the “Knowledge” of any Credit Party or any
Subsidiaries of any Credit Party means the actual knowledge, after reasonable investigation, of each of the Chief Executive Officer, Chief Financial Officer, Chief Commercial Officer, Chief Technology Officer, Chief Medical Officer, Chief Compliance
Office, President, Vice-President and General Counsel of each Credit Party and each of its Subsidiaries. 
 “Lender” is
defined in the preamble hereof and shall include any successors or assigns. 
 “Lender Expenses” means all reasonable and
documented costs, fees and expenses of Lender incurred in connection with preparing, amending, supplementing, modifying, negotiating, executing and delivering, administering, defending or enforcing, or otherwise preserving its rights and
entitlements under, the Loan Documents (including those incurred in connection with appeals or Insolvency Proceedings) or otherwise incurred with respect to the Credit Parties in connection with the Loan Documents, including in all cases the
reasonable and documented fees and expenses of legal counsel and any filing or recording fees and expenses (it being agreed that such legal counsel fees and expenses shall be limited to one primary counsel and one Intellectual Property counsel for
Lender. 
 “Lender Transfer” is defined in Section 11.1. 

“Lien” means a claim, mortgage, deed of trust, levy, charge, pledge, security interest or other encumbrance of any kind or
assignment for security purposes, whether voluntarily incurred or arising by operation of law or otherwise against any properties or assets. 

“Liquidity” means, on any date of determination, the sum of the Credit Parties’ unrestricted cash and Cash Equivalents
plus any unused availability under any revolving line of credit (not prohibited under the terms of this Agreement or any other Loan Document) on such date. 

“Loan Documents” means, collectively, this Agreement, the Disclosure Letter, the Term Loan Note, the Security Agreement, the
IP Agreements, each Compliance Certificate, the Perfection Certificate, any Control Agreement, any other Collateral Document, any guaranties executed by a Credit Party and any other present or future Contract between a Credit Party and Lender in
connection with this Agreement, as such may be amended, restated, supplemented or otherwise modified from time to time (including, for the avoidance of doubt, any annexes, exhibits or schedules thereto). 

“Makewhole Amount” means, on any date of determination occurring prior to the
30-month anniversary of the Tranche A Closing Date, an amount equal to the sum of all interest accruing from such date through the 30-month anniversary of the Tranche A
Closing Date. 
 “Managed Care Plans” means all health maintenance organizations, preferred provider organizations,
individual practice associations, competitive medical plans and similar arrangements. 
 “Manufacturing” means, with
respect to any Product, any or all of the manufacturing services for the manufacture of such Product, including testing and releasing test material, compounds, raw materials or substances and packaging materials required or used in connection
therewith, manufacturing, packaging, labeling, storing, inspecting, release testing and stability storage and testing of such Product. “Manufacture” and “Manufactured” shall have comparable meanings. 

“Manufacturing Agreements” is defined in Section 4.22(c). 

“Margin Stock” is defined in Section 4.13. 

“Material Adverse Change” means any material adverse change in or material adverse effect on: (i) the business,
condition (financial or otherwise), assets (including all or a material portion of the Collateral), liabilities (actual or contingent), operations, management, performance or properties of the Credit Parties, taken as a whole, 

  
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 since December 31, 2016; (ii) without limiting the generality of clause (i) above, any
rights in or related to any material Product, individually, or the Products, taken as a whole, or the Commercialization, research or clinical development of any material Product, individually, or the Products, taken as a whole; (iii) the
ability of Borrower, individually, or the Credit Parties, taken as a whole, to fulfill the payment or performance obligations under this Agreement or any other Loan Document to which it is party or they are parties (including as a result of Borrower
failing to remain Solvent, Borrower and its Subsidiaries that are Credit Parties, on a consolidated basis, failing to remain Solvent, or Borrower and its Subsidiaries, on a consolidated basis, failing to remain Solvent); or (iv) the binding
nature or validity of, or the ability of Lender to enforce, this Agreement or any other Loan Document or any of its rights or remedies hereunder or thereunder. Notwithstanding anything to the contrary herein, an adverse reimbursement decision by an
insurance company in respect of a Product shall not be a “Material Adverse Change.” 
 “Material Contract” means
any Contract to which a Credit Party or any of its Subsidiaries is a party (other than the Loan Documents) or by which any of its assets is bound (as such may be amended, restated, supplemented or otherwise modified from time to time), for which
breach, nonperformance, cancellation, termination or failure to renew could reasonably be expected to result in a Material Adverse Change, but excluding, in any case, any customer contracts. For the avoidance of doubt, “Material Contract”
includes any Manufacturing Agreement. 
 “Medicaid” means, collectively, the health care assistance program established by
Title XIX of the SSA (42 U.S.C. 1396 et seq.) and any statutes succeeding thereto, and all laws, rules, regulations, orders or requirements pertaining to such program, including (a) all federal statutes affecting such program; (b) all
state statutes and plans for medical assistance enacted in connection with such program and federal rules and regulations promulgated in connection with such program; and (c) all applicable provisions of all rules, regulations, orders and
administrative, reimbursement, and requirements of all Government Authorities promulgated in connection with such program, in each case as the same may be amended, supplemented or otherwise modified from time to time. 

“Medicare” means, collectively, the health insurance program for the aged and disabled established by Title XVIII of the SSA
(42 U.S.C. 1395 et seq.) and any statutes succeeding thereto, and all laws, rules, regulations or orders pertaining to such program including (a) all federal statutes (whether set forth in Title XVIII of the SSA or elsewhere) affecting such
program; and (b) all applicable provisions of all rules, regulations, orders and administrative, reimbursement and requirements of all governmental authorities promulgated in connection with such program, in each case as the same may be
amended, supplemented or otherwise modified from time to time. 
 “Money Laundering Laws” is defined in
Section 4.18(b). 
 “Mortgage ” means any deed of trust, leasehold deed of trust, mortgage,
leasehold mortgage, deed to secure debt, leasehold deed to secure debt or other document creating a Lien on real estate or any interest in real estate. 

“Multiemployer Plan” means a multiemployer plan within the meaning of Section 4001(a)(3) or Section 3(37) of ERISA
(a) to which Borrower or its Subsidiaries or their respective ERISA Affiliates is then making or accruing an obligation to make contributions; (b) to which Borrower or its Subsidiaries or their respective ERISA Affiliates has within the
preceding five (5) plan years made contributions; or (c) with respect to which Borrower or its Subsidiaries could incur material liability. 

“Net Sales” means, with respect to any period and solely with respect to sales of Products, the line item “product
sales” (which includes a reduction for product sales allowances) of Borrower and its Subsidiaries for the prior twelve (12) months, determined consistent with past practice on a consolidated basis in accordance with Applicable Accounting
Standards. 
 “Obligations” means, collectively, the Credit Parties’ obligations to pay when due any and all debts,
principal, interest, Lender Expenses, the Additional Consideration, the Make whole Amount, the Prepayment Premium, and other fees, expenses, indemnities and amounts any Credit Party owes Lender now or later, under this Agreement or any other Loan
Document, including interest accruing after Insolvency Proceedings begin (whether or not allowed) and debts, liabilities, or obligations of Borrower assigned to Lender, and to perform Borrower’s duties under the Loan Documents. 

“OFAC” is defined in Section 4.18(c). 

  
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 “OFAC Lists” means, collectively, the Specially Designated Nationals and
Blocked Persons List maintained by OFAC pursuant to Executive Order No. 13224, 66 Fed. Reg. 49079 (Sept. 25, 2001) or any other list of terrorists or other restricted Persons maintained pursuant to any of the rules and regulations of OFAC or
pursuant to any other applicable Executive Orders. 
 “Operating Documents” means, collectively with respect to any Person
such Person’s formation documents as certified with the Secretary of State or other applicable Governmental Authority of such Person’s jurisdiction of formation on a date that is no earlier than thirty (30) days prior to the date on
which such documents are due to be delivered under this Agreement and, (a) if such Person is a corporation, its bylaws (or similar organizational regulations) in current form, (b) if such Person is a limited liability company, its limited
liability company agreement (or similar Contract), and (c) if such Person is a partnership, its partnership agreement (or similar Contract), in each case, with all current amendments, restatements, supplements or modifications thereto. 

“ordinary course of business” means, in respect of any transaction involving any Person, the ordinary course of such
Person’s business, undertaken by such Person in good faith and not for purposes of evading any covenant, prepayment obligation or restriction in any Loan Document. 

“Other Connection Taxes” means, with respect to Lender, Taxes imposed as a result of a present or former connection
(including present or former connection of its agents) between such Lender and the jurisdiction imposing such Tax (other than connections arising solely from Lender having executed, delivered, become a party to, performed its obligations under,
received payments under, received or perfected a security interest under, engaged in any other transaction pursuant to or enforced any Loan Document). 

“Other Taxes” means all present or future stamp, court or documentary, intangible, recording, filing, sales, transfer,
excise, mortgage or property Taxes, charges or similar levies or similar Taxes that arise from any payment made hereunder, from the execution, delivery, performance, enforcement or registration of, from the receipt or perfection of a security
interest under, or otherwise with respect to, any Loan Document, except any such Taxes that are Other Connection Taxes imposed with respect to an assignment. 

“Patent Licenses” means (a) any Contract providing for the grant by or to a Person of any right to manufacture, use or
sell any invention covered by a Patent, together with the goodwill associated therewith, all registrations and recordings thereof, and all applications in connection therewith, whether in the United States Patent and Trademark Office or in any
similar office or agency of the United States, any State thereof or any other country, multinational body or any political subdivision thereof (and all related IP Ancillary Rights) and (b) all renewals thereof. 

“Patents” means all patents, patent applications including any improvements, continuations, continuations-in-part, divisions, provisionals or any substitute applications, any patent issued based upon any of the foregoing patent applications, any reissue, reexamination, renewal or patent term
extension or adjustment (including any supplementary protection certificate) of any such patent, and any confirmation patent or registration patent or patent of addition based on any such patent. 

“Patriot Act” is defined in Section 3.1(k). 

“Payment/Advance Form” means that certain form attached hereto as Exhibit A. 

“Payment Date” means the last day of each calendar quarter. 

“Perfection Certificate” is defined in Section 4.5. 

“Permitted Acquisition” means any Acquisition, so long as: 

(a) no Default or Event of Default shall have occurred and be continuing or would result from the consummation of the proposed Acquisition;

  
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 (b) the assets being acquired or licensed, or the Person whose Equity Interests are being
acquired, are useful in or engaged in, as applicable, (i) the same or a related line of business as that then-conducted by Borrower or its Subsidiaries or (ii) a line of business that is ancillary to and in furtherance of a line of
business as that then-conducted by Borrower or its Subsidiaries; 
 (c) in the case of an Asset Acquisition, the subject assets are being
acquired or licensed by Borrower or a Subsidiary of Borrower, and the applicable Person shall have executed and delivered or authorized, as applicable, any and all security agreements, financing statements, fixture filings, and other Contracts or
documentation required pursuant to Sections 5.14 and 5.15 in order to include the newly acquired or licensed assets within the Collateral; 

(d) in the case of a Stock Acquisition, (i) the subject Equity Interests are being acquired in such Acquisition directly by a Credit Party
and (ii) the relevant Credit Party shall have complied with its obligations under Section 5.14 within the time periods specified therein; 

(e) any Indebtedness or Liens assumed in connection with such Acquisition are otherwise permitted under Section 6.4
or 6.5, respectively; 
 (f) such Acquisition shall be consensual and shall have been approved by the Board of Directors of the Person
whose Equity Interests or assets are proposed to be acquired and shall not have been preceded by an unsolicited tender offer for such Equity Interests by, or proxy contest initiated by, Borrower or any of its Subsidiaries; 

(g) Borrower shall have delivered to Lender (i) to the extent prepared, projections for the Person whose Equity Interests or assets or
properties are proposed to be acquired or, in the case of an applicable co-promotion or co-marketing arrangement, for the product that is the subject of such
arrangement, (ii) for any Acquisition for consideration in excess of $5,000,000, updated pro forma projections for Borrower and its Subsidiaries evidencing compliance on a pro forma basis with Section 5.12 and
Section 6.17 for the twelve (12) calendar months following the date of such Acquisition (on a quarter-by-quarter basis) and (iii) for
any Acquisition, a Perfection Certificate, updated solely with respect to such Acquisition if the kind or nature of the Equity Interests, assets or properties which are the subject of such Acquisition is such as would require Lender to take any
steps to establish, maintain, protect or enforce a first priority security interest therein and Lien thereon securing the Obligations; and 

(h) at least five (5) Business Days prior to the proposed date of consummation of such Acquisition, Borrower shall have delivered to
Lender a certificate of a Responsible Officer of Borrower certifying that (i) such Acquisition complies with this definition of “Permitted Acquisition” (which shall have attached thereto reasonably detailed backup data and
calculations showing such compliance) and (ii) such Acquisition could not reasonably be expected to result in a Material Adverse Change. 

“Permitted Hedging Agreement” means any currency agreement or other Contract or arrangement designed solely to protect a
Person against fluctuations in currency exchange rates, and any confirmation executed in connection with any such agreement, Contract, or arrangement, in each case, entered into by Borrower or any of its Subsidiaries solely to hedge or mitigate the
risks of foreign exchange rate fluctuations and not for any speculative or other purposes; provided that such agreement, Contract or arrangement complies in all respects with the hedging policies or guidelines as are approved by the Board of
Directors and as are approved by Lender (such approval not to be unreasonably withheld, delayed or conditioned). 
 “Permitted
Indebtedness” means: 
 (a) Credit Parties’ Indebtedness to Lender under this Agreement and the other Loan Documents; 

(b) Indebtedness existing on the Tranche A Closing Date and shown on Schedule 13.1 of the Disclosure Letter; 

  
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 (c) Indebtedness consisting of Contingent Obligations set forth in clause (a) of
the definition of “Contingent Obligation” (i) of a Credit Party of Permitted Indebtedness of another Credit Party, (ii) of a Subsidiary of Borrower which is not a Credit Party of Permitted Indebtedness of another Subsidiary of
Borrower which is not a Credit Party, (iii) of a Subsidiary of Borrower which is not a Credit Party of Permitted Indebtedness of a Credit Party and (iv) of a Credit Party of Permitted Indebtedness and
non-debt obligations of a Subsidiary of Borrower which is not a Credit Party in an amount not to exceed $500,000 in any fiscal year; 

(d) Indebtedness consisting of Contingent Obligations (i) set forth in clause (b) of the definition of “Contingent
Obligation” and (ii) set forth in clause (c) of the definition of “Contingent Obligation” in connection with any Permitted Acquisition; 

(e) Indebtedness of Borrower in the form of a revolving loan facility with a maximum aggregate credit line of no more than $10,000,000 at any
and all times; provided, however, that Consolidated EBITDA for each of the two (2) consecutive fiscal quarters immediately prior to the initial incurrence of any Indebtedness was no less than $0.00 (excluding extraordinary or non-recurring items); provided, further, that Consolidated EBITDA for each of the two (2) consecutive fiscal quarters immediately prior to any subsequent draw down of any Indebtedness was no less
than $0.00 (excluding extraordinary or non-recurring items); provided, further, that the proceeds of such Indebtedness shall not be used to fund, in whole or in part, any Acquisition;
provided, further, that such Indebtedness is secured on a first-priority basis by Liens on Inventory, accounts receivable, cash, supporting obligations and all proceeds of the foregoing to secure the obligations under such facility
shall be senior in rank, order of priority and enforcement to the security interests and Liens of Lender in any such assets to secure the Obligations at all times until all of the obligations under such facility have been paid, performed or
discharged in full and Borrower has no further right to obtain any extension of credit thereunder, pursuant to a subordination, intercreditor or other similar Contract among Lender, Borrower and the lender under such facility, in form and substance
reasonably satisfactory to Lender and the lender under such facility; 
 (f) Indebtedness of any Person that becomes a Subsidiary (or of any
Person not previously a Subsidiary that is merged or consolidated with or into a Subsidiary in a transaction permitted hereunder) of Borrower after the Tranche A Closing Date, or Indebtedness of any Person that is assumed after the Tranche A Closing
Date by any Subsidiary in connection with an acquisition of assets by such Subsidiary, in either case, in a Permitted Acquisition; provided that (i) such Indebtedness exists at the time such Person becomes a Subsidiary (or such merger or
consolidation) or such assets are acquired and is not created in contemplation of or in connection with such Person becoming a Subsidiary (or such merger or consolidation) or such assets being acquired or such Indebtedness arises as a result of an earn-out or similar arrangement, (ii) either: (A) no Subsidiary of Borrower (other than a Subsidiary without significant assets formed in order to effect such acquisition, including by way of a merger) or
Borrower shall guarantee or otherwise become liable for the payment of such Indebtedness or (B) if any other Subsidiary of Borrower becomes liable for or guarantees such Indebtedness, its liability or guarantee with respect to such Indebtedness
shall at all times be subordinated to its obligations hereunder, if any, pursuant to a subordination, intercreditor or other similar Contract in form and substance reasonably satisfactory to Lender and (iii) the creation, incurrence, assumption or
guarantee of, or the liability with respect to, such Indebtedness would not otherwise result in a Default or Event of Default; 
 (g) secured
and unsecured business credit card Indebtedness in an outstanding principal amount not to exceed at any time $1,000,000 in the aggregate; 

(h) unsecured intercompany Indebtedness permitted under clauses (m), (o) and (t) under the definition of
“Permitted Investments”; 
 (i) Indebtedness owed to (including obligations in respect of letters of credit or bank guarantees or
similar instruments for the benefit of) any Person providing workers’ compensation, health, disability or other employee benefits or property, casualty or liability insurance to Borrower or any of its Subsidiaries, pursuant to reimbursement or
indemnification obligations to such Person, in each case, in the ordinary course of business; 
 (j) Indebtedness in respect of performance
bonds, bid bonds, appeal bonds, surety bonds and completion guarantees and similar obligations arising in the ordinary course of business; 

  
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 (k) Indebtedness in respect of netting services or overdraft protection in connection with
deposit or securities accounts in the ordinary course of business; 
 (l) Indebtedness consisting of the financing of insurance premiums in
the ordinary course of business; 
 (m) Indebtedness not to exceed $1,000,000 in the aggregate at any time outstanding, consisting of capital
lease obligations or secured by Liens permitted by clause (d) of the definition of “Permitted Liens”; 
 (n)
Indebtedness arising in connection with endorsement of instruments for deposit in the ordinary course of business; 
 (o) Permitted Hedging
Agreements; 
 (p) purchase price adjustments, indemnity payments and earn-out obligations in
connection with any Permitted Acquisition; 
 (q) obligations in respect of Consulting Royalties; 

(r) Indebtedness of Subsidiaries owed to Credit Parties and their Subsidiaries in connection with the sale of Inventory in the ordinary course
of business; 
 (s) other Indebtedness in an aggregate amount not to exceed $500,000; and 

(t) subject to the proviso immediately below, extensions, refinancings, modifications, amendments and restatements of any items of Permitted
Indebtedness in clauses (a) through (s) above; provided that the principal amount thereof is not increased other than by any reasonable premium or other reasonable amount paid and fees and expenses reasonably incurred in
connection with the same and the terms thereof are not modified to shorten the maturity thereof. 
 Notwithstanding the foregoing,
“Permitted Indebtedness” shall not include any (x) Indebtedness incurred by Borrower or any of its Subsidiaries upon the conversion or exchange of any Disqualified Equity Interests which are not issued and outstanding as of the
Effective Date and shown on Schedule 13.2 of the Disclosure Letter and (y) Hedging Agreements other than Permitted Hedging Agreements. 

“Permitted Investments” means: 

(a) Investments (including Investments in Subsidiaries) existing on the Tranche A Closing Date and shown on Schedule 13.1 of the Disclosure
Letter, and any extensions, renewals or reinvestments thereof; 
 (b) Investments (i) consisting of cash and Cash Equivalents and
(ii) permitted by the proposed amendment to the investment policy provided to Lender and expected to be adopted immediately after Borrower becomes a Public Reporting Company; provided, however, that, for purposes of measuring
compliance with any provision of Section 5.12 or Section 6, “Cash Equivalents” shall only include Investments permitted by Borrower’s investment policy effective March 1, 2016
and previously made available to Lender; 
 (c) Investments consisting of the endorsement of negotiable instruments for deposit or collection
or similar transactions in the ordinary course of business; 
 (d) subject to Section 5.6, Investments consisting of deposit
accounts or securities accounts; 
 (e) Investments by Borrower or any of its Subsidiaries pursuant to a Permitted License; 

(f) Investments in connection with Permitted Transfers; 

  
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 (g) Investments consisting of (i) travel advances and employee relocation loans and
other employee advances in the ordinary course of business and (ii) loans to employees, officers or directors relating to the purchase of equity securities of Borrower pursuant to employee stock purchase plans or Contracts approved by
Borrower’s Board of Directors, so long as the aggregate amount of all such loans does not exceed $500,000 in the aggregate; 
 (h)
Investments (including debt obligations) received in connection with the bankruptcy or reorganization of customers or suppliers and in settlement of delinquent obligations of, and other disputes with, customers or suppliers arising in the ordinary
course of business; 
 (i) Investments consisting of notes receivable of, or prepaid royalties and other credit extensions, to customers and
suppliers who are not Affiliates, in the ordinary course of business; provided that this clause (i) shall not apply to Investments of any Credit Party in any of its Subsidiaries; 

(j) joint ventures or strategic alliances consisting of the non-exclusive licensing of technology, the
development of technology or the providing of technical support; provided that any cash investments by Borrower and its Subsidiaries do not exceed $500,000 in the aggregate in any fiscal year; 

(k) any Permitted Acquisitions and Investments required in connection with a Permitted Acquisition (including the formation of any Subsidiary
for the purpose of effectuating such Permitted Acquisition, the capitalization of such Subsidiary whether by capital contribution or intercompany loans, in each case, to the extent permitted by the terms of this Agreement, related Investments in
Subsidiaries necessary to consummate such Permitted Acquisition, and the receipt of any non-cash consideration in a Permitted Acquisition); 

(l) Investments constituting the formation of any Subsidiary for the purpose of consummating a merger or acquisition transaction permitted by
Section 6.3(a)(i) through (v) hereof; provided that such merger or acquisition transaction is otherwise a Permitted Investment; 

(m) Investments of any Person that (i) becomes a Subsidiary of Borrower (or of any Person not previously a Subsidiary of Borrower that is
merged or consolidated with or into a Subsidiary of Borrower in a transaction permitted hereunder) after the Tranche A Closing Date, or (ii) are assumed after the Tranche A Closing Date by any Subsidiary of Borrower in connection with an
acquisition of assets from such Person by such Subsidiary, in either case, in a Permitted Acquisition; provided that, in each case, any such Investment (x) exists at the time such Person becomes a Subsidiary of Borrower (or is merged or
consolidated with or into a Subsidiary of Borrower) or such assets are acquired, (y) was not made in contemplation of or in connection with such Person becoming a Subsidiary of Borrower (or merging or consolidating with or into a Subsidiary of
Borrower) or such acquisition of assets, and (z) such Investment would not otherwise result in a Default or Event of Default; 
 (n)
Investments arising as a result of the licensing of Intellectual Property in the ordinary course of business; 
 (o) Investments by
(i) any Credit Party in or to any other Credit Party, (ii) any Subsidiary of Borrower which is not a Credit Party in or to another Subsidiary of Borrower which is not a Credit Party, (iii) any Subsidiary of Borrower which is not a
Credit Party in or to any Credit Party and (iv) any Credit Party or any Subsidiary of a Credit Party to any Subsidiary of a Credit Party which is not a Credit Party in an amount not to exceed $2,000,000 per fiscal year; 

(p) Investments arising out of Transfers of Inventory by Borrower to Subsidiaries that are not Credit Parties pursuant to transfer pricing
arrangements in the ordinary course of business (and any related intercompany balances and any capitalization of such balances); 
 (q)
Investments arising out of the receipt of non-cash consideration for any Permitted Transfer; 
 (r)
Permitted Hedging Agreements; 

  
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 (s) without limiting the generality of clause (k) above, Investments consisting
of earnest money deposits required in connection with a Permitted Acquisition or other acquisition of properties or assets not prohibited hereunder; 

(t) Investments consisting of Acquisitions from third parties of Inventory, Equipment, office supplies, software and other similar assets in
the ordinary course of business; and 
 (u) other Investments not otherwise permitted under Section 6.8 in an
aggregate amount (valued at the time of the making thereof) not to exceed $500,000 at any time; 
 provided, however, that
none of the foregoing Investments shall be a “Permitted Investment” if any Indebtedness or Liens assumed in connection with such Investment are not otherwise permitted under Section 6.4 or 6.5,
respectively. 
 Notwithstanding the foregoing, “Permitted Investments” shall not include any Hedging Agreements other than
Permitted Hedging Agreements. 
 “Permitted Licenses” means: (a) a
non-exclusive or an exclusive as to geography other than the United States license of (or covenant not to sue with respect to) Intellectual Property or grant of development, manufacture, distribution, co-promotion or similar commercial rights to third parties; (b) subject to prior satisfaction of the requirements set forth in the following sentence, a non-exclusive or
an exclusive as to geography within the United States license of Intellectual Property or grant of development, manufacture, distribution, co-promotion or similar commercial rights to third parties; (c) non-exclusive licensing of (or granting of a covenant not to sue with respect to) technology or Intellectual Property, granting of development, manufacture, distribution,
co-promotion or similar commercial rights, the development of technology or the providing of technical support; (d) a non-exclusive or an exclusive grant of
manufacturing and distribution licenses to third parties in the ordinary course of business; and (e) intercompany licenses or other similar arrangements among the Credit Parties and their Subsidiaries; provided, however, that the
licenses or similar arrangements described in this clause (e) by any Credit Party to any Subsidiary that is not a Credit Party shall not permit any non-exclusive or exclusive as to geography within
the United States license of (or covenant not to sue with respect to) Intellectual Property (including any out-licenses) or grant of development, manufacture, distribution,
co-promotion or similar commercial rights (including the right to Commercialize Products) and shall only permit an exclusive as to geography other than the United States license of Intellectual Property if
such Credit Party retains all rights to such Intellectual Property other than those rights that are the subject of such license. Notwithstanding the foregoing, any license or other arrangement described in clause (b) above shall not
constitute a Permitted License hereunder unless and until (i) Borrower shall have given written notice of such proposed license or other arrangement to Lender, which notice shall (A) identify the parties to such proposed license or other
arrangement, (B) include a description of the material terms and conditions of such proposed license or other arrangement and (C) include copies of any and all Contracts relating to such proposed license or other arrangement,
(ii) Lender shall have given its written consent to such proposed license or other arrangement; provided that, in the event Lender does not deliver in writing its rejection of such proposed license or other arrangement within ten
(10) Business Days after the effective date of delivery of the notice from Borrower contemplated in sub-clause (i) above, then Lender shall be deemed to have waived its right to reject such
proposed license or other arrangement, and Borrower or its Subsidiary that is a party to such proposed license or other arrangement shall be permitted to enter into such proposed license or other arrangement, unless any of the terms or conditions
thereof have changed in any material respect from the terms set forth in the materials provided to Lender pursuant to sub-clause (i) above, in which event Lender’s right to consent to such
proposed license or other arrangement shall be deemed to be revived and such proposed license or other arrangement shall not constitute a Permitted License unless and until Borrower delivers a new notice to Lender in accordance with sub-clause (i) above and the requirements of sub-clause (ii) above has been satisfied as to such proposed license or other arrangement (as so amended or
modified). Notwithstanding the foregoing, “Permitted Licenses” shall not include any Excluded Licenses entered into after the Tranche A Closing Date unless first consented to in writing by Lender. 

“Permitted Liens” means: 

(a) Liens existing on the Tranche A Closing Date and shown on the Perfection Certificate or arising under this Agreement and the other Loan
Documents; 

  
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 (b) Liens existing on the Tranche A Closing Date and shown on Schedule 13.1 of the
Disclosure Letter; 
 (c) Liens for Taxes, fees, assessments or other government charges or levies, either (i) not due and payable or
(ii) being contested in good faith and for which such Credit Party maintains adequate reserves on its Books; provided that no notice of any such Lien has been filed or recorded; 

(d) (i) Liens on any property acquired or held by any Credit Party or any Subsidiary of any Credit Party incurred or assumed for the
purpose of financing (or refinancing) all or any part of the cost of acquiring, repairing, improving or constructing such property and (ii) Liens securing capital lease obligations, in each case, permitted under clause (m) of the
definition of “Permitted Indebtedness”; 
 (e) Permitted Licenses and Liens incurred pursuant to Permitted Licenses, and the
licenses or grants described in Section 6.1(e); 
 (f) Liens of carriers, warehousemen, suppliers, landlords,
mechanics, materialmen, repairmen or other Persons that are possessory in nature arising in the ordinary course of business, so long as no such Lien secures liabilities in an amount in excess of $250,000, individually, or $500,000, in the aggregate
for all such Liens and, in each case, such liabilities are not delinquent or remain payable without penalty or are being contested in good faith and by appropriate proceedings diligently conducted, and for which such Credit Party maintains adequate
reserves on its Books; 
 (g) Liens to secure payment of workers’ compensation, unemployment insurance,
old-age pensions, social security and other like obligations incurred in the ordinary course of business (other than Liens imposed by ERISA); 

(h) Liens arising from attachments or judgments, orders, or decrees in circumstances not constituting an Event of Default under either
Section 7.4 or 7.7; 
 (i) subject to Section 5.6, Liens in favor of other financial
institutions arising in connection with deposit or securities accounts held at such institutions; provided that such Liens relate solely to obligations for administrative and other banking fees and expenses (but not Indebtedness) incurred in
the ordinary course of business in connection with the maintenance of such accounts; 
 (j) subject to
Section 6.2(c), statutory or common law Liens of landlords; 
 (k) leases or subleases of real property granted in
the ordinary course of Borrower’s business consistent with past practice (or, if referring to another Person, in the ordinary course of such Person’s business), and leases, subleases, nonexclusive licenses or sublicenses of personal
property (other than Intellectual Property) granted in the ordinary course of Borrower’s business consistent with past practice (or, if referring to another Person, in the ordinary course of such Person’s business), in each case, if such
lease, sublease, license or sublicense does not prohibit granting Lender a security interest therein; 
 (l) Liens incurred or deposits made
to secure the performance of tenders, bids, leases, statutory or regulatory obligations, surety and appeal bonds, government contracts, performance and return-of-money
bonds, and other obligations of like nature, in each case, in the ordinary course of business; 
 (m) Liens on the properties or assets of a
Subsidiary which is not a Credit Party securing Indebtedness of such Subsidiary permitted hereunder; 
 (n) Liens securing Indebtedness
permitted under clauses (d)(i), (e), (f), (g), (i), (j), (k), (l), (m), (n), (p) and (t) of the definition of “Permitted Indebtedness” (as they relate
to Indebtedness permitted under clauses (d)(i), (e), (f), (g), (i), (j), (k), (l), (m), (n), (p) and (t) of such definition); provided that, in the case
of Liens securing Indebtedness permitted pursuant to clause (d)(i) of the definition of “Permitted Indebtedness,” such Liens are limited to Liens on cash and Cash Equivalents in an amount not to exceed 110% of the face amount of the
applicable letter of credit; 

  
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 (o) Liens on earnest money deposits in connection with any Permitted Acquisition or other
acquisition of properties or assets not prohibited hereunder; 
 (p) any interest or title of a lessor or sublessor under any lease permitted
by this Agreement; provided that such interest or title is subordinate to the interest of the Secured Parties; 
 (q) easements, rights-of-way, zoning and other restrictions, minor defects or other irregularities in title and other similar encumbrances incurred in the ordinary course of business which
are not substantial in amount and which do not materially detract from the value of the property subject thereto or materially interfere with the ordinary conduct of the businesses of any Credit Party or any Subsidiary of any Credit Party; 

(r) Liens arising out of a conditional sale, title retention, consignment or similar arrangements for the sale of Product entered into by
Borrower or any Subsidiary of Borrower in the ordinary course of business; 
 (s) Liens on cash and Cash Equivalents to secure obligations
under Permitted Hedging Agreements; and 
 (t) Liens incurred in the extension, renewal or refinancing of the indebtedness secured by Liens
described in clauses (a) through (s), but any extension, renewal or replacement Lien must be limited to the properties or assets encumbered by the existing Lien (and any additions, accessions, parts, improvements and attachments
thereto and the proceeds thereof) and the principal amount of the indebtedness may not increase other than by any reasonable premium or other reasonable amount paid and fees and expenses reasonably incurred in connection with the same;
provided, however, that, to the extent any of the foregoing Liens secure Indebtedness of a Credit Party, such Liens shall constitute Permitted Liens only if and to the extent that such Indebtedness constitutes Permitted Indebtedness.

 “Permitted Transfers” is defined in Section 6.1. 

“Person” means any individual, sole proprietorship, partnership, limited liability company, joint venture, company, trust,
unincorporated organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or government agency. 

“Plan” means any employee pension benefit plan (other than a Multiemployer Plan) subject to the provisions of Title IV of
ERISA or Section 412 of the IRC or Section 302 of ERISA which is maintained or contributed to by Borrower or its Subsidiaries or their respective ERISA Affiliates or with respect to which Borrower or its Subsidiaries are subject to
liability (including under Section 4069 of ERISA). 
 “Preferred Stock” means, as applied to the Equity Interests of
any Person, the Equity Interests of any class or classes (however designated) that is preferred with respect to the payment of dividends, or as to the distribution of assets upon any voluntary or involuntary liquidation or dissolution of such
Person, over shares of Equity Interests of any other class of such Person. 
 “Prepayment Premium” means, with respect to
any prepayment of the Term Loans by Borrower pursuant to Section 2.2(c), an amount equal to the product of the amount of such prepayment (including, for the avoidance of doubt, all principal and accrued and unpaid interest
thereon), multiplied by: 
 (i) if such prepayment occurs prior to the four (4) year anniversary of the Tranche A
Closing Date, 0.02; and 
 (ii) if such prepayment occurs on or after the four (4) year anniversary of the Tranche A
Closing Date and prior to the Term Loan Maturity Date, 0.01. 
 “Private Third Party Payor Programs” means all third party
payor programs in which any Credit Party or its Subsidiaries participates, including Managed Care Plans, or any other private insurance programs, whether domestic or foreign, but excluding all Governmental Payor Programs. 

  
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 “Product” means, collectively, the iFuse ImplantTM, the iFuse-3DTM Implant and the iFuse Neuromonitoring Kit (or any successor products thereto). 

“Product IP” means any and all Current Company IP relating to the Products. 

“Public Reporting Company” means an issuer generally subject to the reporting requirements of the Securities and
Exchange Act of 1934. 
 “Register” is defined in Section 2.8(a). 

“Registered Organization” means any “registered organization” as defined in the Code with such additions to such
term as may hereafter be made. 
 “Regulatory Agency” means a Governmental Authority with responsibility for the approval
of the marketing and sale of pharmaceutical, biologic or medical devices or other regulation of pharmaceutical, biologic or medical devices. 

“Regulatory Approval” means all approvals (including where applicable, pricing and reimbursement approval and schedule
classifications), licenses (including product or establishment licenses), registrations, clearances or authorizations of any Regulatory Agency necessary for the development, Manufacture, production, use, import, export, transport or sale of any
Product. 
 “Release” means any release, spill, emission, leaking, pumping, pouring, injection, escaping, deposit,
disposal, discharge, dispersal, dumping, leaching or migration of any Hazardous Material into the indoor or outdoor environment (including the abandonment or disposal of any barrels, containers or other closed receptacles containing any Hazardous
Material), including the movement of any Hazardous Material through the air, soil, surface water or groundwater. 
 “Requirements of
Law ” means, as to any Person, the organizational or governing documents of such Person, and any law (statutory or common), treaty, order, policy, rule or regulation or determination of an arbitrator or a court or other Governmental
Authority (including Health Care Laws, FDA Laws and all applicable statutes, rules, regulations, standards, policies and orders administered or issued by any foreign Governmental Authority), in each case, applicable to or binding upon such Person or
any of its properties or assets or to which such Person or any of its properties or assets is subject. 
 “Responsible
Officer” means, with respect to any Credit Party or its Subsidiaries, any of the Chief Executive Officer, President, Chief Financial Officer and Controller of such Credit Party. 

“Restricted License” means any Current Company IP Agreement that prohibits or otherwise restricts a Credit Party from
granting a security interest in such Credit Party’s interest in such Current Company IP Agreement in a manner enforceable under applicable law. 

“SEC” shall mean the Securities and Exchange Commission and any analogous Governmental Authority. 

“Secured Parties” means Lender, each other Indemnified Person and each other holder of any Obligation of a Credit Party. 

“Securities Account” means any “securities account” as defined in the Code. 

“Security Agreement” means the Guaranty and Security Agreement, dated as of the Tranche A Closing Date, by and among the
Credit Parties and Lender, as such may be amended, restated, supplemented or otherwise modified from time to time. 

  
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 “Solvent” means, with respect to any Person as of any date of
determination, that, as of such date, (a) the value of the assets of such Person (both at fair value and present fair saleable value) is greater than the total amount of liabilities (including contingent and unliquidated liabilities) of such
Person, (b) such Person is able to pay all liabilities of such Person as such liabilities mature and (c) such Person does not have unreasonably small capital. In computing the amount of contingent or unliquidated liabilities at any time,
such liabilities shall be computed at the amount that, in light of all the facts and circumstances existing at such time, represents the amount that can reasonably be expected to become an actual or matured liability. 

“Specified Disputes” is defined in Section 4.5(j). 

“Specified Financial Covenants” is defined in Section 6.17(c). 

“SSA” means the Social Security Act of 1935, codified at Title 42, Chapter 7, of the United States Code. 

“Stock Acquisition” means the purchase or other acquisition by Borrower or any of its Subsidiaries of all of the Equity
Interests (by merger, stock purchase or otherwise) of any other Person. 
 “Subordinated Debt” means, collectively,
unsecured Indebtedness incurred by any Credit Party or any Subsidiary thereof (including any Indebtedness permitted in connection with any Permitted Acquisition) that (a) is subordinated in right of payment to the Obligations pursuant to a
subordination, intercreditor or other similar Contract that is in form and substance satisfactory to Lender (which Contract shall include turnover provisions that are satisfactory to Lender), (b) is not subject to scheduled amortization, redemption
(mandatory or voluntary), sinking fund or similar payment and does not have a final maturity, in each case, before the date that is six (6) months after the Term Loan Maturity Date, (c) does not include any covenants or any agreements
that, individually or taken as a whole, are more restrictive or onerous on any Credit Party in any material respect than any comparable covenants in this Agreement and (d) does not provide or otherwise include provisions having the effect of
providing that a default or event of default (or the equivalent thereof, however described) under or in respect of such Indebtedness shall exist, or such Indebtedness shall otherwise become due prior to its scheduled maturity or the holder or
holders thereof or any trustee or agent on its or their behalf shall be permitted (with or without the giving of notice, the lapse of time or both) to cause any such Indebtedness to become due, or to require the prepayment, repurchase, redemption or
defeasance thereof, prior to its scheduled maturity, in any such case upon the occurrence of a Default or Event of Default unless and until the Obligations have been declared, or have otherwise automatically become, immediately due and payable
pursuant to Section 8.1(a). 
 “Subsidiary ” means, with respect to any Person, a corporation,
partnership, limited liability company or other entity of which shares of stock or other ownership interests having ordinary voting power (other than stock or such other ownership interests having such power only by reason of the happening of a
contingency) to elect a majority of the Board of Directors of such corporation, partnership or other entity are at the time owned, or the management of which is otherwise controlled, directly or indirectly through one or more intermediaries, or
both, by such Person. Unless the context otherwise requires, each reference to a Subsidiary herein shall be a reference to a direct or indirect Subsidiary of a Credit Party. 

“Tax” means any United States federal, state, local or non-United States income, gross receipts, license, payroll,
employment, occupation, premium, profits, withholding, franchise, alternative minimum, sales, use, transfer, value added, excise, stamp, customs, real property, personal property, escheat, capital stock, social security, unemployment or other
similar charge or tax of any kind whatsoever, including any interest, penalties or additions to tax in respect of the foregoing, whether disputed or not. 

“Term Loan” means each of the Tranche A Loan and the Tranche B Loan, as applicable, and “Term Loans”
means, collectively, the Tranche A Loan and the Tranche B Loan. 
 “Term Loan Maturity Date” means the five-year
anniversary of the Tranche A Closing Date. 
 “Term Loan Note” means each of the Tranche A Note and the Tranche B Note, as
applicable, and “Term Loan Notes” means, collectively, the Tranche A Note and the Tranche B Note. 

  
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 “Territory” means the United States and all other countries in which any
Product has been Commercialized, or in which any attempt to Commercialize any Product has occurred (such as submission of applications to Governmental Authorities). 

“Third Party IP” is defined in Section 4.5(n). 

“Trademark License” means any Contract providing for the grant by or to a Person of any right to use any Trademark. 

“Trademarks” means (a) all trademarks, trade names, corporate names, company names, business names, fictitious business
names, service marks, elements of package or trade dress of goods or services, logos and other source or business identifiers, together with the goodwill associated therewith, all registrations and recordings thereof, and all applications in
connection therewith, whether in the United States Patent and Trademark Office or in any similar office or agency of the United States, any State thereof or any other country, multinational body or any political subdivision thereof (and all related
IP Ancillary Rights) and (b) all renewals thereof. 
 “Tranche A Closing Date” means the earlier to occur of
(a) the date that is ten (10) Business Days following the Effective Date and (b) October 27, 2017. 
 “Tranche A
Loan” is defined in Section 2.2(a)(i). 
 “Tranche A Loan Amount” is defined in
Section 2.2(a)(i). 
 “Tranche A Note” means a promissory note in substantially the form attached
hereto as Exhibit C-1, as it may be amended, restated, supplemented or otherwise modified from time to time. 

“Tranche B Closing Date” means the date on which the Tranche B Loan is advanced by Lender, which, subject to the satisfaction
of the conditions precedent to the Tranche B Loan set forth in Section 3.2 and Section 3.3, shall be after the Tranche A Closing Date and on or prior to January 31, 2019. 

“Tranche B Note” means a promissory note in substantially the form attached hereto as Exhibit C-2, as it may be amended, restated, supplemented or otherwise modified from time to time. 

“Tranche B Loan” is defined in Section 2.2(a)(ii). 

“Tranche B Loan Amount” means (a) if Net Sales for the two fiscal quarters preceding the Tranche B Closing Date taken
together are greater than or equal to $28,500,000 but less than $33,000,000, $10,000,000; and (b) if Net Sales for the two fiscal quarters preceding the Tranche B Closing Date taken together are greater than or equal to $33,000,000, not less than
$10,000,000 and not greater than $20,000,000, as selected by Borrower in its sole discretion in the Payment/Advance Form. For the avoidance of doubt if Net Sales for the two fiscal quarters preceding the Tranche B Closing Date taken together are
less than $28,500,000, the Tranche B Loan Amount equals zero. 
 “Transfer” is defined in
Section 6.1. 
 “TRICARE” means, collectively, a program of medical benefits covering former and
active members of the uniformed services and certain of their dependents, financed and administered by the United States Departments of Defense, Health and Human Services and Transportation, and all laws applicable to such programs. 

“United States” or “U.S.” means the United States of America, its fifty (50) states, each territory
thereof and the District of Columbia, including American Samoa, Puerto Rico, the U.S. Virgin Islands, Guam, Northern Marianas, Johnson Atoll, Kingman Reef, Midway Islands, Navassa Island, Howland Island, Palmyra Atoll, Baker Island, Jarvis Island
and Wake Island. 

  
 74 

 “Vulture Fund” means any hedge fund or private equity fund that exclusively
buys distressed securities of commercial companies or sovereign nations and then uses various methods to gain a larger amount than the purchase price of such securities. 

“WHO” means the World Health Organization. 

“Wholly-Owned Subsidiary” means, with respect to any Person, a Subsidiary of such Person, all of the Equity Interests of
which (other than directors’ qualifying shares or nominee or other similar shares required pursuant to Requirements of Law) are owned by such Person or another Wholly-Owned Subsidiary of such Person. Unless the context otherwise requires, each
reference to a Wholly-Owned Subsidiary herein shall be a reference to a Wholly-Owned Subsidiary of a Credit Party. 
 “Withdrawal
Liability” means liability to a Multiemployer Plan as a result of a complete or partial withdrawal from such Multiemployer Plan, as such terms are defined in Part I of Subtitle E of Title IV of ERISA. 

[Signature page follows.] 
  

  
 75 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be executed as
of Effective Date. 
 SI-BONE, INC., 
 as Borrower 

 

	
	By /s/ Laura
Francis                                    
	Name: Laura Francis
	Title: Chief Financial Officer

 Signature Page to Loan Agreement 

 BIOPHARMA CREDIT INVESTMENTS IV SUB LP, 

as Lender 
 By: Pharmakon
Advisors, LP, 
 its Investment Manager 

By: Pharmakon Management I, LLC, 

its General Partner 
  

	
	By /s/ Pedro Gonzalez de Cosio                    
	Name: Pedro Gonzalez de Cosio
	Title: Managing Member

 Signature Page to Loan Agreement 

 

 EXHIBIT A – PAYMENT/ADVANCE FORM 

The undersigned, being the duly elected and
acting                     of SI-BONE, INC., a Delaware corporation (“Borrower”), does
hereby certify, solely in his/her capacity as an authorized officer of Borrower and not in his/her personal capacity, to BIOPHARMA CREDIT INVESTMENTS IV SUB LP (“Lender”) in connection with that certain Loan Agreement dated as of
October 13, 2017 by and among Borrower, Lender and the other parties thereto (the “Loan Agreement”; with other capitalized terms used below having the meanings ascribed thereto in the Loan Agreement) that, on the Tranche [A][B]
Closing Date: 
 1. [the amount of the Tranche B Loan shall be
$                        .]1 

2. the representations and warranties made by the Credit Parties in Section 4 of the Loan Agreement and in the other Loan Documents are
true and correct in all material respects, unless any such representation or warranty is stated to relate to a specific earlier date, in which case such representation or warranty shall be true and correct in all material respects as of such earlier
date (it being understood that any representation or warranty that is qualified as to “materiality,” “Material Adverse Change,” or similar language shall be true and correct in all respects on the Tranche [A][B] Closing Date or
as of such earlier date, as applicable); 
 3. no Default or an Event of Default has occurred since the [Effective Date]2 [Tranche A Closing Date]3 or is occurring as of the date hereof; 

4. each of the Credit Parties is in compliance with the covenants and requirements contained in Sections 5 and 6 of the Loan
Agreement; 
 5. all conditions referred to in Section 3 of the Loan Agreement to the making of the Term Loan to be
made on or about the date hereof have been satisfied or waived in writing by Lender; 
 6. no Material Adverse Change or Change in Control
has occurred; 
 7. the undersigned is a Responsible Officer; and 

8. the proceeds of the Term Loan shall be disbursed as set forth on Attachment A hereto. 

Dated:                         
                       , 201_ 

[signature page follows] 
  

 

1 To be included in Payment/Advance Form for Tranche B Loan only. 

2 To be included in Payment/Advance Form for Tranche A Loan only.  
 3 To be included in Payment/Advance Form for Tranche
B Loan only. 

	
	 SI-BONE, INC.,

as Borrower

	
	By                                      
                                   
	Name:                                     
                                    
	Title:                                     
                                    

 EXHIBIT B - COMPLIANCE CERTIFICATE 

TO:     BIOPHARMA CREDIT INVESTMENTS IV SUB LP 

FROM: SI-BONE, INC. 

The undersigned authorized officer of SI-BONE, INC., a Delaware corporation
(“Borrower”) hereby certifies, solely in his/her capacity as an authorized officer of Borrower and not in his/her personal capacity, that in accordance with the terms and conditions of the Loan Agreement (the “Loan
Agreement”) dated as of October 13, 2017 by and between Borrower and BioPharma Credit Investments IV Sub LP, a Cayman Islands limited partnership (“Lender”): 

(i) The Credit Parties are in complete compliance for the period ending _______________ with all required covenants except as noted below; [it
being understood and agreed that audited annual financial statements are due within one hundred eighty (180) days of the end of each fiscal year pursuant to Section 5.2(a)(i) of the Loan Agreement;]4 
 (ii) No Default or Event of Default has occurred and is continuing, except as noted
below; and 
 (iii) Each Credit Party, and each of its Subsidiaries, have timely filed all required Tax returns and reports or extensions
therefor, have timely paid all foreign, federal, state, and local Taxes, assessments, deposits and contributions owed by such Credit Party and each of its Subsidiaries, except as otherwise permitted pursuant to the terms of
Section 5.4 of the Loan Agreement. 
 Attached are the required documents, if any, supporting our certification(s).
The undersigned officer on behalf of Borrower further certifies that the attached financial statements are prepared in accordance with Applicable Accounting Standards and are consistently applied from one period to the next except as explained in an
accompanying letter or footnotes and except, in the case of unaudited financial statements, for the absence of footnotes and subject to year-end audit adjustments as to the interim financial statements.
Capitalized terms used but not otherwise defined herein shall have the meanings given them in the Loan Agreement. 
 Date:
______________________ 
 [signature page follows] 

 

	4	 Include in fiscal year end Compliance Certificate only. 

			
	 SI-BONE, INC.,

as Borrower
  

	By	 	  

	Name:	 	  

	Title:	 	  

 Please indicate compliance status since the last Compliance Certificate by circling Yes,
No, or N/A under “Complies” column. 
  

													
	 	  	 Reporting Covenant
	  	 Requirement
	  	 	  	 Complies

	1)	  	Audited Annual Financial Statements	  	180 days after year end	  		  	Yes	  	No	  	N/A
							
	2)	  	Unaudited Annual Financial Statements	  	60 days after year end	  		  	Yes	  	No	  	N/A
							
	3)	  	Quarterly Financial Statements	  	60 days after quarter end	  		  	Yes	  	No	  	N/A
							
	4)	  	SEC Statements	  	5 days after filing, if applicable	  		  	Yes	  	No	  	N/A
							
	5)	  	Other Statements	  	5 days after delivery	  		  	Yes	  	No	  	N/A
							
	6)	  	Legal Action Notice	  	Promptly	  		  	Yes	  	No	  	N/A
							
	7)	  	Consolidated Plan and Financial Forecast	  	No later than March 1	  		  	Yes	  	No	  	N/A
							
	8)	  	Notice of Default, etc.	  	Promptly (within 2 Business Days) after knowledge	  		  	Yes	  	No	  	N/A
							
	9)	  	IP Notice	  	Promptly (within 5 Business Days), when required	  		  	Yes	  	No	  	N/A
							
	10)	  	Governmental Recommendations	  	5 Business Days after receipt	  		  	Yes	  	No	  	N/A
							
	11)	  	Change in Control	  	Promptly (within 2 Business Days), when required	  		  	Yes	  	No	  	N/A
							
	12)	  	Liquidity Shortfall	  	Promptly (within 5 Business Days)	  		  	Yes	  	No	  	N/A
			
		  	Deposit and Securities Accounts	  	(Please list all accounts; attach separate sheet if additional space needed)
					
	 	  	 Bank
	  	 Account Number
	  	 New Account?
	  	 Acct Control

Agmt in place?

	1)	  		  		  	Yes	  	No	  	Yes	  	No
							
	2)	  		  		  	Yes	  	No	  	Yes	  	No
							
	3)	  		  		  	Yes	  	No	  	Yes	  	No

													
							
	4)	  		  		  	Yes	  	No	  	Yes	  	No
							
	5)	  		  		  	Yes	  	No	  	Yes	  	No
							
	6)	  		  		  	Yes	  	No	  	Yes	  	No
							
		  	Financial Covenants	  		  		  		  		  	
							
	1)	  	Minimum Liquidity	  	See Section 5.12	  		  	Yes	  	No	  	N/A
							
	2)	  	Minimum Net Sales	  	See Section 6.17	  		  	Yes	  	No	  	N/A
							
	3)	  	Minimum EBITDA	  	See Section 6.17	  		  	Yes	  	No	  	N/A
							
		  	 Other Matters
	  		  		  		  		  	
						
		  	Have there been any changes in management since the last Compliance Certificate?	  		  	Yes	  	No	  	
						
		  	Have there been any prohibited Transfers?	  		  	Yes	  	No	  	
							
		  	Exceptions	  		  		  		  		  	

  

			
	Please explain any exceptions with respect to the certification above: (If no exceptions exist, state “No exceptions.” Attach separate sheet if additional space needed.)	  	     

    

    

    

  

					
	 LENDER USE ONLY
  
	 		 	
	Compliance Status	 	Yes	 	    No

 EXHIBIT C-1 

 
  

TRANCHE A NOTE 
  

			
	$40,000,000.00	  	Dated: October [__], 2017

 FOR VALUE RECEIVED, the undersigned, SI-BONE, INC., a Delaware
corporation (“Borrower”), HEREBY PROMISES TO PAY to the order of BIOPHARMA CREDIT INVESTMENTS IV SUB LP, a Cayman Islands limited partnership (“Lender”) the principal amount of FORTY MILLION DOLLARS
($40,000,000.00), plus interest on the aggregate unpaid principal amount hereof at a fixed per annum rate (which rate shall be fixed for the duration of this Tranche A Note) equal to eleven and one-half
percent (11.50%) per annum, and in accordance with the terms of the Loan Agreement dated as of October 13, 2017 by and between Borrower and Lender (as amended, restated, supplemented or otherwise modified from time to time, the “Loan
Agreement”). If not sooner paid, the entire principal amount, all accrued and unpaid interest hereunder, all due and unpaid Lender Expenses and any other amounts payable under the Loan Documents shall be due and payable on the Term Loan
Maturity Date. Any capitalized term not otherwise defined herein shall have the meaning attributed to such term in the Loan Agreement. 
 Borrower shall
make equal quarterly payments of principal commencing on the Payment Date that is the 36th-month anniversary of the Tranche A Closing Date, and continuing on the Payment Date of each successive
quarter thereafter. Interest shall accrue on this Tranche A Note commencing on, and including, the date of this Tranche A Note, and shall accrue on this Tranche A Note, or any portion thereof, for the day on which this Tranche A Note or such portion
is paid. Interest on this Tranche A Note shall be payable in accordance with Section 2.3 of the Loan Agreement. 
 Principal, interest and all other
amounts due with respect to this Tranche A Note are payable in lawful money of the United States of America to Lender as set forth in the Loan Agreement and this Tranche A Note. 

The Loan Agreement, among other things, (a) provides for the making of secured Term Loans by Lender to Borrower, and (b) contains provisions for
acceleration of the maturity hereof upon the happening of certain stated events. 
 This Tranche A Note may not be prepaid except as set forth in
Section 2.2(c), Section 6.10(o) or Section 6.17(c) of the Loan Agreement. 
 This Tranche A Note and the obligation of Borrower to repay the
unpaid principal amount of this Tranche A Note, interest thereon, and all other amounts due Lender under the Loan Agreement are secured pursuant to the Collateral Documents. 

Presentment for payment, demand, notice of protest and all other demands and notices of any kind in connection with the execution, delivery, performance and
enforcement of this Tranche A Note are hereby waived. 
 Borrower shall pay all reasonable fees and expenses, including, without limitation, reasonable
attorneys’ fees and costs, incurred by Lender in the enforcement or attempt to enforce any of Borrower’s obligations hereunder not performed when due. 

THIS TRANCHE A NOTE SHALL BE GOVERNED BY, AND CONSTRUED AND INTERPRETED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK, WITHOUT REGARD TO ANY
PRINCIPLES OF CONFLICTS OF LAW THAT COULD REQUIRE THE APPLICATION OF THE LAW OF ANY OTHER JURISDICTION. 
 Note Register; Ownership of Note. The ownership
of an interest in this Tranche A Note shall be registered on a record of ownership maintained by Lender. Notwithstanding anything else in this Tranche A Note to the contrary, the right to the principal of, and stated interest on, this Tranche
A Note may be transferred only if the transfer is 

 registered on such record of ownership and the transferee is identified as the owner of an interest in the
obligation. Lender shall be entitled to treat the registered holder of this Tranche A Note (as recorded on such record of ownership) as the owner in fact thereof for all purposes and shall not be bound to recognize any equitable or other claim to or
interest in this Tranche A Note on the part of any other Person. 

 IN WITNESS WHEREOF, Borrower has caused this Tranche A Note to be duly executed by one of
its officers thereunto duly authorized on the date hereof. 
  

			
	 BORROWER:
  

SI-BONE, INC.,

as Borrower
  

	By	 	  

	Name:	 	  

	Title:	 	  

 EXHIBIT C-2 

TRANCHE B NOTE 
  

			
	$                    .00	  	Dated:                     , 201    

 FOR VALUE RECEIVED, the undersigned, SI-BONE, INC., a Delaware corporation
(“Borrower”), HEREBY PROMISES TO PAY to the order of BIOPHARMA CREDIT INVESTMENTS IV SUB LP, a Cayman Islands limited partnership (“Lender”) the principal amount of
                                 MILLION DOLLARS ($__,000,000.00),5 plus interest on the aggregate unpaid principal amount hereof at a fixed per annum rate (which rate shall be fixed for the duration of this Tranche B Note) equal to eleven and one-half percent (11.50%) per annum, and in accordance with the terms of the Loan Agreement dated as of October 13, 2017 by and between Borrower and Lender (as amended, restated, supplemented or otherwise
modified from time to time, the “Loan Agreement”). If not sooner paid, the entire principal amount, all accrued and unpaid interest hereunder, all due and unpaid Lender Expenses and any other amounts payable under the Loan
Documents shall be due and payable on the Term Loan Maturity Date. Any capitalized term not otherwise defined herein shall have the meaning attributed to such term in the Loan Agreement. 

Borrower shall make equal quarterly payments of principal commencing on the Payment Date that is the
36th-month anniversary of the Tranche A Closing Date, and continuing on the Payment Date of each successive quarter thereafter. Interest shall accrue on this Tranche B Note commencing on, and
including, the date of this Tranche B Note, and shall accrue on this Tranche B Note, or any portion thereof, for the day on which this Tranche B Note or such portion is paid. Interest on this Tranche B Note shall be payable in accordance with
Section 2.3 of the Loan Agreement. 
 Principal, interest and all other amounts due with respect to this Tranche B Note are
payable in lawful money of the United States of America to Lender as set forth in the Loan Agreement and this Tranche B Note. 
 The Loan Agreement, among
other things, (a) provides for the making of secured Term Loans by Lender to Borrower, and (b) contains provisions for acceleration of the maturity hereof upon the happening of certain stated events. 

This Tranche B Note may not be prepaid except as set forth in Section 2.2(c), Section 6.10(o) or
Section 6.17(c) of the Loan Agreement. 
 This Tranche B Note and the obligation of Borrower to repay the unpaid principal amount
of this Tranche B Note, interest thereon, and all other amounts due Lender under the Loan Agreement are secured pursuant to the Collateral Documents. 

Presentment for payment, demand, notice of protest and all other demands and notices of any kind in connection with the execution, delivery, performance and
enforcement of this Tranche B Note are hereby waived. 
 Borrower shall pay all reasonable fees and expenses, including, without limitation, reasonable
attorneys’ fees and costs, incurred by Lender in the enforcement or attempt to enforce any of Borrower’s obligations hereunder not performed when due. 

THIS TRANCHE B NOTE SHALL BE GOVERNED BY, AND CONSTRUED AND INTERPRETED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK, WITHOUT REGARD TO ANY
PRINCIPLES OF CONFLICTS OF LAW THAT COULD REQUIRE THE APPLICATION OF THE LAW OF ANY OTHER JURISDICTION. 
  

	5	 Insert Tranche B Loan Amount 

 Note Register; Ownership of Note. The ownership of an interest in this Tranche B Note shall be
registered on a record of ownership maintained by Lender. Notwithstanding anything else in this Tranche A Note to the contrary, the right to the principal of, and stated interest on, this Tranche B Note may be transferred only if the transfer is
registered on such record of ownership and the transferee is identified as the owner of an interest in the obligation. Lender shall be entitled to treat the registered holder of this Tranche B Note (as recorded on such record of ownership) as the
owner in fact thereof for all purposes and shall not be bound to recognize any equitable or other claim to or interest in this Tranche B Note on the part of any other Person. 

 IN WITNESS WHEREOF, Borrower has caused this Tranche B Note to be duly executed by one of
its officers thereunto duly authorized on the date hereof. 
  

			
	 BORROWER:
  

SI-BONE, INC.,

as Borrower
  

	By	 	  

	Name:	 	  

	Title:	 	  

 EXECUTION VERSION 

AMENDMENT NO. 1 TO LOAN AGREEMENT 

THIS AMENDMENT NO. 1 TO LOAN AGREEMENT, dated as of June 15, 2018 (this “Amendment”), is made between SI-BONE, INC., a Delaware corporation (“Borrower”), and BIOPHARMA CREDIT INVESTMENTS IV SUB LP, a Cayman Islands limited partnership (“Lender”), with respect to the
Loan Agreement referred to below.  
 RECITALS 

WHEREAS, Borrower and Lender are parties to the Loan Agreement, dated as of October 13, 2017 (the “Loan
Agreement”); and 
 WHEREAS, Borrower has requested that Lender, and Lender has agreed to, amend
Section 5.2(a)(i) of the Loan Agreement to extend the due date for annual financial statements for the fiscal year ending December 31, 2017 and amend the definition of “Tranche B Term Amount” in
Section 13.1 of the Loan Agreement. 
 NOW, THEREFORE, in consideration of the mutual agreements, provisions and
covenants contained herein, the parties agree as follows: 
 SECTION 1. DEFINITIONS; INTERPRETATION. 

(a) Terms Defined in Loan Agreement. All capitalized terms used in this Amendment (including in the recitals hereof) and not otherwise
defined herein shall have the meanings assigned to them in the Loan Agreement. 
 (b) Interpretation. The rules of interpretation set
forth in the first paragraph of Section 13.1 of the Loan Agreement shall be applicable to this Amendment and are incorporated herein by this reference. 

SECTION 2. AMENDMENT. Subject to Section 3 of this Amendment: 

(a) Section 5.2(a)(i) of the Loan Agreement is hereby amended and restated in its entirety as follows: 

Annual Financial Statements. So long as Borrower is not a Public Reporting Company, (1) as soon as available, but
in any event (x) for the fiscal year ending December 31, 2017, on or before December 31, 2018 and (y) beginning with the fiscal year ending December 31, 2018, within one hundred eighty (180) days after the end of each
fiscal year of Borrower, a consolidated balance sheet of Borrower and its Subsidiaries as of the end of such fiscal year, and the related consolidated statements of income, cash flows and stockholders’ equity for such fiscal year, setting forth
in each case in comparative form the figures for the previous fiscal year, with such consolidated financial statements to be audited and accompanied by (A) a report and opinion of Borrower’s independent certified public accounting firm of
recognized national or regional standing (which report and opinion shall be prepared in accordance with Applicable Accounting Standards and shall not be subject to any qualification as to scope of audit, but which may be subject to a qualification
as to “going concern”), stating that such financial statements fairly present, in all material respects, the consolidated financial condition, results of operations and cash flows of Borrower as of the dates and for the periods specified
in accordance with Applicable Accounting Standards, and (B) (if and only if Borrower is required to comply with the internal control provisions pursuant to Section 404 of the Sarbanes-Oxley Act of 2002 requiring an attestation report of such
independent certified public accounting firm) an attestation report of such independent certified public accounting firm as to Borrower’s internal controls pursuant to Section 404 of the Sarbanes-Oxley Act of 2002 attesting that such
internal controls meet the requirements of the Sarbanes-Oxley Act of 2002 and (2) as soon as available, but in any event within sixty (60) days after the end of each fiscal year of Borrower, beginning with the fiscal year ending
December 31, 2017, an unaudited consolidated balance sheet of Borrower and its Subsidiaries as of the end of such fiscal year, and the related unaudited consolidated statements of 

 
income, cash flows and stockholders’ equity for such fiscal year, setting forth in each case in comparative form the figures for the previous fiscal year. Each of the foregoing consolidated
financial statements shall be certified by a Responsible Officer as, to his or her knowledge, fairly presenting, in all material respects, the consolidated financial condition, results of operations and cash flows of Borrower and its Subsidiaries as
of the dates and for the periods specified in accordance with Applicable Accounting Standards consistently applied; 
 (b) The definition of
“Tranche B Term Amount” in Section 13.1 of the Loan Agreement is hereby amended and restated in its entirety as follows: 

“Tranche B Loan Amount” means, if Net Sales for the two fiscal quarters preceding the Tranche B Closing Date
taken together are greater than or equal to $28,500,000, $10,000,000. For the avoidance of doubt, if Net Sales for the two fiscal quarters preceding the Tranche B Closing Date taken together are less than $28,500,000, the Tranche B Loan Amount
equals zero. 
 SECTION 3. CONDITIONS OF EFFECTIVENESS. The effectiveness of Section 2 of this
Amendment shall be subject to the following conditions precedent: 
 (a) Borrower and Lender shall have duly executed and delivered this
Amendment pursuant to Section 11.5 of the Loan Agreement; and 
 (b) Borrower shall have paid or reimbursed Lender
for its reasonable out-of-pocket costs and expenses incurred in connection with this Amendment pursuant to Section 2.4 and
Section 11.2(c)(i) of the Loan Agreement. 
 SECTION 4. REPRESENTATIONS AND WARRANTIES; REAFFIRMATION. 

(a) Borrower hereby represents and warrants to each Lender as follows:  

(i) Borrower has all requisite power and authority to enter into this Amendment and to carry out the transactions contemplated hereby. 

(ii) This Amendment has been duly executed and delivered by Borrower and is the legally valid and binding obligation of Borrower, enforceable
against Borrower in accordance with its respective terms, except as may be limited by bankruptcy, insolvency, reorganization, moratorium or similar laws relating to or limiting creditors’ rights generally or by equitable principles relating to
enforceability. 
 (iii) The execution, delivery and performance by Borrower of this Amendment have been duly authorized and do not
(a) conflict with any of Borrower’s Operating Documents, (b) contravene, conflict with, constitute a default under or violate any material Requirements of Law, (c) contravene, conflict or violate any applicable order, writ,
judgment, injunction, decree, determination or award of any Governmental Authority by which Borrower or any of its Subsidiaries or any of its or their respective properties or assets may be bound, (d) require any action by, filing,
registration, or qualification with, or Governmental Approval from, any Governmental Authority (except such Governmental Approvals which have already been obtained and are in full force and effect), (e) constitute a material breach of or a material
default or an event of default under, or result in or permit the termination or acceleration of, any Material Contract by which Borrower is bound or (f) require any approval of stockholders, members or partners or any approval or consent of any
Person except for such approvals or consents which will be obtained on or before the date hereof. 
 (b) Borrower hereby ratifies, confirms,
reaffirms, and acknowledges its obligations under the Loan Documents to which it is a party and agrees that the Loan Documents remain in full force and effect, undiminished by this Amendment, except as expressly provided herein. By executing this
Amendment, Borrower acknowledges that it has read, consulted with its attorneys regarding, and understands, this Amendment.  

  
 2 

 SECTION 5. CHOICE OF LAW, VENUE AND JURY TRIAL WAIVER. 

THIS AMENDMENT SHALL BE GOVERNED BY, AND CONSTRUED AND INTERPRETED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK, WITHOUT REGARD TO ANY
PRINCIPLES OF CONFLICTS OF LAW THAT COULD REQUIRE THE APPLICATION OF THE LAW OF ANY OTHER JURISDICTION. Borrower and Lender submit to the exclusive jurisdiction of the courts of the State of New York sitting in New York County, and of the United
States District Court of the Southern District of New York, and any appellate court from any thereof, and agrees that all claims in respect of any such action, litigation or proceeding may be heard and determined in such New York State court or, to
the fullest extent permitted by Requirements of Law, in such Federal court; provided, however, that nothing in this Amendment shall be deemed to operate to preclude Lender from bringing suit or taking other legal action in any other
jurisdiction to realize on the Collateral or any other security for the Obligations, or to enforce a judgment or other court order in favor of Lender. Borrower expressly submits and consents in advance to such jurisdiction in any action or suit
commenced in any such court, and Borrower hereby waives any objection that it may have based upon lack of personal jurisdiction, improper venue, or forum non conveniens and hereby consents to the granting of such legal or equitable relief as is
deemed appropriate by such court. Borrower hereby waives personal service of the summons, complaints, and other process issued in such action or suit and agrees that service of such summons, complaints, and other process may be made by registered or
certified mail addressed to Borrower at the address set forth in (or otherwise provided in accordance with the terms of) Section 9 of the Loan Agreement and that service so made shall be deemed completed upon the earlier to
occur of Borrower’s actual receipt thereof or three (3) Business Days after deposit in the U.S. mails, proper postage prepaid. 

TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, EACH OF BORROWER AND LENDER WAIVES ITS RIGHT TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF
ACTION ARISING OUT OF OR BASED UPON THIS AMENDMENT OR ANY TRANSACTION CONTEMPLATED HEREBY, INCLUDING CONTRACT, TORT, BREACH OF DUTY AND ALL OTHER CLAIMS. EACH OF BORROWER AND LENDER (A) CERTIFIES THAT NO OTHER PARTY HERETO (AND NO AFFILIATE OF
ANY OTHER PARTY AND NO DIRECTOR, OFFICER, EMPLOYEE, AGENT, TRUSTEE, REPRESENTATIVE, ATTORNEY, ACCOUNTANT, ADVISOR OR CONSULTANT OF ANY OTHER PARTY OR AFFILIATE) HAS REPRESENTED, EXPRESSLY OR OTHERWISE, THAT SUCH OTHER PARTY WOULD NOT, IN THE EVENT
OF LITIGATION, SEEK TO ENFORCE THE FOREGOING WAIVER, (B) ACKNOWLEDGES THAT THE FOREGOING MUTUAL WAIVERS AND CERTIFICATIONS ARE A MATERIAL INDUCEMENT FOR IT AND THE OTHER PARTIES HERETO TO ENTER INTO THIS AMENDMENT AND (C) HAS REVIEWED THIS
WAIVER WITH ITS COUNSEL. 
 SECTION 6. MISCELLANEOUS. 

(a) No Waiver. Except as expressly stated herein, nothing contained herein shall be deemed to constitute a waiver of compliance with any
term or condition contained in the Loan Agreement or any of the other Loan Documents or constitute a course of conduct or dealing among the parties. Except as expressly stated herein, Lender reserves all rights, privileges and remedies under the
Loan Documents. Except as amended hereby, the Loan Agreement and other Loan Documents remain unmodified and in full force and effect. All references in the Loan Documents to the Loan Agreement shall be deemed to be references to the Loan Agreement
as amended hereby. 
 (b) Severability of Provisions. In case any provision in or obligation hereunder shall be invalid, illegal or
unenforceable in any jurisdiction, the validity, legality and enforceability of the remaining provisions or obligations, or of such provision or obligation in any other jurisdiction, shall not in any way be affected or impaired thereby. 

(c) Captions. Section headings herein are included herein for convenience of reference only and shall not constitute a part hereof for
any other purpose or be given any substantive effect. 
 (d) Integration. This Amendment constitutes a Loan Document and, together
with the other Loan Documents, incorporates all negotiations of the parties hereto with respect to the subject matter hereof and is the final expression and agreement of the parties hereto with respect to the subject matter hereof. 

  
 3 

 (e) Counterparts. This Amendment may be executed in any number of counterparts and by
different parties on separate counterparts, each of which, when executed and delivered, is an original, and all taken together, constitute one Amendment. Executed counterparts delivered by facsimile or other electronic transmission (e.g.,
“PDF” or “TIF”) shall be effective as delivery of a manually executed counterpart. 
 (f) Controlling Provisions.
In the event of any inconsistencies between the provisions of this Amendment and the provisions of any other Loan Document, the provisions of this Amendment shall govern and prevail. Except as expressly modified by this Amendment, the Loan Documents
shall not be modified and shall remain in full force and effect. 
 [Remainder of page intentionally left blank] 

  
 4 

 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed as of the
date first written above. 
  

			
	 SI-BONE, INC.,
 as
Borrower

		
	By:	 	/s/ Laura Francis
	Name:	 	Laura Francis
	Title:	 	Chief Financial Officer

  
 Signature Page to
Amendment No. 1 

 BIOPHARMA CREDIT INVESTMENTS IV SUB LP, 

as Lender 

			
		
		 	By: Pharmakon Advisors, LP,
		 	its Investment Manager
		
		 	 By: Pharmakon Management I, LLC,
 its General
Partner

		
	By	 	/s/ Pedro Gonzalez de Cosio
	Name:	 	Pedro Gonzalez de Cosio
	Title:	 	Managing Member

  
 Signature Page to
Amendment No. 1EX-10.21

 Exhibit 10.21 

OFFICE LEASE AGREEMENT 

CALIFORNIA 
 UNIVERSITY
STATION 
 THIS OFFICE LEASE AGREEMENT (the “Lease”) is made and entered into as of the 2/2/2018 day of January,
2018, by and between BIXBY SPE FINANCE 11, LLC, a Delaware limited liability company (“Landlord”), and SI-BONE, INC., a Delaware corporation (“Tenant”). Pursuant
to the terms of this Lease, Landlord agrees to lease the Premises (hereinafter defined) to Tenant and Tenant agrees to lease the Premises from Landlord. The Lease includes the following exhibits and attachments: Exhibit A (Outline and
Location of Premises), Exhibit A-1 (Development Site Plan), Exhibit B (Operating Expenses and Taxes), Exhibit C (Work Letter), Exhibit D (Building Rules and Regulations), Exhibit
E (Statement of Tenant Regarding Lease Commencement), Exhibit F (Recorded Restrictions), Rider No. 1 (Extension Option Rider), Rider No. 2 (Fair Market Rental Rate), and Rider No. 3 (Options in
General). 
  

	1.	 Basic Lease Information. 

 

	 	1.01	 “Building” shall mean the building located at 471 El Camino Real, Santa Clara, California.
“Rentable Square Footage of the Building” is deemed to be 55,480 square feet. The “Development” consists of the parcel(s) of real property commonly known as University Station and located in the City
of Santa Clara, County of Santa Clara, State of California, as shown on the site plan attached hereto as Exhibit A-1 as such area may be expanded or reduced from time to time. Currently, the aggregate
rentable square feet of the buildings located within the Development is approximately 213,093 square feet. “Common Areas” shall mean the portion of the Building and Development that are designated by Landlord for the common
use of tenants and others. 

  

	 	1.02	 “Premises” shall mean the area shown on Exhibit A to this Lease. The Premises are
located on the first (1st) floor of the Building and known as Suite 100. The “Rentable Square Footage of the Premises” is deemed to be 21,848 square feet. 

 

	 	1.03	 “Base Rent”: 

 

					
	 Period or Months of Term
	  	Monthly Base Rent	 
	 1 – 9 *
	  	$	47,500.00	 
	 10 – 12
	  	$	54,620.00	 
	 13 – 24
	  	$	56,258.60	 
	 25 – 36
	  	$	57,946.36	 
	 37 – 48
	  	$	59,684.75	 
	 49 – 60
	  	$	61,475.29	 
	 61 – 72
	  	$	63,319.55	 
	 73 – 84
	  	$	65,219.14	 
	 85 – 86
	  	$	67,175.71	 

  

	*	 Subject to Abatement Period, as defined in Section 3.02 below. 

 

	 	1.04	 “Tenant’s Share”: The sum of Tenant’s Common Area Share (as defined
below) of Common Area Operating Expenses (as defined in Exhibit B attached hereto) and Taxes (as defined in Exhibit B attached hereto), and Tenant’s Building Share (as defined below) of Building
Operating Expenses (as defined in Exhibit B attached hereto) and Taxes. 

 “Tenant’s Common
Area Share”: 10.25%; Tenant’s percentage of Common Area Operating Expenses and Taxes is calculated by dividing the rentable square footage of the Premises by the rentable square footage of all buildings located in the
Development. 
 “Tenant’s Building Share”: 39.38%; Tenant’s percentage of Building Operating
Expenses and Taxes is calculated by dividing the rentable square footage of the Premises by the rentable square footage of the Building. 

  
 -1- 

	 	1.05	 “Term”: A period of eighty-six (86) months.
Subject to Section 2, the Term shall commence on April 1, 2018 (the “Commencement Date”), and shall expire on May 31, 2025 (the “Expiration Date”), subject to earlier
termination, if applicable, in accordance with the terms of this Lease. 

  

	 	1.06	 “Security Deposit”: $199,570.56. 

 

	 	1.07	 “Broker”: Newmark Cornish & Carey (Todd Shaffer) representing Tenant; CBRE, Inc. (Ben
Knight, Rob Shannon and Christian Marent) representing Landlord. 

  

	 	1.08	 “Permitted Use”: To the extent permitted pursuant to terms applicable Laws (as defined
in Section 4 of the Lease) and matters of record (including as referenced in Exhibit F attached hereto), general office, research and development, employee training, surgeon education and training, engineering, warehousing and
administrative support and sales and such other activities as are consistent with a mature medical device company with commercially marketed products and an active R&D pipeline. Tenant shall be responsible for securing from the City of Santa
Clara, California, any conditional use permit which may be required with respect to Tenant’s Permitted Use. 

  

	 	1.09	 “Notice Addresses”: 

 

			
	Landlord:	  	Tenant:
	c/o Bixby Land Company	  	Prior to Commencement:
	1501 Quail, Suite 230	  	SI-BONE, Inc.
	Newport Beach, California 92660	  	3055 Olin Ave., Ste 2200
	Attention: Property Manager, University	  	San Jose, California 95128
	Station	  	Attention: General Counsel
		
	Lock box address for payment of Rent:	  	
	Bixby SPE Finance 11, LLC	  	After to Commencement:
	P.O. Box 51239	  	SI-BONE, Inc.
	Los Angeles, California 90051-5539	  	471 El Camino Real, Suite 100
		  	Santa Clara, California 95050
		  	Attention: Director of Operations

  

	 	1.10	 “Landlord Work” means the work, if any, that Landlord is obligated to perform in the
Premises pursuant to a separate work letter agreement (the “Work Letter”) attached to this Lease as Exhibit C. 

  

	 	1.11	 “Parking”: Subject to Section 29 below, Tenant shall have non-exclusive access to seventy-eight (78) surface parking spaces in common with other tenants and occupants of the Development. All parking rights granted to Tenant hereunder may be utilized by Tenant’s
agents, licensees, assignees, subtenants, customers, employees, contractors, suppliers and invitees (“Tenant’s Parties” or “Tenant Parties”) on the same basis as they are available
to Tenant (subject to the terms of Exhibit D attached hereto). 

  

	 	1.12	 “Guarantor”: None. 

 

	2.	 Commencement Date; Possession. 

2.01 If Landlord is required to perform Landlord Work (defined in the Work Letter) prior to the Commencement Date: (a) the date set forth
in Section 1.05 above as the Commencement Date shall instead be defined as the “Target Commencement Date”; (b) the actual Commencement Date shall be the date on which the Landlord Work is Substantially
Complete (as defined in the Work Letter); and (c) the Expiration Date will be the last day of the Term as determined based upon the actual Commencement Date. Landlord’s failure to Substantially Complete the Landlord Work by the Target
Commencement Date shall not be a default by Landlord or otherwise render Landlord liable for damages. If Landlord is delayed in the performance of the Landlord Work as a result of a Tenant Delay (as defined in the Work Letter), the Landlord Work
shall be deemed to be Substantially Complete on the date that Landlord could reasonably have been expected to Substantially Complete the Landlord Work absent any Tenant Delay. It is further understood and agreed that if for any reason the
Commencement Date occurs 

  
 -2- 

 pursuant to the terms of this Lease on a day other than the first (1st) day of a calendar month, the period commencing on the Commencement Date and ending on the last day of the calendar month in which the Commencement Date occurs shall be an initial stub period which
shall be added to the initial Term and Tenant shall pay all Rent (defined in Section 3 below) and other charges with respect to such stub period (on a prorated basis as referenced in Section 3 below) at the same rate
applicable to the first (1st) full calendar month of this Lease. Following such stub period and commencing as of the first (1st) day of the first
(1st) full calendar month following the month in which the Commencement Date occurs, Tenant shall commence the payment of Rent and other charges payable hereunder as if the initial Term had
actually commenced on such date. The use of the stub period described above is intended to provide for ease of administration and calculation of all amounts owed hereunder, it being agreed that all rental adjustments will be determined as of the
first (1st) day of a calendar month and the Term of the Lease will end as of the last day of a calendar month (unless earlier terminated pursuant to the terms hereof). 

2.02 Subject to Landlord performing the required Landlord Work, the Premises are accepted by Tenant in
“AS-IS” condition and configuration without any representations or warranties by Landlord. Landlord shall not be liable for any failure to deliver possession of the Premises or any other space due to
the holdover or unlawful possession of such space by any party. In such event, the Commencement Date for such space shall be postponed until the date Landlord delivers possession of the Premises to Tenant free from occupancy by any party. 

2.03 Within thirty (30) days after the Commencement Date, Tenant shall return an executed Statement of Tenant Regarding Lease Commencement
in the form attached hereto as Exhibit E. The Statement of Tenant Regarding Lease Commencement shall be binding upon Tenant unless Tenant objects thereto in writing within such 30-day period. 

2.04 So long as (i) this Lease has been fully executed and delivered by the parties hereto, (ii) Landlord has received the first
(1st) monthly installment of Base Rent pursuant to Section 3 below and the Security Deposit (to be maintained pursuant to the terms of Section 5 below), (iii) Landlord Work is Substantially Complete, and (iv) Landlord
has received insurance certificates evidencing that Tenant is carrying the insurance required to be carried by Tenant pursuant to the terms of Section 15 below, Tenant shall have the right to access the Premises on the date that is two
(2) weeks prior to the actual Commencement Date, for the purpose of the installation of Tenant’s furniture, fixtures and equipment therein (the “Early Access Period”). During such Early Access Period, all of the terms and
conditions of this Lease shall apply, including, without limitation, Tenant’s obligation to pay to Landlord all sums and charges required to be paid by Tenant under this Lease including, without limitation, charges in excess of the Building
standard level of services supplied by Landlord pursuant to the terms of Section 8 below, but excluding Base Rent, Tenant’s Common Area Share and Tenant’s Building Share. Further, any work to be performed by Tenant or its
contractors within the Premises during such Early Access Period shall be performed in strict accordance with the terms of Section 10 of this Lease, including obtaining Landlord’s prior approval of plans for any cabling, wiring or
other work which may affect systems or structure or be visible from outside the Premises and causing all contractors to comply with the Development’s construction rules and regulations. Tenant shall have the use of the parking passes during the
Early Access Period. During such Early Access Period, Tenant shall not be obligated to pay Base Rent, Tenant’s Common Area Share or Tenant’s Building Share (as such terms are defined in Exhibit B attached hereto) for the Premises so
accessed by Tenant until the occurrence of the Commencement Date (and no such Base Rent, Tenant’s Common Area Share or Tenant’s Building Share shall accrue during such Early Access Period). 

 

	3.	 Rent. 

3.01 Upon execution of this Lease, Tenant shall pay to Landlord the sum of $47,500.00 constituting Rent due and payable by Tenant for the first
full calendar month of the Term for which Rent is payable hereunder. Tenant shall pay Landlord, without any setoff or deduction, all Base Rent and Additional Rent for the Term (collectively referred to as “Rent”) when due.
“Additional Rent” means all sums (exclusive of Base Rent) that Tenant is required to pay Landlord under this Lease, including, without limitation, payments for insurance, repairs and parking lot maintenance/repair and
Tenant’s Common Area Share and Tenant’s Building Share of Taxes and Operating Expenses. Tenant shall pay and be liable for all rental, sales and use taxes (but excluding income taxes), if any, imposed upon or measured by Rent. Base Rent
and recurring monthly charges of estimated Additional Rent shall be due and payable in advance on the first day of each calendar month without notice or demand. All other items of Rent shall be due and payable by Tenant on or before thirty
(30) days after billing by Landlord. All Rent payable by Tenant hereunder shall be paid to Landlord in lawful money of the United States of America, by check or wire transfer made payable to the entity constituting Landlord hereunder and sent
to the lock box designated in Section 1.09 of the Basic Lease Information, or to such other location or address as Landlord 

  
 -3- 

 may designate from time to time. Tenant shall pay Landlord an administration fee equal to five percent (5%)
of all Rent past due beyond any applicable grace period. In addition, past due Rent shall accrue interest at twelve percent (12%) per annum (or the maximum rate legally permissible, whichever is less). Rent for any partial month during the Term
shall be prorated. No endorsement or statement on a check or letter accompanying payment shall be considered an accord and satisfaction. Tenant’s covenant to pay Rent is independent of every other covenant in this Lease. 

3.02 Notwithstanding anything to the contrary contained herein and provided that no Default by Tenant occurs hereunder, Landlord hereby
agrees that Tenant shall not be required to pay monthly Base Rent for the first (1st) and second (2nd) full months of the initial Term (the
“Abatement Period”). During the Abatement Period, Tenant shall still be responsible for the payment of all of its other monetary obligations under this Lease. In the event of a Default by Tenant under the terms of this Lease
that results in termination of this Lease in accordance with the provisions of Section 19 hereof, then as a part of the recovery set forth in Section 20 of this Lease, Landlord shall be entitled to the recovery of the monthly
Base Rent that was abated under the provisions of this Section 3. 
 3.03 In accordance with the Section 1.03 above, Tenant
shall be obligated to pay Base Rent with respect to only 19,000 rentable square feet of the Premises for the first (1st) nine (9) months of the initial Term (the “Phase-In Period”)
at the rate of $47,500.00 per month (calculated at the rate of $2.50 per rentable square foot per month). Upon the expiration of the Phase-In Period, and for the remainder of the Term, Tenant shall be
obligated to pay Base Rent with respect to the entire rentable square footage of the Premises at the rates listed in Section 1.03 above. During the Phase-In Period, Tenant shall remain liable for
the full payment of all of its other monetary obligations under this Lease, and Tenant’s Common Area Share and Tenant’s Building Share shall continue to be calculated as specified in Section 1.04 above, using the entire
rentable square footage of the Premises. 
 4. Compliance with Laws; Use. The Premises shall be used for the Permitted Use and for no other use
whatsoever. Tenant shall comply with all statutes, codes, ordinances, orders, rules and regulations of any municipal or governmental entity (collectively, “Laws”), regarding the operation of Tenant’s business and the use,
condition, configuration and occupancy of the Premises. Tenant shall comply with the Rules and Regulations of the Development attached hereto as Exhibit D and such other reasonable rules and regulations adopted by Landlord from time to time.
In addition, Tenant shall comply with all covenants, conditions and restrictions in effect from time to time with respect to the Development, including, as listed in Exhibit F attached hereto. Furthermore, as part of its obligations
hereunder, from and after the Commencement Date, Tenant shall, at its sole cost and expense, observe and comply with the provisions of Title III of the Americans with Disabilities Act of 1990, as amended and any regulations promulgated pursuant
thereto (collectively, the “ADA”), as it pertains to Tenant’s use, occupancy, improvement and alteration of the Premises. Tenant shall not use or allow the Premises to be used for any improper, immoral, unlawful or reasonably
objectionable purpose, provided that Landlord understands and acknowledges that Tenant’s activities sometimes include simulated surgical procedures using human tissue and/or portions of human cadavers. Provided Tenant conducts such activities
in a discreet and respectful manner that does not disturb other Building tenants, and in compliance with all applicable laws, rules, regulations, codes and the like, Landlord acknowledges that such activities are not reasonably objectionable. Tenant
shall not do or permit to be done anything which will obstruct or interfere with the rights of other tenants or occupants of the Development, or injure or annoy them. Tenant shall not cause, maintain or permit any nuisance in, on or about the
Premises or the Development, nor commit or suffer to be committed any waste in, on or about the Premises. 
 5. Security Deposit. The Security Deposit
shall be delivered to Landlord upon the execution of this Lease by Tenant and held by Landlord without liability for interest (unless required by Laws) as security for the performance of Tenant’s obligations. The Security Deposit is not an
advance payment of Rent or a measure of damages. Landlord may use all or a portion of the Security Deposit to satisfy past due Rent, to cure any Default (defined in Section 18 below) by Tenant, or to compensate Landlord for any other
loss or damage Landlord may suffer by reason of Tenant’s Default. If Landlord reasonably uses any portion of the Security Deposit, Tenant shall on demand restore the Security Deposit to its original amount, and Tenant’s failure to do so
shall be a Default under this Lease. Landlord shall return any unapplied portion of the Security Deposit to Tenant within forty-five (45) days after the later to occur of: (a) payment of the final Rent due from Tenant; or (b) the
later to occur of the Expiration Date or the date Tenant surrenders the Premises to Landlord in compliance with Section 24 below. Landlord shall not be required to keep the Security Deposit separate from its other accounts. Tenant hereby
waives the provisions of Section 1950.7 of the California Civil Code, or any successor Laws now or hereafter in effect. 

  
 -4- 

 6. Tenant’s Use of Common Areas. During the Term of this Lease, Tenant shall have the
nonexclusive right to use in common with Landlord and all persons, firms and corporations conducting business in the Development and their respective customers, guests, licensees, invitees, subtenants, employees and agents (collectively,
“Development Occupants”), subject to the terms of this Lease, the Rules and Regulations attached hereto as Exhibit D and all covenants, conditions and restrictions now or hereafter affecting the Development, including
the covenants, conditions and restrictions set forth in Exhibit F attached hereto (collectively, the “Common Areas”): the parking facilities of the Development which serve the Building, loading and unloading
areas, trash areas, roadways, sidewalks, walkways, parkways, driveways, landscaped areas, and similar areas and facilities situated within the Development and appurtenant to the Building which are not reserved for the exclusive use of any
Development Occupants. Subject to Tenant’s obligation to pay Tenant’s Common Area Share of the cost thereof through Common Area Operating Expenses and Taxes, Landlord shall maintain the Common Areas (including, without limitation, the
truck loading and parking areas and trash removal) in a clean, orderly, lighted and reasonably attractive condition comparable with similar projects in the vicinity with, subject to the remainder of this Lease, continuous ingress and egress to and
from public roadways to the Premises and the parking areas appurtenant to the Premises. 
 7. Landlord’s Reservation of Rights. Provided
Tenant’s use of and access to the Premises and parking to be provided to Tenant under this Lease is not interfered with in an unreasonable manner, Landlord reserves for itself and for all other owner(s) and operator(s) of the Common Areas and
the balance of the Development, the right from time to time, with at least one business day of notice (except in emergencies) to: (i) install, use, maintain, repair, replace and relocate pipes, ducts, conduits, wires and appurtenant meters and
equipment above the ceiling surfaces, below the floor surfaces, within the walls and in the central core areas of the Building; (ii) make changes to the design and layout of the Development, including, without limitation, changes to buildings,
driveways, entrances, loading and unloading areas, direction of traffic, landscaped areas and walkways, and, subject to the parking provisions contained in Section 29 below and Exhibit D attached hereto, parking spaces and parking
areas; and (iii) use or close temporarily the Common Areas and/or other portions of the Development while engaged in making improvements, repairs or alterations to the Building, the Development, or any portion thereof. 

 

	8.	 Operating Expenses and Taxes. 

8.01 Throughout the Term of this Lease, commencing on the Commencement Date, Tenant agrees to pay Landlord as Additional Rent in accordance
with the terms of this Section 8, Tenant’s Common Area Share of the Common Area Operating Expenses and Tenant’s Building Share of the Building Operating Expenses and Taxes and all costs and expenses for the operation,
maintenance, repair, and replacement of the Development including, without limitation, those costs and expenses listed on Exhibit B attached hereto. 

8.02 Prior to the Commencement Date and on or about April 15th of each subsequent calendar year during the Term of this Lease, Landlord will
endeavor to deliver to Tenant a statement (“Estimate Statement”) wherein Landlord will reasonably estimate both the Operating Expenses and Taxes and Tenant’s Share thereof (the “Monthly Operating Expense
Charge”) for the then current calendar year. Tenant agrees to pay Landlord, as Additional Rent, Tenant’s estimated Monthly Operating Expense Charge each month thereafter, beginning with the next installment of rent due, until such time
as Landlord issues a revised Estimate Statement or the Estimate Statement for the succeeding calendar year; except that, concurrently with the regular monthly rent payment next due following the receipt of each such Estimate Statement, Tenant agrees
to pay Landlord an amount equal to one (1) monthly installment of Tenant’s estimated Monthly Operating Expense Charge multiplied by the number of months from January, in the current calendar year, to the month of such rent payment next
due, all months inclusive (less any applicable Operating Expenses and Taxes already paid). If at any time during the Term of this Lease, but not more often than quarterly, Landlord reasonably determines that Tenant’s Share of Operating Expenses
and Taxes for the current calendar year will be greater than the amount set forth in the then current Estimate Statement, Landlord may issue a revised Estimate Statement and Tenant agrees to pay Landlord, with the next month’s rent payment due
following receipt of the revised Estimate Statement, the difference between the amount owed by Tenant under such revised Estimate Statement and the amount owed by Tenant under the original Estimate Statement for the portion of the then current
calendar year which has expired (“Makeup Payment”). Thereafter, Tenant agrees to pay Tenant’s Monthly Operating Expense Charge based on such revised Estimate Statement until Tenant receives the next
calendar year’s Estimate Statement or a new revised Estimate Statement for the current calendar year. 

  
 -5- 

 8.03 By April 15th of each calendar
year during the Term of this Lease, Landlord will also endeavor to deliver to Tenant a statement (“Actual Statement”) which states Tenant’s Share of the actual Operating Expenses and Taxes for the preceding calendar
year. If the Actual Statement reveals that Tenant’s Share of the actual Operating Expenses and Taxes is more than the total Additional Rent paid by Tenant for Operating Expenses and Taxes on account of the preceding calendar year, Tenant agrees
to pay Landlord the difference in a lump sum within thirty (30) days of receipt of the Actual Statement. If the Actual Statement reveals that Tenant’s Share of the actual Operating Expenses and Taxes is less than the Additional Rent paid
by Tenant for Operating Expenses and Taxes on account of the preceding calendar year, Landlord will credit any overpayment toward the next monthly installment(s) of Tenant’s Share of the Operating Expenses and Taxes due under this Lease or, in
the event this Lease terminates before Tenant is able to receive such credit, Landlord will pay the amount of such overpayment to Tenant within thirty (30) days of the date Landlord finalizes the Actual Statement. 

8.04 Any delay or failure by Landlord in delivering any Estimate Statement or Actual Statement pursuant to this Section 8 will not
constitute a waiver of its right to require an increase in rent nor will it relieve Tenant of its obligations pursuant to this Section 8, except that Tenant will not be obligated to make any payments based on such Estimate Statement or
Actual Statement until thirty (30) days after receipt of such Estimate Statement or Actual Statement. If Tenant does not object to any Estimate Statement or Actual Statement within ninety (90) days after Tenant receives any such statement,
such statement will be deemed final and binding on Tenant. Even though the Term has expired and Tenant has vacated the Premises, when the final determination is made of Tenant’s Share of the actual Operating Expenses and Taxes for the year in
which this Lease terminates, Tenant agrees to promptly pay any increase due over the estimated expenses paid and, conversely, any overpayment made in the event said expenses decrease shall promptly be rebated by Landlord to Tenant. Such obligation
will be a continuing one which will survive the expiration or termination of this Lease. Prior to the expiration or sooner termination of the Lease Term and Landlord’s acceptance of Tenant’s surrender of the Premises, Landlord will have
the right to estimate the actual Operating Expenses and Taxes for the then current Lease Year and to collect from Tenant prior to Tenant’s surrender of the Premises, Tenant’s Share of any excess of such actual Operating Expenses and Taxes
over the estimated Operating Expenses and Taxes paid by Tenant in such Lease Year. 
 8.05 Notwithstanding anything to the contrary in this
Lease, Landlord shall have the right, from time to time, to equitably allocate some or all of the Operating Expenses and Taxes among different tenants and/or different buildings of the Development (the “Cost Pools”). Such
Cost Pools may include, without limitation, office space tenants and retail space tenants in the Development and may be modified to take into account the addition of any additional buildings within the Development. Accordingly, in the event of such
allocation into Cost Pools, Tenant’s Share, Tenant’s Common Area Share and Tenant’s Building Share shall be appropriately adjusted to reflect such allocation. 

8.06 Landlord shall provide the following services (“Landlord’s Services”) on all days (unless otherwise
stated below) during the Lease Term. 
 (a) Subject to limitations imposed by all governmental rules, regulations and guidelines applicable
thereto, Landlord shall provide heating and air conditioning (“HVAC”) for normal comfort for normal office use in the Premises during Building Hours (defined below). As used in this Lease, “Building
Hours” are from 8:00 a.m. to 6:00 p.m. Monday through Friday, except for the date of observation of New Year’s Day, Memorial Day, Independence Day, Labor Day, Thanksgiving Day, and Christmas Day (collectively, the
“Holidays”). If Tenant desires to use HVAC during non-Building Hours, Tenant shall give Landlord such prior notice, if any, as Landlord shall from time to time establish as appropriate, of
Tenant’s desired use in order to supply such utilities, and Landlord shall supply such utilities to Tenant at such hourly cost to Tenant (which shall be treated as Additional Rent) as Landlord shall from time to time establish. The current
hourly cost, which is subject to increase in Landlord’s reasonable discretion, is Thirty-Five Dollars ($35.00). Notwithstanding the foregoing, pursuant to and in accordance with the terms of this Section 8.06, Tenant shall be
entitled to the continued use and maintenance of the existing supplemental HVAC equipment within the Premises (collectively, the “Supplemental HVAC Equipment”). Tenant’s installation, use and maintenance of the
Supplemental HVAC Equipment shall be at Tenant’s sole cost and expense and shall be installed in a location approved by Landlord, which approval shall not be unreasonably withheld, and Tenant shall at all times maintain the Supplemental HVAC
Equipment in good condition and repair. The Supplemental HVAC Equipment shall be separately metered at Tenant’s sole cost and expense (including condensor water and electricity, as applicable), and all costs and utility charges relating to the
installation, operation, maintenance and repair of such Supplemental HVAC Equipment shall be paid for by Tenant. If Tenant elects to install any additional supplemental HVAC equipment pursuant to the terms of this Section 8.06, Tenant
shall install and operate the additional supplemental HVAC equipment in compliance with applicable laws and shall at all times maintain the additional supplemental HVAC equipment, in good condition and repair. If Tenant desires to relocate the
Supplemental HVAC Equipment, Tenant shall obtain Landlord’s prior written 

  
 -6- 

 approval of the new location, and any costs incurred due to the relocation shall be Tenant’s sole
responsibility. Upon the expiration or earlier termination of this Lease, Tenant shall surrender the Supplemental HVAC Equipment to Landlord in good condition, normal wear and tear excepted, or, at Landlord’s option, Tenant shall remove the
Supplemental HVAC Equipment and repair any damage to the Premises and/or the Building caused by such removal. 
 (b) Except as otherwise
approved in writing by Landlord: (1) Landlord shall provide adequate electrical wiring and facilities for connection to Tenant’s lighting fixtures and incidental use equipment, provided that (i) the connected electrical load of
the incidental use equipment does not exceed an average of 2.5 watts per rentable square foot of the Premises and the electricity so furnished for incidental use equipment will be at a nominal one hundred twenty (120) volts and no electrical
circuit for the supply of such incidental use equipment will require a current capacity exceeding twenty (20) amperes, and (ii) the connected electrical load of Tenant’s lighting fixtures does not exceed an average of 1.5 watts per
rentable square foot of the Premises and the electricity so furnished for Tenant’s lighting will be at a nominal one hundred twenty (120) volts, which electrical usage shall be subject to applicable laws and regulations, including Title
24. Tenant will design Tenant’s electrical system serving any equipment producing nonlinear electrical loads to accommodate such nonlinear electrical loads, including, but not limited to, oversizing neutral conductors, derating transformers
and/or providing power-line filters; (3) engineering plans shall include a calculation of Tenant’s fully connected electrical design load with and without demand factors and shall indicate the number of watts of unmetered and submetered
loads; and (4) Tenant shall bear the cost of replacement of lamps, starters and ballasts for non-Building standard lighting fixtures within the Premises. 

(c) Landlord shall provide city water from the regular Building outlets for drinking, lavatory and toilet purposes in the Building Common
Areas. 
 (d) (Intentionally Omitted) 

(e) Landlord shall provide nonexclusive, non-attended automatic passenger elevator service during the
Building Hours and shall have one elevator available at all other times. 
 (f) Landlord shall provide nonexclusive freight elevator service
subject to scheduling by Landlord. 
 (g) Except as otherwise provided in this Lease and subject to the Rules and Regulations, Tenant shall
have full access and use of the Premises, the Building and the Common Areas (including, without limitation, the parking lot) twenty-four (24) hours a day, seven (7) days a week, fifty-two
(52) weeks a year, subject to Landlord’s reasonable security requirements, any construction in the Development and/or closures due to emergency. 

Tenant shall cooperate fully with Landlord at all times and abide by all regulations and requirements that Landlord may reasonably prescribe
for the proper functioning and protection of the HVAC, electrical, mechanical and plumbing systems. 
 8.07 Tenant agrees to contract
directly for and pay for any utilities other than Landlord’s Services (“Tenant’s Utilities”). All expenses incurred by Landlord for Landlord’s Services shall be included as part of Building Operating Expenses.
Landlord will not be liable to Tenant for any failure to furnish any of the foregoing utilities and services if such failure is caused by all or any of the following: (i) accident, breakage or repairs; (ii) strikes, lockouts or other labor
disturbance or labor dispute of any character; (iii) governmental regulation, moratorium or other governmental action or inaction; (iv) inability despite the exercise of reasonable diligence to obtain electricity, water or fuel; or
(v) any other cause beyond Landlord’s reasonable control. In addition, in the event of any stoppage or interruption of services or utilities, Tenant shall not be entitled to any abatement or reduction of rent and no eviction of Tenant will
result from such failure and Tenant will not be relieved from the performance of any covenant or agreement in this Lease because of such failure. 

8.08 Tenant shall not, without Landlord’s prior written consent, use heat-generating machines, machines other than normal fractional
horsepower office machines, or equipment or lighting other than Building standard lights in the Premises outside of Tenant’s lab space which is intended to be served by separate HVAC systems, which may affect the temperature otherwise
maintained by the air conditioning system or increase the water normally furnished for the Premises by Landlord pursuant to the terms of Section 8.06 of this Lease. If such 

  
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 consent is given, Landlord shall have the right to install supplementary air conditioning units or other
facilities in the Premises, including supplementary or additional metering devices, and the cost thereof, including the cost of installation, operation and maintenance, increased wear and tear on existing equipment and other similar charges, shall
be paid by Tenant to Landlord upon billing by Landlord. All costs incurred during the term for Tenant’s HVAC, including, without limitation, electricity, maintenance and repair, shall be paid by Tenant to Landlord upon demand as Additional
Rent. If Tenant uses water, electricity, heat or air conditioning in excess of that supplied by Landlord pursuant to Section 8.06 of this Lease, Tenant shall pay to Landlord, upon billing, the cost of such excess consumption, the cost of
the installation, operation, and maintenance of equipment which is installed in order to supply such excess consumption, and the cost of the increased wear and tear on existing equipment caused by such excess consumption; and Landlord may install
devices to separately meter any increased use and in such event Tenant shall pay the increased cost directly to Landlord, on demand, at the rates charged by the public utility company furnishing the same, including the cost of such additional
metering devices. Tenant’s use of electricity shall never exceed the capacity of the feeders to the Development or the risers or wiring installation, and Tenant shall not install or use or permit the installation or use of any computer or
electronic data processing equipment in the Premises, without the prior written consent of Landlord. 
 8.09 Tenant agrees that Landlord
shall not be liable for damages, by abatement of Rent or otherwise, for failure to furnish or delay in furnishing any service (including telephone and telecommunication services), or for any diminution in the quality or quantity thereof, when such
failure or delay or diminution is occasioned, in whole or in part, by breakage, repairs, replacements, or improvements, by any strike, lockout or other labor trouble, by inability to secure electricity, gas, water, or other fuel at the Building or
Development after reasonable effort to do so, by any riot or other dangerous condition, emergency, accident or casualty whatsoever, by act or default of Tenant or other parties, or by any other cause. Furthermore, Landlord shall not be liable under
any circumstances for a loss of, or injury to, property or for injury to, or interference with, Tenant’s business, including, without limitation, loss of profits, however occurring, through or in connection with or incidental to a failure to
furnish any of the services or utilities as set forth herein. Landlord may comply with voluntary controls or guidelines promulgated by any governmental entity relating to the use or conservation of energy, water, gas, light or electricity or the
reduction of automobile or other emissions without creating any liability of Landlord to Tenant under this Lease. In no event shall any failure to furnish, delay in furnishing, unavailability or diminution in quality or quantity of any such utility
or other services or interference with Tenant’s business operations as a result of any such occurrence constitute an actual or constructive eviction of Tenant or a breach of an implied warranty by Landlord, provided Landlord is making
commercially reasonable efforts to restore such failure, delay, unavailability or diminution. 
 8.10 Landlord shall not be obligated to
provide any janitorial services or window washing services to the Premises or replace any light bulbs, lamps, starters and ballasts for lighting fixtures within the Premises. Tenant shall be solely responsible, at Tenant’s sole cost and
expense, for (i) performing all janitorial services (including, without limitation, window washing services), trash removal and other cleaning of the Premises, and (ii) replacement of all light bulbs, lamps, starters and ballasts for
lighting fixtures within the Premises, all as appropriate to maintain the Premises in a first-class manner consistent with the first-class nature of the Building and Development. Such services to be provided by Tenant shall be performed by
contractors and pursuant to service contracts approved by Landlord, which approval shall not be unreasonably withheld. Landlord shall have the right to inspect the Premises upon reasonable notice to Tenant and to require Tenant to provide additional
cleaning, if necessary. In the event Tenant shall fail to provide any of the services described in this Section 8.10 to be performed by Tenant within five (5) days after notice from Landlord, which notice shall not be required in
the event of an emergency, Landlord shall have the right to provide such services and any charge or cost incurred by Landlord in connection therewith shall be deemed Additional Rent due and payable by Tenant upon receipt by Tenant of a written
statement of cost from Landlord. 
 8.11 Tenant acknowledges that Landlord and/or Tenant may from time to time be requested or required to
obtain, report and/or disclose certain energy consumption information with regard to the Premises, which may include, without limitation, benchmarking data for the U.S. Environmental Protection Agency’s ENERGY STAR® Portfolio Manager and information relating to compliance with “green building” initiatives, including, if applicable, the Leadership in Energy & Environmental Design (LEED)
certification program. Tenant shall throughout the Term of this Lease, comply with all Federal, State or local laws, rules and regulations relating to consumption of utilities, energy or energy efficiency (as they may be in enacted or in effect from
time to time, “Energy Regulations”), and Tenant shall, upon request by Landlord or Landlord’s lender, deliver and/or disclose such information regarding the consumption of utilities at the Premises as may be
required to comply with applicable Energy Regulations. Further, Tenant authorizes Landlord to disclose such information and data regarding the Premises as may be requested or required from time to time to comply with Energy Regulations. 

  
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 9. Leasehold Improvements. All improvements in and to the Premises, including any Alterations
(defined below) (collectively, “Leasehold Improvements”) shall remain upon the Premises at the end of the Term without compensation to Tenant. Landlord, however, by written notice to Tenant prior to the Expiration Date, may require
Tenant, at its expense, to remove any electronic, phone and data cabling and related equipment (collectively, “Cable”) installed by or for the benefit of Tenant and/or any Landlord Work or Alterations that, in Landlord’s
reasonable judgment, are not standard office improvements and are of a nature that would require material removal and repair costs (collectively referred to as “Required Removables”), unless Tenant requests and obtains
Landlord’s written agreement, at the time of Landlord’s approval of the Leasehold Improvements to be made by Tenant, that such Leasehold Improvements need not be removed. 

 

	10.	 Repairs and Alterations. 

10.01 Tenant shall periodically inspect the Premises to identify any conditions that are dangerous or in need of maintenance or repair and
shall promptly provide Landlord with notice of any such conditions. Tenant shall, at its sole cost and expense, promptly perform all maintenance and repairs to the Premises that are not Landlord’s express responsibility under this Lease, and
shall keep the Premises in good condition and repair, reasonable wear and tear excepted. Tenant shall perform repairs in conformance with any and all applicable rules and regulations of any federal, state, county or municipal code or ordinance
(including, California Energy Code, Title 24) and pursuant to a valid building permit, issued by the city in which the Building is located, and in conformance with Landlord’s construction rules and regulations. If Tenant fails to make any
repairs to the Premises for more than fifteen (15) days after notice from Landlord (although notice shall not be required in an emergency), Landlord may make the repairs, and Tenant shall pay the reasonable cost of the repairs, together with an
administrative charge in an amount equal to ten percent (10%) of the cost of the repairs. Landlord shall perform all maintenance and repairs upon the: (a) structural elements of the Building; (b) mechanical, electrical, plumbing and
fire/life safety systems serving the Building in general; (c) Common Areas; (d) roof of the Building; (e) exterior windows of the Building; and (f) elevators serving the Building. Tenant hereby waives any and all rights under and
benefits of subsection 1 of Section 1932, and Sections 1941 and 1942 of the California Civil Code, or any similar or successor Laws now or hereinafter in effect. 

10.02 Tenant shall not make alterations, repairs, additions or improvements or install any cable (collectively referred to as
“Alterations”) without first obtaining the written consent of Landlord in each instance, which consent Landlord shall not unreasonably delay, withhold or condition unless the same affects the structural integrity of the Building or
would likely have an adverse effect on other Building tenants. In order to obtain such approvals, Tenant shall furnish Landlord with plans and specifications; names of contractors acceptable to Landlord; required permits and approvals; evidence of
contractor’s and subcontractor’s insurance in amounts reasonably required by Landlord and naming Landlord as an additional insured; and any security for performance in amounts reasonably required by Landlord. Tenant shall construct such
Alterations in conformance with any and all applicable rules and regulations of any federal, state, county or municipal code or ordinance (including, California Energy Code, Title 24) and pursuant to a valid building permit, issued by the city in
which the Building is located, and in conformance with Landlord’s construction rules and regulations. Tenant shall reimburse Landlord for any sums paid by Landlord for third party examination of Tenant’s plans for Alterations. In addition,
Tenant shall pay Landlord a fee for Landlord’s oversight and coordination of any Alterations equal to three percent (3%) of the cost of the Alterations. Upon completion, Tenant shall furnish
“as-built” plans for Alterations, completion affidavits and full and final waivers of lien. Notwithstanding the foregoing, Tenant shall have the right, without Landlord’s consent, but upon three
(3) business days prior written notice to Landlord, to make strictly cosmetic, non-structural additions and alterations to the Premises that do not (i) involve the expenditure of more than $25,000.00
in the aggregate in any twelve (12) month period during the initial Term, (ii) affect the appearance of the Building or any areas outside the Premises, (iii) affect or impact in any way the systems or structure of the Building, or
(iv) require the issuance of a building permit. 
 11. Entry by Landlord. Landlord may enter the Premises to inspect or, within nine months prior
to expiration of this Lease, show the Premises to other potential tenants, to clean and make repairs, alterations or additions and to perform or facilitate maintenance, repairs, alterations or additions to any portion of the Building. Except in
emergencies or to provide Building services, Landlord shall provide Tenant with reasonable prior verbal notice of entry. Entry by Landlord shall not constitute a constructive eviction or entitle Tenant to an abatement or reduction of Rent. 

  
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	12.	 Assignment and Subletting. 

12.01 Tenant shall not assign, sublease, transfer or encumber any interest in this Lease or allow any third party to use any portion of the
Premises (collectively or individually, a “Transfer”) without the prior written consent of Landlord, which such consent shall not be unreasonably delayed, withheld or conditioned if Landlord does not exercise its recapture rights.
Any attempted Transfer in violation of this Section shall, at Landlord’s option, be void. Within fifteen (15) business days after receipt of executed copies of the transfer documentation and such other information as Landlord may request,
Landlord shall either: (a) consent to the Transfer by execution of a consent agreement in a form reasonably designated by Landlord; (b) refuse to consent to the Transfer; (c) recapture the portion of the Premises that Tenant is
proposing to Transfer; or (d) elect to increase the Base Rent payable hereunder with respect to the portion of the Premises to be assigned or sublet to the Market Rent, as set forth below. If Landlord exercises its right to recapture, the Lease
shall automatically be amended to delete the applicable portion of the Premises effective on the proposed effective date of the Transfer. “Market Rent” shall mean the monthly amount per square foot in the Premises that
a willing, non-equity new tenant would pay and a willing landlord would accept at arm’s length for space in a comparable office park, with comparable tenant improvements, in a comparable location, giving
appropriate consideration to monthly rental rates per square foot, the presence or absence of rent escalation clauses such as operating expense and tax pass-throughs, length of lease term, size and location of premises being leased and other
generally applicable terms and conditions of tenancy for a similar office park. 
 12.02 Landlord and Tenant hereby acknowledge that
Landlord’s disapproval of any proposed Transfer pursuant to this Section will not be deemed unreasonably withheld if based upon any reasonable factor, including, without limitation, any or all of the following factors: (i) the portion of
the Premises to be sublet or assigned is irregular in shape with inadequate means of ingress and egress; (ii) the use of the Premises by the transferee (A) is not permitted by the use provisions in Section 4 hereof,
(B) violates any exclusive use granted by Landlord to another tenant in the Development, or (C) otherwise poses a risk of increased liability to Landlord; (iii) the Transfer would likely result in a significant and inappropriate
increase in the use of the parking areas or Common Areas by the transferee’s employees or visitors, and/or significantly increase the demand upon utilities and services to be provided by Landlord to the Premises; (iv) the Transferee does
not have the financial capability to fulfill the obligations imposed by the Transfer and this Lease; (v) the transferee is not in Landlord’s reasonable opinion consistent with Landlord’s desired tenant mix; or (vi) the transferee
poses a business or other economic risk which Landlord deems unacceptable. 
 12.03 Tenant hereby waives the provisions of
Section 1995.310 of the California Civil Code, or any similar or successor Laws, now or hereinafter in effect, and all other remedies, including, without limitation, any right at law or equity to terminate this Lease, on its own behalf and, to
the extent permitted under all applicable Laws, on behalf of the proposed transferee. In no event shall any Transfer release or relieve Tenant from any obligation under this Lease. Tenant shall pay Landlord a review fee of five hundred dollars
($500.00) for Landlord’s review of any requested Transfer. Additionally, Tenant shall reimburse Landlord for all reasonable attorneys’ fees and costs incurred by Landlord with respect to any Transfer, whether consented to or not. If Tenant
is in Default, Landlord may require that all sublease payments be made directly to Landlord, in which case Tenant shall receive a credit against Rent in the amount of Tenant’s share of payments received by Landlord. 

12.04 If Landlord consents to any Transfer, Tenant agrees to pay to Landlord, as Additional Rent, fifty percent (50%) of all sums and other
consideration actually paid to and for the benefit of Tenant by the transferee on account of the Transfer, as and when such sums and other consideration are paid by the transferee to or for the benefit of Tenant (or, if Landlord so requires, and
without any release of Tenant’s liability for the same, Tenant agrees to instruct the transferee to pay such sums and other consideration directly to Landlord). If for any Transfer, Tenant receives rent or other consideration, either initially
or over the term of the Transfer term, in excess of the rent fairly allocable to the portion of the Premises which is subleased based on square footage, Tenant agrees to pay to Landlord as Additional Rent fifty percent (50%) of the excess of each
such payment of rent or other consideration received by Tenant promptly after its receipt. In calculating excess rent or other consideration which may be payable to Landlord under this paragraph, Tenant will be entitled to deduct commercially
reasonable third party brokerage commissions and attorneys’ fees, tenant improvement construction costs and other amounts reasonably and actually expended by Tenant in connection with such assignment or subletting. Upon request, Tenant will
provide reasonable evidence of such expenditures to Landlord. 
 13. Liens. Tenant shall not permit mechanic’s or other liens to be placed upon
the Development or Premises in connection with any work purportedly done by or for the benefit of Tenant or its transferees. Tenant shall, within 10 days of notice from Landlord, fully discharge any lien by settlement, by bonding or by insuring over
the lien in the manner prescribed by Laws. If Tenant fails to do so, Landlord may bond, insure over or otherwise discharge the lien. Tenant shall reimburse Landlord for any amount paid by Landlord, including, without limitation, reasonable
attorneys’ fees. 

  
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 14. Indemnity and Waiver of Claims. Tenant hereby waives all claims against and releases Landlord and
its trustees, members, principals, beneficiaries, partners, officers, directors, employees, Mortgagees (as defined herein) and agents (the “Landlord Related Parties”) from all claims for any injury to or death of
persons, damage to property or business loss in any manner related to (a) acts of God, (b) acts of third parties, (c) the bursting or leaking of any tank, water closet, drain or other pipe; (d) the inadequacy or failure of any
security services, personnel or equipment, or (e) any matter outside of the reasonable control of Landlord. Except to the extent caused by the gross negligence or willful misconduct of Landlord or any Landlord Related Parties, Tenant shall
indemnify, defend and hold Landlord and Landlord Related Parties harmless against and from all liabilities, obligations, damages, penalties, claims, actions, costs, charges and expenses, including, without limitation, reasonable attorneys’ fees
and other professional fees (if and to the extent permitted by Laws), which may be imposed upon, incurred by or asserted against Landlord or any of the Landlord Related Parties by any third party and arising out of or in connection with any damage
or injury occurring in, on or about the Premises or any acts or omissions (including violations of Laws) of Tenant and its trustees, members, principals, beneficiaries, partners, officers, directors, employees, Mortgagees and agents (the
“Tenant Related Parties”) or any of Tenant’s transferees, contractors or licensees. Notwithstanding the provisions of this Section 14 above to the contrary, Tenant’s indemnity of Landlord and the
Landlord Related Parties shall not apply to: (i) any claims to the extent resulting from the gross negligence or willful misconduct of the Landlord Related Parties and not insured or required to be insured by Tenant under this Lease
(collectively, the “Excluded Claims”); or (ii) any loss of or damage to Landlord’s property to the extent Landlord has waived such loss or damage pursuant to Section 16 below. In addition,
Landlord shall indemnify, defend, protect and hold Tenant harmless from all such Excluded Claims, except for (A) any loss or damage to Tenant’s property to the extent Tenant has waived such loss or damage pursuant to Section 16
below, and (B) any lost profits, loss of business or other consequential damages. 
 15. Insurance. 

15.01 Tenant shall obtain and maintain throughout the Term the following insurance (“Tenant’s Insurance”): 

(a) Commercial General Liability Insurance written on an ISO CG 00 01 12 07 form or equivalent covering the insured against claims of bodily
injury, personal and advertising injury and property damage arising out of Tenant’s operations, assumed liabilities or use of the Premises, with no exclusion or limitation to the policy definition of “Insured Contract”, covering the
insuring provisions of this Lease and the performance by Tenant of the indemnity agreements set forth in Section 14 of this Lease, and liquor liability coverage (in the event alcoholic beverages are served on the Premises) for limits of
liability not less than: 
  

			
	Bodily Injury and	  	$2,000,000.00 each occurrence
	Property Damage Liability	  	$2,000,000.00 general aggregate
		  	$2,000,000.00 Products/Completed Operations Aggregate
		
	Personal and Advertising Injury Liability	  	$2,000,000.00 each occurrence
		  	(included in general aggregate)
		  	0% Insured’s participation

 (b) Property Insurance, written on “Special Form Cause of Loss Perils form, with coverage for broad form
water damage including earthquake sprinkler leakage and pollution coverage for damage caused by heat, smoke or fumes from a hostile fire, at full replacement cost value (without deduction for depreciation) and with a replacement cost endorsement
covering all of Tenant’s business and trade fixtures, equipment, movable partitions, furniture, merchandise and other personal property, including property of others for which the tenant may be legally liable, within the Premises
(“Tenant’s Property”) and any Leasehold Improvements performed by or for the benefit of Tenant; 

  
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 (c)
Loss-of-income, business interruption and extra-expense insurance in such amounts as will reimburse Tenant for direct and indirect loss of earnings attributable to all
perils commonly insured against by prudent tenants or attributable to prevention of loss of access to the Premises or to the Building as a result of such perils. 

(d) Workers’ Compensation Insurance as required by laws and in amounts as may be required by applicable statute and Employers Liability
Coverage of at least $1,000,000 each accident, $1,000,000.00 policy limit, $1,000,000.00 each employee, and containing a waiver of subrogation endorsement in favor of Landlord; 

(e) If and to the extent Tenant or its employees drive automobiles or other motor vehicles in the course of conducting Tenant’s business,
Commercial Automobile Liability insuring bodily injury and property damage arising from all owned, non-owned and hired vehicles, if any, with minimum limits of liability of $1,000,000.00 combined single limit,
each accident; and 
 (f) With respect to improvements or Alterations performed by or on behalf of Tenant within the Premises, Builder’s
Risk insurance or an Installation Floater covering the full amount of the work to be performed, subject to Special Form Cause of Loss perils; provided, however, that in lieu of this requirement, Tenant may cause its general contractor to maintain
the foregoing coverage. Such insurance will name the Landlord and Tenant, and, if applicable, the Contractor and Subcontractors, as Insureds. 

15.02 Any company writing Tenant’s Insurance shall have an A.M. Best rating of not less than A: VIII and shall be licensed to issue
insurance coverage in the state in which the premises are located. All Commercial General Liability Insurance policies shall (i) name Landlord (or its successors and assignees), the managing agent for the Building (or any successor), and their
respective members, principals, beneficiaries, partners, officers, directors, employees, and agents, and other designees of Landlord and its successors as the interest of such designees shall appear, as additional insureds (utilizing endorsement ISO
Form CG 2011 11/85 or equivalent, for tenant improvements or betterments requiring structural alterations the contractors performing the work will provide additional insured endorsements utilizing a combination of the forms CG 20 10 07/04 and CG 20
37 07/04 in favor of the stated additional insureds), (ii) must contain an endorsement stating “such insurance as is afforded by this policy for the benefit of Landlord and any other additional insured(s) designated by Landlord, shall be
primary as respects any liability or claims arising out of the occupancy of the Premises by Tenant or Tenant’s operations, and any insurance carried by Landlord or any other additional insured(s) shall be
non-contributory” (iii) contain an endorsement that the insurer waives its right to subrogation as described in Section 16 below; (iv) contain a cross-liability endorsement or
separation of insureds clause. Tenant shall endeavor to obtain the agreement of the insurer writing Tenant’s Insurance to notify Landlord (and any other additional insureds) in writing not less than thirty (30) days prior to any
cancellation, termination, material change or lapse of Tenant’s Insurance (it being agreed that efforts by Tenant to obtain such an agreement by the insurer shall include obtaining any commercially available endorsement to assure such
notification). In addition to the foregoing, Tenant shall notify Landlord (and any other additional insureds) in writing not less than thirty (30) days prior to any cancellation, termination, material change or lapse of Tenant’s Insurance.
Tenant shall provide Landlord with a certificate of insurance evidencing all insurance required to be carried by Tenant hereunder (including evidence of all required endorsements and additional insured coverage as noted above) at least fifteen
(15) days prior to the earlier to occur of the Commencement Date or the date Tenant is provided with possession of the Premises, and thereafter as necessary to assure that Landlord always has current certificates evidencing Tenant’s
Insurance. If any such initial or replacement policies or certificates are not furnished within the time(s) specified herein, Tenant shall be deemed to be in material Default under this Lease without the benefit of any additional notice or cure
period provided in Section 19 below, and Landlord shall have the right, but not the obligation, to procure such policies and certificates at Tenant’s expense, and Tenant shall pay the cost thereof within ten (10) days following
Landlord’s submission of an invoice therefor. In no event shall the limits of any insurance policy obtained by a Tenant be considered to limit the liability of Tenant under this Lease. 

16. Subrogation. Landlord and Tenant hereby waive and shall cause their respective insurance carriers to waive any and all rights of recovery, claims,
actions or causes of action against the other for any loss or damage to person with respect to Tenant’s Property, Leasehold Improvements, the Building, the Premises, or any contents thereof, including rights, claims, actions and causes of
action based on negligence, which loss, damage or injury is (or would have been, had the insurance required by this Lease been carried) covered by insurance. As noted above, Tenant also waives subrogation with respect to losses or claims covered by
worker’s compensation insurance. 

  
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 17. Casualty Damage. Landlord, by notice to Tenant within sixty (60) days of the date of the
fire or other casualty (a “Casualty”), shall have the right to terminate this Lease if all or any part of the Premises is damaged to the extent that it cannot reasonably be repaired within one hundred twenty (120) days after
the date of the Casualty. If this Lease is not terminated, Landlord shall promptly and diligently, restore the Premises. Such restoration shall be to substantially the same condition that existed prior to the Casualty, except for modifications
required by Laws. Upon notice from Landlord, Tenant shall assign to Landlord (or to any party designated by Landlord) all property insurance proceeds payable to Tenant under Tenant’s Insurance with respect to any Leasehold Improvements
performed by or for the benefit of Tenant; provided if the estimated cost to repair such Leasehold Improvements exceeds the amount of insurance proceeds received by Landlord from Tenant’s insurance carrier, the excess cost of such
repairs shall be paid by Tenant to Landlord prior to Landlord’s commencement of repairs. Within thirty (30) days of demand, Tenant shall also pay Landlord for any additional excess costs relating to Leasehold Improvements that are
determined during the performance of the repairs. Landlord shall not be liable for any inconvenience to Tenant, or injury to Tenant’s business resulting in any way from the Casualty or the repair thereof. Provided that Tenant is not in
Default, during any period of time that all or a material portion of the Premises is rendered untenantable as a result of a Casualty, the Rent shall abate for the portion of the Premises that is untenantable and not used by Tenant. Notwithstanding
the foregoing, and without limiting Tenant’s obligations, to pay to Landlord any cost of restoration of the Leasehold Improvements in excess of the proceeds of Tenant’s Insurance, in the event that Landlord does not receive sufficient
insurance proceeds to complete all required restoration work, whether due to an uninsured Casualty, requirements of a Mortgagee, or otherwise, then Landlord shall have the right to terminate this Lease by written notice to Tenant. The provisions of
this Lease, including this Section 17, constitute an express agreement between Landlord and Tenant with respect to any and all damage to, or destruction of, all or any part of the Premises, the Building, or the Development, and any Laws,
including, without limitation, Sections 1932(2) and 1933(4) of the California Civil Code, with respect to any rights or obligations concerning damage or destruction in the absence of an express agreement between the parties, and any similar or
successor Laws now or hereinafter in effect, shall have no application to this Lease or any damage or destruction to all or any part of the Premises, the Building or the Development. 

18. Condemnation. Either party may terminate this Lease if any material part of the Premises is taken or condemned for, or rendered unusable in a manner
consistent with the Permitted Use due to a taking for, any public or quasi-public use under Laws, by eminent domain or private purchase in lieu thereof (a “Taking”). Landlord shall also have the right to terminate this Lease if
there is a Taking of any portion of the Building or Property which would have a material adverse effect on Landlord’s ability to profitably operate the remainder of the Building. The terminating party shall provide written notice of termination
to the other party within forty-five (45) days after it first receives notice of the Taking. The termination shall be effective on the date the physical taking occurs. All compensation awarded for a Taking, or sale proceeds, shall be the
property of Landlord. Tenant hereby waives any and all rights it might otherwise have pursuant to Section 1265.130 of the California Code of Civil Procedure, or any similar or successor Laws. 

19. Events of Default. Each of the following occurrences shall be considered to be a “Default”: (a) Tenant’s failure to pay any
portion of Rent when due, if the failure continues for three (3) days after written notice to Tenant, which notice shall be in satisfaction of, and not in addition to, notice required by Laws (“Monetary Default”);
or (b) Tenant’s failure (other than a Monetary Default) to comply with any term, provision, condition or covenant of this Lease, if the failure is not cured within ten (10) days after written notice to Tenant, which notice shall be in
satisfaction of, and not in addition to, notice required by Laws (including, without limitation, Section 1161 of the California Code of Civil Procedure), provided, however, if Tenant’s failure to comply cannot reasonably be
cured within ten (10) days, Tenant shall be allowed additional time (not to exceed sixty (60) days) as is reasonably necessary to cure the failure so long as Tenant commences to cure within ten (10) days and Tenant diligently pursues
the cure to completion. 
 20. Remedies. 

20.01 Upon the occurrence of any Default under this Lease, whether enumerated in Section 19 above or not, Landlord shall have the
option to pursue any one (1) or more of the following remedies without any notice (except as expressly prescribed herein) or demand whatsoever (and without limiting the generality of the foregoing, Tenant hereby specifically waives notice and
demand for payment of Rent or other obligations, except for those notices specifically required pursuant to the terms of Section 19 above or this Section 20, and waives any and all other notices or demand requirements imposed
by applicable law): 

  
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 (a) Terminate this Lease and Tenant’s right to possession of the Premises and recover
from Tenant an award of damages equal to the sum of the following: 
 (i) The Worth at the Time of Award (as defined below) of the unpaid
Rent which had been earned at the time of termination; 
 (ii) The Worth at the Time of Award of the amount by which the unpaid Rent which
would have been earned after termination until the time of award exceeds the amount of such Rent loss that Tenant affirmatively proves could have been reasonably avoided; 

(iii) The Worth at the Time of Award of the amount by which the unpaid Rent for the balance of the Term after the time of award exceeds the
amount of such Rent loss that Tenant affirmatively proves could be reasonably avoided; 
 (iv) Any other amount necessary to compensate
Landlord for all the detriment either proximately caused by Tenant’s failure to perform Tenant’s obligations under this Lease or which in the ordinary course of things would be likely to result therefrom; and 

(v) All such other amounts in addition to or in lieu of the foregoing as may be permitted from time to time under applicable law. 

The “Worth at the Time of Award” of the amounts referred to in parts (i) and (ii) above, shall be computed by
allowing interest at the lesser of a per annum rate equal to: (A) the greatest per annum rate of interest permitted from time to time under applicable law, or (B) the Prime Rate (defined below) plus five percent (5%) (the
“Interest Rate”). For purposes hereof, the “Prime Rate” shall be the per annum interest rate publicly announced as its prime or base rate by a federally insured bank selected by Landlord in the
State of California. The “Worth at the Time of Award” of the amount referred to in part (iii), above, shall be computed by discounting such amount at the discount rate of the Federal Reserve Bank of San Francisco at the time
of award plus one percent (1%); 
 (b) Employ the remedy described in California Civil Code § 1951.4 (Landlord may continue this Lease
in effect after Tenant’s breach and abandonment and recover Rent as it becomes due, if Tenant has the right to sublet or assign, subject only to reasonable limitations); or 

(c) Notwithstanding Landlord’s exercise of the remedy described in California Civil Code § 1951.4 in respect of an event or events of
Default, at such time thereafter as Landlord may elect in writing, to terminate this Lease and Tenant’s right to possession of the Premises and recover an award of damages as provided above in Section 20.01(a). 

20.02 The subsequent acceptance of Rent hereunder by Landlord shall not be deemed to be a waiver of any preceding breach by Tenant of any term,
covenant or condition of this Lease, other than the failure of Tenant to pay the particular Rent so accepted, regardless of Landlord’s knowledge of such preceding breach at the time of acceptance of such Rent. No waiver by Landlord of any
breach hereof shall be effective unless such waiver is in writing and signed by Landlord. 
 20.03 TENANT HEREBY WAIVES ANY AND ALL RIGHTS
CONFERRED BY SECTION 3275 OF THE CIVIL CODE OF CALIFORNIA AND BY SECTIONS 1174 (c) AND 1179 OF THE CODE OF CIVIL PROCEDURE OF CALIFORNIA AND ANY AND ALL OTHER LAWS AND RULES OF LAW FROM TIME TO TIME IN EFFECT DURING THE LEASE TERM PROVIDING THAT
TENANT SHALL HAVE ANY RIGHT TO REDEEM, REINSTATE OR RESTORE THIS LEASE FOLLOWING ITS TERMINATION BY REASON OF TENANT’S BREACH. TENANT ALSO HEREBY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, THE RIGHT TO TRIAL BY JURY IN ANY LITIGATION
ARISING OUT OF OR RELATING TO THIS LEASE. 
 20.04 No right or remedy herein conferred upon or reserved to Landlord is intended to be
exclusive of any other right or remedy, and each and every right and remedy shall be cumulative and in addition to any other right or remedy given hereunder or now or hereafter existing by agreement, applicable law or in equity. In addition to other
remedies provided in this Lease, Landlord shall be entitled, to the extent permitted by applicable law, to injunctive relief, or to a decree compelling performance of any of the covenants, agreements, conditions or provisions of this Lease, or to
any other remedy allowed to Landlord at law or in equity. Forbearance by Landlord to enforce one or more of the remedies herein provided upon an event of Default shall not be deemed or construed to constitute a waiver of such Default. 

  
 -14- 

 20.05 If Tenant is in Default of any of its
non-monetary obligations under this Lease, Landlord shall have the right to perform such obligations. Tenant shall reimburse Landlord for the cost of such performance upon demand together with an
administrative charge equal to ten percent (10%) of the cost of the work performed by Landlord. 
 20.06 This Section 20 shall be
enforceable to the maximum extent such enforcement is not prohibited by applicable law, and the unenforceability of any portion thereof shall not thereby render unenforceable any other portion. 

21. Limitation of Liability. 
 THE
LIABILITY OF LANDLORD (AND OF ANY SUCCESSOR LANDLORD) SHALL BE LIMITED TO THE LESSER OF (A) THE INTEREST OF LANDLORD IN THE PROPERTY, OR (B) THE EQUITY INTEREST LANDLORD WOULD HAVE IN THE PROPERTY IF THE PROPERTY WERE ENCUMBERED BY THIRD
PARTY DEBT IN AN AMOUNT EQUAL TO SEVENTY PERCENT (70%) OF THE VALUE OF THE PROPERTY. TENANT SHALL LOOK SOLELY TO LANDLORD’S INTEREST IN THE PROPERTY FOR THE RECOVERY OF ANY JUDGMENT OR AWARD AGAINST LANDLORD OR ANY LANDLORD RELATED PARTY.
NEITHER LANDLORD NOR ANY LANDLORD RELATED PARTY SHALL BE PERSONALLY LIABLE FOR ANY JUDGMENT OR DEFICIENCY AND IN NO EVENT SHALL LANDLORD OR ANY LANDLORD RELATED PARTY BE LIABLE TO TENANT FOR ANY LOST PROFIT, DAMAGE TO OR LOSS OF BUSINESS OR ANY FORM
OF SPECIAL, INDIRECT OR CONSEQUENTIAL DAMAGE. BEFORE FILING SUIT FOR AN ALLEGED DEFAULT BY LANDLORD, TENANT SHALL GIVE LANDLORD AND THE MORTGAGEE(S) (DEFINED IN SECTION 24 BELOW) WHOM TENANT HAS BEEN NOTIFIED HOLD MORTGAGES (DEFINED IN
SECTION 24 BELOW), NOTICE AND REASONABLE TIME TO CURE THE ALLEGED DEFAULT. 
 22. Intentionally Omitted. 

23. Holding Over. If Tenant remains in possession of the Premises after expiration or termination of the Term, or after the date in any notice given by
Landlord to Tenant terminating this Lease, such possession by Tenant shall be deemed to be a month-to-month tenancy terminable on written thirty (30) day notice at
any time, by either party. Tenant’s occupancy shall be subject to all the terms and provisions of this Lease and Tenant shall pay an amount (on a per month basis without reduction for partial months during the holdover) equal to one hundred
fifty percent (150%) of the fair market gross rental for the Premises as reasonably determined by Landlord (which in no event shall be less than one hundred fifty percent (150%) of the sum of the Base Rent and Additional Rent due for the period
immediately preceding the holdover). No holdover by Tenant or payment by Tenant after the termination of this Lease shall be construed to extend the Term or prevent Landlord from immediate recovery of possession of the Premises by summary
proceedings or otherwise. If Tenant fails to surrender the Premises upon the termination or expiration of this Lease, in addition to any other liabilities to Landlord accruing therefrom, Tenant shall protect, defend, indemnify and hold Landlord
harmless from all loss, costs (including reasonable attorneys’ fees) and liability resulting from such failure, including any claims made by any succeeding tenant founded upon such failure to surrender, and any lost profits to Landlord
resulting therefrom. 
 24. Subordination to Mortgages; Estoppel Certificate. Tenant accepts this Lease subject and subordinate to any mortgage(s),
deed(s) of trust, ground lease(s) or other lien(s) now or subsequently arising upon the Premises, the Building or the Development, and to renewals, modifications, refinancings and extensions thereof (collectively referred to as a
“Mortgage”). This clause shall be self-operative, but upon request from the holder of a Mortgage (a “Mortgagee”), Tenant shall execute a commercially reasonable subordination agreement. As an alternative, a
Mortgagee shall have the right at any time to subordinate its Mortgage to this Lease. Upon request, Tenant shall, without charge, attorn to any successor to Landlord’s interest in this Lease. Tenant shall, within ten (10) days after
receipt of a written request from Landlord, execute and deliver a commercially reasonable estoppel certificate to those parties as are reasonably requested by Landlord. 

25. Financial Statements. Prior to the execution of this Lease by Landlord and at any time during the Term of this Lease (unless Tenant has become a
public reporting company under the Securities Exchange Act of 1934) upon ten (10) days prior written notice from Landlord, Tenant agrees to provide Landlord with a current financial statement for Tenant and any guarantors of Tenant and
financial statements for the two (2) years prior to the current financial statement year for Tenant and any guarantors of Tenant. Such statements are to be prepared in accordance with generally accepted accounting principles and, if such is the
normal practice of Tenant, audited by an independent certified public accountant. 

  
 -15- 

 26. Notice. All demands, approvals, consents or notices shall be in writing and delivered by hand or
sent by registered or certified mail with return receipt requested, or sent by overnight or same day courier service at the party’s respective Notice Address(es) set forth in Section 1 above. Each notice shall be deemed to have been
received on the earlier to occur of actual delivery or the date on which delivery is refused, or, if Tenant has vacated the Premises or any other Notice Address without providing a new Notice Address, three (3) days after notice is deposited in
the U.S. mail or with a courier service in the manner described above. Either party may, at any time, change its Notice Address (other than to a post office box address) by giving the other party written notice of the new address. 

27. Surrender of Premises. At the termination of this Lease or Tenant’s right of possession, Tenant shall remove Tenant’s Property and any
designated Required Removables from the Premises, and quit and surrender the Premises to Landlord, broom clean, and in good order, condition and repair, ordinary wear and tear and damage which Landlord is obligated to repair hereunder excepted. If
Tenant fails to remove any of Tenant’s Property within two (2) days after termination, Landlord, at Tenant’s sole cost and expense, shall be entitled to remove and store Tenant’s Property. Landlord shall not be responsible for
the value, preservation or safekeeping of Tenant’s Property. Tenant shall pay Landlord, upon demand, the expenses and storage charges incurred. If Tenant fails to remove Tenant’s Property from the Premises or storage within thirty
(30) days after notice, Landlord may deem all or any part of Tenant’s Property to be abandoned and title to Tenant’s Property shall vest in Landlord. If Tenant fails to remove any of the designated Required Removables by the
Expiration Date or perform related repairs in a timely manner, Landlord may perform such work at Tenant’s expense, and Tenant shall be deemed to be in holdover of the Premises pursuant to Section 23 above during the reasonable
period of time required for the removal of Tenant’s Property. 
 28. Miscellaneous. 

28.01 Costs and Expenses; No Waiver. If either party institutes a suit against the other for violation of or to enforce any covenant,
term or condition of this Lease, the prevailing party shall be entitled to all of its costs and expenses, including, without limitation, reasonable attorneys’ fees. Landlord and Tenant hereby waive any right to trial by jury in any proceeding
based upon a breach of this Lease. Either party’s failure to declare a default immediately upon its occurrence, or delay in taking action for a default shall not constitute a waiver of the default, nor shall it constitute an estoppel. 

28.02 Force Majeure. Whenever a period of time is prescribed for the taking of an action by Landlord or Tenant (other than the payment
of the Security Deposit or Rent), the period of time for the performance of such action shall be extended by the number of days that the performance is actually delayed due to strikes, acts of God, shortages of labor or materials, war, terrorist
acts, civil disturbances and other causes beyond the reasonable control of the performing party (“Force Majeure”). Force Majeure shall not include financial difficulties of the party required to perform. 

28.03 Transfer By Landlord. Landlord shall have the right to transfer and assign, in whole or in part, all of its ownership interest,
rights and obligations in the Building, Development or Lease, including the Security Deposit, and upon transfer Landlord shall be released from any further obligations hereunder, and Tenant agrees to look solely to the successor in interest of
Landlord for the performance of such obligations and the return of any Security Deposit. 
 28.04 Submission of Lease; Claims By
Brokers. Landlord has delivered a copy of this Lease to Tenant for Tenant’s review only, and the delivery of it does not constitute an offer to Tenant or an option. Tenant represents that it has dealt directly with and only with the Broker
as a broker in connection with this Lease. Tenant shall indemnify and hold Landlord and the Landlord Related Parties harmless from all claims of any other brokers claiming to have represented Tenant in connection with this Lease. 

28.05 Survival of Obligations. The expiration of the Term, whether by lapse of time, termination or otherwise, shall not relieve either
party of any obligations which accrued prior to or which may continue to accrue after the expiration or termination of this Lease. 

  
 -16- 

 28.06 Quiet Enjoyment; Binding Covenants. Tenant shall, and may peacefully have, hold
and enjoy the Premises, subject to the terms of this Lease, provided Tenant pays the Rent and fully performs all of its covenants and agreements. This covenant and all other covenants of Landlord shall be binding upon Landlord and its successors
only during its or their respective periods of ownership of the Building. 
 28.07 Entire Agreement. This Lease constitutes the entire
agreement between the parties and supersedes all prior agreements and understandings related to the Premises. This Lease may be modified only by a written agreement signed by Landlord and Tenant. This Lease shall be interpreted and enforced in
accordance with the Laws of the state or commonwealth in which the Building is located. 
 28.08 Authority; PATRIOT Act. Tenant
represents and warrants to Landlord that each individual executing this Lease on behalf of Tenant is authorized to do so on behalf of Tenant and that Tenant is not, and the entities or individuals constituting Tenant or which may own or control
Tenant or which may be owned or controlled by Tenant are not, among the individuals or entities identified on any list compiled pursuant to Executive Order 13224 for the purpose of identifying suspected terrorists. 

28.09 Time is of the Essence. Time is of the essence with respect to the performance of every provision of this Lease in which time of
performance is a factor. 
 28.10 Severability. The provisions of this Lease shall be considered separable such that if any provision
or part of this Lease is ever held to be invalid, void or illegal under any law or ruling, all remaining provisions of this Lease shall remain in full force and effect to the maximum extent permitted by law. 

28.11 Confidentiality. The parties acknowledge and agree that the terms of this Lease are confidential and constitute proprietary
information. Disclosure of the terms could adversely affect the ability of Landlord to negotiate other leases and impair Landlord’s relationship with other tenants. Accordingly, the parties agree that they, and their respective partners,
officers, directors, employees, agents and attorneys, shall not intentionally and voluntarily disclose the terms and conditions of this Lease to any newspaper or other publication or any other tenant or apparent prospective tenant of the Building or
other portion of the Development, or real estate agent, either directly or indirectly, without the prior written consent of the other party, provided, however, that Tenant may disclose the terms to prospective subtenants or assignees
under this Lease. 
 29. Parking. 
 29.01
Tenant’s Parking. During the Term of this Lease, Tenant shall have the right to use, at no charge to Tenant during the initial Term, the number of parking spaces specified in Section 1.11 of the Basic Lease Information
hereof, for use by Tenant’s employees in the common parking areas for the Building within the Development, as designated by Landlord from time to time. Landlord shall at all times have the right to establish and modify the nature and extent of
the parking areas for the Building and Development (including whether such areas shall be surface, underground and/or other structures) as long as Tenant is provided the number of parking spaces designated in the Basic Lease Information. In
addition, Landlord may, in its sole discretion, assign any unreserved and unassigned parking spaces, and/or make all or a portion of such spaces reserved. 

29.02 In addition to such parking spaces for use by Tenant’s employees, Landlord shall permit access to the parking areas for
Tenant’s visitors, subject to availability of spaces and payment (by validation charges or otherwise) of daily visitor parking charges therefor as may be established and adjusted by Landlord from time to time. Landlord hereby agrees to provide
three (3) additional unreserved parking spaces adjacent to the Building, for the non-exclusive use of all visitors and invitees of the Building or Development. Landlord shall use commercially reasonable
efforts to identify such three (3) stalls in a location near the entrance of the Building for use by visitors of the Building or Development, which stalls are subject to relocation in Landlord’s sole and absolute discretion. Although there
are currently no daily visitor parking charges, Landlord reserves the right to impose such charges in the future. To the extent Landlord institutes any visitor parking charges, Landlord shall provide Tenant the ability to validate its visitors
parking, such that they will not be responsible for payment of such charges. 
 29.03 The use of the parking areas shall be subject to any
reasonable, non-discriminatory rules and regulations adopted by Landlord and/or Landlord’s parking operators from time to time, including any system for controlled ingress and egress and charging visitors
and invitees, with appropriate provision for validation of such charges. Tenant shall not use more parking spaces than its allotment and shall not use any parking spaces specifically assigned by Landlord to other tenants of the Building or
Development or for such other uses as visitor 

  
 -17- 

 parking. Tenant’s parking spaces shall be used only for parking by vehicles no larger than normally
sized passenger automobiles or pick-up trucks. Tenant shall not permit or allow any vehicles that belong to or are controlled by Tenant or Tenant’s employees, suppliers, shippers, customers or invitees to
be loaded, unloaded, or parked in areas other than those designated by Landlord for such activities. If Tenant permits or allows any of the prohibited activities described herein, including, without limitation, parking in spaces designated as
reserved spaces, illegal parking, and any non-compliance with posted signage, then Landlord shall have the right, without notice, in addition to such other rights and remedies that it may have, to remove or
tow away the vehicle involved and charge the cost thereof to Tenant, which cost shall be immediately payable by Tenant upon demand by Landlord. 

29.04 Subject to plans and specifications approved in advance by Landlord, including designation of the parking space to be used and paid for
by Tenant in connection therewith, and in accordance with the terms and conditions set forth in Section 10.02 above, Tenant shall have the right to install at its sole cost and expense an electric vehicle charging station for use by
Tenant’s employees. Tenant shall be solely responsible for acquisition and installation of the charging station and all associated infrastructure and shall arrange and pay for electricity and any metering to measure the electricity utilized by
the charging station. Tenant shall be responsible to obtain and maintain all permits required for the installation, operation and maintenance of the charging station in compliance with all applicable laws, rules and regulations. Upon Landlord or
Tenant’s request, prior to installation of the charging station, Landlord and Tenant shall enter into a lease amendment, or other written agreement, in mutually acceptable form to set forth the terms and conditions governing the charging
station. At the expiration or earlier termination of the Lease, Tenant shall, upon Landlord’s request, remove the charging station from the Development (and shall repair any damage caused by such removal), but shall leave all associated
infrastructure in place. 
 30. Intentionally Omitted. 

31. Counterparts; Electronic Delivery /Signatures. This Lease may be executed in one or more counterparts, each of which shall constitute an original
and all of which shall be one and the same agreement. The parties may exchange electronic counterpart signatures by facsimile or electronic transmission and the same shall constitute execution and delivery of this Lease with respect to the
delivering party. If a variation or discrepancy among counterparts occurs, the copy of this Lease in Landlord’s possession shall control. 
 32.
Hazardous Materials. 
 32.01 Tenant will (i) obtain and maintain in full force and effect all Environmental Permits (defined below)
that may be required from time to time under any Environmental Laws (defined below) applicable to Tenant or the Premises and (ii) be and remain in compliance in all material respects with all terms and conditions of all such Environmental
Permits and with all other limitations, restrictions, conditions, standards, prohibitions, requirements, obligations, schedules and timetables contained in all Environmental Laws applicable to Tenant or to Tenant’s operations in the Premises.
As used in this Lease, the term “Environmental Laws” means any past, present or future federal, state, local or foreign statutory or common law, or any regulation, ordinance, code, plan, order, permit, grant,
franchise, concession, restriction or agreement issued, entered, promulgated or approved thereunder, relating to (a) the environment, human health or safety, including, without limitation, emissions, discharges, releases or threatened releases
of Hazardous Materials (as defined below) into the environment (including, without limitation, air, surface water, groundwater or land), or (b) the manufacture, generation, refining, processing, distribution, use, sale, treatment, receipt,
storage, disposal, transport, arranging for transport, or handling of Hazardous Materials. “Environmental Permits” means, collectively, any and all permits, consents, licenses, approvals and registrations of any nature at any
time required pursuant to, or in order to comply with, any Environmental Laws. Except for ordinary and general office supplies, equipment and facilities, such as copier toner, liquid paper, back-up power
sources, glue, ink and common household cleaning materials, as well as customary quantities of first aid supplies and the parking of vehicles in the parking areas adjacent to the Premises (some or all of which may constitute “Hazardous
Materials” as defined in this Lease), Tenant agrees not to cause or knowingly permit any Hazardous Materials to be brought upon, stored, used, handled, generated, released or disposed of on, in, under or about the Premises, the Building, the
Development or any portion thereof by Tenant or any of Tenant’s Parties (as defined in Section 1.11 hereof) without the prior written consent of Landlord, which consent Landlord may withhold in its sole and absolute discretion. Upon
the expiration or earlier termination of this Lease, Tenant agrees to promptly remove from the Premises, at its sole cost and expense, any and all Hazardous Materials, including any equipment or systems containing Hazardous Materials which are
installed, brought upon, stored, used, generated or released upon, in, under or about the Premises, the Building, the Development or any portion thereof by Tenant or any of Tenant’s Parties. To the fullest extent permitted by law, Tenant agrees
to 

  
 -18- 

 promptly indemnify, protect, defend and hold harmless Landlord and Landlord’s partners, officers,
directors, employees, agents, successors and assigns (collectively, “Landlord Indemnified Parties”) from and against any and all claims, damages, judgments, suits, causes of action, losses, liabilities, penalties,
fines, expenses and costs (including, without limitation, clean-up, removal, remediation and restoration costs, sums paid in settlement of claims, attorneys’ fees, consultant fees and expert fees and
court costs) which arise or result from the presence of Hazardous Materials on, in, under or about the Premises, the Building or any other portion of the Development and which are caused or knowingly permitted by Tenant or any of Tenant’s
Parties. Tenant agrees to promptly notify Landlord of any release of Hazardous Materials at the Premises, which Tenant becomes aware of during the Term of this Lease, whether caused by Tenant or any other persons or entities. In the event of any
release of Hazardous Materials caused or permitted by Tenant or any of Tenant’s Parties, Landlord shall have the right, but not the obligation, to cause Tenant to immediately take all steps Landlord deems necessary or appropriate to remediate
such release and prevent any similar future release to the satisfaction of Landlord and Landlord’s mortgagee(s). As used in this Lease, the term “Hazardous Materials” shall mean and include any hazardous or toxic
materials, substances or wastes as now or hereafter designated under any law, statute, ordinance, rule, regulation, order or ruling of any agency of the State, the United States Government or any local governmental authority, including, without
limitation, asbestos, asbestos-containing material, presumed asbestos containing materials, petroleum, petroleum hydrocarbons and petroleum based products, urea formaldehyde foam insulation, polychlorinated biphenyls, and freon and other
chlorofluorocarbons. The provisions of this Section 32 will survive the expiration or earlier termination of this Lease. Tenant’s “cleanup” and remediation obligations shall not extend to items which are ordinarily
included in ordinary maintenance of the parking and loading areas within the Common Areas. 
 32.02 Subject to Sections 16 and
21 hereof, Landlord shall promptly indemnify, protect, defend and hold Tenant and Tenant’s partners, officers, directors, employees, agents, successors and assigns harmless from and against any and all claims, judgment, damages, suits,
causes of action, penalties, fines, expenses and costs, liabilities or losses (including, without limitation, sums paid in settlement of claims, attorneys’ fees, consultant fees and expert fees) (collectively, “Claims”) which
arise on or after the date that possession of the Premises is delivered to Tenant, including any time after the expiration of the Lease Term, from or in connection with Hazardous Materials conditions which were caused or knowingly permitted by
Landlord or its agents or employees. 
 33. Required Accessibility Disclosure. Landlord hereby advises Tenant that the Development has not
undergone an inspection by a certified access specialist, and except to the extent expressly set forth in this Lease, Landlord shall have no liability or responsibility to make any repairs or modifications to the Premises or the Development in order
to comply with accessibility standards. The following disclosure is hereby made pursuant to applicable California law: 
 “A Certified
Access Specialist (CASp) can inspect the subject premises and determine whether the subject premises comply with all of the applicable construction-related accessibility standards under state law. Although state law does not require a CASp
inspection of the subject premises, the commercial property owner or lessor may not prohibit the lessee or tenant from obtaining a CASp inspection of the subject premises for the occupancy or potential occupancy of the lessee or tenant, if requested
by the lessee or tenant. The parties shall mutually agree on the arrangements for the time and manner of the CASp inspection, the payment of the fee for the CASp inspection, and the cost of making any repairs necessary to correct violations of
construction-related accessibility standards within the premises.” [Cal. Civ. Code Section 1938(e)]. 
 Any CASp
inspection shall be conducted in compliance with reasonable rules in effect at the Building with regard to such inspections and shall be subject to Landlord’s prior written consent. 

[LANDLORD’S SIGNATURE ON PAGE S-1 AND TENANT’S SIGNATURE ON PAGE
S-2 ATTACHED HERETO] 
  

  
 -19- 

 Landlord has executed this Lease as of the day and year first above written. 

 

							
	LANDLORD:	 	
	
	 BIXBY SPE FINANCE 11, LLC,
 a
Delaware limited liability company

		
	By:	 	Bixby SPE Finance, LLC,
		 	a Delaware limited liability company
		 	its sole Member and Manager
			
		 	By:	 	Bixby Land Company,
		 		 	a California corporation
		 		 	its sole Member and Manager
				
		 		 	By:	 	 /s/ Aaron D. Hill

		 		 	Name:	 	Aaron D. Hill
		 		 	Title:	 	Executive Vice President and Chief Operating Officer
				
		 		 	By:	 	 /s/ Martin T. O’Hea

		 		 	Name:	 	Martin T. O’Hea
		 		 	Title:	 	Executive Vice President and CFO

 [TENANT’S SIGNATURE ON NEXT PAGE] 

  
 S-1 

 Tenant has executed this Lease as of the day and year first above written. 

 

			
	TENANT:
	
	 SI-BONE, INC.,

a Delaware corporation

		
	By:	 	 /s/ Jeffrey W. Dunn

	Name:	 	Jeffrey W. Dunn
	Title:	 	President, CEO and Chairman
		
	By:	 	 /s/ Michael Pisetsky

	Name:	 	Michael Pisetsky
	Title:	 	VP & General Counsel
		
		 	        26-2216351
	  
 Tenant’s Tax ID
Number (SSN or FEIN)

  
 S-2 

 EXHIBIT A 

OUTLINE AND LOCATION OF PREMISES 

This Exhibit is attached to and made a part of the Lease by and between BIXBY SPE FINANCE 11, LLC, a Delaware limited liability company
(“Landlord”) and SI-BONE, INC., a Delaware corporation (“Tenant”) for space in the Building located at 471 El Camino Real, Santa Clara, California. 

 
 

 
 Exhibit A is intended only to show the general layout of the space Plan as of the beginning of the Term of this
Lease. It does not in any way supersede any of Landlord’s rights with respect to arrangements and/or locations of public parts of the Building and changes in such arrangements and/or locations. It is not to scale; any measurements or distances
shown should be taken as approximate. 

  
 EXHIBIT A 

-1- 

 EXHIBIT A-1 

DEPICTION OF DEVELOPMENT 

This Exhibit is attached to and made a part of the Lease by and between BIXBY SPE FINANCE 11, LLC, a Delaware limited liability company
(“Landlord”) and SI-BONE, INC., a Delaware corporation (“Tenant”) for space in the Building located at 471 El Camino Real, Santa Clara, California. 

 
 

 

  
 EXHIBIT A-1 

-1- 

 EXHIBIT B 

OPERATING EXPENSES AND TAXES 

This Exhibit is attached to and made a part of the Lease by and between BIXBY SPE FINANCE 11, LLC, a Delaware limited liability company
(“Landlord”) and SI-BONE, INC., a Delaware corporation (“Tenant”) for space in the Building located at 471 El Camino Real, Santa Clara, California. 

1. Items Included in Operating Expenses. The term “Operating Expenses” as used in the Lease to which this
Exhibit B is attached means the sum of Building Operating Expenses and Common Area Operating Expenses. 
 “Building Operating
Expenses” shall mean, with respect to any period, and without duplication, all reasonable and customary costs of whatsoever type of character paid or incurred by Landlord during such period in connection with the operation, repair
and maintenance of the Premises and the Building as determined by generally accepted accounting practices, consistently applied, including, by way of illustration and not limitation, the following: (i) Landlord’s costs of fulfilling its
obligations pursuant to Section 8 of the Lease, including, but not limited to Landlord’s Services, to the extent Landlord is entitled to pass through said costs pursuant to said section; (ii) amortization on a straight line
basis over the useful life (together with interest at the Interest Rate on the unamortized balance) of all capitalized expenditures for the Building, other than in connection with the original construction, which are reasonably intended to produce a
reduction of Operating Expenses, (iii) Landlord’s insurance for the buildings in the Development, (iv) real property taxes imposed against the Building and other improvements on the legal parcels on which the buildings in the
Development are located, (v) all sewer, water, electricity, and other utility charges to the extent not paid directly by Tenant (including HVAC for the Building during normal business hours), and utilities surcharges and any other costs, levies
or assessments resulting from statutes or regulations promulgated by any government or quasi-government authority in connection with the use, occupancy or alteration of the Building or the Premises or the parking facilities serving the Building or
the Premises, (vi) labor costs incurred in the operation and repair of the portion of the Building that is Landlord’s obligation under the Lease, including without limitation, supplies, wages, and salaries (including payroll taxes and
similar governmental charges related thereto) of employees at the grade of building manager or below that are used in the management, operation and maintenance of the Building, (vii) supplies, equipment and related operating expenses, and a
management/administrative fee, (viii) reasonable accounting, audit, verification, legal and other consulting fees related directly to the operation of the Development, (ix) amortization on a straight line basis over the useful life
(together with interest at the Interest Rate on the unamortized balance) of all costs resulting from Landlord’s replacement during any Option Term, if applicable, of the roof, HVAC above the roof level, and/or the Building elevators; 

“Common Area Operating Expenses” shall mean, with respect to any period, without duplication, all reasonable and
customary costs and expenses paid or incurred by Landlord during such period, in connection with the operation, repair and maintenance of the Common Areas of the Development, excluding Common Areas within the Building (as such terms are defined in
the Lease); as determined by generally accepted accounting practices, consistently applied, including the following costs by way of illustration but not limitation: (a) water and sewer charges and the costs of electricity, and other utilities
serving the Common Areas; (b) costs of insurance for the Common Areas not paid by Tenant pursuant to the paragraph immediately above; (c) waste disposal and janitorial services related solely to the Common Areas; (d) security for the
Common Areas (if Landlord elects, in its sole and absolute discretion, to obtain security services or equipment); (e) labor costs incurred in the operation, repair, and management of the Development, including without limitation, supplies, wages and
salaries (including payroll taxes and similar governmental charges related thereto) of employees at the grade of building manager or below to the extent used in the management, operation and maintenance of the Development; (f) Development
management office rental (not to exceed the prevailing market rental rate), supplies, equipment and related operating expenses; (g) supplies, materials, equipment and tools including rental of personal property used for maintenance of the
Common Area; (h) repair and maintenance of the plumbing, irrigation, electrical, drainage and storm drain systems of the Common Area; (i) maintenance, costs and upkeep of all parking and other Common Areas; (j) depreciation on a
straight line basis and rental of personal property used in maintenance of the Common Areas; (k) amortization on a straight line basis over the useful life of all non-structural capitalized expenditures
related to the Common Areas, other than in connection with the initial construction, which are (i) reasonably intended to produce a reduction in Operating Expenses; or (ii) required under any governmental law or regulation that was not
applicable to the Development at the time it was originally constructed; or (iii) for replacement of any Development equipment 

  
 EXHIBIT B 

-1- 

 needed to operate the Development at the same quality levels as prior to the replacement; (l) costs and
expenses or gardening or landscaping; (m) maintenance of signs (other than Tenant’s signs, and signs of other tenants of the Development, or relating to marketing activities); (n) personal property taxes levied on or attributable to
personal property used in connection with the Common Areas; (o) reasonable accounting, audit, legal and other consulting fees; and (p) costs and expenses of repairs, resurfacing, repairing, maintenance, painting, lighting, cleaning, refuse
removal, security and similar items. 
 2. Items Excluded From Operating Expenses. Expenses shall not include: depreciation; principal
payments of mortgage and other non-operating debts of Landlord; the cost of repairs or other work to the extent Landlord is reimbursed by insurance or condemnation proceeds; costs in connection with leasing
space in the Building, including brokerage commissions; lease concessions, rental abatements and construction allowances granted to specific tenants; costs incurred in connection with the sale, financing or refinancing of the Building; fines,
interest and penalties incurred due to the late payment of Taxes or Expenses; organizational expenses associated with the creation and operation of the entity which constitutes Landlord; or any penalties or damages that Landlord pays to Tenant under
this Lease or to other tenants in the Building under their respective leases. 
 3. Occupancy. If at any time during a calendar year
the Development is not at least ninety-five percent (95%) occupied or Landlord is not supplying services to at least ninety-five percent (95%) of the total rentable square footage of the Development, Expenses shall, at Landlord’s option, be
determined as if the Development had been ninety-five percent (95%) occupied and Landlord had been supplying services to ninety-five percent (95%) of the rentable square footage of the Development. 

4. Taxes. “Taxes” shall mean: (a) all real property taxes and other assessments on the Building and/or the
Development, including, but not limited to, gross receipts taxes, assessments for special improvement districts and building improvement districts, governmental charges, fees and assessments for police, fire, traffic mitigation or other governmental
service of purported benefit to the Development, taxes and assessments levied in substitution or supplementation in whole or in part of any such taxes and assessments and the Development’s share of any real estate taxes and assessments under
any reciprocal easement agreement, common area agreement or similar agreement as to the Development; (b) all personal property taxes for property that is owned by Landlord and used in connection with the operation, maintenance and repair of the
Development; and (c) all costs and fees incurred in connection with seeking reductions in any tax liabilities described in (a) and (b), including, without limitation, any costs incurred by Landlord for compliance, review and appeal of tax
liabilities. Without limitation, Taxes shall not include any income, capital levy, capital stock, gift, estate or inheritance tax. 

  
 EXHIBIT B 

-2- 

 EXHIBIT C 

WORK LETTER 
 This Exhibit is
attached to and made a part of the Lease by and between BIXBY SPE FINANCE 11, LLC, a Delaware limited liability company (“Landlord”) and SI-BONE, INC., a Delaware corporation
(“Tenant”) for space in the Building located at 471 El Camino Real, Santa Clara, California. 
  

	1.	 This Work Letter shall set forth the obligations of Landlord and Tenant with respect to the improvements to be
performed in the Premises for Tenant’s use. All improvements described in this Work Letter to be constructed in and upon the Premises by Landlord are hereinafter referred to as the “Landlord Work”. With the
exception of the improvements described in Section 2 below and set forth in the Landlord-Funded Space Plan, attached hereto as Schedule 1, it is agreed that construction of the Landlord Work will be completed at Tenant’s sole
cost and expense, subject to the Amortized Allowance (as defined below). Landlord shall enter into a direct contract for the Landlord Work with a general contractor selected by Landlord. In addition, Landlord shall have the right to select and/or
approve of any subcontractors used in connection with the Landlord Work. 

  

	2.	 Landlord, at its sole cost and expense, shall perform improvements to the Premises in accordance with the space
plan attached hereto as Schedule 1 (the “Landlord-Funded Space Plan”) using Building standard methods, materials and finishes. 

  

	3.	 Other than the improvements described in Section 2 above and set forth in the Landlord-Funded Space
Plan, the Landlord Work will be completed at Tenant’s sole cost and expense, subject to the Amortized Allowance, and shall be completed in accordance with (i) the final architectural, electrical and mechanical construction drawings, plans
and specifications (called “Final Plans”), and (ii) the space plan approved by Landlord and Tenant and attached hereto as Schedule 2 (the “Tenant-Funded Space Plan”), which both
(i) and (ii) have been approved by Landlord and Landlord’s architect and engineers and shall comply with their requirements to avoid aesthetic or other conflicts with the design and function of the balance of the Building.

  

	4.	 A written estimate setting forth the anticipated cost to construct the work (the “Tenant-Funded
Work”) outlined in the Tenant-Funded Space Plan, including but not limited to labor and materials, contractor’s fees and permit fees is attached hereto as Schedule 2(a) (the “Estimate”). Concurrently with the
delivery of this Lease, Tenant shall deliver to Landlord the amount equal to $89,999.00. This amount shall be comprised of the total cost set forth in the Estimate plus a construction management fee payable to Landlord equivalent to three percent
(3%) of the total cost of construction, including any design fees, that exceeds the sum of the Allowance and the Amortized Allowance (as defined in Paragraph 6 hereof), such amount exceeding the sum of the Allowance and the Amortized
Allowance being herein referred to as the “Excess Costs”. Tenant acknowledges and agrees that when the actual amount of the Tenant-Funded Work becomes known, if Tenant has underpaid the Excess Costs, then upon notice
by Landlord to Tenant, Tenant shall reimburse Landlord for such shortfall within ten (10) days after Landlord delivers to Tenant said notice. Within thirty (30) days of Substantial Completion, Landlord will reconcile the Excess Costs paid
by Tenant hereunder with the actual costs reflected in the Estimate, and any overpayment by Tenant shall be reimbursed by Landlord within such 30-day period. The statements of costs submitted to Landlord by
Landlord’s contractors shall be conclusive for purposes of determining the actual cost of the items described therein. The amounts payable by Tenant hereunder constitute Rent payable pursuant to the Lease, and the failure to timely pay same
constitutes an event of Default under the Lease. 

  

	5.	 If Tenant shall request any change, addition or alteration in any of the Final Plans after approval by
Landlord, Landlord shall have such revisions to the drawings prepared, and Tenant shall reimburse Landlord for the cost thereof, plus any applicable state sales or use tax thereon, upon demand. Promptly upon completion of the revisions, Landlord
shall notify Tenant in writing of the increased cost which will be chargeable to Tenant by reason of such change, addition or deletion. Tenant, within one (1) business day, shall notify Landlord in writing whether it desires to proceed with
such change, addition or deletion, provided that such changes, additions or deletions shall constitute a Tenant Delay to the extent they impact the date of Substantial Completion. In the absence of such written authorization, Landlord shall have the
option to continue work on the Premises disregarding the requested change, addition or alteration, or 

  
 EXHIBIT C 

-1- 

	 	Landlord may elect to discontinue work on the Premises until it receives notice of Tenant’s decision, in which event Tenant shall be responsible for any Tenant Delay in completion of the Premises resulting
therefrom. If such revisions result in a higher estimate of the cost of construction and/or higher actual construction costs which exceed the Estimate, such increased estimate or costs shall be deemed Excess Costs pursuant to Paragraph 4
hereof and Tenant shall pay such Excess Costs, plus any applicable state sales or use tax thereon, upon demand. Notwithstanding the foregoing, Landlord and Tenant shall work together to coordinate the timing of completion of the Tenant-Funded Work.
Such coordination shall include reasonable ongoing consultation and communication regarding work scheduling. 

  

	6.	 Provided Tenant is not in default, Landlord agrees to provide Tenant with an allowance of $85,000 as
contribution toward the cost of completing the Tenant-Funded Work (the “Allowance”). In addition to the foregoing, Landlord agrees to provide Tenant with an allowance (the “Amortized Allowance”) in an amount not to
exceed $100,000.00 (i.e., approximately $4.58 per rentable square foot of the Premises) to be applied toward the cost of the Tenant-Funded Work. The amount of Amortized Allowance actually disbursed by Landlord shall be confirmed in writing as
the “Amortized Allowance Amount”. As a condition to the disbursement of the Amortized Allowance Amount, no later than thirty (30) days following the Substantial Completion of the Landlord Work, Tenant shall execute and deliver
an amendment to the Lease pursuant to which Tenant agrees to pay additional monthly Base Rent in an amount equal to the amount necessary to fully amortize the Amortized Allowance Amount over the entirety of the Term at an interest rate equal to
eight percent (8%) per annum (the “Amortized Allowance Rent”), provided, however, that such Amortized Allowance Rent shall not be subject to annual escalation along with the Base Rent set forth above. Tenant shall have the right to
pay off the unamortized principal balance of the Amortized Allowance Amount (together with all accrued but unpaid interest thereon) at any time during the Term without premium or penalty. Tenant shall not be entitled to receive any cash payment or
credit against monthly Base Rent or otherwise for any unused portion of the Amortized Allowance which is not used to pay for the Tenant-Funded Work. 

  

	7.	 For purposes of this Lease, including for purposes of determining the Commencement Date (pursuant to
Section 2 of the Lease), the Landlord Work shall be “Substantially Complete” upon the completion of the Landlord Work in the Premises pursuant to the Tenant-Funded Space Plan, with the exception of any punch list items
that do not materially and adversely affect Tenant’s use and occupancy of the Premises and any tenant fixtures, work-stations, built-in furniture, or equipment to be installed by or on behalf of Tenant in
accordance with the terms of this Work Letter, regardless of whether such items are reflected in the Final Plans. Tenant will be deemed to have accepted the Premises in its condition as of the Commencement Date, subject to all Laws (as defined in
Section 4 of the Lease) governing and regulating the use and occupancy of the Premises and to have acknowledged that there are no items needing work or repair by Landlord, with the exception of any punch list items as described above.
Notwithstanding the foregoing, if it is determined that the Premises were not in good condition and in compliance with applicable laws, rules and regulations as of the Commencement Date, and such
non-compliance is not due to Tenant’s particular use of, or activities or work in the Premises, Landlord shall (as Tenant’s sole remedy therefor) correct such
non-compliance at Landlord’s cost within a commercially reasonable time after Landlord’s receipt of written notice thereof (provided that such notice must be received within sixty (60) days
following the Commencement Date). 

  

	8.	 If there shall be a delay or there are delays in the Substantial Completion of the Premises as a direct,
indirect, partial, or total result of any of the following (each a “Tenant Delay”, and collectively, “Tenant Delays”): 

 

	 	a.	 Tenant’s failure to comply with its obligations under this Exhibit C or the Lease;

  

	 	b.	 Tenant’s request for changes to the Landlord Work; 

 

	 	c.	 Tenant’s specification of any materials or equipment with long lead times; or 

 

	 	c.	 any other acts or omissions of Tenant, the Tenant Related Parties or their respective contractors or vendors

  
 EXHIBIT C 

-2- 

 then, notwithstanding anything to the contrary set forth in the Lease and regardless of the
actual date of Substantial Completion, the Lease Commencement Date shall be deemed to be the date the Lease Commencement Date would have occurred if no Tenant Delays, as set forth above, had occurred. 

 

	9.	 This Exhibit shall not be deemed applicable to any additional space added to the Premises at any time or from
time to time, whether by any options under the Lease or otherwise, or to any portion of the original Premises or any additions to the Premises in the event of a renewal or extension of the original Term of the Lease, whether by any options under the
Lease or otherwise, unless expressly so provided in the Lease or any amendment or supplement to the Lease. 

  
 EXHIBIT C 

-3- 

 SCHEDULE 1 TO EXHIBIT C 

LANDLORD-FUNDED SPACE PLAN 
  

 

  
 SCHEDULE 1 TO EXHIBIT C

 -1- 

 SCHEDULE 2 TO EXHIBIT C 

TENANT-FUNDED SPACE PLAN 
  

 

  
 SCHEDULE 2 TO EXHIBIT C

 -1- 

 SCHEDULE 2(a) TO EXHIBIT C 

ESTIMATE 
  

					
	

	  	PRELIMINARY ESTIMATE	  	

  

			
	Date:	  	1/30/18
	Property:	  	University Station
	Building:	  	471 El Camino Real
	Suite:	  	100
	Tenant:	  	8I-BONE, Inc.
	RSF:	  	21,848

  

															
	 	 	 	  	 	 	 	COST	 	  	$RSF	 
	 Construction Costs:
	 	Gidel & Kocal Construction	  				 	$	247,280	 	  	$	11.32	 
	 Architecture: IA Interior Architects
	 	Space Plan	  				 	$	1,000	 	  	$	0.05	 
		 	Pricing Plan	  				 	$	—  	 	  	$	—  	 
		 	Schematic Design	  				 	$	—  	 	  	$	—  	 
		 	Design Development	  				 	$	—  	 	  	$	—  	 
		 	Field Verification	  				 	$	—  	 	  	$	—  	 
		 	Construction Documents	  				 	$	9,000	 	  	$	0.41	 
		 	Plancheck Submittal	  				 	$	—  	 	  	$	—  	 
		 	City Revisions	  				 	$	—  	 	  	$	—  	 
		 	Construction Administration	  				 	$	5,000	 	  	$	0.23	 
		 	Reimbursables (allowance)	  				 	$	1,000	 	  	$	0.05	 
	 Engineering:
	 	MEP Construction Documents W’ Title 24 (Design Build)	  				 	$	—  	 	  	$	—  	 
		 	Title 24 Commissioning (allowance)	  				 	$	—  	 	  	$	—  	 
		 	Fire Sprinkler Design Build	  				 	 	Incl	 	  	$	—  	 
		 	Fire Life Safety Design Build	  				 	 	Incl	 	  	$	—  	 
	 Permits
	 	On Construction Cost Above (allowance)	  	 	1.50	% 	 	$	3,709	 	  	$	0.17	 
	 Contingency
	 	On All Costs Above	  	 	0	% 	 	$	—  	 	  	$	—  	 
	 Bixby CM Fee
	 	On All Costs Above	  	 	3	% 	 	 	8,010	 	  	$	0.37	 
	 TOTAL PROJECT COST (NOT INCL. ALTERNATES BELOW)
	 		  				 	$	274,999	 	  	$	12.59	 
	 Alternates:
	 		  				 				  			
	 1
	 		  				 	$	—  	 	  	$	—  	 
	 2
	 		  				 	$	—  	 	  	$	—  	 
	 SUBTOTAL:
	 		  				 	$	—  	 	  	$	—  	 
	 TOTAL PROJECT COST (INCLUDING ALTERNATES)
	 		  				 	$	274,999	 	  	$	12.68	 
		

 Scope: 

 
 Qualifications: 

 

  
 SCHEDULE 2(a) TO EXHIBIT
C 
 -1- 

 EXHIBIT D 

BUILDING RULES AND REGULATIONS 

This Exhibit is attached to and made a part of the Lease by and between BIXBY SPE FINANCE 11, LLC, a Delaware limited liability company
(“Landlord”) and SI-BONE, INC., a Delaware corporation (“Tenant”) for space in the Building located at 471 El Camino Real, Santa Clara, California. 

The following rules and regulations shall apply, where applicable, to the Premises, the Building, the parking garage (if any), the Development
and the appurtenances. In the event of a conflict between the following rules and regulations and the remainder of the terms of the Lease, the remainder of the terms of the Lease shall control. Capitalized terms have the same meaning as defined in
the Lease. 
  

	1.	 Sidewalks, doorways, vestibules, halls, stairways and other similar areas shall not be obstructed by Tenant or
used by Tenant for any purpose other than ingress and egress to and from the Premises. No rubbish, litter, trash, or material shall be placed, emptied, or thrown in those areas. At no time shall Tenant permit Tenant’s employees to loiter in
Common Areas or elsewhere about the Building or Development. 

  

	2.	 Plumbing fixtures and appliances shall be used only for the purposes for which designed, and no sweepings,
rubbish, rags or other unsuitable material shall be thrown or placed in the fixtures or appliances. Damage resulting to fixtures or appliances by Tenant, its agents, employees or invitees, shall be paid for by Tenant, and Landlord shall not be
responsible for the damage. 

  

	3.	 No signs, advertisements or notices shall be painted or affixed to windows, doors or other parts of the
Building, except those of such color, size, style and in such places as are first approved in writing by Landlord. All tenant identification and suite numbers at the entrance to the Premises shall be installed by Landlord, at Tenant’s cost and
expense, using the standard graphics for the Building. Except in connection with the hanging of lightweight pictures and wall decorations, no nails, hooks or screws shall be inserted into any part of the Premises or Building except by the Building
maintenance personnel without Landlord’s prior approval, which approval shall not be unreasonably withheld. 

  

	4.	 Landlord may provide and maintain in the first floor (main lobby) of the Building an alphabetical directory
board or other directory device listing tenants, and no other directory shall be permitted unless previously consented to by Landlord in writing. 

  

	5.	 Tenant shall not place any lock(s) on any door in the Premises or Building without Landlord’s prior
written consent, which consent shall not be unreasonably withheld, and Landlord shall have the right to retain at all times and to use keys or other access codes or devices to all locks within and into the Premises. A reasonable number of keys to
the locks on the entry doors in the Premises shall be furnished by Landlord to Tenant at Tenant’s cost, and Tenant shall not make any duplicate keys. All keys shall be returned to Landlord at the expiration or early termination of this Lease.

  

	6.	 All contractors, contractor’s representatives and installation technicians performing work in the Building
shall be subject to Landlord’s prior approval, which approval shall not be unreasonably withheld, and shall be required to comply with Landlord’s standard rules, regulations, policies and procedures, which may be revised from time to time.

  

	7.	 Movement in or out of the Building of furniture or office equipment, or dispatch or receipt by Tenant of
merchandise or materials requiring the use of elevators, stairways, lobby areas or loading dock areas, shall be restricted to hours reasonably designated by Landlord. Tenant shall obtain Landlord’s prior approval by providing a detailed listing
of the activity. If approved by Landlord, the activity shall be under the supervision of Landlord and performed in the manner required by Landlord. Tenant shall assume all risk for damage to articles moved and injury to any persons resulting from
the activity. If equipment, property, or personnel of Landlord or of any other party is damaged or injured as a result of or in connection with the activity, Tenant shall be solely liable for any resulting damage or loss. 

  
 EXHIBIT D 

-1- 

	8.	 Landlord shall have the right to approve the weight, size, or location of heavy equipment or articles in and
about the Premises, which approval shall not be unreasonably withheld. Damage to the Building by the installation, maintenance, operation, existence or removal of Tenant’s Property shall be repaired at Tenant’s sole expense.

  

	9.	 Corridor doors, when not in use, shall be kept closed. 

 

	10.	 Tenant shall not: (i) make or permit any improper, objectionable or unpleasant noises or odors in the
Building, or otherwise interfere in any way with other tenants or persons having business with them; (ii) solicit business or distribute, or cause to be distributed, in any portion of the Building, handbills, promotional materials or other
advertising; or (iii) conduct or permit other activities in the Building that might, in Landlord’s sole opinion, constitute a nuisance. 

  

	11.	 No animals, except those assisting handicapped persons, shall be brought into the Building or kept in or about
the Premises. 

  

	12.	 No inflammable, explosive or dangerous fluids or substances shall be used or kept by Tenant in the Premises,
Building or about the Development, except for those substances as are typically found in similar premises used for general office and research and development purposes and are being used by Tenant in a safe manner and in accordance with all
applicable Laws, rules and regulations. Tenant shall not, without Landlord’s prior written consent, use, store, install, spill, remove, release or dispose of, within or about the Premises or any other portion of the Development, any
asbestos-containing materials or any solid, liquid or gaseous material now or subsequently considered toxic or hazardous under the provisions of 42 U.S.C. Section 9601 et seq. or any other applicable environmental Laws which may now or later be
in effect. Tenant shall comply with all Laws pertaining to and governing the use of these materials by Tenant, and shall remain solely liable for the costs of abatement and removal. 

 

	13.	 Tenant shall not use or occupy the Premises in any manner or for any purpose which might injure the reputation
or impair the present or future value of the Premises or the Building. Tenant shall not use, or permit any part of the Premises to be used, for lodging, sleeping or for any illegal purpose. 

 

	14.	 Tenant shall not take any action which would violate Landlord’s labor contracts or which would cause a
work stoppage, picketing, labor disruption or dispute, or interfere with Landlord’s or any other tenant’s or occupant’s business or with the rights and privileges of any person lawfully in the Building (“Labor
Disruption”). Tenant shall take the actions necessary to resolve the Labor Disruption, and shall have pickets removed and, at the request of Landlord, immediately terminate any work in the Premises that gave rise to the Labor Disruption,
until Landlord gives its written consent for the work to resume. Tenant shall have no claim for damages against Landlord or any of the Landlord Related Parties, nor shall the Commencement Date of the Term be extended as a result of the above
actions. 

  

	15.	 Tenant shall not install, operate or maintain in the Premises or in any other area of the Building, electrical
equipment that would overload the electrical system beyond its capacity for proper, efficient and safe operation as determined solely by Landlord. Tenant shall not furnish cooling or heating to the Premises, including, without limitation, the use of
electronic or gas heating devices, without Landlord’s prior written consent. Tenant shall not use more than its proportionate share of telephone lines and other telecommunication facilities available to service the Building.

  

	16.	 Tenant shall not operate or permit to be operated a coin or token operated vending machine or similar device
(including, without limitation, telephones, lockers, toilets, scales, amusement devices and machines for sale of beverages, foods, candy, cigarettes and other goods), except for machines for the exclusive use of Tenant’s employees and invitees.

  

	17.	 Bicycles and other vehicles are not permitted inside the Building or on the walkways outside the Building,
except in areas designated by Landlord. 

  

	18.	 Landlord may from time to time adopt systems and procedures for the security and safety of the Building, its
occupants, entry, use and contents. Tenant, its agents, employees, contractors, guests and invitees shall comply with Landlord’s systems and procedures. 

  
 EXHIBIT D 

-2- 

	19.	 Landlord shall have the right to prohibit the use of the name of the Building or any other publicity by Tenant
that in Landlord’s sole opinion may impair the reputation of the Building or its desirability. Upon written notice from Landlord, Tenant shall refrain from and discontinue such publicity immediately. 

 

	20.	 Neither Tenant nor its agents, employees, contractors, guests or invitees shall smoke or permit smoking in the
Common Areas, unless the Common Areas have been declared a designated smoking area by Landlord, nor shall the above parties allow smoke from the Premises to emanate into the Common Areas or any other part of the Building. Landlord shall have the
right to designate the Building (including the Premises) as a non-smoking building. 

  

	21.	 Landlord shall have the right to designate and approve standard window coverings for the Premises and to
establish rules to assure that the Building presents a uniform exterior appearance. Tenant shall ensure, to the extent reasonably practicable, that window coverings are closed on windows in the Premises while they are exposed to the direct rays of
the sun. 

  

	22.	 Deliveries to and from the Premises shall be made only at the times, in the areas and through the entrances and
exits reasonably designated by Landlord. Tenant shall not make deliveries to or from the Premises in a manner that might interfere with the use by any other tenant of its premises or of the Common Areas, any pedestrian use, or any use which is
inconsistent with good business practice. 

  

	23.	 The work of cleaning personnel shall not be hindered by Tenant after 5:30 P.M., and cleaning work may be done
at any time when the offices are vacant. Windows, doors and fixtures may be cleaned at any time. Tenant shall provide adequate waste and rubbish receptacles to prevent unreasonable hardship to the cleaning service. 

PARKING RULES AND REGULATIONS 
  

	(i)	 Landlord reserves the right, to establish and reasonably change the hours for the parking areas, on a non-discriminatory basis, from time to time. Tenant shall not store or permit its employees to store any automobiles in the parking areas without the prior written consent of the operator. Except for emergency
repairs, Tenant and its employees shall not perform any work on any automobiles while located in the parking areas, or on the Development. If it is necessary for Tenant or its employees to leave an automobile in the Parking Facility overnight,
Tenant shall provide the operator with prior notice thereof designating the license plate number and model of such automobile. 

  

	(ii)	 Cars must be parked entirely within the stall lines painted on the floor, and only small cars may be parked in
areas reserved for small cars. 

  

	(iii)	 All directional signs and arrows must be observed. 

 

	(iv)	 The speed limit shall be 5 miles per hour. 

 

	(v)	 Parking spaces reserved for handicapped persons must be used only by vehicles properly designated.

  

	(vi)	 Parking is prohibited in all areas not expressly designated for parking, including without limitation:

  

	 	(a)	 areas not striped for parking 

 

	 	(b)	 aisles 

  

	 	(c)	 where “no parking” signs are posted 

 

	 	(d)	 ramps 

  

	 	(e)	 loading zones 

  

	(vii)	 Parking stickers, key cards or any other devices or forms of identification or entry supplied by the operator
shall remain the property of the operator. Such device must be displayed as requested and may not be mutilated in any manner. The serial number of the parking identification device may not be obliterated. Parking passes and devices are not
transferable and any pass or device in the possession of an unauthorized holder will be void. 

  

	(viii)	 Parking areas managers or attendants are not authorized to make or allow any exceptions to these Rules.

  
 EXHIBIT D 

-3- 

	(ix)	 Every parker is required to park and lock his/her own car. 

 

	(x)	 Loss or theft of parking pass, identification, key cards or other such devices must be reported to Landlord and
to the parking areas manager immediately. Any parking devices reported lost or stolen found on any authorized car will be confiscated and the illegal holder will be subject to prosecution. Lost or stolen passes and devices found by Tenant or its
employees must be reported to the office of the parking areas immediately. 

  

	(xi)	 Washing, waxing, cleaning or servicing of any vehicle by the customer and/or his agents is prohibited. Parking
spaces may be used only for parking automobiles. 

  

	(xii)	 Tenant agrees to acquaint all persons to whom Tenant assigns a parking space with these Rules.

  

	1.	 TENANT ACKNOWLEDGES AND AGREES THAT, TO THE FULLEST EXTENT PERMITTED BY LAW, LANDLORD SHALL NOT BE RESPONSIBLE
FOR ANY LOSS OR DAMAGE TO TENANT OR TENANT’S PROPERTY (INCLUDING, WITHOUT LIMITATIONS, ANY LOSS OR DAMAGE TO TENANT’S AUTOMOBILE OR THE CONTENTS THEREOF DUE TO THEFT, VANDALISM OR ACCIDENT) ARISING FROM OR RELATED TO TENANT’S USE OF
THE PARKING AREAS OR EXERCISE OF ANY RIGHTS UNDER THIS PARKING AGREEMENT, WHETHER OR NOT SUCH LOSS OR DAMAGE RESULTS FROM LANDLORD’S ACTIVE NEGLIGENCE OR NEGLIGENT OMISSION. THE LIMITATION ON LANDLORD’S LIABILITY UNDER THE PRECEDING
SENTENCE SHALL NOT APPLY HOWEVER TO LOSS OR DAMAGE ARISING DIRECTLY FROM LANDLORD’S WILLFUL MISCONDUCT. 

  

	2.	 Without limiting the provisions of Paragraph 1 above, Tenant hereby voluntarily releases, discharges,
waives and relinquishes any and all actions or causes of action for personal injury or property damage occurring to Tenant arising as a result of parking in the parking areas or any activities incidental thereto, wherever or however the same may
occur, and further agrees that Tenant will not prosecute any claim for personal injury or property damage against Landlord or any of its officers, agents, servants or employees for any said causes of action. It is the intention of Tenant by this
instrument, to exempt and relieve Landlord from liability for personal injury or property damage caused by negligence. 

  

	3.	 The provisions of Section 29 of the Lease are hereby incorporated by reference as if fully recited.

 By executing the Lease to which this Exhibit D is attached, Tenant acknowledges that it has read and agreed to be
bound by the forgoing Building Rules and Regulations. Tenant further confirms that it has been fully and completely advised of the potential dangers incidental to parking in the parking areas and the terms and conditions set forth above. 

  
 EXHIBIT D 

-4- 

 EXHIBIT E 

STATEMENT OF TENANT REGARDING LEASE COMMENCEMENT 

This Exhibit is attached to and made a part of the Lease by and between BIXBY SPE FINANCE 11, LLC, a Delaware limited liability company
(“Landlord”) and SI-BONE, INC., a Delaware corporation (“Tenant”) for space in the Building located at 471 El Camino Real, Santa Clara, California. 

 

	1)	 The undersigned has entered into occupancy of the Premises described in said Lease on
                    , 20        . 

 

	2)	 All conditions under said Lease to be performed by Landlord have been satisfied, and on this date there are not
existing defenses or offsets which the undersigned has against the enforcement of said Lease by Landlord; 

  

	3)	 The Term of the Lease commenced, or will commence, as of
                    , 20        , which date shall be the “Commencement Date”
under the terms of the Lease; 

  

	4)	 The “Expiration Date” of the Lease is
                    , 20        , subject to extension or earlier termination in accordance with the terms
and conditions of the Lease. 

  

	5)	 Tenant accepts the Premises in its “AS-IS” condition
as of the date of Tenant’s possession thereof. 

  

			
	Yours very truly,
	
	 SI-BONE, INC.,

a Delaware corporation

 
			
		
	By:	 	  

	Name:	 	  

	Its:	 	  

  
 EXHIBIT E 

-1- 

 EXHIBIT F 

RECORDED RESTRICTIONS 

This Exhibit is attached to and made a part of the Lease by and between BIXBY SPE FINANCE 11, LLC, a Delaware limited liability company
(“Landlord”) and SI-BONE, INC., a Delaware corporation (“Tenant”) for space in the Building located at 471 El Camino Real, Santa Clara, California. 

Declaration of Covenants, Conditions and Restrictions and Reservation of Easements dated September 10, 1998 and recorded in the Official Records of Santa
Clara County on September 15, 1998 as Document No. 14390154. 

  
 EXHIBIT F 

-1- 

 RIDER NO. 1 

EXTENSION OPTION RIDER 

This Rider No. 1 is made and entered into by and between BIXBY SPE FINANCE 11, LLC, a Delaware limited liability company
(“Landlord”) and SI-BONE, INC., a Delaware corporation (“Tenant”), as of the day and year of the Lease between Landlord and Tenant to which this Rider is attached.
Landlord and Tenant hereby agree that, notwithstanding anything contained in the Lease to the contrary, the provisions set forth below shall be deemed to be part of the Lease and shall supersede any inconsistent provisions of the Lease. All
references in the Lease and in this Rider to the “Lease” shall be construed to mean the Lease (and all Exhibits and Riders attached thereto), as amended and supplemented by this Rider. All capitalized terms not defined in this Rider shall
have the same meaning as set forth in the Lease. 
 1. Landlord hereby grants to Tenant (1) option (the “Extension
Option”) to extend the Term of the Lease for an additional period of five (5) years (the “Option Term”), on the same terms, covenants and conditions as provided for in the Lease during the initial
Term, except for the monthly Base Rent, which shall equal the “fair market rental rate” for the Premises for the Option Term as defined and determined in accordance with the provisions of Section 3 below. 

2. The Extension Option must be exercised, if at all, by written notice (“Extension Notice”) delivered by Tenant
to Landlord no sooner than that date which is twelve (12) months and no later than that date which is nine (9) months prior to the expiration of the then current Term of the Lease. The Extension Option shall, at Landlord’s sole
option, not be deemed to be properly exercised if, at the time the Extension Option is exercised or on the scheduled commencement date for the Option Term, Tenant has (a) committed an uncured event of Default whose cure period has expired
pursuant to Sections 19 and 20 of the Lease, (b) assigned all or any portion of the Lease or its interest therein, or (c) sublet all or any portion of the Premises. Provided Tenant has properly and timely exercised the
Extension Option, the then current term of the Lease shall be extended by the Option Term, and all terms, covenants and conditions of the Lease shall remain unmodified and in full force and effect, except that the monthly Base Rent shall be as set
forth above. 
 3. If the Monthly Base Rent for the Option Term shall be the fair market rental rate pursuant to Section 1 above,
then such fair market rate shall be determined in accordance with the Fair Market Rental Rate Rider attached to the Lease as Rider No. 2. 

[REMAINDER OF PAGE INTENTIONALLY BLANK] 

  
 RIDER NO. 1 

-1- 

 RIDER NO. 2 

FAIR MARKET RENTAL RATE 

This Rider No. 2 is made and entered into by and BIXBY SPE FINANCE 11, LLC, a Delaware limited liability company
(“Landlord”) and SI-BONE, INC., a Delaware corporation (“Tenant”), as of the day and year of the Lease between Landlord and Tenant to which this Rider is
attached. Landlord and Tenant hereby agree that, notwithstanding anything contained in the Lease to the contrary, the provisions set forth below shall be deemed to be part of the Lease and shall supersede any inconsistent provisions of the Lease.
All references in the Lease and in this Rider to the “Lease” shall be construed to mean the Lease (and all Exhibits and Riders attached thereto), as amended and supplemented by this Rider. All capitalized terms not defined in this Rider
shall have the same meaning as set forth in the Lease. 
 1. The term “fair market rental rate” as used in the
Lease and any Rider attached thereto shall mean the annual amount per square foot, projected during the Option Term that a willing, non-equity renewal tenant (excluding sublease and assignment transactions)
would pay, and a willing, institutional landlord of a comparable Class “A” office building located in the Santa Clara, California market area (the “Comparison Area”) would accept, in an arm’s length transaction
(what Landlord is accepting in then current transactions for the buildings located in the Project may be used for purposes of projecting rent for the Option Term), for space of comparable size, quality and floor height as the Premises, taking into
account the age, quality and layout of the existing improvements in the Premises, and taking into account items that professional real estate brokers or professional real estate appraisers customarily consider, including, but not limited to, rental
rates, space availability, tenant size, tenant improvement allowances, parking charges and any other lease considerations, if any, then being charged or granted by Landlord or the lessors of such similar office buildings. All economic terms other
than Monthly Base Rent, such as tenant improvement allowance amounts, if any, operating expense allowances, parking charges, etc., will be established by Landlord and will be factored into the determination of the fair market rental rate for the
Option Term. Accordingly, the fair market rental rate will be an effective rate, not specifically including, but accounting for, the appropriate economic considerations described above. The fair market rental rate shall include the periodic rental
increases that would be included for space leased for the period of the Option Term. 
 2. In the event the determination of fair market
rental rate is required under the Lease (as set forth in Rider No. 1 above), Landlord shall provide written notice of Landlord’s determination of the fair market rental rate not later than ninety (90) days following
Landlord’s receipt of Tenant’s Extension Notice. Tenant shall have ten (10) days (“Tenant’s Review Period”) after receipt of Landlord’s notice of the fair market rental rate within which to accept
such fair market rental rate or to reasonably object thereto in writing. Failure of Tenant to so object to the fair market rental rate submitted by Landlord in writing within Tenant’s Review Period shall conclusively be deemed Tenant’s
approval and acceptance thereof. If within Tenant’s Review Period Tenant objects to or is deemed to have disapproved the fair market rental rate submitted by Landlord, Landlord and Tenant will meet together with their respective legal counsel
to present and discuss their individual determinations of the fair market rental rate for the Premises under the parameters set forth in Section 1 above and shall diligently and in good faith attempt to negotiate a rental rate on the
basis of such individual determinations. Such meeting shall occur no later than ten (10) days after the expiration of Tenant’s Review Period. The parties shall each provide the other with such supporting information and documentation as
they deem appropriate. At such meeting if Landlord and Tenant are unable to agree upon the fair market rental rate, they shall each submit to the other their respective best and final offer as to the fair market rental rate. If Landlord and Tenant
fail to reach agreement on such fair market rental rate within five (5) business days following such a meeting (the “Outside Agreement Date”), Tenant’s Extension Option will be deemed null and void unless Tenant
demands appraisal, in which event each party’s determination shall be submitted to appraisal in accordance with the provisions of Section 3 below. 

3. (a) Landlord and Tenant shall each appoint one (1) competent, independent and impartial commercial real estate broker with at least ten
(10) years full time commercial real estate brokerage experience in the Comparison Area (each a “broker”). The determination of the brokers shall be limited solely to the issue of whether Landlord’s or Tenant’s last
proposed (as of the Outside Agreement Date) best and final fair market rental rate for the Premises is the closest to the actual fair market rental rate for the Premises as determined by the brokers, taking into account the requirements specified in
Section 1 above. Each such broker shall be appointed within fifteen (15) days after the Outside Agreement Date. 

  
 RIDER NO. 2 

-1- 

 (b) The two (2) brokers so appointed shall within fifteen (15) days of the date of
the appointment of the last appointed broker agree upon and appoint a third broker who shall be qualified under the same criteria set forth hereinabove for qualification of the initial two (2) brokers. 

(c) The three (3) brokers shall within thirty (30) days of the appointment of the third broker reach a decision as to whether the
parties shall use Landlord’s or Tenant’s submitted best and final fair market rental rate, and shall notify Landlord and Tenant thereof. During such thirty (30) day period, Landlord and Tenant may submit to the brokers such
information and documentation to support their respective positions as they shall deem reasonably relevant and Landlord and Tenant may each appear before the brokers jointly to question and respond to questions from the brokers. 

(d) The decision of the majority of the three (3) brokers shall be binding upon Landlord and Tenant and neither party shall have the right
to reject the decision or to nullify the exercise of the Extension Option. If either Landlord or Tenant fails to appoint a broker within the time period specified in Section 3(a) hereinabove, the broker appointed by one of them shall
within thirty (30) days following the date on which the party failing to appoint a broker could have last appointed such broker reach a decision based upon the same procedures as set forth above (i.e., by selecting either Landlord’s
or Tenant’s submitted best and final fair market rental rate), and shall notify Landlord and Tenant thereof, and such broker’s decision shall be binding upon Landlord and Tenant and neither party shall have the right to reject the decision
or to nullify the exercise of the Extension Option. 
 (e) If the two (2) brokers fail to agree upon and timely appoint a third broker,
either party, upon ten (10) days written notice to the other party, can apply to the Presiding Judge of the Superior Court of Orange County to appoint a third broker meeting the qualifications set forth herein. The third broker, however,
selected, shall be a person who has not previously acted in any capacity for either party. 
 (f) The cost of each party’s broker shall
be the responsibility of the party selecting such broker, and the cost of the third broker (or arbitration, if necessary) shall be shared equally by Landlord and Tenant. 

(g) If the process described hereinabove has not resulted in a selection of either Landlord’s or Tenant’s submitted best and final
fair market rental rate by the commencement of the applicable lease term, then the fair market rental rate estimated by Landlord will be used until the broker(s) reach a decision, with an appropriate rental credit and other adjustments for any
overpayments of Monthly Base Rent or other amounts if the brokers select Tenant’s submitted best and final estimate of the fair market rental rate. The parties shall enter into an amendment to this Lease confirming the terms of the decision.

 [REMAINDER OF PAGE INTENTIONALLY BLANK] 

  
 RIDER NO. 2 

-2- 

 RIDER NO. 3 

OPTIONS IN GENERAL 

This Rider No. 3 is made and entered into by and between BIXBY SPE FINANCE 11, LLC, a Delaware limited liability company
(“Landlord”) and SI-BONE, INC., a Delaware corporation (“Tenant”), as of the day and year of the Lease between Landlord and Tenant to which this Rider is attached.
Landlord and Tenant hereby agree that, notwithstanding anything contained in the Lease to the contrary, the provisions set forth below shall be deemed to be part of the Lease and shall supersede any inconsistent provisions of the Lease. All
references in the Lease and in this Rider to the “Lease” shall be construed to mean the Lease (and all Exhibits and Riders attached thereto), as amended and supplemented by this Rider. All capitalized terms not defined in this Rider shall
have the same meaning as set forth in the Lease. 
 (a) Definition. As used in this Lease and any Rider or Exhibit attached
hereto, the word “Option” shall mean all options granted to Tenant under the Lease, including the following: 
  

	 	•	 	 Extension Option pursuant to Rider No. 1 attached hereto. 

(b) Option Personal. The Option granted to Tenant is personal to the original Tenant executing the Lease (the
“Original Tenant”) and may be exercised only by the Original Tenant while occupying the entire Premises and without the intent of thereafter assigning the Lease or subletting the Premises and may not be exercised or be
assigned, voluntarily or involuntarily, by any person or entity other than the Original Tenant. The Option granted to Tenant under the Lease is not assignable separate and apart from the Lease, nor may the Option be separated from the Lease in any
manner, either by reservation or otherwise. 
 (c) Effect of Default on Options. Tenant will have no right to exercise any
Option, notwithstanding any provision of the grant of option to the contrary, and Tenant’s exercise of any Option may be nullified by Landlord and deemed of no further force or effect, if (i) Tenant is in default of any monetary obligation
or material non-monetary obligation under the terms of the Lease (or if Tenant would be in such default under the Lease but for the passage of time or the giving of notice, or both) as of Tenant’s
exercise of the Option in question or at any time after the exercise of any such Option and prior to the commencement of the Option event, or (ii) Landlord has given Tenant two (2) or more notices of default, whether or not such defaults
are subsequently cured, during any twelve (12) consecutive month period of the Lease. 
 (d) Option as Economic Term. The
Option is hereby deemed an economic term which Landlord, in its sole and absolute discretion, may or may not offer in conjunction with any future extensions of the Term. 

[REMAINDER OF PAGE INTENTIONALLY BLANK] 

  
 RIDER NO. 3 

-1- 

 UNIVERSITY STATION 

FIRST AMENDMENT TO LEASE 

(SI-BONE, INC.) 

THIS FIRST AMENDMENT TO LEASE (this “Amendment”) is made as of April 16, 2018, by and between BIXBY SPE
FINANCE 11, LLC, a Delaware limited liability company (“Landlord”) and SI-BONE, INC., a Delaware corporation (“Tenant”). 

RECITALS 
 A.
Landlord and Tenant are parties to that certain Office Lease Agreement dated as of February 2, 2018 (the “Lease”), with respect to certain premises within that certain building located at 471 El Camino Real, Santa Clara,
California (the “Building”). All capitalized terms used herein and not otherwise defined herein shall have the meanings set forth in the Lease. 

B. Pursuant to the Lease, Tenant leases from Landlord certain Premises located on the first (1st) floor of the Building, consisting of
approximately 21,848 square feet, as more particularly described in the Lease. 
 C. Landlord and Tenant desire to amend the Lease
confirm the suite number of the Premises. 
 AGREEMENT 

NOW, THEREFORE, in consideration of the mutual covenants contained herein, Landlord and Tenant agree that the Lease is hereby amended
as follows: 
 1. LEASE MODIFICATION. Under the Lease, the Premises was
incorrectly identified as Suite 100, although Tenant actually leases the suite commonly known as Suite 101. Accordingly, Landlord and Tenant hereby confirm that the Premises consist of Suite 101. The Lease, except as amended hereby, remains
unamended, and, as amended hereby, remains in full force and effect. 
 2. COMMENCEMENT
DATE. The Term of the Lease commenced, or will commence, as of April 1, 2018, which date shall be the “Commencement Date” under the terms of the Lease. 

3. AMORTIZED ALLOWANCE RENT; UPDATED RENT
SCHEDULE. It is acknowledged that Landlord has provided Tenant with an Amortized Allowance in the amount of $100,000.00 (the “Amortized Allowance Amount”) to be applied to the cost
of the Tenant-Funded Work pursuant to Section 6 of Exhibit C attached to the Lease. The monthly amortization schedule detailing the calculation of the Amortized Allowance Rent included in the monthly Base Rent is attached hereto
as Exhibit A. The rent schedule set forth in Section 1.03 of the Lease is hereby amended and restated as follows: 
  

					
	 Months of Term
	  	Monthly Base Rent	 
	 April 1, 2018 – December 31, 2018*
	  	$	49,031.57	 
	 January 1, 2019 – March 31, 2019
	  	$	56,151.57	 
	 April 1, 2019 – March 31, 2020
	  	$	57,790.17	 

  
 -1- 

					
	 Months of Term
	  	Monthly Base Rent	 
	 April 1, 2020 – March 31, 2021
	  	$	59,477.93	 
	 April 1, 2021 – March 31, 2022
	  	$	61,216.32	 
	 April 1, 2022 – March 31, 2023
	  	$	63,006.86	 
	 April 1, 2023 – March 31, 2024
	  	$	64,851.12	 
	 April 1, 2024 – March 31, 2025
	  	$	66,750.71	 
	 April 1, 2025 – May 31, 2025
	  	$	68,707.28	 

  

	*	 Subject to Abatement Period, as defined in Section 3.02 of the Lease. 

Notwithstanding anything to the contrary contained in Sections 3.02 and 3.03 of the Lease, Tenant shall be obligated to pay to Landlord the
monthly payments of the Amortized Allowance Rent (equal to $1,531.57 per month) during the Abatement Period and the Phase-in Period. 

4. BROKERS. Tenant represents and warrants to Landlord that it has not engaged any broker, finder
or other person who would be entitled to any commission or fees in respect of the negotiation, execution or delivery of this Amendment, and shall indemnify, defend and hold harmless Landlord against any loss, cost, liability or expense incurred by
Landlord as a result of any claim asserted by any broker, finder or other person on the basis of any arrangements or agreements made or alleged to have been made by or on behalf of Tenant. The provisions of this section shall not apply to brokers
with whom Landlord has an express written broker agreement. 
 5. CONTINUING
EFFECTIVENESS. The Lease, except as amended hereby, remains unamended, and, as amended hereby, remains in full force and effect. Tenant hereby confirms that no default by Tenant exists under the Lease. 

 6. COUNTERPARTS; ELECTRONIC DELIVERY. This Amendment may be
executed in one or more counterparts, each of which shall constitute an original and all of which shall be one and the same agreement. The parties may exchange counterpart signatures by facsimile or electronic transmission and the same shall
constitute delivery of this Amendment with respect to the delivering party.  
 7. EXECUTION BY
BOTH PARTIES. Submission of this instrument for examination or signature by Tenant does not constitute a reservation of or an option for lease, and it is not effective as a lease or otherwise
until execution and delivery by both Landlord and Tenant has occurred, and Landlord’s lender holding a lien with respect to the Building has approved this Amendment and the terms and conditions hereof.  

8. AUTHORIZATION. Tenant hereby confirms that the individual signing this Amendment on behalf of
Tenant is duly authorized to bind Tenant to the terms hereof. 
 9. REQUIRED ACCESSIBILITY
DISCLOSURE. Landlord hereby advises Tenant that the Development has not undergone an inspection by a certified access specialist, and except to the extent expressly set forth in the Lease, Landlord shall have no
liability or responsibility to make any repairs or modifications to the Premises or the Development in order to comply with accessibility standards. The following disclosure is hereby made pursuant to applicable California law:  

  
 -2- 

 “A Certified Access Specialist (CASp) can inspect the subject premises and determine
whether the subject premises comply with all of the applicable construction-related accessibility standards under state law. Although state law does not require a CASp inspection of the subject premises, the commercial property owner or lessor may
not prohibit the lessee or tenant from obtaining a CASp inspection of the subject premises for the occupancy or potential occupancy of the lessee or tenant, if requested by the lessee or tenant. The parties shall mutually agree on the arrangements
for the time and manner of the CASp inspection, the payment of the fee for the CASp inspection, and the cost of making any repairs necessary to correct violations of construction-related accessibility standards within the premises.” [Cal. Civ.
Code Section 1938(e)]. 
 Any CASp inspection shall be conducted in compliance with reasonable rules in effect at the Building with regard to such
inspections and shall be subject to Landlord’s prior written consent. 
 [LANDLORD’S SIGNATURE ON PAGE S-1 AND TENANT’S SIGNATURE ON PAGE S-2] 

  
 -3- 

 IN WITNESS WHEREOF, Landlord has executed this Amendment as of the day and year first
above written. 
  

									
	LANDLORD:	  		  	
		
	 BIXBY SPE FINANCE 11, LLC,
 a
Delaware limited liability company
	  	
			
	By:	  	Bixby SPE Finance, LLC,	  	
		  	a Delaware limited liability company	  	
		  	its sole Member and Manager	  	
				
		  	By:	  	Bixby Land Company,	  	
		  		  	a California corporation	  	
		  		  	its sole Member and Manager	  	
					
		  		  	By:	  	 /s/ Aaron D. Hill
	  	
		  		  	Name:	  	Aaron D. Hill	  	
		  		  	Title:	  	President	  	
					
		  		  	By:	  	 /s/ Martin T. O’Hea
	  	
		  		  	Name:	  	Martin T. O’Hea	  	
		  		  	Title:	  	Executive Vice President and CFO	  	

 [TENANT’S SIGNATURE ON NEXT PAGE] 

  
 S-1 

 IN WITNESS WHEREOF, Tenant has executed this Amendment as of the day and year first
above written. 
  

			
	TENANT:
	
	 SI-BONE, INC.,

a Delaware corporation

		
	By:	 	 /s/ Jeffrey W. Dunn

	Name:	 	Jeffrey W. Dunn
	Title:	 	President, CEO and Chairman
		
	By:	 	 /s/ Michael Pisetsky

	Name:	 	Michael Pisetsky
	Title:	 	VP & General Counsel
	
	
      26-2216351

	Tenant’s Tax ID Number (SSN or FEIN)

  
 S-2 

 EXHIBIT A 

MONTHLY AMORTIZATION SCHEDULE 
  

									
	 Loan Amount
	  	 	100,000.00	 	 	 	100,000.00	 
	 N (years / mos.)
	  	 	7.1666667	 	 	 	86.00000	 
	 I (annual / monthly)
	  	 	8.00	% 	 	 	0.67	% 
	 PMT
	  				 	 	1,531.57	 

  

																											
	 	 	 	Month	 	 	Beg. Balance	 	 	Payment	 	 	Interest	 	  	Principle	 	  	End Balance	 
	 	1	 	 	 	4/1/2018	 	 	 	100,000.00	 	 	 	1,531.57	 	 	 	666.67	 	  	 	864.90	 	  	 	99,135.10	 
	 	2	 	 	 	5/1/2018	 	 	 	99,135.10	 	 	 	1,531.57	 	 	 	660.90	 	  	 	870.67	 	  	 	98,264.43	 
	 	3	 	 	 	6/1/2018	 	 	 	98,264.43	 	 	 	1,531.57	 	 	 	655.10	 	  	 	876.47	 	  	 	97,387.95	 
	 	4	 	 	 	7/1/2018	 	 	 	97,387.95	 	 	 	1,531.57	 	 	 	649.25	 	  	 	882.32	 	  	 	96,505.63	 
	 	5	 	 	 	8/1/2018	 	 	 	96,505.63	 	 	 	1,531.57	 	 	 	643.37	 	  	 	888.20	 	  	 	95,617.44	 
	 	6	 	 	 	9/1/2018	 	 	 	95,617.44	 	 	 	1,531.57	 	 	 	637.45	 	  	 	894.12	 	  	 	94,723.31	 
	 	7	 	 	 	10/1/2018	 	 	 	94,723.31	 	 	 	1,531.57	 	 	 	631.49	 	  	 	900.08	 	  	 	93,823.23	 
	 	8	 	 	 	11/1/2018	 	 	 	93,823.23	 	 	 	1,531.57	 	 	 	625.49	 	  	 	906.08	 	  	 	92,917.15	 
	 	9	 	 	 	12/1/2018	 	 	 	92,917.15	 	 	 	1,531.57	 	 	 	619.45	 	  	 	912.12	 	  	 	92,005.03	 
	 	10	 	 	 	1/1/2019	 	 	 	92,005.03	 	 	 	1,531.57	 	 	 	613.37	 	  	 	918.20	 	  	 	91,086.82	 
	 	11	 	 	 	2/1/2019	 	 	 	91,086.82	 	 	 	1,531.57	 	 	 	607.25	 	  	 	924.32	 	  	 	90,162.50	 
	 	12	 	 	 	3/1/2019	 	 	 	90,162.50	 	 	 	1,531.57	 	 	 	601.08	 	  	 	930.49	 	  	 	89,232.01	 
	 	13	 	 	 	4/1/2019	 	 	 	89,232.01	 	 	 	1,531.57	 	 	 	594.88	 	  	 	936.69	 	  	 	88,295.32	 
	 	14	 	 	 	5/1/2019	 	 	 	88,295.32	 	 	 	1,531.57	 	 	 	588.64	 	  	 	942.93	 	  	 	87,352.39	 
	 	15	 	 	 	6/1/2019	 	 	 	87,352.39	 	 	 	1,531.57	 	 	 	582.35	 	  	 	949.22	 	  	 	86,403.17	 
	 	16	 	 	 	7/1/2019	 	 	 	86,403.17	 	 	 	1,531.57	 	 	 	576.02	 	  	 	955.55	 	  	 	85,447.62	 
	 	17	 	 	 	8/1/2019	 	 	 	85,447.62	 	 	 	1,531.57	 	 	 	569.65	 	  	 	961.92	 	  	 	84,485.70	 
	 	18	 	 	 	9/1/2019	 	 	 	84,485.70	 	 	 	1,531.57	 	 	 	563.24	 	  	 	968.33	 	  	 	83,517.36	 
	 	19	 	 	 	10/1/2019	 	 	 	83,517.36	 	 	 	1,531.57	 	 	 	556.78	 	  	 	974.79	 	  	 	82,542.58	 
	 	20	 	 	 	11/1/2019	 	 	 	82,542.58	 	 	 	1,531.57	 	 	 	550.28	 	  	 	981.29	 	  	 	81,561.29	 
	 	21	 	 	 	12/1/2019	 	 	 	81,561.29	 	 	 	1,531.57	 	 	 	543.74	 	  	 	987.83	 	  	 	80,573.46	 
	 	22	 	 	 	1/1/2020	 	 	 	80,573.46	 	 	 	1,531.57	 	 	 	537.16	 	  	 	994.41	 	  	 	79,579.05	 
	 	23	 	 	 	2/1/2020	 	 	 	79,579.05	 	 	 	1,531.57	 	 	 	530.53	 	  	 	1,001.04	 	  	 	78,578.00	 
	 	24	 	 	 	3/1/2020	 	 	 	78,578.00	 	 	 	1,531.57	 	 	 	523.85	 	  	 	1,007.72	 	  	 	77,570.29	 
	 	25	 	 	 	4/1/2020	 	 	 	77,570.29	 	 	 	1,531.57	 	 	 	517.14	 	  	 	1,014.44	 	  	 	76,555.85	 
	 	26	 	 	 	5/1/2020	 	 	 	76,555.85	 	 	 	1,531.57	 	 	 	510.37	 	  	 	1,021.20	 	  	 	75,534.65	 
	 	27	 	 	 	6/1/2020	 	 	 	75,534.65	 	 	 	1,531.57	 	 	 	503.56	 	  	 	1,028.01	 	  	 	74,506.65	 
	 	28	 	 	 	7/1/2020	 	 	 	74,506.65	 	 	 	1,531.57	 	 	 	496.71	 	  	 	1,034.86	 	  	 	73,471.79	 
	 	29	 	 	 	8/1/2020	 	 	 	73,471.79	 	 	 	1,531.57	 	 	 	489.81	 	  	 	1,041.76	 	  	 	72,430.03	 
	 	30	 	 	 	9/1/2020	 	 	 	72,430.03	 	 	 	1,531.57	 	 	 	482.87	 	  	 	1,048.70	 	  	 	71,381.33	 
	 	31	 	 	 	10/1/2020	 	 	 	71,381.33	 	 	 	1,531.57	 	 	 	475.88	 	  	 	1,055.69	 	  	 	70,325.63	 
	 	32	 	 	 	11/1/2020	 	 	 	70,325.63	 	 	 	1,531.57	 	 	 	468.84	 	  	 	1,062.73	 	  	 	69,262.90	 
	 	33	 	 	 	12/1/2020	 	 	 	69,262.90	 	 	 	1,531.57	 	 	 	461.75	 	  	 	1,069.82	 	  	 	68,193.08	 
	 	34	 	 	 	1/1/2021	 	 	 	68,193.08	 	 	 	1,531.57	 	 	 	454.62	 	  	 	1,076.95	 	  	 	67,116.13	 
	 	35	 	 	 	2/1/2021	 	 	 	67,116.13	 	 	 	1,531.57	 	 	 	447.44	 	  	 	1,084.13	 	  	 	66,032.00	 
	 	36	 	 	 	3/1/2021	 	 	 	66,032.00	 	 	 	1,531.57	 	 	 	440.21	 	  	 	1,091.36	 	  	 	64,940.64	 
	 	37	 	 	 	4/1/2021	 	 	 	64,940.64	 	 	 	1,531.57	 	 	 	432.94	 	  	 	1,098.63	 	  	 	63,842.01	 
	 	38	 	 	 	5/1/2021	 	 	 	63,842.01	 	 	 	1,531.57	 	 	 	425.61	 	  	 	1,105.96	 	  	 	62,736.05	 
	 	39	 	 	 	6/1/2021	 	 	 	62,736.05	 	 	 	1,531.57	 	 	 	418.24	 	  	 	1,113.33	 	  	 	61,622.72	 

  
 Exhibit A 

-1- 

																											
	 	40	 	 	 	7/1/2021	 	 	 	61,622.72	 	 	 	1,531.57	 	 	 	410.82	 	  	 	1,120.75	 	  	 	60,501.97	 
	 	41	 	 	 	8/1/2021	 	 	 	60,501.97	 	 	 	1,531.57	 	 	 	403.35	 	  	 	1,128.22	 	  	 	59,373.75	 
	 	42	 	 	 	9/1/2021	 	 	 	59,373.75	 	 	 	1,531.57	 	 	 	395.82	 	  	 	1,135.75	 	  	 	58,238.00	 
	 	43	 	 	 	10/1/2021	 	 	 	58,238.00	 	 	 	1,531.57	 	 	 	388.25	 	  	 	1,143.32	 	  	 	57,094.69	 
	 	44	 	 	 	11/1/2021	 	 	 	57,094.69	 	 	 	1,531.57	 	 	 	380.63	 	  	 	1,150.94	 	  	 	55,943.75	 
	 	45	 	 	 	12/1/2021	 	 	 	55,943.75	 	 	 	1,531.57	 	 	 	372.96	 	  	 	1,158.61	 	  	 	54,785.13	 
	 	46	 	 	 	1/1/2022	 	 	 	54,785.13	 	 	 	1,531.57	 	 	 	365.23	 	  	 	1,166.34	 	  	 	53,618.80	 
	 	47	 	 	 	2/1/2022	 	 	 	53,618.80	 	 	 	1,531.57	 	 	 	357.46	 	  	 	1,174.11	 	  	 	52,444.69	 
	 	48	 	 	 	3/1/2022	 	 	 	52,444.69	 	 	 	1,531.57	 	 	 	349.63	 	  	 	1,181.94	 	  	 	51,262.75	 
	 	49	 	 	 	4/1/2022	 	 	 	51,262.75	 	 	 	1,531.57	 	 	 	341.75	 	  	 	1,189.82	 	  	 	50,072.93	 
	 	50	 	 	 	5/1/2022	 	 	 	50,072.93	 	 	 	1,531.57	 	 	 	333.82	 	  	 	1,197.75	 	  	 	48,875.18	 
	 	51	 	 	 	6/1/2022	 	 	 	48,875.18	 	 	 	1,531.57	 	 	 	325.83	 	  	 	1,205.74	 	  	 	47,669.44	 
	 	52	 	 	 	7/1/2022	 	 	 	47,669.44	 	 	 	1,531.57	 	 	 	317.80	 	  	 	1,213.77	 	  	 	46,455.67	 
	 	53	 	 	 	8/1/2022	 	 	 	46,455.67	 	 	 	1,531.57	 	 	 	309.70	 	  	 	1,221.87	 	  	 	45,233.80	 
	 	54	 	 	 	9/1/2022	 	 	 	45,233.80	 	 	 	1,531.57	 	 	 	301.56	 	  	 	1,230.01	 	  	 	44,003.79	 
	 	55	 	 	 	10/1/2022	 	 	 	44,003.79	 	 	 	1,531.57	 	 	 	293.36	 	  	 	1,238.21	 	  	 	42,765.58	 
	 	56	 	 	 	11/1/2022	 	 	 	42,765.58	 	 	 	1,531.57	 	 	 	285.10	 	  	 	1,246.47	 	  	 	41,519.11	 
	 	57	 	 	 	12/1/2022	 	 	 	41,519.11	 	 	 	1,531.57	 	 	 	276.79	 	  	 	1,254.78	 	  	 	40,264.33	 
	 	58	 	 	 	1/1/2023	 	 	 	40,264.33	 	 	 	1,531.57	 	 	 	268.43	 	  	 	1,263.14	 	  	 	39,001.19	 
	 	59	 	 	 	2/1/2023	 	 	 	39,001.19	 	 	 	1,531.57	 	 	 	260.01	 	  	 	1,271.56	 	  	 	37,729.63	 
	 	60	 	 	 	3/1/2023	 	 	 	37,729.63	 	 	 	1,531.57	 	 	 	251.53	 	  	 	1,280.04	 	  	 	36,449.59	 
	 	61	 	 	 	4/1/2023	 	 	 	36,449.59	 	 	 	1,531.57	 	 	 	243.00	 	  	 	1,288.57	 	  	 	35,161.02	 
	 	62	 	 	 	5/1/2023	 	 	 	35,161.02	 	 	 	1,531.57	 	 	 	234.41	 	  	 	1,297.16	 	  	 	33,863.85	 
	 	63	 	 	 	6/1/2023	 	 	 	33,863.85	 	 	 	1,531.57	 	 	 	225.76	 	  	 	1,305.81	 	  	 	32,558.04	 
	 	64	 	 	 	7/1/2023	 	 	 	32,558.04	 	 	 	1,531.57	 	 	 	217.05	 	  	 	1,314.52	 	  	 	31,243.53	 
	 	65	 	 	 	8/1/2023	 	 	 	31,243.53	 	 	 	1,531.57	 	 	 	208.29	 	  	 	1,323.28	 	  	 	29,920.25	 
	 	66	 	 	 	9/1/2023	 	 	 	29,920.25	 	 	 	1,531.57	 	 	 	199.47	 	  	 	1,332.10	 	  	 	28,588.14	 
	 	67	 	 	 	10/1/2023	 	 	 	28,588.14	 	 	 	1,531.57	 	 	 	190.59	 	  	 	1,340.98	 	  	 	27,247.16	 
	 	68	 	 	 	11/1/2023	 	 	 	27,247.16	 	 	 	1,531.57	 	 	 	181.65	 	  	 	1,349.92	 	  	 	25,897.24	 
	 	69	 	 	 	12/1/2023	 	 	 	25,897.24	 	 	 	1,531.57	 	 	 	172.65	 	  	 	1,358.92	 	  	 	24,538.32	 
	 	70	 	 	 	1/1/2024	 	 	 	24,538.32	 	 	 	1,531.57	 	 	 	163.59	 	  	 	1,367.98	 	  	 	23,170.33	 
	 	71	 	 	 	2/1/2024	 	 	 	23,170.33	 	 	 	1,531.57	 	 	 	154.47	 	  	 	1,377.10	 	  	 	21,793.23	 
	 	72	 	 	 	3/1/2024	 	 	 	21,793.23	 	 	 	1,531.57	 	 	 	145.29	 	  	 	1,386.28	 	  	 	20,406.95	 
	 	73	 	 	 	4/1/2024	 	 	 	20,406.95	 	 	 	1,531.57	 	 	 	136.05	 	  	 	1,395.52	 	  	 	19,011.43	 
	 	74	 	 	 	5/1/2024	 	 	 	19,011.43	 	 	 	1,531.57	 	 	 	126.74	 	  	 	1,404.83	 	  	 	17,606.60	 
	 	75	 	 	 	6/1/2024	 	 	 	17,606.60	 	 	 	1,531.57	 	 	 	117.38	 	  	 	1,414.19	 	  	 	16,192.41	 
	 	76	 	 	 	7/1/2024	 	 	 	16,192.41	 	 	 	1,531.57	 	 	 	107.95	 	  	 	1,423.62	 	  	 	14,768.79	 
	 	77	 	 	 	8/1/2024	 	 	 	14,768.79	 	 	 	1,531.57	 	 	 	98.46	 	  	 	1,433.11	 	  	 	13,335.67	 
	 	78	 	 	 	9/1/2024	 	 	 	13,335.67	 	 	 	1,531.57	 	 	 	88.90	 	  	 	1,442.67	 	  	 	11,893.01	 
	 	79	 	 	 	10/1/2024	 	 	 	11,893.01	 	 	 	1,531.57	 	 	 	79.29	 	  	 	1,452.28	 	  	 	10,440.72	 
	 	80	 	 	 	11/1/2024	 	 	 	10,440.72	 	 	 	1,531.57	 	 	 	69.60	 	  	 	1,461.97	 	  	 	8,978.76	 
	 	81	 	 	 	12/1/2024	 	 	 	8,978.76	 	 	 	1,531.57	 	 	 	59.86	 	  	 	1,471.71	 	  	 	7,507.05	 
	 	82	 	 	 	1/1/2025	 	 	 	7,507.05	 	 	 	1,531.57	 	 	 	50.05	 	  	 	1,481.52	 	  	 	6,025.52	 
	 	83	 	 	 	2/1/2025	 	 	 	6,025.52	 	 	 	1,531.57	 	 	 	40.17	 	  	 	1,491.40	 	  	 	4,534.12	 
	 	84	 	 	 	3/1/2025	 	 	 	4,534.12	 	 	 	1,531.57	 	 	 	30.23	 	  	 	1,501.34	 	  	 	3,032.78	 
	 	85	 	 	 	4/1/2025	 	 	 	3,032.78	 	 	 	1,531.57	 	 	 	20.22	 	  	 	1,511.35	 	  	 	1,521.43	 
	 	86	 	 	 	5/1/2025	 	 	 	1,521.43	 	 	 	1,531.57	 	 	 	10.14	 	  	 	1,521.43	 	  	 	0.00	 

  
 Exhibit A 

-2-

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00287-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00287-of-00352.parquet"}]]