Document:

EX-4.4

 Exhibit 4.4 

Execution Version 

THIRD SUPPLEMENTAL INDENTURE (this “Third Supplemental Indenture”), dated as of January 26, 2015, among Medtronic Global
Holdings, SCA (the “Guarantor”), a corporate partnership limited by shares (société en commandite par actions) organized under the laws of the Grand Duchy of Luxembourg and an affiliate of Medtronic, Inc. (the
“Company”), and Wells Fargo Bank, National Association, a national banking association duly organized under the laws of the United States, as trustee (the “Trustee”). 

W I T N E S S E T H 

WHEREAS, the Company has heretofore executed and delivered to the Trustee an indenture dated as of December 10, 2014 (the
“Base Indenture”), providing for the issuance from time to time of its debentures, notes or other evidences of indebtedness (herein called the “Securities”), to be issued in one or more series as provided in the
Base Indenture; 
 WHEREAS, the Company has heretofore executed and delivered to the Trustee a first supplemental indenture
dated as of December 10, 2014 (the “First Supplemental Indenture” and, together with the Base Indenture, the “Indenture”) providing for the issuance of $500,000,000 aggregate principal amount of floating rate
senior notes due 2020, $1,000,000,000 aggregate principal amount of 1.500% senior notes due 2018, $2,500,000,000 aggregate principal amount of 2.500% senior notes due 2020, $2,500,000,000 aggregate principal amount of 3.150% senior notes due 2022,
$4,000,000,000 aggregate principal amount of 3.500% senior notes due 2025, $2,500,000,000 aggregate principal amount of 4.375% senior notes due 2035 and $4,000,000,000 aggregate principal amount of 4.625% senior notes due 2045 (collectively, the
“Notes”); 
 WHEREAS, Section 9.01(l) of the Base Indenture provides that, under certain circumstances, and
without the consent of the Holders of any series of Securities, a Guarantor may execute and deliver to the Trustee a supplemental indenture pursuant to which the Guarantor shall unconditionally guarantee all of the Company’s obligations under
the Securities, including the Notes, and the Indenture, on the terms and conditions set forth herein and under the Indenture; and 

WHEREAS, pursuant to Section 9.01 of the Base Indenture, the Trustee is authorized to execute and deliver this Third Supplemental
Indenture. 
 NOW THEREFORE, in consideration of the foregoing and for other good and valuable consideration, the receipt of which is hereby
acknowledged, the parties mutually covenant and agree for the equal and ratable benefit of the Holders as follows: 
 1. Amendments to the
Base Indenture. The following definition in Section 1.01 of the Base Indenture is amended and restated to read as follows: 

“Board of Directors” means, with respect to the Company, either the board of directors of the Company, any
duly authorized committee of that board or any other equivalent governing entity of the Company and, with respect to any Guarantor, the board of directors of such Guarantor, any duly authorized committee of that board or any other equivalent
governing entity of such Guarantor. 

 2. Capitalized Terms. Capitalized terms used herein without definition shall have the
meanings assigned to them in the Indenture. 
 3. Guarantor. The Guarantor hereby agrees to be a Guarantor under the Indenture and to
be bound by the terms of the Indenture and the Securities, including the Notes, applicable to Guarantors, including, but not limited to, Article 14 of the Indenture, as amended and supplemented by this Third Supplemental Indenture, and further
agrees that this Third Supplemental Indenture is the legal, valid and binding obligation of the Guarantor, enforceable against it in accordance with its terms. 

4. Relationship to Existing Base Indenture. This Third Supplemental Indenture is a supplemental indenture within the meaning of the Base
Indenture. The Indenture, as amended and supplemented by this Third Supplemental Indenture, is in all respects ratified, confirmed and approved and, with respect to the Securities, including the Notes, the Indenture, as amended and supplemented by
this Third Supplemental Indenture, shall be read, taken and construed as one and the same instrument. 
 5. Governing Law. THIS THIRD
SUPPLEMENTAL INDENTURE WILL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK. 
 6. Waiver of Jury
Trial. EACH OF THE GUARANTOR AND THE TRUSTEE HEREBY IRREVOCABLY WAIVES, TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR RELATING TO THIS THIRD SUPPLEMENTAL
INDENTURE, THE NOTE GUARANTEE OR THE TRANSACTION CONTEMPLATED HEREBY. 
 7. Consent to Jurisdiction; Appointment of Agent for Service of
Process. 
 To the fullest extent permitted by applicable law, the Guarantor hereby irrevocably submits to the jurisdiction of any
Federal or State court located in the Borough of Manhattan in The City of New York, New York, in any suit, action or proceeding based on or arising out of or relating to this Third Supplemental Indenture and the Note Guarantee and irrevocably agrees
that all claims in respect of such suit or proceeding may be determined in any such court. The guarantor irrevocably waives, to the fullest extent permitted by law, any objection which it may have to the laying of the venue of any such suit, action
or proceeding brought in an inconvenient forum. The Guarantor agrees that final judgment in any such suit, action or proceeding brought in such a court shall be conclusive and binding upon the Guarantor, and may be enforced in any courts to the
jurisdiction of which the Guarantor is subject by a suit upon such judgment, provided, that service of process is effected upon the Guarantor in the manner specified herein or as otherwise permitted by law. 

The Guarantor hereby irrevocably designates, appoints and empowers C T Corporation System, with offices at 111 Eighth Avenue, New York, New
York, as its designee, appointee and agent to receive, accept and acknowledge for and on its behalf, and its properties, assets and revenues, service for any and all legal process, summons, notices and documents which may be served in any action,
suit or proceeding brought in the courts listed above which may be made on 

  
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such designee, appointee and agent in accordance with legal procedures prescribed for such courts, with respect to any suit, action or proceeding in connection with or arising out of this Third
Supplemental Indenture or the Note Guarantee by the Guarantor. If for any reason such designee, appointee and agent hereunder shall cease to be available to act as such, such party agrees to designate a new designee, appointee and agent on the terms
and for the purposes of this Section 7 reasonably satisfactory to the Trustee. The Guarantor further hereby irrevocably consents and agrees to the service of any and all legal process, summons, notices and documents out of any of the aforesaid
courts in any such action, suit or proceeding by serving a copy thereof upon the agent for service of process referred to in this Section 7 (whether or not the appointment of such agent shall for any reason prove to be ineffective or such agent
shall accept or acknowledge such service) or by mailing copies thereof by registered or certified airmail, postage prepaid, to it at its address specified in or designated pursuant to this Third Supplemental Indenture. The Guarantor agrees that the
failure of any such designee, appointee and agent to give any notice of such service to it shall not impair or affect in any way the validity of such service or any judgment rendered in any action or proceeding based thereon. Nothing herein shall in
any way be deemed to limit the ability of the Holders or the Trustee to serve any such legal process, summons, notices and documents in any other manner permitted by applicable law or to obtain jurisdiction over the undersigned or bring actions,
suits or proceedings against the undersigned in such other jurisdictions, and in manner, as may be permitted by applicable law. 
 8.
Notices. Any request, demand, authorization, direction, notice, consent, waiver or Act of Holders or other document provided or permitted by this Second Supplemental Indenture to be made upon, given or furnished to, or filed with: 

(a) the Trustee by any Holder or by the Guarantor shall be sufficient for every purpose hereunder if made, given, furnished or filed in writing
to or with the Trustee at its Corporate Trust Office, Attention: Corporate Trust Division; or 
 (b) the Guarantor by the Trustee or by an
Holder shall be sufficient for every purpose hereunder (unless otherwise expressly provided) if in writing and mailed, first-class postage pre-paid, to the Guarantor addressed to it at the following address: 

Medtronic plc 
 20 Lower Hatch
Street 
 Dublin 2, Ireland 

Attention: General Counsel 

with a copy (which shall not constitute notice to the Guarantor) to: 

Medtronic, Inc. 
 710 Medtronic
Parkway 
 Minneapolis, Minnesota 55432-5604 

Attention: Treasury Department, Mail Stop LC480 

Fax number: (763) 505-2700 

E-mail: rs.corporatetreasury@medtronic.com 

  
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 9. Counterparts. The parties may sign any number of copies of this Third Supplemental
Indenture. Each signed copy shall be an original, but all of them together represent the same agreement. The exchange of copies of this Third Supplemental Indenture and of signature pages by facsimile or .pdf transmission shall constitute effective
execution and delivery of this Third Supplemental Indenture as to the parties hereto and may be used in lieu of the original Third Supplemental Indenture for all purposes. Signatures of the parties hereto transmitted by facsimile or .pdf shall be
deemed to be their original signatures for all purposes. 
 10. Headings. The headings of the Sections of this Third Supplemental
Indenture have been inserted for convenience of reference only, are not to be considered a part of this Third Supplemental Indenture and shall in no way modify or restrict any of the terms or provisions hereof. 

11. Trustee. The Trustee accepts the amendments of the Indenture effected by this Third Supplemental Indenture, but on the terms and
conditions set forth in the Indenture, including the terms and provisions defining and limiting the liabilities and responsibilities of the Trustee. Without limiting the generality of the foregoing, the Trustee shall not be responsible in any manner
whatsoever for or with respect to any of the recitals or statements contained herein, all of which recitals or statements are made solely by the Guarantor, or for or with respect to (i) the validity or sufficiency of this Third Supplemental
Indenture or any of the terms or provisions hereof, (ii) the proper authorization hereof by the Guarantor by action or otherwise, (iii) the due execution hereof by the Guarantor or (iv) the consequences of any amendment herein
provided for, and the Trustee makes no representation with respect to any such matters. 
 12. Successors. All agreements of the
Guarantor in this Third Supplemental Indenture shall bind its successors, except as otherwise provided in Section 14.01(f) of the Base Indenture, or elsewhere in the Indenture or this Third Supplemental Indenture. All agreements of the Trustee
in this Third Supplemental Indenture shall bind its successors. 
 [Signature Pages Follow] 

  
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 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly executed, all as of the
date first above written. 
  

			
	MEDTRONIC GLOBAL HOLDINGS S.C.A.,
	 as Guarantor
 a Luxembourg corporate
partnership limited by shares (société en commandite par actions) represented by

	Medtronic Global Holdings GP S.à r.l.
	Its General Partner, in turn acting by
		
	By:	 	/s/ Andrej Grossmann
	Name: Andrej Grossmann
	Title: Class A Manager
	
	AND
		
	By:	 	/s/ Linda Harty
	Name: Linda Harty
	Title: Class B Manager

 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly executed, all as of the
date first above written. 
  

			
	WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee
		
	By:	 	/s/ Raymond Delli Colli
	Name: Raymond Delli Colli
	Title: Vice PresidentEX-4.5

 Exhibit 4.5 

Execution Version 

REGISTRATION RIGHTS JOINDER AGREEMENT 

JANUARY 26, 2015 
 WHEREAS,
Medtronic, Inc., a Minnesota corporation (the “Company”) and the Representatives of the several Initial Purchasers named therein (the “Representatives”) heretofore executed and delivered a Purchase Agreement, dated
December 1, 2014 (the “Purchase Agreement”), providing for the issuance and sale of the Securities; and 
 WHEREAS, in
connection with the Purchase Agreement, the Company and the Representatives heretofore executed and delivered a Registration Rights Agreement, dated December 10, 2014 (the “Registration Rights Agreement”), pursuant to which the
Company agreed to file a registration statement with the Commission registering an exchange offer for the Securities and/or the resale of the Securities under the Securities Act; and 

WHEREAS, neither Medtronic public limited company, an Irish public limited company (“New Medtronic”), nor Medtronic Global Holdings,
S.C.A., a Luxembourg corporate partnership limited by shares (société en commandite par actions) (“Medtronic Luxco”) was originally a party thereto, but each has agreed to join in the Registration Rights Agreement (the
“Registration Rights Agreement”). 
 Capitalized terms used herein and not otherwise defined herein shall have the meanings
ascribed to such terms in the Purchase Agreement and the Registration Rights Agreement. 
 NOW, THEREFORE, each of New Medtronic and
Medtronic Luxco hereby agrees for the benefit of the Representatives, as follows: 
 1. Joinder. Each of the undersigned hereby
acknowledges that it has received and reviewed a copy of the Registration Rights Agreement and all other documents it deems fit in order to enter into this Registration Rights Joinder Agreement (the “Registration Rights Joinder
Agreement”), and acknowledges and agrees unconditionally and irrevocably (i) to join and become a party to the Registration Rights Agreement as indicated by its signature below as of the date hereof and shall have the same rights and
obligations thereunder as if it had been an original signatory to the Registration Rights Agreement; (ii) to be bound by all representations, warranties, agreements and obligations attributable to a Guarantor in the Registration Rights
Agreement as if made by, and with respect to, such undersigned in accordance with the terms of the Registration Rights Agreement as of the date hereof; and (iii) to perform all obligations and duties required of a Guarantor pursuant to the
Registration Rights Agreement. 
 2. Representations and Warranties and Agreements of each Guarantor. Each of the undersigned hereby
represents and warrants to and agrees with the Representatives that it has all requisite corporate power and authority to execute, 

 
deliver and perform its obligations under this Registration Rights Joinder Agreement and it has duly and validly taken all necessary action for the consummation of the transactions contemplated
hereby and by the Registration Rights Agreement and that it has duly authorized, executed and delivered this Registration Rights Joinder Agreement and it is a valid and legally binding agreement enforceable against such undersigned in accordance
with its terms. 
 3. Counterparts. This Registration Rights Joinder Agreement may be signed in one or more counterparts (which may be
delivered in original form or a facsimile or “pdf” file thereof), each of which shall constitute an original when so executed and all of which together shall constitute one and the same agreement. 

4. Amendments. No amendment or waiver of any provision of this Registration Rights Joinder Agreement, nor any consent or approval to any
departure therefrom, shall in any event be effective unless the same shall be in writing and signed by the parties thereto. 
 5.
Headings. The section headings used herein are for convenience only and shall not affect the construction hereof. 
 6.
Severability of Provisions. If any term or other provision of this Registration Rights Joinder Agreement is invalid, illegal or incapable of being enforced by any rule of law, or public policy, all other provisions of this Registration Rights
Joinder Agreement shall nevertheless remain in full force and effect so long as the economic or legal substance of the agreements contained herein is not affected in any manner adverse to any party. Upon such determination that any term or provision
is invalid, illegal or unenforceable, the parties hereto shall negotiate in good faith to modify this Registration Rights Joinder Agreement so as to effect the original intent of the parties as closely as possible in a mutually acceptable manner in
order that the agreements contained herein may be performed as originally contemplated to the fullest extent possible. 
 7. Applicable
Law. This Registration Rights Joinder Agreement and any claim, controversy or dispute arising under or related to this Registration Rights Joinder Agreement shall be governed by, and construed in accordance with, the laws of the State of New
York. 
 8. Submission to Jurisdiction. Each of New Medtronic and Medtronic Luxco hereby submits to the exclusive jurisdiction of the
U.S. federal and New York state courts in the Borough of Manhattan in The City of New York in any suit or proceeding arising out of or relating to this Registration Rights Joinder Agreement or the transactions contemplated hereby. Each of New
Medtronic and Medtronic Luxco waives any objection which it may now or hereafter have to the laying of venue of any such suit or proceeding in such courts. Each of New Medtronic and Medtronic Luxco agrees that final judgment in any such suit, action
or proceeding brought in such court shall be conclusive and binding upon it and may be enforced in any court to the 

  
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jurisdiction of which it is subject by a suit upon such judgment. New Medtronic irrevocably designates and appoints C T Corporation System, having an office on the date hereof at 111 Eighth
Avenue, New York, New York, and Medtronic Luxco irrevocably designates and appoints C T Corporation System, having an office on the date hereof at 111 Eighth Avenue, New York, New York, as its respective authorized agent upon which process may be
served in any such suit or proceeding (each, an “Authorized Agent”). Each of New Medtronic and Medtronic Luxco agrees that service of process upon such Authorized Agent, and written notice of such service to it at the address set forth
below, shall be deemed in every respect effective service of process upon New Medtronic or Medtronic Luxco, as applicable, in any such suit or proceeding. 

New Medtronic: 
 Medtronic plc

 20 Lower Hatch Street 

Dublin 2, Ireland 
 Attention:
General Counsel 
 with a copy (which shall not constitute notice to New Medtronic) to: 

Medtronic, Inc. 
 710 Medtronic
Parkway 
 Minneapolis, Minnesota 55432-5604 

Attention: Treasury Department, Mail Stop LC480 

Facsimile: (763) 505-2700 

E-mail: rs.corporatetreasury@medtronic.com 

Medtronic Luxco: 
 Medtronic
Global Holdings, S.C.A. 
 1, rue du Potager 

L-2347, Luxembourg, Grand Duchy of Luxembourg 

Attention: General Partner 

Facsimile: +352 24 611714 
 with a
copy (which shall not constitute notice to Medtronic Luxco) to: 
 Medtronic, Inc. 

710 Medtronic Parkway 

Minneapolis, Minnesota 55432-5604 

Attention: Treasury Department, Mail Stop LC480 

Facsimile: (763) 505-2700 

E-mail: rs.corporatetreasury@medtronic.com 

  
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 Each of New Medtronic or Medtronic Luxco hereby represents and warrants that such Authorized
Agent has accepted such appointment and has agreed to act as such authorized agent (or another such agent satisfactory to the Representatives) for service of process. 

[Signature page follows] 

  
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 IN WITNESS WHEREOF, the undersigned have executed this Registration Rights Joinder Agreement as
of the date first written above. 
  

			
	MEDTRONIC PLC
		
	By:	 	/s/ Gary L. Ellis
		 	Name: Gary L. Ellis
		 	Title: Lawfully appointed attorney
	
	 MEDTRONIC GLOBAL HOLDINGS S.C.A.
 a
Luxembourg corporate partnership limited by shares (société en commandite par actions) represented by
 Medtronic Global Holdings GP
S.à r.l.
 Its General Partner, in turn acting by

		
	By:	 	/s/ Andrej Grossmann
		 	Name: Andrej Grossmann
		 	Title: Class A Manager
	
	AND
		
	By:	 	/s/ Linda Harty
		 	Name: Linda Harty
		 	Title: Class B Manager

 The foregoing Registration Rights Joinder Agreement is hereby confirmed and accepted by the Initial Purchasers as
of the date first written above. 
  

			
	 MERRILL LYNCH, PIERCE, FENNER & SMITH

INCORPORATED

	
	DEUTSCHE BANK SECURITIES INC.
	
	J.P. MORGAN SECURITIES LLC
	
	For themselves and on behalf of the several Initial Purchasers listed in Schedule 1 hereto.
	
	 By: MERRILL LYNCH, PIERCE, FENNER & SMITH

INCORPORATED

		
	By	 	/s/ Douglas Muller
		 	Authorized Signatory
	
	By: DEUTSCHE BANK SECURITIES INC.
		
	By	 	/s/ John Han
		 	Authorized Signatory
		
	By	 	/s/ Anguel Zaprianov
		 	Authorized Signatory
	
	By: J.P. MORGAN SECURITIES LLC
		
	By	 	/s/ Robert Bottamedi
		 	Authorized Signatory

 [Registration Rights Joinder Agreement Signature Page]

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