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                                                                    EXHIBIT 10.1

                             CONFIDENTIAL TREATMENT

                                    AGREEMENT

      This Agreement, dated as of July 30, 2001, (the "Effective Date") is by
and, between Albany Molecular Research, Inc., a Delaware corporation, located at
21 Corporate Circle, P.O. Box 15098, Albany, New York 15098 ("AMRI"), and CUBIST
Pharmaceuticals, Inc., a Delaware corporation with a place of business at 24
Emily Street, Cambridge, Massachusetts 02139 ("CUBIST").

      NOW, THEREFORE, in consideration of the mutual promises and other good and
valuable consideration, the parties agree as follows:

      SECTION 1. - Definitions.

      The terms used in this Agreement have the following meaning:

      1.1 "AFFILIATE" with respect to any Party, shall mean any Person whether
de jure or de facto, controlling, controlled by, or under common control with,
such Party. For these purposes, "control" shall refer to (a) the possession,
directly or indirectly, of the power to direct the management or policies of a
Person, whether through the ownership of voting securities, by contract or
otherwise or (b) the ownership, directly or indirectly, of at least 50% (or such
lesser percentage which is the maximum allowed to be owned by a foreign
corporation in a particular jurisdiction of the voting securities or other
ownership interest of a Person).

      1.2 "AMRI BACKGROUND PATENTS" means claims of any and all patents and
patent applications [*] that are owned by AMRI as of the Effective Date and that
claim a [*] that was used by AMRI in producing AMRI Derivatives pursuant to the
Research Program.

      1.3 "AMRI DERIVATIVE" means (i) a compound(s) prepared by AMRI pursuant to
the Research Program and that is either a derivative of [*] developed or
practiced by AMRI, or a derivative of any such [*] developed or practiced by
AMRI, and/or (ii) compound(s) prepared by CUBIST or its Affiliates or
Sublicensees that are [*] in (i).

      1.4 "AMRI PROCESS TECHNOLOGY" means the data, know-how and information
that is required to produce [*] used by AMRI in the Research Program, whether
patented or not.

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      1.5 "[*] PROCESS" means [*] procedure or [*] used by AMRI to prepare
derivatives of [*] and, without limitation, any process or procedure using [*]
under this Agreement.

      1.6 "COMBINATION PRODUCT" shall mean a CUBIST Product that includes an
AMRI Derivative or a CUBIST Derivative and one or more additional active agents.

      1.7 "CUBIST DERIVATIVE" means a compound prepared by CUBIST or its
Affiliates or Sublicensees or any of their agents, consultants or collaborators
that is directly based upon or directly derived from an AMRI Derivative.

      1.8   "CUBIST PRODUCT" means either an
(a) "AMRI Derivative Product" which is a product (i) the making, using, selling,
offering for sale, or import of which would, but for the licenses granted
herein, infringe a valid claim of a Research Patent or (ii) that includes an
AMRI Derivative; or

(b) "CUBIST Derivative Product" which is a product containing a CUBIST
Derivative.

      1.9 "FDA" means the United States Food and Drug Administration, or the
successor thereto.

      1.10 "FTE" means a full time equivalent person year of scientific or
technical work, working forty hours per week for at least 48 weeks.

      1.11 "FIRST COMMERCIAL SALE" means, with respect to any CUBIST Product in
a country of the Territory, the first sale of a CUBIST Product by CUBIST, its
Affiliates, distributors or Sublicensees to a Third Party, in such country
anywhere in the Territory, after all required marketing and pricing approvals
have been granted, or otherwise permitted, by the governing health authority of
such country. "First Commercial Sale" shall not include the sale of any CUBIST
Product for use in clinical trials or for compassionate use prior to the grant
of regulatory approval.

      1.12 "IND" shall mean an investigational new drug application filed with
the FDA for approval to commence human clinical trials, or the equivalent
application in other countries or regulatory jurisdictions.

      1.13 "MAJOR MARKETS" means the [*].

      1.14 "NET SALES" means, with respect to any CUBIST Product, the gross
amount received by CUBIST, its Affiliates, Sublicensees, distributors

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or co-marketers for sale of CUBIST Product to an independent Third Party in a
bona fide arms length transaction less deductions for: (i) trade, quantity
and/or cash discounts, allowances and rebates actually allowed or given; (ii)
freight, shipping, insurance and other transportation expenses (if separately
identified in such invoice); (iii) credits or refunds actually allowed for
rejections, or defects of such CUBIST Product, outdated or returned CUBIST
Product, or because of rebates or retroactive price reductions; and (iv) sales,
value-added, excise taxes, tariffs and duties, and other taxes directly related
to the sale and except for excise taxes, only to the extent that such items are
separately identified in such invoice. If a CUBIST Product is a Combination
Product, then Net Sales shall be calculated by multiplying the actual Net Sales
of such Combination Product by the fraction A/(A+B) where A is the invoice price
of the AMRI Derivative or CUBIST Derivative if sold separately, and B is the
total invoice price of the other active ingredient or ingredients in the
combination, if sold separately. If, on a country-by-country basis, the other
active ingredient or ingredients in the combination are not sold separately in
said country, Net Sales for the purpose of determining royalties of the
combination product shall be calculated by multiplying actual Net Sales of such
combination product by the fraction A/C where A is the invoice price of the AMRI
Derivative or CUBIST Derivative if sold separately, and C is the invoice price
of the combination product.

      1.15 "PARTY" means AMRI or CUBIST and, when used in the plural, means AMRI
and CUBIST.

      1.16 "PERSON" means any natural person, corporation, firm, business trust,
joint venture, association, organization, company, partnership or other business
entity, or any government or any agency or political subdivision thereof.

      1.17 "RESEARCH PATENTS" means any and all patents or patent applications
that are invented by an employee(s) of AMRI pursuant to the Research Program
(alone or jointly with an employee of CUBIST) and claim AMRI Process Technology,
AMRI Derivatives, or the use thereof.

      1.18 "RESEARCH PLANS" means the plans for Stage I Research and Stage II
Research attached as Appendix A.

      1.19 "RESEARCH PROGRAM" means research performed by the Parties pursuant
to the Research Plans.

      1.20 "ROYALTY TERM" means, with respect to each CUBIST Product in each
country in the Territory the period of time commencing on the Effective

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Date in such country and ending on the later of (i) [*] from the date of the
First Commercial Sale of such CUBIST Product in such country, or (ii) the date
on which the CUBIST Product in the country where manufactured, used, sold or
offered for sale no longer infringes (a) a Valid Claim of a Research Patent or
(b) a Valid Claim of an AMRI Background Patent but for the licenses granted
herein.

      1.21. "STAGE I RESEARCH PLAN" means the stage I research as described in
the plan attached as Appendix A and any amendment thereto agreed to in writing
by the Parties.

      1.22 "STAGE II RESEARCH PLAN" means the stage II research as described in
the plan attached as Appendix A and any amendment thereto agreed to in writing
by the Parties.

      1.23 "SUBLICENSEE" shall mean a Third Party to which CUBIST has granted a
license and/or sub-sublicense rights under the licenses granted to CUBIST
hereunder.

      1.24 "THIRD PARTY" means any Person who or which is neither a Party nor,
with respect to a Party, an Affiliate of that Party.

      1.25 "VALID CLAIM" means (i) any claim of a pending patent application
which has not been pending for more than [*] and/or (ii) any claim of an
unexpired patent which has not been held unenforceable or invalid by a decision
of a court or other government agency of competent jurisdiction, unappealable or
unappealed within the time allowed for appeal, and which has not been
disclaimed, denied or admitted to be invalid or unenforceable through reissue or
disclaimer or otherwise.

2. RESEARCH PROGRAM

      2.1 STEERING COMMITTEE. Within [*] after the Effective Date, the Parties
shall form a Steering Committee for the Research Program. The Steering Committee
shall consist of [*] representatives of each Party and shall be responsible for
ensuring that the research plan is consistent with the goals and objectives of
the Research Program. The operation and authority of the Steering Committee
shall be as follows:

            (a) RESEARCH PROGRAM. The Steering Committee shall have general
authority over [*] and [*] of the Research Program. The Steering Committee shall
periodically review the Research Program from a strategic perspective and make
changes as it deems necessary to accomplish the purpose of the overall Research
Program.

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            (b) REVIEW OF ACTIVITIES. The Steering Committee shall periodically
review the results of the Research Program to ensure, to the extent reasonably
practical, that the Parties are meeting their commitments for both human and
financial support for the fulfillment of all contractual obligations between the
Parties.

            (c) REPRESENTATION. AMRI and CUBIST shall each appoint a minimum of
[*] representatives to serve on the Steering Committee. The representatives of a
Party may be changed from time to time at the discretion of that Party upon
written notification by the Party making such change to the other.

            (d) MEETINGS. The Steering Committee shall meet from time to time as
determined by the Steering Committee members. It is expected that the Steering
Committee shall meet in person at least [*] in each calendar year. The location
of Steering Committee meetings shall alternate between AMRI's and CUBIST's
offices unless otherwise agreed by the Parties, with the first meeting being
held at a CUBIST office. Consultants and non-representative employees of the
Parties may attend meetings of the Steering Committee as required to further the
Research Program. Minutes of all meetings setting forth decisions of the
Steering Committee relative to the Research Program will be prepared and
circulated by the Party hosting the meeting within [*] of such meeting. Such
minutes will become official when agreed to by all members of the Steering
Committee. Each Party will bear all expenses associated with attendance of its
employees and consultants at such meetings. If the Steering Committee members
all agree, a meeting may be held by means of telephone conference or similar
communications equipment by means of which all persons participating in the
meeting can hear each other. A quorum for a meeting shall require [*] of AMRI
and [*] of CUBIST.

            (e) DECISIONS. CUBIST will define the goals and objectives of the
program, and shall have the right to change the goals and objectives at any time
during the tern of this Agreement, provided such changes are put in writing and
provided to the Steering Committee. The Steering Committee shall make decisions
about the ways to technically achieve such goals and objectives, preferably by a
unanimous vote, with the representatives of each Party having one collective
vote. If a dispute arises, it shall be referred to the [*] of AMRI (or successor
position), and the [*] of CUBIST (or successor position) for further discussion
and resolution. These individuals shall, as soon as practicable, attempt in good
faith to resolve the dispute and, thereby, make the decision on behalf of the
Steering Committee. These individuals may obtain the advice of other employees
as they deem necessary or advisable in order to make the decision. If such
dispute is not resolved within

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[*] days after it has been referred to such persons for resolution, the dispute
shall be referred to CUBIST's [*] (or the applicable successor thereof), who
shall make the final decision regarding such dispute in good faith.

      2.2 AMRI shall perform research in accordance with the Stage I Research
Plan. The research for the Stage I Research Plan shall be performed over a [*]
period at a total cost of not more [*], which shall be paid in [*] equal [*]
installments, provided Stage 1 is not terminated prior to the completion of the
[*] period. The [*] installment shall be paid within [*] days of the Effective
Date, and each subsequent [*] installment shall be paid within [*] days of the
previous [*] installment.

      2.3 If the results of the Stage I Research are successful as determined by
[*], and [*] desires to proceed to Stage II, [*] shall select one or more AMRI
Derivatives for research pursuant to the Stage II Research Plan.

      2.4 Subject to [*] desire to proceed under Section 2.3, AMRI shall perform
research in accordance with the Stage II Research Plan for a period not to
exceed [*]. CUBIST shall pay AMRI [*] dollars [*] for [*] FTE's [*] for the
Stage II Research, plus the cost of materials to the extent that CUBIST has
provided prior authorization for such costs. CUBIST shall pay the first [*]
payment to AMRI for the Stage II Research within [*] days after commencement of
the Stage II Research, and shall make each of the subsequent payments on a [*]
basis thereafter. CUBIST shall pay AMRI for the cost of materials within [*]
days of receipt of an invoice therefor. The parties anticipate that AMRI shall
provide to CUBIST approximately [*] mgs of each of [*] AMRI Derivatives having
at least [*] purity within [*] of the initiation of Stage II, and it is
expressly understood that the achievement thereof is not an obligation or
requirement of this Agreement

      2.5 CUBIST shall screen for biological activity of AMRI Derivatives
provided by AMRI to CUBIST and CUBIST shall report all results of all such
screening to AMRI.

3. SUPPLY OF SELECTED AMRI DERIVATIVES

      3.1 (a) With respect to supply of AMRI Derivatives for [*], CUBIST agrees
that AMRI shall have the sole and exclusive right of first negotiation, for a
period of [*] days, to negotiate with CUBIST the terms and conditions of an
agreement by which AMRI will supply to CUBIST CUBIST's requirements for AMRI
Derivatives for such purposes. Either Party can initiate such [*] period by
written notice to the other Party, provided such written notice is given no
earlier than the time that CUBIST notifies AMRI in writing which AMRI Derivative
CUBIST has selected for [*] (the "Selected

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AMRI Derivative"). Upon receipt of written notice to initiate the negotiation
period, the Parties shall negotiate in good faith the terms and conditions of a
supply agreement for a period of [*].

            (b) If the Parties fail to reach agreement in such period, CUBIST
shall have the right to supply or have supplied by a Third Party the Selected
AMRI Derivative. CUBIST will have the right to produce or have produced the
Selected AMRI Derivative by use of [*] Processes, and/or AMRI's proprietary
synthesis technology that exists at such time. In no event shall AMRI have the
right to provide or license such AMRI Derivatives to any Third Party.

4. GRANT OF LICENSES AND ASSIGNMENT

      4.1 LICENSE.

            (a) AMRI hereby grants to CUBIST and its Affiliates a worldwide,
exclusive, royalty-bearing license with the right to grant sublicenses in
accordance with the terms of this Agreement, under AMRI's interest in Research
Patents, AMRI Process Technology and AMRI Background Patents to develop,
register, use, make, have made, import, export, offer to sell, and sell CUBIST
Products.

            (b) CUBIST agrees that it will use AMRI Process Technology, Research
Patents and AMRI Background Patents only for CUBIST PRODUCTS as licensed under
this Agreement, only as long as licensed under this Agreement and in each case
in accordance with the terms and conditions of this Agreement.

      4.2 SUBLICENSING BY CUBIST.

            (a) CUBIST shall have the right to grant sublicenses to a Third
Party under the licenses granted pursuant to Section 4.1 provided that (i) such
sublicense does not substantively alter AMRI's rights or CUBIST's obligations to
AMRI hereunder, and (ii) each Sublicensee agrees in writing to comply with
Sections 8.3, 8.4, 10, 11.1(b), 11.2 and 11.3 of this Agreement,

            (b) Any sublicense granted by CUBIST to a Third Party shall include
a provision [*] and a provision [*] in the event that the license [*].

      4.3 No right or license is granted to CUBIST hereunder except as expressly
granted under Section 4.1.

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5. DEVELOPMENT AND COMMERCIALIZATION.

      5.1 DEVELOPMENT EFFORTS BY CUBIST.

            (a) CUBIST will use reasonable efforts consistent with the efforts
exerted by CUBIST in pursuing the development and commercialization of its other
products of similar stage, technical challenge and economic potential, [*], to
develop and commercialize [*] CUBIST Product in a Major Market. In the event
that CUBIST is not interested in pursuing development and/or commercialization
of a AMRI Derivative Product in any country or countries, CUBIST shall promptly
notify AMRI, and [*]. Notwithstanding the foregoing, in no event is CUBIST
obligated to grant such rights.

      5.2 REPORTING.

            Within [*] days after the end of each calendar year, CUBIST shall
provide to AMRI an annual project status report (including the status of
regulatory approvals) of the development, and registration of each AMRI
Derivative Product. All such reports by CUBIST shall be treated as Confidential
Information of CUBIST and shall be subject to the restrictions imposed under
Section 11.2. Within [*] days after the end of each calendar year, CUBIST shall
provide to AMRI an annual project status report of the development and
registration of each CUBIST Derivative Product. All such reports by CUBIST shall
be treated as Confidential Information of CUBIST and shall be subject to the
restrictions imposed under Section 11.2. In no event will CUBIST be required to
provide structural information of such CUBIST Derivative Product.

      5.3 REMEDY

      AMRI shall have the right to terminate this Agreement in its entirety by
written notice to CUBIST if CUBIST (i) has not filed an IND for a CUBIST Product
within [*] years of the Effective Date (ii) has not initiated a [*] for a CUBIST
Product within [*] years of the IND filing or (iii) has not initiated [*] for a
CUBIST Product within [*] years of the completion of a [*].

6. FEE; MILESTONE PAYMENTS AND ROYALTIES.

      6.1 MILESTONE PAYMENTS BY CUBIST. CUBIST shall pay AMRI each of the
following non-refundable and non-creditable milestone payments the first time
that each milestone is achieved for a CUBIST Product, whether achieved by
CUBIST, its Affiliates, its Sublicensee or distributor:

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            (a) [*] upon initiation of the first Phase I clinical study;

            (b) [*] upon commencement of the first Phase III clinical trial or
the equivalent thereof in any Major Market;

            (c) [*] upon the first filing for regulatory approval in any Major
Market;

            (d) [*] upon the first receipt of regulatory approval in any Major
Market;

            (e) In the event that any of the milestones of Section 6.1(a)-(d)
are achieved and one or more preceding milestone payments have not been made,
then the payment required by the preceding milestone(s) shall also be paid at
the same time. Cubist shall be obligated to pay each of milestone payments (a)
through (d) only once.

      6.2 ROYALTIES. In partial consideration of the rights and licenses granted
by AMRI to CUBIST under this Agreement, during the Royalty Term, CUBIST shall
pay to AMRI a royalty on Net Sales of CUBIST Products as follows:

            (a)   Royalties on Net Sales of AMRI Derivative Products
            (i)   [*] of aggregate Net Sales up to [*] dollars;
            (ii)  [*] of aggregate Net Sales over [*] dollars.

            (b) CUBIST will pay to AMRI a royalty of [*] of Net Sales of CUBIST
Derivative Products.

      In calculating the royalty due under this Section 6.2 with respect to Net
Sales of CUBIST Products during any period of less than a calendar year, the
foregoing thresholds for a calendar year Net Sales shall be prorated in
accordance with the duration of such period.

      6.3 OBLIGATION TO PAY ROYALTIES. The obligation to pay royalties to AMRI
under this Section 6 is imposed only once with respect to the same unit of
CUBIST Product regardless of the number of patents pertaining thereto. In the
case where the CUBIST Product is to be resold, there shall be no obligation to
pay royalties to AMRI under this Section 6 on sales of CUBIST Products between
CUBIST and its Affiliates or between any of them and its distributor,
co-marketer or Sublicensee, but in such instances the obligation to pay
royalties shall arise upon the resale based on Net Sales of the reseller.

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7. REPRESENTATIONS AND WARRANTIES.

      7.1 REPRESENTATIONS AND WARRANTIES OF BOTH PARTIES. Each Party represents
and warrants to the other Party that, as of the date of this Agreement, such
Party is duly organized and validly existing and has full corporate power and
authority to enter into this Agreement and to carry out the provisions hereof.
Additionally, AMRI and CUBIST each represents and warrants that its employees
and agents have an obligation to assign all rights in any intellectual property
to AMRI or CUBIST, respectively.

      7.2 UNLESS OTHERWISE SET FORTH IN THIS AGREEMENT, NEITHER AMRI NOR CUBIST
MAKES ANY OTHER REPRESENTATION OR WARRANTY HEREUNDER AND DISCLAIMS ALL OTHER
REPRESENTATIONS AND WARRANTIES, INCLUDING, BUT NOT LIMITED TO, WARRANTIES OF
MERCHANTABILITY OR FITNESS FOR USE OR WITH RESPECT TO THE VALIDITY,
ENFORCEABILITY, OR PATENTABILITY OF PATENTS OR THAT CUBIST PRODUCT WILL NOT
INFRINGE PATENT RIGHTS OF A THIRD PARTY.

8. PAYMENTS AND REPORTS.

      8.1 ROYALTY PAYMENTS. All royalty payments due hereunder shall be paid [*]
within [*] days of the end of each [*]. Each such payment shall be accompanied
by a statement, CUBIST Product by CUBIST Product and country-by-country (unless
otherwise mutually agreed in writing by the parties), of the amount of gross
sales used in calculating Net Sales, the calculation of Net Sales and the units
of CUBIST Product sold during such [*], the amount of royalties due on such Net
Sales, the conversion rates used in converting to United States Dollars and any
other information reasonably requested by AMRI to enable AMRI to determine
amounts it is owed hereunder.

      8.2 MODE OF PAYMENT. CUBIST shall make all payments required under this
Agreement as directed by AMRI from time to time in United States Dollars.
Whenever conversion from any foreign currency shall be required, such conversion
shall be at the average rate of exchange for the last twenty (20) business days
of the applicable calendar quarter as published in the Wall Street Journal, New
York edition.

      8.3 RECORDS RETENTION. CUBIST and its Affiliates and its Sublicensees,
distributors and co-marketers shall keep complete and accurate records
pertaining to the sale of CUBIST Products in the Territory and covering all
transactions from which Net Sales are derived for a period

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of three calendar years after the year in which such sales occurred, and in
sufficient detail to permit AMRI to confirm the accuracy of royalty payments due
hereunder.

      8.4 AUDIT REQUEST. At the request and expense (except as provided below
and no more than once each calendar year) of AMRI, CUBIST and its Affiliates and
its Sublicensees, distributors and co-marketers shall permit an independent,
certified public accountant jointly selected by AMRI and CUBIST, at reasonable
times and upon reasonable notice, to examine those records and all other
material documents directly relating to, or directly relevant to, Net Sales of
Cubist Product in the possession or control of CUBIST and/or its Affiliates or
its Sublicensees, distributors and co-marketers, for a period of three years
after such royalties have accrued. Said accountant shall sign an appropriate
confidentiality agreement with CUBIST, and shall not disclose to AMRI any
information other than information directly relating to said reports, royalties,
and payments. Results of any such examination shall be made available to both
Parties. If, as a result of any inspection of the books and records of CUBIST or
its Affiliates or its Sublicensees, distributors and co-marketers it is shown
that Cubist underpaid by more than 7 %, Cubist will pay for the costs associated
with the audit. Prompt adjustments shall be made by the Parties to reflect any
underpayment or overpayment determined to have been made as a result of such
audit.

      8.5 TAXES. In the event that CUBIST is required by the revenue authorities
in any country to withhold any tax, such amount shall be deducted from the
royalty or other payment to be made by CUBIST, and CUBIST shall notify AMRI and
promptly furnish AMRI with copies of any tax certificate or other documentation
evidencing such withholding. Each Party agrees to cooperate with the other Party
in claiming exemptions from such deductions or withholdings under any agreement
or treaty in effect.

9. INTELLECTUAL PROPERTY.

      9.1   OWNERSHIP OF INVENTIONS. Ownership of inventions shall be determined
            in accordance with U.S. Patent Laws; inventions shall be licensed as
            set forth in Article 4.

      9.2 RESEARCH PATENTS. In the event that a Research Patent is jointly owned
by both AMRI and Cubist, neither party may license such patent without obtaining
the prior written consent of the other.

      9.3 PATENT FILING, MAINTENANCE AND PROSECUTION.

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            (a) RESEARCH PATENTS CLAIMING DERIVATIVES ONLY. CUBIST shall file,
prosecute and maintain Research Patents claiming AMRI Derivatives at CUBIST's
cost and expense through patent counsel selected by CUBIST, and CUBIST shall
provide AMRI copies of all documentation relating to such patent activities,
with sufficient time for AMRI to review and provide comments thereto. CUBIST
shall disclose to AMRI the complete texts of all such patents and patent
applications filed by CUBIST, as well as all information received concerning the
institution or possible institution of any interference, opposition,
re-examination, reissue, revocation, nullification or any official proceeding
involving any Research Patents. AMRI shall have the right to review such pending
applications and other proceedings and make recommendations to CUBIST concerning
them and their conduct. AMRI and its employees agree to cooperate with CUBIST in
taking all steps which CUBIST believes reasonably necessary or desirable to
secure its rights on this property at CUBIST's cost.

      CUBIST shall give [*] days prior written notice to AMRI of any intent to
cease prosecution and/or maintenance of any Research Patents and, in such case,
on a county-by-country basis, shall permit AMRI, at its sole discretion, to
continue prosecution or maintenance at its own expense. If AMRI elects to
continue such prosecution or maintenance, AMRI shall notify CUBIST within such
[*] day period, and CUBIST shall execute such documents and perform such acts as
may be reasonably requested by AMRI to assign all of CUBIST's right, title and
interest in and to such Research Patents to AMRI and CUBIST's license to such
Research Patents shall terminate.

            (b) RESEARCH PATENTS CLAIMING DERIVATIVES AND PROCESSES. In the
event that Research Patents claim AMRI Process Technology or other processes for
making AMRI Derivatives, in addition to AMRI Derivatives, the patents shall be
filed, prosecuted and maintained by patent counsel selected jointly by Cubist
and AMRI, and the parties shall [*]. Such patent counsel shall represent both
AMRI and Cubist.

            (c) AMRI BACKGROUND PATENTS AND AMRI PROCESS TECHNOLOGY. Except as
set forth in (b) above, AMRI shall file, prosecute and maintain patents in AMRI
Background Patents, and AMRI Process Technology licensed to CUBIST hereunder.
AMRI shall provide CUBIST copies of all documentation relating to such patent
activities.

      9.4 INFRINGEMENT ACTIONS. Each of AMRI and/or CUBIST shall promptly notify
the other in writing of any alleged or threatened infringement of any patents
licensed hereunder, or of any allegation by a

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Third Party that the activity of either of the parties pursuant to this
Agreement infringes or may infringe the intellectual property rights of such
Third Party. In the event of the institution of any suit by a Third Party
against CUBIST, its Affiliates or its Sublicensees for patent infringement
involving the use, sale, distribution or marketing of any CUBIST Product, CUBIST
shall defend such action at its own expense. CUBIST shall have the right to
settle the suit or consent to an adverse judgment thereto, in its sole
discretion. During the pendency of such action, all royalties due hereunder
shall continue to be paid by CUBIST. CUBIST shall assume full responsibility for
the payment of any award for damages, or any amount due pursuant to any
settlement entered into by CUBIST with such Third Party.

      In the event a Third Party allegedly infringes an Research Patents which
do not have claims to an AMRI Derivative, then AMRI shall have the first right
to prosecute such action at its own expense and represented by counsel of its
own choice. In the event a claim in a Research Patent directed to an AMRI
Derivative is infringed, then Cubist shall have the right to participate in such
action represented by counsel of its own choice and at its own expense.

      Both Cubist and AMRI agree to cooperate fully with each other in the event
of any of offensive or defensive litigation.

10. INDEMNIFICATION.

      10.1 BY CUBIST. CUBIST shall indemnify and hold AMRI and its directors,
officers, employees, shareholders and agents, harmless from and against any and
all Third Party claims, suits or demands for liabilities, damages, losses, costs
and expenses (including the reasonable fees of attorneys and other
professionals) directly arising out of or directly resulting from the
development, manufacture, use, distribution or sale of any CUBIST Product by
CUBIST, its Affiliates, distributors, co-marketers or Sublicensees or any person
or entity that prepares or manufactures CUBIST Product or AMRI Derivatives or
CUBIST Derivatives for or on behalf of any, of the foregoing or any person or
entity who receives or obtains (directly or indirectly) CUBIST Product or AMRI
Derivatives from any of the foregoing, except those losses which arise out of
the gross negligence or intentional misconduct of AMRI.

      10.2 BY AMRI. AMRI shall indemnify and hold CUBIST and its directors,
officers, employees, shareholders and agents, harmless from and against any and
all Third Party claims, suits or demands for liabilities, damages, losses, costs
and expenses (including the reasonable fees of attorneys and other
professionals) directly arising out of or directly resulting

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                                       14

from work performed by AMRI pursuant to the Research Program, except those
losses which arise out of the gross negligence or intentional misconduct of
CUBIST and except for those losses as to which AMRI is indemnified pursuant to
Section 10.2.

      10.3 COSTS OF ENFORCEMENT. As the Parties intend complete indemnification,
the indemnifying Party shall also reimburse all costs and expenses of enforcing
any provision of this Section 10.

      10.4 CONDITIONS TO INDEMNIFICATION. A person or entity that intends to
claim indemnification under this Section (the "Indemnitee") shall promptly
notify the other Party (the "Indemnitor") of any loss, claim, damage, liability
or action in respect of which the Indemnitee intends to claim such
indemnification, and the Indemnitor shall assume the defense thereof with
counsel mutually satisfactory to the Indemnitee whether or not such claim is
rightfully brought; provided, however, that an Indemnitee shall have the right
to retain its own counsel, with the fees and expenses to be paid by the
Indemnitor if Indemnitor does not assume the defense, or if representation of
such Indemnitee by the counsel retained by the Indemnitor would be inappropriate
due to actual or potential differing interests between such Indemnitee and any
other person represented by such counsel in such proceedings. The indemnity
agreement in this Section shall not apply to amounts paid in settlement of any
loss, claim, damage, liability or action if such settlement is effected without
the consent of the Indemnitor, which consent shall not be withheld or delayed
unreasonably. The failure to deliver notice to the Indemnitor within a
reasonable time after the commencement of any such action, only if prejudicial
to its ability to defend such action, shall relieve such Indemnitor of any
liability to the Indemnitee under this Section, but the omission so to deliver
notice to the Indemnitor will not relieve it of any liability that it may have
to any Indemnitee otherwise than under this Section. The Indemnitee under this
Section, its employees and agents, shall cooperate fully with the Indemnitor and
its legal representatives in the investigations of any action, claim or
liability covered by this indemnification.

      10.5 Any and all licensees of CUBIST, with respect to CUBIST Product,
shall agree to the same indemnity as in Section 10.1 of this Agreement and AMRI
shall be made a Third Party beneficiary thereof with the right of enforcement.

11. CONFIDENTIALITY.

      11.1 CONFIDENTIALITY AND EXCEPTIONS.

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            (a) Except to the extent expressly authorized by this Agreement or
otherwise agreed to in writing, AMRI agrees that, it, its Affiliates and its
Sublicensees, if any, shall use reasonable efforts to keep, and to ensure that
their officers and directors keep completely confidential and shall not publish
or otherwise disclose and shall not use for any purpose any information
furnished to it by CUBIST, its Affiliates or its Sublicensees, if any, except to
the extent that it can be established by AMRI by competent proof that such
information: (i) is or hereafter becomes generally available to the public other
than by reason of any default by AMRI with respect to its confidentiality
obligations hereunder; (ii) was already known to AMRI as evidenced by prior
written documents in its possession; (iii) is disclosed to AMRI by a Third Party
who is not in default of any confidentiality obligation to CUBIST; or (iv) is
independently developed by or for AMRI without reference to or reliance upon the
information furnished by CUBIST ("Confidential Information"). Information
disclosed by one Party to the other shall remain the property of the disclosing
Party unless otherwise specified in this Agreement.

            (b) Except to the extent expressly authorized by this Agreement or
otherwise agreed to in writing, CUBIST agrees that, it, its Affiliates and its
Sublicensees, if any, shall use reasonable efforts to keep, and to ensure that
their officers and directors keep completely confidential and shall not publish
or otherwise disclose and shall not use for any purpose any information
furnished to it by AMRI, or its Affiliates, if any, except to the extent that it
can be established by CUBIST by competent proof that such information: (i) is or
hereafter becomes generally available to the public other than by reason of any
default by CUBIST with respect to its confidentiality obligations hereunder,
(ii) was already known to CUBIST as evidenced by prior written documents in its
possession; (iii) is disclosed to CUBIST by a Third Party who is not in default
of any confidentiality obligation to AMRI; or (iv) is independently developed by
or for AMRI without reference to or reliance upon the information furnished by
AMR1 ("Confidential Information"). Information disclosed by one Party to the
other shall remain the property of the disclosing Party unless otherwise
specified in this Agreement:

      11.2 Notwithstanding the foregoing, the Parties may disclose Confidential
Information (i) to governmental authorities to facilitate the issuance of
marketing approvals for a CUBIST Product, provided that reasonable measures
shall be taken to assure confidential treatment of such information, provided
the non-disclosing party is given prior written notice of such disclosure, (ii)
to Third Parties under appropriate terms and conditions, including
confidentiality provisions equivalent to those in this

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Agreement, for consulting, manufacturing, development, external testing,
marketing, clinical trials and licensing or potential licensing of CUBIST
Product in accordance with this Agreement; and (iii) to comply with applicable
laws or regulations (including, without limitation, to comply with SEC, NASDAQ
or stock exchange disclosure requirements) or order by a court or other
regulatory body having competent jurisdiction; provided that if a Party is
required to make any such disclosure of the other Party's Confidential
Information under (i)-(iii) above, it will to the extent practicable, give
reasonable advance notice to the other Party of such disclosure requirement and,
will use its reasonable best efforts to secure confidential treatment of such
Confidential Information required to be disclosed.

      11.3 The obligations of this Section 11 shall terminate [*] after the
termination of this Agreement.

12. TERM; TERMINATION.

      12.1 TERM

      This Agreement shall commence as of the Effective Date and, unless sooner
terminated as provided hereunder, shall expire as follows:

            (a) As to each CUBIST Product in each country in the Territory, this
Agreement shall expire upon the expiration of the Royalty Term with respect to
such CUBIST Product in such country.

            (b) This Agreement shall expire in its entirety upon the termination
of the Royalty Term with respect to all CUBIST Products in all countries in the
Territory.

      12.2 Notwithstanding the foregoing, CUBIST shall have the right to
terminate the Agreement at any time upon [*] to AMRI, provided that CUBIST pays
all amounts for work performed prior to the effective date of the termination.

      12.3 BREACH.

            (a) Failure by either Party to comply with any of its material
obligations contained in this Agreement shall entitle the other Party to give to
the Party in default notice specifying the nature of the default and requiring
it to cure such default. If such default is not cured within [*] days [*] days
in the event of a default with respect to an obligation to pay money) after
receipt of such notice, the notifying Party shall be entitled, without

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                                       17

prejudice to any of its other rights conferred on it by this Agreement, and in
addition to any other remedies available to it by law or in equity, to terminate
this Agreement in its entirety, by giving written notice to take effect
immediately upon delivery of such notice. The right of either Party to terminate
this Agreement, as provided in this Section 12.3, shall not be affected in any
way by its waiver or failure to take action with respect to any previous
default.

            (b) An election of remedy by a Party for a material breach of this
Agreement under this Section 12.3 on one occasion shall not constitute a waiver
as to any other remedy that may be available to such Party under this Section
12.3 as to any material breach on another occasion.

      12.4 EFFECT OF EXPIRATION OR TERMINATION.

            (a) Following expiration of this Agreement under Section 12.1 with
respect to a CUBIST Product in a country, CUBIST shall have the [*] in such
country under the license granted pursuant to [*] of this Agreement. Following
[*] in its entirety under [*], CUBIST shall have the [*] in all countries so
long as CUBIST continues to [*] provided for herein.

            (b) In the event that this Agreement in terminated by AMRI under
Section 12.3 as a result of CUBIST's failure to make payments owed to AMRI, or
under Section 5.3, CUBIST will grant AMRI a [*] to [*] containing [*], including
a [*].

      12.5 Either Party may terminate this Agreement, if, at any time, the other
Party becomes insolvent or the other Party shall file in any court or agency
pursuant to any statute or regulation of a country in the Territory a petition
of bankruptcy or insolvency or for reorganization or for an arrangement or for
the appointment of a receiver of trustee of the other Party or of its assets or
if the other Party proposes a written agreement of composition or extension of
its debts or if the other Party shall be served with an involuntary petition
against it, filed in any insolvency proceeding, and such petition shall not be
dismissed within [*] after filing thereof, or if the other party shall make an
assignment for the benefit of its creditors. Notwithstanding the bankruptcy of
AMRI or the impairment of performance of AMRI of its obligations under this
section, CUBIST shall be entitled to retain the licenses granted herein,
provided it continues to comply with its obligations to AMRI hereunder.

      12.6 ACCRUED RIGHTS, SURVIVING OBLIGATIONS.

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            (a) Termination, relinquishment or expiration of this Agreement for
any reason shall be without prejudice to any rights which shall have accrued to
the benefit of either Party prior to such termination, relinquishment or
expiration. Such termination, relinquishment or expiration shall not relieve
Party from obligations which are expressly indicated to survive termination or
expiration of this Agreement.

            (b) Termination, relinquishment or expiration of this Agreement
shall not terminate CUBIST's obligation to pay all royalties and other payments
that shall have accrued prior to such termination. All of the Parties' rights
and obligations under Sections 4.1 (b) and (c), 6.1, 6.2, 6.3, 8.1, 8.2, 8.3,
8.4, 8.5, 9.1, 9.2, 12.4(b), 12.6 and Articles 10, 11 and 14 shall survive
termination, relinquishment or expiration hereof.

      12.7 This Agreement may not be terminated by either Party except as
specifically provided in this Section 12.

13. FORCE MAJEURE.

      13.1 EVENTS OF FORCE MAJEURE. Neither Party shall be held liable or
responsible to the other Party nor be deemed to be in default under or in breach
of any provision of this Agreement for failure or delay in fulfilling or
performing any obligation of this Agreement when such failure or delay is due to
FORCE MAJEURE, and without the fault or negligence of the Party so failing or
delaying. For purposes of this Agreement, FORCE MAJEURE is defined as causes
beyond the control of the Party, including, without limitation, acts of God;
acts, regulations, or laws of any government; acts of regulatory or medical
advisory groups to the extent that it is beyond the control of a Party; war;
civil commotion; destruction of production facilities or materials by fire,
flood, earthquake, explosion or storm; labor disturbances; epidemic; and failure
of pubic utilities or common carriers. In such event CUBIST or AMRI, as the case
may be, shall immediately notify the other Party of such inability and ability
is expected to continue. The Party giving such notice shall thereupon be excused
from such of its obligations under this Agreement as it is thereby disabled from
performing for so long as it is so disabled, provided, that the Parry giving
such notice exerts reasonable efforts to resume such performance.

14. MISCELLANEOUS.

      14.1 RELATIONSHIP OF PARTIES. Nothing in this Agreement is intended or
shall be deemed to constitute a partnership, agency, employer-employee or joint
venture relationship between the Parties. No Party shall incur any

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debts or make any commitments for the other, except to the extent, if at all,
specifically provided herein.

      14.2 ASSIGNMENT. Neither Party shall, be entitled to assign its rights
hereunder without the express written consent of other Party hereto, which
consent shall not be unreasonably withheld, except that both CUBIST and AMRI may
otherwise assign their respective rights and transfer their respective duties
hereunder to any assignee of all or substantially all of their respective
businesses (or that portion thereof to which this Agreement relates) or in the
event of their respective merger or consolidation or similar transaction. CUBIST
may assign this Agreement to an Affiliate but such assignment shall not relieve
CUBIST of its obligations hereunder. No assignment and transfer shall be valid
or effective unless and until the assignee/transferee shall agree in writing to
be bound by the provisions of this Agreement in which case the Agreement will
inure to the benefit of such successors and assigns.

      14.3 FURTHER ACTIONS. Each Party agrees to execute, acknowledge and
deliver such further instruments, and to do all such other acts, as may be
necessary or appropriate in order to carry out the purposes and intent of this
Agreement.

      14.4 NOTICE. Any notice or request required or permitted to be given under
or in connection with this Agreement shall be deemed to have been sufficiently
given if in writing and personally delivered or sent by certified mail (return
receipt requested), facsimile transmission (receipt verified), or overnight
express courier service (signature required), prepaid, to the Party for which
such notice is intended, at the address set forth for such Party below:

            (a)   In the case of CUBIST, to:

                  Alan Watson, Ph.D, MBA
                  Senior Vice President, Corporate Development Cubist
                  Pharmaceuticals
                  24 Emily Street Cambridge, MA 02139 With a copy to:
                  Contract Manager

            (b)   In the case of AMRI, to:

                  Mr. David P. Waldek, CPA
                  Chief Financial Officer
                  Albany Molecular Research, Inc.
                  PO Box 15098

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                                       20

                  21 Corporate Circle
                  Albany, NY 12212-5098

or to such other address for such Party as it shall have specified by like
notice to the other Party, provided that notices of a change of address shall be
effective only upon receipt thereof. If delivered personally or by facsimile
transmission, the date of delivery shall be deemed to be the date on which such
notice or request was given. If sent by overnight express courier service, the
date of delivery shall be deemed to be the next business day after such notice
or request was deposited with such service. If sent by certified mail, the date
of delivery shall be deemed to be the third business day after such notice or
request was deposited with the U.S. Postal Service.

      14.5 USE OF NAME. Except as otherwise provided herein, neither Party shall
have any right, express or implied, to use in any manner the name or other
designation of the other Party or any other trade name or trademark of the other
Party for any purpose in connection with the performance of this Agreement.

      14.6 EXCLUSIVITY. AMRI expressly acknowledges that the during the term of
this Agreement, as a result of the exclusive licenses granted to CUBIST
hereunder, AMRI shall not have the right, directly or indirectly, itself or
through or in connection with any Third Party, to conduct research, develop,
make or market AMRI Derivatives, CUBIST Derivatives or daptomycin. AMRI further
agrees that for a period of [*] years after the termination of this Agreement,
it shall not directly or indirectly conduct research, develop, make or market
AMRI Derivatives, CUBIST Derivatives or daptomycin. CUBIST expressly
acknowledges that nothing in the terms of this Agreement shall prevent AMRI from
utilizing AMRI Background Patents AMRI Process Technology, or Research Patents
in any manner for compounds which are not AMRI Derivatives or CUBIST
Derivatives.

      14.6 PUBLIC ANNOUNCEMENTS. Except as required by law, rule or regulation
(including, without limitation, disclosure requirements of the U.S. Securities
and Exchange Commission, NASDAQ or any other stock exchange on which securities
issued by AMRI are traded), neither Party shall make any public announcement
concerning this Agreement or the subject matter hereof without the prior written
consent of the other, which shall not be unreasonably withheld. It shall not be
unreasonable for a Party to withhold consent with respect to any public
announcement containing any of such Party's Confidential Information. In the
event of a required or desired public announcement the Party making such
announcement shall provide the other Party with a copy of the proposed text
prior to such announcement sufficiently in advance of the scheduled release of
such announcement to

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afford such other Party a reasonable opportunity to review and comment upon the
proposed text. Once the text is approved, either Party may disclose the
substance of that which has been previously disclosed to the public.

      14.7 WAIVER. A waiver by either Party of any of the terms and conditions
of this Agreement in any instance shall not be deemed or construed to be a
waiver of such term or condition for the future, or of any subsequent. breach
hereof. All rights, remedies, undertakings, obligations and agreements contained
in this Agreement shall be cumulative and none of them shall be in limitation of
any other remedy, right, undertaking, obligation or agreement of either Party.

      14.8 COMPLIANCE WITH LAW. CUBIST and AMRI agree to comply with all
applicable laws, rules and regulations with respect to their activities under
this Agreement.

      14.9 SEVERABILITY. When possible, each provision of this Agreement will be
interpreted in such manner as to be effective and valid under applicable law,
but if any provision of this Agreement is held to be prohibited by or invalid
under applicable law, such provision will be ineffective only to the extent of
such prohibition or invalidity, without invalidating the remainder of this
Agreement and the parties shall negotiate, in good faith, a new provision which
will, as closely as possible, carry out the intentions of the parties provided
for in the invalidated provision. If such agreement is not reached in sixty (60)
days, the affected Party(ies) may terminate this Agreement.

      14.10 AMENDMENT. No amendment, modification or supplement of any
provisions of this Agreement shall be valid or effective unless made in writing
and signed by a duly authorized officer of each Party.

      14.11 GOVERNING LAW. This Agreement shall be governed by and interpreted
in accordance with the laws of the Commonwealth of Massachusetts without regard
to its choice of law principles. In the event that either Party desires to
initiate litigation with respect to this Agreement, such litigation shall be
conducted in an appropriate court in the Commonwealth of Massachusetts to the
extent possible.

      14.12 ENTIRE AGREEMENT. This Agreement, together with the Exhibits hereto,
sets forth the entire agreement and understanding between the Parties as to the
subject matter hereof and merges all prior discussions and negotiations between
them, and neither of the Parties shall be bound by any conditions, definitions,
warranties, understandings or representations with respect to such subject
matter other than as expressly provided herein or as

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duly set forth on or subsequent to the date hereof in writing and signed by a
proper and duly authorized officer or representative of the Party to be bound
thereby.

      14.13 PARTIES IN INTEREST. All the terms and provisions of this Agreement
shall be binding upon, inure to the benefit of and be enforceable by the Parties
hereto and their respective permitted successors and assigns.

      14.14 DESCRIPTIVE HEADINGS. The descriptive headings of this Agreement are
for convenience only, and shall be of no force or effect in construing or
interpreting any of the provisions of this Agreement.

      14.15 COUNTERPARTS. This Agreement may be executed simultaneously in any
number of counterparts, any one of which need not contain the signature of more
than one Party but all such counterparts taken together shall constitute one and
the same agreement.

      IN WITNESS WHEREOF, each of the Parties has caused this Agreement to be
executed by its duly authorized officer as of the day and year first above
written.

                                        ALBANY MOLECULAR RESEARCH, INC.

                                        By:    /s/ Thomas D'Ambra
                                           -------------------------------------

                                        Name:  Thomas D'Ambra
                                             -----------------------------------

                                        Title: Chairman and CEO
                                              ----------------------------------

                                        CUBIST PHARMACEUTICALS, INC.

                                        By:    /s/ Alan Watson
                                           -------------------------------------

                                        Name:  Alan Watson
                                            ------------------------------------

                                        Title: Sr Vice President
                                              ----------------------------------

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                                                                    EXHIBIT 10.2

================================================================================

                          CUBIST PHARMACEUTICALS, INC.

                  5 1/2% CONVERTIBLE SUBORDINATED NOTES DUE 2008

                            -------------------------

                                    INDENTURE

                          Dated as of October 26, 2001

                            -------------------------

                              The Bank of New York

                                     Trustee
                            -------------------------

================================================================================

<Page>

                                TABLE OF CONTENTS

                                   ARTICLE 1.

                          DEFINITIONS AND INCORPORATION
                                  BY REFERENCE

<Table>
<Caption>
                                                                                                PAGE
<S>            <C>                                                                                <C>
Section 1.01.  Definitions.........................................................................7
Section 1.02.  Other Definitions..................................................................14
Section 1.03.  Incorporation by Reference of Trust Indenture Act..................................15
Section 1.04.  Rules of Construction..............................................................15

                                   ARTICLE 2.
                                    THE NOTES

Section 2.01.  Form and Dating....................................................................16
Section 2.02.  Execution and Authentication.......................................................16
Section 2.03.  Registrar, Paying Agent and Conversion Agent.......................................17
Section 2.04.  Paying Agent to Hold Money in Trust................................................17
Section 2.05.  Holder Lists.......................................................................18
Section 2.06.  Transfer and Exchange..............................................................18
Section 2.07.  Replacement Notes..................................................................19
Section 2.08.  Outstanding Notes..................................................................19
Section 2.09.  Treasury Notes.....................................................................20
2.10.  Temporary Notes............................................................................20
Section 2.11.  Cancellation.......................................................................20
Section 2.12.  Additional Transfer and Exchange Requirements......................................21
Section 2.13.  CUSIP Numbers......................................................................26
Section 2.14.  Defaulted Interest.................................................................26

                                   ARTICLE 3.
                            REDEMPTION AND PREPAYMENT

Section 3.01.  Notices to Trustee.................................................................27
Section 3.02.  Selection of Notes to be Redeemed..................................................27
Section 3.03.  Notice of Redemption...............................................................28
Section 3.04.  Effect of Notice of Redemption.....................................................28
Section 3.05.  Deposit of Redemption Price........................................................29
Section 3.06.  Notes Redeemed in Part.............................................................29
Section 3.07.  Provisional and Optional Redemption................................................29
Section 3.08.  Mandatory Redemption...............................................................30
</Table>

<Page>

                                   ARTICLE 4.
                                   CONVERSION

<Table>
<S>            <C>                                                                                <C>
Section 4.01.  Conversion Privilege...............................................................30
Section 4.02.  Conversion Procedure...............................................................31
Section 4.03.  Fractional Shares..................................................................32
Section 4.04.  Taxes on Conversion................................................................32
Section 4.05.  Company to Provide Stock...........................................................32
Section 4.06.  Adjustment of Conversion Price.....................................................33
Section 4.07.  No Adjustment......................................................................37
Section 4.08.  Other Adjustments..................................................................37
Section 4.09.  Adjustments for Tax Purposes.......................................................38
Section 4.10.  Notice of Adjustment...............................................................38
Section 4.11.  Notice of Certain Transactions.....................................................38
Section 4.12.  Effect of Reclassifications, Consolidations, Mergers or Sales on Conversion........38
Section 4.13.  Trustee's Disclaimer...............................................................39
Section 4.14.  Voluntary Reduction................................................................40

                                   ARTICLE 5.
                                  SUBORDINATION

Section 5.01.  Agreement to Subordinate...........................................................40
Section 5.02.  Liquidation; Dissolution; Bankruptcy...............................................40
Section 5.03.  Default on Designated Senior Indebtedness..........................................41
Section 5.04.  Acceleration of Notes..............................................................41
Section 5.05.  When Distribution Must be Paid Over................................................42
Section 5.06.  Notice by Company..................................................................42
Section 5.07.  Subrogation........................................................................42
Section 5.08.  Relative Rights....................................................................43
Section 5.09.  Subordination May Not Be Impaired by Company.......................................43
Section 5.10.  Distribution or Notice to Representative...........................................43
Section 5.11.  Rights of Trustee and Paying Agent.................................................43
Section 5.12.  Authorization to Effect Subordination..............................................44
Section 5.13.  Amendments.........................................................................44
Section 5.14.  Agreement to Subordinate Unaffected................................................44
Section 5.15.  Certain Conversions Deemed Payment.................................................44

                                   ARTICLE 6.
                                    COVENANTS

Section 6.01  Payment of Notes....................................................................45
Section 6.02.  Maintenance of Office or Agency....................................................45
Section 6.03.  Reports............................................................................46
Section 6.04.  Rule 144A Information Requirement..................................................46
Section 6.05.  Compliance Certificate.............................................................47
Section 6.06.  Taxes..............................................................................47
Section 6.07.  Stay, Extension and Usury Laws.....................................................47
Section 6.08.  Corporate Existence................................................................47
Section 6.09.  Offer to Repurchase Upon Repurchase Event..........................................48
Section 6.10.  Payment of Additional Interest.....................................................52
</Table>

<Page>

                                   ARTICLE 7.
                                   SUCCESSORS
<Table>
<S>                                                                                               <C>
Section 7.01.  Merger, Consolidation, or Sale of Assets...........................................52
Section 7.02.  Successor Corporation Substituted..................................................52

                                   ARTICLE 8.
                              DEFAULTS AND REMEDIES

Section 8.01.  Events of Default..................................................................53
Section 8.02.  Acceleration.......................................................................54
Section 8.03.  Other Remedies.....................................................................54
Section 8.04.  Waiver of Past Defaults............................................................55
Section 8.05.  Control by Majority................................................................55
Section 8.06.  Limitation on Suits................................................................55
Section 8.07.  Rights of Holders of Notes to Receive Payment......................................56
Section 8.08.  Collection Suit by Trustee.........................................................56
Section 8.09.  Trustee May File Proofs of Claim...................................................56
Section 8.10.  Priorities.........................................................................57
Section 8.11.  Undertaking for Costs..............................................................57

                                   ARTICLE 9.
                                     TRUSTEE

Section 9.01.  Duties of Trustee..................................................................57
Section 9.02.  Rights of Trustee..................................................................58
Section 9.03.  Individual Rights of Trustee.......................................................59
Section 9.04.  Trustee's Disclaimer...............................................................59
Section 9.05.  Notice of Defaults.................................................................60
Section 9.06.  Reports by Trustee to Holders of the Notes.........................................60
Section 9.07.  Compensation and Indemnity.........................................................60
Section 9.08.  Replacement of Trustee.............................................................61
Section 9.09.  Successor Trustee by Merger, etc...................................................62
Section 9.10.  Eligibility; Disqualification......................................................62
Section 9.11.  Preferential Collection of Claims Against Company..................................62
</Table>

<Page>

                                   ARTICLE 10.
                           SATISFACTION AND DISCHARGE

<Table>
<S>             <C>                                                                               <C>
Section 10.01.  Satisfaction and Discharge........................................................63
Section 10.02.  Application of Trust Money........................................................64
Section 10.03.  Repayment to Company..............................................................64
Section 10.04.  Reinstatement.....................................................................64

                                   ARTICLE 11.
                        AMENDMENT, SUPPLEMENT AND WAIVER

Section 11.01  Without Consent of Holders of Notes................................................65
Section 11.02. With Consent of Holders of Notes...................................................66
Section 11.03. Compliance with Trust Indenture Act................................................67
Section 11.04. Revocation and Effect of Consents..................................................67
Section 11.05. Notation on or Exchange of Notes...................................................67
Section 11.06. Trustee to Sign Amendments, etc....................................................68

                                   ARTICLE 12.
                                  MISCELLANEOUS

Section 12.01. Trust Indenture Act Controls.......................................................68
Section 12.02. Notices............................................................................68
Section 12.03. Communication by Holders of Notes with Other Holders of Notes......................69
Section 12.04. Certificate and Opinion as to Conditions of Precedent..............................69
Section 12.05. Statements Required in Certificate or Opinion......................................70
Section 12.06. Rules by Trustee and Agents........................................................70
Section 12.07. No Personal Liability of Directors, Officers, Employees and Stockholders...........70
Section 12.08. Governing Law......................................................................70
Section 12.09. No Adverse Interpretation of Other Agreements......................................70
Section 12.10. Successors.........................................................................71
Section 12.11. Severability.......................................................................71
Section 12.12. Counterpart Originals..............................................................71
Section 12.13. Table of Contents, Heading, Etc....................................................71
</Table>

<Page>

                  TRUST INDENTURE ACT CROSS-REFERENCE TABLE (1)

<Table>
<Caption>
SECTION OF TRUST INDENTURE                            INDENTURE SECTION
ACT OF 1939, AS AMENDED

<S>                                                   <C>
310(a)............................................... 9.10
310(b)............................................... 9.08; 9.10
310(c)............................................... Inapplicable
311(a)............................................... 9.11
311(b)............................................... 9.11
311(c)............................................... Inapplicable
312(a)............................................... 2.05
312(b)............................................... 12.03
312(c)............................................... 12.03
313(a)............................................... 9.06
313(b)............................................... 9.06
313(c)............................................... 9.06
313(d)............................................... 9.06
314(a)............................................... 6.03; 6.05
314(b)............................................... Inapplicable
314(c)............................................... 12.04
314(d)............................................... Inapplicable
314(e)............................................... 12.05
314(f)............................................... Inapplicable
315(a)............................................... 9.01(b); 9.02(a)
315(b)............................................... 9.05
315(c)............................................... 9.01(a)
315(d)............................................... 9.01(c)
315(e)............................................... 8.11
316(a)............................................... 8.05
316(b)............................................... 8.06; 8.07
316(c)............................................... Inapplicable
317(a)............................................... 8.08; 8.09
317(b)............................................... 2.04
318(a)............................................... 12.01
</Table>

(1)     This Cross-Reference Table does not constitute part of the Indenture
        and shall not have any bearing on the interpretation of any of its terms
        or provisions.

<Page>

                                    EXHIBITS

Exhibit A        FORM OF NOTE

          INDENTURE dated as of October 26, 2001 between Cubist Pharmaceuticals,
Inc., a Delaware corporation (the "COMPANY"), and The Bank of New York, a New
York banking corporation, as trustee (the "TRUSTEE").

          The Company and the Trustee agree as follows for the benefit of each
other and for the equal and ratable benefit of the Holders of the 5 1/2%
Convertible Subordinated Notes due 2008 (the "NOTES"):

                                   ARTICLE 1.
                          DEFINITIONS AND INCORPORATION
                                  BY REFERENCE

SECTION 1.01.     DEFINITIONS.

          "144A GLOBAL NOTE" means a global note substantially in the form of
EXHIBIT A hereto bearing the Global Note Legend and the Private Placement Legend
and deposited with or on behalf of, and registered in the name of, the
Depositary or its nominee that will be issued in a denomination equal to the
outstanding principal amount of the Notes sold in reliance on Rule 144A.

          "ADDITIONAL INTEREST" means all Additional Interest then owing
pursuant to Section 5 of the Registration Rights Agreement.

          "AFFILIATE" of any specified Person means any other Person directly or
indirectly controlling or controlled by or under direct or indirect common
control with such specified Person. For purposes of this definition, "control"
(including, with correlative meanings, the terms "controlling," "controlled by"
and "under common control with"), as used with respect to any Person, shall mean
the possession, directly or indirectly, of the power to direct or cause the
direction of the management or policies of such Person, whether through the
ownership of voting securities, by agreement or otherwise; PROVIDED, HOWEVER,
that beneficial ownership of 10% or more of the voting securities of a Person
shall be deemed to be control.

          "AGENT" means any Registrar, Paying Agent or co-registrar.

          "APPLICABLE PROCEDURES" means, with respect to any transfer or
exchange of or for beneficial interests in any Global Note, the rules and
procedures of the Depositary that apply to such transfer or exchange.

          "BANKRUPTCY LAW" means Title 11, U.S. Code or any similar federal or
state law for the relief of debtors.

          "BOARD OF DIRECTORS" means the Board of Directors of the Company, or
any authorized committee of the Board of Directors.

          "BUSINESS DAY" means any day other than a Legal Holiday.

<Page>

          "CAPITAL LEASE OBLIGATION" means, at the time any determination
thereof is to be made, the amount of the liability in respect of a capital lease
that would at such time be required to be capitalized on a balance sheet in
accordance with GAAP.

          "CAPITAL STOCK" means any and all shares, interests, participations,
rights or other equivalents (however designated) of corporate stock, including,
without limitation, with respect to partnerships, partnership interests (whether
general or limited) and any other interest or participation that confers on a
Person the right to receive a share of the profits and losses of, or
distributions of assets of, such partnership.

          "CLOSING SALE PRICE" means the last reported sales price or, in case
no such reported sale takes place on such date, the average of the reported
closing bid and asked prices in either case on The Nasdaq National Market or, if
the Common Stock is not listed or admitted to trading on The Nasdaq National
Market, on the principal national securities exchange on which the Common Stock
is listed or admitted to trading or, if not listed or admitted to trading on The
Nasdaq National Market or any national securities exchange, the last reported
sales price of the Common Stock as quoted on NASDAQ or, in case no reported
sales takes place, the average of the closing bid and asked prices as quoted on
NASDAQ or any comparable system or, if the Common Stock is not quoted on NASDAQ
or any comparable system, the closing sales price or, in case no reported sale
takes place, the average of the closing bid and asked prices, as furnished by
any two members of the National Association of Securities Dealers, Inc. selected
from time to time by the Company for that purpose.

          "COMPANY" means the issuer, and any and all successors thereto.

          "COMMON STOCK" means the common stock, par value $0.001 per share, of
the Company.

          "CORPORATE TRUST OFFICE OF THE TRUSTEE" shall be at the address of the
Trustee specified in Section 12.02 hereof or such other address as to which the
Trustee may give notice to the Company.

          "CREDIT AGREEMENT" means, collectively, (i) that certain letter
agreement, dated as of March 31, 1999, between the Company and Fleet National
Bank ("Fleet"), as amended by the Loan Modification Agreement, dated as of March
13, 2000 and by the Consent and Second Loan Modification Agreement, dated as of
September 6, 2000, (ii) that certain $1,500,000 face principal amount promissory
note, dated as of March 31, 1000, made by Cubist and payable to the order of
Fleet, (iii) that certain $2,000,000 face principal amount promissory note,
dated as of March 13, 2000, made by the Company and payable to the order of
Fleet, (iv) that certain Security Agreement (Equipment), dated as of March 31,
1000 given by the Company to Fleet, (v) that certain $6,500,000 face principal
amount promissory note, dated as of September 10, 2001, made by the Company and
payable to the order of Fleet, (vi) that certain Third Loan Modification
Agreement, dated as of September 10, 2001, between the Company and Fleet, and
(vii) all modifications, supplements, amendments, replacements and restatements
of those instruments and agreements described in clauses (i) through (vi).

          "CUSTODIAN" means the Trustee, as custodian with respect to the Global
Notes or any successor entity thereto.

<Page>

          "DEFAULT" means any event that is or with the passage of time or the
giving of notice or both would be an Event of Default.

          "DEFINITIVE NOTE" means a certificated Note registered in the name of
the Holder thereof and issued in accordance with Section 2.06 hereof,
substantially in the form of EXHIBIT A hereto except that such Note shall not
bear the Global Note Legend and shall not have the "Schedule of Exchanges of
Interests in the Global Note" attached thereto.

          "DEPOSITARY" means, with respect to any Global Notes, the Person
specified in Section 2.03 hereof as the Depositary with respect to such Global
Notes, and any and all successors thereto appointed as depositary hereunder and
having become such pursuant to the applicable provision of this Indenture.

          "DESIGNATED SENIOR INDEBTEDNESS" means (i) any Indebtedness
outstanding under the Credit Agreement, and (ii) any other Senior Indebtedness
permitted hereunder the principal amount of which is $10.0 million or more, that
has been designated by the Company as "Designated Senior Indebtedness" with the
approval of holders of a majority in principal amount of Designated Senior
Indebtedness, if any.

          "EQUITY INTERESTS" means Capital Stock and all warrants, options or
other rights to acquire Capital Stock (but excluding any debt security that is
convertible into, or exchangeable for, Capital Stock).

          "EXCHANGE ACT" means the Securities Exchange Act of 1934, as amended.

          "GAAP" means generally accepted accounting principles set forth in the
opinions and pronouncements of the Accounting Principles Board of the American
Institute of Certified Public Accountants and statements and pronouncements of
the Financial Accounting Standards Board or in such other statements by such
other entity as have been approved by a significant segment of the accounting
profession, which are in effect on the date of this Indenture.

          "GLOBAL NOTES" means, individually and collectively, each of the
Restricted Global Notes and the Unrestricted Global Notes, substantially in the
form of EXHIBIT A hereto issued in accordance with this Indenture.

          "GLOBAL NOTE LEGEND" means the legend set forth in footnote 1 to
EXHIBIT A hereto, which is required to be placed on all Global Notes issued
under this Indenture.

          "GOVERNMENT SECURITIES" means direct obligations of, or obligations
guaranteed by, the United States of America, and the payment for which the
United States pledges its full faith and credit.

          "HEDGING OBLIGATIONS" means, with respect to any Person, the
obligations of such Person under (i) interest rate swap agreements, interest
rate cap agreements and interest rate collar agreements and (ii) other
agreements or arrangements designed to protect such Person against fluctuations
in interest rates or the value of foreign currencies purchased or received by
the Company in the ordinary course of business.

<Page>

          "HOLDER" means a Person in whose name a Note is registered.

          "INDEBTEDNESS" means, with respect to any Person, without duplication,
(a) all indebtedness, obligations and other liabilities (contingent or
otherwise) of such Person for borrowed money (including obligations of such
Person in respect of overdrafts, foreign exchange contracts, currency exchange
agreements, interest rate protection agreements, and any loans or advances from
banks, whether or not evidenced by notes or similar instruments) or evidenced by
credit or loan agreements, bonds, debentures, notes or other written obligations
(whether or not the recourse of the lender is to the whole of the assets of such
Person or to only a portion thereof) (other than any accounts payable or other
accrued current liability or obligation incurred in the ordinary course of
business in connection with the obtaining of materials or services), (b) all
reimbursement obligations and other liabilities (contingent or otherwise) of
such Person with respect to letters of credit, bank guarantees or bankers'
acceptances, (c) all obligations and liabilities (contingent or otherwise) of
such Person in respect of leases of such Person required, in conformity with
generally accepted accounting principles, to be accounted for as capitalized
lease obligations on the balance sheet of such Person, (d) all obligations of
such Person evidenced by a note or similar instrument given in connection with
the acquisition of any business, properties or assets of any kinds, (e) all
obligations of such Person issued or assumed as the deferred purchase price of
property or services (excluding trade accounts payable and accrued liabilities
arising in the ordinary course of business), (f) all obligations and other
liabilities (contingent or otherwise) of such Person under any lease or related
document (including a purchase agreement) in connection with the lease of real
property or improvements (or any personal property included as part of any such
lease) which provides that such Person is contractually obligated to purchase or
cause a third party to purchase the leased property and thereby guarantee a
minimum residual value of the leased property to the lessor and the obligations
of such Person under such lease or related document to purchase or to cause a
third party to purchase such leased property (whether or not such lease
transaction is characterized as an operating lease or a capitalized lease in
accordance with generally accepted accounting principles), (g) all obligations
(contingent or otherwise) of such Person with respect to any interest rate,
currency or other swap, cap, floor or collar agreement, hedge agreement, forward
contract, or other similar instrument or agreement or foreign currency hedge,
exchange, purchase or similar instrument or agreement, (h) all direct or
indirect guaranties, agreements to be jointly liable or similar agreements by
such Person in respect of, and obligations or liabilities (contingent or
otherwise) of such Person to purchase or otherwise acquire or otherwise assure a
creditor against loss in respect of, indebtedness, obligations or liabilities of
another Person of the kind described in clauses (a) through (g), and (i) any and
all deferrals, renewals, extensions, restatements, replacements and refundings
of, or amendments, modifications, or supplements to, or any indebtedness or
obligation issued in exchange for, any indebtedness, obligation or liability of
the kind described in clauses (a) through (h).

          "INDENTURE" means this Indenture, as amended or supplemented from time
to time.

          "INDIRECT PARTICIPANT" means a Person who holds a beneficial interest
in a Global Note through a Participant.

          "LEGAL HOLIDAY" means a Saturday, a Sunday or a day on which banking
institutions in the City of New York or Wilmington, Delaware or at a place of
payment are authorized by law,

<Page>

regulation or executive order to remain closed. If a payment date is a Legal
Holiday at a place of payment, payment may be made at that place on the next
succeeding day that is not a Legal Holiday, and no interest shall accrue on such
payment for the intervening period.

          "NON-U.S. PERSON" means a Person who is not a U.S. Person.

          "NOTES" has the meaning assigned to it in the preamble to this
Indenture.

          "OBLIGATIONS" means any principal, interest, penalties, fees,
indemnifications, reimbursements, fees and expenses, damages and other
liabilities payable under the documentation governing any Indebtedness.

          "OFFERING" means the offering of the Notes by the Company.

          "OFFICER" means, with respect to any Person, the Chairman of the
Board, the Chief Executive Officer, the President, the Chief Operating Officer,
the Chief Financial Officer, the Treasurer, any Assistant Treasurer, the
Controller, the Secretary or any Vice-President of such Person.

          "OFFICERS' CERTIFICATE" means a certificate signed on behalf of the
Company by two Officers of the Company, one of whom must be the principal
executive officer, the principal financial officer, or the principal accounting
officer of the Company, that meets the requirements of Section 12.05 hereof.

          "OPINION OF COUNSEL" means an opinion from legal counsel who is
reasonably acceptable to the Trustee, that meets the requirements of Section
12.05 hereof. The counsel may be an employee of or counsel to the Company, any
Subsidiary of the Company or the Trustee.

          "PARTICIPANT" means, with respect to the Depositary, a Person who has
an account with the Depositary.

          "PERMITTED JUNIOR SECURITIES" means Equity Interests in the Company or
debt securities that are subordinated to all Senior Indebtedness (and any debt
securities issued in exchange for Senior Indebtedness) to substantially the same
extent as, or to a greater extent than, the Notes are subordinated to Senior
Indebtedness pursuant to the Indenture.

          "PERSON" means any individual, corporation, partnership, limited
liability company, joint venture, association, joint-stock company, trust,
unincorporated organization or government or agency or political subdivision
thereof (including any subdivision or ongoing business of any such entity or
substantially all of the assets of any such entity, subdivision or business).

          "PRIVATE PLACEMENT LEGEND" means the legend set forth in EXHIBIT A
hereto to be placed on all Notes issued under this Indenture except where
otherwise permitted by the provisions of this Indenture.

          "PURCHASE AGREEMENT" means the Purchase Agreement, dated as of October
23, 2001, by and among the Company and Robertson Stephens, Inc., as
representative of the several purchasers.

<Page>

          "QIB" means a "qualified institutional buyer" as defined in Rule 144A.

          "REGISTRATION RIGHTS AGREEMENT" means the Registration Rights
Agreement, dated as of October 26, 2001, by and among the Company and the other
parties named on the signature pages thereof, as such agreement may be amended,
modified or supplemented from time to time.

          "REGULATION S" means Regulation S promulgated under the Securities
Act.

          "REPRESENTATIVE" means the indenture trustee or other trustee, agent
or representative for any Senior Indebtedness.

          "RESPONSIBLE OFFICER," when used with respect to the Trustee, means
any officer within the corporate trust department of the Trustee with direct
responsibilities for the administration of this Indenture and also means, with
respect to a particular corporate trust matter, any other officer to whom such
matter is referred because of his knowledge of and familiarity with the
particular subject.

          "RESTRICTED DEFINITIVE NOTE" means a Definitive Note bearing the
Private Placement Legend.

          "RESTRICTED GLOBAL NOTE" means a Global Note bearing the Private
Placement Legend.

          "RESTRICTED PERIOD" means the 40-day restricted period as defined in
Regulation S.

          "RULE 144" means Rule 144 promulgated under the Securities Act.

          "RULE 144A" means Rule 144A promulgated under the Securities Act.

          "RULE 903" means Rule 903 promulgated under the Securities Act.

          "RULE 904" means Rule 904 promulgated the Securities Act.

          "SEC" means the Securities and Exchange Commission.

          "SECURITIES ACT" means the Securities Act of 1933, as amended.

          "SENIOR INDEBTEDNESS" means (i) the principal of, premium, if any,
interest including all interest accruing subsequent to the commencement of any
bankruptcy or similar proceeding, whether or not a claim for post-petition
interest is allowable as a claim in any such proceeding, and rent payable on or
in connection with Indebtedness of the Company (together with all fees, costs,
expenses, penalties and other amounts accrued or due on or in connection
therewith) unless the instrument under which such Indebtedness is incurred
expressly provides that it is on a parity with or subordinated in right of
payment to the Notes, and (ii) all Obligations with respect to any of the
foregoing, whether secured or unsecured, absolute or contingent, due or to
become due, outstanding on the date hereof or hereafter created, incurred,
assumed, guaranteed or in effect guaranteed by the Company, including all
deferrals, renewals, extensions, replacements and refundings of or amendments,
modifications or supplements to, or any indebtedness or obligation issued in
exchange for, the foregoing. Notwithstanding anything to the contrary in the

<Page>

foregoing, Senior Indebtedness shall not include (x) any Indebtedness of the
Company to any of its Subsidiaries or other Affiliates or, (y) any Indebtedness
incurred for the purchase of goods or materials or for services obtained in the
ordinary course of business (other than with the proceeds of revolving credit
borrowings permitted hereby).

          "SHELF REGISTRATION STATEMENT" means the Shelf Registration Statement
as defined in the Registration Rights Agreement.

          "SUBSIDIARY" means, with respect to any Person, any corporation,
association or other business entity of which more than 50% of the total voting
power of shares of Capital Stock entitled (without regard to the occurrence of
any contingency) to vote in the election of directors, managers or trustees
thereof is at the time owned or controlled, directly or indirectly, by such
Person or one or more of the other Subsidiaries of such Person or a combination
thereof.

          "TIA" means the Trust Indenture Act of 1939 (15 U.S.C. Secctions
77aaa-77bbbb) as in effect on the date on which this Indenture is qualified
under the TIA; PROVIDED, HOWEVER, that in the event the Trust Indenture Act of
1939 is amended after such date, "TIA" means, to the extent required by any such
amendment, the Trust Indenture Act of 1939 as so amended.

          "TRUSTEE" means the party named as such above until a successor
replaces it in accordance with the applicable provisions of this Indenture and
thereafter means the successor serving hereunder.

          "UNRESTRICTED GLOBAL NOTE" means a permanent global Note substantially
in the form of Exhibit A attached hereto that bears the Global Note Legend and
that has the "Schedule of Exchanges of Interests in the Global Note" attached
thereto, and that is deposited with or on behalf of and registered in the name
of the Depositary, representing a series of Notes that do not bear the Private
Placement Legend.

          "UNRESTRICTED DEFINITIVE NOTE" means one or more Definitive Notes that
do not bear and are not required to bear the Private Placement Legend.

          "U.S. PERSON" means a U.S. person as defined in Rule 902(k) under the
Securities Act.

          "VOTING STOCK" of a Person means any class or classes of Capital Stock
pursuant to which the holders of capital stock under ordinary circumstances have
the power to vote in the election of the board of directors, managers or
trustees thereof of such Person or other persons performing similar functions
irrespective of whether or not, at the time Capital Stock of any other class or
classes shall have, or might have, voting power by reason of the happening of
any contingency.

          "WHOLLY OWNED SUBSIDIARY" of any Person means a Subsidiary of such
Person all of the outstanding Capital Stock or other ownership interests of
which (other than directors' qualifying shares) shall at the time be owned by
such Person or by one or more Wholly Owned Subsidiaries of such Person or by
such Person and one or more Wholly Owned Subsidiaries of such Person.

SECTION 1.02.     OTHER DEFINITIONS.

<Page>

<Table>
<Caption>
                                                                      DEFINED IN
    TERM                                                                SECTION

    <S>                                                                  <C>
    "AUTHENTICATION ORDER".............................................  2.02

    "CONVERSION AGENT".................................................  2.03

    "CONVERSION DATE...................................................  4.02

    "CONVERSION PRICE".................................................  4.01

    "DETERMINATION DATE" ..............................................  4.06

    "DTC"..............................................................  2.03

    "EVENT OF DEFAULT".................................................  8.01

    "EXPIRATION DATE" .................................................  4.06

    "EXPIRATION TIME"..................................................  4.06

    "MAKE-WHOLE PAYMENT" ..............................................  3.07

    "NOTICE DATE" .....................................................  3.07

    "PAYING AGENT".....................................................  2.03

    "Payment Blockage Notice"..........................................  5.03

    "PROVISIONAL REDEMPTION" ..........................................  3.07

    "PROVISIONAL REDEMPTION DATE" .....................................  3.07

    "PROVISIONAL REDEMPTION PRICE" ....................................  3.07

    "PURCHASED SHARES" ................................................  4.06

    "REGISTRAR"........................................................  2.03

    "REPURCHASE EVENT" ................................................  6.09

    "REPURCHASE EVENT OFFER"...........................................  6.09

    "REPURCHASE EVENT PAYMENT".........................................  6.09

    "REPURCHASE EVENT PAYMENT DATE"....................................  6.09

    "REPURCHASE EVENT PAYMENT NOTICE" .................................  6.09
</Table>

<Page>

<Table>
    <S>                                                                  <C>
    "TENDER OFFER" ....................................................  4.06

    "TENDER PURCHASED SHARES"..........................................  4.06

    "TENDER EXPIRATION TIME"...........................................  4.06

    "TRIGGERING DISTRIBUTION"..........................................  4.06
</Table>

SECTION 1.03.     INCORPORATION BY REFERENCE OF TRUST INDENTURE ACT.

          Whenever this Indenture refers to a provision of the TIA, the
provision is incorporated by reference in and made a part of this Indenture.

          The following TIA terms used in this Indenture have the following
meanings:

          "INDENTURE SECURITIES" means the Notes;

          "INDENTURE SECURITY HOLDER" means a Holder of a Note;

          "INDENTURE TO BE QUALIFIED" means this Indenture;

          "INDENTURE TRUSTEE" or "INSTITUTIONAL TRUSTEE" means the Trustee; and

          "OBLIGOR" on the Notes means the Company and any successor obligor
upon the Notes.

          All other terms used in this Indenture that are defined by the TIA,
defined by TIA reference to another statute or defined by SEC rule under the TIA
have the meanings so assigned to them.

SECTION 1.04.     RULES OF CONSTRUCTION.

          Unless the context otherwise requires:

          (a) a term has the meaning assigned to it;

          (b) an accounting term not otherwise defined has the meaning assigned
to it in accordance with GAAP;

          (c) "or" is not exclusive;

          (d) words in the singular include the plural, and in the plural
include the singular;

          (e) provisions apply to successive events and transactions; and

          (f) references to sections of or rules under the Securities Act shall
be deemed to include substitute, replacement of successor sections or rules
adopted by the SEC from time to time.

<Page>

                                   ARTICLE 2.
                                    THE NOTES

SECTION 2.01.     FORM AND DATING

          (a) GENERAL. The Notes and the Trustee's certificate of authentication
shall be substantially in the form of EXHIBIT A hereto. The Notes may have
notations, legends or endorsements required by law, stock exchange rule or
usage. Each Note shall be dated the date of its authentication. The Notes shall
be in denominations of $1,000 and integral multiples thereof. The terms and
provisions contained in the Notes shall constitute, and are hereby expressly
made, a part of this Indenture and the Company and the Trustee, by their
execution and delivery of this Indenture, expressly agree to such terms and
provisions and to be bound thereby. However, to the extent any provision of any
Note conflicts with the express provisions of this Indenture, the provisions of
this Indenture shall govern and be controlling.

          (b) GLOBAL NOTES. Notes issued in global form shall be substantially
in the form of EXHIBIT A attached hereto (including the Global Note Legend
thereon and the "Schedule of Exchanges of Interests in the Global Note" attached
thereto). Notes issued in definitive form shall be substantially in the form of
EXHIBIt A attached hereto (but without the Global Note Legend thereon and
without the "Schedule of Exchanges of Interests in the Global Note" attached
thereto). Each Global Note shall represent such of the outstanding Notes as
shall be specified therein and each shall provide that it shall represent the
aggregate principal amount of outstanding Notes from time to time endorsed
thereon and that the aggregate principal amount of outstanding Notes represented
thereby may from time to time be reduced or increased, as appropriate, to
reflect exchanges and redemptions. Any endorsement of a Global Note to reflect
the amount of any increase or decrease in the aggregate principal amount of
outstanding Notes represented thereby shall be made by the Trustee or the
Custodian, at the direction of the Trustee, in accordance with instructions
given by the Holder thereof as required by Section 2.12 hereof.

SECTION 2.02.     EXECUTION AND AUTHENTICATION.

          An Officer shall sign the Notes for the Company by manual or facsimile
signature. The Company's seal shall be reproduced on the Notes and may be in
facsimile form.

          If an Officer whose signature is on a Note no longer holds that office
at the time a Note is authenticated, the Note shall nevertheless be valid.

         A Note shall not be valid until authenticated by the manual signature
of the Trustee. The signature shall be conclusive evidence that the Note has
been authenticated under this Indenture.

          The Trustee shall, upon a written order of the Company signed by an
Officer (an "AUTHENTICATION ORDER"), authenticate Notes for original issue in
the aggregate principal amount of up to $175,000,000. The Authentication Order
shall specify the amount of Notes to be authenticated, shall provide that all
Notes will be represented by a Restricted Global Note and the date on which each
original issue of Notes is to be authenticated. The aggregate principal amount
of Notes outstanding at any time may not exceed $175,000,000 (taking into
account the

<Page>

45-day option granted to the initial purchasers of the Notes to purchase up to
an additional $50,000,000 in aggregate principal amount of Notes) except as
provided in Section 2.07 hereof.

          The Trustee shall act as initial authenticating agent. Thereafter, the
Trustee may appoint an authenticating agent acceptable to the Company to
authenticate Notes. An authenticating agent may authenticate Notes whenever the
Trustee may do so. Each reference in this Indenture to authentication by the
Trustee includes authentication by such agent. An authenticating agent has the
same rights as an Agent to deal with the Company or an Affiliate of the Company.

SECTION 2.03.     REGISTRAR, PAYING AGENT AND CONVERSION AGENT.

          The Company shall maintain an office or agency where Notes may be
presented for registration of transfer or for exchange ("REGISTRAR"), an office
or agency where Notes may be presented for payment ("PAYING AGENT"), an office
or agency where Notes may be presented for conversion ("CONVERSION AGENT") and
an office or agent where notices and demands to or upon the Company in respect
of the Notes and this Indenture may be served. The Registrar shall keep a
register of the Notes and of their registration of transfer and exchange. The
Company may appoint one or more co-registrars and one or more additional paying
agents and conversion agents. The term "Registrar" includes any co-registrar,
the term "Paying Agent" includes any additional paying agent and the term
"Conversion Agent" includes any additional conversion agent. The Company may
change any Paying Agent, Conversion Agent or Registrar without notice to any
Holder. The Company shall notify the Trustee in writing of the name and address
of any Agent not a party to this Indenture. If the Company fails to appoint or
maintain another entity as Registrar, Paying Agent, Conversion Agent or agent
for service of notices and demands in any place required by this Indenture, or
fails to give the foregoing notice, the Trustee shall act as such. The Company
or any of its Subsidiaries may act as Paying Agent, Conversion Agent or
Registrar.

          The Company initially appoints The Depository Trust Company ("DTC") to
act as Depositary with respect to the Global Notes.

          The Company initially appoints the Trustee to act as the Registrar,
Paying Agent and Conversion Agent and to act as Custodian with respect to the
Global Notes.

SECTION 2.04.     PAYING AGENT TO HOLD MONEY IN TRUST.

          Prior to 10:00 a.m., New York City time, on each due date of the
principal of, premium, if any, or interest (including Additional Interest), on
any Notes, the Company shall deposit with the Paying Agent a sum sufficient to
pay such principal, premium, if any, or interest so becoming due. The Company
shall require each Paying Agent other than the Trustee to agree in writing that
the Paying Agent will hold in trust for the benefit of Holders or the Trustee
all money held by the Paying Agent for the payment of principal, premium or
Additional Interest, if any, or interest on the Notes, and will notify the
Trustee of any default by the Company in making any such payment. While any such
default continues, the Trustee may require a Paying Agent to pay all money held
by it to the Trustee. The Company at any time may require a Paying Agent to pay
all money held by it to the Trustee. Upon payment over to the Trustee, the
Paying Agent (if other than the Company or a Subsidiary) shall have no further
liability for the money. If the

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Company or a Subsidiary acts as Paying Agent, it shall before 10:00 a.m., New
York City time, on each due date of the principal of, premium, if any, or
interest (including Additional Interest), segregate and hold in a separate trust
fund for the benefit of the Holders all money held by it as Paying Agent. Upon
any bankruptcy or reorganization proceedings relating to the Company, the
Trustee shall serve as Paying Agent for the Notes.

SECTION 2.05.     HOLDER LISTS.

          The Trustee shall preserve in as current a form as is reasonably
practicable the most recent list available to it of the names and addresses of
all Holders and shall otherwise comply with TIA Section 312(a). If the Trustee
is not the  Registrar,  the Company  shall furnish to the Trustee at least seven
Business Days before each  interest  payment date and at such other times as the
Trustee may  request in writing,  a list in such form and as of such date as the
Trustee  may  reasonably  require of the names and  addresses  of the Holders of
Notes and the Company shall otherwise comply with TIA Section 312(a).

SECTION 2.06.     TRANSFER AND EXCHANGE.

          (a) Subject to compliance with any applicable additional requirements
contained in Section 2.12, when a Note is presented to a Registrar with a
request to register a transfer thereof or to exchange such Note for an equal
principal amount of Notes of other authorized denominations, the Registrar shall
register the transfer or make the exchange as requested; PROVIDED, HOWEVER, that
every Note presented or surrendered for registration of transfer or exchange
shall be duly endorsed or accompanied by an assignment form and, if applicable,
a transfer certificate each in the form included in EXHIBIT A, and in form
satisfactory to the Registrar duly executed by the Holder thereof or its
attorney duly authorized in writing. To permit registration of transfers and
exchanges, upon surrender of any Note for registration of transfer or exchange
at an office or agency maintained pursuant to Section 2.03, the Company shall
execute and the Trustee shall authenticate Notes of a like aggregate principal
amount at the Registrar's request. Any exchange or registration of transfer
shall be without charge, except that the Company or the Registrar may require
payment of a sum sufficient to cover any tax or other governmental charge that
may be imposed in relation thereto, and provided, that this sentence shall not
apply to any exchange pursuant to Section 2.07, 2.10, 2.12(a), 3.06, 6.09(a)(7),
4.02 (last paragraph) or 11.05.

          Neither the Company, any Registrar nor the Trustee shall be required
to exchange or register a transfer of (a) any Notes for a period of 15 days next
preceding any mailing of a notice of Notes to be redeemed, (b) any Notes or
portions thereof selected or called for redemption (except, in the case of
redemption of a Note in part, the portion not to be redeemed) or (c) any Notes
or portions thereof in respect of which a Note has been delivered and not
withdrawn by the Holder thereof (except, in the case of the purchase of a Note
in part, the portion not to be purchased).

          All Notes issued upon any registration of transfer or exchange of
Notes shall be valid obligations of the Company, evidencing the same debt and
entitled to the same benefits under this Indenture, as the Notes surrendered
upon such registration of transfer or exchange.

<Page>

          (b) Any Registrar appointed pursuant to Section 2.03 hereof shall
provide to the Trustee such information as the Trustee may reasonably require in
connection with the delivery by such Registrar of Notes upon registration of
transfer or exchange of Notes.

          (c) Each Holder of a Note agrees to indemnify the Company, the
Registrar and the Trustee against any liability that may result from the
registration of transfer, exchange or assignment of such Holder's Note in
violation of any provision of this Indenture and/or applicable United States
federal or state securities law.

          The Trustee shall have no obligation or duty to monitor, determine or
inquire as to compliance with any restrictions on registration of transfer
imposed under this Indenture or under applicable law with respect to any
transfer of any interest in any Note (including any transfers between or among
Participants or other beneficial owners of interests in any Global Note) other
than to require delivery of such certificates and other documentation or
evidence as are expressly required by, and to do so if and when expressly
required by the terms of, this Indenture, and to examine the same to determine
substantial compliance as to form with the express requirements hereof.

SECTION 2.07.     REPLACEMENT NOTES.

          If any mutilated Note is surrendered to the Trustee or the Company and
the Trustee receives evidence to its satisfaction of the destruction, loss or
theft of any Note, the Company shall issue and the Trustee, upon receipt of an
Authentication Order, shall authenticate a replacement Note if the Trustee's
requirements are met. An indemnity bond must be supplied by the Holder that is
sufficient in the judgment of the Trustee and the Company to protect the
Company, the Trustee, any Agent and any authenticating agent from any loss that
any of them may suffer if a Note is replaced. The Company may charge for its
expenses in replacing a Note.

          Every replacement Note is an additional obligation of the Company and
shall be entitled to all of the benefits of this Indenture equally and
proportionately with all other Notes duly issued hereunder.

SECTION 2.08.     OUTSTANDING NOTES.

          The Notes outstanding at any time are all the Notes authenticated by
the Trustee except for those canceled by it, those delivered to it for
cancellation, those reductions in the interest in a Global Note effected by the
Trustee in accordance with the provisions hereof, and those described in this
Section as not outstanding. Except as set forth in Section 2.09 hereof, a Note
does not cease to be outstanding because the Company or an Affiliate of the
Company holds the Note.

          If a Note is replaced pursuant to Section 2.07 hereof, it ceases to be
outstanding unless the Trustee receives proof satisfactory to it that the
replaced Note is held by a protected purchaser.

          If the principal amount of any Note is considered paid under Section
6.01 hereof, it ceases to be outstanding and interest on it ceases to accrue.

<Page>

          If the Paying Agent (other than the Company, a Subsidiary or an
Affiliate of any thereof) holds, on a redemption date, a Repurchase Event
Payment Date or maturity date, money sufficient to pay Notes payable on that
date, then on and after that date such Notes shall be deemed to be no longer
outstanding and shall cease to accrue interest.

SECTION 2.09.     TREASURY NOTES.

          In determining whether the Holders of the required principal amount of
Notes have concurred in any notice, direction, waiver or consent, Notes owned by
the Company, or by any Person directly or indirectly controlling or controlled
by or under direct or indirect common control with the Company, shall be
considered as though not outstanding, except that for the purposes of
determining whether the Trustee shall be protected in relying on any such
notice, direction, waiver or consent, only Notes that a Responsible Officer of
the Trustee actually knows are so owned shall be so disregarded.

SECTION 2.10.     TEMPORARY NOTES.

          Until certificates representing Notes are ready for delivery, the
Company may prepare and execute, and the Trustee, upon receipt of an
Authentication Order, shall authenticate and deliver temporary Notes. Temporary
Notes shall be substantially in the form of definitive Notes but may have
variations that the Company considers appropriate for temporary Notes and as
shall be reasonably acceptable to the Trustee. Without unreasonable delay, the
Company shall prepare and the Trustee, upon receipt of an Authentication Order,
shall authenticate and deliver definitive Notes in exchange for temporary Notes.

          Holders of temporary Notes shall be entitled to all of the benefits of
this Indenture.

SECTION 2.11.     CANCELLATION.

          The Company at any time may deliver Notes to the Trustee for
cancellation. The Registrar, Paying Agent and Conversion Agent shall forward to
the Trustee any Notes surrendered to them for registration of transfer,
exchange, redemption, payment or conversion. The Trustee and no one else shall
cancel all Notes surrendered for registration of transfer, exchange, redemption,
payment, conversion, replacement or cancellation and shall dispose of canceled
Notes (subject to the record retention requirement of the Exchange Act), in
accordance with its normal procedures. All Notes which are redeemed, purchased
or otherwise acquired by the Company or any of its Subsidiaries prior to the
maturity date shall be delivered to the Trustee for cancellation. The Company
may not hold or resell such Notes or issue new Notes to replace Notes that it
has purchase or otherwise acquired or that have been delivered to the Trustee
for cancellation.

SECTION 2.12.     ADDITIONAL TRANSFER AND EXCHANGE REQUIREMENTS.

         (a)      TRANSFER AND EXCHANGE OF GLOBAL NOTES.

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                  (1) Definitive Notes shall be issued in exchange for interests
          in the Global  Notes only (x) if the  Depositary  notifies the Company
          that it is  unwilling  or unable to  continue  as  depositary  for the
          Global  Notes or if it at any time  ceases to be a  "clearing  agency"
          registered under the Exchange Act, if so required by applicable law or
          regulation and a successor  depositary is not appointed by the Company
          within  90 days;  (y) if an  Event  of  Default  has  occurred  and is
          continuing;  or (z) upon the  written  request to the  Trustee and the
          Custodian, in accordance with the standing instructions and procedures
          existing between the Depositary and the Custodian,  by any QIB that is
          a  beneficial  holder of an interest in the Global  Note.  In any such
          case, the Company shall execute,  and the Trustee shall,  upon receipt
          of an  Authentication  Order  (which  the  Company  agrees to  deliver
          promptly),  authenticate and deliver  Definitive Notes in an aggregate
          principal amount equal to the principal amount of such Global Notes in
          exchange therefor. Only Restricted Definitive Notes shall be issued in
          exchange for beneficial interests in Restricted Global Notes, and only
          Unrestricted   Definitive  Notes  shall  be  issued  in  exchange  for
          beneficial  interests in Unrestricted  Global Notes.  Definitive Notes
          issued in exchange for  beneficial  interests in Global Notes shall be
          registered in such names and shall be in such authorized denominations
          as the  Depositary,  pursuant  to  instructions  from  its  direct  or
          indirect  participants or otherwise,  shall instruct the Trustee.  The
          Trustee shall deliver or cause to be delivered such  Definitive  Notes
          to the  persons  in whose  names such  Notes are so  registered.  Such
          exchange   shall  be  effected  in  accordance   with  the  Applicable
          Procedures.

                  (2)  Notwithstanding  any other  provisions of this  Indenture
          other than the  provisions set forth in Section  2.12(a)(1),  a Global
          Note may not be  transferred  as a whole except by the Depositary to a
          nominee of the  Depositary  or by a nominee of the  Depositary  to the
          Depositary or another  nominee of the  Depositary or by the Depositary
          or any such  nominee to a  successor  Depositary  or a nominee of such
          successor Depositary.

          (b) TRANSFER AND EXCHANGE OF DEFINITIVE NOTES. In the event that
Definitive Notes are issued in exchange for beneficial interests in Global Notes
in accordance with Section 2.12(a)(1) of this Indenture, on or after such event
when Definitive Notes are presented by a Holder to a Registrar with a request:

                  (x)     to register the transfer of the Definitive Notes to a
          person who will take delivery thereof in the form of Definitive Notes
          only; or

                  (y)     to exchange such Definitive Notes for an equal
          principal amount of Definitive Notes of other authorized
          denominations,

          such Registrar shall register the transfer or make the exchange as
requested; PROVIDED, HOWEVER, that the Definitive Notes presented or
surrendered for register of transfer or exchange:

                  (1)     shall be duly endorsed or accompanied by a written
          instrument of transfer in accordance with the proviso to the first
          paragraph of Section 2.06(a); and

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                  (2)     in the case of a Restricted Definitive Note, such
          request shall be accompanied by the following additional information
           and documents, as applicable:

                          (i)     if such Restricted Definitive Note is being
                  delivered to the Registrar by a Holder for registration in the
                  name of such Holder, without transfer, or such Restricted
                  Definitive Note is being transferred to the Company or a
                  Subsidiary of the Company, a certification to that effect from
                  such Holder (in substantially the form set forth in the
                  Transfer Certificate);

                          (ii)    if such Restricted Definitive Note is being
                  transferred to a person the Holder reasonably believes is a
                  QIB in accordance with Rule 144A or is being transferred to a
                  Non-U.S. Person in an offshore transaction in accordance with
                  Rule 903 or Rule 904 or pursuant to an effective registration
                  statement under the Securities Act, a certification to that
                  effect from such Holder (in substantially the form set forth
                  in the Transfer Certificate); or

                          (iii)   if such Restricted Definitive Note is being
                  transferred (A) pursuant to an exemption from the registration
                  requirements of the Securities Act in accordance with Rule 144
                  or (B) pursuant to an exemption from the registration
                  requirements of the Securities Act (other than pursuant to
                  Rule 144A, Rule 144, Rule 903 or Rule 904) and as a result of
                  which, in the case of a Note transferred pursuant to this
                  clause (B), such Note shall cease to be a "restricted
                  security" within the meaning of Rule 144, a certification to
                  that effect from the Holder (in substantially the form set
                  forth in the Transfer Certificate) and, if the Company or such
                  Registrar so requests, a customary opinion of counsel,
                  certificates and other information reasonably acceptable to
                  the Company and such Registrar to the effect that such
                  transfer is in compliance with the registration requirements
                  of the Securities Act.

          (c)     TRANSFER OF A BENEFICIAL INTEREST IN A RESTRICTED GLOBAL NOTE
FOR A BENEFICIAL INTEREST IN AN UNRESTRICTED GLOBAL NOTE. Any person having a
beneficial interest in a Restricted Global Note may upon request, subject to the
Applicable Procedures, transfer such beneficial interest to a person who is
required or permitted to take delivery thereof in the form of a beneficial
interest in an Unrestricted Global Note. Upon receipt by the Trustee of written
instructions, or such other form of instructions as is customary for the
Depositary, from the Depositary or its nominee on behalf of any person having a
beneficial interest in a Restricted Global Note and the following additional
information and documents in such form as is customary for the Depositary from
the Depositary or its nominee on behalf of the person having such beneficial
interest in the Restricted Global Note (all of which may be submitted by
facsimile or electronically):

                  (1)     if such beneficial interest is being transferred
          pursuant to an effective registration statement under the Securities
          Act, a certification to that effect from the transferor (in
          substantially the form set forth in the Transfer Certificate); or

                  (2)     if such beneficial interest is being transferred (i)
          pursuant to an exemption from the registration requirements of the
          Securities Act in accordance with Rule 144 or

<Page>

          (ii) pursuant to an exemption from the registration requirements of
          the Securities Act (other than pursuant to Rule 144A, Rule 144, Rule
          903 or Rule 904) and as a result of which, in the case of a Note
          transferred pursuant to this clause (ii), such Note shall cease to be
          a "restricted security" within the meaning of Rule 144, a
          certification to that effect from the transferor (in substantially the
          form set forth in the Transfer Certificate) and, if the Company or the
          Trustee so requests, a customary opinion of counsel, certificates and
          other information reasonably acceptable to the Company and the Trustee
          to the effect that such transfer is in compliance with the
          registration requirements of the Securities Act.

          The Trustee, as a Registrar and Custodian, shall reduce or cause to be
reduced the aggregate principal amount of the Restricted Global Note by the
appropriate principal amount and shall increase or cause to be increased the
aggregate principal amount of the Unrestricted Global Note by a like principal
amount. Such transfer shall otherwise be effected in accordance with the
Applicable Procedures. If no Unrestricted Global Note is then outstanding, the
Company shall execute and the Trustee shall, upon receipt of an Authentication
Order (which the Company agrees to deliver promptly), authenticate and deliver
an Unrestricted Global Note.

          (d) TRANSFER OF A BENEFICIAL INTEREST IN AN UNRESTRICTED GLOBAL NOTE
FOR A BENEFICIAL INTEREST IN A RESTRICTED GLOBAL NOTE. Any person having a
beneficial interest in an Unrestricted Global Note may upon request, subject to
the Applicable Procedures, transfer such beneficial interest to a person who is
required or permitted to take delivery thereof in the form of a Restricted
Global Note (it being understood that only QIBs may own beneficial interests in
Restricted Global Notes). Upon receipt by the Trustee of written instructions or
such other form of instructions as is customary for the Depositary, from the
Depositary or its nominee, on behalf of any person having a beneficial interest
in an Unrestricted Global Note and, in such form as is customary for the
Depositary, from the Depositary or its nominee on behalf of the person having
such beneficial interest in the Unrestricted Global Note (all of which may be
submitted by facsimile or electronically) a certification from the transferor
(in substantially the form set forth in the Transfer Certificate) to the effect
that such beneficial interest is being transferred to a person that the
transferor reasonably believes is a QIB in accordance with Rule 144A. The
Trustee, as a Registrar and Custodian, shall reduce or cause to be reduced the
aggregate principal amount of the Unrestricted Global Note by the appropriate
principal amount and shall increase or cause to be increased the aggregate
principal amount of the Restricted Global Note by a like principal amount. Such
transfer shall otherwise be effected in accordance with the Applicable
Procedures. If no Restricted Global Note is then outstanding, the Company shall
execute and the Trustee shall, upon receipt of an Authentication Order (which
the Company agrees to deliver promptly), authenticate and deliver a Restricted
Global Note.

          (e) TRANSFERS OF DEFINITIVE NOTES FOR BENEFICIAL INTEREST IN GLOBAL
NOTES . In the event that Definitive Notes are issued in exchange for beneficial
interests in Global Notes and, thereafter, the events or conditions specified in
Section 2.12(a)(1) which required such exchange shall cease to exist, the
Company shall mail notice to the Trustee and to the Holders stating that Holders
may exchange Definitive Notes for interests in Global Notes by complying with
the procedures set forth in this Indenture and briefly describing such
procedures and the events or circumstances requiring that such notice be given.
Thereafter, if Definitive Notes are presented by a Holder to a Registrar with a
request:

<Page>

                  (x) to register the transfer of such Definitive Notes to a
          person who will take delivery thereof in the form of a beneficial
          interest in a Global Note, which request shall specify whether such
          Global Note will be a Restricted Global Note or an Unrestricted Global
          Note; or

                  (y)     to exchange such Definitive Notes for an equal
          principal amount of beneficial interests in a Global Note, which
          beneficial interests will be owned by the Holder transferring such
          Definitive Notes (provided that in the case of such an exchange,
          Restricted Definitive Notes may be exchanged only for Restricted
          Global Notes and Unrestricted Definitive Notes may be exchanged only
          for Unrestricted Global Notes),

          the Registrar shall register the transfer or make the exchange as
requested by canceling such Definitive Note and causing, or directing the
Custodian to cause, the aggregate principal amount of the applicable Global Note
to be increased accordingly and, if no such Global Note is then outstanding, the
Company shall issue and the Trustee, upon receipt of an Authentication Order,
shall authenticate and deliver a new Global Note; PROVIDED, HOWEVER, that the
Definitive Notes presented or surrendered for registration of transfer or
exchange:

                  (1)     shall be duly endorsed or accompanied by a written
          instrument of transfer in accordance with the proviso to Section 2.06;

                  (2)     in the case of a Restricted Definitive Note to be
          transferred for a beneficial interest in an Unrestricted Global Note,
          such request shall be accompanied by the following additional
          information and documents, as applicable:

                          (i)     if such Restricted Definitive Note is being
                  transferred pursuant to an effective registration statement
                  under the Securities Act, a certification to that effect from
                  such Holder (in substantially the form set forth in the
                  Transfer Certificate); or

                          (ii)    if such Restricted Definitive Note is being
                  transferred pursuant to (A) an exemption from the registration
                  requirements of the Securities Act in accordance with Rule 144
                  or (B) pursuant to an exemption from the registration
                  requirements of the Securities Act (other than pursuant to
                  Rule 144A, Rule 144, Rule 903 or Rule 904) and as a result of
                  which, in the case of a Note transferred pursuant to this
                  clause (B), such Note shall cease to be a "restricted
                  security" within the meaning of Rule 144, a certification to
                  that effect from such Holder (in substantially the form set
                  forth in the Transfer Certificate), and, if the Company or the
                  Registrar so requests, a customary opinion of counsel,
                  certificates and other information reasonably acceptable to
                  the Company and the Trustee to the effect that such transfer
                  is in compliance with the registration requirements of the
                  Securities Act;

                  (3)     in the case of a Restricted Definitive Note to be
          transferred or exchanged for a beneficial interest in a Restricted
          Global Note, such request shall be accompanied by a certification from
          such Holder (in substantially the form set forth in the Transfer
          Certificate) to the effect that such Restricted Definitive Note is
          being transferred to a

<Page>

          person the Holder reasonably believes is a QIB (which, in the case of
          an exchange, shall be such Holder) in accordance with Rule 144A or is
          being transferred to a Non-U.S. Person in an offshore transaction in
          accordance with Rule 903 or Rule 904;

                  (4)     in the case of an Unrestricted Definitive Note to be
          transferred or exchanged for a beneficial interest in an Unrestricted
          Global Note, such request need not be accompanied by any additional
          information or documents; and

                  (5)     in the case of an Unrestricted Definitive Note to be
          transferred or exchanged for a beneficial interest in a Restricted
          Global Note, such request shall be accompanied by a certification from
          such Holder (in substantially the form set forth in the Transfer
          Certificate) to the effect that such Unrestricted Definitive Note is
          being transferred to a person the Holder reasonably believes is a QIB
          (which, in the case of an exchange, shall be such Holder) in
          accordance with Rule 144A or is being transferred to a Non-U.S. Person
          in an offshore transaction in accordance with Rule 903 or Rule 904.

          (f)     LEGENDS.

                  (1)     Except as permitted by the following paragraphs (2)
          and (3), each Global Note and Definitive Note (and all Notes issued in
          exchange therefor or upon registration of transfer or replacement
          thereof) shall bear a legend in substantially the form called for
          EXHIBIT A hereto (each a "Restricted Global Note" for so long as it is
          required by this Indenture to bear such legend). Each Restricted
          Global Note shall have attached thereto a certificate (a "Transfer
          Certificate") in substantially the form called for by EXHIBIT A
          hereto.

                  (2)     Upon any sale or transfer of a Restricted Global Note
          (w) after the expiration of the holding period applicable to sales of
          the Notes under Rule 144(k) of the Notes Act, (x) pursuant to Rule
          144, (y) pursuant to an effective registration statement under the
          Notes Act or (z) pursuant to any other available exemption (other than
          Rule 144A) from the registration requirements of the Securities Act
          and as a result of which, in the case of a Note transferred pursuant
          to this clause (z), such Note shall cease to be a "restricted
          security" within the meaning of Rule 144:

                          (i)     in the case of any Restricted Definitive Note,
                  any Registrar shall permit the Holder thereof to exchange such
                  Restricted Definitive Note for an Unrestricted Definitive
                  Note, or (under the circumstances described in Section
                  2.12(e)) to transfer such Restricted Definitive Note to a
                  transferee who shall take such Note in the form of a
                  beneficial interest in an Unrestricted Global Note, and in
                  each case shall rescind any restriction on the transfer of
                  such Note; PROVIDED, HOWEVER, that the Holder of such
                  Restricted Definitive Note shall, in connection with such
                  exchange or transfer, comply with the other applicable
                  provisions of this Section 2.12; and

                          (ii)    in the case of any beneficial interest in a
                  Restricted Global Note, the Trustee shall permit the
                  beneficial owner thereof to transfer such beneficial interest
                  to a transferee who shall take such interest in the form of a
                  beneficial interest in an Unrestricted Global Note and shall
                  rescind any restriction on transfer of such beneficial

<Page>

                  interest; provided, that such Unrestricted Global Note shall
                  continue to be subject to the provisions of Section
                  2.12(a)(2); and provided, further, that the owner of such
                  beneficial interest shall, in connection with such transfer,
                  comply with the other applicable provisions of this Section
                  2.12.

                  (3)     Upon the exchange, registration of transfer or
          replacement of Notes not bearing the legend described in paragraph (1)
          above, the Company shall execute, and the Trustee shall authenticate
          and deliver Notes that do not bear such legend and that do not have a
          Transfer Certificate attached thereto.

                  (4)     After the expiration of the holding period pursuant to
          Rule 144(k) of the Securities Act, the Company may with the consent of
          the Holder of a Restricted Global Note or Restricted Definitive Note,
          remove any restriction of transfer on such Note, and the Company shall
          execute, and the Trustee shall authenticate and deliver Notes that do
          not bear such legend and that do not have a Transfer Certificate
          attached thereto.

          (g)     TRANSFERS TO THE COMPANY. Nothing in this Indenture or in the
Notes shall prohibit the sale or other transfer of any Notes (including
beneficial interests in Global Notes) to the Company or any of its Subsidiaries,
which Notes shall thereupon be cancelled in accordance with Section 2.11.

SECTION 2.13.     CUSIP NUMBERS.

         The Company in issuing the Notes may use "CUSIP" numbers (if then
generally in use), and, if so, the Trustee shall use "CUSIP" numbers in notices
of redemption or purchase as a convenience to Holders; provided that any such
notice may state that no representation is made as to the correctness of such
numbers either as printed on the Notes or as contained in any notice of a
redemption or purchase and that reliance may be placed only on the other
identification numbers printed on the Notes, and any such redemption or purchase
shall not be affected by any defect in or omission of such numbers. The Company
will promptly notify the Trustee of any change in the "CUSIP" numbers.

SECTION 2.14.     DEFAULTED INTEREST.

          If the Company defaults in a payment of interest on the Notes, it
shall pay the defaulted interest in any lawful manner plus, to the extent
lawful, interest payable on the defaulted interest, to the Persons who are
Holders on a subsequent special record date, in each case at the rate provided
in the Notes and in Section 4.01 hereof. The Company shall notify the Trustee in
writing of the amount of defaulted interest proposed to be paid on each Note and
the date of the proposed payment. The Company shall fix or cause to be fixed
each such special record date and payment date, PROVIDED that no such special
record date shall be less than 10 days prior to the related payment date for
such defaulted interest. At least 15 days before the special record date, the
Company (or, upon the written request of the Company, the Trustee in the name
and at the expense of the Company) shall mail or cause to be mailed to Holders a
notice that states the special record date, the related payment date and the
amount of such interest to be paid.

<Page>

                                   ARTICLE 3.
                            REDEMPTION AND PREPAYMENT

SECTION 3.01.     NOTICES TO TRUSTEE.

          If the Company elects to redeem Notes pursuant to the provisional or
optional redemption provisions of Section 3.07 hereof, it shall furnish to the
Trustee, at least 35 days but not more than 60 days before a redemption date, an
Officers' Certificate setting forth (i) the clause of this Indenture pursuant to
which the redemption shall occur, (ii) the redemption date, (iii) the principal
amount of Notes to be redeemed and (iv) the redemption price.

SECTION 3.02.     SELECTION OF NOTES TO BE REDEEMED.

          If less than all of the Notes are to be redeemed or purchased in an
offer to purchase at any time, the Trustee shall select the Notes to be redeemed
or purchased among the Holders of the Notes in compliance with the requirements
of the principal national securities exchange, if any, on which the Notes are
listed or, if the Notes are not so listed, on a PRO RATA basis, by lot or in
accordance with any other method the Trustee considers fair and appropriate. In
the event of partial redemption by lot, the particular Notes to be redeemed
shall be selected, unless otherwise provided herein, not less than 20 nor more
than 60 days prior to the redemption date by the Trustee from the outstanding
Notes not previously called for redemption.

          The Trustee shall promptly notify the Company in writing of the Notes
selected for redemption and, in the case of any Note selected for partial
redemption, the principal amount thereof to be redeemed. Notes and portions of
Notes selected shall be in amounts of $1,000 or whole multiples of $1,000;
except that if all of the Notes of a Holder are to be redeemed, the entire
outstanding amount of Notes held by such Holder, even if not a multiple of
$1,000, shall be redeemed. Except as provided in the preceding sentence,
provisions of this Indenture that apply to Notes called for redemption also
apply to portions of Notes called for redemption.

SECTION 3.03.     NOTICE OF REDEMPTION.

          At least 20 days but not more than 60 days before a redemption date,
the Company shall mail or cause to be mailed, by first class mail, a notice of
redemption to each Holder whose Notes are to be redeemed at its registered
address.

          The notice shall identify the Notes (including CUSIP numbers) to be
redeemed and shall state:

          (a)     the redemption date;

          (b)     the redemption price;

          (c)     the then current Conversion Price;

<Page>

          (d)     if any Note is being redeemed in part, the portion of the
principal amount of such Note to be redeemed and that, after the redemption date
upon surrender of such Note, a new Note or Notes in principal amount equal to
the unredeemed portion shall be issued upon cancellation of the original Note;

          (e)     the name and address of the Paying Agent and Conversion Agent;

          (f)     that Notes called for redemption must be surrendered to the
Paying Agent to collect the redemption price;

          (g)     that Holders who wish to convert Notes must surrender such
Notes for conversion no later than the close of business on the Business Day
immediately preceding the redemption date and must satisfy the other
requirements of the Notes;

          (h)     that, unless the Company defaults in making such redemption
payment, interest on Notes called for redemption ceases to accrue on and after
the redemption date;

          (i)     the paragraph of the Notes and/or Section of this Indenture
pursuant to which the Notes called for redemption are being redeemed; and

          (j)     that no representation is made as to the correctness or
accuracy of the CUSIP number, if any, listed in such notice or printed on the
Notes.

          At the Company's request, the Trustee shall give the notice of
redemption in the Company's name and at its expense; PROVIDED, HOWEVER, that the
Company shall have delivered to the Trustee, at least 35 days prior to the
redemption date, an Officers' Certificate requesting that the Trustee give such
notice and setting forth the information to be stated in such notice as provided
in the preceding paragraph.

SECTION 3.04.     EFFECT OF NOTICE OF REDEMPTION.

          Once notice of redemption is mailed in accordance with Section 3.03
hereof, Notes called for redemption become irrevocably due and payable on the
redemption date at the redemption price. A notice of redemption may not be
conditional.

SECTION 3.05.     DEPOSIT OF REDEMPTION PRICE.

          One Business Day prior to the redemption date, the Company shall
deposit with the Trustee or with the Paying Agent money sufficient to pay the
redemption price of and accrued interest on all Notes to be redeemed on that
date. The Trustee or the Paying Agent shall promptly return to the Company any
money deposited with the Trustee or the Paying Agent by the Company in excess of
the amounts necessary to pay the redemption price of, and accrued interest on,
all Notes to be redeemed.

          If the Company complies with the provisions of the preceding
paragraph,  on and after the redemption date,  interest shall cease to accrue on
the Notes or the portions of Notes called for redemption.  If a Note is redeemed
on or after an interest record date but on or prior to the related

<Page>

interest payment date, then any accrued and unpaid interest shall be paid to the
Person in whose name such Note was registered at the close of business on such
record date. If any Note called for redemption shall not be so paid upon
surrender for redemption because of the failure of the Company to comply with
the preceding paragraph, interest shall be paid on the unpaid principal, from
the redemption date until such principal is paid, and to the extent lawful on
any interest not paid on such unpaid principal, in each case at the rate
provided in the Notes.

SECTION 3.06.     NOTES REDEEMED IN PART.

          Upon surrender of a Note that is redeemed in part, the Company shall
issue and, upon the Company's written request, the Trustee shall authenticate
for the Holder at the expense of the Company a new Note equal in principal
amount to the unredeemed portion of the Note surrendered.

SECTION 3.07.     PROVISIONAL AND OPTIONAL REDEMPTION.

          (a)     The Notes may be redeemed at the election of the Company, as a
whole or in part from time to time, at any time prior to November 3, 2004 (a
"PROVISIONAL REDEMPTION "), upon at least 20 and not more than 60 days' notice
by mail to the Holders of the Notes at a redemption price equal to $1,000 per
$1,000 principal amount of the Notes redeemed plus accrued and unpaid interest,
if any (such amount, together with the Make-Whole Payment described below, the
"PROVISIONAL REDEMPTION PRICE"), to but excluding the date of redemption (the "
PROVISIONAL REDEMPTION DATE") if (1) the Closing Sale Price of the Common Stock
has exceeded 150% of the Conversion Price for at least 20 trading days within a
period of any 30 consecutive trading days ending on the trading day prior to the
date of mailing of the notice of Provisional Redemption (the "NOTICE DATE"), and
(2) a shelf registration statement covering resales of the Notes and the Common
Stock issuable upon conversion thereof is effective and available for use and is
expected to remain effective and available for use for the 30 days following the
Provisional Redemption Date unless registration is no longer required.

          Upon any such Provisional Redemption, the Company, shall make an
additional payment, at its option, in cash or Common Stock or a combination of
cash and Common Stock (the "MAKE-WHOLE PAYMENT") with respect to the Notes
called for redemption to holders on the Notice Date in an amount equal to $165
per $1,000 principal amount of the Notes, less the amount of any interest
actually paid (including, if the Provisional Redemption Date occurs after a
record date but before an interest payment date, any interest paid or to be paid
in connection with such interest payment date) on such Notes on or prior to the
Provisional Redemption Date. Payments made in Common Stock will be valued at 97%
of the average closing sales prices of Common Stock for the five trading days
ending on the day prior to the Redemption Date. The Company shall make the
Make-Whole Payment on all Notes called for Provisional Redemption, including
those Notes converted into Common Stock between the Notice Date and the
Provisional Redemption Date.

          (b)     Except as set forth in clause (a) of this Section 3.07, the
Company shall not have the option to redeem the Notes pursuant to this Section
3.07 prior to November 3, 2004. Thereafter, the Company shall have the option to
redeem the Notes, in whole or in part, at the redemption prices (expressed as
percentages of principal amount) set forth below plus accrued

<Page>

and unpaid interest and Additional Interest thereon, if any, to the applicable
redemption date, if redeemed during the periods set forth below:

<Table>
<Caption>
PERIOD                                                               PERCENTAGE
<S>                                                                   <C>
Beginning November 3, 2004 through October 31, 2005...................103.143%
Beginning November 1, 2005 through October 31, 2006...................102.357%
Beginning November 1, 2006 through October 31, 2007...................101.571%
Beginning November 1, 2007 and thereafter.............................100.786%
</Table>

          (c)     Any redemption pursuant to this Section 3.07 shall be made
pursuant to the provisions of Section 3.01 through 3.06 hereof.

SECTION 3.08.     MANDATORY REDEMPTION.

          The Company shall not be required to make mandatory redemption
payments with respect to the Notes.

                                   ARTICLE 4.
                                   CONVERSION

SECTION 4.01.     CONVERSION PRIVILEGE.

          A Holder of a Note may convert it into fully paid and nonassessable
shares of Common Stock at any time prior to maturity at the Conversion Price
then in effect, except that, with respect to any Note called for redemption or
submitted or presented for purchase pursuant to Section 6.09, such conversion
right shall terminate at the close of business on the Business Day immediately
preceding the redemption date or Repurchase Event Payment Date, as the case may
be (unless the Company shall default in making the redemption payment or
Repurchase Event Payment when it becomes due, in which case the conversion right
shall terminate on the date such default is cured and such Note is redeemed or
purchased, as the case may be). The number of shares of Common Stock issuable
upon conversion of a Note is determined by dividing the principal amount of such
Note by the conversion price in effect on the Conversion Date (the "CONVERSION
PRICE").

          The initial Conversion Price is stated in Section 8 of the Notes and
is subject to adjustment as provided in this Article 4.

          A Holder may convert a portion of a Note equal to any integral
multiple of $1,000. Provisions of this Indenture that apply to conversion of all
of a Note also apply to conversion of a portion of it.

          A Note in respect of which a Holder has delivered a Repurchase Event
Payment Notice pursuant to Section 6.09 exercising the option of such Holder to
require the Company to purchase such Note may be converted only if such
Repurchase Event Payment Notice is withdrawn by a written notice of withdrawal
delivered to a Paying Agent prior to the close of business on the Business Day
immediately preceding the Repurchase Event Payment Date in accordance with
Section 6.09.

<Page>

          A Holder of Notes is not entitled to any rights of a holder of Common
Stock until such Holder has converted its Notes to Common Stock, and only to the
extent such Notes are deemed to have been converted into Common Stock pursuant
to this Article 4.

SECTION 4.02.     CONVERSION PROCEDURE.

          To convert a Note, a Holder must satisfy the requirements in Section 8
of the Notes. The date on which the Holder satisfies all of those requirements
is the conversion date (the "CONVERSION DATE"). As soon as practicable after the
Conversion Date, the Company shall deliver to the Holder through the Conversion
Agent a certificate for the number of whole shares of Common Stock issuable upon
the conversion and a check for any fractional share determined pursuant to
Section 4.03 hereof. The Person in whose name the certificate is registered
shall become the stockholder of record on the Conversion Date and, as of such
date, such Person's rights as a Holder shall cease; PROVIDED, HOWEVER, that no
surrender of a Note on any date when the stock transfer books of the Company
shall be closed shall be effective to constitute the Person entitled to receive
the shares of Common Stock upon such conversion as the stockholder of record of
such shares of Common Stock on such date, but such surrender shall be effective
to constitute the Person entitled to receive such shares of Common Stock as the
stockholder of record thereof for all purposes at the close of business on the
next succeeding day on which such stock transfer books are open; PROVIDED
FURTHER, HOWEVER, that such conversion shall be at the Conversion Price in
effect on the date that such Note shall have been surrendered for conversion, as
if the stock transfer books of the Company had not been closed.

          No payment or other adjustment shall be made for accrued interest or
dividends or distributions on any Common Stock issued upon conversion of the
Notes. If any Notes are converted during any period after any record date for
the payment of an installment of interest but before the next interest payment
date, interest for such notes will be paid on the next interest payment date,
notwithstanding such conversion, to the Holders of such Notes. Any Notes that
are, however, delivered to the Company for conversion after any record date but
before the next interest payment date must, except as described in the next
sentence, be accompanied by a payment equal to the interest payable on such
interest payment date on the principal amount of Notes being converted. The
payment to the Company described in the preceding sentence shall not be required
if, during that period between a record date and the next interest payment date,
a conversion occurs on or after the date that the Company has issued a
redemption notice or Repurchase Event Offer and prior to the date of redemption
stated in such notice or the Repurchase Event Payment Date, as the case may be.
No fractional shares will be issued upon conversion, but a cash adjustment will
be made for any fractional shares.

         If a Holder converts more than one Note at the same time, the number of
whole shares of Common Stock issuable upon the conversion shall be based on the
total principal amount of Notes converted.

         Upon surrender of a Note that is converted in part, the Trustee shall
authenticate for the Holder a new Note equal in principal amount to the
unconverted portion of the Note surrendered.

SECTION 4.03.     FRACTIONAL SHARES.

<Page>

          The Company will not issue fractional shares of Common Stock upon
conversion of a Note. In lieu thereof, the Company will pay an amount in cash
based upon the Closing Sale Price of the Common Stock on the last trading day
prior to the date of conversion.

SECTION 4.04.     TAXES ON CONVERSION.

          The issuance of certificates for shares of Common Stock upon the
conversion of any Note shall be made without charge to the converting Holder for
such certificates or for any tax in respect of the issuance of such
certificates, and such certificates shall be issued in the respective names of,
or in such names as may be directed by, the Holder or Holders of the converted
Note; PROVIDED, HOWEVER, that in the event that certificates for shares of
Common Stock are to be issued in a name other than the name of the Holder of the
Note converted, such Note, when surrendered for conversion, shall be accompanied
by an instrument of transfer, in form satisfactory to the Company, duly executed
by the registered holder thereof or his duly authorized attorney; and PROVIDED
FURTHER, HOWEVER, that the Company shall not be required to pay any tax which
may be payable in respect of any transfer involved in the issuance and delivery
of any such certificates in a name other than that of the Holder of the
converted Note, and the Company shall not be required to issue or deliver such
certificates unless or until the Person or Persons requesting the issuance
thereof shall have paid to the Company the amount of such tax or shall have
established to the satisfaction of the Company that such tax has been paid or is
not applicable.

SECTION 4.05.     COMPANY TO PROVIDE STOCK.

          The Company shall at all times reserve and keep available, free from
preemptive rights, out of its authorized but unissued Common Stock, solely for
the purpose of issuance upon conversion of Notes as herein provided, a
sufficient number of shares of Common Stock to permit the conversion of all
outstanding Notes for shares of Common Stock. All shares of Common Stock which
may be issued upon conversion of the Notes shall be duly authorized, validly
issued, fully paid and nonassessable and free of preemptive rights and free of
any lien or adverse claim when so issued.

          The Company will endeavor promptly to comply with all federal and
state securities laws regulating the offer and delivery of shares of Common
Stock upon conversion of Notes, if any, and will list or cause to have quoted
such shares of Common Stock on each national securities exchange or on the
Nasdaq National Market or other over-the-counter market or such other market on
which the Common Stock is then listed or quoted; PROVIDED, HOWEVER, that if
rules of such automated quotation system or exchange permit the Company to defer
the listing of such Common Stock until the first conversion of the Notes into
Common Stock in accordance with the provisions of this Indenture, the Company
covenants to list such Common Stock issuable upon conversion of the Notes in
accordance with the requirements of such automated quotation system or exchange
at such time.

SECTION 4.06.     ADJUSTMENT OF CONVERSION PRICE.

          The Conversion Price shall be subject to adjustment from time to time
as follows:

<Page>

          (a)     STOCK SPLIT AND COMBINATIONS. In case the Company, at any time
or from time to time after the issuance date of the Notes (a) subdivides or
splits the outstanding shares of its Common Stock, (b) combines or reclassifies
the outstanding shares of its Common Stock into a smaller number of shares or
(c) issues by reclassification of the shares of its Common Stock any shares of
its capital stock, then the Conversion Price in effect immediately prior to that
event or the record date for that event, whichever is earlier, will be adjusted
so that the holder of any Notes thereafter surrendered for conversion will be
entitled to receive the number of shares of the Company's Common Stock or of its
other securities which the Holder would have owned or have been entitled to
receive after the occurrence of any of the events described above, had those
Notes been surrendered for conversion immediately before the occurrence of that
event or the record date for that event, whichever is earlier;

          (b)     STOCK DIVIDENDS IN COMMON STOCK. In case the Company, at any
time or from time to time after the issuance date of the Notes, pays a dividend
or make a distribution in shares of its Common Stock on any class of its capital
stock other than dividends or distributions of shares of Common Stock or other
securities with respect to which adjustments are provided in paragraph (1) above
or with respect to payments of interest or dividend obligations with respect to
a particular series of capital stock in accordance with the terms of such
capital stock, the Conversion Price will be adjusted so that the Holder of each
Note will be entitled to receive, upon conversion of that Note, the number of
shares of the Company's Common Stock determined by multiplying (a) the
Conversion Price by (b) a fraction, the numerator of which will be the number of
shares of Common Stock outstanding and the denominator of which will be the sum
of that number of shares and the total number of shares issued in that dividend
or distribution;

          (c)     ISSUANCE OF RIGHTS OR WARRANTS. In case the Company issues to
all holders of its Common Stock rights or warrants entitling those holders for a
period of not more than 60 days to subscribe for or purchase its Common Stock or
securities convertible into its Common Stock at a price per share or conversion
price per share less than the current market price, the Conversion Price in
effect immediately before the close of business on the record date fixed for
determination of shareholders entitled to receive those rights or warrants will
be reduced by multiplying the Conversion Price by a fraction, the numerator of
which is the sum of the number of shares of the Company's Common Stock
outstanding at the close of business on that record date and the number of
shares of Common Stock that the aggregate offering price of the total number of
shares of the Company's Common Stock so offered for subscription or purchase
would purchase at the current market price and the denominator of which is the
sum of the number of shares of Common Stock outstanding at the close of business
on that record date and the number of additional shares of the Company's Common
Stock so offered for subscription or purchase. For purposes of this paragraph
(c), the issuance of rights or warrants to subscribe for or purchase securities
convertible into shares of the Company's Common Stock will be deemed to be the
issuance of rights or warrants to purchase shares of the Company's Common Stock
into which those securities are convertible at an aggregate offering price equal
to the sum of the aggregate offering price of those securities and the minimum
aggregate amount, if any, payable upon conversion of those securities into
shares of the Company's Common Stock. This adjustment will be made successively
whenever any such event occurs;

<Page>

          (d)     DISTRIBUTION OF INDEBTEDNESS, SECURITIES OR ASSETS. In case
the Company shall distribute to all or substantially all holders of its Common
Stock any shares of capital stock of the Company (other than Common Stock),
evidences of indebtedness or other non-cash assets (including securities of any
person other than the Company but excluding (1) dividends or distributions paid
exclusively in cash or (2) dividends or distributions referred to in subsection
(b) of this Section 4.06), or shall distribute to all or substantially all
holders of its Common Stock rights or warrants to subscribe for or purchase any
of its securities (excluding those rights and warrants referred to in subsection
(c) of this Section 4.06 and also excluding the distribution of rights to all
holders of Common Stock pursuant to the adoption of a stockholders rights plan
or the detachment of such rights under the terms of such stockholder rights
plan), then in each such case the Conversion Price shall be adjusted so that the
same shall equal the price determined by multiplying the current Conversion
Price by a fraction of which the numerator shall be the current market price per
share (as defined in subsection (h) of this Section 4.06) of the Common Stock on
the record date mentioned below less the fair market value on such record date
(as determined by the Board of Directors, whose determination shall be
conclusive evidence of such fair market value and which shall be evidenced by an
Officers' Certificate delivered to the Trustee) of the portion of the capital
stock, evidences of indebtedness or other non-cash assets so distributed or of
such rights or warrants applicable to one share of Common Stock (determined on
the basis of the number of shares of Common Stock outstanding on the record
date), and of which the denominator shall be the current market price per share
(as defined in subsection (h) of this Section 4.06) of the Common Stock on such
record date. Such adjustment shall be made successively whenever any such
distribution is made and shall become effective immediately after the record
date for the determination of shareholders entitled to receive such
distribution.

          (e)     In case the Company shall, by dividend or otherwise, at any
time distribute (a "TRIGGERING DISTRIBUTION") to all or substantially all
holders of its Common Stock cash in an aggregate amount that, together with the
aggregate amount of (A) any cash and the fair market value (as determined by the
Board of Directors, whose determination shall be conclusive evidence thereof and
which shall be evidenced by an Officers' Certificate delivered to the Trustee)
of any other consideration payable in respect of any tender offer by the Company
or a Subsidiary of the Company for Common Stock consummated within the 12 months
preceding the date of payment of the Triggering Distribution and in respect of
which no Conversion Price adjustment pursuant to this Section 4.06 has been made
and (B) all other cash distributions to all or substantially all holders of its
Common Stock made within the 12 months preceding the date of payment of the
Triggering Distribution and in respect of which no Conversion Price adjustment
pursuant to this Section 4.06 has been made, exceeds an amount equal to 10.0% of
the product of the current market price per share of Common Stock (as determined
in accordance with subsection (h) of this Section 4.06) on the Business Day (the
"DETERMINATION DATE") immediately preceding the day on which such Triggering
Distribution is declared by the Company multiplied by the number of shares of
Common Stock outstanding on the Determination Date (excluding shares held in the
treasury of the Company), the Conversion Price shall be reduced so that the same
shall equal the price determined by multiplying such Conversion Price in effect
immediately prior to the Determination Date by a fraction of which the numerator
shall be the current market price per share of the Common Stock (as determined
in accordance with subsection (g) of this Section 4.06) on the Determination
Date less the sum of the aggregate amount of cash and the aggregate fair market
value (determined as aforesaid in this Section 4.06(e)) of any such other
consideration so distributed, paid or payable within such 12

<Page>

months (including, without limitation, the Triggering Distribution) applicable
to one share of Common Stock (determined on the basis of the number of shares of
Common Stock outstanding on the Determination Date) and the denominator shall be
such current market price per share of the Common Stock (as determined in
accordance with subsection (h) of this Section 4.06) on the Determination Date,
such reduction to become effective immediately prior to the opening of business
on the day following the date on which the Triggering Distribution is paid.

          (f)     In case any tender offer made by the Company or any of its
Subsidiaries for Common Stock shall expire and such tender offer (as amended
upon the expiration thereof) shall involve the payment of aggregate
consideration in an amount (determined as the sum of the aggregate amount of
cash consideration and the aggregate fair market value (as determined by the
Board of Directors, whose determination shall be conclusive evidence thereof and
which shall be evidenced by an Officers' Certificate delivered to the Trustee
thereof) of any other consideration) that, together with the aggregate amount of
(A) any cash and the fair market value (as determined by the Board of Directors,
whose determination shall be conclusive evidence thereof and which shall be
evidenced by an Officers' Certificate delivered to the Trustee) of any other
consideration payable in respect of any other tender offers by the Company or
any Subsidiary of the Company for Common Stock consummated within the 12 months
preceding the date of the Expiration Date (as defined below) and in respect of
which no Conversion Price adjustment pursuant to this Section 4.06 has been made
and (B) all cash distributions to all or substantially all holders of its Common
Stock made within the 12 months preceding the Expiration Date and in respect of
which no Conversion Price adjustment pursuant to this Section 4.06 has been
made, exceeds an amount equal to 10.0% of the product of the current market
price per share of Common Stock (as determined in accordance with subsection (h)
of this Section 4.06) as of the last date (the "EXPIRATION DATE") tenders could
have been made pursuant to such tender offer (as it may be amended) (the last
time at which such tenders could have been made on the Expiration Date is
hereinafter sometimes called the "EXPIRATION TIME") multiplied by the number of
shares of Common Stock outstanding (including tendered shares but excluding any
shares held in the treasury of the Company) at the Expiration Time, then,
immediately prior to the opening of business on the day after the Expiration
Date, the Conversion Price shall be reduced so that the same shall equal the
price determined by multiplying the Conversion Price in effect immediately prior
to close of business on the Expiration Date by a fraction of which the numerator
shall be the product of the number of shares of Common Stock outstanding
(including tendered shares but excluding any shares held in the treasury of the
Company) at the Expiration Time multiplied by the current market price per share
of the Common Stock (as determined in accordance with subsection (h) of this
Section 4.06) on the trading day next succeeding the Expiration Date and the
denominator shall be the sum of (x) the aggregate consideration (determined as
aforesaid) payable to stockholders based on the acceptance (up to any maximum
specified in the terms of the tender offer) of all shares validly tendered and
not withdrawn as of the Expiration Time (the shares deemed so accepted, up to
any such maximum, being referred to as the "PURCHASED SHARES") and (y) the
product of the number of shares of Common Stock outstanding (less any Purchased
Shares and excluding any shares held in the treasury of the Company) at the
Expiration Time and the current market price per share of Common Stock (as
determined in accordance with subsection (h) of this Section 4.06) on the
trading day next succeeding the Expiration Date, such reduction to become
effective immediately prior to the opening of business on the day following the
Expiration Date. In the event that the Company is obligated to purchase shares
pursuant to any such tender offer, but the

<Page>

Company is permanently prevented by applicable law from effecting any or all
such purchases or any or all such purchases are rescinded, the Conversion Price
shall again be adjusted to be the Conversion Price which would have been in
effect based upon the number of shares actually purchased. If the application of
this Section 4.06(f) to any tender offer would result in an increase in the
Conversion Price, no adjustment shall be made for such tender offer under this
Section 4.06(f).

          (g) In case of a tender or exchange offer made by a person other than
the Company or any of its Subsidiaries for an amount which increases the
offeror's ownership of Common Stock to more than 25% of the Common Stock
outstanding and shall involve the payment by such person of consideration per
share of Common Stock having a fair market value (as determined by the Board of
Directors, whose determination shall be conclusive, and described in a
resolution of the Board of Directors at the last time (the "TENDER EXPIRATION
TIME") tenders or exchanges may be made pursuant to such tender or exchange
offer (as it shall have been amended)) that exceeds the current market price of
the Common Stock on the trading day next succeeding the Tender Expiration Time,
and in which, as of the Tender Expiration Time the Board of Directors is not
recommending rejection of the offer, the Conversion Price shall be reduced so
that the same shall equal the price determined by multiplying the Conversion
Price in effect immediately prior to the Tender Expiration Time by a fraction of
which the numerator shall be the number of shares of Common Stock outstanding
(including any tendered or exchanged shares) on the Tender Expiration Time
multiplied by the current market price of the Common Stock on the trading day
next succeeding the Tender Expiration Time and the denominator shall be the sum
of (x) the fair market value (determined as aforesaid) of the aggregate
consideration payable to shareholders based on the acceptance (up to any maximum
specified in the terms of the tender or exchange offer) of all shares validly
tendered or exchanged and not withdrawn as of the Tender Expiration Time (the
shares deemed so accepted, up to any such maximum, being referred to as the
"TENDER PURCHASED SHARES") and (y) the product of the number of shares of Common
Stock outstanding (less any Tender Purchased Shares) on the Tender Expiration
Time and the current market price of the Common Stock on the trading day next
succeeding the Tender Expiration Time, such reduction to become effective
immediately prior to the opening of business on the day following the Tender
Expiration Time. In the event that such person is obligated to purchase shares
pursuant to any such tender or exchange offer, but such person is permanently
prevented by applicable law from effecting any such purchases or all such
purchases are rescinded, the Conversion Price shall again be adjusted to be the
Conversion Price which would then be in effect if such tender or exchange offer
had not been made. Notwithstanding the foregoing, the adjustment described in
this Section 4.06(g) shall not be made if, as of the Tender Expiration Time, the
offering documents with respect to such offer disclose a plan or intention to
cause the Company to engage in any transaction described in Section 4.12 or if
such tender or exchange offer increases the offeror's ownership of Common Stock
to 100%.

          (h)     For purposes of Sections 4.06(f) and (g), the term "TENDER
OFFER" shall mean and include both tender offers and exchange offers, all
references to "purchases" of shares in tender offers (and all similar
references) shall mean and include both the purchase of shares in tender offers
and the acquisition of shares pursuant to exchange offers, and all references to
"tendered shares" (and all similar references) shall mean and include shares
tendered in both tender offers and exchange offers. For the purpose of any
computation under subsections (b), (c), (d), (e), (f)

<Page>

and (g) of this Section 4.06, the current market price per share of Common Stock
on any date shall be deemed to be the average of the daily Closing Sale Prices
for the 30 consecutive trading days commencing 45 trading days before (i) the
Determination Date or the Expiration Date, as the case may be, with respect to
distributions or tender offers under subsections (f) and (g) of this Section
4.06 or (ii) the record date with respect to distributions, issuances or other
events requiring such computation under subsection (a), (c), or (d) of this
Section 4.06. If no such prices are available, the current market price per
share shall be the fair value of share of Common Stock as determined by the
Board of Directors (which shall be evidenced by an Officers' Certificate
delivered to the Trustee).

          (i)     If any distribution in respect of which an adjustment to the
Conversion Price is required to be made as of the record date or Determination
Date or Expiration Date therefor is not thereafter made or paid by the Company
for any reason, the Conversion Price shall be readjusted to the Conversion Price
which would then be in effect if such record date had not been fixed or such
effective date or Determination Date or Expiration Date had not occurred.

SECTION 4.07.     NO ADJUSTMENT.

          No adjustment in the Conversion Price shall be required until
cumulative adjustments amount to 1% or more of the Conversion Price as last
adjusted; PROVIDED, HOWEVER, that any adjustments which by reason of this
Section 4.07 are not required to be made shall be carried forward and taken into
account in any subsequent adjustment. All calculations under this Article 4
shall be made to the nearest cent or to the nearest one-hundredth of a share, as
the case may be. No adjustment need be made for rights to purchase Common Stock
pursuant to a Company plan for reinvestment of dividends or interest. No
adjustment need be made for a change in the par value or no par value of the
Common Stock.

SECTION 4.08.     OTHER ADJUSTMENTS.

          (a)     In the event that, as a result of an adjustment made pursuant
to Section 4.06 hereof, the Holder of any Note thereafter surrendered for
conversion shall become entitled to receive any shares of Capital Stock of the
Company other than shares of its Common Stock, thereafter the Conversion Price
of such other shares so receivable upon conversion of any Note shall be subject
to adjustment from time to time in a manner and on terms as nearly equivalent as
practicable to the provisions with respect to Common Stock contained in this
Article 4.

          (b)     In the event that shares of Common Stock are not delivered
after the expiration of any of the rights or warrants referred to in Section
4.06(b) and Section 4.06(c) hereof, the Conversion Price shall be readjusted to
the Conversion Price which would otherwise be in effect had the adjustment made
upon the issuance of such rights or warrants been made on the basis of delivery
of only the number of shares of Common Stock actually delivered.

SECTION 4.09.     ADJUSTMENTS FOR TAX PURPOSES.

          The Company may make such reductions in the Conversion Price, in
addition to those required by Section 4.06 hereof, as it determines in its
discretion to be advisable in order that any stock dividend, subdivision of
shares, distribution or rights to purchase stock or securities or

<Page>

distribution of securities convertible into or exchangeable for stock made by
the Company to its stockholders will not be taxable to the recipients thereof.

SECTION 4.10.     NOTICE OF ADJUSTMENT.

          Whenever the Conversion Price is adjusted, the Company shall promptly
mail to Holders at the addresses appearing on the Registrar's books a notice of
the adjustment and file with the Trustee an Officers' Certificate briefly
stating the facts requiring the adjustment and the manner of computing it. The
certificate shall be conclusive evidence of the correctness of such adjustment.
Unless and until a Responsible Officer of the Trustee shall receive written
notice of an adjustment of the Conversion Price, the Trustee may assume without
inquiry that the Conversion Price has not been adjusted and that the last
Conversion Price of which it has knowledge remains in effect.

SECTION 4.11.     NOTICE OF CERTAIN TRANSACTIONS.

          In the event that:

          (1) the Company takes any action which would require an adjustment in
the Conversion Price;

          (2) the Company takes any action that would require a supplemental
indenture pursuant to Section 4.12; or

          (3) there is a dissolution or liquidation of the Company;

          the Company shall mail to Holders at the addresses appearing on the
Registrar's books and the Trustee a notice stating the proposed record or
effective date, as the case may be, to permit a Holder of a Note to convert such
Note into shares of Common Stock prior to the record date for or the effective
date of the transaction in order to receive the rights, warrants, securities or
assets which a holder of shares of Common Stock on that date may receive. The
Company shall mail the notice at least 15 days before such date; however,
failure to mail such notice or any defect therein shall not affect the validity
of any transaction referred to in clause (1), (2) or (3) of this Section 4.11.

SECTION 4.12.     EFFECT OF RECLASSIFICATIONS, CONSOLIDATIONS, MERGERS OR SALES
ON CONVERSION PRIVILEGE.

          If any of the following shall occur, namely: (i) any reclassification
or change of outstanding shares of Common Stock issuable upon conversion of
Notes (other than a change in par value, or from par value to no par value, or
from no par value to par value, or as a result of a subdivision or combination
or as a result of a reincorporation of the Company in another jurisdiction),
(ii) any consolidation or merger to which the Company is a party other than a
merger in which the Company is the continuing corporation and which does not
result in any reclassification of, or change (other than a change in name, or
par value, or from par value to no par value, or from no par value to par value
or as a result of a subdivision or combination) in, outstanding shares of Common
Stock or (iii) any sale or conveyance of all or substantially all of

<Page>

the property or business of the Company as an entirety, then the Company, or
such successor or purchasing corporation, as the case may be, shall, as a
condition precedent to such reclassification, change, consolidation, merger,
sale or conveyance, execute and deliver to the Trustee a supplemental indenture
in form reasonably satisfactory to the Trustee providing that the Holder of each
Note then outstanding shall have the right to convert such Note into the kind
and amount of shares of stock and other securities and property (including cash)
receivable upon such reclassification, change, consolidation, merger, sale or
conveyance by a Holder of the number of shares of Common Stock deliverable upon
conversion of such Note immediately prior to such reclassification, change,
consolidation, merger, sale or conveyance. In the event that the shares of
Common Stock are exchanged or substituted for other securities in connection
with any such reclassification, change, consolidation, merger, sale or
conveyance, such supplemental indenture shall provide for adjustments of the
Conversion Price which shall be as nearly equivalent as may be practicable to
the adjustments of the Conversion Price provided for in this Article 4. If, in
the case of any such consolidation, merger, sale or conveyance, the stock or
other securities and property (including cash) receivable thereupon by a Holder
of Common Stock includes shares of stock or other securities and property of a
corporation other than the successor or purchasing corporation, as the case may
be, in such consolidation, merger, sale or conveyance, then such supplemental
indenture shall also be executed by such other corporation and shall contain
such additional provisions to protect the interests of the Holders of the Notes
as the Board of Directors of the Company shall reasonably consider necessary by
reason of the foregoing. The provision of this Section 4.12 shall similarly
apply to successive consolidations, mergers, sales or conveyances.

          In the event the Company shall execute a supplemental indenture
pursuant to this Section 4.12, the Company shall promptly file with the Trustee
an Officers' Certificate briefly stating the reasons therefor, the kind or
amount of shares of stock or securities or property (including cash) receivable
by Holders of the Notes upon the conversion of their Notes after any such
reclassification, change, consolidation, merger, sale or conveyance and any
adjustment to be made with respect thereto.

SECTION 4.13.     TRUSTEE'S DISCLAIMER.

          The Trustee has no duty to determine when an adjustment under this
Article 4 should be made, how it should be made or what such adjustment should
be, but may accept as conclusive evidence of the correctness of any such
adjustment, and shall be protected in relying upon, the Officers' Certificate
with respect thereto which the Company is obligated to file with the Trustee
pursuant to Section 4.10 hereof. The Trustee makes no representation as to the
validity or value of any securities or assets issued upon conversion of Notes,
and the Trustee shall not be responsible for the Company's failure to comply
with any provisions of this Article 4.

          The Trustee shall not be under any responsibility to determine the
correctness of any provisions contained in any supplemental indenture executed
pursuant to Section 4.12, but may accept as conclusive evidence of the
correctness thereof, and shall be protected in relying upon, the Officers'
Certificate with respect thereto which the Company is obligated to file with the
Trustee pursuant to Section 4.12 hereof.

SECTION 4.14.     VOLUNTARY REDUCTION.

<Page>

          The Company from time to time may reduce the Conversion Price by any
amount for any period of time if the period is at least 20 days and if the
reduction is irrevocable during the period if the Board of Directors determines
that such reduction would be in the best interest of the Company and the Company
provides 15 days prior notice of any reduction in the Conversion Price;
PROVIDED, HOWEVER, that in no event may the Company reduce the Conversion Price
to be less than the par value of a share of Common Stock.

                                   ARTICLE 5.
                                  SUBORDINATION

SECTION 5.01.     AGREEMENT TO SUBORDINATE.

          The Company agrees, and each Holder by accepting a Note agrees, that
the Indebtedness evidenced by the Notes (including the principal of, premium, if
any, and interest (including Additional Interest, if any) on all the Notes and
the redemption price and Make-Whole Payment, if any, with respect to any Notes
being called for redemption and the Repurchase Event Payment with respect to all
Notes subject to purchase pursuant to Section 6.09 hereof) is subordinated in
right of payment, to the extent and in the manner provided in this Article 5, to
the prior payment in full of all Senior Indebtedness (whether outstanding on the
date hereof or hereafter created, incurred, assumed or guaranteed), and that the
subordination is for the benefit of the holders of Senior Indebtedness. No
provision of this Section 5 shall prevent the occurrence of any Default or Event
of Default.

SECTION 5.02.     LIQUIDATION; DISSOLUTION; BANKRUPTCY.

          Upon any distribution to creditors of the Company in a liquidation or
dissolution of the Company or in a bankruptcy, reorganization, insolvency,
receivership or similar proceeding relating to the Company or its property, in
an assignment for the benefit of creditors or any marshaling of the Company's
assets and liabilities:

                  (i)     holders of Senior Indebtedness shall be entitled to
          receive payment in full of all Obligations due in respect of such
          Senior Indebtedness (including interest after the commencement of any
          such proceeding at the rate specified in the applicable Senior
          Indebtedness) before Holders of the Notes shall be entitled to receive
          any payment with respect to the Notes (except that Holders may receive
          Permitted Junior Securities); and

                  (ii)    until all Obligations with respect to Senior
          Indebtedness (as provided in clause (i) above) are paid in full, any
          distribution to which Holders would be entitled but for this Article 5
          shall be made to holders of Senior Indebtedness (except that Holders
          of Notes may receive Permitted Junior Securities), as their interests
          may appear.

SECTION 5.03.     DEFAULT ON DESIGNATED SENIOR INDEBTEDNESS.

          (a)     The Company may not make any payment or distribution to the
Trustee or any Holder in respect of Obligations with respect to the Notes and
may not acquire from the Trustee or any Holder any Notes for cash or property
(other than Permitted Junior Securities) until all principal and other
Obligations with respect to the Senior Indebtedness have been paid in full if:

<Page>

                  (i)     a default in the payment of any principal or other
          Obligations with respect to Designated Senior Indebtedness occurs and
          is continuing beyond any applicable grace period in the agreement,
          indenture or other document governing such Designated Senior
          Indebtedness; or

                  (ii)    a default, other than a payment default, on Designated
          Senior Indebtedness occurs and is continuing that then permits holders
          of the Designated Senior Indebtedness to accelerate its maturity and
          the Trustee receives a notice of the default (a "PAYMENT BLOCKAGE
          NOTICE") from a Person who may give it pursuant to Section 5.12
          hereof. If the Trustee receives any such Payment Blockage Notice, no
          subsequent Payment Blockage Notice shall be effective for purposes of
          this Section unless and until (A) at least 360 days shall have elapsed
          since the issuance of the immediately prior Payment Blockage Notice
          and (B) all scheduled payments of principal, premium, if any, and
          interest on the Notes that have come due have been paid in full in
          cash. No nonpayment default that existed or was continuing on the date
          of delivery of any Payment Blockage Notice to the Trustee shall be, or
          be made, the basis for a subsequent Payment Blockage Notice unless
          such default shall have been waived for a period of not less than 180
          days.

          (b)     The Company may and shall resume payments on and distributions
in respect of the Notes and may acquire them upon the earlier of:

                  (i)     the date upon which the Trustee receives notice from
          the Company that the default is cured or waived or ceases to exist, or

                  (ii)    in the case of a default referred to in clause (ii) of
          Section 5.03(a) hereof, 179 days pass after the Payment Blockage
          Notice is received if the maturity of such Designated Senior
          Indebtedness has not been accelerated,

         if this Article 5 otherwise permits the payment, distribution or
acquisition at the time of such payment or acquisition.

SECTION 5.04.     ACCELERATION OF NOTES.

          If payment of the Notes is accelerated because of an Event of Default,
the Company shall promptly notify holders of Senior Indebtedness of the
acceleration.

SECTION 5.05.     WHEN DISTRIBUTION MUST BE PAID OVER.

          In the event that the Trustee or any Holder receives any payment of
any Obligations or distribution of assets of the Company of any kind or
character (other than Permitted Junior Securities pursuant to Section 5 hereof),
whether in cash, property or securities (including, without limitation, by way
of setoff or otherwise) with respect to the Notes at a time when the Trustee or
such Holder, as applicable, has actual knowledge that such payment is prohibited
by Section 5.03 hereof, such payment shall be held by the Trustee or such
Holder, in trust for the benefit of, and shall be paid forthwith over and
delivered, upon written request, to, the holders of Senior Indebtedness as their
interests may appear or their Representative under the indenture or

<Page>

other agreement (if any) pursuant to which Senior Indebtedness may have been
issued, as their respective interests may appear, for application to the payment
of all Obligations with respect to Senior Indebtedness remaining unpaid to the
extent necessary to pay such Obligations in full in accordance with their terms,
after giving effect to any concurrent payment or distribution to or for the
holders of Senior Indebtedness.

          With respect to the holders of Senior Indebtedness, the Trustee
undertakes to perform only such obligations on the part of the Trustee as are
specifically set forth in this Article 5, and no implied covenants or
obligations with respect to the holders of Senior Indebtedness shall be read
into this Indenture against the Trustee. The Trustee shall not be deemed to owe
any fiduciary duty to the holders of Senior Indebtedness, and shall not be
liable to any such holders if the Trustee shall pay over or distribute to or on
behalf of Holders or the Company or any other Person money or assets to which
any holders of Senior Indebtedness shall be entitled by virtue of this Article
5, except if such payment is made as a result of the willful misconduct or gross
negligence of the Trustee.

SECTION 5.06.     NOTICE BY COMPANY.

          The Company shall promptly notify the Trustee and the Paying Agent of
any facts known to the Company that would cause a payment of any Obligations
with respect to the Notes to violate this Article 5, but failure to give such
notice shall not affect the subordination of the Notes to the Senior
Indebtedness as provided in this Article 5.

SECTION 5.07.     SUBROGATION.

          After all Senior Indebtedness is paid in full in cash or other payment
satisfactory to the holders of the Senior Indebtedness and until the Notes are
paid in full, Holders of Notes shall be subrogated (equally and ratably with all
other Indebtedness pari passu with the Notes and entitled to similar rights of
subrogation) to the rights of holders of Senior Indebtedness to receive payments
or distributions applicable to Senior Indebtedness to the extent that payments
or distributions otherwise payable to the Holders of Notes have been applied to
the payment of Senior Indebtedness. A distribution made under this Article 5 to
holders of Senior Indebtedness that otherwise would have been made to Holders of
Notes (whether by the Company, any Holder, the Trustee or otherwise) is not, as
between the Company and Holders, a payment by the Company on the Notes.

SECTION 5.08.     RELATIVE RIGHTS.

          This Article 5 defines the relative rights of Holders of Notes and
holders of Senior Indebtedness. Nothing in this Indenture shall:

                  (i)     impair, as between the Company and Holders of Notes,
          the obligation of the Company, which is absolute and unconditional, to
          pay principal of, premium, if any, and interest (including Additional
          Interest) on the Notes in accordance with their terms;

                  (ii)    affect the  relative  rights of Holders of Notes and
          creditors  of the Company  other than their  rights in relation to
          holders of Senior Indebtedness; or

<Page>

                  (iii)   prevent the Trustee or any Holder of Notes from
         exercising its available remedies upon a Default or Event of Default,
         subject to the rights of holders and owners of Senior Indebtedness to
         receive distributions and payments otherwise payable to Holders of
         Notes.

          If the Company fails because of this Article 5 to pay principal of,
premium, if any, or interest (including Additional Interest) on a Note on the
due date, the failure is still a Default or Event of Default.

SECTION 5.09.     SUBORDINATION MAY NOT BE IMPAIRED BY COMPANY.

          No right of any holder of Senior Indebtedness to enforce the
subordination of the Indebtedness evidenced by the Notes shall be impaired by
any act or failure to act by the Company or any Holder or by the failure of the
Company or any Holder to comply with this Indenture.

SECTION 5.10.     DISTRIBUTION OR NOTICE TO REPRESENTATIVE.

          Whenever a distribution is to be made or a notice given to holders of
Senior Indebtedness, the distribution may be made and the notice given to their
Representative. Upon any payment or distribution of assets of the Company
referred to in this Article 5, the Trustee and the Holders of Notes shall be
entitled to rely upon any order or decree made by any court of competent
jurisdiction or upon any certificate of such Representative or of the
liquidating trustee or agent or other Person making any distribution to the
Trustee or to the Holders of Notes for the purpose of ascertaining the Persons
entitled to participate in such distribution, the holders of the Senior
Indebtedness and other Indebtedness of the Company, the amount thereof or
payable thereon, the amount or amounts paid or distributed thereon and all other
facts pertinent thereto or to this Article 5.

SECTION 5.11.     RIGHTS OF TRUSTEE AND PAYING AGENT.

          Notwithstanding the provisions of this Article 5 or any other
provision of this Indenture, the Trustee shall not be charged with knowledge of
the existence of any facts that would prohibit the making of any payment or
distribution by the Trustee, and the Trustee and the Paying Agent may continue
to make payments on the Notes, unless the Trustee shall have received at its
Corporate Trust Office at least two Business Days prior to the date of such
payment written notice of facts that would cause the payment of any Obligations
with respect to the Notes to violate this Article 5. Only the Company, a
Representative or a holder of Designated Senior Indebtedness may give the
notice. Nothing in this Article 5 shall impair the claims of, or payments to,
the Trustee under or pursuant to Section 9.07 hereof.

          The Trustee in its individual or any other capacity may hold Senior
Indebtedness with the same rights it would have if it were not Trustee. Any
Agent may do the same with like rights.

SECTION 5.12.     AUTHORIZATION TO EFFECT SUBORDINATION.

<Page>

          Each Holder of Notes, by the Holder's acceptance thereof, authorizes
and directs the Trustee on such Holder's behalf to take such action as may be
necessary or appropriate to effectuate the subordination as provided in this
Article 5, and appoints the Trustee to act as such Holder's attorney-in-fact for
any and all such purposes. If the Trustee does not file a proper proof of claim
or proof of debt in the form required in any proceeding referred to in Section
8.09 hereof at least 30 days before the expiration of the time to file such
claim, the holders of any Designated Senior Indebtedness are hereby authorized
to file an appropriate claim for and on behalf of the Holders of the Notes.

SECTION 5.13.     AMENDMENTS.

          The provisions of this Article 5 shall not be amended or modified in
any manner without the written consent of all of the holders of Designated
Senior Indebtedness; and the provisions of this Article 5 shall not be amended
or modified in any manner detrimental to the holders of Senior Indebtedness
without the written consent of the holders of all Senior Indebtedness.

SECTION 5.14.     AGREEMENT TO SUBORDINATE UNAFFECTED.

          The provisions of this Article 5 shall remain in full force and effect
irrespective of (a) any amendment, modification, or supplement of, or any waiver
or consent to, any of the terms of the Senior Indebtedness or the agreement or
instrument governing the Senior Indebtedness, (b) the release or non-perfection
of any collateral securing the Senior Indebtedness or (c) the manner of sale or
other disposition of the collateral securing the Senior Indebtedness or the
application of the proceeds upon such sale.

SECTION 5.15.     CERTAIN CONVERSIONS DEEMED PAYMENT.

          For the purposes of this Article 5 only, (1) the issuance and delivery
of Permitted Junior Securities upon conversion of Notes in accordance with
Article 4 shall not be deemed to constitute a payment or distribution on account
of the principal of, or premium, if any, or interest (including Additional
Interest) on the Notes or on account of the purchase or other acquisition of
Notes, and (2) the payment, issuance or delivery of cash (except in satisfaction
of fractional shares pursuant to Section 4.03), property or securities (other
than Permitted Junior Securities) upon conversion of a Note shall be deemed to
constitute payment on account of the principal of such Note. Nothing contained
in this Article 5 or elsewhere in this Indenture or in the Notes is intended to
or shall impair, as among the Company, its creditors other than holders of
Senior Indebtedness and the Holders, the right, which is absolute and
unconditional, of the Holder of any Note to convert such Note in accordance with
Article 4.

                                   ARTICLE 6.
                                    COVENANTS

SECTION 6.01.     PAYMENT OF NOTES.

         The Company shall pay or cause to be paid the principal of, premium, if
any,

<Page>

and interest on the Notes on the dates and in the manner provided in the
Notes. Principal, premium, if any, and interest shall be considered paid on the
date due if the Paying Agent, if other than the Company or a Subsidiary thereof,
holds as of 10:00, New York City time, on the due date money deposited by the
Company in immediately available funds and designated for and sufficient to pay
all principal, premium, if any, and interest then due. The Company shall pay all
Additional Interest, if any, in the same manner on the dates and in the amounts
set forth in the Registration Rights Agreement.

          The Company shall pay interest (including post-petition interest in
any proceeding under any Bankruptcy Law) on overdue principal at the rate borne
by the Notes to the extent lawful; it shall pay interest (including
post-petition interest in any proceeding under any Bankruptcy Law) on overdue
installments of interest and Additional Interest (without regard to any
applicable grace period) at the same rate to the extent lawful.

SECTION 6.02.     MAINTENANCE OF OFFICE OR AGENCY.

          The Company shall maintain in the Borough of Manhattan, the City of
New York, a Paying Agent, Conversion Agent, Registrar and an office or agency
(which may be an office of the Trustee or an affiliate of the Trustee, Registrar
or co-registrar) where Notes may be surrendered for registration of transfer or
for exchange and where notices and demands to or upon the Company in respect of
the Notes and this Indenture may be served. The Company shall give prompt
written notice to the Trustee of the location, and any change in the location,
of such office or agency. If at any time the Company shall fail to maintain any
such required office or agency or shall fail to furnish the Trustee with the
address thereof, such presentations, surrenders, notices and demands may be made
or served at the Corporate Trust Office of the Trustee.

          The Company may also from time to time designate one or more other
offices or agencies where the Notes may be presented or surrendered for any or
all such purposes and may from time to time rescind such designations; PROVIDED,
HOWEVER, that no such designation or rescission shall in any manner relieve the
Company of its obligation to maintain an office or agency in the Borough of
Manhattan, the City of New York for such purposes. The Company shall give prompt
written notice to the Trustee of any such designation or rescission and of any
change in the location of any such other office or agency.

          The Company hereby designates the Corporate Trust Office of the
Trustee as one such office or agency of the Company in accordance with Section
2.03.

SECTION 6.03.     REPORTS.

          Whether or not required by the rules and regulations of the SEC, so
long as any Notes are outstanding, the Company shall furnish to the Holders of
Notes (i) all quarterly and annual financial information that would be required
to be contained in a filing with the SEC on Forms 10-Q and 10-K if the Company
were required to file such forms, including a "Management's Discussion and
Analysis of Financial Condition and Results of Operations" and, with respect to
the annual information only, a report thereon by the Company's certified
independent accountants and (ii) all current reports that would be required to
be filed with the SEC on Form 8-K if the Company were required to file such
reports, in each case, within the time periods

<Page>

specified in the SEC's rules and regulations; provided, that if the Company
files the reports required by this Section 6.03 with the SEC and such reports
are publicly available, it shall be deemed to have satisfied its obligation to
furnish such reports to the Holders pursuant to this Section 6.03. The Company
shall at all times comply with TIA Section 314(a).

          Delivery of such reports, information and documents to the Trustee is
for informational purposes only and the Trustee's receipt of such shall not
constitute constructive notice of any information contained therein or
determinable from information contained therein, including the Company's
compliance with any of its covenants hereunder (as to which the Trustee is
entitled to rely exclusively on Officers' Certificates).

SECTION 6.04.     RULE 144A INFORMATION REQUIREMENT.

          Within the period prior to the expiration of the holding period
applicable to sales thereof under Rule 144(k) under the Securities Act (or any
successor provision), the Company covenants and agrees that it shall, during any
period in which it is not subject to Section 13 or 15(d) under the Exchange Act,
make available to any Holder or beneficial holder of Notes or any Common Stock
issued upon conversion thereof which continue to be Restricted Notes in
connection with any sale thereof and any prospective purchaser of Notes or such
Common Stock designated by such Holder or beneficial holder, the information
required pursuant to Rule 144A(d)(4) under the Securities Act upon the request
of any Holder or beneficial holder of the Notes or such Common Stock and it will
take such further action as any Holder or beneficial holder of such Notes or
such Common Stock may reasonably request, all to the extent required from time
to time to enable such Holder or beneficial holder to sell its Notes or Common
Stock without registration under the Securities Act within the limitation of the
exemption provided by Rule 144A, as such Rule may be amended from time to time.
Upon the request of any Holder or any beneficial holder of the Notes or such
Common Stock, the Company will deliver to such Holder a written statement as to
whether it has complied with such requirements.

SECTION 6.05.     COMPLIANCE CERTIFICATE.

          (a)     The Company shall deliver to the Trustee, within 90 days after
the end of each fiscal year, an Officers'  Certificate  stating that a review of
the activities of the Company and its  Subsidiaries  during the preceding fiscal
year has been made under the supervision of the signing  Officers with a view to
determining whether the Company has kept, observed,  performed and fulfilled its
obligations under this Indenture,  and further stating,  as to each such Officer
signing  such  certificate,  that to the best of his or her  knowledge,  in such
Officer's capacity as an officer of the Company, the Company has kept, observed,
performed and fulfilled each and every covenant  contained in this Indenture and
is not in default  (without regard to grace periods or notice  requirements)  in
the performance or observance of any of the terms,  provisions and conditions of
this  Indenture  (or,  if a Default  or Event of Default  shall  have  occurred,
describing  all such  Defaults  or Events of Default of which he or she may have
knowledge and what action the Company is taking or proposes to take with respect
thereto)  and  that to the  best  of his or her  knowledge,  in  such  Officer's
capacity  as an officer of the  Company,  no event has  occurred  and remains in
existence  by  reason  of which  payments  on  account  of the  principal  of or
interest, if

<Page>

any, on the Notes is prohibited or if such event has occurred,  a description of
the event and what action the Company is taking or proposes to take with respect
thereto.

          (b)     The Company shall, so long as any of the Notes are
outstanding, deliver to the Trustee, forthwith upon any Officer becoming aware
of any Default or Event of Default, an Officers' Certificate specifying such
Default or Event of Default and what action the Company is taking or proposes to
take with respect thereto.

SECTION 6.06.     TAXES.

          The Company shall pay, and shall cause each of its Subsidiaries to
pay, prior to delinquency, all material taxes, assessments, and governmental
levies except such as are contested in good faith and by appropriate proceedings
or where the failure to effect such payment is not adverse in any material
respect to the Holders of the Notes.

SECTION 6.07.     STAY, EXTENSION AND USURY LAWS.

          The Company covenants (to the extent that it may lawfully do so) that
it shall not at any time insist upon, plead, or in any manner whatsoever claim
or take the benefit or advantage of, any stay, extension or usury law wherever
enacted, now or at any time hereafter in force, that may affect the covenants or
the performance of this Indenture; and the Company (to the extent that it may
lawfully do so) hereby expressly waives all benefit or advantage of any such
law, and covenants that it shall not, by resort to any such law, hinder, delay
or impede the execution of any power herein granted to the Trustee, but shall
suffer and permit the execution of every such power as though no such law has
been enacted.

SECTION 6.08.     CORPORATE EXISTENCE.

          Subject to Article 7 hereof, the Company shall do or cause to be done
all things necessary to preserve and keep in full force and effect (i) its
corporate existence, and the corporate, partnership or other existence of each
of its Subsidiaries, in accordance with the respective organizational documents
(as the same may be amended from time to time) of the Company or any such
Subsidiary and (ii) the rights (charter and statutory), licenses and franchises
of the Company and its Subsidiaries; PROVIDED, HOWEVER, that the Company shall
not be required to preserve any such right, license or franchise, or the
corporate, partnership or other existence of any of its Subsidiaries, if the
Board of Directors shall determine that the preservation thereof is no longer
desirable in the conduct of the business of the Company and its Subsidiaries,
taken as a whole, and that the loss thereof is not adverse in any material
respect to the Holders of the Notes.

SECTION 6.09.     OFFER TO REPURCHASE UPON REPURCHASE EVENT.

          (a)     Upon the occurrence of a Repurchase Event, the Company shall
                  make an offer (a "Repurchase Event Offer") to each Holder to
                  repurchase all or any part (equal to $1,000 or an integral
                  multiple thereof) of each Holder's Notes at a purchase price
                  equal to 100% of the aggregate principal amount thereof plus
                  accrued and unpaid interest and Additional Interest thereon,
                  if any, to, but excluding, the date of

<Page>

                  purchase (the "Repurchase Event Payment"). Within 10 business
                  days following any Repurchase Event, the Company shall mail a
                  notice to each Holder stating: (1) that the Repurchase Event
                  Offer is being made pursuant to this Section 6.09 and that all
                  Notes tendered will be accepted for payment; (2) the purchase
                  price and the purchase date, which shall be 30 business days
                  after the occurrence of a Repurchase Event (the "Repurchase
                  Event Payment Date"); (3) that any Note not tendered will
                  continue to accrue interest; (4) the name and address of each
                  Paying Agent and Conversion Agent; (5) the Conversion Price
                  and any adjustments thereto; (6) that Notes as to which a
                  Repurchase Event Payment Notice has been given may be
                  converted into Common Stock pursuant to Article 4 of this
                  Indenture only to the extent that the Repurchase Event Payment
                  Notice has been withdrawn in accordance with the terms of this
                  Indenture; (7) that, unless the Company defaults in the
                  payment of the Repurchase Event Payment, all Notes accepted
                  for payment pursuant to the Repurchase Event Offer shall cease
                  to accrue interest after the Repurchase Event Payment Date;
                  (8) that Holders electing to have any Notes purchased pursuant
                  to a Repurchase Event Offer will be required to surrender the
                  Notes, with the form entitled "Option of Holder to Elect
                  Purchase" set forth as an exhibit to the Notes completed, to
                  the Paying Agent at the address specified in the notice prior
                  to the close of business on the Business Day preceding the
                  Repurchase Event Payment Date; (9) that Holders will be
                  entitled to withdraw their election if the Paying Agent
                  receives, not later than the close of business on the Business
                  Day preceding the Repurchase Event Payment Date, a facsimile
                  transmission, letter or any other written form setting forth
                  the name of the Holder, the principal amount of Notes
                  delivered for purchase, and a statement that such Holder is
                  withdrawing his election to have the Notes purchased; and (10)
                  that Holders whose Notes are being purchased only in part will
                  be issued new Notes equal in principal amount to the
                  unpurchased portion of the Notes surrendered, which
                  unpurchased portion must be equal to $1,000 in principal
                  amount or an integral multiple thereof. The Company shall
                  comply with the requirements of Rule 13e-4 and Rule 14e-1
                  under the Exchange Act and any other securities laws and
                  regulations thereunder to the extent such laws and regulations
                  are applicable in connection with the repurchase of Notes in
                  connection with a Repurchase Event.

          A "Repurchase Event" shall be deemed to have occurred if any of the
following occurs after the date hereof:

                  (i)     any "person" or "group" (as such terms are defined
          below) is or  becomes  the  "beneficial  owner"  (as  defined  below),
          directly or indirectly  (other than as a direct result of  repurchases
          of stock by the  Company),  of shares of Voting  Stock of the  Company
          representing  50% or more of the total voting power of all outstanding
          classes of Voting Stock of the Company or such person or group has the
          power,  directly or indirectly,  to elect a majority of the members of
          the Board of Directors of the Company; or

                  (ii)    the Company consolidates with, or merges with or into,
          another Person or the Company sells, assigns, conveys, transfers,
          leases or otherwise disposes of all or

<Page>

          substantially all of the assets of the Company, or any Person
          consolidates with, or merges with or into, the Company, in any such
          event other than pursuant to a transaction in which the Persons that
          "beneficially owned" (as defined below), directly or indirectly,
          shares of Voting Stock of the Company immediately prior to such
          transaction "beneficially own" (as defined below), directly or
          indirectly, shares of Voting Stock of the Company representing at
          least a majority of the total voting power of all outstanding classes
          of Voting Stock of the surviving or transferee Person;

                  (iii)   there shall occur the liquidation or dissolution of
          the Company;

                  (iv)    Continuing Directors do not constitute a majority of
          the Board of Directors of the Company (or, if applicable, a successor
          corporation to the Company); or

                  (v)     the Common Stock (or other common stock into which the
          Notes are then convertible) is neither listed for trading on a United
          States national securities exchange nor approved for trading on an
          established automated over-the-counter trading market in the United
          States.

For the purpose of the definition of "Repurchase Event", (i) "person" and
"group" have the meanings given such terms under Section 13(d) and 14(d) of the
Exchange Act or any successor provision to either of the foregoing, and the term
"group" includes any group acting for the purpose of acquiring, holding or
disposing of securities within the meaning of Rule 13d-5(b)(1) under the
Exchange Act (or any successor provision thereto), (ii) a "beneficial owner"
shall be determined in accordance with Rule 13d-3 under the Exchange Act, as in
effect on the date of this Indenture, except that the number of shares of Voting
Stock of the Company shall be deemed to include, in addition to all outstanding
shares of Voting Stock of the Company and Unissued Shares deemed to be held by
the "person" or "group" (as such terms are defined above) or other Person with
respect to which the Repurchase Event determination is being made, all Unissued
Shares deemed to be held by all other Persons, and (iii) the terms "beneficially
owned" and "beneficially own" shall have meanings correlative to that of
"beneficial owner". The term "Unissued Shares" means shares of Voting Stock not
outstanding that are subject to options, warrants, rights to purchase or
conversion privileges exercisable within 60 days of the date of determination of
a Repurchase Event.

In addition, for the purpose of the definition of "REPURCHASE EVENT", the term
"CONTINUING DIRECTOR" means at any date a member of the Company's Board of
Directors (i) who was a member of such board on October 26, 2001 or (ii) who was
nominated or elected by at least a majority of the directors who were Continuing
Directors at the time of such nomination or election or whose election to the
Company's Board of Directors was recommended or endorsed by at least a majority
of the directors who were Continuing Directors at the time of such nomination or
election or such lesser number comprising a majority of a nominating committee
if authority for such nominations or elections has been delegated to a
nominating committee whose authority and composition have been approved by at
least a majority of the directors who were continuing directors at the time such
committee was formed. (Under this definition, if the Board of Directors of the
Company as of the date of this Indenture were to approve a new director or
directors and then resign, no Repurchase Event would occur even though the
current Board of Directors would thereafter cease to be in office).

<Page>

          Notwithstanding anything to the contrary set forth in this Section
6.09, a Repurchase Event will not be deemed to have occurred if either:

                  (i)     the Closing Sale Price of the Common Stock for any
          five trading days during the period of the ten trading days
          immediately preceding the Repurchase Event is at least equal to 105%
          of the Conversion Price in effect on such day; or

                  (ii)    in the case of a merger or consolidation, at least 90%
          of the consideration (excluding cash payments for fractional shares
          and cash payments made pursuant to dissenters' appraisal rights in
          connection with the merger or consolidation constituting the
          Repurchase Event) consists of common stock or American Depository
          Receipts traded on a United States national securities exchange or
          quoted on The Nasdaq National Market (or which will be so traded or
          quoted when issued or exchanged in connection with such Repurchase
          Event) and as a result of such transaction or transactions the Notes
          become convertible solely into such common stock or American
          Depository Receipts.

          (b)     A Holder may exercise its rights pursuant to this Section
6.09 upon delivery of a written notice (which shall be in substantially the form
entitled "Option to Elect Repurchase upon a Repurchase Event" set forth as an
exhibit to the Notes and which may be delivered by letter, overnight courier,
hand delivery, facsimile transmission or in any other written form and, in the
case of Global Notes, may be delivered electronically or by other means in
accordance with the Depositary's customary procedures) of the exercise of such
rights (a "REPURCHASE EVENT PAYMENT NOTICE") to any Paying Agent at any time
prior to the close of business on the Business Day next preceding the Repurchase
Event Purchase Date.

          Notwithstanding anything herein to the contrary, any Holder delivering
to a Paying Agent the Repurchase Event Payment Notice contemplated by this
Section 6.09(b) shall have the right to withdraw such Repurchase Event Payment
Notice in whole or in a portion thereof that is a principal amount of $1,000 or
in an integral multiple thereof at any time prior to the close of business on
the Business Day next preceding the Repurchase Event Payment Date by delivery of
a written notice of withdrawal to the Paying Agent in accordance with Section
6.09(a) hereof.

Upon receipt by any Paying Agent of the Repurchase Event Payment Notice
specified in this Section 6.09(b), the Holder of the Security in respect of
which such Repurchase Event Payment Notice was given shall (unless such
Repurchase Event Payment Notice is withdrawn as specified below) thereafter be
entitled to receive the Repurchase Event payment price, which may be paid in
cash, shares of Common Stock, or a combination thereof, with respect to such
Note. Such Repurchase Event payment price shall be paid to such Holder promptly
following the later of (i) the Repurchase Event Payment Date with respect to
such Note (provided the conditions in this Section 6.09(b) have been satisfied)
and (ii) the time of delivery of such Note to a Paying Agent by the Holder
thereof in the manner required by this Section 6.09(b). Notes in respect of
which a Repurchase Event Payment Notice has been given by the Holder thereof may
not be converted into shares of Common Stock on or after the date of the
delivery of such Repurchase Event Payment Notice unless such Repurchase Event
Payment Notice has first been validly withdrawn.

<Page>

          (c)     On the Repurchase Event Payment Date, the Company shall, to
the extent lawful, (1) accept for payment all Notes or portions thereof properly
tendered pursuant to the Repurchase Event Offer, (2) deposit with the Paying
Agent an amount of cash equal to the cash portion, if any, of the Repurchase
Event Payment in respect of all Notes or portions thereof so tendered and
deposit with the Paying Agent an amount of Common Stock equal to the Common
Stock portion, if any, of the Repurchase Event Payment in respect of all Notes
or portions thereof so tendered and (3) deliver or cause to be delivered to the
Trustee the Notes so accepted together with an Officers' Certificate stating the
aggregate principal amount of Notes or portions thereof being purchased by the
Company. The Paying Agent shall promptly mail to each Holder of Notes so
tendered cash payment in an amount equal to the cash portion of the purchase
price for the Notes and an amount of Common Stock equal to the Common Stock
portion of the purchase price for the Notes, and the Trustee shall promptly
authenticate and mail (or cause to be transferred by book entry) to each Holder
a new Note equal in principal amount to any unpurchased portion of the Notes
surrendered by such Holder, if any; provided, that each such new Note shall be
in a principal amount of $1,000 or an integral multiple thereof. Payments made
in Common Stock will be valued at 97% of the average closing sales prices of
Common Stock for the five trading days ending on the day prior to the Repurchase
Event Payment Date. The Company shall publicly announce the results of the
Repurchase Event Offer on or as soon as practicable after the Repurchase Event
Payment Date.

          If a Paying Agent holds, in accordance with the terms hereof, money
and shares of Common Stock sufficient to pay the Repurchase Event payment price
of any Note for which a Repurchase Event Payment Notice has been tendered and
not withdrawn in accordance with this Indenture then, on the Repurchase Event
Payment Date, such Note will cease to be outstanding and the rights of the
Holder in respect thereof shall terminate (other than the right to receive the
Repurchase Event payment price as aforesaid).

          (d)     Notwithstanding anything to the contrary in this Section 6.09,
the Company shall not be required to make a Repurchase Event Offer upon a
Repurchase Event if a third party makes the Repurchase Event Offer in the
manner, at the times and otherwise in compliance with the requirements set forth
in this Section 6.09 hereof and all other provisions of this Indenture
applicable to a Repurchase Event Offer made by the Company and purchases all
Notes validly tendered and not withdrawn under such Repurchase Event Offer.

SECTION 6.10.     PAYMENT OF ADDITIONAL INTEREST.

          If Additional Interest is payable by the Company pursuant to the
Registration Rights Agreement, the Company shall deliver to the Trustee a
certificate to that effect stating (i) the amount of such Additional Interest
that is payable and (ii) the date on which such Additional Interest is payable.
Unless and until a Trust Officer of the Trustee receives such a certificate, the
Trustee may assume without inquiry that no such Additional Interest is payable.
If the Company has paid Additional Interest directly to the Persons entitled to
it, the Company shall deliver to the Trustee a certificate setting forth the
particulars of such payment.

<Page>

                                   ARTICLE 7.
                                   SUCCESSORS

SECTION 7.01.     MERGER, CONSOLIDATION, OR SALE OF ASSETS.

          The Company shall not, directly or indirectly, consolidate or merge
with or into (whether or not the Company is the surviving corporation), or sell,
assign, transfer, convey or otherwise dispose of all or substantially all of its
properties or assets in one or more related transactions to, another Person
unless (i) the Company is the surviving corporation or the Person formed by or
surviving any such consolidation or merger (if other than the Company) or to
which such sale, assignment, transfer, conveyance or other disposition shall
have been made is a corporation or other entity (A) organized or existing under
the laws of the United States, any state thereof or the District of Columbia or
(B) organized and validly existing under the laws of a jurisdiction outside of
the United States of America, with its common stock, or American Depository
Receipts representing such shares of common stock, traded on a national
securities exchange in the United States of America or through Nasdaq, (ii) the
Person formed by or surviving any such consolidation or merger (if other than
the Company) or the Person to which such sale, assignment, transfer, conveyance
or other disposition shall have been made assumes all the obligations of the
Company under the Registration Rights Agreement, the Notes and this Indenture
pursuant to a supplemental indenture in a form reasonably satisfactory to the
Trustee, (iii) immediately after such transaction, no Default or Event of
Default exists and (iv) the Company or the surviving corporation, as the case
may be, shall have delivered to the Trustee and Officers' Certificate and an
Opinion of Counsel, each stating that such merger, consolidation, conveyance,
transfer or lease comply with this Article Seven and that all conditions
precedent herein provided for relating to such transaction have been satisfied.

SECTION 7.02.     SUCCESSOR CORPORATION SUBSTITUTED.

          Upon any consolidation or merger, or any sale, assignment, transfer,
lease, conveyance or other disposition of all or substantially all of the assets
of the Company in accordance with Section 7.01 hereof, the successor corporation
formed by such consolidation or into or with which the Company is merged or to
which such sale, assignment, transfer, lease, conveyance or other disposition is
made shall succeed to, and be substituted for (so that from and after the date
of such consolidation, merger, sale, lease, conveyance or other disposition, the
provisions of this Indenture referring to the "Company" shall refer instead to
the successor corporation and not to the Company), and may exercise every right
and power of the Company under this Indenture with the same effect as if such
successor Person had been named as the Company herein; PROVIDED, HOWEVER, that
the predecessor Company shall not be relieved from the obligation to pay the
principal of and interest on the Notes except in the case of a sale, assignment,
transfer, conveyance or other disposition of all of the Company's assets that
meets the requirements of Section 7.01 hereof.

                                   ARTICLE 8.
                              DEFAULTS AND REMEDIES

SECTION 8.01.     EVENTS OF DEFAULT.

<Page>

          An "Event of Default" occurs if:

          (a)     the Company defaults in the payment when due of interest on,
or Additional Interest with respect to, the Notes and such default continues for
a period of 30 days;

          (b)     the Company defaults in the payment when due of principal of
or premium, if any, on the Notes when the same becomes due and payable at
maturity, upon redemption (including in connection with an offer to purchase) or
otherwise;

          (c)     the Company fails to comply in any material respect with any
of the provisions of Section 6.09 hereof (including without limitation the
notice and payment provisions thereof); the Company fails to observe or perform
any other covenant, representation, warranty or other agreement in this
Indenture or the Notes for 45 days after notice to the Company by the Trustee or
the Holders of at least 25% in aggregate principal amount of the Notes then
outstanding voting as a single class;

          (d)     the Company fails to make any payment at maturity, including
any applicable grace period, in respect of Indebtedness, in an amount in excess
of $10,000,000, and such failure shall have continued for thirty (30) days after
written notice thereof shall have been given to the Company by the Trustee or to
the Company and a Responsible Officer of the Trustee by holders of not less than
25% in aggregate principal amount of the outstanding Notes, which notice
specifies such default and requires the Company to cause such default to be
cured or waived and states that such notice is a "Notice of Default" hereunder;

          (e)     the Company defaults with respect to any Indebtedness, which
default results in the acceleration of such Indebtedness in an amount in excess
of $10,000,000, without such Indebtedness having been discharged or such
acceleration having been cured, waived, rescinded or annulled for a period of
thirty (30) days after written notice thereof shall have been given to the
Company by the Trustee or to the Company and a Responsible Officer of the
Trustee by holders of not less than 25% in aggregate principal amount of the
outstanding Notes, which notice requires the Company to cause such Indebtedness
to be discharged or to cause such default to be cured or waived or such
acceleration to be rescinded or annulled and states that such notice is a
"Notice of Default" hereunder;

          (f)     the Company:  commences a voluntary  case,  consents to the
entry of an order for relief against it in an involuntary case, consents to the
appointment of a custodian of it or for all or substantially all of its
property, or makes a general assignment for the benefit of its creditors;

          (h)     a court of competent jurisdiction enters an order or decree
under any Bankruptcy Law that:

          (v)     is for relief against the Company in an involuntary case;

          (vi)    appoints a custodian of the Company or for all or
substantially all of the property of the Company; or

<Page>

          (vi)    orders the liquidation of the Company;

and the order or decree remains unstayed and in effect for 60 consecutive days.

SECTION 8.02.     ACCELERATION.

          If any Event of Default (other than an Event of Default specified in
clause (g) or (h) of Section 8.01 hereof with respect to the Company) occurs and
is continuing, the Trustee or the Holders of at least 25% in principal amount of
the then outstanding Notes may declare all the Notes to be due and payable
immediately. Upon any such declaration, the Notes shall become due and payable
immediately. Notwithstanding the foregoing, if an Event of Default specified in
clause (g) or (h) of Section 8.01 hereof occurs with respect to the Company, all
outstanding Notes shall be due and payable immediately without further action or
notice. The Holders of a majority in aggregate principal amount of the then
outstanding Notes by written notice to the Trustee may on behalf of all of the
Holders rescind an acceleration and its consequences if the rescission would not
conflict with any judgment or decree and if all existing Events of Default
(except nonpayment of principal, interest or premium that has become due solely
because of the acceleration) have been cured or waived.

SECTION 8.03.     OTHER REMEDIES.

          If an Event of Default occurs and is continuing, the Trustee may
pursue any available remedy to collect the payment of principal, premium, if
any, and interest on the Notes or to enforce the performance of any provision of
the Notes or this Indenture.

          The Trustee may maintain a proceeding even if it does not possess any
of the Notes or does not produce any of them in the proceeding. A delay or
omission by the Trustee or any Holder of a Note in exercising any right or
remedy accruing upon an Event of Default shall not impair the right or remedy or
constitute a waiver of or acquiescence in the Event of Default. All remedies are
cumulative to the extent permitted by law.

SECTION 8.04.     WAIVER OF PAST DEFAULTS.

          Subject to Section 8.02, Holders of not less than a majority in
aggregate principal amount of the then outstanding Notes by notice to the
Trustee may on behalf of the Holders of all of the Notes waive a past, present
or future Default or Event of Default and its consequences hereunder, except a
continuing Default or Event of Default in the payment of the principal of,
premium and Additional Interest, if any, or interest on, the Notes (including in
connection with an offer to purchase) or a failure by the Company to convert any
Notes into Common Stock (PROVIDED, HOWEVER, that the Holders of a majority in
aggregate principal amount of the then outstanding Notes may rescind an
acceleration and its consequences, including any related payment default that
resulted from such acceleration). Upon any such waiver, such Default shall cease
to exist, and any Event of Default arising therefrom shall be deemed to have
been cured for every purpose of this Indenture; but no such waiver shall extend
to any subsequent or other Default or impair any right consequent thereon.

<Page>

SECTION 8.05.     CONTROL BY MAJORITY.

          Holders of a majority in principal amount of the then outstanding
Notes may direct the time, method and place of conducting any proceeding for
exercising any remedy available to the Trustee or exercising any trust or power
conferred on it. However, the Trustee may refuse to follow any direction that
conflicts with law or this Indenture that the Trustee, in its sole discretion,
determines may be unduly prejudicial to the rights of other Holders of Notes or
that may involve the Trustee in personal liability.

SECTION 8.06.     LIMITATION ON SUITS.

          A Holder of a Note may pursue a remedy with respect to this Indenture
or the Notes only if:

          (a)     the Holder of a Note gives to the Trustee written notice of a
continuing Event of Default;

          (b)     the Holders of at least 25% in principal amount of the then
outstanding Notes make a written request to the Trustee to pursue the remedy;

         (c)      such Holder of a Note or Holders of Notes offer and, if
requested, provide to the Trustee indemnity satisfactory to the Trustee against
any loss, liability or expense;

          (d)     the Trustee does not comply with the request within 60 days
after receipt of the request and the offer and, if requested, the provision of
indemnity; and

          (e)     during such 60-day period the Holders of a majority in
principal amount of the then outstanding Notes do not give the Trustee a
direction inconsistent with the request.

          A Holder of a Note may not use this Indenture to prejudice the rights
of another Holder of a Note or to obtain a preference or priority over another
Holder of a Note.

SECTION 8.07.     RIGHTS OF HOLDERS OF NOTES TO RECEIVE PAYMENT.

          Notwithstanding any other provision of this Indenture, the right of
any Holder of a Note to receive payment of principal, premium and Additional
Interest, if any, and interest on the Note, on or after the respective due dates
expressed in the Note (including in connection with an offer to purchase), to
convert such Note in accordance with Article 4 or to bring suit for the
enforcement of any such payment on or after such respective dates, shall not be
impaired or affected without the consent of such Holder.

SECTION 8.08.     COLLECTION SUIT BY TRUSTEE.

         If an Event of Default specified in Section 8.01(a) or (b) occurs and
is continuing, the Trustee is authorized to recover judgment in its own name and
as trustee of an express trust

<Page>

against the Company for the whole amount of principal of, premium and Additional
Interest, if any, and interest remaining unpaid on the Notes and interest on
overdue principal and, to the extent lawful, interest and such further amount as
shall be sufficient to cover the costs and expenses of collection, including the
reasonable compensation, expenses, disbursements and advances of the Trustee,
its agents and counsel.

SECTION 8.09.     TRUSTEE MAY FILE PROOFS OF CLAIM.

          The Trustee is authorized to file such proofs of claim and other
papers or documents as may be necessary or advisable in order to have the claims
of the Trustee (including any claim for the reasonable compensation, expenses,
disbursements and advances of the Trustee, its agents and counsel) and the
Holders of the Notes allowed in any judicial proceedings relative to the Company
(or any other obligor upon the Notes), its creditors or its property and shall
be entitled and empowered to collect, receive and distribute any money or other
property payable or deliverable on any such claims and any custodian in any such
judicial proceeding is hereby authorized by each Holder to make such payments to
the Trustee, and in the event that the Trustee shall consent to the making of
such payments directly to the Holders, to pay to the Trustee any amount due to
it for the reasonable compensation, expenses, disbursements and advances of the
Trustee, its agents and counsel, and any other amounts due the Trustee under
Section 9.07 hereof. To the extent that the payment of any such compensation,
expenses, disbursements and advances of the Trustee, its agents and counsel, and
any other amounts due the Trustee under Section 9.07 hereof out of the estate in
any such proceeding, shall be denied for any reason, payment of the same shall
be secured by a lien on, and shall be paid out of, any and all distributions,
dividends, money, securities and other properties that the Holders may be
entitled to receive in such proceeding whether in liquidation or under any plan
of reorganization or arrangement or otherwise. Nothing herein contained shall be
deemed to authorize the Trustee to authorize or consent to or accept or adopt on
behalf of any Holder any plan of reorganization, arrangement, adjustment or
composition affecting the Notes or the rights of any Holder, or to authorize the
Trustee to vote in respect of the claim of any Holder in any such proceeding.

SECTION 8.10.     PRIORITIES.

          If the Trustee collects any money pursuant to this Article, it shall
pay out the money in the following order, subject to the provisions of Article
5:

                  FIRST:  to the Trustee, its agents and attorneys for amounts
          due under Section 9.07 hereof, including payment of all compensation,
          expense and liabilities incurred, and all advances made, by the
          Trustee and the costs and expenses of collection;

                  SECOND: to Holders of Notes for amounts due and unpaid on the
          Notes for principal, premium and Additional Interest, if any, and
          interest, ratably, without preference or priority of any kind,
          according to the amounts due and payable on the Notes for principal,
          premium and Additional Interest, if any and interest, respectively;
          and

<Page>

                  THIRD:  to the Company or to such party as a court of
          competent jurisdiction shall direct.

         The Trustee may fix a record date and payment date for any payment to
Holders of Notes pursuant to this Section 8.10.

SECTION 8.11.     UNDERTAKING FOR COSTS.

          In any suit for the enforcement of any right or remedy under this
Indenture or in any suit against the Trustee for any action taken or omitted by
it as a Trustee, a court in its discretion may require the filing by any party
litigant in the suit of an undertaking to pay the costs of the suit, and the
court in its discretion may assess reasonable costs, including reasonable
attorneys' fees and expenses, against any party litigant in the suit, having due
regard to the merits and good faith of the claims or defenses made by the party
litigant. This Section does not apply to a suit by the Trustee, a suit by a
Holder of a Note pursuant to Section 8.07 hereof, or a suit by Holders of more
than 10% in principal amount of the then outstanding Notes.

                                   ARTICLE 9.
                                    TRUSTEE
SECTION 9.01.     DUTIES OF TRUSTEE.

         (a)      If an Event of Default has occurred and is continuing, the
Trustee shall exercise such of the rights and powers vested in it by this
Indenture, and use the same degree of care and skill in its exercise, as a
prudent person would exercise or use under the circumstances in the conduct of
such person's own affairs.

         (b)      Except during the continuance of an Event of Default:

         (i)      the duties of the Trustee shall be determined solely by the
express provisions of this Indenture and the Trustee need perform only those
duties that are specifically set forth in this Indenture and no others, and no
implied covenants or obligations shall be read into this Indenture against the
Trustee; and

         (ii)     in the absence of bad faith on its part, the Trustee may
conclusively rely, as to the truth of the statements and the correctness of the
opinions expressed therein, upon certificates or opinions furnished to the
Trustee and conforming to the requirements of this Indenture. However, in the
case of any such certificates or opinions which by any provision hereof are
specifically required to be furnished to the Trustee, the Trustee shall be under
a duty to examine the same to determine whether or not they conform to the
requirements of this Indenture (but need not confirm or investigate the accuracy
of mathematical calculations or other facts stated therein).

          (c)     The Trustee may not be relieved from liabilities for its own
negligent action, its own negligent failure to act, or its own willful
misconduct, except that: this paragraph does not limit the effect of paragraph
(b) of this Section;

<Page>

          (i)     the Trustee shall not be liable for any error of judgment made
in good faith by a Responsible Officer, unless it is proved that the Trustee was
negligent in ascertaining the pertinent facts; and

          (j)     the Trustee shall not be liable with respect to any action it
takes or omits to take in good faith in accordance with a direction received by
it pursuant to Section 8.05 hereof.

         (d)      Whether or not therein expressly so provided, every provision
of this Indenture that in any way relates to the Trustee is subject to
paragraphs (a), (b), and (c) of this Section.

         (e)      No provision of this Indenture shall require the Trustee to
expend or risk its own funds or incur any liability.  The Trustee shall be under
no obligation  to exercise any of its rights and powers under this  Indenture at
the request of any Holders, unless such Holder shall have offered to the Trustee
security  and  indemnity  satisfactory  to it  against  any loss,  liability  or
expense.

         (f)      The Trustee shall not be liable for interest on any money
received  by it except as the  Trustee  may agree in writing  with the  Company.
Money held in trust by the  Trustee  need not be  segregated  from  other  funds
except to the extent required by law.

SECTION 9.02.     RIGHTS OF TRUSTEE.

          (a)     been signed or presented by the proper Person. The Trustee
need not investigate any fact or matter stated in the document.

          (b)     Before the Trustee acts or refrains from acting, it may
require an Officers' Certificate or an Opinion of Counsel or both. The Trustee
shall not be liable for any action it takes or omits to take in good faith in
reliance on such Officers' Certificate or Opinion of Counsel. The Trustee may
consult with counsel of its selection and the advice of such counsel or any
Opinion of Counsel shall be full and complete authorization and protection from
liability in respect of any action taken, suffered or omitted by it hereunder in
good faith and in reliance thereon.

          (c)     The Trustee may act through its attorneys and agents and shall
not be responsible for the misconduct or negligence of any agent appointed with
due care.

          (d)     The Trustee shall not be liable for any action it takes or
omits to take in good faith that it believes to be authorized or within the
rights or powers conferred upon it by this Indenture.

          (e)     Unless otherwise specifically provided in this Indenture, any
demand, request, direction or notice from the Company shall be sufficient if
signed by an Officer of the Company.

          (f)     The Trustee shall be under no obligation to exercise any of
the rights or powers vested in it by this Indenture at the request or direction
of any of the Holders unless such Holders

<Page>

shall have offered to the Trustee security or indemnity satisfactory to the
Trustee against the costs, expenses and liabilities that might be incurred by it
in compliance with such request or direction.

          (g)     The Trustee shall not be charged with knowledge of any Default
or Event of Default with respect to the Notes unless either (1) a Responsible
Officer shall have actual knowledge of such Default or Event of Default or (2)
written notice of such Default or Event of Default shall have been given to the
Trustee by the Company or any Holder of the Notes.

          (h)     The rights, privileges, protections, immunities and benefits
given to the Trustee, including, without limitation, its right to be
indemnified, are extended to, and shall be enforceable by, the Trustee in each
of its capacities hereunder, and each agent, custodian and other Person employed
to act hereunder.

          (i)     The Trustee may request that the Company deliver an Officers'
Certificate setting forth the names of individuals and/or titles of officers
authorized at such time to take specified actions pursuant to this Indenture,
which Officers' Certificate may be signed by any person authorized to sign an
Officers' Certificate, including any person specified as so authorized in any
such certificate previously delivered and not superseded.

SECTION 9.03.     INDIVIDUAL RIGHTS OF TRUSTEE.

          The Trustee in its individual or any other capacity may become the
owner or pledgee of Notes and may otherwise deal with the Company or any
Affiliate of the Company with the same rights it would have if it were not
Trustee. However, in the event that the Trustee acquires any conflicting
interest it must eliminate such conflict within 90 days, apply to the SEC for
permission to continue as trustee or resign. Any Agent may do the same with like
rights and duties. The Trustee is also subject to Sections 9.10 and 9.11 hereof.

SECTION 9.04.     TRUSTEE'S DISCLAIMER.

          The Trustee shall not be responsible for and makes no representation
as to the validity or adequacy of this Indenture or the Notes, it shall not be
accountable for the Company's use of the proceeds from the Notes or any money
paid to the Company or upon the Company's direction under any provision of this
Indenture, it shall not be responsible for the use or application of any money
received by any Paying Agent other than the Trustee, and it shall not be
responsible for any statement or recital herein or any statement in the Notes or
any other document in connection with the sale of the Notes or pursuant to this
Indenture other than its certificate of authentication.

SECTION 9.05.     NOTICE OF DEFAULTS.

          If a Default or Event of Default occurs and is continuing and if it is
known to the Trustee, the Trustee shall mail to Holders of Notes a notice of the
Default or Event of Default within 90 days after it occurs. Except in the case
of a Default or Event of Default in payment of principal of, premium, if any, or
interest on any Note, the Trustee may withhold the notice if and so long

<Page>

as a committee of its Responsible Officers in good faith determines that
withholding the notice is in the interests of the Holders of the Notes.

SECTION 9.06.     REPORTS BY TRUSTEE TO HOLDERS OF THE NOTES.

          Within 60 days after each May 15  beginning  with the May 15 following
the date of this  Indenture,  and for so long as Notes remain  outstanding,  the
Trustee  shall mail to the Holders of the Notes a brief  report dated as of such
reporting date that complies with TIA Section 313(a) (but if no event  described
in TIA  Section  313(a) has  occurred  within the twelve  months  preceding  the
reporting  date, no report need be  transmitted).  The Trustee also shall comply
with TIA Section 313(b)(2).  The Trustee shall also transmit by mail all reports
as required by TIA Section 313(c).

          A copy of each  report at the time of its  mailing  to the  Holders of
Notes  shall be mailed to the  Company  and  filed  with the SEC and each  stock
exchange on which the Notes are listed in  accordance  with TIA Section  313(d).
The Company shall  promptly  notify the Trustee when the Notes are listed on any
stock exchange and of any delisting thereof.

SECTION 9.07.     COMPENSATION AND INDEMNITY.

          The Company shall pay to the Trustee from time to time such
compensation as shall be agreed in writing between the Company and the Trustee
for its acceptance of this Indenture and services hereunder. The Trustee's
compensation shall not be limited by any law on compensation of a trustee of an
express trust. The Company shall reimburse the Trustee promptly upon request for
all reasonable disbursements, advances and expenses incurred or made by it in
addition to the compensation for its services. Such expenses shall include the
reasonable compensation, disbursements and expenses of the Trustee's agents and
counsel.

The Company  shall  indemnify  each of the Trustee and any  predecessor  Trustee
against any and all losses, liabilities, damages, claims or expenses incurred by
it arising out of or in connection with the acceptance or  administration of its
duties under this  Indenture,  including the costs and expenses  including taxes
(other  than taxes based upon,  measured by or  determined  by the income of the
Trustee),  of  enforcing  this  Indenture  against the Company  (including  this
Section 9.07) and defending  itself against any claim  (whether  asserted by the
Company or any Holder or any other person) or liability in  connection  with the
exercise or performance of any of its powers or duties hereunder,  except to the
extent any such loss, liability or expense may be attributable to its negligence
or bad faith.  The Trustee  shall  notify the Company  promptly of any claim for
which it may seek  indemnity.  Failure by the  Trustee to so notify the  Company
shall not relieve the Company of its  obligations  hereunder.  The Company shall
defend the claim and the Trustee shall cooperate in the defense. The Trustee may
have separate counsel and the Company shall pay the reasonable fees and expenses
of such counsel.  The Company need not pay for any  settlement  made without its
consent, which consent shall not be unreasonably withheld.

          The obligations of the Company under this Section 9.07 shall survive
the resignation or removal of the Trustee and the satisfaction and discharge of
this Indenture.

<Page>

          To secure the Company's payment obligations in this Section, the
Trustee shall have a lien prior to the Notes on all money or property held or
collected by the Trustee, except that held in trust to pay principal and
interest on particular Notes. Such lien shall survive the satisfaction and
discharge of this Indenture.

          When the Trustee incurs expenses or renders services after an Event of
Default specified in Section 8.01(g) or (h) hereof occurs, the expenses and the
compensation for the services (including the fees and expenses of its agents and
counsel) are intended to constitute expenses of administration under any
Bankruptcy Law.

          The Trustee shall comply with the provisions of TIA Section  313(b)(2)
to the extent applicable.

SECTION 9.08.     REPLACEMENT OF TRUSTEE.

          A resignation or removal of the Trustee and appointment of a successor
Trustee shall become effective only upon the successor Trustee's acceptance of
appointment as provided in this Section.

          The Trustee may resign in writing at any time and be discharged from
the trust hereby created by so notifying the Company. The Holders of a majority
in principal amount of the then outstanding Notes may remove the Trustee by so
notifying the Trustee and the Company in writing. The Company may remove the
Trustee if:

          (a)     the Trustee fails to comply with Section 9.10 hereof;

          (b)     the Trustee is adjudged a bankrupt or an insolvent or an order
for relief is entered with respect to the Trustee under any Bankruptcy Law;

          (c)     a custodian or public officer takes charge of the Trustee or
its property; or the Trustee becomes incapable of acting.

          (d)     If the Trustee resigns or is removed or if a vacancy exists in
the office of Trustee for any reason, the Company shall promptly appoint a
successor Trustee. Within one year after the successor Trustee takes office, the
Holders of a majority in principal amount of the then outstanding Notes may
appoint a successor Trustee to replace the successor Trustee appointed by the
Company.

          If a successor Trustee does not take office within 60 days after the
retiring Trustee resigns or is removed, the retiring Trustee, the Company, or
the Holders of at least 10% in principal amount of the then outstanding Notes
may petition, at the expense of the Company, any court of competent jurisdiction
for the appointment of a successor Trustee.

          If the Trustee, after written request by any Holder who has been a
Holder for at least six months, fails to comply with Section 9.10, such Holder
may petition any court of competent jurisdiction for the removal of the Trustee
and the appointment of a successor Trustee.

<Page>

          A successor Trustee shall deliver a written acceptance of its
appointment to the retiring Trustee and to the Company. Thereupon, the
resignation or removal of the retiring Trustee shall become effective, and the
successor Trustee shall have all the rights, powers and duties of the Trustee
under this Indenture. The successor Trustee shall mail a notice of its
succession to Holders. The retiring Trustee shall promptly transfer all property
held by it as Trustee to the successor Trustee, PROVIDED all sums owing to the
Trustee hereunder have been paid and subject to the Lien provided for in Section
9.07 hereof. Notwithstanding replacement of the Trustee pursuant to this Section
9.08, the Company's obligations under Section 9.07 hereof shall continue for the
benefit of the retiring Trustee.

SECTION 9.09.     SUCCESSOR TRUSTEE BY MERGER, ETC.

          If the Trustee consolidates, merges or converts into, or transfers all
or substantially all of its corporate trust business to, another corporation,
the successor corporation without any further act shall be the successor
Trustee.

SECTION 9.10.     ELIGIBILITY; DISQUALIFICATION.

          There shall at all times be a Trustee hereunder that is a corporation
organized and doing business under the laws of the United States of America or
of any state thereof that is authorized under such laws to exercise corporate
trustee power, that is subject to supervision or examination by federal or state
authorities and that has a combined capital and surplus of at least $50 million
as set forth in its most recent published annual report of condition.

          This  Indenture   shall  always  have  a  Trustee  who  satisfies  the
requirements  of TIA Section  310(a)(1),  (2) and (5). The Trustee is subject to
TIA Section 310(b).

SECTION 9.11.     PREFERENTIAL COLLECTION OF CLAIMS AGAINST COMPANY.

          The Trustee is subject to TIA Section 311(a), excluding any creditor
relationship listed in TIA Section 311(b). A Trustee who has resigned or been
removed shall be subject to TIA Section 311(a) to the extent indicated therein.

                                   ARTICLE 10.
                           SATISFACTION AND DISCHARGE
SECTION 10.01. SATISFACTION AND DISCHARGE.

          This Indenture will be discharged and will cease to be of further
effect as to all Notes issued hereunder, when:

(1)       either:

<Page>

          (a)     all Notes that have been authenticated (except lost, stolen or
                  destroyed Notes that have been replaced or paid and Notes for
                  whose payment money has theretofore been deposited in trust
                  and thereafter repaid to the Company) have been delivered to
                  the Trustee for cancellation; or

          (b)     all Notes that have not been delivered to the Trustee for
                  cancellation have become due and payable by reason of the
                  making of a notice of redemption or otherwise or will become
                  due and payable within one year and the Company has
                  irrevocably deposited or caused to be deposited with the
                  Trustee as trust funds in trust solely for the benefit of the
                  Holders, cash in U.S. dollars, non-callable Government
                  Securities, or a combination thereof, in such amounts as will
                  be sufficient, in the opinion of an independent firm of
                  certified public accountants (which opinion shall not be
                  required in the event that such trust funds consist solely of
                  cash in U.S. dollars), without consideration of any
                  reinvestment of interest, to pay and discharge the entire
                  indebtedness on the Notes not delivered to the Trustee for
                  cancellation for principal, premium and Additional Interest,
                  if any, and accrued interest to the date of maturity or
                  redemption;

(2)       no Default or Event of Default shall have occurred and be continuing
          on the date of such deposit or shall occur as a result of such deposit
          and such deposit will not result in a breach or violation of, or
          constitute a default under, any other instrument to which the Company
          is a party or by which the Company is bound;

(3)       the Company has paid or caused to be paid all sums payable by it under
          this Indenture; and

(4)       the Company has delivered irrevocable instructions to the Trustee
          under this Indenture to apply the deposited money toward the payment
          of the Notes at maturity or the redemption date, as the case may be.

          In addition, the Company must deliver an Officers' Certificate and an
Opinion of Counsel to the Trustee stating that all conditions precedent to
satisfaction and discharge have been satisfied.

          The Company shall pay and indemnify the Trustee against any tax, fee
or other charge imposed on or assessed against the Government Securities
deposited pursuant to this section or the principal and interest received in
respect thereof other than any such tax, fee or other charge which by law is for
the account of the Holders of outstanding Notes.

          Notwithstanding the satisfaction and discharge of this Indenture, if
money shall have been deposited with the Trustee pursuant to subclause (b) of
clause (1) of this Section, the provisions of Section 10.02 shall survive.

SECTION 10.02.    APPLICATION OF TRUST MONEY.

          All money deposited with the Trustee pursuant to Section 10.01 shall
be held in trust and applied by it, in accordance with the provisions of the
Notes and this Indenture, to the payment,

<Page>

either directly or through any Paying Agent (including the Company acting as its
own Paying Agent) as the Trustee may determine, to the Persons entitled thereto,
of the principal (and premium, if any) and interest for whose payment such money
has been deposited with the Trustee; but such money need not be segregated from
other funds except to the extent required by law.

          If the Trustee or Paying Agent is unable to apply any money or
Government Securities in accordance with Section 10.01 by reason of any legal
proceeding or by reason of any order or judgment of any court or governmental
authority enjoining, restraining or otherwise prohibiting such application, the
Company's obligations under this Indenture and the Notes shall be revived and
reinstated as though no deposit had occurred pursuant to Section 10.01; PROVIDED
that if the Company has made any payment of principal of, premium, if any, or
interest on any Notes because of the reinstatement of its obligations, the
Company shall be subrogated to the rights of the Holders of such Notes to
receive such payment from the money or Government Securities held by the Trustee
or Paying Agent.

SECTION 10.03.    REPAYMENT TO COMPANY.

          The Trustee and each Paying Agent shall promptly pay to the Company
upon written request any excess money (i) deposited with them pursuant to
Section 10.1 and (ii) held by them at any time.

          The Trustee and each Paying Agent shall pay to the Company upon
request any money held by them for the payment of principal or interest that
remains unclaimed for two years after a right to such money has matured;
PROVIDED, HOWEVER, that the Trustee or such Paying Agent, before being required
to make any such payment, shall at the expense of the Company cause to be mailed
to each Holder entitled to such money notice that such money remains unclaimed
and that after a date specified therein, which shall be at least 30 days from
the date of such mailing, any unclaimed balance of such money then remaining
will be repaid to the Company. After payment to the Company, Holders entitled to
money must look to the Company for payment as general creditors.

SECTION 10.04.    REINSTATEMENT.

          If the Trustee or any Paying Agent is unable to apply any money in
accordance with Section 10.2 by reason of any legal proceeding or by reason of
any order or judgment of any court or governmental authority enjoining,
restraining or otherwise prohibiting such application, then the Company's
obligations under this Indenture and the Notes shall be revived and reinstated
as though no deposit had occurred pursuant to Section 10.1 until such time as
the Trustee or such Paying Agent is permitted to apply all such money in
accordance with Section 10.2; PROVIDED, HOWEVER, that if the Company has made
any payment of the principal of or interest on any Notes because of the
reinstatement of its obligations, the Company shall be subrogated to the rights
of the Holders of such Notes to receive any such payment from the money held by
the Trustee or such Paying Agent.

<Page>

                                   ARTICLE 11.
                        AMENDMENT, SUPPLEMENT AND WAIVER

SECTION 11.01.    WITHOUT CONSENT OF HOLDERS OF NOTES.

          Notwithstanding Section 11.02 of this Indenture, the Company and the
Trustee may amend or supplement this Indenture or the Notes without the consent
of any Holder of a Note:

          (a)     to cure any ambiguity, defect or inconsistency;

          (b)     to provide for uncertificated Notes in addition to or in place
of certificated Notes or to alter the provisions of Article 2 hereof (including
the related definitions) in a manner that does not materially adversely affect
any Holder;

          (c)     to provide for the assumption of the Company's  obligations to
the Holders of the Notes by a successor to the Company pursuant to Article 7
hereof;

          (d)     to make any change that would provide any additional rights or
benefits to the Holders of the Notes or that does not adversely affect the legal
rights hereunder of any Holder of the Note;

          (e)     to comply with requirements of the SEC in order to effect or
maintain the qualification of this Indenture under the TIA;

          (f)     to provide for the issuance of additional Notes pursuant to
the purchasers option set forth in the Purchase Agreement.

          (g)     to appoint a successor trustee; or

          (h)     to cure any ambiguity, defect or inconsistency under this
Indenture or the Notes.

          Upon the request of the Company accompanied by a resolution of its
Board of Directors authorizing the execution of any such amended or supplemental
Indenture, and upon receipt by the Trustee of the documents described in Section
9.02 hereof, the Trustee shall join with the Company in the execution of any
amended or supplemental Indenture authorized or permitted by the terms of this
Indenture and to make any further appropriate agreements and stipulations that
may be therein contained, but the Trustee shall not be obligated to enter into
such amended or supplemental Indenture that affects its own rights, duties or
immunities under this Indenture or otherwise.

SECTION 11.02.    WITH CONSENT OF HOLDERS OF NOTES.

          Except as provided below in this Section 11.02, the Company and the
Trustee may amend or supplement this Indenture (including Section 6.09 hereof)
and the Notes with the consent of

<Page>

the Holders of at least a majority in principal amount of the Notes then
outstanding voting as a single class (including consents obtained in connection
with a tender offer or exchange offer for, or purchase of, the Notes), and,
subject to Sections 8.04 and 8.07 hereof, any existing Default or Event of
Default (other than a Default or Event of Default in the payment of the
principal of, premium, if any, or interest on the Notes, except a payment
default resulting from an acceleration that has been rescinded) or compliance
with any provision of this Indenture or the Notes may be waived with the consent
of the Holders of a majority in principal amount of the then outstanding Notes
voting as a single class (including consents obtained in connection with a
tender offer or exchange offer for, or purchase of, the Notes). Section 2.08
hereof shall determine which Notes are considered to be "outstanding" for
purposes of this Section 11.02.

          Upon the request of the Company accompanied by a resolution of its
Board of Directors authorizing the execution of any such amended or supplemental
Indenture, and upon the filing with the Trustee of evidence satisfactory to the
Trustee of the consent of the Holders of Notes as aforesaid, and upon receipt by
the Trustee of the documents described in Section 9.02 hereof, the Trustee shall
join with the Company in the execution of such amended or supplemental Indenture
unless such amended or supplemental Indenture directly affects the Trustee's own
rights, duties or immunities under this Indenture or otherwise, in which case
the Trustee may in its discretion, but shall not be obligated to, enter into
such amended or supplemental Indenture.

          It shall not be necessary for the consent of the Holders of Notes
under this Section 11.02 to approve the particular form of any proposed
amendment or waiver, but it shall be sufficient if such consent approves the
substance thereof.

          After an amendment, supplement or waiver under this Section becomes
effective, the Company shall mail to the Holders of Notes affected thereby a
notice briefly describing the amendment, supplement or waiver. Any failure of
the Company to mail such notice, or any defect therein, shall not, however, in
any way impair or affect the validity of any such amended or supplemental
Indenture or waiver. Subject to Sections 8.04 and 8.07 hereof, the Holders of a
majority in aggregate principal amount of the Notes then outstanding voting as a
single class may waive compliance in a particular instance by the Company with
any provision of this Indenture or the Notes. However, without the consent of
each Holder affected, an amendment or waiver under this Section 11.02 may not
(with respect to any Notes held by a non-consenting Holder):

          (a)     reduce the principal amount of Notes whose Holders must
consent to an amendment, supplement or waiver;

          (b)     reduce the principal of or change the fixed maturity of any
Note or alter or waive any of the provisions with respect to the redemption of
the Notes except as provided above with respect to Section 6.09 hereof;

          (c)     reduce the rate of or change the time for payment of interest,
including default interest, on any Note;

          (d)     waive a Default or Event of Default in the payment of
principal of or premium, if any, or interest on the Notes (except a rescission
of acceleration of the Notes by the Holders of at

<Page>

least a majority in aggregate principal amount of the then outstanding Notes and
a waiver of the payment default that resulted from such acceleration);

          (e)     make any Note payable in money other than that stated in the
Notes;

          (f)     make any change in the provisions of this Indenture relating
to waivers of past Defaults or the rights of Holders of Notes to receive
payments of principal of or interest on the Notes; or

          (g)     make any change in Section 8.04 or 8.07 hereof or in the
foregoing amendment and waiver provisions.

SECTION 11.03.    COMPLIANCE WITH TRUST INDENTURE ACT.

          Every amendment or supplement to this Indenture or the Notes shall be
set forth in a amended or supplemental Indenture that complies with the TIA as
then in effect.

SECTION 11.04.    REVOCATION AND EFFECT OF CONSENTS.

          Until an amendment, supplement or waiver becomes effective, a consent
to it by a Holder of a Note is a continuing consent by the Holder of a Note and
every subsequent Holder of a Note or portion of a Note that evidences the same
debt as the consenting Holder's Note, even if notation of the consent is not
made on any Note. However, any such Holder of a Note or subsequent Holder of a
Note may revoke the consent as to its Note if the Trustee receives written
notice of revocation before the date the waiver, supplement or amendment becomes
effective. An amendment, supplement or waiver becomes effective in accordance
with its terms and thereafter binds every Holder.

SECTION 11.05.    NOTATION ON OR EXCHANGE OF NOTES.

          The Trustee may place an appropriate notation about an amendment,
supplement or waiver on any Note thereafter authenticated. The Company in
exchange for all Notes may issue and the Trustee shall, upon receipt of an
Authentication Order, authenticate new Notes that reflect the amendment,
supplement or waiver.

          Failure to make the appropriate notation or issue a new Note shall not
affect the validity and effect of such amendment, supplement or waiver.

SECTION 11.06.    TRUSTEE TO SIGN AMENDMENTS, ETC.

          The Trustee shall sign any amended or supplemental Indenture
authorized pursuant to this Article Nine if the amendment or supplement does not
adversely affect the rights, duties, liabilities or immunities of the Trustee.
The Company may not sign an amendment or supplemental Indenture until the Board
of Directors approves it. In executing any amended or supplemental indenture,
the Trustee shall be entitled to receive and (subject to Section 9.01

<Page>

hereof) shall be fully protected in relying upon, in addition to the documents
required by Section 12.04 hereof, an Officer's Certificate and an Opinion of
Counsel stating that the execution of such amended or supplemental indenture is
authorized or permitted by this Indenture.

                                   ARTICLE 12.
                                  MISCELLANEOUS

SECTION 12.01.    TRUST INDENTURE ACT CONTROLS.

          If any provision of this Indenture limits, qualifies or conflicts with
the duties imposed by TIA Section 318(c), the imposed duties shall control.

SECTION 12.02.    NOTICES.

          Any notice or communication by the Company or the Trustee to the
others is duly given if in writing and delivered in Person or mailed by first
class mail (registered or certified, return receipt requested), telex,
telecopier or overnight air courier guaranteeing next day delivery, to the
others' address:

          If to the Company:

          Cubist Pharmaceuticals, Inc.
          65 Hayden Avenue
          Lexington, Massachusetts 02421
          Telecopier No.:  (781) 861-1150
          Attention:  Chief Financial Officer

          With copy to:
          Bingham Dana LLP
          Telecopier No.:  (617) 951-8736
          Attention:  Julio E. Vega, Esq. And Matthew J. Cushing, Esq.

          If to the Trustee:

          The Bank of New York
          101 Barclay Street, 21st Floor West
          New York, New York 10286
          Telecopier No.:  (212) 896-7298
          Attention:  Corporate Trust Administration

          The Company or the Trustee, by notice to the others may designate
additional or different addresses for subsequent notices or communications.

<Page>

          All notices and communications (other than those sent to Holders)
shall be deemed to have been duly given: at the time delivered by hand, if
personally delivered; five Business Days after being deposited in the mail,
postage prepaid, if mailed; when answered back, if telexed; when receipt
acknowledged, if telecopied; and the next Business Day after timely delivery to
the courier, if sent by overnight air courier guaranteeing next day delivery.

          Any notice or communication to a Holder shall be mailed by first class
mail,  certified or registered,  return receipt  requested,  or by overnight air
courier guaranteeing next day delivery to its address shown on the register kept
by the  Registrar.  Any notice or  communication  shall also be so mailed to any
Person  described  in TIA  Section  313(c),  to the extent  required by the TIA.
Failure to mail a notice or  communication to a Holder or any defect in it shall
not affect its sufficiency with respect to other Holders.

          If a notice or communication is mailed in the manner provided above
within the time prescribed, it is duly given, whether or not the addressee
receives it.

          If the Company mails a notice or communication to Holders, it shall
mail a copy to the Trustee and each Agent at the same time.

SECTION 12.03.    COMMUNICATION BY HOLDERS OF NOTES WITH OTHER HOLDERS OF NOTES.

          Holders may  communicate  pursuant  to TIA  Section  312(b) with other
Holders  with respect to their  rights  under this  Indenture or the Notes.  The
Company, the Trustee, the Registrar and anyone else shall have the protection of
TIA Section 312(c).

SECTION 12.04.    CERTIFICATE AND OPINION AS TO CONDITIONS PRECEDENT.

          Upon any request or application by the Company to the Trustee to take
any action under this Indenture, the Company shall furnish to the Trustee:

          (a) an Officers' Certificate in form and substance reasonably
satisfactory to the Trustee (which shall include the statements set forth in
Section 12.05 hereof) stating that, in the opinion of the signers, all
conditions precedent and covenants, if any, provided for in this Indenture
relating to the proposed action have been satisfied; and

          (b) an Opinion of Counsel in form and substance reasonably
satisfactory to the Trustee (which shall include the statements set forth in
Section 12.05 hereof) stating that, in the opinion of such counsel, all such
conditions precedent and covenants have been satisfied.

SECTION 12.05.    STATEMENTS REQUIRED IN CERTIFICATE OR OPINION.

          Each  certificate  or  opinion  with  respect  to  compliance  with  a
condition or covenant  provided for in this Indenture  (other than a certificate
provided pursuant to TIA Section  314(a)(4)) shall comply with the provisions of
TIA Section 314(e) and shall include:

          (a)     a statement that the Person making such certificate or opinion
has read such covenant or condition;

<Page>

          (b)     a brief statement as to the nature and scope of the
examination or investigation upon which the statements or opinions contained in
such certificate or opinion are based;

          (c)     a statement that, in the opinion of such Person, he or she has
made such examination or investigation as is necessary to enable him to express
an informed opinion as to whether or not such covenant or condition has been
satisfied; and

          (d)     statement as to whether or not, in the opinion of such Person,
such condition or covenant has been satisfied.

SECTION 12.06.    RULES BY TRUSTEE AND AGENTS.

          The Trustee may make reasonable rules for action by or at a meeting of
Holders. The Registrar or Paying Agent may make reasonable rules and set
reasonable requirements for its functions.

SECTION 12.07.    NO PERSONAL LIABILITY OF DIRECTORS, OFFICERS, EMPLOYEES AND
STOCKHOLDERS.

          No past, present or future director, officer, employee, incorporator
or stockholder of the Company, as such, shall have any liability for any
obligations of the Company under the Notes, this Indenture or for any claim
based on, in respect of, or by reason of, such obligations or their creation.
Each Holder by accepting a Note waives and releases all such liability. The
waiver and release are part of the consideration for issuance of the Notes.

SECTION 12.08.    GOVERNING LAW.

          THE INTERNAL LAW OF THE STATE OF NEW YORK SHALL GOVERN AND BE USED TO
CONSTRUE THIS INDENTURE, THE NOTES WITHOUT GIVING EFFECT TO APPLICABLE
PRINCIPLES OF CONFLICTS OF LAW TO THE EXTENT THAT THE APPLICATION OF THE LAWS OF
ANOTHER JURISDICTION WOULD BE REQUIRED THEREBY.

SECTION 12.09.    NO ADVERSE INTERPRETATION OF OTHER AGREEMENTS.

This Indenture may not be used to interpret any other indenture, loan or debt
agreement of the Company or its Subsidiaries or of any other Person. Any such
indenture, loan or debt agreement may not be used to interpret this Indenture.

SECTION 12.10.    SUCCESSORS.

All agreements of the Company in this Indenture and the Notes shall bind its
successors. All agreements of the Trustee in this Indenture shall bind its
successors.

SECTION 12.11.    SEVERABILITY.

<Page>

In case any provision in this Indenture or in the Notes shall be invalid,
illegal or unenforceable, the validity, legality and enforceability of the
remaining provisions shall not in any way be affected or impaired thereby.

SECTION 12.12.    COUNTERPART ORIGINALS.

The parties may sign any number of copies of this Indenture. Each signed copy
shall be an original, but all of them together represent the same agreement.

SECTION 12.13.    TABLE OF CONTENTS, HEADINGS, ETC.

          The Table of Contents, Cross-Reference Table and Headings of the
Articles and Sections of this Indenture have been inserted for convenience of
reference only, are not to be considered a part of this Indenture and shall in
no way modify or restrict any of the terms or provisions hereof.

                         [Signatures on following page]

<Page>

                                   SIGNATURES

Dated as of October 26, 2001

                                        Cubist Pharmaceuticals, Inc.

                                        By: /s/ Thomas A. Shea
                                            ------------------------------------
                                            Name: Thomas A. Shea
                                            Title: Chief Financial Officer

                                        THE BANK OF NEW YORK,
                                        as Trustee

                                        By: /s/ Kisha Holder
                                            ------------------------------------
                                            Name: Kisha Holder
                                            Title: Assistant Treasurer

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