Document:

Amended and Restated Investor Rights Agreement dated as of November 17, 2003

 Exhibit 4.3 
  

THRESHOLD PHARMACEUTICALS, INC. 
  
 AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 
  
 November 17, 2003 
  

 TABLE OF CONTENTS 
  

					
	 	  	 	  	Page

		
	 1.      GENERAL
	  	1
			
	 1.1
	  	 Amendment and Restatement of Prior Agreement
	  	1
			
	 1.2
	  	 Definitions
	  	2
		
	 2.      REGISTRATION; RESTRICTIONS ON TRANSFER
	  	3
			
	 2.1
	  	 Restrictions on Transfer
	  	3
			
	 2.2
	  	 Demand Registration
	  	4
			
	 2.3
	  	 Piggyback Registrations
	  	5
			
	 2.4
	  	 Form S-3 Registration
	  	6
			
	 2.5
	  	 Expenses of Registration
	  	8
			
	 2.6
	  	 Obligations of the Company
	  	8
			
	 2.7
	  	 Termination of Registration Rights
	  	9
			
	 2.8
	  	 Delay of Registration; Furnishing Information
	  	10
			
	 2.9
	  	 Indemnification
	  	10
			
	 2.10
	  	 Assignment of Registration Rights
	  	12
			
	 2.11
	  	 Amendment of Registration Rights
	  	12
			
	 2.12
	  	 Limitation on Subsequent Registration Rights
	  	12
			
	 2.13
	  	 “Market Stand-Off” Agreement
	  	13
			
	 2.14
	  	 Agreement to Furnish Information
	  	13
			
	 2.15
	  	 Rule 144 Reporting
	  	13
		
	 3.      COVENANTS OF THE COMPANY
	  	14
			
	 3.1
	  	 Basic Financial Information and Reporting
	  	14
			
	 3.2
	  	 Inspection Rights
	  	14
			
	 3.3
	  	 Confidentiality of Records
	  	14
			
	 3.4
	  	 Reservation of Common Stock
	  	15
			
	 3.5
	  	 Proprietary Information and Inventions Agreement
	  	15
			
	 3.6
	  	 Stock Vesting
	  	15
			
	 3.7
	  	 Key Man Insurance
	  	15

  

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	 3.8
	  	 Directors’ Liability and Indemnification; D & O Insurance
	  	15
			
	 3.9
	  	 Assignment of Right of First Refusal
	  	15
			
	 3.10
	  	 Expenses of Non-employee Directors and Board Observers
	  	16
			
	 3.11
	  	 Visitation Rights
	  	16
			
	 3.12
	  	 Restrictions on Operations
	  	16
			
	 3.13
	  	 Termination of Covenants
	  	16
		
	 4.      RIGHTS OF FIRST REFUSAL
	  	16
			
	 4.1
	  	 Subsequent Offerings
	  	16
			
	 4.2
	  	 Exercise of Rights
	  	17
			
	 4.3
	  	 Issuance of Equity Securities to Other Persons
	  	17
			
	 4.4
	  	 Termination and Waiver of Rights of First Refusal
	  	17
			
	 4.5
	  	 Transfer of Rights of First Refusal
	  	17
			
	 4.6
	  	 Excluded Securities
	  	17
		
	 5.      MISCELLANEOUS
	  	18
			
	 5.1
	  	 Governing Law
	  	18
			
	 5.2
	  	 Survival
	  	18
			
	 5.3
	  	 Successors and Assigns
	  	18
			
	 5.4
	  	 Entire Agreement
	  	19
			
	 5.5
	  	 Severability
	  	19
		
	 6.      AMENDMENT AND WAIVER
	  	19
			
	 6.2
	  	 Delays or Omissions
	  	19
			
	 6.3
	  	 Notices
	  	20
			
	 6.4
	  	 Attorneys’ Fees
	  	20
			
	 6.5
	  	 Titles and Subtitles
	  	20
			
	 6.6
	  	 Additional Investors
	  	20
			
	 6.7
	  	 Counterparts
	  	20
			
	 6.8
	  	 Aggregation of Stock
	  	20

  

 ii 

 THRESHOLD PHARMACEUTICALS, INC. 
  
 SERIES B INVESTOR RIGHTS AGREEMENT 
  
 THIS AMENDED AND RESTATED INVESTOR
RIGHTS AGREEMENT (the “Agreement”) is entered into as of the 17th day of November, 2003, by and among THRESHOLD PHARMACEUTICALS,
INC., a Delaware corporation (the “Company”) and the investors listed on Exhibit A hereto, referred to hereinafter as the “Investors” and each individually as an
“Investor.” 
  
 RECITALS

  
 WHEREAS, the certain
of the Investors are purchasing shares of the Company’s Series B Preferred Stock (the “Series B Stock”), pursuant to that certain Series B Preferred Stock Purchase Agreement (the “Purchase
Agreement”) of even date herewith (the “Financing”); 
  
 WHEREAS, the obligations in the Purchase Agreement are conditioned upon the execution and delivery of this Agreement; 
  
 WHEREAS, certain of the Investors (the “Prior Investors”) are
holders of the Company’s Series A Preferred Stock (the “Series A Stock,” the Series A Stock and Series B Stock shall be referred to herein collectively as the “Preferred Stock”); 
  
 WHEREAS, the Prior Investors and the
Company are parties to an Amended and Restated Investor Rights Agreement dated August 15, 2002 (the “Prior Agreement”); 
  
 WHEREAS, the parties to the Prior Agreement desire to amend and restate the Prior Agreement and accept the rights and
covenants hereof in lieu of their rights and covenants under the Prior Agreement; and 
  
 WHEREAS, in connection with the consummation of the Financing, the Company and the Investors have agreed to the registration rights, information rights, and other rights as set
forth below. 
  
 NOW,
THEREFORE, in consideration of these premises and for other good and valid consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 
  
 1. GENERAL 
  
 1.1 Amendment and Restatement of Prior Agreement. The Prior Agreement
is hereby amended in its entirety and restated herein. Such amendment and restatement is effective upon the execution of the Agreement by the Company and by the holders of a majority of the Series A Stock held by the Prior Investors outstanding as
of the date of this Agreement. Upon such execution, all provisions of, rights granted and covenants made in the Prior Agreement are hereby waived, released and superseded in their entirety and shall have no further force or effect, including,
without limitation, all rights of first refusal and any notice period associated therewith otherwise applicable to the transactions contemplated by the Purchase Agreement. 
  

 1.2 Definitions. As used in this Agreement the following terms shall have the following respective
meanings: 
  
 (a) “Exchange
Act” means the Securities Exchange Act of 1934, as amended. 
  
 (b) “Form S-3” means such form under the Securities Act as in effect on the date hereof or any successor or similar registration form under the Securities Act subsequently adopted by the SEC
which permits inclusion or incorporation of substantial information by reference to other documents filed by the Company with the SEC. 
  
 (c) “Holder” means any person owning of record Registrable Securities that have not been sold to the public or any
assignee of record of such Registrable Securities in accordance with Section 2.10 hereof. 
  
 (d) “Initial Offering” means the Company’s first firm commitment underwritten public offering of its Common
Stock registered under the Securities Act. 
  
 (e) “Major Investor” has the meaning set forth in Section 3.1(c). 
  
 (f) “Register,” “registered,” and “registration” refer to a
registration effected by preparing and filing a registration statement in compliance with the Securities Act, and the declaration or ordering of effectiveness of such registration statement or document. 
  
 (g) “Registrable Securities” means
(a) Common Stock of the Company issued or issuable upon conversion of the Shares and (b) any Common Stock of the Company issued as (or issuable upon the conversion or exercise of any warrant, right or other security which is issued as) a dividend or
other distribution with respect to, or in exchange for or in replacement of, such above-described securities. Notwithstanding the foregoing, Registrable Securities shall not include any securities sold by a person to the public either pursuant to a
registration statement or Rule 144 or sold in a private transaction in which the transferor’s rights under Section 2 of this Agreement are not assigned. 
  

(h) “Registration Expenses” shall mean all expenses incurred by the Company in complying with Sections 2.2, 2.3
and 2.4 hereof, including, without limitation, all registration and filing fees, printing expenses, fees and disbursements of counsel for the Company, reasonable fees and disbursements not to exceed $25,000 of a single special counsel for the
Holders, blue sky fees and expenses and the expense of any special audits incident to or required by any such registration (but excluding the compensation of regular employees of the Company which shall be paid in any event by the Company).

  
 (i) “SEC” or
“Commission” means the Securities and Exchange Commission. 
  
 (j) “Securities Act” shall mean the Securities Act of 1933, as amended. 
  
 (k) “Selling Expenses” shall mean
all underwriting discounts and selling commissions applicable to the sale. 
  
 (l) “Shares” shall mean the Company’s Series A Stock and Series B Stock held by the Investors listed on Exhibit A hereto and their permitted assigns. 
  

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 (m) “Special Registration Statement” shall mean (i) a
registration statement relating to any employee benefit plan or (ii) with respect to any corporate reorganization or transaction under Rule 145 of the Securities Act, including any registration statements related to the resale of securities issued
in such a transaction or (iii) a registration related to stock issued upon conversion of debt securities. 
  
 2. REGISTRATION; RESTRICTIONS ON TRANSFER. 
  
 2.1 Restrictions on Transfer. 
  
 (a) Each Holder agrees not to make any disposition of all or any portion of the Shares or Registrable Securities unless and until:

  
 (i) There is then in effect a registration
statement under the Securities Act covering such proposed disposition and such disposition is made in accordance with such registration statement; or 
  
 (ii) (A) The transferee has agreed in writing to be bound by the terms of this Agreement, (B) such Holder shall have notified the Company
of the proposed disposition and shall have furnished the Company with a detailed statement of the circumstances surrounding the proposed disposition, and (C) if reasonably requested by the Company, such Holder shall have furnished the Company with
an opinion of counsel, reasonably satisfactory to the Company, that such disposition will not require registration of such shares under the Securities Act. It is agreed that the Company will not require opinions of counsel for transactions made
pursuant to Rule 144, except in unusual circumstances. After its Initial Offering, the Company will not require the transferee to be bound by the terms of this Agreement. 
  
 (iii) Notwithstanding the provisions of paragraphs (i) and (ii) above, no such registration statement or
opinion of counsel shall be necessary for a transfer by a Holder that is (A) a partnership transferring to its partners, former partners or affiliates in accordance with partnership interests, (B) a corporation transferring to a wholly-owned
subsidiary or a parent corporation that owns all of the capital stock of the Holder, (C) a limited liability company transferring to its members, former members or affiliates in accordance with their interest in the limited liability company, or (D)
an individual transferring to the Holder’s family member or trust for the benefit of an individual Holder; provided that in each case the transferee will be subject to the terms of this Agreement to the same extent as if he were an original
Holder hereunder. 
  
 (b) Each certificate
representing Shares or Registrable Securities shall (unless otherwise permitted by the provisions of the Agreement) be stamped or otherwise imprinted with a legend substantially similar to the following (in addition to any legend required under
applicable state securities laws): 
  
 THE SECURITIES REPRESENTED
HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933 (THE “ACT”) AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR UNLESS THE COMPANY HAS
RECEIVED AN OPINION OF COUNSEL 

  

 3 

 
SATISFACTORY TO THE COMPANY AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED. 
  
 (c) The Company shall be obligated to reissue promptly unlegended certificates at the request of any Holder
thereof if the Holder shall have obtained an opinion of counsel (which counsel may be counsel to the Company) reasonably acceptable to the Company to the effect that the securities proposed to be disposed of may lawfully be so disposed of without
registration, qualification or legend. 
  
 (d)
Any legend endorsed on an instrument pursuant to applicable state securities laws and the stop-transfer instructions with respect to such securities shall be removed upon receipt by the Company of an order of the appropriate blue sky authority
authorizing such removal. 
  
 2.2 Demand Registration

  
 (a) Subject to the conditions of this
Section 2.2, if after the first anniversary of the closing of the Series B financing, the Company shall receive a written request from the Holders of 75% of the Registrable Securities (the “Initiating Holders”) that the
Company file a registration statement under the Securities Act covering the registration of at least a majority of the Registrable Securities then outstanding (a “Qualified Public Offering”), then the Company shall, within 30
days of the receipt thereof, give written notice of such request to all Holders, and subject to the limitations of this Section 2.2, effect, as expeditiously as reasonably possible, the registration under the Securities Act of all Registrable
Securities that the Holders request to be registered. 
  
 (b) If the Initiating Holders intend to distribute the Registrable Securities covered by their request by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to this Section 2.2 or any request
pursuant to Section 2.4 and the Company shall include such information in the written notice referred to in Section 2.2(a) or Section 2.4(a), as applicable. In such event, the right of any Holder to include its Registrable Securities in such
registration shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their
securities through such underwriting shall enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by a majority in interest of the Initiating Holders (which underwriter or
underwriters shall be reasonably acceptable to the Company). Notwithstanding any other provision of this Section 2.2 or Section 2.4, if the underwriter advises the Company that marketing factors require a limitation of the number of securities to be
underwritten (including Registrable Securities) then the Company shall so advise all Holders of Registrable Securities which would otherwise be underwritten pursuant hereto, and the number of shares that may be included in the underwriting shall be
allocated to the Holders of such Registrable Securities on a pro rata basis based on the number of Registrable Securities held by all such Holders (including the Initiating Holders). Any Registrable Securities excluded or withdrawn from such
underwriting shall be withdrawn from the registration. 
  

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 (c) The Company shall not be required to effect a registration pursuant to this Section
2.2: 
  
 (i) prior to 180 days following the
effective date of the registration statement pertaining to the Initial Offering; 
  
 (ii) after the Company has effected two registrations pursuant to this Section 2.2, and such registrations have been declared or ordered
effective; 
  
 (iii) during the period starting
with the date of filing of, and ending on the date 180 days following the effective date of the registration statement pertaining to a public offering, other than pursuant to a Special Registration Statement; provided that the Company makes
reasonable good faith efforts to cause such registration statement to become effective; 
  
 (iv) if within 30 days of receipt of a written request from Initiating Holders pursuant to Section 2.2(a), the Company gives notice to the
Holders of the Company’s intention to file a registration statement for a public offering, other than pursuant to a Special Registration Statement within 90 days; 
  
 (v) if the Company shall furnish to Holders requesting a registration statement pursuant to this Section
2.2, a certificate signed by the Chairman of the Board stating that in the good faith judgment of the Board of Directors of the Company, it would be seriously detrimental to the Company and its stockholders for such registration statement to be
effected at such time, in which event the Company shall have the right to defer such filing for a period of not more than 120 days after receipt of the request of the Initiating Holders; provided that such right to delay a request shall be exercised
by the Company not more than once in any twelve month period; 
  
 (vi) if the Initiating Holders propose to dispose of shares of Registrable Securities that may be immediately registered on Form S-3 pursuant to a request made pursuant to Section 2.4 below; 
  
 (vii) in any particular jurisdiction in which the Company
would be required to qualify to do business or to execute a general consent to service of process in effecting such registration, qualification or compliance; or 
  
 (viii) if the registration would result in an offering with total proceeds of less than $50,000,000.

  
 2.3 Piggyback Registrations. The Company shall notify
all Holders of Registrable Securities in writing at least 15 days prior to the filing of any registration statement under the Securities Act for purposes of a public offering of securities of the Company (including, but not limited to, registration
statements relating to secondary offerings of securities of the Company, but excluding Special Registration Statements) and will afford each such Holder an opportunity to include in such registration statement all or part of such Registrable
Securities held by such Holder. Each Holder desiring to include in any such registration statement all or any part of the Registrable Securities held by it shall, within 15 days after the above-described notice from the Company, so notify the
Company in writing. Such notice shall state the intended method of disposition of the Registrable Securities by such Holder. If 

  

 5 

 
a Holder decides not to include all of its Registrable Securities in any registration statement thereafter filed by the Company, such Holder shall
nevertheless continue to have the right to include any Registrable Securities in any subsequent registration statement or registration statements as may be filed by the Company with respect to offerings of its securities, all upon the terms and
conditions set forth herein. 
  
 (a)
Underwriting. If the registration statement under which the Company gives notice under this Section 2.3 is for an underwritten offering, the Company shall so advise the Holders of Registrable Securities. In such event, the right of any
such Holder to be included in a registration pursuant to this Section 2.3 shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the
extent provided herein. All Holders proposing to distribute their Registrable Securities through such underwriting shall enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by
the Company. Notwithstanding any other provision of this Agreement, if the underwriter determines in good faith that marketing factors require a limitation of the number of shares to be underwritten, the number of shares that may be included in the
underwriting shall be allocated, first, to the Company; second, to the Holders on a pro rata basis based on the total number of Registrable Securities held by the Holders; and third, subject to Section 2.3(b), to any stockholder of the Company
(other than a Holder) on a pro rata basis; provided, however that, unless the registration is with respect to the Company’s initial public offering, in no event shall the shares to be sold by the Holders be reduced below 30% of the total amount
of securities included in the registration. If any Holder disapproves of the terms of any such underwriting, such Holder may elect to withdraw therefrom by written notice to the Company and the underwriter, delivered at least ten business days prior
to the effective date of the registration statement. Any Registrable Securities excluded or withdrawn from such underwriting shall be excluded and withdrawn from the registration. For any Holder which is a partnership or corporation, the partners,
retired partners and shareholders of such Holder, or the estates and family members of any such partners and retired partners and any trusts for the benefit of any of the foregoing person shall be deemed to be a single
“Holder,” and any pro rata reduction with respect to such “Holder” shall be based upon the aggregate amount of shares carrying registration rights owned by all entities and individuals included in such
“Holder,” as defined in this sentence. 
  
 (b) No stockholder of the Company shall be granted piggyback registration rights which would reduce the number of shares includable by the holders of the Registrable Securities in such registration without the written
consent of the holders of at least two-thirds of the Registrable Securities. 
  
 (c) Right to Terminate Registration. The Company shall have the right to terminate or withdraw any registration initiated by it under this Section 2.3 prior to the effectiveness of such registration
whether or not any Holder has elected to include securities in such registration. The Registration Expenses of such withdrawn registration shall be borne by the Company in accordance with Section 2.5 hereof. 
  
 2.4 Form S-3 Registration. In case the Company shall receive from any
Holder or Holders of Registrable Securities a written request or requests that the Company effect a registration on Form S-3 (or any successor to Form S-3) or any similar short-form registration statement and any related qualification or compliance
with respect to all or a part of the Registrable Securities owned by such Holder or Holders, the Company will: 
  
 (a) promptly give written notice of the proposed registration, and any related qualification or compliance, to all other Holders of
Registrable Securities; and 
  

 6 

 (b) as soon as practicable, effect such registration and all such qualifications and
compliances as may be so requested and as would permit or facilitate the sale and distribution of all or such portion of such Holder’s or Holders’ Registrable Securities as are specified in such request, together with all or such portion
of the Registrable Securities of any other Holder or Holders joining in such request as are specified in a written request given within 15 days after receipt of such written notice from the Company; provided, however, that the Company shall not be
obligated to effect any such registration, qualification or compliance pursuant to this Section 2.4: 
  
 (i) if Form S-3 is not available for such offering by the Holders, or 
  
 (ii) if the Holders, together with the holders of any other securities of the Company entitled to inclusion
in such registration, propose to sell Registrable Securities and such other securities (if any) at an aggregate price to the public of less than $1,000,000, or 
  

(iii) if within 30 days of receipt of a written request from any Holder or Holders pursuant to this Section 2.4, the Company gives
notice to such Holder or Holders of the Company’s intention to make a public offering within 90 days, other than pursuant to a Special Registration Statement provided that such Holders were permitted to register such shares as requested to be
registered pursuant to Section 2.3 hereof; or 
  
 (iv) if the Company shall furnish to the Holders a certificate signed by the Chairman of the Board of Directors of the Company stating that in the good faith judgment of the Board of Directors of the Company, it would be seriously
detrimental to the Company and its stockholders for such Form S-3 registration to be effected at such time, in which event the Company shall have the right to defer the filing of the Form S-3 registration statement for a period of not more than 120
days after receipt of the request of the Holder or Holders under this Section 2.4; provided, that such right to delay a request shall be exercised by the Company not more than once in any twelve month period, or 
  
 (v) if the Company has, within the twelve month period
preceding the date of such request, already effected two registrations on Form S-3 for the Holders pursuant to this Section 2.4, or 
  
 (vi) in any particular jurisdiction in which the Company would be required to qualify to do business or to execute a general consent to
service of process in effecting such registration, qualification or compliance. 
  
 (c) Subject to the foregoing, the Company shall file a Form S-3 registration statement covering the Registrable Securities and other
securities so requested to be registered as soon as practicable after receipt of the requests of the Holders. Registrations effected pursuant to this Section 2.4 shall not be counted as demands for registration or registrations effected pursuant to
Sections 2.2 or 2.3, respectively. All Registration Expenses incurred in connection with registrations requested pursuant to this Section 2.4 after the first two registrations shall be paid by the selling Holders pro rata in proportion to the number
of shares sold by each such Holder. 
  

 7 

 2.5 Expenses of Registration. Except as specifically provided herein, all Registration Expenses
incurred in connection with any registration, qualification or compliance pursuant to Section 2.2 or any registration under Section 2.3 or Section 2.4 herein shall be borne by the Company, including the expenses of one special counsel of the
selling Holders not to exceed $25,000 per registration. All Selling Expenses incurred in connection with any registrations hereunder, shall be borne by the holders of the securities so registered pro rata on the basis of the number of shares so
registered. The Company shall not, however, be required to pay for expenses of any registration proceeding begun pursuant to Section 2.2 or 2.4, the request of which has been subsequently withdrawn by the Initiating Holders unless (a) the withdrawal
is based upon material adverse information concerning the Company of which the Initiating Holders were not aware at the time of such request or (b) the Holders of a majority of Registrable Securities agree to forfeit their right to one demand
registration pursuant to Section 2.2 or Section 2.4, as applicable, in which event such right shall be forfeited by all Holders). If the Holders are required to pay the Registration Expenses, such expenses shall be borne by the holders of securities
(including Registrable Securities) requesting such registration in proportion to the number of shares for which registration was requested. If the Company is required to pay the Registration Expenses of a withdrawn offering pursuant to clause (a)
above, then the Holders shall not forfeit their rights pursuant to Section 2.2 or Section 2.4 to a demand registration. 
  
 2.6 Obligations of the Company. Whenever required to effect the registration of any Registrable Securities, the Company shall, as expeditiously as
reasonably possible: 
  
 (a) Prepare and file
with the SEC a registration statement with respect to such Registrable Securities and use all reasonable efforts to cause such registration statement to become effective, and, upon the request of the Holders of a majority of the Registrable
Securities registered thereunder, keep such registration statement effective for up to 30 days or, if earlier, until the Holder or Holders have completed the distribution related thereto; provided, however, that at any time, upon written notice to
the participating Holders and for a period not to exceed 120 days thereafter (the “Suspension Period”), the Company may delay the filing or effectiveness of any registration statement or suspend the use or effectiveness of
any registration statement (and the Initiating Holders hereby agree not to offer or sell any Registrable Securities pursuant to such registration statement during the Suspension Period) if the Company reasonably believes that the Company may, in the
absence of such delay or suspension hereunder, be required under state or federal securities laws to disclose any corporate development the disclosure of which could reasonably be expected to have an adverse effect upon the Company, its
stockholders, a potentially significant transaction or event involving the Company, or any negotiations, discussions, or proposals directly relating thereto. No more than one such Suspension Periods shall occur in any twelve (12) month period.
In the event that the Company shall exercise its rights hereunder, the applicable time period during which the registration statement is to remain effective shall be extended by a period of time equal to the duration of the Suspension Period.
The Company may extend the Suspension Period for an additional consecutive 120 days with the consent of the holders of a majority of the Registrable Securities proposed to be sold by the Initiating Holders, which consent shall not be unreasonably
withheld. If so directed by the Company, the Initiating Holders shall use their best efforts to deliver to the Company (at the Company’s expense) all copies, other than permanent file copies then in such Initiating Holders’ possession, of
the prospectus relating to such Registrable Securities current at the time of receipt of such notice. The Company shall not be required to file, cause to become effective or maintain the 

  

 8 

 
effectiveness of any registration statement that contemplates a distribution of securities on a delayed or continuous basis pursuant to Rule 415 under the
Securities Act. 
  
 (b) Prepare and file with the
SEC such amendments and supplements to such registration statement and the prospectus used in connection with such registration statement as may be necessary to comply with the provisions of the Securities Act with respect to the disposition of all
securities covered by such registration statement for the period set forth in paragraph (a) above. 
  
 (c) Furnish to the Holders such number of copies of a prospectus, including a preliminary prospectus, in conformity with the requirements
of the Securities Act, and such other documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them. 
  

(d) Use its reasonable efforts to register and qualify the securities covered by such registration statement under such other
securities or Blue Sky laws of such jurisdictions as shall be reasonably requested by the Holders; provided that the Company shall not be required in connection therewith or as a condition thereto to qualify to do business or to file a general
consent to service of process in any such states or jurisdictions. 
  
 (e) In the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and customary form, with the managing underwriter(s) of such offering. Each Holder
participating in such underwriting shall also enter into and perform its obligations under such an agreement. 
  
 (f) Notify each Holder of Registrable Securities covered by such registration statement at any time when a prospectus relating thereto is
required to be delivered under the Securities Act of the happening of any event as a result of which the prospectus included in such registration statement, as then in effect, includes an untrue statement of a material fact or omits to state a
material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing. The Company will use reasonable efforts to amend or supplement such prospectus in order to cause
such prospectus not to include any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing.

  
 (g) Use its reasonable efforts to furnish, on
the date that such Registrable Securities are delivered to the underwriters for sale, if such securities are being sold through underwriters, (i) an opinion, dated as of such date, of the counsel representing the Company for the purposes of such
registration, in form and substance as is customarily given to underwriters in an underwritten public offering, addressed to the underwriters, if any, and (ii) a letter, dated as of such date, from the independent certified public accountants of the
Company, in form and substance as is customarily given by independent certified public accountants to underwriters in an underwritten public offering addressed to the underwriters. 
  
 2.7 Termination of Registration Rights. All registration rights granted under this Section 2 shall terminate and be
of no further force and effect five years after the date of the Company’s Initial Offering. In addition, a Holder’s registration rights shall expire if (a) the Company has completed its Initial Offering and is subject to the provisions of
the Exchange Act, (b) such Holder (together with its affiliates) holds less than 1% of the Company’s 

  

 9 

 
outstanding Common Stock (treating all shares of convertible Preferred Stock on an as converted basis) and (c) all Registrable Securities held by and
issuable to such Holder (and its affiliates) may be sold under Rule 144 during any 90 day period. 
  
 2.8 Delay of Registration; Furnishing Information. 
  
 (a) No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any such registration as the result
of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 
  
 (b) It shall be a condition precedent to the obligations of the Company to take any action pursuant to Section 2.2, 2.3 or 2.4 that the
selling Holders shall furnish to the Company such information regarding themselves, the Registrable Securities held by them and the intended method of disposition of such securities as shall be required to effect the registration of their
Registrable Securities. 
  
 (c) The Company shall
have no obligation with respect to any registration requested pursuant to Section 2.2 or Section 2.4 if, due to the operation of subsection 2.2(b), the number of shares or the anticipated aggregate offering price of the Registrable Securities to be
included in the registration does not equal or exceed the number of shares or the anticipated aggregate offering price required to originally trigger the Company’s obligation to initiate such registration as specified in Section 2.2 or Section
2.4, whichever is applicable. 
  
 2.9 Indemnification. In
the event any Registrable Securities are included in a registration statement under Sections 2.2, 2.3 or 2.4: 
  
 (a) To the extent permitted by law, the Company will indemnify and hold harmless each Holder, the partners, officers and directors of each
Holder, any underwriter (as defined in the Securities Act) for such Holder and each person, if any, who controls such Holder or underwriter within the meaning of the Securities Act or the Exchange Act, against any losses, claims, damages, or
liabilities (joint or several) to which they may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are
based upon any of the following statements, omissions or violations (collectively a “Violation”) by the Company: (i) any untrue statement or alleged untrue statement of a material fact contained in such registration
statement, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto, (ii) the omission or alleged omission to state therein a material fact required to be stated therein, or necessary to
make the statements therein not misleading, or (iii) any violation or alleged violation by the Company of the Securities Act, the Exchange Act, any state securities law or any rule or regulation promulgated under the Securities Act, the Exchange Act
or any state securities law in connection with the offering covered by such registration statement; and the Company will pay as incurred to each such Holder, partner, officer, director, underwriter or controlling person for any legal or other
expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action; provided however, that the indemnity agreement contained in this Section 2.9(a) shall not apply to amounts paid in
settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the Company, which consent shall not be unreasonably withheld, nor shall the Company be liable in any such case for any such loss,
claim, damage, liability or action to the extent that it arises out of or is based upon a Violation 

  

 10 

 
which occurs in reliance upon and in conformity with written information furnished expressly for use in connection with such registration by such Holder,
partner, officer, director, underwriter or controlling person of such Holder. 
  
 (b) To the extent permitted by law, each Holder will, if Registrable Securities held by such Holder are included in the securities as to which such registration qualifications or compliance is being effected,
indemnify and hold harmless the Company, each of its directors, its officers and each person, if any, who controls the Company within the meaning of the Securities Act, any underwriter and any other Holder selling securities under such registration
statement or any of such other Holder’s partners, directors or officers or any person who controls such Holder, against any losses, claims, damages or liabilities (joint or several) to which the Company or any such director, officer,
controlling person, underwriter or other such Holder, or partner, director, officer or controlling person of such other Holder may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses,
claims, damages or liabilities (or actions in respect thereto) arise out of or are based upon any Violation, in each case to the extent (and only to the extent) that such Violation occurs in reliance upon and in conformity with written information
furnished by such Holder under an instrument duly executed by such Holder and stated to be specifically for use in connection with such registration; and each such Holder will pay as incurred any legal or other expenses reasonably incurred by the
Company or any such director, officer, controlling person, underwriter or other Holder, or partner, officer, director or controlling person of such other Holder in connection with investigating or defending any such loss, claim, damage, liability or
action if it is judicially determined that there was such a Violation; provided, however, that the indemnity agreement contained in this Section 2.9(b) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or
action if such settlement is effected without the consent of the Holder, which consent shall not be unreasonably withheld; provided further, that in no event shall any indemnity under this Section 2.9 exceed the net proceeds from the offering
received by such Holder. 
  
 (c) Promptly after
receipt by an indemnified party under this Section 2.9 of notice of the commencement of any action (including any governmental action), such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under
this Section 2.9, deliver to the indemnifying party a written notice of the commencement thereof and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly with any other
indemnifying party similarly noticed, to assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an indemnified party shall have the right to retain its own counsel, with the fees and expenses to be paid
by the indemnifying party, if representation of such indemnified party by the counsel retained by the indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any other party
represented by such counsel in such proceeding. The failure to deliver written notice to the indemnifying party within a reasonable time of the commencement of any such action, if materially prejudicial to its ability to defend such action, shall
relieve such indemnifying party of any liability to the indemnified party under this Section 2.9, but the omission so to deliver written notice to the indemnifying party will not relieve it of any liability that it may have to any indemnified party
otherwise than under this Section 2.9. 
  
 (d) If
the indemnification provided for in this Section 2.9 is held by a court of competent jurisdiction to be unavailable to an indemnified party with respect to any losses, claims, damages or liabilities referred to herein, the indemnifying party, in
lieu of 

  

 11 

 
indemnifying such indemnified party thereunder, shall to the extent permitted by applicable law contribute to the amount paid or payable by such indemnified
party as a result of such loss, claim, damage or liability in such proportion as is appropriate to reflect the relative fault of the indemnifying party on the one hand and of the indemnified party on the other in connection with the Violation(s)
that resulted in such loss, claim, damage or liability, as well as any other relevant equitable considerations. The relative fault of the indemnifying party and of the indemnified party shall be determined by a court of law by reference to, among
other things, whether the untrue or alleged untrue statement of a material fact or the omission to state a material fact relates to information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent,
knowledge, access to information and opportunity to correct or prevent such statement or omission; provided, that in no event shall any contribution by a Holder hereunder exceed the net proceeds from the offering received by such Holder. 

 
 (e) The obligations of the Company and Holders under this
Section 2.9 shall survive completion of any offering of Registrable Securities in a registration statement and the termination of this Agreement. No indemnifying party, in the defense of any such claim or litigation, shall, except with the consent
of each indemnified party, consent to entry of any judgment or enter into any settlement which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such Indemnified Party of a release from all liability in
respect to such claim or litigation. 
  
 2.10 Assignment of
Registration Rights. The rights to cause the Company to register Registrable Securities pursuant to this Section 2 may be assigned by a Holder to a transferee or assignee of Registrable Securities that (a) is a parent, general partner,
limited partner, retired partner of a Holder that is a partnership, (b) a member or retired member, of a Holder that is a limited liability company, (c) is a Holder’s family member or trust for the benefit of an individual Holder or such
Holder’s family member, (d) is an affiliate of an Investor, or (e) acquires at least 250,000 shares of Registrable Securities (as adjusted for stock splits and combinations); provided, however, (i) the transferor shall, within ten days after
such transfer, furnish to the Company written notice of the name and address of such transferee or assignee and the securities with respect to which such registration rights are being assigned, (ii) such transferee shall agree to be subject to all
restrictions set forth in this Agreement, and (iii) such transfer is in accordance with all applicable securities laws. 
  
 2.11 Amendment of Registration Rights. Any provision of this Section 2 may be amended and the observance thereof may be waived (either generally or
in a particular instance and either retroactively or prospectively), only with the written consent of the Company and the Holders of at least 75% of the Registrable Securities then outstanding. Any amendment or waiver effected in accordance with
this Section 2.11 shall be binding upon each Holder and the Company. By acceptance of any benefits under this Section 2, Holders of Registrable Securities hereby agree to be bound by the provisions hereunder. 
  
 2.12 Limitation on Subsequent Registration Rights. Other than as
provided in Section 5.11, after the date of this Agreement, the Company shall not, without the prior written consent of the Holders of at least 75% of the Registrable Securities then outstanding, enter into any agreement with any holder or
prospective holder of any securities of the Company that would grant such holder registration rights senior to those granted to the Holders hereunder, other than the right to a Special Registration Statement. 
  

 12 

 2.13 “Market Stand-Off” Agreement. Each Holder hereby agrees that such Holder
shall not sell, transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale, any Common Stock (or other securities) of the Company held by such
Holder (other than those included in the registration) for a period specified by the representative of the underwriters of Common Stock (or other securities) of the Company not to exceed 180 days following the effective date of a registration
statement of the Company filed under the Securities Act; provided that all of the Company’s officers, directors and stockholders holding more than 1% of the outstanding shares of Common Stock (including Preferred Stock on an as converted basis)
enter or have entered into similar agreements, and provided that if the Company or underwriters waive or shorten the lock-up period for any of the Company’s officers, directors or stockholders holding more than 1% of the outstanding shares of
Common Stock, then the lock-up for each Holder will also be identically waived or shortened. 
  
 2.14 Agreement to Furnish Information. Each Holder agrees to execute and deliver such other agreements as may be reasonably requested by the Company or the underwriter that are consistent with the Holder’s
obligations under Section 2.13 or that are necessary to give further effect thereto. In addition, if requested by the Company or the representative of the underwriters of Common Stock (or other securities) of the Company, each Holder shall provide,
within ten days of such request, such information as may be required by the Company or such representative in connection with the completion of any public offering of the Company’s securities pursuant to a registration statement filed under the
Securities Act. The obligations described in Section 2.13 and this Section 2.14 shall not apply to a Special Registration. The Company may impose stop-transfer instructions with respect to the shares of Common Stock (or other securities) subject to
the foregoing restriction until the end of said 180 day period. Each Holder agrees that any transferee of any shares of Registrable Securities shall be bound by Sections 2.13 and 2.14. The underwriters of the Company’s stock are intended third
party beneficiaries of Sections 2.13 and 2.14 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. 
  

2.15 Rule 144 Reporting. With a view to making available to the Holders the benefits of certain rules and regulations of the SEC which may
permit the sale of the Registrable Securities to the public without registration, the Company agrees to use its best efforts to: 
  
 (a) Make and keep public information available, as those terms are understood and defined in SEC Rule 144 or any similar or analogous rule
promulgated under the Securities Act, at all times after the effective date of the first registration filed by the Company for an offering of its securities to the general public; 
  
 (b) File with the SEC, in a timely manner, all reports and other documents required of the Company under the
Exchange Act; and 
  
 (c) So long as a Holder
owns any Registrable Securities, furnish to such Holder forthwith upon request: a written statement by the Company as to its compliance with the reporting requirements of said Rule 144 of the Securities Act, and of the Exchange Act (at any time
after it has become subject to such reporting requirements); a copy of the most recent annual or quarterly report of the Company; and such other reports and documents as a 

  

 13 

	 	 
Holder may reasonably request in availing itself of any rule or regulation of the SEC allowing it to sell any such securities without registration.

  
 3. COVENANTS OF THE COMPANY.

  
 3.1 Basic Financial Information and Reporting.

  
 (a) The Company will maintain true books
and records of account in which full and correct entries will be made of all its business transactions pursuant to a system of accounting established and administered in accordance with generally accepted accounting principles consistently applied,
and will set aside on its books all such proper accruals and reserves as shall be required under generally accepted accounting principles consistently applied. 
  

(b) As soon as practicable after the end of each fiscal year of the Company, and in any event within 120 days thereafter, the Company
will furnish each Investor a balance sheet of the Company, as at the end of such fiscal year, and a statement of income and a statement of cash flows of the Company, for such year, all prepared in accordance with generally accepted accounting
principles consistently applied and setting forth in each case in comparative form the figures for the previous fiscal year, all in reasonable detail. Such financial statements shall be accompanied by a report and opinion thereon by independent
public accountants of national standing selected by the Company’s Board of Directors. 
  
 (c) So long as an Investor (with its affiliates) shall own not less than 500,000 shares of Registrable Securities (as adjusted for stock
splits and combinations) (a “Major Investor”), to the extent requested by such Major Investor the Company will furnish each such Major Investor, as soon as practicable (i) after the end of each month, unaudited monthly
financial statements of the Company prepared in accordance with generally accepted accounting principles consistently applied (except as noted thereon), and (ii) after the end of the first, second and third quarterly accounting periods in each
fiscal year of the Company, unaudited quarterly financial statements prepared in accordance with generally accepted accounting principles consistently applied (except as noted thereon). 
  
 3.2 Inspection Rights. Each Major Investor shall have the right to visit and inspect any of the properties of the
Company or any of its subsidiaries, and to discuss the affairs, finances and accounts of the Company or any of its subsidiaries with its officers, and to review such information as is reasonably requested all at such reasonable times and as often as
may be reasonably requested; provided, however, that the Company shall not be obligated under this Section 3.2 with respect to a competitor of the Company or with respect to information which the Board of Directors determines in good faith is
confidential and should not, therefore, be disclosed. 
  
 3.3
Confidentiality of Records. Each Investor agrees to use, and to use its best efforts to insure that its authorized representatives use, the same degree of care as such Investor uses to protect its own confidential information to keep
confidential any information furnished to it which the Company identifies as being confidential or proprietary (so long as such information is not in the public domain), except that such Investor may disclose such proprietary or confidential
information (i) to any partner, subsidiary or parent of such Investor for the purpose of evaluating its investment in the Company as long as such partner, subsidiary or parent is advised of the confidentiality provisions of this Section 3.3; (ii) at
such 

  

 14 

 
time as it enters the public domain through no fault of such Investor; (iii) that is communicated to it free of any obligation of confidentiality by a third
party with rights to do so; or (iv) that is developed by Investor or its agents independently of and without reference to any confidential information communicated by the Company. 
  
 3.4 Reservation of Common Stock. The Company will at all times reserve and keep available, solely for issuance and
delivery upon the conversion of the Preferred Stock, all Common Stock issuable from time to time upon such conversion. 
  
 3.5 Proprietary Information and Inventions Agreement. The Company shall require all employees and consultants to execute and deliver a Proprietary
Information and Inventions Agreement substantially in the form attached to the Purchase Agreement. 
  
 3.6 Stock Vesting. Unless otherwise approved by the Board of Directors, all stock options and other stock equivalents issued after the date
of this Agreement to employees, directors, consultants and other service providers shall be subject to vesting as follows: (a) twenty-five percent (25%) of such stock shall vest at the end of the first year following either the date of issuance or
the date of such person’s services commencement date with the company, and (b) seventy-five percent (75%) of such stock shall vest over the remaining three (3) years. With respect to any shares of stock purchased by any such person, the
Company’s repurchase option shall provide that upon such person’s termination of employment or service with the Company, with or without cause, the Company or its assignee shall have the option to purchase at cost any unvested shares of
stock held by such person. 
  
 3.7 Key Man Insurance. The
Company will use its best efforts to obtain and maintain in full force and effect term life insurance in the amount of two million ($2,000,000) dollars on the lives of each of the Company’s Chief Executive Officer and George Tidmarsh; naming
the Company as beneficiary. 
  
 3.8 Directors’ Liability
and Indemnification; D & O Insurance. The Company’s Certificate of Incorporation and Bylaws shall provide (a) for elimination of the liability of director to the maximum extent permitted by law and (b) for indemnification of directors
for acts on behalf of the Company to the maximum extent permitted by law. The Company will use its best efforts to obtain and maintain in full force and effect directors and officers insurance for each of the directors and officers in the amount of
three million ($3,000,000) dollars or such higher amount that is approved by the Board. 
  
 3.9 Assignment of Right of First Refusal. In the event the Company elects not to exercise any right of first refusal or right of first offer the Company may have on a proposed transfer of any of the
Company’s outstanding capital stock pursuant to the Company’s charter documents, by contract or otherwise, the Company shall, to the extent if may do so, assign such right of first refusal or right of first offer to each Investor. In the
event of such assignment, each Investor shall have a right to purchase its pro rata portion of the capital stock proposed to be transferred. Each Investor’s pro rata portion shall be equal to the product obtained by multiplying (i) the
aggregate number of shares proposed to be transferred by (ii) a fraction, the numerator of which is the number of shares of Registrable Securities held by such Investor at the time of the proposed transfer and the denominator of which is the total
number of Registrable Securities owned by all Investors at the time of such proposed transfer. 
  

 15 

 3.10 Expenses of Non-employee Directors and Board Observers. The reasonable out of pocket expenses
incurred by non-employee directors and permitted observers attending meetings pursuant to rights granted pursuant to Section 3.11, in attending meetings of the Board and other meetings or events on behalf of the Company, shall be reimbursed by the
Company. 
  
 3.11 Visitation Rights. The Company shall
allow one representative designated by any Major Investor not represented by a member of the Board of Directors to attend all meetings of the Company’s Board of Directors in a nonvoting capacity, and in connection therewith, the Company shall
give such representative copies of all notices, minutes, consents and other materials, financial or otherwise, which the Company provides to its Board of Directors; provided, however, that the Company reserves the right to exclude such
representative from access to any material or meeting or portion thereof if the Company believes upon advice of counsel that such exclusion is reasonably necessary to preserve the attorney-client privilege or to protect highly confidential
information or for other similar reasons. The decision of the Board with respect to the privileged or confidential nature of such information shall be final and binding. 
  
 3.12 Restrictions on Operations. The Company shall obtain the approval of the Board of Directors prior to entering
into any business arrangements with a value exceeding $250,000, or such other amount as may be later determined by a majority of the Board of Directors. 
  
 3.13 Termination of Covenants. All covenants of the Company contained in Section 3 of this Agreement (except Sections 3.3, 3.8 and 3.9) shall
expire and terminate as to each Investor upon the earlier of (i) the effective date of the registration statement pertaining to the Initial Offering or (ii) upon (a) the sale, lease or other disposition of all or substantially all of the assets of
the Company or (b) an acquisition of the Company by another corporation or entity by consolidation, merger or other reorganization in which the holders of the Company’s outstanding voting stock immediately prior to such transaction own,
immediately after such transaction, securities representing less than fifty percent (50%) of the voting power of the corporation or other entity surviving such transaction (a “Change in Control”), provided that this Section 3.13(ii)(b)
shall not apply to a merger effected exclusively for the purpose of changing the domicile of the Company. 
  
 4. RIGHTS OF FIRST REFUSAL Subsequent Offerings. Each Major Investor shall have a right of first refusal to purchase its pro rata share of all Equity Securities,
as defined below, that the Company may, from time to time, propose to sell and issue after the date of this Agreement, other than the Equity Securities excluded by Section 4.6 hereof. Each Investor’s pro rata share is equal to the ratio of (a)
the number of shares of the Company’s Common Stock (including all shares of Common Stock issued or issuable upon conversion of the Shares) which such Investor is deemed to be a holder immediately prior to the issuance of such Equity Securities
to (b) the total number of shares of the Company’s outstanding Common Stock (including all shares of Common Stock issued or issuable upon conversion of the Shares or upon the exercise of any outstanding warrants or options) immediately prior to
the issuance of the Equity Securities. The term “Equity Securities” shall mean (i) any Common Stock, Preferred Stock or other security of the Company, (ii) any security convertible, with or without consideration, into any
Common Stock, Preferred Stock or other security (including any option to purchase such a convertible security), (iii) any security 

  

 16 

 
carrying any warrant or right to subscribe to or purchase any Common Stock, Preferred Stock or other security or (iv) any such warrant or right. 

 
 4.2 Exercise of Rights. If the Company proposes to issue any Equity
Securities, it shall give each Major Investor written notice of its intention, describing the Equity Securities, the price and the terms and conditions upon which the Company proposes to issue the same. Each Major Investor shall have 15 days from
the giving of such notice to agree to purchase its pro rata share of the Equity Securities for the price and upon the terms and conditions specified in the notice by giving written notice to the Company and stating therein the quantity of Equity
Securities to be purchased. Notwithstanding the foregoing, the Company shall not be required to offer or sell such Equity Securities to any Major Investor who would cause the Company to be in violation of applicable federal securities laws by virtue
of such offer or sale. 
  
 4.3 Issuance of Equity Securities to
Other Persons. If not all of the Major Investors elect to purchase their pro rata share of the Equity Securities, then the Company shall promptly notify in writing the Major Investors who do so elect and shall offer such Investors the
right to acquire such unsubscribed shares. The Major Investors shall have five (5) days after receipt of such notice to notify the Company of its election to purchase all or a portion thereof of the unsubscribed shares. If the Major Investors fail
to exercise in full the rights of first refusal, the Company shall have 120 days thereafter to sell the Equity Securities in respect of which the Major Investor’s rights were not exercised, at a price and upon general terms and conditions
materially no more favorable to the purchasers thereof than specified in the Company’s notice to the Major Investors pursuant to Section 4.2 hereof. If the Company has not sold such Equity Securities within 90 days of the notice provided
pursuant to Section 4.2, the Company shall not thereafter issue or sell any Equity Securities, without first offering such securities to the Major Investors in the manner provided above. 
  
 4.4 Termination and Waiver of Rights of First Refusal. The rights of first refusal established by this Section 4
shall not apply to, and shall terminate upon the earlier of (i) the effective date of the registration statement pertaining to the Company’s Initial Offering or (ii) a Change in Control. The rights of first refusal established by this Section 4
may be amended, or any provision waived with the written consent of Major Investors holding 75% of the Registrable Securities held by all Major Investors, or as permitted by Section 5.6. 
  
 4.5 Transfer of Rights of First Refusal. The rights of first refusal of each Major Investor under this Section 4 may
be transferred to the same parties, subject to the same restrictions as any transfer of registration rights pursuant to Section 2.10. 
  
 4.6 Excluded Securities. The rights of first refusal established by this Section 4 shall have no application to any of the following Equity
Securities: 
  
 (a) shares of Common Stock and/or
options, warrants or other Common Stock purchase rights and the Common Stock issued pursuant to such options, warrants or other rights issued or to be issued after the Original Issue Date (as defined in the Company’s Certificate of
Incorporation) to employees, officers or directors of, or consultants or advisors to the Company or any subsidiary, pursuant to stock purchase or stock option plans or other arrangements that are approved by the Board of Directors; provided,
however, that such amount shall be increased to reflect any shares of Common Stock (i) not issued pursuant to the rights, agreements, options or warrants outstanding as of the Original Issue Date 

  

 17 

 
(“Outstanding Options”) as a result of the termination of such Outstanding Options or (ii) reacquired by the Company from employees,
directors or consultants at cost pursuant to agreements which permit the Company to repurchase such shares upon termination of services to the Company; 
  
 (b) stock issued or issuable pursuant to any rights or agreements outstanding or approved by the Board of Directors as of the date of this
Agreement, options and warrants outstanding as of the date of this Agreement; and stock issued pursuant to any such rights or agreements granted after the date of this Agreement; provided that the rights of first refusal established by this Section
4 applied with respect to the initial sale or grant by the Company of such rights or agreements; 
  
 (c) any Equity Securities issued for consideration other than cash pursuant to a merger, consolidation, acquisition or similar business
combination approved by the Board of Directors; 
  
 (d) shares of Common Stock issued in connection with any stock split, stock dividend or recapitalization by the Company; 
  
 (e) shares of Common Stock issued upon conversion of shares of the Company’s Preferred Stock; 
  
 (f) any Equity Securities issued pursuant to any equipment
leasing, real property leasing or loan arrangement, or debt financing from a bank or similar financial or lending institution approved by the Board of Directors; 
  
 (g) any Equity Securities issued in connection with strategic transactions involving the Company and other
entities, including (i) strategic alliance, joint ventures, manufacturing, marketing or distribution arrangements or (ii) technology transfer or development arrangements approved by the Board of Directors including the affirmative vote of at least
two (2) representatives designated by the Preferred Stock; and 
  
 (h) any Equity Securities that are issued by the Company pursuant to a registration statement filed under the Securities Act. 
  
 5. MISCELLANEOUS 
  
 5.1 Governing Law. This Agreement shall be governed by and construed under the laws of the State of California as applied to agreements among
California residents entered into and to be performed entirely within California. 
  
 5.2 Survival. The representations, warranties, covenants, and agreements made herein shall survive any investigation made by any Holder and the closing of the transactions contemplated hereby. All statements as
to factual matters contained in any certificate or other instrument delivered by or on behalf of the Company pursuant hereto in connection with the transactions contemplated hereby shall be deemed to be representations and warranties by the Company
hereunder solely as of the date of such certificate or instrument. 
  
 5.3 Successors and Assigns. Except as otherwise expressly provided herein, the provisions hereof shall inure to the benefit of, and be binding upon, the successors, assigns, heirs, executors, and administrators of the parties hereto
and shall inure to the benefit of and 

  

 18 

 
be enforceable by each person who shall be a holder of Registrable Securities from time to time; provided, however, that prior to the receipt by the Company
of adequate written notice of the transfer of any Registrable Securities specifying the full name and address of the transferee, the Company may deem and treat the person listed as the holder of such shares in its records as the absolute owner and
holder of such shares for all purposes, including the payment of dividends or any redemption price. 
  
 5.4 Entire Agreement. This Agreement, the Exhibits and Schedules hereto, the Purchase Agreement and the other documents delivered pursuant thereto
constitute the full and entire understanding and agreement between the parties with regard to the subjects hereof and no party shall be liable or bound to any other in any manner by any representations, warranties, covenants and agreements except as
specifically set forth herein and therein. 
  
 5.5
Severability. In the event one or more of the provisions of this Agreement should, for any reason, be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other
provisions of this Agreement, and this Agreement shall be construed as if such invalid, illegal or unenforceable provision had never been contained herein. 
  
 6. AMENDMENT AND WAIVER 
  
 (a) Except as otherwise expressly provided, this Agreement may be amended or modified only upon the written consent of the Company and the
holders of at least 75% of the Registrable Securities. 
  
 (b) Except as otherwise expressly provided, the obligations of the Company and the rights of the Holders under this Agreement may be waived only with the written consent of the holders of at least 75% of the Registrable Securities.

  
 (c) For the purposes of determining the
number of Holder or Investors entitled to vote or exercise any rights hereunder, the Company shall be entitled to rely solely on the list of record holders of its stock as maintained by or on behalf of the Company, provided that the Company make
reasonably diligent efforts to maintain an accurate updated list of record holders of its stock. 
  
 6.2 Delays or Omissions. 
  
 (a) It is agreed that no delay or omission to exercise any right, power, or remedy accruing to any Holder, upon any breach, default or
noncompliance of the Company under this Agreement shall impair any such right, power, or remedy, nor shall it be construed to be a waiver of any such breach, default or noncompliance, or any acquiescence therein, or of any similar breach, default or
noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent, or approval of any kind or character on any Holder’s part of any breach, default or noncompliance under the Agreement or any waiver on such Holder’s
part of any provisions or conditions of this Agreement must be in writing and shall be effective only to the extent specifically set forth in such writing. All remedies, either under this Agreement, by law, or otherwise afforded to Holders, shall be
cumulative and not alternative. 
  
 (b) It is
agreed that no delay or omission to exercise any right, power, or remedy accruing to the Company, upon any breach, default or noncompliance of the Holder under 

  

 19 

 
this Agreement shall impair any such right, power, or remedy, nor shall it be construed to be a waiver of any such breach, default or noncompliance, or any
acquiescence therein, or of any similar breach, default or noncompliance thereafter occurring. It is further agreed that any waiver, permit, consent, or approval of any kind or character on any Company’s part of any breach, default or
noncompliance under the Agreement or any waiver on such Holder’s part of any provisions or conditions of this Agreement must be in writing and shall be effective only to the extent specifically set forth in such writing. All remedies, either
under this Agreement, by law, or otherwise afforded to Company, shall be cumulative and not alternative 
  
 6.3 Notices. All notices required or permitted hereunder shall be in writing and shall be deemed effectively given: (a) upon personal
delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the recipient; if not, then on the next business day, (c) five days after having been sent by registered or
certified mail, return receipt requested, postage prepaid, or (d) one day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. All communications shall be sent to the party
to be notified at the address as set forth on the signature pages hereof or Exhibit A hereto or at such other address or electronic mail address as such party may designate by ten days advance written notice to the other parties hereto.

  
 6.4 Attorneys’ Fees. In the event that any suit or
action is instituted to enforce any provision in this Agreement, the prevailing party in such dispute shall be entitled to recover from the losing party all fees, costs and expenses of enforcing any right of such prevailing party under or with
respect to this Agreement, including without limitation, such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation, all fees, costs and expenses of appeals. 
  
 6.5 Titles and Subtitles. The titles of the sections and subsections
of this Agreement are for convenience of reference only and are not to be considered in construing this Agreement. 
  
 6.6 Additional Investors. Notwithstanding anything to the contrary contained herein, if the Company shall issue additional shares of its Preferred
Stock pursuant to the Purchase Agreement, any purchaser of such shares of Preferred Stock may become a party to this Agreement by executing and delivering an additional counterpart signature page to this Agreement and shall be deemed an
“Investor,” a “Holder” and a party hereunder. Notwithstanding anything to the contrary contained herein, if the Company shall issue Equity Securities in accordance with Section 4.6 (c), (f) or (h) of
this Agreement, any purchaser of such Equity Securities may become a party to this Agreement by executing and delivering an additional counterpart signature page to this Agreement and shall be deemed an “Investor,” a
“Holder” and a party hereunder. 
  
 6.7
Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be an original, but all of which together shall constitute one instrument. 
  
 6.8 Aggregation of Stock. All shares of Registrable Securities held or acquired by affiliated entities or persons or
persons or entities under common management or control shall be aggregated together for the purpose of determining the availability of any rights under this Agreement. 
  

 20 

 [THIS SPACE INTENTIONALLY LEFT BLANK] 
  

 21 

 In Witness Whereof, the parties hereto have executed this Amended and Restated Investor Rights Agreement
as of the date set forth in the first paragraph hereof. 
  

			
	 COMPANY:

	
	 THRESHOLD PHARMACEUTICALS, INC.

		
	By:	 	 /s/ Harold E. Selick

	 	 	

	 	 	 Harold E. Selick,
 Chief Executive Officer

  

			
	INVESTORS:
	
	 MORGENTHALER PARTNERS VII, L.P.

	By:	 	 Morgenthaler Management Partners VII,
 LLC, Its Managing Partner

		
	By:	 	 /s/ Robert C. Bellas, Jr.

	 	 	

	 	 	 Robert C. Bellas, Jr.,
 Managing Member

  
 AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 
  

			
	INVESTORS:
	
	 CHL MEDICAL PARTNERS II, L.P.

	By:	 	 Collinson Howe & Lennox II, LLC,
 its General Partner

		
	By:	 	 /s/ Ronald W. Lennox

	 	 	

	 Name:
	 	 Ronald W. Lennox

	 Title:
	 	 
	 	 	

	
	 CHL MEDICAL PARTNERS II SIDE FUND, L.P.

	By:	 	 Collinson Howe & Lennox II, LLC,
 its General Partner

		
	By:	 	 /s/ Ronald W. Lennox

	 	 	

	 Name:
	 	 Ronald W. Lennox

	 Title:
	 	 
	 	 	

  
 AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 
  

			
	INVESTORS:
	
	 PEQUOT PRIVATE EQUITY FUND III, L.P.

	By:	 	 Pequot Capital Management, Inc.;
 its Investment Manager

		
	By:	 	 /s/ Richard Joslin

	 	 	

	 	 	 Richard Joslin, Principal

	
	 PEQUOT OFFSHORE PRIVATE EQUITY
 PARTNERS III, L.P.

	By:	 	 Pequot Capital Management, Inc.;
 its Investment Manager

		
	By:	 	 /s/ Richard Joslin

	 	 	

	 	 	 Richard Joslin, Principal

  
 AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 
  

			
	INVESTORS:
	
	 THREE ARCH ASSOCIATES III, L.P.

	By:	 	 Three Arch Management III, L.L.C.
 its General
Partner

		
	By:	 	 /s/ Wilfred Jaeger

	 	 	

	 Name:
	 	 Wilfred Jaeger

	 Title:
	 	 Managing Member

	
	 THREE ARCH PARTNERS III, L.P.

	By:	 	 Three Arch Management III, L.L.C.
 its General
Partner

		
	By:	 	 /s/ Wilfred Jaeger

	 	 	

	 Name:
	 	 Wilfred Jaeger

	 Title:
	 	 Managing Member

  
 AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 
  

			
	INVESTORS:
	
	 SOFINNOVA VENTURE PARTNERS V,
 LP

	By:	 	 Sofinnova Management V, LLC,
 General
Partner

		
	By:	 	 /s/ Mike Powell

	 	 	

	 	 	 Mike Powell,
 Managing Director

	
	SOFINNOVA AFFILIATES V, LP
	By:	 	 Sofinnova Management V, LLC,
 General
Partner

		
	By:	 	 /s/ Mike Powell

	 	 	

	 	 	 Mike Powell
 Managing Director

	
	SOFINNOVA PRINCIPALS FUND V, LP
	By:	 	 Sofinnova Management V, LLC
 General
Partner

		
	By:	 	 /s/ Mike Powell

	 	 	

	 	 	 Mike Powell,
 Managing Director

  
 AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 
  

			
	INVESTORS:
	
	 PROQUEST INVESTMENTS II, L.P.

		
	By:	 	 /s/ Pasquale DeAngelis

	 	 	

	 	 	 Pasquale DeAngelis,
 Chief Financial Officer

	
	PROQUEST INVESTMENTS II ADVISORS
		
	By:	 	 /s/ Pasquale DeAngelis

	 	 	

	 	 	 Pasquale DeAngelis,
 Chief Financial Officer

  
 AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 
  

			
	INVESTORS:
	
	 SUTTER HILL VENTURES,
 A CALIFORNIA LIMITED PARTNERSHIP

		
	By:	 	 /s/ Jeffrey W. Bird

	 	 	

	 Name:
	 	 Jeffrey W. Bird
 Managing Director of the General
 Partner

	
	SUTTER HILL ENTREPRENEURS FUND (AI) L.P.
		
	By:	 	 /s/ Jeffrey W. Bird

	 	 	

	 Name:
	 	 Jeffrey W. Bird
 Managing Director of the General
 Partner

	
	SUTTER HILL ENTREPRENEURS FUND (QP) L.P.
		
	By:	 	 /s/ Jeffrey W. Bird

	 	 	

	 Name:
	 	 Jeffrey W. Bird
 Managing Director of the General
 Partner

	
	 ANVEST, L.P.

		
	By:	 	 /s/ David L. Anderson

	 	 	

	 	 	 David L. Anderson, General Partner

  
 AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 
  

			
	 G. LEONARD BAKER, JR. AND MARY ANNE
 BAKER, CO-TRUSTEES OF THE BAKER
 REVOCABLE TRUST U/A/D 2/3/03

		
	By:	 	 /s/ David E. Sweet - Under Power of Attorney

	 	 	

	 	 	 G. Leonard Baker, Trustee

	
	 SAUNDERS HOLDINGS, L.P.

		
	By:	 	 /s/ David E. Sweet - Under Power of Attorney

	 	 	

	 	 	 G. Leonard Baker, Trustee

	
	 WILLIAM H. YOUNGER, JR., TRUSTEE THE
 YOUNGER LIVING TRUST U/A/D 1/20/95

		
	By:	 	 /s/ William H. Younger, Jr.

	 	 	

	 	 	 William H. Younger, Jr., Trustee

	
	 TENCH COXE AND SIMONE OTUS, CO-
 TRUSTEES OF THE COXE/OTUS
 REVOCABLE TRUST U/A/D 4/23/98

		
	By:	 	 /s/ Tench Coxe

	 	 	

	 	 	 Tench Coxe, Trustee

	
	 GREGORY P. SANDS AND SARAH J.D.
 SANDS AS TRUSTEES OF THE GREGORY P.
 AND SARAH J.D. SANDS TRUST
 AGREEMENT DATED 2/24/99

		
	By:	 	 /s/ Gregory P. Sands

	 	 	

	 	 	 Gregory P. Sands, Trustees

  
 AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 
  

			
	
	 /s/ David E. Sweet - Under Power of Attorney

	

	 James C. Gaither

	
	 JAMES N. WHITE AND PATRICIA A.
 O’BRIEN AS TRUSTEES OF THE WHITE
 FAMILY TRUST U/A/D 4/3/97

		
	 By:
	 	 /s/ James N. White

	 	 	

	 	 	 James N. White, Trustee

	
	 JEFFREY W. BIRD AND CHRISTINA R. BIRD
 AS TRUSTEES OF JEFFREY W. AND
 CHRISTINA R. BIRD TRUST AGREEMENT
 DATED 10/31/00

		
	 By:
	 	 /s/ Jeffery W. Bird

	 	 	

	 	 	 Jeffrey W. Bird, Trustee

	
	 RONALD DANIEL BERNAL AND PAMELA
 MAYER BERNAL AS TRUSTEES OF
 BERNAL FAMILY TRUST U/D/T 11/3/95

		
	 By:
	 	 /s/ David E. Sweet - Under Power of Attorney

	 	 	

	 	 	 Ronald D. Bernal, Trustee

  
 AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 
  

			
	 WELLS FARGO BANK, TRUSTEE
 SHV PROFIT SHARING PLAN FBO
 SHERRYL W. HOSSACK

		
	By:	 	 /s/ Vicki M. Bandel

	 	 	

	 Name:
	 	 Vicki M. Bandel

	 Title:
	 	 Assistant Vice President Trust Officer

	
	 WELLS FARGO BANK, TRUSTEE
 SHV PROFIT SHARING PLAN FBO
 DAVID E. SWEET (ROLLOVER)

		
	By:	 	 /s/ Vicki M. Bandel

	 	 	

	 Name:
	 	 Vicki M. Bandel

	 Title:
	 	 Assistant Vice President Trust Officer

	
	 WELLS FARGO BANK, TRUSTEE
 SHV PROFIT SHARING PLAN FBO
 LYNNE M. BROWN

		
	By:	 	 /s/ Vicki M. Bandel

	 	 	

	 Name:
	 	 Vicki M. Bandel

	 Title:
	 	 Assistant Vice President Trust Officer

  
 AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 
  

			
	 WELLS FARGO BANK, TRUSTEE
 SHV PROFIT SHARING PLAN FBO
 PATRICIA TOM

		
	By:	 	 /s/ Vicki M. Bandel

	 	 	

	 Name:
	 	 Vicki M. Bandel

	 Title:
	 	 Assistant Vice President Trust Officer

	
	 WELLS FARGO BANK, TRUSTEE
 SHV PROFIT SHARING PLAN FBO
 ROBERT YIN

		
	By:	 	 /s/ Vicki M. Bandel

	 	 	

	 Name:
	 	 Vicki M. Bandel

	 Title:
	 	 Assistant Vice President Trust Officer

	
	 WELLS FARGO BANK, TRUSTEE
 SHV PROFIT SHARING PLAN FBO
 DAVID L. ANDERSON

		
	By:	 	 /s/ Vicki M. Bandel

	 	 	

	 Name:
	 	 Vicki M. Bandel

	 Title:
	 	 Assistant Vice President Trust Officer

  
 AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 
  

			
	 WELLS FARGO BANK, TRUSTEE
 SHV PROFIT SHARING PLAN FBO
 JAMES N. WHITE

		
	 By:
	 	 /s/ Vicki M. Bandel

	 	 	

	 Name:
	 	 Vicki M. Bandel

	 Title:
	 	 Assistant Vice President Trust Officer

  
 AMENDED AND
RESTATED INVESTOR RIGHTS AGREEMENT 
 SIGNATURE PAGE 
  

 SCHEDULE OF INVESTORS 
  

					
	 NAME AND ADDRESS

	  	SHARES OF
SERIES B
PREFERRED
STOCK

	  	SHARES OF
SERIES A
PREFERRED
STOCK

			
	 MORGENTHALER PARTNERS VII, L.P.
 2710 Sand Hill Road, Suite 100
 Menlo Park, CA 94025
 Attn: Robert C. Bellas, Jr.
	  	5,454,545	  	 
			
	 CHL MEDICAL PARTNERS II, L.P.
 Collinson Howe & Lennox, LLC
 1055 Washington Boulevard, 6th Floor
 Stamford, CT 06901
 Attn: Ron Lennox
	  	1,703,409	  	 
			
	 CHL MEDICAL PARTNERS II SIDE FUND,
L.P.
 Collinson Howe & Lennox, LLC
 1055 Washington Boulevard, 6th Floor
 Stamford, CT 06901
 Attn: Ron Lennox
	  	114,773	  	 
			
	 PEQUOT PRIVATE EQUITY FUND III,
L.P.
 Pequot Ventures
 500 Nyala Farm Road
 Westport, CT 06880
 Attn: Aryeh Davis and Carlos Rodrigues
	  	4,780,631	  	 
			
	 PEQUOT OFFSHORE PRIVATE EQUITY
PARTNERS III, L.P.
 Pequot Ventures
 500 Nyala Farm Road
 Westport, CT 06880
 Attn: Aryeh Davis and Carlos Rodrigues
	  	673,914	  	 
			
	 THREE ARCH PARTNERS III, L.P.
 3200 Alpine Road
 Portola Valley, CA 94028
 Attn: Barclay Nicholson
	  	2,875,696	  	2,135,250
			
	 THREE ARCH ASSOCIATES III, L.P.
 3200 Alpine Road
 Portola Valley, CA 94028
 Attn: Barclay Nicholson
	  	154,607	  	114,750

  

					
	 NAME AND ADDRESS

	  	SHARES OF
SERIES B
PREFERRED
STOCK

	  	SHARES OF
SERIES A
PREFERRED
STOCK

			
	 SOFINNOVA VENTURE PARTNERS V, LP
 c/o Sofinnova Ventures, Inc.
 140 Geary Street, Tenth Floor
 San Francisco, CA 94018
 Attn: Mike Powell
	  	2,890,866	  	2,146,467
			
	 SOFINNOVA AFFILIATES V, LP
 c/o Sofinnova Ventures, Inc.
 140 Geary Street, Tenth Floor
 San Francisco, CA 94018
 Attn: Mike Powell
	  	95,111	  	70,620
			
	 SOFINNOVA PRINCIPALS FUND V, LP
 c/o Sofinnova Ventures, Inc.
 140 Geary Street, Tenth Floor
 San Francisco, CA 94018
 Attn: Mike Powell
	  	44,326	  	32,913
			
	 PROQUEST INVESTMENTS II, L.P.
 600 Alexander Park, Suite 204
 Princeton, NJ 08540
 Attn: Pasquale DeAngelis
	  	2,908,182	  	2,159,325
			
	 PROQUEST INVESTMENTS II ADVISORS
FUND, L.P.
 600 Alexander Park, Suite 204
 Princeton, NJ 08540
 Attn: Pasquale DeAngelis
	  	122,121	  	90,675
			
	 SUTTER HILL VENTURES, A
CALIFORNIA LIMITED PARTNERSHIP
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	2,066,242	  	1,571,434
			
	 SUTTER HILL ENTREPRENEURS FUND (AI)
L.P.
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	20,932	  	15,542
			
	 SUTTER HILL ENTREPRENEURS FUND (QP)
L.P.
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	53,001	  	39,353

  

 2 

					
	 NAME AND ADDRESS

	  	SHARES OF
SERIES B
PREFERRED
STOCK

	  	SHARES OF
SERIES A
PREFERRED
STOCK

			
	 ANVEST, L.P.
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	36,505	  	27,105
			
	 G. LEONARD BAKER, JR. AND MARY ANNE
BAKER, CO-TRUSTEES OF THE BAKER REVOCABLE TRUST U/A/D 2/3/03
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	67,492	  	37,947
			
	 SAUNDERS HOLDINGS, L.P.
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	51,107	  	37,947
			
	 WILLIAM H. YOUNGER, JR., TRUSTEE
THE YOUNGER LIVING TRUST U/A/D 1/20/95
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	175,227	  	130,106
			
	 TENCH COXE AND SIMONE OTUS,
CO-TRUSTEES OF THE COXE/OTUS LREVOCABLE TRUST
 U/A/D/ 4/23/98
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	248,241	  	184,319
			
	 GREGORY P. SANDS AND SARAH J.D.
SANDS AS TRUSTEES OF GREGORY P. AND SARAH J.D. SANDS
 TRUST AGREEMENT
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	37,055	  	32,526
			
	 JAMES C. GAITHER
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	37,055	  	32,526

  

 3 

					
	 NAME AND ADDRESS

	  	SHARES OF
SERIES B
PREFERRED
STOCK

	  	SHARES OF
SERIES A
PREFERRED
STOCK

			
	 JAMES N. WHITE AND PATRICIA A.
O’BRIEN AS TRUSTEES OF THE WHITE FAMILY TRUST
 U/A/D 4/3/97
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	25,176	  	 
			
	 JEFFREY W. BIRD AND CHRISTINA R.
BIRD AS TRUSTEES OF JEFFREY W. AND CHRISTINA BIRD
 TRUST AGREEMENT DATED 10/31/00
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	34,716	  	22,500
			
	 RONALD DANIEL BERNAL AND
PAMELA MAYER BERNAL AS TRUSTEES OF BERNAL FAMILY TRUST
 U/D/T 11/3/95
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	30,303	  	22,500
			
	 WELLS FARGO BANK, TRUSTEE SHV
PROFIT SHARING PLAN FBO SHERRYL W. HOSSACK
 Attn: Vicki Bandel
 Wells Fargo Bank
 420 Montgomery St, 2nd Floor
 San Francisco, CA 94104
	  	7,576	  	5,625
			
	 WELLS FARGO BANK, TRUSTEE SHV PROFIT SHARING
PLAN FBO DAVID E. SWEET (ROLLOVER)
 Attn: Vicki
Bandel
 Wells Fargo Bank
 420 Montgomery St, 2nd Floor
 San Francisco, CA 94104
	  	30,303	  	11,250
			
	 WELLS FARGO BANK, TRUSTEE SHV
PROFIT SHARING PLAN FBO LYNNE M. BROWN
 Attn: Vicki Bandel
 Wells Fargo Bank
 420 Montgomery St, 2nd Floor
 San Francisco, CA 94104
	  	3,788	  	2,813

  

 4 

					
	 NAME AND ADDRESS

	  	SHARES OF
SERIES B
PREFERRED
STOCK

	  	SHARES OF
SERIES A
PREFERRED
STOCK

			
	 WELLS FARGO BANK, TRUSTEE SHV
PROFIT SHARING PLAN FBO PATRICIA TOM
 Attn: Vicki Bandel
 Wells Fargo Bank
 420 Montgomery St, 2nd Floor
 San Francisco, CA 94104
	  	3,788	  	2,813
			
	 WELLS FARGO BANK, TRUSTEE SHV
PROFIT SHARING PLAN FBO ROBERT YIN
 Attn: Vicki Bandel
 Wells Fargo Bank
 420 Montgomery St, 2nd Floor
 San Francisco, CA 94104
	  	3,788	  	2,813
			
	 WELLS FARGO BANK, TRUSTEE SHV
PROFIT SHARING PLAN FBO DAVID L. ANDERSON
 Attn: Vicki Bandel
 Wells Fargo Bank
 420 Montgomery St, 2nd Floor
 San Francisco, CA 94104
	  	70,288	  	27,105
			
	 WELLS FARGO BANK, TRUSTEE SHV
PROFIT SHARING PLAN FBO JAMES N. WHITE
 Attn: Vicki Bandel
 Wells Fargo Bank
 420 Montgomery St, 2nd Floor
 San Francisco, CA 94104
	  	18,630	  	32,526
			
	 WELLS FARGO BANK, TRUSTEE SHV
PROFIT SHARING PLAN FBO JEFFREY W. BIRD
 Attn: Vicki Bandel
 Wells Fargo Bank
 420 Montgomery St, 2nd Floor
 San Francisco, CA 94104
	  	9,090	  	 
			
	 DAVID E. SWEET
 755 Page Mill Road
 Suite A-200
 Palo Alto, CA 94304
	  	 	  	11,250
			
	 TOTAL:
	  	24,848,484	  	9,000,000

  

 52001 Equity Incentive Plan

 Exhibit 10.1 
  
 THRESHOLD PHARMACEUTICALS, INC. 
  
 2001 EQUITY INCENTIVE PLAN 
  
 Adopted: December 3, 2001 
 Approved
By Stockholders: December 3, 2001 
 Termination Date: December 2, 2011 
 As Amended August 6, 2002 And Approved By Stockholders August 15, 2002 
 As
Amended June 24, 2003 
 As Amended November 14, 2003 
  

	1.	PURPOSES. 

  
 (a) Eligible Stock Award Recipients. The persons eligible to receive Stock Awards are the Employees, Directors and Consultants of the Company and
its Affiliates. 
  
 (b) Available Stock Awards. The purpose
of the Plan is to provide a means by which eligible recipients of Stock Awards may be given an opportunity to benefit from increases in value of the Common Stock through the granting of the following Stock Awards: (i) Incentive Stock Options, (ii)
Nonstatutory Stock Options, (iii) stock bonuses and (iv) rights to acquire restricted stock. 
  
 (c) General Purpose. The Company, by means of the Plan, seeks to retain the services of the group of persons eligible to receive Stock Awards, to secure and retain the services of new members of this group and
to provide incentives for such persons to exert maximum efforts for the success of the Company and its Affiliates. 
  

	2.	DEFINITIONS. 

  
 (a) “Affiliate” means any parent corporation or subsidiary corporation of the Company, whether now or hereafter existing, as those
terms are defined in Sections 424(e) and (f), respectively, of the Code. 
  
 (b) “Board” means the Board of Directors of the Company. 
  
 (c) “Capitalization Adjustment” has the meaning ascribed to that term in Section 
  
 (d) “Change in Control” means the occurrence, in a
single transaction or in a series of related transactions, of any one or more of the following events: 
  
 (i) any Exchange Act Person becomes the Owner, directly or indirectly, of securities of the Company representing more than fifty percent
(50%) of the combined voting power of the Company’s then outstanding securities other than by virtue of a merger, consolidation or similar transaction, provided, however, a Change in Control shall not be deemed to occur solely because the level
of Ownership held by any Exchange Act Person (the “Subject Person”) exceeds the designated percentage threshold of the outstanding voting securities as a 

  

 
result of a repurchase or other acquisition of voting securities by the Company reducing the number of shares outstanding, provided that if a Change in
Control would occur (but for the operation of this sentence) as a result of the acquisition of voting securities by the Company, and after such share acquisition, the Subject Person becomes the Owner of any additional voting securities that,
assuming the repurchase or other acquisition had not occurred, increases the percentage of the then outstanding voting securities Owned by the Subject Person over the designated percentage threshold, then a Change in Control shall be deemed to
occur; 
  
 (ii) there is consummated a merger,
consolidation or similar transaction involving (directly or indirectly) the Company and, immediately after the consummation of such merger, consolidation or similar transaction, the stockholders of the Company immediately prior thereto do not Own,
directly or indirectly, outstanding voting securities representing more than fifty percent (50%) of the combined outstanding voting power of the surviving Entity in such merger, consolidation or similar transaction or more than fifty percent (50%)
of the combined outstanding voting power of the parent of the surviving Entity in such merger, consolidation or similar transaction; 
  
 (iii) the stockholders of the Company approve or the Board approves a plan of complete dissolution or liquidation of the Company, or a
complete dissolution or liquidation of the Company shall otherwise occur; or 
  
 (iv) there is consummated a sale, lease, license or other disposition of all or substantially all of the consolidated assets of the Company and its Subsidiaries, other than a sale, lease, license or other disposition
of all or substantially all of the consolidated assets of the Company and its Subsidiaries to an Entity, more than fifty percent (50%) of the combined voting power of the voting securities of which are Owned by stockholders of the Company in
substantially the same proportions as their Ownership of the Company immediately prior to such sale, lease, license or other disposition. 
  
 Notwithstanding the foregoing or any other provision of this Plan, the definition of Change in Control (or any analogous term) in an individual written
agreement between the Company or any Affiliate and the Participant shall supersede the foregoing definition with respect to Stock Awards subject to such agreement (it being understood, however, that if no definition of Change in Control or any
analogous term is set forth in such an individual written agreement, the foregoing definition shall apply). 
  
 (e) “Code” means the Internal Revenue Code of 1986, as amended. 
  
 (f) “Committee” means a committee of one or more members of the Board appointed by the Board in
accordance with Section 3(c). 
  
 (g) “Common
Stock” means the common stock of the Company. 
  
 (h)
“Company” means Threshold Pharmaceuticals, Inc., a Delaware corporation. 
  
 (i) “Consultant” means any person, including an advisor, (i) engaged by the Company or an Affiliate to render consulting or
advisory services and who is compensated for such services or (ii) serving as a member of the Board of Directors of an Affiliate and who is 

  

 2 

 
compensated for such services, However, the term “Consultant” shall not include Directors who are not compensated by the Company for their services
as Directors, and the payment of a director’s fee by the Company for services as a Director shall not cause a Director to be considered a “Consultant” for purposes of the Plan. 
  
 (j) “Continuous Service” means that the
Participant’s service with the Company or an Affiliate, whether as an Employee, Director or Consultant, is not interrupted or terminated. A change in the capacity in which the Participant renders service to the Company or an Affiliate as an
Employee, Consultant or Director or a change in the entity for which the Participant renders such service, provided that there is no interruption or termination of the Participant’s service with the Company or an Affiliate, shall not terminate
a Participant’s Continuous Service. For example, a change in status from an Employee of the Company to a Consultant of an Affiliate or a Director shall not constitute an interruption of Continuous Service. The Board or the chief executive
officer of the Company, in that party’s sole discretion, may determine whether Continuous Service shall be considered interrupted in the case of any leave of absence approved by that party, including sick leave, military leave or any other
personal leave. Notwithstanding the foregoing, a leave of absence shall be treated as Continuous Service for purposes of vesting in a Stock Award only to such extent as may be provided in the Company’s leave of absence policy or in the written
terms of the Participant’s leave of absence. 
  
 (k)
“Corporate Transaction” means the occurrence, in a single transaction or in a series of related transactions, of any one or more of the following events: 
  
 (i) a sale or other disposition of all or substantially all, as determined by the Board in its discretion,
of the consolidated assets of the Company and its Subsidiaries; 
  
 (ii) a sale or other disposition of at least fifty percent (50%) of the outstanding securities of the Company; 
  
 (iii) a merger, consolidation or similar transaction following which the Company is not the surviving corporation; or 
  
 (iv) a merger, consolidation or similar transaction
following which the Company is the surviving corporation but the shares of Common Stock outstanding immediately preceding the merger, consolidation or similar transaction are converted or exchanged by virtue of the merger, consolidation or similar
transaction into other property, whether in the form of securities, cash or otherwise. 
  
 (l) “Director” means a member of the Board of Directors of the Company. 
  
 (m) “Disability” means the inability of a person, in the opinion of a qualified physician acceptable to the Company, to perform
the major duties of that person’s position with the Company or an Affiliate because of the sickness or injury of the person. 
  
 (n) “Employee” means any person employed by the Company or an Affiliate. Service as a Director or payment of a director’s fee
by the Company or an Affiliate shall not be sufficient to constitute “employment” by the Company or an Affiliate. 
  

 3 

 (o) “Entity” means a corporation, partnership or other entity. 
  
 (p) “Exchange Act” means the Securities Exchange Act
of 1934, as amended. 
  
 (q) “Exchange Act Person”
means any natural person, Entity or “group” (within the meaning of Section 13(d) or 14(d) of the Exchange Act), except that “Exchange Act Person” shall not include (A) the Company or any Subsidiary of the Company, (B) any
employee benefit plan of the Company or any Subsidiary of the Company or any trustee or other fiduciary holding securities under an employee benefit plan of the Company or any Subsidiary of the Company, (C) an underwriter temporarily holding
securities pursuant to an offering of such securities, or (D) an Entity Owned, directly or indirectly, by the stockholders of the Company in substantially the same proportions as their Ownership of stock of the Company. 
  
 (r) “Fair Market Value” means, as of any date, the
value of the Common Stock determined in good faith by the Board, and in a manner consistent with Section 260.140.50 of Title 10 of the California Code of Regulations. 
  
 (s) “Incentive Stock Option” means an Option intended to qualify as an incentive stock option within
the meaning of Section 422 of the Code and the regulations promulgated thereunder. 
  
 (t) “Nonstatutory Stock Option” means an Option not intended to qualify as an Incentive Stock Option. 
  
 (u) “Officer” means any person designated by the Company as an officer. 
  
 (v) “Option” means an Incentive Stock Option or a
Nonstatutory Stock Option granted pursuant to the Plan. 
  
 (w)
“Option Agreement” means a written agreement between the Company and an Optionholder evidencing the terms and conditions of an individual Option grant. Each Option Agreement shall be subject to the terms and conditions of the
Plan. 
  
 (x) “Optionholder” means a
person to whom an Option is granted pursuant to the Plan or, if applicable, such other person who holds an outstanding Option. 
  
 (y) “Own,” “Owned,” “Owner,” “Ownership” A person or Entity shall be deemed to “Own,” to
have “Owned,” to be the “Owner” of, or to have acquired “Ownership” of securities if such person or Entity, directly or indirectly, through any contract, arrangement, understanding, relationship or otherwise, has or
shares voting power, which includes the power to vote or to direct the voting, with respect to such securities. 
  
 (z) “Participant” means a person to whom a Stock Award is granted pursuant to the Plan or, if applicable, such other person who
holds an outstanding Stock Award. 
  
 (aa)
“Plan” means this Threshold Pharmaceuticals, Inc. 2001 Equity Incentive Plan. 
  
 (bb) “Securities Act” means the Securities Act of 1933, as amended. 
  

 4 

 (cc) “Stock Award” means any right granted under the Plan, including an Option, a
stock bonus and a right to acquire restricted stock. 
  
 (dd)
“Stock Award Agreement” means a written agreement between the Company and a holder of a Stock Award evidencing the terms and conditions of an individual Stock Award grant. Each Stock Award Agreement shall be subject to the
terms and conditions of the Plan. 
  
 (ee)
“Subsidiary” means, with respect to the Company, (i) any corporation of which more than fifty percent (50%) of the outstanding capital stock having ordinary voting power to elect a majority of the board of directors of such
corporation (irrespective of whether, at the time, stock of any other class or classes of such corporation shall have or might have voting power by reason of the happening of any contingency) is at the time, directly or indirectly, Owned by the
Company, and (ii) any partnership in which the Company has a direct or indirect interest (whether in the form of voting or participation in profits or capital contribution) of more than fifty percent (50%). 
  
 (ff) “Ten Percent Stockholder” means a person who
Owns (or is deemed to Own pursuant to Section 424(d) of the Code) stock possessing more than ten percent (10%) of the total combined voting power of all classes of stock of the Company or of any of its Affiliates. 
  

	3.	ADMINISTRATION. 

  
 (a) Administration by Board. The Board shall administer the Plan unless and until the Board delegates administration to a Committee, as provided in
Section 3(c). 
  
 (b) Powers of Board. The Board shall have
the power, subject to, and within the limitations of, the express provisions of the Plan: 
  
 (i) To determine from time to time which of the persons eligible under the Plan shall be granted Stock Awards; when and how each Stock
Award shall be granted; what type or combination of types of Stock Award shall be granted; the provisions of each Stock Award granted (which need not be identical), including the time or times when a person shall be permitted to receive Common Stock
pursuant to a Stock Award; and the number of shares of Common Stock with respect to which a Stock Award shall be granted to each such person. 
  
 (ii) To construe and interpret the Plan and Stock Awards granted under it, and to establish, amend and revoke rules and regulations for
its administration. The Board, in the exercise of this power, may correct any defect, omission or inconsistency in the Plan or in any Stock Award Agreement, in a manner and to the extent it shall deem necessary or expedient to make the Plan fully
effective. 
  
 (iii) To amend the Plan or a Stock
Award as provided in Section 12. 
  
 (iv) To
terminate or suspend the Plan as provided in Section 13. 
  
 (v) Generally, to exercise such powers and to perform such acts as the Board deems necessary or expedient to promote the best interests of the Company and that are not in conflict with the provisions of the Plan.

  

 5 

 (c) Delegation to Committee. The Board may delegate administration of the Plan to a Committee or
Committees of one (1) or more members of the Board, and the term “Committee” shall apply to any person or persons to whom such authority has been delegated. If administration is delegated to a Committee, the Committee shall have, in
connection with the administration of the Plan, the powers theretofore possessed by the Board, including the power to delegate to a subcommittee any of the administrative powers the Committee is authorized to exercise (and references in this Plan to
the Board shall thereafter be to the Committee or subcommittee), subject, however, to such resolutions, not inconsistent with the provisions of the Plan, as may be adopted from time to time by the Board. The Board may abolish the Committee at any
time and revest in the Board the administration of the Plan. 
  
 (d) Delegation to an Officer. The Board may delegate to one or more Officers of the Company the authority to do one or both of the following: (i) designate Officers and Employees of the Company or any of its Subsidiaries to be
recipients of Stock Awards and (ii) determine the number of shares of Common Stock to be subject to such Stock Awards granted to such Officers and Employees of the Company; provided, however, that the Board resolutions regarding such delegation
shall specify the total number of shares of Common Stock that may be subject to the Stock Awards granted by such Officer and that such Officer may not grant a Stock Award to himself or herself. Notwithstanding the foregoing, the Board may not
delegate authority to an Officer to determine the Fair Market Value of the Common Stock. 
  
 (e) Effect of Board’s Decision. All determinations, interpretations and constructions made by the Board in good faith shall not be subject to review by any person and shall be final, binding and conclusive
on all persons. 
  

	4.	SHARES SUBJECT TO THE PLAN. 

  
 (a) Share Reserve. Subject to the provisions of Section 11(a) relating to Capitalization Adjustments, the Common Stock that may be issued pursuant
to Stock Awards shall not exceed in the aggregate seven million (7,000,000) post-split shares of Common Stock. 
  
 (b) Reversion of Shares to the Share Reserve. If any Stock Award shall for any reason expire or otherwise terminate, in whole or in part, without
having been exercised in full, or if any shares of Common Stock issued to a Participant pursuant to a Stock Award are forfeited back to or repurchased by the Company because of or in connection with the failure to meet a contingency or condition
required to vest such shares in the Participant, the shares of Common Stock not acquired, forfeited or repurchased under such Stock Award shall revert to and again become available for issuance under the Plan; provided, however, that subject to the
provisions of Section II (a) relating to Capitalization Adjustments, the aggregate maximum number of shares of Common Stock that may be issued as Incentive Stock Options shall be seven million (7,000,000) post-split shares of Common Stock.

  
 (c) Source of Shares. The shares of Common Stock
subject to the Plan may be unissued shares or reacquired shares, bought on the market or otherwise. 
  
 (d) Share Reserve Limitation. To the extent required by Section 260.140.45 of Title 10 of the California Code of Regulations, the total number of
shares of Common Stock issuable 

  

 6 

 
upon exercise of all outstanding Options and the total number of shares of Common Stock provided for under any stock bonus or similar plan of the Company
shall not exceed the applicable percentage as calculated in accordance with the conditions and exclusions of Section 260.140.45 of Title 10 of the California Code of Regulations, based on the shares of Common Stock of the Company that are
outstanding at the time the calculation is made. 
  

	5.	ELIGIBILITY. 

  
 (a) Eligibility for Specific Stock Awards. Incentive Stock Options may be granted only to Employees. Stock Awards other than Incentive Stock
Options may be granted to Employees, Directors and Consultants. 
  
 (b) Ten Percent Stockholders. 
  
 (i) A Ten Percent Stockholder shall not be granted an Incentive Stock Option unless the exercise price of such Option is at least one hundred ten percent (I 10%) of the Fair Market Value of the Common Stock on the date of grant and the
Option is not exercisable after the expiration of five (5) years from the date of grant. 
  
 (ii) A Ten Percent Stockholder shall not be granted a Nonstatutory Stock Option unless the exercise price of such Option is at least (i)
one hundred ten percent (110%) of the Fair Market Value of the Common Stock on the date of grant or (ii) such lower percentage of the Fair Market Value of the Common Stock on the date of grant as is permitted by Section 260.140.41 of Title 10 of the
California Code of Regulations at the time of the grant of the Option. 
  
 (iii) A Ten Percent Stockholder shall not be granted a restricted stock award unless the purchase price of the restricted stock is at least (i) one hundred percent (100%) of the Fair Market Value of the Common Stock
on the date of grant or (ii) such lower percentage of the Fair Market Value of the Common Stock on the date of grant as is permitted by Section 260.140.41 of Title 10 of the California Code of Regulations at the time of the grant of the restricted
stock award. 
  
 (c) Consultants. A Consultant shall not be
eligible for the grant of a Stock Award if, at the time of grant, either the offer or the sale of the Company’s securities to such Consultant is not exempt under Rule 701 of the Securities Act (“Rule 701”) because of the nature of the
services that the Consultant is providing to the Company, because the Consultant is not a natural person, or because of some other provision of Rule 701, unless the Company determines that such grant need not comply with the requirements of Rule 701
and will satisfy another exemption under the Securities Act as well as comply with the securities laws of all other relevant jurisdictions. 
  

	6.	OPTION PROVISIONS. 

  
 Each Option shall be in such form and shall contain such terms and conditions as the Board shall deem appropriate. All Options shall be separately
designated Incentive Stock Options or Nonstatutory Stock Options at the time of grant, and, if certificates are issued, a separate certificate or certificates shall be issued for shares of Common Stock purchased on 

  

 7 

 
exercise of each type of Option. The provisions of separate Options need not be identical, but each Option shall include (through incorporation of provisions
hereof by reference in the Option or otherwise) the substance of each of the following provisions: 
  
 (a) Term. Subject to the provisions of Section 5(b) regarding Ten Percent Stockholders, no Option shall be exercisable after the expiration of ten
(10) years from the date it was granted. 
  
 (b) Exercise Price
of an Incentive Stock Option. Subject to the provisions of Section 5(b) regarding Ten Percent Stockholders, the exercise price of each Incentive Stock Option shall be not less than one hundred percent (100%) of the Fair Market Value of the
Common Stock subject to the Option on the date the Option is granted. Notwithstanding the foregoing, an Incentive Stock Option may be granted with an exercise price lower than that set forth in the preceding sentence if such Option is granted
pursuant to an assumption or substitution for another option in a manner satisfying the provisions of Section 424(a) of the Code. 
  
 (c) Exercise Price of a Nonstatutory Stock Option. Subject to the provisions of Section 5(b) regarding Ten Percent Stockholders, the exercise price
of each Nonstatutory Stock Option shall be not less than eighty-five percent (85%) of the Fair Market Value of the Common Stock subject to the Option on the date the Option is granted. Notwithstanding the foregoing, a Nonstatutory Stock Option may
be granted with an exercise price lower than that set forth in the preceding sentence if such Option is granted pursuant to an assumption or substitution for another option in a manner satisfying the provisions of Section 424(a) of the Code.

  
 (d) Consideration. The purchase price of Common Stock
acquired pursuant to an Option shall be paid, to the extent permitted by applicable statutes and regulations, either (i) in cash at the time the Option is exercised or (ii) at the discretion of the Board at the time of the grant of the Option (or
subsequently in the case of a Nonstatutory Stock Option) (1) by delivery to the Company of other Common Stock, (2) according to a deferred payment or other similar arrangement with the Optionholder or (3) in any other form of legal consideration
that may be acceptable to the Board. Unless otherwise specifically provided in the Option, the purchase price of Common Stock acquired pursuant to an Option that is paid by delivery to the Company of other Common Stock acquired, directly or
indirectly from the Company, shall be paid only by shares of the Common Stock of the Company that have been held for more than six (6) months (or such longer or shorter period of time required to avoid a charge to earnings for financial accounting
purposes). At any time that the Company is incorporated in Delaware, payment of the Common Stock’s “par value,” as defined in the Delaware General Corporation Law, shall not be made by deferred payment. 
  
 In the case of any deferred payment arrangement, interest shall be compounded
at least annually and shall be charged at the minimum rate of interest necessary to avoid (1) the treatment as interest, under any applicable provisions of the Code, of any amounts other than amounts stated to be interest under the deferred payment
arrangement and (2) the treatment of the Option as a variable award for financial accounting purposes. 
  

 8 

 (e) Transferability of an Incentive Stock Option. An Incentive Stock Option shall not be
transferable except by will or by the laws of descent and distribution and shall be exercisable during the lifetime of the Optionholder only by the Optionholder. Notwithstanding the foregoing, the Optionholder may, by delivering written notice to
the Company, in a form satisfactory to the Company, designate a third party who, in the event of the death of the Optionholder, shall thereafter be entitled to exercise the Option. 
  
 (f) Transferability of a Nonstatutory Stock Option. A Nonstatutory Stock Option shall not be transferable except by
will or by the laws of descent and distribution and, to the extent provided in the Option Agreement, to such further extent as permitted by Section 260.140.41 (d) of Title 10 of the California Code of Regulations at the time of the grant of the
Option, and shall be exercisable during the lifetime of the Optionholder only by the Optionholder. If the Nonstatutory Stock Option does not provide for transferability, then the Nonstatutory Stock Option shall not be transferable except by will or
by the laws of descent and distribution and shall be exercisable during the lifetime of the Optionholder only by the Optionholder. Notwithstanding the foregoing, the Optionholder may, by delivering written notice to the Company, in a form
satisfactory to the Company, designate a third party who, in the event of the death of the Optionholder, shall thereafter be entitled to exercise the Option. 
  
 (g) Vesting Generally. The total number of shares of Common Stock subject to an Option may, but need not, vest and therefore become exercisable in
periodic installments that may, but need not, be equal. The Option may be subject to such other terms and conditions on the time or times when it may be exercised (which may be based on performance or other criteria) as the Board may deem
appropriate. The vesting provisions of individual Options may vary. The provisions of this Section 6(g) are subject to any Option provisions governing the minimum number of shares of Common Stock as to which an Option may be exercised. 

 
 (h) Minimum Vesting. Notwithstanding the foregoing Section 6(g), to
the extent that the following restrictions on vesting are required by Section 260.140.41 (f) of Title 10 of the California Code of Regulations at the time of the grant of the Option, then: 
  
 (i) Options granted to an Employee who is not an Officer,
Director or Consultant shall provide for vesting of the total number of shares of Common Stock at a rate of at least twenty percent (20%) per year over five (5) years from the date the Option was granted, subject to reasonable conditions such as
continued employment; and 
  
 (ii) Options
granted to Officers, Directors or Consultants may be made fully exercisable, subject to reasonable conditions such as continued employment, at any time or during any period established by the Company. 
  
 (i) Termination of Continuous Service. In the event that an
Optionholder’s Continuous Service terminates (other than upon the Optionholder’s death or Disability), the Optionholder may exercise his or her Option (to the extent that the Optionholder was entitled to exercise such Option as of the date
of termination) but only within such period of time ending on the earlier of (i) the date three (3) months following the termination of the Optionholder’s Continuous Service (or such longer or shorter period specified in the Option Agreement,
which period shall not be less than thirty (30) days unless such termination is for cause), or (ii) the 

  

 9 

 
expiration of the term of the Option as set forth in the Option Agreement. If, after termination, the Optionholder does not exercise his or her Option within
the time specified in the Option Agreement, the Option shall terminate. 
  
 (j) Extension of Termination Date. An Optionholder’s Option Agreement may also provide that if the exercise of the Option following the termination of the Optionholder’s Continuous Service (other than upon the
Optionholder’s death or Disability) would be prohibited at any time solely because the issuance of shares of Common Stock would violate the registration requirements under the Securities Act, then the Option shall terminate on the earlier of
(1) the expiration of the term of the Option set forth in Section 6(a) or (ii) the expiration of a period of three (3) months after the termination of the Optionholder’s Continuous Service during which the exercise of the Option would not be in
violation of such registration requirements. 
  
 (k) Disability
of Optionholder. In the event that an Optionholder’s Continuous Service terminates as a result of the Optionholder’s Disability, the Optionholder may exercise his or her Option (to the extent that the Optionholder was entitled to
exercise such Option as of the date of termination), but only within such period of time ending on the earlier of (i) the date twelve (12) months following such termination (or such longer or shorter period specified in the Option Agreement, which
period shall not be less than six (6) months) or (ii) the expiration of the term of the Option as set forth in the Option Agreement. If, after termination, the Optionholder does not exercise his or her Option within the time specified herein, the
Option shall terminate. 
  
 (l) Death of Optionholder. In
the event that (i) an Optionholder’s Continuous Service terminates as a result of the Optionholder’s death or (ii) the Optionholder dies within the period (if any) specified in the Option Agreement after the termination of the
Optionholder’s Continuous Service for a reason other than death, then the Option may be exercised (to the extent the Optionholder was entitled to exercise such Option as of the date of death) by the Optionholder’s estate, by a person who
acquired the right to exercise the Option by bequest or inheritance or by a person designated to exercise the option upon the Optionholder’s death pursuant to Section 6(e) or 6(f), but only within the period ending on the earlier of (1) the
date eighteen (18) months following the date of death (or such longer or shorter period specified in the Option Agreement, which period shall not be less than six (6) months) or (2) the expiration of the term of such Option as set forth in the
Option Agreement. If, after death, the Option is not exercised within the time specified herein, the Option shall terminate. 
  
 (m) Early Exercise. The Option may, but need not, include a provision whereby the Optionholder may elect at any time before the Optionholder’s
Continuous Service terminates to exercise the Option as to any part or all of the shares of Common Stock subject to the Option prior to the full vesting of the Option. Subject to the “Repurchase Limitation” in Section 10(h), any unvested
shares of Common Stock so purchased may be subject to a repurchase option in favor of the Company or to any other restriction the Board determines to be appropriate. Provided that the “Repurchase Limitation” in Section I 0(h) is not
violated, the Company will not exercise its repurchase option until at least six (6) months (or such longer or shorter period of time required to avoid a charge to earnings for financial accounting purposes) have elapsed following exercise of the
Option unless the Board otherwise specifically provides in the Option. 
  

 10 

 (n) Right of Repurchase. Subject to the “Repurchase Limitation” in Section 10(h), the
Option may, but need not, include a provision whereby the Company may elect to repurchase all or any part of the vested shares of Common Stock acquired by the Optionholder pursuant to the exercise of the Option. Provided that the “Repurchase
Limitation” in Section 10(h) is not violated, the Company will not exercise its repurchase option until at least six (6) months (or such longer or shorter period of time required to avoid a charge to earnings for financial accounting purposes)
have elapsed following exercise of the Option unless the Board otherwise specifically provides in the Option. 
  
 (o) Right of First Refusal. The Option may, but need not, include a provision whereby the Company may elect to exercise a right of first refusal
following receipt of notice from the Optionholder of the intent to transfer all or any part of the shares of Common Stock received upon the exercise of the Option. Except as expressly provided in this Section 6(o), such right of first refusal shall
otherwise comply with any applicable provisions of the Bylaws of the Company. 
  

	7.	PROVISIONS OF STOCK AWARDS OTHER THAN OPTIONS. 

  
 (a) Stock Bonus Awards. Each stock bonus agreement shall be in such form and shall contain such terms and conditions as the Board shall deem
appropriate. The terms and conditions of stock bonus agreements may change from time to time, and the terms and conditions of separate stock bonus agreements need not be identical, but each stock bonus agreement shall include (through incorporation
of provisions hereof by reference in the agreement or otherwise) the substance of each of the following provisions: 
  
 (i) Consideration. A stock bonus may be awarded in consideration for past services actually rendered to the Company or an Affiliate
for its benefit. 
  
 (ii) Vesting. Subject
to the “Repurchase Limitation” in Section 10(h), shares of Common Stock awarded under the stock bonus agreement may, but need not, be subject to a share repurchase option in favor of the Company in accordance with a vesting schedule to be
determined by the Board. 
  
 (iii) Termination
of Participant’s Continuous Service. Subject to the “Repurchase Limitation” in Section 10(h), in the event that a Participant’s Continuous Service terminates, the Company may reacquire any or all of the shares of Common Stock
held by the Participant that have not vested as of the date of termination under the terms of the stock bonus agreement. 
  
 (iv) Transferability. Rights to acquire shares of Common Stock under the stock bonus agreement shall not be transferable except by
will or by the laws of descent and distribution and shall be exercisable during the lifetime of the Participant only by the Participant. 
  
 (b) Restricted Stock Awards. Each restricted stock purchase agreement shall be in such form and shall contain such terms and conditions as the
Board shall deem appropriate. The terms and conditions of the restricted stock purchase agreements may change from time to time, and the terms and conditions of separate restricted stock purchase agreements need not be identical, but each restricted
stock purchase agreement shall include (through incorporation of 

  

 11 

 
provisions hereof by reference in the agreement or otherwise) the substance of each of the following provisions: 
  
 (i) Purchase Price. Subject to the provisions of
Section 5(b) regarding Ten Percent Stockholders, the purchase price of restricted stock awards shall not be less than eighty-five percent (85%) of the Common Stock’s Fair Market Value on the date such award is made or at the time the purchase
is consummated. 
  
 (ii) Consideration.
The purchase price of Common Stock acquired pursuant to the restricted stock purchase agreement shall be paid either: (i) in cash at the time of purchase; (ii) at the discretion of the Board, according to a deferred payment or other similar
arrangement with the Participant; or (iii) in any other form of legal consideration that may be acceptable to the Board in its discretion; provided, however, that at any time that the Company is incorporated in Delaware, then payment of the Common
Stock’s “par value,” as defined in the Delaware General Corporation Law, shall not be made by deferred payment. 
  
 (iii) Vesting. Subject to the “Repurchase Limitation” in Section 10(h), shares of Common Stock acquired under the
restricted stock purchase agreement may, but need not, be subject to a share repurchase option in favor of the Company in accordance with a vesting schedule to be determined by the Board. 
  
 (iv) Termination of Participant’s Continuous
Service. Subject to the “Repurchase Limitation” in Section 10(h), in the event that a Participant’s Continuous Service terminates, the Company may repurchase or otherwise reacquire any or all of the shares of Common Stock held by
the Participant that have not vested as of the date of termination under the terms of the restricted stock purchase agreement. 
  
 (v) Transferability. Rights to acquire shares of Common Stock under the restricted stock purchase agreement shall not be
transferable except by will or by the laws of descent and distribution and shall be exercisable during the lifetime of the Participant only by the Participant. 
  

	8.	COVENANTS OF THE COMPANY. 

  
 (a) Availability of Shares. During the terms of the Stock Awards, the Company shall keep available at all times the number of shares of Common
Stock required to satisfy such Stock Awards. 
  
 (b) Securities
Law Compliance. The Company shall seek to obtain from each regulatory commission or agency having jurisdiction over the Plan such authority as may be required to grant Stock Awards and to issue and sell shares of Common Stock upon exercise of
the Stock Awards; provided, however, that this undertaking shall not require the Company to register under the Securities Act the Plan, any Stock Award or any Common Stock issued or issuable pursuant to any such Stock Award. If, after reasonable
efforts, the Company is unable to obtain from any such regulatory commission or agency the authority which counsel for the Company deems necessary for the lawful issuance and sale of Common Stock under the Plan, the Company shall be relieved from
any liability for failure to issue and sell Common Stock upon exercise of such Stock Awards unless and until such authority is obtained. 
  

 12 

	9.	USE OF PROCEEDS FROM STOCK. 

  
 Proceeds from the sale of Common Stock pursuant to Stock Awards shall constitute general funds of the Company. 
  

	10.	MISCELLANEOUS. 

  
 (a) Acceleration of Exercisability and Vesting. The Board shall have the power to accelerate the time at which a Stock Award may first be exercised
or the time during which a Stock Award or any part thereof will vest in accordance with the Plan, notwithstanding the provisions in the Stock Award stating the time at which it may first be exercised or the time during which it will vest.

  
 (b) Stockholder Rights. No Participant shall be deemed
to be the holder of, or to have any of the rights of a holder with respect to, any shares of Common Stock subject to such Stock Award unless and until such Participant has satisfied all requirements for exercise of the Stock Award pursuant to its
terms. 
  
 (c) No Employment or other Service Rights.
Nothing in the Plan or any instrument executed or Stock Award granted pursuant thereto shall confer upon any Participant any right to continue to serve the Company or an Affiliate in the capacity in effect at the time the Stock Award was granted or
shall affect the right of the Company or an Affiliate to terminate (i) the employment of an Employee with or without notice and with or without cause, (ii) the service of a Consultant pursuant to the terms of such Consultant’s agreement with
the Company or an Affiliate or (iii) the service of a Director pursuant to the Bylaws of the Company or an Affiliate, and any applicable provisions of the corporate law of the state in which the Company or the Affiliate is incorporated, as the case
may be. 
  
 (d) Incentive Stock Option $100,000 Limitation.
To the extent that the aggregate Fair Market Value (determined at the time of grant) of Common Stock with respect to which Incentive Stock Options are exercisable for the first time by any Optionholder during any calendar year (under all plans of
the Company and its Affiliates) exceeds one hundred thousand dollars ($100,000), the Options or portions thereof that exceed such limit (according to the order in which they were granted) shall be treated as Nonstatutory Stock Options,
notwithstanding any contrary provision of an Stock Award Agreement. 
  
 (e) Investment Assurances. The Company may require a Participant, as a condition of exercising or acquiring Common Stock under any Stock Award, (i) to give written assurances satisfactory to the Company as to the Participant’s
knowledge and experience in financial and business matters and/or to employ a purchaser representative reasonably satisfactory to the Company who is knowledgeable and experienced in financial and business matters and that he or she is capable of
evaluating, alone or together with the purchaser representative, the merits and risks of exercising the Stock Award; and (ii) to give written assurances satisfactory to the Company stating that the Participant is acquiring Common Stock subject to
the Stock Award for the Participant’s own account and not with any present intention of selling or otherwise distributing the Common Stock. The foregoing requirements, and any assurances given pursuant to such requirements, shall be inoperative
if (1) the issuance of the shares of Common Stock 

  

 13 

 
upon the exercise or acquisition of Common Stock under the Stock Award has been registered under a then currently effective registration statement under the
Securities Act or (2) as to any particular requirement, a determination is made by counsel for the Company that such requirement need not be met in the circumstances under the then applicable securities laws. The Company may, upon advice of counsel
to the Company, place legends on stock certificates issued under the Plan as such counsel deems necessary or appropriate in order to comply with applicable securities laws, including, but not limited to, legends restricting the transfer of the
Common Stock. 
  
 (f) Withholding Obligations. To the
extent provided by the terms of a Stock Award Agreement, the Participant may satisfy any federal, state or local tax withholding obligation relating to the exercise or acquisition of Common Stock under a Stock Award by any of the following means (in
addition to the Company’s right to withhold from any compensation paid to the Participant by the Company) or by a combination of such means: (i) tendering a cash payment; (ii) authorizing the Company to withhold shares of Common Stock from the
shares of Common Stock otherwise issuable to the Participant as a result of the exercise or acquisition of Common Stock under the Stock Award; provided, however, that no shares of Common Stock are withheld with a value exceeding the minimum amount
of tax required to be withheld by law (or such lower amount as may be necessary to avoid variable award accounting); or (iii) delivering to the Company owned and unencumbered shares of Common Stock. 
  
 (g) Information Obligation. To the extent required by Section
260.140.46 of Title 10 of the California Code of Regulations, the Company shall deliver financial statements to Participants at least annually. This Section 10(g) shall not apply to key Employees whose duties in connection with the Company assure
them access to equivalent information. 
  
 (h) Repurchase
Limitation. The terms of any repurchase option shall be specified in the Stock Award and may be either at Fair Market Value at the time of repurchase or at not less than the original purchase price. To the extent required by Section 260.140.41
and Section 260.140.42 of Title 10 of the California Code of Regulations at the time a Stock Award is made, any repurchase option contained in a Stock Award granted to a person who is not an Officer, Director or Consultant shall be upon the terms
described below: 
  
 (i) Fair Market
Value. If the repurchase option gives the Company the right to repurchase the shares of Common Stock upon termination of employment at not less than the Fair Market Value of the shares of Common Stock to be purchased on the date of termination
of Continuous Service, then (i) the right to repurchase shall be exercised for cash or cancellation of purchase money indebtedness for the shares of Common Stock within ninety (90) days of termination of Continuous Service (or in the case of shares
of Common Stock issued upon exercise of Stock Awards after such date of termination, within ninety (90) days after the date of the exercise) or such longer period as may be agreed to by the Company and the Participant (for example, for purposes of
satisfying the requirements of Section 1202(c)(3) of the Code regarding “qualified small business stock”) and (ii) the right terminates when the shares of Common Stock become publicly traded. 
  
 (ii) Original Purchase Price. If the repurchase
option gives the Company the right to repurchase the shares of Common Stock upon termination of Continuous Service at the 

  

 14 

 
original purchase price, then (i) the right to repurchase at the original purchase price shall lapse at the rate of at least twenty percent (20%) of the
shares of Common Stock per year over five (5) years from the date the Stock Award is granted (without respect to the date the Stock Award was exercised or became exercisable) and (ii) the right to repurchase shall be exercised for cash or
cancellation of purchase money indebtedness for the shares of Common Stock within ninety (90) days of termination of Continuous Service (or in the case of shares of Common Stock issued upon exercise of Options after such date of termination, within
ninety (90) days after the date of the exercise) or such longer period as may be agreed to by the Company and the Participant (for example, for purposes of satisfying the requirements of Section 1202(c)(3) of the Code regarding “qualified small
business stock”). 
  

	11.	ADJUSTMENTS UPON CHANGES IN STOCK. 

  
 (a) Capitalization Adjustments. If any change is made in, or other event occurs with respect to, the Common Stock subject to the Plan or subject to
any Stock Award without the receipt of consideration by the Company (through merger, consolidation, reorganization, recapitalization, reincorporation, stock dividend, dividend in property other than cash, stock split, liquidating dividend,
combination of shares, exchange of shares, change in corporate structure or other transaction not involving the receipt of consideration by the Company (each a “Capitalization Adjustment”), the Plan will be appropriately adjusted in the
class(es) and maximum number of securities subject to the Plan pursuant to Sections 4(a) and 4(b) and the maximum number of securities subject to award to any person pursuant to Section 5(c), and the outstanding Stock Awards will be appropriately
adjusted in the class(es) and number of securities and price per share of Common Stock subject to such outstanding Stock Awards. The Board shall make such adjustments, and its determination shall be final, binding and conclusive. (The conversion of
any convertible securities of the Company shall not be treated as a transaction “without receipt of consideration” by the Company.) 
  
 (b) Dissolution or Liquidation. In the event of a dissolution or liquidation of the Company, then all outstanding Stock Awards shall terminate
immediately prior to the completion of such dissolution or liquidation. 
  
 (c) Corporate Transaction. In the event of a Corporate Transaction, any surviving corporation or acquiring corporation may assume any or all Stock Awards outstanding under the Plan or may substitute similar stock awards for Stock
Awards outstanding under the Plan (it being understood that similar stock awards include, but are not limited to, awards to acquire the same consideration paid to the stockholders or the Company, as the case may be, pursuant to the Corporate
Transaction). In the event that any surviving corporation or acquiring corporation does not assume any or all such outstanding Stock Awards or substitute similar stock awards for such outstanding Stock Awards, then with respect to Stock Awards that
have been neither assumed nor substituted and that are held by Participants whose Continuous Service has not terminated prior to the effective time of the Corporate Transaction, the vesting of such Stock Awards (and, if applicable, the time at which
such Stock Awards may be exercised) shall (contingent upon the effectiveness of the Corporate Transaction) be accelerated in full to a date prior to the effective time of such Corporate Transaction as the Board shall determine (or, if the Board
shall not determine such a date, to the date that is five (5) days prior to the effective time of the Corporate Transaction), and the Stock Awards shall terminate if not exercised (if applicable) at or prior to 

  

 15 

 
such effective time. With respect to any other Stock Awards outstanding under the Plan that have been neither assumed nor substituted, the vesting of such
Stock Awards (and, if applicable, the time at which such Stock Award may be exercised) shall not be accelerated unless otherwise provided in a written agreement between the Company or any Affiliate and the holder of such Stock Award, and such Stock
Awards shall terminate if not exercised (if applicable) prior to the effective time of the Corporate Transaction. 
  
 (d) Change in Control. A Stock Award held by any Participant whose Continuous Service has not terminated prior to the effective time of a Change in
Control may be subject to additional acceleration of vesting and exercisability upon or after such event as may be provided in the Stock Award Agreement for such Stock Award or as may be provided in any other written agreement between the Company or
any Affiliate and the Participant, but in the absence of such provision, no such acceleration shall occur. 
  

	12.	AMENDMENT OF THE PLAN AND STOCK AWARDS. 

  
 (a) Amendment of Plan. The Board at any time, and from time to time, may amend the Plan. However, except as provided in Section II (a) relating to
Capitalization Adjustments, no amendment shall be effective unless approved by the stockholders of the Company to the extent stockholder approval is necessary to satisfy the requirements of Section 422 of the Code. 
  
 (b) Stockholder Approval. The Board, in its sole discretion, may
submit any other amendment to the Plan for stockholder approval. 
  
 (c) Contemplated Amendments. It is expressly contemplated that the Board may amend the Plan in any respect the Board deems necessary or advisable to provide eligible Employees with the maximum benefits provided or to be provided
under the provisions of the Code and the regulations promulgated thereunder relating to Incentive Stock Options and/or to bring the Plan and/or Incentive Stock Options granted under it into compliance therewith. 
  
 (d) No Impairment of Rights. Rights under any Stock Award granted
before amendment of the Plan shall not be impaired by any amendment of the Plan unless (i) the Company requests the consent of the Participant and (ii) the Participant consents in writing. 
  
 (e) Amendment of Stock Awards. The Board at any time, and from time to
time, may amend the terms of any one or more Stock Awards; provided, however, that the rights under any Stock Award shall not be impaired by any such amendment unless (i) the Company requests the consent of the Participant and (ii) the Participant
consents in writing. 
  

	13.	TERMINATION OR SUSPENSION OF THE PLAN. 

  
 (a) Plan Term. The Board may suspend or terminate the Plan at any time. Unless sooner terminated, the Plan shall terminate on the day before the
tenth (10th) anniversary of the date the Plan is adopted by the Board or approved by the stockholders of the Company, whichever is earlier. No Stock Awards may be granted under the Plan while the Plan is suspended or after it is terminated.

  

 16 

 (b) No Impairment of Rights. Suspension or termination of the Plan shall not impair rights and
obligations under any Stock Award granted while the Plan is in effect except with the written consent of the Participant. 
  

	14.	EFFECTIVE DATE OF PLAN. 

  
 The Plan shall become effective as determined by the Board, but no Stock Award shall be exercised (or, in the case of a stock bonus, shall be granted)
unless and until the Plan has been approved by the stockholders of the Company, which approval shall be within twelve (12) months before or after the date the Plan is adopted by the Board. 
  

	15.	CHOICE OF LAW. 

  
 The law of the State of California shall govern all questions concerning the construction, validity and interpretation of this Plan, without regard to
such state’s conflict of laws rules. 
  

 17

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