Document:

Supplemental Indenture, dated as of March 28, 2012

 Exhibit 4.1 
 SUPPLEMENTAL INDENTURE 
 This SUPPLEMENTAL INDENTURE, dated as of
March 28, 2012 (the “Supplemental Indenture”), is by and between United Surgical Partners International, Inc., a Delaware corporation (the “Company”), and U.S. Bank National Association, as trustee under the
Indenture referred to below (the “Trustee”). 
 WITNESSETH 

WHEREAS, the Company and the Trustee have previously become parties to an Indenture, dated as of April 19, 2007 (as amended,
supplemented or otherwise modified from time to time, the “Indenture”), providing for the issuance of the Company’s 
 87/8% Senior Subordinated Notes due 2017 (the “Cash Notes”)
and 91/4%/10% Senior Subordinated Toggle Notes due 2017 (the “Toggle
Notes,” and collectively, the “Notes”); 
 WHEREAS, the Company proposes to amend the Indenture and
the Notes as contemplated by this Supplemental Indenture (such amendments, collectively, the “Amendments”); 

WHEREAS, pursuant to Section 9.02 of the Indenture, the Company and the Trustee may amend or supplement the Indenture and the Notes
as contemplated by this Supplemental Indenture with the consent of the Holders of at least a majority in aggregate principal amount of the Notes; 
 WHEREAS, the Company has obtained the consent of the Holders of at least a majority in aggregate principal amount of the outstanding Notes, pursuant to the Offer to Purchase and Consent Solicitation
Statement, dated March 14, 2012 (as amended, supplemented or otherwise modified from time to time, the “Offer to Purchase”), to the Amendments upon the terms and subject to the conditions set forth therein; 

WHEREAS, the Company has duly done and performed all other acts and proceedings required by law, the Indenture and the organizational
documents of the Company to make this Supplemental Indenture a valid and binding agreement of the Company for the purposes herein and has satisfied all other conditions required under Article 9 of the Indenture; and 

WHEREAS, pursuant to Section 9.07, the Trustee is authorized to execute this Supplemental Indenture. 

NOW, THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt of which is hereby
acknowledged, in order to effect the Amendments, the Company agrees with the Trustee as follows: 
 ARTICLE I 

DEFINITIONS AND OTHER PROVISIONS OF GENERAL APPLICATION 
 1.1 Capitalized Terms. Capitalized terms used herein without definition shall have the meanings assigned to them in the Indenture. 

1.2 Effect of Headings. The Article and Section headings herein are for convenience only and shall not affect the construction
hereof. 
 1.3 Successors and Assigns. All covenants and agreements in this Supplemental Indenture by the Company shall
bind its successors and assigns, whether so expressed or not. 
 1.4. Severability Clause. In case any provision in this
Supplemental Indenture shall be held invalid, illegal or unenforceable, the validity, legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

1.5 Trust Indenture Act Controls. If any provision of this Supplemental Indenture limits, qualifies or conflicts with another
provision of this Supplemental Indenture or the Indenture that is required to be included by the Trust Indenture Act of 1939, as amended (the “Act”), as in force at the date this Supplemental Indenture is executed, the provision
required by the Act shall control. 
 1.6 Benefits of Supplemental Indenture. Nothing in this Supplemental Indenture,
express or implied, shall give to any person, other than the parties to this Supplemental Indenture and their successors hereunder and the Holders of the Notes, any benefit of any legal or equitable right, remedy or claim under this Supplemental
Indenture. 
 1.7 Governing Law. This Supplemental Indenture shall be governed by, and construed in accordance with, the
laws of the State of New York. 
 1.8 Reference to and Effect on the Indenture. 

 (a) On and after the Operative Date (as defined in Section 2.1 below),
each reference in the Indenture to “this Indenture,” “hereunder,” “hereof,” or “herein” shall mean and be a reference to the Indenture as supplemented by this Supplemental Indenture, unless the context
otherwise requires. 
 (b) Except as specifically amended by this Supplemental Indenture on the Operative Date,
the Indenture and the Notes are hereby ratified and confirmed and all of the terms, conditions and provisions thereof shall remain in full force and effect. This Supplemental Indenture shall form a part of the Indenture for all purposes, and every
Holder of the Notes heretofore and hereafter authenticated and delivered under the Indenture shall be bound hereby. 
 1.9
Counterparts. The parties hereto may sign one or more copies of this Supplemental Indenture in counterparts, all of which together shall constitute one and the same agreement. The parties agree that facsimile or PDF signatures shall be
accepted as originals for all purposes under this Agreement. 
 ARTICLE II 

AMENDMENTS OF THE INDENTURE AND NOTES 
 2.1 Amendment to Indenture and Notes. Following the execution and delivery by the Company and the Trustee of this Supplemental Indenture, the terms hereof shall become operative on the date (the
“Operative Date”) of acceptance for purchase by the Company of the Notes validly tendered (and not validly withdrawn) pursuant to the Offer to Purchase. Effective as of the Operative Date, the Supplemental Indenture hereby amends
the Indenture and Notes as provided for herein. If the Operative Date does not occur on or prior to the Initial Settlement Date (as defined in the Offer to Purchase), then the terms of this Supplemental Indenture shall be null and void and the
Indenture and Notes shall continue in full force and effect without any modification or amendment hereby. 
 2.2 Deletion of
Certain Provisions. 
 (a) As of the Operative Date, the following sections of the Indenture are hereby
deleted in their entirety and, in the case of each such section, replaced with the phrase “[Intentionally Omitted]”, and any and all references to such sections and any and all obligations thereunder are hereby deleted throughout the
Indenture, and such sections and references shall be of no further force or effect. 
  

			
	 Section Reference
	  	 Description of Provision

	 Section 4.03
	  	Reports
	 Section 4.04
	  	Compliance Certificate
	 Section 4.06
	  	Stay, Extension or Usury Laws
	 Section 4.07
	  	Restricted Payments
	 Section 4.08
	  	Dividend and Other Payment Restrictions Affecting Restricted Subsidiaries
	 Section 4.09
	  	Incurrence of Indebtedness and Issuance of Disqualified Stock and Preferred Stock
	 Section 4.10
	  	Asset Sales
	 Section 4.11
	  	Transactions with Affiliates
	 Section 4.12
	  	Liens
	 Section 4.13
	  	Business Activities
	 Section 4.14
	  	Corporate Existence
	 Section 4.15
	  	Offer to Repurchase Upon Change of Control
	 Section 4.16
	  	No Layering of Debt
	 Section 4.17
	  	Designation of Restricted and Unrestricted Subsidiaries
	 Section 4.18
	  	Payments for Consent
	 Section 4.19
	  	Additional Subsidiary Guarantees
	 Section 4.20
	  	Distributions by Qualified Restricted Subsidiaries

 (b) As of the Operative Date, each of clauses (3) and (4) of
Section 5.01(a), clauses (3), (4), (5), (6) and (7) of Section 6.01 and clauses (2), (3), (4) and (5) of Section 8.04, are hereby deleted in their entirety and, in the case of each such section, replaced with the
phrase “[Intentionally Omitted]” and the Company shall be released from any and all of its obligations thereunder. 

2.3 Amendment of Article 3 of the Indenture. 

(a) Amendment of Section 3.01 (Notices to Trustee). Section 3.01 of the Indenture is hereby amended and
restated in its entirety to read as follows: 

  
 2 

 Section 3.01 Notices to Trustee 

If the Issuer elects to redeem Notes pursuant to the optional redemption provisions of Section 5 of the Notes, the
Issuer shall furnish to the Trustee, at least three days but not more than 60 days before the redemption date, an Officer’s Certificate setting forth: 
  

	 	(1)	the clause of this Indenture pursuant to which the redemption shall occur; 

 

	 	(2)	the redemption date; 

  

	 	(3)	the principal amount of the Cash Pay Notes and/or Toggle Notes, as the case may be, to be redeemed; and 

 

	 	(4)	the redemption price. 

 (b) Amendment of Section 3.02 (Selection of Notes to be Redeemed or Purchased). Section 3.02 of the Indenture is hereby amended and restated in its entirety to read as follows:

 Section 3.02 Selection of Notes To Be Redeemed or Purchased 

If less than all of the Cash Pay Notes and/or Toggle Notes, as the case may be, are to be redeemed or purchased in an
offer to purchase at any time, the Trustee shall select Notes for redemption or purchase on a pro rata basis except: 
  

	 	(1)	if the Notes are listed on any national securities exchange, in compliance with the requirements of the principal national securities exchange on which the Notes are
listed; or 

  

	 	(2)	if otherwise required by law. 

 In the event of partial redemption or purchase by lot, the particular Notes to be redeemed or purchased shall be selected, unless otherwise provided herein, not less than three nor more than 60 days prior
to the redemption or purchase date by the Trustee from the outstanding Notes not previously called for redemption or purchase. 
 The Trustee shall promptly notify the Issuer in writing of the Notes selected for redemption or purchase and, in the case of any Note selected for partial redemption or purchase, the principal amount
thereof to be redeemed or purchased. Notes and portions of Notes selected shall be in amounts of $2,000 or integral multiples of $1,000 in excess thereof; except that if all of the Notes of a Holder are to be redeemed or purchased, the entire
outstanding amount of Notes held by such Holder, even if not a multiple of $1,000, shall be redeemed or purchased. Except as provided in the preceding sentence, provisions of this Indenture that apply to Notes called for redemption or purchase also
apply to portions of Notes called for redemption or purchase. 
 (b) Amendment of Section 3.03 (Notice of
Redemption). Section 3.03 of the Indenture is hereby amended and restated in its entirety to read as follows: 

Section 3.03 Notice of Redemption 
 Subject to the provisions of Section 3.09, at least three days but not more than 60 days before a redemption date, the Issuer shall mail or cause to be mailed, by first class mail, a notice of
redemption to each Holder whose Notes are to be redeemed at its registered address, except that redemption notices may be mailed more than 60 days prior to a redemption date if the notice is issued in connection with a defeasance of the Notes or a
satisfaction and discharge of this Indenture pursuant to Articles 8 or 12 of this Indenture. 
 The notice shall identify the
Notes to be redeemed (including CUSIP Number(s)) and shall state: 
  

	 	(1)	the redemption date; 

  

	 	(2)	the redemption price; 

  

	 	(3)	if any Note is being redeemed in part, the portion of the principal amount of such Note to be redeemed and that, after the redemption date upon surrender of such Note,
a new Note or Notes in principal amount equal to the unredeemed portion shall be issued upon cancellation of the original Note; 

  
 3 

	 	(4)	the name and address of the Paying Agent; 

  

	 	(5)	that Notes called for redemption must be surrendered to the Paying Agent to collect the redemption price; 

 

	 	(6)	that, unless the Issuer defaults in making such redemption payment, interest and Additional Interest, if any, on Notes called for redemption ceases to accrue on and
after the redemption date; 

  

	 	(7)	the paragraph of the Notes and/or Section of this Indenture pursuant to which the Notes called for redemption are being redeemed; and 

 

	 	(8)	that no representation is made as to the correctness or accuracy of the CUSIP number, if any, listed in such notice or printed on the Notes. 

At the Issuer’s request, the Trustee shall give the notice of redemption in the Issuer’s name and at its
expense; provided, however, that the Issuer has delivered to the Trustee, at least 45 days prior to the redemption date (or such shorter period as to which the Trustee may agree), an Officer’s Certificate requesting that the
Trustee give such notice and setting forth the information to be stated in such notice as provided in the preceding paragraph. 

ARTICLE III 

AMENDMENT TO THE NOTES 
 The Notes include certain of the foregoing provisions from the Indenture to be deleted or amended pursuant to Article II hereof. Upon the Operative Date, such provisions from the Notes, and such cross
references and definitions as may relate thereto, shall be deemed deleted or amended as applicable. 

  
 4 

 SIGNATURES 
 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly executed all as of the date first written above. 

 

			
	 UNITED SURGICAL PARTNERS
 INTERNATIONAL, INC.,
     as the Company

		
	By:	 	/s/ Mark A. Kopser
	Name:	 	Mark A. Kopser
	Title:	 	Executive Vice President and Chief Financial Officer

  

 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly executed all as of
the date first written above. 
  

			
	 U.S. BANK NATIONAL ASSOCIATION,
     as the Trustee

		
	By:	 	/s/ Donald T. Hurrelbrink
	Name:	 	Donald T. Hurrelbrink
	Title:	 	Vice PresidentExhibit 10.7

 Exhibit 10.7 
 Lease Agreement 
 This Lease is entered into as of this
    1st     day of         January, 2012_, by and between American Yorkshire Club (hereinafter referred to as “lessor”), and
    ENDOCYTE INC. (Hereinafter referred to as “Lessee”). 
 Witnesseth:

 Now, therefore, in consideration of the premises, the parties hereto covenant and agree as follows: 

 

	 	1.	Leased Premises. Lessor hereby leases to Lessee, and Lessee hereby accepts in an “as is” condition and leases from Lessor, the space of
approximately 19’7” X 21’ 3” including 1 bath and storage areas (encompassing two office spaces) referred to as the Building at [*] (such office spaces hereinafter referred to as the “Leased Premises”). Lessee is hereby
granted the non-exclusive right to use the walkways, drive, and other common facilities which are intended for common use by tenants in the building, their customers, employees, agents and invitees, but subject to the other terms of this Lease as to
parking. 

  

	 	2.	Term. The term of this Lease shall be for a period commencing January 1, 2012, and continuing until December 31,
2012. 

  

	 	3.	 Rental. That the Lessee shall pay as rent for the leased premises the sum of One Thousand Six hundred, Sixty-Five dollars and 50
cents ($1665.50) per month beginning January 1, 2012, which rent shall be due on the first of each month. The rent shall be paid to Lessor without notice or demand and without abatement, deduction or set-off, except as
herein otherwise provided. Rent shall increase three percent (3%) per year beginning January 1, 2012 and each January 1 thereafter. Lessee agrees to pay a late charge of $75.00 for any rents received after the
3rd of the month due by Lessor. All rental checks shall be
made payable to American Yorkshire Club and shall be sent to 2639 Yeager Road, West Lafayette, IN 47906. 

 Renewal. This lease will automatically renew itself for a one-year period beginning on 
 January 1, 2013 at a rental rate to be increased by three (3%) per year, but may be terminated by either party giving notice to the other in writing not less than 120 days prior to
the expiration of the lease. 
  

	 	4.	Use of Leased Premises. Lessee shall use the Leased Premises for the purpose of a [*] and related activates and for no other purposes unless the written
consent of the owner is first obtained. IT IS AGREED THAT NO SMOKING SHALL BE PERMITTED IN THE LEASED PREMISES OR WITHIN THE BUILDING OF WHICH IT IS A PART. 

 

	 	5.	Signs and Lights. Lessee shall not construct or place signs, exterior lighting, or other structures projecting from the exterior of the Leased Premises or
the building without the written consent of the Lessor. At expiration or termination of this lease, Lessee shall remove all signs or other structures at Lessee’s expense, and shall repair any damage caused by such removal.

	 	6.	Repair and Maintenance. Lessee has inspected the Leased Premises and accepts it as in a leasable and good condition. Lessee shall, at Lessee’s sole
cost and expense, repair and maintain the Leased Premises in excess of ordinary wear and tear. The Lessor shall at all times during the term of the Lease maintain and repair the building of which the Leased Premises are a part, and shall also
maintain and repair the common areas, including the sidewalks, drive and parking area. 

  

	 	7.	Alterations. Lessee shall make no alterations, improvement, or changes to the Leased Premises without the prior written consent of the Lessor. Any
authorized alterations, improvements or changes shall be at the expense of the Lessee and shall become the property of the Lessor and remain on the Leased Premises at expiration or termination of this Lease. 

 

	 	a)	Lessee shall be permitted to replace keyed entry and have sole access to leased premises. Lessor upon notification shall have right to enter leased premises to check
maintenance of area, to show property to insurance or lending representative, or for emergencies. This will be done in a manner so as not to interfere with research conditions. 

 

	 	b)	Lessee shall be permitted to install a stainless steel sink in place of utility sink. 

 

	 	c)	Lessee shall be permitted to install a fume hood system and an HVAC system by Lafayette Heating and Cooling. System will be next to system currently installed. All
plans and specifications shall be approved in writing by Lessor prior to any installation. 

  

	 	d)	Lessee shall be permitted to restrict natural light into room by covering windows in the manner to be approved prior to installation. All materials viewed from exterior
are to be white. 

  

	 	e)	Lessee shall be permitted to seal off doorway leading into Lessor’s adjoining space. 

 

	 	f)	All alterations permitted in items (a) through (e) shall be at the expense of the Lessee and all permanently attached fixtures, (i.e. furnace, etc) shall
remain intact with the property at termination of the lease. 

  

	 	8.	Indemnification and Liability Insurance. Lessor and their agents and employees shall have no liability to Lessee for any injury of damages to Lessee, his
agents, employees, clients or customers, or to any property of Lessor, their agents and employees harmless from and against any and all liability, damages, expenses, fees, penalties, actions, causes or actions, suits, costs, claims or judgments
arising from injury during the term of this Lease to any persons or property in or about the Leased Premises from any cause whatsoever. Lessee shall procure and maintain during the term of the Lease public liability and property damage insurance
with respect to the Leased Premises and Lessee’s use and occupancy thereof, insuring Lessor and Lessee from all causes, including their own negligence, naming Lessor as an additional insured and having minimum limits of liability of $1,000,000.
Such policy shall contain a clause that the insurer will not cancel or change the insurance without first giving Lessor and Lessee thirty (30) days prior written notice. Lessee shall deliver to Lessor a copy of the policy or a certificate of
insurance maintained pursuant to this paragraph. If Lessee fails to procure such insurance, Lessor may at their option procure the same for Lessee and Lessee shall pay the cost to Lessor as additional rent as billed. 

	 	9.	Casualty Insurance. All casualty or fire and extended coverage insurance which may be carried by Lessor with respect to the building, including the Leased
Premises, or the property of the Lessor located therein, shall be endorsed with a clause permitting waiver of rights of recovery from Lessee for any loss is or could have been insured by valid and collectible fire and extended coverage insurance
policies in standard from containing such a waiver of claims endorsement. Lessee shall be liable to Lessor for the cost of repairing any damage to the Leased Premises or to the building of which it is a part caused by the act of neglect of Lessee,
his agents, employees or invitees, to the extent such damage is not insured or insurable by Lessor under standard fire and extended coverage insurance policies containing customary deductible provisions. 

 

	 	10.	Damage or Destruction. If fifty percent (50%) or more of the Leased Premises are damaged or made unleaseable by fire or other casualty and Lessor
elects not to restore it, then Lessor may, by writte4n notice to Lessee given within thirty (30) days after the date of such casualty, terminate this Lease. Lessor shall be under no duty or obligation to repair, restore or rebuild the same.
Such termination shall become effective as of the date of the casualty of the Leased Premises unleaseable, otherwise as of a date thirty days following the service of the notice of lease termination. Unless this Lease is terminated as hereinabove
provided, Lessor shall restore all damaged portions of the Leased Premises at Lessor’s expense with promptness except for Lessee’s improvements, which shall be restored at the expense of the Lessee. In the event of termination of this
Lease, rent shall be prorated on a per diem (30-day month) basis and paid only to effective date of such termination. If the Leased Premises are unleaseable but this Lease is not terminated, all rent shall abate from the casualty date until the
Leased Premises are substantially restored and reasonably accessible for occupancy by Lessee, if part of the Leased Premises are unleaseable, rent shall be prorated on a per diem basis and apportioned in accordance with the part of the Leased
Premises which is usable by Lessee until the damaged part is ready for Lessee’s occupancy. In all cases, due allowance shall be made for reasonable control. Lessor shall have no duty to repair, restore, or replace Lessee improvements, including
but not limited to wall and floor coverings, light fixtures, built-in cabinets and bookshelves, and to the contrary in this Lease, the Lessee shall not have the right to terminate this Lease and shall not abate if the casualty was caused by the act
of neglect of Lessee or his employees, agents or invitees. 

  

	 	11.	Utilities and Janitorial Service. Lessee shall pay for all their utilities. Lessee shall pay for all charges for other utility services for the Leased
Premises, including telephone, and CATB (including meter deposits), and for any janitorial services. Lessee shall remove all waste materials from Leased Premises twice a week. Waste will be disposed of off-site of American Yorkshire Club property.

  

	 	12.	Real Estate Taxes. Lessor shall pay all real estate taxes for the Leased Premises and the building of which the Leased Premises are a part.

  

	 	13.	Assignment and Subletting. Lessee shall not assign this Lease nor any rights hereunder not sublet the Leased Premises, in whole or in part, nor allow any
other person to occupy or use the leased premises without the prior written consent of the Lessor. In any event, Lessee shall remain fully liable to perform all of the terms and provisions of this Lease. 

 

	 	14.	Events of Default by Lessee. The occurrence of any one or more of the following events constitutes a default (“Default”) by Lessee under this
Lease: 

  

	 	a.	Failure by Lessee to pay any installment of rent when the same is due and the failure continues for five (5 days): 

 

	 	b.	Failure by Lessee to pay, within ten (10) days after written notice from Lessor, any other sums due and payable from Lessee to Lessor under this lease.

  

	 	c.	Failure by Lessee to cure forthwith, promptly after receipt of notice from Lessor, any Hazardous conditions which Lessee has created in violation of law of or this
Lease. 

  

	 	d.	Failure by Lessee to observe or perform any other covenant, term of condition of this Lease if such failure continues for thirty (30) days after written notice to
Lessee by Lessor, unless the nonobservance of nonperformance is of a nature that it cannot be corrected in thirty days and Lessee has commenced observance or performance and is pursuing it with diligence. 

 

	 	e.	The levy upon under execution or the attachment by legal process or the leasehold interest of Lessee, or the filing or creations of a lien in respect of such leasehold
interest which Lessee does not discharge within thirty days. 

  

	 	f.	Failure by Lessee to observe or perform any of the covenants in respect to assignment and subletting; 

 

	 	g.	Lessee vacates or abandons the Leased Premises; 

  

	 	h.	Lessee becomes insolvent or bankrupt or admits in writing his inability to pay his debts as they mature, or makes an assignment for the benefit or creditors, or applies
for or consents to the appointment of a trustee or receiver for Lessee or the major part of his property; 

  

	 	i.	A trustee or receiver is appointed for Lessee or for the major part of its property and is not discharged within thirty days after such appointment;

  

	 	j.	Any proceedings for relief under any bankruptcy law, or similar law for relief of debtors, are instituted by or against Lessee, and if instituted against Lessee, are
allowed against him or are consented to by him, or are not dismissed within sixty days after such institution. 

  

	 	15.	Lessor’s Remedies Upon Default. Upon the occurrence of any Default by lessee, Lessor shall have the rights and remedies hereinafter set forth, which
shall be distinct, separate and cumulative and shall not operate to exclude or deprive Lessor of any other rights or remedy allowed them by law. 

  

	 	a.	Lessor may terminate this Lease by giving written notice of Lessor’s intention so to do, in which event the term shall end, and all right, title and interest of
the Lessee hereunder shall expire on the date stated in such notice; 

  

	 	b.	Lessor may terminate the right of Lessee to possession of the Leased Premises without terminating this Lease by giving written notice to Lessee that Lessee’s right
of Lessee to possession of the Lease Premises or any part thereof shall cease on the date stated in such notice; and 

  

	 	c.	Lessor may enforce the provisions of this Lease and may enforce and protect the rights of Lessor hereunder by a suits in equity or at law for the specific performance
of any covenant or agreement contained herein, or for the enforcement of any other appropriate legal or equitable remedy, including recovery of all monies due or to become due from Lessee under any of the provisions of this Lease.

  

	 	d.	 If the Lessor exercises either of the remedies provided in subparagraphs (a) and (b) of this paragraph, Lessee shall surrender possession and
vacate the Leased Premises immediately and deliver possession thereof to Lessor, and Lessor may then or at any 

	 	
time thereafter re-enter and take complete license so to do being hereby granted to Lessor, and Lessor may remove all occupants and property therefrom, using such force as may be necessary,
without being deemed in any manner guilty of trespass, eviction or forcible entry and detainer and without relinquishing Lessor hereunder of by operation of law. If the Lessor terminates the right of Lessee to possession of the Leased Premises
without terminating this Lease, such termination of possession shall not release Lessee, in whole or part, from Lessee’s obligation to pay the rental hereunder for the full lease term, and the aggregate amount of the base rent for the period
from the date stated in the notice termination of possession to the end of the term of this Lease shall at once mature and be immediately due and payable by Lessee to Lessor, together with any and all other monies due hereunder, and Lessor shall
have the right to immediate recovery of all such amounts. In addition, Lessor shall have the right, from time to time, to recover from Lessee, and Lessee shall remain liable for, all additional rent and any other sums thereafter accruing as they
become due under this Lease during the period from the date of such notice of termination of possession to the stated end of the term of this Lease. 

  

	 	e.	If this Lease is terminated by Lessor as provided for by subparagraph (a) of this paragraph, Lessor shall be entitled to recover from Lessee all the fixed basic
rent accrued and unpaid for the period up to and including such termination date, as well as all other additional sums payable by Lessee, or for which Lessee is liable or in respect of all of which Lessee has agreed to indemnify Lessor under any of
the provisions of the Lease, which may be then owing and unpaid, and all costs and expenses, including court costs and attorney fees incurred by Lessor in the enforcement of (its) rights and remedies hereunder; and in addition, Lessor shall be
entitled to recover as damages an amount equal to the remaining rents for the remainder of the term of this Lease, as well as all other additional sums payable by Lessee, or for which Lessee is liable or in respect of which Lessee had agreed to
indemnify Lessor under any of the provisions of this Lease had this Lease not been terminated. In addition, Lessor makes repairs, alterations, and additions in or to the Leased Premises and redecorates the same to the extent deemed by the Lessor
necessary or desirable and in connection therewith change locks to the Leased Premises, and Lessee shall be liable for the costs thereof. Lessor may collect the rents from any reletting, if any, and apply the same first to the expenses of re-entry,
redecoration, repairs and alterations and the expenses of reletting, and second to the payment of rental herein provided to be paid Lessee, and any excess or residue shall operate only as offsetting credit against the amount of rental as the same
thereafter becomes due and payable hereunder, but Lessee shall have no right, title or interest in such excess or residue and it shall belong to Lessor solely; provided, that in no event shall Lessee be entitled to a credit on indebtedness to Lessor
in excess of the aggregate sum which would have been paid by Lessee for the period for which the credit to Lessee is being determined, had no Default occurred 

 

	 	16.	 Surrender of Premises. At the expiration of the term of this Lease, Lessee shall peaceably deliver up to Lessor possession of the Leased
Premises, together will all improvements and additions upon, by whomsoever made except as provided, in the same condition as received, ordinary wear and tear, condemnation, and damage by casualty excepted. Upon termination of the Lease, Lessee shall
at Lessee’s expense, remove all 

	 	
trade fixtures, office furniture and equipment installed by Lessee, unless otherwise agreed to in writing by Lessor. Lessee shall also repair any damage caused by such removal. Property not so
removed shall be deemed abandoned at the expiration of the term of the Lease by Lessee and title thereto shall thereupon pass to Lessor. Lessee shall indemnify Lessor against any loss or liability resulting from delay by Lessee in so surrendering
the Leased Premised, including without limitation, any claims made by any succeeding Lessee founded on such delay. 

  

	 	17.	Holding Over. Any holding over after the expiration of this Lease with the Consent of the Lessor shall be construed to be a tenancy from month to month,
at the same monthly rental and upon the same remaining terms of this Lease, so far as applicable. 

  

	 	18.	Security Deposit. Lessee has deposited with Lessor the sum of Six-Hundred and Fifty Dollars ($650) the receipt of which is acknowledged by
Lessor, as security for the full and faithful performance of each term, provision, covenant, and condition of this Lease. In the event Lessee defaults in respect of any of the terms, provisions, covenants, or conditions hereof, including but not
limited to payment of rent, Lessor may use, apply, or retain the whole of any part of such security for the payment of any rent in default or for any other sum which Lessor may spend or be required to spend by reason of Lessee’s default. If
Lessee shall comply fully with the terms of this lease, the security or any balance thereof shall be returned to Lessee. Lessee shall not be entitled to any interest on such security deposit. If Lessor sells the Leased Premises or the real estate of
which it is a part. Lessor may transfer or deliver the security, as such, to the purchaser, and thereupon the Lessor shall be discharged from any further liability in reference thereto. 

 

	 	19.	Waiver. The waiver by Lessor of any term, covenant, or condition of this Lease shall be in writing, and a waiver or failure of the Lessor to take action
with respect to any breach of any term, covenant or condition shall not be deemed to be a waiver of such term, covenant or condition herein contained. The subsequent acceptance of rent hereunder by Lessor shall not be deemed to be a waiver of any
preceding breach by Lessee of any term, covenant, or condition of this Lease, other than the failure of Lessee to any particular rental so accepted, regardless of Lessor’s knowledge of such preceding breach at the time of acceptance of such
rent. 

  

	 	20.	Parking Area. The Lessor shall make available such common area for up to two (2) vehicles of the Lessee and his employees, agents, customers and
invitees as the Lessor deems appropriate. Such persons shall have the non-exclusive right, in common with the Lessor and all others to whom the Lessor has or may hereafter grant such right. To use such areas, subject to such rules and regulations as
the Lessor may from time to time impose including the requirement for the parking of vehicles of Lessee and his employees, and agents in designated areas of the parking lot. Lessee covenants and agrees to follow and abide by such rules and upon
request to furnish to Lessor the make and license numbers of the vehicles and to furnish to Lessor the make and license numbers of the vehicles and the vehicles of his employees, and agents. Lessor shall have the right to enforce such rules and
regulations by either towing such vehicles or the imposition of fines of twenty-five dollars ($25.00) per violation. Such towing charges of fines shall be deemed additional rent and shall be payable with the next installment of rent after notice of
such charge or fine. 

  

	 	21.	Notices. All notices required under this Lease shall be in writing and given in person or sent certified mail, return receipt requested, as follows:

	 	a.	If to Lessor, at 2639 Yeager Road, West Lafayette, IN 47906 

  

	 	b.	If to Lessee at: 

Endocyte 
 3000 Kent Avenue 
 Suite A1-1000 

West Lafayette, IN 47906 
 or at such other address as may be given by either party in writing, in person by certified mail. Notice, if made by certified mail, shall be deemed given on date of postmark. 

 

	 	22.	Quiet Enjoyment. Lessor covenants that Lessee, upon payment of the rental and performance of the terms and conditions of this Lease, shall peacefully and
quietly hold, occupy and enjoy the Leased Premises and drive and parking area throughout the term hereof. 

  

	 	23.	Accord and Satisfaction. Lessor is entitled to accept, receive and cash and deposit any payment made by Lessee for any reason or purpose or in any amount
whatsoever, and apply the same at Lessor’s option to any obligation of Lessee and the same shall not constitute payment of any amount owed except that to which Lessor has applied the same. No endorsement or statement on any check or letter of
Lessee shall be deemed an accord and satisfaction or otherwise recognized for any purpose whatsoever. The acceptance of any such check or payment shall be without prejudice to Lessor’s right to recover any and all amounts owed by Lessee
hereunder and Lessor’s right to pursue any other available remedy. 

  

	 	24.	Severability. If any term or provision of the Lease shall to any extent be held invalid or unenforceable, the remaining terms and provisions of this Lease
shall not be affected thereby, but each term and provision of this Lease shall be valid and enforceable to the fullest extent permitted by law. 

  

	 	25.	Cost and Expenses. Lessee shall pay cost and expenses, including court costs and attorney’s fees, incurred by Lessor in enforcing any of the
obligations of this Lease or incurred by Lessor in any litigations, negotiation or transaction relating to, or arising out of, this Lease in which Lessor, without fault, becomes involved or concerned. 

 

	 	26.	Binding Effect. This Lease shall be binding upon and insure to the benefit of the parties hereto and their respective heirs, personal representative,
successors, and permitted assigns. If Lessee is more than one person, the liability of each such person shall be joint and several. 

  

	 	27.	Entire Agreement. This Lease constitutes the entire agreement between the parties and may not be modified except in writing, signed by both parties.

  

	 	28.	Applicable Law. This Lease shall be construed and enforced in accordance with the laws of the State of Indiana. 

In Witness Whereof, the parties have executed this instrument as of the date first above written. 

					
	LESSOR:	 		 	
			
	American Yorkshire Club	 		 	
			
	/s/ Clint Schwab	 		 	December 9, 2011
		 		 	 DATE

	LESSEE:	 		 	
			
	/s/ Beth A. Taylor	 		 	December 2, 2011
		 		 	 DATE

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