Document:

Amendment of Marlene F. Perry Employment Commencement Nonstatutory Stock Option

 Exhibit 10.36 
 RENOVIS, INC. 
 AMENDMENT OF EMPLOYMENT COMMENCEMENT 
 NONSTATUTORY STOCK OPTION AGREEMENT 
 THIS AMENDMENT OF EMPLOYMENT COMMENCEMENT NONSTATUTORY STOCK OPTION AGREEMENT (the
“Amendment”) is entered into as of this 3rd day of January, 2007 (the “Effective Date”), between
Marlene F. Perry (the “Optionee”) and Renovis, Inc., a Delaware corporation (the “Company”). 
 RECITALS

 WHEREAS, the Optionee has previously been granted an option to purchase 43,496 shares of the Company’s common stock (the
“Option”) pursuant to an Employment Commencement Nonstatutory Stock Option Agreement between the Company and the Optionee, effective as of October 5, 2004 and the related Stock Option Grant Notice (together, the “Option
Agreement”); and 
 WHEREAS, the parties wish to amend the Option Agreement to clarify the effect of certain changes in capitalization
of the Company on the Option, pursuant to the terms and conditions set forth below. 
 AGREEMENT 
 NOW THEREFORE, in consideration of the foregoing and the mutual agreements contained herein and intending to be legally bound hereby, the parties hereby
agree as follows, effective as of the Effective Date: 
 1. Definition of Equity Restructuring. For purposes of this Amendment,
“Equity Restructuring” means a non-reciprocal transaction between the Company and its stockholders, such as a stock dividend, stock split, spin-off, rights offering or recapitalization through a large, nonrecurring cash dividend, that
affects the shares of Stock (or other securities of the Company) or the share price of Stock (or other securities) and causes a change in the per share value of the Stock underlying the Option. 
 2. Amendment of Changes in Capital Structure Provision. Section 7 of the Option Agreement is hereby amended as follows: 
 (a) Section 7(a) of the Option Agreement is hereby amended in its entirety to read as follows: 
 “(a) Equity Restructuring. In connection with the occurrence of any Equity Restructuring, and notwithstanding anything to the contrary in
Section 7(d), the number and type of securities subject to the Option and the exercise price per share thereof, as well as any other applicable terms and conditions of the Option, will be proportionately adjusted. The adjustments provided under
this Section 7(a) shall be nondiscretionary and shall be final and binding on the Optionee and the Company.” 

 (b) Section 7(d) of the Option Agreement is hereby amended in its entirety to read as follows:

 “(d) Outstanding Option – Other Changes. In the event that the Committee determines that other than an Equity
Restructuring, any dividend or other distribution (whether in the form of cash, Stock, other securities or other property), reorganization, merger, consolidation, combination, repurchase, liquidation, dissolution, or sale, transfer, exchange or
other disposition of all or substantially all of the assets of the Company, or exchange of Stock or other securities of the Company, issuance or warrants or other rights to purchase Stock or other securities of the Company or other similar corporate
transaction or event, in the Committee’s sole discretion, affects the Stock such that an adjustment is determined by the Committee to be appropriate in order to prevent dilution or enlargement of the benefits or potential benefits intended to
be made available under the Option, then the Committee shall, in such manner as it may deem equitable, adjust the number and kind of shares of Stock (or other securities or property) subject to the Option, the exercise price per share thereof,
and/or any other applicable terms and conditions of the Option.” 
 3. Complete Agreement. This Amendment and the Option
Agreement together constitute the entire agreement between Optionee and the Company with respect to the Option and they are the complete, final and exclusive embodiment of their agreement with regard to this subject matter. This Amendment is entered
into without reliance on any promise or representation other than those expressly contained herein. 
 4. Applicable Law. This
Amendment shall be governed by the law of the State of California as such laws are applied to agreements between California residents entered into and to be performed entirely within the State of California. 
 IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed as of the date first written above. 
  

			
	RENOVIS, INC.
		
	By:	 	 /s/ John C. Doyle

	Name:	 	John C. Doyle
	Title:	 	Senior Vice President, Finance & Operations, Chief Financial Officer
	
	OPTIONEE
	
	 /s/ Marelene F. Perry

	Marlene F. PerryFifth Amendment to Loan and Subordinated Debenture Purchase Agreement

 Exhibit 10.46 
  
 FIFTH AMENDMENT 
  
 TO 
  
 LOAN AND SUBORDINATED DEBENTURE PURCHASE AGREEMENT 
  
 BETWEEN 
  
 LASALLE BANK NATIONAL ASSOCIATION 
  
 AND

  
 TAYLOR CAPITAL GROUP, INC. 
  
 Fifth Amendment dated as of December 28, 2006 
 Fourth Amendment dated as of January 12, 2006 
 Third Amendment dated as of December 9, 2004 
 Second Amendment dated as of June 8, 2004 
 First Amendment dated as of November 27, 2003 
 Original Loan and Subordinated Debenture Purchase Agreement dated as of November 27, 2002 

 AMENDMENT PROVISIONS: PAGE 
  

					
	A.	  	Amendment to Definition of “Revolving Loan Amount”	  	1
			
	B.	  	Representations and Warranties	  	1
			
	C.	  	Conditions	  	2
			
	D.	  	Additional Terms	  	2

  
  

 FIFTH AMENDMENT TO 
 LOAN AND SUBORDINATED DEBENTURE PURCHASE AGREEMENT 
  
 This FIFTH AMENDMENT TO LOAN AND SUBORDINATED DEBENTURE PURCHASE AGREEMENT (“Fifth Amendment”), dated as of December 28, 2006, is entered into by and between TAYLOR CAPITAL GROUP, INC., a Delaware
corporation (“Borrower”), and LASALLE BANK NATIONAL ASSOCIATION, a national banking association (“Lender”). 
  
 R E C I T A L S : 
  
 A. The parties hereto have entered into that certain Loan and Subordinated Debenture Purchase Agreement, dated as of November 27, 2002, as previously
amended, restated, supplemented or modified from time to time, including by that certain First Amendment to Loan and Subordinated Debenture Purchase Agreement, dated as of November 27, 2003, that certain Second Amendment to Loan and
Subordinated Debenture Purchase Agreement, dated as of June 8, 2004, that certain Third Amendment to Loan and Subordinated Debenture Purchase Agreement, dated as of December 9, 2004, and that certain Fourth Amendment to Loan and
Subordinated Purchase Agreement, dated as of January 12, 2006 (as so amended, restated, supplemented or modified, the “2002 Loan Agreement”). 
  
 B. The parties hereto desire to amend and modify the 2002 Loan Agreement in accordance with the terms and subject to the conditions set forth in this
Fifth Amendment. As amended and modified by this Fifth Amendment, the 2002 Loan Agreement may be referred to as the “Agreement.” 
  
 C. The parties desire to amend the terms of the 2002 Loan Agreement to extend the Revolving Loan Maturity Date. The parties agree to undertake such
modification in accordance with the terms, subject to the conditions, and in reliance upon the recitals, representations, warranties, and covenants set forth herein, in the Agreement, and in the other Loan Documents, irrespective of whether entered
into or delivered on or after November 27, 2002. 
  
 D.
Capitalized terms used but not otherwise defined in this Fifth Amendment shall have the meanings respectively ascribed to them in the 2002 Loan Agreement. 
  
 NOW, THEREFORE, in consideration of the mutual representations, warranties, covenants and agreements hereinafter set forth, and for other good and
valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby agree as follows: 
  
 A G R E E M E N T : 
  
 A. Amendment to Definition of “Revolving Loan Maturity Date”. The term “Revolving Loan Maturity Date” is hereby deleted
from subsection 1.1 of the 2002 Loan Agreement and replaced in its entirety with the following: 
  
 ““Revolving Loan Maturity Date” means November 27, 2007.” 
  
 B. Representations and Warranties. Borrower hereby represents
and warrants to the Lender as follows: 
  
 (i) No
Event of Default or Potential Event of Default has occurred and is continuing (or would result from the amendments contemplated hereby). 
  
 (ii) The execution, delivery and performance by the Borrower of this Fifth Amendment have been duly authorized by all necessary corporate
and other action and do not and will not require any registration with, consent or approval of, or notice to or action by any Person (including any Governmental Agency) in order to be effective and enforceable. 
  
 (iii) This Fifth Amendment, and the other Loan Documents (as
amended by this Fifth Amendment) constitute the legal, valid and binding obligations of the Borrower, enforceable against the Borrower in accordance with their respective terms. 
  
 (iv) All representations and warranties of the Borrower in the 2002 Loan Agreement are true and correct,
except, for the purposes of this Fifth Amendment only, all references in Section 4 of the 

 
2002 Loan Agreement to (x) the term “Borrower 2001 Audited Financial Statements Date” shall be deemed to refer to “December 31, 2005 (as
restated)”; (y) the term “Borrower 2001 Audited Financial Statements” shall be deemed to refer to “the consolidated and consolidating audited financial statements of the Borrower as of the year ending December 31, 2005
(as restated)”; and (z) the term “Interim Financial Statements Date” shall be deemed to refer to call reports and regulatory filings (including Form FRY-9C filings) by the Subsidiary Bank for the period ending “September 30,
2006.” 
  
 (v) The Borrower’s
obligations under the Agreement and under the other Loan Documents are not subject to any defense, counterclaim, set-off, right to recoupment, abatement or other claim. 
  
 C. Conditions. Notwithstanding anything to the contrary contained elsewhere in the Agreement, the obligation
of Lender to extend the Revolving Loan Maturity Date and otherwise modify the 2002 Loan Agreement as contemplated by this Fifth Amendment shall be subject to the performance by the Borrower prior to the date on which this Fifth Amendment is executed
(the “Amendment Closing Date”) of all of its agreements theretofore to be performed under the Agreement and to the satisfaction of the following conditions precedent. The obligations to continue to make disbursements of proceeds under the
Loans are, and shall remain, subject to the conditions precedent in the 2002 Loan Agreement and to the receipt by the Lender of all the following in form and substance satisfactory to the Lender and its counsel, and, where appropriate, duly executed
and dated the Amendment Closing Date: 
  
 (i) a
certificate of good standing of the Borrower, certified by the appropriate governmental official in its jurisdiction of incorporation and dated within the five business days preceding the date hereof; 
  
 (ii) copies, certified by the Secretary or Assistant
Secretary of the Borrower, of the (a) resolutions duly adopted by the board of directors of the Borrower authorizing the execution, delivery and performance of this Fifth Amendment and the other documents to be delivered by the Borrower
pursuant to this Fifth Amendment (the “Amendment-Related Documents”), and (b) the Bylaws of the Borrower as currently in effect; and 
  
 (iii) such other documents, agreements or instruments as Lender may reasonably request. 
  
 D. Additional Terms. 
  
 (i) Acknowledgment of Indebtedness under Agreement.
The Borrower acknowledges and confirms that, as of the date hereof, the Borrower is indebted to the Lender, without defense, setoff, or counterclaim, in the aggregate principal amount of Zero Dollars ($0.00) under the Revolving Loan. 
  
 (ii) Effectiveness. This Fifth Amendment is hereby
deemed to be effective as of November 27, 2006. 
  
 (iii) The Agreement. All references in the 2002 Loan Agreement to the term “Agreement” shall be deemed to refer to the Agreement referenced in this Fifth Amendment. 
  
 (iv) Fifth Amendment and 2002 Loan Agreement to be Read
Together. This Fifth Amendment supplements and is hereby made a part of the 2002 Loan Agreement, and the 2002 Loan Agreement and this Fifth Amendment shall from and after the date hereof be read together and shall constitute the Agreement.
Except as otherwise set forth herein, the 2002 Loan Agreement shall remain in full force and effect. 
  
 (v) Loan Documents. The term “Loan Documents,” as used in the Agreement, shall from and after the date hereof include the
Amendment-Related Documents. 

 (vi) Counterparts. This Fifth Amendment may be executed by facsimile in one or
more counterparts, each of which shall be deemed an original and all of which taken together shall constitute one and the same document.” 
  
 [Remainder of Page Intentionally Left Blank] 

 IN WITNESS WHEREOF, the Borrower and the Lender have executed this Fifth Amendment as of the date first
written above. 
  
  

			
	 TAYLOR CAPITAL GROUP, INC.

		
	By:	 	/S/    ROBIN VANCASTLE        
	 	 	 Name: Robin VanCastle
 Title: Chief Accounting
Officer

  

			
	LASALLE BANK NATIONAL ASSOCIATION
		
	By:	 	/S/    RICHARD T. ZELL        
	 	 	 Name: Richard T. Zell
 Title: First Vice
President

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