Document:

Exhibit 10.1

 

	CONFIDENTIAL	EXECUTION VERSION

 

AMENDMENT No. 2 to LICENSE AGREEMENT

 

This AMENDMENT NO. 2
to LICENSE AGREEMENT (this “Amendment No. 2”) is made and entered into effective as of May 11, 2015 (the “Amendment
No. 2 Effective Date”), by and between Mirna Therapeutics, Inc., a Delaware corporation with offices at 2150 Woodward
Street, Suite 100, Austin, Texas 78744 (“MirnaRx”), and Marina Biotech, Inc., a Delaware corporation with offices
c/o Pryor Cashman LLP, 7 Times Square, New York, New York 10036 (“Marina Bio”).

 

WHEREAS, MirnaRx
and Marina Bio are parties to a License Agreement dated December 22, 2011, as amended by the Letter Amendment dated November 16,
2012, and Amendment No. 1, dated December 27, 2013 (“Amendment No. 1”) and as further supplemented by
that certain Amendment Side Letter referred to in Amendment No.1, dated January 9, 2014 (collectively, the “License Agreement”);

 

WHEREAS, pursuant
to the License Agreement, Marina Bio granted to MirnaRx a license under Marina’ Bio’s technology and intellectual property
rights relating to Marina Bio’s liposomal delivery technology known as NOV340 (the “Marina Technology”),
to develop and commercialize drug products incorporating such Marina Technology in combination with MirnaRx’s proprietary
compound miR-34, and other specified compounds selected by MirnaRX pursuant to the terms of the License Agreement; and

 

WHEREAS, MirnaRx
and Marina Bio desire to amend the License Agreement to modify the consideration payable by MirnaRx to Marina Bio with respect
to development of products containing miR-34 and using the Marina Technology.

 

NOW THEREFORE,
in consideration of the foregoing premises, the mutual promises and covenants of the Parties hereinafter set forth, and other good
and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Parties, intending to be legally
bound, do hereby agree as follows.

 

1.1.        Amendment
of License Agreement.   In accordance with Section 12.1 of the License Agreement, the Parties hereby agree to amend the License
Agreement, effective as of the Amendment No. 2 Effective Date, in accordance with the remainder of this Section 1. Capitalized
terms not defined in this Amendment No. 2 shall have the meaning given to those terms in the License Agreement. With the exception
of those sections of the License Agreement that are expressly amended by this Amendment No. 2, the remainder of the License Agreement
as in effect prior to the date hereof shall remain in full force and effect as provided therein.

 

1.2.        Section
5.3(c) (as amended by Amendment No. 1) shall be amended and restated in its entirety with the following:

 

5.3(c) Notwithstanding
Sections 5.3(a) and 5.3(b) and the milestone table above, and solely with respect to Licensed Products containing or incorporating
miR-34:

 

    	 

    	 

    

 

(i) no Milestone Payment
shall be payable by MirnaRx for (A) achievement of the Milestone Event in clause (i)(3) of the milestone table above, or (B) any
Additional Indications pursuant to clause (ii)(1) of the milestone table above; and

 

(ii) with respect to the
Milestone Payment payable to Marina Bio upon the date the first patient is dosed in the first Phase 2 trial for such Licensed Product
pursuant to clause (i)(2) of the milestone table above, MirnaRx may elect to pre-pay such Milestone Payment to Marina Bio prior
to the achievement of such Milestone Event (the “miR-34 Prepayment”), and if such miR-34 Prepayment is made
to Marina Bio on or before May 13, 2015 (the “Prepayment Date”), such Milestone Payment shall be reduced
to $400,000. Marina Bio agrees that if the miR-34 Prepayment is made on or before the Prepayment Date, such payment shall constitute
full and complete satisfaction of the Milestone Payment due under clause (i)(2) of the milestone table.

 

For clarity, Sections 5.3(a)
and 5.3(b) and the milestone table shall apply in full to all Licensed Products other than any Licensed Product containing or incorporating
miR-34, unless the Parties mutually agree otherwise in writing.

 

1.3.     No
Other Amendments.   Except as specifically modified herein, the remaining terms of the License Agreement shall remain in full
force and effect.

 

1.4.     Prepayment.   MirnaRx hereby agrees to pay to Marina Bio, within five (5) business days after the Amendment No. 2 Effective Date, an amount equal
to Four Hundred Thousand Dollars ($400,000), representing full satisfaction of the Milestone Payment due under Section 5.3(a)(i)(2)
of the License Agreement for a Licensed Product containing the Selected MirnaRx Compound miR-34, in accordance with Section 5.3(c)
of the License Agreement, as amended by this Amendment No. 2.

 

1.5.     Counterparts;
Facsimile Execution.   This Amendment No. 2 may be executed in two (2) or more counterparts, each of which shall be deemed an
original, but all of which together shall constitute one and the same instrument. This Amendment No. 2 may be executed by facsimile
signatures and such signatures shall be deemed to bind each Party as if they were original signatures.

 

[Signature Page Follows]

 

    	 

    	 

    

 

     IN
WITNESS WHEREOF, the Parties have caused this Amendment No. 2 to be executed by their respective officers thereunto duly authorized
as of the Amendment Effective Date.

  

	Mirna Therapeutics, Inc.	 	Marina Biotech, Inc.
	 	 	 	 	 
	Signature : 	/s/ Dr. Paul Lammers	 	Signature : 	/s/ J. Michael French
	 	 	 	 	 
	Name : 	Dr. Paul Lammers	 	Name : 	J. Michael French
	 	 	 	 	 
	Title : 	President & CEO	 	Title : 	President & CEO

 

[Signature
page to Amendment No. 2 to License Agreement]Exhibit 10.1

 

Fifth Supplemental Agreement to Loan
Agreement

 

Agreement Number: BR2011021-013

 

	Party A (Creditor):	Bairui Trust Co., Ltd.
	Legal Representative:	Baojun MA
	Address:	ZhongyuanGuangfa Development Financial Building, No. 10 Business Waihuan Road, Zhengdong New District, Zhengzhou
	Contact Address:	ZhongyuanGuangfa Development Financial Building, No. 10 Business Waihuan Road, Zhengdong New District, Zhengzhou
	Telephone:	0371-69177223         Fax:           0371-69177300
	 	 
	Party B (Debtor):	Henan Pingdingshan Hongli Coking and Coal Co., Ltd.
	Legal Representative:	Jianhua LV
	Address:	The intersection between Kuanggong Road and Tiyu Road ,Xinhua District, Pingdingshan
	Contact Address:	The intersection between Kuanggong Road and Tiyu Road ,Xinhua District, Pingdingshan
	Telephone:	0375-2912016           Fax:           0375-2920035
	 	 
	Party C (Guarantor):	Pingdingshan Hongyuan Energy Science and Technology Development, Co., Ltd.
	Legal Representative:	Jianhua LV
	Address:	West Renmin Road, Chengguan Town, Baofeng County, Pingdingshan, Henan Province, People’s Republic of China
	Contact Address:	West Renmin Road, Chengguan Town, Baofeng County, Pingdingshan, Henan Province, People’s Republic of China
	Telephone:	0375-2912016           Fax:          0375-2920035
	 	 
	Party D (Guarantor):	Jianhua LV
	Identification Number:	410403196711232014
	Address:	Kaiyuan South Road East Yard No. 2, Building No. 3, No.134, Zhanhe District, Pingdingshan, Henan Province
	Contact address:	Kaiyuan South Road East Yard No. 2, Building No. 3, No.134, Zhanhe District, Pingdingshan, Henan Province
	Telephone:	13903750608             Fax:          0375-2920035

 

In view of:

 

	 	1.	Pursuant to request from Pingdingshan Rural Agricultural Trust Cooperative (hereinafter “Trustee”), Party A established Barui Baoying No. 117 Capital Trust (Hongli Coke), and disbursed funds from such trust to Party B in the form of loans.

 

	 	2.	Party A, Party B, Party C and Party D entered into the following agreements: Loan Agreement (Agreement Number: BR2011021-002, the “Loan Agreement”) on April 2, 2011; Supplemental Agreement to Loan Agreement (Agreement Number: BR2011021-005, the “First Supplemental Agreement”) on November 30, 2011; Second Supplemental Agreement to Loan Agreement (Agreement Number: BR2011021-008, the “Second Supplemental Agreement”) on April 23, 2013; Third Supplemental Agreement to Loan Agreement (Agreement Number: BR2011021-011, the “Third Supplemental Agreement”) on April 2, 2014; and Fourth Supplemental Agreement to Loan Agreement (Agreement Number: BR2011021-012, the “Fourth Supplemental Agreement”) on April 3, 2014. The Agreement set the terms that Party A will disburse trust loan to Party B, while Party C and Party D will be the guarantors of the loan. The Loan Agreement, the First Supplemental Agreement, the Second Supplemental Agreement, the Third Supplemental Agreement, and the Fourth Supplemental Agreement are collectively referred to as the “Original Agreement.”

 

    	 

    	 

    

 

	 	3.	As agreed by Trustee, Party B has applied with Party A for payment extension, which extension Party A is processing in accordance with the application.

 

Now, Party A, Party B, Party C and Party
D, after negotiations, mutually enter into this agreement to amend the terms of the Original Agreement.

 

	 	1.	The Amended Terms

 

	 	a.	The parties hereby agree that the loan principal of RMB 78,000,000.00 originally due on April 2, 2015 is now due on April 2, 2016.

 

	 	b.	The applicable interest rate for the loan principal outstanding commencing as of the date hereof shall be 11.88% per year.

  

	 	c.	The interest rate (based on 11.88% per year) is calculated on a daily basis (based on 365 days per year) from the actual date that Party A issues a loan. Interest payment is settled on the 20th day of the final month of each calendar quarter. Principal is due on the last interest payment date, with all outstanding interest due along with the principal. If settlement date falls on legal or public holiday, then settlement date shall be the first working day thereafter. Interest payment shall be made into an account designated by Party A.

 

	 	2.	Notice and Delivery

 

Any notice or response relating
to this agreement shall be by personal delivery, certified mail, express mail or facsimile. The following shall constitute delivery:

 

	 	a.	If by personal delivery, the date such delivery is signed for by the intended recipient;

 

	 	b.	If by certified mail, on the fifth working day after mailing date;

 

	 	c.	If by express mail, on the third working day after mailing date;

 

	 	d.	If by facsimile, on the date of transmission.

 

All notices under this agreement
shall be made in accordance with the contact information set forth at the beginning of this agreement. Each of Debtor and Guarantors
must notify Creditor in writing at least 15 days in advance of any change to its contact information, and shall be solely responsible
for any legal liabilities resulting from ineffective notice due to noncompliance with this provision.

 

	 	3.	Others

 

	 	a.	This agreement shall supplement the Loan Agreement, and this agreement shall govern if there is any inconsistency with the Loan Agreement, the First Supplemental Agreement, the Second Supplemental Agreement, the Third Supplemental Agreement or the Fourth Supplemental Agreement, provided that any terms not covered by this agreement shall be governed by the Loan Agreement, the First Supplemental Agreement, the Second Supplemental Agreement, the Third Supplemental Agreement, and the Fourth Supplemental Agreement.

 

	 	b.	This agreement shall become effective after its signing by the legal representatives or other authorized representatives of Parties A, B, C and D (or their seals).

 

	 	c.	This agreement shall be made in six copies, with Parties A and B each holding two, and Parties C and D each holding one, all having the same legal effect.

 

    	 

    	 

    

 

Signature Page of Agreement BR2011021-013

 

	Party A (Creditor):	Bairui Trust Co., Ltd. [seal]
	 	 
	Legal representative or	 
	Authorized Representative:	 /s/ Baojun MA
	 	 
	Party B (Debtor):	Pingdingshan Hongli Coal and Coking Co., Ltd. [seal]
	 	 
	Legal representative or	 
	Authorized Representative:	/s/  Jianhua LV
	 	 
	Party C (Guarantor):	Pingdingshan Hongyuan Energy Science and Technology Development Co., Ltd. [seal]
	 	 
	Legal representative	 
	or Authorized Representative:	/s/ Jianhua LV
	 	 
	Party D (Guarantor):	/s/ Jianhua LV

 

The agreement is entered into in Zhengdong New District,
Zhengzhou, Henan Province, on April 3, 2015

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