Document:

Exhibit 10.22

 

Exhibit 10.22

Outside Director Compensation Plan(a)

	 	 	 
	Annual Cash Retainer:
	 	 
	Board Member

	 	$30,000
	 
	Audit Committee Chair

	 	$10,000
	Audit Committee Member

	 	No additional compensation

	Compensation Committee Chair

	 	$10,000
	Compensation Committee Member

	 	No additional compensation

	Nominating Committee Chair

	 	No additional compensation

	Nominating Committee Member

	 	No additional compensation

	 
	 	 
	Additional Payments:
	 	 
	Attendance Fee for In Person Attendance at Board Meeting

	 	$1,000
	Attendance Fee for Telephone Attendance at Board Meeting

	 	 $500
	Attendance Fee for Committee Meeting Attendance

	 	$500
	 
	 	 
	One-Time Option Grant
	 	 
	New directors — on date of initial election to Board

	 	None

	 
	 	 
	Annual Stock Option Grant(b)

	 	$80,000
	 
	 	 
	Annual Grant of Restricted Stock(c)

	 	$30,000
	 
	 	 
	Expense Reimbursement — for travel, lodging and other reasonable out-of-pocket
     expenses incurred in attending board and committee meetings

 

			
	All amounts listed above are in U.S. dollars.
	 
	(a)	 	Each member of the Board, other than those who are employees of the Company, is eligible
under the plan.
	 
	(b)	 	Each of these options will have an exercise price equal to the fair market value of the
Company’s common stock on the date of grant and will vest 25% per year on each anniversary of
the option grant date for 4 years.
	 
	(c)	 	Each share of restricted stock will fully vest on the first anniversary of the grant date.

Amount of shares issued for stock grants will equal to amount of stock award divided by the per
share 123R charge as determined by the company for financial reporting purposes.

Timing of
Director Compensation:

Each Director shall receive an initial stock option grant and
restricted stock award the day of Lululemon’s prospective IPO.
Thereafter, each Director will receive their annual stock option
grant and restricted stock award on the date of the Company’s
annual meeting. The cash retainer fees will be paid in arrears,
quarterly or semi-annually at the Company’s discretion.Exhibit 10.2 

	C
        L I F F O R D

    C H A N C E	
CLIFFORD CHANCE LLP        
	 
	
EXECUTION COPY  

	
US$2,300,000,000  
	 
	
FACILITIES AGREEMENT  
	 
	
dated 20 February 2007  
	 
	
for  
	 
	
SHIRE PLC  
	 
	
arranged by  
	 
	
ABN AMRO BANK N.V.  
	
BARCLAYS CAPITAL  
	
CITIGROUP GLOBAL MARKETS LIMITED  
	
THE ROYAL BANK OF SCOTLAND PLC  
	 
	
with  
	 
	
BARCLAYS BANK PLC  
	
acting as Facility Agent  
	
acting as Euro Swingline Agent  
	
acting as Dollar Swingline Agent  
	 
	

  
	        
	
MULTICURRENCY TERM AND REVOLVING FACILITIES  
	
AGREEMENT  
	 
	

CONTENTS

	 	 	 	 	 
	
CLAUSE  	     	
Page    
	 	 	 	 	 
	
1.  	
  	
Definitions and Interpretations  	     	
1  
	
2.  	
  	
The Facilities  	     	
21  
	
3.  	
  	
Purpose  	     	
21  
	
4.  	
  	
Conditions of Utilisation  	     	
22  
	
5.  	
  	
Utilisation - Procedure  	     	
25  
	
6.  	
  	
Utilisation - Swingline Loans  	     	
26  
	
7.  	
  	
Swingline Loans  	     	
31  
	
8.  	
  	
Selection of currencies  	     	
34  
	
9.  	
  	
Amount of optional currencies  	     	
35  
	
10.  	
  	
Repayment  	     	
36  
	
11.  	
  	
Illegality, Voluntary Prepayment and cancellation  	     	
36  
	
12.  	
  	
Mandatory Prepayment  	     	
38  
	
13.  	
  	
Restrictions  	     	
39  
	
14.  	
  	
Extension of Facility B  	     	
40  
	
15.  	
  	
Interest  	     	
41  
	
16.  	
  	
Interest Periods  	     	
42  
	
17.  	
  	
Changes to the calculation of interest  	     	
42  
	
18.  	
  	
Fees  	     	
43  
	
19.  	
  	
Tax Gross Up and Indemnities  	     	
45  
	
20.  	
  	
Increased costs  	     	
50  
	
21.  	
  	
Other indemnities  	     	
51  
	
22.  	
  	
Mitigation by the Lenders  	     	
53  
	
23.  	
  	
Costs and expenses  	     	
53  
	
24.  	
  	
Guarantee and indemnity  	     	
55  
	
25.  	
  	
Representations  	     	
58  
	
26.  	
  	
Information undertakings  	     	
61  
	
27.  	
  	
Financial covenants  	     	
64  
	
28.  	
  	
General undertakings  	     	
70  
	
29.  	
  	
Events of Default  	     	
76  
	
30.  	
  	
Changes to the Lenders  	     	
81  
	
31.  	
  	
Changes to the Obligors  	     	
84  

	
32.  	
  	
Role of the Agent and the Arranger  	     	
87  
	
33.  	
  	
Conduct of business by the Finance Parties  	     	
92  
	
34.  	
  	
Sharing among the Finance parties  	     	
92  
	
35.  	
  	
Payment mechanics  	     	
94  
	
36.  	
  	
Set-off  	     	
96  
	
37.  	
  	
Notices  	     	
96  
	
38.  	
  	
Calculations and certificates  	     	
98  
	
39.  	
  	
Partial invalidity  	     	
98  
	
40.  	
  	
Remedies and waivers  	     	
99  
	
41.  	
  	
Amendments and waivers  	     	
99  
	
42.  	
  	
Counterparts  	     	
101  
	
43.  	
  	
Governing law  	     	
102  
	
44.  	
  	
Enforcement  	     	
102  

	SCHEDULE 1   	 	THE ORIGINAL PARTIES  	103  

	 	 	Part I The Original
          Obligors  	 	103  
	 	 	Part II The Original
          Term Lenders  	 	104  
	 	 	Part III The Original
          Revolving Lenders  	 	105  
	 	 	Part IV The Original
          Dollar Swingline Lenders  	 	106  
	 	 	Part V The Original
          Euro Swingline Lenders  	 	107  

	SCHEDULE 2   	 	CONDITIONS PRECEDENT  	108  

	 	 	Part I Conditions precedent
          to initial Utilisation  	 	108  
	 	 	Part II Conditions
          precedent to Certain Funds Utilisation  	 	110  
	 	 	Part III Conditions
          precedent required to be delivered by an Additional Obligor  	 	111  

	SCHEDULE 3  	 	REQUESTS 	113  

	 	 	Part I Utilisation
          Request - Term Loans and Revolving Loan  	 	113  
	 	 	Part II Utilisation
          Request - Swingline Loan  	 	115  

	SCHEDULE 4  	 	MANDATORY COST
        FORMULAE  	 	116  
	SCHEDULE 5  	 	FORM
        OF TRANSFER CERTIFICATE  	 	119  
	SCHEDULE 6  	 	FORM
        OF ACCESSION LETTER  	 	121  
	SCHEDULE 7  	 	FORM
        OF RESIGNATION LETTER  	 	122  
	SCHEDULE 8  	 	FORM
        OF COMPLIANCE CERTIFICATE  	 	123  
	SCHEDULE 9  	 	EXISTING SECURITY  	 	124  
	SCHEDULE 10  	 	EXISTING LOANS  	 	125  

	SCHEDULE 11  	 	EXISTING FINANCIAL INDEBTEDNESS  	 	126  
	SCHEDULE 12  	 	FORM
        OF CONFIDENTIALITY UNDERTAKING  	 	127  
	SCHEDULE 13  	 	TIMETABLES  	 	133  

THIS AGREEMENT is dated 20 February 2007 and made between:

	
(1)  	
SHIRE PLC (the "Company");  
	 
	
(2)  	
THE SUBSIDIARIES of the Company, together with the Company, listed in Part I of Schedule 1 (The Original Parties) as original borrowers (the "Original Borrowers");  
	 
	
(3)  	
SHIRE PLC (the "Original Guarantor");  
	 
	
(4)  	
ABN AMRO BANK N.V., BARCLAYS CAPITAL, CITIGROUP GLOBAL MARKETS LIMITED AND THE ROYAL BANK OF SCOTLAND PLC as mandated lead arrangers (whether acting individually or together, the
"Arrangers");  
	 
	
(5)  	
THE FINANCIAL INSTITUTIONS listed in Part II of Schedule 1 (The Original Parties) as term lenders (the
"Original Term Lenders");  
	 
	
(6)  	
THE FINANCIAL INSTITUTIONS listed in Part III of Schedule 1 (The Original Parties) as revolving lenders (the
"Original Revolving Lenders").  
	 
	
(7)  	
THE FINANCIAL INSTITUTIONS listed in Part IV of Schedule 1 (The Original Parties) as dollar swingline lenders
(the "Original Dollar Swingline Lenders");  
	 
	
(8)  	
THE FINANCIAL INSTITUTIONS listed in Part V of Schedule 1 (The Original Parties) as euro swingline lenders
(the "Original Euro Swingline Lenders");  
	 
	
(9)  	
BARCLAYS BANK PLC as facility agent of the other Finance Parties (in this capacity, the "Facility Agent");  
	 
	
(10)  	
BARCLAYS BANK PLC as euro swingline agent of the other Finance Parties (in this capacity, the "Euro Swingline Agent"); and  
	 
	
(11)  	
BARCLAYS BANK PLC as dollar swingline agent of the other Finance Parties (in this capacity, the "Dollar Swingline Agent").  

IT IS AGREED as follows:

SECTION 1

INTERPRETATION

	
1.  	
DEFINITIONS AND INTERPRETATIONS 
	 
	
1.1  	
Definitions     
	 	
In this Agreement:  
	 
	 	
"2005 Agreement" means the multicurrency revolving facilities agreement dated 15 June 2005 made between, among others, Shire Pharmaceuticals Group
Limited (formerly known as Shire Pharmaceuticals Group plc), ABN Amro Bank N.V., Barclays Capital, Citigroup Global Markets Limited, HSBC Bank plc and The Royal Bank of Scotland plc.  
	 
	 	
"Acceptance Date" shall have the meaning set out in the Acquisition Agreement.  

- 1 -

	 	"Accession
            Letter" means a document substantially
            in the form set out in Schedule 6 (Form
            of Accession Letter).

       "Acquisition" means
          the transaction pursuant to which a member of the Group becomes the
          owner of record of all of the issued share capital of New River by
          a two step merger (involving a tender offer followed by a merger). 

       "Acquisition
            Documents" means the Acquisition
            Agreement and the Offer Documents (as such term is defined in the
            Acquisition Agreement).

       "Acquisition
            Agreement" means the agreement
            of merger dated on or around the date of this Agreement between the
            Company, Shuttle Corporation and New River.

       "Acquisition
            Proceeds" means the proceeds
            of a claim (a "Recovery Claim")
            made by any member of the Group in relation to the Acquisition Document
    except for Excluded Acquisition Proceeds and after deducting:

	 	
(a)  	
any reasonable expenses or costs which are incurred by any member of the Group to persons who are not members of the Group; and  
	 
	 	
(b)  	
any Tax incurred and required to be paid by a member of the Group in connection with such claim (as reasonably determined by the relevant member of the Group on the basis of existing rates taking into account any available
credit, deduction or allowance),  

	 	 
	 	in each case to be reimbursed out of such Recovery
    Claim.
	 	 
	 	 "Acquisition
          Purpose" means any of the purposes
          set out in sub-clause 3.1.1 and subclauses 3.1.2(a) and (d) of Clause
    3.1 (Purpose).
	 	 
	 	"Additional
          Borrower" means a company which
          becomes an Additional Borrower in accordance with Clause 31 (Changes
    to the Obligors).
	 	 
	 	 "Additional
          Cost Rate" has the meaning given
          to it in Schedule 4 (Mandatory
    Cost formulae).
	 	 
	 	 "Additional
          Guarantor" means a company which
          becomes an Additional Guarantor in accordance with Clause 31 (Changes
    to the Obligors).
	 	 
	 	 "Additional
          Obligor" means an Additional Borrower
    or an Additional Guarantor.
	 	 
	 	 "Affiliate" means,
        in relation to any person, a Subsidiary of that person or a Holding Company
    of that person or any other Subsidiary of that Holding Company.
	 	 
	 	"Agents" means
        the Dollar Swingline Agent, the Euro Swingline Agent, the Agent and the
        Facility Agent, and "Agent" means, as the context
    may require, any of them. 
	 	 
	 	 "New River Convertible Bond" means
        the 3.5 per cent convertible subordinated notes due 2013, issued by New
    River.

- 2 -

	 	 "Authorisation" means
        an authorisation, consent, approval, resolution, licence, exemption,
        filing, notarisation or registration.

     "Availability
    Period" means:

	 	 	 
	 	
(a)  	
in relation to Facility A, the period from and including the date of this Agreement to and including the date which is the earlier of (i) 9 Months after the date of this Agreement and (ii) 4 Months after the Walk-Away Date;
and  
	 
	 	
(b)  	
in relation to Facility B, the period from and including the date of this Agreement to and including the date which is the earlier of (i) 9 Months after the date of this Agreement and (ii) 4 Months after the Walk-Away Date;
and  
	 
	 	
(c)  	
in relation to the Revolving Facility, the period from and including the date of this Agreement to the date which is one week prior to the Revolving Facility Maturity Date.  
	 	 	 
	 	"Available
        Commitment" means a Lender's Commitment
    minus:  
	 	 	 
	 	(a)  	the Base Currency Amount of its participation
      in any outstanding Loans; and  
	 	 	 
	 	(b)  	in relation to any proposed Utilisation, the
      Base Currency Amount of its participation in any Loans that are due to
      be made under that Facility on or before the proposed Utilisation Date,  
	 	 	 
	 	other
        than, in either case, a Revolving Lender's participation in any Revolving
        Loans that are due to be repaid or prepaid on or before the proposed
        Utilisation Date.

     "Available
          Facility" means, in relation to
          a Facility, the aggregate for the time being of each Lender's Available
          Commitment in respect of that Facility.

     "Base
          Currency" means US Dollars.

     "Base
          Currency Amount" means, in relation
          to a Loan, the amount specified in the Utilisation Request delivered
          by a Borrower (or the Company on behalf of a Borrower) for that Loan
          (or, if the amount requested is not denominated in the Base Currency,
          that amount converted into the Base Currency at the Facility Agent's
          Spot Rate of Exchange on the date which is, subject as otherwise provided,
          three Business Days before the Utilisation Date or, if later, on the
          date the Facility Agent receives the Utilisation Request) adjusted
          to reflect any repayment, prepayment, consolidation or division of
          the Loan.

     "Basel
          II Implementation Date" means
          the date on which Basel II (as defined in sub-clause 20.3.1(f) of Clause
          20.3 (Exceptions) is deemed to apply
          to the Finance Parties being 1 January 2007.

     "Borrower" means
        an Original Borrower or an Additional Borrower unless it has ceased to
    be a Borrower in accordance with Clause 31 (Changes to the Obligors).

- 3 -

	 	"Break
        Costs" means the amount (if any)
    by which:  
	 	 	 
	 	
(a)  	
the interest excluding the Margin which a Lender should have received for the period from the date of receipt of all or any part of its participation in a Loan or Unpaid Sum to the last day of the current Interest Period in
respect of that Loan or Unpaid Sum, had the principal amount or Unpaid Sum received been paid on the last day of that Interest Period;  

	 	exceeds:  
	 	 	 
	 	
(b)  	
the amount which that Lender would be able to obtain by placing an amount equal to the principal amount or Unpaid Sum received by it on deposit with a leading bank in the Relevant Interbank Market for a period starting on
the Business Day following receipt or recovery and ending on the last day of the current Interest Period.  
	 	 	 
	 	"Business
        Day" means a day (other than a Saturday
    or Sunday) on which banks are open for general business in London and:  
	 	 	 
	 	(a)  	(in relation to any date for payment or purchase
      of a currency other than euro) the principal financial centre of the country
      of that currency; or  
	 	 	 
	 	(b)  	(in relation to any date for payment or purchase
      of euro) any TARGET Day.  
	 	 	 
	 	"Certain
          Funds Period" means the period
          commencing on the date of this Agreement and ending on the date which
          is the earlier of (i) five Business Days after the Acceptance Date
          and (ii) the Walk-Away Date.

     "Certain
          Funds Utilisation" means a Term
          Loan or Revolving Loan made or to be made under a Facility during the
          Certain Funds Period where such Loan is to be made solely for an Acquisition
          Purpose.

     "Code" means,
        at any date, the U.S. Internal Revenue Code of 1986 and the regulations
        promulgated thereunder as in effect at such date. 

     "Commitment" means
        a Facility A Commitment, a Facility B Commitment, a Revolving Facility
        Commitment or a Swingline Commitment.

     "Compliance
          Certificate" means a certificate
          substantially in the form set out in Schedule 8 (Form
          of Compliance Certificate).

     "Confidentiality
          Undertaking" means a confidentiality
          undertaking substantially in the form as set out in Schedule 12 (Form of Confidentiality Undertaking)
          or in any other form agreed between the Company and the Facility Agent.

     "Debt
          Proceeds" means the cash proceeds
          receivable by any member of the Group upon the incurrence by any member
          of the Group of any Financial Indebtedness falling within the terms
          of paragraphs (e) and (i) of sub-clause 28.8.2, after, in each case,
          deducting expenses incurred by any member of the Group with respect
    to that incurrence.

- 4 -

	 	"Default" means
        an Event of Default or any event or circumstance specified in Clause
        29 (Events of Default)
        which would (with the expiry of a grace period, the giving of notice,
        the making of any determination under the Finance Documents or any combination
        of any of the foregoing with an event or circumstance specified in Clause
        29 (Events of Default))
        be an Event of Default.

     "Disposal" means
        a sale, lease, licence, transfer, loan or other disposal by a person
        of any asset, undertaking or business (whether by a voluntary or involuntary
        single transaction or series of transactions).

     "Disposal
          Proceeds" means the cash consideration
          receivable by any member of the Group (including any amount receivable
          in repayment of intercompany debt) for any disposal under sub-clause
          28.4.2(k) of Clause 28.4 (Disposals)
          made by any member of the Group except for Excluded Disposal Proceeds
    and after deducting

	 	 	 
	 	
(a)  	
expenses and provisions for liability incurred by any member of the Group with respect to that disposal; and  
	 
	 	
(b)  	
any Tax incurred and required to be paid by any member of the Group in connection with that disposal (as reasonably determined by that member of the Group, on the basis of existing rates and taking account of any available
credit, deduction or allowance).  

	 	 
	 	"Dollar
            Swingline Facility" means the
            dollar swingline facility as described in sub-clause 7.1.1 of Clause
            7.1 (Swingline).

       "Dollar
    Swingline Lender" means:

	 	 

	 	
(a)  	
an Original Dollar Swingline Lender listed in Part IV of Schedule 1 (The Original Parties) as a dollar swingline lender; or  
	 
	 	
(b)  	
any other person that becomes a Dollar Swingline Lender after the date of this Agreement in accordance with Clause 30 (Changes to the Lenders),  
	 	 	 
	 	which
        in each case has not ceased to be a Party in accordance with the terms
        of this Agreement.

     "Dollar
          Swingline Loan" means a loan to
          be made under the Dollar Swingline Facility or the principal amount
          outstanding for the time being of that loan.

     "Employee
          Plan" means an employee pension
          benefit plan (other than a Multiemployer Plan) subject to the provisions
          of Title IV of ERISA or Section 412 of the Code or Section 302 of ERISA,
          and in respect of which a U.S. Obligor or any ERISA Affiliate is (or,
          if such plan were terminated, would under Section 4069 of ERISA be
          deemed to be) an "employer" as defined in Section 3(5) of ERISA.

     "ERISA" means,
        at any date, the United States Employee Retirement Income Security Act
        of 1974 and the regulations promulgated and rulings issued under it,
    all as the same may be in effect at such date.

- 5 -

	 	"ERISA
          Affiliate" means any person that
          for purposes of Title I and Title IV of ERISA and Section 412 of the
          Code would be deemed at any relevant time to be a single employer with
          a Obligor, pursuant to Section 414(b), (c), (m) or (o) of the Code
          or Section 4001 of ERISA.

     "ERISA
    Event" means:

	 	 	 
	 	
(a)  	
any reportable event, as defined in Section 4043 of ERISA, with respect to an Employee Plan, as to which PBGC has not by regulation waived the requirement of Section 4043(a) of ERISA that it be notified of such
event;  
	 
	 	
(b)  	
the filing of a notice of intent to terminate any Employee Plan, if such termination would require material additional contributions in order to be considered a standard termination within the meaning of Section 4041(b) of
ERISA, the filing under Section 4041(c) of ERISA of a notice of intent to terminate any Employee Plan or the termination of any Employee Plan under Section 4041(c) of ERISA;  
	 
	 	
(c)  	
the institution of proceedings under Section 4042 of ERISA by the PBGC for the termination of, or the appointment of a trustee to administer, any Employee Plan;  
	 
	 	
(d)  	
the failure to make a required contribution to any Employee Plan that would result in the imposition of an encumbrance under Section 412 of the Code or Section 302 of ERISA securing an amount in excess of US$50,000,000
or the filing of any request for a minimum funding waiver under Section 412 of the Code with respect to any Employee Plan or Multiemployer Plan;  
	 
	 	
(e)  	
an engagement in a non-exempt prohibited transaction within the meaning of Section 4975 of the Code or Section 406 of ERISA;  
	 
	 	
(f)  	
the complete or partial withdrawal of any U.S. Obligor or any ERISA Affiliate from a Multiemployer Plan; and  
	 
	 	
(g)  	
an Obligor or an ERISA Affiliate incurring any liability under Title IV of ERISA with respect to any Employee Plan (other than premiums due and not delinquent under Section 4007 of ERISA).  
	 	 	 
	 	"Euro
          Swingline Facility" means the
          euro swingline facility as described in sub-clause 7.1.2 of Clause
          7.1 (Swingline).

     "Euro
    Swingline Lender" means:

	 	
(a)  	
an Original Euro Swingline Lender listed in Part V of Schedule 1 (The Original Parties) as a euro swingline lender; or  
	 
	 	
(b)  	
any other person that becomes a Euro Swingline Lender after the date of this Agreement in accordance with Clause 30 (Changes to the Lenders),  
	 	 	 
	 	which in each case has
    not ceased to be a Party in accordance with the terms of this Agreement.  

- 6 -

	 	"Euro
          Swingline Loan" means a loan to
          be made under the Euro Swingline Facility or the principal amount outstanding
          for the time being of that loan.

     "Event
          of Default" means any event or
          circumstance specified as such in Clause 29 (Events
          of Default).

     "Excluded
          Acquisition Proceeds" means any
          proceeds of a Recovery Claim which the Company notifies the Facility
    Agent are, or are to be, applied:

	 	 	 
	 	
(a)  	
in payment of amounts payable pursuant to the Acquisition Agreement by way of adjustment to the purchase price in respect of the Acquisition (except to the extent relating to a working capital adjustment);  
	 
	 	
(b)  	
to satisfy (or reimburse a member of the Group which has discharged) any liability, charge or claim upon a member of the Group by a person which is not a member of the Group; or  
	 
	 	
(c)  	
in the replacement, reinstatement and/or repair of assets of members of the Group which have been lost, destroyed or damaged,  
	 	 	 
	 	 in
        each case as a result of the events or circumstances giving rise to that
        Recovery Claim, if those proceeds are so applied as soon as possible
        (but in any event within 365 days, or such longer period as the Majority
        Lenders may agree) after receipt.

     "Excluded
    Disposal Proceeds" means:

	 	 	 
	 	
(a)  	
any Disposal Proceeds which are within 365 days of the date of the relevant Disposal applied in or towards the purchase of assets used in the business of the Group (including, without limitation, all milestone payments and
similar payments under any new or existing agreement relating to the in-licensing co-development or other acquisition of intellectual property or other assets or products); and  
	 
	 	
(b)  	
any other Disposal Proceeds to the extent that, when aggregated with all other Disposal Proceeds receivable by the Group in the same financial year, they do not exceed US$100,000,000.  
	 	 	 
	 	"Existing
          Financial Indebtedness" means
          the existing Financial Indebtedness listed in Schedule 11 (Existing
          Financial Indebtedness).

     "Existing
          Loans" means the existing loans
          listed in Schedule 10 (Existing
          Loans).

     "Existing
          Security" means the existing Security
          listed in Schedule 9 (Existing
          Security).

     "Facility" means
        a Term Facility, the Revolving Facility or the Swingline Facility.

     "Facility
          A" means the term loan facility
          made available under this Agreement as described in Clause 2.1 (Grant
    of Facility A).

- 7 -

	 	"Facility
    A Commitment" means:  
	 	 	 
	 	
(c)  	
in relation to an Original Term Lender, the amount in the Base Currency set opposite its name under the heading "Facility A Commitment" in Part II of Schedule 1 (The Original
Parties) and the amount of any other Facility A Commitment transferred to it under this Agreement; and  
	 
	 	
(d)  	
in relation to any other Term Lender, the amount in the Base Currency of any Facility A Commitment transferred to it under this Agreement,  
	 	 	 
	 	to the
        extent not cancelled, reduced or transferred by it under this Agreement.

     "Facility
          A Lender" means a Term Lender
          under Facility A. 

     "Facility
          A Loan" means a loan made or to
          be made under Facility A or the principal amount outstanding for the
          time being of that loan.

     "Facility
          A Maturity Date" means the date
          which is the fifth anniversary of the date of this Agreement.

     "Facility
          A Repayment Date" means each of
          the dates specified in sub-clause 10.1.1 of Clause 10.1 (Repayment
          of Term Loans).

     "Facility
          Agent's Spot Rate of Exchange" means
          the Facility Agent's spot rate of exchange for the purchase of the
          relevant currency with the Base Currency in the London foreign exchange
          market at or about 11:00 a.m. on a particular day.

     "Facility
          B" means the term loan facility
          made available under this Agreement as described in Clause 2.2 (Grant
          of Facility B).

     "Facility
    B Commitment" means:

	 	
(a)  	
in relation to an Original Term Lender, the amount in the Base Currency set opposite its name under the heading "Facility B Commitment" in Part II of Schedule 1 (The Original
Parties) and the amount of any other Facility B Commitment transferred to it under this Agreement; and  
	 
	 	
(b)  	
in relation to any other Term Lender, the amount in the Base Currency of any Facility B Commitment transferred to it under this Agreement,  
	 	 	 
	 	to the
        extent not cancelled, reduced or transferred by it under this Agreement.

     "Facility
          B Loan" means a loan made or to
          be made under Facility B or the principal amount outstanding for the
          time being of that loan.

     "Facility
          B Maturity Date" means the date
          which is 364 days after the date of this Agreement subject to an extension
          pursuant to Clause 14 (Extension
    of Facility B).

- 8 -

	 	"Facility
    Office" means:  
	 	 	 
	 	
(a)  	
in relation to a Revolving Lender, the office identified as such opposite such Lender's name in Part III of Schedule 1 (The Original Parties) (or in
the case of a transferee, at the end of the Transfer Certificate to which it is a party as transferee) or such other office as it may from time to time select;  
	 
	 	
(b)  	
in relation to a Dollar Swingline Lender, the office identified as such opposite such Swingline Lender's name in Part IV of Schedule 1 (The Original Parties) (or in the case of a transferee, at the end of the Transfer Certificate to which it is a party as transferee) or such other office in the United States of America (in the same time zone as New York City) as it may from time to time
select; and  
	 
	 	
(c)  	
in relation to a Euro Swingline Lender, the office identified as such opposite such Swingline Lender's name in Part V of Schedule 1 (The Original Parties) (or in the case of a transferee, at the end of the Transfer Certificate to which it is a party as transferee) or such other office as it may from time to time select.  
	 	 	 
	 	"Fee
          Letter" means any letter or letters
          dated on or about the date of this Agreement between the Arranger and
          the Company (or an Agent and the Company) setting out any of the fees
          referred to in Clause 18 (Fees).

     "Finance
          Document" means this Agreement,
          the Mandate Letter, any Fee Letter, any Accession Letter, any Resignation
          Letter, any Utilisation Request and any other document designated as
          such by the Facility Agent and the Company.

     "Finance
          Party" means any Agent, the Arranger
          or a Lender.

     "Financial
          Indebtedness" means any indebtedness
    for or in respect of:

	 	
(a)  	
moneys borrowed;  
	 
	 	
(b)  	
any amount raised by acceptance under any acceptance credit facility or dematerialised equivalent;  
	 
	 	
(c)  	
any amount raised pursuant to any note purchase facility or the issue of bonds, notes, debentures, loan stock or any similar instrument;  
	 
	 	
(d)  	
the amount of any liability in respect of any lease or hire purchase contract which would, in accordance with U.S. GAAP, be treated as a finance or capital lease;  
	 
	 	
(e)  	
receivables sold or discounted (other than any receivables to the extent they are sold on a non-recourse basis);  
	 
	 	
(f)  	
any amount raised under any other transaction (including any forward sale or purchase agreement) having the commercial effect of a borrowing;  
	 
	 	
(g)  	
any derivative transaction entered into in connection with protection against or benefit from fluctuation in any rate or price (and, when calculating the value of any derivative transaction, only the marked to market value
shall be taken into account);  

- 9 -

	 	
(h)  	
any counter-indemnity obligation in respect of a guarantee, indemnity, bond, standby or documentary letter of credit or any other instrument issued by a bank or financial institution;  
	 
	 	
(i)  	
any amount raised by the issue of redeemable shares which are redeemable prior to the fifth anniversary of the date of the Agreement other than redeemable shares issued by a Subsidiary of the Company where such redeemable
shares are acquired by another member of the Group as consideration for, or in connection with, an issue by a member of the Group of equity securities or, to the extent not so acquired, are redeemed within 30 days after the date of their
issue;  
	 
	 	
(j)  	
any amount of any liability under an advance or deferred purchase agreement if one of the primary reasons behind the entry into this agreement is to raise finance; and  
	 
	 	
(k)  	
(without double counting) the amount of any liability in respect of any guarantee or indemnity for any of the items referred to in paragraphs (a) to (j) above.  
	 	 	 
	 	"Group" means
        the Company and its Subsidiaries for the time being, including after
        closing of the Acquisition, New River and its Subsidiaries.

     "Guarantor" means
        an Original Guarantor or an Additional Guarantor, unless it has ceased
        to be a Guarantor in accordance with Clause 31 (Changes
        to the Obligors).

     "Holding
          Company" means, in relation to
          a company or corporation, any other company or corporation in respect
          of which it is a Subsidiary.

     "Information
          Memorandum" means the document
          that is to be prepared in relation to this transaction, approved by
          the Company and distributed by the Arrangers in connection with the
          syndication of the Facilities.

     "Information
          Memorandum Date" means the date
          on which the Information Memorandum is approved by the Company for
          distribution.

     "Interest
          Period" means, in relation to
          a Loan (not being a Swingline Loan), each period determined in accordance
          with Clause 16 (Interest Periods), in
          relation to an Unpaid Sum, each period determined in accordance with
          Clause 15.3 (Default interest), and in relation to a Swingline Loan, the period determined in
          accordance with sub-clause 6.3.1 of Clause 6.3 (Completion
          of a Utilisation Request for Swingline Loans).

     "IRS" means
        the United States Internal Revenue Service or any successor.

     "Lender" means
        a Swingline Lender and/or a Revolving Lender and/or a Term Lender, as
        the context requires.

     "LIBOR" means,
    in relation to any Loan:

	 	 	 
	 	(a)  	the applicable Screen Rate; or  
	 	 	 
	 	(b)  	(if no Screen Rate is available for the currency
      or Interest Period of that Loan) the arithmetic mean of the rates (rounded
      upwards to four decimal places) as supplied to  

- 10 -

	 	the Facility Agent at its request
        quoted by three Reference Banks to leading banks in the London interbank
    market,  

	 	as of the Specified
        Time on the Quotation Day for the offering of deposits in the currency
        of that Loan and for a period comparable to the Interest Period for that
    Loan.  
	 	 
	 	"Loan" means
          a Revolving Loan, a Swingline Loan or a Term Loan.

       "Major
    Event of Default" means:

	 	
(a)  	
with respect to any Obligor, any circumstances constituting
an Event of Default under Clause 29.1 (Non-payment),
Clause 29.3 (Other Obligations) (but only
with respect to failure to comply with Clauses 28.3 (Negative
Pledge), 28.4 (Disposals),     28.5
(Change of Business),
28.7 (Loans and Guarantees),
28.8 (Financial
Indebtedness)
and, for the purpose of this definition only, any reference in each such clause
to the Group or a member of the Group shall be deemed not to include New River
and its subsidiaries), Clause 29.4 (Misrepresentation)
(but only insofar as it relates to a Major Representation), Clause 29.10 (Unlawfulness) or Clause 29.11
(Repudiation);
and 
	 
	 	
(b)  	
any circumstances constituting a Default under Clause
29.6 (Insolvency)
or Clause        29.7
(Insolvency Proceedings).   
	 	 	 
	 	"Major
          Representation" means a representation
          or warranty with respect to any Obligor other than New River under
          Clauses 25.2 (Status) to 25.6 (Validity
          and admissibility in evidence)
          inclusive except that, for the purpose of this definition, all references
          in such Clauses to a "Subsidiary" or the "Subsidiaries" of any Obligors
          in sub-clauses 25.2.2 of Clause 25.2 (Status)
          and 25.4.2 of Clause 25.4 (Non-conflict with other obligations)
          shall be deemed to refer only to Material Companies.

     "Majority
    Lenders" means:

	 	 	 
	 	(a)  	if there are no Loans then outstanding,
      a Lender or Lenders whose Commitments aggregate not less than 662/3 per
      cent. of the Total Commitments (or, if the Total Commitments have been
      reduced to zero, aggregated not less than 662/3 per
    cent. of the Total Commitments immediately prior to the reduction); or  
	 	 	 
	 	(b)  	at any other time, a Lender or Lenders
      whose participations in the Loans then outstanding aggregate not less than
      662/3 per
    cent. of all the Loans then outstanding.  
	 	 	 
	 	"Mandate
          Letter" means the letter dated
          on or about the date hereof between the Company and the Arrangers.

     "Mandatory
          Cost" means the percentage rate
          per annum calculated by the Facility Agent in accordance with Schedule
          4 (Mandatory Cost formulae).

     "Margin" means:

    
	 	 	 
	 	(a)  	  in
    the case of the Revolving Facility and Facility A:  

- 11 -

	 	 	
(i)  	
0.80 per cent. per annum prior to receipt by the Facility Agent of the Compliance Certificate delivered in respect of the year ending 31 December 2007, pursuant to Clause 26 (Information
Undertakings); and  
	 
	 	 	
(ii)  	
at all other times if the ratio of Net Debt to EBITDA in respect of the most recently completed financial year or financial half year is within the range set out below, then the Margin will be the rate set out opposite such
range in the table below:  

	 	 	 	 
	 	Ratio of Net Debt to EBITDA  	     	
Margin (per cent. per annum)    
	     
	 	
Greater than 3.0:1  	        	
0.80  
	 	
Greater than
2.5:1
but less than or equal to 3.0:1  	        	
0.65  
	 	
Greater than
2.0:1
but less than or equal to 2.5:1  	        	
0.55  
	 	
Greater than
1.5:1
but less than or equal to 2.0:1  	        	
0.45  
	 	
Less than or equal to 1.5:1  	        	
0.40  

	 	and any
        reduction or increase in the Margin in the table above shall take effect
        five Business Days after receipt by the Facility Agent of the Compliance
        Certificate pursuant to Clause 26 (Information Undertakings).
        For the purpose of determining the Margin, "Net Debt" and "EBITDA" shall
        be determined in accordance with Clause 27.1 (Financial
        definitions). 

     If the Company is in default of
        its obligations under Clause 26 (Information
        Undertakings) to provide a Compliance
        Certificate or relevant financial statements and the Company has failed
        to remedy the default within 5 Business Days following notification by
        the Facility Agent, the Margin will be 0.80 per cent. per annum for so
    long as such default continues. 

	 	 	 
	 	
(b)  	
in the case of Facility B the Margin will be the rate set out opposite the time period in the table below:  

	 	
Months from the date of this Agreement  	   	
Margin (per cent. per annum)    
	 	 	 	 
	 	
0-6 months  	     	
0.50  
	 	 	 	 
	 	
7-12 months  	     	
0.75  
	 	 	 	 
	 	
after 12 months and thereafter  	     	
1.00  

	 	Any
          increase in the Margin under the terms of paragraph (b) shall take
          effect from the last day of the last month in each period specified
          above.

         "Margin
              Stock" means margin stock
              or "margin security" within the meaning of Regulations U and X.

- 12 -

	 	"Material
    Adverse Effect" means a:
	 	 	 
	 	
(a)  	
material adverse change in the business, operations, assets or financial condition of the Group taken as a whole which is likely to have a material adverse effect on the ability of the Obligors taken as a whole or the
Company to perform their respective payment obligations under the Finance Documents; or  
	 
	 	
(b)  	
material adverse effect on the validity or enforceability of the Finance Documents or the rights or remedies of any Finance Party under the Finance Documents.  

	 	"Material
    Company" means, at any time:  
	 	 	 
	 	
(a)  	
an Obligor; or  
	 
	 	
(b)  	
a Subsidiary of the Company which has EBITDA (as defined in Clause 27.1 (Financial definitions) but calculated as though it applied to it)
representing 10 per cent. or more of the EBITDA of the Group.  
	 	 	 
	 	Compliance
        with such conditions shall be determined by reference to the most recent
        Compliance Certificate supplied by the Company and/or the latest audited
        financial statements of that Subsidiary (consolidated in the case of
        a Subsidiary which itself has Subsidiaries) and the latest audited consolidated
        financial statements of the Group.

     A report by the auditors of the
        Company that a Subsidiary is or is not a Material Company (determined
        in accordance with the preceding paragraph) shall, in the absence of
        manifest error, be conclusive and binding on all Parties.

     "Maturity
          Date" means, as applicable, the
          Facility A Maturity Date, the Facility B Maturity Date, or the Revolving
          Facility Maturity Date.

     "Month" means
        a period starting on one day in a calendar month and ending on the numerically
    corresponding day in the next calendar month, except that:

	 	
(a)  	
(subject to paragraph (c) below) if the numerically corresponding day is not a Business Day, that period shall end on the next Business Day in that calendar month in which that period is to end if there is one, or if there
is not, on the immediately preceding Business Day;  
	 
	 	
(b)  	
if there is no numerically corresponding day in the calendar month in which that period is to end, that period shall end on the last Business Day in that calendar month; and  
	 
	 	
(c)  	
if an Interest Period begins on the last Business Day of a calendar month, that Interest Period shall end on the last Business Day in the calendar month in which that Interest Period is to end.  
	 	 	 
	 	The
        above rules will only apply to the last Month of any period.

     "Multiemployer
          Plan" means a "multiemployer plan" (as
          defined in Section (3)(37) of ERISA) contributed to for any employees
    of a U.S. Obligor or any ERISA Affiliate.

- 13 -

	 	"New
            River" means New River Pharmaceuticals,
            Inc

       "NRP
            104 Milestone Payment" means
            the milestone payment payable under the agreement between the Company, inter
            alia, and New River Pharmaceuticals
            Inc. dated 31 January 2005 triggered by various events, such as filing,
            receiving U.S. marketing approval with certain characteristics, and
            achieving certain sales targets.

       "Obligor" means
          a Borrower or a Guarantor.

       "Optional
            Currency" means a currency (other
            than the Base Currency) which complies with the conditions set out
            in Clause 4.4 (Conditions relating to Optional Currencies).

       "Original
            Financial Statements" means
            in relation to the Company, the audited consolidated financial statements
            of the Group for the financial year ended 31 December 2005.

       "Original
            Obligor" means an Original Borrower
            or an Original Guarantor.

       "Participating
            Member State" means any member
            state of the European Communities that adopts or has adopted the
            euro as its lawful currency in accordance with legislation of the
            European Community relating to Economic and Monetary Union.

       "Party" means
          a party to this Agreement.

       "PBGC" means
          the U.S. Pension Benefit Guaranty Corporation, or any entity succeeding
          to all or any of its functions under ERISA. 

       "Permitted
            Securitisation" means any arrangements
            forming part of a transaction involving the securitisation or other
            financing of assets or cash flows (or both) relating to royalty income
            provided that, while the aggregate amount of the Total Revolving
            Facility Commitments of all the Revolving Lenders in respect of the
            Revolving Facility is greater than US$500,000,000 or there is
            any amount outstanding under or in respect of Facility A or Facility
            B, the Company provides a certificate to the Facility Agent signed
            by two directors (one of which is the finance director of the Company)
            confirming that the proceeds of that securitisation or other financing
            are to be applied such that there will be a permanent reduction of
            the Facilities of an amount equivalent to the net amount anticipated
            to be received by the Group from such securitisation or other financings.

       "Qualifying
            Lender" has the meaning given
            to it in Clause 19 (Tax gross-up
            and indemnities).

       "Quotation
            Day" means, in relation to any
    period for which an interest rate is to be determined:

	 	
(a)  	
(if the currency is sterling) the first day of that period;  
	 
	 	
(b)  	
(if the currency is euro) two TARGET Days before the first day of that period; or  
	 
	 	
(c)  	
(for any other currency) two Business Days before the first day of that period,  

- 14 -

	 	unless
        market practice differs in the Relevant Interbank Market for a currency,
        in which case the Quotation Day for that currency will be determined
        by the Facility Agent in accordance with market practice in the Relevant
        Interbank Market (and if quotations would normally be given by leading
        banks in the Relevant Interbank Market on more than one day, the Quotation
        Day will be the last of those days).

     "Reference
          Banks" means, in relation to LIBOR
          the principal London offices of Citibank International plc, Barclays
          Bank PLC and The Royal Bank of Scotland plc or such other banks as
          may be appointed by the Facility Agent in consultation with the Company.

     "Regulations
          U and X" means, respectively,
          Regulations U and X of the Board of Governors of the Federal Reserve
          System of the United States (or any successor) as now and from time
          to time in effect from the date of this Agreement.

     "Relevant
          Interbank Market" means in relation
          to euros, the European Interbank Market and, in relation to any other
          currency, the London interbank market.

     "Repayment
          Instalment" means the amount to
          be repaid on each Facility A Repayment Date.

     "Repeating
          Representations" means each of
          the representations set out in Clauses 25.2 (Status) to 25.7 (Governing
          law and enforcement), Clause 25.10
          (No default),
          Clause 25.13 (Pari passu ranking),
          and Clause 25.14 (ERISA and Multiemployer
          Plans) to Clause 25.16 (Investment Companies).

     "Resignation
          Letter" means a letter substantially
          in the form set out in Schedule 7 (Form
          of Resignation Letter).

     "Revolving
          Facility" means the revolving
          facility made available under this Agreement as described in Clause
          2.3 (Grant of Revolving Facility).

     "Revolving
    Facility Commitment" means:

	 	 	 
	 	
(a)  	
in relation to an Original Revolving Lender, the amount in the Base Currency set opposite its name under the heading "Revolving Commitment" in Part III of Schedule 1 (The Original
Parties) and the amount of any other Revolving Facility Commitment transferred to it under this Agreement; and  
	 
	 	
(b)  	
in relation to any other Revolving Lender, the amount in the Base Currency of any Revolving Facility Commitment transferred to it under this Agreement,  
	 	 	 
	 	to
        the extent not cancelled, reduced or transferred by it under this Agreement.

     "Revolving
          Facility Maturity Date" means
          the date which is the fifth anniversary of the date of this Agreement.

     "Revolving
    Lender" means:

	 	 	 
	 	(a)  	any Original Revolving Lender; and  

- 15 -

	 	
(b)  	
any bank or financial institution which has become a Revolving Lender in accordance with Clause 30 (Changes to the Lenders), which in each case has
not ceased to be a Party in accordance with the terms of this Agreement.  
	 	 	 
	 	"Revolving
          Loan" means a loan to be made
          under the Revolving Facility or the principal amount outstanding for
          the time being under that loan.

     "Rollover
          Loan" means one or more Revolving
    Loans (other than Swingline Loans):

	 	
(a)  	
made or to be made on the same day that a maturing Revolving Loan is due to be repaid;  
	 
	 	
(b)  	
the aggregate amount of which is equal to or less than the maturing Revolving Loan;  
	 
	 	
(c)  	
in the same currency as the maturing Revolving Loan (unless it arose as a result of the operation of Clause 8.3 (Revocation of currency));
and  
	 
	 	
(d)  	
made or to be made to the same Borrower for the purpose of refinancing a maturing Revolving Loan.  
	 	 	 
	 	 "Screen
          Rate" means in relation to LIBOR,
          the British Bankers' Association Interest Settlement Rate for the relevant
          currency and period displayed on the appropriate page of the Telerate
          screen. If the agreed page is replaced or service ceases to be available,
          the Facility Agent may specify a reasonable alternative page or service
          displaying the appropriate rate after consultation with the Company
          and the Lenders.

     "SEC" means
        the United States Securities and Exchange Commission or any successor
        thereto.

     "Security" means
        a mortgage, charge, pledge, lien or other security interest securing
        any obligation of any person or any other agreement or arrangement having
        a similar effect.

     "Specified
          Time" means a time determined
          in accordance with Schedule 13 (Timetables).

     "Subsidiary" means
        a subsidiary within the meaning of section 736 of the Companies Act 1985.

     "Swingline
          Agent" means the Dollar Swingline
          Agent or the Euro Swingline Agent. 

     "Swingline
    Commitment" means:

	 	 	 
	 	(a)  	in relation to a Swingline Lender on the date
      of this Agreement, the amount in the Base Currency set opposite its name
      under the heading "Swingline Commitment" in Part III and/or Part IV of
      Schedule 1 (The Original Parties)
      and the amount of any other Swingline Commitment transferred to it under
      this Agreement; or  
	 	 	 
	 	(b)  	in relation to any other Swingline Lender, the
      amount in the Base Currency of any Swingline Commitment transferred to
      it under this Agreement,  
	 	 	 
	 	to the extent not
    cancelled, reduced or transferred by it under this Agreement.  

- 16 -

 

	 	"Swingline
          Facility" means the swingline
          facility made available under this Agreement comprising the Dollar
          Swingline Facility, and the Euro Swingline Facility.

     "Swingline
          Lender" means a Dollar Swingline
          Lender or a Euro Swingline Lender.

     "Swingline
          Loan" means a Dollar Swingline
          Loan or a Euro Swingline Loan.

     "Syndication
          Date" means the date on which
          the Arrangers confirm that primary syndication has been completed.

     "TARGET" means
        Trans-European Automated Real-time Gross Settlement Express Transfer
        payment system.

     "TARGET
          Day" means any day on which TARGET
          is open for the settlement of payments in euro.

     "Tax" means
        any tax, levy, impost, duty or other charge or withholding of a similar
        nature (including any penalty or interest payable in connection with
        any failure to pay or any delay in paying any of the same).

     "Taxes
          Act" means the Income and Corporation
          Taxes Act 1988.

     "Tender
          and Support Agreement" means the
          tender and support agreement dated on or around the date of this Agreement
          between the Shareholders of New River referred to therein and the Company.

     "Term
          Facility" means Facility A or
          Facility B.

     "Term
    Lender" means:

	 	 	 
	 	
(a)  	
any Original Term Lender; and  
	 
	 	
(b)  	
any bank or financial institution which has become a Term Lender in accordance with Clause 30 (Changes to the Lenders) which, in each case, has not
ceased to be a Party in accordance with the terms of this Agreement.  
	 	 	 
	 	"Term
          Loan" means a Facility A Loan
          or a Facility B Loan.

     "Total
          Commitments" means the aggregate
          of the Total Facility A Commitments, the Total Facility B Commitments
          and the Total Revolving Facility Commitments, being US$2,300,000,000
          at the date of this Agreement.

     "Total
          Facility A Commitments" means
          the aggregate of the Facility A Commitments, being US$1,000,000,000
          at the date of this Agreement.

     "Total
          Facility B Commitments" means
          the aggregate of the Facility B Commitments, being US$300,000,000
          at the date of this Agreement.

     "Total
          Revolving Facility Commitments" means
          the aggregate of the Revolving Facility Commitments, being US$1,000,000,000
    at the date of this Agreement.

- 17 -

	 	 	 	 	 
	 	
"Transfer Certificate" means a certificate substantially in the form set out in Schedule 5 (Form of Transfer
Certificate) or any other form agreed between the Facility Agent and the Company.  
	 
	 	
"Transfer Date" means, in relation to a transfer, the later of:  
	 
	 	(a)  	
 the proposed Transfer Date specified in the Transfer
Certificate; and  
	 
	 	(b)  	
 the date on which the Facility Agent executes the
Transfer Certificate.  
	 
	 	
"Unfunded Pension
Liability" means the excess of an Employee
Plan's benefit liabilities under Section 4001(a)(16) of ERISA, over the current
value of  that plan's assets, determined in accordance with the assumptions used
for funding the Employee Plan pursuant to Section        412
of the Code for the applicable plan year.   
	 
	 	
"U.S." and "United States" means the United States of America, its
territories, possessions and other areas subject to the jurisdiction of the United States of America.  
	 
	 	
"U.S. Borrower" means a Borrower whose jurisdiction of organisation is a state of the United States of America or the District of
Columbia.  
	 
	 	
"U.S. GAAP" means generally accepted accounting principles in the United States of America.  
	 
	 	
"U.S. Guarantor" means a Guarantor whose jurisdiction of organisation is a state of the United States of America or the District of
Columbia.  
	 
	 	
"U.S. Obligor" means a U.S. Borrower or a U.S. Guarantor.  
	 
	 	
"Unpaid Sum" means any sum due and payable but unpaid by an Obligor under the Finance Documents.  
	 
	 	
"Utilisation" means a utilisation of a Facility.  
	 
	 	
"Utilisation Date" means the date of a Utilisation, being the date on which the relevant Loan is to be made.  
	 
	 	
"Utilisation Request" means a notice substantially in the form set out in Part I (Utilisation Request - Term Loans
and Revolving Loan) or Part II (Utilisation Request - Swingline Loan) of Schedule 3 (Requests).  
	 
	 	
"VAT" means value added tax as provided for in the Value Added Tax Act 1994 or any regulations promulgated thereunder and any other tax of a similar
nature.  
	 
	 	
"Walk-Away Date" has the meaning set out in the Acquisition Agreement.  
	 
	1.2  	
      Construction      
	 	 	
1.2.1   	
Unless a contrary indication appears any reference in this Agreement to:  
	 
	 	 	 	
(a)  	
the "Agent", the "Facility Agent", the "Euro Swingline Agent", the "Dollar Swingline Agent", the "Arrangers", any "Finance Party", any "Lender",  

- 18 -

	 	 	 	any "Obligor" or
      any "Party" shall
      be construed so as to include its successors in title, permitted assigns
    and permitted transferees;  
	 	 	 	 
	 	 	
(b)  	
"assets" includes present and future properties, revenues and rights of every description;  
	 
	 	 	
(c)  	
a "Finance Document" or any other agreement or instrument is a reference to that Finance Document or other agreement or instrument as amended or
novated;  
	 
	 	 	
(d)  	
"indebtedness" includes any obligation (whether incurred as principal or as surety) for the payment or repayment of money, whether present or future,
actual or contingent;  
	 
	 	 	
(e)  	
a "person" includes any person, firm, company, corporation, government, state or agency of a state or any association, trust or partnership (whether
or not having separate legal personality) of two or more of the foregoing;  
	 
	 	 	
(f)  	
a "regulation" includes any regulation, rule, official directive or guideline (whether or not having the force of law but if not having the force of
law being of a type which any person to which it applies is accustomed to comply) of any governmental, intergovernmental or supranational body, agency, department or regulatory, self-regulatory or other similar authority or
organisation;  
	 
	 	 	
(g)  	
a provision of law is a reference to that provision as amended or re-enacted;  
	 
	 	 	
(h)  	
a time of day is a reference to London time; and  
	 
	 	 	
(i)  	
a reference to Barclays Capital means the investment banking division of Barclays Bank PLC.  
	 
	 	
1.2.2  	
Section, Clause and Schedule headings are for ease of reference only.  
	 
	 	
1.2.3  	
Unless a contrary indication appears, a term used in any other Finance Document or in any notice given under or in connection with any Finance Document has the same meaning in that Finance Document or notice as in this
Agreement.  
	 
	 	
1.2.4  	
A Default or an Event of Default is "continuing" if it has not been remedied or waived.  
	 	 	 
	1.3  	Currency Symbols and Definitions
	 	"$" and "dollars", "US
        Dollars" and "US$" denote
    lawful currency of the United States of America.  
	 	 	 
	 	"EUR" and "euro" means
    the single currency unit of the Participating Member States.  
	 	 	 
	 	"£" and "sterling" denote
    lawful currency of the United Kingdom.  

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1.4  	
Third party rights      
	 	
1.4.1  	
Unless expressly provided to the contrary in a Finance Document, a person who is not a Party has no right under the Contracts (Rights of Third Parties) Act 1999 (the "Third Parties
Act") to enforce or to enjoy the benefit of any term of this Agreement.  
	 
	 	
1.4.2  	
Notwithstanding any term of any Finance Document, the consent of any person who is not a Party is not required to rescind or vary this Agreement at any time.  

- 20 -

SECTION 2

THE FACILITIES

	 	 	 	 
	
2.  	
THE FACILITIES  
	 
	
2.1  	
Grant of Facility A     
	 	
Subject to the terms of this Agreement, the Facility A Lenders make available to the Borrowers a term loan facility in the Base Currency in an aggregate amount equal to the Total Facility A Commitments.  
	 
	
2.2  	
Grant of Facility B     
	 	
Subject to the terms of this Agreement, the Facility B Lenders make available to the Borrowers a term loan facility in the Base Currency in an aggregate amount equal to the Total Facility B Commitments.  
	 
	
2.3  	
Grant of Revolving Facility     
	 	
Subject to the terms of this Agreement, the Revolving Lenders make available to the Borrowers a multicurrency revolving loan facility in an aggregate amount equal to the Total Revolving Facility Commitments. The Revolving
Facility incorporates the Swingline Facility as set out in Clause 6 (Utilisation - Swingline Loans) and Clause 7 (Swingline
Loans).  
	 
	
2.4  	
Finance Parties' rights and obligations 
	 	
2.4.1  	
The obligations of each Finance Party under the Finance Documents are several. Failure by a Finance Party to perform its obligations under the Finance Documents does not affect the obligations of any other Party under the
Finance Documents. No Finance Party is responsible for the obligations of any other Finance Party under the Finance Documents.  
	 
	 	
2.4.2  	
The rights of each Finance Party under or in connection with the Finance Documents are separate and independent rights and any debt arising under the Finance Documents to a Finance Party from an Obligor shall be a separate
and independent debt.  
	 
	 	
2.4.3  	
A Finance Party may, except as otherwise stated in the Finance Documents, separately enforce its rights under the Finance Documents.  
	 
	
3.  	
PURPOSE 
	 
	
3.1  	
Purpose 
	 	
3.1.1  	
Each Borrower shall apply all amounts borrowed by it under a Term Facility towards:  
	 
	 	 	
(a)  	
financing the purchase price payable in respect of the Acquisition including related fees, and transaction costs; and  
	 
	 	 	
(b)  	
refinancing any existing indebtedness of New River and its Subsidiaries.  
	 
	 	
3.1.2  	
Each Borrower shall apply all amounts borrowed by it under the Revolving Facility towards:  

- 21 -

	 	 	(a)   	financing the balance of the consideration payable
      in respect of the Acquisition after the application of amounts drawn under
      the Term Loans, including related costs and expenses (including but not
      limited to legal costs and expenses (plus amounts in respect of any VAT
      thereon) incurred in relation to this Agreement and related documentation
      and any fees payable by the Borrower under this Agreement) and syndication
    costs;  
	 	 	 	 
	 	 	
(b)  	
the making of certain milestone payments;  
	 
	 	 	
(c)  	
refinancing indebtedness outstanding under the 2005 Agreement;  
	 
	 	 	
(d)  	
refinancing existing indebtedness of New River and its Subsidiaries;  
	 
	 	 	
(e)  	
financing the general corporate purposes of the Group.  
	 
	
3.2  	
Monitoring      
	 	
No Finance Party is bound to monitor or verify the application of any amount borrowed pursuant to this Agreement.  
	 
	
4.  	
CONDITIONS OF UTILISATION       
	 
	
4.1  	
Initial conditions precedent    
	 	
No Borrower (nor the Company) may deliver a Utilisation Request unless the Facility Agent has received all of the documents and other evidence listed in Part I of Schedule 2 (Conditions
precedent) in form and substance satisfactory to the Facility Agent acting reasonably. The Facility Agent shall notify the Company and the Lenders promptly upon being so satisfied.  
	 
	
4.2  	
Certain Funds Utilisation conditions precedent  
	 	
No Borrower (nor the Company) may deliver a Utilisation Request in respect of a Certain Funds Utilisation unless the Facility Agent has received all of the documents and other evidence listed in Part II of Schedule 2
(Conditions Precedent) in form and substance satisfactory to the Facility Agent acting reasonably. The Facility Agent shall notify the Company and the Lenders promptly upon
being so satisfied.  
	 
	
4.3  	
Further conditions precedent    
	 	
4.3.1  	
The Lenders will be obliged to comply with Clause 5.4 (Lenders' participation) in relation to a Loan (other than one to which Clause 4.7
(Loans during the Certain Funds Period) applies) only if on the date of the Utilisation Request and on the proposed Utilisation Date:  
	 
	 	 	
(a)  	
in the case of a Rollover Loan, no Event of Default has occurred and is continuing or would result from the proposed Loan and, in the case of any other Loan, no Default is
continuing or will result from the proposed Loan; and  
	 
	 	 	
(b)  	
the Repeating Representations to be made by each Obligor are true in all material respects.  

- 22 -

	 	 	 	 
	
4.4  	
Conditions relating to Optional Currencies      
	 	
4.4.1  	
A currency will constitute an Optional Currency in relation to a Revolving Loan if it is sterling or euro or it is:  
	 
	 	 	
(a)  	
readily available in the amount required and freely convertible into the Base Currency in the Relevant Interbank Market on the Quotation Day and the Utilisation Date for that Revolving Loan; and  
	 
	 	 	
(b)  	
a currency which has been approved by the Facility Agent (acting on the instructions of all the Revolving Lenders acting reasonably) on or prior to receipt by the Facility Agent of the relevant Utilisation Request for that
Revolving Loan.  
	 
	 	
4.4.2  	
If the Facility Agent has received a written request from the Company for a currency to be approved under sub-clause 4.3.1 above, the Facility Agent will confirm to the Company by the Specified Time:  
	 
	 	 	
(a)  	
whether or not the Revolving Lenders have granted their approval; and  
	 
	 	 	
(b)  	
if approval has been granted, the minimum amount for any subsequent Utilisation in that currency which will be an amount equivalent to US$10,000,000 (rounded to the nearest 1,000,000).  
	 
	
4.5  	
Maximum number of Loans 
	 	
4.5.1  	
A Borrower may not deliver a Utilisation Request if as a result of the proposed Utilisation 16 or more Loans would be outstanding unless otherwise agreed by the Company and the Facility Agent.  
	 
	 	
4.5.2  	
Any Loan made by a single Lender under Clause 8.3 (Revocation of Currency) shall not be taken into account in this Clause 4.5.  
	 
	
4.6  	
Maximum number of currencies    
	 	
A Borrower may not deliver a Utilisation Request if as a result of the proposed Utilisation Loans denominated in 7 or more currencies would be outstanding unless otherwise agreed by the Company and the Facility
Agent.  
	 
	
4.7  	
Utilisations during the Certain Funds Period    
	 	
4.7.1  	
Subject to Clause 4.1 (Initial conditions precedent) (other than in respect of 3 (g) of Part I of Schedule 2 (Conditions precedent)), during the Certain Funds Period, the Lenders shall be obliged to comply with Clause 5.4 (Lenders' participation) in relation to a Certain Funds Utilisation, unless on the date of the Utilisation Request and on the proposed Utilisation Date:  
	 
	 	 	
(a)  	
a Major Event of Default is continuing or would result from the proposed Utilisation;  
	 
	 	 	
(b)  	
a Major Representation is untrue or misleading; and  

- 23 -

	 	 	
(c)  	
a change of control (as described in Clause 12.1 (Mandatory Prepayment on Change of Control) has occurred.  
	 
	 	
4.7.2  	
During the Certain Funds Period (save in circumstances where, pursuant to sub- clause 4.7.1 above, a Lender is not obliged to comply with Clause 5.4 (Lenders'
participation) and subject as provided in Clause 11.1 (Illegality)), none of the Finance Parties shall be entitled to:  
	 
	 	 	
(a)  	
cancel any of its Commitments to the extent to do so would prevent or limit the making of a Certain Funds Utilisation;  
	 
	 	 	
(b)  	
rescind, terminate or cancel this Agreement or any of the Facilities or exercise any similar right or remedy or make or enforce any claim under the Finance Documents it may have to the extent to do so would prevent or limit
the making of a Certain Funds Utilisation;  
	 
	 	 	
(c)  	
refuse to participate in the making of a Certain Funds Utilisation;  
	 
	 	 	
(d)  	
exercise any right of set-off or counterclaim in respect of a Utilisation to the extent to do so would prevent or limit the making of a Certain Funds Utilisation; or  
	 
	 	 	
(e)  	
cancel, accelerate or cause repayment or prepayment of any amounts owing hereunder or under any other Finance Document to the extent to do so would prevent or limit the making of a Certain Funds Utilisation,  
	 
	 	 	
provided that, immediately upon the expiry of the Certain Funds Period, all such rights, remedies and entitlements shall be available to the Finance Parties notwithstanding that they
may not have been used or been available for use during the Certain Funds Period.  

- 24 -

SECTION 3

UTILISATION

	 	 	 
	
5.  	
UTILISATION - PROCEDURE 
	 
	
5.1  	
Delivery of a Utilisation Request       
	 	
A Borrower may
utilise a Facility (other than for the purpose of drawing Swingline Loans   which
may be drawn in accordance with Clause 6.2 (Delivery
of a Utilisation Request for Swingline Loans))
by delivery by it (or the Company on behalf of the Borrower) to the Facility
Agent of a duly completed Utilisation Request not later than the Specified Time.  
	 
	
5.2  	
Completion of a Utilisation Request     
	 	5.2.1  	Each Utilisation Request delivered to the Facility
    Agent pursuant to Clause 5.1  
	 	 	 
	 	 	
(Delivery of a Utilisation Request) is irrevocable and will not be regarded as having been duly completed unless:  
	 
	 	 	
(a) it identifies the Facility to be utilised;  
	 
	 	 	
(b) the proposed Utilisation Date is a Business Day within the Availability Period applicable to that Facility;  
	 
	 	 	
(c) the currency and amount of the Utilisation comply with Clause 5.3 (Currency and amount); and  
	 
	 	 	
(d) the proposed Interest Period complies with Clause 16 (Interest Periods).  
	 
	 	5.2.2  	Only one Loan may be requested in each Utilisation
    Request delivered to the Facility Agent pursuant to Clause 5.1 (Delivery
    of a Utilisation Request).    
	 
	
5.3  	
Currency and amount     
	 	5.3.1   	The currency specified in a Utilisation Request
    delivered to the Facility Agent  pursuant to Clause 5.1 (Delivery
    of a Utilisation Request) for the purpose
    of drawing Loans must be the Base Currency or, in the case of the Revolving
    Facility only, the Base Currency or an Optional Currency.  
	 	 	 
	 	5.3.2   	The
    amount of the proposed Loan must be:  
	 

	 	 	(a)  	 an amount equal to US$10,000,000 for
    Facility A or, if less, the Available Facility; or  
	 
	 	 	(b)  	an amount equal to US$10,000,000 for
    Facility B or, if less, the Available Facility; or  
	 
	 	 	(c)  	 for the Revolving Facility:  
	 
	 	 	 	(i)  	(i) if the
        currency selected is the Base Currency, a minimum of US$10,000,000
        or, if less, the Available Facility; or  
	 
	 	 	 	(ii)  	(ii) if the
        currency selected is euro, a minimum of the euro equivalent of US$10,000,000
        (rounded to the nearest 1,000,000), or if the currency  

- 25 -

	 	 	 	 	selected is sterling, a minimum of the sterling
        equivalent of US$10,000,000 (rounded to the nearest 1,000,000), or
        if the currency selected is another an Optional Currency other than euro
        or sterling, the minimum amount specified by the Agent pursuant to sub-clause
        4.4.2(b) of Clause 4.4 (Conditions
        relating to Optional Currencies)
    or, if less, the Available Facility.  
	 
	5.4  	Lenders' participation 
	 	5.4.1  	If the conditions set
        out in this Agreement have been met, each Lender shall make its participation
        in each Loan available by the Utilisation Date through its Facility Office.  
	 
	 	5.4.2  	Subject to Clause 8.3
        (Revocation of Currency),
        the amount of each Lender's participation in each Loan (not being a Swingline
        Loan) will be equal to the proportion borne by its Available Commitment
        to the Available Facility immediately prior to making the Loan.  
	 
	 	5.4.3  	The Facility Agent shall
        determine the Base Currency Amount of each Revolving Loan which is to
        be made in an Optional Currency and shall notify each Revolving Lender
        of the amount, currency and the Base Currency Amount of each Revolving
        Loan and the amount of its participation in that Revolving Loan, in each
        case by the Specified Time.  
	 
	6.  	UTILISATION - SWINGLINE
          LOANS 
	 
	6.1  	General 
	 	6.1.1  	In this Clause and Clause
        7 (Swingline Loans):  
	 
	 	 	(a)  	"Available
          Swingline Commitment" of a Swingline
          Lender means (but without limiting sub-clause 6.4.5 of Clause 6.4 (Swingline Lenders' participation)
          and Clause 6.5 (Relationship with
          Revolving Facility)) that Lender's
          Swingline Commitment minus:  
	 
	 	 	 	(i)  	the Base Currency Amount of its participation
        in any outstanding Swingline Loans; and  
	 
	 	 	 	(ii)  	in relation to any proposed Utilisation under
        the Swingline Facility, the Base Currency Amount of its participation
        in any Swingline Loans that are due to be made under the Swingline Facility
        on or before the proposed Utilisation Date,  
	 
	 	 	 	other than that Lender's
        participation in any Swingline Loans that are due to be repaid or prepaid
        on or before the proposed Utilisation Date.  
	 
	 	 	(b)  	"Available
          Swingline Facility" means the
          aggregate for the time being of each Swingline Lender's Available Swingline
          Commitment.  
	 
	 	 	(c)  	"Euro
          Swingline Business Day" means
          any TARGET Day which is also a Business Day.  

 - 26 -

	 	 	(d)  	"Euro
          Swingline Rate" means, in relation
          to a Euro Swingline Loan, the percentage rate per annum which is the
          aggregate of:  
	 
	 	 	 	(i)  	the arithmetic mean of the rates (rounded upwards
        to four decimal places) as supplied to the Euro Swingline Agent at its
        request quoted by the Reference Banks to leading banks in the European
        interbank market as at the time the Euro Swingline Agent notifies the
        relevant Swingline Lenders of details of the participation of the relevant
        Swingline Lender in accordance with sub-clause 6.4.4 of Clause 6.4 (Swingline
        Lenders' participation) on the Utilisation
        Date for that Euro Swingline Loan for the offering of deposits in euro
        for a period comparable to the Interest Period for the relevant Euro
        Swingline Loan and for settlement on that day;  
	 
	 	 	 	(ii)  	the Margin; and  
	 
	 	 	 	(iii)  	Mandatory Cost (if any).  
	 
	 	 	 	For the purposes of this
        Clause, the Reference Banks are the principal offices in London of Citibank
        International plc, Barclays Bank PLC and The Royal Bank of Scotland plc
        or such other banks as may be appointed by the Euro Swingline Agent in
        consultation with the Company.  
	 
	 	 	(e)  	"Federal
          Funds Rate" means, in relation
          to any day, the rate per annum equal to:  
	 
	 	 	 	(i)  	the weighted average of the rates on overnight
        Federal funds transactions with members of the US Federal Reserve System
        arranged by Federal funds brokers, as published for that day (or, if
        that day is not a New York Business Day, for the immediately preceding
        New York Business Day) by the Federal Reserve Bank of New York; or  
	 
	 	 	 	(ii)  	if a rate is not so published for any day which
        is a New York Business Day, the average of the quotations for that day
        on such transactions received by the Dollar Swingline Agent from three
        Federal funds brokers of recognised standing selected by the Dollar Swingline
        Agent.  
	 
	 	 	(f)  	"New
          York Business Day" means a day
          (other than a Saturday or Sunday) on which banks are open for general
          business in New York City.  
	 
	 	 	(g)  	"Overall
          Commitment" of a Lender means:  
	 
	 	 	 	(i)  	its Revolving Facility Commitment; or  
	 
	 	 	 	(ii)  	in the case of a Swingline Lender which does
        not have a Revolving Facility Commitment, the Revolving Facility Commitment
        of a Lender which is its Affiliate.  

 - 27 -

	 	 	(h)  	"Total
          Swingline Commitments" means the
    aggregate of the Swingline Commitments, being US$ 250,000,000
    at the date of this Agreement.  
	 	 
	 	 	 	For the avoidance of doubt, the amounts
        set out in Part IV of Schedule 1 (The
        Original Parties) aggregate to form
        the Total Swingline Commitments and the amounts set out in Part V of
        Schedule 1 (The Original Parties)
        aggregate to form the Total Swingline Commitments, however amounts under
        both Part IV and Part V of Schedule 1 (The
        Original Parties) do not aggregate
    to form the Total Swingline Commitments.  
	 
	 	6.1.2  	Any reference in this
        Agreement to:  
	 
	 	 	(a)  	an "Interest
          Period" includes each period determined
          under this Agreement by reference to which interest on a Swingline
          Loan is calculated; and  
	 
	 	 	(b)  	a "Lender" includes
        a Dollar Swingline Lender, and a Euro Swingline Lender unless the context
        otherwise requires.  
	 
	 	6.1.3  	
	 
	 	 	(a)  	Clauses 4.3 (Further
          conditions precedent) and 4.4
          (Conditions relating to optional
          currencies);  
	 
	 	 	(b)  	Clause 5 (Utilisation
          - Procedure);  
	 
	 	 	(c)  	Clause 8 (Selection
          of currencies);  
	 
	 	 	(d)  	Clause 15 (Interest)
        as it applies to the calculation of interest on a Loan but not default
        interest on an overdue amount; and  
	 
	 	 	(e)  	Clause 17 (Changes
          to the calculation of interest),  
	 
	 	 	do not apply to Swingline Loans.  
	 
	6.2  	Delivery of a Utilisation
          Request for Swingline Loans 
	 
	 	6.2.1  	A Borrower may utilise
        the Swingline Facility by delivery by it (or the Company on behalf of
        a Borrower) to the relevant Swingline Agent (copied to the Facility Agent)
        of a duly completed Utilisation Request in the form of Part II of Schedule
        3 (Requests)
        not later than the Specified Time.  
	 
	 	6.2.2  	Each Utilisation Request:  
	 
	 	 	(a)  	for a Dollar Swingline Loan must be sent to
        the Dollar Swingline Agent to the address in New York notified by the
        Dollar Swingline Agent for this purpose;  
	 
	 	 	(b)  	for a Euro Swingline Loan must be sent to the
        Euro Swingline Agent to the address in London notified by the Euro Swingline
        Agent for this purpose.  

 - 28 -

	6.3  	Completion of a Utilisation
          Request for Swingline Loans 
	 	 	6.3.1  	Each Utilisation Request
        for a Swingline Loan is irrevocable and will not be regarded as having
        been duly completed unless:  
	 
	 	 	 	(a)  	it identifies the Borrower;  
	 
	 	 	 	(b)  	it specifies that it is
        for a Dollar Swingline Loan, or a Euro Swingline Loan;  
	 
	 	 	 	(c)  	the proposed Utilisation
        Date is:  
	 
	 	 	 	 	(i)  	in relation to a Dollar Swingline Loan, is
        a New York Business Day; and  
	 
	 	 	 	 	(ii)  	in relation to a Euro Swingline Loan, is a
        Euro Swingline Business Day;  
	 
	 	 	 	 	within the Availability Period applicable to
    the Revolving Facility;  
	 
	 	 	 	(d)  	the Swingline Loan is:  
	 
	 	 	 	 	(i)  	in relation to a Dollar Swingline Loan denominated
        in U.S. Dollars; and  
	 
	 	 	 	 	(ii)  	in relation to a Euro Swingline Loan denominated
        in Euros;  
	 
	 	 	 	(e)  	the amount of the proposed
        Swingline Loan is an amount whose Base Currency Amount is not more than
        the Available Swingline Facility and is a minimum of US$10,000,000
        or, if less, the Available Swingline Facility; and  
	 
	 	 	 	(f)  	the proposed Interest
        Period:  
	 
	 	 	 	 	(i)  	does not overrun the Revolving Facility Maturity
        Date;  
	 
	 	 	 	 	(ii)  	is a period of not more than five New York
        Business Days (in relation to a Dollar Swingline Loan) or five Euro Swingline
        Business Days (in relation to a Euro Swingline Loan); and  
	 
	 	 	 	 	(iii)  	ends on a New York Business Day (in relation
        to a Dollar Swingline Loan) or a Euro Swingline Business Day (in relation
        to a Euro Swingline Loan).  
	 
	 	 	6.3.2  	Only one Swingline Loan
        may be requested in each Utilisation Request.  
	 
	6.4  	Swingline Lenders'
          participation 
	 	 	6.4.1  	If the conditions set
        out in this Agreement have been met, each Swingline Lender shall make
        its participation in each Swingline Loan available through its relevant
        Facility Office.  
	 
	 	 	6.4.2  	The Swingline Lenders
        will only be obliged to comply with sub-clause 6.4.1 above if on the
        date of the Utilisation Request and on the proposed Utilisation Date:  
	 
	 	 	 	(a)  	no Default is continuing
        or would result from the proposed Utilisation; and  

 - 29 -

	 	 	 	(b)  	the Repeating Representations
        to be made by each Obligor are true in all material respects.  

	 	6.4.3  	The amount of each Swingline
        Lender's participation in each Swingline Loan will be equal to the proportion
        borne by its Available Swingline Commitment to the Available Swingline
        Facility immediately prior to making the Swingline Loan, adjusted to
        take account of any limit applying under Clause 6.5 (Relationship
        with Revolving Facility).  
	 
	 	6.4.4  	The relevant Swingline
        Agent shall determine the Base Currency Amount of each relevant Swingline
        Loan and notify each relevant Swingline Lender of the amount of each
        relevant Swingline Loan and its participation in that relevant Swingline
        Loan by the Specified Time.  
	 
	 	6.4.5  	Utilisation by a Borrower
        of the Euro Swingline Facility shall reduce the Available Swingline Commitment
        in respect of the Dollar Swingline Facility rateably by an amount equivalent
        to the Base Currency Amount of that Utilisation, Utilisation by a Borrower
        of the Dollar Swingline Facility shall reduce the Available Swingline
        Commitment in respect of the Euro Swingline Facility rateably by an amount
        equivalent to the Base Currency Amount of that Utilisation.  
	 
	6.5  	Relationship with Revolving
          Facility 
	 	6.5.1  	This Clause applies when
        a Swingline Loan is outstanding or is to be borrowed.  
	 
	 	6.5.2  	The Revolving Facility
        may be used by way of Swingline Loans. The Swingline Facility is not
        independent of the Revolving Facility.  
	 
	 	6.5.3  	Notwithstanding any other
        term of this Agreement a Lender is only obliged to participate in a Revolving
        Loan or a Swingline Loan to the extent that it would not result in the
        Base Currency Amount of its participation and that of a Lender which
        is its Affiliate in the Revolving Loans, the Dollar Swingline Loans,
        and the Euro Swingline Loans exceeding its Overall Commitment.  
	 
	 	6.5.4  	Where, but for the operation
        of sub-clause 6.5.3 above, the Base Currency Amount of a Lender's participation
        and that of a Lender which is its Affiliate in the Revolving Loans, the
        Dollar Swingline Loans, and the Euro Swingline Loans would have exceeded
        its Overall Commitment, the excess will be apportioned among the other
        Lenders participating in the relevant Loan pro
        rata according to their relevant
        Commitments. This calculation will be applied as often as necessary until
        the Loan is apportioned among the relevant Lenders in a manner consistent
        with sub-clause 6.5.3 above.  
	 
	 	6.5.5  	The amount of a proposed
        Dollar Swingline Loan or, as the case may be, the Base Currency Amount
        of a proposed Euro Swingline Loan must not, when aggregated with the
        Base Currency Amount of all outstanding Swingline Loans, exceed the Total
        Swingline Commitments.  

 - 30 -

	 	 	 	 
	7.  	SWINGLINE LOANS 
	 
	7.1  	Swingline 
	 	Subject to the terms of
        this Agreement, the Swingline Lenders make available to the Borrowers
        a swingline loan facility comprising:  
	 
	 	7.1.1  	a dollar swingline loan
        facility in an aggregate amount equal to the Total Swingline Commitments;
        and  
	 
	 	7.1.2  	a euro swingline loan
        facility in an aggregate amount equal to the euro equivalent of the Total
        Swingline Commitments.  
	 
	7.2  	Purpose 
	 	Each Borrower shall apply
        all amounts borrowed by it under each of the Dollar Swingline Facility,
        and the Euro Swingline Facility towards short-term general corporate
        borrowings. A Swingline Loan may not be applied in repayment or prepayment
        of another Swingline Loan.  
	 
	7.3  	Repayment 
	 	7.3.1  	Each Borrower that has
        drawn a Swingline Loan shall repay that Swingline Loan on the last day
        of its Interest Period.  
	 
	 	7.3.2  	If a Swingline Loan is
        not repaid in full on its due date and the repayment of which is not
        otherwise funded under the Revolving Facility, the relevant Swingline
        Agent shall (if requested to do so in writing by any affected Swingline
        Lender) set a date (the "Loss Sharing
        Date") on which payments shall be
        made between the Lenders to re-distribute the unpaid amount between them.
        The relevant Swingline Agent shall give at last 3 Business Days notice
        to each affected Lender of the Loss Sharing Date and notify it of the
        amounts to be paid or received by it.  
	 
	 	7.3.3  	On the Loss Sharing Date
        each Lender must pay to the relevant Swingline Agent its proportion of
        the Unpaid Amount minus its (or its Affiliate's) Unpaid Swingline Participation
        (if any). If this produces a negative figure for a Lender no amount need
        be paid by that Lender.  
	 
	 	 	The "Proportion" of
        a Lender means the proportion borne by:  
	 
	 	 	(a)  	its Revolving Facility Commitment (or, if the
        Total Revolving Facility Commitments are then zero, its Revolving Facility
        Commitment immediately prior to their reduction to zero) minus the Base
        Currency Amount of its participation (or that of a Lender which is its
        Affiliate) in any outstanding Revolving Loans (but ignoring its (or its
        Affiliate's) participation in the unpaid Swingline Loan): to  
	 
	 	 	(b)  	the Total Revolving Facility Commitments (or,
        if the Total Revolving Facility Commitments are then zero, the Total
        Revolving Facility Commitments immediately prior to their reduction to
        zero) minus any outstanding Revolving Loans (but ignoring the unpaid
        Swingline Loan).  

 - 31 -

	 	 	The "Unpaid
          Amount" means, in relation to
          a Swingline Loan, any principal not repaid and/or any interest accrued
          but unpaid on that Swingline Loan calculated from the Utilisation Date
    to the Loss Sharing Date.  
	 
	 	 	The "Unpaid
          Swingline Participation" of a
          Lender means that part of the Unpaid Amount (if any) owed to that Lender
          (or its Affiliate) (before any redistribution under this Clause 7.3
    (Repayment)).  
	 
	 	7.3.4  	Out of the funds received
        by the relevant Swingline Agent pursuant to sub-clause 7.3.3 the relevant
        Swingline Agent shall pay to each Swingline Lender an amount equal to
        the Shortfall (if any) of that Swingline Lender where:  
	 
	 	 	The "Shortfall" of
        a Swingline Lender is an amount equal to its Unpaid Swingline Participation
        minus its (or its Affiliate's) Proportion of the Unpaid Amount.  
	 
	 	7.3.5  	If the amount actually
        received by the relevant Swingline Agent from the Lenders is insufficient
        to pay the full amount of the Shortfall of all Dollar Swingline Lenders
        or, as the case may be, all Euro Swingline Lenders then the amount actually
        received will be distributed amongst the Dollar Swingline Lenders or,
        as the case may be, all Euro Swingline Lenders pro
        rata to the Shortfall of each Dollar
        Swingline Lender or, as the case may be, Euro Swingline Lender.  
	 
	 	7.3.6  	
	 
	 	 	(a)  	On a payment under this paragraph, the paying
        Lender will be subrogated to the rights of the Swingline Lenders which
        have shared in the payment received.  
	 
	 	 	(b)  	If and to the extent a paying Lender is not
        able to rely on its rights under sub- paragraph (a) above, the relevant
        Borrower shall be liable to the paying Lender for a debt equal to the
        amount the paying Lender has paid under this paragraph.  
	 
	 	 	(c)  	Any payment under this paragraph does not reduce
        the obligations in aggregate of any Obligor.  
	 
	7.4  	Voluntary Prepayment
          of Swingline Loans 
	 
	 	7.4.1  	The Borrower to which
        a Swingline Loan has been made may prepay at any time the whole of that
        Swingline Loan.  
	 
	 	7.4.2  	Unless a contrary indication
        appears in this Agreement, any part of the Swingline Facility which is
        prepaid may be reborrowed in accordance with the terms of this Agreement.  
	 
	7.5  	Interest 
	 
	 	7.5.1  	The rate of interest on
        each Dollar Swingline Loan for any day during its Interest Period is
        the higher of:  
	 
	 	 	(a)  	the prime commercial lending rate in U.S. Dollars
        announced by the Dollar Swingline Agent at the Specified Time and in
        force on that day; and  

 - 32 -

	 	 	(b)   	0.5 per cent. per annum over the
        rate per annum determined by the Dollar Swingline Agent to be
        the Federal Funds Rate (as published by the Federal Reserve Bank of New
        York) for that day.  
	 
	 	7.5.2  	The rate of interest on
        each Euro Swingline Loan for its Interest Period is the Euro Swingline
        Rate.  
	 
	 	7.5.3  	The Dollar Swingline Agent,
        or as the case may be the Euro Swingline Agent, shall promptly notify
        the Dollar Swingline Lenders or, as the case may be, the Euro Swingline
        Lenders and the relevant Borrower of the determination of the rate of
        interest under sub-clauses 7.5.1 or 7.5.2 above.  
	 
	 	7.5.4  	If any day during an Interest
        Period for a Dollar Swingline Advance is not a New York Business Day,
        the rate of interest on such Dollar Swingline Loan on that day will be
        the rate applicable to the immediately preceding New York Business Day.  
	 
	 	7.5.5  	Each Borrower shall pay
        accrued interest on each Swingline Loan made to it on the last day of
        its Interest Period.  
	 
	7.6  	Interest Period 
	 	7.6.1  	Each Swingline Loan has
        one Interest Period only.  
	 
	 	7.6.2  	The Interest Period for
        a Swingline Loan must be selected in the relevant Utilisation Request.  
	 
	7.7  	Dollar Swingline Agent,
          Euro Swingline Agent 
	 	7.7.1  	Each Swingline Agent may
        perform its duties in respect of the Dollar Swingline Facility, or the
        Euro Swingline Facility as the case may be, through an Affiliate or Affiliates
        acting as its agent.  
	 
	 	7.7.2  	Notwithstanding any other
        term of this Agreement and without limiting the liability of any Obligor
        under the Finance Documents, each Euro Swingline Lender shall (in proportion
        to its share of the Total Swingline Commitments or, if the Total Swingline
        Commitments are then zero, to its share of the Total Swingline Commitments
        immediately prior to their reduction to zero) pay to or indemnify the
        Euro Swingline Agent, within three Business Days of demand, for or against
        any cost, loss or liability incurred by the Euro Swingline Agent or any
        Affiliate of the Euro Swingline Agent (other than by reason of the Euro
        Swingline Agent's or such Affiliate's gross negligence or wilful misconduct)
        in acting as the Euro Swingline Agent (unless the Euro Swingline Agent
        or such Affiliate has been reimbursed by an Obligor pursuant to this
        Agreement).  
	 
	 	7.7.3  	Notwithstanding any other
        term of this Agreement and without limiting the liability of any Obligor
        under the Finance Documents, each Dollar Swingline Lender shall (in proportion
        to its share of the Total Swingline Commitments or, if the Total Swingline
        Commitments are then zero, to its share of the Total Swingline Commitments
        immediately prior to their reduction to zero) pay to or indemnify the
        Dollar Swingline Agent, within three Business Days of demand, for or
        against any  

 - 33 -

	 	 	cost, loss or liability incurred by the Dollar
        Swingline Agent or any Affiliate of the Dollar Swingline Agent (other
        than by reason of the Dollar Swingline Agent's or such Affiliate's gross
        negligence or wilful misconduct) in acting as the Dollar Swingline Agent
        (unless the Dollar Swingline Agent or such Affiliate has been reimbursed
    by an Obligor pursuant to this Agreement).  
	 
	7.8  	Conditions of assignment
          or transfer 
	 	Notwithstanding any other
        term of this Agreement, each Lender shall ensure that at all times its
        Overall Commitment is not less than:  
	 
	 	7.8.1  	its Swingline Commitment; or  
	 
	 	7.8.2  	if it does not have a Swingline Commitment,
        the Swingline Commitment of a Lender which is its Affiliate.  
	 
	8.  	SELECTION OF CURRENCIES 
	 
	8.1  	Availability of Optional
          Currencies 
	 	A Borrower may request
        that a Revolving Loan be denominated in an Optional Currency in accordance
        with the provisions of Clause 4.4 (Conditions
        relating to Optional Currencies).  
	 
	8.2  	Selection 
	 	8.2.1  	A Borrower (or the Company on behalf of a Borrower)
        may select the currency of a Revolving Loan for an Interest Period in
        the relevant Utilisation Request.  
	 
	 	8.2.2  	The Facility Agent shall notify each Revolving
        Lender of the proposed currency or currencies of each Revolving Loan
        promptly after it is ascertained.  
	 
	8.3  	Revocation of currency 
	 
	 	Notwithstanding Clause
        8.1 (Availability of Optional Currencies)
        and without prejudice to Clause 17.2 (Market
        disruption) or Clause 11.1 (Illegality),
        if before the Specified Time on any Quotation Day, the Facility Agent
        receives notice from a Revolving Lender that:  
	 
	 	8.3.1  	the Optional Currency (other than sterling
        or euro) requested is not readily available to it in the amount required;
        or  
	 
	 	8.3.2  	compliance with its obligation to participate
        in the Revolving Loan in the proposed Optional Currency would contravene
        a law or regulation applicable to it,  
	 
	 	the Facility Agent shall
        give notice to the relevant Borrower and to the Revolving Lenders to
        that effect before the Specified Time on that day. In this event, any
        Revolving Lender that gives notice pursuant to this Clause 8.3 (Revocation
        of currency) will be required to
        participate in the Revolving Loan in the Base Currency (in an amount
        equal to that Revolving Lender's proportion of the Base Currency Amount
        of the Loan that is due to be made) and its participation will be treated
        as a separate Revolving Loan denominated in the Base Currency during
        that Interest Period.  

 - 34 -

	9.  	AMOUNT OF OPTIONAL CURRENCIES 
	 
	9.1  	Drawdowns 
	 	If a Revolving Loan is to be drawn down in
        an Optional Currency, the amount of each Revolving Lender's participation
        in that Revolving Loan will be determined by converting into that currency
        the Revolving Lender's participation in the Base Currency Amount of that
        Revolving Loan.  
	 
	9.2  	Notification 
	 	The Facility Agent shall notify the Revolving
        Lenders and the Company of Optional Currency amounts (and the applicable
        Facility Agent's Spot Rate of Exchange) promptly after they are ascertained.  

 - 35 -

 SECTION 4

REPAYMENT, PREPAYMENT, CANCELLATION
AND EXTENSION

	 	 	 
	10.  	REPAYMENT 
	 
	10.1  	Repayment of Term Loans 
	 
	 	10.1.1  	The Borrowers under Facility A shall repay
        the aggregate Facility A Loans in instalments by repaying on each Facility
        A Repayment Date the amount set out opposite that Facility A Repayment
        Date below:  

	 	 	 	 	 
	 	 	Facility A Repayment
    Date (Months after date	 	Repayment Instalment 
	 	 	of this Agreement)	 	 
	 	 	12 months  	 	US$150,000,000  
	 	 	24months  	 	US$150,000,000  
	 	 	36 months  	 	US$200,000,000  
	 	 	48 months  	 	US$200,000,000  
	 	 	Facility A Maturity Date  	 	Balance of Facility A
        Loan  

	 	10.1.2  	The Borrowers under Facility B shall repay
        the aggregate Facility B Loan in full on the Facility B Maturity Date.  
	 
	10.2  	Effect of cancellation
          and prepayment on scheduled repayments and reductions 
	 	10.2.1  	If any of the Facility A Loans are prepaid
        in accordance with Clause 11.3 (Voluntary
        Prepayment of Loans) and the aggregate
        amount of the Facility A Loans made to the Borrower exceeds the amount
        of the prepayments, the Company may, if it gives the Agent not less than
        five Business Days' notice (or such shorter period as the Majority Lenders
        may agree) select which of those outstanding Facility A Loans and Repayment
        Instalments will be wholly or partially prepaid. If the Company fails
        to deliver such notice the Agent shall select the Facility A Loans and
        Repayment Instalments to be wholly or partially prepaid.  
	 
	 	10.2.2  	If any of the Facility A Loans are prepaid
        in accordance with Clause 12.2 (Mandatory
        prepayment and cancellation out of certain proceeds)
        then the amount of the Repayment Instalment for each Facility A Repayment
        Date will reduce in inverse chronological order by the amount of the
        Facility A Loan repaid.  
	 
	10.3  	Repayment of Revolving
          Loans 
	 	Each Borrower which has
        drawn a Revolving Loan shall repay that Revolving Loan on the last day
        of its Interest Period.  
	 
	11.  	ILLEGALITY, VOLUNTARY
          PREPAYMENT AND CANCELLATION 
	 
	11.1  	Illegality 
	 	If it becomes unlawful
        in any applicable jurisdiction for a Lender to perform any of its obligations
        as contemplated by this Agreement or to fund or maintain its participation
        in any  

 - 36 -

	 	 	 	 
	 	Loan, that Lender shall
        promptly notify the Facility Agent upon becoming aware of that event
        and shall also notify the Facility Agent that it requires either or both
        of the following:  
	 
	 	11.1.1  	upon the Facility Agent
        notifying the Company, the Commitment of that Lender will be immediately
        cancelled; and/or  
	 
	 	11.1.2  	each Borrower shall repay
        that Lender's participation in the Loans made to that Borrower on the
        last day of the Interest Period for each Loan occurring after the Facility
        Agent has notified the Company or, if earlier, the date specified by
        the Lender in the notice delivered to the Facility Agent (being no earlier
        than the last day of any applicable grace period permitted by law).  
	 
	11.2  	Voluntary cancellation 
	 	The Company may, if it
        gives the Facility Agent not less than five Business Days' (or such shorter
        period as the Majority Lenders may agree) prior notice, cancel the whole
        or any part (being a minimum amount of US$10,000,000) of an Available
        Facility. Any cancellation under this Clause 11.2 shall reduce the Commitments
        of the Lenders rateably under the relevant Facility. If, as a result
        of any cancellation of the Available Revolving Facility in relation to
        the Revolving Facility, the Total Commitments in relation to the Revolving
        Facility would be less than the Total Swingline Commitments then the
        amount of the Total Swingline Commitments shall reduce so that they equal
        the Total Revolving Facility Commitments. Any such cancellation of the
        Total Swingline Commitments shall reduce the Swingline Commitments of
        the Lenders rateably.  
	 
	11.3  	Voluntary Prepayment
          of Loans 
	 	The Borrower to which
        a Loan has been made may, if it gives the Facility Agent not less than
        five Business Days' (or such shorter period as the Majority Lenders may
        agree) prior notice, prepay the whole or any part of a Loan (but if in
        part, being an amount that reduces the Base Currency Amount of the Loan
        by a minimum amount of US$10,000,000).  
	 
	11.4  	Right of repayment
          and cancellation in relation to a single Lender 
	 	11.4.1  	If:  
	 
	 	 	(a)  	any sum payable to any Lender by an Obligor
        is required to be increased under sub-clause 19.2.4 of Clause 19.2 (Tax
        gross-up); or  
	 
	 	 	(b)  	the Company receives a demand from the Facility
        Agent under Clause 19.3 (Tax indemnity)
        or Clause 20.1 (Increased costs),  
	 
	 	 	the Company may, while
        the circumstance under paragraph (a) above or the circumstance giving
        rise to the notice under paragraph (b) above continues, give the Facility
        Agent notice of cancellation of the Commitment of that Lender and its
        intention to procure the repayment of that Lender's participation in
        the Loans.  
	 
	 	11.4.2  	On receipt of a notice
        from the Company referred to in sub-clause 11.4.1 above the Commitment
        of that Lender shall immediately be reduced to zero.  
	 
	 	11.4.3  	On the last day of each
        Interest Period which ends after the Company has given notice under sub-clause
        11.4.1 above (or, if earlier, the date specified by the  

 - 37 -

	 	 	Company in that notice), each Borrower
        to which a Loan is outstanding shall repay that Lender's participation
    in that Loan.  
	 
	12.  	MANDATORY PREPAYMENT 
	 
	12.1  	Mandatory Prepayment
          on Change of control 
	 	12.1.1  	If any person or group
        of persons acting in concert gains control of the Company:  
	 
	 	 	(a)  	the Company shall promptly notify the Facility
        Agent upon becoming aware of that event;  
	 
	 	 	(b)  	a Lender shall not be obliged to fund a Utilisation
        (except for a Rollover Loan); and  
	 
	 	 	(c)  	if a Lender so requires, the Facility Agent
        shall, by not less than 30 days notice to the Company, cancel that Lender's
        Available Commitments and declare all outstanding Loans due to such Lender,
        together with accrued interest, and all other amounts accrued under the
        Finance Documents immediately due and payable, whereupon that Lender's
        Available Commitment will be cancelled and all such outstanding amounts
        will become immediately due and payable.  
	 
	 	12.1.2  	For the purpose of sub-clause
        12.1.1 above "control" means:  
	 
	 	 	(a)  	the power (whether by way of ownership of shares,
        proxy, contract, agency or otherwise) to cast, or control the casting
        of, more than one-half of the maximum number of votes that may be cast
        at a general meeting of the Company; or  
	 
	 	 	(b)  	the holding of more than one-half of the issued
        share capital of the Company (excluding any part of that issued share
        capital that carries no right to participate beyond a specified amount
        in a distribution of either profits or capital).  
	 
	 	12.1.3  	For the purpose of sub
        clause 12.1.1 above "acting in concert" means,
        a group of persons who, pursuant to an agreement or understanding (whether
        formal or informal), actively co-operate, through the acquisition by
        any of them, either directly or indirectly, of shares in the Company,
        to obtain or consolidate control of the Company.  
	 
	12.2  	Mandatory prepayment
          and cancellation out of certain proceeds 
	 	12.2.1  	The Company shall ensure
        that:  
	 
	 	 	(a)  	all Disposal Proceeds and all Acquisition Proceeds
        are applied in prepayment and cancellation of the Facilities in accordance
        with sub-clause 12.2.2 below; and  
	 
	 	 	(b)  	until such time as the Total Revolving Facility
        Commitments have been reduced to US$500,000,000 and all amounts outstanding
        under or in respect of  

 - 38 -

	 	 	 	Facility A and Facility B have been repaid
        in full, and to the extent necessary to reduce the Total Revolving Facility
        Commitments to US$500,000,000, all Debt Proceeds are applied in prepayment
        and cancellation of the Facilities in accordance with sub-clause 12.2.2
    below.  
	 	 	 
	 	12.2.2  	Any amount to be applied
        in prepayment and cancellation of the Facilities in accordance with sub-clause
        12.2.1 above shall be applied in the following order:  
	 
	 	 	(a)  	firstly, in cancellation of the Available Commitments
        under the Term Loans (first in cancellation of any Available Commitments
        under Facility B and then in cancellation of any Available Commitments
        under Facility A);  
	 
	 	 	(b)  	secondly, in prepayment of the Term Loans as
        contemplated in sub-clause 12.2.3 below;  
	 
	 	 	(c)  	thirdly, in cancellation of Available Commitments
        under the Revolving Facility (and the Available Commitments of the Revolving
        Lenders under the Revolving Facility shall be cancelled rateably); and  
	 
	 	 	(d)  	fourthly, in prepayment of Revolving Loans
        and Revolving Facility Commitments.  
	 
	 	12.2.3  	A prepayment under sub-clause
        12.2.1 shall prepay the Term Loans as follows:  
	 
	 	 	(a)  	in prepayment of the Facility B Loans, and,
        when all amounts outstanding under Facility B have been prepaid, in prepayment
        of the Facility A Loans; and  
	 
	 	 	(b)  	in relation to prepayment of Facility A Loans,
        reducing the Repayment Instalment for each Facility A Repayment Date
        falling after the date of the prepayment in inverse chronological order.  
	 
	 	12.2.4  	If a date for prepayment
        of a Loan falls otherwise than on the last day of an Interest Period,
        such prepayment may be made on the last day of that Loan's then current
        Interest Period.  
	 
	 	12.2.5  	If, as a result of any
        cancellation of Available Commitments or Commitments in accordance with
        sub-clause 12.2.2 above the Total Commitments in relation to Facility
        A would be less than the Total Swingline Commitments then the amount
        of the Total Swingline Commitments shall reduce so that they equal the
        Total Commitments in relation to Facility A.  
	 
	 	12.2.6  	Any cancellation of the
        Total Commitments in relation to any Facility shall reduce the relevant
        Commitments of the Lenders participating in such Facility rateably.  
	 
	13.  	RESTRICTIONS 
	 
	13.1  	Notices of Cancellation
          and Prepayment 
	 	Any notice of cancellation
        or prepayment given by any Party under this Clause 13 shall be irrevocable
        and, unless a contrary indication appears in this Agreement, shall specify
        the  

 - 39 -

	 	date or dates upon which the relevant cancellation
        or prepayment is to be made and the amount of that cancellation or prepayment.  
	 
	13.2  	Interest and other amounts 
	 	Any prepayment under this Agreement shall be
        made together with accrued interest on the amount prepaid and, subject
        to any Break Costs, without premium or penalty.  
	 
	13.3  	No reborrowing of Term Loan 
	 	No Borrower may reborrow any part of a Term
        Loan which is prepaid.  
	 
	13.4  	Reborrowing of Revolving Facility 
	 	Unless a contrary indication appears in this
        Agreement, any part of a Revolving Facility which is prepaid may be reborrowed
        in accordance with the terms of this Agreement.  
	 
	13.5  	Prepayment in accordance with Agreement 
	 	The Borrowers shall not repay or prepay all
        or any part of the Loans or cancel all or any part of the Commitments
        except at the times and in the manner expressly provided for in this
        Agreement.  
	 
	13.6  	No reinstatement of Commitments 
	 	No amount of the Total Commitments cancelled
        under this Agreement may be subsequently reinstated.  
	 
	13.7  	Facility Agent's receipt of Notices 
	 	If the Facility Agent receives a notice under
        this Clause 13 it shall promptly forward a copy of that notice to either
        the Company or the affected Lender, as appropriate.  
	 
	14.  	EXTENSION OF FACILITY B 
	 
	14.1  	Extension Notice 
	 	The Company shall be entitled to extend Facility
        B, for an additional period of 364 days. This right may be exercised
        by giving notice to the Facility Agent (the "Extension
        Notice") not more than 60 nor less
        than 30 days before the Facility B Maturity Date (in this Clause 14,
        the "Original Facility B Maturity
        Date"). Such notice shall be made in writing, be unconditional and binding
        on the Borrower.  
	 
	14.2  	Notification of Extension Notice 
	 	The Facility Agent shall forward a copy of
        the Extension Notice to the relevant Lenders as soon as practicable after
        receipt of it.  
	 
	14.3  	Extension Date 
	 	Following delivery of an Extension Notice pursuant
        to Clause 14.1 above, the Original Facility B Maturity Date shall be
        extended to the day which is 364 days from (and including) the Original
        Facility B Maturity Date and the Facility B Maturity Date shall be modified
        accordingly.  
	 
	14.4  	Extension options 
	 	A Company may not extend the Facility B Maturity
        Date in accordance with this Agreement more than once.  

 - 40 -

 SECTION 5

    COSTS OF UTILISATION

	 	 	 	 
	15.  	INTEREST 
	 
	15.1  	Calculation of interest 
	 	The rate of interest on
        each Loan for each Interest Period is the percentage rate per annum which
        is the aggregate of the applicable:  
	 
	 	15.1.1  	Margin;  
	 
	 	15.1.2  	LIBOR; and  
	 
	 	15.1.3  	Mandatory Cost, if any.  
	 
	15.2  	Payment of interest 
	 	The Borrower to which
        a Loan has been made shall pay accrued interest on that Loan on the last
        day of each Interest Period (and, if the Interest Period is longer than
        six Months, on the dates falling at six Monthly intervals after the first
        day of the Interest Period).  
	 
	15.3  	Default interest 
	 	15.3.1  	If an Obligor fails to
        pay any amount payable by it under a Finance Document on its due date,
        interest shall accrue on the overdue amount from the due date up to the
        date of actual payment (both before and after judgment) at a rate which,
        subject to sub-clause 15.3.2 below, is one per cent. higher than the
        rate which would have been payable if the overdue amount had, during
        the period of non-payment, constituted a Loan in the currency of the
        overdue amount for successive Interest Periods, each of a duration selected
        by the Facility Agent (acting reasonably). Any interest accruing under
        this Clause 15.3 shall be immediately payable by the Obligor on demand
        by the Facility Agent.  
	 
	 	15.3.2  	If any overdue amount
        consists of all or part of a Loan which became due on a day which was
        not the last day of an Interest Period relating to that Loan:  
	 
	 	 	(a)  	the first Interest Period for that overdue
        amount shall have a duration equal to the unexpired portion of the current
        Interest Period relating to that Loan; and  
	 
	 	 	(b)  	the rate of interest applying to the overdue
        amount during that first Interest Period shall be one per cent. higher
        than the rate which would have applied if the overdue amount had not
        become due.  
	 
	 	15.3.3  	Default interest (if unpaid)
        arising on an overdue amount will be compounded with the overdue amount
        at the end of each Interest Period applicable to that overdue amount
        but will remain immediately due and payable.  
	 
	15.4  	Notification of rates
          of interest 
	 	The Facility Agent shall
        promptly notify the Lenders and the Company of the determination of a
        rate of interest under this Agreement.  

 - 41 -

	16.  	INTEREST PERIODS 
	 
	16.1  	Selection of Interest
          Periods 
	 	16.1.1  	A Borrower (or the Company on behalf of a Borrower)
        may select an Interest Period for a Loan in the Utilisation Request for
        that Loan.  
	 
	 	16.1.2  	Subject to this Clause 16, a Borrower (or the
        Company) may select an Interest Period of one week, one, two, three or
        six Months or any other period agreed between the Company and the Facility
        Agent (acting on the instructions of all the Lenders), provided
        that the Borrowers (or the Company)
        may select a maximum of 5 one week interest periods in aggregate per
        year.  
	 
	 	16.1.3  	Prior to the Syndication Date, Interest Periods
        shall be one Month or such shorter period as agreed between the Company
        and the Facility Agent (acting on the instructions of the Lenders).  
	 
	 	16.1.4  	An Interest Period for a Loan shall not extend
        beyond the Maturity Date applicable to its Facility.  
	 
	16.2  	Overrunning of a Maturity
          Date 
	 	If an Interest Period
        in respect of a Loan borrowed would otherwise overrun a Maturity Date
        or a Facility A Repayment Date applicable to that Loan, it shall be shortened
        so that it ends on the Maturity Date or the Facility A Repayment Date
        (as applicable).  
	 
	16.3  	Other adjustments 
	 	16.3.1  	If an Interest Period is not a period of a
        number of Months and it would otherwise end on a day which is not a Business
        Day, that Interest Period will instead end on the next Business Day in
        that calendar month (if there is one) of the preceding Business Day (if
        there is not).  
	 
	 	16.3.2  	The Facility Agent (after prior consultation
        with the Lenders) and the Company may enter into such other arrangements
        as they may agree for the adjustment of Interest Periods.  
	 
	16.4  	Notification 
	 	The Facility Agent shall
        notify the relevant Borrower and the Lenders of the duration of each
        Interest Period promptly after ascertaining its duration.  
	 
	17.  	CHANGES TO THE CALCULATION
          OF INTEREST 
	 
	17.1  	Absence of quotations 
	 	Subject to Clause 17.2
        (Market disruption),
        if LIBOR is to be determined by reference to the Reference Banks but
        a Reference Bank does not supply a quotation by the Specified Time on
        the Quotation Day, the applicable LIBOR shall be determined on the basis
        of the quotations of the remaining Reference Banks.  
	 
	17.2  	Market disruption 
	 	17.2.1  	If a Market Disruption Event occurs in relation
        to a Loan (not being a Swingline Loan) for any Interest Period, then
        the rate of interest on each Lender's share of that Loan for the Interest
        Period shall be the rate per annum which is the sum of:  

 - 42 -

	 	 	(a)  	 the Margin;  
	 
	 	 	(b)  	 the rate notified to the Facility
    Agent by that Lender as soon as practicable and in any event before interest
        is due to be paid in respect of that Interest Period, to be that which
        expresses as a percentage rate per annum the cost to that Lender of funding
        its participation in that Loan from whatever source it may reasonably
    select; and  
	 
	 	 	(c)  	the Mandatory Cost, if any, applicable to that
        Lender's participation in the Loan.  
	 
	 	17.2.2  	In this Agreement "Market
          Disruption Event" means:  
	 
	 	 	(a)  	at or about noon on the Quotation Day for the
        relevant Interest Period the Screen Rate is not available and none or
        only one of the Reference Banks supplies a rate to the Facility Agent
        to determine LIBOR for the relevant currency and Interest Period; or  
	 
	 	 	(b)  	before close of business in London on the Quotation
        Day for the relevant Interest Period, the Facility Agent receives notifications
        from a Lender or Lenders (whose participations in a Loan exceed 50 per
        cent. of that Loan) that the cost to it of obtaining matching deposits
        in the Relevant Interbank Market would be in excess of LIBOR.  
	 
	17.3  	Alternative basis of
          interest or funding 
	 	17.3.1  	If a Market Disruption
        Event occurs and the Facility Agent or the Company so requires, the Facility
        Agent and the Company shall enter into negotiations (for a period of
        not more than thirty days) with a view to agreeing a substitute basis
        for determining the rate of interest.  
	 
	 	17.3.2  	Any alternative basis
        agreed pursuant to sub-clause 17.3.1 above shall, with the prior consent
        of all the Lenders and the Company, be binding on all Parties.  
	 
	17.4  	Break Costs 
	 	17.4.1  	Each Borrower shall, within
        five Business Days of demand by a Finance Party, pay to that Finance
        Party its Break Costs attributable to all or any part of a Loan or Unpaid
        Sum being paid by that Borrower on a day other than the last day of an
        Interest Period for that Loan or Unpaid Sum.  
	 
	 	17.4.2  	Each Lender shall, as
        soon as reasonably practicable after a demand by the Facility Agent,
        provide a certificate confirming the amount of its Break Costs for any
        Interest Period in which they accrue.  
	 
	18.  	FEES 
	 
	18.1  	Commitment fee 
	 	18.1.1  	The Company shall pay
        to the Facility Agent (for the account of each Lender) a fee in the Base
        Currency computed at the rate of:  

 - 43 -

	 	 	(a)  	35 per cent. per annum of the applicable Margin
        on that Lender's Available Commitment under the Revolving Facility for
        the Availability Period applicable to the Revolving Facility; and  
	 
	 	 	(b)  	20 per cent. per annum of the applicable Margin
        on that Lender's Available Commitment under the Term Facilities for the
        Availability Period applicable to each Term Facility.  
	 
	 	18.1.2  	The accrued commitment fee is payable
        quarterly in arrear on the last day of each successive period of three
        Months, which ends during the relevant Availability Period, on the last
        day of the Availability Period and, if cancelled in full, on the cancelled
        amount of the relevant Lender's Commitment at the time the cancellation
    is effective.  

	 	 
	18.2  	Front end fee 
	 	The Company shall pay to the Arrangers a front
        end fee in the amount and at the times agreed in a Fee Letter.  
	 
	18.3  	Agency fee 
	 	The Company shall pay to the Facility Agent
        (for its own account) an agency fee in the amount and at the times agreed
        in a Fee Letter.  
	 
	18.4  	Extension Fee 
	 	The Company shall pay to the Facility Agent
        (for the account of each Lender) an extension fee of 0.10 per cent. of
        the amount of Facility B which is extended in accordance with Clause
        14 (Extension of Facility B) following
        the delivery of an Extension Notice. Such fee shall be paid on the date
        that Facility B is extended.  

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 SECTION 6

    ADDITIONAL PAYMENT OBLIGATIONS

	19.  	TAX GROSS UP AND INDEMNITIES 
	 
	19.1  	Definitions 
	 	19.1.1  	In this Agreement:  
	 
	 	 	"Protected
          Party" means a Finance Party which
          is or will be subject to any liability, or required to make any payment,
          for or on account of Tax in relation to a sum received or receivable
          (or any sum deemed for the purposes of Tax to be received or receivable)
          under a Finance Document.  
	 
	 	 	"Qualifying
          Lender" means:  
	 
	 	 	(a)  	with respect to a payment
        made by an Obligor incorporated in the United Kingdom,  
	 
	 	 	 	(i)  	a Lender which is beneficially
        entitled to interest payable to that Lender in respect of an advance
        under a Finance Document and is a Lender:  
	 
	 	 	 	 	(1)  	which is a bank (as defined for the purpose
        of section 349 of the Taxes Act) making an advance under a Finance Document;
        or  
	 
	 	 	 	 	(2)  	in respect of an advance made under a Finance
        Document by a person that was a bank (as defined for the purpose of section
        349 of the Taxes Act) at the time that that advance was made,  
	 	 	 	 	 	 
	 	 	 	and which is within the charge
        to United Kingdom corporation tax as respects any payments of interest
    made in respect of that advance; or  
	 	 	 	 	 	 
	 	 	 	(ii)  	a Treaty Lender
    with respect to the United Kingdom; or  

	 	 	(b)  	with respect to a payment
        made by a U.S. Obligor, a Lender which is:  
	 
	 	 	 	(i)  	a "United States person" within the meaning
        of Section 7701(a)(30) of the Code, provided such Lender has timely delivered
        to the Facility Agent for transmission to the Obligor making such payment
        two original copies of IRS Form W-9 (or any successor form) either directly
        or under cover of IRS Form W-8IMY (or any successor form) certifying
        its status as "United States person"; or  
	 
	 	 	 	(ii)  	a Treaty Lender with respect to the United
        States of America, provided such Lender has timely delivered to the Facility
        Agent for transmission to the Obligor making such payment two original
        copies of IRS Form W-8BEN (or any successor form) either directly or
        under cover of IRS Form W-8IMY (or any
        successor form) certifying its entitlement to receive such payments without
        any such deduction or withholdings under a double taxation treaty; or  

 - 45 -

	 	 	 	(iii)  	entitled to receive payments under the Finance
        Documents without deduction or withholding of any United States federal
        Tax either as a result of such payments being effectively connected with
        the conduct by such Lender of a trade or business within the United States
        or under the portfolio interest exemption, provided such Lender has timely
        delivered to the Facility Agent for transmission to the Obligor making
        such payment two original copies of either (1) IRS Form W-8ECI (or any
        successor form) either directly or under cover of IRS Form W-8IMY (or
        any successor form) certifying that the payments made pursuant to the
        Finance Documents are effectively connected with the conduct by that
        Lender of a trade or business within the United States or (2) IRS Form
        W-8BEN (or any successor form) either directly or under cover of IRS  Form
        W-8IMY (or any successor form) claiming exemption from withholding in
        respect of payments made pursuant to the Finance Documents under the
        portfolio interest exemption and a statement certifying that such Lender
        is not a person described in Section 871(h)(3)(B) or Section 881(c)(3)
        of the Code or (3) such other applicable form prescribed by the IRS certifying
        as to such Lender's entitlement to exemption from United States withholding
        tax with respect to all payments to be made to such Lender under the
        Finance Documents.  
	 
	 	 	 	For the purposes of this paragraph
        (b) above, in the case of a Lender that is not treated as the beneficial
        owner of the payment (or a portion thereof) under Chapter 3 and related
        provisions (including Sections 871, 881, 3406, 6401, 6405 and 6409) of
        the Code, the term "Lender" shall mean the person who is so treated as
    the beneficial owner of the payment (or portion thereof).  
	 	 	 	 	 
	 	 	"Tax
            Credit" means a credit against,
            relief or remission from, or repayment of any Tax.

       "Tax
            Deduction" means a deduction
            or withholding for or on account of Tax from a payment under a Finance
            Document.

       "Tax
            Payment" means either the increase
            in a payment made by an Obligor to a Finance Party under Clause 19.2
            (Tax gross-up)
            or a payment under Clause 19.3 (Tax
            indemnity).

       "Treaty
            Lender" with respect to a jurisdiction
            means a Lender which is, on the date any relevant payment falls due,
            entitled under the provisions of a double taxation treaty (a "Treaty")
            in force on that date to receive payments of interest from a person
            resident in such jurisdiction without a Tax Deduction (subject to
            the completion of any necessary procedural formalities, such as application
            by a Lender to HM Revenue & Customs that payments may be made
    to that Lender without a Tax Deduction). 

- 46 -

	 	19.1.2  	Unless a contrary indication
        appears, in this Clause 19 a reference to "determines" or "determined" means
        a determination made in the absolute discretion of the person making
        the determination.  
	 
	19.2  	Tax gross-up 
	 	19.2.1  	Each Obligor shall make
        all payments to be made by it without any Tax Deduction, unless a Tax
        Deduction is required by law.  
	 
	 	19.2.2  	The Company shall promptly
        upon becoming aware that an Obligor is required by law to make a Tax
        Deduction (or that there is any change in the rate or the basis of a
        Tax Deduction) notify the Facility Agent accordingly.  
	 
	 	19.2.3  	Each Lender as at the
        date of this Agreement confirms that it is a Qualifying Lender. This
        confirmation is given as at the date of this Agreement. A Lender which
        becomes party to this Agreement by means of a Transfer Certificate shall
        confirm therein whether it is or is not a Qualifying Lender. Each Lender
        which confirmed that it was a Qualifying Lender undertakes to notify
        the Facility Agent and the Company promptly upon becoming aware of it
        ceasing to be a Qualifying Lender (other than as a result of any change
        after it became a Lender under this Agreement, in (or in the interpretation,
        administration or application of) any law or Treaty, or any published
        practice or concession of any relevant Tax authority). If the Facility
        Agent receives such notification from a Lender it shall notify the Company
        and the relevant Obligor.  
	 
	 	19.2.4  	If a Tax Deduction is
        required by law to be made by an Obligor, the amount of the payment due
        from that Obligor shall be increased to an amount which (after making
        any Tax Deduction) leaves an amount equal to the payment which would
        have been due if no Tax Deduction had been required.  
	 
	 	19.2.5  	An Obligor is not required
        to make an increased payment to a Lender under sub- clause 19.2.4 above
        for a Tax Deduction in respect of Tax imposed by the United Kingdom or
        the United States from a payment of interest on a Loan, if on the date
        on which the payment falls due:  
	 
	 	 	(a)  	 the payment could have been made to the relevant
        Lender without a Tax Deduction if it was a Qualifying Lender (other
        than a Treaty Lender), but on that date that Lender is not or has ceased
        to be a Qualifying Lender other than as a result of any change after
        the date it became a Lender under this Agreement in (or in the interpretation,
        administration, or application of) any law or Treaty, or any published
        practice or concession of any relevant Tax authority; or  
	 
	 	 	(b)  	 the relevant Lender is a Treaty Lender and
        the Obligor making the payment is able to demonstrate that the payment
        could have been made to the Lender without the Tax Deduction had that
        Lender complied with its obligations, if any, under sub-clause 19.2.8
        below.  

 - 47 -

	 	19.2.6  	If an Obligor is required
        by law to make a Tax Deduction, that Obligor shall make that Tax Deduction
        and any payment required in connection with that Tax Deduction within
        the time allowed and in the minimum amount required by law.  
	 
	 	19.2.7  	Within thirty days of
        making either a Tax Deduction or any payment to the relevant Tax authority
        required in connection with that Tax Deduction, the Obligor making that
        Tax Deduction shall deliver to the Facility Agent for the Finance Party
        entitled to the payment evidence reasonably satisfactory to that Finance
        Party that the Tax Deduction has been made or (as applicable) any appropriate
        payment paid to the relevant authority.  
	 
	 	19.2.8  	A Treaty Lender and each
        Obligor which makes a payment to which that Treaty Lender is entitled
        shall co-operate in completing as soon as reasonably practicable any
        procedural formalities necessary for that Obligor to obtain authorisation
        to make that payment without a Tax Deduction.  
	 
	19.3  	Tax indemnity 
	 	19.3.1  	The Company shall (within
        three Business Days of demand by the Facility Agent) pay to a Protected
        Party an amount equal to the loss, liability or cost which that Protected
        Party determines will be or has been (directly or indirectly) suffered
        for or on account of Tax by that Protected Party in respect of a Finance
        Document or the transactions occurring under such Finance Document.  
	 
	 	19.3.2  	Sub-clause 19.3.1 above
        shall not apply:  
	 
	 	 	(a)  	with respect to any Tax
        assessed on a Finance Party:  
	 
	 	 	 	(i)  	under the law of the jurisdiction in which
        that Finance Party is incorporated or, if different, the jurisdiction
        (or jurisdictions) in which that Finance Party is treated as resident
        for Tax purposes; or  
	 
	 	 	 	(ii)  	under the law of the jurisdiction in which
        that Finance Party's Facility Office is located in respect of amounts
        received or receivable in that jurisdiction,  
	 
	 	 	 	if in either such case that Tax is imposed
        on or calculated by reference to the net income, profit or gains received
        or receivable (but not any sum deemed to be received or receivable) by
    that Finance Party or Facility Office; or  
	 
	 	 	(b)  	to the extent a loss,
        liability or cost:  
	 
	 	 	 	(i)  	is compensated for by an increased payment
        under Clause 19.2 (Tax gross-up);  
	 
	 	 	 	(ii)  	would have been compensated for by an increased
        payment under Clause 19.2 (Tax gross-up)
        but was not so compensated for solely because either or both of the exclusions
        in sub-clause 19.2.5 of Clause 19.2 (Tax
        gross- up) applied; or  

 - 48 -

	 	 	 	(iii)  	relates to any Tax assessed prior to the date
        which is 365 days prior to the date on which the Protected Party requests
        such payment from the Company, unless a determination of the amount claimed
    could only be made only on or after the earlier of those dates.  
	 
	 	19.3.3  	A Protected Party making,
        or intending to make, a claim under sub-clause 19.3.1 above shall promptly
        notify the Facility Agent of the loss, liability or cost which will give,
        or has given, rise to the claim, following which the Facility Agent shall
        reasonably promptly notify the Company.  
	 
	 	19.3.4  	A Protected Party shall,
        on receiving a payment from an Obligor under this Clause 19.3, notify
        the Facility Agent.  
	 
	19.4  	Tax Credit 
	 	If an Obligor makes a
        Tax Payment and the relevant Finance Party determines that:  
	 
	 	19.4.1  	a Tax Credit is attributable
        either to an increased payment of which that Tax Payment forms part,
        or to that Tax Payment; and  
	 
	 	19.4.2  	that Finance Party has
        obtained, utilised and retained that Tax Credit in whole or in part,  
	 
	 	the Finance Party shall
        pay an amount to the Obligor which that Finance Party determines (acting
        reasonably) will leave it (after that payment) in the same after-Tax
        position as it would have been in had the Tax Payment not been required
        to be made by the Obligor.  
	 
	19.5  	Stamp taxes 
	 	The Company shall pay
        and, within five Business Days of demand, indemnify each Finance Party
        against any cost, loss or liability that Finance Party incurs in relation
        to, all stamp duty, registration, excise and other similar Taxes payable
        in respect of any Finance Document or the transaction occurring under
        any of them other than in respect of an assignment or transfer by a Lender.  
	 
	19.6  	VAT 
	 	19.6.1  	All consideration expressed
        to be payable under a Finance Document by any Party to a Finance Party
        shall be deemed to be exclusive of any amounts in respect of VAT. If
        VAT is chargeable on any supply made by any Finance Party to any Party
        in connection with a Finance Document, that Party shall pay to the Finance
        Party (in addition to and at the same time as paying the consideration)
        an amount equal to the amount of the VAT against delivery of an appropriate
        VAT invoice.  
	 
	 	19.6.2  	If VAT is chargeable on
        any supply made by any Finance Party (the "Supplier")
        to any other Finance Party (the "Recipient") under a Finance
        Document, and any Party (the "Relevant
        Party") is required by the terms
        of any Finance Document to pay an amount equal to the consideration for
        such supply to the Supplier (rather than being required to reimburse
        the Recipient in respect of that consideration), such Party shall also
        pay to the Supplier (in addition to and at the same time as paying such
        amount) an amount equal to the amount of such VAT. The Recipient will  

 - 49 -

	 	 	promptly pay to the Relevant Party
        an amount equal to any credit or repayment from the relevant Tax authority
        which it reasonably determines relates to the VAT chargeable on that
    supply.  
	 
	 	19.6.3  	Where a Finance Document
        requires any Party to reimburse a Finance Party for any costs or expenses,
        that obligation shall be deemed to extend to all amounts in respect of
        VAT incurred by the Finance Party in respect of the costs or expenses
        to the extent that the Finance Party reasonably determines that neither
        the Finance Party nor any other member of any group of which it is a
        member for VAT purposes is entitled to credit or repayment of the amount
        in respect of the VAT.  
	 
	19.7  	Survival of obligations 
	 	Without prejudice to the
        survival of any other section of this Agreement, the agreements and obligations
        of each Obligor and each Finance Party contained in this Clause 19 shall
        survive the payment in full by the Obligors of all obligations under
        this Agreement and the termination of this Agreement.  
	 
	20.  	INCREASED COSTS 
	 
	20.1  	Increased costs 
	 	20.1.1  	Subject to Clause 20.3
        (Exceptions)
        the Company shall, within five Business Days of a demand by the Facility
        Agent, pay for the account of a Finance Party the amount of any Increased
        Costs incurred by that Finance Party or any of its Affiliates as a result
        of (i) the introduction of or any change in (or in the judicial or generally
        accepted interpretation or the administration or application of) any
        law or regulation or (ii) compliance with any law or regulation made
        after the date of this Agreement.  
	 
	 	20.1.2  	In this Agreement "Increased
          Costs" means:  
	 
	 	 	(a)  	a reduction in the rate of return from the
        Facility or on a Finance Party's (or its Affiliate's) overall capital;  
	 
	 	 	(b)  	an additional or increased cost; or  
	 
	 	 	(c)  	a reduction of any amount due and payable under
        any Finance Document,  
	 
	 	 	which is incurred or suffered
        by a Finance Party or any of its Affiliates to the extent that it is
        attributable to that Finance Party having entered into its Commitment
        or funding or performing its obligations under any Finance Document.  
	 
	20.2  	Increased cost claims 
	 	20.2.1  	A Finance Party intending
        to make a claim pursuant to Clause 20.1 (Increased
        costs) shall notify the Facility
        Agent of the event giving rise to the claim, following which the Facility
        Agent shall promptly notify the Company.  
	 
	 	20.2.2  	Each Finance Party shall,
        as soon as practicable after a demand by the Facility Agent, provide
        a certificate confirming the amount of its Increased Costs.  

 - 50 -

	20.3	Exceptions 
	 	20.3.1	Clause 20.1 (Increased
          costs) does not apply to the extent
          any Increased Cost is: 
	 
	 	 	(a)	attributable to a Tax Deduction required by
        law to be made by an Obligor; 
	 
	 	 	(b)	compensated for by Clause 19.3 (Tax
          indemnity), Clause 19.5 (Stamp
          taxes) or Clause 19.6 (VAT)
          (or would have been compensated for under those clauses but was not
          so compensated for because any of the exclusions, exceptions or carve-outs
          to such clauses applied); 
	 
	 	 	(c)	incurred prior to the date which is 365 days
        prior to the date on which the Finance Party makes a claim in accordance
        with Clause 20.2 (Increased cost
        claims), unless a determination of the amount incurred could only be made
        on or after the earlier of those dates; 
	 
	 	 	(d)	compensated for by the payment of the Mandatory
        Cost; 
	 
	 	 	(e)	attributable to the wilful breach by the relevant
        Finance Party or its Affiliates of any law or regulation; or 
	 
	 	 	(f)	attributable to the application of or compliance
        with the International Convergence of Capital Measurement Standards published
        by the Basel Committee on Banking Supervision in June 2004 ("Basel II"), or any implementation
        or transposition thereof, as such implementation or transposition is
        generally envisaged to take place as at the date of this Agreement, whether
        by an EC Directive or the FSA Integrated Prudential Sourcebook or other
        law or regulation, including (without limitation) any Increased Cost
        attributable to Pillar 2 (The Supervisory Review Process) of Basel II.
        In the event that the implementation or transposition of Basel II substantially
        changes from the implementation and transposition as it is envisaged
        to take place as at the date of this Agreement, the Parties undertake
        to negotiate in good faith any changes to this Clause 20 (Increased Costs) which may
        be necessary to reflect any Increased Costs incurred by any Finance Parties
        or any of its Affiliates as a result of those changes. 
	 
	 	20.3.2	In this Clause 20.3, a
        reference to a "Tax Deduction" has
        the same meaning given to the term in Clause 19.1 (Definitions). 
	 
	21.	OTHER INDEMNITIES 
	 
	21.1	Currency indemnity 
	 	21.1.1	If any sum due from an
        Obligor under the Finance Documents (a "Sum"),
        or any order, judgment or award given or made in relation to a Sum, has
        to be converted from the currency (the "First
        Currency") in which that Sum is
        payable into another currency (the "Second
        Currency") for the purpose of: 
	 
	 	 	(a)	making or filing a claim or proof against that
        Obligor; 

 - 51 -

	 	 	(b)	obtaining or enforcing an order, judgment or
        award in relation to any litigation or arbitration proceedings, 
	 	 	 	 
	 	 	that Obligor shall as an independent obligation,
        within five Business Days of demand, indemnify each Finance Party to
        whom that Sum is due against any cost, loss or liability arising out
        of or as a result of the conversion including any discrepancy between
        (A) the rate of exchange used to convert that Sum from the First Currency
        into the Second Currency and (B) the rate or rates of exchange available
    to that person at the time of its receipt of that Sum.
	 	 	 
	 	21.1.2	Each Obligor waives
        any right it may have in any jurisdiction to pay any amount under the
        Finance Documents in a currency or currency unit other than that in which
    it is expressed to be payable.

	21.2	Other indemnities 
	 	The Company shall (or
        shall procure that an Obligor will), within five Business Days of demand,
        indemnify each Finance Party against any cost, loss or liability incurred
        by that Finance Party as a result of: 
	 
	 	21.2.1	the occurrence of any Event of Default; 
	 
	 	21.2.2	a failure by an Obligor to pay any amount due
        under a Finance Document on its due date, including without limitation,
        any cost, loss or liability arising as a result of Clause 34 (Sharing
        among the Finance Parties); 
	 
	 	21.2.3	funding, or making arrangements to fund, its
        participation in a Loan requested by a Borrower (or the Company on behalf
        of a Borrower) in a Utilisation Request but not made by reason of the
        operation of any one or more of the provisions of this Agreement (other
        than by reason of default or negligence by that Finance Party alone);
        or 
	 
	 	21.2.4	a Loan (or part of a Loan) not being prepaid
        in accordance with a notice of prepayment given by a Borrower or the
        Company. 
	 
	21.3	Indemnity to the Facility
          Agent 
	 	The Company shall within
        five days of demand indemnify the Facility Agent against any cost, loss
        or liability incurred by the Facility Agent (acting reasonably) as a
        result of: 
	 
	 	21.3.1	investigating any event which it reasonably
        believes is a Default; or 
	 
	 	21.3.2	entering into or performing any foreign exchange
        contract for the purposes of Clause 8.3 (Revocation
        of Currency); or 
	 
	 	21.3.3	acting or relying on any notice, request or
        instruction which it reasonably believes to be genuine, correct and appropriately
        authorised. 

 - 52 -

	22.	MITIGATION BY THE LENDERS 
	 
	22.1	Mitigation 
	 	22.1.1	Each Finance Party shall, in consultation with
        the Company, take all reasonable steps to mitigate any circumstances
        which arise and which would result in any amount becoming payable under
        or pursuant to, or cancelled pursuant to, any of Clause 11.1 (Illegality),
        Clause 19 (Tax gross-up and indemnities)
        or Clause 20 (Increased costs)
        including (but not limited to) transferring its rights and obligations
        under the Finance Documents to another Affiliate or Facility Office. 
	 
	 	22.1.2	Sub-clause 22.1.1 above does not in any way
        limit the obligations of any Obligor under the Finance Documents. 
	 
	 	22.1.3	Each Finance Party shall notify the Facility
        Agent as soon as reasonably practicable after it becomes aware that any
        circumstances of the kind described in sub-clause 22.1.1 above have arisen
        or may arise. The Facility Agent shall notify the Company promptly of
        any such notification from a Finance Party. 
	 
	22.2	Limitation of liability 
	 	22.2.1	The Company shall indemnify each Finance Party
        for all costs and expenses reasonably incurred by that Finance Party
        as a result of steps taken by it under Clause 22.1 (Mitigation). 
	 
	 	22.2.2	A Finance Party is not obliged to take any
        steps under Clause 22.1 (Mitigation)
        if, in the opinion of that Finance Party (acting reasonably), to do so
        might be prejudicial to it. 
	 
	23.	COSTS AND EXPENSES 
	 
	23.1	Transaction expenses 
	 	The Company shall promptly
        on demand pay each Agent and the Arranger reasonable professional fees
        and all out of pocket expenses (including legal fees subject to any cap
        referred to in a Fee Letter) properly incurred by any of them in connection
        with the negotiation, preparation, printing and execution of: 
	 
	 	23.1.1	this Agreement and any other documents referred
        to in this Agreement; and 
	 
	 	23.1.2	any other Finance Documents executed after
        the date of this Agreement. 
	 
	23.2	Amendment costs 
	 	If (a) an Obligor requests
        an amendment, waiver or consent or (b) an amendment is required pursuant
        to Clause 35.9 (Change of currency),
        the Company shall, within five Business Days of demand, reimburse each
        Agent for the amount of all costs and expenses (including legal fees)
        reasonably incurred by that Agent in responding to, evaluating, negotiating
        or complying with that request or requirement. 
	 
	23.3	Enforcement costs 
	 	The Company shall, within
        five Business Days of demand, pay to each Finance Party the amount of
        all: 

 - 53 -

	 	23.3.1	reasonable costs and expenses (including legal
        fees) incurred by that Finance Party in connection with the preservation;
        and 
	 
	 	23.3.2	costs and expenses (including legal fees) incurred
        by that Finance Party in connection with the enforcement, 
	 	 	 
	 	of any rights under, any Finance Document.

 

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 SECTION 7

    GUARANTEE

	24.	GUARANTEE AND INDEMNITY 
	 
	24.1	Guarantee and indemnity 
	 	Each Guarantor irrevocably
        and unconditionally jointly and severally: 
	 
	 	24.1.1	guarantees to each Finance Party punctual performance
        by each Borrower of all that Borrower's obligations under the Finance
        Documents; 
	 
	 	24.1.2	undertakes with each Finance Party that whenever
        a Borrower does not pay any amount when due under or in connection with
        any Finance Document, that Guarantor shall immediately on demand pay
        that amount as if it was the principal obligor; and 
	 
	 	24.1.3	indemnifies each Finance Party immediately
        on demand against any cost, loss or liability suffered by that Finance
        Party if any obligation guaranteed by it is or becomes unenforceable,
        invalid or illegal. The amount of the cost, loss or liability shall be
        equal to the amount which that Finance Party would otherwise have been
        entitled to recover. 
	 
	24.2	Continuing guarantee 
	 	This guarantee is a continuing
        guarantee and will extend to the ultimate balance of sums payable by
        any Obligor under the Finance Documents, regardless of any intermediate
        payment or discharge in whole or in part. 
	 
	24.3	Reinstatement 
	 	If any payment by an Obligor
        or any discharge given by a Finance Party (whether in respect of the
        obligations of any Obligor or any security for those obligations or otherwise)
        is avoided or reduced as a result of insolvency or any similar event: 
	 
	 	24.3.1	the liability of each Obligor shall continue
        as if the payment, discharge, avoidance or reduction had not occurred;
        and 
	 
	 	24.3.2	each Finance Party shall be entitled to recover
        the value or amount of that security or payment from each Obligor, as
        if the payment, discharge, avoidance or reduction had not occurred. 
	 
	24.4	Waiver of defences 
	 	The obligations of each
        Guarantor under this Clause 24 will not be affected by an act, omission,
        matter or thing which, but for this Clause, would reduce, release or
        prejudice any of its obligations under this Clause 24 (without limitation
        and whether or not known to it or any Finance Party) including: 
	 
	 	24.4.1	any time, waiver or consent granted to, or
        composition with, any Obligor or other person; 

 - 55 -

	 	24.4.2	the release of any other Obligor or any other
        person under the terms of any composition or arrangement with any creditor
        of any member of the Group; 
	 
	 	24.4.3	the taking, variation, compromise, exchange,
        renewal or release of, or refusal or neglect to perfect, take up or enforce,
        any rights against, or security over assets of, any Obligor or other
        person or any non-presentation or non-observance of any formality or
        other requirement in respect of any instrument or any failure to realise
        the full value of any security; 
	 
	 	24.4.4	any incapacity or lack of power, authority
        or legal personality of or dissolution or change in the members or status
        of an Obligor or any other person; 
	 
	 	24.4.5	any amendment (however fundamental) or replacement
        of a Finance Document or any other document or security; 
	 
	 	24.4.6	any unenforceability, illegality or invalidity
        of any obligation of any person under any Finance Document or any other
        document or security; or 
	 
	 	24.4.7	any insolvency or similar proceedings. 
	 
	24.5	Immediate recourse 
	 	Each Guarantor waives
        any right it may have of first requiring any Finance Party (or any trustee
        or agent on its behalf) to proceed against or enforce any other rights
        or security or claim payment from any person before claiming from that
        Guarantor under this Clause 24. This waiver applies irrespective of any
        law or any provision of a Finance Document to the contrary. 
	 
	24.6	Appropriations 
	 	Until all amounts which
        may be or become payable by the Obligors under or in connection with
        the Finance Documents have been irrevocably paid in full, each Finance
        Party (or any trustee or agent on its behalf) may: 
	 
	 	24.6.1	refrain from applying or enforcing any other
        moneys, security or rights held or received by that Finance Party (or
        any trustee or agent on its behalf) in respect of those amounts, or apply
        and enforce the same in such manner and order as it sees fit (whether
        against those amounts or otherwise) and no Guarantor shall be entitled
        to the benefit of the same; and 
	 
	 	24.6.2	hold in an interest-bearing suspense account
        any moneys received from any Guarantor or on account of any Guarantor's
        liability under this Clause 24. 
	 
	24.7	Deferral of Guarantors'
          rights 
	 	Until all amounts which
        may be or become payable by the Obligors under or in connection with
        the Finance Documents have been irrevocably paid in full and unless the
        Facility Agent otherwise directs, no Guarantor will exercise any rights
        which it may have by reason of performance by it of its obligations under
        the Finance Documents: 
	 
	 	24.7.1	to be indemnified by an Obligor; 

 - 56 -

	 	24.7.2	to claim any contribution from any other guarantor
        of any Obligor's obligations under the Finance Documents; and/or 
	 
	 	24.7.3	to take the benefit (in whole or in part and
        whether by way of subrogation or otherwise) of any rights of the Finance
        Parties under the Finance Documents or of any other guarantee or security
        taken pursuant to, or in connection with, the Finance Documents by any
        Finance Party. 
	 
	24.8	Release of Guarantor's
          right of contribution 
	 	If any Guarantor (a "Retiring
          Guarantor") ceases to be a Guarantor
          in accordance with the terms of the Finance Documents for the purpose
          of any sale or other disposal of that Retiring Guarantor then on the
          date such Retiring Guarantor ceases to be a Guarantor: 
	 
	 	24.8.1	that Retiring Guarantor is released by each
        other Guarantor from any liability (whether past, present or future and
        whether actual or contingent) to make a contribution to any other Guarantor
        arising by reason of the performance by any other Guarantor of its obligations
        under the Finance Documents; and 
	 
	 	24.8.2	each other Guarantor waives any rights it may
        have by reason of the performance of its obligations under the Finance
        Documents to take the benefit (in whole or in part and whether by way
        of subrogation or otherwise) of any rights of the Finance Parties under
        any Finance Document or of any other security taken pursuant to, or in
        connection with, any Finance Document where such rights or security are
        granted by or in relation to the assets of the Retiring Guarantor. 
	 
	24.9	Additional security 
	 	This guarantee is in addition
        to and is not in any way prejudiced by any other guarantee or security
        now or subsequently held by any Finance Party. 
	 
	24.10	Limitation on U.S.
          Guarantors 
	 	Any term or provision
        of this Clause 24 or any other term in this Agreement or any Finance
        Document notwithstanding, the maximum aggregate amount of the obligations
        for which any U.S. Guarantor shall be liable under this Agreement shall
        in no event exceed an amount equal to the largest amount that would not
        render such U.S. Guarantor's obligations under this Agreement subject
        to avoidance under applicable United States federal or state fraudulent
        conveyance laws. 

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 SECTION 8

 REPRESENTATIONS, UNDERTAKINGS
      AND EVENTS OF DEFAULT

	25.	REPRESENTATIONS 
	 
	25.1	Time of Representations 
	 	25.1.1	Subject to sub-clause 25.1.2, each Obligor
        makes the representations and warranties set out in this Clause 25 to
        each Finance Party on the date of this Agreement. 
	 
	 	25.1.2	The representation given at Clause 25.11.3
        of Clause 25.11 (No misleading information)
        below is made on the Information Memorandum Date and on the Syndication
        Date only, provided that, in relation to the representation to be given
        on the Syndication Date, such representation shall be qualified by any
        matters disclosed by the Company in writing to the Facility Agent in
        the period from the day after the Information Memorandum Date to the
        day before the Syndication Date. 
	 
	25.2	Status 
	 	25.2.1	It is a corporation, duly incorporated and
        validly existing under the law of its jurisdiction of incorporation. 
	 
	 	25.2.2	It and each of its Subsidiaries has the power
        to own its assets and carry on its business as it is being conducted. 
	 
	25.3	Binding obligations 
	 	The obligations expressed
        to be assumed by it in each Finance Document are, subject to laws or
        legal procedures affecting the enforceability of creditors' rights generally
        and any other reservations set out in the legal opinions listed in Schedule
        2 (Conditions precedent),
        legal, valid, binding and enforceable obligations. 
	 
	25.4	Non-conflict with other
          obligations 
	 	The entry into and performance
        by it of, and the transactions contemplated by, the Finance Documents
        do not and will not conflict with: 
	 
	 	25.4.1	any law or regulation applicable to it; 
	 
	 	25.4.2	its or any of its Subsidiaries' constitutional
        documents; or 
	 
	 	25.4.3	any agreement or instrument binding upon it
        or any of its Subsidiaries or any of its or any of its Subsidiaries'
        assets which conflict would reasonably be likely to have a Material Adverse
        Effect. 
	 
	25.5	Power and authority 
	 	It has the power to enter
        into, perform and deliver, and has taken all necessary action to authorise
        its entry into, performance and delivery of, the Finance Documents to
        which it is a party and the transactions contemplated for it by those
        Finance Documents. 
	 
	25.6	Validity and admissibility
          in evidence 
	 	All Authorisations required: 

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	 	25.6.1	to enable it lawfully to enter into, exercise
        its rights and comply with its obligations in the Finance Documents to
        which it is a party; and 
	 
	 	25.6.2	to make the Finance Documents to which it is
        a party admissible in evidence in its jurisdiction of incorporation, 
	 
	 	(other than as disclosed
        in a legal opinion delivered to the Facility Agent pursuant to Part I
        of Schedule 2 (Conditions precedent))
        have been obtained or effected and are in full force and effect. 
	 
	25.7	Governing law and enforcement 
	 	25.7.1	The choice of English law as the governing
        law of the Finance Documents will be recognised and enforced in its jurisdiction
        of incorporation. 
	 
	 	25.7.2	Any judgment obtained in England in relation
        to a Finance Document will be recognised and enforced in its jurisdiction
        of incorporation. 
	 
	25.8	Deduction of Tax 
	 	It is not required to
        make any deduction for or on account of Tax from any payment it may make
        under any Finance Document to a Qualifying Lender falling within sub-clause
        19.1.1(a)(i) of Clause 19.1 (Definitions). 
	 
	25.9	No filing or stamp
          taxes 
	 	Under the law of its jurisdiction
        of incorporation it is not necessary that the Finance Documents be filed,
        recorded or enrolled with any court or other authority in that jurisdiction
        or that any stamp, registration or similar Tax be paid in such jurisdiction
        on or in relation to the Finance Documents or the transactions contemplated
        by the Finance Documents. 
	 
	25.10	No default 
	 	No Event of Default is
        continuing or might reasonably be expected to result from the making
        of any Utilisation. 
	 
	25.11	No misleading information 
	 	25.11.1 	Any factual information, including any information
        which discloses evidence of material litigation which is pending or threatened,
        provided by any member of the Group to any of the Finance Parties prior
        to the date of this Agreement in connection with its entry into this
        Agreement was true and accurate in all material respects as at the date
        it was provided or as at the date (if any) at which it is stated. 
	 
	 	25.11.2 	No information has been given or withheld that
        results in the information referred to in sub-clause 25.11.1 above being
        untrue or misleading in any material respect. 
	 
	 	25.11.3 	Any factual information relating to the Group
        or New River contained in the Information Memorandum was true and accurate
        and complete in all material respects as at the date of the Information
        Memorandum or (as the case may be) as at the date the information is
        expressed to be given and nothing has occurred or been omitted which
        would result in the information being inaccurate or misleading in any
        material respect. 

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	 	25.11.4  	The copy of the Acquisition Agreement provided
        to the Agent by the Company pursuant to Schedule 2 (Conditions
        precedent) is true, accurate, and
        complete.  
	 
	 	25.11.5  	As of the date of this Agreement, there has
        been no change in the business or the consolidated financial condition
        of the Group since the date of its last audited financial statements
        that would have a Material Adverse Effect.  
	 
	25.12  	Financial statements 
	 
	 	In the case of the Company
        only:  
	 
	 	25.12.1  	Its Original Financial Statements were prepared
        in accordance with U.S. GAAP consistently applied.  
	 
	 	25.12.2  	Its Original Financial Statements fairly represent
        its financial condition and operations (consolidated) during the relevant
        financial year.  
	 
	25.13  	Pari passu ranking 
	 
	 	Its payment obligations
        under the Finance Documents rank at least pari
        passu with the claims of all its
        other unsecured and unsubordinated creditors, except for obligations
        mandatorily preferred by law applying to companies generally.  
	 
	25.14  	ERISA and Multiemployer
          Plans 
	 
	 	25.14.1  	Each Employee Plan is in compliance in form
        and operation with ERISA and the Code and all other applicable laws and
        regulations save where any failure to comply would not reasonably be
        expected to have a Material Adverse Effect.  
	 
	 	25.14.2  	Each Employee Plan which is intended to be
        qualified under Section 401(a) of the Code has been determined by the
        IRS to be so qualified or is in the process of being submitted to the
        IRS for approval or will be so submitted during the applicable remedial
        amendment period, and, nothing has occurred since the date of such determination
        that would reasonably be expected to adversely affect such determination
        (or, in the case of an Employee Plan with no determination, nothing has
        occurred that would materially adversely affect such qualification) except,
        in each case, to the extent the same would not reasonably be expected
        to have a Material Adverse Effect.  
	 
	 	25.14.3  	There exists no Unfunded Pension Liability
        with respect to any Employee Plan, except as would not have a Material
        Adverse Effect.  
	 
	 	25.14.4  	Neither the U.S. Obligor nor any ERISA Affiliate
        has incurred a complete or partial withdrawal from any Multiemployer
        Plan, and if each of the U.S. Obligors and each ERISA Affiliate were
        to withdraw in a complete withdrawal as of the date hereof, the aggregate
        withdrawal liability that would be incurred would not reasonably be expected
        to have a Material Adverse Effect.  
	 
	 	25.14.5  	There are no actions, suits or claims pending
        against or involving an Employee Plan (other than routine claims for
        benefits) or, to the knowledge of the Company, any U.S. Obligor or any
        ERISA Affiliate, threatened, which would reasonably be expected to be
        asserted successfully against any Employee Plan and, if so asserted  

 - 60 -

	 	 	successfully, would reasonably be
        expected either singly or in the aggregate to have a Material Adverse
    Effect.  
	 
	 	25.14.6  	Each U.S. Obligor and any ERISA Affiliate has
        made all material contributions to or under each such Employee Plan required
        by law within the applicable time limits prescribed thereby, the terms
        of such Employee Plan, or any contract or agreement requiring contributions
        to an Employee Plan save where any failure to comply would not reasonably
        be expected to have a Material Adverse Effect.  
	 
	 	25.14.7  	Neither any U.S. Obligor nor any ERISA Affiliate
        has ceased operations at a facility so as to become subject to the provisions
        of Section 4068(a) of ERISA, withdrawn as a substantial employer so as
        to become subject to the provisions of Section 4063 of ERISA or ceased
        making contributions to any Employee Plan subject to Section 4064(a)
        of ERISA to which it made contributions except, in each case, to the
        extent the same would not reasonably be expected to have a Material Adverse
        Effect.  
	 
	 	25.14.8  	Neither any U.S. Obligor nor any ERISA Affiliate
        has incurred or reasonably expects to incur any liability to PBGC save
        for any liability for premiums due in the ordinary course or other liability
        which would not reasonably be expected to have a Material Adverse Effect.  
	 
	25.15  	Federal Reserve Regulations 
	 	None of the proceeds of
        the Loans or other extensions of credit under this Agreement will be
        used, directly or indirectly, in violation of Regulation U or Regulation
        X.  
	 
	25.16  	Investment Companies 
	 	No Obligor or Subsidiary
        of an Obligor is required to be registered as an "investment company" under
        the U.S. Investment Company Act of 1940 (the "1940
        Act").  
	 
	25.17  	Repetition 
	 	The Repeating Representations
        are deemed to be made by each Obligor (by reference to the facts and
        circumstances then existing) on:  
	 
	 	25.17.1  	the date of each Utilisation Request and the
        first day of each Interest Period; and  
	 
	 	25.17.2  	in the case of an Additional Obligor, the day
        on which the company becomes (or it is proposed that the company becomes)
        an Additional Obligor.  
	 
	26.  	INFORMATION UNDERTAKINGS 
	 
	 	The undertakings in this
        Clause 26 remain in force from the date of this Agreement for so long
        as any amount is outstanding under the Finance Documents or any Commitment
        is in force.  
	 
	26.1  	Financial statements 
	 	The Company shall supply
        to the Facility Agent in sufficient copies for all the Lenders:  

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	 	26.1.1  	as soon as the same are made public, but in
        any event within 120 days after the end of each of its financial years
        its audited consolidated financial statements for that financial year;
        and  
	 
	 	26.1.2  	as soon as the same are made public, but in
        any event within 90 days after the end of each half of each of its financial
        years its unaudited consolidated financial statements for that financial
        half year.  
	 
	26.2  	Compliance Certificate 
	 	26.2.1  	The Company shall supply to the Facility Agent,
        with each set of financial statements delivered pursuant to sub-clauses
        26.1.1 and 26.1.2 of Clause 26.1 (Financial
        statements), a Compliance Certificate
        setting out (in reasonable detail) computations as to compliance with
        Clause 27 (Financial covenants)
        as at the date as at which those financial statements were drawn up.
        The first such Compliance Certificate shall be delivered for the financial
        year ending 31 December 2007.  
	 
	 	26.2.2  	Each Compliance Certificate shall be signed
        by two directors (one of which is the finance director) of the Company.  
	 
	26.3  	Requirements as to
          financial statements 
	 	26.3.1  	The Company shall procure that each set of
        financial statements delivered pursuant to Clause 26.1 (Financial
        statements) is prepared using U.S.
        GAAP.  
	 
	 	26.3.2  	The Company shall procure that each set of
        financial statements delivered pursuant to Clause 26.1 (Financial
        statements) is prepared using U.S.
        GAAP, and accounting practices and financial reference periods consistent
        with those applied in the preparation of the Original Financial Statements
        unless, in relation to any set of financial statements, it notifies the
        Facility Agent that there has been a change in U.S. GAAP, or the accounting
        practices or reference periods and its auditors deliver to the Facility
        Agent:  

	 	 	 	 	 
	 	 	 	(i)  	a description of any change necessary for those
        financial statements to reflect the U.S. GAAP, accounting practices and
        reference periods upon which those Original Financial Statements were
        prepared; and  
	 
	 	 	 	(ii)  	sufficient information, in form and substance
        as may be reasonably required by the Facility Agent, to enable the Lenders
        to determine whether Clause 27 (Financial
        Covenants) has been complied with
        and make an accurate comparison between the financial position indicated
        in those financial statements and those Original Financial Statements.  

	 	 	Any reference in this Agreement to those financial
        statements shall be construed as a reference to those financial statements
        as adjusted to reflect the basis upon which the Original Financial Statements
    were prepared.  
	 	 	 
	 	26.3.3  	If the Company notifies the Facility Agent
        of a change in accordance with sub- clause 26.3.2 above then the Company
        and Facility Agent shall enter into negotiations in good faith with a
        view to agreeing:  

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	 	 	 	(i)  	whether or not the change might result in any
        material alteration in the commercial effect of any of the terms of this
        Agreement; and  
	 
	 	 	 	(ii)  	if so, any amendments to this Agreement which
        may be necessary to ensure that the change does not result in any material
        alteration in the commercial effect of those terms,  
	 	 	 	 	 
	 	 	and if any amendments are agreed they shall
        take effect and be binding on each of the Parties in accordance with
    their terms.  

	26.4  	Information: miscellaneous 
	 	The Company shall supply
        to the Facility Agent (in sufficient copies for all the Lenders, if the
        Facility Agent so requests):  
	 
	 	26.4.1  	all documents dispatched
        by the Company to its shareholders (or any class of them) or its creditors
        generally at the same time as they are dispatched;  
	 
	 	26.4.2  	copies of any public announcement
        made by the Company which discloses the details of any material litigation,
        arbitration or administrative proceedings which are current, threatened
        or pending against any member of the Group; and  
	 
	 	26.4.3  	promptly, such further
        information as any Finance Party (through the Facility Agent) may reasonably
        request at reasonable times and at reasonable intervals.  
	 
	26.5  	Notification of default 
	 	Each Obligor shall notify
        the Facility Agent of any Default (and the steps, if any, being taken
        to remedy it) promptly upon becoming aware of its occurrence (unless
        that Obligor is aware that a notification has already been provided by
        another Obligor).  
	 
	26.6  	"Know your customer" checks 
	 	26.6.1  	If:  
	 
	 	 	(a)  	the introduction of or any change in (or in
        the interpretation, administration or application of) any law or regulation
        made after the date of this Agreement;  
	 
	 	 	(b)  	any change in the status of an Obligor or the
        composition of the shareholders of an Obligor after the date of this
        Agreement; or  
	 
	 	 	(c)  	a proposed assignment or transfer by a Lender
        of any of its rights and obligations under this Agreement to a party
        that is not a Lender (which would be permitted under Clause 30 (Changes
        to the Lenders)) prior to such assignment
        or transfer,  
	 
	 	 	obliges an Agent or any Lender (or, in the
        case of paragraph (c) above, any prospective new Lender) to comply with "know
        your customer" or similar identification procedures in circumstances
        where the necessary information is not already available to it, each
        Obligor shall promptly upon the request of any Agent or any Lender supply,
        or procure the supply of, such documentation and other evidence as is
    within that Obligor's possession or control reasonably requested by  

 - 63 -

	 	 	that Agent (for itself or on behalf
        of any Lender) or any Lender (for itself or, in the case of the event
        described in paragraph (c) above, on behalf of any prospective new Lender)
        in order for the Agent, such Lender or, in the case of the event described
        in paragraph (c) above, any prospective new Lender to carry out and be
        satisfied it has complied with all necessary "know your customer" or
        other similar checks under all applicable laws and regulations pursuant
    to the transactions contemplated in the Finance Documents.  
	 
	 	26.6.2  	Each
        Lender shall promptly upon the request of an Agent supply, or procure
        the supply of, such documentation and other evidence as is reasonably
        requested by the Agent (for itself) in order for the Agent to carry out
        and be satisfied it has complied with all necessary "know your customer" or
        other similar checks required under all applicable laws and regulations
    pursuant to the transactions contemplated in the Finance Documents.  
	 
	 	26.6.3   	The Company shall, by not less than 10 Business
        Days' prior written notice to the Agent, notify the Agent (which shall
        promptly notify the Lenders) of its intention to request that one of
        its Subsidiaries becomes an Additional Obligor pursuant to Clause 31
    (Changes to the Obligors).  
	 
	 	26.6.4   	Following the giving of any notice pursuant
        to sub-clause 26.6.3 above, if the accession of such Additional Obligor
        obliges an Agent or any Lender to comply with "know your customer"
      or similar identification procedures in circumstances where the necessary
      information is not already available to it, the Company shall promptly
      upon the request of that Agent or any Lender supply, or procure the supply
      of, such documentation and other evidence as is reasonably requested by
      the Agent (for itself or on behalf of any Lender) or any Lender (for itself
      or on behalf of any prospective new Lender) in order for the Agent or such
      Lender or any prospective new Lender to carry out and be satisfied it has
      complied with the results of all necessary "know your customer" or other
      similar checks under all applicable laws and regulations pursuant to the
    accession of such Subsidiary to this Agreement as an Additional Obligor.  
	 
	26.7  	"Know your customer" confirmation 
	 	Each Lender confirms as
        at the date of this Agreement that, under "know your customer" requirements
        in existence as at the date of this Agreement, it does not require financial
        statements for Obligors other than the Company.  
	 
	27.  	FINANCIAL COVENANTS 
	 
	27.1  	Financial definitions 
	 	In this Clause 27:  
	 
	 	"Borrowings" means,
        at any time, any indebtedness in respect of:  
	 
	 	(a)  	the principal amount of
        moneys borrowed and any net debit balances at banks after application
        of applicable account pooling arrangements;  

 - 64 -

	 	(b)  	the principal amount raised under acceptance
        credit facilities other than acceptances relating to the purchase or
        sale of goods in the ordinary course of trading;  
	 
	 	(c)  	the principal amount of any debenture, bond,
        note, loan stock, commercial paper or other securities;  
	 
	 	(d)  	the capitalised element of indebtedness under
        finance leases or capital leases entered into primarily as a method of
        raising finance or financing the acquisition of the asset leased;  
	 
	 	(e)  	receivables sold or discounted other than receivables
        sold or discounted in the ordinary course of trading or on non-recourse
        terms;  
	 
	 	(f)  	indebtedness arising from deferred payment
        agreements except in the ordinary course of trading;  
	 
	 	(g)  	any fixed or minimum premium payable on repayment
        of any debt instrument;  
	 
	 	(h)  	principal amounts raised under any other transaction
        having the commercial effect of a borrowing; or  
	 
	 	(i)  	(without double counting) any guarantee, indemnity
        or similar assurance for any of the items referred to in paragraphs (a)
        to (h) above.  
	 	 	 
	 	"Cash" means,
    at any time:  

	 	(a)  	cash at bank denominated in sterling, dollars,
        euro or other currency freely convertible into the Base Currency and
        freely transferable and credited to an account in the name of a member
        of the Group with a reputable financial institution and to which a member
        of the Group is alone beneficially entitled and for so long as that cash
        is repayable on demand; (i) repayment of that cash is not contingent
        on the prior discharge of any other indebtedness of any Group member
        or of any other person whatsoever or on the satisfaction of any other
        condition; (ii) there is no Security over that cash except Security created
        or constituted pursuant to a Finance Document or Security securing obligations
        of a member of the Group granted in favour of another member of the Group;
        and (iii) such cash is freely and immediately available and convertible
        into the Base Currency to be applied in repayment or prepayment of the
        Borrowings; and  
	 
	 	(b)  	to the extent the relevant indebtedness is
        included in Borrowings, cash collateral provided for such indebtedness
        up to a maximum amount equal to the principal amount of such indebtedness.  
	 	 	 
	 	"Cash
    Equivalent Investments" means:  
	 	 	 
	 	(a)  	debt securities denominated in sterling, dollars,
        euro or other currency freely convertible into the Base Currency issued
        by, or unconditionally guaranteed by the United Kingdom or the United
    States of America or other which are not convertible  

- 65 -

	 	 	into any other form of security and having
        not more than three months to final maturity;  
	 
	 	(b)  	debt securities denominated in sterling, dollars
        or euro or other currency freely convertible into the Base Currency which
        are not convertible into any other form of security, and having not more
        than three months to final maturity, at all times rated P-1 (Moody's
        Investor Services Inc.) or A-1 (Standard & Poors' Corporation) and
        which are not issued or guaranteed by any member of the Group;  
	 
	 	(c)  	certificates of deposit denominated in sterling,
        dollars or euro or other currency freely convertible into the Base Currency
        issued by, and acceptances by, banking institutions authorised under
        applicable legislation of the United Kingdom rated P-1 (Moody's Investor
        Services Inc.) or A-1 (Standard & Poor's Corporation); and  
	 
	 	(d)  	other securities (if any) approved in writing
        by the Facility Agent,  
	 	 	 
	 	provided that:  

 

	 	(a)  	there is no Security over the investments referred
        to in paragraphs (a) to (d) above except Security created or constituted
        pursuant to a Finance Document or Security securing obligations of a
        member of the Group granted in favour of another member of the Group;
        and  
	 
	 	(b)  	cash proceeds of the investments referred to
        in paragraphs (a) to (d) above are freely and immediately available and
        convertible into the Base Currency to be applied in repayment or prepayment
        of the Borrowings.  
	 	 	 
	 	"EBITDA" means
        in respect of any Relevant Period, consolidated operating income for
    such period (after giving effect to the following adjustments, if applicable):  

	 	(a)  	before deducting any corporation
        tax or other taxes on income, profits or gains;  
	 
	 	(b)  	before deducting interest
        payable and before adding interest receivable;  
	 
	 	(c)  	before deducting unusual
        or non-recurring losses or charges, provided
        that:  
	 
	 	 	(i)  	to the extent such charges
        include a current or future period cash component, such amounts shall
        be deducted from EBITDA when paid, except for:  
	 
	 	 	 	(A)  	any fees and expenses relating to the Acquisition
        (and any other acquisition which occurs within 12 months from the date
        of this Agreement), including financial and investment banking fees,
        in an aggregate amount not in excess of US$50,000,000 paid prior
        to the Facility A Maturity Date;  
	 
	 	 	 	(B)  	integration and reorganisation costs or claims
        relating to the Acquisition or the acquisition of Transkaryotic (as defined
        in the 2005 Agreement) (and any other acquisition which occurs within
        12 months from the date of this Agreement), and US reorganisation costs,
        in an aggregate amount  

 - 66 -

	 	 	 	 	not in excess of US$100,000,000 paid prior
        to the Facility A Maturity Date;  
	 
	 	 	 	(C)  	NRP 104 Milestone Payments; and  
	 
	 	 	 	(D)  	other up-front milestone and licensing payments,
        not in excess of US$100,000,000 paid prior to the Facility A Maturity
        Date,  
	 	 	 	 	 
	 	 	 	provided that the
        aggregate amount of costs in relation to sub-paragraphs (A), (B) and
        (D) above must not exceed US$100,000,000 in any 12 month period;
    and  

	 	 	(ii)  	any accruals or reserves
        in the ordinary course of business shall be excluded;  

	 	 	 
	 	(d)  	before adding extraordinary gains and non-cash
        gains;  
	 
	 	(e)  	after deducting the amount of net profit (or
        adding back the amount of net loss) of any Group company (other than
        the Company) which is attributable to any third party (other than another
        Group company) which is a shareholder in that Group company;  
	 
	 	(f)  	after adding back the amount of any loss and
        after deducting the amount of any gain against book value arising on
        a disposal of any asset (other than stock disposed of in the ordinary
        course of trading);  
	 
	 	(g)  	before taking into account any unrealised exchange
        gains and losses;  
	 
	 	(h)  	after deducting any income (to the extent not
        received in cash) and adding back any loss from any associate or joint
        venture or any other companies in which a Group company has a minority
        interest;  
	 
	 	(i)  	before deducting any depreciation or amortisation;  
	 
	 	(j)  	before deducting any distributions; and  
	 
	 	(k)  	before deducting any non-cash write-offs of
        in-process research and development, goodwill, non-cash stock compensation
        charges, non-cash stock revaluation charges arising on an acquisition
        and non-cash write-offs of any investments, intellectual property or
        fixed assets.  
	 	 	 
	 	For the purposes
        of sub-clause 27.2.1 of Clause 27.2 (Financial
        condition) only, EBITDA shall be
        adjusted, at any time, on a pro-forma basis to include businesses or
        assets acquired in the period and exclude businesses or assets disposed
        of in the period (and for the avoidance of doubt, EBITDA in respect of
        the business of New River and its Subsidiaries shall be calculated by
        annualising the figures for any Relevant Period during which New River
    and its subsidiaries are owned by the Group).  
	 	 
	 	"Liquid
    Investments" means at any time:  

- 67 -

	 	(a)  	any investment in marketable
        debt obligations for which a recognised trading market exists and not
        convertible or exchangeable to any other security provided
        that:  
	 
	 	 	(i)  	each obligation has a credit rating of either
        A+ or A-1 or higher by Standard & Poor's Corporation (or in each
        case the equivalent rating including the equivalent money market fund
        rating by Standard & Poor's Corporation) or A1 or P-1 or higher by
        Moody's Investor Services Inc. (or in each case the equivalent rating
        including the equivalent money market fund rating by Moody's Investor
        Services Inc.) and further provided that no more than
        25 per cent. of all such investments shall be rated A+ and A-1 by Standard & Poor's
        Corporation (and in each case the equivalent rating including the equivalent
        money market fund rating by Standard & Poor's Corporation) and A1
        and P-1 by Moody's Investor Services Inc. (and in each case the equivalent
        rating including the equivalent money market fund rating by Moody's Investor
        Services Inc.);  
	 
	 	 	(ii)  	each obligation is beneficially owned by a
        member of the Group;  
	 
	 	 	(iii)  	no obligation is issued by or guaranteed by
        a member of the Group; and  
	 
	 	 	(iv)  	there is no Security over such obligation save
        pursuant to the Finance Documents or Security securing obligations of
        a member of the Group granted in favour of another member of the Group;
        and  
	 
	 	(b)  	any investment accessible
        within 30 days in money market funds which have a credit rating of either
        A-1 or higher by Standard & Poor's Corporation (or in each case the
        equivalent rating including the equivalent money market fund rating by
        Standard & Poor's Corporation) or P-1 or higher by Moody's Investor
        Services Inc.  
	 
	 	 	(or in each case the equivalent
        rating including the equivalent money market fund rating by Moody's Investor
        Services Inc.) or Rule 2a7 Money Market Funds as defined in the US Investment
        Company Act 1940 provided that:  
	 
	 	 	(i)  	such investment is beneficially owned by a
        member of the Group; and  
	 
	 	 	(ii)  	there is no Security over such investment save
        pursuant to the Finance Documents or Security securing obligations of
        a member of the Group granted in favour of another member of the Group,  
	 	 	 	 
	 	provided that the
          cash proceeds of the investments referred to in paragraphs (a) and
          (b) above, either through sale or redemption, are freely and immediately
          available and convertible into the Base Currency to be applied in repayment
          or prepayment of the Borrowings.

       "Net
            Debt" means, at any time, the
            aggregate consolidated Borrowings of the Group from sources external
            to the Group, less all Cash and Cash Equivalent Investments of the
    Group and the then mark to market value of Liquid Investments.

- 68 -

	 	"Net
          Interest" means, in respect of
          any Relevant Period, the sum of (a) the amount of interest and similar
          charges payable in respect of Borrowings by the Group during such period
          less (b) the amount of interest received or receivable and any similar
          income of the Group during such period excluding any payment or amortisation
          of arrangement fees payable under or in connection with this Agreement
          or any Fee Letter.  
	 
	 	"Relevant
          Period" means each period of twelve
          months ending on the last day of the Company's financial year and each
          period of twelve months ending on the last day of the first half of
          the Company's financial year with the first such period ending on 31
          December 2007.  
	 
	27.2  	Financial condition 
	 	The Company shall ensure
        that:  
	 
	 	27.2.1  	the ratio of Net Debt
        to EBITDA of the Group in respect of the most recently ended Relevant
        Period shall not, at any time, exceed:  
	 
	 	 	(a)  	3.50:1 for the 12 month period ending 31 December
        2007;  
	 
	 	 	(b)  	3.25:1 for the 12 month period ending 30 June
        2008; and  
	 
	 	 	(c)  	3.00:1 for each 12 month period ending 31 December
        and 30 June thereafter; and  
	 
	 	27.2.2  	the ratio of EBITDA of
        the Group to Net Interest in respect of the most recently ended Relevant
        Period shall not be less than 4.0:1.  
	 
	27.3  	Financial testing 
	 	27.3.1  	The financial covenants
        set out in Clause 27.2 (Financial
        condition) shall be tested by reference
        to each of the financial statements and/or each Compliance Certificate
        delivered pursuant to Clause 26.2 (Compliance
        Certificate) with the first such
        test to be made in respect of the Relevant Period ending on 31 December
        2007.  
	 
	 	27.3.2  	If sub-clause 26.3.3 of
        Clause 26.3 (Requirements as to financial
        statements) applies (and for so
        long as no amendments to the contrary have been agreed pursuant to sub-clause
        26.3.3 of Clause 26.3 (Requirements
        as to financial statements)), then
        the financial covenants set out in Clause 27.2 (Financial condition) shall
        be tested by reference to the relevant financial statements as adjusted
        pursuant to sub-clause 26.3.3 of Clause 26.3 (Requirements
        as to financial statements) (and/or
        relevant Compliance Certificate delivered in accordance with Clause 26.2
        (Compliance Certificate))
        to reflect the basis upon which the Original Financial Statements were
        prepared, and to the extent relevant, any other information delivered
        to the Facility Agent in accordance with sub-clause 26.3.3 of Clause
        26.3 (Requirements as to financial statements).  

 - 69 -

	
28.	
GENERAL UNDERTAKINGS    
	 
	 	
The undertakings in this Clause 28 remain in force from the date of this Agreement for so long as any amount is outstanding under the Finance Documents or any Commitment is in force. 
	 
	
28.1	
Authorisations  
	 	
Each Obligor shall promptly obtain, comply with and do all that is necessary to maintain in full force and effect any Authorisation required under any law or regulation of its jurisdiction of incorporation to enable it to
perform its obligations under the Finance Documents and to ensure the legality, validity, enforceability or admissibility in evidence in its jurisdiction of incorporation of any Finance Document subject to any applicable bankruptcy, insolvency,
reorganisation, moratorium and other similar laws or legal procedures affecting the enforceability of creditors' rights generally and any other reservations set out in any of the legal opinions listed in Schedule 2 (Conditions precedent). 
	 
	
28.2	
Compliance with laws    
	 	
Each Obligor shall comply in all respects with all laws to which it may be subject, if failure so to comply would have a Material Adverse Effect.      
	 
	
28.3	
Negative pledge 

	 	
28.3.1	
No Obligor shall (and the Company shall ensure that no other member of the Group will) create or permit to subsist any Security over any of its assets.        
	 
	 	
28.3.2	
No Obligor shall (and the Company shall ensure that no other member of the Group will):        
	 
	 	 	
(a)	
sell, transfer or otherwise dispose of any of its assets on terms whereby they are or may be leased to or re-acquired by an Obligor or any other member of the Group;  
	 
	 	 	
(b)	
sell, transfer or otherwise dispose of any of its receivables on recourse terms;       
	 
	 	 	
(c)	
enter into any arrangement under which money or the benefit of a bank or other account may be applied, set-off or made subject to a combination of accounts; or        
	 
	 	 	
(d)	
enter into any other preferential arrangement having a similar effect, 
	 
	 	 	
in circumstances where the arrangement or transaction is entered into primarily as a method of raising Financial Indebtedness or of financing the acquisition of an asset.     
	 
	 	
28.3.3	
Sub-clauses 28.3.1 and 28.3.2 above do not apply to:   
	 
	 	 	
(a)	
any Security (or transaction ("Quasi-Security") described in sub-clause 28.3.2 above) created with the prior written consent of the Majority
Lenders; 
	 
	 	 	
(b)	
any Security or Quasi-Security listed in Schedule 9 (Existing Security) except to the extent the principal amount secured by that Security exceeds the
amount stated in that Schedule;  

- 70 -

	 	
(c)	
any netting or set-off arrangement entered into by any member of the Group in the ordinary course of its banking arrangements for the purpose of netting or setting-off debit and credit balances;     
	 
	 	
(d)	
any lien arising by operation of law and in the ordinary course of trading and not as a result of any default or omission by any member of the Group;  
	 
	 	
(e)	
any future title retention provisions to which a member of the Group is subject entered into in the ordinary course of trading;        
	 
	 	
(f)	
any netting or set-off arrangement entered into by any member of the Group under any treasury transaction entered into in the ordinary course of business;     
	 
	 	
(g)	
any Security or Quasi-Security over or affecting any asset acquired by a member of the Group after the date of this Agreement if:      

	 	 	
(i)	
the Security or Quasi-Security was not created in contemplation of the acquisition of that asset by a member of the Group;     
	 	 	 	 
	 	 	
(ii)	
the principal amount secured has not been increased in contemplation of, or since the acquisition of that asset by a member of the Group; and  
	 	 	 	 
	 	 	
(iii)	
the Security or Quasi-Security is removed or discharged within six months of the date of acquisition of such asset;    
	 	 	 	 
	 	
(h)	
any Security or Quasi-Security over or affecting any asset of any company which becomes a member of the Group after the date of this Agreement, where the Security or Quasi-Security is created prior to the date on which that
company becomes a member of the Group, if:       
	 	 	 	 
	 	 	
(i)	
the Security or Quasi-Security was not created in contemplation of the acquisition of that company;    
	 	 	 	 
	 	 	
(ii)	
the principal amount secured has not increased in contemplation of or since the acquisition of that company; and       
	 	 	 	 
	 	 	
(iii)	
the Security or Quasi-Security is removed or discharged within six months of that company becoming a member of the Group;      
	 	 	 	 
	 	
(i)	
any Security entered into pursuant to any Finance Document;    
	 	 	 	 
	 	
(j)	
any Security or Quasi-Security created in connection with a Permitted Securitisation; or       
	 	 	 	 
	 	
(k)	
any Security or Quasi-Security securing indebtedness the principal amount of which (when aggregated with the principal amount of any other indebtedness which has the benefit of Security or Quasi-Security given by any member
of the Group other than any permitted under paragraphs (a) to (h) above) does not exceed at any time US$200,000,000 (or its equivalent in another currency or currencies).   

- 71 -

	 	
28.3.4	
Sub-clause 28.3.2 above does not apply to any Quasi-Security granted by a member of the Group or to any Security granted by a member of the Group in favour of another wholly owned member of the Group but only in respect of
liabilities owing to the Group.  
	 	 	 	 
	
28.4	
Disposals       
	 	
28.4.1	
No Obligor shall (and the Company shall ensure that no other member of the Group will), enter into a single transaction or a series of transactions (whether related or not) and whether voluntary or involuntary to sell,
lease, transfer, dispose by way of de-merger or otherwise dispose of any asset.  
	 	 	 	 
	 	
28.4.2	
Sub-clause 28.4.1 above does not apply to any sale, lease, transfer or other disposal: 
	 	 	 	 
	 	 	
(a)	
made in the ordinary course of business of the disposing entity;       
	 	 	 	 
	 	 	
(b)	
of assets in exchange for other assets which are comparable or superior as to value;   
	 	 	 	 
	 	 	
(c)	
in the form of out-licensing arrangements entered into by a member of the Group in the ordinary course of trading;     
	 	 	 	 
	 	 	
(d)	
of obsolete assets on normal commercial terms; 
	 	 	 	 
	 	 	
(e)	
of assets by one member of the Group to another member of the Group;   
	 	 	 	 
	 	 	
(f)	
of cash for any purpose permitted under the Finance Documents; 
	 	 	 	 
	 	 	
(g)	
of assets held by any member of the Group if such member of the Group has already contracted to dispose of such assets at the time such member of the Group is acquired;       
	 	 	 	 
	 	 	
(h)	
made with the prior written consent of the Majority Lenders;   
	 	 	 	 
	 	 	
(i)	
of cash by the payment of dividends and other distributions in respect of share capital which are not contrary to law; 
	 	 	 	 
	 	 	
(j)	
made in connection with a Permitted Securitisation; or 
	 	 	 	 
	 	 	
(k)	
at market value and on arm's length terms where (i) the higher of the market value and consideration receivable (when aggregated with the higher of the market value and consideration receivable for any other sale, lease,
transfer or other disposal by the Group, other than any permitted under paragraphs (a) to (j) above) does not exceed US$500,000,000 (or its equivalent in another currency or currencies) in any financial year or an aggregate of
US$1,500,000,000 until the date which is the Facility A Maturity Date or, to the extent that it does exceed such capped amounts, the Disposal Proceeds (which, for the purposes of these excess amounts only, shall not take into account any
Excluded Disposal Proceeds) are applied in mandatory prepayment of the Facilities in accordance with the provisions of sub-clause        

- 72 -

	 	 	 	
12.2.1 to 12.2.4 of Clause 12.2 (Mandatory Prepayment and Cancellation out of certain proceeds); or (ii) the sale, lease, transfer or other disposal
is of assets of New River (other than NRP 104) or of other assets acquired after the date of this Agreement),    
	 
	 	 	
  provided that no sale, lease, transfer or other disposal which would otherwise be permitted pursuant to the terms of paragraphs (a) to (k) (inclusive) above which would be deemed to be a class 1 transaction under the
Listing Rules of the Financial Services Authority shall be permitted without the consent of the Majority Lenders.        
	 
	 	
For the purpose of this Clause 28.4, "ordinary course of business" means the ordinary course of trading of the relevant entity or made as part of the
day-to-day operation of the relevant entity as carried on at the date hereof or as part of any activities ancillary to the ordinary course of trading.   

	 	 	 
	 28.5	 Change of business 
	 	The Company shall procure that no substantial
        change is made to the general nature of the business of the Group from
    that carried on at the date of this Agreement.
	 	 	 
	 28.6	 Insurance 
	 	 Each Obligor shall (and the Company
        shall ensure that each member of the Group will) maintain material insurances
        on and in relation to its business and assets against those risks and
        to the extent as is usual for companies carrying on the same or substantially
        similar business (and each member of the Group may maintain insurances
    with a captive insurer for this purpose).
	 	 	 

	
28.7	
Loans and Guarantees    
	 	
28.7.1	
No Obligor shall (and the Company shall ensure that no member of the Group will) make any loans or grant any credit.   
	 
	 	
28.7.2	
Sub-clause 28.7.1 above does not apply to:     

	 	 	
(a)	
loans existing at the date of this Agreement and listed in Schedule 10 (Existing Loans) to the Agreement except to the extent the principal amount of
the loans exceeds the amount stated in that Schedule;    
	 
	 	 	
(b)	
trade credit in the ordinary course of trading;        
	 
	 	 	
(c)	
loans to directors or employees in the ordinary course of business not exceeding US$10,000,000 in aggregate;       
	 
	 	 	
(d)	
loans or credit made by one member of the Group to another member of the Group;        
	 
	 	 	
(e)	
loans entered into pursuant to any Finance Documents;  
	 
	 	 	
(f)	
loans or credit made with the consent of the Majority Lenders; and     
	 
	 	 	
(g)	
loans or credit the principal amount of which (when aggregated with the principal amount of any other loans given by any member of the Group other     

- 73 -

	 	 	
than any permitted under paragraphs (a) to (f) above) does not exceed US$100,000,000 (or its equivalent in another currency or currencies).        
	 
	
28.8	
Financial Indebtedness  
	 	
28.8.1	
No Obligor shall (and the Company shall ensure that no member of the Group will) incur or allow to remain outstanding any Financial Indebtedness.      
	 
	 	
28.8.2	
Sub-clause 28.8.1 above does not apply to:     
	 
	 	 	
(a)	
any Financial Indebtedness incurred under the Finance Documents;       
	 
	 	 	
(b)	
any Existing Financial Indebtedness and any refinancing thereof (to the extent the aggregate amount outstanding is not increased as a result of or pursuant to the refinancing);       
	 
	 	 	
(c)	
trade credit in the ordinary course of trading;        
	 
	 	 	
(d)	
Financial Indebtedness to the extent owed by one member of the Group to another member of the Group;   
	 
	 	 	
(e)	
any Financial Indebtedness not otherwise described in this sub-clause 28.8.2 to the extent it is (i) required to be applied in prepayment and cancellation of the Facilities pursuant to sub-clause 12.2.1 to 12.2.4 inclusive
of Clause 12.2 (Mandatory prepayment and Cancellation out of certain proceeds) or (ii) is applied in voluntary prepayment and cancellation of the Facilities pursuant to Clause
11 (Illegality, Voluntary Prepayment and Cancellation); 
	 
	 	 	
(f)	
a derivative transaction entered into in the ordinary course of treasury operations and not for speculative purposes;  
	 
	 	 	
(g)	
Financial Indebtedness incurred with the consent of the Majority Lenders;      
	 
	 	 	
(h)	
any Financial Indebtedness of New River or its Subsidiaries existing at the time of the Acquisition (and any refinancing thereof (to the extent that the aggregate amount outstanding is not increased as a result of or
pursuant to the refinancing)) if that Financial Indebtedness was not created in contemplation of the Acquisition and (other than in relation to the New River Convertible Bond), if that Financial Indebtedness is repaid within six months of the
Acquisition;     
	 
	 	 	
(i)	
any Permitted Securitisation;  
	 
	 	 	
(j)	
unsecured loan notes issued by any member of the Group (including unsecured loan notes guaranteed by the Company and issued by another member of the Group) pursuant to a loan note alternative to an offer which complies with
all of the following conditions: (i) the offer is an offer made by or on behalf of a member of the Group to acquire (inter alia) all the ordinary shares in a public company
which are not owned by the offeror or by any member of the Group, or a scheme of arrangement proposed by such a public company for a     

- 74 -

	 	 	 	corresponding purpose; (ii) the offer
        is for cash consideration or includes a cash alternative; and (iii) the
        offer is subject to and complies with the UK Takeover Code or any law
        or regulation which replaces itprovided
        that such loan notes will only fall
        within this sub-paragraph (j) to the extent that the aggregate principal
        amount outstanding of such loan notes at any time does not exceed an
        amount equal to the aggregate of the Available Commitments of all the
        Revolving Facility Lenders under the Revolving Facility at such time; 
	 	 	 	 
	 	 	(k)	until such time as (i) all amounts
        outstanding under or in respect of Facility A and Facility B have been
        repaid in full and (ii) to the extent that the Total Revolving Facility
        Commitments have been reduced to US$500,000,000 in accordance with
        subclause 12.2 (Mandatory prepayment
        and cancellation out of certain proceeds)
        other Financial Indebtedness, the principal amount of which (when aggregated
        with the principal amount of any other Financial Indebtedness incurred
        by any member of the Group other than any permitted under paragraphs
        (a) to (j) above) does not, at any time, exceed US$200,000,000 (or
        its equivalent in another currency or currencies); and 
	 	 	 	 
	 	 	(l)	following (i) the repayment in full
        of all amounts outstanding under Facility A and Facility B and (ii) the
        reduction of the Total Revolving Facility Commitments to US$500,000,000
        (in accordance with subclause 12.2 (Mandatory
        prepayment and cancellation out of certain proceeds),
        subclause 11.2 (Voluntary Cancellation) or subclause 11.3 (Voluntary
        Prepayment of Loans)) other Financial
        Indebtedness, the principal amount of which (when aggregated with the
        principal amount of any other Financial Indebtedness incurred by any
        member of the Group other than any permitted under paragraphs (a) to
        (j) above) does not, at any time, exceed US$500,000,000 (or its equivalent
        in another currency or currencies). 
	 	 	 	 
	28.9	Compliance with ERISA
	 	No Obligor shall:
	 	 

	 	28.9.1	allow, or permit any of its ERISA
        Affiliates to allow, (i) any Employee Plan with respect to which any
        Obligor or any of its ERISA Affiliates may have any liability to be voluntarily
        terminated, (ii) any Obligor or ERISA Affiliates to withdraw from any
        Employee Plan, (iii) any ERISA Event to occur with respect to any Employee
        Plan, or (iv) any unwaived Accumulated Funding Deficiency (as defined
        in Section 302 of ERISA and Section 412 of the Code) to exist involving
        any of its Employee Plans; to the extent that any of the events described
        in (i), (ii), (iii) or (iv), singly or in the aggregate, could have a
        Material Adverse Effect; 
	 	 	 
	 	28.9.2	allow, or permit any of its ERISA
        Affiliates to allow the aggregate amount of any Unfunded Pension Liabilities
        among all Employee Plans (taking into account only Employee Plans with
        Unfunded Pension Liabilities existing at the time) at any time to exceed
        an amount which would be reasonably likely to have a Material Adverse
        Effect; 

 - 75 -

	 	28.9.3	fail, or permit any of its ERISA
        Affiliates to fail, to comply in any material respect with ERISA or the
        related provisions of the Code, if any such non-compliance, singly or
        in the aggregate, would be reasonably likely to have a Material Adverse
        Effect; or 
	 
	 	28.9.4	establish or become part of a Multiemployer
        Plan. 
	 	 	 

	28.10	Conduct of the Acquisition 
	 	28.10.1 	The Company shall ensure that no
        material amendments (including, without limitation, any amendments to,
        or waivers of, any of the conditions to the Offer (as defined in the
        Acquisition Agreement)) are made to the Acquisition Documents without
        the prior consent of the Arrangers, unless such changes are required
        by applicable law or regulations. 
	 	 	 
	 	28.10.2 	The Company shall comply with all
        material obligations under the terms of the Acquisition Documents. 

	29.	EVENTS OF DEFAULT
	 	 
	 	Each of the events or circumstances
        set out in this Clause 29 is an Event of Default (subject to, in the
        case of an Events of Default relating to the Acquisition of New River
        and its Subsidiaries, the remedy period referred to in Clause 29.14 (Clean
        up period)).
	 	 
	29.1	Non-payment
	 	An Obligor does not pay on the due
        date any amount payable pursuant to a Finance Document at the place at
        and in the currency in which it is expressed to be payable unless: 
	 	 	 
	 	29.1.1	its failure to pay is caused by administrative
        or technical error; and 
	 	 	 
	 	29.1.2	payment is made within five Business
        Days of its due date. 
	 	 	 

	29.2	Financial covenants 
	 	Any requirement of Clause
        27 (Financial covenants)
        is not satisfied. 
	 
	29.3	Other obligations 
	 	29.3.1	An Obligor does not comply with
        any provision of the Finance Documents (other than those referred to
        in Clause 29.1 (Non-payment)
        and Clause 29.2 (Financial covenants)). 
	 
	 	29.3.2	No Event of Default under sub-clause
        29.3.1 above will occur if the failure to comply is capable of remedy
        and is remedied within 20 Business Days of the Facility Agent giving
        notice to the Company or the Company becoming aware of the failure to
        comply. 
	 	 	 

	29.4	Misrepresentation 
	 	Any representation or statement made
        or deemed to be made by an Obligor in the Finance Documents is or proves
        to have been incorrect or misleading in any material respect when made
        or deemed to be made and which, if the circumstances giving rise to the
        misrepresentation or the misrepresentation are capable of remedy, are
        not remedied within 

 - 76 -

	 	20 Business Days of the Facility
        Agent giving notice to the Company or the Company becoming
        aware of the misrepresentation.
	 	 
	29.5	Cross default 
	 	29.5.1	Any Financial Indebtedness of any
        member of the Group is not paid when due nor within any originally applicable
        grace period. 
	 
	 	29.5.2	Any Financial Indebtedness of any
        member of the Group is declared to be or otherwise becomes due and payable
        prior to its specified maturity as a result of an event of default (however
        described). 
	 
	 	29.5.3	Any commitment for any Financial
        Indebtedness of any member of the Group is cancelled or suspended by
        a creditor of any member of the Group as a result of an event of default
        (however described). 
	 
	 	29.5.4	Any creditor of any member of the
        Group becomes entitled to declare any Financial Indebtedness of any member
        of the Group due and payable prior to its specified maturity as a result
        of an event of default (however described). 
	 
	 	29.5.5	No Event of Default will occur under
        this Clause 29.5 if the aggregate amount of Financial Indebtedness or
        commitment for Financial Indebtedness falling within sub- clauses 29.5.1
        to 29.5.4 above is less than US$50,000,000 (or its equivalent in
        any other currency or currencies). 
	 
	29.6	Insolvency 
	 	29.6.1	A Material Company is unable or admits
        inability to pay its debts as they fall due, suspends making payments
        on any of its debts or, by reason of actual or anticipated financial
        difficulties, commences negotiations with one or more of its creditors
        with a view to rescheduling any of its indebtedness. 
	 
	 	29.6.2	The value of the assets of any Material
        Company is less than its liabilities (taking into account contingent
        and prospective liabilities). 
	 	 	 
	 	29.6.3	A moratorium is declared in respect
        of any indebtedness of any Material Company. 
	 	 	 
	29.7	Insolvency proceedings 
	 	29.7.1	Any corporate action, legal proceedings
        or other procedure or step is taken in relation to: 
	 	 	 

	 	 	(a)	the suspension of payments, a moratorium
        of any indebtedness, winding-up, dissolution, administration or reorganisation
        (by way of voluntary arrangement, scheme of arrangement or otherwise)
        of any Material Company other than a solvent liquidation or reorganisation
        of any Material Company which is not an Obligor; 
	 
	 	 	(b)	a composition, compromise, assignment
        or arrangement with any creditor of any Material Company; 

 - 77 -

	 	 	(c) 	the appointment of a
        liquidator (other than in respect of a solvent liquidation of a Material
        Company which is not an Obligor), receiver, administrative receiver,
        administrator, compulsory manager or other similar officer in respect
        of any Material Company or any of its assets; or
	 	 	 	 
	 	 	(d)	enforcement of any Security
        over any assets of any Material Company,
	 	 	 	 
	 	 	or any analogous procedure
        or step is taken in any jurisdiction. 
	 	 	 	 
	 	29.7.2	Notwithstanding paragraphs
        (a) to (d) above, an Event of Default will occur under this Clause 29.7
        only if in the case of a petition being presented or an application made
        for the appointment of a liquidator or administrator, it is not discharged
        within 21 days. 
	 	 	 	 
	29.8	Creditors' process
	 	Any expropriation, attachment,
        sequestration, distress or execution affects any asset or assets of a
        Material Company which has an aggregate value of not less than US$10,000,000.
	 	 	 	 
	29.9	Ownership of the Obligors
	 	An Obligor (other than a Company)
        is not or ceases to be a Subsidiary of the Company.
	 	 	 	 
	29.10	Unlawfulness
	 	It is or becomes unlawful for an
        Obligor to perform any of its obligations under the Finance Documents.
	 	 
	29.11	Repudiation
	 	An Obligor repudiates a Finance
        Document or evidences an intention to repudiate a Finance Document.
	 	 
	29.12	Material adverse change
	 	29.12.1	A material adverse change in the
        business, operations, assets or financial condition of the Group, considered
        as a whole, which is likely to have a material adverse effect on the
        ability of the Obligors, taken as a whole, or the Company to meet their
        respective payment obligations under this Agreement.
	 	 	 	 
	 	29.12.2	For the purpose of
        a determination in respect of sub-clause 29.12.1 above, the following
        events and information will be considered not to have a material adverse
        effect described under sub-clause 29.12.1 above:
	 	 	 	 
	 	 	(a)	any litigation, arbitration, administrative
        or regulatory proceedings disclosed in the 10-Q and 10-K statements of
        the Company or New River most recently filed with the SEC prior to the
        date of this Agreement; or
	 	 	 	 
	 	 	(b)	completion of the Acquisition,
	 	 	 	 
	 	 	and for the avoidance of doubt,
        a product coming off patent or orphan designation in the normal course
        of its life cycle (including the financial effects thereof) shall not
    constitute a material adverse change under this Clause 29.12.

 - 78 -

	29.13	Employee Plans 
	 	Any ERISA Event shall
        have occurred or Clause 28.9 (Compliance
        with ERISA) shall be breached, and
        the liability of a U.S. Obligor or its ERISA Affiliates, either individually
        or in the aggregate, related to such ERISA Event or breaches, individually
        or when aggregated with all other ERISA Events and all such breaches,
        would have or would be reasonably expected to have a Material Adverse
        Effect. 
	 	 
	29.14	Clean up period 

	 	29.14.1	For a period of 4 Months from (and
        including) the date on which a member of the Group becomes the owner
        of record of the shares or other assets the subject of the Acquisition,
        an event which would otherwise constitute a Default or an Event of Default
        but for this Clause 29.14 (Clean
        up period) will not constitute an
        Event of Default, provided that: 
	 	 	 

	 	 	(a)	it is an event which is capable
        of remedy; and 
	 
	 	 	(b)	that event relates to New River
        and/or its Subsidiaries. 
	 	 	 	 
	 	29.14.2	For a period of 3 months from (and
        including) the date on which a member of the Group becomes the owner
        of record of the shares or other assets which are the subject of a subsequent
        acquisition, an event which would otherwise constitute a Default or an
        Event of Default but for this Clause 29.14 (Clean
        up period) will not constitute an
    Event of Default, provided that: 
	 	 	 	 
	 	 	(a)	it is an event which is capable of remedy;
    and
	 	 	 	 
	 	 	(b)	that event relates to the target
        company or target undertaking of that further acquisition, or the Subsidiaries
    of such target company or target undertaking.
	 	 	 	 
	29.15	Acceleration
	 	On and at any time after
        the occurrence of an Event of Default which is continuing but subject
        to the terms of Clause 4.7 (Utilisations
        during the Certain Funds Period) the Facility Agent may, and shall if so directed by the
    Majority Lenders, by notice to the Company:
	 	 	 
	 	29.15.1	cancel the Total Commitments
    whereupon they shall immediately be cancelled;
	 	 	 
	 	29.15.2	declare that all or
        part of the Loans, together with accrued interest, and all other amounts
        accrued or outstanding under the Finance Documents be immediately due
        and payable, whereupon they shall become immediately due and payable;
    and/or
	 	 	 
	 	29.15.3	declare that all or
        part of the Loans be payable on demand, whereupon they shall immediately
        become payable on demand by the Facility Agent on the instructions of
    the Majority Lenders.
	 	 	 
	 	If an Event of Default
        under Clause 29.7 (Insolvency Proceedings)
        shall occur in respect of any U.S. Obligor as a result of the filing
        by or against such U.S. Obligor of a petition for relief under the United
        States Bankruptcy Code, then without notice to such U.S. Obligor or any
        other act by the Facility Agent or any other person, the Loans to such
        U.S. Obligor, interest thereon and all other amounts owed by such U.S.
    Obligor under the Finance 

 

 - 79 -

	 	Documents shall become immediately
        due and payable without presentment, demand, protest or notice of any
    kind, all of which are expressly waived. 

 

 - 80 -

 SECTION 9

    CHANGES TO PARTIES

	30.	CHANGES TO THE LENDERS 
	 
	30.1	Assignments and transfers
          by the Lenders 
	 	Subject to this Clause
        30, a Lender (the "Existing Lender")
        may: 

  

	 	30.1.1	assign any of its rights; or 
	 
	 	30.1.2	transfer by novation any of its
        rights and obligations, 
	 
	 	to another bank or financial institution
        (the "New Lender") provided
    that:
	 
	 	30.1.3	any Revolving Lender which transfers
        all or any part of its Revolving Commitment shall in addition transfer
        or procure its Affiliate to transfer, as the case may be, a pro
        rata proportion of its or its Affiliate's
        Swingline Commitment (if any); and 
	 
	 	30.1.4	any Swingline Lender which transfers
        all or any part of its Available Swingline Commitment shall in addition
        transfer or procure its Affiliate to transfer, as the case may be, a pro
        rata portion of its or its Affiliate's
        Revolving Commitment (if any). 

 

	30.2	Conditions of assignment or transfer
	 	30.2.1	A transfer of part of a Commitment
        or the rights and obligations under this Agreement by the Existing Lender
        must be in a minimum amount of US$10,000,000. 
	 
	 	30.2.2	Subject to subclause 30.2.1 above,
        an Existing Lender may transfer a part of each of its Facility A Commitments,
        Facility B Commitments and Revolving Facility Commitments separately,
        and is not required to pro rate the amounts transferred across each Facility. 
	 
	 	30.2.3	The consent of the Company is required
        for an assignment or transfer by an Existing Lender, unless: 

	 	 	 	 
	 	 	(a)	the assignment or transfer is to
        another Lender or an Affiliate of a Lender; or 
	 
	 	 	(b)	at the time of the assignment or
        transfer, an Event of Default has occurred and is continuing. 
	 

	 	30.2.4	The consent of the Company to an
        assignment or transfer must not be unreasonably withheld or delayed.
        The Company will be deemed to have given its consent ten Business Days
        after the Existing Lender has requested it unless consent is expressly
    refused by the Company within that time.
	 	 	 	 
	 	30.2.5	An assignment will be effective
    only on:
	 	 	 	 
	 	 	(a)	receipt by the Facility Agent of
        written confirmation from the New Lender (in form and substance satisfactory
        to the Facility Agent) that the New Lender 

 - 81 -

	 	 	 	will assume the same obligations
        to the other Finance Parties as it would have been under if it was an
    Original Lender;
	 
	 	 	(b)	performance by the relevant Agent
        of all "know your customer" or other checks relating to any person that
        it is required to carry out in relation to such assignment to a New Lender,
        the completion of which that Agent shall promptly notify to the Existing
        Lender and the New Lender; and 
	 
	 	 	(c)	entry by the New Lender into a Confidentiality
        Undertaking with the Company. 
	 	 	 	 
	 	30.2.6	A transfer will only be effective if the procedure
        set out in Clause 30.5 (Procedure
        for transfer) is complied with and
        if the New Lender has, prior to the Transfer Date, entered into a Confidentiality
    Undertaking with the Company.
	 	 	 	 
	 	30.2.7	If:	 
	 	 	 	 
	 	 	(a)	a Lender assigns or transfers
        any of its rights or obligations under the Finance Documents or changes
    its Facility Office; and
	 	 	 	 
	 	 	(b)	as a result of circumstances
        existing at the date the assignment, transfer or change occurs, an Obligor
        would be obliged to make a payment (or increased payment) to the New
        Lender or Lender acting through its new Facility Office under Clause
        19 (Tax gross-up and indemnities)
    or Clause 20 (Increased costs),xx
	 	 	 	 
	 	 	then the New Lender or Lender acting
        through its new Facility Office is only entitled to receive payment (or
        increased payment) under those Clauses to the same extent as the Existing
        Lender or Lender acting through its previous Facility Office would have
        been if the assignment, transfer or change had not occurred provided
        that (without prejudice to Clause
        19.2.8 above) this sub-clause 30.2.7 shall not prevent an Obligor from
        being required to pay an increased amount under Clause 19 (Tax
        Gross Up and Indemnities) to a Treaty
    Lender which becomes a Lender on the Syndication Date.
	 	 	 	 
	30.3	Assignment or transfer
    fee
	 	The New Lender shall,
        on the date upon which an assignment or transfer takes effect, pay to
    the Facility Agent (for its own account) a fee of US$3,000.
	 	 
	30.4	Limitation of responsibility
    of Existing Lenders
	 	30.4.1	Unless expressly agreed
        to the contrary, an Existing Lender makes no representation or warranty
    and assumes no responsibility to a New Lender for:
	 	 	 	 
	 	 	(a)	the legality, validity, effectiveness,
    adequacy or enforceability of the Finance Documents or any other documents;
	 	 	 	 
	 	 	(b)	the financial condition of any Obligor;

 

 - 82 -

	 	 	(c)	the performance and observance
        by any Obligor of its obligations under the Finance Documents or any
    other documents; or
	 	 	 	 
	 	 	(d)	the accuracy of any statements
        (whether written or oral) made in or in connection with any Finance Document
    or any other document,
	 	 	 	 
	 	 	and any representations or warranties
    implied by law are excluded.
	 	 	 	 
	 	30.4.2	Each New Lender confirms
    to the Existing Lender and the other Finance Parties that it:
	 	 	 	 
	 	 	(a)	has made (and shall continue to make) its own
        independent investigation and assessment of the financial condition and
        affairs of each Obligor and its related entities in connection with its
        participation in this Agreement and has not relied exclusively on any
        information provided to it by the Existing Lender in connection with
    any Finance Document; and
	 	 	 	 
	 	 	(b)	will continue to make its own independent appraisal
        of the creditworthiness of each Obligor and its related entities whilst
        any amount is or may be outstanding under the Finance Documents or any
    Commitment is in force.
	 	 	 	 
	 	30.4.3	Nothing in any Finance
    Document obliges an Existing Lender to:
	 	 	 	 
	 	 	(a)	accept a re-transfer from a New Lender of any
        of the rights and obligations assigned or transferred under this Clause
    30; or
	 	 	 	 
	 	 	(b)	support any losses directly or indirectly incurred
        by the New Lender by reason of the non-performance by any Obligor of
    its obligations under the Finance Documents or otherwise.
	 	 	 	 
	30.5	Procedure for transfer
	 	30.5.1	Subject to the conditions
        set out in Clause 30.2 (Conditions
        of assignment or transfer) a transfer
        is effected in accordance with sub-clause 30.5.3 below when the Facility
        Agent executes an otherwise duly completed Transfer Certificate delivered
        to it by the Existing Lender and the New Lender. The Facility Agent shall,
        subject to sub-clause 30.5.2 below, as soon as reasonably practicable
        after receipt by it of a duly completed Transfer Certificate appearing
        on its face to comply with the terms of this Agreement and delivered
        in accordance with the terms of this Agreement, execute that Transfer
    Certificate.
	 	 	 
	 	30.5.2	The Facility Agent
        shall only be obliged to execute a Transfer Certificate delivered to
        it by the Existing Lender and the New Lender once it is reasonably satisfied
        it has complied with all necessary "know your customer" or other similar
        checks under all applicable laws and regulations in relation to the transfer
    to such New Lender.
	 	 	 
	 	30.5.3	On the Transfer Date:
	 	 	 	 
	 	 	(a) 	to the extent that in the Transfer Certificate
        the Existing Lender seeks to transfer by novation its rights and obligations
    under the Finance Documents 

 - 83 -

	 	 	 	each of the Obligors and the Existing
        Lender shall be released from further obligations towards one another
        under the Finance Documents and their respective rights against one another
        under the Finance Documents shall be cancelled (being the "Discharged
        Rights and Obligations"); 
	 	 	 	 
	 	 	(b)	each of the Obligors and the New
        Lender shall assume obligations towards one another and/or acquire rights
        against one another which differ from the Discharged Rights and Obligations
        only insofar as that Obligor and the New Lender have assumed and/or acquired
        the same in place of that Obligor and the Existing Lender; 
	 	 	 	 
	 	 	(c)	the Facility Agent, the Arranger,
        the New Lender and other Lenders shall acquire the same rights and assume
        the same obligations between themselves as they would have acquired and
        assumed had the New Lender been an Original Lender with the rights and/or
        obligations acquired or assumed by it as a result of the transfer and
        to that extent the Facility Agent, the Arranger and the Existing Lender
        shall each be released from further obligations to each other under the
        Finance Documents; and 
	 	 	 	 
	 	 	(d)	the New Lender shall become a Party
        as a "Lender". 

	30.6	Copy of Transfer Certificate
          to Company 
	 	The Facility Agent shall,
        as soon as reasonably practicable after it has executed a Transfer Certificate,
        send to the Company a copy of that Transfer Certificate. 
	 	 
	30.7	Disclosure of information 
	 	Any Lender may disclose
        to any of its Affiliates and any other person: 

 

	 	30.7.1	to (or through) whom that Lender
        assigns or transfers (or may potentially assign or transfer) all or any
        of its rights and obligations under this Agreement; 
	 	 	 
	 	30.7.2	with (or through) whom that Lender
        enters into (or may potentially enter into) any sub-participation in
        relation to, or any other transaction under which payments are to be
        made by reference to, this Agreement or any Obligor; or 
	 	 	 
	 	30.7.3	to whom, and to the extent that,
        information is required to be disclosed by any applicable law or regulation, 
	 	 	 
	 	any information about any Obligor,
        the Group and the Finance Documents as that Lender shall consider appropriate
        if, in relation to sub-clauses 30.7.1 and 30.7.2 above, the person to
        whom the information is to be given has entered into a Confidentiality
        Undertaking with that Lender prior to the disclosure of the information
    the subject of the Confidentiality Undertaking.
	 	 	 
	31.	CHANGES TO THE OBLIGORS
	 	 	 
	31.1	Assignment and transfers by Obligors
	 	No Obligor may assign any of its
        rights or transfer any of its rights or obligations under the Finance
    Documents.

 - 84 -

	
31.2	Additional Borrowers
	 	
31.2.1	Subject to compliance with the provisions
        of sub-clauses 26.6.3 and 26.6.4 of Clause 26.6 ("Know
        your customer" checks), the Company
        may request that any of its Subsidiaries becomes an Additional Borrower.
    That Subsidiary shall become an Additional Borrower if:
	 	 	 	 
	 	 	
(a)	
all the Lenders approve the addition of that Subsidiary (which approval is not to be unreasonably withheld) other than in the case of a Subsidiary incorporated in the United Kingdom or the United States of America, in which
case no approval by the Lenders is required;     
	 	 	 	 
	 	 	
(b)	
the Company delivers to the Facility Agent a duly completed and executed Accession Letter;     
	 	 	 	 
	 	 	
(c)	
the Company confirms that no Default is continuing or will occur as a result of that Subsidiary becoming an Additional Borrower; and   
	 	 	 	 
	 	 	
(d)	
the Facility Agent has received all of the documents and other evidence listed in Part III of Schedule 2 (Conditions precedent) in relation to that
Additional Borrower, each in form and substance satisfactory to the Facility Agent, acting reasonably.   
	 	 	 	 
	 	
31.2.2	The Facility Agent shall notify the
        Company and the Lenders promptly upon being satisfied that it has received
        (in form and substance satisfactory to it) all the documents and other
        evidence listed in Part III of Schedule 2 (Conditions
    precedent). 
	 	 	 	 
	
31.3	Resignation of a Borrower
	 	
31.3.1	The Company may request that a Borrower
        (other than the Company) ceases to be a Borrower by delivering to the
    Facility Agent a Resignation Letter.
	 	 	 	 
	 	
31.3.2	The Facility Agent shall accept a
        Resignation Letter and notify the Company and the Lenders of its acceptance
    if:
	 	 	 	 
	 	 	
(a)	
no Default is continuing or will result from the acceptance of the Resignation Letter (and the Company has confirmed this is the case); and    
	 	 	 	 
	 	 	
(b)	
the Borrower is under no actual or contingent obligations as a Borrower under any Finance Documents,   
	 	 	 	 
	 	 	whereupon that company shall cease to
    be a Borrower and shall have no further rights or obligations under the Finance
    Documents.
	 	 	 	 
	
31.4	Additional Guarantors
	 	
31.4.1	Subject to compliance with the provisions
        of sub-clauses 26.6.3 and 26.6.4 of Clause 26.6 ("Know
        your customer" checks), the Company
        may request that any of its Subsidiaries become an Additional Guarantor.
    That Subsidiary shall become an Additional Guarantor if:

- 85 -

	 	 	(a) 	the Company (or the Company, in
    the case of New Holdco) delivers to the Facility Agent a duly completed and
    executed Accession Letter; and
	 	 	 	 
	 	 	(b)	the Facility Agent has received
        all of the documents and other evidence listed in Part III of Schedule
        2 (Conditions precedent)
        in relation to that Additional Guarantor, each in form and substance
    reasonably satisfactory to the Facility Agent.
	 	 	 
	 	31.4.2	The Facility Agent
        shall notify the Company and the Lenders promptly upon being satisfied
        that it has received (in form and substance satisfactory to it) all the
        documents and other evidence listed in Part III of Schedule 2 (Conditions
    precedent).
	 	 	 
	31.5	Repetition of Representations
	 	Delivery of an Accession
        Letter constitutes confirmation by the relevant Subsidiary (or New Holdco,
        as the case may be) that the Repeating Representations are true and correct
        in relation to it as at the date of delivery as if made by reference
    to the facts and circumstances then existing.
	 	 
	31.6	Resignation of
    a Guarantor
	 	31.6.1	The Company may request that a
        Guarantor (other than the Company) ceases to be a Guarantor by delivering
    to the Facility Agent a Resignation Letter.
	 	 	 
	 	31.6.2	The Facility Agent
        shall accept a Resignation Letter and notify the Company and the Lenders
    of its acceptance if:
	 	 	 
	 	 	(a)	no Default is continuing or will result from
        the acceptance of the Resignation Letter (and the Company has confirmed
    this is the case); and
	 	 	 	 
	 	 	(b)	(other than in relation to the resignation
        of the Company as a guarantor) all the Lenders have consented to the
    Company's request.

- 86 -

SECTION 10

THE FINANCE PARTIES

	
32.	
ROLE OF THE AGENT AND THE ARRANGER      
	 	 	 
	
32.1	
Appointment of the Agent        
	 	
32.1.1	
Each other Finance Party appoints each of the Agents to act as its agent under and in connection with the Finance Documents.   
	 	 	 
	 	
32.1.2	
Each other Finance Party authorises each Agent to exercise the rights, powers, authorities and discretions specifically given to that Agent under or in connection with the Finance Documents together with any other
incidental rights, powers, authorities and discretions.  
	 	 	 
	
32.2	
Duties of the Agent     
	 	
32.2.1	
An Agent shall promptly forward to a Party the original or a copy of any document which is delivered to the Agent for that Party by any other Party.   
	 	 	 
	 	
32.2.2	
Except where a Finance Document specifically provides otherwise, an Agent is not obliged to review or check the adequacy, accuracy or completeness of any document it forwards to another Party.       
	 	 	 
	 	
32.2.3	
If an Agent receives notice from a Party referring to this Agreement, describing a Default and stating that the circumstance described is a Default, it shall promptly notify the other Finance Parties.       
	 
	 	
32.2.4	
If an Agent is aware of the non-payment of any principal, interest, commitment fee or other fee payable to a Finance Party (other than the Agents or the Arranger) under this Agreement it shall promptly notify the other
Finance Parties. 
	 	 	 
	 	
32.2.5	
Each Agent's duties under the Finance Documents are solely mechanical and administrative in nature.    
	 	 	 
	
32.3	
Role of the Arranger    
	 	
Except as specifically provided in the Finance Documents, the Arranger has no obligations of any kind to any other Party under or in connection with any Finance Document.     
	 
	
32.4	
No fiduciary duties     
	 	
32.4.1	
Nothing in this Agreement constitutes any Agent or the Arranger as a trustee or fiduciary of any other person. 
	 	 	 
	 	
32.4.2	
Neither an Agent nor the Arranger shall be bound to account to any Lender for any sum or the profit element of any sum received by it for its own account.     
	 	 	 
	
32.5	
Business with the Group 
	 	
An Agent and the Arranger may accept deposits from, lend money to and generally engage in any kind of banking or other business with any member of the Group.  
	 	 	 
	
32.6	
Rights and discretions of the Agent     
	 	
32.6.1	
An Agent may rely on:  

- 87 -

	 	 	(a)	any representation, notice or document
    believed by it to be genuine, correct and appropriately authorised; and
	 	 	 	 
	 	 	(b)	any statement made by a director,
        authorised signatory or employee of any person regarding any matters
        which may reasonably be assumed to be within his knowledge or within
    his power to verify.

	 	
32.6.2	An Agent may assume (unless it has
        received notice to the contrary in its capacity as agent for the Lenders)
    that:
	 	 	 	 
	 	 	
(a)	
no Default has occurred (unless it has actual knowledge of a Default arising under Clause 29.1 (Non-payment));        
	 	 	 	 
	 	 	
(b)	
any right, power, authority or discretion vested in any Party or the Majority Lenders has not been exercised; and      
	 	 	 	 
	 	 	
(c)	
any notice or request made by the Company (other than a Utilisation Request) is made on behalf of and with the consent and knowledge of all the Obligors.      
	 	 	 	 
	 	
32.6.3	An Agent may engage, pay for and
        rely on the advice or services of any lawyers, accountants, surveyors
    or other experts.
	 	 	 	 
	 	
32.6.4	An Agent may act in relation to the
    Finance Documents through its personnel and agents.
	 	 	 	 
	 	
32.6.5	An Agent may disclose to any other
        Party any information it reasonably believes it has received as agent
    under this Agreement.
	 	 	 	 
	 	
32.6.6	Notwithstanding any other provision
        of any Finance Document to the contrary, neither an Agent nor the Arranger
        is obliged to do or omit to do anything if it would or might in its reasonable
        opinion constitute a breach of any law or regulation or a breach of a
    fiduciary duty or duty of confidentiality.
	 	 	 	 
	
32.7	Majority Lenders' instructions
	 	
32.7.1	Unless a contrary indication appears
        in a Finance Document, each Agent shall (i) exercise any right, power,
        authority or discretion vested in it as Agent in accordance with any
        instructions given to it by the Majority Lenders (or, if so instructed
        by the Majority Lenders, refrain from exercising any right, power, authority
        or discretion vested in it as Agent) and (ii) not be liable for any act
        (or omission) if it acts (or refrains from taking any action) in accordance
    with an instruction of the Majority Lenders.
	 	 	 	 
	 	
32.7.2	Unless a contrary indication appears
        in a Finance Document, any instructions given by the Majority Lenders
    will be binding on all the Finance Parties.
	 	 	 	 
	 	
32.7.3	An Agent may refrain from acting
        in accordance with the instructions of the Majority Lenders (or, if appropriate,
        the Lenders) until it has received such security as it may require for
        any cost, loss or liability (together with an amount in respect of any
    associated VAT) which it may incur in complying with the instructions.

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32.7.4	
In the absence of instructions from the Majority Lenders, (or, if appropriate, the Lenders) each Agent may act (or refrain from taking action) as it considers to be in the best interest of the Lenders.      
	 	 	 
	 	
32.7.5	
An Agent is not authorised to act on behalf of a Lender (without first obtaining that Lender's consent) in any legal or arbitration proceedings relating to any Finance Document.      
	 	 	 
	
32.8	Responsibility for documentation
	 	Neither an Agent nor the Arranger:
	 	 	 
	 	
32.8.1	
is responsible for the adequacy, accuracy and/or completeness of any information (whether oral or written) supplied by the Agent, the Arranger, an Obligor or any other person given in or in connection with any Finance
Document or the Information Memorandum; or       
	 	 	 
	 	
32.8.2	
is responsible for the legality, validity, effectiveness, adequacy or enforceability of any Finance Document or any other agreement, arrangement or document entered into, made or executed in anticipation of or in connection
with any Finance Document.       
	 	 	 
	
32.9	Exclusion of liability
	 	
32.9.1	
Without limiting sub-clause 32.9.2 below, an Agent will not be liable for any action taken by it under or in connection with any Finance Document, unless directly caused by its gross negligence or wilful
misconduct.      
	 	 	 
	 	
32.9.2	
No Party (other than an Agent) may take any proceedings against any officer, employee or agent of the Agent in respect of any claim it might have against the Agent or in respect of any act or omission of any kind by that
officer, employee or agent in relation to any Finance Document and any officer, employee or agent of the Agent may rely on this Clause subject to Clause 1.4 (Third Party Rights) and the provisions of the Third Parties Act.      
	 	 	 
	 	
32.9.3	
No Agent will be liable for any delay (or any related consequences) in crediting an account with an amount required under the Finance Documents to be paid by the Agent if the Agent has taken all necessary steps as soon as
reasonably practicable to comply with the regulations or operating procedures of any recognised clearing or settlement system used by the Agent for that purpose.        
	 	 	 
	 	
32.9.4	
Nothing in this Agreement shall oblige an Agent or the Arranger to carry out any "know your customer" or other checks in relation to any person on behalf of any Lender and each Lender confirms to the Agent and the Arranger
that it is solely responsible for any such checks it is required to carry out and that it may not rely on any statement in relation to such checks made by the Agent or the Arranger.    
	 	 	 
	
32.10	Lenders' indemnity to the Agent
	 	Each Lender shall (in proportion to its
    share of the Total Commitments or, if the Total Commitments are then zero,
    to its share of the Total Commitments immediately prior to their

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	 	reduction to zero) indemnify each Agent,
    within three Business Days of demand, against any cost, loss or liability
    incurred by the Agent (otherwise than by reason of the Agent's gross negligence
    or wilful misconduct) in acting as Agent under the Finance Documents (unless
    the Agent has been reimbursed by an Obligor pursuant to a Finance Document).
	 	 	 
	
32.11 	Resignation of the Agent
	 	
32.11.1 	
An Agent may resign and appoint one of its Affiliates as successor by giving notice to the other Finance Parties and the Company.      
	 	 	 
	 	
32.11.2 	
Alternatively an Agent may resign by giving notice to the other Finance Parties and the Company, in which case the Majority Lenders (after consultation with the Company) may appoint a successor Agent.       
	 	 	 
	 	
32.11.3 	
If the Majority Lenders have not appointed a successor Agent in accordance with sub-clause 32.11.2 above within 30 days after notice of resignation was given, the Agent (after consultation with the Company) may appoint a
successor Agent. 
	 	 	 
	 	
32.11.4	
The retiring Agent shall, at its own cost, make available to the successor Agent such documents and records and provide such assistance as the successor Agent may reasonably request for the purposes of performing its
functions as Agent under the Finance Documents.  
	 	 	 
	 	
32.11.5	
The Agent's resignation notice shall only take effect upon the appointment of a successor.     
	 	 	 
	 	
32.11.6	
Upon the appointment of a successor, the retiring Agent shall be discharged from any further obligation in respect of the Finance Documents but shall remain entitled to the benefit of this Clause 32. Its successor and each
of the other Parties shall have the same rights and obligations amongst themselves as they would have had if such successor had been an original Party.  
	 	 	 
	 	
32.11.7	
After consultation with the Company, the Majority Lenders may, by notice to the Agent, require it to resign in accordance with sub-clause 32.11.2 above. In this event, the Agent shall resign in accordance with sub-clause
32.11.2 above.   
	 	 	 
	
32.12	
Confidentiality 
	 	
32.12.1 	
In acting as agent for the Finance Parties, each Agent shall be regarded as acting through its agency division which shall be treated as a separate entity from any other of its divisions or departments.     
	 
	 	
32.12.2	
If information is received by another division or department of the Agent, it may be treated as confidential to that division or department and the Agent shall not be deemed to have notice of it.    
	 	 	 
	
32.13	Relationship with the Lenders
	 	
32.13.1 	
Each Agent may treat each Lender as a Lender, entitled to payments under this Agreement and acting through its Facility Office unless it has received not less than five Business Days prior notice from that Lender to the
contrary in accordance with the terms of this Agreement. 

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32.13.2 	
Each Lender shall supply the Facility Agent with any
information required by the Facility Agent in order to calculate the Mandatory
Cost in accordance with Schedule 4 (Mandatory
Cost formulae).

	32.14	Credit appraisal by the Lenders
	 	Without affecting
        the responsibility of any Obligor for information supplied by it or on
        its behalf in connection with any Finance Document, each Lender confirms
        to each Agent and the Arranger that it has been, and will continue to
        be, solely responsible for making its own independent appraisal and investigation
        of all risks arising under or in connection with any Finance Document
    including but not limited to:
	 	 	 
	 	32.14.1	the financial condition, status and nature
    of each member of the Group;
	 	 	 
	 	32.14.2	the legality, validity, effectiveness, adequacy
        or enforceability of any Finance Document and any other agreement, arrangement
        or document entered into, made or executed in anticipation of, under
    or in connection with any Finance Document;
	 	 	 
	 	32.14.3	whether that Lender has recourse, and the nature
        and extent of that recourse, against any Party or any of its respective
        assets under or in connection with any Finance Document, the transactions
        contemplated by the Finance Documents or any other agreement, arrangement
        or document entered into, made or executed in anticipation of, under
    or in connection with any Finance Document; and
	 	 	 
	 	32.14.4	the adequacy, accuracy and/or completeness
        of the Information Memorandum and any other information provided by the
        Agent, any Party or by any other person under or in connection with any
        Finance Document, the transactions contemplated by the Finance Documents
        or any other agreement, arrangement or document entered into, made or
        executed in anticipation of, under or in connection with any Finance
    Document.
	 	 
	32.15	Reference Banks
	 	If a Reference Bank (or, if a Reference Bank
        is not a Lender, the Lender of which it is an Affiliate) ceases to be
        a Lender, the Facility Agent shall (in consultation with the Company)
        appoint another Lender or an Affiliate of a Lender to replace that Reference
    Bank.
	 	 	 
	32.16	Agent's Management
    Time
	 	Any amount payable to an Agent under Clause
        21.3 (Indemnity to the Facility Agent),
        Clause 23 (Costs
        and expenses) and Clause 32.10 (Lenders'
        indemnity to the Agent) shall include
        the cost of utilising the Agent's extraordinary
        management time or other extraordinary resources not contemplated at
        the date of this Agreement (in connection with any Default, any request
        for or granting of a waiver or consent, or amendment to a Finance Document
        or the preservation or enforcement of any right arising under the Finance
        Documents) and will be calculated on the basis of such reasonable daily
        or hourly rates as the Agent may notify to the Company and the Lenders,
        and is in addition to any fee paid or payable to the Agent under Clause
    18 (Fees).

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	32.17	Deduction from amounts payable
    by the Agent
	 	If any Party owes
        an amount to an Agent under the Finance Documents the Agent may, after
        giving notice to that Party, deduct an amount not exceeding that amount
        from any payment to that Party which the Agent would otherwise be obliged
        to make under the Finance Documents and apply the amount deducted in
        or towards satisfaction of the amount owed. For the purposes of the Finance
        Documents that Party shall be regarded as having received any amount
    so deducted.
	 	 
	32.18	USA Patriot Act
	 	Each Lender hereby
        notifies each Obligor that pursuant to the requirements of the USA Patriot
        Act, such Lender is required to obtain, verify and record information
        that identifies such Obligor, which information includes the name and
        address of such Obligor and other information that will allow such Lender
    to identity such Obligor in accordance with the USA Patriot Act.
	 	 
	33.	CONDUCT OF BUSINESS
    BY THE FINANCE PARTIES
	 	 
	 	No provision of this
    Agreement will:
	 	 
	 	33.1.1	interfere with the right of any
        Finance Party to arrange its affairs (Tax or otherwise) in whatever manner
    it thinks fit;
	 	 	 
	 	33.1.2	oblige any Finance Party to investigate
        or claim any credit, relief, remission or repayment available to it or
    the extent, order and manner of any claim; or
	 	 	 
	 	33.1.3	oblige any Finance Party to disclose any information
        relating to its affairs (Tax or otherwise) or any computations in respect
    of Tax.
	 	 
	34.	SHARING AMONG THE FINANCE PARTIES
	 	 	 
	34.1	Payments to Finance Parties
	 	If a Finance Party (a "Recovering
          Finance Party") receives or recovers
          any amount from an Obligor other than in accordance with Clause 35
          (Payment mechanics)
          and applies that amount to a payment due under the Finance Documents
    then:
	 	 	 
	 	34.1.1	the Recovering Finance Party shall, within
        three Business Days, notify details of the receipt or recovery, to the
    relevant Agent;
	 	 	 
	 	34.1.2	that Agent shall determine whether the receipt
        or recovery is in excess of the amount the Recovering Finance Party would
        have been paid had the receipt or recovery been received or made by the
        Agent and distributed in accordance with Clause 35 (Payment
        mechanics), without taking account
        of any Tax which would be imposed on the Agent in relation to the receipt,
    recovery or distribution; and
	 	 	 
	 	34.1.3	the Recovering Finance Party shall, within
        three Business Days of demand by that Agent, pay to the Agent an amount
        (the "Sharing Payment")
        equal to such receipt or recovery less any amount which the Agent determines
        may be retained by the Recovering Finance Party as its share of any payment
        to be made, in accordance with Clause 35.5 (Partial
    payments).

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	34.2	Redistribution
    of payments
	 	The relevant Agent
        shall treat the Sharing Payment as if it had been paid by the relevant
        Obligor and distribute it between the Finance Parties (other than the
        Recovering Finance Party) in accordance with Clause 35.5 (Partial
    payments). 
	 	 
	34.3	Recovering Finance
    Party's rights
	 	34.3.1	On a distribution by an Agent under
        Clause 34.2 (Redistribution of payments),
        the Recovering Finance Party will be subrogated to the rights of the
    Finance Parties which have shared in the redistribution.
	 	 	 
	 	34.3.2	If and to the extent
        that the Recovering Finance Party is not able to rely on its rights under
        sub-clause 34.3.1 above, the relevant Obligor shall be liable to the
        Recovering Finance Party for a debt equal to the Sharing Payment which
    is immediately due and payable.
	 	 
	34.4	Reversal of redistribution
	 	If any part of the
        Sharing Payment received or recovered by a Recovering Finance Party becomes
    repayable and is repaid by that Recovering Finance Party, then:
	 	 	 
	 	34.4.1	each Finance Party which has received
        a share of the relevant Sharing Payment pursuant to Clause 34.2 (Redistribution
        of payments) shall, upon request
        of the relevant Agent, pay to that Agent for account of that Recovering
        Finance Party an amount equal to the appropriate part of its share of
        the Sharing Payment (together with an amount as is necessary to reimburse
        that Recovering Finance Party for its proportion of any interest on the
        Sharing Payment which that Recovering Finance Party is required to pay);
    and
	 	 	 
	 	34.4.2	that Recovering Finance
        Party's rights of subrogation in respect of any reimbursement shall be
        cancelled and the relevant Obligor will be liable to the reimbursing
    Finance Party for the amount so reimbursed.
	 	 	 
	34.5	Exceptions
	 	34.5.1	This Clause 34 shall not apply
        to the extent that the Recovering Finance Party would not, after making
        any payment pursuant to this Clause, have a valid and enforceable claim
    against the relevant Obligor.
	 	 	 
	 	34.5.2	A Recovering Finance
        Party is not obliged to share with any other Finance Party any amount
        which the Recovering Finance Party has received or recovered as a result
    of taking legal or arbitration proceedings, if:
	 	 	 
	 	 	(a)	it notified that other Finance
    Party of the legal or arbitration proceedings; and
	 	 	 	 
	 	 	(b)	that other Finance Party had an opportunity
        to participate in those legal or arbitration proceedings but did not
        do so as soon as reasonably practicable having received notice and did
    not take separate legal or arbitration proceedings.

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SECTION 11

ADMINISTRATION

	35.	PAYMENT MECHANICS
	 	 
	35.1	Payments to each
    Agent
	 	35.1.1	On each date on which an Obligor
        or a Lender is required to make a payment under a Finance Document, that
        Obligor or Lender shall make the same available to the relevant Agent
        (unless a contrary indication appears in a Finance Document) for value
        on the due date at the time and in such funds specified by the relevant
        Agent as being customary at the time for settlement of transactions in
    the relevant currency in the place of payment.
	 	 	 
	 	35.1.2	Payment shall be made to such account
        in the principal financial centre of the country of that currency (or,
        in relation to euro, in a principal financial centre in a Participating
    Member State or London) with such bank as the relevant Agent specifies.
	 	 
	35.2	Distributions by
    the Agent
	 	Each payment received
        by an Agent under the Finance Documents for another Party shall, subject
        to Clause 35.3 (Distributions to
        an Obligor), Clause 35.4 (Clawback)
        and Clause 32.17 (Deduction
        from amounts payable by the Agent)
        be made available by the Agent as soon as practicable after receipt to
        the Party entitled to receive payment in accordance with this Agreement
        (in the case of a Lender, for the account of its Facility Office), to
        such account as that Party may notify to the Agent by not less than five
        Business Days' notice with a bank in the principal financial centre of
        the country of that currency (or, in relation to euro, in the principal
    financial centre of a Participating Member State or London).
	 	 
	35.3	Distributions to
    an Obligor
	 	An Agent may (with
        the consent of the Obligor or in accordance with Clause 36 (Set-off))
        apply any amount received by it for that Obligor in or towards payment
        (on the date and in the currency and funds of receipt) of any amount
        due from that Obligor under the Finance Documents or in or towards purchase
    of any amount of any currency to be so applied.
	 	 
	35.4	Clawback
	 	35.4.1	Where a sum is to be paid to an
        Agent under the Finance Documents for another Party, an Agent is not
        obliged to pay that sum to that other Party (or to enter into or perform
        any related exchange contract) until it has been able to establish to
    its satisfaction that it has actually received that sum.
	 	 	 
	 	35.4.2	If the Agent pays an amount to another Party
        and it proves to be the case that the Agent had not actually received
        that amount, then the Party to whom that amount (or the proceeds of any
        related exchange contract) was paid by the Agent shall on demand refund
        the same to the Agent together with interest on that amount from the
        date of payment to the date of receipt by the Agent, calculated by the
    Agent to reflect its cost of funds.

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	35.5	Partial payments
	 	35.5.1	If an Agent receives
        a payment that is insufficient to discharge all the amounts then due
        and payable by an Obligor under the Finance Documents, the Agent shall
        apply that payment towards the obligations of that Obligor under the
    Finance Documents in the following order:
	 	 	 	 
	 	 	(a)	first,
        in or towards payment pro rata of
        any unpaid fees, costs and expenses of each Agent and the Arranger under
    the Finance Documents;
	 	 	 	 
	 	 	(b)	secondly,
        in or towards payment pro rata of
    any accrued interest, fee or commission due but unpaid under this Agreement;
	 	 	 	 
	 	 	(c)	thirdly,
        in or towards payment pro rata of
    any principal due but unpaid under this Agreement; and
	 	 	 	 
	 	 	(d)	fourthly,
        in or towards payment pro rata of
    any other sum due but unpaid under the Finance Documents.
	 	 	 	 
	 	35.5.2	An Agent shall, if
        so directed by the Majority Lenders, vary the order set out in paragraphs
    (a) to (d) of sub-clause 35.5.1 above.
	 	 	 
	 	35.5.3	Sub-clauses 35.5.1
    and 35.5.2 and above will override any appropriation made by an Obligor.
	 	 	 
	35.6	No set-off by Obligors
	 	All payments to be
        made by an Obligor under the Finance Documents shall be calculated and
        be made without (and free and clear of any deduction for) set-off or
    counterclaim.
	 	 
	35.7	Business Days
	 	35.7.1	Any payment which
        is due to be made on a day that is not a Business Day shall be made on
        the next Business Day in the same calendar month (if there is one) or
    the preceding Business Day (if there is not).
	 	 	 
	 	35.7.2	During any extension
        of the due date for payment of any principal or Unpaid Sum under this
        Agreement interest is payable on the principal or Unpaid Sum at the rate
    payable on the original due date.
	 	 	 
	35.8	Currency of account
	 	35.8.1	Subject to sub-clauses 35.8.2 to 35.8.5 below,
        the Base Currency is the currency of account and payment for any sum
    due from an Obligor under any Finance Document.
	 	 	 
	 	35.8.2	A repayment of a Loan
        or Unpaid Sum or a part of a Loan or Unpaid Sum shall be made in the
    currency in which that Loan or Unpaid Sum is denominated on its due date.
	 	 	 
	 	35.8.3	Each payment of interest
        shall be made in the currency in which the sum in respect of which the
    interest is payable was denominated when that interest accrued.

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	 	35.8.4	Each payment in respect
        of costs, expenses or Taxes shall be made in the currency in which the
    costs, expenses or Taxes are incurred.
	 	 	 
	 	35.8.5	Any amount expressed
        to be payable in a currency other than the Base Currency shall be paid
    in that other currency.
	 	 
	35.9	Change of currency
	 	35.9.1	Unless otherwise prohibited by
        law, if more than one currency or currency unit are at the same time
        recognised by the central bank of any country as the lawful currency
    of that country, then:
	 	 	 	 
	 	 	(a)	any reference in the Finance Documents
        to, and any obligations arising under the Finance Documents in, the currency
        of that country shall be translated into, or paid in, the currency or
        currency unit of that country designated by the Facility Agent (after
    consultation with the Company); and
	 	 	 	 
	 	 	(b)	any translation from one currency
        or currency unit to another shall be at the official rate of exchange
        recognised by the central bank for the conversion of that currency or
        currency unit into the other, rounded up or down by the Facility Agent
    (acting reasonably).
	 	 	 
	 	35.9.2	If a change in any currency of a country occurs,
        this Agreement will, to the extent the Facility Agent (acting reasonably
        and after consultation with the Company) specifies to be necessary, be
        amended to comply with any generally accepted conventions and market
        practice in the Relevant Interbank Market and otherwise to reflect the
    change in currency.
	 	 
	36.	SET-OFF
	 	 
	 	A Finance Party may
        set off any matured obligation due from an Obligor under the Finance
        Documents (to the extent beneficially owned by that Finance Party) against
        any matured obligation owed by that Finance Party to that Obligor, regardless
        of the place of payment, booking branch or currency of either obligation.
        If the obligations are in different currencies, the Finance Party may
        convert either obligation at a market rate of exchange in its usual course
    of business for the purpose of the set-off.
	 	 
	37	NOTICES
	 	 
	37.1	Communications
    in writing
	 	Any communication
        to be made under or in connection with the Finance Documents shall be
    made in writing and, unless otherwise stated, may be made by fax or letter.
	 	 
	37.2	Addresses
	 	The address and fax
        number (and the department or officer, if any, for whose attention the
        communication is to be made) of each Party for any communication or document
        to be made or delivered under or in connection with the Finance Documents
    is:
	 	 
	 	37.2.1	in the case of the
    Company, that identified with its name below;

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37.2.2	
in the case of each Lender or any other Original Obligor, that notified in writing to the Facility Agent on or prior to the date on which it becomes a Party; and      
	 	 	 
	 	
37.2.3	
in the case of an Agent, that identified with its name below,  
	 
	 	
or any substitute address or fax number or department or officer as the Party may notify to the Facility Agent (or the Facility Agent may notify to the other Parties, if a change is made by the Facility Agent) by not less
than five Business Days' notice. 
	 
	
37.3	
Delivery        
	 	
37.3.1	
Any communication or document made or delivered by one person to another under or in connection with the Finance Documents will only be effective:     

	 	 	
(a)	
if by way of fax, when received in legible form; or    
	 
	 	 	
(b)	
if by way of letter, when it has been left at the relevant address or five Business Days after being deposited in the post postage prepaid in an envelope addressed to it at that address,     
	 
	 	 	
and, if a particular department or officer is specified as part of its address details provided under Clause 37.2 (Addresses), if addressed to that
department or officer.   
	 
	 	
37.3.2	
Any communication or document to be made or delivered to an Agent will be effective only when actually received by the Agent and then only if it is expressly marked for the attention of the department or officer identified
with the Agent's signature below (or any substitute department or officer as the Agent shall specify for this purpose).  
	 
	 	
37.3.3	
All notices from or to an Obligor shall be sent through an Agent.      
	 
	 	
37.3.4	
Any communication or document made or delivered to the Company in accordance with this Clause will be deemed to have been made or delivered to each of the Obligors.   
	 
	
37.4	
Notification of address and fax number  
	 	
Promptly upon receipt of notification of an address and fax number or change of address or fax number pursuant to Clause 37.2 (Addresses) or changing
its own address or fax number, the Facility Agent shall notify the other Parties.        
	 
	
37.5	
Electronic communication        
	 	
37.5.1	
Any communication to be made between an Agent and a Lender under or in connection with the Finance Documents may be made by electronic mail or other electronic means, if that Agent and the relevant Lender:  
	 
	 	 	
(a)	
agree that, unless and until notified to the contrary, this is to be an accepted form of communication;        
	 
	 	 	
(b)	
notify each other in writing of their electronic mail address and/or any other information required to enable the sending and receipt of information by that means; and        
	 

- 97 -

	 	 	(c) 	 notify each other of any change
    to their address or any other such information  supplied by them. 
	 
	 	
37.5.2	
Any electronic communication made between an Agent and a Lender will be effective only when actually received in readable form and in the case of any electronic communication made by a Lender to that Agent only if it is
addressed in such a manner as the Agent shall specify for this purpose.  
	 
	
37.6	
English language        
	 	
37.6.1	
Any notice given under or in connection with any Finance Document must be in English.  
	 
	 	
37.6.2	
All other documents provided under or in connection with any Finance Document must be: 
	 
	 	 	
(a)	
in English; or 
	 
	 	 	
(b)	
if not in English, and if so required by the Facility Agent, accompanied by a certified English translation and, in this case, the English translation will prevail unless the document is a constitutional, statutory or other
official document.       
	 
	
38.	
CALCULATIONS AND CERTIFICATES   
	 
	
38.1	
Accounts        
	 	
In any litigation or arbitration proceedings arising out of or in connection with a Finance Document, the entries made in the accounts maintained by a Finance Party are prima facie
evidence of the matters to which they relate.       
	 
	
38.2	
Certificates and Determinations 
	 	
Any certification or determination by a Finance Party of a rate or amount under any Finance Document is, in the absence of manifest or proven error, prima facie evidence of the matters to which it relates.        
	 
	
38.3	
Day count convention    
	 	
Any interest, commission or fee accruing under a Finance Document will accrue from day to day and is calculated on the basis of the actual number of days elapsed and a year of 360 days or, in any case where the practice in
the Relevant Interbank Market differs, in accordance with that market practice.  
	 
	
39.	
PARTIAL INVALIDITY      
	 	
If, at any time, any provision of the Finance Documents is or becomes illegal, invalid or unenforceable in any respect under any law of any jurisdiction, neither the legality, validity or enforceability of the remaining
provisions nor the legality, validity or enforceability of such provision under the law of any other jurisdiction will in any way be affected or impaired.       

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40.	
REMEDIES AND WAIVERS    
	 	 
	 	
No failure to exercise, nor any delay in exercising, on the part of any Finance Party, any right or remedy under the Finance Documents shall operate as a waiver, nor shall any single or partial exercise of any right or
remedy prevent any further or other exercise or the exercise of any other right or remedy. The rights and remedies provided in this Agreement are cumulative and not exclusive of any rights or remedies provided by law.        
	 
	
41.	
AMENDMENTS AND WAIVERS  
	 
	
41.1	
Required consents       
	 	
41.1.1	
Subject to Clause 41.2 (Exceptions) any term of the Finance Documents may be amended or waived only with the consent of the Majority Lenders and the
Obligors and any such amendment or waiver will be binding on all Parties.        
	 
	 	
41.1.2	
The Facility Agent may effect, on behalf of any Finance Party, any amendment or waiver permitted by this Clause.       
	 
	
41.2	
Exceptions      
	 	
41.2.1	
An amendment or waiver that has the effect of changing or which relates to:    
	 
	 	 	
(a)	
the definition of "Majority Lenders" in Clause 1.1 (Definitions);     
	 
	 	 	
(b)	
an extension to the date of payment of any amount under the Finance Documents; 
	 
	 	 	
(c)	
a reduction in the Margin or a reduction in the amount of any payment of principal, interest, fees or commission payable;      
	 
	 	 	
(d)	
an increase in or an extension of any Commitment;      
	 
	 	 	
(e)	
a change to the Borrowers or Guarantors other than in accordance with Clause 31 (Changes to the Obligors);    
	 
	 	 	
(f)	
any provision which expressly requires the consent of all the Lenders; or      
	 
	 	 	
(g)	
Clause 2.4 (Finance Parties' rights and obligations), Clause 30 (Changes to the Lenders) or this Clause 41,        
	 
	 	 	shall not be made without the prior consent of all the Lenders.        
	 
	 	
41.2.2	
An amendment or waiver which relates to the rights or obligations of an Agent or the Arranger may not be effected without the consent of that Agent or the Arranger.   
	 
	
41.3	
Replacement of Lender   
	 	
41.3.1	
If at any time any Lender becomes a Non-Consenting Lender (as defined in sub- clause 41.3.3 below), then the Company may, on five Business Days' prior written notice to the Agent and such Lender:    
	 
	 	 	
(a)	
cancel the Commitment of the Non-Consenting Lender at the next interest payment or rollover date; or   

- 99 -

	 	 	
(b)	
require such Lender to (and such Lender shall) transfer pursuant to Clause 30 (Changes to the Lenders) all (and not part only) of its rights and
obligations under this Agreement to another Lender (a "Replacement Lender") which confirms its willingness to assume and does assume all the obligations of the transferring
Lender (including the assumption of the transferring Lender's participations on the same basis as the transferring Lender) for a purchase price in cash payable at the time of transfer equal to the outstanding principal amount of such Lender's
participation in the outstanding Utilisations and all accrued interest and/or Letter of Credit fees, Break Costs and other amounts payable in relation thereto under the Finance Documents.      
	 
	 	
41.3.2	
The replacement of a Lender pursuant to this Clause shall be subject to the following conditions:      
	 
	 	 	
(a)	
the Company shall have no right to replace the Agent;  
	 
	 	 	
(b)	
neither the Agent nor the Lender shall have any obligation to the Company to find a Replacement Lender;        
	 
	 	 	
(c)	
in the event of a replacement of a Non-Consenting Lender such replacement must take place no later than 10 Business days after the date the Non- Consenting Lender notifies the Company and the Agent of its failure or refusal
to agree to any consent, waiver or amendment to the Finance Documents requested by the Company; and      
	 
	 	 	
(d)	
in no event shall the Lender replaced under this Clause 41.3 be required to pay or surrender to such Replacement Lender any of the fees received by such Lender pursuant to the Finance Documents.     
	 
	 	
41.3.3	
In the event that:     
	 
	 	 	
(a)	
the Parent or the Agent (at the request of the Company) has requested the Lenders to consent to a waiver or amendment of any provisions of the Finance Documents;      
	 
	 	 	
(b)	
the waiver or amendment in question requires the consent of all the Lenders; and       
	 
	 	 	
(c)	
Lenders whose Commitments aggregate 85 per cent. or more of the Total Commitments (or, if the Total Commitments have been reduced to zero, aggregated 85 per cent. or more of the Total Commitments prior to that reduction)
have consented to such waiver or amendment,      
	 
	 	 	
then any Lender who has declined or failed to consent or provide approval by the later of (i) the date nominated by the Facility Agent in the request to the Lenders as a deadline for response, and (ii) 3 Business Days after
such 85 per cent. Lender approval or consent has been received, shall be deemed a "Non-Consenting Lender".      

- 100 -

	
42.	
COUNTERPARTS    
	 
	 	
Each Finance Document may be executed in any number of counterparts, and this has the same effect as if the signatures on the counterparts were on a single copy of the Finance Document.      

- 101 -

SECTION 12

GOVERNING LAW AND ENFORCEMENT

	
43.	
GOVERNING LAW   
	 
	 	
This Agreement is governed by English law.     
	 
	
44.	
ENFORCEMENT     
	 
	
44.1	
Jurisdiction    
	 	
44.1.1	
The courts of England have non-exclusive jurisdiction to settle any dispute arising out of or in connection with this Agreement (including a dispute regarding the existence, validity or termination of this Agreement) (a
"Dispute").     
	 
	 	
44.1.2	
The Parties agree that the courts of England are the most appropriate and convenient courts to settle Disputes and accordingly no Party will argue to the contrary.    
	 
	
44.2	
Service of process      
	 	
Without prejudice to any other mode of service allowed under any relevant law, each Obligor (other than an Obligor incorporated in England and Wales): 
	 
	 	
44.2.1	
irrevocably appoints the Company as its agent for service of process in relation to any proceedings before the English courts in connection with any Finance Document; and     
	 
	 	
44.2.2	
agrees that failure by an agent for service of process to notify the relevant Obligor of the process will not invalidate the proceedings concerned.    
	 
	
44.3	
Waiver of jury trial    
	 	
Each of the parties to this Agreement irrevocably waives
trial by jury in any action or proceeding with respect to this Agreement or any of the Finance Documents.

This Agreement has been entered into on the date stated at the beginning of this Agreement.

- 102 -

 

  	 	 	SCHEDULE 1

        THE ORIGINAL PARTIES

        

        Part I

        The Original Obligors	 	 
	 	 	 	 	 
	
      Name of Original Borrower 	       	
      Registration number (or   	       	
      Country / state of        
	    	       	
      equivalent, if any)       	       	
      incorporation     
	 	 	 	 	 
	
      Shire plc        	       	
      05492592 	       	
      England  
	 	 	 	 	 
	     	 	 	 	 
	
      Name of Original Guarantor        	       	
      Registration number (or   	       	
      Country / state of        
	    	       	
      equivalent, if any)       	       	
      incorporation     
	
      Shire plc        	       	
      05492592 	       	
      England  

  

- 103 -

 

  	Part II

        The Original Term Lenders
	 	 	 	 	 	 	 
	
      Name of Original Term     	        	
      Facility A        	        	
      Facility B        	        	Facility Office 
	
      Lender    	        	
      Commitment        	        	
      Commitment        	        	  
	     	 	 	 	 	 	 
	
      ABN AMRO Bank N.V.       	       	
      US$ 250,000,000      	        	
      US$ 75,000,000       	       	
      250 Bishopsgate, 
	    	       	  	        	  	       	
      London EC2M
	    	       	  	        	  	       	
      4AA      
	     	 	 	 	 	 	 
	
      Barclays Bank PLC        	       	
      US$ 250,000,000      	        	
      US$ 75,000,000       	       	
      5        The
      North 
	    	       	  	        	  	       	
      Colonnade, Canary        
	    	       	  	        	  	       	
      Wharf, London 
	    	       	  	        	  	       	
      E14 4BB  
	     	 	 	 	 	 	 
	
      Citibank, N.A., London   	       	
      US$ 250,000,000      	        	
      US$ 75,000,000       	       	
      Citigroup Centre, 
	    	       	  	        	  	       	
      25 Canada Square,        
	    	       	  	        	  	       	
      Canary Wharf, 
	    	       	  	        	  	       	
      London E14 5LB   
	     	 	 	 	 	 	 
	
      The Royal Bank of Scotland       	       	
      US$ 250,000,000      	        	
      US$ 75,000,000       	       	
      135 Bishopsgate  
	
      plc      	       	  	        	  	       	
      London   
	    	       	  	        	  	       	
      EC2M 3UR 

  

- 104 -

 

  	 	 	Part III

        The Original Revolving Lenders	 	 
	 	 	 	 	 
	
      Name of Original Revolving        	        	
      Revolving 	        	
      Facility Office   
	
      Lender    	        	Commitment 	        	  
	 	 	 	 	 
	
      ABN AMRO Bank N.V.       	       	
      US$250,000,000       	       	
      250 Bishopsgate, London EC2M     
	    	       	  	       	
      4AA      
	         	 	 	 	 
	
      Barclays Bank PLC        	       	
      US$250,000,000       	       	
      5 The North Colonnade, Canary    
	    	       	  	       	
      Wharf, London E14 4BB    
	         	 	 	 	 
	
      Citibank, N.A., London   	       	
      US$250,000,000       	       	
      Citigroup Centre, 25 Canada      
	    	       	  	       	
      Square, Canary Wharf, London     
	    	       	  	       	
      E14 5LB  
	         	 	 	 	 
	
      The Royal Bank of Scotland plc   	       	
      US$250,000,000       	       	
      135 Bishopsgate  
	    	       	  	       	
      London   
	    	       	  	       	
      EC2M 3UR 

  

- 105 -

 

  	 	 	Part IV

        The Original Dollar Swingline Lenders	 	 
	 	 	 	 	 
	
      Name of Original Dollar   	       	
      Swingline Commitment      	       	
                     Facility Office    
	
      Swingline Lender  	       	  	       	    
	     	 	 	 	 
	
      ABN AMRO Bank N.V.       	       	
      US$ 62,500,000       	       	
      540 West Madison Street, 
	    	       	  	       	
      Suite 2621 Chicago, IL   
	    	       	  	       	
      60661    
	     	 	 	 	 
	
      Barclays Bank PLC        	       	
      US$ 62,500,000       	       	
      c/o Barclays Group Inc., 
	    	       	  	       	
      Client Services Unit as US       
	    	       	  	       	
      Dollar Funding   
	    	       	  	       	
      Administrator, 11th Floor,  
	    	       	  	       	
      222 Broadway, New York,  
	    	       	  	       	
      NY 10038 USA     
	     	 	 	 	 
	
      Citicorp USA, Inc.       	       	
      US$ 62,500,000       	       	
      2 Penns Way      
	    	       	  	       	
      New Castle DE. 19720     
	    	       	  	       	
      USA      
	     	 	 	 	 
	
      The Royal Bank of Scotland plc   	       	
      US$ 62,500,000       	       	
      101 Park Avenue  
	    	       	  	       	
      12th Floor  
	    	       	  	       	
      New York, NY     
	    	       	  	       	
      10178    

  

- 106 -

 

  	 	 	Part V

        The Original Euro Swingline Lenders	 	 
	 	 	 	 	 
	
      Name of Original Euro     	        	
      Swingline Commitment      	        	
      Facility Office   
	
      Swingline Lender  	       	  	       	    
	     	 	 	 	 
	
      ABN AMRO Bank N.V.       	       	
               US$62,500,000      	       	
      250 Bishopsgate, London  
	    	       	  	       	
      EC2M 4AA 
	     	 	 	 	 
	
      Barclays Bank PLC        	       	
               US$62,500,000      	       	
      5 The North Colonnade,   
	    	       	  	       	
      Canary Wharf, London E14 
	    	       	  	       	
      4BB      
	     	 	 	 	 
	
      Citibank, N.A., London   	       	
               US$62,500,000      	       	
      Citigroup Centre, 25 Canada      
	    	       	  	       	
      Square, Canary Wharf,    
	    	       	  	       	
      London E14 5LB   
	     	 	 	 	 
	
      The Royal Bank of Scotland plc   	       	
               US$62,500,000      	       	
      135 Bishopsgate, 
	    	       	  	       	
      London   
	    	       	  	       	
      EC2M 3UR 

  

- 107 -

SCHEDULE 2

CONDITIONS PRECEDENT

Part I

Conditions precedent to initial Utilisation

	
1.	
Original Obligors       
	 
	 	
(a)	
A copy of the constitutional documents of each Original Obligor.       
	 
	 	
(b)	
A copy of a good standing certificate (including verification of tax status) with respect to each U.S. Obligor, issued as of a recent date by the Secretary of State or other appropriate official of each U.S. Obligor's
jurisdiction of incorporation or organisation.   
	 
	 	
(c)	
A copy of a resolution of the board of directors (or a duly appointed committee of the board of directors) of each Original Obligor:   
	 
	 	 	
(i)	
approving the terms of, and the transactions contemplated by, the Finance Documents to which it is a party and resolving that it execute the Finance Documents to which it is a party; 
	 
	 	 	
(ii)	
authorising a specified person or persons to execute the Finance Documents to which it is a party on its behalf; and   
	 
	 	 	
(iii)	
authorising a specified person or persons, on its behalf, to sign and/or despatch all documents and notices (including, if relevant, any Utilisation Request) to be signed and/or despatched by it under or in connection with
the Finance Documents to which it is a party.    
	 
	 	
(d)	
An extract from a resolution of the board of directors of each Original Obligor evidencing due appointment of the committee of the board of directors referred to in paragraph (c) above.      
	 
	 	
(e)	
A specimen of the signature of each person authorised by the resolution referred to in paragraph (c) above.    
	 
	 	
(f)	
A certificate of the Company (signed by a director or other authorised signatory) confirming that borrowing or guaranteeing, as appropriate, the Total Revolving Facility Commitments would not cause any borrowing,
guaranteeing or similar limit binding on any Original Obligor to be exceeded.    
	 
	 	
(g)	
A certificate of an authorised signatory of the relevant Original Obligor certifying that each copy document relating to it specified in this Part I of Schedule 2 (Conditions
precedent) is correct, complete and in full force and effect as at a date no earlier than the date of this Agreement.       

- 108 -

	
2.	
Legal opinions  
	 
	 	
(a)	
A legal opinion of Clifford Chance LLP legal advisers to the Arrangers and the Agents in England.      
	 
	 	
(b)	
If an Original Obligor is incorporated in a jurisdiction other than England and Wales, a legal opinion of the legal advisers to the Arrangers and Agents or the Company, as the case may be, in the relevant
jurisdiction.    
	 
	
3.	
Other documents and evidence    
	 
	 	
(a)	
Duly executed Fee Letters, this Agreement and the Mandate Letter.      
	 
	 	
(b)	
Evidence that any agent for service of process referred to in Clause 44.2 (Service of process), if not an Original Obligor, has accepted its
appointment.     
	 
	 	
(c)	
The Original Financial Statements and interim financial statements of the Company.     
	 
	 	
(d)	
Evidence that the fees, costs and expenses then due from the Company pursuant to Clause 18 (Fees) and Clause 23 (Costs and expenses) have been paid or will be paid by the first Utilisation Date.      
	 
	 	
(e)	
Any information that is requested by a Finance Party (acting reasonably) to ensure compliance with applicable "Know Your Customer" requirements.       
	 
	 	
(f)	
Evidence of cancellation of the facilities under the 2005 Agreement.   
	 
	 	
(g)	
A copy of any other Authorisation or other document, opinion or assurance which the Facility Agent considers to be reasonably necessary or desirable (if it has notified the Company accordingly) in connection with the entry
into and performance of the transactions contemplated by any Finance Document or for the validity and enforceability of any Finance Document.    

- 109 -

Part II

Conditions precedent to Certain Funds Utilisation

	
1.	
Evidence that the Acceptance Date (as defined in the Acquisition Agreement) has occurred or will occur on or immediately after the first Certain Funds Utilisation.    
	 
	
2.	
In relation to the Acquisition, projections from the combined Group financial model substantially in the form already distributed.     
	 
	
3.	
A copy of the Acquisition Documents, including a post Acquisition group structure chart and a sources and uses statement in a form and substance satisfactory to the Arrangers, acting reasonably.     
	 
	
4.	
A copy of the shareholder circular to be sent by the Company to its shareholders (including to the extent that the Acquisition is a Class 1 Acquisition (as defined in the Listing Rules of the Financial Services Authority),
a copy of a resolution of the shareholders of the Company approving the terms of the Acquisition, a shareholders working capital statement issued for the purposes of the Acquisition, and a copy of the working capital report) and a copy of the press
release announcing that the Company's shareholders have passed the resolution(s) set out in such shareholder circular.   
	 
	
5.	
An executed copy of the Tender and Support Agreement.  
	 
	
6.	
An executed copy of the certificate from New River in respect of conditions 2(c), (d) and (e) as described in Annex 1 of the Acquisition Agreement.    
	 
	
7.	
A certificate of the Company (signed by a director or other authorised signatory) confirming that borrowing or guaranteeing, as appropriate, the Total Commitments would not cause any borrowing, guaranteeing or similar limit
binding on any Original Obligor to be exceeded.  
	 
	
8.	
Evidence that the Company has completed a rights issue or other equity issuance in an amount sufficient to raise gross proceeds of not less than £415,000,000.    

- 110 -

Part III

Conditions precedent required to be

delivered by an Additional Obligor

	
1.	
An Accession Letter, duly executed by the Additional Obligor and the Company.  
	 
	
2.	
A copy of the constitutional documents of the Additional Obligor.      
	 
	
3.	
A copy of a good standing certificate (including verification of tax status) with respect to each U.S. Obligor, issued as of a recent date by the Secretary of State or other appropriate official of each U.S. Obligor's
jurisdiction of incorporation or organisation.   
	 
	
4.	
A copy of a resolution of the board of directors (or a duly appointed committee of the board of directors) of the Additional Obligor:  
	 
	 	
(a)	
approving the terms of, and the transactions contemplated by, the Accession Letter and the Finance Documents and resolving that it execute the Accession Letter;       
	 
	 	
(b)	
authorising a specified person or persons to execute the Accession Letter on its behalf; and   
	 
	 	
(c)	
authorising a specified person or persons, on its behalf, to sign and/or despatch all other documents and notices (including, in relation to an Additional Borrower, any Utilisation Request) to be signed and/or despatched by
it under or in connection with the Finance Documents.    
	 
	
5.	
A specimen of the signature of each person authorised by the resolution referred to in paragraph 4 above.      
	 
	
6.	
A certificate of the Additional Obligor (signed by a director or other authorised signatory) confirming that borrowing or guaranteeing, as appropriate, the Total Commitments would not cause any borrowing, guaranteeing or
similar limit binding on it to be exceeded.      
	 
	
7.	
A certificate of an authorised signatory of the Additional Obligor certifying that each copy document listed in this Part III of Schedule 2 (Conditions precedent) is correct, complete and in full force and effect as at a date no earlier than the date of the Accession Letter.  
	 
	
8.	
A copy of any other Authorisation or other document, opinion or assurance which the Facility Agent considers to be reasonably necessary or desirable in connection with the entry into and performance of the transactions
contemplated by the Accession Letter or for the validity and enforceability of any Finance Document.     
	 
	
9.	
If available, the latest audited financial statements of the Additional Obligor.       
	 
	
10.	
A legal opinion of Clifford Chance LLP, legal advisers to the Arrangers and the Agents in England.     

- 111 -

	
11.	
If the Additional Obligor is incorporated in a jurisdiction other than England and Wales, a legal opinion of the legal advisers to the Arrangers and the Agents or the Company, as the case may be, in the jurisdiction in
which the Additional Obligor is incorporated.    
	 
	
12.	
If the proposed Additional Obligor is incorporated in a jurisdiction other than England and Wales, evidence that the agent for service of process specified in Clause 44.2 (Service of
process), if not an Obligor, has accepted its appointment in relation to the proposed Additional Obligor.   

- 112 -

SCHEDULE 3

REQUESTS

Part I

Utilisation Request - Term Loans and Revolving Loan

From: [Borrower]

To: [Facility Agent]

Dated:

Dear Sirs

Shire plc – US$ 2,300,000,000 Multi-Currency Term and Revolving Facilities Agreement dated 

20 February 2007 (the "Agreement")

	
1.	
We refer to the Agreement. This is a Utilisation Request. Terms defined in the Agreement have the same meaning in this Utilisation Request unless given a different meaning in this Utilisation Request.       
	 
	
2.	
We wish to borrow a Loan on the following terms:       
	 

	 	Proposed Utilisation Date:	[          ] (or,
        if that is not a Business Day, the next Business Day)
	 	 	 
	 	Facility to be utilised:	[Facility A]/[Facility B]*/Revolving
    Facility*
	 	 	 
	 	Currency of Loan:	[          ] or, if less, the Available Facility
	 	 	 
	 	Amount:	[          ] 
	 	 	 
	 	Interest Period:	[          ] 

	
3.	
We confirm that each condition specified in Clause 4.3 (Further conditions precedent) is satisfied on the date of this Utilisation
Request. 
	 
	
4.	
[We confirm that the fees, costs and expenses due from the Company pursuant to Clause 18 (Fees) and Clause 23 (Costs and Expenses) have been paid, or if not, will be paid out of the Amount specified in paragraph 2 above]**        
	 
	
5.	
The proceeds of this Loan should be credited to [account].    
	 
	
6.	
This Utilisation Request is irrevocable.       

  	Yours
      faithfully, 
	 
	.........................................
	authorised
      signatory for

      [name of relevant Borrower]

  

 

 

- 113 -

 

	
*	
delete as appropriate  
	 
	
**	
To be included in the First Utilisation Request        

 

 

- 114 -

Part II

Utilisation Request - Swingline Loan

From: [Borrower]

To: [Swingline
Agent]

Dated:

Dear Sirs

Shire plc – US$ 2,300,000,000 Multi-Currency Term and Revolving Facilities Agreement dated 

20 February 2007 (the "Agreement")

	
1.	
      We refer to the Agreement. This is a Utilisation Request. Terms defined in the Agreement have the same meaning in this Utilisation Request unless given a different meaning in this Utilisation Request. 
	 
	
2.	
      We wish to borrow a Swingline Loan on the following terms:       
	 	 
	 	Proposed Utilisation Date:	[          ] (or,
      if that is not a Business Day, the next Business Day)
	 	 	 
	 	Facility to be utilised:	Swingline Facility
	 	 	 
	 	Currency of Loan:	[          ]
	 	 	 
	 	Amount:	[          ] or,
    if less, the Available Facility
	 	 	 
	 	Interest Period:	[          ]

	
3.	
We confirm that each condition specified in Clause 6.4 (Swingline Lenders' participation) is satisfied on the date of this Utilisation
Request. 
	 
	
4.	
The proceeds of this Swingline Loan should be credited to [account].  
	 
	
5.	
This Utilisation Request is irrevocable.       

  

  	Yours faithfully, 
	 
	.........................................
	authorised signatory
          for

        [name of relevant Borrower]

  

- 115 -

SCHEDULE 4

MANDATORY COST FORMULAE

	
1.	
The Mandatory Cost is an addition to the interest rate
to compensate Lenders for the cost of compliance with (a) the requirements of
the Bank of England and/or the Financial Services Authority (or, in either case,
any other  authority which replaces all or any of its functions) or (b) the
requirements of the European Central Bank. 
	 	 	 
	
2.	
On the first day of each Interest Period (or as soon as possible thereafter) the Facility Agent shall calculate, as a percentage rate, a rate (the "Additional Cost Rate") for each Lender, in accordance with the paragraphs set out below. The Mandatory Cost will be calculated by the Facility Agent as a weighted average of the Lenders' Additional Cost Rates (weighted in proportion to the
percentage participation of each Lender in the relevant Loan) and will be expressed as a percentage rate per annum.      
	 
	
3.	
The Additional Cost Rate for any Lender lending from a Facility Office in a Participating Member State will be the percentage notified by that Lender to the Facility Agent. This percentage will be certified by that Lender
in its notice to the Facility Agent to be its reasonable determination of the cost (expressed as a percentage of that Lender's participation in all Loans made from that Facility Office) of complying with the minimum reserve requirements of the
European Central Bank in respect of loans made from that Facility Office.        
	 
	
4.	
The Additional Cost Rate for any Lender lending from a Facility Office in the United Kingdom will be calculated by the Facility Agent as follows:      
	 
	 	
(a)	in relation to a sterling Loan:
	 	 	 	 
	 	 	AB+  C (B –  D)  +
        E x 0.01 	 
	 	 	
	  per cent. per annum
	 	 	100 – (A
        +   C)	 

	 	(b)	in relation to a Loan in any currency
    other than sterling:
	 	 	 	 
	 	 	E x 0.01	 
	 	 	
	 per cent. per annum
	 	 	300	 
	 	 	 
	 	Where:	 
	 	 	 
	 	A	is the percentage of Eligible Liabilities
      (assuming these to be in excess of any stated minimum) which that Lender
      is from time to time required to maintain as an interest free cash ratio
    deposit with the Bank of England to comply with cash ratio requirements.
	 	 	 
	 	B	is the percentage rate of interest
      (excluding the Margin and the Mandatory Cost and, if the Loan is an Unpaid
      Sum, the additional rate of interest specified in sub-clause 15.3.1 of
      Clause 15.3 (Default interest)) payable
    for the relevant Interest Period on the Loan.

- 116 -

	 	
C	
is the percentage (if any) of Eligible Liabilities which that Lender is required from time to time to maintain as interest bearing Special Deposits with the Bank of England.  
	 
	 	
D	
is the percentage rate per annum payable by the Bank of England to the Facility Agent on interest bearing Special Deposits.    
	 
	 	
E	
is designed to compensate Lenders for amounts payable under the Fees Rules and is calculated by the Facility Agent as being the average of the most recent rates of charge supplied by the Reference Banks to the Facility
Agent pursuant to paragraph 7 below and expressed in pounds per £1,000,000. 
	 

	
5.	
For the purposes of this Schedule:     
	 
	 	
(a)	
"Eligible Liabilities" and "Special Deposits" have the meanings given to them
from time to time under or pursuant to the Bank of England Act 1998 or (as may be appropriate) by the Bank of England;   
	 
	 	
(b)	
"Fees Rules" means the rules on periodic fees contained in the FSA Supervision Manual or such other law or regulation as may be in force from time to
time in respect of the payment of fees for the acceptance of deposits;   
	 
	 	
(c)	
"Fee Tariffs" means the fee tariffs specified in the Fees Rules under the activity group A.1 Deposit acceptors (ignoring any minimum fee or zero rated
fee required pursuant to the Fees Rules but taking into account any applicable discount rate); and       
	 
	 	
(d)	
"Tariff Base" has the meaning given to it in, and will be calculated in accordance with, the Fees Rules.      
	 
	
6.	
In application of the above formulae, A, B, C and D will be included in the formulae as percentages (i.e. 5 per cent. will be included in the formula as 5 and not as 0.05). A negative result obtained by subtracting D from B
shall be taken as zero. The resulting figures shall be rounded to four decimal places.   
	 
	
7.	
If requested by the Facility Agent, each Reference Bank shall, as soon as practicable after publication by the Financial Services Authority, supply to the Facility Agent, the rate of charge payable by that Reference Bank to
the Financial Services Authority pursuant to the Fees Rules in respect of the relevant financial year of the Financial Services Authority (calculated for this purpose by that Reference Bank as being the average of the Fee Tariffs applicable to that
Reference Bank for that financial year) and expressed in pounds per £1,000,000 of the Tariff Base of that Reference Bank.   
	 
	
8.	
Each Lender shall supply any information required by the Facility Agent for the purpose of calculating its Additional Cost Rate. In particular, but without limitation, each Lender shall supply the following information on
or prior to the date on which it becomes a Lender:       
	 
	 	
(a)	
the jurisdiction of its Facility Office; and   
	 
	 	
(b)	
any other information that the Facility Agent may reasonably require for such purpose. 

- 117 -

	 	
Each Lender shall promptly notify the Facility Agent of any change to the information provided by it pursuant to this paragraph.       
	 
	
9.	
The percentages of each Lender for the purpose of A and C above and the rates of charge of each Reference Bank for the purpose of E above shall be determined by the Facility Agent based upon the information supplied to it
pursuant to paragraphs 7 and 8 above and on the assumption that, unless a Lender notifies the Facility Agent to the contrary, each Lender's obligations in relation to cash ratio deposits and Special Deposits are the same as those of a typical bank
from its jurisdiction of incorporation with a Facility Office in the same jurisdiction as its Facility Office.   
	 
	
10.	
The Facility Agent shall have no liability to any person if such determination results in an Additional Cost Rate which over or under compensates any Lender and shall be entitled to assume that the information provided by
any Lender or Reference Bank pursuant to paragraphs 3, 7 and 8 above is true and correct in all respects.        
	 
	
11.	
The Facility Agent shall distribute the additional amounts received as a result of the Mandatory Cost to the Lenders on the basis of the Additional Cost Rate for each Lender based on the information provided by each Lender
and each Reference Bank pursuant to paragraphs 3, 7 and 8 above. 
	 
	
12.	
Any determination by the Facility Agent pursuant to this Schedule in relation to a formula, the Mandatory Cost, an Additional Cost Rate or any amount payable to a Lender shall, in the absence of manifest error, be
conclusive and binding on all Parties.   
	 
	
13.	
The Facility Agent may from time to time, after consultation with the Company and the Lenders, determine and notify to all Parties any amendments which are required to be made to this Schedule in order to comply with any
change in law, regulation or any requirements from time to time imposed by the Bank of England, the Financial Services Authority or the European Central Bank (or, in any case, any other authority which replaces all or any of its functions), such
changes being consistent with any generally accepted conventions and market practice in the Relevant Interbank Market, and any such determination shall, in the absence of manifest or proven error, be conclusive and binding on all
Parties. 
	 

- 118 -

SCHEDULE 5

FORM OF TRANSFER CERTIFICATE

To: [        ] as Facility Agent

From: [The Existing Lender] (the "Existing Lender") and [The New Lender] (the "New Lender")

Dated:

Shire plc – US$ 2,300,000,000 Multi-Currency Revolving Facilities Agreement dated 20

February
2007 (the "Agreement")

	
1.	
We refer to the Agreement. This is a Transfer Certificate. Terms defined in the Agreement have the same meaning in this Transfer Certificate unless given a different meaning in this Transfer Certificate.    
	 	 
	
2.	
We refer to Clause 30.5 (Procedure for transfer):     
	 	 

	 	
(a)	
The Existing Lender and the New Lender agree to the Existing Lender transferring to the New Lender by novation all or part of the Existing Lender's Commitment, rights and obligations referred to in the Schedule in
accordance with Clause 30.5 (Procedure for transfer).   
	 	 	 
	 	
(b)	
The proposed Transfer Date is [        ].   
	 	 	 
	 	
(c)	
The Facility Office and address, fax number and attention details for notices of the New Lender for the purposes of Clause 37.2 (Addresses) are set
out in the Schedule.     
	 	 	 

	
3.	
The New Lender expressly acknowledges the limitations on the Existing Lender's obligations set out in sub-clause 30.4.3 of Clause 30.4 (Limitation of responsibility of Existing
Lenders).   
	 	 
	
4.	
The New Lender confirms that [it is a Qualifying Lender] [it is not a Qualifying Lender].1 
	 	 
	
5.	
This Transfer Certificate may be executed in any number of counterparts and this has the same effect as if the signatures on the counterparts were on a single copy of this Transfer Certificate.      
	 	 
	
6.	
This Transfer Certificate is governed by English law.  

THE SCHEDULE

Commitment/rights and obligations to be transferred

[insert relevant details]

[Facility Office address, fax number and attention details for notices and account details for payments,]

1 Delete as applicable

- 119 -

	
[Existing Lender]
        	
[New Lender]
        
	
By:
        	
By:
        

This Transfer Certificate is accepted by the Facility Agent and the Transfer Date is confirmed as [ ].

[Facility Agent]

By:

- 120 -

SCHEDULE 6

FORM OF ACCESSION LETTER

To:[ ] as Facility Agent

From:[Subsidiary] and [Company] 

Dated: 

Dear Sirs

Shire plc – US$ 2,300,000,000 Multi-Currency and Term Revolving Facilities Agreement dated 

20 February 2007 (the "Agreement")

	
1.	
We refer to the Agreement. This is an Accession Letter. Terms defined in the Agreement have the same meaning in this Accession Letter unless given a different meaning in this Accession Letter.       
	 	 
	
2.	
[Subsidiary] agrees to become an Additional [Borrower]/[Guarantor] and to be bound by the terms of the Agreement as an Additional
[Borrower]/[Guarantor] pursuant to Clause [31.2 (Additional Borrowers)]/[Clause 31.4 (Additional Guarantors)] of the Agreement.        
	 	
[Subsidiary] is a company duly incorporated under the laws of [name of relevant jurisdiction].   
	 	 
	
3.	
[Subsidiary's] administrative details are as follows: 
	 	 
	 	
Address:       
	 	 
	 	
Fax No:        
	 	 
	 	
Attention:     
	 	 
	
4.	
This Accession Letter is governed by English law.      
	 	 
	 	
[This Guarantor Accession Letter is entered into by a deed.]   
	 	 
	 	
[Company]                                     [Subsidiary]/[New
Holdco]     
	 	 

- 121 -

SCHEDULE 7

FORM OF RESIGNATION LETTER

To: [                 ]
as Facility Agent

From: [resigning
Obligor] and [Company]

Dated:

Dear Sirs

Shire plc – US$ 2,300,000,000 Multi-Currency Term and Revolving Facilities Agreement dated 20 

February 2007 (the "Agreement")

	
1.	
We refer to the Agreement. This is a Resignation Letter. Terms defined in the Agreement have the same meaning in this Resignation Letter unless given a different meaning in this Resignation Letter.  
	 	 
	
2.	
Pursuant to [Clause 31.3 (Resignation of a Borrower)]/[Clause 31.6 (Resignation of a Guarantor)], we request that [resigning Obligor] be released from its obligations as a [Borrower]/[Guarantor] under the Agreement.   
	 	 
	
3.	
We confirm that:       
	 	 
	 	
(a)     
no default is continuing or would result from the acceptance of this request; and      
	 	 
	 	
(b)     
[         ]
	 	 
	
4.              	
This Resignation Letter is governed by English law.    
	 	 

	 	
[Company]
        	 
        	
[Subsidiary]
        
	 	
By:
        	 
        	
By:
        

- 122 -

SCHEDULE 8

FORM OF COMPLIANCE CERTIFICATE

To:  [                 ] as
Facility Agent 

From: [Company] 

Dated: 

Dear Sirs

Shire plc – US$ 2,300,000,000 Multi-Currency Term and Revolving Facilities Agreement dated 20

February
2007 (the "Agreement")

	
1.	
We refer to the Agreement. This is a Compliance Certificate. Terms defined in the Agreement have the same meaning when used in this Compliance Certificate unless given a different meaning in this Compliance
Certificate.     
	 	 
	
2.	
We confirm that:       
	 	 
	 	
[insert details of financial covenants and whether the Borrower is in compliance with those covenants]        
	 	 
	
3.	
[We confirm that no Default is continuing.]    
	 	 
	
4.	
We confirm that the Ratio of Net Debt to EBITDA is [•]:1, and that therefore the Facility A Margin should be [•] per cent. and the Revolving Facility Margin should be [•] per cent..   
	 	 

	
Signed:
        	 
        	

        
	
Director
        	 
        	
Director
        
	
of
        	 
        	
Of
        
	
[Company]
        	 
        	
[Company]
        

- 123 -

SCHEDULE 9

EXISTING SECURITY

	
Name of member of the 
        	 
        	
Security
        	 
        	
Total Principal Amount of
        
	
Group
        	 
        	 

        	 
        	
Indebtedness Secured
        
	
Shire LLC
        	 
        	
Money Market Fund Account
with STI Classic Funds,
collateral against equipment leases	 	
US$5,699,619
        
	 

        	 
        	 
        	 
        	 

        
	
SPG Insurance Company Ltd.
        	 
        	
Liquidity Fund account with Barclays Global Investors, collateral
against Letter of Credit issued by Barclays in favour of Zurich Insurance	 	
US$15,264,853
        
	 

        	 
        	 
        	 	 

        
	
Shire Italy S.p.A.
        	 
        	
Deposit Collateral for car leasing arrangement         	 	
EUR201,074
        
	 

        	 
        	 
	 
        	 

        
	
Shire Pharmaceuticals Iberia SL        	 
        	
Deposit Collateral against miscellaneous rental, lease
and other obligations	 
        	
EUR127,030
        
	 

        	 
        	 	 
        	 

        
	
Shire France S.A.
        	 
        	
Deposit Collateral against office
rent and sub-contractor obligations 	 
        	
EUR132,226
        
	 

        	 
        	 
	 
        	 

        
	
Shire Deutschland GmbH & Co. KG    	 
        	
Deposit Collateral against office
rent obligations	 
        	
EUR61,804
        
	 
        	 
        	 
        	 
        	 

        
	
Shire Holdings AG
        	 
        	
Deposit Collateral against office rent obligations	 
        	
CHF10,699
        
	 

        	 
        	 
        	 
        	 

        
	
Transkaryotic or any of its Subsidiaries
        	 
        	
Marketable Securities totalling US$7,821,790 collateral for letters of credit over
lease obligations	 	
US$7,821,790
        
	 

        	 
        	 
	 
        	 

        
	
Shire Human Genetic Therapies Srl	 
        	
Research Grant guarantee
        	 	
EUR 422,395.25
        

- 124 -

SCHEDULE 10

EXISTING LOANS

	
Name of member of the
        	 
        	
                              Loan
        	 
        	
Total Principal Amount of
        
	
Group
        	 
        	 

        	 
        	
Existing Loans
        
	
Shire LLC
        	 
        	
Loan Facility between Shire
        	 
        	
US$43,103,041
        
	 

        	 
        	
LLC and ID Biomedical
        	 
        	 

        
	 

        	 
        	
Corporation
        	 
        	 

        

- 125 -

SCHEDULE 11

EXISTING FINANCIAL INDEBTEDNESS

	
Name of member of the
        	 
        	
Financial Indebtedness  	 
        	
Total Principal Amount of
        
	
Group
        	 
        	 

        	 
        	
Existing Financial
        
	 

        	 
        	 

        	 
        	
Indebtedness
        
	
Shire Pharmaceuticals Inc.
        	 
        	
Counter Indemnity from Shire
Pharmaceuticals Inc. to PNC Bank,
NA for US$68,824 Stand-by Letter of
Credit ref: 18101044-00-000 in favour
of Tredyffrin Township  	 
        	
US$6,257
        
	 

        	 
        	 	 
        	 

        
	
SPG Insurance Company Ltd.
        	 
        	
Liquidity Fund account with
Barclays Global Investors, collateral
against Letter of Credit issued by Barclays
in favour of Zurich Insurance   	 
        	
US$15,264,853
        
	 

        	 
        	 	 
        	 

        
	
Transkaryotic or any of its
Subsidiaries   	 
        	
Marketable Securities totalling
US$7,821,790 collateral for letters
of credit over lease obligations  	 
        	
US$7,821,790
        
	 	 	 	 	 
	
New River
        	 
        	
US$137,750,000 3.50% Convertible
Notes due 2013   	 
        	
US$137,750,000
        

- 126 -

SCHEDULE 12

FORM OF CONFIDENTIALITY UNDERTAKING

CONFIDENTIALITY AGREEMENT

 

	DATED:	 2007

PARTIES:

	(1)	[ ] ("Discloser");
    and
	 	 
	(2)	[ ] ("Recipient").

RECITALS

The Discloser is willing to disclose to the Recipient and the Recipient wishes to receive certain Confidential Information (as defined below) for the Purpose (as defined below) on the terms and conditions set out in this
Agreement.

OPERATIVE PROVISIONS

	1.	DEFINITIONS	 	 
	 	 	 	 
	1.1	In this Agreement:	 	 
	 	 	 	 
	 	Affiliates

        	 
        	means any company or other entity which directly or indirectly controls, is controlled by or is under common control with a Party, where ‘control’ means the ownership of more than 50
per cent. of the issued share capital or other equity interest or the legal power to direct or cause the direction of the general management and policies of such Party, company or other entity;

        
	 	 	 	 
	 	Confidential Information

        	 
        	means all information, data and any other material relating to Shire’s and its Affiliates’ business, projects or products, being information:

        

	 	
(i)	
disclosed by the Discloser or its Representatives to the Recipient or its Representatives or acquired directly or indirectly from the Discloser or its Representatives by the Recipient or its Representatives in each case for
the purposes of or in connection with the Purpose and whether in written, electronic, oral, visual or other form;        
	 	 	 
	 	
(ii)	
generated by way of any analysis, compilations, data studies or other documents prepared by the Recipient or its Representatives containing,   

- 127 -

	 	 	
reflecting or based in whole or in part on information referred to in (i) above; and   
	 	 	 
	 	
(iii)	
regarding the existence, nature or status of any discussions between the Parties or their Representatives with respect to the Purpose, including the existence and terms of this Agreement;    
	 	 	 
	 	 Confidential Information shall not include
    information, data and any other material that:

	 	 	 

	 	
(a)	
is public knowledge at the time of disclosure under this Agreement or which subsequently becomes public knowledge (other than as a result of a breach of this Agreement or other fault on the part of the Recipient or its
Representatives); or     
	 	 	 
	 	
(b)	
was lawfully in the possession of the Recipient or its Representatives prior to its disclosure under this Agreement or which subsequently comes into its or their possession from a third party (to the best of its or their
knowledge having made due enquiry, otherwise than in breach of any obligation of confidentiality owed to the Discloser or its Representatives, either directly or indirectly);   
	 	 	 

	Party and Parties

        	 
        	means respectively the Discloser or the Recipient or, as the case may be, both such parties;

        
	 	 	 
	Purpose

        	 
        	means the use of the Confidential Information to allow [the Parties to discuss the possibility of the Recipient acquiring] / [the Recipient to acquire]2
an interest in a financial facility to Shire;

        
	 	 	 
	Representatives

        	 
        	means the Affiliates of each Party and the directors, officers, employees, agents, representatives, attorneys and advisors of each Party and each Party’s Affiliates; and

        

	Shire

        	 	 means Shire plc, a company
              incorporated in England and Wales registered number 05492592, whose
              registered office is at Hampshire International Business Park, Chineham,
              Basingstoke, Hampshire RG24 8ED.

        

2 Delete as appropriate

- 128 -

	
1.2	
In this Agreement, unless the context otherwise requires:      
	 	 

	 	
1.2.1	
references to "persons" includes individuals, bodies corporate (wherever incorporated), unincorporated associations and partnerships;  
	 	 	 
	 	
1.2.2	
the headings are inserted for convenience only and do not affect the construction of the Agreement;    
	 	 	 
	 	
1.2.3	
references to one gender includes both genders; and    
	 	 	 
	 	
1.2.4	
a "Party" includes references to that party’s successors and permitted assigns.   
	 	 	 

	
2.	
USE AND NON-DISCLOSURE      
	 	 
	
2.1	
Subject to the terms of this Agreement, in consideration of the disclosure of the Confidential Information by or on behalf of the Discloser to the Recipient or its Representatives, the Recipient undertakes: 
	 	 

	 	
2.1.1	
not to use the Confidential Information nor allow it to be used by its Representatives for any purpose other than the Purpose and to cease to use it upon request by the Discloser;    
	 	 	 
	 	
2.1.2	
to treat and maintain the Confidential Information in strict confidence and not to directly or indirectly communicate or disclose it in any way to any other person without the Discloser’s express prior written consent,
except to such of the Recipient’s Representatives who reasonably require access to the Confidential Information for the Purpose and who are notified of the terms of this Agreement and who owe a duty of confidence to the Recipient in respect the
Confidential Information;        
	 	 	 
	 	
2.1.3	
to assume responsibility and liability for any breach of the terms of this Agreement by any of the Recipient’s Representatives (or actions which would amount to such a breach if the same were party to this Agreement)
who have access to the Confidential Information; and     
	 	 	 
	 	
2.1.4	
to take all reasonable measures and appropriate safeguards commensurate with those which the Recipient employs for the protection of its confidential information (and to procure that all such steps are taken by its
Representatives) to maintain the confidentiality of the Confidential Information, to copy the Confidential Information only to the extent reasonably necessary to achieve the Purpose and not to permit unsupervised copying of the Confidential
Information.     
	 	 	 

	
2.2	
No disclosure or announcement to any third party of the Confidential Information may be made by the Recipient or on its behalf except where:   
	 	 

	 	
2.2.1	
such disclosure is compelled by a court of law, statute, regulation or securities exchange;    

- 129 -

	 	
2.2.2	
the Discloser has, where practicable, been given sufficient written notice in advance to enable it to seek protection or confidential treatment of such Confidential Information; and  
	 	 	 
	 	
2.2.3	
such disclosure is limited to the extent actually so required. 
	 	 	 

	
3.	
RIGHTS TO CONFIDENTIAL INFORMATION      
	 	 
	
3.1	
The Recipient acknowledges that nothing in this Agreement is intended to amount to or implies any transfer, licence or other grant of rights in relation to the Confidential Information or any other patents, design right,
trade marks, copyright or other intellectual property rights owned or used by the Discloser.     
	 	 
	
3.2	
The Discloser and its Representatives give no warranty
as to the completeness, sufficiency or accuracy of the Confidential Information
and accepts no liability howsoever arising from the Recipient’s or its
Representatives’ use of the Confidential Information. Accordingly, neither
the Discloser nor its Representatives shall be liable for any direct, indirect
or consequential loss or damage suffered by any person howsoever arising, whether
in  contract or tort, as a result of relying on any statement contained in or
omitted from the Confidential Information. For
the avoidance of doubt this clause is without prejudice to the express terms
of any agreement entered into by the Discloser and/or its Representatives in
connection with the Purpose. 
	 	 
	
3.3	
Nothing in this Agreement shall be or be construed as being an agreement between the Parties or any of their respective Affiliates to enter into any arrangement or further agreement relating to the subject matter of this
Agreement, any such arrangement or agreement being the subject of separate negotiations. 
	 	 
	
3.4	
The Recipient acknowledges and agrees that all Confidential Information and all copies thereof shall be and remain the exclusive property of the Discloser. The Recipient shall or shall procure, on the Discloser’s
request and at the Discloser’s option, either the destruction or return of the Confidential Information, without retaining any copies, extracts or other reproductions in whole or in part thereof other than to the extent required to be retained
for legal or regulatory purposes (in respect of which the Recipient shall remain under an ongoing duty of confidence). On the Discloser’s request, all Confidential Information comprising analyses, compilations, data studies or other documents
prepared by the Recipient or its Representatives containing or based in whole or in part on the Confidential Information received from the Discloser or reflecting the Recipient’s view of such Confidential Information shall be destroyed by the
Recipient save to the extent required to be retained for legal or regulatory purposes (in respect of which the Recipient shall remain under an ongoing duty of confidence). Upon request, such return and/or destruction shall be certified in writing to
the Discloser by an authorised officer of the Recipient supervising such destruction or return.  
	 	 
	
4.	
REMEDIES        
	 	 
	
4.1	
Due to the proprietary nature of the Confidential Information, the Parties understand and agree that the Discloser or its Affiliates may suffer irreparable harm in the event that the 

- 130 -

	 	
Recipient fails to comply with any of the obligations contained herein and that monetary damages alone may not be an adequate remedy to compensate the Discloser or its Affiliates for such breach. Accordingly, the Parties
agree that the Discloser or any of its Affiliates, as appropriate, shall be entitled to seek the remedies of injunction, specific performance and other equitable relief for any threatened or actual breach of the obligations contained in this
Agreement.       
	 	 
	
5.	
DURATION        
	 	 
	
5.1	
The term of this Agreement shall be for a period of three (3) years from the date of disclosure under this Agreement.  
	 	 
	
6.	
OTHER PROVISIONS        
	 	 
	
6.1	
Any variation to this Agreement is only valid if it is in writing and signed by or on behalf of each party.    
	 	 
	
6.2	
This Agreement may not be assigned by a Party without the prior written consent of the other Party.    
	 	 
	
6.3	
Any delay or failure by the Discloser in exercising any right power or privilege under this Agreement shall not constitute a waiver of such right, power or privilege nor shall any single or partial exercise preclude any
future exercise. 
	 	 
	
6.4	
The rights and remedies of each of the Parties under or pursuant to this Agreement are cumulative, may be exercised as often as such Party considers appropriate and are in addition to its rights and remedies under general
law.     
	 	 
	
6.5	
The provisions of this Agreement shall be severable in the event that any of the provisions hereof are held by a court of competent jurisdiction to be invalid, void or otherwise unenforceable, and the remaining provisions
shall remain enforceable to the fullest extent permitted by law. 
	 	 
	
6.6	
A person who is not a party to this Agreement other
than the Discloser’s Affiliate shall have no right under the Contracts (Rights
of Third Parties) Act 1999 to enforce any of its terms. Notwithstanding
the foregoing, this Agreement may be varied or terminated by agreement in writing
between the parties or this Agreement may be rescinded (in each case), without
the consent of any such Affiliates. 
	 	 
	
6.7	
This Agreement may be executed in one or more counterparts, each of which will be deemed to be an original copy of the Agreement, and all of which, when taken together, shall be deemed to constitute one and the same
agreement. Signatures to this Agreement transmitted by facsimile transmission, by electronic mail in "portable document format" (".pdf") form, or by any other electronic means intended to preserve the original graphic and pictorial appearance of a
document, will have the same effect as physical delivery of the paper document bearing the original signature.   
	 	 
	
6.8	
This Agreement shall be governed by and construed in accordance with English law and subject to the exclusive jurisdiction of the English courts.      

- 131 -

	
Signed for and on behalf of
        	 
        	
)
        	 
        	 

        
	
        	
        	
        	
        	

    
	 

        	 
        	
)
        	 
        	
Signature
        
	 

        	 
        	
)
        	 
        	 

        
	
        	
        	
        	
        	
    
	 

        	 
        	 

        	 
        	
Print Name
        
	
        	
        	
        	
        	
    
	 

        	 
        	 

        	 
        	
Print Title
        
	
Signed for and on behalf of
        	 
        	
)
        	 
        	 

        
	
        	
        	
        	
        	
    
	 

        	 
        	
)
        	 
        	
Signature
        
	 

        	 
        	
)
        	 
        	 

        
	
        	
        	
        	
        	
    
	 

        	 
        	 

        	 
        	
Print Name
        
	
        	
        	
        	
        	
    
	 

        	 
        	 

        	 
        	
Print Title
        

- 132 -

SCHEDULE 13

TIMETABLES

Revolving and Term Loans

	  	     	
Loans in euro	      	
Loans in

domestic

sterling     	      	
Loans in

dollars      	      	Loans in

other

currencies   
	
Facility Agent notifies the    	     	
-  	       	
-  	       	         	       	
U-4        
	
Company if a currency is       	     	         	       	         	       	         	       	         
	
approved as an Optional        	     	         	       	         	       	         	       	         
	
Currency in accordance with    	     	         	       	         	       	         	       	         
	
Clause 4.4 (Conditions relating        	     	         	       	         	       	         	       	         
	
to Optional Currencies)        	     	         	       	         	       	         	       	         
	 	 	 	 	 	 	 	 	 
	
Delivery of a duly completed   	     	
U-3        	       	
U      	       	
U-1        	       	
U-3        
	
Utilisation Request (Clause 5.1        	     	
2.00pm 	       	
9.30am 	       	
2.00pm 	       	
2.00pm 
	
(Delivery of a
Utilisation Request)) 	     	         	       	         	       	         	       	         
	 	     	         	       	         	       	         	       	         
	
Facility Agent determines (in  	     	
U-3        	       	
U      	       	
U-1        	       	
U-3        
	
relation to a Utilisation) the 	     	
3.30pm 	       	
10.00am        	       	
3.30pm 	       	
3.30pm 
	
Base Currency Amount of the    	     	         	       	         	       	         	       	         
	
Loan, if required under Clause 	     	         	       	         	       	         	       	         
	
5.4 (Lenders' participation)  	     	         	       	         	       	         	       	         
	 	 	 	 	 	 	 	 	 
	
Facility Agent notifies the    	     	
U-3        	       	
U      	       	
U-1        	       	
U-3        
	
Lenders of the Loan in 	     	
5.00pm 	       	
10.30am        	       	
3.30pm 	       	
5.00pm 
	
accordance with Clause 5.4     	     	         	       	         	       	         	       	         
	
(Lenders' participation)      	     	   	      	   	      	   	      	   
	 	 	 	 	 	 	 	 	 
	
LIBOR is fixed 	     	
Quotation Day  	         	
Quotation Day  	         	
Quotation Day  	         	
Quotation Day  
	  	     	
as of 11:00    	         	
as of 11:00    	         	
as of 11:00    	         	
as of 11:00    
	  	     	
a.m. London    	         	
a.m.   	         	
a.m.   	         	
a.m.   
	  	     	
time   	        	  	        	  	        	  

	
Swingline Loans
	      	     	
Loans in euro   	      	
Loans in Dollars        
	
Delivery of a duly completed   	     	
U      	      	
U      
	
Utilisation Request (Clause 6.2        	     	
10.00am        	      	
11.00am (New York time)        
	
(Delivery of a Utilisation Request for 	     	         	      	         
	
Swingline Loans))      	     	         	      	         
	 	 	 	 	 
	
Swingline Agent determines (in 	     	
U      	      	
U      
	
relation to a Utilisation) the Base    	     	         	      	         

- 133 -

	
Currency Amount of the Swingline
        	 
        	
11.00am
        	 
        	
1.00pm (New York time)
        
	
Loan, if required under Clause 6.4
        	 
        	 

        	 
        	 

        
	
(Swingline Lenders' Participation)
        	 
        	 

        	 
        	 

        
	
and notifies each Swingline Lender of
        	 
        	 

        	 
        	 

        
	
the amount of its participation in the
        	 
        	 

        	 
        	 

        
	
Swingline Loan under Clause 6.4
        	 
        	 

        	 
        	 

        
	
(Swingline Lenders Participation)
        	 
        	 

        	 
        	 

        

"U" = date of utilisation

"U - X" = X Business Days prior to date of utilisation

- 134 -

SIGNATURES

SHIRE PLC

By:

	
Address:
        	 
        	
Hampshire International Business Park
        
	 

        	 
        	
Chineham
        	 

        
	 

        	 
        	
Basingstoke
        	 

        
	 

        	 
        	
Hampshire RG24 8ED
        
	 

        	 
        	
Contact:
        	
Group Treasurer (copy to Legal Department)
        
	 

        	 
        	
Facsimile:
        	
+44 (0)1256 894713
        

The Original Borrower

SHIRE PLC

By:

	 Address: 	  	 Hampshire International
        Business Park 
	  	  	 Chineham 	  
	  	  	 Basingstoke 	  
	  	  	 Hampshire RG24 8ED 
	  	  	 Contact: 	 Group Treasurer (copy
        to Legal Department) 
	  	  	 Facsimile: 	 +44 (0)1256
          894713  

The Original Guarantor

SHIRE PLC

By:

	 Address: 	  	 Hampshire International
        Business Park 
	  	  	 Chineham 	  
	  	  	 Basingstoke 	  
	  	  	 Hampshire RG24 8ED 
	  	  	 Contact: 	 Group Treasurer (copy
        to Legal Department) 
	  	  	 Facsimile: 	 +44 (0)1256
          894713  

- 135 -

The Arrangers

ABN AMRO BANK N.V.

By:

	
Address:
        	 
        	
250 Bishopsgate        
	 
        	 	London EC2M 4AA
	 

        	 
        	
Contact:
        	
      +
      44
      (0)207
    678
    7022
        
	 

        	 
        	
Facsimile:
        	
      +
      44
      (0)207
    678
    6070
        

BARCLAYS CAPITAL

By:

	
Address:
        	 
        	
5 The North Colonnade          
	 

        	 
        	
Canary Wharf   
	 

        	 
        	
London E14 5BB         
	 

        	 
        	
Contact:
        	
      +
      44
      (0)207
      773
      2360
        
	 

        	 
        	
Facsimile:
        	
      +
      44
      (0)207
      773
      1572
        

CITIGROUP GLOBAL MARKETS LIMITED

By:

	
Address:
        	 
        	
Citigroup Centre
        
	 

        	 
        	
33 Canada Square
        
	 

        	 
        	
Canary Wharf
        
	 

        	 
        	
London E14 5LB
        
	 

        	 
        	
Contact:
        	
+44
(0)207 986 7160 
        
	 

        	 
        	
Facsimile:
        	
+44 (0)207 986 8278
        

- 136 -

THE ROYAL BANK OF SCOTLAND PLC

By:

	
Address:
        	 
        	
135 Bishopsgate        
	 
        	 	London EC2M 3UR
	 

        	 
        	
Contact:
        	
      +
      44
      (0)207
    085
    8732
        
	 

        	 
        	
Facsimile:
        	
      +
      44
      (0)207
    085
    5143
        

The Original Term Lenders

ABN AMRO BANK N.V.

By:

	
Address:
        	 
        	
250 Bishopsgate        
	 
        	 	London EC2M 4AA
	 

        	 
        	
Contact:
        	
      +
      44
      (0)207
    678
    7022
        
	 

        	 
        	
Facsimile:
        	
      +
      44
      (0)207
    678
    6070
        

BARCLAYS BANK PLC

By:

	
Address:
        	 
        	
5 The North Colonnade          
	 

        	 
        	
Canary Wharf   
	 

        	 
        	
London E14 5BB         
	 

        	 
        	
Contact:
        	
      +
      44
      (0)207
      773
      2360
        
	 

        	 
        	
Facsimile:
        	
      +
      44
      (0)207
      773
      1572
        

- 137 -

CITIBANK, N.A., LONDON

By:

	
Address:	 
        	
Citigroup Centre
	 

        	 
        	
33 Canada Square
	 

        	 
        	
Canary Wharf
	 

        	 
        	
London E14 5LB
	 

        	 
        	
Contact:	
+44
(0)207 986 2669
        
	 

        	 
        	
Facsimile:	
+44
(0)207 986 4329
        

THE ROYAL BANK OF SCOTLAND PLC

By:

	
Address:	 
        	
135 Bishopsgate
	 
	 	London EC2M 3UR
	 

        	 
        	
Contact:	
      +
      44
      (0)207
    085
    8732
	 

        	 
        	
Facsimile:	
      +
      44
      (0)207
    085
    5143

The Original Revolving Lenders

ABN AMRO BANK N.V.

By:

	
Address:	 
        	
250 Bishopsgate
	 
        	 	London EC2M 4A
	 

        	 
        	
Contact:	
      +
      44
      (0)207
    678
    7022
	 

        	 
        	
Facsimile:	
      +
      44
      (0)207
    678
    6070

- 138 -

BARCLAYS BANK PLC

By:

	 Address:	  	 5 The North Colonnade
	  	  	 Canary Wharf
	  	  	 London E14 5BB
	  	  	 Contact:	 +   44   (0)207   773   2360
	  	  	 Facsimile:	 +   44   (0)207   773   1572

CITIBANK, N.A., LONDON

By:

	
Address:	 
        	
Citigroup Centre
	 

        	 
        	
33 Canada Square
	 

        	 
        	
Canary Wharf
	 

        	 
        	
London E14 5LB
	 

        	 
        	
Contact:	
+44
(0)207 986 2669
        
	 

        	 
        	
Facsimile:	
+44
(0)207 986 4329
        

THE ROYAL BANK OF SCOTLAND PLC

By:

	
Address:	 
        	
135 Bishopsgate
	 
        	 	London EC2M 3UR
	 

        	 
        	
Contact:	
      +
      44
      (0)207
    085
    8810
	 

        	 
        	
Facsimile:	
      +
      44
      (0)207
    085
    8732

- 139 -

The Original Dollar Swingline Lenders

ABN AMRO BANK N.V.

By:

	
Address:	 
        	
250 Bishopsgate
	 
	 	London EC2M 4AA
	 

        	 
        	
Contact:	
      +
      44
      (0)207
    678
    7022
	 

        	 
        	
Facsimile:	
      +
      44
      (0)207
    678
    6070

BARCLAYS BANK PLC

By:

	
Address:	 
        	
c/o Barclays Group Inc.,
	 

        	 
        	
Client Services Unit as US Dollar Funding Administrator,
	 

        	 
        	
11th Floor,
222 Broadway,
	 

        	 
        	
New York, NY 10038 USA
	 

        	 
        	
Contact:	
      +
      44
      (0)207
      773 2360
	 

        	 
        	
Facsimile:	
      +
      44
      (0)207
      773 1572

CITICORP USA, INC.

By:

	
Address:	 
        	
2 Penns Way,
	 

        	 
        	
New Castle DE. 19720
	 

        	 
        	
USA	 
        
	 

        	 
        	
Contact:	
      + 1
    302
    894
    6109
	 

        	 
        	
Facsimile:	
      + 1
    212
    994
    0847

- 140 -

THE ROYAL BANK OF SCOTLAND PLC

By:

	
Address:	 
        	
135 Bishopsgate
	 
	 	London EC2M 3UR
	 

        	 
        	
Contact:	
      +
      44
      (0)207
    085
    8810
	 

        	 
        	
Facsimile:	
      +
      44
      (0)207
    085
    8732

The Original Euro Swingline Lenders

ABN AMRO BANK N.V.

By:

	
Address:	 
        	
250 Bishopsgate
	 
        	 	London EC2M 4AA
	 

        	 
        	
Contact:	
      +
      44
      (0)207
    678
    7022
	 

        	 
        	
Facsimile:	
      +
      44
      (0)207
    678
    6070

BARCLAYS BANK PLC

By:

	 Address:	  	 5 The North
        Colonnade
	  	  	 Canary Wharf
	  	  	 London E14
        5BB
	  	  	 Contact:	  +   44   (0)207   773   2360
	  	  	 Facsimile: 	  +   44   (0)207   773   1572

- 141 -

	
CITIBANK, N.A., LONDON
        
	 	 	 	 
	
By:	 
        	 

        	 

        
	 	 	 	 
	
Address:	 
        	
Citigroup Centre
	 

        	 
        	
33 Canada Square
	 

        	 
        	
Canary Wharf
	 

        	 
        	
London E14 5LB
	 

        	 
        	
Contact:	
+ 44
(0)207 986 2669
        
	 

        	 
        	
Facsimile:	
+44
(0)207 986 4329
        

	
THE ROYAL BANK OF SCOTLAND PLC
	 	 	 	 
	
By:	 
        	 

        	 

        
	 	 	 	 
	
Address:	 
        	
135 Bishopsgate
	 
        	 	London EC2M 3UR
	 

        	 
        	
Contact:	
+44
(0)207 085 8810
        
	 

        	 
        	
Facsimile:	
+44
(0)207 085 8732
        

	
The Facility Agent
	 	 	 	 
	
BARCLAYS BANK PLC
	 	 	 	 
	
By:	 
        	 

        	 

        
	 	 	 	 
	
Address:	 
        	
5 The North Colonnade
	 

        	 
        	
Canary Wharf
	 

        	 
        	
London E14 5BB
	 

        	 
        	
Contact:	
+44
(0)207 773 2360
        
	 

        	 
        	
Facsimile:	
+44
(0)207 773 1572
        

- 142 -

	
The Dollar Swingline Agent
	 	 	 	 
	
BARCLAYS BANK PLC
	 	 	 	 
	
By:	 
        	 

        	 

        
	 	 	 	 
	
Address:	 
        	
c/o Barclays Group Inc.,
	 

        	 
        	
Client Services Unit as US Dollar Funding Administrator,
	 

        	 
        	
11th Floor,
222 Broadway,
	 

        	 
        	
New York, NY 10038 USA
	 

        	 
        	
Contact:	
+44
(0)207 773 2360
        
	 

        	 
        	
Facsimile:	
+44
(0)207 773 1572
        
	 	 	 	 
	 	 	 	 
	
The Euro Swingline Agent
	 	 	 	 
	
BARCLAYS BANK PLC
	 	 	 	 
	
By:	 
        	 

        	 

        
	 	 	 	 
	
Address:	 
        	
5 The North Colonnade
	 

        	 
        	
Canary Wharf
	 

        	 
        	
London E14 5BB
	 

        	 
        	
Contact:	
+44
(0)207 773 2360
        
	 

        	 
        	
Facsimile:	
+44
(0)207 773 1572
        

- 143 -

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00122-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00122-of-00352.parquet"}]]