Document:

Exhibit 4.2

 

Execution Version

 

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

 

 

TABLE OF CONTENTS

 

	
 
    	
 
    	
Page
    
	
 
    	
 
    	
 
    
	
1.
    	
DEFINITIONS
    	
1
    
	
 
    	
 
    	
 
    
	
2.
    	
REGISTRATION   RIGHTS
    	
6
    
	
 
    	
 
    	
 
    
	
 
    	
2.1.
    	
Demand   Registration
    	
6
    
	
 
    	
2.2.
    	
Company   Registration
    	
7
    
	
 
    	
2.3.
    	
Form S-3   Registration
    	
7
    
	
 
    	
2.4.
    	
Underwriting   Requirements
    	
8
    
	
 
    	
2.5.
    	
Obligations   of the Company
    	
9
    
	
 
    	
2.6.
    	
Furnish   Information
    	
11
    
	
 
    	
2.7.
    	
Expenses   of Registration
    	
11
    
	
 
    	
2.8.
    	
Delay   of Registration
    	
11
    
	
 
    	
2.9.
    	
Indemnification
    	
11
    
	
 
    	
2.10.
    	
Reports   Under Exchange Act
    	
14
    
	
 
    	
2.11.
    	
Limitations   on Subsequent Registration Rights
    	
14
    
	
 
    	
2.12.
    	
“Market   Stand-off” Agreement
    	
15
    
	
 
    	
2.13.
    	
Assignment   of Registration Rights
    	
15
    
	
 
    	
2.14.
    	
Restrictions   on Transfer
    	
16
    
	
 
    	
2.15.
    	
Termination   of Registration Rights
    	
17
    
	
 
    	
 
    	
 
    	
 
    
	
3.
    	
INFORMATION   AND OBSERVER RIGHTS
    	
17
    
	
 
    	
 
    	
 
    
	
 
    	
3.1.
    	
Delivery   of Financial Statements
    	
17
    
	
 
    	
3.2.
    	
Inspection
    	
19
    
	
 
    	
3.3.
    	
Observer   Rights
    	
19
    
	
 
    	
3.4.
    	
Termination   of Information and Observer Rights
    	
19
    
	
 
    	
3.5.
    	
Confidentiality
    	
20
    
	
 
    	
3.6.
    	
Management   Rights Letter
    	
20
    
	
 
    	
 
    	
 
    	
 
    
	
4.
    	
RIGHTS   TO FUTURE STOCK ISSUANCES
    	
20
    
	
 
    	
 
    	
 
    
	
 
    	
4.1.
    	
Right   of First Offer
    	
20
    
	
 
    	
4.2.
    	
Termination
    	
22
    
	
 
    	
 
    	
 
    	
 
    
	
5.
    	
ADDITIONAL   COVENANTS
    	
22
    
	
 
    	
 
    	
 
    
	
 
    	
5.1.
    	
Insurance
    	
22
    
	
 
    	
5.2.
    	
Employee   Agreements
    	
22
    
	
 
    	
5.3.
    	
Employee   Vesting
    	
23
    
	
 
    	
5.4.
    	
Matters   Requiring Preferred Director Approval
    	
23
    
	
 
    	
5.5.
    	
Meetings   of the Board of Directors
    	
24
    
	
 
    	
5.6.
    	
Successor   Indemnification
    	
24
    
	
 
    	
5.7.
    	
Board   Expenses
    	
24
    
	
 
    	
5.8.
    	
Board   Committees
    	
24
    
	
 
    	
5.9.
    	
Termination   of Covenants
    	
24
    
	
 
    	
5.10.
    	
Annual   Review of Science and Technology and Business
    	
25
    

 

i

 

TABLE OF CONTENTS

(continued)

 

	
 
    	
 
    	
Page
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
5.11.
    	
Scientific   Advisory Board
    	
25
    
	
 
    	
 
    	
 
    	
 
    
	
6.
    	
MISCELLANEOUS
    	
25
    
	
 
    	
 
    	
 
    
	
 
    	
6.1.
    	
Successors   and Assigns
    	
25
    
	
 
    	
6.2.
    	
Governing   Law
    	
25
    
	
 
    	
6.3.
    	
Counterparts
    	
25
    
	
 
    	
6.4.
    	
Titles   and Subtitles
    	
25
    
	
 
    	
6.5.
    	
Notices
    	
25
    
	
 
    	
6.6.
    	
Amendments   and Waivers
    	
26
    
	
 
    	
6.7.
    	
Severability
    	
27
    
	
 
    	
6.8.
    	
Aggregation   of Stock
    	
27
    
	
 
    	
6.9.
    	
Additional   Investors
    	
27
    
	
 
    	
6.10.
    	
Entire   Agreement
    	
27
    
	
 
    	
6.11.
    	
Dispute   Resolution
    	
27
    
	
 
    	
6.12.
    	
Delays   or Omissions
    	
28
    
	
 
    	
 
    	
 
    	
 
    
	
Schedule   A
    	
-
    	
Schedule   of Series A Investors
    	
 
    
	
Schedule   B
    	
-
    	
Schedule   of Series A-1 Investors
    	
 
    
	
Schedule   C
    	
-
    	
Schedule   of Series B Investors
    	
 
    
	
Schedule   D
    	
-
    	
Schedule   of Series C Investors
    	
 
    
	
Schedule   E
    	
-
    	
Schedule   of Series D Investors
    	
 
    

 

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FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT

 

THIS FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT (“Agreement”) is made as of the 13th day of May, 2014, by and between Proteon Therapeutics, Inc., a Delaware corporation (the “Company”), each of the investors listed on Schedule A hereto (the “Series A Investors”), each of the investors listed on Schedule B hereto (the “Series A-1 Investors”), each of the investors listed on Schedule C hereto (the “Series B Investors”), each of the investors listed on Schedule D hereto (the “Series C Investors”) and each of the investors listed on Schedule E hereto (the “Series D Investors”), together with any persons or entities that become parties hereto pursuant to Section 6.9 (the Series A Investors, the Series A-1 Investors, the Series B Investors, the Series C Investors, the Series D Investors and such persons or entities, collectively, the “Investors”).

 

RECITALS

 

WHEREAS, the Company and certain of the Investors are parties to an Third Amended and Restated Investor Rights Agreement dated as of August 2, 2011, as previously amended and in effect prior to the date hereof (the “Prior Agreement”);

 

WHEREAS, the Company has entered into a Series D Preferred Stock Purchase Agreement dated as of May 13, 2014 (as amended and in effect from time to time, the “Purchase Agreement”) with the Series D Investors, pursuant to which the Company will issue shares of Series D Preferred Stock (as defined below) to such Series D Investors;

 

WHEREAS, the Series D Investors have made it a condition precedent to their purchase of shares of Series D Preferred Stock pursuant to the Purchase Agreement that the parties enter into this Agreement;

 

WHEREAS, the Company and Series A Investors, Series A-1 Investors, Series B Investors and Series C Investors holding the requisite number of shares of Registrable Securities (as defined in the Prior Agreement) desire to amend and restate the Prior Agreement in the manner provided below; and

 

WHEREAS, in order to induce the Series D Investors to invest funds in the Company pursuant to the Purchase Agreement, the Investors and the Company hereby agree that this Agreement shall govern the rights of the Investors to cause the Company to register shares of Common Stock issuable to the Investors, to receive certain information from the Company, to participate in future equity offerings by the Company and certain other matters as set forth in this Agreement.

 

NOW, THEREFORE, the parties hereby agree as follows:

 

1.                                      Definitions.  For purposes of this Agreement:

 

“Agreement” shall have the meaning set forth in the Preamble.

 

“Affiliate” means, with respect to any specified Person, any other Person who or which, directly or indirectly, controls, is controlled by, or is under common control with such

 

 

specified Person, including without limitation any partner, officer, director, manager or employee of such Person and any venture capital fund now or hereafter existing that is controlled by or under common control with one or more general partners or managing members of, or shares the same management company with, such Person.

 

“Charter” means the Company’s Fifth Amended and Restated Certificate of Incorporation, as amended and in effect from time to time.

 

“Common Stock” means shares of the Company’s common stock, par value $0.001 per share.

 

“Company” shall have the meaning set forth in the Preamble.

 

“Damages” means any loss, claim, damage, or liability (joint or several) to which a party hereto may become subject under the Securities Act, the Exchange Act, or other federal or state law, insofar as such loss, claim, damage, or liability (or any action in respect thereof) arises out of or is based upon (i) any untrue statement or alleged untrue statement of a material fact contained in any registration statement of the Company, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto; (ii) an omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not misleading; or (iii) any violation or alleged violation by any other party hereto of the Securities Act, the Exchange Act, any state securities law, or any rule or regulation promulgated under the Securities Act, the Exchange Act, or any state securities law.

 

“Demand Notice” shall have the meaning set forth in Section 2.1.

 

“Derivative Securities” means any securities or rights convertible into, or exercisable or exchangeable for, Preferred Stock or Common Stock, including options and warrants.

 

“Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated thereunder.

 

“Excluded Registration” means a registration relating either to the sale of securities to employees of the Company pursuant to a stock option, stock purchase, or similar plan or to an SEC Rule 145 transaction; a registration on any form that does not include substantially the same information as would be required to be included in a registration statement covering the sale of the Registrable Securities; or a registration in which the only Common Stock being registered is Common Stock issuable upon conversion of debt securities that are also being registered.

 

“Final Prospectus” shall have the meaning set forth in Section 2.9(d).

 

“Form S-3” means such form under the Securities Act as in effect on the date hereof or any registration form under the Securities Act subsequently adopted by the SEC that permits incorporation of substantial information by reference to other documents filed by the Company with the SEC.

 

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“Fully Exercising Investor” shall have the meaning set forth in Section 4.1(c).

 

“GAAP” means generally accepted accounting principles in the United States.

 

“Holder” means any holder of Registrable Securities who is a party to this Agreement.

 

“Immediate Family Member” means a child, stepchild, grandchild, parent, stepparent, grandparent, spouse, sibling, mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law, or sister-in-law, including adoptive relationships, of a natural person referred to herein.

 

“Initiating Holders” means, collectively, Holders who properly initiate a registration request under this Agreement.

 

“IPO” means the Company’s first underwritten public offering of its Common Stock under the Securities Act.

 

“Investors” shall have the meaning set forth in the Preamble.

 

“Key Person” means Timothy Noyes, Steven Burke, any executive-level employee (including division director and vice president-level positions) and any employee who, either alone or in concert with others, develops, invents, programs, or designs any Company Intellectual Property (as defined in the Purchase Agreement).

 

“Major Holder” means any Investor that, individually or together with such Investor’s Affiliates, holds at least 2,000,000 shares of Registrable Securities (as adjusted for any stock split, stock dividend, combination, or other recapitalization or reclassification effected after the date hereof).

 

“New Securities” means, collectively, equity securities of the Company, whether or not currently authorized, as well as rights, options, or warrants to purchase such equity securities, or securities of any type whatsoever that are, or may become, convertible or exchangeable into or exercisable for such equity securities.

 

“Offer Notice” shall have the meaning set forth in Section 4.1(b).

 

“Person” means any individual, corporation, partnership, trust, limited liability company, association or other entity.

 

“Preferred Director” means each of (i) the directors of the Company that the holders of record of Series D Preferred Stock, exclusively, are entitled to elect, (ii) the director of the Company that the holders of record of Series B Preferred Stock, exclusively, are entitled to elect and (iii) the directors of the Company that the holders of record of Series A Preferred Stock and Series A-1 Preferred Stock, exclusively and voting together as single class, are entitled to elect, in each case pursuant to the Charter.

 

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“Preferred Stock” means, collectively, shares of the Company’s Series A Preferred Stock, Series A-1 Preferred Stock, Series B Preferred Stock, Series C Preferred Stock, and Series D Preferred Stock.

 

“Prior Agreement” shall have the meaning set forth in the Recitals.

 

“Purchase Agreement” shall have the meaning set forth in the Recitals.

 

“Qualified Investors” shall have the meaning set forth in Section 4.1.

 

“Register,” “registered,” and “registration” refer to a registration effected by preparing and filing a registration statement or similar document in compliance with the Securities Act, and the declaration or ordering of effectiveness of such registration statement or document.

 

“Registrable Securities” means (i) the Common Stock issuable or issued upon conversion of the Preferred Stock; (ii) Common Stock issuable or issued pursuant to the Purchase Agreement; (iii) the Warrant Shares; and (iv) any Common Stock issued as (or issuable upon the conversion or exercise of any warrant, right, or other security that is issued as) a dividend or other distribution with respect to, or in exchange for or in replacement of, the shares referenced in clauses (i)-(iii) above; excluding in all cases, however, any Registrable Securities sold by a Person in a transaction in which the rights under Section 2 hereof are not assigned or any shares for which registration rights have terminated pursuant to Section 2.15 of this Agreement.

 

“Registrable Securities then outstanding” means the number of shares of Registrable Securities determined by adding the shares of Common Stock outstanding that are Registrable Securities and the shares of Common Stock issuable pursuant to then exercisable or convertible securities that are Registrable Securities.

 

“Restricted Securities” means the securities of the Company required to bear the legend set forth in Section 2.14(b).

 

“Right of First Refusal and Co-Sale Agreement” means the Fourth Amended and Restated Right of First Refusal and Co-Sale Agreement dated as of the date hereof by and among the Company, the Investors and certain other holders of the Company’s capital stock, as amended and in effect from time to time.

 

“S-3 Notice” shall have the meaning set forth in Section 2.3(a).

 

“SEC” means the Securities and Exchange Commission.

 

“SEC Rule 144” means Rule 144 promulgated by the SEC under the Securities Act.

 

“SEC Rule 145” means Rule 145 promulgated by the SEC under the Securities Act.

 

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“Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.

 

“Selling Expenses” means all underwriting discounts, selling commissions, and stock transfer taxes applicable to the sale of Registrable Securities, and fees and disbursements of one counsel for the Holders, except as provided in Section 2.7.

 

“Series A Investors” shall have the meaning set forth in the Preamble.

 

“Series A Preferred Stock” means shares of the Company’s Series A Preferred Stock, par value $0.001 per share.

 

“Series A-1 Investors” shall have the meaning set forth in the Preamble.

 

“Series A-1 Preferred Stock” means shares of the Company’s Series A-1 Preferred Stock, par value $0.001 per share.

 

“Series B Investors” shall have the meaning set forth in the Preamble.

 

“Series B Preferred Stock” means shares of the Company’s Series B Preferred Stock, par value $0.001 per share.

 

“Series C Investors” shall have the meaning set forth in the Preamble.

 

“Series C Preferred Stock” means shares of the Company’s Series C Preferred Stock, par value $0.001 per share.

 

“Series C Purchase Agreement” means that certain Series C Preferred Stock and Warrant Purchase Agreement, dated as of August 2, 2011, by and among the Company and the Series C Investors, as amended and in effect from time to time.

 

“Series D Investors” shall have the meaning set forth in the Preamble.

 

“Series D Preferred Stock” means shares of the Company’s Series D Preferred Stock, par value $0.001 per share.

 

“Voting Agreement” means the Fourth Amended and Restated Voting Agreement dated as of the date hereof by and among the Company, the Investors and certain other holders of the Company’s capital stock, as amended and in effect from time to time.

 

“Warrants” means the warrants issued to the Series C Investors pursuant to, and in accordance with, the terms and conditions of the Series C Purchase Agreement.

 

“Warrant Shares” means the shares of Common Stock issued or issuable upon the exercise of the Warrants.

 

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2.                                      Registration Rights.  The Company covenants and agrees as follows:

 

2.1.                            Demand Registration.

 

(a)                                 If at any time after the earlier of (i) four (4) years after the date of this Agreement or (ii) one hundred eighty (180) calendar days after the effective date of the registration statement for the IPO, the Company receives a request from Holders of a majority of the Registrable Securities then outstanding that the Company effect a registration with respect to an amount of the Registrable Securities then outstanding, then the Company shall (i) within ten (10) calendar days after the date such request is given, give notice thereof (the “Demand Notice”) to all Holders other than the Initiating Holders; and (ii) as soon as practicable, and in any event within sixty (60) calendar days after the date such request is given by the Initiating Holders, file a registration statement under the Securities Act covering all Registrable Securities that the Initiating Holders requested to be registered and any additional Registrable Securities requested to be included in such registration by any other Holders, as specified by notice given by each such Holder to the Company within twenty (20) calendar days of the date the Demand Notice is given, and in each case, subject to the limitations of Section 2.1(b).

 

(b)                                 Notwithstanding the foregoing obligations, if the Company furnishes to Holders requesting a registration pursuant to this Section 2.1 a certificate signed by the Company’s chief executive officer stating that in the good faith judgment of the Company’s Board of Directors it would be materially detrimental to the Company and its stockholders for such registration statement to either become effective or remain effective for as long as such registration statement otherwise would be required to remain effective, because such action would (i) materially interfere with a significant acquisition, corporate reorganization, or other similar transaction involving the Company; (ii) require premature disclosure of material information that the Company has a bona fide business purpose for preserving as confidential; or (iii) render the Company unable to comply with requirements under the Securities Act or Exchange Act, then the Company shall have the right to defer taking action with respect to such filing, and any time periods with respect to filing or effectiveness thereof shall be tolled correspondingly, for a period of not more than sixty (60) calendar days after the request of the Initiating Holders is given; provided, however, that the Company may not invoke this right more than once in any twelve (12) month period; and provided further that the Company shall not register any securities for its own account or that of any other stockholder during such sixty (60) day period other than pursuant to a registration relating to the sale of securities to employees of the Company pursuant to a stock option, stock purchase, or similar plan; a registration on any form that does not include substantially the same information as would be required to be included in a registration statement covering the sale of the Registrable Securities; or a registration in which the only Common Stock being registered is Common Stock issuable upon conversion of debt securities that are also being registered.

 

(c)                                  The Company shall not be obligated to effect, or to take any action to effect, any registration pursuant to this Section 2.1 (i) during the period that is sixty (60) calendar days before the Company’s good faith estimate of the date of filing of, and ending on a date that is one hundred eighty (180) calendar days after the effective date of, a Company-initiated registration, provided, that the Company is actively employing in good faith commercially reasonable efforts to cause such registration statement to become effective; (ii)

 

6

 

after the Company has effected two registrations; (iii) if the Holders, together with the holders of any other securities of the Company entitled to and requesting inclusion in such registration, propose to sell Registrable Securities and such other securities (if any) at an aggregate price to the public (net of Selling Expenses) of less than $5,000,000; or (iv) if, in a distribution not underwritten, the Initiating Holders propose to dispose of shares of Registrable Securities that may be immediately registered on Form S-3 pursuant to a request made pursuant to Section 2.3.  A registration shall not be counted as “effected” for purposes of this Section 2.1 until such time as the applicable registration statement has been declared effective by the SEC, unless the Initiating Holders withdraw their request for such registration, elect not to pay the registration expenses therefor, and forfeit their right to one demand registration statement pursuant to Section 2.7, in which case such withdrawn registration statement shall be counted as “effected” for purposes of this Section 2.1.

 

2.2.                            Company Registration.  If the Company proposes to register (including, for this purpose, a registration effected by the Company for stockholders other than the Holders) any of its stock or other securities under the Securities Act in connection with the public offering of such securities solely for cash (other than an Excluded Registration), the Company shall, at such time, promptly give each Holder notice of such registration.  Upon the request of each Holder given within twenty (20) calendar days after such notice is given by the Company, the Company shall, subject to the provisions of Section 2.4, cause to be registered all of the Registrable Securities that each such Holder has requested to be included in such registration.  The Company shall have the right to terminate or withdraw any registration initiated by it under this Section 2.2 before the effective date of such registration, whether or not any Holder has elected to include Registrable Securities in such registration.  The expenses of such withdrawn registration shall be borne by the Company in accordance with Section 2.7.

 

2.3.                            Form S-3 Registration.  If the Company receives a request from one or more Holders of the Registrable Securities then outstanding that the Company effect a registration on Form S-3 with respect to all or a part of the Registrable Securities owned by such Initiating Holders, then the Company shall:

 

(a)                                 within ten (10) calendar days after the date such request is given, give notice of the proposed registration to all Holders other than the Initiating Holders (the “S-3 Notice”); and

 

(b)                                 as soon as practicable, use its commercially reasonable efforts to effect such registration as would permit or facilitate the sale and distribution of all or such portion of such Initiating Holders’ Registrable Securities as are specified in such request, together with all or such portion of the Registrable Securities of any other Holders joining in such request as are specified in a request given to the Company within fifteen (15) calendar days after the S-3 Notice is given; provided, however, that the Company shall not be obligated to effect any such registration pursuant to this Section 2.3 (i) if Form S-3 is not then available for such offering by the Holders; (ii) if the Holders, together with the holders of any other securities of the Company entitled to and requesting inclusion in such registration, propose to sell Registrable Securities and such other securities (if any) at an aggregate price to the public (without regard to Selling Expenses) of less than $1,000,000; (iii) if the Company furnishes to the Holders a certificate signed by the chief executive officer of the Company stating that in the

 

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good-faith judgment of the Board of Directors of the Company, it would be materially detrimental to the Company and its stockholders for such Form S-3 registration to be effected at such time, in which event the Company shall have the right to defer the filing of the Form S-3 registration statement for a period of not more than sixty (60) calendar days after receipt of the request of the Initiating Holders under this Section 2.3; provided, however, that the Company shall not invoke this right more than once in any twelve (12) month period; and provided further that the Company shall not register any securities for its own account or that of any other stockholder during such sixty (60) day period other than pursuant to a registration relating to the sale of securities to employees of the Company pursuant to a stock option, stock purchase, or similar plan; a registration on any form that does not include substantially the same information as would be required to be included in a registration statement covering the sale of the Registrable Securities; or a registration in which the only Common Stock being registered is Common Stock issuable upon conversion of debt securities that are also being registered; or (iv) if the Company has, within the twelve (12) month period preceding the date of such request, already effected two registrations on Form S-3 for the Holders pursuant to this Section 2.3; or (v) during the period ending one hundred eighty (180) calendar days after the effective date of a registration made under Section 2.2 hereof.

 

(c)                                  Registrations effected pursuant to this Section 2.3 shall not be counted as demands for registration or registrations effected pursuant to Section 2.1.

 

2.4.                            Underwriting Requirements.

 

(a)                                 If, pursuant to Section 2.1 or Section 2.3, the Initiating Holders intend to distribute the Registrable Securities covered by their request by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to Section 2.1(a) or Section 2.3, and the Company shall include such information in the Demand Notice or the S-3 Notice, as the case may be.  The underwriter will be selected by the Company and shall be reasonably acceptable to a majority in interest of the Initiating Holders.  In such event, the right of any Holder to include such Holder’s Registrable Securities in such registration shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein.  All Holders proposing to distribute their securities through such underwriting shall (together with the Company as provided in Section 2.5(e)) enter into an underwriting agreement in customary form with the underwriter(s) selected for such underwriting.  Notwithstanding any other provision of this Section 2.4, if the underwriter(s) advise(s) the Initiating Holders in writing that marketing factors require a limitation on the number of shares to be underwritten, then the Initiating Holders shall so advise all Holders of Registrable Securities that otherwise would be underwritten pursuant hereto, and the number of Registrable Securities that may be included in the underwriting shall be allocated among all Holders of Registrable Securities, including the Initiating Holders, in proportion (as nearly as practicable) to the number of Registrable Securities of the Company owned by each Holder; provided, however, that the number of Registrable Securities held by the Holders to be included in such underwriting shall not be reduced unless all other securities are first entirely excluded from the underwriting.  To facilitate the allocation of shares in accordance with the above provisions, the Company or the underwriters may round the number of shares allocated to any Holder to the nearest 100 shares.

 

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(b)                                 In connection with any offering involving an underwriting of shares of the Company’s capital stock pursuant to Section 2.2, the Company shall not be required to include any of the Holders’ Registrable Securities in such underwriting unless the Holders accept the terms of the underwriting as agreed upon between the Company and its underwriters, and then only in such quantity as the underwriters in their sole discretion determine will not jeopardize the success of the offering by the Company.  If the total number of securities, including Registrable Securities, requested by stockholders to be included in such offering exceeds the number of securities to be sold (other than by the Company) that the underwriters in their reasonable discretion determine is compatible with the success of the offering, then the Company shall be required to include in the offering only that number of such securities, including Registrable Securities, which the underwriters and the Company in their sole discretion determine will not jeopardize the success of the offering.  In no event shall any Registrable Securities be excluded from such offering unless all other stockholders’ securities have been first excluded.  If the underwriters determine that less than all of the Registrable Securities requested to be registered can be included in such offering, then the Registrable Securities that are included in such offering shall be apportioned pro rata among the selling Holders based on the number of Registrable Securities held by all selling Holders or in such other proportions as shall mutually be agreed to by all such selling Holders.  Notwithstanding the foregoing, in no event shall the number of Registrable Securities included in the offering be reduced below thirty percent (30%) of the total number of securities included in such offering, unless such offering is the IPO, in which case the selling Holders may be excluded further if the underwriters make the determination described above and no other stockholder’s securities are included in such offering.  For purposes of the provision in this Section 2.4(b) concerning apportionment, for any selling stockholder that is a Holder and a partnership, limited liability company, or corporation, the partners, members, retired partners, retired members, stockholders, and Affiliates of such Holder, or the estates and Immediate Family Members of any such partners, retired partners, members, and retired members and any trusts for the benefit of any of the foregoing Persons, shall be deemed to be a single “selling Holder,” and any pro rata reduction with respect to such “selling Holder” shall be based upon the aggregate number of Registrable Securities owned by all Persons included in such “selling Holder,” as defined in this sentence.

 

(c)                                  For purposes of Section 2.1 and Section 2.3, a registration shall not be counted as “effected” if, as a result of an exercise of the underwriter’s cutback provisions in Section 2.4(a), fewer than seventy-five (75%) of the total number of Registrable Securities that Holders have requested to be included in such registration statement are actually included.

 

2.5.                            Obligations of the Company.  Whenever required under this Section 2 to effect the registration of any Registrable Securities, the Company shall, as expeditiously as reasonably possible:

 

(a)                                 prepare and file with the SEC a registration statement with respect to such Registrable Securities and use its commercially reasonable efforts to cause such registration statement to become effective and, upon the request of the Holders of a majority of the Registrable Securities registered thereunder, keep such registration statement effective for a period of up to one hundred twenty (120) calendar days or, if earlier, until the distribution contemplated in the registration statement has been completed; provided, however, that (i) such one hundred twenty (120) calendar day period shall be extended for a period of time equal to the

 

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period the Holder refrains, at the request of an underwriter of Common Stock (or other securities) of the Company, from selling any securities included in such registration, and (ii) in the case of any registration of Registrable Securities on Form S-3 that are intended to be offered on a continuous or delayed basis, subject to compliance with applicable SEC rules, such one hundred twenty (120) calendar day period shall be extended for up to an additional one hundred twenty (120) calendar days, if necessary, to keep the registration statement effective until all such Registrable Securities are sold;

 

(b)                                 prepare and file with the SEC such amendments and supplements to such registration statement, and the prospectus used in connection with such registration statement, as may be necessary to comply with the Securities Act in order to enable the disposition of all securities covered by such registration statement;

 

(c)                                  furnish to the selling Holders such numbers of copies of a prospectus, including a preliminary prospectus, as required by the Securities Act, and such other documents as the Holders may reasonably request in order to facilitate their disposition of their Registrable Securities;

 

(d)                                 use its commercially reasonable efforts to register and qualify the securities covered by such registration statement under such other securities or blue-sky laws of such jurisdictions as shall be reasonably requested by the selling Holders; provided that the Company shall not be required to qualify to do business or to file a general consent to service of process in any such states or jurisdictions, unless the Company is already subject to service in such jurisdiction and except as may be required by the Securities Act;

 

(e)                                  in the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and customary form, with the managing underwriter of such offering;

 

(f)                                   use its commercially reasonable efforts to cause all such Registrable Securities covered by such registration statement to be listed on a national securities exchange or trading system and each securities exchange and trading system (if any) on which similar securities issued by the Company are then listed;

 

(g)                                  provide a transfer agent and registrar for all Registrable Securities registered pursuant to this Agreement and provide a CUSIP number for all such Registrable Securities, in each case not later than the effective date of such registration;

 

(h)                                 promptly make available for inspection by the selling Holders, any  underwriter participating in any disposition pursuant to such registration statement, and any attorney or accountant or other agent retained by any such underwriter or selected by the selling Holders, all financial and other records, pertinent corporate documents, and properties of the Company, and cause the Company’s officers, directors, employees, and independent accountants to supply all information reasonably requested by any such seller, underwriter, attorney, accountant, or agent in connection with any such registration statement;

 

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(i)                                     notify each selling Holder, promptly after the Company receives notice thereof, of the time when such registration statement has been declared effective or a supplement to any prospectus forming a part of such registration statement has been filed; and

 

(j)                                    after such registration statement becomes effective, notify each selling Holder of any request by the SEC that the Company amend or supplement such registration statement or prospectus.

 

2.6.                            Furnish Information.  It shall be a condition precedent to the obligations of the Company to take any action pursuant to this Section 2 with respect to the Registrable Securities of any selling Holder that such Holder shall furnish to the Company such information regarding itself, the Registrable Securities held by it, and the intended method of disposition of such securities as is reasonably required to effect the registration of such Holder’s Registrable Securities.

 

2.7.                            Expenses of Registration.  All expenses (other than Selling Expenses) incurred in connection with registrations, filings, or qualifications pursuant to Section 2, including all registration, filing, and qualification fees; printers’ and accounting fees; fees and disbursements of counsel for the Company; and the reasonable fees and disbursements of one (1) counsel for the selling Holders, shall be borne and paid by the Company; provided, however, that the Company shall not be required to pay for any expenses of any registration proceeding begun pursuant to Section 2.1 or Section 2.3 if the registration request is subsequently withdrawn at the request of the Holders of a majority of the Registrable Securities to be registered (in which case all selling Holders shall bear such expenses pro rata based upon the number of Registrable Securities that were to be included in the withdrawn registration), unless the Holders of a majority of the Registrable Securities agree to forfeit their right to one (1) registration pursuant to Section 2.1 or Section 2.3, as the case may be; provided further that if, at the time of such withdrawal, the Holders have learned of a material adverse change in the condition, business, or prospects of the Company from that known to the Holders at the time of their request and have withdrawn the request with reasonable promptness after learning of such information, then the Holders shall not be required to pay any of such expenses and shall not forfeit their right to one registration pursuant to Section 2.1 or Section 2.3.  All Selling Expenses relating to Registrable Securities registered pursuant to this Section 2 shall be borne and paid by the Holders pro rata on the basis of the number of Registrable Securities registered on their behalf.

 

2.8.                            Delay of Registration.  No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any registration pursuant to this Agreement as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2.

 

2.9.                            Indemnification.  If any Registrable Securities are included in a registration statement under this Section 2:

 

(a)                                 To the extent permitted by law, the Company will indemnify and hold harmless each selling Holder, and the partners, members, officers, directors, and stockholders of each such Holder; legal counsel and accountants for each such Holder; any underwriter (as defined in the Securities Act) for each such Holder; and each Person, if any, who

 

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controls such Holder or underwriter within the meaning of the Securities Act or the Exchange Act, against any Damages, and the Company will pay to each such Holder, underwriter, controlling Person, or other aforementioned Person any legal or other expenses reasonably incurred thereby in connection with investigating any matter or defending any proceeding from which Damages may result, as such expenses are incurred; provided, however, that the indemnity agreement contained in this Section 2.9(a) shall not apply to amounts paid in settlement of any such investigation or proceeding if such settlement is effected without the consent of the Company, which consent shall not be unreasonably withheld, nor shall the Company be liable for any Damages to the extent that they arise out of or are based upon actions or omissions made in reliance upon and in conformity with written information furnished by or on behalf of any such Holder, underwriter, controlling Person, or other aforementioned Person expressly for use in connection with such registration.

 

(b)                                 To the extent permitted by law, each selling Holder, severally and not jointly, will indemnify and hold harmless the Company, and each of its directors, each of its officers who has signed the registration statement, each Person (if any), who controls the Company within the meaning of the Securities Act, legal counsel and accountants for the Company, any underwriter (as defined in the Securities Act), any other Holder selling securities in such registration statement, and any controlling Person of any such underwriter or other Holder, against any Damages, in each case only to the extent that such Damages arise out of or are based upon actions or omissions made in reliance upon and in conformity with written information furnished by or on behalf of such selling Holder expressly for use in connection with such registration; and each such selling Holder will pay to the Company and each other aforementioned Person any legal or other expenses reasonably incurred thereby in connection with investigating any investigation or defending any proceeding from which Damages may result, as such expenses are incurred; provided, however, that the indemnity agreement contained in this Section 2.9(b) shall not apply to amounts paid in settlement of any such investigation or proceeding if such settlement is effected without the consent of the Holder, which consent shall not be unreasonably withheld; and provided further that in no event shall any indemnity under this Section 2.9(b) exceed the proceeds from the offering (net of any Selling Expenses) received by such Holder, except in the case of fraud or willful misconduct by such Holder.

 

(c)                                  Promptly after receipt by an indemnified party under this Section 2.9 of notice of the commencement of any action (including any governmental action) for which a party may be entitled to indemnification hereunder, such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Section 2.9, give the indemnifying party notice of the commencement thereof.  The indemnifying party shall have the right to participate in such action and, to the extent the indemnifying party so desires, participate jointly with any other indemnifying party to which notice has been given, and to assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an indemnified party (together with all other indemnified parties that may be represented without conflict by one counsel) shall have the right to retain one (1) separate counsel, with the fees and expenses to be paid by the indemnifying party, if representation of such indemnified party by the counsel retained by the indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any other party represented by such counsel in such action.  The failure to give notice to the indemnifying party within a reasonable time of the commencement of any such action shall relieve such indemnifying party of any

 

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liability to the indemnified party under this Section 2.9, to the extent that such failure materially prejudices the indemnifying party’s ability to defend such action.  The failure to give notice to the indemnifying party will not relieve it of any liability that it may have to any indemnified party otherwise than under this Section 2.9.

 

(d)                                 The foregoing indemnity agreements of the Company and the selling Holders are subject to the condition that, insofar as they relate to any Damages arising from any untrue statement or alleged untrue statement of a material fact contained in, or omission or alleged omission of a material fact from, a preliminary prospectus (or necessary to make the statements therein not misleading) that has been corrected in the form of prospectus included in the registration statement at the time it becomes effective, or any amendment or supplement thereto filed with the SEC pursuant to Rule 424(b) under the Securities Act (the “Final Prospectus”), such indemnity agreement shall not inure to the benefit of any Person if a copy of the Final Prospectus was furnished to the indemnified party and such indemnified party failed to deliver, at or before the confirmation of the sale of the shares registered in such offering, a copy of the Final Prospectus to the Person asserting the loss, liability, claim, or damage in any case in which such delivery was required by the Securities Act.

 

(e)                                  To provide for just and equitable contribution to joint liability under the Securities Act in any case in which either (i) any party otherwise entitled to indemnification hereunder makes a claim for indemnification pursuant to this Section 2.9 but it is judicially determined (by the entry of a final judgment or decree by a court of competent jurisdiction and the expiration of time to appeal or the denial of the last right of appeal) that such indemnification may not be enforced in such case, notwithstanding the fact that this Section 2.9 provides for indemnification in such case, or (ii) contribution under the Securities Act may be required on the part of any party hereto for which indemnification is provided under this Section 2.9, then, and in each such case, such parties will contribute to the aggregate losses, claims, damages, liabilities, or expenses to which they may be subject (after contribution from others) in such proportion as is appropriate to reflect the relative fault of each of the indemnifying party and the indemnified party in connection with the statements, omissions, or other actions that resulted in such loss, claim, damage, liability, or expense, as well as to reflect any other relevant equitable considerations.  The relative fault of the indemnifying party and of the indemnified party shall be determined by reference to, among other things, whether the untrue or allegedly untrue statement of a material fact, or the omission or alleged omission of a material fact, relates to information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information, and opportunity to correct or prevent such statement or omission; provided, however, that, in any such case, (x) no Holder will be required to contribute any amount in excess of the public offering price of all such Registrable Securities offered and sold by such Holder pursuant to such registration statement, and (y) no Person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) will be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation; and provided further that in no event shall a Holder’s liability pursuant to this Section 2.9(e), when combined with the amounts paid or payable by such Holder pursuant to Section 2.9(b), exceed the proceeds from the offering (net of any Selling Expenses) received by such Holder, except in the case of willful misconduct or fraud by such Holder.

 

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(f)                                   Unless otherwise superseded by an underwriting agreement entered into in connection with the underwritten public offering, the obligations of the Company and Holders under this Section 2.9 shall survive the completion of any offering of Registrable Securities in a registration under this Section 2, and otherwise shall survive the termination of this Agreement.

 

2.10.                     Reports Under Exchange Act.  With a view to making available to the Holders the benefits of SEC Rule 144 and any other rule or regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the public without registration or pursuant to a registration on Form S-3, the Company shall:

 

(a)                                 make and keep public information available, as those terms are understood and defined in SEC Rule 144, at all times after the effective date of the registration statement filed by the Company for the IPO;

 

(b)                                 use commercially reasonable efforts to file with the SEC in a timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act (at any time after the Company has become subject to such reporting requirements); and

 

(c)                                  furnish to any Holder, so long as the Holder owns any Registrable Securities, forthwith upon request (i) a written statement by the Company that it has complied with the reporting requirements of SEC Rule 144 (at any time after ninety (90) calendar days after the effective date of the registration statement filed by the Company for the IPO), the Securities Act, and the Exchange Act (at any time after the Company has become subject to such reporting requirements), or that it qualifies as a registrant whose securities may be resold pursuant to Form S-3 (at any time after the Company so qualifies); (ii) a copy of the most recent annual or quarterly report of the Company and such other reports and documents so filed by the Company; and (iii) such other information as may be reasonably requested in availing any Holder of any rule or regulation of the SEC that permits the selling of any such securities without registration (at any time after the Company has become subject to the reporting requirements under the Exchange Act) or pursuant to such Form S-3 (at any time after the Company so qualifies to use such form).

 

2.11.                     Limitations on Subsequent Registration Rights.  From and after the date of this Agreement, the Company shall not, without the prior written consent of the Holders of at least seventy percent (70%) of the Registrable Securities then-outstanding and the holders of at least a majority of Registrable Securities issued or issuable upon conversion of the Series D Preferred Stock then-outstanding, enter into any agreement with any holder or prospective holder of any securities of the Company that would allow such holder or prospective holder (i) to include such securities in any registration unless, under the terms of such agreement, such holder or prospective holder may include such securities in any such registration only to the extent that the inclusion of such securities will not reduce the number of the Registrable Securities of the Holders that are included or (ii) to demand registration of any securities held by such holder or prospective holder; provided that this limitation shall not apply to any additional Holder who becomes a party to this Agreement in accordance with Section 6.9.

 

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2.12.                     “Market Stand-off” Agreement.  Each Holder hereby agrees that it will not, if such a request is made in writing by the managing underwriter, during the period commencing on the date of the final prospectus relating to the IPO and ending on the date specified by the Company and the managing underwriter (such period not to exceed one hundred eighty (180) calendar days) (i) lend; offer; pledge; sell; contract to sell; sell any option or contract to purchase; purchase any option or contract to sell; grant any option, right, or warrant to purchase; or otherwise transfer or dispose of, directly or indirectly, any shares of Common Stock or any securities convertible into or exercisable or exchangeable for Common Stock (whether such shares or any such securities are then owned by the Holder or are thereafter acquired); or (ii) enter into any swap or other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of the Common Stock, whether any such transaction described in clause (i) or (ii) above is to be settled by delivery of Common Stock or other securities, in cash, or otherwise.  The foregoing provisions of this Section 2.12 shall apply only to the IPO, shall not apply to the sale of any shares to an underwriter pursuant to an underwriting agreement, shall not apply to any shares issued under the Purchase Agreement after the closing of the IPO, shall not apply to any shares purchased by a Holder in the IPO, and shall be applicable to the Holders only if all officers, all directors, and all stockholders individually owning more than one percent (1%) of the Company’s outstanding Common Stock are subject to the same restrictions.  The underwriters in connection with the IPO are intended third-party beneficiaries of this Section 2.12 and shall have the right, power, and authority to enforce the provisions hereof as though they were a party hereto.  Each Holder further agrees to execute such agreements as may be reasonably requested by the underwriters in the IPO that are consistent with this Section 2.12 or that are necessary to give further effect thereto.  Any discretionary waiver or termination of the restrictions of any or all of such agreements by the Company or the underwriters shall apply pro rata to all Major Holders subject to such agreements, based on the number of shares held.

 

2.13.                     Assignment of Registration Rights.  The rights to cause the Company to register Registrable Securities pursuant to this Section 2 may be assigned (but only with all related obligations) by a Holder to a transferee of such Registrable Securities that (i) is an Affiliate, partner, member, limited partner, retired partner, retired member, or stockholder of a Holder; (ii) is a Holder’s Immediate Family Member or trust for the benefit of an individual Holder or one or more of such Holder’s Immediate Family Members; or (iii) after such transfer, holds at least 500,000 shares of Registrable Securities (subject to appropriate adjustment for stock splits, stock dividends, combinations, and other recapitalizations); provided, however, that (x) the Company is, within a reasonable time after such transfer, furnished with written notice of the name and address of such transferee and the Registrable Securities with respect to which such registration rights are being transferred; and (y) such transferee agrees in writing to be bound by and subject to the terms and conditions of this Agreement, including the provisions of Section 2.12.  For the purposes of determining the number of shares of Registrable Securities held by a transferee, the holdings of a transferee (1) that is an Affiliate, limited partner, retired partner, member, retired member, or stockholder of a Holder; (2) who is a Holder’s Immediate Family Member; or (3) that is a trust for the benefit of an individual Holder or such Holder’s Immediate Family Member shall be aggregated together and with those of the transferring Holder; provided further that all transferees who would not qualify individually for assignment of registration rights shall have a single attorney-in-fact for the purpose of exercising any rights, receiving notices, or taking any action under this Section 2.

 

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2.14.                     Restrictions on Transfer.

 

(a)                                 The Preferred Stock and the Registrable Securities shall not be sold, pledged, or otherwise transferred, and the Company shall not recognize any such sale, pledge, or transfer, except upon the conditions specified in (i) the Right of First Refusal and Co-Sale Agreement; and (ii) this Agreement, which conditions are intended, among other things, to ensure compliance with the provisions of the Securities Act.  A transferring Holder will cause any proposed purchaser, pledgee, or transferee of the Preferred Stock and the Registrable Securities held by such Holder to agree to take and hold such securities subject to the provisions and upon the conditions specified in the Right of First Refusal and Co-Sale Agreement and this Agreement.

 

(b)                                 Each certificate representing (i) the Preferred Stock, (ii) the Registrable Securities, and (iii) any other securities issued in respect of the securities referenced in clauses (i) and (ii), upon any stock split, stock dividend, recapitalization, merger, consolidation, or similar event, shall (unless otherwise permitted by the provisions of Section 2.14(c)) be stamped or otherwise imprinted with a legend in the following form:

 

THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF.  NO SUCH TRANSFER MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933.

 

THE SHARES REPRESENTED BY THIS CERTIFICATE MAY BE TRANSFERRED ONLY IN ACCORDANCE WITH THE TERMS OF A CERTAIN INVESTORS’ RIGHTS AGREEMENT BETWEEN THE COMPANY AND THE STOCKHOLDER, A COPY OF WHICH IS ON FILE WITH THE SECRETARY OF THE COMPANY.

 

The Holders consent to the Company making a notation in its records and giving instructions to any transfer agent of the Restricted Securities in order to implement the restrictions on transfer set forth in this Section 2.14.

 

(c)                                  The holder of each certificate representing Restricted Securities, by acceptance thereof, agrees to comply in all respects with the provisions of this Section 2.  Before any proposed sale, pledge, or transfer of any Restricted Securities, unless there is in effect a registration statement under the Securities Act covering the proposed transaction, the Holder thereof shall give notice to the Company of such Holder’s intention to effect such sale, pledge, or transfer.  Each such notice shall describe the manner and circumstances of the proposed sale, pledge, or transfer in sufficient detail and, if reasonably requested by the Company, shall be accompanied at such Holder’s expense by either (i) a written opinion of legal counsel who shall, and whose legal opinion shall, be reasonably satisfactory to the Company, addressed to the

 

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Company, to the effect that the proposed transaction may be effected without registration under the Securities Act; (ii) a “no action” letter from the SEC to the effect that the proposed  sale, pledge, or transfer of such Restricted Securities without registration will not result in a recommendation by the staff of the SEC that action be taken with respect thereto; or (iii) any other evidence reasonably satisfactory to counsel to the Company to the effect that the proposed sale, pledge, or transfer of the Restricted Securities may be effected without registration under the Securities Act, whereupon the Holder of such Restricted Securities shall be entitled to sell, pledge, or transfer such Restricted Securities in accordance with the terms of the notice given by the Holder to the Company.  The Company will not require such a legal opinion or “no action” letter (x) in any transaction in compliance with Rule 144 or (y) in any transaction in which such Holder distributes Restricted Securities to an Affiliate of such Holder for no consideration; provided that each transferee agrees in writing to be subject to the terms of this Section 2.14(c).  Each certificate evidencing the Restricted Securities transferred as above provided shall bear, except if such transfer is made pursuant to Rule 144, the appropriate restrictive legend set forth in Section 2.14(b), except that such certificate shall not bear such restrictive legend if, in the opinion of counsel for such Holder and the Company, such legend is not required in order to establish compliance with any provisions of the Securities Act.

 

2.15.                     Termination of Registration Rights.  The right of any Holder to request registration or inclusion of Registrable Securities in any registration pursuant to Section 2.1, Section 2.2, or Section 2.3 shall terminate upon the earlier of:

 

(a)                                 the closing of a Deemed Liquidation Event, as such term is defined in the Charter; or

 

(b)                                 such time as all of such Holder’s Registrable Securities constitute less than three percent (3%) of the outstanding Common Stock and could be sold without restriction under SEC Rule 144.

 

3.                                      Information and Observer Rights.

 

3.1.                            Delivery of Financial Statements.  The Company shall deliver to each Major Holder:

 

(a)                                 as soon as practicable, but in any event within one hundred eighty (180) calendar days after the end of each fiscal year of the Company, (i) a balance sheet as of the end of such year; (ii) statements of income and of cash flows for such year; and (iii) a statement of stockholders’ equity as of the end of such year, audited and certified by independent public accountants of a “Big Four” accounting firm or an accounting firm approved by the audit committee;

 

(b)                                 as soon as practicable, but in any event within forty five (45) calendar days after the end of each of the first three (3) quarters of each fiscal year of the Company, unaudited statements of income and of cash flows for such fiscal quarter, and an unaudited balance sheet as of the end of such fiscal quarter, all prepared in accordance with GAAP (except that the financial report may (i) be subject to normal year-end audit adjustments and (ii) not contain all notes thereto that may be required in accordance with GAAP);

 

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(c)                                  as soon as practicable, but in any event within forty-five (45) calendar days after the end of each quarter of each fiscal year of the Company, a statement showing the number of shares of each class and series of capital stock and securities convertible into or exercisable for shares of capital stock outstanding at the end of the period, the Common Stock issuable upon conversion or exercise of any outstanding securities convertible or exercisable for Common Stock and the exchange ratio or exercise price applicable thereto, and the number of shares of issued stock options and stock options not yet issued but reserved for issuance, if any, all in sufficient detail as to permit the Major Holders to calculate their respective percentage equity ownership in the Company, and certified by the chief financial officer or chief executive officer of the Company as being true, complete, and correct;

 

(d)                                 as soon as practicable, but in any event within forty-five (45) calendar days of the end of each month, an unaudited income statement and statement of cash flows for such month, and an unaudited balance sheet as of the end of such month, all prepared in accordance with GAAP (except that the financial report may (i) be subject to normal year-end audit adjustments and (ii) not contain all notes thereto that may be required in accordance with GAAP);

 

(e)                                  as soon as practicable, but in any event thirty (30) calendar days before the end of each fiscal year, a budget and business plan for the next fiscal year (collectively, the “Budget”), prepared on a monthly basis, including balance sheets, income statements, and statements of cash flow for such months and, promptly after prepared, any other budgets or revised budgets prepared by the Company;

 

(f)                                   at the request of any Major Holder, as soon as practicable following the end of each fiscal year, an annual business plan and a management report covering all major events;

 

(g)                                  with respect to the financial statements called for in Section 3.1(b) and Section 3.1(d), an instrument executed by the chief financial officer and chief executive officer of the Company certifying on behalf of the Company that such financial statements were prepared in accordance with GAAP consistently applied with prior practice for earlier periods (except as otherwise set forth in Section 3.1(b) and Section 3.1(d)) and fairly present the financial condition of the Company and its results of operation as of and for the periods specified therein; and

 

(h)                                 such other information relating to the financial condition, business, prospects, or corporate affairs of the Company as any Major Holder may from time to time reasonably request; provided, however, that the Company shall not be obligated under this Section 3.1 to provide information (i) that the Company reasonably determines in good faith to be a trade secret or confidential information (unless covered by an enforceable confidentiality agreement, in form acceptable to the Company) or (ii) the disclosure of which would adversely affect the attorney-client privilege between the Company and its counsel.

 

If, for any period, the Company has any subsidiary whose accounts are consolidated with those of the Company, then in respect of such period the financial statements delivered pursuant to the

 

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foregoing sections shall be the consolidated and consolidating financial statements of the Company and all such consolidated subsidiaries.

 

Notwithstanding anything else in this Section 3.1 to the contrary, the Company may cease providing the information set forth in this Section 3.1 during the period starting with the date sixty (60) calendar days before the Company’s good-faith estimate of the date of filing a registration statement for an IPO; provided that the Company’s covenants under this Section 3.1 shall be reinstated at such time as the Company is no longer actively employing its commercially reasonable efforts to cause such registration statement to become effective.

 

3.2.                            Inspection.  The Company shall permit each Major Holder, at such Major Holder’s expense, to visit and inspect the Company’s properties; examine its books of account and records; and discuss the Company’s affairs, finances, and accounts with its officers, during normal business hours of the Company as may be reasonably requested by the Major Holder upon reasonable advance notice; provided, however, that the Company shall not be obligated pursuant to this Section 3.2 to provide access to any information that it reasonably considers to be a trade secret or confidential information (unless covered by an enforceable confidentiality agreement, in form acceptable to the Company) or the disclosure of which would adversely affect the attorney-client privilege between the Company and its counsel.

 

3.3.                            Observer Rights.  Devon Park Bioventures, L.P., Bessemer Venture Partners VII L.P., MPM Bio IV NVS Strategic Fund, LP, TVM Life Science Ventures VI, L.P., Skyline Venture Partners Qualified Purchaser Fund IV, L.P., Prism Venture Partners V, L.P., Intersouth Partners VI, L.P., Deerfield Private Design Fund III, L.P., Abingworth Bioventures VI LP, Pharmstandard International S.A., and the holders of a majority of the outstanding shares of capital stock held by the Key Holders (as defined in the Voting Agreement) shall each be entitled to designate one person to attend all meetings of the Company’s Board of Directors in a nonvoting observer capacity and, in this respect, the Company shall give such designees copies of all notices, minutes, consents, and other materials that it provides to its directors at the same time and in the same manner as provided to such directors; provided, however, that each such designee shall agree to hold in confidence and trust and to act in a fiduciary manner with respect to all information so provided; and provided further, that the Company reserves the right to withhold any information and to exclude any such designee from any meeting or portion thereof if access to such information or attendance at such meeting could adversely affect the attorney-client privilege between the Company and its counsel or result in disclosure of trade secrets or a conflict of interest.  The right of the holders of a majority of the outstanding shares of capital stock held by the Key Holders to designate a Board observer under this section shall terminate on the date on which the Key Holders, as of the effective date of this Agreement, hold collectively less than five percent (5%) of the total issued and outstanding voting capital stock of the Company.

 

3.4.                            Termination of Information and Observer Rights.

 

(a)                                 The covenants set forth in Section 3.1, Section 3.2 and Section 3.3 shall terminate and be of no further force or effect (i) immediately before the consummation of the IPO, (ii) when the Company first becomes subject to the periodic reporting requirements of

 

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Section 12(g) or 15(d) of the Exchange Act, or (iii) upon a Deemed Liquidation Event, as such term is defined in the Charter, whichever event occurs first.

 

(b)                                 The rights, if any, of an Investor under Section 3.3 shall terminate on the date on which such Investor’s shares of Series D Preferred Stock are converted to Common Stock pursuant to Section 5A of Division C of Article Fourth of the Charter.  The rights, if any, of an Investor granted under any written agreement with the Company to designate one or more persons to attend all meetings of the Company’s Board of Directors in a nonvoting observer capacity shall terminate on the date on which such Investor’s shares of Series D Preferred Stock are converted to Common Stock pursuant to Section 5A of Division C of Article Fourth of the Charter.

 

(c)                                  The covenants set forth in Section 3.1 (excluding Section 3.1(a)) and Section 3.2 with respect to an Investor shall terminate and be of no further force or effect with respect to such Investor on the date on which such Investor’s shares of Series D Preferred Stock are converted to Common Stock pursuant to Section 5A of Division C of Article Fourth of the Charter.

 

3.5.                            Confidentiality.  Each Investor agrees that such Investor will keep confidential and will not disclose, divulge, or use for any purpose (other than to monitor its investment in the Company) any confidential information obtained from the Company pursuant to the terms of this Agreement (including notice of the Company’s intention to file a registration statement), unless such confidential information (a) is known or becomes known to the public in general (other than as a result of a breach of this Section 3.5 by such Investor), (b) is or has been independently developed or conceived by the Investor without use of the Company’s confidential information, or (c) is or has been made known or disclosed to the Investor by a third party without a breach of any obligation of confidentiality such third party may have to the Company; provided, however, that an Investor may disclose confidential information (i) to its attorneys, accountants, consultants, and other professionals to the extent necessary to obtain their services in connection with monitoring its investment in the Company; (ii) to any prospective purchaser of any Registrable Securities from such Investor, if such prospective purchaser agrees to be bound by the provisions of this Section 3.5; (iii) to any Affiliate, partner, member, stockholder, or wholly owned subsidiary of such Investor in the ordinary course of business, provided that such Investor informs such Person that such information is confidential and directs such Person to maintain the confidentiality of such information; or (iv) as may otherwise be required by law, provided that the Investor promptly notifies the Company of such disclosure and takes reasonable steps to minimize the extent of any such required disclosure.  The Company acknowledges that certain of the Investors are in the business of venture capital investing and therefore review the business plans and related proprietary information of many enterprises, including enterprises that may have products or services that compete directly or indirectly with those of the Company.  The Company further acknowledges that certain of the Investors may engage in the research, development or commercialization of products or services that compete directly or indirectly with those of the Company. Nothing in this Agreement shall preclude or in any way restrict the Investors from investing or participating in any particular enterprise, or from engaging in such research, development or commercialization activities, regardless of whether such enterprise or activities are competitive with respect to the Company, so long as such activities do not result in a violation of the confidentiality provisions of this Agreement.

 

20

 

3.6.                            Management Rights Letter.  At Closing under and as defined in the Purchase Agreement, the Company shall deliver to each Investor that participates in such Closing and who makes such a request, a Management Rights Letter (as defined in the Purchase Agreement) in a form reasonably acceptable to the Investors.

 

4.                                      Rights to Future Stock Issuances.

 

4.1.                            Right of First Offer.

 

(a)                                 Subject to the terms and conditions of this Section 4.1 and applicable securities laws, if the Company proposes to offer or sell any New Securities, the Company shall first offer such New Securities to each Investor: (i) that holds at least 150,000 shares of Preferred Stock (subject to appropriate adjustment for stock splits, stock dividends, combinations, and other recapitalizations); and (ii) which is an “Accredited Investor” as defined in Rule 501 under the Securities Act (“Qualified Investors”).  A Qualified Investor shall be entitled to apportion the right of first offer hereby granted to it among itself and its Affiliates in such proportions as it deems appropriate.”

 

(b)                                 The Company shall give notice (the “Offer Notice”) to each Qualified Investor, stating (i) its bona fide intention to offer such New Securities, (ii) the number of such New Securities to be offered, and (iii) the price and terms, if any, upon which it proposes to offer such New Securities.

 

(c)                                  By notification to the Company within twenty (20) calendar days after the Offer Notice is given, each Qualified Investor may elect to purchase or otherwise acquire, at the price and on the terms specified in the Offer Notice, up to that portion of such New Securities which equals the proportion that the Common Stock issued and held, or issuable upon conversion of the Preferred Stock and any other Derivative Securities then held, by such Qualified Investor bears to the total Common Stock of the Company then outstanding (assuming full conversion and exercise of all Derivative Securities).  At the expiration of such twenty (20) day period, the Company shall promptly notify each Qualified Investor that elects to purchase or acquire all the shares available to it (each, a “Fully Exercising Investor”) of any other Qualified Investor’s failure to do likewise.  During the ten (10) day period commencing after the Company has given such notice, each Fully Exercising Investor may, by giving notice to the Company, elect to purchase or acquire, in addition to the number of shares specified above, up to that portion of the New Securities for which Qualified Investors were entitled to subscribe but that were not subscribed for by the Qualified Investors which is equal to the proportion that the Common Stock issued and held, or issuable upon conversion of Preferred Stock then held, by such Fully Exercising Investor bears to the Common Stock issued and held, or issuable upon conversion of the Preferred Stock then held, by all Fully Exercising Investors who wish to purchase such unsubscribed shares.  The closing of any sale pursuant to this Section 4.1(c) shall occur within sixty (60) calendar days of the date that the Offer Notice is given.

 

(d)                                 If all New Securities referred to in the Offer Notice are not elected to be purchased or acquired as provided in Section 4.1(c)the Company may, during the ninety (90) day period following the expiration of the periods provided in Section 4.1(c)offer and sell the remaining unsubscribed portion of such New Securities to any Person or Persons at a price

 

21

 

not less than, and upon terms no more favorable to the offeree than, those specified in the Offer Notice.  If the Company does not enter into an agreement for the sale of the New Securities within such period, or if such agreement is not consummated within thirty (30) calendar days of the execution thereof, the right provided hereunder shall be deemed to be revived and such New Securities shall not be offered unless first reoffered to the Qualified Investors in accordance with this Section 4.1.

 

(e)                                  The right of first offer in this Section 4.1 shall not be applicable to (i) shares of Common Stock or Derivative Securities issued as a dividend or distribution on Preferred Stock; (ii) shares of Common Stock or Derivative Securities issued by reason of a dividend, stock split, split-up or other distribution on shares of Common Stock that is covered by the Charter Article Fourth Part C Sections 4.5, 4.6, 4.7 or 4.8; (iii) shares of Common Stock or Derivative Securities issued to employees or directors of, or consultants or advisors to, the Company or any of its subsidiaries pursuant to a plan, agreement or arrangement approved by the Board of Directors of the Company; (iv) shares of Common Stock or Derivative Securities actually issued upon the exercise of Derivative Securities or shares of Common Stock actually issued upon the conversion or exchange of Derivative Securities, in each case provided such issuance is pursuant to the terms of such Derivative Security; (v) shares of Common Stock or Derivative Securities issued to banks, equipment lessors or other financial institutions, or to real property lessors, pursuant to a debt financing, equipment leasing or real property leasing transaction approved by the Board of Directors of the Company including a majority of the Preferred Directors; (vi) shares of Common Stock or Derivative Securities issued or issuable to a contracting party in connection with a licensing, corporate partnering, merger, acquisition or similar strategic or combination transaction approved by a majority of the Board of Directors of the Company, including a majority of the Preferred Directors; (vii) the Warrants and/or shares of Common Stock issued or issuable upon exercise of the Warrants; or (viii) shares of Series D Preferred Stock or Common Stock issued or issuable pursuant to the Purchase Agreement (including, without limitation, any right granted under the Purchase Agreement to purchase shares of Series D Preferred Stock or Common Stock) and/or shares of Common Stock issued or issuable upon conversion of such shares of Series D Preferred Stock.

 

4.2.                            Termination.  The covenants set forth in Section 4.1 shall terminate and be of no further force or effect immediately before the consummation of the IPO.  The covenants set forth in Section 4.1 shall terminate and be of no further force and effect upon a Deemed Liquidation Event, as such term is defined in the Charter.  The covenants set forth in Section 4.1 with respect to an Investor shall terminate with respect to such Investor on the date on which such Investor’s shares of Series D Preferred Stock are converted to Common Stock pursuant to Section 5A of Division C of Article Fourth of the Charter.

 

5.                                      Additional Covenants.

 

5.1.                            Insurance.  The Company shall use its commercially reasonable efforts to obtain, to the extent it has not already done so, within ninety (90) calendar days of the date hereof, from financially sound and reputable insurers Directors and Officers Errors and Omissions insurance in an amount satisfactory to the Board of Directors, and will use commercially reasonable efforts to cause such insurance policies to be maintained until such time as the Board of Directors determines that such insurance should be discontinued.

 

22

 

5.2.                            Employee Agreements.  The Company will cause (i) each Person now or hereafter employed by it or by any subsidiary (or engaged by the Company or any subsidiary as a consultant/independent contractor) with access to confidential information and/or trade secrets, or who works on technical matters, to enter into a nondisclosure and proprietary rights assignment agreement which provides, among other things, for the protection of confidential information of the Company and the assignment to and ownership by the Company of patents, patent applications, and other intellectual property rights conceived of or developed during such Person’s employment with the Company and (ii) each Key Person to enter into a non-competition and nonsolicitation agreement, in a form acceptable to the Major Holders, which provides that such Key Person will not compete with the Company or solicit employees of the Company while employed and for a period of one (1) year following termination of such Key Person’s employment.  In addition, the Company shall not amend, modify, terminate, waive, or otherwise alter, in whole or in part, any of the above-referenced agreements or any restricted stock agreement between the Company and any employee, without the unanimous consent of the Preferred Directors.

 

5.3.                            Employee Vesting.  Unless otherwise approved by the Board of Directors, all future employees and consultants of the Company who purchase, receive options to purchase, or receive awards of shares of the Company’s capital stock after the date hereof shall be required to execute restricted stock or option agreements, as applicable, providing for (i) vesting of shares over a four (4) year period, with the first twenty-five percent (25%) of such shares vesting following twelve (12) months of continued employment or service, and the remaining shares vesting in equal quarterly installments over the following twelve (12) quarters, and (ii) a one hundred eighty (180) day lockup period in connection with the IPO.  The Company shall retain a “right of first refusal” on employee transfers until the Company’s IPO and shall have the right to repurchase unvested shares at cost upon termination of employment of a holder of restricted stock.

 

5.4.                            Matters Requiring Preferred Director Approval.  So long as at least 10% of the shares of Preferred Stock issued as of the date hereof remain outstanding, the Company hereby covenants and agrees with each of the Investors that it shall not, without approval of the Board of Directors, which approval must include the affirmative vote of a majority of the Preferred Directors:

 

(a)                                 make, or permit any subsidiary to make, any loan or advance to, or own any stock or other securities of, any subsidiary or other corporation, partnership, or other entity unless it is wholly owned by the Company;

 

(b)                                 make, or permit any subsidiary to make, any loan or advance to any Person, including, without limitation, any employee or director of the Company or any subsidiary, except advances and similar expenditures in the ordinary course of business or under the terms of an employee stock or option plan approved by the Board of Directors;

 

(c)                                  guarantee, directly or indirectly, or permit any subsidiary to guarantee, directly or indirectly, any indebtedness except for trade accounts of the Company or any subsidiary arising in the ordinary course of business;

 

23

 

(d)                                 make any investment other than investments in prime commercial paper, money market funds, certificates of deposit in any United States bank having a net worth in excess of $100,000,000 or obligations issued or guaranteed by the United States of America, in each case having a maturity not in excess of two (2) years;

 

(e)                                  incur any aggregate indebtedness in excess of $1,000,000 that is not already included in a budget approved or modified by the Board of Directors, other than trade credit incurred in the ordinary course of business;

 

(f)                                   otherwise enter into or be a party to any transaction with any director, officer, or employee of the Company or any “associate” (as defined in Rule 12b-2 promulgated under the Exchange Act) of any such Person, except for transactions contemplated by this Agreement, the Purchase Agreement, or transactions made in the ordinary course of business and pursuant to reasonable requirements of the Company’s business and upon fair and reasonable terms;

 

(g)                                  hire, terminate, or change the compensation of the executive officers, including approving any option grants or stock awards to executive officers;

 

(h)                                 change the principal business of the Company, enter new lines of business, or exit the current line of business;

 

(i)                                     sell, assign, license, pledge, or encumber material technology or intellectual property, other than licenses, material transfer agreements, or other similar agreements granted in the ordinary course of business; or

 

(j)                                    make any material investments, joint ventures or acquisitions.

 

5.5.                            Meetings of the Board of Directors.  Unless otherwise determined by the vote of a majority of the directors then in office, the Board of Directors shall meet at least four (4) times per year in accordance with an agreed-upon schedule.

 

5.6.                            Successor Indemnification.  If the Company or any of its successors or assignees (i) consolidates with or merges into any other Person and is not the continuing or surviving corporation or entity of such consolidation or merger or (ii) transfers or conveys all or substantially all of its properties and assets to any Person, then, and in each such case, to the extent necessary, proper provision shall be made so that the successors and assignees of the Company assume the obligations of the Company with respect to indemnification of members of the Board of Directors as in effect immediately before such transaction, whether such obligations are contained in the Company’s Bylaws, its Charter, the Indemnification Agreements (as defined in the Purchase Agreement) or elsewhere, as the case may be.

 

5.7.                            Board Expenses.  The Company shall reimburse the nonemployee directors for all reasonable out-of-pocket travel expenses incurred in connection with attending meetings of the Board of Directors.

 

5.8.                            Board Committees.  The MPM Director, the Prism Director, the TVM Director, the Skyline Director, the Abingworth Director and the Pharmstandard Director (each as

 

24

 

defined in the Voting Agreement) shall have the right to join any committee of the Board of Directors.

 

5.9.                            Termination of Covenants.  The covenants set forth in this Section 5, except for Section 5.6, shall terminate and be of no further force or effect (i) immediately before the consummation of the IPO or (ii) upon a Deemed Liquidation Event, as such term is defined in the Charter, whichever event occurs first.

 

5.10.                     Annual Review of Science and Technology and Business.  Each Major Holder shall have the right to have the science and technology and the business of the Company reviewed once a calendar year by one or more representatives of the Major Holder, which may include third party consultants, and at the Major Holder’s expense.

 

5.11.                     Scientific Advisory Board.  If the Company forms a scientific advisory board or any board or committee with similar functions, each Major Holder shall have the right to designate up to one individual to serve on such board or committee.

 

6.                                      Miscellaneous.

 

6.1.                            Successors and Assigns.  Each Investor hereby agrees that it shall not, and may not, assign any of its rights and obligations hereunder, unless such rights and obligations are assigned by such Investor to (i) any Person to which Registrable Securities are transferred by such Investor pursuant to Section 2.13 or (ii) with respect to the right of first offer set forth in Section 4.1, to any Major Holder or any Affiliate of a Major Holder, and, in each case, such assignee shall be deemed an “Investor” for purposes of this Agreement; provided that such assignment of rights shall be contingent upon the assignee providing a written instrument to the Company notifying the Company of such assignment and agreeing in writing to be bound by the terms of this Agreement.  The terms and conditions of this Agreement inure to the benefit of and are binding upon the respective successors and permitted assignees of the parties.  Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective successors and permitted assignees any rights, remedies, obligations or liabilities under or by reason of this Agreement, except as expressly provided herein.

 

6.2.                            Governing Law.  This Agreement shall be governed by and construed in accordance with the General Corporation Law of the State of Delaware as to matters within the scope thereof, and as to all other matters shall be governed by and construed in accordance with the internal laws of the Commonwealth of Massachusetts, without regard to its principles of conflicts of laws.

 

6.3.                            Counterparts.  This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.  This Agreement may also be executed and delivered by facsimile signature and in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.

 

6.4.                            Titles and Subtitles.  The titles and subtitles used in this Agreement are for convenience only and are not to be considered in construing or interpreting this Agreement.

 

25

 

6.5.                            Notices.  All notices, requests, and other communications given or made pursuant to this Agreement shall be in writing and shall be deemed effectively given (i) upon personal delivery to the party to be notified; (ii) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the recipient, and if not so confirmed, then on the next business day; (iii) five (5) calendar days after having been sent by registered or certified mail, return receipt requested, postage prepaid; or (iv) one (1) day after deposit with a nationally recognized overnight courier, specifying next-day delivery, with written verification of receipt.  All communications shall be sent to the respective parties at their addresses as set forth on the signature pages, or to such email address, facsimile number, or address as subsequently modified by written notice given in accordance with this Section 6.5.  If notice is given to the Company, a copy shall also be sent to:

 

Julio E. Vega

Bingham McCutchen LLP

One Federal Street

Boston, MA 02110

e-mail:  julio.vega@bingham.com

fax:  617-951-8736

 

and if notice is given to the Investors, a copy shall also be given to:

 

Lowell A. Segal

Ropes & Gray LLP

1900 University Avenue, 6th Floor
 East Palo Alto, CA 94303

e-mail:  Lowell.Segal@ropesgray.com

fax:  650-566-4244

 

6.6.                            Amendments and Waivers.  Any term of this Agreement may be amended and the observance of any term of this Agreement may be waived (either generally or in a particular instance, and either retroactively or prospectively) only with the written consent of the Company and the holders of at least seventy percent (70%) of the Registrable Securities then-outstanding and the holders of at least a majority of Registrable Securities issued or issuable upon conversion of the Series D Preferred Stock then-outstanding; provided that the Company may in its sole discretion waive compliance with Section 2.14(c) (and the Company’s failure to object promptly in writing to a proposed assignment allegedly in violation of Section 2.14(c) shall be deemed to be a waiver).  Notwithstanding the foregoing, (a) this Agreement may not be amended or terminated and the observance of any term hereof may not be waived with respect to any Investor without the written consent of such Investor, unless such amendment, termination, or waiver applies to all Investors in the same fashion, subject to clause (b) below (it being agreed that (i) a waiver of the provisions of Section 4 with respect to a particular transaction shall be deemed to apply to all Investors in the same fashion if such waiver does so by its terms, notwithstanding the fact that certain Investors may nonetheless, by agreement with the Company, purchase securities in such transaction and (ii) in the event that any Major Holder purchases securities in such transaction, the Company shall offer to each Qualified Investor, with reasonable advance notice, the opportunity to purchase their respective pro rata percentage of any New Securities that the Board of Directors of the Company determines, in good faith, to be

 

26

 

available for purchase by Investors in such transaction (such pro rata percentage being the ratio of shares of the Corporation’s capital stock (on an as-converted basis) held by each Investor purchasing New Securities in such transaction to the sum of the total number of shares of the Corporation’s capital stock (on an as-converted basis) held by all Investors purchasing New Securities in such transaction)), and (b) the exception to the “market stand-off” provision contained in Section 2.12 for shares purchased by an Investor in the IPO  may not be amended or waived in an adverse manner with respect to any Investor without the written consent of such Investor.  The Company shall give prompt notice of any amendment or termination hereof or waiver hereunder to any party hereto that did not consent in writing to such amendment, termination, or waiver.  Any amendment, termination, or waiver effected in accordance with this Section 6.6 shall be binding on all parties hereto, regardless of whether any such party has consented thereto, except as otherwise provided in clause (b) above.  No waivers of or exceptions to any term, condition, or provision of this Agreement, in any one or more instances, shall be deemed to be or construed as a further or continuing waiver of any such term, condition, or provision.

 

6.7.                            Severability.  In case any one or more of the provisions contained in this Agreement is for any reason held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other provision of this Agreement, and such invalid, illegal, or unenforceable provision shall be reformed and construed so that it will be valid, legal, and enforceable to the maximum extent permitted by law.

 

6.8.                            Aggregation of Stock.  All shares of Registrable Securities held or acquired by Affiliates shall be aggregated together for the purpose of determining the availability of any rights under this Agreement.

 

6.9.                            Additional Investors.  Notwithstanding anything to the contrary contained herein, if the Company issues additional shares of the Company’s Preferred Stock after the date hereof, whether pursuant to the Purchase Agreement or otherwise, any purchaser of such shares of Preferred Stock may become a party to this Agreement by executing and delivering an additional counterpart signature page to this Agreement, and thereafter shall be deemed an “Investor” for all purposes hereunder.  No action or consent by the Investors shall be required for such joinder to this Agreement by such additional Holder, so long as such additional Holder has agreed in writing to be bound by all of the obligations as an “Investor” hereunder.

 

6.10.                     Entire Agreement.  This Agreement (including the Exhibits hereto) supersedes the Prior Agreement, and together with the Charter and the other Transaction Agreements (as defined in the Purchase Agreement) constitutes the full and entire understanding and agreement between the parties with respect to the subject matter hereof, and any other written or oral agreements relating to the subject matter hereof existing between the parties are expressly canceled.

 

6.11.                     Dispute Resolution.  The parties (a) hereby irrevocably and unconditionally submit to the jurisdiction of the state courts of Massachusetts and to the jurisdiction of the United States District Court for the District of Massachusetts for the purpose of any suit, action or other proceeding arising out of or based upon this Agreement, (b) agree not to commence any suit, action or other proceeding arising out of or based upon this Agreement

 

27

 

except in the state courts of Massachusetts or the United States District Court for the District of Massachusetts, and (c) hereby waive, and agree not to assert, by way of motion, as a defense, or otherwise, in any such suit, action or proceeding, any claim that it is not subject personally to the jurisdiction of the above-named courts, that its property is exempt or immune from attachment or execution, that the suit, action or proceeding is brought in an inconvenient forum, that the venue of the suit, action or proceeding is improper or that this Agreement or the subject matter hereof may not be enforced in or by such court.  Each party will bear its own costs in respect of any disputes arising under this Agreement.  Each of the parties to this Agreement consents to personal jurisdiction for any equitable action sought in the U.S. District Court for the District of Massachusetts or any court of the Commonwealth of Massachusetts having subject matter jurisdiction.

 

6.12.       Delays or Omissions.  No delay or omission to exercise any right, power, or remedy accruing to any party under this Agreement, upon any breach or default of any other party under this Agreement, shall impair any such right, power, or remedy of such nonbreaching or nondefaulting party, nor shall it be construed to be a waiver of or acquiescence to any such breach or default, or to any similar breach or default thereafter occurring, nor shall any waiver of any single breach or default be deemed a waiver of any other breach or default theretofore or thereafter occurring.  All remedies, whether under this Agreement or by law or otherwise afforded to any party, shall be cumulative and not alternative.

 

[Remainder of Page Intentionally Left Blank]

 

28

 

IN WITNESS WHEREOF, the parties have executed this Fourth Amended and Restated Investors’ Rights Agreement as of the date first written above.

 

	
 
    	
PROTEON THERAPEUTICS, INC.
    
	
 
    	
 
    
	
 
    	
By:
    	
/s/   Timothy Noyes
    
	
 
    	
 
    	
Timothy   Noyes
    
	
 
    	
 
    	
President   and Chief Executive Officer
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    
	
 
    	
 
    	
200   West Street
    
	
 
    	
 
    	
Waltham,   MA 02451
    
	
 
    	
 
    	
 
    
	
 
    	
Email:   
    
	
 
    	
Fax:   
    
				

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Abingworth   Bioventures VI, LP
    
	
 
    	
 
    
	
 
    	
By:
    	
 
    
	
 
    	
By:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Partner
    
	
 
    	
 
    
	
 
    	
Address:
    	
38   Jermyn Street 
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
London   SW1Y 6DN 
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
United   Kingdom
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
				

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Pharmstandard   International S.A.
    
	
 
    	
 
    
	
 
    	
By:
    	
/s/   Ericks Martinovsky
    	
/s/   Gerard Birchen
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Director
    	
Director
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
65   Boulevard Grande Duchesse 
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Charlotte
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
L-1331   Luxembourg
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Grand-Duchey   of Luxembourg
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Deerfield   Special Situations International Master Fund, L.P. 
    
	
 
    	
 
    
	
 
    	
By:
    	
Deerfield   Mgmt, L.P.
    
	
 
    	
 
    	
General   Partner
    
	
 
    	
 
    	
By:
    	
J.E.   Flynn Capital LLC
    
	
 
    	
 
    	
 
    	
General   Partner
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    	
By:
    	
/s/   David J. Clark
    
	
 
    	
 
    	
 
    	
Name:
    	
David   J. Clark
    
	
 
    	
 
    	
 
    	
Title:
    	
Authorized   Signatory
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
780   Third Avenue, 37th Floor
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
New   York, NY 10017
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
						

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Deerfield   Special Situations Fund, L.P. 
    
	
 
    	
 
    
	
 
    	
By:
    	
Deerfield   Mgmt, L.P.
    
	
 
    	
 
    	
General   Partner
    
	
 
    	
 
    	
By:
    	
J.E.   Flynn Capital LLC
    
	
 
    	
 
    	
 
    	
General   Partner
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    	
By:
    	
/s/   David J. Clark
    
	
 
    	
 
    	
 
    	
Name:
    	
David   J. Clark
    
	
 
    	
 
    	
 
    	
Title:
    	
Authorized   Signatory
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
780   Third Avenue, 37th Floor
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
New   York, NY 10017
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
						

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Deerfield   Private Design Fund III, L.P. 
    
	
 
    	
 
    
	
 
    	
By:
    	
Deerfield   Mgmt, L.P.
    
	
 
    	
 
    	
General   Partner
    
	
 
    	
 
    	
By:
    	
J.E.   Flynn Capital LLC
    
	
 
    	
 
    	
 
    	
General   Partner
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    	
By:
    	
/s/   David J. Clark
    
	
 
    	
 
    	
 
    	
Name:
    	
David   J. Clark
    
	
 
    	
 
    	
 
    	
Title:
    	
Authorized   Signatory
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
780   Third Avenue, 37th Floor
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
New   York, NY 10017
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
						

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
TVM   Life Science Ventures VI GmbH & Co. KG 
    
	
 
    	
 
    
	
 
    	
By:
    	
/s/   Josef Moosholzer
    	
/s/   Stefan Fischer
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
Josef   Moosholzer (and) Stefan Fischer
    
	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Authorized   Officers
    
	
 
    	
 
    
	
 
    	
Address:
    	
Ottostrasse   4, 80333 Munich
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Germany   
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
TVM   Life Science Ventures VI LP
    
	
 
    	
By:
    	
its   General Partner TVM Life
    
	
 
    	
 
    	
Science   Ventures VI (Cayman) Ltd.
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
By:
    	
/s/   Josef Moosholzer
    	
/s/   Stefan Fischer
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
Josef   Moosholzer (and) Stefan Fischer
    
	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Authorized   Officers
    
	
 
    	
 
    
	
 
    	
Address:
    	
75   Arlington St. Suite 500
    
	
 
    	
 
    	
Boston,   MA 02116, U.S.A.
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Skyline   Venture Partners Qualified Purchaser Fund IV, L.P.
    
	
 
    	
By:
    	
Skyline   Venture Management IV, LLC, its General Partner
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
/s/   John G. Freund
    
	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
John   G. Freund, Managing Director
    
	
 
    	
 
    
	
 
    	
Address:
    	
525   University Ave., Suite 610
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Palo   Alto, CA 94301
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
				

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Prism   Venture Partners V, L.P.
    
	
 
    	
By:
    	
Prism   Investment Partners V, L.P.
    
	
 
    	
 
    	
its   General Partner
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
Prism   Venture Partners V, L.L.C.
    
	
 
    	
 
    	
its   General Partner
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
/s/   Brendan O’Leary
    
	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Managing   Director
    
	
 
    	
NOTE   NEW ADDRESS:
    	
 
    
	
 
    	
75   Second Avenue, Suite 210
    	
Address:
    	
117   Kendrick Street, Suite 200
    
	
 
    	
Needham,   MA 02494
    	
 
    	
 
    
	
 
    	
 
    	
 
    	
Needham,   MA 02494
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Prism   Venture Partners V-A, L.P.
    
	
 
    	
By:
    	
Prism   Investment Partners V, L.P.
    
	
 
    	
 
    	
its   General Partner
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
Prism   Venture Partners V, L.L.C.
    
	
 
    	
 
    	
its   General Partner
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
/s/   Brendan O’Leary
    
	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Managing   Director
    
	
 
    	
NOTE   NEW ADDRESS:
    	
 
    
	
 
    	
75   Second Avenue, Suite 210
    	
Address:
    	
117   Kendrick Street, Suite 200
    
	
 
    	
Needham,   MA 02494
    	
 
    	
 
    
	
 
    	
 
    	
 
    	
Needham,   MA 02494
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Intersouth   Partners VI, L.P.
    
	
 
    	
By:
    	
Intersouth   Associates VI, LLC
    
	
 
    	
 
    	
its   General Partner
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
PARTNER
    
	
 
    	
 
    
	
 
    	
Address:
    	
102   City Hall Plaza, Suite 200
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Durham,   NC 27701
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
				

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
MPM   Bio IV NVS Strategic Fund, L.P.
    
	
 
    	
By:
    	
MPM   Bioventures IV GP LLC
    
	
 
    	
 
    	
its   General Partner
    
	
 
    	
By:
    	
MPM   Bioventures IV LLC.
    
	
 
    	
 
    	
its   Managing Member
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
/s/   Todd Foley
    
	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Member
    
	
 
    	
 
    
	
 
    	
Address:
    	
200   Clarendon Street, 54th Floor
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Boston,   MA 02116
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
				

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Vectis   Healthcare & Life Sciences Fund II, L.P.
    
	
 
    	
 
    
	
 
    	
By:
    	
Vectis   II GP, LP
    
	
 
    	
 
    	
its   General Partner
    
	
 
    	
By:
    	
Vectis   II GP, LLC
    
	
 
    	
 
    	
General   Partner
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Authorized   Person
    
	
 
    	
 
    
	
 
    	
Address:
    	
84   State Street, Suite 320
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Boston,   MA 02109
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
				

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Devon   Park Bioventures, L.P.
    
	
 
    	
By:
    	
Devon   Park Associates, L.P.
    
	
 
    	
 
    	
its   General Partner
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
/s/   Marc J. Ostro
    
	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
General   Partner
    
	
 
    	
 
    
	
 
    	
Address:
    	
1400   Liberty Ridge Drive
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Suite   103
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Wayne,   PA 19087
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
				

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
BVP   VII Special Opportunity Fund LP
    
	
 
    	
By:
    	
Deer   VII & Co. L.P., their General Partner
    
	
 
    	
By:
    	
Deer   VII & Co. Ltd., its General Partner
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Director
    
	
 
    	
 
    
	
 
    	
Address:
    	
c/o   Bessemer Venture Partners
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
1865   Palmer Avenue, Suite 104
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Larchmont,   NY 10538
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
				

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Fourth Amended and Restated Investors’ Rights Agreement

 

Investor Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is an “Investor” as defined in the Fourth Amended and Restated Investors’ Rights Agreement dated as of May 13, 2014, as amended and in effect from time to time (the “Investors’ Rights Agreement”), by and among Proteon Therapeutics, Inc. and the parties named therein, (ii) that he, she or it is a party to the Investors’ Rights Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Investors’ Rights Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Bessemer   Venture Partners VII, L.P.
    
	
 
    	
By:
    	
Deer   VII & Co. L.P., their General Partner
    
	
 
    	
By:
    	
Deer   VII & Co. Ltd., its General Partner
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Director
    
	
 
    	
 
    
	
 
    	
Address:
    	
c/o   Bessemer Venture Partners
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
1865   Palmer Avenue, Suite 104
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Larchmont,   NY 10538
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
				

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

FOURTH AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT]Exhibit 4.3

 

Execution Version

 

SERIES D PREFERRED STOCK

PURCHASE AGREEMENT

 

 

TABLE OF CONTENTS

 

	
 
    	
 
    	
Page
    
	
 
    	
 
    	
 
    
	
1.
    	
PURCHASE   AND SALE OF PREFERRED STOCK
    	
1
    
	
 
    	
 
    	
 
    
	
 
    	
1.1.
    	
Sale   and Issuance of Series D Preferred Stock
    	
1
    
	
 
    	
1.2.
    	
Closings;   Delivery
    	
6
    
	
 
    	
1.3.
    	
Updates   to Disclosure Schedule
    	
8
    
	
 
    	
1.4.
    	
Use   of Proceeds
    	
8
    
	
 
    	
1.5.
    	
Special   Mandatory Conversion; Limitation on Remedies
    	
8
    
	
 
    	
1.6.
    	
Waiver   of Preemptive Rights
    	
9
    
	
 
    	
1.7.
    	
Defined   Terms Used in this Agreement
    	
9
    
	
 
    	
1.8.
    	
Conversion   Price Adjustment
    	
15
    
	
 
    	
 
    	
 
    	
 
    
	
2.
    	
INDIVIDUAL   PURCHASE RIGHTS OF EACH PURCHASER
    	
16
    
	
 
    	
 
    	
 
    
	
 
    	
2.1.
    	
Exercise   of Individual Purchase Rights
    	
16
    
	
 
    	
2.2.
    	
Closings;   Delivery
    	
21
    
	
 
    	
 
    	
 
    	
 
    
	
3.
    	
REPRESENTATIONS   AND WARRANTIES OF THE COMPANY
    	
22
    
	
 
    	
 
    	
 
    
	
 
    	
3.1.
    	
Organization,   Good Standing, Corporate Power and Qualification
    	
22
    
	
 
    	
3.2.
    	
Capitalization
    	
22
    
	
 
    	
3.3.
    	
Subsidiaries
    	
23
    
	
 
    	
3.4.
    	
Authorization
    	
24
    
	
 
    	
3.5.
    	
Valid   Issuance of Shares
    	
24
    
	
 
    	
3.6.
    	
Governmental   Consents and Filings
    	
24
    
	
 
    	
3.7.
    	
Litigation
    	
25
    
	
 
    	
3.8.
    	
Intellectual   Property
    	
25
    
	
 
    	
3.9.
    	
Compliance   with Other Instruments
    	
27
    
	
 
    	
3.10.
    	
Agreements;   Actions
    	
27
    
	
 
    	
3.11.
    	
Certain   Transactions
    	
27
    
	
 
    	
3.12.
    	
Rights   of Registration and Voting Rights
    	
28
    
	
 
    	
3.13.
    	
Absence   of Liens
    	
29
    
	
 
    	
3.14.
    	
Financial   Statements
    	
29
    
	
 
    	
3.15.
    	
Changes
    	
29
    
	
 
    	
3.16.
    	
Employee   Matters
    	
31
    
	
 
    	
3.17.
    	
Tax   Returns and Payments
    	
32
    
	
 
    	
3.18.
    	
Insurance
    	
32
    
	
 
    	
3.19.
    	
Confidential   Information and Invention Assignment Agreements
    	
32
    
	
 
    	
3.20.
    	
Permits
    	
33
    
	
 
    	
3.21.
    	
Corporate   Documents
    	
33
    
	
 
    	
3.22.
    	
Real   Property Holding Corporation
    	
33
    
	
 
    	
3.23.
    	
Environmental   and Safety Laws
    	
33
    
	
 
    	
3.24.
    	
No   General Solicitation
    	
34
    
	
 
    	
3.25.
    	
Disclosure
    	
34
    
	
 
    	
3.26.
    	
Regulatory   Compliance
    	
34
    

 

i

 

TABLE OF CONTENTS

(continued)

 

	
 
    	
 
    	
Page
    
	
 
    	
 
    	
 
    
	
 
    	
3.27.
    	
Studies
    	
35
    
	
 
    	
 
    	
 
    	
 
    
	
4.
    	
REPRESENTATIONS   AND WARRANTIES OF THE PURCHASERS
    	
35
    
	
 
    	
 
    	
 
    
	
 
    	
4.1.
    	
Authorization
    	
35
    
	
 
    	
4.2.
    	
Purchase   Entirely for Own Account
    	
35
    
	
 
    	
4.3.
    	
Disclosure   of Information
    	
36
    
	
 
    	
4.4.
    	
Restricted   Securities
    	
36
    
	
 
    	
4.5.
    	
No   Public Market
    	
36
    
	
 
    	
4.6.
    	
Legends
    	
36
    
	
 
    	
4.7.
    	
Accredited   Investor
    	
36
    
	
 
    	
4.8.
    	
Foreign   Investors
    	
37
    
	
 
    	
4.9.
    	
No   General Solicitation
    	
37
    
	
 
    	
4.10.
    	
Exculpation   Among Purchasers
    	
37
    
	
 
    	
4.11.
    	
Residence
    	
37
    
	
 
    	
 
    	
 
    	
 
    
	
5.
    	
CLOSING   CONDITIONS
    	
37
    
	
 
    	
 
    	
 
    
	
 
    	
5.1.
    	
Conditions   to the Purchasers’ Obligations at Initial Tranche Closing
    	
37
    
	
 
    	
5.2.
    	
Conditions   to the Purchasers’ Obligations at Second Tranche Closing
    	
39
    
	
 
    	
5.3.
    	
Conditions   to the Purchasers’ Obligations at Third Tranche Closing
    	
40
    
	
 
    	
5.4.
    	
Conditions   to the Company’s Obligations at Initial Tranche Closing
    	
41
    
	
 
    	
5.5.
    	
Conditions   to the Company’s Obligations at Second Tranche Closing
    	
41
    
	
 
    	
5.6.
    	
Conditions   to the Company’s Obligations at Third Tranche Closing
    	
42
    
	
 
    	
 
    	
 
    	
 
    
	
6.
    	
MISCELLANEOUS
    	
42
    
	
 
    	
 
    	
 
    
	
 
    	
6.1.
    	
Survival   of Warranties
    	
42
    
	
 
    	
6.2.
    	
Successors   and Assigns
    	
42
    
	
 
    	
6.3.
    	
Governing   Law
    	
42
    
	
 
    	
6.4.
    	
Counterparts;   Facsimile
    	
43
    
	
 
    	
6.5.
    	
Titles   and Subtitles
    	
43
    
	
 
    	
6.6.
    	
Notices
    	
43
    
	
 
    	
6.7.
    	
No   Finder’s Fees
    	
43
    
	
 
    	
6.8.
    	
Fees   and Expenses
    	
44
    
	
 
    	
6.9.
    	
Amendments   and Waivers
    	
44
    
	
 
    	
6.10.
    	
Severability
    	
44
    
	
 
    	
6.11.
    	
Delays   or Omissions
    	
44
    
	
 
    	
6.12.
    	
Entire   Agreement
    	
44
    
	
 
    	
6.13.
    	
Dispute   Resolution
    	
45
    
	
 
    	
6.14.
    	
No   Commitment for Additional Financing
    	
45
    
	
 
    	
6.15.
    	
Covenant   Relating to Registration
    	
45
    

 

ii

 

	
Exhibit A
    	
Schedule   of Purchasers
    
	
Exhibit B
    	
Form   of Fifth Amended and Restated Certificate of Incorporation
    
	
Exhibit C
    	
Disclosure   Schedule
    
	
Exhibit D
    	
Form   of Investors’ Rights Agreement
    
	
Exhibit E
    	
Form   of Management Rights Letter
    
	
Exhibit F
    	
Form   of Right of First Refusal and Co-Sale Agreement
    
	
Exhibit G
    	
Form   of Voting Agreement
    
	
Exhibit H-1
    	
Form   of Legal Opinion of Company Counsel Delivered at Initial Tranche Closing
    
	
Exhibit H-2
    	
Form   of Legal Opinion of Company Counsel Delivered at Second Tranche Closing
    
	
Exhibit H-3
    	
Form   of Legal Opinion of Company Counsel Delivered at Third Tranche Closing
    
	
Exhibit I
    	
Net   Issue Election Form
    
	
Exhibit J
    	
Form   of Indemnification Agreement
    

 

 

SERIES D PREFERRED STOCK PURCHASE AGREEMENT

 

THIS SERIES D PREFERRED STOCK PURCHASE AGREEMENT (the “Agreement”) is made as of the 13th day of May, 2014 by and among Proteon Therapeutics, Inc., a Delaware corporation (the “Company”), and the investors listed on Exhibit A attached to this Agreement, as the same may be amended from time to time (each a “Purchaser” and together the “Purchasers”).  The parties hereby agree as follows:

 

1.                                      Purchase and Sale of Preferred Stock.

 

1.1.                            Sale and Issuance of Series D Preferred Stock.

 

(a)                                 Authorization. The Company shall adopt and file with the Secretary of State of the State of Delaware on or before the Initial Tranche Closing (as defined in Section 1.2(a)(i) hereof) the Fifth Amended and Restated Certificate of Incorporation in the form of Exhibit B attached to this Agreement (the “Restated Certificate”).

 

(b)                                 Initial Tranche.

 

(i)                                     Subject to the terms and conditions of this Agreement, each Purchaser (a “Noteholder Purchaser”) that is a holder of one or more outstanding convertible promissory notes previously issued by the Company as reflected opposite such Purchaser’s name under the heading “Convertible Notes Amount Owed” on Exhibit A (in the case of such Noteholder Purchaser, the “Applicable Convertible Note(s)”) hereby agrees that, at the Initial Tranche Closing, the full amount owed by the Company to such Noteholder Purchaser through and including the date of the Initial Tranche Closing under such Noteholder Purchaser’s Applicable Convertible Note(s), which full amount owed is set forth opposite such Noteholder Purchaser’s name under the heading “Convertible Notes Amount Owed” on Exhibit A, shall convert into that number of shares of the Company’s Series D Preferred Stock, par value $0.001 per share (“Series D Preferred Stock”), set forth opposite such Noteholder Purchaser’s name under the heading “Note Conversion Shares” on Exhibit A (in the case of each Noteholder Purchaser, the “Note Conversion Shares” and, collectively with the Note Conversion Shares of all other Noteholder Purchasers, the “Total Note Conversion Shares”), at a conversion price per share equal to $0.4414 (the “Note Conversion Price”).  Subject to the terms and conditions of this Agreement, the Company hereby agrees that, at the Initial Tranche Closing, the Company shall sell and issue to each Noteholder Purchaser the Note Conversion Shares to which such Noteholder Purchaser is entitled pursuant to the foregoing provisions of this Section 1.1(b)(i) upon conversion of the full amount owed by the Company to such Noteholder Purchaser through and including the date of the Initial Tranche Closing under such Noteholder Purchaser’s Applicable Convertible Notes.  The number of Total Note Conversion Shares to be issued to the Noteholder Purchasers at the Initial Tranche Closing shall be 10,344,201.  Notwithstanding anything to the contrary express or implied in the Applicable Convertible Note(s) of each Noteholder Purchaser, each Noteholder Purchaser hereby agrees that interest shall accrue under the Applicable Convertible Note(s) of such Noteholder Purchaser only through and including April 30, 2014.  Upon the sale and issuance of the Note Conversion Shares by the Company to each Noteholder Purchaser at the Initial Tranche Closing pursuant to, and in accordance with, the

 

1

 

terms and conditions of this Agreement (including, without limitation, this Section 1.1(b)(i)), the Applicable Convertible Note(s) of such Noteholder Purchaser shall be deemed satisfied in full and the Company shall not owe any amount or have any other obligation of any kind under such Applicable Convertible Note(s), and such Applicable Convertible Note(s) shall be deemed cancelled, terminated and of no further force or effect whatsoever.  Each Noteholder Purchaser hereby agrees that, in the event that any provision of this Agreement (including, without limitation, this Section 1.1(b)(i)) conflicts with or is inconsistent with the terms and provisions of the Applicable Convertible Note(s) of any Noteholder Purchaser, then the conflicting or inconsistent terms and provisions of this Agreement (including, without limitation, this Section 1.1(b)(i)) (1) shall be deemed to constitute an amendment or modification of the conflicting or inconsistent terms and provisions of the Applicable Convertible Note(s) of any Noteholder Purchaser and (2) shall be deemed to supersede and control any such conflicting or inconsistent terms and provisions of the Applicable Convertible Note(s).

 

(ii)                                  Subject to the terms and conditions of this Agreement, at the Initial Tranche Closing, the Company shall issue and sell to each Purchaser, and each Purchaser, acting severally and not jointly, shall purchase from the Company, that number of shares of the Company’s Series D Preferred Stock set forth opposite each such Purchaser’s name under the heading “Initial Tranche Shares” on Exhibit A, at a purchase price per share equal to $0.588656 (such purchase price per share, subject to proportionate and equitable adjustment upon any stock split, stock dividend, reverse stock split or other similar event that affects or involves the Series D Preferred Stock, being hereinafter referred to as the “Series D Price”).  The aggregate number of shares of Series D Preferred Stock issued to the Purchasers at the Initial Tranche Closing pursuant to this Section 1.1(b)(ii) shall be 42,469,626 and the aggregate purchase price payable by the Purchasers at the Initial Tranche Closing for such aggregate number of shares shall be $25,000,000.27. For purposes of this Agreement, the term “Initial Tranche Shares” shall mean, collectively, (1) the Total Note Conversion Shares and (2) the aggregate number of shares of Series D Preferred Stock issued to the Purchasers at the Initial Tranche Closing pursuant to this Section 1.1(b)(ii), subject to, in the case of clauses (1) and (2), proportionate and equitable adjustment upon any stock split, stock dividend, reverse stock split or other similar event that affects or involves the Series D Preferred Stock.

 

(c)                                  Second Tranche.

 

(i)                                     Subject to the terms and conditions of this Agreement (including, without limitation, the terms and conditions set forth below in this Section 1.1(c)), at the Second Tranche Closing (as defined in Section 1.2(b)(i) hereof), the Company shall issue and sell to each Purchaser, and each Purchaser, acting severally and not jointly, shall purchase from the Company, that number of shares of Series D Preferred Stock set forth opposite each such Purchaser’s name under the heading “Second Tranche Shares” on Exhibit A, at a purchase price per share equal to the Series D Price.  Subject to the provisions of this Section 1.1(c), the aggregate number of shares of Series D Preferred Stock issued to the Purchasers at the Second Tranche Closing shall be 8,493,925 (such aggregate number of shares, subject to proportionate and equitable adjustment upon any stock split, stock dividend, reverse stock split or other similar event that affects or involves the Series D Preferred Stock, being hereinafter referred to as the “Second Tranche Shares”) and the aggregate purchase price payable by the Purchasers at the Second Tranche Closing for all of the Second Tranche Shares shall be $5,000,000.03.

 

2

 

(ii)                                  The sale and purchase of the Second Tranche Shares pursuant to this Section 1.1(c) shall be consummated only if (1) the Company delivers a written notice to all of the Purchasers (the “Second Tranche Closing Notice”) stating that the Company desires to consummate such sale and purchase of the Second Tranche Shares pursuant to this Section 1.1(c) and setting forth a proposed date for the Second Tranche Closing that is consistent with the applicable requirements of Section 1.1(c)(iii) below, (2) at any time during the period commencing on the date of the Second Tranche Closing Notice and ending immediately prior to the Second Tranche Closing, those Purchasers that hold at least sixty five percent (65%) of the Tranche Shares (as defined in Section 1.7 hereof) issued and outstanding consent to the consummation of the sale and purchase of the Second Tranche Shares pursuant to this Section 1.1(c) and (3) all other applicable conditions precedent set forth in this Agreement to the consummation of the Second Tranche Closing shall have been satisfied or properly waived in accordance with the terms of this Agreement.  Notwithstanding the foregoing or the provisions of clause (C) of Section 1.1(c)(iii) below, if the sale and purchase of the Second Tranche Shares pursuant to this Section 1.1(c) has not been consummated prior to the consummation of the sale and purchase of the Third Tranche Shares (as defined in Section 1.1(d)(i) below) pursuant to Section 1.1(d) hereof, then the sale and purchase of the Second Tranche Shares pursuant to this Section 1.1(c) shall be consummated simultaneously with the sale and purchase of the Third Tranche Shares pursuant to Section 1.1(d) hereof, and compliance with the provisions of clauses (1) and (2) above in this Section 1.1(c)(ii) and clause (C) of Section 1.1(c)(iii) below shall not be required in connection with such sale and purchase of the Second Tranche Shares.

 

(iii)                               Notwithstanding anything express or implied in the foregoing provisions of this Section 1.1(c) to the contrary:  (A) the Company shall send the Second Tranche Closing Notice at least fifteen (15) business days before the Second Tranche Closing and the Company shall not send the Second Tranche Closing Notice at any time during the Restricted Period; (B) the sale and purchase of the Second Tranche Shares pursuant to this Section 1.1(c) shall not be consummated at any time during the Restricted Period; (C) the sale and purchase of the Second Tranche Shares pursuant to this Section 1.1(c) also shall not be consummated at any time prior to December 31, 2015 or at any time after March 31, 2017, except that the provisions of this clause (C) shall not apply to the sale and purchase of the Second Tranche Shares that, in accordance with the provisions of Section 1.1(c)(ii) above, is consummated simultaneously with the sale and purchase of the Third Tranche Shares; (D) in the event that the sale and purchase of the Second Tranche Shares pursuant to this Section 1.1(c) is to be consummated at any time within thirty (30) days prior to the consummation of a Deemed Liquidation Event (as defined in the Restated Certificate), each Purchaser shall have the right to make a Net Issue Election pursuant to which such Purchaser shall be issued pursuant to this Section 1.1(c), at the Second Tranche Closing, a smaller number of the Second Tranche Shares determined in accordance with such Net Issue Election and without having to make payment to the Company of any cash purchase price in connection with such smaller number of the Second Tranche Shares, in lieu of purchasing and paying the purchase price for the full number of the Second Tranche Shares that such Purchaser would otherwise have the right and obligation to purchase and pay for pursuant to this Section 1.1(c); and (E) the Company shall have no right or obligation to sell any shares of Series D Preferred Stock to a Purchaser pursuant to this Section 1.1(c), and such Purchaser shall have no right or obligation to purchase any shares of Series D Preferred Stock from the Company pursuant to this Section 1.1(c), if the Company has previously sold to such Purchaser, and such Purchaser has previously purchased from the

 

3

 

Company, shares of Series D Preferred Stock pursuant to Section 2.1(a) hereof.  In the event that the provisions of clause (E) of the immediately preceding sentence are applicable with respect to one or more Purchasers, then (1) the rights and obligations of the Purchasers to purchase Second Tranche Shares pursuant to this Section 1.1(c) shall continue to apply only with respect to those Purchasers that have not previously purchased shares of Series D Preferred Stock from the Company pursuant to Section 2.1(a) hereof, (2) the rights and obligations of the Company to sell Second Tranche Shares pursuant to this Section 1.1(c) shall continue to apply only with respect to those Purchasers that have not previously purchased shares of Series D Preferred Stock from the Company pursuant to Section 2.1(a) hereof and (3) the aggregate purchase price payable by the Purchasers at the Second Tranche Closing for all of the Second Tranche Shares shall be automatically reduced to reflect the reduction in the number of Second Tranche Shares.

 

(iv)                              The rights and obligations of the Company and the Purchasers to consummate the sale and purchase of the Second Tranche Shares pursuant to this Section 1.1(c) shall automatically terminate on the earlier of (1) the sixteenth (16th) business day after September 30, 2017, (2) the consummation of a Deemed Liquidation Event, (3) the closing of the IPO (as defined in Section 1.4 hereof) and (4) the date on which all Purchasers have purchased shares of Series D Preferred Stock pursuant to, and in accordance with, Section 2.1(a) hereof.  In addition, if one or more Purchasers is or are in material breach of any representation, warranty, covenant or provision under this Agreement that is applicable to such Purchaser or Purchasers (which material breach remains uncured for at least thirty (30) days after written notice thereof), then the obligation of the Company to consummate the sale of any number of the Second Tranche Shares to such Purchaser or Purchasers pursuant to this Section 1.1(c), and the right of such Purchaser or Purchasers to consummate the purchase of such number of the Second Tranche Shares from the Company pursuant to this Section 1.1(c), may be terminated by the Company by giving written notice of termination to the breaching Purchaser or Purchasers.  Any termination pursuant to this Section 1.1(c)(iv) of the rights and/or obligations of the Company and/or the Purchasers to consummate the sale and purchase of the Second Tranche Shares pursuant to this Section 1.1(c) shall not relieve or release any party to this Agreement from any material breach by such party of any representation, warranty, covenant or provision under this Agreement that is applicable to such party if and to the extent that such material breach occurred prior to such termination.

 

(d)                                 Third Tranche.

 

(i)                                     Subject to the terms and conditions of this Agreement (including, without limitation, the terms and conditions set forth below in this Section 1.1(d)), at the Third Tranche Closing (as defined in section 1.2(c)(i)), the Company shall issue and sell to each Purchaser, and each Purchaser, acting severally and not jointly, shall purchase from the Company, that number of shares of Series D Preferred Stock set forth opposite each such Purchaser’s name under the heading “Third Tranche Shares” on Exhibit A, at a purchase price per share equal to the Series D Price.  Subject to the provisions of this Section 1.1(d), the aggregate number of shares of Series D Preferred Stock issued to the Purchasers at the Third Tranche Closing shall be 25,481,775 (such aggregate number of shares, subject to proportionate and equitable adjustment upon any stock split, stock dividend, reverse stock split or other similar event that affects or involves the Series D Preferred Stock, being hereinafter referred to as the

 

4

 

“Third Tranche Shares”) and the aggregate purchase price payable by the Purchasers at the Third Tranche Closing for all of the Third Tranche Shares shall be $14,999,999.85.

 

(ii)                                  The sale and purchase of the Third Tranche Shares pursuant to this Section 1.1(d) shall be consummated only if (1) either the Board of Directors of the Company determines that the Milestones (as defined in Section 1.4 below) have been achieved or those Purchasers that hold at least seventy-five percent (75%) of the Tranche Shares issued and outstanding agree in writing to waive the requirement that the Milestones be achieved as a condition precedent to such sale and purchase of the Third Tranche Shares pursuant to this Section 1.1(d), (2) the Company delivers a written notice to all of the Purchasers (the “Third Tranche Closing Notice”) stating that (A) the Board of Directors of the Company has determined that the Milestones have been achieved or that the requirement that the Milestones be achieved as a condition precedent to such sale and purchase of the Third Tranche Shares pursuant to this Section 1.1(d) has been waived in accordance with the provisions of the foregoing clause (1) of this Section 1.1(d)(ii) and (B) the Company desires to consummate such sale and purchase of the Third Tranche Shares pursuant to this Section 1.1(d), and setting forth a proposed date for the Third Tranche Closing that is consistent with the applicable requirements of Section 1.1(d)(iii) below, (3) those Purchasers that hold at least seventy-five percent (75%) of the Tranche Shares issued and outstanding do not elect in writing, within ten (10) business days after the date of the Third Tranche Closing Notice, to abandon the consummation of the sale and purchase of the Third Tranche Shares pursuant to this Section 1.1(d) and (4) all other applicable conditions precedent set forth in this Agreement to the consummation of the Third Tranche Closing shall have been satisfied or properly waived in accordance with the terms of this Agreement.  Upon request by any Purchaser, the Company shall promptly provide such Purchaser with reasonable evidence supporting achievement of the Milestones, as applicable, which evidence shall be subject to the confidentiality provisions set forth in Section 3.5 of the Investors’ Rights Agreement.

 

(iii)                               Notwithstanding anything express or implied in this Section 1.1(d) or elsewhere in this Agreement to the contrary: (A) the Company shall send the Third Tranche Closing Notice at least fifteen (15) business days before the Third Tranche Closing and the Company shall not send the Third Tranche Closing Notice at any time during the Restricted Period; (B) the sale and purchase of the Third Tranche Shares pursuant to this Section 1.1(d) shall not be consummated at any time during the Restricted Period and also shall not be consummated at any time prior to December 31, 2015 or after the fifteenth (15th) business day after September 30, 2017; (C) in the event that the sale and purchase of the Third Tranche Shares pursuant to this Section 1.1(d) is to be consummated at any time within thirty (30) days prior to the consummation of a Deemed Liquidation Event, each Purchaser shall have the right to make a Net Issue Election pursuant to which such Purchaser shall be issued pursuant to this Section 1.1(d), at the Third Tranche Closing, a smaller number of the Third Tranche Shares determined in accordance with such Net Issue Election and without having to make payment to the Company of any cash purchase price in connection with such smaller number of the Third Tranche Shares, in lieu of purchasing and paying the purchase price for the full number of the Third Tranche Shares that such Purchaser would otherwise have the right and obligation to purchase and pay for pursuant to this Section 1.1(d); and (D) the Company shall have no right or obligation to sell any shares of Series D Preferred Stock to a Purchaser pursuant to this Section 1.1(d), and such Purchaser shall have no right or obligation to purchase any shares of Series D Preferred Stock

 

5

 

from the Company pursuant to this Section 1.1(d), if the Company has previously sold to such Purchaser, and such Purchaser has previously purchased from the Company, shares of Series D Preferred Stock pursuant to Section 2.1(b) hereof.  In the event that the provisions of clause (D) of the immediately preceding sentence are applicable with respect to one or more Purchasers, then (1) the rights and obligations of the Purchasers to purchase Third Tranche Shares pursuant to this Section 1.1(d) shall continue to apply only with respect to those Purchasers that have not previously purchased shares of Series D Preferred Stock from the Company pursuant to Section 2.1(b) hereof, (2) the rights and obligations of the Company to sell Third Tranche Shares pursuant to this Section 1.1(d) shall continue to apply only with respect to those Purchasers that have not previously purchased shares of Series D Preferred Stock from the Company pursuant to Section 2.1(b) hereof and (3) the aggregate purchase price payable by the Purchasers at the Third Tranche Closing for all of the Third Tranche Shares shall be automatically reduced to reflect the reduction in the number of Third Tranche Shares.

 

(iv)                              The rights and obligations of the Company and the Purchasers to consummate the sale and purchase of the Third Tranche Shares pursuant to this Section 1.1(d) shall automatically terminate on the earlier of (1) the sixteenth (16th) business day after September 30, 2017, (2) the consummation of a Deemed Liquidation Event, (3) the closing of the IPO and (4) the date on which all Purchasers have purchased shares of Series D Preferred Stock pursuant to, and in accordance with, Section 2.1(b) hereof.  In addition, if one or more Purchasers is or are in material breach of any representation, warranty, covenant or provision under this Agreement that is applicable to such Purchaser or Purchasers (which material breach remains uncured for at least thirty (30) days after written notice thereof), then the obligation of the Company to consummate the sale of any number of the Third Tranche Shares to such Purchaser or Purchasers pursuant to this Section 1.1(d), and the right of such Purchaser or Purchasers to consummate the purchase of such number of the Third Tranche Shares from the Company pursuant to this Section 1.1(d), may be terminated by the Company by giving written notice of termination to the breaching Purchaser or Purchasers.  Any termination pursuant to this Section 1.1(d)(iv) of the rights and/or obligations of the Company and/or the Purchasers to consummate the sale and purchase of the Third Tranche Shares pursuant to this Section 1.1(d) shall not relieve or release any party to this Agreement from any material breach by such party of any representation, warranty, covenant or provision under this Agreement that is applicable to such party if and to the extent that such material breach occurred prior to such termination.

 

1.2.                            Closings; Delivery.

 

(a)                                 Initial Tranche Closing.

 

(i)                                     The closing of (1) the conversion of the Applicable Convertible Note(s) of each Noteholder Purchaser and the issuance and sale the Total Note Conversion Shares in connection with such conversion, all pursuant to Section 1.1(b)(i) hereof and (2) the sale and purchase of the shares of Series D Preferred Stock pursuant to Section 1.1(b)(ii) hereof shall take place remotely via the exchange of documents and signatures either (i) at 11:00 am Eastern Standard Time on the fifth (5th) business day after the date of this Agreement or (ii) at such other time and/or date (whether prior or after such fifth (5th) business date) as the Company and the Purchasers mutually agree upon, orally or in writing, which may be on the date hereof (the “Initial Tranche Closing”).

 

6

 

(ii)                                  At the Initial Tranche Closing: (1) the Company shall deliver to each Noteholder Purchaser a certificate representing the Note Conversion Shares of such Noteholder Purchaser, against delivery by such Noteholder Purchaser of the original Applicable Convertible Note(s) of such Noteholder Purchaser or, in the event that such original Applicable Convertible Note(s) have been lost, stolen or destroyed an affidavit of loss, in form and substance satisfactory to the Company, duly executed by such Noteholder Purchaser pursuant to which such Noteholder Purchaser certifies that such original Applicable Convertible Note(s) have been lost, stolen or destroyed and agreeing to customary indemnification of the Company in the event of any claims pertaining to such original Applicable Convertible Note(s); and (2) the Company shall deliver to each Purchaser a certificate representing the shares of Series D Preferred Stock being purchased by such Purchaser pursuant to Section 1.1(b)(ii) hereof, against payment by such Purchaser of the purchase price for such shares of Series D Preferred Stock by check payable to the Company, by wire transfer to a bank account designated by the Company or by any combination of such methods.

 

(b)                                 Second Tranche Closing.

 

(i)                                     The closing of the purchase and sale of the Second Tranche Shares pursuant to Section 1.1(c) hereof shall take place remotely via the exchange of documents and signatures on either the date specified in the Second Tranche Closing Notice delivered pursuant to Section 1.1(c)(ii) hereof, which date specified must be consistent with the applicable requirements of Section 1.1(c)(iii), or on such other date as the Company and those Purchasers that hold at least sixty five percent (65%) of the Initial Tranche Shares then outstanding mutually agree (the “Second Tranche Closing”).

 

(ii)                                  At the Second Tranche Closing, the Company shall deliver to each Purchaser a certificate representing the number of the Second Tranche Shares being purchased by such Purchaser pursuant to Section 1.1(c) hereof, against either (1) payment by such Purchaser of the purchase price for such number of the Second Tranche Shares by check payable to the Company, by wire transfer to a bank account designated by the Company or by any combination of such methods or (2) delivery by such Purchaser of a Net Issue Election Form that has been properly completed and duly executed by such Purchaser if such Purchaser is entitled to make a Net Issue Election pursuant to Section 1.1(c)(iii) in connection with the number of the Second Tranche Shares being purchased by such Purchaser pursuant to Section 1.1(c) hereof.

 

(c)                                  Third Tranche Closing.

 

(i)                                     The closing of the purchase and sale of the Third Tranche Shares pursuant to Section 1.1(d) hereof shall take place remotely via the exchange of documents and signatures on either the date specified in the Third Tranche Closing Notice delivered pursuant to Section 1.1(c)(ii) hereof, which date specified must be consistent with the applicable requirements of Section 1.1(d)(iii), or on such other date as the Company and those Purchasers that hold at least sixty five percent (65%) of the Initial Tranche Shares and Second Tranche Shares, if any, then outstanding mutually agree (the “Third Tranche Closing”).

 

7

 

(ii)                                  At the Third Tranche Closing, the Company shall deliver to each Purchaser a certificate representing the number of the Third Tranche Shares being purchased by such Purchaser pursuant to Section 1.1(d) hereof, against either (1) payment by such Purchaser of the purchase price for such number of the Third Tranche Shares by check payable to the Company, by wire transfer to a bank account designated by the Company or by any combination of such methods or (2) delivery by such Purchaser of a Net Issue Election Form that has been properly completed and duly executed by such Purchaser if such Purchaser is entitled to make a Net Issue Election pursuant to Section 1.1(d)(iii) in connection with the number of the Third Tranche Shares being purchased by such Purchaser pursuant to Section 1.1(d) hereof.

 

(d)                                 Definition of Closing. Each of the Initial Tranche Closing, the Second Tranche Closing (if any) and the Third Tranche Closing (if any), is sometimes referred to herein, individually, as a “Closing.” The Initial Tranche Closing, the Second Tranche Closing (if any) and the Third Tranche Closing (if any) are sometimes referred to in this Agreement, collectively, as the “Closings.”

 

1.3.                            Updates to Disclosure Schedule.  The Company shall have the right to deliver to the Purchasers at each of the Initial Tranche Closing, the Second Tranche Closing and the Third Tranche Closing an amended and restated Disclosure Schedule consisting of the Disclosure Schedule as modified, revised and updated to make such disclosures concerning matters or events occurring or arising since the date hereof or the prior Closing, as the case may be, as are required in order for the representations and warranties of the Company under Section 3 hereof to be true and correct as of each of the Initial Tranche Closing, the Second Tranche Closing or the Third Tranche Closing, as applicable, provided, however, that no such Updated Disclosure Schedule (as defined below) shall cure any breach, inaccuracy, default or non-compliance existing as of the date hereof or any previous Closing, as the case may be. For purposes of this Agreement, the term “Updated Disclosure Schedule” shall mean the last amended and restated Disclosure Schedule delivered pursuant to this Section 1.3.

 

1.4.                            Use of Proceeds.  In accordance with the directions of the Company’s Board of Directors, as it shall be constituted in accordance with the Voting Agreement, the Company will use the proceeds from the sale of the Tranche Shares to advance the Company’s lead product, PRT-201, through Phase III clinical studies, as provided for in the Proposed Budgets (as defined in Section 5.1(n)), and for other general corporate purposes, subject to Section 5.4 of the Investors’ Rights Agreement.

 

1.5.                            Special Mandatory Conversion; Limitation on Remedies.

 

(a)                                 Special Mandatory Conversion.  Each Purchaser hereby acknowledges and agrees that if such Purchaser fails to purchase (i) all of the Second Tranche Shares that such Purchaser is obligated to purchase at the Second Tranche Closing pursuant to, and in accordance with, Section 1.1(c) hereof or (ii) all of the Third Tranche Shares that such Purchaser is obligated to purchase at the Third Tranche Closing pursuant to, and in accordance with, Section 1.1(d) hereof, then, in each case, (x) all of the shares of the Company’s Series D Preferred Stock owned by such Purchaser shall be subject to a special mandatory conversion, such special mandatory conversion to be pursuant to, and in accordance with, the terms and

 

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provisions of Section 5A of Division C of Article Fourth of the Restated Certificate and (y) any right that such Purchaser may have to designate a nominee for election to the Board of Directors of the Company shall terminate in accordance with the provisions of Section 1.7 of the Voting Agreement (as defined in Section 1.7 hereof).

 

(b)                                 Limitation on Remedies.  The parties hereby acknowledge that, if a Purchaser fails to purchase (i) all of the Second Tranche Shares that such Purchaser is obligated to purchase at the Second Tranche Closing pursuant to, and in accordance with, Section 1.1(c) hereof or (ii) all of the Third Tranche Shares that such Purchaser is obligated to purchase at the Third Tranche Closing pursuant to, and in accordance with, Section 1.1(d) hereof, then, in each case, the only remedies available against such Purchaser are (w) the special mandatory conversion of Series D Preferred Stock owned by the Purchaser pursuant to the Restated Certificate, (x) termination, pursuant to Section 1.7 of the Voting Agreement, of the Purchaser’s right, if any, to designate a nominee for election to the Board of Directors of the Company, (y) termination, pursuant to Section 3.4(b) and Section 3.4(c) of the Investors’ Rights Agreement (as defined in Section 1.7 hereof), of the Purchaser’s information and observer rights, if any, and (z) termination, pursuant to Section 4.2 of the Investors’ Rights Agreement, of the Purchaser’s preemptive rights, if any.

 

1.6.                            Waiver of Preemptive Rights.  Certain of the Purchasers, acting for themselves and on behalf of all other stockholders of the Company that have preemptive rights under that certain Third Amended and Restated Investors’ Rights Agreement, dated August 2, 2011, among the Company, certain of the Purchasers and those other stockholders of the Company that are parties thereto, as previously amended and in effect prior to the date of this Agreement (the “Prior Investors’ Rights Agreement”), hereby waive any and all preemptive rights, if any, under Section 4.1 of the Prior Investors’ Rights Agreement with respect to the offer, sale and/or issuance by the Company of the Shares pursuant to this Agreement and the Common Stock issuable upon conversion of the Series D Preferred Stock issued pursuant to this Agreement.

 

1.7.                            Defined Terms Used in this Agreement.  In addition to the terms defined above, the following terms used in this Agreement shall be construed to have the meanings set forth or referenced below.

 

“Abingworth” means Abingworth Bioventures VI, LP.

 

“Affiliate” means, with respect to any specified Person, any other Person who or which, directly or indirectly, controls, is controlled by, or is under common control with such specified Person, including, without limitation, any partner, officer, director, member or employee of such Person and any venture capital fund now or hereafter existing that is controlled by or under common control with one or more general partners or managing members of, or shares the same management company with, such Person.

 

“Applicable Convertible Notes” shall have the meaning set forth in Section 1.1(b)(i) hereto.

 

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“Bessemer” means Bessemer Venture Partners VII L.P., Bessemer Venture Partners VII Institutional L.P. and BVP VII Special Opportunity Fund LP, collectively.

 

“Code” means the Internal Revenue Code of 1986, as amended.

 

“Common Stock” means the Company’s common stock, par value $0.001 per share.

 

“Company Intellectual Property” means all Intellectual Property Rights as are necessary to or actually used in the conduct of the Company’s business as now conducted and as presently proposed to be conducted.

 

“Deerfield” means Deerfield Private Design Fund III, L.P., Deerfield Special Situations Fund, L.P. and Deerfield Special Situations International Master Fund, L.P.

 

“Devon Park” means Devon Park Bioventures, L.P.

 

“Initial Tranche Closing” shall have the meaning set forth in Section 1.2(a) hereof.

 

“Initial Tranche Shares” shall have the meaning set forth in Section 1.1(b) hereof.

 

“Intellectual Property Rights” means patents, patent applications, trademarks, trademark applications, trademark registrations, service marks, service mark applications, service mark registrations, tradenames, copyrights, trade secrets, licenses, domain names, mask works, biological materials, formulae, know how, information, proprietary rights and processes and other intellectual property rights of any kind.

 

“Intersouth” means Intersouth Partners VI, L.P.

 

“Investors’ Rights Agreement” means the agreement between the Company, the Purchasers and the other stockholders of the Company party thereto dated as of the Initial Tranche Closing, in the form of Exhibit D attached to this Agreement.

 

“IPO” means the initial public offering of the Common Stock pursuant to a registration statement filed with the Securities and Exchange Commission under the Securities Act.

 

“Key Employee” means Timothy Noyes, George Eldridge and Steven Burke, any executive-level employee (including division director and vice president-level positions), any employee who either alone or in concert with others develops, invents, programs or designs any Company Intellectual Property and any other employee whose responsibilities consist primarily of being the leader or head of the Company’s clinical, regulatory or manufacturing operations.

 

“Knowledge,” including the phrase “to the Company’s knowledge,” shall mean the actual knowledge of any Key Employee; provided, however, that, solely for the purposes of

 

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Section 3.8 hereof, “Knowledge”, including the phrase “to the Company’s knowledge” shall mean the actual knowledge of any Key Employee, F. Nicholas Franano and Marco Wong.

 

“Major Investor” means each of (i) MPM; (ii) TVM LSV VI GmbH and TVM LSV VI LP collectively, except that for purposes of Section 5.1(m) each of TVM LSV VI GmbH and TVM LSV VI LP individually shall be considered a Major Investor; (iii) Skyline IV; (iv) Prism V LP and Prism V-A LP, collectively; (v) Intersouth; (vi) Devon Park; (vii) Bessemer; (viii) Abingworth; (ix) Pharmstandard; and (x) Deerfield.

 

“Management Rights Letter” means the agreement between the Company and each Major Investor, dated as of the Initial Tranche Closing, in the form of Exhibit E attached to this Agreement or such other form as the Company and a Major Investor shall agree upon.

 

“Material Adverse Effect” means a material adverse effect on the business, assets (including intangible assets), liabilities, financial condition, property, prospects or results of operations of the Company; provided, however, that none of the following shall be deemed in themselves, either alone or in combination, to constitute, and none of the following shall be taken into account in determining whether there has been or will be, a Material Adverse Effect:  (a) any failure by the Company to meet internal projections, forecasts or predictions on or after the date of this Agreement (provided that the underlying causes of such failure shall not be excluded from the determination of whether a Material Adverse Effect has occurred); (b) any adverse change, effect, event, occurrence, state of facts or development attributable to conditions affecting the industries in which Company participates as a whole or the U.S. economy as a whole, unless such change, effect, event, occurrence, state of facts or development affects the Company in a disproportionate manner; (c) any adverse change, effect, event, occurrence, state of facts or development attributable or relating to (i) out-of-pocket fees and expenses (including legal, accounting, investment banking and other fees and expenses) incurred in connection with the transactions contemplated by any of the Transaction Agreements or (ii) the payment of any amounts due to, or the provision of any other benefits (including benefits relating to acceleration of stock options) to, any officers or employees under employment contracts, non-competition agreements, employee benefit plans, severance arrangements or other arrangements in existence as of the date of this Agreement; (d) any adverse change, effect, event, occurrence, state of facts or development resulting from or relating to compliance with the terms of, or the taking of any action required by, any of the Transaction Agreements; or (e) any adverse change or effect on the business, assets, liabilities, financial condition or results of operations of the Company resulting from the conduct of the Company’s business in the ordinary course of business in accordance with budgets approved by the Board of Directors of the Company from time to time, including, without limitation, (1) any reduction of the Company’s cash balance as a result of incurring expenses in the ordinary course of business and the reduction of the Company’s cash balance, (2) any increase in the Company’s liabilities in the ordinary course of business or (3) any deterioration of the financial condition of the Company as a result of the activities contemplated in the foregoing clauses (1) and (2).

 

“Milestones” means the following milestones achieved in a Phase 3 clinical trial with NCT No. 02110901, enrolling no less than 285 patients, and which has been designed based upon FDA’s guidance in the end-of-Phase 2 meeting with the Company to satisfy FDA’s requirements of an adequate, well-controlled trial in support of a BLA filing: (i) statistically

 

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significant effect of PRT-201 compared to placebo on primary patency loss in radiocephalic arteriovenous fistula (“RC-AVF”) patients; and (ii) statistically significant effect of PRT-201 compared to placebo on fistula maturation according to the KDOQI criteria in RC-AVF patients.

 

“MPM” means MPM Bio IV NVS Strategic Fund, LP.

 

“Net Issue Election” means the following:  (i) in the case of a Purchaser’s right and obligation to purchase Shares pursuant to Section 1.1(c) hereof or Section 1.1(d) hereof, as applicable, by making payment of the applicable cash purchase price therefor in accordance with the provisions of Section 1.1(c) or Section 1.1(d), as applicable, Purchaser’s election to have the Company issue to such Purchaser a smaller number of the class or series of Shares than the Purchaser would be required to purchase pursuant to Section 1.1(c) or Section 1.1(d), as applicable, absent such election, which smaller number of such class or series of Shares shall be determined in accordance with the formula provided below and shall be issued by the Company to such Purchaser without such Purchaser being required to make payment to the Company of any cash purchase price therefor; and (ii) in the case of a Purchaser’s right to purchase Shares pursuant to Section 2.1(a) hereof or Section 2.1(b) hereof, as applicable, by making payment of the applicable cash purchase price therefor in accordance with the provisions of Section 2.1(a) hereof or Section 2.1(b) hereof, as applicable, such Purchaser’s election to have the Company issue to such Purchaser a smaller number of the class or series of Shares that such Purchaser would be entitled to purchase pursuant to Section 2.1(a) hereof or Section 2.1(b) hereof, as applicable, absent such election, which smaller number of such class or series of Shares shall be determined in accordance with the formula provided below and shall be issued by the Company to such Purchaser without such Purchaser being required to make payment to the Company of any cash purchase price therefor.  The smaller number of the applicable class or series of Shares to be issued by the Company to any Purchaser that makes a Net Issue Election shall be determined as follows:

 

X =                             Y (A - B)

 

A

 

Where:                     X =                                                     The smaller number of the applicable class or series of Shares to be issued to the Purchaser as a result of such Purchaser’s Net Issue Election;

 

Y =                                                     The number of the applicable class or series of Shares that the Purchaser making the Net Issue Election would have purchased if such Purchaser had not made such Net Issue Election;

 

A =                                                     The fair market value of one Share of the same class or series as the Shares with respect to which the Net Issue Election is made, such fair market value to be determined at the time such Net Issue Election is made as determined in good faith by the Board of Directors based upon (i) if such Net Issue Election is made in connection with  a Deemed Liquidation Event, the consideration per Share payable in connection with such Deemed Liquidation Event or (ii) if such Net Issue Election is made after the closing of an IPO, the average closing price per Share quoted on the national securities exchange on which the Shares are listed as published in the Wall Street Journal for the ten

 

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(10) trading day period ending five (5) trading days prior to the date of determination of fair market value;

 

B =                                                     The cash purchase price per share that the Purchaser is required to pay pursuant to this Agreement in connection with the purchase of the applicable class or series of Shares with respect to which the Net Issue Election is made.

 

“Net Issue Election Form” means the Net Issue Election Form attached as Exhibit I hereto.

 

“Note Conversion Price” shall have the meaning set forth in Section 1.1(b)(i) hereto.

 

“Note Conversion Shares” shall have the meaning set forth in Section 1.1(b)(i) hereto.

 

“Noteholder Purchaser” shall have the meaning set forth in Section 1.1(b)(i) hereto.

 

“Novartis” means Novartis International Pharmaceutical Limited.

 

“Option Agreement” means that certain Option Agreement between the Company and Novartis, dated as of March 27, 2009.

 

“Person” means any individual, corporation, partnership, trust, limited liability company, association or other entity.

 

“Pharmstandard” means Pharmstandard International S.A., with registered address 65, Boulevard Grande-Duchesse Charlotte L - 1331 Luxembourg.

 

“Preferred Stock” means the Series A Preferred Stock, the Series A-1 Preferred Stock, the Series B Preferred Stock, the Series C Preferred Stock and the Series D Preferred Stock.

 

“Prism V LP” means Prism Venture Partners V, L.P.

 

“Prism V-A LP” means Prism Venture Partners V-A, L.P.

 

“Prior Investors’ Rights Agreement” shall have the meaning set forth in Section 1.6.

 

“Proposed Budgets” shall have the meaning set forth in Section 5.1(n).

 

“Purchaser” shall have the meaning set forth in the Preamble.

 

“Restated Certificate” shall have the meaning set forth in Section 1.1(a) hereof.

 

“Restricted Period” means the period commencing on the date on which the Company either submits a registration statement on Form S-1 to the United States Securities and Exchange Commission on a confidential basis pursuant to Jumpstart Our Business Startups Act or files a registration statement on Form S-1 with the United States Securities and Exchange Commission pursuant to the Securities Act and ending on the earlier of (i) the third business day

 

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following the withdrawal of such registration statement on Form S-1 in connection with any abandonment of the IPO and (ii) the closing of the IPO.

 

“Right of First Refusal and Co-Sale Agreement” means the agreement among the Company, the Purchasers, and certain other stockholders of the Company, dated as of the Initial Tranche Closing, in the form of Exhibit F attached to this Agreement.

 

“Second Tranche Closing” shall have the meaning set forth in Section 1.2(b)(i) hereof.

 

“Second Tranche Closing Notice” shall have the meaning set forth in Section 1.1(c)(ii) hereof.

 

“Second Tranche Individual Purchase Exercise Notice” shall have the meaning set forth in Section 2.1(a)(i) hereto.

 

“Second Tranche Individual Purchase Right” shall have the meaning set forth in Section 2.1(a)(i) hereto.

 

“Second Tranche Individual Purchase Shares” shall have the meaning set forth in Section 2.1(a)(i) hereto.

 

“Second Tranche Shares” shall have the meaning set forth in Section 1.1(c)(i) hereof.

 

“Section 2.1(a) Closing” shall have the meaning set forth in Section 2.2(a)(i) hereto.

 

“Section 2.1(b) Closing” shall have the meaning set forth in Section 2.2(b)(i) hereto.

 

“Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.

 

“Series A Preferred Stock” means the Company’s Series A Preferred Stock, par value $0.001 per share.

 

“Series A-1 Preferred Stock” means the Company’s Series A-1 Preferred Stock, par value $0.001 per share.

 

“Series B Preferred Stock” means the Company’s Series B Preferred Stock, par value $0.001 per share.

 

“Series C Preferred Stock” means the Company’s Series C Preferred Stock, par value $0.001 per share.

 

“Series D Preferred Stock” shall have the meaning set forth in Section 1.1(b) hereof.

 

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“Series D Price” shall have the meaning set forth in Section 1.1(b) hereof.

 

“Shares” shall mean, collectively, (i) any shares of Series D Preferred Stock or Common Stock sold or issued pursuant to this Agreement and (ii) any shares of Common Stock issued or issuable upon conversion of any shares of Series D Preferred Stock sold or issued pursuant to this Agreement.

 

“Skyline IV” means Skyline Venture Partners Qualified Purchaser Fund IV, L.P.

 

“Third Tranche Closing” shall have the meaning set forth in Section 1.2(c)(i) hereof.

 

“Third Tranche Closing Notice” shall have the meaning set forth in Section 1.2(c)(i) hereof.

 

“Third Tranche Individual Purchase Exercise Notice” shall have the meaning set forth in Section 2.1(b)(i) hereto.

 

“Third Tranche Individual Purchase Right” shall have the meaning set forth in Section 2.1(b)(i) hereto.

 

“Third Tranche Individual Purchase Shares” shall have the meaning set forth in Section 2.1(b)(i) hereto

 

“Third Tranche Shares” shall have the meaning set forth in Section 1.1(d)(i) hereof.

 

“Total Note Conversion Shares” shall have the meaning set forth in Section 1.1(b)(i) hereto.

 

“Tranche Shares” shall mean, as of the relevant time of reference thereto, those shares of Series D Preferred Stock sold by the Company, and purchased by Purchasers, prior to such time pursuant to Section 1.1(b), Section 1.1(c) and/or Section 1.1(d) hereof, as applicable.

 

“Transaction Agreements” means this Agreement, the Investors’ Rights Agreement, the Management Rights Letter, the Right of First Refusal and Co-Sale Agreement and the Voting Agreement.

 

“TVM LSV VI GmbH” means TVM Life Science Ventures VI GmbH & Co. KG.

 

“TVM LSV VI LP” means TVM Life Science Ventures VI, L.P.

 

“Updated Disclosure Schedule” shall have the meaning set forth in Section 1.3 hereof.

 

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“Voting Agreement” means the agreement among the Company, the Purchasers and certain other stockholders of the Company, dated as of the Initial Tranche Closing, in the form of Exhibit G attached to this Agreement.

 

1.8.                            Conversion Price Adjustment.  The parties acknowledge that, in the event that Shares are issued and sold pursuant to Section 1.1(c) or Section 1.1(d) hereof, the Conversion Price (as defined in the Restated Certificate) applicable to each of the Series A Preferred Stock, the Series A-1 Preferred Stock, the Series B Preferred Stock and the Series C Preferred Stock (but not Series D Preferred Stock) shall adjust in accordance with the provisions of Section 4.4.4 of Division C of Article Fourth of the Restated Certificate.

 

2.                                      Individual Purchase Rights of each Purchaser.

 

2.1.                            Exercise of Individual Purchase Rights.

 

(a)                                 Second Tranche Individual Purchase Right.

 

(i)                                     Subject to the terms and conditions of this Agreement (including, without limitation, the terms and conditions set forth below in this Section 2.1(a)), each Purchaser shall have the right under this Section 2.1(a) to purchase from the Company all (but not less than all) of the number of shares of Series D Preferred Stock set forth opposite such Purchaser’s name under the heading “Second Tranche Shares” on Exhibit A (such number of shares of Series D Preferred Stock subject to such Purchaser’s rights under this Section 2.1(a) being hereinafter referred to, subject to the provisions of Section 2.1(a)(iii) below, as such Purchaser’s “Second Tranche Individual Purchase Shares”), at a purchase price per share equal to the Series D Price.  The right of each Purchaser to purchase such Purchaser’s Second Tranche Individual Purchase Shares pursuant to this Section 2.1(a) shall be referred to in this Agreement as such Purchaser’s “Second Tranche Individual Purchase Right.”  Subject to the terms and conditions of this Agreement (including, without limitation, the terms and conditions set forth below in this Section 2.1(a)), each Purchaser may exercise such Purchaser’s Second Tranche Individual Purchase Right by delivering a written notice of exercise to the Company (a “Second Tranche Individual Purchase Exercise Notice”) setting forth a proposed date for the closing of such Purchaser’s Second Tranche Individual Purchase Right (such closing being referred to in this Agreement as a “Section 2.1(a) Closing”) that is consistent with the applicable requirements of Section 2.1(a)(ii) below.  If a Purchaser delivers to the Company a Second Tranche Individual Purchase Exercise Notice in accordance with the provisions of this Section 2.1(a)(i) and Section 2.1(a)(ii) below, then, subject to the terms and conditions of this Agreement (including, without limitation, the terms and conditions set forth below in this Section 2.1(a)), at the applicable Section 2.1(a) Closing, the Company shall issue and sell to such Purchaser, and such Purchaser shall purchase from the Company, all (but not less than all) of such Purchaser’s Second Tranche Individual Purchase Shares, at a purchase price per share equal to the Series D Price.

 

(ii)                                  Notwithstanding anything express or implied in the foregoing provisions of this Section 2.1(a) to the contrary:  (A) no Purchaser shall send the Second Tranche Individual Purchase Exercise Notice at any time during the Restricted Period; (B) the sale and purchase of any Purchaser’s Second Tranche Individual Purchase Shares

 

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pursuant to this Section 2.1(a) shall not be consummated at any time during the Restricted Period; and (C) in the event that the sale and purchase of a Purchaser’s Second Tranche Individual Purchase Shares pursuant to this Section 2.1(a) is to be consummated at any time within thirty (30) days prior to the consummation of a Deemed Liquidation Event or at any time after the closing of the IPO, such Purchaser shall have the right to make a Net Issue Election pursuant to which such Purchaser shall be issued pursuant to this Section 2.1(a), at the applicable Section 2.1(a) Closing, a smaller number of such Purchaser’s Second Tranche Individual Purchase Shares determined in accordance with such Net Issue Election and without having to make payment to the Company of any cash purchase price in connection with such smaller number of such Purchaser’s Second Tranche Individual Purchase Shares, in lieu of purchasing and paying the purchase price for the full number of such Purchaser’s Second Tranche Individual Purchase Shares that such Purchaser would otherwise purchase and pay for pursuant to this Section 2.1(a).

 

(iii)          In the event that (1) the Company consummates the IPO, (2) the sale and purchase of a Purchaser’s Second Tranche Individual Purchase Shares has not been consummated pursuant to this Section 2.1(a) prior to the closing of the IPO and (3) the rights and obligations of the Company and such Purchaser to consummate the sale and purchase of such Purchaser’s Second Tranche Individual Purchase Shares pursuant to this Section 2.1(a) have not terminated in accordance with Section 2.1(a)(iv) prior to the closing of the IPO, then upon the exercise by such Purchaser of such Purchaser’s Second Tranche Individual Purchase Right by sending such Purchaser’s Second Tranche Individual Purchase Notice in accordance with the provisions of this Section 2.1(a) at any time from and after the closing of the IPO, the Company shall issue and sell to such Purchaser, and such Purchaser shall purchase from the Company, in lieu of the number of shares of Series D Preferred Stock set forth opposite such Purchaser’s name under the heading “Second Tranche Shares” on Exhibit A, all (but not less than all) of that number of whole shares of Common Stock that is equal to (A) the quotient (rounded down to the nearest whole number) obtained by dividing (x) the total purchase price that such Purchaser would have been required to pay to the Company for the purchase pursuant to Section 2.1(a)(i) above of such number of shares of Series D Preferred Stock, by (y) the price per share at which the Company sold Common Stock to the public in the IPO, less (B)  the number of shares of Common Stock, if any, that are offered to such Purchaser for purchase in the IPO by the Company or the underwriters in connection with the IPO and that such Purchaser could have purchased in the IPO at the time of the closing of the IPO (regardless of whether or not such Purchaser actually purchases in the IPO such number of shares of Common Stock so offered and made available for purchase by such Purchaser at the time of the closing of the IPO); provided, however, that in no event shall such number of shares of Common Stock subject to purchase and sale pursuant to this Section 2.1(a)(iii) be less than zero.  The purchase price per share payable by such Purchaser to the Company for any shares of Common Stock sold and purchased pursuant to this Section 2.1(a)(iii) shall be the lower of (I) the Conversion Price (as defined in the Restated Certificate) per share of the Series D Preferred Stock immediately prior to the IPO and (II) the price per share at which the Company sold Common Stock to the public in the IPO.  Upon request by a Purchaser, the Company shall request from the underwriter or underwriters of the IPO written confirmation as to (x) the number of shares of Common Stock offered in connection with the IPO that such Purchaser could have purchased at the time of the closing of the IPO and (y) the number of shares of Common Stock that such Purchaser purchased in the IPO or entered into a legally binding agreement to purchase at the time of the closing of

 

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the IPO.  The Company shall provide to such Purchaser a copy of such written confirmation received from the underwriter or underwriters of the IPO.  From and after the closing of the IPO, any reference in this Agreement (including, without limitation, this Section 2.1(a)) to any Purchaser’s Second Tranche Individual Purchase Shares shall be a reference to the shares of Common Stock, if any, that the Company is required to issue and sell to such Purchaser, and such Purchaser is entitled to purchase from the Company, pursuant to this Section 2.1(a)(iii) upon the exercise by such Purchaser of such Purchaser’s Second Tranche Individual Purchase Right in accordance with the provisions of this Section 2.1(a), and such Purchaser’s Second Tranche Individual Purchase Shares shall no longer be a reference to the number of shares of Series D Preferred Stock set forth opposite such Purchaser’s name under the heading “Second Tranche Shares” on Exhibit A that the Company was required to issue and sell to such Purchaser, and such Purchaser had the right to purchase from the Company, pursuant to Section 2.1(a)(i) prior to the closing of the IPO.

 

(iv)                              The rights and obligations of the Company and each Purchaser to consummate the sale and purchase of such Purchaser’s Second Tranche Individual Purchase Shares pursuant to this Section 2.1(a) shall automatically terminate on the earlier of (1) the date of the Second Tranche Closing (if any), (2) the date of the Third Tranche Closing (if any), (3) the closing of the IPO if there are no shares of Common Stock that the Company is required to issue and sell to such Purchaser, and such Purchaser is entitled to purchase from the Company, pursuant to, and in accordance with, Section 2.1(a)(iii) hereof upon the exercise by such Purchaser of such Purchaser’s Second Tranche Individual Purchase Right at any time from and after the closing of the IPO, (4) the tenth (10th) anniversary of the Initial Tranche Closing and (5) the consummation of a Deemed Liquidation Event.  In addition, if a Purchaser is in material breach of any representation, warranty, covenant or provision under this Agreement that is applicable to such Purchaser (which material breach remains uncured for at least thirty (30) days after written notice thereof), then the obligation of the Company to consummate the sale of such Purchaser’s Second Tranche Individual Purchase Shares to such Purchaser pursuant to this Section 2.1(a), and the right of such Purchaser to consummate the purchase of such Purchaser’s Second Tranche Individual Purchase Shares from the Company pursuant to this Section 2.1(a), may be terminated by the Company by giving written notice of termination to such Purchaser.  Any termination pursuant to this Section 2.1(a)(iv) of the rights and/or obligations of the Company and/or any Purchaser to consummate the sale and purchase of such Purchaser’s Second Tranche Individual Purchase Shares pursuant to this Section 2.1(a) shall not relieve or release any party to this Agreement from any material breach by such party of any representation, warranty, covenant or provision under this Agreement that is applicable to such party if and to the extent that such material breach occurred prior to such termination.

 

(b)                                 Third Tranche Individual Purchase Right.

 

(i)                                     Subject to the terms and conditions of this Agreement (including, without limitation, the terms and conditions set forth below in this Section 2.1(b)), each Purchaser shall have the right under this Section 2.1(b) to purchase from the Company all (but not less than all) of the number of shares of Series D Preferred Stock set forth opposite such Purchaser’s name under the heading “Third Tranche Shares” on Exhibit A (such number of shares of Series D Preferred Stock subject to such Purchaser’s rights under this Section 2.1(b) being hereinafter referred to, subject to the provisions of Section 2.1(b)(iii) below, as such

 

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Purchaser’s “Third Tranche Individual Purchase Shares”), at a purchase price per share equal to the Series D Price.  The right of each Purchaser to purchase such Purchaser’s Third Tranche Individual Purchase Shares pursuant to this Section 2.1(b) shall be referred to in this Agreement as such Purchaser’s “Third Tranche Individual Purchase Right.”  Subject to the terms and conditions of this Agreement (including, without limitation, the terms and conditions set forth below in this Section 2.1(b)), each Purchaser may exercise such Purchaser’s Third Tranche Individual Purchase Right by delivering a written notice of exercise to the Company (a “Third Tranche Individual Purchase Exercise Notice”) setting forth a proposed date for the closing of such Purchaser’s Third Tranche Individual Purchase Right (such closing being referred to in this Agreement as a “Section 2.1(b) Closing”) that is consistent with the applicable requirements of Section 2.1(b)(ii) below.  If a Purchaser delivers to the Company a Third Tranche Individual Purchase Exercise Notice in accordance with the provisions of this Section 2.1(b)(i) and Section 2.1(b)(ii) below, then, subject to the terms and conditions of this Agreement (including, without limitation, the terms and conditions set forth below in this Section 2.1(b)), at the applicable Section 2.1(b) Closing, the Company shall issue and sell to such Purchaser, and such Purchaser shall purchase from the Company, all (but not less than all) of such Purchaser’s Third Tranche Individual Purchase Shares, at a purchase price per share equal to the Series D Price.  Notwithstanding anything express or implied in this Agreement to the contrary (including, without limitation, any of the foregoing provisions of this Section 2.1(b)(i)), if a Purchaser has not exercised such Purchaser’s Second Tranche Individual Purchase Right and consummated the sale and purchase of all of such Purchaser’s Second Tranche Individual Purchase Shares pursuant to Section 2.1(a) hereof and if such Purchaser’s Second Tranche Individual Purchaser Right has not terminated pursuant to, and in accordance with, the provisions of Section 2.1(a)(iv) hereof, then, simultaneously with such Purchaser’s exercise of such Purchaser’s Third Tranche Individual Purchase Right and the consummation of the sale and purchase of all of such Purchaser’s Third Tranche Individual Purchase Shares pursuant to, and in accordance with, this Section 2.1(b), such Purchaser shall be obligated to exercise such Purchaser’s Second Tranche Individual Purchase Right and to consummate the sale and purchase of all of such Purchaser’s Second Tranche Individual Purchase Shares pursuant to, and in accordance with, the provisions of Section 2.1(a) hereof.

 

(ii)                                  Notwithstanding anything express or implied in the foregoing provisions of this Section 2.1(b) to the contrary:  (A) no Purchaser shall send the Third Tranche Individual Purchase Exercise Notice at any time during the Restricted Period; (B) the sale and purchase of any Purchaser’s Third Tranche Individual Purchase Shares pursuant to this Section 2.1(b) shall not be consummated at any time during the Restricted Period; and (C) in the event that the sale and purchase of a Purchaser’s Third Tranche Individual Purchase Shares pursuant to this Section 2.1(b) is to be consummated at any time within thirty (30) days prior to the consummation of a Deemed Liquidation Event or at any time after the closing of the IPO, such Purchaser shall have the right to make a Net Issue Election pursuant to which such Purchaser shall be issued pursuant to this Section 2.1(b), at the applicable Section 2.1(b) Closing, a smaller number of such Purchaser’s Third Tranche Individual Purchase Shares determined in accordance with such Net Issue Election and without having to make payment to the Company of any cash purchase price in connection with such smaller number of such Purchaser’s Third Tranche Individual Purchase Shares, in lieu of purchasing and paying the purchase price for the full number of such Purchaser’s Third Tranche Individual Purchase Shares that such Purchaser would otherwise purchase and pay for pursuant to this Section 2.1(b).

 

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(iii)                               In the event that (1) the Company consummates the IPO, (2) the sale and purchase of a Purchaser’s Third Tranche Individual Purchase Shares has not been consummated pursuant to this Section 2.1(b) prior to the closing of the IPO and (3) the rights and obligations of the Company and such Purchaser to consummate the sale and purchase of such Purchaser’s Third Tranche Individual Purchase Shares pursuant to this Section 2.1(b) have not terminated in accordance with Section 2.1(b)(iv) prior to the closing of the IPO, then upon the exercise by such Purchaser of such Purchaser’s Third Tranche Individual Purchase Right by sending such Purchaser’s Third Tranche Individual Purchase Notice in accordance with the provisions of this Section 2.1(b) at any time from and after the closing of the IPO, the Company shall issue and sell to such Purchaser, and such Purchaser shall purchase from the Company, in lieu of the number of shares of Series D Preferred Stock set forth opposite such Purchaser’s name under the heading “Third Tranche Shares” on Exhibit A, all (but not less than all) of that number of whole shares of Common Stock that is equal to (A) the quotient (rounded down to the nearest whole number) obtained by dividing (x) the total purchase price that such Purchaser would have been required to pay to the Company for the purchase pursuant to Section 2.1(b)(i) above of such number of shares of Series D Preferred Stock, by (y) the price per share at which the Company sold Common Stock to the public in the IPO, less (B)  the number of shares of Common Stock, if any, that are offered to such Purchaser for purchase in the IPO by the Company or the underwriters in connection with the IPO and that such Purchaser could have purchased in the IPO at the time of the closing of the IPO (regardless of whether or not such Purchaser actually purchases in the IPO such number of shares of Common Stock so offered and made available for purchase by such Purchaser at the time of the closing of the IPO); provided, however, that (i) the reduction or deduction pursuant to the foregoing clause (B) shall be implemented only to the extent that the shares of Common Stock referred to in such clause (B) have not been taken into account to effect a reduction or deduction pursuant clause (B) of Section 2.1(a)(iii) hereof and (ii) in no event shall the number of shares of Common Stock subject to purchase and sale pursuant to this Section 2.1(b)(iii) be less than zero.  The purchase price per share payable by such Purchaser to the Company for any shares of Common Stock sold and purchased pursuant to this Section 2.1(b)(iii) shall be the lower of (I) the Conversion Price (as defined in the Restated Certificate) per share of the Series D Preferred Stock immediately prior to the IPO and (II) the price per share at which the Company sold Common Stock to the public in the IPO.  Upon request by a Purchaser, the Company shall request from the underwriter or underwriters of the IPO written confirmation as to (x) the number of shares of Common Stock offered in connection with the IPO that such Purchaser could have purchased at the time of the closing of the IPO and (y) the number of shares of Common Stock that such Purchaser purchased in the IPO or entered into a legally binding agreement to purchase at the time of the closing of the IPO.  The Company shall provide to such Purchaser a copy of such written confirmation received from the underwriter or underwriters of the IPO.  From and after the closing of the IPO, any reference in this Agreement (including, without limitation, this Section 2.1(b)) to any Purchaser’s Third Tranche Individual Purchase Shares shall be a reference to the shares of Common Stock, if any, that the Company is required to issue and sell to such Purchaser, and such Purchaser is entitled to purchase from the Company, pursuant to this Section 2.1(b)(iii) upon the exercise by such Purchaser of such Purchaser’s Third Tranche Individual Purchase Right in accordance with the provisions of this Section 2.1(b), and such Purchaser’s Third Tranche Individual Shares shall no longer be a reference to the number of shares of Series D Preferred Stock set forth opposite such Purchaser’s name under the heading “Third Tranche

 

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Shares” on Exhibit A that the Company was required to issue and sell to such Purchaser, and such Purchaser had the right to purchase from the Company, pursuant to Section 2.1(b)(i) prior to the closing of the IPO.

 

(iv)                              The rights and obligations of the Company and each Purchaser to consummate the sale and purchase of such Purchaser’s Third Tranche Individual Purchase Shares pursuant to this Section 2.1(b) shall automatically terminate on the earlier of (1) the date of the Third Tranche Closing (if any), (2) the closing of the IPO if there are no shares of Common Stock that the Company is required to issue and sell to such Purchaser, and such Purchaser is entitled to purchase from the Company, pursuant to, and in accordance with, Section 2.1(b)(iii) hereof upon the exercise by such Purchaser of such Purchaser’s Third Tranche Individual Purchase Right at any time from and after the closing of the IPO, (3) the tenth (10th) anniversary of the Initial Tranche Closing and (4) the consummation of a Deemed Liquidation Event.  In addition, if a Purchaser is in material breach of any representation, warranty, covenant or provision under this Agreement that is applicable to such Purchaser (which material breach remains uncured for at least thirty (30) days after written notice thereof), then the obligation of the Company to consummate the sale of such Purchaser’s Third Tranche Individual Purchase Shares to such Purchaser pursuant to this Section 2.1(b), and the right of such Purchaser to consummate the purchase of such Purchaser’s Third Tranche Individual Purchase Shares from the Company pursuant to this Section 2.1(b), may be terminated by the Company by giving written notice of termination to such Purchaser.  Any termination pursuant to this Section 2.1(b)(iv) of the rights and/or obligations of the Company and/or any Purchaser to consummate the sale and purchase of such Purchaser’s Third Tranche Individual Purchase Shares pursuant to this Section 2.1(b) shall not relieve or release any party to this Agreement from any material breach by such party of any representation, warranty, covenant or provision under this Agreement that is applicable to such party if and to the extent that such material breach occurred prior to such termination.

 

2.2.                            Closings; Delivery.

 

(a)                                 Second Tranche Individual Purchase Right Closings.

 

(i)                                     The closing of the purchase and sale of a Purchaser’s Second Tranche Individual Purchase Shares pursuant to Section 2.1(a) hereof shall take place remotely via the exchange of documents and signatures on either the date specified in such Purchaser’s Second Tranche Individual Purchase Exercise Notice delivered pursuant to Section 2.1(a)(i) hereof, which date specified must be consistent with the applicable requirements of Section 2.1(a)(ii), or on such other date as the Company and such Purchaser mutually agree (such closing, a “Section 2.1(a) Closing”).

 

(ii)                                  At each Section 2.1(a) Closing, the Company shall deliver to the Purchaser participating in such Section 2.1(a) Closing a certificate representing such Purchaser’s Second Tranche Individual Purchase Shares, against either (1) payment by such Purchaser of the purchase price for such Purchaser’s Second Tranche Individual Purchase Shares by check payable to the Company, by wire transfer to a bank account designated by the Company or by any combination of such methods or (2) delivery by such Purchaser of a Net Issue Election Form that has been properly completed and duly executed by such Purchaser if

 

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such Purchaser is entitled to make a Net Issue Election pursuant to Section 2.1(a)(ii) in connection with the purchase of such Purchaser’s Second Tranche Individual Purchase Shares at such Section 2.1(a) Closing.

 

(b)                                 Third Tranche Individual Purchase Right Closings.

 

(i)                                     The closing of the purchase and sale of a Purchaser’s Third Tranche Individual Purchase Shares pursuant to Section 2.1(b) hereof shall take place remotely via the exchange of documents and signatures on either the date specified in such Purchaser’s Third Tranche Individual Purchase Exercise Notice delivered pursuant to Section 2.1(b)(i) hereof, which date specified must be consistent with the applicable requirements of Section 2.1(b)(ii), or on such other date as the Company and such Purchaser mutually agree (such closing, a “Section 2.1(b) Closing”).

 

(ii)                                  At each Section 2.1(b) Closing, the Company shall deliver to the Purchaser participating in such Section 2.1(b) Closing a certificate representing such Purchaser’s Third Tranche Individual Purchase Shares, against either (1) payment by such Purchaser of the purchase price for such Purchaser’s Third Tranche Individual Purchase Shares by check payable to the Company, by wire transfer to a bank account designated by the Company or by any combination of such methods or (2) delivery by such Purchaser of a Net Issue Election Form that has been properly completed and duly executed by such Purchaser if such Purchaser is entitled to make a Net Issue Election pursuant to Section 2.1(b)(ii) in connection with the purchase of such Purchaser’s Third Tranche Individual Purchase Shares at such Section 2.1(b) Closing.

 

3.                                      Representations and Warranties of the Company.  The Company hereby represents and warrants to each Purchaser that, except as set forth on the Disclosure Schedule attached as Exhibit C to this Agreement (as updated by the Updated Disclosure Schedule pursuant to Section 1.3), which exceptions shall be deemed to be a part of the representations and warranties made hereunder, the following representations are true and complete as of the date of the hereof and as of the applicable Closing (unless the particular statement speaks expressly as of another date, in which case as of such other date).

 

The Disclosure Schedule (including each update thereto) shall be arranged in sections corresponding to the numbered and lettered sections and subsections contained in this Section 3, and the disclosures in any section or subsection of the Disclosure Schedule shall qualify other sections and subsections in this Section only to the extent it is readily apparent from a reading of the disclosure that such disclosure is applicable to such other sections and subsections.  For purposes of these representations and warranties (other than those in Sections 3.2, 3.3, 3.4, 3.5 and 3.6), the term “the Company” shall include any subsidiaries of the Company unless otherwise noted herein:

 

3.1.                            Organization, Good Standing, Corporate Power and Qualification.  The Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware and has all requisite corporate power and authority to carry on its business as presently conducted and as proposed to be conducted.  The Company is duly qualified to transact business and is in good standing in the State of Missouri, Commonwealth of

 

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Massachusetts and in each other jurisdiction in which the failure to so qualify would have a Material Adverse Effect.

 

3.2.                            Capitalization.

 

(a)                                 (i) Immediately prior to the Initial Tranche Closing after giving effect to the filing of the Restated Certificate with the Secretary of State of the State of Delaware, the authorized capital of the Company consists of:  (i) 205,926,290 shares of Common Stock, of which 3,833,606 shares are issued and outstanding, (ii) 158,642,302 shares of Preferred Stock, of which (A) 22,638,465 shares are designated Series A Preferred Stock and are issued and outstanding, (B) 10,909,091 shares are designated Series A-1 Preferred Stock and are issued and outstanding, (C) 20,754,461 shares are designated as Series B Preferred Stock and are issued and outstanding, (D) 17,550,758 shares are designated as Series C Preferred Stock, of which 13,202,932 shares are issued and outstanding and (E) 86,789,527 shares are designated as Series D Preferred Stock, none of which are issued and outstanding.  At the time of the Closing, (i) all of the outstanding shares of Common Stock and Preferred Stock will have been duly authorized, will be fully paid and nonassessable and will have been issued in compliance with all applicable federal and state securities laws; (ii) the Company will hold no shares of Common Stock or Preferred Stock in its treasury; and (iii) the rights, privileges and preferences of the Preferred Stock will be as stated in the Restated Certificate and as provided by the General Corporation Law of the State of Delaware.

 

(b)                                 As of immediately prior to the Initial Tranche Closing, The Company has reserved 18,222,157 shares of Common Stock for issuance to officers, directors, employees and consultants of the Company pursuant to its 2006 Equity Incentive Plan duly adopted by the Board of Directors and approved by the Company stockholders (as amended and in effect from time to time, the “Stock Plan”).  Of such reserved shares, options to purchase 9,607,120 shares are currently outstanding, 221,676 shares have been issued upon exercise and 8,393,361 shares remain available for issuance to officers, directors, employees and consultants pursuant to the Stock Plan.  The Company has furnished to the Purchasers complete and accurate copies of the Stock Plan and forms of agreements used thereunder.

 

(c)                                  Section 3.2(c) of the Disclosure Schedule sets forth the capitalization of the Company immediately prior to the Initial Tranche Closing including the number of shares of the following: (i) issued and outstanding Common Stock, including, with respect to restricted Common Stock, if any, vesting schedule and repurchase price; (ii) issued stock options, if any; (iii) stock options, if any, not yet issued but reserved for issuance, including vesting schedule and exercise price; (iv) each series of Preferred Stock; and (v) warrants or stock purchase rights, if any. Except for (A) the conversion privileges of the Preferred Stock, (B) the rights provided in Section 5 of the Investors’ Rights Agreement, and (C) the securities and rights described in Sections 3.2(a) and 3.2(b) of this Agreement and Section 3.2(c) of the Disclosure Schedule, there are no outstanding options, warrants (other than warrants to purchase Common Stock, issued pursuant to that certain Series C Preferred Stock Purchase Agreement, dated as of August 2, 2011, by and among the Company and the investors named therein, as amended), rights (including conversion or preemptive rights and rights of first refusal or similar rights) or agreements, orally or in writing, to purchase or acquire from the Company any shares of Common Stock or Preferred Stock, or any securities convertible into or exchangeable for shares

 

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of Common Stock or Preferred Stock.  Outstanding shares of the Company’s Common Stock and shares of the Company’s Common Stock underlying outstanding options that, in each case, are held by holders that hold 1% or more of the Company’s then outstanding capital stock (treating for this purpose all shares of Common Stock issuable upon exercise or conversion of outstanding options, warrants or convertible securities, as if exercised and/or converted), if any, are subject to (i) a right of first refusal in favor of the Company upon any proposed transfer (other than transfers for estate planning purposes); and (ii) a lock-up or market standoff agreement of not less than 180 days following the IPO.

 

(d)                                 None of the Company’s stock purchase agreements or stock option documents contains a provision for acceleration of vesting (or lapse of a repurchase right) or other changes in the vesting provisions or other terms of such agreement or understanding upon the occurrence of any event or combination of events.  The Company has never adjusted or amended the exercise price of any stock options previously awarded, whether through amendment, cancellation, replacement grant, repricing, or any other means.  No stock options, stock appreciation rights or other equity-based awards issued or granted by the Company are subject to the requirements of Section 409A of the Code.  Except as set forth in the Restated Certificate, the Company has no obligation (contingent or otherwise) to purchase or redeem any of its capital stock.

 

3.3.                            Subsidiaries.  The Company does not currently own or control, directly or indirectly, any interest in any other corporation, partnership, trust, joint venture, limited liability company, association, or other business entity.  The Company is not a participant in any joint venture, partnership or similar arrangement.

 

3.4.                            Authorization.  All corporate action required to be taken by the Company’s Board of Directors and stockholders in order to authorize the Company to enter into the Transaction Agreements, and to issue the Shares pursuant to this Agreement and the Common Stock issuable upon conversion of the Series D Preferred Stock issued pursuant to this Agreement, has been taken or will be taken prior to the Initial Tranche Closing.  All action on the part of the officers of the Company necessary for the execution and delivery of the Transaction Agreements, the performance of all obligations of the Company under the Transaction Agreements and the issuance and delivery of the Shares has been taken or will be taken prior to the Initial Tranche Closing.  The Transaction Agreements, when executed and delivered by the Company, shall constitute valid and legally binding obligations of the Company, enforceable against the Company in accordance with their respective terms except (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance, or other laws of general application relating to or affecting the enforcement of creditors’ rights generally, (ii) as limited by laws relating to the availability of specific performance, injunctive relief, or other equitable remedies, or (iii) to the extent the indemnification provisions contained in the Investors’ Rights Agreement may be limited by applicable federal or state securities laws.

 

3.5.                            Valid Issuance of Shares.  The Shares, when issued, sold and delivered in accordance with the terms and for the consideration set forth in this Agreement, will be validly issued, fully paid and nonassessable and free of restrictions on transfer other than restrictions on transfer under the Transaction Agreements, applicable state and federal securities laws and liens or encumbrances created by or imposed by a Purchaser.  Assuming the accuracy of the

 

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representations of the Purchasers in Section 4 of this Agreement and subject to the filings described in Section 3.6(ii) below, the Shares will be issued in compliance with all applicable federal and state securities laws.  The Common Stock issuable upon conversion of the Series D Preferred Stock issued pursuant to this Agreement have been duly reserved for issuance, and upon issuance in accordance with the terms of the Restated Certificate, will be validly issued, fully paid and nonassessable and free of restrictions on transfer other than restrictions on transfer under the Transaction Agreements, applicable federal and state securities laws and liens or encumbrances created by or imposed by a Purchaser.  Based in part upon the representations of the Purchasers in Section 4 of this Agreement, and subject to Section 3.6 below, the Common Stock issuable upon conversion of the Series D Preferred Stock issued pursuant to this Agreement will be issued in compliance with all applicable federal and state securities laws.

 

3.6.                            Governmental Consents and Filings.  Assuming the accuracy of the representations made by the Purchasers in Section 4 of this Agreement, no consent, approval, order or authorization of, or registration, qualification, designation, declaration or filing with, any federal, state or local governmental authority is required on the part of the Company in connection with the consummation of the transactions contemplated by this Agreement, except for (i) the filing of the Restated Certificate, and (ii) filings pursuant to Regulation D of the Securities Act, and applicable state securities laws, which have been made or will be made in a timely manner.

 

3.7.                            Litigation.  There is no claim, action, suit, proceeding, arbitration, complaint, charge or investigation pending or, to the Company’s knowledge, currently threatened (i) against the Company, or to the Company’s knowledge, any officer, director, consultant or Key Employee of the Company or (ii) that questions the validity of the Transaction Agreements or the right of the Company to enter into them, or to consummate the transactions contemplated by the Transaction Agreements.  Neither the Company nor, to the Company’s knowledge, any of its officers or directors, is a party or is named as subject to the provisions of any order, writ, injunction, judgment or decree of any court or government agency or instrumentality (in the case of officers or directors, such as would have a Material Adverse Effect on the Company).  There is no action, suit, proceeding or investigation by the Company pending or which the Company intends to initiate.  The foregoing includes, without limitation, actions, suits, proceedings or investigations pending or threatened in writing (or any basis therefor known to the Company) involving the prior employment of any of the Company’s employees, their services provided in connection with the Company’s business, or any information or techniques allegedly proprietary to any of their former employers, or their obligations under any agreements with prior employers.

 

3.8.                            Intellectual Property.

 

(a)                                 The Company owns or possesses sufficient legal rights to all Company Intellectual Property without, to the Company’s knowledge, any conflict with, or infringement of, the rights of others.  To the Company’s knowledge, no product or service marketed or sold (or proposed to be marketed or sold) by the Company violates or will violate any license or infringes or will infringe any Intellectual Property Rights of any other party, except as indicated in Section 3.8.5 of the Disclosure Schedule.

 

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(b)                                 Other than the inventions made by F. Nicholas Franano that are the subject of the JHU Assignment Documents identified in Section 3.8.9 of the Disclosure Schedule, and subject to Section 3.8.10 of the Disclosure Schedule, the Company has not developed or invented any Company Intellectual Property using any government funding or third party grant funding

 

(c)                                  Other than with respect to (i) commercially available software products under standard end-user object code license agreements, (ii) the agreement between Johns Hopkins University and Nicholas Franano, dated February 4, 2002, which agreement subsequently was assigned by Franano to Company, and (iii) U. S. government rights pursuant to the Bayh-Dole Act, and subject to Sections 3.8.7, 3.8.9(a) and 3.8.9(d) of the Disclosure Schedule, there are no outstanding options, licenses, agreements, claims, encumbrances of any kind relating to the Company Intellectual Property, nor is the Company bound by or a party to any options, licenses or agreements of any kind with respect to the Intellectual Property Rights of any other Person.  In addition, there are no shared ownership interests of any kind relating to the Company Intellectual Property identified in Sections 3.8.1 through 3.8.4 of the Disclosure Schedule.

 

(d)                                 The Company has not received any communications alleging that the Company has violated or, by conducting its business, would violate any of the Intellectual Property Rights of any other Person.

 

(e)                                  The Company has obtained and possesses valid licenses to use all of the software programs present on the computers and other software-enabled electronic devices that it owns or leases or that it has otherwise provided to its employees for their use in connection with the Company’s business.

 

(f)                                   To the Company’s knowledge, the Company’s business as presently conducted, or as is currently planned to be conducted, does not and will not use any inventions of any of its employees or consultants (or Persons it currently intends to hire) made prior to their employment by the Company other than the inventions made by F. Nicholas Franano that are the subject of the JHU Assignment Documents as set forth in Section 3.8.9 of the Disclosure Schedule.  Each Key Employee has assigned to the Company all patents, patent applications, and other Intellectual Property Rights he or she owns that are related to the Company’s business as now conducted and as presently proposed to be conducted.  Each employee and consultant has assigned to the Company all patents, patent applications, and other Intellectual Property Rights he or she owns that were developed by such person within the scope of his/her employment.

 

(g)                                  Sections 3.8.1 through 3.8.4 of the Disclosure Schedule list all registered Intellectual Property owned by the Company; the Company is the sole owner of such registered Intellectual Property; except as indicated in Section 3.8.1 of the Disclosure Schedule all necessary registration, maintenance, annuity and renewal fees currently due in connection with such registered Intellectual Property have been paid and all necessary documents and certificates in connection with such registered Intellectual Property have been filed with the relevant patent, copyright, trademark or other authorities in the United States or foreign jurisdictions, as the case may be, for the purposes of maintaining such registered Intellectual

 

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Property; and each patent application included in such registered Intellectual Property that has issued as a patent or is currently pending has been prosecuted in accordance with applicable law.

 

(h)                                 The Company has not embedded any open source, copyleft or community source code in any of its products generally available or in development, including but not limited to any libraries or code licensed under any General Public License, Lesser General Public License or similar license arrangement.

 

(i)                                     For purposes of this Section 3.8, the Company shall be deemed to have knowledge of a patent right if the Company has actual knowledge of the patent right or would be found to be on notice of such patent right for the purposes of willful infringement as determined by reference to United States patent laws.

 

3.9.                            Compliance with Other Instruments.  The Company is not in violation or default (i) of any provisions of its Restated Certificate or Bylaws, (ii) of any instrument, judgment, order, writ or decree, (iii) under any note, indenture or mortgage, or (iv) under any lease, agreement, contract or purchase order to which it is a party or by which it is bound that is required to be listed on the Disclosure Schedule, or of any provision of federal or state statute, rule or regulation applicable to the Company, the violation of which would have a Material Adverse Effect.  The execution, delivery and performance of the Transaction Agreements and the consummation of the transactions contemplated by the Transaction Agreements will not result in any such violation or be in conflict with or constitute, with or without the passage of time and giving of notice, either (i) a default under any such provision, instrument, judgment, order, writ, decree, contract or agreement or (ii) an event which results in the creation of any lien, charge or encumbrance upon any assets of the Company (other than any lien, charge, or encumbrance contemplated or created by the terms of the Option Agreement) or the suspension, revocation, forfeiture, or nonrenewal of any material permit or license applicable to the Company.

 

3.10.                     Agreements; Actions.

 

(a)                                 Except for the Transaction Agreements or the Option Agreement, there are no agreements, understandings, instruments, contracts or proposed transactions to which the Company is a party or by which it is bound that involve (i) obligations (contingent or otherwise) of, or payments to, the Company in excess of $50,000 per annum, (ii) the license of any patent, copyright, trademark, trade secret or other proprietary right to or from the Company, (iii) the grant of rights to manufacture, produce, assemble, license, market, or sell its products to any other Person that limit the Company’s exclusive right to develop, manufacture, assemble, distribute, market or sell its products, or (iv) indemnification by the Company with respect to infringements of proprietary rights.

 

(b)                                 The Company has not (i) declared or paid any dividends, or authorized or made any distribution upon or with respect to any class or series of its capital stock, (ii) incurred any indebtedness for money borrowed or incurred any other liabilities individually in excess of $50,000 per annum or in excess of $100,000 in the aggregate, (iii) made any loans or advances to any Person, other than ordinary advances for travel expenses, or (iv) sold, exchanged or otherwise disposed of any of its assets or rights, other than the sale of its

 

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inventory in the ordinary course of business.  For the purposes of subsections (b) and (c) of this Section 3.10, all indebtedness, liabilities, agreements, understandings, instruments, contracts and proposed transactions involving the same Person (including Persons the Company has reason to believe are affiliated with each other) shall be aggregated for the purpose of meeting the individual minimum dollar amounts of such subsection.

 

(c)                                  The Company is not a guarantor or indemnitor of any indebtedness of any other Person.

 

(d)                                 Novartis’ option to acquire the Company, granted to Novartis under the Option Agreement and that certain Agreement and Plan of Merger, dated as of February 27, 2009, by and among the Company and Novartis, Novartis PR Sub, Inc. and the Stockholders’ Representative referenced therein, terminated on August 3, 2013, and the Company has provided Ropes & Gray LLP with all correspondence in the Company’s possession regarding the termination thereof.  The transactions contemplated by the Transaction Agreements do not constitute an Acquisition Proposal as defined under and for purposes of the Option Agreement.

 

3.11.                     Certain Transactions.

 

(a)                                 Other than (i) standard employee benefits generally made available to all employees, (ii) standard director and officer indemnification agreements approved by the Board of Directors, and (iii) the purchase of shares of the Company’s capital stock and the issuance of options to purchase shares of the Company’s Common Stock, in each instance, approved in the written minutes of the Board of Directors (previously provided to the Purchasers or their counsel), there are no agreements, understandings or proposed transactions between the Company and any of its officers, directors, consultants, or Key Employees, or any Affiliate thereof.

 

(b)                                 The Company is not indebted, directly or indirectly, to any of its directors, officers or employees or to their respective spouses or children or to any Affiliate of any of the foregoing, other than in connection with expenses or advances of expenses incurred in the ordinary course of business or employee relocation expenses and for other customary employee benefits made generally available to all employees.  None of the Company’s directors, officers or employees, or any members of their immediate families, or any Affiliate of the foregoing (i) are, directly or indirectly, indebted to the Company or, (ii) to the Company’s knowledge, have any direct or indirect ownership interest in any firm or corporation with which the Company is affiliated or with which the Company has a business relationship, or any firm or corporation which competes with the Company except that directors, officers or employees or stockholders of the Company may own stock in (but not exceeding two percent (2%) of the outstanding capital stock of) publicly traded companies that may compete with the Company.  None of the Company’s Key Employees or directors or any members of their immediate families or any Affiliate of any of the foregoing are, directly or indirectly, interested in any contract with the Company.  None of the directors or officers, or any members of their immediate families, has any material commercial, industrial, banking, consulting, legal, accounting, charitable or familial relationship with any of the Company’s customers, suppliers, service providers, joint venture partners, licensees and competitors.

 

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3.12.                     Rights of Registration and Voting Rights.  Except as provided in the Investors’ Rights Agreement, the Company is not under any obligation to register under the Securities Act any of its currently outstanding securities or any securities issuable upon exercise or conversion of its currently outstanding securities.  To the Company’s knowledge, except as contemplated in the Voting Agreement, no stockholder of the Company has entered into any agreements with respect to the voting of capital shares of the Company.

 

3.13.                     Absence of Liens.  The property and assets that the Company owns are free and clear of all mortgages, deeds of trust, liens, loans and encumbrances, except for any encumbrances contemplated or created by the terms of the Option Agreement and except for any statutory liens for the payment of current taxes that are not yet delinquent and encumbrances and liens that arise in the ordinary course of business and do not materially impair the Company’s ownership or use of such property or assets.  With respect to the property and assets it leases, the Company is in compliance with such leases and, to its knowledge, holds a valid leasehold interest free of any liens, claims or encumbrances other than those of the lessors of such property or assets.

 

3.14.                     Financial Statements.  The Company has delivered to each Purchaser the Company’s audited financial statements as of December 31, 2012 and for the fiscal year then ended and its unaudited financial statements (including balance sheet, income statement and statement of cash flows) as of December 31, 2013 and for the fiscal year then ended and its unaudited financial statements (including balance sheet, income statement and statement of cash flows) as of March 31, 2014 (the “Balance Sheet Date”) and for the three-month period then ended (collectively, the “Financial Statements”).  The Financial Statements have been prepared in accordance with generally accepted accounting principles applied on a consistent basis throughout the periods indicated, except that the unaudited Financial Statements may not contain all footnotes required by generally accepted accounting principles.  The Financial Statements fairly present in all material respects the financial condition and operating results of the Company as of the dates, and for the periods, indicated therein, subject in the case of the unaudited Financial Statements to normal year-end audit adjustments and the omitted footnote disclosures.  Except as set forth in the Financial Statements, the Company has no material liabilities or obligations, contingent or otherwise, other than (i) liabilities incurred in the ordinary course of business subsequent to the Balance Sheet Date and (ii) liabilities and obligations under contracts and commitments incurred in the ordinary course of business and of a type or nature not required under generally accepted accounting principles to be reflected in the Financial Statements, which, in all such cases, individually and in the aggregate would not have a Material Adverse Effect.  The Company maintains and will continue to maintain a standard system of accounting established and administered in accordance with generally accepted accounting principles.

 

3.15.                     Changes.  Since the Balance Sheet Date there has not been:

 

(a)                                 any change in the assets, liabilities, financial condition or operating results of the Company from that reflected in the Financial Statements, except changes in the ordinary course of business that have not caused, in the aggregate, a Material Adverse Effect;

 

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(b)                                 any damage, destruction or loss, whether or not covered by insurance, that would have a Material Adverse Effect;

 

(c)                                  any waiver or compromise by the Company of a valuable right or of a material debt owed to it;

 

(d)                                 any satisfaction or discharge of any lien, claim, or encumbrance or payment of any obligation by the Company, except in the ordinary course of business and the satisfaction or discharge of which would not have a Material Adverse Effect;

 

(e)                                  any material change to a material contract or agreement by which the Company or any of its assets is bound or subject;

 

(f)                                   any material change in any compensation arrangement or agreement with any employee, officer, director or stockholder;

 

(g)                                  any resignation or termination of employment of any officer or Key Employee of the Company, or of a consultant of the Company that would have a Material Adverse Effect;

 

(h)                                 any mortgage, pledge, transfer of a security interest in, or lien, created by the Company, with respect to any of its material properties or assets, except liens for taxes not yet due or payable and liens that arise in the ordinary course of business and do not materially impair the Company’s ownership or use of such property or assets and except for any encumbrances contemplated or created by the terms of the Option Agreement;

 

(i)                                     any loans or guarantees made by the Company to or for the benefit of its employees, officers or directors, or any members of their immediate families, other than travel advances and other advances made in the ordinary course of its business;

 

(j)                                    any declaration, setting aside or payment or other distribution in respect of any of the Company’s capital stock, or any direct or indirect redemption, purchase, or other acquisition of any of such stock by the Company;

 

(k)                                 any sale, assignment or transfer of any Company Intellectual Property that could reasonably be expected to result in a Material Adverse Effect;

 

(l)                                     receipt of notice that there has been a loss of, or material order cancellation by, any major customer of the Company;

 

(m)                             to the Company’s knowledge, any other event or condition of any character, other than events affecting the economy or the Company’s industry generally,  that could reasonably be expected to result in a Material Adverse Effect; or

 

(n)                                 any arrangement or commitment by the Company to do any of the things described in this Section 3.15.

 

3.16.                     Employee Matters.

 

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(a)                                 The Company has provided to the Major Investors a written description of all compensation, including salary, bonus, severance obligations and deferred compensation paid or payable for each officer, employee, consultant and independent contractor of the Company who received compensation in excess of $100,000 for the fiscal year ended December 31, 2013 or is anticipated to receive compensation in excess of $100,000 for the fiscal year ending December 31, 2014.

 

(b)                                 To the Company’s knowledge, none of its employees is obligated under any contract (including licenses, covenants or commitments of any nature) or other agreement, or subject to any judgment, decree or order of any court or administrative agency, that would materially interfere with such employee’s ability to promote the interest of the Company or that would conflict with the Company’s business.  Neither the execution or delivery of the Transaction Agreements, nor the carrying on of the Company’s business by the employees of the Company, nor the conduct of the Company’s business as now conducted and as presently proposed to be conducted, will, to the Company’s knowledge, conflict with or result in a breach of the terms, conditions, or provisions of, or constitute a default under, any contract, covenant or instrument under which any such employee is now obligated.

 

(c)                                  The Company is not delinquent in payments to any of its employees, consultants, or independent contractors for any wages, salaries, commissions, bonuses, or other direct compensation for any service performed for it or amounts required to be reimbursed to such employees, consultants, or independent contractors.  The Company has complied in all material respects with all applicable state and federal equal employment opportunity laws and with other laws related to employment, including those related to wages, hours, worker classification, and collective bargaining.  The Company has withheld and paid to the appropriate governmental entity or is holding for payment not yet due to such governmental entity all amounts required to be withheld from employees of the Company and is not liable for any arrears of wages, taxes, penalties, or other sums for failure to comply with any of the foregoing.

 

(d)                                 To the Company’s knowledge, no Key Employee or consultants of the Company intends to terminate employment with the Company or is otherwise likely to become unavailable to continue as a Key Employee or consultant, nor does the Company have a present intention to terminate the employment of any of the foregoing.  The employment of each employee of the Company is terminable at the will of the Company.  Except as set forth in Section 3.16(d) of the Disclosure Schedule or as required by law, upon termination of the employment of any such employees, no severance or other payments will become due.  Except as set forth in Section 3.16(d) of the Disclosure Schedule, the Company has no policy, practice, plan, or program of paying severance pay or any form of severance compensation in connection with the termination of employment services.

 

(e)                                  The Company has not made any representations regarding equity incentives to any officer, employees, director or consultant that are inconsistent with the share amounts and terms set forth in the Company’s board minutes.

 

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(f)                                   Each former Key Employee whose employment was terminated by the Company has entered into an agreement with the Company providing for the full release of any claims against the Company or any related party arising out of such employment.

 

(g)                                  Section 3.16(g) of the Disclosure Schedule lists each employee benefit plan maintained, established or sponsored by the Company, or which the Company participates in or contributes to, which is subject to the Employee Retirement Income Security Act of 1974, as amended (“ERISA”).  The Company has made all required contributions and has no liability to any such employee benefit plan, other than liability for health plan continuation coverage described in Part 6 of Title I(B) of ERISA,  and has complied in all material respects with all applicable laws for any such employee benefit plan.

 

(h)                                 The Company is not bound by or subject to (and none of its assets or properties is bound by or subject to) any written or oral, express or implied, contract, commitment or arrangement with any labor union, and no labor union has requested or, to the knowledge of the Company, has sought to represent any of the employees, representatives or agents of the Company.  There is no strike or other labor dispute involving the Company pending, or to the Company’s knowledge, threatened, which could have a Material Adverse Effect, nor is the Company aware of any labor organization activity involving its employees.

 

(i)                                     To the Company’s knowledge, none of the Key Employees or directors of the Company has been (i) subject to voluntary or involuntary petition under the federal bankruptcy laws or any state insolvency law or the appointment of a receiver, fiscal agent or similar officer by a court for his business or property; (ii) convicted in a criminal proceeding or named as a subject of a pending criminal proceeding (excluding traffic violations and other minor offenses); (iii) subject to any order, judgment, or decree (not subsequently reversed, suspended, or vacated) of any court of competent jurisdiction permanently or temporarily enjoining him from engaging, or otherwise imposing limits or conditions on his engagement in any securities, investment advisory, banking, insurance, or other type of business or acting as an officer or director of a public company; or (iv) found by a court of competent jurisdiction in a civil action or by the Securities and Exchange Commission or the Commodity Futures Trading Commission to have violated any federal or state securities, commodities, or unfair trade practices law, which such judgment or finding has not been subsequently reversed, suspended, or vacated.

 

3.17.                     Tax Returns and Payments.  There are no federal, state, county, local or foreign taxes dues and payable by the Company which have not been timely paid.  There are no accrued and unpaid federal, state, country, local or foreign taxes of the Company which are due, whether or not assessed or disputed.  There have been no examinations or audits of any tax returns or reports by any applicable federal, state, local or foreign governmental agency.  The Company has duly and timely filed all federal, state, county, local and foreign tax returns required to have been filed by it and there are in effect no waivers of applicable statutes of limitations with respect to taxes for any year.

 

3.18.                     Insurance.  The Company has in full force and effect fire and casualty insurance policies with extended coverage, sufficient in amount (subject to reasonable deductions) to allow it to replace any of its properties that might be damaged or destroyed.

 

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3.19.                     Confidential Information and Invention Assignment Agreements.

 

(a)                                 Each current and former employee, consultant and officer of the Company has executed an agreement with the Company regarding confidentiality and proprietary information in the form or forms delivered to the Major Investors (the “Employee/Consulting Agreements”).  Except as set forth in Section 3.19(a) of the Disclosure Schedule, no current or former Key Employee or consultant of the Company has excluded works or inventions from his or her assignment of inventions pursuant to such person’s Employee/Consulting Agreement.  The Company is not aware that any of its Key Employees or consultants is in violation thereof.

 

(b)                                 Each Key Employee has entered into non-competition and non-solicitation covenants as set forth in the Employee/Consulting Agreements.

 

3.20.                     Permits.  The Company and each of its subsidiaries has all franchises, permits, licenses and any similar authority (each a “Permit”) necessary for the conduct of its business, the lack of which could reasonably be expected to have a Material Adverse Effect.  The Company is not in default in any material respect under any of such Permits.

 

3.21.                     Corporate Documents.  The Restated Certificate and Bylaws of the Company are in the form provided to the Purchasers.  The copy of the minute books of the Company provided to the Purchasers contains minutes of all meetings of directors and stockholders and all actions by written consent without a meeting by the directors and stockholders since the date of incorporation and accurately reflects in all material respects all actions by the directors (and any committee of directors) and stockholders with respect to all transactions referred to in such minutes.

 

3.22.                     Real Property Holding Corporation.  The Company is not now and has never been a “United States real property holding corporation” as defined in the Code and any applicable regulations promulgated thereunder.  The Company has filed with the Internal Revenue Service all statements, if any, with its United States income tax returns which are required under such regulations.

 

3.23.                     Environmental and Safety Laws.  Except as could not reasonably be expected to have a Material Adverse Effect: (a) the Company is and has been in compliance with all Environmental Laws; (b) there has been no release or threatened release of any pollutant, contaminant or toxic or hazardous material, substance or waste, or petroleum or any fraction thereof, (each a “Hazardous Substance”) on, upon, into or from any site currently or heretofore owned, leased or otherwise used by the Company; (c) there have been no Hazardous Substances generated by the Company that have been disposed of or come to rest at any site that has been included in any published U.S. federal, state or local “superfund” site list or any other similar list of hazardous or toxic waste sites published by any governmental authority in the United States; and (d) there are no underground storage tanks located on, no polychlorinated biphenyls (“PCBs”) or PCB-containing equipment used or stored on, and no hazardous waste as defined by the Resource Conservation and Recovery Act, as amended, stored on, any site owned or operated by the Company, except for the storage of hazardous waste in compliance with Environmental Laws.  The Company has made available to the Purchasers true and complete copies of all

 

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material environmental records, reports, notifications, certificates of need, permits, pending permit applications, correspondence, engineering studies, and environmental studies or assessments.

 

For purposes of this Section 3.23, “Environmental Laws” means any law, regulation, or other applicable requirement relating to (a) releases or threatened release of Hazardous Substance; (b) pollution or protection of employee health or safety, public health or the environment; or (c) the manufacture, handling, transport, use, treatment, storage, or disposal of Hazardous Substances.

 

3.24.                     No General Solicitation.  Neither the Company, nor any of is officers, directors, employees, agents, managers, stockholders or other equity holders has either directly or indirectly, including through a broker or finder (a) engaged in any general solicitation, or (b) published any advertisement in connection with the offer and sale of the Shares.

 

3.25.                     Disclosure.  The Company has made available to the Purchasers all the information reasonably available to the Company that the Purchasers have requested for deciding whether to acquire the Shares.  No representation or warranty of the Company contained in this Agreement, as qualified by the Disclosure Schedule, and no certificate furnished or to be furnished to Purchasers at the Closings contains or will contain any untrue statement of a material fact or omits or will omit to state a material fact necessary in order to make the statements contained herein or therein not misleading in light of the circumstances under which they were made.

 

3.26.                     Regulatory Compliance.

 

(a)                                 The Company, and to the Company’s knowledge, the Company’s agents, are in material compliance with all statutes, rules and regulations of the Federal Food and Drug Administration (the “FDA”) with respect to the evaluation, testing, manufacturing, and distribution of each of the Company s products, in whatever stage of development, to the extent that the same are applicable to the Company’s business as it is currently conducted and proposed to be conducted, including, but not limited to, those relating to investigational use, current “Good Manufacturing Practices,” current “Good Laboratory Practice,” current “Good Clinical Practice,” labeling, record keeping, reporting of adverse events and filing of reports.

 

(b)                                 Section 3.26(b) of the Disclosure Schedule sets forth a true, complete and accurate list of the material products that are currently being developed, tested, manufactured, distributed or licensed in or out by the Company as of the date of this Agreement.

 

(c)                                  Section 3.26(c) of the Disclosure Schedule sets forth a true, complete and accurate list of each of the Company s pending and approved Investigational New Drug Applications (“INDs”) and similar state and foreign regulatory filings as of the date of this Agreement.  As to each drug for which such an IND application has become effective, and to the extent applicable, the Company is in substantial compliance with 21 U.S.C. § 355 or 21 C.F.R. Parts 312 and 600, respectively, and similar state and foreign laws and regulations and all terms and conditions of such applications.

 

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(d)                                 Neither the Company nor, to the Company’s knowledge, any of its officers, employees or agents has made an untrue statement of a material fact or fraudulent statement to the FDA or other governmental entity, failed to disclose a material fact required to be disclosed to the FDA or other governmental entity, or committed an act, made a statement, or failed to make a statement that, at the time such disclosure was made, could reasonably be expected to provide a basis for the FDA to invoke its policy respecting “Fraud, Untrue Statements of Material Facts, Bribery, and Illegal Gratuities”, set forth in 56 Fed. Reg. 46191 (September 10, 1991) or any similar policy.  Neither the Company nor any of its officers, employees or agents has been convicted of any crime or engaged in any conduct for which debarment is mandated by 21 U.S.C. § 335a(a) or any similar state or foreign law or regulation or for which debarment is authorized by 21 U.S.C. § 335a(b) or any similar state or foreign law or regulation.

 

3.27.                     Studies.

 

(a)                                 The clinical, pre-clinical, safety and other studies and tests conducted by or on behalf of or sponsored by the Company were and, if still pending, are being conducted in material compliance with standard medical and scientific research procedures.  The Company has operated within, and currently is in material compliance with, all applicable rules, regulations and policies of the FDA for such studies.  The Company has not received any notices or other correspondence from the FDA or any other governmental entity requiring the termination, suspension or modification of any clinical, pre-clinical, safety or other studies or tests.

 

4.                                      Representations and Warranties of the Purchasers.  Each Purchaser hereby represents and warrants to the Company, severally and not jointly, that:

 

4.1.                            Authorization.  The Purchaser has full power and authority to enter into the Transaction Agreements.  The Transaction Agreements to which such Purchaser is a party, when executed and delivered by the Purchaser, will constitute valid and legally binding obligations of the Purchaser, enforceable in accordance with their terms, except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance, and any other laws of general application affecting enforcement of creditors’ rights generally, and as limited by laws relating to the availability of specific performance, injunctive relief, or other equitable remedies, or (b) to the extent the indemnification provisions contained in the Investors’ Rights Agreement may be limited by applicable federal or state securities laws.

 

4.2.                            Purchase Entirely for Own Account.  This Agreement is made with the Purchaser in reliance upon the Purchaser’s representation to the Company, which by the Purchaser’s execution of this Agreement, the Purchaser hereby confirms, that the Shares to be acquired by the Purchaser will be acquired for investment for the Purchaser’s own account, not as a nominee or agent, and not with a view to the resale or distribution of any part thereof, and that the Purchaser has no present intention of selling, granting any participation in, or otherwise distributing the same.  By executing this Agreement, the Purchaser further represents that the Purchaser does not presently have any contract, undertaking, agreement or arrangement with any Person to sell, transfer or grant participations to such Person or to any third Person, with respect

 

35

 

to any of the Shares.  The Purchaser has not been formed for the specific purpose of acquiring the Shares.

 

4.3.                            Disclosure of Information.  The Purchaser has had an opportunity to: (a) discuss with the Company’s management the Company’s business, management and financial affairs, the terms and conditions of the offering of the Shares; and (b) review the Company’s facilities.  The foregoing, however, does not limit or modify the representations and warranties of the Company in Section 3 of this Agreement or the right of the Purchasers to rely thereon.

 

4.4.                            Restricted Securities.  The Purchaser understands that the Shares have not been, and will not be, registered under the Securities Act, by reason of a specific exemption from the registration provisions of the Securities Act which depends upon, among other things, the bona fide nature of the investment intent and the accuracy of the Purchaser’s representations as expressed herein.  The Purchaser understands that the Shares are “restricted securities” under applicable U.S. federal and state securities laws and that, pursuant to these laws, the Purchaser must hold the Shares indefinitely unless they are registered with the Securities and Exchange Commission and qualified by state authorities, or an exemption from such registration and qualification requirements is available.  The Purchaser acknowledges that the Company has no obligation to register or qualify the Shares for resale except if and to the extent set forth in the Investors’ Rights Agreement.  The Purchaser further acknowledges that if an exemption from registration or qualification is available, it may be conditioned on various requirements including, but not limited to, the time and manner of sale, the holding period for the Shares and on requirements relating to the Company which are outside of the Purchaser’s control, and which the Company is under no obligation and may not be able to satisfy.

 

4.5.                            No Public Market.  The Purchaser understands that no public market now exists for the Shares, and that the Company has made no assurances that a public market will ever exist for the Shares.

 

4.6.                            Legends.  The Purchaser understands that the Shares may bear one or all of the following legends:

 

(a)                                 “THE SHARES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF.  NO SUCH TRANSFER MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933.”

 

(b)                                 Any legend set forth in, or required by, any of the other Transaction Agreements.

 

(c)                                  Any legend required by the securities laws of any state to the extent such laws are applicable.

 

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4.7.                            Accredited Investor.  The Purchaser is an accredited investor as defined in Rule 501(a) of Regulation D promulgated under the Securities Act.

 

4.8.                            Foreign Investors.  If the Purchaser is not a United States person (as defined by Section 7701(a)(30) of the Code), such Purchaser hereby represents that it has satisfied itself as to the full observance of the laws of its jurisdiction in connection with any invitation to subscribe for the Shares or any use of this Agreement, including (i) the legal requirements within its jurisdiction for the purchase of the Shares, (ii) any foreign exchange restrictions applicable to such purchase, (iii) any governmental or other consents that may need to be obtained, and (iv) the income tax and other tax consequences, if any, that may be relevant to the purchase, holding, redemption, sale, or transfer of the Shares.  Such Purchaser’s subscription and payment for and/or continued beneficial ownership of the Shares will not violate any applicable securities or other laws of the Purchaser’s jurisdiction.

 

4.9.                            No General Solicitation. Neither the Purchaser, nor any of its officers, directors, employees, agents, stockholders or partners has either directly or indirectly, including through a broker or finder (a) engaged in any general solicitation, or (b) published any advertisement, in connection with the offer and sale of the Shares.

 

4.10.                     Exculpation Among Purchasers.  Each Purchaser acknowledges that it is not relying upon any Person, other than the Company and its officers and directors, in making its investment or decision to invest in the Company.  Each Purchaser agrees that no Purchaser nor the respective controlling Persons, officers, directors, partners, agents, or employees of any Purchaser shall be liable to any other Purchaser for any action heretofore or hereafter taken or omitted to be taken by any of them in connection with the purchase of the Shares.

 

4.11.                     Residence.  If the Purchaser is an individual, then the Purchaser resides in the state or province identified in the address of the Purchaser set forth on Exhibit A; if the Purchaser is a partnership, corporation, limited liability company or other entity, then the office or offices of the Purchaser in which its principal place of business is identified is the address or addresses of the Purchaser set forth on Exhibit A.

 

5.                                      Closing Conditions

 

5.1.                            Conditions to the Purchasers’ Obligations at Initial Tranche Closing.  The obligations of each Purchaser to purchase Shares at the Initial Tranche Closing are subject to the fulfillment, on or before the Initial Tranche Closing, of each of the following conditions, unless otherwise waived:

 

(a)                                 Representations and Warranties.  The representations and warranties of the Company contained in Section 3, as modified by the Updated Disclosure Schedule delivered at the Initial Tranche Closing, shall be true and correct as of the Initial Tranche Closing except for those representations and warranties which address matters only as of a particular date (which representations shall have been true and correct as of such particular date).

 

(b)                                 Performance.  The Company shall have performed and complied with all covenants, agreements, obligations and conditions contained in this Agreement that are

 

37

 

required to be performed or complied with by the Company on or before the Initial Tranche Closing.

 

(c)                                  Compliance Certificate.  The President of the Company shall have delivered to the Purchasers at the Initial Tranche Closing a certificate certifying that the conditions specified in Sections 5.1(a) and 5.1(b) have been fulfilled.

 

(d)                                 Qualifications.  All authorizations, approvals or permits, if any, of any governmental authority or regulatory body of the United States or of any state that are required in connection with the lawful issuance and sale of the Shares pursuant to this Agreement at the Initial Tranche Closing shall be obtained and effective as of the Initial Tranche Closing.

 

(e)                                  Opinion of Company Counsel.  The Purchasers shall have received from Bingham McCutchen LLP, counsel for the Company, an opinion, dated as of the Initial Tranche Closing, in substantially the form of Exhibit H-1 attached to this Agreement.

 

(f)                                   Board of Directors.  As of the Initial Tranche Closing, the Company’s Board of Directors shall be comprised of Todd Foley, Hubert Birner, John G. Freund, Brendan O’Leary, Timothy Noyes, F. Nicholas Franano, Greg Phelps, Tim Haines and Dmitry Kobyzev.  In addition, as of the Initial Tranche Closing, the Company’s Board of Directors shall have an Audit Committee comprised of Brendan O’Leary, Hubert Birner, Todd Foley and Dmitry Kobyzev, a Compensation Committee comprised of Brendan O’Leary, Hubert Birner, Greg Phelps and Tim Haines, a Nominating and Governance Committee comprised of Hubert Birner, Todd Foley, Tim Haines and Dmitry Kobyzev and no other committees.

 

(g)                                  Investors’ Rights Agreement.  The Company, each other Purchaser and any other stockholder of the Company that is required to sign the Investors’ Rights Agreement in order for it to be an effective and legally binding agreement on all parties thereto, shall have executed and delivered the Investors’ Rights Agreement.

 

(h)                                 Right of First Refusal and Co-Sale Agreement.  The Company, each other Purchaser that is a Major Investor, and any other stockholder of the Company that is required to sign the Right of First Refusal and Co-Sale Agreement in order for it to be an effective and legally binding agreement on all parties thereto, shall have executed and delivered the Right of First Refusal and Co-Sale Agreement.

 

(i)                                     Voting Agreement.  The Company, each other Purchaser, and any other stockholder of the Company that is required to sign the Voting Agreement in order for it to be an effective and legally binding agreement on all parties thereto, shall have executed and delivered the Voting Agreement.

 

(j)                                    Restated Certificate.  The Company shall have filed the Restated Certificate with the Secretary of State of Delaware on or prior to the Initial Tranche Closing.

 

(k)                                 Secretary’s Certificate. The Secretary of the Company shall have delivered to the Purchasers at the Initial Tranche Closing a certificate certifying (i) the Bylaws of the Company, (ii) resolutions of the Board of Directors of the Company approving the

 

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Transaction Agreements and the transactions contemplated under the Transaction Agreements, and (iii) resolutions of the stockholders of the Company approving the Restated Certificate.

 

(l)                                     Proceedings and Documents.  All corporate and other proceedings in connection with the transactions contemplated at the Initial Tranche Closing and all documents incident thereto shall be reasonably satisfactory in form and substance to each Purchaser, and each Purchaser (or its counsel) shall have received all such counterpart original and certified or other copies of such documents as reasonably requested.  Such documents may include good standing certificates.

 

(m)                             Management Rights.  A Management Rights Letter shall have been executed by the Company and delivered to each Major Investor that makes a request for such Management Rights Letter.

 

(n)                                 Delivery of Operating Budgets.  The Company shall have delivered to the Major Investors proposed operating budgets for the years 2014, 2015 and 2016 reasonably acceptable to the Major Investors (collectively, the “Proposed Budgets”).

 

(o)                                 Indemnification Agreements.  The Company shall have executed and delivered an Indemnification Agreement with each of Tim Haines and Dmitry Kobyzev in substantially the form of Exhibit J attached to this Agreement.

 

(p)                                 Minimum Aggregate Purchase Price at Initial Tranche Closing.  The aggregate purchase price of the Shares issued and sold at the Initial Tranche Closing shall be at least $22,500,000.

 

(q)                                 Increase in Shares Reserved under Stock Plan. The Stock Plan shall have been amended to reserve 18,222,157 shares of Common Stock for issuance to officers, directors, employees and consultants of the Company.

 

(r)                                    No Material Adverse Effect.  There shall not have been any event or series of events that has caused a Material Adverse Effect.

 

5.2.                            Conditions to the Purchasers’ Obligations at Second Tranche Closing.  The obligations of each Purchaser to purchase Shares at the Second Tranche Closing, if any, are subject to the fulfillment, on or before the Second Tranche Closing, of each of the following conditions, unless otherwise waived:

 

(a)                                 Representations and Warranties.  The representations and warranties of the Company contained in Section 3, as modified by the Updated Disclosure Schedule delivered at the Second Tranche Closing, shall be true and correct as of the Second Tranche Closing except for those representations and warranties which address matters only as of a particular date (which representations shall have been true and correct as of such particular date).

 

(b)                                 Performance.  The Company shall have performed and complied with all covenants, agreements, obligations and conditions contained in this Agreement that are

 

39

 

required to be performed or complied with by the Company on or before the Second Tranche Closing.

 

(c)                                  Compliance Certificate.  The President of the Company shall have delivered to the Purchasers at the Second Tranche Closing a certificate certifying that the conditions specified in Sections 5.2(a) and 5.2(b) have been fulfilled.

 

(d)                                 Opinion of Company Counsel.  The Purchasers shall have received from Bingham McCutchen LLP, counsel for the Company, an opinion, dated as of the Second Tranche Closing, in substantially the form of Exhibit H-2 attached to this Agreement.

 

(e)                                  No Material Adverse Effect.  There shall not have been any event or series of events that has caused a Material Adverse Effect.

 

(f)                                   Minimum Aggregate Purchase Price at Second Tranche Closing.  The aggregate purchase price of the Shares issued and sold at the Second Tranche Closing shall be at least $4,500,000.

 

5.3.                            Conditions to the Purchasers’ Obligations at Third Tranche Closing.  The obligations of each Purchaser to purchase Shares at the Third Tranche Closing, if any, are subject to the fulfillment, on or before the Third Tranche Closing, of each of the following conditions, unless otherwise waived:

 

(a)                                 Representations and Warranties.  The representations and warranties of the Company contained in Section 3, as modified by the Updated Disclosure Schedule delivered at the Third Tranche Closing, shall be true and correct as of the Third Tranche Closing except for those representations and warranties which address matters only as of a particular date (which representations shall have been true and correct as of such particular date).

 

(b)                                 Performance.  The Company shall have performed and complied with all covenants, agreements, obligations and conditions contained in this Agreement that are required to be performed or complied with by the Company on or before the Third Tranche Closing.

 

(c)                                  Compliance Certificate.  The President of the Company shall have delivered to the Purchasers at the Third Tranche Closing a certificate certifying that the conditions specified in Sections 5.3(a) and 5.3(b) have been fulfilled.

 

(d)                                 Opinion of Company Counsel.  The Purchasers shall have received from Bingham McCutchen LLP, counsel for the Company, an opinion, dated as of the Third Tranche Closing, in substantially the form of Exhibit H-3 attached to this Agreement.

 

(e)                                  No Material Adverse Effect.  There shall not have been any event or series of events that has caused a Material Adverse Effect.

 

40

 

(f)                                   Minimum Aggregate Purchase Price at Third Tranche Closing.  The aggregate purchase price of the Shares issued and sold at the Third Tranche Closing shall be at least $13,500,000.

 

5.4.                            Conditions to the Company’s Obligations at Initial Tranche Closing.  The obligations of the Company to sell Shares to the Purchasers at the Initial Tranche Closing are subject to the fulfillment, on or before the Initial Tranche Closing, of each of the following conditions, unless otherwise waived:

 

(a)                                 Representations and Warranties.  The representations and warranties of each Purchaser contained in Section 4 shall be true and correct as of the Initial Tranche Closing.

 

(b)                                 Performance.  The Purchasers shall have performed and complied with all covenants, agreements, obligations and conditions contained in this Agreement that are required to be performed or complied with by them on or before the Initial Tranche Closing.

 

(c)                                  Qualifications.  All authorizations, approvals or permits, if any, of any governmental authority or regulatory body of the United States or of any state that are required in connection with the lawful issuance and sale of the Shares pursuant to this Agreement at the Initial Tranche Closing shall be obtained and effective as of the Initial Tranche Closing.

 

(d)                                 Investors’ Rights Agreement.  Each Purchaser, as well as any other stockholder of the Company that is required to sign the Investors’ Rights Agreement in order for it to be an effective and legally binding agreement on all parties thereto, shall have executed and delivered the Investors’ Rights Agreement.

 

(e)                                  Right of First Refusal and Co-Sale Agreement.  Each Purchaser who is a Major Investor, as well as any other stockholder of the Company that is required to sign the Right of First Refusal and Co-Sale Agreement in order for it to be an effective and legally binding agreement on all parties thereto, shall have executed and delivered the Right of First Refusal and Co-Sale Agreement.

 

(f)                                   Voting Agreement.  Each Purchaser, as well as any other stockholder of the Company that is required to sign the Voting Agreement in order for it to be an effective and legally binding agreement on all parties thereto, shall have executed and delivered the Voting Agreement.

 

(g)                                  Increase in Shares Reserved under Stock Plan. The Stock Plan shall have been amended to reserve 18,222,157 shares of Common Stock for issuance to officers, directors, employees and consultants of the Company.

 

5.5.                            Conditions to the Company’s Obligations at Second Tranche Closing.  The obligations of the Company to sell Shares at the Second Tranche Closing are subject to the fulfillment, on or before the Second Tranche Closing, of each of the following conditions, unless otherwise waived:

 

41

 

(a)                                 Representations and Warranties.  The representations and warranties of each Purchaser contained in Section 4 shall be true and correct as of the Second Tranche Closing.

 

(b)                                 Performance.  The Purchasers shall have performed and complied with all covenants, agreements, obligations and conditions contained in this Agreement that are required to be performed or complied with by them on or before the Second Tranche Closing.

 

(c)                                  Qualifications.  All authorizations, approvals or permits, if any, of any governmental authority or regulatory body of the United States or of any state that are required in connection with the lawful issuance and sale of the Shares pursuant to this Agreement at the Second Tranche Closing shall be obtained and effective as of the Second Tranche Closing.

 

5.6.                            Conditions to the Company’s Obligations at Third Tranche Closing.  The obligations of the Company to sell Shares at the Third Tranche Closing are subject to the fulfillment, on or before the Third Tranche Closing, of each of the following conditions, unless otherwise waived:

 

(a)                                 Representations and Warranties.  The representations and warranties of each Purchaser contained in Section 4 shall be true and correct as of the Third Tranche Closing.

 

(b)                                 Performance.  The Purchasers shall have performed and complied with all covenants, agreements, obligations and conditions contained in this Agreement that are required to be performed or complied with by them on or before the Third Tranche Closing.

 

(c)                                  Qualifications.  All authorizations, approvals or permits, if any, of any governmental authority or regulatory body of the United States or of any state that are required in connection with the lawful issuance and sale of the Shares pursuant to this Agreement at the Third Tranche Closing shall be obtained and effective as of the Third Tranche Closing.

 

6.                                      Miscellaneous.

 

6.1.                            Survival of Warranties.  Unless otherwise set forth in this Agreement, the representations and warranties of the Company and the Purchasers contained in or made pursuant to this Agreement shall survive the execution and delivery of this Agreement and the Closing and shall in no way be affected by any investigation or knowledge of the subject matter thereof made by or on behalf of the Purchasers or the Company.

 

6.2.                            Successors and Assigns.  The terms and conditions of this Agreement shall inure to the benefit of and be binding upon the respective successors and assigns of the parties.  Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective successors and assigns any rights, remedies, obligations, or liabilities under or by reason of this Agreement, except as expressly provided in this Agreement.

 

42

 

6.3.                            Governing Law.  This Agreement shall be governed by and construed in accordance with the General Corporation Law of the State of Delaware as to matters within the scope thereof, and as to all other matters shall be governed by and construed in accordance with the internal laws of the Commonwealth of Massachusetts, without regard to its principles of conflicts of laws.

 

6.4.                            Counterparts; Facsimile.  This Agreement may be executed and delivered by facsimile signature and in two or more counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.

 

6.5.                            Titles and Subtitles.  The titles and subtitles used in this Agreement are used for convenience only and are not to be considered in construing or interpreting this Agreement.

 

6.6.                            Notices.  All notices and other communications given or made pursuant to this Agreement shall be in writing and shall be deemed effectively given:  (a) upon personal delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the recipient, and if not so confirmed, then on the next business day, (c) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one (1) day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt.  All communications shall be sent to the respective parties at their address as set forth on the signature pages or to such e-mail address, facsimile number or address as subsequently modified by written notice given in accordance with this Section 6.6.  If notice is given to the Company, a copy shall also be sent to:

 

Julio E. Vega

Bingham McCutchen LLP

One Federal Street

Boston, MA 02110

e-mail:  julio.vega@bingham.com

fax:  617-951-8736

 

and if notice is given to the Purchasers, a copy shall also be given to:

 

Lowell A. Segal

Ropes & Gray LLP

1900 University Avenue, 6th Floor
 East Palo Alto, CA 94303

e-mail:  Lowell.Segal@ropesgray.com

fax:  650-566-4244

 

6.7.                            No Finder’s Fees.  Each party represents that it neither is nor will be obligated for any finder’s fee or commission in connection with this transaction.  Each Purchaser agrees to indemnify and to hold harmless the Company from any liability for any commission or compensation in the nature of a finder’s or broker’s fee arising out of this transaction (and the costs and expenses of defending against such liability or asserted liability) for which each

 

43

 

Purchaser or any of its officers, employees, or representatives is responsible.  The Company agrees to indemnify and hold harmless each Purchaser from any liability for any commission or compensation in the nature of a finder’s or broker’s fee arising out of this transaction (and the costs and expenses of defending against such liability or asserted liability) for which the Company or any of its officers, employees or representatives is responsible.

 

6.8.                            Fees and Expenses.  At the Closing, the Company shall pay or reimburse Abingworth and Pharmstandard, collectively, for their reasonable expenses in connection with their due diligence investigation with respect to financial and tax matters performed by The Brenner Group, Inc., in an amount not to exceed $11,000, and the reasonable fees and expenses of Ropes & Gray LLP, special transaction legal counsel for Abingworth and Pharmstandard, in an amount not to exceed $79,000 in the aggregate, in connection with due diligence and the review and negotiation of the Transaction Agreements and the consummation of the transactions contemplated under the Transaction Agreements.

 

6.9.                            Amendments and Waivers.  Any term of this Agreement may be amended, terminated or waived only with the written consent of the Company and the holders of sixty five percent (65%) of the then-outstanding Shares, except that any amendment, termination or waiver of any provision in Section 1.1(d)(ii) requiring approval or waiver by Purchasers that hold at least seventy-five percent (75%) of the Tranche Shares then issued and outstanding  must also be approved by Purchasers that hold at least seventy-five percent (75%) of the Tranche Shares then issued and outstanding; provided, however, that no amendment to this Agreement that increases or adds to a Purchaser’s obligations or commitments under this Agreement, shall be effective against such Purchaser without the prior written consent of such Purchaser; further provided that this Agreement may not be amended, modified or terminated and the observance of any term hereof may not be waived with respect to any Purchaser without such Purchaser’s consent unless such amendment, modification, termination or waiver applies to all Purchasers in the same fashion.  Any amendment or waiver effected in accordance with this Section 6.9 shall be binding upon the Purchasers and each transferee of the Shares, and each future holder of any or all such securities, and the Company.

 

6.10.                     Severability.  The invalidity or unenforceability of any provision hereof shall in no way affect the validity or enforceability of any other provision.

 

6.11.                     Delays or Omissions.  No delay or omission to exercise any right, power or remedy accruing to any party under this Agreement, upon any breach or default of any other party under this Agreement, shall impair any such right, power or remedy of such non-breaching or non-defaulting party nor shall it be construed to be a waiver of any such breach or default, or an acquiescence therein, or of or in any similar breach or default thereafter occurring; nor shall any waiver of any single breach or default be deemed a waiver of any other breach or default theretofore or thereafter occurring.  Any waiver, permit, consent or approval of any kind or character on the part of any party of any breach or default under this Agreement, or any waiver on the part of any party of any provisions or conditions of this Agreement, must be in writing and shall be effective only to the extent specifically set forth in such writing.  All remedies, either under this Agreement or by law or otherwise afforded to any party, shall be cumulative and not alternative.

 

44

 

6.12.                     Entire Agreement.  This Agreement (including the Exhibits hereto), the Restated Certificate and the other Transaction Agreements constitute the full and entire understanding and agreement between the parties with respect to the subject matter hereof, and any other written or oral agreements relating to the subject matter hereof existing between the parties are expressly cancelled as of the Initial Tranche Closing.

 

6.13.                     Dispute Resolution.  The parties (a) hereby irrevocably and unconditionally submit to the jurisdiction of the state courts of Massachusetts and to the jurisdiction of the United States District Court for the District of Massachusetts for the purpose of any suit, action or other proceeding arising out of or based upon this Agreement, (b) agree not to commence any suit, action or other proceeding arising out of or based upon this Agreement except in the state courts of Massachusetts or the United States District Court for the District of Massachusetts, and (c) hereby waive, and agree not to assert, by way of motion, as a defense, or otherwise, in any such suit, action or proceeding, any claim that it is not subject personally to the jurisdiction of the above-named courts, that its property is exempt or immune from attachment or execution, that the suit, action or proceeding is brought in an inconvenient forum, that the venue of the suit, action or proceeding is improper or that this Agreement or the subject matter hereof may not be enforced in or by such court.  Each party will bear its own costs in respect of any disputes arising under this Agreement.  Each of the parties to this Agreement consents to personal jurisdiction for any equitable action sought in the U.S. District Court for the District of Massachusetts or any court of the Commonwealth of Massachusetts having subject matter jurisdiction.

 

6.14.                     No Commitment for Additional Financing.  The Company acknowledges and agrees that no Purchaser has made any representation, undertaking, commitment or agreement to provide or assist the Company in obtaining any financing, investment or other assistance, other than the purchase of the Shares as set forth herein, subject to the conditions set forth herein.  In addition, the Company acknowledges and agrees that, subject to the terms and conditions set forth herein, (x) no statements, whether written or oral, made by any Purchaser or its representatives on or after the date of this Agreement shall create an obligation, commitment or agreement to provide or assist the Company in obtaining any financing or investment, (y) the Company shall not rely on any such statement by any Purchaser or its representatives and (z) an obligation, commitment or agreement to provide or assist the Company in obtaining any financing or investment may only be created by a written agreement, signed by such Purchaser and the Company, setting forth the terms and conditions of such financing or investment and stating that the parties intend for such writing to be a binding obligation or agreement.  Subject to the terms and conditions set forth herein, each Purchaser shall have the right, in it sole and absolute discretion, to refuse or decline to participate in any other financing of or investment in the Company, and shall have no obligation to assist or cooperate with the Company in obtaining any financing, investment or other assistance.

 

6.15.                     Covenant Relating to Registration.  The Company shall use commercially reasonable efforts to file a registration statement on Form S-1 with the Securities and Exchange Commission with respect to a firm commitment underwritten initial public offering of the Company’s Common Stock and to cause such registration statement to become effective within eighteen (18) months after the Initial Tranche Closing.

 

45

 

[Remainder of Page Intentionally Left Blank]

 

46

 

IN WITNESS WHEREOF, the parties have executed this Series D Preferred Stock Purchase Agreement as of the date first written above.

 

	
 
    	
PROTEON   THERAPEUTICS, INC.
    
	
 
    	
 
    
	
 
    	
By:
    	
/s/   Timothy Noyes
    
	
 
    	
 
    	
Timothy   Noyes
    
	
 
    	
 
    	
President   and Chief Executive Officer
    
	
 
    	
 
    
	
 
    	
 
    
	
 
    	
Address:
    
	
 
    	
 
    	
200   West Street
    
	
 
    	
 
    	
Waltham,   MA 02451
    
	
 
    	
 
    
	
 
    	
Email: 
    
	
 
    	
Fax:   
    

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK  PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Abingworth   Bioventures VI, LP
    
	
 
    	
 
    
	
 
    	
By:
    	
 
    
	
 
    	
By:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Partner
    
	
 
    	
 
    
	
 
    	
Address:
    	
38   Jermyn Street
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
London   SWIY 6DN
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
United   Kingdom
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
				

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Pharmstandard   International S.A.
    
	
 
    	
 
    
	
 
    	
By:
    	
/s/   Eriks Martinovsky
    	
/s/   Gerard Birchen
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Director
    	
Director
    
	
 
    	
 
    
	
 
    	
Address:
    	
65   Boulevard Grande Duchesse Charlotte
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
L-1331   Luxembourg
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Grand-Duchy   of Luxembourg
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Deerfield   Special Situations International Master Fund, L.P.
    
	
 
    	
 
    
	
 
    	
By:
    	
Deerfield   Mgmt, L.P.

General   Partner
    
	
 
    	
 
    	
By:
    	
J.E.   Flynn Capital, LLC

General   Partner
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    	
By:
    	
/s/   David J. Clark
    
	
 
    	
 
    	
 
    	
Name:
    	
David   J. Clark
    
	
 
    	
 
    	
 
    	
Title:
    	
Authorized   Signatory
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
780   Third Avenue, 37th Floor
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
New   York, NY 10017
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
						

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Deerfield   Special Situations Fund, L.P.
    
	
 
    	
 
    
	
 
    	
By:
    	
Deerfield   Mgmt, L.P.

General   Partner
    
	
 
    	
 
    	
By:
    	
J.E.   Flynn Capital, LLC

General   Partner
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    	
By:
    	
/s/   David J. Clark
    
	
 
    	
 
    	
 
    	
Name:
    	
David   J. Clark
    
	
 
    	
 
    	
 
    	
Title:
    	
Authorized   Signatory
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
780   Third Avenue, 37th Floor
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
New   York, NY 10017
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
						

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Deerfield   Private Design Fund III, L.P.
    
	
 
    	
 
    
	
 
    	
By:
    	
Deerfield   Mgmt III, L.P.

General   Partner
    
	
 
    	
 
    	
By:
    	
J.E.   Flynn Capital III, LLC

General   Partner
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    	
By:
    	
/s/   David J. Clark
    
	
 
    	
 
    	
 
    	
Name:
    	
David   J. Clark
    
	
 
    	
 
    	
 
    	
Title:
    	
Authorized   Signatory
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
780   Third Avenue, 37th Floor
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
New   York, NY 10017
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
						

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
TVM   Life Science Ventures VI GmbH & Co. KG
    
	
 
    	
 
    
	
 
    	
/s/   Josef Moosholzer
    	
/s/   Stefan Fischer
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
By:
    	
Josef   Moosholzer (and) Stefan Fischer
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Authorized   Officers
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
Ottostrasse   4, 80333 Munich
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Germany
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
						

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
TVM   Life Science Ventures VI LP
    
	
 
    	
By:
    	
its   General Partner TVM Life Science Ventures VI (Cayman) Ltd.
    
	
 
    	
 
    
	
 
    	
/s/   Josef Moosholzer
    	
/s/   Stefan Fischer
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
By:
    	
Josef   Moosholzer (and) Stefan Fischer
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Authorized   Officers
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
75,   Arlington St. Suite 500,
    
	
 
    	
 
    	
Boston,   MA 02116, U.S.A.
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
						

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Skyline   Venture Partners Qualified Purchaser Fund IV, LP
    
	
 
    	
By:
    	
Skyline   Venture Management IV, LLC, its General Partner
    
	
 
    	
 
    
	
 
    	
By:
    	
/s/   John G. Freund
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
John   G. Freund, Managing Director
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
525   University Ave., Suite 610
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Palo   Alto, CA 94301
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Prism   Venture Partners V, LP
    
	
 
    	
By:
    	
Prism   Investment Partners V, L.P.
   its General Partner
    
	
 
    	
 
    
	
 
    	
By:
    	
Prism   Venture Partners V, L.L.C.
   its General Partner
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
By:
    	
/s/   Brendan O’Leary
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Manging   Director
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
75   Second Avenue, Suite 210
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Needham,   MA 02494
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Prism   Venture Partners V-A, LP
    
	
 
    	
By:
    	
Prism   Investment Partners V, L.P.
   its General Partner
    
	
 
    	
 
    
	
 
    	
By:
    	
Prism   Venture Partners V, L.L.C.
   its General Partner
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
By:
    	
/s/   Brendan O’Leary
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Managing   Director
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
75   Second Avenue, Suite 210
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Needham,   MA 02494
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Intersouth   Partners VI, L.P.
    
	
 
    	
By:
    	
Intersouth   Associates VI, LLC
   its General Partners
    
	
 
    	
 
    
	
 
    	
By:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Partner
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
102   City Hall Plaza, Suite 200
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Durham,   NC 27701
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
MPM   Bio IV NVS Strategic Fund, L.P.
    
	
 
    	
By:
    	
MPM   Bioventures IV GP LLC
   its General Partner
    
	
 
    	
 
    
	
 
    	
By:
    	
MPM   Bioventures IV LLC,
   its General Partner
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
By:
    	
/s/   Toddy Foley
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Member
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
200   Clarendon Street, 54th Floor
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Boston,   MA 02116
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Vectis   Healthcare & Life Sciences Fund II, L.P.
    
	
 
    	
By:
    	
Vectis   II GP, LP
    
	
 
    	
Its:
    	
General   Partner
    
	
 
    	
By:
    	
Vectis   II GP, LLC
    
	
 
    	
Its:
    	
General   Partner
    
	
 
    	
 
    
	
 
    	
By:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Authorized   Person
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
84   State Street, Suite 320
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Boston,   MA 02109
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Devon   Park Bioventures, L.P.
    
	
 
    	
By:
    	
Devon   Park associates, L.P.
    
	
 
    	
 
    	
its   General Partner
    
	
 
    	
 
    
	
 
    	
By:
    	
/s/   Marc J. Ostro
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
General   Partner
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
1400   Liberty Ridge Drive
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Suite   103
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Wayne,   PA 19087
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
BVP   VII Special Opportunity Fund, L.P.
    
	
 
    	
By:
    	
Deer   VII & Co. L.P., their General Partner
    
	
 
    	
By:
    	
Deer   VII & Co., Ltd., its General Partner
    
	
 
    	
 
    
	
 
    	
By:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Director
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
c/o   Bessemer Venture Partners
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
1865   Palmer Avenue, Suite 104
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Larchmont,   NY 10538
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Bessemer   Venture Partners VII L.P.
    
	
 
    	
By:
    	
Deer   VII & Co. L.P., their General Partner
    
	
 
    	
By:
    	
Deer   VII & Co., Ltd., its General Partner
    
	
 
    	
 
    
	
 
    	
By:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Director
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
c/o   Bessemer Venture Partners
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
1865   Palmer Avenue, Suite 104
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Larchmont,   NY 10538
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Bessemer   Venture Partners VII Institutional L.P.
    
	
 
    	
By:
    	
Deer   VII & Co. L.P., their General Partner
    
	
 
    	
By:
    	
Deer   VII & Co., Ltd., its General Partner
    
	
 
    	
 
    
	
 
    	
By:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Director
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
c/o   Bessemer Venture Partners
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
1865   Palmer Avenue, Suite 104
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Larchmont,   NY 10538
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Rockhill   Partners, LLC
    
	
 
    	
 
    	
 
    
	
 
    	
By:
    	
/s/   James G. Clarke
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Vice   President
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Kansas   City, MO 64154
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Christena   A. Gautreaux Trust u/t/a 3-8-04
    
	
 
    	
 
    
	
 
    	
By:
    	
/s/   Christena Gautreauk
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Trustee
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
200   W. 54th Street
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Kansas   City, MO 64112
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
DeMars   Pension Consulting Services, Inc.
   Profit Sharing 401(k) Plan
    
	
 
    	
 
    
	
 
    	
By:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Trustee
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
Attn.   Jim DeMars
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
8700   Indian Creek Parkway
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Suite   185
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Overland   Park, KS 66210
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
William   P. Whitaker Trustee u/t/a 3-1-1994
    
	
 
    	
 
    
	
 
    	
By:
    	
/s/   William P. Whitaker 
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Trustee
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
9825   Overbrook Court
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Leawood,   KS 66206
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
[ILLEGIBLE]
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Patricia   A. Heary Trust
    
	
 
    	
 
    
	
 
    	
By:
    	
/s/   Patricia A. Heary 
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
5735   Ward Parkway
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Kansas   City, MO 64113
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Sudarshan   Hebbar Trust U.T.A., dated October 30, 2011
    
	
 
    	
 
    
	
 
    	
/s/   Sudarshan Hebbar
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
Sudarshan   Hebbar, Trustee
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
4342   Rockhill Rd. #3
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Kansas   City, MO 64110
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Robert   F. Eltonhead Trust
    
	
 
    	
 
    
	
 
    	
By:
    	
/s/   Robert F. Eltonhead 
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Title:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Address:
    	
57   Sugar Mill Drive
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Osprey,   FL 34229
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

PROTEON THERAPEUTICS, INC.

 

Series D Preferred Stock

Purchase Agreement

 

Purchaser Signature Page

 

By executing this page in the space provided, the undersigned hereby agrees (i) that he, she or it is a “Purchaser” as defined in the Series D Preferred Stock Purchase Agreement dated as of May 13, 2014, by and among Proteon Therapeutics, Inc. and the parties named therein (the “Purchase Agreement”), (ii) that he, she or it is a party to the Purchase Agreement for all purposes and (iii) that he, she or it is bound by all terms and conditions of the Purchase Agreement.

 

EXECUTED this 13th day of May, 2014.

 

 

	
 
    	
Darcy   A. Howe Trust
    
	
 
    	
 
    
	
 
    	
By:
    	
/s/   Darcy A. Howe 
    
	
 
    	
Name:
    	
 
    	
 
    
	
 
    	
Title:
    	
 
    
	
 
    	
Address:
    	
434   W. 56th St.
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Kanas   City, MO 64113
    
	
 
    	
 
    	
 
    
	
 
    	
Email:
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
Fax:
    	
 
    
					

 

[SIGNATURE PAGE TO THE PROTEON THERAPEUTICS, INC.

SERIES D PREFERRED STOCK PURCHASE AGREEMENT]

 

 

EXHIBITS

 

	
Exhibit A
    	
Schedule   of Purchasers
    
	
 
    	
 
    
	
Exhibit B
    	
Form of   Fifth Amended and Restated Certificate of Incorporation
    
	
 
    	
 
    
	
Exhibit C
    	
Disclosure   Schedule
    
	
 
    	
 
    
	
Exhibit D
    	
Form of   Investors’ Rights Agreement
    
	
 
    	
 
    
	
Exhibit E
    	
Form of   Management Rights Letter
    
	
 
    	
 
    
	
Exhibit F
    	
Form of   Right of First Refusal and Co-Sale Agreement
    
	
 
    	
 
    
	
Exhibit G
    	
Form of   Voting Agreement
    
	
 
    	
 
    
	
Exhibit H-1
    	
Form of   Legal Opinion of Company Counsel Delivered at Initial Tranche Closing
    
	
 
    	
 
    
	
Exhibit H-2
    	
Form of   Legal Opinion of Company Counsel Delivered at Second Tranche Closing
    
	
 
    	
 
    
	
Exhibit H-3
    	
Form of   Legal Opinion of Company Counsel Delivered at Third Tranche Closing
    
	
 
    	
 
    
	
Exhibit I
    	
Net   Issue Election Form
    
	
 
    	
 
    
	
Exhibit J
    	
Form of   Indemnification Agreement
    

 

 

EXHIBIT A

 

Schedule of Purchasers

 

	
Investor
    	
Note
   Conversion
   Shares
    	
Convertible
   Notes
   Amount
   Owed ($)
    	
Initial
   Tranche
   Shares
    	
Initial
   Tranche
   Purchase
   Price ($)
    	
Second
   Tranche
   Shares
    	
Second
   Tranche
   Purchase
   Price ($)
    	
Third
   Tranche
   Shares
    	
Third
   Tranche
   Purchase
   Price ($)
    	
Aggregate
   Shares
    	
Aggregate
   Purchase Price
   ($)
    
	
Abingworth   Bioventures VI, LP 
   38 Jermyn Street 
   London SW1Y 6DN 
   United Kingdom
    	
0
    	
0
    	
16,044,081
    	
9,444,444.55
    	
3,208,816
    	
1,888,888.80
    	
9,626,448
    	
5,666,666.38
    	
28,879,345
    	
16,999,999.73
    
	
Pharmstandard International   S.A. 
   65, Boulevard Grande Duchesse Charlotte 
   L-1331 Luxembourg 
   Grand-Duchy of Luxembourg
    	
0
    	
0
    	
8,493,925
    	
4,999,999.92
    	
1,698,785
    	
999,999.99
    	
5,096,355
    	
2,999,999.95
    	
15,289,065
    	
8,999,999.86
    
	
Deerfield   Private Design Fund III, L.P. 
   780 Third Avenue, 37th Floor 
   New York, NY 10017
    	
0
    	
0
    	
6,134,501
    	
3,611,110.83
    	
1,226,900
    	
722,222.05
    	
3,680,701
    	
2,166,666.73
    	
11,042,102
    	
6,499,999.61
    
	
Deerfield   Special Situations Fund, L.P. 
   780 Third Avenue, 37th Floor 
   New York, NY 10017
    	
0
    	
0
    	
1,311,840
    	
772,222.49
    	
262,368
    	
154,444.50
    	
787,104
    	
463,333.50
    	
2,361,312
    	
1,390,000.49
    
	
Deerfield   Special Situations International Master Fund, L.P. 
   780 Third Avenue, 37th Floor 
   New York, NY 10017
    	
0
    	
0
    	
1,047,584
    	
616,666.61
    	
209,517
    	
123,333.44
    	
628,550
    	
369,999.73
    	
1,885,651
    	
1,109,999.78
    
	
TVM   Life Science Ventures VI GmbH & Co. KG 
   c/o TVM Capital GmbH 
   TVM Life Science Management GmbH 
   Ottostrasse 4 
   (Palais am Lenbachplatz) 
   80333 Munich / Germany 
   Attn: 
    	
2,081,969
    	
918,981.32
    	
1,645,854
    	
968,841.84
    	
329,171
    	
193,768.49
    	
987,512
    	
581,304.87
    	
5,044,506
    	
2,662,896.52
    

 

 

	
Investor
    	
Note
   Conversion
   Shares
    	
Convertible
   Notes
   Amount
   Owed ($)
    	
Initial
   Tranche
   Shares
    	
Initial
   Tranche
   Purchase
   Price ($)
    	
Second
   Tranche
   Shares
    	
Second
   Tranche
   Purchase
   Price ($)
    	
Third
   Tranche
   Shares
    	
Third
   Tranche
   Purchase
   Price ($)
    	
Aggregate
   Shares
    	
Aggregate
   Purchase Price
   ($)
    
	
Stefan   Fischer
   General Partner
   Chief Financial Officer
   T +49 (89) 998 992 36
   F +49 (89) 998 992 55 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
TVM   Life Science Ventures VI, L.P.
   75 Arlington St. Suite 500
   Boston, MA 02116
   U.S.A
    
   With copies to:
   c/o TVM Capital GmbH
   TVM Life Science Management GmbH
   Ottostrasse 4
   (Palais am Lenbachplatz)
   80333 Munich / Germany
   Attn:
   Stefan Fischer
   General Partner
   Chief Financial Officer
   T +49 (89) 998 992 36
   F +49 (89) 998 992 55
    	
713,568
    	
314,968.93
    	
564,095
    	
332,057.91
    	
112,819
    	
66,411.59
    	
338,457
    	
199,234.75
    	
1,728,939
    	
912,673.18
    
	
Skyline   Venture Partners Qualified Purchaser Fund IV, L.P.
   525 University Avenue
   Suite 520
   Palo Alto, CA 94301
    	
2,196,417
    	
969,498.88
    	
1,736,330
    	
1,022,101.08
    	
347,266
    	
204,420.22
    	
1,041,798
    	
613,260.65
    	
5,321,811
    	
2,809,280.83
    
	
Prism   Venture Partners V, L.P.
   117 Kendrick Street, Suite 200
   Needham, MA 02494
    	
1,534,975
    	
677,538.22
    	
1,213,475
    	
714,319.34
    	
242,695
    	
142,863.87
    	
728,085
    	
428,591.61
    	
3,719,230
    	
1,963,313.04
    
	
Prism   Venture Partners V-A, 
    	
699,014
    	
308,545.18
    	
552,606
    	
325,294.84
    	
110,521
    	
65,058.85
    	
331,564
    	
195,177.14
    	
1,693,705
    	
894,076.01
    

 

 

	
Investor
    	
Note
   Conversion
   Shares
    	
Convertible
   Notes
   Amount
   Owed ($)
    	
Initial
   Tranche
   Shares
    	
Initial
   Tranche
   Purchase
   Price ($)
    	
Second
   Tranche
   Shares
    	
Second
   Tranche
   Purchase
   Price ($)
    	
Third
   Tranche
   Shares
    	
Third
   Tranche
   Purchase
   Price ($)
    	
Aggregate
   Shares
    	
Aggregate
   Purchase Price
   ($)
    
	
L.P.
   117 Kendrick Street, Suite 200
   Needham, MA 02494
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
Intersouth   Partners VI, L.P.
   102 City Hall Plaza, Suite 200
   Durham, NC 27701
    	
1,559,144
    	
688,206.23
    	
760,662
    	
447,768.26
    	
152,132
    	
89,553.42
    	
456,397
    	
268,660.84
    	
2,928,335
    	
1,494,188.75
    
	
MPM   Bio IV NVS Strategic Fund, LP
   200 Clarendon Street, 54th Floor
   Boston, MA 02116
    	
0
    	
0
    	
1,765,137
    	
1,039,058.49
    	
353,027
    	
207,811.47
    	
1,059,082
    	
623,434.98
    	
3,177,246
    	
1,870,304.94
    
	
Vectis   Healthcare & Life Sciences Fund II, L.P.
   c/o Brooke Private Equity Advisors
   84 State Street, Suite 320
   Boston, MA 02109
    	
50,337
    	
22,218.97
    	
141,917
    	
83,540.30
    	
28,383
    	
16,707.83
    	
85,150
    	
50,124.06
    	
305,787
    	
172,591.16
    
	
Devon   Park Bioventures, L.P.
   1400 Liberty Ridge Drive, Suite 103
   Wayne, PA 19087
    	
501,789
    	
221,489.91
    	
396,679
    	
233,507.48
    	
79,336
    	
46,701.62
    	
238,007
    	
140,104.25
    	
1,215,811
    	
641,803.26
    
	
BVP   VII Special Opportunity Fund LP
   c/o Bessemer Venture Partners
   1865 Palmer Avenue, Suite 104
   Larchmont, NY 10538
    	
270,145
    	
119,242.42
    	
213,558
    	
125,712.20
    	
42,712
    	
25,142.68
    	
128,135
    	
75,427.44
    	
654,550
    	
345,524.74
    
	
Bessemer   Venture Partners VII, L.P.
   c/o Bessemer Venture Partners
   1865 Palmer Avenue, Suite 104
   Larchmont, NY 10538
    	
160,086
    	
70,662.29
    	
126,553
    	
74,496.19
    	
25,311
    	
14,899.48
    	
75,932
    	
44,697.83
    	
387,882
    	
204,755.79
    

 

 

	
Investor
    	
Note
   Conversion
   Shares
    	
Convertible
   Notes
   Amount
   Owed ($)
    	
Initial
   Tranche
   Shares
    	
Initial
   Tranche
   Purchase
   Price ($)
    	
Second
   Tranche
   Shares
    	
Second
   Tranche
   Purchase
   Price ($)
    	
Third
   Tranche
   Shares
    	
Third
   Tranche
   Purchase
   Price ($)
    	
Aggregate
   Shares
    	
Aggregate
   Purchase Price
   ($)
    
	
Bessemer   Venture Partners VII Institutional L.P.
   c/o Bessemer Venture Partners
   1865 Palmer Avenue, Suite 104
   Larchmont, NY 10538
    	
70,038
    	
30,914.82
    	
55,367
    	
32,592.12
    	
11,073
    	
6,518.19
    	
33,220
    	
19,555.16
    	
169,698
    	
89,580.29
    
	
Rockhill   Partners, LLC
   c/o James G. Clarke
   6005 NW 101st Terrace
   Kansas City, Missouri 64154-1764
    	
120,714
    	
53,283.23
    	
95,428
    	
56,174.27
    	
19,086
    	
11,235.09
    	
57,257
    	
33,704.68
    	
292,485
    	
154,397.27
    
	
Christena   A. Gautreaux, Trustee of the Christena A. Gautreaux Revocable Trust u/t/a 3/8/04
   200 W. 54th St.
   Kansas City, Missouri 64112
    	
93,081
    	
41,086.11
    	
73,583
    	
43,315.08
    	
14,717
    	
8,663.26
    	
44,150
    	
25,989.17
    	
225,531
    	
119,053.62
    
	
DeMars Pension   Consulting Services, Inc.
   8700 Indian Creek Pkwy
   Suite 185
   Overland Park, KS 66210
    	
88,091
    	
38,883.47
    	
0
    	
0
    	
0
    	
0
    	
0
    	
0
    	
88,091
    	
38,883.47
    
	
William   P. Whitaker Trust u/t/a 3-1-1994
   9825 Overbrook Ct., Leawood, KS 66206
    	
82,013
    	
36,200.94
    	
64,835
    	
38,165.52
    	
12,967
    	
7,633.11
    	
38,901
    	
22,899.31
    	
198,716
    	
104,898.88
    
	
Robert   F. Eltonhead Trust u/t/a 12-14-95
   57 Sugar Mill Drive
   Osprey, Florida 34229
    	
65,822
    	
29,054.21
    	
0
    	
0
    	
0
    	
0
    	
0
    	
0
    	
65,822
    	
29,054.21
    
	
Patricia   A. Henry, Trustee for Patricia A. Henry Trust
   5735 Ward Parkway
   Kansas City, Missouri 64113
    	
56,998
    	
25,159.33
    	
0
    	
0
    	
0
    	
0
    	
0
    	
0
    	
56,998
    	
25,159.33
    
	
Sudarshan   Hebbar Trust U.T.A. dated 10-3-11
    	
0
    	
0.00
    	
23,594
    	
13,888.75
    	
4,719
    	
2,777.87
    	
14,157
    	
8,333.61
    	
42,470
    	
25,000.23
    

 

 

	
Investor
    	
Note
   Conversion
   Shares
    	
Convertible
   Notes
   Amount
   Owed ($)
    	
Initial
   Tranche
   Shares
    	
Initial
   Tranche
   Purchase
   Price ($)
    	
Second
   Tranche
   Shares
    	
Second
   Tranche
   Purchase
   Price ($)
    	
Third
   Tranche
   Shares
    	
Third
   Tranche
   Purchase
   Price ($)
    	
Aggregate
   Shares
    	
Aggregate
   Purchase Price
   ($)
    
	
4342 Rockhill Rd #3
   Kansas City, MO 64110
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    	
 
    
	
Darcy   A. Howe Trust
   434 W. 56th St.
   Kansas City, MO 64113
    	
0
    	
0.00
    	
8,022
    	
4,722.20
    	
1,604
    	
944.21
    	
4,813
    	
2,833.21
    	
14,439
    	
8,499.62
    
	
Total
    	
10,344,201
    	
4,565,934.46
    	
42,469,626
    	
25,000,000.27
    	
8,493,925
    	
5,000,000.03
    	
25,481,775
    	
14,999,999.85
    	
86,789,527
    	
49,565,934.61

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00235-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00235-of-00352.parquet"}]]