Document:

Exhibit 4.60

    Exhibit
      4.60

     

    EXECUTION
      COPY

     

    Date:
      5th
      April 2004

    

     

    AMARIN
      CORPORATION PLC.

     

    AND

     

    RICHARD
      A.B. STEWART

     

    

    DEED
      OF VARIATION

    Relating
      To

    Employment
      Agreement Dated 23rd
      November 1998 As Amended

     

    
 

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    THIS
      DEED OF VARIATION
      is made
      the 5th
      April
      2004

     

    BETWEEN:

     

    
      	
              (1)

            	
              AMARIN
                CORPORATION PLC
                (formerly Ethical Holdings plc), a company incorporated in England
                and
                Wales (registered no. 002353920), whose registered office is 7 Curzon
                Street, London, W1J 5HG, England (“Amarin”);
                and

            

    

     

    
      	
              (2)

            	
              RICHARD
                A. B. STEWART
                of
                28 St. George’s Road, Twickenham, Middlesex, London, TW1 1QR (the
                “Executive”).

            

    

     

    WHEREAS:

     

    
      	
              (A)

            	
              Amarin
                and the Executive entered into an Employment Agreement dated 23rd
                November
                1998.

            

    

     

    
      	
              (B)

            	
              Amarin
                and the Executive have agreed to amend such Employment Agreement
                by and
                upon the terms of this Deed.

            

    

     

    NOW
      THIS DEED WITNESSES AS FOLLOWS:

     

    
      	1.  	
              DEFINITIONS
                AND INTERPRETATION

            

    

     

    
      	1.1.  	
              In
                this Deed, the “Original Agreement” shall mean the Employment Agreement
                dated 23rd November 1998 entered into by Amarin and the
                Executive.

            

    

     

    
      	1.2.  	
              Unless
                the context otherwise requires, all other words and expressions defined
                in
                the Original Agreement shall have the same meaning in this
                Deed.

            

    

     

    
      	1.3.  	
              Reference
                to clauses herein are to clauses in the Original
                Agreement.

            

    

     

    
      	2.  	
              INTRODUCTION

            

    

     

    This
      Deed
      is supplemental to the Original Agreement.

     

    
      	3.  	
              VARIATIONS

            

    

     

    The
      parties to this Deed agree that with effect from the date hereof the Original
      Agreement shall be varied carried as follows:

     

    
      	3.1.  	
              Clause
                1.2 (Position and Responsibilities) shall be varied by the deletion
                of the
                words “President and Chief Operating Officer of Ethical Holdings plc. The
                Executive shall have primary responsibility for restructuring the
                operations, relations with investors and corporate acquisitions” and the
                substitution therefore of the
                following:

            

    

     

    “Chief
      Executive Officer of Amarin Corporation plc. During the Employment Term and
      subject always to supervision by the Board, the Executive shall be responsible
      for and perform all the duties as would normally be expected of a chief
      executive in a company of a similar size and in the pharmaceutical
      sector.”

     

    
      
        
        

      

      
        -2-

        
          

        

      

      
        
        

      

    

     

    
      	3.2.  	
              Clause
                1.3 (Term) shall be varied by the deletion in its entirety of the
                existing
                Clause 1.3 to be replaced by the following new Clause
                1.3:

            

    

     

    “1.3
      Term.
      The
      employment of the Executive under this Agreement shall be deemed to have
      commenced on the Commencement Date and shall, subject to the provisions of
      this
      Agreement, continue unless or until terminated by either party giving no less
      than 12 months’ notice to the other party (the “Employment Term”).

     

    
      	3.3.  	
              Clause
                1.4 (Duties) shall be varied by the deletion of the words “and any
                Extension Terms” in the first
                sentence.

            

    

     

    
      	3.4.  	
              Clause
                2.1 (Base Salary) shall be varied by the deletion of the words and
“any
                Extension Terms,” in the third
                sentence.

            

    

     

    
      	3.5.  	
              Clause
                2.3 (Reimbursement of Expenses) shall be varied by the deletion of
                the
                words “and any Extension Terms,” in the second
                sentence.

            

    

     

    
      	3.6.  	
              Clause
                2.6 (Vacation) shall be varied by the deletion of the words “and any
                Extension Terms” in the first
                sentence.

            

    

     

    
      	3.7.  	
              Clause
                2.11 (Disability Benefits) shall be varied by the deletion of the
                words
                “or during any Extension Terms,” in the first
                sentence.

            

    

     

    
      	4.  	
              CONFIRMATION
                OF THE AGREEMENT

            

    

     

    Save
      as
      varied by this Deed, the parties hereto confirm that the Original Agreement
      shall continue in full force and effect in all respects.

     

    
      	5.  	
              EXECUTION
                AND DELIVERY

            

    

     

    Each
      of
      the parties to this document intends it to be a Deed and agrees that upon it
      being dated it shall be treated as having been delivered as a Deed.

     

    
      	6.  	
              MISCELLANEOUS

            

    

     

    
      	6.1.  	
              This
                Deed may be executed in several counterparts and upon due execution
                of all
                such counterparts by one or more parties, each counterpart shall
                be deemed
                to be an original hereof.

            

    

     

    
      	6.2.  	
              The
                provisions of Clauses 3.2 (Binding Agreement) and 3.3 (Governing
                Law) of
                the Original Agreement shall be incorporated into this
                Deed.

            

    

     

    
      
        
        

      

      
        -3-

        
          

        

      

      
        
        

      

    

    IN
      WITNESS
      whereof
      the parties have executed and delivered this Deed the date first above
      written.

     

    
      	
               

              EXECUTED
                as a DEED by

            	
               

              )

            
	
              AMARIN
                CORPORATION PLC

            	
              )

            
	
              acting
                by:-

               

            	
              )

               

            

    

    

     

    
      	
              Director

               

            	
              /s/Thomas
                Lynch        

               

            
	
              Secretary

               

            	
              /s/Jonathan
                Lamb        

               

            

    

    

     

    SIGNED
      as a DEED and delivered by

     

    /s/RICHARD
      A.B. STEWART

     

    in
      the presence of:

     

    Witness

     

    
      	
              Signature

               

            	
              /s/Jonathan
                Lamb        

               

            
	
              Name

               

            	
              /s/Jonathan
                Lamb        

               

            
	
              Address

            	
              7
                Curzon Street, London    

            

    

    

    

    
      
        
        

      

      
        -4-

        
          

        

      

      
        
        

      

    

    ETHICAL
      HOLDINGS plc

     

    RICHARD
      A.B. STEWART

     

    EMPLOYMENT
      AGREEMENT

     

    This
      EMPLOYMENT AGREEMENT (the “Agreement”) is entered into as of 23rd November, 1998
      (the “Commencement Date”) by and between Ethical Holdings plc (the “Company”)
      and Richard A.B. Stewart, an individual residing at 74 Selwyn Avenue, Richmond,
      Surrey, England, (the “Executive”).

     

    RECITALS

     

    A. The
      Company desires to secure for the Company the services and expertise of the
      Executive and to insure the availability of the Executive to the Company for
      an
      extended period.

     

    B. The
      Executive is willing to serve in the employ of the Company on a full time basis
      for said period upon the terms and conditions provided in this
      Agreement.

     

    C. To
      accomplish the foregoing the Company and the Executive have entered into this
      Employment Agreement.

     

    NOW,
      THEREFORE, in consideration of the premises and of the mutual covenants herein
      contained, the parties hereto hereby agree as follows:

     

    I. Employment,
      Term and Duties.

     

    1.1 Employment.
      The
      Company agrees to employ the Executive and the Executive agrees to remain in
      the
      employ of the Company, for the period stated Section 1.3, upon the terms
      and conditions provided in this Agreement.

     

    
      
        
        

      

      
        -5-

        
          

        

      

      
        
        

      

    

    

     

    1.2 Position
      and Responsibilities.
      During
      the period of his employment hereunder, the Executive agrees to serve as
      President and Chief Operating Officer of Ethical Holdings plc. The Executive
      shall have primary responsible for restructuring the operations, relations
      with
      investors and corporate acquisitions. The Executive shall report to the
      Chairman.

     

    1.3 Term.
      The
      employment of the Executive under this Agreement shall be deemed to have
      commenced as of the Commencement Date and shall continue for a period of
      twenty-four (24) full calendar months thereafter (the “Employment Term”) or
      until terminated in accordance with other provisions of this Agreement. This
      Agreement will be automatically renewed each annual anniversary date (Evergreen)
      unless either the Executive or the Company shall, upon six months written notice
      to the other, elect not to so renew this Agreement for any year. Such renewal(s)
      shall be referred to as “Extension Term(s)”.

     

    1.4 Duties.
      During
      the Employment Term and any Extension Terms, except for periods of illness
      or
      disability, reasonable vacation periods and leaves of absence, approved by
      the
      Board of Directors, the Executive shall devote substantially all of his business
      time, attention, skill and efforts to the faithful performance of his duties
      hereunder, to the best of his ability; provided, however, that with the prior
      approval of the Board of Directors, which approval shall not be unreasonably
      withheld, the Executive may serve from time to time and continue to serve,
      on
      the Boards of Directors of, and hold any other offices or positions in,
      companies or organizations which will not present any conflict of interest
      with
      the Company or any of its subsidiaries or affiliates or divisions, provided
      that
      such activities do not materially detract from the performance of the
      Executive’s duties pursuant to this Agreement. The indemnification rights
      provided to the Executive in Section 2.4 below, shall not, except with written
      approval by the Board of Directors of the Company, extend to such outside
      activities.

     

    
      
        
        

      

      
        -6-

        
          

        

      

      
        
        

      

    

    

     

    II. Compensation,
      Reimbursement of Expenses and Benefits.

     

    2.1 Base
      Salary.
      For the
      performance by the Executive of his duties under Article I of this Agreement
      during the Employment Term, the Company shall pay the Executive, as
      compensation, Two Hundred Thousand Pounds (£200,000) annually, payable monthly.
      The first year, the Executive will be paid One Hundred and Sixty Thousand Pounds
      (£160,000) which will increase to £200,000 upon the successful completion of the
      rights issue or alternative cash increase of at least Seven Million Five Hundred
      Thousand Dollars ($7,500,000) and that part of the £40,000 differential
      compensation, of year one will be paid to the Executive. During the Employment
      Term and any Extension Terms, the Executive’s Base Salary shall be reviewed on 1
      January 2000 and at least annually thereafter by the Board of Directors or
      by a
      committee designated by the Board of Directors, which Board or committee may,
      but need not, from time to time increase the rate of the Base Salary in
      recognition of the positive performance of the Executive or the
      Company.

     

    2.2 Bonus.
      In
      addition to the payment to the Executive of his Base Salary pursuant to Section
      2.1 hereof, the Company shall pay to the Executive an annual bonus (the “Bonus”)
      within 90 days after the end of the Company’s fiscal year. Payment of the Bonus
      will be dependent on the successful achievement of performance milestones.
      The
      performance milestones to be agreed with the Board of Directors as soon after
      the Commencement Date as is practically possible. Each performance milestone
      will be assigned a percentage weighting. The minimum amount of the Bonus to
      be
      paid for any such anniversary, if all the performance milestones have been
      achieved, shall be equal to 50% of the then annual rate of Base
      Salary.

     

    
      
        
        

      

      
        -7-

        
          

        

      

      
        
        

      

    

    

     

    2.3 Reimbursement
      of Expenses.
      The
      Company shall pay or reimburse the Executive for all travel and other expenses
      incurred by the Executive in the performance of his duties under this Agreement.
      During the Employment Term and any Extension Terms, the Company shall maintain
      and respect the practices and procedures applicable to such reimbursements
      from
      time to time adopted by the management of the Company.

     

    2.4 Liability
      Indemnification and Insurance.
      Company
      to provide full and complete Directors and Officers Insurance.

     

    2.5 Participation
      in Benefit Plans.
      The
      Company will provide medical insurance covering the Executive and the Executive
      may make additional contributions to extend the cover to his spouse and eligible
      children according to the program applied to employees of the Company
      generally.

     

    2.6 Vacation.
      The
      Executive shall be entitled to 23 days of paid vacation per year plus all
      Statutory days during the Employment Term and any Extension Terms. Holiday
      entitlement is calculated from 1st January each year and will be pro rated
      this
      year. The Company will reserve the right to stipulate when up to 2 days will
      be
      taken. Holiday entitlement will increase according to length of service. After
      5
      years completed service you will be entitled to 1 extra day for each additional
      year of service, up to a maximum of 5 extra days. Accrued holiday may only
      be
      used according to the policy applied to the employees of the
      Company.

     

    2.7 Automobile
      Allowance.
      The
      Executive shall receive a company car to a maximum value of £36,000. The cost of
      maintenance, tax, insurance and fuel will be met by the Company. Alternatively,
      the Executive may take a monthly automobile allowance (the “Auto Allowance”)
      equivalent to the car and costs defined above plus reimbursement for all
      reasonable 

     

    
      
        
        

      

      
        -8-

        
          

        

      

      
        
        

      

    

    and
      properly documented fuel expenses incurred and in accordance with the general
      expense reimbursement policy of the Company then in effect for senior
      executives.

     

    2.8 Initial
      Stock Option.
      The
      Executive shall be granted stock options in the amount of 2.5 million shares
      at
      an exercise price of USD $0.50. The stock options will vest as
      follows:

     

    2.0
      million on the Commencement Date.

     

    0.5
      million six months after the Commencement Date.

     

    These
      stock options will expire on the 10th anniversary of vesting.

     

    2.9 Performance
      Equity.
      The
      Executive shall be granted options to purchase commonstock of the Company on
      the
      terms and subject to the conditions set forth as follows.

     

    Performance
      Milestones:

     

    Upon
      the
      share price reaching $5.00: 350,000 stock options exercisable at
      $2.50.

     

    Upon
      the
      share price reaching $10.00: 350,000 stock options exercisable at
      $2.50.

     

    Upon
      the
      share price reaching $15.00: 300,000 stock options exercisable at
      $2.50.

     

    These
      stock options will expire on the 10th
      anniversary of vesting.

     

    2.10 Pension
      plan contributions.
      12% of
      annual salary paid on a monthly basis.

     

    2.11 Disability
      Benefits.
      In the
      event of the disability (as hereinafter defined) of the Executive during the
      Employment Term or during any Extension Term, the Company shall continue to
      pay
      to the Executive the Base Salary provided in Section 2.1 hereof, at the rate
      

     

    
      
        
        

      

      
        -9-

        
          

        

      

      
        
        

      

    

    which
      it
      has then reached, during the first six (6) months of the period of his
      disability (or during the remainder of the Employment Term, whichever is
      shorter), and thereafter at a rate equal to sixty percent (60%) of such Base
      Salary rate until the Executive reaches normal retirement age, and shall also
      pay to the Executive any bonuses to which he would have been entitled for the
      fiscal year in which the disability first occurs, had he not been so disabled.
      The Company will take out an appropriate insurance policy to cover the payments
      due following the first six months of disability. As used in this Agreement,
      the
      term “disability’ shall mean the inability of the Executive to perform his
      duties under this Agreement effectively, as determined by an independent
      physician selected with the approval of the Executive and the
      Company.

     

    2.12 Relocation.
      Package
      to include but not limited to:

     

    
      	·  	
              Three
                family house hunting trips to the final
                destination.

            

    

     

    
      	·  	
              Six
                months temporary living. Twelve months if constructing a new
                home.

            

    

     

    
      	·  	
              Payment
                of all costs (closing costs, points, commissions, etc.) on both the
                buying
                and selling side of the home transaction. Objective is to keep Executive
                whole.

            

    

     

    
      	·  	
              Moving
                and storage of all household goods, including cars and boat, with
                full
                replacement value insurance.

            

    

     

    
      
        
        

      

      
        -10-

        
          

        

      

      
        
        

      

    

    

     

    III. Miscellaneous.

     

    3.1 Fundamental
      Change of the Company.
      The
      Company will not consolidate or merge into or with another corporation, or
      transfer all or substantially all of its assets to another corporation, unless
      such other corporation shall assume or satisfy through termination and payment
      as provided herein, the duties and obligations of the Company under this
      Agreement.

     

    3.2 Binding
      Agreement.
      This
      Agreement shall be binding upon, and inure to the benefit of, the Executive
      and
      the Company and their respective successors and permitted assigns.

     

    3.3 Governing
      Law.
      This
      agreement shall be governed by and construed and interpreted in accordance
      with
      the laws of England whose courts shall be courts of competent
      jurisdiction.

     

    3.4 Substantive
      Contracts.
      Substantive contracts will be prepared which will include but not be limited
      to
      standard clauses with respect to Anti-compete, Confidential Information,
      Intellectual Property Rights.

     

    
      
        
        

      

      
        -11-

        
          

        

      

      
        
        

      

    

    IN
      WITNESS
      WHEREOF, the Company has caused this Agreement to be executed by its officers
      thereunto duly authorized, and the Executive has executed this Agreement, all
      as
      of the day and year first above written.

    
      	 	 
	
              “COMPANY”

               

            	
              “EXECUTIVE”

            
	
              Ethical
                Holdings plc

               

            	 
	
              By:
                /s/___________________________

               

            	
              By:
                /s/RAB Stewart        

            
	
              Title:
                Chairman

               

            	
              Richard
                A. B. Stewart

            
	
              Date:
                23rd
                November, 1998

            	
              Date:
                

            

    

    
 

    -12-Exhibit 4.61

    Exhibit
      4.61

     

    

     

    7
      Curzon
      Street, London W1J 5HG

    Tel:
      +44(0)20 7499 9009 Fax: +44(0)20 7499 9004

     

    September
      1, 2005

     

    Alan
      Cooke

    60
      Sandford Road

    Ranelagh

    Dublin
      6

    Ireland

     

    Dear
      Alan

     

    Amendment
      to your terms of employment

     

    I
      refer to
      your contract of employment dated 12th May 2004 (the “Contract”) and to our
      recent conversations in this regard.

     

    As
      discussed I set out the amendments agreed to your Contract.

     

    
      	
              1.

            	
              Your
                place of work is Dublin, Ireland and not 7 Curzon Street,
                London;

            

    

     

    
      	
              2.

            	
              Deletion
                of the words in clause 14 “Either you or Amarin may terminate your
                employment by the giving of at least 6 months’ prior written notice” and
                insertion of the words “Amarin may terminate your employment by the giving
                of at least 12 months prior written notice to you and you may terminate
                your employment by the giving of 6 months prior written notice to
                Amarin”.

            

    

     

    Kindly
      acknowledge your agreement to this amendment by signing below. Please could
      you
      then return this signed and dated letter to Jon for our records.

     

    Your
      sincerely

     

    /s/RAB
      Stewart        

    Rick
      Stewart

    Chief
      Executive Officer

     

    Agreed
      and
      accepted

     

    /s/Alan
      Cooke        

    Alan
      Cooke

     

    
      
        
        

      

      
        
        

        
          

        

      

      
        
        

      

    

    

     

    

     

    7
      Curzon
      Street, London W1J 5HG

    Tel:
      +44
      (0)20 7499 9009 Fax: +44 (0)20 7499 9004

     

    12th
      May
      2004

     

    Mr.
      Alan
      Cooke

    60
      Sandford Road

    Ranelagh

    Dublin
      6

    IRELAND

     

    Dear
      Alan,

     

    I
      refer to
      our recent conversations regarding your proposed appointment to the position
      of
      Chief Financial Officer of Amarin Corporation plc. Further to these I am
      delighted to offer you this position on the following terms:

     

    
      	
              1.

            	
              Your
                title will be Chief Financial Officer (“CFO”) and you will report to the
                Chief Financial Officer of Amarin Corporation plc (the “CEO”), the
                Chairman and the Board of Directors (“the Board”) of Amarin Corporation
                plc (“Amarin”). Specifically, you will be required to perform the role of
                a CFO and to perform such other duties as may be assigned to you
                by the
                CEO and/or the Board from time to time. You will also be a member
                of our
                Group Executive Committee and will be asked to contribute fully to
                our
                regular meetings and video conferences and to attend any off-site
                meetings.

            

    

     

    
      	
              2.

            	
              Your
                place of work will be 7 Curzon Street, Mayfair, London W1, although
                you
                may be required to work at other locations from time to time. Normal
                office hours are from 9.00 am to 5.00 pm Monday to Friday. However,
                your
                duties are critical to the smooth running of the operation and as
                such you
                may be required to work outside these
                hours.

            

    

     

    
      	
              3.

            	
              Amarin
                shall pay you the sum of 226,000 Euros gross per annum payable on
                or
                around the last Friday in each calendar month. Amarin will review
                the
                level of this payment at the end of each calendar year, commencing
                in your
                case on 1st
                January 2005.

            

    

     

    You
      will
      also receive a car allowance of 1,000 Euros per calendar month.

     

    
      	
              4.

            	
              You
                will be entitled to the grant of options over 375,000 ordinary shares
                in
                Amarin Corporation plc of £1 each (equivalent to 375,000 American
                Depositary Receipts) which will vest one third on the first anniversary
                of
                the option grant date and the reminder in equal amounts over the
                following
                two anniversary dates. These options will be priced and shall be
                approved
                and granted at the first remuneration committee meeting following
                the date
                of commencement of your
                appointment.

            

    

     

    
      
        
        

      

      
        -2-

        
          

        

      

      
        
        

      

    

    

     

    
      	
              5.

            	
              You
                will be appointed to the board of Amarin Corporation
                plc.

            

    

     

    
      	
              6.

            	
              You
                will be entitled to be considered for a discretionary bonus for each
                calendar year served with Amarin although any such bonus shall be
                payable
                in the absolute discretion of Amarin’s management having regard to the
                performance of the Amarin group as a whole and in the light of your
                own
                personal performance in accordance with agreed MBOs during such year.
                Additionally, you will be entitled to be considered for an annual
                discretionary grant of stock
                options.

            

    

     

    
      	
              7.

            	
              Subject
                to eligibility, you will be entitled to participate in Amarin’s (i)
                permanent health insurance scheme, and (ii) private medical insurance
                scheme, subject to the rules of each
                scheme.

            

    

     

    
      	
              8.

            	
              Subject
                to eligibility, you are eligible to join Amarin’s Group Stakeholder
                Personal Pension Scheme. If you join the scheme, contributions are
                made by
                Amarin at 6% and by you at least 3% of your basic monthly salary
                as set
                out in the scheme. Participation is subject to the terms and conditions
                of
                the scheme.

            

    

     

    
      	
              9.

            	
              Amarin
                shall reimburse you for all reasonable expenses that you are authorised
                to
                incur whilst carrying out your duties on behalf of Amarin. You must
                follow
                the correct claims procedure and provide invoices or other evidence
                of
                payment in order to be reimbursed.

            

    

     

    
      	
              10.

            	
              Your
                normal hours of work shall be 35 hours per week, although Amarin
                expects
                you to work such hours and at such times as may be reasonably necessary
                in
                order for you to carry out your duties effectively. There is no
                entitlement to payment for
                overtime.

            

    

     

    
      	
              11.

            	
              You
                are entitled to paid holidays of 24 days per annum, excluding statutory
                and customary holidays. The holiday year is from 1 January to 31
                December
                and unused holiday entitlement may not be carried forward. Holidays
                must
                be taken at times convenient to Amarin and sufficient notice of intention
                to take holiday must be given to accommodate the needs of the
                business.

            

    

     

    
      	
              12.

            	
              During
                working hours you shall devote all of your time, attention and skill
                to
                Amarin’s business and interests in a proper and efficient manner, and
                shall use your best efforts to further and promote Amarin’s business and
                to act loyally and faithfully to
                Amarin.

            

    

     

    
      	
              13.

            	
              During
                and after your engagement with Amarin you shall keep secret and shall
                not
                use or disclose (except as may be necessary in the course of your
                duties)
                any of Amarin’s confidential information, including (but not limited to)
                information relating to: Amarin’s business or that of its affiliates,
                associates, suppliers, customers, personnel; commercial and scientific
                data; strategic plans; intellectual property rights and trade
                secrets.

            

    

     

    
      	
              14.

            	
              Either
                you or Amarin may terminate your employment by the giving of at least
                6
                months’ prior written notice. During all or part of any period of notice,
                Amarin may at its absolute discretion require you not to attend any
                of its
                premises, and may require you to attend to only such duties as Amarin
                may
                specify. You agree that, during any part of any period of notice,
                you will
                not work for any other employer. Additionally, Amarin may pay a sum
                in
                lieu of such notice entitlement. In the event of involuntary termination
                of 

            

    

     

    
      
        
        

      

      
        -3-

        
          

        

      

      
        
        

      

    

    employment
      by Amarin all stock options will be vested and you will have 12 months from
      the
      date of termination to exercise such stock options.

     

    
      	
              15.

            	
              In
                cases of gross misconduct Amarin may terminate your engagement immediately
                without notice and without liability for compensation or damages.
                In the
                event of a dispute arising in respect of any such termination by
                Amarin
                this dispute will be governed by the laws of England and shall be
                subject
                to the exclusive jurisdiction of the English
                courts.

            

    

     

    
      	
              16.

            	
              You
                will commence your employment with Amarin on 18th
                May
                2004.

            

    

     

    
      	
              17.

            	
              This
                offer of employment is conditional
                upon:

            

    

     

    
      	
              a.

            	
              receipt
                by the Company of two satisfactory employment references, one of
                which
                must be given by your current employer. Please provide names and
                addresses
                of two referees, who may be contacted
                immediately.

            

    

     

    
      	
              b.

            	
              receipt
                of original professional and educational qualifications (where
                requested);

            

    

     

    
      	
              c.

            	
              all
                pre-employment checks being acceptable to the
                Company.

            

    

     

    You
      have
      seven days from the date of this letter to accept the offer. If you choose
      to
      accept the offer on the above terms and conditions, please sign and return
      the
      copy of this letter and both contracts to Jonathan Lamb. The contracts will
      be
      countersigned by the Company and you will be issued with a fully signed contract
      when you start work.

     

    We
      look
      forward to you joining our Company and I am sure you will have a successful
      and
      challenging career with Amarin.

     

    Signed
      for
      and on behalf of

    AMARIN
      CORPORATION PLC

     

    /s/RAB
      Stewart        

    RAB
      Stewart

    Chief
      Executive Officer

     

    Agreed
      and
      accepted

     

    /s/Alan
      Cooke        

    Alan
      Cooke

     

    Date:
      May
      12, 2004

     

    -4-

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