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Exhibit 10.55    
    

	 	 	Millennium Pharmaceuticals, Inc.

238 Main Street

Cambridge, MA 02142

Tel 617 679 7000

www.mlnm.com

        [Millennium
logo] 

June 11,
1999 

Joseph
B. Bolen, Ph.D.

15 Hallview Drive

Simsbury, CT 06070 

Dear
Joe, 

        On
behalf of Millennium Pharmaceuticals, Inc. (the "Company"), I am pleased to offer you the position of Vice President, Oncology in the Research group reporting to Bob Tepper,
Chief Scientific Officer. 

        1.    Job Responsibilities:    Your job responsibilities in this position will include the following: 

	•
	As
the leader of Oncology at Millennium Pharmaceuticals, oversee all of the research activities in the therapeutic area within the Company and serve as the key liaison with
pharmaceutical partners.

	•
	Coordinate
and further develop the drug discovery efforts in Oncology within Millennium and with pharmaceutical products.

	•
	Working
with the CSO, develop a plan for broadening the research and development activities in the therapeutic area of oncology, including the development of new alliances.

	•
	Serve
as the head of the cross company team in Oncology, which coordinates the R&D efforts in cancer between Millennium Pharmaceuticals, Inc. and its two
subsidiaries, Millennium Biotherapeutics and Millennium Predictive Medicine.

	•
	Develop
a state-of-the art biochemistry and cell biology laboratory within the research division through external hires and internal reorganization
of existing personnel.

	•
	Provide
leadership across therapeutic areas in signal transduction mechanisms for the development of novel therapeutic targets.

	•
	Serve
as a key member of the senior management team in the pharmaceutical research division.

	•
	Develop
strong working relationships with other groups in the Company to ensure teamwork on all projects.

	•
	Actively
participate in recruiting only the best scientific and management team for Millennium. 

        2.    Effective Date:    The effective date of your full-time employment with the Company is to be on or
about Monday, August 2, 1999. 

        3.    Salary:    Your base salary will initially be $260,000 per annum. Your salary will be paid periodically in
accordance with the Company's payroll procedures. In addition, in accordance with the Company's compensation practices, you will receive, approximately annually, a salary review which will 

 

be
based on your performance, the Company's performance and such other factors as may be determined by the Company's Board of Directors. 

        4.    Benefits:    You and your dependents will be eligible for the Company's standard medical, dental, life
insurance, disability benefits and Section 125 cafeteria plan. After the standard waiting periods, you will also be eligible to participate in the Company's 401(k) and Employee Stock Purchase
plans. You will accrue vacation at the rate of 1.25 days per month of full-time employment. Standard paid holidays will be observed. Transportation benefits, including a choice of
MBTA pass up to $60 or contributory off-site parking, are also available. The Company, however, reserves the right to modify its employee benefit programs from
time-to-time. 

        5.    Equity Participation, Vesting of Stock:    Subject to approval by the Company's Board of Directors, you will be
granted an incentive stock option exercisable for 75,000 shares of the Company's Common Stock at an exercise price equal to the current fair market value of the Company's Common Stock as determined by
the Company's Board of Directors. This option will vest as to one fourth (1/4) of the shares on the first anniversary of your commencement of full-time employment with the
Company and as to one forty-eighth (1/48) of the shares at the end of each full month thereafter until all shares are vested, provided that you remain employed by the Company. In the
event of your death or total and permanent disability (as defined in the Internal Revenue Code of 1986, as amended) during the first year of your employment, the initial one-fourth
(1/4) of your shares that would have vested at the end of your first year of employment shall vest. In the event of termination of your employment for any reason (except as set forth in
the preceding sentence), vesting shall cease. Please refer to the Company's Incentive Stock Plan for complete details. 

        6.    Employment Period:    Your employment with the Company will be at-will, meaning that you will not be
obligated to remain employed by the Company for any specified period of time; likewise, the Company will not be obligated to continue your employment for any specific period and may terminate your
employment at any time, with or without cause. 

        7.    Employment Eligibility Verification:    Please note that all persons employed in the United States, are required
to complete an Employment Eligibility Verification Form on the first day of employment and submit an original document or documents that establish identity and employment eligibility within three
business days of employment. For your convenience, we are enclosing Form I-9 for your review. You will need to complete Section 1 and present original document(s) of your
choice as listed on the reverse side of the form once you begin work. 

        8.    Proprietary Information, No Conflicts:    You agree to execute the Company's standard form of Invention,
Non-Disclosure and Non-Competition Agreement and to be bound by all of the provisions thereof. You hereby represent that you are not presently bound by any employment
agreement, confidential or proprietary information agreement or similar agreement with any current or previous employer that would impose any restriction on your acceptance of this offer or that would
interfere with your ability to fulfill the responsibilities of your position with the Company. 

        9.    Medical Surveillance:    As part of Millennium's medical surveillance program, employees are required to have an
initial physical, provided by an on-site registered nurse. All laboratory employees working with hazardous chemical, infectious agents, radio labeled materials or animals shall have access
to medical attention, including initial and periodic medical exams without cost to the employee or loss of pay. An employee may refuse an exam if he/she signs a release. If you want to decline from
having the initial physical, please notify Human Resources on your first day at New Employee Orientation. Your initial surveillance examination will be scheduled to take place during the first week of
your employment. 

        10.    New Employee Orientation:    On the first Monday of your employment with the Company, you should arrive at our
75 Sidney Street at location for New Employee Orientation. Millennium is located 

2

 

at
University Park at 75 Sidney Street on the 2nd floor. If taking the MBTA you will get off at the Central Square stop on the Red Line. Directions for driving are enclosed. Millennium will
reimburse you for any parking expenses. Orientation will begin promptly at 8:30 a.m. 

        11.    Sign-on Bonus:    The Company will pay you a bonus of $25,000 on the date of the first paycheck
following commencement of your full time employment. Should you terminate for any reason within 12 months of your starting date after having received your bonus, the Company reserves the right
to seek repayment of all or a pro-rata portion of your bonus. An additional bonus of $25,000 will be paid with the paycheck next following the one year anniversary of the commencement
of your full-time employment. The Company reserves the right to seek repayment of a pro-rata portion of this bonus should you terminate for any reason during the following
12 months. 

        12.    Relocation Expenses:    Upon your acceptance of this offer, you are eligible for reimbursement of the following
expenses associated with your relocation: 

	•
	Reimbursement
for expenses associated with direct-route transportation to Cambridge.

	•
	The
cost of packing, moving, 60 days' temporary storage, and unloading of your household goods and effects using a certified carrier of the Company's choice.

	•
	Temporary
housing for up to two months upon your arrival in the Boston area.

	•
	Destination
services provided by Corporate Real Estate Services, a division of Hunneman Coldwell Banker.

	•
	Closing
costs (excluding points) on the purchase of a new home, if purchased within 12 months of your date of hire.

	•
	The
Company will provide a lump sum allowance of $2,000 (grossed up) to cover additional relocation related expenses. This sum will be paid to you on the date of your first
paycheck following commencement of your full time employment. Should you voluntarily resign from the Company within one year of relocating, the Company reserves the right to seek repayment of the
entire amount. 

        Joe,
all of us here at Millennium are very enthusiastic about your commitment to joining the Company and have the highest expectation of your future contributions. 

        Please
indicate your acceptance of the foregoing by signing the enclosed copy of this letter and returning it to the Company no later than June 21, 1999. After that date, the
offer will lapse. 

Very
truly yours,

MILLENNIUM PHARMACEUTICALS, INC. 

	/s/  LINDA K. PINE      
 LINDA K. PINE

Sr. Vice President, Human Resources	 	 
	

The foregoing is signed and accepted as of the date first above written by:
	

/s/  JOSEPH B. BOLEN      
 Josepn B. Bolen	
 	

June 13, 1999
 Date

3

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Exhibit 10.56    
    

	 	 	Millennium Pharmaceuticals, Inc.

75 Sidney Street

Cambridge, MA 02139

Tel 617 679 7000

www.mlnm.com

        [Millennium
logo] 

August 29,
2001 

Nancy
Simonian, M.D.

61 Old Sudbury Road

Wayland, Ma 01778 

Dear
Nancy, 

        On
behalf of Millennium Pharmaceuticals, Inc. (the "Company"), I am pleased to offer you the position of Vice President in the Clinical Development group reporting to Mark Levin,
CEO. 

        1.    Effective Date:    The effective date of your full-time employment with the Company is to be
determined upon your formal acceptance of this offer. After discussion with the hiring manager, please contact Shana Stevens at 617-551-7889 to confirm your start date. 

        2.    Salary:    Your base salary will initially be $250,000 per annum. Your salary will be paid periodically in
accordance with the Company's payroll procedures. In addition, in accordance with the Company's compensation practices, you will receive, approximately annually, a salary review which will be based on
your performance, the Company's performance and such other factors as may be determined by the Company's Board of Directors. 

        3.    Success Sharing:    You will be eligible to participate in the Millennium Success Sharing cash bonus program,
which includes a fixed percentage of salary target for each position, prorated for length of active service in the calendar year. The funding of the target is based on the Company meeting overall
goals established at the beginning of each calendar year. In the event of Company performance below or above target, your personal bonus target may vary. Your individual bonus payment will also vary
based on your individual performance. The target for your position is 25% of your annual salary. Your manager will work with you to establish your individual goals, which will be the primary factor in
determining your bonus payment. Bonus payments will be made to eligible and active employees in March of 2002 for the 2001 Success Sharing Plan. 

        4.    Benefits:    You and your dependents will be eligible for the Company's standard medical, dental, life
insurance, disability benefits and Section 125 cafeteria plan. After the standard waiting periods, you will also be eligible to participate in the Company's 401(k) and Employee Stock Purchase
plans. You will accrue vacation at the rate of 1.25 days per month of full-time employment. Standard paid holidays will be observed. Transportation benefits, including a choice of
MBTA pass up to $60 or contributory off-site parking, are also available. The Company, however, reserves the right to modify its employee benefit programs from
time-to-time. 

        5.    Equity Participation, Vesting of Stock:    Subject to approval by the Company's Board of Directors, you will be
granted stock options exercisable for 60,000 shares of the Company's Common Stock. One third (1/3) of the total number of stock options will be granted on the last day of the calendar
month in which you commence full-time employment with the Company, and one third will be granted on the last day of each of the next two succeeding calendar months. The exercise price of
these 

 

stock
options will be equal to the fair market value of Millennium's Common Stock on the date of each grant. All options will vest as to one fourth (1/4) of the shares on the first
anniversary of your commencement of full-time employment with the Company and as to one forty-eighth (1/48) of the shares monthly thereafter until all shares are vested,
provided that you remain employed by the Company. In the event of your death, all options will vest immediately as to all shares. In the event of termination of your employment for any reason (except
as set forth in the preceding sentence), vesting as to all shares shall cease. Provided that you remain employed by the Company, these stock options will be exercisable (as to the vested portion) for
10 years from the date of each grant. A complete description of the terms and conditions of these stock options are contained in the Company's 2000 Stock Incentive Plan or will be contained in
your stock option grant forms. 

        6.    Employment Period:    Your employment with the Company will be at-will, meaning that you will not be
obligated to remain employed by the Company for any specified period of time; likewise, the Company will not be obligated to continue your employment for any specific period and may terminate your
employment at any time, with or without cause. 

        7.    Employment Eligibility Verification:    Please note that all persons employed in the United States, are required
to complete an Employment Eligibility Verification Form on the first day of employment and submit an original document or documents that establish identity and employment eligibility within three
business days of employment. For your convenience, we are enclosing Form I-9 for your review. You will need to complete Section 1 and present original document(s) of your
choice as listed on the reverse side of the form once you begin work. Please note: the I-9 form and valid identification are legal  requirements and must be submitted
within 3 days of your start date. If you do not submit the required documentation
within the 3-day time frame, by law we cannot allow you to continue to work.  

        8.    Proprietary Information, No Conflicts:    You agree to execute the Company's standard
form of Invention, Non-Disclosure and Non-Competition Agreement and to be bound by all of the provisions thereof. You hereby represent that you are not presently bound by any
employment agreement, confidential or proprietary information agreement or similar agreement with any current or previous employer that would impose any restriction on your acceptance of this offer or
that would interfere with your ability to fulfill the responsibilities of your position with the Company. 

        9.    Medical Surveillance:    As part of Millennium's medical surveillance program, employees are required to have an
initial physical, provided by an on-site registered nurse. All laboratory employees working with hazardous chemical, infectious agents, radio labeled materials or animals shall have access
to medical attention, including initial and periodic medical exams without cost to the employee or loss of pay. An employee may refuse an exam if he/she signs a release. If you want to decline from
having the initial physical, please notify Human Resources on your first day at New Employee Orientation. Your initial surveillance examination will be scheduled to take place during the first week of
your employment. 

        10.    New Employee Orientation:    On the first Monday of your employment with the Company, you should arrive at our
75 Sidney Street at location for New Employee Orientation. Millennium is located at University Park at 75 Sidney Street, and orientation is held on the 1st floor. If taking the MBTA you will
get off at the Central Square stop on the Red Line. Directions for driving are enclosed. Millennium will reimburse you for any parking expenses. Orientation will begin promptly at 8:30 a.m. 

        11.    Sign-on Bonus:    The Company will pay you a bonus of $60,000 on the date of the first paycheck
following commencement of your full time employment. Should you terminate for any reason within 12 months of your starting date after having received your bonus, the Company reserves the right
to seek repayment of all or a pro-rata portion of your bonus. 

2

 

        Nancy,
all of us here at Millennium are very enthusiastic about you commitment to joining the Company and have the highest expectation of your future contributions. 

        Please
indicate your acceptance of the foregoing by signing the enclosed copy of this letter and returning it to Pam Torto no later than
September 7, 2001. After that date, the offer will lapse. 

Very
truly yours,

MILLENNIUM PHARMACEUTICALS, INC. 

	/s/  LINDA K. PINE      
 LINDA K. PINE

Sr. Vice President, Human Resources	 	 
	

The foregoing is signed and accepted as of the date first above written by:
	

/s/  NANCY SIMONIAN      
 Nancy Simonian, M.D.	
 	

9/19/01
 Date

3

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Exhibit 10.56

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