Document:

EX-10.22

 Exhibit 10.22 

Adicet Bio, Inc. 
 September 4, 2019

 Francesco Galimi, M.D. Ph.D. 
  

	Re:	 Employment Offer 

Dear Francesco, 
 Adicet Bio, Inc., a Delaware
corporation (the “Company”), is pleased to make you an offer of employment on the following terms and conditions: 

1.    Position and Duties. You will serve as Chief Medical Officer and shall perform such duties as
are ordinary, customary and necessary in such role. You will report initially to the Company’s Chief Executive Officer and thereafter to such person as the Company may designate. Your start date with the Company shall be September 23,
2019, or such earlier date as agreed to by you and the Company’s Chief Executive Officer. You shall devote your full business time, skill and attention to the performance of your duties on behalf of the Company. Without the prior written
consent of the Company’s Chief Executive Officer, you will not engage in other employment or in any activities that could interfere with the performance of your duties or your availability to perform such duties or that will adversely affect,
or negatively reflect upon, the Company or that would be detrimental to the interests of the Company. 

2.    Compensation and Benefits. 

 

	 	a)	 Salary. The Company agrees to pay you an annual salary of $385,000
(“Base Salary”), less all required deductions and withholdings, payable as earned in accordance with the Company’s customary payroll practices.  

 

	 	b)	 Performance Bonus. You will be eligible to earn an annual performance bonus of up to 35% of your Base
Salary, based on achievement of performance targets established by the Company. The amount of any such bonus will be determined in the sole discretion of the Company. You must be employed with the Company on the date such bonus is paid in order to
be eligible for any bonus payment. Such bonus will be pro-rated for any partial year of employment. 

  

	 	c)	 Sign-on Bonus. The Company agrees to pay you a sign-on bonus of $325,000 in the aggregate, less all required deductions and withholdings (the “Sign-On Bonus”), which
Sign-On Bonus shall be payable in two tranches and subject to the following terms: 

The initial tranche of the Sign-On Bonus shall be for $162,500, less all required deductions and
withholdings, and shall be payable upon your first payroll in accordance with the Company’s customary payroll practices. 
 The final
tranche of the Sign-On Bonus shall be the remaining sum of $162,500, 

  
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less all required deductions and withholdings, and shall be payable within 45 days of the six (6) month anniversary of your start date in accordance with the Company’s customary payroll
practices. 
 To receive the final tranche of the Sign-On Bonus, you must be employed with the
Company on the six (6) month anniversary of your start date. You agree to repay (i) the full amount of your Sign-On Bonus to the Company if you voluntarily terminate your employment prior to the
twelve (12) month anniversary of your start date and (ii) 50% of your Sign-On Bonus to the Company if you voluntarily terminate your employment on or after the twelve (12) month anniversary of your
start date and prior to the twenty-four (24) month anniversary of your start date. 
  

	 	d)	 Stock Options. Subject to approval of the Company’s Board of Directors (the
“Board”), you will receive an option to purchase 1,035,685 shares of the Company’s common stock (the “Option”) pursuant to the Company’s 2015 Stock Incentive Plan. The per share exercise price of
the Option will be equal to the per share fair market value of the Company’s common stock on the date of grant, as determined by the Board. The Option will be contingent upon you executing the Company’s standard stock option agreement. So
long as you continue in service with the Company, the Option will vest and become exercisable with respect to 25% of the shares subject to the Option on the one-year anniversary of your start date, and with
respect to the balance, in thirty-six (36) equal monthly installments upon your completion of each additional month of service thereafter. 

 

	 	e)	 Benefits. You will be eligible to participate in regular health insurance, vacation, and other employee
benefit plans established by the Company for its employees from time to time on substantially the same terms as are made available to employees of the Company generally, provided you are eligible under (and subject to all provisions of) the plan
documents governing those plans. 

  

	 	f)	 Commuting and Lodging Expenses. The Company will provide a fully taxable reimbursement for reasonable
travel and lodging expense of up to $6,000 per month (for up to two years from your start date), less all required deductions and withholdings, related to your travel back and forth from San Diego, California to the San Francisco Bay Area to provide
services under this letter agreement, upon submission of proper vouchers and documentation in accordance with the Company’s expense reimbursement policy. 

 

	 	g)	 Other Expenses. The Company will reimburse you for all other reasonable and necessary expenses incurred
by you in connection with the Company’s business, in accordance with any applicable policy established by the Company from time to time. 

3.    At-Will Employment. You will be an “at-will” employee of the Company, which means that the employment relationship can be terminated by either you or the Company for any reason, at any time, with or without prior notice and with or without
cause. Any 

  
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statements or representations to the contrary should be regarded by you as ineffective. Any modification or change in the at-will employment status may
only occur by way of a written agreement signed by you and the Company’s Chief Executive Officer. 

4.    Severance. 
  

	 	a)	 Severance. Except in situations where your employment is terminated (1) by the Company for Cause
(as defined below) or as a result of your death or Disability (as defined below), or (2) by you other than for Good Reason (as defined below), you will be eligible to receive the following severance benefits (collectively, the
“Severance Benefits”): 

  

	 	i.	 An amount equal to six (6) months of your then-current Base Salary, less standard withholdings for tax and
social security purposes, payable in one lump sum within seventy (70) days following the date of termination of employment on the first payroll date following the date the Release (as defined below) becomes irrevocable (with the first payment
including any installments that otherwise would have been paid between the date of termination and the date of such first installment); provided, however, that, to the extent that the payment of any amount constitutes “nonqualified deferred
compensation” for purposes of Section 409A of the Internal Revenue Code of 1986, as amended (the “Code”) and related Treasury regulations (“Section 409A”), if the seventy (70) day
period described above spans calendar years, the payments will commence in the second calendar year. 

  

	 	ii.	 Subject to your timely election under COBRA, reimbursement of your COBRA premiums pursuant to the
Company’s normal expense reimbursement policy for six (6) months following the date of the termination of your employment (not to exceed the applicable continuation period) or, if earlier, until such time as you become eligible for similar
coverage through another employer. You will thereafter be responsible for the payment of COBRA premiums (including, without limitation, all administrative expenses) for any remaining COBRA period. Notwithstanding the foregoing, in the event that the
Company determines, in its sole discretion, that the Company may be subject to a tax or penalty pursuant to applicable law, including, but not limited to, Section 4980D of the Code as a result of providing some or all of the payments described
in this section, the Company may reduce or eliminate its obligations under this section to the extent it deems necessary, with no offset or other consideration required. 

 

	 	iii.	 If such termination of employment occurs within twelve months following a Liquidation (as defined in the
Company’s Amended and Restated Certificate of Incorporation, as amended, modified or restated from time to time), the vesting of all unvested restricted stock, options or other equity incentive awards then held by you shall be accelerated such
that all such restricted stock, options or other equity awards shall be deemed vested in full. 

  
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	 	b)	 Eligibility. Your eligibility for the Severance Benefits is conditioned on you having first
signed a release agreement in substantially the form attached as Exhibit B (the “Release”), which may be adjusted by the Company in its discretion for changes in applicable laws, rules or regulations or customary practice,
and such Release becoming effective pursuant to its terms no later than sixty (60) days following the date of termination of your employment (the “Release Deadline”). If the Release does not become effective and irrevocable by
the Release Deadline, you forfeit any rights to the Severance Benefits described in this Section 4. In no event will any Severance Benefits be paid under this Section 4 until the Release becomes effective and irrevocable and the Severance
Benefits will commence or be provided once the Release becomes effective and irrevocable. You agree that the Company shall have a right of offset against all severance payments for amounts owed to the Company by you (unless the amounts owed are
subject to a good faith dispute) to the fullest extent not prohibited by law. The Severance Benefits shall be in lieu of any other severance payments, severance benefits and severance protections to which you may be entitled under any severance or
termination policy, plan, program, practice or arrangement of the Company and its affiliates. Except as specifically provided in this Section 4 or in another section of this letter agreement, or except as required by law, all compensation and
benefits provided by the Company to you under this letter agreement or otherwise shall cease as of the date of termination of your employment. You shall not be entitled to any Severance Benefits if your employment is terminated (1) by the
Company for Cause or as a result of your death or Disability, or (2) by you other than for Good Reason. 

  

	 	c)	 Certain Tax Provisions. It is intended that the terms of this offer of employment comply with
Section 409A or an exemption therefrom, and the terms of this offer of employment will be interpreted accordingly; provided, however, that the Company, its affiliates, and their respective employees, officers, directors, agents and
representatives (including, without limitation, legal counsel) will not have any liability to you with respect to any taxes, penalties, interest or other costs or expenses you or any related party may incur with respect to or as a result of
Section 409A or for damages for failing to comply with Section 409A. Notwithstanding any provision to the contrary in this offer of employment, with respect to any amounts under this offer of employment that are determined to be deferred
compensation for purposes of Section 409A and payable as a result of the your termination of employment, you shall not be deemed to have terminated employment unless and until you have experienced a “separation from service” (as that
term is used in Section 409A). Payments pursuant to this offer of employment are intended to constitute separate payments for purposes of Treasury Regulation Section 1.409A-2(b)(2)(i) and payments of
continued salary pursuant to Section 4(a)(i) are intended to constitute a series of separate payments for purposes of Treasury Regulation Section 1.409A-2(b)(2)(iii). Any

  
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reimbursements or in-kind benefits provided to you or for your benefit that constitute deferred compensation for purposes of Section 409A shall be
provided in a manner that complies with Treasury Regulation Section 1.409A-3(i)(v). Accordingly, (i) all such reimbursements will be made not later than the last day of the calendar year after the
calendar year in which the expenses were incurred, (ii) any right to such reimbursements or in-kind benefits will not be subject to liquidation or exchange for another benefit, and (iii) the amount
of the expenses eligible for reimbursement, or the amount of any in-kind benefit provided, during any taxable year will not affect the amount of expenses eligible for reimbursement, or the in-kind benefits provided, in any other taxable year. 

  

	 	d)	 Certain Definitions. For purposes of this letter agreement: 

 

	 	i.	 “Cause” shall mean: (A) performance of any act or failure to perform any act in bad faith
and to the detriment of the Company or its affiliates, including, but not limited to, misappropriation of trade secrets, fraud or embezzlement; (B) material breach of any agreement with the Company or its affiliates; (C) commission of a
crime involving dishonesty, breach of trust, or physical or emotional harm to any person, (D) your willful refusal to implement or follow a lawful policy or directive of the Company or its affiliates; or (E) your engagement in misfeasance
or malfeasance demonstrated by a pattern of failure to perform job duties diligently and professionally. 

  

	 	ii.	 “Disability” means disability as defined under the long-term disability policy of the Company
regardless of whether you are covered by such policy. If the Company does not have a long-term disability plan in place, “Disability” means that, in the sole opinion of the Company, you are unable to carry out the responsibilities and
functions of the position you hold by reason of any medically determinable physical or mental impairment for a period of not less than ninety (90) consecutive days or more than one hundred and twenty days (120) in any twelve-month period.

  

	 	iii.	 “Good Reason” means any of the following events if (A) such event is affected without
your consent, (B) you provide written notice to the Company that such event constitutes Good Reason within thirty (30) days of the occurrence thereof, (C) you provide the Company with a period of twenty (20) days to cure such
event, and (D) the Company fails to cure such event within that period: (1) a change in your position with the Company which materially and substantially reduces your level of responsibility or duties; provided, however, that if the
Company is being acquired and made part of a larger entity, a change in your position shall not constitute Good Reason if such change does not result in a material and substantial reduction in your level of responsibility or duties with respect to
the Company’s business operations (whether as a subsidiary, 

  
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business unit, division or otherwise of the acquirer) following such acquisition; (2) a material reduction in your Base Salary, except for reductions that are comparable to reductions
generally applicable to similarly situated executives of the Company; or (3) a relocation of your principal place of employment by more than seventy five (75) miles from the Company’s current headquarters. 

5.    Representations and Warranties. You hereby represent and warrant as follows: 

 

	 	a)	 Neither your execution and delivery of this letter agreement nor the performance of your duties and other
obligations hereunder violate or will violate any statute or law or conflict with or constitute a default or breach of any covenant or obligation, including without limitation any non-competition restrictions,
under any prior employment agreement, contract, or other instrument to which you are a party or by which you are bound (whether immediately, upon the giving of notice or lapse of time or both). 

 

	 	b)	 You have the full right, power and legal capacity to enter and deliver this letter agreement and to perform
your duties and other obligations hereunder. This letter agreement constitutes the legal, valid and binding obligation of you enforceable against you in accordance with its terms. No approvals or consents of any persons or entities are required for
you to execute and deliver this letter agreement or perform your duties and other obligations hereunder. 

6.    Conditions to Employment. This offer of employment is contingent upon, and your employment
shall be subject to you: 
  

	 	a)	 Executing the Company’s form of Employee Proprietary Information and Invention Assignment Agreement
attached hereto as Exhibit A, which, among other things, prohibits unauthorized use or disclosure of the Company’s proprietary information; 

  

	 	b)	 Satisfying the requirements of the Immigration Control and Reform Act of 1986, which may be accomplished by
showing your proof of right to work in the U.S. within three days of commencing employment (e.g., an original driver’s license and social security card, or a passport); and 

 

	 	c)	 Satisfactorily completing a background check investigation. 

Notwithstanding anything to the contrary, this offer may be withdrawn by the Company at any time by the Company’s Chief Executive Officer
prior to the execution of this letter agreement by you. 
 Please indicate your acceptance to the foregoing terms by signing this letter
agreement where indicated below and returning it to me not later than September 7, 2019. This letter agreement sets forth our entire agreement and understanding regarding the terms of your employment with the Company and supersedes any prior
representations or agreements, whether written or oral. This letter agreement may not be modified in any way except in a writing signed by an officer of the Company and you. 

  
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 We look forward to you accepting our offer and becoming part of the Company’s team.

  

			
	Best regards,
	
	Adicet Bio, Inc.
		
	By:	 	 /s/ Carrie Krehlik

	Name:	 	Carrie Krehlik
	Title:	 	Sr. Vice President & Chief HR Officer

  

			
	AGREED TO AND ACCEPTED BY:
		
	By:	 	 /s/ Francesco Galimi

	Name:	 	Francesco Galimi, M.D. Ph.D.
		
	Date:	 	September 5, 2019

  
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 EXHIBIT A 

EMPLOYEE PROPRIETARY INFORMATION AND INVENTION
ASSIGNMENT AGREEMENTEX-10.23

 Exhibit 10.23 

AMENDMENT TO 

OFFER LETTER 

This AMENDMENT TO OFFER LETTER (this “Amendment”) is made
as of April 25, 2020 by and between Adicet Bio, Inc., a Delaware corporation (the “Company”), and Francesco Galimi (“Executive”). 

RECITALS 

WHEREAS, the Company and Executive are parties to that certain Offer Letter, dated as of
September 4, 2019, by and between the Company and Executive, as amended, modified or restated from time to time (the “Offer Letter”), and believe that it is in the best interests of the parties to amend the Offer Letter as
provided herein. 
 NOW THEREFORE, in consideration of the foregoing recitals and the
mutual agreements contained herein, the Company and Executive, intending to be legally bound hereby, agree as follows: 

1.1    Definitions; Construction. Capitalized terms not otherwise defined herein shall have the meanings set forth
in the Offer Letter. Any direct or indirect references in the Offer Letter to “this letter agreement” shall be deemed to be references to the Offer Letter as amended hereby. 

1.2    Amendment to Section 2.f. Section 2.f. of the Offer Letter shall be amended by
deleting such section in its entirety and replacing it with the following: 

“f.    Commuting and Lodging Expenses; Relocation Reimbursement. The Company will
provide a fully taxable reimbursement for reasonable travel and lodging expense of up to $6,000 per month (for up to two years from your start date), less all required deductions and withholdings, related to your travel back and forth from San
Diego, California to the San Francisco Bay Area to provide services under this letter agreement, upon submission of proper vouchers and documentation in accordance with the Company’s expense reimbursement policy (“Commuting
Expenses”). If, during the term of your employment, you choose to relocate permanently to the San Francisco Bay Area (a “Permanent Relocation”), the Company will make a fully taxable lump sum payment to you to cover
Reasonable Moving Expenses (as defined below) of up to a maximum of $60,000 (the “Relocation Reimbursement”); provided, however, that if you are terminated for Cause (as defined below) or resign other than for Good Reason (as
defined below) within six (6) months of such Relocation Reimbursement, you shall repay to the Company such Relocation Reimbursement. The Relocation Reimbursement shall be paid within thirty (30) days after you have submitted to the Company
such documentation supporting such reimbursement as is required under the Company’s generally applicable policies regarding same. Following any Permanent Relocation, you shall no longer be eligible for reimbursement of any Commuting Expenses.
For purposes of this letter agreement, “Reasonable Moving Expenses” shall mean your actual out of pocket expenses (but not, for the avoidance of doubt, any loss on sale, real 

 
estate-related taxes or attorneys’ fees) related to (A) the disposition of your then current principal residence, (B) relocation of your principal residence to a location within
seventy-five (75) miles of your then current principal place of work for the Company, (C) house-hunting trips related to such relocation and (D) other moving expenses incurred to relocate your household goods, furnishings, and
personal belongings from your then current residence to your new residence.” 
 1.3    Miscellaneous. Except
as specifically set forth herein, all of the terms and provisions of the Offer Letter shall remain unchanged, unmodified and in full force and effect, and the Offer Letter shall be read together and construed with this Amendment. This Amendment may
be executed in any number of counterparts, all of which taken together shall constitute one and the same amendatory instrument and any of the parties hereto may execute this Amendment by signing one counterpart. Any signature page delivered by
facsimile or e-mail transmission of images in Adobe PDF or similar format shall be binding to the same extent as an original signature page, with regard to any agreement subject to the terms hereof or any
amendment thereto. This Amendment, together with the Offer Letter as amended hereby and the documents referred to therein, shall supersede and replace any prior agreement between the Company and Executive relating to the subject matter hereof. This
Amendment is to be construed in accordance with and governed by the internal laws of the State of California without giving effect to any choice of law rule that would cause the application of the laws of any jurisdiction other than the internal
laws of the State of California to the rights and duties of the parties. The parties hereby irrevocably and unconditionally (i) submit to the jurisdiction of the federal and state courts located within the geographical boundaries of the United
States District Court for the Northern District of California for the purpose of any suit, action or other proceeding arising out of or based upon this Amendment, (ii) agree not to commence any suit, action or other proceeding arising out of or
based upon this Amendment except in the federal and state courts located within the geographical boundaries of the United States District Court for the Northern District of California, and (iii) hereby waive, and agree not to assert, by way of
motion, as a defense, or otherwise, in any such suit, action or proceeding, any claim that it is not subject personally to the jurisdiction of the above-named courts, that its property is exempt or immune from attachment or execution, that the suit,
action or proceeding is brought in an inconvenient forum, that the venue of the suit, action or proceeding is improper or that this Amendment or the subject matter hereof may not be enforced in or by such court. 

[Remainder of Page Intentionally Left Blank] 

  
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 IN WITNESS WHEREOF, the
parties have executed this Amendment as of the date first above written. 
  

			
	COMPANY:
	
	ADICET BIO, INC.
		
	By:	 	 /s/ Anil Singhal

	Name:	 	Anil Singhal
	Title:	 	CEO

 SIGNATURE PAGE TO AMENDMENT TO

 OFFER LETTER 

 
			
	EXECUTIVE:
	
	FRANCESCO GALIMI
		
	By:	 	 /s/ Francesco Galimi

	Name:	 	Francesco Galimi

 SIGNATURE PAGE TO AMENDMENT TO

 OFFER LETTER

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