Document:

Guaranty of Renewable Energy Group, Inc

 Exhibit 10.4 
 GUARANTY 
 In consideration of and in order to induce USRG HOLDCO
IX, LLC, a Delaware limited liability company (“Lender”), to extend financial accommodations to REG ALBERT LEA, LLC, an Iowa limited liability company (“Borrower”), pursuant to that certain Loan Agreement
of even date herewith by and between Lender, Borrower and USRG Management Company, LLC (collectively, the “Loan Agreement”), the undersigned (“Guarantor”), hereby: 

1. Agrees that capitalized terms used and not otherwise defined in this Guaranty shall have the meanings attributed to such terms in the
Loan Agreement. 
 2. Unconditionally and absolutely guarantees to Lender (i) the full and prompt payment, when due,
whether at the Maturity Date or upon acceleration of maturity pursuant to the provisions of the Loan Documents, of the principal amount and accrued interest on the Note; (ii) all additional Loan Obligations of Borrower; and (iii) the full
and prompt payment of any and all costs and expenses of and incidental to the enforcement of this Guaranty, including, without limitation, attorneys’ fees (collectively, the “Guarantor Obligations”). 

3. Agrees that Lender may, subject to the foregoing, demand payment from Guarantor of any of the Guarantor Obligations, when or at any
time after the same are due, and Guarantor shall immediately pay the same to Lender, whether or not Lender has (1) accelerated payment of the Loan Obligations; or (2) commenced repossession of, or foreclosure of any security interest,
mortgage or other lien in, any or all of the collateral securing the Loan Obligations; or (3) otherwise exercised its rights and remedies hereunder or under the Loan Obligations, the documents related thereto or applicable law. 

4. Waives (a) presentment, demand, notice of nonpayment, protest, and notice of protest and dishonor on the Loan Obligations;
(b) notice of acceptance of this Guaranty by Lender; and (c) notice of the creation or incurrence of the Loan Obligations by Borrower. 
 5. Agrees that Lender may, from time to time, without notice to Guarantor, which notice is hereby waived by Guarantor, extend, modify, renew or compromise the Loan Obligations, in whole or in part,
without releasing, extinguishing or affecting in any manner whatsoever the liability of Guarantor hereunder, the foregoing acts being hereby consented to by Guarantor. 
 6. Agrees that Lender shall not be required to first resort for payment to Borrower or any other person, corporation or entity, or their properties or estate, or any other right or remedy whatsoever,
prior to enforcing this Guaranty. 
 7. Agrees that this Guaranty shall be construed as a continuing, absolute and unconditional guaranty
without regard to (a) the validity, regularity or enforceability of the Loan Obligations or the disaffirmance thereof in any insolvency or bankruptcy proceeding relating to Borrower; or (b) any event or any conduct or action of Borrower or
Lender or any other party which might otherwise constitute a legal or equitable discharge of a surety or guarantor but for this provision. 

 8. Agrees that this Guaranty shall remain in full force and effect and be binding upon
Guarantor until the earlier of the date the Loan Obligations are paid in full or the date Guarantor has fully performed its obligations to Lender under this Guaranty. 
 9. Agrees that Lender is expressly authorized to forward or deliver any or all collateral and security which may, at any time, be placed with it by Borrower, Guarantor or any other person, directly to
Borrower for collection and remittance or for credit, or to collect the same in any other manner and to renew, extend, compromise, exchange, release, surrender or modify the installments of, any or all of such collateral and security with or without
consideration and without notice to Guarantor and without in any manner affecting the absolute liability of Guarantor hereunder; and that, except as otherwise provided herein, the liability of Guarantor hereunder shall not be affected or impaired by
any failure, neglect or omission on the part of Lender to realize upon the Loan Obligations, or upon any collateral or security therefore, nor by the taking by Lender of any other guaranty or guaranties to secure the Loan Obligations or any other
indebtedness of Borrower to Lender, nor by the taking by Lender of collateral or security of any kind nor by any act or failure to act whatsoever which, but for this provision, might or could in law or in equity act to release or reduce
Guarantor’s liability hereunder. 
 10. Agrees that notwithstanding any payment or payments made by Guarantor hereunder or
any setoff or application of funds of Guarantor by Lender, Guarantor shall not be entitled to be subrogated to any of the rights of Lender against Borrower or any other guarantor or any collateral security or guaranty or right of offset held by
Lender for the payment of the Loan Obligations, nor shall Guarantor seek or be entitled to seek any contribution or reimbursement from Borrower or any other guarantor in respect of payments made by Guarantor hereunder, until all amounts owing to
Lender by Borrower and on account of the Loan Obligations are paid in full. Notwithstanding any of the foregoing, to the extent (a) any right of subrogation which Guarantor may have pursuant to this Guaranty or otherwise, or (b) any right
of reimbursement or contribution or similar right against Borrower, any property of Borrower or any other guarantor of any of the Loan Obligations would result in Guarantor being “creditors” of or the holders of a “claim” against
Borrower within the meaning of Title 11 of the United States Bankruptcy Code as now in effect or hereafter amended, or any comparable provision of any successor statute, Guarantor hereby irrevocably waives such right of subrogation, reimbursement or
contribution. 
 11. Agrees that the liability of Guarantor hereunder shall not be affected or impaired by the existence or
creation from time to time, with or without notice to Guarantor, which notice is hereby waived, of indebtedness from Borrower to Lender in addition to the indebtedness evidenced by the Note; the creation or existence of such additional indebtedness
being hereby consented to by Guarantor. 
 12. Agrees that the possession of this instrument of guaranty by Lender shall be
conclusive evidence of due execution and delivery hereof by Guarantor. 
 13. Agrees that this Guaranty shall be binding upon
the legal representative, successors and assigns of Guarantor, and shall inure to the benefit of Lender and its successors, assigns and legal representative; that notwithstanding the foregoing, Guarantor shall have no

  
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right to assign or otherwise transfer their rights and obligations under this Guaranty to any third party without the prior written consent of Lender; and that any such assignment or transfer
shall not release or affect the liability of Guarantor hereunder in any manner whatsoever. 
 14. Agrees that Guarantor may be
joined in any action or proceeding commenced against Borrower in connection with or based upon the Loan Obligations and recovery may be had against Guarantor, to the extent of the Guarantor Obligations, in any such action or proceeding or in any
independent action or proceeding against Guarantor should Borrower fail to duly and punctually pay the Guarantor Obligations outstanding without any requirement that Lender first assert, prosecute or exhaust any remedy or claim against Borrower.

 15. Agrees that upon the occurrence at any time of an Event of Default, Lender shall have the right to set off any and all
amounts due hereunder by Guarantor to Lender against any indebtedness or obligation of Lender to Guarantor. 
 16. Agrees that
Guarantor shall be liable to Lender for any deficiency remaining after foreclosure of any mortgage on real estate or any security interest in personal property granted by Borrower, Guarantor or any third party to Lender to secure repayment of the
Loan Obligations and the subsequent sale by Lender of the property subject thereto to a third party (whether at a foreclosure sale or at a sale thereafter by Lender in the event Lender purchases said property at the foreclosure sale) notwithstanding
any provision of applicable law which may prevent Lender from obtaining a deficiency judgment against, or otherwise collecting a deficiency from, Borrower. 
 17. Agrees that this Guaranty shall be deemed a contract made under and pursuant to the laws of the State of New York and shall be governed by and construed under the laws of such state; and that,
wherever possible, each provision of this Guaranty shall be interpreted in such a manner as to be effective and valid under applicable law, but if any provisions of this Guaranty shall be prohibited by or invalid under applicable law, such provision
shall be ineffective only to the extent of such prohibition or invalidity without invalidating the remainder of such provision or the remaining provisions of the Guaranty. 
 18. Agrees that no failure on the part of Lender to exercise, and no delay in exercising, any right or remedy hereunder shall operate as or constitute a waiver thereof; nor shall any single or partial
exercise of any right or remedy hereunder preclude any other or further exercise thereof or the exercise of any other right or remedy granted hereby or by any related document or by law. 

19. Waives any and all claims against Lender and defenses to performance and payment hereunder relating in any way, directly or
indirectly, to the performance of Lender’s obligations or exercise of any of its rights under the Note and the Loan Documents. 
 20. Warrants and represents to Lender as follows: 
  

	 	a.	 Enforceability. This Guaranty constitutes the legal, valid and binding obligation of Guarantor enforceable in accordance with its terms
(subject, 

  
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as to enforceability, to limitations resulting from bankruptcy, insolvency or other similar laws affecting creditors’ rights generally). 

 

	 	b.	Litigation. There is no action, suit or proceeding pending or, to the knowledge of Guarantor, threatened against or affecting Guarantor which, if adversely
determined, would have a material adverse effect on the condition (financial or otherwise), property or assets of Guarantor, or which would question the validity of this Guaranty or any instrument, document or other agreement related hereto or
required hereby, or impair the ability of Guarantor to perform their obligations hereunder or thereunder. 

  

	 	c.	Default. Guarantor is not in default of a material provision under any material agreement, instrument, decree or order to which it is a party or by which it or
its property is bound or affected. 

  

	 	d.	Consents. No consent, approval, order or authorization, registration, declaration or filing with, or notice to, any governmental authority or any third party is
required in connection with the execution and delivery of this Guaranty or any of the agreements or instruments herein mentioned to which Guarantor is a party or the carrying out or performance of any of the transactions required or contemplated
hereby or thereby or, if required, such consent, approval, order or authorization has been obtained or such registration, declaration or filing has been accomplished or such notice has been given prior to the date hereof. 

21. Agrees that (a) Guarantor will indirectly benefit by and from the making of the Loan; (b) Guarantor has received legal and
adequate consideration for the execution of this Guaranty and has executed and delivered this Guaranty to Lender in good faith in exchange for reasonably equivalent value; (c) Guarantor is not presently insolvent and will not be rendered
insolvent by virtue of the execution and delivery of this Guaranty; (d) Guarantor has not executed or delivered this Guaranty with actual intent to hinder, delay or defraud Guarantor’s creditors; and (e) Lender has agreed to make such
loan in reliance upon this Guaranty. 
 22. Agrees that if, at any time, all or any part of any payment previously applied by
Lender to any of the Loan Obligations must be returned by Lender for any reason, whether by court order, administrative order or settlement, Guarantor shall remain liable for the full amount of Loan Obligations returned as if said amount had never
been received by Lender, notwithstanding any term of this Guaranty or the cancellation or return of any note or other agreement evidencing the Loan Obligations. 
 (A) Notices. Unless otherwise expressly specified or permitted by the terms hereof, all communications and notices provided for herein shall be in writing or by facsimile, and any such notice shall
become effective (i) upon personal delivery thereof, including, without limitation, by overnight mail or courier service, (ii) in the case of notice by United States mail, certified or registered, postage prepaid, return receipt requested,
upon receipt thereof, or (iii) in 

  
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the case of notice by facsimile, upon confirmation of receipt thereof, provided such transmission is promptly further confirmed by any of the methods set forth in clauses (i) or
(ii) above, in each case addressed to Guarantor at its address set forth below or at such other address as Guarantor may from time to time designate by written notice to the other: 

 

			
	 If to Guarantor:
	  	Renewable Energy Group, Inc.
		  	416 S. Bell Ave., P.O. Box 888
		  	Ames, Iowa 50010
		  	Attn: President
		  	Facsimile: (515) 239-8009
		
	 With a copy to:
	  	Wilcox, Polking, Gerken,
		  	Schwarzkopf & Copeland, P.C.
		  	115 E. Lincolnway, Suite 200
		  	Jefferson, Iowa 50129-2149
		  	Attn: John Gerken
		  	Facsimile: (515) 386-8531

 23. Default. A default shall be deemed to have occurred hereunder (“Default”) if:
(a) Guarantor shall fail to perform or observe any covenant or obligation to be performed by it hereunder upon ten (10) days’ written notice by Lender of such failure; (b) a material inaccuracy exists in any representation or
warranty made by Guarantor hereunder; or (c) Guarantor generally fails to pay its debts as they become due or its admission in writing of its inability to pay the same, or the commencement of any bankruptcy, insolvency, receivership or similar
proceeding by or against Guarantor or any of its properties or business (unless, if involuntary, the proceeding is dismissed within sixty (60) days of the filing thereof) or the rejection of this Guaranty in any such proceeding. 

24. Remedies. Upon a Default hereunder, Lender may, at its option, declare this Guaranty to be in default by written notice to
Guarantor (without election of remedies), and at any time thereafter, may do any one or more of the following, all of which are hereby authorized by Guarantor: 
  

	 	a.	declare the Loan Documents to be in default and thereafter sue for and recover all damages and all other sums otherwise recoverable from Borrower or Guarantor
thereunder; and/or 

  

	 	b.	pursue any and all legal remedies available to Lender under this Guaranty as a result of such Default. 

[Signature Page Follows] 

  
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 Dated this 4th day of August, 2011. 

 

	
	GUARANTOR:
	
	RENEWABLE ENERGY GROUP, INC.
	
	 _/s/ Daniel J. Oh

	By: Daniel J. Oh
	  Its: President

 [SIGNATURE PAGE TO GUARANTY] 

  
 62011 Stock Incentive Plan

 Exhibit 4.3 
 ACCELRYS, INC. 
 2011 STOCK INCENTIVE PLAN 

1. Purposes of the Plan. The purpose of this Plan is to provide motivation to selected Employees, Directors and Consultants to put
forth maximum efforts toward the continued growth, profitability, and success of the Company by providing incentives to such Employees, Directors and Consultants through the ownership and performance of Common Stock, and to align the interests of
such individuals with those of the Company’s stockholders. 
 2. Definitions. The following definitions shall apply
as used herein and in the individual Award Agreements except as defined otherwise in an individual Award Agreement. In the event a term is separately defined in an individual Award Agreement, such definition shall supercede the definition contained
in this Section 2. 
 (a) “Administrator” means the Board or any of the Committees appointed to administer
the Plan. 
 (b) “Affiliate” and “Associate” shall have the respective meanings ascribed to
such terms in Rule 12b-2 promulgated under the Exchange Act. 
 (c) “Applicable Laws” means the legal
requirements relating to the Plan and the Awards under applicable provisions of federal securities laws, state corporate and securities laws, the Code, the rules of any applicable stock exchange or national market system, and the rules of any
non-U.S. jurisdiction applicable to Awards granted to residents therein. 
 (d) “Assumed” means that pursuant
to a Corporate Transaction either (i) the Award is expressly affirmed by the Company or (ii) the contractual obligations represented by the Award are expressly assumed (and not simply by operation of law) by the successor entity or its
Parent in connection with the Corporate Transaction with appropriate adjustments to the number and type of securities of the successor entity or its Parent subject to the Award and the exercise or purchase price thereof which at least preserves the
compensation element of the Award existing at the time of the Corporate Transaction as determined in accordance with the instruments evidencing the agreement to assume the Award. 

(e) “Award” means the grant of an Option, SAR, Restricted Stock, Restricted Stock Unit, cash or other right or benefit
under the Plan. 
 (f) “Award Agreement” means the written agreement evidencing the grant of an Award executed
by the Company and the Grantee, including any amendments thereto. 
 (g) “Board” means the Board of Directors
of the Company. 
 (h) “Cause” means, with respect to the termination by the Company or a Related Entity of the
Grantee’s Continuous Service, that such termination is for “Cause” as such term (or word of like import) is expressly defined in a then-effective written agreement between the Grantee and the Company or such Related Entity, or in the
absence of such then-effective written agreement and definition, is based on, in the determination of the Administrator, the 

  
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Grantee’s: (i) performance of any act or failure to perform any act in bad faith and to the detriment of the Company or a Related Entity; (ii) dishonesty, intentional misconduct or
material breach of any agreement with the Company or a Related Entity; or (iii) commission of a crime involving dishonesty, breach of trust, or physical or emotional harm to any person; provided, however, that with regard to any agreement that
defines “Cause” on the occurrence of or in connection with a Corporate Transaction or a Change in Control, such definition of “Cause” shall not apply until a Corporate Transaction or a Change in Control actually occurs.

 (i) “Change in Control” means a change in ownership or control of the Company effected through either of the
following transactions: 
 (i) the direct or indirect acquisition by any person or related group of persons (other than an
acquisition from or by the Company or by a Company-sponsored employee benefit plan or by a person that directly or indirectly controls, is controlled by, or is under common control with, the Company) of beneficial ownership (within the meaning of
Rule 13d-3 of the Exchange Act) of securities possessing more than fifty percent (50%) of the total combined voting power of the Company’s outstanding securities pursuant to a tender or exchange offer made directly to the Company’s
stockholders which a majority of the Continuing Directors who are not Affiliates or Associates of the offeror do not recommend such stockholders accept, or 
 (ii) a change in the composition of the Board over a period of twelve (12) months or less such that a majority of the Board members (rounded up to the next whole number) ceases, by reason of one or
more contested elections for Board membership, to be comprised of individuals who are Continuing Directors. 
 (j)
“Code” means the Internal Revenue Code of 1986, as amended. 
 (k) “Committee” means any
committee composed of members of the Board appointed by the Board to administer the Plan. 
 (l) “Common Stock”
means the common stock of the Company. 
 (m) “Company” means Accelrys, Inc., a Delaware corporation, or any
successor entity that adopts the Plan in connection with a Corporate Transaction. 
 (n) “Consultant” means any
person (other than an Employee or a Director, solely with respect to rendering services in such person’s capacity as a Director) who is engaged by the Company or any Related Entity to render consulting or advisory services to the Company or
such Related Entity. 
 (o) “Continuing Directors” means members of the Board who either (i) have been
Board members continuously for a period of at least twelve (12) months or (ii) have been Board members for less than twelve (12) months and were elected or nominated for election as Board members by at least a majority of the Board
members described in clause (i) who were still in office at the time such election or nomination was approved by the Board. 

  
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 (p) “Continuous Service” means that the provision of services to the
Company or a Related Entity in any capacity of Employee, Director or Consultant is not interrupted or terminated. In jurisdictions requiring notice in advance of an effective termination as an Employee, Director or Consultant, Continuous Service
shall be deemed terminated upon the actual cessation of providing services to the Company or a Related Entity notwithstanding any required notice period that must be fulfilled before a termination as an Employee, Director or Consultant can be
effective under Applicable Laws. A Grantee’s Continuous Service shall be deemed to have terminated either upon an actual termination of Continuous Service or upon the entity for which the Grantee provides services ceasing to be a Related
Entity. Continuous Service shall not be considered interrupted in the case of (i) any approved leave of absence, (ii) transfers among the Company, any Related Entity, or any successor, in any capacity of Employee, Director or Consultant,
or (iii) any change in status as long as the individual remains in the service of the Company or a Related Entity in any capacity of Employee, Director or Consultant (except as otherwise provided in the Award Agreement). Notwithstanding the
foregoing, except as otherwise determined by the Administrator, in the event of any spin-off of a Related Entity, service as an Employee, Director or Consultant for such Related Entity following such spin-off shall be deemed to be Continuous Service
for purposes of the Plan and any Award under the Plan. An approved leave of absence shall include sick leave, military leave, or any other authorized personal leave. For purposes of each Incentive Stock Option granted under the Plan, if such leave
exceeds three (3) months, and reemployment upon expiration of such leave is not guaranteed by statute or contract, then the Incentive Stock Option shall be treated as a Non-Qualified Stock Option on the day three (3) months and one
(1) day following the expiration of such three (3) month period. 
 (q) “Corporate Transaction” means
any of the following transactions, provided, however, that the Administrator shall determine under parts (iv) and (v) whether multiple transactions are related, and its determination shall be final, binding and conclusive: 

(i) a merger or consolidation in which the Company is not the surviving entity, except for a transaction the principal purpose of which
is to change the state in which the Company is incorporated; 
 (ii) the sale, transfer or other disposition of all or
substantially all of the assets of the Company; 
 (iii) the complete liquidation or dissolution of the Company; 

(iv) any reverse merger or series of related transactions culminating in a reverse merger (including, but not limited to, a tender offer
followed by a reverse merger) in which the Company is the surviving entity but (A) the shares of Common Stock outstanding immediately prior to such merger are converted or exchanged by virtue of the merger into other property, whether in the
form of securities, cash or otherwise, or (B) in which securities possessing more than forty percent (40%) of the total combined voting power of the Company’s outstanding securities are transferred to a person or persons different
from those who held such securities immediately prior to such merger or the initial transaction culminating in such merger; or 

  
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 (v) acquisition in a single or series of related transactions by any person or related
group of persons (other than the Company or by a Company-sponsored employee benefit plan) of beneficial ownership (within the meaning of Rule 13d-3 of the Exchange Act) of securities possessing more than fifty percent (50%) of the total
combined voting power of the Company’s outstanding securities but excluding any such transaction or series of related transactions that the Administrator determines shall not be a Corporate Transaction. 

(r) “Covered Employee” means an Employee who is a “covered employee” under Section 162(m)(3) of the Code.

 (s) “Director” means a member of the Board or the board of directors of any Related Entity. 

(t) “Disability” means as defined under the long-term disability policy of the Company or the Related Entity to which
the Grantee provides services regardless of whether the Grantee is covered by such policy. If the Company or the Related Entity to which the Grantee provides service does not have a long-term disability plan in place, “Disability” means
that a Grantee is unable to carry out the responsibilities and functions of the position held by the Grantee by reason of any medically determinable physical or mental impairment for a period of not less than ninety (90) consecutive days. A
Grantee will not be considered to have incurred a Disability unless he or she furnishes proof of such impairment sufficient to satisfy the Administrator in its discretion. 
 (u) “Employee” means any person, including an Officer or Director, who is in the employ of the Company or any Related Entity, subject to the control and direction of the Company or any
Related Entity as to both the work to be performed and the manner and method of performance. The payment of a director’s fee by the Company or a Related Entity shall not be sufficient to constitute “employment” by the Company.

 (v) “Exchange Act” means the Securities Exchange Act of 1934, as amended. 

(w) “Fair Market Value” means, as of any date, the value of Common Stock determined as follows: 

(i) If the Common Stock is listed on one or more established stock exchanges or national market systems, including without limitation
The NASDAQ Global Select Market, The NASDAQ Global Market or The NASDAQ Capital Market of The NASDAQ Stock Market LLC, its Fair Market Value shall be the closing sales price for such stock (or the closing bid, if no sales were reported) as quoted on
the principal exchange or system on which the Common Stock is listed (as determined by the Administrator) on the date of determination (or, if no closing sales price or closing bid was reported on that date, as applicable, on the last trading date
such closing sales price or closing bid was reported), as reported in The Wall Street Journal or such other source as the Administrator deems reliable; 
 (ii) If the Common Stock is regularly quoted on an automated quotation system (including the OTC Bulletin Board) or by a recognized securities dealer, its Fair Market Value shall be the closing sales
price for such stock as quoted on such system or by 

  
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such securities dealer on the date of determination, but if selling prices are not reported, the Fair Market Value of a share of Common Stock shall be the mean between the high bid and low asked
prices for the Common Stock on the date of determination (or, if no such prices were reported on that date, on the last date such prices were reported), as reported in The Wall Street Journal or such other source as the Administrator deems reliable;
or 
 (iii) In the absence of an established market for the Common Stock of the type described in (i) and (ii), above, the
Fair Market Value thereof shall be determined by the Administrator in good faith. 
 (x) “Grantee” means an
Employee, Director or Consultant who receives an Award under the Plan. 
 (y) “Incentive Stock Option” means an
Option intended to qualify as an incentive stock option within the meaning of Section 422 of the Code. 
 (z)
“Non-Qualified Stock Option” means an Option not intended to qualify as an Incentive Stock Option. 
 (aa)
“Officer” means a person who is an officer of the Company or a Related Entity within the meaning of Section 16 of the Exchange Act and the rules and regulations promulgated thereunder. 

(bb) “Option” means an option to purchase Shares pursuant to an Award Agreement granted under the Plan. 

(cc) “Parent” means a “parent corporation”, whether now or hereafter existing, as defined in
Section 424(e) of the Code. 
 (dd) “Performance-Based Compensation” means compensation qualifying as
“performance-based compensation” under Section 162(m) of the Code. 
 (ee) “Plan” means this
2011 Stock Incentive Plan. 
 (ff) “Related Entity” means any Parent or Subsidiary of the Company. 

(gg) “Replaced” means that pursuant to a Corporate Transaction the Award is replaced with a comparable stock award or a
cash incentive program of the Company, the successor entity (if applicable) or Parent of either of them which preserves the compensation element of such Award existing at the time of the Corporate Transaction and provides for subsequent payout in
accordance with the same (or a more favorable) vesting schedule applicable to such Award. The determination of Award comparability shall be made by the Administrator and its determination shall be final, binding and conclusive. 

(hh) “Restricted Stock” means Shares issued under the Plan to the Grantee for such consideration, if any, and subject to
such restrictions on transfer, rights of first refusal, repurchase provisions, forfeiture provisions, and other terms and conditions as established by the Administrator. 

  
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 (ii) “Restricted Stock Units” means an Award which may be earned in whole
or in part upon the passage of time or the attainment of performance criteria established by the Administrator and which may be settled for cash, Shares or other securities or a combination of cash, Shares or other securities as established by the
Administrator. 
 (jj) “Rule 16b-3” means Rule 16b-3 promulgated under the Exchange Act or any successor
thereto. 
 (kk) “SAR” means a stock appreciation right entitling the Grantee to Shares or cash compensation,
as established by the Administrator, measured by appreciation in the value of Common Stock. 
 (ll) “Section 409A”
means Section 409A of the Code. 
 (mm) “Share” means a share of the Common Stock. 

(nn) “Subsidiary” means a “subsidiary corporation,” whether now or hereafter existing, as defined in
Section 424(f) of the Code. 
 3. Stock Subject to the Plan. 

(a) Maximum Number of Shares and Other Limits. Subject to the provisions of Section 11, below, the maximum aggregate number
of Shares (including Incentive Stock Options) which may be issued pursuant to all Awards is seventeen million seven hundred fifty thousand (17,750,000) Shares, (i) less (x) that number of shares of Common Stock subject to a stock
option or stock appreciation right granted after May 31, 2011 under the Company’s Amended and Restated 2004 Stock Incentive Plan, as amended (the “2004 Plan”), or the 2007 Stock Incentive Plan of Symyx Technologies, Inc,
as amended, which plan was assumed by the Company on August 3, 2010 in accordance with NASDAQ Rule 5635 (the “2007 Plan” and, together with the 2004 Plan, the “Prior Plans”) and (y) 2.22 shares of Common
Stock for every one share of Common Stock that was subject to an award other than a stock option or stock appreciation right granted after May 31, 2011 under the Prior Plans, and (ii) plus (x) that number of shares of Common Stock
subject to a stock option or stock appreciation right, that in each case would, at any time after May 31, 2011, otherwise return to the available pool of unissued shares reserved for awards under any Prior Plan (ignoring the termination or
expiration of such plans for the purpose of determining the number of shares available under the plan) and (y) 2.22 shares of Common Stock for every one share of Common Stock that was subject to an award other than a stock option or stock
appreciation right, that in each case would, at any time after May 31, 2011, otherwise return to the available pool of unissued shares reserved for awards under any Prior Plan (ignoring the termination or expiration of such plans for the
purpose of determining the number of shares available under the plan); provided, however, that the maximum aggregate number of shares that may be issued pursuant to Incentive Stock Options is seventeen million seven hundred fifty thousand
(17,750,000) Shares. Notwithstanding the foregoing, any Shares issued in connection with Awards other than SARs and Options shall be counted against the limit set forth herein as two and twenty-two hundredths (2.22) Shares for every one
(1) Share issued in connection with such Award (and shall be counted as two and twenty-two hundredths (2.22) Shares for one (1) Share returned or deemed not have been issued from the Plan pursuant to

  
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Section 3(b) below in connection with Awards other than Options and SARs). For example, a grant of a restricted stock award for 1,000 shares would count as 2,220 shares against the reserve,
and if returned to the Plan would count as 2,220 shares returned to the Plan. The Shares to be issued pursuant to Awards may be authorized, but unissued, or reacquired Common Stock. 

(b) Shares Available for Future Issuance. Any Shares covered by an Award (or portion of an Award) which is forfeited, canceled or
expires (whether voluntarily or involuntarily) or issued as substitution awards pursuant to Section 6(d) below, shall be deemed not to have been issued for purposes of determining the maximum aggregate number of Shares which may be issued under
the Plan. Shares that actually have been issued under the Plan pursuant to an Award shall not be returned to the Plan and shall not become available for future issuance under the Plan, except that if unvested Shares are forfeited, or repurchased by
the Company at the lower of their original purchase price or their Fair Market Value at the time of repurchase, such Shares shall become available for future grant under the Plan. Notwithstanding anything to the contrary contained herein:
(i) Shares tendered or withheld in payment of an Option exercise price shall not be returned to the Plan and shall not become available for future issuance under the Plan; (ii) Shares withheld by the Company to satisfy any tax withholding
obligation shall not be returned to the Plan and shall not become available for future issuance under the Plan; and (iii) all Shares covered by the portion of an SAR that is exercised (whether or not Shares are actually issued to the Grantee
upon exercise of the SAR) shall be considered issued pursuant to the Plan. 
 4. Administration of the Plan. 

(a) Plan Administrator. 
 (i) Administration with Respect to Directors and Officers. With respect to grants of Awards to Directors or Employees who are also Officers or Directors of the Company, the Plan shall be
administered by (A) the Board or (B) a Committee designated by the Board, which Committee shall be constituted in such a manner as to satisfy Applicable Laws and to permit such grants and related transactions under the Plan to be exempt
from Section 16(b) of the Exchange Act in accordance with Rule 16b-3. Once appointed, such Committee shall continue to serve in its designated capacity until otherwise directed by the Board. 

(ii) Administration With Respect to Consultants and Other Employees. With respect to grants of Awards to Employees or Consultants
who are neither Directors nor Officers of the Company, the Plan shall be administered by (A) the Board or (B) a Committee designated by the Board, which Committee shall be constituted in such a manner as to satisfy Applicable Laws. Once
appointed, such Committee shall continue to serve in its designated capacity until otherwise directed by the Board. The Board may authorize one or more Officers to grant such Awards and may limit such authority as the Board determines from time to
time. 
 (iii) Administration With Respect to Covered Employees. Notwithstanding the foregoing, grants of Awards to any
Covered Employee intended to qualify as Performance-Based Compensation shall be made only by a Committee (or subcommittee of a Committee) which is comprised solely of two or more Directors eligible to serve on a committee making Awards qualifying as
Performance-Based Compensation. In the case of such Awards granted to Covered Employees, references to the “Administrator” or to a “Committee” shall be deemed to be references to such Committee or subcommittee. 

  
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 (iv) Administration Errors. In the event an Award is granted in a manner
inconsistent with the provisions of this subsection (a), such Award shall be presumptively valid as of its grant date to the extent permitted by Applicable Laws. 
 (b) Powers of the Administrator. Subject to Applicable Laws and the provisions of the Plan (including any other powers given to the Administrator hereunder ), and except as otherwise provided by
the Board, the Administrator shall have the authority, in its discretion: 
 (i) to select the Employees, Directors and
Consultants to whom Awards may be granted from time to time hereunder; 
 (ii) to determine whether and to what extent Awards
are granted hereunder; 
 (iii) to determine the number of Shares or the amount of other consideration to be covered by each
Award granted hereunder; 
 (iv) to approve forms of Award Agreements for use under the Plan; 

(v) to determine the terms and conditions of any Award granted hereunder; 

(vi) to amend the terms of any outstanding Award granted under the Plan, provided that (A) any amendment that would adversely
affect the Grantee’s rights under an outstanding Award shall not be made without the Grantee’s written consent, provided, however, that an amendment or modification that may cause an Incentive Stock Option to become a Non-Qualified Stock
Option shall not be treated as adversely affecting the rights of the Grantee, (B) the reduction of the exercise price of any Option awarded under the Plan and the base appreciation amount of any SAR awarded under the Plan shall be subject to
stockholder approval and (C) canceling an Option or SAR at a time when its exercise price or base appreciation amount (as applicable) exceeds the Fair Market Value of the underlying Shares, in exchange for another Option, SAR, Restricted Stock,
cash or other Award shall be subject to stockholder approval, unless the cancellation and exchange occurs in connection with a Corporate Transaction. Notwithstanding the foregoing, canceling an Option or SAR in exchange for another Option, SAR,
Restricted Stock, or other Award with an exercise price, purchase price or base appreciation amount (as applicable) that is equal to or greater than the exercise price or base appreciation amount (as applicable) of the original Option or SAR shall
not be subject to stockholder approval; 
 (vii) to construe and interpret the terms of the Plan and Awards, including without
limitation, any notice of award or Award Agreement, granted pursuant to the Plan; 

  
 8 

 (viii) to grant Awards to Employees, Directors and Consultants employed outside the United
States on such terms and conditions different from those specified in the Plan as may, in the judgment of the Administrator, be necessary or desirable to further the purpose of the Plan; and 

(ix) to take such other action, not inconsistent with the terms of the Plan, as the Administrator deems appropriate. 

In addition to the foregoing, the Administrator shall have the discretion to interpret or construe ambiguous, unclear, or implied (but omitted) terms in
any fashion it deems to be appropriate in its sole discretion, and to make any findings of fact needed in the administration of the Plan or Award Agreements. The Administrator’s prior exercise of its discretionary authority shall not obligate
it to exercise its authority in a like fashion thereafter. The Administrator’s interpretation and construction of any provision of the Plan, or of any Award or Award Agreement, and all determination the Administrator makes pursuant to the Plan
shall be final, binding, and conclusive. The validity of any such interpretation, construction, decision or finding of fact shall not be given de novo review if challenged in court, by arbitration, or in any other forum, and shall be upheld unless
clearly made in bad faith or materially affected by fraud. 
 The express grant in the Plan of any specific power to the Administrator shall not
be construed as limiting any power or authority of the Administrator; provided that the Administrator may not exercise any right or power reserved to the Board. Any decision made, or action taken, by the Administrator or in connection with the
administration of this Plan shall be final, conclusive and binding on all persons having an interest in the Plan. 
 (c)
Indemnification. In addition to such other rights of indemnification as they may have as members of the Board or as Officers or Employees of the Company or a Related Entity, members of the Board and any Officers or Employees of the Company or
a Related Entity to whom authority to act for the Board, the Administrator or the Company is delegated shall be defended and indemnified by the Company to the extent permitted by law on an after-tax basis against all reasonable expenses, including
attorneys’ fees, actually and necessarily incurred in connection with the defense of any claim, investigation, action, suit or proceeding, or in connection with any appeal therein, other than such matters relating to their participation in the
Plan, to which they or any of them may be a party by reason of any action taken or failure to act under or in connection with the Plan, or any Award granted hereunder, and against all amounts paid by them in settlement thereof (provided such
settlement is approved by the Company) or paid by them in satisfaction of a judgment in any such claim, investigation, action, suit or proceeding, except in relation to matters as to which it shall be adjudged in such claim, investigation, action,
suit or proceeding that such person is liable for gross negligence, bad faith or intentional misconduct; provided, however, that within thirty (30) days after the institution of such claim, investigation, action, suit or proceeding, such person
shall offer to the Company, in writing, the opportunity at the Company’s expense to defend the same. 
 5.
Eligibility. Awards other than Incentive Stock Options may be granted to Employees, Directors and Consultants. Incentive Stock Options may be granted only to Employees of the Company or a Parent or a Subsidiary of the Company. An Employee,
Director or Consultant who has been granted an Award may, if otherwise eligible, be granted additional Awards. Awards may be granted to such Employees, Directors or Consultants who are residing in non-U.S. jurisdictions as the Administrator may
determine from time to time. 

  
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 6. Terms and Conditions of Awards. 

(a) Types of Awards. The Administrator is authorized under the Plan to award any type of arrangement to an Employee, Director or
Consultant that is not inconsistent with the provisions of the Plan and that by its terms involves or might involve the issuance of (i) Shares, (ii) cash or (iii) an Option, a SAR, or similar right with a fixed or variable price
related to the Fair Market Value of the Shares and with an exercise or conversion privilege related to the passage of time, the occurrence of one or more events, or the satisfaction of performance criteria or other conditions. Such awards include,
without limitation, Options, SARs, sales or bonuses of Restricted Stock or Restricted Stock Units, and an Award may consist of one such security or benefit, or two (2) or more of them in any combination or alternative. 

(b) Designation of Award. Each Award shall be designated in the Award Agreement. In the case of an Option, the Option shall be
designated as either an Incentive Stock Option or a Non-Qualified Stock Option. However, notwithstanding such designation, an Option will qualify as an Incentive Stock Option under the Code only to the extent the $100,000 dollar limitation of
Section 422(d) of the Code is not exceeded. The $100,000 limitation of Section 422(d) of the Code is calculated based on the aggregate Fair Market Value of the Shares subject to Options designated as Incentive Stock Options which become
exercisable for the first time by a Grantee during any calendar year (under all plans of the Company or any Parent or Subsidiary of the Company). For purposes of this calculation, Incentive Stock Options shall be taken into account in the order in
which they were granted, and the Fair Market Value of the Shares shall be determined as of the grant date of the relevant Option. 
 (c) Conditions of Award. Subject to the terms of the Plan, the Administrator shall determine the provisions, terms, and conditions of each Award including, but not limited to, the Award vesting
schedule, repurchase provisions, rights of first refusal, forfeiture provisions, form of payment (cash, Shares, or other consideration) upon settlement of the Award, payment contingencies, and satisfaction of any performance criteria. The
performance criteria established by the Administrator may be based on any one of, or combination of, the following: (i) appreciation in and/or maintenance of the price of the Shares or any other publicly-traded securities of the Company,
(ii) earnings or loss per share, (iii) total stockholder return, (iv) operating margin, (v) gross margin, (vi) return on equity, (vii) return on assets or net assets, (viii) return on investment,
(ix) operating income, (x) net operating income, (xi) pre-tax profit, (xii) cash flow or cash flow per share (before or after dividends), (xiii) revenue, (xiv) improvement in or attainment of expense levels or working
capital levels, including cash, inventory and accounts receivable, (xv) earnings or losses (including earnings or losses before taxes, before interest and taxes, or before interest, taxes, depreciation and amortization), (xvi) economic
value added, (xvii) market share, (xviii) relative or absolute share price, (xix) pro forma net income, (xx) customer orders, (xxi) net sales, (xxii) revenue growth or product revenue growth, (xxiii) operating
income (before or after taxes), (xxiv) pre- or after-tax income or loss (before or after allocation of corporate overhead and bonus), (xxv) net income or loss (before or after taxes), (xxvi) return on equity, (xxvii) attainment
of strategic and operational initiatives, (xxviii) comparisons with various stock market indices, (xxix) implementation, completion or attainment 

  
 10 

 
of measurable objectives with respect to research, development, commercialization, products or projects, acquisitions and divestitures, (xxx) factoring transactions and recruiting and
maintaining personnel, (xxxi) gross profits, (xxxii) economic value-added models or equivalent metrics, (xxxiii) reductions in costs, (xxxiv) sales or licenses of the Company’s assets, including its intellectual property,
whether in a particular jurisdiction or territory or globally; or through partnering transactions), (xxxv) return on capital (including return on total capital or return on invested capital), (xxxvi) cash flow return on investment,
(xxxvii) year-end cash, (xxxviii) cash margin, (xxxix) debt reduction, (xl) stockholders equity, (xli) operating efficiencies, (xlii) research and development achievements, (xliii) strategic partnerships or
transactions (including in-licensing and out-licensing of intellectual property), (xliv) co-development, co-marketing, profit sharing, joint venture or other similar arrangements, (xlv) financial ratios, including those measuring
liquidity, activity, profitability or leverage, (xlvi) cost of capital or assets under management, (xlvii) financing and other capital raising transactions (including sales of the Company’s equity or debt securities,
(xlviii) factoring transactions, and (xlix) establishing relationships with commercial entities with respect to the marketing, distribution and sale of the Company’s products (including with group purchasing organizations,
distributors and other vendors). Such performance criteria also may be based solely by reference to the Company’s performance or the performance of a Subsidiary, division, business segment or business unit of the Company, or based upon the
relative performance of other companies or upon comparisons of any of the indicators of performance relative to other companies. The Administrator may also exclude charges related to an event or occurrence which the Administrator determines should
appropriately be excluded, including (A) restructurings, discontinued operations, extraordinary items, and other unusual or non-recurring charges, (B) an event either not directly related to the operations of the Company or not within the
reasonable control of the Company’s management, or (C) the cumulative effects of tax or accounting changes in accordance with U.S. generally accepted accounting principles. Such performance goals shall be set by the Administrator within
the time period prescribed by, and shall otherwise comply with the requirements of, Section 162(m) of the Code, and the regulations thereunder. Performance based Awards shall be subject to a performance period set by the Administrator and
partial achievement of the specified criteria may result in a payment or vesting corresponding to the degree of achievement as specified in the Award Agreement. 
 (d) Acquisitions and Other Transactions. The Administrator may issue Awards under the Plan in settlement, assumption or substitution for, outstanding awards or obligations to grant future awards in
connection with the Company or a Related Entity acquiring another entity, an interest in another entity or an additional interest in a Related Entity whether by merger, stock purchase, asset purchase or other form of transaction. 

(e) Deferral of Award Payment. The Administrator may establish one or more programs under the Plan to permit selected Grantees the
opportunity to elect to defer receipt of consideration upon exercise of an Award, satisfaction of performance criteria, or other event that absent the election would entitle the Grantee to payment or receipt of Shares or other consideration under an
Award. The Administrator may establish the election procedures, the timing of such elections, the mechanisms for payments of, and accrual of interest or other earnings, if any, on amounts, Shares or other consideration so deferred, and such other
terms, conditions, rules and procedures that the Administrator deems advisable for the administration of any such deferral program. 

  
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 (f) Separate Programs. The Administrator may establish one or more separate programs
under the Plan for the purpose of issuing particular forms of Awards to one or more classes of Grantees on such terms and conditions as determined by the Administrator from time to time. 

(g) Individual Limitations on Awards. 
 (i) Individual Limit for Options and SARs. The maximum number of Shares with respect to which Options and SARs may be granted to any Grantee in any calendar year shall be 1,500,000 Shares. The
foregoing limitation shall be adjusted proportionately in connection with any change in the Company’s capitalization pursuant to Section 11 below. To the extent required by Section 162(m) of the Code or the regulations thereunder, in
applying the foregoing limitations with respect to a Grantee, if any Option or SAR is canceled, the canceled Option or SAR shall continue to count against the maximum number of Shares with respect to which Options and SARs may be granted to the
Grantee. For this purpose, the repricing of an Option to the extent approved by stockholders (or in the case of a SAR, the base amount on which the stock appreciation is calculated is reduced to reflect a reduction in the Fair Market Value of the
Common Stock) shall be treated as the cancellation of the existing Option or SAR and the grant of a new Option or SAR. 
 (ii)
Individual Limit for Restricted Stock and Restricted Stock Units. For awards of Restricted Stock and Restricted Stock Units that are intended to be Performance-Based Compensation, the maximum number of Shares with respect to which such Awards
may be granted to any Grantee in any calendar year shall be 750,000 Shares. The foregoing limitation shall be adjusted proportionately in connection with any change in the Company’s capitalization pursuant to Section 11 below. 

(iii) Individual Limit for Cash Awards. For awards of cash, the maximum amount with respect to which such Awards may be granted
to any Grantee in any calendar year shall be $2,000,000. 
 (iv) Deferral. If the vesting or receipt of Shares under an
Award is deferred to a later date, any amount (whether denominated in Shares or cash) paid in addition to the original number of Shares subject to such Award will not be treated as an increase in the number of Shares subject to the Award if the
additional amount is based either on a reasonable rate of interest or on one or more predetermined actual investments such that the amount payable by the Company at the later date will be based on the actual rate of return of a specific investment
(including any decrease as well as any increase in the value of an investment). 
 (h) Early Exercise. The Award
Agreement may, but need not, include a provision whereby the Grantee may elect at any time while an Employee, Director or Consultant to exercise any part or all of the Award prior to full vesting of the Award. Any unvested Shares received pursuant
to such exercise may be subject to a repurchase right in favor of the Company or a Related Entity or to any other restriction the Administrator determines to be appropriate. 
 (i) Term of Award. The term of each Award shall be no more than ten (10) years from the date of grant thereof. However, in the case of an Incentive Stock Option granted

  
 12 

 
to a Grantee who, at the time the Option is granted, owns stock representing more than ten percent (10%) of the voting power of all classes of stock of the Company or any Parent or
Subsidiary of the Company, the term of the Incentive Stock Option shall be five (5) years from the date of grant thereof or such shorter term as may be provided in the Award Agreement. Notwithstanding the foregoing, the specified term of any
Award shall not include any period for which the Grantee has elected to defer the receipt of the Shares or cash issuable pursuant to the Award. 
 (j) Transferability of Awards. Awards may not be sold, pledged, assigned, hypothecated, transferred, or disposed of in any manner other than by will or by the laws of descent or distribution and
may be exercised during the lifetime of the Grantee only by the Grantee. Notwithstanding the foregoing, the Grantee may designate one or more beneficiaries of the Grantee’s Award in the event of the Grantee’s death on a beneficiary
designation form provided by the Administrator. 
 (k) Time of Granting Awards. The date of grant of an Award shall for
all purposes be the date on which the Administrator makes the determination to grant such Award, or such other date as is determined by the Administrator. 
 (l) Dividend Equivalents. Subject to the provisions of the Plan and any Award Agreement, the recipient of an Award other than an Option or SAR may, if so determined by the Committee, be entitled to
receive, currently or on a deferred basis, amounts equivalent to cash, stock or other property dividends on Shares (“Dividend Equivalents”) with respect to the number of Shares covered by the Award, as determined by the Committee,
in its sole discretion. The Committee may provide that the Dividend Equivalents (if any) shall be deemed to have been reinvested in additional Shares or otherwise reinvested and may provide that the Dividend Equivalents are subject to the same
vesting or performance conditions as the underlying Award. Notwithstanding the foregoing, Dividend Equivalents distributed in connection with an Award that vests based on the achievement of performance goals shall be subject to restrictions and risk
of forfeiture to the same extent as the Award with respect to which such cash, stock or other property has been distributed. 

7. Award Exercise or Purchase Price, Consideration and Taxes. 

(a) Exercise or Purchase Price. The exercise or purchase price, if any, for an Award shall be as follows: 

(i) In the case of an Incentive Stock Option: 
 (A) granted to an Employee who, at the time of the grant of such Incentive Stock Option owns stock representing more than ten percent (10%) of the voting power of all classes of stock of the Company
or any Parent or Subsidiary of the Company, the per Share exercise price shall be not less than one hundred ten percent (110%) of the Fair Market Value per Share on the date of grant; or 

(B) granted to any Employee other than an Employee described in the preceding paragraph, the per Share exercise price shall be not less
than one hundred percent (100%) of the Fair Market Value per Share on the date of grant. 

  
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 (ii) In the case of a Non-Qualified Stock Option, the per Share exercise price shall be not
less than one hundred percent (100%) of the Fair Market Value per Share on the date of grant. 
 (iii) In the case of
Awards intended to qualify as Performance-Based Compensation, the exercise or purchase price, if any, shall be not less than one hundred percent (100%) of the Fair Market Value per Share on the date of grant. 

(iv) In the case of SARs, the base appreciation amount shall not be less than one hundred percent (100%) of the Fair Market Value
per Share on the date of grant. 
 (v) In the case of other Awards, such price as is determined by the Administrator.

 (vi) Notwithstanding the foregoing provisions of this Section 7(a), in the case of an Award issued pursuant to
Section 6(d), above, the exercise or purchase price for the Award shall be determined in accordance with the provisions of the relevant instrument evidencing the agreement to issue such Award. 

(b) Consideration. Subject to Applicable Laws, the consideration to be paid for the Shares to be issued upon exercise or purchase
of an Award including the method of payment, shall be determined by the Administrator. In addition to any other types of consideration the Administrator may determine, the Administrator is authorized to accept as consideration for Shares issued
under the Plan the following, provided that the portion of the consideration equal to the par value of the Shares must be paid in cash or other legal consideration permitted by the Delaware General Corporation Law: 

(i) cash; 

(ii) check; 

(iii) surrender of Shares or delivery of a properly executed form of attestation of ownership of Shares as the Administrator may require
which have a Fair Market Value on the date of surrender or attestation equal to the aggregate exercise price of the Shares as to which said Award shall be exercised; 
 (iv) with respect to Options, payment through a broker-dealer sale and remittance procedure pursuant to which the Grantee (A) shall provide written instructions to a Company designated brokerage firm
to effect the immediate sale of some or all of the purchased Shares and remit to the Company sufficient funds to cover the aggregate exercise price payable for the purchased Shares and (B) shall provide written directives to the Company to
deliver the certificates for the purchased Shares directly to such brokerage firm in order to complete the sale transaction; 

(v) with respect to Options, payment through a “net exercise” such that, without the payment of any funds, the Grantee may
exercise the Option and receive the net number of Shares equal to (i) the number of Shares as to which the Option is being exercised, multiplied by (ii) a fraction, the numerator of which is the Fair Market Value per Share (on such

  
 14 

 
date as is determined by the Administrator) less the Exercise Price per Share, and the denominator of which is such Fair Market Value per Share (the number of net Shares to be received shall be
rounded down to the nearest whole number of Shares); or 
 (vi) any combination of the foregoing methods of payment.

 The Administrator may at any time or from time to time, by adoption of or by amendment to the standard forms of Award Agreement described in
Section 4(b)(iv), or by other means, grant Awards which do not permit all of the foregoing forms of consideration to be used in payment for the Shares or which otherwise restrict one or more forms of consideration. Except as required by
Applicable Law, the Administrator is not required to accept any of the above forms of consideration, as long as the Administrator provides for a reasonable payment alternative. 

(c) Taxes. No Shares shall be delivered under the Plan to any Grantee or other person until such Grantee or other person has made
arrangements acceptable to the Administrator for the satisfaction of any non-U.S., federal, state, or local income and employment tax withholding obligations, including, without limitation, obligations incident to the receipt of Shares. Upon
exercise or vesting of an Award the Company shall withhold or collect from the Grantee an amount sufficient to satisfy such tax obligations, including, but not limited to, by surrender of the whole number of Shares covered by the Award sufficient to
satisfy the minimum applicable tax withholding obligations incident to the exercise or vesting of an Award. 
 8. Vesting of
Awards. 
 (a) General. The time when an Award shall vest and become exercisable shall be stated in the Award Agreement.
The restrictions, if any, on Restricted Stock shall expire at the times designated in the Award Agreement. Notwithstanding the foregoing, (i) no Option shall vest before the one-year anniversary of the date of grant of such Option, unless such
vesting is accelerated in accordance with the other provisions of this Section 8 (not including this Section 8(a)) or Section 12, and (ii) no Restricted Stock or Restricted Stock Units shall vest faster than pro rata over a
three-year period from the date on which the Award was granted, unless such Restricted Stock was issued to replace a deferred Stock Award, to replace awards that a new Employee has forfeited from his or her previous employer or the restrictions
lapse earlier due to the other provisions of this Section 8 (not including this Section 8(a)) or Section 12. Notwithstanding the foregoing, the restrictions in the preceding sentence shall not be applicable to grants of up to 10% of
the number of Shares available for issuance pursuant to Awards as set forth in Section 3(a) on the effective date of the Plan. 
 (b) Death. The Administrator shall have the authority to promulgate rules and regulations to determine the treatment of a Grantee under the Plan in the event of such Grantee’s death. Unless
otherwise provided in an Award Agreement, in the event that a Grantee shall die while he or she is an Employee, Director or Consultant and prior to the complete exercise of Options or complete maturity of SARs granted to him or her under the Plan,
any such remaining Options or SARs shall be fully vested and may be exercised in whole or in part within one year after the date of the Grantee’s death and then only: (i) by the beneficiary designated by the Grantee in a writing submitted
to the Company prior to the Grantee’s death, or in the absence of 

  
 15 

 
same, by the Grantee’s estate or by or on behalf of such person or persons to whom the Grantee’s rights pass under his or her will or the laws of descent and distribution, (ii) to
the extent that the Grantee would have been entitled to exercise the Option or SAR at the date of his or her death had it been fully vested, and subject to all of the conditions on exercise imposed by the Plan and the Award Agreement, and
(iii) prior to the expiration of the term of the Option or SAR. Notwithstanding this Section 8(b) or the terms of an Award Agreement, the Administrator shall have the right to extend the period for exercise of an Option or SAR, up to one
year even if such extension exceeds the original term of such Option or SAR. 
 (c) Disability. The Administrator shall
have the authority to promulgate rules and regulations to determine the treatment of a Grantee under the Plan in the event of such Grantee’s Disability. Unless otherwise provided in an Award Agreement, in the event that a Grantee’s status
as an Employee, Director or Consultant terminates due to the Grantee’s Disability prior to the complete exercise of Options or complete maturity of SARs granted to him or her under the Plan, any such remaining Options or SARs shall be fully
vested and may be exercised in whole or in part up to three years after the Grantee’s termination of status due to Disability as an Employee, Director or Consultant, as the case may be. Notwithstanding this Section 8(c) or the terms of an
Award Agreement, the Administrator shall have the right to extend the period for exercise of an Option or SAR up to one year, even if such extension exceeds the term of such Option or SAR. 

(d) Termination for Cause. A Grantee who is terminated for Cause shall, unless otherwise determined by the Administrator,
immediately forfeit, effective as of the date the Grantee engages in such conduct, all unexercised, unearned, and/or unpaid Awards, including, but not by way of limitation, Awards earned but not yet paid, all unpaid dividends and dividend
equivalents, and all interest, if any, accrued on the foregoing. 
 9. Exercise of Award. 

(a) Procedure for Exercise; Rights as a Stockholder. 
 (i) Subject to Section 8, any Award granted hereunder shall be exercisable at such times and under such conditions as determined by the Administrator under the terms of the Plan and specified in the
Award Agreement. 
 (ii) An Award shall be deemed to be exercised when written notice of such exercise has been given to the
Company in accordance with the terms of the Award by the person entitled to exercise the Award and full payment for the Shares with respect to which the Award is exercised has been made, including, to the extent selected, use of the broker-dealer
sale and remittance procedure to pay the purchase price as provided in Section 7(b)(iv). 
 (b) Exercise of Award
Following Termination of Continuous Service. 
 (i) An Award may not be exercised after the termination date of such Award
set forth in the Award Agreement and, subject to Section 8, may be exercised following the termination of a Grantee’s Continuous Service only to the extent provided in the Award Agreement. 

  
 16 

 (ii) Where the Award Agreement permits a Grantee to exercise an Award following the
termination of the Grantee’s Continuous Service for a specified period, the Award shall terminate to the extent not exercised on the last day of the specified period or the last day of the original term of the Award, whichever occurs first.

 (iii) Any Award designated as an Incentive Stock Option to the extent not exercised within the time permitted by law for the
exercise of Incentive Stock Options following the termination of a Grantee’s Continuous Service shall convert automatically to a Non-Qualified Stock Option and thereafter shall be exercisable as such to the extent exercisable by its terms for
the period specified herein or in the Award Agreement. 
 10. Conditions Upon Issuance of Shares. 

(a) If at any time the Administrator determines that the delivery of Shares pursuant to the exercise, vesting or any other provision of
an Award is or may be unlawful under Applicable Laws, the vesting or right to exercise an Award or to otherwise receive Shares pursuant to the terms of an Award shall be suspended until the Administrator determines that such delivery is lawful and
shall be further subject to the approval of counsel for the Company with respect to such compliance. The Company shall have no obligation to effect any registration or qualification of the Shares under federal or state laws. 

(b) As a condition to the exercise of an Award, the Company may require the person exercising such Award to represent and warrant at the
time of any such exercise that the Shares are being purchased only for investment and without any present intention to sell or distribute such Shares, or to make such other representations and warranties if, in the opinion of counsel for the
Company, any such representations or warranties are required by any Applicable Laws. 
 11. Adjustments Upon Changes in
Capitalization. Subject to any required action by the stockholders of the Company, the number of Shares covered by each outstanding Award, and the number of Shares which have been authorized for issuance under the Plan but as to which no Awards
have yet been granted or which have been returned to the Plan, the exercise or purchase price of each such outstanding Award, the maximum number of Shares with respect to which Awards may be granted to any Grantee in any calendar year, as well as
any other terms that the Administrator determines require adjustment shall be proportionately adjusted for (i) any increase or decrease in the number of issued Shares resulting from a stock split, reverse stock split, stock dividend,
combination or reclassification of the Shares, or similar transaction affecting the Shares, (ii) any other increase or decrease in the number of issued Shares effected without receipt of consideration by the Company, or (iii) any other
transaction with respect to Common Stock including a corporate merger, consolidation, acquisition of property or stock, separation (including a spin-off or other distribution of stock or property), reorganization, liquidation (whether partial or
complete) or any similar transaction; provided, however, that conversion of any convertible securities of the Company shall not be deemed to have been “effected without receipt of consideration.” Any such adjustments to outstanding Awards
will be effected in a manner that precludes the material enlargement of rights and benefits under such Awards. Adjustments and any determinations or interpretations shall be made by the Administrator and its determination shall be final, binding and
conclusive. In connection with 

  
 17 

 
the foregoing adjustments, the Administrator may, in its discretion, prohibit the exercise of Awards or other issuance of Shares, cash or other consideration pursuant to Awards during certain
periods of time. Except as the Administrator determines, no issuance by the Company of shares of any class, or securities convertible into shares of any class, shall affect, and no adjustment by reason hereof shall be made with respect to, the
number or price of Shares subject to an Award. 
 12. Corporate Transactions and Changes in Control. 

(a) Termination of Award to Extent Not Assumed in Corporate Transaction. Effective upon the consummation of a Corporate
Transaction, all outstanding Awards under the Plan shall terminate. However, all such Awards shall not terminate to the extent they are Assumed in connection with the Corporate Transaction. Notwithstanding the foregoing, instead of having
outstanding Awards be Assumed, the Administrator may in its sole and absolute discretion and authority, without obtaining the approval or consent of the Company’s stockholders or any Grantee with respect to his or her outstanding Awards, take
one or more of the following actions (with respect to any or all of the Awards, and with discretion to differentiate between individual Grantees and Awards for any reason): 
 (i) arrange or otherwise provide for the payment of cash or other consideration to Grantees in exchange for the satisfaction and cancellation of all or some outstanding Awards (based on the Fair Market
Value, on the date of the Corporate Transaction, of the Award being cancelled, based on any reasonable valuation method selected by the Administrator, and with the Administrator having full discretion to cancel either all Awards or only select
Awards (such as only those that have vested on or before the Corporate Transaction); or 
 (ii) make such other modifications,
adjustments or amendments to outstanding Awards or this Plan as the Administrator deems necessary or appropriate, subject however to the terms set forth above. 
 (b) Acceleration of Award Upon Corporate Transaction or Change in Control. Except as provided otherwise in an individual Award Agreement, in the event of a Corporate Transaction or Change in
Control, for the portion of each Award that is neither Assumed nor Replaced, such portion of the Award shall automatically become fully vested and exercisable and be released from any repurchase or forfeiture rights (other than repurchase rights
exercisable at Fair Market Value) for all of the Shares (or other consideration) at the time represented by such portion of the Award, immediately prior to the specified effective date of such Corporate Transaction or Change in Control. 

(c) Effect of Acceleration on Incentive Stock Options. Any Incentive Stock Option accelerated under this Section 12 in
connection with a Corporate Transaction or Change in Control shall remain exercisable as an Incentive Stock Option under the Code only to the extent the $100,000 dollar limitation of Section 422(d) of the Code is not exceeded. 

13. Effective Date and Term of Plan. The Plan shall become effective upon its approval by the stockholders of the Company. It
shall continue in effect for a term of ten (10) years unless sooner terminated pursuant to Section 14. Subject to Section 18 below and Applicable Laws, Awards may be granted under the Plan upon its becoming effective. 

  
 18 

 14. Amendment, Suspension or Termination of the Plan. 

(a) The Board may at any time amend, suspend or terminate the Plan; provided, however, that no such amendment shall be made without the
approval of the Company’s stockholders to the extent such approval is required by Applicable Laws, or if such amendment would lessen the stockholder approval requirements of Section 4(b)(vi) or this Section 14(a). 

(b) No Award may be granted during any suspension of the Plan or after termination of the Plan. 

(c) No suspension or termination of the Plan (including termination of the Plan under Section 12, above) shall adversely affect any
rights under Awards already granted to a Grantee. 
 15. Reservation of Shares. 

(a) The Company, during the term of the Plan, will at all times reserve and keep available such number of Shares as shall be sufficient
to satisfy the requirements of the Plan. 
 (b) The inability of the Company to obtain authority from any regulatory body having
jurisdiction, which authority is deemed by the Company’s counsel to be necessary to the lawful issuance and sale of any Shares hereunder, shall relieve the Company of any liability in respect of the failure to issue or sell such Shares as to
which such requisite authority shall not have been obtained. 
 16. No Effect on Terms of Employment/Consulting
Relationship. The Plan shall not confer upon any Grantee any right with respect to the Grantee’s Continuous Service, nor shall it interfere in any way with his or her right or the right of the Company or any Related Entity to terminate the
Grantee’s Continuous Service at any time, with or without Cause, and with or without notice. The ability of the Company or any Related Entity to terminate the employment of a Grantee who is employed at will is in no way affected by its
determination that the Grantee’s Continuous Service has been terminated for Cause for the purposes of this Plan. 
 17.
No Effect on Retirement and Other Benefit Plans. Except as specifically provided in a retirement or other benefit plan of the Company or a Related Entity, Awards shall not be deemed compensation for purposes of computing benefits or
contributions under any retirement plan of the Company or a Related Entity, and shall not affect any benefits under any other benefit plan of any kind or any benefit plan subsequently instituted under which the availability or amount of benefits is
related to level of compensation. The Plan is not a “Retirement Plan” or “Welfare Plan” under the Employee Retirement Income Security Act of 1974, as amended. 

18. Stockholder Approval. The grant of Incentive Stock Options under the Plan shall be subject to approval by the stockholders of
the Company within twelve (12) months before or 

  
 19 

 
after the date the Plan is adopted, excluding Incentive Stock Options issued in substitution for outstanding Incentive Stock Options pursuant to Section 424(a) of the Code. Such stockholder
approval shall be obtained in the degree and manner required under Applicable Laws. The Administrator may grant Incentive Stock Options under the Plan prior to approval by the stockholders, but until such approval is obtained, no such Incentive
Stock Option shall be exercisable. In the event that stockholder approval is not obtained within the twelve (12) month period provided above, all Incentive Stock Options previously granted under the Plan shall be exercisable as Non-Qualified
Stock Options. 
 19. Unfunded Obligation. Grantees shall have the status of general unsecured creditors of the Company.
Any amounts payable to Grantees pursuant to the Plan shall be unfunded and unsecured obligations for all purposes, including, without limitation, Title I of the Employee Retirement Income Security Act of 1974, as amended. Neither the Company nor any
Related Entity shall be required to segregate any monies from its general funds, or to create any trusts, or establish any special accounts with respect to such obligations. The Company shall retain at all times beneficial ownership of any
investments, including trust investments, which the Company may make to fulfill its payment obligations hereunder. Any investments or the creation or maintenance of any trust or any Grantee account shall not create or constitute a trust or fiduciary
relationship between the Administrator, the Company or any Related Entity and a Grantee, or otherwise create any vested or beneficial interest in any Grantee or the Grantee’s creditors in any assets of the Company or a Related Entity. The
Grantees shall have no claim against the Company or any Related Entity for any changes in the value of any assets that may be invested or reinvested by the Company with respect to the Plan. 

20. Construction. Captions and titles contained herein are for convenience only and shall not affect the meaning or interpretation
of any provision of the Plan. Except when otherwise indicated by the context, the singular shall include the plural and the plural shall include the singular. Use of the term “or” is not intended to be exclusive, unless the context clearly
requires otherwise. 
 21. No Corporate Action Restriction. The existence of this Plan, the Award Agreements and the
Awards granted hereunder shall not limit, affect or restrict in any way the right or power of the Board or the stockholders of the Company to make or authorize: (i) any adjustment, recapitalization, reorganization or other change in the capital
structure or business of the Company or any Subsidiary, (ii) any merger, amalgamation, consolidation or change in the ownership of the Company or any Subsidiary, (iii) any issue of bonds, debentures, capital, preferred or prior preference
stock ahead of or affecting the capital stock (or the rights thereof) of the Company or any Subsidiary, (iv) any dissolution or liquidation of the Company or any Subsidiary, (v) any sale or transfer of all or any part of the assets or
business of the Company or any Subsidiary, or (vi) any other corporate act or proceeding by the Company or any Subsidiary. No Grantee, beneficiary or any other person shall have any claim under any Award or Award Agreement against any member of
the Board or the Administrator, or the Company or any Employees, Officers or agents of the Company or any Subsidiary, as a result of any such action. 
 22. Section 409A. To the extent that the Administrator determines that any Award granted under the Plan is subject to Section 409A, the Award Agreement evidencing such Award shall
incorporate the terms and conditions required by Section 409A. To the extent applicable, 

  
 20 

 
the Plan and Award Agreements shall be interpreted in accordance with Section 409A and Department of Treasury regulations and other interpretive guidance issued thereunder, including without
limitation, any such regulations or other guidance that may be issued after the adoption of this Plan. Notwithstanding any provision of the Plan to the contrary, the Administrator may adopt such amendments to the Plan and the applicable Award
Agreement or adopt other policies and procedures (including amendments, policies and procedures with retroactive effect), or take any other actions, that the Administrator determines are necessary or appropriate (i) to exempt the Award from
Section 409A and/or preserve the intended tax treatment of the benefits provided with respect to the Award, or (ii) to comply with the requirements of Section 409A and related Department of Treasury guidance and thereby avoid the
application of any penalty taxes under Section 409A including by retroactively cancelling such Award Agreements. 
 23.
Choice of Law. To the extent that U.S. federal law does not apply, and except as expressly set forth in an applicable Award Agreement, this Plan, the Awards, all documents evidencing Awards and all other related documents shall be governed
by, and construed in accordance with, the laws of the State of Delaware, without regard to conflict of laws rules. 
 24.
Severability. In the event that any one or more of the provisions of this Plan shall be or become invalid, illegal or unenforceable in any respect, the validity, legality and enforceability of the remaining provisions contained herein shall
not be affected thereby. If, in the opinion of any court of competent jurisdiction such provision or provisions are not enforceable in any respect, such court shall have the right, power and authority to excise or modify such provision or provisions
to make them enforceable and to enforce the remainder of these provisions as so amended. 
 25. Recoupment of Awards.
Unless otherwise specifically provided in an Award Agreement, and to the extent permitted by Applicable Law, the Administrator may in its sole and absolute discretion, without obtaining the approval or consent of the Company’s stockholders
or of any Grantee, require that any Grantee reimburse the Company for all or any portion of any Awards granted under this Plan (“Reimbursement”), or the Administrator may require the termination of any outstanding, unexpired,
unpaid, or deferred Awards (“Termination”), rescission of any delivery pursuant to the Award (“Rescission”), or the or Rescission of, or the recapture any Shares (whether restricted or unrestricted) or proceeds from
the Grantee’s sale of Shares issued pursuant to the Award (“Recapture”) of an Award, if and to the extent: 
 (a) the granting, vesting, or payment of such Award was predicated on the achievement of certain financial results that were subsequently the subject of a material financial restatement; 

(b) in the Administrator’s view the Grantee engaged in fraud or misconduct that caused or partially caused the need for a material
financial restatement by the Company or any Affiliate; and 
 (c) a lower granting, vesting, or payment of such Award otherwise
would have occurred. 

  
 21 

 In addition, the Administrator may require the Termination or Rescission of, or the Recapture associated
with, any Award, if and to the extent required by Applicable Law. In each instance, the Administrator will, to the extent practicable and allowable under Applicable Laws, require Reimbursement, Termination or Rescission of, or Recapture relating to,
any such Award granted to a Grantee, provided that the Company will not seek Reimbursement, Termination or Rescission of, or Recapture relating to, any such Awards that were paid or vested more than three years prior to the first date of the
applicable restatement period, unless required to do so by Applicable Law. 

  
 22 

 ACCELRYS, INC. 

2011 STOCK INCENTIVE PLAN 
 STOCK OPTION AGREEMENT 
 Pursuant to the Accelrys, Inc. (the
“Company”) 2011 Stock Incentive Plan (the “Plan”), the Company hereby grants to you, «Name» (the “Grantee”) an option to purchase that number of shares of the Company’s
Common Stock set forth below (the “Option”), subject to the terms and conditions below. Capitalized terms used and not otherwise defined herein shall have the meanings given to such terms in the Plan, a copy of which is available on
the Accelrys intranet website and attached hereto as Attachment 1. 
 1. GOVERNING PLAN
DOCUMENT. Your Option is subject to all of the provisions of the Plan, which provisions are hereby made a part of this Stock Option Agreement. In the event of any conflict between the provisions of this Stock Option
Agreement and the provisions of the Plan, the provisions of the Plan shall control in all respects. 
 2. DETAILS
OF OPTION. The details of your Option are as follows: 
  

			
	Date of Grant:	  	  

	Vesting Commencement Date:	  	  

	Number of Shares Subject to Option:	  	  

	Exercise Price (Per Share):	  	  

	Expiration Date:	  	  

		  	The earlier of (1) the 10th anniversary of the Date of Grant indicated above and (2) the 90th day following the date of termination of your employment with the Company for any
reason other than death, Disability or Cause.
		
	Type of Grant:	  	 ̈ Incentive Stock Option*
		
		  	 ̈ Non-Qualified Stock Option
		
	 Exercise

Schedule:
	  	 ̈ Same as Vesting Schedule      ̈ Early Exercise
Permitted
		
	Vesting Schedule:	  	

 3. EXERCISE. You may exercise your Option only for whole shares of Common Stock and
only as set forth in the Plan. In order to exercise your Option, you must submit to the Company payment via any means permitted by the Plan for that number of shares of Common Stock you 

 

	*	 If this is an Incentive Stock Option, it (plus any other outstanding Incentive Stock Options held by the Grantee) cannot be first
exercisable for more than $100,000 in value (measured by exercise price) in any calendar year. Any excess over $100,000 shall be deemed a Non-Qualified Stock Option. Please refer to the Plan for additional details.

 
are electing to purchase pursuant to your Option. In the event that your Option is an Incentive Stock Option, by exercising your Option you expressly agree that you will notify the Company in
writing within fifteen (15) days after the date of any disposition of any of the shares of the Common Stock issued upon exercise of your Option that occurs within two (2) years after the date of your Option grant or within one
(1) year after such shares of Common Stock are issued upon exercise of your Option. Notwithstanding the foregoing, you expressly acknowledge and agree that no shares will be delivered to you or any other person on your behalf until you or such
other person has made arrangements acceptable to the Administrator for the satisfaction of any non-U.S., federal, state, or local income and employment tax withholding obligations, including, without limitation, obligations incident to the receipt
of shares upon exercise of this Option. Accordingly, but without limiting the generality of the foregoing, you and the Company expressly acknowledge and agree that, as a condition to the exercise of your Option, the Company may require you to enter
into an arrangement providing for the payment by you to the Company of any tax withholding obligation of the Company or any of its Subsidiaries or Affiliates arising by reason of the exercise of your Option, the lapse of any substantial risk of
forfeiture to which the shares of Common Stock underlying your Option are subject at the time of exercise, or the disposition of shares of Common Stock acquired upon the exercise of your Option. 

4. “EARLY EXERCISE”. If it is indicated in Section 2 that “early
exercise” of your Option is permitted, then you may elect at any time that is both during the period of your full- or part-time employment or service with the Company or any of its Subsidiaries or Affiliates that employ you, as the case may be,
and during the term of your Option to exercise all or part of your Option, including the unvested portion of your Option; provided, however, that: (i) a partial exercise of your Option shall be deemed to cover first vested shares of Common
Stock and then the earliest vesting installment of unvested shares of Common Stock; (ii) any shares of Common Stock so purchased from installments that have not vested as of the date of exercise shall be subject to the repurchase option in
favor of the Company as described in the Company’s form of Early Exercise Stock Purchase Agreement, a copy of which will be provided to you at the time you elect to “early exercise” your Option; and (iii) you shall enter into the
Company’s form of Early Exercise Stock Purchase Agreement with a vesting schedule that will result in the same vesting as if no early exercise had occurred. 
 5. TERM. You may not exercise your Option before the commencement of its term or after its term expires. The term of your Option commences on the Date of Grant
indicated in Section 2 and expires upon the Expiration Date set forth in Section 2. 
 6. MARKET
STAND-OFF AGREEMENT. By exercising your Option, you agree that you shall not sell, dispose of, transfer, make any short sale of, grant any option for the purchase of, or enter into any
hedging or similar transaction with the same economic effect as a sale, any shares or other securities of the Company held by you, for a period of time specified by the managing underwriter(s) (not to exceed one hundred eighty (180) days or
such other period as may be requested by the Company or an underwriter to accommodate regulatory restrictions on (i) the publication or other distribution of research reports and (ii) analyst recommendations and opinions, including, but
not limited to, the restrictions contained in FINRA Rule 2711(f)(4) or NYSE Rule 472(f)(4), or any successor provisions or amendments thereto) following the effective date of a registration statement of the Company filed under the Securities Act
(the 

  
 2 

 
“Lock-Up Period”); provided, however, that nothing contained in this Section 6 shall prevent the exercise of a repurchase option, if any, in favor of
the Company during the Lock-Up Period. You further agree to execute and deliver such other agreements as may be reasonably requested by the Company and/or the underwriter(s) that are consistent with the foregoing or that are necessary to give
further effect thereto. In order to enforce the foregoing covenant, the Company may impose stop-transfer instructions with respect to your shares of Common Stock until the end of such period. The underwriters of the Company’s stock are intended
third-party beneficiaries of this Section 6 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. 
 7. NOT A CONTRACT OF EMPLOYMENT. By executing this Award, you acknowledge and agree that
(i) nothing in this Award or the Plan confers on you any right to be employed by or continue any employment, service or consulting relationship with the Company or any of its Subsidiaries or Affiliates; and (ii) the Company would not have
granted this Award to you but for this acknowledgement and agreement. Under no circumstances will the Plan or this Stock Option Agreement be considered to be part of the terms and conditions of your employment with the Company or any of its
Subsidiaries or Affiliates that employs you. 
 8. GOVERNING LAW; JURISDICTION
AND VENUE. This Stock Option Agreement shall be construed in accordance with, and governed in all respects by, the internal laws of the State of Delaware without giving effect to its principles of
conflicts of laws. Any legal action or other legal proceeding relating to this Stock Option Agreement or the enforcement of any provision of this Stock Option Agreement shall be brought or otherwise commenced exclusively in any state or federal
court located in the County of San Diego, State of California. Each of the parties hereto: (i) expressly and irrevocably consents and submits to the jurisdiction of each state and federal court located in the County of San Diego, State of
California, in connection with any legal proceeding; (ii) agrees that each state and federal court located in the County of San Diego, State of California, shall be deemed to be a convenient forum; and (iii) agrees not to assert, by way of
motion, as a defense or otherwise, in any such legal proceeding commenced in any state or federal court located in the County of San Diego, State of California, any claim that it is not subject personally to the jurisdiction of such court, that such
legal proceeding has been brought in an inconvenient forum, that the venue of such proceeding is improper or that this Stock Option Agreement or the subject matter of this Stock Option Agreement may not be enforced in or by such court. 

9. NOTICES. Any notices to be delivered pursuant to this Stock Option Agreement shall be given in writing and shall
be deemed effectively given upon receipt or, in the case of notices delivered by mail by the Company to you, five (5) days after deposit in the United States mail, postage prepaid, addressed to you at the last address you provided to the
Company. 
 10. SEVERABILITY. If one or more provisions of this Stock Option Agreement are held to be
unenforceable under applicable law, such provision shall be excluded from this Stock Option Agreement and the balance of the Stock Option Agreement shall be interpreted as if such provision were so excluded and shall be enforceable in accordance
with its terms. 
 11. BINDING AND ENTIRE AGREEMENT. The terms
and conditions of this Stock Option Agreement shall inure to the benefit of and be binding upon the respective successors and 

  
 3 

 
assigns of the parties. This Stock Option Agreement, together with the Plan and any attachments hereto or thereto, constitute the full and entire understanding and agreement between the parties
with regard to the subjects hereof and thereof no party shall be liable or bound to any other party in any manner by any representations, warranties, covenants and agreements except as specifically set forth herein and therein. 

12. COUNTERPARTS. This Stock Option Agreement may be executed in two or more counterparts, each of which shall be
deemed an original and all of which together shall constitute one instrument. 
  

									
	COMPANY:	 		 	GRANTEE:
				
	ACCELRYS, INC.	 		 		 	
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	Scipio M. Carnecchia	 		 	Name:	 	  

	Title:	 	President and Chief Executive	 		 		 	

 GRANT SUMMARY: 

On «Grant_Date», «Name» hereby receives a Non-Qualified Stock Option to purchase up to
«Shares_Granted» shares of Common Stock of the Company at an exercise price of $«Grant_Price» per share. 

  
 4 

 ACCELRYS, INC. 

2011 STOCK INCENTIVE PLAN 
 RESTRICTED STOCK UNIT AWARD AGREEMENT 
 Pursuant to the Accelrys, Inc. (the
“Company”) 2011 Stock Incentive Plan (the “Plan”), the Company hereby grants to you, «Name» (the “Grantee”) that number of restricted units of the Company’s Common Stock set
forth below (the “Restricted Stock Unit Award”) subject to the terms and conditions below. Capitalized terms used and not otherwise defined herein shall have the meanings given to such terms in the Plan, a copy of which is available
on the Accelrys intranet website and attached hereto as Attachment 1. 
 1. GOVERNING PLAN DOCUMENT. Your Restricted Stock Unit
Award is subject to all of the provisions of the Plan, which provisions are hereby made a part of this Restricted Stock Unit Award Agreement. In the event of any conflict between the provisions of this Restricted Stock Unit Award Agreement and the
provisions of the Plan, the provisions of the Plan shall control in all respects. 
 2. DETAILS OF RESTRICTED STOCK AWARD. The details of
your Restricted Stock Award Unit are as follows: 
  

			
	Number of Shares of Common Stock Subject to Award:	  	# Shares
		
	Award Date:	  	Award Date
		
	Vesting Schedule:	  	

 3. SATISFACTION OF VESTING RESTRICTIONS; ACCOUNT. No shares of Common Stock will be issued to you pursuant to your
Restricted Stock Unit Award until such shares vest in accordance with the Vesting Schedule indicated in Section 2. As soon as practicable after the date on which any shares of Common Stock subject to your Restricted Stock Unit Award vest, the
Company will issue to you, free from further vesting restrictions, uncertificated shares in book entry form or share certificates representing such vested whole shares of Common Stock. Prior to the time any shares of Common Stock subject to your
Restricted Stock Unit Award vest, whenever dividends, whether payable in cash, stock or other property, are declared on such shares, on the date any such dividend is paid, the Company will credit to a bookkeeping account (the
“Account”) maintained by the Company for your benefit appropriate Dividend Equivalents in respect of the number of unvested shares of Common Stock subject to your Restricted Stock Unit Award on the record date for such dividend. Any
such Dividend Equivalent will be released from the Account and paid or issued to you as your Restricted Stock Unit Award vests. In the event that any such Dividend Equivalent consists of shares of Common Stock, the Company shall issue such shares to
you free from any vesting restrictions, in uncertificated book entry form or in share certificates representing whole shares of Common Stock. 

 4. TERMINATION OF EMPLOYMENT OR SERVICE WITH THE COMPANY OR ANY OF ITS SUBSIDIARIES OR AFFILIATES.
If, at any time prior to the vesting in full of the shares of Common Stock subject to your Restricted Stock Unit Award, your full- or part-time employment or service with the Company or any of its Subsidiaries or Affiliates terminates for any
reason, the unvested portion of your Restricted Stock Unit Award shall be canceled and become automatically null and void. 
 5.
REPRESENTATIONS. In connection with the acquisition of shares of Common Stock pursuant to this Restricted Stock Unit Award Agreement, you represent and warrant to the Company that you have no present intention of distributing or selling the
Common Stock, except as permitted under applicable securities laws. You further acknowledge and agree that your ability to sell the Common Stock may be limited by the Securities Act (including, without limitation, Rule 144 promulgated under the
Securities Act) and by the terms and conditions of this Restricted Stock Award Unit Agreement and the Plan. 
 6. NOT A CONTRACT OF
EMPLOYMENT. By executing this Award, you acknowledge and agree that (i) nothing in this Award or the Plan confers on you any right to be employed by or continue any employment, service or consulting relationship with the Company or any of
its Subsidiaries or Affiliates; and (ii) the Company would not have granted this Award to you but for this acknowledgement and agreement. Under no circumstances will the Plan or this Restricted Stock Unit Award Agreement be considered to be
part of the terms and conditions of your employment with the Company or any of its Subsidiaries or Affiliates that employs you. 
 7.
GOVERNING LAW; JURISDICTION AND VENUE. This Restricted Stock Unit Award Agreement shall be construed in accordance with, and governed in all respects by, the internal laws of the State of Delaware without giving effect to its principles of
conflicts of laws. Any legal action or other legal proceeding relating to this Restricted Stock Unit Award Agreement or the enforcement of any provision of this Restricted Stock Unit Award Agreement shall be brought or otherwise commenced
exclusively in any state or federal court located in the County of San Diego, State of California. Each of the parties hereto: (i) expressly and irrevocably consents and submits to the jurisdiction of each state and federal court located in the
County of San Diego, State of California, in connection with any legal proceeding; (ii) agrees that each state and federal court located in the County of San Diego, State of California, shall be deemed to be a convenient forum; and
(iii) agrees not to assert, by way of motion, as a defense or otherwise, in any such legal proceeding commenced in any state or federal court located in the County of San Diego, State of California, any claim that it is not subject personally
to the jurisdiction of such court, that such legal proceeding has been brought in an inconvenient forum, that the venue of such proceeding is improper or that this Restricted Stock Unit Award Agreement or the subject matter of this Restricted Stock
Unit Award Agreement may not be enforced in or by such court. 
 8. NOTICES. Any notices to be delivered pursuant to this Restricted
Stock Unit Award Agreement shall be given in writing and shall be deemed effectively given upon receipt or, in the case of notices delivered by mail by the Company to you, five (5) days after deposit in the United States mail, postage prepaid,
addressed to you at the last address you provided to the Company. 

  
 2 

 9. SEVERABILITY. If one or more provisions of this Restricted Stock Unit Award Agreement are held to
be unenforceable under applicable law, such provision shall be excluded from this Restricted Stock Unit Award Agreement and the balance of the Restricted Stock Unit Award Agreement shall be interpreted as if such provision were so excluded and shall
be enforceable in accordance with its terms. 
 10. BINDING AND ENTIRE AGREEMENT. The terms and conditions of this Restricted Stock Unit
Award Agreement shall inure to the benefit of and be binding upon the respective successors and assigns of the parties. This Restricted Stock Unit Award Agreement, together with the Plan and any attachments hereto or thereto, constitute the full and
entire understanding and agreement between the parties with regard to the subjects hereof and thereof no party shall be liable or bound to any other party in any manner by any representations, warranties, covenants and agreements except as
specifically set forth herein and therein. 
 11. COUNTERPARTS. This Restricted Stock Unit Award Agreement may be executed in two or more
counterparts, each of which shall be deemed an original and all of which together shall constitute one instrument. 
  

									
	COMPANY:	 		 	GRANTEE:
				
	ACCELRYS, INC.	 		 		 	
					
	By:	 	  
	 		 	By:	 	  

	Name:	 	Scipio M. Carnecchia	 		 	Name:	 	  

	Title:	 	President and Chief Executive	 		 		 	

 GRANT SUMMARY: 
 On Award Date, Name hereby receives a Restricted Stock Unit Award for # Shares shares of Common Stock of the Company. 
 US 

  
 3 

 ACCELRYS, INC. 

2011 STOCK INCENTIVE PLAN 
 DIRECTOR RESTRICTED STOCK UNIT AWARD AGREEMENT 
 Pursuant to the Accelrys,
Inc. (the “Company”) 2011 Stock Incentive Plan (the “Plan”), the Company hereby grants to «Name», as a director of the Company (the “Grantee”), that number of restricted units of
Common Stock (the “Restricted Stock Unit Award”) subject to the terms and conditions below. Capitalized terms used and not otherwise defined herein shall have the meanings given to such terms in the Plan, a copy of which is attached
hereto as Attachment 1. 
 1. GOVERNING PLAN DOCUMENT. Your Restricted Stock Unit Award is subject to all of the provisions of the
Plan, which provisions are hereby made a part of this Restricted Stock Unit Award Agreement. In the event of any conflict between the provisions of this Restricted Stock Unit Award Agreement and the provisions of the Plan, the provisions of the Plan
shall control in all respects. 
 2. DETAILS OF RESTRICTED STOCK AWARD. The details of your Restricted Stock Award Unit are as follows:

  

			
	Number of Shares of Common Stock Subject to Award:	  	# Shares
		
	Award Date:	  	Award Date
		
	Vesting Commencement Date:	  	Award Date
		
	Vesting Schedule:	  	

 3. SATISFACTION OF VESTING RESTRICTIONS; ACCOUNT. No shares of Common Stock will be issuable to you pursuant to
your Restricted Stock Unit Award until such shares vest in accordance with the Vesting Schedule indicated in Section 2. As soon as practicable after the date on which any shares of Common Stock subject to your Restricted Stock Unit Award vest,
the Company will credit to a bookkeeping account (the “Account”) maintained by the Company for your benefit such vested shares of Common Stock (collectively, the “Deferred Awards”), which shall be maintained in the
Account until such time as such Deferred Awards are to be paid to you pursuant to Section 4. Prior to the time of such payment, whenever any dividends, whether payable in cash, stock or other property, are declared on the Deferred Awards, on
the date any such dividend is paid, the Company will credit to the Account such Dividend Equivalents in respect of the Deferred Awards in such Account on the record date for such dividend. Additionally, prior to the time any shares of Common Stock
subject to your Restricted Stock Unit Award vest, whenever any dividends, whether payable in cash, stock or other property, are declared on such shares, on the date any such dividend is paid, the Company will credit to the Account appropriate
Dividend Equivalents in respect of the number of unvested shares of Common Stock subject to your Restricted Stock Unit Award on the record date for 

 
such dividend. Any such Dividend Equivalents payable or issuable in respect of your Restricted Stock Unit Award will be maintained in the Account until such time as the Deferred Awards are paid
to you pursuant to Section 4. 
 4. PAYMENTS OF DEFERRED AWARDS. The Company shall make a payment to you of the Deferred Awards
credited to the Account as provided in Section 3 upon the earlier to occur of: (i) the cessation of your service as a director of the Company for any reason; and (ii) the three-year anniversary of the date of this Restricted Stock
Unit Award Agreement. Notwithstanding the foregoing, you may elect to change the payment event set forth in clause (ii) of the preceding sentence by written notice delivered to the Company at least 12 months prior to the such payment event,
provided that the new payment event must be at least five years after the previously applicable payment event. 
 5. TERMINATION OF SERVICE
WITH THE COMPANY. If, at any time prior to the vesting in full of the shares of Common Stock subject to your Restricted Stock Unit Award, your service with the Company terminates for any reason, the unvested portion of your Restricted Stock Unit
Award shall be canceled and become automatically null and void. 
 6. REPRESENTATIONS. In connection with the acquisition of shares of
Common Stock pursuant to this Restricted Stock Unit Award Agreement, you represent and warrant to the Company that you have no present intention of distributing or selling the Common Stock, except as permitted under applicable securities laws. You
further acknowledge and agree that your ability to sell the Common Stock may be limited by the Securities Act (including, without limitation, Rule 144 promulgated under the Securities Act) and by the terms and conditions of this Restricted Stock
Award Unit Agreement and the Plan. 
 7. NOT A CONTRACT OF EMPLOYMENT. By executing this Award, you acknowledge and agree that
(i) nothing in this Award or the Plan confers on you any right to be employed by or continue any employment, service or consulting relationship with the Company or any of its Subsidiaries or Affiliates; and (ii) the Company would not have
granted this Award to you but for this acknowledgement and agreement. 
 8. COMPLIANCE WITH SECTION 409A. This Restricted Stock Unit
Award Agreement is intended to comply and shall be administered in a manner that is intended to comply with Section 409A of the Code and shall be construed and interpreted in accordance with such intent. Payment under this Restricted Stock Unit
Award Agreement shall be made in a manner that will comply with Section 409A of the Code, including regulations or other guidance issued with respect thereto, except as otherwise determined by the Administrator. Any provision of this Restricted
Stock Unit Award Agreement that would cause the payment or settlement thereof to fail to satisfy Section 409A of the Code shall be amended to comply with Section 409A of the Code on a timely basis, which may be made on a retroactive basis,
in accordance with regulations and other guidance issued under Section 409A of the Code. 
 9. GOVERNING LAW; JURISDICTION AND
VENUE. This Restricted Stock Unit Award Agreement shall be construed in accordance with, and governed in all respects by, the internal laws of the State of Delaware without giving effect to its principles of conflicts of laws. Any legal action
or other legal proceeding relating to this Restricted Stock Unit Award Agreement or 

  
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the enforcement of any provision of this Restricted Stock Unit Award Agreement shall be brought or otherwise commenced exclusively in any state or federal court located in the County of San
Diego, State of California. Each of the parties hereto: (i) expressly and irrevocably consents and submits to the jurisdiction of each state and federal court located in the County of San Diego, State of California, in connection with any legal
proceeding; (ii) agrees that each state and federal court located in the County of San Diego, State of California, shall be deemed to be a convenient forum; and (iii) agrees not to assert, by way of motion, as a defense or otherwise, in
any such legal proceeding commenced in any state or federal court located in the County of San Diego, State of California, any claim that it is not subject personally to the jurisdiction of such court, that such legal proceeding has been brought in
an inconvenient forum, that the venue of such proceeding is improper or that this Restricted Stock Unit Award Agreement or the subject matter of this Restricted Stock Unit Award Agreement may not be enforced in or by such court. 

10. NOTICES. Any notices to be delivered pursuant to this Restricted Stock Unit Award Agreement shall be given in writing and shall be deemed
effectively given upon receipt or, in the case of notices delivered by mail by the Company to you, five (5) days after deposit in the United States mail, postage prepaid, addressed to you at the last address you provided to the Company.

 11. SEVERABILITY. If one or more provisions of this Restricted Stock Unit Award Agreement are held to be unenforceable under
applicable law, such provision shall be excluded from this Restricted Stock Unit Award Agreement and the balance of the Restricted Stock Unit Award Agreement shall be interpreted as if such provision were so excluded and shall be enforceable in
accordance with its terms. 
 12. BINDING AND ENTIRE AGREEMENT. The terms and conditions of this Restricted Stock Unit Award Agreement
shall inure to the benefit of and be binding upon the respective successors and assigns of the parties. This Restricted Stock Unit Award Agreement, together with the Plan and any attachments hereto or thereto, constitute the full and entire
understanding and agreement between the parties with regard to the subjects hereof and thereof no party shall be liable or bound to any other party in any manner by any representations, warranties, covenants and agreements except as specifically set
forth herein and therein. 

  
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 13. COUNTERPARTS. This Restricted Stock Unit Award Agreement may be executed in two or more
counterparts, each of which shall be deemed an original and all of which together shall constitute one instrument. 
  

			
	COMPANY:
	
	ACCELRYS, INC.
		
	By:	 	  

	Name:	 	Scipio M. Carnecchia
	Title:	 	President and Chief Executive Officer
	
	GRANTEE:
		
	By:	 	  

	Name:	 	  

 GRANT SUMMARY: 

On Award Date, Name hereby receives a Restricted Stock Unit Award for # Shares shares of Common Stock of the Company. 

  
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