Document:

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EXHIBIT 10.79

                               SECURITY AGREEMENT

         THIS SECURITY AGREEMENT (the "AGREEMENT"), is entered into and made
effective as of July 18, 2003, by and between ADVANCED VIRAL RESEARCH CORP. (the
"COMPANY"), and the BUYER(S) listed on Schedule I attached to the Securities
Purchase Agreement dated the date hereof (the "SECURED PARTY").

         WHEREAS, the Company shall issue and sell to the Secured Party, as
provided in the Securities Purchase Agreement dated the date hereof, and the
Secured Party shall purchase up to One Million Dollars ($1,000,000) of five
percent (5%) secured convertible debentures (the "CONVERTIBLE DEBENTURES"),
which shall be convertible into shares of the Company's common stock, par value
$0.00001 (the "COMMON STOCK") (as converted, the "CONVERSION SHARES"), for a
total purchase price of up to One Million Dollars ($1,000,000), in the
respective amounts set forth opposite each Buyer(s) name on Schedule I attached
to the Securities Purchase Agreement;

         WHEREAS, to induce the Secured Party to enter into the transaction
contemplated by the Securities Purchase Agreement, the Secured Convertible
Debenture, the Investor Registration Rights Agreement, the Irrevocable Transfer
Agent Instructions, and the Escrow Agreement (collectively referred to as the
"TRANSACTION DOCUMENTS"), the Company hereby grants to the Secured Party a
security interest in and to the pledged property identified on EXHIBIT "A"
hereto (collectively referred to as the "PLEDGED PROPERTY") until the earlier to
occur of (i) the fiftieth (50th) day following the effectiveness of the
Registration Statement referred to in the Investor Registration Rights
Agreement, pursuant to the terms and conditions of this Agreement; (ii) the
Company receives, after the date of this Agreement, Three Million Dollars
($3,000,000) of capital, in any form other than through the issuance of
free-trading shares of the Company's common stock, from sources other than the
Secured Party ("Capital Raise"); or (iii) satisfaction of the Obligations, as
defined herein below ((i), (ii) and (ii) are sometimes hereinafter individually
referred to as an "EXPIRATION Event").

         NOW, THEREFORE, in consideration of the premises and the mutual
covenants herein contained, and for other good and valuable consideration, the
adequacy and receipt of which are hereby acknowledged, the parties hereto hereby
agree as follows:

                                   ARTICLE 1.

                         DEFINITIONS AND INTERPRETATIONS

         Section 1.1. RECITALS.

         The above recitals are true and correct and are incorporated herein, in
their entirety, by this reference.

         Section 1.2. INTERPRETATIONS.

         Nothing herein expressed or implied is intended or shall be construed
to confer upon any person other than the Secured Party any right, remedy or
claim under or by reason hereof.

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         Section 1.3. OBLIGATIONS SECURED.

         The obligations secured hereby are any and all obligations of the
Company to the Secured Party, whether oral or written and whether arising
before, on or after the date hereof including, without limitation, those
obligations of the Company to the Secured Party under the Securities Purchase
Agreement, the Secured Convertible Debenture, the Investor Registration Rights
Agreement and Irrevocable Transfer Agent Instructions, in the principal amounts
thereof outstanding from time to time, and any other amounts payable by or
chargeable to the Company thereunder or hereunder (collectively, the
"OBLIGATIONS"), PROVIDED, HOWEVER, the Scheduled Effective Deadline set forth in
the Investor Registration Rights Agreement dated April 28, 2003 shall be one
hundred thirty-five (135) days from the date hereof.

                                   ARTICLE 2.

              PLEDGED COLLATERAL, ADMINISTRATION OF COLLATERAL AND
                        TERMINATION OF SECURITY INTEREST

         Section 2.1. PLEDGED PROPERTY.

                  (a) Company hereby pledges to the Secured Party, and creates
in the Secured Party for its benefit, a security interest, from the date hereof
through an Expiration Event, in and to all of the property of the Company as set
forth in EXHIBIT "A" attached hereto (collectively, the "PLEDGED PROPERTY"):

         The Pledged Property, as set forth in EXHIBIT "A" attached hereto, and
the products thereof and the proceeds of all such items are hereinafter
collectively referred to as the "PLEDGED COLLATERAL."

                  (b) Simultaneously with the execution and delivery of this
Agreement, the Company shall make, execute, acknowledge, file, record and
deliver to the Secured Party any documents reasonably requested by the Secured
Party to perfect its security interest in the Pledged Property. Simultaneously
with the execution and delivery of this Agreement, the Company shall make,
execute, acknowledge and deliver to the Secured Party such documents and
instruments, including, without limitation, financing statements, certificates,
affidavits and forms as may, in the Secured Party's reasonable judgment, be
necessary to effectuate, complete or perfect, or to continue and preserve, the
security interest of the Secured Party in the Pledged Property, and the Secured
Party shall hold such documents and instruments as secured party, subject to the
terms and conditions contained herein.

         Section 2.2. RIGHTS; INTERESTS; ETC.

                  (a) So long as no Event of Default (as hereinafter defined)
shall have occurred and be continuing:

                           (i) the Company shall be entitled to exercise any and
all rights pertaining to the Pledged Property or any part thereof for any
purpose not inconsistent with the terms hereof; and

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                           (ii) the Company shall be entitled to receive and
retain any and all payments paid or made in respect of the Pledged Property.

                  (b) Upon the occurrence and during the continuance of an Event
of Default:

                           (i) All rights of the Company to exercise the rights
which it would otherwise be entitled to exercise pursuant to Section 2.2(a)(i)
hereof and to receive payments which it would otherwise be authorized to receive
and retain pursuant to Section 2.2(a)(ii) hereof shall be suspended, and all
such rights shall thereupon become vested in the Secured Party who shall
thereupon have the sole right to exercise such rights and to receive and hold as
Pledged Collateral such payments; PROVIDED, HOWEVER, that if the Secured Party
shall become entitled and shall elect to exercise its right to realize on the
Pledged Collateral pursuant to Article V hereof, then all cash sums received by
the Secured Party, or held by Company for the benefit of the Secured Party and
paid over pursuant to Section 2.2(b)(ii) hereof, shall be applied against any
outstanding Obligations; and

                           (ii) All interest, dividends, income and other
payments and distributions which are received by the Company contrary to the
provisions of Section 2.2(b)(i) hereof shall be received in trust for the
benefit of the Secured Party, shall be segregated from other property of the
Company and shall be forthwith paid over to the Secured Party; or

                           (iii) The Secured Party in its sole discretion shall
be authorized to sell any or all of the Pledged Property at public or private
sale in order to recoup all of the outstanding principal plus accrued interest
owed pursuant to the Convertible Debenture as described herein

                  (c) Each of the following events shall constitute a default
under this Agreement (each an "EVENT OF DEFAULT"):

                           (i) any default, whether in whole or in part, shall
occur in the payment to the Secured Party of principal, interest or other item
comprising the Obligations as and when due or with respect to any other debt or
obligation of the Company to a party other than the Secured Party;

                           (ii) any default, whether in whole or in part, shall
occur in the due observance or performance of any obligations or other
covenants, terms or provisions to be performed under this Agreement or the
Transaction Documents;

                           (iii) the Company shall: (1) make a general
assignment for the benefit of its creditors; (2) apply for or consent to the
appointment of a receiver, trustee, assignee, custodian, sequestrator,
liquidator or similar official for itself or any of its assets and properties;
(3) commence a voluntary case for relief as a debtor under the United States
Bankruptcy Code; (4) file with or otherwise submit to any governmental authority
any petition, answer or other document seeking: (A) reorganization, (B) an
arrangement with creditors or (C) to take advantage of any other present or
future applicable law respecting bankruptcy, reorganization, insolvency,
readjustment of debts, relief of debtors, dissolution or liquidation; (5) file
or otherwise submit any answer or other document admitting or failing to contest
the material allegations of a petition or other document filed or otherwise
submitted against it in any

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proceeding under any such applicable law, or (6) be adjudicated a bankrupt or
insolvent by a court of competent jurisdiction; or

                           (iv) any case, proceeding or other action shall be
commenced against the Company for the purpose of effecting, or an order,
judgment or decree shall be entered by any court of competent jurisdiction
approving (in whole or in part) anything specified in Section 2.2(c)(iii)
hereof, or any receiver, trustee, assignee, custodian, sequestrator, liquidator
or other official shall be appointed with respect to the Company, or shall be
appointed to take or shall otherwise acquire possession or control of all or a
substantial part of the assets and properties of the Company, and any of the
foregoing shall continue unstayed and in effect for any period of thirty (30)
days.

         Section 2.3 TERMINATION OF SECURITY INTEREST.

                  (a) Notwithstanding any provision to the contrary contained
herein, the rights of Secured Party under this Agreement, including but not
limited to, Secured Party's security interest in the Pledged Property and the
Pledged Collateral, shall automatically terminate upon the occurrence of an
Expiration Event.

                  (b) Upon the occurrence of an Expiration Event, the Secured
Party shall make, execute, acknowledge, file, record and deliver to the Company
any documents reasonably requested by the Company to terminate the Secured
Party's security interest in the Pledged Property and the Pledged Collateral.
Upon the occurrence of an Expiration Event, the Secured Party shall make,
execute, acknowledge and deliver to the Company such documents and instruments,
including, without limitation, financing statements, certificates, affidavits
and forms as may, in the Company's reasonable judgment, be necessary to
eliminate and terminate, the security interest of the Secured Party in the
Pledged Property and the Pledged Collateral, and the Company is authorized to
file such documents as necessary to terminate Secured Party's security interest
in the Pledged Property and the Pledged Collateral.

                                   ARTICLE 3.

                          ATTORNEY-IN-FACT; PERFORMANCE

         Section 3.1. SECURED PARTY APPOINTED ATTORNEY-IN-FACT.

         Upon the occurrence of an Event of Default, the Company hereby appoints
the Secured Party as its attorney-in-fact, with full authority in the place and
stead of the Company and in the name of the Company or otherwise, from time to
time in the Secured Party's discretion to take any action and to execute any
instrument which the Secured Party may reasonably deem necessary to accomplish
the purposes of this Agreement, including, without limitation, to receive and
collect all instruments made payable to the Company representing any payments in
respect of the Pledged Collateral or any part thereof and to give full discharge
for the same. The Secured Party may demand, collect, receipt for, settle,
compromise, adjust, sue for, foreclose, or realize on the Pledged Property as
and when the Secured Party may determine. To facilitate collection, the Secured
Party may notify account debtors and obligors on any Pledged Property or Pledged
Collateral to make payments directly to the Secured Party.

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         Section 3.2. SECURED PARTY MAY PERFORM.

         If the Company fails to perform any agreement contained herein, the
Secured Party, at its option, may itself perform, or cause performance of, such
agreement, and the expenses of the Secured Party incurred in connection
therewith shall be included in the Obligations secured hereby and payable by the
Company under Section 8.3.

                                   ARTICLE 4.

                         REPRESENTATIONS AND WARRANTIES

         Section 4.1. AUTHORIZATION; ENFORCEABILITY.

         Each of the parties hereto represents and warrants that it has taken
all action necessary to authorize the execution, delivery and performance of
this Agreement and the transactions contemplated hereby; and upon execution and
delivery, this Agreement shall constitute a valid and binding obligation of the
respective party, subject to applicable bankruptcy, insolvency, reorganization,
moratorium and similar laws affecting creditors' rights or by the principles
governing the availability of equitable remedies.

         Section 4.2. OWNERSHIP OF PLEDGED PROPERTY.

         The Company warrants and represents that it is the legal and beneficial
owner of the Pledged Property free and clear of any lien, security interest,
option or other charge or encumbrance except for the security interests
identified on EXHIBIT A hereto and the security interest created by this
Agreement.

                                   ARTICLE 5.

                    DEFAULT; REMEDIES; SUBSTITUTE COLLATERAL

         Section 5.1. DEFAULT AND REMEDIES.

                  (a) If an Event of Default described in Section 2.2(c)(i) and
(ii) occurs, then in each such case the Secured Party may declare the
Obligations to be due and payable immediately, by a notice in writing to the
Company, and upon any such declaration, the Obligations shall become immediately
due and payable. If an Event of Default described in Sections 2.2(c)(iii) or
(iv) occurs and is continuing for the period set forth therein, then the
Obligations shall automatically become immediately due and payable without
declaration or other act on the part of the Secured Party.

                  (b) Upon the occurrence of an Event of Default, the Secured
Party shall,: (i) be entitled to receive all distributions with respect to the
Pledged Collateral, (ii) to cause the Pledged Property to be transferred into
the name of the Secured Party or its nominee, (iii) to dispose of the Pledged
Property, and (iv) to realize upon any and all rights in the Pledged Property
then held by the Secured Party.

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         Section 5.2. METHOD OF REALIZING UPON THE PLEDGED PROPERTY : OTHER
REMEDIES.

         Upon the occurrence of an Event of Default, in addition to any rights
and remedies available at law or in equity, the following provisions shall
govern the Secured Party's right to realize upon the Pledged Property:

                  (a) Any item of the Pledged Property may be sold for cash or
other value in any number of lots at brokers board, public auction or private
sale and may be sold without demand, advertisement or notice (except that the
Secured Party shall give the Company ten (10) days' prior written notice of the
time and place or of the time after which a private sale may be made (the "SALE
NOTICE")), which notice period shall in any event is hereby agreed to be
commercially reasonable. At any sale or sales of the Pledged Property, the
Company may bid for and purchase the whole or any part of the Pledged Property
and, upon compliance with the terms of such sale, may hold, exploit and dispose
of the same without further accountability to the Secured Party. The Company
will execute and deliver, or cause to be executed and delivered, such
instruments, documents, assignments, waivers, certificates, and affidavits and
supply or cause to be supplied such further information and take such further
action as the Secured Party reasonably shall require in connection with any such
sale.

                  (b) Any cash being held by the Secured Party as Pledged
Collateral and all cash proceeds received by the Secured Party in respect of,
sale of, collection from, or other realization upon all or any part of the
Pledged Collateral shall be applied as follows:

                           (i) to the payment of all amounts due the Secured
Party for the expenses reimbursable to it hereunder or owed to it pursuant to
Section 8.3 hereof;

                           (ii) to the payment of the Obligations then due and
unpaid.

                           (iii) the balance, if any, to the person or persons
entitled thereto, including, without limitation, the Company.

                  (c) In addition to all of the rights and remedies which the
Secured Party may have pursuant to this Agreement, the Secured Party shall have
all of the rights and remedies provided by law, including, without limitation,
those under the Uniform Commercial Code.

                  (d)

                           (i) If the Company fails to pay such amounts due upon
the occurrence of an Event of Default which is continuing, then the Secured
Party may institute a judicial proceeding for the collection of the sums so due
and unpaid, may prosecute such proceeding to judgment or final decree and may
enforce the same against the Company and collect the monies adjudged or decreed
to be payable in the manner provided by law out of the property of Company,
wherever situated.

                           (ii) The Company agrees that it shall be liable for
any reasonable fees, expenses and costs incurred by the Secured Party in
connection with enforcement, collection and preservation of the Transaction
Documents, including, without limitation, reasonable legal fees

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and expenses, and such amounts shall be deemed included as Obligations secured
hereby and payable as set forth in Section 8.3 hereof.

         Section 5.3. PROOFS OF CLAIM.

         In case of the pendency of any receivership, insolvency, liquidation,
bankruptcy, reorganization, arrangement, adjustment, composition or other
judicial proceeding relating to the Company or the property of the Company or of
such other obligor or its creditors, the Secured Party (irrespective of whether
the Obligations shall then be due and payable as therein expressed or by
declaration or otherwise and irrespective of whether the Secured Party shall
have made any demand on the Company for the payment of the Obligations), subject
to the rights of Previous Security Holders, shall be entitled and empowered, by
intervention in such proceeding or otherwise:

                           (i) to file and prove a claim for the whole amount of
the Obligations and to file such other papers or documents as may be necessary
or advisable in order to have the claims of the Secured Party (including any
claim for the reasonable legal fees and expenses and other expenses paid or
incurred by the Secured Party permitted hereunder and of the Secured Party
allowed in such judicial proceeding), and

                           (ii) to collect and receive any monies or other
property payable or deliverable on any such claims and to distribute the same;
and any custodian, receiver, assignee, trustee, liquidator, sequestrator or
other similar official in any such judicial proceeding is hereby authorized by
the Secured Party to make such payments to the Secured Party and, in the event
that the Secured Party shall consent to the making of such payments directed to
the Secured Party, to pay to the Secured Party any amounts for expenses due it
hereunder.

         Section 5.4. DUTIES REGARDING PLEDGED COLLATERAL.

         The Secured Party shall have no duty as to the collection or protection
of the Pledged Property or any income thereon or as to the preservation of any
rights pertaining thereto, beyond the safe custody and reasonable care of any of
the Pledged Property actually in the Secured Party's possession.

                                   ARTICLE 6.

                              AFFIRMATIVE COVENANTS

         The Company covenants and agrees that, from the date hereof and until
the Obligations have been fully paid and satisfied, unless the Secured Party
shall consent otherwise in writing (as provided in Section 8.4 hereof):

         Section 6.1. EXISTENCE, PROPERTIES, ETC.

                  (a) The Company shall do, or cause to be done, all things, or
proceed with due diligence with any actions or courses of action, that may be
reasonably necessary (i) to maintain Company's due organization, valid existence
and good standing under the laws of its state of incorporation, and (ii) to
preserve and keep in full force and effect all qualifications, licenses and

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registrations in those jurisdictions in which the failure to do so could have a
Material Adverse Effect (as defined below); and (b) the Company shall not do, or
cause to be done, any act impairing the Company's corporate power or authority
(i) to carry on the Company's business as now conducted, and (ii) to execute or
deliver this Agreement or any other document delivered in connection herewith,
including, without limitation, any UCC-1 Financing Statements required by the
Secured Party (which other loan instruments collectively shall be referred to as
the "LOAN INSTRUMENTS") to which it is or will be a party, or perform any of its
obligations hereunder or thereunder. For purpose of this Agreement, the term
"MATERIAL ADVERSE EFFECT" shall mean any material and adverse affect as
determined by Secured Party in its sole discretion, whether individually or in
the aggregate, upon (a) the Company's assets, business, operations, properties
or condition, financial or otherwise; (b) the Company's to make payment as and
when due of all or any part of the Obligations; or (c) the Pledged Property.

         Section 6.2. FINANCIAL STATEMENTS AND REPORTS.

         The Company shall furnish to the Secured Party such financial data as
the Secured Party may reasonably request. Without limiting the foregoing, the
Company shall furnish to the Secured Party (or cause to be furnished to the
Secured Party) the following:

                  (a) as soon as practicable and in any event within ninety (90)
days after the end of each fiscal year of the Company, the balance sheet of the
Company as of the close of such fiscal year, the statement of earnings and
retained earnings of the Company as of the close of such fiscal year, and
statement of cash flows for the Company for such fiscal year, all in reasonable
detail, prepared in accordance with generally accepted accounting principles
consistently applied, certified by the chief executive and chief financial
officers of the Company as being true and correct and accompanied by a
certificate of the chief executive and chief financial officers of the Company,
stating that the Company has kept, observed, performed and fulfilled each
covenant, term and condition of this Agreement and the other Loan Instruments
during such fiscal year and that no Event of Default hereunder has occurred and
is continuing, or if an Event of Default has occurred and is continuing,
specifying the nature of same, the period of existence of same and the action
the Company proposes to take in connection therewith;

                  (b) within thirty (30) days of the end of each calendar month,
a balance sheet of the Company as of the close of such month, and statement of
earnings and retained earnings of the Company as of the close of such month, all
in reasonable detail, and prepared substantially in accordance with generally
accepted accounting principles consistently applied, certified by the chief
executive and chief financial officers of the Company as being true and correct;
and

                  (c) promptly upon receipt thereof, copies of all accountants'
reports and accompanying financial reports submitted to the Company by
independent accountants in connection with each annual examination of the
Company.

         Section 6.3. ACCOUNTS AND REPORTS.

         The Company shall maintain a standard system of accounting in
accordance with generally accepted accounting principles consistently applied
and provide, at its sole expense, to the Secured Party the following:

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                  (a) as soon as available, a copy of any notice or other
communication alleging any nonpayment or other material breach or default, or
any foreclosure or other action respecting any material portion of its assets
and properties, received respecting any of the indebtedness of the Company in
excess of $50,000 (other than the Obligations), or any demand or other request
for payment under any guaranty, assumption, purchase agreement or similar
agreement or arrangement respecting the indebtedness or obligations of others in
excess of $50,000, including any received from any person acting on behalf of
the Secured Party or beneficiary thereof; and

                  (b) within fifteen (15) days after the making of each
submission or filing, a copy of any report, financial statement, notice or other
document, whether periodic or otherwise, submitted to the shareholders of the
Company, or submitted to or filed by the Company with any governmental authority
involving or affecting (i) the Company that could have a Material Adverse
Effect; (ii) the Obligations; (iii) any part of the Pledged Collateral; or (iv)
any of the transactions contemplated in this Agreement or the Loan Instruments.

         Section 6.4. MAINTENANCE OF BOOKS AND RECORDS; INSPECTION.

         The Company shall maintain its books, accounts and records in
accordance with generally accepted accounting principles consistently applied,
and permit the Secured Party, its officers and employees and any professionals
designated by the Secured Party in writing, at any time to visit and inspect any
of its properties (including but not limited to the collateral security
described in the Loan Instruments), corporate books and financial records, and
to discuss its accounts, affairs and finances with any employee, officer or
director thereof.

         Section 6.5. MAINTENANCE AND INSURANCE.

                  (a) The Company shall maintain or cause to be maintained, at
its own expense, all of its assets and properties in good working order and
condition, making all necessary repairs thereto and renewals and replacements
thereof.

                  (b) The Company shall maintain or cause to be maintained, at
its own expense, insurance in form, substance and amounts (including
deductibles), which the Company deems reasonably necessary to the Company's
business, (i) adequate to insure all assets and properties of the Company, which
assets and properties are of a character usually insured by persons engaged in
the same or similar business against loss or damage resulting from fire or other
risks included in an extended coverage policy; (ii) against public liability and
other tort claims that may be incurred by the Company; (iii) as may be required
by the Loan Instruments or applicable law and (iv) as may be reasonably
requested by Secured Party, all with adequate, financially sound and reputable
insurers.

         Section 6.6. CONTRACTS AND OTHER COLLATERAL.

         The Company shall perform all of its obligations under or with respect
to each instrument, receivable, contract and other intangible included in the
Pledged Property to which the Company is now or hereafter will be party on a
timely basis and in the manner therein required, including, without limitation,
this Agreement.

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         Section 6.7. DEFENSE OF COLLATERAL, ETC.

         The Company shall defend and enforce its right, title and interest in
and to any part of: (a) the Pledged Property; and (b) if not included within the
Pledged Property , those assets and properties whose loss could have a Material
Adverse Effect, the Company shall defend the Secured Party's right, title and
interest in and to each and every part of the Pledged Property, each against all
manner of claims and demands on a timely basis to the full extent permitted by
applicable law.

         Section 6.8. PAYMENT OF DEBTS, TAXES, ETC.

         The Company shall pay, or cause to be paid, all of its indebtedness and
other liabilities and perform, or cause to be performed, all of its obligations
in accordance with the respective terms thereof, and pay and discharge, or cause
to be paid or discharged, all taxes, assessments and other governmental charges
and levies imposed upon it, upon any of its assets and properties on or before
the last day on which the same may be paid without penalty, as well as pay all
other lawful claims (whether for services, labor, materials, supplies or
otherwise) as and when due.

         Section 6.9. TAXES AND ASSESSMENTS; TAX INDEMNITY.

         The Company shall (a) file all tax returns and appropriate schedules
thereto that are required to be filed under applicable law, prior to the date of
delinquency, (b) pay and discharge all taxes, assessments and governmental
charges or levies imposed upon the Company, upon its income and profits or upon
any properties belonging to it, prior to the date on which penalties attach
thereto, and (c) pay all taxes, assessments and governmental charges or levies
that, if unpaid, might become a lien or charge upon any of its properties;
PROVIDED, HOWEVER, that the Company in good faith may contest any such tax,
assessment, governmental charge or levy described in the foregoing clauses (b)
and (c) so long as appropriate reserves are maintained with respect thereto.

         Section 6.10. COMPLIANCE WITH LAW AND OTHER AGREEMENTS.

         The Company shall maintain its business operations and property owned
or used in connection therewith in compliance with (a) all applicable federal,
state and local laws, regulations and ordinances governing such business
operations and the use and ownership of such property, and (b) all agreements,
licenses, franchises, indentures and mortgages to which the Company is a party
or by which the Company or any of its properties is bound. Without limiting the
foregoing, the Company shall pay all of its indebtedness promptly in accordance
with the terms thereof.

         Section 6.11. NOTICE OF DEFAULT.

         The Company shall give written notice to the Secured Party of the
occurrence of any default or Event of Default under this Agreement, the
Transaction Documents or any other Loan Instrument or any other agreement of
Company for the payment of money, promptly upon the occurrence thereof.

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         Section 6.12. NOTICE OF LITIGATION.

         The Company shall give notice, in writing, to the Secured Party of (a)
any actions, suits or proceedings wherein the amount at issue is in excess of
$50,000, instituted by any persons against the Company, or affecting any of the
assets of the Company, and (b) any dispute, not resolved within fifteen (15)
days of the commencement thereof, between the Company on the one hand and any
governmental or regulatory body on the other hand, which might reasonably be
expected to have a Material Adverse Effect on the business operations or
financial condition of the Company.

                                   ARTICLE 7.

                               NEGATIVE COVENANTS

         The Company agrees to abide by the covenants set forth in the
Securities Purchase Agreement. The covenants contained in the Securities
Purchase Agreement, and any of the Transaction Documents, shall remain in full
force and effect pursuant to their terms, notwithstanding the termination of
this Agreement.

                                   ARTICLE 8.

                                  MISCELLANEOUS

         Section 8.1. NOTICES.

         All notices or other communications required or permitted to be given
pursuant to this Agreement shall be in writing and shall be considered as duly
given on: (a) the date of delivery, if delivered in person, by nationally
recognized overnight delivery service or (b) five (5) days after mailing if
mailed from within the continental United States by certified mail, return
receipt requested to the party entitled to receive the same:

          If to the Secured Party:      Cornell Capital Partners, LP
                                        101 Hudson Street-Suite 3606
                                        Jersey City, New Jersey 07302
                                        Attention: Mark Angelo
                                                   Portfolio Manager
                                        Telephone: (201) 986-8300
                                        Facsimile: (201) 985-8266

          With a copy to:               Butler Gonzalez LLP
                                        1000 Stuyvesant Avenue - Suite 6
                                        Union, New Jersey  07083
                                        Attention: David Gonzalez, Esq.
                                        Telephone: (908) 810-8588
                                        Facsimile: (908) 810-0973

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          And if to the Company:        Advanced Viral Research Corp.
                                        200 Corporate Boulevard South
                                        Yonkers, NY 10701
                                        Attention: Alan Gallantar,
                                                   Chief Financial Officer
                                        Telephone: (914) 376-7383
                                        Facsimile: (914) 376-7638

          With a copy to:               Kirkpatrick & Lockhart LLP
                                        201 South Biscayne Boulevard-Suite 2000
                                        Miami, Florida  33131-2399
                                        Attention: Clayton E. Parker, Esq.
                                        Telephone: (305) 539-3300
                                        Facsimile: (305) 358-7095

         Any party may change its address by giving notice to the other party
stating its new address. Commencing on the tenth (10th) day after the giving of
such notice, such newly designated address shall be such party's address for the
purpose of all notices or other communications required or permitted to be given
pursuant to this Agreement.

         Section 8.2. SEVERABILITY.

         If any provision of this Agreement shall be held invalid or
unenforceable, such invalidity or unenforceability shall attach only to such
provision and shall not in any manner affect or render invalid or unenforceable
any other severable provision of this Agreement, and this Agreement shall be
carried out as if any such invalid or unenforceable provision were not contained
herein.

         Section 8.3. EXPENSES.

         In the event of an Event of Default, the Company will pay to the
Secured Party the amount of any and all reasonable expenses, including the
reasonable fees and expenses of its counsel, which the Secured Party may incur
in connection with: (i) the custody or preservation of, or the sale, collection
from, or other realization upon, any of the Pledged Property; (ii) the exercise
or enforcement of any of the rights of the Secured Party hereunder or (iii) the
failure by the Company to perform or observe any of the provisions hereof.

         Section 8.4. WAIVERS, AMENDMENTS, ETC.

         The Secured Party's delay or failure at any time or times hereafter to
require strict performance by Company of any undertakings, agreements or
covenants shall not waiver, affect, or diminish any right of the Secured Party
under this Agreement to demand strict compliance and performance herewith. Any
waiver by the Secured Party of any Event of Default shall not waive or affect
any other Event of Default, whether such Event of Default is prior or subsequent
thereto and whether of the same or a different type. None of the undertakings,
agreements and covenants of the Company contained in this Agreement, and no
Event of Default, shall be deemed to have been waived by the Secured Party, nor
may this Agreement be amended, changed or modified, unless such waiver,
amendment, change or modification is evidenced by an

                                       12
<PAGE>

instrument in writing specifying such waiver, amendment, change or modification
and signed by the Secured Party.

         Section 8.5. CONTINUING SECURITY INTEREST.

         This Agreement shall create a continuing security interest in the
Pledged Property and shall: (i) remain in full force and effect until the
occurrence of an Expiration Event; and (ii) be binding upon the Company and its
successors and heirs and (iii) inure to the benefit of the Secured Party and its
successors and assigns. Upon the occurrence of an Expiration Event, the Company
shall be entitled to the return, at its expense, of such of the Pledged Property
as shall not have been sold in accordance with Section 5.2 hereof or otherwise
applied pursuant to the terms hereof.

         Section 8.6. INDEPENDENT REPRESENTATION.

         Each party hereto acknowledges and agrees that it has received or has
had the opportunity to receive independent legal counsel of its own choice and
that it has been sufficiently apprised of its rights and responsibilities with
regard to the substance of this Agreement.

         Section 8.7. APPLICABLE LAW: JURISDICTION.

         This Agreement shall be governed by and interpreted in accordance with
the laws of the State of Delaware without regard to the principles of conflict
of laws. The parties further agree that any action between them shall be heard
in Hudson County, New Jersey, and expressly consent to the jurisdiction and
venue of the Superior Court of New Jersey, sitting in Hudson County and the
United States District Court for the District of New Jersey sitting in Newark,
New Jersey for the adjudication of any civil action asserted pursuant to this
Paragraph.

         Section 8.8. WAIVER OF JURY TRIAL.

         AS A FURTHER INDUCEMENT FOR THE SECURED PARTY TO ENTER INTO THIS
AGREEMENT AND TO MAKE THE FINANCIAL ACCOMMODATIONS TO THE COMPANY, THE COMPANY
HEREBY WAIVES ANY RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING RELATED IN ANY
WAY TO THIS AGREEMENT AND/OR ANY AND ALL OTHER DOCUMENTS RELATED TO THIS
TRANSACTION.

         Section 8.9. ENTIRE AGREEMENT.

         This Agreement constitutes the entire agreement among the parties and
supersedes any prior agreement or understanding among them with respect to the
subject matter hereof.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

                                       13
<PAGE>

         IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the date first above written.

                                       COMPANY:
                                       ADVANCED VIRAL RESEARCH CORP.

                                       By: /s/ SHALOM Z. HIRSCHMAN
                                           -------------------------------------
                                       Name:  Shalom Z. Hirschman
                                       Title:  Chief Executive Officer

                                       SECURED PARTY:
                                       CORNELL CAPITAL PARTNERS, LP

                                       BY: YORKVILLE ADVISORS, LLC
                                       ITS: GENERAL PARTNER

                                       By: /s/ MARK ANGELO
                                           -------------------------------------
                                       Name:  Mark Angelo
                                       Title: Portfolio Manager

                                       14
<PAGE>

                                    EXHIBIT A
                         DEFINITION OF PLEDGED PROPERTY

         For the purpose of securing prompt and complete payment and performance
by the Company of all of the Obligations, the Company unconditionally and
irrevocably hereby grants to the Secured Party a continuing security interest in
and to, and lien upon, the following Pledged Property of the Company:

                  (a) all goods of the Company, including, without limitation,
machinery, equipment, furniture, furnishings, fixtures, signs, lights, tools,
parts, supplies and motor vehicles of every kind and description, now or
hereafter owned by the Company or in which the Company may have or may hereafter
acquire any interest, and all replacements, additions, accessions, substitutions
and proceeds thereof, arising from the sale or disposition thereof, and where
applicable, the proceeds of insurance and of any tort claims involving any of
the foregoing;

                  (b) all inventory of the Company, including, but not limited
to, all goods, wares, merchandise, parts, supplies, finished products, other
tangible personal property, including such inventory as is temporarily out of
Company's custody or possession and including any returns upon any accounts or
other proceeds, including insurance proceeds, resulting from the sale or
disposition of any of the foregoing;

                  (c) all contract rights and general intangibles of the
Company, including, without limitation, goodwill, trademarks, trade styles,
trade names, leasehold interests, partnership or joint venture interests,
patents and patent applications, including but not limited to those relating to
the composition and uses of Product R, copyrights, deposit accounts whether now
owned or hereafter created;

                  (d) all documents, warehouse receipts, instruments and chattel
paper of the Company whether now owned or hereafter created;

                  (e) all accounts and other receivables, instruments or other
forms of obligations and rights to payment of the Company (herein collectively
referred to as "ACCOUNTS"), together with the proceeds thereof, all goods
represented by such Accounts and all such goods that may be returned by the
Company's customers, and all proceeds of any insurance thereon, and all
guarantees, securities and liens which the Company may hold for the payment of
any such Accounts including, without limitation, all rights of stoppage in
transit, replevin and reclamation and as an unpaid vendor and/or lienor, all of
which the Company represents and warrants will be bona fide and existing
obligations of its respective customers, arising out of the sale of goods by the
Company in the ordinary course of business;

                  (f) to the extent assignable, all of the Company's rights
under all present and future authorizations, permits, licenses and franchises
issued or granted in connection with the operations of any of its facilities;

                  (g) all products and proceeds (including, without limitation,
insurance proceeds) from the above-described Pledged Property.

                                      A-1<PAGE>
                                                                   Exhibit 10.82

                          FIRST SUPPLEMENTARY AGREEMENT

                Made and entered in to this 8th day of July, 2002
                                 By and between

                  YEDA RESEARCH AND DEVELOPMENT COMPANY LIMITED

               a company duly registered under the laws of Israel
                      of P.O. Box 95, Rehovot 76100, Israel
                              (hereinafter: "YEDA")

                                       and

                          ADVANCED VIRAL RESEARCH CORP

            a company duly registered under the laws of the state of
               New York, of 200 Corporate Boulevard South Yonkers,
                                  NY10701, USA
                           (hereinafter "THE COMPANY")

WHEREAS  the parties have entered into an Agreement dated January 29, 2001 (the
         "AGREEMENT"); and

WHEREAS  The parties wish to extend the Study Period for another 12 (twelve
         months) commencing at the date of signature hereof (the "SECOND YEAR")

WHEREAS  the parties wish to set up a Research Budget for the Second Year.

THEREFORE THE PARTIES DO HEREBY AGREE AS FOLLOWS:

1.       Terms and phrases included in this First Supplementary Agreement
         ("Supplementary Agreement") which are defined in the Agreement shall
         have the same meaning attributed to them in the Agreement unless
         otherwise defined in this Supplementary Agreement or unless the context
         otherwise requires.

<PAGE>

2.       This Supplementary Agreement and the Agreement shall be read as one and
         shall represent the complete current understanding between the parties
         with respect to the Second Year of the Study. Subject to the
         modifications contained herein, the provisions of the Agreement shall
         remain unaltered and in full force and effect.

3.       All appendixes attached hereto shall form an integral part of this
         Agreement

4.       The Study Plan attached to the Agreement as Appendix A shall be
         supplemented by the Research Program attached hereto marked Appendix
         Al.                                                                  AL

5.       The Study Period is hereby extended for a Second Year.

6.       The Budget for the Second Year of the Study Period as stated in
         Appendix S of the Agreement be supplemented by Appendix B1 to this
         Supplementary Agreement, and shall total US$ 138,000 (One hundred and
         Thirty Eight Thousand United States Dollars).                        BI

7.       The Company agrees and undertakes to pay Yeda US$ 138,000 (One Hundred
         and Thirty Eight Thousand US Dollars) as follows:

(a)      US$ 40,000 (Forty Thousand US Dollars) upon execution of this
         Agreement; and

(b)      US$ 40,000 (Forty Thousand US Dollars) upon expiry of 4 (four) months
         of the extended Study Period; and

(c)      US$ 40,000 (Forty Thousand US Do upon the expiry of 8 (eight) months of
         the extended Study Period; and

(d)      US$ 18,000 (Eighteen Thousand US Dollars) within 7 (seven) days after
         the Company accepts that the final report required in sub-clause 4.1 to
         the Agreement.

8.       Late payments shall bear interest from due date until date of payment
         until the date of actual payment, at the rate of 3% (three percent) per
         annum in excess of the average LIBOR rate for US Dollar deposits for a
         period of 3 (three) months prevailing from time to time during tie
         period of arrears.

                                       2
<PAGE>

IN WITNESS WHEREOF THE PARTIES HERETO HAVE SET THEIR SIGNATURES.

for  YEDA RESEARCH AND                 for ADVANCED VIRAL RESEARCH CORP
     DEVELOPMENT COMPANY LTD.

By: /s/ DR. ISAAC SHARIV   /s/ PROF. HAIM GARTY  By: /s/ SHALOM Z HIRSCHMAN, MD
    --------------------   --------------------      --------------------------
    Title: C.E.O.                CHAIRMAN            Title: PRESIDENT AND C.E.O.

                                       3

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