Document:

Amendment No. 4, dated as of January 24, 2017, to Credit Agreement

 Exhibit 10.5(e) 

AMENDMENT NO. 4 
 Dated as of
January 24, 2017 
 to 

CREDIT AGREEMENT 
 Dated as of
April 27, 2012 
 THIS AMENDMENT NO. 4 (this “Amendment”) is made as of January 24, 2017 by and among Watsco,
Inc., a Florida corporation (the “Company”), Watsco Canada, Inc., a New Brunswick corporation (the “Canadian Borrower” and, collectively with the Company, the “Borrowers”), the financial
institutions listed on the signature pages hereof and JPMorgan Chase Bank, N.A., as Administrative Agent (in such capacity, the “Administrative Agent”), under that certain Credit Agreement dated as of April 27, 2012 by and
among the Borrowers, the Canadian Subsidiary Borrowers from time to time party thereto, the Lenders, the Administrative Agent and JPMorgan Chase Bank, N.A., as Collateral Agent (as amended, restated, supplemented or otherwise modified from time to
time, the “Credit Agreement”). Capitalized terms used herein and not otherwise defined herein shall have the respective meanings given to them in the Credit Agreement. 

WHEREAS, the Borrowers have requested that the requisite Lenders and the Administrative Agent agree to certain amendments to the Credit
Agreement; 
 WHEREAS, the Borrowers, the Lenders party hereto and the Administrative Agent have so agreed on the terms and conditions set
forth herein; 
 NOW, THEREFORE, in consideration of the premises set forth above, the terms and conditions contained herein, and other good
and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Borrowers, the Lenders party hereto and the Administrative Agent hereby agree to enter into this Amendment. 

1. Amendments to the Credit Agreement. Effective as of the date of satisfaction of the conditions precedent set forth in
Section 2 below, the parties hereto agree that the Credit Agreement is hereby amended as follows: 
 (a)
Section 1.01 of the Credit Agreement is hereby amended to insert the following definition in the appropriate alphabetical order: 

“Amendment No. 4 Effective Date” means January 24, 2017. 

(b) Section 2.05(a) of the Credit Agreement is hereby amended to delete the reference to “agrees to make” and replace such
reference with a reference to “may in its sole discretion make”. 
 (c) Section 2.06(b) of the Credit Agreement is hereby
amended to delete each reference to “$50,000,000” appearing therein and replace each such reference with a reference to “$10,000,000”. 

 (d) Section 2.17 of the Credit Agreement is hereby amended to insert a
new clause (j) therein immediately following clause (i) thereof as follows: 
 (j) Certain FATCA Matters.
For purposes of determining withholding Taxes imposed under FATCA, from and after the Amendment No. 4 Effective Date, the Loan Parties and the Administrative Agent shall treat (and the Lenders hereby authorize the Administrative Agent to treat)
this Agreement and the Loans as not qualifying as “grandfathered obligations” within the meaning of Treasury Regulation Section 1.1471-2(b)(2)(i) or
1.1471-2T(b)(2)(i). 
 2. Conditions of Effectiveness. The effectiveness of this Amendment is
subject to the condition precedent that: 
 (a) The Administrative Agent shall have received counterparts of this Amendment duly executed by
the Borrowers, the Subsidiary Guarantors, the Required Lenders, the Issuing Banks, the Swingline Lender and the Administrative Agent. 
 3.
Representations and Warranties of the Loan Parties. Each Loan Party hereby represents and warrants as follows: 
 (a) This Amendment
and the Credit Agreement as modified hereby constitute legal, valid and binding obligations of such Loan Party and are enforceable against such Loan Party in accordance with their terms, except as may be limited by applicable bankruptcy, insolvency,
reorganization, moratorium or similar laws affecting the enforcement of creditors’ rights generally and by general principles of equity. 

(b) As of the date hereof and after giving effect to the terms of this Amendment, (i) no Default or Event of Default shall have occurred
and be continuing and (ii) the representations and warranties of such Borrower set forth in the Credit Agreement, as amended hereby, are true and correct in all material respects (provided that any representation or warranty qualified by
materiality or Material Adverse Effect is true and correct in all respects). 
 4. Reference to and Effect on the Credit Agreement.

 (a) Upon the effectiveness hereof, each reference to the Credit Agreement or any other Loan Document shall mean and be a reference to the
Credit Agreement as amended hereby. 
 (b) Each Loan Document and all other documents, instruments and agreements executed and/or delivered
in connection therewith shall remain in full force and effect and are hereby ratified and confirmed. 
 (c) Except with respect to the
subject matter hereof, the execution, delivery and effectiveness of this Amendment shall not operate as a waiver of any right, power or remedy of the Administrative Agent or the Lenders, nor constitute a waiver of any provision of the Credit
Agreement, the Loan Documents or any other documents, instruments and agreements executed and/or delivered in connection therewith. 
 5.
Consent and Reaffirmation. Without in any way establishing a course of dealing by the Administrative Agent or any Lender, each of the undersigned consents to the Amendment and reaffirms the terms and conditions of the Credit Agreement, the
Subsidiary Guaranty and any other Loan Document executed by it and acknowledges and agrees that the Credit Agreement, the Subsidiary Guaranty and each and every such Loan Document executed by the undersigned in connection with the Credit Agreement
remains in full force and effect and is hereby reaffirmed, ratified and confirmed. 

  
 2 

 6. Governing Law. This Amendment shall be construed in accordance with and governed by the
law of the State of New York. 
 7. Headings. Section headings in this Amendment are included herein for convenience of reference
only and shall not constitute a part of this Amendment for any other purpose. 
 8. Counterparts. This Amendment may be executed by
one or more of the parties hereto on any number of separate counterparts, and all of said counterparts taken together shall be deemed to constitute one and the same instrument. Signatures delivered by facsimile or PDF shall have the same force and
effect as manual signatures delivered in person. 
 [Signature Pages Follow] 

  
 3 

 IN WITNESS WHEREOF, this Amendment has been duly executed as of the day and year first above
written. 
  

			
	 WATSCO, INC.,
 as the
Company

		
	By:	 	 /s/ Ana M. Menendez

	Name:	 	Ana M. Menendez
	Title:	 	CFO and Treasurer
	
	 WATSCO CANADA, INC.,
 as the
Canadian Borrower

		
	By:	 	 /s/ Ana M. Menendez

	Name:	 	Ana M. Menendez
	Title:	 	VP and Treasurer

  
 Signature Page to
Amendment No. 4 to 
 Credit Agreement dated as of April 27, 2012 

Watsco, Inc. et al 

									
	WATSCO CANADA, INC.,	 		 	WATSCO HOLDINGS, INC.,
	as a Subsidiary Guarantor	 		 	as a Subsidiary Guarantor
					
	By:	 	/s/ Ana M. Menendez	 		 	By:	 	/s/ Ana M. Menendez
	Name:	 	Ana M. Menendez	 		 	Name:	 	Ana M. Menendez
	Title:	 	VP and Treasurer	 		 	Title:	 	VP and Treasurer
			
	WATSCO HOLDINGS II, INC.,	 		 	WATSCO HOLDINGS III, LLC,
	as a Subsidiary Guarantor	 		 	as a Subsidiary Guarantor
					
	By:	 	/s/ Ana M. Menendez	 		 	By:	 	/s/ Ana M. Menendez
	Name:	 	Ana M. Menendez	 		 	Name:	 	Ana M. Menendez
	Title:	 	VP and Treasurer	 		 	Title:	 	VP and Treasurer
			
	EAST COAST METAL DISTRIBUTORS LLC,	 		 	BAKER DISTRIBUTING COMPANY LLC,
	as a Subsidiary Guarantor	 		 	as a Subsidiary Guarantor
					
	By:	 	/s/ Ana M. Menendez	 		 	By:	 	/s/ Ana M. Menendez
	Name:	 	Ana M. Menendez	 		 	Name:	 	Ana M. Menendez
	Title:	 	VP and Asst. Secretary	 		 	Title:	 	VP and Asst. Secretary
				
	 GEMAIRE DISTRIBUTORS LLC,
 as a
Subsidiary Guarantor
	 		 		 	
					
	By:	 	/s/ Ana M. Menendez	 		 		 	
	Name:	 	Ana M. Menendez	 		 		 	
	Title:	 	VP and Asst. Secretary	 		 		 	

  
 Signature Page to
Amendment No. 4 to 
 Credit Agreement dated as of April 27, 2012 

Watsco, Inc. et al 

 
			
	 JPMORGAN CHASE BANK, N.A.,

individually as a Lender, as the Swingline Lender, as an Issuing Bank and as Administrative Agent

		
	By:	 	/s/ Blakely Engel
	Name:	 	Blakely Engel
	Title:	 	Vice President

  
 Signature Page to
Amendment No. 4 to 
 Credit Agreement dated as of April 27, 2012 

Watsco, Inc. et al 

 
			
	 BANK OF AMERICA, N.A.,
 as a Lender
and as an Issuing Bank

		
	By:	 	/s/ Julia H. Rocawich
	Name:	 	Julia H. Rocawich
	Title:	 	Senior Vice President
	
	 BANK OF AMERICA, N.A. (CANADA BRANCH),

as a Lender

		
	By:	 	/s/ Medina Sales de Andrade
	Name:	 	Medina Sales de Andrade
	Title:	 	Vice President

  
 Signature Page to
Amendment No. 4 to 
 Credit Agreement dated as of April 27, 2012 

Watsco, Inc. et al 

 
			
	 WELLS FARGO BANK, NATIONAL ASSOCIATION,

as a Lender and as an Issuing Bank

		
	By:	 	/s/ Benny Gonzalez
	Name:	 	Benny Gonzalez
	Title:	 	Vice President

  
 Signature Page to
Amendment No. 4 to 
 Credit Agreement dated as of April 27, 2012 

Watsco, Inc. et al 

 
			
	 U.S. BANK NATIONAL ASSOCIATION,
 as
a Lender

		
	By:	 	/s/ Kenneth R. Fieler
	Name:	 	Kenneth R. Fieler
	Title:	 	Vice President

  
 Signature Page to
Amendment No. 4 to 
 Credit Agreement dated as of April 27, 2012 

Watsco, Inc. et al 

 
			
	 THE NORTHERN TRUST COMPANY,
 as a
Lender

		
	By:	 	/s/ Myriam C. Bailey
	Name:	 	Myriam C. Bailey
	Title:	 	Senior Vice President

  
 Signature Page to
Amendment No. 4 to 
 Credit Agreement dated as of April 27, 2012 

Watsco, Inc. et al 

 
			
	 BRANCH BANKING & TRUST COMPANY,

as a Lender

		
	By:	 	/s/ Charles Graeub, III
	Name:	 	Charles Graeub, III
	Title:	 	Vice President

  
 Signature Page to
Amendment No. 4 to 
 Credit Agreement dated as of April 27, 2012 

Watsco, Inc. et al 

 
			
	 BANK OF MONTREAL, CHICAGO BRANCH,

as a Lender

		
	By:	 	/s/ Thomas Hasenauer
	Name:	 	Thomas Hasenauer
	Title:	 	Director
	
	 BANK OF MONTREAL, TORONTO BRANCH,

as a Lender

		
	By:	 	/s/ Peter Chauvin
	Name:	 	Peter Chauvin
	Title:	 	Director

  
 Signature Page to
Amendment No. 4 to 
 Credit Agreement dated as of April 27, 2012 

Watsco, Inc. et al 

 
			
	 REGIONS BANK,
 as a
Lender

		
	By:	 	/s/ Alfred J. Bacchi
	Name:	 	Alfred J. Bacchi
	Title:	 	Managing Director

  
 Signature Page to
Amendment No. 4 to 
 Credit Agreement dated as of April 27, 2012 

Watsco, Inc. et alExhibit 10.1

 

	

    	
 
    	
Incyte   Corporation
    
	
 
    	
 
    

 

February 17, 2017

 

The Holders set forth on the

Signature page to this Agreement

 

Re:                             0.375% Convertible Senior Notes due 2018 (CUSIP No. 45337CAK8) of Incyte Corporation (“2018 Notes”) and 1.25% Convertible Senior Notes due 2020 (CUSIP No. 45337CAL6) of Incyte Corporation (“2020 Notes”)

 

Ladies and Gentlemen:

 

By entering into this letter agreement (this “Agreement”), each party signing this Agreement under the heading “HOLDER” on the signature page hereto (each a “Holder” and, collectively, the “Holders”) and Incyte Corporation, a Delaware corporation (the “Company”) irrevocably agree as follows:

 

A.                                    The Holders shall transfer to the Company, on the Closing Date (as such term is hereinafter defined), (i) the aggregate principal amount of Company’s 2018 Notes beneficially owned by the Holder and corresponding to such Holder’s name as set forth on Schedule I hereto (as to each Holder, the “2018 Exchange Notes”) in exchange for the number of shares (the “2018 Exchange Shares”) of the Company’s common stock, $.001 par value per share (“Common Stock”), set forth on Schedule I hereto and (ii) the aggregate principal amount of the Company’s 2020 Notes beneficially owned by the Holder and corresponding to such Holder’s name as set forth on Schedule I hereto (as to each Holder, the “2020 Exchange Notes,” and together with the 2018 Exchange Notes, the “Exchanged Notes”)  in exchange for the number of shares (the “2020 Exchange Shares” and, together with the 2018 Exchange Shares, the “Exchange Shares”) of Common Stock set forth on Schedule I hereto.  Any fractional share to be issued as a result of the issuance of the Exchange Shares shall be paid in cash, in an amount equal to the relative value of any such fractional share based upon the rate of exchange used in calculating the number of Exchange Shares.

 

On the Closing Date, upon its receipt and against delivery of the Exchange Notes (either through physical delivery of the Exchange Notes to the Company or the trustee for the Exchange Notes or receipt by the Company of confirmation from The Depository Trust Company or the Registrar of the Exchange Notes, as applicable, of a book-entry transfer of the Exchange Notes into the Company’s name), the Company will deliver to the Holder the Exchange Shares (together with cash in lieu of any fractional shares) in accordance with the instructions set forth on Exhibit 1 hereto.  The certificates representing the Exchange Shares shall each in certificated form bear the following legend:

 

THIS SECURITY HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND MAY NOT BE OFFERED,

 

 

SOLD, PLEDGED OR OTHERWISE TRANSFERRED EXCEPT IN ACCORDANCE WITH THE FOLLOWING SENTENCE. BY ITS ACQUISITION HEREOF OR OF A BENEFICIAL INTEREST HEREIN, THE ACQUIRER:

 

(1)           REPRESENTS THAT IT AND ANY ACCOUNT FOR WHICH IT IS ACTING IS A “QUALIFIED INSTITUTIONAL BUYER” (WITHIN THE MEANING OF RULE 144A UNDER THE SECURITIES ACT) AND THAT IT EXERCISES SOLE INVESTMENT DISCRETION WITH RESPECT TO EACH SUCH ACCOUNT, AND

 

(2)           AGREES FOR THE BENEFIT OF INCYTE CORPORATION (THE “COMPANY”) THAT IT WILL NOT OFFER, SELL, PLEDGE OR OTHERWISE TRANSFER THIS SECURITY OR ANY BENEFICIAL INTEREST HEREIN PRIOR TO THE DATE THAT IS THE LATER OF (X) THE LATER OF (1) ONE YEAR AFTER THE LAST ORIGINAL ISSUE DATE OF THE SERIES OF NOTES UPON THE CONVERSION OF WHICH THIS SECURITY WAS ISSUED OR SUCH SHORTER PERIOD OF TIME AS PERMITTED BY RULE 144 UNDER THE SECURITIES ACT OR ANY SUCCESSOR PROVISION THERETO AND (2) 90 DAYS AFTER SUCH ENTITY CEASES TO BE AN “AFFILIATE” (WITHIN THE MEANING OF RULE 144 UNDER THE SECURITIES ACT) OF THE COMPANY AND (Y) SUCH LATER DATE, IF ANY, AS MAY BE REQUIRED BY APPLICABLE LAW, EXCEPT:

 

(A)          TO THE COMPANY OR ANY SUBSIDIARY THEREOF, OR

 

(B)          PURSUANT TO A REGISTRATION STATEMENT WHICH HAS BECOME EFFECTIVE UNDER THE SECURITIES ACT, OR

 

(C)          TO A PERSON IT REASONABLY BELIEVES TO BE A QUALIFIED INSTITUTIONAL BUYER IN COMPLIANCE WITH RULE 144A UNDER THE SECURITIES ACT, OR

 

(D)          PURSUANT TO AN EXEMPTION FROM REGISTRATION PROVIDED BY RULE 144 UNDER THE SECURITIES ACT OR ANY OTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT, OR

 

(E)           A PLEDGE TO AN AFFILIATE OF THE HOLDER SO LONG AS SUCH PLEDGEE AGREES IN WRITING TO BE BOUND BY THE TRANSFER RESTRICTIONS SET FORTH IN THIS LEGEND AND IN THE AGREEMENT DATED NOVEMBER 7, 2013 AMONG 667, L.P. (ACCOUNT #1), 667, L.P. (ACCOUNT #2), BAKER BROTHERS LIFE SCIENCES, L.P. AND 14159, L.P. AND THE COMPANY.

 

PRIOR TO THE REGISTRATION OF ANY TRANSFER IN ACCORDANCE WITH (2)(D) ABOVE, THE COMPANY AND THE TRANSFER AGENT FOR THE COMPANY’S COMMON STOCK RESERVE THE RIGHT TO REQUIRE THE DELIVERY OF SUCH LEGAL OPINIONS, CERTIFICATIONS OR OTHER EVIDENCE AS MAY REASONABLY

 

 

BE REQUIRED IN ORDER TO DETERMINE THAT THE PROPOSED TRANSFER IS BEING MADE IN COMPLIANCE WITH THE SECURITIES ACT AND APPLICABLE STATE SECURITIES LAWS. NO REPRESENTATION IS MADE AS TO THE AVAILABILITY OF ANY EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES ACT.

 

Each Holder hereby agrees that the aggregate principal amount and all accrued unpaid interest on the Exchanged Notes shall be cancelled in connection with the exchange set forth in this Section A and that Holder will not be entitled to any other payment or amount with respect to the Exchanged Notes.

 

The certificates representing the Exchange Shares shall be delivered to the Holders in physical form to the following address: Goldman, Sachs & Co., GSS — Prime Brokerage, 200 West Street, 6th floor, New York, NY 10282, Attn: Zohar Kastner.

 

The issuance of the Exchange Shares to Holder will be made without registration of such Exchange Shares under the Securities Act of 1933 (together with the rules and regulations thereunder, the “Securities Act”), in reliance upon the exemption therefrom provided by Section 3(a)(9) of the Securities Act.  Holder acknowledges that the Company is relying upon the truth and accuracy of, and the Holder’s compliance with, its representations, warranties, agreements, acknowledgments and understandings set forth herein in order to determine the availability of such exemption and the eligibility of the Holder for the issuance of the Exchange Shares.

 

B.            The “Closing Date” shall mean the third business day following the date of this Agreement or at such other time on the same date or such other date as the parties may agree in writing.

 

C.            Each Holder hereby represents and warrants to the Company as follows:

 

The Holder has good and valid title to the Exchanged Notes, free and clear of any liens, claims, encumbrances, security interests, options, charges and restrictions of any kind.  The Holder will, upon request, execute and deliver any additional documents or take any additional actions reasonably deemed by the Company to be necessary to complete the transactions contemplated herein.

 

The Holder is in the business of acquiring, disposing of and holding securities, whether as principal or agent.  The Holder understands the Exchange Shares have not been and will not be registered under the Securities Act or the securities laws of any state of the United States and that the exchange contemplated hereby is being made in reliance on an exemption from such registration pursuant to Section 3(a)(9) of the Securities Act and, as such, the Exchange Shares will be subject to any transfer restrictions applicable to the Exchanged Notes.  The Holder has not acted on behalf of the Company.  The Holder was not solicited by anyone on behalf of the Company (other than employees of the Company) to enter into this transaction, and the Holder has not solicited any other holder of the 2018 Notes or the 2020 Notes to participate in a similar transaction.

 

The Holder acknowledges that (i) it has reviewed the Company’s filings with the Securities and Exchange Commission, and (ii) it has had the opportunity to receive and review all information regarding the Company and its future plans or prospects that the Holder considered necessary in deciding whether to enter into the transaction contemplated by this Agreement and to exchange the Exchanged Notes.

 

The Holder has reviewed with the Holder’s own tax advisors the federal, state and local tax consequences of the transactions contemplated by this Agreement.  The Holder is relying solely on such advisor and is not relying (for purposes of making any investment decision or otherwise) upon any

 

 

advice, counsel or representations (whether written or oral) of the Company or any of its agents or advisors (other than the representations and warranties of the Company contained in this Agreement).  The Holder understands that the Holder (and not the Company) shall be responsible for the Holder’s own tax liability that may arise as a result of the transactions contemplated by this Agreement.

 

D.            The Company represents and warrants to each Holder that the Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware.  The Company has all requisite corporate power and authority to enter into this Agreement, to perform its obligations hereunder and to consummate the transactions contemplated hereby.  All corporate acts and other proceedings required to be taken by the Company to authorize the execution, delivery and performance of this Agreement and the consummation of the transactions contemplated hereby have been duly and properly taken.  This Agreement has been duly executed and delivered by the Company and constitutes a legal, valid and binding obligation of the Company, enforceable against the Company in accordance with its terms, except as enforcement may be limited by equitable principles or by bankruptcy, fraudulent conveyance, insolvency, reorganization, moratorium, or similar laws relating to or limiting creditors’ rights generally. The execution and delivery of this Agreement does not, and the performance and consummation of the transactions contemplated hereby will not (i) result in a violation of the Certificate of Incorporation or Bylaws of the Company as currently in effect, (ii) conflict with or result in any default or violation of any agreement to which the Company is a party, or (iii) result in a violation of any law, rule, regulation, judgment, order or decree applicable to the Company or by which any property of the Company is bound or affected, except with respect to clauses (ii) or (iii) for any conflicts, defaults or violations that would not materially affect the performance of the Company’s obligations hereunder. The Exchange Shares have been duly authorized and, when issued and delivered in accordance with the terms and for the consideration set forth in this Agreement, will be validly issued, fully paid and nonassessable.

 

E.            Each of the Company and each Holder agree to promptly execute and deliver such further agreements and instruments and take such further actions, as the other may reasonably request in order to carry out the purposes and intent of this Agreement.

 

F.             This Agreement may be executed in one or more counterparts, each of which when executed shall be deemed an original, but all of which taken together shall constitute one and the same instrument.

 

G.            This Agreement shall in all respects be construed in accordance with and governed by the substantive laws of the State of New York, without reference to its conflicts of law rules.

 

(Signature Pages Follow)

 

 

	
 
    	
INCYTE CORPORATION
    
	
 
    	
 
    	
 
    
	
 
    	
By: 
    	
/s/ David W. Gryska
    
	
 
    	
 
    	
Name:  David W. Gryska
    
	
 
    	
 
    	
Title:  Executive Vice President and
    
	
 
    	
 
    	
Chief Financial Officer
    

 

(Signature Page to Debt Exchange Agreement — Baker Brothers)

 

 

 

	
 
    	
Agreed:
    
	
 
    	
 
    
	
 
    	
HOLDERS:
    
	
 
    	
 
    
	
 
    	
667, L.P. (account   #1),
    
	
 
    	
 
    
	
 
    	
BY:   BAKER   BROS. ADVISORS LP, management company and investment   adviser to 667, L.P., pursuant to authority   granted to it by Baker Biotech Capital, L.P., general partner to 667, L.P.,   and not as the general partner.
    
	
 
    	
 
    	
 
    
	
 
    	
By: 
    	
/s/ Scott Lessing
    
	
 
    	
Scott Lessing
    
	
 
    	
President
    
	
 
    	
 
    
	
 
    	
 
    
	
 
    	
667, L.P. (account   #2),
    
	
 
    	
 
    
	
 
    	
BY:    BAKER BROS. ADVISORS LP,   management company and investment adviser to 667, L.P.,   pursuant to authority granted to it by Baker Biotech Capital, L.P., general   partner to 667, L.P., and not as the general partner.
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
By: 
    	
/s/ Scott Lessing
    
	
 
    	
Scott Lessing
    
	
 
    	
President
    
	
 
    	
 
    
	
 
    	
 
    
	
 
    	
BAKER   BROTHERS LIFE SCIENCES, L.P.
    
	
 
    	
 
    
	
 
    	
By:     BAKER BROS. ADVISORS   LP, , management   company and investment adviser to Baker Brothers Life   Sciences, L.P., pursuant to authority granted to it by Baker   Brothers Life Sciences Capital, L.P., general partner to Baker Brothers Life   Sciences, L.P., and not as the general partner.
    
	
 
    	
 
    
	
 
    	
 
    
	
 
    	
By:
    	
 /s/ Scott Lessing
    
	
 
    	
Scott Lessing
    
	
 
    	
President
    
	
 
    	
 
    

 

(Signature Page to Debt Exchange Agreement)

 

 

 

	
 
    	
14159, L.P.,
    
	
 
    	
 
    
	
 
    	
By:    BAKER BROS. ADVISORS LP, management company and investment adviser to 14159,   L.P., pursuant to authority granted to it by 14159 Capital, L.P.,   general partner to 14159, L.P., and not as the general partner.
    
	
 
    	
 
    
	
 
    	
 
    	
 
    
	
 
    	
By: 
    	
/s/ Scott Lessing
    
	
 
    	
Scott Lessing
    
	
 
    	
President
    
	
 
    	
 
    

 

(Signature Page to Debt Exchange Agreement)

 

 

Schedule I

 

HOLDER: 667, L.P.

 

Aggregate Principal Amount of the 2018 Notes transferred to the Company: $25,000,000

 

2018 Exchange Shares:                491,338.3521

 

Aggregate Principal Amount of the 2020 Notes transferred to the Company: $25,000,000

 

2020 Exchange Shares:                502,779.5236

 

HOLDER: Baker Brothers Life Sciences, L.P.

 

Aggregate Principal Amount of the 2018 Notes transferred to the Company: $228,326,000

 

2018 Exchange Shares:                4,487,412.8229

 

Aggregate Principal Amount of the 2020 Notes transferred to the Company: $243,450,000

 

2020 Exchange Shares:                4,896,067.0011

 

HOLDER: 14159, L.P.

 

Aggregate Principal Amount of the 2018 Notes transferred to the Company: $5,674,000

 

2020 Exchange Shares:                111,514.1524

 

Aggregate Principal Amount of the 2020 Notes transferred to the Company: $6,050,000

 

2020 Underlying Shares:           121,672.6447

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