Document:

EX-10.40

 Exhibit 10.40 

SUBSCRIPTION AGREEMENT 
 CONSTELLATION
ALPHA CAPITAL CORP. 
 Emerald View, Suite 400 
 2054 Vista
Parkway 
 West Palm Beach, FL 33411 
 Ladies and Gentlemen:

 In connection with the proposed business combination (the “Transaction”) in which DermTech, Inc., a
Delaware Corporation (“DermTech”) will merge with a wholly-owned subsidiary corporation of Constellation Alpha Capital Corp., a company incorporated in the British Virgin Islands and which is expected to re-domicile in the State of Delaware (the “Company”), the undersigned desires to subscribe for and purchase from the Company, and the Company desires to sell to the undersigned, that number of
shares of common stock (the “Company Shares”) of the Company set forth on the signature page hereof for a purchase price of $3.25 per share, on the terms and subject to the conditions contained herein. In connection therewith, the
undersigned and the Company agree as follows: 
 1. Subscription. The undersigned hereby irrevocably subscribes for
and agrees to purchase from the Company such number of Company Shares as is set forth on the signature page of this Subscription Agreement on the terms and subject to the conditions provided for herein (the “Shares”). The
undersigned understands and agrees that the Company reserves the right to accept or reject the undersigned’s subscription for the Shares for any reason or for no reason, in whole or in part, at any time prior to its acceptance by the Company,
and the same shall be deemed to be accepted by the Company only when this Subscription Agreement is signed by a duly authorized person by or on behalf of the Company; the Company may do so in counterpart form. In the event of rejection of the
subscription (in whole or in part) by the Company or the termination of this subscription in accordance with the terms hereof, the undersigned’s payment hereunder will be returned promptly (within three (3) days) to the undersigned along
with this Subscription Agreement, and this Subscription Agreement shall have no force or effect. The Company expects to enter into substantially this same form of subscription agreement with certain other investors (the “Other
Purchasers”) and expects to complete the sale of Company Shares to them. 
 2. Closing. The closing of the
sale of the Shares contemplated hereby (the “Closing”) is contingent upon the substantially concurrent consummation of the Transaction. The Closing shall occur on the date of, and immediately prior to, the consummation of the
Transaction. Following written notice from (or on behalf of) the Company to the undersigned (the “Closing Notice”) that the Company reasonably expects (i) all conditions to the closing of the Transaction to be satisfied or
waived and (ii) the Closing to occur on a date that is not less than ten (10) business days from the date of the Closing Notice, the undersigned shall deliver to the Company, no sooner than three (3) business days prior to the
anticipated Closing date specified in the Closing Notice (the “Closing Date”), the subscription amount for the Shares by wire transfer of United States dollars in immediately available funds to the account specified by the Company
in the Closing Notice against delivery to the undersigned of the Shares in book entry form as set forth in the following sentence. The Company shall deliver (or cause the delivery of) the Shares in book entry form to the undersigned or to a
custodian designated by undersigned, as applicable, as indicated below. This Subscription Agreement shall terminate and be of no further force or effect, without any liability to either party hereto, if the Company notifies the undersigned in
writing that it has abandoned its plans to move forward with the Transaction. If this Subscription Agreement terminates following the delivery by the undersigned of the purchase price for the Shares, the Company shall promptly return the purchase
price to the undersigned. 
 3. Closing Conditions. The Closing is also subject to the conditions that, on the Closing
Date: 
 a. all representations and warranties of the Company and the undersigned contained in this Subscription Agreement
shall be true and correct in all material respects (other than representations and warranties that are qualified as to materiality or Material Adverse Effect (as defined herein), which representations and warranties shall be true in all respects) at
and as of the Closing Date, and consummation of the Closing shall constitute a reaffirmation by each of the Company and the undersigned of each of the representations, warranties 

 
and agreements of each such party contained in this Subscription Agreement as of the Closing Date, but in each case without giving effect to consummation of the Transaction; 

b. no governmental authority shall have enacted, issued, promulgated, enforced or entered any judgment, order, law, rule or
regulation (whether temporary, preliminary or permanent) which is then in effect and has the effect of making consummation of the transactions contemplated hereby illegal or otherwise restraining or prohibiting consummation of the transactions
contemplated hereby, and no governmental authority shall have instituted or threatened in writing a proceeding seeking to impose any such restraint or prohibition; 

c. the Company is a company incorporated under the laws of the State of Delaware and will be treated as a U.S. corporation for
U.S. federal income tax purposes; 
 d. there have been no material changes to the material terms of the Transaction set
forth on Schedule D; 
 e. all conditions precedent to the closing of the Transaction, including the approval of the
Company’s stockholders, shall have been satisfied or waived (other than those conditions which, by their nature, are to be satisfied at the closing of the Transaction); and 

f. no suspension of the qualification of the Shares for offering or sale or trading in any jurisdiction, or initiation or
threatening of any proceedings for any of such purposes, shall have occurred. 
 4. Further Assurances. At the
Closing, the parties hereto shall execute and deliver such additional documents and take such additional actions as the parties reasonably may deem to be practical and necessary in order to consummate the subscription as contemplated by this
Subscription Agreement. 
 5. Company Representations and Warranties. The Company represents and warrants to the
undersigned that, as of the date hereof and as of the Closing: 
 a. The Company has been duly organized, is validly existing
and is in good standing under the laws of the jurisdiction of its formation or incorporation, with corporate power and authority to own, lease and operate its properties and conduct its business as presently conducted. 

b. The Shares have been duly authorized and, when issued and delivered to the undersigned against full payment therefor in
accordance with the terms of this Subscription Agreement, the Shares will be validly issued, fully paid and non-assessable and will not have been issued in violation of or subject to any preemptive or similar
rights created under the Company’s governance documents or under the laws of the jurisdiction under which it has been organized. 

c. The execution, delivery and performance by the Company of this Subscription Agreement are within its powers, have been duly
authorized and will not constitute or result in a breach or default under or conflict with any order, ruling or regulation of any court or other tribunal or of any governmental commission or agency, or any agreement or other undertaking, to which
the Company is a party or by which the Company is bound, and will not violate any provisions of the Company’s charter documents, including, without limitation, its incorporation or formation papers and bylaws. The signature on this Subscription
Agreement by the Company is genuine, and the signatory has been duly authorized to execute the same, and this Subscription Agreement constitutes a legal, valid and binding obligation of the Company, enforceable against it in accordance with its
terms, except as may be limited or otherwise affected by (i) bankruptcy, insolvency, fraudulent conveyance, reorganization, moratorium or other laws relating to or affecting the rights of creditors generally, and (ii) principles of equity,
whether considered at law or equity. 
 d. The issuance and sale of the Shares and the compliance by the Company with all of
the provisions of this Subscription Agreement and the consummation of the transactions herein will not conflict with or result in a breach or violation of any of the terms or provisions of, or constitute a default under, or result in the creation or
imposition of any lien, charge or encumbrance upon any of the property or assets of the Company 

  
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or any of its subsidiaries pursuant to the terms of (i) any indenture, mortgage, deed of trust, loan agreement, lease, license or other agreement or instrument to which the Company or any of
its subsidiaries is a party or by which the Company or any of its subsidiaries is bound or to which any of the property or assets of the Company is subject, which would have a material adverse effect on the business, properties, financial condition,
stockholders’ equity or results of operations of the Company (a “Material Adverse Effect”) or affect the validity of the Shares or the legal authority of the Company to comply in all material respects with the terms of this
Subscription Agreement; (ii) result in any violation of the provisions of the organizational documents of the Company; or (iii) result in any violation of any statute or any judgment, order, rule or regulation of any court or governmental
agency or body, domestic or foreign, having jurisdiction over the Company or any of its properties that would have a Material Adverse Effect or affect the validity of the Shares or the legal authority of the Company to comply with this Subscription
Agreement. 
 e. The Company is subject to the reporting requirements of the Securities Exchange Act of 1934, as amended (the
“Exchange Act”), and has filed all reports required thereby. To the Company’s knowledge, there exist no facts or circumstances that reasonably could be expected to prohibit or delay the preparation and filing of a Securities
Act registration statement on Form S-3 that will be available for the resale of the Shares by the undersigned as contemplated by Section 7 below. 

f. As of the date of this Subscription Agreement, the authorized shares of capital stock of the Company consists of an
unlimited number of shares of common stock and an unlimited number of shares of preferred stock. As of the date of this Subscription Agreement, (i) 4,155,000 shares of Company common stock are issued and outstanding (which excludes 1,187,532 shares
subject to redemption rights provided in the amended and restated articles of association of the Company), all of which are validly issued, fully paid and non-assessable, (ii) no shares of Company common
stock are held in treasury, (iii) the Company has reserved for future issuance 7,468,125 shares of Company common stock pursuant to outstanding warrants, and (iv) the Company has reserved for future issuance 1,493,625 shares of Company
common stock pursuant to outstanding rights. As of the date of this Subscription Agreement, there are no shares of Company preferred stock issued and outstanding. Except for the warrants and rights mentioned above, there are no options, warrants or
other rights, agreements, arrangements or commitments of any character relating to the issued or unissued capital stock of the Company or obligating the Company to issue or sell any shares of capital stock of, or other equity interests in, the
Company. There are no outstanding contractual obligations of the Company to repurchase, redeem or otherwise acquire any shares of Company common stock, except for the redemption rights described above. There are no outstanding contractual
obligations of the Company to provide funds to, or make any investment (in the form of a loan, capital contribution or otherwise) in, any person. The Company has issued promissory notes in the amounts and to the parties set forth in Schedule
E. 
 g. There are no suits, proceedings or legal or governmental actions pending, or to the Company’s knowledge,
threatened, before any court, regulatory body or administrative agency, or any other governmental agency or body, which suits, proceedings or actions, individually or in the aggregate, could reasonably be expected to have a Material Adverse Effect.
The Company is not a party to or subject to the provisions of any injunction, judgment, decree or order of any court, regulatory body administrative agency or other governmental agency or body that could reasonably be expected to have a Material
Adverse Effect. 
 h. Since December 31, 2018, (i) there has not been any change in the capital stock of the Company
(other than the sale of the Shares hereunder, the sale of additional Company Shares to the Other Purchasers, Company Shares redeemed in connection with the Company’s special meeting of shareholders held on March 21, 2019 to approve an
extension to the amount of time it has to complete a business combination and the issuance of Company Shares pursuant to the Transaction, in each case as of the Closing), and (ii) there has not occurred any event that has caused or reasonably
could be expected to cause a Material Adverse Event. 
 i. None of the following documents contained or contains a an untrue
statement of a material fact or omitted or omits to state a material fact required to be stated therein, or necessary to make the statements therein, in light of the circumstances in which they were made, not misleading: (i) the Company’s
Annual Report on Form 10-K for the fiscal year ended March 31, 2018; (ii) the Company’s Quarterly Reports on Form 10-Q for the fiscal quarters ended
June 30, 2018, September 30, 2018 and December 31, 2018; (iii) the Company’s Current Reports on Form 8-K filed with the Securities and Exchange Commission (the “SEC”) on

  
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August 3, 2018, December 4, 2018, February 28, 2019, March 15, 2019 and March 25, 2019; (iv) all other documents filed by the Company with the SEC since the filing of the
above-mentioned Form 10-K; and (v) the Disclosure Package (as defined below). In the past 12 calendar months, the Company has filed all documents required to be filed by it prior to the date hereof with
the SEC pursuant to the reporting requirements of the Exchange Act. 
 j. The financial statements of the Company and the
related notes and schedules thereto included in the Company’s Exchange Act filings fairly present in all material respects the financial position, results of operations, stockholders’ equity and cash flows of the Company as of the dates
and for the periods specified therein. Such financial statements and the related notes and schedules thereto have been prepared in accordance with generally accepted accounting principles consistently applied throughout the periods involved and all
adjustments necessary for a fair presentation of results for such periods have been made; provided, however, that the Company’s unaudited financial statements are subject to normal year-end
adjustments. 
 k. Except as described in the Company’s Current Report on Form
8-K filed with the SEC on February 28, 2019, the Company is in compliance with the requirements of the NASDAQ Capital Market (“Nasdaq”) for continued listing thereon of the Company
Shares. The Company has taken no action designed to, or likely to have the effect of, terminating the registration of the Company Shares under the Exchange Act or the listing of the Company Shares on Nasdaq, nor, except as disclosed in the
Company’s Current Report on Form 8-K filed with the SEC on February 28, 2019, has the Company received any notification that the SEC or Nasdaq is contemplating terminating such registration or
listing. The transactions contemplated by this Subscription Agreement will not contravene the rules and regulations of Nasdaq. The Company will comply with all requirements of Nasdaq with respect to the issuance of the Shares hereunder and the
issuance of Company Shares to the Other Purchasers, and shall cause the Shares to be approved for listing on Nasdaq (and any other exchange on which the Company Shares are listed for trading) not later than the Closing. 

6. Subscriber Representations and Warranties. The undersigned represents and warrants to the Company
that, as of the date hereof and as of the Closing: 
 a. The undersigned is (i) a “qualified institutional
buyer” (as defined in Rule 144A under the Securities Act of 1933, as amended (the “Securities Act”)) or (ii) an institutional “accredited investor” (within the meaning of Rule 501(a) under the Securities Act), in
each case, satisfying the requirements set forth on Schedule A, and is acquiring the Shares only for his, her or its own account and not for the account of others, and not on behalf of any other account or person or with a view to, or for
offer or sale in connection with, any distribution thereof in violation of the Securities Act (and shall provide the requested information on Schedule A following the signature page hereto). The undersigned is not an entity formed for the
specific purpose of acquiring the Shares. 
 b. The undersigned understands that the Shares are being offered in a
transaction not involving any public offering within the meaning of the Securities Act and that the Shares have not been registered under the Securities Act. The undersigned understands that the Shares may not be resold, transferred, pledged or
otherwise disposed of by the undersigned absent an effective registration statement under the Securities Act except (i) to the Company or a subsidiary thereof, (ii) to non-U.S. persons pursuant to
offers and sales that occur outside the United States within the meaning of Regulation S under the Securities Act or (iii) pursuant to another applicable exemption from the registration requirements of the Securities Act, and in each of cases
(i) and (iii) in accordance with any applicable securities laws of the states and other jurisdictions of the United States, and that any certificates representing the Shares shall contain a legend to such effect. The undersigned acknowledges
that the Shares will not be eligible for resale pursuant to Rule 144A promulgated under the Securities Act. The undersigned understands and agrees that the Shares will be subject to transfer restrictions and, as a result of these transfer
restrictions, the undersigned may not be able to readily resell the Shares and may be required to bear the financial risk of an investment in the Shares for an indefinite period of time. The undersigned understands that it has been advised to
consult legal counsel prior to making any offer, resale, pledge or transfer of any of the Shares. 
 c. The undersigned
understands and agrees that the undersigned is purchasing Shares directly from the Company. The undersigned further acknowledges that there have been no representations, warranties, covenants and agreements made to the undersigned by the Company, or
its officers or directors, 

  
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expressly or by implication, other than those representations, warranties, covenants and agreements included in this Subscription Agreement. 

d. The undersigned’s acquisition and holding of the Shares will not constitute or result in a non-exempt prohibited transaction under Section 406 of the Employee Retirement Income Security Act of 1974, as amended, Section 4975 of the Internal Revenue Code of 1986, as amended, or any applicable
similar law. 
 e. The undersigned acknowledges and agrees that the undersigned has received such information as the
undersigned deems necessary in order to make an investment decision with respect to the Shares. Without limiting the generality of the foregoing, the undersigned acknowledges that it has reviewed the disclosure package attached hereto as Schedule
C (the “Disclosure Package”). The undersigned represents and agrees that the undersigned and the undersigned’s professional advisor(s), if any, have had the full opportunity to ask such questions, receive such answers and
obtain such information as the undersigned and such undersigned’s professional advisor(s), if any, have deemed necessary to make an investment decision with respect to the Shares. The undersigned further acknowledges that the information
contained in the Disclosure Package is preliminary and subject to change, and that any changes to the information contained in the Disclosure Package, including, without limitation, any changes based on updated information or changes in terms of the
Transaction (other than the material terms set forth on Schedule D which shall not have materially changed), shall in no way affect the undersigned’s obligation to purchase the Shares hereunder. 

f. The undersigned became aware of this offering of the Shares solely by means of direct contact between the undersigned and
the Company or a representative of the Company, and the Shares were offered to the undersigned solely by direct contact between the undersigned and the Company or a representative of the Company. The undersigned did not become aware of this offering
of the Shares, nor were the Shares offered to the undersigned, by any other means. The undersigned acknowledges that the Company represents and warrants that the Shares (i) were not offered by any form of general solicitation or general
advertising and (ii) are not being offered in a manner involving a public offering under, or in a distribution in violation of, the Securities Act, or any state securities laws. 

g. The undersigned acknowledges that it is aware that there are substantial risks incident to the purchase and ownership of the
Shares, including those set forth in the Disclosure Package. The undersigned has such knowledge and experience in financial and business matters as to be capable of evaluating the merits and risks of an investment in the Shares, and the undersigned
has sought such accounting, legal and tax advice as the undersigned has considered necessary to make an informed investment decision. 

h. Alone, or together with any professional advisor(s), the undersigned has adequately analyzed and fully considered the risks
of an investment in the Shares and determined that the Shares are a suitable investment for the undersigned and that the undersigned is able at this time and in the foreseeable future to bear the economic risk of a total loss of the
undersigned’s investment in the Company. The undersigned acknowledges specifically that a possibility of total loss exists. 

i. In making its decision to purchase the Shares, the undersigned has relied solely upon independent investigation made by the
undersigned. Without limiting the generality of the foregoing, the undersigned has not relied on any statements or other information provided by the Placement Agent (as defined below) concerning the Company or the Shares or the offer and sale of the
Shares. 
 j. The undersigned understands and agrees that no federal or state agency has passed upon or endorsed the merits
of the offering of the Shares or made any findings or determination as to the fairness of this investment. 
 k. The
undersigned has been duly formed or incorporated and is validly existing in good standing under the laws of its jurisdiction of incorporation or formation. 

l. The execution, delivery and performance by the undersigned of this Subscription Agreement are within the powers of the
undersigned, have been duly authorized and will not constitute or result 

  
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in a breach or default under or conflict with any order, ruling or regulation of any court or other tribunal or of any governmental commission or agency, or any agreement or other undertaking, to
which the undersigned is a party or by which the undersigned is bound, and, if the undersigned is not an individual, will not violate any provisions of the undersigned’s charter documents, including, without limitation, its incorporation or
formation papers, bylaws, indenture of trust or partnership or operating agreement, as may be applicable. The signature on this Subscription Agreement is genuine, and the signatory, if the undersigned is an individual, has legal competence and
capacity to execute the same or, if the undersigned is not an individual the signatory has been duly authorized to execute the same, and this Subscription Agreement constitutes a legal, valid and binding obligation of the undersigned, enforceable
against the undersigned in accordance with its terms, except as may be limited or otherwise affected by (i) bankruptcy, insolvency, fraudulent conveyance, reorganization, moratorium or other laws relating to or affecting the rights of creditors
generally, and (ii) principles of equity, whether considered at law or equity. 
 m. Neither the due diligence
investigation conducted by the undersigned in connection with making its decision to acquire the Shares nor any representations and warranties made by the undersigned herein shall modify, amend or affect the undersigned’s right to rely on the
truth, accuracy and completeness of the Company’s representations and warranties contained herein. 
 n. The undersigned
is not (i) a person or entity named on the List of Specially Designated Nationals and Blocked Persons administered by the U.S. Treasury Department’s Office of Foreign Assets Control (“OFAC”) or in any Executive Order
issued by the President of the United States and administered by OFAC (“OFAC List”), or a person or entity prohibited by any OFAC sanctions program, (ii) a Designated National as defined in the Cuban Assets Control Regulations,
31 C.F.R. Part 515, or (iii) a non-U.S. shell bank or providing banking services indirectly to a non-U.S. shell bank (collectively, a “Prohibited
Investor”). The undersigned agrees to provide law enforcement agencies, if requested thereby, such records as required by applicable law, provided that the undersigned is permitted to do so under applicable law. If the undersigned is a
financial institution subject to the Bank Secrecy Act (31 U.S.C. Section 5311 et seq.) (the “BSA”), as amended by the USA PATRIOT Act of 2001 (the “PATRIOT Act”), and its implementing regulations (collectively,
the “BSA/PATRIOT Act”), the undersigned maintains policies and procedures reasonably designed to comply with applicable obligations under the BSA/PATRIOT Act. To the extent required, it maintains policies and procedures
reasonably designed for the screening of its investors against the OFAC sanctions programs, including the OFAC List. To the extent required, it maintains policies and procedures reasonably designed to ensure that the funds held by the undersigned
and used to purchase the Shares were legally derived. 
 o. No disclosure or offering document has been prepared by Cowen and
Company, LLC (the “Placement Agent”) or any of its affiliates in connection with the offer and sale of the Shares. 

p. The Placement Agent and its directors, officers, employees, representatives and controlling persons have made no independent
investigation with respect to the Company or the Shares or the accuracy, completeness or adequacy of any information supplied to the undersigned by the Company. 

q. In connection with the issue and purchase of the Shares, the Placement Agent has not acted as the undersigned’s
financial advisor or fiduciary. 
 r. If the undersigned is a resident or subject to the laws of Canada, the undersigned
hereby declares, represents, warrants and agrees as set forth in the attached Schedule B. 
 7. Registration of
Shares. The Company agrees that, within forty-five (45) calendar days after the consummation of the Transaction, the Company will file with the SEC (at the Company’s sole cost and expense) a registration statement registering such
resale (the “Registration Statement”), and the Company shall use its commercially reasonable efforts to have the Registration Statement declared effective as soon as practicable after the filing thereof; provided,
however, that the Company’s obligations to include the Shares in the Registration Statement are contingent upon the undersigned furnishing in writing to the Company such information regarding the undersigned, the securities of the
Company held by the undersigned and the intended method of disposition of the Shares as shall be reasonably requested by the Company to effect the registration of the Shares, and shall 

  
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execute such documents in connection with such registration as the Company may reasonably request that are customary of a selling stockholder in similar situations. 

8. [Reserved] 

9. Termination. This Subscription Agreement shall terminate and be void and of no further force and effect, and all
rights and obligations of the parties hereunder shall terminate without any further liability on the part of any party in respect thereof, upon the earlier to occur of (a) following the execution of a definitive agreement among the Company and
DermTech with respect to the Transaction (a “Transaction Agreement”), such date and time as such Transaction Agreement is terminated in accordance with its terms without the Transaction being consummated, (b) upon the mutual
written agreement of each of the parties hereto to terminate this Subscription Agreement, (c) if any of the conditions to Closing set forth in Section 3 of this Subscription Agreement are not satisfied or waived on or prior to the Closing
and, as a result thereof, the transactions contemplated by this Subscription Agreement are not consummated at the Closing or (d) September 24, 2019; provided that nothing herein will relieve any party from liability for any willful
breach hereof prior to the time of termination, and each party will be entitled to any remedies at law or in equity to recover losses, liabilities or damages arising from such breach. The Company shall promptly notify the undersigned of the
termination of the Transaction Agreement after the termination of such agreement. 
 10. Trust Account Waiver. The
undersigned acknowledges that the Company is a blank check company with the powers and privileges to effect a merger, asset acquisition, reorganization or similar business combination involving the Company and one or more businesses or assets. The
undersigned further acknowledges that, as described in the Company’s prospectus relating to its initial public offering dated June 19, 2017 (the “Prospectus”) available at www.sec.gov, substantially all of the
Company’s assets consist of the cash proceeds of the Company’s initial public offering and private placements of its securities, and substantially all of those proceeds have been deposited in a trust account (the “Trust
Account”) for the benefit of the Company, its public shareholders and the underwriters of the Company’s initial public offering. For and in consideration of the Company entering into this Subscription Agreement, the receipt and
sufficiency of which are hereby acknowledged, the undersigned hereby irrevocably waives any and all right, title and interest, or any claim of any kind it has or may have in the future, in or to any monies held in the Trust Account, and agrees not
to seek recourse against the Trust Account as a result of, or arising out of, this Subscription Agreement. 
 11.
Placement Agent Fee. The Company and the undersigned agree that the undersigned shall not be responsible or otherwise have any liability for the payment of any fee to the Placement Agent. The Company represents and warrants to the undersigned
that the Company has not engaged or employed any finder, broker, agent or other intermediary, other than the Placement Agent, in connection with the transactions described herein. There are no fees, commissions or compensation payable by the
undersigned to any person engaged or retained by, through or on behalf of the Company in connection with the consummation of the transactions described herein. 

12. Miscellaneous. 

a. Neither this Subscription Agreement nor any rights or obligations that may accrue hereunder (other than the Shares acquired
hereunder, if any) may be transferred or assigned by the Company or the undersigned without the consent of the other party. 

b. The Company may request from the undersigned such additional information as the Company may deem necessary to evaluate the
eligibility of the undersigned to acquire the Shares, and the undersigned shall provide such information as may reasonably be requested, to the extent readily available and to the extent consistent with its internal policies and procedures. 

c. The undersigned acknowledges that the Company, the Placement Agent and others will rely on the acknowledgments,
understandings, agreements, representations and warranties contained in this 

  
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Subscription Agreement. Prior to the Closing, the undersigned agrees to promptly notify the Company if any of the acknowledgments, understandings, agreements, representations and warranties set
forth herein are no longer accurate. The undersigned agrees that each purchase by the undersigned of Shares from the Company will constitute a reaffirmation of the acknowledgments, understandings, agreements, representations and warranties herein
(as modified by any such notice) by the undersigned as of the time of such purchase. The undersigned further acknowledges and agrees that the Placement Agent is a third-party beneficiary of the representations and warranties of the undersigned
contained in Section 6 of this Subscription Agreement. 
 d. The Company is entitled to rely upon this Subscription
Agreement and is irrevocably authorized to produce this Subscription Agreement or a copy hereof to any interested party in any administrative or legal proceeding or official inquiry with respect to the matters covered hereby. 

e. All the agreements, representations and warranties made by each party hereto in this Subscription Agreement shall survive
the Closing. 
 f. This Subscription Agreement may not be modified, waived or terminated except by an instrument in writing,
signed by the party against whom enforcement of such modification, waiver, or termination is sought. 
 g. This Subscription
Agreement constitutes the entire agreement, and supersedes all other prior agreements, understandings, representations and warranties, both written and oral, among the parties, with respect to the subject matter hereof. Except as otherwise expressly
set forth in subsection (c) of this Section 11, this Subscription Agreement shall not confer any rights or remedies upon any person other than the parties hereto, and their respective successor and assigns. 

h. Except as otherwise provided herein, this Subscription Agreement shall be binding upon, and inure to the benefit of the
parties hereto and their heirs, executors, administrators, successors, legal representatives, and permitted assigns, and the agreements, representations, warranties, covenants and acknowledgments contained herein shall be deemed to be made by, and
be binding upon, such heirs, executors, administrators, successors, legal representatives and permitted assigns. 
 i. If any
provision of this Subscription Agreement shall be invalid, illegal or unenforceable, the validity, legality or enforceability of the remaining provisions of this Agreement shall not in any way be affected or impaired thereby and shall continue in
full force and effect. 
 j. This Subscription Agreement may be executed in one or more counterparts (including by facsimile
or electronic mail or in .pdf) and by different parties in separate counterparts, with the same effect as if all parties hereto had signed the same document. All counterparts so executed and delivered shall be construed together and shall constitute
one and the same agreement. 
 k. The parties hereto agree that irreparable damage would occur in the event that any of the
provisions of this Subscription Agreement were not performed in accordance with their specific terms or were otherwise breached. It is accordingly agreed that the parties shall be entitled to an injunction or injunctions to prevent breaches of this
Subscription Agreement and to enforce specifically the terms and provisions of this Subscription Agreement, this being in addition to any other remedy to which such party is entitled at law, in equity, in contract, in tort or otherwise. 

l. The obligations of the undersigned under this Subscription Agreement are several and not joint with the obligations of any
Other Purchaser under any other subscription agreement. The undersigned shall be entitled independently to protect and enforce its rights, including its rights arising under this Subscription Agreement, and it shall not be necessary for any Other
Purchaser to be joined as an additional party in any proceeding for such purpose. Nothing contained in this Subscription Agreement or any subscription agreement entered into by any Other Purchaser, and no action taken by the undersigned pursuant
hereto or any Other Purchaser pursuant thereto, shall be deemed to constitute the undersigned and any Other Purchaser(s) as a partnership, an association, a joint venture or any other kind of entity, or create a presumption that the undersigned

  
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and any Other Purchaser(s) are acting as a group with respect to the transactions contemplated hereby or thereby. 

m. THIS SUBSCRIPTION AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF THE STATE OF NEW YORK,
WITHOUT REGARD TO THE PRINCIPLES OF CONFLICTS OF LAWS THAT WOULD OTHERWISE REQUIRE THE APPLICATION OF THE LAW OF ANY OTHER STATE. EACH PARTY HERETO HEREBY WAIVES ANY RIGHT TO A JURY TRIAL IN CONNECTION WITH ANY LITIGATION PURSUANT TO THIS
SUBSCRIPTION AGREEMENT AND THE TRANSACTIONS CONTEMPLATED HEREBY. 
 [SIGNATURE PAGES FOLLOW] 

  
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 IN WITNESS WHEREOF, the undersigned has executed or caused this Subscription
Agreement to be executed by its duly authorized representative as of the date set forth below. 
  

			
	 Name of Investor:
	  	 State/Country of Formation or Domicile:

		
	 RTW MASTER FUND, LTD.
	  	 CAYMAN ISLANDS

	 and
	  	
	 RTW INNOVATION MASTER FUND, LTD.
	  	
		
	 By: /s/ Roderick Wong,
M.D.                          
	  	
	 Name: Roderick Wong, M.D.
	  	
	 Title: Director
	  	

 Date: May 21, 2019 
  

			
	 Number of Shares:
	  	2,000,000 (subject to adjustment for any reverse split or other adjustment that may be effected for the purpose of meeting the initial listing requirements of the Nasdaq Capital Market)
		
	 Aggregate Subscription Amount: $6,500,000.00
	  	Price Per Share: $3.25 (subject to adjustment for any reverse split or other adjustment that may be effected for the purpose of meeting the initial listing requirements of the Nasdaq Capital Market)

 You must pay the Subscription Amount by wire transfer of United States dollars in immediately
available funds to the account specified by the Company in the Closing Notice. To the extent the offering is oversubscribed, the number of Shares received may be less than the number of Shares subscribed for, in which case the excess payment
representing the undersigned’s unfulfilled number of Shares shall be promptly returned to the undersigned in accordance with Section 1 of this Agreement. 

  
 10 

 IN WITNESS WHEREOF, the Company has accepted this Subscription
Agreement as of the date set forth below. 
  

			
	 CONSTELLATION ALPHA CAPITAL CORP.

		
	 By:
	 	 /s/ Rajiv Shukla

	 Name:
	 	 Rajiv Shukla

	 Title:
	 	 Chairman & CEO

 Date: May 23, 2019 

  
 11 

 SCHEDULE A 

ELIGIBILITY REPRESENTATIONS OF THE INVESTOR 
  

									
	 A.
	 	 QUALIFIED INSTITUTIONAL BUYER STATUS

(Please check the applicable subparagraphs):

				
		 	 1.
	 	 ☐
	 	 We are a “qualified institutional buyer” (as defined in Rule 144A under the Securities
Act).

		
	 B.
	 	 INSTITUTIONAL ACCREDITED INVESTOR STATUS

(Please check the applicable subparagraphs):

				
		 	 1.
	 	 ☒
	 	 We are an “accredited investor” (within the meaning of Rule 501(a) under the Securities Act. for one
or more of the following reasons (Please check the applicable subparagraphs):

					
		 		 		 	 ☐
	  	 We are a bank, as defined in Section 3(a)(2) of the Securities Act or any savings and loan association or other institution
as defined in Section 3(a)(5)(A) of the Securities Act, whether acting in an individual or a fiduciary capacity.

					
		 		 		 	 ☐
	  	 We are a broker or dealer registered under Section 15 of the Securities Exchange Act of 1934, as amended.

					
		 		 		 	 ☐
	  	 We are an insurance company, as defined in Section 2(13) of the Securities Act.

					
		 		 		 	 ☐
	  	 We are an investment company registered under the Investment Company Act of 1940 or a business development company, as
defined in Section 2(a)(48) of that act.

					
		 		 		 	 ☐
	  	 We are a Small Business Investment Company licensed by the U.S. Small Business Administration under Section 301(c) or (d)
of the Small Business Investment Act of 1958.

					
		 		 		 	 ☐
	  	 We are a plan established and maintained by a state, its political subdivisions or any agency or instrumentality of a state
or its political subdivisions for the benefit of its employees, if the plan has total assets in excess of $5 million.

					
		 		 		 	 ☐
	  	 We are an employee benefit plan within the meaning of Title I of the Employee Retirement Income Security Act of 1974, if
the investment decision is being made by a plan fiduciary, as defined in Section 3(21) of such act, and the plan fiduciary is either a bank, an insurance company, or a registered investment adviser, or if the employee benefit plan has total assets
in excess of $5 million.

					
		 		 		 	 ☐
	  	 We are a private business development company, as defined in Section 202(a)(22) of the Investment Advisers Act of
1940.

					
		 		 		 	 ☐
	  	 We are a corporation, Massachusetts or similar business trust, or partnership, or an organization described in Section
501(c)(3) of the Internal Revenue Code of 1986, as amended, that was not formed for the

  
 Schedule A 

									
		 		 		 		  	 specific purpose of acquiring the Securities, and that has total assets in excess of $5 million.

					
		 		 		 	 ☐
	  	 We are a trust with total assets in excess of $5 million not formed for the specific purpose of acquiring the
Securities, whose purchase is directed by a sophisticated person as described in Rule 506(b)(2)(ii) under the Securities Act.

					
		 		 		 	 ☒
	  	 We are an entity in which all of the equity owners are accredited investors.

		
	 B.
	 	 AFFILIATE STATUS

		
		 	 (Please check the applicable box)

 
 THE INVESTOR:

			
		 	 ☐
	 	 is:

			
		 	 ☒
	 	 is not:

			
		 		 	 an “affiliate” (as defined in Rule 144 under the Securities Act) of the Company or acting on behalf
of an affiliate of the Company.

		
		 	This page should be completed by the Investor and constitutes a part of the Subscription Agreement

  
 Schedule A 

 SCHEDULE B 

ELIGIBILITY REPRESENTATIONS OF THE INVESTOR (Canadian Investors Only) 

 

	 	1.	 We hereby declare, represent and warrant that: 

 

	(a)	 we are purchasing the Shares as principal for our own account, or are deemed to be purchasing the Shares as
principal for our own account in accordance with applicable Canadian securities laws, and not as agent for the benefit of another investor; 

  

	(b)	 we are residents in or subject to the laws of one of the provinces or territories of Canada;

  

	(c)	 we are entitled under applicable securities laws to purchase the Shares without the benefit of a prospectus
qualified under such securities laws and, without limiting the generality of the foregoing, are both: 

  

	 	a.	 an “accredited investor” as defined in section 1.1 of National Instrument 45-106 Prospectus Exemptions (“NI 45-106”) or section 73.3(2) of the Securities Act (Ontario) by virtue of satisfying the indicated criterion in
Section 11 below, and we are not a person created or used solely to purchase or hold securities as an “accredited investor” as described in paragraph (m) of the definition of “accredited investor” in section 1.1 of NI 45-106; and 

  

	 	b.	 a “permitted client” as defined in section 1.1 of National Instrument 31-103 Registration Requirements, Exemptions and Ongoing Registrant Obligations (“NI 31-103”) by virtue of satisfying the indicated criterion in
Section 12 below 

  

	(d)	 we have received, reviewed and understood, this Subscription Agreement and certain disclosure materials
(the “Canadian Disclosure Package”) relating to the placing of Shares in Canada and, are basing our investment decision solely on this Subscription and the Canadian Disclosure Package and not on any other information concerning the
Company or the offering of the Shares; 

  

	(e)	 the acquisition of Shares does not and will not contravene any applicable Canadian securities laws, rules or
policies of the jurisdiction in which we are resident and does not trigger (i) any obligation to prepare and file a prospectus or similar document or (ii) any registration or other similar obligation on the part of any person;

  

	(f)	 we will execute and deliver within the applicable time periods all documentation as may be required by
applicable Canadian securities laws to permit the purchase of the Shares on the terms set forth herein and, if required by applicable Canadian securities laws, will execute, deliver and file or assist the Company in obtaining and filing such
reports, undertakings and other documents relating to the purchase of the Shares as may be required by any applicable Canadian securities laws, securities regulator, stock exchange or other regulatory authority; and 

 

	(g)	 neither we nor any party on whose behalf we are acting has been established, formed or incorporated solely
to acquire or permit the purchase of Shares without a prospectus in reliance on an exemption from the prospectus requirements of applicable Canadian securities laws. 

 

	 	2.	 We are aware of the characteristics of the Shares, the risks relating to an investment therein and agree
that we must bear the economic risk of its investment in the Shares. We understand that we will not be able to resell the Shares under applicable Canadian securities laws except in accordance with limited exemptions 

  
 Schedule B 

 and compliance with other requirements of applicable law, and we (and not the Company) are
responsible for compliance with applicable resale restrictions or hold periods and will comply with all relevant Canadian securities laws in connection with any resale of the Shares. 

 

	 	3.	 We hereby undertake to notify the Company immediately of any change to any declaration, representation,
warranty or other information relating to us set forth herein which takes place prior to the closing of the purchase of the Shares applied for hereby. 

  

	 	4.	 We understand and acknowledge that (i) the Company is not a reporting issuer in any province or
territory in Canada and its securities are not listed on any stock exchange in Canada and there is currently no public market for the Shares in Canada; and (ii) the Company currently has no intention of becoming a reporting issuer in Canada and
the Company is not obligated to file and has no present intention of filing a prospectus with any securities regulatory authority in Canada to qualify the resale of the Shares to the public, or listing the Company’s securities on any stock
exchange in Canada and thus the applicable restricted period or hold period may not commence and the Shares may be subject to an unlimited hold period or restricted period in Canada and in that case may only be sold pursuant to limited exemptions
under applicable securities legislation. 

  

	 	5.	 We confirm we have reviewed the terms referred to under the heading “Resale Restrictions” in the
Canadian Disclosure Package. 

  

	 	6.	 It is acknowledged that we should consult our own legal and tax advisors with respect to the tax
consequences of an investment in the Shares in our particular circumstances and with respect to the eligibility of the Shares for investment by us and resale restrictions under relevant Canadian legislation and regulations, and that we have not
relied on the Company or on the contents of the Canadian Disclosure Package, for any legal, tax or financial advice. 

  

	 	7.	 If we are a resident of Quebec, we acknowledge that it is our express wish that all documents evidencing or
relating in any way to the sale of the Shares be drawn in the English language only. Si nous sommes résidents de la province de Québec, nous reconnaissons par les présentes que c’est notre volonté expresse que
tous les documents faisant foi ou se rapportant de quelque manière à la vente des engagements soient rédigés en anglais seulement. 

 

	 	8.	 We understand and acknowledge that we are making the representations, warranties and agreements contained
herein with the intent that they may be relied upon by the Company and the agents in determining our eligibility to purchase the Shares, including the availability of exemptions from the prospectus requirements of applicable Canadian securities laws
in connection with the issuance of the Shares. 

  

	 	9.	 We consent to the collection, use and disclosure of certain personal information for the purposes of meeting
legal, regulatory, self-regulatory, security and audit requirements (including any applicable tax, securities, money laundering or anti-terrorism legislation, rules or regulations) and as otherwise permitted or required by law, which disclosures may
include disclosures to tax, securities or other regulatory or self-regulatory authorities in Canada and/or in foreign jurisdictions, if applicable, in connection with the regulatory oversight mandate of such authorities. 

 

	 	10.	 If we are an individual resident in Canada, we acknowledge that: (A) the Company or the agents may be
required to provide personal information pertaining to us as required to be 

  
 Schedule B 

	 	 
disclosed in Schedule I of Form 45-106F1 Report of Exempt Distribution (“Form 45-106F1”) under NI 45-106 (including its name, email address, address, telephone number and the aggregate purchase price paid by the purchaser) (“personal 

  
 Schedule B 

 information”) to the securities regulatory authority or regulator in the local
jurisdiction (the “Regulator”); (B) the personal information is being collected indirectly by the Regulator under the authority granted to it in securities legislation; and (C) the personal information is being collected for the
purposes of the administration and enforcement of the securities legislation; and by purchasing the securities, we shall be deemed to have authorized such indirect collection of personal information by the Regulator. Questions about the indirect
collection of information should be directed to the Regulator in the local jurisdiction, using the contact information set out below: 
  

	(a)	 in Alberta, the Alberta Securities Commission, Suite 600, 250 - 5th Street SW, Calgary, Alberta T2P 0R4,
Telephone: (403) 297-6454, toll free in Canada: 1-877-355-0585; 

 

	(b)	 in British Columbia, the British Columbia Securities Commission, P.O. Box 10142, Pacific Centre, 701 West
Georgia Street, Vancouver, British Columbia V7Y 1L2, Inquiries: (604) 899- 6581, toll free in Canada:
1-800-373-6393, Email: inquiries@bcsc.bc.ca; 

 

	(c)	 in Manitoba, The Manitoba Securities Commission, 500 - 400 St. Mary Avenue, Winnipeg, Manitoba R3C 4K5,
Telephone: (204) 945-2548, toll free in Manitoba 1-800-655-5244; 

 

	(d)	 in New Brunswick, Financial and Consumer Services Commission (New Brunswick), 85 Charlotte Street, Suite
300, Saint John, New Brunswick E2L 2J2, Telephone: (506) 658-3060, toll free in Canada:
1-866-933-2222, Email: info@fcnb.ca; 

  

	(e)	 in Newfoundland and Labrador, Government of Newfoundland and Labrador, Financial Services Regulation
Division, P.O. Box 8700, Confederation Building, 2nd Floor, West Block, Prince Philip Drive, St. John’s, Newfoundland and Labrador, A1B 4J6, Attention: Director of Securities, Telephone: (709) 729-4189,

  

	(f)	 in the Northwest Territories, the Government of the Northwest Territories, Office of the Superintendent of
Securities, P.O. Box 1320, Yellowknife, Northwest Territories X1A 2L9, Attention: Deputy Superintendent, Legal & Enforcement, Telephone: (867) 920-8984; 

 

	(g)	 in Nova Scotia, the Nova Scotia Securities Commission, Suite 400, 5251 Duke Street, Duke Tower, P.O. Box
458, Halifax, Nova Scotia B3J 2P8, Telephone: (902) 424-7768; 

  

	(h)	 in Nunavut, Government of Nunavut, Department of Justice, Legal Registries Division, P.O. Box 1000, Station
570, 1st Floor, Brown Building, Iqaluit, Nunavut X0A 0H0, Telephone: (867) 975- 6590; 

  

	(i)	 in Ontario, the Inquiries Officer at the Ontario Securities Commission, 20 Queen Street West, 22nd Floor,
Toronto, Ontario M5H 3S8, Telephone: (416) 593-8314, toll free in Canada: 1-877-
785-1555, Email: exemptmarketfilings@osc.gov.on.ca; 

  

	(j)	 in Prince Edward Island, the Prince Edward Island Securities Office, 95 Rochford Street, 4th Floor Shaw
Building, P.O. Box 2000, Charlottetown, Prince Edward Island C1A 7N8, Telephone: (902) 368-4569; 

  

	(k)	 in Québec, the Autorité des marchés financiers, 800, Square Victoria, 22e étage,
C.P. 246, Tour de la Bourse, Montréal, Québec H4Z 1G3, Telephone: (514) 395-0337 or
1-877-525-0337, Email: financementdessocietes@lautorite.qc.ca (For corporate finance issuers),
fonds_dinvestissement@lautorite.qc.ca (For investment fund issuers); 

  
 Schedule B 

	(l)	 in Saskatchewan, the Financial and Consumer Affairs Authority of Saskatchewan, Suite 601 - 1919 Saskatchewan
Drive, Regina, Saskatchewan S4P 4H2, Telephone: (306) 787-5879; and 

  

	(m)	 in Yukon, Government of Yukon, Department of Community Services, Law Centre, 3rd Floor, 2130 Second Avenue,
Whitehorse, Yukon Y1A 5H6, Telephone: (867) 667-5314. 

  

	 	11.	 We hereby represent, warrant, covenant and certify that we are, or any party on whose behalf we are acting
is, an “accredited investor” as defined in NI 45-106 or section 73.3(1) of the Securities Act (Ontario) by virtue of satisfying the indicated criterion below: 

Please check the category that applies: 
  

					
	 ☐
	  		  	 a Canadian financial institution or a Schedule III bank of the Bank Act (Canada),

			
	 ☐
	  		  	 the Business Development Bank of Canada incorporated under the Business Development Bank of Canada Act
(Canada),

			
	 ☐
	  		  	 a subsidiary of any person or company referred to in paragraphs (a) or (b) if the person or company owns all of the
voting securities of the subsidiary, except the voting securities required by law to be owned by directors of that subsidiary,

			
	 ☐
	  		  	 a person or company registered under the securities legislation of a province or territory of Canada as an adviser or
dealer, except as otherwise prescribed by the regulations,

			
		  		  	 [omitted]

			
		  	(e.1)	  	 [omitted]

			
	 ☐
	  		  	 the Government of Canada, the government of a province or territory of Canada, or any Crown corporation, agency or wholly
owned entity of the Government of Canada or of the government of a province or territory of Canada,

			
	 ☐
	  		  	 a municipality, public board or commission in Canada and a metropolitan community, school board, the Comité de
gestion de la taxe scolaire de l’île de Montréal or an intermunicipal management board in Québec,

			
	 ☐
	  		  	 any national, federal, state, provincial, territorial or municipal government of or in any foreign jurisdiction, or any
agency of that government,

			
	 ☐
	  	(i)	  	 a pension fund that is regulated by either the Office of the Superintendent of Financial Institutions (Canada) or a pension
commission or similar regulatory authority of a province or territory of Canada,

			
		  		  	 [omitted]

			
	 ☐
	  	(j.1)	  	 an individual who beneficially owns financial assets having an aggregate realizable value that before taxes, but net of any
related liabilities, exceeds CAD$5,000,000,

			
		  		  	 [omitted]

			
		  		  	 [omitted]

			
	 ☐
	  		  	 a person, other than an individual or investment fund, that has net assets of at least $5,000,000 as shown on its most
recently prepared financial statements,

			
	 ☐
	  		  	 an investment fund that distributes or has distributed its securities only to

			
		  		  	 a person that is or was an accredited investor at the time of the distribution,

  
 Schedule B 

							
		  		  	 a person that acquires or acquired securities in the circumstances referred to in sections 2.10 of NI 45-106 [Minimum amount investment], or 2.19 of NI 45-106 [Additional investment in investment funds], or

 
 a person described in paragraph (i) or (ii) that
acquires or acquired securities under section 2.18 of NI 45-106 [Investment fund reinvestment],

			
	 ☐
	  		  	 an investment fund that distributes or has distributed securities under a prospectus in a jurisdiction of
Canada for which the regulator or, in Québec, the securities regulatory authority, has issued a receipt,

			
	 ☐
	  		  	 a trust company or trust corporation registered or authorized to carry on business under the Trust and Loan
Companies Act (Canada) or under comparable legislation in a jurisdiction of Canada or a foreign jurisdiction, acting on behalf of a fully managed account managed by the trust company or trust corporation, as the case may be,

			
	 ☐
	  		  	 a person acting on behalf of a fully managed account1
managed by that person, if that person is registered or authorized to carry on business as an adviser or the equivalent under the securities legislation of a jurisdiction of Canada or a foreign jurisdiction,

			
	 ☐
	  		  	 a registered charity under the Income Tax Act (Canada) that, in regard to the trade, has obtained advice
from an eligibility adviser or an adviser registered under the securities legislation of the jurisdiction of the registered charity to give advice on the securities being traded,

			
	 ☐
	  		  	 an entity organized in a foreign jurisdiction that is analogous to any of the entities referred to in
paragraphs (a) through (d) or paragraph (i) in form and function,

			
	 ☐
	  		  	 a person in respect of which all of the owners of interests, direct, indirect or beneficial, except the voting
securities required by law to be owned by directors, are persons that are accredited investors,

			
	 ☐
	  		  	 an investment fund that is advised by a person registered as an adviser or a person that is exempt from
registration as an adviser,

			
	 ☐
	  		  	 a person that is recognized or designated by the Commission as an accredited investor,

			
	 ☐
	  		  	 a trust established by an accredited investor for the benefit of the accredited investor’s family members
of which a majority of the trustees are accredited investors and all of the beneficiaries are the accredited investor’s spouse, a former spouse of the accredited investor or a parent, grandparent, brother, sister, child or grandchild of that
accredited investor, of that accredited investor’s spouse or of that accredited investor’s former spouse.

				
		  		  	 12.
	  	 We hereby represent, warrant, covenant and certify that we are, or any party on whose behalf we are acting is, a
“permitted client” by virtue of the criterion indicated below,

		
		  	Please check the category that applies:
				
		  	 ☐
	  	 (a)
	  	 a Canadian financial institution or a Schedule III bank;

				
		  	 ☐
	  	 (b)
	  	 the Business Development Bank of Canada incorporated under the Business Development Bank of Canada Act
(Canada);

				
		  	 ☐
	  	 (c)
	  	 a subsidiary of any person or company referred to in paragraph (a) or (b), if the person or company owns all of the
voting securities of the subsidiary, except the voting securities

  

	1 	 A “fully managed account” means an account of a client for which a person makes the
investment decisions if that person has full discretion to trade in securities for the account without requiring the client’s express consent to a transaction. 

  
 Schedule B 

					
		  		  	 required by law to be owned by directors of the subsidiary;

			
		  	 ☐
	  	 (d)   a person or company registered under the securities
legislation of a jurisdiction of Canada as an adviser, investment dealer, mutual fund dealer or exempt market dealer;

			
		  	 ☐
	  	 (e)   a pension fund that is regulated by either the Office of
the Superintendent of Financial Institutions or a pension commission or similar regulatory authority of a jurisdiction of Canada or a wholly-owned subsidiary of such a pension fund;

			
		  	 ☐
	  	 (f)   an entity organized in a foreign jurisdiction that is
analogous to any of the entities referred to in paragraphs (a) through (e);

			
		  	 ☐
	  	 (g)   the Government of Canada or a jurisdiction of Canada, or
any Crown corporation, agency or wholly-owned entity of the Government of Canada or a jurisdiction of Canada;

			
		  	 ☐
	  	 (h)   any national, federal, state, provincial, territorial or
municipal government of or in any foreign jurisdiction, or any agency of that government;

			
		  	 ☐
	  	 (i) a municipality, public board or commission in Canada and a metropolitan
community, school board, the Comité de gestion de la taxe scolaire de l’île de Montréal or an intermunicipal management board in Quebec;

			
		  	 ☐
	  	 (j) a trust company or trust corporation registered or authorized to carry
on business under the Trust and Loan Companies Act (Canada) or under comparable legislation in a jurisdiction of Canada or a foreign jurisdiction, acting on behalf of a managed account managed by the trust company or trust corporation, as the case
may be;

			
		  	 ☐
	  	 (k)   a person or company acting on behalf of a managed account
managed by person or company, if the person or company is registered or authorized to carry on business as an adviser or the equivalent under the securities legislation of a jurisdiction of Canada or a foreign jurisdiction;

			
		  	 ☐
	  	 (l) an investment fund if one or both of the following apply:

			
		  		  	 (i) the fund is managed by a person or company registered as an investment fund manager under the
securities legislation of a jurisdiction of Canada;

			
		  		  	 (ii) the fund is advised by a person or company authorized to act as an adviser under the securities
legislation of a jurisdiction of Canada;

			
		  	 ☐
	  	 (m) in respect of a dealer, a registered charity under the Income Tax Act
(Canada) that obtains advice on the securities to be traded from an eligibility adviser or an adviser registered under the securities legislation of the jurisdiction of the registered charity;

			
		  	 ☐
	  	 (n)   in respect of an adviser, a registered charity under the
Income Tax Act (Canada) that is advised by an eligibility adviser or an adviser registered under the securities legislation of the jurisdiction of the registered charity;

			
		  	 ☐
	  	 (o)   a registered charity under the Income Tax Act (Canada)
that obtains advice on the securities to be traded from an eligibility adviser or an adviser registered under the securities legislation of the jurisdiction of the registered charity;

			
		  	 ☐
	  	 (p)   an individual who beneficially owns financial assets
having an aggregate realizable value that, before taxes but net of any related liabilities, exceeds $5 million;

			
		  	 ☐
	  	 (q)   a person or company that is entirely owned by an
individual or individuals referred to in paragraph (o), who holds the beneficial ownership interest in the person or company directly or through a trust, the trustee of which is a trust company or trust
corporation

  
 Schedule B 

					
		  		  	 registered or authorized to carry on business under the Trust and Loan Companies Act (Canada) or
under comparable legislation in a jurisdiction of Canada or a foreign jurisdiction;

			
		  	 ☐
	  	 (r)   a person or company, other than an individual or an
investment fund, that has net assets of at least C$25,000,000 as shown on its most recently prepared financial statements; or

			
		  	 ☐
	  	 (s)   a person or company that distributes securities of its own
issue in Canada only to persons or companies referred to in paragraphs (a) through (r).

  
 Schedule B 

 SCHEDULE C 

DISCLOSURE PACKAGE 
 (SEE
ATTACHED) 

  
 Schedule C 

 SCHEDULE D 

MATERIAL TERMS OF TRANSACTION 
  

	1.	 The Company has no shares of preferred stock issued and outstanding. After giving effect to the Transaction
and the subscription of Company Shares by the undersigned and the Other Purchasers, the Company has (i) no less than 25,754,267 Company Shares outstanding and (ii) no more than 26,295,003 Company Shares outstanding. 

 

	2.	 After giving effect to the subscription of Company Shares by the undersigned and the Other Purchasers, the
Company has an aggregate of at least $15,000,000 of non-redeemable cash. 

  

	3.	 The Company Shares continue to be listed on Nasdaq Capital Market. 

 

	4.	 The Company has not issued or sold any Company stock for less than $3.25 per share (which share price may be
adjusted as described in number 7 below). 

  

	5.	 The Company has not received aggregate gross proceeds of more than $20 million from the sale of Company
stock since the date of the Transaction Agreement. 

  

	6.	 The Company has not purchased or redeemed any Company stock, except pursuant to any redemption rights
currently provided for in amended and restated articles of association of the Company. 

  

	7.	 The Company has not effected any stock split, stock dividend, extraordinary cash dividend, recapitalization
or other like with respect to Company stock, other than any reverse split or other adjustment that may be effected for the purpose of meeting the initial listing requirements of the Nasdaq Capital Market. 

 

	8.	 The shareholders of DermTech, Inc. shall not receive more than 16,000,000 Company Shares in the Transaction
less total number of Company Shares that can be acquired or received pursuant to “in-the-money” options, restricted stock units and warrants of DermTech, Inc.

  
 Schedule D 

 SCHEDULE E 

PROMISSORY NOTES 
  

					
	 Holder
	  	Amount	 
	 Rajiv S. Shukla
	  	$	25,000	 
	 Cowen Investments II LLC
	  	$	55,000	 

  
 Schedule EEX-10.41

 Exhibit 10.41 

CONVERTIBLE PROMISSORY NOTE 

THIS NOTE AND THE SHARES OF CAPITAL STOCK ISSUED UPON ANY CONVERSION HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS
AMENDED (THE “SECURITIES ACT”), OR ANY APPLICABLE STATE SECURITIES LAWS AND MAY NOT BE SOLD OR OTHERWISE TRANSFERRED BY ANY PERSON, INCLUDING A PLEDGEE, UNLESS (1) EITHER (A) A REGISTRATION WITH RESPECT THERETO SHALL BE
EFFECTIVE UNDER THE SECURITIES ACT, OR (B) THE COMPANY SHALL HAVE RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY THAT AN EXEMPTION FROM REGISTRATION UNDER THE SECURITIES ACT IS AVAILABLE, AND (2) THERE SHALL HAVE BEEN
COMPLIANCE WITH ALL APPLICABLE STATE SECURITIES OR “BLUE SKY” LAWS. 
 DERMTECH, INC. 

CONVERTIBLE PROMISSORY NOTE 
  

			
	 US$1,362,507.00
	  	August 17, 2018        

 DermTech, Inc., a corporation duly formed under the laws of the State of Delaware, (the
“Company”), for value received, hereby promises to pay to RTW Master Fund, Ltd. or registered assigns (the “Note Holder”) the principal sum of US$1,362,507.00, together with interest, in the manner provided herein.

 1. Maturity Date; Repayment. 

(a) Maturity Date. Unless converted as provided in Section 3 herein, all amounts outstanding and unpaid under this
Convertible Promissory Note (this “Note”) shall be due and payable on or at any time (such time a “Maturity Event”) after the earliest to occur of: (i) March 31, 2019 (the “Maturity
Date”), (ii) the occurrence of an Event of Default (as defined in Section 5 hereof), (iii) the consummation of a liquidation or dissolution of the Company (each, a “Liquidation Event”), or (iv) a
Liquidation Transaction as defined in the Company’s Amended and Restated Certificate of Incorporation. At any time thereafter, the Note Holder may make written demand to the Company for repayment; provided, however, that no written demand shall
be required for repayment pursuant to a Liquidation Event. 
 (b) Repayment. On or after the Maturity Date, the
Company may elect to repay all (but not any parts of) amounts outstanding and unpaid under this Note so long as the Company has provided ten (10) business days written notice to the Note Holder of its intention to repay this Note. Any payments
shall be made pro rata amount among all holders of Notes (as defined below). 
 2. Interest. Interest on the unpaid principal
amount shall accrue beginning on the issue date set forth above at a rate equal to ten percent (10%) per annum, computed on the basis of the actual number of days elapsed and a year of 365 days from the date of this Note until the principal amount
and all interest accrued thereon are paid or converted, as provided in Section 3 hereof; provided that, for each day that this Note remains due and payable following the occurrence of a Maturity Event , interest on the unpaid principal
amount shall accrue at a rate equal to fifteen (15%) per annum. Except on earlier conversion in accordance with Section 3, interest shall not be due and payable until the Maturity Date or an earlier Event of Default or Liquidation Event. 

 3. Conversion, Registration Rights, Right of First Offer and Future
Rights. 
 (a) Automatic Conversion in Connection with a Qualified Financing. The unpaid principal amount of this
Note together with any interest accrued but unpaid thereon, shall automatically be converted into shares of the Company’s equity securities to be issued and sold at the closing of a single or series of related capital raising transactions in
which the Company issues equity securities to persons or entities in which the aggregate gross proceeds to the Company are at least twenty million Dollars ($20,000,000) (“Qualified Financing”) (including proceeds up to $3,000,000
received by the Company from this Note and any other Note of substantially the same form issued on or after the date hereof and prior to such Qualified Financing (collectively, the “Notes”)) that occurs on or prior to the Maturity
Date (it being understood that if such Qualified Financing consists of more than one type of security, the Note Holder shall be entitled to receive all of such securities upon such conversion). Upon the conversion of this Note pursuant to this
Section 3(a), the Note Holder shall be entitled to receive (I) a number of shares of the Company’s equity securities to be issued and sold at the closing of the next Qualified Financing (“New Stock”) to be issued upon
such conversion equal to the quotient obtained by dividing the unpaid principal amount of this Note plus interest accrued but unpaid thereon, by the lesser of (i) the lowest price per share of the New Stock paid in the Qualified Financing by
investors multiplied by (x) if such Qualified Financing occurs on or prior to November 15, 2018, 90%, and (y) if such Qualified Financing occurs after November 15, 2018, 80%, and (ii) the price per share obtained by dividing
$45,000,000 by the Company’s fully-diluted capitalization immediately prior to such Qualified Financing assuming exercise or conversion of all outstanding options and issuance of all outstanding restricted stock unit awards, including all
shares of Common Stock reserved and available for future grant under any equity incentive or similar plan of the Company, and/or any equity incentive or similar plan to be created or increased in connection with the Qualified Financing, but
excluding any shares issuable upon exercise of the Company’s outstanding warrants or conversion of the Notes; (II) to the extent that the Company issues warrants to the investors in the Qualified Financing, a warrant, in substantially the
same form as the warrants issued to the investors in the Qualified Financing (“New Warrant”), exercisable for a number of shares of the New Warrant’s underlying securities equal to the number of shares of such underlying
securities that the New Warrant would have been exercisable for if the Note Holder purchased a number of shares of the Company’s equity securities in such financing equal to the amount of New Stock that the Note Holder would be entitled to
under Section 3(a)(I) in connection with such Qualified Financing; and (III) to the extent that the Company issues any other type of non-equity securities to the investors in the Qualified Financing,
non-equity securities in substantially the same form as the non-equity securities issued to the investors in the Qualified Financing (“New Non-Equity Securities”) in an amount based upon the calculation provided in the foregoing Section 3(a)(II), with such calculation adjusted only as necessary to account for differences between the
mechanics of a warrant and the mechanics of the New Non-Equity Securities. The issuance of the shares of New Stock, the New Warrant and the New Non-Equity Securities
upon such conversion shall be upon the terms and subject to the conditions applicable to the Qualified Financing. Upon such conversion, the Note Holder will execute such agreements as may be entered into by purchasers of shares of New Stock
in the Qualified Financing generally, if any. The Company shall use best efforts to ensure that the Note Holder, together with RTW Innovation Master Fund, Ltd., continues to have the right to designate a member to the Company’s board of
directors pursuant to that certain Amended and Restated Voting Agreement, dated as of September 26, 2017 and amended on March 5, 2018, by and among the Company, the Note Holder and other parties thereto, following the closing of the
Qualified Financing. 
 (b) Optional Conversion. At any time, the Note Holder may elect, at any time, upon two
(2) business days written notice to the Company, to convert all, but not less than all, of the outstanding principal balance under this Note, together with any accrued but unpaid interest thereon, into shares of the Company’s Series C
Preferred Stock (the “Optional Conversion”). Upon conversion of this Note pursuant to this Section 3(b), the Note Holder shall be entitled to receive (1) a number of shares of the Company’s Series C Preferred Stock
equal to the quotient obtained by dividing (i) the unpaid principal amount of this Note plus interest accrued but unpaid thereon, by (ii) $5.54, subject to equitable adjustment whenever there shall occur a stock dividend, stock
split, combination, reclassification or other similar event (the “Optional Conversion Calculation”) and (2) warrants, in substantially the same form as any warrants issued to any purchasers of the Company’s Series C
Preferred Stock. 
 (c) Change in Control. The Company shall provide the Note Holder with ten (10) business days
prior written notice before Company consummates a Change of Control (as hereinafter defined) prior to the payment in full or conversion of this Note, and such notice shall include the material terms and conditions of such Change of Control along
with any term sheets, letters of intent, or other definitive agreements. If the Company consummates a Change of Control (as hereinafter defined) prior to the payment in full or conversion of this Note, then the Note Holder may

  
 2 

 
elect, upon two (2) business days written notice to the Company, to either (1) effect an Optional Conversion in accordance with the Optional Conversion Calculation; or (2) demand
payment of the then outstanding principal amount and the then current accrued but unpaid interest under this Note (the “Base Amount”) plus an amount equal to the Base Amount multiplied by, (i) if such Change of Control is
consummated on or prior to March 31, 2019, 150%, or (ii) if such Change of Control is consummated after March 31, 2019, 175%. A “Change of Control” shall mean the occurrence of (i) any transaction or series of
related transactions that results in a “person” or “group” (within the meaning of Section 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended), becoming the “beneficial owner” (as defined in Rule 13d-3 under the Securities Exchange Act of 1934, as amended), directly or indirectly, of more than fifty percent (50%) of the outstanding voting securities of the Company having the right to vote for the election of
members of the Board of Directors of the Company, (ii) any reorganization, merger or consolidation of the Company, other than a transaction or series of related transactions in which the holders of the voting securities of the Company
outstanding immediately prior to such transaction or series of related transactions retain, immediately after such transaction or series of related transactions, at least a majority of the total voting power represented by the outstanding voting
securities of the Company or such other surviving or resulting entity, or (iii) a sale, lease or other disposition of all or substantially all of the assets of the Company. 

(d) Registration Rights. The holder of the securities issued upon conversion of this Note shall be entitled to the
registration rights provided in the Amended and Restated Investors’ Rights Agreement dated September 26, 2017, by and among the Company, the Note Holder and other parties thereto, as may be amended (the “A&R IRA”),
upon becoming a party to such agreement (if not already a party). 
 (e) Right of First Offer. The Note Holder shall
be entitled to the same right of first offer provided in Section 2.2 of the A&R IRA to Major Investors (as defined therein), notwithstanding the fact that the Note Holder may not be considered a Major Investor. For purposes of
Section 2.2 of the A&R IRA, the number of shares of the Company’s Common Stock issuable upon conversion and exercise of all convertible or exercisable securities then held by the Note Holder shall be calculated based solely upon the
holdings that that Note Holder would receive from this Note if it was converted in accordance with the terms of Section 3(b). 

(f) Optional Conversion at Non-Qualified Financing. In the event the Company
consummates, on or before the Maturity Date, an equity financing pursuant to which it sells shares of equity in a transaction that does not constitute a Qualified Financing, then the Company shall provide written notice to the Note Holder, and the
Note Holder shall have the option, but not the obligation, to elect to treat such equity financing as a Qualified Financing on the same terms set forth herein. 

(g) Future Rights. In the event that, prior to the Company’s payment in full of all obligations hereunder, the
Company issues any convertible debt (or similar securities), including any other Notes, which provides any rights, preferences, or privileges that are in any way different or more favorable than the rights, preferences and privileges set forth in
this Note, then the Company shall provide prompt written notice to the Note Holder, including details regarding any different or more favorable rights, preferences or privileges, and shall provide the Note Holder with the right to elect any of such
rights, preferences, or privileges with respect to this Note. 
 4. Mechanics of Conversion. 

(a) No Fractional Shares. No fractional shares will be issued upon conversion of this Note. In lieu of any fractional
share to which the Note Holder would otherwise be entitled, the Company will pay to the Note Holder in cash any amount that would otherwise be converted into such fractional share. 

(b) Automatic Conversion Mechanics. In the event that this Note is converted into New Stock (and to the extent
applicable, a New Warrant and/or New Non-Equity Securities) pursuant to Section 3(a), the Note Holder shall surrender this Note, duly endorsed, to the Company at the closing of the Qualified Financing and
this Note shall thereupon be canceled. As soon as practicable following surrender of this Note (or a duly executed affidavit of loss with any indemnity requested by the Company) and at its expense, the Company will issue and deliver to the Note
Holder, a certificate or certificates representing the number of shares of New Stock to which the Note Holder is entitled upon such conversion (and to the extent applicable, a warrant agreement representing the New Warrant to which the Note Holder
is entitled and/or customary documentation representing any New Non-Equity Securities to which the 

  
 3 

 
Note Holder is entitled), together with a check payable to the Note Holder for any cash amounts payable pursuant to Section 4(a). 

(c) Optional Conversion Mechanics. In the event that this Note is converted into Series C Preferred Stock
pursuant to Section 3(b), the Note Holder shall notify the Company at least two (2) calendar days prior to the date that the Note Holder intends to effect the Optional Conversion. The Company shall at all times during which this Note shall
be outstanding, reserve and keep available out of its authorized but unissued stock, for the purpose of effecting the conversion of this Note, (i) the requisite number of shares of Series C Preferred Stock for issuance upon conversion of
this Note prior to the issuance of such shares and (ii) sufficient shares of the Company’s Common Stock for issuance upon conversion of the Series C Preferred Stock. At the time of the consummation of the Optional Conversion,
the Note Holder shall surrender this Note, duly endorsed, to the Company and this Note shall thereupon be canceled. As soon as practicable following surrender of this Note (or a duly executed affidavit of loss with any indemnity requested by the
Company) and, at its expense, the Company will issue and deliver to the Note Holder a certificate or certificates representing the number of shares of Series C Preferred Stock to which the Note Holder is entitled upon the Optional Conversion,
together with a check payable to the Note Holder for any cash amounts payable pursuant to Section 4(a). 
 5.
Event of Default. If either of the following events (each, an “Event of Default”) shall occur and be continuing: 

(a) default in the payment when due of any principal or interest under this Note or default in the conversion of this Note in
accordance with the terms hereof, where such default shall continue uncured for a period of five (5) business days after written notice by the Note Holder; 

(b) the institution against the Company or any endorser or guarantor of this Note of any proceedings under the United States
Bankruptcy Code or any other federal or state bankruptcy, reorganization, receivership, insolvency or other similar law affecting the rights of creditors generally, which proceeding is not dismissed within sixty (60) calendar days of
filing; or the institution by the Company or any endorser or guarantor of this Note of any proceedings under the United States Bankruptcy Code or any other federal or state bankruptcy, reorganization, receivership, insolvency or other similar law
affecting the rights of creditors generally or the making by the Company or any endorser or guarantor of this Note of a composition or an assignment or trust mortgage for the benefit of creditors; 

(c) a material breach by the Company of any of its covenants, representations or warranties in this Note, provided that the
Note Holder notified the Company of the breach and the Company failed to cure or remedy within thirty (30) days of such notice; 

(d) the Company defaults under any Indebtedness (as hereinafter defined) of the Company which default results in the
acceleration of such Indebtedness prior to its express maturity and the principal amount of any such Indebtedness, together with the principal amount of any other such Indebtedness for borrowed money under which the maturity has been accelerated,
exceeds $500,000; or 
 (e) one or more judgments in an aggregate amount in excess of $500,000 (which are not covered by
insurance) are rendered against the Company and such judgments are not discharged, stayed or satisfied within 90 days after such judgments become final and non-appealable; 

    then, and in any such event, the Note Holder may, by notice to the Company, declare the entire
unpaid principal amount of this Note, all interest accrued and unpaid hereon and all other amounts payable under this Note to be forthwith due and payable. 

6. Liquidation Event. In the event that, prior to the prior to the payment in full or conversion of this Note,
the Company enters into a definitive agreement or plan to effect a Liquidation Event, the Company shall notify the Note Holder of such determination and the Note Holder shall be entitled to elect in writing to receive, upon consummation of such
Liquidation Event, an amount equal to (i) the then outstanding principal amount under this Note and (ii) the then current accrued but unpaid interest under this Note.  

7. Future Indebtedness. The Company shall not, without the written consent of the Note Holder, incur

  
 4 

 
any Indebtedness following the issuance of this Note, other than (i) Indebtedness pursuant to the Notes or (ii) Indebtedness that is junior in right of payment to the Notes, until all
of the principal and interest under the Notes has been paid in full or converted in accordance with the terms of the Notes. “Indebtedness” means obligations with respect to principal, accrued and unpaid interest, penalties, premiums
and any other fees, expenses and breakage costs on and other payment obligations arising under any (a) indebtedness for borrowed money, (b) indebtedness issued in exchange for or in substitution for borrowed money, (c) obligations
evidenced by any note, bond, debenture, guarantee or other debt security or similar instrument or contract and (e) guarantees of the types of obligations described in clauses (a) though (d) above. 

8. Termination of Rights. Upon payment in full of this Note in accordance with Section 1, conversion of this
Note in accordance with Section 3 or payment in full of this Note in connection with a Liquidation Event in accordance with Section 6, all rights with respect to this Note shall terminate, whether or not the Note has been surrendered for
cancellation, and the Company will be forever released from all of its obligations and liabilities under this Note except its obligations pursuant to Sections 3, 4, 6 and 16. 

9. Representations and Warranties of the Note Holder. The Note Holder hereby represents and warrants to the
Company as of the date the Note was issued as follows: 
 (a) Securities Law Compliance. The Note Holder has been
advised that this Note and the underlying securities have not been registered under the Securities Act, or any state securities laws, and, therefore, cannot be resold unless they are registered under the Securities Act and applicable state
securities laws or unless an exemption from such registration requirements is available. The Note Holder is aware that the Company is under no obligation to effect any such registration with respect to this Note or the underlying securities, except
as set forth in Section 3(d), or to file for or comply with any exemption from registration. The Note Holder, if an entity, has not been formed solely for the purpose of making this investment. The Note Holder is purchasing this Note to be
acquired by the Note Holder hereunder for the Note Holder’s own account for investment, not as a nominee or agent, and not with a view to, or for resale of this Note or the underlying securities in connection with, the distribution thereof, and
the Note Holder has no present intention of selling, granting any participation in, or otherwise distributing the same. The residency of the Note Holder (or, in the case of a partnership or corporation, such entity’s principal place of
business) is correctly set forth beneath the Note Holder’s name on the signature page hereto. 
 (b) Accredited
Investor. The Note Holder has such knowledge and experience in financial and business matters that the Note Holder is capable of evaluating the merits and risks of its investment in this Note, is able to incur a complete loss of such investment
without impairing the Note Holder’s financial condition and is able to bear the economic risk of such investment for an indefinite period of time. The Note Holder is an “accredited investor” as such term is defined in Rule 501 of
Regulation D under the Securities Act and will submit to the Company such further assurances of such status as may be reasonably requested by the Company. 

10. Representations and Warranties of the Company. The Company hereby represents and warrants to the Holder as of
the date the Note was issued as follows: 
 a) Organization, Good Standing and Qualification. The Company is a corporation duly
organized, validly existing and in good standing under the laws of the State of Delaware. The Company has the requisite corporate power to own and operate its properties and assets and to carry on its business as now conducted and as proposed to be
conducted. The Company is duly qualified and is authorized to do business and is in good standing as a foreign corporation in all jurisdictions in which the nature of its activities and of its properties (both owned and leased) makes such
qualification necessary, except for those jurisdictions in which failure to do so would not have a material adverse effect on the Company or its business (a “Material Adverse Effect”). 

b) Corporate Power. The Company has all requisite corporate power to issue this Note and to carry out and perform its obligations
under this Note. The Company’s Board of Directors (the “Board”) has approved the issuance of this Note based upon a reasonable belief that the issuance of this Note is appropriate for the Company after reasonable inquiry concerning
the Company’s financing objectives and financial situation. 
 c) Authorization. All corporate action on the part of the
Company, the Board and the Company’s stockholders necessary for the issuance and delivery of this Note has been taken. This Note constitutes a valid and 

  
 5 

 
binding obligation of the Company enforceable in accordance with its terms, subject to laws of general application relating to bankruptcy, insolvency, the relief of debtors and, with respect to
rights to indemnity, subject to federal and state securities laws. Any securities issued upon conversion of this Note (the “Conversion Securities”), when issued in compliance with the provisions of this Note, will be validly issued,
fully paid, nonassessable, free of any liens or encumbrances and issued in compliance with all applicable federal and securities laws. 

d) Governmental Consents. All consents, approvals, orders or authorizations of, or registrations, qualifications, designations,
declarations or filings with, any governmental authority required on the part of the Company in connection with issuance of this Note has been obtained. 

e) Compliance with Laws. To its knowledge, the Company is not in violation of any applicable statute, rule, regulation, order or
restriction of any domestic or foreign government or any instrumentality or agency thereof in respect of the conduct of its business or the ownership of its properties, which violation of which would have a Material Adverse Effect. 

f) Compliance with Other Instruments. The Company is not in violation or default of any term of its certificate of incorporation
or bylaws, or of any provision of any mortgage, indenture or contract to which it is a party and by which it is bound or of any judgment, decree, order or writ, other than such violation(s) that would not have a Material Adverse Effect. The
execution, delivery and performance of this Note will not result in any such violation or be in conflict with, or constitute, with or without the passage of time and giving of notice, either a default under any such provision, instrument, judgment,
decree, order or writ or an event that results in the creation of any lien, charge or encumbrance upon any assets of the Company or the suspension, revocation, impairment, forfeiture, or nonrenewal of any material permit, license, authorization or
approval applicable to the Company, its business or operations or any of its assets or properties. Without limiting the foregoing, the Company has obtained all waivers reasonably necessary with respect to any preemptive rights, rights of first
refusal or similar rights, including any notice or offering periods provided for as part of any such rights, in order for the Company to consummate the transactions contemplated hereunder without any third party obtaining any rights to cause the
Company to offer or issue any securities of the Company as a result of the consummation of the transactions contemplated hereunder. 

g) No “Bad Actor” Disqualification. The Company has exercised reasonable care to determine whether any Company Covered
Person (as defined below) is subject to any of the “bad actor” disqualifications described in Rule 506(d)(1)(i) through (viii), as modified by Rules 506(d)(2) and (d)(3), under the Securities Act (“Disqualification Events”). To
the Company’s knowledge, no Company Covered Person is subject to a Disqualification Event. The Company has complied, to the extent required, with any disclosure obligations under Rule 506(e) under the Act. For purposes of this Note,
“Company Covered Persons” are those persons specified in Rule 506(d)(1) under the Act; provided, however, that Company Covered Persons do not include (a) any Holder, or (b) any person or entity that is deemed to be an affiliated
issuer of the Company solely as a result of the relationship between the Company and any Holder. 
 h) Offering. The offer,
issue, and sale of this Note and the Conversion Securities (collectively, the “Securities”) are and will be exempt from the registration and prospectus delivery requirements of the Securities Act, and have been registered or
qualified (or are exempt from registration and qualification) under the registration, permit or qualification requirements of all applicable state securities laws. 

i) Use of Proceeds. The Company shall use the proceeds of this Note solely for the operations of its business, and not for any
personal, family or household purpose. 
 11. Transfer; Successors and Assigns. The Note Holder may sell,
assign, pledge, dispose of or otherwise transfer this Note or any interest herein without the prior written consent of the Company so long as the Note Holder provides the Company two (2) business days written notice of such transfer. Subject to
the preceding sentence, this Note may be transferred only upon surrender of the original Note (or affidavit of loss with any indemnity requested by the Company) for registration of transfer, duly endorsed, or accompanied by a duly executed written
instrument of transfer in form satisfactory to the Company. Thereupon, a new note for the same principal amount and interest will be issued by the Company to, and registered in the name, of, the transferee, who shall thereupon be deemed the
registered Note Holder. Interest and principal are payable only to the registered Note Holder. The terms and 

  
 6 

 
conditions of this Note shall inure to the benefit of and binding upon the respective successors and assigns of the parties. 

12. Governing Law. This Note and all acts and transactions pursuant hereto and the rights and obligations of the
parties hereto shall be governed, construed and interpreted in accordance with the laws of the State of California, without giving effect to principles of conflicts of law and choice of law that would cause the laws of any other jurisdiction to
apply. 
 13. Notices. All notices, requests and demands to or upon the respective parties hereto to be
effective shall be in writing, and, unless otherwise expressly provided herein, shall be deemed to have been duly given or made: (i) if delivered by hand, when received, (ii) if sent by a nationally recognized courier service, one business
day after delivery to such courier service, (iii) if transmitted by facsimile or e-mail, at the time such transmission is confirmed to the sender, (iv) if sent by certified mail, four business days
after delivery to the postal system, in each case addressed as follows in the case of the Company and the Note Holder or to such other address as may be hereafter notified by the respective parties hereto and any future holder(s) of this Note: 

 

			
	 Company:
	  	 11099 N. Torrey Pines Road, #100

La Jolla, CA 92037
 Attn: Steven
Kemper

		
	 With a copy to:
	  	 Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, PC

3850 Carmel Mountain Road
 Suite
300
 San Diego, CA 92130
 Attn:
Jeremy Glaser
 (which copy shall not constitute notice)

		
	 Note Holder:
	  	 RTW Investments, LP

		
	 With a copy to:
	  	 CrandonLaw

 14. Amendments and Waivers. This Note may be amended or modified, and any
provision hereof may be waived with the written consent of the Company and the Note Holder. No waivers of any term, condition or provision of this Note, in any one or more instances, shall be deemed to be, or construed as, a further or continuing
waiver of any such term, condition or provision. 
 15. Headings. The headings in this Note are for purposes of
reference only, and shall not limit or otherwise affect the meaning hereof. 
 16. Legal Fees. The Company shall reimburse the
Note Holder for its actual and reasonable legal fees incurred up to a maximum of $5,000. The Company shall reimburse the Note Holder for actual and reasonable costs, fees, and expenses of the Note Holder incurred by the Note Holder in enforcing any
of its rights hereunder following the occurrence of an Event of Default. 
 17. Rights Reserved. No provisions
of this Note and no right or option granted or conferred herein shall in any way limit, affect or abridge the exercise by the Company of any of its corporate rights or powers, including without limitation, its corporate right and power to issue
securities, recapitalize, amend its Amended and Restated Certificate of Incorporation, reorganize, consolidate or merge with or into another corporation, or transfer or encumber all or any part of its property or assets. 

[Signature Page Follows] 

  
 7 

 IN WITNESS WHEREOF, the Company has caused this Note to be duly executed and
delivered. 
  

			
	 DERMTECH, INC.

		
	 By:
	 	 /s/ Steven Kemper

	 Name: Steven Kemper

	 Title: Chief Financial Officer

  

			
	 AGREED AND ACCEPTED BY:

	
	 RTW MASTER FUND, LTD.

		
	 By:
	 	 /s/ Roderick Wong

	 Name: Roderick Wong

	 Title: Director

  
 [Signature Page to
Convertible Promissory Note]

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