Document:

<PAGE>

                                                                   Exhibit 10.23

                               AMICUS THERAPEUTICS

                            2007 DIRECTOR OPTION PLAN

1.   PURPOSE

     This Plan is intended to promote the recruiting and retention of highly
qualified Eligible Directors, to strengthen the commonality of interest between
directors and stockholders by encouraging ownership of Common Stock of the
Company by Eligible Directors, and to provide additional incentives for Eligible
Directors to promote the success of the Company's business. The Plan is not
intended to be an incentive stock option plan within the meaning of Section 422
of the Code. None of the Options granted hereunder will be "incentive stock
options" within the meaning of Section 422 of the Code.

2.   DEFINITIONS

     As used in the Plan the following terms shall have the respective meanings
set out below, unless the context clearly requires otherwise:

     2.1. "Accelerate", "Accelerated", and "Acceleration", when used with
respect to an Option, means that as of the time of reference such Option will
become exercisable with respect to some or all of the shares of Common Stock for
which it was not then otherwise exercisable by its terms.

     2.2. "Acquiring Person" means, with respect to any Transaction or any
acquisition described in clause (ii) of the definition of Change of Control, the
surviving or acquiring person or entity in connection with such Transaction or
acquisition, as the case may be, provided that if such surviving or acquiring
person or entity is controlled, directly or indirectly, by any other person or
entity (an "Ultimate Parent Entity") that is not itself controlled by any entity
or person that is not a natural person, the term "Acquiring Person" shall mean
such Ultimate Parent Entity.

     2.3. "Affiliate" means, with respect to any person or entity, any other
person or entity controlling, controlled by or under common control with the
first person or entity.

     2.4. "Applicable Voting Control Percentage" means twenty percent (20%).

     2.5. "Beneficial Ownership" has the meaning ascribed to such term in Rule
13d-3, or any successor rule thereto, promulgated by the Securities and Exchange
Commission pursuant to the Exchange Act.

     2.6. "Board" means the Company's board of directors.

     2.7. "Change of Control" means (i) the closing of any Sale of the Company
Transaction or (ii) the direct or indirect acquisition, in a single transaction
or a series of related transactions, by any person or Group (other than the
Company or a Controlled Affiliate of the Company) of Beneficial Ownership of
previously outstanding shares of capital stock of the Company if (A) immediately
after such acquisition, such person or Group, together with their respective
Affiliates, shall own or hold shares of capital stock of the Company possessing
at least the Applicable Voting Control Percentage of the total voting power of
the outstanding capital

<PAGE>

                                      -2-

stock of the Company and (B) immediately prior to such acquisition, such person
or Group, together with their respective Affiliates, did not own or hold shares
of capital stock of the Company possessing at least the Applicable Voting
Control Percentage of the total voting power of the outstanding capital stock of
the Company. Notwithstanding anything expressed or implied in the foregoing
provisions of this definition to the contrary, any direct or indirect
acquisition referred to in clause (ii) above in this definition shall not be
treated as a Change of Control if, at any time prior to or after such direct or
indirect acquisition, a majority of the members of the Board of Directors of the
Company as constituted immediately prior to such direct or indirect acquisition
consent in writing to exclude such direct or indirect acquisition from the scope
of this definition.

     2.8. "Code" means the Internal Revenue Code of 1986, as amended from time
to time, or any successor statute thereto, and any regulations issued from time
to time thereunder.

     2.9. "Controlled Affiliate" means, with respect to any person or entity,
any other person or entity that is controlled by such person or entity.

     2.10. "Committee" means any committee of the Board delegated responsibility
by the Board for the administration of the Plan, as provided in Section 5 of the
Plan. For any period during which no such committee is in existence, "Committee"
shall mean the Board and all authority and responsibility assigned the Committee
under the Plan shall be exercised, if at all, by the Board.

     2.11. "Common Stock" means common stock, par value $0.01 per share, of the
Company.

     2.12. "Company" means Amicus Therapeutics, Inc., a corporation organized
under the laws of the State of Delaware.

     2.13. "Eligible Director" means a director of one or more of the Company
and its Subsidiaries who is not also an employee or officer of one or more of
the Company and its Subsidiaries.

     2.14. "Exchange Act" means the Securities Exchange Act of 1934, as amended.

     2.15. "Grant Date" means the date as of which an Option is granted, as
determined under Section 7.1.

     2.16. "Group" has the meaning ascribed to such term in Section 13(d)(3) of
the Exchange Act or any successor section thereto.

     2.17. "Holder" means, with respect to any Option, (a) the Optionee to whom
such Option shall have been initially granted under the Plan, or (b) any
transferee of such Option to whom such Option shall have been transferred in
accordance with the provisions set forth herein.

     2.18. "Market Value" means the value of a share of Common Stock on a
particular date determined by such methods or procedures as may be established
by the Committee. Unless otherwise determined by the Committee, the Market Value
of Common Stock as of any date is the closing price for the Common Stock as
reported on the Nasdaq Global Market (or on any other national securities
exchange on which the Common Stock is then listed) for that date or, if

<PAGE>

                                      -3-

no closing price is reported for that date, the closing price on the next
preceding date for which a closing price was reported.

     2.19. "Option" means an option granted under the Plan to purchase shares of
Common Stock.

     2.20. "Option Agreement" means an agreement between the Company and the
Holder of an Option, setting forth the terms and conditions of the Option.

     2.21. "Optionee" means an Eligible Director to whom an Option shall have
been granted under the Plan.

     2.22. "Plan" means this 2007 Director Option Plan of the Company, as
amended and in effect from time to time.

     2.23. "Sale of the Company Transaction" means any Transaction in which the
stockholders of the Company immediately prior to such Transaction, together with
any and all of such stockholders' Affiliates, do not own or hold, immediately
after consummation of such Transaction, shares of capital stock of the Acquiring
Person in connection with such Transaction possessing at least a majority of the
total voting power of the outstanding capital stock of such Acquiring Person.

     2.24. "Securities Act" means the Securities Act of 1933, as amended.

     2.25. "Transaction" means any merger or consolidation of the Company with
or into another person or entity or the sale or transfer of all or substantially
all of the assets of the Company, in each case in a single transaction or in a
series of related transactions.

3.   TERM OF THE PLAN

     Unless the Plan shall have been earlier terminated by the Board, Options
may be granted under this Plan at any time in the period commencing upon the
effectiveness of the Plan in accordance with the provisions of Section 17 hereof
and ending immediately prior to the tenth anniversary of the adoption of the
Plan by the Board. Options granted pursuant to the Plan within such period shall
not expire solely by reason of the termination of the Plan.

4.   STOCK SUBJECT TO THE PLAN

     Subject to the provisions of Section 8 of the Plan, at no time shall the
number of shares of Common Stock issued pursuant to or subject to outstanding
Options granted under the Plan exceed the sum of (a) two hundred thousand
(200,000) shares of Common Stock plus (b) an annual increase to be added,
automatically and without further action, on January 1 of each calendar year
equal to the lesser of (i) sixty six thousand six hundred sixty seven (66,667)
shares of Common Stock and (ii) one fourth of one percent (0.25%) of the
Company's outstanding equity on a fully diluted basis (calculated by treating
all outstanding warrants, stock options and convertible securities of the
Company, whether or not then vested or exercisable, as if they had been
exercised for or converted into the full number of shares of capital stock of
the Company subject to such outstanding warrants, stock options and convertible
securities), on the December 31 that immediately precedes such January 1;
provided, however, that the Board may, at any time and on any one or more
occasions, take action to waive the annual increase set forth in clause (b), in
whole or in part. For purposes of applying the foregoing

<PAGE>

                                      -4-

limitation, (a) if any Option expires, terminates, or is cancelled for any
reason without having been exercised in full, the shares not purchased by the
Optionee (or the Holder of such Option) shall again be available for Options
thereafter to be granted under the Plan, and (b) if any Option is exercised by
delivering previously owned shares in payment of the exercise price therefor,
only the net number of shares, that is, the number of shares issued minus the
number received by the Company in payment of the exercise price, shall be
considered to have been issued pursuant to an Option granted under the Plan.
Shares of Common Stock issued pursuant to the Plan may be either authorized but
unissued shares or shares held by the Company in its treasury.

5.   ADMINISTRATION

     The Plan shall be administered by the Committee; provided, however, that at
any time and on any one or more occasions the Board may itself exercise any of
the powers and responsibilities assigned the Committee under the Plan and when
so acting shall have the benefit of all of the provisions of the Plan pertaining
to the Committee's exercise of its authorities hereunder. Subject to the
provisions of the Plan, the Committee shall have complete authority to interpret
the Plan, to prescribe, amend and rescind rules and regulations relating to it,
to determine the terms and provisions of the respective Option Agreements (which
need not be identical), and to make all other determinations necessary or
advisable for the administration of the Plan. The Committee's determinations
made in good faith on matters referred to in this Plan shall be final, binding
and conclusive on all persons having or claiming any interest under the Plan or
an Option made pursuant hereto.

6.   AUTHORIZATION AND ELIGIBILITY

     Only Eligible Directors shall be granted Options under the Plan. Each grant
of an Option shall be subject to all applicable terms and conditions of the Plan
(including but not limited to any specific terms and conditions set forth in
Section 7 below), and such other terms and conditions, not inconsistent with the
terms of the Plan, as the Committee may prescribe. No prospective holder of an
Option shall have any rights with respect to such Option, unless and until such
holder has executed an agreement evidencing the Option, delivered a fully
executed copy thereof to the Company, and otherwise complied with the applicable
terms and conditions of such Option.

7.   SPECIFIC TERMS OF OPTIONS

     7.1. Annual Grants. Subject to the Plan's effectiveness as set forth in
Section 17 and to the provisions set forth below in this Section 7.1, on the
date of each annual meeting of stockholders of the Company, commencing with the
2008 annual meeting of stockholders, each Eligible Director who continues to be
a director of the Company as of the close of business on the date of such annual
meeting of stockholders shall be granted an Option as of the close of business
on such date, to purchase Ten Thousand (10,000) shares of Common Stock (subject
to adjustment as set forth in Section 8) or such other greater or smaller number
of shares of Common Stock as the Board shall have set by resolution of the Board
prior to the date of such annual meeting of stockholders (unless such resolution
shall provide that such Eligible Director shall not receive an Option under this
Section 7.1 at such annual meeting of stockholders, in which case such Eligible
Director shall not be granted any Option under this Section 7.1 as of the close
of business on the date of such annual meeting). Subject to the provisions of
this Section 7.1 or Section 9 hereof, grants of

<PAGE>

                                      -5-

Options under this Section 7.1 shall occur automatically without any action
being required of the Optionee, the Committee, the Board, the Company or any
other person, entity or body.

     7.2. Certain Terms of Option; Exercise Price. Each Option granted to an
Optionee under this Section 7 shall have an exercise price equal to 100% of the
Market Value of the Stock on the applicable Grant Date. No Option granted
pursuant to this Plan is intended to qualify as an incentive stock option within
the meaning of Section 422 of the Code. The grants shall be evidenced by Option
Agreements containing provisions that are in all respects consistent with this
Section 7. All of such Option Agreements shall contain identical terms and
conditions, except as otherwise required or permitted by this Section 7.

     7.3. Option Period. The option period for each Option granted pursuant to
the Plan shall be ten (10) years from the Grant Date of such Option.

     7.4. Exercisability. Subject to Section 7.5 below, each Option granted to
an Eligible Director pursuant to Section 7.1 above shall automatically become
exercisable for 100% of the shares of Common Stock subject to such Option on the
date of the annual meeting of stockholders of the Company in the calendar year
following the calendar year during which such Option was automatically granted.
In the case of an Option not otherwise immediately exercisable in full, the
Committee may Accelerate such Option in whole or in part at any time.

     7.5. Effect of Termination of Board Member Relationship. Unless the
Committee at any time shall provide otherwise with respect to any Option, if an
Optionee ceases to be a director of the Company and its Affiliates for any
reason or no reason (whether voluntarily or involuntarily, including as a result
of death), any outstanding Option initially granted to such Optionee, whether
then held by such Optionee or any other Holder, shall cease to be exercisable in
any respect not later than ninety (90) days following that event and, for the
period it remains exercisable following that event, shall be exercisable only to
the extent exercisable at the date of that event.

     7.6. Transferability. Except as otherwise provided in this Section 7.6,
Options shall not be transferable, and no Option or interest therein may be
sold, transferred, pledged, assigned, or otherwise alienated or hypothecated,
other than by will or by the laws of descent and distribution (subject always to
the provisions of Section 7.5 hereof). Except as otherwise provided in this
Section 7.6, all of a Holder's rights in any Option may be exercised only during
the life of such Holder and only by such Holder or such Holder's legal
representative. However, the applicable Option Agreement or the Committee (at or
after the grant of an Option) may provide that an Option may be transferred by
the applicable Holder to a family member; provided, however, that any such
transfer is without payment of any consideration whatsoever and that no transfer
of an Option shall be valid unless first approved by the Committee, acting in
its sole discretion, unless such transfer is permitted under the applicable
Option Agreement. For this purpose, "family member" means any child, stepchild,
grandchild, parent, stepparent, spouse, former spouse,

<PAGE>

                                      -6-

sibling, niece, nephew, mother-in-law, father-in-law, son-in-law,
daughter-in-law, brother-in-law, or sister-in-law, including adoptive
relationships, any person sharing the applicable Holder's household (other than
a tenant or employee), a trust in which the foregoing persons and/or the
applicable Holder have more than fifty percent (50%) of the beneficial
interests, a foundation in which the foregoing persons and/or the applicable
Holder control the management of assets, and any other entity in which these
persons and/or the applicable Holder own more than fifty percent (50%) of the
voting interests. The Committee may at any time or from time to time delegate to
one or more officers of the Company the authority to permit transfers of Options
to third parties pursuant to this Section 7.6, which authorization shall be
exercised by such officer or officers in accordance with guidelines established
by the Committee at any time and from time to time. The restrictions on
transferability set forth in this Section 7.6, shall in no way preclude any
Holder from effecting "cashless" exercises of an Option pursuant to the terms of
the Plan.

     7.7. Method of Exercise. An Option may be exercised by the Holder of such
Option by giving written notice, in the manner provided in Section 15,
specifying the number of shares of Common Stock with respect to which the Option
is then being exercised. The notice shall be accompanied by payment in the form
of cash or check payable to the order of the Company in an amount equal to the
exercise price of the shares of Common Stock to be purchased or, subject in each
instance to the Committee's approval, acting in its sole discretion and subject
to such conditions, if any, as the Committee may deem necessary to comply with
applicable laws, rules and regulations and to avoid adverse accounting effects
to the Company, by delivery to the Company of shares of Common Stock having a
Market Value equal to the exercise price of the shares to be purchased. No
Holder shall be permitted to effect payment of any amount of the exercise price
of the shares of Common Stock to be purchased by executing and delivering to the
Company a promissory note. If the Common Stock is traded on an established
market, payment of any exercise price may also be made through and under the
terms and conditions of any formal cashless exercise program authorized by the
Company entailing the sale of the Common Stock subject to any Option in a
brokered transaction (other than to the Company). Receipt by the Company of such
notice and payment in any authorized or combination of authorized means shall
constitute the exercise of the Option. Within thirty (30) days thereafter but
subject to the remaining provisions of the Plan, the Company shall deliver or
cause to be delivered to the Holder or his agent a certificate or certificates
for the number of shares then being purchased. Such shares shall be fully paid
and nonassessable. Notwithstanding any of the foregoing provisions in this
subsection 7.7 to the contrary, (A) no Option shall be considered to have been
exercised unless and until all of the provisions governing such exercise
specified in the Plan and in the relevant Option Agreement shall have been duly
complied with; and (B) the obligation of the Company to issue any shares upon
exercise of an Option is subject to the provisions of Section 9.1 hereof and to
compliance by the Holder with all of the provisions of the Plan and the relevant
Option Agreement.

     7.8. Rights Pending Exercise. No person holding an Option shall be deemed
for any purpose to be a stockholder of the Company with respect to any of the
shares of Common Stock issuable pursuant to his Option, except to the extent
that the Option shall have been exercised with respect thereto and, in addition,
a certificate shall have been issued therefor and delivered to such holder or
his agent.

     7.9 Grants to Optionee's Outside the United States. The Committee may
modify the terms of any Option under the Plan granted to an Optionee who is, at
the time of grant or during the term of the Option, resident or primarily
employed outside of the United States in any manner deemed by the Committee to
be necessary or appropriate in order that such Option shall conform

<PAGE>

                                      -7-

to laws, regulations, and customs of the country in which such Optionee is then
resident or primarily employed, or so that the value and other benefits of the
Option to such Optionee, as affected by foreign tax laws and other restrictions
applicable as a result of such Optionee's residence or employment abroad, shall
be comparable to the value of such Option to an Optionee who is resident or
primarily employed in the United States. An Option may be modified under this
Section 7.9 in a manner that is inconsistent with the express terms of the
Plan, so long as such modifications will not contravene any applicable law or
regulation. The Committee may establish supplements to, or amendments,
restatements, or alternative versions of the Plan for the purpose of granting
and administrating any such modified Option. No such modification, supplement,
amendment, restatement or alternative version may increase the share limit of
Section 4.

8.   ADJUSTMENT PROVISIONS

     8.1. Adjustment for Corporate Actions. All of the share numbers set forth
in the Plan reflect the capital structure of the Company immediately after the
closing of the initial public offering of the Company's Common Stock. Subject to
the provisions of Section 8.2, if subsequent to such closing the outstanding
shares of Common Stock (or any other securities covered by the Plan by reason of
the prior application of this Section) are increased, decreased, or exchanged
for a different number or kind of shares or other securities, or if additional
shares or new or different shares or other securities are distributed with
respect to such shares of Common Stock or other securities, through merger,
consolidation, sale of all or substantially all the property of the Company,
reorganization, recapitalization, reclassification, stock dividend, stock split,
reverse stock split, or other distribution with respect to such shares of Common
Stock, or other securities, an appropriate and proportionate adjustment will be
made in (i) the maximum numbers and kinds of shares provided in Section 4, (ii)
the numbers and kinds of shares or other securities subject to the then
outstanding Options, and (iii) the exercise price for each share or other unit
of any other securities subject to then outstanding Options (without change in
the aggregate purchase price as to which such Options remain exercisable).

     8.2. Change of Control. Subject to the applicable provisions of the Option
Agreement, in the event of a Change of Control, the Committee shall have the
discretion, exercisable in advance of, at the time of, or (except to the extent
otherwise provided below) at any time after, the Change of Control, to provide
for any or all of the following (subject to and upon such terms as the Committee
may deem appropriate): (A) the assumption of outstanding Options, or the
substitution of outstanding Options with equivalent options, by the acquiring or
succeeding corporation or entity (or an affiliate thereof); or (B) the
termination of all Options (other than Options that are assumed or substituted
pursuant to clause (A) above) that remain outstanding at the time of the
consummation of the Change of Control, provided that, the Committee shall have
made the determination to effect such termination prior to the consummation of
the Change of Control and the Committee shall have given, or caused to be given,
to all Optionees written notice of such potential termination at least five
business days prior to the consummation of the Change of Control, and provided,
further, that, if the Committee shall have determined in its sole and absolute
discretion that the Corporation make payment or provide consideration to the
holders of such terminated Options on account of such termination, which payment
or consideration shall be on such terms and conditions as the Committee shall
have determined (and which could consist of, in the Committee's sole and
absolute discretion, payment to the applicable Optionee or Optionees of an
amount of cash equal to the difference between the Market Value of the shares of
Common Stock for which the Option is then exercisable and the aggregate exercise
price for such shares under the Option), then the Corporation shall be required
to make, or cause to be made, such payment or provide, or cause to be provided,

<PAGE>

                                      -8-

such consideration in accordance with the terms and conditions so determined by
the Committee; otherwise the Corporation shall not be required to make any
payment or provide any consideration in connection with, or as a result of, the
termination of Options pursuant to the foregoing provisions of this clause (B).
Upon the occurrence of a Change of Control, any and all Options not already
exercisable in full shall Accelerate with respect to all of the shares of Common
Stock for which such Options are not then exercisable. In the case of any Option
that would be terminated pursuant to clause (B) above of this Section 8.2 upon
consummation of a Change of Control, such Option, to the extent not already
exercisable in full on the date the Holder thereof is given written notice of
such potential termination as required by the foregoing provisions of this
Section 8.2, shall, on the date such written notice of termination is given or
required to be given, Accelerate with respect to all of the shares of Common
Stock for which such Option is not then exercisable; provided, however, that if
such Change of Control is not and will not be consummated then the Acceleration
of such Option pursuant to the provisions of this sentence, but only if and to
the extent that such Option remains outstanding at the time written notice is
given to the Holder thereof that such Change of Control has not and will not be
consummated, shall be automatically revoked and such Option shall thereafter
continue to be exercisable in accordance with its terms as if the Acceleration
thereof pursuant to this sentence had never occurred. The provisions of this
Section 8.2 shall not be construed as to limit or restrict in any way the
Committee's general authority under Sections 7.4 hereof to Accelerate Options in
whole or in part at any time. Each outstanding Option that is assumed in
connection with a Change of Control, or is otherwise to continue in effect
subsequent to a Change of Control, will be appropriately adjusted, immediately
after the Change of Control, as to the number and class of securities and the
price at which it may be exercised in accordance with Section 8.1.

     8.3. Dissolution or Liquidation. Upon dissolution or liquidation of the
Company, each outstanding Option shall terminate, but the Optionee (if at the
time he or she is a board member of the Company or any of its Affiliates) shall
have the right, immediately prior to such dissolution or liquidation, to
exercise the Option to the extent exercisable on the date of such dissolution or
liquidation.

     8.4. Related Matters. Any adjustment in Options made pursuant to this
Section 8 shall be determined and made, if at all, by the Committee and shall
include any correlative modification of terms, including exercise prices, rates
of vesting or exercisability which the Committee may deem necessary or
appropriate so as to ensure that the rights of the Holders in their respective
Options are not substantially diminished nor enlarged as a result of the
adjustment and corporate action other than as expressly contemplated in this
Section 8. No fraction of a share shall be purchasable or deliverable upon
exercise, but in the event any adjustment hereunder of the number of shares
covered by an Option shall cause such number to include a fraction of a share,
such number of shares shall be adjusted to the nearest smaller whole number of
shares. No adjustment of an Option exercise price per share pursuant to this
Section 8 shall result in an exercise price which is less than the par value of
the Common Stock.

9.   SETTLEMENT OF OPTIONS

     9.1. Violation of Law. Notwithstanding any other provision of the Plan or
the relevant Option Agreement, if, at any time, in the reasonable opinion of the
Company, the issuance of shares of Common Stock covered by an Option may
constitute a violation of law, then the Company may delay such issuance and the
delivery of a certificate for such shares until (i) approval shall have been
obtained from such governmental agencies, other than the Securities and Exchange
Commission, as may be required under any applicable law, rule, or regulation and

<PAGE>

                                      -9-

(ii) in the case where such issuance would constitute a violation of a law
administered by or a regulation of the Securities and Exchange Commission, one
of the following conditions shall have been satisfied:

          (a) the shares are at the time of the issue of such shares effectively
registered under the Securities Act; or

          (b) the Company shall have determined, on such basis as it deems
appropriate (including an opinion of counsel in form and substance satisfactory
to the Company) that the sale, transfer, assignment, pledge, encumbrance or
other disposition of such shares or such beneficial interest, as the case may
be, does not require registration under the Securities Act or any applicable
state securities laws.

     9.2. Corporate Restrictions on Rights in Stock. Any Common Stock to be
issued pursuant to Options granted under the Plan shall be subject to all
restrictions upon the transfer thereof which may be now or hereafter imposed by
the Certificate of Incorporation and the By-laws of the Company, each as amended
and in effect from time to time. Whenever Common Stock is to be issued pursuant
to an Option, if the Committee so directs at the time of grant (or, if such
Option is an Option, at any time prior to the exercise thereof), the Company
shall be under no obligation, notwithstanding any other provision of the Plan or
the relevant Option Agreement to the contrary, to issue such shares until such
time, if ever, as the recipient of the Option (and any person who exercises any
Option, in whole or in part), shall have become a party to and bound by any
agreement that the Committee shall require in its sole discretion. In addition,
any Common Stock to be issued pursuant to Options granted under the Plan shall
be subject to all stop-transfer orders and other restrictions as the Committee
may deem advisable under the rules, regulations and other requirements of any
stock exchange upon which the Common Stock is then listed, and any applicable
federal or state securities laws, and the Committee may cause a legend or
legends to be put on any such certificates to make appropriate reference to such
restrictions.

     9.3. Investment Representations. The Company shall be under no obligation
to issue any shares covered by an Option unless the shares to be issued pursuant
to Options granted under the Plan have been effectively registered under the
Securities Act or the Holder shall have made such written representations to the
Company (upon which the Company believes it may reasonably rely) as the Company
may deem necessary or appropriate for purposes of confirming that the issuance
of such shares will be exempt from the registration requirements of that Act and
any applicable state securities laws and otherwise in compliance with all
applicable laws, rules and regulations, including but not limited to that the
Holder is acquiring shares for his or her own account for the purpose of
investment and not with a view to, or for sale in connection with, the
distribution of any such shares.

     9.4. Registration. If the Company shall deem it necessary or desirable to
register under the Securities Act or other applicable statutes any shares of
Common Stock issued or to be issued pursuant to Options granted under the Plan,
or to qualify any such shares of Common Stock for exemption from the Securities
Act or other applicable statutes, then the Company shall take such action at its
own expense. The Company may require from each recipient of an Option, or each
holder of shares of Common Stock acquired pursuant to the Plan, such information
in writing for use in any registration statement, prospectus, preliminary
prospectus or offering circular as is reasonably necessary for such purpose and
may require reasonable indemnity to the Company and its officers and directors
from such holder against all losses, claims, damage and liabilities arising from
such use of the information so furnished and caused by any untrue

<PAGE>

                                      -10-

statement of any material fact therein or caused by the omission to state a
material fact required to be stated therein or necessary to make the statements
therein not misleading in the light of the circumstances under which they were
made.

     9.5. Lock-Up. Without the prior written consent of the Company or the
managing underwriter in any public offering of shares of Common Stock, no Holder
shall sell, make any short sale of, loan, grant any option for the purchase of,
pledge or otherwise encumber, or otherwise dispose of, any shares of Common
Stock during the one hundred-eighty (180) day period commencing on the effective
date of the registration statement relating to any underwritten public offering
of securities of the Company. The foregoing restrictions are intended and shall
be construed so as to preclude any Holder from engaging in any hedging or other
transaction that is designed to or reasonably could be expected to lead to or
result in, a sale or disposition of any shares of Common Stock during such
period even if such shares of Common Stock are or would be disposed of by
someone other than such Holder. Such prohibited hedging or other transactions
would include, without limitation, any short sale (whether or not against the
box) or any purchase, sale or grant of any right (including without limitation
any put or call option) with respect to any shares of Common Stock or with
respect to any security that includes, relates to, or derives any significant
part of its value from any shares of Common Stock. Without limiting the
generality and applicability of the foregoing provisions of this Section 9.5,
if, in connection with any underwritten public offering of securities of the
Company, the managing underwriter of such offering requires that the Company's
directors and officers enter into a lock-up agreement, then (a) each Holder
(regardless of whether or not such Holder has complied or complies with the
provisions of clause (b) below) shall be bound by, and shall be deemed to have
agreed to, the same lock-up terms as those to which the Company's directors and
officers are required to adhere; and (b) at the request of the Company or such
managing underwriter, each Holders shall execute and deliver a lock-up agreement
in form and substance equivalent to that which is required to be executed by the
Company's directors and officers.

     9.6. Placement of Legends; Stop Orders; Etc. Each share of Common Stock to
be issued pursuant to Options granted under the Plan may bear a reference to the
investment representations made in accordance with Section 9.3 in addition to
any other applicable restrictions under the Plan, the terms of the Option and,
if applicable, under any agreement between the Company and the Optionee and/or
Holder, and to the fact that no registration statement has been filed with the
Securities and Exchange Commission in respect to such shares of Common Stock.
All certificates for shares of Common Stock or other securities delivered under
the Plan shall be subject to such stock transfer orders and other restrictions
as the Committee may deem advisable under the rules, regulations, and other
requirements of any stock exchange upon which the Common Stock is then listed,
and any applicable federal or state securities law, and the Committee may cause
a legend or legends to be placed on any such certificates to make appropriate
reference to such restrictions.

     9.7. Tax Withholding. Whenever shares of Common Stock are issued or to be
issued pursuant to Options granted under the Plan, the Company shall have the
right to require the recipient to remit to the Company an amount sufficient to
satisfy federal, state, local or other withholding tax requirements if, when,
and to the extent required by law (whether so required to secure for the Company
an otherwise available tax deduction or otherwise) prior to the delivery of any
certificate or certificates for such shares. The obligations of the Company
under the Plan shall be conditional on satisfaction of all such withholding
obligations and the Company shall, to the extent permitted by law, have the
right to deduct any such taxes from any payment of any kind otherwise due to the
recipient of an Option. However, in such cases Holders may elect,

<PAGE>

                                      -11-

subject to the approval of the Committee, acting in its sole discretion, to
satisfy an applicable withholding requirement, in whole or in part, by having
the Company withhold shares to satisfy their tax obligations. Holders may only
elect to have shares of Common Stock withheld having a Market Value on the date
the tax is to be determined equal to the minimum statutory total tax which could
be imposed on the transaction. All elections shall be irrevocable, made in
writing, signed by the Holder, and shall be subject to any restrictions or
limitations that the Committee deems appropriate.

10.  RESERVATION OF STOCK

     The Company shall at all times during the term of the Plan and any
outstanding Options granted hereunder reserve or otherwise keep available such
number of shares of Common Stock as will be sufficient to satisfy the
requirements of the Plan (if then in effect) and such Options and shall pay all
fees and expenses necessarily incurred by the Company in connection therewith.

11.  NO SPECIAL SERVICE RIGHTS

     Nothing contained in the Plan or in any Option Agreement shall confer upon
any recipient of an Option any right with respect to any consulting or Board
member relationship or other association with the Company (or any Affiliate), or
interfere in any way with the right of the Company (or any Affiliate), subject
to the terms of any separate agreement or provision of law or corporate articles
or by-laws to the contrary, at any time to terminate Board member or to increase
or decrease, or otherwise adjust, the other terms and conditions of the
recipient's Board member relationship or other association with the Company and
its Affiliates.

12.  NONEXCLUSIVITY OF THE PLAN

     Neither the adoption of the Plan by the Board nor the submission of the
Plan to the stockholders of the Company shall be construed as creating any
limitations on the power of the Board to adopt such other incentive arrangements
as it may deem desirable, including without limitation, the granting of stock
options and restricted stock other than under the Plan, and such arrangements
may be either applicable generally or only in specific cases.

13.  TERMINATION AND AMENDMENT OF THE PLAN

     The Board may at any time terminate the Plan or make such amendments or
modifications of the Plan as it shall deem advisable. In the event of the
termination of the Plan, the terms of the Plan shall survive any such
termination with respect to any Option that is outstanding on the date of such
termination, unless the holder of such Option agrees in writing to terminate
such Option or to terminate all or any of the provisions of the Plan that apply
to such Option. Unless the Board otherwise expressly provides, any amendment or
modification of the Plan shall affect the terms of any Option outstanding on the
date of such amendment or modification as well as the terms of any Option made
prior to, or from and after, the date of such amendment or modification;
provided, however, that, except to the extent otherwise provided in the last
sentence of this paragraph, (i) no amendment or modification of the Plan shall
apply to any Option that is outstanding on the date of such amendment or
modification if such amendment or modification would reduce the number of shares
subject to such Option, increase the purchase price applicable to shares subject
to such Option or materially adversely affect the provisions applicable to such
Option that relate to the vesting or exercisability of such Option or of the
shares subject to such Option, and (ii) no amendment or modification of the Plan
shall apply to

<PAGE>

                                      -12-

any Option that is outstanding on the date of such amendment or modification
unless such amendment or modification of the Plan shall also apply to all other
Options outstanding on the date of such amendment or modification. In the event
of any amendment or modification of the Plan that is described in clause (i) or
(ii) of the foregoing proviso, such amendment or modification of the Plan shall
apply to any Option outstanding on the date of such amendment or modification
only if the recipient of such Option consents in writing thereto.

     The Committee may amend or modify, prospectively or retroactively, the
terms of any outstanding Option without amending or modifying the terms of the
Plan itself, provided that as amended or modified such Option is consistent with
the terms of the Plan as in effect at the time of the amendment or modification
of such Option, but no such amendment or modification of such Option shall,
without the written consent of the recipient of such Option, reduce the number
of shares subject to such Option, increase the purchase price applicable to
shares subject to such Option, adversely affect the provisions applicable to
such Option that relate to the vesting or exercisability of such Option or of
the shares subject to such Option, or otherwise materially adversely affect the
terms of such Option (except for amendments or modifications to the terms of
such Option or of the stock subject to such Option that are expressly permitted
by the terms of the Plan or that result from any amendment or modification of
the Plan in accordance with the provisions of the first paragraph of this
Section 13). The Committee is expressly authorized to amend any or all
outstanding Options to effect a repricing thereof by lowering the purchase price
applicable to the shares of Common Stock subject to such Option or Options
without the approval of the stockholders of the Company or the Holder or Holders
of such Option or Options, and, notwithstanding any of the foregoing provisions
of this paragraph to the contrary, in connection with such repricing to amend or
modify any of the other terms of the Option or Options so repriced, including,
without limitation, for purposes of reducing the number of shares subject to
such Option or Options or for purposes of adversely affecting the provisions
applicable to such Option or Options that relate to the vesting or
exercisability thereof, in each case without the approval of stockholders of the
Company or the Holder or Holders of such Option or Options.

     In addition, notwithstanding anything express or implied in any of the
foregoing provisions of this Section 13 to the contrary, the Committee may amend
or modify, prospectively or retroactively, the terms of any outstanding Option
to the extent the Committee reasonably determines necessary or appropriate to
conform such Option to the requirements of Section 409A of the Code (concerning
non-qualified deferred compensation), if applicable.

14.  INTERPRETATION OF THE PLAN

     In the event of any conflict between the provisions of this Plan and the
provisions of any applicable Option Agreement, the provisions of this Plan shall
control, except if and to the extent that the conflicting provision in such
Option Agreement was authorized and approved by the Committee at the time of the
grant of the Option evidenced by such Option Agreement or is ratified by the
Committee at any time subsequent to the grant of such Option, in which case the
conflicting provision in such Option Agreement shall control. Without limiting
the generality of the foregoing provisions of this Section 14, insofar as
possible the provisions of the Plan and such Option Agreement shall be construed
so as to give full force and effect to all such provisions. In the event of any
conflict between the provisions of this Plan and the provisions of any other
agreement between the Company and the Holder, the provisions of such agreement
shall control, but insofar as possible the provisions of the Plan and any such
agreement shall be construed so as to give full force and effect to all such
provisions.

<PAGE>

                                      -13-

15.  NOTICES AND OTHER COMMUNICATIONS

     Any notice, demand, request or other communication hereunder to any party
shall be deemed to be sufficient if contained in a written instrument delivered
in person or duly sent by first class registered, certified or overnight mail,
postage prepaid, or telecopied with a confirmation copy by regular, certified or
overnight mail, addressed or telecopied, as the case may be, (i) if to the
recipient of an Option, at his or her residence address last filed with the
Company and (ii) if to the Company, at its principal place of business,
addressed to the attention of its Chief Executive Officer, or to such other
address or telecopier number, as the case may be, as the addressee may have
designated by notice to the addressor. All such notices, requests, demands and
other communications shall be deemed to have been received: (i) in the case of
personal delivery, on the date of such delivery; (ii) in the case of mailing,
when received by the addressee; and (iii) in the case of facsimile transmission,
when confirmed by facsimile machine report.

16.  GOVERNING LAW

     The Plan and all Option Agreements and actions taken thereunder shall be
governed, interpreted and enforced in accordance with the laws of the State of
New Jersey, without regard to the conflict of laws principles thereof.

17.  EFFECTIVENESS OF PLAN

     This 2007 Director Option Plan was approved in May 2007 by the Board and by
the stockholders of the Company, and shall take effect only upon the
consummation of the Company's initial public offering of its Common Stock.
<PAGE>

                            AMICUS THERAPEUTICS, INC.

                      NON-STATUTORY STOCK OPTION AGREEMENT
                  (Form of Non-Statutory Stock Option Agreement
                    for Annual Automatic Grants to Directors)

         This NON-STATUTORY STOCK OPTION AGREEMENT, dated as of [date] (this
"Agreement"), is between AMICUS THERAPEUTICS, INC., a Delaware corporation (the
"Company"), and [Optionee Name] (the "Optionee"). Capitalized terms used herein
without definition shall have the meaning ascribed to such terms in the
Company's 2007 Director Option Plan, a copy of which is attached hereto as
Exhibit A (as amended, the "Plan").

         1. Grant of Option. Pursuant to the Plan, the Company automatically
grants to the Optionee an option (the "Option") to purchase from the Company all
or any number of an aggregate of [10,000] shares, subject to adjustment pursuant
to Section 8 of the Plan (the "Option Shares"), of the Company's common stock,
$.01 par value per share, at a price of $(price) per share. The Option is
automatically granted as of [Date of Grant] (the "Grant Date").

         2. Character of Option. The Option is not intended to be treated as an
"incentive stock option" within the meaning of Section 422 of the Internal
Revenue Code of 1986, as amended.

         3. Duration of Option. Unless subject to earlier expiration or
termination pursuant to the terms of the Plan or pursuant to Section 5 below,
the Option shall expire on the ten year anniversary of the Grant Date.

         4. Exercise of Option. The Option may be exercised, at any time and
from time to time until its expiration or termination, for any or all of those
Option Shares in respect of which the Option shall have become exercisable, in
accordance with the provisions set forth below in this Section 4 and in the
manner provided for in the Plan. Subject to the provisions of the Plan
(including, without limitation, the provisions of Section 7.4 of the Plan), the
Option shall become exercisable for 100% of the Option Shares on the date of the
annual meeting of the stockholders of the Company in the calendar year following
the calendar year of the Grant Date . Notwithstanding anything expressed or
implied to the contrary in the foregoing provisions of this Section 4(a), (A)
the exercisability of the Option shall, as provided in Section 8.2 of the Plan,
be automatically Accelerated under certain circumstances specified in Section
8,2 of the Plan, including, without limitation, upon the occurrence of a Change
of Control and (B) the exercisability of the Option may, as provided in Section
7.4 of the Plan, at any time be Accelerated in the discretion of the Committee.

         5. Effect of Termination of Board Member Relationship. Subject to
Section 7.5 of the Plan, if the Optionee ceases to be a director of the Company,
for any reason or no reason, then the Option shall cease to be exercisable in
any respect not later than ninety (90) days following that event and, for the
period it remains exercisable following that event, shall be exercisable only to
the extent exercisable at the date of that event (after giving effect to any
Acceleration that may be applicable to the Option).
<PAGE>

         6. Transfer of Option. Other than as expressly permitted by the
provisions of Section 7.6 of the Plan, the Option may not be transferred except
by will or the laws of descent and distribution and, during the lifetime of the
Optionee, may be exercised only by the Optionee.

         7. Incorporation of Plan Terms. The Option is granted subject to all of
the applicable terms and provisions of the Plan, including, but not limited to,
the limitations on the Company's obligation to deliver Option Shares upon
exercise set forth in Section 9.1 (Violation of Law), Section 9.2 (Corporate
Restrictions on Rights in Stock), Section 9.3 (Investment Representations) and
Section 9.7 (Tax Withholding).

         8. Miscellaneous. This Agreement shall be construed and enforced in
accordance with the internal, substantive laws of The State of New Jersey, and
shall be binding upon and inure to the benefit of any successor or assign of the
Company and any executor, administrator, trustee, guardian, or other legal
representative of the Optionee.

            [The remainder of this page is intentionally left blank.]
<PAGE>

         IN WITNESS WHEREOF, the parties have executed this Non-Statutory Stock
Option Agreement as a sealed instrument as of the date first above written.

AMICUS THERAPEUTICS, INC.                          OPTIONEE

By:                                                _____________________________
    ___________________________
    Name:
    Title

                                                   Optionee's Address:

                                                   -----------------------------

                                                   -----------------------------

                                                   -----------------------------

                                                   -----------------------------
<PAGE>

                                                                       Exhibit A

                            2007 DIRECTOR OPTION PLAN<PAGE>
                                                                   Exhibit 10.24

                            AMICUS THERAPEUTICS, INC.

                        2007 EMPLOYEE STOCK PURCHASE PLAN

      The following constitute the provisions of the 2007 Employee Stock
Purchase Plan of Amicus Therapeutics, Inc.

1.    PURPOSE

      The purpose of the Plan is to provide employees of the Company and its
Designated Subsidiaries with an opportunity to purchase Common Stock of the
Company. It is the intention of the Company to have the Plan qualify as an
"Employee Stock Purchase Plan" under Section 423 of the Code. The provisions of
the Plan shall, accordingly, be construed so as to extend and limit
participation in a manner consistent with the requirements of that section of
the Code.

2.    DEFINITIONS

      2.1. Board means the Board of Directors of the Company.

      2.2. Code means the Internal Revenue Code of 1986, as amended.

      2.3. Common Stock means the common stock, par value $0.01 per share, of
the Company.

      2.4. Company means Amicus Therapeutics, Inc., a Delaware corporation.

      2.5. Compensation means all regular straight time compensation including
commissions but shall not include payments for overtime, shift premium,
incentive compensation, incentive payments, bonuses and other irregular or
infrequent compensation or benefits.

      2.6. Continuous Status as an Employee means the absence of any
interruption or termination of service as an Employee. Continuous Status as an
Employee shall not be considered interrupted in the case of (i) sick leave; (ii)
military leave; (iii) any other leave of absence approved by the Administrator,
provided that such leave is for a period of not more than 90 days, unless
reemployment upon the expiration of such leave is guaranteed by contract or
statute, or unless provided otherwise pursuant to Company policy adopted from
time to time; or (iv) in the case of transfers between locations of the Company
or between the Company and its Designated Subsidiaries.

      2.7. Contributions means all amounts credited to the account of a
participant pursuant to the Plan.

      2.8. Corporate Transaction means a merger or consolidation of the Company
with and into another person or the sale, transfer, or other disposition of all
or substantially all of the Company's assets to one or more persons (other than
any wholly-owned subsidiary of the Company) in a single transaction or series of
related transactions.

      2.9. Designated Subsidiaries means the Subsidiaries which have been
designated by the Board from time to time in its sole discretion as eligible to
participate in the Plan.

<PAGE>
                                      -2-

      2.10. Employee means any person, including an Officer, who is customarily
employed for at least twenty (20) hours per week and more than five (5) months
in a calendar year by the Company or one of its Designated Subsidiaries.

      2.11. Entry Date shall mean the date an Employee first commences
participation in the Offering Period then in effect under the Plan.

      2.12 Exchange Act means the Securities Exchange Act of 1934, as amended.

      2.13. Offering Commencement Date means the first business day of each
Offering Period of the Plan.

      2.14. Offering Period means any of the successive periods provided for in
Section 4.1.

      2.15. Officer means a person who is an officer of the Company within the
meaning of Section 16 of the Exchange Act and the rules and regulations
promulgated thereunder.

      2.16. Offering Termination Date means the last business day of each
Offering Period of the Plan.

      2.17. Plan means this Employee Stock Purchase Plan.

      2.18. Purchase Period shall mean each successive period within an Offering
Period, as described in Section 4.2, at the end of which each participant shall
purchase Shares.

      2.19 Purchase Period Commencement Date means the first business day of
each Purchase Period.

      2.20 Purchase Period Termination Date means the last business day of each
Purchase Period.

      2.21 Purchase Price means with respect to a Purchase Period an amount
equal to eighty five percent (85%) of the (a) Fair Market Value (as defined in
Section 7.4 below) of a Share on the participant's Entry Date into the then
existing Offering Period or (b) the Fair Market Value on the Purchase Period
Termination Date, whichever is lower; provided, however, that if (i) there is an
increase in the number of Shares available for issuance under the Plan as a
result of a stockholder-approved amendment to the Plan, (ii) all or a portion of
such additional Shares are to be issued with respect to the Purchase Period
underway at the time of such increase ("Additional Shares"), and (iii) the Fair
Market Value of a Share of Common Stock on the date of such increase (the
"Approval Date Fair Market Value") is higher than the Fair Market Value
described in clause (a) above, then in such instance the Purchase Price with
respect to Additional Shares shall be eighty five percent (85%) of the Approval
Date Fair Market Value or the Fair Market Value of a Share of Common Stock on
the Purchase Period Termination Date, whichever is lower; and provided further,
that for each participant whose Entry Date is other than the Offering
Commencement Date of the Offering Period, the amount in clause (a) above shall
in no event be less than the Fair Market Value per Share on the Offering
Commencement Date of that Offering Period.

      2.22. Share means a share of Common Stock, as adjusted in accordance with
Section 18 of the Plan.

<PAGE>
                                      -3-

      2.23. Subsidiary means a corporation, in an unbroken chain of corporations
beginning with the Company if, at the time of the granting of the option, each
of the corporations other than the last corporation in the unbroken chain owns
stock possessing fifty percent (50%) or more of the total combined voting power
of all classes of stock in one of the other corporations in such chain.

3.    ELIGIBILITY

      3.1 Subject to the requirements of Sections 5.1 and the limitations
imposed by Section 423(b) of the Code, any person who is an Employee shall be
eligible to participate in an Offering Period under the Plan on the start date
of any Purchase Period within such Offering Period.

      3.2 Any provisions of the Plan to the contrary notwithstanding, no
Employee shall be granted an option under the Plan (i) if, immediately after the
grant, such Employee (taking into account stock which would be attributed to
such Employee pursuant to Section 424(d) of the Code) would own capital stock of
the Company and/or hold outstanding options to purchase stock possessing five
percent (5%) or more of the total combined voting power or value of all classes
of stock of the Company or of any Subsidiary of the Company, or (ii) if such
option would permit his or her rights to purchase stock under all employee stock
purchase plans (described in Section 423 of the Code) of the Company and its
Subsidiaries to accrue at a rate which exceeds Twenty-Five Thousand Dollars
($25,000) of the Fair Market Value (as defined in Section 7.4 below) of such
stock (determined on the basis of the Fair Market Value of such stock on the
date or dates such option was granted) for each calendar year in which such
option is outstanding at any time.

4.    OFFERING AND PURCHASE PERIODS

      4.1 Shares shall be offered for purchase under the Plan through a series
of successive or non-overlapping Offering Periods until such time as (i) the
maximum number of Shares available for issuance under the Plan shall have been
purchased or (ii) the Plan shall have been sooner terminated. Each Offering
Period shall be of such duration (not to exceed twenty-four (24) months) and
commence on such dates as determined by the Board or a committee designated by
the Board prior to the Offering Period Commencement Date and in accordance with
the terms of the Plan. At any time and from time to time, the Board may change
the duration and/or the frequency of Offering Periods or suspend operation of
the Plan with respect to Offering Periods not yet commenced.

      4.2 Each Offering Period shall be comprised of a series of successive (or
one) quarterly Purchase Periods. Unless otherwise established by the Board as of
any Offering Commencement Date, Purchase Periods shall commence on the first
business day in July, October, January and April each year and shall end on the
last business day in the following September, December, March and June,
respectively, each year.

5.    PARTICIPATION

      5.1. An eligible Employee may become a participant in the Plan by
completing a subscription agreement on the form provided by the Company and
filing it with the Company's payroll office prior to the Corporation's
enrollment deadlines for the Purchase Period during which such Employee desires
to enter the Offering Period, unless a later time for filing the subscription
agreement is set by the Board for all eligible Employees with respect to a given

<PAGE>
                                      -4-

Purchase Period. If the Employee meets the enrollment deadlines for the Purchase
Period, his or her Entry Date for purposes of the relevant Offering Period will
be the Purchase Period Commencement Date for that Purchase Period. The
subscription agreement shall set forth the percentage of the participant's
Compensation (subject to Section 6.1 below) to be paid as Contributions pursuant
to the Plan.

      5.2. Payroll deductions shall commence on the first payroll following the
Purchase Period Commencement Date and shall end on the last payroll paid on or
prior to the Purchase Period Termination Date, unless sooner terminated by the
participant as provided in Section 10.

6.    METHOD OF PAYMENT OF CONTRIBUTIONS

      6.1. A participant may elect to have payroll deductions made on each
payday during any Purchase Period in an amount not less than one percent (1%)
and not more than fifteen percent (15%) (or such other percentage as the Board
may establish from time to time before any Purchase Period Commencement Date) of
such participant's Compensation on each payday during the Purchase Period. All
payroll deductions made by a participant shall be credited to his or her account
under the Plan. A participant may not make any additional payments into such
account.

      6.2. A participant may discontinue his or her participation in the Plan as
provided in Section 10. In addition, if the Board has so announced to Employees
at least five (5) days prior to the scheduled beginning of the next Purchase
Period to be affected by the Board's determination, a participant may, on one
occasion only during each Purchase Period, change the rate of his or her
Contributions with respect to the Purchase Period by completing and filing with
the Company a new subscription agreement authorizing a change in the payroll
deduction rate. If otherwise permitted, no such change shall enable a
participant to resume Contributions other than as of an Offering Commencement
Date, following a withdrawal of Contributions during an Offering Period pursuant
to Section 10. Any such change in rate shall be effective as of the first
payroll period following the date of filing of the new subscription agreement,
if the agreement is filed at least ten (10) business days prior to such period
and, if not, as of the second following payroll period.

      6.3. Notwithstanding the foregoing, to the extent necessary to comply with
Section 423(b)(8) of the Code and Section 3.2 herein, a participant's payroll
deductions may be decreased during any Purchase Period to zero percent (0%).
Payroll deductions reduced to zero percent (0%) in compliance with this Section
6.3 shall re-commence automatically at the rate provided in such participant's
subscription agreement at the beginning of the next Purchase Period, unless
terminated by the participant as provided in Section 10.

7.    GRANT AND EXERCISE OF OPTIONS

      7.1. A participant shall be granted a separate purchase right for each
Offering Period in which he or she participates. The purchase right shall be
granted on the participant's Entry Date into the Offering Period and shall
provide the participant with the right to purchase Shares, in a series of
successive installments over the remainder of such Offering Period, upon the
terms set forth below.

      7.2 Each purchase right shall be automatically exercised in installments
on each Purchase Period Termination Date within the Offering Period, and Shares
shall accordingly be
<PAGE>
                                      -5-

purchased on behalf of each participant on each such Purchase Period Termination
Date. The purchase shall be effected by applying the Participant's payroll
deductions for the Purchase Period ending on such Purchase Period Termination
Date to the purchase of Shares (subject to the limitation on the maximum number
of Shares purchasable per Participant on any one Purchase Period Termination
Date) at the Purchase Price in effect for the Participant for that Purchase
Period Termination Date. No fractional shares shall be issued. The Shares
purchased upon exercise of an option hereunder shall be deemed to be transferred
to the participant on the Purchase Period Termination Date. During his or her
lifetime, a participant's option to purchase Shares hereunder is exercisable
only by him or her.

      7.3 The number of Shares purchasable by a participant on each Purchase
Period Termination Date during the Offering Period shall be determined by
dividing such Employee's Contributions accumulated during such Purchase Period
prior to such Purchase Period Termination Date and retained in the participant's
account as of the Purchase Period Termination Date by the applicable Purchase
Price. However, the maximum number of Shares an Employee may purchase during
each Purchase Period shall be 25,000 Shares, and provided further that such
purchase shall be subject to the limitations set forth in Sections 3.2 and 12.

      7.4. The fair market value of the Company's Common Stock on a given date
(the "Fair Market Value") means the value of a share of Common Stock on a
particular date determined by such methods or procedures as may be established
by the Committee. Unless otherwise determined by the Committee, the Fair Market
Value of the Common Stock as of any date, is the closing price for the Common
Stock as reported by The NASDAQ Global Market (or on any other national
securities exchange on which the Common Stock is then listed) for that date or,
if no closing price is reported for that date, the closing price on the next
preceding date for which a closing price was reported.

8.    [INTENTIONALLY LEFT BLANK]

9.    DELIVERY

      As promptly as practicable after each Purchase Period Termination Date of
each Offering Period, the Company shall arrange the delivery to each
participant, as appropriate, of a certificate representing the Shares purchased
upon exercise of his or her option. Any payroll deductions accumulated in a
participant's account which are not sufficient to purchase a full Share shall be
retained in the participant's account for the subsequent Purchase Period,
subject to earlier withdrawal by the participant as provided in Section 10
below. Any amounts left over in a participant's account after an Offering
Termination Date (or upon a withdrawal by a participant or upon a participant
purchasing the maximum dollar amount or number of shares hereunder) shall be
returned to the participant.

10.   VOLUNTARY WITHDRAWAL; TERMINATION OF EMPLOYMENT

      10.1. A participant may withdraw all but not less than all of the
Contributions credited to his or her account under the Plan at any time prior to
each Purchase Period Termination Date by giving written notice to the Company.
All of the participant's Contributions credited to his or her account will be
paid to him or her promptly after receipt of his or her notice of withdrawal and
his or her option for the current Purchase Period will be automatically
terminated, and no further Contributions for the purchase of Shares will be made
(or will be permitted to be made) during the Offering Period.

<PAGE>
                                      -6-

      10.2. Upon termination of the participant's Continuous Status as an
Employee prior to a Purchase Period Termination Date of an Offering Period for
any reason, including retirement or death, the Contributions credited to his or
her account will be returned to him or her or, in the case of his or her death,
to the person or persons entitled thereto under Section 14, and his or her
option will be automatically terminated.

      10.3. In the event an Employee fails to remain in Continuous Status as an
Employee of the Company for at least twenty (20) hours per week during the
Offering Period in which the employee is a participant, he or she will be deemed
to have elected to withdraw from the Plan and the Contributions credited to his
or her account and remaining there will be returned to him or her and his or her
option terminated.

      10.4. A participant's withdrawal during an Offering Period will not have
any effect upon his or her eligibility to participate in a succeeding Offering
Period or in any similar plan which may hereafter be adopted by the Company.

11.   INTEREST

      No interest shall accrue on the Contributions of a participant in the
Plan.

12.   STOCK

      12.1. Subject to adjustment as provided in Section 18, the maximum number
of Shares which shall be made available for sale under the Plan shall be 200,000
Shares. If the Board determines that, on a given Purchase Period Termination
Date, the number of shares with respect to which options are to be exercised may
exceed (i) the number of shares of Common Stock that were available for sale
under the Plan on the Purchase Period Commencement Date, or (ii) the number of
shares available for sale under the Plan on such Purchase Period Termination
Date, then the Company shall make a pro rata allocation of the Shares available
for purchase on such Purchase Period Termination Date in as uniform a manner as
shall be practicable and as it shall determine in its sole discretion to be
equitable among all participants exercising options to purchase Common Stock on
such Purchase Period Termination Date. The Company shall make pro rata
allocation of the Shares available on the Purchase Period Commencement Date of
the applicable Purchase Period pursuant to the preceding sentence,
notwithstanding any authorization of additional Shares for issuance under the
Plan by the Company's stockholders subsequent to such Purchase Period
Commencement Date.

      12.2. The participant shall have no interest or voting right in Shares
covered by his or her option until such option has been exercised.

      12.3. Shares to be delivered to a participant under the Plan will be
registered in the name of the participant or in the name of the participant and
his or her spouse, as directed by the participant.

13.   ADMINISTRATION

      The Board, or a committee named by the Board, shall supervise and
administer the Plan and shall have full power to adopt, amend and rescind any
rules deemed desirable and appropriate for the administration of the Plan and
not inconsistent with the Plan, to construe and interpret the Plan, and to make
all other determinations necessary or advisable for the administration of the

<PAGE>
                                      -7-

Plan. The Board's determinations made in good faith on matters referred to in
this Plan shall be final, binding and conclusive on all persons having or
claiming any interest under this Plan.

14.   DESIGNATION OF BENEFICIARY

      14.1. A participant may file a written designation of a beneficiary who is
to receive any Shares and cash, if any, from the participant's account under the
Plan in the event of such participant's death subsequent to the end of a
Purchase Period but prior to delivery to him or her of such Shares and cash. Any
such beneficiary shall also be entitled to receive any cash from the
participant's account under the Plan in the event of such participant's death
during a Purchase Period.

      14.2. Such designation of beneficiary may be changed by the participant at
any time by written notice. In the event of the death of a participant and in
the absence of a beneficiary validly designated under the Plan who is living at
the time of such participant's death, the Company shall deliver such Shares
and/or cash to the executor or administrator of the estate of the participant,
or if no such executor or administrator has been appointed (to the knowledge of
the Company), the Company, in its discretion, may deliver such Shares and/or
cash to the spouse or to any one or more dependents or relatives of the
participant, or if no spouse, dependent or relative is known to the Company,
then to such other person as the Company may designate.

15.   TRANSFERABILITY OF OPTIONS AND SHARES

      Neither Contributions credited to a participant's account nor any rights
with regard to the exercise of an option or to receive Shares under the Plan may
be assigned, transferred, pledged or otherwise disposed of in any way (other
than by will, the laws of descent and distribution, or as provided in Section
14) by the participant. Any such attempt at assignment, transfer, pledge or
other disposition shall be without effect, except that the Company may treat
such act as an election to withdraw funds in accordance with Section 10. In
addition, if the Board has so announced to Employees at least five (5) days
prior to the scheduled beginning of the next Purchase Period, any Shares
acquired on the Purchase Period Termination Date of such Purchase Period may be
subject to restrictions specified by the Board on the transfer of such Shares.
Any participant selling or transferring any or all of his or her Shares
purchased pursuant to the Plan must provide written notice of such sale or
transfer to the Company within five business days after the date of sale or
transfer. Such notice to the Company shall include the gross sales price, if
any, the Purchase Period during which the Shares being sold were purchased by
the participant, the number of Shares being sold or transferred and the date of
sale or transfer.

16.   USE OF FUNDS

      All Contributions received or held by the Company under the Plan may be
used by the Company for any corporate purpose, and the Company shall not be
obligated to segregate such Contributions from its other assets.

17.   REPORTS

      Individual accounts will be maintained for each participant in the Plan.
Statements of account will be given to participating Employees at least
annually, which statements will set forth the amounts of Contributions, the per
Share Purchase Price, the number of Shares purchased and the remaining cash
balance, if any.

<PAGE>
                                      -8-

18.   ADJUSTMENTS UPON CHANGES IN CAPITALIZATION; CORPORATE TRANSACTIONS

      18.1. Adjustment. All of the share numbers set forth in the Plan reflect
the capital structure of the Company immediately after the closing of the
initial public offering of the Company's Common Stock. Subject to any required
action by the stockholders of the Company, the number of shares covered by each
option under the Plan which has not yet been exercised and the number of Shares
which have been authorized for issuance under the Plan but have not yet been
placed under option (collectively, the "Reserves"), as well as the maximum
number of shares of Common Stock which may be purchased by a participant in an
Offering Period, the number of shares of Common Stock set forth in Section 12.1
above, and the price per Share of Common Stock covered by each option under the
Plan which has not yet been exercised, shall be proportionately adjusted for any
increase or decrease in the number of the Company's issued Shares resulting from
a stock split, reverse stock split, stock dividend, combination or
reclassification of the Common Stock (including any such change in the number of
Shares of Common Stock effected in connection with a change in domicile of the
Company), or any other increase or decrease in the number of Shares effected
without receipt of consideration by the Company; provided however that
conversion of any convertible securities of the Company shall not be deemed to
have been "effected without receipt of consideration." Such adjustment shall be
made by the Board, whose determination in that respect shall be final, binding
and conclusive.

      18.2. Corporate Transactions. In the event of a dissolution or liquidation
of the Company, the Offering Period then in progress will terminate immediately
prior to the consummation of such action, unless otherwise provided by the
Board. In the event of a Corporate Transaction, each option outstanding under
the Plan shall be assumed or an equivalent option shall be substituted by the
successor corporation or a parent or Subsidiary of such successor corporation.
In the event that the successor corporation refuses to assume or substitute for
outstanding options, the Offering Period then in progress shall be shortened and
a new Offering Termination Date shall be set (the "New Offering Termination
Date"), as of which date the Offering Period then in progress will terminate.
The New Offering Termination Date shall be on or before the date of consummation
of the transaction and the Board shall notify each participant in writing, at
least ten (10) days prior to the New Offering Termination Date, that the
Offering Termination Date for his or her option has been changed to the New
Offering Termination Date and that his or her option will be exercised
automatically on the New Offering Termination Date, unless prior to such date he
or she has withdrawn from the Offering Period as provided in Section 10. For
purposes of this Section 18, an option granted under the Plan shall be deemed to
be assumed, without limitation, if, at the time of issuance of the stock or
other consideration upon a Corporate Transaction, each holder of an option under
the Plan would be entitled to receive upon exercise of the option the same
number and kind of shares of stock or the same amount of property, cash or
securities as such holder would have been entitled to receive upon the
occurrence of the transaction if the holder had been, immediately prior to the
transaction, the holder of the number of Shares of Common Stock covered by the
option at such time (after giving effect to any adjustments in the number of
Shares covered by the option as provided for in this Section 18); provided
however that if the consideration received in the transaction is not solely
common stock of the successor corporation or its parent (as defined in Section
424(e) of the Code), the Board may, with the consent of the successor
corporation, provide for the consideration to be received upon exercise of the
option to be solely common stock of the successor corporation or its parent
equal in fair market value to the per Share consideration received by holders of
Common Stock in the transaction.

<PAGE>
                                      -9-

      The Board may, if it so determines in the exercise of its sole discretion,
also make provision for adjusting the Reserves, as well as the price per Share
of Common Stock covered by each outstanding option, in the event that the
Company effects one or more reorganizations, recapitalizations, rights offerings
or other increases or reductions of Shares of its outstanding Common Stock, and
in the event of the Company's being consolidated with or merged into any other
corporation.

19.   AMENDMENT OR TERMINATION

      19.1. The Board may at any time and for any reason terminate or amend the
Plan. Except as provided in Section 18, no termination of the Plan may affect
options previously granted, provided that the Plan or an Offering Period may be
terminated by the Board on a Offering Period Termination Date or by the Board's
setting a new Offering Period Termination Date with respect to an Offering
Period then in progress if the Board determines that termination of the Plan
and/or any Offering Period is in the best interests of the Company and its
stockholders or if continuation of the Plan and/or a Purchase Period or an
Offering Period would cause the Company to incur adverse accounting charges as a
result of the Plan. Except as provided in Section 18 and in this Section 19, no
amendment to the Plan shall make any change in any option previously granted
which adversely affects the rights of any participant.

      19.2. In addition to the foregoing, without stockholder consent and
without regard to whether any participant rights may be considered to have been
adversely affected, the Board (or its committee) shall be entitled to change the
Offering Periods, limit the frequency and/or number of changes in the amount
withheld during an Offering Period, establish the exchange ratio applicable to
amounts withheld in a currency other than U.S. dollars, permit payroll
withholding in excess of the amount designated by a participant in order to
adjust for delays or mistakes in the Company's processing of properly completed
withholding elections, establish reasonable waiting and adjustment periods
and/or accounting and crediting procedures to ensure that amounts applied toward
the purchase of Common Stock for each participant properly correspond with
amounts withheld from the participant's Compensation, and establish such other
limitations or procedures as the Board (or its committee) determines in its sole
discretion advisable which are consistent with the Plan.

20.   NOTICES

      Any notice, demand, request or other communication hereunder to any party
shall be deemed to be sufficient if contained in a written instrument delivered
in person or duly sent by first class registered, certified or overnight mail,
postage prepaid, or telecopied with a confirmation copy by regular, certified or
overnight mail, addressed or telecopied, as the case may be, (i) if to the
recipient of an Award, at his or her residence address last filed with the
Company and (ii) if to the Company, at its principal place of business,
addressed to the attention of its Chief Executive Officer, or to such other
address or telecopier number, as the case may be, as the addressee may have
designated by notice to the addressor. All such notices, requests, demands and
other communications shall be deemed to have been received: (i) in the case of
personal delivery, on the date of such delivery; (ii) in the case of mailing,
when received by the addressee; and (iii) in the case of facsimile transmission,
when confirmed by facsimile machine report connection with the Plan shall be
deemed to have been duly given when received in the form specified by the
Company at the location, or by the person, designated by the Company for the
receipt thereof.

<PAGE>
                                      -10-

21.   CONDITIONS TO ISSUANCE OF SHARES

      Shares shall not be issued with respect to an option unless the exercise
of such option and the issuance and delivery of such Shares pursuant thereto
shall comply with all applicable provisions of law, domestic or foreign,
including, without limitation, the Securities Act of 1933, as amended, the
Exchange Act, the rules and regulations promulgated thereunder, applicable state
securities laws and the requirements of any stock exchange upon which the Shares
may then be listed, and shall be further subject to the approval of counsel for
the Company with respect to such compliance.

      As a condition to the exercise of an option, the Company may require the
person exercising such option to represent and warrant at the time of any such
exercise that the Shares are being purchased only for investment and without any
present intention to sell or distribute such Shares if, in the opinion of
counsel for the Company, such a representation is required by any of the
aforementioned applicable provisions of law.

22.   TERM OF PLAN; EFFECTIVE DATE

      The Plan shall become effective immediately after the closing of the
initial public offering of the Company's Common Stock. It shall continue in
effect for a term of ten (10) years unless sooner terminated under Section 19.

<PAGE>
                                                  FORM OF SUBSCRIPTION AGREEMENT

                           AMICUS THERAPEUTICS, INC.

                        2007 EMPLOYEE STOCK PURCHASE PLAN

                             SUBSCRIPTION AGREEMENT

New Election: ____

Change of Election: ___

      1. I, __________________, hereby elect to participate in the Amicus
Therapeutics, Inc. 2007 Employee Stock Purchase Plan (as amended, the "Plan")
for the Offering Period ______________ ___, ______ to ______________ ___, _____,
and subscribe to purchase shares of the Company's Common Stock in accordance
with this Subscription Agreement and the Plan.

      2. I elect to have Contributions in the amount of _____% of my
Compensation, as those terms are defined in the Plan, applied to this purchase.
I understand that this amount must not be less than 1% and not more than 15% of
my Compensation during the Offering Period. (Please note that no fractional
percentages are permitted).

      3. I hereby authorize payroll deductions from each paycheck during the
Offering Period at the rate stated in Item 2 of this Subscription Agreement. I
understand that all payroll deductions made by me shall be credited to my
account under the Plan and that I may not make any additional payments into such
account. I understand that all payments made by me shall be accumulated, without
interest or earnings, for the purchase of shares of Common Stock at the
applicable purchase price determined in accordance with the Plan. I further
understand that, except as otherwise set forth in the Plan, shares will be
purchased for me automatically on each Purchase Period Termination Date of each
Purchase Period unless I otherwise withdraw from the Plan by giving written
notice to the Company for such purpose.

      4. I understand that I may discontinue at any time prior to the Offering
Termination Date my participation in the Plan as provided in Section 10 of the
Plan. I acknowledge that, unless I discontinue my participation in the Plan as
provided in Section 10 of the Plan, my election will continue to be effective
for each successive Offering Period.

      5. I have received a copy of the complete Amicus Therapeutics, Inc. 2007
Employee Stock Purchase Plan. I understand that my participation in the Plan is
in all respects subject to the terms of the Plan.

      6. Shares purchased for me under the Plan should be issued in the name(s)
of (name of employee or employee and spouse only):

                    __________________________

                    __________________________

<PAGE>
                                      -2-

      7. In the event of my death, I hereby designate the following as my
beneficiary(ies) to receive all payments and shares due to me under the Plan:

NAME: (Please print)                     _______________________________________
                                         (First)       (Middle)         (Last)

__________________________               _______________________________________
(Relationship)                           (Address)

                                         _______________________________________

      8. I understand that if I dispose of any shares received by me pursuant to
the Plan within 2 years after my Entry Date into the then current Offering
Period (the first day of the first Purchase Period in the Offering Period during
which I purchased such shares) or within 1 year after the applicable Purchase
Period Termination Date (the last day of the Purchase Period during which I
purchased such shares), I will be treated for federal income tax purposes as
having received ordinary compensation income at the time of such disposition in
an amount equal to the excess of the fair market value of the shares on the
Purchase Period Termination Date over the price which I paid for the shares,
regardless of whether I disposed of the shares at a price less than their fair
market value at the Purchase Period Termination Date. The remainder of the gain
or loss, if any, recognized on such disposition will be treated as capital gain
or loss.

      I hereby agree to notify the Company in writing within 30 days after the
date of any such disposition, and I will make adequate provision for federal,
state or other tax withholding obligations, if any, which arise upon the
disposition of the Common Stock. The Company may, but will not be obligated to,
withhold from my compensation the amount necessary to meet any applicable
withholding obligation including any withholding necessary to make available to
the Company any tax deductions or benefits attributable to the sale or early
disposition of Common Stock by me.

      9. If I dispose of such shares at any time after expiration of the 2-year
and 1-year holding periods, I understand that I will be treated for federal
income tax purposes as having received compensation income only to the extent of
an amount equal to the lesser of (1) the excess of the fair market value of the
shares at the time of such disposition over the purchase price which I paid for
the shares under the option, or (2) 15% of the fair market value of the shares
on my Entry Date for the current Offering Period. The remainder of the gain or
loss, if any, recognized on such disposition will be treated as capital gain or
loss.

      I understand that this tax summary is only a summary and is subject to
change. I further understand that I should consult a tax advisor concerning
certain tax implications of the purchase and sale of stock under the Plan.

      10. I hereby agree to be bound by the terms of the Plan. The effectiveness
of this Subscription Agreement is dependent upon my eligibility to participate
in the Plan.

                              SIGNATURE: _______________________________________

                              SOCIAL SECURITY #: _______________________________

                              DATE: ____________________________________________

<PAGE>

                                                    FORM OF NOTICE OF WITHDRAWAL

                            AMICUS THERAPEUTICS, INC.

                        2007 EMPLOYEE STOCK PURCHASE PLAN

                              NOTICE OF WITHDRAWAL

      I, _____________, hereby elect to withdraw my participation in the Amicus
Therapeutics, Inc. 2007 Employee Stock Purchase Plan (the "Plan") for the
Purchase Period that began on _________________, ________. This withdrawal
covers all Contributions credited to my account following the Purchase Period
Commencement Date and is effective on the date designated below.

      I understand that all such Contributions credited to my account will be
paid to me within ten (10) business days of receipt by the Company of this
Notice of Withdrawal and that my option for the current Purchase Period will
automatically terminate, and that no further Contributions for the purchase of
shares can be made by me during the current Offering Period.

      The undersigned further understands and agrees that he or she shall be
eligible to participate in succeeding Offering Periods only by delivering to the
Company a new Subscription Agreement.

Dated: _________________________          ______________________________________
                                                 Signature of Employee

                                          ______________________________________
                                                 Social Security Number

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00123-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00123-of-00352.parquet"}]]