Document:

Loan Modification Agreement

 Exhibit 10.1 
 LOAN MODIFICATION AGREEMENT 
 This Loan Modification Agreement is entered into as of March 26, 2008, by
and between ISTA PHARMACEUTICALS, INC., a Delaware corporation (the “Borrower”) and SILICON VALLEY BANK (“Bank”). 
 1. DESCRIPTION OF
EXISTING INDEBTEDNESS: Among other indebtedness which may be owing by Borrower to Bank, Borrower is indebted to Bank pursuant to, among other documents, a Loan and Security Agreement, dated on or about December 16, 2005, as may be amended
from time to time, (the “Loan Agreement”). Defined terms used but not otherwise defined herein shall have the same meanings as in the Loan Agreement. 
 Hereinafter, all indebtedness owing by Borrower to Bank shall be referred to as the “Indebtedness.” 
 2. DESCRIPTION OF
COLLATERAL. Repayment of the Indebtedness is secured by the Collateral as described in the Loan Agreement. 
 Hereinafter, the above-described security
documents, together with all other documents securing repayment of the Indebtedness shall be referred to as the “Security Documents”. Hereinafter, the Security Documents, together with all other documents evidencing or securing the
Indebtedness shall be referred to as the “Existing Loan Documents”. 
 3. DESCRIPTION OF CHANGE IN TERMS. 
  

	 	A.	Modification to Loan Agreement. 

  

	 	1.	The definition of “Revolving Line Maturity Date” in Section 13.1 is hereby amended and restated in its entirety to read as follows: 

 “Revolving Line Maturity Date” is the earliest of (a) March 30, 2009; or (b) the date Bank exercises its remedies under
Section 9.1(a). 
 4. CONSISTENT CHANGES. The Existing Loan Documents are hereby amended wherever necessary to reflect the changes described
above. 
 5. PAYMENT OF LOAN FEE. Borrower shall pay Lender a fee (the “Loan Fee”) equal to $25,000, plus all out-of-pocket expenses.

 6. NO DEFENSES OF BORROWER. Borrower agrees that, as of the date hereof, it has no defenses against the obligations to pay any amounts under the
Indebtedness. 
 7. CONTINUING VALIDITY. Borrower understands and agrees that in modifying the existing Indebtedness, Bank is relying upon
Borrower’s representations, warranties, and agreements, as set forth in the Existing Loan Documents. Except as expressly modified pursuant to this Loan Modification Agreement, the terms of the Existing Loan Documents remain 

  

 1 

 
unchanged and in full force and effect. Bank’s agreement to modifications to the existing Indebtedness pursuant to this Loan Modification Agreement in
no way shall obligate Bank to make any future modifications to the Indebtedness. Nothing in this Loan Modification Agreement shall constitute a satisfaction of the Indebtedness. 
 8. CONDITIONS. The effectiveness of this Loan Modification Agreement is conditioned upon payment of the Loan Fee. 
 This Loan Modification Agreement is executed as of the date first written above. 
  

									
	 BORROWER:
  
 ISTA PHARMACEUTICALS, INC.
	 		 	 BANK:
  
 SILICON VALLEY BANK

					
	By:	 	/s/ Lauren P. Silvernail	 		 	By:	 	/s/ Victor Le
	Name: Lauren P. Silvernail	 		 	Name: Victor Le
	Title: Chief Financial Officer	 		 	Title: Relationship Manager

  

 2Specimen Unit Certificate

 Exhibit 4.1 
  

					
	NUMBER	  	RAI ACQUISITION CORP.	  	UNITS
	U	  		  	

  

					
	SEE REVERSE FOR CERTAIN DEFINITIONS	  	CUSIP                        	  	

 UNITS CONSISTING OF ONE SHARE OF COMMON STOCK AND ONE WARRANT 
 EACH TO PURCHASE ONE SHARE OF COMMON STOCK 
 THIS CERTIFIES THAT 
  

			
	is the owner of	  	Units.

 Each Unit (“Unit”) consists of one (1) share of common stock, par value $.0001 per share
(“Common Stock”), of RAI ACQUISITION CORP., a Delaware corporation (the “Company”), and one warrant (the “Warrant”). Each Warrant entitles the holder to purchase one (1) share of Common Stock for $7.50 per share
(subject to adjustment). Each Warrant will become exercisable on the later of (i) the Company’s completion of a business combination or
(ii),                     2009 and will expire unless exercised before 5:00 p.m., New York City Time, on
                    , 2013, or earlier upon redemption (the “Expiration Date”). The Company will use its best efforts to
cause a registration statement relating to common stock issuable upon exercise of a Warrant to become effective on or prior to the commencement of the warrant exercise period and to maintain the effectiveness of such registration statement until the
Expiration Date. A Warrant is not exercisable unless, at the time of exercise, the common stock for which the Warrant may be exercised is the subject of an effective registration statement under the Securities Act of 1933, as amended, and a
prospectus relating to such common stock is current, and such common stock has been registered under or deemed to be exempt from registration under the securities laws of the state of residence of the holder of the Warrant. The Company is not
obligated to settle the Unit or the Warrant for cash, even if the Warrant is not exercisable due to the failure by the Company to maintain an effective registration statement. The Common Stock and Warrants comprising the Units represented by this
certificate will trade separately on                     ; provided, however, in no event will the representative of the underwriters
allow separate trading of the Common Stock and Warrants until the Company files an audited balance sheet reflecting the Company’s receipt of the gross proceeds of the offering. The terms of the Warrants are governed by a Warrant Agreement,
dated as of                      , 2008, between the Company and American Stock Transfer & Trust Company, as Warrant Agent,
and are subject to the terms and provisions contained therein, all of which terms and provisions the holder of this certificate consents to by acceptance hereof. Copies of the Warrant Agreement are on file at the office of the Warrant Agent at 59
Maiden Lane, New York, New York 10038, and are available to any Warrant holder on written request and without cost. This certificate is not valid unless countersigned by the Transfer Agent and Registrar of the Company. 
 Witness the facsimile seal of the Company and the facsimile signature of its duly authorized officers. 
  

	
	
	
	 RAI ACQUISITION CORP.
 CORPORATE
 SEAL
 2007

 DELAWARE 
  

							
	Chief Executive Officer	 		  	Secretary	  	

 Countersigned and Registered by: 
 American Stock Transfer & Trust Company, 
 as Transfer Agent and Registrar 
  

			
	By:	 	  

		 	Authorized Signature

 RAI ACQUISITION CORP. 
 The Company will furnish without charge to each stockholder who so requests, a statement of the powers, designations, preferences and relative,
participating, optional or other special rights of each class of stock or series thereof of the Company and the qualifications, limitations, or restrictions of such preferences and/or rights. 
 The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were written out in full
according to applicable laws or regulations: 
  

							
	TEN COM	  	as tenants in common	  	 UNIF GIFT/TRANSFERS
 MIN ACT
	 	                Custodian                
	TEN ENT	  	as tenants by the entireties	  		 	(Cust)                    (Minor)
	JT TEN	  	 as joint tenants with right of survivorship
 and not as tenants in common
	  		 	under Uniform Gifts/Transfers to Minors Act
		  		  		 	  

		  		  		 	(State)

 Additional Abbreviations may also be used though not in the above list. 
 For value received             , hereby sell, assign and transfer unto

  

			
	 PLEASE INSERT SOCIAL SECURITY
 OR OTHER IDENTIFYING
NUMBER
 OF ASSIGNEE
  
	 	

	
	  

	  

  

					
	  

	(PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)	 		 	
	  

	  

	  
	 	Units	 	
	represented by the within Certificate, and do hereby irrevocably constitute and appoint	 		 	
	  
	 	Attorney	 	
	to transfer the said Units on the books of the within named Company will full power of substitution in the premises.	 		 	

  

							
	Dated:	 	                                  
	 		 	  

		 		 		 	NOTICE: The signature to this assignment must correspond with the name as written upon the face of the certificate in every particular, without alteration or enlargement or any change
whatever.

  

			
	  

	Signature(s) Guaranteed:	 	
	
	THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED
SIGNATURE GUARANTEE MEDALLION PROGRAM, PURSUANT TO S.E.C. RULE 17Ad-15).Specimen Common Stock Certificate

 Exhibit 4.2 
 RAI ACQUISITION CORP. 
  

			
	 NUMBER
	  	
	 C
	  	SHARES

 INCORPORATED UNDER THE LAWS OF THE STATE OF DELAWARE 
 COMMON STOCK 
  

			
		  	CUSIP
		
		  	SEE REVERSE FOR
		  	CERTAIN DEFINITIONS

  

					
	THIS CERTIFIES THAT	 	  
	 	

 IS THE OWNER OF 
 FULLY PAID AND NON-ASSESSABLE SHARES OF THE COMMON STOCK, PAR VALUE $.0001 PER SHARE, OF 
 RAI ACQUISITION
CORP. 
 (hereinafter, the “Company”) transferable on the books of the Company in person or by duly authorized attorney upon surrender of this
certificate properly endorsed. 
 This certificate is not valid unless countersigned by the Transfer Agent and registered by the Registrar. 
 Witness the seal of the Company and the facsimile signatures of its duly authorized officers. 
 Dated: 

					
	  
	  	 RAI ACQUISITION CORP.
 CORPORATE
 SEAL 2007
 DELAWARE
	  	  

	CHIEF EXECUTIVE OFFICER	  	  	SECRETARY

 Countersigned and Registered by: 
  

			
		 	 American Stock Transfer & Trust Company,
 as Transfer Agent and Registrar

		
	By:	 	  

		 	Authorized Signature

 The following abbreviations, when used in the inscription on the face of this certificate, shall be
construed as though they were written out in full according to applicable laws or regulations: 
  

							
	TEN COM	  	as tenants in common	  	UNIF GIFT/TRANSFERS MIN ACT	  	                 Custodian                
 
	TEN ENT	  	as tenants by the entireties	  		  	(Cust)                     (Minor)
	JT TEN	  	 as joint tenants with right of survivorship
 and not as
tenants in common
	  		  	under Uniform Gifts/Transfers to Minors Act
		  		  		  	  

		  		  		  	(State)

 Additional Abbreviations may also be used though not in the above list. 
 RAI ACQUISITION CORP. 
 The Company
will furnish without charge to each stockholder who so requests the powers, designations, preferences and relative, participating, optional or other special rights of each class of stock or series thereof of the Company and the qualifications,
limitations, or restrictions of such preferences and/or rights. This certificate and the shares represented thereby are issued and shall be held subject to all the provisions of the Certificate of Incorporation and all amendments thereto and
resolutions of the Board of Directors providing for the issue of shares of Common Stock (copies of which may be obtained from the secretary of the Company), to all of which the holder of this certificate by acceptance hereof assents. 
 For value
received                         , hereby sell, assign and transfer unto 
  

							
	
	 PLEASE INSERT SOCIAL SECURITY OR
 OTHER IDENTIFYING NUMBER OF ASSIGNEE
	  	
				
	  
 	 	  	 	  	  	 
				
	  
 	 	  	 	  	  	 
		 		 		  	
	 (PLEASE PRINT OR TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)
	  	
	  
	  	
	  
	  	
	  
	 	 shares
	  	
	 of the capital stock represented by the within Certificate, and do hereby irrevocably constitute and appoint
	  	
	  
	 	Attorney	  	
	to transfer the said stock on the books of the within named Company will full power of substitution in the premises.	  	

  

									
	 Dated: 
	 	  
	 		 		  	  

		 	  
	 		 		  	NOTICE: The signature to this assignment must correspond with the name as written upon the face of the certificate in every particular, without alteration or enlargement or any change
whatever.
	  

	 Signature(s) Guaranteed:
	  	

  
 THE SIGNATURE(S)
SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION (BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED SIGNATURE GUARANTEE MEDALLION PROGRAM, PURSUANT TO S.E.C. RULE 17Ad-15). 
 The holder of this certificate shall be entitled to receive funds from the trust fund only in the event of the Company’s liquidation or if the holder seeks to
convert his respective shares into cash upon a business combination which he voted against and which is actually completed by the Company. In no other circumstances shall the holder have any right or interest of any kind in or to the trust fund.

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