Document:

CONFIDENTIAL TREATMENT REQUESTED. Confidential portions of this document have been redacted and have been
separately filed with the Commission. 

Exhibit 10.15

 

 

AMENDED AND
RESTATED EXCLUSIVE LICENSE AGREEMENT – IL-13

 

THIS AMENDED AND RESTATED EXCLUSIVE LICENSE
AGREEMENT – IL-13 (the “Agreement”) is made and entered into as of the 17th day of February,
2017 (the “A&R Effective Date”) by and between Mustang Bio, Inc. (f/k/a Mustang Therapeutics, Inc.),
a Delaware corporation with a principal place of business at 2 Gansevoort, 9th Floor, New York, NY 10014 (“Licensee”)
and City of Hope, a California nonprofit public benefit corporation located at 1500 East Duarte Road, Duarte, California 91010
(“City of Hope” or “COH”). Licensee and COH are each sometimes referred to herein individually
as a “Party” and collectively as the “Parties.”

 

WHEREAS:

 

A.           COH
operates an academic research and medical center that encourages the use of its inventions, discoveries and intellectual property
for the benefit of the public, and COH owns or Controls (as defined below) certain IL-13 Patent Rights (as defined below) useful
in the Field (as defined below);

 

B.           The
inventions covered by the IL-13 Patent Rights were invented by Dr. Stephen Forman who, as of the A&R Effective Date, is affiliated
with COH;

 

C.           The
research was sponsored in part by the National Institute of Health, and as a consequence this license is subject to obligations
to the United States Federal Government under 35 U.S.C. §§ 200-212 and applicable U.S. government regulations;

 

D.           The
research was sponsored in part by a grant from the California Institute for Regenerative Medicine (the “CIRM Grant”),
and as a consequence this Agreement is subject to applicable law and other obligations as applicable to exclusive licensees under
the CIRM Grant; 

 

E.           Licensee
is a company dedicated to the commercial development and exploitation in the Field (as defined below) of products and services
that incorporate one or more of the technologies described in the IL-13 Patent Rights and therefore Licensee desires to obtain
from COH a worldwide, exclusive license under the IL-13 Patent Rights, on the terms and subject to the conditions set forth herein;

 

F.           The
Certificate of Incorporation of Licensee as of the A&R Effective Date is in the form attached hereto as Exhibit A (the
“Charter”) and provides, among other things, for the rights and preferences of a class of stock, referred to
therein as Class A Common Stock, that was issued to COH or its designee(s) in accordance with the terms of the Original Agreement;

 

G.           COH
and Licensee have entered into (i) that certain Exclusive License Agreement, dated March 17, 2015 (the “Original Effective
Date”) (said agreement hereafter referred to as the “Original Agreement”), whereby COH granted to
Licensee certain exclusive rights in certain patent rights related to IL-13, CD123, and spacer technologies, and (ii) that certain
Sponsored Research Agreement between the Parties dated March 2015 (the “Research Agreement”); and

 

     

     

    

 

CONFIDENTIAL

 

H.           COH
and Licensee now desire to amend and restate the Original Agreement, which related to certain chimeric antigen receptor (“CAR”)
technologies in connection with IL-13, CD123, and spacer technologies by entering into three separate amended and restated exclusive
license agreements, one relating to CD123 (the “A&R CD123 License”), one relating to the spacer (the
“A&R Spacer License”), and one relating to IL-13 (this Agreement), that will also include certain rights
to certain CTA Inventions (defined below) and Study Data (defined below), amend the Original Agreement in certain other respects,
and collectively replace the Original Agreement in its entirety.

 

NOW, THEREFORE, in consideration of
the mutual covenants contained herein, and for other good and valuable consideration, the amount and sufficiency of which are hereby
acknowledged, the Parties hereby agree as follows:

 

ARTICLE
1: DEFINITIONS

 

1.1           “Act”
means the Securities Act of 1933, as amended.

 

1.2           “Affiliate”
of a Party means a Person that, directly or indirectly (through one or more intermediaries) controls, is controlled by, or is under
common control with such Party. For purposes of this Section 1.2, “control” means (i) the direct or indirect ownership
of 50 percent or more of the voting stock or other voting interests or interests in profits, or (ii) the ability to otherwise control
or direct the decisions of board of directors or equivalent governing body thereof.

 

1.3           “Business
Day” means any day, other than a Saturday, Sunday or day on which commercial banks located in Los Angeles, California,
are authorized or required by law or regulation to close.

 

1.4           “Change
of Control” means (i) any transaction or series of related transactions following which the holders of Licensee’s
capital stock immediately prior to such transaction or series of related transactions collectively are the owners of less than
50% of the outstanding equity interests of Licensee entitled to (a) vote with respect to the election of directors (or positions
having a similar function) or (b) receive the proceeds upon any sale, liquidation or dissolution of Licensee, (ii) a sale, transfer,
exclusive license or other disposition, in a single transaction or series of related transactions, of all or a material portion
of Licensee’s interest in the Licensed Product or Licensed Service or (iii) a sale, transfer, exclusive license or other
disposition, in a single transaction or series of related transactions, of all or a material portion of Licensee’s right
title, or interest in its assets taken as a whole.

 

1.5           “Class
A Common Stock” means Class A Common Stock, par value $0.0001 per share, of Licensee, with such rights preferences
and privileges as are set forth in the Charter.

 

1.6           “COH
CAR” means a CAR that is licensed to Licensee by COH pursuant to an applicable license agreement between the Parties,
including but not limited to, pursuant to this Agreement and the A&R CD123 License.

 

    	 	2	 

     

    

 

CONFIDENTIAL

 

1.7           “COH
Confidential Information” means Confidential Information disclosed or provided by, or on behalf of, COH to Licensee
or its designees.

 

1.8           “COH
Shares” means the shares of Class A Common Stock issued and to be issued to COH Stockholders in accordance with Section
4.3 of the Original Agreement and this Agreement and/or the terms of the Charter.

 

1.9           “COH
Spacer Technology” means any spacer, hinge, or linker sequence(s) that is used to connect the extracellular ligand-binding
domain to transmembrane and intracellular-signaling domains of an applicable CAR and that is covered by a Valid Claim under the
Spacer Patent Rights.

 

1.10         “Commercially
Reasonable Efforts” means the exercise of such efforts and commitment of such resources by Licensee, directly or
through one or more Sublicensees, in a diligent manner consistent with organizations in the pharmaceutical industry for a comparable
development or commercialization program at a similar stage of development or commercialization. In the event that Licensee or
a Sublicensee with respect to a given Licensed Product or Licensed Service, has a program or product that competes with the programs
contemplated by this Agreement with respect to such Licensed Product or Licensed Service, then “Commercially Reasonable Efforts”
shall also mean efforts at least comparable to those efforts and resources expended by Licensee or its Sublicensee on the competing
program and/or product or service.

 

1.11         “Completion”
means, with respect to a particular clinical trial, the earlier of (i) the database lock or freeze related to the completion of
treatment or examination of participants in such clinical trial or (ii) the dosing of the first patient in a clinical trial in
a subsequent phase (e.g., with respect to a Phase 1 Clinical Trial, the Phase 1 Clinical Trial will be deemed completed in the
event a patient is dosed in a Phase 2 Clinical Trial before a database lock in the related Phase 1 Clinical Trial).

 

1.12         “Common
Stock” means Common Stock, par value $0.0001 per share, of Licensee.

 

1.13         “Confidential
Information” means: (i) all information and materials (of whatever kind and in whatever form or medium) disclosed
by or on behalf of a Party to the other Party (or its designee) in connection with this Agreement, whether prior to or during the
term of this Agreement and whether provided orally, electronically, visually, or in writing; provided that all such information
and materials initially disclosed in writing or electronically shall be clearly marked as “CONFIDENTIAL” and all such
materials and information initially disclosed orally shall be reduced to writing and marked as “CONFIDENTIAL” within
10 days following the date of initial oral disclosure; (ii) all copies of the information and materials described in (i) above;
and (iii) the existence and each of the terms and conditions of this Agreement; provided further that Confidential Information
shall not include information and materials to the extent a Party can demonstrate through its contemporaneous written records that
such information and materials are or have been:

 

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CONFIDENTIAL

 

(a)          known
to the receiving Party, or in the public domain, at the time of its receipt by a Party, or which thereafter becomes part of the
public domain other than by virtue of a breach of this Agreement or the obligations of confidentiality under this Agreement;

 

(b)          received
without an obligation of confidentiality from a Third Party having the right to disclose without restrictions such information;

 

(c)          independently
developed by the receiving Party without use of or reference to Confidential Information disclosed by the other Party; or

 

(d)          released
from the restrictions set forth in this Agreement by the express prior written consent of the disclosing Party.

 

1.14         “Control(s)”
or “Controlled” means the possession by a Party, as of the A&R Effective Date, of rights sufficient
to effect the grant of rights set forth in this Agreement without violating the terms of any agreement with any Third Party.

 

1.15         “Covers”
or “Covered by,” means with reference to a particular Licensed Product or Licensed Service that the manufacture,
use, sale, offering for sale, or importation of such Licensed Product or performance of such Licensed Service would, but for ownership
of, or a license granted under this Agreement to, the relevant IL-13 Patent Right, infringe a Valid Claim under the IL-13 Patent
Rights in the country in which the activity occurs.

 

1.16         “CTA”
means an Investigator-Initiated Clinical Research Support Agreement between Licensee and City of Hope National Medical Center relating
to central memory enriched T cells lentivirally transduced to express the * and a * that is materially consistent with
the form set forth in Exhibit B.

 

1.17         “CTA
Inventions” means any patentable inventions, discoveries, and innovations conceived and reduced to practice by Institution
Personnel solely relating to central memory enriched T cells lentivirally transduced to express the * and a * used in connection
with the Protocol.

 

1.18         “Dispute”
means any controversy, claim or legal proceeding arising out of or relating to this Agreement, or the interpretation, breach, termination,
or invalidity thereof.

 

1.19         “Field”
means the treatment and diagnosis of all human diseases.

 

1.20         “First
Commercial Sale” means, with respect to a particular Licensed Product or Licensed Service in a given country, the
first arm’s-length commercial sale of such Licensed Product or the first performance of such Licensed Service following Marketing
Approval in such country by or under authority of Licensee or any Sublicensee to a Third Party who is not a Sublicensee.

 

1.21         “GAAP”
means generally accepted accounting principles, consistently applied, as promulgated from time to time by the Financial Accounting
Standards Board.

 

 

*Confidential material redacted and filed separately
with the Commission.

 

    	 	4	 

     

    

 

CONFIDENTIAL

 

1.22         “IL-13
Patent Rights” means: (i) Patent Cooperation Treaty (PCT) application no. PCT/US*; (ii) US patent application no. *;
(iii) patents, patent applications, continuation and divisional applications and foreign equivalents that claim the same invention(s)
and priority date as the foregoing; (iv) continuation-in-part applications that repeat a substantial portion of any of the foregoing
applications; (v) Letters Patent or the equivalent issued on any of the foregoing applications throughout the world; (vi) amendments,
extensions, renewals, reissues, and re-examinations of any of the foregoing; and (vii) subject to Section 8.2.4, the CTA Inventions.
Notwithstanding the foregoing, “IL-13 Patent Rights” shall only include any continuation-in-part application
to the extent that claims in such continuation-in-part application are supported in the specification of the parent application,
unless otherwise mutually agreed to in writing by the parties to this Agreement.

 

1.23         “Institution
Personnel” has the meaning set forth in Section 1 of the CTA.

 

1.24         “License
Year” means each calendar year during the term of this Agreement; except that the first License Year shall commence
on the Original Effective Date and end on December 31 of the calendar year in which the Original Effective Date occurs.

 

1.25         “Licensed
Product” means a product (including kits, component sets or components thereof, regardless of concentration or formulation)
that: (i) is Covered by a Valid Claim under the IL-13 Patent Rights, (ii) is manufactured by a process or used in a method Covered
by a Valid Claim under the IL-13 Patent Rights, or (iii) contains, as an active ingredient, any substance the manufacture, use,
offer for sale or sale of which is Covered by a Valid Claim under the IL-13 Patent Rights. By way of clarification, “Licensed
Product” shall include a product manufactured in a country in which such manufacture is Covered by a Valid Claim under the
IL-13 Patent Rights and thereafter exported to and sold in a country in which no Valid Claim under the IL-13 Patent Rights exists.

 

1.26         “Licensed
Service” means any service the performance of which would, but for the license granted herein, infringe a Valid Claim
under the IL-13 Patent Rights.

 

1.27         “Licensee
Confidential Information” means Confidential Information disclosed or provided by, or on behalf of, Licensee to COH
or its designees.

 

1.28         “Marketing
Approval” means all approvals, licenses, registrations or authorizations of any federal, state or local regulatory
agency, department, bureau or other governmental entity, necessary for the manufacturing, use, storage, import, transport, marketing
and sale of Licensed Products or performance of Licensed Services in a country or regulatory jurisdiction.

 

1.29         “Net
Proceeds” means the net proceeds actually received by Licensee from all sales of shares of capital stock after deduction
of all transaction expenses, finder’s fees, advisory fees, legal fees, sales commissions or similar amounts paid to brokers
or dealers and other costs and expenses incurred by Licensee or its subsidiaries in connection therewith. In the event such net
proceeds are not paid to Licensee in cash, the value of such net proceeds will be the fair market value of the assets constituting
such net proceeds.

 

    	 	5	 

     

    

 

CONFIDENTIAL

 

1.30         “Net
Sales” means the total gross amount invoiced by Licensee, its Affiliates and its Sublicensees (regardless of whether
and when such invoices are actually paid) on the sale of Licensed Products and Licensed Services to Third Parties (including, without
limitation, the provision of any product by Licensee, its Affiliates or any of its Sublicensee that incorporates a Licensed Product
or Licensed Service but for clarity excluding documented sponsored research and/or development activities, valued at the actual
direct cost of such activities on a fully burdened basis (including reasonable margin for overhead)), less the following items,
as determined from the books and records of Licensee, its Affiliates or its Sublicensees:

 

(a)          insurance,
handling and transportation charges actually invoiced;

 

(b)          amounts
repaid, credited or allowed for rejection, return or recall;

 

(c)          sales
or other excise taxes or other governmental charges levied on or measured by the invoiced amount (including, without limitation,
value added taxes);

 

(d)          brokerage,
customs and import duties or charges; and

 

(e)          normal
and customary trade and quantity discounts (including chargebacks and allowances) and rebates which relate to the Licensed Products
or Licensed Services.

 

Sales of Licensed Products between or among
Licensee, its Affiliates or its Sublicensees shall be excluded from the computation of Net Sales, except in those instances in
which the purchaser is also the end-user of the Licensed Product sold. Further, transfers of reasonable quantities of Licensed
Product by Licensee, any of its Affiliates or of its Sublicensee to a Third Party that is not a Sublicensee for use in the development
of such Licensed Product (and not for resale) and transfers of industry standard quantities of Licensed Product for promotional
purposes shall not be deemed a sale of such Licensed Product that gives rise to Net Sales for purposes of this Section 1.30.

 

1.31         “Person”
means any person or entity, including any individual, trustee, corporation, partnership, trust, unincorporated organization, limited
liability company, business association, firm, joint venture or governmental agency or authority.

 

1.32         “Phase
1 Clinical Trial” means, as to a specific Licensed Product or Licensed Service, a study as described in 21 C.F.R.
§312.21(a) or a comparable clinical study in a country other than the United States.

 

1.33         “Phase
2 Clinical Trial” means, as to a specific Licensed Product or Licensed Service, a study in humans designed with the
principal purpose of determining initial efficacy and dosing of such Licensed Product in patients for the indication(s) being studied
as described in 21 C.F.R. §312.21(b); or a similar clinical study in a country other than the United States.

 

1.34         “Phase
3 Clinical Trial” means, as to a specific Licensed Product or Licensed Service, a lawful study in humans of the efficacy
and safety of such Licensed Product or Licensed Service, which is prospectively designed to demonstrate statistically whether such
Licensed Product is effective and safe for use in a particular indication in a manner sufficient to file an application to obtain
Marketing Approval to market and sell that Licensed Product or Licensed Service in the United States or another country for the
indication being investigated by the study, as described in 21 C.F.R. § 312.21(c); or similar clinical study in a country
other than the United States.

 

    	 	6	 

     

    

 

CONFIDENTIAL

 

1.35         “Protocol”
has the meaning set forth in Section 1 of the CTA.

 

1.36         “Qualified
Financing” means the sale of capital stock of Licensee, in one or more transactions, that constitute a bona fide
equity financing at such time as the Net Proceeds to Licensee from third party investors that are not Affiliates of Licensee in
such equity financing(s) are less than or equal to the Qualified Financing Protection Ceiling; provided that if capital stock of
Licensee is sold in a single transaction or series of related transactions for different purchase prices and any of such shares
of capital stock are included for purposes of determining the number of shares of Qualifying Stock to be issued to COH pursuant
to Section 4.3, each share of capital stock that is sold for the lowest purchase price shall be deemed to be have sold first (regardless
of the date on which such shares are actually sold) and the next number of shares of capital stock that are sold for the next highest
purchase price shall be deemed to have sold next, et cetera, until the Net Proceeds from all such sales (applying all transaction
expenses to the first shares issued (except to the extent that such expenses are calculated on a per share basis, such as sales
commission, which shall be applied only to the shares included in such calculation) are equal to the Qualified Financing Protection
Ceiling.

 

1.37         “Qualified
Financing Protection Ceiling” means $*. 

 

1.38         “Qualified
Public Offering” means the first public offering of the Common Stock of Licensee to the general public that is effected
pursuant to a registration statement filed with, and declared effective by, the United States Securities and Exchange Commission
under the Act, as amended, but, for purposes of clarity shall not include an offering effected pursuant to a registration statement
on Form S-8 or any successor form.

 

1.39         “Qualifying
Stock” means the sum of: (i) the shares of Class A Common Stock issued and to be issued to COH in accordance with
Section 4.3, (ii) the number of shares of Common Stock (excluding (x) the shares referenced in the foregoing subclause (i) and
(y) shares issued to employees, directors and consultants in their capacity as such) of Licensee outstanding, and (iii) the maximum
number of shares of Common Stock of Licensee issuable (assuming the satisfaction of any conditions to exercisability, convertibility
or exchangeability) upon the exercise, conversion or exchange of all evidences of indebtedness, shares or other securities directly
or indirectly convertible into or exchangeable for Common Stock of the Licensee, including all rights, options or warrants to subscribe
for, purchase or otherwise acquire shares of Common Stock of the Licensee but excluding options and rights granted to employees,
directors and consultants in their capacity as such).

 

 

*Confidential material redacted and filed separately
with the Commission.

 

    	 	7	 

     

    

 

CONFIDENTIAL

 

1.40         “Spacer
Patent Rights” means: (i) Patent Cooperation Treaty (PCT) application no. PCT/US*; (ii) US patent application no. *; (iii)
patents, patent applications, continuation and divisional applications and foreign equivalents that claim the same invention(s)
and priority date as the foregoing; (iv) continuation-in-part applications that repeat a substantial portion of any of the foregoing
applications; (v) Letters Patent or the equivalent issued on any of the foregoing applications throughout the world; (vi) amendments,
extensions, renewals, reissues, and re-examinations of any of the foregoing; and (vii) any claim in a patent or patent application
licensed to Licensee by COH pursuant to an applicable license agreement that claims (a) a COH CAR, and (b) the spacer, hinge, or
linker sequence(s) that is used to connect the extracellular ligand-binding domain to transmembrane and intracellular-signaling
domains of such COH CAR covered by a Valid Claim of any of the foregoing (i)-(vii). Notwithstanding the foregoing, “Spacer
Patent Rights” shall only include any continuation-in-part application to the extent that claims in such continuation-in-part
application are supported in the specification of the parent application, unless otherwise mutually agreed to in writing by the
parties to this Agreement.

 

1.41         “Study
Data” means all results, data, analyses, reports, and other documentation relating to central memory enriched T cells
lentivirally transduced to express an *;  and a * resulting from, or generated in the course of or with respect to,
the performance of the Protocol.

 

1.42         “Sublicensee”
means any Affiliate of Licensee or Third Party which enters into an agreement with Licensee involving the grant to such Affiliate
or Third Party of any rights under the license granted to Licensee pursuant to this Agreement.

 

1.43         “Sublicense
Revenues” means all consideration, in whatever form, due from a Sublicensee in return for the grant of a sublicense
of Licensee’s rights hereunder, excluding consideration in the form of: (i) royalties received by Licensee and calculated
wholly as a function of sales of Licensed Products or Licensed Services, (ii) payments or reimbursement for documented sponsored
research and/or development activities, valued at the actual direct cost of such activities on a fully burdened basis (including
reasonable margin for overhead), (iii) payment or reimbursement of reasonable patent expenses actually incurred or paid by Licensee
and not otherwise reimbursed, or payment of patent expenses required to by paid by Licensee hereunder, (iv) payments for the purchase
of equity in Licensee at the fair market value of such equity, and (v) payments recognized as Net Sales under this Agreement for
which a royalty is payable to COH. By way of clarification, the principal amount of any loan or other extension of credit provided
to Licensee or an Affiliate of Licensee in connection with the grant of a sublicense by Licensee that is other than an arm’s-length
credit relationship shall be deemed to constitute “Sublicense Revenues.”

 

1.44         “Territory”
means the entire world.

 

1.45         “Third
Party” means a Person that is neither a Party to this Agreement nor an Affiliate of a Party.

 

1.46         “Valid
Claim” means a claim of a pending patent application or an issued and unexpired patent included in, as applicable,
the IL-13 Patent Rights or the Spacer Patent Rights, in a particular jurisdiction, which claim has not, in such jurisdiction been
finally rejected or been declared invalid or cancelled by the patent office or a court of competent jurisdiction in a decision
that is no longer subject to appeal as a matter of right.

 

 

*Confidential material redacted and filed separately
with the Commission.

 

    	 	8	 

     

    

 

CONFIDENTIAL

 

ARTICLE
2: DEVELOPMENT AND COMMERCIALIZATION EFFORTS

 

2.1           Development
and Commercialization Responsibilities. Licensee shall have the sole right and responsibility for, and control over, all
development, manufacturing and commercialization activities (including all regulatory activities) with respect to Licensed Products
and Licensed Services in the Field.

 

2.2           Licensee
Diligence. Licensee shall use Commercially Reasonable Efforts to develop and commercialize Licensed Products and Licensed
Services in the Field, directly or through one or more Sublicensees. Without limiting the foregoing, if Licensee, directly or through
one or Sublicensees, fails to accomplish any one of the “Diligence Milestones” set forth in this Section 2.2
by the date specified (each a “Deadline Date”) corresponding to such Diligence Milestone, COH shall have the
right, on notice to Licensee, to terminate this Agreement.

 

	“Deadline Date”	 	“Diligence Milestone”
	 	 	 
	1.  * (*) * from the Original Effective Date	 	Licensee to receive not less than $* through any combination of:  (i) Net Proceeds from the sale of any equity securities (or securities convertible into or exercisable for equity securities) and (ii) unrestricted grants or gifts.  
	 	 	 
	2.  * (*) * from the Original Effective Date	 	Licensee to * (with COH listed as principal institution for the clinical
    trial).  Licensee may extend this Deadline Date for up to * (*) additional * (*) month periods upon payment of $*
    to COH, for each * month  (*) period.
	 	 	 
	3.  * (*) * from the Original Effective Date	 	Licensee to * (with COH listed as principal institution for the clinical trial).  Licensee may extend this Deadline Date for up to * (*) additional * (*) month periods upon payment of $* to COH for each * month (*) period.  If, however, this Diligence Milestone is not achieved after these * (*) extensions through no fault of Licensee, this Diligence Milestone will be additionally extended for as long as the Research Agreement is in effect.

 

 

*Confidential material redacted and filed separately
with the Commission.

 

    	 	9	 

     

    

 

CONFIDENTIAL

 

2.3           Governance.
COH and Licensee shall each designate one individual to serve as the main point of contact for communications related to development
and commercialization of Licensed Products and Licensed Services under this Agreement (each a “Designated Representative”).
The initial Designated Representative of COH shall be George Megaw and the initial Designated Representative of Licensee shall
be Michael S. Weiss. Each Party may replace its Designated Representative at any time upon prior notice to the other Party. Licensee
shall keep COH reasonably informed as to progress in the development and commercialization of Licensed Products and Licensed Services.
Without limiting the foregoing, on or before January 15 and July 15 of each year during the term of this Agreement, Licensee shall
provide to COH a written report setting forth, in reasonable detail, its activities and achievements with respect to the development
and commercialization of Licensed Products and Licensed Services during the preceding six months (the “Semi-Annual Report”).
Each Semi-Annual Report shall also include the COH reference number, OTL 16-542. The Designated Representatives shall meet in person
twice each calendar year to present and discuss the current Semi-Annual Report at such location and date as mutually agreed. Each
Party shall be responsible for all expenses incurred by its Designated Representative in the participation in such annual meetings.
A copy of each Semi-Annual Report shall be provided, in addition to the persons set forth in Section 14.7, to: The Office of Technology
Licensing, email: licensing@coh.org.

 

ARTICLE
3: LICENSE GRANTS

 

3.1           Grant
of Rights.

 

3.1.1           Exclusive
Patent License. COH hereby grants to Licensee an exclusive royalty-bearing right and license under the IL-13 Patent Rights
to make, have made, use, offer for sale, sell and import Licensed Products and to perform Licensed Services, in the Field, in the
Territory; provided, however, the foregoing license does not include any right or license under any
patent claim of the IL-13 Patent Rights that includes a limitation directed toward the COH Spacer Technology. The Parties acknowledge
and agree that Licensee is granted rights to practice such COH Spacer Technology pursuant to the A&R Spacer License.

 

3.1.2           Exclusive
Study Data License. Subject to Section 8.2.4, COH hereby grants to Licensee an exclusive right and license under the Study
Data to make, have made, use, offer for sale, sell and import Licensed Products and to perform Licensed Services, in the Field,
in the Territory.

 

3.1.3           The
foregoing grant of rights shall be subject to: (i) the retained rights of the U.S. Government in the IL-13 Patent Rights pursuant
to 35 U.S.C. §§ 200-212 and applicable U.S. government regulations, (ii) the royalty-free right of COH and its Affiliates
to practice the IL-13 Patent Rights and the Study Data for educational and research uses, (iii) the right of COH and its Affiliates
to publicly disclose research results including, to the extent applicable, as specified in the Research Agreement, and (iv) the
right of COH and its Affiliates to allow other non-profit institutions to use the IL-13 Patent Rights and the Study Data for the
same purposes as (ii) and (iii).

 

3.2           No
Implied Licenses. Licensee acknowledges that the licenses granted in this Agreement are limited to the scope expressly
granted and that, subject to the terms and conditions of this Agreement, all other rights under all IL-13 Patent Rights, the Study
Data, and other intellectual property rights Controlled by COH are expressly reserved to COH.

 

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CONFIDENTIAL

 

3.3           Sublicensing.
Licensee shall have the right to sublicense its rights hereunder without the consent of COH, effective on notice to COH. The terms
and conditions of each sublicense of Licensee’s rights hereunder shall be consistent with this Agreement. A true and complete
copy of each sublicense of Licensee’s rights hereunder, as well as any amendment thereto, shall be delivered to COH promptly
following the effective date of each such sublicense or amendment.

 

3.4           Effect
of Termination on Sublicenses.

 

(a)          In
the event that this Agreement terminates at any time for any reason, each sublicense validly granted hereunder which is in good
standing as of the effective date of such termination shall continue in effect as a direct license between COH (as licensor) and
Sublicensee (as licensee), provided that: (i) such sublicense, as determined by COH in its reasonable and good faith discretion,
contains or imposes on COH no material obligation or liability additional to those set forth in this Agreement, (ii) the Sublicensee
delivers to COH, within thirty (30) days of the effective date of the termination of this Agreement, written acknowledgement that
all payment and other obligations previously payable to Licensee under such sublicense shall thereafter be payable and due, and
be paid directly to COH, and (iii) such Sublicensee (including its employees and contractors) is not at such time debarred or excluded
or otherwise ineligible for participation in federally funded programs. All other sublicenses in existence as of the effective
date of the termination of this Agreement which fail to satisfy the foregoing conditions shall, upon such termination, terminate.

 

(b)          Further
and in addition to the requirements of Section 3.4(a), above, the conversion of a sublicense into a direct license between COH
(as licensor) and Sublicensee (as licensee) upon termination of this Agreement shall require that either [A] or [B] (but not both),
below, be satisfied:

 

[A]        On the effective date of the
termination of this Agreement:

 

(i)          the
Sublicensee is not a party to a proceeding in bankruptcy or insolvency filed by or against such Sublicensee, has not made a general
assignment for the benefit of its creditors, and is not in litigation with COH or any Affiliate of COH, and

 

(ii)         (1)
the effective royalty rate payable on Sublicensee’s Net Sales of Licensed Products and Licensed Services, (2) the aggregate
of other non- sale/royalty-based consideration due from Sublicensee, and (3) the other material terms and conditions of the sublicense
are materially no less favorable to COH than the corresponding terms (excluding the stock grant due pursuant to Section 4.3, below)
of this Agreement, or

 

[B]         the terms and
conditions of the sublicense had been approved by COH prior to its having been entered into by Licensee and the Sublicensee, such
approval having been considered by COH expeditiously and not conditioned on the payment by Licensee of any additional consideration.

 

    	 	11	 

     

    

 

CONFIDENTIAL

 

3.5           Documentation
of Licensed Services. Licensee and its Sublicensees shall provide Licensed Services only pursuant to one or more written
agreements which set forth, in reasonable detail, all consideration due to Licensee for the provision of such services. Licensee
shall provide a true and complete copy of each such agreement to COH promptly following the effective date of such agreement.

 

ARTICLE
4: PAYMENTS

 

4.1           Up-Front
Payment. The Parties acknowledge and agree that the non-refundable license fee of $* payable by Licensee within
thirty (30) days after the Original Effective Date pursuant to the Original Agreement has been paid by Licensee as of the A&R
Effective Date.

 

4.2           License
Maintenance Fee. On or before the tenth Business Day after the end of each License Year (excluding the first License Year
ending December 31, 2015), Licensee shall pay to COH a non-refundable license maintenance fee of $*. The license maintenance fee
paid in a given License Year shall be applied as credit against royalties otherwise due to COH pursuant to Section 4.8, below,
during the License Year in which payment was made but may not be carried over and applied as credit against royalties due in subsequent
years.

 

4.3           Stock
Grant.

 

(a)          Concurrently
with the execution of the Original Agreement, Licensee issued to COH stock certificates evidencing 333,333 validly issued, fully-paid,
non-assessable shares of Class A Common Stock. At the closing of each Qualified Financing that occurs prior to the achievement
of the Qualified Financing Protection Ceiling, Licensee will issue to COH and such reasonable number of designees as COH may specify
(provided that each such designee has: (i) demonstrated to the reasonable satisfaction of Licensee that it is an “accredited
investor” as such term is defined in Regulation D promulgated under the Securities Act of 1933 (the “Act”),
(ii) represented to Licensee that it is acquiring the shares for investment purposes only, and (iii) acknowledged that the shares
to be received are restricted securities under the Act (COH and its designees collectively, the “COH Stockholders”),
stock certificates evidencing a number of shares of validly issued, fully-paid, non-assessable shares of Class A Common Stock that
is determined such that upon the completion of such issuance, COH and its designees will hold 10% of the total number of shares
of Qualifying Stock, calculated as of immediately after the closing of such Qualified Financing (the “Measurement Date”).
Promptly after the applicable Measurement Date, Licensee will deliver to the COH Stockholders (i) certificates representing the
shares of Class A Common Stock to be issued in accordance with the foregoing, and (ii) a certificate, executed on behalf of Licensee
by an executive officer of Licensee, showing Licensee’s calculation of the number of shares of Qualifying Stock as of the
Measurement Date, the sales price of each share of capital stock issued in the Qualified Financings, and the gross proceeds and
Net Proceeds of the Qualified Financings and Licensee’s calculation of the shares of Class A Common Stock to be issued to
the COH Stockholders. Such shares of Class A Common Stock will be issued in consideration for the benefits provided to Licensee
under the Agreement and no additional consideration shall be payable for such shares of Class A Common Stock.

 

 

*Confidential material redacted and filed separately
with the Commission.

 

    	 	12	 

     

    

 

CONFIDENTIAL

 

(c)          COH
and the other COH Stockholders acknowledge and agree that the COH Shares will be restricted securities and will not be registered
with the Securities and Exchange Commission or qualified with any state securities authority and that, accordingly, the COH Shares
may not be distributed, sold or otherwise transferred except pursuant to an effective registration statement under the Act or pursuant
to an available exemption from the registration requirements of the Act.

 

4.4           First
Public Offering Fee. At the closing of the first Qualified Public Offering of stock of Licensee, Licensee shall pay COH
a one-time non-refundable fee of $*.

 

4.5           Sale
of Business. Upon any Change in Control of Licensee, Licensee shall pay COH a non-refundable fee of $*.

 

4.6           [Reserved]

 

4.7           Milestone
Payments. Within thirty (30) days after the occurrence of each “Milestone Event” set forth below, Licensee
shall pay COH or its designee the amount indicated below:

 

	Milestone Event	 	Amount Due	 
	#1.  Upon *.	 	$	*	 
	#2.  Upon *.	 	$	*	 
	#3.  Upon the *.	 	$	*	 
	#4.  Upon the *.	 	$	*	 
	#5.  Upon *.	 	$	*	 
	#6.  Upon *.	 	$	*	 
	#7.  Upon *.	 	$	*	 
	#8.  Upon *.	 	$	*	 

 

In the event that any *, then Licensee shall also pay the amount due for occurrence of Milestone
Event #5 upon receiving such * (e.g., if *, Licensor shall pay COH $*).  The Parties agree that in the event that a *, then Licensee shall simultaneously pay the amounts due for occurrence of Milestone
Event #1 and Milestone Event #2 (e.g., if a *, Licensor
shall pay COH $*). For clarity, each payment above shall be made only once, regardless of the number of Licensed Products or Licensed
Services achieving each Development Milestone Event.

 

 

*Confidential material redacted and filed separately
with the Commission.

 

    	 	13	 

     

    

 

CONFIDENTIAL

 

4.8           Royalties.

 

(a)          Subject
to Subsection (c) and Section 4.9 below, Licensee shall pay to COH or its designee royalties in an amount equal to (i) * percent
of Net Sales of Licensed Products up to and including $*; (ii) * percent of Net Sales of Licensed Products greater than $* up to
and including $*; and (iii) * percent of Net Sales of Licensed Products that exceed $*. Royalties shall be paid on a Licensed Product-by-Licensed
Product and country-by-country basis until the expiration in each country of the last to expire of the Valid Claims under the IL-13
Patent Rights in such country Covering Licensed Product.

 

(b)          Subject
to Subsection (c) and Section 4.9 below, Licensee shall pay to COH or its designee royalties in an amount equal to (i) * percent
of Net Sales of Licensed Services up to and including $*; (ii) * percent of Net Sales of Licensed Services greater than $* up to
and including $*; and (iii) * percent of Net Sales of Licensed Services that exceed $*. Royalties shall be paid on a Licensed Service-by-Licensed
Service and country-by-country basis until the expiration in each country of the last to expire of the Valid Claims under the IL-13
Patent Rights in such country Covering Licensed Service.

 

(c) Beginning in the
calendar year of Marketing Approval in any jurisdiction of the first Licensed Product or Licensed Service by Licensee or Sublicensees
and if the total earned royalties paid by Licensee under Sections 4.8(a) and (b) in any such year cumulatively amounts to less
than $* for that calendar year (“Minimum Annual Royalty”), Licensee shall pay to COH on or before February 28
following the last quarter of such year the difference between the $* minimum royalty noted above and the total earned royalty
paid by Licensee for such year under Sections 4.8(a) and (b), provided, however, that for the first year of commercial
sales of the first Licensed Product or Licensed Services, the amount of minimum annual royalty payable shall be pro-rated for the
number of months remaining in that calendar year.

 

4.9           Royalty
Offsets.

 

4.9.1           Third
Parties. If, in Licensee’s reasonable business judgment it is necessary to pay to a Third Party other than a Sublicensee
consideration (whether in the form of a royalty or otherwise) for the right to make, have made, use, sell, offer for sale or import
a Licensed Product or Licensed Service in a given jurisdiction, and if the aggregate royalty rates of any and all royalties payable
to such Third Party licensors when combined with the royalty rate payable to COH exceeds * percent in the case of Net
Sales of Licensed Products or Licensed Services, then Licensee shall have the right with respect to any period for which royalties
are due (i.e., a calendar quarter or calendar year) to set off * percent of the aggregate royalties otherwise payable with respect
to such period and such jurisdiction to such Third Party licensors against royalties that would otherwise be due to COH hereunder
with respect to such period and jurisdiction; provided, however, that each Third Party licensor agrees to be stacked
proportionally; and provided further, however, that under no circumstances shall the royalty offsets permitted in this Section
4.9.1 result in the reduction of the effective adjusted royalty rate and the royalty amount otherwise due to COH in any period
for which payment is due and in any jurisdiction pursuant to Section 4.8, above, by more than * percent (e.g., minimum effective
adjusted royalty rate for Licensed Product or Licensed Services sales up to $* shall be * percent).

 

 

*Confidential material redacted and filed separately
with the Commission.

 

    	 	14	 

     

    

 

CONFIDENTIAL

 

4.9.2           A&R
Spacer License. In the event that royalties are due to COH by Licensee pursuant to Section 4.7(b) of the A&R Spacer License,
then Licensee may set off such royalties payable to COH against the royalties payable to COH by Licensee pursuant to Section 4.8
of this Agreement.

 

4.10         Sublicense
Revenues. Licensee shall pay to COH a percentage of all Sublicense Revenues within thirty
(30) days after payment is received from the relevant Sublicensee, determined as follows:

 

(a)          *
percent of Sublicense Revenues if the Sublicense is granted prior to the *,

 

(b)          *
percent of all Sublicense Revenues if the Sublicense is granted prior to the *,

 

(c)          *
percent of all Sublicense Revenues if the Sublicense is granted prior to the *, and

 

(d)          *
percent of all Sublicense Revenues if the Sublicense is granted after *.

 

If Sublicense Revenues are
not in cash or cash equivalents, the percentage share payable to COH pursuant to this Section 4.10 shall be due, in COH’s
sole discretion, either in kind or in its cash equivalent.

 

4.11         Timing
of Royalty Payments. Royalty payments due under Section 4.8, above, shall be paid annually within sixty (60) days following
the end of each License Year until the first License Year in which aggregate Net Sales reach $*.  Thereafter, all royalty
payments due under Section 4.8 shall be paid in quarterly installments, within sixty (60) days following the end of each calendar
quarter.

 

4.12         No
Deductions from Payments. Licensee is solely responsible for payment of any fee, royalty or other payment due to any Third
Party not a Sublicensee in connection with the research, development, manufacture, distribution, use, sale, import or export of
a Licensed Product or Licensed Service and, except as set forth in Section 4.9.1, above, Licensee shall not have the right to set
off any amounts paid to such a Third Party, including fee, royalty or other payment, against any amount payable to COH hereunder.

 

4.13         Single
Royalty. Only a single royalty payment shall be due and payable on Net Sales of a Licensed Product or performance of a
Licensed Service, regardless if such Licensed Product or Licensed Service is Covered by more than one Valid Claim under the IL-13
Patent Rights.

 

 

*Confidential material redacted
and filed separately with the Commission.

 

    	 	15	 

     

    

 

 

CONFIDENTIAL

 

ARTICLE
5: REPORTS, AUDITS AND FINANCIAL TERMS

 

5.1           Royalty
Reports. Within sixty (60) days after the end of each calendar quarter in which a royalty payment under Article 4 is required
to be made, Licensee shall send to COH a report of Net Sales of the Licensed Products and Licensed Services for which a royalty
is due, which report sets forth for such calendar quarter the following information, on a Licensed Product-by-Licensed Product,
Licensed Service-by-Licensed Service and country-by-country basis: (i) total Net Sales, (ii) total gross sales of Licensed Products
and Licensed Services, (iii) the quantity of each Licensed Products sold and Licensed Services performed, (iv) the exchange rate
used to convert Net Sales from the currency in which they are earned to United States dollars; and (v) the total royalty payments
due. All royalty reports shall also include the COH reference number, OTL 16-542. A copy of each royalty report shall be provided,
in addition to the persons set forth in Section 14.7, to: The Office of Technology Licensing, email: otl-royalties@coh.org.

 

5.2           Additional
Financial Terms.

 

5.2.1           Currency.
All payments to be made under this Agreement shall be made in United States dollars, unless expressly specified to the contrary
herein. Net Sales outside of the United States shall be first determined in the currency in which they are earned and shall then
be converted into an amount in United States dollars. All currency conversions shall use the conversion rate reported by Reuters,
Ltd. on the last Business Day of the calendar quarter for which such payment is being determined.

 

5.2.2           Payment
Method. Amounts due under this Agreement shall be paid in immediately available funds, by means of wire transfer to an
account identified by COH.

 

5.2.3           Withholding
of Taxes. Licensee may withhold from payments due to COH amounts for payment of any withholding tax that is required by
law to be paid to any taxing authority with respect to such payments. Licensee shall provide to COH all relevant documents and
correspondence, and shall also provide to COH any other cooperation or assistance on a reasonable basis as may be necessary to
enable COH to claim exemption from such withholding taxes and to receive a full refund of such withholding tax or claim a foreign
tax credit. Licensee shall give COH proper evidence from time to time as to the payment of such tax. The Parties shall cooperate
with each other in seeking deductions under federal and state tax laws and any double taxation or other similar treaty or agreement
from time to time in force.

 

5.2.4           Late
Payments. Any amounts not paid on or before the date due under this Agreement are subject to interest from the date due
through and including the date upon which payment is received. Interest is calculated, over the period between the date due and
the date paid, at a rate equal to * percentage point (*%) over the “bank prime loan” rate, as such rate
is published in the U.S. Federal Reserve Bulletin H.15 or successor thereto on the last Business Day of the applicable calendar
quarter prior to the date on which such payment is due.

 

 

*Confidential material
redacted and filed separately with the Commission.

 

    	 	16	 

     

    

 

CONFIDENTIAL

 

5.2.5           Blocked
Currency. If, at any time, legal restrictions prevent the prompt remittance of part or all royalties with respect to any
country where a Licensed Product is sold or Licensed Service provided, payment shall be made through such lawful means or methods
as Licensee may determine. When in any country, the law or regulations prohibit both the transmittal and deposit of royalties or
other payments, Licensee shall continue to report all such amounts, but may suspend payment for as long as such prohibition is
in effect. As soon as such prohibition ceases to be in effect, all amounts that would have been obligated to be transmitted or
deposited but for the prohibition, together with accrued interested thereon, shall promptly be transmitted to COH.

 

5.3           Accounts
and Audit.

 

5.3.1           Records.
Licensee shall keep, and shall require that each Sublicensee keep, full, true and accurate books of account containing the particulars
of its Net Sales and the calculation of royalties. Licensee and its Sublicensees shall each keep such books of account and the
supporting data and other records at its principal place of business. Such books and records must be maintained available for examination
in accordance with this Section 5.3.1 for five calendar years after the end of the calendar year to which they pertain, and otherwise
as reasonably required to comply with GAAP.

 

5.3.2           Appointment
of Auditor. COH may appoint an internationally- recognized independent accounting firm reasonably acceptable to Licensee
to inspect the relevant books of account of Licensee and its Sublicensees to verify any reports or statements provided, or amounts
paid or invoiced (as appropriate), by Licensee or its Sublicensees.

 

5.3.3           Procedures
for Audit. COH may exercise its right to have Licensee’s and its Sublicensees’ relevant records examined only
during the five year period during which Licensee is required to maintain records, no more than once in any consecutive four calendar
quarters. Licensee and its Sublicensees are required to make records available for inspection only during regular business hours,
only at such place or places where such records are customarily kept, and only upon receipt of at least 15 days advance notice
from COH.

 

5.3.4           Audit
Report. The independent accountant will be instructed to provide to COH an audit report containing only its conclusions
and methodology regarding the audit, and specifying whether the amounts paid were correct and, if incorrect, the amount of any
underpayment or overpayment.

 

5.3.5           Underpayment
and Overpayment. After review of the auditor’s report: (i) if there is an uncontested underpayment by Licensee for
all of the periods covered by such auditor’s report, then Licensee shall pay to COH the full amount of that uncontested underpayment,
and (ii) if there is an uncontested overpayment for such periods, then COH shall provide to Licensee a credit against future payments
(such credit equal to the full amount of that overpayment), or, if Licensee is not obligated to make any future payments, then
COH shall pay to Licensee the full amount of that overpayment. Contested amounts are subject to dispute resolution under Article
12. If the total amount of any such underpayment (as agreed to by Licensee or as determined under Article 12) exceeds * percent
of the amount previously paid by Licensee for the period subject to audit, then Licensee shall pay the reasonable costs for the
audit. Otherwise, all costs of the audit shall be paid by COH.

 

 

*Confidential material
redacted and filed separately with the Commission.

 

    	 	17	 

     

    

 

CONFIDENTIAL

 

ARTICLE
6: LICENSEE COVENANTS

 

6.1           Licensee
covenants and agrees that:

 

(a)          During
the period commencing on the Original Effective Date and ending on the third (3rd) anniversary of the Original Effective
Date, both Dr. Lindsay A. Rosenwald and Michael S. Weiss will hold senior management positions of Licensee; provided, that, in
the event of a Change of Control of Licensee, subsequent to such Change of Control, in the event that either Dr. Lindsay A. Rosenwald
or Michael S. Weiss no longer holds a senior management position of Licensee both individuals must remain materially involved with
the oversight and management of the development of Licensed Products during such period; provided further that in the event of
the death of either of Dr. Rosenwald or Mr. Weiss, Licensee will be excused from observing this Section 6.1(a) with regard to the
decedent;

 

(b)          the
Charter provides, and any amendment thereto will provide, the holders of Class A Shares with the right to nominate one individual
to the board of directors of Licensee for a period of ten years after the formation of Licensee;

 

(c)          in
conducting activities contemplated under this Agreement, it shall comply in all material respects with all applicable laws and
regulations including, without limitation, those related to the manufacture, use, labeling importation and marketing of Licensed
Products and Licensed Services;

 

(d)          Licensee
had obtained and after the date hereof will obtain all authorizations necessary for the issuance of the COH Shares and the Common
Stock issuable to COH upon conversion of the COH Shares issuable pursuant to this Agreement and/or the Charter prior to the issuance
of such COH Shares and in any event prior to the issuance of any Qualifying Stock or the consummation of a Change of Control and
covenants that all such shares issued on or prior to the date hereof are, and those issued after the date hereof will be, validly
issued, fully paid and non-assignable and free of restrictions on transfer, other than restrictions on transfer under state and
federal securities laws; and

 

(e)          without
limiting the foregoing and notwithstanding any other provision in this Agreement, Licensee acknowledges and agrees that it is an
exclusive Licensee under this Agreement and agrees (i) to be subject to all laws and other obligations applicable to the CIRM Grant
as they apply to an exclusive Licensee, including diligence, reporting, access and pricing requirements, and (ii) to assist COH
as necessary to ensure COH remains in compliance with any laws and other obligations applicable to the CIRM Grant.

 

    	 	18	 

     

    

 

CONFIDENTIAL

 

ARTICLE
7: INTELLECTUAL PROPERTY; PATENT PROSECUTION, MAINTENANCE AND ENFORCEMENT.

 

7.1           Patent
Prosecution, Maintenance and Enforcement.

 

(a)          COH
shall be responsible for the preparation, filing, prosecution, and maintenance of all IL-13 Patent Rights, using counsel of its
choice. COH will timely provide Licensee with copies of all relevant documentation relating to such prosecution and Licensee shall
keep such information confidential. In addition, COH shall instruct the patent counsel prosecuting IL-13 Patent Rights to (i) copy
Licensee on patent prosecution documents that are received from or filed with the United States Patent and Trademark Office and
foreign equivalent, as applicable; (ii) if requested by Licensee, provide Licensee with copies of draft submissions to the USPTO
prior to filing; and (iii) give reasonable consideration to the comments and requests of Licensee or its patent counsel, provided
that (a) COH reserves the sole right to make all final decisions with respect to the preparation, filing, prosecution and maintenance
of such patent applications and patents; and (b) the patent counsel remains counsel to COH (and shall not jointly represent Licensee
unless requested by Licensee and approved by COH, and an appropriate engagement letter and conflict waiver are in effect). All
patents and patent applications in IL-13 Patent Rights, to the extent assignable in whole or in part to COH, shall be assigned
to COH.

 

(b)          COH
will not unreasonably refuse to amend any patent application in IL-13 Patent Rights to include claims reasonably requested by Licensee
to protect the products contemplated to be sold by Licensee under this Agreement. If Licensee informs COH of other countries or
jurisdictions in which it wishes to obtain patent protection with respect to the IL-13 Patent Rights, COH shall prepare, file,
prosecute and maintain patent applications in such counties and any patents resulting therefrom (and, for the avoidance of doubt,
such patent applications and patents shall be deemed included in the IL-13 Patent Rights). On a country by country and patent by
patent basis, Licensee may elect to surrender any patent or patent application in IL-13 Patent Rights in any country upon sixty
(60) days advance written notice to COH. Such notice shall relieve Licensee from the obligation to pay for future patent costs
but shall not relieve Licensee from responsibility to pay patent costs incurred prior to the expiration of the sixty (60) day notice
period. Such U.S. or foreign patent application or patent shall thereupon cease to be a IL-13 Patent Right hereunder, Licensee
shall have no further rights therein and COH shall be free to license its rights to that particular U.S. or foreign patent application
or patent to any other party on any terms.

 

(c)          Each
Party shall promptly provide written notice to the other in the event it becomes aware of any actual or probable infringement of
any of the IL-13 Patent Rights in or relevant to the Field or of any Third Party claim regarding the enforceability or validity
of any IL-13 Patent Rights (“Infringement Notice”). Licensee shall, in cooperation with COH, use reasonable
efforts to terminate infringement without litigation.

 

(d)          If
infringing activity has not been abated within ninety (90) days following the date the Infringement Notice takes effect, then Licensee
may, following consultation with COH, in its sole discretion and at its sole expense, take action against any alleged infringer
or in defense of such any claim, provided, that Licensee has exclusive rights under this Agreement. Any recovery
obtained by Licensee as the result of legal proceedings initiated and paid for by Licensee pursuant to this subsection (d), after
deduction of Licensee’s reasonable out-of-pocket expenses incurred in securing such recovery, shall be deemed to be Net Sales
of Licensed Products and/or Licensed Services in the calendar quarter in which such recovery was received and royalties shall be
due and payable thereon accordingly.

 

    	 	19	 

     

    

 

CONFIDENTIAL

 

(e)          If
COH is involuntarily joined in a suit initiated by Licensee, then the Licensee will pay any costs incurred by COH arising out of
such suit, including but not limited to, reasonable legal fees of counsel that COH selects and retains to represent it in the suit.

 

(f)          In
the event that Licensee declines either to cause such infringement to cease (e.g., by settlement or injunction) or to initiate
and thereafter diligently maintain legal proceedings against the infringer other than as part of a mutually agreed upon bona fide
strategy, developed with the guidance of outside patent counsel, to preserve the IL-13 Patent Rights, COH may, in its sole discretion
and at its sole expense, take action against such alleged infringer or in defense of any such Third Party claim. Any recovery obtained
by COH as the result of any such legal proceedings shall be for the benefit of COH only.

 

7.2           Trademarks.
Licensee shall be responsible for the selection, registration, maintenance, and defense of all trademarks for use in connection
with the sale or marketing of Licensed Products and Licensed Services in the Field in the Territory (the “Marks”),
as well as all expenses associated therewith. All uses of the Marks by Licensee or a Sublicensee shall comply in all material respects
with all applicable laws and regulations (including those laws and regulations particularly applying to the proper use and designation
of trademarks in the applicable countries). Licensee shall not, without COH’s prior written consent, use any trademarks or
house marks of COH (including the COH corporate name), or marks confusingly similar thereto, in connection with Licensee commercialization
of Licensed Products or Licensed Services under this Agreement in any promotional materials or applications or in any manner implying
an endorsement by COH of Licensee or the Licensed Products or Licensed Services. Licensee shall own all Marks.

 

7.3           Challenge
to the IL-13 Patent Rights by Licensee.

 

(a)          COH
may terminate this Agreement and, notwithstanding Section 3.3, above, all Sublicenses issued hereunder, upon written notice to
Licensee in the event that Licensee or any of its Affiliates or Sublicensees directly or indirectly asserts a Patent Challenge.
“Patent Challenge” means any challenge in a legal or administrative proceeding to the patentability, validity
or enforceability of any of the IL-13 Patent Rights (or any claim thereof), including by: (a) filing or pursuing a declaratory
judgment action in which any of the IL-13 Patent Rights is alleged to be invalid or unenforceable; (b) citing prior art against
any of the IL-13 Patent Rights, filing a request for or pursuing a re-examination of any of the IL-13 Patent Rights (other than
with COH’s written agreement), or becoming a party to or pursuing an interference; or (c) filing or pursuing any re-examination,
opposition, cancellation, nullity or other like proceedings against any of the IL-13 Patent Rights; but excluding any challenge
raised as a defense against a claim, action or proceeding asserted by COH against Licensee, its Affiliates or Sublicensees. In
lieu of exercising its rights to terminate under this Section 7.3(a) COH may elect upon written notice to increase the payments
due under all of Section 4 by * percent (*%), which election will be effective retroactively to the date of the commencement
of the Patent Challenge. Licensee acknowledges and agrees that this Section 7.3(a) is reasonable, valid and necessary for the adequate
protection of COH’s interest in and to the IL-13 Patent Rights, and that would not have granted to Licensee the licenses
under those IL-13 Patent Rights, without this Section 7.3(a).

 

 

*Confidential material
redacted and filed separately with the Commission.

 

    	 	20	 

     

    

 

CONFIDENTIAL

 

(b)          Payment
of COH Patent Expenses. The Parties acknowledge that, prior to the Original Effective Date, COH provided to Licensee documentation
of historic expenses incurred by COH with respect to the drafting, prosecution and maintenance of the IL-13 Patent Rights. In consideration
of such historic expenditures by COH, the Parties acknowledge and agree that Licensee has reimbursed COH for such expenses within
thirty (30) days of the Original Effective Date.

 

(c)          After
the Original Effective Date, COH shall provide to Licensee an annual invoice and reasonably detailed documentation with respect
to COH’s out-of-pocket expenses incurred with respect to such prosecution and maintenance for the previous year. Licensee
shall reimburse COH for * percent of such expenses within thirty (30) days after receipt of such invoice and documentation.

 

7.4           Marking.
Licensee and its Sublicensees shall mark all Licensed Products and all materials related to Licensed Services in such a matter
as to conform with the patent laws of the country to which such Licensed Products are shipped or in which such products are sold
and such Licensed Services performed.

 

ARTICLE
8: TERM AND TERMINATION

 

8.1           Term
and Expiration of Term. The term of this Agreement (the “Term”) shall commence on the A&R Effective
Date and, notwithstanding any other provision of this Agreement, unless sooner terminated by mutual agreement or pursuant to any
other provision of this Agreement, this Agreement shall expire on a country-by-country basis and on a IL-13 Patent Right-by- IL-13
Patent Right basis on the later to occur of: (a) the expiration of the last to expire of any of the IL-13 Patent Rights in such
country (or if no patent issues, until the last patent application in IL-13 Patent Rights is abandoned), and (b) the date on which
the last of the remaining obligations under this Agreement between the Parties with respect to the payment of milestones or royalties
with respect to Licensed Products and Licensed Services have been satisfied (such expiry of the Term hereinafter referred to as
“Expiration”).

 

8.2           Termination.

 

8.2.1           Material
Breach. Either Party may terminate this Agreement prior to its Expiration for any material breach by the other Party, provided,
that, the Party seeking to terminate shall have first given the breaching Party notice of such material breach with reasonable
particulars of the material breach, and the Party receiving the notice of the material breach shall have failed to cure that material
breach within thirty (30) days after the date of receipt of such notice.

 

8.2.2           Bankruptcy.
COH shall have the right to terminate this Agreement prior to its Expiration upon notice to Licensee, in the event that: (i) Licensee
seeks protection of any bankruptcy or insolvency law other than with the prior consent of City of Hope, or (ii) a proceeding in
bankruptcy or insolvency is filed by or against Licensee and not withdrawn, removed or vacated within 120 days of such filing,
or there is adjudication by a court of competent jurisdiction that Licensee is bankrupt or insolvent.

 

 

*Confidential material redacted and filed separately
with the Commission.

 

    	 	21	 

     

    

 

CONFIDENTIAL

 

8.2.3           Termination
at Will by Licensee. Licensee shall have the right to terminate this Agreement prior to its Expiration upon notice to COH
without cause, effective no fewer than 90 days following the date of such notice.

 

8.2.4           Breach-Based
Termination of CTA. Licensee and COH hereby acknowledge and agree that in the event that COH terminates the CTA pursuant
to Section 11(a) or Section 4(b) of the CTA, Licensee’s rights to the CTA Inventions and the Study Data under this Agreement
shall automatically terminate as of the effective date of termination of the CTA; provided, that in the event of
any such termination of the CTA by COH, Licensee shall provide written notice to COH within thirty (30) days of such termination.

 

8.3           Effect
of Termination.

 

8.3.1           Upon
any termination of this Agreement pursuant to Section 8.2 (but for clarity, not in the case of its Expiration), all rights and
licenses granted to Licensee under Article 4, if any, shall immediately terminate on and as of the effective date of termination
as provided in Section 8.2, except that Licensee shall have the right to continue to sell Licensed Products manufactured prior
to the effective date of such termination until the sooner of: (i) ninety (90) days after the effective date of termination, or
(ii) the exhaustion of Licensee’s inventory of Licensed Products.

 

8.3.2           Upon
termination of this Agreement pursuant to Section 8.2 (but for clarity, not in the case of its Expiration):

 

   (a)          Each
Party shall promptly return to the other Party all relevant records and materials in its possession or control containing or comprising
the other Party’s Confidential Information and to which the Party does not retain rights hereunder.

 

   (b)          Licensee
shall discontinue making any representation regarding its status as a licensee of COH for Licensed Products and Licensed Services.
Subject to Section 8.3.1, above, Licensee shall cease conducting any activities with respect to the marketing, promotion, sale
or distribution of Licensed Products and Licensed Services.

 

8.3.3           Termination
of this Agreement through any means and for any reason pursuant to Section 8.2 (but for clarity, not in the case of its Expiration),
shall not relieve the Parties of any obligation accruing prior thereto, including the payment of all sums due and payable, and
shall be without prejudice to the rights and remedies of either Party with respect to any antecedent breach of any of the provisions
of this Agreement.

 

8.4           Effect
of Expiration. In the event of Expiration of this Agreement for a particular Licensed Product (or Licensed Service) in
a particular country pursuant to Section 8.1, the rightsand licenses granted to Licensee under this Agreement with respect to the
Study Data in such country shall become nonexclusive, perpetual, irrevocable, and royalty-free.

 

    	 	22	 

     

    

 

CONFIDENTIAL

 

8.5           Survival.
Sections 4.11, 5.1, 5.2, 5.3, 7.4, 8.3, 8.4, 8.5, Article 10, Article 11, Article 12, Sections 14.2, 14.4, 14.7, and 14.10 shall
survive termination of this Agreement for any reason pursuant to Section 8.2 and Expiration pursuant to Section 8.1.

 

ARTICLE
9: REPRESENTATIONS AND WARRANTIES

 

9.1           Mutual
Representations and Warranties. COH and Licensee each represents and warrants as follows:

 

9.1.1           It
has the right and authority to enter into this Agreement and all action required to be taken on its behalf, its officers, directors,
partners and stockholders necessary for the authorization, execution, and delivery of this Agreement and, the performance of all
of its obligations hereunder, and this Agreement, when executed and delivered, will constitute valid and legally binding obligations
of such Party, enforceable in accordance with its terms, subject to: (i) laws limiting the availability of specific performance,
injunctive relief, and other equitable remedies; and (ii) bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance
or other similar laws now or hereafter in effect generally relating to or affecting creditors’ rights generally;

 

9.1.2           Entry
into this Agreement will not constitute a breach of any other agreement to which it is party;

 

9.1.3           It
has read this Agreement, with assistance from its counsel of choice. It understands all of this Agreement’s terms. It has
been given a reasonable amount of time to consider the contents of this Agreement before each Party executed it. It agrees that
it is executing this Agreement voluntarily with full knowledge of this Agreement’s legal significance; and

 

9.1.4           It
has made such investigation of all matters pertaining to this Agreement that it deems necessary, and does not rely on any statement,
promise, or representation, whether oral or written, with respect to such matters other than those expressly set forth herein.
It agrees that it is not relying in any manner on any statement, promise, representation or understanding, whether oral, written
or implied, made by any Party, not specifically set forth in this Agreement. It acknowledges that, after execution of this Agreement,
it may discover facts different from or in addition to those which it now knows or believes to be true. Nevertheless, it agrees
that this Agreement shall be and remain in full force and effect in all respects, notwithstanding such different or additional
facts.

 

9.2           Representations
and Warranties of COH. COH represents and warrants that, as of the Original Effective Date, to the actual knowledge of
the Investigator (as defined in the Research Agreement) and the Director of its Office of Technology Transfer without independent
inquiry, COH has the full power and authority to grant the rights, licenses and privileges granted herein.

 

    	 	23	 

     

    

 

CONFIDENTIAL

 

9.3           Representations
and Warranties of Licensee. Licensee represents and warrants as of the Original Effective Date (except as specifically
provided below) and as of the A&R Effective Date (except as specifically provided below):

 

9.3.1           all
authorizations necessary for the issuance of the COH Shares and the Common Stock issuable to COH upon conversion of the COH Shares
have been obtained;

 

9.3.2           no
consent, approval, order, or authorization of, or registration, qualification, designation, declaration, or filing with, any federal,
state, or local governmental authority on the part of Licensee was required in connection with the offer, sale, or issuance of
the COH Shares (and the Common Stock issuable upon conversion of the COH Shares) or the consummation of any other transaction contemplated
hereby, except for the following: (i) the filing of a notice of exemption pursuant to Section 25102(f) of the California Corporate
Securities Law of 1968, as amended, which was filed by Licensee promptly following the Original Effective Date and promptly following
any Measurement Date; and (ii) the compliance with other applicable state securities laws, which compliance has occurred or will
occur within the appropriate time periods therefor. The offer, sale, and issuance of the COH Shares are exempt from the registration
requirements of Section 5 of the Act, and from the qualification requirements of Section 25110 of the California Securities Law,
and neither Licensee, nor any authorized agent acting on its behalf has taken or will take any action hereafter that results in
the loss of such exemptions;

 

9.3.3           The
sale of the COH Shares was not, and the subsequent conversion of the COH Shares into Common Stock will not be, subject to any preemptive
rights or rights of first refusal that have not been properly waived or complied with;

 

9.3.4           The
COH Shares, when issued, sold and delivered in accordance with the terms of the Original Agreement or this Agreement for the consideration
expressed therein, were and will be duly and validly issued, fully paid and nonassessable and free of restrictions on transfer,
other than restrictions on transfer under applicable state and federal securities laws. The Common Stock issuable upon conversion
of the COH Shares has been duly and validly reserved for issuance and, upon issuance in accordance with the terms of the Charter,
will be duly and validly issued, fully paid and nonassessable and free of restrictions on transfer other than restrictions on transfer
under applicable state and federal securities laws. 

 

9.3.5           As
of the A&R Effective Date, the authorized capital stock of Licensee consists of (i) 50,000,000 shares of Common Stock (24,209,0251
of which shall be issued and outstanding after giving effect to the issuances contemplated hereunder); of which 1,000,000 shares
were designated as Class A Common Stock (1,000,000 of which are issued and outstanding (taking into account the issuance of the
COH Shares of Class A Common Stock pursuant to the Original Agreement)), and (ii) 2,000,000 shares of preferred stock, 250,000
of which are designated as Series A Preferred Stock (250,000 of which are issued and outstanding). As of the A&R Effective
Date there are outstanding warrants exercisable for 4,239,396 shares of Common Stock at an exercise price of $8.50 per share and
138,462 shares of Common Stock at an exercise price of $0.0001. As of the A&R Effective Date, Licensee has also reserved but
has not issued an aggregate of 2,000,000 shares of Common Stock for issuance to employees, directors and consultants pursuant to
Licensee’s equity incentive compensation plans. As of the A&R Effective Date, all issued and outstanding shares were
duly authorized and validly issued and were fully paid and nonassessable. Other than as provided in this Section 9.3.5 or pursuant
to litigation as described in the Company’s filings with the Securities and Exchange Commission prior to the date hereof,
there are no other outstanding rights, options, warrants, preemptive rights, rights of first refusal, or similar rights for the
purchase or acquisition from Licensee of any securities of Licensee nor any commitments to issue or execute any such rights, options,
warrants, preemptive rights or rights of first refusal. The respective rights, preferences, privileges, and restrictions of the
Common Stock, including the Class A Common Stock and the preferred stock, are solely as stated in the Charter. As of the Original
Effective Date, the COH Shares represented a 10% interest in the capital stock of Licensee; and

 

 

1
To be confirmed by Mustang

 

    	 	24	 

     

    

 

CONFIDENTIAL

 

9.3.6           Licensee
is not in violation or default of any provision of the Charter or its bylaws.

 

9.4          Exclusions.
Nothing in this Agreement is or shall be construed as:

 

9.4.1           A
warranty or representation by COH as to the validity or scope of any claim or patent or patent application within the IL-13 Patent
Rights;

 

9.4.2           A
warranty or representation by COH that anything made, used, sold, or otherwise disposed of under any license granted in this Agreement
is or will be free from infringement of any patent rights or other intellectual property right of any Third Party;

 

9.4.3           A
grant by COH, whether by implication, estoppel, or otherwise, of any licenses or rights under any patents other than IL-13 Patent
Rights as defined herein, regardless of whether such patents are dominant or subordinate to IL-13 Patent Rights;

 

9.4.4           An
obligation on COH to bring or prosecute any suit or action against a third party for infringement of any of the IL-13 Patent Rights;

 

9.4.5           An
obligation to furnish any know-how not provided in IL-13 Patent Rights or the Study Data; or

 

9.4.6           A
representation or warranty of the ownership of the IL-13 Patent Rights or the Study Data other than as set forth in Section 9.2,
above.

 

9.5           DISCLAIMER.
NO WARRANTY IS GIVEN WITH RESPECT TO THE IL-13 PATENT RIGHTS OR THE STUDY DATA, EXPRESS OR IMPLIED, EITHER IN FACT OR BY OPERATION
OF LAW, BY STATUTE OR OTHERWISE, AND THE PARTIES SPECIFICALLY DISCLAIM ANY EXPRESS OR IMPLIED WARRANTY OF MERCHANTABILITY, FITNESS
FOR A PARTICULAR PURPOSE, VALIDITY OF THE IL-13 PATENT RIGHTS OR NON-INFRINGEMENT OF THE INTELLECTUAL PROPERTY OR OTHER RIGHTS
OF ANY THIRD PARTY. THE WARRANTIES SET FORTH IN SECTIONS 9.1 AND 9.2, ABOVE, ARE IN LIEU OF ALL OTHER WARRANTIES, EXPRESS OR IMPLIED,
INCLUDING BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, VALIDITY, NON-INFRINGEMENT
AND ALL SUCH OTHER WARRANTIES ARE HEREBY EXPRESSLY DISCLAIMED.

 

    	 	25	 

     

    

 

CONFIDENTIAL

 

ARTICLE
10: INDEMNIFICATION

 

10.1         Indemnification
by Licensee. Licensee shall defend, indemnify and hold harmless COH, its Affiliates, officers, directors, shareholders,
employees and agents (“COH Indemnitees”) from and against any and all Third Party liabilities, claims, suits,
and expenses, including reasonable attorneys’ fees (collectively, “Losses”), arising out of or are in
any way attributable to: (i) the material breach of any representation or warranty made by Licensee under this Agreement, (ii)
the research, development, marketing, approval, manufacture, packaging, labeling, handling, storage, transportation, use, distribution,
promotion, marketing or sale of Licensed Products or Licensed Services by or on behalf of Licensee, any of its Affiliates or a
Sublicensee or any other exercise of rights under this Agreement or pursuant to any sublicense, or (iii) the negligence, willful
misconduct or failure to comply with applicable law by a Licensee Indemnitee or Sublicensee; in each case except to the extent
that such Losses are caused directly by: (a) COH’s material breach of any representation or warranty made by COH under this
Agreement, (b) COH’s material breach of its obligations under this Agreement, and/or (c) the gross negligence or willful
misconduct of a COH Indemnitee.

 

10.2         Indemnification
by COH. COH shall defend, indemnify and hold harmless Licensee and its Affiliates and their respective officers, directors,
shareholders, employees and agents (collectively, the “Licensee Indemnitees”) from and against any and all Losses
caused directly by: (i) the material breach of any representation or warranty made by COH under this Agreement, or (ii) the gross
negligence or willful misconduct of a COH Indemnitee, except to the extent that such Losses arise out of or are in any way attributable
to: (a) the material breach of any representation or warranty made by Licensee under this Agreement, (b) the research, development,
marketing, approval, manufacture, packaging, labeling, handling, storage, transportation, use, distribution, promotion, marketing
or sale of Licensed Products or Licensed Services by or on behalf of Licensee or a Sublicensee, or (c) the negligence, willful
misconduct or failure to comply with applicable law by a Licensee Indemnitee or a Sublicensee.

 

10.3         Procedure.
The indemnities set forth in this Article 10 are subject to the condition that the Party seeking the indemnity shall forthwith
notify the indemnifying Party on being notified or otherwise made aware of a liability, claim, suit, action or expense and that
the indemnifying Party defend and control any proceedings with the other Party being permitted to participate at its own expense
(unless there shall be a conflict of interest which would prevent representation by joint counsel, in which event the indemnifying
Party shall pay for the other Party’s counsel); provided, that, the indemnifying Party may not settle the liability,
claim, suit, action or expense, or otherwise admit fault of the other Party or consent to any judgment, without the written consent
of the other Party (such consent not to be unreasonably withheld). Notwithstanding the foregoing, no delay in the notification
of the existence of any claim of Loss shall cause a failure to comply with this Section 10.3 as long as such delay shall not have
materially impaired the rights of the indemnifying Party.

 

    	 	26	 

     

    

 

CONFIDENTIAL

 

10.4         Insurance.

 

(a)          Within
thirty (30) days following the Effective Date, Licensee shall procure at its sole expense and provide to COH evidence of comprehensive
or commercial general liability insurance (contractual liability included) with limits of at least: (i) each occurrence, $*;
 (ii) products/completed operations aggregate, $*; (iii) personal and advertising injury, $*; and general aggregate (commercial
form only), $*.

 

(b)          The
foregoing policies will provide primary coverage to COH and shall name the COH Indemnitees as additional insureds, and shall remain
in effect during the term of this Agreement and for * years following the termination or expiration of the term of this Agreement.
The COH Indemnitees shall be notified in writing by Licensee not less than thirty (30) days prior to any modification, cancellation
or non-renewal of such policy. Licensee’s insurance must include a provision that the coverages will be primary and will
not participate with nor will be excess over any valid and collective insurance or program of self-insurance carried or maintained
by the COH Indemnitees. Such insurance coverage shall be maintained with an insurance company or companies having an A.M. Best’s
rating (or its equivalent) of A-XII or better.

 

(c)          Licensee
expressly understands that the coverage limits in Section 10.4(a) do not in any way limit the Licensee’s liability.

 

10.5         LIMITATION
ON DAMAGES.  NOTWITHSTANDING ANYTHING CONTAINED IN THIS AGREEMENT TO THE CONTRARY, EXCEPT IN RELATION TO LICENSEE’S
INDEMNIFICATION OBLIGATIONS UNDER SECTION 10.1 AND ANY BREACH BY LICENSEE OF ARTICLE 11: (I) IN NO EVENT SHALL EITHER PARTY BE
LIABLE FOR ANY SPECIAL, PUNITIVE, CONSEQUENTIAL, INDIRECT, OR INCIDENTAL DAMAGES (INCLUDING LOSS OF PROFITS, COSTS OF PROCURING
SUBSTITUTE GOODS, LOST BUSINESS OR ENHANCED DAMAGES FOR INTELLECTUAL PROPERTY INFRINGEMENT) WHETHER BASED UPON BREACH OF WARRANTY,
BREACH OF CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR ANY OTHER LEGAL THEORY, AND (II) IN NO EVENT SHALL COH BE LIABLE TO
LICENSEE FOR AN AGGREGATE AMOUNT IN EXCESS OF TWO-THIRDS OF THE TOTAL CONSIDERATION PAID TO COH HEREUNDER. 

 

ARTICLE
11: CONFIDENTIALITY

 

11.1         Confidential
Information.     During the term of this Agreement and for * (*) * thereafter without regard to the means of termination: (i)
COH shall not use, for any purpose other than the purpose contemplated by this Agreement, or reveal or disclose to any Third Party
Licensee Confidential Information; and (ii) Licensee shall not use, for any purpose other than the purpose contemplated by this
Agreement, or reveal or disclose COH Confidential Information to any Third Party. The Parties shall take reasonable measures to
assure that no unauthorized use or disclosure is made by others to whom access to such information is granted.

 

11.2         Exceptions.      Notwithstanding
the foregoing, a Party may use and disclose Confidential Information of the other Party as follows:

 

 

*Confidential material redacted and filed separately
with the Commission.

 

    	 	27	 

     

    

 

CONFIDENTIAL

 

(a)          if
required by applicable law, rule, regulation, government requirement and/or court order, provided, that, the disclosing
Party promptly notifies the other Party of its notice of any such requirement and provides the other Party a reasonable opportunity
to seek a protective order or other appropriate remedy and/or to waive compliance with the provisions of this Agreement;

 

(b)          to
the extent such use and disclosure occurs in the filing or publication of any patent application or patent on inventions;

 

(c)          as
necessary or desirable for securing any regulatory approvals, including pricing approvals, for any Licensed Products or Licensed
Services, provided, that, the disclosing Party shall take all reasonable steps to limit disclosure of the Confidential
Information outside such regulatory agency and to otherwise maintain the confidentiality of the Confidential Information;

 

(d)          to
take any lawful action that it deems necessary to protect its interest under, or to enforce compliance with the terms and conditions
of, this Agreement;

 

(e)          to
the extent necessary, to its Affiliates, directors, officers, employees, consultants, vendors and clinicians under written agreements
of confidentiality at least as restrictive as those set forth in this Agreement, who have a need to know such information in connection
with such Party performing its obligations or exercising its rights under this Agreement; and

 

(f)          by
Licensee, to actual and potential investors, licensees, Sublicensees, consultants, vendors and suppliers, and academic and commercial
collaborators, under written agreements of confidentiality at least as restrictive as those set forth in this Agreement.

 

11.3         Certain
Obligations. During the Term and for a period of * (*) * thereafter and subject to the exceptions set forth
in Section 11.2, Licensee, with respect to COH Confidential Information, and COH, with respect to Licensee Confidential Information,
agree:

 

(a)          to
use such Confidential Information only for the purposes contemplated under this Agreement,

 

(b)          to
treat such Confidential Information as it would its own proprietary information which in no event shall be less than a reasonable
standard of care,

 

(c)          to
take reasonable precautions to prevent the disclosure of such Confidential Information to a Third Party without written consent
of the other Party, and

 

(d)          to
only disclose such Confidential Information to those employees, agents and Third Parties who have a need to know such Confidential
Information for the purposes set forth herein and who are subject to obligations of confidentiality no less restrictive than those
set forth herein.

 

 

*Confidential material redacted and filed separately
with the Commission.

 

    	 	28	 

     

    

 

CONFIDENTIAL

 

11.4         Termination.
Upon termination of this Agreement pursuant to Section 8.2 (but for clarity, not in the case of its Expiration), and upon the request
of the disclosing Party, the receiving Party shall promptly return to the disclosing Party or destroy all copies of Confidential
Information received from such Party, and shall return or destroy, and document the destruction of, all summaries, abstracts, extracts,
or other documents which contain any Confidential Information of the other Party in any form, except that each Party shall be permitted
to retain a copy (or copies, as necessary) of such Confidential Information for archival purposes or to enforce or verify compliance
with this Agreement, or as required by any applicable law or regulation.

 

ARTICLE
12: DISPUTE RESOLUTION

 

All Disputes shall be first referred to a Vice
President, Center for Applied Technology Development of COH (the “COH VP”) and the President of Licensee for
resolution, prior to proceeding under the other provisions of this Article 12. A Dispute shall be referred to such executives upon
one Party (the “Initiating Party”) providing the other Party (the “Responding Party”) with
notice that such Dispute exists, together with a written statement describing the Dispute with reasonable specificity and proposing
a resolution to such Dispute that the Initiating Party is willing to accept, if any. Within ten days after having received such
statement and proposed resolution, if any, the Responding Party shall respond with a written statement that provides additional
information, if any, regarding such Dispute, and proposes a resolution to such Dispute that the Responding Party is willing to
accept, if any. In the event that such Dispute is not resolved within 60 days after the Responding Party’s receipt of the
Initiating Party’s notice, either Party may bring and thereafter maintain suit against the other with respect to such Dispute;
provided, however, that the exclusive jurisdiction of any such suit shall be the state and federal courts located in Los Angeles
County, California, and the Parties hereby consent to the exclusive jurisdiction and venue of such courts.

 

ARTICLE
13: GOVERNMENTAL MATTERS

 

13.1         Governmental
Approval or Registration. If this Agreement or any associated transaction is required by the law of any nation to be either
approved or registered with any governmental agency, Licensee shall assume all legal obligations to do so. Licensee shall notify
COH if it becomes aware that this Agreement is subject to a U.S. or foreign government reporting or approval requirement. Licensee
shall make all necessary filings and pay all costs including fees, penalties and all other out-of-pocket costs associated with
such reporting or approval process.

 

13.2         Export
Control Laws. Licensee shall observe all applicable U.S. and foreign laws with respect to the transfer of Licensed Products
and related technical data to foreign countries, including, without limitation, the International Traffic in Arms Regulations and
the Export Administration Regulations.

 

13.3         Preference
for United States Industry. If Licensee sells a Licensed Product in the U.S., Licensee shall manufacture said product substantially
in the U.S.

 

    	 	29	 

     

    

 

CONFIDENTIAL

 

ARTICLE
14: MISCELLANEOUS

 

14.1         Assignment
and Delegation. Except as expressly provided in this Section 14.1, neither this Agreement nor any right or obligation hereunder
shall be assignable in whole or in part, whether by operation of law, or otherwise by Licensee without the prior written consent
of COH. Notwithstanding the foregoing, Licensee may assign or transfer its rights and obligations under this Agreement to a Person
that succeeds to all or substantially all of that Party’s business or assets, whether by sale, merger, operation of law or
otherwise and provided that such Person agrees, in form and substance reasonably acceptable to COH, to be bound as a direct party
to this Agreement in lieu of or in addition to Licensee and provided further that Licensee has complied with its obligations pursuant
to Section 4.5. This Agreement shall be binding upon and inure to the benefit of and be enforceable by the Parties hereto and their
respective successors and permitted assignees. Any transfer or assignment of this Agreement in violation of this Section 14.1 shall
be null and void.

 

14.2         Entire
Agreement. This Agreement contains the entire agreement between the Parties relating to the subject matter hereof, and
all prior understandings, representations and warranties between the Parties are superseded by this Agreement. For clarity, the
Original Agreement shall be deemed amended and restated in its entirety by this Agreement, and the corresponding A&R
CD123 License and the corresponding A&R Spacer License to be executed by the Parties simultaneously herewith, effective
as of the A&R Effective Date.

 

14.3         Amendments.
Changes and additional provisions to this Agreement shall be binding on the Parties only if agreed upon in writing and signed by
the Parties.

 

14.4         Applicable
Law. This Agreement shall be construed and interpreted in accordance with the laws of the State of California and all rights
and remedies shall be governed by such laws without regard to principles of conflicts of law.

 

14.5         Force
Majeure. If the performance of this Agreement or any obligations hereunder is prevented, restricted or interfered with
by reason of earthquake, fire, flood or other casualty or due to strikes, riot, storms, explosions, acts of God, war, terrorism,
or a similar occurrence or condition beyond the reasonable control of the Parties, the Party so affected shall, upon giving prompt
notice to the other Parties, be excused from such performance during such prevention, restriction or interference, and any failure
or delay resulting therefrom shall not be considered a breach of this Agreement.

 

14.6         Severability.
The Parties do not intend to violate any public policy or statutory common law. However, if any sentence, paragraph, clause or
combination of this Agreement is in violation of any law or is found to be otherwise unenforceable, such sentence, paragraph, clause
or combination of the same shall be deleted and the remainder of this Agreement shall remain binding, provided that
such deletion does not alter the basic purpose and structure of this Agreement.

 

14.7         Notices.
All notices, requests, demands, and other communications relating to this Agreement shall be in writing in the English language
and shall be delivered in person or by mail, international courier or facsimile transmission (with a confirmation copy forwarded
by courier or mail). Notices sent by mail shall be sent by first class mail or the equivalent, registered or certified, postage
prepaid, and shall be deemed to have been given on the date actually received. Notices sent by international courier shall be sent
using a service which provides traceability of packages. Notices shall be sent as follows:

 

    	 	30	 

     

    

 

CONFIDENTIAL

 

	
        Notices to COH:

         

        Office of Technology Licensing

        City of Hope

        1500 East Duarte Road

        Duarte, CA 91010

        Attn: Sr. VP, Center for Applied Technology Development

        Fax: 626-301-8175

         
	
        with a copy to:

         

        Office of General Counsel

        City of Hope

        1500 East Duarte Road

        Duarte, CA 91010

        Attn: General Counsel

        Fax: 626-301-8863

	
        Notices to Licensee:

         

        Mustang Bio, Inc.

        2 Gansevoort, 9th Floor

        New York, NY 10014

        Attn: CEO
	with a copy to:

         

        Mustang Bio, Inc.

        2 Gansevoort, 9th Floor

        New York, NY 10014

        Attn: Corporate Secretary

 

Either Party may change its address for notices
or facsimile number at any time by sending notice to the other Party.

 

14.8         Independent
Contractor. Nothing herein shall create any association, partnership, joint venture, fiduciary duty or the relation of
principal and agent between the Parties hereto, it being understood that each Party is acting as an independent contractor, and
neither Party shall have the authority to bind the other or the other’s representatives in any way.

 

14.9         Waiver.
No delay on the part of either Party hereto in exercising any power or right hereunder shall operate as a waiver thereof, nor shall
any single or partial exercise of any power or right hereunder preclude other or further exercise thereof or the exercise of any
other power or right. No waiver of this Agreement or any provision hereof shall be enforceable against any Party hereto unless
in writing, signed by the Party against whom such waiver is claimed, and shall be limited solely to the one event.

 

14.10         Interpretation.
This Agreement has been prepared jointly and no rule of strict construction shall be applied against either Party. In this Agreement,
the singular shall include the plural and vice versa and the word “including” shall be deemed to be followed by the
phrase “without limitation.” The section headings contained in this Agreement are inserted for convenience only and
shall not affect in any way the meaning or interpretation of this Agreement.

 

14.11         Counterparts.
This Agreement may be executed in counterparts, each of which together shall constitute one and the same Agreement. For purposes
of executing this agreement, a facsimile copy or an emailed PDF of this Agreement, including the signature pages, will be deemed
an original.

 

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CONFIDENTIAL

 

14.12         Licensee
Certification. Licensee certifies to COH, under penalty of perjury, that Licensee has not been convicted of a criminal
offense related to health care, is not currently debarred, excluded or otherwise ineligible for participation in federally funded
health care programs and has not arranged or contracted (by employment or otherwise) with any employee, contractor, or agent that
it knew or should have known are excluded from participation in any federal health care program, and will not knowingly arrange
or contract with any such individuals or entities during the term of this Agreement. Licensee agrees to notify COH in writing immediately
of any threatened, proposed or actual conviction relating to health care, of any threatened, proposed or actual debarment or exclusion
from participation in federally funded programs, of COH or any employee, contractor or agent of COH.  Any breach of this
Section 14.12 by Licensee shall be grounds for termination of this Agreement by COH in accordance with Section 8.2.1.

 

14.13         Publicity.
Neither Party may issue a press releases or otherwise disclose the existence or terms of this Agreement without the prior written
consent of the other Party; provided, however, that once the existence or any terms or conditions of this Agreement
has been publicly disclosed in a manner mutually and reasonably agreed-to by the Parties, either Party may republish the facts
previously disclosed without the prior consent of the other Party. COH may, in its sole discretion and without the approval of
Licensee, publicly disclose the existence of this Agreement and the overall potential value of the Agreement to COH, so long as
the detailed and specific terms and conditions of this Agreement are not disclosed. If a third party inquires whether a license
is available, COH may disclose the existence of the Agreement and the extent of its grant in Section 3.1 to such third party, but
will not disclose the name of the Licensee, except where COH is required to release information under either the California Public
Records Act or other applicable law. Notwithstanding the foregoing, COH may disclose an unredacted copy of this Agreement as required
under applicable law and other obligations as applicable to the CIRM Grant.

 

*        *        *        *        *

 

    	 	32	 

     

    

 

CONFIDENTIAL

 

IN WITNESS WHEREOF,
the Parties have executed this Agreement by their duly authorized representatives.

 

	MUSTANG BIO, INC.	 	
        CITY OF HOPE

	 	 	 
	By:	/s/ Michael S. Weiss	 	By:	/s/ Robert Stone
	Name	Michael S. Weiss	 	Name:	Robert Stone
	Title:	President & CEO	 	Title:	President & CEO

  

    	 	33	 

     

    

 

CONFIDENTIAL

 

EXHIBIT A

 

Form of Charter

 

    	 	34	 

     

    

 

EXHIBIT B

 

CTACONFIDENTIAL TREATMENT REQUESTED. Confidential portions of
this document have been redacted and have been separately filed with the Commission. 

 

Exhibit
10.16

 

AMENDED
AND RESTATED EXCLUSIVE LICENSE AGREEMENT – Spacer

 

THIS AMENDED AND RESTATED EXCLUSIVE
LICENSE AGREEMENT – SPACER (the “Agreement”) is made and entered into as of the 17th day
of February, 2017 (the “A&R Effective Date”) by and between Mustang Bio, Inc. (f/k/a Mustang Therapeutics,
Inc.), a Delaware corporation with a principal place of business at 2 Gansevoort, 9th Floor, New York, NY 10014 (“Licensee”)
and City of Hope, a California nonprofit public benefit corporation located at 1500 East Duarte Road, Duarte, California 91010
(“City of Hope” or “COH”). Licensee and COH are each sometimes referred to herein individually
as a “Party” and collectively as the “Parties.”

 

WHEREAS:

 

A.           COH
operates an academic research and medical center that encourages the use of its inventions, discoveries and intellectual property
for the benefit of the public, and COH owns or Controls (as defined below) certain Spacer Patent Rights (as defined below) useful
in the Field (as defined below);

 

B.           The
inventions covered by the Spacer Patent Rights were invented by Dr. Stephen Forman who, as of the A&R Effective Date, is affiliated
with COH;

 

C.           The
research was sponsored in part by the National Institute of Health, and as a consequence this license is subject to obligations
to the United States Federal Government under 35 U.S.C. §§ 200-212 and applicable U.S. government regulations;

 

D.           Licensee
is a company dedicated to the commercial development and exploitation in the Field (as defined below) of products and services
that incorporate one or more of the technologies described in the Spacer Patent Rights and therefore Licensee desires to obtain
from COH a worldwide, exclusive license under the Spacer Patent Rights, on the terms and subject to the conditions set forth herein;

 

E.           The
Certificate of Incorporation of Licensee as of the A&R Effective Date is in the form attached hereto as Exhibit A (the
“Charter”) and provides, among other things, for the rights and preferences of a class of stock, referred to
therein as Class A Common Stock, that was issued to COH or its designee(s) in accordance with the terms of the Original Agreement;

 

F.           COH
and Licensee have entered into (i) that certain Exclusive License Agreement, dated March 17, 2015 (the “Original Effective
Date”) (said agreement hereafter referred to as the “Original Agreement”), whereby COH granted to
Licensee certain exclusive rights in certain patent rights related to IL-13, CD123, and spacer technologies, and (ii) that certain
Sponsored Research Agreement between the Parties dated March 2015 (the “Research Agreement”); and

 

     

    CONFIDENTIAL

    

  

G.           COH
and Licensee now desire to amend and restate the Original Agreement, which related to certain chimeric antigen receptor (“CAR”)
technologies in connection with IL-13, CD123, and spacer technologies by entering into three separate amended and restated exclusive
license agreements, one relating to CD123 (the “A&R CD123 License”), one relating to IL-13 (the “A&R
IL-13 License”), and one relating to the spacer technology (this Agreement), that will amend the Original Agreement in
certain other respects, and collectively replace the Original Agreement in its entirety.

 

NOW, THEREFORE, in consideration
of the mutual covenants contained herein, and for other good and valuable consideration, the amount and sufficiency of which are
hereby acknowledged, the Parties hereby agree as follows:

 

ARTICLE
1: DEFINITIONS

 

1.1           “Act”
means the Securities Act of 1933, as amended.

 

1.2           “Affiliate”
of a Party means a Person that, directly or indirectly (through one or more intermediaries) controls, is controlled by, or is under
common control with such Party. For purposes of this Section 1.2, “control” means (i) the direct or indirect ownership
of 50 percent or more of the voting stock or other voting interests or interests in profits, or (ii) the ability to otherwise control
or direct the decisions of board of directors or equivalent governing body thereof.

 

1.3           “Business
Day” means any day, other than a Saturday, Sunday or day on which commercial banks located in Los Angeles, California,
are authorized or required by law or regulation to close.

 

1.4           “Change
of Control” means (i) any transaction or series of related transactions following which the holders of Licensee’s
capital stock immediately prior to such transaction or series of related transactions collectively are the owners of less than
50% of the outstanding equity interests of Licensee entitled to (a) vote with respect to the election of directors (or positions
having a similar function) or (b) receive the proceeds upon any sale, liquidation or dissolution of Licensee, (ii) a sale, transfer,
exclusive license or other disposition, in a single transaction or series of related transactions, of all or a material portion
of Licensee’s interest in the Licensed Product or Licensed Service or (iii) a sale, transfer, exclusive license or other
disposition, in a single transaction or series of related transactions, of all or a material portion of Licensee’s right
title, or interest in its assets taken as a whole.

 

1.5           “Class
A Common Stock” means Class A Common Stock, par value $0.0001 per share, of Licensee, with such rights preferences
and privileges as are set forth in the Charter.

 

1.6           “COH
CAR” means a CAR that is licensed to Licensee by COH pursuant to an applicable license agreement between the Parties,
including but not limited to, pursuant to the A&R IL-13 License and the A&R CD123 License.

 

1.7           “COH
Confidential Information” means Confidential Information disclosed or provided by, or on behalf of, COH to Licensee
or its designees.

 

    	 	-2-	 

    CONFIDENTIAL

    

  

1.8           “COH
Shares” means the shares of Class A Common Stock issued and to be issued to COH Stockholders in accordance with Section
4.3 of the Original Agreement and this Agreement and/or the terms of the Charter.

 

1.9           “COH
Spacer Technology” means any spacer, hinge, or linker sequence(s) that is used to connect the *; of an applicable
CAR and that is Covered by a Valid Claim.

 

1.10         “Commercially
Reasonable Efforts” means the exercise of such efforts and commitment of such resources by Licensee, directly or
through one or more Sublicensees, in a diligent manner consistent with organizations in the pharmaceutical industry for a comparable
development or commercialization program at a similar stage of development or commercialization. In the event that Licensee or
a Sublicensee with respect to a given Licensed Product or Licensed Service, has a program or product that competes with the programs
contemplated by this Agreement with respect to such Licensed Product or Licensed Service, then “Commercially Reasonable Efforts”
shall also mean efforts at least comparable to those efforts and resources expended by Licensee or its Sublicensee on the competing
program and/or product or service.

 

1.11         “Completion”
means, with respect to a particular clinical trial, the earlier of (i) the database lock or freeze related to the completion of
treatment or examination of participants in such clinical trial or (ii) the dosing of the first patient in a clinical trial in
a subsequent phase (e.g., with respect to a Phase 1 Clinical Trial, the Phase 1 Clinical Trial will be deemed completed
in the event a patient is dosed in a Phase 2 Clinical Trial before a database lock in the related Phase 1 Clinical Trial).

 

1.12         “Common
Stock” means Common Stock, par value $0.0001 per share, of Licensee.

 

1.13         “Confidential
Information” means: (i) all information and materials (of whatever kind and in whatever form or medium) disclosed
by or on behalf of a Party to the other Party (or its designee) in connection with this Agreement, whether prior to or during the
term of this Agreement and whether provided orally, electronically, visually, or in writing; provided that all such information
and materials initially disclosed in writing or electronically shall be clearly marked as “CONFIDENTIAL” and all such
materials and information initially disclosed orally shall be reduced to writing and marked as “CONFIDENTIAL” within
10 days following the date of initial oral disclosure; (ii) all copies of the information and materials described in (i) above;
and (iii) the existence and each of the terms and conditions of this Agreement; provided further that Confidential Information
shall not include information and materials to the extent a Party can demonstrate through its contemporaneous written records that
such information and materials are or have been:

 

(a)          known
to the receiving Party, or in the public domain, at the time of its receipt by a Party, or which thereafter becomes part of the
public domain other than by virtue of a breach of this Agreement or the obligations of confidentiality under this Agreement;

 

 

*Confidential material redacted
and filed separately with the Commission.

 

    	 	-3-	 

    CONFIDENTIAL

    

 

(b)          received
without an obligation of confidentiality from a Third Party having the right to disclose without restrictions such information;

 

(c)          independently
developed by the receiving Party without use of or reference to Confidential Information disclosed by the other Party; or

 

(d)          released
from the restrictions set forth in this Agreement by the express prior written consent of the disclosing Party.

 

1.14        “Control(s)”
or “Controlled” means the possession by a Party, as of the A&R Effective Date, of rights sufficient
to effect the grant of rights set forth in this Agreement without violating the terms of any agreement with any Third Party.

 

1.15        “Covers”
or “Covered by,” means with reference to a particular Licensed Product or Licensed Service that the manufacture,
use, sale, offering for sale, or importation of such Licensed Product or performance of such Licensed Service would, but for ownership
of, or a license granted under this Agreement to, the relevant Patent Right, infringe a Valid Claim in the country in which the
activity occurs.

 

1.16        “Dispute”
means any controversy, claim or legal proceeding arising out of or relating to this Agreement, or the interpretation, breach, termination,
or invalidity thereof.

 

1.17        “Field”
means the treatment and diagnosis of all human diseases.

 

1.18        “First
Commercial Sale” means, with respect to a particular Licensed Product or Licensed Service in a given country, the
first arm’s-length commercial sale of such Licensed Product or the first performance of such Licensed Service following Marketing
Approval in such country by or under authority of Licensee or any Sublicensee to a Third Party who is not a Sublicensee.

 

1.19        “GAAP”
means generally accepted accounting principles, consistently applied, as promulgated from time to time by the Financial Accounting
Standards Board.

 

1.20        “License
Year” means each calendar year during the term of this Agreement; except that the first License Year shall commence
on the Original Effective Date and end on December 31 of the calendar year in which the Original Effective Date occurs.

 

1.21        “Licensed
Product” means a product (including kits, component sets or components thereof, regardless of concentration or formulation)
that: (i) is Covered by a Valid Claim, (ii) is manufactured by a process or used in a method Covered by a Valid Claim, or (iii)
contains, as an active ingredient, any substance the manufacture, use, offer for sale or sale of which is Covered by a Valid Claim.
By way of clarification, “Licensed Product” shall include a product manufactured in a country in which such manufacture
is Covered by a Valid Claim and thereafter exported to and sold in a country in which no Valid Claim exists.

 

1.22        “Licensed
Service” means any service the performance of which would, but for the license granted herein, infringe a Valid Claim.

 

    	 	-4-	 

    CONFIDENTIAL

    

  

1.23        “Licensee
Confidential Information” means Confidential Information disclosed or provided by, or on behalf of, Licensee to COH
or its designees.

 

1.24        “Marketing
Approval” means all approvals, licenses, registrations or authorizations of any federal, state or local regulatory
agency, department, bureau or other governmental entity, necessary for the manufacturing, use, storage, import, transport, marketing
and sale of Licensed Products or performance of Licensed Services in a country or regulatory jurisdiction.

 

1.25        “Net
Proceeds” means the net proceeds actually received by Licensee from all sales of shares of capital stock after deduction
of all transaction expenses, finder’s fees, advisory fees, legal fees, sales commissions or similar amounts paid to brokers
or dealers and other costs and expenses incurred by Licensee or its subsidiaries in connection therewith. In the event such net
proceeds are not paid to Licensee in cash, the value of such net proceeds will be the fair market value of the assets constituting
such net proceeds.

 

1.26        “Net
Sales” means the total gross amount invoiced by Licensee, its Affiliates and its Sublicensees (regardless of whether
and when such invoices are actually paid) on the sale of Licensed Products and Licensed Services to Third Parties (including, without
limitation, the provision of any product by Licensee, its Affiliates or any of its Sublicensee that incorporates a Licensed Product
or Licensed Service but for clarity excluding documented sponsored research and/or development activities, valued at the actual
direct cost of such activities on a fully burdened basis (including reasonable margin for overhead)), less the following items,
as determined from the books and records of Licensee, its Affiliates or its Sublicensees:

 

(a)          insurance,
handling and transportation charges actually invoiced;

 

(b)          amounts
repaid, credited or allowed for rejection, return or recall;

 

(c)          sales
or other excise taxes or other governmental charges levied on or measured by the invoiced amount (including, without limitation,
value added taxes);

 

(d)          brokerage,
customs and import duties or charges; and

 

(e)          normal
and customary trade and quantity discounts (including chargebacks and allowances) and rebates which relate to the Licensed Products
or Licensed Services.

 

Sales of Licensed Products between or among
Licensee, its Affiliates or its Sublicensees shall be excluded from the computation of Net Sales, except in those instances in
which the purchaser is also the end-user of the Licensed Product sold. Further, transfers of reasonable quantities of Licensed
Product by Licensee, any of its Affiliates or of its Sublicensee to a Third Party that is not a Sublicensee for use in the development
of such Licensed Product (and not for resale) and transfers of industry standard quantities of Licensed Product for promotional
purposes shall not be deemed a sale of such Licensed Product that gives rise to Net Sales for purposes of this Section 1.26.

 

    	 	-5-	 

    CONFIDENTIAL

    

  

1.27         “Person”
means any person or entity, including any individual, trustee, corporation, partnership, trust, unincorporated organization, limited
liability company, business association, firm, joint venture or governmental agency or authority.

 

1.28         “Phase
1 Clinical Trial” means, as to a specific Licensed Product or Licensed Service, a study as described in 21 C.F.R.
§312.21(a) or a comparable clinical study in a country other than the United States.

 

1.29         “Phase
2 Clinical Trial” means, as to a specific Licensed Product or Licensed Service, a study in humans designed with the
principal purpose of determining initial efficacy and dosing of such Licensed Product in patients for the indication(s) being studied
as described in 21 C.F.R. §312.21(b); or a similar clinical study in a country other than the United States.

 

1.30         “Qualified
Financing” means the sale of capital stock of Licensee, in one or more transactions, that constitute a bona fide
equity financing at such time as the Net Proceeds to Licensee from third party investors that are not Affiliates of Licensee in
such equity financing(s) are less than or equal to the Qualified Financing Protection Ceiling; provided that if capital stock of
Licensee is sold in a single transaction or series of related transactions for different purchase prices and any of such shares
of capital stock are included for purposes of determining the number of shares of Qualifying Stock to be issued to COH pursuant
to Section 4.3, each share of capital stock that is sold for the lowest purchase price shall be deemed to be have sold first (regardless
of the date on which such shares are actually sold) and the next number of shares of capital stock that are sold for the next highest
purchase price shall be deemed to have sold next, et cetera, until the Net Proceeds from all such sales (applying all transaction
expenses to the first shares issued (except to the extent that such expenses are calculated on a per share basis, such as sales
commission, which shall be applied only to the shares included in such calculation) are equal to the Qualified Financing Protection
Ceiling.

 

1.31         “Qualified
Financing Protection Ceiling” means *.

 

1.32         “Qualified
Public Offering” means the first public offering of the Common Stock of Licensee to the general public that is effected
pursuant to a registration statement filed with, and declared effective by, the United States Securities and Exchange Commission
under the Act, as amended, but, for purposes of clarity shall not include an offering effected pursuant to a registration statement
on Form S-8 or any successor form.

 

1.33         “Qualifying
Stock” means the sum of: (i) the shares of Class A Common Stock issued and to be issued to COH in accordance with
Section 4.3, (ii) the number of shares of Common Stock (excluding (x) the shares referenced in the foregoing subclause (i) and
(y) shares issued to employees, directors and consultants in their capacity as such) of Licensee outstanding, and (iii) the maximum
number of shares of Common Stock of Licensee issuable (assuming the satisfaction of any conditions to exercisability, convertibility
or exchangeability) upon the exercise, conversion or exchange of all evidences of indebtedness, shares or other securities directly
or indirectly convertible into or exchangeable for Common Stock of the Licensee, including all rights, options or warrants to subscribe
for, purchase or otherwise acquire shares of Common Stock of the Licensee but excluding options and rights granted to employees,
directors and consultants in their capacity as such).

 

 

*Confidential material
redacted and filed separately with the Commission.

 

    	 	-6-	 

    CONFIDENTIAL

    

  

1.34         “Spacer
Patent Rights” means: (i) Patent Cooperation Treaty (PCT) application no. *; (ii) US patent application no. *; (iii)
patents, patent applications, continuation and divisional applications and foreign equivalents that claim the same invention(s)
and priority date as the foregoing; (iv) continuation-in-part applications that repeat a substantial portion of any of the foregoing
applications; (v) Letters Patent or the equivalent issued on any of the foregoing applications throughout the world; (vi) amendments,
extensions, renewals, reissues, and re-examinations of any of the foregoing; and (vii) any claim in a patent or patent application
licensed to Licensee by COH pursuant to an applicable license agreement that claims (a) a COH CAR, and (b) the spacer, hinge, or
linker sequence(s) that is used to connect the * of such COH CAR Covered by a Valid Claim of any of the foregoing (i)–(vii).
Notwithstanding the foregoing, “Spacer Patent Rights” shall only include any continuation-in-part application to the
extent that claims in such continuation-in-part application are supported in the specification of the parent application, unless
otherwise mutually agreed to in writing by the parties to this Agreement.

 

1.35         “Sublicensee”
means any Affiliate of Licensee or Third Party which enters into an agreement with Licensee involving the grant to such Affiliate
or Third Party of any rights under the license granted to Licensee pursuant to this Agreement.

 

1.36         “Sublicense
Revenues” means all consideration, in whatever form, due from a Sublicensee in return for the grant of a sublicense
of Licensee’s rights hereunder, excluding consideration in the form of: (i) royalties received by Licensee and calculated
wholly as a function of sales of Licensed Products or Licensed Services, (ii) payments or reimbursement for documented sponsored
research and/or development activities, valued at the actual direct cost of such activities on a fully burdened basis (including
reasonable margin for overhead), (iii) payment or reimbursement of reasonable patent expenses actually incurred or paid by Licensee
and not otherwise reimbursed, or payment of patent expenses required to by paid by Licensee hereunder, (iv) payments for the purchase
of equity in Licensee at the fair market value of such equity, and (v) payments recognized as Net Sales under this Agreement for
which a royalty is payable to COH. By way of clarification, the principal amount of any loan or other extension of credit provided
to Licensee or an Affiliate of Licensee in connection with the grant of a sublicense by Licensee that is other than an arm’s-length
credit relationship shall be deemed to constitute “Sublicense Revenues.”

 

1.37         “Territory”
means the entire world.

 

1.38         “Third
Party” means a Person that is neither a Party to this Agreement nor an Affiliate of a Party.

 

1.39         “Valid
Claim” means a claim of a pending patent application or an issued and unexpired patent included in the Spacer Patent
Rights in a particular jurisdiction, which claim has not, in such jurisdiction been finally rejected or been declared invalid or
cancelled by the patent office or a court of competent jurisdiction in a decision that is no longer subject to appeal as a matter
of right.

 

 

*Confidential material
redacted and filed separately with the Commission.

 

    	 	-7-	 

    CONFIDENTIAL

    

  

ARTICLE
2: DEVELOPMENT AND COMMERCIALIZATION EFFORTS

 

2.1           Development
and Commercialization Responsibilities. Licensee shall have the sole right and responsibility for, and control over, all
development, manufacturing and commercialization activities (including all regulatory activities) with respect to Licensed Products
and Licensed Services in the Field.

 

2.2           Licensee
Diligence. Licensee shall use Commercially Reasonable Efforts to develop and commercialize Licensed Products and Licensed
Services in the Field, directly or through one or more Sublicensees. Without limiting the foregoing, if Licensee, directly or through
one or Sublicensees, fails to accomplish any one of the “Diligence Milestones” set forth in this Section 2.2
by the date specified (each a “Deadline Date”) corresponding to such Diligence Milestone, COH shall have the
right, on notice to Licensee, to terminate this Agreement.

 

 

	“Deadline Date”	 	“Diligence Milestone”
	 	 	 
	1.  * (*) * from the Original Effective Date	 	Licensee to receive not less than $* through any combination of:  (i) Net Proceeds from the sale of any equity securities (or securities convertible into or exercisable for equity securities) and (ii) unrestricted grants or gifts.  
	 	 	 
	2.  * (*) * from the Original Effective Date	 	Licensee to * (with COH listed as principal institution for the clinical trial).  Licensee may extend this Deadline Date for up to * (*) additional * (*) month periods upon payment of $* to COH, for each * month (*) period.
	 	 	 
	3.  * (*) * from the Original Effective Date	 	Licensee to * (with COH listed as principal institution for the clinical trial).  Licensee may extend this Deadline Date for up to * (*) additional * (*) month periods upon payment of $* to COH for each * month (*) period.  If, however, this Diligence Milestone is not achieved after these * (*) extensions through no fault of Licensee, this Diligence Milestone will be additionally extended for as long as the Research Agreement is in effect.

 

 

*Confidential material redacted and filed separately with the
Commission.

 

    	 	-8-	 

    CONFIDENTIAL

    

  

2.3           Governance.
COH and Licensee shall each designate one individual to serve as the main point of contact for communications related to development
and commercialization of Licensed Products and Licensed Services under this Agreement (each a “Designated Representative”).
The initial Designated Representative of COH shall be George Megaw and the initial Designated Representative of Licensee shall
be Michael S. Weiss. Each Party may replace its Designated Representative at any time upon prior notice to the other Party. Licensee
shall keep COH reasonably informed as to progress in the development and commercialization of Licensed Products and Licensed Services.
Without limiting the foregoing, on or before January 15 and July 15 of each year during the term of this Agreement, Licensee shall
provide to COH a written report setting forth, in reasonable detail, its activities and achievements with respect to the development
and commercialization of Licensed Products and Licensed Services during the preceding six months (the “Semi-Annual Report”).
Each Semi-Annual Report shall also include the COH reference number, OTL 16-605. The Designated Representatives shall meet in person
twice each calendar year to present and discuss the current Semi-Annual Report at such location and date as mutually agreed. Each
Party shall be responsible for all expenses incurred by its Designated Representative in the participation in such annual meetings.
A copy of each Semi-Annual Report shall be provided, in addition to the persons set forth in Section 14.7, to: The Office of Technology
Licensing, email: licensing@coh.org.

 

ARTICLE
3: LICENSE GRANTS

 

3.1           Grant
of Rights. COH hereby grants to Licensee an exclusive royalty-bearing right and license under the Spacer Patent Rights
to make, have made, use, offer for sale, sell and import Licensed Products and to perform Licensed Services, in the Field, in the
Territory. The foregoing grant of rights shall be subject to: (i) the retained rights of the U.S. Government in the Spacer Patent
Rights pursuant to 35 U.S.C. §§ 200-212 and applicable U.S. government regulations, (ii) the royalty-free right of COH
and its Affiliates to practice the Spacer Patent Rights for educational and research uses, (iii) the right of COH and its Affiliates
to publicly disclose research results including, to the extent applicable, as specified in the Research Agreement, and (iv) the
right of COH and its Affiliates to allow other non-profit institutions to use the Spacer Patent Rights for the same purposes as
(ii) and (iii).

 

3.2           No
Implied Licenses. Licensee acknowledges that the licenses granted in this Agreement are limited to the scope expressly
granted and that, subject to the terms and conditions of this Agreement, all other rights under all Spacer Patent Rights and other
intellectual property rights Controlled by COH are expressly reserved to COH.

 

3.3           Sublicensing.
Licensee shall have the right to sublicense its rights hereunder without the consent of COH, effective on notice to COH. The terms
and conditions of each sublicense of Licensee’s rights hereunder shall be consistent with this Agreement. A true and complete
copy of each sublicense of Licensee’s rights hereunder, as well as any amendment thereto, shall be delivered to COH promptly
following the effective date of each such sublicense or amendment.

 

    	 	-9-	 

    CONFIDENTIAL

    

  

3.4           Effect
of Termination on Sublicenses.

 

(a)          In
the event that this Agreement terminates at any time for any reason, each sublicense validly granted hereunder which is in good
standing as of the effective date of such termination shall continue in effect as a direct license between COH (as licensor) and
Sublicensee (as licensee), provided that: (i) such sublicense, as determined by COH in its reasonable and good faith discretion,
contains or imposes on COH no material obligation or liability additional to those set forth in this Agreement, (ii) the Sublicensee
delivers to COH, within thirty (30) days of the effective date of the termination of this Agreement, written acknowledgement that
all payment and other obligations previously payable to Licensee under such sublicense shall thereafter be payable and due, and
be paid directly to COH, and (iii) such Sublicensee (including its employees and contractors) is not at such time debarred or excluded
or otherwise ineligible for participation in federally funded programs. All other sublicenses in existence as of the effective
date of the termination of this Agreement which fail to satisfy the foregoing conditions shall, upon such termination, terminate.

 

(b)          Further
and in addition to the requirements of Section 3.4(a), above, the conversion of a sublicense into a direct license between COH
(as licensor) and Sublicensee (as licensee) upon termination of this Agreement shall require that either [A] or [B] (but not both),
below, be satisfied:

 

[A]         On
the effective date of the termination of this Agreement:

 

(i)          the
Sublicensee is not a party to a proceeding in bankruptcy or insolvency filed by or against such Sublicensee, has not made a general
assignment for the benefit of its creditors, and is not in litigation with COH or any Affiliate of COH, and

 

(ii)         (1)
the effective royalty rate payable on Sublicensee’s Net Sales of Licensed Products and Licensed Services, (2) the aggregate
of other non- sale/royalty-based consideration due from Sublicensee, and (3) the other material terms and conditions of the sublicense
are materially no less favorable to COH than the corresponding terms (excluding the stock grant due pursuant to Section 4.3, below)
of this Agreement, or

 

[B] the terms
and conditions of the sublicense had been approved by COH prior to its having been entered into by Licensee and the Sublicensee,
such approval having been considered by COH expeditiously and not conditioned on the payment by Licensee of any additional consideration.

 

3.5           Documentation
of Licensed Services. Licensee and its Sublicensees shall provide Licensed Services only pursuant to one or more written
agreements which set forth, in reasonable detail, all consideration due to Licensee for the provision of such services. Licensee
shall provide a true and complete copy of each such agreement to COH promptly following the effective date of such agreement.

 

ARTICLE
4: PAYMENTS

 

4.1           Up-Front
Payment. The Parties acknowledge and agree that the non-refundable license fee of $* payable by Licensee within thirty
(30) days after the Original Effective Date pursuant to the Original Agreement has been paid by Licensee as of the A&R Effective
Date.

 

 

*Confidential material
redacted and filed separately with the Commission.

 

    	 	-10-	 

    CONFIDENTIAL

    

  

4.2          License
Maintenance Fee. On or before the tenth Business Day after the end of each License Year (excluding the first License Year
ending December 31, 2015), Licensee shall pay to COH a non-refundable license maintenance fee of $*. The license maintenance fee
paid in a given License Year shall be applied as credit against royalties otherwise due to COH pursuant to Section 4.8, below,
during the License Year in which payment was made but may not be carried over and applied as credit against royalties due in subsequent
years.

 

4.3          Stock
Grant.

 

(a)          Concurrently
with the execution of the Original Agreement, Licensee issued to COH stock certificates evidencing 333,333 validly issued, fully-paid,
non-assessable shares of Class A Common Stock. At the closing of each Qualified Financing that occurs prior to the achievement
of the Qualified Financing Protection Ceiling, Licensee will issue to COH and such reasonable number of designees as COH may specify
(provided that each such designee has: (i) demonstrated to the reasonable satisfaction of Licensee that it is an “accredited
investor” as such term is defined in Regulation D promulgated under the Securities Act of 1933 (the “Act”),
(ii) represented to Licensee that it is acquiring the shares for investment purposes only, and (iii) acknowledged that the shares
to be received are restricted securities under the Act (COH and its designees collectively, the “COH Stockholders”),
stock certificates evidencing a number of shares of validly issued, fully-paid, non-assessable shares of Class A Common Stock that
is determined such that upon the completion of such issuance, COH and its designees will hold 10% of the total number of shares
of Qualifying Stock, calculated as of immediately after the closing of such Qualified Financing (the “Measurement Date”).
Promptly after the applicable Measurement Date, Licensee will deliver to the COH Stockholders (i) certificates representing the
shares of Class A Common Stock to be issued in accordance with the foregoing, and (ii) a certificate, executed on behalf of Licensee
by an executive officer of Licensee, showing Licensee’s calculation of the number of shares of Qualifying Stock as of the
Measurement Date, the sales price of each share of capital stock issued in the Qualified Financings, and the gross proceeds and
Net Proceeds of the Qualified Financings and Licensee’s calculation of the shares of Class A Common Stock to be issued to
the COH Stockholders. Such shares of Class A Common Stock will be issued in consideration for the benefits provided to Licensee
under the Agreement and no additional consideration shall be payable for such shares of Class A Common Stock.

 

(c)          COH
and the other COH Stockholders acknowledge and agree that the COH Shares are restricted securities and will not be registered with
the Securities and Exchange Commission or qualified with any state securities authority and that, accordingly, the COH Shares may
not be distributed, sold or otherwise transferred except pursuant to an effective registration statement under the Act or pursuant
to an available exemption from the registration requirements of the Act.

 

4.4           First
Public Offering Fee. At the closing of the first Qualified Public Offering of stock of Licensee, Licensee shall pay COH
a one-time non-refundable fee of $*.

 

4.5           Sale
of Business. Upon any Change in Control of Licensee, Licensee shall pay COH a non-refundable fee of $*.

 

4.6           [Reserved]

 

 

*Confidential material
redacted and filed separately with the Commission.

 

    	 	-11-	 

    CONFIDENTIAL

    

  

4.7         Royalties.

 

(a)          Subject
to Section 4.8 below, Licensee shall pay to COH or its designee royalties in an amount equal to * percent of Net Sales of Licensed
Products and Licensed Services that do not include a COH CAR. Royalties shall be paid on a Licensed Product-by-Licensed Product,
Licensed Service-by-Licensed Service, and country-by-country basis until the expiration in each country of the last to expire of
the Valid Claims in such country Covering Licensed Products or Licensed Services.

 

(b)          Subject
to Section 4.8 below, Licensee shall pay to COH or its designee royalties in an amount equal to * percent of Net Sales of Licensed
Products and Licensed Services that include a COH CAR. Royalties shall be paid on a Licensed Product-by-Licensed Product, Licensed
Service-by-Licensed Service, and country-by-country basis until the expiration in each country of the last to expire of the Valid
Claims in such country Covering Licensed Products or Licensed Services.

 

4.8         Royalty
Offsets.

 

4.8.1           Third
Parties. If, in Licensee’s reasonable business judgment it is necessary to pay to a Third Party other than a Sublicensee
consideration (whether in the form of a royalty or otherwise) for the right to make, have made, use, sell, offer for sale or import
a Licensed Product or Licensed Service in a given jurisdiction, and if the aggregate royalty rates of any and all royalties payable
to such Third Party licensors when combined with the royalty rate payable to COH exceeds percent in the case of Net Sales of Licensed
Products or Licensed Services, then Licensee shall have the right with respect to any period for which royalties are due (i.e.,
a calendar quarter or calendar year) to set off percent of the aggregate royalties otherwise payable with respect to such period
and such jurisdiction to such Third Party licensors against royalties that would otherwise be due to COH hereunder with respect
to such period and jurisdiction; provided, however, that each Third Party licensor agrees to be stacked proportionally;
and provided further, however, that under no circumstances shall the royalty offsets permitted in this Section 4.8 result in the
reduction of the effective adjusted royalty rate and the royalty amount otherwise due to COH in any period for which payment is
due and in any jurisdiction pursuant to Section 4.7, above, by more than percent (e.g., minimum effective adjusted royalty
rate for Net Sales of Licensed Product or Licensed Services that do not include a COH CAR shall be percent).

 

4.8.2           A&R
IL13 License and A&R CD123 License. The Parties agree that, under certain circumstances and pursuant to the A&R IL13
License and the A&R CD123 License, the Licensee may set off the royalties due to COH by Licensee pursuant to Section 4.7(b)
of this Agreement against the royalties due to COH by Licensee pursuant to Section 4.8 of the A&R IL13 License or the A&R
CD123 License, as applicable.

 

 

*Confidential material
redacted and filed separately with the Commission.

 

    	 	-12-	 

    CONFIDENTIAL

    

  

4.9          Sublicense
Revenues.

 

4.9.1           Licensee
shall pay to COH an amount equal to percent of all Sublicense Revenues within thirty (30) days after payment is received from the
relevant Sublicensee. If Sublicense Revenues are not in cash or cash equivalents, the percentage share payable to COH pursuant
to this Section 4.9.1 shall be due, in COH’s sole discretion, either in kind or in its cash equivalent.

 

4.9.2           In
the event that Licensee sublicenses its rights hereunder solely for use by such sublicensee in connection with a CAR that is, as
of the Effective Date or as of the date of execution of such sublicense, a COH CAR, either directly or indirectly pursuant to an
applicable license or sublicense agreement (each, a “COH CAR License”), Licensee shall only be required to pay
to COH a percentage of sublicensing revenues pursuant to the applicable COH CAR License, if any, and shall not be required to make
additional payments pursuant to Section 4.9.1 of this Agreement; provided, that the sublicensee shall only receive
a license to use the rights granted hereunder in connection with the applicable COH CAR. COH will determine, for purposes of Licensee
invoicing, the allocation of sublicensing revenues among this Agreement and the applicable COH CAR Licenses at a time when a payment
pursuant to this Section 4.9.2 is due and shall inform Licensee in writing of the determination at such time.

 

4.10       
Timing of Royalty Payments. Royalty payments due under Section 4.8, above, shall be paid annually within sixty (60)
days following the end of each License Year until the first License Year in which aggregate Net Sales reach $*. Thereafter, all
royalty payments due under Section 4.8 shall be paid in quarterly installments, within sixty (60) days following the end of each
calendar quarter.

 

4.11       No
Deductions from Payments. Licensee is solely responsible for payment of any fee, royalty or other payment due to any Third
Party not a Sublicensee in connection with the research, development, manufacture, distribution, use, sale, import or export of
a Licensed Product or Licensed Service and, except as set forth in Section 4.8, above, Licensee shall not have the right to set
off any amounts paid to such a Third Party, including fee, royalty or other payment, against any amount payable to COH hereunder.

 

4.12       Single
Royalty. Only a single royalty payment shall be due and payable on Net Sales of a Licensed Product or performance of a
Licensed Service, regardless if such Licensed Product or Licensed Service is Covered by more than one Valid Claim.

 

ARTICLE
5: REPORTS, AUDITS AND FINANCIAL TERMS

 

5.1         Royalty
Reports. Within sixty (60) days after the end of each calendar quarter in which a royalty payment under Article 4 is required
to be made, Licensee shall send to COH a report of Net Sales of the Licensed Products and Licensed Services for which a royalty
is due, which report sets forth for such calendar quarter the following information, on a Licensed Product-by-Licensed Product,
Licensed Service-by-Licensed Service and country-by-country basis: (i) total Net Sales, (ii) total gross sales of Licensed Products
and Licensed Services, (iii) the quantity of each Licensed Products sold and Licensed Services performed, (iv) the exchange rate
used to convert Net Sales from the currency in which they are earned to United States dollars; and (v) the total royalty payments
due. All royalty reports shall also include the COH reference number, OTL 16-605. A copy of each royalty report shall be provided,
in addition to the persons set forth in Section 14.7, to: The Office of Technology Licensing, email: otl-royalties@coh.org.

 

 

*Confidential material
redacted and filed separately with the Commission.

 

    	 	-13-	 

    CONFIDENTIAL

    

  

5.2         Additional
Financial Terms.

 

5.2.1           Currency.
All payments to be made under this Agreement shall be made in United States dollars, unless expressly specified to the contrary
herein. Net Sales outside of the United States shall be first determined in the currency in which they are earned and shall then
be converted into an amount in United States dollars. All currency conversions shall use the conversion rate reported by Reuters,
Ltd. on the last Business Day of the calendar quarter for which such payment is being determined.

 

5.2.2           Payment
Method. Amounts due under this Agreement shall be paid in immediately available funds, by means of wire transfer to an
account identified by COH.

 

5.2.3           Withholding
of Taxes. Licensee may withhold from payments due to COH amounts for payment of any withholding tax that is required by
law to be paid to any taxing authority with respect to such payments. Licensee shall provide to COH all relevant documents and
correspondence, and shall also provide to COH any other cooperation or assistance on a reasonable basis as may be necessary to
enable COH to claim exemption from such withholding taxes and to receive a full refund of such withholding tax or claim a foreign
tax credit. Licensee shall give COH proper evidence from time to time as to the payment of such tax. The Parties shall cooperate
with each other in seeking deductions under federal and state tax laws and any double taxation or other similar treaty or agreement
from time to time in force.

 

5.2.4           Late
Payments. Any amounts not paid on or before the date due under this Agreement are subject to interest from the date due
through and including the date upon which payment is received. Interest is calculated, over the period between the date due and
the date paid, at a rate equal to * percentage point (*%) over the “bank prime loan” rate, as such rate is published
in the U.S. Federal Reserve Bulletin H.15 or successor thereto on the last Business Day of the applicable calendar quarter prior
to the date on which such payment is due.

 

5.2.5           Blocked
Currency. If, at any time, legal restrictions prevent the prompt remittance of part or all royalties with respect to any
country where a Licensed Product is sold or Licensed Service provided, payment shall be made through such lawful means or methods
as Licensee may determine. When in any country, the law or regulations prohibit both the transmittal and deposit of royalties or
other payments, Licensee shall continue to report all such amounts, but may suspend payment for as long as such prohibition is
in effect. As soon as such prohibition ceases to be in effect, all amounts that would have been obligated to be transmitted or
deposited but for the prohibition, together with accrued interested thereon, shall promptly be transmitted to COH.

 

5.3         Accounts
and Audit.

 

 

*Confidential material
redacted and filed separately with the Commission.

 

    	 	-14-	 

    CONFIDENTIAL

    

  

5.3.1           Records.
Licensee shall keep, and shall require that each Sublicensee keep, full, true and accurate books of account containing the particulars
of its Net Sales and the calculation of royalties. Licensee and its Sublicensees shall each keep such books of account and the
supporting data and other records at its principal place of business. Such books and records must be maintained available for examination
in accordance with this Section 5.3.1 for five calendar years after the end of the calendar year to which they pertain, and otherwise
as reasonably required to comply with GAAP.

 

5.3.2           Appointment
of Auditor. COH may appoint an internationally- recognized independent accounting firm reasonably acceptable to Licensee
to inspect the relevant books of account of Licensee and its Sublicensees to verify any reports or statements provided, or amounts
paid or invoiced (as appropriate), by Licensee or its Sublicensees.

 

5.3.3           Procedures
for Audit. COH may exercise its right to have Licensee’s and its Sublicensees’ relevant records examined only
during the five year period during which Licensee is required to maintain records, no more than once in any consecutive four calendar
quarters. Licensee and its Sublicensees are required to make records available for inspection only during regular business hours,
only at such place or places where such records are customarily kept, and only upon receipt of at least 15 days advance notice
from COH.

 

5.3.4           Audit
Report. The independent accountant will be instructed to provide to COH an audit report containing only its conclusions
and methodology regarding the audit, and specifying whether the amounts paid were correct and, if incorrect, the amount of any
underpayment or overpayment.

 

5.3.5           Underpayment
and Overpayment. After review of the auditor’s report: (i) if there is an uncontested underpayment by Licensee for
all of the periods covered by such auditor’s report, then Licensee shall pay to COH the full amount of that uncontested underpayment,
and (ii) if there is an uncontested overpayment for such periods, then COH shall provide to Licensee a credit against future payments
(such credit equal to the full amount of that overpayment), or, if Licensee is not obligated to make any future payments, then
COH shall pay to Licensee the full amount of that overpayment. Contested amounts are subject to dispute resolution under Article
12. If the total amount of any such underpayment (as agreed to by Licensee or as determined under Article 12) exceeds * percent
of the amount previously paid by Licensee for the period subject to audit, then Licensee shall pay the reasonable costs for the
audit. Otherwise, all costs of the audit shall be paid by COH.

 

 

*Confidential material
redacted and filed separately with the Commission.

 

    	 	-15-	 

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ARTICLE
6: LICENSEE COVENANTS

 

6.1         Licensee
covenants and agrees that:

 

(a)          During
the period commencing on the Original Effective Date and ending on the third (3rd) anniversary of the Original Effective
Date, both Dr. Lindsay A. Rosenwald and Michael S. Weiss will hold senior management positions of Licensee; provided, that, in
the event of a Change of Control of Licensee, subsequent to such Change of Control, in the event that either Dr. Lindsay A. Rosenwald
or Michael S. Weiss no longer holds a senior management position of Licensee both individuals must remain materially involved with
the oversight and management of the development of Licensed Products during such period; provided further that in the event of
the death of either of Dr. Rosenwald or Mr. Weiss, Licensee will be excused from observing this Section 6.1(a) with regard to the
decedent;

 

(b)          the
Charter provides, and any amendment thereto will provide the holders of Class A Shares with the right to nominate one individual
to the board of directors of Licensee for a period of ten years after the formation of Licensee;

 

(c)          in
conducting activities contemplated under this Agreement, it shall comply in all material respects with all applicable laws and
regulations including, without limitation, those related to the manufacture, use, labeling importation and marketing of Licensed
Products and Licensed Services; and

 

(d)          Licensee
had obtained and after the date hereof will obtain all authorizations necessary for the issuance of the COH Shares and the Common
Stock issuable to COH upon conversion of the COH Shares issuable pursuant to this Agreement and/or the Charter prior to the issuance
of such COH Shares and in any event prior to the issuance of any Qualifying Stock or the consummation of a Change of Control and
covenants that all such shares issued on or prior to the date hereof are, and those issued after the date hereof will be, validly
issued, fully paid and non-assignable and free of restrictions on transfer, other than restrictions on transfer under state and
federal securities laws.

 

ARTICLE
7: INTELLECTUAL PROPERTY; PATENT PROSECUTION, MAINTENANCE AND ENFORCEMENT.

 

7.1         Patent
Prosecution, Maintenance and Enforcement.

 

(a)          COH
shall be responsible for the preparation, filing, prosecution, and maintenance of all Spacer Patent Rights, using counsel of its
choice. COH will timely provide Licensee with copies of all relevant documentation relating to such prosecution and Licensee shall
keep such information confidential. In addition, COH shall instruct the patent counsel prosecuting Spacer Patent Rights to (i)
copy Licensee on patent prosecution documents that are received from or filed with the United States Patent and Trademark Office
and foreign equivalent, as applicable; (ii) if requested by Licensee, provide Licensee with copies of draft submissions to the
USPTO prior to filing; and (iii) give reasonable consideration to the comments and requests of Licensee or its patent counsel,
provided that (a) COH reserves the sole right to make all final decisions with respect to the preparation, filing, prosecution
and maintenance of such patent applications and patents; and (b) the patent counsel remains counsel to COH (and shall not jointly
represent Licensee unless requested by Licensee and approved by COH, and an appropriate engagement letter and conflict waiver are
in effect). All patents and patent applications in Spacer Patent Rights, to the extent assignable in whole or in part to COH, shall
be assigned to COH.

 

    	 	-16-	 

    CONFIDENTIAL

    

  

(b)          COH
will not unreasonably refuse to amend any patent application in Spacer Patent Rights to include claims reasonably requested by
Licensee to protect the products contemplated to be sold by Licensee under this Agreement. If Licensee informs COH of other countries
or jurisdictions in which it wishes to obtain patent protection with respect to the Spacer Patent Rights, COH shall prepare, file,
prosecute and maintain patent applications in such counties and any patents resulting therefrom (and, for the avoidance of doubt,
such patent applications and patents shall be deemed included in the Spacer Patent Rights). On a country by country and patent
by patent basis, Licensee may elect to surrender any patent or patent application in Spacer Patent Rights in any country upon sixty
(60) days advance written notice to COH. Such notice shall relieve Licensee from the obligation to pay for future patent costs
but shall not relieve Licensee from responsibility to pay patent costs incurred prior to the expiration of the sixty (60) day notice
period. Such U.S. or foreign patent application or patent shall thereupon cease to be a Spacer Patent Right hereunder, Licensee
shall have no further rights therein and COH shall be free to license its rights to that particular U.S. or foreign patent application
or patent to any other party on any terms.

 

(c)          Each
Party shall promptly provide written notice to the other in the event it becomes aware of any actual or probable infringement of
any of the Spacer Patent Rights in or relevant to the Field or of any Third Party claim regarding the enforceability or validity
of any Spacer Patent Rights (“Infringement Notice”). Licensee shall, in cooperation with COH, use reasonable
efforts to terminate infringement without litigation.

 

(d)          If
infringing activity has not been abated within ninety (90) days following the date the Infringement Notice takes effect, then Licensee
may, following consultation with COH, in its sole discretion and at its sole expense, take action against any alleged infringer
or in defense of such any claim, provided, that Licensee has exclusive rights under this Agreement. Any recovery
obtained by Licensee as the result of legal proceedings initiated and paid for by Licensee pursuant to this subsection (d), after
deduction of Licensee’s reasonable out-of-pocket expenses incurred in securing such recovery, shall be deemed to be Net Sales
of Licensed Products and/or Licensed Services in the calendar quarter in which such recovery was received and royalties shall be
due and payable thereon accordingly.

 

(e)          If
COH is involuntarily joined in a suit initiated by Licensee, then the Licensee will pay any costs incurred by COH arising out of
such suit, including but not limited to, reasonable legal fees of counsel that COH selects and retains to represent it in the suit.

 

(f)          In
the event that Licensee declines either to cause such infringement to cease (e.g., by settlement or injunction) or to initiate
and thereafter diligently maintain legal proceedings against the infringer other than as part of a mutually agreed upon bona fide
strategy, developed with the guidance of outside patent counsel, to preserve the Spacer Patent Rights, COH may, in its sole discretion
and at its sole expense, take action against such alleged infringer or in defense of any such Third Party claim. Any recovery obtained
by COH as the result of any such legal proceedings shall be for the benefit of COH only.

 

7.2         Trademarks.
Licensee shall be responsible for the selection, registration, maintenance, and defense of all trademarks for use in connection
with the sale or marketing of Licensed Products and Licensed Services in the Field in the Territory (the “Marks”),
as well as all expenses associated therewith. All uses of the Marks by Licensee or a Sublicensee shall comply in all material respects
with all applicable laws and regulations (including those laws and regulations particularly applying to the proper use and designation
of trademarks in the applicable countries). Licensee shall not, without COH’s prior written consent, use any trademarks or
house marks of COH (including the COH corporate name), or marks confusingly similar thereto, in connection with Licensee commercialization
of Licensed Products or Licensed Services under this Agreement in any promotional materials or applications or in any manner implying
an endorsement by COH of Licensee or the Licensed Products or Licensed Services. Licensee shall own all Marks.

 

    	 	-17-	 

    CONFIDENTIAL

    

  

7.3         Challenge
to the Spacer Patent Rights by Licensee.

 

(a)          COH
may terminate this Agreement and, notwithstanding Section 3.3, above, all Sublicenses issued hereunder, upon written notice to
Licensee in the event that Licensee or any of its Affiliates or Sublicensees directly or indirectly asserts a Patent Challenge.
“Patent Challenge” means any challenge in a legal or administrative proceeding to the patentability, validity
or enforceability of any of the Spacer Patent Rights (or any claim thereof), including by: (a) filing or pursuing a declaratory
judgment action in which any of the Spacer Patent Rights is alleged to be invalid or unenforceable; (b) citing prior art against
any of the Spacer Patent Rights, filing a request for or pursuing a re-examination of any of the Spacer Patent Rights (other than
with COH’s written agreement), or becoming a party to or pursuing an interference; or (c) filing or pursuing any re-examination,
opposition, cancellation, nullity or other like proceedings against any of the Spacer Patent Rights; but excluding any challenge
raised as a defense against a claim, action or proceeding asserted by COH against Licensee, its Affiliates or Sublicensees. In
lieu of exercising its rights to terminate under this Section 7.3(a) COH may elect upon written notice to increase the payments
due under all of Section 4 by * percent (*%), which election will be effective retroactively to the date of the commencement of
the Patent Challenge. Licensee acknowledges and agrees that this Section 7.3(a) is reasonable, valid and necessary for the adequate
protection of COH’s interest in and to the Spacer Patent Rights, and that would not have granted to Licensee the licenses
under those Spacer Patent Rights, without this Section.

 

(b)          Payment
of COH Patent Expenses. The Parties acknowledge that, prior to the Original Effective Date, COH provided to Licensee documentation
of historic expenses incurred by COH with respect to the drafting, prosecution and maintenance of the Spacer Patent Rights. In
consideration of such historic expenditures by COH, the Parties acknowledge and agree that Licensee has reimbursed COH for such
expenses within thirty (30) days of the Original Effective Date.

 

(c)          After
the Original Effective Date, COH shall provide to Licensee an annual invoice and reasonably detailed documentation with
respect to COH’s out-of-pocket expenses incurred with respect to such prosecution and maintenance for the previous
year. Licensee shall reimburse COH for * percent of such expenses within thirty (30) days after receipt of such invoice and
documentation.

 

7.4           Marking.
Licensee and its Sublicensees shall mark all Licensed Products and all materials related to Licensed Services in such a matter
as to conform with the patent laws of the country to which such Licensed Products are shipped or in which such products are sold
and such Licensed Services performed.

 

 

*Confidential material redacted
and filed separately with the Commission.

 

    	 	-18-	 

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ARTICLE
8: TERM AND TERMINATION

 

8.1         Term
and Expiration of Term. The term of this Agreement (the “Term”) shall commence on the A&R Effective
Date and, notwithstanding any other provision of this Agreement, unless sooner terminated by mutual agreement or pursuant to any
other provision of this Agreement, this Agreement shall expire on a country-by-country basis and on a Spacer Patent Right-by- Spacer
Patent Right basis on the later to occur of: (a) the expiration of the last to expire of any of the Spacer Patent Rights in such
country (or if no patent issues, until the last patent application in Spacer Patent Rights is abandoned), and (b) the date on which
the last of the remaining obligations under this Agreement between the Parties with respect to the payment of royalties with respect
to Licensed Products and Licensed Services have been satisfied (such expiry of the Term hereinafter referred to as “Expiration”).

 

8.2         Termination.

 

8.2.1           Material
Breach. Either Party may terminate this Agreement prior to its Expiration for any material breach by the other Party, provided,
that, the Party seeking to terminate shall have first given the breaching Party notice of such material breach with reasonable
particulars of the material breach, and the Party receiving the notice of the material breach shall have failed to cure that material
breach within thirty (30) days after the date of receipt of such notice.

 

8.2.2           Bankruptcy.
COH shall have the right to terminate this Agreement prior to its Expiration upon notice to Licensee, in the event that: (i) Licensee
seeks protection of any bankruptcy or insolvency law other than with the prior consent of City of Hope, or (ii) a proceeding in
bankruptcy or insolvency is filed by or against Licensee and not withdrawn, removed or vacated within 120 days of such filing,
or there is adjudication by a court of competent jurisdiction that Licensee is bankrupt or insolvent.

 

8.2.3           Termination
at Will by Licensee. Licensee shall have the right to terminate this Agreement prior to its Expiration upon notice to COH
without cause, effective no fewer than 90 days following the date of such notice.

 

8.3         Effect
of Termination.

 

8.3.1           Upon
any termination of this Agreement pursuant to Section 8.2 (but for clarity, not in the case of its Expiration), all rights and
licenses granted to Licensee under Article 4, if any, shall immediately terminate on and as of the effective date of termination
as provided in Section 8.2, except that Licensee shall have the right to continue to sell Licensed Products manufactured prior
to the effective date of such termination until the sooner of: (i) ninety (90) days after the effective date of termination, or
(ii) the exhaustion of Licensee’s inventory of Licensed Products.

 

8.3.2           Upon
termination of this Agreement pursuant to Section 8.2 (but for clarity, not in the case of its Expiration):

 

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(a)          Each
Party shall promptly return to the other Party all relevant records and materials in its possession or control containing or comprising
the other Party’s Confidential Information and to which the Party does not retain rights hereunder.

 

(b)          Licensee
shall discontinue making any representation regarding its status as a licensee of COH for Licensed Products and Licensed Services.
Subject to Section 8.3.1, above, Licensee shall cease conducting any activities with respect to the marketing, promotion, sale
or distribution of Licensed Products and Licensed Services.

 

8.3.3           Termination
of this Agreement through any means and for any reason pursuant to Section 8.2 (but for clarity, not in the case of its Expiration),
shall not relieve the Parties of any obligation accruing prior thereto, including the payment of all sums due and payable, and
shall be without prejudice to the rights and remedies of either Party with respect to any antecedent breach of any of the provisions
of this Agreement.

 

8.4         Survival.
Sections 4.11, 5.1, 5.2, 5.3, 7.4, 8.3, 8.4, Article 10, Article 11, Article 12, Sections 14.2, 14.4, 14.7, and 14.10 shall survive
termination of this Agreement for any reason pursuant to Section 8.2 and Expiration pursuant to Section 8.1.

 

ARTICLE
9: REPRESENTATIONS AND WARRANTIES

 

9.1         Mutual
Representations and Warranties. COH and Licensee each represents and warrants as follows:

 

9.1.1           It
has the right and authority to enter into this Agreement and all action required to be taken on its behalf, its officers, directors,
partners and stockholders necessary for the authorization, execution, and delivery of this Agreement and, the performance of all
of its obligations hereunder, and this Agreement, when executed and delivered, will constitute valid and legally binding obligations
of such Party, enforceable in accordance with its terms, subject to: (i) laws limiting the availability of specific performance,
injunctive relief, and other equitable remedies; and (ii) bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance
or other similar laws now or hereafter in effect generally relating to or affecting creditors’ rights generally;

 

9.1.2           Entry
into this Agreement will not constitute a breach of any other agreement to which it is party;

 

9.1.3           It
has read this Agreement, with assistance from its counsel of choice. It understands all of this Agreement’s terms. It has
been given a reasonable amount of time to consider the contents of this Agreement before each Party executed it. It agrees that
it is executing this Agreement voluntarily with full knowledge of this Agreement’s legal significance; and

 

9.1.4           It
has made such investigation of all matters pertaining to this Agreement that it deems necessary, and does not rely on any statement,
promise, or representation, whether oral or written, with respect to such matters other than those expressly set forth herein.
It agrees that it is not relying in any manner on any statement, promise, representation or understanding, whether oral, written
or implied, made by any Party, not specifically set forth in this Agreement. It acknowledges that, after execution of this Agreement,
it may discover facts different from or in addition to those which it now knows or believes to be true. Nevertheless, it agrees
that this Agreement shall be and remain in full force and effect in all respects, notwithstanding such different or additional
facts.

 

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9.2         Representations
and Warranties of COH. COH represents and warrants that, as of the Original Effective Date, to the actual knowledge of
the Investigator (as defined in the Research Agreement) and the Director of its Office of Technology Transfer without independent
inquiry, COH has the full power and authority to grant the rights, licenses and privileges granted herein.

 

9.3         Representations
and Warranties of Licensee. Licensee represents and warrants as of the Original Effective Date (except as specifically
provided below) and as of the A&R Effective Date (except as specifically provided below):

 

9.3.1           all
authorizations necessary for the issuance of the COH Shares and the Common Stock issuable to COH upon conversion of the COH have
been obtained;

 

9.3.2           no
consent, approval, order, or authorization of, or registration, qualification, designation, declaration, or filing with, any federal,
state, or local governmental authority on the part of Licensee was required in connection with the offer, sale, or issuance of
the COH Shares (and the Common Stock issuable upon conversion of the COH Shares) or the consummation of any other transaction contemplated
hereby, except for the following: (i) the filing of a notice of exemption pursuant to Section 25102(f) of the California Corporate
Securities Law of 1968, as amended, which was filed by Licensee promptly following the Original Effective Date and promptly following
any Measurement Date; and (ii) the compliance with other applicable state securities laws, which compliance has occurred or will
occur within the appropriate time periods therefor. The offer, sale, and issuance of the COH Shares are exempt from the registration
requirements of Section 5 of the Act, and from the qualification requirements of Section 25110 of the California Securities Law,
and neither Licensee, nor any authorized agent acting on its behalf has taken or will take any action hereafter that results in
the loss of such exemptions;

 

9.3.3           The
sale of the COH Shares was not, and the subsequent conversion of the COH Shares into Common Stock will not be , subject to any
preemptive rights or rights of first refusal that have not been properly waived or complied with;

 

9.3.4           The
COH Shares, when issued, sold and delivered in accordance with the terms of the Original Agreement or this Agreement for the consideration
expressed therein, were and will be duly and validly issued, fully paid and nonassessable and free of restrictions on transfer,
other than restrictions on transfer under applicable state and federal securities laws. The Common Stock issuable upon conversion
of the COH Shares has been duly and validly reserved for issuance and, upon issuance in accordance with the terms of the Charter,
will be duly and validly issued, fully paid and nonassessable and free of restrictions on transfer other than restrictions on transfer
under applicable state and federal securities laws.

 

    	 	-21-	 

    CONFIDENTIAL

    

  

9.3.5           As
of the A&R Effective Date, the authorized capital stock of Licensee consists of (i) 50,000,000 shares of Common Stock (24,209,0251
of which shall be issued and outstanding after giving effect to the issuances contemplated hereunder); of which 1,000,000 shares
were designated as Class A Common Stock (1,000,000 of which are issued and outstanding (taking into account the issuance of the
COH Shares of Class A Common Stock pursuant to the Original Agreement)), and (ii) 2,000,000 shares of preferred stock, 250,000
of which are designated as Series A Preferred Stock (250,000 of which are issued and outstanding). As of the A&R Effective
Date there are outstanding warrants exercisable for 4,239,396 shares of Common Stock at an exercise price of $8.50 per share and
138,462 shares of Common Stock at an exercise price of $0.0001. As of the A&R Effective Date, Licensee has also reserved but
has not issued an aggregate of 2,000,000 shares of Common Stock for issuance to employees, directors and consultants pursuant to
Licensee’s equity incentive compensation plans. As of the A&R Effective Date, all issued and outstanding shares were
duly authorized and validly issued and were fully paid and nonassessable. Other than as provided in this Section 9.3.5, or pursuant
to litigation as described in the Company’s filings with the Securities and Exchange Commission prior to the date hereof,
there are no other outstanding rights, options, warrants, preemptive rights, rights of first refusal, or similar rights for the
purchase or acquisition from Licensee of any securities of Licensee nor any commitments to issue or execute any such rights, options,
warrants, preemptive rights or rights of first refusal. The respective rights, preferences, privileges, and restrictions of the
Common Stock, including the Class A Common Stock and the preferred stock are solely as stated in the Charter. As of the Original
Effective Date, the COH Shares represented a 10% interest in the capital stock of Licensee; and

 

9.3.6           Licensee
is not in violation or default of any provision of the Charter or its bylaws.

 

9.4         Exclusions.
Nothing in this Agreement is or shall be construed as:

 

9.4.1           A
warranty or representation by COH as to the validity or scope of any claim or patent or patent application within the Spacer Patent
Rights;

 

9.4.2           A
warranty or representation by COH that anything made, used, sold, or otherwise disposed of under any license granted in this Agreement
is or will be free from infringement of any patent rights or other intellectual property right of any Third Party;

 

9.4.3           A
grant by COH, whether by implication, estoppel, or otherwise, of any licenses or rights under any patents other than Spacer Patent
Rights as defined herein, regardless of whether such patents are dominant or subordinate to Spacer Patent Rights;

 

9.4.4           An
obligation on COH to bring or prosecute any suit or action against a third party for infringement of any of the Spacer Patent Rights;

 

9.4.5           An
obligation to furnish any know-how not provided in Spacer Patent Rights; or

 

9.4.6           A
representation or warranty of the ownership of the Spacer Patent Rights other than as set forth in Section 9.2, above.

 

 

1 To be confirmed by Mustang

 

    	 	-22-	 

    CONFIDENTIAL

    

  

9.5           DISCLAIMER.
NO WARRANTY IS GIVEN WITH RESPECT TO THE SPACER PATENT RIGHTS, EXPRESS OR IMPLIED, EITHER IN FACT OR BY OPERATION OF LAW, BY
STATUTE OR OTHERWISE, AND THE PARTIES SPECIFICALLY DISCLAIM ANY EXPRESS OR IMPLIED WARRANTY OF MERCHANTABILITY, FITNESS FOR A PARTICULAR
PURPOSE, VALIDITY OF THE SPACER PATENT RIGHTS OR NON-INFRINGEMENT OF THE INTELLECTUAL PROPERTY OR OTHER RIGHTS OF ANY THIRD PARTY.
THE WARRANTIES SET FORTH IN SECTIONS 9.1 AND 9.2, ABOVE, ARE IN LIEU OF ALL OTHER WARRANTIES, EXPRESS OR IMPLIED, INCLUDING BUT
NOT LIMITED TO, THE IMPLIED WARRANTIES OF MERCHANTABILITY OR FITNESS FOR A PARTICULAR PURPOSE, VALIDITY, NON-INFRINGEMENT AND ALL
SUCH OTHER WARRANTIES ARE HEREBY EXPRESSLY DISCLAIMED.

 

ARTICLE
10: INDEMNIFICATION

 

10.1         Indemnification
by Licensee. Licensee shall defend, indemnify and hold harmless COH, its Affiliates, officers, directors, shareholders,
employees and agents (“COH Indemnitees”) from and against any and all Third Party liabilities, claims, suits,
and expenses, including reasonable attorneys’ fees (collectively, “Losses”), arising out of or are in
any way attributable to: (i) the material breach of any representation or warranty made by Licensee under this Agreement, (ii)
the research, development, marketing, approval, manufacture, packaging, labeling, handling, storage, transportation, use, distribution,
promotion, marketing or sale of Licensed Products or Licensed Services by or on behalf of Licensee, any of its Affiliates or a
Sublicensee or any other exercise of rights under this Agreement or pursuant to any sublicense, or (iii) the negligence, willful
misconduct or failure to comply with applicable law by a Licensee Indemnitee or Sublicensee; in each case except to the extent
that such Losses are caused directly by: (a) COH’s material breach of any representation or warranty made by COH under this
Agreement, (b) COH’s material breach of its obligations under this Agreement, and/or (c) the gross negligence or willful
misconduct of a COH Indemnitee.

 

10.2         Indemnification
by COH. COH shall defend, indemnify and hold harmless Licensee and its Affiliates and their respective officers, directors,
shareholders, employees and agents (collectively, the “Licensee Indemnitees”) from and against any and all Losses
caused directly by: (i) the material breach of any representation or warranty made by COH under this Agreement, or (ii) the gross
negligence or willful misconduct of a COH Indemnitee, except to the extent that such Losses arise out of or are in any way attributable
to: (a) the material breach of any representation or warranty made by Licensee under this Agreement, (b) the research, development,
marketing, approval, manufacture, packaging, labeling, handling, storage, transportation, use, distribution, promotion, marketing
or sale of Licensed Products or Licensed Services by or on behalf of Licensee or a Sublicensee, or (c) the negligence, willful
misconduct or failure to comply with applicable law by a Licensee Indemnitee or a Sublicensee.

 

10.3         Procedure.
The indemnities set forth in this Article 10 are subject to the condition that the Party seeking the indemnity shall forthwith
notify the indemnifying Party on being notified or otherwise made aware of a liability, claim, suit, action or expense and that
the indemnifying Party defend and control any proceedings with the other Party being permitted to participate at its own expense
(unless there shall be a conflict of interest which would prevent representation by joint counsel, in which event the indemnifying
Party shall pay for the other Party’s counsel); provided, that, the indemnifying Party may not settle the liability,
claim, suit, action or expense, or otherwise admit fault of the other Party or consent to any judgment, without the written consent
of the other Party (such consent not to be unreasonably withheld). Notwithstanding the foregoing, no delay in the notification
of the existence of any claim of Loss shall cause a failure to comply with this Section 10.3 as long as such delay shall not have
materially impaired the rights of the indemnifying Party.

 

    	 	-23-	 

    CONFIDENTIAL

    

  

10.4       Insurance.

 

(a)          Within
thirty (30) days following the Effective Date, Licensee shall procure at its sole expense and provide to COH evidence of comprehensive
or commercial general liability insurance (contractual liability included) with limits of at least: (i) each occurrence, $*; (ii)
products/completed operations aggregate, $*; (iii) personal and advertising injury, $*; and general aggregate (commercial form
only), $*.

 

(b)          The
foregoing policies will provide primary coverage to COH and shall name the COH Indemnitees as additional insureds, and shall remain
in effect during the term of this Agreement and for * years following the termination or expiration of the term of this Agreement.
The COH Indemnitees shall be notified in writing by Licensee not less than thirty (30) days prior to any modification, cancellation
or non-renewal of such policy. Licensee’s insurance must include a provision that the coverages will be primary and will
not participate with nor will be excess over any valid and collective insurance or program of self-insurance carried or maintained
by the COH Indemnitees. Such insurance coverage shall be maintained with an insurance company or companies having an A.M. Best’s
rating (or its equivalent) of A-XII or better.

 

(c)          Licensee
expressly understands that the coverage limits in Section 10.4(a) do not in any way limit the Licensee’s liability.

 

10.5         LIMITATION
ON DAMAGES. NOTWITHSTANDING ANYTHING CONTAINED IN THIS AGREEMENT TO THE CONTRARY, EXCEPT IN RELATION TO LICENSEE’S
INDEMNIFICATION OBLIGATIONS UNDER SECTION 10.1 AND ANY BREACH BY LICENSEE OF ARTICLE 11: (I) IN NO EVENT SHALL EITHER PARTY BE
LIABLE FOR ANY SPECIAL, PUNITIVE, CONSEQUENTIAL, INDIRECT, OR INCIDENTAL DAMAGES (INCLUDING LOSS OF PROFITS, COSTS OF PROCURING
SUBSTITUTE GOODS, LOST BUSINESS OR ENHANCED DAMAGES FOR INTELLECTUAL PROPERTY INFRINGEMENT) WHETHER BASED UPON BREACH OF WARRANTY,
BREACH OF CONTRACT, NEGLIGENCE, STRICT LIABILITY IN TORT OR ANY OTHER LEGAL THEORY, AND (II) IN NO EVENT SHALL COH BE LIABLE TO
LICENSEE FOR AN AGGREGATE AMOUNT IN EXCESS OF TWO-THIRDS OF THE TOTAL CONSIDERATION PAID TO COH HEREUNDER. 

 

 

*Confidential material
redacted and filed separately with the Commission.

 

    	 	-24-	 

    CONFIDENTIAL

    

  

ARTICLE
11: CONFIDENTIALITY

 

11.1       Confidential
Information. During the term of this Agreement and for * (*) years thereafter without regard to the means of termination:
(i) COH shall not use, for any purpose other than the purpose contemplated by this Agreement, or reveal or disclose to any Third
Party Licensee Confidential Information; and (ii) Licensee shall not use, for any purpose other than the purpose contemplated by
this Agreement, or reveal or disclose COH Confidential Information to any Third Party. The Parties shall take reasonable measures
to assure that no unauthorized use or disclosure is made by others to whom access to such information is granted.

 

11.2       Exceptions. Notwithstanding
the foregoing, a Party may use and disclose Confidential Information of the other Party as follows:

 

(a)          if
required by applicable law, rule, regulation, government requirement and/or court order, provided, that, the disclosing
Party promptly notifies the other Party of its notice of any such requirement and provides the other Party a reasonable opportunity
to seek a protective order or other appropriate remedy and/or to waive compliance with the provisions of this Agreement;

 

(b)          to
the extent such use and disclosure occurs in the filing or publication of any patent application or patent on inventions;

 

(c)          as
necessary or desirable for securing any regulatory approvals, including pricing approvals, for any Licensed Products or Licensed
Services, provided, that, the disclosing Party shall take all reasonable steps to limit disclosure of the Confidential
Information outside such regulatory agency and to otherwise maintain the confidentiality of the Confidential Information;

 

(d)          to
take any lawful action that it deems necessary to protect its interest under, or to enforce compliance with the terms and conditions
of, this Agreement;

 

(e)          to
the extent necessary, to its Affiliates, directors, officers, employees, consultants, vendors and clinicians under written agreements
of confidentiality at least as restrictive as those set forth in this Agreement, who have a need to know such information in connection
with such Party performing its obligations or exercising its rights under this Agreement; and

 

(f)          by
Licensee, to actual and potential investors, licensees, Sublicensees, consultants, vendors and suppliers, and academic and commercial
collaborators, under written agreements of confidentiality at least as restrictive as those set forth in this Agreement.

 

11.3       Certain
Obligations. During the Term and for a period of * (*) years thereafter and subject to the exceptions set forth in Section
11.2, Licensee, with respect to COH Confidential Information, and COH, with respect to Licensee Confidential Information, agree:

 

 

*Confidential material
redacted and filed separately with the Commission.

 

    	 	-25-	 

    CONFIDENTIAL

    

  

(a)          to
use such Confidential Information only for the purposes contemplated under this Agreement,

 

(b)          to
treat such Confidential Information as it would its own proprietary information which in no event shall be less than a reasonable
standard of care,

 

(c)          to
take reasonable precautions to prevent the disclosure of such Confidential Information to a Third Party without written consent
of the other Party, and

 

(d)          to
only disclose such Confidential Information to those employees, agents and Third Parties who have a need to know such Confidential
Information for the purposes set forth herein and who are subject to obligations of confidentiality no less restrictive than those
set forth herein.

 

11.4       Termination.
Upon termination of this Agreement pursuant to Section 8.2 (but for clarity, not in the case of its Expiration), and upon the request
of the disclosing Party, the receiving Party shall promptly return to the disclosing Party or destroy all copies of Confidential
Information received from such Party, and shall return or destroy, and document the destruction of, all summaries, abstracts, extracts,
or other documents which contain any Confidential Information of the other Party in any form, except that each Party shall be permitted
to retain a copy (or copies, as necessary) of such Confidential Information for archival purposes or to enforce or verify compliance
with this Agreement, or as required by any applicable law or regulation.

 

ARTICLE
12: DISPUTE RESOLUTION

 

All Disputes shall be first referred to
a Vice President, Center for Applied Technology Development of COH (the “COH VP”) and the President of Licensee
for resolution, prior to proceeding under the other provisions of this Article 12. A Dispute shall be referred to such executives
upon one Party (the “Initiating Party”) providing the other Party (the “Responding Party”)
with notice that such Dispute exists, together with a written statement describing the Dispute with reasonable specificity and
proposing a resolution to such Dispute that the Initiating Party is willing to accept, if any. Within ten days after having received
such statement and proposed resolution, if any, the Responding Party shall respond with a written statement that provides additional
information, if any, regarding such Dispute, and proposes a resolution to such Dispute that the Responding Party is willing to
accept, if any. In the event that such Dispute is not resolved within 60 days after the Responding Party’s receipt of the
Initiating Party’s notice, either Party may bring and thereafter maintain suit against the other with respect to such Dispute;
provided, however, that the exclusive jurisdiction of any such suit shall be the state and federal courts located in Los Angeles
County, California, and the Parties hereby consent to the exclusive jurisdiction and venue of such courts.

 

ARTICLE
13: GOVERNMENTAL MATTERS

 

13.1       Governmental
Approval or Registration. If this Agreement or any associated transaction is required by the law of any nation to be either
approved or registered with any governmental agency, Licensee shall assume all legal obligations to do so. Licensee shall notify
COH if it becomes aware that this Agreement is subject to a U.S. or foreign government reporting or approval requirement. Licensee
shall make all necessary filings and pay all costs including fees, penalties and all other out-of-pocket costs associated with
such reporting or approval process.

 

    	 	-26-	 

    CONFIDENTIAL

    

  

13.2         Export
Control Laws. Licensee shall observe all applicable U.S. and foreign laws with respect to the transfer of Licensed Products
and related technical data to foreign countries, including, without limitation, the International Traffic in Arms Regulations and
the Export Administration Regulations.

 

13.3         Preference
for United States Industry. If Licensee sells a Licensed Product in the U.S., Licensee shall manufacture said product substantially
in the U.S.

 

ARTICLE
14: MISCELLANEOUS

 

14.1         Assignment
and Delegation. Except as expressly provided in this Section 14.1, neither this Agreement nor any right or obligation hereunder
shall be assignable in whole or in part, whether by operation of law, or otherwise by Licensee without the prior written consent
of COH. Notwithstanding the foregoing, Licensee may assign or transfer its rights and obligations under this Agreement to a Person
that succeeds to all or substantially all of that Party’s business or assets, whether by sale, merger, operation of law or
otherwise and provided that such Person agrees, in form and substance reasonably acceptable to COH, to be bound as a direct party
to this Agreement in lieu of or in addition to Licensee and provided further that Licensee has complied with its obligations pursuant
to Section 4.5. This Agreement shall be binding upon and inure to the benefit of and be enforceable by the Parties hereto and their
respective successors and permitted assignees. Any transfer or assignment of this Agreement in violation of this Section 14.1 shall
be null and void.

 

14.2         Entire
Agreement. This Agreement and the Research Agreement contains the entire agreement between the Parties relating to the
subject matter hereof, and all prior understandings, representations and warranties between the Parties are superseded by this
Agreement. For clarity, the Original Agreement shall be deemed amended and restated in its entirety by this Agreement, and the
corresponding A&R CD123 License and the corresponding A&R IL-13
License to be executed by the Parties simultaneously herewith, effective as of the A&R Effective Date.

 

14.3         Amendments.
Changes and additional provisions to this Agreement shall be binding on the Parties only if agreed upon in writing and signed by
the Parties.

 

14.4         Applicable
Law. This Agreement shall be construed and interpreted in accordance with the laws of the State of California and all rights
and remedies shall be governed by such laws without regard to principles of conflicts of law.

 

14.5         Force
Majeure. If the performance of this Agreement or any obligations hereunder is prevented, restricted or interfered with
by reason of earthquake, fire, flood or other casualty or due to strikes, riot, storms, explosions, acts of God, war, terrorism,
or a similar occurrence or condition beyond the reasonable control of the Parties, the Party so affected shall, upon giving prompt
notice to the other Parties, be excused from such performance during such prevention, restriction or interference, and any failure
or delay resulting therefrom shall not be considered a breach of this Agreement.

 

    	 	-27-	 

    CONFIDENTIAL

    

  

14.6         Severability.
The Parties do not intend to violate any public policy or statutory common law. However, if any sentence, paragraph, clause or
combination of this Agreement is in violation of any law or is found to be otherwise unenforceable, such sentence, paragraph, clause
or combination of the same shall be deleted and the remainder of this Agreement shall remain binding, provided that such
deletion does not alter the basic purpose and structure of this Agreement.

 

14.7         Notices.
All notices, requests, demands, and other communications relating to this Agreement shall be in writing in the English language
and shall be delivered in person or by mail, international courier or facsimile transmission (with a confirmation copy forwarded
by courier or mail). Notices sent by mail shall be sent by first class mail or the equivalent, registered or certified, postage
prepaid, and shall be deemed to have been given on the date actually received. Notices sent by international courier shall be sent
using a service which provides traceability of packages. Notices shall be sent as follows:

 

	
        Notices to COH:

         

        Office of Technology Licensing

        City of Hope

        1500 East Duarte Road

        Duarte, CA 91010

        Attn: Sr. VP, Center for Applied 

Technology Development

        Fax: 626-301-8175
	
        with a copy to:

         

        Office of General Counsel

        City of Hope

        1500 East Duarte Road

        Duarte, CA 91010

        Attn: General Counsel

        Fax: 626-301-8863

	 	 
	
        Notices to Licensee:

         

        Mustang Bio, Inc.

        2 Gansevoort, 9th Floor

        New York, NY 10014

        Attn: CEO
	
        with a copy to:

         

        Mustang Bio, Inc.

        2 Gansevoort, 9th Floor

        New York, NY 10014

        Attn: Corporate Secretary
	 

 

Either Party may change its address for
notices or facsimile number at any time by sending notice to the other Party.

 

14.8         Independent
Contractor. Nothing herein shall create any association, partnership, joint venture, fiduciary duty or the relation of
principal and agent between the Parties hereto, it being understood that each Party is acting as an independent contractor, and
neither Party shall have the authority to bind the other or the other’s representatives in any way.

 

14.9         Waiver.
No delay on the part of either Party hereto in exercising any power or right hereunder shall operate as a waiver thereof, nor shall
any single or partial exercise of any power or right hereunder preclude other or further exercise thereof or the exercise of any
other power or right. No waiver of this Agreement or any provision hereof shall be enforceable against any Party hereto unless
in writing, signed by the Party against whom such waiver is claimed, and shall be limited solely to the one event.

 

    	 	-28-	 

    CONFIDENTIAL

    

  

14.10         Interpretation.
This Agreement has been prepared jointly and no rule of strict construction shall be applied against either Party. In this Agreement,
the singular shall include the plural and vice versa and the word “including” shall be deemed to be followed by the
phrase “without limitation.” The section headings contained in this Agreement are inserted for convenience only and
shall not affect in any way the meaning or interpretation of this Agreement.

 

14.11         Counterparts.
This Agreement may be executed in counterparts, each of which together shall constitute one and the same Agreement. For purposes
of executing this agreement, a facsimile copy or an emailed PDF of this Agreement, including the signature pages, will be deemed
an original.

 

14.12         Licensee
Certification. Licensee certifies to COH, under penalty of perjury, that Licensee has not been convicted of a criminal
offense related to health care, is not currently debarred, excluded or otherwise ineligible for participation in federally funded
health care programs and has not arranged or contracted (by employment or otherwise) with any employee, contractor, or agent that
it knew or should have known are excluded from participation in any federal health care program, and will not knowingly arrange
or contract with any such individuals or entities during the term of this Agreement. Licensee agrees to notify COH in writing immediately
of any threatened, proposed or actual conviction relating to health care, of any threatened, proposed or actual debarment or exclusion
from participation in federally funded programs, of COH or any employee, contractor or agent of COH. Any breach of this Section
14.12 by Licensee shall be grounds for termination of this Agreement by COH in accordance with Section 8.2.1.

 

14.13         Publicity.
Neither Party may issue a press releases or otherwise disclose the existence or terms of this Agreement without the prior written
consent of the other Party; provided, however, that once the existence or any terms or conditions of this Agreement
has been publicly disclosed in a manner mutually and reasonably agreed-to by the Parties, either Party may republish the facts
previously disclosed without the prior consent of the other Party. COH may, in its sole discretion and without the approval of
Licensee, publicly disclose the existence of this Agreement and the overall potential value of the Agreement to COH, so long as
the detailed and specific terms and conditions of this Agreement are not disclosed. If a third party inquires whether a license
is available, COH may disclose the existence of the Agreement and the extent of its grant in Section 3.1 to such third party, but
will not disclose the name of the Licensee, except where COH is required to release information under either the California Public
Records Act or other applicable law.

 

*      *      *      *      *

 

    	 	-29-	 

    CONFIDENTIAL

    

  

IN WITNESS WHEREOF,
the Parties have executed this Agreement by their duly authorized representatives.

 

	MUSTANG BIO, INC.	 	CITY OF HOPE
	 	 	 
	By:	/s/ Michael S. Weiss	 	By:	/s/ Robert Stone
	 	 	 	 	 
	Name	Michael S. Weiss	 	Name:	Robert Stone
	 	 	 	 	 
	Title:	President & CEO	 	Title:	CEO & President

 

    	 	-30-	 

    CONFIDENTIAL

    

  

EXHIBIT A

 

Form of Charter

 

    	 	-31-

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