Document:

EX-10.10

 Exhibit 10.10 

June 8, 2020 
 Ken Song,
M.D. 
 6192 Quail Run St 
 San
Diego, CA 92130 
  

	 Re:
	 Separation and Consulting Agreement 

Dear Ken: 
 This
letter sets forth the substance of the separation and consulting agreement (the “Agreement”) that Metacrine, Inc. (the “Company”) is offering to you. 

1. SEPARATION DATE. Your last day of work with the Company and your employment
termination date is June 8, 2020 (the “Separation Date”). The Company is in receipt of your resignation as the President, Chief Executive Officer and member of the Board of Directors of the Company as of the Separation Date and
this agreement confirms such resignation as of the Separation Date. On or about the Separation Date, the Company will pay you all accrued salary, and all accrued and unused vacation (if any) earned through the Separation Date, subject to standard
payroll deductions and withholdings. You are entitled to these payments regardless of whether or not you sign this Agreement. 

2. HEALTHCARE BENEFITS. To the extent provided by the federal COBRA law or, if
applicable, state insurance laws, and by the Company’s current group health insurance policies, you will be eligible to continue your group health insurance benefits at your own expense. Later, you may be able to convert to an individual policy
through the provider of the Company’s health insurance, if you wish. Although the Company is not required to provide you any severance benefits, if you timely sign this Agreement, allow the releases set forth herein to become effective, and
remain in compliance with all obligations contained in this Agreement, then the Company will provide you with the following severance benefits: 

(i) COBRA Premiums. If you timely elect continued coverage under COBRA, the Company will pay your COBRA premiums to
continue your coverage (including coverage for eligible dependents, if applicable) (“COBRA Premiums”) through the period (the “COBRA Premium Period”) starting on the Separation Date and ending on the earliest to
occur of: (i) December 31, 2020; (ii) the date that you terminate the Consulting Period pursuant to Section 3(j) hereof; (iii) the date you become eligible for group health insurance coverage through a new employer; or
(iv) the date you cease to be eligible for COBRA continuation coverage for any reason, including plan termination. In the event you become covered under another employer’s group health plan or otherwise cease to be eligible for COBRA
during the COBRA Premium Period, you must immediately notify the Company in writing of such event. 
 (ii) Special Cash
Payments in Lieu of COBRA Premiums. Notwithstanding the foregoing, if the Company determines, in its sole discretion, that it cannot pay the COBRA Premiums without a substantial risk of violating applicable law (including, without limitation,
Section 2716 of the Public Health Service Act), the Company instead shall pay to you, 

 Ken Song 

June 8, 2020 
 Page 
2
 of 11 
  

 
on the first day of each calendar month, a fully taxable cash payment equal to the applicable COBRA premiums for that month (including premiums for you and your eligible dependents who have
elected and remain enrolled in such COBRA coverage), subject to applicable tax withholdings (such amount, the “Special Cash Payment”), for the remainder of the COBRA Premium Period. You may, but are not obligated to, use such
Special Cash Payments toward the cost of COBRA premiums. On the thirtieth (30th) day following your Separation from Service, the Company will make the first payment to you under this paragraph, in
a lump sum, equal to the aggregate Special Cash Payments that the Company would have paid to you through such date had the Special Cash Payments commenced on the first day of the first month following the Separation from Service through such
thirtieth (30th) day, with the balance of the Special Cash Payments paid thereafter on the schedule described above. 

3. CONSULTING AGREEMENT. If you timely sign this
Agreement and allow the releases contained herein to become effective, then the Company will engage you as a consultant under the terms set forth below. 

a. Consulting Period. You will initially serve as a consultant to the Company beginning on June 9, 2020, and
ending on December 31, 2020 (the “Initial Consulting Period”), unless terminated earlier pursuant to Section 3(j). Following the Initial Consulting Period, you will continue as a consultant to the Company on an as-needed basis until terminated pursuant to Section 3(j) (any period during which you are provided Consulting Services, including the Initial Consulting Period and thereafter, the “Consulting
Period”). 
 b. Consulting Services. As a consultant, you will be responsible for assisting the Company in
any area of your expertise, as reasonably requested by the Company (the “Consulting Services”). Among other things, you will assist the Company by providing advice related to business and corporate development as well as critical
historical subject matter expertise and perspective. It is anticipated that you will provide up to twenty (20) hours of Consulting Services per month during the Initial Consulting Period. Following the Initial Consulting Period, it is
anticipated that you will provide Consulting Services on an as-needed basis and at times that are mutually-agreed between you and the Company. You will exercise the highest degree of professionalism and
utilize your expertise and creative talents in performing the Consulting Services. You will conduct the Consulting Services at a location of your choosing. 

c. Consulting Fees. Provided that you: (i) perform the Consulting Services to the Company’s satisfaction (as
determined by the Company in its sole discretion); and (ii) comply with your contractual obligations to the Company (including, without limitation, the obligations set forth herein), then the Company will pay you consulting fees during the
Initial Consulting Period equal to $16,562.00 per month. The Company will pay you the monthly consulting fee within ten (10) business days after the end of each month. Following the Initial Consulting Period, the Company will pay you an hourly
consulting fee of $500 for any Consulting Services provided by you after the Initial Consulting Period. The hourly consulting fee will be paid to you within thirty (30) days of receipt by the Company of an invoice from you for such Consulting
Services. 

 Ken Song 

June 8, 2020 
 Page 
3
 of 11 
  

 d. Equity. During your employment with the Company, you were granted
options to purchase shares of the Company’s common stock (the “Options”). This Agreement is intended to commence in a manner such that you remain in “continuous service” with the Company after the Separation Date.
Thus, during the Initial Consulting Period, the vesting on your Options will remain unchanged, and will continue to vest as set forth in the governing equity agreements. However, notwithstanding anything to the contrary set forth in the option
agreements for your Options, vesting of your Options will cease as of the termination of the Initial Consulting Period. Your rights to exercise any vested Options shall be modified such that the exercisability of your Options shall terminate as of
the nine (9) month anniversary of the effective date of a Registration Statement on Form S-1 for the Company’s initial public offering of its Common Stock (“IPO”) if such effective
date occurs in 2020, or if an IPO does not occur in 2020 then, the exercisability of your Options shall terminate as of the earlier to occur of: (i) the nine (9) month anniversary of the date that the Company (or the parent company of the
Company) otherwise becomes subject to the reporting requirements of Sections 13 and 15(d) of the Securities Exchange Act of 1934, as amended; or (ii) the three month anniversary of the termination of the Consulting Period pursuant to
Section 3(j) hereof, provided that, if the Company unilaterally terminates the Consulting Period pursuant to Section 3(j) after the Initial Consulting Period, the date for this clause (ii) shall be the later of
(x) March 31, 2022 or (y) the three month anniversary of such termination. Except as set forth in this Agreement, the Options shall continue to be governed in all respects by the governing plan documents and agreements. You are
encouraged to obtain independent tax advice concerning your Options and how the terms of this Agreement may affect the tax treatment of the options. 

e. Tax Treatment. The Company will not make any withholdings or deductions, and will issue you a form 1099, with
respect to any consulting fees paid to you. You will be solely responsible for all taxes with respect to the consulting fees, and you agree to indemnify, hold harmless and defend the Company from any and all claims, liabilities, damages, taxes,
fines or penalties sought or recovered by any governmental entity, including but not limited to the Internal Revenue Service or any state taxing authority, arising out of or in connection with the consulting fees. 

f. Independent Contractor Status. You agree that during the Consulting Period: (i) you will be an independent
contractor to the Company and not an employee of the Company; and (ii) the Company will not make payments for state or federal income tax, FICA (social security and Medicare), make unemployment insurance or disability insurance contributions,
or obtain workers’ compensation insurance on your behalf. 
 g. Protection of Information. You agree that during
the Consulting Period and thereafter, you will not use or disclose any confidential or proprietary information or materials of the Company that you obtain or develop in the course of performing consulting services for the Company. Any and all work
product you create in the course of performing consulting services for the Company will be the sole and exclusive property of the Company. You hereby assign to the Company all right, title, and interest in all inventions, techniques, processes,
materials, and other intellectual property developed in the course of performing consulting services for the Company. 

 Ken Song 

June 8, 2020 
 Page 
4
 of 11 
  

 h. Limitations on Authority. You will have no responsibilities or
authority as a consultant to the Company other than as provided above. You agree not to represent or purport to represent the Company in any manner whatsoever to any third party except with my prior written consent. 

i. Standards of Conduct; Noncompetition; Nonsolicitation. You agree not to engage in any conduct during the Consulting
Period that is detrimental to the interests of the Company. You further agree during the Initial Consulting Period that you will not, directly or indirectly, as an officer, director, employee, consultant, owner, manager, member, partner, or in any
other capacity solicit, perform, or provide, or attempt to perform or provide Conflicting Services in the United States without prior authorization from the Company in writing, which will not be unreasonably withheld, nor will you assist another
person to solicit, perform or provide or attempt to perform or provide Conflicting Services in the United States without prior authorization from the Company in writing, which will not be unreasonably withheld. You and the Company agree that for
purposes of this Agreement, “Conflicting Services” means, as of the Separation Date, any product, service, or process or the research and development thereof, of any person or organization other than the Company that is
substantially similar to or competitive with a product, service, or process, including the research and development thereof, of the Company. Notwithstanding the above, you will not be deemed to be engaged directly or indirectly in any Conflicting
Services if you participate in any such business solely as a passive investor in up to two percent (2%) of the equity securities of a company or partnership, the securities of which are publicly traded. You agree further that, during the Initial
Consulting Period, you will not, either directly or through others, solicit or attempt to solicit any employee, independent contractor or consultant of the Company to terminate his or her relationship with the Company in order to become an employee,
consultant or independent contractor to or for any other person or entity. 
 j. Termination of Consulting Period.
During the Initial Consulting Period, (i) you many terminate the Consulting Period at any time and for any reason upon notice to the Company and (ii) the Company may terminate the Consulting Period for your material breach of this
Agreement or any other mutual agreement between you and the Company, provided that the Company shall provide you with thirty (30) days’ notice and an opportunity to cure such breach (if cure is possible). Following the Initial Consulting
Period, either you or the Company may terminate the Consulting Period, at any time and for any reason, upon fourteen (14) days’ written notice to the other party. Upon termination of the Consulting Period by either party, the Company will
have no further obligations to you, including any obligation to pay you further consulting fees. 
 4.
OTHER COMPENSATION OR BENEFITS. You acknowledge that, except as expressly provided in this Agreement, you will not receive any additional compensation, severance, or benefits
after the Separation Date. You further expressly acknowledge and agree that you are not entitled to any severance benefits from the Company under the terms of your employment agreement with the Company. 

5. EXPENSE REIMBURSEMENTS. You agree that, within ten
(10) days after the Separation Date, you will submit your final documented expense reimbursement statement 

 Ken Song 

June 8, 2020 
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reflecting all business expenses you incurred through the Separation Date, if any, for which you seek reimbursement. The Company will reimburse you for these expenses pursuant to its regular
business practice. 
 6. RETURN OF COMPANY
PROPERTY. Within five (5) days after the Separation Date, you agree to return to the Company all Company documents (and all copies thereof) and other Company property within your possession, custody or control,
including, but not limited to, Company files, notes, drawings, records, business plans and forecasts, financial information, specifications, computer-recorded information, tangible property (including, but not limited to), credit cards, entry cards,
identification badges, and keys; and, any materials of any kind that contain or embody any proprietary or confidential information of the Company (and all reproductions thereof); provided, however, that you are permitted to retain any
Company property that is necessary for the performance of your Consulting Services, and any such documents retained for that purpose must be returned to the Company by the close of business on the last date of the Consulting Period. Your timely
return of all such Company documents and other property is a condition precedent to your receipt of the benefits provided under this Agreement. 

7. PROPRIETARY INFORMATION OBLIGATIONS. Both during
and after your employment you acknowledge your continuing obligations under your Proprietary Information and Inventions Agreement, including your obligations not to use or disclose any confidential or proprietary information of the Company. A copy
of your Proprietary Information and Inventions Agreement is attached hereto as Exhibit A. 
 8.
CONFIDENTIALITY. The provisions of this Agreement will be held in strictest confidence by you and will not be publicized or disclosed in any manner whatsoever; provided, however, that: (a) you may
disclose this Agreement to your immediate family; (b) you may disclose this Agreement in confidence to your attorneys, accountants, auditors, tax preparers, and financial advisors; (c) you may disclose this Agreement, and any other
documents or information (without notice to the Company) when communicating with the Equal Employment Opportunity Commission, the Department of Labor, the National Labor Relations Board, the Occupational Safety and Health Administration, the
Securities and Exchange Commission or any other federal, state or local governmental agency or commission (“Government Agencies”), or during the course of an investigation or proceeding that may be conducted by any Government
Agency; (d) you may disclose this Agreement insofar as such disclosure may be necessary to enforce its terms or as otherwise required by law; and (e) you may disclose this Agreement as may be necessary to a third party that will compensate
you for services (e.g. a new employer). In particular, and without limitation, you agree not to disclose the terms of this Agreement to any current or former Company employee. Nothing in this provision or this Agreement is intended to prohibit or
restrain you in any manner from making disclosures that are protected under the whistleblower provisions of federal or state law or regulation. 

9. NONDISPARAGEMENT. You agree not to disparage the Company and its
officers, directors, employees, shareholders and agents, in any manner likely to be harmful to them or 

 Ken Song 

June 8, 2020 
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their business, business reputations or personal reputations; provided that you may respond accurately and fully to any question, inquiry or request for information when required by legal process
(e.g., a valid subpoena or other similar compulsion of law) or as part of a government investigation. In addition, nothing in this provision or this Agreement is intended to prohibit or restrain you in any manner from making disclosures that are
protected under the whistleblower provisions of federal or state law or regulation. 
 10. NO
VOLUNTARY ADVERSE ACTION; AND COOPERATION. You agree that you will not voluntarily provide assistance, information or advice, directly or
indirectly (including through agents or attorneys), to any person or entity in connection with any proposed or pending litigation, arbitration, administrative claim, cause of action, or other formal proceeding of any kind brought against the
Company, its parent or subsidiary entities, affiliates, officers, directors, employees or agents, nor shall you induce or encourage any person or entity to bring any such claims; provided that you may respond accurately and fully to any question,
inquiry or request for information when required by legal process (e.g., a valid subpoena or other similar compulsion of law) or as part of a government investigation. In addition, you agree to voluntarily cooperate with the Company if you have
knowledge of facts relevant to any existing or future litigation or arbitration initiated by or filed against the Company by making yourself reasonably available without further compensation for interviews with the Company or its legal counsel, for
preparing for and providing deposition testimony, and for preparing for and providing trial testimony. 
 11. IPO
LOCK-UP AGREEMENT. You agree to sign the lock-up agreement for the IPO and deliver such executed agreement concurrent
with the execution hereof and hereby agree to sign any amendment, termination, restatement, or extension of such agreement provided that the Company’s officers and directors have signed a substantially similar agreement for the benefit of the
underwriters for an IPO. 
 12. RELEASE OF CLAIMS. 

a. General Release. In exchange for the consideration provided to you under this Agreement to which you would not
otherwise be entitled, you hereby generally and completely release the Company, and its affiliated, related, parent and subsidiary entities, and its and their current and former directors, officers, employees, shareholders, partners, agents,
attorneys, predecessors, successors, insurers, affiliates, and assigns (collectively, the “Released Parties”) from any and all claims, liabilities and obligations, both known and unknown, that arise out of or are in any way related
to events, acts, conduct, or omissions occurring prior to or on the date you sign this Agreement (collectively, the “Released Claims”). 

b. Scope of Release. This general release includes, but is not limited to: (i) all claims arising out of or in any
way related to your employment with the Company or the termination of that employment; (ii) all claims related to your compensation or benefits from the Company, including salary, bonuses, commissions, vacation pay, expense reimbursements,
severance pay, fringe benefits, stock, stock options or any other ownership interests in the 

 Ken Song 

June 8, 2020 
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Company; (iii) all claims for breach of contract, wrongful termination or breach of the implied covenant of good faith and fair dealing; (iv) all tort claims, including claims for
fraud, defamation, emotional distress and discharge in violation of public policy; and (v) all federal, state, and local statutory claims, including claims for discrimination, harassment, retaliation, attorneys’ fees, or other claims
arising under the federal Civil Rights Act of 1964 (as amended), the federal Americans with Disabilities Act of 1990, the Families First Coronavirus Response Act, the California Labor Code (as amended), or the California Fair Employment and Housing
Act (as amended). 
 c. ADEA Waiver. You acknowledge that you are knowingly and voluntarily waiving and releasing any
rights you may have under the ADEA, and that the consideration given for the waiver and releases you have given in this Agreement is in addition to anything of value to which you were already entitled. You further acknowledge that you have been
advised, as required by the ADEA, that: (i) your waiver and release does not apply to any rights or claims that may arise after the date you sign this Agreement; (ii) you should consult with an attorney prior to signing this Agreement
(although you may choose voluntarily not to do so); (iii) you have twenty-one (21) days to consider this Agreement (although you may choose voluntarily to sign it sooner); (iv) you have seven
(7) days following the date you sign this Agreement to revoke this Agreement (in a written revocation sent to me); and (v) this Agreement will not be effective until the date upon which the revocation period has expired, which will be the
eighth day after you sign this Agreement provided that you do not revoke it. 
 d. Section 1542
Waiver. YOU UNDERSTAND THAT THIS AGREEMENT INCLUDES A RELEASE OF ALL KNOWN AND UNKNOWN CLAIMS. In giving the release herein, which includes claims which may be unknown to you at present, you acknowledge that you have read and understand
Section 1542 of the California Civil Code, which reads as follows: “A general release does not extend to claims that the creditor or releasing party does not know or suspect to exist in his or her favor at the time of executing the
release and that, if known by him or her, would have materially affected his or her settlement with the debtor or released party.” You hereby expressly waive and relinquish all rights and benefits under that section and any law of any other
jurisdiction of similar effect with respect to your release of any unknown or unsuspected claims herein. 
 e. Excluded
Claims. Notwithstanding the foregoing, the following are not included in the Released Claims (the “Excluded Claims”): (i) any rights or claims for indemnification you may have pursuant to any written indemnification
agreement with the Company to which you are a party or under applicable law; (ii) any rights which are not waivable as a matter of law; and (iii) any claims for breach of this Agreement. You hereby represent and warrant that, other than
the Excluded Claims, you are not aware of any claims you have or might have against any of the Released Parties that are not included in the Released Claims. You understand that nothing in this Agreement limits your ability to file a charge or
complaint with any Government Agency. While this Agreement does not limit your right to receive an award for information provided to the Securities and Exchange Commission, you understand and agree that, to maximum extent permitted by law, you are
otherwise waiving any and all rights you may have 

 Ken Song 

June 8, 2020 
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to individual relief based on any claims that you have released and any rights you have waived by signing this Agreement. 

13. REPRESENTATIONS. You hereby represent that you have been paid all compensation owed and for
all hours worked, have received all the leave and leave benefits and protections for which you are eligible pursuant to the Family and Medical Leave Act, the California Family Rights Act, or otherwise, and have not suffered any on-the-job injury for which you have not already filed a workers’ compensation claim. 

14. DISPUTE RESOLUTION. To ensure the timely and
economical resolution of disputes that may arise in connection with your employment with the Company, you and the Company agree that any and all disputes, claims, or causes of action arising from or relating to the enforcement, breach, performance,
negotiation, execution, or interpretation of this Agreement, your employment, or the termination of your employment, and your engagement as a consultant or termination of your engagement as a consultant, including but not limited to statutory
claims, shall be resolved pursuant to the Federal Arbitration Act, 9 U.S.C. §1-16, and to the fullest extent permitted by law by final, binding and confidential arbitration, by a single arbitrator,
conducted by JAMS, Inc. (“JAMS”) under the then applicable JAMS rules (which can be found at the following web address: https://www.jamsadr.com/rules-employment-arbitration/). By agreeing to this arbitration procedure, both you
and the Company waive the right to resolve any such dispute through a trial by jury or judge or administrative proceeding. The Company acknowledges that you will have the right to be represented by legal counsel at any arbitration proceeding. In
addition, all claims, disputes, or causes of action under this paragraph, whether by you or the Company, must be brought in an individual capacity, and shall not be brought as a plaintiff (or claimant) or class member in any purported class or
representative proceeding, nor joined or consolidated with the claims of any other person or entity. The arbitrator may not consolidate the claims of more than one person or entity, and may not preside over any form of representative or class
proceeding. To the extent that the preceding sentences regarding class claims or proceedings are found to violate applicable law or are otherwise found unenforceable, any claim(s) alleged or brought on behalf of a class shall proceed in a court of
law rather than by arbitration. This paragraph shall not apply to an action or claim brought in court pursuant to the California Private Attorneys General Act of 2004, as amended. The arbitrator shall: (a) have the authority to compel
adequate discovery for the resolution of the dispute and to award such relief as would otherwise be permitted by law; and (b) issue a written arbitration decision, to include the arbitrator’s essential findings and conclusions and a
statement of the award. The arbitrator shall be authorized to award any or all remedies that you or the Company would be entitled to seek in a court of law. The Company shall pay all JAMS’ arbitration fees in excess of the amount of court
fees that would be required of you if the dispute were decided in a court of law. Nothing in this Agreement is intended to prevent either you or the Company from obtaining injunctive relief in court to prevent irreparable harm pending the conclusion
of any such arbitration. Any awards or orders in such arbitrations may be entered and enforced as judgments in the federal and state courts of any competent jurisdiction. 

 Ken Song 

June 8, 2020 
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 15. MISCELLANEOUS.
This Agreement, including its exhibits, constitutes the complete, final and exclusive embodiment of the entire agreement between you and the Company with regard to the subject matter hereof. It is entered into without reliance on any promise or
representation, written or oral, other than those expressly contained herein, and it supersedes any other agreements, promises, warranties or representations concerning its subject matter. This Agreement may not be modified or amended except in a
writing signed by both you and a duly authorized officer of the Company. This Agreement will bind the heirs, personal representatives, successors and assigns of both you and the Company, and inure to the benefit of both you and the Company, their
heirs, successors and assigns. If any provision of this Agreement is determined to be invalid or unenforceable, in whole or in part, this determination shall not affect any other provision of this Agreement and the provision in question shall be
modified so as to be rendered enforceable in a manner consistent with the intent of the parties insofar as possible under applicable law. This Agreement shall be construed and enforced in accordance with the laws of the State of California without
regard to conflicts of law principles. Any ambiguity in this Agreement shall not be construed against either party as the drafter. Any waiver of a breach of this Agreement, or rights hereunder, shall be in writing and shall not be deemed to be a
waiver of any successive breach or rights hereunder. This Agreement may be executed in counterparts which shall be deemed to be part of one original, and facsimile and signatures transmitted by PDF shall be equivalent to original signatures. 

16. NO ADMISSIONS. You understand and agree that the promises and payments in
consideration of this Agreement shall not be construed to be an admission of any liability or obligation by the Company to you or to any other person, and that the Company makes no such admission 

[Signature Page Follows] 

 Ken Song 

June 8, 2020 
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 If this Agreement is acceptable to you, please sign below and return the
original to me within twenty-one (21) days. The Company’s offer contained herein will automatically expire if we do not receive the fully signed Agreement within this timeframe. 

We wish you the best in your future endeavors. 

Sincerely, 

METACRINE, INC. 
  

			
	 By:
	 	 /s/ Richard A. Heyman

		 	 Richard A. Heyman, Chairman of the Board

 Exhibit A – Proprietary Information and Inventions Agreement 

I HAVE READ, UNDERSTAND AND AGREE FULLY
TO THE FOREGOING AGREEMENT: 
  

					
	 /s/ Ken Song
	 		 	 June 8, 2020

	 Ken Song, M.D.
	 		 	 Date

 EXHIBIT A 

PROPRIETARY INFORMATION AND INVENTIONS AGREEMENTEX-10.11

 Exhibit 10.11 

 
 

 
 March 5, 2018 

Trisha Millican 
 VIA email

 Trisha, 

I am delighted to make you an offer of employment for the position of Chief Financial Officer (CFO) at Metacrine Inc. (the
Company), reporting to Ken Song. The effective date of your employment will be based on a mutually acceptable date but no later than April 1, 2018. The terms of the offer are as follows: 

Duties and Extent of Service 

As full-time CFO for the Company, you will have responsibility for performing those duties as are customary for, and are
consistent with, such position, as well as those duties as may be assigned to you from time to time. If you join the Company, you agree to abide by the rules, regulations, instructions, personnel practices and policies of the Company and any changes
therein which may be adopted from time to time by the Company. Except for vacations and absences due to temporary illness, you will be expected to devote all of your business time and effort to the business and affairs of the Company. 

Base Salary 

The Company will pay you a base salary of 300,000 dollars per year, paid semimonthly, less payroll deductions, required taxes,
withholdings and payable in accordance with the Company’s standard payroll practices. 
 Benefits 

As a Company employee, your eligibility to participate in the Company employee benefit plans and fringe benefits will depend on
whether you meet the eligibility terms of the applicable plans. In addition, you will be eligible to receive up to 30% of your annual salary in the form of a performance bonus each year, subject to approval of a bonus plan by the board of directors
and in accordance with the terms of such approved plan. 
 Stock Options 

In addition, if you decide to join the Company, it will be recommended to the Company’s Board of Directors following your
start date that the Company grant you an option to purchase approximately 360,000 shares of the Company’s common stock at a price per share equal to the fair 

  
 METACRINE, INC. 

12780 EL CAMINO REAL, SUITE 301 

SAN DIEGO, CA 92130 

 
market value per share of the Common Stock on the date of grant, as determined by the Company’s Board of Directors. 25% of the shares subject to the option shall vest 12 months after the
date your vesting begins subject to your continuing employment with the Company, and no shares shall vest before such date. The remaining shares shall vest monthly over the next 36 months in equal monthly amounts subject to your continuing
employment with the Company. This option grant will be subject to the terms and conditions of the Company’s equity incentive plan and stock option agreement, including vesting requirements. No right to any stock is earned or accrued until such
time that vesting occurs, nor does the grant confer any right to continue vesting or employment. 
 Nondisclosure and Developments

 The Company has extended this offer to you based upon your general knowledge, background, experience and skills and
abilities and not because of your knowledge of your current employer’s or any previous employer’s trade secrets or other confidential information. As a condition of employment at the Company, you will be required to sign the Company’s
standard At-Will Employment, Confidential Information, Invention Assignment and Arbitration Agreement in which you agree to, among other things, not disclose to the Company or use in your employment with the
Company any confidential or proprietary information or trade secrets of any current or prior employer. In this regard, you should be extremely careful not to bring to the Company any documents or other materials in tangible form belonging to or
acquired from any current or prior employer. 
 At-Will Employment 

This Agreement is not a contract of employment for any specific or minimum term and that the employment the Company offers you
is terminable at will. This means that our employment relationship is voluntary and based on mutual consent. You may resign your employment, and the Company likewise may terminate your employment, at any time, for any reason, with or without cause
or notice. Any prior oral or written representations to the contrary are void, and any future representations to the contrary are also void and should not be relied upon unless they are contained in a formal written employment contract signed by an
officer of the Company and expressly stating the company’s intent to modify the at-will nature of your employment. 

Governing Law 

This Agreement shall be governed by and construed in accordance with the internal substantive laws of the State of California.

 Background Checks; Eligibility to Work in the United States 

The Company reserves the right to conduct background investigations and/or reference checks on all of its potential employees.
Your job offer, therefore, is contingent upon a clearance of such a background investigation and/or reference check, if any. 

  
 METACRINE, INC. 

12780 EL CAMINO REAL, SUITE 301 

SAN DIEGO, CA 92130 

 For purposes of federal immigration law, you will be required to provide to
the Company documentary evidence of your identity and eligibility for employment in the United States. Such documentation must be provided to the Company within three (3) business days of your commencement date, or our employment relationship
with you may be terminated. 
 Entire Agreement: Amendment 

This Agreement will constitute the entire agreement and understanding between the Company and you with respect to the specific
matters contemplated and addressed hereby. No prior agreement between you and the Company, whether written or oral, shall be construed to change or affect the operation of this Agreement in accordance with its terms, and any provision of any such
prior agreement which conflicts with or contradicts any provision of this Agreement is hereby revoked and superseded. 

This Agreement may be amended or modified only by a written instrument executed both by you and the Company. If any portion of
this Agreement shall, for any reason, be held invalid or unenforceable, or contrary to public policy or any law, the remainder of this Agreement shall not be affected by such invalidity or unenforceability, but shall remain in full force and effect
as if the invalid or unenforceable term or portion thereof had not existed within this Agreement. 
 This Agreement will
expire if not accepted by March 9, 2018. 
 We are excited to have you on the team! 

 

	
	 Sincerely,

	
	 /s/ Ken Song

	
	 Ken Song

	 President & Chief Executive Officer

  

			
	 Accepted By: /s/ Trisha Millican

	
	 Print Name Trisha Millican

	
	 Date March 6, 2018

  
 METACRINE, INC. 

12780 EL CAMINO REAL, SUITE 301 

SAN DIEGO, CA 92130

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