Document:

Change in Control Agreement

 Exhibit 10.1 
 RENASANT CORPORATION 
 CHANGE IN CONTROL AGREEMENT

 This Change in Control Agreement (the “Agreement”) is entered into by and between Mike Ross
(“Executive”) and Renasant Corporation, a Mississippi corporation (the “Company”). 
  

	1.	Definitions: 

 1.1
“Affiliate” means one or more subsidiaries or other entities with respect to which the Company owns (within the meaning of Section 425(f) of the Internal Revenue Code of 1986, as amended (the “Code”)) 50% or more of the
total combined voting power of all classes of stock or other equity interests. 
 1.2 “Base Compensation” means
Executive’s annualized base salary. 
 1.3 “Board” means the Board of Directors of the Company.

 1.4 “Cause” means that Executive has: 
  

	 	a.	Committed an intentional act of fraud, embezzlement or theft in the course of his employment or otherwise engaged in any intentional misconduct which is materially
injurious to the Company’s (or an Affiliate’s) financial condition or business reputation; 

  

	 	b.	Committed intentional damage to the property of the Company (or an Affiliate) or committed intentional wrongful disclosure of Confidential Information (as defined
below); 

  

	 	c.	Been indicted for the commission of a felony or a crime involving moral turpitude; 

  

	 	d.	Willfully and substantially refused to perform the essential duties of his position, which has not been cured within 30 days following written notice by the
Company’s Chief Executive Officer; 

  

	 	e.	Intentionally, recklessly or negligently violated any material provision of any code of ethics, code of conduct or equivalent code or policy of the Company or its
Affiliates applicable to him; or 

  

	 	f.	Intentionally, recklessly or negligently violated any material provision of the Sarbanes-Oxley Act of 2002 or any of the rules adopted by the Securities and Exchange
Commission implementing any such provision. 

 No act or failure to act on the part of Executive will be deemed
“intentional” if it was due primarily to an error in judgment or negligence (but not gross negligence), but will be deemed “intentional” only if done or omitted to be done by Executive not in good faith and without reasonable
belief that his action or omission was in the best interest of the Company or an Affiliate. 
 1.5 “Change In
Control” means and shall be deemed to occur upon a Change in Equity Ownership, a Change in Effective Control, a Change in the Ownership of Assets or a Change by Merger. For this purpose: 
  

	 	a.	A “Change in Equity Ownership” means that a person or group acquires, directly or indirectly in accordance with Code Section 318, more than 50% of the
aggregate fair market value or voting power of the capital stock of the Company, including for this purpose capital stock previously acquired by such person or group; provided, however, that a change in Equity Ownership shall not be deemed to occur
hereunder if, at the time of any such acquisition, such person or group owns more than 50% of the aggregate fair market value or voting power of the Company’s capital stock. 

  

	 	b.	A “Change in Effective Control” means that (i) a person or group acquires (or has acquired during the immediately preceding 12-month period ending on the
date of the most recent acquisition by such person or group), directly or indirectly in accordance with Code Section 318, ownership of the capital stock of the Company possessing 35% or more of the total voting power of the Company, or
(ii) a majority of the members of the Board of Directors of the Company is replaced during any 12-month period, whether by appointment or election, without endorsement by a majority of the members of the Board prior to the date of such
appointment or election. 

	 	c.	A “Change in the Ownership of Assets” means that any person or group acquires (or has acquired in a series of transactions during the immediately preceding
12-month period ending on the date of the most recent acquisition) all or substantially all of the assets of the Company. 

  

	 	d.	A “Change by Merger” means that the Company shall consummate a merger or consolidation or similar transaction with another corporation or entity, unless as a
result of such transaction, more than 50% of the then outstanding voting securities of the surviving or resulting corporation or entity shall be owned in the aggregate by the former shareholders of the Company and the voting securities of the
surviving or resulting corporation or entity are owned in substantially the same proportion as the common stock of the Company was beneficially owned before such transaction. 

 The Board shall promptly certify to Executive whether a Change in Control has occurred hereunder, which certification shall not be unreasonably withheld.

 1.6 “Code” means the Internal Revenue Code of 1986, as amended. 
 1.7 “Good Reason” means that in connection with a Change in Control: 
  

	 	a.	Executive’s Base Compensation in effect immediately before such change is materially diminished; 

  

	 	b.	Executive’s authority, duties or responsibilities are materially diminished from those performed by Executive prior to the Change in Control; or

  

	 	c.	There is a material change in the office or business location at which Executive is required to perform services, but in no event less than a change outside the 30-mile
radius of the location he was assigned to prior to the Change in Control. 

 No event or condition described in
this Section 1.7 shall constitute Good Reason unless (a) Executive provides to the Chief Executive Officer notice of his objection to such event or condition not more 60 days after Executive first learns of such event, which notice shall
be delivered in writing, (b) such event or condition is not promptly corrected by the Company, but in no event later than 30 days after receipt of such notice, and (c) Executive resigns his employment with the Company and its Affiliates
not more than 60 days following the expiration of the 30-day period described in subparagraph (b) hereof. 
 1.8
“Incentive Bonus” means the amount paid or payable to Executive under the Company’s Performance Based Rewards Plan or similar annual cash bonus arrangement. 
 1.9 “Termination of employment,” “separation from service,” and words of similar import used herein shall mean
the later of the date on which (a) an Executive’s employment with the Company and its Affiliates ceases, or (b) the Company and such Executive reasonably anticipate that Executive will perform no further services for the Company and
it’s Affiliates, whether as a common law employee or independent contractor. Notwithstanding the foregoing, Executive may be deemed to incur a separation from service hereunder if he continues to provide services to the Company or an Affiliate,
provided such services are not more than 20% of the average level of services performed, whether as an employee or independent contractor, during the immediately preceding 36-month period. 
  

	2.	Change in Control Benefits: 

 2.1 Termination In Connection With a Change in Control. If Executive’s employment is involuntarily terminated by the Company, without Cause, or Executive terminates his employment with the Company for Good Reason, either
occurring during the 24-month period following a Change in Control (Executive’s “Eligible Termination”), the Company shall pay or provide to Executive the following: 
  

	 	a.	Executive’s Incentive Bonus with respect to the Company’s completed fiscal year immediately preceding Executive’s Eligible Termination, to the extent
such amount has not been paid as of the change; such amount shall be paid on the payment date generally applicable to such bonus. 

  

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	 	b.	If Executive and/or his dependants timely elect to continue group medical coverage in accordance with Code Section 4980B with respect to the group medical plan
sponsored by the Company or an Affiliate (excluding for this purpose any health flexible spending account described in Code Sections 125 and 105(h)), the Company shall pay to Executive the amount of the continuation coverage premium for the same
type and level of coverage received by Executive and his electing dependants immediately prior to Executive’s Eligible Termination for the period such coverage is actually provided in accordance with Code Section 4980B, but not in excess
of 18 months; payment hereunder shall be made on the first business day of each calendar month following Executive’s timely coverage election, and, to facilitate the payment of Executive’s group medical plan premiums, may, in the
discretion of the Company, be remitted directly by the Company to such plan or other appropriate person. 

  

	 	c.	Vesting shall be accelerated, any restrictions shall lapse, and all performance objectives shall be deemed satisfied as to any outstanding grant or award made to
Executive under the Company’s 2001 Long-Term Incentive Compensation Plan, as the same may be amended, restated or superseded from time to time. 

  

	 	d.	The Company shall pay to Executive an additional amount equal to 2.00 times the aggregate of Executive’s (i) Base Compensation in effect prior to such change,
and (ii) average Incentive Bonus paid with respect to the two whole calendar years preceding such change; the amount determined hereunder shall be paid in the form of a single-sum not more than 30 days following such change.

 2.2 Limitation on Payments. If the aggregate present value of all payments and benefits due to Executive
under this Agreement and any other payment or benefit due to Executive from the Company or an Affiliate or any successor thereto on account of a Change in Control (the “Aggregate Payments”) would be subject to the excise tax imposed by
Code Section 4999, such payments or benefits shall be reduced by the minimum amount necessary to result in no portion of the Aggregate Payments, so reduced, being subject to such tax. The determination of whether a reduction is required
hereunder shall be made by the Company’s registered independent public accounting firm and shall be binding upon the parties hereto. To the extent practicable, Executive shall be entitled to select the payments or benefits subject to reduction.

 2.3 Specified Employee Delay. In the event the Company determines that Executive is a “specified employee”
within the meaning of Code Section 409A as of his Eligible Termination, then, notwithstanding any provision of this Agreement to the contrary, the Company shall postpone until the first business day of the seventh calendar month following such
termination (the “Delayed Payment Date”) any payment or benefit hereunder which is deemed on account of Executive’s separation from service and not otherwise permitted to be paid or furnished in accordance with the provisions of Code
Section 409A and the guidance promulgated thereunder. Any payment made as of Executive’s Delayed Payment Date shall include the principal amount of all payments suspended between Executive’s Eligible Termination and such date, without
liability for interest or other loss of investment opportunity. 
 2.4 Other Benefits and Payments. Amounts payable or
provided under this Section 2 shall be in lieu of and not in addition to any severance pay or similar post-termination benefit or payment otherwise provided under any severance pay or similar plan, policy or arrangement maintained by the
Company or its Affiliates. Notwithstanding the foregoing, nothing contained herein shall affect the payment or provision of any amount or benefit which the Company and its Affiliates are required by law to pay or provide. 
 2.5 Further Limitation on Payments. As a condition of the receipt of any cash payment hereunder, Executive acknowledges that the
Board retains the discretion to reduce the amount of the benefit to the extent necessary to ensure that all cash benefits paid under this Agreement on account of a Change in Control, when aggregated with similar change in control severance benefits
paid under separate plans, policies and arrangements maintained by the Company and its Affiliates, excluding for this purpose payments made under certain employment agreements between the Company and/or Renasant Bank and certain of their executive
officers, do not exceed a specified amount, which will be determined by the Board in good faith at the time a Change in Control occurs. The purpose of this limit is to ensure that all severance benefits payable on account of a Change in Control will
not be excessive, when considered in the aggregate. If a reduction is required, the Board shall furnish notice to Executive, and, to the extent practicable, the amount of the reduction will be applied on a pro rata basis to all affected executive,
officers and employees. 
  

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	3.	Limitations On Activities: 

 3.1 Consideration for Limitation on Activities. Executive acknowledges that the execution of this Agreement and the payments described herein constitute consideration for the limitations on activities set forth in this
Section 3, the adequacy of which is hereby acknowledged. 
 3.2 Intellectual Property. The parties hereto agree that
the Company owns all Intellectual Property (as defined below) and associated goodwill. Executive agrees to assign, and hereby assigns to the Company, without further consideration or royalty, the ownership of and all rights to such property and
goodwill. The Company shall possess the right to own, obtain and hold in its name any right, registration, or other protection or recordation associated with such Intellectual Property, and Executive agrees to perform, whether during the course of
his employment with the Company or an Affiliate or thereafter, such actions as may be necessary or desirable to transfer, perfect and defend the Company’s ownership or registration of such property. Notwithstanding the generality of the
foregoing, this provision shall not apply to any property for which no equipment, supplies, facilities or information of the Company was used and which was developed entirely during Executive’s own time, unless such property relates to the
business of the Company or an Affiliate or results from any work performed by Executive for the Company or an Affiliate. 
 For
purposes of this Agreement, “Intellectual Property” shall mean all inventions, discoveries, creations, improvements, techniques, trade secrets, products (utility or design), works of authorship or any other intellectual property relating
to any programming, documentation, technology, material, product, service, idea, process, method, plan or strategy concerning the business or interests of the Company and its Affiliates that Executive conceives, develops or delivers, in whole or in
part, during the period of his employment with the Company and its Affiliates. 
 3.3 Confidential Information. Executive
recognizes and acknowledges that during his employment with the Company and it Affiliates, he will have access to confidential, proprietary, non-public information concerning the Company and its Affiliates, which may include, without limitation,
(a) books, records and policies relating to operations, finance, accounting, personnel and management, (b) information related to any business entered into by the Company or an Affiliate, (c) credit policies and practices, databases,
customer lists, information obtained on competitors, and tactics, (d) various other non-public trade or business information, including business opportunities and strategies, marketing, acquisition or business diversification plans, methods and
processes, work product, and (e) selling and operating policies and practices, including without limitation, policies and practices concerning the identity, solicitation, acquisition, management, resale or cancellation of unsecured or secured
credit card accounts, loan or lease accounts or other accounts relating to consumer products and services (collectively, “Confidential Information”). Executive agrees that he will not at any time, either during the course of his employment
or afterwards, make any independent use of, or disclose to any other person or organization any Confidential Information, except as may be expressly authorized by the Company, in the ordinary course of Executive’s employment with the Company
and its Affiliates or as may be required by law or legal process. 
 3.4 Return of Property. Upon his termination of
employment for any reason, Executive or his estate shall promptly return to the Company all of the property of the Company and its Affiliates, including, without limitation, automobiles, equipment, computers, fax machines, portable telephones,
printers, software, credit cards, manuals, customer lists, financial data, letters, notes, notebooks, reports and copies of any of the above and any Confidential Information (as defined in Section 4.3 hereof) that is in the possession or under
the control of Executive. Executive shall provide to the Company written certification that he has complied with the provisions of this Section 3.2 not later than ten days after such termination. 
  

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 3.5 Business Reputation. Executive agrees that during the course of his employment
and at all times thereafter he shall refrain from performing any act, engaging in any conduct or course of action or making or publishing an adverse, untrue or misleading statement which has or may reasonably have the effect of demeaning the name or
business reputation of the Company or its Affiliates or which adversely affects (or may reasonably adversely affect) the best interests (economic or otherwise) of the Company or an Affiliate, except as may be required by law or legal process.

 The Company agrees that during the course of Executive’s employment and thereafter, it shall refrain from performing any
act, engaging in any conduct or course of action or making or publishing an adverse, untrue or misleading statement which has or may reasonably have the effect of demeaning Executive, except as may be required by law or legal process. 
 3.6 Non-Solicitation. Executive agrees that during the Restricted Period (as defined below), he shall not, directly or indirectly,
for his own benefit or on behalf of another or to the Company’s detriment: 
  

	 	a.	Solicit, hire, or offer to hire or participate in the hiring of any of the Company’s or Affiliate’s officers, executives or agents; 

 

	 	b.	Persuade or attempt to persuade in any manner any officer, executive or agent of the Company or an Affiliate to discontinue any relationship with the Company or an
Affiliate; or 

  

	 	c.	Solicit, divert, or attempt to solicit or divert any customer or depositor of the Company or an Affiliate. 

 3.7 Non-Competition. The Executive agrees that he shall not, during the Restricted Period, whether as an executive, officer,
director, shareholder, owner, partner, joint venturer, independent contractor, consultant or in another managerial capacity, engage in the Banking Business in the Restricted Area. For purposes of this Section 3.7, the term “Banking
Business” shall mean the management and/or operation of a retail bank or other financial institution, securities brokerage, or insurance agency or brokerage. The term “Restricted Area” shall mean within the 100-mile radius of any
geographic location in which the Company or an Affiliate has an office on the date of Executive’s termination of employment with the Company and its Affiliates. 
 3.8 Reformation. The parties agree that each of the prohibitions set forth herein is intended to constitute a separate restriction. Accordingly, should any such prohibition be declared invalid or
unenforceable, such prohibition shall be deemed severable from and shall not affect the remainder thereof. The parties further agree that each of the foregoing restrictions is reasonable in both time and geographic scope. If and to the extent a
court of competent jurisdiction or an arbitrator, as the case may be, determines that any of the restrictions or covenants set forth in this Agreement are unreasonable, then it is the intention of the parties that such restrictions be enforced to
the fullest extent that such court or arbitrator deems reasonable and that this Agreement shall be reformed to the extent necessary to permit such enforcement. 
 3.9 Remedies. In the event of a breach or threatened breach by Executive of the provisions of this section hereof, Executive agrees that the Company shall be entitled to a temporary restraining
order or a preliminary injunction (without the necessity of posting bond in connection therewith) and that any additional payments or benefits due to Executive may be suspended, canceled, or forfeited, in the sole discretion of the Company. Nothing
herein shall be construed as prohibiting the Company from pursuing any other remedy available to it for such breach or threatened breach, including the recovery of damages from Executive. 
 3.10 Survival. Executive acknowledges that the proscriptions set forth in this Section 3 shall survive the termination of his
employment with the Company and its Affiliates and/or the termination or expiration of this Agreement. 
 3.11
Definition. As used herein, the term “Restricted Period” shall mean the period commencing upon Executive’s termination of employment for any reason and ending (a) two years after Executive’s Eligible Termination, or
(b) six months thereafter, in all other cases. 
  

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	4.	Miscellaneous: 

 4.1.
Not an Employment Agreement. Nothing contained herein shall be deemed to constitute an employment agreement between Executive and the Company or any Affiliate. The parties expressly intend that this Agreement shall not be deemed to modify
Executive’s “at will” employment status. 
 4.2 Mitigation Not Required. As a condition of any payment
hereunder, Executive shall not be required to mitigate the amount of such payment by seeking other employment or otherwise, nor will any profits, income, earnings or other benefits from any source whatsoever create any mitigation, offset, reduction
or any other obligation on the part of Executive under this Agreement. 
 4.3 Enforcement of This Agreement. In addition
to the Company’s equitable remedies provided under Section 3.9 hereof, which need not be exclusively resolved by arbitration, in the event that any legal dispute arises in connection with, relating to, or concerning this Agreement, or in
the event of any claim for breach or violation of any provision of this Agreement, Executive agrees that such dispute or claim will be resolved by arbitration. Any such arbitration proceeding shall be conducted in accordance with the rules of the
American Arbitration Association (“AAA”). Any such dispute or claim will be presented to a single arbitrator selected by mutual agreement of the Executive and the Company (or the arbitrator will be selected in accordance with the rules of
the AAA). All determinations of the arbitrator will be final and biding upon the Executive and the Company. Except as provided in Section 5.3 hereof, each party to the arbitration proceeding will bear its own costs in connection with such
arbitration proceedings, except that unless otherwise paid by the Company in accordance with such section, the costs and expenses of the arbitrator will be divided evenly between the parties. The venue for any arbitration proceeding and for any
judicial proceeding related to this arbitration provision (including a judicial proceeding to enforce this provision) will be in Tupelo, Mississippi. 
 4.4 Attorneys’ Fees. In the event any dispute in connection with this Agreement arises with respect to obligations of Executive or the Company that were required prior to the occurrence of a
Change in Control, all costs, fees and expenses, including attorneys’ fees, of any litigation, arbitration or other legal action in connection with such matters in which Executive substantially prevails, shall be borne by, and be the obligation
of, the Company. 
 After a Change in Control has occurred, Executive shall not be required to incur legal fees and the related
expenses associated with the interpretation, enforcement or defense of Executive’s rights under this Agreement by arbitration, litigation or otherwise. Accordingly, if following a Change in Control, the Company has failed to comply with any of
its obligations under this Agreement or the Company or any other person takes or threatens to take any action to declare this Agreement void or unenforceable or in any way reduce the possibility of collecting the amounts due hereunder, or institutes
any litigation or other action or proceeding designed to deny or to recover from Executive the benefits provided or intended to be provided under this Agreement, Executive shall be entitled to retain counsel of Executive’s choice, at the
expense of the Company, to advise and represent Executive in connection with any such interpretation, enforcement or defense, including without limitation, the initiation or defense of any litigation, arbitration or other legal action, whether by or
against the Company or any director, officer, stockholder or other person affiliated with the Company, in any jurisdiction. The Company shall pay and be solely financially responsible for any and all attorneys’ and related fees and expenses
incurred by Executive in connection with any of the foregoing, without regard to whether Executive prevails, in whole or in part. 
 In no event shall Executive be required to reimburse the Company for any of the costs and expenses incurred by the Company relating to arbitration, litigation or other legal action in connection with this Agreement. 
 Executive shall claim payment or reimbursement of attorneys’ fees hereunder not later than 90 days after the end of the calendar year
in which such claim arises hereunder. The Company shall promptly pay or reimburse such fees, but in no event later than 90 days after it receives proper and complete evidence thereof. 
 4.5 No Set-Off. There shall be no right of set-off or counterclaim in respect of any claim, debt or obligation against any payment to
Executive provided for in this Agreement. 
  

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 4.6 Assistance with Litigation. For a period of two years after Executive’s
termination of employment with the Company and its Affiliates, Executive will furnish such information and proper assistance as may be reasonably necessary in connection with any litigation in which the Company (or an Affiliate) is then or may
become involved, without the payment of a fee or charge, except reimbursement of his direct expenses. 
 4.7 Headings.
Section and other headings contained in this Agreement are for reference purposes only and shall not affect in any way the meaning or interpretation of this Agreement. 
 4.8 Entire Agreement. This Agreement constitutes the final and complete understanding and agreement among the parties hereto with respect to the subject matter hereof, and there are no other
agreements, understandings, restrictions, representations or warranties among the parties other than those set forth herein. Executive acknowledges that this Agreement replaces, in its entirety, the Prior Agreement and extinguishes, in their
entirety, the Company’s obligations thereunder. 
 4.9 Amendments. This Agreement may be amended or modified at any
time in any or all respects, but only by an instrument in writing executed by the parties hereto. 
 4.10 Choice of Law.
The validity of this Agreement, the construction of its terms, and the determination of the rights and duties of the parties hereto shall be governed by and construed in accordance with the internal laws of the State of Mississippi applicable to
contracts made to be performed wholly within such state, without regard to the choice of law provisions thereof. 
 4.11
Notices. All notices and other communications under this Agreement must be in writing and will be deemed to have been duly given when (a) delivered by hand, (b) sent by facsimile to a facsimile number given below, provided that a copy
is sent by a nationally recognized overnight delivery service (receipt requested), or (c) when received by the addressee, if sent by a nationally recognized overnight delivery service (receipt requested), in each case as follows: 
  

			
	If to Executive:	  	Most Recent Address
		  	on File with the Company
		
	If to the Company:	  	Renasant Corporation
		  	209 Troy Street
		  	Tupelo, MS 38804
		  	Attention: Chief Executive Officer

 or to such other
addresses as a party may designate by notice to the other party. 
 4.12 Successors; Assignment. This Agreement is
personal to Executive and shall not be assigned by him or her without the prior written consent of the Company. This Agreement will inure to the benefit of and be binding upon the Company, its Affiliates, successors and assigns, including, without
limitation, any person, partnership, company, corporation or other entity that may acquire substantially all of the Company’s assets or business or with or into which the Company may be liquidated, consolidated, merged or otherwise combined.
This Agreement will inure to the benefit of and be binding upon Executive, his heirs, estate, legatees and legal representatives. Any payment due to Executive shall be paid to his surviving spouse or estate after his death. 
 4.13 Severability. Each provision of this Agreement is intended to be severable. In the event that any one or more of the provisions
contained in this Agreement shall for any reason be held to be invalid, illegal or unenforceable, the same shall not affect the validity or enforceability of any other provision of this Agreement, but this Agreement shall be construed as if such
invalid, illegal or unenforceable provision was not contained herein. Notwithstanding the foregoing, however, no provision shall be severed if it is clearly apparent under the circumstances that the parties would not have entered into this Agreement
without such provision. 
 4.14 Withholding. As a condition of any payment hereunder the Company or an Affiliate shall
withhold any federal, state or local taxes required to be withheld. 
  

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 4.15 Survival. Notwithstanding anything herein to the contrary, the rights and
obligations of the Company and its Affiliates and Executive under Sections 3.2, 4, and 5 hereof shall remain operative and in full force and effect regardless of the expiration or termination of this Agreement or the termination of Executive’s
employment hereunder for any reason. 
 4.16 Waiver. The failure of either party to insist in any one or more instances
upon performance of any terms or conditions of this Agreement will not be construed as a waiver of future performance of any such term, covenant, or condition and the obligations of either party with respect to such term, covenant or condition will
continue in full force and effect. 
 4.17 Term; Expiration and Termination. This Agreement shall be effective as of
January 1, 2009, and shall, unless earlier terminated as provided herein, terminate as of the first anniversary hereof; provided, that on the first anniversary of this Agreement and on each subsequent anniversary hereof, this Agreement shall be
automatically extended for an additional one-year term unless the Company gives Executive notice of its intent not to renew this Agreement at least 60 days prior to the end of the initial term or any renewal term hereof. This Agreement shall be
earlier terminated and the Company’s obligations hereunder shall cease upon Executive’s death, disability or termination of employment with the Company and its Affiliates for any reason, except as provided in Section 2.1 hereof. The
Company may earlier terminate this Agreement for Cause, notwithstanding that Executive’s employment with the Company has not been terminated. 
 This Agreement is executed in multiple counterparts as of the dates set forth below, each of which shall be deemed an original, to be effective as designated above. 
  

									
	Renasant Corporation:	 		 	Executive:
				
	By:	 	 /s/ E. Robinson McGraw
	 		 	 /s/ Michael D. Ross

		 	E. Robinson McGraw	 		 		 	
		 	Chief Executive Officer	 		 		 	
					
	Date:	 	 January 21, 2009
	 		 	Date:	 	 January 20, 2009

  

 8Warrant to Purchase Stock Agreement

 Exhibit 4.19 
 THIS WARRANT AND THE SECURITIES ISSUABLE UPON EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY STATE SECURITIES LAW,
AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED, HYPOTHECATED OR OTHERWISE DISPOSED OF OR EXERCISED UNLESS (I) A REGISTRATION STATEMENT REGISTERING SUCH SECURITIES UNDER THE SECURITIES ACT AND APPLICABLE STATE SECURITIES LAWS SHALL HAVE
BECOME EFFECTIVE, OR (II) THE CORPORATION HAS RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO IT THAT SUCH TRANSFER MAY LAWFULLY BE MADE WITHOUT REGISTRATION UNDER THE SECURITIES ACT OR QUALIFICATION UNDER APPLICABLE STATE SECURITIES LAWS, OR
(III) SUCH SECURITIES ARE SOLD PURSUANT TO RULE 144. 
 AN INVESTMENT IN THESE SECURITIES INVOLVES A HIGH DEGREE OF RISK. HOLDERS MUST RELY ON
THEIR OWN ANALYSIS OF THE INVESTMENT AND ASSESSMENT OF THE RISKS INVOLVED. 
 ARCA BIOPHARMA, INC.

 WARRANT TO PURCHASE COMMON STOCK 
  

			
	No. CW – 7	  	October 18, 2009

 This
certifies that, for value received, BioMed Realty, L.P., with its principal office at 17190 Bernardo Center Drive, San Diego, California 92128, or its permitted assigns (the “Holder”), is entitled to subscribe for and purchase at
the Exercise Price (as defined below) from ARCA biopharma, Inc., a Delaware corporation, with its principal office at 8001 Arista Place, Suite 200, Broomfield, Colorado 80021 (the “Corporation”), up to a number of Exercise Shares
(as defined below), upon the terms and subject to the adjustments as provided herein. 
 This Warrant is being issued pursuant
to the terms of the Lease Termination and Warrant Purchase Agreement, dated September 18, 2009 (the “Lease Termination and Warrant Purchase Agreement”) by and among the Corporation, BMR-201 Industrial Road LLC, a Delaware
limited liability company, and the Holder. Capitalized terms used herein but not otherwise defined shall have the meanings given to them in the Lease Termination and Warrant Purchase Agreement. 
 1. Definitions. As used herein, the following terms shall have the following respective meanings: 
 (a) “Exercise Period” shall mean the time period commencing with the date of this Warrant and ending on the earlier
of (i) the date that is seven (7) years from date of this Warrant, or (ii) the commencement of any liquidation, bankruptcy, insolvency, dissolution or winding-up (or the occurrence of any analogous proceeding) of the Corporation.

 (b) “Exercise Price” shall mean $3.82 per share subject to adjustment pursuant to the terms herein,
including Section 5 below. 
 (c) “Exercise Shares” shall mean 130,890 shares of common stock of
the Corporation (the “Common Stock”) subject to adjustment pursuant to the terms herein, including Section 5 below. 

 2. EXERCISE OF WARRANT.

 2.1 IN GENERAL. The rights represented by this Warrant may be exercised in whole or in
part at any time during the Exercise Period, by delivery of the following to the Corporation at its address set forth above (or at such other address as it may designate by notice in writing to the Holder): 
 A. an executed Notice of Exercise in the form attached hereto; 
 B. payment of the Exercise Price either (i) in cash or by check, or (ii) pursuant to Section 2.2 below; and 
 C. this Warrant. 
 Upon the exercise of the rights represented by this Warrant, a certificate or certificates for the Exercise Shares so purchased, registered in the name of the Holder or persons affiliated with the Holder, if the Holder so designates, shall
be issued and delivered to the Holder as soon as practicable after the rights represented by this Warrant shall have been so exercised. 
 The person in whose name any certificate or certificates for Exercise Shares are to be issued upon exercise of this Warrant shall be deemed to have become the holder of record of such shares on the date
on which this Warrant was surrendered and payment of the Exercise Price was made, irrespective of the date of delivery of such certificate or certificates, except that, if the date of such surrender and payment is a date when the stock transfer
books of the Corporation are closed, such person shall be deemed to have become the holder of such shares at the close of business on the next succeeding date on which the stock transfer books are open. In the event that this Warrant is exercised in
respect of fewer than all of the Exercise Shares issuable on such exercise at any time prior to the date of expiration of this Warrant, a new certificate evidencing the remaining Warrant will be issued, in a form substantially identical hereto, in
the name of the Holder, and delivered to the Holder or to another person that the Holder has designated for delivery as soon as practicable. 
 This Warrant shall be null and void, and the rights represented hereby shall automatically expire immediately upon the expiration of the Exercise Period. 
 2.2 Net Exercise. Notwithstanding any provisions herein to the contrary, if the fair market value of one share of the
Corporation’s Common Stock is greater than the Exercise Price (at the date of calculation as set forth below), in lieu of exercising this Warrant by payment of cash, the Holder may elect to receive shares equal to the value (as determined
below) of this Warrant (or the portion thereof being canceled) by surrender of this Warrant at the principal office of the Corporation together with the properly endorsed Notice of Exercise, in which event the Corporation shall issue to the Holder a
number of shares of Common Stock computed using the following formula: 
  

			
	X =	  	Y (A-B)
		  	 A

 Where: 
  

			
	X =	  	the number of shares of Common Stock to be issued to the Holder
		
	Y =	  	the number of shares of Common Stock purchasable under the Warrant or, if only a portion of the Warrant is being exercised, the portion of the Warrant being canceled (at the date of
such calculation)
		
	A =	  	the fair market value of one share of the Corporation’s Common Stock (at the date of such calculation)
		
	B =	  	Exercise Price (as adjusted to the date of such calculation)

 For purposes of the above calculation, for so long as the Corporation’s Common Stock is traded in a public market, the fair market value of each share of Common Stock shall be the closing price of a share of Common Stock for the
business day immediately before the day the Holder delivers its Notice of Exercise to the Corporation. If the Corporation’s Common Stock is not traded in a public market, the fair market value of one share of Common Stock shall be determined by
the Corporation’s Board of Directors in good faith. 
 3. REPRESENTATIONS, WARRANTIES
AND COVENANTS OF THE CORPORATION. The Corporation hereby represents and covenants to the Holder as of the date hereof, and with respect to Sections 3.3 and 3.5 for so
long as the Holder holds the Warrant or any Exercise Shares, as follows: 
 3.1 Covenants as to Exercise Shares. The
Corporation covenants and agrees that all Exercise Shares that may be issued upon the exercise of the rights represented by this Warrant will, upon issuance, be validly issued and outstanding, fully paid and nonassessable, and free from all taxes,
liens and charges with respect to the issuance thereof. The Corporation further covenants and agrees that the Corporation shall at all times during the Exercise Period have authorized and reserved, free from preemptive rights, a sufficient number of
shares of its Common Stock to provide for the exercise of the rights represented by this Warrant. 
 3.2 Notices of Record
Date. In the event of any taking by the Corporation of a record of the holders of any class of securities for the purpose of determining the holders thereof who are entitled to receive any dividend (other than a cash dividend which is the same
as cash dividends paid in previous quarters) or other distribution, the Corporation shall mail to the Holder, at least ten (10) days prior to the date specified herein, a notice specifying the date on which any such record is to be taken for
the purpose of such dividend or distribution. 
 3.3 Health Care / Lodging Facilities. The Corporation does not operate
or manage any health care facilities (including a congregate care facility or assisted living facility) or lodging facilities or provide any person, under a franchise, license or otherwise, rights to any brand name under which any lodging facility
or health care facility is operated. 
 3.4 Percentage of Outstanding Stock. As of the date hereof, the Exercise Shares
for which this Warrant may be exercised in full represent less than five percent (5.0%) of the voting interest and less than five percent (5.0%) of the value of the outstanding stock of the Corporation. 

 3.5 Notification. Upon the written request of the Holder, the Corporation shall,
within five (5) days confirm in writing to the Holder whether the Exercise Shares for which this Warrant may be exercised in full constitute greater than five percent (5.0%) of the voting interest and/or greater than five percent
(5.0%) of the value of the outstanding stock of the Corporation. 
 4. REPRESENTATIONS,
WARRANTIES AND COVENANTS OF THE OF HOLDER. 
 4.1 Acquisition of Warrant for Personal Account. The Holder represents and warrants that it is acquiring the Warrant solely for his, her or its account for investment and not with a view to or for
sale or distribution of said Warrant or any part thereof, other than potential transfers between affiliates. The Holder also represents that the entire legal and beneficial interests of the Warrant and Exercise Shares the Holder is acquiring is
being acquired for, and will be held for, his, her or its account only. 
 4.2 Securities Are Not Registered. 

(a) The Holder understands that the Warrant and the Exercise Shares have not been registered under the Securities Act of 1933, as
amended (the “Act”) on the basis that no distribution or public offering of the stock of the Corporation is to be effected. The Holder realizes that the basis for the exemption may not be present if, notwithstanding his, her or its
representations, the Holder has a present intention of acquiring the securities for a fixed or determinable period in the future, selling (in connection with a distribution or otherwise), granting any participation in, or otherwise distributing the
securities. The Holder has no such present intention. 
 (b) The Holder is an “accredited investor” within the
meaning of Regulation D promulgated under the Act. 
 (c) The Holder recognizes that the Warrant and the Exercise Shares
must be held indefinitely unless they are subsequently registered under the Act or an exemption from such registration is available. 
 (d) The Holder is aware of Rule 144 adopted under the Act and the conditions of permitted sales in reliance thereof. 
 4.3 Disposition of Warrant and Exercise Shares. The Holder further agrees not to make any disposition of all or any part of the Warrant or Exercise Shares in any event unless and until: 
 (a) The Corporation shall have received a letter secured by the Holder from the Securities and Exchange Commission stating that no
action will be recommended to the Commission with respect to the proposed disposition; or 
 (b) There is then in effect
a registration statement under the Act covering such proposed disposition and such disposition is made in accordance with said registration statement; or 
 (c) The Holder shall have notified the Corporation of the proposed disposition and shall have furnished the Corporation with a statement of the circumstances surrounding the proposed disposition;
provided, however, that such statement will not be required if the disposition is permitted under Rule 144 of the Act, except in unusual circumstances. 

 5. ADJUSTMENT OF EXERCISE
PRICE AND EXERCISE SHARES; EFFECT OF ORGANIC CHANGES; CUTBACKS 
 5.1 Adjustment of Exercise Price and/or Exercise Shares. In the event of changes in the outstanding capital stock of the Corporation
by reason of stock dividends, splits, recapitalizations, reclassifications, combinations or exchanges of shares, separations, reorganizations, liquidations, or the like, the number and class of shares available under the Warrant in the aggregate and
the Exercise Price shall be correspondingly adjusted to give the Holder of the Warrant, on exercise for the same aggregate Exercise Price, the total number, class, and kind of shares as the Holder would have owned had the Warrant been exercised
immediately prior to the event and had the Holder continued to hold such shares until after the event requiring adjustment. The Corporation will provide prompt written notice to the Holder describing the change and the corresponding adjustment of
the Exercise Price or number of Exercise Shares subject to this Warrant made pursuant to this section. 
 5.2 Reorganization,
Reclassification, Consolidation, Merger or Sale. If any recapitalization, reclassification or reorganization of the capital stock of the Corporation, or any consolidation or merger of the Corporation with another corporation, or the sale of all
or substantially all of its assets or other transaction shall be effected in such a way that holders of the Corporation’s Common Stock shall be entitled to receive stock, securities, or other assets or property, including, without limitation,
upon conversion of such Common Stock (an “Organic Change”), then, as a condition of such Organic Change, lawful and adequate provisions shall be made by the Corporation whereby the Holder hereof shall thereafter have the right to
purchase and receive (in lieu of the shares of the Common Stock of the Corporation immediately theretofore purchasable and receivable upon the exercise of the rights represented hereby) such shares of stock, securities or other assets or
property as may be issued or payable with respect to or in exchange for a number of outstanding shares of such Common Stock equal to the number of shares of such stock immediately theretofore purchasable and receivable upon the exercise of the
rights represented hereby. In the event of any Organic Change, appropriate provision shall be made by the Corporation with respect to the rights and interests of the Holder of this Warrant to the end that the provisions hereof (including, without
limitation, provisions for adjustments of the Exercise Price and of the number of shares purchasable and receivable upon the exercise of this Warrant) shall thereafter be applicable, in relation to any shares of stock, securities or assets
thereafter deliverable upon the exercise hereof and following such Organic Change the Corporation or its successor shall promptly issue to Holder an amendment to this Warrant reflecting such adjustments. 
 5.3 Certain Events. If any change in the outstanding Common Stock of the Corporation or any other event occurs as to which the other
provisions of this Section 5 are not strictly applicable or if strictly applicable would not fairly protect the purchase rights of the Holder of the Warrant in accordance with such provisions, then the Board of Directors of the Corporation
shall make, in good faith, an adjustment in the number and class of shares available under the Warrant, the Exercise Price or the application of such provisions, so as to protect such purchase rights as aforesaid. The adjustment shall be such as to
give the Holder of the Warrant upon exercise for the same aggregate Exercise Price the total number, class and kind of shares as he would have owned had the Warrant been exercised prior to the event and had he continued to hold such shares until
after the event requiring adjustment. The Corporation will provide prompt written notice to the Holder describing the change and the corresponding adjustment of the Exercise Price or number of Exercise Shares subject to this Warrant made pursuant to
this section. 

 6. FRACTIONAL SHARES. No
fractional shares shall be issued upon the exercise of this Warrant as a consequence of any adjustment pursuant hereto. All Exercise Shares (including fractions) issuable upon exercise of this Warrant may be aggregated for purposes of determining
whether the exercise would result in the issuance of any fractional share. If, after aggregation, the exercise would result in the issuance of a fractional share, the Corporation shall, in lieu of issuance of any fractional share, pay the Holder
otherwise entitled to such fraction a sum in cash equal to the product resulting from multiplying the then current fair market value of an Exercise Share by such fraction. 
 7. NO STOCKHOLDER RIGHTS. This Warrant in and of itself shall not entitle the Holder to
any voting rights or other rights as a stockholder of the Corporation. 
 8. TRANSFER OF
WARRANT. Subject to applicable laws and any restrictions on transfer set forth in this Warrant, this Warrant and all rights hereunder are transferable, by the Holder in person or by duly authorized attorney, upon delivery of this
Warrant and the form of assignment attached hereto to any transferee designated by Holder. 
 9. LOST,
STOLEN, MUTILATED OR DESTROYED WARRANT. The Corporation covenants to the Holder that, upon receipt of evidence reasonably satisfactory to the Corporation
of the loss, theft, destruction or mutilation of this Warrant or any stock certificate and, in the case of any such loss, theft or destruction, upon receipt of an indemnity reasonably satisfactory to the Corporation, or in the case of any such
mutilation, upon surrender and cancellation of such Warrant or stock certificate, the Corporation will make and deliver a new Warrant or stock certificate, of like tenor, in lieu of the lost, stolen, destroyed or mutilated Warrant or stock
certificate. 
 10. NOTICES, ETC. Any notice required or permitted under this Warrant shall
be given in writing and shall be deemed effectively given: (a) upon personal delivery to the party to be notified, (b) when sent by confirmed facsimile if sent during normal business hours of the recipient; if not, then on the next
business day, (c) five (5) business days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one (1) business day after deposit with a nationally recognized overnight courier,
specifying next day delivery, with written verification of receipt. All communications shall be sent to (i) the Corporation at the address set forth above, Attention: Chief Executive Officer and General Counsel; or to (ii) the Holder at
his, her or its address set forth above, or at such other address as any such party may designate by ten (10) days advance written notice to the other parties hereto. 
 11. ACCEPTANCE. Receipt of this Warrant by the Holder shall constitute acceptance of and
agreement to all of the terms and conditions contained herein. 
 12. GOVERNING
LAW. This Warrant and all rights, obligations and liabilities hereunder shall be governed and construed under the laws of the State of Colorado in all respects as such laws are applied to agreements
among Colorado residents entered into and performed entirely within Colorado, without giving effect to conflict of law principles thereof. The Corporation and Holder agree that any action brought by any party under or in relation to this Warrant,
including without limitation to interpret or enforce any provision of this Warrant, shall be brought in, and each agrees to and does hereby submit to the jurisdiction and venue of, any state or federal court located in the County of Denver,
Colorado. 
 [Signature Page Follows] 

 IN WITNESS WHEREOF, the
Corporation has caused this Warrant to be executed by its duly authorized officer as of October 18, 2009. 
  

			
	ARCA BIOPHARMA, INC.
		
	By:	 	 /s/ Christopher D. Ozeroff

			
	Print Name:	 	 Christopher D. Ozeroff

			
	Title:	 	 EVP Business Development and General Counsel

 NOTICE OF EXERCISE 
  

					
	TO:	  	ARCA biopharma, Inc.
		  	8001 Arista Place, Suite 200
		  	Broomfield, CO 80021
		  	Attention:	  	Chief Executive Officer and General Counsel

 (1)  The undersigned hereby elects to purchase              shares of the Common Stock of ARCA biopharma, Inc. (the “Corporation”) pursuant to the
terms of the attached Warrant, and tenders herewith payment of the exercise price in full, together with all applicable transfer taxes, if any. 
 The undersigned hereby elects to purchase              shares of the Common Stock of the Corporation pursuant to the terms of the
net exercise provisions set forth in Section 2.2 of the attached Warrant, and shall tender payment of all applicable transfer taxes, if any. 
 (2) Please issue a certificate or certificates representing said shares of Common Stock in the name of the undersigned or in such other name as is specified below: 
  

					
	  
	 		  	
	(Name)	 		  	
			
	  
	 		  	
			
	  
	 		  	
	(Address)	 		  	
			
	  
	 		  	  

	(Date)	 		  	(Signature)
			
		 		  	  

		 		  	(Print name)

 ASSIGNMENT FORM 
 (To assign the foregoing Warrant, execute this form and supply required 
 information. Do not use this form to purchase shares.) 
 FOR
VALUE RECEIVED, the foregoing Warrant and all rights evidenced thereby are hereby assigned to 
  

			
	Name:	 	  

			
	(Please Print)	 	

			
		
	Address:	 	  

			
	(Please Print)	 	

													
							
	Dated:	 	  
	 		 		 		 		 	

			
		
	Holder’s	 	
	Signature:	 	  

		
	Holder’s	 	
	Address:	 	  

 NOTE: The signature to this Assignment Form must correspond with the name as it appears on the face of the Warrant, without alteration or enlargement or any change whatsoever. Officers of
corporations and those acting in a fiduciary or other representative capacity should file proper evidence of authority to assign the foregoing Warrant.

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