Document:

exv10w1

 

Exhibit 10.1

FIRST AMENDMENT TO THE EMPLOYMENT AGREEMENT

BY AND BETWEEN

HUMAN GENOME SCIENCES, INC. AND H. THOMAS WATKINS

     WHEREAS, HUMAN GENOME SCIENCES, INC. (the “Company”) and H. THOMAS WATKINS (“Executive”) have
entered into an employment agreement, dated as of November 21, 2004 (the “Employment Agreement”);

     WHEREAS, the Company and Executive now desire to amend the Employment Agreement to comply with
Section 409A of the Internal Revenue Code of 1986, as amended, and the Treasury regulations and
other guidance promulgated thereunder;

     WHEREAS, Section 14 of the Employment Agreement provides that all amendments must be in
writing signed by both parties;

     NOW, THEREFORE, the Employment Agreement is hereby amended as follows:

     1. Section 4(b) is hereby amended by adding to the end thereof the following sentence:

The bonus award shall be paid on or before March 15 of the year after the year in
which the bonus award was earned.

     2. Section 4(c)(iv) is hereby amended by modifying the first sentence thereof as follows:

All options granted to Executive to purchase common stock of the Company and all
other equity based awards granted under any plan, program or arrangement maintained
by the Company, shall become fully vested and exercisable as of the Effective Date
of a Change of Control (as such terms are defined in the Company’s Second Amended
and Restated Key Executive Severance Plan in the form attached hereto as Exhibit B
(the “Severance Plan”), which is incorporated herein by reference), to the extent
such options and equity based awards are then outstanding.

     3. Effective as of November 21, 2007, Section 4(h)(ii) is hereby amended in its entirety as
follows:

     (ii) The Company will also reimburse Executive for weekly roundtrip coach
class commercial air travel to Chicago, Illinois and related expenses through
November 21, 2008, or until the earlier relocation of his family to the
Maryland/Virginia/Washington D.C. area; such reimbursement of related expenses shall
be in accordance with the Company’s policies then in existence.

 

 

     4. Sections 5(e)(i) and (ii) are hereby amended in their entirety as follows:

     (i) For purposes of this Agreement, the term “Good Reason” means, without
Executive’s written consent: (A) removal from, or failure to be appointed, elected,
reappointed, or reelected to the Board or Executive’s principal position; (B)
material diminution in Executive’s title, position, duties or responsibilities, or
the assignment to Executive of duties that are inconsistent, in a material respect,
with the scope of duties and responsibilities associated with Executive’s position
under this Agreement; (C) material reduction in Executive’s Base Salary or target
bonus opportunity; (D) relocation of Executive’s principal workplace to a location
which is more than fifty (50) miles from Rockville, Maryland; or (E) any material
failure by the Company to require any successor to assume the terms of this
Agreement in the absence of a successor agreement acceptable to Executive. For
purposes of clauses (A), (B) or (C) of the preceding sentence, an isolated and
inadvertent action not taken in bad faith and which is remedied by the Company
promptly after receipt of written notice thereof given by Executive shall be
excluded. Notwithstanding the foregoing, in the event that Executive suffers,
without his written consent, a material diminution of title, position, duties or
responsibilities as a result of the Company becoming a subsidiary of another
corporation or due to a change in the reporting hierarchy incident thereto, then
such material diminution shall constitute Good Reason under clause (B) of this
Section 5(e)(i), only if Executive delivers a Notice of Termination for Good Reason
(as defined below) to the Company within thirty (30) days after the occurrence of
the event giving rise to such material diminution, the Company or its successor
fails to remedy such material diminution within thirty (30) days after receipt of
such notice, and Executive agrees, upon the request of the Company or its successor,
to continue his employment for up to a maximum of ninety (90) days after delivering
such Notice of Termination for Good Reason.

     (ii) A termination of employment by Executive for Good Reason shall be
effected by giving the Company written notice (a “Notice of Termination for Good
Reason”) of the termination, setting forth in reasonable detail the specific conduct
of the Company that constitutes Good Reason and the specific provision(s) of this
Agreement on which the Executive relies no later than ninety (90) days after the
initial occurrence of such specific conduct of the Company. A termination of
employment by the Executive for Good Reason shall be effective thirty-one (31) days
following the date when the Notice of Termination for Good Reason is given, unless,
if applicable, the event constituting Good Reason is remedied by the Company prior
to that date. Actions by the Company that constitute Good Reason shall be
disregarded in the calculation of termination benefits described in Section 6.
Notwithstanding anything provided in this Section 5(e), Good Reason shall not exist
unless Executive’s termination of employment occurs no later than two (2) years
following the initial occurrence of any of the conditions provided under Section
5(e)(i).

 

 

     5. Section 5(f) is hereby amended in its entirety as follows:

(f) DATE OF TERMINATION. The term “Date of Termination” means the earliest of: (i)
the date of Executive’s death; (ii) the date on which the Company gives written
notice of termination of employment to Executive due to his having become Totally
Disabled; (iii) the date on which the termination of Executive’s employment by the
Company for Cause or without Cause or by Executive for Good Reason or without Good
Reason, is effective; or (iv) the last day before the next subsequent anniversary of
the Effective Date after a notice of nonrenewal and termination of employment is
given timely by the Company or Executive. Such Date of Termination, in each case,
is the date as of which the Company and Executive reasonably anticipate that no
further services will be performed by Executive and shall be construed as the date
Executive first incurs a “separation from service” as defined under Section 409A of
the Internal Revenue Code of 1986, as amended (the “Code”). Upon Executive’s
termination of employment for any reason, Executive shall immediately resign from
the Board and from all other offices and positions he holds with the Company and its
subsidiary and affiliate companies.

     6. Sections 6(a) and 6(a)(i) are hereby amended in their entirety as follows:

     (a) TERMINATION BY REASON OF DEATH. In the event that Executive’s employment
is terminated by reason of Executive’s death, the Company shall pay the following
amounts and provide the following benefits to Executive’s beneficiary(ies) or
estate, as applicable, within 90 days following Executive’s death:

     (i) All accrued but unpaid Base Salary; if the Date of Termination occurs
before March 15, any earned but unpaid bonuses for the immediately preceding
year; all earned or vested incentive compensation or benefits; all accrued but
unpaid expenses required to be reimbursed under this Agreement; and all accrued but
unused vacation time (collectively referred to as “Accrued Compensation”).

     7. Section 6(b)(ii) is hereby amended in its entirety as follows:

     (ii) A pro rata bonus payment for the year in which Executive’s termination of
employment due to Total Disability occurs equal to the amount of Executive’s target
bonus for the then current fiscal year multiplied by a fraction, the numerator of
which is the number of days during the year that transpired before the Date of
Termination and the denominator of which is three hundred sixty five (365). The
bonus payment will be paid to Executive within 30 days following the Date of
Termination, unless Executive is a “specified employee” (as defined under Section
409A of the Code and determined in good faith by the Compensation Committee), in
which case such bonus payment will be delayed for six months as provided under
Section 18(i)(vi) to the extent required under Section 409A of the Code.

 

 

     8. Section 6(d)(ii) is hereby amended in its entirety as follows:

     (ii) A pro rata bonus payment the amount of which will be the amount of
Executive’s target bonus for the then current fiscal year multiplied by a fraction,
the numerator of which is the number of days during the year of his termination that
transpired before the Date of Termination, and the denominator of which is three
hundred sixty five (365). The bonus payment will be paid to Executive within 30
days following the Date of Termination, unless Executive is a “specified employee”
(as defined under Section 409A of the Code and determined in good faith by the
Compensation Committee), in which case such bonus payment will be delayed for six
months as provided under Section 18(i)(vi).

     9. Sections 6(f)(ii) and (iii) are hereby amended in their entirety as follows:

     (ii) A pro rata bonus payment for the year in which the Date of Termination
occurs equal to the amount of Executive’s target bonus for the then current fiscal
year multiplied by a fraction, the numerator of which is the number of days during
the year that transpired before the Date of Termination and the denominator of which
is three hundred sixty five (365). The bonus payment will be paid to Executive
within 30 days following the Date of Termination, unless Executive is a “specified
employee” (as defined under Section 409A of the Code and determined in good faith by
the Compensation Committee), in which case such bonus payment will be delayed for
six months as provided under Section 18(i)(vi).

     (iii) Provided that the Company is the first party that elected not to
renew the Agreement by notifying Executive in writing of its intention not to renew
in accordance with Section 2 of this Agreement and Executive was willing and able to
renew this Agreement on substantially the same terms and conditions, continuation of
Executive’s Base Salary during the twenty-four (24) month period that commences on
the Date of Termination. Such payments shall be paid at the same time and in the
same manner as Base Salary would have been paid if Executive had remained actively
employed by the Company until the end of such twenty-four (24) month period.

     10. Section 18(c) is hereby amended in its entirety as follows:

     (c) TERMINATION OF AGREEMENT. This Agreement shall terminate upon the
termination of Executive’s employment, except that terms of this Agreement which
must survive the termination of this Agreement in order to be effectuated (including
the provisions of Sections 6, 7, 8, 9, 13, 15 and 18(i)) shall survive until, by
their terms, such provisions are no longer operative. Upon the termination of the
Executive’s employment, Executive consents to the notification by the Company to the
Executive’s new employer of Executive’s obligations under this Agreement.

 

 

     11. Section 18 is hereby amended by adding to the end thereof the following new subsection
(i):

(i) 409A COMPLIANCE.

     (i) This Agreement is intended to comply with, or otherwise be exempt from,
Section 409A of the Code and any regulations and Treasury guidance promulgated
thereunder.

     (ii) The Company and Executive agree that they will execute any and all
amendments to this Agreement as they mutually agree in good faith may be necessary
to ensure compliance with the provisions of Section 409A of the Code.

     (iii) The preceding provisions, however, shall not be construed as a guarantee
by the Company of any particular tax effect to Executive under this Agreement. The
Company shall not be liable to Executive for any payment made under this Agreement,
at the direction or with the consent of Executive, which is determined to result in
an additional tax, penalty, or interest under Section 409A of the Code, nor for
reporting in good faith any payment made under this Agreement as an amount
includible in gross income under Section 409A of the Code.

     (iv) For purposes of Section 409A of the Code, the right to a series of
installment payments under this Agreement shall be treated as a right to a series of
separate payments.

     (v) With respect to any reimbursement of expenses of, or any provision of
in-kind benefits to, Executive, as specified under this Agreement, such
reimbursement of expenses or provision of in-kind benefits shall be subject to the
following conditions: (1) the expenses eligible for reimbursement or the amount of
in-kind benefits provided in one taxable year shall not affect the expenses eligible
for reimbursement or the amount of in-kind benefits provided in any other taxable
year, except for any medical reimbursement arrangement providing for the
reimbursement of expenses referred to in Section 105(b) of the Code; (2) the
reimbursement of an eligible expense shall be made no later than the end of the year
after the year in which such expense was incurred; and (3) the right to
reimbursement or in-kind benefits shall not be subject to liquidation or exchange
for another benefit.

     (vi) If a payment obligation under this Agreement arises on account of
Executive’s termination of employment while he is a “specified employee” (as defined
under Section 409A of the Code and determined in good faith by the Compensation
Committee), any payment of “deferred compensation” (as defined under Treasury
Regulation Section 1.409A-1(b)(1), after giving effect to the exemptions in Treasury
Regulation Sections 1.409A-1(b)(3) through (b)(12)) shall accrue with interest and
shall be made within 15 days after the end of the six-month period beginning on the
date of such termination of employment or, if

 

 

earlier, within 15 days after appointment of the personal representative or
executor of Executive’s estate following his death. For purposes of the preceding
sentence, interest shall accrue at the prime rate of interest published in the
northeast edition of The Wall Street Journal on the date of Executive’s termination
of employment.

     12. In all other respects, the Employment Agreement is hereby ratified and confirmed.

     IN WITNESS WHEREOF, the Company and Executive hereby amend the Employment Agreement, effective
as of the first day of January, 2008, except as otherwise provided herein.

	 	 	 	 	 	 	 	 	 
	H. THOMAS WATKINS	 	 	 	WITNESS:	 	 
	 
	 	 	 	 	 	 	 	 
	/s/ H. Thomas Watkins	 	 	 	James H. Davis, Ph.D.	 	 
	 	 	 	 	 	 	 
	 
	 	 	 	 	 	 	 	 
	HUMAN GENOME SCIENCES, INC.	 	 	 	ATTEST:	 	 
	 
	 	 	 	 	 	 	 	 
	By:

	 	Susan D. Bateson
	 	 	 	Rose Hadidian	 	 
	 

	 	 
	 	 	 	 	 	 
	Title:

	 	Senior Vice President, Human Resourcesexv10w2

 

Exhibit 10.2

HUMAN GENOME SCIENCES, INC.

SECOND AMENDED AND RESTATED KEY EXECUTIVE SEVERANCE PLAN

I. Preamble and Statement of Purpose.

     The purpose of this Plan is to assure Human Genome Sciences, Inc. (“Human Genome”) and its
subsidiaries (Human Genome, together with its subsidiaries, the “Corporation”) of the continued
dedication, loyalty, and service of, and the availability of objective advice and counsel from, key
employees of the Corporation notwithstanding the possibility, threat or occurrence of a bid or
other action to take over control of the Corporation.

     In the event Human Genome receives any proposals from a third party concerning a possible
business combination with Human Genome, or acquisition of Human Genome’s equity securities or a
substantial portion of its assets, the Board of Directors of Human Genome (the “Board”) believes
that it would be imperative that the Board, the Corporation and its senior management be able to
rely on the Corporation’s key employees to continue in their positions and be available for advice,
if requested, without concern that those individuals might be distracted by the personal
uncertainties and risks created by such a proposal, or be influenced to consider other employment
opportunities or prospects because of such uncertainties or risks.

     Should Human Genome receive any such proposals, in addition to their regular duties, such key
employees, in light of their experience and knowledge gained within that portion of the business in
which they are principally engaged, may be called upon to assist in the assessment of proposals,
advise senior management and the Board as to whether such proposals would be in the best interest
of Human Genome and its shareholders, and take such other actions as the Board might determine to
be appropriate.

II. Eligible Executives.

     The following individuals are eligible to participate in this Plan: (i) the Chief Executive
Officer and the President of Human Genome, and (ii) those key employees of the Corporation who are
from time to time designated by the Compensation Committee of the Board (the “Compensation
Committee”) as eligible to participate in this Plan.

     Each eligible employee shall become a Participant in the Plan upon his or her execution of a
letter agreement in the form, or substantially in the form, of Exhibit A, attached to and

 

 

incorporated in this Plan (the “Letter Agreement”). The executed Letter Agreement shall constitute
the Participant’s agreement to the terms and conditions of participation in this Plan and shall set
forth the amount of the Lump Sum Cash Payment under Section 3.2.2, the length of the Coverage
Period for welfare benefit continuation under Section 3.2.3, and such other terms and conditions as
the Compensation Committee may determine applicable to the Participant.

     A Participant who is no longer employed by the Corporation shall cease to be a Participant in
the Plan, unless the Participant’s employment ceases (i) within eighteen (18) months after the
Effective Date (as defined in Section 3.1.3) or (ii) during any period of time when the Board has
knowledge that any third person has taken steps reasonably calculated to effect a Change of Control
(as defined in Section 3.1.2) until, in the opinion of the Board, the third party has abandoned or
terminated its efforts to effect a Change of Control. Any decision by the Board that, in its
opinion, a third party has or has not taken steps reasonably calculated to effect a Change of
Control, or that, in its opinion, the third person has abandoned or terminated its efforts to
effect a Change of Control, shall be conclusive and binding on the Participants.

III. Plan Provisions.

3.1 Definitions. The following terms, as used in this Plan with capitalized first letters,
shall have the meanings as provided in this Section 3.1:

     3.1.1. “Cause”. “Cause” means (i) the Participant’s willful and continued failure
substantially to perform the duties of his or her position (other than as a result of disability,
as defined in Section 72(m)(7) of the Internal Revenue Code of 1986, as amended (the “Code”), or as
a result of termination by the Participant for Good Reason) after written notice to the Participant
by the Board specifying such failure, provided that such “Cause” shall have been found by a
majority vote of the Board after at least ten (10) days’ written notice to the Participant
specifying the failure on the part of the Participant and after an opportunity for the Participant
to be heard at a meeting of the Board; (ii) any willful act or omission by the Participant
constituting dishonesty, fraud or other malfeasance, and any act or omission by the Participant
constituting immoral conduct, which in any such case is injurious to the financial condition or
business reputation of the Corporation; or (iii) the Participant’s indictment of a felony under the
laws of the United States or any state thereof or any other jurisdiction in which the Corporation
conducts business. For purposes of this definition, no act or failure to act shall be deemed
“willful” unless
effected by the Participant not in good faith and without a reasonable belief that such action
or failure to act was in or not opposed to the best interests of the Corporation.

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     3.1.2. “Change of Control”. “Change of Control” means the earliest to occur of any of
the following events, construed in accordance with Code section 409A:

     (i) Any one person or more than one person acting as a group acquires, or has acquired during
the twelve (12) month period ending on the date of the most recent acquisition by such person or
group, beneficial ownership of more than fifty percent (50%) of the total voting power of Human
Genome’s then outstanding voting securities;

     (ii) A majority of the members of the Board is replaced during any twelve (12) month period
by directors whose appointment or election is not endorsed or approved by a majority of the members
of the Board who were members of the Board prior to the initiation of the replacement; or

     (iii) Any one person or more than one person acting as a group acquires, or has acquired
during the twelve (12) month period ending on the date of the most recent acquisition by such
person or group, assets of Human Genome that have a total gross fair market value of fifty percent
(50%) or more of the total gross fair market value of all of the assets of Human Genome immediately
prior to the initiation of the acquisition.

     3.1.3. “Effective Date”. “Effective Date” means the date on which a Change of Control
occurs. In the event of a Change of Control occurring within eighteen (18) months after a prior
Change of Control, “Effective Date” shall mean, for a Participant whose employment terminates prior
to the subsequent Change of Control, the date on which the prior Change of Control occurs, and for
all other Participants, the date on which the subsequent Change of Control occurs. Notwithstanding
anything in this Plan to the contrary, if a Participant’s employment with the Corporation had
terminated prior to the date on which the Change of Control occurred, and if it is reasonably
demonstrated by the Participant to the Board that such termination of employment either was at the
request of a third party who had taken steps reasonably calculated to effect the Change of Control
or otherwise arose in connection with or in anticipation of the Change of Control, then, for all
purposes of this Plan, “Effective Date” shall mean, with respect to such Participant only, the date
immediately prior to the date of such termination of employment.

     3.1.4. “Good Reason”. “Good Reason” means, without the Participant’s consent, (i)
removal from, or failure to be reappointed or reelected to, the Participant’s principal positions
immediately prior to the Change of Control (other than as a result of a promotion); (ii) a
material diminution in the Participant’s title, position, duties or responsibilities, or the
assignment to the Participant of duties that are inconsistent, in a material respect, with the
scope of duties and

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responsibilities associated with the Participant’s position immediately prior
to the Change of Control; (iii) a material reduction in the Participant’s base compensation, as in
effect immediately preceding the Effective Date, or target bonus opportunity; (iv) relocation of
the Participant’s principal workplace to a location which is more than fifty (50) miles from the
Participant’s principal workplace on the Effective Date; or (v) any material failure by Human
Genome to comply with and satisfy the requirements of Section 3.5.6, provided that the successor
shall have received at least ten (10) days’ prior written notice from Human Genome or the
Participant of the requirements of Section 3.5.6, and shall have failed to remedy such material
failure within thirty (30) days after receipt of such notice. For purposes of clauses (i), (ii) or
(iii) of the preceding sentence, an isolated and inadvertent action not taken in bad faith and
which is remedied by Human Genome promptly after receipt of notice thereof given by the Participant
shall be excluded. For purposes of clause (ii), no material diminution of title, position, duties
or responsibilities shall be deemed to occur solely because Human Genome becomes a subsidiary of
another corporation or change in the reporting hierarchy incident thereto. For the purposes of
clauses (i), (ii), (iii), and (iv), Good Reason shall not exist unless the Participant notifies the
Corporation of the existence of the condition specified under the applicable clause no later than
ninety (90) days after the initial existence of any such condition, and the Corporation fails to
remedy such condition within thirty (30) days after receipt of such notice. Notwithstanding the
foregoing, Good Reason shall not exist unless the termination of employment occurs no later than
two years following the initial existence of any of the conditions provided under this Section
3.1.4.

3.2 Benefits.

     3.2.1. Triggering Event. In the event the Participant’s employment with the
Corporation is terminated without Cause by the Corporation, or for Good Reason by the Participant,
on or within eighteen (18) months after the Effective Date, Human Genome shall (in addition to any
compensation or benefits to which the Participant may otherwise be entitled under any other
agreement, plan or arrangement with the Corporation, other than amounts excluded by Section 3.5.2)
make the payments and provide the benefits to the Participant as specified under Sections 3.2.2 and
3.2.3. Solely for purposes of this Section 3.2.1, a Participant’s employment with the Corporation
will be deemed to have terminated on the earlier of the date the Participant’s employment with the
Corporation ceases or the date that written notice of any such termination is
received by the Participant or by the Corporation, as the case may be, even though the parties
may agree in connection therewith that the Participant’s employment with the Corporation will
continue for a specified period thereafter. The failure by the Participant or the

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Corporation to set forth in any such notice sufficient facts or circumstances showing Good Reason or Cause, as the
case may be, shall not waive any right of the Participant or the Corporation or preclude either
party from asserting such facts or circumstances in the enforcement of any such right.

     3.2.2. Lump Sum Cash Payment. On or within 30 days after the Participant’s last day
of service with the Corporation, Human Genome shall pay to the Participant as compensation for
services rendered to the Corporation a Lump Sum Cash Payment (subject to any applicable payroll or
other taxes required to be withheld) in the amount determined in accordance with the Letter
Agreement, subject to Sections 3.4 and 3.5.2.

     3.2.3. Welfare Benefit Continuation. The Participant’s (and, where applicable, the
Participant’s dependents’) participation in the group medical, dental, life (including split
dollar, if any) and disability plans maintained by the Corporation shall be continued on
substantially the same basis as if the Participant were an employee of the Corporation until the
end of the Coverage Period as set forth in the Letter Agreement. In the event that Human Genome is
unable for any reason to provide for the Participant’s (and, where applicable, the Participant’s
dependents’) continued participation in one or more of such plans during the Coverage Period, Human
Genome shall pay or provide at its expense equivalent benefit coverage for the remainder of the
Coverage Period. The Coverage Period shall, to the extent allowed by law, be taken into account as
a period of continuation coverage for purposes of Part 6 of Title I of the Employee Retirement
Income Security Act of 1974, as amended, and for purposes of any other obligation of the
Corporation to provide any continued coverage to the Participant (and, where applicable, the
Participant’s dependents) under any group medical, dental, life or disability plan. The
Corporation shall also pay to the Participant at least annually an amount which shall be sufficient
on an after-tax basis to compensate the Participant for all additional taxes, other than those
imposed under Section 409A of the Code, incurred by reason of any income realized as a result of
the continued coverage under this Section, to the extent such taxes result from the Participant’s
status as a non-employee and would not be incurred if Participant was an employee of the
Corporation, on a grossed-up basis, at the highest marginal income tax rate for individuals (the
“Tax Gross-Up Payment”). The Tax Gross-Up Payment shall be made no later than the end of the year
after the year in which the Participant remitted the taxes.

     3.2.4. Accelerated Vesting of Options. All options granted to a Participant to
purchase common stock of Human Genome under any plan, program or arrangement maintained by Human
Genome, shall become fully vested and exercisable as of the Effective Date of a Change

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of Control as defined in Section 3.1.2, to the extent such options are then outstanding. The preceding
sentence shall not apply with respect to any option if: (i) in connection with the Change of
Control, another entity (a) shall have assumed or will assume the obligations of Human Genome with
respect to such option, or (b) shall have issued or will issue one or more options of equivalent
economic value with equivalent vesting conditions to replace such option; and (ii) the assumed or
replacement option as set forth in clause (i), pursuant to its terms, shall vest as of the date the
Participant’s employment with the Corporation is terminated without Cause by the Corporation, or
for Good Reason by the Participant, on or within eighteen (18) months after the Effective Date.
The Board shall have sole discretion in the determination of whether a replacement option is of
equivalent economic value to the replaced option.

3.3 Adjustment of Lump Sum Cash Payment.

     3.3.1. Adjustment. Notwithstanding anything in this Plan or any Letter Agreement to
the contrary, in the event the Law or Accounting Firm (as defined in Section 3.3.2) shall determine
that the Lump Sum Cash Payment and any other payment or distribution in the nature of compensation
by the Corporation to or for the benefit of the Participant, whether paid or payable or distributed
or distributable pursuant to the terms of this Plan or otherwise (the Lump Sum Cash Payment,
together with such other payments and distributions, the “Payments”), would cause any portion of
such Payments to be subject to the excise tax imposed by Section 4999 (or any successor provision)
of the Code (the “Parachute Payments”), the Participant’s Lump Sum Cash Payment shall be reduced to
the extent necessary (but not below zero) so that no portion of the Payments shall be subject to
the excise tax imposed by Section 4999 of the Code, provided that no such reduction shall be made
if the Participant’s Payments, after the reduction and after the application of Federal income tax
at the highest rate applicable to individual taxpayers, would not be greater than the present value
(determined in accordance with Section 280G of the Code) of the Payments before the reduction but
after the application of (i) excise tax under Section 4999 of the Code and (ii) Federal income tax
at the highest rate applicable to individual taxpayers.

     3.3.2. Determination. All determinations required to be made under this Section 3.3,
including the assumptions to be utilized in arriving at such determination, shall be made by DLA
Piper US LLP or other nationally recognized law or accounting firm (the “Law or Accounting
Firm”), which shall provide detailed supporting calculations both to Human Genome and the
Participant (i) within fifteen (15) business days after the receipt of a notice from the
Participant that he or she may have a Parachute Payment, or (ii) at such earlier time as may be
requested by

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Human Genome. The Law or Accounting Firm may employ and rely upon the opinions of
actuarial or accounting professionals to the extent it deems necessary or advisable. In the event
that the Law or Accounting Firm determines, for any reason, that it is unable to perform such
services, or declines to do so, Human Genome shall select another nationally recognized law or
accounting firm to make the determinations required under this Section (which law or accounting
firm shall then be referred to as the Law or Accounting Firm hereunder). All fees and expenses of
the Law or Accounting Firm shall be borne solely by Human Genome. Any determination by the Law or
Accounting Firm shall be binding upon Human Genome and the Participant.

3.4 Terms and Conditions of Participation

     3.4.1. Conditions of Participation. As a condition to being covered by the Plan, each
Participant, by executing the Letter Agreement, shall acknowledge and agree that (i) except as may
otherwise be expressly provided under any other executed agreement between the Participant and the
Corporation, nothing contained in this Plan (including, but not limited to, using the term “Cause”
to determine benefits under this Plan) is intended to change the fact that the employment of the
Participant by the Corporation is “at will” and, prior to the Effective Date, may be terminated by
either the Participant or the Corporation at any time, (ii) the Participant shall be bound by, and
comply with, the requirements of Sections 3.5.3 and 3.5.4, and (iii) the Participant consents to
the modifications to the options as provided in Section 3.2.4. Moreover, except as provided in
Section 3.1.3, if prior to the Effective Date, the Participant’s employment with the Corporation
terminates, then the Participant shall have no further rights under this Plan.

     3.4.2. Non-Duplication. As a condition to being covered by this Plan, and
notwithstanding any other prior agreement to the contrary, each Participant, by executing the
Letter Agreement, shall agree that the payments under this Plan shall be in lieu of any severance
or similar payments that otherwise might be payable under any plan, program, policy or agreement.

     3.4.3. Amendment and Termination. The Plan may not be amended or terminated after the
Effective Date. Prior to the Effective Date, the Compensation Committee of the Board (the
“Compensation Committee”) may, in its sole discretion, modify or amend this Plan in any respect, or
terminate the Plan (including with respect to individuals then participating in the Plan), provided
(i) such action is taken and becomes effective at least one (1) year prior to the
Effective Date and such action is communicated to the Participants prior to the Effective
Date, or (ii) such actions do not reduce the amount or defer the receipt of any payment or benefit

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provided under this Plan to a Participant without the Participant’s written consent.
Notwithstanding the foregoing provisions of this Section 3.4.3, the Plan may be amended by the
Compensation Committee at any time, retroactively if required, if found necessary, in the opinion
of the Compensation Committee, in order to conform the Plan to the provisions of section 409A of
the Code and the Treasury Regulations or other authoritative guidance issued thereunder and to
conform the Plan to the provisions and other requirements of any applicable law. No such amendment
shall be considered prejudicial to any interest of a Participant under the Plan or require the
Participant’s written consent. The Corporation shall promptly notify affected Participants of any
such amendment adopted by the Compensation Committee.

3.5 General.

     3.5.1. Indemnification. If litigation or arbitration shall be brought to enforce or
interpret any provision of this Plan which relates to Human Genome’s obligation to make payments
hereunder, then Human Genome, to the extent permitted by applicable law and Human Genome’s Charter,
shall indemnify the Participant for his or her reasonable attorneys’ fees and disbursements
incurred in such proceedings, and shall pay pre-judgment interest on any money judgment obtained by
the Participant calculated at the prime rate of interest published from time to time by The Wall
Street Journal, northeast edition (“Prime Rate”) from the date that payment(s) to him or her should
have been made under this Plan.

     3.5.2. Payment Obligations; Overdue Payments. The Corporation’s obligations to make
the payments and provide the benefits to the Participant under this Plan shall be absolute and
unconditional and shall not be affected in any way by any circumstances, including, without
limitation, any offset, counterclaim, recoupment, defense or other right which Human Genome may
have against the Participant or anyone else, provided, however, that as a condition
to payment of amounts under this Plan, the Participant shall execute by no later than the scheduled
payment date a general release and waiver (the “Waiver”), in form and substance reasonably
satisfactory to Human Genome, of all claims relating to the Participant’s employment by the
Corporation and the termination of such employment, including, but not limited to, discrimination
claims, employment-related tort claims, contract claims and claims under this Plan (other than
claims with respect to benefits under the Corporation’s tax-qualified retirement plans,
continuation of coverage or benefits solely as required by Part 6 of Title I of the Employee
Retirement Income Security Act of 1974, or any obligation of Human Genome to provide future
performance under Section 3.2.3). All amounts payable by Human Genome hereunder shall be paid
without notice or demand, except as may be required with respect to the Waiver. Each and

- 8 -

 

every payment made hereunder by Human Genome shall be final. The Corporation shall not seek to recover
all or any part of such payment from the Participant or from whosoever may be entitled thereto, for
any reason whatsoever. The Participant shall not be obligated to seek other employment in
mitigation of the amounts payable or arrangements made under any provision of this Plan, and the
obtaining of any such other employment shall in no event effect any reduction of Human Genome’s
obligations to pay the Lump Sum Cash Payment. The Participant shall be entitled to receive
interest at the Prime Rate on any payments under this Plan that are overdue, provided,
however, that no payments shall be deemed to be overdue until the Participant executes the
Waiver and any rescission period with respect to such Waiver has expired or to the extent that
payments are delayed pursuant to the requirements of Section 409A of the Code.

     3.5.3. Confidential Information. The Participant shall at all times hold in a
fiduciary capacity for the benefit of the Corporation all secret, confidential or proprietary
information, knowledge or data relating to the Corporation, and its respective businesses, which
shall have been obtained by the Participant during the Participant’s employment by the Corporation
and which shall not be or become public knowledge (other than by acts by the Participant or
representatives of the Participant in violation of this Plan) including, but not limited to, the
following: (i) gene and protein sequences; (ii) biological data; (iii) clones and biologic
materials; (iv) laboratory, pre-clinical and clinical experiments and studies; (v) performance
characteristics of the Corporation’s products; (vi) marketing plans, business plans, strategies,
forecasts, budgets, projections and costs; (vii) gene sequencing techniques and reagents; (viii)
bioinformatics; (ix) personnel information; (x) customer, vendor and supplier lists; (xi) customer,
vendor and supplier needs, transaction histories, contacts, volumes, characteristics, agreements
and prices; (xii) promotions, operations, sales, marketing, and research and development; (xiii)
business operations, internal structures, and financial affairs; (xiv) systems and procedures; (xv)
pricing structure of the Corporation’s services and products; (xvi) proposed services and products;
(xvii) contracts with other parties; and (xviii) any other information that the Corporation is
obligated by law, rule or regulation to maintain as confidential (the “Confidential Information”).
During the Participant’s employment with the Corporation and after termination of such employment
at any time or for any reason, and regardless of whether any payments are made to the Participant
under this Plan as a result of such termination, the Participant shall not, without the prior
written consent of the Corporation or as may otherwise be required by law or legal process,
communicate or divulge any Confidential Information to any person other than the Corporation, its
employees and those designated by it or use any Confidential Information except for the benefit of
the Corporation. Immediately upon termination of the Participant’s employment with the
Corporation at any time or for any reason, the Participant shall return to the

- 9 -

 

Corporation all Confidential Information, including, but not limited to, any and all copies, reproductions, notes
or extracts of Confidential Information. “Confidential Information” shall not include (v)
Confidential Information which at the time of disclosure is already in the public domain; (w)
Confidential Information which the Participant can demonstrate by written evidence was in his
possession or known to him prior to his employment with the Corporation which is not subject to an
obligation of confidentiality to the Corporation; (x) Confidential Information which subsequently
becomes part of the public domain through no fault of the Participant; (y) Confidential Information
which becomes known to the Participant through a third party who is under no obligation of
confidentiality to the Corporation; and (z) Confidential Information which is required to be
disclosed by law or by judicial administrative proceedings. Upon service to the Participant, or
anyone acting on the Participant’s behalf, of any subpoena, court order, or other legal process
requiring the Participant to disclose information that would be Confidential Information but for
the preceding sentence, the Participant shall immediately provide written notice to the Corporation
of such service and of the content of any testimony or information to be disclosed.

     3.5.4. Solicitation of Employees. During the Participant’s employment with the
Corporation and for a period of twelve (12) months after termination of such employment at any time
and for any reason, and regardless of whether any payments are made to the Participant under this
Plan as a result of such termination, the Participant shall not solicit, participate in or promote
the solicitation of any person who was employed by the Corporation at the time of the Participant’s
termination of employment with the Corporation to leave the employ of the Corporation, or, on
behalf of himself or any other person, hire, employ or engage any such person. The Participant
further agrees that, during such time, if an employee of the Corporation contacts the Participant
about prospective employment, the Participant will inform such employee that he or she cannot
discuss the matter further without informing the Corporation.

     3.5.5. Application of Restrictions Respecting Confidential Information and Solicitation of
Employees. The requirements and obligations of the Participant under Sections 3.5.3 and 3.5.4
shall be in addition to, and not a limitation under, any other requirements and obligations of the
Participant, at law or otherwise. The term “person” for purposes of Sections 3.5.3 and 3.5.4 shall
include any individual or entity, including any corporation, trust or partnership.

     3.5.6. Successors. All right under this Plan are personal to the Participant and
without the prior written consent of Human Genome shall not be assignable by the Participant
otherwise than by will or the laws of descent and distribution. This Plan shall inure to the
benefit of and be

- 10 -

 

enforceable by the Participant’s legal representative. This Plan shall inure to
the benefit of and be binding upon Human Genome and its successors and assigns. Human Genome will
require any successor (whether direct or indirect, by purchase, merger, consolidation or otherwise)
to all or substantially all of the business and/or assets of Human Genome to assume expressly and
agree to perform this Plan in the same manner and to the same extent that Human Genome would be
required to perform it.

     3.5.7. Controlling Law; Jurisdiction. This Plan shall in all respects be governed by,
and construed in accordance with, the laws of the State of Maryland (without regard to the
principles of conflicts of laws). The Corporation and the Participants irrevocably consent and
submit to the jurisdiction of the Circuit Court for the county in the State of Maryland in which
the Corporation’s principal place of business is located, or in any Federal court sitting in the
State of Maryland, for the purposes of any controversy, claim, dispute or action arising out of or
related to this Plan, and hereby waive any defense of an inconvenient forum and any right of
jurisdiction on account of the parties’ place of residence or domicile.

     3.5.8. Severability. Any provision in this Plan which is prohibited or unenforceable
in any jurisdiction shall, as to such jurisdiction, be ineffective only to the extent of such
prohibition or unenforceability without invalidating or affecting the remaining provisions hereof,
and any such prohibition or unenforceability in any jurisdiction shall not invalidate or render
unenforceable such provision in any other jurisdiction.

     3.5.9 409A Compliance.

     (i) This Plan is intended to comply with, or otherwise be exempt from, Section 409A of the
Code and any regulations and Treasury guidance promulgated thereunder.

     (ii) The Corporation and Participant agree that they will execute any and all amendments to
this Plan as they mutually agree in good faith may be necessary to ensure compliance with the
provisions of Section 409A of the Code.

     (iii) The preceding provisions, however, shall not be construed as a guarantee by the
Corporation of any particular tax effect to Participant under this Plan. The Corporation shall not
be liable to Participant for any payment made under this Plan, at the direction or with the consent
of Participant, which is determined to result in an additional tax, penalty, or interest under
Section 409A of the Code, nor for reporting in good faith any payment made under this Plan as an
amount includible in gross income under Section 409A of the Code.

- 11 -

 

     (iv) For purposes of Section 409A of the Code, the right to a series of installment payments
under this Plan shall be treated as a right to a series of separate payments.

     (v) With respect to any reimbursement of expenses of, or any provision of in-kind benefits to,
Participant, as specified under this Plan, such reimbursement of expenses or provision of in-kind
benefits shall be subject to the following conditions: (1) the expenses eligible for reimbursement
or the amount of in-kind benefits provided in one taxable year shall not affect the expenses
eligible for reimbursement or the amount of in-kind benefits provided in any other taxable year,
except for any medical reimbursement arrangement providing for the reimbursement of expenses
referred to in Section 105(b) of the Code; (2) the reimbursement of an eligible expense shall be
made no later than the end of the year after the year in which such expense was incurred; and (3)
the right to reimbursement or in-kind benefits shall not be subject to liquidation or exchange for
another benefit.

     (vi) For purposes of Section 409A of the Code, the date as of which the Corporation and the
Participant reasonably anticipate that no further services would be performed by the Participant
shall be construed as the date that the Participant first incurs a “separation from service” as
defined under Section 409A of the Code.

     (vii) If a payment obligation under this Plan arises on account of Participant’s termination
of employment while he is a “specified employee” (as defined under Section 409A of the Code and
determined in good faith by the Compensation Committee), any payment of “deferred compensation” (as
defined under Treasury Regulation Section 1.409A-1(b)(1), after giving effect to the exemptions in
Treasury Regulation Sections 1.409A-1(b)(3) through (b)(12)) shall accrue at the Prime Rate of
interest and shall be made within 15 days after the end of the six-month period beginning on the
date of such termination of employment or, if earlier, within 15 days after appointment of the
personal representative or executor of Participant’s estate following his death.

Date: December 13, 2007

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EXHIBIT A

SECOND AMENDED AND RESTATED KEY EXECUTIVE SEVERANCE PLAN

[DATE]

               
                    

               
                    

               
                    

Dear                          :

     [For new Participants:]On
[                    ], 2007, the Corporation amended and restated the Amended and
Restated Key Executive Severance Plan (as amended and restated, the “Second Amended and Restated
KESP”), a copy of which is enclosed. You are eligible to participate in the Second Amended and
Restated KESP and will become a Participant therein upon signing this letter agreement. As used in
this letter agreement, each capitalized term, if not defined herein, has the meaning ascribed to it
under the Second Amended and Restated KESP.

     [For existing Participants:]You are currently a Participant in the Human Genome Sciences, Inc.
Amended and Restated Key Executive Severance Plan. On [                    ], 2007, the Corporation amended and
restated the Amended and Restated Key Executive Severance Plan (as amended and restated, the
“Second Amended and Restated KESP”), enclosed, in order to conform the Amended and Restated Key
Executive Severance Plan to changes made under the Internal Revenue Code of 1986, as amended, and
to incorporate other revisions to the Amended and Restated Key Executive Severance Plan that the
Compensation Committee of the Board of Directors determined to be desirable and in the best
interests of the Corporation. Your participation in the Second Amended and Restated KESP is
conditioned upon your signing this letter agreement, and your signing of this letter agreement will
signify your consent to the amendments made to the Amended and Restated KESP pursuant to Section
3.4.3 thereof. As used in this letter agreement, each capitalized term, if not defined herein, has
the meaning ascribed to it under the Second Amended and Restated KESP.

     For purposes of Section 3.2.2 of the Second Amended and Restated KESP, the amount of the Lump
Sum Cash Payment, in the event you become entitled to benefits under the Second Amended and
Restated KESP, will be equal to the product of [two (2)] [one and one-half (11/2)] and the sum of (i)
your actual annual rate of base salary as in effect immediately prior to either the date of your
separation from service with the Corporation, as determined under Section 3.2.1, or the Effective
Date, whichever is higher, and (ii) the average of your annual bonus payments under the
Corporation’s annual bonus plan for the last three (3) years ending before either the Effective
Date or the date of your separation from service with the Corporation, whichever is higher.

- 1 -

 

     If you will not have been eligible to participate in the annual bonus plan for all three (3)
years ending before either the Effective Date or the date of your separation from service, your
average annual bonus payment (with respect to the years ending before the Effective Date or the
date of separation from service, as applicable) shall be determined only for the years with respect
to which you shall have been eligible to participate. For purposes of the Second Amended and
Restated KESP, your base salary will include (i) your cash allowances reportable as wages in Form
W-2, and (ii) the dollar value of any compensation that would have been paid to you but was
deferred or excluded for Federal income tax purposes under a deferred compensation plan, program or
arrangement, including amounts deferred under the Corporation’s 401(k) retirement savings plan.

     For purposes of Section 3.2.3, the Coverage Period, in the event you become entitled to
benefits under the Second Amended and Restated KESP, will begin on the date immediately following
your separation from service with the Corporation and shall end on the date 18 months thereafter.

     Please review the provisions of the Second Amended and Restated KESP and its stated purposes
carefully, including particularly the terms and conditions stated in Sections 3.4 (Terms and
Conditions of Participation), 3.5.3 (Confidential Information), and 3.5.4 (Solicitation of
Employees), to which you will agree by executing this letter agreement. In order to be entitled to
the benefits and agree to your obligations provided in the Second Amended and Restated KESP, please
execute the enclosed copy of this letter and return it to James H. Davis, Executive Vice President,
General Counsel and Secretary of Human Genome, whereupon the Second Amended and Restated KESP and
this letter will become a legally binding agreement between you and Human Genome.

	 	 	 	 	 	 	 
	 	 	 	 	Very truly yours,
	 
	 	 	 	 	 	 
	 	 	 	 	HUMAN GENOME SCIENCES, INC.
	 
	 	 	 	 	 	 
	 

	 	 	 	By:	 	 
	 

	 	 	 	 	 	 
	 

	 	 	 	 	 	James H. Davis, Ph.D., J.D.
	 

	 	 	 	 	 	Executive Vice President, General
	 

	 	 	 	 	 	Counsel and Secretary
	 
	 	 	 	 	 	 
	I hereby confirm my agreement	 	 	 	 
	with the foregoing:	 	 	 	 
	 
	 	 	 	 	 	 
	 	 	 	 	 
	Date:
	 	 	 	 	 	 
	 

	 	 

	 	 	 	 

- 2 -

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