Document:

Exhibit 10.1 

 

EXECUTION COPY

 

AMENDED
 & RESTATED 

EMPLOYMENT AGREEMENT

 

This
Amended & Restated Employment Agreement (“Agreement”) is between Blueprint Medicines Corporation, a Delaware corporation
(the “Company”), and Jeffrey W. Albers (the “Executive”) and is effective as of April 4, 2022 (the “Effective
Date”).

 

WHEREAS,
the Company and the Executive are parties to the Employment Agreement dated as of November 6, 2015, as amended by a first amendment thereto
dated as of December 22, 2021 (as amended, the “Original Employment Agreement”);

 

WHEREAS,
the Company and the Executive desire to enter into this Agreement effective as of the Effective Date to replace the Original Employment
Agreement, provided the Executive remains employed by the Company on the Effective Date; and

 

WHEREAS,
the Company desires to employ the Executive and the Executive desires to be employed by the Company on the terms and conditions contained
herein.

 

NOW,
THEREFORE, in consideration of the mutual covenants and agreements herein contained and other good and valuable consideration, the receipt
and sufficiency of which is hereby acknowledged, the parties agree as follows:

 

1.                
Employment.

 

(a)               
Term. The term of this Agreement shall commence on the Effective Date and continue until the earlier of (i) December 31, 2022
or (ii) the date that it is terminated in accordance with the provisions of Section 3 (the "Term"). Notwithstanding anything
to the contrary in this Agreement, the Executive’s employment with the Company will be “at will,” meaning that the
Executive’s employment may be terminated by the Company or the Executive at any time and for any reason, subject to the terms of
this Agreement. 

 

(b)              
Position and Duties. Effective as of the Effective Date, the Executive shall resign as the Company’s President and Chief
Executive Officer and shall serve on a part-time basis as the Company's Executive Chairman, reporting solely and directly to the Board
of Directors of the Company (the "Board"), and will devote approximately sixty percent (60%) of his full working time and efforts
to the business and affairs of the Company. As Executive Chairman, the Executive will be responsible for providing the Company with strategic
advice and services upon reasonable request by the Chief Executive Officer (“CEO”) and/or the Board, which may include matters
related to corporate strategy, business development, investor relations, corporate communications, commercial, and team leadership development
as well as specific transactions, initiatives, matters or projects as may be requested by the CEO and/or the Board from time to time.
In addition, during the Term, the Executive will continue to serve on the Board, to perform the functions of Chairman of the Board and
participate in Board meetings and sub-committees. The Executive acknowledges and agrees that his role as Executive Chairman may change
from time to time, and such changes shall not constitute “Good Reason” as defined herein unless they are made without his
consent and constitute a material diminution in the Executive’s responsibilities, authority or duties, in the aggregate, as Executive
Chairman. The Executive may engage in outside professional activities including by serving on other boards of directors, provided such
activities do not pose a conflict of interest and are approved in advance by the Board. The Executive may also engage in religious, charitable,
or other community activities as long as such services and activities do not materially interfere with the performance of his duties
to the Company as provided in this Agreement.

 

     

     

    

  

2.                
Compensation and Related Matters.

 

(a)              
Base Salary. Effective as of the Effective Date, the Executive's annualized base salary shall be $425,000. The Executive' s base
salary may be re-determined by the Board or the Compensation Committee of the Board (the “Compensation Committee”) from time
to time and shall be subject to increase but not decrease (other than for any mutually agreed-upon reduction in the amount of the Executive’s
time that will be devoted to the Company) while serving in the role of Executive Chairman. The annualized base salary in effect at any
given time is referred to herein as "Base Salary." The Base Salary shall be payable in a manner that is consistent with the
Company's usual payroll practices for senior executives.

 

(b)              
Equity. The Executive may be eligible to receive future equity awards under the Company’s 2015 Stock Option and Incentive
Plan (as amended and/or restated from time to time) or such other equity plan as then in effect, in the sole discretion of the Board
or the Compensation Committee of the Board. Further, for the avoidance of doubt, each of the Executive’s equity awards outstanding
as of the Effective Date will continue to vest following the Effective Date, for so long as the Executive continues to provide services
to the Company as an employee of the Company and/or as a member of the Board, subject to the terms of the applicable equity award agreement
and equity plan.

 

(c)              
Incentive Compensation. The Executive shall not be eligible to receive cash incentive compensation in connection with his service
as Executive Chairman during the Term unless otherwise determined by the Board or the Compensation Committee. In the event that the Board
or the Compensation determines to pay the Executive cash incentive compensation, the Executive must be an employee of the Company and/or
a member of the Board on the day such incentive compensation is paid. For the avoidance of doubt, notwithstanding anything to the contrary
herein:

 

(i)            
for the year that ended December 31, 2021, the Executive remains eligible to receive incentive compensation in connection with his services
as President and Chief Executive Officer of the Company during such year as determined by the Board or the Compensation Committee based
on the Executive’s target incentive compensation under the Original Employment Agreement as previously determined by the Compensation
Committee, provided the Executive remains employed by the Company on the day such incentive compensation is paid; and

 

(ii)           
for the period beginning on January 1, 2022 and ending on April 3, 2022 (inclusive), the Executive is eligible to earn prorated incentive
compensation under the Original Employment Agreement in connection with his services as President and Chief Executive Officer of the
Company during such period as determined by the Board or the Compensation Committee based on the Executive’s target incentive compensation
equal to 70% of his annual base salary as in effect during such period (and the Board or the Compensation Committee shall weigh its bonus
determination 100% on Company performance), provided the Executive remains a member of the Board on the day such incentive compensation
is paid.

 

(d)              
Expenses. The Executive shall be entitled to receive prompt reimbursement for all reasonable expenses incurred by him during the
Term in performing services hereunder, in accordance with the policies and procedures then in effect and established by the Company for
its senior executive officers.

 

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(e)              
Other Benefits. During the Term, the Executive shall be eligible to participate in or receive benefits under the Company's employee
benefit plans in effect from time to time, subject to the terms of such plans.

 

(f)               
Vacations. During the Term, the Executive shall be entitled to paid vacation in accordance with the Company's applicable policy.

 

3.               
Termination. The Executive’s employment hereunder will end on December 31, 2022, unless it is sooner terminated by the Company
or the Executive pursuant to this Section 3. During the Term, the Executive's employment hereunder may be terminated without any breach
of this Agreement under the following circumstances:

 

(a)              
Death. The Executive's employment hereunder shall terminate upon his death.

 

(b)             
Disability. The Company may terminate the Executive's employment if he is disabled and unable to perform the essential functions
of the Executive' s then existing position or positions under this Agreement with or without reasonable accommodation for a period of
180 days (which need not be consecutive) in any 12-month period. If any question shall arise as to whether during any period the Executive
is disabled so as to be unable to perform the essential functions of the Executive's then existing position or positions with or without
reasonable accommodation, the Executive may, and at the request of the Company shall, submit to the Company a certification in reasonable
detail by a physician selected by the Company to whom the Executive or the Executive's guardian has no reasonable objection as to whether
the Executive is so disabled or how long such disability is expected to continue, and such certification shall for the purposes of this
Agreement be conclusive of the issue. The Executive shall cooperate with any reasonable request of the physician in connection with such
certification. If such question shall arise and the Executive shall fail to submit such certification, the Company's determination of
such issue shall be binding on the Executive. Nothing in this Section 3(b) shall be construed to waive the Executive's rights, if any,
under existing law including, without limitation, the Family and Medical Leave Act of 1993, 29 U.S.C. §2601 et seq. and the
Americans with Disabilities Act, 42 U.S.C. §12101 et seq.

 

(c)             
Termination by Company for Cause. The Company may terminate the Executive's employment hereunder for Cause. For purposes of this
Agreement, "Cause" shall mean: (i) conduct by the Executive constituting a material act of misconduct in connection with the
performance of his duties, including, without limitation, misappropriation of funds or property of the Company or any of its subsidiaries
or affiliates other than the occasional, customary and de minimis use of Company property for personal purposes; (ii) the commission
by the Executive of any felony or a misdemeanor involving moral turpitude, deceit, dishonesty or fraud, or any conduct by the Executive
that would reasonably be expected to result in material injury or reputational harm to the Company or any of its subsidiaries and affiliates
if he were retained in his position; (iii) continued non-performance by the Executive of his duties hereunder (other than by reason of
the Executive's physical or mental illness, incapacity or disability) which has continued for more than 30 days following written notice
of such non-performance from the Board; (iv) a material breach by the Executive of any of the provisions contained in Section 7 of this
Agreement; (v) a material violation by the Executive of the Company's written employment policies; or (vi) failure to cooperate with
a bona fide internal investigation or an investigation by regulatory or law enforcement authorities, after being instructed by the Company
to cooperate, or the willful destruction or failure to preserve documents or other materials known to be relevant to such investigation
or the inducement of others to fail to cooperate or to produce documents or other materials in connection with such investigation.

 

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(d)              
Termination by the Company Without Cause. The Company may terminate the Executive's employment at any time without Cause. Any
termination by the Company of the Executive' s employment under this Agreement which does not constitute a termination for Cause under
Section 3(c) and does not result from the death or disability of the Executive under Section 3(a) or (b) shall be deemed a termination
by the Company without Cause.

 

(e)              
Termination by the Executive. The Executive may terminate his employment hereunder at any time for any reason, including but not
limited to Good Reason. For purposes of this Agreement, "Good Reason" shall mean that the Executive has complied with the "Good
Reason Process" (hereinafter defined) following the occurrence of any of the following events without the Executive's express written
consent: (i) a material diminution in the Executive' s responsibilities, authority or duties without the Executive' s consent; (ii) a
material diminution in the Executive's Base Salary without the Executive's consent (unless such diminution is in connection with a proportional
reduction in compensation to all or substantially all of the Company's employees); (iii) a material change of more than 50 miles in the
geographic location at which the Executive provides services to the Company; or (iv) the material breach of this Agreement by the Company.
 "Good Reason Process" shall mean that (i) the Executive reasonably determines in good faith that a "Good Reason"
condition has occurred; (ii) the Executive notifies the Company in writing of the first occurrence of the Good Reason condition within
60 days of the first occurrence of such condition; (iii) the Executive cooperates in good faith with the Company's efforts, for a period
not less than 30 days following such notice (the "Cure Period") to remedy the condition; (iv) notwithstanding such efforts,
the Good Reason condition continues to exist; and (v) the Executive terminates his employment within 60 days after the end of the Cure
Period. If the Company cures the Good Reason condition during the Cure Period, Good Reason shall be deemed not to have occurred.

 

(f)               
Notice of Termination. Except for termination as specified in Section 3(a), any termination of the Executive's employment by the
Company or any such termination by the Executive shall be communicated by written Notice of Termination to the other party hereto. For
purposes of this Agreement, a "Notice of Termination" shall mean a notice which shall indicate the specific termination provision
in this Agreement relied upon.

 

(g)             
Date of Termination. "Date of Termination" shall mean: (i) if the Executive's employment is terminated by his death,
the date of his death; (ii) if the Executive's employment is terminated on account of disability under Section 3(b) or by the Company
for Cause under Section 3(c), the date on which Notice of Termination is given; (iii) if the Executive's employment is terminated by
the Company under Section 3(d), the date on which a Notice of Termination is given; (iv) if the Executive's employment is terminated
by the Executive under Section 3(e) without Good Reason, 30 days after the date on which a Notice of Termination is given, and (v) if
the Executive's employment is terminated by the Executive under Section 3(e) with Good Reason, the date on which a Notice of Termination
is given after the end of the Cure Period. Notwithstanding the foregoing, in the event that the Executive gives a Notice of Termination
to the Company, the Company may unilaterally accelerate the Date of Termination and such acceleration shall not result in a termination
by the Company for purposes of this Agreement.

 

 

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(h)             
Consent to Amended and Restated Employment Agreement. The Executive hereby gives his express written consent to this Agreement
which amends and restates the Original Employment Agreement. Accordingly, the Executive acknowledges and agrees that none of the terms
hereof shall serve as the basis of a “Good Reason” trigger as defined in this Agreement or the Original Employment Agreement,
and therefore the Executive shall not be eligible to resign for Good Reason as a result of any terms, or in connection with the negotiation,
execution and delivery, of this Agreement.

 

4.                
Compensation Upon Termination.

 

(a)              
Termination Generally. If the Executive' s employment with the Company is terminated for any reason, the Company shall pay or
provide to the Executive (or to his authorized representative or estate) (i) any Base Salary earned through the Date of Termination,
unpaid expense reimbursements (subject to, and in accordance with, Section 2(c) of this Agreement) and, if applicable, unused vacation
that accrued through the Date of Termination on or before the time required by law but in no event more than 30 days after the Executive's
Date of Termination; and (ii) any vested benefits the Executive may have under any employee benefit plan of the Company through the Date
of Termination, which vested benefits shall be paid and/or provided in accordance with the terms of such employee benefit plans (collectively,
the "Accrued Benefit").

 

(b)             
Termination by the Company Without Cause or by the Executive with Good Reason. During the Term, if the Executive's employment
is terminated by the Company without Cause as provided in Section 3(d), or the Executive terminates his employment for Good Reason as
provided in Section 3(e), then the Company shall pay the Executive his Accrued Benefit. In addition, subject to (i) the Executive signing
a separation agreement containing, among other provisions, a general release of claims in favor of the Company and related persons and
entities, confidentiality, return of property and non-disparagement, and a noncompetition agreement with terms substantially similar
to the Restrictive Covenants Agreement (as defined below), and which shall provide that if the Executive breaches any provision of the
Restrictive Covenants Agreement or any other continuing obligations the Executive has to the Company, then all payments of the Severance
Amount shall immediately cease, in a form and manner satisfactory to the Company (the "Separation Agreement and Release") and
(ii) the Separation Agreement and Release becoming irrevocable, all within 60 days after the Date of Termination (or such shorter period
as set forth in the Separation Agreement and Release):

 

(i)               
the Company shall pay the Executive an amount equal to one (1) times the Executive's Base Salary (the "Severance Amount");
and

 

(ii)              
if the Executive was participating in the Company's group health (medical, dental and/or vision) plan immediately prior to the Date of
Termination and elects COBRA health continuation, then the Company shall pay to the Executive a monthly cash payment for twelve (12)
months or the Executive's COBRA health continuation period, whichever ends earlier, in an amount equal to the monthly employer contribution
that the Company would have made to provide health insurance to the Executive if the Executive had remained employed by the Company.

 

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The
amounts payable under this Section 4(b) shall be paid out in substantially equal installments in accordance with the Company's payroll
practice over twelve (12) months commencing within 60 days after the Date of Termination; provided, however, that if the 60-day period
begins in one calendar year and ends in a second calendar year, the Severance Amount shall begin to be paid in the second calendar year
by the last day of such 60-day period; provided, further, that the initial payment shall include a catch-up payment to cover amounts
retroactive to the day immediately following the Date of Termination. Each payment pursuant to this Agreement is intended to constitute
a separate payment for purposes of Treasury Regulation Section 1.409A-2(b)(2).

 

For
the avoidance of doubt, neither Section 4 nor Section 5 of this Agreement shall apply to the ending of the Executive’s employment
if the Term ends on December 31, 2022 in accordance with Section 1(a) of this Agreement. If the Executive’s employment ends on
December 31, 2022, then the Executive shall be entitled to the Accrued Benefit but shall not be entitled to any severance pay or benefits
under this Agreement or otherwise.

 

5.                
Sale Event Payment. The provisions of this Section 5 are intended to assure and encourage in advance the Executive's continued
attention and dedication to his assigned duties and his objectivity during the pendency and after the occurrence of any Sale Event (as
defined below). These provisions shall apply in lieu of, and expressly supersede, the provisions of Section 4(b) regarding severance
pay and benefits upon a termination of employment, if the Date of Termination occurs within twelve (12) months after the occurrence of
the first event constituting a Sale Event. These provisions shall terminate and be of no further force or effect beginning twelve (12)
months after the occurrence of a Sale Event.

 

(a)              
Sale Event. During the Term, if within twelve (12) months after a Sale Event, the Executive’s employment is terminated by
the Company without Cause as provided in Section 3(d) or the Executive terminates employment for Good Reason as provided in Section 3(e),
then, subject to the signing of the Separation Agreement and Release by the Executive and the Separation Agreement and Release becoming
irrevocable, all within 60 days after the Date of Termination (or such shorter period as set forth in the Separation Agreement and Release):

 

(i)                
the Company shall pay the Executive a lump sum in cash in an amount equal to one and one-half (1.5) times the Executive’s current
Base Salary (or the Executive’s Base Salary in effect immediately prior to the Sale Event, if higher) (the “Change in Control
Payment”); and

 

(ii)              
if the Executive was participating in the Company’s group health (medical, dental and/or vision) plan immediately prior to the
Date of Termination and elects COBRA health continuation, then the Company shall pay to the Executive a monthly cash payment for eighteen
(18) months or the Executive’s COBRA health continuation period, whichever ends earlier, in an amount equal to the monthly employer
contribution that the Company would have made to provide health insurance to the Executive if the Executive had remained employed by
the Company; and

 

(iii)             
all time-based stock options and other time-based stock-based awards held by the Executive shall accelerate and become fully exercisable
or non-forfeitable as of the Date of Termination; provided that, if any stock options or other
stock-based awards held by the Executive prior to the Effective Date have accelerated vesting terms that are more favorable to the
Executive than those set forth in this Section 5(a)(iii), the vesting terms of those stock options or other stock-based awards shall
apply as opposed to the accelerated vesting terms set forth in this Section 5(a)(iii), solely with respect to such awards.

 

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The
amounts payable under Section 5(a)(i) and (ii) shall be paid or commence to be paid within 60 days after the Date of Termination; provided
however, that if the 60-day period begins in one calendar year and ends in a second calendar year, such payment shall be paid or commence
to be paid in the second calendar year by the last day of such 60-day period.

 

(b)              
Additional Limitation.

 

(i)               
Anything in this Agreement to the contrary notwithstanding, in the event that the amount of any compensation, payment or distribution
by the Company to or for the benefit of the Executive, whether paid or payable or distributed or distributable pursuant to the terms
of this Agreement or otherwise, calculated in a manner consistent with Section 280G of the Internal Revenue Code of 1986, as amended
(the "Code") and the applicable regulations thereunder (the "Aggregate Payments"), would be subject to the excise
tax imposed by Section 4999 of the Code, then the Aggregate Payments shall be reduced (but not below zero) so that the sum of all of
the Aggregate Payments shall be $1.00 less than the amount at which the Executive becomes subject to the excise tax imposed by Section
4999 of the Code; provided that such reduction shall only occur if it would result in the Executive receiving a higher After Tax Amount
(as defined below) than the Executive would receive if the Aggregate Payments were not subject to such reduction. In such event, the
Aggregate Payments shall be reduced in the following order, in each case, in reverse chronological order beginning with the Aggregate
Payments that are to be paid the furthest in time from consummation of the transaction that is subject to Section 280G of the Code: (1)
cash payments not subject to Section 409A of the Code; (2) cash payments subject to Section 409A of the Code; (3) equity based payments
and acceleration; and (4) non-cash forms of benefits; provided that in the case of all the foregoing Aggregate Payments all amounts or
payments that are not subject to calculation under Treas. Reg. §l.280G-1, Q&A-24(b) or (c) shall be reduced before any amounts
that are subject to calculation under Treas. Reg. §1.280G-1, Q&A- 24(b) or (c).

 

(ii)              
For purposes of this Section 5(b), the "After Tax Amount" means the amount of the Aggregate Payments less all federal, state,
and local income, excise and employment taxes imposed on the Executive as a result of the Executive' s receipt of the Aggregate Payments.
For purposes of determining the After Tax Amount, the Executive shall be deemed to pay federal income taxes at the highest marginal rate
of federal income taxation applicable to individuals for the calendar year in which the determination is to be made, and state and local
income taxes at the highest marginal rates of individual taxation in each applicable state and locality, net of the maximum reduction
in federal income taxes which could be obtained from deduction of such state and local taxes.

 

(iii)             
The determination as to whether a reduction in the Aggregate Payments shall be made pursuant to Section 5(b)(i) shall be made by a nationally
recognized accounting firm selected by the Company (the "Accounting Firm"), which shall provide detailed supporting calculations
both to the Company and the Executive within 15 business days of the Date of Termination, if applicable, or at such earlier time as is
reasonably requested by the Company or the Executive. Any determination by the Accounting Firm shall be binding upon the Company and
the Executive.

  

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(c)              
Sale Event Definition. For purposes of this Section 5, "Sale Event" shall mean (i) the sale of all or substantially
all of the assets of the Company on a consolidated basis to an unrelated person or entity, (ii) a merger, reorganization or consolidation
pursuant to which the holders of the Company' s outstanding voting power and outstanding stock immediately prior to such transaction
do not own a majority of the outstanding voting power and outstanding stock or other equity interests of the resulting or successor entity
(or its ultimate parent, if applicable) immediately upon completion of such transaction, (iii) the sale of all of the Stock of the Company
to an unrelated person, entity or group thereof acting in concert, or (iv) any other transaction in which the owners of the Company's
outstanding voting power immediately prior to such transaction do not own at least a majority of the outstanding voting power of the
Company or any successor entity immediately upon completion of the transaction other than as a result of the acquisition of securities
directly from the Company. Notwithstanding the foregoing, if the definition of Sale Event in an option agreement or stock based award
agreement between the Executive and the Company dated prior to the Effective Date (each, a "Preexisting Equity Agreement")
is broader than this definition of Sale Event, the definition of Sale Event in such Preexisting Equity Agreement shall apply solely with
respect to the equity award covered by such Preexisting Equity Agreement.

 

Notwithstanding
the foregoing, a "Sale Event" shall not be deemed to have occurred for purposes of the foregoing clauses (ii) and (iv) solely
as the result of an acquisition of securities by the Company which, by reducing the number of shares of voting securities outstanding,
increases the proportionate number of voting securities beneficially owned by any person to 50 percent or more of the combined voting
power of all of the then outstanding voting securities; provided, however, that if any person referred to in this sentence shall thereafter
become the beneficial owner of any additional shares of voting securities (other than pursuant to a stock split, stock dividend, or similar
transaction or as a result of an acquisition of securities directly from the Company) and immediately thereafter beneficially owns 50
percent or more of the combined voting power of all of the then outstanding voting securities, then a "Sale Event" shall be
deemed to have occurred for purposes of the foregoing clauses (ii) and (iv).

 

6.                
Section 409A.

 

(a)              
Anything in this Agreement to the contrary notwithstanding, if at the time of the Executive's separation from service within the meaning
of Section 409A of the Code, the Company determines that the Executive is a "specified employee" within the meaning of Section
409A(a)(2)(B)(i) of the Code, then to the extent any payment or benefit that the Executive becomes entitled to under this Agreement on
account of the Executive's separation from service would be considered deferred compensation otherwise subject to the 20 percent additional
tax imposed pursuant to Section 409A(a) of the Code as a result of the application of Section 409A(a)(2)(B)(i) of the Code, such payment
shall not be payable and such benefit shall not be provided until the date that is the earlier of (A) six months and one day after the
Executive' s separation from service, or (B) the Executive's death. If any such delayed cash payment is otherwise payable on an installment
basis, the first payment shall include a catch-up payment covering amounts that would otherwise have been paid during the six-month period
but for the application of this provision, and the balance of the installments shall be payable in accordance with their original schedule.

 

(b)             
All in-kind benefits provided and expenses eligible for reimbursement under this Agreement shall be provided by the Company or incurred
by the Executive during the time periods set forth in this Agreement. All reimbursements shall be paid as soon as administratively practicable,
but in no event shall any reimbursement be paid after the last day of the taxable year following the taxable year in which the expense
was incurred. The amount of in-kind benefits provided or reimbursable expenses incurred in one taxable year shall not affect the in-kind
benefits to be provided or the expenses eligible for reimbursement in any other taxable year (except for any lifetime or other aggregate
limitation applicable to medical expenses). Such right to reimbursement or in-kind benefits is not subject to liquidation or exchange
for another benefit.

 

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(c)              
To the extent that any payment or benefit described in this Agreement constitutes "non-qualified deferred compensation" under
Section 409A of the Code, and to the extent that such payment or benefit is payable upon the Executive's termination of employment, then
such payments or benefits shall be payable only upon the Executive's "separation from service." The determination of whether
and when a separation from service has occurred shall be made in accordance with the presumptions set forth in Treasury Regulation Section
1.409A-1(h).

 

(d)             
The parties intend that this Agreement will be administered in accordance with Section 409A of the Code. To the extent that any provision
of this Agreement is ambiguous as to its compliance with Section 409A of the Code, the provision shall be read in such a manner so that
all payments hereunder comply with Section 409A of the Code. Each payment pursuant to this Agreement is intended to constitute a separate
payment for purposes of Treasury Regulation Section l.409A-2(b)(2). The parties agree that this Agreement may be amended, as reasonably
requested by either party, and as may be necessary to fully comply with Section 409A of the Code and all related rules and regulations
in order to preserve the payments and benefits provided hereunder without additional cost to either party.

 

(e)              
The Company makes no representation or warranty and shall have no liability to the Executive or any other person if any provisions of
this Agreement are determined to constitute deferred compensation subject to Section 409A of the Code but do not satisfy an exemption
from, or the conditions of, such Section.

 

7.                
Restrictive Covenants Agreement. The Executive hereby acknowledges and agrees that the terms of the Non-Solicitation, Non-Competition,
Confidentiality and Assignment Agreement, dated as of July 21, 2014, by and between the Company and the Executive (the "Restrictive
Covenants Agreement"), remain in full force and effect

 

8.                
Arbitration of Disputes. Any controversy or claim arising out of or relating to this Agreement or the breach thereof or otherwise
arising out of the Executive' s employment or the termination of that employment (including, without limitation, any claims of unlawful
employment discrimination whether based on age or otherwise) shall, to the fullest extent permitted by law, be settled by arbitration
in any forum and form agreed upon by the parties or, in the absence of such an agreement, under the auspices of the American Arbitration
Association ("AAA") in Boston, Massachusetts in accordance with the Employment Dispute Resolution Rules of the AAA, including,
but not limited to, the rules and procedures applicable to the selection of arbitrators. In the event that any person or entity other
than the Executive or the Company may be a party with regard to any such controversy or claim, such controversy or claim shall be submitted
to arbitration subject to such other person or entity's agreement. Judgment upon the award rendered by the arbitrator may be entered
in any court having jurisdiction thereof. This Section 8 shall be specifically enforceable. Notwithstanding the foregoing, this Section
8 shall not preclude either party from pursuing a court action for the sole purpose of obtaining a temporary restraining order or a preliminary
injunction in circumstances in which such relief is appropriate; provided that any other relief shall be pursued through an arbitration
proceeding pursuant to this Section 8.

 

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9.                
Consent to Jurisdiction. To the extent that any court action is permitted consistent with or to enforce Section 8 of this Agreement,
the parties hereby consent to the jurisdiction of the Superior Court of the Commonwealth of Massachusetts and the United States District
Court for the District of Massachusetts. Accordingly, with respect to any such court action, the Executive (a) submits to the personal
jurisdiction of such courts; (b) consents to service of process; and (c) waives any other requirement (whether imposed by statute, rule
of court, or otherwise) with respect to personal jurisdiction or service of process.

 

10.              
Integration. Effective as of the Effective Date, this Agreement constitutes the entire agreement between the parties with respect
to the subject matter hereof and supersedes all other prior agreements, written or oral, between the parties concerning such subject
matter (including without limitation any offer letter, the Original Employment Agreement, or any severance agreement); provided that
(i) the Restrictive Covenants Agreement and (ii) any equity award agreements entered into by the Company and the Executive prior to the
date hereof, in each case, are expressly preserved.

 

11.              
Withholding. All payments made by the Company to the Executive under this Agreement shall be net of any tax or other amounts required
to be withheld by the Company under applicable law.

 

12.             
Successor to the Executive. This Agreement shall inure to the benefit of and be enforceable by the Executive's personal representatives,
executors, administrators, heirs, distributees, devisees and legatees. In the event of the Executive's death after his termination of
employment but prior to the completion by the Company of all payments due him under this Agreement, the Company shall continue such payments
to the Executive's beneficiary designated in writing to the Company prior to his death (or to his estate, if the Executive fails to make
such designation).

 

13.              
Enforceability. If any portion or provision of this Agreement (including, without limitation, any portion or provision of any
section of this Agreement) shall to any extent be declared illegal or unenforceable by a court of competent jurisdiction, then the remainder
of this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so declared illegal
or unenforceable, shall not be affected thereby, and each portion and provision of this Agreement shall be valid and enforceable to the
fullest extent permitted by law.

 

14.              
Survival. The provisions of this Agreement shall survive the termination of this Agreement and/or the termination of the Executive's
employment to the extent necessary to effectuate the terms contained herein.

 

15.              
Waiver. No waiver of any provision hereof shall be effective unless made in writing and signed by the waiving party. The failure
of any party to require the performance of any term or obligation of this Agreement, or the waiver by any party of any breach of this
Agreement, shall not prevent any subsequent enforcement of such term or obligation or be deemed a waiver of any subsequent breach.

 

16.             
Notices. Any notices, requests, demands and other communications provided for by this Agreement shall be sufficient if in writing
and delivered in person or sent by a nationally recognized overnight courier service or by registered or certified mail, postage prepaid,
return receipt requested, to the Executive at the last address the Executive has filed in writing with the Company or, in the case of
the Company, at its main offices, attention of the Board.

 

17.             
Amendment. This Agreement may be amended or modified only by a written instrument signed by the Executive and by a duly authorized
representative of the Company.

 

    10

     

    

  

18.             
Governing Law. This is a Massachusetts contract and shall be construed under and be governed in all respects by the laws of the
Commonwealth of Massachusetts, without giving effect to the conflict of laws principles of such Commonwealth. With respect to any disputes
concerning federal law, such disputes shall be determined in accordance with the law as it would be interpreted and applied by the United
States Court of Appeals for the First Circuit.

 

19.              
Counterparts. This Agreement may be executed in any number of counterparts, each of which when so executed and delivered shall
be taken to be an original; but such counterparts shall together constitute one and the same document.

 

20.             
Successor to Company. The Company shall require any successor (whether direct or indirect, by purchase, merger, consolidation
or otherwise) to all or substantially all of the business or assets of the Company expressly to assume and agree to perform this Agreement
to the same extent that the Company would be required to perform it if no succession had taken place. Failure of the Company to obtain
an assumption of this Agreement at or prior to the effectiveness of any succession shall be a material breach of this Agreement.

 

[Signature
page follows.]

 

    11

     

    

  

IN
WITNESS WHEREOF, the parties have executed this Agreement effective as of the Effective Date.

  

	 	BLUEPRINT
    MEDICINES CORPORATION
	 	 
	 	By:	/s/
    Tracey McCain
	 	Name:	Tracey
    McCain
	 	Title:	Executive
    Vice President, Chief Legal and Compliance Officer
	 	Date:	January
    4, 2022
	 	 
	 	EXECUTIVE
	 	 
	 	/s/
    Jeffrey Albers
	 	Name:	Jeffrey
    Albers
	 	Date:	January
    4, 2022

 

[Signature
Page – Amended & Restated Employment Agreement]Exhibit 10.2

 

EXECUTION COPY

 

AMENDED & RESTATED 

EMPLOYMENT AGREEMENT

 

This Amended & Restated Employment Agreement
(“Agreement”) is between Blueprint Medicines Corporation, a Delaware corporation (the “Company”), and Kathryn
Haviland (the “Executive”) and is effective as of April 4, 2022 (the “Effective Date”).

 

WHEREAS, the Company and the Executive are parties
to the Employment Agreement dated as of March 10, 2016, as amended by the first amendment thereto dated as of January 30, 2019 and a second
amendment thereto dated as of December 22, 2021 (as amended, the “Original Employment Agreement”);

 

WHEREAS, the Company and the Executive desire to
enter into this Agreement effective as of the Effective Date to replace the Original Employment Agreement, provided the Executive is employed
by the Company on the Effective Date; and

 

WHEREAS, the Company desires to employ the Executive
and the Executive desires to be employed by the Company on the terms and conditions contained herein.

 

NOW, THEREFORE, in consideration of
the mutual covenants and agreements herein contained and other good and valuable consideration, the receipt and sufficiency of which is
hereby acknowledged, the parties agree as follows:

 

		1.	Employment.

 

(a)              Term.
The term of this Agreement shall commence on the Effective Date and continue until terminated in accordance with the provisions of Section
3 (the "Term"). Notwithstanding anything to the contrary in this Agreement, the Executive’s employment with the Company
will be “at will,” meaning that the Executive’s employment may be terminated by the Company or the Executive at any
time and for any reason, subject to the terms of this Agreement.

 

(b)             Position and Duties. Effective as of the Effective Date, the Executive shall resign as the Chief Business Officer
and shall serve as the President and Chief Executive Officer (“CEO”) of the Company and shall have supervision and control
over and responsibility for the day-to-day business and affairs of the Company and shall have such other powers and duties as may from
time to time be prescribed by the Board of Directors of the Company (the “Board”), provided that such duties are consistent
with the Executive’s position as CEO. In addition, the Company shall cause the Executive to be nominated for election to the Board
and to be recommended to the stockholders for election to the Board as long as the Executive remains the CEO, provided that the Executive
shall be deemed to have resigned from the Board and from any related positions upon ceasing to serve as CEO for any reason. The Executive
shall devote her full working time and efforts to the business and affairs of the Company. Notwithstanding the foregoing, the Executive
may serve on other boards of directors, with the approval of the Board, or engage in religious, charitable or other activities as long
as such services and activities are approved by the Board and do not materially interfere with the Executive’s performance of her
duties to the Company as provided in this Agreement.

 

     

     

    

 

		2.	Compensation and Related Matters.

 

(a)              Base Salary. Effective as of the Effective Date, the Executive’s annualized base salary shall be $745,000. The Executive’s
base salary shall be re-determined annually by the Board or the Compensation Committee of the Board (the “Compensation Committee”)
and shall be subject to increase but not decrease while the Executive is serving in the CEO role. The annualized base salary in effect
at any given time is referred to herein as the “Base Salary.” The Base Salary shall be payable in a manner that is consistent
with the Company’s usual payroll practices for senior executives.

 

(b)             
Equity. The Executive may be eligible to receive future equity awards under the Company’s 2015 Stock Option and Incentive
Plan (as amended and/or restated from time to time) or such other equity plan as then in effect, in the sole discretion of the Board or
the Compensation Committee.

 

(c)             
Incentive Compensation. During the Term, the Executive shall be eligible to receive cash incentive compensation as determined
by the Board or the Compensation Committee from time to time. The Executive’s target annual incentive compensation shall be 70%
of her Base Salary (the “Target Incentive Compensation”). The Board or the Compensation Committee shall weigh its bonus
determination as follows: 100% on Company performance. To earn incentive compensation, the Executive must
be employed by the Company on the day such incentive compensation is paid. For the avoidance of doubt, notwithstanding anything to the
contrary herein:

 

(i)                
for the year that ended December 31, 2021, the Executive is eligible to receive incentive compensation in connection with her services
as Chief Operating Officer of the Company during such year as determined by the Board or the Compensation Committee based on the Executive’s
target incentive compensation under the Original Employment Agreement as previously determined by the Compensation Committee, provided
the Executive remains employed by the Company on the day such incentive compensation is paid; and

 

(ii)              
for the period beginning on January 1, 2022 and ending on April 3, 2022 (inclusive), the Executive is eligible to earn prorated
incentive compensation under the Original Employment Agreement in connection with her services as Chief Operating Officer of the Company
during such period as determined by the Board or the Compensation Committee based on the Executive’s target incentive compensation
equal to 60% of her annual base salary as in effect during such period (and Board or the Compensation Committee shall weigh its
bonus determination 75% on Company performance and 25% on Executive’s individual performance), provided
the Executive remains employed by the Company on the day such incentive compensation is paid.

 

(d)             
Expenses. The Executive shall be entitled to receive prompt reimbursement for all reasonable expenses incurred by her during
the Term in performing services hereunder, in accordance with the policies and procedures then in effect and established by the Company
for its senior executive officers.

 

(e)              
Other Benefits. During the Term, the Executive shall be eligible to participate in or receive benefits under the Company's
employee benefit plans in effect from time to time, subject to the terms of such plans.

 

    -2- 

     

    

 

(f)              Vacations. During the Term, the Executive shall be entitled to paid vacation in accordance with the Company's applicable
policy.

 

3.               Termination.
During the Term, the Executive's employment hereunder may be terminated without any breach of this Agreement under the following circumstances:

 

(a)             
Death. The Executive' s employment hereunder shall terminate upon her death.

 

(b)             
Disability. The Company may terminate the Executive's employment if she is disabled and unable to perform the essential
functions of the Executive' s then existing position or positions under this Agreement with or without reasonable accommodation for a
period of 180 days (which need not be consecutive) in any 12-month period. If any question shall arise as to whether during any period
the Executive is disabled so as to be unable to perform the essential functions of the Executive's then existing position or positions
with or without reasonable accommodation, the Executive may, and at the request of the Company shall, submit to the Company a certification
in reasonable detail by a physician selected by the Company to whom the Executive or the Executive ' s guardian has no reasonable objection
as to whether the Executive is so disabled or how long such disability is expected to continue, and such certification shall for the purposes
of this Agreement be conclusive of the issue. The Executive shall cooperate with any reasonable request of the physician in connection
with such certification. If such question shall arise and the Executive shall fail to submit such certification, the Company's determination
of such issue shall be binding on the Executive. Nothing in this Section 3(b) shall be construed to waive the Executive's rights, if any,
under existing law including, without limitation, the Family and Medical Leave Act of 1993, 29 U.S.C. §2601 et seq. and the
Americans with Disabilities Act, 42 U.S.C. §12101 et seq.

 

(c)              Termination by Company for Cause. The Company may terminate the Executive's employment hereunder for Cause. For purposes
of this Agreement, "Cause" shall mean: (i) conduct by the Executive constituting a material act of misconduct in connection
with the performance of her duties, including, without limitation, misappropriation of funds or property of the Company or any of its
subsidiaries or affiliates other than the occasional, customary and de minimis use of Company property for personal purposes; (ii) the
commission by the Executive of any felony or a misdemeanor involving moral turpitude, deceit, dishonesty or fraud, or any conduct by the
Executive that would reasonably be expected to result in material injury or reputational harm to the Company or any of its subsidiaries
and affiliates if she were retained in her position; (iii) continued non-performance by the Executive of her duties hereunder (other than
by reason of the Executive's physical or mental illness, incapacity or disability) which has continued for more than 30 days following
written notice of such non-performance from the Board; (iv) a material breach by the Executive of any of the provisions contained in Section
7 of this Agreement; (v) a material violation by the Executive of the Company's written employment policies; or (vi) failure to cooperate
with a bona fide internal investigation or an investigation by regulatory or law enforcement authorities, after being instructed by the
Company to cooperate, or the willful destruction or failure to preserve documents or other materials known to be relevant to such investigation
or the inducement of others to fail to cooperate or to produce documents or other materials in connection with such investigation.

 

    -3- 

     

    

 

(d)             Termination by the Company Without Cause. The Company may terminate the Executive's employment at any time without Cause.
Any termination by the Company of the Executive's employment under this Agreement which does not constitute a termination for Cause under
Section 3(c) and does not result from the death or disability of the Executive under Section 3(a) or (b) shall be deemed a termination
by the Company without Cause.

 

(e)              Termination
by the Executive. The Executive may terminate her employment hereunder at any time for any reason, including but not limited to Good
Reason. For purposes of this Agreement, "Good Reason" shall mean that the Executive has complied with the "Good Reason
Process" (hereinafter defined) following the occurrence of any of the following events without the Executive's express written consent:
(i) a material diminution in the Executive's responsibilities, authority or duties without the Executive's consent; (ii) a material diminution
in the Executive's Base Salary and/or Target Incentive Compensation without the Executive's consent (unless such diminution is in connection
with a proportional reduction in compensation to all or substantially all of the Company's employees); (iii) a material change of more
than 50 miles in the geographic location at which the Executive provides services to the Company; or (iv) the material breach of this
Agreement by the Company. "Good Reason Process" shall mean that (i) the Executive reasonably determines in good faith that
a "Good Reason" condition has occurred; (ii) the Executive notifies the Company in writing of the first occurrence of the Good
Reason condition within 60 days of the first occurrence of such condition; (iii) the Executive cooperates in good faith with the Company's
efforts, for a period not less than 30 days following such notice (the "Cure Period") to remedy the condition; (iv) notwithstanding
such efforts, the Good Reason condition continues to exist; and (v) the Executive terminates her employment within 60 days after the
end of the Cure Period. If the Company cures the Good Reason condition during the Cure Period, Good Reason shall be deemed not to have
occurred.

 

(f)              
Notice of Termination. Except for termination as specified in Section 3(a), any termination of the Executive's employment
by the Company or any such termination by the Executive shall be communicated by written Notice of Termination to the other party hereto.
For purposes of this Agreement, a "Notice of Termination" shall mean a notice which shall indicate the specific termination
provision in this Agreement relied upon.

 

(g)              Date
of Termination. "Date of Termination" shall mean: (i) if the Executive's employment is terminated by her death, the date
of her death; (ii) if the Executive' s employment is terminated on account of disability under Section 3(b) or by the Company for Cause
under Section 3(c), the date on which Notice of Termination is given; (iii) if the Executive' s employment is terminated by the Company
under Section 3(d), the date on which a Notice of Termination is given; (iv) if the Executive's employment is terminated by the Executive
under Section 3(e) without Good Reason, 30 days after the date on which a Notice of Termination is given, and (v) if the Executive's
employment is terminated by the Executive under Section 3(e) with Good Reason, the date on which a Notice of Termination is given after
the end of the Cure Period. Notwithstanding the foregoing, in the event that the Executive gives a Notice of Termination to the Company,
the Company may unilaterally accelerate the Date of Termination and such acceleration shall not result in a termination by the Company
for purposes of this Agreement.

 

(h)              Consent
to Amended and Restated Employment Agreement. The Executive hereby gives her express written consent to this Agreement which
amends and restates the Original Employment Agreement. Accordingly, the Executive acknowledges and agrees that none of the terms
hereof shall serve as the basis of a “Good Reason” trigger as defined in this Agreement or the Original Employment
Agreement, and therefore the Executive shall not be eligible to resign for Good Reason as a result of any terms, or in connection
with the negotiation, execution and delivery, of this Agreement.

 

    -4- 

     

    

 

4.                Compensation Upon Termination.

 

(a)              Termination
Generally. If the Executive's employment with the Company is terminated for any reason, the Company shall pay or provide to the Executive
(or to her authorized representative or estate) (i) any Base Salary earned through the Date of Termination, unpaid expense reimbursements
(subject to, and in accordance with, Section 2(c) of this Agreement) and, if applicable, unused vacation that accrued through the Date
of Termination on or before the time required by law but in no event more than 30 days after the Executive's Date of Termination; and
(ii) any vested benefits the Executive may have under any employee benefit plan of the Company through the Date of Termination, which
vested benefits shall be paid and/or provided in accordance with the terms of such employee benefit plans (collectively, the "Accrued
Benefit").

 

(b)             Termination
by the Company Without Cause or by the Executive with Good Reason. During the Term, if the Executive's employment is terminated by
the Company without Cause as provided in Section 3(d), or the Executive terminates her employment for Good Reason as provided in Section
3(e), then the Company shall pay the Executive her Accrued Benefit. In addition, subject to (i) the Executive signing a separation agreement
containing, among other provisions, a general release of claims in favor of the Company and related persons and entities, confidentiality,
return of property and non-disparagement, and a noncompetition agreement with terms substantially similar to the Restrictive Covenants
Agreement (as defined below), and which shall provide that if the Executive breaches any provision of the Restrictive Covenants Agreement
or any other continuing obligations the Executive has to the Company, then all payments of the Severance Amount shall immediately cease,
such separation agreement to be in a form and manner satisfactory to the Company (the "Separation Agreement and Release") and
(ii) the Separation Agreement and Release becoming irrevocable, all within 60 days after the Date of Termination (or such shorter period
as set forth in the Separation Agreement and Release):

 

(i)                
the Company shall pay the Executive an amount equal to one (1) times the Executive's Base Salary (the "Severance Amount");
and

 

(ii)              
if the Executive was participating in the Company's group health (medical, dental and/or vision) plan immediately prior to the
Date of Termination and elects COBRA health continuation, then the Company shall pay to the Executive a monthly cash payment for twelve
(12) months or the Executive's COBRA health continuation period, whichever ends earlier, in an amount equal to the monthly employer contribution
that the Company would have made to provide health insurance to the Executive if the Executive had remained employed by the Company.

 

The amounts payable under this Section 4(b) shall be paid out in
substantially equal installments in accordance with the Company's payroll practice over twelve (12) months commencing within 60 days
after the Date of Termination; provided, however, that if the 60-day period begins in one calendar year and ends in a second
calendar year, the Severance Amount shall begin to be paid in the second calendar year by the last day of such 60-day period;
provided, further, that the initial payment shall include a catch-up payment to cover amounts retroactive to the day immediately
following the Date of Termination. Each payment pursuant to this Agreement is intended to constitute a separate payment for purposes
of Treasury Regulation Section l .409A-2(b)(2).

 

    -5- 

     

    

 

5.               Sale Event Payment. The provisions of this Section 5 are intended to assure and encourage in advance the Executive's continued
attention and dedication to her assigned duties and her objectivity during the pendency and after the occurrence of any Sale Event (as
defined below). These provisions shall apply in lieu of, and expressly supersede, the provisions of Section 4(b) regarding severance pay
and benefits upon a termination of employment, if the Date of Termination occurs within twelve (12) months after the occurrence of the
first event constituting a Sale Event. These provisions shall terminate and be of no further force or effect beginning twelve (12) months
after the occurrence of a Sale Event.

 

(a)              Sale Event. During the Term, if within twelve (12) months after a Sale Event, the Executive’s employment is terminated
by the Company without Cause as provided in Section 3(d) or the Executive terminates employment for Good Reason as provided in Section
3(e), then, subject to the signing of the Separation Agreement and Release by the Executive and the Separation Agreement and Release becoming
irrevocable, all within 60 days after the Date of Termination (or such shorter period as set forth in the Separation Agreement and Release):

 

(i)                
the Company shall pay the Executive a lump sum in cash in an amount equal to the sum of (A) two (2) times the Executive’s
current Base Salary (or the Executive’s Base Salary in effect immediately prior to the Sale Event, if higher) plus (B) two (2) times
the Executive’s Target Incentive Compensation ((A) and (B) together, the “Change in Control Payment”); and

 

(ii)              
if the Executive was participating in the Company’s group health (medical, dental and/or vision) plan immediately prior to
the Date of Termination and elects COBRA health continuation, then the Company shall pay to the Executive a monthly cash payment for twenty-four
(24) months or the Executive’s COBRA health continuation period, whichever ends earlier, in an amount equal to the monthly employer
contribution that the Company would have made to provide health insurance to the Executive if the Executive had remained employed by the
Company; and

 

(iii)            
all time-based stock options and other time-based stock-based awards held by the Executive shall accelerate and become fully exercisable
or non-forfeitable as of the Date of Termination; provided that, if any stock options or other stock-based awards held by the Executive
prior to the Effective Date have accelerated vesting terms that are more favorable to the Executive than those set forth in this Section
5(a)(iii), the vesting terms of those stock options or other stock-based awards shall apply as opposed to the accelerated vesting terms
set forth in this Section 5(a)(iii) solely with respect to such awards.

 

The amounts payable under Section 5(a)(i) and (ii) shall
be paid or commence to be paid within 60 days after the Date of Termination; provided however, that if the 60-day period begins in one
calendar year and ends in a second calendar year, such payment shall be paid or commence to be paid in the second calendar year by the
last day of such 60-day period.

 

    -6- 

     

    

 

(b)              Additional Limitation.

 

(i)                
Anything in this Agreement to the contrary notwithstanding, in the event that the amount of any compensation, payment or distribution
by the Company to or for the benefit of the Executive, whether paid or payable or distributed or distributable pursuant to the terms of
this Agreement or otherwise, calculated in a manner consistent with Section 280G of the Internal Revenue Code of 1986, as amended (the
 "Code") and the applicable regulations thereunder (the "Aggregate Payments"), would be subject to the excise tax imposed
by Section 4999 of the Code, then the Aggregate Payments shall be reduced (but not below zero) so that the sum of all of the Aggregate
Payments shall be $1.00 less than the amount at which the Executive becomes subject to the excise tax imposed by Section 4999 of the Code;
provided that such reduction shall only occur if it would result in the Executive receiving a higher After Tax Amount (as defined below)
than the Executive would receive if the Aggregate Payments were not subject to such reduction. In such event, the Aggregate Payments shall
be reduced in the following order, in each case, in reverse chronological order beginning with the Aggregate Payments that are to be paid
the furthest in time from consummation of the transaction that is subject to Section 280G of the Code: (1) cash payments not subject to
Section 409A of the Code; (2) cash payments subject to Section 409A of the Code; (3) equity- based payments and acceleration; and (4)
non-cash forms of benefits ; provided that in the case of all the foregoing Aggregate Payments all amounts or payments that are not subject
to calculation under Treas. Reg. §1.280G-1, Q&A-24(b) or (c) shall be reduced before any amounts that are subject to calculation
under Treas. Reg. §1.280G -1, Q&A- 24(b) or (c).

 

(ii)              
For purposes of this Section 5(b), the "After Tax Amount" means the amount of the Aggregate Payments less all federal,
state, and local income, excise and employment taxes imposed on the Executive as a result of the Executive's receipt of the Aggregate
Payments. For purposes of determining the After Tax Amount, the Executive shall be deemed to pay federal income taxes at the highest marginal
rate of federal income taxation applicable to individuals for the calendar year in which the determination is to be made, and state and
local income taxes at the highest marginal rates of individual taxation in each applicable state and locality, net of the maximum reduction
in federal income taxes which could be obtained from deduction of such state and local taxes.

 

(iii)            
The determination as to whether a reduction in the Aggregate Payments shall be made pursuant to Section 5(b)(i) shall be made by
a nationally recognized accounting firm selected by the Company (the "Accounting Firm"), which shall provide detailed supporting
calculations both to the Company and the Executive within 15 business days of the Date of Termination, if applicable, or at such earlier
time as is reasonably requested by the Company or the Executive. Any determination by the Accounting Firm shall be binding upon the Company
and the Executive.

 

(c)              Sale
Event Definitions. For purposes of this Section 5, "Sale Event" shall mean (i) the sale of all or substantially all of
the assets of the Company on a consolidated basis to an unrelated person or entity, (ii) a merger, reorganization or consolidation
pursuant to which the holders of the Company's outstanding voting power and outstanding stock immediately prior to such transaction
do not own a majority of the outstanding voting power and outstanding stock or other equity interests of the resulting or successor
entity (or its ultimate parent, if applicable) immediately upon completion of such transaction, (iii) the sale of all of the Stock
of the Company to an unrelated person, entity or group thereof acting in concert, or (iv) any other transaction in which the owners
of the Company's outstanding voting power immediately prior to such transaction do not own at least a majority of the outstanding
voting power of the Company or any successor entity immediately upon completion of the transaction other than as a result of the
acquisition of securities directly from the Company. Notwithstanding the foregoing, if the definition of Sale Event in an option
agreement or stock-based award agreement between the Executive and the Company dated prior to the Effective Date (each, a
 "Preexisting Equity Agreement") is broader than this definition of Sale Event, the definition of Sale Event in such
Preexisting Equity Agreement shall apply solely with respect to the equity award covered by such Preexisting Equity Agreement.

 

    -7- 

     

    

 

Notwithstanding the foregoing, a "Sale Event" shall not be
deemed to have occurred for purposes of the foregoing clauses (ii) and (iv) solely as the result of an acquisition of securities by the
Company which, by reducing the number of shares of voting securities outstanding, increases the proportionate number of voting securities
beneficially owned by any person to 50 percent or more of the combined voting power of all of the then outstanding voting securities;
provided, however, that if any person referred to in this sentence shall thereafter become the beneficial owner of any additional shares
of voting securities (other than pursuant to a stock split, stock dividend, or similar transaction or as a result of an acquisition of
securities directly from the Company) and immediately thereafter beneficially owns 50 percent or more of the combined voting power of
all of the then outstanding voting securities, then a "Sale Event" shall be deemed to have occurred for purposes of the foregoing
clauses (ii) and (iv).

 

		6.	Section 409A.

 

(a)              Anything
in this Agreement to the contrary notwithstanding, if at the time of the Executive's separation from service within the meaning of Section
409A of the Code, the Company determines that the Executive is a "specified employee" within the meaning of Section 409A(a)(2)(B)(i)
of the Code, then to the extent any payment or benefit that the Executive becomes entitled to under this Agreement on account of the
Executive's separation from service would be considered deferred compensation otherwise subject to the 20 percent additional tax imposed
pursuant to Section 409A(a) of the Code as a result of the application of Section 409A(a)(2)(B)(i) of the Code, such payment shall not
be payable and such benefit shall not be provided until the date that is the earlier of (A) six months and one day after the Executive'
s separation from service, or (B) the Executive' s death. If any such delayed cash payment is otherwise payable on an installment basis,
the first payment shall include a catch-up payment covering amounts that would otherwise have been paid during the six-month period but
for the application of this provision, and the balance of the installments shall be payable in accordance with their original schedule.

 

(b)              All
in-kind benefits provided and expenses eligible for reimbursement under this Agreement shall be provided by the Company or incurred
by the Executive during the time periods set forth in this Agreement. All reimbursements shall be paid as soon as administratively
practicable, but in no event shall any reimbursement be paid after the last day of the taxable year following the taxable year in
which the expense was incurred. The amount of in-kind benefits provided or reimbursable expenses incurred in one taxable year shall
not affect the in-kind benefits to be provided or the expenses eligible for reimbursement in any other taxable year (except for any
lifetime or other aggregate limitation applicable to medical expenses). Such right to reimbursement or in-kind benefits is not
subject to liquidation or exchange for another benefit.

 

    -8- 

     

    

 

(c)              To the extent that any payment or benefit described in this Agreement constitutes "non-qualified deferred compensation"
under Section 409A of the Code, and to the extent that such payment or benefit is payable upon the Executive' s termination of employment,
then such payments or benefits shall be payable only upon the Executive' s "separation from service." The determination of whether
and when a separation from service has occurred shall be made in accordance with the presumptions set forth in Treasury Regulation Section
l.409A-l(h).

 

(d)              The parties intend that this Agreement will be administered in accordance with Section 409A of the Code. To the extent that any
provision of this Agreement is ambiguous as to its compliance with Section 409A of the Code, the provision shall be read in such a manner
so that all payments hereunder comply with Section 409A of the Code. Each payment pursuant to this Agreement is intended to constitute
a separate payment for purposes of Treasury Regulation Section 1.409A-2(b)(2). The parties agree that this Agreement may be amended, as
reasonably requested by either party, and as may be necessary to fully comply with Section 409A of the Code and all related rules and
regulations in order to preserve the payments and benefits provided hereunder without additional cost to either party.

 

(e)              The
Company makes no representation or warranty and shall have no liability to the Executive or any other person if any provisions of this
Agreement are determined to constitute deferred compensation subject to Section 409A of the Code but do not satisfy an exemption from,
or the conditions of, such Section.

 

7.            Restrictive
Covenants Agreement. The Executive hereby acknowledges and agrees that the terms of the Non-Solicitation, Non-Competition, Confidentiality
and Assignment Agreement, dated as of December 11, 2015, by and between the Company and the Executive (the "Restrictive Covenants
Agreement"), remain in full force and effect

 

8.            Arbitration
of Disputes. Any controversy or claim arising out of or relating to this Agreement or the breach thereof or otherwise arising out
of the Executive' s employment or the termination of that employment (including, without limitation, any claims of unlawful employment
discrimination whether based on age or otherwise) shall, to the fullest extent permitted by law, be settled by arbitration in any forum
and form agreed upon by the parties or, in the absence of such an agreement, under the auspices of the American Arbitration Association
("AAA") in Boston, Massachusetts in accordance with the Employment Dispute Resolution Rules of the AAA, including, but not
limited to, the rules and procedures applicable to the selection of arbitrators. In the event that any person or entity other than the
Executive or the Company may be a party with regard to any such controversy or claim, such controversy or claim shall be submitted to
arbitration subject to such other person or entity' s agreement. Judgment upon the award rendered by the arbitrator may be entered in
any court having jurisdiction thereof. This Section 8 shall be specifically enforceable. Notwithstanding the foregoing, this Section
8 shall not preclude either party from pursuing a court action for the sole purpose of obtaining a temporary restraining order or a preliminary
injunction in circumstances in which such relief is appropriate; provided that any other relief shall be pursued through an arbitration
proceeding pursuant to this Section 8.

 

    -9- 

     

    

 

9.            Consent to Jurisdiction. To the extent that any court action is permitted consistent with or to enforce Section 8 of this
Agreement, the parties hereby consent to the jurisdiction of the Superior Court of the Commonwealth of Massachusetts and the United States
District Court for the District of Massachusetts. Accordingly, with respect to any such court action, the Executive (a) submits to the
personal jurisdiction of such courts; (b) consents to service of process; and (c) waives any other requirement (whether imposed by statute,
rule of court, or otherwise) with respect to personal jurisdiction or service of process.

 

10.          Integration.
Effective as of the Effective Date, this Agreement constitutes the entire agreement between the parties with respect to the subject matter
hereof and supersedes all other prior agreements, written or oral, between the parties concerning such subject matter (including without
limitation any offer letter, the Original Employment Agreement, or any severance agreement); provided that (i) the Restrictive Covenants
Agreement and (ii) any equity award agreements entered into by the Company and the Executive prior to the date hereof, in each case,
are expressly preserved.

 

11.          Withholding.
All payments made by the Company to the Executive under this Agreement shall be net of any tax or other amounts required to be withheld
by the Company under applicable law.

 

12.          Successor
to the Executive. This Agreement shall inure to the benefit of and be enforceable by the Executive' s personal representatives, executors,
administrators, heirs, distributees, devisees and legatees. In the event of the Executive's death after her termination of employment
but prior to the completion by the Company of all payments due her under this Agreement, the Company shall continue such payments to
the Executive's beneficiary designated in writing to the Company prior to her death (or to her estate, if the Executive fails to make
such designation).

 

13.          Enforceability. If any portion or provision of this Agreement (including, without limitation, any portion or provision of
any section of this Agreement) shall to any extent be declared illegal or unenforceable by a court of competent jurisdiction, then the
remainder of this Agreement, or the application of such portion or provision in circumstances other than those as to which it is so declared
illegal or unenforceable, shall not be affected thereby, and each portion and provision of this Agreement shall be valid and enforceable
to the fullest extent permitted by law.

 

14.          Survival. The provisions of this Agreement shall survive the termination of this Agreement and/or the termination of the
Executive's employment to the extent necessary to effectuate the terms contained herein.

 

15.          Waiver. No waiver of any provision hereof shall be effective unless made in writing and signed by the waiving party. The
failure of any party to require the performance of any term or obligation of this Agreement, or the waiver by any party of any breach
of this Agreement, shall not prevent any subsequent enforcement of such term or obligation or be deemed a waiver of any subsequent breach.

 

16.          Notices.
Any notices, requests, demands and other communications provided for by this Agreement shall be sufficient if in writing and
delivered in person or sent by a nationally recognized overnight courier service or by registered or certified mail, postage
prepaid, return receipt requested, to the Executive at the last address the Executive has filed in writing with the Company or, in
the case of the Company, at its main offices, attention of the Board.

 

    -10- 

     

    

 

17.          Amendment.
This Agreement may be amended or modified only by a written instrument signed by the Executive and by a duly authorized representative
of the Company.

 

18.          Governing Law. This is a Massachusetts contract and shall be construed under and be governed in all respects by the laws
of the Commonwealth of Massachusetts, without giving effect to the conflict of laws principles of such Commonwealth. With respect to any
disputes concerning federal law, such disputes shall be determined in accordance with the law as it would be interpreted and applied by
the United States Court of Appeals for the First Circuit.

 

19.          Counterparts.
This Agreement may be executed in any number of counterparts, each of which when so executed and delivered shall be taken to be an original;
but such counterparts shall together constitute one and the same document.

 

20.          Successor to Company. The Company shall require any successor (whether direct or indirect, by purchase, merger, consolidation
or otherwise) to all or substantially all of the business or assets of the Company expressly to assume and agree to perform this Agreement
to the same extent that the Company would be required to perform it if no succession had taken place. Failure of the Company to obtain
an assumption of this Agreement at or prior to the effectiveness of any succession shall be a material breach of this Agreement.

 

[Signature page follows.]

 

    -11- 

     

    

 

IN WITNESS WHEREOF, the parties have executed this
Agreement effective as of the Effective Date.

 

	 	BLUEPRINT MEDICINES CORPORATION
	 	 
	 	By:	/s/ Jeffrey Albers
	 	Name:	Jeffrey Albers
	 	Title:	President and Chief Executive Officer
	 	Date:	January 4, 2022
	 	 
	 	EXECUTIVE
	 	 
	 	/s/ Kathryn Haviland
	 	Name:	Kathryn Haviland
	 	Date:	January 4, 2022

 

[Signature Page – Amended & Restated Employment Agreement]

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