Document:

OPTION TERM SHEET

Pursuant to the terms and  conditions of your Offer of  Employment  dated August
19,  1998,  you have  been  granted a  Non-Qualified  Stock  Option to  purchase
2,050,000 shares of CYTOGEN Common Stock as outlined below:

                  Granted To:               H. Joseph Reiser
                                            SSN ###-##-####

1.  700,000 shares upon date of hire:

         Grant Date:                       August 24, 1998
         Options Granted:                  2,050,000
         Option Price Per Share:           $1.0937
         Expiration Date:                  August 24, 2008
         Vesting Schedule:                 100,000 on 11/17/98
                                           150,000 on 5/18/00
                                           300,000 on 8/24/00
                                           75,000 on 11/22/00
                                           150,000 on 5/15/01
                                           150,000 on 5/18/01
                                           300,000 on 8/24/01
                                           75,000 on 11/22/01
                                           150,000 on 5/15/02
                                           150,000 on 5/18/02
                                           75,000 on 11/22/01
                                           150,000 on 5/15/03
                                           225,000 vesting subject to additional
                                           approval of the Board of Directors

By my signature below, I hereby acknowledge receipt of these Option terms, which
have been issued to me under the terms and  conditions of my Offer of Employment
dated August 19, 1998.

                                             Date:
--------------------------------                  ----------------------
H. Joseph Reiser

(As revised by the Board of Directors on July 11, 2000)
<PAGE>
                               CYTOGEN CORPORATION

                      NON-QUALIFIED STOCK OPTION AGREEMENT

     1. Grant of Option.  Subject to  all the  terms and  conditions  hereof and
        ---------------
the option term sheet attached hereto and made a part hereof (the "Term Sheet"),
the Company hereby grants to the Employee an option (the "Option"),  to purchase
shares of the Company's  Common Stock.  The Option is not intended to qualify as
an  Incentive  Stock  Option  within the meaning of Section 422A of the Internal
Revenue Code of 1986, as amended (the "Code"). In the event of any inconsistency
in the terms hereof and the terms of the Term Sheet, the terms of the Term Sheet
shall govern.

     2. Exercise of Option.
        ------------------

          2.1 Exercisability of Option.
              ------------------------

               2.1.1 Except as provided in Sections 2.1.2,  2.1.3, and 2.2, this
Option shall be exercisable only in accordance with the following schedule:

  Number of Years                           Percentage of Option Shares
Since Date of Grant                      Available for Purchase (Cumulative)
-------------------                      -----------------------------------

Less than one                                             0.0%
One but fewer than Two                                   33.3
Two but fewer than Three                                 66.6
Three or more                                           100.0

               2.1.2 If, prior to the Expiration Date, the Employee's employment
terminates  because of death or Total  Disability as defined below,  this Option
shall become  exercisable,  but only during the applicable  period  specified in
Section 2.4, in accordance with the following schedule:

  Number of Years                           Percentage of Option Shares
Since Date of Grant                      Available for Purchase (Cumulative)
-------------------                      -----------------------------------

Less than one                                              50%
One but fewer than Two                                     50

               2.1.2 (a) The term "Total  Disability"  as used in this Agreement
shall  mean  inability  of an  Employee  to  engage in any  substantial  gainful
activity by reason of a  medically  determinable  physical or mental  impairment
which can be  expected to result in death or which has lasted or can be expected
to last for a continuous period of not less than 12 months.  All  determinations
as to the date and  extent  of  disability  of an  Employee  will be made by the
Committee.

               2.1.3 (a) Upon the occurrence of a Major Event, as defined below,
in addition to those shares  available  for purchase as of the date of the Major
Event all of the  remaining  Option  Shares  not then  otherwise  available  for
purchase as of such date shall become immediately available for purchase.

                     (b) (i) The  term  "Major  Event" as used in this Agreement
shall mean (1) the Company  enters  into one or more  definitive  agreements  to
merge or consolidate the Company with or into another corporation, or to sell or
otherwise  dispose of all or substantially  all of the Company's  assets,  or to
effect any other
                                                                07/00
<PAGE>

transaction,  consolidation or reorganization  having similar results or effect;
(2) any person other than the Company makes a tender or exchange  offer for more
than 50% of Common  Stock  pursuant to which  purchases  of any amount of Common
Stock are made; (3) stock  representing more than 50% of the voting power of the
Company  is  acquired  by any person  other than the  Company in any one or more
transaction(s);  or (4) within any 24-month  period  persons who were members of
the Company's  Board of Directors  immediately  prior to such  24-month  period,
together  with any  persons  who were first  elected as  directors  during  such
24-month  period  by or upon  the  recommendation  of  members  of the  Board of
Directors who were members  immediately  prior to such  24-month  period and who
constituted  a majority of the Board of Directors at the time of such  election,
cease to constitute a majority of the Board of Directors.

          2.2  Expiration  Date.  This  Option  may not be  exercised  after the
               ----------------
Expiration Date.

          2.3 Continuous  Employment Required.  This Option may not be exercised
              -------------------------------
unless on the date of exercise  (i) the Employee  has been  continuously  in the
employment of the Company since the Date of Grant or (ii) the Employee meets the
requirements  of  Section  2.4.  For  the  purposes  of  this   Agreement,   (i)
"employment"  shall have the  meaning  specified  in Section  1.421-7(h)  of the
Income Tax Regulations or any successor regulations,  and (ii) if this Agreement
shall be assumed or a new option agreement substituted therefor in a transaction
to  which  Section  425(a)  of the  Code  or any  successor  provision  applies,
employment by the assuming or substituting  corporation  shall be considered for
all purposes of this Agreement to be employment by the Company.  For purposes of
this Agreement, any leave of absence taken with the consent of the Company for a
period not greater than 90 days shall not be deemed an interruption of otherwise
continuous  employment so long as the  Employee's  right to employment  with the
Company or any Related  Corporation is guaranteed by contract through the period
of leave. If the period of leave exceeds 90 days, and if the Employee's right to
employment  is not  guaranteed  by  contract  through  the period of leave,  the
employment will be deemed terminated as of the first day of the leave.

          2.4 Exercise After Termination of Employment.
              ----------------------------------------

               2.4.1 If the  Employee  ceases to be  employed by the Company for
any reason other than death or Total  Disability,  and provided that through the
date of termination of employment the Employee shall have been  continuously  in
the  employment  of the Company  since the Date of Grant,  the right to exercise
this Option  shall  terminate  three  months  after the date of  termination  of
employment,  but in no event after the Expiration Date.  During that three-month
period, this Option may be exercised only in respect of any or all Option Shares
which were  available for purchase at the date of  termination  of employment as
provided in Section 2.1.1.

               2.4.2 If the  Employee  ceases to be  employed  because  of Total
Disability,  and provided that through the date of termination of employment the
Employee shall have been continuously in the employment of the Company since the
Date of Grant,  the right to exercise this Option shall terminate one year after
the date of  termination  of  employment,  but in no event after the  Expiration
Date.  During  that  one-year  period,  this Option may be  exercised  only with
respect to any

                                       -2-                      07/00
<PAGE>

or  all  Option  Shares  which  were  available  for  purchase  on the  date  of
termination of employment as provided in Section 2.1.2.

               2.4.3 If the  Employee  ceases to be employed by reason of his or
her death,  or dies  following the date of his or her  termination of employment
but at a time when this Option still would be  exercisable  but for the death of
the Employee,  the Option may be exercised by the person or persons to whom this
Option  passed by will or by the laws of  descent  and  distribution  (but by no
other  persons)  until  the  earlier  of (i)  the  end of  the  one-year  period
immediately  following the date of death,  (ii) the Expiration  Date or (iii) if
the death occurs after the  termination of employment,  the end of the period in
which this Option could be exercised under Section 2.4.1 or 2.4.2.

     3. Exercise.
        --------

          3.1 Manner of Exercise.  Subject to the  conditions  set forth in this
              ------------------
Agreement, this Option may be exercised in whole or in part at any time, or from
time to time,  during its term. To exercise this Option,  the Employee (or other
person  entitled to exercise  this Option)  must deliver to the Company,  at its
principal office:

                    (i) a notice of exercise of this  Option,  which  states the
          extent to which this Option is being exercised;

                    (ii) a certified or bank cashier's  check in an amount equal
          to the Exercise  Price of this Option times the number of shares as to
          which it is being  exercised,  or  consideration in such other form as
          may be permitted under the terms on which this Option is granted; and

                    (iii) a  certified  or bank  cashier's  check  equal  to any
          withholding  taxes the  Company  is  required  to pay  because  of the
          exercise of this Option.

The  date on  which  the  Company  receives  all  the  items  specified  in this
subsection  will be the date on which  this  Option is  exercised  to the extent
described in the notice of election.

          3.2 Laws and  Regulations.  The  obligation of the Company to sell and
              ---------------------
deliver  shares of Common  Stock  under  this  Agreement  will be subject to the
condition  that legal  counsel  for the Company be  satisfied  that the sale and
delivery will not violate the Securities  Act of 1933, as amended,  or any other
applicable laws, rules or regulations.

          3.3 Delivery of Stock  Certificates.  As promptly as practicable after
              -------------------------------
this Option is  exercised,  the Company will deliver to the person who exercises
this Option  certificates,  registered in that person's name,  representing  the
number of shares of Common  Stock which were  purchased  by the exercise of this
Option. Each certificate may bear a legend to indicate, if applicable,  that (i)
the Common Stock  represented  by the  certificate  was issued in a  transaction
which was not registered  under the Securities Act of 1933, as amended,  and may
only be sold or transferred in a transaction  which is registered under that Act
or is exempt from the registration requirements of that Act, and (ii) the Common
Stock  represented by the certificate is subject to the obligation of the holder
to pay any unpaid balance of the Exercise

                                       -3-                      07/00
<PAGE>

Price  (whether  pursuant to a promissory  note or  otherwise),  and/or that the
Common Stock is pledged to secure such an obligation.

     4.  Nontransferability of Options.  Except as otherwise expressly provided,
         -----------------------------
this Option may be  exercised  only by the  Employee  or his or her  guardian or
legal  representative  during the  Employee's  lifetime.  This Option may not be
assigned,  pledged or hypothecated in any way, will not be subject to execution,
and will not be  transferable  otherwise than by will or the laws of descent and
distribution.  The Company will not recognize  any attempt to assign,  transfer,
pledge,  hypothecate  or  otherwise  dispose  of  this  Option  contrary  to the
provisions of this  Agreement,  or any levy of any attachment or similar process
upon any Option, and, except as expressly stated herein, the Company will not be
required  to, and will not,  issue  Common  Stock on  exercise of this Option to
anyone who claims to have  acquired this Option from the Employee to whom it was
granted.

     5. No Employment  Rights or Other Employee  Benefits.  Nothing contained in
        ------------------------------------------------
this   Agreement   shall  be  construed  or  deemed  by  any  person  under  any
circumstances to bind the Company to continue the employment of the Employee for
the period within which this Option may be exercised. The amount of any economic
benefit  directly  or  indirectly  realized  by the  Employee as a result of the
exercise of this Option or the sale of shares  received upon such exercise shall
not constitute  "compensation" with respect to which any other employee benefits
of the Employee are determined,  including,  without limitation,  benefits under
any defined  benefit,  defined  contribution,  profit  sharing,  life insurance,
salary contribution or other benefit plans.

     6. Rights as a Stockholder.  Except as otherwise expressly provided in this
        -----------------------
Agreement,  the Employee  shall have no rights as a stockholder  with respect to
any Option  Shares,  unless and until those shares are  purchased in  accordance
with this Agreement.

     7.  Recapitalization.   If  as  a  result  of  any  (i)  reorganization  or
         ----------------
liquidation of the Company,  or (ii)  reclassification  of the Company's capital
stock,  or (iii)  consolidation  or merger of the Company  with or into  another
corporation,  or sale of all or  substantially  all the assets of the Company (a
reorganization  or  liquidation  of  the  Company  or  reclassification  of  the
Company's  capital  stock,  or a  merger,  consolidation  or  sale  of the  type
described in this subsection being a "Corporate  Transaction") while this Option
is outstanding,  the holders of the Common Stock become entitled to receive with
respect to their Common  Stock,  securities or assets other than, or in addition
to, their  Common  Stock,  upon  exercise of this Option the holder will receive
what the  holder  would  have  owned if the  holder  had  exercised  the  Option
immediately  before the first  Corporate  Transaction  which  occurred while the
Option was  outstanding  and had not  disposed of anything the holder would have
received as a result of that and all subsequent Corporate Transactions.

     8. Withholding  Taxes. If, whether because of a disposition of Common Stock
        ------------------
acquired on exercise of this Option,  or  otherwise,  the Company is required to
pay withholding  taxes to any Federal,  state or other taxing  authority and the
Employee  fails to  provide  the  Company  with the funds with which to pay that
withholding tax, the Company may withhold up to 50% of each payment of salary or
bonus to the  Employee  (which  will be in  addition  to any other  required  or
permitted

                                       -4-                      07/00
<PAGE>

withholding),  until the Company has been reimbursed for the entire  withholding
tax it was required to pay.

     9. Miscellaneous.
        -------------

          9.1 Except as provided  herein,  this  Agreement may not be amended or
otherwise modified unless evidenced in writing and signed by the Company and the
Employee.

          9.2 All notices under this Agreement shall,  unless otherwise provided
herein,  be mailed or  delivered  by hand to the  Company,  Attention  Corporate
Secretary,  or the Employee at their respective addresses set forth herein or at
such other  address as may be  designated in writing by either of the parties to
one another, and shall be effective upon actual receipt.

          9.3 This  Agreement has been entered into and shall be governed by and
construed in accordance with the laws of the State of New Jersey.

          9.4 This  Agreement  shall be  binding  upon and  inure to the  heirs,
successors and assigns of the Employee, subject, however, to the limitations set
forth in this Agreement with respect to assignment of this Agreement, the Option
or rights in either of them, and the successors and assigns of the Company.

                                          CYTOGEN CORPORATION

                                          By:
                                             ------------------------------
                                          An Officer of the Corporation

                                          ADDRESS: 600 College Road East-CN5308
                                                    Princeton, NJ  08540-5308

                                       -5-                      07/00OPTION TERM SHEET

Pursuant to the terms and conditions of your Offer of Employment  dated June 14,
2000,  you have been granted a  Non-Qualified  Stock Option to purchase  300,000
shares of CYTOGEN Common Stock as outlined below:

         Granted To:                Lawrence Hoffman
                                    SSN ###-##-####

         Grant Date:                July 10, 2000
         Options Granted:           300,000
         Option Price Per Share:    $10.141
         Expiration Date:           July 10, 2010
         Vesting Schedule:          33.3% per year for three years
                                    100,000 on 7/10/2001
                                    100,000 on 7/10/2002
                                    100,000 on 7/10/2003

By my signature below, I hereby acknowledge receipt of these Option terms, which
have been issued to me under the terms and  conditions of my Offer of Employment
dated June 14, 2000.

                                         Date:
-----------------------------                 ------------------------
Lawrence Hoffman
<PAGE>
                               CYTOGEN CORPORATION

                      NON-QUALIFIED STOCK OPTION AGREEMENT

     1. Grant of Option.  Subject to  all the  terms and  conditions  hereof and
        ---------------
the option term sheet attached hereto and made a part hereof (the "Term Sheet"),
the Company hereby grants to the Employee an option (the "Option"),  to purchase
shares of the Company's  Common Stock.  The Option is not intended to qualify as
an  Incentive  Stock  Option  within the meaning of Section 422A of the Internal
Revenue Code of 1986, as amended (the "Code"). In the event of any inconsistency
in the terms hereof and the terms of the Term Sheet, the terms of the Term Sheet
shall govern.

     2. Exercise of Option.
        ------------------

          2.1 Exercisability of Option.
              ------------------------

               2.1.1 Except as provided in Sections 2.1.2,  2.1.3, and 2.2, this
Option shall be exercisable only in accordance with the following schedule:

  Number of Years                           Percentage of Option Shares
Since Date of Grant                      Available for Purchase (Cumulative)
-------------------                      -----------------------------------

Less than one                                             0.0%
One but fewer than Two                                   33.3
Two but fewer than Three                                 66.6
Three or more                                           100.0

               2.1.2 If, prior to the Expiration Date, the Employee's employment
terminates  because of death or Total  Disability as defined below,  this Option
shall become  exercisable,  but only during the applicable  period  specified in
Section 2.4, in accordance with the following schedule:

  Number of Years                           Percentage of Option Shares
Since Date of Grant                      Available for Purchase (Cumulative)
-------------------                      -----------------------------------

Less than one                                              50%
One but fewer than Two                                     50

               2.1.2 (a) The term "Total  Disability"  as used in this Agreement
shall  mean  inability  of an  Employee  to  engage in any  substantial  gainful
activity by reason of a  medically  determinable  physical or mental  impairment
which can be  expected to result in death or which has lasted or can be expected
to last for a continuous period of not less than 12 months.  All  determinations
as to the date and  extent  of  disability  of an  Employee  will be made by the
Committee.

               2.1.3 (a) Upon the occurrence of a Major Event, as defined below,
in addition to those shares  available  for purchase as of the date of the Major
Event all of the  remaining  Option  Shares  not then  otherwise  available  for
purchase as of such date shall become immediately available for purchase.

                     (b) (i) The  term  "Major  Event" as used in this Agreement
shall mean (1) the Company  enters  into one or more  definitive  agreements  to
merge or consolidate the Company with or into another corporation, or to sell or
otherwise  dispose of all or substantially  all of the Company's  assets,  or to
effect any other
                                                                07/00
<PAGE>

transaction,  consolidation or reorganization  having similar results or effect;
(2) any person other than the Company makes a tender or exchange  offer for more
than 50% of Common  Stock  pursuant to which  purchases  of any amount of Common
Stock are made; (3) stock  representing more than 50% of the voting power of the
Company  is  acquired  by any person  other than the  Company in any one or more
transaction(s);  or (4) within any 24-month  period  persons who were members of
the Company's  Board of Directors  immediately  prior to such  24-month  period,
together  with any  persons  who were first  elected as  directors  during  such
24-month  period  by or upon  the  recommendation  of  members  of the  Board of
Directors who were members  immediately  prior to such  24-month  period and who
constituted  a majority of the Board of Directors at the time of such  election,
cease to constitute a majority of the Board of Directors.

          2.2  Expiration  Date.  This  Option  may not be  exercised  after the
               ----------------
Expiration Date.

          2.3 Continuous  Employment Required.  This Option may not be exercised
              -------------------------------
unless on the date of exercise  (i) the Employee  has been  continuously  in the
employment of the Company since the Date of Grant or (ii) the Employee meets the
requirements  of  Section  2.4.  For  the  purposes  of  this   Agreement,   (i)
"employment"  shall have the  meaning  specified  in Section  1.421-7(h)  of the
Income Tax Regulations or any successor regulations,  and (ii) if this Agreement
shall be assumed or a new option agreement substituted therefor in a transaction
to  which  Section  425(a)  of the  Code  or any  successor  provision  applies,
employment by the assuming or substituting  corporation  shall be considered for
all purposes of this Agreement to be employment by the Company.  For purposes of
this Agreement, any leave of absence taken with the consent of the Company for a
period not greater than 90 days shall not be deemed an interruption of otherwise
continuous  employment so long as the  Employee's  right to employment  with the
Company or any Related  Corporation is guaranteed by contract through the period
of leave. If the period of leave exceeds 90 days, and if the Employee's right to
employment  is not  guaranteed  by  contract  through  the period of leave,  the
employment will be deemed terminated as of the first day of the leave.

          2.4 Exercise After Termination of Employment.
              ----------------------------------------

               2.4.1 If the  Employee  ceases to be  employed by the Company for
any reason other than death or Total  Disability,  and provided that through the
date of termination of employment the Employee shall have been  continuously  in
the  employment  of the Company  since the Date of Grant,  the right to exercise
this Option  shall  terminate  three  months  after the date of  termination  of
employment,  but in no event after the Expiration Date.  During that three-month
period, this Option may be exercised only in respect of any or all Option Shares
which were  available for purchase at the date of  termination  of employment as
provided in Section 2.1.1.

               2.4.2 If the  Employee  ceases to be  employed  because  of Total
Disability,  and provided that through the date of termination of employment the
Employee shall have been continuously in the employment of the Company since the
Date of Grant,  the right to exercise this Option shall terminate one year after
the date of  termination  of  employment,  but in no event after the  Expiration
Date.  During  that  one-year  period,  this Option may be  exercised  only with
respect to any

                                       -2-                      07/00
<PAGE>

or  all  Option  Shares  which  were  available  for  purchase  on the  date  of
termination of employment as provided in Section 2.1.2.

               2.4.3 If the  Employee  ceases to be employed by reason of his or
her death,  or dies  following the date of his or her  termination of employment
but at a time when this Option still would be  exercisable  but for the death of
the Employee,  the Option may be exercised by the person or persons to whom this
Option  passed by will or by the laws of  descent  and  distribution  (but by no
other  persons)  until  the  earlier  of (i)  the  end of  the  one-year  period
immediately  following the date of death,  (ii) the Expiration  Date or (iii) if
the death occurs after the  termination of employment,  the end of the period in
which this Option could be exercised under Section 2.4.1 or 2.4.2.

     3. Exercise.
        --------

          3.1 Manner of Exercise.  Subject to the  conditions  set forth in this
              ------------------
Agreement, this Option may be exercised in whole or in part at any time, or from
time to time,  during its term. To exercise this Option,  the Employee (or other
person  entitled to exercise  this Option)  must deliver to the Company,  at its
principal office:

                    (i) a notice of exercise of this  Option,  which  states the
          extent to which this Option is being exercised;

                    (ii) a certified or bank cashier's  check in an amount equal
          to the Exercise  Price of this Option times the number of shares as to
          which it is being  exercised,  or  consideration in such other form as
          may be permitted under the terms on which this Option is granted; and

                    (iii) a  certified  or bank  cashier's  check  equal  to any
          withholding  taxes the  Company  is  required  to pay  because  of the
          exercise of this Option.

The  date on  which  the  Company  receives  all  the  items  specified  in this
subsection  will be the date on which  this  Option is  exercised  to the extent
described in the notice of election.

          3.2 Laws and  Regulations.  The  obligation of the Company to sell and
              ---------------------
deliver  shares of Common  Stock  under  this  Agreement  will be subject to the
condition  that legal  counsel  for the Company be  satisfied  that the sale and
delivery will not violate the Securities  Act of 1933, as amended,  or any other
applicable laws, rules or regulations.

          3.3 Delivery of Stock  Certificates.  As promptly as practicable after
              -------------------------------
this Option is  exercised,  the Company will deliver to the person who exercises
this Option  certificates,  registered in that person's name,  representing  the
number of shares of Common  Stock which were  purchased  by the exercise of this
Option. Each certificate may bear a legend to indicate, if applicable,  that (i)
the Common Stock  represented  by the  certificate  was issued in a  transaction
which was not registered  under the Securities Act of 1933, as amended,  and may
only be sold or transferred in a transaction  which is registered under that Act
or is exempt from the registration requirements of that Act, and (ii) the Common
Stock  represented by the certificate is subject to the obligation of the holder
to pay any unpaid balance of the Exercise

                                       -3-                      07/00
<PAGE>

Price  (whether  pursuant to a promissory  note or  otherwise),  and/or that the
Common Stock is pledged to secure such an obligation.

     4.  Nontransferability of Options.  Except as otherwise expressly provided,
         -----------------------------
this Option may be  exercised  only by the  Employee  or his or her  guardian or
legal  representative  during the  Employee's  lifetime.  This Option may not be
assigned,  pledged or hypothecated in any way, will not be subject to execution,
and will not be  transferable  otherwise than by will or the laws of descent and
distribution.  The Company will not recognize  any attempt to assign,  transfer,
pledge,  hypothecate  or  otherwise  dispose  of  this  Option  contrary  to the
provisions of this  Agreement,  or any levy of any attachment or similar process
upon any Option, and, except as expressly stated herein, the Company will not be
required  to, and will not,  issue  Common  Stock on  exercise of this Option to
anyone who claims to have  acquired this Option from the Employee to whom it was
granted.

     5. No Employment  Rights or Other Employee  Benefits.  Nothing contained in
        ------------------------------------------------
this   Agreement   shall  be  construed  or  deemed  by  any  person  under  any
circumstances to bind the Company to continue the employment of the Employee for
the period within which this Option may be exercised. The amount of any economic
benefit  directly  or  indirectly  realized  by the  Employee as a result of the
exercise of this Option or the sale of shares  received upon such exercise shall
not constitute  "compensation" with respect to which any other employee benefits
of the Employee are determined,  including,  without limitation,  benefits under
any defined  benefit,  defined  contribution,  profit  sharing,  life insurance,
salary contribution or other benefit plans.

     6. Rights as a Stockholder.  Except as otherwise expressly provided in this
        -----------------------
Agreement,  the Employee  shall have no rights as a stockholder  with respect to
any Option  Shares,  unless and until those shares are  purchased in  accordance
with this Agreement.

     7.  Recapitalization.   If  as  a  result  of  any  (i)  reorganization  or
         ----------------
liquidation of the Company,  or (ii)  reclassification  of the Company's capital
stock,  or (iii)  consolidation  or merger of the Company  with or into  another
corporation,  or sale of all or  substantially  all the assets of the Company (a
reorganization  or  liquidation  of  the  Company  or  reclassification  of  the
Company's  capital  stock,  or a  merger,  consolidation  or  sale  of the  type
described in this subsection being a "Corporate  Transaction") while this Option
is outstanding,  the holders of the Common Stock become entitled to receive with
respect to their Common  Stock,  securities or assets other than, or in addition
to, their  Common  Stock,  upon  exercise of this Option the holder will receive
what the  holder  would  have  owned if the  holder  had  exercised  the  Option
immediately  before the first  Corporate  Transaction  which  occurred while the
Option was  outstanding  and had not  disposed of anything the holder would have
received as a result of that and all subsequent Corporate Transactions.

     8. Withholding  Taxes. If, whether because of a disposition of Common Stock
        ------------------
acquired on exercise of this Option,  or  otherwise,  the Company is required to
pay withholding  taxes to any Federal,  state or other taxing  authority and the
Employee  fails to  provide  the  Company  with the funds with which to pay that
withholding tax, the Company may withhold up to 50% of each payment of salary or
bonus to the  Employee  (which  will be in  addition  to any other  required  or
permitted

                                       -4-                      07/00
<PAGE>

withholding),  until the Company has been reimbursed for the entire  withholding
tax it was required to pay.

     9. Miscellaneous.
        -------------

          9.1 Except as provided  herein,  this  Agreement may not be amended or
otherwise modified unless evidenced in writing and signed by the Company and the
Employee.

          9.2 All notices under this Agreement shall,  unless otherwise provided
herein,  be mailed or  delivered  by hand to the  Company,  Attention  Corporate
Secretary,  or the Employee at their respective addresses set forth herein or at
such other  address as may be  designated in writing by either of the parties to
one another, and shall be effective upon actual receipt.

          9.3 This  Agreement has been entered into and shall be governed by and
construed in accordance with the laws of the State of New Jersey.

          9.4 This  Agreement  shall be  binding  upon and  inure to the  heirs,
successors and assigns of the Employee, subject, however, to the limitations set
forth in this Agreement with respect to assignment of this Agreement, the Option
or rights in either of them, and the successors and assigns of the Company.

                                          CYTOGEN CORPORATION

                                          By:
                                             ------------------------------
                                          An Officer of the Corporation

                                          ADDRESS: 600 College Road East-CN5308
                                                    Princeton, NJ  08540-5308

                                       -5-                      07/00

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