Document:

Exhibit
4.5

HOSPIRA, INC.

OFFICERS’ CERTIFICATE

and

COMPANY ORDER

March 23, 2007

With respect to the issuance by Hospira, Inc. (the “Company”)
of $375,000,000 aggregate
principal amount of Floating Rate Notes due 2010 (the “2010 Notes”),
$500,000,000 aggregate principal amount of 5.55% Notes due 2012 (the “2012
Notes”) and $550,000,000 aggregate principal amount of 6.05% Notes due 2017
(the “2017 Notes” and, together with the 2010 Notes and the 2012 Notes, the “Notes”),
Thomas E. Werner and Brian J. Smith, officers of the Company, certify pursuant
to Sections 3.1 and 3.3 of the Indenture, dated as of June 14, 2004 (the “Indenture”),
between the Company and LaSalle Bank National Association, as Trustee (the “Trustee”),
as follows:

1.                                       We
have read Sections 2.1, 3.1 and 3.3 of the Indenture and the definitions
therein relating hereto, reviewed the resolutions of the Board of Directors of
the Company adopted on September 20, 2006 (attached as Exhibit B to the
Secretary’s Certificate of even date herewith), the Actions of the Authorized
Officers of March 20, 2007 (attached as Exhibit C to the Secretary’s
Certificate of even date herewith), conferred with executive officers of the
Company and, in our opinion, made such other examinations and investigations as
are necessary to enable us to express an informed opinion as to whether
Sections 2.1, 3.1 and 3.3 of the Indenture have been complied with.

2.                                       Based
on the above-described examinations and investigations, in our opinion, all
conditions precedent relating to the authentication and delivery of the Notes,
including those conditions under Sections 2.1, 3.1 and 3.3 of the Indenture,
have been complied with.

3.                                       The
terms of the Notes are set forth in the Actions of the Authorized Officers,
dated March 20, 2007 (attached as Exhibit C to the Secretary’s Certificate of
even date herewith).

4.                                       In
accordance with the provisions of Section 3.3 of the Indenture, the Trustee is
hereby authorized and requested to authenticate the Notes and to deliver such
Notes to or at the direction of Morgan
Stanley & Co. Incorporated, ABN AMRO Incorporated and Citigroup Global
Markets Inc., as managers of the several underwriters.

Capitalized
terms used herein and not otherwise defined herein shall have the respective
meanings assigned thereto in the Indenture.

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IN
WITNESS WHEREOF, the undersigned have executed this Officers’ Certificate and
Company Order as of the date first above written.

	
  

  	
  HOSPIRA,
  INC.

  
	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  By: 

  	
  /s/ Thomas E. Werner

  	
   

  
	
   

  	
  Name:

  	
  Thomas E. Werner

  
	
   

  	
  Title:

  	
  Senior Vice President, Finance and 

  Chief Financial Officer

  
						

 

	
  

  	
  By: 

  	
  /s/ Brian J. Smith

  	
   

  
	
   

  	
  Name:

  	
  Brian J. Smith

  
	
   

  	
  Title:

  	
  Senior Vice President, General Counsel

  and Secretary

  
					

 

 2Exhibit
10.1

Summary
of 2007 Terms of Employment for Named Executive Officers

Salary

	
  Officer

  	
   

  	
  Salary

  	
   

  
	
  Christopher B. Begley,
  Chief Executive Officer

  	
   

  	
  $

  	
  960,000

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  Terrence C. Kearney,
  Chief Operating Officer

  	
   

  	
  575,000

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  Edward A. Ogunro,
  Senior Vice President, Research and Development and Medical Affairs, and
  Chief Scientific Officer

  	
   

  	
  425,000

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  Thomas E. Werner,
  Senior Vice President, Finance and Chief Financial Officer

  	
   

  	
  405,000

  	
   

  
	
   

  	
   

  	
   

  	
   

  
	
  Brian J. Smith, Senior Vice President, General Counsel and Secretary

  	
   

  	
  390,000

  	
   

  
					

 

The salary for each
officer took effect on March 26, 2007.

Annual Cash Incentive

Each is a participant in
the Hospira Inc. 2004 Performance Incentive Plan.  The plan provides for a base award equal to
2.0% of Hospira’s earnings before interest, taxes, depreciation and
amortization for the chief executive officer, 1.5% for the chief operating
officer and 1.0% for the other named executive officers.  The compensation committee of Hospira’s board
of directors has discretion to reduce, but not increase, the award from the
base award.  The committee will consider
Hospira’s adjusted net income, net sales, cash flows and corporate well-being
as factors in exercising such discretion and determining actual awards payable
under such plan for 2007 performance.

Equity

Each officer is eligible
to receive awards under the Hospira 2004 Long-Term Stock Incentive Plan, which
is filed as Exhibit 10.8 to Hospira’s Annual Report on Form 10-K for the year
ended December 31, 2006 (the “2006 Form 10-K”). 
 Awards are made in the discretion
of the compensation committee of Hospira’s board of directors.

Change in Control

Each officer is party to
a change-in-control agreement in the forms filed as Exhibit 10.12(a) (for each
officer other than Mr. Werner) and Exhibit 10.12(b) to the 2006 Form

10-K.  A description of these agreements was
included in Hospira’s proxy statement for the 2007 Annual Meeting of
Shareholders.Exhibit 10.1

ADVANCE WORK AGREEMENT

THIS ADVANCE WORK AGREEMENT
(this “Agreement”) is made as of this 12th day of March,
2007, by and between Aventine Renewable Energy Holdings, Inc. (“Client”) and
Delta-T Corporation (“Delta-T”) (Client and Delta-T are referred to herein as
the “Parties”)

RECITALS:

WHEREAS, Client wishes to expedite the purchasing of
plant equipment in advance of completing the negotiation of an engineering,
procurement and construction (“EPC”) contract(s) with Kiewit Energy Company (“Kiewit”);

WHEREAS, Client desires to enter into an EPC
Contract(s) with Kiewit whereby it is contemplated that Delta-T will provide,
certain engineering, procurement and technology services for up to three (3)
ethanol plants, one (1) with a design capacity of 108 million gallons per year
and two (2) with a design capacity of 108 million gallons per year with the
capability of being expanded to a design capacity of 216 million gallons per
year, of undenatured anhydrous ethanol (the “Plants”).

WHEREAS, Client and Kiewit are presently negotiating
terms of the EPC Contract(s), and the Parties wish to arrange for the immediate
purchase of certain equipment, as identified herein at Exhibit “A”, by Delta-T
on Client’s behalf, prior to the conclusion of the negotiations of the EPC
Contract(s).

WHEREAS, Client authorizes Delta-T to begin, and
Delta-T agrees to perform, the work described in the attached Exhibit “A” (the “Work”).  Delta-T shall perform the Work and Client
shall remit payment to Delta-T for the Work in the manner described in this
Agreement.

WHEREAS, the purpose of this Agreement is to (i) cause
Delta-T to perform the Work in accordance with Exhibit “A” and this Agreement,
and (ii) set forth the conditions pursuant to which Delta-T shall perform the
Work and receive payments for such performance.

NOW THEREFORE, in consideration of the premises set
forth above and the promises contained in this Agreement, the Parties
acknowledge good and valuable consideration, and agree as follows:

Article 1 — Undertakings; Relationship Among The
Parties  The Parties
hereby agree to work together under this Agreement for the purposes of ordering
long-lead equipment that will be necessary for construction of the Plants, for
which it is contemplated Delta-T Technology would be used, prior to Client’s
finalizing negotiations and entering into the EPC Contract(s).  The equipment for the Plants to be purchased
under this Advanced Work Agreement,  the
progress payments, and the payment dates for 
such equipment, which have been agreed by the Parties as of the date
hereof, are identified in Exhibit “A”. 
From time to time, as the Parties agree upon additional equipment to be
ordered by Delta-T pursuant to the terms of this Agreement, additional Exhibit “A’s”
may be added hereto for such equipment, and said items shall also be deemed to
constitute “Work” as such term is defined in this Agreement.

 1
 

Article 2 — Each Party’s Responsibilities  Each Party shall be responsible for the
following areas in furtherance of the Work:

Client shall forward the amounts specified in Exhibit “A”
on the dates and in the amounts as specified in said Exhibit “A” covering the
items of equipment referenced in such Exhibit “A” via electronic wire transfer
to Delta-T in Williamsburg, Virginia SOLELY for Work to be performed under this
Agreement.  Upon receipt of the first
payment set forth on Exhibit “A”, Delta-T shall promptly begin the Work and
proceed to acquire the equipment which is the subject of such authorization in
accordance with the Exhibit “A’s” attached to (or hereafter added to) this
Agreement.  Delta-T shall promptly pay
all amounts received from Client by Delta-T to the appropriate vendors or
manufacturers of said equipment (less the portions of such amounts representing
the portion of Delta-T’s procurement fee included in such amounts).  Delta-T shall also promptly provide Client
with written documentation from the vendors and manufacturers of the equipment
showing payment of said invoices by Delta-T (redacting any cost data).  The parties acknowledge that the purpose of
this Agreement is to perform the Work only, and not to address all of the
potential services to be addressed in the EPC Contract(s) for the Plants.  Accordingly, by agreeing to perform the Work
described herein, Delta-T does not guarantee the completion of all of the
prospective services to be addressed in such EPC Contract(s).

It is agreed and acknowledged that Delta-T shall not
be required to perform any Work outside the scope of this Agreement unless the
Parties enter into a subsequent written agreement covering such additional
work.

Notwithstanding anything to the contrary contained
herein, it is agreed and understood that all payments made by Client to Delta-T
under this Agreement shall be credited dollar for dollar towards the Contract
Price under the EPC Contract(s) for the applicable Plants for which the
equipment which is the subject of the Work pertains.

Article 3 — Assignment

3.1           Delta-T
hereby agrees that, upon its receipt of payment for the cost of any equipment
(as more specifically described in Exhibit “A”) and delivery of such equipment
to the Plant site designated by Client, or such other location designated by
Client, it shall assign all of its rights, title and interest in and to the
equipment to Client.  Further, Delta-T
shall include language acceptable to Client in its agreements and purchase
orders with any vendors or manufacturers of equipment requiring each such
manufacturer or vendor to execute reasonable and appropriate documentation
evidencing the assignment of ownership, the assignment of all warranties
delivered in connection with said equipment, and the assignment of all other
rights, title and interest in and to the equipment to Client upon written
demand.  Delta-T shall identify and
assign to Client all warranties received in connection with the Work.  If any such warranties are not assignable,
then to the extent Delta-T receives any warranties from the equipment vendor or
manufacturer, Delta-T shall warrant the same to Client.  In addition, upon Delta-T’s receipt of each
payment applicable to any equipment set forth on Exhibit “A”, Delta-T hereby
grants to Client a first priority security interest in all of Delta-T’s rights
or interests in such equipment up to the amount of such payment and agrees to
execute such documents as Client may request in order to more fully perfect
such security interest. In the event Delta-T fails to complete purchase of said
equipment, Client shall have the right to assume any and all contracts and/or
purchase

 2
 

orders for purchase of said equipment, as well as to
pursue any other remedies against Delta-T for breach of contract.  Except as provided herein, neither Client nor
Delta-T may assign or delegate this Agreement or any of its rights or
obligations under this Agreement to any third party without the written consent
of the other party.

Article 4 — Confidentiality

4.1           Each
Party agrees that all data, processes, equipment, technology, know-how, design,
specifications, financial information, or other information disclosed to it by
the other Party under this Agreement shall be maintained as confidential.

4.2           All
obligations to adhere to the previously executed Confidentiality Agreement(s)
between the Parties shall remain in full force and effect during the term of
this Agreement (as to the information which is the subject of Article 4.1
above), or beyond if provided in such Confidentiality Agreement(s).

Article 5 — Rights In Data

5.1           Nothing
in this Agreement shall be interpreted as granting a license to use or
transferring any intellectual property rights of any Party, including but not
limited to, copyrights, trademarks, trade secrets and patents, unless
specifically stated in a separate writing signed by the Parties.

Article 6 — Term of Agreement

6.1                                 This
Agreement shall terminate upon the earliest occurrence of any of the events
listed below:

(a)                                  the
Parties mutually agree in writing to terminate this Agreement; or

(b)                                 if
either Party breaches this Agreement for any reason other than non-payment
which is covered under Article 6.1(c), the non-breaching party may terminate
this Agreement in the event that the breaching party has not cured such breach
within ten (10) business days of receipt of written notice of such breach from
the non-breaching party; or

(c)                                if
Client fails to make full payment to Delta-T of any amount owed by the due date
specified in Exhibit A, Delta-T may terminate this Agreement if Client has not
made such payment within five (5) days of Client’s receipt of written notice
from Delta-T of such failure to make such payment; or

(d)                                 completion
of the Work under this Agreement; or

(e)                                  upon
prior written notice by Client to Delta-T; or

(f)                                    if
an EPC Contract or EPC Contracts are not executed within one hundred eighty
(180) days from the date of this Agreement for one or more Plants applicable to
all of the Work which is the subject of this Agreement, and Client elects to
terminate this Agreement by written notice to Delta-T.

 3
 

In the event of termination in accordance with any
subsection (a), (b) or (f) of this Article 6, any payments made to Delta-T by
Client and not expended in furtherance of the Work (after subtracting Delta-T’s
profit, overhead and contingencies) shall be refunded to Client within ten (10)
business days of said termination.  In
addition, in the event of termination in accordance with Article 6.1(a),  6.1(b) or 6.1(f), Client shall have the
option to assume all of Delta-T’s rights and obligations for the purchase of
any or all of the equipment included in the Work, and in the event Client
exercises such option, Delta-T shall cooperate with Client in having Delta-T’s
rights and obligations with respect to the equipment for which Client has
exercised such option, transferred to Client.

In the event that an EPC Contract is executed and
delivered, all Work performed hereunder applicable to the Plant which is the
subject of such EPC Contract (with Client to designate to Delta-T the
applicable EPC Contract to which the Work, or portion of the Work, as
applicable, pertains) and all payments made hereunder with respect to such Work
shall be treated as Work performed and payments made under such EPC
Contract.  In addition, the Parties
acknowledge that all of the terms and conditions set forth in this Agreement
applicable to the Work performed, or to be performed, hereunder applicable to
the Plant which is the subject of such EPC Contract shall be superseded and
replaced in their entirety by the terms and conditions of such EPC Contract
following the issuance by Client of the Notice to Proceed under such EPC Contract,
including without limitation, the provisions of Articles 10. and 11.  As set forth in Article 2,
however, all payments under this Agreement applicable to Work for one of the
Plants shall be credited dollar for dollar towards the Contract Price under the
EPC Contract applicable to such Plant.

Article 7 — Integration

7.1           Except
as otherwise provided, this Agreement, together with all Exhibits attached
hereto, represents the entire and integrated agreement between the Parties with
respect to the subject matter referenced herein.  It supersedes all prior agreements with
respect to the Work except the Non-Disclosure Agreements referenced above.

Article 8 — Governing Law

8.1           This
Agreement shall be governed by and construed in accordance with the laws of the
State of Virginia.

Article 9 — Consequential Damages

9.1           In
no event shall either Party, or their related companies be liable to each other
for loss of profits or revenue; loss of use; loss of opportunity; loss of
goodwill; cost of substitute facilities, goods or services; cost of capital; or
for any special, consequential, incidental, or indirect, punitive, or exemplary
damages resulting in any way from the performance of this Agreement, unless
such damages are caused by a violation of the confidentiality provisions of
this Agreement.  For the avoidance of
doubt, the foregoing shall not be construed to mean that Delta-T is not
obligated to deliver the equipment it has agreed to provide to Client pursuant
to the terms hereof.

 4
 

Article 10 — 
Limitation of Liability

10.1  In no case
shall Delta-T have any liability under this Agreement in excess of insured
claims and amounts paid by Client hereunder.

Article 11 — Indemnification

11.1         Delta-T,
to the fullest extent permitted by law, shall indemnify, defend and hold
harmless Client, and its officers, directors, employees and agents from and
against all claims, losses, damages, liabilities, including attorneys’ fees and
expenses, for bodily injury, sickness or death, and property damage or
destruction to the extent resulting from the acts, errors or omissions of any
of Delta-T’s officers, agents, employees, Delta-T’s subcontractors or any other
person for whose acts any of them may be liable, or for breach of this
Agreement by Delta-T.

11.2         Client,
to the fullest extent permitted by law, shall indemnify, defend and hold
harmless each of Delta-T, officers, directors, employees and agents from and
against claims, losses, damages, liabilities, including attorneys’ fees and
expenses, for bodily injury, sickness or death, and property damage or
destruction  to the extent resulting from
the acts, errors or omissions of Client, its officers, directors, employees,
agents, and Client’s separate contractors or anyone for whose acts any of them
may be liable, or for breach of this Agreement by Client.

Article 12 — Progress Updates

12.1         Delta-T
shall provide Client with monthly, written updates during the term of this
Agreement setting forth quantity and vendor information for equipment for which
orders  have been placed.  Delta-T shall also provide Client with
updates on any cancellation fees associated with purchased equipment.

Article 13 — Counterparts

13.1         This
Agreement may be executed in any number of counterparts and by different
parties hereto in separate counterparts, each of which when so executed and
delivered shall be deemed an original, but all such counterparts together shall
constitute but one and the same instrument.

13.2         This
Agreement shall not be construed as creating a formal business entity of any
kind, or as creating a joint venture, partnership, agency, fiduciary or
employment relationship among the Parties. 
No Party shall have the authority or right, and no Party shall hold
itself out as having the authority or right, to assume, create or undertake any
obligation of any kind whatsoever, express or implied, on behalf of or in the
name of another Party without the express written consent of such other Party.

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IN WITNESS WHEREOF,
the Parties hereto have executed this Agreement, effective as of the date first
written above.

AVENTINE RENEWABLE ENERGY
HOLDINGS, INC.

	
  By:

  	
  /s/ Jeffrey A. Moery

  	
   

  
	
  Title:

  	
  VP Plant Construction

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  DELTA-T CORPORATION

  	
   

  
	
   

  	
   

  	
   

  
	
  By:

  	
  /s/ James T. Callahan

  	
   

  
	
  Title:

  	
  Chief Operating Officer

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  KIEWIT ENERGY COMPANY(1)

  	
   

  
	
   

  	
   

  	
   

  
	
  By:

  	
  /s/ Bradley J. Kaufman

  	
   

  
	
  Title:

  	
  President

  	
   

  
				

(1)             This
Agreement is executed by Kiewit Energy Company (“Kiewit”) solely for the
purposes of evidencing its agreement that, if an EPC Contract is duly
negotiated and entered into between Kiewit and Client with respect to a Plant
for which all or any portion of the Work hereunder pertains, Kiewit agrees that
the payments made under this Agreement shall be credited to any applicable EPC
Contract price and the provisions of the EPC Contract shall govern such Work,
to the extent a design and procurement subcontract between Kiewit and Delta-T
for such Plant  is duly negotiated and
entered into, and further provided that such credit and the provisions of the
EPC Contract shall apply only to the extent of the Work applicable to the scope
of such EPC Contract, as agreed by Client, Kiewit and Delta-T.  Kiewit’s obligations under this Agreement are
strictly limited to this acknowledgement, and Kiewit shall have no obligation
to enter into an EPC Contract or any other agreement with Client or Delta-T,
except to the extent it may do so in its own, sole discretion.

 6

Exhibit A

The confidential
information has been omitted and filed separately with the Securities and
Exchange Commission.

 1

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