Document:

exv10w1

 

Exhibit 10.1 

SECURITIES PURCHASE AGREEMENT

     This Securities Purchase Agreement (this “Agreement”) is dated as of September 11,
2007, between Carrizo Oil & Gas, Inc., a Texas corporation (the “Company”), and the
purchaser identified on the signature page hereto (the “Purchaser”).

     WHEREAS, subject to the terms and conditions set forth in this Agreement, the Company desires
to issue and sell to the Purchaser, and the Purchaser desires to purchase from the Company, shares
of Common Stock (as defined herein) as set forth herein on the Closing Date (as defined herein)
pursuant to an effective Registration Statement on Form S-3, Commission File No. 333-142346.

     NOW, THEREFORE, IN CONSIDERATION of the mutual covenants contained in this Agreement, and for
other good and valuable consideration the receipt and adequacy of which are hereby acknowledged,
the Company and the Purchaser agree as follows:

ARTICLE I.

DEFINITIONS

     1.1 Definitions. In addition to the terms defined elsewhere in this Agreement, for all
purposes of this Agreement, the following terms have the meanings indicated in this Section 1.1:

     “Action” means any action, suit, inquiry, notice of violation, proceeding
(including any partial proceeding such as a deposition) or investigation pending or
threatened in writing against or affecting the Company, any Subsidiary or any of their
respective properties before or by any court, arbitrator, governmental or administrative
agency, regulatory authority (federal, state, county, local or foreign), stock market, stock
exchange or trading facility.

     “Affiliate” means any Person that, directly or indirectly through one or more
intermediaries, controls or is controlled by or is under common control with a Person, as
such terms are used in and construed under Rule 144. With respect to a Purchaser, any
investment fund or managed account that is managed on a discretionary basis by the same
investment manager as such Purchaser will be deemed to be an Affiliate of such Purchaser.

     “Business Day” means any day except Saturday, Sunday and any day that is a
federal legal holiday or a day on which banking institutions in the State of New York are
authorized or required by law or other governmental action to close.

     “Closing” means the closing of the purchase and sale of the Shares pursuant to
Section 2.1.

     “Closing Date” means the third (3rd) Trading Day following the date
of this Agreement.

     “Commission” means the United States Securities and Exchange Commission.

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     “Common Stock” means the common stock of the Company, par value $.01 per share,
and any securities into which such common stock may hereafter be reclassified.

     “Common Stock Equivalents” means any securities of the Company which would
entitle the holder thereof to acquire at any time Common Stock, including, without
limitation, any debt, preferred stock, rights, options, warrants or other instrument that is
at any time convertible into or exercisable or exchangeable for, or otherwise entitles the
holder thereof to receive, Common Stock.

     “Company Counsel” means Baker Botts L.L.P.

     “Disclosure Documents” means the Registration Statement, the SEC Reports and
the Schedules, considered together.

     “Exchange Act” means the Securities Exchange Act of 1934, as amended.

     “GAAP” shall have the meaning ascribed to such term in Section 3.1(f).

     “Lien” means a lien, charge, security interest, encumbrance, right of first
refusal, preemptive right or other restriction.

     “Material Adverse Effect” means any of (a) a material and adverse effect on the
legality, validity or enforceability of any Transaction Document, (b) a material and adverse
effect on the results of operations, assets, business or condition (financial or otherwise)
of the Company and the Subsidiaries, taken as a whole, or (c) a material and adverse
impairment to the Company’s ability to perform, on a timely basis, its obligations under any
Transaction Document.

     “Material Permits” means all certificates, authorizations and permits issued by
the appropriate federal, state, local or foreign regulatory authorities necessary for the
Company and its Subsidiaries to conduct their respective businesses as described in the
Disclosure Documents.

     “Per Share
Purchase Price” equals $41.40, subject to adjustment for reverse
and forward stock splits, stock dividends, stock combinations and other similar transactions
of the Common Stock that occur after the date of this Agreement and prior to the Closing.

     “Person” means an individual or corporation, partnership, trust, incorporated
or unincorporated association, joint venture, limited liability company, joint stock
company, government (or an agency or subdivision thereof) or other entity of any kind.

     “Prospectus Supplement” means the supplement to the base prospectus contained
in the Registration Statement and filed or to be filed with the Commission pursuant to Rule
424(b) promulgated under the Securities Act.

     “RBC” means RBC Capital Markets Corporation.

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     “Registration Statement” means the registration statement on Form S-3 of the
Company, (Commission File No. 333-142346) covering the sale by the Company to the Purchaser
of the Shares, including the Prospectus Supplement, amendments and supplements to such
registration statements or Prospectus Supplement, including pre- and post-effective
amendments, all exhibits thereto, and all material incorporated by reference or deemed to be
incorporated by reference in such registration statements.

     “Regulation S-X” means Regulation S-X promulgated by the Commission pursuant to
the Exchange Act.

     “Required Approvals” means (i) filings required pursuant to Section 4.1 and
Section 4.4, (ii) filings required in connection with the issuance and listing on The Nasdaq
Global Select Market of the Shares, (iii) such filings as are required to be made under
applicable state securities laws and (iv) those that have been obtained prior to the date of
this Agreement.

     “Rule 144” means Rule 144 promulgated by the Commission pursuant to the
Securities Act, as such rule may be amended from time to time, or any similar rule or
regulation hereafter adopted by the Commission having substantially the same effect as such
rule.

     “Schedules” means the disclosure schedules prepared by the Company and attached
to this Agreement.

     “SEC Reports” shall have the meaning ascribed to such term in Section 3.1(f).

     “Securities Act” means the Securities Act of 1933, as amended.

     “Shares” means the shares of Common Stock issued or issuable to the Purchaser
pursuant to this Agreement.

     “Short Sale” means all “short sales” as defined in Rule 200 of Regulation SHO
promulgated under the Exchange Act.

     “Subscription Amount” means, as to the Purchaser, the amount set forth below
the Purchaser’s signature block on the signature page hereto, in United States dollars and
in immediately available funds.

     “Subsidiary” means any “significant subsidiary” as defined in Rule 1-02(w) of
Regulation S-X promulgated by the Commission under the Exchange Act.

     “Trading Day” means (i) a day on which the Common Stock is traded on a Trading
Market (other than the OTC Bulletin Board), or (ii) if the Common Stock is not listed on a
Trading Market (other than the OTC Bulletin Board), a day on which the Common Stock is
traded in the over-the-counter market, as reported by the OTC Bulletin Board, or (iii) if
the Common Stock is not quoted on the OTC Bulletin Board, a day on which the Common Stock is quoted in the over-the-counter market as reported by the
National Quotation Bureau Incorporated (or any similar organization or agency

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succeeding to
its functions of reporting prices); provided that in the event that the Common Stock
is not listed or quoted as set forth in (i), (ii) and (iii) hereof, then Trading Day shall
mean a Business Day.

     “Trading Market” means whichever of the New York Stock Exchange, the American
Stock Exchange, The NASDAQ Stock Market or the OTC Bulletin Board on which the Common Stock
is listed or quoted for trading on the date in question.

     “Transaction Documents” means this Agreement and any other agreements executed
or delivered by the Company in connection with the transactions contemplated hereunder.

     “Transfer Agent” means American Stock Transfer & Trust Company.

ARTICLE II.

PURCHASE AND SALE

     2.1 Closing. On the Closing Date, the Purchaser shall purchase from the Company and
the Company shall issue and sell to the Purchaser, a number of Shares equal to the Purchaser’s
Subscription Amount divided by the Per Share Purchase Price. Upon satisfaction of the conditions
set forth in Section 2.3, the Closing shall occur telephonically or at such location as the parties
shall mutually agree.

     2.2 Deliveries.

     (a) On the Closing Date, the Company shall:

     (i) deliver or cause to be delivered the number of Shares equal to the
Purchaser’s Subscription Amount divided by the Per Share Purchase Price, by
electronic book-entry at The Depository Trust Company (“DTC”), registered in the
Purchaser’s name and address as set forth on the Purchaser’s signature page hereto,
and released by the Transfer Agent, to the Purchaser at the Closing. No later than
one (1) Business Day after the execution of this Agreement by the Purchaser and the
Company, the Purchaser shall: (I) direct the broker-dealer at which the account or
accounts to be credited with the Shares are maintained, which broker-dealer shall be
a DTC participant, to set up a Deposit/Withdrawal at Custodian (“DWAC”) instructing
the Transfer Agent to credit such account or accounts with the Shares by means of an
electronic book entry delivery, and (II) remit by wire transfer the amount of funds
equal to the aggregate purchase price for the Shares being purchased by the
Purchaser to the following account:

Carrizo Oil & Gas, Inc.

                                        

ABA#                            

Acct#                         ; or

It is the Purchaser’s responsibility to (A) make the necessary wire transfer in a
timely manner and (B) arrange for settlement by way of DWAC in a timely

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manner. If
the Purchaser does not deliver the aggregate purchase price for the Shares or does
not make proper arrangements for settlement in a timely manner, the Shares may not
be delivered at Closing to the Purchaser or the Purchaser may be excluded from the
Closing altogether;

     (ii) deliver or cause to be delivered to the Purchaser any prospectus and
Prospectus Supplement as required under the Securities Act; and

     (iii) deliver or cause to be delivered to the Purchaser a legal opinion of
Company Counsel, in the form of Exhibit A attached hereto, addressed to the
Purchaser and providing that RBC and the Purchaser are entitled to rely thereon.
Without limiting the generality of Section 2.3(b), the Purchaser’s obligation to
fund on the Closing Date shall be conditioned upon satisfaction of the conditions in
Section 2.3(b), including delivery of any receivables by the Company.

     (b) On the Closing Date, the Purchaser shall deliver or cause to be delivered to the
Company the Purchaser’s Subscription Amount by remitting by wire transfer the amount of
funds equal to the aggregate purchase price for the Shares being purchased by the Purchaser
to an account designated by the Company.

     2.3 Closing Conditions.

     (a) The obligations of the Company hereunder in connection with the Closing are subject
to the following conditions being met:

     (i) all representations and warranties of the Purchaser contained herein were
true and correct on the date hereof and remain true and correct as of the Closing
Date, except that those representations and warranties that address matters only as
of a particular date shall remain true and correct as of such date;

     (ii) all obligations, covenants and agreements of the Purchaser required to be
performed at or prior to the Closing Date shall have been performed;

     (iii) the Purchaser shall have delivered the Subscription Amount in accordance
with Section 2.2(b) of this Agreement; and

     (iv) the transactions contemplated in each of those other Securities Purchase
Agreements between the Company and the purchasers named therein, each dated the date
hereof and each containing terms and conditions substantially similar to the terms
and conditions hereof, shall be consummated prior to, simultaneous with or
immediately following the transactions contemplated hereby.

     (b) The obligations of the Purchaser hereunder in connection with the Closing are
subject to the following conditions being met or waived in writing by the Purchaser:

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     (i) all representations and warranties of the Company contained herein were
true and correct on the date hereof and remain true and correct as of the Closing
Date, except that those representations and warranties that address matters only as
of a particular date shall remain true and correct as of such date;

     (ii) all obligations, covenants and agreements of the Company required to be
performed at or prior to the Closing Date shall have been performed;

     (iii) the Company shall have delivered the items set forth in Section 2.2(a) of
this Agreement;

     (iv) there shall have been no Material Adverse Effect with respect to the
Company since the date hereof;

     (v) the Prospectus Supplement shall have been filed with the Commission and the
Registration Statement shall be effective and available for the issuance and sale of
the Shares hereunder;

     (vi) RBC shall have received signed letters from Pannell Kerr Forster of Texas,
P.C. (“PKF”) addressed to RBC and the Board of Directors of the Company confirming
that they are an independent registered public accounting firm within the meaning of
the Securities Act and the rules and regulations promulgated thereunder (the
“Rules”) and containing such other statements and information as is ordinarily
included in accountants’ “comfort letters” with respect to the financial statements
and certain financial and statistical information contained in the Registration
Statement and the Prospectus Supplement;

     (vii) no order preventing or suspending the use of any prospectus or the
Prospectus Supplement shall have been or shall be in effect and no order suspending
the effectiveness of the Registration Statement shall be in effect and no
proceedings for such purpose shall be pending before or threatened by the
Commission, and any requests for additional information on the part of the
Commission (to be included in the Registration Statement or the prospectus or the
Prospectus Supplement or otherwise) shall have been complied with to the
satisfaction of the Commission and the Purchaser; and

     (viii) from the date hereof to the Closing Date, trading in the Common Stock
shall not have been suspended by the Commission and, at any time prior to the
Closing Date, trading in securities generally as reported by Bloomberg Financial
Markets shall not have been suspended or limited, or minimum prices shall not have
been established on securities whose trades are reported by such service, nor shall
a banking moratorium have been declared either by the United States or New York
state authorities nor shall there have occurred any material outbreak or escalation
of hostilities involving the United States of America which,
in each case, in the reasonable judgment of the Purchaser, makes it
impracticable to purchase the Shares at the Closing.

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ARTICLE III.

REPRESENTATIONS AND WARRANTIES

     3.1 Representations and Warranties of the Company. The Company represents and
warrants to each Purchaser, except as disclosed or incorporated by reference in the Registration
Statement, as follows:

     (a) Organization and Qualification. The Company and each Subsidiary is an
entity duly incorporated or otherwise organized, validly existing and in good standing under
the laws of the jurisdiction of its incorporation or organization (as applicable), with the
requisite power and authority to own and use its properties and assets and to carry on its
business as currently conducted. Neither the Company nor any Subsidiary is in violation of
any of the provisions of its respective certificate or articles of incorporation, bylaws or
other organizational, charter or equivalent documents. The Company and each Subsidiary is
duly qualified to conduct business and is in good standing as a foreign corporation or other
entity in each jurisdiction in which the nature of the business conducted or property owned
by it makes such qualification necessary, except where the failure to be so qualified or in
good standing, as the case may be, could not, individually or in the aggregate, have or
reasonably be expected to have a Material Adverse Effect.

     (b) Authorization; Enforcement. The Company has the requisite corporate power
and authority to enter into and to consummate the transactions contemplated by each of the
Transaction Documents and otherwise to carry out its obligations hereunder and thereunder.
The execution and delivery of each of the Transaction Documents by the Company and the
consummation by it of the transactions contemplated hereby and thereby have been duly
authorized by all necessary action on the part of the Company and no further action is
required by the Company, its board of directors or shareholders in connection herewith and
therewith other than in connection with the Required Approvals. Each Transaction Document
has been (or upon delivery will have been) duly executed by the Company and, when delivered
in accordance with the terms hereof, will constitute the valid and binding obligation of the
Company, enforceable against the Company in accordance with its terms, except (i) as limited
by applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general
application affecting enforcement of creditors’ rights generally and (ii) as limited by laws
relating to the availability of specific performance, injunctive relief or other equitable
remedies.

     (c) No Conflicts. The execution, delivery and performance of the Transaction
Documents by the Company and the consummation by the Company of the transactions
contemplated thereby do not and will not (i) conflict with or violate any provision of the
Company’s or any Subsidiary’s certificate or articles of incorporation, bylaws or other
organizational, charter or equivalent documents, or (ii) conflict with, or constitute a
default (or an event that with notice or lapse of time or both would become a default)
under, or give to others any rights of termination, amendment, acceleration or cancellation
(with or without notice, lapse of time or both) of, any agreement, credit
facility, debt or instrument (evidencing a Company or Subsidiary debt or otherwise) or
other understanding to which the Company or any Subsidiary is a party or by which any
property or asset of the Company or any Subsidiary is bound or affected, or (iii) subject

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to the Required Approvals, result in a violation of any law, rule, regulation, order, judgment,
injunction, decree or other restriction of any court or governmental authority to which the
Company or a Subsidiary is subject (including federal and state securities laws and
regulations and the rules and regulations of any self-regulatory organization to which the
Company or its securities are subject), or by which any property or asset of the Company or
a Subsidiary is bound or affected; except in the case of each of clauses (ii) and (iii),
such as would not, individually or in the aggregate, have or reasonably be expected to
result in a Material Adverse Effect.

     (d) Issuance of the Shares; Reservation of Common Stock. The Shares have been
duly authorized and, when issued and paid for in accordance with this Agreement, will be
duly and validly issued, fully paid and nonassessable. The Company has reserved from its
duly authorized capital stock the maximum number of shares of Common Stock issuable pursuant
to this Agreement. The issuance by the Company of the Shares has been registered under the
Securities Act. The Registration Statement is effective and available for the issuance,
offering and sale of the Shares and the Company has not received any notice that the
Commission has issued or intends to issue a stop-order with respect to the Registration
Statement or that the Commission otherwise has suspended or withdrawn the effectiveness of
the Registration Statement, either temporarily or permanently, or intends or has threatened
in writing to do so. The “Plan of Distribution” section under the Registration Statement
permits the issuance and sale of the Shares hereunder. Except as described in Section 4.6,
and except to the extent the Purchaser is an affiliate of the Company, and assuming the
accuracy of the representations and warranties of the Purchaser herein, the Shares at the
time of delivery will be freely transferable and tradeable by the Purchaser without
restriction created by the Company. The Company has filed all applications and other
documents necessary for the Shares to be listed on The Nasdaq Global Select Market, subject
only to official notice of issuance.

     (e) Capitalization. The number of shares and type of all authorized, issued
and outstanding capital stock of the Company, and all shares of Common Stock reserved for
issuance under the Company’s various option and incentive plans, is set forth in the SEC
Reports. All outstanding shares of capital stock are duly authorized, validly issued, fully
paid and nonassessable and have been issued in compliance with all applicable securities
laws. Except as set forth in the SEC Reports, no securities of the Company are entitled to
preemptive or similar rights, and no Person has any right of first refusal, preemptive
right, right of participation, or any similar right to participate in the transactions
contemplated by the Transaction Documents. Except as a result of the purchase and sale of
the Shares or except as disclosed in the SEC Reports, there are no outstanding options,
warrants, scrip rights to subscribe to, calls or commitments of any character whatsoever
relating to, Common Stock Equivalents, or contracts, commitments, understandings or
arrangements by which the Company or any Subsidiary is or may become bound to issue
additional shares of Common Stock, or Common Stock Equivalents. There are no anti-dilution
or price adjustment provisions contained in any outstanding security issued by the Company
(or in any agreement providing rights to
security holders) other than under the Company’s incentive plan. The issue and sale of
the Shares will not, immediately or with the passage of time,
obligate the Company to issue shares of Common Stock or other securities to any Person (other than the

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Purchaser) and will
not result in a right of any holder of Company securities to adjust the exercise,
conversion, exchange or reset price under such securities.

     (f) SEC Reports; Financial Statements. The Company has furnished or made
available to the Purchaser true, correct and complete copies of all reports required to be
filed by it under the Exchange Act, including pursuant to Section 13(a) or 15(d) thereof,
for all periods subsequent to December 31, 2006 (the foregoing materials, including the
exhibits thereto, being collectively referred to herein as the “SEC Reports”). As
of their respective dates, the SEC Reports complied in all material respects with the
requirements of the Exchange Act and the rules and regulations of the Commission promulgated
thereunder, and none of the SEC Reports, when filed, contained any untrue statement of a
material fact or omitted to state a material fact required to be stated therein or necessary
in order to make the statements therein, in the light of the circumstances under which they
were made, not misleading. The Registration Statement and any prospectus included therein,
including the Prospectus Supplement to be filed covering the transactions covered hereby,
comply or will comply, as the case may be, in all material respects with the requirements of
the Securities Act and the rules and regulations of the Commission promulgated thereunder,
and none of the Registration Statement or any such prospectus contains or contained any
untrue statement of a material fact or omits or omitted to state a material fact required to
be stated therein or necessary in order to make the statements therein, in the case of any
prospectus, in the light of the circumstances under which they were made, not misleading.
The financial statements of the Company included in the SEC Reports comply as to form in all
material respects with applicable accounting requirements and the rules and regulations of
the Commission with respect thereto as in effect at the time of filing. Such financial
statements have been prepared in accordance with United States generally accepted accounting
principles applied on a consistent basis during the periods involved (“GAAP”),
except as may be otherwise specified in such financial statements or the notes thereto and
except that unaudited financial statements may not contain all footnotes required by GAAP,
and fairly present in all material respects the financial position of the Company and its
consolidated Subsidiaries as of and for the dates thereof and the results of operations and
cash flows for the periods then ended, subject, in the case of unaudited statements, to
normal, immaterial, year-end audit adjustments.

     (g) Title to Properties. The Company and each Subsidiary has (i) defensible
title to all their interests in the oil and gas properties described in the Registration
Statement and the Prospectus Supplement as being owned or leased by them, title
investigations having been carried out by the Company in accordance with customary practice
in the oil and gas industry, and (ii) good and marketable title to all other real property
and all personal property described in the Registration Statement and the Prospectus
Supplement as being owned by them, in each case free and clear of all liens, encumbrances,
claims, security interests and defects, except (A) such as would not have a Material Adverse
Effect, (B) security interests securing loans under the Company’s senior secured revolving
credit facility and second lien credit facility, (C) royalties,
overriding royalties and other burdens under oil and gas leases, (D) easements,
restrictions, rights-of-way and other matters that commonly affect oil and gas properties
and (E) liens and encumbrances under gas sales contracts, geophysical exploration

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agreements, operating agreements, farmout agreements, participation agreements, unitization,
pooling and commutation agreements, declarations and orders and gas sales contracts,
securing payment of amounts not yet due and payable and of a scope and nature customary in
the oil and gas industry. All property (other than oil and gas properties) held under lease
by the Company and each Subsidiary is held by them under valid, existing and enforceable
leases, free and clear of all liens, encumbrances, claims, security interests and defects,
except such as would not have a Material Adverse Effect. 

     (h) Acknowledgment Regarding Purchaser’s Purchase of Shares. The Company
acknowledges and agrees that the Purchaser is acting solely in the capacity of an arm’s
length purchaser with respect to the Transaction Documents and the transactions contemplated
hereby. The Company further acknowledges that the Purchaser is not acting as a financial
advisor or fiduciary of the Company (or in any similar capacity) with respect to this
Agreement and the transactions contemplated hereby and any advice given by the Purchaser or
any of its respective representatives or agents in connection with this Agreement and the
transactions contemplated hereby is merely incidental to the Purchaser’s purchase of the
Shares. The Company further represents to the Purchaser that the Company’s decision to
enter into this Agreement has been based solely on the independent evaluation of the
transactions contemplated hereby by the Company and its representatives.

     (i) Disclosure Documents. The Disclosure Documents together with the Purchase
Agreement do not contain any untrue statement of a material fact or omit to state any
material fact required to be stated therein or necessary in order to make the statements
therein, in the light of the circumstances under which they were made, not misleading.

     (j) No Material Adverse Effect. Subsequent to the dates as of which information
is given in the Disclosure Documents, except as disclosed in the Disclosure Documents, there
has been no event, occurrence or development that has had a Material Adverse Effect.

     (k) Litigation. There is no Action pending or, to the knowledge of the Company,
threatened against the Company which (i) adversely affects or challenges the legality,
validity or enforceability of any of the Transaction Documents or the Shares or (ii) would
have resulted in or reasonably be expected to result in a Material Adverse Effect. The
Commission has not issued any stop order or other order suspending the effectiveness of any
registration statement filed by the Company under the Exchange Act or the Securities Act.

     (l) Compliance With Law. Neither the Company nor any Subsidiary is or has been
in violation of any statute, rule or regulation of any governmental authority, including
without limitation all foreign, federal, state and local laws applicable to its
business, which violation would reasonably be expected to result in a Material Adverse
Effect.

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     (m) Sarbanes-Oxley Act. The Company is in material compliance with the
requirements that are currently applicable to it under the Sarbanes-Oxley Act of 2002, as
amended, and the rules and regulations thereunder, except where such noncompliance would not
have or reasonably be expected to result in a Material Adverse Effect.

     (n) Material Permits. The Company and each Subsidiary possesses all Material
Permits except where the failure to possess such permits would not have or reasonably be
expected to result in a Material Adverse Effect and neither the Company nor any Subsidiary
has received any written notice of Actions relating to the revocation or material
modification of any Material Permit.

     (o) Internal Accounting Controls. The Company and the Subsidiaries maintain a
system of internal accounting controls sufficient to provide reasonable assurance that (i)
transactions are executed in accordance with management’s general or specific
authorizations, (ii) transactions are recorded as necessary to permit preparation of
financial statements in conformity with GAAP and to maintain asset accountability, (iii)
access to assets is permitted only in accordance with management’s general or specific
authorization, and (iv) the recorded accountability for assets is compared with the existing
assets at reasonable intervals and appropriate action is taken with respect to any
differences. The Company has established disclosure controls and procedures (as defined in
Rules 13a-15 and 15d-15 under the Exchange Act) for the Company and designed such disclosure
controls and procedures to ensure that material information relating to the Company,
including its Subsidiaries, is made known to the certifying officers by others within those
entities to allow timely decisions regarding required disclosures. The Company’s certifying
officers have evaluated the effectiveness of the Company’s disclosure controls and
procedures as of a date within 90 days prior to the filing date of the Form 10-K for the
Company’s most recently ended fiscal year and the Form 10-Q for the Company’s most recently
ended fiscal quarter (each such applicable date, the “Evaluation Date”). The Company
presented in its most recently filed Form 10-K or Form 10-Q the conclusions of the
certifying officers about the effectiveness of the disclosure controls and procedures based
on their evaluations as of the Evaluation Date. Since the Evaluation Date and except as
disclosed in the SEC Reports, there have been no significant changes in the Company’s
internal control over financial reporting that have materially affected, or are reasonably
likely to materially affect, the Company’s internal control over financial reporting.

     3.2 Representations and Warranties of the Purchaser. The Purchaser hereby represents and
warrants as of the date hereof and as of the Closing Date to the Company as follows:

     (a) Organization; Authority. The Purchaser is an entity duly organized,
validly existing and in good standing under the laws of the jurisdiction of its organization
with full right, corporate, limited liability company or partnership power and authority to
enter into and to consummate the transactions contemplated by this Agreement and
otherwise to carry out its obligations hereunder. The execution, delivery and performance by
the Purchaser of this Agreement have been duly authorized by all necessary corporate,
limited liability company, partnership or similar action on the part of the Purchaser. This

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Agreement has been duly executed by the Purchaser, and when delivered by the Purchaser in
accordance with the terms hereof, will constitute the valid and legally binding obligation
of the Purchaser, enforceable against it in accordance with its terms, except (i) as limited
by general equitable principles and applicable bankruptcy, insolvency, reorganization,
moratorium and other laws of general application affecting enforcement of creditors’ rights
generally, (ii) as limited by laws relating to the availability of specific performance,
injunctive relief or other equitable remedies and (iii) insofar as indemnification and
contribution provisions may be limited by applicable law. The Purchaser was not formed and
is not being used solely for the purpose of purchasing or holding the Shares pursuant to
this Agreement.

     (b) Distribution. The Purchaser is purchasing the Shares for its own account
and not with a view to distribution. The Purchaser (i) does not have any agreement or
understanding, directly or indirectly, with any Person to distribute any of the Shares, and
(ii) has no present plan, intention or understanding and has made no arrangement to sell any
Shares at any predetermined time or for any predetermined price. The Purchaser is not
required to be registered as a broker-dealer under Section 15 of the Exchange Act.

     (c) Purchaser Status. The Purchaser is either (i) a Qualified Institutional
Buyer within the meaning of Rule 144A under the Securities Act or (ii) an “accredited
Purchaser” as defined in Rule 501(a) under the Securities Act.

     (d) No Trading. The Purchaser represents and warrants that, except as
otherwise disclosed to the Company in writing, from
September ___, 2007 (the “Discussion
Time”), up through the execution of this Agreement, neither the Purchaser nor its
Affiliates, directly or indirectly, executed any Short Sales or engaged in any other trading
in the Common Stock or any derivative security thereof or disclosed the existence of the
offering contemplated by this Agreement to any other person not subject to a non-disclosure
agreement or similar agreement regarding the same. Notwithstanding the foregoing, in the
case of a Purchaser and/or its Affiliates that is, individually or collectively, a
multi-managed investment vehicle whereby separate portfolio managers manage separate
portions of such Purchaser’s or Affiliates assets and the portfolio managers have no direct
knowledge of the investment decisions made by the portfolio managers managing other portions
of such Purchaser’s or Affiliates assets, the representation set forth above shall only
apply with respect to the portion of assets managed by the portfolio managers that have
knowledge about the financing transaction contemplated by this Agreement.

     The Company acknowledges and agrees that the Purchaser does not make or has not made any
representations or warranties with respect to the transactions contemplated hereby other than those
specifically set forth in this Section 3.2 and Section 4.6.

ARTICLE IV.

OTHER AGREEMENTS OF THE PARTIES

     4.1 Securities Laws Disclosure; Publicity. The Company shall, by 8:30 a.m., Eastern
time, on the Trading Day following the date hereof, issue a press release disclosing the material

12

 

terms of the transactions. The Company shall, by 8:30 a.m., Eastern time, by the second Trading
Day following the date hereof file (i) a Current Report on Form 8-K (which attaches as an exhibit a
form of this Agreement) disclosing the material terms of the transactions contemplated hereby, and
(ii) the Prospectus Supplement delivered by the Company in connection herewith with the Commission
via the EDGAR system on a timely basis. Notwithstanding the foregoing, the Company shall not
publicly disclose the name of the Purchaser, or include the name of the Purchaser in any filing
with the Commission or any regulatory agency or Trading Market, except as set forth in the exhibits
to be attached to the Form 8-K contemplated above, without the prior written consent of the
Purchaser (such consent not to be unreasonably withheld), except (i) as required by federal
securities law or (ii) to the extent such disclosure is required by law, judicial process or
Trading Market regulations, in which case the Company shall provide the Purchaser with prior notice
of such disclosure permitted under subclause (i) or (ii).

     4.2 Non-Public Information. Except in connection with the transactions contemplated
by the Transaction Documents prior to their public announcement, the Company covenants and agrees
that neither it nor any other Person acting on its behalf will provide the Purchaser or its agents
or counsel with any information that the Company believes constitutes material non-public
information, unless prior thereto the Purchaser shall have executed a written agreement regarding
the confidentiality and use of such information. The Company understands and confirms that the
Purchaser shall be relying on the foregoing representations in effecting transactions in securities
of the Company.

     4.3 Indemnification of Purchaser. Subject to the provisions of this Section 4.3, the
Company will indemnify and hold the Purchaser and its directors, officers, shareholders, partners,
members, employees and agents (each, a “Purchaser Party”) harmless from any and all losses,
liabilities, obligations, claims, contingencies, damages, costs and expenses, including all
judgments, amounts paid in settlements, court costs and reasonable attorneys’ fees and costs of
investigation that any such Purchaser Party may suffer or incur (the “Indemnified
Liabilities”) as a result of or relating to (a) any breach of any of the representations,
warranties, covenants or agreements made by the Company in this Agreement or in the other
Transaction Documents or (b) any Action brought or made against such Purchaser Party by a third
party as a derivative action brought on behalf of the Company and arising out of or resulting from
(i) the execution, delivery, performance or enforcement of the Transaction Documents or any other
certificate, instrument or document contemplated hereby or thereby or (ii) any transaction financed
or to be financed in whole or in part, directly or indirectly, with the proceeds of the issuance of
the Shares. The Company shall not be liable to the Purchaser under this provision in respect of
any Indemnified Liability if such liability arises out of any misrepresentation by the Purchaser in
Section 3.2 or Section 4.6 of this Agreement, any gross negligence or wrongful conduct of
Purchaser, or any violations of law, rule or regulation by the Purchaser. To the extent that the
foregoing undertaking by the Company may be unenforceable for any reason, the Company shall make
the maximum contribution to the payment and satisfaction of each of the Indemnified Liabilities
which is permissible under applicable law. If any action shall be brought against any
Purchaser Party in respect of which indemnity may be sought pursuant to this Agreement, such
Purchaser Party shall promptly (but in any event within 10 Business Days) notify the Company in
writing, and the Company shall have the right to assume the defense thereof with counsel of its own
choosing. Any Purchaser Party shall have the right to employ separate counsel in any such action
and participate in the defense thereof, but the fees and expenses of such counsel shall

13

 

be at the
expense of such Purchaser Party except to the extent that (i) the employment thereof has been
specifically authorized by the Company in writing, (ii) the Company has failed after a reasonable
period of time to assume such defense and to employ counsel or (iii) in such action there is, in
the reasonable opinion of such separate counsel, a material conflict on any material issue between
the position of the Company and the position of such Purchaser Party. The Company shall in any
event only be liable for the fees and expenses of one firm of attorneys for all Purchaser Parties
under this Agreement and the indemnified parties under all other securities purchase agreements
dated of even date herewith between the Company and other purchasers. The Company will not be
liable to any Purchaser Party under this Section 4.3 for any settlement by a Purchaser Party
effected without the Company’s prior written consent, which consent shall not be unreasonably
withheld or delayed.

     4.4 Reservation and Listing of Common Stock. The Company shall promptly secure the listing
of all of the Shares upon The Nasdaq Global Select Market or other national securities exchange and
automated quotation system, if any, upon which the Common Stock is then listed or quoted.

     4.5 Approval of Subsequent Equity Sales. The Company shall not issue shares of Common
Stock or Common Stock Equivalents if as a result of the transactions contemplated by this agreement
such issuance would require shareholder approval of the transactions contemplated by the
Transaction Documents pursuant to Rule 4350 of the NASD Marketplace Rules or any similar rule of
any other Trading Market, unless and until such shareholder approval is obtained prior to such
issuance.

     4.6 Trading Limitations and Restrictions on Short Sales. The Purchaser represents,
warrants, covenants and agrees that (a) from the Discussion Time through the date hereof, the
Purchaser did not, and (b) from the date hereof until the date the transactions contemplated by
this Agreement are first publicly announced by the Company as described in Section 4.1, the
Purchaser and its Affiliates will not, directly or indirectly, trade in the Common Stock or execute
or effect (or cause to be executed or effected) any transaction (including any Short Sale) in the
Common Stock or disclose the existence of the offering contemplated by this Agreement to any other
person not subject to a non-disclosure or similar agreement regarding the same. Furthermore, until
the date the transactions contemplated by this Agreement are first publicly announced by the
Company as described in Section 4.1, the Purchaser and its Affiliates will not directly or
indirectly sell, offer to sell, solicit offers to buy, dispose of, loan, pledge or grant any right
with respect to shares of Common Stock, except in compliance with all relevant securities laws and
regulations.

     Notwithstanding the foregoing, the Purchaser makes no representation, warranty or covenant
hereby that it will not engage in Short Sales in the securities of the Company after the time that
the transactions contemplated by this Agreement are first publicly announced by the
Company as described in Section 4.1. Notwithstanding the foregoing, in the case of a Purchaser
and/or its Affiliates that is, individually or collectively, a multi-managed investment vehicle
whereby separate portfolio managers manage separate portions of such Purchaser’s or Affiliates
assets and the portfolio managers have no direct knowledge of the investment decisions made by the
portfolio managers managing other portions of such Purchaser’s or Affiliates assets, the covenant
set forth above shall only apply with respect to the portion of assets managed by the

14

 

portfolio
managers that have knowledge about the financing transaction contemplated by this Agreement. Each
Purchaser agrees that it will not use any of the Shares acquired pursuant to this Agreement to
cover any short position in the Common Stock if doing so would be in violation of applicable
securities laws. For purposes hereof, “Short Sales” include, without limitation, all “short sales”
as defined in Rule 200 promulgated under Regulation SHO under the Exchange Act, whether or not
against the box, and all types of direct and indirect stock pledges, forward sales contracts,
options, puts, calls, short sales, swaps, “put equivalent positions” (as defined in Rule 16a-1(h)
under the Exchange Act) and similar arrangements (including on a total return basis), and sales and
other transactions through non-US broker dealers or foreign regulated brokers.

     4.7 Filing of Prospectus Supplement. The Company shall prepare the Prospectus
Supplement in a form approved by RBC (which approval may not be unreasonably withheld) and file
such Prospectus Supplement pursuant to Rule 424(b) under the Securities Act not later than the
Commission’s close of business on the second Business Day following the execution and delivery of
this Agreement, or, if applicable, such earlier time as may be required by the Rules. The Company
shall not file any amendment of the Registration Statement or the Prospectus Supplement relating to
the transactions contemplated by this Agreement unless the Company has furnished RBC a copy for its
review prior to filing and shall not file any such proposed amendment or supplement to which RBC
reasonably objects. The Company shall use its best efforts to prevent the issuance of any such
stop order and, if issued, to obtain as soon as possible the withdrawal thereof.

     4.8 Blue Sky Filings. The Company shall make all filings and reports, if any,
relating to the offer and sale of the Shares required under applicable securities or blue sky laws
of the states of the United States following the Closing.

ARTICLE V.

MISCELLANEOUS

     5.1 Fees and Expenses. Except as otherwise set forth in this Agreement, each party
shall pay the fees and expenses of its advisers, counsel, accountants and other experts, if any,
and all other expenses incurred by such party incident to the negotiation, preparation, execution,
delivery and performance of this Agreement. The Company shall pay all stamp and other taxes and
duties levied in connection with the sale of the Shares.

     5.2 Entire Agreement. The Transaction Documents, together with the exhibits and
schedules thereto, contain the entire understanding of the parties with respect to the subject
matter hereof and supersede all prior agreements and understandings, oral or written, with respect
to such matters, which the parties acknowledge have been merged into the Transaction Documents,
exhibits and schedules.

     5.3 Notices. Any and all notices or other communications or deliveries required or
permitted to be provided hereunder shall be in writing and shall be deemed given and effective on
the earliest of (a) the date of transmission, if such notice or communication is delivered via
facsimile at the facsimile number set forth on the signature pages attached hereto prior to 6:30
p.m. (New York City time) on a Trading Day, (b) the next Trading Day after the date of

15

 

transmission, if such notice or communication is delivered via facsimile at the facsimile number
set forth on the signature pages attached hereto on a day that is not a Trading Day or later than
6:30 p.m. (New York City time) on any Trading Day, (c) the second Trading Day following the date of
mailing, if sent by U.S. nationally recognized overnight courier service, or (d) in all other
cases, upon actual receipt by the party to whom such notice is required to be given. The address
for such notices and communications shall be as set forth on the signature pages attached hereto.

     5.4 Amendments; Waivers. No provision of this Agreement may be waived or amended
except in a written instrument signed, in the case of an amendment, by the Company and the
Purchaser or, in the case of a waiver, by the party against whom enforcement of any such waiver is
sought. No waiver of any default with respect to any provision, condition or requirement of this
Agreement shall be deemed to be a continuing waiver in the future or a waiver of any subsequent
default or a waiver of any other provision, condition or requirement hereof, nor shall any delay or
omission of either party to exercise any right hereunder in any manner impair the exercise of any
such right.

     5.5 Construction. The headings herein are for convenience only, do not constitute a
part of this Agreement and shall not be deemed to limit or affect any of the provisions hereof.
The language used in this Agreement will be deemed to be the language chosen by the parties to
express their mutual intent, and no rules of strict construction will be applied against any party.

     5.6 Successors and Assigns. This Agreement shall be binding upon and inure to the benefit
of the parties and their successors and permitted assigns. The Company may not assign this
Agreement or any rights or obligations hereunder without the prior written consent of the Purchaser
(except that no such prior written consent will be required in connection with the sale of all or
substantially all of the business, assets or properties of the Company by means of an asset
purchase, merger, consolidation or otherwise). The Purchaser may assign any or all of its rights
under this Agreement to any Affiliate of the Purchaser to whom the Purchaser assigns or transfers
any Shares, provided such transferee agrees in writing to be bound, with respect to the transferred
Shares, by the provisions hereof that apply to the Purchaser.

     5.7 No Third-Party Beneficiaries. This Agreement is intended for the benefit of the
parties hereto and their respective successors and permitted assigns and is not for the benefit of,
nor may any provision hereof be enforced by, any other Person.

     5.8 Governing Law. All questions concerning the construction, validity, enforcement
and interpretation of the Transaction Documents shall be governed by and construed and enforced in
accordance with the internal laws of the State of New York, without regard to the principles of
conflicts of law thereof. Each party hereby irrevocably submits to the exclusive jurisdiction of
the state and federal courts sitting in The City of New York, Borough of
Manhattan for the adjudication of any dispute hereunder or in connection herewith or with any
transaction contemplated hereby or discussed herein (including with respect to the enforcement of
any of the Transaction Documents), and hereby irrevocably waives, and agrees not to assert in any
suit, action or proceeding, any claim that it is not personally subject to the jurisdiction of any
such court, that such suit, action or proceeding is improper or inconvenient venue for such
proceeding. Each party hereby irrevocably waives personal service of process and consents to
process being served in any such suit, action or proceeding by mailing a copy thereof via

16

 

registered or certified mail or overnight delivery (with evidence of delivery) to such party at the
address in effect for notices to it under this Agreement and agrees that such service shall
constitute good and sufficient service of process and notice thereof. Nothing contained herein
shall be deemed to limit in any way any right to serve process in any manner permitted by law. The
parties hereby waive all rights to a trial by jury. If either party shall commence an action or
proceeding to enforce any provisions of the Transaction Documents, then the prevailing party in
such action or proceeding shall be reimbursed by the other party for its reasonable attorneys’ fees
and other costs and expenses incurred with the investigation, preparation and prosecution of such
action or proceeding.

     5.9 Survival. The representations, warranties, covenants and agreements contained
herein shall survive until one year following the Closing and delivery of the Shares.

     5.10 Execution. This Agreement may be executed in two or more counterparts, all of
which when taken together shall be considered one and the same agreement and shall become effective
when counterparts have been signed by each party and delivered to the other party, it being
understood that both parties need not sign the same counterpart. In the event that any signature
is delivered by facsimile transmission, such signature shall create a valid and binding obligation
of the party executing (or on whose behalf such signature is executed) with the same force and
effect as if such facsimile signature page were an original thereof.

     5.11 Severability. If any provision of this Agreement is held to be invalid or
unenforceable in any respect, the validity and enforceability of the remaining terms and provisions
of this Agreement shall not in any way be affected or impaired thereby and the parties will attempt
to agree upon a valid and enforceable provision that is a reasonable substitute therefor, and upon
so agreeing, shall incorporate such substitute provision in this Agreement.

     5.12 Replacement of Shares. If any certificate or instrument evidencing any Shares is
mutilated, lost, stolen or destroyed, the Company shall issue or cause to be issued in exchange and
substitution for and upon cancellation thereof, or in lieu of and substitution therefor, a new
certificate or instrument, but only upon receipt of evidence reasonably satisfactory to the Company
of such loss, theft or destruction and customary and reasonable indemnity or bond, if requested.
The applicants for a new certificate or instrument under such circumstances shall also pay any
reasonable third-party costs associated with the issuance of such replacement Shares.

     5.13 Remedies. In addition to being entitled to exercise all rights provided herein
or granted by law, including recovery of damages, the Purchaser and the Company will be entitled to
specific performance under the Transaction Documents. The parties agree that monetary damages may
not be adequate compensation for any loss incurred by reason of any breach of
obligations described in the foregoing sentence and hereby agrees to waive in any action for
specific performance of any such obligation the defense that a remedy at law would be adequate.

     5.14 Independent Nature of Purchaser’s Obligations and Rights. The obligations of the
Purchaser under the Transaction Documents or any similar transaction document are several and not
joint with the obligations of any other purchaser of the Common Stock on the Closing Date, and no
such purchaser shall be responsible in any way for the performance of the obligations of any other
purchaser under these Transaction Documents or any similar transaction document.

17

 

Nothing contained
herein or in any Transaction Document or in any other document executed in connection with the sale
of the Common Stock on the Closing Date, and no action taken by the Purchaser pursuant hereto or
any other purchase pursuant thereto, shall be deemed to constitute the purchasers as a partnership,
an association, a joint venture or any other kind of entity, or create a presumption that the
purchasers are in any way acting in concert or as a group with respect to such obligations or the
transactions contemplated by the Transaction Documents or any other document executed in connection
with the sale of the Company’s Common Stock on the Closing Date. The Purchaser shall be entitled
to independently protect and enforce its rights, including, without limitation, the rights arising
out of this Agreement or out of the other Transaction Documents, and it shall not be necessary for
any other purchaser to be joined as an additional party in any proceeding for such purpose. The
Purchaser has been represented by its own separate legal counsel in their review and negotiation of
the Transaction Documents. The Company represents that it has provided all purchasers of the
Common Stock on the Closing Date with the same terms for the purchase of the Common Stock and
substantially similar forms of transaction documents and that the Company has elected to do so for
the convenience of the Company and not because it was required or requested to do so by such
purchasers.

     5.15 Acknowledgment Regarding RBC. The Purchaser acknowledges that RBC is acting as a
placement agent for the Shares being offered hereby and will be compensated by the Company for
acting in such capacity. The Purchaser further acknowledges that RBC has acted solely as agent of
the Company in connection with the offering of the Shares by the Company. The Purchaser further
acknowledges that the provisions of Sections 2.3(b)(vi), 3.2(b) and this 5.15 are for the benefit
of and may be enforced by RBC.

[Signature Pages Follows]

18

 

          IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed by their
respective authorized signatories as of the date first indicated above.

	 	 	 	 	 	 	 
	Company : CARRIZO OIL & GAS, INC.	 	 	 	Address for Notice:
	 
	 	 	 	 	 	 
	By:
	 	 	 	 	 	 
	 

	 	 

Name:
	 	 	 	1000 Louisiana Street, Suite 1500
	 

	 	Title:
	 	 	 	Houston, Texas 77002
	 

	 	 	 	 	 	Attn: S.P. Johnson, IV, President and
	 

	 	 	 	 	 	         Chief Executive officer
	 

	 	 	 	 	 	Fax: (713) 328-1035
	 

	 	 	 	 	 	

With a copy to (which shall not constitute notice):

Baker Botts L.L.P.

One Shell Plaza

910 Louisiana Street

Houston, Texas 77002

Attn: Gene J. Oshman

Fax: 713-229-7778

[REMAINDER OF PAGE INTENTIONALLY LEFT BLANK

SIGNATURE PAGES FOR PURCHASER FOLLOWS]

19

 

[PURCHASER SIGNATURE PAGES TO CARRIZO SECURITIES PURCHASE

AGREEMENT]

     IN WITNESS WHEREOF, the undersigned have caused this Securities Purchase Agreement to be duly
executed by their respective authorized signatories as of the date first indicated above.

Name of Purchasing Entity:

Signature of Authorized Signatory of Investing Entity:

Name of Authorized Signatory:

Title of Authorized Signatory:

Email Address of Authorized Entity:

Fax:

Address for Notice of Purchasing Entity:

DWAC Instructions for Common Stock:

Subscription Amount: $

20exv4w5

 

Exhibit 4.5

AMENDMENT TO

SECOND AMENDED AND RESTATED REGISTRATION RIGHTS AGREEMENT

     Pursuant to Sections 13.3 and 13.4 of the Second Amended and Restated Registration Rights
Agreement, by and among Zars Pharma, Inc., a Delaware corporation (the “Company”), and
each of the holders of the Company’s Preferred Stock set forth on Exhibit A, Exhibit B and Exhibit
C thereto (the “Preferred Investors”), dated as of August 30, 2004, as amended (the “Agreement”),
the Company, Zions First National Bank (“Zions Bank”) and each of the undersigned Preferred
Investors hereby agree, effective as of this 7th day of September, 2007, to the
amendments (the “Amendment”) set forth below. Capitalized terms used but not defined herein have
the meanings given them in the Agreement.

Recitals

     Whereas, the Company and the undersigned Preferred Investors wish to amend
certain terms of the Agreement as described below;

     Whereas, pursuant to the terms of the Agreement, the Agreement may be amended by the
Company and the holders of a majority of the Registrable Securities (as defined in the Agreement)
(the “Required Holders”); and

     Whereas, the undersigned Preferred Investors constitute the Required Holders.

     Now, Therefore, the parties hereto agree as follows:

Agreement

     1. The definition of “Holder” set forth in Section 1 of the Agreement is hereby amended and
restated to read in its entirety as set forth below:

“’Holder’ shall mean (i) Zions First National Bank, (ii) a Preferred Investor and
(iii) any holder of Registrable Securities to whom the registration rights granted
by this Agreement have been transferred by a Holder in compliance with Section 10 of
this Agreement, in each case at any time during which such Holder holds Registrable
Securities.”

     2. The definition of “Qualified IPO” set forth in Section 1 of the Agreement is hereby amended
and restated to read in its entirety as set forth below:

“’Qualified IPO’ means the closing of a firm underwritten public offering of shares
of the Common Stock of the Company.”

     3. The definition of “Registrable Securities” set forth in Section 1 of the Agreement is
hereby amended and restated to read in its entirety as set forth below:

“’Registrable Securities’ shall mean (i) Shares issued or issuable pursuant to the
conversion of Series Preferred or upon the exercise and conversion of any

 

 

warrants or options to purchase Series Preferred, (ii) Shares issued or issuable
pursuant to that certain warrant to purchase 11,700 Shares issued to Zions First
National Bank on June 28, 2007 and (iii) any Shares issued as a dividend, stock
split or other distribution with respect to or in exchange for or in replacement of
such Shares referenced in clause (i) or (ii) above; provided, however, that
Registrable Securities shall not include any Shares which have previously been
registered or which have been sold to the public either pursuant to a registration
statement or are eligible for sale under and have been sold pursuant to Rule 144, or
which have been sold in a private transaction in which the transferor’s rights under
this Agreement are not assigned or are not assignable.”

     4. This Amendment may be executed in any number of counterparts, each of which may be executed
by less than all of the parties hereto and each of which shall constitute one and the same
instrument.

     5. The Company and the undersigned Preferred Investors consent to a restatement of the
Agreement to incorporate this Amendment.

     6. This Amendment shall be effective upon its execution by the Company, Zions Bank and the
Required Holders.

     7. Upon execution of this Amendment by the Company, Zions Bank and the Required Holders, Zions
Bank shall become a party to the Agreement and shall be (i) included within the term “Holder” for
all purposes thereof and (ii) treated as a Preferred Holder for purposes of Section 13.4 and 13.5
thereof.

     8. This Amendment shall be construed in accordance with and governed by the laws of the State
of Utah, without regard to principles of conflicts of laws thereof.

[Signatures follow]

 

 

     In Witness Whereof, the parties hereto have executed this Amendment to
Second Amended and Restated Registration Rights Agreement as of the date set forth in
the first paragraph hereof.

	 	 	 
	Zars Pharma, Inc.

	 	Zions First National Bank
	 
	 	 
	By: /s/ Robert Lippert

	 	By: /s/ Thomas C. Etzel
	Name: Robert Lippert

	 	Name: Thomas C. Etzel
	Title: President and Chief
Executive Officer

	 	Title: Senior Vice President

 

 

	 	 	 
	Shares Held:	 	Stockholder:
	 
	 	 
	Common Stock: -0-

	 	Draper Associates, L.P
	Series A Preferred: -0-
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: 33,507

	 	By: /s/ Timothy C. Draper
	 

	 	          Name: Timothy C. Draper
	 

	 	          Title    General Partner
	 

	 	Date: August 31, 2007
	 
	 	 
	Common Stock: -0-

	 	Draper Fisher Jurvetson Eplanet Partners Fund, LLC
	Series A Preferred: -0-
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: 16,313
	 	 
	 

	 	By: /s/ John Fisher
	 

	 	          Name: John Fisher
	 

	 	          Title    Managing Member
	 

	 	Date: August 31, 2007
	 
	 	 
	Common Stock: -0-

	 	Draper Fisher Jurvetson Eplanet Ventures GMBH & Co. KG
	Series A Preferred: -0-
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: 13,866

	 	By: /s/ John Fisher
	 

	 	          Name John Fisher
	 

	 	          Title    Managing Director
	 

	 	Date: August 31, 2007

 

 

	 	 	 
	Shares Held:	 	Stockholder:
	 
	 	 
	Common Stock: -0-

	 	Draper Fisher Jurvetson Eplanet Ventures L.P.
	Series A Preferred: -0-
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: 785,482
	 	 
	 

	 	By: /s/ John Fisher
	 

	 	          Name John Fisher
	 

	 	          Title    Managing Director
	 

	 	Date: August 31, 2007
	 
	 	 
	Common Stock: -0-

	 	Draper Fisher Jurvetson Fund VII, L.P.
	Series A Preferred: -0-
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: 1,237,195

	 	By: /s/ John Fisher
	 

	 	          Name John Fisher
	 

	 	          Title    Managing Director
	 

	 	Date: August 31, 2007
	 
	 	 
	Common Stock: -0-

	 	Draper Fisher Jurvetson Partners VII, LLC
	Series A Preferred: -0-
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: 18,042
	 	 
	 

	 	By: /s/ John Fisher
	 

	 	          Name John Fisher
	 

	 	          Title    Managing Member
	 

	 	Date: August 31, 2007
	 
	 	 
	Common Stock: -0-

	 	vSpring II, LP
	Series A Preferred: -0-
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: 481,860
	 	 
	 

	 	By: /s/ Dinesh Patel
	 

	 	          Name Dinesh Patel
	 

	 	          Title    Managing Director
	 

	 	Date: August 31, 2007
	 
	 	 
	Common Stock: -0-

	 	vSpring Partners II, LP
	Series A Preferred: -0-
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: 7,537

	 	By: /s/ Dinesh Patel
	 

	 	          Name Dinesh Patel
	 

	 	          Title    Managing Director
	 

	 	Date: August 31, 2007

 

 

	 	 	 
	Shares Held:	 	Stockholder:
	 
	 	 
	Common Stock: 1,293

	 	Wasatch Partners II, LLC
	Series A Preferred: -0-
	 	 
	Series B Preferred: 1,710
	 	 
	Series C Preferred: 3,262

	 	By: /s/ Todd J. Stevens
	 

	 	          Name Todd J. Stevens
	 

	 	          Title    Managing Director
	 

	 	Date: August 30, 2007
	 
	 	 
	Common Stock: 141,152

	 	Wasatch Venture Fund II, LLC
	Series A Preferred: 102,881
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: -0-

	 	By: /s/ Todd J. Stevens
	 

	 	          Name Todd J. Stevens
	 

	 	          Title    Managing Director
	 

	 	Date: August 30, 2007
	 
	 	 
	Common Stock: -0-

	 	Zions SBIC, LLC
	Series A Preferred: -0-
	 	 
	Series B Preferred: 341,880
	 	 
	Series C Preferred: -0-

	 	By: /s/ Todd J. Stevens
	 

	 	          Name Todd J. Stevens
	 

	 	          Title    Managing Director
	 

	 	Date: August 30, 2007

 

 

	 	 	 
	Shares Held:	 	Stockholder:
	 
	 	 
	Common Stock: 245,773

	 	Ted Stanley Family Limited Partnership
	Series A Preferred: 102,880
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: -0-

	 	By: /s/ Ted Stanley
	 

	 	          Name Theodore H. Stanley
	 

	 	          Title    General Partner
	 

	 	Date: August 29, 2007
	 
	 	 
	Common Stock: 40,251

	 	Susan and Theodore H. Stanley
	Series A Preferred: -0-
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: 163,132

	 	/s/ Ted Stanley
	 

	 	          Theodore H. Stanley
	 

	 	Date: August 29, 2007
	 
	 	 
	Common Stock: -0-

	 	Ellen and Theodore H. Stanley, JTWROS
	Series A Preferred: 102,880
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: -0-

	 	/s/ Ted Stanley
	 

	 	          Theodore H. Stanley
	 

	 	Date: August 29, 2007
	 
	 	 
	Common Stock: 166,821

	 	Stanley Research Foundation
	Series A Preferred: 51,440
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: 40,783

	 	By: /s/ Ted Stanley
	 

	 	          Name Theodore H. Stanley
	 

	 	          Title    President
	 

	 	Date: August 29, 2007
	 
	 	 
	Common Stock: 363,000

	 	Rigby Investments LLC
	Series A Preferred: 41,152
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: -0-

	 	By: /s/ Larry Rigby
	 

	 	          Name Larry Rigby
	 

	 	          Title    Manager
	 

	 	Date: August 27, 2007

 

 

	 	 	 
	Shares Held:	 	Stockholder:
	 
	 	 
	Common Stock: -0-

	 	Nancy A. Rigby Family Living Trust
	Series A Preferred: 20,576
	 	 
	Series B Preferred: -0-
	 	 
	Series C Preferred: -0-

	 	By: Nancy A. Rigby
	 

	 	          Name Nancy A. Rigby
	 

	 	          Title
	 

	 	Date: August 27, 2007
	 
	 	 
	Common Stock: 202,904
	 	 
	Series A Preferred: 12,346

	 	/s/ Michael Ashburn
	Series B Preferred: -0-

	 	          Michael Ashburn
	Series C Preferred: -0-

	 	Date: August 28, 2007

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00129-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00129-of-00352.parquet"}]]