Document:

<PAGE>   1
                                                                 EXHIBIT 10.6(a)

                        ADDENDUM TO EMPLOYMENT AGREEMENT

Reference is made to the Employment Agreement (the "Agreement") effective as of
January 1, 2000 between Jeffrey S. Williams ("Williams") and Genomic Solutions
Inc. (the "Company").

The parties have determined that the Agreement described shall be modified,
effective January 1, 2001, and such modifications shall be binding on Williams
and the Company. Except as expressly modified by this addendum, the Agreement
remains in full force and effect.

         3.    Devotion to the Company's Business. Williams shall devote his
         entire productive time, ability and attention to the business of the
         Company during the term of this Agreement; however, the expenditure of
         reasonable amounts of time for various charitable and other community
         activities, or to Williams own personal investments and projects,
         provided the amount of time so devoted does not materially impair,
         detract or adversely affect the performance of Williams duties under
         this Agreement, shall not be deemed a breach of this Agreement. No
         outside business activities will be competitive with current or planned
         business lines of the Company. If an activity is unclear as to its
         potential conflict with the Company, a panel of non-interested GSI
         directors shall make a final determination.

         4b.   Base Compensation. As compensation for the services to be
         performed hereafter, the Company shall pay to Williams, for the
         calendar year 2001, a base salary (the "Base Salary") of Three Hundred
         Forty-Five Thousand Dollars ($345,000), payable in twenty-four (24)
         equal semi-monthly payments of Fourteen Thousand Three Hundred
         Seventy-Five Dollars ($14,375).

         4d,I. Performance Bonuses. Williams shall be eligible for the
         performance bonuses set forth herein, which if earned, shall be paid
         either annually, semi-annually or quarterly as determined by the
         Compensation Committee of the Board. For each calendar year under this
         Agreement, Williams shall be eligible for a performance bonus not to
         exceed Thirty-Five Percent (35%) of Williams' Base Salary for the year
         in issue. The amount, if any, shall be determined in accordance with
         criteria established by the Compensation Committee of the Board, in
         consultation with Williams, at the beginning of each calendar year.
         Should a performance bonus be earned, it shall be paid no later than
         March 31st of the year following the year in which the bonus was
         earned.

Agreed to and accepted this 19th day of December, 2000.

Genomic Solutions, Inc.

By:  /s/ J. Matthew Mackowski
     -------------------------------
       J. Matthew Mackowski
       Chairman, Compensation Committee

By: /s/  Jeffrey S. Williams
    --------------------------------
       Jeffrey S. Williams<PAGE>   1
                                                                EXHIBIT 10.16(a)

                       SECOND AMENDMENT TO LEASE AGREEMENT

This Second Amendment shall be a part of the original Lease Agreement with an
effective date of July 22, 1998, between DART CONTAINER CORPORATION OF MICHIGAN,
a Michigan corporation ("Landlord"), and GENOMIC SOLUTIONS, INC., a Delaware
corporation ("Tenant"), covering the premises known as Lot 4A, Oakwood Executive
Park, more commonly known as 3120 Sovereign Drive, Suite A, Lansing, Michigan
48911. The original Lease Agreement has a Commencement Date of July 22, 1998,
and has a Termination Date of July 21, 2003.

Tenant, in addition to Lot 4A, will also be leasing Lot 4B for the remainder of
the lease term.

Lease payments for Lot 4B will be as follows:

           $2,436.75 per month from July 1, 2000 through June 30, 2001

           $2,511.16 per month from July 1, 2001 through June 30, 2002

           $2,585.52 per month from July 1, 2002 through July 21, 2003

These payments are in addition to what Tenant is currently paying for Lot 4A

Tenant shall pay to Landlord Four Hundred Ninety-Five Dollars ($495.00) per
month as its prorated share of estimated CAM Charges paid by Landlord on behalf
of the Tenant for Lot 4B. These estimated CAM Charges are in addition to the
estimated CAM Charges Tenant is currently paying for Lot 4A.

Landlord will pay for new carpet and baseboard for Lot 4B. Carpeting shall be
the same grade as that used throughout the Park.

The cost of all other improvements to Lot 4B shall be the responsibility of
Tenant and if costs are paid by Landlord they may be amortized over the
remaining term of the Lease.

All other terms and conditions of the original Lease Agreement shall remain in
effect as first written or amended.

The effective date of this Second Amendment shall be June 1, 2000, regardless of
the date written below.

WITNESS                                 GENOMIC SOLUTIONS, INC.
                                        a Delaware corporation (Tenant)

/s/  Steven J. Richvalsky               /s/  Jeffrey S. Williams
-----------------------------------     ----------------------------------
[signature]                             By:  Jeffrey S. Williams
                                        Its: President and CEO
Steven J. Richvalsky
-----------------------------------
[print name]                            Date:  July 5   , 2000
                                             -----------

                                        DART CONTAINER CORPORATION OF
                                        MICHIGAN, a Michigan corporation
WITNESS                                 (Landlord)

/s/ G K Sewell                          /s/  William L. Myers
-----------------------------------     ----------------------------------
[signature]                             By:  William L. Myers
                                        Its: Treasurer
G K Sewell
-----------------------------------
[print name]                            Date:  July 18  , 2000
                                             -----------<PAGE>   1
                                                                EXHIBIT 10.17(a)

                            FOURTH ADDENDUM TO LEASE

This agreement shall serve as the fourth Addendum to the Lease dated August 7,
1997, by and between Highland Industrial Properties L.L.C., (Lessor) and Genomic
Solutions, Inc., formerly know as B.I. Systems Corp. (Lessee), for office and
warehouse space located at 4355 Varsity Drive Suite "F" and 4401 Varsity Drive
Suite "F," Ann Arbor, Michigan.

Lessor and Lessee hereby agree to this Fourth Addendum to Lease on the following
terms and conditions:

1.   Lessor agrees to Lease to Lessee and Lessee agrees to Lease from Lessor an
     additional 6,689 square feet of office and warehouse space at 4401 Varsity
     Drive, Suite "F." After the effective date of this Fourth Addendum to
     Lease, Lessee shall have Leased a total square footage of 21,165 square
     feet comprised of 4355 Varsity, Suite "F" at 14,476 square feet and 4401
     Varsity, Suite "F" at 6,689 square feet.

2.   Lessor and Lessee agree that this Fourth Addendum shall take effect and
     commence on June 1, 2000 wherein both properties will have coterminous
     lease expiration dates with the original Lease dated August 7, 1997. The
     termination date for both Leases shall be midnight December 31, 2002.

3.   Lessor and Lessee agree that the Lease rates for both premises shall be as
     follows:

          June    1, 2000 to December 31, 2000: $  9.72 per sq. ft. NNN
          January 1, 2001 to December 31, 2001: $  9.97 per sq. ft. NNN
          January 1, 2002 to December 31, 2002: $ 10.22 per sq. ft. NNN

4.   Lessee and Lessor further agree that if they enter into a new Lease for a
     facility or property owned or controlled by Lessor during the term of this
     Fourth Addendum Lease, Lessee and Lessor agree to terminate the original
     Lease and the Fourth Addendum to Lease and execute a new Lease Agreement at
     the time Lessee takes occupancy of the new Leased Premises. Until the time
     of commencement of the new Lease, Lessee shall remain liable for rent under
     the Fourth Addendum and original Lease.

All remaining terms and conditions of the original Lease and Addendums thereof,
including this Fourth Addendum not inconsistent herewith shall remain in full
force and effect.

                                   HIGHLAND INDUSTRIAL PROPERTIES LLC (LESSOR)

Date: May 17, 2000                 By: /s/ Mark Lewis
      ------------------               --------------------------------------

                                   Its:  Member
                                       --------------------------------------

                                   GENOMIC SOLUTIONS, INC. (LESSEE)

Date: May 17, 2000                 By: /s/ Jeffrey S. Williams
      ------------------               --------------------------------------

                                   Its: President and CEO
                                       --------------------------------------<PAGE>   1
                                                                   EXHIBIT 10.18

SUBLEASE AND SERVICE AGREEMENT

     THIS AGREEMENT is made and entered into by and between Advanced Modular
Power Systems, Inc., a corporation ("Sublessor") and Genomic Solutions, Inc., a
corporation ("Sublessee") as of January 1, 2001. This Agreement also has a
signed and executed Appendix which is made a part of this Agreement.

WITNESSETH:

     WHEREAS, Sublessor presently leases the following described premises under
that certain Master Lease dated January 1, 1999, between Highland Industrial
Properties, L.L.C., as Landlord, (hereinafter called "Landlord") and Sublessor
as tenant (hereinafter the "Lease"), a copy of which Lease has been received by
Sublessee:

     2250 square feet of space (includes allocation of common areas) at 4370
     Varsity Drive, Ann Arbor, Michigan 48108, including one (1) office and
     twelve (12) cubicles (hereinafter the "Premises");

and

     WHEREAS, Sublessor now desires to sublease the Premises to Sublessee, and
Sublessee desires to sublease all of the agreed to space on Premises from
Sublessor.

     NOW, THEREFORE, in consideration of the sum of $ 10.00, the receipt and
sufficiency of which is hereby acknowledged, the parties hereto do hereby agree
as follows:

     1.   Grant. Sublessor hereby subleases to Sublessee, its successors and
assigns, all of its right, title and interest in and to the Premises; TO HAVE
AND TO HOLD THE SAME unto Sublessee, its successors and assigns, from and after
January 1, 2001, through December 31, 2001, unless terminated as hereinafter
provided, subject to the rental, terms, covenants and conditions contained
herein. In addition to the Premises, Sublessee shall have access, in common with
others, to the common facilities, the reception area, receiving and shipping
areas, conference rooms, employee cafeteria, and storage areas.

     2.   Rent. From and after January 1, 2001, Sublessee hereby agrees to pay
monthly in advance on the first day of each month the sum of $4800 Rent ($25.60
per sq. ft) beginning January 1, 2001.(1) In addition, Sublessee shall pay its
prorata share (based on the estimated life of the item compared to the term of
the Sublease) of any major repairs or replacements.(2)

     3.   Obligation to Landlord. Sublessee hereby agrees that the obligations
herein assumed by Sublessee shall inure jointly and severally to the Landlord
and to the Sublessor herein and to the successors and assigns of each. Sublessor
shall promptly forward to Landlord all rents received from Sublessee pursuant to
paragraph 2, together with such additional rental amounts necessary for full
payment of the rent due under the Lease. In the event Sublessor defaults under
the terms of the Lease, Sublessor shall indemnify and hold Sublessee harmless
from and against any and all claims, liabilities, costs or expense, including
reasonable attorneys' fees incurred by Sublessee as a result of Sublessor's
default under the Lease. Sublessor grants and assigns to Sublessee the right to
receive services and benefits as Tenant under the Lease.

         4. Lease. Sublessee's rights pursuant to the Sublease are subject and
subordinate at all times to the Lease and to all of the covenants and agreements
of the Lease, except as expressly modified by this Sublease.

--------

(1)  The monthly rental rate is considered full service gross and no other
expense shall be incurred by Sublessee except as defined within this Agreement.

(2)  Sublessee shall have the right to review cost prior to assessment.
Sublessee will pay pro rata share on a NET 30 basis.

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<PAGE>   2

Sublessee shall not do anything in connection with Sublessee's use or occupancy
of the Premises which would violate any Lease covenants or agreements. As to the
Premises, Sublessee expressly assumes to be bound by all obligations, covenants
and restrictions which are set forth in the Lease in the same manner as these
obligations, covenants and restrictions are binding upon Sublessor, as Tenant
under the Lease, except as expressly modified by this Sublease. Except as
modified hereby, Sublessee shall perform all of Sublessor's duties and
obligations under the Lease which relate to the Premises. Sublessor shall have
the same rights against Sublessee with respect to this Sublease as the Landlord
has against the Sublessor, as Tenant, pursuant to the Lease. The Landlord, under
the Lease, or the Sublessor may enforce against Sublessee, each in its own
capacity, any of the rights granted to the Landlord or hereunder pursuant to the
Lease, except as expressly modified by this Sublease. Sublessor may not grant to
Sublessee, and nothing in the Sublease shall be construed or interpreted to
grant, any greater rights than the Sublessor has received as Tenant from the
Landlord pursuant to the Lease. Sublessee does not have any greater rights
against Sublessor with respect to this Sublease or the Premises than Sublessor
has as Tenant against the Landlord with respect to the Lease and the Premises.

     5.   Services. Sublessor shall provide Sublessee with telephone instruments
and use of switch, utilities (including high purity distilled water), janitorial
services, ordinary maintenance and repair as part of the Base Rent for ordinary
office use. Sublessee shall pay for the cost of repairing or replacing the
telephone instruments or other equipment which become damaged or inoperable due
to Sublessee's use. Sublessee shall pay for its telephone service beyond
reasonable local calls, including all international calls.

     6.   Assignment and Subletting. Sublessee shall not voluntarily, by
operation of law, or otherwise, assign or permit to be assigned this Sublease or
any interest herein or sublease the Premises or any part thereof without written
consent of the Landlord and Sublessor. Sublessor's consent shall not be
unreasonably withheld or delayed. Sublessee shall have the right, without
Sublessor's approval to assign or sublease all or any part of the premise to any
parent, subsidiary, affiliated company or entity into which it is merged.

     7.   Default. The failure to comply with any of the terms and conditions
hereof by Sublessee shall constitute a default hereunder. In addition, any act
or omission by Sublessee which could constitute a default by Sublessor as Tenant
under the Lease shall constitute a default by Sublessee under this Sublease.
Sublessor has the right, but not the obligation, to cure any act or omission by
Sublessee which would constitute a default under the Lease or could after notice
and the passage of time, constitute a default under the Lease and to recover
from the Sublessee the costs incurred by Sublessor, including attorneys' fees,
in curing the act or omission by Sublessee. All remedies provided by the Lease
which are hereby expressly incorporated by reference, shall be available to
Sublessor against Sublessee in the event of default. Failure to perform any
covenant, term or condition hereof which is not cured within ten (10) days after
receipt of written notice by Sublessee from Sublessor shall constitute a default
under the Lease and hereunder and entitle Sublessor to all rights of the
Landlord under the Lease or at law. In the event of default by Sublessor under
the Lease, Sublessee shall attorn to Landlord at Landlord's request. Sublessee
shall have all rights against Sublessor as Tenant has against Landlord under the
terms of the Lease.

     8.   Restoration of Premises. No alterations or improvements to the
Premises shall be made without the prior written consent of the Landlord and of
the Sublessor. All fixtures, equipment, improvements and installations
(Property) attached to, or built into, the Premises at the commencement of, or
during the term of, the Sublessee shall, upon termination of this Sublease, and
without any obligation of Sublessor to compensate Sublessee therefor, be and
remain part of the Premises and be deemed the property of Sublessor, provided
that Sublessee shall have the obligation to remove any of its trade fixtures,
furniture and equipment and such alterations and improvements made during the
term hereof if so requested by Sublessor. In the event of such removal,
Sublessee agrees to promptly reimburse Sublessor for the cost of necessary
repairs required as the result of damage done to the Premises or the Building.
Any of the Sublessee's property not removed at the expiration or termination of
the Lease shall remain the property of the Sublessor.

     9.   Security. Sublessor has a current contract with the Department of
Energy and Lockheed Martin which is currently interpreted as being subject to
ITAR (International Trafficking in Arms Regulations). Sublessor does not do any
Classified Research. However, ITAR require that access to technical information
and materials for the project in question be restricted to United States
citizens and permanent residents of the United States (green cards). Sublessee
agrees that in the event that it has employees or visitors that are not either
United States citizens or permanent residents of the United States, they will
identify them to Sublessor upon entry. Sublessor will provide

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<PAGE>   3

identification which will be worn by such employees or visitors at all times
while on the premises in order to demonstrate their status. Further, Sublessee
agrees to instruct Sublessee's staff and visitors to respect the posted signs
and not to enter into areas into which entry is limited to certain authorized
personnel. Sublessee agrees that it will further instruct its staff that after
ordinary business hours, entry to restricted areas will be limited to those
persons to whom entry is specifically permitted.

     10.  Insurance. Sublessee, at its sole expense, will obtain and maintain at
all times until termination of this Sublease and surrender of the Premises to
Sublessor, a primary policy of insurance covering the Premises and providing the
insurance protection described in this Section. The liability coverage under the
primary policy will name Sublessor and Landlord as additional insured parties,
and will provide comprehensive general public liability insurance including
blanket contractual coverage against claims for or arising out of bodily injury,
death or property damage, occurring in, on or about the Premises or property in,
on or about the streets, sidewalks or properties adjacent to the Premises. The
limits of coverage will be, initially, if dual limits are provided, not less
than One Million Dollars ($1,000,000.00) with respect to injury or death of a
single person, not less than One Million Dollars ($1,000,000.00) with respect to
any one occurrence and not less than One Million Dollars ($1,000,000.00) with
respect to any one occurrence of property damage, or, in the alternative, a
single limit policy in the amount of One Million Dollars ($1,000,000.00). The
insurance policy or policies to be provided by Sublessee hereunder shall be
issued by an insurance company or companies having an A.M. Best Company rating
of not less than "A". Each policy procured by Sublessee under this Section must
provide for at least thirty (30) days written notice to Sublessor of any
cancellation. Sublessee shall provide evidence satisfactory to Sublessor of such
insurance.

     11.  Environmental Matters. Sublessee shall be fully responsible, at its
own expense, for the control and appropriate handling of any hazardous or toxic
(including radioactive) chemicals, materials or other substances used or stored
on the Premises in connection with Sublessee's business conducted therein.
Sublessor shall be fully responsible, at its own expense, for the control and
appropriate handling of any hazardous or toxic (including radioactive)
chemicals, materials or other substances on the Premises. Sublessee shall not
spill, introduce, discharge or bury any hazardous or toxic chemical, substance
or contaminant of any kind in, on, or under the Premises or any portion thereof,
or permit the discharge thereof into the sanitary or storm sewer or water system
serving the Premises, or into any municipal or other governmental water system
or storm and/or sanitary sewer system without first obtaining the written
license, permit or other approval of all governmental agencies having
jurisdiction there over, and in any event Sublessee shall employ all appropriate
safeguards and procedures necessary or appropriate to protect such systems from
contamination. Sublessee shall undertake, at its expense, any necessary and/or
appropriate cleanup process in connection with any breach of the foregoing
covenant, and without limiting Sublessee's other indemnity or insurance
obligations under this Sublease, Sublessee shall indemnify and hold harmless
Sublessor and Landlord from and against all liability, whether direct, indirect,
consequential or otherwise, arising from any incident or occurrence on or about
the Premises during Sublessee's occupancy pertaining to any hazardous or toxic
chemical, substance or contaminant caused by or permitted to occur by Sublessee.
The obligation of Sublessee under this Section, including expressly but without
limitation the foregoing indemnity, shall survive the expiration or earlier
termination of this Sublease, anything to the contrary contained herein
notwithstanding. Sublessor will provide warranties concerning the absence of
hazardous materials currently and will be responsible for all costs associated
with the removal of any that are present for the land and building throughout
the Lease term if said materials are not as a result of Sublessee's activities.

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<PAGE>   4

     12.  Notices. Any notice, consent, approval, agreement, certification,
request, invoice, bill, demand, statement, acceptance or other communication
hereunder ("Notice") shall be in writing and shall have been duly given or
furnished if delivered personally or mailed in a postpaid envelope (registered
or certified mail only) addressed to Sublessor or Sublessee at the address set
forth below, or to such other address or addressee as either party may designate
by a Notice given pursuant thereto:

     Sublessor:    Advanced Modular Power Systems, Inc.
                   4370 Varsity Drive
                   Ann Arbor, Michigan 48108
                   Attention: George Levy

     Sublessee:    Genomic Solutions, Inc.
                   4355 Varsity Drive, Suite E
                   Ann Arbor, MI 48108

     13.  Termination. Either party may terminate this Sublease with 30 days
advance notice, except that Lease may not be terminated prior to December 31,
2001 and Sublessee guarantees performance through that date.

     14.  Interpretations and Meanings. All words used in this Sublease shall
have the same meaning as the words used in the Lease, unless specifically
defined to the contrary in the Sublease.

     15.  Access. Sublessee shall have access to space 24 hours per day, 7 days
per week. Sublessee shall have access to use of HVAC controls after normal
business hours within reasonable usage.

     16.  Current Status. Sublessor represents that as of the date of this
Sublease it has not received notice of any default under the Master Lease, and
that the Master Lease is in full force and effect without modification.
Sublessor further represents that it will not voluntarily surrender the Premises
or terminate the Master Lease without prior consent of the Sublessee.

     17.  Holdover. In the event Sublessee shall wish to extend after the
expiration or earlier termination of the term of this Sublease such tenancy
shall be subject to approval of Sublessor and be for a month-to-month tenancy.
During such tenancy Sublessee agrees to pay Sublessor 100 percent of the rate
payable per Sublease during the last month of the lease term as set forth
herein.

     18.  Quiet Enjoyment. Sublessor covenants that as long as Sublessee shall
pay rent and all other amounts Sublessee shall be required to pay hereunder
within any applicable grace period and shall duly observe, perform, and comply
with all of the terms, covenants and conditions of this Sublease on its part to
be observed, performed, or complied with, Sublease shall subject to all the
terms of the Master Lease and this Sublease, peaceably have, hold and enjoy the
Premises during the Term without malestation or hindrance of Sublessor.

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<PAGE>   5

     IN WITNESS WHEREOF, Sublessor and Sublessee have executed this instrument
as of the date first above written.

                                    SUBLESSOR:

WITNESSES:                          ADVANCED MODULAR SYSTEMS, INC.

/s/                                 By:  /s/ George Levy
----------------------------           -----------------------------------

/s/                                 Its: Chairman
----------------------------            ----------------------------------

                                    SUBLESSEE:

                                    GENOMIC SOLUTIONS INC.
/s/                                 By: /s/ Steven J. Richvalsky
----------------------------           ---------------------------------

----------------------------        Its: Executive Vice President
                                         Chief Financial Officer
                                         Secretary and Treasurer

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<PAGE>   6

CONSENT TO SUBLEASE

     The undersigned, in consideration of the covenants and agreements expressed
in the above and foregoing Sublease, consents to the sublease of the above Lease
from Sublessor to Sublessee above named, subject to the payment of all rent
reserved therein and the performance of all covenants, conditions and terms
therein contained, provided that nothing contained herein shall be construed as
a release of the Sublessor of any obligations, duties or covenants contained in
the Lease.

                                    LANDLORD:

                By:

                                        Printed Name:
                                    Its:

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<PAGE>   7

APPENDIX TO GENOMIC SOLUTIONS, INC. LEASE OF 4370 VARSITY DRIVE

1.  Space Breakdown:

        Cubicle Space                              1650 sq. ft.
        Office & Common Area Space                  600 sq. ft.

        Total                                      2250 sq. ft.

Cubicle space (Cubicles 1 through 12).

Office is one front, windowed offices (Room 17). [All rooms as designated on the
Building Plan, attached and part of this Appendix]. Lessee also has
non-exclusive access to cafeteria, hallways, common rooms such as conference
rooms and toilets, copy room, etc.

Furniture/Accessories

                         Sufficient phones for all space, offices and labs,
                         segregated with reasonable local calls included in base
                         rate

                         Name and Logo on entry door and entrance foyer
                         Furniture, as needed for space

                           Desks

                           Chairs

                           Tables

                           Bookcases

                           Other furniture as may be needed and as available
                           from AMPS

                           Nameplates/GSI on cubicle

/s/ George Levy                     Steven J. Richvalsky
-------------------------------     ---------------------------------------
for AMPS, Inc.  (Chairman)          for Genomic Solutions, Inc.
                                    Executive Vice President
                                    Chief Financial Officer
                                    Secretary and Treasurer

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