Document:

Exhibit
10.4

 

GENERAL
SECURITY AGREEMENT

 

GENERAL
SECURITY AGREEMENT dated December 20, 2019, made by Pressure BioSciences, Inc., a Massachusetts corporation (“Debtor”),
and the undersigned lender set forth on Schedule A hereto, as supplemented from time to time (collectively, the “Secured
Party”).

 

Debtor
hereby agrees in favor of Secured Party as follows:

 

1.
In consideration for loans made or to be made to Debtor evidenced by the 10% Senior Secured Convertible Promissory Note of Debtor
of even date herewith, in the principal amounts set forth on Schedule A hereto, payable to the order of Secured Party,
together with such additional promissory notes issued by Debtor to the Secured Party from time to time hereafter as supplemented
on Schedule A, including but limited to an Notes issued in exchange for other securities of the Debtor (such promissory
notes, as amended, modified, supplemented, replaced or substituted from time to time, being herein referred to as the “Notes”),
Debtor hereby grants to Secured Party a continuing security interest in, lien upon and a right of setoff against, and Debtor hereby
assigns to Secured Party, all of Debtor’s right, title and interest in and to the Collateral described in Section 2, to
secure the full and prompt payment, performance and observance of all present and future indebtedness, obligations, liabilities
and agreements of any kind of Debtor to Secured Party arising under or in connection with the Notes, which is existing now or
hereafter (all of the foregoing being herein referred to as the “Obligations”).

 

2.
The Collateral is described on Schedule B annexed hereto as part hereof and on any separate schedule(s) identified as Collateral
at any time or from time to time furnished by Debtor to Secured Party (all of which are hereby deemed part of this Security Agreement)
and includes claims of Debtor against third parties for loss or damage to or destruction of any Collateral.

 

    	 

    	 

    

 

3.
Debtor hereby warrants, represents, covenants and agrees (as of the date hereof and so long as any Obligation remains outstanding)
that: (a) the chief executive office and other places of business of Debtor, the books and records relating to the Collateral
(except for such records as are in the possession or control of Secured Party) and the Collateral are located at 14 Norfolk Avenue,
South Easton, Massachusetts 02375, and Debtor will not change any of the same, or merge or consolidate with any person or change
its name or conduct its business under any trade, assumed or fictitious name, without prior written notice to and consent of Secured
Party (and in the case of location of Collateral, will from time to time notify Secured Party of the locations thereof); (b) the
Collateral is and will be used in the business of Debtor and not for personal, family, household or farming use; (c) the Collateral
is now, and at all times will be, owned by Debtor free and clear of all liens, security interests, claims and encumbrances; (d)
Debtor will not abandon or assign, sell, lease, transfer or otherwise dispose of, other than in the ordinary course of Debtor’s
business, nor will Debtor suffer or permit any of the same to occur with respect to, any Collateral, without prior written notice
to and consent of a designated representative of the Secured Party; (e) Debtor will make payment or will provide for the payment,
when due, of all taxes, assessments or contributions or other public or private charges which have been or may be levied or assessed
against Debtor, whether with respect to the Collateral, to any wages or salaries paid by Debtor, or otherwise, will deliver to
Secured Party, on demand, certificates or other evidence satisfactory to Secured Party attesting thereto and shall cause Debtor’s
subsidiaries to take any such action as described under this section 3(e); (f) Debtor will use the Collateral for lawful purposes
only, with all reasonable care and caution and in conformity in all material respects with all applicable laws, ordinances and
regulations; (g) Debtor will, at Debtor’s sole cost and expense, keep the Collateral in good order, repair, running condition
and in substantially the same condition as on the date hereof, reasonable wear and tear excepted, and Debtor will not, without
the prior written consent of Secured Party, alter or remove any identifying symbol or number upon any of the Collateral; (h) Secured
Party shall at all times during normal business hours have free access to and right of inspection of any Collateral and any papers,
instruments and records pertaining thereto (and the right to make extracts from and to receive from Debtor originals or true copies
of such records, papers and instruments upon request therefor) and Debtor hereby grants to Secured Party a security interest in
all such records, papers and instruments to secure the payment, performance and observance of the Obligations; (i) the Collateral
is now and shall remain personal or intangible property, and Debtor will not permit any other types of Collateral to become a
fixture without prior written notice to and consent of Secured Party and without first making all arrangements, and delivering,
or causing to be delivered, to Secured Party all instruments and documents, including, without limitation, waivers and subordination
agreements by any landlords or mortgagees, requested by and satisfactory to Secured Party to preserve and protect the primary
security interest granted herein against all persons; (j) Debtor will, at its sole cost and expense, perform all acts and execute
all documents requested by Secured Party from time to time to evidence, perfect, maintain or enforce Secured Party’ first
priority security interest granted herein or otherwise in furtherance of the provisions of this Security Agreement; (k) at any
time and from time to time, Debtor shall, at its sole cost and expense, execute and deliver to Secured Party such financing statements
pursuant to the Uniform Commercial Code (“UCC”), applications for certificate of title and other papers, documents
or instruments as may reasonably be requested by Secured Party in connection with this Security Agreement, and to the extent permitted
by applicable law, Debtor hereby authorizes Secured Party to execute and file at any time and from time to time one or more financing
statements or copies thereof or of this Security Agreement with respect to the Collateral signed only by Secured Party, and Debtor
agrees to pay any recording tax or similar tax arising in connection with the filing of any such financing statement and further
agrees to pay any additional recording or similar tax which is incurred in connection therewith; (l) Debtor assumes all responsibility
and liability arising from the Collateral; (m) in their discretion, Secured Party may, at any time and from time to time, upon
the occurrence and during the continuance of a Default (as hereinafter defined), subject to the Uniform Commercial Code as in
effect in the State of New York, demand, sue for, collect or receive any money or property at any time payable or receivable on
account of or in exchange for, or make any compromise or settlement deemed desirable by Secured Party with respect to, any Collateral,
and/or extend the time of payment, arrange for payment in installments, or otherwise modify the terms of, or release, any of the
Obligations and/or the Collateral, or any obligor, maker, endorser, acceptor, surety or guarantor of, or any Party to, any of
the Obligations or the Collateral, all without notice to or consent by Debtor and without otherwise discharging or affecting the
Obligations, the Collateral or the second priority security interest granted herein; (n) in their discretion, Secured Party may,
at any time and from time to time, for the account of Debtor, pay any amount or do any act required of Debtor hereunder and which
Debtor fails to do or pay, and any such payment shall be deemed an advance by Secured Party to Debtor payable on demand together
with interest at the highest rate then payable on any of the Obligations; (o) Debtor will promptly pay Secured Party for any and
all reasonable sums, costs, and expenses which Secured Party may pay or incur pursuant to the provisions of this Security Agreement
or in perfecting, defending, protecting or enforcing this Security Agreement or the first priority security interest granted herein
or in enforcing payment of the Obligations or otherwise in connection with the provisions hereof, including but not limited to
all reasonable search, filing and recording fees, taxes, fees and expenses for the service and filing of papers, premium on bonds
and undertakings, fees of marshals, sheriffs, custodians, auctioneers, court costs, collection charges, travel expenses, and reasonable
attorneys’ fees, all of which together with interest at the highest rate then payable on any of the Obligations, shall be
part of the Obligations and be payable on demand; (p) upon the occurrence and during the continuance of a Default, any proceeds
of the Collateral received by Debtor shall not be commingled with other property of Debtor, but shall be segregated, held by Debtor
in trust for Secured Party, and immediately delivered to Secured Party in the form received, duly endorsed in blank where appropriate
to effectuate the provisions hereof, the same to be held by Secured Party as additional Collateral hereunder or, at Secured Party’
option, to be applied to payment of the Obligations, whether or not due and in any order; (q) in their sole discretion, Secured
Party may, at any time and from time to time during normal business hours, assign, transfer or deliver to any transferee of any
Obligations, any Collateral, whereupon Secured Party shall be fully discharged from all responsibility and the transferee shall
be vested with all powers and rights of Secured Party hereunder with respect thereto, but Secured Party shall retain all rights
and powers with respect to any Collateral not assigned, transferred or delivered; and (r) upon reasonable request of Secured Party,
at any time and from time to time, Debtor shall, at its cost and expense, execute and deliver to Secured Party reports as to the
Collateral listing all items thereof, describing the condition of same and setting forth the value thereof (lower of cost or market)
all in form and substance reasonably satisfactory to Secured Party. Whenever any act is referred to herein as being taken by the
Secured Party, it shall mean by the Agent appointed by all of the Lenders pursuant to Section 6 hereof.

 

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4.
The term Default as used in this Security Agreement shall mean any Event of Default, as such term is defined in the Notes.

 

5.
Upon the occurrence and during the continuance of any Default, Secured Party may, without notice to (except as herein set forth
or as set forth in the Notes) or demand upon Debtor, declare any Obligations immediately due and payable and Secured Party shall
have the following rights and remedies (to the extent permitted by applicable law and the Uniform Commercial Code then in effect
in the State of New York) in addition to all rights and remedies of a Secured Party under the UCC or of Secured Party under the
Obligations, all such rights and remedies being cumulative, not exclusive and enforceable alternatively, successively or concurrently:

 

(a)
Secured Party may, at any time and from time to time, with or without judicial process or the aid and assistance of others, (i)
enter upon any premises in which any Collateral may be located and, without resistance or interference by Debtor, take possession
of the Collateral, (ii) dispose of any part or all of the Collateral on any such premises, (iii) require Debtor to assemble and
make available to Secured Party at the expense of Debtor any part or all of the Collateral at any place and time designated by
Secured Party which is reasonably convenient to both parties, (iv) remove any part or all of the Collateral from any such premises
for the purpose of effecting sale or other disposition thereof (and if any of the Collateral consists of motor vehicles, Secured
Party may use Debtor’s license plates), and (v) sell, resell, lease, assign and deliver, grant options for or otherwise
dispose of any part or all of the Collateral in its then condition or following any commercially reasonable preparation or processing,
at public or private sale or proceedings or otherwise, by one or more contracts, in one or more parcels, at the same or different
times, with or without having the Collateral at the place of sale or other disposition, for cash and/or credit, and upon any terms,
at such place(s) and time(s) and to such person(s) as Secured Party deems best, all without demand, notice or advertisement whatsoever
except that where an applicable statute requires reasonable notice of sale or other disposition Debtor hereby agrees that the
sending of ten days’ notice by overnight mail, postage prepaid, to any address of Debtor set forth in this Security Agreement
shall be deemed reasonable notice thereof. If any Collateral is sold by Secured Party upon credit or for future delivery, Secured
Party shall not be liable for the failure of the purchaser to pay for same and in such event Secured Party may resell or otherwise
dispose of such Collateral. Secured Party may buy any part or all of the Collateral at any public sale and, if any part or all
of the Collateral is of a type customarily sold in a recognized market or is of the type which is the subject of widely distributed
standard price quotations, Secured Party may buy such Collateral at private sale and in each case may make payment therefor by
any means, whether by credit against the Obligations or otherwise. Secured Party may apply the cash proceeds actually received
from any sale or other disposition to the reasonable expenses of retaking, holding, preparing for sale, selling, leasing and the
like, to reasonable attorneys’ fees and all legal, travel and other expenses which may be incurred by Secured Party in attempting
to collect the Obligations, proceed against the Collateral or enforce this Security Agreement or in the prosecution or defense
of any action or proceeding related to the Obligations, the Collateral or this Security Agreement; and then to the Obligations
in such order and as to principal or interest as Secured Party may desire; and Debtor shall remain liable and will pay Secured
Party on demand any deficiency remaining, together with interest thereon at the highest rate then payable on the Obligations and
the balance of any expenses unpaid, with any surplus to be paid to Debtor, subject to any duty of Secured Party imposed by law
to the holder of any subordinate security interest in the Collateral known to Secured Party.

 

(b)
Secured Party may, at any time and from time to time, as appropriate, after the occurrence and during the continuance of a Default
set off and apply to the payment of the Obligations, any Collateral in or coming into the possession of Secured Party or their
agents, without notice to Debtor and in such manner as Secured Party may in their discretion determine.

 

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6.
Secured Party may designate and appoint a collateral agent (“Agent”), as attorney-in-fact of Debtor, irrevocably and
with power of substitution, which initial Agent shall be _____________, with authority to: endorse the name of Debtor on any notes,
acceptances, checks, drafts, money orders, instruments or other evidences of Collateral that may come into Secured Party’s
possession; sign the name of Debtor on any invoices, documents, assignments; execute proofs of claim and loss; execute endorsements,
assignments or other instruments of conveyance or transfer; adjust and compromise any claims under insurance policies or otherwise;
execute releases; and do all other acts and things necessary or advisable in the sole discretion of Secured Party to carry out
and enforce this Security Agreement or the Obligations. Neither Secured Party nor any designee or agent thereof shall be liable
for any acts of commission or omission done in good faith, for any error of judgment or for any mistake of fact or law. This power
of attorney being coupled with an interest is irrevocable while any Obligations shall remain unpaid.

 

7.
With respect to the enforcement of Secured Party’s rights under this Security Agreement, Debtor hereby releases Secured
Party and Agent from any claims, causes of action and demands at any time arising out of or with respect to this Security Agreement,
the Obligations, the Collateral and its use and/or any actions taken or omitted to be taken by Secured Party or Agent in good
faith with respect thereto, and Debtor hereby agrees to hold Secured Party and Agent harmless from and with respect to any and
all such claims, causes of action and demands.

 

8.
Secured Party’s prior recourse to any Collateral shall not constitute a condition of any demand, suit or proceeding for
payment or collection of the Obligations nor shall any demand, suit or proceeding for payment or collection of the Obligations
constitute a condition of any recourse by Secured Party to the Collateral. Any suit or proceeding by Secured Party to recover
any of the Obligations shall not be deemed a waiver of, or bar against, subsequent proceedings by Secured Party with respect to
any other Obligations and/or with respect to the Collateral. No act, omission or delay by Secured Party shall constitute a waiver
of their rights and remedies hereunder or otherwise. No single or partial waiver by Secured Party of any covenant, warranty, representation,
Default or right or remedy which they may have shall operate as a waiver of any other covenant, warranty, representation, Default,
right or remedy or of the same covenant, warranty, representation, Default, right or remedy on a future occasion. Debtor hereby
waives presentment, notice of dishonor and protest of all instruments included in or evidencing any Obligations or Collateral,
and all other notices and demands whatsoever (except as expressly provided herein).

 

9.
Debtor hereby agrees to pay, on demand, all out-of-pocket expenses reasonably incurred by Secured Party in connection with the
enforcement of the Notes, and this Security Agreement, including, without limitation, the fees and disbursements of counsel to
Secured Party.

 

10.
In the event of any litigation with respect to any matter connected with this Security Agreement, the Obligations, the Collateral
or the Notes, Debtor hereby waives the right to a trial by jury and all rights of setoff. Debtor hereby waives personal service
of any process in connection with any such action or proceeding and agrees that the service thereof may be made by certified or
registered mail directed to Debtor at any address of Debtor set forth in this Security Agreement. In the alternative, Secured
Party may in their discretion effect service upon Debtor in any other form or manner permitted by law.

 

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11.
Upon the payment in full or conversion of the Notes and satisfaction of all Obligations in accordance with the Notes, the security
interest granted hereby in the Collateral shall terminate and all rights to the Collateral under this Agreement shall revert to
Debtor. Upon any such termination, the Secured Party shall execute and deliver UCC–3 financing statement releases or other
documents of release reasonably requested by Debtor.

 

12.
Secured Party may assign their rights and obligation hereunder to any Affiliate of Secured Party provided that such Affiliate
assumes all of the liabilities or obligations of Secured Party hereunder. For purposes of this section, “Affiliate”
of any person means any other person or entity which, directly or indirectly, controls or is controlled by that person, or is
under common control with that person or entity. “Control” (including, with correlative meaning, the terms “controlled
by” and “under common control with”), as used with respect to any person or entity, means the possession, directly
or indirectly, of the power to direct or cause the direction of the management and policies of such person or entity, whether
through the ownership of voting securities, by contract or otherwise.

 

13.
All terms herein shall have the meanings as defined in the UCC, unless the context otherwise requires. No provision hereof shall
be modified, altered, waived, released, terminated or limited except by a written instrument expressly referring to this Security
Agreement and to such provision, and executed by the Party to be charged. The execution and delivery of this Security Agreement
has been authorized by the Board of Directors of Debtor and by any necessary vote or consent of shareholders of Debtor. This Security
Agreement and all Obligations shall be binding upon the successors and assigns of Debtor and shall, together with the rights and
remedies of Secured Party hereunder, inure to the benefit of Secured Party, their executors, administrators, successors, permitted
endorsees and permitted assigns. This Security Agreement and the Obligations shall be governed in all respects by the laws of
the State of New York applicable to contracts executed and to be performed in such state. If any term of this Security Agreement
shall be held to be invalid, illegal or unenforceable, the validity of all other terms hereof shall in no way be affected thereby.
Secured Party is authorized to annex hereto any schedules referred to herein. Debtor acknowledges receipt of a copy of this Security
Agreement.

 

14.
All notices and other communications under this Agreement shall be in writing and shall be deemed given when delivered personally,
by overnight mail or delivery service or mailed by certified mail, return receipt requested, to the parties.

 

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IN
WITNESS WHEREOF, the undersigned have executed or caused this security agreement to be executed on the date first above set forth.

 

	 	COMPANY:

	 	 
	 	PRESSURE BIOSCIENCES, INC. 
	 	 	 
	 	By:	
	 	Name:	Richard
    T. Schumacher
	 	Title:	President
    and CEO

 

Address
of Debtor:

 

	14
                                         Norfolk Avenue

        South
        Easton, Massachusetts 02375

 

Secured
Party:

 

________________________________

 

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SCHEDULE
A

 

1.
Promissory Note in the principal amount of $385,000, dated November 15, 2019, payable to ___________.

 

2.
Promissory Note in the principal amount of $495,000, dated December 3, 2019, payable to ______________.

 

3.
Promissory Note in the principal amount of $275,000, dated December 18, 2019, payable to ______________.

 

4.

 

5.

 

6.

 

7.

 

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SCHEDULE
B

 

As
used in this Agreement, the term “Collateral” means, collectively, wherever located, whether now owned or hereafter
acquired or now existing or hereafter acquired or created, all right, title and interest of the Company in and to all of its assets,
including, without limitation: (i) accounts, chattel paper, deposit accounts, documents, general intangibles (including, but not
limited to intellectual property, patents, payment intangibles, software, licenses, franchises and customer information), goods
(including, but not limited to equipment, fixtures and inventory), instruments, investment property, letter-of-credit rights,
money, other personal property, software, any commercial tort claims; (ii) to the extent not referred to in clause (i) of this
sentence, all (A) supporting obligations and incidental property rights incident to, arising or accruing pursuant to or otherwise
relating to any of the things referred to in clause (i) of this sentence, whether arising or accruing from any action taken by
the Company or the Collateral Agent or otherwise, (B) proceeds of any of the items referred to in clauses (i) and (ii)(A) of this
sentence and (C) books and records relating to any of the items referred to in clauses (i) and (ii)(A) and (B) of this sentence.

 

    	8Exhibit
10.5

 

REGISTRATION
RIGHTS AGREEMENT

 

This
REGISTRATION RIGHTS AGREEMENT (this “Agreement”), dated as of the date listed on the signature pages
hereto, is by and among Pressure BioSciences, Inc., a Massachusetts corporation (the “Company”), and each of
the undersigned buyers (each, a “Buyer,” and collectively, the “Buyers”).

 

RECITALS

 

A.
In connection with the Securities Purchase Agreement by and among the parties hereto, dated as of the date hereof (the “Securities
Purchase Agreement”), the Company has agreed, upon the terms and subject to the conditions of the Securities Purchase
Agreement, to issue and sell to each Buyer units consisting of (i) a 10% senior secured convertible promissory note (the “Note”),
(ii) Warrants (as defined in the Securities Purchase Agreement) to purchase Common Stock, and (iii) shares of Common Stock issuable
upon the conversion of the Note (“Note Shares”) and exercise of the Warrants (“Warrant Shares”).

 

B.
To induce the Buyers to consummate the transactions contemplated by the Securities Purchase Agreement, the Company has agreed
to provide certain registration rights under the Securities Act of 1933, as amended, and the rules and regulations thereunder,
or any similar successor statute (collectively, the “1933 Act”), and applicable state securities laws.

 

AGREEMENT

 

NOW,
THEREFORE, in consideration of the premises and the mutual covenants contained herein and for other good and valuable consideration,
the receipt and sufficiency of which are hereby acknowledged, the Company and each of the Buyers hereby agree as follows:

 

1.
Definitions.

 

Capitalized
terms used herein and not otherwise defined herein shall have the respective meanings set forth in the Securities Purchase Agreement.
As used in this Agreement, the following terms shall have the following meanings:

 

(a)
“Business Day” means any day other than Saturday, Sunday or any other day on which commercial banks in New
York, New York are authorized or required by law to remain closed.

 

(b)
“Closing Date” shall have the meaning set forth in the Securities Purchase Agreement.

 

(c)
“Company Counsel” means Lucosky Brookman LLP.

 

(d)
“Effective Date” means the date that the applicable Registration Statement has been declared effective by the
SEC.

 

    	 

    	 

    

 

(e)
“Effectiveness Deadline” means (i) with respect to the initial Registration Statement required to be filed
pursuant to Section 2(a), the earlier of the (A) 90th calendar day after the Filing Deadline (or the 120th
calendar day after the Filing Deadline in the event that such Registration Statement is subject to Full Review by the SEC), and
(B) the fifth day after the date the Company is notified (orally or in writing, whichever is earlier) by the SEC that such Registration
Statement will not be reviewed or will not be subject to further review, and (ii) with respect to any additional Registration
Statements that may be required to be filed by the Company pursuant to this Agreement, the earlier of the (A) 90th calendar day
following the date on which the Company was required to file such additional Registration Statement and (B) the fifth day after
the date the Company is notified (orally or in writing, whichever is earlier) by the SEC that such Registration Statement will
not be reviewed or will not be subject to further review.

 

(f)
“Filing Deadline” means (i) with respect to the initial Registration Statement required to be filed pursuant
to Section 2(a), the 30th calendar day after the final closing date of the Company’s offering of Series AA Convertible
Preferred Stock, and (ii) with respect to any additional Registration Statements that may be required to be filed by the Company
pursuant to this Agreement, the date on which the Company was required to file such additional Registration Statement pursuant
to the terms of this Agreement.

 

(g)
“Full Review” in respect of any Registration Statement shall mean an instance where the staff of the SEC does
not inform the Company either that the Registration Statement will not be reviewed or that such review will be on a limited, monitor
or expedited (or other similar) basis.

 

(h)
“Investor” means a Buyer or any transferee or assignee of any Registrable Securities, Notes or Warrants, as
applicable, to whom a Buyer assigns its rights under this Agreement and who agrees to become bound by the provisions of this Agreement
in accordance with Section 9 and any transferee or assignee thereof to whom a transferee or assignee of any Registrable Securities
or Warrants, as applicable, assigns its rights under this Agreement and who agrees to become bound by the provisions of this Agreement
in accordance with Section 9.

 

(i)
“Person” means an individual, a limited liability company, a partnership, a joint venture, a corporation, a
trust, an unincorporated organization or a government or any department or agency thereof.

 

(j)
“register,” “registered,” and “registration” refer to a registration
effected by preparing and filing one or more Registration Statements in compliance with the 1933 Act and pursuant to Rule 415
and the declaration of effectiveness of such Registration Statement(s) by the SEC.

 

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(k)
“Registrable Securities” means (i) the Warrant Shares, (ii) the Note Shares, and (iii) any capital stock of
the Company issued or issuable with respect to the Note, the Warrant, or any other shares of Common Stock issuable pursuant to
the Transaction Documents, including without limitation, (1) as a result of any stock split, stock dividend, recapitalization,
exchange or similar event or otherwise and (2) shares of capital stock of the Company into which the shares of Common Stock (as
defined in the Securities Purchase Agreement) are converted or exchanged and shares of capital stock of a Successor Entity (as
defined in the Warrants) into which the shares of Common Stock are converted or exchanged, in each case, without regard to any
limitations on exercise of the Warrants and conversion of the Note, provided, however, that Registrable Securities
shall not include any securities of the Company that have previously been registered and remain subject to a currently effective
registration statement or which have been sold to the public either pursuant to a registration statement or Rule 144, or which
have been sold in a private transaction in which the transferor’s rights under this Section 1 are not assigned, or which
may be sold immediately without registration under the Securities Act and without volume restrictions pursuant to Rule 144, or
any capital stock of the Company issued or issuable with respect to the Notes that are issued pursuant to any exchange of previously
issued securities.

 

(l)
“Registration Statement” means a registration statement or registration statements of the Company filed under
the 1933 Act covering Registrable Securities.

 

(m)
“Required Holders” means the holders of at least a majority of the Registrable Securities.

 

(n)
“Required Registration Amount” means the Registrable Securities required to registered hereunder.

 

(o)
“Response Deadline” means the date which is ten (10) Business Days after receipt of a letter of comment or
telephonic comments from the SEC.

 

(p)
“Rule 144” means Rule 144 promulgated by the SEC under the 1933 Act, as such rule may be amended from time
to time, or any other similar or successor rule or regulation of the SEC that may at any time permit the Investors to sell securities
of the Company to the public without registration.

 

(q)
“Rule 415” means Rule 415 promulgated by the SEC under the 1933 Act, as such rule may be amended from time
to time, or any other similar or successor rule or regulation of the SEC providing for offering securities on a continuous or
delayed basis.

 

(r)
“SEC” means the United States Securities and Exchange Commission or any successor thereto.

 

2.
Registration.

 

(a)
Mandatory Registration. The Company shall prepare and, as soon as practicable, but in no event later than the Filing Deadline,
file with the SEC an initial Registration Statement on Form S-1 covering the resale of all of the Registrable Securities; provided
that such initial Registration Statement shall register for resale at least the number of shares of Common Stock equal to the
Required Registration Amount as of the date such Registration Statement is initially filed with the SEC. Such initial Registration
Statement, and each other Registration Statement required to be filed pursuant to the terms of this Agreement, shall contain (except
if otherwise directed by the Required Holders) the “Selling Stockholders” and “Plan of Distribution”
sections in substantially the form attached hereto as Exhibit A. The Company shall use its best efforts to have
such initial Registration Statement, and each other Registration Statement required to be filed pursuant to the terms of this
Agreement, declared effective by the SEC as soon as practicable.

 

(b)
[intentionally omitted]

 

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(c)
Sufficient Number of Shares Registered. In the event the number of shares available under any Registration Statement is
insufficient to cover all of the Registrable Securities required to be covered by such Registration Statement or an Investor’s
allocated portion of the Registrable Securities pursuant to Section 2(f), the Company shall amend such Registration Statement
(if permissible), or file with the SEC a new Registration Statement (on the short form available therefor, if applicable), or
both, so as to cover at least the Required Registration Amount as of the Trading Day immediately preceding the date of the filing
of such amendment or new Registration Statement, in each case, as soon as practicable, but in any event not later than fifteen
(15) days after the necessity therefor arises (but taking account of any Staff position with respect to the date on which the
Staff will permit such amendment to the Registration Statement and/or such new Registration Statement (as the case may be) to
be filed with the SEC). The Company shall use its best efforts to cause such amendment to such Registration Statement and/or such
new Registration Statement (as the case may be) to become effective as soon as practicable following the filing thereof with the
SEC. For purposes of the foregoing provision, the number of shares available under a Registration Statement shall be deemed “insufficient
to cover all of the Registrable Securities” if at any time the number of shares of Common Stock available for resale is
insufficient.

 

(d)
Effect of Failure to File, Respond to and Maintain Effectiveness of any Registration Statement. If (i) a Registration Statement
covering the resale of all of the Registrable Securities required to be covered thereby (disregarding any reduction pursuant to
Section 2(e)) and required to be filed by the Company pursuant to this Agreement is (A) not filed with the SEC on or before the
Filing Deadline for such Registration Statement (a “Filing Failure”), (B) SEC comments are not responded to
by the Response Deadline (“Response Failure”), or (C) not declared effective by the SEC on or before the Effectiveness
Deadline for such Registration Statement (an “Effectiveness Failure”) (it being understood that if on the Business
Day immediately following the Effective Date for such Registration Statement the Company shall not have filed a “final”
prospectus for such Registration Statement with the SEC under Rule 424(b) in accordance with Section 3(b) (whether or not such
a prospectus is technically required by such rule), the Company shall be deemed to not have satisfied this clause (i)(C) and such
event shall be deemed to be an Effectiveness Failure), (ii) other than during an Allowable Grace Period (as defined below), on
any day after the Effective Date of a Registration Statement, sales of all of the Registrable Securities required to be included
on such Registration Statement (disregarding any reduction pursuant to Section 2(e)) cannot be made pursuant to such Registration
Statement (including, without limitation, because of a failure to keep such Registration Statement effective, a failure to disclose
such information as is necessary for sales to be made pursuant to such Registration Statement, on or after the Closing Date a
suspension or delisting of (or a failure to timely list) the Common Stock on an Eligible Market (as defined in the Securities
Purchase Agreement), or a failure to register a sufficient number of shares of Common Stock or by reason of a stop order) or the
prospectus contained therein is not available for use for any reason (a “Maintenance Failure”), or (iii) at
any time when a Registration Statement is not effective for any reason or the prospectus contained therein is not available for
use for any reason, the Company fails to file with the SEC any required reports under Section 13 or 15(d) of the 1934 Act such
that it is not in compliance with Rule 144(c)(1) (or Rule 144(i)(2), if applicable) (a “Current Public Information Failure”)
as a result of which any of the Investors are unable to sell Registrable Securities without restriction under Rule 144 (including,
without limitation, volume restrictions), then, as partial relief for the damages to any holder by reason of any such delay in,
or reduction of, its ability to sell the underlying shares of Common Stock (which remedy shall not be exclusive of any other remedies
available at law or in equity), the Company shall pay to each holder of Registrable Securities relating to such Registration Statement
an amount in cash equal to one percent (1%) of such Investor’s Purchase Price on the Closing Date (1) on the date of such
Filing Failure, Response Failure, Effectiveness Failure, Maintenance Failure, Response Failure or Current Public Information Failure,
as applicable, and (2) on every thirty (30) day anniversary or portion thereof of (I) a Filing Failure until such Filing Failure
is cured; (II) an Effectiveness Failure until such Effectiveness Failure is cured; (III) a Maintenance Failure until such Maintenance
Failure is cured; (IV) a Response Failure until a response is properly filed with the SEC; and (V) a Current Public Information
Failure until the earlier of (i) the date such Current Public Information Failure is cured and (ii) such time that such public
information is no longer required pursuant to Rule 144 (in each case, pro rated for periods totaling less than thirty (30) days).
The payments to which a holder of Registrable Securities shall be entitled pursuant to this Section 2(e) are referred to herein
as “Registration Delay Payments.” Following the initial Registration Delay Payment for any particular event
or failure (which shall be paid on the date of such event or failure, as set forth above), without limiting the foregoing, if
an event or failure giving rise to the Registration Delay Payments is cured prior to any thirty (30) day anniversary of such event
or failure, then such Registration Delay Payment shall be made on the third (3rd) Business Day after such cure. Notwithstanding
the foregoing, no Registration Delay Payments shall be owed to an Investor (other than with respect to a Maintenance Failure resulting
from a suspension of listing or quotation or delisting of (or a failure to timely list or quote) the Common Stock on the Principal
Market) with respect to any period during which all of such Investor’s Registrable Securities may be sold by such Investor
without restriction under Rule 144 (including, without limitation, volume restrictions) and without the need for current public
information required by Rule 144(c)(1) (or Rule 144(i)(2), if applicable). Notwithstanding the foregoing, the Company shall not
be obligated to pay any such liquidated damages pursuant to this Section 2(d) if the Company is unable to fulfill its registration
obligations as a result of rules, regulations, positions or releases issued or actions taken by the Commission pursuant to its
authority with respect to “Rule 415”, and the Company registers at such time the maximum number of shares of Common
Stock permissible upon consultation with the staff of the SEC (the “Staff”) or as contemplated pursuant to
Section 2(e) below. The maximum penalties payable hereunder shall not exceed 6% of the Purchase Price. Penalties shall cease to
accrue at such time as the Registrable Securities may be sold under Rule 144 and the Company uses commercially reasonable efforts
to provide appropriate legal opinions.

 

    	4

    	 

    

 

(e)
Offering. Notwithstanding anything to the contrary contained in this Agreement, in the event the Staff or the SEC seeks
to characterize any offering pursuant to a Registration Statement filed pursuant to this Agreement as constituting an offering
of securities by, or on behalf of, the Company, or in any other manner, such that the Staff or the SEC do not permit such Registration
Statement to become effective and used for resales in a manner that does not constitute such an offering and that permits the
continuous resale at the market by the Investors participating therein (or as otherwise may be acceptable to each Investor) without
being named therein as an “underwriter,” then the Company shall reduce the number of Warrant Shares to be included
in such Registration Statement by all investors until such time as the Staff and the SEC shall so permit such Registration Statement
to become effective as aforesaid. In making such reduction, the Company shall reduce the number of Warrant Shares to be included
by all investors on a pro rata basis (based upon the number of Registrable Securities otherwise required to be included for each
investor) unless the inclusion of Warrant Shares by a particular investor or a particular set of investors are resulting in the
Staff or the SEC’s “by or on behalf of the Company” offering position, in which event the Warrant Shares held
by such investor or set of investors shall be the only shares subject to reduction (and if by a set of investors on a pro rata
basis by such investors or on such other basis as would result in the exclusion of the least number of shares by all such investors).
In the event the reduction in the number of Warrant Shares to be included in such Registration Statement is not sufficient for
the Staff and the SEC to permit such Registration Statement to become effective, the Company shall reduce the number of shares
underlying the Notes in a similar manner to the reduction in the number of Warrant Shares described above. In addition, in the
event that the Staff or the SEC requires any Investor seeking to sell securities under a Registration Statement filed pursuant
to this Agreement to be specifically identified as an “underwriter” in order to permit such Registration Statement
to become effective, and such Investor does not consent to being so named as an underwriter in such Registration Statement, then,
in each such case, the Company shall reduce the total number of Registrable Securities to be registered on behalf of such Investor,
until such time as the Staff or the SEC does not require such identification or until such Investor accepts such identification
and the manner thereof. In the event of any reduction in Registrable Securities pursuant to this paragraph, an affected Investor
shall have the right to require, upon delivery of a written request to the Company signed by such Investor, the Company to file
a registration statement within thirty (30) calendar days of such request (subject to any restrictions imposed by Rule 415 or
required by the Staff or the SEC) for resale by such Investor in a manner acceptable to such Investor, and the Company shall following
such request cause to be and keep effective such registration statement in the same manner as otherwise contemplated in this Agreement
for registration statements hereunder, in each case, until such time as: (i) all Registrable Securities held by such Investor
have been registered and sold pursuant to an effective Registration Statement in a manner acceptable to such Investor or (ii)
all Registrable Securities may be resold by such Investor without restriction (including, without limitation, volume limitations)
pursuant to Rule 144 (taking account of any Staff position with respect to “affiliate” status) and without the need
for current public information required by Rule 144(c)(1) (or Rule 144(i)(2), if applicable) or (iii) such Investor agrees to
be named as an underwriter in any such Registration Statement in a manner acceptable to such Investor as to all Registrable Securities
held by such Investor and that have not theretofore been included in a Registration Statement under this Agreement (it being understood
that the special demand right under this sentence may be exercised by an Investor multiple times and with respect to limited amounts
of Registrable Securities in order to permit the resale thereof by such Investor as contemplated above). Any reduction made to
securities included in a Registration Statement in accordance with this Section 2(e) shall not constitute a Filing Failure, Effectiveness
Failure or a Maintenance Failure and shall not be subject to the payment requirements under Section 2(d).

 

(f)
Allocation of Registrable Securities. The initial number of Registrable Securities included in any Registration Statement
and any increase in the number of Registrable Securities included therein shall be allocated pro rata among the Investors based
on the number of Registrable Securities held by each Investor at the time such Registration Statement covering such initial number
of Registrable Securities or increase thereof is declared effective by the SEC. In the event that an Investor sells or otherwise
transfers any of such Investor’s Registrable Securities, each transferee or assignee (as the case may be) that becomes an
Investor shall be allocated a pro rata portion of the then-remaining number of Registrable Securities included in such Registration
Statement for such transferor or assignee (as the case may be). Any shares of Common Stock included in a Registration Statement
and which remain allocated to any Person which ceases to hold any Registrable Securities covered by such Registration Statement
shall be allocated to the remaining Investors, pro rata based on the number of Registrable Securities then held by such Investors
which are covered by such Registration Statement.

 

    	5

    	 

    

 

(g)
Inclusion of Other Securities. Other than as set forth in this Agreement or in the Securities Purchase Agreement, in no
event shall the Company include any securities other than Registrable Securities on any Registration Statement without the prior
written consent of the Required Holders. Until the Effective Date, the Company shall not enter into any agreement providing any
registration rights to any of its security holders that have any priority to any of the Investor’s rights contained in this
Agreement or adversely affect any Investor’s rights under this Agreement.

 

3.
Related Obligations.

 

The
Company shall use its best efforts to effect the registration of the Registrable Securities in accordance with the intended method
of disposition thereof, and, pursuant thereto, the Company shall have the following obligations:

 

(a)
The Company shall prepare and file with the SEC a Registration Statement with respect to all the Registrable Securities (but in
no event later than the applicable Filing Deadline) and use its best efforts to cause such Registration Statement to become effective
as soon as practicable after such filing (but in no event later than the Effectiveness Deadline). Subject to Allowable Grace Periods,
the Company shall keep each Registration Statement effective (and the prospectus contained therein available for use) pursuant
to Rule 415 for resales by the Investors on a delayed or continuous basis at then-prevailing market prices (and not fixed prices)
at all times until the earlier of (i) the date as of which all of the Investors may sell all of the Registrable Securities required
to be covered by such Registration Statement (disregarding any reduction pursuant to Section 2(e)) without restriction pursuant
to Rule 144 (including, without limitation, volume restrictions) and without the need for current public information required
by Rule 144(c)(1) (or Rule 144(i)(2), if applicable) or (ii) the date on which the Investors shall have sold all of the Registrable
Securities covered by such Registration Statement (the “Registration Period”). Notwithstanding anything to
the contrary contained in this Agreement, the Company shall ensure that, when filed and at all times while effective, each Registration
Statement (including, without limitation, all amendments and supplements thereto) and the prospectus (including, without limitation,
all amendments and supplements thereto) used in connection with such Registration Statement (1) shall not contain any untrue statement
of a material fact or omit to state a material fact required to be stated therein, or necessary to make the statements therein
(in the case of prospectuses, in the light of the circumstances in which they were made) not misleading and (2) will disclose
(whether directly or through incorporation by reference to other SEC filings to the extent permitted) all material information
regarding the Company and its securities.

 

    	6

    	 

    

 

(b)
Subject to Section 3(r) of this Agreement, the Company shall prepare and file with the SEC such amendments (including, without
limitation, post-effective amendments) and supplements to each Registration Statement and the prospectus used in connection with
each such Registration Statement, which prospectus is to be filed pursuant to Rule 424 promulgated under the 1933 Act, as may
be necessary to keep each such Registration Statement effective at all times during the Registration Period for such Registration
Statement, and, during such period, comply with the provisions of the 1933 Act with respect to the disposition of all Registrable
Securities of the Company required to be covered by such Registration Statement until such time as all of such Registrable Securities
shall have been disposed of in accordance with the intended methods of disposition by the seller or sellers thereof as set forth
in such Registration Statement; provided, however, by 9:30 a.m. (New York time) no later than the second Business Day immediately
following each Effective Date, the Company shall file with the SEC in accordance with Rule 424(b) under the 1933 Act the final
prospectus to be used in connection with sales pursuant to the applicable Registration Statement (whether or not such a prospectus
is technically required by such rule). In the case of amendments and supplements to any Registration Statement which are required
to be filed pursuant to this Agreement (including, without limitation, pursuant to this Section 3(b)) by reason of the Company
filing a report on Form 10-K, Form 10-Q, Form 8-K or any analogous report under the Securities Exchange Act of 1934, as amended
(the “1934 Act”), the Company shall have incorporated such report by reference into such Registration Statement,
if applicable, or shall file such amendments or supplements with the SEC on the same day on which the 1934 Act report is filed
which created the requirement for the Company to amend or supplement such Registration Statement.

 

(c)
The Company shall (A) permit each Investor to review and provide comments to the Company and Company Counsel, with respect to
(i) each Registration Statement at least two (2) Business Days prior to its filing with the SEC and (ii) all amendments and supplements
to each Registration Statement (including, without limitation, the prospectus contained therein) (except for Reports on Form 10-K,
Form 10-Q, Form 8-K, and any similar or successor reports) within a reasonable number of days prior to their filing with the SEC,
and (B) not file any Registration Statement or amendment or supplement thereto in a form to which the Required Holders reasonably
objects, such objections to be delivered to the Company within a reasonable period of time.

 

(d)
The Company shall promptly furnish to each Investor whose Registrable Securities are included in any Registration Statement, without
charge, (i) after the same is prepared and filed with the SEC, at least one (1) copy of each Registration Statement and any amendment(s)
and supplement(s) thereto, including, without limitation, financial statements and schedules, all documents incorporated therein
by reference, if requested by an Investor, all exhibits and each preliminary prospectus (unless such Registration Statement is
available on EDGAR), (ii) upon the effectiveness of each Registration Statement, ten (10) copies of the prospectus included in
such Registration Statement and all amendments and supplements thereto (unless such Registration Statement is available on EDGAR)
and (iii) such other documents, including, without limitation, copies of any preliminary or final prospectus, as such Investor
may reasonably request from time to time (unless such document is available on EDGAR) in order to facilitate the disposition of
the Registrable Securities owned by such Investor.

 

(e)
The Company shall use its reasonable best efforts to (i) register and qualify, unless an exemption from registration and qualification
applies, the resale by Investors of the Registrable Securities covered by a Registration Statement under such other securities
or “blue sky” laws of all applicable jurisdictions in the United States, (ii) prepare and file in those jurisdictions,
such amendments (including, without limitation, post-effective amendments) and supplements to such registrations and qualifications
as may be necessary to maintain the effectiveness thereof during the Registration Period, (iii) take such other actions as may
be necessary to maintain such registrations and qualifications in effect at all times during the Registration Period, and (iv)
take all other actions reasonably necessary or advisable to qualify the Registrable Securities for sale in such jurisdictions;
provided, however, the Company shall not be required in connection therewith or as a condition thereto to (x) qualify to do business
in any jurisdiction where it would not otherwise be required to qualify but for this Section 3(e), (y) subject itself to general
taxation in any such jurisdiction, or (z) file a general consent to service of process in any such jurisdiction. The Company shall
promptly notify each Investor who holds Registrable Securities of the receipt by the Company of any notification with respect
to the suspension of the registration or qualification of any of the Registrable Securities for sale under the securities or “blue
sky” laws of any jurisdiction in the United States or its receipt of actual notice of the initiation or threatening of any
proceeding for such purpose.

 

    	7

    	 

    

 

(f)
The Company shall either notify each Investor in writing or file a current Report on Form 8-K with the SEC providing disclosure
of the happening of any event, as promptly as practicable after becoming aware of such event, as a result of which the prospectus
included in a Registration Statement, as then in effect, includes an untrue statement of a material fact or omission to state
a material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances under
which they were made, not misleading (provided that in no event shall such notice contain any material, non-public information
regarding the Company or any of its Subsidiaries), and, subject to Section 3(r), promptly prepare a supplement or amendment to
such Registration Statement and such prospectus contained therein to correct such untrue statement or omission and deliver ten
(10) copies of such supplement or amendment to each Investor (or such other number of copies as such Investor may reasonably request)
(unless such supplements or amendments are available on EDGAR). The Company shall also promptly notify each Investor in writing
(i) when a prospectus or any prospectus supplement or post-effective amendment has been filed, when a Registration Statement or
any post-effective amendment has become effective (notification of such effectiveness shall be delivered to each Investor by facsimile
or e-mail on the same day of such effectiveness and by overnight mail), and when the Company receives written notice from the
SEC that a Registration Statement or any post-effective amendment will be reviewed by the SEC, (ii) of any request by the SEC
for amendments or supplements to a Registration Statement or related prospectus or related information, (iii) of the Company’s
reasonable determination that a post-effective amendment to a Registration Statement would be appropriate; and (iv) of the receipt
of any request by the SEC or any other federal or state governmental authority for any additional information relating to the
Registration Statement or any amendment or supplement thereto or any related prospectus. The Company shall respond as promptly
as practicable to any comments received from the SEC with respect to each Registration Statement or any amendment thereto (it
being understood and agreed that the Company’s response to any such comments shall be delivered to the SEC no later than
ten (10) Business Days after the receipt thereof).

 

(g)
The Company shall (i) use its reasonable best efforts to prevent the issuance of any stop order or other suspension of effectiveness
of each Registration Statement or the use of any prospectus contained therein, or the suspension of the qualification, or the
loss of an exemption from qualification, of any of the Registrable Securities for sale in any jurisdiction and, if such an order
or suspension is issued, to obtain the withdrawal of such order or suspension at the earliest possible moment and (ii) notify
each Investor who holds Registrable Securities of the issuance of such order and the resolution thereof or its receipt of actual
notice of the initiation or threat of any proceeding for such purpose.

 

    	8

    	 

    

 

(h)
[RESERVED]

 

(i)
If any Investor may be required under applicable securities law to be described in any Registration Statement as an underwriter
and such Investor consents to so being named an underwriter, upon the written request of such Investor, the Company shall make
available for inspection by (i) such Investor, (ii) legal counsel for such Investor and (iii) one (1) firm of accountants or other
agents retained by such Investor (collectively, the “Inspectors”), all pertinent financial and other records,
and pertinent corporate documents and properties of the Company (collectively, the “Records”), as shall be
reasonably deemed necessary by each Inspector, and cause the Company’s officers, directors and employees to supply all information
which any Inspector may reasonably request; provided, however, each Inspector shall agree in writing to hold in strict confidence
and not to make any disclosure (except to such Investor) or use of any Record or other information which the Company’s board
of directors determines in good faith to be confidential, and of which determination the Inspectors are so notified, unless (1)
the disclosure of such Records is necessary to avoid or correct a misstatement or omission in any Registration Statement or is
otherwise required under the 1933 Act, (2) the release of such Records is ordered pursuant to a final, non-appealable subpoena
or order from a court or government body of competent jurisdiction, or (3) the information in such Records has been made generally
available to the public other than by disclosure in violation of this Agreement or any other Transaction Document (as defined
in the Securities Purchase Agreement). Such Investor agrees that it shall, upon learning that disclosure of such Records is sought
in or by a court or governmental body of competent jurisdiction or through other means, give prompt notice to the Company and
allow the Company, at its expense, to undertake appropriate action to prevent disclosure of, or to obtain a protective order for,
the Records deemed confidential. Nothing herein (or in any other confidentiality agreement between the Company and such Investor,
if any) shall be deemed to limit any Investor’s ability to sell Registrable Securities in a manner which is otherwise consistent
with applicable laws and regulations.

 

(j)
The Company shall hold in confidence and not make any disclosure of information concerning an Investor provided to the Company
unless (i) disclosure of such information is necessary to comply with federal or state securities laws, (ii) the disclosure of
such information is necessary to avoid or correct a misstatement or omission in any Registration Statement or is otherwise required
to be disclosed in such Registration Statement pursuant to the 1933 Act, (iii) the release of such information is ordered pursuant
to a subpoena or other final, non-appealable order from a court or governmental body of competent jurisdiction, or (iv) such information
has been made generally available to the public other than by disclosure in violation of this Agreement or any other Transaction
Document. The Company agrees that it shall, upon learning that disclosure of such information concerning an Investor is sought
in or by a court or governmental body of competent jurisdiction or through other means, give prompt written notice to such Investor
and allow such Investor, at such Investor’s expense, to undertake appropriate action to prevent disclosure of, or to obtain
a protective order for, such information.

 

    	9

    	 

    

 

(k)
Without limiting any obligation of the Company under the Securities Purchase Agreement, on and after the Closing Date, the Company
shall use its best efforts either to (i) cause all of the Registrable Securities covered by each Registration Statement to be
listed on each securities exchange on which securities of the same class or series issued by the Company are then listed, if any,
if the listing of such Registrable Securities is then permitted under the rules of such exchange, (ii) secure designation and
quotation of all of the Registrable Securities covered by each Registration Statement on the OTC Marketplace, or (iii) if, despite
the Company’s best efforts to satisfy the preceding clauses (i) or (ii) the Company is unsuccessful in satisfying the preceding
clauses (i) or (ii), without limiting the generality of the foregoing, to use its best efforts to arrange for at least two market
makers to register with the Financial Industry Regulatory Authority, Inc. (“FINRA”) as such with respect to
such Registrable Securities. In addition, the Company shall cooperate with each Investor and any broker or dealer through which
any such Investor proposes to sell its Registrable Securities in effecting a filing with FINRA pursuant to FINRA Rule 5110 as
requested by such Investor. The Company shall pay all fees and expenses in connection with satisfying its obligations under this
Section 3(k).

 

(l)
To the extent that any registration statement filed pursuant to this Agreement has been declared effective by the SEC or restricted
legends have been removed pursuant to Section 5 of the Securities Purchase Agreement, then the Company shall cooperate with the
Investors who hold Registrable Securities being offered and, to the extent applicable, facilitate the timely preparation and delivery
of certificates (not bearing any restrictive legend) representing the Registrable Securities to be offered pursuant to a Registration
Statement and enable such certificates to be in such denominations or amounts (as the case may be) as the Investors may reasonably
request from time to time and registered in such names as the Investors may request, or, if requested by an Investor and the Common
Stock is traded through the facilities of the DTC (as defined below), credit such aggregate number of Registrable Securities to
be offered by such Investor to such Investor’s or its designee’s balance account with The Depository Trust Company
(“DTC”) through its Deposit/Withdrawal at Custodian system.

 

(m)
If reasonably requested by an Investor, the Company shall as soon as practicable after receipt of notice from such Investor and
subject to Section 3(o) hereof, (i) incorporate in a prospectus supplement or post-effective amendment such information as an
Investor reasonably requests to be included therein, but only as to which information the Company Counsel agrees (which agreement
shall not be unreasonably withheld), relating to the sale and distribution of Registrable Securities, including, without limitation,
information with respect to the number of Registrable Securities being offered or sold, the purchase price being paid therefor
and any other terms of the offering of the Registrable Securities to be sold in such offering; (ii) make all required filings
of such prospectus supplement or post-effective amendment after being notified of the matters to be incorporated in such prospectus
supplement or post-effective amendment; and (iii) supplement or make amendments to any Registration Statement or prospectus contained
therein if reasonably requested by an Investor holding any Registrable Securities.

 

(n)
The Company shall otherwise use its best efforts to comply with all applicable rules and regulations of the SEC in connection
with any registration hereunder.

 

    	10

    	 

    

 

(o)
Notwithstanding anything to the contrary herein (but subject to the last sentence of this Section 3(r)), at any time after the
Effective Date of a particular Registration Statement, the Company may delay the disclosure of material, non-public information
concerning the Company or any of its Subsidiaries the disclosure of which at the time is not, in the good faith opinion of the
board of directors of the Company, in the best interest of the Company and, in the opinion of Company Counsel, otherwise required
(a “Grace Period”), provided that the Company shall promptly notify the Investors in writing of the (i) existence
of material, non-public information giving rise to a Grace Period (provided that in each such notice the Company shall not disclose
the content of such material, non-public information to any of the Investors) and the date on which such Grace Period will begin
and (ii) date on which such Grace Period ends, provided further that (I) no Grace Period shall exceed twenty (20) consecutive
days and during any three hundred sixty five (365) day period all such Grace Periods shall not exceed an aggregate of forty-five
(45) days, (II) the first day of any Grace Period must be at least five (5) Trading Days after the last day of any prior Grace
Period and (III) no Grace Period may exist during the thirty (30) Trading Day period immediately following the Effective Date
of such Registration Statement (provided that such thirty (30) Trading Day period shall be extended by the number of Trading Days
during such period and any extension thereof contemplated by this proviso during which such Registration Statement is not effective
or the prospectus contained therein is not available for use) (each, an “Allowable Grace Period”). For purposes
of determining the length of a Grace Period above, such Grace Period shall begin on and include the date the Investors receive
the notice referred to in clause (i) above and shall end on and include the later of the date the Investors receive the notice
referred to in clause (ii) above and the date referred to in such notice. The provisions of the first sentence of Section 3(f)
and the provisions of Section 3(g) hereof shall not be applicable during the period of any Allowable Grace Period. Upon expiration
of each Grace Period, the Company shall again be bound by the first sentence of Section 3(f) and the provisions of Section 3(g)
with respect to the information giving rise thereto unless such material, non-public information is no longer applicable. Notwithstanding
anything to the contrary contained in this Section 3(r), the Company shall cause its transfer agent to deliver unlegended shares
of Common Stock to a transferee of an Investor in accordance with the terms of the Securities Purchase Agreement in connection
with any sale of Registrable Securities with respect to which such Investor has entered into a contract for sale, and delivered
a copy of the prospectus included as part of the particular Registration Statement (unless an exemption from such prospectus delivery
requirement exists), prior to such Investor’s receipt of the notice of a Grace Period and for which the Investor has not
yet settled.

 

4.
Obligations of the Investors.

 

(a)
At least five (5) Business Days prior to the first anticipated filing date of each Registration Statement, the Company shall notify
each Investor in writing of the information the Company requires from each such Investor with respect to such Registration Statement.
It shall be a condition precedent to the obligations of the Company to complete the registration pursuant to this Agreement with
respect to the Registrable Securities of a particular Investor that such Investor shall furnish to the Company such information
regarding itself, the Registrable Securities held by it and the intended method of disposition of the Registrable Securities held
by it, as shall be reasonably required to effect and maintain the effectiveness of the registration of such Registrable Securities
and shall execute such documents in connection with such registration as the Company may reasonably request.

 

(b)
Each Investor, by such Investor’s acceptance of the Registrable Securities, agrees to cooperate with the Company as reasonably
requested by the Company in connection with the preparation and filing of each Registration Statement hereunder, unless such Investor
has notified the Company in writing of such Investor’s election to exclude all of such Investor’s Registrable Securities
from such Registration Statement.

 

    	11

    	 

    

 

(c)
Each Investor agrees that, upon receipt of any notice from the Company of the happening of any event of the kind described in
Section 3(g) or the first sentence of 3(f), such Investor will immediately discontinue disposition of Registrable Securities pursuant
to any Registration Statement(s) covering such Registrable Securities until such Investor’s receipt of the copies of the
supplemented or amended prospectus contemplated by Section 3(g) or the first sentence of Section 3(f) or receipt of notice that
no supplement or amendment is required. Notwithstanding anything to the contrary in this Section 4(c), the Company shall cause
its transfer agent to deliver unlegended shares of Common Stock to a transferee of an Investor in accordance with the terms of
the Securities Purchase Agreement in connection with any sale of Registrable Securities with respect to which such Investor has
entered into a contract for sale prior to the Investor’s receipt of a notice from the Company of the happening of any event
of the kind described in Section 3(g) or the first sentence of Section 3(f) and for which such Investor has not yet settled.

 

(d)
Each Investor covenants and agrees that it will comply with the prospectus delivery requirements of the 1933 Act as applicable
to it in connection with sales of Registrable Securities pursuant to a Registration Statement.

 

5.
Expenses of Registration.

 

All
reasonable expenses, other than underwriting discounts and commissions, incurred in connection with registrations, filings or
qualifications pursuant to Sections 2 and 3, including, without limitation, all registration, listing and qualifications fees,
printers and accounting fees, FINRA filing fees (if any), blue sky fees and fees and disbursements of counsel for the Company
shall be paid by the Company. The Company shall have no obligation to pay the expenses of any Investor incurred in connection
with any registration, filing or qualification pursuant to Sections 2 and 3 of this Agreement.

 

    	12

    	 

    

 

6.
Indemnification.

 

(a)
To the fullest extent permitted by law, the Company will, and hereby does, indemnify, hold harmless and defend each Investor and
each of its directors, officers, shareholders, members, partners, employees, agents, advisors, representatives (and any other
Persons with a functionally equivalent role of a Person holding such titles notwithstanding the lack of such title or any other
title) and each Person, if any, who controls such Investor within the meaning of the 1933 Act or the 1934 Act and each of the
directors, officers, shareholders, members, partners, employees, agents, advisors, representatives (and any other Persons with
a functionally equivalent role of a Person holding such titles notwithstanding the lack of such title or any other title) of such
controlling Persons (each, an “Indemnified Person”), against any losses, obligations, claims, damages, liabilities,
contingencies, judgments, fines, penalties, charges, costs (including, without limitation, court costs, reasonable attorneys’
fees and costs of defense and investigation), amounts paid in settlement or expenses, joint or several, (collectively, “Claims”)
incurred in investigating, preparing or defending any action, claim, suit, inquiry, proceeding, investigation or appeal taken
from the foregoing by or before any court or governmental, administrative or other regulatory agency, body or the SEC, whether
pending or threatened, whether or not an indemnified party is or may be a party thereto (“Indemnified Damages”),
to which any of them may become subject insofar as such Claims (or actions or proceedings, whether commenced or threatened, in
respect thereof) arise out of or are based upon: (i) any untrue statement or alleged untrue statement of a material fact in a
Registration Statement or any post-effective amendment thereto or in any filing made in connection with the qualification of the
offering under the securities or other “blue sky” laws of any jurisdiction in which Registrable Securities are offered
(“Blue Sky Filing”), or the omission or alleged omission to state a material fact required to be stated therein
or necessary to make the statements therein not misleading, (ii) any untrue statement or alleged untrue statement of a material
fact contained in any preliminary prospectus if used prior to the effective date of such Registration Statement, or contained
in the final prospectus (as amended or supplemented, if the Company files any amendment thereof or supplement thereto with the
SEC) or the omission or alleged omission to state therein any material fact necessary to make the statements made therein, in
light of the circumstances under which the statements therein were made, not misleading or (iii) any violation or alleged violation
by the Company of the 1933 Act, the 1934 Act, any other law, including, without limitation, any state securities law, or any rule
or regulation thereunder relating to the offer or sale of the Registrable Securities pursuant to a Registration Statement (the
matters in the foregoing clauses (i) through (iii) being, collectively, “Violations”). Subject to Section 6(c),
the Company shall reimburse the Indemnified Persons, promptly as such expenses are incurred and are due and payable, for any legal
fees or other reasonable expenses incurred by them in connection with investigating or defending any such Claim. Notwithstanding
anything to the contrary contained herein, the indemnification agreement contained in this Section 6(a): (i) shall not apply to
a Claim by an Indemnified Person arising out of or based upon a Violation which occurs in reliance upon and in conformity with
information furnished in writing to the Company by such Indemnified Person for such Indemnified Person expressly for use in connection
with the preparation of such Registration Statement or any such amendment thereof or supplement thereto and (ii) shall not be
available to a particular Investor to the extent such Claim is based on a failure of such Investor to deliver or to cause to be
delivered the prospectus made available by the Company (to the extent applicable), including, without limitation, a corrected
prospectus, if such prospectus or corrected prospectus was timely made available by the Company pursuant to Section 3(d) and then
only if, and to the extent that, following the receipt of the corrected prospectus no grounds for such Claim would have existed;
and (iii) shall not apply to amounts paid in settlement of any Claim if such settlement is effected without the prior written
consent of the Company, which consent shall not be unreasonably withheld or delayed. Such indemnity shall remain in full force
and effect regardless of any investigation made by or on behalf of the Indemnified Person and shall survive the transfer of any
of the Registrable Securities by any of the Investors pursuant to Section 9.

 

(b)
In connection with any Registration Statement in which an Investor is participating, such Investor agrees to severally and not
jointly indemnify, hold harmless and defend, to the same extent and in the same manner as is set forth in Section 6(a), the Company,
each of its directors, each of its officers who signs the Registration Statement and each Person, if any, who controls the Company
within the meaning of the 1933 Act or the 1934 Act (each, an “Indemnified Party”), against any Claim or Indemnified
Damages to which any of them may become subject, under the 1933 Act, the 1934 Act or otherwise, insofar as such Claim or Indemnified
Damages arise out of or are based upon any Violation, in each case, to the extent, and only to the extent, that such Violation
occurs in reliance upon and in conformity with written information furnished to the Company by such Investor expressly for use
in connection with such Registration Statement; and, subject to Section 6(c) and the below provisos in this Section 6(b), such
Investor will reimburse an Indemnified Party any legal or other expenses reasonably incurred by such Indemnified Party in connection
with investigating or defending any such Claim; provided, however, the indemnity agreement contained in this Section 6(b) and
the agreement with respect to contribution contained in Section 7 shall not apply to amounts paid in settlement of any Claim if
such settlement is effected without the prior written consent of such Investor, which consent shall not be unreasonably withheld
or delayed, provided further that such Investor shall be liable under this Section 6(b) for only that amount of a Claim or Indemnified
Damages as does not exceed the net proceeds to such Investor as a result of the applicable sale of Registrable Securities pursuant
to such Registration Statement. Such indemnity shall remain in full force and effect regardless of any investigation made by or
on behalf of such Indemnified Party and shall survive the transfer of any of the Registrable Securities by any of the Investors
pursuant to Section 9.

 

    	13

    	 

    

 

(c)
Promptly after receipt by an Indemnified Person or Indemnified Party (as the case may be) under this Section 6 of notice of the
commencement of any action or proceeding (including, without limitation, any governmental action or proceeding) involving a Claim,
such Indemnified Person or Indemnified Party (as the case may be) shall, if a Claim in respect thereof is to be made against any
indemnifying party under this Section 6, deliver to the indemnifying party a written notice of the commencement thereof, and the
indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly with
any other indemnifying party similarly noticed, to assume control of the defense thereof with counsel mutually satisfactory to
the indemnifying party and the Indemnified Person or the Indemnified Party (as the case may be); provided, however, an Indemnified
Person or Indemnified Party (as the case may be) shall have the right to retain its own counsel with the fees and expenses of
such counsel to be paid by the indemnifying party if: (i) the indemnifying party has agreed in writing to pay such fees and expenses;
(ii) the indemnifying party shall have failed promptly to assume the defense of such Claim and to employ counsel reasonably satisfactory
to such Indemnified Person or Indemnified Party (as the case may be) in any such Claim; or (iii) the named parties to any such
Claim (including, without limitation, any impleaded parties) include both such Indemnified Person or Indemnified Party (as the
case may be) and the indemnifying party, and such Indemnified Person or such Indemnified Party (as the case may be) shall have
been advised by counsel that a conflict of interest is likely to exist if the same counsel were to represent such Indemnified
Person or such Indemnified Party and the indemnifying party (in which case, if such Indemnified Person or such Indemnified Party
(as the case may be) notifies the indemnifying party in writing that it elects to employ separate counsel at the expense of the
indemnifying party, then the indemnifying party shall not have the right to assume the defense thereof and such counsel shall
be at the expense of the Indemnifying Party, provided further that in the case of clause (iii) above the indemnifying party shall
not be responsible for the reasonable fees and expenses of more than one (1) separate legal counsel for such Indemnified Person
or Indemnified Party (as the case may be). The Indemnified Party or Indemnified Person (as the case may be) shall reasonably cooperate
with the indemnifying party in connection with any negotiation or defense of any such action or Claim by the indemnifying party
and shall furnish to the indemnifying party all information reasonably available to the Indemnified Party or Indemnified Person
(as the case may be) which relates to such action or Claim. The indemnifying party shall keep the Indemnified Party or Indemnified
Person (as the case may be) reasonably apprised at all times as to the status of the defense or any settlement negotiations with
respect thereto. No indemnifying party shall be liable for any settlement of any action, claim or proceeding effected without
its prior written consent; provided, however, the indemnifying party shall not unreasonably withhold, delay or condition its consent.
No indemnifying party shall, without the prior written consent of the Indemnified Party or Indemnified Person (as the case may
be), consent to entry of any judgment or enter into any settlement or other compromise which does not include as an unconditional
term thereof the giving by the claimant or plaintiff to such Indemnified Party or Indemnified Person (as the case may be) of a
release from all liability in respect to such Claim or litigation, and such settlement shall not include any admission as to fault
on the part of the Indemnified Party. Following indemnification as provided for hereunder, the indemnifying party shall be subrogated
to all rights of the Indemnified Party or Indemnified Person (as the case may be) with respect to all third parties, firms or
corporations relating to the matter for which indemnification has been made. The failure to deliver written notice to the indemnifying
party within a reasonable time of the commencement of any such action shall not relieve such indemnifying party of any liability
to the Indemnified Person or Indemnified Party (as the case may be) under this Section 6, except to the extent that the indemnifying
party is materially and adversely prejudiced in its ability to defend such action.

 

    	14

    	 

    

 

(d)
No Person involved in the sale of Registrable Securities who is guilty of fraudulent misrepresentation (within the meaning of
Section 11(f) of the 1933 Act) in connection with such sale shall be entitled to indemnification from any Person involved in such
sale of Registrable Securities who is not guilty of fraudulent misrepresentation.

 

(e)
The indemnification required by this Section 6 shall be made by periodic payments of the amount thereof during the course of the
investigation or defense, as and when bills are received or Indemnified Damages are incurred.

 

(f)
The indemnity and contribution agreements contained herein shall be in addition to (i) any cause of action or similar right of
the Indemnified Party or Indemnified Person against the indemnifying party or others, and (ii) any liabilities the indemnifying
party may be subject to pursuant to the law.

 

7.
Contribution.

 

To
the extent any indemnification by an indemnifying party is prohibited or limited by law, the indemnifying party agrees to make
the maximum contribution with respect to any amounts for which it would otherwise be liable under Section 6 to the fullest extent
permitted by law; provided, however: (i) no contribution shall be made under circumstances where the maker would not have been
liable for indemnification under the fault standards set forth in Section 6 of this Agreement, (ii) no Person involved in the
sale of Registrable Securities which Person is guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of
the 1933 Act) in connection with such sale shall be entitled to contribution from any Person involved in such sale of Registrable
Securities who was not guilty of fraudulent misrepresentation; and (iii) contribution by any seller of Registrable Securities
shall be limited in amount to the amount of net proceeds received by such seller from the applicable sale of such Registrable
Securities pursuant to such Registration Statement. Notwithstanding the provisions of this Section 7, no Investor shall be required
to contribute, in the aggregate, any amount in excess of the amount by which the net proceeds actually received by such Investor
from the applicable sale of the Registrable Securities subject to the Claim exceeds the amount of any damages that such Investor
has otherwise been required to pay, or would otherwise be required to pay under Section 6(b), by reason of such untrue or alleged
untrue statement or omission or alleged omission. Notwithstanding the foregoing, the contribution agreement contained in this
Section 7 shall not apply to amounts paid in settlement of any Claim if such settlement is effected without the prior written
consent of the Company, which consent shall not be unreasonably withheld or delayed

 

    	15

    	 

    

 

8.
Reports Under the 1934 Act.

 

With
a view to making available to the Investors the benefits of Rule 144, on and after the Closing Date, the Company agrees to:

 

(a)
make and keep public information available, as those terms are understood and defined in Rule 144;

 

(b)
file with the SEC in a timely manner all reports and other documents required of the Company under the 1933 Act and the 1934 Act
so long as the Company remains subject to such requirements (it being understood and agreed that nothing herein shall limit any
obligations of the Company under the Securities Purchase Agreement) and the filing of such reports and other documents is required
for the applicable provisions of Rule 144; and

 

(c)
furnish to each Investor so long as such Investor owns Registrable Securities, promptly upon request, (i) a written statement
by the Company, if true, that it has complied with the reporting, submission and posting requirements of Rule 144 and the 1934
Act, (ii) a copy of the most recent Form 20-F of the Company and such other reports and documents so filed by the Company with
the SEC if such reports are not publicly available via EDGAR, and (iii) such other information as may be reasonably requested
to permit the Investors to sell such securities pursuant to Rule 144 without registration.

 

9.
Assignment of Registration Rights.

 

The
rights to cause the Company to register Registrable Securities pursuant to this Section 9 may be transferred or assigned, but
only with all related obligations, by an Investor to a transferee or assignee.

 

10.
Amendment of Registration Rights.

 

Provisions
of this Agreement may be amended only with the written consent of the Company and the Required Holders. Any amendment effected
in accordance with this Section 10 shall be binding upon each Investor and the Company, provided that no such amendment shall
be effective to the extent that it (1) applies to less than all of the holders of the holders of Registrable Securities, (2) imposes
any obligation or liability on any Investor without such Investor’s prior written consent (which may be granted or withheld
in such Investor’s sole discretion) or (3) applies retroactively. No waiver shall be effective unless it is in writing and
signed by an authorized representative of the waiving party, provided that the Required Holders (in a writing signed by all of
the Required Holders) may waive any provision of this Agreement, and any waiver of any provision of this Agreement made in conformity
with the provisions of this Section 10 shall be binding on each Investor, provided that no such waiver shall be effective to the
extent that it (1) applies to less than all the Investors (unless a party gives a waiver as to itself only) or (2) imposes any
obligation or liability on any Investor without such Investor’s prior written consent (which may be granted or withheld
in such Investor’s sole discretion). No consideration shall be offered or paid to any Person to amend or consent to a waiver
or modification of any provision of this Agreement unless the same consideration also is offered to all of the parties to this
Agreement.

 

    	16

    	 

    

 

11.
Miscellaneous.

 

(a)
Solely for purposes of this Agreement, a Person is deemed to be a holder of Registrable Securities whenever such Person owns,
or is deemed to own, of record such Registrable Securities. If the Company receives conflicting instructions, notices or elections
from two or more Persons with respect to the same Registrable Securities, the Company shall act upon the basis of instructions,
notice or election received from such record owner of such Registrable Securities.

 

(b)
Any notices, consents, waivers or other communications required or permitted to be given under the terms of this Agreement must
be in writing and will be deemed to have been delivered: (i) upon receipt, when delivered personally; (ii) upon receipt, when
sent by facsimile (provided confirmation of transmission is mechanically or electronically generated and kept on file by the sending
party); (iii) with respect to Section 3(c), by e-mail (provided confirmation of transmission is electronically generated and kept
on file by the sending party); or (iv) one (1) Business Day after deposit with a nationally recognized overnight delivery service
with next day delivery specified, in each case, properly addressed to the party to receive the same. The addresses and facsimile
numbers for such communications shall be:

 

If
to the Company:

 

Pressure
BioSciences, Inc.

14
Norfolk Avenue

South
Easton, Massachusetts 02375

Telephone:

Attention:

 

With
a copy to:

(which
shall not constitute notice)

 

If
to a Buyer, to its address, facsimile number or e-mail address (as the case may be) set forth on the Schedule of Buyers attached
to the Securities Purchase Agreement, with copies to such Buyer’s representatives as set forth on the Schedule of Buyers,
or to such other address, facsimile number and/or e-mail address and/or to the attention of such other Person as the recipient
party has specified by written notice given to each other party five (5) days prior to the effectiveness of such change. Written
confirmation of receipt (A) given by the recipient of such notice, consent, waiver or other communication, (B) mechanically or
electronically generated by the sender’s facsimile machine or e-mail transmission containing the time, date and recipient
facsimile number or e-mail address or (C) provided by a courier or overnight courier service shall be rebuttable evidence of personal
service, receipt by facsimile or receipt from a nationally recognized overnight delivery service in accordance with clause (i),
(ii) or (iii) above, respectively.

 

    	17

    	 

    

 

(c)
Failure of any party to exercise any right or remedy under this Agreement or otherwise, or delay by a party in exercising such
right or remedy, shall not operate as a waiver thereof.

 

(d)
All questions concerning the construction, validity, enforcement and interpretation of this Agreement shall be governed by the
internal laws of the State of New York, without giving effect to any choice of law or conflict of law provision or rule (whether
of the State of New York or any other jurisdictions) that would cause the application of the laws of any jurisdictions other than
the State of New York. Each party hereby irrevocably submits to the exclusive jurisdiction of the state and federal courts sitting
in The City of New York, Borough of Manhattan, for the adjudication of any dispute hereunder or in connection herewith or with
any transaction contemplated hereby or discussed herein, and hereby irrevocably waives, and agrees not to assert in any suit,
action or proceeding, any claim that it is not personally subject to the jurisdiction of any such court, that such suit, action
or proceeding is brought in an inconvenient forum or that the venue of such suit, action or proceeding is improper. Each party
hereby irrevocably waives personal service of process and consents to process being served in any such suit, action or proceeding
by mailing a copy thereof to such party at the address for such notices to it under this Agreement and agrees that such service
shall constitute good and sufficient service of process and notice thereof. Nothing contained herein shall be deemed to limit
in any way any right to serve process in any manner permitted by law. If any provision of this Agreement shall be invalid or unenforceable
in any jurisdiction, such invalidity or unenforceability shall not affect the validity or enforceability of the remainder of this
Agreement in that jurisdiction or the validity or enforceability of any provision of this Agreement in any other jurisdiction.
EACH PARTY HEREBY IRREVOCABLY WAIVES ANY RIGHT IT MAY HAVE TO, AND AGREES NOT TO REQUEST, A JURY TRIAL FOR THE ADJUDICATION OF
ANY DISPUTE HEREUNDER OR IN CONNECTION HEREWITH OR ARISING OUT OF THIS AGREEMENT OR ANY TRANSACTION CONTEMPLATED HEREBY.

 

(e)
This Agreement, the other Transaction Documents, the schedules and exhibits attached hereto and thereto and the instruments referenced
herein and therein constitute the entire agreement among the parties hereto and thereto solely with respect to the subject matter
hereof and thereof. There are no restrictions, promises, warranties or undertakings, other than those set forth or referred to
herein and therein. This Agreement, the other Transaction Documents, the schedules and exhibits attached hereto and thereto and
the instruments referenced herein and therein supersede all prior agreements and understandings among the parties hereto solely
with respect to the subject matter hereof and thereof; provided, however, nothing contained in this Agreement or any other Transaction
Document shall (or shall be deemed to) (i) have any effect on any agreements any Investor has entered into with, or any instrument
that any Investor received from, the Company or any of its Subsidiaries prior to the date hereof with respect to any prior investment
made by such Investor in the Company, (ii) waive, alter, modify or amend in any respect any obligations of the Company or any
of its Subsidiaries or any rights of or benefits to any Investor or any other Person in any agreement entered into prior to the
date hereof between or among the Company and/or any of its Subsidiaries and any Investor or any instrument that any Investor received
prior to the date hereof from the Company and/or any of its Subsidiaries and all such agreements and instruments shall continue
in full force and effect or (iii) limit any obligations of the Company under any of the other Transaction Documents.

 

    	18

    	 

    

 

(f)
Subject to compliance with Section 9 (if applicable), this Agreement shall inure to the benefit of and be binding upon the permitted
successors and assigns of each of the parties hereto. This Agreement is not for the benefit of, nor may any provision hereof be
enforced by, any Person, other than the parties hereto, their respective permitted successors and assigns and the Persons referred
to in Sections 6 and 7 hereof.

 

(g)
The headings in this Agreement are for convenience of reference only and shall not limit or otherwise affect the meaning hereof.
Unless the context clearly indicates otherwise, each pronoun herein shall be deemed to include the masculine, feminine, neuter,
singular and plural forms thereof. The terms “including,” “includes,” “include” and words
of like import shall be construed broadly as if followed by the words “without limitation.” The terms “herein,”
“hereunder,” “hereof” and words of like import refer to this entire Agreement instead of just the provision
in which they are found.

 

(h)
This Agreement may be executed in two or more identical counterparts, all of which shall be considered one and the same agreement
and shall become effective when counterparts have been signed by each party and delivered to the other party. In the event that
any signature is delivered by facsimile transmission or by an e-mail which contains a portable document format (.pdf) file of
an executed signature page, such signature page shall create a valid and binding obligation of the party executing (or on whose
behalf such signature is executed) with the same force and effect as if such signature page were an original thereof.

 

(i)
Each party shall do and perform, or cause to be done and performed, all such further acts and things, and shall execute and deliver
all such other agreements, certificates, instruments and documents as any other party may reasonably request in order to carry
out the intent and accomplish the purposes of this Agreement and the consummation of the transactions contemplated hereby.

 

(j)
The language used in this Agreement will be deemed to be the language chosen by the parties to express their mutual intent and
no rules of strict construction will be applied against any party. Notwithstanding anything to the contrary set forth in Section
10, terms used in this Agreement but defined in the other Transaction Documents shall have the meanings ascribed to such terms
on the Closing Date in such other Transaction Documents unless otherwise consented to in writing by each Investor.

 

(k)
All consents and other determinations required to be made by the Investors pursuant to this Agreement shall be made, unless otherwise
specified in this Agreement, by the Required Holders.

 

    	19

    	 

    

 

(l)
The obligations of each Investor under this Agreement and the other Transaction Documents are several and not joint with the obligations
of any other Investor, and no Investor shall be responsible in any way for the performance of the obligations of any other Investor
under this Agreement or any other Transaction Document. Nothing contained herein or in any other Transaction Document, and no
action taken by any Investor pursuant hereto or thereto, shall be deemed to constitute the Investors as, and the Company acknowledges
that the Investors do not so constitute, a partnership, an association, a joint venture or any other kind of group or entity,
or create a presumption that the Investors are in any way acting in concert or as a group or entity with respect to such obligations
or the transactions contemplated by the Transaction Documents or any matters, and the Company acknowledges that the Investors
are not acting in concert or as a group, and the Company shall not assert any such claim, with respect to such obligations or
the transactions contemplated by this Agreement or any of the other the Transaction Documents. Each Investor shall be entitled
to independently protect and enforce its rights, including, without limitation, the rights arising out of this Agreement or out
of any other Transaction Documents, and it shall not be necessary for any other Investor to be joined as an additional party in
any proceeding for such purpose. The use of a single agreement with respect to the obligations of the Company contained herein
was solely in the control of the Company, not the action or decision of any Investor, and was done solely for the convenience
of the Company and not because it was required or requested to do so by any Investor. It is expressly understood and agreed that
each provision contained in this Agreement and in each other Transaction Document is between the Company and an Investor, solely,
and not between the Company and the Investors collectively and not between and among Investors.

 

[Signature
Pages Follow]

 

    	 	20	 

    	 

    

 

IN
WITNESS WHEREOF, Buyer and the Company have caused their respective signature page to this Registration Rights Agreement to
be duly executed as of December 3, 2019.

 

	 	COMPANY:
	 	 
	 	PRESSURE
    BIOSCIENCES, INC.
	 	 
	 	By:	

	 	Name:	Richard
                                         T. Schumacher

        

	 	Title:	President
                                         and CEO

        

 

    	 

    	 

    

 

IN
WITNESS WHEREOF, Buyer and the Company have caused their respective signature page to this Registration Rights Agreement to
be duly executed as of December 18, 2019.

 

BUYER:

 

Name
of Buyer: __________________________

 

Signature
of Authorized Signatory of Buyer: __________________________

 

Name
of Authorized Signatory: _________________________

 

Title
of Authorized Signatory: __________________________

 

Signature
Page to RRA

 

[SIGNATURE
PAGES CONTINUE]

 

    	 

    	 

    

 

EXHIBIT
A

 

SELLING
STOCKHOLDERS

 

The
shares of Common Stock being offered by the selling stockholders are those shares issued to the selling stockholders and issuable
to the selling stockholders exercise of the warrants or the conversion of the Company’s 10% Senior Secured Convertible Promissory
Notes. For additional information regarding the issuance of the shares of Notes, the shares of Common Stock and the warrants,
see “Private Placement of Notes and Warrants” above. We are registering the shares of Common Stock in order to permit
the selling stockholders to offer the shares for resale from time to time. Except for the ownership of the shares and the warrants
issued pursuant to the Securities Purchase Agreement, the selling stockholders have not had any material relationship with us
within the past three years.

 

The
table below lists the selling stockholders and other information regarding the beneficial ownership (as determined under Section
13(d) of the Securities Exchange Act of 1934, as amended, and the rules and regulations thereunder) of the shares of Common Stock
held by each of the selling stockholders. The second column lists the number of shares of Common Stock beneficially owned by the
selling stockholders, based on their respective ownership as of ________, 2019, assuming exercise of the warrants and the
conversion of the Notes held by each such selling stockholder on that date, but taking account of any limitations on exercise
set forth therein.

 

The
third column lists the shares of Common Stock being offered by this prospectus by the selling stockholders and does not take into
account any limitations on exercise of the warrants or the conversion of the Notes set forth therein.

 

In
accordance with the terms of a registration rights agreement with the holders of the shares of Notes and the warrants, this prospectus
generally covers the resale of (i) the shares and (ii) the maximum number of shares of Common Stock issuable upon exercise of
the warrants and the conversion of the Notes determined as if the outstanding warrants were exercised in full and the Notes were
fully converted (without regard to any limitations on exercise contained therein) as of the trading day immediately preceding
the date this registration statement was initially filed with the SEC. Because the exercise price of the warrants and the conversion
price of the Notes may be adjusted, the number of shares that will actually be issued may be more or less than the number of shares
being offered by this prospectus. The fourth column assumes the sale of all of the shares offered by the selling stockholders
pursuant to this prospectus.

 

Under
the terms of the warrants and the Notes, a selling stockholder may not exercise the warrants or convert the Notes into shares
of Common Stock to the extent (but only to the extent) such selling stockholder or any of its affiliates would beneficially own
a number of shares of our shares of Common Stock which would exceed 4.99%. The number of shares in the second column reflects
these limitations. The selling stockholders may sell all, some or none of their shares in this offering. See “Plan of Distribution.”

 

    	 

    	 

    

 

	 	 	Number
    of shares of 	 	Maximum
    Number of 	 	Number
    of shares of 
	 	 	Common
    Stock	 	shares
    of Common Stock to	 	Common
    Stock
		 	Beneficially
    Owned Prior 	 	be
    Sold Pursuant to this	 	Beneficially
    Owned After
	Name
                                         of Selling Stockholder

                                                         
	 	to
    Offering	 	Prospectus	 	Offering
	 	 	 	 	 	 	 

 

*
Table to be completed based on information provided by the Buyers and their assignees.

 

    	 

    	 

    

 

PLAN
OF DISTRIBUTION

 

We
are registering the shares of Common Stock issued to the holders and issuable upon exercise of the warrants and the conversion
of Notes to permit the resale of these shares of Common Stock by the holders of the shares of the Notes and warrants from time
to time after the date of this prospectus. We will not receive any of the proceeds from the sale by the selling stockholders of
the shares of Common Stock. We will bear all fees and expenses incident to our obligation to register the shares of Common Stock.

 

The
selling stockholders may sell all or a portion of the shares of Common Stock held by them and offered hereby from time to time
directly or through one or more underwriters, broker-dealers or agents. If the shares of Common Stock are sold through underwriters
or broker-dealers, the selling stockholders will be responsible for underwriting discounts or commissions or agent’s commissions.
The shares of Common Stock may be sold in one or more transactions at fixed prices, at prevailing market prices at the time of
the sale, at varying prices determined at the time of sale or at negotiated prices. These sales may be effected in transactions,
which may involve crosses or block transactions, pursuant to one or more of the following methods:

 

	 	●	on
    any national securities exchange or quotation service on which the securities may be listed or quoted at the time of sale;
	 	 	 
	 	●	in
    the over-the-counter market;
	 	 	 
	 	●	in
    transactions otherwise than on these exchanges or systems or in the over-the-counter market;
	 	 	 
	 	●	through
    the writing or settlement of options, whether such options are listed on an options exchange or otherwise;
	 	 	 
	 	●	|ordinary
    brokerage transactions and transactions in which the broker-dealer solicits purchasers;
	 	 	 
	 	●	block
    trades in which the broker-dealer will attempt to sell the shares as agent but may position and resell a portion of the block
    as principal to facilitate the transaction;
	 	 	 
	 	●	purchases
    by a broker-dealer as principal and resale by the broker-dealer for its account;
	 	 	 
	 	●	an
    exchange distribution in accordance with the rules of the applicable exchange;
	 	 	 
	 	●	privately
    negotiated transactions;
	 	 	 
	 	●	short
    sales made after the date the Registration Statement is declared effective by the SEC;
	 	 	 
	 	●	broker-dealers
    may agree with a selling securityholder to sell a specified number of such shares at a stipulated price per share;
	 	 	 
	 	●	a
    combination of any such methods of sale; and
	 	 	 
	 	●	any
    other method permitted pursuant to applicable law.

 

    	 

    	 

    

 

The
selling stockholders may also sell shares of Common Stock under Rule 144 promulgated under the Securities Act of 1933, as amended,
if available, rather than under this prospectus. In addition, the selling stockholders may transfer the shares of Common Stock
by other means not described in this prospectus. If the selling stockholders effect such transactions by selling shares of Common
Stock to or through underwriters, broker-dealers or agents, such underwriters, broker-dealers or agents may receive commissions
in the form of discounts, concessions or commissions from the selling stockholders or commissions from purchasers of the shares
of Common Stock for whom they may act as agent or to whom they may sell as principal (which discounts, concessions or commissions
as to particular underwriters, broker-dealers or agents may be in excess of those customary in the types of transactions involved).
In connection with sales of the shares of Common Stock or otherwise, the selling stockholders may enter into hedging transactions
with broker-dealers, which may in turn engage in short sales of the shares of Common Stock in the course of hedging in positions
they assume. The selling stockholders may also sell shares of Common Stock short and deliver shares of Common Stock covered by
this prospectus to close out short positions and to return borrowed shares in connection with such short sales. The selling stockholders
may also loan or pledge shares of Common Stock to broker-dealers that in turn may sell such shares.

 

The
selling stockholders may pledge or grant a security interest in some or all of the Notes, warrants and shares of Common Stock
owned by them and, if they default in the performance of their secured obligations, the pledgees or secured parties may offer
and sell the shares of Common Stock from time to time pursuant to this prospectus or any amendment to this prospectus under Rule
424(b)(3) or other applicable provision of the Securities Act amending, if necessary, the list of selling stockholders to include
the pledgee, transferee or other successors in interest as selling stockholders under this prospectus. The selling stockholders
also may transfer and donate the shares of Common Stock in other circumstances in which case the transferees, donees, pledgees
or other successors in interest will be the selling beneficial owners for purposes of this prospectus.

 

To
the extent required by the Securities Act and the rules and regulations thereunder, the selling stockholders and any broker-dealer
participating in the distribution of the shares of Common Stock may be deemed to be “underwriters” within the meaning
of the Securities Act, and any commission paid, or any discounts or concessions allowed to, any such broker-dealer may be deemed
to be underwriting commissions or discounts under the Securities Act. At the time a particular offering of the shares of Common
Stock is made, a prospectus supplement, if required, will be distributed, which will set forth the aggregate amount of shares
of Common Stock being offered and the terms of the offering, including the name or names of any broker-dealers or agents, any
discounts, commissions and other terms constituting compensation from the selling stockholders and any discounts, commissions
or concessions allowed or re-allowed or paid to broker-dealers.

 

Under
the securities laws of some states, the shares of Common Stock may be sold in such states only through registered or licensed
brokers or dealers. In addition, in some states the shares of Common Stock may not be sold unless such shares have been registered
or qualified for sale in such state or an exemption from registration or qualification is available and is complied with.

 

There
can be no assurance that any selling stockholder will sell any or all of the shares of Common Stock registered pursuant to the
registration statement, of which this prospectus forms a part.

 

    	 

    	 

    

 

The
selling stockholders and any other person participating in such distribution will be subject to applicable provisions of the Securities
Exchange Act of 1934, as amended, and the rules and regulations thereunder, including, without limitation, to the extent applicable,
Regulation M of the Exchange Act, which may limit the timing of purchases and sales of any of the shares of Common Stock by the
selling stockholders and any other participating person. To the extent applicable, Regulation M may also restrict the ability
of any person engaged in the distribution of the shares of Common Stock to engage in market-making activities with respect to
the shares of Common Stock. All of the foregoing may affect the marketability of the shares of Common Stock and the ability of
any person or entity to engage in market-making activities with respect to the shares of Common Stock.

 

We
will pay all expenses of the registration of the shares of Common Stock pursuant to the registration rights agreement, estimated
to be $[    ] in total, including, without limitation, Securities and Exchange Commission filing fees and expenses of compliance
with state securities or “blue sky” laws; provided, however, a selling stockholder will pay all underwriting discounts
and selling commissions, if any. We will indemnify the selling stockholders against liabilities, including some liabilities under
the Securities Act in accordance with the registration rights agreements or the selling stockholders will be entitled to contribution.
We may be indemnified by the selling stockholders against civil liabilities, including liabilities under the Securities Act that
may arise from any written information furnished to us by the selling stockholder specifically for use in this prospectus, in
accordance with the related registration rights agreements or we may be entitled to contribution.

 

Once
sold under the registration statement, of which this prospectus forms a part, the shares of Common Stock will be freely tradable
in the hands of persons other than our affiliates.

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