Document:

Property Management

Beal and Company, Inc., 177 Milk Street, Boston, Massachusetts
02109-3410

617 451-2100 Fax 617 451-1801

 

July 17, 2012

 

Arthur H. Tinkelenberg, PhD

President and CEO

Enumeral Biomedical Corp.

1450 Broadway, 245h Floor

New York, New York 10018

 

	Re:		EnumeralBiomedical
                                         Corp. – One Kendall Square

 

Dear Arthur:

 

Enclosed for your files please find one (1)
fully-executed counterpart of the Lease by and between Enumeral Biomedical Corp., as Tenant, and RB Kendall Fee, LLC, as Landlord,
dated July 16, 2012, with respect to Enumeral’s space at One Kendall Square, Cambridge, Massachusetts.

 

As you know, the Lease required delivery of
the Letter of Credit with execution. Debbie Howitt Easton provided you with a form of the LC that is satisfactory to Landlord.
Therefore, I am sending the enclosed Lease to you on the condition that by Wednesday, July 25th we will receive the
original Letter of Credit in a form that has been approved by Landlord.

 

Also before Tenant occupies the premises, please
provide the certificate of insurance to Erin Orpik, the Senior Property Manager at the Property.

 

Please contact me with
any questions or comments.

 

	 	Sincerely,
	 	 
	 	/s/ Deliris Colon 
	 	Deliris Colon 
	 	Lease Administrator

 

:dc

Enclosure

		cc:	Jonathan M. Lourie, Esquire (w/enc.)

			Erin S. Orpik, Senior Property Manager (w/o enc.)

			Deborah Howitt Easton, Esquire (w/o enc.)

 

    	 

    	 

    

 

EXHIBIT 1, SHEET 1

Building No. 400, One Kendall Square

Cambridge, Massachusetts

(the “Building”)

 

	Execution Date:	July 16, 2012
	 	 
	Tenant:	Enumeral Biomedical Corp.
	 	A Delaware corporation
	 	 
	Mailing Address:	One Kendall Square, Cambridge, Massachusetts 02139
	 	 
	Landlord:	RB Kendall Fee, LLC
	 	 
	Mailing address:	c/o The Beal Companies LLP, 177 Milk Street, Boston, Massachusetts 02109
	 	Attn: Senior Vice President – Asset Management
	 	 
	Building:	Building No.400 in One Kendall Square in the City of Cambridge, Middlesex
	 	County, Commonwealth of Massachusetts

  

		Art. 2	Premises: An area on the fourth (4th) floor of the Building, substantially
as shown on Lease Plan, Exhibit 2.

 

		Art. 3.1	Term Commencement Date: October 1, 2012

 

		Art. 3.2	Termination Date: November 30, 2015

 

		Art. 5	Use of Premises: Laboratory, research and development and general office use and
for no other purposes except in accordance with the terms of the Lease.

 

Yearly Rent/Monthly Rent:

 

	Time Period	 	Yearly Rent	 	 	Monthly Rent	 	 	P.S.F.	 
	October 1, 2012 - September 30, 2013	 	$	224,754.00	*	 	$	18,729,50	*	 	$	47.00	 
	October 1, 2013 – September 30, 2014	 	$	229,536.00	 	 	$	19,128.00	 	 	$	48.00	 
	October 1, 2014 – September 30, 2015	 	$	248,664.00	 	 	$	20,722.00	 	 	$	52.00	 
	October 1, 2015 – November 30, 2015	 	$	253,446.00	 	 	$	21,120.50	 	 	$	53.00	 

 

* Notwithstanding the foregoing, so long as
Tenant is not in default of this Lease beyond any applicable notice and cure period(s), Tenant shall be entitled to an abatement
of the Monthly Installments of the Yearly Rent (but not Tenant’s Operating Expense Excess or Tax Excess or other amounts
due hereunder, to the extent same are payable pursuant hereto), or so-called “free rent” period, for the month of October,
2012

 

		Art. 7	Total Rentable Area: 4,782 square feet

Total Rentable Area of Building No.400: 20,319 square feet

Total Rentable Area of Complex: 639,586 square feet

 

		Art. 8	Electric current will be furnished by Landlord to Tenant

 

    	 

    	 

    

 

		Art. 9	Operating and Taxes:

 

Tenant’s Proportionate Common Share: 0.75%

Tenant’s Proportionate Building Share: 23.53%

 

Art. 29.3 Broker: NAI Hunneman, for Tenant, and Cassidy Turley
FHO, for Landlord

 

Art. 29.5 Arbitration: Massachusetts; Superior Court

 

Art. 29.13 Security Deposit: $26,129.65
in the form of a Letter of Credit in accordance with Article 29.13

 

Art. 29.14 Parking Spaces: Four (4)
spaces

 

Art. 29.15 Option to Extend Term: One (1)
three (3) year term as set forth in Article 29.15

 

    	 

    	 

    

 

	1.	REFERENCE DATA	1
	 	 	 	 
	2.	DESCRIPTION OF DEMISED PREMISES	1
	 	2.1	Demised Premises 	1
	 	2.2	Appurtenant Rights 	1
	 	2.3	Exclusions and Reservations 	2
	 	 	 	 
	3.	TERM OF LEASE 	2
	 	3.1	Definitions	2
	 	3.2	Habendum	2
	 	3.3	Declaration Fixing Term Commencement Date	2
	 	 	 	 
	4.	READINESS FOR OCCUPANCY-ENTRY BY TENANT PRIOR TO TERM COMMENCEMENT DATE	3
	 	4.1	Acceptance of Premises 	3
	 	4.2	Tenant’s Work 	3
	 	 	 	 
	5.	USE OF PREMISES	3
	 	5.1	Permitted Use	3
	 	5.2	Prohibited Uses	3
	 	5.3	Licenses and Permits	3
	 	 	 	 
	6.	RENT	4
	 	 	 	 
	7.	RENTABLE AREA	4
	 	 	 	 
	8.	SERVICES FURNISHED BY LANDLORD 	4
	 	8.1	Electric Current 	4
	 	8.2	Water	6
	 	8.3	Elevators, Heat and Cleaning	6
	 	8.4	Air Conditioning	6
	 	8.5	Additional Heat and Air Conditioning Services	7
	 	8.6	Additional Air Conditioning Equipment	7
	 	8.7	Repairs	7
	 	8.8	Interruption or Curtailment of Services 	7
	 	8.9	Energy Conservation	8
	 	8.10	Access	8
	 	 	 	 
	9.	ESCALATION 	8
	 	9.1	Definitions	8
	 	9.2	Tax Share	12
	 	9.3	Operating Expense Share	12
	 	9.4	Part Years	13
	 	9.5	Effect of Taking	13
	 	9.6	Survival	13
	 	9.7	Tenant Audit Right	13
	 	 	 	 
	10.	CHANGES OR ALTERATIONS BY LANDLORD 	14
	 	 	 
	11.	FIXTURES, EQUIPMENT AND IMPROVEMENTS-REMOVAL BY TENANT	14
	 	 	 
	12.	ALTERATIONS AND IMPROVEMENTS BY TENANT 	15

 

 

    	 

    	 

    

 

	13.	TENANT’S CONTRACTORS-MECHANICS’ AND OTHER LIENS-STANDARD OF TENANT’S PERFORMANCE-COMPLIANCE WITH LAWS	15
	 	 	 
	14.	REPAIRS BY TENANT-FLOOR LOAD	16
	 	14.1	Repairs by Tenant	16
	 	14.2	Floor Load-Heavy Machinery	17
	 	 	 
	15.	INSURANCE, INDEMNIFICATION, EXONERATION AND EXCULPATION 	17
	 	15.1	General Liability Insurance	17
	 	15.2	Certificates of Insurance	18
	 	15.3	General	18
	 	15.4	Property of Tenant	18
	 	15.5	Bursting of Pipes, etc.	19
	 	15.6	Repairs and Alterations-No Diminution of Rental Value	19
	 	15.7	Landlord Insurance	19
	 	 	 
	16.	ASSIGNMENT, MORTGAGING AND SUBLETTING	19
	 	16.1	Generally	19
	 	16.2	Reimbursement, Recapture and Excess Rent 	21
	 	16.3	Certain Transfers/Miscellaneous	22
	 	 	 
	17.	MISCELLANEOUS COVENANTS 	23
	 	17.1	Rules and Regulations	23
	 	17.2	Access to Premises-Shoring	23
	 	17.3	Accidents to Sanitary and Other Systems	24
	 	17.4	Signs, Blinds and Drapes	24
	 	17.5	Estoppel Certificate and Financial Statements.	25
	 	17.6	Prohibited Materials and Property	25
	 	17.7	Requirements of Law-Fines and Penalties	25
	 	17.8	Tenant’s Acts—Effect on Insurance	26
	 	17.9	Miscellaneous	26
	 	 	 
	18.	DAMAGE BY FIRE, ETC.	26
	 	 	 
	19.	WAIVER OF SUBROGATION	27
	 	 	 
	20.	CONDEMNATION-EMINENT DOMAIN	27
	 	 	 
	21.	DEFAULT	29
	 	21.1	Conditions of Limitation-Re-Entry-Termination	29
	 	21.2	Intentionally Omitted	29
	 	21.3	Damages-Termination	29
	 	21.4	Fees and Expenses	30
	 	21.5	Waiver of Redemption	30
	 	21.6	Landlord’s Remedies Not Exclusive	30
	 	21.7	Grace Period	31
	 	 	 
	22.	END OF TERM-ABANDONED PROPERTY	31
	 	 	 
	23.	SUBORDINATION	32
	 	 	 
	24.	QUIET ENJOYMENT	33
	 	 	 
	25.	ENTIRE AGREEMENT-WAIVER-SURRENDER	34

    	 

    	 

    

 

	 	25.1	Entire Agreement	34
	 	25.2	Waiver by Landlord	34
	 	25.3	Surrender	34
	 	 	 
	26.	INABILITY TO PERFORM-EXCULPATORY CLAUSE 	34
	 	 	 
	27.	BILLS AND NOTICES 	35
	 	 	 
	28.	PARTIES BOUND-SEIZING OF TITLE 	36
	 	 	 
	29.	MISCELLANEOUS 	36
	 	29.1	Separability	36
	 	29.2	Captions, etc.	36
	 	29.3	Broker	36
	 	29.4	Modifications 	36
	 	29.5	Arbitration	37
	 	29.6	Governing Law	37
	 	29.7	Assignment of Rents	37
	 	29.8	Representation of Authority	37
	 	29.9	Expenses Incurred by Landlord Upon Tenant Requests	37
	 	29.10	Survival	38
	 	29.11	Hazardous Materials	38
	 	29.12	Patriot Act	39
	 	29.13	Letter of Credit	40
	 	29.14	Parking	41
	 	29.15	Tenant’s Option to Extend the Term of the Lease	42
	 	29.16	Definition of Fair Market Rental Value	42

 

Exhibit 2 - Lease Plan

Exhibit 2A - Tenant’s Work Letter

Exhibit 3 - Plan of Complex

Exhibit 4 - Term Commencement Date Agreement

Exhibit 5 - Form of Letter of Credit

 

    	 

    	 

    

 

THIS INDENTURE OF LEASE made and entered into
on the Execution Date as stated in Exhibit 1 and between the Landlord and the Tenant named in Exhibit 1.

 

Landlord and Tenant acknowledge and agree that
as of the Execution Date Tenant leases approximately 1,746 square feet of space in Building 1400 in the Complex(the “Existing
Premises”) pursuant to that certain Indenture of Lease dated April 28, 2011 (the “Prior Lease”). Landlord and
Tenant agree that after the Term Commencement Date of this Lease, and no later than November 30, 2012, Tenant shall surrender the
Existing Premises in accordance with the terms of the Prior Lease (including, without limitation, Section 29.11(f) ) and the Prior
Lease shall be deemed terminated and of no further force and effect. In addition to Tenant’s obligations under this Lease
(including the Monthly Rent obligations commencing November 1, 2012), Tenant shall remain liable to Landlord pursuant to the Prior
Lease for any and all amounts due and payable or accrued on or before the date of surrender (including, without limitation, Monthly
Rent provided therein) and for any amounts incurred by Landlord or due and payable under the Prior Lease in the event Tenant fails
to quit and deliver up the Existing Premises as required herein. If requested by Landlord, Tenant shall execute such other documentation
as Landlord may require to evidence the termination of the Prior Lease.

 

Landlord does hereby demise and lease to Tenant,
and Tenant does hereby hire and take from Landlord, the premises hereinafter mentioned and described (hereinafter referred to as
“Premises”), upon and subject to the covenants, agreements, terms, provisions and conditions of this Lease for the
term hereinafter stated:

 

1.          REFERENCE
DATA

 

Each reference in this Lease to any of the terms
and titles contained in any Exhibit attached to this Lease shall be deemed and construed to incorporate the data stated under that
term or title in such Exhibit.

 

2.          DESCRIPTION
OF DEMISED PREMISES

 

2.1           Demised
Premises. The Premises are that portion of the Building as described in Exhibit 1 (as the same may from time to time be constituted
after changes therein, additions thereto and eliminations therefrom pursuant to rights of Landlord hereinafter reserved) and is
hereinafter referred to as the “Building”, substantially as shown hatched or outlined on the Lease Plan (Exhibit 2)
hereto attached and incorporated by reference as a part hereof. Landlord reserves the right, at its own cost and expense, to require
Tenant, upon not less than sixty (60) days’ notice, to relocate its Premises elsewhere in the Building or Complex of which
the Building is a part, to an area of substantially equivalent size, layout, construction, utility and finish as designated by
Landlord and to include fixtures, appurtenances and leasehold improvements at least comparable in kind and quality to those contained
in the Premises at the time Landlord gives its Relocation Notice. Any dispute between the parties as to whether the area designated
by Landlord is “substantially equivalent” shall be submitted to arbitration pursuant to Article 29.5 hereof.

 

2.2           Appurtenant Rights.
Tenant shall have, as appurtenant to the Premises, rights to use in common with others entitled thereto, subject to reasonable
rules and regulations from time to time made by Landlord of which Tenant is given notice; (a) the common lobbies, hallways, stairways
and elevators of the Building, serving the Premises in common with others, (b) common walkways necessary for access to the Building,
and (c) if the Premises include less than the entire rentable area of any floor, the common toilets and other common facilities
of such floor; and no other appurtenant rights or easements. Notwithstanding anything to the contrary herein or in the Lease contained,
Landlord has no obligation to allow any particular telecommunication service provider to have access to the Building or to Tenant’s
Premises. If Landlord permits such access, Landlord may condition such access upon the payment to Landlord by the service provider
of fees assessed by Landlord in its sole discretion. During the term of the Lease, Tenant shall also have the right to use the
50kw emergency generator located on the roof of the Building that exclusively serves the Premises (the “Generator”).
Tenant agrees to perform, at Tenant’s sole cost, all necessary maintenance, repair and replacements to the Generator to keep
such Generator in good working order and repair at all times. Tenant shall keep in place at all times a service contract providing
for routine maintenance of the Generator, Landlord may require Tenant to use a roofing contractor selected by Landlord to perform
any work on the Generator that could damage, penetrate or alter the roof and Landlord may require anyone going on the roof to execute
in advance a liability waiver satisfactory to Landlord.

 

    	-1-

    	 

    

 

2.3           Exclusions
and Reservations. All the perimeter walls of the Premises except the inner surfaces thereof, any balconies (except to the extent
same are shown as part of the Premises on the Lease Plan (Exhibit 2)), terraces or roofs adjacent to the Premises, and any space
in or adjacent to the Premises used for shafts, stacks, pipes, conduits, wires and appurtenant fixtures, fan rooms, ducts, electric
or other utilities, sinks or other Building facilities, and the use thereof, as well as the right of access through the Premises
for the purposes of operation, maintenance, decoration and repair, are expressly excluded from the Premises and reserved to Landlord.

 

3.          TERM
OF LEASE

 

3.1           Definitions.
As used in this Lease the words and terms which follow mean and include the following:

 

(a)          Intentionally
omitted

 

(b)          “Term
Commencement Date” - October 1, 2012

 

(c)          “Complex”
shall be defined as all of the Building, the other buildings, and the Common Areas serving such buildings, all located on the land
(“Land”) shown outlined on Exhibit 3.

 

(d)          “Common
Areas” shall be defined as the common walkways, accessways, and parking facilities located on the Land and common facilities
in the Complex, as the same may be changed, from time to time, including without limitation, alleys, sidewalks, lobbies, hallways,
toilets, stairways, fan rooms, utility closets, shaftways, street entrances, elevators, wires, conduits, meters, pipes, ducts,
vaults, and any other equipment, machinery, apparatus, and fixtures wherever located on the Land, in the Complex, in the buildings
in the Complex or in the Premises that either (a) serve the Premises as well as other parts of the Land or Complex, or (b) serve
other parts of the Land or Complex but not the Premises.

 

3.2           Habendum.
TO HAVE AND TO HOLD the Premises for a term of years commencing on October 1, 2012 and ending at 11:59 p.m. on November 30, 2015
or on such earlier date upon which said term may expire or be terminated pursuant to any of the conditions of limitation or other
provisions of this Lease or pursuant to law (which date for the termination of the terms hereof will hereafter be called “Termination
Date”). Notwithstanding the foregoing, if the Termination Date as stated in Exhibit 1 shall fall on other than the last day
of a calendar month, said Termination Date shall, at the option of Landlord, be deemed to be the last day of the calendar month
in which said Termination Date occurs.

 

3.3           Declaration
Fixing Term Commencement Date. Landlord and Tenant hereby agree to execute a Term Commencement Date Agreement substantially
in the form attached hereto as Exhibit 4, or as otherwise reasonably requested by Landlord confirming the actual Term Commencement
Date and Termination Date, once same are determined. As soon as may be after the execution date hereof, each of the parties hereto
agrees, upon demand of the other party to join in the execution, in recordable form, of a statutory notice, memorandum, etc. of
lease. If this Lease is terminated before the term expires, then upon Landlord’s request the parties shall execute, deliver
and record an instrument acknowledging such fact and the date of termination of this Lease, and Tenant hereby appoints Landlord
its attorney-in-fact in its name and behalf to execute such instrument if Tenant shall fail to execute and deliver such instrument
after Landlord’s request therefor within ten (10) days. In no event shall this Lease be recorded or filed by Tenant with
the Middlesex South Registry of Deeds or Middlesex South Registry District of the Land Court.

 

    	-2-

    	 

    

 

4.          READINESS
FOR OCCUPANCY-ENTRY BY TENANT PRIOR TO TERM COMMENCEMENT DATE

 

4.1           Acceptance
of Premises. Tenant accepts the Premises "as is”, in the condition in which the Premises are in as of the Execution
Date, without any obligation on the part of Landlord to complete any work in the Premises or to prepare or construct the Premises
for Tenant’s occupancy and without any warranty or representation by Landlord as to the condition of the Premises, Building
or Complex.

 

4.2           Tenant’s
Work. Tenant shall perform, at its expense, and subject to the terms and conditions of this Lease, the work and installations
necessary or desirable for Tenant to operate at the Premises (“Tenant’s Work”), Tenant shall complete the Tenant’s
Work pursuant to the Work Letter attached hereto as Exhibit 2A. Tenant shall be liable for any damages or delays caused by Tenant’s
activities at the Premises in connection with Tenant’s Work.

 

5.          USE
OF PREMISES

 

5.1           Permitted
Use. Tenant shall during the term hereof occupy and use the Premises only for the purposes as stated in Exhibit 1 and for no
other purposes. Service and utility areas (whether or not a part of the Premises) shall be used only for the particular purpose
for which they were designed. Without limiting the generality of the foregoing, Tenant agrees that it shall not use the Premises
or any part thereof, or permit the Premises or any part thereof to be used for the preparation or dispensing of food, whether by
vending machines or otherwise. Notwithstanding the foregoing, but subject to the other terms and provisions of this Lease, Tenant
may, with Landlord’s prior written consent, which consent shall not be unreasonably withheld, install at its own cost and
expense so-called hot-cold water fountains, coffee makers and so-called Dwyer refrigerator-sink-stove combinations for the preparation
of beverages and foods, provided that no cooking, frying, etc., are carried on in the Premises to such extent as requires special
exhaust venting, Tenant hereby acknowledging that the Building is not engineered to provide any such special venting.

 

5.2           Prohibited
Uses. Notwithstanding any other provision of this Lease, Tenant shall not use, or suffer or permit the use or occupancy of,
or suffer or permit anything to be done in or anything to be brought into or kept in or about the Premises or the Building or any
part thereof (including, without limitation, any materials, appliances or equipment used in the construction or other preparation
of the Premises and furniture and carpeting): (i) which would violate any of the covenants, agreements, terms, provisions and conditions
of this Lease or that are otherwise applicable to or binding upon the Premises; (ii) for any unlawful purposes or in any unlawful
manner; (iii) which, in the reasonable judgment of Landlord shall in any way (a) impair the appearance or reputation of the Building;
or (b) impair, interfere with or otherwise diminish the quality of any of the Building services or the proper and economic heating,
cleaning, ventilating, air conditioning or other servicing of the Building or Premises, or with the use or occupancy of any of
the other areas of the Building, or occasion discomfort, inconvenience or annoyance, or injury or damage to any occupants of the
Premises or other tenants or occupants of the Building; or (iv) which is inconsistent with the maintenance of the Building as an
office, laboratory, R&D building of the first class in the quality of its maintenance, use, or occupancy. Tenant shall not
install or use any electrical or other equipment of any kind which, in the reasonable judgment of Landlord, might cause any such
impairment, interference, discomfort, inconvenience, annoyance or injury.

 

5.3           Licenses
and Permits. If any governmental license or permit shall be required for the proper and lawful conduct of Tenant’s business,
and if the failure to secure such license or permit would in any way affect Landlord, the Premises, the Building or Tenant’s
ability to perform any of its obligations under this Lease, Tenant, at Tenant’s expense, shall duly procure and thereafter
maintain such license and submit the same to inspection by Landlord. Tenant, at Tenant’s expense, shall at all times comply
with the terms and conditions of each such license or permit. Tenant shall furnish all data and information to governmental authorities
and Landlord as required in accordance with legal, regulatory, licensing or other similar requirements as they relate to Tenant’s
use or occupancy of the Premises or the Building.

 

    	-3-

    	 

    

 

6.           RENT

 

During the term of this Lease, the Yearly Rent
and other charges, at the rate stated in Exhibit 1, shall be payable by Tenant to Landlord by monthly payments, as stated in Exhibit
1, in advance and without demand on the first day of each month for and in respect of such month. The rent and other charges reserved
and covenanted to be paid under this Lease shall commence on the Term Commencement Date. Notwithstanding the provisions of the
next preceding sentence, Tenant shall pay the first monthly installment of rent on the execution of this Lease even if the rent
payments commence later than the Term Commencement Date or if there is a free rent period. If, by reason of any provisions of this
Lease, the rent reserved hereunder shall commence or terminate on any day other than the first day of a calendar month, the rent
for such calendar month shall be prorated. The rent and all other amounts payable to Landlord at the address provided in Exhibit
1 to this Lease or, if Landlord shall so direct in writing, to Landlord’s agent or nominee, in lawful money of the United
States which shall be legal tender for payment of all debts and dues, public and private, at the time of payment, at the office
of the Landlord or such place as Landlord may designate, and the rent and other charges in all circumstances shall be payable without
any setoff or deduction whatsoever, Rental and any other sums due hereunder not paid on or before the date due shall bear interest
for each month or fraction thereof from the due date until paid computed at the annual rate of five percentage (5%) points over
the so-called prime rate then currently from time to time charged to its most favored corporate customers by the largest national
bank (N.A.) located in the city in which the Building is located, or at any applicable lesser maximum legally permissible rate
for debts of this nature.

 

7.           RENTABLE
AREA

 

Total Rentable Area of the Premises, the Building
and the Complex are agreed to be the amounts set forth in Exhibit 1. Landlord reserves the right, throughout the term of the Lease,
to recalculate the Total Rentable Area of the Building and/or the Complex in the event of a physical change to the Building and/or
Complex, such as, by way of example and not limitation, increases or decreases in the Common Areas or rentable areas within same,
and not solely by reason of the re-measurement by Landlord of the same without a physical change.

 

8.           SERVICES
FURNISHED BY LANDLORD

 

8.1           Electric
Current.

 

(a)          As
stated in Exhibit 1, Tenant will reimburse Landlord for the cost of all electric current utilized in the Premises (including all
associated with the Generator) as measured by separate submeter(s) or checkmeter(s), as hereinafter set forth or Landlord shall
require Tenant to contract with the company supplying electric current for the purchase and obtaining by Tenant of electric current
directly from such company to be billed directly to, and paid for by, Tenant.

 

(b)          Tenant
shall reimburse Landlord for the entire cost of such electric current as follows:

 

(1)         Commencing
as of the Term Commencement Date and continuing until the procedures set forth in Paragraph 2 of this Article 8.1(b) are effected,
Tenant shall pay to Landlord at the same time and in the same manner that it pays its monthly payments of Yearly Rent hereunder,
estimated payments (i.e., based upon Landlord’s reasonable estimate) on account of Tenant’s obligation to reimburse
Landlord for electricity consumed in the Premises.

 

    	-4-

    	 

    

 

(2)         Periodically
after the Term Commencement Date, Landlord shall determine the actual cost of electricity consumed by Tenant in the Premises (i.e.
by reading Tenant’s submeter(s) and by applying an electric rate which shall not exceed the retail rate which would have
been payable by Tenant had Tenant obtained electric services directly from the utility company providing electric current to Landlord.)
If the total of Tenant’s estimated monthly payments on account of such period is less than the actual cost of electricity
consumed in the Premises during such period, Tenant shall pay the difference to Landlord within thirty (30) days of when billed
therefor. If the total of Tenant’s estimated monthly payments on account of such period is greater than the actual cost of
electricity consumed in the Premises during such period, Tenant may credit the difference against its next installment of rental
or other charges due hereunder, provided that any excess credit shall be repaid to Tenant within a reasonable time following the
expiration of the Lease term provided Tenant is not in default under this Lease.

 

(3)         After
each adjustment, as set forth in Paragraph 2 above, the amount of estimated monthly payments on account of Tenant’s obligation
to reimburse Landlord for electricity in the Premises shall be adjusted based upon the actual cost of electricity consumed during
the immediately preceding period.

 

(c)          Landlord,
at any time, at its option and upon not less than thirty (30) days’ prior written notice to Tenant, may discontinue such
furnishing of electric current to the Premises; and in such case Tenant shall contract with the company supplying electric current
for the purchase and obtaining by Tenant of electric current directly from such company. In the event Tenant itself contracts for
electricity with the supplier, pursuant to Landlord’s option as above stated, Landlord shall (i) permit its risers, conduits
and feeders to the extent available, suitable and safely capable, to be used for the purpose of enabling Tenant to purchase and
obtain electric current directly from such company, (ii) without cost or charge to Tenant, make such alterations and additions
to the electrical equipment and/or appliances in the Building as such company shall specify for the purpose of enabling Tenant
to purchase and obtain electric current directly from such company, and (iii) at Landlord’s expense, furnish and install
in or near the Premises any necessary metering equipment used in connection with measuring Tenant’s consumption of electric
current and Tenant, at Tenant’s expense, shall maintain and keep in repair such metering equipment.

 

(d)          Whether
or not Landlord is furnishing electric current to Tenant, if Tenant shall require electric current for use in the Premises in excess
of such reasonable quantity to be furnished for such use as hereinabove provided and if (i) in Landlord’s reasonable judgment,
Landlord’s facilities are inadequate for such excess requirements or (ii) such excess use shall result in an additional burden
on the Building air conditioning system and additional cost to Landlord on account thereof, then, as the case may be, (x) Landlord,
upon written request and at the sole cost and expense of Tenant, will furnish and install such additional wire, conduits, feeders,
switchboards and appurtenances as reasonably may be required to supply such additional requirements of Tenant if current therefor
be available to Landlord, provided that the same shall be permitted by applicable laws and insurance regulations and shall not
cause damage to the Building or the Premises or cause or create a dangerous or hazardous condition or entail excessive or unreasonable
alterations or repairs or interfere with or disturb other tenants or occupants of the Building or (y) Tenant shall reimburse Landlord
for such additional cost, as aforesaid. Tenant acknowledges that it has been provided with an opportunity to confirm that the electric
current serving the Premises will be adequate to supply its proposed permitted uses of the Premises.

 

(e)          Landlord,
at Tenant’s expense and upon Tenant’s request, shall purchase and install all replacement lamps of types generally
commercially available (including, but not limited to, incandescent and fluorescent) used in the Premises.

 

(f)          Landlord
shall not in any way be liable or responsible to Tenant for any loss, damage or expense which Tenant may sustain or incur if the
quantity, character, or supply of electrical energy is changed or is no longer available or suitable for Tenant’s requirements,
subject to Section 8.8 below.

 

(g)          Tenant
agrees that it will not make any material alteration or material addition to the electrical equipment and/or appliances in the
Premises without the prior written consent of Landlord in each instance first obtained, which consent will not be unreasonably
withheld, and using contractor(s) approved by Landlord, and will promptly advise Landlord of any other alteration or addition to
such electrical equipment and/or appliances.

 

    	-5-

    	 

    

 

8.2           Water.
Landlord shall furnish hot and cold water for ordinary Premises, cleaning, toilet, lavatory and drinking purposes. If Tenant requires,
uses or consumes water for any purpose other than for the aforementioned purposes, Landlord may (i) assess a reasonable charge
for the additional water so used or consumed by Tenant or (ii) install a water meter and thereby measure Tenant’s water consumption
for all purposes. In the latter event, Tenant shall pay the cost of the meter and the cost of installation thereof and shall keep
said meter and installation equipment in good working order and repair. Tenant agrees to pay for water consumed, as shown on said
meter, together with the sewer charge based on said meter charges, as and when bills are rendered, and on default in making such
payment Landlord may pay such charges and collect the same from Tenant. All piping and other equipment and facilities for use of
water outside the building core will be installed and maintained by Landlord at Tenant’s sole cost and expense.

 

8.3           Elevators,
Heat and Cleaning. Landlord shall: (i) provide necessary elevator facilities (which may be manually or automatically operated,
either or both, as Landlord may from time to time elect) on Mondays through Fridays, excepting Massachusetts and federal
legal holidays, from 8:00 a.m. to 6:00 p.m. and on Saturdays, excepting legal holidays, from 8:00 a.m. to 1:00 p.m. (called “business
days”) and have one (1) elevator in operation available for Tenant’s use, non-exclusively, together with others having
business in the Building, at all other times; (ii) furnish heat (substantially equivalent to that being furnished in comparably
aged similarly equipped office, laboratory, R&D buildings in the same city) to the Premises during the normal heating season
on business days; (iii) cause the common areas of the Building to be cleaned on Monday through Friday (excepting Massachusetts
or City of Cambridge legal holidays) in a manner consistent with cleaning standards generally prevailing in the comparable office,
laboratory, R&D buildings in the City of Cambridge, and (iv) provide commercially reasonable twenty-four (24) hour security
to the Building, after normal business hours in the form of roving security guards or such other security measures as Landlord
reasonably deems appropriate. All costs and expenses incurred by Landlord in connection with foregoing services shall be included
as part of the Operating Costs (as defined below). Tenant shall be responsible, at its sole cost and expense, for providing cleaning
and janitorial services to the Premises in a neat and first-class manner consistent with the cleaning standards generally prevailing
in the comparable buildings in the City of Cambridge or as otherwise reasonably established by Landlord in writing from time to
time using an insured contractor or contractors selected by Tenant and approved in writing by Landlord and such provider shall
not interfere with the use and operation of the Building or Complex by Landlord or any other tenant or occupant thereof. Landlord
shall deliver in good condition and repair the base Building systems serving the Premises (including, without limitation, sanitary,
electrical, heating, air conditioning, or other systems), subject to Section 8.7 below. Landlord shall also be responsible for
the on-going maintenance, repair and replacement of said systems subject to inclusion in Operating Costs as hereinafter described.
Tenant may elect to contract with Landlord’s cleaning service to clean the Premises in which case the cost of such service
will be billed either directly to Tenant or through Operating Costs. Landlord shall provide a dumpster and/or compactor at in such
location as Landlord may designate from time to time for Tenant’s use, in common with other tenants in the Complex, in discarding
non-hazardous substances.

 

8.4           Air
Conditioning. Landlord shall through the air conditioning equipment of the Building furnish to and distribute in the Premises
air conditioning as normal seasonal changes may require on business days during the hours as aforesaid in Article 8.3 when air
conditioning may reasonably be required for the comfortable occupancy of the Premises by Tenant. Tenant agrees to lower and close
the blinds or drapes when necessary because of the sun’s position, whenever the air conditioning system is in operation,
and to cooperate fully with Landlord with regard to, and to abide by all the reasonable regulations and requirements which Landlord
may prescribe for the proper functioning and protection of the air conditioning system.

 

    	-6-

    	 

    

 

8.5         Additional
Heat and Air Conditioning Services. Landlord will use reasonable efforts upon reasonable advance written notice from Tenant
of its requirements in that regard, to furnish additional heat or air conditioning services to the Premises on days and at times
other than as above provided. Tenant will pay to Landlord a reasonable charge for any such additional heat or air conditioning
service required by Tenant.

 

8.6         Additional
Air Conditioning Equipment. In the event Tenant requires additional air conditioning for business machines, meeting rooms or
other special purposes, or because of occupancy or excess electrical loads, any additional air conditioning units, chillers, condensers,
compressors, ducts, piping and other equipment, such additional air conditioning equipment will be installed, but only if, in Landlord’s
reasonable judgment, the same will not cause damage or injury to the Building or create a dangerous or hazardous condition or entail
excessive or unreasonable alterations, repairs or expense or interfere with or disturb other tenants. At Landlord’s sole
election, such equipment will either be installed:

 

(a)          by
Landlord at Tenant’s expense and Tenant shall reimburse Landlord in such an amount as will compensate it for the cost incurred
by it in operating, maintaining, repairing and replacing, if necessary, such additional air conditioning equipment. At Landlord’s
election, such equipment shall (i) be maintained, repaired and replaced by Tenant at Tenant’s sole cost and expense, and
(ii) throughout the term of this Lease, Tenant shall, at Tenant’s sole cost and expense, purchase and maintain a service
contract for such equipment from a service provider approved by Landlord. Tenant shall obtain Landlord’s prior written approval
of both the form of service contract and of the service provider; or

 

(b)          by
Tenant, subject to Landlord’s prior approval of Tenant’s plans and specifications for such work. In such event: (i)
such equipment shall be maintained, repaired and replaced by Tenant at Tenant’s sole cost and expense, and (ii) throughout
the term of this Lease, Tenant shall, at Tenant’s sole cost and expense, purchase and maintain a service contract for such
equipment from a service provider approved by Landlord. Tenant shall obtain Landlord’s prior written approval of both the
form of service contract and of the service provider.

 

8.7         Repairs.
Except as otherwise provided in Articles 18 and 20, and subject to Tenant’s obligations in Article 14, Landlord shall repair,
keep and maintain the roof, exterior walls, structural floor slabs, columns, elevators, public stairways and corridors, parking
areas, parking deck, loading docks, public lavatories, and other common equipment (including, without limitation, sanitary, electrical,
heating, air conditioning, or other systems) serving both the Building and the Common Areas in good condition and repair. Landlord
shall keep the paved portions of the Common Areas reasonably free of ice and snow. All of the foregoing shall be included in Operating
Costs as and to the extent provided in Article 9 below.

 

8.8         Interruption
or Curtailment of Services. When necessary by reason of accident or emergency, or for repairs, alterations, replacements or
improvements which in the reasonable judgment of Landlord are desirable or necessary to be made, or of difficulty or inability
in securing supplies or labor, or of strikes, or of any other cause beyond the reasonable control of Landlord, whether such other
cause be similar or dissimilar to those hereinabove specifically mentioned until said cause has been removed, Landlord reserves
the right to interrupt, curtail, stop or suspend (i) the furnishing of heating, elevator, air conditioning, and cleaning services
and (ii) the operation of the plumbing and electric systems. Landlord shall exercise reasonable diligence to eliminate the cause
of any such interruption, curtailment, stoppage or suspension, but there shall be no diminution or abatement of rent or other compensation
due from Landlord to Tenant hereunder, nor shall this Lease be affected or any of the Tenant’s obligations hereunder reduced,
and the Landlord shall have no responsibility or liability for any such interruption, curtailment, stoppage, or suspension of services
or systems. Notwithstanding the foregoing, Tenant shall be entitled to a proportionate abatement of Yearly Rent in the event of
a Landlord Service Interruption (as defined below). For the purposes hereof, a “Landlord Service Interruption” shall
occur in the event (i) the Premises shall lack any service which Landlord is required to provide hereunder thereby rendering the
Premises untenantable for the entirety of the Landlord Service Interruption Cure Period (as defined below), (ii) such lack of service
was not caused by Tenant, its employees contractors, invitees or agents; (iii) Tenant in fact ceases to use the entire Premises
for the entirety of the Landlord Service Interruption Cure Period; and (iii) such interruption of service was the result of causes,
events or circumstances within the Landlord’s reasonable control and the cure of such interruption is within Landlord’s
reasonable control. For the purposes hereof, the “Landlord Service Interruption Cure Period” shall be defined as fifteen
(15) consecutive business days after Landlord’s receipt of written notice from Tenant of the Landlord Service Interruption.

 

    	-7-

    	 

    

 

8.9           Energy
Conservation. Notwithstanding anything to the contrary in this Article 8 or in this Lease contained, Landlord may institute,
and Tenant shall comply with, such policies, programs and measures as may be necessary, required, or expedient for the conservation
and/or preservation of energy or energy services, or as may be necessary or required to comply with applicable codes, rules regulations
or standards.

 

8.10         Access.
Subject to terms and conditions of this Lease, matters of force majeure, closures due to casualty or condemnation or necessary
repairs, Landlord’s rules and regulations and reasonable security requirements as the same may be amended from time to time
and of which Tenant has received prior written notice, Tenant shall have access to the Premises and all Common Areas and parking
areas appurtenant to the Premises twenty-four (24) hours a day, seven (7) days a week. Landlord shall have the right to control
access to the Building via card key access systems and/or other security systems on the entry doors thereto from time to time.

 

9.           ESCALATION

 

9.1           Definitions.
As used in this Article 9, the words and terms which follow mean and include the following:

 

(a)          “Operating
Year” shall mean a calendar year in which occurs any part of the term of this Lease.

 

(b)          “Tenant’s
Proportionate Building Share” shall initially be the figure as stated in Exhibit 1. Tenant’s Proportionate Building
Share is the ratio of the Total Rentable Area of the Premises to the aggregate Total Rentable Area of the Building, from time to
time. As changes or modifications to the Building occurs, Tenant’s Proportionate Building Share shall be adjusted to equal
the then current ratio of the Total Rentable Area of the Premises to the aggregate Total Rentable Area within the Building which
is then completed and as to which a certificate of occupancy is issued.

 

(c)          “Tenant’s
Proportionate Common Share” shall initially be the figure as stated in Exhibit 1. Tenant’s Proportionate Common Share
is the ratio of the Total Rentable Area of the Premises to the aggregate Total Rentable Area, from time to time, of all buildings
within the Complex which have been completed and for which a certificate of occupancy has been issued. As additional buildings
are completed within the Complex, Tenant’s Proportionate Common Share shall be adjusted to equal the then current ratio of
the Total Rentable Area of the Premises to the aggregate Total Rentable Area within the Complex which is then completed and as
to which a certificate of occupancy is issued.

 

(d)          “Taxes”
shall mean the real estate taxes and other taxes, levies and assessments imposed upon the Building and the Common Areas of the
Complex and upon any personal property of Landlord used in the operation thereof, or Landlord’s interest in the Building,
the Common Areas, or such personal property; charges, fees and assessments for transit, housing, police, fire or other governmental
services or purported benefits to the Building and/or the Common Areas; service or user payments in lieu of taxes; and any and
all other taxes, levies, betterments, assessments and charges arising from the ownership, leasing, operating, use or occupancy
of the Building, the Common Areas or based upon rentals derived therefrom, which are or shall be imposed by Federal, State, Municipal
or other authorities. As of the Execution Date, “Taxes” shall not include any franchise, rental, income or profit tax,
capital levy or excise, provided, however, that any of the same and any other tax, excise, fee, levy, charge or assessment, however
described, that may in the future be levied or assessed as a substitute for or an addition to, in whole or in part, any tax, levy
or assessment which would otherwise constitute “Taxes,” whether or not now customary or in the contemplation of the
parties on the Execution Date of this Lease, shall constitute “Taxes,” but only to the extent calculated as if the
Complex is the only real estate owned by Landlord. “Taxes” shall also include expenses of tax abatement or other proceedings
contesting assessments or levies. The parties acknowledge that, as of the Execution Date, Taxes are based upon several separate
tax bills affecting the Complex. Taxes shall be allocated by Landlord, in Landlord’s reasonable judgment, among the Building
(the portion of Taxes allocable to the Building being referred to herein as “Building Taxes”), the other buildings
of the Complex, and the Common Areas (the portion of Taxes allocable to the Common Areas being referred to herein as “Common
Area Taxes”).

 

    	-8-

    	 

    

 

(e)          “Tax
Period” shall be any fiscal/tax period in respect of which Taxes are due and payable to the appropriate governmental taxing
authority, any portion of which period occurs during the term of this Lease, the first such Period being the one in which the Term
Commencement Date occurs.

 

(f)          “Operating
Costs”:

 

(1)         Definition
of Operating Costs. “Operating Costs” shall mean all costs incurred and expenditures of whatever nature made by
Landlord in the operation and management, for repair and replacements, cleaning and maintenance of the Building, the Complex, and
the Common Areas of the Complex including, without limitation, vehicular and pedestrian passageways related to the Complex, related
equipment, facilities and appurtenances, elevators, cooling and heating equipment. In the event that Landlord or Landlord’s
managers or agents perform services for the benefit of the Complex off-site which would otherwise be performed on-site (e.g., accounting),
the cost of such services shall be reasonably allocated among the properties benefiting from such service and shall be included
in Operating Costs. Landlord shall have the right but not the obligation, from time to time, to equitably allocate some or all
of the Operating Costs among different tenants of the Building or properties (the “Cost Pools”). Such Cost Pools may
include, but shall not be limited to, tenants that share particular systems or equipment or tenants that are similar users of particular
systems or equipment such as by way of example but not limitation the office space tenants of the Building or properties, the laboratory
or incubator tenants of the Building or properties and the retail space tenants of the Building or properties. Operating Costs
shall include, without limitation, those categories of “Specifically Included Operating Costs,” as set forth below,
but shall not include “Excluded Costs,” as hereinafter defined.

 

(2)         Definition
of Excluded Costs. “Excluded Costs” shall be defined as mortgage charges, brokerage commissions, salaries of executives
and owners not directly employed in the management/operation of the Complex, the cost of work done by Landlord for a particular
tenant for which Landlord has the right to be reimbursed by such tenant, and, subject to Subparagraph (3) below, such portion of
expenditures as are not properly chargeable against income. In addition, the following items shall also be “Excluded Costs”:
(a) amounts reimbursed or paid to Landlord directly by other tenants of the Building (including Tenant), from insurance proceeds
or pursuant to any warranty; (b) any debt service related to indebtedness secured in whole or in part by the Building or the Land;
(c) costs, fines or penalties incurred due to violations by Landlord or any management company employed by Landlord of any leases
or any governmental laws, rules or regulations; (d) franchise or income taxes imposed upon Landlord; (e) leasing commissions and
other costs of marketing space in the Building; (f) depreciation on the Building and equipment; (g) the cost of tenant installations
incurred in connection with preparing premises for a new tenant; (h) salaries of personnel above the grade of General Manager or
Senior Property Manager (and/or such other grade or title of any person performing property management functions); (i) legal fees
incurred in connection with any negotiation or enforcement of any space lease in the Building; (j) costs and expenses incurred
in connection with the creation of a mortgage or in connection with the refinancing of a mortgage or the sale of the Building or
the Land or any portion thereof; (k) the cost of electrical energy furnished and paid directly to Tenant or any other tenant of
the Building; (1) amounts paid on account of tort claims relating to personal injury or property damage (excluding commercially
reasonable deductibles); (m) the cost of any special work or service performed for or facilities furnished to a tenant which are
not generally offered or available to other tenants of the Building; (n) reserves; (o) any capital expenditures other than as expressly
provided herein; and (p) any rent loss or other bad debt.

 

    	-9-

    	 

    

 

(3)         Capital
Expenditures.

 

(i)          Replacements.
If, during the term of this Lease, Landlord shall replace any capital items or make any capital expenditures (collectively called
“capital expenditures”) the total amount of which is not properly includible in Operating Costs for the Operating Year
in which they were made, there shall nevertheless be included in such Operating Costs and in Operating Costs for each succeeding
Operating Year the amount, if any, by which the Annual Charge-Off (determined as hereinafter provided) of such capital expenditure
(less insurance proceeds, if any, collected by Landlord by reason of damage to, or destruction of the capital item being replaced)
exceeds the Annual Charge-Off of the capital expenditure for the item being replaced.

 

(ii)         New
Capital Items. If a new capital item is acquired which does not replace another capital item which was worn out, has become
obsolete, etc., then there shall be included in Operating Costs for each Operating Year in which and after such capital expenditure
is made the Annual Charge-Off of such capital expenditure.

 

(iii)        Annual
Charge-Off. “Annual Charge-Off” shall be defined as the annual amount of principal and interest payments which
would be required to repay a loan (“Capital Loan”) in equal monthly installments over the Useful Life, as hereinafter
defined, of the capital item in question on a direct reduction basis at an annual interest rate equal to the Capital Interest Rate,
as hereinafter defined, where the initial principal balance is the cost of the capital item in question. Notwithstanding the foregoing,
if Landlord reasonably concludes on the basis of engineering estimates that a particular capital expenditure will effect savings
in Building operating expenses including, without limitation, energy- related costs, and that such projected savings will, on an
annual basis (“Projected Annual Savings”), exceed the Annual Charge-Off of such capital expenditure computed as aforesaid,
then and in such events, the Annual Charge-Off shall be increased to an amount equal to the Projected Annual Savings; and in such
circumstances, the increased Annual Charge-Off (in the amount of the Projected Annual Savings) shall be made for such period of
time as it would take to fully amortize the cost of the capital item in question, together with interest thereon at the Capital
Interest Rate as aforesaid, in equal monthly payments, each in the amount of one-twelfth (1/12th) of the Projected Annual Savings,
with such payments being applied first to interest and the balance to principal.

 

(iv)        Useful
Life. “Useful Life” shall be reasonably determined by Landlord in accordance with generally accepted accounting
principles and practices in effect at the time of acquisition of the capital item.

 

    	-10-

    	 

    

 

(v)         Capital
Interest Rate. “Capital Interest Rate” shall be defined as an annual rate of either one percentage point over the
AA Bond rate (Standard & Poor’s corporate composite or, if unavailable, its equivalent) as reported in the financial
press at the time the capital expenditure is made or, if the capital item is acquired through third-party financing, then the actual
(including fluctuating) rate paid by Landlord in financing the acquisition of such capital item.

 

(4)         Specifically
included Categories of Operating Costs. Operating Costs shall include, but not be limited to, the following:

 

Taxes (other than
real estate taxes): Sales, Federal Social Security, Unemployment and Old Age Taxes and contributions and State Unemployment taxes
and contributions accruing to and paid by the Landlord on account of all employees of Landlord and/or Landlord’s managing
agent, who are employed in, about or on account of the Complex, except that taxes levied upon the net income of the Landlord and
taxes withheld from employees, and “Taxes” as defined in Article 9.1(d) shall not be included herein.

 

Water: All charges
and rates connected with water supplied to the Building and related sewer use charges.

 

Heat and Air Conditioning:
All charges connected with heat and air conditioning supplied to the Building.

 

Wages: Wages and
cost of all employee benefits of all employees of the Landlord and/or Landlord's managing agent who are employed in, about or on
account of the Building.

 

Cleaning: The cost
of labor (including third party janitorial contracts), supplies, tools and material for cleaning the Building and Complex.

 

Elevator Maintenance:
All expenses for or on account of the upkeep and maintenance of all elevators in the Building.

 

Management Fee:
The cost of professional management of the Complex, the fee for which shall not exceed five percent (5%) of the gross revenue of
the Complex.

 

Administrative
Costs: The commercially reasonable cost of office expense for the management of the Complex, including, without limitation, rent,
business supplies and equipment.

 

Electricity: The
cost of all electric current for the operation of any machine, appliance or device used for the operation of the Premises and the
Building, including the cost of electric current for the elevators, lights, air conditioning and heating, but not including electric
current which is paid for directly to the utility by the user/tenant in the Building or for which the user/tenant reimburses Landlord.
(If and so long as Tenant is billed directly by the electric utility for its own consumption as determined by its separate meter,
or billed directly by Landlord as determined by a check meter, then Operating Costs shall include only Building and public area
electric current consumption and not any demised Premises electric current consumption.) Wherever separate metering is unlawful,
prohibited by utility company regulation or tariff or is otherwise impracticable, relevant consumption figures for the purposes
of this Article 9 shall be determined by fair and reasonable allocations and engineering estimates made by Landlord.

 

    	-11-

    	 

    

 

Insurance, etc.:
Fire, casualty, liability, rent loss and such other insurance as may from time to time be required by lending institutions on first-class
office, laboratory, R&D buildings in the City or Town wherein the Building is located and all other expenses customarily incurred
in connection with the operation and maintenance of first-class office, laboratory, R&D buildings in the City or Town wherein
the Building is located including, without limitation, insurance deductible amounts.

 

(5)         Definitions
of Building Operating Costs and Common Area Operating Costs. “Building Operating Costs” shall be defined
as the amount of Operating Costs allocable to the Building in any Operating Year. “Common Area Operating Costs” shall
be defined as the amount of Operating Costs allocable to the Common Areas in any Operating Year. All Operating Costs incurred by
Landlord in respect of the Complex shall be allocated, in Landlord’s reasonable judgment, among the Building, the other buildings
of the Complex, and the Common Areas.

 

(6)         Gross-Up
Provision. Notwithstanding the foregoing, in determining the amount of Operating Costs for any calendar year or any portion
thereof falling within the term, if less than ninety-five percent (95%) of the Rentable Area of the Building shall have been occupied
by tenants at any time during the period in question, then, at Landlord’s election, Operating Costs for such period shall
be adjusted to equal the amount Operating Costs would have been for such period had occupancy been ninety-five percent (95%) throughout
such period. The extrapolation of Operating Costs under this paragraph shall be performed by appropriately adjusting the cost of
those components of Operating Costs that are impacted by changes in the occupancy of the Building.

 

9.2           Tax
Share. Commencing as of the Term Commencement Date and continuing thereafter with respect to each Tax Year occurring during
the term of the Lease, Tenant shall pay to Landlord, with respect to any Tax Period, the sum of: (x) Tenant’s Proportionate
Building Share of Building Taxes for such Tax Period, plus (y) Tenant’s Proportionate Common Share of Common Area Taxes for
such Tax Period, such sum being hereinafter referred to as “Tax Share”. Tax Share shall be due when billed by Landlord.
In implementation and not in limitation of the foregoing, Tenant shall remit to Landlord pro rata monthly installments on account
of projected Tax Share, calculated by Landlord on the basis of the most recent Tax data or budget available. If the total of such
monthly remittances on account of any Tax Period is greater than the actual Tax Share for such Tax Period, Landlord may credit
the difference against the next installment of rental or other charges due to Landlord hereunder. If the total of such remittances
is less than the actual Tax Share for such Tax Period, Tenant shall pay the difference to Landlord within thirty (30) days of when
billed therefor.

 

Appropriate credit against Tax Share shall be
given for any refund obtained by reason of a reduction in any Taxes by the Assessors or the administrative, judicial or other governmental
agency responsible therefor, The original computations, as well as reimbursement or payments of additional charges, if any, or
allowances, if any, under the provisions of this Article 9.2 shall be based on the original assessed valuations with adjustments
to be made at a later date when the tax refund, if any, shall be paid to Landlord by the taxing authorities. Expenditures for reasonable
legal fees and for other similar or dissimilar expenses incurred in obtaining the tax refund may be charged against the tax refund
before the adjustments are made for the Tax Period.

 

9.3           Operating
Expense Share. Commencing as of the Term Commencement Date and continuing thereafter with respect to each Operating Year occurring
during the term of the Lease, Tenant shall pay to Landlord, with respect to any Operating Year, the sum of: (x) Tenant’s
Proportionate Building Share of Building Operating Costs for such Operating Year, plus (y) Tenant’s Proportionate Common
Share of Common Operating Costs for such Operating Year, such sum being hereinafter referred to as “Operating Expense Share”.
In implementation and not in limitation of the foregoing, Tenant shall remit to Landlord pro rata monthly installments on account
of projected Operating Expense Share, calculated by Landlord on the basis of the most recent Operating Costs data or budget available.
If the total of such monthly remittances on account of any Operating Year is greater than the actual Operating Expense Share for
such Operating Year, Landlord may credit the difference against the next installment of rent or other charges due to Landlord hereunder.
If the total of such remittances is less than actual Operating Expense Share for such Operating Year, Tenant shall pay the difference
to Landlord within thirty (30) days of when billed therefor.

 

    	-12-

    	 

    

 

9.4           Part
Years. If the Term Commencement Date or the Termination Date occurs in the middle of an Operating Year or Tax Period, Tenant
shall be liable for only that portion of the Operating Expense or Tax Share as the case may be, in respect of such Operating Year
or Tax Period represented by a fraction, the numerator of which is the number of days of the herein term which falls within the
Operating Year or Tax Period and the denominator of which is three hundred sixty-five (365), or the number of days in said Tax
Period, as the case may be.

 

9.5           Effect
of Taking. In the event of any taking of the Building or the land upon which it stands under circumstances whereby this
Lease shall not terminate under the provisions of Article 20 then, Tenant’s Proportionate Building Share and
Tenant’s Proportionate Common Share shall be adjusted appropriately to reflect  the proportion of the Premises and/or
the Building remaining after such taking.

 

9.6           Survival.
Any obligations under this Article 9 which shall not have been paid at the expiration or sooner termination of the term of this
Lease shall survive such expiration and shall be paid when and as the amount of same shall be determined to be due.

 

9.7           Tenant
Audit Right. Landlord shall permit Tenant, at Tenant’s expense and during normal business hours, but only one time
with respect to any Operating Year, to review Landlord’s invoices and statement relating to the Operating Costs for the
applicable Operating Year for the purpose of verifying the Operating Costs and Tenant’s share thereof; provided that
notice of Tenant’s desire to so review is given to Landlord not later than thirty (30) days after Tenant receives an
annual statement from Landlord, and provided that such review is thereafter commenced and prosecuted by Tenant with due
diligence. Any Operating Costs statement or accounting by Landlord shall be binding and conclusive upon Tenant unless (i)
Tenant duly requests such review within such 30-day period, and (ii) within three (3) months after such review request,
Tenant shall notify Landlord in writing that Tenant disputes the correctness of such statement, specifying the particular
respects in which the statement is claimed to be incorrect. Tenant shall have no right to conduct a review or to give
Landlord notice that it desires to conduct a review at any time Tenant is in default under the Lease. The accountant
conducting the review shall (i) be a qualified lease auditor approved by Landlord (such approval not to be unreasonably
withheld) having at least five (5) years applicable experience, and (ii) be compensated on an hourly basis and shall not be
compensated based upon a percentage of overcharges it discovers. No subtenant shall have any right to conduct a review, and
no assignee shall conduct a review for any period during which such assignee was not in possession of the Premises. Tenant
agrees that all information obtained from any such Operating Costs review, including without limitation, the results of any
Operating Costs review shall be kept strictly confidential by Tenant and shall not be disclosed to any other person or
entity. If the audit shows that Tenant has overpaid with respect to Operating Costs for an Operating Year then, then, absent
a good faith challenge by Landlord to such results, Landlord shall reimburse any such overpayment to Tenant. If the
audit shows that Tenant has underpaid with respect to Operating Costs for an Operating Year Tenant shall reimburse Landlord
for such underpayment.

 

    	-13-

    	 

    

 

10.         CHANGES
OR ALTERATIONS BY LANDLORD

 

Subject to Section 17.2 below with respect to
entry into the Premises, Landlord reserves the right, exercisable by itself or its nominee, at any time and from time to time without
the same constituting an actual or constructive eviction and without incurring any liability to Tenant therefor or otherwise affecting
Tenant’s obligations under this Lease, to make such changes, alterations, additions, improvements, repairs or replacements
in or to: (i) the Building (including the Premises) and the fixtures and equipment thereof, (ii) the street entrances, halls, passages,
elevators, escalators, and stairways of the Building, and (iii) the Common Areas, and facilities located therein, as Landlord may
deem necessary or desirable, and to change the arrangement and/or location of entrances or passageways, doors and doorways, and
corridors, elevators, stairs, toilets, or other public parts of the Building and/or the Common Areas, provided, however, that there
be no unreasonable obstruction of the right of access to, or unreasonable interference with the use and enjoyment of, the Premises
by Tenant. Nothing contained in this Article 10 shall be deemed to relieve Tenant of any duty, obligation or liability of Tenant
with respect to making any repair, replacement or improvement or complying with any law, order or requirement of any governmental
or other authority. Landlord reserves the right to adopt and at any time and from time to time to change the name or address of
the Building. Neither this Lease nor any use by Tenant shall give Tenant any right or easement for the use of any door, passage,
concourse, walkway or parking area within the Building or in the Common Areas, and the use of such doors, passages, concourses,
walkways, parking areas and such conveniences may be regulated or discontinued at any time and from time to time by Landlord without
notice to Tenant and without affecting the obligation of Tenant hereunder or incurring any liability to Tenant therefor, provided,
however, that there be no unreasonable obstruction of the right of access to, or unreasonable interference with the use of the
Premises by Tenant.

 

If at any time any windows of the Premises are
temporarily closed or darkened for any reason whatsoever including but not limited to, Landlord’s own acts, Landlord shall
not be liable for any damage Tenant may sustain thereby and Tenant shall not be entitled to any compensation therefor nor abatements
of rent nor shall the same release Tenant from its obligations hereunder nor constitute an eviction.

 

11.         FIXTURES,
EQUIPMENT AND IMPROVEMENTS-REMOVAL BY TENANT

 

All fixtures (excluding trade fixtures installed
by or on behalf of Tenant), equipment (excluding trade equipment installed by or on behalf of Tenant), improvements and appurtenances
attached to or built into the Premises prior to or during the term, whether by Landlord at its expense or at the expense of Tenant
(either or both) or by Tenant shall be and remain part of the Premises and shall not be removed by Tenant during or at the end
of the term unless Landlord otherwise elects to require Tenant to remove such fixtures, equipment, improvements and appurtenances,
in accordance with Articles 12 and/or 22 of the Lease. All electric, telephone, telegraph, communication, radio, plumbing, heating
and sprinkling systems, fixtures and outlets, vaults, paneling, molding, shelving, radiator enclosures, cork, rubber, linoleum
and composition floors, ventilating, silencing, air conditioning and cooling equipment, shall be deemed to be included in such
fixtures, equipment, improvements and appurtenances, whether or not attached to or built into the Premises. Where not built into
the Premises, all of Tenant’s removable electric fixtures, carpets, drinking or tap water facilities, furniture, or trade
fixtures or business or laboratory equipment or Tenant’s inventory or stock in trade shall not be deemed to be included in
such fixtures, equipment, improvements and appurtenances and may be, and upon the request of Landlord as set forth above, will
be removed by Tenant upon the condition that such removal shall not materially damage the Premises or the Building and that the
cost of repairing any damage to the Premises or the Building arising from installation or such removal shall be paid by Tenant.
The covenants of this Section shall survive the expiration or earlier termination of the Term.

 

    	-14-

    	 

    

 

12.         ALTERATIONS
AND IMPROVEMENTS BY TENANT

 

Tenant shall make no alterations, decorations,
installations, removals, additions or improvements in or to the Premises without Landlord’s prior written consent and unless
made by contractors or mechanics approved by Landlord. No installations or work shall be undertaken or begun by Tenant until: (i)
Landlord has approved written plans and specifications and a time schedule for such work; (ii) Tenant has made provision for either
written waivers of liens from all contractors, laborers and suppliers of materials for such installations or work, the filing of
lien bonds on behalf of such contractors, laborers and suppliers, or other appropriate protective measures approved by Landlord;
and (iii) Tenant has procured appropriate surety payment and performance bonds. No amendments or additions to such plans and specifications
shall be made without the prior written consent of Landlord. Landlord’s consent and approval required under this Article
12 shall not be unreasonably withheld, conditioned or delayed. Landlord’s approval is solely given for the benefit of Landlord
and neither Tenant nor any third party shall have the right to rely upon Landlord’s approval of Tenant’s plans for
any purpose whatsoever. Without limiting the foregoing, Tenant shall be responsible for all elements of the design of Tenant’s
plans (including, without limitation, compliance with law, functionality of design, the structural integrity of the design, the
configuration of the Premises and the placement of Tenant’s furniture, appliances and equipment), and Landlord’s approval
of Tenant’s plans shall in no event relieve Tenant of the responsibility for such design. Landlord shall have no liability
or responsibility for any claim, injury or damage alleged to have been caused by the particular materials, whether building standard
or non-building standard, appliances or equipment selected by Tenant in connection with any work performed by or on behalf of Tenant
in the Premises including, without limitation, furniture, carpeting, copiers, laser printers, computers and refrigerators. Any
such work, alterations, decorations, installations, removals, additions and improvements shall be done at Tenant’s sole expense
and at such times and in such manner as Landlord may from time to time designate. If Tenant shall make any alterations, decorations,
installations, removals, additions or improvements, then Landlord may elect, at the time consent thereto is requested and granted,
to require the Tenant at the expiration or sooner termination of the term of this Lease to restore the Premises to substantially
the same condition as existed at the Term Commencement Date. Tenant shall pay, as an additional charge, the entire increase in
real estate taxes on the Building which shall, at any time prior to or after the Term Commencement Date, result from or be attributable
to any alteration, addition or improvement to the Premises made by or for the account of Tenant.

 

If, as a result of any
alterations, decorations, installations, removals, additions and improvements made by Tenant, Landlord is obligated to comply with
the Americans With Disabilities Act or any other federal, state or local laws or regulations and such compliance requires Landlord
to make any improvement or alteration to any portion of the Building or the Complex, as a condition to Landlord’s consent,
Landlord shall have the right to require Tenant to pay to Landlord prior to the construction of any such alteration, decoration,
installation, removal, addition or improvement by Tenant, the entire cost of any improvement or alteration Landlord is obligated
to complete by such law or regulation.

 

Without limiting any of the terms hereof, Landlord
will not approve any alteration, decoration, installation, removal, addition or improvement requiring unusual expense to readapt
the Premises to normal office use on lease termination or increasing the cost of construction, insurance or Taxes on the Building
or of Landlord’s services to the Premises, unless Tenant first gives assurances or security acceptable to Landlord that such
re-adaptation will be made prior to such termination without expense to Landlord and makes provisions acceptable to Landlord for
payment of such increased cost.

 

Notwithstanding the forgoing, Tenant shall have
the right, upon prior written notice to Landlord, but without the necessity of obtaining Landlord’s consent, to make interior,
nonstructural alterations to the Premises that (a) cost less than $10,000 in the aggregate in any calendar year, (b) do not materially
or adversely affect any fire, safety, telecommunication, electrical, mechanical, ventilation, plumbing or other systems of the
Building, (c) do not cause any material penetration in or otherwise affect any walls, floors, roofs or other structural elements
of the Building, (d) do not require the issuance of any permits, licenses, approvals or the like, and (e) do not require unusual
expense to readapt the Premises to normal laboratory use at the termination, provided that all work shall be done by contractors
reasonably approved by Landlord and otherwise in accordance with the terms of this Lease.

 

13.         TENANT’S
CONTRACTORS-MECHANICS’ AND OTHER LIENS-STANDARD OF TENANT’S PERFORMANCE-COMPLIANCE WITH LAWS

 

Whenever Tenant shall make any alterations,
decorations, installations, removals, additions or improvements in or to the Premises—whether such work be done prior to
or after the Term Commencement Date—Tenant will strictly observe the following covenants and agreements:

 

    	-15-

    	 

    

 

(a)          Tenant
agrees that it will not, either directly or indirectly, use any contractors and/or materials if their use will create any difficulty,
whether in the nature of a labor dispute or otherwise, with other contractors and/or labor engaged by Tenant or Landlord or others
in the construction, maintenance and/or operation of the Building or any part thereof.

 

(b)          In
no event shall any material or equipment be incorporated in or added to the Premises, so as to become a fixture or otherwise a
part of the Building, in connection with any such alteration, decoration, installation, addition or improvement which is subject
to any lien, charge, mortgage or other encumbrance of any kind whatsoever or is subject to any security interest or any form of
title retention agreement. No installations or work shall be undertaken or begun by Tenant until (i) Tenant has made provision
for written waiver of liens from all contractors, laborers and suppliers of materials for such installations or work, and taken
other appropriate protective measures approved by Landlord; and (ii) Tenant has procured appropriate surety payment and performance
bonds which shall name Landlord as an additional obligee and has filed lien bond(s) (in jurisdictions where available) on behalf
of such contractors, laborers and suppliers. Any mechanic’s lien filed against the Premises or the Building for work claimed
to have been done for, or materials claimed to have been furnished to, Tenant shall be discharged by Tenant within ten (10) days
thereafter, at Tenant’s expense by filing the bond required by law or otherwise. If Tenant fails so to discharge any lien,
Landlord may do so at Tenant’s expense and Tenant shall reimburse Landlord for any expense or cost incurred by Landlord in
so doing within fifteen (15) days after rendition of a bill therefor.

 

(c)          All
installations or work done by Tenant shall be at its own expense and shall at all times comply with (i) laws, rules, orders and
regulations of governmental authorities having jurisdiction thereof; (ii) orders, rules and regulations of any Board of Fire Underwriters,
or any other body hereafter constituted exercising similar functions, and governing insurance rating bureaus; (iii) Rules and Regulations
of Landlord; and (iv) plans and specifications prepared by and at the expense of Tenant theretofore submitted to and approved by
Landlord.

 

(d)          Tenant
shall procure and deliver to Landlord copies of all necessary permits before undertaking any work in the Premises; do all of such
work in a good and workmanlike manner, employing materials of good quality and complying with all governmental requirements; and
defend, save harmless, exonerate and indemnify Landlord from all injury, loss or damage to any person or property occasioned by
or growing out of such work. Tenant shall cause contractors employed by Tenant to carry Worker’s Compensation Insurance in
accordance with statutory requirements, Automobile Liability Insurance and, naming Landlord as an additional insured, Commercial
General Liability insurance covering such contractors on or about the Premises in the amounts stated in Article 15 hereof or in
such other reasonable amounts as Landlord shall require and to submit certificates evidencing such coverage to Landlord prior to
the commencement of such work.

 

14.         REPAIRS
BY TENANT-FLOOR LOAD

 

14.1         Repairs
by Tenant. Tenant shall keep all and singular the Premises neat and clean (including periodic rug shampoo and waxing of tiled
floors and cleaning of blinds and drapes) and in such repair, order and condition as the same are in on the Term Commencement Date
or may be put in during the term hereof, reasonable use and wearing thereof and damage by fire or by other casualty excepted. For
purposes of this Lease, the terms “reasonable use and wearing” and “ordinary wear and use” (as referred
to in Article 22 herein) constitute that normal, gradual deterioration which occurs due to aging and ordinary use of the Premises
despite reasonable and timely maintenance and repair, but in no event shall the aforementioned terms excuse Tenant from its duty
to keep the Premises in good maintenance and repair or otherwise usable, serviceable and tenantable as required in the Lease. Tenant
shall be solely responsible for the proper maintenance of all equipment and appliances operated by Tenant, including, without limitation,
copiers, laser printers, computers and refrigerators and the Generator. Tenant shall be responsible for janitorial services to
be provided to the Premises including any bathrooms located within the Premises. Tenant shall make, as and when needed as a result
of misuse by, or neglect or improper conduct of, Tenant or Tenant’s servants, employees, agents, contractors, invitees, or
licensees or otherwise, all repairs in and about the Premises necessary to preserve them in such repair, order and condition, which
repairs shall be in quality and class equal to the original work. Landlord may elect, at the expense of Tenant, to make any such
repairs or to repair any damage or injury to the Building or the Premises caused by moving property of Tenant in or out of the
Building, or by installation or removal of furniture or other property, or by misuse by, or neglect, or improper conduct of, Tenant
or Tenant’s servants, employees, agents, contractors, or licensees.

 

    	-16-

    	 

    

 

14.2         Floor
Load-Heavy Machinery. Tenant shall not place a load upon any floor of the Premises exceeding the floor load per square foot
of area which such floor was designed to carry and which is allowed by law. Landlord reserves the right to prescribe the weight
and position of all business machines and mechanical equipment, including safes, which shall be placed so as to distribute the
weight. Business machines and mechanical equipment shall be placed and maintained by Tenant at Tenant’s expense in settings
sufficient in Landlord’s judgment to absorb and prevent vibration, noise and annoyance. Tenant shall not move any safe, heavy
machinery, heavy equipment, freight, bulky matter, or fixtures into or out of the Building without Landlord’s prior written
consent. If such safe, machinery, equipment, freight, bulky matter or fixtures requires special handling, Tenant agrees to employ
only persons holding a Master Rigger’s License to do said work, and that all work in connection therewith shall comply with
applicable laws and regulations. Any such moving shall be at the sole risk and hazard of Tenant and Tenant will defend, indemnify
and save Landlord harmless against and from any liability, loss, injury, claim or suit resulting directly or indirectly from such
moving. Proper placement of all such business machines, etc., in the Premises shall be Tenant’s responsibility.

 

15.         INSURANCE,
INDEMNIFICATION, EXONERATION AND EXCULPATION

 

15.1       General
Liability Insurance. During the term of this Lease, Tenant shall procure, and keep in force and pay for:

 

(a)          Commercial
General Liability Insurance insuring Tenant on an occurrence basis against all claims and demands for personal injury liability
(including, without limitation, bodily injury, sickness, disease, and death) or damage to property which may be claimed to have
occurred from and after the time Tenant and/or its contractors enter the Premises in accordance with Article 4 of this Lease, of
not less than Five Million ($5,000,000) Dollars in the event of personal injury to any number of persons or damage to property,
arising out of any one occurrence, and contain the “Amendment of the Pollution Exclusion” for damage caused by heat,
smoke or fumes from a hostile fire. The policy shall not contain any intra-insured exclusions as between insured persons or organizations,
but shall include coverage for liability assumed under this Lease as an “insured contract” for the performance of Tenant’s
indemnity obligations under this Lease. Landlord may from time to time during the term increase the coverages required of Tenant
hereunder to that customarily carried in the area in which the Premises are located on property similar to the Premises.

 

(b)          Workers’
Compensation in amounts required by the State in which the Building is located and Employer's Liability insurance in the amount
of $3,000,000. per occurrence.

 

(c)          Tenant
shall obtain and maintain loss of income and extra expense insurance in amounts as will reimburse Tenant for direct or indirect
loss of earnings attributable to all peril commonly insured against by prudent lessees in the business of Tenant or attributable
to prevention of access to the Premises as a result of such perils.

 

(d)          So
called “Special Form” insurance coverage for all of its contents, furniture, furnishings, equipment, improvements,
fixtures and personal property located at the Premises providing protection in an amount equal to one hundred percent (100%) of
the replacement cost basis of said items. If this Lease is terminated as the result of a casualty in accordance with Section 18,
the proceeds of said insurance attributable to the replacement of all tenant improvements installed at the Premises by Landlord
or at Landlord’s cost shall be paid to Landlord.

 

    	-17-

    	 

    

 

(e)          Any
other form or forms of insurance as Tenant or Landlord or any mortgagees of Landlord may reasonably require from time to time in
form, in amounts and for insurance risks against which a prudent tenant would protect itself.

 

15.2       Certificates
of Insurance. Such insurance shall be effected with insurers approved by Landlord, authorized to do business in the State wherein
the Building is situated under valid and enforceable policies wherein Tenant names Landlord, Landlord’s managing agent and
Landlord’s Mortgagees as additional insureds. Such insurance shall provide that it shall not be canceled or modified without
at least thirty (30) days’ prior written notice to each insured named therein. On or before the time Tenant and/or its contractors
enter the Premises in accordance with Articles 4 and 14 of this Lease and thereafter not less than fifteen (15) days prior to the
expiration date of each expiring policy, original copies of the policies provided for in Article 15.1 issued by the respective
insurers, or certificates of such policies setting forth in full the provisions thereof and issued by such insurers together with
evidence satisfactory to Landlord of the payment of all premiums for such policies, shall be delivered by Tenant to Landlord and
certificates as aforesaid of such policies shall upon request of Landlord, be delivered by Tenant to the holder of any mortgage
affecting the Premises.

 

15.3       General.
Tenant will save Landlord, its agents and employees, harmless and will exonerate, defend and indemnify Landlord, its agents and
employees, from and against any and all claims, liabilities or penalties asserted by or on behalf of any person, firm, corporation
or public authority arising from the Tenant’s breach of the Lease or;

 

(a)          On
account of or based upon any injury to person, or loss of or damage to property, sustained or occurring on the Premises on account
of or based upon the act, omission, fault, negligence or misconduct of any person whomsoever (except to the extent the same is
caused by the negligence or willful misconduct of Landlord, its agents, contractors or employees, or as otherwise expressly required
by law);

 

(b)          On
account of or based upon any injury to person, or loss of or damage to property, sustained or occurring elsewhere (other than on
the Premises) in or about the Building (and, in particular, without limiting the generality of the foregoing, on or about the elevators,
stairways, public corridors, sidewalks, concourses, arcades, malls, galleries, vehicular tunnels, approaches, areaways, roof, or
other appurtenances and facilities used in connection with the Building or Premises) arising out of the use or occupancy of the
Building or Premises by the Tenant, or by any person claiming by, through or under Tenant, or on account of or based upon the act,
omission, fault, negligence or misconduct of Tenant, its agents, employees or contractors;

 

(c)          On
account of or based upon (including monies due on account of) any work or thing whatsoever done (other than by Landlord or its
contractors, or agents or employees of either) on the Premises during the term of this Lease and during the period of time, if
any, prior to the Term Commencement Date that Tenant may have been given access to the Premises; and

 

(d)          Tenant’s
obligations under this Article 15.3 shall be insured either under the Commercial General Liability Insurance required under Article
15 J, above, or by a contractual insurance rider or other coverage; and certificates of insurance in respect thereof shall be provided
by Tenant to Landlord upon request.

 

15.4       Property
of Tenant. In addition to and not in limitation of the foregoing, Tenant covenants and agrees that, to the maximum extent permitted
by law, all merchandise, furniture, fixtures and property of every kind, nature and description related or arising out of Tenant’s
leasehold estate hereunder, which may be in or upon the Premises or Building, in the public corridors, or on the sidewalks, areaways
and approaches adjacent thereto, shall be at the sole risk and hazard of Tenant, and that if the whole or any part thereof shall
be damaged, destroyed, stolen or removed from any cause or reason whatsoever, no part of said damage or loss shall be charged to,
or borne by, Landlord.

 

    	-18-

    	 

    

 

15.5         Bursting
of Pipes, etc. Landlord shall not be liable for any injury or damage to persons or property resulting from fire, explosion,
falling plaster, steam, gas, air contaminants or emissions, electricity, electrical or electronic emanations or disturbance, water,
rain or snow or leaks from any part of the Building or from the pipes, appliances, equipment or plumbing works or from the roof,
street or subsurface or from any other place or caused by dampness, vandalism, malicious mischief or by any other cause of whatever
nature, unless caused by or due to the negligence or willful misconduct of Landlord, its agents, servants or employees, and then
only after (i) notice to Landlord of the condition claimed to constitute negligence or willful misconduct and (ii) the expiration
of a reasonable time after such notice has been received by Landlord without Landlord having taken all reasonable and practicable
means to cure or correct such condition; and pending such cure or correction by Landlord, Tenant shall take all reasonably prudent
temporary measures and safeguards to prevent any injury, loss or damage to persons or property. In no event shall Landlord be liable
for any loss, the risk of which is covered by Tenant’s insurance or is required to be so covered by this Lease; nor shall
Landlord or its agents be liable for any such damage caused by other tenants or persons in the Building or caused by operations
in construction of any private, public, or quasi-public work; nor shall Landlord be liable for any latent defect in the Premises
or in the Building.

 

15.6         Repairs
and Alterations-No Diminution of Rental Value. Except as otherwise provided in Article 18, there shall be no allowance to Tenant
for diminution of rental value and no liability' on the part of Landlord by reason of inconvenience, annoyance or injury to Tenant
arising from any repairs, alterations, additions, replacements or improvements made by Landlord, or any related work, Tenant or
others in or to any portion of the Building or Premises or any property adjoining the Building, or in or to fixtures, appurtenances,
or equipment thereof, or for failure of Landlord or others to make any repairs, alterations, additions or improvements in or to
any portion of the Building, or of the Premises, or in or to the fixtures, appurtenances or equipment thereof.

 

15.7         Landlord
Insurance. Landlord shall maintain and keep in effect throughout the Term of this Lease (a) insurance against loss or damage
to the Building by fire or other casualty as may be included within either fire and extended coverage insurance or "special
form" insurance in commercially reasonable amounts, or such other coverages, amounts and/or endorsements as Landlord determines
in its sole but good faith judgment, (b) commercial general liability insurance in amounts determined by Landlord in its sole but
good faith judgment, and (c) such other insurance coverages and policies as Landlord determines in its sole but good faith judgment.
Any such coverages may be effected directly and/or through the use of blanket insurance coverage covering more than one location
and may contain such commercially reasonable deductibles as Landlord may elect in its reasonable discretion. The cost of all such
insurance shall be included as part of Operating Costs.

 

16.         ASSIGNMENT,
MORTGAGING AND SUBLETTING

 

16.1         Generally.(a)
Tenant covenants and agrees that neither this Lease nor the term and estate hereby granted, nor any interest herein or therein,
will be assigned, sublet, mortgaged, pledged, encumbered or otherwise transferred, voluntarily, by operation of law or otherwise,
and that neither the Premises, nor any part thereof will be encumbered in any manner by reason of any act or omission on the part
of Tenant, or used or occupied, or permitted to be used or occupied, or utilized for desk space or for mailing privileges, by anyone
other than Tenant, or for any use or purpose other than as stated in Exhibit I, or be sublet, or offered or advertised for subletting.
Notwithstanding the foregoing, Tenant may assign or sublet (which term, without limitation, shall include the granting of any concessions,
licenses, occupancy rights, management arrangements and the like) the whole or any part of the Premises with, in each instance,
having first received the express, written consent of Landlord, which consent shall not be unreasonably withheld, delayed or conditioned.

 

    	-19-

    	 

    

 

(b)          Without
limitation, it shall not be unreasonable for Landlord to withhold such approval from any assignment or subletting where, in Landlord’s
opinion: (i) the proposed assignee or sublessee does not have a financial standing and credit rating reasonably acceptable to Landlord;
(ii) the business in which the proposed assignee or sublessee is engaged could detract from the Building, its value or the costs
of ownership thereof; (iii) intentionally omitted; (iv) the proposed sublessee or assignee is a current tenant or a prospective
tenant (meaning such tenant, within the past six (6) months preceding the request for an assignment or sublease) has been shown
or has been presented with or has made an offer to lease space) of the Building; (v) the use of the Premises by any sublessee or
assignee (even though a Permitted Use) violates any use restriction granted by Landlord in any other lease or would otherwise cause
Landlord to be in violation of its obligations under another lease or agreement to which Landlord is a party; (vi) if such assignment
or subleasing is not approved of by the holder of any mortgage on the Building (if such approval is required); (vii) a proposed
assignee’s or subtenant’s business will impose a burden on the Building’s parking facilities, elevators, common
areas, facilities, or utilities that is greater than the burden imposed by Tenant, in Landlord’s reasonable judgment; (viii)
any guarantor of this Lease refuses to consent to the proposed transfer or to execute a written agreement reaffirming the guaranty;
(ix) Tenant is in default of any of its obligations under the Lease at the time of the request or at the time of the proposed assignment
or sublease, each beyond any applicable notice or cure period; (x) if requested by Landlord, the assignee or subtenant refuses
to sign a non-disturbance and attornment agreement in favor of Landlord’s lender; (xi) Landlord has sued or been sued by
the proposed assignee or subtenant or has otherwise been involved in a legal dispute with the proposed assignee or subtenant; (xii)
the assignee or subtenant is involved in a business which is not in keeping with the then current standards of the Building; (xiii)
the assignment or sublease will result in there being more than one (1) subtenant of the Premises (e.g., the assignee or subtenant
intends to use the Premises as an executive suite); or (xiv) the assignee or subtenant is a governmental or quasi-governmental
entity or an agency, department or instrumentality of a governmental or quasi-governmental agency. Landlord may condition its consent
upon such assignee or sublessee depositing with Landlord such additional security as Landlord may reasonably require to assure
the performance and observance of the obligations of such party to Landlord. In no event, however, shall Tenant assign this Lease
or sublet the whole or any part of the Premises to a proposed assignee or sublessee which has been judicially declared bankrupt
or insolvent according to law, or with respect to which an assignment has been made of property for the benefit of creditors, or
with respect to which a receiver, guardian, conservator, trustee in involuntary bankruptcy or similar officer has been appointed
to take charge of all or any substantial part of the proposed assignee’s or sublessee’s property by a court of competent
jurisdiction, or with respect to which a petition has been filed for reorganization under any provisions of the Bankruptcy Code
now or hereafter enacted, or if a proposed assignee or sublessee has filed a petition for such reorganization, or for arrangements
under any provisions of the Bankruptcy Code now or hereafter enacted and providing a plan for a debtor to settle, satisfy or extend
the time for the payment of debts.

 

(c)          Any
request by Tenant for such consent shall set forth or be accompanied by, in detail reasonably satisfactory to Landlord, the identification
of the proposed assignee or sublessee, its financial condition and the terms on which the proposed assignment or subletting is
to be made, including, without limitation, a signed copy of all assignment and sublease documents, and clearly stating the rent
or any other consideration to be paid in respect thereto; and such request shall be treated as Tenant’s warranty in respect
of the information submitted therewith. Tenant’s request shall not be deemed complete or submitted until all of the foregoing
information has been received by Landlord. Landlord shall respond to such request for consent within thirty (30) days following
Landlord’s receipt of all information, documentation and security required by Landlord with respect to such proposed sublease
or assignment.

 

(d)          The
foregoing restrictions shall be binding on any assignee or sublessee to which Landlord has consented, provided, notwithstanding
anything else contained in this Lease, Landlord’s consent to any further assignment, subleasing or any sub-subleasing by
any approved assignee or sublessee may be withheld by Landlord at Landlord’s sole and absolute discretion.

 

(e)          Consent
by Landlord to any assignment or subleasing shall not include consent to the assignment or transferring of any lease renewal, extension
or other option, first offer, first refusal or other rights granted hereunder, or any special privileges or extra services granted
to tenant by separate agreement (written or oral), or by addendum or amendment of the Lease.

 

    	-20-

    	 

    

 

(f)          In
the case of any assignment of this Lease or subletting of the Premises, the Tenant named herein shall be and remain fully and primarily
liable for the obligations of Tenant hereunder, notwithstanding such assignment or subletting, including, without limitation, the
obligation to pay the Yearly Rent and other amounts provided under this Lease, and the Tenant shall be deemed to have waived all
suretyship defenses.

 

(g)          In
addition to the foregoing, it shall be a condition of the validity of any such assignment or subletting that the assignee or sublessee
agrees directly with Landlord, in form satisfactory to Landlord, to be bound by all the obligations of Tenant hereunder, including,
without limitation, the obligation to pay Yearly Rent and other amounts provided for under this Lease, the covenant regarding use
and the covenant against further assignment and subletting.

 

16.2       Reimbursement,
Recapture and Excess Rent.

 

(a)          Tenant
shall, upon demand, reimburse Landlord for the reasonable fees and expenses (including reasonable legal and administrative fees
and costs) incurred by Landlord in processing any request to assign this Lease or to sublet all or any portion of the Premises,
whether or not Landlord agrees thereto, and if Tenant shall fail promptly so to reimburse Landlord, the same shall be a default
in Tenant’s monetary obligations under this Lease subject to the applicable grace and cure period set forth in Article 21.

 

(b)          If
Tenant requests Landlord’s consent to assign this Lease or sublet (or otherwise grant occupancy rights in and to) all or
a portion of the Premises, Landlord shall have the option, exercisable by written notice to Tenant given within thirty (30) days
after Landlord’s receipt of Tenant’s completed request, to terminate this Lease as of the date specified in such notice,
which shall not be less than thirty (30) nor more than one hundred twenty (120) days after the date of such notice, as to the entire
Premises in the case of a proposed assignment or subletting of the whole Premises, and as to the portion of the Premises to be
sublet in the case of a subletting of a portion. In the event of termination in respect of a portion of the Premises, the portion
so eliminated shall be delivered to Landlord on the date specified in good order and condition in the manner provided in this Lease
at the end of the Term and thereafter, to the extent necessary in Landlord’s judgment, Landlord, at its own cost and expense,
may have access to and may make modification to the Premises (or portion thereof) so as to make such portion a self-contained rental
unit with access to common areas, elevators and the like. Yearly Rent and the Total Rentable Area of the Premises shall be adjusted
according to the extent of the Premises for which the Lease is terminated.

 

(c)          Without
limitation of the rights of Landlord hereunder in respect thereto, if there is any assignment of this Lease by Tenant for consideration
or a subletting of the whole of the Premises by Tenant at a rent which exceeds the rent payable hereunder by Tenant, or if there
is a subletting of a portion of the Premises by Tenant at a rent in excess of the subleased portion’s pro rata share of the
rent payable hereunder by Tenant, then Tenant shall pay to Landlord, as additional rent, forthwith upon Tenant’s receipt
of, in the case of an assignment, one-half (1/2) of all of the consideration (or the cash equivalent thereof) therefor which exceeds
the rent payable hereunder by Tenant and in the case of a subletting, one-half (1/2) of all of any such excess rent. For the purposes
of this subsection, the term “rent" shall mean all Yearly Rent, additional rent or other payments and/or consideration
payable by one party to another for the use and occupancy of all or a portion of the Premises including, without limitation, key
money, or bonus money paid by the assignee or subtenant to Tenant in connection with such transaction and any payment in excess
of fair market value for services rendered by Tenant to the assignee or subtenant or for assets, fixtures, inventory, equipment
or furniture transferred by Tenant to the assignee or subtenant in connection with any such transaction, but shall exclude any
separate payments by Tenant for reasonable attorney’s fees, reasonable broker’s commissions architectural and engineering
fees, lease takeover payments, costs of advertising the space for sublease or assignment and the unamortized cost of initial and
subsequent improvements to the Premises made by Tenant, and leasehold improvements paid for by Tenant in connection with such assignment
or subletting.

 

    	-21-

    	 

    

 

(d)          If
the Premises or any part thereof are sublet by Tenant, following the occurrence of a default which has continued beyond the applicable
cure period, Landlord, in addition to any other remedies provided hereunder or at law, may at its option collect directly from
such sublessee(s) all rents becoming due to the Tenant under such sublease(s) and apply such rent against any amounts due Landlord
by Tenant under this Lease, and Tenant hereby irrevocably authorizes and directs such sublessee(s) to so make all such rent payments,
if so directed by Landlord; and it is understood that no such election or collection or payment shall be construed to constitute
a novation of this Lease or a release of Tenant hereunder, or to create any lease or occupancy agreement between the Landlord and
such subtenant or impose any obligations on Landlord, or otherwise constitute the recognition of such sublease by Landlord for
any purpose whatsoever.

 

(e)          The
following terms and conditions shall apply to any subletting by Tenant of all or any part of the Premises and shall be deemed included
in all subleases under this Lease whether or not expressly incorporated therein:

 

Tenant hereby absolutely and unconditionally assigns and transfers
to Landlord all of Tenant’s interest in all rentals and income arising from any sublease entered into by Tenant, and Landlord
may collect such rent and income and apply same toward Tenant’s obligations under this Lease; provided, however, that until
a default occurs in the performance of Tenant’s obligations under this Lease, Tenant may receive, collect and enjoy the rents
accruing under such sublease. Landlord shall not, by reason of this or any other assignment of such rents to Landlord nor by reason
of the collection of the rents from a subtenant, be deemed to have assumed or recognized any sublease or to be liable to the subtenant
for any failure of Tenant to perform and comply with any of Tenant’s obligations to such subtenant under such sublease, including,
but not limited to, Tenant’s obligation to return any security deposit. Tenant hereby irrevocably authorizes and directs
any such subtenant, upon receipt of a written notice from Landlord stating that a default exists in the performance of Tenant’s
obligations under this Lease, to pay to Landlord the rents due as they become due under the sublease. Tenant agrees that such subtenant
shall have the right to rely upon any such statement and request from Landlord, and that such subtenant shall pay such rents to
Landlord without any obligation or right to inquire as to whether such default exists and notwithstanding any notice from or claim
from Tenant to the contrary. In the event Tenant shall default in the performance of its obligations under this Lease or Landlord
terminates this Lease by reason of a default of Tenant, Landlord at its option and without any obligation to do so, may require
any subtenant to attorn to Landlord, in which event Landlord shall undertake the obligations of Tenant under such sublease from
the time of the exercise of said option to the termination of such sublease; provided, however, Landlord shall not be liable for
any prepaid rents or security deposit paid by such subtenant to Tenant or for any other prior defaults of Tenant under such sublease.

 

16.3         Certain
Transfers/Miscellaneous.

 

Notwithstanding any other provision of this
Article 16, transactions with an entity (i) into or with which Tenant is merged or consolidated, (ii) to which substantially all
of Tenant’s assets are transferred as a going concern, or (iii) which controls or is controlled by Tenant or is under common
control with Tenant, shall not be deemed to be an assignment or subletting within the meaning of this Article, provided that in
any of such events (1) Landlord receives prior written notice of any such transactions, (2) the assignee or subtenant agrees directly
with Landlord, by written instrument in form satisfactory to Landlord, to be bound by all the obligations of Tenant hereunder including,
without limitation, the covenant against further assignment and subletting, (3) in no event shall Tenant be released from its obligations
under this Lease, (4) any such transfer or transaction is for a legitimate, regular business purpose of Tenant other than a transfer
of Tenant’s interest in this Lease, and (5) the involvement by Tenant or its assets in any transaction, or series of transactions
(by way of merger, sale, acquisition, financing, refinancing, transfer, leveraged buyout or otherwise) whether or not a formal
assignment or hypothecation of this Lease or Tenant’s assets occurs, will not result in a reduction of the “‘Net
Worth of Tenant as hereinafter defined, below an amount equal to such Net Worth of Tenant as it is represented to Landlord at the
time of the execution by Landlord of this Lease, or as it exists immediately prior to said transaction or transactions constituting
such reduction, at whichever time said Net Worth of Tenant was or is greater. “Net Worth” of Tenant for purposes of
this section shall be the net worth and liquidity of Tenant (excluding any guarantors) established under generally accepted accounting
principles consistently applied.

 

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The listing of any name other than that of Tenant,
whether on the doors of the Premises or on the Building directory, or otherwise, shall not operate to vest in any such other person,
firm or corporation any right or interest in this Lease or in the Premises or be deemed to effect or evidence any consent of Landlord,
it being expressly understood that any such listing is a privilege extended by Landlord revocable at will by written notice to
Tenant.

 

Any consent by Landlord to a particular assignment
or subletting shall not in any way diminish the prohibition stated in the first sentence of this Article 16 or the continuing liability
of the Tenant named on Exhibit 1 as the party Tenant under this Lease. No assignment or subletting shall affect the purpose for
which the Premises may be used as stated in Exhibit 1.

 

17.         MISCELLANEOUS
COVENANTS

 

Tenant covenants and agrees as follows:

 

17.1         Rules
and Regulations. Tenant will faithfully observe and comply with the Rules and Regulations, if any, annexed hereto and such
other and further reasonable Rules and Regulations as Landlord hereafter at any time or from time to time may make and may communicate
in writing to Tenant, which in the reasonable judgment of Landlord shall be necessary for the reputation, safety, care or appearance
of the Building, or the preservation of good order therein, or the operation or maintenance of the Building, or the equipment
thereof, or the comfort of tenants or others in the Building, provided, however, that in the case of any conflict between the
provisions of this Lease and any such regulations, the provisions of this Lease shall control, and provided further that nothing
contained in this Lease shall be construed to impose upon Landlord any duty or obligation to enforce the Rules and Regulations
or the terms, covenants or conditions in any other lease as against any other tenant and Landlord shall not be liable to Tenant
for violation of the same by any other tenant or such other tenant’s servants, employees, agents, contractors, visitors,
invitees or licensees.

 

17.2         Access
to Premises-Shoring. Tenant shall: (i) permit Landlord to erect, use and maintain pipes, ducts and conduits in and through
the Premises, provided the same do not materially reduce the floor area or materially adversely affect the appearance thereof;
(ii) upon prior oral notice (except that no notice shall be required in emergency situations), permit Landlord and any mortgagee
of the Building or the Building and land or of the interest of Landlord therein, and any lessor under any ground or underlying
lease, and their representatives, to have free and unrestricted access to and to enter upon the Premises at all reasonable hours
for the purposes of inspection or of making repairs, replacements or improvements in or to the Premises or the Building or equipment
(including, without limitation, sanitary, electrical, heating, air conditioning or other systems) or of complying with all laws,
orders and requirements of governmental or other authority or of exercising any right reserved to Landlord by this Lease (including
the right during the progress of any such repairs, replacements or improvements or while performing work and furnishing materials
in connection with compliance with any such laws, orders or requirements to take upon or through, or to keep and store within,
the Premises all necessary materials, tools and equipment); and (iii) permit Landlord, at reasonable times and upon prior oral
notice, to show the Premises during ordinary business hours to any existing or prospective mortgagee, ground lessor, space lessee,
purchaser, or assignee of any mortgage, of the Building or of the Building and the land or of the interest of Landlord therein,
and during the period of twelve (12) months next preceding the Termination Date to any person contemplating the leasing of the
Premises or any part thereof. If, during the last month of the term, Tenant shall have removed all or substantially all of Tenant’s
property therefrom, Landlord may immediately enter and alter, renovate and redecorate the Premises, without elimination or abatement
of rent, or incurring liability to Tenant for any compensation, and such acts shall have no effect upon this Lease. If Tenant
shall not be personally present to open and permit an entry into the Premises at any time when for any reason an entry therein
shall be necessary or permissible, Landlord or Landlord’s agents may enter the same by a master key, or may forcibly enter
the same in the event of an emergency, without rendering Landlord or such agents liable therefor (if during such entry Landlord
or Landlord's agents shall accord reasonable care to Tenant’s property), and without in any manner affecting the obligations
and covenants of this Lease. Provided that Landlord shall incur no additional expense thereby, Landlord shall exercise its rights
of access to the Premises permitted under any of the terms and provisions of this Lease in such manner as to minimize to the extent
practicable interference with Tenant’s use and occupation of the Premises and, except in the event of emergency circumstances
or in the event of a default by Tenant under the terms of this Lease, Landlord’s entry into the Premises shall be subject
to Tenant’s reasonable security conditions including, but not limited to, reasonable advance notice (which notice may be
oral) to Tenant and Tenant’s right to elect to have a representative of Tenant present at all times during periods of such
access. If an excavation shall be made upon land adjacent to the Premises or shall be authorized to be made, Tenant shall afford
to the person causing or authorized to cause such excavation, license to enter upon the Premises for the purpose of doing such
work as said person shall deem necessary to preserve the Building from injury or damage and to support the same by proper foundations
without any claims for damages or indemnity against Landlord, or diminution or abatement of rent.

 

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17.3         Accidents
to Sanitary and Other Systems. Tenant shall give to Landlord prompt notice of any fire or accident in the Premises or in the
Building and of any damage to, or defective condition in, any part or appurtenance of the Building including, without limitation,
sanitary, electrical, ventilation, heating and air conditioning or other systems located in, or passing through, the Premises of
which it becomes aware. Except as otherwise provided in Articles 18 and 20, and subject to Tenant’s obligations in Article
14, such damage or defective condition shall be remedied by Landlord with reasonable diligence, but if such damage or defective
condition was caused by Tenant or by the employees, licensees, contractors or invitees of Tenant, the cost to remedy the same shall
be paid by Tenant. In addition, all reasonable costs incurred by Landlord in connection with the investigation of any notice given
by Tenant shall be paid by Tenant if the reported damage or defective condition was caused by Tenant or by the employees, licensees,
contractors, or invitees of Tenant. Tenant shall not be entitled to claim any eviction from the Premises or any damages arising
from any such damage or defect unless and until Landlord shall have failed to commence to perform such obligations hereunder relating
to such damage or defect within thirty (30) days, or such additional time as is reasonably required to correct any such default,
after notice by Tenant to Landlord properly specifying wherein Landlord has failed to perform any such obligation; and in case
of a claim of eviction unless such damage or defective condition shall have rendered the Premises untenantable and they shall not
have been made tenantable by Landlord within a reasonable time.

 

17.4         Signs,
Blinds and Drapes. Tenant shall put no signs in any part of the Building except, at Tenant’s sole cost and subject to
Landlord’s prior reasonable approval, on the entrances to the Premises. No signs or blinds may be put on or in any window
or elsewhere if visible from the exterior of the Building, nor may the building standard drapes or blinds be removed by Tenant.
Notwithstanding the foregoing, Landlord shall provide, at its cost, Building standard signage on all tenant directories within
the Complex including the three (3) exterior kiosks located at the pedestrian level entries to the Complex as well as the garage
lobby entrance and elevator lobby directory for the Building. Tenant may hang its own drapes, provided that they shall not in any
way interfere with the building standard drapery or blinds or be visible from the exterior of the Building and that such drapes
are so hung and installed that when drawn, the building standard drapery or blinds are automatically also drawn. Any signs or lettering
in the public corridors or on the doors shall conform to Landlord’s building standard design. Neither Landlord’s name,
nor the name of the Building or Complex of which the Building is a part, or the name of any other structure erected therein shall
be used without Landlord’s consent in any advertising material (except on business stationery or as an address in advertising
matter), nor shall any such name, as aforesaid, be used in any undignified, confusing, detrimental or misleading manner.

 

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17.5         Estoppel
Certificate and Financial Statements. Tenant shall at any time and from time to time upon not less than ten (10) business
days’ prior notice by Landlord to Tenant, execute, acknowledge and deliver to Landlord a statement in writing certifying
that this Lease is unmodified and in full force and effect (or if there have been modifications, that the same is in full force
and effect as modified and stating the modifications), and the dates to which the Yearly Rent and other charges have been paid
in advance, if any, stating whether or not Landlord is in default in performance of any covenant, agreement, term, provision or
condition contained in this Lease and, if so, specifying each such default and such other facts as Landlord may reasonably request,
it being intended that any such statement delivered pursuant hereto may be relied upon by any prospective purchaser of the Building
or of the Building and the land or of any interest of Landlord therein, any mortgagee or prospective mortgagee thereof, any lessor
or prospective lessor thereof, any lessee or prospective lessee thereof, or any prospective assignee of any mortgage thereof.
Time is of the essence in respect of any such requested certificate, Tenant hereby acknowledging the importance of such certificates
in mortgage financing arrangements, prospective sale and the like. In the event Tenant fails to execute and deliver such certificate
to Landlord within such ten (10) business day period, then, in addition to any other rights or remedies Landlord may have hereunder,
upon Tenant’s failure to so respond to a second notice within three (3) business days, Tenant hereby appoints Landlord Tenant’s
attorney-in-fact in its name and behalf to execute such statement if Tenant shall fail to execute such statement within such three
(3) business day period. Within 120 days after the end of Tenant’s fiscal years during the term of this Lease, Tenant agrees
to furnish to Landlord copies of Tenant’s most recent annual, quarterly and monthly financial statements, audited if available
(if such audited financial statement is not available, such financial statement may be certified by an officer (vice president
or higher) of Tenant). The financial statements shall be prepared in accordance with generally accepted accounting principles,
consistently applied. The financial statements shall include a balance sheet and a statement of profit and loss, and the annual
financial statement shall also include a statement of changes in financial position and appropriate explanatory notes. Landlord
may deliver the financial statements to any prospective or existing mortgagee or purchaser of the Building and/or Complex and
Landlord shall make commercially reasonable efforts to provide that such prospective or existing mortgagee or purchaser agrees
to hold such financial statements in confidence.

 

17.6         Prohibited
Materials and Property. Subject to Section 29.11, Tenant shall not bring or permit to be brought or kept in or on the Premises
or elsewhere in the Building (i) any inflammable, combustible or explosive fluid, material, chemical or substance including, without
limitation, any hazardous substances as defined under Massachusetts General Laws chapter 21E, the Federal Comprehensive Environmental
Response Compensation and Liability Act (CERCLA), 42 USC §9601 et seq., as amended, under
Section 3001 of the Federal Resource Conservation and Recovery Act of 1976, as amended, or under any regulation of any governmental
authority regulating environmental or health matters (except for standard office supplies stored in proper containers), (ii) any
materials, appliances or equipment (including, without limitation, materials, appliances and equipment selected by Tenant for
the construction or other preparation of the Premises and furniture and carpeting) which pose any danger to life, safety or health
or may cause damage, injury or death; (iii) any unique, unusually valuable, rare or exotic property', work of art or the like
unless the same is fully insured under all-risk coverage, or (iv) any data processing, electronic, optical or other equipment
or property of a delicate, fragile or vulnerable nature unless the same are housed, shielded and protected against harm and damage,
whether by cleaning or maintenance personnel, radiations or emanations from other equipment now or hereafter installed in the
Building, or otherwise. Nor shall Tenant cause or permit any potentially harmful air emissions, odors of cooking or other processes,
or any unusual or other objectionable odors or emissions to emanate from or permeate the Premises.

 

17.7         Requirements
of Law-Fines and Penalties. Tenant at its sole expense shall comply with all laws, rules, orders and regulations, including,
without limitation, all energy-related requirements, of Federal, State, County and Municipal Authorities and with any direction
of any public officer or officers, pursuant to law, which shall impose any duty upon Landlord or Tenant with respect to or arising
out of Tenant’s use or occupancy of the Premises. Tenant shall reimburse and compensate Landlord for all expenditures made
by, or damages or fines sustained or incurred by, Landlord due to nonperformance or noncompliance with or breach or failure to
observe any item, covenant, or condition of this Lease upon Tenant’s part to be kept, observed, performed or complied with.
If Tenant receives notice of any violation of law, ordinance, order or regulation applicable to the Premises, it shall give prompt
notice thereof to Landlord.

 

    	-25-

    	 

    

 

17.8         Tenant’s
Acts—Effect on Insurance. Tenant shall not do or permit to be done any act or thing upon the Premises or elsewhere in
the Building which will invalidate or be in conflict with any insurance policies covering the Building and the fixtures and property
therein; and shall not do, or permit to be done, any act or thing upon the Premises which shall subject Landlord to any liability
or responsibility for injury to any person or persons or to property by reason of any business or operation being carried on upon
said Premises or for any other reason. Tenant at its own expense shall comply with all rules, orders, regulations and requirements
of the Board of Fire Underwriters, or any other similar body having jurisdiction, and shall not (i) do, or permit anything to be
done, in or upon the Premises, or bring or keep anything therein, except as now or hereafter permitted by the Fire Department,
Board of Underwriters, Fire Insurance Rating Organization, or other authority having jurisdiction, and then only in such quantity
and manner of storage as will not increase the rate for any insurance applicable to the Building, or (ii) use the Premises in a
manner which shall increase such insurance rates on the Building, or on property located therein, over that applicable when Tenant
first took occupancy of the Premises hereunder. If by reason of the failure of Tenant to comply with the provisions hereof the
insurance rate applicable to any policy of insurance shall at any time thereafter be higher than it otherwise would be, the Tenant
shall reimburse Landlord for that part of any insurance premiums thereafter paid by Landlord, which shall have been charged because
of such failure by Tenant.

 

17.9         Miscellaneous.
Tenant shall not suffer or permit the Premises or any fixtures, equipment or utilities therein or serving the same, to be overloaded,
damaged or defaced, nor permit any hole to be drilled or made in any part thereof. Tenant shall not suffer or permit any employee,
contractor, business invitee or visitor to violate any covenant, agreement or obligations of the Tenant under this Lease.

 

18.         DAMAGE
BY FIRE, ETC.

 

(a)          If
the Premises or the Building are damaged in whole or in part by any fire or other casualty (a “casualty”), the Tenant
shall immediately give notice thereof to the Landlord. Unless this Lease is terminated as provided herein, the Landlord, at its
own expense (except for any insurance deductibles, which shall be deemed Operating Costs), and proceeding with due diligence and
all reasonable dispatch, but subject to delays beyond the reasonable control of Landlord, shall repair and reconstruct the same
so as to restore the Premises (but not any alterations or additions made by or for Tenant or any trade fixtures, equipment or personal
property of Tenant) to substantially the same condition they were in prior to the casualty, subject to zoning, building and other
laws then in effect. Notwithstanding the foregoing, in no event shall Landlord be obligated either to repair or rebuild if the
damage or destruction results from an uninsured casualty or if the costs of such repairing or rebuilding exceeds the amount of
the insurance proceeds (net of all costs and expenses incurred in obtaining same) received by Landlord on account thereof. Landlord
shall not be liable for any inconvenience or annoyance to Tenant or injury to the business of Tenant resulting from delays in repairing
such damage.

 

(b)          Landlord
shall, within forty-five (45) days after the occurrence of a casualty, provide Tenant with a good faith estimate of the time required
to repair the damage to the Premises or the Building, as provided herein; if such estimate is for a period of more than one hundred
eighty (180) days from the occurrence of the casualty (or during the last eighteen (18) months of the term, for a period of more
than ninety (90) days), the Premises shall be deemed “substantially damaged”. If the Premises or the Building are substantially
damaged, Landlord may elect to terminate this Lease by giving Tenant written notice of such termination within sixty (60) days
of the date of such casualty; and if the Premises or the Building are substantially damaged, and if as a result the Premises are
rendered untenantable or inaccessible for the uses permitted under this Lease, then Tenant may terminate this Lease by giving Landlord
written notice of such termination within sixty (60) days of the date of such casualty.

 

(c)          For
so long as such damage results in material interference with the operation of Tenant’s use of the Premises which material
interference causes Tenant to be unable to use the Premises, the Yearly Rent payable by Tenant shall abate or be reduced proportionately
for the period, commencing on the day following such material interference and continuing until the Premises has been substantially
restored. Notwithstanding the foregoing, if such casualty was due to the fault or neglect of Tenant or Tenant’s employees,
contractors, invitees or agents, such abatement or reduction shall be made only if and to the extent of any proceeds of rental
interruption insurance actually received by Landlord and allocated to the Premises.

 

    	-26-

    	 

    

 

(d)          If
the Premises are damaged by a casualty, and the Lease is not terminated as provided herein, the Tenant, at its own expense, and
proceeding with all reasonable dispatch, shall repair and reconstruct all of the improvements, alterations and additions made to
the Premises by or for Tenant, including and any trade fixtures, equipment or personal property of Tenant which shall have been
damaged or destroyed.

 

Any dispute between the parties relating to
the provisions or obligations in this Article 18 shall be submitted to arbitration pursuant to Article 29.5 hereof.

 

19.         WAIVER
OF SUBROGATION

 

In any case in which Tenant shall be obligated
to pay to Landlord any loss, cost, damage, liability, or expense suffered or incurred by Landlord, Landlord shall allow to Tenant
as an offset against the amount thereof (i) the net proceeds of any insurance collected by Landlord for or on account of such loss,
cost, damage, liability or expense, provided that the allowance of such offset does not invalidate or prejudice the policy or policies
under which such proceeds were payable, and (ii) if such loss, cost, damage, liability or expense shall have been caused by a peril
against which Landlord has agreed to procure insurance coverage under the terms of this Lease, the amount of such insurance coverage,
whether or not actually procured by Landlord.

 

In any case in which Landlord or Landlord’s
managing agent shall be obligated to pay to Tenant any loss, cost, damage, liability or expense suffered or incurred by Tenant,
Tenant shall allow to Landlord or Landlord’s managing agent, as the case may be, as an offset against the amount thereof
(i) the net proceeds of any insurance collected by Tenant for or on account of such loss, cost, damage, liability, or expense,
provided that the allowance of such offset does not invalidate the policy or policies under which such proceeds were payable and
(ii) the amount of any loss, cost, damage, liability or expense caused by a peril against which Tenant is obligated to procure
insurance coverage under the terms of this Lease, the amount of such insurance coverage, whether or not actually procured by Tenant.

 

The parties hereto shall each procure an appropriate
clause in, or endorsement on, any property insurance policy covering the Premises and the Building and personal property, fixtures
and equipment located thereon and therein, pursuant to which the insurance companies waive subrogation or consent to a waiver of
right of recovery in favor of either party, its respective agents or employees. Having obtained such clauses and/or endorsements,
each party hereby agrees that it will not make any claim against or seek to recover from the other or its agents or employees for
any loss or damage to its property or the property of others resulting from fire or other perils covered by such property insurance.

 

20.         CONDEMNATION-EMINENT
DOMAIN

 

(a)          In
the event of any condemnation or taking in any manner for public or quasi-public use, which shall be deemed to include a voluntary
conveyance in lieu of a taking (a “taking”) of the whole of the Building, this Lease shall forthwith terminate as of
the date when Tenant is required to vacate the Premises.

 

(b)          Unless
this Lease is terminated as provided herein, the Landlord, at its own expense, and proceeding with due diligence and all reasonable
dispatch, but subject to delays beyond the reasonable control of Landlord, shall restore the remaining portion of the Premises
(but not any alterations or improvements made by or for Tenant or any trade fixtures, equipment or personal property of Tenant)
and the necessary portions of the Building as nearly as practicable to the same condition as it was prior to such taking, subject
to zoning and building laws then in effect. Notwithstanding the foregoing, Landlord’s obligation to restore the remaining
portion of the Premises shall be limited to the extent of the condemnation proceeds (net of all costs and expenses incurred in
connection with same) received by Landlord on account thereof. Landlord shall not be liable for any inconvenience or annoyance
to Tenant or injury to the business of Tenant resulting from delays in restoring the Premises.

 

    	-27-

    	 

    

 

(c)          In
the event that only a part of the Premises or the Building shall be taken, then, if such taking is a substantial taking (as hereinafter
defined), either Landlord or Tenant may by delivery of notice in writing to the other within sixty (60) days following the date
on which Landlord’s title has been divested by such authority, terminate this Lease, effective as of the date when Tenant
is required to vacate any portion of the Premises or appurtenant rights. A “substantial taking” shall mean a taking
which: requires restoration and repair of the remaining portion of the Building that cannot in the ordinary course be reasonably
expected to be repaired within one hundred eighty (180) days; results in the loss of reasonable access to the Premises; or results
in the loss of more than twenty-five percent (25%) of the rentable floor area of the Premises.

 

(d)          If
this Lease is not terminated as aforesaid, then this Lease shall continue in full force and effect, provided if as a result of
which there is material interference with the operation of Tenant’s use of the Premises, then the Yearly Rent and additional
rent payable by Tenant shall be justly and equitably abated and reduced according to the nature and extent of the loss of use thereof
suffered by Tenant.

 

(e)          Landlord
shall have and hereby reserves and excepts, and Tenant hereby grants and assigns to Landlord, all rights to recover for damages
to the Building, the Complex, and the leasehold interest hereby created (including any award made for the value of the estate vested
by this Lease in Tenant), and to compensation accrued or hereafter to accrue by reason of such taking, and by way of confirming
the foregoing, Tenant hereby grants and assigns, and covenants with Landlord to grant and assign, to Landlord all rights to such
damages of compensation. Nothing contained herein shall be construed to prevent Tenant from prosecuting in any condemnation proceedings
a separate claim for the value of any of Tenant’s personal property and for relocation expenses and business losses, provided
that such action shall not affect the amount of compensation otherwise recoverable by Landlord from the taking authority.

 

Any dispute between the parties relating to
the provisions or obligations in this Article 20 shall be submitted to arbitration pursuant to Article 29.5 hereof.

 

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21.         DEFAULT

 

21.1         Conditions
of Limitation-Re-Entry-Termination. This Lease and the herein term and estate are, upon the condition that if (a) subject to
Article 21.7, Tenant shall neglect or fail to perform or observe any of the Tenant’s covenants or agreements herein, including
(without limitation) the covenants or agreements with regard to the payment when due of rent, additional charges, reimbursement
for increase in Landlord’s costs, or any other charge payable by Tenant to Landlord (all of which shall be considered as
part of Yearly Rent for the purposes of invoking Landlord’s statutory or other rights and remedies in respect of payment
defaults); or (b) Tenant shall vacate, desert or abandon the Premises or the same shall become, or shall appear to have become,
vacant (whether or not the keys shall have been surrendered or the rent shall have been paid); or (c) Tenant shall be involved
in financial difficulties as evidenced by an admission in writing by Tenant of Tenant’s inability to pay its debts generally
as they become due, or by the making or offering to make a composition of its debts with its creditors; or (d) Tenant shall make
an assignment or trust mortgage, or other conveyance or transfer of like nature, of all or a substantial part of its property for
the benefit of its creditors, or (e) an attachment on mesne process, on execution or otherwise, or other legal process shall issue
against Tenant or its property and a sale of any of its assets shall be held thereunder; or (f) any judgment, final beyond appeal
or any lien, attachment or the like shall be entered, recorded or filed against Tenant in any court, registry, etc. and Tenant
shall fail to pay such judgment within thirty (30) days after the judgment shall have become final beyond appeal or to discharge
or secure by surety bond such lien, attachment, etc. within thirty (30) days of such entry, recording or filing, as the case may
be; or (g) the leasehold hereby created shall be taken on execution or by other process of law and shall not be revested in Tenant
within thirty (30) days thereafter; or (h) a receiver, sequesterer, trustee or similar officer shall be appointed by a court of
competent jurisdiction to take charge of all or any part of Tenant’s property and such appointment shall not be vacated within
thirty (30) days; or (i) any proceeding shall be instituted by or against Tenant pursuant to any of the provisions of any Act of
Congress or State law relating to bankruptcy, reorganizations, arrangements, compositions or other relief from creditors, and,
in the case of any proceeding instituted against it, if Tenant shall fail to have such proceedings dismissed within thirty (30)
days or if Tenant is adjudged bankrupt or insolvent as a result of any such proceeding, or (j) any event shall occur or any contingency
shall arise whereby this Lease, or the term and estate thereby created, would (by operation of law or otherwise) devolve upon or
pass to any person, firm or corporation other than Tenant, except as expressly permitted under Article 16 hereof - then, and in
any such event Landlord may, by notice to Tenant, elect to terminate this Lease; and thereupon (and without prejudice to any remedies
which might otherwise be available for arrears of rent or other charges due hereunder or preceding breach of covenant or agreement
and without prejudice to Tenant’s liability for damages as hereinafter stated), upon the giving of such notice, this Lease
shall terminate as of the date specified therein as though that were the Termination Date as stated in Section 3.2. Without being
taken or deemed to be guilty of any manner of trespass or conversion, and without being liable to indictment, prosecution or damages
therefor, Landlord may, forcibly if necessary, enter into and upon the Premises (or any part thereof in the name of the whole);
repossess the same as of its former estate; and expel Tenant and those claiming under Tenant. Wherever “Tenant “ is
used in subdivisions (c), (d), (e), (f), (g), (h) and (i) of this Article 25.1, it shall be deemed to include any one of (i) any
corporation of which Tenant is a controlled subsidiary and (ii) any guarantor of any of Tenant’s obligations under this Lease.
The words “re-entry” and “re-enter” as used in this Lease are not restricted to their technical legal meanings.

 

21.2         Intentionally
Omitted.

 

21.3         Damages-Termination.
Upon the termination of this Lease under the provisions of this Article 21, Tenant shall pay to Landlord the rent and other charges
payable by Tenant to Landlord up to the time of such termination, shall continue to be liable for any preceding breach of covenant,
and in addition, shall pay to Landlord as damages, at the election of Landlord

 

either:

 

(x)          the amount by which, at the time of the termination
of this Lease (or at any time thereafter if Landlord shall have initially elected damages under subparagraph (y), below), (i) the
aggregate of the rent and other charges projected over the period commencing with such termination and ending on the Termination
Date as stated in Exhibit 1 exceeds (ii) the aggregate projected fair market rental value of the Premises for such period;

 

or:

 

(y)          amounts equal to the rent and other charges
which would have been payable by Tenant had this Lease not been so terminated, payable upon the due dates therefor specified herein
following such termination and until the Termination Date as specified in Exhibit 1, provided, however, if Landlord shall re-let
the Premises during such period, that Landlord shall credit Tenant with the net rents received by Landlord from such re-letting,
such net rents to be determined by first deducting from the gross rents as and when received by Landlord from such re-letting the
expenses incurred or paid by Landlord in terminating this Lease, as well as the expenses of re-letting, including altering and
preparing the Premises for new tenants, brokers’ commissions, and all other similar and dissimilar expenses properly chargeable
against the Premises and the rental therefrom, it being understood that any such re-letting may be for a period equal to or shorter
or longer than the remaining term of this Lease; and provided, further, that (i) in no event shall Tenant be entitled to receive
any excess of such net rents over the sums payable by Tenant to Landlord hereunder and (it) in no event shall Tenant be entitled
in any suit for the collection of damages pursuant to this Subparagraph (y) to a credit in respect of any net rents from a re-letting
except to the extent that such net rents are actually received by Landlord prior to the commencement of such suit. If the Premises
or any part thereof should be re-let in combination with other space, then proper apportionment on a square foot area basis shall
be made of the rent received from such re-letting and of the expenses of re-letting.

 

    	-29-

    	 

    

 

In calculating the rent and other charges under
Subparagraph (x), above, there shall be included, in addition to the Yearly Rent, Tax Share and Operating Expense Share and all
other considerations agreed to be paid or performed by Tenant, on the assumption that all such amounts and considerations would
have remained constant (except as herein otherwise provided) for the balance of the full term hereby granted.

 

Suit or suits for the recovery of such damages,
or any installments thereof, may be brought by Landlord from time to time at its election, and nothing contained herein shall be
deemed to require Landlord to postpone suit until the date when the term of this Lease would have expired if it had not been terminated
hereunder.

 

Nothing herein contained shall be construed
as limiting or precluding the recovery by Landlord against Tenant of any sums or damages to which, in addition to the damages particularly
provided above, Landlord may lawfully be entitled by reason of any default hereunder on the part of Tenant. Notwithstanding anything
to the contrary, Landlord shall be entitled to recover, in addition to the rent and other charges under Subparagraph (x) or (y)
above, any other amount necessary to compensate Landlord for all detriment proximately caused by Tenant’s failure to perform
its obligations under the Lease or which in the ordinary course of things would be likely to result therefrom, including, but not
limited to, the cost of recovering possession of the Premises, reasonable attorneys’ fees, any real estate commissions actually
paid by Landlord and the unamortized value of any free rent, reduced rent, tenant improvement allowance or other economic concessions
provided by Landlord.

 

21.4         Fees
and Expenses.

 

(a)          If
Tenant shall default in the performance of any covenant on Tenant’s part to be performed as in this Lease contained, Landlord
may immediately, or at any time thereafter, without notice, perform the same for the account of Tenant. If Landlord at any time
is compelled to pay or elects to pay any sum of money, or do any act which will require the payment of any sum of money, by reason
of the failure of Tenant to comply with any provision hereof, or if Landlord is compelled to or does incur any expense, including
reasonable attorneys’ fees, in instituting, prosecuting, and/or defending any action or proceeding instituted by reason of
any default of Tenant hereunder, Tenant shall on demand pay to Landlord by way of reimbursement the sum or sums so paid by Landlord
with all costs and damages, plus interest computed as provided in Article 6 hereof.

 

(b)          Tenant
shall pay Landlord’s cost and expense, including reasonable attorneys’ fees, incurred (i) in enforcing any obligation
of Tenant under this Lease or (ii) as a result of Landlord, without its fault, being made party to any litigation pending by or
against Tenant or any persons claiming through or under Tenant.

 

21.5         Waiver
of Redemption. Tenant does hereby waive and surrender all rights and privileges which it might have under or by reason of any
present or future law to redeem the Premises or to have a continuance of this Lease for the term hereby demised after being dispossessed
or ejected therefrom by process of law or under the terms of this Lease or after the termination of this Lease as herein provided.

 

21.6         Landlord’s
Remedies Not Exclusive. The specified remedies to which Landlord may resort hereunder are cumulative and are not intended to
be exclusive of any remedies or means of redress to which Landlord may at any time be lawfully entitled, and Landlord may invoke
any remedy (including the remedy of specific performance) allowed at law or in equity as if specific remedies were not herein provided
for.

 

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21.7         Grace
Period. Notwithstanding anything to the contrary in this Article contained, Landlord agrees not to take any action to terminate
this Lease (a) for default by Tenant in the payment when due of any sum of money, if Tenant shall cure such default within five
(5) consecutive business days after written notice thereof is given by Landlord to Tenant, provided, however, that no such notice
need be given and no such default in the payment of money shall be curable if on two (2) prior occasions there had been a default
in the payment of money which had been cured after notice thereof had been given by Landlord to Tenant as herein provided or (b)
for default by Tenant in the performance of any covenant other than a covenant to pay a sum of money, if Tenant shall cure such
default within a period of thirty (30) days after written notice thereof given by Landlord to Tenant (the "Non-Monetary Grace
Period”) (except where the nature of the default is such that remedial action should appropriately take place sooner, as
indicated in such written notice), or within such additional period as may reasonably be required to cure such default if (because
of governmental restrictions or any other cause beyond the reasonable control of Tenant) the default is of such a nature that it
cannot be cured within such thirty (30) day period, provided, however, (1) that there shall be no extension of time beyond such
thirty (30) day period for the curing of any such default unless, not more than ten (10) days after the receipt of the notice of
default, Tenant in writing (i) shall specify the cause on account of which the default cannot be cured during such period and shall
advise Landlord of its intention duly to institute all steps necessary to cure the default and (ii) shall, as soon as reasonably
practicable, duly institute and thereafter diligently prosecute to completion all steps necessary to cure such default and, (2)
that no notice of the opportunity to cure a default need be given, and no grace period whatsoever shall be allowed to Tenant, if
the default is incurable or if the covenant or condition the breach of which gave rise to default had, by reason of a breach on
a prior occasion, been the subject of a notice hereunder to cure such default. Notwithstanding the foregoing, Tenant shall have
no right to notice or the Non-Monetary Grace Period relating to its failure to (v) maintain all insurance as required in Article
15 above; (w) deliver to Landlord the Security Deposit as required by Section 29.13 below; (x) provide Landlord with Estoppel Certificates
as required pursuant to Section 17.5 above; (y) provide Landlord with subordination agreements as required pursuant to Article
23 below; or (z) provide Landlord with the certificates of insurance required pursuant to Article 15 above.

 

Notwithstanding anything to the contrary in
this Article 21.7 contained, except to the extent prohibited by applicable law, any statutory notice and grace periods provided
to Tenant by law are hereby expressly waived by Tenant.

 

22.         END
OF TERM-ABANDONED PROPERTY

 

Upon the expiration or other termination of
the term of this Lease, Tenant shall peaceably quit and surrender to Landlord the Premises and all alterations and additions thereto,
broom clean, in good order, repair and condition (except as provided herein and in Articles 8.7, 18 and 20) excepting only ordinary
wear and use (as defined in Article 14.1 hereof) and damage by fire or other casualty for which, under other provisions of this
Lease, Tenant has no responsibility of repair or restoration. Tenant shall remove all of its property, including, without limitation,
all telecommunication, computer and other cabling installed by Tenant in the Premises or elsewhere in the Building (unless Landlord
agrees in writing, at its sole discretion, that same may be labeled and left in place), and, to the extent specified by Landlord
as provided hereinabove, all alterations and additions made by Tenant and all partitions made by Tenant wholly within the Premises,
and shall repair any damages to the Premises or the Building caused by their installation or by such removal. Tenant’s obligation
to observe or perform this covenant shall survive the expiration or other termination of the term of this Lease.

 

Tenant will remove any personal property from
the Building and the Premises upon or prior to the expiration or termination of this Lease and any such property which shall remain
in the Building or the Premises thereafter shall be conclusively deemed to have been abandoned, and may either be retained by Landlord
as its property or sold or otherwise disposed of in such manner as Landlord may see fit. If any part thereof shall be sold, Landlord
may receive and retain the proceeds of such sale and apply the same, at its option, against the expenses of the sale, the cost
of moving and storage, any arrears of Yearly Rent, additional or other charges payable hereunder by Tenant to Landlord and any
damages to which Landlord may be entitled under Article 21 hereof or pursuant to law.

 

    	-31-

    	 

    

 

If Tenant or anyone claiming under Tenant shall
remain in possession of the Premises or any part thereof after the expiration or prior termination of the term of this Lease without
any agreement in writing between Landlord and Tenant with respect thereto, then, prior to the acceptance of any payments for rent
or use and occupancy by Landlord, the person remaining in possession shall be deemed a tenant-at-sufferance. Whereas the parties
hereby acknowledge that Landlord may need the Premises after the expiration or prior termination of the term of the Lease for other
tenants and that the damages which Landlord may suffer as the result of Tenant’s holding-over cannot be determined as of
the Execution Date hereof, in the event that Tenant so holds over, Tenant shall pay to Landlord in addition to all rental and other
charges due and accrued under the Lease prior to the date of termination, charges (based upon fair market rental value of the Premises)
for use and occupation of the Premises thereafter and, in addition to such sums and any and all other rights and remedies which
Landlord may have at law or in equity, an additional use and occupancy charge in the amount of fifty percent (50%) of either the
Yearly Rent and other charges calculated (on a daily basis) at the highest rate payable under the terms of this Lease, but measured
from the day on which Tenant’s hold-over commenced and terminating on the day on which Tenant vacates the Premises or the
fair market value of the Premises for such period, whichever is greater. In addition, Tenant shall save Landlord, its agents and
employees, harmless and will exonerate, defend and indemnify Landlord, its agents and employees, from and against any and all damages
which Landlord may suffer on account of Tenant’s holdover in the Premises after the expiration or prior termination of the
term of the Lease.

 

23.         SUBORDINATION

 

(a)          Subject
to any mortgagee’s or ground lessor’s election, as hereinafter provided for, this Lease is subject and subordinate
in all respects to all matters of record (including, without limitation, deeds and land disposition agreements), ground leases
and/or underlying leases, and all mortgages, any of which may now or hereafter be placed on or affect such leases and/or the real
property of which the Premises are a part, or any part of such real property, and/or Landlord’s interest or estate therein,
and to each advance made and/or hereafter to be made under any such mortgages, and to all renewals, modifications, consolidations,
replacements and extensions thereof and all substitutions therefor. This Article 23 shall be self-operative and no further instrument
or subordination shall be required. In confirmation of such subordination, Tenant shall execute, acknowledge and deliver promptly
any certificate or instrument that Landlord and/or any mortgagee and/or lessor under any ground or underlying lease and/or their
respective successors in interest may request, subject to Landlord’s, mortgagee’s and ground lessor’s right to
do so for, on behalf and in the name of Tenant under certain circumstances, as hereinafter provided. Tenant acknowledges that,
where applicable, any consent or approval hereafter given by Landlord may be subject to the further consent or approval of such
mortgagee and/or ground lessor; and the failure or refusal of such mortgagee and/or ground lessor to give such consent or approval
shall, notwithstanding anything to the contrary in this Lease contained, constitute reasonable justification for Landlord’s
withholding its consent or approval.

 

(b)          Any
such mortgagee or ground lessor may from time to time subordinate or revoke any such subordination of the mortgage or ground lease
held by it to this Lease. Such subordination or revocation, as the case may be, shall be effected by written notice to Tenant and
by recording an instrument of subordination or of such revocation, as the case may be, with the appropriate registry of deeds or
land records and to be effective without any further act or deed on the part of Tenant. In confirmation of such subordination or
of such revocation, as the case may be, Tenant shall execute, acknowledge and promptly deliver any certificate or instrument that
Landlord, any mortgagee or ground lessor may request, subject to Landlord’s, mortgagee’s and ground lessor’s
right to do so for, on behalf and in the name of Tenant under certain circumstances, as hereinafter provided.

 

(c)          Without
limitation of any of the provisions of this Lease, if any ground lessor or mortgagee shall succeed to the interest of Landlord
by reason of the exercise of its rights under such ground lease or mortgage (or the acceptance of voluntary conveyance in lieu
thereof) or any third party (including, without limitation, any foreclosure purchaser or mortgage receiver) shall succeed to such
interest by reason of any such exercise or the expiration or sooner termination of such ground lease, however caused, then such
successor may, upon notice and request to Tenant (which, in the case of a ground lease, shall be within thirty (30) days after
such expiration or sooner termination), succeed to the interest of Landlord under this Lease, provided, however, that such successor
shall not: (i) be liable for any previous act or omission of Landlord under this Lease; (ii) be subject to any offset, defense,
or counterclaim which shall theretofore have accrued to Tenant against Landlord; (iii) have any obligation with respect to any
security deposit unless it shall have been paid over or physically delivered to such successor; or (iv) be bound by any previous
modification of this Lease or by any previous payment of Yearly Rent for a period greater than one (1) month, made without such
ground lessor’s or mortgagee’s consent where such consent is required by applicable ground lease or mortgage documents.
In the event of such succession to the interest of the Landlord — and notwithstanding that any such mortgage or ground lease
may antedate this Lease — the Tenant shall attorn to such successor and shall ipso facto be and become bound directly to
such successor in interest to Landlord to perform and observe all the Tenant’s obligations under this Lease without the necessity
of the execution of any further instrument. Nevertheless, Tenant agrees at any time and from time to time during the term hereof
to execute a suitable instrument in confirmation of Tenant’s agreement to attorn, as aforesaid, subject to Landlord’s,
mortgagee’s and ground lessor’s right to do so for, on behalf and in the name of Tenant under certain circumstances,
as hereinafter provided.

 

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(d)          The
term “mortgage(s)” as used in this Lease shall include any mortgage or deed of trust. The term “mortgagee(s)”
as used in this Lease shall include any mortgagee or any trustee and beneficiary under a deed of trust or receiver appointed under
a mortgage or deed of trust. The term “mortgagor(s)” as used in this Lease shall include any mortgagor or any grantor
under a deed of trust.

 

(e)          Tenant
hereby irrevocably constitutes and appoints Landlord or any such mortgagee or ground lessor, and their respective successors in
interest, acting singly, Tenant’s attorney-in-fact to execute and deliver any such certificate or instrument for, on behalf
and in the name of Tenant, but only if Tenant fails to execute, acknowledge and deliver any such certificate or instrument within
ten (10) days after Landlord or such mortgagee or such ground lessor has made written request therefor.

 

(f)          Notwithstanding
anything to the contrary contained in this Article 23, if all or part of Landlord’s estate and interest in the real property
of which the Premises are a part shall be a leasehold estate held under a ground lease, then: (i) the foregoing subordination provisions
of this Article 23 shall not apply to any mortgages of the fee interest in said real property to which Landlord’s leasehold
estate is not otherwise subject and subordinate; and (ii) the provisions of this Article 23 shall in no way waive, abrogate or
otherwise affect any agreement by any ground lessor (x) not to terminate this Lease incident to any termination of such ground
lease prior to its term expiring or (y) not to name or join Tenant in any action or proceeding by such ground lessor to recover
possession of such real property or for any other relief.

 

(g)          In
the event of any failure by Landlord to perform, fulfill or observe any agreement by Landlord herein, in no event will the Landlord
be deemed to be in default under this Lease permitting Tenant to exercise any or all rights or remedies under this Lease until
the Tenant shall have given written notice of such failure to any mortgagee (ground lessor and/or trustee) of which Tenant shall
have been advised and until a reasonable period of time shall have elapsed following the giving of such notice, during which such
mortgagee (ground lessor and/or trustee) shall have the right, but shall not be obligated, to remedy such failure.

 

24.         QUIET
ENJOYMENT

 

Landlord covenants that if, and so long as,
Tenant keeps and performs each and every covenant, agreement, term, provision and condition herein contained on the part and on
behalf of Tenant to be kept and performed, Tenant shall quietly enjoy the Premises from and against the claims of all persons claiming
by, through or under Landlord subject, nevertheless, to the covenants, agreements, terms, provisions and conditions of this Lease
and to the mortgages, ground leases and/or underlying leases to which this Lease is subject and subordinate, as hereinabove set
forth.

 

Without incurring any liability to Tenant, Landlord
may permit access to the Premises and open the same, whether or not Tenant shall be present, upon any demand of any receiver, trustee,
assignee for the benefit of creditors, sheriff, marshal or court officer entitled to, or reasonably purporting to be entitled to,
such access for the purpose of taking possession of, or removing, Tenant’s property or for any other lawful purpose (but
this provision and any action by Landlord hereunder shall not be deemed a recognition by Landlord that the person or official making
such demand has any right or interest in or to this Lease, or in or to the Premises), or upon demand of any representative of the
fire, police, building, sanitation or other department of the city, state or federal governments.

 

    	-33-

    	 

    

 

25.         ENTIRE
AGREEMENT-WAIVER-SURRENDER

 

25.1         Entire
Agreement. This Lease and the Exhibits made a part hereof contain the entire and only agreement between the parties and any
and all statements and representations, written and oral, including previous correspondence and agreements between the parties
hereto, are merged herein. Tenant acknowledges that all representations and statements upon which it relied in executing this Lease
are contained herein and that the Tenant in no way relied upon any other statements or representations, written or oral. Any executory
agreement hereafter made shall be ineffective to change, modify, discharge or effect an abandonment of this Lease in whole or in
part unless such executory agreement is in writing and signed by the party against whom enforcement of the change, modification,
discharge or abandonment is sought.

 

25.2         Waiver
by Landlord. The failure of Landlord to seek redress for violation, or to insist upon the strict performance, of any covenant
or condition of this Lease, or any of the Rules and Regulations promulgated hereunder, shall not prevent a subsequent act, which
would have originally constituted a violation, from having all the force and effect of an original violation. The receipt by Landlord
of rent with knowledge of the breach of any covenant of this Lease shall not be deemed a waiver of such breach. The failure of
Landlord to enforce any of such Rules and Regulations against Tenant and/or any other tenant in the Building shall not be deemed
a waiver of any such Rules and Regulations. No provisions of this Lease shall be deemed to have been waived by Landlord unless
such waiver be in writing signed by Landlord. No payment by Tenant or receipt by Landlord of a lesser amount than the monthly rent
herein stipulated shall be deemed to be other than on account of the stipulated rent, nor shall any endorsement or statement on
any check or any letter accompanying any check or payment as rent be deemed an accord and satisfaction, and Landlord may accept
such check or payment without prejudice to Landlord’s right to recover the balance of such rent or pursue any other remedy
in this Lease provided.

 

25.3         Surrender.
No act or thing done by Landlord during the term hereby demised shall be deemed an acceptance of a surrender of the Premises, and
no agreement to accept such surrender shall be valid, unless in writing signed by Landlord. No employee of Landlord or of Landlord’s
agents shall have any power to accept the keys of the Premises prior to the termination of this Lease. The delivery of keys to
any employee of Landlord or of Landlord’s agents shall not operate as a termination of the Lease or a surrender of the Premises.
In the event that Tenant at any time desires to have Landlord underlet the Premises for Tenant’s account, Landlord or Landlord’s
agents are authorized to receive the keys for such purposes without releasing Tenant from any of the obligations under this Lease,
and Tenant hereby relieves Landlord of any liability for loss of or damage to any of Tenant’s effects in connection with
such underletting.

 

26.         INABILITY
TO PERFORM-EXCULPATORY CLAUSE

 

(a)          Except
as provided in Articles 4.1 and 4.2 hereof, this Lease and the obligations of Tenant to pay rent hereunder and perform all the
other covenants, agreements, terms, provisions and conditions hereunder on the part of Tenant to be performed shall in no way be
affected, impaired or excused because Landlord is unable to fulfill any of its obligations under this Lease or is unable to supply
or is delayed in supplying any service expressly or impliedly to be supplied or is unable to make or is delayed in making any repairs,
replacements, additions, alterations, improvements or decorations or is unable to supply or is delayed in supplying any equipment
or fixtures if Landlord is prevented or delayed from so doing by reason of strikes or labor troubles or any other similar or dissimilar
cause whatsoever beyond Landlord’s reasonable control, including but not limited to, governmental preemption in connection
with a national emergency or by reason of any rule, order or regulation of any department or subdivision thereof of any governmental
agency or by reason of the conditions of supply and demand which have been or are affected by war, hostilities or other similar
or dissimilar emergency. In each such instance of inability of Landlord to perform, Landlord shall exercise reasonable diligence
to eliminate the cause of such inability to perform.

 

    	-34-

    	 

    

 

(b)          Tenant
shall neither assert nor seek to enforce any claim against Landlord, or Landlord’s agents or employees, or the assets of
Landlord or of Landlord’s agents or employees, for breach of this Lease or otherwise, other than against Landlord’s
interest in the Building of which the Premises are a part and in the uncollected rents, issues and profits thereof, and Tenant
agrees to look solely to such interest for the satisfaction of any liability of Landlord under this Lease, it being specifically
agreed that in no event shall Landlord or Landlord’s agents or employees (or any of the officers, trustees, directors, partners,
beneficiaries, joint venturers, members, stockholders or other principals or representatives, and the like, disclosed or undisclosed,
thereof) ever be personally liable for any such liability. This paragraph shall not limit any right that Tenant might otherwise
have to obtain injunctive relief against Landlord or to take any other action which shall not involve the personal liability of
Landlord to respond in monetary damages from Landlord’s assets other than the Landlord’s interest in said real estate,
as aforesaid. In no event shall Landlord or Landlord’s agents or employees (or any of the officers, trustees, directors,
partners, beneficiaries, joint venturers, members, stockholders or other principals or representatives and the like, disclosed
or undisclosed, thereof) ever be liable for consequential or incidental damages. Without limiting the foregoing, in no event shall
Landlord or Landlord’s agents or employees (or any of the officers, trustees, directors, partners, beneficiaries, joint venturers,
members, stockholders or other principals or representatives and the like, disclosed or undisclosed, thereof) ever be liable for
lost profits of Tenant.

 

(c)          Landlord
shall not be deemed to be in default of its obligations under the Lease unless Tenant has given Landlord written notice of such
default, and Landlord has failed to cure such default within thirty (30) days after Landlord receives such notice or such longer
period of time as Landlord may reasonably require to cure such default. Except as otherwise expressly provided in this Lease, in
no event shall Tenant have the right to terminate the Lease nor shall Tenant's obligation to pay Yearly Rent or other charges under
this Lease abate based upon any default by Landlord of its obligations under the Lease.

 

27.         BILLS
AND NOTICES

 

Any notice, consent, request, bill, demand or
statement hereunder by either party to the other party shall be in writing and, if received at Landlord’s or Tenant’s
address, shall be deemed to have been duly given when either delivered or served personally or sent via overnight mail (via nationally
recognized courier) or mailed by first class mail postage paid certified or registered mail return receipt requested, addressed
to Landlord at its address as stated in Exhibit 1 with a copy to Landlord, c/o Beal and Company, Inc., One Kendall Square, Building
400, 2nd Floor, Cambridge, Massachusetts 02139; ATTN: General Manager and a copy to Sherin and Lodgen LLP, 101 Federal Street,
Boston, Massachusetts 02110, ATTN: Robert M. Carney, and to Tenant at the Premises (or at Tenant’s address as stated in Exhibit
1, if mailed prior to Tenant’s occupancy of the Premises), and a copy to Edwards Wildman Palmer LLP, 111 Huntington Avenue,
Boston, Massachusetts 02199, ATTN: Jonathan Lourie, or if any address for notices shall have been duly changed as hereinafter provided,
if mailed as aforesaid to the part)' at such changed address. Either party may at any time change the address or specify an additional
address for such notices, consents, requests, bills, demands or statements by delivering or mailing, as aforesaid, to the other
party a notice stating the change and setting forth the changed or additional address, provided such changed or additional address
is within the United States.

 

If Tenant is a partnership, Tenant, for itself,
and on behalf of all of its partners, hereby appoints Tenant’s Service Partner, as identified on Exhibit i, to accept service
of any notice, consent, request, bill, demand or statement hereunder by Landlord and any service of process in any judicial proceeding
with respect to this Lease on behalf of Tenant and as agent and attorney-in-fact for each partner of Tenant.

 

All bills and statements for reimbursement or
other payments or charges due from Tenant to Landlord hereunder shall be due and payable in full thirty (30) days, unless herein
otherwise provided, after submission thereof by Landlord to Tenant. Tenant’s failure to make timely payment of any amounts
indicated by such bills and statements, whether for work done by Landlord at Tenant’s request, reimbursement provided for
by this Lease or for any other sums properly owing by Tenant to Landlord, shall be treated as a default in the payment of rent,
in which event Landlord shall have all rights and remedies provided in this Lease for the nonpayment of rent.

 

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28.         PARTIES
BOUND-SEIZING OF TITLE

 

The covenants, agreements, terms, provisions
and conditions of this Lease shall bind and benefit the successors and assigns of the parties hereto with the same effect as if
mentioned in each instance where a party hereto is named or referred to, except that no violation of the provisions of Article
16 hereof shall operate to vest any rights in any successor or assignee of Tenant and that the provisions of this Article 28 shall
not be construed as modifying the conditions of limitation contained in Article 21 hereof.

 

If, in connection with or as a consequence of
the sale, transfer or other disposition of the real estate (land and/or Building, either or both, as the case may be) of which
the Premises are a part, Landlord ceases to be the owner of the reversionary interest in the Premises, Landlord shall be entirely
freed and relieved from the performance and observance thereafter of all covenants and obligations hereunder on the part of Landlord
to be performed and observed, it being understood and agreed in such event (and it shall be deemed and construed as a covenant
running with the land) that the person succeeding to Landlord’s ownership of said reversionary interest shall thereupon and
thereafter assume, and perform and observe, any and all of such covenants and obligations of Landlord.

 

29.         MISCELLANEOUS

 

29.1         Separability.
If any provision of this Lease or portion of such provision or the application thereof to any person or circumstance is for any
reason held invalid or unenforceable, the remainder of the Lease (or the remainder of such provision) and the application thereof
to other persons or circumstances shall not be affected thereby.

 

29.2         Captions,
etc. The captions are inserted only as a matter of convenience and for reference, and in no way define, limit or describe the
scope of this Lease nor the intent of any provisions thereof. References to “State” shall mean, where appropriate,
the Commonwealth of Massachusetts.

 

29.3         Broker.
Landlord and Tenant each represents and warrants to the other that it has not directly or indirectly dealt, with respect to the
leasing of space between one and other in the Building or the Land of which it is a part (called “Building, etc.” in
this Article 29.3) with any broker or had its attention called to the Premises or other space to let in the Building, etc., by
anyone other than the broker, person or firm, if any, designated in Exhibit 1. Tenant agrees to defend, exonerate and save harmless
and indemnify Landlord and anyone claiming by, through or under Landlord against any claims for a commission arising out of the
execution and delivery of this Lease or out of negotiations between Landlord and Tenant with respect to the leasing of other space
in the Building, etc., provided that Landlord shall be solely responsible for the payment of brokerage commissions to the broker,
person or firm, if any, designated in Exhibit 1, in accordance with a separate agreement. Landlord agrees to defend, exonerate
and save harmless and indemnify Tenant and anyone claiming by, through or under Tenant against any claims for a commission arising
out of the execution and delivery of this Lease or out of negotiations between Landlord and Tenant with respect to the leasing
of other space in the Building.

 

29.4         Modifications.
If in connection with obtaining financing for the Building, a bank, insurance company, pension trust or other institutional lender
shall request reasonable modifications in this Lease as a condition to such financing, Tenant will not withhold, delay or condition
its consent thereto, provided that such modifications do not increase the obligations of Tenant hereunder or materially adversely
affect the leasehold interest hereby created.

 

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29.5         Arbitration.
Any disputes relating to the provisions or obligations contained in Articles 2.1, 18 and 20 of this Lease as to which a specific
provision for a reference to arbitration is made herein shall be submitted to arbitration in accordance with the provisions of
applicable state law (as identified on Exhibit 1), as from time to time amended. Arbitration proceedings, including the selection
of an arbitrator, shall be conducted pursuant to the rules, regulations and procedures from time to time in effect as promulgated
by the American Arbitration Association. Prior written notice of application by either party for arbitration shall be given to
the other at least ten (10) days before submission of the application to the said Association’s office in the City wherein
the Building is situated (or the nearest other city having an Association office), The arbitrator shall hear the parties and their
evidence. The decision of the arbitrator shall be binding and conclusive, and judgment upon the award or decision of the arbitrator
may be entered in the appropriate court of law (as identified on Exhibit 1); and the parties consent to the jurisdiction of such
court and further agree that any process or notice of motion or other application to the Court or a Judge thereof may be served
outside the State wherein the Building is situated by registered mail or by personal service, provided a reasonable time for appearance
is allowed. The costs and expenses of each arbitration hereunder and their apportionment between the parties shall be determined
by the arbitrator in his award or decision. No arbitrable dispute shall be deemed to have arisen under this Lease prior to the
expiration of the period of twenty (20) days after the date of the giving of written notice by the party asserting the existence
of the dispute together with a description thereof sufficient for an understanding thereof.

 

29.6         Governing
Law. This Lease is made pursuant to, and shall be governed by, and construed in accordance with, the laws of the State wherein
the Building is situated and any applicable local municipal rules, regulations, by-laws, ordinances and the like.

 

29.7         Assignment
of Rents. With reference to any assignment by Landlord of its interest in this Lease, or the rents payable hereunder, conditional
in nature or otherwise, which assignment is made to or held by a bank, trust company, insurance company or other institutional
lender holding a mortgage or ground lease on the Building, Tenant agrees:

 

(a)          that
the execution thereof by Landlord and the acceptance thereof by such mortgagee and/or ground lessor shall never be deemed an assumption
by such mortgagee and/or ground lessor of any of the obligations of the Landlord hereunder, unless such mortgagee and/or ground
lessor shall, by written notice sent to the Tenant, specifically otherwise elect; and

 

(b)          that,
except as aforesaid, such mortgagee and/or ground lessor shall be treated as having assumed the Landlord’s obligations hereunder
only upon foreclosure of such mortgagee’s mortgage or deed of trust or termination of such ground lessor’s ground lease
and the taking of possession of the demised Premises after having given notice of its exercise of the option stated in Article
23 hereof to succeed to the interest of the Landlord under this Lease.

 

29.8         Representation
of Authority. By his or her execution hereof each of the signatories on behalf of the respective parties hereby warrants and
represents to the other that he is duly authorized to execute this Lease on behalf of such party. If Tenant is a corporation, Tenant
hereby appoints the signatory whose name appears below on behalf of Tenant as Tenant’s attorney-in-fact for the purpose of
executing this Lease for and on behalf of Tenant.

 

29.9         Expenses
Incurred by Landlord Upon Tenant Requests. Tenant shall, upon demand, reimburse Landlord for all reasonable expenses, including,
without limitation, reasonable legal fees, incurred by Landlord in connection with all requests by Tenant for consents, approvals
or execution of collateral documentation related to this Lease, including, without limitation, costs incurred by Landlord in the
review and approval of Tenant’s plans and specifications in connection with proposed alterations to be made by Tenant to
the Premises, requests by Tenant to sublet the Premises or assign its interest in the Lease, the execution by Landlord of estoppel
certificates requested by Tenant, and requests by Tenant for Landlord to execute waivers of Landlord’s interest in Tenant’s
property in connection with third party financing by Tenant. Such costs shall be deemed to be additional rent under the Lease.

 

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29.10         Survival.
Without limiting any other obligation of the Tenant which may survive the expiration or prior termination of the term of the Lease,
all obligations on the part of Tenant to indemnify, defend, or hold Landlord harmless, as set forth in this Lease (including, without
limitation, Tenant’s obligations under Articles 13(d), 15.3, and 29.3) shall survive the expiration or prior termination
of the term of the Lease.

 

29.11         Hazardous
Materials. Landlord and Tenant agree as follows with respect to the existence or use of "Hazardous Material" in or
on the Premises, the Building or the Complex.

 

(a)          Tenant,
at its sole cost and expense, shall comply with the Emergency Planning and Community Right to Know Act (EPCRTKA) 42 U.S.C. §
11001-11050, and all other laws, statutes, ordinances, rules and regulations of any local, state or federal governmental authority
having jurisdiction concerning environmental, health and safety matters (collectively, "Environmental Laws"), including,
but not limited to, any discharge into the air, surface, water, sewers, soil or groundwater of any Hazardous Material (as defined
in Article 29.11(c)), whether within or outside the Premises within the Complex. Tenant shall comply with all terms, conditions
and guidelines contained in the MWRA permit applicable to the Premises (which Tenant shall be obligated to obtain) and agrees to
further acknowledge such agreement to so comply in writing upon request of Landlord. Notwithstanding the foregoing, nothing contained
in this Lease requires, or shall be construed to require, Tenant to incur any liability related to or arising from environmental
conditions (i) for which the Landlord is responsible pursuant to the terms of this Lease, or (ii) which existed within the Premises
or the Complex prior to the date Tenant takes possession of the Premises.

 

(b)          Tenant
shall not cause or permit any Hazardous Material to be brought upon, kept or used in or about the Premises or otherwise in the
Complex by Tenant, its agents, employees, contractors or invitees, without the prior written consent of Landlord, except for Hazardous
Materials which are typically used in the operation of offices or laboratories, provided that such materials are stored, used and
disposed of in strict compliance with all applicable Environmental Laws and with good scientific and medical practice. Within five
(5) days of Landlord’s request, Tenant shall provide Landlord with a list of all Hazardous Materials, including quantities
used and such other information as Landlord may reasonably request, used by Tenant in the Premises or otherwise in the Complex.
Notwithstanding the foregoing, with respect to any of Tenant's Hazardous Material which Tenant does not properly handle, store
or dispose of in compliance with all applicable Environmental Laws and good scientific and medical practice, Tenant shall, upon
written notice from Landlord, no longer have the right to bring such material into the Premises, Building of which the Premises
is a part or the Complex until Tenant has demonstrated, to Landlord's reasonable satisfaction, that Tenant has implemented programs
to thereafter properly handle, store or dispose of such material.

 

(c)          As
used herein, the term "Hazardous Material" means any hazardous or toxic substance, material or waste or petroleum derivative
which is or becomes regulated by any Environmental Law, specifically including live organisms, viruses and fungi, medical waste,
and so-called “biohazard” materials. The term "Hazardous Material" includes, without limitation, any material
or substance which is (i) designated as a "hazardous substance" pursuant to Section 1311 of the Federal Water Pollution
Control Act (33 U.S.C. Section 1317), (ii) defined as a “hazardous waste” pursuant to Section 1004 of the Federal Resource
Conservation and Recovery Act, 42 U.S.C. Section 6901 et seq. (42 U.S.C. Section 6903), (iii) defined as a "hazardous substance"
pursuant to Section 101 of the Comprehensive Environmental Response, Compensation and Liability Act, 42 U.S.C. Section 9601 et
seq. (42 U.S.C. Section 9601), (iv) defined as "hazardous substance" or "oil" under Chapter 21E of the General
Laws of Massachusetts, or (v) a so-called “biohazard” or medical waste, or is contaminated with blood or other bodily
fluids; and "Environmental Laws" include, without limitation, the laws listed in the preceding clauses (i) through (iv).

 

(d)          Any
increase in the premium for necessary insurance on the Premises or the Complex which arises from Tenant's use and/or storage of
these Hazardous Materials shall be solely at Tenant's expense. Tenant shall procure and maintain at its sole expense such additional
insurance as may be necessary to comply with any requirement of any federal, state or local government agency with jurisdiction.

 

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(e)          Tenant
hereby covenants and agrees to indemnify, defend and hold Landlord harmless from any and all claims, judgments, damages, penalties,
fines, costs, liabilities or losses (collectively "Losses") which Landlord may reasonably incur arising out of contamination
of real estate, the Complex or other property not a part of the Premises, which contamination arises as a result of: (i) the presence
of Hazardous Material in the Premises, the presence of which is caused or permitted by Tenant, or (ii) from a breach by Tenant
of its obligations under this Article 29.11. This indemnification of Landlord by Tenant includes, without limitation, reasonable
costs incurred in connection with any investigation of site conditions or any cleanup, remedial, removal or restoration work required
by any federal, state or local governmental agency or political subdivision because of Hazardous Material present in the soil or
ground water on or under the Premises based upon the circumstances identified in the first sentence of this Article 29.11(e). The
indemnification and hold harmless obligations of Tenant under this Article 29.11(e) shall survive any termination of this Lease.
Without limiting the foregoing, if the presence of any Hazardous Material in the Building or otherwise in the Complex caused or
permitted by Tenant results in any contamination of the Premises, Tenant shall promptly take all actions at its sole expense as
are necessary to return the Premises to a condition which complies with all Environmental Laws; provided that Landlord's approval
of such actions shall first be obtained, which approval shall not be unreasonably withheld so long as such actions, in Landlord's
reasonable discretion, would not potentially have any materially adverse long- term or short-term effect on the Premises, and,
in any event, Landlord shall not withhold its approval of any proposed actions which are required by applicable Environmental Laws.

 

(f)          On
or before the date that Tenant, and anyone claiming by, through or under Tenant, vacates the Premises, and immediately prior to
the time that Tenant delivers the Premises to Landlord, Tenant shall:

 

(1)         Cause
the Premises to be decommissioned in accordance with the regulations of the U.S. Nuclear Regulatory Commission and/or the Massachusetts
Department of Public Health for the control of radiation, cause the Premises to be released for unrestricted use by the Radiation
Control Program of the Massachusetts Department of Public Health for the control of radiation, and deliver to Landlord the report
of a certified industrial hygienist stating that he or she has examined the Premises (including visual inspection, Geiger counter
evaluation and airborne and surface monitoring) and found no evidence that such portion contains Hazardous Materials, as defined
in this Article 29.11, or is otherwise in violation of any Environmental Law, as defined in this Article 29.11 hereof.

 

(2)         Provide
to Landlord a copy of its most current chemical waste removal manifest and a certification from Tenant executed by an officer of
Tenant that no Hazardous Materials or other potentially dangerous or harmful chemicals brought onto the Premises from and after
the date that Tenant first took occupancy of the Premises remain in the Premises.

 

29.12      Patriot
Act.

 

Tenant represents and warrants to Landlord that:

 

(A)         Tenant
is not in violation of any Anti-Terrorism Law

 

(B)         Tenant
is not, as of the date hereof:

 

	 	(i)	conducting any business or engaging in any transaction or dealing with any Prohibited
Person (as hereinafter defined), including the making or receiving of any contribution of funds, goods or services to or for the
benefit of any Prohibited Person;

 

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		(ii)	dealing in, or otherwise engaging in any transaction relating to, any property or
interests in property blocked pursuant to Executive Order No. 13224; or

 

		(iii)	engaging in or conspiring to engage in any transaction that evades or avoids, or
has the purpose of evading or avoiding, or attempts to violate any of the prohibitions set forth in, any Anti-Terrorism Law; and

 

(C)         Neither
Tenant nor any of its affiliates, officers, directors, shareholders, members or lease guarantor, as applicable, is a Prohibited
Person.

 

If at any time any of these representations
becomes false, then it shall be considered a material default under this Lease.

 

As used herein, "Anti-Terrorism Law"
is defined as any law relating to terrorism, anti-terrorism, money-laundering or anti-money laundering activities, including without
limitation the United States Bank Secrecy Act, the United States Money Laundering Control Act of 1986, Executive Order No. 13224,
and Title 3 of the USA Patriot Act, and any regulations promulgated under any of them. As used herein "Executive Order No.
13224" is defined as Executive Order No. 13224 on Terrorist Financing effective September 24, 2001, and relating to “Blocking
Property and Prohibiting Transactions With Persons Who Commit, Threaten to Commit, or Support Terrorism", as may be amended
from time to time. "Prohibited Person" is defined as (i) a person or entity that is listed in the Annex to Executive
Order No. 13224, or a person or entity owned or controlled by an entity that is listed in the Annex to Executive Order No. 13224;
(ii) a person or entity with whom Landlord is prohibited from dealing or otherwise engaging in any transaction by any Anti-Terrorism
Law; or (iii) a person or entity that is named as a "specially designated national and blocked person" on the most current
list published by the U.S. Treasury Department Office of Foreign Assets Control at its official website, http://www.treas.gov/ofac/tl
lsdn.pdf or at any replacement website or other official publication of such list. "USA Patriot Act" is defined as the
"Uniting and Strengthening America by Providing Appropriate Tools Required to Intercept and Obstruct Terrorism Act of 2001"
(Public Law 107-56), as may be amended from time to time.

 

29.13         Letter
of Credit. In order to secure Tenant’s obligations to Landlord under this Lease, Tenant shall deliver to Landlord, on
the date that Tenant executes and delivers the Lease to Landlord, an Irrevocable Standby Letter of Credit ("Letter of Credit")
which shall be (1) in the form attached hereto as Exhibit 5, (2) issued by a bank reasonably acceptable to Landlord with minimum
assets of Ten Billion Dollars ($10,000,000,000.00), upon which presentment may be made in Boston, Massachusetts, (3) in an amount
equal to Twenty-Six Thousand One Hundred and Twenty-Nine and 65/100 ($26,129.65) Dollars, and (4) for a term of not less than
one (1) year, subject to extension in accordance with the terms of the Letter of Credit. Tenant shall, on or before the date thirty
(30) days prior to the expiration of the term of such Letter of Credit, deliver to Landlord a new Letter of Credit satisfying
the foregoing conditions ("Substitute Letter of Credit") in lieu of the Letter of Credit then being held by Landlord.
Such Letter of Credit shall be automatically renewable provided that if the issuer of such Letter of Credit gives notice of its
election not to renew such Letter of Credit for any additional period pursuant thereto, Tenant shall be required to deliver a
Substitute Letter of Credit satisfying the conditions hereof, on or before the date thirty (30) days prior to the expiration of
the term of such Letter of Credit. Tenant agrees that it shall from time to time, as necessary, whether as a result of a draw
on the Letter of Credit by Landlord pursuant to the terms hereof or as a result of the expiration of the Letter of Credit then
in effect, renew or replace the original and any subsequent Letter of Credit so that a Letter of Credit, in the amount required
hereunder, is in effect throughout term of this Lease, including any extensions thereof, or in the event that Tenant remains in
possession of the Premises following the expiration of the term, or if Tenant has obligations hereunder to Landlord that remain
unsatisfied following the expiration of the term (as may be extended), and for six (6) months after the latest to occur of the
foregoing (i.e., the expiration of the term (as may be extended), the date on which Tenant vacates and yields up the premises,
etc.). If Tenant fails to furnish such renewal or replacement at least 30 days prior to the stated expiration date of the Letter
of Credit then held by Landlord, Landlord may draw upon such Letter of Credit and hold the proceeds thereof (and such proceeds
need not be segregated) as a security deposit pursuant to the terms of this Article 29.13.

 

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In the event that Tenant is in default of its
obligations under the Lease beyond applicable notice and cure periods, then the Landlord shall have the right, at any time after
such event, without giving any further notice to Tenant, to draw down from said Letter of Credit (Substitute Letter of Credit or
Additional Letter of Credit, as defined below, as the case may be) (a) the amount necessary to cure such default or (b) if such
default cannot reasonably be cured by the expenditure of money, to exercise all rights and remedies Landlord may have on account
of such default, the amount which, in Landlord’s opinion, is necessary to satisfy Tenant’s liability on account thereof.
In the event of any such draw by the Landlord, Tenant shall, within fifteen (15) business days of written demand therefor, deliver
to Landlord an additional Letter of Credit satisfying the foregoing conditions ("Additional Letter of Credit"), except
that the amount of such Additional Letter of Credit shall be the amount of such draw. In addition, in the event of a termination
based upon the default of Tenant under the Lease, or a rejection of the Lease pursuant to the provisions of the Federal Bankruptcy
Code, Landlord shall have the right to draw upon the Letter of Credit (from time to time, if necessary) to cover the full amount
of damages and other amounts due from Tenant to Landlord under the Lease. Any amounts so drawn shall, at Landlord’s election,
be applied first to any unpaid rent and other charges which were due prior to the filing of the petition for protection under the
Federal Bankruptcy Code. Tenant hereby covenants and agrees not to oppose, contest or otherwise interfere with any attempt by Landlord
to draw down from said Letter of Credit including, without limitation, by commencing an action seeking to enjoin or restrain Landlord
from drawing upon said Letter of Credit. Tenant also hereby expressly waives any right or claim it may have to seek such equitable
relief. In addition to whatever other rights and remedies it may have against Tenant if Tenant breaches its obligations under this
paragraph, Tenant hereby acknowledges that it shall be liable for any and all damages which Landlord may suffer as a result of
any such breach.

 

Upon request of Landlord or any (prospective)
purchaser or mortgagee of the Building, Tenant shall, at its expense, cooperate with Landlord in obtaining an amendment to or replacement
of any Letter of Credit which Landlord is then holding so that the amended or new Letter of Credit reflects the name of the new
owner of the Building or mortgagee, as the case may be.

 

To the extent that Landlord has not previously
drawn upon any Letter of Credit, Substitute Letter of Credit, Additional Letter of Credit or Security Proceeds (collectively "Collateral")
held by the Landlord, and to the extent that Tenant is not otherwise in default of its obligations under the Lease as of the termination
date of the Lease, Landlord shall return such Collateral to Tenant on the termination of the term of the Lease.

 

In no event shall the proceeds of any Letter
of Credit be deemed to be a prepayment of rent nor shall it be considered as a measure of liquidated damages.

 

29.14         Parking.
Commencing as of the Term Commencement Date and continuing thereafter throughout the term of the Lease, the Landlord will
make available to Tenant four (4) monthly parking passes for use in the One Kendall Square Garage (the “Garage”) which
Landlord represents and warrants is owned in fee by it. Subject to availability, Tenant shall have the option to obtain additional
parking passes on a month-to-month basis and otherwise subject to the terms of this Section 29.14. Tenant shall have no right
to sublet, assign, or otherwise transfer said parking passes except in connection with an assignment of this Lease or sublease
of the Premises which is permitted pursuant to the provisions of this Lease. Said parking passes shall be paid for by Tenant at
the then current prevailing rate in the Garage, as such rate may vary from time to time; provided, however, in no event shall
the rate increase in any given year by more than 5% over the then current rate. The current rate for such passes as of the Execution
Date of this Lease is $225.00 per month. If, for any reason, Tenant shall fail timely to pay the charge for said parking passes,
Landlord shall have the same rights against Tenant as Landlord has with respect to the timely payment of Yearly Rent hereunder.
Said parking passes will be on an unassigned, non-reserved basis, and shall be subject to reasonable rules and regulations from
time to time in force. Tenant shall have the right, from time to time upon at least thirty (30) days prior written notice to Landlord,
to surrender one or more of such parking passes, and upon such surrender, Tenant shall have no further rights or obligations with
respect to such surrendered passes.

 

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29.15      Tenant’s
Option to Extend the Term of the Lease.

 

A.           On
the conditions, which conditions Landlord may waive, at its election, by written notice to Tenant at any time, that Tenant is not
in default of its covenants and obligations under the Lease, and that Enumeral Biomedical Corporation, itself, or a transferee
under Section 16.3 is occupying at least fifty percent (50%) of the Premises then demised to Tenant, both as of the time of option
exercise and as of the commencement of the hereinafter described additional term, Tenant shall have the option to extend the term
of this Lease for one (I) additional three (3) year term, such additional term commencing as of December 1, 2015 and expiring as
of November 30, 2018. Tenant may exercise such option to extend by giving Landlord written notice on or before March 1, 2015. Upon
the timely giving of such notice, the term of this Lease shall be deemed extended upon all of the terms and conditions of this
Lease, except that Landlord shall have no obligation to construct or renovate the Premises and that the Yearly Rent during such
additional term shall be as hereinafter set forth. If Tenant fails to give timely notice, as aforesaid, Tenant shall have no further
right to extend the term of this Lease, time being of the essence of this Article 29.15. If Tenant fails to timely exercise its
rights hereunder, then within seven (7) days of Landlord’s request therefor, Tenant shall execute and deliver to Landlord
a certification, in recordable form, confirming the Tenant’s failure to exercise (or waiver of) such right, and Tenant’s
failure to so execute and deliver such certification shall (without limiting Landlord’s remedies on account thereof) entitle
Landlord to execute and deliver to any third party, and record, an affidavit confirming the failure or waiver, which affidavit
shall be binding on Tenant and may be conclusively relied on by third parties.

 

B.           Yearly
Rent. The Yearly Rent during the additional term shall be based upon the Fair Market Rental Value, as defined in Article 29.16,
as of the commencement of the additional term, of the Premises then demised to Tenant.

 

C.           Tenant
shall have no further option to extend the term of the Lease other than the one (1) additional three (3) year term herein provided.

 

D.           Notwithstanding
the fact that, upon Tenant's exercise of the herein option to extend the term of the Lease, such extension shall be self executing,
as aforesaid, the parties shall promptly execute a lease amendment reflecting such additional term after Tenant exercises the herein
option, except that the Yearly Rent payable in respect of such additional term may not be set forth in said amendment. Subsequently,
after such Yearly Rent is determined, the parties shall execute a written agreement confirming the same. The execution of such
lease amendment shall not be deemed to waive any of the conditions to Tenant's exercise of its rights under this Article 29.15,
unless otherwise specifically provided in such lease amendment.

 

29.16      Definition
of Fair Market Rental Value.

 

A.           "Fair
Market Rental Value" shall be computed as of the date in question at the then current Yearly Rent, including provisions for
subsequent increases and other adjustments for leases or agreements to lease then currently being negotiated, or executed in comparable
space located in the Complex, or if no such leases or agreements to lease are then currently being negotiated or executed in the
Complex, the Fair Market Rental Value shall be determined by reference to leases or agreements to lease then currently being negotiated
or executed for comparable space located elsewhere in first-class office buildings located in East Cambridge, Massachusetts. In
determining Fair Market Rental Value, all relevant factors shall be taken into account and given effect, including, without limitation:
size, location and condition of Premises, lease term, including renewal options, tenant’s obligations with respect to operating
expenses and taxes, tenant improvement allowances, condition of building, and services and amenities provided by the Landlord.

 

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B.           Dispute
as to Fair Market Rental Value:

 

Landlord shall initially designate Fair Market
Rental Value and Landlord shall furnish data in support of such designation. If Tenant disagrees with Landlord's designation of
a Fair Market Rental Value, Tenant shall notify Landlord, by written notice given within thirty (30) days after Tenant has been
notified of Landlord's designation, of its disagreement whereupon the parties shall negotiate in good faith to arrive at a mutually
agreeable Fair Market Rental Value. If the parties are unable to agree within thirty (30) days after Tenant’s notice to Landlord,
the parties shall submit such Fair Market Rental Value to arbitration. Fair Market Rental Value shall be submitted to arbitration
as follows: Fair Market Rental Value shall be determined by impartial arbitrators, one to be chosen by the Landlord, one to be
chosen by Tenant, and a third to be selected, if necessary, as below provided. The unanimous written decision of the two first
chosen, without selection and participation of a third arbitrator, or otherwise, the written decision of a majority of three arbitrators
chosen and selected as aforesaid, shall be conclusive and binding upon Landlord and Tenant. Landlord and Tenant shall each notify
the other of its chosen arbitrator within ten (10) days following the call for arbitration and, unless such two arbitrators shall
have reached a unanimous decision within thirty (30) days after their designation, they shall so notify the President of the Boston
Bar Association (or such organization as may succeed to said Boston Bar Association) and request him or her to select an impartial
third arbitrator. All arbitrators shall have at least ten (10) years of professional experience as an office building owner, real
estate manager or real estate broker dealing with like types of properties, to determine Fair Market Rental Value as herein defined.
Such third arbitrator and the first two chosen shall, subject to commercial arbitration rules of the American Arbitration Association,
hear the parties and their evidence and render their decision within thirty (30) days following the conclusion of such hearing
and notify Landlord and Tenant thereof. Landlord and Tenant shall bear the expense of the third arbitrator (if any) equally. The
decision of the arbitrators shall be binding and conclusive, and judgment upon the award or decision of the arbitrators may be
entered in the appropriate court of law (as identified on Exhibit 1); and the parties consent to the jurisdiction of such court
and further agree that any process or notice of motion or other application to the Court or a Judge thereof may be served outside
the Commonwealth of Massachusetts by registered mail or by personal service, provided a reasonable time for appearance is allowed.
If the dispute between the parties as to a Fair Market Rental Value has not been resolved before the commencement of Tenant's obligation
to pay rent based upon such Fair Market Rental Value, then Tenant shall pay Yearly Rent and other charges under the Lease in respect
of the Premises in question based upon the Fair Market Rental Value designated by Landlord until either the agreement of the parties
as to the Fair Market Rental Value, or the decision of the arbitrators, as the case may be, at which time Tenant shall pay any
underpayment of rent and other charges to Landlord, or Landlord shall refund any overpayment of rent and other charges to Tenant.

 

[signatures appear on next page]

 

    	-43-

    	 

    

 

IN WITNESS WHEREOF the parties hereto have executed
this Indenture of Lease in multiple copies, each to be considered an original hereof, as a sealed instrument on the day and year
noted in Exhibit 1 as the Execution Date.

 

	LANDLORD:	 	TENANT:
	 	 	 
	RB KENDALL FEE, LLC	 	ENUMERAL BIOMEDICAL CORP.
	 	 	 
	By:	/s/ Robert L. Beal	 	By:	/s/ Arthur Tinkelenberg
	Name:  Robert L. Beal 	 	(Name) Arthur Tinkelenberg
	Title:   Its Authorized Signatory	 	(Title) President & CEO
	 	 	Hereunto Duly Authorized

 

IF TENANT IS A CORPORATION, A SECRETARY’S
OR CLERK’S CERTIFICATE OF THE AUTHORITY AND THE INCUMBENCY OF THE PERSON SIGNING ON BEHALF OF TENANT SHOULD BE ATTACHED.

 

    	-44-

    	 

    

 

EXHIBIT 2

LEASE PLAN

 

 

 

    	-45-

    	 

    

 

EXHIBIT 2A

TENANT’S WORK LETTER

 

THIS WORK LETTER (the “Work Letter”)
is attached to and made part, of that certain Lease (the “Lease”) by and between RB BEAL KENDAL FEE, LLC (“Landlord”)
and ENUMERAL BIOMEDICAL CORPORATION (“Tenant”). The terms, definitions, and other provisions of the Lease are hereby
incorporated into this Work Letter by reference as if set forth in full. Capitalized terms used herein but not defined in this
Work Letter shall have the meanings set forth in the Lease. In connection with the execution of the Lease, Landlord and Tenant
hereby agree as follows

 

1.          Tenant’s
Work. Tenant, at its sole cost and expense, but subject to the Improvement Allowance (as defined below), shall cause the Substantial
Completion (as defined below) of the leasehold improvement work necessary to prepare the Premises for the use and occupancy by
Tenant (with the exception of Landlord’s Work as defined in the Lease) in accordance with Tenant’s Plans (as defined
below) (“Tenant’s Work”). All construction work and installations conducted in connection with Tenant’s
Work shall be done in a good and workmanlike manner with new, first-class materials and finishes equal to or better than Building
standard construction materials and finishes, in a lien-free manner and in compliance with all local, state and federal requirements,
and all requirements of public authorities and insurance bodies related to, or arising out of the performance of, such construction
work and the terms and conditions of this Work Letter (and applicable provisions of the Lease).

 

2.          Plans
for the Tenant’s Work; Contractor Approval. Tenant’s Work shall be in conformity with plans and specifications
submitted to and approved by Landlord, and constructed by a contractor approved by Landlord, in accordance with the following provisions:

 

a.           On
or before the date that is seven (7) days after the Execution Date of this Lease, Tenant shall prepare and submit to Landlord for
its approval two (2) sets of fully dimensioned scale plans and specifications (suitable for submission with a building permit application)
for Tenant’s Work (including plans, elevations, critical sections and details and as otherwise provided in the Lease) (“Tenant’s
Plans”). Tenant’s Plans shall be prepared by a licensed architect and where appropriate, mechanical, electrical and
structural engineers, reasonably approved by Landlord. “Tenant’s Contractor” and “Tenant’s Architect”
shall be subject to Landlord’s reasonable approval. Throughout the approval process for Tenant’s Plans, Tenant shall
use commercially reasonable and diligent efforts to cooperate with Landlord and/or Landlord’s architect or engineer in responding
to questions or requests for information or submissions regarding Tenant’s design requirements for the Tenant’s Work.
Landlord’s approval of Tenant’s Plans (or any requested modification, amendment or alteration thereto) shall not be
unreasonably withheld, conditioned or delayed so long as such plans do not (i) require any modification to any existing permits
and approvals obtained by Landlord in connection with the Building, (ii) involve changes to structural components of the Building
nor involve any material floor or exterior wall penetrations, or (iii) not require any material modifications of the Building’s
mechanical, electrical, plumbing, fire or life-safety systems. All construction work done by or on behalf of Tenant, on or to the
Premises (including the Tenant’s Work) causing roof penetrations shall, at Landlord’s request, be performed by or supervised
by Landlord’s roofing contractor, or by a contractor otherwise approved by Landlord, and at Tenant's expense, in such a way
so as to not void any roof warranties or guaranties, provided the amount charged by such contractor for such work is competitive
to the amount that would be charged by other reputable contractors performing the same scope of work.

 

    	-46-

    	 

    

 

b.           Within
seven (7) business days after receipt of Tenant’s Plans (unless the response reasonably requires a longer time), Landlord
shall return one set of prints thereof with Landlord’s approval and/or required modifications noted thereon. Landlord shall
also identify any components of Tenant’s Work which Landlord will require to be removed at the expiration of the Term or
earlier termination of the Lease. If Landlord has approved Tenant’s Plans subject to modifications, such modifications shall
be deemed to be acceptable to and approved by Tenant unless Tenant shall prepare and resubmit revised plans for further consideration
by Landlord within seven (7) business days. If Landlord has required modifications without approving Tenant’s Plans, Tenant
shall prepare and resubmit revised drawings within seven (7) business days for consideration by Landlord. All revised plans shall
be submitted, with changes highlighted, and Landlord shall approve or disapprove such revised drawings within five (5) business
days following receipt of the same. The foregoing submission process shall continue until Landlord has approved Tenant’s
Plans and upon such approval, the approved plans shall constitute the “Tenant’s Plans.” Any approval granted
by Landlord hereunder shall be granted solely for the benefit of Landlord, and neither Tenant nor any third party shall have the
right to rely upon Landlord’s approval of any of the Tenant’s Plans for any other purpose whatsoever and Landlord assumes
no responsibility whatsoever, and shall not be liable, for the manufacturer’s, architect’s, or engineer’s design
or performance of any structural, mechanical, electrical, or plumbing systems or equipment of Tenant relating to the Tenant’s
Work or Tenant’s Plans. Without limiting the foregoing, Tenant shall be responsible for all elements of the design of Tenant’s
Work (including, without limitation, the compliance of the Tenant’s Work and Tenant’s Plans with local, state and federal
requirements, functionality of design, the structural integrity of the design, the configuration of the Premises,, and the placement
of Tenant’s furniture, appliances and equipment), and Landlord’s approval of the Tenant’s Plans shall in no event
relieve Tenant of the responsibility therefor. Notwithstanding the time periods permitted for either party’s review of Tenant’s
Plans, both parties agree to use reasonable efforts to complete such review as soon as practical.

 

c.           Upon
Landlord’s approval of Tenant’s Plans, Tenant shall not materially modify, amend or alter Tenant’s Plans without
Landlord’s prior written approval during the construction process and (unless the response reasonably requires a longer time),
Landlord shall respond within five (5) business days to Tenant’s request. Any material changes in the Tenant’s Work
from Tenant’s Plans as approved by Landlord shall be subject to Landlord’s prior written approval. Any deviation (other
than immaterial changes that do not affect the quality or nature of the improvements or require an alteration in any Building mechanical,
electrical, plumbing, fire or life-safety systems or Landlord’s permits and approvals) in construction from the design specifications
and criteria set forth in Tenant’s Plans as approved by Landlord shall, at Landlord’s election, constitute a default
for which Landlord may, after any applicable grace period, elect to exercise the remedies available in the event of default under
the provisions of this Lease, unless such default is cured in accordance with and in the time periods set forth in the Lease.

 

d.           Tenant’s
Plans shall include detailed drawings and specifications for the design and installation of Tenant’s fire alarm and security
system(s) for the Premises. Such system(s) shall meet all appropriate building code requirements, and the fire alarm and security
systems shall, at Tenant’s expense, be integrated into, and in operational harmony with, Landlord’s fire alarm and
security systems for the Building. Unless otherwise authorized or approved by Landlord in writing, Landlord’s electrical
contractor and/or fire alarm contractor shall, at Tenant’s expense, make all final connections between Tenant’s and
Landlord’s fire alarm and security systems, provided the amount charged by such contractor for such work is competitive to
the amount that would be charged by other reputable contractors performing the same scope of work. Tenant shall ensure that all
work performed on the fire alarm and security system(s) shall be coordinated at the job site with the Landlord’s representative.

 

e.           Upon
the deliveiy of the Premises to Tenant and after final approval of Tenant’s Plans by Landlord, Tenant shall proceed to commence
and diligently complete construction of Tenant’s Work in accordance with Tenant’s Plans and this Work Letter. Tenant’s
contractors and subcontractors shall be licensed and be acceptable to and approved in writing by Landlord, which approval shall
not be unreasonably withheld, conditioned or delayed, and shall, at Landlord’s option, be subject to administrative supervision
by Landlord , at Landlord’s sole cost and expense, in their use of the Building. Tenant shall furnish to Landlord a copy
of the executed contract and applicable detailed cost schedule (and applicable back-up material as reasonably requested by Landlord)
between Tenant and Tenant’s Contractor covering all of Tenant’s obligations under this Work Letter. Tenant shall use
commercially reasonable efforts to cause such work to be performed in as efficient a manner as is commercially reasonable. Tenant
shall indemnity Landlord from and reimburse Landlord on demand for the cost of repairing any damage to the Building caused by Tenant
or its contractors during performance of the Tenant’s Work. Tenant’s Contractor(s) shall conduct their work and employ
labor in such manner as to maintain harmonious labor relations and to coordinate their activities with Landlord’s contractors
so as not to interfere with Landlord or any other tenant or occupant of the Building. Any work to be performed outside of the Premises
shall be coordinated with Landlord, and shall be subject to reasonable scheduling requirements of Landlord.

 

    	-47-

    	 

    

 

f.            Tenant
acknowledges that it has engaged (or shall engage) its architects and contractors and Tenant shall be solely responsible for the
actions and omissions of its architects and contractors or for delays caused by its architects or contractors. Landlord’s
approval of any of Tenant’s architects or contractors and of any documents prepared by any of them, including but not limited
to Tenant’s Plans, shall not be for the benefit of Tenant or any third party or be construed as a representation or warranty
as to the suitability or legal compliance of same, and Landlord shall have no duty to Tenant or to any third parties for the actions
or omissions of Tenant’s architects or contractors. Tenant shall indemnify and hold harmless Landlord against any and all
losses, costs, damages, claims and liabilities arising from the actions or omissions of Tenant’s architects and contractors,

 

g.           Notwithstanding
anything to the contrary contained in this Exhibit of this Lease, Landlord agrees that Tenant shall not be required to remove any
of Tenant’s Work completed in accordance with Landlord approved Tenant Plans upon the expiration or earlier termination of
this Lease.

 

3.          Permits
and Approvals. Tenant shall obtain all building and other permits and approvals necessary to perform the construction and installation
of the Tenant’s Work prior to the commencement of such work. The Tenant’s Work shall not (a) require any modification
to any existing permits and approvals obtained by Landlord in connection with the Building, (b) not involve changes to structural
components of the Building nor involve any floor, or exterior wall penetrations unless approved by Landlord, or (c) not require
any material modifications of the Building’s mechanical, electrical, plumbing, fire or life-safety systems unless approved
by Landlord,

 

4.          Prior
to Commencing the Tenant’s Work. Prior to commencing the Tenant’s Work, Tenant shall deliver to Landlord (in addition
to any other requirements under the Lease) the following:

 

a.           The
address of Tenant’s Contractor(s), and the names of the primary subcontractors Tenant’s Contractor intends to engage
for the construction of the Tenant’s Work and Notices of Identification from each such entity pursuant to M.G.L. c.254, §4.

 

b.           The
estimated commencement date of construction and the estimated date of completion of Tenant’s Work, including fixturization.

 

c.           Certificates
or policies of insurance evidencing that Tenant and Tenant’s Contractor(s) have in effect (and shall maintain at all times
during the course of the construction of Tenant’s Work hereunder) the insurance coverages required under the Lease.

 

d.           An
executed copy of the applicable building permit(s) for such work.

 

5.          Temporary
Connections: Trash: Other Costs. During the construction of the Tenant’s Work, Landlord shall provide and pay for connections
for all utilities brought to the Premises, if required. Trash removal relating to the Tenant’s Work will be done continually
at Tenant’s sole cost and expense. No trash, or other debris, or other waste may be deposited at any time outside the Premises
or Building by Tenant or its contractor. If so, Landlord may remove it at Tenant’s expense, which expense shall equal the
cost of removal plus twenty percent (20%) of such costs. Tenant shall be responsible for paying such costs and expenses relating
to testing or re-setting Building systems as may be required during construction and for ensuring that Tenant’s Contractors,
subcontractors and their respective employees do not park in tenant or Building parking facilities.

 

    	-48-

    	 

    

 

6.          Storage:
Release and Indemnity: MSDS. Storage of Tenant’s contractors’ construction materials, tools and equipment shall
be confined within the Premises in an area or areas designated by Landlord, and in no event shall any materials or debris be stored
outside of the Premises or Building. To the extent Tenant’s equipment, fixtures, furniture, furnishings or other materials
are stored or installed in the Premises prior to the Term Commencement Date by Tenant or its agents, Tenant hereby releases Landlord
for any and all liability therefor and agrees to indemnify and hold Landlord harmless from and against any and all liability, loss,
claim, cause of action, damages, cost or expense arising out of or in connection with loss or damage or destruction of any such
equipment, fixtures, furnishings or other materials, unless such loss, damage or destruction is caused by the negligence or willful
misconduct of Landlord or its agents. Tenant shall cause its contractors to provide Landlord with Material Safety Data Sheets (MSDS)
for all chemicals and substances they propose to use on, at, in or about the Premises, which use shall be subject to the reasonable
approval of Landlord.

 

7.          Performance
of Tenant’s Work. Tenant shall take all reasonably necessary measures to maintain harmonious labor relations at the Building
and to ensure that Tenant’s Contractor (and subcontractors) and any contractors utilized by Landlord or other tenants of
the Building cooperate in all commercially reasonable ways. In addition, if construction during normal construction hours unreasonably
and materially disturbs other tenants in the Building, in Landlord’s reasonable discretion, Landlord may require Tenant to
stop performance of those portions of Tenant’s Work so disturbing other tenants during normal construction hours and to perform
the same after normal construction hours.

 

8.          Substantial
Completion. As used herein the term “Substantial Completion” or “substantially complete” shall mean
that the applicable work (i.e., the Tenant’s Work or Landlord’s Work) shall have been completed in accordance
with the requirements of the Lease except for details of construction, decoration and mechanical adjustments which are minor in
character and, in the case of Landlord’s Work, the non-completion of which do not unreasonably interfere with the construction
of Tenant’s Work (collectively, “punchlist items”) and (ii) that, in the case of Tenant’s Work, a certificate
of occupancy (temporary or permanent) or a fully-signed off building permit for the Premises issued by the City of Cambridge (the
“Certificate of Occupancy”) permitting the use of the Premises is available or has been issued, and that such work
is otherwise substantially complete but the Certificate of Occupancy cannot be issued because the other party’s work is not
substantially complete.

 

9.          Upon
Completion. Upon completion of the Tenant’s Work, Tenant shall furnish Landlord:

 

a.           Certificate
of Occupancy issued by the City of Cambridge and other governmental approvals, if any, necessary to permit occupancy of the Premises
for the Permitted Uses.

 

b.           A
notarized affidavit from Tenant’s contractor(s) that all amounts due for work done and materials furnished in completing
Tenant’s Work have been paid.

 

c.           Final
releases of liens satisfactory in form and substance to Landlord from all contractors, subcontractors or material suppliers that
have been involved in the performance of the Tenant’s Work.

 

d.           two
(2) complete sets of as-built plans (one (1) reproducible CAD file) and specifications covering all of the Tenant’s Work,
including architectural, electrical, and plumbing, with a list and description of all work performed by the contractors, subcontractors,
and material suppliers, with all changes or modifications listed thereon.

 

10.         Damage
to Base Building. Tenant shall also be responsible for the cost of any alterations to the Building required as a result of
the Tenant’s Work. Any damage to the existing finishes of the Building shall be patched and repaired by Tenant, at its expense,
and all such work shall be done to Landlord’s reasonable satisfaction. If any patched and painted area does not match the
original surface, then the entire surface shall be repainted at Tenant’s expense. Tenant agrees to indemnify and hold harmless
Landlord, its agents, and employees from and against any and all costs, expenses, damage, loss, or liability, including, but not
limited to, reasonable attorneys’ fees and costs, which arise out of, is occasioned by, or is in any way attributable to
the build-out of the Premises by Tenant pursuant to this Work Letter.

 

    	-49-

    	 

    

 

11.         Payment
of Costs for Tenant’s Work; Improvement Allowance. Subject to the Improvement Allowance set forth herein, Tenant shall
pay all of the costs and expenses of the Tenant’s Work (which cost shall include, without limitation, the costs of construction,
the cost of permits and permit expediting, and all architectural and engineering services obtained by Tenant in connection therewith).
Landlord will provide Tenant an allowance (the “Improvement Allowance”) up to a maximum of $47,820.00 ($10,00 per
square foot of Rentable Area of the Premises). The Improvement Allowance shall be utilized for so-called “hard” costs
and building improvements to the Premises pursuant to Tenant’s Plans, for so-called “soft” costs limited to
architectural and design costs and construction management fees (if any) and expressly not used towards portable fixtures, trade
equipment, furnishings, office furniture, wiring and other special purpose items and equipment). So long as Tenant is not in default
of the Lease beyond any applicable notice and cure period, payment of the Improvement Allowance shall be paid by Landlord to Tenant
in one (1) lump sum payment based upon a request for payment submitted by Tenant upon the completion of Tenant’s Work. Such
request for payment shall be accompanied by a written certification satisfactory to Landlord by Tenant’s Architect that
all work has been completed, along with the applicable items required under Section 9, above, along with any other support documentation
reasonably required by Landlord in connection therewith, provided, however, that the Improvement Allowance (or a suitable portion
thereof) may not be released by Landlord if any liens, notices of contract or similar instruments relating to Tenant’s Work
exist or appear in the record title to the Building or Complex. Any and all costs for the construction of the Premises above the
Improvement Allowance shall be paid by Tenant to the applicable contractors, subcontractors, and material suppliers. Landlord
reserves the right to make any payment (or portion thereof) of the Improvement Allowance payable jointly to Tenant and its general
contractor (or subcontractor or supplier) or directly to such contractor, subcontractor or supplier. Landlord shall be entitled
to deduct from the Improvement Allowance the construction management fee, to the extent applicable, and all direct, out-of-pocket
expenses incurred by Landlord in reviewing and approving the Tenant’s Plans.

 

12.         Punchlist.
In or within seven (7) business days of Substantial Completion of the Tenant’s Work, the parties shall schedule a meeting(s)
to jointly inspect the Premises and the Tenant’s Work in order to identify those incomplete items or unfinished details that
will be part of the punchlist for the Tenant’s Work. Such punchlist items shall be completed by Tenant’s Contractor
as soon as practicable thereafter and in any event not later than thirty (30) days following the completion of the punchlist (except
for such item(s) that by its nature or due to circumstances beyond the reasonable control of the party charged with doing such
work, cannot be completed within such 30 day period).

 

    	-50-

    	 

    

 

EXHIBIT 3

PLAN OF COMPLEX

 

 

  

    	-51-

    	 

    

 

EXHIBIT 4

TERM COMMENCEMENT DATE AGREEMENT

 

__________________ (“Tenant”) hereby
certifies that it has entered into a lease with RB KENDALL FEE, LLC (“Landlord”) dated ________________, 20__ [,
as amended by ________________ dated _________, 20 ___,] and verifies the following information as of the _____
day of ________________, 200 __:

  

	Address of Building:	Building ____, One Kendall Square, Cambridge, MA 02139
	 	 
	Number of Rentable Square Feet in Premises:	_________ r.s.f.
	 	 
	Term Commencement Date:	__________________, 20__
	 	 
	Rent Commencement Date:	__________________, 20__
	 	 
	Lease Termination Date:	__________________, 20__
	 	 
	Tenant’s Proportionate Common Share:	___%
	 	 
	Tenant’s Proportionate Building Share:	___%

 

Tenant acknowledges and agrees that all improvements
Landlord is obligated to make to the Premises, if any, have been completed to Tenant’s satisfaction, that Tenant has accepted
possession of the Premises, and that as of the date hereof, there exist no offsets or defenses to the obligations of Tenant under
the Lease.

 

	TENANT:	 	LANDLORD:
	 	 	 	 
	 	 	 	RB KENDALL FEE, LLC
	 	 	 	 
	By:	 	 	By:	/s/ Robert L. Beal
	Name:	 	 	Name: Robert L. Beal
	Title:	 	 	Title: Its Authorized Signatory
	Hereunto duly authorized	 	 

 

    	-52-This LOAN AND SECURITY AGREEMENT (the
“Agreement”) is entered into as of December 1, 2011, by and between Square 1 Bank (“Bank”) and Enumeral
Biomedical Corp. (“Borrower”).

 

RECITALS

 

Borrower wishes to obtain credit from
time to time from Bank, and Bank desires to extend credit to Borrower. This Agreement sets forth the terms on which Bank will advance
credit to Borrower, and Borrower will repay the amounts owing to Bank.

 

AGREEMENT

 

The parties agree as follows:

 

1.           DEFINITIONS
AND CONSTRUCTION.

 

1.1         Definitions.
As used in this Agreement, all capitalized terms shall have the definitions set forth on Exhibit A. Any term used in the Code
and not defined herein shall have the meaning given to the term in the Code.

 

1.2         Accounting
Terms. Any accounting term not specifically defined on Exhibit A shall be construed in accordance with GAAP and all calculations
shall be made in accordance with GAAP (except for non-compliance with FAS 123R in monthly reporting). The term “financial
statements” shall include the accompanying notes and schedules.

 

2.           LOAN
AND TERMS OF PAYMENT.

 

2.1         Credit
Extensions.

 

(a)          Promise
to Pay. Borrower promises to pay to Bank, in lawful money of the United States of America, the aggregate unpaid principal amount
of all Credit Extensions made by Bank to Borrower, together with interest on the unpaid principal amount of such Credit Extensions
at rates in accordance with the terms hereof.

 

(b)          Term
Loan A.

 

(i)          Subject
to and upon the terms and conditions of this Agreement, Bank agrees to make one (1) term loan to Borrower in an aggregate principal
amount of the Term Loan A Amount (“Term Loan A”). Borrower agrees to request Term Loan A on the Term Loan A Availability
End Date. The proceeds of the Term Loan A shall be used for general working capital purposes and for capital expenditures.

 

(ii)         Interest
shall accrue from the date of Term Loan A at the rate specified in Section 2.3(a), and prior to the Term Loan A Interest-Only End
Date interest only shall be payable monthly beginning on January 1, 2011, and continuing on the same day of each month thereafter.
If Term Loan A remains outstanding on the Term Loan A Interest-Only End Date, it shall be payable in 30 equal monthly installments
of principal, plus all accrued interest, beginning on one month immediately following the Term Loan A Interest-Only End Date,
and continuing on the same day of each month thereafter through the Term Loan A Maturity Date,
at which time all amounts due in connection with the Term Loan A shall be immediately due and payable. Term Loan A, once repaid,
may not be re-borrowed.

 

    	1.

    	 

    

(iii)        On
the Term Loan A Availability End Date, Borrower shall confirm to
Bank (which notice shall be irrevocable) by facsimile transmission to be received no later than 3:30 p.m. Eastern time that Borrower
desires to obtain Term Loan A. Such confirmation shall be substantially in the form of Exhibit C. The confirmation shall be signed
by an Authorized Officer.

 

(c)          Term
Loan B.

 

(i)          Subject
to and upon the terms and conditions of this Agreement, Bank agrees to make one (1) term loan to Borrower
in an aggregate principal amount of the Term Loan B Amount (“Term Loan B”). Borrower may request Term Loan
B at any time from the date hereof through the Term Loan B Availability End Date. The proceeds of Term Loan B shall be used for
general working capital purposes and for capital expenditures.

 

(ii)         Interest
shall accrue from the date of Term Loan B at the rate specified in Section 2.3(a), and prior to the Term Loan B Interest-Only
End Date for the applicable Term Loan B interest only shall be payable monthly beginning on the first day of the month next following
such Term Loan B, and continuing on the same day of each month thereafter. If Term Loan B remains outstanding on the Term Loan
B Interest-Only End Date, it shall be payable in 30 equal monthly installments of principal, plus all accrued interest, beginning
on one month immediately following the Term Loan B Interest-Only End Date, and continuing on the same day of each month thereafter
through the Term Loan B Maturity Date, at which time all amounts due in connection with the Term Loan B and any other amounts
due under this Agreement shall be immediately due and payable. Term Loan B, once repaid, may not be re-borrowed.

 

(iii)        When
Borrower desires to obtain Term Loan B, Borrower shall notify Bank (which notice shall be irrevocable) by facsimile transmission
to be received no later than 3:30 p.m. Eastern time on the day on which the Term Loan B is to be made. Such notice shall be substantially
in the form of Exhibit C. The notice shall be signed by an Authorized Officer and include evidence to Bank that Borrower has received
the New Equity in its entirety.

 

(d)          Equipment
Advances.

 

(i)          Subject
to and upon the terms and conditions of this Agreement, Bank agrees
to make Equipment Advances to Borrower. Borrower may request, and, subject to terms and conditions hereof, the satisfaction of
which shall be determined in good faith by Bank in its sole discretion, Bank will fund Equipment Advances at any time from the
date hereof through the Equipment Availability End Date. The aggregate outstanding amount of Equipment Advances shall not exceed
the Equipment Loan.

 

    	2.

    	 

    

 

(ii)         For
Equipment purchased by Borrower within 90 days of the date of the corresponding Equipment Advance, each Equipment Advance shall
not exceed 100.0% (the “Equipment Advance Rate”) of the invoice amount of equipment and software approved by Bank from
time to time, excluding any portion of Soft Costs that exceed of 10.0% of the Equipment Advance; provided however, that the Equipment
Advance Rate shall be decreased by 25.0% for Equipment aged 91-120 days from the invoice date and such Equipment Advance Rate shall
be further decreased by an additional 5.0% for each additional 30 days (or any part thereof) beyond 120 days from the invoice date;
and provided further however, that the Equipment Advance Rate applicable to the initial Equipment Advance shall not be subject
to the aforementioned discounting process if such Equipment Advance: (i) pertains to the approximately $590,000 of Equipment acquired
by the Borrower between May 1, 2011 and the Closing Date, (ii) occurs on or about the Closing Date, and (iii) the Closing Date
is on or before October 31, 2011. The Equipment Advance Rate and the eligibility of all Equipment as the basis for future Equipment
Advances are subject to modification in the Bank’s sole discretion based on Bank’s review of the Collateral.

 

(iii)        Interest
shall accrue from the date of each Equipment Advance at the rate specified in Section 2.3(a), and prior to the Equipment Interest-Only
End Date interest only shall be payable monthly beginning on the first day of the month next following the Equipment Advance, and
continuing on the first day of each month thereafter. Any Equipment Advances that are outstanding on the Equipment Interest-Only
End Date shall be payable in 30 equal monthly installments of principal, plus all accrued interest, beginning on the date one (1)
month immediately following the Equipment Interest-Only End Date, and continuing on the same day of each month thereafter through
the Equipment Maturity Date, at which time all amounts due in connection with the Equipment Advance shall be immediately due and
payable. Equipment Advances, once repaid, may not be reborrowed. Borrower may prepay any Equipment Advances without penalty or
premium.

 

(iv)        When
Borrower desires to obtain an Equipment Advance, Borrower shall notify Bank (which notice shall be irrevocable) by facsimile transmission
to be received no later than 3:00 p.m. Eastern time three Business Days before the day on which the Equipment Advance is
to be made. Such notice shall be substantially in the form of Exhibit C. The notice shall be signed by a Responsible Officer or
its designee and include a copy of the invoice for any Equipment to be financed.

 

2.2         Intentionally
Left Blank.

 

2.3         Interest
Rates, Payments, and Calculations.

 

(a)          Interest
Rates.

 

(i)          Equipment
Advances. Except as set forth in Section 2.3(b), the Equipment Advances shall bear interest, on the outstanding daily balance
thereof, at a variable annual rate equal to the greater of: (A) 3.75% above the Prime Rate then in effect; or (B) 7.00%; provided
however, subject to the condition that no Event of Default has occurred hereunder, that the annual rate shall not exceed 8.50%
during the first 18 months after the Closing Date and shall not exceed 9.50% thereafter.

 

    	3.

    	 

    

 

(ii)          Term
Loans. Except as set forth in Section 2.3(b), the Term Loans shall bear interest, on the outstanding daily balance thereof,
at a variable annual rate equal to the greater of: (A) 3.75% above the Prime Rate then in effect; or (B) 7.00%; provided however,
subject to the condition that no Event of Default has occurred hereunder, that the annual rate shall not exceed 8.50% during the
first 18 months after the Closing Date and shall not exceed 9.50% thereafter.

 

(a)          Late
Fee; Default Rate. If any payment is not made within 15 days after the date such payment is due, Borrower shall pay Bank a
late fee equal to the lesser of (i) 5% of the amount of such unpaid amount or (ii) the maximum amount permitted to be charged under
applicable law. All Obligations shall bear interest, from and after the occurrence and during the continuance of an Event of Default,
at a rate equal to 5 percentage points above the interest rate applicable immediately prior to the occurrence of the Event of Default.

 

(b)          Payments.
Bank shall, at its option, charge such interest, all Bank Expenses, and all Periodic Payments against any of Borrower’s
deposit accounts. Any interest not paid when due shall be compounded by becoming a part of the Obligations, and such interest shall
thereafter accrue interest at the rate then applicable hereunder.

 

(c)          Computation.
In the event the Prime Rate is changed from time to time hereafter, the applicable rate of interest hereunder shall be increased
or decreased, effective as of the day the Prime Rate is changed, by an amount equal to such change in the Prime Rate. All interest
chargeable under the Loan Documents shall be computed on the basis of a 360 day year for the actual number of days elapsed.

 

2.4         Crediting
Payments. Prior to the occurrence of an Event of Default, Bank shall credit a wire transfer of funds, check or other item of
payment to such deposit account or Obligation as Borrower specifies, except that to the extent Borrower uses the Equipment Advances/Term
Loans to purchase Collateral, Borrower’s repayment of the Equipment Advances/Term Loans shall apply on a “first-in-first-out”
basis so that the portion of the Equipment Advances/Term Loans used to purchase a particular item of Collateral shall be paid in
the chronological order the Borrower purchased the Collateral. After the occurrence and during the continuance of an Event of Default,
Bank shall have the right, in its sole discretion, to immediately apply any wire transfer of funds, check, or other item of payment
Bank may receive to conditionally reduce Obligations, but such applications of funds shall not be considered a payment on account
unless such payment is of immediately available federal funds or unless and until such check or other item of payment is honored
when presented for payment. Notwithstanding anything to the contrary contained herein, any wire transfer or payment received by
Bank after 5:30 p.m. Eastern time shall be deemed to have been received by Bank as of the opening of business on the immediately
following Business Day. Whenever any payment to Bank under the Loan Documents would otherwise be due (except by reason of acceleration)
on a date that is not a Business Day, such payment shall instead be due on the next Business Day, and additional fees or interest,
as the case may be, shall accrue and be payable for the period of such extension.

 

    	4.

    	 

    

 

2.5           Fees.
Borrower shall pay to Bank the following:

 

(a)          Facility
Fee. On or before the Closing Date, a fee equal to $10,000, which shall be nonrefundable;

 

(b)          Bank
Expenses. On the Closing Date, all Bank Expenses incurred through the Closing Date, and, after the Closing Date, all Bank
Expenses, as and when they become due.

 

(c)          Prepayment
Fee. In the event Borrower prepays all or a portion of any Term Loans prior to the Term Loan Maturity Date, Borrower shall,
simultaneous with any such prepayment, pay Bank a fee of: (i) 3.0% of the aggregate principal amount so prepaid if such prepayment
occurs during the first year after the Closing Date; (ii) 2.0% of the aggregate principal amount so prepaid if such prepayment
occurs during the second year after the Closing Date; or (iii) 1.0% of the aggregate principal amount so prepaid if such prepayment
occurs during the third year after the Closing Date.

 

2.6           Term.
This Agreement shall become effective on the Closing Date and, subject to Section 12.7, shall continue in full force and effect
for so long as any Obligations remain outstanding or Bank has any obligation to make Credit Extensions under this Agreement. Notwithstanding
the foregoing, Bank shall have the right to terminate its obligation to make further Credit Extensions under this Agreement immediately
and without notice upon the occurrence and during the continuance of an Event of Default.

 

3.           CONDITIONS
OF LOANS.

 

3.1         Conditions
Precedent to Closing. The agreement of Bank to enter into this Agreement on the Closing Date is subject to the condition precedent
that Bank shall have received, in form and substance satisfactory to Bank, each the following items and completed each of the following
requirements:

 

(a)          this
Agreement;

 

(b)         an
officer’s certificate of Borrower with respect to incumbency and resolutions authorizing the execution and delivery of this
Agreement;

 

(c)        
a financing statement (Form UCC-1);

 

(d)        
payment of the fees and Bank Expenses then due specified in Section 2.5, which may be debited from any of Borrower’s accounts
with Bank;

 

(e)         current
SOS Reports indicating that except for Permitted Liens, there are no other security interests or Liens of record in the Collateral;

 

(f)          current
financial statements, including statements (or such other level required by the Investment Agreement) for Borrower’s most
recently ended fiscal year, together with an unqualified opinion (or an opinion qualified only for going concern), company prepared
consolidated and consolidating balance sheets and income statements for the most recently ended month in accordance with Section
6.2, and such other updated financial information as Bank may reasonably request;

 

    	5.

    	 

    

 

(g)         current
Compliance Certificate in accordance with Section 6.2;

 

(h)         a
Warrant in form and substance satisfactory to Bank;

 

(i)          a
Borrower Information Certificate;

 

(j)          Borrower
shall have opened and funded not less than $50,000 in deposit accounts held with Bank; and

 

(k)         such
other documents or certificates, and completion of such other matters, as Bank may reasonably request.

 

3.2         Conditions
Precedent to all Credit Extensions. The obligation of Bank to make each Credit Extension, including the initial Credit Extension,
is contingent upon the Borrower’s compliance with Section 3.1 above, and is further subject to the following conditions:

 

(a)          timely
receipt by Bank of the Loan Advance/Paydown Request Form as provided in Section 2.1;

 

(b)          Borrower
shall have transferred substantially all of its Cash assets into operating accounts held with Bank and otherwise be in compliance
with Section 6.6 hereof;

 

(c)          prior
to the making of Term Loan B only, delivery of evidence to Bank that Borrower has received the New Equity in its entirety; and

 

(d)          the
representations and warranties contained in Section 5 shall be true and correct in all material respects on and as of the date
of such Loan Advance/Paydown Request Form and on the effective date of each Credit Extension as though made at and as of each
such date, and no Event of Default shall have occurred and be continuing, or would exist after giving effect to such Credit Extension
(provided, however, that those representations and warranties expressly referring to another date shall be true, correct and complete
in all material respects as of such date). The making of each Credit Extension shall be deemed to be a representation and warranty
by Borrower on the date of such Credit Extension as to the accuracy of the facts referred to in this Section 3.2.

 

4.           CREATION
OF SECURITY INTEREST.

 

4.1         Grant
of Security Interest. Borrower grants and pledges to Bank a continuing security interest in the Collateral to secure prompt
repayment of any and all Obligations and to secure prompt performance by Borrower of each of its covenants and duties under the
Loan Documents. Except for Permitted Liens or as disclosed in the Schedule, such security interest constitutes a valid, first priority
security interest in the presently existing Collateral, and will constitute a valid, first priority security interest in later-acquired
Collateral. Borrower also hereby agrees not to sell, transfer, assign, mortgage, pledge, lease, grant a security interest in, or
encumber any of its Intellectual Property. Notwithstanding any termination of this Agreement or of any filings undertaken related
to Bank’s rights under the Code, Bank’s Lien on the Collateral shall remain in effect for so long as any Obligations
are outstanding.

 

    	6.

    	 

    

4.2          Perfection
of Security Interest. Borrower authorizes Bank to file at any time financing statements, continuation statements, and amendments
thereto that (i) either specifically describe the Collateral or describe the Collateral as all assets of Borrower of the kind pledged
hereunder, and (ii) contain any other information required by the Code for the sufficiency of filing office acceptance of any financing
statement, continuation statement, or amendment, including whether Borrower is an organization, the type of organization and any
organizational identification number issued to Borrower, if applicable. Borrower shall have possession of the Collateral, except
where expressly otherwise provided in this Agreement or where Bank chooses to perfect its security interest by possession in addition
to the filing of a financing statement. Where Collateral is in possession of a third party bailee, Borrower shall take such steps
as Bank reasonably requests for Bank to (i) subject to Section 7.10 below, obtain an acknowledgment, in form and substance satisfactory
to Bank, of the bailee that the bailee holds such Collateral for the benefit of Bank, and (ii) obtain “control” of
any Collateral consisting of investment property, deposit accounts, letter-of-credit rights or electronic chattel paper (as such
items and the term “control” are defined in Revised Article 9 of the Code) by causing the securities intermediary or
depositary institution or issuing bank to execute a control agreement in form and substance satisfactory to Bank. Borrower will
not create any chattel paper without placing a legend on the chattel paper acceptable to Bank indicating that Bank has a security
interest in the chattel paper. Borrower from time to time may deposit with Bank specific cash collateral to secure specific Obligations;
Borrower authorizes Bank to hold such specific balances in pledge and to decline to honor any drafts thereon or any request by
Borrower or any other Person to pay or otherwise transfer any part of such balances for so long as the specific Obligations are
outstanding. Borrower shall take such other actions as Bank requests to perfect its security interests granted under this Agreement.

 

5.           REPRESENTATIONS
AND WARRANTIES.

 

Borrower represents and warrants
as follows:

 

5.1         Due
Organization and Qualification. Borrower and each Subsidiary is a corporation duly existing under the laws of the state in
which it is organized and qualified and licensed to do business in any state in which the conduct of its business or its ownership
of property requires that it be so qualified, except where the failure to do so would not reasonably be expected to cause a Material
Adverse Effect.

 

5.2         Due
Authorization; No Conflict. The execution, delivery, and performance of the Loan Documents are within Borrower’s powers,
have been duly authorized, and are not in conflict with nor constitute a breach of any provision contained in Borrower’s
Certificate of Incorporation or Bylaws, nor will they constitute an event of default under any material agreement by which Borrower
is bound. Borrower is not in default under any agreement by which it is bound, except to the extent such default would not reasonably
be expected to cause a Material Adverse Effect.

 

    	7.

    	 

    

5.3           Collateral.
Borrower has rights in or the power to transfer the Collateral, and its title to the Collateral is free and clear of Liens,
adverse claims, and restrictions on transfer or pledge except for Permitted Liens. Other than movable items of personal property,
for example such as laptop computers, all Collateral having an aggregate book value not in excess of $100,000, is located solely
in the Collateral States. All Inventory is in all material respects of good and merchantable quality, free from all material defects,
except for Inventory for which adequate reserves have been made. Except as set forth in the Schedule, none of the Borrower’s
Cash is maintained or invested with a Person other than Bank or Bank’s affiliates.

 

5.4           Intellectual
Property. Borrower is the sole owner of the intellectual property created or purchased by Borrower, except for licenses granted
by Borrower to its customers, strategic partners, contractors, and other third parties. To the best of Borrower’s knowledge,
each of the Copyrights, Trademarks and Patents created or purchased by Borrower is valid and enforceable, and no part of the intellectual
property created or purchased by Borrower has been judged invalid or unenforceable, in whole or in part, and, to the best of Borrower’s
knowledge, no claim has been made to Borrower that any part of the intellectual property created or purchased by Borrower violates
the rights of any third party except to the extent such claim would not reasonably be expected to cause a Material Adverse Effect.

 

5.5          Name;
Location of Chief Executive Office. Except as disclosed in the Schedule, Borrower has not done business under any name other
than that specified on the signature page hereof, and its exact legal name is as set forth in the first paragraph of this Agreement.
The chief executive office of Borrower is located at the address indicated in Section 10 hereof.

 

5.6          Litigation.
Except as set forth in the Schedule, there are no actions or proceedings pending by or against Borrower or any Subsidiary before
any court or administrative agency in which a likely adverse decision would reasonably be expected to have a Material Adverse Effect.

 

5.7          No
Material Adverse Change in Financial Statements. All consolidated and consolidating financial statements related to Borrower
and any Subsidiary that are delivered by Borrower to Bank fairly present in all material respects Borrower’s consolidated
and consolidating financial condition as of the date thereof and Borrower’s consolidated and consolidating results of operations
for the period then ended. There has not been a material adverse change in the consolidated or in the consolidating financial
condition of Borrower since the date of the most recent of such financial statements submitted to Bank.

 

5.8          Solvency,
Payment of Debts. Borrower is able to pay its debts (including trade debts) as they mature; the fair saleable value of Borrower’s
assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities; and Borrower is not left with unreasonably
small capital after the transactions contemplated by this Agreement.

 

    	8.

    	 

    

5.9         Compliance
with Laws and Regulations. Borrower and each Subsidiary have met the minimum funding requirements of ERISA with respect
to any employee benefit plans subject to ERISA. No event has occurred resulting from Borrower’s failure to comply with ERISA
that is reasonably likely to result in Borrower’s incurring any liability that could have a Material Adverse Effect. Borrower
is not an “investment company” or a company “controlled” by an “investment company” within
the meaning of the Investment Company Act of 1940. Borrower is not engaged principally, or as one of its important activities,
in the business of extending credit for the purpose of purchasing or carrying margin stock (within the meaning of Regulations
T and U of the Board of Governors of the Federal Reserve System). Borrower has not violated any statutes, laws, ordinances or
rules applicable to it, the violation of which would reasonably be expected to have a Material Adverse Effect. Borrower and each
Subsidiary have filed or caused to be filed all tax returns required to be filed, and have paid, or have made adequate provision
for the payment of, all taxes reflected therein except those being contested in good faith with adequate reserves under GAAP or
where the failure to file such returns or pay such taxes would not reasonably be expected to have a Material Adverse Effect.

 

5.10       Subsidiaries.
Borrower does not own any stock, partnership interest or other equity securities of any Person, except for Permitted Investments.

 

5.11       Government
Consents. Borrower and each Subsidiary have obtained all consents, approvals and authorizations of, made all declarations or
filings with, and given all notices to, all governmental authorities that are necessary for the continued operation of Borrower’s
business as currently conducted, except where the failure to do so would not reasonably be expected to cause a Material Adverse
Effect.

 

5.12       Inbound
Licenses. Except as disclosed on the Schedule, Borrower is not a party to, nor is bound by, any material license or other agreement
important for the conduct of Borrower’s business that prohibits or otherwise restricts Borrower from granting a security
interest in Borrower’s interest in such license or agreement or any other property important for the conduct of Borrower’s
business, other than this Agreement or the other Loan Documents.

 

5.13       Full
Disclosure. No representation, warranty or other statement made by Borrower in any certificate or written statement furnished
to Bank taken together with all such certificates and written statements furnished to Bank contains any untrue statement of a material
fact or omits to state a material fact necessary in order to make the statements contained in such certificates or statements not
misleading in light of the circumstances in which they were made, it being recognized by Bank that the projections and forecasts
provided by Borrower in good faith and based upon reasonable assumptions are not to be viewed as facts and that actual results
during the period or periods covered by any such projections and forecasts may differ from the projected or forecasted results.

 

6.           AFFIRMATIVE COVENANTS.

 

Borrower covenants that, until payment
in full of all outstanding Obligations, and for so long as Bank may have any commitment to make a Credit Extension hereunder, Borrower
shall do all of the following:

 

    	9.

    	 

    

6.1         Good
Standing and Government Compliance. Borrower shall maintain its and each of its Subsidiaries’ corporate existence
and good standing in the respective states of formation, shall maintain qualification and good standing in each other jurisdiction
in which the failure to so qualify would reasonably be expected to have a Material Adverse Effect, and shall furnish to Bank the
organizational identification number issued to Borrower by the authorities of the state in which Borrower is organized, if applicable.
Borrower shall meet, and shall cause each Subsidiary to meet, the minimum funding requirements of ERISA with respect to any employee
benefit plans subject to ERISA. Borrower shall comply, and shall cause each Subsidiary to comply, with all statutes, laws, ordinances
and government rules and regulations to which it is subject, and shall maintain, and shall cause each of its Subsidiaries to maintain,
in force all licenses, approvals and agreements, the loss of which or failure to comply with which would reasonably be expected
to have a Material Adverse Effect.

 

6.2         Financial
Statements, Reports, Certificates. Borrower shall deliver to Bank: (i) as soon as available, but in any event within
30 days after the end of each calendar month, a company prepared consolidated and consolidating balance sheet, cash flow statement
and income statement covering Borrower’s operations during such period, in a form reasonably acceptable to Bank and certified
by a Responsible Officer; (ii) as soon as available, but in any event within 180 days after the end of Borrower’s fiscal
year, audited (or such other level as is required by the Investment Agreement) consolidated and consolidating financial statements
of Borrower prepared in accordance with GAAP, consistently applied, together with an opinion on such financial statements of an
independent certified public accounting firm reasonably acceptable to Bank which is either unqualified or qualified only for going
concern, so long as in the case of the qualified opinion it is either consented to in writing by Bank or in the alternative if
following the delivery of such financial statements the Bank does not consent to such qualified Borrower’s investors will
provide additional equity as needed within 30 days after notice from the Bank of such non consent to the qualified financial statements
or otherwise; (iii) annual budget approved by Borrower’s Board of Directors as soon as available but not later than 30 days
before the beginning of the applicable calendar year, provided however, that for the 2012 annual budget only, Borrower shall provide
the 2012 annual budget approved by Borrower’s Board of Directors as soon as available but not later than March 1, 2012; (iv)
if applicable, copies of all statements, reports and notices sent or made available generally by Borrower to its security holders
or to any holders of Subordinated Debt and all reports on Forms 10-K and 10-Q filed with the Securities and Exchange Commission;
(v) promptly upon receipt of notice thereof, a report of any legal actions pending or threatened against Borrower or any Subsidiary
that could reasonably be expected to result in damages or costs to Borrower or any Subsidiary of $250,000 or more; (vi) promptly
upon receipt, each management letter prepared by Borrower’s independent certified public accounting firm regarding Borrower’s
management control systems, (vii) such budgets, sales projections, operating plans or other financial information generally prepared
by Borrower in the ordinary course of business as Bank may reasonably request from time to time.

 

(a)          Within
30 days after the last day of each month, Borrower shall deliver to Bank with the monthly financial statements a Compliance Certificate
certified as of the last day of the applicable month and signed by a Responsible Officer in substantially the form of Exhibit
D hereto.

 

(b)          As
soon as possible and in any event within three (3) Business days after becoming aware of the occurrence or existence of an Event
of Default hereunder, a written statement of a Responsible Officer setting forth details of the Event of Default, and the action
which Borrower has taken or proposes to take with respect thereto.

 

    	10.

    	 

    

 

(c)          If
an Event of Default has occurred and is continuing, Bank (through any of its officers, employees, or agents) shall have the right
to inspect Borrower’s Books and to make copies thereof and to check, test, inspect, audit and appraise the Collateral at
Borrower’s expense in order to verify Borrower’s financial condition or the amount, condition of, or any other matter
relating to, the Collateral.

 

Borrower may deliver to Bank on an electronic
basis any certificates, reports or information required pursuant to this Section 6.2, and Bank shall be entitled to rely on the
information contained in the electronic files, provided that Bank in good faith believes that the files were delivered by a Responsible
Officer. Borrower shall include a submission date on any certificates and reports to be delivered electronically.

 

6.3          Inventory
and Equipment; Returns. Borrower shall keep all Inventory and Equipment in good and merchantable condition, free from all material
defects except for Inventory and Equipment (i) sold in the ordinary course of business, and (ii) for which adequate reserves have
been made, in all cases in the United States and such other locations as to which Borrower gives prior written notice. Returns
and allowances, if any, as between Borrower and its account debtors shall be on the same basis and in accordance with the usual
customary practices of Borrower, as they exist on the Closing Date. Borrower shall promptly notify Bank of all returns and recoveries
and of all disputes and claims involving inventory having a book value of more than $100,000.

 

6.4          Taxes.
Borrower shall make, and cause each Subsidiary to make, due and timely payment or deposit of all material federal, state, and
local taxes, assessments, or contributions required of it by law, including, but not limited to, those laws concerning income taxes,
F.I.C.A., F.U.T.A. and state disability, and will execute and deliver to Bank, on demand, proof satisfactory to Bank indicating
that Borrower or a Subsidiary has made such payments or deposits and any appropriate certificates attesting to the payment or deposit
thereof; provided that Borrower or a Subsidiary need not make any payment if the amount or validity of such payment is contested
in good faith by appropriate proceedings and is reserved against (to the extent required by GAAP) by Borrower or such Subsidiary.

 

6.5         Insurance. Borrower, at its expense, shall (i) keep the Collateral insured against loss or
damage, and (ii) maintain liability and other insurance, in each case in as ordinarily insured against by other owners in
businesses similar to Borrower’s. All such policies of insurance shall be in such form, with such companies, and in
such amounts as reasonably satisfactory to Bank. All policies of property insurance shall contain a lender’s loss
payable endorsement, in a form satisfactory to Bank, showing Bank as an additional loss payee, and all liability insurance
policies shall show Bank as an additional insured and specify that the insurer must give at least 10 days notice to Bank
before canceling its policy for any reason. Within 30 days of the Closing Date, Borrower shall cause to be furnished to Bank
a copy of its policies or certificate of insurance including any endorsements covering Bank or showing Bank as an additional
insured. Upon Bank’s request, Borrower shall deliver to Bank certified copies of the policies of insurance and evidence
of all premium payments. Proceeds payable under any casualty policy covering the Collateral will, at Borrower’s option,
be payable to Borrower to replace the property subject to the claim, provided that any such replacement property shall be
deemed Collateral in which Bank has been granted a first priority security interest, provided that if an Event of Default has
occurred and is continuing, all proceeds payable under any such policy shall, at Bank’s option, be payable to Bank to
be applied on account of the Obligations.

 

    	11.

    	 

    

 

6.6          “Primary
Depository”. Subject to the provisions of Section 3.1(j) and 3.2(b), Borrower within 30 days of the Closing Date shall
maintain all its depository and operating accounts with Bank and its primary investment accounts with Bank or Bank’s affiliates.

 

6.7          Financial
Covenants. Borrower shall at all times maintain at least one of the following financial ratios and covenants:

 

(a)          Liquidity
Ratio. A Liquidity Ratio of at least 1.25 to 1.00; or

 

(b)          Cash
Burn. Tested monthly and calculated on a trailing six-months average, a Cash Burn of not more than the amounts shown in column
B below for the corresponding reporting period in column A.

 

	A	 	B	 
	Reporting Period Ending On	 	Maximum Cash Burn	 
	August 31, 2011	 	$	1,720,400	 
	September 30, 2011	 	$	1,897,700	 
	October 31, 2011	 	$	2,123,300	 
	November 30, 2011	 	$	2,457,900	 
	December 31, 2011	 	$	1,907,600	 
	January 31, 2012	 	$	1,935,400	 
	February 29, 2012	 	$	1,884,900	 
	March 31, 2012	 	$	1,651,000	 
	April 30, 2012	 	$	1,699,300	 
	May 31, 2012	 	$	1,658,900	 
	June 30, 2012	 	$	1,584,100	 
	July 31, 2012	 	$	1,288,200	 
	August 31, 2012	 	$	1,288,800	 
	September 30, 2012	 	$	1,190,100	 
	October 31, 2012	 	$	1,149,500	 
	November 30, 2012	 	$	1,139,600	 
	December 31, 2012	 	$	1,006,200	 

 

Beginning with December 1, 2012,
Bank and Borrower hereby agree that, on or before December 1st of each year during the term of this Agreement, Borrower shall
provide to Bank a fully-funded budget for the upcoming calendar year, and Bank shall use that budget to establish the maximum
Cash Burn amounts for the upcoming year, with such maximum amounts being incorporated herein by an amendment, which shall be
promptly executed by Bank and Borrower.

 

    	12.

    	 

    

 

6.8           Notice
of Inbound Licensors. Prior to entering into or becoming bound by any material inbound license or agreement, Borrower shall
provide written notice to Bank of the material terms of such license or agreement with a description of its likely impact on Borrower’s
business or financial condition. .

 

6.9           Further
Assurances. At any time and from time to time Borrower shall execute and deliver such further instruments and take such further
action as may reasonably be requested by Bank to effect the purposes of this Agreement.

 

7.           NEGATIVE
COVENANTS.

 

Borrower covenants and agrees that, so
long as any credit hereunder shall be available and until the outstanding Obligations are paid in full or for so long as Bank may
have any commitment to make any Credit Extensions, Borrower will not do any of the following without Bank’s prior written
consent, which shall not be unreasonably withheld:

 

7.1           Dispositions.
Convey, sell, lease, license, transfer or otherwise dispose of (collectively, to “Transfer”), or permit any of
its Subsidiaries to Transfer, all or any part of its business or property, or move cash balances on deposit with Bank to accounts
opened at another financial institution, other than Permitted Transfers.

 

7.2           Change
in Name, Location, Executive Office, or Executive Management; Change in Business; Change in Fiscal Year; Change in Control. Change
its name or the state of Borrower’s incorporation or relocate its chief executive office without 30 days prior written notification
to Bank; replace or suffer the departure of its chief executive officer or chief financial officer without delivering written notification
to Bank within 10 days following such event; fail to appoint an interim replacement or fill a vacancy in the position of chief
executive officer or chief financial officer for more than 30 consecutive days; suffer a change on its board of directors which
results in the failure of at least one partner of Harris & Harris Group or its Affiliates to serve as a voting member, or suffer
the resignation of one or more directors from its board of directors in anticipation of the Company’s insolvency, in either
case without the prior written consent of Bank which may be withheld in Bank’s sole discretion; take action to liquidate, wind
up, or otherwise cease to conduct business in the ordinary course; engage in any business, or permit any of its Subsidiaries to
engage in any business, other than or reasonably related or incidental to the businesses currently engaged in by Borrower; change
its fiscal year end; have a Change in Control.

 

    	13.

    	 

    

 

7.3           Mergers
or Acquisitions. Merge or consolidate, or permit any of its Subsidiaries to merge or consolidate, with or into any other business
organization (other than mergers or consolidations of a Subsidiary into another Subsidiary or into Borrower), or acquire, or permit
any of its Subsidiaries to acquire, all or substantially all of the capital stock or property of another Person except where (a)
each of the following conditions is applicable: (i) the consideration paid in connection with such transactions (including assumption
of liabilities) does not in the aggregate exceed $250,000 during any fiscal year, (ii) no Event of Default has occurred and is
continuing or would exist after giving effect to such transactions, (iii) such transactions do not result in a Change in Control,
and (iv) Borrower is the surviving entity; or (b) the Obligations are repaid in full concurrently with the closing of any merger
or consolidation of Borrower in which Borrower is not the surviving entity; provided, however, that Borrower shall not, without
Bank’s prior written consent, enter into any binding contractual arrangement with any Person to facilitate a merger or acquisition
of Borrower; provided however, Borrower may enter into any such agreement without Bank’s prior written consent so long as (i) no
Event of Default exists when such agreement is entered into by Borrower, (ii) such agreement does not give such Person the right
to claim any fee, payment or damages from any parties, other than from Borrower or Borrower’s investors, in connection with a sale
of Borrower’s stock or assets pursuant to or resulting from an assignment for the benefit of creditors, an asset turnover to Borrower’s
creditors (including, without limitation, Bank), foreclosure, bankruptcy or similar liquidation, and (iii) Borrower notifies Bank
in advance of entering into such an agreement (provided, the failure to give such notification shall not be deemed a material breach
of this Agreement).

 

7.4           Indebtedness.
Create, incur, assume, guarantee or be or remain liable with respect to any Indebtedness, or permit any Subsidiary so to do, other
than Permitted Indebtedness, or prepay any Indebtedness or take any actions which impose on Borrower an obligation to prepay any
Indebtedness, except Indebtedness to Bank.

 

7.5           Encumbrances.
Create, incur, assume or allow any Lien with respect to its property, or assign or otherwise convey any right to receive income,
including the sale of any Accounts, or permit any of its Subsidiaries so to do, except for Permitted Liens, or covenant to any
other Person (other than (i) the licensors of in-licensed property with respect to such property or (ii) the lessors of specific
equipment or lenders financing specific equipment with respect to such leased or financed equipment) that Borrower in the future
will refrain from creating, incurring, assuming or allowing any Lien with respect to any of Borrower’s property.

 

7.6           Distributions.
Pay any dividends or make any other distribution or payment on account of or in redemption, retirement or purchase of any capital
stock, except that Borrower may (i) repurchase the stock of former employees or consultants pursuant to stock repurchase agreements
as long as an Event of Default does not exist prior to such repurchase or would not exist after giving effect to such repurchase,
and (ii) repurchase the stock of former employees or consultants pursuant to stock repurchase agreements by the cancellation of
indebtedness owed by such former employees or consultants to Borrower regardless of whether an Event of Default exists.

 

7.7           Investments.
Directly or indirectly acquire or own, or make any Investment in or to any Person, or permit any of its Subsidiaries so to do,
other than Permitted Investments, or maintain or invest any of its Investment Property with a Person other than Bank or Bank’s
Affiliates or permit any Subsidiary to do so unless such Person has entered into a control agreement with Bank, in form and substance
satisfactory to Bank, or suffer or permit any Subsidiary to be a party to, or be bound by, an agreement that restricts such Subsidiary
from paying dividends or otherwise distributing property to Borrower.

 

    	14.

    	 

    

 

7.8          Transactions
with Affiliates. Directly or indirectly enter into or permit to exist any material transaction with any Affiliate of Borrower
except for transactions that are in the ordinary course of Borrower’s business, upon fair and reasonable terms that are
no less favorable to Borrower than would be obtained in an arm’s length transaction with a non-affiliated Person.

 

7.9          Subordinated
Debt. Make any payment in respect of any Subordinated Debt, or permit any of its Subsidiaries to make any such payment, except
in compliance with the terms of such Subordinated Debt, or amend any provision affecting Bank’s rights contained in any documentation
relating to the Subordinated Debt without Bank’s prior written consent.

 

7.10        Inventory
and Equipment. Store the Inventory or the Equipment of a book value in excess of $100,000 with a bailee, warehouseman, collocation
facility or similar third party unless the third party has been notified of Bank’s security interest and Bank (a) has received
an acknowledgment from the third party that it is holding or will hold the Inventory or Equipment for Bank’s benefit or (b)
is in possession of the warehouse receipt, where negotiable, covering such Inventory or Equipment. Except for Inventory sold in
the ordinary course of business and for movable items of personal property having an aggregate book value not in excess of $100,000,
and except for such other locations as Bank may approve in writing, Borrower shall keep the Inventory and Equipment only at the
location set forth in Section 10 and such other locations of which Borrower gives Bank prior written notice and as to which Bank
is able to take such actions as may be necessary to perfect its security interest or to obtain a bailee’s acknowledgment
of Bank’s rights in the Collateral.

 

7.11        No
Investment Company; Margin Regulation. Become or be controlled by an “investment company,” within the meaning of
the Investment Company Act of 1940, or become principally engaged in, or undertake as one of its important activities, the business
of extending credit for the purpose of purchasing or carrying margin stock, or use the proceeds of any Credit Extension for such
purpose.

 

8.           EVENTS
OF DEFAULT.

 

Any one or more
of the following events shall constitute an Event of Default by Borrower under this Agreement:

 

8.1          Payment
Default. If Borrower fails to pay any of the Obligations when due;

 

8.2          Covenant
Default.

 

(a)          If
Borrower fails to perform any obligation under Sections 6.2 (financial reporting), 6.4 (taxes), 6.5 (insurance), 6.6 (primary
accounts) or 6.7 (financial covenants), or violates any of the covenants contained in Article 7 of this Agreement; or

 

    	15.

    	 

    

 

(b)          If
Borrower fails or neglects to perform or observe any other material term, provision, condition, covenant contained in this Agreement,
in any of the Loan Documents, or in any other present or future agreement between Borrower and Bank and as to any default under
such other term, provision, condition or covenant that can be cured, has failed to cure such default within fifteen (15) days
after Borrower receives notice thereof or the Chief Executive Office or Chief Financial Officer of Borrower has actual knowledge
thereof; provided, however, that if the default cannot by its nature be cured within the fifteen (15) day period or cannot after
diligent attempts by Borrower be cured within such fifteen (15) day period, and such default is likely to be cured within a reasonable
time, then Borrower shall have an additional reasonable period (which shall not in any case exceed forty-five (45) days) to attempt
to cure such default, and within such reasonable time period the failure to have cured such default shall not be deemed an Event
of Default but no Credit Extensions will be made.

 

8.3          Material
Adverse Change. If there occurs any circumstance or any circumstances which would reasonably be expected to have a Material
Adverse Effect;

 

8.4          Attachment.
If any material portion of Borrower’s assets is attached, seized, subjected to a writ or distress warrant, or is levied
upon, or comes into the possession of any trustee, receiver or person acting in a similar capacity and such attachment, seizure,
writ or distress warrant or levy has not been removed, discharged or rescinded within 10 days, or if Borrower is enjoined, restrained,
or in any way prevented by court order from continuing to conduct all or any material part of its business affairs, or if a judgment
or other claim becomes a lien or encumbrance upon any material portion of Borrower’s assets, or if a notice of lien, levy,
or assessment is filed of record with respect to any material portion of Borrower’s assets by the United States Government,
or any department, agency, or instrumentality thereof, or by any state, county, municipal, or governmental agency, and the same
is not paid within ten days after Borrower receives notice thereof, provided that none of the foregoing shall constitute an Event
of Default where such action or event is stayed or an adequate bond has been posted pending a good faith contest by Borrower (provided
that no Credit Extensions will be made during such cure period);

 

8.5          Insolvency.
If Borrower becomes insolvent, or if an Insolvency Proceeding is commenced by Borrower, or if an Insolvency Proceeding is commenced
against Borrower and is not dismissed or stayed within 45 days (provided that no Credit Extensions will be made prior to the dismissal
of such Insolvency Proceeding);

 

8.6          Other
Agreements. If there is a default by the Borrower in any agreement to which Borrower is a party with a third party or parties
resulting in a right by such third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in
an amount in excess of $250,000 or that would reasonably be expected to have a Material Adverse Effect;

 

8.7          Judgments.
If a final, uninsured judgment or judgments for the payment of money in an amount, individually or in the aggregate, of at
least $250,000 shall be rendered against Borrower and shall remain unsatisfied and unstayed for a period of 10 days (provided that
no Credit Extensions will be made prior to the satisfaction or stay of the judgment); or

 

8.8          Misrepresentations.
If any material misrepresentation or material misstatement exists as of the date made in any warranty or representation set
forth herein or in any certificate delivered to Bank by any Responsible Officer pursuant to this Agreement or to induce Bank to
enter into this Agreement or any other Loan Document.

 

    	16.

    	 

    

  

9.           BANK’S
RIGHTS AND REMEDIES.

 

9.1          Rights
and Remedies. Upon the occurrence and during the continuance of an Event of Default, Bank may, at its election, without notice
of its election and without demand, do any one or more of the following, all of which are authorized by Borrower:

 

(a)          Declare
all Obligations, whether evidenced by this Agreement, by any of the other Loan Documents, or otherwise, immediately due and payable
(provided that upon the occurrence of an Event of Default described in Section 8.5 (insolvency), all Obligations shall become
immediately due and payable without any action by Bank);

 

(b)          Demand
that Borrower (i) deposit cash with Bank in an amount equal to the amount of any Letters of Credit remaining undrawn, as collateral
security for the repayment of any future drawings under such Letters of Credit, and (ii) pay in advance all Letter of Credit fees
scheduled to be paid or payable over the remaining term of the Letters of Credit, and Borrower shall promptly deposit and pay
such amounts;

 

(c)          Cease
advancing money or extending credit to or for the benefit of Borrower under this Agreement or under any other agreement between
Borrower and Bank;

 

(d)          Settle
or adjust disputes and claims directly with account debtors for amounts, upon terms and in whatever order that Bank reasonably
considers advisable;

 

(e)          Make
such payments and do such acts as Bank considers necessary or reasonable to protect its security interest in the Collateral. Borrower
agrees to assemble the Collateral if Bank so requires, and to make the Collateral available to Bank as Bank may designate. Borrower
authorizes Bank to enter the premises where the Collateral is located, to take and maintain possession of the Collateral, or any
part of it, and to pay, purchase, contest, or compromise any encumbrance, charge, or lien which in Bank’s determination
appears to be prior or superior to its security interest and to pay all expenses incurred in connection therewith. With respect
to any of Borrower’s owned premises, Borrower hereby grants Bank a license to enter into possession of such premises and
to occupy the same, without charge, in order to exercise any of Bank’s rights or remedies provided herein, at law, in equity,
or otherwise;

 

(f)          Set
off and apply to the Obligations any and all (i) balances and deposits of Borrower held by Bank, and (ii) indebtedness at any
time owing to or for the credit or the account of Borrower held by Bank;

 

(g)          Ship,
reclaim, recover, store, finish, maintain, repair, prepare for sale, advertise for sale, and sell (in the manner provided for
herein) the Collateral. Bank is hereby granted a license or other right, to the extent it may be granted, solely pursuant to the
provisions of this Section 9.1, to use, without charge, Borrower’s labels, patents, copyrights, rights of use of any name,
trade secrets, trade names, trademarks, service marks, and advertising matter, or any property of a similar nature, to complete
production of, advertise for sale, and sell any Collateral and, in connection with Bank’s exercise of its rights under this
Section 9.1, Borrower’s rights under all licenses which are included in the Collateral and all franchise agreements shall
inure to Bank’s benefit;

 

    	17.

    	 

    

  

(h)          Sell
the Collateral at either a public or private sale, or both, by way of one or more contracts or transactions, for cash or on terms,
in such manner and at such places (including Borrower’s premises) as Bank determines is commercially reasonable, and apply
any proceeds to the Obligations in whatever manner or order Bank deems appropriate. Bank may sell the Collateral without giving
any warranties as to the Collateral. Bank may specifically disclaim any warranties of title or the like. This procedure will not
be considered adversely to affect the commercial reasonableness of any sale of the Collateral. If Bank sells any of the Collateral
upon credit, Borrower will be credited only with payments actually made by the purchaser, received by Bank, and applied to the
indebtedness of the purchaser. If the purchaser fails to pay for the Collateral, Bank may resell the Collateral and Borrower shall
be credited with the proceeds of the sale;

 

(i)          Bank
may credit bid and purchase at any public sale;

 

(j)          Apply
for the appointment of a receiver, trustee, liquidator or conservator of the Collateral, without notice and without regard to
the adequacy of the security for the Obligations and without regard to the solvency of Borrower, any guarantor or any other Person
liable for any of the Obligations; and

 

(k)          Any
deficiency that exists after disposition of the Collateral as provided above will be paid immediately by Borrower.

 

Bank may comply
with any applicable state or federal law requirements in connection with a disposition of the Collateral and compliance will not
be considered adversely to affect the commercial reasonableness of any sale of the Collateral.

 

9.2          Power
of Attorney. Effective only upon the occurrence and during the continuance of an Event of Default, Borrower hereby irrevocably
appoints Bank (and any of Bank’s designated officers, or employees) as Borrower’s true and lawful attorney to: (a)
send requests for verification of Accounts or notify account debtors of Bank’s security interest in the Accounts; (b) endorse
Borrower’s name on any checks or other forms of payment or security that may come into Bank’s possession; (c) sign
Borrower’s name on any invoice or bill of lading relating to any Account, drafts against account debtors, schedules and assignments
of Accounts, verifications of Accounts, and notices to account debtors; (d) dispose of any Collateral; (e) make, settle, and adjust
all claims under and decisions with respect to Borrower’s policies of insurance; (f) settle and adjust disputes and claims
respecting the accounts directly with account debtors, for amounts and upon terms which Bank determines to be reasonable; and (g)
file, in its sole discretion, one or more financing or continuation statements and amendments thereto, relative to any of the Collateral;
provided Bank may exercise such power of attorney to sign the name of Borrower on any of the documents described in clause (g)
above, regardless of whether an Event of Default has occurred. The appointment of Bank as Borrower’s attorney in fact, and
each and every one of Bank’s rights and powers, being coupled with an interest, is irrevocable until all of the Obligations
have been fully repaid and performed and Bank’s obligation to provide advances hereunder is terminated.

 

    	18.

    	 

    

 

9.3           Accounts
Collection. At any time after the occurrence and during the continuation of an Event of Default, Bank may notify any Person
owing funds to Borrower of Bank’s security interest in such funds and verify the amount of such Account. Borrower shall collect
all amounts owing to Borrower for Bank, receive in trust all payments as Bank’s trustee, and immediately deliver such payments
to Bank in their original form as received from the account debtor, with proper endorsements for deposit.

 

9.4           Bank
Expenses. If Borrower fails to pay any amounts or furnish any required proof of payment due to third persons or entities, as
required under the terms of this Agreement, then Bank may do any or all of the following after reasonable notice to Borrower: (a)
make payment of the same or any part thereof; and/or (b) obtain and maintain insurance policies of the type discussed in Section
6.5 of this Agreement, and take any action with respect to such policies as Bank deems prudent. Any amounts so paid or deposited
by Bank shall constitute Bank Expenses, shall be immediately due and payable, and shall bear interest at the then applicable rate
hereinabove provided, and shall be secured by the Collateral. Any payments made by Bank shall not constitute an agreement by Bank
to make similar payments in the future or a waiver by Bank of any Event of Default under this Agreement.

 

9.5           Bank’s
Liability for Collateral. Bank has no obligation to clean up or otherwise prepare the Collateral for sale. All risk of loss,
damage or destruction of the Collateral shall be borne by Borrower.

 

9.6           No
Obligation to Pursue Others. Bank has no obligation to attempt to satisfy the Obligations by collecting them from any other
person liable for them and Bank may release, modify or waive any collateral provided by any other Person to secure any of the Obligations,
all without affecting Bank’s rights against Borrower. Borrower waives any right it may have to require Bank to pursue any
other Person for any of the Obligations.

 

9.7           Remedies
Cumulative. Bank’s rights and remedies under this Agreement, the Loan Documents, and all other agreements shall be cumulative.
Bank shall have all other rights and remedies not inconsistent herewith as provided under the Code, by law, or in equity. No exercise
by Bank of one right or remedy shall be deemed an election, and no waiver by Bank of any Event of Default on Borrower’s part
shall be deemed a continuing waiver. No delay by Bank shall constitute a waiver, election, or acquiescence by it. No waiver by
Bank shall be effective unless made in a written document signed on behalf of Bank and then shall be effective only in the specific
instance and for the specific purpose for which it was given. Borrower expressly agrees that this Section 9.7 may not be waived
or modified by Bank by course of performance, conduct, estoppel or otherwise.

 

9.8           Demand;
Protest. Except as otherwise provided in this Agreement, Borrower waives demand, protest, notice of protest, notice of default
or dishonor, notice of payment and nonpayment and any other notices relating to the Obligations.

 

    	19.

    	 

    

 

10.         NOTICES.

 

Unless otherwise provided in this Agreement,
all notices or demands by any party relating to this Agreement or any other agreement entered into in connection herewith shall
be in writing and (except for financial statements and other informational documents which may be sent by first-class mail, postage
prepaid) shall be personally delivered or sent by a recognized overnight delivery service, certified mail, postage prepaid, return
receipt requested, or by telefacsimile to Borrower or to Bank, as the case may be, at its addresses set forth below:

 

	If to Borrower:	Enumeral Biomedical Corp.
	 	1450 Broadway
	 	New York, NY 10018

 

	 	Attn:	 	 
	 	FAX:	 	 

 

	If to Bank:	Square 1 Bank
	 	406 Blackwell Street, Suite 240 
	 	Durham, North Carolina 27701 
	 	Attn: Loan Operations Manager 
	 	FAX: (919) 314-3080

 

	with a copy to:	Square 1 Bank
	 	424 Madison Avenue, Sixth Floor 
	 	New York, NY 10017
	 	 
	 	Attn: Bill Stickle 
	 	FAX: (646)336-4961

 

The parties hereto may change the address
at which they are to receive notices hereunder, by notice in writing in the foregoing manner given to the other.

 

    	20.

    	 

    

  

11.        CHOICE
OF LAW AND VENUE; JURY TRIAL WAIVER.

 

This Agreement shall be governed by,
and construed in accordance with, the internal laws of the State of North Carolina, without regard to principles of conflicts of
law. Jurisdiction shall lie in the State of North Carolina. All disputes, controversies, claims, actions and similar proceedings
arising with respect to Borrower’s account or any related agreement or transaction shall be brought in the General Court
of Justice of North Carolina sitting in Durham County, North Carolina or the United States District Court for the Middle District
of North Carolina, except as provided below with respect to arbitration of such matters. BANK AND BORROWER EACH ACKNOWLEDGE THAT
THE RIGHT TO TRIAL BY JURY IS A CONSTITUTIONAL ONE, BUT THAT IT MAY BE WAIVED. EACH OF THEM, AFTER CONSULTING OR HAVING HAD THE
OPPORTUNITY TO CONSULT, WITH COUNSEL OF THEIR CHOICE, KNOWINGLY, VOLUNTARILY AND INTENTIONALLY WAIVES ANY RIGHT ANY OF THEM MAY
HAVE TO A TRIAL BY JURY IN ANY LITIGATION BASED UPON OR ARISING OUT OF THIS AGREEMENT OR ANY RELATED INSTRUMENT OR LOAN DOCUMENT
OR ANY OF THE TRANSACTIONS CONTEMPLATED BY THIS AGREEMENT OR ANY COURSE OF CONDUCT, DEALING, STATEMENTS (WHETHER ORAL OR WRITTEN),
OR ACTION OF ANY OF THEM. THESE PROVISIONS SHALL NOT BE DEEMED TO HAVE BEEN MODIFIED IN ANY RESPECT OR RELINQUISHED BY BANK OR
BORROWER, EXCEPT BY A WRITTEN INSTRUMENT EXECUTED BY EACH OF THEM. If the jury waiver set forth in this Section 11 is not enforceable,
then any dispute, controversy, claim, action or similar proceeding arising out of or relating to this Agreement, the Loan Documents
or any of the transactions contemplated therein shall be settled by final and binding arbitration held in Durham County, North
Carolina in accordance with the then current Commercial Arbitration Rules of the American Arbitration Association by one arbitrator
appointed in accordance with those rules. The arbitrator shall apply North Carolina law to the resolution of any dispute, without
reference to rules of conflicts of law or rules of statutory arbitration. Judgment upon any award resulting from arbitration may
be entered into and enforced by any state or federal court having jurisdiction thereof. Notwithstanding the foregoing, the parties
may apply to any court of competent jurisdiction for preliminary or interim equitable relief, or to compel arbitration in accordance
with this Section. The costs and expenses of the arbitration, including without limitation, the arbitrator’s fees and expert
witness fees, and reasonable attorneys’ fees, incurred by the parties to the arbitration may be awarded to the prevailing
party, in the discretion of the arbitrator, or may be apportioned between the parties in any manner deemed appropriate by the arbitrator.
Unless and until the arbitrator decides that one party is to pay for all (or a share) of such costs and expenses, both parties
shall share equally in the payment of the arbitrator’s fees as and when billed by the arbitrator.

 

12.         GENERAL
PROVISIONS.

 

12.1         Successors
and Assigns. This Agreement shall bind and inure to the benefit of the respective successors and permitted assigns of each
of the parties and shall bind all persons who become bound as a debtor to this Agreement; provided, however, that neither this
Agreement nor any rights hereunder may be assigned by Borrower without Bank’s prior written consent, which consent may be
granted or withheld in Bank’s sole discretion. Bank shall have the right without the consent of or notice to Borrower to
sell, assign, transfer, negotiate, or grant participation in all or any part of, or any interest in, Bank’s obligations,
rights and benefits hereunder.

 

12.2         Indemnification.
Borrower shall defend, indemnify and hold harmless Bank and its officers, employees, and agents against: (a) all obligations,
demands, claims, and liabilities claimed or asserted by any other party in connection with the transactions contemplated by this
Agreement; and (b) all losses or Bank Expenses in any way suffered, incurred, or paid by Bank, its officers, employees and agents
as a result of or in any way arising out of, following, or consequential to transactions between Bank and Borrower whether under
this Agreement, or otherwise (including without limitation reasonable attorneys fees and expenses), except for losses caused by
Bank’s gross negligence or willful misconduct.

 

12.3         Time
of Essence. Time is of the essence for the performance of all obligations set forth in this Agreement.

 

    	21.

    	 

    

  

12.4         Severability
of Provisions. Each provision of this Agreement shall be severable from every other provision of this Agreement for the purpose
of determining the legal enforceability of any specific provision.

 

12.5         Amendments
in Writing, Integration. All amendments to or terminations of this Agreement or the other Loan Documents must be in
writing. All prior agreements, understandings, representations, warranties, and negotiations between the parties hereto with respect
to the subject matter of this Agreement and the other Loan Documents, if any, are merged into this Agreement and the Loan Documents.

 

12.26         Counterparts.
This Agreement may be executed in any number of counterparts and by different parties on separate counterparts, each of which,
when executed and delivered, shall be deemed to be an original, and all of which, when taken together, shall constitute but one
and the same Agreement. Executed copies of the signature pages of this Agreement sent by facsimile or transmitted electronically
in Portable Document Format (“PDF”), or any similar format, shall be treated as originals, fully binding and with full
legal force and effect, and the parties waive any rights they may have to object to such treatment.

 

12.7         Survival.
All covenants, representations and warranties made in this Agreement shall continue in full force and effect so long as any
Obligations remain outstanding or Bank has any obligation to make any Credit Extension to Borrower. The obligations of Borrower
to indemnify Bank with respect to the expenses, damages, losses, costs and liabilities described in Section 12.2 shall survive
until all applicable statute of limitations periods with respect to actions that may be brought against Bank have run.

 

12.8         Confidentiality.
In handling any confidential information, Bank and all employees and agents of Bank shall exercise the same degree of care
that Bank exercises with respect to its own proprietary information of the same types to maintain the confidentiality of any non-public
information thereby received or received pursuant to this Agreement except that disclosure of such information may be made (i)
to the subsidiaries or Affiliates of Bank or Borrower in connection with their present or prospective business relations with Borrower,
(ii) to prospective transferees or purchasers of any interest in the Credit Extensions, provided that they have entered into a
comparable confidentiality agreement in favor of Borrower and have delivered a copy to Borrower, (iii) as required by law, regulations,
rule or order, subpoena, judicial order or similar order, (iv) as may be required in connection with the examination, audit or
similar investigation of Bank and (v) as Bank may determine in connection with the enforcement of any remedies hereunder. Confidential
information hereunder shall not include information that either: (a) is in the public domain or in the knowledge or possession
of Bank when disclosed to Bank, or becomes part of the public domain after disclosure to Bank through no fault of Bank; or (b)
is disclosed to Bank by a third party, provided Bank does not have actual knowledge that such third party is prohibited from disclosing
such information.

 

********

 

    	22.

    	 

    

 

IN WITNESS WHEREOF, the parties hereto have caused this Agreement
to be executed as of the date first above written.

 

	 	ENUMERAL BIOMEDICAL CORP.
	 	 	 
	 	By:	/s/ John J. Rydzewsk
	 	 	 
	 	Title:	Executive Chairman
	 	 	 
	 	SQUARE 1 BANK
	 	 	 
	 	By:	/s/ Basil Kushuir
	 	 	 
	 	Title:	AVP

 

    	23.

    	 

    

 

EXHIBIT A

 

DEFINITIONS

 

“Accounts” means all presently
existing and hereafter arising accounts, contract rights, payment intangibles and all other forms of obligations owing to Borrower
arising out of the sale or lease of goods (including, without limitation, the licensing of software and other technology) or the
rendering of services by Borrower and any and all credit insurance, guaranties, and other security therefore, as well as all merchandise
returned to or reclaimed by Borrower and Borrower’s Books relating to any of the foregoing.

 

“Affiliate” means, with
respect to any Person, any Person that owns or controls directly or indirectly such Person, any Person that controls or is controlled
by or is under common control with such Person, and each of such Person’s senior executive officers, directors, and general
partners.

 

“Authorized Officer” means
someone designated as such in the corporate resolution provided by Borrower to Bank in which this Agreement and the transactions
contemplated hereunder are authorized by Borrower’s board of directors. If Borrower provides subsequent corporate resolutions
to Bank after the Closing Date, the individual(s) designated as “Authorized Officer(s)” in the most-recently provided
resolution shall be the only “Authorized Officers” for purposes of this Agreement.

 

“Bank Expenses” means all
reasonable costs or expenses (including reasonable attorneys’ fees and expenses) incurred in connection with the preparation,
negotiation, administration, and enforcement of the Loan Documents; reasonable Collateral audit fees; and Bank’s reasonable
attorneys’ fees and expenses (whether generated in-house or by outside counsel) incurred in amending, enforcing or defending
the Loan Documents (including fees and expenses of appeal), incurred before, during and after an Insolvency Proceeding, whether
or not suit is brought.

 

“Borrower’s
Books” means all of Borrower’s books and records including: ledgers; records concerning Borrower’s assets
or liabilities, the Collateral, business operations or financial condition; and all computer programs, or tape files, and the
equipment, containing such information.

 

“Business Day” means any
day that is not a Saturday, Sunday, or other day on which banks in the State of North Carolina are authorized or required to close.

 

“Cash” means unrestricted
cash and cash equivalents.

 

“Cash Bum” means an amount
equal to the prior period’s Cash minus the current period’s ending Cash that has been adjusted for any changes to Cash
as a result of borrowings and repayments of borrowings, proceeds from the sale of equity for Cash and the exercise of stock options
or warrants for Cash, paid-in-capital and minority interest, and capital expenditures financed under a capital lease.

 

“Change in Control” shall
mean a transaction other than a bona fide equity financing or series of financings on terms and from investors reasonably acceptable
to Bank in which any “person” or “group” (within the meaning of Section 13(d) and 14(d)(2) of the Securities
Exchange Act of 1934) becomes the “beneficial owner” (as defined in Rule 13d-3 under the Securities Exchange Act of
1934), directly or indirectly, of a sufficient number of shares of all classes of stock then outstanding of Borrower ordinarily
entitled to vote in the election of directors, empowering such “person” or “group” to elect a majority
of the Board of Directors of Borrower, who did not have such power before such transaction.

 

    	1.

    	 

    

 

“Closing Date” means the
date of this Agreement.

 

“Code” means the North Carolina
Uniform Commercial Code as amended or supplemented from time to time.

 

“Collateral” means the property
described on Exhibit B attached hereto and all Negotiable Collateral to the extent not described on Exhibit B, except to the extent
any such property (i) is nonassignable by its terms without the consent of the licensor thereof or another party (but only to the
extent such prohibition on transfer is enforceable under applicable law, including, without limitation, §25-9-406 and §25-9-408
of the Code), (ii) the granting of a security interest therein is contrary to applicable law, provided that upon the cessation
of any such restriction or prohibition, such property shall automatically become part of the Collateral, (iii) constitutes the
capital stock of a controlled foreign corporation (as defined in the IRC), in excess of 65% of the voting power of all classes
of capital stock of such controlled foreign corporations entitled to vote, or (iv) property (including any attachments, accessions
or replacements) that is subject to a Lien that is permitted pursuant to clause (c) of the definition of Permitted Liens, if the
grant of a security interest with respect to such property pursuant to this Agreement would be prohibited by the agreement creating
such Permitted Lien or would otherwise constitute a default thereunder, provided, that such property will be deemed “Collateral”
hereunder upon the termination and release of such Permitted Lien.

 

“Collateral State” means
the state or states where the Collateral is located, which is New York and Massachusetts.

 

“Contingent Obligation”
means, as applied to any Person, any direct or indirect liability, contingent or otherwise, of that Person with respect to (i)
any indebtedness, lease, dividend, letter of credit or other obligation of another, including, without limitation, any such obligation
directly or indirectly guaranteed, endorsed, comade or discounted or sold with recourse by that Person, or in respect of which
that Person is otherwise directly or indirectly liable; (ii) any obligations with respect to undrawn letters of credit, corporate
credit cards or merchant services issued for the account of that Person; and (iii) all obligations arising under any interest rate,
currency or commodity swap agreement, interest rate cap agreement, interest rate collar agreement, or other agreement or arrangement
designated to protect a Person against fluctuation in interest rates, currency exchange rates or commodity prices; provided, however,
that the term “Contingent Obligation” shall not include endorsements for collection or deposit in the ordinary course
of business. The amount of any Contingent Obligation shall be deemed to be an amount equal to the stated or determined amount of
the primary obligation in respect of which such Contingent Obligation is made or, if not stated or determinable, the maximum reasonably
anticipated liability in respect thereof as determined by such Person in good faith; provided, however, that such amount shall
not in any event exceed the maximum amount of the obligations under the guarantee or other support arrangement.

 

“Copyrights” means any and
all copyright rights, copyright applications, copyright registrations and like protections in each work or authorship and derivative
work thereof, whether published or unpublished and whether or not the same also constitutes a trade secret, now or hereafter existing,
created, acquired or held.

 

“Credit Extension” means
each Term Loan, Equipment Advance, or any other extension of credit, by Bank to or for the benefit of Borrower hereunder.

 

“Equipment” means all present
and future machinery, equipment, tenant improvements, furniture, fixtures, vehicles, tools, parts and attachments in which Borrower
has any interest.

 

“Equipment Advance(s)” means
a cash advance or cash advances under the Equipment Loan.

 

    	2.

    	 

    

  

“Equipment Availability End Date”
means July 31, 2012.

 

“Equipment Interest-Only End Date”
means, for each Equipment Advance, the date that is 6 months after the date upon which that particular Equipment Advance is made.

 

“Equipment Loan” means a
Credit Extension of up to $790,000.

 

“Equipment Maturity Date”
means, for each Equipment Advance, the date that is 36 months after the date upon which that particular Equipment Advance is made.

 

“ERISA” means the Employee
Retirement Income Security Act of 1974, as amended, and the regulations thereunder.

 

“Event of Default” has the
meaning assigned in Article 8.

 

“GAAP” means generally accepted
accounting principles, consistently applied, as in effect from time to time in the United States.

 

“Indebtedness” means (a)
all indebtedness for borrowed money or the deferred purchase price of property or services, including without limitation reimbursement
and other obligations with respect to surety bonds and letters of credit, (b) all obligations evidenced by notes, bonds, debentures
or similar instruments, (c) all capital lease obligations, and (d) all Contingent Obligations, including but not limited to any
sublimit contained herein.

 

“Insolvency Proceeding”
means any proceeding commenced by or against any Person or entity under any provision of the United States Bankruptcy Code, as
amended, or under any other bankruptcy or insolvency law, including assignments for the benefit of creditors, formal or informal
moratoria, compositions, extension generally with its creditors, or proceedings seeking reorganization, arrangement, or other relief.

 

“Inventory” means all present
and future inventory in which Borrower has any interest.

 

“Investment” means any beneficial
ownership of (including stock, partnership or limited liability company interest or other securities) any Person, or any loan,
advance or capital contribution to any Person.

 

“Investment Agreement” means,
collectively, Borrower’s stock purchase and other agreement(s) pursuant to which Borrower most recently issued its preferred
stock.

 

“IRC” means the Internal
Revenue Code of 1986, as amended, and the regulations thereunder.

 

“Letter of Credit” means
a commercial or standby letter of credit or similar undertaking issued by Bank at Borrower’s request.

 

“Lien” means any mortgage,
lien, deed of trust, charge, pledge, security interest or other encumbrance.

 

“Liquidity” means unrestricted Cash in
Bank.

 

“Liquidity Ratio” means
the ratio of Liquidity to all Indebtedness to Bank.

 

“Loan Documents” means,
collectively, this Agreement, any note or notes executed by Borrower, and any other document, instrument or agreement entered into
in connection with this Agreement, all as amended or extended from time to time.

 

    	3.

    	 

    

  

“Material Adverse Effect”
means a material adverse effect on: (i) the operations, business or financial condition of Borrower and its Subsidiaries taken
as a whole; (ii) the ability of Borrower to repay the Obligations or otherwise perform its obligations under the Loan Documents;
or (iii) Borrower’s interest in, or the value, perfection or priority of Bank’s security interest in the Collateral.

 

“Negotiable Collateral”
means all of Borrower’s present and future letters of credit of which it is a beneficiary, drafts, instruments (including
promissory notes), securities, documents of title, and chattel paper, and Borrower’s Books relating to any of the foregoing.

 

“New Equity” means cash
proceeds of at least Two Million Dollars ($2,000,000) received by Borrower after the Closing Date from the sale or issuance of
Borrower’s equity securities to investors acceptable to Bank.

 

“Obligations” means all
debt, principal, interest, Bank Expenses and other amounts owed to Bank by Borrower pursuant to this Agreement or any other agreement,
whether absolute or contingent, due or to become due, now existing or hereafter arising, including any interest that accrues after
the commencement of an Insolvency Proceeding and including any debt, liability, or obligation owing from Borrower to others that
Bank may have obtained by assignment or otherwise.

 

“Patents” means all patents,
patent applications and like protections including without limitation improvements, divisions, continuations, renewals, reissues,
extensions and continuations-in-part of the same.

 

“Periodic Payments” means
all installments or similar recurring payments that Borrower may now or hereafter become obligated to pay to Bank pursuant to the
terms and provisions of any instrument, or agreement now or hereafter in existence between Borrower and Bank.

 

“Permitted Indebtedness”
means:

 

(a)          Indebtedness
of Borrower in favor of Bank arising under this Agreement or any other Loan Document;

 

(b)          Indebtedness
existing on the Closing Date and disclosed in the Schedule;

 

(c)          Indebtedness
not to exceed $125,000 in the aggregate in any fiscal year of Borrower secured by a lien described in clause (c) of the defined
term “Permitted Liens,” provided such Indebtedness does not exceed at the time it is incurred the lesser of the cost
or fair market value of the property financed with such Indebtedness;

 

(d)          Subordinated
Debt;

 

(e)          Indebtedness
to trade creditors incurred in the ordinary course of business; and

 

(f)          Extensions,
refinancing and renewals of any items of Permitted Indebtedness, provided that the principal amount is not increased or the terms
modified to impose more burdensome terms upon Borrower or its Subsidiary, as the case may be.

 

“Permitted Investment” means:

 

(a)          Investments
existing on the Closing Date disclosed in the Schedule;

 

    	4.

    	 

    

 

(b)          (i)
Marketable direct obligations issued or unconditionally guaranteed by the United States of America or any agency or any State thereof
maturing within one year from the date of acquisition thereof, (ii) commercial paper maturing no more than one year from the date
of creation thereof and currently having rating of at least A-2 or P-2 from either Standard & Poor’s Corporation or Moody’s
Investors Service, (iii) Bank’s certificates of deposit maturing no more than one year from the date of investment therein,
and (iv) Bank’s money market accounts; (v) Investments in regular deposit or checking accounts held with Bank or subject
to a control agreement in favor of Bank; and (vi) Investments consistent with any investment policy adopted by the Borrower’s
board of directors;

 

(c)          Repurchases
of stock from former employees or directors of Borrower under the terms of applicable repurchase agreements (i) in an aggregate
amount not to exceed $125,000 in any fiscal year, provided that no Event of Default has occurred and, is continuing or would exist
after giving effect to the repurchases, or (ii) in any amount where the consideration for the repurchase is the cancellation of
indebtedness owed by such former employees to Borrower regardless of whether an Event of Default exists;

 

(d)          Investments
accepted in connection with Permitted Transfers;

 

(e)          Investments
of Subsidiaries in or to other Subsidiaries or Borrower and Investments by Borrower in Subsidiaries not to exceed $125,000 in the
aggregate in any fiscal year;

 

(f)          Investments
not to exceed $125,000 outstanding in the aggregate at any time consisting of (i) travel advances and employee relocation loans
and other employee loans and advances in the ordinary course of business, and (ii) loans to employees, officers or directors relating
to the purchase of equity securities of Borrower or its Subsidiaries pursuant to employee stock purchase plan agreements approved
by Borrower’s Board of Directors;

 

(g)          Investments
in unfinanced capital expenditures in any fiscal year, not to exceed $250,000;

 

(h)          Investments
(including debt obligations) received in connection with the bankruptcy or reorganization of customers or suppliers and in settlement
of delinquent obligations of, and other disputes with, customers or suppliers arising in the ordinary course of Borrower’s
business;

 

(i)          Investments
consisting of notes receivable of, or prepaid royalties and other credit extensions, to customers and suppliers who are not Affiliates,
in the ordinary course of business, provided that this subparagraph (h) shall not apply to Investments of Borrower in any Subsidiary;

 

(j)          Joint
ventures or strategic alliances in the ordinary course of Borrower’s business consisting of the licensing of
technology, the development of technology or the providing of technical support, provided that any cash Investments by
Borrower do not exceed $125,000 in the aggregate in any fiscal year; and

 

(k)          Investments
permitted under Section 7.3.

 

“Permitted Liens” means
the following:

 

(a)          Any
Liens existing on the Closing Date and disclosed in the Schedule (excluding Liens to be satisfied with the proceeds of the Credit
Extensions) or arising under this Agreement, the other Loan Documents, or any other agreement in favor of Bank;

 

(b)          Liens
for taxes, fees, assessments or other governmental charges or levies, either not delinquent or being contested in good faith by
appropriate proceedings and for which Borrower maintains adequate reserves;

 

    	5.

    	 

    

 

(c)          Liens
not to exceed $125,000 in the aggregate (i) upon or in any Equipment (other than Equipment financed by a Credit Extension) acquired
or held by Borrower or any of its Subsidiaries to secure the purchase price of such Equipment or indebtedness incurred solely
for the purpose of financing the acquisition or lease of such Equipment, or (ii) existing on such Equipment at the time of its
acquisition, in each case provided that the Lien is confined solely to the property so acquired and improvements thereon, and
the proceeds of such Equipment;

 

(d)          Liens
incurred in connection with the extension, renewal or refinancing of the indebtedness secured by Liens of the type described in
clauses (a) through (c) above, provided that any extension, renewal or replacement Lien shall be limited to the property encumbered
by the existing Lien and the principal amount of the indebtedness being extended, renewed or refinanced does not increase;

 

(e)          Liens
arising from judgments, decrees or attachments in circumstances not constituting an Event of Default under Sections 8.4 (attachment)
or 8.7 (judgments);

 

(f)          Liens
securing Subordinated Debt; and

 

(g)          inchoate
materialmen’s, mechanics, repairmen’s and similar liens arising by operation of law in the ordinary course of business
for amounts not to exceed $125,000 which are not delinquent.

 

“Permitted Transfer” means
the conveyance, sale, lease, transfer or disposition by Borrower or any Subsidiary of:

 

(a)          Inventory
in the ordinary course of business;

 

(b)          licenses
and similar arrangements for the use of the property of Borrower or its Subsidiaries in the ordinary course of business;

 

(c)          worn-out,
damaged, surplus or obsolete Equipment not financed with the proceeds of Credit Extensions or if financed with the proceeds of
a Credit Extension provided the Company replaces such Equipment with Equipment of equivalent value;

 

(d)          grants
of security interests and other Liens that constitute Permitted Liens; and

 

(e)          other
assets of Borrower or its Subsidiaries that do not in the aggregate exceed $125,000 during any fiscal year.

 

“Person” means any individual,
sole proprietorship, partnership, limited liability company, joint venture, trust, unincorporated organization, association, corporation,
institution, public benefit corporation, firm, joint stock company, estate, entity or governmental agency.

 

“Prime Rate” means the variable
rate of interest, per annum, most recently announced by Bank, as its “prime rate,” whether or not such announced rate
is the lowest rate available from Bank.

 

“Responsible Officer” means
each of the Chief Executive Officer, the Chief Operating Officer, the Chief Financial Officer, Vice President of Finance and the
Controller of Borrower, as well as any other officer or employee identified in as an Authorized Officer in the corporate resolution
delivered by Borrower to Bank in connection with this Agreement.

 

    	6.

    	 

    

  

“Schedule” means the schedule
of exceptions attached hereto and approved by Bank, if any.

 

“Soft Costs” means taxes,
shipping, warranty charges, freight discounts and installation expense.

 

“SOS Reports” means the
official reports from the Secretaries of State of each Collateral State, the state where Borrower’s chief executive office
is located, the state of Borrower’s formation and other applicable federal, state or local government offices identifying
all current security interests filed in the Collateral and Liens of record as of the date of such report.

 

“Subordinated Debt” means
any debt incurred by Borrower that is subordinated in writing to the debt owing by Borrower to Bank on terms reasonably acceptable
to Bank (and identified as being such by Borrower and Bank).

 

“Subsidiary” means any corporation,
partnership or limited liability company or joint venture in which (i) any general partnership interest or (ii) more than 50% of
the stock, limited liability company interest or joint venture of which by the terms thereof ordinary voting power to elect the
Board of Directors, managers or trustees of the entity, at the time as of which any determination is being made, is owned by Borrower,
either directly or through an Affiliate.

 

“Term Loan A Amount” means
Five Hundred Thousand Dollars $500,000.

 

“Term Loan A Availability End
Date” means the Closing Date.

 

“Term Loan A Interest-Only End
Date” means June 1, 2012.

 

“Term Loan A Maturity Date”
means December 1, 2014.

 

“Term Loan B Amount” means
Zero Dollars ($0.00); provided however, that if Borrower delivers evidence to Bank that Borrower has received the New Equity in
its entirety, “Term Loan B Amount” shall there after mean Five Hundred Thousand Dollars ($500,000).

 

“Term Loan B Availability End
Date” means July 31, 2012.

 

“Term Loan B Interest-Only End
Date” means the date that is 6 months after the date upon which Term Loan B is made.

 

“Term Loan B Maturity Date”
means the date that is 36 months after the date upon which Term Loan B is made.

 

“Trademarks” means any trademark
and servicemark rights, whether registered or not, applications to register and registrations of the same and like protections,
and the entire goodwill of the business of Borrower connected with and symbolized by such trademarks.

 

    	7.

    	 

    

 

 

	DEBTOR:	ENUMERAL BIOMEDICAL CORP.
	 	 
	SECURED PARTY:	SQUARE 1 BANK

 

EXHIBIT B

 

COLLATERAL DESCRIPTION ATTACHMENT TO LOAN AND SECURITY
AGREEMENT

 

All personal property of Borrower (herein referred to as “Borrower”
or “Debtor”) whether presently existing or hereafter created or acquired, and wherever located, including, but not
limited to:

 

(a)          all
accounts (including health-care-insurance receivables), chattel paper (including tangible and electronic chattel paper), deposit
accounts, documents (including negotiable documents), equipment (including all accessions and additions thereto), financial assets,
general intangibles (including patents, trademarks, copyrights, goodwill, payment intangibles, domain names, and software) goods
(including fixtures), instruments (including promissory notes), inventory (including all goods held for sale or lease or to be
furnished under a contract of service, and including returns and repossessions), investment property (including securities and
securities entitlements), letter of credit rights, money, and all of Debtor’s books and records with respect to any of the
foregoing, and the computers and equipment containing said books and records;

 

(b)          any
and all cash proceeds and/or noncash proceeds of any of the foregoing, including, without limitation, insurance proceeds, and
all supporting obligations and the security therefor or for any right to payment. All terms above have the meanings given to them
in the North Carolina Uniform Commercial Code, as amended or supplemented from time to time, including revised Division 9 of the
Uniform Commercial Code-Secured Transactions.

 

Notwithstanding the foregoing (including, without
limitation, any language in clause (a) above), the Collateral shall not include any of the intellectual property, in any medium,
of any kind or nature whatsoever, now or hereafter owned or acquired or received by Borrower, or in which Borrower now holds or
hereafter acquires or receives any right or interest (collectively, the “Intellectual Property”); provided, however,
that the Collateral shall include all accounts and general intangibles that consist of rights to payment and proceeds from the
sale, licensing or disposition of all or any part, or rights in, the foregoing (the “Rights to Payment”).

 

Notwithstanding the foregoing, if a judicial authority (including
a U.S. Bankruptcy Court) holds that a security interest in the underlying Intellectual Property is necessary to have a security
interest in the Rights to Payment, then the Collateral shall automatically, and effective as of December 1, 2011, include the Intellectual
Property to the extent and only to the extent necessary to permit perfection of Bank’s security interest in the Rights to
Payment, and further provided, however, that Bank’s enforcement rights with respect to any security interest in the Intellectual
Property shall be absolutely limited to the Rights to Payment only, and Bank shall have no recourse whatsoever with respect to
the underlying Intellectual Property.

 

    	1.

    	 

    

 

EXHIBIT C

 

LOAN ADVANCE/PAYDOWN
REQUEST FORM

 

[Please refer to New Borrower Kit]

 

 

 

EXHIBIT D

COMPLIANCE CERTIFICATE

 

[Please refer to New Borrower Kit]

 

    	1.

    	 

    

 

SCHEDULE OF EXCEPTIONS

 

Permitted Indebtedness (Exhibit A) – None.

 

Permitted Investments (Exhibit A) –
None.

 

Permitted Liens (Exhibit A) – None.

 

Prior Names (Section 5.5) – Enumeral Technologies, Inc.

 

Litigation (Section 5.6) – None.

 

Inbound Licenses (Section 5.12) – Exclusive License Agreement,
as may be amended from time to time, between the Company and MIT (as amended from time to time, “MIT License”). This
MIT License is not assignable and therefore is excluded from the Collateral securing the loans hereunder.

 

    	1.

    	 

    

 

FIRST AMENDMENT

TO

LOAN AND SECURITY
AGREEMENT

 

This First Amendment
to Loan and Security Agreement (the “Amendment”), is entered into as of June 12, 2012, by and between
SQUARE 1 BANK (the ‘'Bank”) and ENUMERAL BIOMEDICAL CORP. (the “Borrower”).

 

RECITALS

 

Borrower and Bank are parties
to that Loan and Security Agreement dated as of December 5, 2011 (as amended from time to time, the “Agreement”).
The parties desire to amend the Agreement in accordance with the terms of this Amendment.

 

NOW, THEREFORE, the parties agree as follows:

 

		1)	A new Section 2.5(d) is hereby added to the Agreement, as follows:

 

(d)          Success
Fee. On July 5, 2015 or such earlier date as all of the outstanding Obligations hereunder are repaid in full, a fee equal
to $15,000, which shall be nonrefundable. This Section 2.5(d) shall survive any termination of this Agreement.

 

	 	2)	The first paragraph of Section 6.2 of the
Agreement is hereby amended and restated, as follows:

 

6.2          Financial
Statements, Reports, Certificates. Borrower shall deliver to Bank: (i) as soon as available, but in any event within 30
days after the end of each calendar month, a company prepared consolidated and consolidating balance sheet, cash flow
statement and income statement covering Borrower’s operations during such period, in a form reasonably acceptable to
Bank and certified by a Responsible Officer; (ii) as soon as available, but in any event within 180 days after the end of
Borrower’s fiscal year, audited (or such other level as is required by the Investment Agreement) consolidated and
consolidating financial statements of Borrower prepared in accordance with GAAP, consistently applied, together with an
opinion on such financial statements of an independent certified public accounting firm reasonably acceptable to Bank which
is either unqualified or qualified only for going concern, so long as in the case of the qualified opinion it is either
consented to in writing by Bank or in the alternative if following the delivery of such financial statements the Bank does
not consent to such qualified Borrower’s investors will provide additional equity as needed within 30 days after notice
from the Bank of such non consent to the qualified financial statements or otherwise; provided however, that the audited
consolidated and consolidating financial statements of Borrower for fiscal years 2011 and 2012 shall be delivered to Bank on
or before July 1, 2013, (iii) annual budget approved by Borrower’s Board of Directors as soon as available but not
later than 30 days before the beginning of the applicable calendar year, provided however, that for the 2012 annual budget
only, Borrower shall provide the 2012 annual budget approved by Borrower’s Board of Directors as soon as available but
not later than March 1, 2012; (iv) if applicable, copies of all statements, reports and notices sent or made available
generally by Borrower to its security holders or to any holders of Subordinated Debt and all reports on Forms 10-K and 10-Q
filed with the Securities and Exchange Commission; (v) promptly upon receipt of notice thereof, a report of any legal actions
pending or threatened against Borrower or any Subsidiary that could reasonably be expected to result in damages or costs to
Borrower or any Subsidiary of $250,000 or more; (vi) promptly upon receipt, each management letter prepared by
Borrower’s independent certified public accounting firm regarding Borrower’s management control systems, (vii)
such budgets, sales projections, operating plans or other financial information generally prepared by Borrower in the
ordinary course of business as Bank may reasonably request from time to time.

 

Enumeral Biomedical Corp. – 1st Amendment to
LSA

 

    	1

    	 

    

 

		3)	Section 6.7(b) of the Agreement is hereby amended and restated, as follows:

 

(b)          Cash
Burn. Tested monthly and calculated on a trailing six-months average, a Cash Burn of not more than the amounts shown in column
B below for the corresponding reporting period in column A.

 

	A	 	B	 
	Reporting Period Ending On	 	 	Maximum
                                         Cash Burn	 
	April 30, 2012	 	$	1,699,300	 
	May 31, 2012	 	$	1,658,900	 
	June 30, 2012	 	$	1,584,100	 
	July 31, 2012	 	$	2,020,729	 
	August 31, 2012	 	$	2,149,201	 
	September 30, 2012	 	$	1,997,476	 
	October 31, 2012	 	$	2,021,432	 
	November 30, 2012	 	$	2,079,360	 
	December 31, 2012	 	$	1,746,866	 

 

Beginning with December 1, 2012, Bank and Borrower hereby agree
that, on or before December 1st of each year during the term of this Agreement, Borrower shall provide to Bank a fully-funded budget
for the upcoming calendar year, and Bank shall use that budget to establish the maximum Cash Burn amounts for the upcoming year,
with such maximum amounts being incorporated herein by an amendment, which shall be promptly executed by Bank and Borrower.

 

	 	4)	The following definitions in Exhibit A to the Agreement are hereby amended and restated, as follows:

 

“Equipment Availability End Date”
December 5, 2012.

 

“Equipment Interest-Only End Date”
means December 5, 2012.

 

“Equipment Maturity Date” means
July 5, 2015.

 

“Term Loan A Interest-Only End Date”
means December 5, 2012.

 

Enumeral Biomedical Corp.
– 1st Amendment to LSA

 

    	2

    	 

    

 

“Term Loan A Maturity Date” means July 5, 2015.

 

“Term Loan B Availability End Date” means December 5,
2012.

 

“Term Loan B Interest-Only End Date” means December
5, 2012.

 

“Term Loan B Maturity Date” means July 5, 2015.

 

	 	5)	Unless otherwise defined, all initially capitalized terms in this Amendment shall be as defined in the Agreement. The Agreement, as amended hereby, shall be and remain in full force and effect in accordance with its respective terms and hereby is ratified and confirmed in all respects. Except as expressly set forth herein, the execution, delivery, and performance of this Amendment shall not operate as a waiver of, or as an amendment of, any right, power, or remedy of Bank under the Agreement, as in effect prior to the date hereof. Borrower ratifies and reaffirms the continuing effectiveness of all agreements entered into in connection with the Agreement.

 

	 	6)	Borrower represents and warrants that the representations and warranties contained in the Agreement are true and correct as of the date of this Amendment.

 

	 	7)	This Amendment may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one instrument.

 

	 	8)	As a condition to the effectiveness of this Amendment, Bank shall have received, in form and substance satisfactory to Bank, the following:

 

a)          this Amendment, duly executed by Borrower;

 

b)          an
officer’s certificate of Borrower with respect to incumbency and resolutions authorizing the execution and
delivery of this Amendment;

 

c)          a Second Warrant to Purchase Stock, duly executed by Borrower;

 

d)          payment
of a $5,500 facility fee, which may be debited from any of Borrower’s accounts;

 

e)          payment of all Bank Expenses, including Bank’s expenses
for the documentation of this Amendment and any related documents, and any UCC, good standing and intellectual property search
or filing fees, which may be debited from any of Borrower’s accounts; and

 

f)         such other
documents and completion of such other matters, as Bank may reasonably deem necessary or appropriate.

 

[Signature Page Follows]

 

Enumeral Biomedical Corp.
– 1st Amendment to LSA

 

    	3

    	 

    

 

IN WITNESS WHEREOF, the undersigned have executed this Amendment
        as of the first date above written.

 

	ENUMERAL BIOMEDICAL CORP.	 	SQUARE 1 BANK
	 	 	 
	By:	/s/ John J. Rydzewski	 	By:	/s/ Zack Robbins
	Name:	John J. Rydzewski	 	Name:	 Zack Robbins
	Title:	Executive Chairman 	 	Title:	AVP

 

[Signature Page to First Amendment to Loan and Security Agreement]

 

Enumeral Biomedical Corp.
– 1st Amendment to LSA

 

    	4

    	 

    

 

SECOND AMENDMENT

TO 

LOAN AND SECURITY
AGREEMENT

 

This Second Amendment to Loan and Security
Agreement (the “Amendment”), is made and entered into as of August 9, 2013, by and between SQUARE 1
BANK (the “Bank”) and ENUMERAL BIOMEDICAL CORP. (the “Borrower”).

 

RECITALS

 

Borrower and Bank are parties to that Loan and Security Agreement
dated as of December 5, 2011 (as amended from time to time, the “Agreement”). The parties desire to amend
the Agreement in accordance with the terms of this Amendment.

 

NOW, THEREFORE, the parties agree as follows:

 

		1)	Section 6.7 of the Agreement is hereby amended and restated, as follows:

 

6.7          Financial
Covenants. Borrower shall at all times maintain at least one of the following financial ratios and covenants;
provided, however, that from August 9, 2013 through the remainder of the 2013 calendar year, Borrower shall not be required to
maintain any of the financial ratios and covenants set forth in this Section 6.7:

 

(a)          Liquidity
Ratio. A Liquidity Ratio of at least 1.25 to 1.00; or

 

(b)          Cash
Burn. Tested monthly and calculated on a trailing six-months average, a Cash Bum of not more than the amounts shown in
column B below for the corresponding reporting period in column A.

 

	A	 	B	 
	Reporting Period Ending On	 	 	Maximum
                                         Cash Burn	 
	January 31, 2013	 	$	1,807,516	 
	February 28, 2013	 	$	1,917,511	 
	March 31, 2013	 	$	1,826,044	 
	April 30, 2013	 	$	1,700,391	 
	May 31, 2013	 	$	1,551,829	 
	June 30, 2013	 	$	1,646,901	 
	July 31, 2013	 	$	1,618,389	 
	August 31, 2013	 	$	1,574,255	 
	September 30, 2013	 	$	1,695,620	 
	October 31, 2013	 	$	1,762,491	 
	November 30, 2013	 	$	1,835,388	 
	December 31, 2013	 	$	2,000,835	 

 

Enumeral Biomedical Corp. – 2nd Amendment to
LSA Execution1

 

    	1

    	 

    

 

Bank and Borrower hereby agree that, on or before December 15th
of each year during the term of this Agreement, Borrower shall provide to Bank a fully-funded budget for the upcoming calendar
year, and Bank shall use that budget to establish the maximum Cash Bum amounts for the upcoming year, with such maximum amounts
being incorporated herein by an amendment, which shall be promptly executed by Bank and Borrower.

 

	 	2)	The following new Section 6.10 is hereby added to the Agreement, as follows:

 

6.10        Milestone
Covenants. Borrower shall achieve each; of the following milestones:

 

(a)          Minimum
Equity Milestone. On or before October 31, 2013, Borrower shall have received net Cash proceeds from the sale or issuance of
Borrower’s equity securities in an amount not less than $750,000 (the “Initial Equity Event”).

 

(b)          Term
Sheet Milestone. On or before December 31, 2013, Borrower’s receipt of a signed and accepted term sheet from one or more
investor(s) acceptable to Bank for the sale or issuance of Borrower’s equity securities on terms and conditions which shall
result in net Cash proceeds in amount not less than $2,500,000 (the “Term Sheet”); provided, however, the net Cash
proceeds required under the Term Sheet shall be reduced by: (i) Cash proceeds which are in excess of the required Cash amount pursuant
the Initial Equity Event, and (ii) funds to be received in the 2014 calendar year pursuant to signed term sheets, signed proposals
or signed contracts for new or expansion of existing partnership(s) or collaboration(s) that are also included in Borrower’s
2014 Board approved plan to be in effect beginning January 1, 2014; provided, further, that Borrower’s 2014 Board approved
plan evidences Borrower’s ability to retain a Cash balance throughout the remainder of the 2014 calendar year.

 

	 	3)	Unless otherwise defined, all initially capitalized terms in this Amendment shall be as defined in the Agreement. The Agreement, as amended hereby, shall be and remain in full force and effect in accordance with its respective terms and hereby is ratified and confirmed in all respects. Except as expressly set forth herein, the execution, delivery, and performance of this Amendment shall not operate as a waiver of, or as an amendment of, any right, power, or remedy of Bank under the Agreement, as in effect prior to the date hereof. Borrower ratifies and reaffirms the continuing effectiveness of all agreements entered into in connection with the Agreement.

 

	 	4)	Borrower represents and warrants that the representations and warranties contained in the Agreement are true and correct as of the date of this Amendment.

 

	 	5)	This Amendment may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one instrument.

 

	 	6)	As a condition to the effectiveness of this Amendment, Bank shall have received, in form and substance satisfactory to Bank, the following:

 

b)          this Amendment, duly executed by Borrower;

 

Enumeral Biomedical Corp. – 2nd Amendment to
LSA Execution2

 

    	2

    	 

    

 

c)          payment of all Bank Expenses, including Bank’s expenses
for the documentation of this Amendment and any related documents, and any UCC, good standing and intellectual property search
or filing fees, which may be debited from any of Borrower’s accounts; and

 

b)          such other documents and completion of such other matters,
as Bank may reasonably deem necessary or appropriate.

 

[Signature Page Follows]

 

Enumeral Biomedical Corp. – 2nd Amendment to
LSA Execution3

 

    	3

    	 

    

 

IN WITNESS WHEREOF, the undersigned have executed this Amendment
as of the first date above written.

 

	ENUMERAL BIOMEDICAL CORP.	 	SQUARE 1 BANK
	 	 	 	 	 
	By:	/s/ Derek Brand	 	By:	/s/ Zack Robbins
	Name:	Derek Brand	 	Name:	Zack Robbins
	Title:	VP Business Development & Finance	 	Title:	AVP

 

[Signature Page to Second Amendment to Loan and Security Agreement]

 

Enumeral Biomedical Corp. – 2nd Amendment to
LSA Execution4

 

    	4

    	 

    

 

THIRD AMENDMENT

TO

LOAN AND SECURITY AGREEMENT

 

This Third Amendment to Loan and Security
Agreement (this “Amendment”), is made and entered into as of February 3, 2014, by and between SQUARE
1 BANK (“Bank”) and ENUMERAL BIOMEDICAL CORP. (“Borrower”).

 

RECITALS

 

Borrower and Bank are parties to that Loan
and Security Agreement dated as of December 5, 2011 (as amended from time to time, the “Agreement”).
The parties desire to amend the Agreement in accordance with the terms of this Amendment.

 

NOW, THEREFORE, the parties agree as follows:

 

		1)	Section 6.7 of the Agreement is hereby amended and restated, as follows:

 

6.7           Financial
Covenants. Borrower shall maintain the following financial covenants:

 

(a)          Remaining
Months Cash. Beginning on the date on which Borrower achieves Equity Milestone I and continuing at all times thereafter. Borrower
shall maintain Remaining Months Cash of at least 3.0. For the avoidance of doubt, Remaining Months Cash shall be tested on a daily
basis, using the Cash Burn level for the most recent trailing- three-month period for which reporting is available.

 

(b)          Term
Sheet Requirement for Forthcoming RMC Violation. Before Borrower’s Remaining Months Cash falls below 3.0 in violation
of Section 6.7(a) above, Borrower shall submit to Bank a signed term sheet for the issuance of Borrower's equity securities, with
net Cash proceeds from such sale or issuance of at least $2,000,000, and otherwise on terms and from investors acceptable to Bank.
Borrower shall receive such net Cash proceeds within 30 days after the signed term sheet is delivered to Bank. During the period
after Bank has received the signed term sheet but before Borrower receives the required net Cash proceeds, Borrower shall be required
to maintain Remaining Months Cash of at least 2.0 instead of the level required by Section 6.7(a) above.

 

		2)	Section 6.10 of the Agreement is hereby amended and restated, as follows:

 

6.10         Milestone
Covenants. Borrower shall achieve each of the following milestone covenants:

 

(a)          Equity
Milestone I. Borrower shall achieve Equity Milestone I.

 

(b)          Equity
Milestone II. Borrower shall achieve Equity Milestone II.

 

Enumeral Biomedical Corp.
– 3rd Amendment to LSA

 

    	1

    	 

    

 

		3)	Section 8.2(a) of the Agreement is hereby amended and restated, as follows:

 

(a)          If
Borrower fails to perform any obligation under Sections 6.2 (financial reporting), 6.4 (taxes), 6.5 (insurance), 6.6 (primary
accounts), 6.7 (financial covenants), or 6.10 (milestone covenants), or violates any of the covenants contained in Article 7 of
this Agreement; or

 

		4)	The following defined terms are hereby added to Exhibit A to the Agreement, as follows:

 

“Equity Milestone I” means Borrower’s
receipt, after February 1, 2014 but on or before March 31, 2014, of net Cash proceeds of at least $2,000,000 from the sale or issuance
of Borrower’s equity securities to investors acceptable to Bank, which acceptance will not be unreasonably withheld.

 

“Equity Milestone II” means Borrower's
receipt, after February 1, 2014 but on or before June 30, 2014, of net Cash proceeds of at least $4,000,000 from the sale or issuance
of Borrower’s equity securities to investors acceptable to Bank, which acceptance will not be unreasonably withheld.

 

“Remaining Months Cash” means (i)
unrestricted Cash at Bank, divided by (ii) the monthly average of trailing-three-months Cash Burn.

 

	 	5)	The following defined term in Exhibit A to the Agreement is hereby amended and restated, as follows:

 

“Cash Burn” means an amount equal
to the prior period’s ending Cash minus the current period’s ending Cash that has been adjusted for any changes to
Cash as a result of borrowings and repayments of borrowings, proceeds from the sale of equity for Cash and the exercise of stock
options or warrants for Cash, and paid-in-capital and minority interest.

 

	 	6)	The defined terms “Liquidity” and “Liquidity Ratio” and their respective definitions in Exhibit A to the Agreement are hereby deleted.

 

		7)	Unless otherwise defined, all initially capitalized terms in this Amendment shall be as defined
in the Agreement. The Agreement, as amended hereby, shall be and remain in full force and effect in accordance with its respective
terms and hereby is ratified and confirmed in all respects. Except as expressly set forth herein, the execution, delivery, and
performance of this Amendment shall not operate as a waiver of, or as an amendment of, any right, power, or remedy of Bank under
the Agreement, as in effect prior to the date hereof. Borrower ratifies and reaffirms the continuing effectiveness of all agreements
entered into in connection with the Agreement.

 

		8)	Borrower represents and warrants that the representations and warranties contained in the Agreement
are true and correct as of the date of this Amendment.

 

		9)	This Amendment may be executed in two or more counterparts, each of which shall be deemed an original,
but all of which together shall constitute one instrument.

 

	 	10)	As a condition to the effectiveness of
this Amendment, Bank shall have received, in form and substance satisfactory to Bank, the following:

 

Enumeral Biomedical Corp. –
3rd Amendment to LSA

 

    	2

    	 

    

 

	a)	this Amendment, duly executed by Borrower;

 

	b)	evidence that Borrower has received at least $635,000 in net Cash proceeds from the sale or issuance of Borrower’s Subordinated Debt securities to investors acceptable to Bank;

 

	a)	a subordination agreement, duly executed by each of Harris & Harris Group, Inc., Allan Rothstein, John J. Rydzewski, Michael Weiss, Emanuele Ostuni, and Peter Green and acknowledged by Borrower;

 

	b)	payment of all Bank Expenses, including Bank’s expenses for the documentation of this Amendment and any related documents, and any UCC, good standing and intellectual property search or filing fees, which may be debited from any of Borrower’s accounts; and

 

	c)	such other documents and completion of such other matters, as Bank may reasonably deem necessary or appropriate.

 

[Signature Page Follows]

 

Enumeral Biomedical Corp.
– 3rd Amendment to LSA

 

    	3

    	 

    

 

IN WITNESS WHEREOF, the undersigned have executed this Amendment
as of the first date above written.

 

	ENUMERAL BIOMEDICAL CORP.	 	SQUARE 1 BANK
	 	 	 	 	 
	By:	/s/ Derek Brand	 	By:	/s/ Zack Robbins
	Name:	Derek Brand	 	Name:	Zack Robbins
	Title:	VP Business Development Director of Finance	 	Title:	AVP

 

[Signature Page to Third Amendment to Loan and Security Agreement]

 

Enumeral Biomedical Corp.
– 3rd Amendment to LSA

 

    	4

    	 

    

 

 

FOURTH AMENDMENT

TO

LOAN AND SECURITY AGREEMENT

 

This
Fourth Amendment to Loan and Security Agreement (this “Amendment”),
is made and entered into as of June 26, 2014, by and between SQUARE 1 BANK (“Bank”)
and ENUMERAL BIOMEDICAL CORP. (“Borrower”).

 

RECITALS

 

Borrower
and Bank are parties to that Loan and Security Agreement dated as of December 5, 2011 (as amended from time to time, the “Agreement”).
The parties desire to amend the Agreement in accordance with the terms of this
Amendment.

 

NOW,
THEREFORE, the parties agree as follows:

 

		1)	Bank hereby waives Borrower's violation of the Remaining Months
Cash covenant, as set forth in Section 6.7(a) of the Agreement (as in effect prior to this Amendment), for all the dates from June
12, 2014 through the date of this Amendment.

 

		2)	Section 6.7(a) of the Agreement is hereby amended and restated,
as follows:

 

(a)     Remaining
Months Cash. Beginning on August
1, 2014 and continuing at all times thereafter, Borrower shall maintain Remaining Months Cash of at least 3.0. For the avoidance
of doubt, Remaining Months Cash shall be tested on a daily basis, using the Cash Burn level for the most recent trailing-three-month
period for which reporting is available.

 

		3)	A new Section 6.7(c) is hereby added to the Agreement, as follows:

 

(c)     Minimum
Cash. From June 26, 2014 through August 1, 2014, a balance of unrestricted Cash at Bank
of not less than $300,000, monitored on a daily basis.

 

		4)	The following defined term set forth in Exhibit A to the Agreement
is hereby amended and restated, as follows:

 

“Equity
Milestone II” means Borrower’s receipt, after February 1, 2014 but on or before August 1, 2014, of net Cash proceeds
of at least $4,000,000 from the sale or issuance of Borrower's equity securities to investors acceptable to Bank, which acceptance
will not be unreasonably withheld.

 

		5)	Unless otherwise defined, all initially capitalized terms in
this Amendment shall be as defined in the Agreement. The Agreement, as amended hereby, shall be and remain in full force and effect
in accordance with its respective terms and hereby is ratified and confirmed in all respects. Except as expressly set forth herein,
the execution, delivery, and performance of this Amendment shall not operate as a waiver of, or as an amendment of, any right,
power, or remedy of Bank under the Agreement, as in effect prior to the date hereof. Borrower ratifies and reaffirms the continuing
effectiveness of all agreements entered into in connection with the Agreement.

 

Enumeral
Biomedical Corp. – 4th Amendment to LSA

 

    	1

    	 

    

 

		6)	Borrower represents and warrants that the representations and
warranties contained in the Agreement are true and correct as of the date of this Amendment.

 

		7)	This Amendment may be executed in two or more counterparts, each
of which shall be deemed an original, but all of which together shall constitute one instrument.

 

		8)	As a condition to the effectiveness of this Amendment, Bank shall
have received, in form and substance satisfactory to Bank, the following:

 

		a)	this Amendment, duly executed by Borrower;

 

		b)	payment of a $500 facility fee, which may be debited from any
of Borrower’s accounts;

 

		a)	payment of all Bank Expenses, including Bank’s expenses
for the documentation of this Amendment and any related documents, and any UCC, good standing and intellectual property search
or filing fees, which may be debited from any of Borrower’s accounts; and

 

		b)	such other documents and completion of such other matters, as
Bank may reasonably deem necessary or appropriate.

 

[Signature
Page Follows]

 

Enumeral
Biomedical Corp. –
4th Amendment to LSA

 

    	2

    	 

    

 

IN WITNESS WHEREOF,
the undersigned have executed this Amendment as of the first date above written.

 

	ENUMERAL BIOMEDICAL CORP.	 	SQUARE 1 BANK
	 	 	 	 	 
	By:	/s/ Derek Brand	 	By:	/s/
    John Orlando
	Name :
    	Derek Brand	 	Name:
    	John
    Orlando
	Title: 	VP of Business Development & Director, Finance	 	Title:
    	AVP

 

[Signature
Page to Fourth Amendment to Loan and Security Agreement]

 

Enumeral Biomedical
Corp. – 4th
Amendment to LSA

 

    	3

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