Document:

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[CHIRON LETTERHEAD]

February 14, 2001

PERSONAL AND CONFIDENTIAL

Dr. William J. Rutter
111 Telegraph Hill Blvd.
San Francisco, California 94133

Re:  AMENDMENT OF CONSULTING AGREEMENT DATED FEBRUARY 25, 2000
     ---------------------------------------------------------

Dear Bill,

I am pleased to confirm our discussions to extend your agreement to work with
Chiron Corporation through February 24, 2002.

Your fee will be $8,333.33 per month, payable to you monthly in advance, for the
period commencing on February 25, 2001 and terminating on February 24, 2002.

In addition, the field of the agreement is hereby amended to cover advice and
consultation from time to time to the Chairman and Chief Executive Officer with
respect to corporate and strategic matters.

Please acknowledge your acceptance and agreement to the foregoing by signing and
returning to me a copy of the enclosed letter.

Yours sincerely,

/s/ Sean
Sean P. Lance
Chairman and Chief Executive Officer

AGREED THIS 20th DAY OF FEBRUARY 2001.

/s/ William J. Rutter
---------------------------------------
William J. Rutter, Ph.D.<PAGE>

[CHIRON LETTERHEAD]

                                                     Direct Dial: (510) 923-2905
                                                     Law Department

December 6, 2000

VIA FACSIMILE AND FEDERAL EXPRESS
212-830-2495

Novartis Corporation
564 Morris Avenue
Summit, NJ 07901

Attn:    Jeff Benjamin
         Vice President and Associate
         General Counsel

Dear Sirs:

This letter confirms the agreement between Chiron Corporation ("Chiron") on
behalf of itself and its wholly-owned subsidiary Chiron SpA, on the none hand,
and Novartis Corporation ("Novartis") to amend that certain Limited Liability
Company Agreement between them, dated as of December 28,1995,as amended (the
"LLC Agreement") in certain respects. Terms not defined in this letter shall
have the meanings set forth in the LLC Agreement.

1.   Section 2.3.1 of the LLC Agreement shall be amended to extend the date
     through which Chiron may sell Units of Membership Interest to Novartis from
     December 31, 2000 to December 31 2001 and thereby extending the period of
     time within which Chiron may apply the proceeds of the sale of such Units
     to offset the R&D Costs of the Funded Projects.

2.   Section 2.3.3 of the LLC agreement shall be amended to replace subsection
     (f) with the following:

" (f) in 2000, any unused portion of the funding limit for 1999, but in no event
more than Nineteen million three hundred thousand dollars (US $19,300,000) and
(g) in 2001, any unused portion of the funding limit for 2000, but in no event
more than Twelve million one hundred thousand dollars (US $12,100,000) so that
the total funding amount does not exceed Two hundred sixty five million dollars
(US $265,000,000)."

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If the foregoing accurately reflects our understanding effective as of the date
of this letter, please sign and return one copy to me.

Very truly yours
CHIRON CORPORATION

     /s/ William G. Green
By:  William G. Green
     Senior Vice President and General Counsel

Agreed:
NOVARTIS CORPORATION

By:   /s/ Jeff Benjamin

Its:  Vice President & Associate General Counsel

cc:  Herbert Gut
     Joseph Mamie<PAGE>

                                                                     EXHIBIT 4.1

UNLESS THIS NOTE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITORY
TRUST COMPANY (THE "DEPOSITARY") (55 WATER STREET, NEW YORK, NEW YORK) TO THE
ISSUER HEREOF OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT,
AND ANY NOTE ISSUED IS REGISTERED IN THE NAME OF CEDE & CO. OR SUCH OTHER NAME
AS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF THE DEPOSITARY AND ANY PAYMENT
IS MADE TO CEDE & CO., ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR
OTHERWISE BY OR TO ANY PERSON IS WRONGFUL SINCE THE REGISTERED OWNER HEREOF,
CEDE & CO., HAS AN INTEREST HEREIN.

UNLESS AND UNTIL IT IS EXCHANGED IN WHOLE OR IN PART FOR NOTES IN CERTIFICATED
FORM, THIS NOTE MAY NOT BE TRANSFERRED EXCEPT AS A WHOLE BY THE DEPOSITARY TO A
NOMINEE OF THE DEPOSITARY OR BY A NOMINEE OF THE DEPOSITARY TO THE DEPOSITARY OR
ANOTHER NOMINEE OF THE DEPOSITARY OR BY THE DEPOSITARY OR ANY SUCH NOMINEE TO A
SUCCESSOR DEPOSITARY OR A NOMINEE OF SUCH SUCCESSOR DEPOSITARY.

REGISTERED                                                      PRINCIPAL AMOUNT
No. __                                                          $_______________
CUSIP No. 097014 AD 6
ISIN: US097014AD62
COMMON CODE: 012605153

                           BOEING CAPITAL CORPORATION

                           6.10% Senior Notes due 2011

     BOEING CAPITAL CORPORATION, a Delaware corporation (hereinafter called the
"Company," which term includes any successor corporation under the Indenture
referred to below), for value received, hereby promises to pay to Cede & Co., or
registered assigns, the principal sum of _____________ DOLLARS ($____________)
on March 1, 2011 (the "Maturity Date"), unless previously redeemed, and to pay
interest thereon from March 8, 2001 or from the most recent interest payment
date to which interest has been paid or duly provided for, payable semiannually
on March 1 and September 1 of each year (each, an "Interest Payment Date"),
commencing September 1, 2001, at the rate of 6.10% per annum, until the
principal hereof is paid or duly made available for payment. Interest shall be
computed on the basis of a 360 day year of 12 30-day months. Interest payable on
each Interest Payment Date shall equal the amount of interest accrued for the
period commencing on and including the immediately preceding Interest Payment
Date in respect of which interest has been paid (or commencing on and including
March 8, 2001, if no interest has been paid hereon) and ending on and including
the day preceding such Interest Payment Date. Interest shall be payable to the
person in whose name this Note is registered at the close of business on the
February 15 and August 15 prior to the related Interest Payment Date. Any such
interest which is payable, but is not punctually paid or duly provided for, on
any Interest Payment Date shall forthwith cease to be payable to the

<PAGE>

registered Holder (as defined below) hereof on the relevant regular record date
by virtue of having been such Holder, and may be paid to the Person in whose
name this Note (or one or more predecessor securities) is registered at the
close of business on a subsequent Special Record Date (which shall be fixed in
accordance with the provisions of the Indenture) for the payment of such
defaulted interest to be fixed by the Trustee, notice whereof shall be given to
the Holders of Notes of this series not less than 10 days prior to such Special
Record Date, or may be paid at any time in any other lawful manner not
inconsistent with the requirements of any securities exchange on which the Notes
may be listed, and upon such notice as may be required by such exchange, all as
more fully provided in such Indenture. If any Interest Payment Date or the
Maturity Date or any date fixed for redemption (the "Redemption Date") falls on
a day which is not a Business Day, the required payment shall be paid on the
next succeeding Business Day with the same force and effect as if made on such
date and no interest on such payment shall accrue from and after such date.
"Business Day" shall mean any day, other than a Saturday or Sunday, that is
neither a legal holiday nor a day on which commercial banks are authorized or
required by law, regulation or executive order to close in The City of New York.
Payments of principal and interest hereunder shall be made in such coin or
currency of the United States of America as at the time of payment shall be
legal tender for the payment of public and private debts and shall be made
immediately available to the Holder hereof.

     This Note is one of the duly authorized series of Securities of the
Company, designated as the Company's "6.10% Senior Notes due 2011" (the
"Notes"), initially issued in an aggregate principal amount of $750,000,000, all
issued or to be issued under and pursuant to an Indenture dated as of August 31,
2000, as amended, modified or supplemented from time to time (as so amended,
modified or supplemented, the "Indenture"), duly executed and delivered by the
Company to Bankers Trust Company, as trustee (hereinafter referred to as the
"Trustee"), to which Indenture and all indentures supplemental thereto reference
is hereby made for a description of the rights, limitation of rights,
obligations, duties and immunities thereunder of the Trustee, the Company and
the Holders (the words "Holders" or "Holder" meaning the registered holders or
registered holder of the Notes).

     The Company shall, subject to the exceptions and limitations set forth
below, pay as additional interest on the Notes, such additional amounts
("Additional Amounts") as are necessary in order that the net payment by the
Company of the principal of and interest on this Note to a Holder who is a
Non-United States Person (as defined below), after deduction for any present or
future tax, assessment or other governmental charge of the United States or a
political subdivision or taxing authority thereof or therein, imposed by
withholding with respect to the payment, shall not be less than the amount
provided in this Note to be then due and payable; provided, however, that the
foregoing obligation to pay Additional Amounts shall not apply: (1) to any tax,
assessment or other governmental charge that is imposed or withheld solely by
reason of the Holder, or a fiduciary, settlor, beneficiary, member or
shareholder of such Holder if such Holder is an estate, trust, partnership or
corporation, or a person holding a power over an estate or trust administered by
a fiduciary holder, being considered as: (a) being or having been present or
engaged in a trade or business in the United States or having had a permanent
establishment in the United States; (b) having a current or former relationship
with the United States, including a relationship as a citizen or resident
thereof; (c) being or having been a foreign or domestic personal holding
company, a passive foreign investment company or a controlled foreign
corporation with respect to the United States or a corporation that has
accumulated earnings to

                                       2
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avoid United States federal income tax; (d) being or having been a "10-percent
shareholder" of the Company as defined in Section 871(h)(3) of the United States
Internal Revenue Code of 1986, as amended, or any successor provision; or (e)
being a bank receiving payments on an extension of credit made pursuant to a
loan agreement entered into in the ordinary course of its trade or business; (2)
to any Holder that is not the sole beneficial owner of a Note, or a portion
thereof, or that is a fiduciary or partnership, but only to the extent that a
beneficiary or settlor with respect to the fiduciary, a beneficial owner or
member of the partnership would not have been entitled to the payment of an
Additional Amount had the beneficiary, settlor, beneficial owner or member
received directly its beneficial or distributive share of the payment; (3) to
any tax, assessment or other governmental charge that is imposed or withheld by
reason of the failure of the Holder or any other person to comply with
certification, identification or information reporting requirements concerning
the nationality, residence, identity or connection with the United States, or
otherwise with respect to the status, of the holder or Holder of this Note (or
any beneficiary, settlor, beneficial owner or member thereof), if compliance is
required by statute, by regulation of the United States Treasury Department or
by an applicable income tax treaty to which the United States is a party, or by
any official interpretation or ruling promulgated pursuant to any of the
foregoing, as a precondition to exemption from such tax, assessment or other
governmental charge; (4) to any tax, assessment or other governmental charge
that is imposed otherwise than by withholding by the Company or its payment
agent from the payment; (5) to any tax, assessment or other governmental charge
that is imposed or withheld solely by reason of a change in law, regulation, or
administrative or judicial interpretation that becomes effective after the
payment becomes due or is duly provided for, whichever occurs later; (6) to any
estate, inheritance, gift, sales, excise, transfer, wealth or personal property
tax or similar tax, assessment or other governmental charge; (7) to any tax,
assessment or other governmental charge required to be withheld by any paying
agent of the Company from any payment of principal of or interest on this Note,
if such payment can be made without such withholding by any other paying agent
of the Company; or (8) in the case of any combination of items (1), (2), (3),
(4), (5), (6) and (7). The Notes are subject in all cases to any tax, fiscal or
other law or regulation or administrative or judicial interpretation applicable
thereto. Except as specifically provided herein, the Company shall not be
required to make any payment with respect to any tax, assessment or other
governmental charge imposed by any government or a political subdivision or
taxing authority thereof or therein.

     As used herein, the term "United States" shall mean the United States of
America (including the States and the District of Columbia) and its territories,
its possessions and other areas subject to its jurisdiction, and the term
"United States Person" shall mean any individual who is a citizen or resident of
the United States, a corporation, partnership (or any other entity treated as a
corporation or partnership for United States federal income tax purposes)
created or organized in or under the laws of the United States, any State
thereof or the District of Columbia (other than a partnership that is not
treated as a United States Person under any applicable Treasury regulations),
any estate the income of which is subject to United States federal income
taxation regardless of its source, or any trust if a court within the United
States is able to exercise primary supervision over the administration of the
trust and one or more United States Persons have the authority to control all
substantial decisions of the trust. Notwithstanding the preceding sentence, to
the extent provided in the Treasury regulations, certain trusts in existence on
August 20, 1996, and treated as United States Persons prior to such date that
elect to continue to be

                                       3
<PAGE>

treated as United States Persons, will also be United States Persons.
"Non-United States Person" shall mean a person who is not a United States
Person.

     If, as a result of any change in, or amendment to, the laws (or any
regulations or rulings promulgated thereunder) of the United States (or any
political subdivision or taxing authority thereof or therein), or any change in,
or amendments to, an official position regarding the application or
interpretation of such laws, regulations or rulings, which change or amendment
is announced or becomes effective on or after March 8, 2001, the Company becomes
or, based upon a written opinion of independent counsel selected by the Company,
shall become obligated to pay Additional Amounts, the Company may, at its
option, redeem, as a whole, but not in part, this Note on not less than 30 nor
more than 60 days' prior notice, at a redemption price equal to 100% of the
principal amount of the Notes together with interest accrued but unpaid thereon
to the Redemption Date. Other than as set forth in this paragraph, the Notes
shall not be subject to redemption at the option of the Company.

     Notice of any redemption will be mailed not less than 30 nor more than 60
calendar days before the Redemption Date to the Holder hereof at its registered
address. Unless the Company defaults in payment of the redemption price, on and
after the Redemption Date interest will cease to accrue on the principal amount
of this Note.

     If money sufficient to pay the redemption price with respect to this Note
on the Redemption Date is deposited with the Trustee on or before the Redemption
Date and certain other conditions are satisfied, then on and after such date,
interest will cease to accrue on the principal amount of this Note.

     The Company may, without notice to, or the consent of, the holders of the
Notes, create and issue further Notes, equal in rank to the Notes in all
respects (or in all respects except for the payment of interest accruing prior
to the issue date of the new securities or except for the first payment of
interest following the issue date of the new securities) so that the new
securities may be consolidated and form a single series with the Notes and have
the same terms as to status, redemption or otherwise as the Notes.

     This Note is not subject to any sinking fund.

     In case an Event of Default shall occur and be continuing, the principal
hereof may be declared, and upon such declaration shall become, due and payable,
in the manner, with the effect and subject to the conditions provided in the
Indenture.

     The Indenture permits, with certain exceptions as therein provided, the
amendment thereof and the modification of the rights and obligations of the
Company and the rights of the holders of the Notes at any time by the Company
and the Trustee with the consent of the holders of not less than 66-2/3% in
principal amount of the outstanding Notes. The Indenture also contains
provisions permitting the holders of at least 66-2/3% in principal amount of the
outstanding Notes, on behalf of the holders of all of the Notes, to waive
compliance by the Company with certain provisions of the Indenture. Furthermore,
provisions in the Indenture permit the holders of not less than a majority in
principal amount of the outstanding Notes, in certain instances, to waive, on
behalf of all of the Holders of the Notes, certain past defaults under the
Indenture and

                                       4
<PAGE>

their consequences. Any such consent or waiver by the Holder of this Note shall
be conclusive and binding upon such Holder and upon all future Holders of this
Note and other Notes issued upon the registration of transfer hereof or in
exchange herefor or in lieu hereof, whether or not notation of such consent or
waiver is made upon this Note.

     Subject to certain conditions, the Company at any time may terminate some
or all of its obligations under the Notes and the Indenture if the Company
deposits with the Trustee money or U.S Government Obligations for the payment of
principal and interest on the Notes to the Maturity Date.

     If money for the payment of principal or interest remains unclaimed for one
year, the Trustee or Paying Agent shall pay the money back to the Company at its
request unless an abandoned property law designates another Person. After any
such payment, Holders entitled to the money must look only to the Company and
not to the Trustee for payment.

     No reference herein to the Indenture and no provision of this Note or of
the Indenture shall alter or impair the obligation of the Company, which is
absolute and unconditional, to pay the principal of and interest on this Note at
the place, at the respective times, at the rate, and in the coin or currency
herein prescribed.

     No director, officer, employee or stockholder, as such, of the Company
shall have any liability for any obligations of the Company under this Note or
the Indenture or for any claim based on, in respect of or by reason of such
obligations or their creation. Each Holder, by accepting this Note, waives and
releases all such liability. The waiver and release are part of the
consideration for the issue of this Note.

     This Note and the Indenture shall be deemed to be New York contracts, and
for all purposes shall be construed in accordance with the laws of said State
(without reference to principles of conflicts of law).

     Ownership of this Note shall be proved by the register for the Notes kept
by the Registrar. The Company, the Trustee and any agent of the Company may
treat the person in whose name a Note is registered as the absolute owner
thereof for all purposes.

     Terms used herein without definition that are defined in the Indenture
shall have the meanings assigned to them in the Indenture.

     Unless the Certificate of Authentication hereon has been executed by the
Trustee under the Indenture referred to herein by the manual signature of one of
its authorized officers, or on behalf of the Trustee by the manual signature of
an authorized officer of the Trustee's authenticating agent, this Note shall not
be entitled to any benefit under the Indenture or be valid or obligatory for any
purpose.

                                       5
<PAGE>

     IN WITNESS WHEREOF, the Company has caused this instrument to be duly
executed, manually or in facsimile, and an imprint or facsimile of its corporate
seal to be imprinted hereon.

Dated: March 8, 2001

[SEAL]                                     BOEING CAPITAL CORPORATION

                                           By:   _______________________________
                                                 Name:
                                                 Title:
Attest:

By:___________________________
      Name:
      Title:

Dated: March 8, 2001

TRUSTEE'S CERTIFICATE OF AUTHENTICATION:

This is one of the Securities of the series
designated therein referred to in
the within-mentioned Indenture.

BANKERS TRUST COMPANY,
as Trustee

By:____________________________
        Authorized Officer

                                       6
<PAGE>

                                 ASSIGNMENT FORM

FOR VALUE RECEIVED, the undersigned hereby sell(s), assign(s) and transfer(s)
unto

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Please insert social security number or other identifying number of assignee:

--------------------------------

Please print or type name and address (including zip code) of assignee:

--------------------------------

--------------------------------

--------------------------------

--------------------------------

the within Note and all rights thereunder, hereby irrevocably constituting and
appointing _____________________ attorney to transfer said Note of Boeing
Capital Corporation on the books of Boeing Capital Corporation with full power
of substitution in the premises.

--------------------------------

Dated:
      --------------------------

     NOTICE: The signature to this assignment must correspond with the name as
written upon the face of this Note in every particular without alteration or
enlargement or any change whatsoever. The Signature must be guaranteed by an
"eligible guarantor institution meeting the requirements of the Registrar, which
requirements include memberships or participation in the Security Transfer Agent
Medallion Program ("STAMP") or such other "signature guarantee program" as may
be determined by the Registrar in addition to, or in substitution for, STAMP,
all in accordance with the Securities Exchange Act or 1934.

                                       7

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