Document:

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                                                                  Exhibit 10.28

                                 NITROMED, INC.

                        Incentive Stock Option Agreement
          Granted Under Amended and Restated 2003 Stock Incentive Plan

1.   GRANT OF OPTION.

     This agreement evidences the grant by NitroMed, Inc., a Delaware
corporation (the "Company"), on , 200[ ] (the "Grant Date") to [ ], an employee
of the Company (the "Participant"), of an option to purchase, in whole or in
part, on the terms provided herein and in the Company's Amended and Restated
2003 Stock Incentive Plan (the "Plan"), a total of [ ] shares (the "Shares") of
common stock, $.01 par value per share, of the Company ("Common Stock") at $[ ]
per Share. Unless earlier terminated, this option shall expire at 5:00 p.m.,
Eastern time, on [_______] (the "Final Exercise Date").

     It is intended that the option evidenced by this agreement shall be an
incentive stock option as defined in Section 422 of the Internal Revenue Code of
1986, as amended, and any regulations promulgated thereunder (the "Code").
Except as otherwise indicated by the context, the term "Participant", as used in
this option, shall be deemed to include any person who acquires the right to
exercise this option validly under its terms.

2.   VESTING SCHEDULE.

     This option will become exercisable ("vest") as to    % of the original
number of Shares on the [first] anniversary of the Grant Date and as to an
additional    % of the original number of Shares at the end of each
successive [three-month]period following the first anniversary of the Grant
Date until the [fourth]anniversary of the Grant Date.

     The right of exercise shall be cumulative so that to the extent the option
is not exercised in any period to the maximum extent permissible it shall
continue to be exercisable, in whole or in part, with respect to all Shares for
which it is vested until the earlier of the Final Exercise Date or the
termination of this option under Section 3 hereof or the Plan.

3.   EXERCISE OF OPTION.

     (a) FORM OF EXERCISE. Each election to exercise this option shall be in
writing, signed by the Participant, and received by the Company at its principal
office, accompanied by this agreement, and payment in full in the manner
provided in the Plan. The Participant may purchase less than the number of
shares covered hereby, provided that no partial exercise of this option may be
for any fractional share.

     (b) CONTINUOUS RELATIONSHIP WITH THE COMPANY REQUIRED. Except as otherwise
provided in this Section 3, this option may not be exercised unless the
Participant, at the time he or she exercises this option, is, and has been at
all times since the Grant Date, an employee or officer of, or consultant or
advisor to, the Company or any parent or subsidiary of the Company as defined in
Section 424(e) or (f) of the Code (an "Eligible Participant").

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     (c) TERMINATION OF RELATIONSHIP WITH THE COMPANY. If the Participant ceases
to be an Eligible Participant for any reason, then, except as provided in
paragraphs (d) and (e) below, the right to exercise this option shall terminate
three months after such cessation (but in no event after the Final Exercise
Date), PROVIDED THAT this option shall be exercisable only to the extent that
the Participant was entitled to exercise this option on the date of such
cessation. Notwithstanding the foregoing, if the Participant, prior to the Final
Exercise Date, violates the non-competition or confidentiality provisions of any
employment contract, confidentiality and nondisclosure agreement or other
agreement between the Participant and the Company, the right to exercise this
option shall terminate immediately upon such violation.

     (d) EXERCISE PERIOD UPON DEATH OR DISABILITY. If the Participant dies or
becomes disabled (within the meaning of Section 22(e)(3) of the Code) prior to
the Final Exercise Date while he or she is an Eligible Participant and the
Company has not terminated such relationship for "cause" as specified in
paragraph (e) below, this option shall be exercisable, within the period of one
year following the date of death or disability of the Participant, by the
Participant (or in the case of death by an authorized transferee), PROVIDED THAT
this option shall be exercisable only to the extent that this option was
exercisable by the Participant on the date of his or her death or disability,
and further provided that this option shall not be exercisable after the Final
Exercise Date.

     (e) DISCHARGE FOR CAUSE. If the Participant, prior to the Final Exercise
Date, is discharged by the Company for "cause" (as defined below), the right to
exercise this option shall terminate immediately upon the effective date of such
discharge. "Cause" shall mean willful misconduct by the Participant or willful
failure by the Participant to perform his or her responsibilities to the Company
(including, without limitation, breach by the Participant of any provision of
any employment, consulting, advisory, nondisclosure, non-competition or other
similar agreement between the Participant and the Company), as determined by the
Company, which determination shall be conclusive. The Participant shall be
considered to have been discharged for "Cause" if the Company determines, within
30 days after the Participant's resignation, that discharge for cause was
warranted.

4.   COMPANY RIGHT OF FIRST REFUSAL.

     (a) NOTICE OF PROPOSED TRANSFER. If the Participant proposes to sell,
assign, transfer, pledge, hypothecate or otherwise dispose of, by operation of
law or otherwise (collectively, "transfer") any Shares acquired upon exercise of
this option, then the Participant shall first give written notice of the
proposed transfer (the "Transfer Notice") to the Company. The Transfer Notice
shall name the proposed transferee and state the number of such Shares the
Participant proposes to transfer (the "Offered Shares"), the price per share and
all other material terms and conditions of the transfer.

     (b) COMPANY RIGHT TO PURCHASE. For 30 days following its receipt of such
Transfer Notice, the Company shall have the option to purchase all or part of
the Offered Shares at the price and upon the terms set forth in the Transfer
Notice. In the event the Company elects to purchase all or part of the Offered
Shares, it shall give written notice of such election to the Participant within
such 30-day period. Within 10 days after his receipt of such notice, the
Participant shall tender to the Company at its principal offices the certificate
or certificates

                                       2
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representing the Offered Shares to be purchased by the Company, duly endorsed in
blank by the Participant or with duly endorsed stock powers attached thereto,
all in a form suitable for transfer of the Offered Shares to the Company.
Promptly following receipt of such certificate or certificates, the Company
shall deliver or mail to the Participant a check in payment of the purchase
price for such Offered Shares; PROVIDED THAT if the terms of payment set forth
in the Transfer Notice were other than cash against delivery, the Company may
pay for the Offered Shares on the same terms and conditions as were set forth in
the Transfer Notice; and PROVIDED FURTHER that any delay in making such payment
shall not invalidate the Company's exercise of its option to purchase the
Offered Shares.

     (c) SHARES NOT PURCHASED BY COMPANY. If the Company does not elect to
acquire all of the Offered Shares, the Participant may, within the 30-day period
following the expiration of the option granted to the Company under subsection
(b) above, transfer the Offered Shares which the Company has not elected to
acquire to the proposed transferee, PROVIDED THAT such transfer shall not be on
terms and conditions more favorable to the transferee than those contained in
the Transfer Notice. Notwithstanding any of the above, all Offered Shares
transferred pursuant to this Section 4 shall remain subject to the right of
first refusal set forth in this Section 4 and such transferee shall, as a
condition to such transfer, deliver to the Company a written instrument
confirming that such transferee shall be bound by all of the terms and
conditions of this Section 4.

     (d) CONSEQUENCES OF NON-DELIVERY. After the time at which the Offered
Shares are required to be delivered to the Company for transfer to the Company
pursuant to subsection (b) above, the Company shall not pay any dividend to the
Participant on account of such Offered Shares or permit the Participant to
exercise any of the privileges or rights of a stockholder with respect to such
Offered Shares, but shall, in so far as permitted by law, treat the Company as
the owner of such Offered Shares.

     (e) EXEMPT TRANSACTIONS. The following transactions shall be exempt from
the provisions of this Section 4:

          (1) any transfer of Shares to or for the benefit of any spouse, child
     or grandchild of the Participant, or to a trust for their benefit;

          (2) any transfer pursuant to an effective registration statement
     filed by the Company under the Securities Act of 1933, as amended (the
     "Securities Act"); and

          (3) the sale of all or substantially all of the shares of capital
     stock of the Company (including pursuant to a merger or consolidation);

PROVIDED, HOWEVER, that in the case of a transfer pursuant to clause (1) above,
such Shares shall remain subject to the right of first refusal set forth in this
Section 4 and such transferee shall, as a condition to such transfer, deliver to
the Company a written instrument confirming that such transferee shall be bound
by all of the terms and conditions of this Section 4.

     (f) ASSIGNMENT OF COMPANY RIGHT. The Company may assign its rights to
purchase Offered Shares in any particular transaction under this Section 4 to
one or more persons or entities.

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     (g) TERMINATION. The provisions of this Section 4 shall terminate upon the
earlier of the following events:

          (1) the closing of the sale of shares of Common Stock in an
     underwritten public offering pursuant to an effective registration
     statement filed by the Company under the Securities Act; or

          (2) the sale of all or substantially all of the capital stock, assets
     or business of the Company, by merger, consolidation, sale of assets or
     otherwise (other than a merger or consolidation in which all or
     substantially all of the individuals and entities who were beneficial
     owners of the Common Stock immediately prior to such transaction
     beneficially own, directly or indirectly, more than 75% of the outstanding
     securities entitled to vote generally in the election of directors of the
     resulting, surviving or acquiring corporation in such transaction).

     (h) NO OBLIGATION TO RECOGNIZE INVALID TRANSFER. The Company shall not be
required (1) to transfer on its books any of the Shares which shall have been
sold or transferred in violation of any of the provisions set forth in this
Section 4, or (2) to treat as owner of such Shares or to pay dividends to any
transferee to whom any such Shares shall have been so sold or transferred.

     (i) LEGENDS. The certificate representing Shares shall bear a legend
substantially in the following form (in addition to, or in combination with, any
legend required by applicable federal and state securities laws and agreements
relating to the transfer of the Company securities):

         "The shares represented by this certificate are subject to a right of
         first refusal in favor of the Company, as provided in a certain stock
         option agreement with the Company."

5.   AGREEMENT IN CONNECTION WITH PUBLIC OFFERING.

     The Participant agrees, in connection with the initial underwritten public
offering of the Company's securities pursuant to a registration statement under
the Securities Act, (i) not to sell, make short sale of, loan, grant any options
for the purchase of, or otherwise dispose of any shares of Common Stock held by
the Participant (other than those shares included in the offering) without the
prior written consent of the Company or the underwriters managing such initial
underwritten public offering of the Company's securities for a period of 180
days from the effective date of such registration statement, and (ii) to execute
any agreement reflecting clause (i) above as may be requested by the Company or
the managing underwriters at the time of such offering.

6.   TAX MATTERS.

     (a) WITHHOLDING. No Shares will be issued pursuant to the exercise of this
option unless and until the Participant pays to the Company, or makes provision
satisfactory to the Company for payment of, any federal, state or local
withholding taxes required by law to be withheld in respect of this option.

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     (b) DISQUALIFYING DISPOSITION. If the Participant disposes of Shares
acquired upon exercise of this option within two years from the Grant Date or
one year after such Shares were acquired pursuant to exercise of this option,
the Participant shall notify the Company in writing of such disposition.

7.   NONTRANSFERABILITY OF OPTION.

     This option may not be sold, assigned, transferred, pledged or otherwise
encumbered by the Participant, either voluntarily or by operation of law, except
by will or the laws of descent and distribution, and, during the lifetime of the
Participant, this option shall be exercisable only by the Participant.

8.   PROVISIONS OF THE PLAN.

     This option is subject to the provisions of the Plan, a copy of which is
furnished to the Participant with this option.

     IN WITNESS WHEREOF, the Company has caused this option to be executed under
its corporate seal by its duly authorized officer. This option shall take effect
as a sealed instrument.

                                  NITROMED, INC.

Dated:                            By:
        ----------                     ----------------------------------------
                                       Name:
                                              ---------------------------------
                                       Title:
                                              ---------------------------------

                                       5
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                            PARTICIPANT'S ACCEPTANCE

         The undersigned  hereby accepts the foregoing  option and agrees to the
terms and conditions thereof.  The undersigned hereby acknowledges  receipt of a
copy of the Company's Amended and Restated 2003 Stock Incentive Plan.

                                        PARTICIPANT:

                                        --------------------------

                                        Address:
                                                  ----------------

                                                  ----------------

                                       6<PAGE>

                                                                  Exhibit 10.29

                                 NITROMED, INC.

                       Nonstatutory Stock Option Agreement
        Granted Under the Amended and Restated 2003 Stock Incentive Plan

1.   GRANT OF OPTION.

     This agreement evidences the grant by NitroMed, Inc., a Delaware
corporation (the "Company"), on , 200[ ] (the "Grant Date") to [ ], an
[employee], [consultant], [director] of the Company (the "Participant"), of an
option to purchase, in whole or in part, on the terms provided herein and in the
Company's Amended and Restated 2003 Stock Incentive Plan (the "Plan"), a total
of [ ] shares (the "Shares") of common stock, $.01 par value per share, of the
Company ("Common Stock") at $[ ] per Share. Unless earlier terminated, this
option shall expire at 5:00 p.m., Eastern time, on [_______] (the "Final
Exercise Date").

     It is intended that the option evidenced by this agreement shall not be an
incentive stock option as defined in Section 422 of the Internal Revenue Code of
1986, as amended, and any regulations promulgated thereunder (the "Code").
Except as otherwise indicated by the context, the term "Participant", as used in
this option, shall be deemed to include any person who acquires the right to
exercise this option validly under its terms.

2.   VESTING SCHEDULE.

     This option will become exercisable ("vest") as to    % of the original
number of Shares on the [first] anniversary of the Grant Date and as to an
additional    % of the original number of Shares at the end of each
successive [three-month]period following the first anniversary of the Grant
Date until the [fourth]anniversary of the Grant Date.

     The right of exercise shall be cumulative so that to the extent the option
is not exercised in any period to the maximum extent permissible it shall
continue to be exercisable, in whole or in part, with respect to all Shares for
which it is vested until the earlier of the Final Exercise Date or the
termination of this option under Section 3 hereof or the Plan.

3.   EXERCISE OF OPTION.

     (a) FORM OF EXERCISE. Each election to exercise this option shall be in
writing, signed by the Participant, and received by the Company at its principal
office, accompanied by this agreement, and payment in full in the manner
provided in the Plan. The Participant may purchase less than the number of
shares covered hereby, provided that no partial exercise of this option may be
for any fractional share.

     (b) CONTINUOUS RELATIONSHIP WITH THE COMPANY REQUIRED. Except as otherwise
provided in this Section 3, this option may not be exercised unless the
Participant, at the time he or she exercises this option, is, and has been at
all times since the Grant Date, an employee or officer of, or consultant or
advisor to, the Company or any other entity the employees, officers,

<PAGE>

directors, consultants, or advisors of which are eligible to receive option
grants under the Plan (an "Eligible Participant").

     (c) TERMINATION OF RELATIONSHIP WITH THE COMPANY. If the Participant ceases
to be an Eligible Participant for any reason, then, except as provided in
paragraphs (d) and (e) below, the right to exercise this option shall terminate
three months after such cessation (but in no event after the Final Exercise
Date), PROVIDED THAT this option shall be exercisable only to the extent that
the Participant was entitled to exercise this option on the date of such
cessation. Notwithstanding the foregoing, if the Participant, prior to the Final
Exercise Date, violates the non-competition or confidentiality provisions of any
employment contract, confidentiality and nondisclosure agreement or other
agreement between the Participant and the Company, the right to exercise this
option shall terminate immediately upon such violation.

     (d) EXERCISE PERIOD UPON DEATH OR DISABILITY. If the Participant dies or
becomes disabled (within the meaning of Section 22(e)(3) of the Code) prior to
the Final Exercise Date while he or she is an Eligible Participant and the
Company has not terminated such relationship for "cause" as specified in
paragraph (e) below, this option shall be exercisable, within the period of one
year following the date of death or disability of the Participant, by the
Participant (or in the case of death by an authorized transferee), PROVIDED THAT
this option shall be exercisable only to the extent that this option was
exercisable by the Participant on the date of his or her death or disability,
and further provided that this option shall not be exercisable after the Final
Exercise Date.

     (e) DISCHARGE FOR CAUSE. If the Participant, prior to the Final Exercise
Date, is discharged by the Company for "cause" (as defined below), the right to
exercise this option shall terminate immediately upon the effective date of such
discharge. "Cause" shall mean willful misconduct by the Participant or willful
failure by the Participant to perform his or her responsibilities to the Company
(including, without limitation, breach by the Participant of any provision of
any employment, consulting, advisory, nondisclosure, non-competition or other
similar agreement between the Participant and the Company), as determined by the
Company, which determination shall be conclusive. The Participant shall be
considered to have been discharged for "Cause" if the Company determines, within
30 days after the Participant's resignation, that discharge for cause was
warranted.

4.   COMPANY RIGHT OF FIRST REFUSAL.

     (a) NOTICE OF PROPOSED TRANSFER. If the Participant proposes to sell,
assign, transfer, pledge, hypothecate or otherwise dispose of, by operation of
law or otherwise (collectively, "transfer") any Shares acquired upon exercise of
this option, then the Participant shall first give written notice of the
proposed transfer (the "Transfer Notice") to the Company. The Transfer Notice
shall name the proposed transferee and state the number of such Shares the
Participant proposes to transfer (the "Offered Shares"), the price per share and
all other material terms and conditions of the transfer.

     (b) COMPANY RIGHT TO PURCHASE. For 30 days following its receipt of such
Transfer Notice, the Company shall have the option to purchase all or part of
the Offered Shares at the price and upon the terms set forth in the Transfer
Notice. In the event the Company elects to

                                       2
<PAGE>

purchase all or part of the Offered Shares, it shall give written notice of such
election to the Participant within such 30-day period. Within 10 days after his
receipt of such notice, the Participant shall tender to the Company at its
principal offices the certificate or certificates representing the Offered
Shares to be purchased by the Company, duly endorsed in blank by the Participant
or with duly endorsed stock powers attached thereto, all in a form suitable for
transfer of the Offered Shares to the Company. Promptly following receipt of
such certificate or certificates, the Company shall deliver or mail to the
Participant a check in payment of the purchase price for such Offered Shares;
PROVIDED THAT if the terms of payment set forth in the Transfer Notice were
other than cash against delivery, the Company may pay for the Offered Shares on
the same terms and conditions as were set forth in the Transfer Notice; and
PROVIDED FURTHER that any delay in making such payment shall not invalidate the
Company's exercise of its option to purchase the Offered Shares.

     (c) SHARES NOT PURCHASED BY COMPANY. If the Company does not elect to
acquire all of the Offered Shares, the Participant may, within the 30-day period
following the expiration of the option granted to the Company under subsection
(b) above, transfer the Offered Shares which the Company has not elected to
acquire to the proposed transferee, PROVIDED THAT such transfer shall not be on
terms and conditions more favorable to the transferee than those contained in
the Transfer Notice. Notwithstanding any of the above, all Offered Shares
transferred pursuant to this Section 4 shall remain subject to the right of
first refusal set forth in this Section 4 and such transferee shall, as a
condition to such transfer, deliver to the Company a written instrument
confirming that such transferee shall be bound by all of the terms and
conditions of this Section 4.

     (d) CONSEQUENCES OF NON-DELIVERY. After the time at which the Offered
Shares are required to be delivered to the Company for transfer to the Company
pursuant to subsection (b) above, the Company shall not pay any dividend to the
Participant on account of such Offered Shares or permit the Participant to
exercise any of the privileges or rights of a stockholder with respect to such
Offered Shares, but shall, in so far as permitted by law, treat the Company as
the owner of such Offered Shares.

     (e) EXEMPT TRANSACTIONS. The following transactions shall be exempt from
the provisions of this Section 4:

         (1) any transfer of Shares to or for the benefit of any spouse, child
     or grandchild of the Participant, or to a trust for their benefit;

         (2) any transfer pursuant to an effective registration statement filed
     by the Company under the Securities Act of 1933, as amended (the
     "Securities Act"); and

         (3) the sale of all or substantially all of the shares of capital stock
     of the Company (including pursuant to a merger or consolidation);

PROVIDED, HOWEVER, that in the case of a transfer pursuant to clause (1) above,
such Shares shall remain subject to the right of first refusal set forth in this
Section 4 and such transferee shall, as a condition to such transfer, deliver to
the Company a written instrument confirming that such transferee shall be bound
by all of the terms and conditions of this Section 4.

                                       3
<PAGE>

     (f) ASSIGNMENT OF COMPANY RIGHT. The Company may assign its rights to
purchase Offered Shares in any particular transaction under this Section 4 to
one or more persons or entities.

     (g) TERMINATION. The provisions of this Section 4 shall terminate upon the
earlier of the following events:

         (1) the closing of the sale of shares of Common Stock in an
     underwritten public offering pursuant to an effective registration
     statement filed by the Company under the Securities Act; or

         (2) the sale of all or substantially all of the capital stock, assets
     or business of the Company, by merger, consolidation, sale of assets or
     otherwise (other than a merger or consolidation in which all or
     substantially all of the individuals and entities who were beneficial
     owners of the Common Stock immediately prior to such transaction
     beneficially own, directly or indirectly, more than 75% of the outstanding
     securities entitled to vote generally in the election of directors of the
     resulting, surviving or acquiring corporation in such transaction).

     (h) NO OBLIGATION TO RECOGNIZE INVALID TRANSFER. The Company shall not be
required (1) to transfer on its books any of the Shares which shall have been
sold or transferred in violation of any of the provisions set forth in this
Section 4, or (2) to treat as owner of such Shares or to pay dividends to any
transferee to whom any such Shares shall have been so sold or transferred.

     (i) LEGENDS. The certificate representing Shares shall bear a legend
substantially in the following form (in addition to, or in combination with, any
legend required by applicable federal and state securities laws and agreements
relating to the transfer of the Company securities):

         "The shares represented by this certificate are subject to a
         right of first refusal in favor of the Company, as provided in
         a certain stock option agreement with the Company."

5.   AGREEMENT IN CONNECTION WITH PUBLIC OFFERING.

     The Participant agrees, in connection with the initial underwritten public
offering of the Company's securities pursuant to a registration statement under
the Securities Act, (i) not to sell, make short sale of, loan, grant any options
for the purchase of, or otherwise dispose of any shares of Common Stock held by
the Participant (other than those shares included in the offering) without the
prior written consent of the Company or the underwriters managing such initial
underwritten public offering of the Company's securities for a period of 180
days from the effective date of such registration statement, and (ii) to execute
any agreement reflecting clause (i) above as may be requested by the Company or
the managing underwriters at the time of such offering.

6.   WITHHOLDING.

                                       4
<PAGE>

     No Shares will be issued pursuant to the exercise of this option unless and
until the Participant pays to the Company, or makes provision satisfactory to
the Company for payment of, any federal, state or local withholding taxes
required by law to be withheld in respect of this option.

7.   NONTRANSFERABILITY OF OPTION.

     This option may not be sold, assigned, transferred, pledged or otherwise
encumbered by the Participant, either voluntarily or by operation of law, except
by will or the laws of descent and distribution, and, during the lifetime of the
Participant, this option shall be exercisable only by the Participant.

8.   PROVISIONS OF THE PLAN.

     This option is subject to the provisions of the Plan, a copy of which is
furnished to the Participant with this option.

     IN WITNESS WHEREOF, the Company has caused this option to be executed under
its corporate seal by its duly authorized officer. This option shall take effect
as a sealed instrument.

                                     NITROMED, INC.

Dated:                               By:
       ---------                          -------------------------------------

                                          Name:
                                                 ------------------------------

                                          Title:
                                                 ------------------------------

                                       5
<PAGE>

                            PARTICIPANT'S ACCEPTANCE

         The undersigned hereby accepts the foregoing  option and agrees to the
terms and conditions thereof.  The undersigned hereby acknowledges receipt of a
copy of the Company's Amended and Restated 2003 Stock Incentive Plan.

                                     PARTICIPANT:

                                     ----------------------------

                                      Address:
                                                -----------------

                                                -----------------

                                       6

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