Document:

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                                                                   Exhibit 10.35

                                                               Customer No. 1101

                       MASTER LOAN AND SECURITY AGREEMENT

                  THIS AGREEMENT dated as of June 27, 2000, is made by Dyax
Corp. (the "Borrower"), a Delaware corporation having its principal place of
business and chief executive office at One Kendall Square, Building 600,
Cambridge, Massachusetts 02139, in favor of Transamerica Business Credit
Corporation, a Delaware corporation (the "Lender"), having its principal office
at Riverway II, West Office Tower, 9399 West Higgins Road, Rosemont, Illinois
60018.

                  WHEREAS, the Borrower has requested that the Lender make Loans
to it from time to time; and

                  WHEREAS, the Lender has agreed to make such Loans on the terms
and conditions of this Agreement.

                  NOW, THEREFORE, in consideration of the premises and to induce
the Lender to extend credit, the Borrower hereby agrees with the Lender as
follows:

                  SECTION 1. DEFINITIONS.

                  As used herein, the following terms shall have the following
meanings, and shall be equally applicable to both the singular and plural forms
of the terms defined:

AGREEMENT shall mean this Master Loan and Security Agreement together with all
schedules and exhibits hereto, as amended, supplemented, or otherwise modified
from time to time.

APPLICABLE LAW shall mean the laws of the State of Illinois (or any other
jurisdiction whose laws are mandatorily applicable notwithstanding the parties'
choice of Illinois law) or the laws of the United States of America, whichever
laws allow the greater interest, as such laws now exist or may be changed or
amended or come into effect in the future.

BUSINESS DAY shall mean any day other than a Saturday, Sunday, or public holiday
or the equivalent for banks in New York City.

CODE shall have the meaning specified in Section 8(d).

COLLATERAL shall have the meaning specified in Section 2.

COLLATERAL ACCESS AGREEMENT shall mean any landlord waiver, mortgagee waiver,
bailee letter, or similar acknowledgement of any warehouseman or processor in
possession of any Equipment, in each case substantially in the form of Exhibit
B.

EFFECTIVE DATE shall mean the date on which all of the conditions specified in
Section 3.3 shall have been satisfied.

EQUIPMENT shall have the meaning specified in Section 2.

EVENT OF DEFAULT shall mean any event specified in Section 7.

FINANCIAL STATEMENTS shall have the meaning specified in Section 6.1.

GAAP shall mean generally accepted accounting principles in the United States of
America, as in effect from time to time.

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LOANS shall mean the loans and financial accommodations made by the Lender to
the Borrower in accordance with the terms of this Agreement and the Notes.

LOAN DOCUMENTS shall mean, collectively, this Agreement, the Notes, and all
other present and future documents, agreements, certificates, instruments, and
opinions delivered by the Borrower under, in connection with or relating to this
Agreement, or any other present or future instrument or agreement between Lender
and Borrower, as each of the same may be amended, modified, extended, restated
or supplemented from time to time.

MATERIAL ADVERSE CHANGE shall mean, with respect to any Person, a material
adverse change in the business, operations, results of operations, assets,
liabilities, or condition (financial or otherwise) of such Person taken as a
whole.

MATERIAL ADVERSE EFFECT shall mean, with respect to any Person, a material
adverse effect on the business, operations, results of operations, assets,
liabilities, or condition (financial or otherwise) of such Person taken as a
whole.

NOTE shall mean each Promissory Note made by the Borrower in favor of the
Lender, as amended, supplemented, or otherwise modified from time to time, in
each case substantially in the form of Exhibit C.

OBLIGATIONS shall mean and include all loans (including the Loans), advances,
debts, liabilities, obligations, covenants and duties owing by Borrower to
Lender of any kind or nature, present or future, whether or not evidenced by the
Note or any note, guaranty or other instrument, whether or not arising under or
in connection with, this Agreement, any other Loan Document or any other present
or future instrument or agreement, whether or not for the payment of money,
whether arising by reason of an extension of credit, opening, guaranteeing or
confirming of a letter of credit, loan, guaranty, indemnification or in any
other manner, whether direct or indirect (including those acquired by
assignment, purchase, discount or otherwise), whether absolute or contingent,
due or to become due, now due or hereafter arising and however acquired
(including without limitation all loans previously made by Lender to Borrower).
The term includes, without limitation, all interest (including interest accruing
on or after a bankruptcy, whether or not an allowed claim), charges, expenses,
commitment, facility, closing and collateral management fees, letter of credit
fees, reasonable attorneys' fees, taxes and any other sum properly chargeable to
Borrower under this Agreement, the other Loan Documents or any other present or
future agreement between Lender and Borrower.

PERMITTED LIENS shall mean such of the following as to which no enforcement,
collection, execution, levy, or foreclosure proceeding shall have been
commenced: (a) liens for taxes, assessments, and other governmental charges or
levies or the claims or demands of landlords, carriers, warehousemen, mechanics,
laborers, materialmen, and other like Persons arising by operation of law in the
ordinary course of business for sums which are not yet due and payable, or liens
which are being contested in good faith by appropriate proceedings diligently
conducted and with respect to which adequate reserves are maintained to the
extent required by GAAP; (b) deposits or pledges to secure the payment of
worker's compensation, unemployment insurance, or other social security benefits
or obligations, public or statutory obligations, surety or appeal bonds, bid or
performance bonds, or other obligations of a like nature incurred in the
ordinary course of business; (c) licenses, restrictions, or covenants for or on
the use of the Equipment which do not materially impair either the use of the
Equipment in the operation of the business of the Borrower or the value of the
Equipment; and (d) attachment or judgment liens that do not constitute an Event
of Default.

PERSON shall mean any individual, sole proprietorship, partnership, limited
liability partnership, joint venture, trust, unincorporated organization,
association, corporation, limited liability company, institution, entity, party,
or government (including any division, agency, or department thereof), and the
successors, heirs, and assigns of each.

SCHEDULE shall mean each Schedule in the form of Schedule A hereto delivered by
the Borrower to the Lender from time to time.

SOLVENT means, with respect to any Person, that as of the date as to which such
Person's solvency is measured:

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                  (a) the fair saleable value of its assets is in excess of the
total amount of its liabilities (including contingent liabilities as valued in
accordance with GAAP) as they become absolute and matured;

                  (b) it has sufficient capital to conduct its business; and

                  (c) it is able generally to meet its debts as they mature.

TAXES shall have the meaning specified in Section 5.5.

                  SECTION 2. CREATION OF SECURITY INTEREST; COLLATERAL. The
Borrower hereby assigns and grants to the Lender a continuing general, first
priority lien on, and security interest in, all the Borrower's right, title, and
interest in and to the collateral described in the next sentence (the
"Collateral") to secure the payment and performance of all the Obligations. The
Collateral consists of all equipment set forth on all the Schedules delivered
from time to time under the terms of this Agreement (the "Equipment"), together
with all present and future additions, parts, accessories, attachments,
substitutions, repairs, improvements, and replacements thereof or thereto, and
any and all proceeds thereof, including, without limitation, proceeds of
insurance and all manuals, blueprints, know-how, warranties, and records in
connection therewith, all rights against suppliers, warrantors, manufacturers,
sellers, or others in connection therewith, and together with all substitutes
for any of the foregoing.

                  SECTION 3. THE CREDIT FACILITY.

                           SECTION  3.1. BORROWINGS. Each  Loan  shall be in an
amount not less than $50,000, and in no event shall the sum of the aggregate
Loans made exceed the amount of the Lender's written commitment to the Borrower
in effect from time to time. Notwithstanding anything herein to the contrary,
the Lender shall be obligated to make the initial Loan and each other Loan only
after the Lender, in its sole discretion, determines that the applicable
conditions for borrowing contained in Sections 3.3 and 3.4 are satisfied. The
timing and financial scope of Lender's obligation to make Loans hereunder are
limited as set forth in a commitment letter executed by Lender and Borrower,
dated as of February 8, 2000 and attached hereto as EXHIBIT A (the "Commitment
Letter").

                           SECTION 3.2. APPLICATION OF PROCEEDS. The Borrower
shall not directly or indirectly use any proceeds of the Loans, or cause,
assist, suffer, or permit the use of any proceeds of the Loans, for any purpose
other than for the purchase, acquisition, installation, or upgrading of
Equipment or the reimbursement of the Borrower for its purchase, acquisition,
installation, or upgrading of Equipment.

                           SECTION 3.3. CONDITIONS TO INITIAL LOAN.

                  (a) The obligation of the Lender to make the initial Loan is
subject to the Lender's receipt of the following, each dated the date of the
initial Loan or as of an earlier date acceptable to the Lender, in form and
substance satisfactory to the Lender and its counsel:

                           (i) completed requests for information (Form UCC-11)
                  listing all effective Uniform Commercial Code financing
                  statements naming the Borrower as debtor and all tax lien,
                  judgment, and litigation searches for the Borrower as the
                  Lender shall deem reasonably necessary or desirable;

                           (ii) Uniform Commercial Code financing statements
                  (Form UCC-1) duly executed by the Borrower (naming the Lender
                  as secured party and the Borrower as debtor and in form
                  acceptable for filing in all jurisdictions that the Lender
                  deems reasonably necessary or desirable to perfect the
                  security interests granted to it hereunder) and, if
                  applicable, termination statements or other releases duly
                  filed in all jurisdictions that the Lender deems reasonably
                  necessary or desirable to perfect and protect the priority of
                  the security interests granted to it hereunder in the
                  Equipment related to such initial Loan;

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                           (iii) a Note duly executed by the Borrower evidencing
                  the amount of such Loan;

                           (iv) a Collateral Access Agreement duly executed by
                  the lessor or mortgagee, as the case may be, of each premises
                  where the Equipment is located;

                           (v) certificates of insurance required under Section
                  5.4 of this Agreement together with loss payee endorsements
                  for all such policies naming the Lender as lender loss payee
                  and as an additional insured;

                           (vi) a certificate of the Secretary or an Assistant
                  Secretary of the Borrower ("Secretary's Certificate")
                  certifying (A) that attached to the Secretary's Certificate is
                  a true, complete, and accurate copy of the resolutions of the
                  Board of Directors of the Borrower (or a unanimous consent of
                  directors in lieu thereof) authorizing the execution,
                  delivery, and performance of this Agreement, the other Loan
                  Documents, and the transactions contemplated hereby and
                  thereby, and that such resolutions have not been amended or
                  modified since the date of such certification and are in full
                  force and effect; (B) the incumbency, names, and true
                  signatures of the officers of the Borrower authorized to sign
                  the Loan Documents to which it is a party; (C) that attached
                  to the Secretary's Certificate is a true and correct copy of
                  the Articles or Certificate of Incorporation of the Company,
                  as amended, which Articles or Certificate of Incorporation
                  have not been further modified, repealed or rescinded and are
                  in full force and effect; (D) that attached to the Secretary's
                  Certificate of the Borrower is a true and correct copy of the
                  Bylaws, as amended, which Bylaws of the Company have not been
                  further modified, repealed or rescinded and are in full force
                  and effect; and (E) that attached to the Secretary's
                  Certificate is a valid Certificate of Good Standing issued by
                  the Secretary of the State of the Borrower's state of
                  incorporation; and

                           (vii) such other agreements and instruments as the
                  Lender deems necessary in its good faith business judgment in
                  connection with the transactions contemplated hereby.

                  (b) There shall be no pending or, to the best of Borrower's
knowledge after due inquiry, threatened in writing litigation, proceeding,
inquiry, or other action (i) seeking an injunction or other restraining order,
damages, or other relief with respect to the transactions contemplated by this
Agreement or the other Loan Documents or thereby or (ii) which affects or could
affect the business, operations, assets, liabilities, or condition (financial or
otherwise) of the Borrower, except, in the case of clause (ii), where such
litigation, proceeding, inquiry, or other action could not be expected to have a
Material Adverse Effect in the judgment of the Lender.

                  (c) The Borrower shall have paid all fees and expenses
required to be paid by it to the Lender as of such date.

                  (d) The security interests in the Equipment related to the
initial Loan granted in favor of the Lender under this Agreement shall have been
duly perfected and shall constitute first priority liens.

                           SECTION  3.4. CONDITIONS PRECEDENT TO EACH LOAN. The
obligation of the Lender to make each Loan is subject to the satisfaction of the
following conditions precedent:

                  (a) the Lender shall have received the documents, agreements,
and instruments set forth in Section 3.3(a)(i) through (v) applicable to such
Loan, each in form and substance satisfactory to the Lender and its counsel and
each dated the date of such Loan or as of an earlier date acceptable to the
Lender;

                  (b) the Lender shall have received a Schedule of the Equipment
related to such Loan, in form and substance satisfactory to the Lender and its
counsel, and the security interests in such Equipment related to such Loan
granted in favor of the Lender under this Agreement shall have been duly
perfected and shall constitute first priority liens;

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                  (c) all representations and warranties contained in this
Agreement and the other Loan Documents shall be true and correct on and as of
the date of such Loan as if then made, other than representations and warranties
that expressly relate solely to an earlier date, in which case they shall have
been true and correct as of such earlier date;

                  (d) no Event of Default or event which with the giving of
notice or the passage of time, or both, would constitute an Event of Default
shall have occurred and be continuing or would result from the making of the
requested Loan as of the date of such request; and

                  (e) the Borrower shall be deemed to have hereby reaffirmed and
ratified all security interests, liens, and other encumbrances heretofore
granted by the Borrower to the Lender.

                  SECTION 4. THE BORROWER'S REPRESENTATIONS AND WARRANTIES.

                           SECTION 4.1. GOOD STANDING; QUALIFIED TO DO BUSINESS.
The Borrower (a) is duly organized, validly existing, and in good standing under
the laws of the State of its organization, (b) has the power and authority to
own its properties and assets and to transact the businesses in which it is
presently, or proposes to be, engaged, and (c) is duly qualified and authorized
to do business and is in good standing in every jurisdiction in which the
failure to be so qualified could have a Material Adverse Effect on (i) the
Borrower, (ii) the Borrower's ability to perform its obligations under the Loan
Documents, or (iii) the rights of the Lender hereunder.

                           SECTION 4.2. DUE EXECUTION, ETC. The execution,
delivery, and performance by the Borrower of each of the Loan Documents to which
it is a party are within the powers of the Borrower, do not contravene the
organizational documents, if any, of the Borrower, and do not (a) violate any
law or regulation, or any order or decree of any court or governmental
authority, (b) conflict with or result in a breach of, or constitute a default
under, any material indenture, mortgage, or deed of trust or any material lease,
agreement, or other instrument binding on the Borrower or any of its properties,
or (c) require the consent, authorization by, or approval of or notice to or
filing or registration with any governmental authority or other Person, except
for the filing of UCC-1 financing statements. This Agreement is, and each of the
other Loan Documents to which the Borrower is or will be a party, when delivered
hereunder or thereunder, will be, the legal, valid, and binding obligation of
the Borrower enforceable against the Borrower in accordance with its terms,
except as enforceability may be limited by bankruptcy, insolvency, or similar
laws affecting creditors' rights generally and by general principles of equity.

                           SECTION 4.3. SOLVENCY; NO LIENS. The Borrower is
Solvent and will be Solvent upon the completion of all transactions contemplated
to occur hereunder (including, without limitation, the Loan to be made on the
Effective Date); the security interests granted herein constitute and shall at
all times constitute the first and only liens on the Collateral other than
Permitted Liens; and the Borrower is, or will be at the time additional
Collateral is acquired by it, the absolute owner of the Collateral with full
right to pledge, sell, consign, transfer, and create a security interest
therein, free and clear of any and all claims or liens in favor of any other
Person other than Permitted Liens.

                           SECTION 4.4. NO JUDGMENTS, LITIGATION. No judgments
are outstanding against the Borrower nor, except as set forth on Schedule A
hereto, is there now pending or, to the best of the Borrower's knowledge
threatened in writing any litigation, contested claim, or governmental
proceeding by or against the Borrower except judgments and pending or threatened
litigation, contested claims, and governmental proceedings which would not, in
the aggregate, have a Material Adverse Effect on the Borrower.

                           SECTION 4.5. NO DEFAULTS. To the best of Borrower's
knowledge, after due inquiry, the Borrower is not in default or has not received
a written notice of default under any material contract, lease, or commitment to
which it is a party or by which it is bound. The Borrower knows of no dispute
regarding any contract, lease, or commitment which could have a Material Adverse
Effect on the Borrower.

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                           SECTION 4.6. COLLATERAL LOCATIONS. On the date
hereof, each item of the Collateral is located at the place of business
specified in the applicable Schedule.

                           SECTION 4.7. NO EVENTS OF DEFAULT. To the best of
Borrower's knowledge, after due inquiry, no Event of Default has occurred and is
continuing nor has any event occurred which, with the giving of notice or the
passage of time, or both, would constitute an Event of Default.

                           SECTION 4.8. NO LIMITATION ON LENDER'S RIGHTS.
Except as permitted herein, none of the Collateral is subject to contractual
obligations that may restrict or inhibit the Lender's rights or abilities to
sell or dispose of the Collateral or any part thereof after the occurrence of an
Event of Default.

                           SECTION 4.9.PERFECTION AND PRIORITY OF SECURITY
INTEREST. This Agreement creates a valid and, upon completion of all required
filings of financing statements, perfected first priority and exclusive security
interest in the Collateral, securing the payment of all the Obligations.

                           SECTION 4.10. MODEL AND SERIAL NUMBERS. The Schedules
set forth the true and correct model number and serial number of each item of
Equipment that constitutes Collateral.

                           SECTION 4.11. ACCURACY AND COMPLETENESS OF
INFORMATION. All data, reports, and information heretofore, contemporaneously,
or hereafter furnished by or on behalf of the Borrower in writing to the Lender
or for purposes of or in connection with this Agreement or any other Loan
Document, or any transaction contemplated hereby or thereby, are or will be true
and accurate in all material respects on the date as of which such data,
reports, and information are dated or certified and not incomplete by omitting
to state any material fact necessary to make such data, reports, and information
not misleading at such time. There are no facts now known to the Borrower which
individually or in the aggregate would reasonably be expected to have a Material
Adverse Effect and which have not been specified herein, in the Financial
Statements, or in any certificate, opinion, or other written statement
previously furnished by the Borrower to the Lender.

                           SECTION 4.12. PRICE OF EQUIPMENT. The cost of each
item of Equipment does not exceed the fair and usual price for such type of
equipment purchased in like quantity and reflects all discounts, rebates and
allowances for the Equipment (including, without limitation, discounts for
advertising, prompt payment, testing, or other services) given to the Borrower
by the manufacturer, supplier, or any other person.

                  SECTION 5. COVENANTS OF THE BORROWER.

                           SECTION 5.1. EXISTENCE, ETC. The Borrower shall:
(a) retain its existence and its current yearly accounting cycle, (b) maintain
in full force and effect all licenses, bonds, franchises, leases, trademarks,
patents, contracts, and other rights necessary or desirable to the profitable
conduct of its business unless the failure to do so could not reasonably be
expected to have a Material Adverse Effect on the Borrower, (c) continue in, and
limit its operations to, the same general lines of business as those presently
conducted by it, and (d) comply with all applicable laws and regulations of any
federal, state, or local governmental authority, except for such laws and
regulations the violations of which would not, in the aggregate, have a Material
Adverse Effect on the Borrower.

                           SECTION 5.2. NOTICE TO THE LENDER. As soon as
possible, and in any event within five days after the Borrower learns of the
following, the Borrower will give written notice to the Lender of (a) any
proceeding instituted or threatened in writing to be instituted by or against
the Borrower in any federal, state, local, or foreign court or before any
commission or other regulatory body (federal, state, local, or foreign)
involving a sum, together with the sum involved in all other similar
proceedings, in excess of $50,000 in the aggregate, (b) any contract that is
terminated or amended and which has had or could reasonably be expected to have
a Material Adverse Effect on the Borrower, (c) the occurrence of any Material
Adverse Change with respect to the Borrower, and (d) the occurrence of any Event
of Default or event or condition which, with notice or lapse of time or both,
would constitute an Event of Default, together with a statement of the action
which the Borrower has taken or proposes to take with respect thereto.

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                           SECTION 5.3. MAINTENANCE OF BOOKS AND RECORDS. The
Borrower will maintain books and records pertaining to the Collateral in such
detail, form, and scope as the Lender shall require in its commercially
reasonable judgment. The Borrower agrees that the Lender or its agents may enter
upon the Borrower's premises at reasonable times upon reasonable notice during
normal business hours, and at any time upon the occurrence and continuance of an
Event of Default, for the purpose of inspecting the Collateral and any and all
records pertaining thereto.

                           SECTION 5.4. INSURANCE. The Borrower will maintain
insurance on the Collateral under such policies of insurance, with such
insurance companies and, in such amounts reasonably satisfactory to Lender, and
covering such risks as are customarily insured against on the type of Collateral
financed hereunder and type of Borrower and as otherwise acceptable to Lender as
determined by Lender in its good faith business judgment. All such policies
shall be made payable to the Lender, in case of loss, under a standard
non-contributory "lender" or "secured party" clause and are to contain such
other provisions as the Lender may reasonably require to protect the Lender's
interests in the Collateral and to any payments to be made under such policies.
Certificates of insurance policies are to be delivered to the Lender, premium
prepaid, with the loss payable endorsement in the Lender's favor, and shall
provide for not less than thirty days' prior written notice to the Lender, of
any alteration or cancellation of coverage. If the Borrower fails to maintain
such insurance, the Lender may arrange for (at the Borrower's expense and
without any responsibility on the Lender's part for) obtaining the insurance.
Unless the Lender shall otherwise agree with the Borrower in writing, the Lender
shall have the sole right, in the name of the Lender or the Borrower, to file
claims under any insurance policies, to receive and give acquittance for any
payments that may be payable thereunder, and to execute any endorsements,
receipts, releases, assignments, reassignments, or other documents that may be
necessary to effect the collection, compromise, or settlement of any claims
under any such insurance policies.

                           SECTION 5.5. TAXES. The Borrower will pay, when due,
all taxes, assessments, claims, and other charges ("Taxes") lawfully levied or
assessed against the Borrower or the Collateral other than taxes that are being
diligently contested in good faith by the Borrower by appropriate proceedings
promptly instituted and for which an adequate reserve is being maintained by the
Borrower in accordance with GAAP. If any Taxes remain unpaid after the date
fixed for the payment thereof, or if any lien shall be claimed therefor, then,
without notice to the Borrower, but on the Borrower's behalf, the Lender may pay
such Taxes, and the amount thereof shall be included in the Obligations.

                           SECTION 5.6. BORROWER TO DEFEND COLLATERAL AGAINST
CLAIMS; FEES ON COLLATERAL. The Borrower will defend the Collateral against all
claims and demands of all Persons at any time claiming the same or any interest
therein. The Borrower will not permit any notice creating or otherwise relating
to liens on the Collateral or any portion thereof to exist or be on file in any
public office other than Permitted Liens. The Borrower shall promptly pay, when
payable, all transportation, storage, and warehousing charges and license fees,
registration fees, assessments, charges, permit fees, and taxes (municipal,
state, and federal) which may now or hereafter be imposed upon the ownership,
leasing, renting, possession, sale, or use of the Collateral, other than taxes
on or measured by the Lender's income and fees, assessments, charges, and taxes
which are being contested in good faith by appropriate proceedings diligently
conducted and with respect to which adequate reserves are maintained to the
extent required by GAAP.

                            SECTION 5.7. NO CHANGE OF LOCATION, STRUCTURE, OR
IDENTITY. The Borrower will not (a) change the location of its chief executive
office or establish any place of business other than those specified herein or
(b) move or permit the movement of any item of Collateral from the location
specified in the applicable Schedule, except that the Borrower may change its
chief executive office and keep Collateral at other locations within the United
States provided that the Borrower has delivered to the Lender (i) prior written
notice thereof and (ii) duly executed financing statements and other agreements
and instruments (all in form and substance satisfactory to the Lender) necessary
or, in the opinion of the Lender, desirable to perfect and maintain in favor of
the Lender a first priority security interest in the Collateral. Notwithstanding
anything to the contrary in the immediately preceding sentence, the Borrower may
keep any Collateral consisting of motor vehicles or rolling stock at any
location in the United States provided that the Lender's security interest in
any such Collateral is conspicuously marked on the certificate of title thereof
and the Borrower has complied with the provisions of Section 5.9.

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                           SECTION 5.8. USE OF COLLATERAL; LICENSES; REPAIR. The
Collateral shall be operated by competent, qualified personnel in connection
with the Borrower's business purposes, for the purpose for which the Collateral
was designed and in accordance with applicable operating instructions, laws, and
government regulations, and the Borrower shall use every reasonable precaution
to prevent loss or damage to the Collateral from fire and other hazards. The
Collateral shall not be used or operated for personal, family, or household
purposes. The Borrower shall procure and maintain in effect all orders,
licenses, certificates, permits, approvals, and consents required by federal,
state, or local laws or by any governmental body, agency, or authority in
connection with the delivery, installation, use, and operation of the
Collateral. The Borrower shall keep all of the Equipment in a satisfactory state
of repair and satisfactory operating condition in accordance with industry
standards, ordinary wear and tear excepted, and will make all repairs and
replacements when and where necessary and practical. The Borrower will not waste
or destroy the Equipment or any part thereof, and will not be negligent in the
care or use thereof. The Equipment shall not be annexed or affixed to or become
part of any realty without the Lender's prior written consent.

                           SECTION 5.9. FURTHER ASSURANCES. The Borrower will,
promptly upon request by the Lender, execute and deliver or use its reasonable
best efforts to obtain any document required by the Lender (including, without
limitation, warehouseman or processor disclaimers, mortgagee waivers, landlord
disclaimers, or subordination agreements with respect to the Obligations and the
Collateral), give any notices, execute and file any financing statements,
mortgages, or other documents (all in form and substance satisfactory to the
Lender), mark any chattel paper, deliver any chattel paper or instruments to the
Lender, and take any other actions that are necessary or, in the opinion of the
Lender, desirable to perfect or continue the perfection and the first priority
of the Lender's security interest in the Collateral, to protect the Collateral
against the rights, claims, or interests of any Persons, or to effect the
purposes of this Agreement. The Borrower hereby authorizes the Lender to file
one or more financing or continuation statements, and amendments thereto,
relating to all or any part of the Collateral without the signature of the
Borrower where permitted by law. A carbon, photographic, or other reproduction
of this Agreement or any financing statement covering the Collateral or any part
thereof shall be sufficient as a financing statement where permitted by law. To
the extent required under this Agreement, the Borrower will pay all costs
incurred in connection with any of the foregoing.

                           SECTION 5.10. NO DISPOSITION OF COLLATERAL. The
Borrower will not in any way hypothecate or create or permit to exist any lien,
security interest, charge, or encumbrance on or other interest in any of the
Collateral, except for the lien and security interest granted hereby and
Permitted Liens which are junior to the lien and security interest of the
Lender, and the Borrower will not, without the prior written consent of Lender
sell, transfer, assign, pledge, collaterally assign, exchange, or otherwise
dispose of any of the Collateral. In the event the Collateral, or any part
thereof, is sold, transferred, assigned, exchanged, or otherwise disposed of in
violation of these provisions, the security interest of the Lender shall
continue in such Collateral or part thereof notwithstanding such sale, transfer,
assignment, exchange, or other disposition, and the Borrower will hold the
proceeds thereof in a separate account for the benefit of the Lender. Following
such a sale, the Borrower will transfer such proceeds to the Lender in kind.

                           SECTION 5.11. NO LIMITATION ON LENDER'S RIGHTS. The
Borrower will not enter into any contractual obligations which may restrict or
inhibit the Lender's rights or ability to sell or otherwise dispose of the
Collateral or any part thereof.

                           SECTION 5.12. PROTECTION OF COLLATERAL. Upon notice
to the Borrower (provided that if an Event of Default has occurred and is
continuing the Lender need not give any notice), the Lender shall have the right
at any time to make any payments and do any other acts the Lender may deem
necessary to protect its security interests in the Collateral, including,
without limitation, the rights to satisfy, purchase, contest, or compromise any
encumbrance, charge, or lien which, in the reasonable judgment of the Lender,
appears to be prior to or superior to the security interests granted hereunder,
and appear in, and defend any action or proceeding purporting to affect its
security interests in, or the value of, any of the Collateral. The Borrower
hereby agrees to reimburse the Lender for all payments made and expenses
incurred under this Agreement including fees, expenses, and disbursements of
attorneys and paralegals (including the allocated costs of in-house counsel)
acting for the

                                       8
<PAGE>

Lender, including any of the foregoing payments under, or acts taken to protect
its security interests in, any of the Collateral, which amounts shall be secured
under this Agreement, and agrees it shall be bound by any payment made or act
taken by the Lender hereunder absent the Lender's gross negligence or willful
misconduct. The Lender shall have no obligation to make any of the foregoing
payments or perform any of the foregoing acts.

                           SECTION 5.13. DELIVERY OF ITEMS. The Borrower will
(a) promptly (but in no event later than one Business Day) after its receipt
thereof, deliver to the Lender any documents or certificates of title issued
with respect to any property included in the Collateral, and any promissory
notes, letters of credit or instruments related to or otherwise in connection
with any property included in the Collateral, which in any such case come into
the possession of the Borrower, or shall cause the issuer thereof to deliver any
of the same directly to the Lender, in each case with any necessary endorsements
in favor of the Lender and (b) deliver to the Lender as soon as available copies
of any and all press releases and other similar communications issued by the
Borrower.

                           SECTION 5.14. SOLVENCY. The Borrower shall be and
remain Solvent at all times.

                           SECTION 5.15. FUNDAMENTAL CHANGES. The Borrower
shall not (a) amend or modify its name, unless the Borrower delivers to the
Lender thirty days prior to any such proposed amendment or modification written
notice of such amendment or modification and within ten days before such
amendment or modification delivers executed Uniform Commercial Code financing
statements (in form and substance satisfactory to the Lender) or (b) merge or
consolidate with any other entity or make any material change in its capital
structure, in each case without the Lender's prior written consent which shall
not be unreasonably withheld except that such consent of the Lender shall not be
required in the event that the Borrower makes an initial public offering of its
capital stock in an underwritten public offering.

                           SECTION 5.16. ADDITIONAL REQUIREMENTS. The Borrower
shall take all such further actions and execute all such further documents and
instruments as the Lender may reasonably request.

                  SECTION 6. FINANCIAL STATEMENTS. Until the payment and
satisfaction in full of all Obligations, the Borrower shall deliver to the
Lender the following financial information:

                           SECTION 6.1. ANNUAL FINANCIAL STATEMENTS. As soon as
available, but not later than 120 days after the end of each fiscal year of the
Borrower and its consolidated subsidiaries, the consolidated balance sheet,
income statement, and statements of cash flows and shareholders equity for the
Borrower and its consolidated subsidiaries (the "Financial Statements") for such
year, reported on by independent certified public accountants without an adverse
qualification; and

                           SECTION 6.2. QUARTERLY FINANCIAL STATEMENTS. As soon
as available, but not later than 60 days after the end of each of the first
three fiscal quarters in any fiscal year of the Borrower and its consolidated
subsidiaries, the Financial Statements for such fiscal quarter, together with a
certification duly executed by a responsible officer of the Borrower that such
Financial Statements have been prepared in accordance with GAAP and are fairly
stated in all material respects (subject to normal year-end audit adjustments).

                  SECTION 7. EVENTS OF DEFAULT. The occurrence of any of the
following events shall constitute an Event of Default hereunder:

                           (a) the Borrower shall fail to pay within five days
of when due any amount required to be paid by the Borrower under or in
connection with any Note and this Agreement;

                           (b) any representation or warranty made or deemed
made by the Borrower under or in connection with any Loan Document or any
Financial Statement shall prove to have been false or incorrect in any material
respect when made;

                           (c) the Borrower shall fail to perform or observe (i)
any of the terms, covenants or agreements contained in Sections 5.4, 5.7, 5.10,
5.14, or 5.15 hereof or (ii) any other term, covenant, or agreement

                                       9
<PAGE>

contained in any Loan Document (other than the other Events of Default
specified in this Section 7) and such failure remains unremedied for the
earlier of fifteen days from (A) the date on which the Lender has given the
Borrower written notice of such failure and (B) the date on which the
Borrower knew or should have known of such failure;

                           (d) dissolution, liquidation, winding up, or
cessation of the Borrower's business, failure of the Borrower generally to pay
its debts as they mature, admission in writing by the Borrower of its inability
generally to pay its debts as they mature, or calling of a meeting of the
Borrower's creditors for purposes of compromising any of the Borrower's debts;

                           (e) the commencement by or against the Borrower of
any bankruptcy, insolvency, arrangement, reorganization, receivership, or
similar proceedings under any federal or state law and, in the case of any such
involuntary proceeding, such proceeding remains undismissed or unstayed for
sixty days following the commencement thereof, or any action by the Borrower is
taken authorizing any such proceedings;

                           (f) an assignment for the benefit of creditors is
made by the Borrower, whether voluntary or involuntary, the appointment of a
trustee, custodian, receiver, or similar official for the Borrower or for any
substantial property of the Borrower, or any action by the Borrower authorizing
any such proceeding;

                           (g) the Borrower shall default in (i) the payment of
principal or interest on any indebtedness in excess of $50,000 (other than the
Obligations) after any and all applicable grace periods, if any, provided in the
instrument or agreement under which such indebtedness was created shall have
lapsed; or (ii) the observance or performance of any other agreement or
condition relating to any such indebtedness or contained in any instrument or
agreement relating thereto, or any other event shall occur or condition exist,
the effect of which default or other event or condition is to cause, or to
permit the holder or holders of such indebtedness to cause, with the giving of
notice if required, such indebtedness to become due prior to its stated
maturity;

                           (h) the Borrower suffers or sustains a Material
Adverse Change;

                           (i) any tax lien, other than a Permitted Lien, is
filed of record against the Borrower and is not bonded or discharged within five
Business Days;

                           (j) any judgment which has had or could reasonably
be expected to have a Material Adverse Effect on the Borrower and such judgment
shall not be stayed, vacated, bonded, or discharged within sixty days;

                           (k) any material covenant, agreement, or obligation,
as determined in the sole discretion of the Lender, made by the Borrower and
contained in or evidenced by any of the Loan Documents shall cease to be
enforceable, or shall be determined to be unenforceable, in accordance with its
terms; the Borrower shall deny or disaffirm the Obligations under any of the
Loan Documents or any liens granted in connection therewith; or any liens
granted on any of the Collateral in favor of the Lender shall be determined to
be void, voidable, or invalid, or shall not be given the priority contemplated
by this Agreement; or

                           (l) except in the case that Borrower completes an
initial public offering of capital stock in an underwritten public offering,
there is a change in more than 35% of the ownership of any equity interests of
the Borrower on the date hereof or more than 35% of such interests become
subject to any contractual, judicial, or statutory lien, charge, security
interest, or encumbrance.

                  SECTION 8. REMEDIES. If any Event of Default shall have
occurred and be continuing:

                           (a) The Lender may, without prejudice to any of its
other rights under any Loan Document or Applicable Law, declare all Obligations
to be immediately due and payable (except with respect to any Event of Default
set forth in Section 7(f) hereof, in which case all Obligations shall
automatically become

                                       10
<PAGE>

immediately due and payable without necessity of any
declaration) without presentment, representation, demand of payment, or protest,
which are hereby expressly waived.

                           (b) The Lender may take possession of the Collateral
and, for that purpose may enter, with the aid and assistance of any person or
persons, any premises where the Collateral or any part hereof is, or may be
placed, and remove the same.

                           (c) The obligation of the Lender, if any, to make
additional Loans or financial accommodations of any kind to the Borrower shall
immediately terminate.

                           (d) The Lender may exercise in respect of the
Collateral, in addition to other rights and remedies provided for herein (or in
any Loan Document) or otherwise available to it, all the rights and remedies of
a secured party under the applicable Uniform Commercial Code (the "Code")
whether or not the Code applies to the affected Collateral and also may (i)
require the Borrower to, and the Borrower hereby agrees that it will at its
expense and upon request of the Lender forthwith, assemble all or part of the
Collateral as directed by the Lender and make it available to the Lender at a
place to be designated by the Lender that is reasonably convenient to both
parties and (ii) without notice except as specified below, sell the Collateral
or any part thereof in one or more parcels at public or private sale, at any of
the Lender's offices or elsewhere, for cash, on credit, or for future delivery,
and upon such other terms as the Lender may deem commercially reasonable. The
Borrower agrees that, to the extent notice of sale shall be required by law, at
least ten days' notice to the Borrower of the time and place of any public sale
or the time after which any private sale is to be made shall constitute
reasonable notification. The Lender shall not be obligated to make any sale of
Collateral regardless of notice of sale having been given. The Lender may
adjourn any public or private sale from time to time by announcement at the time
and place fixed therefor, and such sale may, without further notice, be made at
the time and place to which it was so adjourned.

                           (e) All cash proceeds received by the Lender in
respect of any sale of, collection from, or other realization upon all or any
part of the Collateral may, in the discretion of the Lender, be held by the
Lender as collateral for, or then or at any time thereafter applied in whole or
in part by the Lender against, all or any part of the Obligations in such order
as the Lender shall elect. Any surplus of such cash or cash proceeds held by the
Lender and remaining after the full and final payment of all the Obligations
shall be paid over to the Borrower or to such other Person to which the Lender
may be required under applicable law, or directed by a court of competent
jurisdiction, to make payment of such surplus.

                  SECTION 9. MISCELLANEOUS PROVISIONS.

                           SECTION 9.1. NOTICES. Except as otherwise provided
herein, all notices, approvals, consents, correspondence, or other
communications required or desired to be given hereunder shall be given in
writing and shall be delivered by overnight courier, hand delivery, or certified
or registered mail, postage prepaid, if to the Lender, then to Transamerica
Technology Finance Division, 76 Batterson Park Road, Farmington, Connecticut
06032, Attention: Legal Department, with a copy to the Lender at Riverway II,
West Office Tower, 9399 West Higgins Road, Rosemont, Illinois 60018, Attention:
Legal Department, and if to the Borrower, then to One Kendall Square, Building
600, Cambridge, Massachusetts 02139, Attention: Loan Administration, or such
other address as shall be designated by the Borrower or the Lender to the other
party in accordance herewith. All such notices and correspondence shall be
effective when received.

                           SECTION 9.2. HEADINGS. The headings in this Agreement
are for purposes of reference only and shall not affect the meaning or
construction of any provision of this Agreement.

                           SECTION 9.3. ASSIGNMENTS. The Borrower shall not
have the right to assign any Note or this Agreement or any interest therein
unless the Lender shall have given the Borrower prior written consent and the
Borrower and its assignee shall have delivered assignment documentation in form
and substance satisfactory to the Lender in its sole discretion. The Lender may
assign its rights and delegate its obligations under any Note or this Agreement.

                                       11
<PAGE>

                           SECTION 9.4. AMENDMENTS, WAIVERS, AND CONSENTS. Any
amendment or waiver of any provision of this Agreement and any consent to any
departure by the Borrower from any provision of this Agreement shall be
effective only by a writing signed by the Lender and the Borrower and shall bind
and benefit the Borrower and the Lender and their respective successors and
assigns, subject, in the case of the Borrower, to the first sentence of Section
9.3.

                           SECTION 9.5. INTERPRETATION OF AGREEMENT. Time is of
the essence in each provision of this Agreement of which time is an element. All
terms not defined herein or in a Note shall have the meaning set forth in the
applicable Code, except where the context otherwise requires. To the extent a
term or provision of this Agreement conflicts with any Note, or any term or
provision thereof, and is not dealt with herein with more specificity, this
Agreement shall control with respect to the subject matter of such term or
provision. Acceptance of or acquiescence in a course of performance rendered
under this Agreement shall not be relevant in determining the meaning of this
Agreement even though the accepting or acquiescing party had knowledge of the
nature of the performance and opportunity for objection.

                           SECTION 9.6. CONTINUING SECURITY INTEREST. This
Agreement shall create a continuing security interest in the Collateral and
shall (i) remain in full force and effect until the indefeasible payment in full
of the Obligations, (ii) be binding upon the Borrower and its successors and
assigns and (iii) inure, together with the rights and remedies of the Lender
hereunder, to the benefit of the Lender and its successors, transferees, and
assigns.

                           SECTION 9.7. REINSTATEMENT. To the extent permitted
by law, this Agreement and the rights and powers granted to the Lender hereunder
and under the Loan Documents shall continue to be effective or be reinstated if
at any time any amount received by the Lender in respect of the Obligations is
rescinded or must otherwise be restored or returned by the Lender upon the
insolvency, bankruptcy, dissolution, liquidation, or reorganization of the
Borrower or upon the appointment of any receiver, intervenor, conservator,
trustee, or similar official for the Borrower or any substantial part of its
assets, or otherwise, all as though such payments had not been made.

                           SECTION 9.8. SURVIVAL OF PROVISIONS. All
representations, warranties, and covenants of the Borrower contained herein
shall survive the execution and delivery of this Agreement, and shall terminate
only upon the full and final payment and performance by the Borrower of the
Obligations secured hereby.

                           SECTION 9.9. INDEMNIFICATION. The Borrower agrees to
indemnify and hold harmless the Lender and its directors, officers, agents,
employees, and counsel from and against any and all costs, expenses, claims, or
liability incurred by the Lender or such Person hereunder and under any other
Loan Document or in connection herewith or therewith, unless such claim or
liability shall be due to willful misconduct or gross negligence on the part of
the Lender or such Person.

                           SECTION 9.10. COUNTERPARTS; TELECOPIED SIGNATURES.
This Agreement may be executed in counterparts, each of which when so executed
and delivered shall be an original, but both of which shall together constitute
one and the same instrument. This Agreement and each of the other Loan Documents
and any notices given in connection herewith or therewith may be executed and
delivered by telecopier or other facsimile transmission all with the same force
and effect as if the same was a fully executed and delivered original manual
counterpart.

                           SECTION 9.11. SEVERABILITY. In case any provision in
or obligation under this Agreement or any Note or any other Loan Document shall
be invalid, illegal, or unenforceable in any jurisdiction, the validity,
legality, and enforceability of the remaining provisions or obligations, or of
such provision or obligation in any other jurisdiction, shall not in any way be
affected or impaired thereby.

                           SECTION 9.12. DELAYS; PARTIAL EXERCISE OF REMEDIES.
No delay or omission of the Lender to exercise any right or remedy hereunder,
whether before or after the happening of any Event of Default, shall impair any
such right or shall operate as a waiver thereof or as a waiver of any such Event
of Default. No

                                       12
<PAGE>

single or partial exercise by the Lender of any right or remedy shall
preclude any other or further exercise thereof, or preclude any other right
or remedy.

                           SECTION 9.13. ENTIRE AGREEMENT. The Borrower and the
Lender agree that this Agreement, the Schedule hereto, and the Commitment Letter
are the complete and exclusive statement and agreement between the parties with
respect to the subject matter hereof, superseding all proposals and prior
agreements, oral or written, and all other communications between the parties
with respect to the subject matter hereof. Should there exist any inconsistency
between the terms of the Commitment Letter and this Agreement, the terms of this
Agreement shall prevail.

                           SECTION 9.14. SETOFF. In addition to and not in
limitation of all rights of offset that the Lender may have under Applicable
Law, and whether or not the Lender has made any demand or the Obligations of the
Borrower have matured, the Lender shall have the right to appropriate and apply
to the payment of the Obligations of the Borrower all deposits and other
obligations then or thereafter owing by the Lender to or for the credit or the
account of the Borrower.

                           SECTION 9.15. WAIVER OF JURY TRIAL. THE BORROWER AND
THE LENDER IRREVOCABLY WAIVE ALL RIGHT TO TRIAL BY JURY IN ANY ACTION,
PROCEEDING, OR COUNTERCLAIM ARISING OUT OF OR RELATING TO THIS AGREEMENT, ANY
OTHER LOAN DOCUMENT, OR THE TRANSACTIONS CONTEMPLATED HEREBY OR THEREBY.

                           SECTION 9.16. GOVERNING LAW. THE VALIDITY,
INTERPRETATION, AND ENFORCEMENT OF THIS AGREEMENT SHALL BE GOVERNED BY AND
CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF ILLINOIS WITHOUT GIVING
EFFECT TO THE CONFLICT OF LAW PRINCIPLES THEREOF.

                           SECTION 9.17. VENUE; SERVICE OF PROCESS. ANY LEGAL
ACTION OR PROCEEDING WITH RESPECT TO THIS AGREEMENT OR ANY OTHER LOAN DOCUMENT
MAY BE BROUGHT IN THE COURTS OF THE STATE OF ILLINOIS SITUATED IN COOK COUNTY,
OR OF THE UNITED STATES OF AMERICA FOR THE NORTHERN DISTRICT OF ILLINOIS, AND,
BY EXECUTION AND DELIVERY OF THIS AGREEMENT, THE BORROWER HEREBY ACCEPTS FOR
ITSELF AND IN RESPECT OF ITS PROPERTY, GENERALLY AND UNCONDITIONALLY, THE
JURISDICTION OF THE AFORESAID COURTS. THE BORROWER HEREBY IRREVOCABLY WAIVES, IN
CONNECTION WITH ANY SUCH ACTION OR PROCEEDING ANY OBJECTION, INCLUDING, WITHOUT
LIMITATION, ANY OBJECTION TO THE LAYING OF VENUE OR BASED ON THE GROUNDS OF
FORUM NON CONVENIENS, THAT IT MAY NOW OR HEREAFTER HAVE TO THE BRINGING OF ANY
SUCH ACTION OR PROCEEDING IN SUCH RESPECTIVE JURISDICTIONS. THE BORROWER
IRREVOCABLY CONSENTS TO THE SERVICE OF PROCESS OF ANY OF THE AFOREMENTIONED
COURTS IN ANY SUCH ACTION OR PROCEEDING BY THE MAILING OF COPIES THEREOF BY
REGISTERED OR CERTIFIED MAIL, POSTAGE PREPAID, TO THE BORROWER AT THE ADDRESS
FOR IT SPECIFIED IN SECTION 9.1 HEREOF. NOTHING HEREIN SHALL AFFECT THE RIGHT OF
THE LENDER TO SERVE PROCESS IN ANY OTHER MANNER PERMITTED BY LAW OR TO COMMENCE
LEGAL PROCEEDINGS OR OTHERWISE PROCEED AGAINST THE BORROWER IN ANY OTHER
JURISDICTION, SUBJECT IN EACH INSTANCE TO THE PROVISIONS HEREOF WITH RESPECT TO
RIGHTS AND REMEDIES.

                                       13
<PAGE>

                  IN WITNESS WHEREOF, the undersigned Borrower has caused this
Agreement to be duly executed and delivered by its proper and duly authorized
officer as of the date first set forth above.

                                           DYAX CORPORATION

                                           By: /s/ Stephen S. Galliker
                                               --------------------------------
                                               Name: Stephen S. Galliker
                                               Title: EVP, CFO
                                           Federal Tax ID No.: 04-3053198

Accepted as of the
27th day of June, 2000

TRANSAMERICA BUSINESS CREDIT CORPORATION

By: /s/ Keith J. Mason
    ------------------------------------
    Name: Keith J. Mason
    Title: SVP Credit

Form16

                                       14
<PAGE>

                                   SCHEDULE A

                                       TO

                           LOAN AND SECURITY AGREEMENT

Collateral Locations (Section 4.6):

Model and Serial Numbers (Section 4.10):

Litigation (Section 4.3): Pieczenik sued Dyax in December 1999 and January 2000
for patent infringement under two U.S. Patents (U.S. Patent Nos. 5,866,363 and
4,528,266). Dyax has moved for dismissal of the suit on several grounds and the
motion to dismiss was heard on April 26, 2000.

                                       15

<PAGE>

                                                                       EXHIBIT A

February 8, 2000

Peter R. Rock
Corporate Controller
Dyax Corporation
One Kendall Square
Building 600
Cambridge, MA  02139

Dear Peter:

Transamerica Business Credit Corporation - Technology Finance Division
("Lender") is pleased to offer financing for the Equipment described in this
letter (this "Commitment") to Dyax Corporation ("Borrower"). Except as described
in a commitment letter dated December 17, 1997 (the "Prior Commitment"), this
Commitment supersedes all prior correspondence, proposals, and oral or other
communications relating to financing arrangements between Borrower and Lender.

The outline of this offer is as follows:

<TABLE>
<S>                              <C>
LENDER:                            Transamerica  Business Credit Corporation -
                                   Technology Finance Division and/or its
                                   affiliates, successors or assigns.

BORROWER:                          Dyax Corporation

AMOUNT OF LOANS:                   Not to exceed $2,000,000 in the aggregate
                                   (in addition to the Prior Commitment). All
                                   available funds under the Prior Commitment
                                   must be completely drawn down by Borrower
                                   prior to any initial funding under this
                                   Commitment.

USE OF PROCEEDS:                   Proceeds of these Loans will be used to
                                   finance various laboratory, office,
                                   computer hardware and software equipment
                                   including related soft costs (not to exceed
                                   15% of Commitment) (the "Equipment"). All
                                   Equipment subject to Lender approval prior to
                                   funding.

COLLATERAL:                        Lender will require a perfected first
                                   priority security interest in all Equipment
                                   financed with the Loans, including but not
                                   limited to all additions, accessions,
                                   improvements, replacements and attachments
                                   thereto and proceeds (including insurance
                                   proceeds) thereof (the "Collateral").

LOCATION OF COLLATERAL:            Cambridge, MA

EXPECTED DRAW-DOWN SCHEDULE:       A minimum of $500,000 will be drawn on or
                                   before April 15, 2000, and the remaining
                                   availability will be drawn on or before
                                   December 15, 2000.

DRAW-DOWN EXPIRATION:              No Loans will be funded after December 15,
                                   2000.

<PAGE>

LOAN TERM:                         Each Loan Term will commence upon
                                   delivery of the Equipment or upon each
                                   delivery of items of Equipment having an
                                   aggregate cost of not less than $50,000, and
                                   will continue through 42 months from the
                                   first day of the month next following or
                                   coincident with commencement of that Loan
                                   Term.

PAYMENT TERMS:                     Monthly Payments equal to 2.76% of original
                                   principal amount of each Loan will be
                                   payable monthly in advance. The first and
                                   last Monthly Payments will be due and payable
                                   on or before commencement of each Loan Term.

ADJUSTMENT TO                      Lender reserves the right to increase the
PAYMENT TERMS:                     rate set forth  above as of the date
                                   each Loan Term commences commensurate to the
                                   change in the weekly average of the
                                   interest rates of four-year U.S. Treasury
                                   Securities (as published in the WALL STREET
                                   JOURNAL) from the week ending December 3,
                                   1999 (6.08%) to the week preceding the
                                   commencement of that Loan Term. As of the
                                   date each Loan Term commences, the Monthly
                                   Payment will be fixed for that entire Loan
                                   Term. A schedule of the actual Monthly
                                   Payments will be provided by the Lender
                                   following commencement of each Loan Term.

BALLOON PAYMENT:                   At the end of each Loan Term, the
                                   Borrower will be obligated to make one final
                                   Balloon Payment equal to 10% of the original
                                   principal amount of each Loan, plus any other
                                   amounts then due and owing to Lender.

INTERIM PAYMENT:                   An Interim Payment will accrue from
                                   the date each Loan Term commences until the
                                   next following first day of a month (unless
                                   the Loan Term commences on the first day of a
                                   month). The Interim Payment will be
                                   calculated at the daily equivalent of the
                                   currently adjusted Monthly Payment.

INSURANCE:                         Prior to any delivery of Equipment, the
                                   Borrower will furnish confirmation of
                                   insurance acceptable to the Lender covering
                                   the Collateral including primary, all risk,
                                   physical damage, property damage and bodily
                                   injury with appropriate loss payee and
                                   additional insured endorsements in favor of
                                   the Lender.

CONDITIONS PRECEDENT               Each Loan will be subject to the following:
TO LENDING:                        1. No material adverse change in the
                                      financial condition, operations or
                                      prospects of the Borrower prior to
                                      funding. The Lender reserves the right
                                      to rescind any unused portion of its
                                      commitment in the event of a material
                                      adverse change in the financial condition,
                                      operation or prospects of the Borrower.

                                   2. Completion of the documentation and
                                      final terms of the proposed financing
                                      satisfactory to Lender and Lender's
                                      counsel.

                                   3. Results of all due diligence, including
                                      lien, judgment and tax search and other
                                      matters Lender may request shall be
                                      satisfactory to Lender and Lender's
                                      counsel.

                                       2

<PAGE>

                                   4. Receipt by Lender of duly executed loan
                                      documentation in form and substance
                                      satisfactory to Lender and its counsel.

                                   5. Lender shall receive a valid and
                                      perfected first priority lien and
                                      security interest in the Collateral and
                                      Lender shall have received satisfactory
                                      evidence that there are no liens on the
                                      Collateral except as expressly permitted
                                      herein.

ADDITIONAL                         There will be no actual or threatened
COVENANTS:                         conflict with, or violation of (1) any
                                   regulatory statute, (2) standard or rule
                                   relating to the Borrower, (3) its present or
                                   future operations or (4) the Collateral.

                                   Borrower will be required to provide
                                   quarterly financial information. All
                                   information supplied by the Borrower will be
                                   correct and will not omit any statement
                                   necessary to make the information supplied
                                   not be misleading. There will be no material
                                   breach of the representations and warranties
                                   of the Borrower in the loan.

EXPENSES:                          All costs and expenses incurred by the
                                   Lender in connection with the underwriting
                                   and closing of the Loans will be paid by the
                                   Borrower whether or not any Loans are
                                   consummated and funds are advanced by the
                                   Lender. Borrower will be billed for Expenses.

LAW:                               This letter and the proposed Loan are
                                   intended to be governed by and construed in
                                   accordance with Illinois law without regard
                                   to its conflict of law provisions.

INDEMNITY:                         Borrower agrees to indemnify and to hold
                                   harmless Lender, and its officers, directors
                                   and employees against all claims, damages,
                                   liabilities and expenses which may be
                                   incurred by or asserted against any such
                                   person in connection with or arising out of
                                   this letter and the transactions contemplated
                                   hereby, other than claims, damages,
                                   liability, and expense resulting from such
                                   person's gross negligence or willful
                                   misconduct.

CONFIDENTIALITY:                   This letter is delivered to you with the
                                   understanding that neither it nor its
                                   substance shall be disclosed publicly or
                                   privately to any third person except those
                                   who are in a confidential relationship to you
                                   (such as your legal counsel and accountants),
                                   or where the same is required by law and then
                                   only on the basis that it not be further
                                   disclosed, which conditions Borrower and its
                                   agents agree to be bound by upon acceptance
                                   of this letter.

                                   Without limiting the generality of the
                                   foregoing, none of such persons shall use or
                                   refer to Lender or to any affiliate name in
                                   any disclosures made in connection with any
                                   of the transactions without Lender's prior
                                   written consent.

                                       3

<PAGE>

                                   Upon completion of the initial takedown by
                                   Borrower, the Borrower will no longer be
                                   required to obtain Lender's prior written
                                   consent to disclose the transaction
                                   contemplated hereby. In addition, the
                                   Borrower agrees to provide camera ready
                                   artwork of typestyles and logos of the
                                   Borrower for use in promotional material
                                   by the Lender.

CONDITIONS OF ACCEPTANCE:          This Commitment Letter is intended to be a
                                   summary of the most important elements
                                   of the agreement to enter into a loan
                                   transaction with Borrower, and it is subject
                                   to all requirements and conditions contained
                                   in Loan documentation proposed by Lender or
                                   its counsel in the course of closing the
                                   Loans described herein. Not every provision
                                   that imposes duties, obligations, burdens, or
                                   limitations on Borrower is contained  herein,
                                   but shall be contained in the final Loan
                                   documentation satisfactory to Lender and its
                                   counsel.

                                   EACH OF THE PARTIES HERETO IRREVOCABLY AND
                                   UNCONDITIONALLY WAIVES ALL RIGHT TO TRIAL BY
                                   JURY IN ANY SUIT, ACTION, PROCEEDING OR
                                   COUNTERCLAIM ARISING OUT OF OR RELATED TO
                                   THIS LETTER OR THE TRANSACTION DESCRIBED IN
                                   THIS LETTER.

APPLICATION FEE:                   The $20,000 Application Fee previously
                                   paid by the Borrower will be first applied to
                                   the reasonable costs and expenses of the
                                   Lender in connection with the transaction,
                                   and any remainder shall be applied pro rata
                                   (based on the amount of each funding to the
                                   total amount of this Commitment) to the
                                   second month's payment due under the Loan.

COMMITMENT EXPIRATION:             This Commitment shall expire on February 15,
                                   2000 unless prior thereto either extended in
                                   writing by the Lender or accepted as
                                   provided below by the Borrower.
</TABLE>

Should you have any questions, please call me. If you wish to accept this
Commitment, please so indicate by signing and returning the enclosed duplicate
copy of this letter to me by February 15, 2000.

                                          Yours truly,

                                          TRANSAMERICA BUSINESS CREDIT
                                          CORP - TECHNOLOGY FINANCE
                                          DIVISION

                                          By_______________________________
                                            Gerald A. Michaud
                                            Senior Vice President - Marketing

Accepted this __ day of February, 2000.

DYAX CORPORATION

By______________________________
Name:
Title:

                                       4
<PAGE>

                                                                       EXHIBIT B

                           COLLATERAL ACCESS AGREEMENT
                    TRANSAMERICA BUSINESS CREDIT CORPORATION
                        9399 West Higgins Road, Suite 600
                            Rosemont, Illinois 60018

                                                      ____________________, 2000

_____________________________________

_____________________________________

_____________________________________

         Re:      DYAX CORP.

Ladies and Gentlemen:

                  We have been asked by DYAX CORP., a Delaware corporation (the
"Company") to finance certain equipment (the "Equipment"), which will be located
at the address identified on Schedule A (the "Premises"). The obligations of the
Company to us will be secured by, among other things, the Equipment. We
understand that the Company leases the Premises from you pursuant to a lease or
is the owner of the Premises, which is subject to a lien in favor of you
pursuant to a mortgage (such lease or mortgage being referred to as the
"Agreement").

                  In connection with the extensions of credit to be made to the
Company, Transamerica Business Credit Corporation, ("Transamerica") will be
making customary Uniform Commercial Code filings on behalf of Transamerica with
respect to the Equipment. In addition, we request your acknowledgment and
cooperation for preserving and enforcing Transamerica's security interests. To
expedite the consummation of the proposed financing, we would appreciate your
execution of this letter.

                  To induce Transamerica to finance the Equipment, and for other
good and valuable consideration, you confirm and acknowledge the following
matters to us:

                  1. You will allow us, or our auditors or other designees,
reasonable access to the Premises to inspect the Equipment from time to time. In
addition, upon our request, you will grant us and our designees access to the
Premises for 90 days at reasonable times to show the Equipment to potential
purchasers and to remove the Equipment from the Premises.

                  2. In the event that the Company defaults in its obligations
under the Agreement or you desire or elect to terminate or exercise remedies
under the Agreement for any reason, including a default by the Company under the
Agreement, you will notify us in writing of this fact prior to your terminating
or exercising remedies under the Agreement and retaking possession of the
Premises. You hereby confirm and acknowledge to us that you do not and will not
have any claim to or lien on any of the Equipment, whether such Equipment
constitutes fixtures or personal property.

                  We would appreciate your confirming to us your agreement to
the foregoing provisions of this letter by signing and returning to us this
letter at our address shown above.

Very truly yours,

TRANSAMERICA BUSINESS CREDIT CORPORATION

By:  ____________________________________
   Name:
   Title:

ACKNOWLEDGED AND AGREED:

By:______________________________________
   Name:
   Title:

<PAGE>

                                   SCHEDULE A

Equipment Locations:

One Kendall Square
Building 600
Cambridge, MA  02139

Form5

<PAGE>

                                                                      EXHIBIT C

                                 PROMISSORY NOTE

                                                            Date: ________, 2000

                  FOR VALUE RECEIVED, the undersigned promises to pay to the
order of Transamerica Business Credit Corporation or its assigns (the "Payee")
at its office located at Riverway II, West Office Tower, 9399 West Higgins Road,
Rosemont, Illinois 60018, or at such other place as the Payee or the holder
hereof may designate in writing, the principal amount of _______ Thousand
Dollars ($_______) received by the undersigned, in lawful money of the United
States and in immediately available funds. This Note shall be payable commencing
with a first installment on the date hereof of ___________ Dollars ($________)
and thereafter in __ consecutive equal monthly installments, commencing _____1,
200_, of ___________________Dollars ($_______) and a final installment payable
on ______ 1, 200_ of ______________ Dollars ($________) [if balloon] together
with the unpaid balance of the Note. No amount of principal paid or prepaid
hereunder may be reborrowed.

                  This Note is one of the Notes referred to in the Master Loan
and Security Agreement dated as of __________, 2000 (as amended, supplemented or
otherwise modified from time to time, the "Agreement"), between the undersigned
and the Payee and is subject and entitled to all provisions and benefits
thereof. Capitalized terms used but not defined herein shall have the meanings
set forth in the Agreement.

                  If any installment of this Note is not paid within five days
after its due date, the undersigned agrees to pay on demand, in addition to the
amount of such installment, an amount equal to 5% of such installment, but only
to the extent permitted by Applicable Law.

                  The undersigned shall have the right to prepay this Note at
any time on or after _______ 1, 200_ on thirty days' prior written notice to the
Payee. On the date of any such prepayment, the undersigned shall pay an amount
equal to the present value of the remaining payments due hereunder discounted at
6% simple interest PER ANNUM, together with all fees and other amounts payable
on the amount so prepaid or in connection therewith to the date of such
prepayment. Any prepayments shall be applied to the installments hereof in the
inverse order of maturity.

                  Upon the maturity of this Note, the entire unpaid principal
amount on this Note, together with all interest, fees and other amounts payable
hereon or in connection herewith, shall be immediately due and payable without
further notice or demand, with interest on all such amounts at a rate not to
exceed the lawful limit, from the date of such maturity or acceleration, as the
case may be, until all such amounts have been paid. Upon the acceleration of the
maturity of this Note in accordance with the terms of the Agreement, the entire
unpaid principal amount on this Note, together with all fees, prepayment fees
and charges in an amount equal to the present value of the remaining payments
due hereunder discounted at 6% simple interest PER ANNUM and other amounts
payable hereon or in connection herewith, shall be immediately due and payable
without further notice or demand, with interest on all such amounts at a rate
not to exceed the lawful limit, from the date of such maturity, default or
acceleration, as the case may be, until all such amounts have been paid.

                  If any payment on this Note becomes payable on a day other
than a Business Day, the maturity thereof shall be extended to the next
succeeding Business Day.

<PAGE>

                                     SAMPLE

                  The undersigned hereby waives diligence, demand, presentment,
protest and notice of any kind, and assents to extensions of the time of
payment, release, surrender or substitution of security, or forbearance or other
indulgence, without notice. The undersigned agrees to pay all amounts under this
Note without offset, deduction, claim, counterclaim, defense or recoupment, all
of which are hereby waived.

                  The Payee, the undersigned and any other parties to the Loan
Documents intend to contract in strict compliance with applicable usury law from
time to time in effect. In furtherance thereof such Persons stipulate and agree
that none of the terms and provisions contained in the Loan Documents shall ever
be construed to create a contract to pay, for the use, forbearance or detention
of money, interest in excess of the maximum amount of interest permitted to be
charged by Applicable Law from time to time in effect. Neither the undersigned
nor any present or future guarantors, endorsers, or other Persons hereafter
becoming liable for payment of any Obligation shall ever be liable for unearned
interest thereon or shall ever be required to pay interest thereon in excess of
the maximum amount that may be lawfully charged under Applicable Law from time
to time in effect, and the provisions of this paragraph shall control over all
other provisions of the Loan Documents which may be in conflict or apparent
conflict herewith. The Payee expressly disavows any intention to charge or
collect excessive unearned interest or finance charges in the event the maturity
of any Obligation is accelerated. If (a) the maturity of any Obligation is
accelerated for any reason, (b) any Obligation is prepaid and as a result any
amounts held to constitute interest are determined to be in excess of the legal
maximum, or (c) the Payee or any other holder of any or all of the Obligations
shall otherwise collect amounts which are determined to constitute interest
which would otherwise increase the interest on any or all of the Obligations to
an amount in excess of that permitted to be charged by Applicable Law then in
effect, then all sums determined to constitute interest in excess of such legal
limit shall, without penalty, be promptly applied to reduce the then outstanding
principal of the related Obligations or, at the Payee's or such holder's option,
promptly returned to the undersigned upon such determination. In determining
whether or not the interest paid or payable, under any specific circumstance,
exceeds the maximum amount permitted under Applicable Law, the Payee and the
undersigned (and any other payors thereof) shall to the greatest extent
permitted under Applicable Law, (i) characterize any non-principal payment as an
expense, fee or premium rather than as interest, (ii) exclude voluntary
prepayments and the effects thereof, and (iii) amortize, prorate, allocate, and
spread the total amount of interest through the entire contemplated term of this
Note in accordance with the amount outstanding from time to time thereunder and
the maximum legal rate of interest from time to time in effect under Applicable
Law in order to lawfully charge the maximum amount of interest permitted under
Applicable Law.

                  This Note may not be changed, modified or terminated orally,
but only by an agreement in writing signed by the undersigned and the Payee or
any holder hereof.

                  The undersigned shall, upon demand, pay to the Payee all costs
and expenses incurred by the Payee (including the fees and disbursements of
counsel and other professionals) in connection with the preparation, execution
and delivery of this Note and all other Loan Documents, and in connection with
the administration, modification and amendment of the Loan Documents, and pay to
the Payee all costs and expenses (including the fees and disbursements of
counsel and other professionals) paid or incurred by the Payee in (A) enforcing
or defending its rights under or in respect of this Note or any of the other
Loan Documents, (B) collecting any of the liabilities by the undersigned to the
Payee or otherwise administering the Loan Documents, (C) foreclosing or
otherwise collecting upon any collateral and (D) obtaining any legal, accounting
or other advice in connection with any of the foregoing.

                  This Note shall be binding upon the successors and assigns of
the undersigned and inure to the benefit of the Payee and its successors,
endorsees and assigns. If any term or provision of this Note shall be held
invalid, illegal or unenforceable, the validity of all other terms and
provisions hereof shall in no way be affected thereby.

                                      -2-

<PAGE>

                                     SAMPLE

This Note is being delivered to Payee by the undersigned to evidence a loan from
Payee to the undersigned which loan is secured by among other things the
equipment described on SCHEDULE A attached hereto.

                  EACH OF THE UNDERSIGNED AND, BY ITS ACCEPTANCE HEREOF, THE
PAYEE HEREBY KNOWINGLY, VOLUNTARILY AND INTENTIONALLY WAIVES (TO THE FULLEST
EXTENT PERMITTED BY APPLICABLE LAW) ANY RIGHT IT MAY HAVE TO A TRIAL BY JURY OF
ANY DISPUTE ARISING UNDER OR RELATING TO THIS NOTE AND AGREES THAT ANY SUCH
DISPUTE SHALL BE TRIED BEFORE A JUDGE SITTING WITHOUT A JURY.

                  THIS NOTE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE
WITH THE LAWS OF THE STATE OF ILLINOIS WITHOUT GIVING EFFECT TO PRINCIPLES OF
CONFLICTS OF LAW.

                                                  DYAX CORPORATION

                                                  By:___________________________
                                                     Name:
                                                     Title:

                                      -3-<PAGE>
                                                                  Exhibits 10.7

                               PURCHASE AGREEMENT

                  THIS AGREEMENT is made as of July __, 2000, by and among
Matrix Pharmaceutical, Inc. (the "Company"), a corporation organized under the
laws of the State of Delaware, with its principal offices at 34700 Campus Drive,
Fremont, California 94555, and the purchaser whose name and address is set forth
on the signature page hereof (the "Purchaser").

                  IN CONSIDERATION of the mutual covenants contained in this
Agreement, the Company and the Purchaser agree as follows:

                  SECTION 1. AUTHORIZATION OF SALE OF THE SHARES. Subject to the
terms and conditions of this Agreement, the Company has authorized the sale of
up to 2,500,000 shares (the "Shares") of common stock, par value $0.01 per share
(the "Common Stock"), of the Company.

                  SECTION 2. AGREEMENT TO SELL AND PURCHASE THE SHARES. At the
Closing (as defined in Section 3), the Company will sell to the Purchaser, and
the Purchaser will buy from the Company, upon the terms and conditions
hereinafter set forth, the number of Shares (at the purchase price) shown below:

<TABLE>
<CAPTION>
                                  Price Per
       Number to Be                Share In                Aggregate
        Purchased                  Dollars                   Price
       ------------               ---------                ---------
<S>                               <C>                      <C>

</TABLE>

                  The Company proposes to enter into this same form of purchase
agreement with certain other investors (the "Other Purchasers") and expects to
complete sales of the Shares to them. The Purchaser and the Other Purchasers are
hereinafter sometimes collectively referred to as the "Purchasers," and this
Agreement and the agreements executed by the Other Purchasers are hereinafter
sometimes collectively referred to as the "Agreements." The term "Placement
Agent" shall mean Banc of America Securities LLC.

                  SECTION 3. DELIVERY OF THE SHARES AT THE CLOSING. The
completion of the purchase and sale of the Shares (the "Closing") shall occur as
soon as practicable and as agreed by the parties hereto following notification
by the Securities and Exchange Commission (the "Commission") to the Company of
the Commission's willingness to declare effective the registration statement to
be filed by the Company pursuant to Section 7.1 hereof (the "Registration
Statement") at a place and time (the "Closing Date") to be agreed upon by the
Company and the Placement Agent. In the absence of any such agreement, the
Closing shall take place at the offices of Stroock & Stroock & Lavan LLP,
counsel to the Placement Agent, in New York, New York at 12:00 p.m. local time
on the third business day after the Company delivers

<PAGE>

written notice to the Placement Agent of receipt of such notification from
the Commission. The Company will promptly notify the Purchasers by facsimile
transmission or otherwise of the date, place and time of the Closing.

                  At the Closing, the Company shall deliver to the Purchaser one
or more stock certificates registered in the name of the Purchaser, or in such
nominee name(s) as designated by the Purchaser in writing, representing the
number of Shares set forth in Section 2 above and bearing an appropriate legend
referring to the fact that the Shares were sold in reliance upon the exemption
from registration under the Securities Act of 1933, as amended (the "Securities
Act") provided by Section 4(2) thereof and Rule 506 thereunder. The Company will
promptly substitute one or more replacement certificates without the legend at
such time as the Registration Statement becomes effective. The name(s) in which
the stock certificates are to be registered are set forth in the Stock
Certificate Questionnaire attached hereto as part of Appendix I. The Company's
obligation to complete the purchase and sale of the Shares and deliver such
stock certificate(s) to the Purchaser at the Closing shall be subject to the
following conditions, any one or more of which may be waived by the Company: (a)
receipt by the Company of same-day funds in the full amount of the purchase
price for the Shares being purchased hereunder; (b) completion of the purchases
and sales under the Agreements with all of the Other Purchasers; and (c) the
accuracy of the representations and warranties made by the Purchasers and the
fulfillment of those undertakings of the Purchasers to be fulfilled prior to the
Closing. The Purchaser's obligation to accept delivery of such stock
certificate(s) and to pay for the Shares evidenced thereby shall be subject to
the following conditions: (a) the Commission has notified the Company of the
Commission's willingness to declare the Registration Statement effective on or
prior to the 60th day after the date such Registration Statement was filed by
the Company; and (b) the accuracy in all material respects of the
representations and warranties made by the Company herein and the fulfillment in
all material respects of those undertakings of the Company to be fulfilled prior
to Closing. The Purchaser's obligations hereunder are expressly not conditioned
on the purchase by any or all of the Other Purchasers of the Shares that they
have agreed to purchase from the Company.

                  SECTION 4. REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE
COMPANY.  The Company hereby represents and warrants to, and covenants with,
the Purchaser as follows:

                  4.1. ORGANIZATION AND QUALIFICATION. The Company is a
corporation duly organized, validly existing and in good standing under the laws
of its jurisdiction of incorporation and the Company is qualified to do business
as a foreign corporation in each jurisdiction in which qualification is
required, except where failure to so qualify would not have a Material Adverse
Effect (as defined herein) on the Company. The Company has one subsidiary,
Matrix Pharmaceutical, Ltd., a corporation organized under the laws of the
United Kingdom (the "Subsidiary"). The Subsidiary (i) carries on no material
business activities, (ii) owns no material assets and (iii) is not a
"significant subsidiary" as defined in Regulation S-X, codified at Title 17,
Part 210 of the Code of Federal Regulations.

                                      -2-
<PAGE>

                  4.2. AUTHORIZED CAPITAL STOCK. Except as disclosed in or
contemplated by the Confidential Private Placement Memorandum dated July 11,
2000 prepared by the Company, including all Exhibits (except Exhibit G),
supplements and amendments thereto (the "Private Placement Memorandum"), the
Company had authorized and outstanding capital stock as set forth under the
heading "Capitalization" in the Private Placement Memorandum as of the date set
forth therein; the issued and outstanding shares of the Company's Common Stock
have been duly authorized and validly issued, are fully paid and nonassessable,
have been issued in compliance with all federal and state securities laws, were
not issued in violation of or subject to any preemptive rights or other rights
to subscribe for or purchase securities, and conform in all material respects to
the description thereof contained in the Private Placement Memorandum. Except as
disclosed in or contemplated by the Private Placement Memorandum, the Company
does not have outstanding any options to purchase, or any preemptive rights or
other rights to subscribe for or to purchase, any securities or obligations
convertible into, or any contracts or commitments to issue or sell, shares of
its capital stock. The description of the Company's stock, stock bonus and other
stock plans or arrangements and the options or other rights granted and
exercised thereunder, set forth in the Private Placement Memorandum accurately
and fairly presents the information required to be shown with respect to such
plans, arrangements, options and rights.

                  4.3. ISSUANCE, SALE AND DELIVERY OF THE SHARES. The Shares
have been duly authorized and, when issued, delivered and paid for in the manner
set forth in this Agreement, will be duly authorized, validly issued, fully paid
and nonassessable, and will conform in all material respects to the description
thereof set forth in the Private Placement Memorandum. No preemptive rights or
other rights to subscribe for or purchase exist with respect to the issuance and
sale of the Shares by the Company pursuant to this Agreement. No stockholder of
the Company has any right (which has not been waived or has not expired by
reason of lapse of time following notification of the Company's intent to file
the Registration Statement) to require the Company to register the sale of any
shares owned by such stockholder under the Securities Act in the Registration
Statement. No further approval or authority of the stockholders or the Board of
Directors of the Company will be required for the issuance and sale of the
Shares to be sold by the Company as contemplated herein.

                  4.4. DUE EXECUTION, DELIVERY AND PERFORMANCE OF THE
AGREEMENTS. The Company has full legal right, corporate power and authority to
enter into the Agreements and perform the transactions contemplated hereby. The
Agreements have been duly authorized, executed and delivered by the Company. The
making and performance of the Agreements by the Company and the consummation of
the transactions herein contemplated will not violate any provision of the
organizational documents of the Company and will not result in the creation of
any lien, charge, security interest or encumbrance upon any assets of the
Company pursuant to the terms or provisions of, or will not conflict with,
result in the breach or violation of, or constitute, either by itself or upon
notice or the passage of time or both, a default under any agreement, mortgage,
deed of trust, lease, franchise, license, indenture, permit or other instrument
to which the Company is a party or by which the Company or its properties may be
bound or affected and in each case which would have a material adverse effect on
the condition

                                      -3-
<PAGE>

(financial or otherwise), properties, business, prospects or results of
operations of the Company (a "Material Adverse Effect") or, to the Company's
knowledge, any statute or any authorization, judgment, decree, order, rule or
regulation of any court or any regulatory body, administrative agency or
other governmental body applicable to the Company or its properties. No
consent, approval, authorization or other order of any court, regulatory
body, administrative agency or other governmental body is required for the
execution and delivery of this Agreement or the consummation of the
transactions contemplated by this Agreement, except for compliance with the
Blue Sky laws and federal securities laws applicable to the offering of the
Shares. Upon their execution and delivery, and assuming the valid execution
thereof by the respective Purchasers, the Agreements will constitute valid
and binding obligations of the Company, enforceable in accordance with their
respective terms, except as enforceability may be limited by applicable
bankruptcy, insolvency, reorganization, moratorium or similar laws affecting
creditors' and contracting parties' rights generally and except as
enforceability may be subject to general principles of equity (regardless of
whether such enforceability is considered in a proceeding in equity or at
law) and except as the indemnification agreements of the Company in Section
7.3 hereof may be legally unenforceable.

                  4.5. ACCOUNTANTS. Ernst & Young LLP have expressed their
opinion with respect to the consolidated financial statements to be incorporated
by reference from the Company's Annual Report on Form 10-K for the fiscal year
ended December 31, 1999 into the Registration Statement and the Prospectus which
forms a part thereof, are independent accountants as required by the Securities
Act and the rules and regulations promulgated thereunder (the "Rules and
Regulations").

                  4.6. NO DEFAULTS. Except as to defaults, violations and
breaches which individually or in the aggregate would not be material to the
Company, the Company is not in violation or default of any provision of its
certificate of incorporation or bylaws, or other organizational documents, or in
breach of or default with respect to any provision of any agreement, judgment,
decree, order, mortgage, deed of trust, lease, franchise, license, indenture,
permit or other instrument to which it is a party or by which it or any of its
properties are bound; and there does not exist any state of fact which, with
notice or lapse of time or both, would constitute an event of default on the
part of the Company as defined in such documents, except such defaults which
individually or in the aggregate would not be material to the Company.

                  4.7. CONTRACTS. The contracts described in the Private
Placement Memorandum as being in effect on the date hereof that are material to
the Company, are in full force and effect on the date hereof; and the Company is
not, nor to the Company's knowledge is any other party, in breach of or default
under any of such contracts which would have a Material Adverse Effect.

                  4.8. NO ACTIONS. There are no legal or governmental actions,
suits or proceedings pending or, to the Company's knowledge, threatened to which
the Company is or may be a part or of which property owned or leased by the
Company is or may be the subject, or related to environmental or discrimination
matters, which actions, suits or proceedings, individually or in the aggregate,
might prevent or might reasonably be expected to materially and adversely affect

                                      -4-
<PAGE>

the transactions contemplated by this Agreement or result in a material
adverse change in the condition (financial or otherwise), properties,
business, prospects or results of operations of the Company (a "Material
Adverse Change"); and no labor disturbance by the employees of the Company
exists or, to the Company's knowledge, is imminent which might reasonably be
expected to have a Material Adverse Effect. The Company is not a party to or
subject to the provisions of any material injunction, judgment, decree or
order of any court, regulatory body administrative agency or other
governmental body.

                  4.9. PROPERTIES. The Company has good and marketable title to
all the properties and assets reflected as owned by it in the consolidated
financial statements included in the Private Placement Memorandum, subject to no
lien, mortgage, pledge, charge or encumbrance of any kind except (i) those, if
any, reflected in such consolidated financial statements (including the notes
thereto), or (ii) those which are not material in amount and do not adversely
affect the use made and proposed to be made of such property by the Company. The
Company holds its leased properties under valid and binding leases, with such
exceptions as are not materially significant in relation to its business. Except
as disclosed in the Private Placement Memorandum, the Company owns or leases all
such properties as are necessary to its operations as now conducted.

                  4.10. NO MATERIAL CHANGE. Since March 31, 2000 and except as
specifically contemplated by the Private Placement Memorandum, (i) the Company
has not incurred any material liabilities or obligations, indirect, or
contingent, or entered into any material verbal or written agreement or other
transaction which is not in the ordinary course of business or which could
reasonably be expected to result in a material reduction in the future earnings
of the Company; (ii) the Company has not sustained any material loss or
interference with its businesses or properties from fire, flood, windstorm,
accident or other calamity not covered by insurance; (iii) the Company has not
paid or declared any dividends or other distributions with respect to its
capital stock and the Company is not in default in the payment of principal or
interest on any outstanding debt obligations; (iv) there has not been any change
in the capital stock of the Company other than the sale of the Shares hereunder
and shares or options issued pursuant to employee equity incentive plans or
purchase plans approved by the Company's Board of Directors, or indebtedness
material to the Company (other than in the ordinary course of business); and (v)
there has not been a Material Adverse Change.

                  4.11. INTELLECTUAL PROPERTY. Except as specifically
contemplated by the Private Placement Memorandum, (i) the Company owns or has
obtained valid and enforceable licenses or options for the inventions, patent
applications, patents, trademarks (both registered and unregistered),
tradenames, copyrights and trade secrets necessary for the conduct of the
Company's business as currently

                                      -5-
<PAGE>

conducted and as the Private Placement Memorandum indicates the Company
contemplates conducting (collectively, the "Intellectual Property"); and (ii)
to the Company's knowledge (for each of the following subsections (A) through
(E)): (A) there are no third parties who have any ownership rights to any
Intellectual Property that is owned by, or has been licensed to, the Company
for the product indications described in the Private Placement Memorandum
that would preclude the Company from conducting its business as currently
conducted and as the Private Placement Memorandum indicates the Company
contemplates conducting; (B) there are currently no sales of any products
that would constitute an infringement by third parties of any Intellectual
Property owned, licensed or optioned by the Company; (C) there is no pending
or threatened action, suit, proceeding or claim by others challenging the
rights of the Company in or to any Intellectual Property owned, licensed or
optioned by the Company, other than non-material claims; (D) there is no
pending or threatened action, suit, proceeding or claim by others challenging
the validity or scope of any Intellectual Property owned, licensed or
optioned by the Company, other than non-material claims; and (E) there is no
pending or threatened action, suit, proceeding or claim by others that the
Company infringes or otherwise violate any patent, trademark, copyright,
trade secret or other proprietary right of others, other than non-material
claims.

                  4.12. COMPLIANCE. The Company has not been advised, and has no
reason to believe, that it is not conducting its business in compliance with all
applicable laws, rules and regulations of the jurisdictions in which it is
conducting business, including, without limitation, all applicable local, state
and federal environmental laws and regulations; except where failure to be so in
compliance would not have a Material Adverse Effect.

                  4.13. TAXES. The Company has filed all necessary federal,
state and foreign income and franchise tax returns and has paid or accrued all
taxes shown as due thereon, and the Company has no knowledge of a tax deficiency
which has been or might be asserted or threatened against it which could have a
Material Adverse Effect.

                  4.14. TRANSFER TAXES. On the Closing Date, all stock transfer
or other taxes (other than income taxes) which are required to be paid in
connection with the sale and transfer of the Shares to be sold to the Purchaser
hereunder will be, or will have been, fully paid or provided for by the Company
and all laws imposing such taxes will be or will have been fully complied with.

                  4.15. INVESTMENT COMPANY. The Company is not an "investment
company" or an "affiliated person" of, or "promoter" or "principal underwriter"
for an investment company, within the meaning of the Investment Company Act of
1940, as amended.

                  4.16. OFFERING MATERIALS. The Company has not distributed and
will not distribute prior to the Closing Date any offering material in
connection with the offering and sale of the Shares other than the Private
Placement Memorandum or any amendment or supplement thereto. The Company has not
in the past nor will it hereafter take any action independent of the Placement
Agent to sell, offer for sale or solicit offers to buy any securities of the
Company which would bring the offer, issuance or sale of the Shares, as
contemplated by this Agreement, within the provisions of Section 5 of the
Securities Act, unless such offer, issuance or sale was or shall be within the
exemptions of Section 4 of the Securities Act.

                  4.17. INSURANCE. The Company is insured by recognized,
financially sound and reputable institutions with policies in such amounts and
with such deductibles and covering such risks as are generally deemed adequate
and customary for its businesses including, but not

                                      -6-
<PAGE>

limited to, policies covering real and personal property owned or leased by
the Company against theft, damage, destruction, acts of vandalism and
earthquakes. The Company has no reason to believe that it will not be able
(i) to renew its existing insurance coverage as and when such policies expire
or (ii) to obtain comparable coverage from similar institutions as may be
necessary or appropriate to conduct its business as now conducted and at a
cost that would not have a material adverse effect on the business,
properties, prospects, condition (financial or otherwise) or results of
operations of the Company. The Company has not been denied any insurance
coverage which it has sought or for which it has applied.

                  4.18. CONTRIBUTIONS. At no time since its incorporation has
the Company, directly or indirectly, (i) made any unlawful contribution to any
candidate for public office, or failed to disclose fully any contribution in
violation of law, or (ii) made any payment to any federal or state governmental
officer or official, or other person charged with similar public or quasi-public
duties, other than payments required or permitted by the laws of the United
States or any jurisdiction thereof.

                  4.19. ADDITIONAL INFORMATION. The Company represents and
warrants that the information contained in the following documents, which the
Placement Agent has furnished to the Purchaser, or will furnish prior to the
Closing, is or will be true and correct in all material respects as of their
respective final dates:

                  (a)      the Company's Annual Report on Form 10-K for the
                           fiscal year ended December 31, 1999;

                  (b)      the Company's Quarterly Report on Form 10-Q for the
                           fiscal quarter ended March 31, 2000;

                  (c)      the Company's Proxy Statement for the 2000 Annual
                           Meeting of Stockholders;

                  (d)      the Company's Current Report on Form 8-K filed
                           July 11, 2000;

                  (e)      the Registration Statement;

                  (f)      the Private Placement Memorandum, including all
                           addenda and exhibits thereto (other than the
                           Appendices); and

                  (g)      all other documents, if any, filed by the Company
                           with the Securities and Exchange Commission since
                           March 31, 2000 pursuant to the reporting requirements
                           of the Securities Exchange Act of 1934, as amended
                           (the "Exchange Act").

                  4.20. LEGAL OPINIONS. Prior to the Closing, (a) Pillsbury
Madison & Sutro LLP, counsel to the Company, will deliver its legal opinion to
the Placement Agent and (b) special

                                      -7-
<PAGE>

intellectual property counsel to the Company reasonably satisfactory to the
Placement Agent and its counsel will deliver its legal opinion to the
Placement Agent as to certain intellectual property matters, each in form and
in substance reasonably satisfactory to the Placement Agent and its counsel.
Each such opinion shall also state that each of the Purchasers may rely
thereon as though it were addressed directly to such Purchaser.

                  4.21. CERTIFICATE. At the Closing, the Company will deliver to
Purchaser a certificate executed by the Chairman of the Board or President and
the chief financial or accounting officer of the Company, dated the Closing
Date, in form and substance reasonably satisfactory to the Purchasers, to the
effect that the representations and warranties of the Company set forth in this
Section 4 are true and correct in all material respects as of the date of this
Agreement and as of the Closing Date, and the Company has complied with all the
agreements and satisfied all the conditions herein on its part to be performed
or satisfied on or prior to such Closing Date.

                  SECTION 5. REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE
PURCHASER. (a) The Purchaser represents and warrants to, and covenants with, the
Company that: (i) the Purchaser is knowledgeable, sophisticated and experienced
in making, and is qualified to make, decisions with respect to investments in
shares representing an investment decision like that involved in the purchase of
the Shares, including investments in securities issued by the Company, and has
requested, received, reviewed and considered all information it deems relevant
in making an informed decision to purchase the Shares; (ii) the Purchaser is
acquiring the number of Shares set forth in Section 2 above in the ordinary
course of its business and for its own account for investment (as defined for
purposes of the Hart-Scott-Rodino Antitrust Improvement Act of 1976 and the
regulations thereunder) only and with no present intention of distributing any
of such Shares or any arrangement or understanding with any other persons
regarding the distribution of such Shares within the meaning of Section 2(11) of
the Securities Act; (iii) the Purchaser will not, directly or indirectly, offer,
sell, pledge, transfer or otherwise dispose of (or solicit any offers to buy,
purchase or otherwise acquire or take a pledge of) any of the Shares except in
compliance with the Act and the Rules and Regulations; (iv) the Purchaser has
completed or caused to be completed the Registration Statement Questionnaire and
the Stock Certificate Questionnaire, both attached hereto as Appendix I, for use
in preparation of the Registration Statement, and the answers thereto are true
and correct as of the date hereof and will be true and correct as of the
effective date of the Registration Statement; (v) the Purchaser has, in
connection with its decision to purchase the number of Shares set forth in
Section 2 above, relied solely upon the Private Placement Memorandum and the
documents included therein and the representations and warranties of the Company
contained herein; and (vi) the Purchaser is an "accredited investor" within the
meaning of Rule 501 of Regulation D promulgated under the Securities Act.

                  (b) Unless such sale is pursuant to an applicable exemption
from the Securities Act, the Purchaser hereby covenants with the Company not to
make any sale of the Shares without satisfying the prospectus delivery
requirement under the Securities Act, and the Purchaser acknowledges and agrees
that such Shares are not transferable on the books of the

                                      -8-
<PAGE>

Company unless the certificate submitted to the transfer agent evidencing the
Shares is accompanied by a separate officer's certificate: (i) in the form of
Appendix II hereto, (ii) executed by an officer of, or other authorized
person designated by, the Purchaser, and (iii) to the effect that (A) the
Shares have been sold in accordance with the Registration Statement, the
Securities Act and the Rules and Regulations and any applicable state
securities or blue sky laws and (B) the requirement of delivering a current
prospectus has been satisfied. The Purchaser acknowledges that there may
occasionally be times when the Company must suspend the use of the prospectus
forming a part of the Registration Statement until such time as an amendment
or supplement to the Registration Statement or the Prospectus has been filed
by the Company and declared effective by the Commission, or until such time
as the Company has filed an appropriate report with the Commission pursuant
to the Exchange Act. The Purchaser hereby covenants that it will not sell any
Shares pursuant to said prospectus during the period commencing at the time
at which the Company gives the Purchaser written notice of the suspension of
the use of said prospectus and ending at the time the Company gives the
Purchaser written notice that the Purchaser may thereafter effect sales
pursuant to said prospectus. The Purchaser further covenants to notify the
Company promptly of the sale of all of its Shares.

                  (c) The Purchaser further represents and warrants to, and
covenants with, the Company that (i) the Purchaser has full right, power,
authority and capacity to enter into this Agreement and to consummate the
transactions contemplated hereby and has taken all necessary action to authorize
the execution, delivery and performance of this Agreement, and (ii) upon the
execution and delivery of this Agreement, this Agreement shall constitute a
valid and binding obligation of the Purchaser enforceable in accordance with its
terms, except as enforceability may be limited by applicable bankruptcy,
insolvency, reorganization, moratorium or similar laws affecting creditors' and
contracting parties' rights generally and except as enforceability may be
subject to general principles of equity (regardless of whether such
enforceability is considered in a proceeding in equity or at law) and except as
the indemnification agreements of the Purchaser in Section 7.3 hereof may be
legally unenforceable.

                  SECTION 6. SURVIVAL OF REPRESENTATIONS, WARRANTIES AND
AGREEMENTS. Notwithstanding any investigation made by any party to this
Agreement or by the Placement Agent, all covenants, agreements, representations
and warranties made by the Company and the Purchaser herein and in the
certificates for the Shares delivered pursuant hereto shall survive the
execution of this Agreement, the delivery to the Purchaser of the Shares being
purchased and the payment therefor.

                                      -9-
<PAGE>

                  SECTION 7.  REGISTRATION OF THE SHARES; COMPLIANCE WITH THE
SECURITIES ACT.

                  7.1.  REGISTRATION PROCEDURES AND EXPENSES.  The Company
shall:

                  (a)      as soon as practicable, prepare and file with the
                           Commission the Registration Statement on Form S-3
                           relating to the sale of the Shares by the Purchaser
                           from time to time through the automated quotation
                           system of the Nasdaq National Market or the
                           facilities of any national securities exchange on
                           which the Company's Common Stock is then traded or in
                           privately-negotiated transactions;

                  (b)      use its reasonable efforts subject to receipt of
                           necessary information from the Purchasers, to cause
                           the Commission to notify the Company of the
                           Commission's willingness to declare the Registration
                           Statement effective within 60 days after the
                           Registration Statement is filed by the Company;

                  (c)      prepare and file with the Commission (and promptly
                           notify the Purchaser of such filing) such amendments
                           and supplements to the Registration Statement and the
                           prospectus used in connection therewith as may be
                           necessary to keep the Registration Statement
                           effective until the earlier of (i) twenty-four months
                           after the effective date of the Registration
                           Statement or (ii) the date on which the Shares may be
                           resold by the Purchasers without registration by
                           reason of Rule 144(k) under the Securities Act or any
                           other rule of similar effect;

                  (d)      furnish to the Purchaser with respect to the Shares
                           registered under the Registration Statement (and to
                           each underwriter, if any, of such Shares) such
                           reasonable number of copies of prospectuses and such
                           other documents as the Purchaser may reasonably
                           request, in order to facilitate the public sale or
                           other disposition of all or any of the Shares by the
                           Purchaser;

                  (e)      file documents required of the Company for normal
                           blue sky clearance in states specified in writing by
                           the Purchaser; PROVIDED, HOWEVER, that the Company
                           shall not be required to qualify to do business or
                           consent to service of process in any jurisdiction in
                           which it is not now so qualified or has not so
                           consented; and

                  (f)      bear all expenses in connection with the procedures
                           in paragraphs (a) through (e) of this Section 7.1 and
                           the registration of the Shares pursuant to the
                           Registration Statement, other than fees and expenses,
                           if any, of counsel or other advisers to the Purchaser
                           or the Other Purchasers or underwriting discounts,
                           brokerage fees and commissions incurred by the
                           Purchaser or the Other Purchasers, if any.

                                      -10-
<PAGE>

                  7.2. TRANSFER OF SHARES AFTER REGISTRATION. The Purchaser
agrees that it will not effect any disposition of the Shares or its right to
purchase the Shares that would constitute a sale within the meaning of the
Securities Act, except as contemplated in the Registration Statement referred to
in Section 7.1 or as otherwise permitted by the Securities Act or applicable
law, and that it will promptly notify the Company of any changes in the
information set forth in the Registration Statement regarding the Purchaser or
its Plan of Distribution.

                  7.3.  INDEMNIFICATION.  For the purpose of this Section 7.3:

                  (i)      the term "Purchaser/Affiliate" shall include the
                           Purchaser and any affiliate of such Purchaser; and

                  (ii)     the term "Registration Statement" shall include any
                           final prospectus, exhibit, supplement or amendment
                           included in or relating to the Registration Statement
                           referred to in Section 7.1.

                  (a)      The Company agrees to indemnify and hold harmless
each of the Purchasers and each person, if any, who controls any Purchaser
within the meaning of the Securities Act, against any losses, claims,
damages, liabilities or expenses, joint or several, to which such Purchasers
or such controlling person may become subject, under the Securities Act, the
Exchange Act, or any other federal or state statutory law or regulation, or
at common law or otherwise (including in settlement of any litigation, if
such settlement is effected with the written consent of the Company), insofar
as such losses, claims, damages, liabilities or expenses (or actions in
respect thereof as contemplated below) arise out of or are based upon any
untrue statement or alleged untrue statement of any material fact contained
in the Registration Statement, including the prospectus, financial statements
and schedules, and all other documents filed as a part thereof, as amended at
the time of effectiveness of the Registration Statement, including any
information deemed to be a part thereof as of the time of effectiveness
pursuant to paragraph (b) of Rule 430A, or pursuant to Rule 434, of the Rules
and Regulations, or the prospectus, in the form first filed with the
Commission pursuant to Rule 424(b) of the Regulations, or filed as part of
the Registration Statement at the time of effectiveness if no Rule 424(b)
filing is required (the "Prospectus"), or any amendment or supplement
thereto, or arise out of or are based upon the omission or alleged omission
to state in any of them a material fact required to be stated therein or
necessary to make the statements in any of them, in light of the
circumstances under which they were made, not misleading, or arise out of or
are based in whole or in part on any inaccuracy in the representations and
warranties of the Company contained in this Agreement, or any failure of the
Company to perform its obligations hereunder or under law, and will reimburse
each Purchaser and each such controlling person for any legal and other
expenses as such expenses are reasonably incurred by such Purchaser or such
controlling person in connection with investigating, defending, settling,
compromising or paying any such loss, claim, damage, liability, expense or
action; PROVIDED, HOWEVER, that the Company will not be liable in any such
case to the extent that any such loss, claim, damage, liability or expense
arises out of or is based upon (i) an untrue statement or alleged untrue
statement or omission or alleged

                                      -11-
<PAGE>

omission made in the Registration Statement, the Prospectus or any amendment
or supplement thereto in reliance upon and in conformity with written
information furnished to the Company: by or on behalf of the Purchaser
expressly for use therein, or (ii) the failure of such Purchaser to comply
with the covenants and agreements contained in Sections 5(b) or 7.2 hereof
respecting sale of the Shares (unless such failure shall be a result of the
Company breaching any of its obligations to the Purchaser hereunder), or
(iii) the inaccuracy of any representations made by such Purchaser herein or
(iv) any statement or omission in any Prospectus that is corrected in any
subsequent Prospectus that was delivered to the Purchaser prior to the
pertinent sale or sales by the Purchaser.

                  (b)      Each Purchaser will severally indemnify and hold
harmless the Company, each of its directors, each of its officers who signed
the Registration Statement and each person, if any, who controls the Company
within the meaning of the Securities Act, against any losses, claims,
damages, liabilities or expenses to which the Company, each of its directors,
each of its officers who signed the Registration Statement or controlling
person may become subject, under the Securities Act, the Exchange Act, or any
other federal or state statutory law or regulation, or at common law or
otherwise (including in settlement of any litigation, if such settlement is
effected with the written consent of such Purchaser) insofar as such losses,
claims, damages, liabilities or expenses (or actions in respect thereof as
contemplated below) arise out of or are based upon (i) any failure to comply
with the covenants and agreements contained in Sections 5(b) or 7.2 hereof
respecting the sale of the Shares (unless such failure shall be a result of
the Company breaching any of its obligations to the Purchaser hereunder) or
(ii) the inaccuracy of any representation made by such Purchaser herein or
(iii) any untrue or alleged untrue statement of any material fact contained
in the Registration Statement, the Prospectus, or any amendment or supplement
thereto, or arise out of or are based upon the omission or alleged omission
to state therein a material fact required to be stated therein or necessary
to make the statements therein not misleading, in each case to the extent,
but only to the extent, that such untrue statement or alleged untrue
statement or omission or alleged omission was made in the Registration
Statement, the Prospectus, or any amendment or supplement thereto, in
reliance upon and in conformity with written information furnished to the
Company by or on behalf of any Purchaser expressly for use therein, and will
reimburse the Company, each of its directors, each of its officers who signed
the Registration Statement or controlling person for any legal and other
expense reasonably incurred by the Company, each of its directors, each of
its officers who signed the Registration Statement or controlling person in
connection with investigating, defending, settling, compromising or paying
any such loss, claim, damage, liability, expense or action; PROVIDED,
HOWEVER, that no Purchaser shall be liable for any amount in excess of the
net proceeds (the "Net Proceeds") received by such Purchaser with respect to
such Purchaser's sale of the Shares.

                  (c)      Promptly after receipt by an indemnified party
under this Section 7.3 of notice of the threat or commencement of any action,
such indemnified party will, if a claim in respect thereof is to be made
against an indemnifying party under this Section 7.3 promptly notify the
indemnifying party in writing thereof; but the omission so to notify the
indemnifying party will not relieve it from any liability which it may have
to any indemnified party for

                                      -12-
<PAGE>

contribution or otherwise than under the indemnity agreement contained in
this Section 7.3 or to the extent it is not materially prejudiced as a result
of such failure. In case any such action is brought against any indemnified
party and such indemnified party seeks or intends to seek indemnity from an
indemnifying party, the indemnifying party will be entitled to participate
in, and, to the extent that it may wish, jointly with all other indemnifying
parties similarly notified, to assume the defense thereof with counsel
reasonably satisfactory to such indemnified party; provided, however, if the
defendants in any such action include both the indemnified party and the
indemnifying party and the indemnified party shall have reasonably concluded
that there may be a conflict between the positions of the indemnifying party
and the indemnified party in conducting the defense of any such action or
that there may be legal defenses available to it and/or other indemnified
parties which are different from or additional to those available to the
indemnifying party, the indemnified party or parties shall have the right to
select separate counsel to assume such legal defenses and to otherwise
participate in the defense of such action on behalf of such indemnified party
or parties. Upon receipt of notice from the indemnifying party to such
indemnified party of its election so to assume the defense of such action and
approval by the indemnified party of counsel, the indemnifying party will not
be liable to such indemnified party under this Section 7.3 for any legal or
other expenses subsequently incurred by such indemnified party in connection
with the defense thereof unless (i) the indemnified party shall have employed
such counsel in connection with the assumption of legal defenses in
accordance with the proviso to the preceding sentence (it being understood,
however, that the indemnifying party shall not be liable for the expenses of
more than one separate counsel, approved by such indemnifying party in the
case of paragraph (a), representing the indemnified parties who are parties
to such action) or (ii) the indemnified party shall not have employed counsel
reasonably satisfactory to the indemnified party to represent the indemnified
party within a reasonable time after notice of commencement of action, in
each of which cases the reasonable fees and expenses of counsel shall be at
the expense of the indemnifying party.

                  (d)      If the indemnification provided for in this
Section 7.3 is required by its terms but is for any reason held to be
unavailable to or otherwise insufficient to hold harmless an indemnified
party under paragraphs (a), (b) or (c) of this Section 7.3 in respect to any
losses, claims, damages, liabilities or expenses referred to herein, then
each applicable indemnifying party shall contribute to the amount paid or
payable by such indemnified party as a result of any losses, claims, damages,
liabilities or expenses referred to herein (i) in such proportion as is
appropriate to reflect the relative fault of the Company and the Purchaser in
connection with the statements or omissions or inaccuracies in the
representations and warranties in this Agreement which resulted in such
losses, claims, damages, liabilities or expenses, as well as any other
relevant equitable considerations. The relative fault of such Selling
Stockholders and each Purchaser shall be determined by reference to, among
other things, whether the untrue or alleged statement of a material fact or
the omission or alleged omission to state a material fact or the inaccurate
or the alleged inaccurate representation and/or warranty relates to
information supplied by the Company or by such Purchaser and the parties'
relative intent, knowledge, access to information and opportunity to correct
or prevent such statement or omission. The amount paid or payable by a party
as a result of the losses, claims, damages, liabilities and expenses referred
to above shall be deemed to include, subject to the limitations set forth in
paragraph (c) of this Section 7.3, any legal or other fees or expenses
reasonably incurred by such party in connection with investigating or
defending any action or claim. The provisions set forth in paragraph (c)

                                      -13-
<PAGE>

of this Section 7.3 with respect to the notice of the threat or commencement
of any threat or action shall apply if a claim for contribution is to be made
under this paragraph (d); PROVIDED, HOWEVER, that no additional notice shall
be required with respect to any threat or action for which notice has been
given under paragraph (c) for purposes of indemnification. The Company and
each Purchaser agree that it would not be just and equitable if contribution
pursuant to this Section 7.3 were determined solely by pro rata allocation
(even if the Purchaser were treated as one entity for such purpose) or by any
other method of allocation which does not take account of the equitable
considerations referred to in this paragraph. Notwithstanding the provisions
of this Section 7.3, no Purchaser shall be required to contribute any amount
in excess of the amount by which the Net Proceeds exceeds the amount of any
damages that such Purchaser has otherwise been required to pay by reason of
such untrue or alleged untrue statement or omission or alleged omission. No
person guilty of fraudulent misrepresentation (within the meaning of Section
11(f) of the Securities Act) shall be entitled to contribution from any
person who was not guilty of such fraudulent misrepresentation. The
Purchasers' obligations to contribute pursuant to this Section 7.3 are
several and not joint.

                  7.4. TERMINATION OF CONDITIONS AND OBLIGATIONS. The
restrictions imposed by Section 5 or this Section 7 upon the transferability
of the Shares shall cease and terminate as to any particular number of the
Shares upon the passage of twenty-four months from the effective date of the
Registration Statement covering such Shares or at such time as an opinion of
counsel satisfactory in form and substance to the Company shall have been
rendered to the effect that such conditions are not necessary in order to
comply with the Securities Act.

                  7.5. INFORMATION AVAILABLE. So long as the Registration
Statement is effective covering the resale of Shares owned by the Purchaser,
the Company will furnish to the Purchaser:

                  (a)      as soon as practicable after available (but in the
                           case of the Company's Annual Report to Stockholders,
                           within 120 days after the end of each fiscal year
                           of the Company), one copy of (i) its Annual Report
                           to Stockholders (which Annual Report shall contain
                           financial statements audited in accordance with
                           generally accepted accounting principles by a
                           national firm of certified public accountants), (ii)
                           if not included in substance in the Annual Report to
                           Stockholders, its Annual Report on Form 10-K, (iii)
                           if not included in substance in its Quarterly Reports
                           to Shareholders, its quarterly reports on Form 10-Q,
                           and (iv) a full copy of the particular Registration
                           Statement covering the Shares (the foregoing, in each
                           case, excluding exhibits);

                  (b)      upon the reasonable request of the Purchaser, a
                           reasonable number of copies of the prospectuses to
                           supply to any other party requiring such
                           prospectuses;

                                      -14-
<PAGE>

and the Company, upon the reasonable request of the Purchaser, will meet with
the Purchaser or a representative thereof at the Company's headquarters to
discuss information relevant for disclosure in the Registration Statement
covering the Shares subject to appropriate confidentiality limitations.

                  SECTION 8. BROKER'S FEE. The Purchaser acknowledges that the
Company intends to pay to the Placement Agent a fee in respect of the sale of
the Shares to the Purchaser. Each of the parties hereto hereby represents that,
on the basis of any actions and agreements by it, there are no other brokers or
finders entitled to compensation in connection with the sale of the Shares to
the Purchaser.

                  SECTION 9. NOTICES. All notices, requests, consents and other
communications hereunder shall be in writing, shall be mailed by first-class
registered or certified airmail, facsimile (with receipt confirmed by telephone)
or nationally recognized overnight express courier postage prepaid, and shall be
deemed given when so mailed and shall be delivered as addressed as follows:

                  (a)      if to the Company, to:
                                    Matrix Pharmaceutical, Inc.
                                    34700 Campus Drive
                                    Fremont, California  94555
                                    Attn:  Michael D. Casey

                           with a copy to:

                                    Pillsbury Madison & Sutro LLP
                                    50 Fremont Street
                                    San Francisco, CA 94105
                                    Attention: Thomas E. Sparks, Jr., Esq.

                           or to such other person at such other place as the
                           Company shall designate to the Purchaser in writing;
                           and

                  (b)      if to the Purchaser, at its address as set forth at
                           the end of this Agreement, or at such other address
                           or addresses as may have been furnished to the
                           Company in writing.

                  SECTION 10.  CHANGES.  This Agreement may not be modified
or amended except pursuant to an instrument in writing signed by the Company
and the Purchaser.

                  SECTION 11.  HEADINGS.  The headings of the various
sections of this Agreement have been inserted for convenience of reference
only and shall not be deemed to be part of this Agreement.

                                      -15-
<PAGE>

                  SECTION 12. SEVERABILITY. In case any provision contained
in this Agreement should be invalid, illegal or unenforceable in any respect,
the validity, legality and enforceability of the remaining provisions
contained herein shall not in any way be affected or impaired thereby.

                  SECTION 13.  GOVERNING LAW.  This Agreement shall be
governed by and construed in accordance with the laws of the State of New
York and the federal securities laws of the United States of America.

                  SECTION 14. COUNTERPARTS. This Agreement may be executed in
two or more counterparts, each of which shall constitute an original, but all
of which, when taken together, shall constitute but one instrument, and shall
become effective when one or more counterparts have been signed by each party
hereto and delivered to the other parties.

                                      -16-
<PAGE>

                  IN WITNESS WHEREOF, the parties hereto have caused this
Agreement to be executed by their duly authorized representatives as of the day
and year first above written.

                                         MATRIX PHARMACEUTICAL, INC.

                                         By
                                           ---------------------------------
                                           Name:
                                           Title:

Print or Type:
                                         Name of Purchaser
                                           (Individual or Institution):

                                           ---------------------------------

                                         Name of Individual
                                           representing Purchaser
                                           (if an Institution):

                                           ---------------------------------

                                         Title of Individual
                                           representing Purchaser
                                           (if an Institution):

                                           ---------------------------------

Signature by:
                                         Individual Purchaser or Individual
                                           representing Purchaser:

                                           ---------------------------------

                                         Address:
                                                 ---------------------------
                                         Telephone:
                                                   -------------------------
                                         Telecopier:
                                                    ------------------------

                                      -17-
<PAGE>

                     SUMMARY INSTRUCTION SHEET FOR PURCHASER

                   (to be read in conjunction with the entire
                        Purchase Agreement which follows)

A.       Complete the following items on BOTH Purchase Agreements:

         1.       Page 14 - Signature:

             (i)  Name of Purchaser (Individual or Institution)

             (ii) Name of Individual representing Purchaser (if an Institution)

            (iii) Title of Individual representing Purchaser (if an Institution)

             (iv) Signature of Individual Purchaser or Individual representing
                  Purchaser

         2.       Appendix I - Stock Certificate Questionnaire:

                  Provide the information requested by the Stock Certificate
                  Questionnaire.

                  Appendix I - Registration Statement Questionnaire:

                  Provide the information requested by the Registration
                  Statement Questionnaire.

         3.       Return BOTH properly completed and signed Purchase Agreements
                  including the properly completed Appendix I to:

                  Banc America Securities LLC
                  9 West 57th Street
                  New York, New York  10019
                  Attention:  Paul Donofrio

B.       Instructions regarding the transfer of funds for the purchase of Shares
         will be sent by facsimile to the Purchaser by the Placement Agent at a
         later date.

C.       Upon the resale of the Shares by the Purchasers after the Registration
         Statement covering the Shares is effective, as described in the
         Purchase Agreement, the Purchaser:

                  (i)      must deliver a current prospectus of the Company to
                           the buyer (prospectuses must be obtained from the
                           Company at the Purchaser's request); and

                  (ii)     must send a letter in the form of Appendix II to the
                           Company so that the Shares may be properly
                           transferred.

<PAGE>

                                                                    Appendix I
                                                                   (one of two)

BANC OF AMERICA SECURITIES LLC

STOCK CERTIFICATE QUESTIONNAIRE

         Pursuant to Section 3 of the Agreement, please provide us with the
following information:

1.       The exact name that your Shares are to be registered in (this is the
         name that will appear on your stock certificate(s)). You may use a
         nominee name if appropriate:

         -----------------------

2.       The relationship between the Purchaser of the Shares and the Registered
         Holder listed in response to item 1 above:

         ----------------------

3.       The mailing address of the Registered Holder listed in response to
         item 1 above:

         ----------------------

         ----------------------

         ----------------------

         ----------------------

4.       The Social Security Number or Tax Identification Number of the
         Registered Holder listed in response to item 1 above:

         ----------------------

<PAGE>
                                                                    Appendix I
                                                                   (two of two)

                           MATRIX PHARMACEUTICAL, INC.
                      REGISTRATION STATEMENT QUESTIONNAIRE

         In connection with the preparation of the Registration Statement,
please provide us with the following information:

         1.   Pursuant to the "Selling Shareholder" section of the Registration
Statement, please state your or your organization's name exactly as it should
appear in the Registration Statement:

--------------------------------------

         2.   Please provide the number of shares that you or your organization
will own immediately after Closing, including those Shares purchased by you or
your organization pursuant to this Purchase Agreement and those shares purchased
by you or your organization through other transactions:

--------------------------------------

         3.   Have you or your organization had any position, office or other
material relationship within the past three years with the Company or its
affiliates?

         _____ Yes         _____ No

         If yes, please indicate the nature of any such relationships below:

         -----------------------------------------------------------------

         -----------------------------------------------------------------

         -----------------------------------------------------------------

<PAGE>

                                                                  APPENDIX II

Attention:

                   PURCHASER'S CERTIFICATE OF SUBSEQUENT SALE

         The undersigned, [an officer of, or other person duly authorized by]
________________________________________________________
  [fill in official name of individual or institution]

hereby certifies that he/she [said institution] is the Purchaser of the shares

evidenced by the attached certificate, and as such, sold such shares on ______
                                                                        [date]
in accordance with Registration Statement number
_______________________________________________________________________
  [fill in the number of or otherwise identify Registration Statement]

and the requirement of delivering a current prospectus by the Company has been

complied with in connection with such sale.

Print or type:

         Name of Purchaser
           (Individual or
            Institution):           ______________________

         Name of Individual
           representing
           Purchaser (if an
           Institution):            ______________________

         Title of Individual
           representing
           Purchaser (if an
           Institution):            ______________________

Signature by:

         Individual Purchaser
          or Individual
          representing
          Purchaser:                ______________________

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