Document:

Credit agreement dated February 23, 2005

 Exhibit 10.1 
 Execution Copy 
  

  
 CREDIT AGREEMENT 
  
 Dated as of February 23, 2005 
  
 among 
  
 Sigma-Aldrich Corporation, 
  
 The Lenders Party Hereto, 
  
 Wells
Fargo Bank, National Association, 
 as Administrative Agent and 
 Letter of Credit Issuer 
  
 Wells
Fargo Bank, National Association 
 and 
 Wachovia Capital Markets, LLC 
 as Joint Lead Arrangers 
  
 Wachovia Bank, N.A., 
 as Syndication Agent 
  
 U.S. Bank N.A. 
 The Bank of Tokyo-Mitsubishi, Ltd., Chicago Branch 
 and 
 ABN AMRO Bank N.V. 
 as Co-Documentation Agents 
  

					
	 ARTICLE I DEFINITIONS
	  	1
			
	 Section 1.01
	  	 Definitions
	  	1
	 Section 1.02
	  	 Accounting Terms and Determinations
	  	12
	 Section 1.03
	  	 Types of Borrowings
	  	13
		
	 ARTICLE II THE CREDITS
	  	13
			
	 Section 2.01
	  	 Commitments to Lend.
	  	13
	 Section 2.02
	  	 Notice of Borrowings.
	  	13
	 Section 2.03
	  	 Notice to Lenders; Funding of Loans.
	  	15
	 Section 2.04
	  	 Notes.
	  	15
	 Section 2.05
	  	 Maturity of Loans
	  	16
	 Section 2.06
	  	 Interest Rates.
	  	16
	 Section 2.07
	  	 Loan Fees.
	  	16
	 Section 2.08
	  	 Optional Termination, Reduction or Increase of Commitments.
	  	17
	 Section 2.09
	  	 Mandatory Termination of Commitments
	  	20
	 Section 2.10
	  	 Prepayments.
	  	20
	 Section 2.11
	  	 General Provisions as to Payments.
	  	20
	 Section 2.12
	  	 Funding Losses
	  	21
	 Section 2.13
	  	 Computation of Interest and Fees
	  	21
	 Section 2.14
	  	 Withholding Tax Exemption.
	  	21
	 Section 2.15
	  	 Letters of Credit.
	  	22
		
	 ARTICLE III CONDITIONS
	  	26
			
	 Section 3.01
	  	 Effectiveness
	  	26
	 Section 3.02
	  	 Borrowings
	  	27
		
	 ARTICLE IV REPRESENTATIONS AND WARRANTIES
	  	28
			
	 Section 4.01
	  	 Corporate Existence and Power
	  	28
	 Section 4.02
	  	 Corporate and Governmental Authorization; No Contravention
	  	28
	 Section 4.03
	  	 Binding Effect
	  	28
	 Section 4.04
	  	 Financial Information.
	  	28
	 Section 4.05
	  	 Litigation
	  	29
	 Section 4.06
	  	 Compliance with ERISA
	  	29
	 Section 4.07
	  	 Environmental Matters
	  	29
	 Section 4.08
	  	 Taxes
	  	29
	 Section 4.09
	  	 Subsidiaries
	  	30
	 Section 4.10
	  	 Full Disclosure
	  	30
	 Section 4.11
	  	 Regulated Entities
	  	30
	 Section 4.12
	  	 Compliance With Laws
	  	30
	 Section 4.13
	  	 Default or Event of Default
	  	30
	 Section 4.14
	  	 Liens
	  	30
	 Section 4.15
	  	 Material Agreements
	  	30

  

 i 

					
	 ARTICLE V COVENANTS
	  	31
			
	 Section 5.01
	  	 Information
	  	31
	 Section 5.02
	  	 Maintenance of Property; Insurances.
	  	33
	 Section 5.03
	  	 Conduct of Business and Maintenance of Existence
	  	33
	 Section 5.04
	  	 Compliance with Laws
	  	33
	 Section 5.05
	  	 Capitalization Ratio
	  	33
	 Section 5.06
	  	 Consolidated Net Worth
	  	33
	 Section 5.07
	  	 Negative Pledge
	  	34
	 Section 5.08
	  	 Consolidations, Mergers and Sales of Assets
	  	34
	 Section 5.09
	  	 Transactions with Affiliates
	  	35
	 Section 5.10
	  	 Use of Proceeds
	  	35
	 Section 5.11
	  	 Limitation on Debt
	  	35
	 Section 5.12
	  	 Limitation on Certain Covenants and Restrictions
	  	35
	 Section 5.13
	  	 Taxes
	  	36
		
	 ARTICLE VI DEFAULTS
	  	36
			
	 Section 6.01
	  	 Events of Default
	  	36
	 Section 6.02
	  	 Notice of Default
	  	38
		
	 ARTICLE VII THE ADMINISTRATIVE AGENT AND LETTER OF CREDIT ISSUER
	  	38
			
	 Section 7.01
	  	 Appointment
	  	38
	 Section 7.02
	  	 Nature of Duties
	  	38
	 Section 7.03
	  	 Exculpation Rights, Etc
	  	39
	 Section 7.04
	  	 Reliance
	  	39
	 Section 7.05
	  	 Indemnification
	  	40
	 Section 7.06
	  	 Administrative Agent In Its Individual Capacity
	  	40
	 Section 7.07
	  	 Notice of Default
	  	40
	 Section 7.08
	  	 Holders of Obligations
	  	40
	 Section 7.09
	  	 Resignation by the Administrative Agent.
	  	41
	 Section 7.10
	  	 Application of Article VII to Letter of Credit Issuer
	  	41
	 Section 7.11
	  	 Co-Agents
	  	41
		
	 ARTICLE VIII CHANGE IN CIRCUMSTANCES
	  	41
			
	 Section 8.01
	  	 Basis for Determining Interest Rate Inadequate or Unfair
	  	41
	 Section 8.02
	  	 Illegality
	  	42
	 Section 8.03
	  	 Increased Cost and Reduced Return.
	  	42
	 Section 8.04
	  	 Base Rate Loans Substituted for Affected LIBOR Loans
	  	44
		
	 ARTICLE IX MISCELLANEOUS
	  	44
			
	 Section 9.01
	  	 Notices
	  	44
	 Section 9.02
	  	 No Waivers
	  	44
	 Section 9.03
	  	 Expenses; Documentary Taxes; Indemnification.
	  	44
	 Section 9.04
	  	 Sharing of Set-Offs
	  	45

  

 ii 

					
	 Section 9.05
	  	 Amendments and Waivers
	  	45
	 Section 9.06
	  	 Successors and Assigns.
	  	46
	 Section 9.07
	  	 Collateral
	  	48
	 Section 9.08
	  	 GOVERNING LAW; SUBMISSION TO JURISDICTION
	  	48
	 Section 9.09
	  	 Counterparts; Integration
	  	49
	 Section 9.10
	  	 Confidentiality
	  	49
	 Section 9.11
	  	 Patriot Act Notification
	  	49
	 Section 9.12
	  	 WAIVER OF JURY TRIAL
	  	50

  
  

 iii 

 Pricing Schedule – Revolving Facility 
 Pricing Schedule – Term Facility 
 Schedule 1.01 - Commitments 
 Schedule 4.05 - Litigation 
 Schedule 4.06 - ERISA 
 Schedule 4.09 - Subsidiaries 
 Schedule 5.07 - Existing Liens 
 Schedule 9.01 - Notice Information 
  
 Exhibit A-1 - Revolving Note 
 Exhibit A-2 - Term Note 
 Exhibit B - Opinion of Borrower’s Special Counsel 
 Exhibit C -
Assignment and Assumption Agreement 
 Exhibit D - Compliance Certificate 
 Exhibit E - Form of Notice of Borrowing 
 Exhibit F - Form of Notice of Conversion/Continuation 
 Exhibit G - Form of Lender Assumption Agreement 
  

 iv 

 CREDIT AGREEMENT 
  
 THIS CREDIT AGREEMENT, dated as of February 23, 2005, is by and among SIGMA-ALDRICH CORPORATION, a Delaware corporation, the
Lenders from time to time party hereto, WELLS FARGO BANK, NATIONAL ASSOCIATION, as Administrative Agent and Letter of Credit Issuer, WELLS FARGO BANK, NATIONAL ASSOCIATION and WACHOVIA CAPITAL MARKETS, LLC as Joint Lead Arrangers for the Lenders,
WACHOVIA BANK, N.A., as Syndication Agent, and ABN AMRO BANK N.V., THE BANK OF TOKYO-MITSUBISHI, LTD., CHICAGO BRANCH AND U.S. BANK N.A., as Co-Documentation Agents. 
  
 W I T N E S S E T H: 
  
 WHEREAS, the Borrower has requested that the Lenders provide a credit
facility to the Borrower in an aggregate principal amount not to exceed $300,000,000 at any time outstanding, consisting of (i) a revolving credit facility to the Borrower in an aggregate principal amount not to exceed $150,000,000 at any time
outstanding (except as provided in Section 2.08(c)); and (ii) a term loan facility to the Borrower in an aggregate principal amount not to exceed $150,000,000 at any time outstanding; 
  
 WHEREAS, the proceeds of (i) the revolving credit facility will be used by
the Borrower for general corporate purposes, including, without limitation, to pay commercial paper obligations of the Borrower and issue Letters of Credit, and (ii) the term loan facility will be used by the Borrower to fund a portion of the
purchase price for the acquisition of JRH Biosciences, a division of CSL Limited, a company incorporated in England and Wales (“JRH/UK”), JRH Biosciences PTY Ltd., a company incorporated in Australia (“JRH/Australia”), CSL US
Inc., a Delaware corporation (“JRH/US”, each a direct or indirect susidiary of CSL Limited, a company incorporated in Australia and collectively “JRH Biosciences”); and 
  
 WHEREAS, the Lenders are willing to extend Commitments to make Loans and
issue Letters of Credit to the Borrower hereunder, in each case, for the respective purposes provided herein and only on the terms and subject to the conditions hereinafter set forth. 
  
 NOW, THEREFORE, in consideration of the premises and of the mutual covenants herein contained, the parties hereto agree as
follows: 
  
 ARTICLE I 
  
 DEFINITIONS 
  
 Section 1.01 Definitions. The following terms, as used herein, have the following meanings: 
  
 “Administrative Agent” means Wells Fargo in its capacity as
Administrative Agent for the Lenders hereunder, and its successors in such capacity. 
  
 “Administrative Agent-Related Persons” means the Administrative Agent (including any successor Administrative Agent), together with its Affiliates, and the officers, directors, employees, agents and
attorneys-in-fact of such Persons and Affiliates. 

 “Administrative Questionnaire” means, with respect to each Lender, an administrative
questionnaire in the form prepared by the Administrative Agent and submitted to the Administrative Agent duly completed by such Lender. 
  
 “Affiliate” means, with respect to any Person, any other Person that directly, or indirectly through one or more intermediaries,
controls, is controlled by or is under common control with such Person. As used herein, the term “control” means possession, directly or indirectly, of the power to direct or cause the direction of the management or policies of a
Person, whether through the ownership of voting securities, by contract or otherwise; provided that any Person which does not own, directly or indirectly, more than 15% of any class of voting securities (or other ownership interests) of such
other Person shall not be deemed to “control” such Person. 
  
 “Agreement” means this Credit Agreement, as amended, supplemented or otherwise modified from time to time. 
  
 “Applicable Lending Office” means, with respect to any Lender, (i) in the case of its Base Rate Loans, its Base Rate Lending Office and
(ii) in the case of its LIBOR Loans, its LIBOR Lending office. 
  
 “Assignee” has the meaning set forth in Section 9.06(c). 
  
 “Assignment and Assumption Agreement” has the meaning set forth in Section 9.06(c). 
  
 “Authorized Officer” means any of the Chairman, Chief Executive Officer, President, Chief Operating Officer, Chief Financial Officer,
Treasurer, Corporate Controller or any Vice President and Chief Administrative Officer of the Borrower or any other officer designated by the Borrower in writing to the Administrative Agent, in each case acting singly. 
  
 “Bankruptcy Code” means chapter 11 of title 11 of the United
States Code, 11 U.S.C. §101 et. seq. 
  
 “Base
Rate” means, for any day, a rate of interest per annum equal to the higher of (i) the Prime Rate for such day, and (ii) the sum of the Federal Funds Effective Rate for such day plus 1/2% per annum. 
  
 “Base Rate Lending Office” means, as to each Lender, its
office located at its address set forth in its Administrative Questionnaire (or identified in its Administrative Questionnaire as its Base Rate Lending Office) or such other office as such Lender may hereafter designate as its Base Rate Lending
Office by notice to the Borrower and the Administrative Agent. 
  
 “Base Rate Loan” means a Loan bearing interest at the Base Rate. 
  
 “Benefit Arrangement” means at any time an employee benefit plan within the meaning of Section 3(3) of ERISA which is not a Plan or a Multiemployer Plan and which is maintained or otherwise
contributed to by any member of the ERISA Group. 
  

 2 

 “Board of Directors” means the board of directors of the Borrower as it may be
constituted at any relevant time. 
  
 “Borrower”
means Sigma-Aldrich Corporation, a Delaware corporation, and its successors. 
  
 “Borrowing” has the meaning set forth in Section 1.03. 
  
 “Business Day” means (i) with respect to any borrowing, payment or rate selection of LIBOR Loans a day (other than a Saturday on Sunday)
on which banks generally are open in Chicago and San Francisco for the conduct of substantially all of their commercial lending activities and on which dealings in United States dollars are carried on in the London interbank market and (ii) for all
other purposes, a day (other than a Saturday or Sunday) on which banks generally are open in Chicago and San Francisco for the conduct of substantially all of their commercial lending activities. 
  
 “Capital Lease Obligation” of any Person means the
obligation to pay rent or other payment amounts under a lease of (or other indebtedness arrangements conveying the right to use) real or personal property of such Person which is required to be classified and accounted for as an asset and a
liability on the face of a balance sheet of such Person in accordance with generally accepted accounting principles. 
  
 “Capitalization Ratio” means at any date the ratio of (x) Consolidated Debt, to (y) the sum of Consolidated Debt plus Consolidated Net
Worth. 
  
 “Commitment” means, with respect to
any Lender, the aggregate amount of its Total Revolving Commitments and Term Commitments. 
  
 “Commitment Percentage” means, with respect to each Lender, the percentage equal to a fraction the numerator of which is the amount of such Lender’s Commitment and the denominator of which is the
aggregate amount of the Commitments of the Lenders. 
  
 “Compliance Certificate” means a certificate delivered in accordance with Section 5.01(c). 
  
 “Consolidated Debt” means at any date the Debt of the Borrower and its Subsidiaries, determined on a consolidated basis as of such date.

  
 “Consolidated Net Worth” means, at any time:
(a) the total assets of the Borrower and its Subsidiaries which would be shown as assets on a consolidated balance sheet of the Borrower and its Subsidiaries as of such time prepared in accordance with generally accepted accounting principles, after
eliminating all amounts properly attributable to minority interests, if any, in the stock and surplus of Subsidiaries; minus (b) the total liabilities of the Borrower and its 

  

 3 

 
Subsidiaries which would be shown as liabilities on a consolidated balance sheet of the Borrower and its Subsidiaries as of such time prepared in accordance
with generally accepted accounting principles; minus (c) any consolidated balance sheet foreign currency translation adjustment. 
  
 “Debt” of any Person means at any date, without duplication, (i) all obligations of such Person for borrowed money, (ii) all obligations
of such Person evidenced by bonds, debentures, notes or other similar instruments, (iii) all fixed or contingent reimbursement obligations of such Person with respect to letters of credit, (iv) all obligations of such Person to pay the deferred
purchase price of property or services (other than trade accounts payable, deferred compensation items, and like expense accruals arising in the ordinary course of business), except, in the case of property, to the extent that the rights and
remedies of the obligor with respect to such obligations are limited to repossession or sale of such property, (v) all Capital Lease Obligations of such Person, (vi) all obligations of such Person for Swaps, (vii) all Debt of others secured by a
Lien on any asset of such Person, whether or not such Debt is assumed by such Person, (viii) the aggregate amount of uncollected accounts receivable of such Person subject at such time to a sale of receivables (or similar transaction) regardless of
whether such transaction is effected without recourse to such Person or in a manner that would not be reflected on the balance sheet of such Person in accordance with generally accepted accounting principles, (ix) all Synthetic Lease Obligations,
and (x) all Debt of others Guaranteed by such Person. The amount of any Debt secured by a Lien pursuant to clause (vii) above shall be an amount equal to the lesser of (x) the aggregate outstanding amount of Debt secured by such Lien and (y) the
greater of the aggregate book value and the aggregate fair market value of the assets subject to such Lien. 
  
 “Default” means any condition or event which constitutes an Event of Default or which with the giving of notice or lapse of time, or
both, would, unless cured or waived, become an Event of Default. 
  
 “Effective Date” means the date this Agreement becomes effective in accordance with Section 3.01. 
  
 “Environmental Laws” means any and all federal, state, local and foreign statutes, laws, regulations, ordinances, rules or other
governmental restrictions relating to the environment or to emissions, discharges or releases of pollutants, contaminants, petroleum or petroleum products, chemicals or toxic or hazardous substances or wastes into the environment including, without
limitation, ambient air, surface water, ground water, or land, or otherwise relating to the manufacture, processing, distribution, use, treatment, storage, disposal, transport or handling of pollutants, contaminants, petroleum or petroleum products,
chemicals or toxic or hazardous substances or wastes or the clean-up or other remediation thereof and any and all judgments, orders, decrees, permits, grants, franchises, licenses or agreements relating to the foregoing to which the Borrower or any
Subsidiary is a party or which is otherwise applicable to the Borrower or any Subsidiary. 
  
 “Eligible Lender” means a financial institution mutually agreed upon by both Administrative Agent and Borrower, such consent shall not be unreasonably withheld. 
  
 “ERISA” means the Employee Retirement Income Security Act of
1974, as amended, or any successor statute. 
  

 4 

 “ERISA Group” means the Borrower and all members of a controlled group of corporations
and all trades or businesses (whether or not incorporated) under common control which, together with the Borrower, are treated, on or after the Effective Date, as a single employer under Section 414 of the Internal Revenue Code. 
  
 “Event of Default” has the meaning set forth in Section
6.01. 
  
 “Existing 364-Day Agreement” means
that certain Credit Agreement (364-Day Facility) dated as December 12, 2001 among the Borrower, the Lenders party thereto, Wells Fargo Bank, National Association, as Administrative Agent and as sole Lead Arranger, Wachovia Bank, N.A. and U.S. Bank
N.A., as Co-Syndication Agents, and ABN AMRO Bank N.V. and The Bank of Tokyo-Mitsubishi, Ltd., Chicago Branch, as Co-Documentation Agents, as from time to time amended, restated or modified. 
  
 “Facility Fee Rate” has the meaning set forth in Section
2.07(a). 
  
 “Federal Funds Effective
Rate” means, for any day, an interest rate per annum equal to the weighted average of the rates on overnight Federal funds transactions with members of the Federal Reserve System arranged by Federal funds brokers on such day, as
published for such day (or, if such day is not a Business Day, for the immediately preceding Business Day) by the Federal Reserve Bank of New York, or, if such rate is not so published for any day which is a Business Day, the average of the
quotations at approximately 9:00 a.m. (Chicago time) on such day on such transactions received by the Administrative Agent from three Federal funds brokers of recognized standing selected by the Administrative Agent in its sole discretion.

  
 “Fee Letter” means either of the letter
agreements, relating to certain agency and arrangement fees, between the Borrower and (i) Wells Fargo, in its capacity as Administrative Agent and Joint Lead Arranger, or (ii) Wachovia Bank, N.A. in its capacity as Joint Lead Arranger, as amended,
supplemented or otherwise modified from time to time. 
  
 “Fiscal Quarter” means a fiscal quarter of the Borrower. 
  
 “Fiscal Year” means a fiscal year of the Borrower. 
  
 “5-Year Agreement” means that certain Credit Agreement (5-Year Facility) dated as of December 12, 2001 among the Borrower, the Lenders
party thereto, Wells Fargo Bank, National Association, as Administrative Agent and as sole Lead Arranger, Wachovia Bank, N.A. and U.S. Bank N.A., as Co-Syndication Agents, and ABN AMRO Bank N.V. and The Bank of Tokyo-Mitsubishi, Ltd., Chicago
Branch, as Co-Documentation Agents, as from time to time amended, restated or modified. 
  
 “Governmental Authority” shall mean any nation or government where the Borrower or its Subsidiaries do business, any state or other political subdivision thereof, any central bank (or similar monetary
or regulatory authority) thereof, any entity exercising executive, legislative, 

  

 5 

 
judicial, regulatory or administrative functions of or pertaining to government, and any corporation or other entity owned or controlled, through stock or
capital ownership or otherwise, by any of the foregoing. 
  
 “Guarantee” by any Person means any obligation, contingent or otherwise, of such Person directly or indirectly guaranteeing any Debt of any other Person and, without limiting the generality of the foregoing, any obligation,
direct or indirect, contingent or otherwise, of such Person (i) to purchase or pay (or advance or supply funds for the purchase or payment of) such Debt or other obligation (whether arising by virtue of partnership arrangements, by agreement to
keep-well, to purchase assets, goods, securities or services, to take-or-pay, or to maintain financial statement conditions or otherwise) or (ii) entered into for the purpose of assuring in any other manner the obligee of such Debt of the payment
thereof or to protect such obligee against loss in respect thereof (in whole or in part); provided that the term “Guarantee” shall not include endorsements for collection or deposit in the ordinary course of business. The term
“Guarantee” used as a verb has a corresponding meaning. 
  
 “Interest Period” means, with respect to each LIBOR Loan, the period commencing on the date of such Borrowing and ending 1, 2, 3, 6, 9 or 12 months thereafter, as the Borrower may elect in the applicable Notice of
Borrowing; provided that: 
  

	 	(i)	any Interest Period which would otherwise end on a day which is not a Business Day shall be extended to the next succeeding Business Day unless such Business Day falls in another
calendar month, in which case such Interest Period shall end on the next preceding Business Day; 

  

	 	(ii)	any Interest Period which begins on the last Business Day of a calendar month (or on a day for which there is no numerically corresponding day in the calendar month at the end of
such Interest Period) shall, subject to clause (iii) below, end on the last Business Day of a calendar month; and 

  

	 	(iii)	any Interest Period which would otherwise end after the Termination Date shall end on the Termination Date. 

  
 “Internal Revenue Code” means the Internal Revenue Code of
1986, as amended, or any successor statute. 
  
 “Investment” means any investment in any Person, whether by means of share purchase, capital contribution, loan, time deposit or otherwise. 
  
 “Issuance Request” shall have the meaning set forth in Section 2.15.4. 
  
 “JRH Biosciences” means JRH Biosciences Limited, a company
incorporated in England and Wales, JRH Biosciences Pty Ltd., a company incorporated in Australia, CSL US Inc., a Delaware corporation, and JRH Biosciences, Inc., a Delaware corporation. 
  
 “Lender” means each lender listed on the signature pages hereof, each Assignee which becomes a Lender
pursuant to Section 9.06(c), and their respective successors and assigns. 
  

 6 

 “Lending Office” means the LIBOR Lending Office or Base Rate Lending Office, as
applicable. 
  
 “Letter of Credit” means a Letter
of Credit issued pursuant to Section 2.15. 
  
 “Letter of Credit Expiry Date” means, with respect to any Letter of Credit, the date which is one (1) year after the date of issuance therefor. 
  
 “Letter of Credit Issuer” means Wells Fargo, as issuer of the Letters of Credit. 
  
 “Letter of Credit Issuer-Related Persons” means the Letter
of Credit Issuer (including any successor Administrative Agent), together with its Affiliates, and the officers, directors, employees, agents and attorneys-in-fact of such Persons and Affiliates. 
  
 “Letter of Credit Obligations” means, as at the time of
determination thereof, the sum of (a) the Reimbursement Obligations then outstanding, and (b) the aggregate undrawn face amount of the then outstanding Letters of Credit. 
  
 “Letter of Credit Sublimit” means an aggregate amount of $50,000,000. 
  
 “LIBOR Base Rate” means, with respect to LIBOR Loans for the
relevant Interest Period, the rate determined by the Administrative Agent to be the rate at which Wells Fargo offers to place deposits in U.S. dollars with first-class banks in the London interbank market at approximately 11:00 a.m. (London time)
two Business Days prior to the first day of such Interest Period, in the approximate amount of Wells Fargo’s relevant LIBOR Loan and having a maturity equal to such Interest Period. 
  
 “LIBOR Lending Office” means, as to each Lender, its office, branch or affiliate located at its address set
forth in its Administrative Questionnaire (or identified in its Administrative Questionnaire as its LIBOR Lending Office) or such other office, branch or affiliate of such Lender as it may hereafter designate as its LIBOR Lending Office by notice to
the Borrower and the Administrative Agent. 
  
 “LIBOR
Loan” means a Loan bearing interest at the LIBOR Rate. 
  
 “LIBOR Margin” means, with respect to LIBOR Loans at any time, the percentage rate per annum which is applicable at such time with respect to LIBOR Loans as set forth in the Pricing Schedule. 
  
 “LIBOR Rate” means, with respect to LIBOR Loans for the
relevant Interest Period, the sum of (i) the quotient of (a) the LIBOR Base Rate applicable to such Interest Period, divided by (b) one minus the Reserve Requirement (expressed as a decimal) applicable to such Interest Period, plus (ii) the LIBOR
Margin. The LIBOR Rate shall be rounded to the next higher multiple of 1/16 of 1% if the rate is not such a multiple. 
  

 7 

 “Lien” means, with respect to any asset, any mortgage, lien, pledge, security interest
or encumbrance of any kind in respect of such asset, including any conditional sale or other title retention agreement. 
  
 “Loan” means a Revolving Loan or Term Loan, as the case may be. 
  
 “Loan Document” means this Agreement, the Fee Letters and any Notes issued hereunder. 
  
 “Material Adverse Effect” means a material adverse effect
on: (i) the business, operations, affairs, financial condition, assets or properties of the Borrower and its Subsidiaries taken as a whole; (ii) the ability of the Borrower to perform its obligations under the Loan Documents; or (iii) the legality,
validity or enforceability of the Loan Documents. 
  
 “Material Debt” means Debt (other than the Notes) of the Borrower and/or one or more of its Subsidiaries, arising in one or more related or unrelated transactions, in an aggregate principal amount exceeding $30,000,000.

  
 “Material Plan” means at any time a Plan or
Plans having aggregate Unfunded Liabilities in excess of $10,000,000. 
  
 “Moody’s” means Moody’s Investors Service, Inc. or any successor thereto. 
  
 “Multiemployer Plan” means at any time an employee pension benefit plan within the meaning of Section 4001(a) (3) of ERISA to which any
member of the ERISA Group is then making or accruing an obligation to make contributions or has within the preceding five plan years made contributions, including for these purposes any Person which ceased to be a member of the ERISA Group during
such five-year period. 
  
 “Notes” means the
Revolving Notes and the Term Notes, and “Note” means any of the Revolving Notes or Term Notes. 
  
 “Notice of Borrowing” means a Notice of Borrowing (as defined in Section 2.02(a)) executed by a Senior Financial Officer.

  
 “OFAC” means the United States Department of
the Treasury’s Office of Foreign Assets Control. 
  
 “Obligations” means all unpaid principal of and accrued and unpaid interest on the Loans, all Letter of Credit Obligations, and all accrued and unpaid fees, expenses, reimbursements, indemnities and other obligations of the
Borrower to the Lenders or to any Lender, the Administrative Agent or any indemnified party arising under the Loan Documents. 
  
 “Parent” means, with respect to any Lender, any Person controlling (as defined under the definition of “Affiliate” herein) such
Lender. 
  

 8 

 “Participant” has the meaning set forth in Section 9.06(b). 
  
 “Payment Office” means the main office of the Administrative
Agent located in San Francisco, California. 
  
 “PBGC” means the Pension Benefit Guaranty Corporation or any entity succeeding to any or all of its functions under ERISA. 
  
 “Permitted Disposition” has the meaning set forth in Section 5.08(c). 
  
 “Person” means an individual, a corporation, a partnership,
a limited liability company, an association, a trust or any other entity or organization, including a government or political subdivision or an agency or instrumentality thereof. 
  
 “Plan” means at any time an employee pension benefit plan (other than a Multiemployer Plan) which is
covered by Title IV of ERISA or subject to the minimum funding standards under Section 412 of the Internal Revenue Code and either (i) is maintained, or contributed to, by any member of the ERISA Group for employees of any member of the ERISA Group
or (ii) has at any time within the preceding five years been maintained, or contributed to, by any Person which was at such time a member of the ERISA Group for employees of any Person which was at such time a member of the ERISA Group. 

 
 “Pricing Schedule” means the Pricing Schedule attached
hereto. 
  
 “Prime Rate” means at any time the
rate of interest per annum most recently announced within Wells Fargo at its principal office in San Francisco, California as its Prime Rate, with the understanding that Wells Fargo’s Prime Rate is one of its base rates and serves as the
basis upon which effective rates of interest are calculated for those loans making reference thereto and is evidenced by the recording thereof after its announcement in such internal publication or publications as Wells Fargo may designate. Each
change in the Prime Rate shall be effective on the day the change is announced within Wells Fargo. 
  
 “Register” has the meaning set forth in Section 9.06(f). 
  
 “Regulation D” means Regulation D of the Board of Governors of the Federal Reserve System as from time to
time in effect and any successor thereto or other regulation or official interpretation of said Board of Governors relating to reserve requirements applicable to member banks of the Federal Reserve System. 
  
 “Regulation U” means Regulation U of the Board of Governors
of the Federal Reserve System, as in effect from time to time and any successor thereto or other regulation or official interpretation of said Board of Governors relating to the extension of credit by banks for the purpose of purchasing or carrying
margin stocks applicable to member banks of the Federal Reserve System. 
  
 “Reimbursement Agreement” means a letter of credit application and reimbursement 

  

 9 

 
agreement in such form as the Letter of Credit Issuer may from time to time employ in the ordinary course of business. In the event of any inconsistency
between the Agreement and any Reimbursement Agreement, this Agreement shall govern. 
  
 “Reimbursement Obligations” means, at any time, the aggregate (without duplication) of the Obligations of the Borrower to the Lenders, the Letter of Credit Issuer and/or the Administrative Agent in
respect of all unreimbursed payments or disbursements made by the Lenders, the Letter of Credit Issuer and/or the Administrative Agent under or in respect of draws made under the Letters of Credit. 
  
 “Required Lenders” means at any time Lenders having at least
(i) 51% of the aggregate amount of the Commitments, and (ii) to the extent any Commitments have terminated, then 51% of the aggregate unpaid principal amount of Notes outstanding under such terminated Commitments. 
  
 “Reserve Requirement” means, with respect to an Interest
Period, the maximum, aggregate reserve requirement (including all basic, supplemental, marginal and other reserves) which is imposed under Regulation D on eurocurrency liabilities. 
  
 “Revolving Commitment” means, with respect to any Lender, the principal amount set forth opposite the name
of such Lender on Schedule 1.01 hereto or in any Assignment and Assumption Agreement under the caption “Amount of Revolving Commitment”, and “Revolving Commitments” means such commitments collectively, which
commitments equal $150,000,000 in the aggregate as of the Effective Date, as such amount may be changed from time to time pursuant to Section 2.08. 
  
 “Revolving Commitment Percentage” means, with respect to each Lender, the percentage equal to a fraction the numerator of which is the
amount of such Lender’s Revolving Commitment and the denominator of which is the aggregate amount of the Revolving Commitments of the Lenders. 
  
 “Revolving Loan” means a loan made by a Lender pursuant to Section 2.01 (a), which may be a Base Rate Loan or a LIBOR Loan.

  
 “Revolving Loan Availability Period” means
the period from and including the Effective Date to but not including the Revolving Loan Termination Date. 
  
 “Revolving Loan Termination Date” means February 23, 2010. 
  
 “Revolving Note” means promissory notes of the Borrower, substantially in the form of Exhibit A-1
hereto, evidencing the obligation of the Borrower to repay the Revolving Loans, and “Revolving Note” means any one of such promissory notes issued hereunder, as the same may be amended, supplemented or otherwise modified from time
to time. 
  
 “Sale and Leaseback Transaction” of
any Person means an arrangement with any lender or investor or to which such lender or investor is a party providing for the leasing by such Person 

  

 10 

 
of any property that has been or is being sold, conveyed, transferred or otherwise disposed of by such Person to such lender or investor or to any Person to
whom funds have been or are to be advanced by such lender or investor on the security of such property. 
  
 “S&P” means Standard & Poor’s Ratings Group, a division of The McGraw-Hill Companies, Inc., and any successor thereto.

  
 “Securities Exchange Act” means the
Securities Exchange Act of 1934, as amended. 
  
 “Senior
Financial Officer” means the chief financial officer, principal accounting officer, treasurer or controller of the Borrower. 
  
 “Subsidiary” of a Person means any corporation, association, partnership, limited liability company, joint venture or other business
entity of which more than 50% of the voting stock, membership interests or other equity interests (in the case of Persons other than corporations), is owned or controlled directly or indirectly by the Person, or one or more of the Subsidiaries of
the Person, or a combination thereof. Unless the context otherwise clearly requires, references herein to a “Subsidiary” refer to a Subsidiary of the Borrower or one of the Subsidiaries. 
  
 “Swaps” means, with respect to any Person, payment
obligations with respect to interest rate swaps, currency swaps and similar obligations (other than forward currency contracts) obligating such Person to make payments, whether periodically or upon the happening of a contingency. For the purposes of
this Agreement, the amount of the obligation under any Swap shall be the amount determined in respect thereof as of the end of the then most recently ended fiscal quarter of such Person, based on the assumption that such Swap had terminated at the
end of such fiscal quarter, and in making such determination, if any agreement relating to such Swap provides for the netting of amounts payable by and to such Person thereunder or if any such agreement provides for the simultaneous payment of
amounts by and to such Person, then and in each such case, the amount of such obligations shall be the net amount so determined. 
  
 “Synthetic Lease Obligation” of any Person means the obligation to pay rent or other payment amounts under a lease of (or other
indebtedness arrangements conveying the right to use) real or personal property of such Person which may be classified and accounted for as an operating lease or off-balance sheet liability for accounting purposes but as a secured or unsecured loan
for tax purposes under the Internal Revenue Code. 
  
 “Term Commitment” means, with respect to any Lender, the principal amount set forth opposite the name of such Lender on Schedule 1.01 hereto or in any Assignment and Assumption Agreement under the caption
“Amount of Term Commitment”, and “Term Commitments” means such commitments collectively, which commitments equal $150,000,000 in the aggregate as of the Effective Date, as such amount may be changed from time to time
pursuant to Section 2.08. 
  
 “Term Commitment
Percentage” means, with respect to each Lender, the percentage equal to a fraction the numerator of which is the amount of such Lender’s Term Commitment and the denominator of which is the aggregate amount of the Term Commitments of
the Lenders. 
  

 11 

 “Term Loan” means a loan made by a Lender pursuant to Section 2.01 (b), which may
be a Base Rate Loan or a LIBOR Loan. 
  
 “Term Loan
Availability Period” means the period from and including the Effective Date to but not including June 1, 2005. 
  
 “Term Loan Termination Date” means February 23, 2008. 
  
 “Term Note” means promissory notes of the Borrower, substantially in the form of Exhibit A-2 hereto,
evidencing the obligation of the Borrower to repay the Term Loans, and “Term Note” means any one of such promissory notes issued hereunder, as the same may be amended, supplemented or otherwise modified from time to time.

  
 “Total Revolving Commitment” means, with
respect to any Lender, its Revolving Commitment under this Agreement plus its commitment pursuant to the 5-Year Agreement, and “Total Revolving Commitments” means such commitments collectively for all Lenders, which
commitments equal $300,000,000 in the aggregate as of the Effective Date, as such amount may be changed from time to time pursuant to Section 2.08 hereof or Section 2.08 of the 5-Year Agreement. 
  
 “Unfunded Liabilities” means, with respect to any Plan at
any time, the amount (if any) by which (i) the present value of all benefits under such Plan exceeds (ii) the fair market value of all Plan assets allocable to such benefits (excluding any accrued but unpaid contributions), all determined as of the
then most recent valuation date for such Plan, but only to the extent that such excess represents a potential liability of a member of the ERISA Group to the PBGC or any other Person under Title IV of ERISA. 
  
 “Utilization Fee Period” means any period of time after the
date hereof during which the used portion of the Total Revolving Commitments exceeds 50% of the Total Revolving Commitments. 
  
 “Utilization Fee Rate” has the meaning set forth in Section 2.07(b). 
  
 “Voting Stock” means capital stock of any class or classes (however designated) having ordinary voting
power for the election of directors of the Borrower, other than stock having such power only by reason of the happening of a contingency. 
  
 “Wells Fargo” means Wells Fargo Bank, National Association, in its individual capacity. 
  
 Section 1.02 Accounting Terms and Determinations. Unless otherwise
specified herein, all accounting terms used herein shall be interpreted, all accounting determinations hereunder shall be made, and all financial statements required to be delivered hereunder shall be prepared in accordance with generally accepted
accounting principles as in effect from time to time, applied on a basis consistent (except for changes concurred in by the Borrower’s independent public accountants) with the most recent audited consolidated financial statements of the
Borrower and its Subsidiaries delivered to the Lenders; provided that, if the Borrower 
  

 12 

 notifies the Administrative Agent that the Borrower wishes to amend any covenant in Article V to eliminate the
effect of any change in generally accepted accounting principles on the operation of such covenant (or if the Administrative Agent notifies the Borrower that the Required Lenders wish to amend Article V for such purpose), then the
Borrower’s compliance with such covenant shall be determined on the basis of generally accepted accounting principles in effect immediately before the relevant change in generally accepted accounting principles became effective, until either
such notice is withdrawn or such covenant is amended in a manner satisfactory to the Borrower and the Required Lenders. 
  
 Section 1.03 Types of Borrowings. The term “Borrowing” denotes the aggregation of Loans of one or more Lenders to be made to the Borrower
pursuant to Article II on a single date and, in the case of LIBOR Loans, for a single Interest Period. Borrowings may be classified for purposes of this Agreement by reference to the pricing of Loans comprising such Borrowing
(e.g., a “Base Rate Borrowing” is a Borrowing comprised of Base Rate Loans, and a “LIBOR Borrowing” is a Borrowing comprised of LIBOR Loans). 
  
 ARTICLE II 
  
 THE CREDITS 
  
 Section 2.01 Commitments to Lend. 
  
 (a) Revolving Loans. During the Revolving Loan Availability Period, each Lender severally agrees, on the terms and conditions set forth in this
Agreement, to make Revolving Loans to the Borrower pursuant to this Section 2.01(a) from time to time in amounts such that the aggregate principal amount of Revolving Loans by such Lender shall not exceed the amount of its Revolving
Commitment less such Lender’s Revolving Commitment Percentage of all Letter of Credit Obligations outstanding at such time. Each Borrowing under this Section 2.01(a) shall be in an aggregate principal amount of $5,000,000 or any larger
multiple of $1,000,000 (or in the remaining unused portion of the Revolving Commitments) and shall be made from the several Lenders ratably in proportion to their respective Revolving Commitments. Within the foregoing limits, the Borrower may borrow
under this Section 2.01, repay, or to the extent permitted by Section 2.10, prepay Loans and reborrow at any time during the Revolving Loan Availability Period under this Section 2.01(a). 
  
 (b) Term Loans. During the Term Loan Availability Period, each Lender
severally agrees, on the terms and conditions set forth in this Agreement, to make Term Loans to the Borrower pursuant to this Section 2.01(b) from time to time in amounts such that the aggregate principal amount of Term Loans by such Lender
shall not exceed the amount of its Term Commitment. Each Borrowing under this Section 2.01(b) shall be made from the several Lenders ratably in proportion to their respective Term Loan Commitments. Borrower shall not be entitled to more than
two (2) separate Borrowings from the Lenders under this Section 2.01(b). Amounts repaid on the Term Loans may not be reborrowed. 
  
 Section 2.02 Notice of Borrowings. 
  
 (a) Notice of Borrowings. The Borrower shall give the Administrative Agent 
  

 13 

 notice (a “Notice of Borrowing”) not later than (x) 12:00 noon (Chicago time) on the date of each Base
Rate Borrowing and (y) 1:00 P.M. (Chicago time) on the third Business Day before each LIBOR Borrowing, specifying: 
  
 (i) the date of such Borrowing, which shall be a Business Day 
  
 (ii) the aggregate amount of such Borrowing, 
  
 (iii) whether the Loans comprising such Borrowing are to be Revolving Loans or Term Loans, 
  
 (iv) whether the Loans comprising such Borrowing are to be
Base Rate Loans or LIBOR Loans, and 
  
 (v) in
the case of a LIBOR Borrowing, the duration of the Interest Period applicable thereto, subject to the provisions of the definition of Interest Period. 
  
 (b) Conversion and Continuation of Outstanding Advances. Base Rate Borrowings shall continue as Base Rate Borrowings unless and until such Base
Rate Borrowings are converted into LIBOR Loans pursuant to this Section 2.02 or are repaid in accordance with this Article II. Each LIBOR Borrowing shall continue as a LIBOR Borrowing until the end of the then applicable Interest
Period therefor, at which time such LIBOR Borrowing shall be automatically converted into a Base Rate Borrowing unless (x) such LIBOR Borrowing is or was repaid in accordance with this Article II or (y) the Borrower shall have given the
Administrative Agent a Conversion/Continuation Notice (as defined below) requesting that, at the end of such Interest Period, such LIBOR Borrowing continue as a LIBOR Borrowing for the same or another Interest Period. The Borrower may elect from
time to time to convert all or any part of a Base Rate Borrowing into a LIBOR Borrowing, provided that the resulting Borrowings shall be in a minimum amount of $5,000,000. The Borrower shall give the Administrative Agent irrevocable notice (a
“Conversion/Continuation Notice”) of each conversion of a Base Rate Borrowing into a LIBOR Borrowing or continuation of a LIBOR Borrowing not later than 1:00 P.M. (Chicago time) at least three Business Days prior to the date of the
requested conversion or continuation, specifying: 
  
 (i) the requested date, which shall be a Business Day, of such conversion or continuation, 
  
 (ii) the aggregate amount of the Borrowing which is to be converted or continued and whether such Borrowing is a Base Rate Borrowing or a
LIBOR Borrowing, and 
  
 (iii) the amount of
such Borrowing which is to be converted into or continued as a LIBOR Borrowing and the duration of the Interest Period applicable thereto. 
  
 In no event shall Borrower be permitted more than eight (8) Interest Periods outstanding at any one time under this Agreement. 
  

 14 

 Section 2.03 Notice to Lenders; Funding of Loans. 
  
 (a) Upon receipt of a Notice of Borrowing the Administrative Agent shall
promptly notify each Lender of the contents thereof and of such Lender’s share of such Borrowing and such Notice of Borrowing shall not thereafter be revocable by the Borrower. 
  
 (b) Not later than 2:00 P.M. (Chicago time) on the date of each Borrowing, each Lender therein shall (except as provided in
subsection (c) of this Section) make available its share of such Borrowing, in Federal or other funds immediately available in San Francisco, California, to the Administrative Agent at its address specified in or pursuant to Section 9.01.
Unless the Administrative Agent determines that any applicable condition specified in Article III has not been satisfied, the Administrative Agent will make the funds so received from the Lenders available to the Borrower at the
Administrative Agent’s aforesaid address. 
  
 (c) If new
Loans are to be made hereunder on a day on which the Borrower is to prepay or repay all or any part of outstanding Loans, the Lenders shall apply the proceeds of the new Loans to make such repayment and only an amount equal to the difference (if
any) between the amount being borrowed and the amount being prepaid or repaid shall be made available by the Lenders to the Administrative Agent as provided in subsection (b), or remitted by the Borrower to the Administrative Agent as provided in
Section 2.12, as the case may be. In such case, the incurrence of such new Loans and the prepayment or repayment of such outstanding Loans shall be deemed to have occurred simultaneously. 
  
 (d) Unless the Administrative Agent shall have received notice from a Lender
prior to the date of any Borrowing that such Lender will not make available to the Administrative Agent such Lender’s share of such Borrowing, the Administrative Agent may assume that such Lender has made such share available to the
Administrative Agent on the date of such Borrowing in accordance with subsections (b) and (c) of this Section 2.03 and the Administrative Agent may, in reliance upon such assumption, make available to the Borrower on such date a corresponding
amount. If and to the extent that such Lender shall not have so made such share available to the Administrative Agent, such Lender and the Borrower severally agree to repay to the Administrative Agent forthwith on demand such corresponding amount
together with interest thereon, for each day from the date such amount is made available to the Borrower until the date such amount is repaid to the Administrative Agent, at (i) in the case of the Borrower, a rate per annum equal to the
interest rate applicable thereto pursuant to Section 2.06 and (ii) in the case of such Lender, the Federal Funds Effective Rate. If such Lender shall repay to the Administrative Agent such corresponding amount, such amount so repaid shall
constitute such Lender’s Loan included in such Borrowing for purposes of this Agreement. 
  
 Section 2.04 Notes. 
  
 (a) The Revolving Loans of each Lender shall be evidenced by a single Revolving Note payable to the order of such Lender for the account of its Applicable Lending Office in an amount equal to the aggregate unpaid principal amount of such
Lender’s Revolving Commitment. The Term Loans of each Lender shall be evidenced by a single Term Note payable to the order of such Lender for the account of its Applicable Lending Office in an amount equal to the aggregate unpaid principal
amount of such Lender’s Term Commitment. 
  

 15 

 (b) Upon receipt of each Lender’s Note pursuant to Section 3.01(b), the Administrative Agent
shall deliver such Note to such Lender. Each Lender shall record the date, amount, type and maturity of each Loan made by it and the date and amount of each payment of principal made by the Borrower with respect thereto, and prior to any transfer of
its Note shall endorse on the schedule forming a part thereof appropriate notations to evidence the foregoing information with respect to each such Loan then outstanding; provided that the failure of any Lender to make any such recordation or
endorsement shall not affect the obligations of the Borrower hereunder or under the Notes. Each Lender is hereby irrevocably authorized by the Borrower so to endorse each of its Notes and to attach to and make a part of each of its Notes a
continuation of any such schedule as and when required. 
  
 Section 2.05 Maturity of Loans. Each Revolving Credit Loan shall mature, and the principal amount thereof and all accrued and unpaid interest thereon shall be due and payable in full, on the Revolving Loan Termination Date. Each Term
Loan shall mature, and the principal amount thereof and all accrued and unpaid interest thereon shall be due and payable in full, on the Term Loan Termination Date. 
  
 Section 2.06 Interest Rates. 
  
 (a) Each Base Rate Loan shall bear interest on the outstanding principal amount thereof, for each day from the date such
Loan is made until it becomes due or is converted to a LIBOR Loan, at a rate per annum equal to the Base Rate for such day. Such interest shall be payable quarterly in arrears on the last Business Day of each calendar quarter. Any overdue
principal of or interest on any Base Rate Loan shall bear interest, payable on demand, for each day from and including the date payment thereof was due to, but excluding, the date of the actual payment, at a rate per annum equal to the sum of
2% plus the Base Rate for such day. 
  
 (b) Each LIBOR Loan shall
bear interest on the outstanding principal amount thereof, for each Interest Period applicable thereto, at a rate per annum equal to the applicable LIBOR Rate. Such interest shall be payable for each Interest Period on the last day thereof
and, if such Interest Period is longer than three months, at intervals of three months after the first day thereof. Any overdue principal of or interest on any LIBOR Loan shall bear interest, payable on demand, for each day from and including the
date payment thereof was due to, but excluding, the date of actual payment, at a rate per annum equal to the sum of two percent (2%) plus the higher of (i) the Base Rate for such day, or (ii) the LIBOR Rate for the applicable Interest Period,
and thereafter, at a rate per annum equal to the sum of two percent (2%) plus the Base Rate for such day. 
  
 (c) The Administrative Agent shall determine each interest rate applicable to the Loans hereunder. The Administrative Agent shall give prompt notice to
the Borrower and the participating Lenders by telex or facsimile of each rate of interest so determined, and its determination thereof shall be conclusive in the absence of manifest error. 
  
 Section 2.07 Loan Fees. 
  
 (a) Facility Fee. The Borrower shall pay to the Administrative Agent
for the 
  

 16 

 account of the Lenders ratably a facility fee at the applicable percentage rate per annum as set forth in the
Pricing Schedule (the “Facility Fee Rate”). Such facility fee shall accrue each day from and including the Effective Date to but excluding the Termination Date, on the aggregate amount of the Commitments (whether used or unused) on
such date. 
  
 (b) Utilization Fee. The Borrower shall pay
to the Administrative Agent for the account of the Lenders ratably a per annum utilization fee at the applicable percentage rate as set forth in the Pricing Schedule (the “Utilization Fee Rate”). Such utilization fee shall
accrue each day during the Utilization Fee Period on the aggregate amount of the used portion of the Total Revolving Commitments. 
  
 (c) Administrative Agent’s and Arrangers’ Fees. The Borrower shall pay to the Administrative Agent and the Joint Lead Arrangers, for
their own accounts, as and when due the fees set forth in the Fee Letters. 
  
 (d) Payments. Accrued fees under clauses (a) and (b) of this Section shall be payable quarterly in arrears on the last Business Day of each March, June, September and December and on the Termination Date.

  
 Section 2.08 Optional Termination, Reduction or Increase of
Commitments. 
  
 (a) The Borrower may, upon at least three
(3) Business Days’ notice to the Administrative Agent, terminate the Revolving Commitments at any time, if no Revolving Loans or Letter of Credit Obligations are outstanding at such time, or terminate the Term Commitments, if no Term Loans are
outstanding at such time. 
  
 (b) The Borrower may, upon at least
three (3) Business Days’ notice to the Administrative Agent, ratably reduce from time to time by an aggregate amount of $10,000,000 or any larger multiple of $10,000,000 (i) the aggregate amount of the Revolving Commitments in excess of the
aggregate outstanding principal amount of the Revolving Loans and Letter of Credit Obligations, or (ii) the aggregate amount of the Term Commitments in excess of the aggregate outstanding principal amount of the Term Loans. Each such termination or
reduction shall be permanent. 
  
 (c) (i) Borrower may at any
time, by notice to the Administrative Agent, propose that the Revolving Commitments be increased (the amount of such increase being a “Revolving Commitment Increase”), effective as at a date prior to the Revolving Loan Termination Date (an
“Increase Date”) as to which agreement is to be reached by an earlier date specified in such notice (a “Increase Commitment Date”); provided, however, that (a) the Borrower may not propose more than two Revolving
Commitment Increases in any calendar year, (b) the Borrower shall cause the Increase Date to occur on a date which is the end of the applicable Interest Period for all Loans then outstanding (and for this purpose the Borrower shall cause Interest
Periods to be selected in such manner to effect the foregoing), (c) the minimum proposed Revolving Commitment Increase per notice shall be $10,000,000, (d) in no event shall the Revolving Commitments at any time exceed $300,000,000, (e) the Borrower
shall have delivered to the Administrative Agent all necessary corporate resolutions authorizing such Revolving Commitment Increase and any related borrowings, and (f) no Default shall have 
  

 17 

 occurred and be continuing on such Increase Date. The Administrative Agent shall notify the Lenders thereof promptly upon
its receipt of any such notice. Each of the Lenders shall have the opportunity to increase its Revolving Commitment by a ratable amount of the proposed Revolving Commitment Increase. If one or more of the Lenders is not willing to increase its
Revolving Commitment on a ratable basis (provided, that failure of a Lender to respond shall be deemed an indication of unwillingness), then the Administrative Agent agrees that it will cooperate with the Borrower in discussions with the Lenders and
other Eligible Lenders with a view to arranging the proposed Revolving Commitment Increase through the increase of the Revolving Commitments of, first, one or more of the Lenders (each such Lender that is willing to increase its Commitment hereunder
being an “Increasing Lender”) and, if the existing Lenders are not willing, in the aggregate, to increase their Revolving Commitments by the amount of the requested Revolving Commitment Increase, then, subject to the provisions of
applicable law, by the addition of one or more other Eligible Lenders reasonably acceptable to the Borrower and the Administrative Agent (each an “Assuming Lender”) as Lenders and as parties to this Agreement. If the Increasing Lenders
agree to increase their respective Revolving Commitments by an aggregate amount in excess of the proposed Revolving Commitment Increase, the proposed Revolving Commitment Increase shall be allocated among such Increasing Lenders in proportion to
their respective Revolving Commitments immediately prior to the Increase Date. If agreement is reached on or prior to the applicable Increase Commitment Date with any Increasing Lenders and Assuming Lenders as to a Revolving Commitment Increase
(which may be less than but not greater than specified in the applicable notice from the Borrower), such agreement to be evidenced by a notice in reasonable detail from the Administrative Agent to the Borrower on or prior to the applicable Increase
Commitment Date, such Assuming Lenders, if any, shall become Lenders hereunder as of the applicable Increase Date and the Revolving Commitments of such Increasing Lenders and such Assuming Lenders shall become or be, as the case may be, as of the
Increase Date, the amounts specified in such notice; provided, that: 
  
 (w) the Administrative Agent shall have received (with copies for each Lender, including each such Assuming Lender) by no later than 10:00 A.M. (Chicago time) on the applicable Increase Date a certificate executed by
both an Authorized Officer and the secretary of the Borrower, stating that the resolutions adopted by the Board of Directors of the Borrower prior to such Increase Date authorizing the Borrower to borrow Revolving Loans pursuant to this Agreement
from time to time in an aggregate principal amount at any one time outstanding not in excess of $300,000,000 remain in full force and effect and have not been modified or rescinded or attaching and certifying, if applicable, any amendments to such
resolutions or supplemental borrowing resolutions; 
  
 (x) The Administrative Agent shall have received from the Borrower duly executed and delivered (1) Revolving Notes payable to the order of each Assuming Lender, if any, and each Increasing Lender, dated as of the applicable Increase Date,
in a principal amount equal to such Lender’s Revolving Commitment after giving effect to the relevant Revolving Commitment Increase, and substantially in the form of Exhibit A-1. (The Administrative Agent, upon receipt of such Revolving
Notes, shall promptly deliver such Revolving Notes to the respective Assuming Lenders and Increasing Lenders, and upon receipt of such Revolving Notes, each Increasing Lender agrees to return to the Borrower the Revolving Notes theretofore issued to
it pursuant to this Agreement); 
  

 18 

 (y) each such Assuming Lender shall have delivered to the Administrative Agent, by no
later than 10:00 A.M. (Chicago time) on such Increase Date, an appropriate Lender Assumption Agreement in substantially the form of Exhibit G hereto, duly executed by such Assuming Lender and the Borrower; and 
  
 (z) each such Increasing Lender shall have delivered to the
Administrative Agent by, not later than 10:00 A.M. (Chicago time) on such Increase Date, a confirmation in writing reasonably satisfactory to the Administrative Agent as to its increased Revolving Commitment. 
  
 (ii) In the event that the Administrative Agent shall have
received notice from the Borrower as to its agreement to a Revolving Commitment Increase on or prior to the applicable Increase Commitment Date and each of the actions provided for in clauses (i)(w) through (i)(z) above shall have occurred prior to
10:00 A.M. (Chicago time) on the applicable Increase Date to the satisfaction of the Administrative Agent, the Administrative Agent shall promptly notify the Lenders (including any Assuming Lenders) and the Borrower of the occurrence of such
Revolving Commitment Increase and shall record in its records the relevant information with respect to each Increasing Lender and Assuming Lender. Each Increasing Lender and each Assuming Lender shall, before 2:00 P.M. (Chicago time) on the
applicable Increase Date, make available to the Administrative Agent in accordance with the provisions of Section 2.03(b), in same day funds, in the case of such Assuming Lender, an amount equal to such Assuming Lender’s ratable portion
of the Revolving Commitments then outstanding (calculated based on its Revolving Commitment Percentage), or, in the case of an Increasing Lender, an amount equal to the excess of (a) such Increasing Lender’s ratable portion of the Revolving
Commitments then outstanding after giving effect to the relevant Revolving Commitment Increase over (b) such Increasing Lender’s ratable portion of the Revolving Commitments then outstanding before giving effect to the relevant Revolving
Commitment Increase. After the Administrative Agent’s receipt of such funds from each such Increasing Lender and each such Assuming Lender, the Administrative Agent will, if necessary, promptly thereafter cause to be distributed like funds to
the other Lenders for the account of their respective applicable Lending Office in an amount to each other Lender such that the aggregate amount of the outstanding Revolving Commitments owing to each Lender after giving effect to such distribution
equals such Lender’s ratable portion of the Revolving Commitments then outstanding after giving effect to the relevant Revolving Commitment Increase. 
  
 (iii) In the event that the Administrative Agent shall not have received notice from the Borrower as to such agreement on or prior to the
applicable Increase Commitment Date or the Borrower shall, by notice to the Administrative Agent prior to the applicable Increase Date, withdraw its proposal for a Revolving Commitment Increase or any of the actions provided for above in clauses
(i)(w) through (i)(z) shall not have occurred by 10:00 A.M. (Chicago time) on such Increase Date, such proposal by the Borrower shall be deemed not to have been made. In such event, any actions theretofore taken under clauses (i)(w) through (i)(z)
above shall be deemed to be of no effect and all the rights and obligations of the parties shall continue as if no such proposal had been made. 
  

 19 

 Section 2.09 Mandatory Termination of Commitments. The Commitments shall terminate on the
Termination Date, and any Loans then outstanding (together with accrued interest thereon) shall be due and payable on such date. 
  
 Section 2.10 Prepayments. 
  
 (a) The Borrower may, (i) upon at least one (1) Business Day’s notice to the Administrative Agent, prepay any Base Rate Borrowing and (ii) upon at
least three (3) Business Days’ notice to the Administrative Agent, prepay, subject to Section 2.12, any LIBOR Borrowing, in whole at any time, or from time to time in part in amounts aggregating $5,000,000 or any larger multiple of
$1,000,000, by paying the principal amount to be prepaid together with accrued interest thereon to the date of prepayment. Each such optional prepayment shall be applied to prepay ratably the Loans of the several Lenders included in such Borrowing.

  
 (b) Upon receipt of a notice of prepayment pursuant to this
Section, the Administrative Agent shall promptly notify each Lender of the contents thereof and of such Lender’s ratable share (if any) of such prepayment and such notice shall not thereafter be revocable by the Borrower; provided, however,
that the Borrower may reborrow Loans at any time during the Revolving Loan Availability Period subject to Section 2.01(a). 
  
 Section 2.11 General Provisions as to Payments. 
  
 (a) The Borrower shall make each payment of principal of, and interest on, the Loans and of fees hereunder, not later than Noon (Chicago time) on the date
when due, in Federal or other funds immediately available in San Francisco, California, to the Administrative Agent at its Payment Office without set-off, counterclaim or deduction of any kind. The Administrative Agent will promptly distribute to
each Lender its ratable share (if any) of each such payment received by the Administrative Agent for the account of the Lenders. Whenever any payment of principal of, or interest on, the Base Rate Loans or of fees shall be due on a day which is not
a Business Day, the date for payment thereof shall be extended to the next succeeding Business Day. Whenever any payment of principal of, or interest on, the LIBOR Loans shall be due on a day which is not a Business Day, the date for payment thereof
shall be extended to the next succeeding Business Day unless such Business Day falls in another calendar month, in which case the date for payment thereof shall be the next preceding Business Day. If the date for any payment of principal is extended
by operation of law or otherwise, interest thereon shall be payable for such extended time. All payments by Borrower hereunder shall be made without deduction, set-off, recoupment or counterclaim of any kind, subject to compliance with Section
2.14 of this Agreement. 
  
 (b) Unless the Administrative
Agent shall have received notice from the Borrower prior to the date on which any payment is due to the Lenders hereunder that the Borrower will not make such payment in full, the Administrative Agent may assume that the Borrower has made such
payment in full to the Administrative Agent on such date and the Administrative Agent may, in reliance upon such assumption, cause to be distributed to each Lender on such due date an amount equal to the amount then due such Lender. If and to the
extent that the Borrower shall not have so made such payment, each Lender shall repay to the Administrative Agent forthwith on demand such amount distributed to such Lender together with 
  

 20 

 interest thereon, for each day from the date such amount is distributed to such Lender until the date such Lender repays
such amount to the Administrative Agent, at the Federal Funds Effective Rate. 
  
 Section 2.12 Funding Losses. If the Borrower makes any payment of principal with respect to any LIBOR Loan or any LIBOR Loan is converted to a different type of Loan (pursuant to Article II, VI or
VIII or otherwise) on any day other than the last day of the Interest Period applicable thereto, or if the Borrower fails to borrow any LIBOR Loans after notice has been given to any Lender in accordance with Section 2.03(a), or fails
to borrow, prepay, convert or continue any LIBOR Loan after notice has been given to any Lender in accordance with Section 2.02, 2.03(a) or 2.10(a), or Article VIII, the Borrower shall reimburse each Lender within 15 days
after demand for any resulting loss or expense incurred by it (or by an existing or prospective Participant in the related Loan), including (without limitation) any loss incurred in obtaining, liquidating or employing deposits from third parties,
but excluding loss of margin for the period after any such payment or failure to borrow; provided that such Lender shall have delivered to the Borrower a certificate explaining in reasonable detail the amount of such loss or expense, which
certificate shall be conclusive in the absence of manifest error. 
  
 Section 2.13 Computation of Interest and Fees. All interest and fees hereunder shall be computed on the basis of a year of 360 days, provided that interest on Base Rate Loans shall be computed on the basis of a year of 365
days or 366 days (as applicable), and in any case shall be paid for the actual number of days elapsed (including the first day but excluding the last day). 
  
 Section 2.14 Withholding Tax Exemption. 
  
 (a) At least five Business Days prior to the first date on which interest or fees are payable hereunder for the account of any Lender, each Lender that is
not incorporated under the laws of the United States of America or a state thereof agrees that it will deliver to each of the Borrower and the Administrative Agent two duly completed copies of United States Internal Revenue Service Form 1001 or 4224
(or successor forms), certifying in either case that such Lender is entitled to receive payments under this Agreement and the Notes without deduction or withholding of any United States federal income taxes. Each Lender which so delivers a Form 1001
or 4224 (or successor forms) further undertakes to deliver to each of the Borrower and the Administrative Agent two additional copies of such forms (or successor forms) on or before the date that such form expires or becomes obsolete or after the
occurrence of any event requiring a change in the most recent form so delivered by it, and such amendments thereto or extensions or renewals thereof as may be reasonably requested by the Borrower or the Administrative Agent, in each case certifying
that such Lender is entitled to receive payments under this Agreement and the Notes without deduction or withholding of any United States federal income taxes, unless an event (including without limitation any change in treaty, law or regulation)
has occurred prior to the date on which any such delivery would otherwise be required which renders all such forms inapplicable or which would prevent such Lender from duly completing and delivering any such form with respect to it and such Lender
advises the Borrower and the Administrative Agent that it is not capable of receiving payments without any deduction or withholding of United States federal income tax. 
  
 (b) If the U.S. Internal Revenue Service or any other governmental authority 
  

 21 

 of the United States or any other country or any political subdivision thereof asserts a claim that the Administrative
Agent did not properly withhold tax from amounts paid to or for the account of any Lender (because the appropriate form was not delivered or properly completed, because such Lender failed to notify the Administrative Agent of a change in
circumstances which rendered its exemption from withholding ineffective, or for any other reason), such Lender shall indemnify the Administrative Agent fully for all amounts paid, directly or indirectly, by the Administrative Agent as tax,
withholding thereof, or otherwise, including penalties and interest, and including taxes imposed by any jurisdiction on amounts payable to the Administrative Agent under this subsection, together with all costs and expenses related thereto
(including attorneys fees and time charges of attorneys for the Administrative Agent, which attorneys may be employees of the Administrative Agent). The obligations of the Lenders under this Section 2.14(b) shall survive the payment of the
Obligations and termination of this Agreement. 
  
 Section 2.15
Letters of Credit. 
  
 Section 2.15.1 Issuance of
Letters of Credit. From and after the date hereof to but not including the fifth Business Day prior to Revolving Credit Termination Date, the Letter of Credit Issuer agrees, upon the terms and conditions set forth in this Agreement, to issue at
the request and for the account of the Borrower, one or more Letters of Credit; provided, however, that the Letter of Credit Issuer shall not be under any obligation to issue, and shall not issue, any Letter of Credit if: 

 
 (a) (i) any order, judgment or decree of any Governmental Authority with
jurisdiction over the Letter of Credit Issuer shall purport by its terms to enjoin or restrain such Letter of Credit Issuer from issuing such Letter of Credit, or any law or governmental rule, regulation, policy, guideline or directive (whether or
not having the force of law) from any Governmental Authority with jurisdiction over the Letter of Credit Issuer shall prohibit, or request that the Letter of Credit Issuer refrain from, the issuance of Letters of Credit in particular or shall impose
upon the Letter of Credit Issuer with respect to any Letter of Credit any restriction or reserve or capital requirement (for which the Letter of Credit Issuer is not otherwise compensated) or any unreimbursed loss, cost or expense which was not
applicable, in effect and known to the Letter of Credit Issuer as of the date of this Agreement and which the Letter of Credit Issuer in good faith deems material to it (the Letter of Credit Issuer shall promptly notify the Borrower of any event
which, in the judgment of the Letter of Credit Issuer, would preclude the issuance of a Letter of Credit pursuant to this clause (i)); (ii) one or more of the conditions to such issuance contained in Section 3.02 is not then satisfied; or
(iii) after giving effect to such issuance, the aggregate outstanding amount of the Letter of Credit Obligations would exceed the Letter of Credit Sublimit. 
  
 (b) the sum at any time of (A) the aggregate amount of Letter of Credit Obligations and (B) the aggregate principal balance of all outstanding Revolving
Loans exceed the Revolving Commitments; 
  
 (c) the expiration
date of any Letter of Credit (including, without limitation, Letters of Credit issued with an automatic “evergreen” provision providing for renewal absent advance notice by the Borrower or the Letter of Credit Issuer), or the date for
payment of any draft presented thereunder and accepted by the Letter of Credit Issuer, be later than the Letter of Credit Expiry Date; or 
  

 22 

 (d) any Letter of Credit is for a purpose not approved by the Letter of Credit Issuer in its reasonable
commercial discretion. 
  
 Section 2.15.2 Participating
Interests. Immediately upon the issuance by the Letter of Credit Issuer of a Letter of Credit in accordance with Section 2.15.4, each Lender shall be deemed to have irrevocably and unconditionally purchased and received from the Letter of
Credit Issuer, without recourse, representation or warranty, an undivided participation interest equal to its Revolving Commitment Percentage of the face amount of such Letter of Credit and each draw paid by the Letter of Credit Issuer thereunder.
Each Lender’s obligation to pay its proportionate share of all draws under the Letters of Credit, absent gross negligence or willful misconduct by the Letter of Credit Issuer in honoring any such draw, shall be absolute, unconditional and
irrevocable and in each case shall be made without counterclaim or set-off by such Lender. 
  
 Section 2.15.3 Letter of Credit Reimbursement Obligations. 
  
 (a) The Borrower agrees to pay to the Letter of Credit Issuer (i) on each date that any amount is drawn under each Letter of Credit a sum (and interest on
such sum as provided in clause (ii) below) equal to the amount so drawn plus all other charges and expenses with respect thereto specified in Section 2.15.6 or in the applicable Reimbursement Agreement and (ii) interest on any and all
amounts remaining unpaid under this Section 2.15.3 until payment in full at the Base Rate plus 2.00% per annum. The Borrower agrees to pay to the Letter of Credit Issuer the amount of all Reimbursement Obligations owing in respect of any
Letter of Credit immediately when due, under all circumstances, including, without limitation, any of the following circumstances: (w) any lack of validity or enforceability of this Agreement or any instrument executed pursuant hereto; (x) the
existence of any claim, set-off, defense or other right which the Borrower may have at any time against a beneficiary named in a Letter of Credit, any transferee of any Letter of Credit (or any Person for whom any such transferee may be acting), any
Lender or any other Person, whether in connection with this Agreement, any Letter of Credit, the transactions contemplated herein or any unrelated transactions (including any underlying transaction between the Borrower and the beneficiary named in
any Letter of Credit); (y) the validity, sufficiency or genuineness of any document which the Letter of Credit Issuer has determined in good faith complies on its face with the terms of the applicable Letter of Credit, even if such document should
later prove to have been forged, fraudulent, invalid or insufficient in any respect or any statement therein shall have been untrue or inaccurate in any respect; or (z) the surrender or material impairment of any security for the performance or
observance of any of the terms hereof. 
  
 (b) Notwithstanding any
provisions to the contrary in any Reimbursement Agreement, the Borrower agrees to reimburse the Letter of Credit Issuer for amounts which the Letter of Credit Issuer pays under such Letter of Credit no later than the time specified in this
Agreement. If the Borrower does not pay any such Reimbursement Obligations when due, the Borrower shall be deemed to have immediately requested that the Lenders make Revolving Loans that are Base Rate Loans under this Agreement in an aggregate
principal amount equal to 
  

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 such unreimbursed Reimbursement Obligations. The Administrative Agent shall promptly notify the Lenders of such deemed
request and, without the necessity of compliance with the requirements of Sections 2.02 or 2.03, each Lender shall make available to the Administrative Agent its Revolving Loan in the manner prescribed for Base Rate Loans. The proceeds
of such Loans shall be paid over by the Administrative Agent to the Letter of Credit Issuer for the account of the Borrower in satisfaction of such unreimbursed Reimbursement Obligations, which shall thereupon be deemed satisfied by the proceeds of,
and replaced by, such Base Rate Loan. 
  
 (c) If the Letter of
Credit Issuer makes a payment on account of any Letter of Credit and is not concurrently reimbursed therefore by the Borrower and if for any reason a Base Rate Loan may not be made pursuant to subsection 2.15.3(b), then as promptly as practical
during normal banking hours on the date of its receipt of such notice or, if not practicable on such date, not later than noon (Chicago time) on the Business Day immediately succeeding such date of notification, each Lender shall deliver to the
Administrative Agent for the account of the Letter of Credit Issuer, in immediately available funds, the purchase price for such Lender’s interest in such unreimbursed Reimbursement Obligations, which shall be an amount equal to such
Lender’s pro-rata share of such payment. Each Lender shall, upon demand by the Letter of Credit Issuer, pay the Letter of Credit Issuer interest on such Lender’s pro-rata share of such draw from the date of payment by the Letter of Credit
Issuer on account of such Letter of Credit until the date of delivery of such funds to the Letter of Credit Issuer by such Lender at a rate per annum, computed for actual days elapsed based on a 360-day year, equal to the Federal Funds Rate for such
period; provided, that such payments shall be made by the Lenders only in the event and to the extent that the Letter of Credit Issuer is not reimbursed in full by the Borrower for interest on the amount of any draw on the Letters of Credit.

  
 (d) At any time after the Letter of Credit Issuer has made a
payment on account of any Letter of Credit and has received from any other Lender such Lender’s pro-rata share of such payment, such Letter of Credit Issuer shall, forthwith upon its receipt of any reimbursement (in whole or in part) by the
Borrower for such payment, or of any other amount from the Borrower or any other Person in respect of such payment (including, without limitation, any payment of interest or penalty fees and any payment under any collateral account agreement of the
Borrower or any Instrument executed pursuant hereto but excluding any transfer of funds from any other Lender pursuant to subsection 2.15.3(b)), transfer to such other Lender such other Lender’s ratable share of such reimbursement or other
amount; provided, that interest shall accrue for the benefit of such Lender from the time such Letter of Credit Issuer has made a payment on account of any Letter of Credit; provided, further, that in the event that the receipt
by the Letter of Credit Issuer of such reimbursement or other amount is found to have been a transfer in fraud of creditors or a preferential payment under the Bankruptcy Code or is otherwise required to be returned, such Lender shall promptly
return to the Letter of Credit Issuer any portion thereof previously transferred by the Letter of Credit Issuer to such Lender, but without interest to the extent that interest is not payable by the Letter of Credit Issuer in connection therewith.

  
 Section 2.15.4 Procedure for Issuance. Prior to the
issuance of each Letter of Credit, and as a condition of such issuance, the Borrower shall deliver to the Letter of Credit Issuer (with a copy to the Administrative Agent) a Reimbursement Agreement signed by the Borrower, together with such other
documents or items as may be required pursuant to the terms thereof, 
  

 24 

 and the proposed form and content of such Letter of Credit shall be reasonably satisfactory to the Letter of Credit
Issuer. Each Letter of Credit shall be issued no earlier than two (2) Business Days after delivery of the foregoing documents, which delivery may be by the Borrower to the Letter of Credit Issuer by facsimile transmission, telex or other electronic
means followed by delivery of executed originals within five days thereafter. The documents so delivered shall be in compliance with the requirements set forth in subsection 2.15.1(b), and shall specify therein (i) the stated amount of the Letter of
Credit requested, (ii) the effective date of issuance of such requested Letter of Credit, which shall be a Business Day, (iii) the date on which such requested Letter of Credit is to expire, (iv) the entity for whose benefit the requested Letter of
Credit is to be issued, which shall be either Borrower or a Subsidiary, and (v) the aggregate amount of Letter of Credit Obligations which are outstanding and which will be outstanding after giving effect to the requested Letter of Credit issuance.
The delivery of the foregoing documents and information shall constitute an “Issuance Request” for purposes of this Agreement. Subject to the terms and conditions of Section 2.15.1 and provided that the applicable conditions set
forth in Section 3.02 hereof have been satisfied, the Letter of Credit Issuer shall, on the requested date, issue a Letter of Credit on behalf of the Borrower in accordance with the Letter of Credit Issuer’s usual and customary business
practices. In addition, any amendment of an existing Letter of Credit shall be deemed to be an issuance of a new Letter of Credit and shall be subject to the requirements set forth above. The Letter of Credit Issuer shall give the Administrative
Agent prompt written notice of the issuance of any Letter of Credit. 
  
 Section 2.15.5 Nature of the Lenders’ Obligations. 
  
 (a) As between the Borrower and the Lenders, the Borrower assumes all risks of the acts and omissions of, or misuse of the Letters of Credit by, the respective beneficiaries of the Letters of Credit. In furtherance
and not in limitation of the foregoing, the Lenders shall not be responsible for (i) the form, validity, sufficiency, accuracy, genuineness or legal effect of any document submitted by any party in connection with the application for an issuance of
a Letter of Credit, even if it should in fact prove to be in any or all respects invalid, insufficient, inaccurate, fraudulent or forged; (ii) the validity or sufficiency of any instrument transferring or assigning or purporting to transfer or
assign a Letter of Credit or the rights or benefits thereunder or proceeds thereof, in whole or in part, which may prove to be invalid or ineffective for any reason; (iii) the failure of the beneficiary of a Letter of Credit to comply fully with
conditions required to be satisfied by any Person other than the Letter of Credit Issuer in order to draw upon such Letter of Credit (other than a failure to satisfy documentary conditions to drawing where payment of the Letter of Credit despite
such failure would constitute gross negligence or willful misconduct of the Letter of Credit Issuer); (iv) errors, omissions, interruptions or delays in transmission or delivery of any messages, by mail, cable, telegraph, facsimile transmission,
telex or otherwise; (v) the misapplication by the beneficiary of a Letter of Credit of the proceeds of any drawing under such Letter of Credit; or (vi) any consequences arising from causes beyond control of the Letter of Credit Issuer. 

 
 (b) In furtherance and extension and not in limitation of the specific
provisions hereinabove set forth (including in subsection 2.15.3(a)), any action taken or omitted by the Letter of Credit Issuer under or in connection with the Letters of Credit or any related certificates, if taken or omitted in good faith, shall
not put the Administrative Agent or any Lender under any resulting liability to the Borrower or relieve the Borrower of any of its obligations hereunder to the Letter of Credit Issuer or any such Person. 
  

 25 

 Section 2.15.6 Letter of Credit Fees. The Borrower hereby agrees to pay letter of credit fees with
respect to each Letter of Credit from and including the date of issuance thereof until the date such Letter of Credit is fully drawn, canceled or expired, (a) for the account of the Letter of Credit Issuer, an issuance fee equal to 1/8 of 1% of the
initial face amount of such Letter of Credit, payable on the date of issuance, and (b) for the ratable account of the Lenders, a per annum percentage of the aggregate amount from time to time available to be drawn on such Letter of Credit
equal to the LIBOR Margin from time to time in effect, payable quarterly in arrears on the last day of each calendar quarter of each year, and upon the expiration, cancellation or utilization in full of such Letter of Credit. In addition to the
foregoing, the Borrower agrees to pay the Letter of Credit Issuer any other administrative fees customarily charged by it in respect of Letters of Credit issued by it to the extent such administrative fees are previously disclosed to the Borrower by
the Letter of Credit Issuer prior to the issuance of a Letter of Credit. 
  
 Section 2.15.7 Cash Collateralization at Maturity of Loans. On the fifth Business Day prior to the Revolving Credit Termination Date, the Borrower shall deposit with the Administrative Agent an amount in
immediately available funds equal to 105% of the undrawn portion of all Letters of Credit then outstanding, such amount to be held in a separate segregated cash collateral account to secure the Letter of Credit Obligations relating to such undrawn
portion pursuant to documentation in form and substance satisfactory to the Administrative Agent in all respects. Such documentation shall contain, among other things, a representation and warranty that such funds are free of all other Liens and
that the Administrative Agent, for the benefit of itself and the Lenders, has a first perfected security interest therein to secure such Letter of Credit Obligations. 
  
 ARTICLE III 
  
 CONDITIONS 
  
 Section 3.01 Effectiveness. This Agreement shall become effective on the date that each of the following conditions shall have been satisfied (or
waived in accordance with Section 9.05): 
  
 (a) receipt
by the Administrative Agent of counterparts hereof signed in number sufficient for each party by each of the parties hereto (or, in the case of any party as to which an executed counterpart shall not have been received, receipt by the Administrative
Agent in form satisfactory to it of telegraphic, telex or other written confirmation from such party of execution of a counterpart hereof by such party); 
  
 (b) receipt by the Administrative Agent for the account of each Lender of a duly executed Revolving Note and Term Note, dated on or before the Effective
Date, complying with the provisions of Section 2.04; 
  
 (c) receipt by the Administrative Agent of an opinion of Bryan Cave LLP, special counsel for the Borrower, substantially in the form of Exhibit B hereto, and covering such additional matters relating to the transactions contemplated
hereby as the Required Lenders may reasonably request; 
  

 26 

 (d) receipt by the Administrative Agent of all fees payable on or prior to the Effective Date;

  
 (e) receipt by the Administrative Agent of all documents it
may reasonably request relating to the existence of the Borrower and the corporate authority for and the validity of this Agreement and the Notes, all in form and substance satisfactory to the Administrative Agent; 
  
 (f) since December 31, 2003 there has been no event, condition or occurrence
that could have a Material Adverse Effect; and 
  
 (g) the
Existing 364 Day Agreement shall have been fully terminated and all “Obligations” outstanding under and defined therein shall be fully paid 
  
 provided that this Agreement shall not become effective or be binding on any party hereto unless all of the foregoing conditions are satisfied not later than March
7, 2005. The Administrative Agent shall promptly notify the Borrower and the Lenders of the Effective Date, and such notice shall be conclusive and binding on all parties hereto. 
  
 Section 3.02 Borrowings. The obligation of any Lender to make a Loan on the occasion of any Borrowing and the
obligation of the Letter of Credit Issuer to issue any Letter of Credit is subject to the satisfaction of the following conditions: 
  
 (a) in the case of a Revolving Loan or Letter of Credit, the fact that, immediately after making such Revolving Loan or issuing such Letter of Credit, the
sum of the aggregate outstanding principal amount of the Revolving Loans and the aggregate amount of Letter of Credit Obligations will not exceed the aggregate amount of the Revolving Commitments; 
  
 (b) the fact that, immediately before and after making such Loan or issuing
such Letter of Credit, no Default or Event of Default shall have occurred and be continuing; 
  
 (c) the fact that the representations and warranties of the Borrower contained in this Agreement shall be true in all material respects on and as of the date of such Borrowing, provided that the representation
and warranty contained in Section 4.04(b), 4.05 and 4.07 shall apply only to the first borrowing hereunder; 
  
 (d) in the case of a Term Loan, the fact that immediately after making such Term Loan, the aggregate outstanding principal amount of the Term Loans will
not exceed the aggregate amount of the Term Commitments; and 
  
 (e) in the case of the first Term Loan, the Administrative Agent shall have received (i) a true and correct copy of the purchase and sale agreement (including all amendments and other modifications thereto) for the acquisition of JRH
Biosciences in form and substance reasonably satisfactory to the Administrative Agent, (ii) revised schedules to this 
  

 27 

 Agreement, in form and substance reasonably satisfactory to the Administrative Agent, reflecting any changes required to
make the representations and warranties hereunder true and correct as of the date of such acquisition, and (iii) a certificate of the Senior Financial Officer stating that immediately after giving effect to such acquisition no Default or Event of
Default will have occurred and be continuing. 
  
 The acceptance
of the proceeds of each Loan hereunder and each request to issue a Letter of Credit pursuant hereto shall be deemed to be a representation and warranty by the Borrower on the date of such Loan as to the facts specified in clauses (a), (b), (c), (d)
and (e) of this Section. 
  
 ARTICLE IV 
  
 REPRESENTATIONS AND WARRANTIES 
  
 The Borrower represents and warrants that: 
  
 Section 4.01 Corporate Existence and Power. The Borrower (i) is a
corporation duly incorporated, validly existing and in good standing under the laws of Delaware, (ii) has all corporate powers required to carry on its business as now conducted and (iii) has all governmental licenses, authorizations, consents and
approvals required to carry on its business as now conducted, except where the failure to have such governmental licenses, authorizations, consents or approvals could not reasonably be expected to have a Material Adverse Effect on the business,
consolidated financial position or results of operations of the Borrower and its Subsidiaries considered as a whole or a Material Adverse Effect. 
  
 Section 4.02 Corporate and Governmental Authorization; No Contravention. The execution, delivery and performance by the Borrower of this Agreement
and the Notes are within the Borrower’s corporate powers, have been duly authorized by all necessary corporate action, require no action by or in respect of, or filing with, any governmental body, agency or official and do not contravene, or
constitute a default under, any provision of applicable law or regulation or of the articles of incorporation or by-laws of the Borrower or of any judgment, injunction, order or decree, or of any material agreement or other material instrument
binding upon the Borrower or result in the creation or imposition of any Lien on any material asset of the Borrower or any of its Subsidiaries. 
  
 Section 4.03 Binding Effect. This Agreement constitutes a valid and binding agreement of the Borrower, and the Notes, when executed and delivered
in accordance with this Agreement, will constitute valid and binding obligations of the Borrower. 
  
 Section 4.04 Financial Information. 
  
 (a) The audited consolidated balance sheets of the Borrower and its Subsidiaries as of December 31, 2003, and the related consolidated statements of
income, cash flows and shareholders’ equity for the Fiscal Year then ended, set forth in the Borrower’s annual report on Form 10-K, a copy of which annual report has been delivered to each of the Lenders, fairly present, in conformity with
generally accepted accounting principles, the consolidated financial position of the Borrower and its Subsidiaries as of such date and their consolidated results of operations and cash flows for such fiscal year. 
  

 28 

 (b) Since December 31, 2003, there has been no event, condition or occurrence that could have a Material
Adverse Effect. 
  
 Section 4.05 Litigation. Except as
described on Schedule 4.05, there is no action, suit or proceeding pending against, or to the knowledge of the Borrower, threatened against or affecting, the Borrower or any of its Subsidiaries before any court or arbitrator or any
governmental body, agency or official which, if adversely decided, could reasonably be expected to have a Material Adverse Effect. 
  
 Section 4.06 Compliance with ERISA. Each member of the ERISA Group has fulfilled its obligations under the minimum funding standards of ERISA and
the Internal Revenue Code with respect to each Plan and is in compliance in all material respects with the presently applicable provisions of ERISA and the Internal Revenue Code with respect to each Plan. Except as described on Schedule 4.06,
no member of the ERISA Group has (i) sought a waiver of the minimum funding standard under Section 412 of the Internal Revenue Code in respect of any Plan, (ii) failed to make any contribution or payment to any Plan or Multiemployer Plan or in
respect of any Benefit Arrangement, or made any amendment to any Plan or Benefit Arrangement, which has resulted or could result in the imposition of a Lien or the posting of a bond or other security under ERISA or the Internal Revenue Code or (iii)
incurred any liability under Title IV of ERISA other than a liability to the PBGC for premiums under Section 4007 of ERISA. 
  
 Section 4.07 Environmental Matters. In the ordinary course of its business, the Borrower conducts a review at such times as it deems prudent of the
effect of Environmental Laws on the properties of the Borrower and its Subsidiaries, in the course of which it identifies and evaluates associated liabilities and costs (including, without limitation, any capital or operating expenditures required
for clean-up or closure of properties presently or previously owned, any capital or operating expenditures required to achieve or maintain compliance with environmental protection standards imposed by law or as a condition of any license, permit or
contract, any related constraints on operating activities, including any periodic or permanent shutdown of any facility or reduction in the level of or change in the nature of operations conducted thereat and any actual or potential liabilities to
third parties, including employees, and any related costs and expenses). On the basis of this review, the Borrower has reasonably concluded that Environmental Laws are unlikely to have a Material Adverse Effect. 
  
 Section 4.08 Taxes. The Borrower and its Subsidiaries have filed all
United States Federal income tax returns and all other material income tax returns which are required to be filed by them, taking into account any filing extensions for any such returns, and have paid all taxes due pursuant to such returns or
pursuant to any assessment received by the Borrower or any of its Subsidiaries except such taxes or assessments, if any, as are being contested in good faith by appropriate proceedings for which adequate reserves have been established as required by
generally accepted accounting principles. The charges, accruals and reserves on the books of the Borrower and its Subsidiaries in respect of taxes or other governmental charges are, in the opinion of the Borrower, adequate. 
  

 29 

 Section 4.09 Subsidiaries. Schedule 4.09 hereto contains an accurate list of all of the
Borrower’s Subsidiaries, setting forth their respective jurisdictions of incorporation or formation and the percentage of their capital stock or other ownership interests owned by the Borrower or other Subsidiaries. Each of the Borrower’s
corporate Subsidiaries that is material to the business or operations of the Borrower and its Subsidiaries, considered as a whole, is a corporation duly incorporated, validly existing and in good standing under the laws of its jurisdiction of
incorporation, and has all corporate powers and all governmental licenses, authorizations, consents and approvals required to carry on its business as now conducted, except where the failure to have such governmental licenses, authorizations,
consents and approvals could not reasonably be expected to have a Material Adverse Effect. 
  
 Section 4.10 Full Disclosure. All information heretofore furnished in writing by the Borrower to the Administrative Agent or any Lender for purposes of or in connection with this Agreement or any transaction
contemplated hereby is, and all such information hereafter furnished in writing by the Borrower to the Administrative Agent or any Lender will be, true and accurate in all material respects on the date as of which such information is stated or
certified. The Borrower has disclosed to the Lenders in writing any and all facts which could reasonably be expected to have a Material Adverse Effect. 
  
 Section 4.11 Regulated Entities. Neither the Borrower nor any of its Subsidiaries is an “investment company” registered or required to be
registered under the Investment Company Act of 1940, as amended, or controlled by such a company. Neither the Borrower nor any of its Subsidiaries is a “holding company” or a “subsidiary company” of a “holding company”
or an “affiliate” of a “holding company” within the meaning of the Public Utility Holding Company Act of 1935, as amended. 
  
 Section 4.12 Compliance With Laws. The Borrower and its Subsidiaries have complied with all applicable statutes, rules, regulations, orders and
restrictions of any domestic or foreign government or any instrumentality or agency thereof, having jurisdiction over the conduct of their respective businesses or the ownership of their respective Property, except where the failure to so comply
could not reasonably be expected to have a Material Adverse Effect. Neither the Borrower nor any Subsidiary has received any notice to the effect that its operations are not in material compliance with any of the requirements of applicable federal,
state and local environmental, health and safety statutes and regulations or the subject of any federal or state investigation evaluating whether any remedial action is needed to respond to a release of any toxic or hazardous waste or substance into
the environment, which non-compliance or remedial action could reasonably be expected to have a Material Adverse Effect. 
  
 Section 4.13 Default or Event of Default. On the date hereof, no Default or Event of Default has occurred and is continuing. 
  
 Section 4.14 Liens. As of the date hereof neither the Borrower nor any
of its Subsidiaries has incurred any Lien other than those permitted pursuant to Section 5.07. 
  
 Section 4.15 Material Agreements. Neither the Borrower nor any Subsidiary is a party to any agreement or instrument or subject to any charter or
other corporate restriction which 
  

 30 

 could reasonably be expected to have a Material Adverse Effect. Neither the Borrower nor any Subsidiary is in default in
the performance, observance or fulfillment of any of the obligations, covenants or conditions contained in any agreement to which it is a party, which default could reasonably be expected to have a Material Adverse Effect. Neither the Borrower nor
any Subsidiary is in default in the performance, observance or fulfillment of any of the obligations, covenants or conditions contained in any agreement or instrument evidencing or governing Debt. 
  
 ARTICLE V 
  
 COVENANTS 
  
 The Borrower agrees that, so long as any Commitment or Letter of Credit remains outstanding hereunder or any amount payable under any of the Loan
Documents remains unpaid: 
  
 Section 5.01 Information.
The Borrower will deliver to each of the Lenders: 
  
 (a) as soon
as available, but in any event by the earlier of (x) the date that is 105 days after the end of each Fiscal Year of the Borrower and (y) 15 days after the date the Borrower is required to file its Form 10-K with the SEC (without giving effect to any
extension of such due date, whether obtained by filing the notification permitted by Rule 12b-25 or any successor provision thereto or otherwise), audited consolidated balance sheets of the Borrower and its Subsidiaries as of the end of such Fiscal
Year and the related consolidated statements of income, cash flows and shareholders’ equity for such Fiscal Year, setting forth in each case in comparative form the figures for the previous Fiscal Year, with an unqualified opinion of
independent public accountants of nationally recognized standing in a manner acceptable to the Securities and Exchange Commission; 
  
 (b) other than with respect to the last Fiscal Quarter of each Fiscal Year, as soon as available, but in any event by the earlier of the date that is 60
days after the end of each Fiscal Quarter of the Borrower and not later than 15 days after the date the Borrower is required to file its Form 10-Q with the SEC (without giving effect to any extension of such due date, whether obtained by filing the
notification permitted by Rule 12b-25 or any successor provision thereto or otherwise), (i) consolidated balance sheets of the Borrower and its Subsidiaries as of the end of such Fiscal Quarter, (ii) the related consolidated statements of income for
such Fiscal Quarter and for the portion of the Fiscal Year ended at the end of such Fiscal Quarter, and (iii) cash flows for the portion of the Fiscal Year ended at the end of such Fiscal Quarter, setting forth in each case in comparative form the
figures for the equivalent period and the previous year, all certified (subject to normal year-end adjustments) as to fairness of presentation, generally accepted accounting principles and consistency by the Senior Financial Officer of the Borrower;
provided, however, that delivery to the Lenders within the time period specified above of copies of the Borrower’s Quarterly Report on Form 10-Q prepared in compliance with the requirements therefor, and as filed with the
Securities Exchange Commission, shall be deemed to satisfy the requirements of this Section 5.01(b); 
  
 (c) simultaneously with the delivery of each set of financial statements referred to in clauses (a) and (b) above, a certificate (“Compliance
Certificate”) of the Senior Financial Officer of the Borrower substantially in the form of Exhibit D hereto (i) setting forth in 
  

 31 

 reasonable detail the calculations required to establish whether the Borrower was in compliance with the requirements of
Sections 5.05, 5.06 and 5.11 on the date of such financial statements and the application of the Pricing Schedule, and (ii) stating whether any Default or Event of Default exists on the date of such certificate and, if any
Default or Event of Default then exists, setting forth the details thereof and the action which the Borrower is taking or proposes to take with respect thereto; 
  

(d) within five days after the Borrower obtains knowledge of any Default or Event of Default, if such Default or Event of Default is then continuing, a
certificate of the Senior Financial Officer setting forth the details thereof and the action which the Borrower is taking or proposes to take with respect thereto; 
  
 (e) within fifteen days after the mailing thereof to the shareholders of the Borrower generally, copies of all financial
statements, reports and proxy statements so mailed; 
  
 (f) within
fifteen days after the filing thereof, copies of all registration statements (other than the exhibits thereto and any registration statements on Form S-8 or its equivalent) and reports on Forms 10-K, 10-Q and 8-K (or their equivalents) which the
Borrower shall have filed with the Securities and Exchange Commission; 
  
 (g) if and when any member of the ERISA Group (i) gives or is required to give notice to the PBGC of any “reportable event” (as defined in Section 4043 of ERISA) with respect to any Plan which would constitute grounds for a
termination of such Plan under Title IV of ERISA, or knows that the plan administrator of any Plan has given or is required to give notice of any such reportable event, a copy of the notice of such reportable event given or required to be given to
the PBGC; (ii) receives notice of complete or partial withdrawal liability under Title IV of ERISA or notice that any Multiemployer Plan is in reorganization, is insolvent or has been terminated, a copy of such notice; (iii) receives notice from the
PBGC under Title IV of ERISA of an intent to terminate, impose liability (other than for premiums under Section 4007 of ERISA) in respect of, or appoint a trustee to administer any Plan, a copy of such notice; (iv) applies for a waiver of the
minimum funding standard under Section 412 of the Internal Revenue Code, a copy of such application; (v) gives notice of intent to terminate any Plan under Section 4041(c) of ERISA, a copy of such notice and other information filed with the PBGC;
(vi) gives notice of withdrawal from any Plan pursuant to Section 4063 of ERISA, a copy of such notice; or (vii) fails to make any payment or contribution to any Plan or Multiemployer Plan or makes any amendment to any Plan which has resulted or
could result in the imposition of a Lien or the posting of a bond or other security, a certificate of the Senior Financial Officer of the Borrower setting forth details as to such occurrence and action, if any, which the Borrower or applicable
member of the ERISA Group is required or proposes to take; 
  
 (h)
promptly after any Senior Financial Officer of the Borrower obtains knowledge of any change by Moody’s or S&P of the rating of the Borrower’s outstanding senior unsecured long-term debt securities, notice of such change; and

  
 (i) from time to time such additional information regarding
the financial position or business of the Borrower and its Subsidiaries as the Administrative Agent, at the request of any Lender, may reasonably request; provided, however, that if such additional 
  

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 information is non-public proprietary and confidential information of the Borrower or any Subsidiary, the Borrower may
require a confidentiality agreement reasonably acceptable to the Borrower from such Lender prior to providing such information to such Lender. 
  
 Section 5.02 Maintenance of Property; Insurances. 
  
 (a) The Borrower will cause all property used or useful in the conduct of its business or the business of any Subsidiary to be maintained and kept in good
condition, repair and working order and supplied with all necessary equipment and will cause to be made all necessary repairs, renewals, replacements, betterments and improvements thereof, all as in the judgment of the Borrower may be necessary so
that the business carried on in connection therewith may be properly and advantageously conducted at all times; provided, however, that nothing in this Section shall prevent the Borrower from (i) discontinuing the operation or
maintenance of any of such properties if such discontinuance is, in the judgment of the Borrower, desirable in the conduct of its business or the business of any Subsidiary and not disadvantageous in any material respect to the Lenders, or (ii)
consummating a Permitted Disposition. 
  
 (b) The Borrower will,
and will cause each of its Subsidiaries to, maintain (either in the name of the Borrower or in such Subsidiary’s own name) insurance on such of their respective properties in such amounts and against such risks (and with such risk retention) as
the Borrower, in the exercise of its reasonable judgment, deems necessary or appropriate. 
  
 Section 5.03 Conduct of Business and Maintenance of Existence. The Borrower will, and will cause each Subsidiary to, substantially continue to engage in the chemicals business or businesses ancillary thereto,
and will preserve, renew and keep in full force and effect, and will cause each Subsidiary to preserve, renew and keep in full force and effect their respective corporate existence and their respective rights, privileges and franchises necessary or
desirable in the normal conduct of business, provided, however, that the Borrower shall not be required to preserve any such right or franchise if the Board of Directors shall determine that the preservation thereof is no longer
desirable in the conduct of the business of the Borrower and that the loss thereof is not disadvantageous in any material respect to the Lenders; and provided further, that nothing in this Section shall prevent the Borrower from
consummating a Permitted Disposition. 
  
 Section 5.04
Compliance with Laws. The Borrower will comply, and cause each Subsidiary to comply, in all respects with all applicable laws, ordinances, rules, regulations, and requirements of governmental authorities (including, without limitation,
Environmental Laws and ERISA and the rules and regulations thereunder) except where the necessity of compliance therewith is contested in good faith by appropriate proceedings and except where the failure to comply could not reasonably be expected
to have a Material Adverse Effect. 
  
 Section 5.05
Capitalization Ratio. The Capitalization Ratio will not be, at any time, more than 0.55 to 1.0. 
  
 Section 5.06 Consolidated Net Worth. The Borrower will not, at any time, permit Consolidated Net Worth to be less than $750,000,000.

  

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 Section 5.07 Negative Pledge. Neither the Borrower nor any Subsidiary shall incur or suffer to
exist any Lien, except: 
  
 (a) Liens to secure Debt
existing on the Effective Date and described on Schedule 5.07 hereto; 
  
 (b) Liens to secure Debt incurred to extend, renew, refinance or refund (or successive extensions, renewals, refinancing or refundings), in whole or in part, Debt secured by any Lien referred to in the foregoing
clause (a) as long as such Lien does not extend to any other property and the original amount of the Debt so secured is not increased; 
  
 (c) Liens arising in the ordinary course of its business which (i) do not secure Debt, (ii) do not secure any contingent or fixed obligation in an amount
exceeding $10,000,000 and (iii) do not in the aggregate materially detract from the value of its assets or materially impair the use thereof in the operation of its business; and 
  
 (d) Liens not otherwise permitted by clauses (a) and (b) of this Section 5.07 securing Debt incurred after the date
hereof if, after giving effect thereto, the aggregate amount outstanding of Debt secured by Liens under clauses (a), (b) and (d) of this Section 5.07, together with the aggregate amount outstanding of unsecured Debt of the Subsidiaries, does
not exceed at any time 20% of Consolidated Net Worth. 
  
 Section
5.08 Consolidations, Mergers and Sales of Assets. (a) Neither the Borrower nor any Subsidiary will consolidate or merge with or into any other Person unless (A) the Borrower is the corporation surviving such merger or, in the case of any
Subsidiary consolidating or merging with a Person other than the Borrower, the surviving entity is a Subsidiary, and (B) immediately after giving effect to such merger, no Default or Event of Default shall have occurred and be continuing.

  
 (b) Other than sales of inventory and worn or obsolete
equipment in the ordinary course of business, the Borrower will not, and will not permit any Subsidiary to, sell, lease (as lessor) or otherwise transfer, directly or indirectly, any property, unless the aggregate book value of such property as
shown by the accounting books and records of the Borrower, together with the aggregate book value of all other property as shown by the accounting books and records of the Borrower (including the aggregate book value of all property which is sold by
the Borrower or any Subsidiary in Sale and Leaseback Transactions less the Capitalized Lease Obligations arising therefrom) sold, leased or otherwise transferred pursuant to this subsection (b) after the Effective Date, does not exceed 20% of total
consolidated assets of the Borrower and its Subsidiaries determined as of the most recently-ended Fiscal Quarter from a consolidated balance sheet of the Borrower prepared in accordance with generally accepted accounting principles. 
  
 (c) The Borrower will not, and will not permit any Subsidiary to, sell,
transfer or otherwise dispose of the capital stock or other equity interests of its respective Subsidiaries (other than intra-company transfers among Subsidiaries, in the ordinary course of business for tax purposes, provided such transactions would
not have a Material Adverse Effect) (a “Permitted Disposition”) unless the Borrower shall have delivered to the Administrative Agent 
  

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 on the date of the consummation of such Permitted Disposition an officer’s certificate executed by an authorized
officer of the Borrower, which certificate shall (x) certify that no Default or Event of Default shall have occurred and be continuing before and after giving effect to such Permitted Disposition and (y) demonstrate that at the time of such
Permitted Disposition the covenants contained in Sections 5.05 and 5.06 would not have been breached on a pro forma basis for the most recent four consecutive Fiscal Quarters ending on or prior to the date such Permitted Disposition
was consummated as if such Permitted Disposition had occurred on the last day of such period. 
  
 Section 5.09 Transactions with Affiliates. The Borrower will not, and will not permit any Subsidiary to, directly or indirectly, enter into any material transaction with any Affiliate (other than a transaction
between the Borrower and any Subsidiary or a transaction between Subsidiaries) which transaction is not on terms and conditions at least as favorable to the Borrower or such Subsidiary as the terms and conditions which would apply in a similar
transaction with a Person not an Affiliate (an “Arm’s-Length Transaction”). Any material transaction with any Affiliate shall be deemed to be an Arm’s-Length Transaction if approved by (a) a majority of the Borrower’s
directors who are unaffiliated with such Affiliate or (b) a majority of the members of any committee of the Board of Directors of the Borrower who are unaffiliated with such Affiliate. 
  
 Section 5.10 Use of Proceeds. The proceeds of (i) the Revolving Loans and Letters of Credit shall be used for general
corporate and working capital purposes, including payment of any of the Borrower’s commercial paper, and (ii) the Term Loans shall be used to fund the purchase price for the acquisition of JRH Biosciences, including any post-closing working
capital adjustment obligations of Borrower in connection therewith. The proceeds of the Loans made, and the Letters of Credit issued, will not be used by the Borrower, directly or indirectly, in the purchasing or carrying of “margin stock”
within the meaning of Regulation U or otherwise in any manner in contravention of Regulation U. Not more than 25% of the assets of the Borrower at any time shall be comprised of margin stock (other than the capital stock of the Borrower which will
be immediately retired by the Borrower or held as treasury stock). 
  
 Section 5.11 Limitation on Debt. The Borrower will not, nor will it permit any of its Subsidiaries to, incur or at any time be liable with respect to any Debt except (a) Debt outstanding on the date hereof, (b) the Borrower may incur
Debt hereafter if, after giving effect thereto, the Capitalization Ratio is not more than 0.55 to 1.00, (c) Debt of any Subsidiary incurred hereafter and owing to the Borrower or any Subsidiary, and (d) the Subsidiaries may incur Debt hereafter not
otherwise permitted by clause (a) of this Section 5.11 if, after giving effect thereto, the aggregate amount outstanding of Debt under clauses (a) and (d) of this Section 5.11, together with the aggregate amount outstanding of Debt of
the Borrower and its Subsidiaries secured by Liens, does not exceed at any time 20% of Consolidated Net Worth. 
  
 Section 5.12 Limitation on Certain Covenants and Restrictions. The Borrower will not, and will not permit any Subsidiary to, enter into or permit
to exist any agreement with any Person which prohibits or limits the ability of any Subsidiary to (a) declare or pay any dividend or (b) make any loan to or Investment in the Borrower or any other Subsidiary; provided that this clause (b)
shall not prohibit agreements between the Borrower or any Subsidiary and any Person which require that transactions with any Affiliate (i) be on an “arm’s-length” basis, (ii) be approved by the disinterested directors of the Board of
Directors, or (iii) be subject to any substantive or procedural requirements substantially similar to clause (i) or (ii) above. 
  

 35 

 Section 5.13 Taxes. The Borrower will, and will cause each of its Subsidiaries to, pay and
discharge as the same shall become due and payable, all their respective tax liabilities, assessments and governmental charges or levies upon it or its properties or assets, unless the same are being contested in good faith by appropriate
proceedings and adequate reserves in accordance with generally accepted accounting principles are being maintained by the Borrower or such Subsidiary. 
  
 ARTICLE VI 
  
 DEFAULTS 
  
 Section 6.01 Events of Default. If one or more of the following events (“Events of Default”) shall have occurred and be continuing: 
  
 (a) the Borrower shall fail to pay when due any principal of any Loan or Letter of Credit Obligation, or shall fail to pay
within five Business Days of the due date thereof any interest on any Loan, any fees or any other amount payable hereunder; 
  
 (b) the Borrower shall fail to observe or perform any covenant contained in Section 2.15.7 (Cash Collateralization at Maturity of Loans),
Sections 5.01(a), (b), (d) (Information), 5.05 (Capitalization Ratio), 5.06 (Consolidated Net Worth), 5.07 (Negative Pledge), 5.08 (Consolidations, Mergers and Sale of Assets), 5.10 (Use of
Proceeds), 5.11 (Limitation on Debt) or 5.12 (Limitation on Certain Covenants and Restrictions) and such failure shall continue for a period of five Business Days; 
  
 (c) the Borrower shall fail to observe or perform any covenant or agreement contained in this Agreement or any other Loan
Document (other than those covered by clause (a) or (b) above) and such failure shall continue for a period of thirty (30) days; 
  
 (d) any representation, warranty, certification or statement made by the Borrower in this Agreement or any other Loan Document or in any certificate,
financial statement or other written document delivered pursuant to this Agreement or any other Loan Document shall prove to have been incorrect in any material respect when made (or deemed made); 
  
 (e) the Borrower or any Subsidiary shall fail to make payment of any Material
Debt when due or within any applicable grace period; 
  
 (f) any
event or condition shall occur which enables the holder of Material Debt or any Person acting on such holder’s behalf to accelerate the maturity thereof (including, without limitation, any required mandatory prepayment or “put” of
such Debt to the Borrower or any Subsidiary) whether or not acceleration of such Debt results; 
  
 (g) the Borrower or any Subsidiary (other than AAPL Joint Venture or Genosys Biotin Partners, so long as either company’s total assets, on a book or market value 
  

 36 

 basis do not at the time exceed $5 million) shall commence a voluntary case or other proceeding seeking liquidation,
reorganization or other relief with respect to itself or its debts under any bankruptcy, insolvency or other similar law now or hereafter in effect or seeking the appointment of a trustee, receiver, liquidator, custodian or other similar official of
it or any substantial part of its property, or shall consent to any such relief or to the appointment of or taking possession by any such official in an involuntary case or other proceeding commenced against it, or shall make a general assignment
for the benefit of creditors, or shall take any corporate action to authorize any of the foregoing; 
  
 (h) an involuntary case or other proceeding shall be commenced against the Borrower or any Subsidiary (other than AAPL Joint Venture or Genosys Biotin
Partners, so long as either company’s total assets, on a book or market value basis do not at the time exceed $5 million) seeking liquidation, reorganization or other relief with respect to it or its debts under any bankruptcy, insolvency or
other similar law now or hereafter in effect or seeking the appointment of a trustee, receiver, liquidator, custodian or other similar official of it or any substantial part of its property, and such involuntary case or other proceeding shall remain
undismissed and unstayed for a period of 60 days; or an order for relief shall be entered against the Borrower or any Subsidiary under the federal bankruptcy laws as now or hereafter in effect; 
  
 (i) any member of the ERISA Group shall fail to pay when due an amount or
amounts aggregating in excess of $25,000,000 which it shall have become liable to pay under Title IV of ERISA; or notice of intent to terminate a Material Plan shall be filed under Title IV of ERISA by any member of the ERISA Group, any plan
administrator or any combination of the foregoing; or the PBGC shall institute proceedings under Title IV of ERISA to terminate, to impose liability (other than for premiums under Section 4007 of ERISA) in respect of, or to cause a trustee to be
appointed to administer any Material Plan; or a condition shall exist by reason of which the PBGC would be entitled to obtain a decree adjudicating that any Material Plan must be terminated; or there shall occur a complete or partial withdrawal
from, or a default, within the meaning of Section 4219(c)(5) of ERISA, with respect to, one or more Multiemployer Plans which could cause one or more members of the ERISA Group to incur a current payment obligation in excess of $25,000,000;

  
 (j) an uninsured judgment or judgments for the payment of
money aggregating in excess of $25,000,000 are rendered against the Borrower and its Subsidiaries and which judgments are not, within 60 days after entry thereof, bonded, discharged or stayed pending appeal, or are not discharged within 60 days
after the expiration of such stay; 
  
 (k) any person or group of
persons (within the meaning of Section 13 or 14 of the Securities Exchange Act of 1934, as amended) shall have acquired beneficial ownership (within the meaning of Rule 13d-3 promulgated by the Securities and Exchange Commission under said Act) of
30% or more in voting power of the outstanding Voting Stock of the Borrower; or, during any period of 24 consecutive calendar months, a majority of the board of directors of the Borrower does not consist of individuals who were (i) directors of the
Borrower on the first day of such period, (ii) directors who were selected or whose nomination for election was approved by a vote of at least a majority of the directors then still in office referred to in clause (i) above, or (iii) directors who
were selected or whose nomination for election was approved by a vote of at least a majority of the board consisting of directors still in office described in clauses (i) and (ii) above or this clause (iii); or 
  

 37 

 (l) the Borrower shall repudiate, or shall challenge the validity or enforceability of its obligations
under the Loan Documents or for any reason the Loan Documents shall cease to be in full force and effect; 
  
 then, and in every such event, the Administrative Agent shall (i) if requested by the Required Lenders, by notice to the Borrower terminate the Commitments and they shall thereupon terminate and (ii) if requested by
the Required Lenders, by notice to the Borrower declare the Notes and all Obligations (together with accrued interest thereon) and any other amount payable hereunder to be, and the Notes and all Obligations and any other amount payable hereunder
shall thereupon become, immediately due and payable without presentment, demand, protest or other notice of any kind, all of which are hereby waived by the Borrower; provided that in the case of any of the Events of Default specified in
clause (g) or (h) above with respect to the Borrower, without any notice to the Borrower or any other act by the Administrative Agent or the Lenders, the Commitments shall thereupon terminate and the Notes and all Obligations (together with accrued
interest thereon) shall become immediately due and payable without presentment, demand, protest or other notice of any kind, all of which are hereby waived by the Borrower. Upon the occurrence of any of the foregoing, the Borrower shall immediately
deposit with the Administrative Agent an amount in immediately available funds equal to 105% of the undrawn portion of all Letters of Credit then outstanding, such amount to be held in a separate segregated cash collateral account to secure the
Letter of Credit Obligations relating to such undrawn portion. 
  
 Section 6.02 Notice of Default. The Administrative Agent shall give notice to the Borrower under Section 6.01(c) promptly upon being requested to do so by any Lender and shall thereupon notify all the Lenders thereof.

  
 ARTICLE VII 
  
 THE ADMINISTRATIVE AGENT AND LETTER OF CREDIT ISSUER 
  
 Section 7.01 Appointment. The Lenders hereby appoint the
Administrative Agent to act as specified herein and in the Loan Documents. Each Lender hereby irrevocably authorizes and each holder of any Note by the acceptance of such Note shall be deemed to irrevocably authorize the Administrative Agent to take
such action on its behalf under the provisions hereof, the Loan Documents (including, without limitation, to give notices and take such actions on behalf of the Required Lenders as are consented to in writing by the Required Lenders, or all Lenders
to the extent required by the terms of this Agreement) and any other instruments, documents and agreements referred to herein or therein and to exercise such powers hereunder and thereunder as are specifically delegated to the Administrative Agent
by the terms hereof and thereof and such other powers as are reasonably incidental thereto. The Administrative Agent may perform any of its duties hereunder and under the Loan Documents, by or through its officers, directors, Administrative Agents,
employees or affiliates. 
  
 Section 7.02 Nature of Duties.
No Administrative Agent-Related Person shall have duties or responsibilities except those expressly set forth in this Agreement. The duties of the 
  

 38 

 Administrative Agent shall be mechanical and administrative in nature. EACH LENDER HEREBY ACKNOWLEDGES AND AGREES THAT
THE ADMINISTRATIVE AGENT SHALL NOT HAVE, BY REASON OF THIS AGREEMENT OR ANY LOAN DOCUMENTS, A FIDUCIARY RELATIONSHIP TO OR IN RESPECT OF ANY LENDER. Nothing in this Agreement or in any Loan Document, expressed or implied, is intended to or shall
be so construed as to impose upon any Administrative Agent-Related Person any obligations in respect of the Agreement or any Loan Document except as expressly set forth herein or therein. Each Lender shall make its own independent investigation of
the financial condition and affairs of the Borrower in connection with the making and the continuance of the Loans hereunder and shall make its own appraisal of the creditworthiness of the Borrower, and except to the extent expressly set forth in
this Agreement or any other Loan Documents, no Administrative Agent-Related Person shall have any duty or responsibility, either initially or on a continuing basis, to provide any Lender with any credit or other information with respect thereto,
whether coming into its possession before making of the Loans or at any time or times thereafter. The Administrative Agent will promptly notify each Lender at any time that the Required Lenders have instructed it to act or refrain from acting
pursuant to Article VI. 
  
 Section 7.03 Exculpation
Rights, Etc. Neither the Administrative Agent nor any of its officers, directors, Administrative Agents, employees, affiliates or any Administrative Agent-Related Person shall be liable for any action taken or omitted by them hereunder or under
any Loan Document, or in connection herewith or therewith, unless caused by its or their gross negligence or willful misconduct. No Administrative Agent-Related Person shall be responsible to any Lender for any recitals, statements, representations
or warranties herein or for the execution, effectiveness, genuineness, validity, enforceability, collectibility, or sufficiency of this Agreement or any Loan Document or any other document or the financial condition of the Borrower. No
Administrative Agent-Related Person shall be required to make any inquiry concerning either the performance or observance of any of the terms, provisions or conditions of this Agreement or any Loan Document or any other document or the financial
condition of the Borrower, or the existence or possible existence of any Default or Event of Default unless requested to do so by the Required Lenders. The Administrative Agent may at any time request instructions from the Lenders with respect to
any actions or approvals (including the failure to act or approve) which by the terms of this Agreement or the Loan Documents, the Administrative Agent is permitted or required to take or to grant, and if such instructions are requested, the
Administrative Agent shall be absolutely entitled to refrain from taking any action or to withhold any approval and shall not be under any liability whatsoever to any person for refraining from any action or withholding any approval under this
Agreement or any Loan Document until it shall have received such instructions from the Required Lenders. Without limiting the foregoing, no Lender shall have any right of action whatsoever against any Administrative Agent-Related Person as a result
of such Administrative Agent-Related Person acting, approving or refraining from acting or approving under any of the Loan Documents in accordance with the instructions of the Required Lenders or, to the extent required by Section 9.05, all
of the Lenders. 
  
 Section 7.04 Reliance. The
Administrative Agent shall be entitled to rely, and shall be fully protected in relying, upon any notice, writing, resolution notice, statement, certificate, order or other document or any telephone, telex, teletype or telecopier message believed by
it to be genuine and correct and to have been signed, sent or made by the proper Person, and, with respect to all matters pertaining herein or to any Loan Document and its duties hereunder to thereunder, upon advice of counsel selected by the
Administrative Agent. 
  

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 Section 7.05 Indemnification. To the extent any Administrative Agent-Related Person is not
reimbursed and indemnified by the Borrower, the Lenders will reimburse and indemnify each Administrative Agent-Related Person for and against any and all liabilities, obligations, losses, damages, claims, penalties, actions, judgments, suits, costs,
expenses or disbursements of any kind or nature whatsoever which may be imposed on, incurred by, or asserted against any Administrative Agent-Related Person in any way relating to or arising out of this Agreement or any Loan Document or any action
taken or omitted by any Administrative Agent-Related Person under this Agreement or any Loan Document, in its capacity as Administrative Agent (and not as a Lender), in proportion to each Lender’s Commitment Percentage; provided,
however, that no Lender shall be liable for any portion of such liabilities, obligations, losses, damages, claims, penalties, actions, judgments, suits, costs, expenses or disbursements resulting from the Administrative Agent’s gross
negligence or willful misconduct. The obligations of the Lenders under this Section 7.05 shall survive the payment in full of the Notes and the termination of this Agreement. 
  
 Section 7.06 Administrative Agent In Its Individual Capacity. With respect to its Loans and Commitments (and its
Revolving Commitment Percentage and Term Commitment Percentage with respect thereto), the Administrative Agent shall have and may exercise the same rights and powers hereunder and is subject to the same obligations and liabilities as and, to the
extent set forth herein, for any other Lender or holder of obligations hereunder. The terms “Lenders”, “holder of obligations” or “Required Lenders” or any similar term shall, unless the context clearly otherwise
indicates, include the Administrative Agent in its individual capacity as a Lender, one of the Required Lenders or a holder of obligations hereunder. The Administrative Agent may accept deposits from, lend money to, and generally engage in any kind
of banking, trust or other business with the Borrower or any Subsidiary or Affiliate of the Borrower as if it were not acting as the Administrative Agent hereunder or under the Loan Documents, including, without limitation, the acceptance of fees or
other consideration for services without having to account for the same to any of the Lenders. 
  
 Section 7.07 Notice of Default. The Administrative Agent shall not be deemed to have knowledge or notice of the occurrence of any Default or Event of Default hereunder unless the Administrative Agent has
received written notice from a Lender or the Borrower referring to this Agreement describing such Default or Event of Default and stating that such notice is a “notice of default.” In the event that the Administrative Agent receives such a
notice, the Administrative Agent shall give prompt notice thereof to the Lenders. 
  
 Section 7.08 Holders of Obligations. The Administrative Agent may deem and treat the payee of any obligation hereunder as reflected on the books and records of the Administrative Agent as the owner thereof for
all purposes hereof unless and until a written notice of the assignment or transfer thereof shall have been filed with the Administrative Agent pursuant to Section 9.06(c). Any request, authority or consent of any Person who, at the time of
making such request or giving such authority or consent, is the holder of any obligation hereunder shall be conclusive and binding on any subsequent holder, transferee or assignee of such obligation or of any obligation or obligations granted in
exchange therefor. 
  

 40 

 Section 7.09 Resignation by the Administrative Agent. 
  
 (a) The Administrative Agent may resign from the performance of all its
functions and duties hereunder at any time by giving fifteen (15) Business Days’ prior written notice to the Borrower and the Lenders. Such resignation shall take effect upon the acceptance by a successor the Administrative Agent of appointment
pursuant to clauses (b) and (c) below or as otherwise provided below. 
  
 (b) Upon any such notice of resignation, the Required Lenders shall appoint a successor Administrative Agent who shall be satisfactory to the Borrower and shall be an incorporated bank or trust company. 
  
 (c) If a successor Administrative Agent shall not have been so appointed
within said fifteen (15) Business Day period, the Administrative Agent, with the consent of the Borrower, shall then appoint a successor Administrative Agent who shall serve as the Administrative Agent until such time, if any, as the Required
Lenders, with the consent of the Borrower, appoint a successor Administrative Agent as provided above. 
  
 (d) If no successor Administrative Agent has been appointed pursuant to clause (b) or (c) by the twentieth (20th) Business Day after the date such notice
of resignation was given by Administrative Agent, Administrative Agent’s resignation shall become effective and the Required Lenders shall thereafter perform all the duties of Administrative Agent hereunder until such time, if any, as the
Required Lenders, with the consent of Borrower, appoint a successor Administrative Agent as provided above. 
  
 Section 7.10 Application of Article VII to Letter of Credit Issuer. The provisions of this Article VII and the obligations of the Lenders
thereunder shall be deemed equally to apply to, and be for the benefit of, the Letter of Credit Issuer and the Letter of Credit Issuer-Related Persons in connection with their administration of the Letters of Credit, the Letter of Credit Obligations
and the terms and provisions of Section 2.15, to the same extent that such provisions apply to the Administrative Agent, the Administrative Agent-Related Persons, the Loans and the Obligations, mutatis mutandis. 
  
 Section 7.11 Co-Agents. Nothing in this Agreement shall impose on the
Joint Lead Arrangers, the Syndication Agent or the Co-Documentation Agents in such capacities, any duties or obligations. 
  
 ARTICLE VIII 
  
 CHANGE IN CIRCUMSTANCES 
  
 Section 8.01 Basis for Determining Interest Rate Inadequate or Unfair. If on or prior to the first day of any Interest Period for any LIBOR Borrowing: 
  
 (a) the Administrative Agent is advised by Wells Fargo that deposits in
dollars (in the applicable amounts) are not being offered to Wells Fargo in the relevant market for such Interest Period, or 
  

 41 

 (b) Lenders having 51% or more of the aggregate amount of the Commitments advise the Administrative Agent
that the LIBOR Rate as determined by the Administrative Agent will not adequately and fairly reflect the cost to such Lenders of funding their LIBOR Loans for such Interest Period, 
  
 the Administrative Agent shall forthwith give notice thereof to the Borrower and the Lenders, whereupon until the Administrative Agent
notifies the Borrower that the circumstances giving rise to such suspension no longer exist, the obligations of the Lenders to make LIBOR Loans shall be suspended. Unless the Borrower notifies the Administrative Agent at least two Business Days
before the date of any LIBOR Borrowing for which a Notice of Borrowing has previously been given that it elects not to borrow on such date, any such LIBOR Borrowing shall instead be made as a Base Rate Borrowing. 
  
 Section 8.02 Illegality. If on or after the Effective Date, the
adoption of any applicable law, rule or regulation, or any change therein, or any change in the interpretation or administration thereof by any governmental authority, central bank or comparable agency charged with the interpretation or
administration thereof, or compliance by any Lender (or its LIBOR Lending Office) with any request or directive (whether or not having the force of law) of any such authority, central bank or comparable agency shall make it unlawful or impossible
for any Lender (or its LIBOR Lending Office) to make, maintain or fund its LIBOR Loans and such Lender shall so notify the Administrative Agent, the Administrative Agent shall forthwith give notice thereof to the other Lenders and the Borrower,
whereupon until such Lender notifies the Borrower and the Administrative Agent that the circumstances giving rise to such suspension no longer exist, the obligation of such Lender to make LIBOR Loans shall be suspended. Before giving any notice to
the Administrative Agent pursuant to this Section, such Lender shall designate a different LIBOR Lending Office if such designation will avoid the need for giving such notice and will not, in the judgment of such Lender, be otherwise disadvantageous
to such Lender. If such Lender shall determine that it may not lawfully continue to maintain and fund any of its outstanding LIBOR Loans to maturity and shall so specify in such notice, the Borrower shall immediately prepay in full the then
outstanding principal amount of each such LIBOR Loan, together with accrued interest thereon. Concurrently with prepaying each such LIBOR Loan, the Borrower shall borrow a Base Rate Loan in an equal principal amount from such Lender (on which
interest and principal shall be payable contemporaneously with the related LIBOR Loans of the other Lenders), and such Lender shall make such a Base Rate Loan. 
  

Section 8.03 Increased Cost and Reduced Return. 
  
 (a) If on or after the Effective Date, the adoption of any applicable law, rule or regulation, or any change therein, or any change in the interpretation
or administration thereof by any governmental authority, central bank or comparable agency charged with the interpretation or administration thereof, or compliance by any Lender (or its Applicable Lending Office) with any request or directive
(whether or not having the force of law) of any such authority, central bank or comparable agency: 
  
 (i) shall subject any Lender (or its Applicable Lending office) to any tax, duty or other charge with respect to its LIBOR Loans, its
Notes, its obligation to make LIBOR Loans or its Letter of Credit Obligations (collectively, its “Covered 
  

 42 

 Credits”), or shall change the basis of taxation of payments to any Lender (or its Applicable
Lending Office) of the principal of or interest on its LIBOR Loans or any other amounts due under this Agreement in respect of its Covered Credits (except for changes in the rate of tax on the overall net income of such Lender or its Applicable
Lending Office imposed by the jurisdiction in which such Lender’s principal executive office or Applicable Lending Office is located); or 
  
 (ii) shall impose, modify or deem applicable any reserve (including, without limitation, any such requirement imposed by the Board of
Governors of the Federal Reserve System, but excluding with respect to any LIBOR Loan any such requirement included in an applicable LIBOR Reserve Percentage), special deposit, insurance assessment or similar requirement against assets of, deposits
with or for the account of, or credit extended by, any Lender (or its Applicable Lending Office) or shall impose on any Lender (or its Applicable Lending Office) or on the United States market for the London interbank market any other condition
affecting its Covered Credits; 
  
 and the result of any of the foregoing is to
increase the cost to such Lender (or its Applicable Lending Office) of making or maintaining any Covered Credits, or to reduce the amount of any sum received or receivable by such Lender (or its Applicable Lending Office) under this Agreement or
under its Note with respect thereto, by an amount deemed by such Lender to be material, then, within 15 days after demand by such Lender (with a copy to the Administrative Agent), the Borrower shall pay to such Lender such additional amount or
amounts as will compensate such Lender for such increased cost or reduction. 
  
 (b) If any Lender shall have determined that, after the Effective Date, the adoption of any applicable law, rule or regulation regarding capital adequacy, or any change therein, or any change in the interpretation or
administration thereof by any governmental authority, central bank or comparable agency charged with the interpretation or administration thereof, or any request or directive regarding capital adequacy (whether or not having the force of law) of any
such authority, central bank or comparable agency, has or would have the effect of reducing the rate of return on capital of such Lender (or its Parent) as a consequence of such Lender’s obligations hereunder to a level below that which such
Lender (or its Parent) could have achieved but for such adoption, change, request or directive (taking into consideration its policies with respect to capital adequacy) by an amount deemed by such Lender to be material, then from time to time,
within 15 days after demand by such Lender (with a copy to the Administrative Agent), the Borrower shall pay to such Lender such additional amount or amounts as will compensate such Lender (or its Parent) for such reduction. 
  
 (c) Each Lender will promptly notify the Borrower and the Administrative
Agent of any event of which it has knowledge, occurring after the Effective Date, which will entitle such Lender to compensation pursuant to this Section and will designate a different Applicable Lending Office if such designation will avoid the
need for, or reduce the amount of, such compensation and will not, in the judgment of such Lender, be otherwise disadvantageous to such Lender. A certificate of any Lender claiming compensation under this Section and setting forth the additional
amount or amounts to be paid to it hereunder shall be conclusive in the absence of manifest error. In determining such amount, such Lender may use any reasonable averaging and attribution methods. 
  

 43 

 Section 8.04 Base Rate Loans Substituted for Affected LIBOR Loans. If (i) the obligation of any
Lender to make LIBOR Loans has been suspended pursuant to Section 8.02 or (ii) any Lender has demanded compensation under Section 8.03(a) and the Borrower shall, by at least five Business Days’ prior notice to such Lender through
the Administrative Agent, have elected that the provisions of this Section shall apply to such Lender, then, unless and until such Lender notifies the Borrower that the circumstances giving rise to such suspension or demand for compensation no
longer apply: 
  
 (a) all Loans which would otherwise be made by
such Lender as LIBOR Loans shall be made instead as Base Rate Loans (on which interest and principal shall be payable contemporaneously with the related LIBOR Loans of the other Lenders), and 
  
 (b) after each of its LIBOR Loans has been repaid, all payments of principal
which would otherwise be applied to repay such LIBOR Loans shall be applied to repay its Base Rate Loans instead. 
  
 ARTICLE IX 
  
 MISCELLANEOUS 
  
 Section 9.01 Notices. All
notices, requests and other communications to any party hereunder shall be in writing (including bank wire, telex, facsimile transmission or similar writing) and shall be given to such party: (x) in the case of the Borrower or the Administrative
Agent, at its address or telex number set forth on Schedule 9.01 hereto, (y) in the case of any Lender, at its address or telex number set forth in its Administrative Questionnaire or (z) in the case of any party, such other address or telex
number as such party may hereafter specify for the purpose by notice to the Administrative Agent and the Borrower. Each such notice, request or other communication shall be affective (i) if given by telex, when such telex is transmitted to the telex
number specified in this Section and the appropriate answerback is received, (ii) if given by mail, 72 hours after such communication is deposited in the mails with first class postage prepaid, addressed as aforesaid or (iii) if given by any other
means, when delivered at the address specified in this Section; provided that notices to the Administrative Agent under Article II or Article VIII shall not be effective until received. 
  
 Section 9.02 No Waivers. No failure or delay by the Administrative
Agent or any Lender in exercising any right, power or privilege hereunder or under any Note shall operate as a waiver thereof nor shall any single or partial exercise thereof preclude any other or further exercise thereof or the exercise of any
other right, power or privilege. The rights and remedies herein provided shall be cumulative and not exclusive of any rights or remedies provided by law. 
  
 Section 9.03 Expenses; Documentary Taxes; Indemnification. 
  
 (a) The Borrower shall pay (i) all reasonable out-of-pocket expenses of the Administrative Agent, including fees and
disbursements of counsel for the Administrative Agent, in connection with the preparation of this Agreement, (ii) all reasonable out-of-pocket expenses of the Administrative Agent, including fees and disbursements of counsel to the Administrative
Agent, in connection with any waiver or consent hereunder or any amendment hereof or any 
  

 44 

 Default or alleged Default hereunder, (iii) any civil penalty or fine assessed by OFAC against any Lender, the
Administrative Agent or the Letter of Credit Issuer and all reasonable costs and expenses (including counsel fees and disbursements) incurred in connection with defense thereof, as a result of the funding Loans or the acceptance of payments due
under a Loan Document, and (iv) if an Event of Default occurs, all out-of-pocket expenses incurred by the Administrative Agent and each Lender, including fees and disbursements of outside counsel, in connection with such Event of Default and
collection, bankruptcy, insolvency and other enforcement proceedings resulting therefrom. The Borrower shall indemnify each Lender against any transfer taxes, documentary taxes, assessments or charges made by any governmental authority by reason of
the execution and delivery of this Agreement or the Notes. 
  
 (b)
The Borrower agrees to indemnify each Lender, the Administrative Agent, the Letter of Credit Issuer, each Co-Documentation Agent, each Co-Syndication Agent and each of their respective Affiliates, officers, directors, employees and agents (each an
“Indemnified Party”) and hold each Indemnified Party harmless from and against any and all liabilities, losses, damages, costs and expenses of any kind, including, without limitation, the reasonable fees and disbursements of counsel, which
may be incurred by any Indemnified Party (including, without limitation, by the Administrative Agent in connection with its actions as Administrative Agent hereunder) in connection with any investigative, administrative or judicial proceeding
(whether or not such Indemnified Party shall be designated a party thereto) relating to or arising out of this Agreement or any actual or proposed use of proceeds of Loans hereunder or any actual or proposed use of any Letter of Credit;
provided that no Indemnified Party shall have the right to be indemnified hereunder for its own gross negligence or willful misconduct. The obligations of the Borrower under this Section 9.03 shall survive the payment in full of the
Notes and other Obligations and the termination of this Agreement. 
  
 Section 9.04 Sharing of Set-Offs. Each Lender agrees that if it shall, by exercising any right of set-off or counterclaim or otherwise, receive payment of a proportion of the aggregate amount of principal and interest due with
respect to any Revolving Note, Term Note or other Obligation held by it which is greater than the proportion received by any other Lender in respect of the aggregate amount of principal and interest due with respect to any such Note or other
Obligation held by such other Lender, the Lender receiving such proportionate greater payment shall purchase such participations in such other Notes or such other Obligations held by the other Lenders, and such other adjustments shall be made, as
may be required so that all such payments of principal and interest with respect to such other Notes or such other Obligations held by the Lenders shall be shared by the Lenders pro rata; provided that nothing in this Section shall impair the
right of any Lender to exercise any right of set-off or counterclaim it may have and to apply the amount subject to such exercise to the payment of indebtedness of the Borrower other than its indebtedness under the Notes or other Obligations. The
Borrower agrees, to the fullest extent it may effectively do so under applicable law, that any holder of a participation in a Note or other Obligation, whether or not acquired pursuant to the foregoing arrangements, may exercise rights of set-off or
counterclaim and other rights with respect to such participation as fully as if such holder of a participation were a direct creditor of the Borrower in the amount of such participation. 
  
 Section 9.05 Amendments and Waivers. Any provision of this Agreement or the Notes may be amended or waived if, but
only if, such amendment or waiver is in writing and is signed 
  

 45 

 by the Borrower and the Required Lenders (and, if the rights or duties of the Administrative Agent or the Letter of
Credit Issuer are affected thereby, by the Administrative Agent or the Letter of Credit Issuer, as the case may be); provided that no such amendment or waiver shall, unless signed by all the Lenders, (i) increase or decrease the Commitment of
any Lender (except for a ratable decrease in the Commitments of all Lenders), (ii) reduce the principal of or rate of interest on any Loan, Letter of Credit Obligation or any fees hereunder, (iii) postpone the date fixed for any payment of principal
of or interest on any Loan, Letter of Credit Obligation or any fees hereunder or for any reduction or termination of any Commitment, or (iv) change the percentage of the Commitments or of the aggregate unpaid principal amount of the Notes or the
Letter of Credit Obligations, or the number of Lenders, which shall be required for the Lenders or any of them to take any action under this Section or any other provision of this Agreement. 
  
 Section 9.06 Successors and Assigns. 
  
 (a) The provisions of this Agreement shall be binding upon and inure to the
benefit of the parties hereto and their respective successors and assigns, except that the Borrower may not assign or otherwise transfer any of its rights under this Agreement without the prior written consent of all Lenders. 
  
 (b) Any Lender may at any time grant to one or more banks or other
institutions (each a “Participant”) participating interests in its Commitment or any or all of its Loans and Letter of Credit Obligations, provided that such grant is in a pro rata portion of such Lender’s Revolving and
Term Commitments, Revolving and Term Notes, and Letter of Credit Obligations. In the event of any such grant by a Lender of a participating interest to a Participant, whether or not upon notice to the Borrower and the Administrative Agent, such
Lender shall remain responsible for the performance of its obligations hereunder, and the Borrower and the Administrative Agent shall continue to deal solely and directly with such Lender in connection with such Lender’s rights and obligations
under this Agreement. Any agreement pursuant to which any Lender may grant such a participating interest shall provide that such Lender shall retain the sole right and responsibility to enforce the obligations of the Borrower hereunder including,
without limitation, the right to approve any amendment, modification or waiver of any provision of this Agreement; provided that such participation agreement may provide that such Lender will not agree to any modification, amendment or waiver
of this Agreement described in clause (i), (ii) or (iii) of Section 9.05 without the consent of the Participant. An assignment or other transfer which is not permitted by subsection (c) or (d) below shall be given effect for purposes of this
Agreement only to the extent of a participating interest granted in accordance with this subsection (b). 
  
 (c) Any Lender may at any time assign to one or more banks or other financial institutions (each an “Assignee”) all, or a proportionate
part (such portion to be in an amount equal to or greater than $5,000,000) of all, of its rights and obligations under this Agreement, the Notes and the Letter of Credit Obligations, and such Assignee shall assume such rights and obligations,
pursuant to an assignment and assumption agreement in substantially the form of Exhibit C hereto (an “Assignment and Assumption Agreement”) executed by such Assignee and such transferor Lender, with (and subject to) the
subscribed consent of the Borrower and the Administrative Agent, such consents not to be unreasonably withheld; provided, that such grant is in a pro rata portion of such Lender’s Revolving and Term 
  

 46 

 Commitments, Revolving and Term Notes, and Letter of Credit Obligations; provided futher that an Assignee
not an Affiliate of such transferor Lender or another Lender must be a financial institution with combined capital and surplus in excess of $250,000,000; provided further that if an Assignee is an Affiliate of such transferor Lender
(including a trust established to administer loans sold by such Lender or its Affiliates to such trust, which trust is and shall continue to be administered by such Lender or an Affiliate thereof) neither the Borrower’s nor the Administrative
Agent’s consent shall be required, provided that such transferor Lender shall remain fully obligated under this Agreement for all funding and payment obligations; and provided further that if an Event of Default has occurred and
is continuing, the Borrower’s consent shall not be required. Upon execution of an Assignment and Assumption Agreement and the payment of a nonrefundable assignment fee of $3,500 in immediately available funds to the Administrative Agent at its
Payment Office in connection with each such assignment written notice thereof by such transferor Lender to the Administrative Agent and the recording by the Administrative Agent of such assignment in the Register and the resulting effect upon the
Loans and Letter of Credit Obligations of the assigning Lender and the Assignee, the Assignee shall have, to the extent of such assignment, the same rights and benefits as it would have if it were a Lender hereunder and the holder of Notes and
Letter of Credit Obligations (provided that the Borrower and the Administrative Agent shall be entitled to continue to deal solely and directly with the assignor Lender in connection with the interests so assigned to the Assignee until written
notice of such assignment, together with payment instructions, addresses and related information with respect to the Assignee, shall have been given to the Borrower and the Administrative Agent by the assignor Lender and the Assignee) and, if the
Assignee has expressly assumed, for the benefit of the Borrower, some or all of the transferor Lender’s obligations hereunder, such transferor Lender shall be relieved of its obligations hereunder to the extent of such assignment and
assumption, and except as described above, no further consent or action by the Borrower, the Lenders or the Administrative Agent shall be required. If the Assignee is not incorporated under the laws of the United States of America or a state
thereof, it shall, prior to the first date on which interest or fees are payable hereunder for its account, deliver to the Borrower and the Administrative Agent certification as to exemption from deduction or withholding of any United States federal
income taxes in accordance with Section 2.14. Each Assignee shall take such Loans, Letter of Credit Obligations and Commitments subject to the provisions of this Agreement and to any request made, waiver or consent given or other action taken
hereunder, prior to the receipt by the Administrative Agent and the Borrower of written notice of such transfer, by each previous holder of such Loans, Letter of Credit Obligations and Commitments. Such Assignment and Assumption Agreement shall be
deemed to amend this Agreement and Schedule 1.1 hereto, to the extent, and only to the extent, necessary to reflect the addition of such Assignee as a Lender and the resulting adjustment of all or a portion of the rights and obligations of
such transferor Lender under this Agreement, the determination of its Revolving Commitment Percentage and Term Commitment Percentage (in each case, rounded to twelve decimal places), the Loans, the Letter of Credit Obligations and any new Notes to
be issued, at the Borrower’s expense, to such Assignee, and no further consent or action by the Borrower or the Lenders shall be required to effect such amendments. 
  
 (d) Notwithstanding any other provision set forth in this Agreement, any Lender may at any time pledge or assign all or any
portion of its rights under this Agreement and the other documents executed and delivered in connection herewith (including, without limitation, the Note held by it) to any Federal Reserve Bank in accordance with Regulation A of 
  

 47 

 the Federal Reserve Board without notice to, or the consent of, the Borrower or the Administrative Agent and with the
consent of the Borrower and the Administrative Agent, any Lender which is a fund may pledge all or any portion of its Note or Loans to its trustee in support of its obligations to its trustee. No such pledge or assignment shall release the
transferor Lender from its obligations hereunder. 
  
 (e) No
Assignee, Participant or other transferee of any Lender’s rights shall be entitled to receive any greater payment under Section 8.03 than such Lender would have been entitled to receive with respect to the rights transferred, unless such
transfer is made with the Borrower’s prior written consent or by reason of the provisions of Section 8.02 or 8.03 requiring such Lender to designate a different Applicable Lending Office under certain circumstances or at a time
when the circumstances giving rise to such greater payment did not exist. 
  
 (f) The Borrower hereby designates the Administrative Agent to serve as the Borrower’s Administrative Agent, solely for purposes of this Section 9.06 to maintain a register (the
“Register”) on which it will record the Loans made and Letter of Credit Obligations held by each of the Lenders and each repayment in respect of the principal amount of the Loans and Letter of Credit Obligations of each Lender.
Failure to make any such recordation, or any error in such recordation shall not affect the Borrower’s obligations in respect of such Loans. With respect to any Lender, the transfer of the rights to the principal of, and interest on, any Loan
or Letter of Credit Obligation shall not be effective until the transfer is recorded on the Register maintained by the Administrative Agent with respect to ownership of such Loan or Letter of Credit Obligation and prior to such recordation all
amounts owing to the transferor with respect to such Loan or Letter of Credit Obligation shall remain owing to the transferor. The registration of assignment or transfer of all or part of any Loans or Letter of Credit Obligations shall be recorded
by the Administrative Agent on the Register only upon the acceptance by the Administrative Agent of a properly executed and delivered Assignment and Assumption Agreement pursuant to Section 9.06(c). Coincident with the delivery of such an
Assignment and Assumption Agreement to the Administrative Agent for acceptance and registration of assignment or transfer of all or part of a Loan or Letter of Credit Obligation, or as soon thereafter as practicable, the assigning or transferor
Lender shall surrender the Note evidencing such Loan or Letter of Credit Obligation, and thereupon one or more new Notes in the same aggregate principal amount then owing to such assignor or transferor Lender shall be issued to the assigning or
transferor Lender and/or the new Lender. The Borrower agrees to indemnify the Administrative Agent from and against any and all losses, claims, damages and liabilities of whatsoever nature which may be imposed on, asserted against or incurred by the
Administrative Agent in performing its duties under this Section 9.06(f); provided that the Administrative Agent shall not have the right to be indemnified under this Section 9.06(f) for its own gross negligence or willful
misconduct. 
  
 Section 9.07 Collateral. Each of the
Lenders represents to the Administrative Agent and each of the other Lenders that in good faith is not relying upon any “margin stock” (as defined in Regulation U) as collateral in the extension or maintenance of the credit provided for in
this Agreement. 
  
 Section 9.08 GOVERNING LAW; SUBMISSION TO
JURISDICTION. THIS AGREEMENT AND EACH NOTE SHALL BE GOVERNED BY AND CONSTRUED IN 
  

 48 

 ACCORDANCE WITH THE LAWS OF THE STATE OF ILLINOIS, WITHOUT GIVING EFFECT TO THE APPLICATION OF CHOICE OF LAW PRINCIPLES.
THE BORROWER HEREBY SUBMITS TO THE NONEXCLUSIVE JURISDICTION OF THE UNITED STATES DISTRICT COURT FOR THE NORTHERN DISTRICT OF ILLINOIS AND OF ANY ILLINOIS STATE COURT SITTING IN COOK COUNTY FOR PURPOSES OF ALL LEGAL PROCEEDINGS ARISING OUT OF OR
RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY. THE BORROWER IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY OBJECTION WHICH IT MAY NOW OR HEREAFTER HAVE TO THE LAYING OF THE VENUE OF ANY SUCH PROCEEDING BROUGHT
IN SUCH A COURT AND ANY CLAIM THAT ANY SUCH PROCEEDING BROUGHT IN SUCH A COURT HAS BEEN BROUGHT IN AN INCONVENIENT FORUM. 
  
 Section 9.09 Counterparts; Integration. This Agreement may be signed in any number of counterparts, each of which shall be an original, with the
same effect as if the signatures thereto and hereto were upon the same instrument. This Agreement and the Fee Letters constitute the entire agreement and understanding among the parties hereto and supersede any and all prior agreements and
understandings, oral or written, relating to the subject matter hereof. 
  
 Section 9.10 Confidentiality. The Administrative Agent and each Lender represent that they will maintain the confidentiality of any written or oral information provided under this Agreement by or on behalf of the Borrower that is
identified by the Borrower at the time as being subject to this Section 9.10 (hereinafter collectively called “Confidential Information”), subject to the Administrative Agent’s and each Lender’s (a) obligation to
disclose any such Confidential Information pursuant to a request or order under applicable laws and regulations or pursuant to a subpoena or other legal process, (b) right to disclose any such Confidential Information to its bank examiners,
auditors, counsel and other professional advisors and to other Lenders, (c) right to disclose any such Confidential Information in connection with any litigation or dispute involving the Lenders and the Borrower or any of its Subsidiaries and
Affiliates and (d) right to provide such information to Participants, prospective Participants to which sales of participating interests are permitted pursuant to Section 9.06(b), prospective Assignees to which assignments of interests are
permitted pursuant to Section 9.06(c), and to actual or prospective counterparties (and their advisors) to any swap, securitization or derivative transaction referencing or involving any of its rights or obligations under this Agreement if
such Participant, prospective Participant, prospective Assignee or actual or prospective counterparty (and their advisors) agrees in writing to maintain the confidentiality of such information on terms substantially similar to those of this Section
as if it were a “Lender” party hereto if such Participant, prospective Participant or prospective Assignee agrees in writing to maintain the confidentiality of such information on terms substantially similar to those of this Section as if
it were a “Lender” party hereto. Notwithstanding the foregoing, any such information supplied to a Lender, Participant, prospective Participant or prospective Assignee under this Agreement shall cease to be Confidential Information if it
is or becomes known to such Person by other than unauthorized disclosure, or if it becomes a matter of public knowledge. 
  

 49 

 Section 9.11 Patriot Act Notification. The following notification is provided to the Borrower
pursuant to Section 326 of the USA Patriot Act of 2001, 31 U.S.C. Section 5318: 
  
 IMPORTANT INFORMATION ABOUT PROCEDURES FOR OPENING A NEW ACCOUNT. To help the government fight the funding of terrorism and money laundering activities, Federal law requires all Lenders to obtain, verify and record
information that identifies each person that opens an account, including any deposit account, treasury management account, loan, other extension of credit or other financial services product. What this means for the Borrowers: When the Borrower
opens an account, the Lenders will ask for, and the Borrower shall provide to such Lenders, the Borrower’s name, business address, taxpayer identification number and other information that will allow the Lenders to identify the Borrower. The
Lenders may also ask to see the Borrower’s legal organizational documents or other identifying documents 
  
 Section 9.12 WAIVER OF JURY TRIAL. EACH OF THE BORROWER, THE ADMINISTRATIVE AGENT AND THE LENDERS HEREBY IRREVOCABLY WAIVES ANY AND ALL RIGHT TO
TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS AGREEMENT OR THE TRANSACTIONS CONTEMPLATED HEREBY. 
  
 [Signature pages to follow] 
  

 50 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to be duly executed by their respective
authorized officers as of the day and year first above written. 
  

			
	SIGMA-ALDRICH CORPORATION
		
	By:	 	  

	Name:	 	 
	Title:	 	 
		
	By:	 	  

	Name:	 	 
	Title:	 	 

			
	WELLS FARGO BANK, NATIONAL ASSOCIATION, in its individual capacity and as Administrative Agent, Letter of Credit Issuer and Joint Lead Arranger
		
	By:	 	  

	Name:	 	 
	Title:	 	 
	
	Contact:
	Address:
	
	Telephone:
	Fax:

			
	WACHOVIA CAPITAL MARKETS, LLC, in its individual capacity and as Joint Lead Arranger
		
	By:	 	  

	Name:	 	 
	Title:	 	 
	
	Contact:
	Address:
	
	Telephone:
	Fax:

			
	WACHOVIA BANK, N.A., in its individual capacity and as Syndication Agent
		
	By:	 	  

	Name:	 	 
	Title:	 	 
	
	Contact:
	Address:
	
	Telephone:
	Fax:

			
	U.S. BANK N.A., in its individual capacity and as Co-Documentation Agent
		
	By:	 	  

	Name:	 	 
	Title:	 	 
	
	Contact:
	Address:
	
	Telephone:
	Fax:

	

			
	THE BANK OF TOKYO-MITSUBISHI, LTD., CHICAGO BRANCH in its individual capacity and as Co-Documentation Agent
		
	By:	 	  

	Name:	 	 
	Title:	 	 
	
	Contact:
	Address:
	
	Telephone:
	Fax:

			
	ABN AMRO BANK N.V., in its individual capacity and as Co-Documentation Agent
		
	By:	 	  

	Name:	 	 
	Title:	 	 
	
	Contact:
	Address:
	
	Telephone:
	Fax:

			
	BNP PARIBAS
		
	By:	 	  

	Name:	 	 
	Title:	 	 
	
	Contact:
	Address:
	
	Telephone:
	Fax:

			
	COMERICA BANK
		
	By:	 	  

	Name:	 	 
	Title:	 	 
	
	Contact:
	Address:
	
	Telephone:
	Fax:

			
	COMMERCE BANK, N.A.
		
	By:	 	  

	Name:	 	 
	Title:	 	 
	
	Contact:
	Address:
	
	Telephone:
	Fax:

			
	MIZUHO CORPORATE BANK, LTD.
		
	By:	 	  

	Name:	 	 
	Title:	 	 
	
	Contact:
	Address:
	
	Telephone:
	Fax:

			
	THE NORTHERN TRUST COMPANY
		
	By:	 	  

	Name:	 	 
	Title:	 	 
	
	Contact:
	Address:
	
	Telephone:
	 Fax:

 PRICING SCHEDULE – Revolving Facility 
  

																
	 	  	 Level I
 Status

	 	 	 Level II
 Status

	 	 	 Level III
 Status

	 	 	 Level IV
 Status

	 	 	 Level V
 Status

	 
	 LIBOR Margin
	  	0.175	%	 	0.195	%	 	0.275	%	 	0.400	%	 	0.600	%
	 Facility Fee Rate
	  	0.070	%	 	0.080	%	 	0.100	%	 	0.125	%	 	0.150	%
	 Utilization Fee Rate
	  	0.075	%	 	0.075	%	 	0.125	%	 	0.125	%	 	0.125	%
	 Base Rate Margin
	  	0.00	%	 	0.00	%	 	0.00	%	 	0.00	%	 	0.00	%

  
 PRICING SCHEDULE
– Term Facility 
  

																
	 	  	 Level I
 Status

	 	 	 Level II
 Status

	 	 	 Level III
 Status

	 	 	 Level IV
 Status

	 	 	 Level V
 Status

	 
	 LIBOR Margin
	  	0.250	%	 	0.270	%	 	0.400	%	 	0.525	%	 	0.725	%
	 Facility Fee Rate
	  	0.070	%	 	0.080	%	 	0.100	%	 	0.125	%	 	0.150	%
	 Base Rate Margin
	  	0.00	%	 	0.00	%	 	0.00	%	 	0.00	%	 	0.00	%

  
 “Level I
Status” exists at any date if, on such date, the Borrower’s Moody’s Rating is A1 or better and the Borrower’s S&P Rating is A+ or better. 
  
 “Level II Status” exists at any date if, on such date, (i) the Borrower has not qualified for Level I
Status and (ii) the Borrower’s Moody’s Rating is A2 or better and the Borrower’s S&P Rating is A or better. 
  
 “Level III Status” exists at any date if, on such date, (i) the Borrower has not qualified for Level I Status or Level II Status and (ii)
the Borrower’s Moody’s Rating is A3 or better and the Borrower’s S&P Rating is A- or better. 
  
 “Level IV Status” exists at any date if, on such date, (i) the Borrower has not qualified for Level I Status, Level II Status or Level
III Status, and (ii) the Borrower’s Moody’s Rating is Baa1 or better and the Borrower’s S&P Rating is BBB+ or better. 
  
 “Level V Status” exists at any date if, on such date, the Borrower has not qualified for Level I Status, Level II Status, Level III
Status or Level IV Status. 
  
 “Moody’s
Rating” means, at any time, the rating issued by Moody’s and then in effect with respect to the Borrower’s senior unsecured long-term debt securities without third-party credit enhancement. 
  
 “S&P Rating” means, at any time, the rating issued by
S&P and then in effect with respect to the Borrower’s senior unsecured long-term debt securities without third-party credit enhancement. 
  

 - 1 - 

 “Status” means Level I Status, Level II Status, Level III Status, Level IV Status or
Level V Status. 
  
 The LIBOR Margin, Facility Fee Rate and Utilization Fee Rate
shall be determined in accordance with the foregoing table based on the Borrower’s Status as determined from its then-current Moody’s and S&P Ratings. The credit rating in effect on any date for the purposes of this Schedule is that in
effect at the close of business on such date. If at any time the Borrower has no Moody’s Rating or S&P Rating, Level V Status shall exist. If at any time the Moody’s Rating and S&P Rating would not both have the same Status, the
Status associated with the higher rating shall apply unless the Status of the higher rating would be associated with a rating two or more ratings above the lower rating, in which case the Status associated with the rating immediately above the lower
rating shall apply. 
  
 Notwithstanding the foregoing, no decrease in the LIBOR
Margin, Facility Fee Rate or Utilization Fee Rate shall be effected if a Default or an Event of Default shall have occurred and be continuing on the date when such change would otherwise occur, it being understood that on the third (3rd) Business
Day immediately succeeding the day on which such Default or Event of Default is either waived or cured (assuming no other Default or Event of Default shall be then pending), such decrease shall be effected (on a prospective basis) in accordance with
the then most recently delivered Compliance Certificate. 
  

 - 2 - 

 SCHEDULE 1.01 
  
 REVOLVING COMMITMENTS 
  

				
	 Lender

	  	Commitment

	 Wells Fargo Bank, National Association
	  	$	30,000,000
	 Wachovia Bank, N.A.
	  	$	30,000,000
	 The Bank of Tokyo-Mitsubishi, Ltd., Chicago Branch
	  	$	21,250,000
	 U.S. Bank, N.A.
	  	$	17,500,000
	 ABN AMRO Bank, N.V.
	  	$	17,500,000
	 Commerce Bank, N.A.
	  	$	8,750,000
	 Comerica Bank
	  	$	6,250,000
	 The Northern Trust Company
	  	$	6,250,000
	 BNP Paribas
	  	$	6,250,000
	 Mizuho Corporate Bank, Ltd.
	  	$	6,250,000
	 TOTAL
	  	$	150,000,000

  
 TERM
COMMITMENTS 
  

				
	 Lender

	  	Commitment

	 Wells Fargo Bank, National Association
	  	$	30,000,000
	 Wachovia Bank, N.A.
	  	$	30,000,000
	 The Bank of Tokyo-Mitsubishi, Ltd., Chicago Branch
	  	$	21,250,000
	 U.S. Bank, N.A.
	  	$	17,500,000
	 ABN AMRO Bank, N.V.
	  	$	17,500,000
	 Commerce Bank, N.A.
	  	$	8,750,000
	 Comerica Bank
	  	$	6,250,000
	 The Northern Trust Company
	  	$	6,250,000
	 BNP Paribas
	  	$	6,250,000
	 Mizuho Corporate Bank, Ltd.
	  	$	6,250,000
	 TOTAL
	  	$	150,000,000

  
 Schedule 1.01

  

 - 1 - 

 SCHEDULE 4.05 
  
 LITIGATION 
  
 NONE 
  
 Schedule 4.05 
  

 - 1 - 

 SCHEDULE 4.06 
  
 ERISA 
  
 NONE 
  
 Schedule 4.06 
  

 - 1 - 

 SCHEDULE 4.09 
  
 Sigma-Aldrich Corporation 
 Subsidiaries List as of February 23, 2005 
  

							
	 Name of Entity - Principal Place of Business

	  	 Description of
Operations

	  	 State of
Incorporation

	  	 Date of
 Inc.

	 8
Sigma-Aldrich Corporation - St. Louis, MO
	  	Research Chemicals	  	Delaware	  	1975
				
	 1. Sigma-Aldrich Co. (Illinois)
	  	Research Chemicals	  	Illinois	  	1996
	 (A) Sigma Second Street Redevelopment Corporation
	  	Real Estate Holding	  	Missouri	  	1983
	 (B) Barton/ Second Street Redevelopment Corporation
	  	Real Estate Holding	  	Missouri	  	1988
	 (C) Barton Real Estate Holdings, Inc.
	  	Real Estate Holding	  	Missouri	  	1988
	 (D) Sigma Redevelopment Corporation
	  	Real Estate Holding	  	Missouri	  	1979
	 (E) 3506 South Broadway Redevelopment Corp.
	  	Real Estate Holding	  	Missouri	  	1995
	 (F) Second President Properties Company
	  	Research Chemicals	  	Missouri	  	1988
	 (G) Olive/Ewing/Laclede Redevelopment Corporation
	  	Real Estate Holding	  	Missouri	  	2000
	 (H) Midwest Consultants Co. - St. Louis, MO
	  	Research Chemicals	  	Missouri	  	1971
	 (i) Little Creek Farm, Inc. - Leslie, MO
	  	Dormant/Inactive	  	Missouri	  	1980
	 (I) Sigma F&D Division, Inc.
	  	Dormant/Inactive	  	Missouri	  	1974
	 (J) Sigma-Aldrich China, Inc.
	  	Research Chemicals	  	Missouri	  	1990
	 (K) Pathfinder Laboratories Company
	  	Dormant/Inactive	  	Missouri	  	1987
	 (L) Planetary Chemical Inc.
	  	Dormant/Inactive	  	Missouri	  	1951
	 (M) Sigma Pharmaceutical, Inc.
	  	Dormant/Inactive	  	Missouri	  	1971
	 (N) Sigma-Aldrich B.V. (Netherlands)
	  	Research Chemicals	  	Netherlands	  	2000
	 (i) Sigma-Aldrich Holding B.V. (Netherlands)
	  	Holding Company	  	Netherlands	  	2000
	 (ii) Sigma-Aldrich Chemie Holding GmbH (Germany)
	  	Research Chemicals	  	Germany	  	1985
	 (iii) Sigma-Aldrich Chemie GmbH (Germany)
	  	Research Chemicals	  	Germany	  	1974
	 (iv) Sigma-Aldrich Laborchemikalien GmbH (Germany)
	  	Research Chemicals	  	Germany	  	1997
	 (iii) Sigma-Aldrich Producktions GmbH (Germany)
	  	Research Chemicals	  	Germany	  	1998
	 (iii) Sigma-Ark GmbH (Germany)
	  	Research Chemicals	  	Germany	  	1997
	 (O) Sigma-Aldrich Italia S.r.l.- Milano, Italy
	  	Research Chemicals	  	Italy	  	1987
	 (I) Sigma-Aldrich S.r.l.- Milano, Italy
	  	Research Chemicals	  	Italy	  	2000
	 (P) Sigma-Aldrich Chemie Verwaltungs GmbH - Munich, Germany
	  	Research Chemicals	  	Germany	  	1983
	 (Q) Sigma-Aldrich Grundstucksverwaltung GmbH & Co. K.G. - Munich, Germany
	  	Research Chemicals	  	Germany	  	1974
	 (R) Sigma-Aldrich N.V./S.A. - Bornem, Belgium
	  	Research Chemicals	  	Belgium	  	1984
	 (i) Sigma Chemie B.V. (The Netherlands)
	  	Research Chemicals	  	Holland	  	1995
	 (S) Sigma-Aldrich Israel, Ltd. - Rehovot, Israel
	  	Research Chemicals	  	Israel	  	1969
	 (T) 5
Aldrich Chemical Foreign Holding Company - Milwaukee, WI
	  	Holding Company	  	Missouri	  	1989
	 (i) Sigma-Aldrich Chimie S.N.C. Partnership - Cedex, France
	  	Research Chemicals	  	France	  	1989
	 (ii) Sigma-Aldrich Chimie S.a.r.l. (France) - Cedex, France
	  	Research Chemicals	  	France	  	1987
	 (U) 5
Sigma Chemical Foreign Holding Company (Missouri)
	  	Holding Company	  	Missouri	  	1989
	 (V) 1,2
Aldrich Chemical Company, Inc. - Milwaukee, WI
	  	Research Chemicals	  	Delaware	  	1996
	 (i) GLM Holdings, Inc. - Milwaukee, WI
	  	Dormant/Inactive	  	Wisconsin	  	1991
	 (ii) Aldrich-Boranes, Inc..
	  	Dormant/Inactive	  	Delaware	  	1989
	 (W) Sigma-Aldrich Business Holdings, Inc.
	  	Real Estate Holding	  	Delaware	  	1996

							
	 (i) Sigma-Aldrich Research Biochemicals, Inc. - Natick, MA
	  	Research Chemicals	  	Delaware	  	1997
	 (i) Research Biochemicals Limited Partnership
	  	Dormant/Inactive	  	Massachusetts	  	1997
	 (X) Sigma-Aldrich Lancaster, Inc.
	  	Research Chemicals	  	Missouri	  	1996
	 (i) Techcare Systems, Inc. - Redwood, CA
	  	Research Chemicals	  	California	  	1984
	 (i) MedChem. Ltd. (Russia)
	  	Research Chemicals	  	Russia	  	1997
	 (ii) SAF-Lab (Russia)
	  	Research Chemicals	  	Russia	  	1998
	 (ii) TechMed Biochem, Ltd. (Russia)
	  	Dormant/Inactive	  	Russia	  	1994
	 (i) Chemical Trade, Ltd. (Russia)
	  	Research Chemicals	  	Russia	  	1996
	 (Y) 3,4,6
Sigma-Genosys of Texas, Inc. - Woodlands, Texas
	  	Research Chemicals	  	Texas	  	1987
	 (i) Sigma Genosys LP
	  	Research Chemicals	  	Texas	  	2001
	 (ii) Sigma Genosys Holdings, LLC
	  	Limited Liability Company	  	Missouri	  	2001
	 (ii) Sigma Genosys Japan KK
	  	Research Chemicals	  	Japan	  	2001
	 *(Z) FMI Holdings, Inc. (California) (anticipate deletion in Sept 2003)
	  	Dormant/Inactive	  	Delaware	  	1998
	 (AA) Supelco, Inc. - Bellefonte, PA
	  	Research Chemicals	  	Delaware	  	1996
	 (AB) James F. Burns Co., Inc.
	  	Dormant/Inactive	  	Missouri	  	1972
	 (AC) KL Acquisition Corp.
	  	Dormant/Inactive	  	Missouri	  	1990
	 (AD) Sigma Chemical Corp.
	  	Dormant/Inactive	  	Missouri	  	2001
	 (AE) 7
Sigma-Aldrich Biotechnology Holding Company, Inc.
	  	Holding Company	  	Missouri	  	2001
	 7 (i)
Sigma-Aldrich Biotechnology LP
	  	Research Chemicals	  	Missouri	  	2001
	 7 (i)
Sigma-Aldrich Biotechnology Investment LLC
	  	Limited Liability Company	  	Missouri	  	2001
	 *(AF) Sigma-Aldrich Logistik GmbH
	  	Research Chemicals	  	Germany	  	2004
	 2. Sigma-Aldrich Inc. - St. Louis, MO
	  	Sales & Marketing of Chemical Products	  	Wisconsin	  	1996
				
	 3. Sigma- Aldrich Finance Co. - Hamilton, Bermuda
	  	Holding Company	  	Missouri	  	1996
				
	 4. Sigma-Aldrich & Subs Foreign Sales Corporation - Barbados
	  	FSC	  	Barbados	  	1994
				
	 5. Sigma-Aldrich Company, Ltd. - Poole, England
	  	Research Chemicals	  	United Kingdom	  	1987
	 (A) Sigma - Aldrich Holding, Ltd. (U.K.)
	  	Dormant/Inactive	  	United Kingdom	  	1985
	 (i) Sigma-Genosys Limited (UK)
	  	Research Chemicals	  	United Kingdom	  	1997
	 (i) Sigma Chemical Company, Ltd. (U.K.)
	  	Dormant/Inactive	  	United Kingdom	  	1963
	 (ii) Wessex Biochemicals Ltd. (U.K.)
	  	Dormant/Inactive	  	United Kingdom	  	1963
	 (i) Aldrich Chemical Company, Ltd. (U.K.)
	  	Dormant/Inactive	  	United Kingdom	  	1959
	 (ii) Webnest, Ltd. (U.K.)
	  	Dormant/Inactive	  	United Kingdom	  	1973
	 (i) Bristol Organics Ltd. (U.K.)
	  	Dormant/Inactive	  	United Kingdom	  	1970
	 (i) B-Line Systems Limited (U.K.)
	  	Dormant/Inactive	  	United Kingdom	  	1990
	 * (i) Ultrafine Ltd.(U.K.)
	  	Chemical Manuf.	  	United Kingdom	  	1983
	 **(i) JRH Biosciences Limited (U.K.)
	  	Biopharmaceutical Manf.	  	United Kingdom	  	1999
				
	 6. Fluka Holding AG - Buchs, Switzerland
	  	Holding Company	  	Switzerland	  	1950
	 (A) Fluka Chemie GmbH (Switzerland)
	  	Research Chemicals	  	Switzerland	  	1999
	 (B) Fluka Production GmbH (Switzerland)
	  	Research Chemicals	  	Switzerland	  	1999
	 (i) Fluka GmbH (Switzerland)
	  	Holding Company	  	Switzerland	  	1999
	 (C) Fluka Chemical Corp. (Delaware)
	  	Dormant/Inactive	  	Delaware	  	1996
	 (D) Fluka Chemical Company, Ltd. (U.K.)
	  	Dormant/Inactive	  	United Kingdom	  	1967
				
	 7. Sigma-Aldrich Foreign Holding Company - St. Louis, Missouri
	  	Holding Company	  	Missouri	  	1989
	 (A) Sigma-Aldrich Handels GmbH - Vienna, Austria
	  	Research Chemicals	  	Austria	  	1993
	 (B) Sigma-Aldrich de Argentina S.A. - Buenos Aires, Argentina
	  	Research Chemicals	  	Argentina	  	1997

  

 3 

							
	 *(C) 9
Sigma-Aldrich Oceania Pty. Limited
	  	Holding Company	  	Australia	  	 
	 * 9 (i)
Sigma-Aldrich Pty., Limited - N.S.W. 2154, Australia
	  	Research Chemicals	  	Australia	  	1991
	 (ii) Sigma-Aldrich Australian General Partnership
	  	Holding Company	  	Australia	  	 
	 (iii) Sigma-Aldrich New Zealand Co.
	  	Research Chemicals	  	New Zealand	  	 
	 (ii) JRH Biosciences Pty Ltd.
	  	Serum Collection & Processing	  	Australia	  	2002
	 (D) Sigma-Aldrich Quimica Brasil Ltda. - Sao Paulo, Brazil
	  	Research Chemicals	  	Brazil	  	1992
	 (E) Sigma-Aldrich spol.. s.r.o. - Czech Republic
	  	Research Chemicals	  	Czech Republic	  	1992
	 (F) Sigma-Aldrich Canada, Ltd. - Ontario, Canada
	  	Research Chemicals	  	Canada	  	1980
	 (G) Sigma-Aldrich Denmark A/S - Denmark
	  	Research Chemicals	  	Denmark	  	1998
	 (H) Ya-Kemia Oy - Helsinki, Finland
	  	Research Chemicals	  	Finland	  	1994
	 (I) Sigma-Aldrich (OM) Ltd. - Athens, Greece
	  	Research Chemicals	  	Greece	  	1997
	 (J) Sigma-Aldrich Kft. - Budapest, Hungary
	  	Research Chemicals	  	Hungry	  	1993
	 (K) Sigma-Aldrich India (Bangalore) Branch
	  	Research Chemicals	  	India	  	1992
	 *(L) Sigma-Aldrich Chemicals Pvt Ltd.
	  	Research Chemicals	  	India	  	2003
	 (M) Sigma-Aldrich Financial Services Limited - Dublin, Ireland
	  	Holding Company	  	Ireland	  	1998
	 (N) Sigma-Aldrich Ireland Ltd. - Dublin, Ireland
	  	Research Chemicals	  	Ireland	  	1997
	 (O) Sigma-Aldrich Japan K.K. - Tokyo, Japan
	  	Research Chemicals	  	Japan	  	1986
	 * (i) Sigma-Aldrich Logistics KK
	  	Research Chemicals	  	Japan	  	1986
	 * (i) Sigma-Genosys Japan KK
	  	Research Chemicals	  	Japan	  	1997
	 (P) Sigma-Aldrich Korea, Ltd. - Seoul, Korea
	  	Research Chemicals	  	Korea	  	1995
	 (Q) Sigma-Aldrich Quimica, S.A. de C.V. (Mexico)
	  	Research Chemicals	  	Mexico	  	1993
	 (R) Sigma-Aldrich Norway AS - Oslo, Norway
	  	Research Chemicals	  	Norway	  	1996
	 (S) Sigma-Aldrich Sp. z.o.o - Piznan, Poland
	  	Research Chemicals	  	Poland	  	1994
	 (T) Sigma-Aldrich Quimica S.A. - Madrid, Spain
	  	Research Chemicals	  	Spain	  	1989
	 (i) i) Sigma-Aldrich Quimica S.A. (Portugal) Branch
	  	Research Chemicals	  	Portugal	  	1998
	 (U) Sigma-Aldrich Sweden AB - Stockholm, Sweden
	  	Research Chemicals	  	Sweden	  	1954
	 (V) Sigma-Aldrich Pte, Ltd. (Singapore)
	  	Research Chemicals	  	Singapore	  	1994
	 (i) Sigma-Aldrich (M) Sdn. Bhd.- Kuala Lumpur, Malaysia
	  	Research Chemicals	  	Malaysia	  	1997
	 (W) Sigma-Aldrich Pty. Ltd. - Midrand, South Africa
	  	Research Chemicals	  	South Africa	  	1995
				
	 8. Sigma-Aldrich Insurance Company Ltd.
	  	Insurance Company	  	Bermuda	  	2002
				
	 9. *Tetrionics
	  	Pharmacological Compound Manf	  	Wisconsin	  	1990
				
	 10. **CSI, US, Inc.
	  	Holding Company	  	Delaware	  	1998
				
	 (A) JRH BIosciences Inc.
	  	Biopharmaceutical Manf. & Ser	  	California	  	1979

	*	Denotes changes from last application. 

	**	Upon Acquisition 

  
 The above colors represent the following: 
  

			
	-	  	Dormant/Inactive Company

  

 4 

			
	-	  	Branch Office
	-	  	Sigma-Aldrich Company Ltd. (UK) includes the following divisions: Scotland, Sigma, Aldrich, Fluka, Sigma Production and Aldrich Production
	-	  	Ownership is as follows: Sigma-Aldrich Co. owns 95% of Sigma-Aldrich Grundstucksverwaltung GmbH & Co. K.G. (formerly Aldrich Chemie GmbH & Co. K.G. ) and Sigma-Aldrich Chemie
Verwaltungs GmbH (formerly Aldrich Chemie Verwaltungs G,bH) owns 5% of Sigma-Aldrich Grundstrcksverwaltung GmbH & Co. K.G. Sigma-Aldrich Co. owns 100% of Sigma-Aldrich Chemie Verwaltungs GmbH.
	-	  	Sigma-Aldrich Foreign Holding Co. owns all but 1 share by Renata Bouabci (naturalized Argentine citizen; with agreement requiring the transfer of the share upon termination of
employment.)
	-	  	Belgium law requires 2 shareholders. Sigma-Aldrich Co. owns 2498 shares and Sigma-Aldrich Corporation owns 2 share.

  
 Additional Joint Venture and
Partnership information. 
  

	1	Aldrich Chemical Company, Inc. own 60% of AAPL Joint Venture 

	2	Aldrich Chemical Company, Inc. owns 39.11% of CAMAG Chemie-Erzeugnisse and Adsorptionstechnik
AG 

	3	Sigma-Genosys, Inc. and Glen Research Corporation own 50.1% and 49.9% respectively of Genosys
Biotin Partners partnership. 

	4	Sigma-Genosys, Inc. own s 37.5% of Chemicus, Inc. (Chemicus, Inc. is an inactive company as
of 12/98) 

	5	Ownership interest in Sigma-Aldrich Chimie SNC partnership (France): Sigma Chemical Foreign
Holding Co. 23% and Aldrich Chemical Foreign Holding Co. 77%. 

	6	Ownership interest in Sigma-Genosys L.P. Sigma-Genosys Holdings, L.L.C. 99% and Sigma-Genosys
of Texas, Inc. 1%. 

	7	Ownership interest in Sigma-Aldrich Biotechnology L.P. Sigma-Aldrich Investment, L.L.C. 99%
and Sigma-Aldrich Biotechnology Holding Co., Inc. 1% 

	8	Sigma-Aldrich Corporation owns 7% investment of Procognia Limited (in the United
Kingdom) 

	9	Ownership interest in Sigma-Aldrich Australian General Partnership: Sigma-Aldrich Oceania
Pty. Limited 99% and Sigma-Aldrich Pty. Limited 1% 

  
 Schedule 4.09 
  

 - 1 - 

 SCHEDULE 5.07 
  
 EXISTING LIENS 
  
 None. 
  
 Schedule 5.07 
  

 - 1 - 

 SCHEDULE 9.01 
  
 NOTICE INFORMATION 
  
 Sigma-Aldrich Corporation 
 3050 Spruce Street 
 St. Louis, Missouri 63103 

			
	 Attention:
	 	 Larry D. Roeder

	 Telephone:
	 	 (314)286-8016

	 Facsimile:
	 	 (314) 286-6692

  
 Wells
Fargo Bank, National Association 
 230 W. Wacker Drive 
 Chicago, Illinois 60606 

			
	 Attention:
	 	 Steven M. Buehler

	 Telephone:
	 	 (312) 553-6651

	 Facsimile:
	 	 (312) 553-4783

  
 Schedule 9.01

  

 - 1 - 

 EXHIBIT A-1 
  

REVOLVING NOTE 
  
 Chicago, Illinois 
 February 23, 2005 
  
 FOR VALUE RECEIVED, the undersigned, SIGMA-ALDRICH CORPORATION, a Delaware
corporation (the “Borrower”), HEREBY PROMISES TO PAY to the order of                      (the “Lender”),
the principal sum of                      DOLLARS ($            ), or, if
less, the aggregate unpaid principal amount of the Revolving Loans (as defined in the Credit Agreement which is hereinafter defined; capitalized terms used herein and not otherwise defined herein shall have the meaning ascribed thereto in the Credit
Agreement) made by the Lender to the Borrower pursuant to the Credit Agreement, on the Revolving Loan Termination Date, together with interest on any and all principal amounts remaining unpaid hereunder from time to time outstanding. The unpaid
principal amount hereof shall bear interest at a fluctuating rate per annum equal to the appropriate fluctuating rate per annum for the Revolving Loans evidenced hereby, as determined from time to time in accordance with the provisions
of the Credit Agreement; provided, however, that following the occurrence and during the continuance of an Event of Default, the Borrower promises to pay the Lender interest on the unpaid principal amount hereof at the default rate as
provided in the Credit Agreement. Prior to maturity, whether by acceleration or otherwise, accrued interest shall be payable at such times as set forth in the Credit Agreement. After maturity, whether by acceleration or otherwise, accrued interest
shall be payable upon demand. Interest shall be computed as provided in the Credit Agreement. Both principal and interest are payable in lawful money of the United States of America to the Administrative Agent at the Payment Office, in immediately
available funds. The Revolving Loans made by the Lender to the Borrower pursuant to the Credit Agreement and all payments on account of principal hereof shall be recorded by the Lender and, prior to any transfer thereof, endorsed on the Revolving
Loan and Principal Payments Schedule attached hereto which is part of this Note. Amounts advanced hereunder may be repaid and reborrowed from time to time as provided for in the Credit Agreement. 
  
 This Promissory Note is a Revolving Note referred to in, and is entitled to
the benefits of, the Credit Agreement, dated as of February 23, 2005 (as amended, supplemented, restated, or otherwise modified from time to time, the “Credit Agreement”) by and among the Borrower, the financial institutions
signatory thereto (the “Lenders”), and Wells Fargo Bank, National Association as Administrative Agent (the “Administrative Agent”) for the Lenders, the terms, covenants, conditions, provisions, stipulations and
agreements of which are made a part hereof to the same extent and with the same effect as if fully set forth herein. The Credit Agreement, among other things, contains provisions for acceleration of the maturity hereof upon the happening of certain
stated events and also for prepayments on account of principal hereof prior to the maturity hereof upon the terms and conditions therein specified. 
  
 THE BORROWER HEREBY WAIVES PRESENTMENT, DEMAND, PROTEST OR NOTICE OF ANY KIND IN CONNECTION WITH THIS NOTE. 
  
 Exhibit A-1 
  

 - 1 - 

 THIS NOTE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF ILLINOIS WITHOUT
REGARD TO PRINCIPLES OF CONFLICT OF LAW. 
  
 IN WITNESS WHEREOF,
the Borrower has duly executed and delivered this Note as of the date first written above. 
  

			
	 SIGMA-ALDRICH CORPORATION

		
	 By
	 	  

	 Name:
	 	  

	 Title:
	 	  

  
 Exhibit A-1

  

 - 2 - 

 Schedule attached to Revolving Note of 
  
 SIGMA-ALDRICH CORPORATION 
  
 payable to the order to 
  
 [Insert name of Lender] 
  
 LOANS AND PRINCIPAL PAYMENTS 
  

									
	 Date and
 Loan
Number

	 	 Amount of Loan
 and Interest Rate

	 	 Amount of
 Payment and
 Loan Number
 to Which
 Applied

	 	 Principal
 Remaining
 Unpaid

	 	 Balance
 Notation
 Made By

	 	 	 	 
	 	 	 	 
	 	 	 	 
	 	 	 	 

  
  

 - 1 - 

 EXHIBIT A-2 
  

TERM NOTE 
  
 Chicago, Illinois 
 February 23, 2005 
  
 FOR VALUE RECEIVED, the undersigned, SIGMA-ALDRICH CORPORATION, a Delaware
corporation (the “Borrower”), HEREBY PROMISES TO PAY to the order of                      (the “Lender”),
the principal sum of                      DOLLARS ($            ), or, if
less, the aggregate unpaid principal amount of the Term Loans (as defined in the Credit Agreement which is hereinafter defined; capitalized terms used herein and not otherwise defined herein shall have the meaning ascribed thereto in the Credit
Agreement) made by the Lender to the Borrower pursuant to the Credit Agreement, on the Term Loan Termination Date, together with interest on any and all principal amounts remaining unpaid hereunder from time to time outstanding. The unpaid principal
amount hereof shall bear interest at a fluctuating rate per annum equal to the appropriate fluctuating rate per annum for the Term Loans evidenced hereby, as determined from time to time in accordance with the provisions of the Credit
Agreement; provided, however, that following the occurrence and during the continuance of an Event of Default, the Borrower promises to pay the Lender interest on the unpaid principal amount hereof at the default rate as provided in
the Credit Agreement. Prior to maturity, whether by acceleration or otherwise, accrued interest shall be payable at such times as set forth in the Credit Agreement. After maturity, whether by acceleration or otherwise, accrued interest shall be
payable upon demand. Interest shall be computed as provided in the Credit Agreement. Both principal and interest are payable in lawful money of the United States of America to the Administrative Agent at the Payment Office, in immediately available
funds. The Term Loans made by the Lender to the Borrower pursuant to the Credit Agreement and all payments on account of principal hereof shall be recorded by the Lender and, prior to any transfer thereof, endorsed on the Term Loan and Principal
Payments Schedule attached hereto which is part of this Note. Amounts advanced hereunder and repaid may not be reborrowed. 
  
 This Promissory Note is a Term Note referred to in, and is entitled to the benefits of, the Credit Agreement, dated as of February 23, 2005 (as amended,
supplemented, restated, or otherwise modified from time to time, the “Credit Agreement”) by and among the Borrower, the financial institutions signatory thereto (the “Lenders”), and Wells Fargo Bank, National
Association as Administrative Agent (the “Administrative Agent”) for the Lenders, the terms, covenants, conditions, provisions, stipulations and agreements of which are made a part hereof to the same extent and with the same effect
as if fully set forth herein. The Credit Agreement, among other things, contains provisions for acceleration of the maturity hereof upon the happening of certain stated events and also for prepayments on account of principal hereof prior to the
maturity hereof upon the terms and conditions therein specified. 
  
 THE BORROWER HEREBY WAIVES PRESENTMENT, DEMAND, PROTEST OR NOTICE OF ANY KIND IN CONNECTION WITH THIS NOTE. 
  
 THIS NOTE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF ILLINOIS WITHOUT REGARD TO PRINCIPLES OF CONFLICT OF LAW.

  
 Exhibit A-2 
  

 - 1 - 

 IN WITNESS WHEREOF, the Borrower has duly executed and delivered this Note as of the date first written
above. 
  

			
	 SIGMA-ALDRICH CORPORATION

		
	 By
	 	  

	 Name:
	 	  

	 Title:
	 	  

  
 Exhibit A-2

  

 - 2 - 

 Schedule attached to Term Note of 
  
 SIGMA-ALDRICH CORPORATION 
  
 payable to the order to 
  
 [Insert name of Lender] 
  
 LOANS AND PRINCIPAL PAYMENTS 
  

									
	 Date and
 Loan
Number

	 	 Amount of Loan
 and Interest Rate

	 	 Amount of
 Payment and
 Loan Number
 to Which
 Applied

	 	 Principal
 Remaining
 Unpaid

	 	 Balance
 Notation
 Ma

	 	 	 	 
	 	 	 	 
	 	 	 	 
	 	 	 	 

  

 - 1 - 

 EXHIBIT B 
  

February 23, 2005 
  
 To the Lenders and the Administrative Agent 
 Referred to Below 
 c/o Wells Fargo Bank, National Association, 
 as Administrative Agent 
  

  

  
 Ladies and Gentlemen:

  
 We have acted as counsel for Sigma-Aldrich Corporation (the
“Borrower”) in connection with the Credit Agreement (the “Credit Agreement”) dated as of February 23, 2005 among the Borrower, the Lenders listed on the signature pages thereof and Wells Fargo Bank, National Association as
Administrative Agent. Terms defined in the Credit Agreement are used herein as therein defined. This opinion is being rendered to you at the request of our client pursuant to Section 3.01(d) of the Credit Agreement. 
  
 In connection with the foregoing, we have examined executed copies of (a) the
Articles of Incorporation and By-laws of the Borrower, (b) the Credit Agreement and the Exhibits thereto, or (c) the Notes issued pursuant to the Credit Agreement. 
  
 We have also examined such other documents, certificates and corporate records and instruments and have made such
investigation of law as we deem necessary or appropriate for the purpose of enabling us to render this opinion. In our examination, we have assumed the genuineness of all signatures, the authenticity of all documents submitted to us as originals,
the conformity to original documents of all documents submitted to us as photostatic copies, the authenticity or originals of such copies, and the execution and delivery of all documents referred to herein and the due authorization of such execution
and delivery by all parties other than the Borrower. 
  
 Upon the
basis of the foregoing, we are of the opinion that: 
  
 1. The
Borrower is a corporation incorporated, validly existing and in good standing under the laws of Delaware, and has all corporate powers required to carry on its business as now conducted. 
  
 2. The execution, delivery and performance by the Borrower of the Credit Agreement and the Notes are within the
Borrower’s corporate powers, have been duly authorized by all necessary corporate action, require no action by or in respect of, or filing with, any governmental body, agency or official and do not contravene or 
  
 Exhibit B 
  

 - 1 - 

 
constitute a default, or result in the creation or imposition of any Lien on any asset of the Borrower or any of its Subsidiaries, under any provision of
applicable law or regulation or of the Articles of Incorporation or By-laws of the Borrower or, to the best of our knowledge, of any agreement, judgment, injunction, order, decree or other instrument binding upon the Borrower. 
  
 3. The Credit Agreement constitutes a valid and binding agreement of the
Borrower and the Notes constitute valid and binding obligations of the Borrower. 
  
 4. Neither the Borrower nor any of its Subsidiaries is an “investment company” registered or required to be registered under the Investment Company Act of 1940, as amended, or, to our knowledge, controlled
by such a company. 
  
 5. Neither the Borrower nor any of its
Subsidiaries is a “holding company” or a “subsidiary company” of a “holding company” or an “affiliate” of a “holding company” within the meaning of the public Utility Holding Company Act of 1935, as
amended. 
  
 The foregoing opinions are subject to the
qualifications that: 
  
 (a) The enforceability of any of the
Credit Agreement, the Notes, or any provisions contained therein may be limited by (i) applicable bankruptcy, receivership, reorganization, insolvency, fraudulent conveyance or transfer, moratorium or other similar laws affecting creditors’
rights generally, and (ii) general principles of equity, regardless of whether such enforcement is considered in a proceeding in equity or at law. 
  
 (b) The availability of specific performance, injunctive relief, or other equitable remedies is subject to the discretion of the Court before which such
proceedings thereof may be brought. 
  
 (c) Applicable laws and
judicial decisions may require that you exercise your rights under the Credit Agreement in good faith and in a commercially reasonable manner and a Court may not strictly enforce certain covenants therein if it concludes that such enforcement would
be unreasonable under the then-existing circumstances. 
  
 (d) We
are licensed to practice law in                      and do not hold ourselves out to be experts on the laws of any jurisdiction other than
                    , Delaware and the United States. Accordingly, we express no opinion with regard to any matter which may be governed by
the laws of any state or other jurisdiction other than                     , Delaware and the United States. 
  
 (e) Wherever this opinion refers to matters “within our knowledge”
or “to the best of our knowledge,” such reference means matters within our actual knowledge, based upon the personal knowledge of the attorneys who have provided legal services to the Borrower and a review of our files and inquiries of the
Borrower. Other than as stated, we have not reviewed any other files or records, made any search of public records or conducted any other investigation with respect to the matters referred to herein. 
  
 Exhibit B 
  

 - 2 - 

 This opinion is limited to the legal matters stated herein and no opinion is implied or may be inferred
beyond the matters expressly stated. 
  
 This opinion is provided
at your request and is to be limited in its use to reliance by you, and only with respect to this transaction. No other person or entity may rely or claim reliance upon this opinion without our prior written consent. 
  
 Very truly yours, 
  
 Exhibit B 
  

 - 3 - 

 EXHIBIT C 
  

FORM OF ASSIGNMENT AND ASSUMPTION AGREEMENT 
  
 Reference is made to the Credit Agreement dated as of February 23, 2005 by and among Sigma-Aldrich Corporation (the “Borrower”), Wells
Fargo Bank, National Association as Administrative Agent (the “Administrative Agent”), and the financial institutions parties thereto in their capacities as Lenders thereunder (as the same may be amended, supplemented, restated or
otherwise modified from time to time in accordance with its terms and in effect, the “Credit Agreement”) and, to the extent thereof, each of the Notes (as defined in the Credit Agreement). Capitalized terms used but not otherwise
defined herein shall have the respective meanings assigned to them in the Credit Agreement. 
  
 NOW, THEREFORE,
                                        
(the “Transferor”) and
                                        
(the “Transferee”) hereby agree as follows: 
  
 1. The Transferor hereby transfers and assigns to the Transferee, except with respect to indemnities of the Borrower, if any, which have not been satisfied and which shall have arisen prior to the Effective Date (as defined in Section
11 hereof), that interest in and to all the Transferor’s rights and obligations under the Credit Agreement as of the date hereof which represents the percentage interest specified in Item 2 of Schedule A to this Assignment Agreement
(“Assigned Portion”) and the Transferee hereby accepts said assignment and, to the extent of its respective interests therein, assumes the commitments and obligations established under the Credit Agreement with respect to the
Assigned Portion. The assignment affected hereby is without recourse against or warranty (except as provided in Section 4 below) by the Transferor. 
  
 2. In connection with the assignment affected hereby by the Transferor to the Transferee of the Assigned Portion with respect to the Credit Agreement.

  

	(a)	As of the Effective Date, the Transferee shall pay to the Transferor, in immediately available funds, an amount equal to the outstanding indebtedness owed to it by the Borrower
under the Credit Agreement with respect to the Assigned Portion. 

  

	(b)	From and after the Effective Date, (a) the Transferee shall (i) be a Lender party to the Credit Agreement for all purposes of the Credit Agreement and the Notes; (ii) be subject to
the terms and conditions thereof, and (iii) have all of the rights, interests, liabilities, duties and obligations of the Transferor under the Credit Agreement, the Notes and the Letter of Credit Obligations to the extent of the Assigned Portion;
and (b) the Transferor shall to the extent provided in this Assignment Agreement relinquish such rights and interest and be released from such liabilities, duties and obligations under the Credit Agreement, the Notes and the Letter of Credit
Obligations as shall have been assigned to the Transferee hereunder. 

  
 Exhibit C 
  

 - 1 - 

	(c)	From and after the Effective Date, the Administrative Agent shall make all payments under the Credit Agreement in respect of the Assigned Portion (including, without limitation, all
payments of principal, interest and fees, if applicable, with respect thereto) to the Transferee. The Transferor and Transferee shall make all appropriate adjustments in payments under the Credit Agreement for periods prior to the Effective Date
between themselves. 

  
 3. Each of the parties to
this Assignment Agreement agrees that at any time and from time to time upon the written request of any other party, it will execute and deliver such further documents and perform such further acts as such other party may reasonably request in order
to effect the purposes of this Assignment Agreement, provided neither this Assignment Agreement nor any term hereof may be changed, waived, discharged or terminated except by an instrument in writing signed by the party (including, if applicable,
any party required to evidence its consent to or acceptance of this Assignment Agreement) against whom enforcement of such change, waiver, discharge or termination is sought. 
  
 4. By executing and delivering this Assignment Agreement, the Transferor (a) represents and warrants that it is the legal
and beneficial owner of the interest being assigned hereby free and clear of any adverse claim; (b) makes no representation or warranty and assumes no responsibility with respect to any statements, warranties or representations made in or in
connection with the Credit Agreement or the execution, legality, validity, enforceability, genuineness, sufficiency or value of the Credit Agreement, any Note or any Letter of Credit Obligation, or any other instrument or document furnished pursuant
thereto; (c) makes no representation or warranty and assumes no responsibility with respect to the financial condition of the Borrower or any of its Subsidiaries, or the performance or observance by the Borrower or any of its Subsidiaries of any of
its obligations under the Credit Agreement, any Note or any Letter of Credit Obligation or any other instrument or document furnished pursuant hereto. 
  
 5. By executing and delivering this Assignment Agreement, the Transferee: (a) confirms that it has received a copy of the Credit Agreement, together with
copies of the financial statements referred to therein and such other documents and information as it has deemed appropriate to make its own credit analysis and decision to enter into this Assignment Agreement; (b) will independently and without
reliance upon the Administrative Agent, the Letter of Credit Issuer, Transferor or any other Lender, and based on such documents and information as it shall deem appropriate at the time, continue to make its own credit decisions in taking or not
taking action under the Credit Agreement; (c) appoints and authorizes the Administrative Agent to take such action as the Administrative Agent, and the Letter of Credit Issuer to take such action as Letter of Credit Issuer, on its behalf and to
exercise such powers under the Credit Agreement, the Notes and the Letters of Credit as are delegated to the Administrative Agent and the Letter of Credit Issuer by the terms thereof, together with such powers as are reasonably incidental thereto;
and (d) agrees that it will perform in accordance with their terms all of the obligations which by the terms of the Credit Agreement, the Notes and the Letter of Credit Obligations are required to be performed by it as a Lender. 
  
 6. Unless otherwise specifically provided herein, any notice or other
communication 
  
 Exhibit C 
  

 - 2 - 

 
herein required or permitted to be given shall be in writing and may be personally served, telexed or sent by facsimile or United States mail or courier
service. For purposes hereof, the notice address of each party hereto shall be as set forth on Schedule A hereto or, as to either party, such other address as shall be designated by such party in writing. 
  
 7. Each of Transferor and the Transferee represents and warrants to the
Borrower and the Administrative Agent that after giving effect to the assignment of the Assigned Portion affected hereby, each of the Transferor and the Transferee is in compliance with the provisions of Section 9.06 of the Credit Agreement.

  
 8. This Assignment Agreement may be executed in any number of
counterparts and by different parties hereto in separate counterparts, each of which when so executed and delivered shall be deemed to be an original and all of which taken together shall constitute but one and the same instrument. 
  
 9. THIS ASSIGNMENT AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN
ACCORDANCE WITH THE INTERNAL LAWS OF THE STATE OF ILLINOIS WITHOUT REFERENCE TO THE PROVISIONS THEREOF REGARDING CONFLICTS OF LAW. 
  
 10. No assignment effected pursuant to this Assignment Agreement shall constitute a novation of the obligations of the Borrower being assigned.

  
 11. This Assignment Agreement shall become effective on the
date (the “Effective Date”) upon which all of the following conditions are satisfied: (i) the execution of a counterpart hereof by each of the Transferor and Transferee; (ii) the execution of a counterpart hereof by the Borrower and
the Administrative Agent as evidence of its consent hereto to the extent required under Section 9.06(c) of the Credit Agreement; (iii) the receipt by the Administrative Agent of the processing and recordation fee referred to in Section 9.06(c) of
the Credit Agreement; (iv) in the event the Transferee is not a United States person, the delivery by the Transferee to the Administrative Agent of such forms, certificates or other evidence with respect to United States federal income tax
withholding matters as Transferee may be required to deliver to the Administrative Agent pursuant to said Section 2.14; and (v) the receipt by the Administrative Agent of originals or facsimiles of the counterparts described above and authorization
of delivery thereof; provided, however, that for all purposes under this Assignment Agreement, the term “Settlement Date” shall mean the later of (a) the date specified in Item 3 of Schedule A hereto and (b) the
Effective Date. 
  
 IN WITNESS WHEREOF, the parties hereto have
caused this Assignment Agreement to be executed and delivered by their respective officers thereunto duly authorized, such execution being made as of the Effective Date in the applicable spaces provided on Schedule A hereto. 
  
 Exhibit C 
  

 - 3 - 

 SCHEDULE A 
 TO THE ASSIGNMENT AND ASSUMPTION AGREEMENT 
  

	1.	Name and Date of Credit Agreement: Credit Agreement, dated as of February 23, 2005 by and among Sigma-Aldrich Corporation, the financial institutions parties thereto as
Lenders and Wells Fargo Bank, National Association as Administrative Agent for the Lenders, as the same may be amended, supplemented, restated or otherwise modified from time to time. 

  

	2.	Assigned Portions1: 

  

					
	 (a)
	  	 Aggregate
	  	 
	 	  	 Commitments of All Lenders
	  	 $                    

			
	 (b)
	  	 Assigned Share
	  	                       %

			
	 (c)
	  	 Amount of Assigned Share
	  	 $                    

  

	3.	Settlement Date:
                                        ,
             

  

	4.	Payment Instructions: 

					
	 TRANSFEROR:
	  	TRANSFEREE:	  	 
			
	 Attn:
	  	Attn:	  	 
	 Ref:
	  	Ref:	  	 

  

	5.	Notice of Address: 

					
	 TRANSFEROR:
	  	TRANSFEREE:	  	 
			
	 Attn:
	  	Attn:	  	 
	 Ref:
	  	Ref:	  	 

	1	Assigned portions must be pro rata between Revolving and Term Commitments, Revolving and Term Notes and Letter of Credit Obligations. 

  
 Schedule A 
  

 - 1 - 

	6.	SIGNATURES: 

  

					
	 	 	 [NAME OF TRANSFEROR]

			
	 	 	 By
	 	  

	 	 	 Title:
	 	 

  

			
	
	 [NAME OF TRANSFEREE]

		
	 By:
	 	  

	 Title:
	 	 
	
	 Consented to in accordance with Section 9.06(c) of
 the Credit Agreement

	
	 SIGMA-ALDRICH CORPORATION

		
	 By:
	 	  

	 Title:
	 	 
	
	 SIGMA-ALDRICH CORPORATION

		
	 By:
	 	  

	 Title:
	 	 

  
 Schedule A 

 

 - 2 - 

			
	Accepted in accordance with Section 9.06(c) of the Credit Agreement
	
	 WELLS FARGO BANK,
 NATIONAL
ASSOCIATION,
 as Administrative Agent

		
	By:	 	  

	Title:	 	 

  
 Schedule A 

 

 - 3 - 

 EXHIBIT D 
 FORM OF COMPLIANCE CERTIFICATE 
  
 Wells Fargo Bank, National Association 
 as Administrative Agent for the Lenders party

 to the Credit Agreement referred to below 
 230 West Monroe 
 Chicago, Illinois 60606 
  
 Attn:
                                     
  
 Ladies and Gentlemen: 
  
 This certificate is furnished to you by Sigma-Aldrich Corporation (the
“Borrower”), pursuant to Section 5.01(c) of that certain Credit Agreement, dated as of February 23, 2005, among the Borrower, the lenders party thereto (the “Lenders”), Wells Fargo Bank, National Association, as Administrative
Agent (as the same may be amended, restated, supplemented or otherwise modified from time to time, the “Credit Agreement”), concurrently with the delivery of the financial statements required pursuant to Sections 5.01(a) and (b) of the
Credit Agreement. Terms not otherwise defined herein are used herein as defined in the Credit Agreement. 
  
 The undersigned, on behalf of the Borrower, hereby certifies that: 
  
 (A) no Default or Event of Default has occurred and is continuing, except as described in Attachment 1 hereto; 

 
 (B) the financial data and computations set forth in Schedule 1 below,
evidencing compliance with the covenants set forth in Sections 5.05, 5.06, 5.07 and 5.11 of the Credit Agreement, are true and correct as of
                    ,             2 (the “Computation Date”); and 
  
 (C) if the financial statements of the Borrower being concurrently delivered
were not prepared in accordance with GAAP, Attachment 2 hereto sets forth any derivations required to conform the relevant data in such financial statements to the computations set forth below. 
  
 The foregoing certifications, together with the computations set forth in
Schedule 1 hereto and the financial statements delivered with this Compliance Certificate in support hereof, are made and delivered as of this              day of
                    ,         . 
  

			
	SIGMA-ALDRICH CORPORATION
		
	 By:
	 	  

	 Name:
	 	  

  
 Title: Chief Financial Office

	2	The last day of the accounting period for which financial statements are being concurrently delivered. 

 Exhibit D 
  

 - 1 - 

 SCHEDULE 1 
  
 Computations 
  

				
	 I.       Section 5.05 Capitalization Ratio and Pricing Schedule
	  	 	 
	 Period: Fiscal Quarter ended                     
    ,             .
	  	 	 
	 1.      Maximum Permitted:
	  	 	0.55:1.0
	 2.      Actual:
	  	 	 
	 (a)    Consolidated Debt as of the period referred to above:
	  	$	                    
	 (b)    Consolidated Debt plus Consolidated Net Worth for the period referred to above:
	  	$	                    
	 (c)    Ratio of (a) to (b):
	  	 	        :1.0
	 3.      Status under the Pricing Schedule
	  	 
 	Level             
Status
	 II.     Section 5.06 Consolidated Net Worth
	  	 	 
	 Period: Fiscal Quarter ended:
                    
	  	 	 
	 1.      Minimum Required:
	  	$	750,000,000
	 2.      Actual:
	  	$	 
	 3.      If (1) is greater than (2), then Borrower is in compliance with Section 5.06
	  	 
 	yes             
no
            
	 III.    Section 5.07(d) Negative Pledge and Section 5.11(d) Limitation on Debt
	  	 	 
	 1.      20% of the Consolidated Net Worth as of the date of this certificate:
	  	$	                    
	 2.      Borrower’s aggregate outstanding Debt as described in Section 5.07(a):
	  	$	                    
	 3.      Borrower’s aggregate outstanding Debt as described in Section 5.07(b):
	  	$	                    
	 4.      Borrower’s aggregate outstanding Debt as described in Section 5.07(d):
	  	$	                    
	 5.      Subsidiaries’ aggregate outstanding Debt as described in Section 5.11(a):
	  	$	                    
	 6.      Subsidiaries’ aggregate outstanding unsecured Debt as described in Section 5.11(d):
	  	$	                    
	 7.      (2) plus (3) plus (4) plus (5) plus (6)
	  	$	                    
	 8.      If (1) is greater than (7), then Borrower is in compliance with Sections 5.07(d) and
5.11(d)
	  	 
 	yes             
no             

  
 Schedule 1 

 

 - 1 - 

 ATTACHMENT 1 
 DESCRIPTION OF ANY DEFAULTS OR EVENTS OF DEFAULT 
  
 Attachment 1 
  

 - 1 - 

 ATTACHMENT 2 
 DERIVATIONS REQUIRED TO CONFORM RELEVANT DATA IF FINANCIAL 
 STATEMENTS WERE NOT PREPARED IN
ACCORDANCE WITH GAAP 
  
 Attachment 2 
  

 - 1 - 

 Exhibit E 
 Form of NOTICE OF BORROWING 
  
 [Date] 
  
 Wells Fargo Bank, National Association 
 as Agent for the Lenders party to the 
 Credit Agreement referred to below

 201 Third Street, 8th
Floor 
 San Francisco, California 94103 
 Attn: Agency
Syndication Group 
  
 Ladies and Gentlemen: 
  
 The undersigned, Sigma-Aldrich Corporation, refers to the Credit Agreement,
dated as of February 23, 2005 (as the same may be amended, restated, supplemented or otherwise modified from time to time, the “Credit Agreement”; the terms defined therein being used herein as therein defined), among the undersigned, the
financial institutions party thereto (the “Lenders”), Wells Fargo Bank, National Association, as Administrative Agent for such Lenders, and hereby gives you notice pursuant to Section 2.02 of the Credit Agreement that the undersigned
hereby requests a Borrowing under the Credit Agreement and, in that connection, sets forth below the information relating to such Borrowing, as required by Section 2.02(a) of the Credit Agreement: 
  

	 	(i)	The requested Borrowing Date for the proposed Borrowing (which is a Business Day) is
                    ,         . 

  

	 	(ii)	The aggregate amount of the proposed Borrowing is $            . 

  

	 	(iii)	The type of Loans comprising the proposed Borrowing are [Term] [Revolving] Loans. 

  

	 	(iv)	The type of Loans comprising the proposed Borrowing are [Base Rate] [LIBOR] Loans. The aggregate amount of proposed Base Rate Loans is
$            . The aggregate amount of proposed LIBOR Loans is $            . 

  

	 	(v)	The duration of the Interest Period for each LIBOR Loan made as part of the proposed Borrowing, if applicable, is
             months (which shall be 1, 2, 3, 6, 9 or 12 months). [To be included in the case of a LIBOR Borrowing.] 

  
 The undersigned hereby certifies that the following statements are true on
the date hereof, and will be true on the date of the proposed Borrowing, before and after giving effect thereto and to the application of the proceeds therefrom: 
  

	 	(a)	The representations and warranties contained in Article IV of the Credit Agreement are true and correct as though made on and as of such date 

  
 Exhibit E 
  

 - 1 - 

 (except to the extent such representations and warranties expressly refer to an earlier date, in which
case such representations and warranties are true and correct as of such earlier date); 
  

	 	(b)	No Default or Event of Default has occurred and is continuing, or would result from such proposed Borrowing; and 

  

	 	(c)	The proposed Borrowing will not cause the aggregate principal amount of all outstanding Loans plus the aggregate amount of outstanding Letters of Credit Obligations, to
exceed the combined Commitments of the Lenders. 

  

			
	Very truly yours,
	
	SIGMA-ALDRICH CORPORATION
		
	By:	 	  

	Name:	 	  

	Title:	 	  

		
	By:	 	  

	Name:	 	  

	Title:	 	  

  
 Exhibit E

  

 - 2 - 

 EXHIBIT F 
 FORM OF NOTICE OF CONVERSION/CONTINUATION 
  
 [Date]                                      
       
  
 Wells Fargo Bank, National Association

 as Agent for the Lenders party to the 
 Credit Agreement
referred to below 
 201 Third Street, 8th Floor 
 San Francisco, California 94103 
 Attn:
Agency Syndication Group 
  
 Ladies and Gentlemen: 
  
 The undersigned, Sigma-Aldrich Corporation, refers to the Credit Agreement
(5-Year Facility), dated as of February 23, 2005 (as the same may be amended, restated, supplemented or otherwise modified from time to time, the “Credit Agreement”; the terms defined therein being used herein as therein defined), among
the undersigned, the financial institutions party thereto (the “Lenders”), Wells Fargo Bank, National Association, as Administrative Agent for such Lenders, and hereby gives you notice pursuant to Section 2.02 of the Credit Agreement that
the undersigned hereby requests a [conversion] [continuation] of Loans under the Credit Agreement, and in that connection sets forth below the information relating to such [conversion] [continuation], as required by Section 2.02(b) of the Credit
Agreement: 
  
 (i) The date of the proposed
[conversion] [continuation] is             , 200   (which shall be a Business Day). 
  
 (ii) The aggregate amount of the Loans proposed to be [converted] [continued] is
$            . [Specify which part is to be converted and which part is to be continued, if appropriate.] The type of Loans to be [continued] [converted] are [Base Rate Loans] [LIBOR
Loans]. 
  
 (iii) The amount of the Borrowing
which is to be [converted into] [continued as] a LIBOR Borrowing is $             . The duration of the requested Interest Period applicable thereto is
             months (which shall be 1, 2, 3, 6, 9 or 12 months). 
  
 The undersigned hereby certifies that before and after giving effect to the proposed [conversion][continuation] and to the application of the proceeds
therefrom, no Default or Event of Default has occurred and is continuing, or would result from such proposed [conversion] [continuation]. 
  

			
	Very truly yours,
	
	SIGMA-ALDRICH CORPORATION
		
	By:	 	  

	Name:	 	  

	Title:	 	  

		
	By:	 	  

	Name:	 	  

	Title	 	  

  
 Exhibit G

  

 -1- 

 EXHIBIT G 
  

LENDER ASSUMPTION AGREEMENT 
  
 Dated:                      
  
 Sigma-Aldrich Corporation 
 3050 Spruce Street 
 St. Louis, Missouri 63103 
  
 Attention: Larry D. Roeder 
  
 Wells Fargo Bank, National Association, 
 as Administrative
Agent 
 230 West Wacker Drive 
 Chicago, IL 60606 
  
 Attention: Steven M. Buehler 
  
 Ladies and Gentlemen: 
  
 Reference is made to the Credit Agreement dated as of February 23, 2005 by and among Sigma-Aldrich Corporation, a Delaware corporation (the
“Borrower”), the Lenders from time to time party thereto, Wells Fargo Bank, National Association, as Administrative Agent and Letter of Credit Issuer, Wells Fargo Bank, National Association and Wachovia Capital Markets, LLC as Joint Lead
Arrangers for the Lenders, Wachovia Bank, N.A., as Syndication Agent, and ABN AMRO Bank N.V., The Bank Of Tokyo-Mitsubishi, Ltd., Chicago Branch and U.S. Bank N.A., as Co-Documentation Agents ((as amended or modified, the “Credit
Agreement”), terms defined therein being used herein as therein defined). 
  
 The undersigned (the “Assuming Lender”) proposes to become an Assuming Lender pursuant to Section 2.08 of the Credit Agreement and, in that connection, hereby agrees that it shall become a Lender for
purposes of the Credit Agreement on [applicable Increase Date] and that its Revolving Commitment shall as of such date be $            . 
  
 The undersigned (i) confirms that it has received a copy of the Credit
Agreement, together with copies of the financial statements referred to therein and such other documents and information as it has deemed appropriate to make its own credit analysis and decision to enter into this Lender Assumption Agreement; (ii)
agrees that it will, independently and without reliance upon the Administrative Agent or any other 
  
 Exhibit G 
  

 -2- 

 Lender and based on such documents and information as it shall deem appropriate at the time, continue to make its own
credit decisions in taking or not taking action under the Credit Agreement; (iii) appoints and authorizes the Administrative Agent to take such action as agent on its behalf and to exercise such powers under the Credit Agreement as are delegated to
the Administrative Agent by the terms thereof, together with such powers as are reasonably incidental thereto; (iv) agrees that it will perform in accordance with their terms all of the obligations which by the terms of the Credit Agreement are
required to be performed by it as a Lender, including, without limitation, in connection with its individualized participation interest in all Letters of Credit; (v) agrees that its payment instructions and notice instructions are as set forth in
the attachment to Schedule 1; (vi) confirms that it is an Eligible Lender; and (vii) attaches, if it is not incorporated under the laws of the United States of America or a state thereof, the forms prescribed by the Internal Revenue Services of the
United States required under the Credit Agreement. 
  
 The
Assuming Lender requests that the Borrower deliver to the Administrative Agent (to be promptly delivered to the Assuming Lender) a Revolving Note executed by the Borrower, in each case payable to the order of the Assuming Lender and dated as of the
[Increase Date]. 
  
 The effective date for this Lender Assumption
Agreement shall be [applicable Increase Date]. Upon delivery of this Lender Assumption Agreement to the Borrower and the Administrative Agent, and satisfaction of all conditions imposed under Section 2.08 as of [date specified above], the
undersigned shall be a party to the Credit Agreement and have the rights and obligations of a Lender thereunder. As of [date specified above], the Administrative Agent shall make all payments under the Credit Agreement in respect of the interest
assumed hereby (including, without limitation, all payments of principal, interest and fees) to the Assuming Lender. 
  
 This Lender Assumption Agreement may be executed in counterparts and by different parties hereto in separate counterparts, each of which when so executed
shall be deemed to be an original and all of which taken together shall constitute one and the same agreement. Delivery of an executed counterpart by telecopier shall be effective as delivery of a manually executed counterpart of this Lender
Assumption Agreement. 
  
 Exhibit G 
  

 -3- 

 THIS LENDER ASSUMPTION AGREEMENT SHALL BE GOVERNED BY, AND CONSTRUED IN ACCORDANCE WITH, THE LAWS OF
THE STATE OF ILLINOIS WITHOUT REFERENCE TO THE PROVISIONS THEREOF REGARDING CONFLICTS OF LAW. 
  

			
	Very truly yours,
	
	[NAME OF ASSUMING LENDER]
		
	By:	 	  

	Title:	 	  

  

			
	Acknowledged and Agreed to:
	
	SIGMA-ALDRICH CORPORATION
		
	By:	 	  

	Title:	 	  

  
 WELLS FARGO, NATIONAL ASSOCIATION, as
Administrative Agent 
  

			
	 By:
	 	  

	 Title:
	 	  

  
 Exhibit G 
  

 -4-Amendment No. 3 to the Credit Agreement

 Exhibit 10.1 
  
 AMENDMENT NO. 3 
  
 This AMENDMENT NO. 3 (“AMENDMENT”) is made as of February 16, 2005, by and among DOVER MOTORSPORTS, INC., a Delaware corporation, DOVER
INTERNATIONAL SPEEDWAY, INC., a Delaware corporation, GATEWAY INTERNATIONAL MOTORSPORTS CORPORATION, an Illinois corporation, GATEWAY INTERNATIONAL SERVICES CORPORATION, an Illinois corporation, MEMPHIS INTERNATIONAL MOTORSPORTS CORPORATION, a
Tennessee corporation, M&N SERVICES CORP., a Tennessee corporation, NASHVILLE SPEEDWAY USA, INC., a Tennessee corporation and GRAND PRIX ASSOCIATION OF LONG BEACH, INC., a California corporation (collectively, “BORROWERS”);
MERCANTILE-SAFE DEPOSIT AND TRUST COMPANY, a Maryland banking corporation as agent (“AGENT”); MERCANTILE-SAFE DEPOSIT AND TRUST COMPANY, a Maryland banking corporation in its capacity as issuer of letters of credit (“ISSUING
BANK”); and WILMINGTON TRUST COMPANY, MERCANTILE-SAFE DEPOSIT AND TRUST COMPANY, DELAWARE STERLING BANK, a division of Bank of Lancaster County, NA, WILMINGTON SAVINGS FUND SOCIETY, FSB and PNC BANK, DELAWARE (collectively,
“LENDERS”). 
  
 RECITALS 
  
 The BORROWERS, the AGENT, the ISSUING BANK and the LENDERS are parties to
that certain Credit Agreement executed February 17, 2004 and effective as of February 19, 2004, as previously amended (“CREDIT AGREEMENT”), pursuant to which the LENDERS and the ISSUING BANK are providing to the BORROWERS certain credit
facilities. 
  
 The parties hereto have agreed to amend a certain
provision of the CREDIT AGREEMENT and are entering into this AMENDMENT in order to accomplish such amendment. 
  
 NOW, THEREFORE, in consideration of the premises, and other good and valuable consideration, the receipt and adequacy of which are hereby acknowledged,
the parties agree as follows: 
  
 Section 1. Recitals. The
parties acknowledge the accuracy of the above recitals and hereby incorporate the recitals into this AMENDMENT. 
  
 Section 2. Amendment to Credit Agreement. Section 5.17 of the CREDIT AGREEMENT is hereby amended by deleting its present language in its entirety
and substituting in lieu thereof the following: 
  
 Section 5.17. Fixed Charge Coverage Ratio. The BORROWERS shall maintain a FIXED CHARGE COVERAGE RATIO of not less than: 
  
 (a) 1.0 to 1.0 for the four fiscal quarter period ending on June 30, 2005; and (b) 1.75 to 1.0 for each four fiscal quarter period ending on the last day
of each fiscal quarter other than June 30, 2005. 

 Section 3. Other Terms. Except as specifically modified herein, all other terms and provisions of
the CREDIT AGREEMENT and all other documents evidencing, securing or otherwise documenting the terms and provisions of the credit facilities being provided by the LENDERS and the ISSUING BANK to the BORROWERS remain in full force and effect and are
hereby ratified and confirmed. 
  
 Section 4. Choice of
Law. The laws of the State of Maryland (excluding, however, conflict of law principals) shall govern and be applied to determine all issues relating to this AMENDMENT and the rights and obligations of the parties hereto, including the validity,
construction, interpretation and enforceability of this AMENDMENT. 
  
 Section 5. Delivery by Telecopier. This AMENDMENT may be delivered by telecopier and a facsimile of any party’s signature hereto shall constitute an original signature for all purposes. 
  
 Section 6. Counterparts. This AMENDMENT may be executed in
counterparts each of which shall be binding upon the signatories but all of which shall constitute one and the same agreement. 
  
 IN WITNESS WHEREOF, the parties have executed this AMENDMENT with the specific intention of creating a document under seal. 
  

					
	BORROWERS:
	
	DOVER MOTORSPORTS, INC.,
	 A Delaware Corporation

			
	 By:
	 	 /s/ Thomas G. Wintermantel

	 	 (SEAL)

	 Name:
	 	 Thomas G. Wintermantel
	 	 
	 Title:
	 	 Treasurer
	 	 
	
	DOVER INTERNATIONAL SPEEDWAY, INC.,
	 A Delaware Corporation

			
	 By:
	 	 /s/ Thomas G. Wintermantel

	 	 (SEAL)

	 Name:
	 	 Thomas G. Wintermantel
	 	 
	 Title:
	 	 Treasurer
	 	 

					
	 GATEWAY INTERNATIONAL MOTORSPORTS
 CORPORATION, An Illinois Corporation

			
	 By:
	 	 /s/ Patrick J. Bagley

	 	 (SEAL)

	 Name:
	 	 Patrick J. Bagley
	 	 
	 Title:
	 	 Sr. VP of Finance and CFO
	 	 
	
	 GATEWAY INTERNATIONAL SERVICES
 CORPORATION, An Illinois Corporation

			
	 By:
	 	 /s/ Tony R. Evans

	 	 (SEAL)

	 Name:
	 	 Tony R. Evans
	 	 
	 Title:
	 	 Treasurer and Secretary
	 	 
	
	 MEMPHIS INTERNATIONAL MOTORSPORTS
 CORPORATION, A Tennessee Corporation

			
	 By:
	 	 /s/ Patrick J. Bagley

	 	 (SEAL)

	 Name:
	 	 Patrick J. Bagley
	 	 
	 Title:
	 	 Sr. VP of Finance and CFO
	 	 
	
	M&N SERVICES CORP.,
	 A Tennessee Corporation

			
	 By:
	 	 /s/ Tony R. Evans

	 	 (SEAL)

	 Name:
	 	 Tony R. Evans
	 	 
	 Title:
	 	 Treasurer and Secretary
	 	 
	
	 NASHVILLE SPEEDWAY USA, INC.,
 A Tennessee Corporation

			
	 By:
	 	 /s/ Patrick J. Bagley

	 	 (SEAL)

	 Name:
	 	 Patrick J. Bagley
	 	 
	 Title:
	 	 Sr. VP of Finance and CFO
	 	 

					
	 GRAND PRIX ASSOCIATION OF LONG
 BEACH, INC., A California Corporation

			
	 By:
	 	 /s/ Patrick J. Bagley

	 	 (SEAL)

	 Name:
	 	 Patrick J. Bagley
	 	 
	 Title:
	 	 Sr. VP of Finance and CFO
	 	 
	
	AGENT:
	
	 MERCANTILE-SAFE DEPOSIT AND TRUST
 COMPANY, A Maryland Banking Corporation

			
	 By:
	 	 /s/ C. Douglas Sawyer, III

	 	 (SEAL)

	 Name:
	 	 C. Douglas Sawyer, III
	 	 
	 Title:
	 	 Senior Vice President
	 	 
	
	LENDERS:
	
	WILMINGTON TRUST COMPANY
			
	 By:
	 	 /s/ Michael B. Gast

	 	 (SEAL)

	 Name:
	 	 Michael B. Gast
	 	 
	 Title:
	 	 Vice President
	 	 
	
	 MERCANTILE-SAFE DEPOSIT AND
     TRUST COMPANY

			
	 By:
	 	 /s/ C. Douglas Sawyer, III

	 	 (SEAL)

	 Name:
	 	 C. Douglas Sawyer, III
	 	 
	 Title:
	 	 Senior Vice President
	 	 
	
	 DELAWARE STERLING BANK,
 A Division of Bank of Lancaster County, NA

			
	 By:
	 	 /s/ David Paul Kenney

	 	 (SEAL)

	 Name:
	 	 David Paul Kenney
	 	 
	 Title:
	 	 Senior Vice President
	 	 

					
	WILMINGTON SAVINGS FUND SOCIETY, FSB
			
	 By:
	 	 /s/ M. Scott Baylis

	 	 (SEAL)

	 Name:
	 	 M. Scott Baylis
	 	 
	 Title:
	 	 Managing Vice President
	 	 
	
	PNC BANK, DELAWARE
			
	 By:
	 	 /s/ Warren C. Engle

	 	 (SEAL)

	 Name:
	 	 Warren C. Engle
	 	 
	 Title:
	 	 Senior Vice President
	 	 
	
	ISSUING BANK:
	
	 MERCANTILE-SAFE DEPOSIT AND
     TRUST COMPANY

			
	 By:
	 	 /s/ C. Douglas Sawyer, III

	 	 (SEAL)

	 Name:
	 	 C. Douglas Sawyer, III
	 	 
	 Title:
	 	 Senior Vice President

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