Document:

EX-4.1.3

 Exhibit 4.1.3 

SECOND AMENDMENT TO THIRD AMENDED AND RESTATED 

INVESTORS’ RIGHTS AGREEMENT 

AND WAIVER OF REGISTRATION RIGHTS 

THIS SECOND AMENDMENT TO THIRD AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS (this
“Amendment”), which amends that certain Third Amended and Restated Investors’ Rights Agreement dated October 28, 2011, as amended (the “Original Agreement”), by and among RetailMeNot, Inc., a
Delaware corporation (the “Company”), and the persons and entities listed on Exhibit A thereto (each an “Investor” and collectively, the “Investors”), is made and entered
into as of the December 6, 2013. Unless otherwise defined herein, capitalized terms shall have the definitions ascribed to them in the Original Agreement. 

RECITALS 
 WHEREAS, the
parties hereto, being all of the parties to the Original Agreement, desire to amend the Original Agreement and to waive certain rights thereunder as set forth herein. 

AMENDMENT AND WAIVER 
 1.
Section 5.2 of the Original Agreement is hereby amended and restated in its entirety as follows: 
 “Amendment of
Rights. Any provision of this Agreement may be amended and the observance of such provision may be waived (either generally or in a particular instance and either retroactively or prospectively) only with the written consent of the Company
and Investors holding (a) a majority of the Registrable Securities then held by the Investors, (b) a majority of the shares of Common Stock then outstanding which were issued upon conversion of the shares of Series B-3 Preferred Stock and
(c) a majority of the shares of Common Stock then outstanding which were issued upon conversion of the shares of Series BB-3 Preferred stock. Any amendment or waiver effected in accordance with this Section 5.2 shall be binding upon
each Investor, each permitted successor or assignee of such Investor, and the Company; provided, no amendment or waiver that uniquely and adversely affects the rights of any Investor without the consent of such uniquely and adversely affected
Investor. 
 2. All of the obligations, rights, duties and covenants of the Company contained in Section 4 of the Original
Agreement are hereby terminated and Sections 4.1, 4.2, 4.3, 4.4, 4.5 and 4.7 of the Original Agreement shall be of no further force or effect. 

3. In connection with the proposed follow-on public offering of the Company’s Series 1 common stock on or before December 31, 2013
(the “Offering”) the undersigned hereby irrevocably waive (the “Waiver”) any and all rights pursuant to Section 1 of the Original Agreement in connection with the Offering, including, without
limitation, the rights to register any shares, whether now owned or hereafter acquired, of the Company’s capital stock, pursuant to Section 1.4 of the Original Agreement, and any and all notice requirements contained in the
Original Agreement related thereto. 
 4. The undersigned agree and acknowledge that the Company, its advisors and the underwriters will
proceed with the Offering in reliance upon this Amendment and the Waiver. 

 5. This Amendment may be executed in any number of counterparts (by facsimile, PDF electronic delivery or
otherwise), each of which shall be an original, but all of which shall constitute one and the same instrument. The undersigned agree and acknowledge that this Amendment shall be of no force or effect until countersigned by the Company. 

[REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK] 

  
 2 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	COMPANY:
	
	RETAILMENOT, INC.
		
	By:	 	 /s/ G. Cotter Cunningham

		 	G. Cotter Cunningham,
		 	President and Chief Executive Officer

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	INVESTORS:
	
	AUSTIN VENTURES IX, L.P.
		
	By:	 	AV Partners IX, L.P.,
		 	its general partner
		
	By:	 	AV Partners IX, LLC,
		 	its general partner
		
	By:	 	 /s/ Ken DeAngelis

		 	Authorized Representative
	
	AUSTIN VENTURES X, L.P.
		
	By:	 	AV Partners X, L.P.,
		 	its general partner
		
	By:	 	AV Partners X, LLC,
		 	its general partner
		
	By:	 	 /s/ Ken DeAngelis

		 	Member
	
	 Address: 300 West 6th Street, Suite 2300

Austin, Texas 78701-3902
 Attn: C. Thomas Ball

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

	
	G. COTTER CUNNINGHAM
	
	 /s/ G. Cotter Cunningham

	G. Cotter Cunningham

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	Norwest Venture Partners XI, LP
	By:	 	Genesis VC Partners XI, LLC, General Partner
		
	By:	 	NVP Associates, LLC,
		 	Managing Member
		
	By:	 	 /s/ Jeff Crowe

		 	Jeff Crowe
	
	Norwest Venture Partners VII-A, LP
	By:	 	Itasca VC Partners VII-A, LLC, General Partner
		
	By:	 	NVP Associates, LLC,
		 	Managing Member
		
	By:	 	 /s/ Jeff Crowe

		 	Jeff Crowe
	
	Norwest Venture Partners VI-A, LP
	By:	 	Itasca VC Partners VI-A, LLC, General Partner
		
	By:	 	NVP Associates, LLC,
		 	Managing Member
		
	By:	 	 /s/ Jeff Crowe

		 	Jeff Crowe
	
	Address: 525 University Ave., Suite 800
	Palo Alto, CA 94301-1922
	Attn:	 	Kurt Betcher, CFO
	
	With a copy to:
	
	Norwest Venture Partners XI, LP
	525 University Ave., Suite 800
	Palo Alto, CA 94301-1922
	Attn:	 	Bill Myers

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	ADAMS STREET 2010 DIRECT FUND, L.P.
	By:	 	ASP 2010 Direct Management, LLC, its
		 	General Partner
	By:	 	Adams Street Partners, LLC, its
		 	Managing Member
		
	By:	 	 /s/ Robin Murray

		 	Partner
	
	ADAMS STREET 2009 DIRECT FUND, L.P.
	By:	 	ASP 2009 Direct Management, LLC, its
		 	General Partner
	By:	 	Adams Street Partners, LLC, its
		 	Managing Member
		
	By:	 	 /s/ Robin Murray

		 	Partner
	
	ADAMS STREET 2008 DIRECT FUND, L.P.
	By:	 	ASP 2008 Direct Management, LLC, its
		 	General Partner
	By:	 	Adams Street Partners, LLC, its
		 	Managing Member
		
	By:	 	 /s/ Robin Murray

		 	Partner
	
	Address: c/o Adams Street Partners, LLC
	One North Wacker Drive, Suite 2200
	Chicago, IL 60606-2823
	Attn:	 	Sejal Shah

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	GOOGLE VENTURES 2011, L.P.
		
	By:	 	Google Ventures 2011 GP, L.L.C.,
		 	its general partner
		
	By:	 	 /s/ William J. Maris

	Name: William J. Maris
	Title: Member

 
			
		
	Address:	 	1600 Amphitheatre Parkway
		 	Mountain View, CA 94043
		 	Attn: Karim Faris
	
	With a copy to:
	
	        Google Ventures 2011, L.P.
	        Attn: General Counsel, Google Ventures
	        Email: gv-notice@google.com

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

	
	 /s/ Duncan Jennings

	Duncan Jennings
	
	 /s/ Max Jennings

	Max Jennings
	
	 /s/ Richard Foister

	Richard Foister
	
	 /s/ Antonio Argiolas

	Antonio Argiolas
	
	 /s/ Daniel Bower

	Daniel Bower
	
	 /s/ John-Paul Jones

	John-Paul Jones

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	INSTITUTIONAL VENTURE PARTNERS XIII L.P.
		
	By:	 	Institutional Venture Management XIII LLC
	Its:	 	General Partner
		
	By:	 	 /s/ Jules Maltz

		
	Name:	 	 Jules Maltz

		
	Title:	 	 Authorized Signatory

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	JP MORGAN DIGITAL GROWTH FUND L.P.
		
	By:	 	J.P. Morgan Investment Management Inc.
	Its:	 	Investment Advisor
		
	By:	 	 /s/ Ashmi Mehrotra

		
	Name:	 	 Ashmi Mehrotra

		
	Title:	 	 Managing Director

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	522 FIFTH AVENUE FUND, L.P.
		
	By:	 	J.P. Morgan Investment Management Inc.
	Its:	 	Investment Advisor
		
	By:	 	 /s/ Ashmi Mehrotra

		
	Name:	 	 Ashmi Mehrotra

		
	Title:	 	 Managing Director

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	J.P. MORGAN SECONDARY PRIVATE EQUITY INVESTORS II, L.P.
		
	By:	 	J.P. Morgan Investment Management Inc.
	Its:	 	Investment Advisor
		
	By:	 	 /s/ Ashmi Mehrotra

		
	Name:	 	 Ashmi Mehrotra

		
	Title:	 	 Managing Director

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

	
	Executed by King Holdings (Vic) Pty Ltd ACN 147 435 970 in its capacity as trustee for the King Holdings Trust, in accordance with S. 127 of the Corporations Act 2001 by being signed by the
following officer:
	
	 /s/ Guy Phillip King

	Guy Phillip King being the sole director and company secretary
	
	
	Executed by Clark/Kirk Holdings Pty Ltd ACN 147 455 767 in its capacity as trustee for the Clark/Kirk Holdings Trust, in accordance with S. 127 of the Corporations Act 2001 by being signed by the following
officer:
	
	 /s/ Bevan Heath Clark

	Bevan Heath Clark being the sole director and company secretary

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	MOUVEO, a French société à responsibilité limitée, registered with the Trade and Companies Registry of Vannes under number 539 803 775
		
	By:	 	 /s/ Olivier David

		
	Name:	 	 Olivier David

		
	Title:	 	 Chief Executive Officer

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	INVENTUZ, a French société à responsibilité limitée, registered with the Trade and Companies Registry of Vannes under number 539 805 572
		
	By:	 	 /s/ Francois Larvor

		
	Name:	 	 Francois Larvor

		
	Title:	 	 Chief Executive Officer

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	THE 2010 GLOZMAN FAMILY TRUST DATED JULY 13, 2010
		
	By:	 	 /s/ M. Glozman

		
	Name:	 	 M. Glozman

		
	Title:	 	 Trustee

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

	
	JUSTIN HALLORAN
	
	 /s/ Justin Halloran

	Justin Halloran

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

	
	ARBOR GREEN II, LP
	
	 /s/ Thomas P. Borders

	Thomas P. Borders, Trustee

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

	
	PETER MORSE
	
	 /s/ Peter Morse

	Peter Morse

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	MOOSE POND INVESTMENTS, LP
		
	By:	 	 /s/ Brian Sharples

	Name:	 	Brian Sharples
	Title:	 	Partner

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTS 

 This Amendment has been executed by the undersigned, effective as of the date first written
above. 
  

			
	MTG PORTFOLIO, LTD.
		
	By:	 	Midtown Group, Inc., its general partner
		
	By:	 	 /s/ Thomas P. Borders

	Name:	 	Thomas P. Borders
	Title:	 	President

  
 SECOND AMENDMENT TO
THIRD A&R INVESTORS’ RIGHTS AGREEMENT AND WAIVER OF REGISTRATION RIGHTSEX-10.1

 Exhibit 10.1 

Execution Copy 
 EMPLOYMENT
AGREEMENT 
 This EMPLOYMENT AGREEMENT (this “Agreement”), dated December 5, 2013 and effective as of the
Commencement Date (as defined in Section 1.2), is by and between REGADO BIOSCIENCES, INC., a Delaware corporation (the “Company”) and MICHAEL A. METZGER (the “Executive”). 

W I T N E S S E T H: 

WHEREAS, the Company desires to employ the Executive as its President and Chief Operating Officer and the Executive desires to accept
such employment, on the terms and conditions set forth in this Agreement; and 
 NOW, THEREFORE, in consideration of the promises and
the mutual covenants and agreements contained herein and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto, intending to be legally bound hereby, agree as follows: 

ARTICLE 1 
 EMPLOYMENT; TERM OF
AGREEMENT 
 Section 1.1. Employment and Acceptance. During the Term (as defined in Section 1.2), the Company
shall employ the Executive, and the Executive shall accept such employment and serve the Company, in each case, subject to the terms and conditions of this Agreement. 

Section 1.2. Term. The employment relationship hereunder shall be for the period (such period of the employment relationship shall
be referred to herein as the “Term”) commencing on such date as is mutually agreed between the Company and the Executive, but not later than December 9, 2013 (the “Commencement Date”) and ending upon the
termination of the Executive’s employment hereunder by either party hereto pursuant to the terms of Section 4.1, Section 4.2, Section 4.3 or Section 4.4. In the event that the Executive’s
employment with the Company hereunder terminates, the Company’s obligation to continue to pay, after the Termination Date (as defined in Section 4.2(b)), Base Salary (as defined in Section 3.1(a)), Annual Bonus (as
defined in Section 3.1(c)) and other unaccrued benefits shall terminate, except as may be provided for in ARTICLE 4. 

ARTICLE 2 
 TITLE; DUTIES AND
OBLIGATIONS; LOCATION 
 Section 2.1. Title. The Company shall employ the Executive to render exclusive and full-time
services to the Company. The Executive shall serve in the capacity of President and Chief Operating Officer. 
 Section 2.2.
Duties. The Executive shall report to the Company’s Chief Executive Officer (the “CEO”) and be subject to the lawful direction of the Company’s Board of Directors (the “Board”) and/or the CEO. The
Executive agrees to perform to the best of his ability, experience and talent those acts and duties, consistent with the position of President and Chief Operating Officer, as the Board and/or the CEO shall from time to time direct. Without

 
limitation, the Company currently anticipates that the Executive’s initial duties will be heavily focused on business development activities, as well as managing legal interactions with
outside corporate counsel, interacting with the Company’s Chief Scientific Officer to manage legal issues associated with the Company’s intellectual property estate, and directing Human Resources, Public Relations, Project Management, and
Marketing. During the Term, the Executive also shall serve in such other executive-level positions or capacities as may, from time to time, be reasonably requested by the Board and/or the CEO, including, without limitation (subject to election,
appointment, re-election or re-appointment, as applicable) as (a) a member of the Board and/or as a member of the board of directors or similar governing body of any of the Company’s subsidiaries or other Affiliates (as defined below),
(b) an officer of any of the Company’s subsidiaries or other Affiliates, and/or (c) a member of any committee of the Company and/or any of its subsidiaries or other Affiliates, in each case, for no additional compensation. As used in
this Agreement, “Affiliate” of any individual or entity means any other individual or entity that directly or individual controls, is controlled by, or is under common control with, the individual or entity. 

Section 2.3. Compliance with Policies, etc. During the Term, the Executive shall be bound by, and comply fully with, all of the
Company’s policies and procedures for employees and officers in place from time to time, including, but not limited to, all terms and conditions set forth in the Company’s employee handbook, compliance manual, codes of conduct and any
other memoranda and communications applicable to the Executive pertaining to the policies, procedures, rules and regulations, as currently in effect and as may be amended from time to time. These policies and procedures include, among other things
and without limitation, the Executive’s obligations to comply with the Company’s rules regarding confidential and proprietary information and trade secrets. 

Section 2.4. Time Commitment. During the Term, the Executive shall use his best efforts to promote the interests of the Company
(including its subsidiaries and other Affiliates) and shall devote all of his business time, ability and attention to the performance of his duties for the Company and shall not, directly or indirectly, render any services to any other person or
organization, whether for compensation or otherwise, except with the Board’s prior written consent, provided that the foregoing shall not prevent the Executive from (i) participating in charitable, civic, educational, professional,
community or industry affairs, (ii) managing the Executive’s passive personal investments, or (iii) subject to the prior written approval of the Board (which approval shall not be unreasonably withheld), (A) serving, during the
first year of the Term, on the board of directors (or similar governing body) of not more than one (1) other corporation (or other business entity) that is not a competitor of the Company, its subsidiaries or any of its other Affiliates (as
determined by the Board) and (B) serving, after the one-year anniversary of the Commencement Date, on the board of directors (or similar governing body) of not more than two (2) other corporations (or other business entity) that are not
competitors of the Company, its subsidiaries or any of its other Affiliates (as determined by the Board), as long as, in each case, such activities individually or in the aggregate do not materially interfere or conflict with the Executive’s
duties hereunder or create a potential business or fiduciary conflict (in each case, as determined by the Board). 
 Section 2.5.
Location. The Executive’s principal place of business for the performance of his duties under this Agreement shall be at the principal executive office of the Company (currently located in Basking Ridge, New Jersey). Notwithstanding, the
foregoing, the Executive shall be required to travel as necessary to perform his duties hereunder. 

  
 -2- 

 ARTICLE 3 

COMPENSATION AND BENEFITS; EXPENSES 

Section 3.1. Compensation and Benefits. For all services rendered by the Executive in any capacity during the Term (including,
without limitation, serving as an officer, director or member of any committee of the Company or any of its subsidiaries or other Affiliates), the Executive shall be compensated as follows (subject, in each case, to the provisions of ARTICLE
4 below): 
 (a) Base Salary. During the Term, the Company shall pay the Executive a base salary (the “Base
Salary”) at the annualized rate of $405,000, which shall be subject to customary withholdings and authorized deductions and be payable in equal installments in accordance with the Company’s customary payroll practices in place from
time to time. The Executive’s Base salary shall be subject to periodic adjustments as the Board and/or the Compensation Committee of the Board (the “Compensation Committee”) shall in its/their discretion deem appropriate;
provided that the Company shall not decrease the Executive’s Base Salary by more than 20% except in the instance of an across-the-board decrease in base salary applicable to all executives of the Company in substantially the same
proportion. As used in this Agreement, the term “Base Salary” shall refer to Base Salary as may be adjusted from time to time. 

(b) Sign-On Bonus. Provided that the Executive executes this Agreement and commences employment with the Company by no later than
December 9, 2013, the Executive shall (subject to the terms and conditions of Section 3.1(b)) be entitled to a one-time sign-on bonus in the aggregate amount of $150,000 (the “Sign-On Bonus”), which Sign-On Bonus
shall be subject to customary withholdings and authorized deductions. The Sign-On Bonus will be paid to Executive in two equal installments as follows: (i) the first installment of $75,000 (less customary withholdings and authorized deductions)
will be paid on the Commencement Date (or as soon thereafter as administratively practical, but in no event later than December 31, 2013); and (ii) the second installment of $75,000 (less customary withholdings and authorized deductions)
will be paid at the time 2013 performance bonuses are paid to Company employees awarded such bonuses (currently anticipated by the Company to occur by December 31, 2013 or by January 31, 2014), but in no event later than March 15,
2014; provided, however, notwithstanding anything set forth herein to the contrary, the Executive shall not be entitled to receive the second installment of the Sign-On Bonus (or any portion thereof) if he (i) terminates his employment
with the Company other than for (A) Good Reason (as defined in Section 4.1(c)) pursuant to Section 4.1 or (B) Post-CIC Good Reason (as defined in Section 4.3(c)) pursuant to Section 4.3 or
(ii) is terminated by the Company for Cause (as defined in Section 4.1(b) below), in each case, prior to the date that the second installment of the Sign-On Bonus is payable. To induce the Company to agree to provide the Executive
with the Sign-On Bonus, the Executive has indicated his intention to remain employed by the Company for at least one year. Accordingly, the Executive agrees that if he (i) voluntarily terminates his employment with the Company other than for
(A) Good Reason pursuant to Section 4.1 or (B) Post-CIC Good Reason pursuant to Section 4.3 or (ii) is terminated by the Company for Cause, in each case, prior to the one-year anniversary of the Commencement
Date, the Executive will promptly repay the Sign-On Bonus (to the extent paid to the Executive) to the Company upon demand. 

  
 -3- 

 (c) Annual Bonus. For each calendar year ending during the Term (beginning with the
calendar year ending December 31, 2014), the Executive shall be eligible to receive an annual bonus (the “Annual Bonus”) with a target amount equal to forty percent (40%) of the Base Salary earned by the Executive for such
calendar year (the “Target Annual Bonus”). The actual amount of each Annual Bonus will be based upon the level of achievement of the Company’s corporate objectives as established by the Board or the Compensation Committee
(taking into account the input of the CEO with respect to the establishment of the corporate objectives) and the Executive’s individual objectives as established by the Board or the Compensation Committee (taking into account the input of the
CEO and the Executive with respect to the establishment of the Executive’s individual objectives) for the calendar year with respect to which such Annual Bonus relates. The determination of the level of achievement of the corporate objectives
for a year shall be made by the Board or the Compensation Committee (taking into account the input of the CEO with respect to the level of achievement of the corporate objectives) and the Executive’s individual performance objectives for a year
shall be made by the Board or the Compensation Committee (taking into account the input of the CEO and the Executive with respect to the level of achievement of the Executive’s individual objectives), in each case, in the Board’s or the
Compensation Committee’s reasonable discretion. Each Annual Bonus for a calendar year, to the extent earned, will be paid in a lump sum in the same or the following calendar year, but not later than the 75th day of such following calendar year.
The Annual Bonus shall not be deemed earned until the date that it is paid. Accordingly, in order for the Executive to receive an Annual Bonus, the Executive must be actively employed by the Company at the time of such payment. For calendar year
2014 and 2015 only, in the event of achievement of a Performance Event (as defined below) at any time on or prior to December 31, 2015, the Executive will receive a lump sum cash bonus (the “Performance Event Bonus”) for the
calendar year during which the Performance Event occurs equivalent to 100% of Base Salary for such calendar year during which the Performance Event occurs (which shall be in lieu of the Target Annual Bonus amount for 2014 or 2015, as applicable),
payable in the same calendar year in which the Performance Event (if any) occurs or within the first 75 days of the following calendar year, subject to the Executive’s continued active employment with the Company at the time of such
payment. As used in this Section 3.1(c) and in Section 3.1(d), “Performance Event” means, at any time on or before December 31, 2015, but before the Company raises cumulatively $90,000,000 through a
financing or series of financings, the Company’s consummation of a transaction resulting in a merger, sale of equity to a strategic partner at a price greater than then current Fair Market Value as defined in the 2013 Plan (as defined below),
sale of assets, partnering, joint venture or licensing transaction, in each case yielding sufficient net cash proceeds to the Company to reduce the Company’s capital needs to complete the REGULATE-PCI study by at least $45,000,000, as
determined by the Board of Directors or the Compensation Committee. For the avoidance of doubt, the Executive shall only be eligible to receive one Performance Event Bonus (i.e., in no event is the Executive eligible to receive a Performance
Event Bonus for both 2014 and 2015). If the Executive does not become entitled to the Performance Event Bonus for 2014 or 2015, then he shall remain eligible for the regular Annual Bonus for 2014 and 2015 in accordance with the terms provided
herein. 

  
 -4- 

 (d) Equity Compensation. 

(i) Initial Option Grant. Subject to formal approval by the Compensation Committee of the Board, at the next meeting of the Compensation
Committee held on or following the Commencement Date, the Executive will be granted options (the “Initial Option Grant”) to purchase (at a per share exercise price equal to fair market value per share of the Company’s common
stock as of the date of grant in accordance with the terms of the 2013 Plan (as defined below)) a number of shares of the Company’s common stock equivalent to 2.25% of the Company’s common stock as of the Commencement Date, calculated on a
fully-diluted basis (including unallocated shares reserved pursuant to the 2013 Plan, as well as all shares subject to warrants, options and other equity incentive awards that have been issued and are outstanding) (“Fully Diluted
Basis”). The Initial Option Grant shall be subject to the terms and conditions established within the Company’s 2013 Equity Compensation Plan (as the same may be amended from time to time) or any successor equity compensation plan as
may be in place from time to time (the “2013 Plan”) and separate stock option agreement between the Company and the Executive (the “Initial Stock Option Agreement”). The Initial Stock Option Agreement will provide
that, among other things: (A) shares covered by the Initial Option Grant representing 0.4375% of the Company’s common stock as of the Commencement Date, calculated on a Fully-Diluted Basis, shall be fully vested as of the date of the
Initial Option Grant, (B) shares covered by the Initial Option Grant representing 1.3125% of the Company’s common stock as of the Commencement Date, calculated on a Fully Diluted Basis (the “Time-Based Interests”), shall
vest ratably in equal monthly installments over a three (3) year period, commencing with the one (1) month anniversary of the Commencement Date and continuing on the same day of each calendar month thereafter through and including the
thirty-six (36) month anniversary of the Commencement Date; and (B) shares covered by the Initial Option Grant representing 0.5% of the Company’s common stock as of the Commencement Date, calculated on a Fully Diluted Basis (the
“Performance-Based Interests”), shall vest only upon the achievement of a Performance Event, in each case, subject to the Executive’s continued employment with the Company on the applicable vesting date. 

(ii) The Executive also shall be eligible to receive from time to time additional Stock Options, Stock Units, Performance Shares, Performance
Units, Incentive Bonus Awards, Other Cash-Based Awards and/or Other Stock-Based Awards (as such capitalized terms are defined in the 2013 Plan), in amounts, if any, to be approved by the Board or the Compensation Committee in its discretion. 

(e) Benefit Plans. The Executive shall be entitled to participate in all employee benefit plans and programs (excluding severance plans
(if any)) generally made available by the Company to senior executives of the Company (which plans and programs currently include, inter alia, group family health and dental insurance, group life and disability insurance and 401(k) plan), to
the extent permissible under the general terms and provisions of such plans or programs and in accordance with the provisions thereof. The Company may amend, modify or rescind any employee benefit plan or program and/or change employee contribution
amounts to benefit costs without notice in its discretion. 

  
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 (f) Paid Vacation. The Executive shall be entitled to paid vacation days in accordance
with the Company’s vacation policies in effect from time to time for its executive team; provided, however, that the Executive shall be entitled to no less than twenty (20) paid vacation days per calendar year during the Term. 

Section 3.2. Expense Reimbursement. The Company shall reimburse the Executive during the Term, in accordance with the
Company’s expense reimbursement policies in place from time, for all reasonable out-of-pocket business expenses incurred by the Executive in the performance of his duties hereunder. Further, but without duplication, the Company will reimburse
the Executive for (a) the reasonable expenses the Executive incurs for travel between his home in Chappaqua, New York and the Company’s office in Basking Ridge, New Jersey and (b) the reasonable expenses the Executive incurs in
connection with his lodging in the Basking Ridge, New Jersey area (but, in each case, specifically excluding any personal travel or lodging expenses); provided, however, in no event shall the reimbursement amount for such travel and lodging
expenses exceed $25,000 per year. In order to receive any such reimbursements, the Executive shall furnish to the Company documentary evidence of each such expense in the form required to comply with the Company’s policies in place from time to
time. 
 ARTICLE 4 

TERMINATION OF EMPLOYMENT 

Section 4.1. Termination Without Cause or for Good Reason. 

(a) The Company may terminate the Executive’s employment hereunder at any time without Cause (other than by reason of death or
Disability) upon written notice to the Executive. The Executive may terminate his employment hereunder at any time on or before the twelve (12) month anniversary of the Commencement Date for Good Reason upon written notice to the Company. 

(b) As used in this Agreement, “Cause” means: (i) a material act, or act of fraud, committed by the Executive that is
intended to result in the Executive’s personal enrichment to the detriment or at the expense of the Company or any of its Affiliates; (ii) the Executive is convicted of a felony; (iii) gross negligence or willful misconduct by the
Executive, or failure by the Executive to perform the duties or obligations reasonably assigned to the Executive by the Board or the CEO from time to time, which is not cured upon ten (10) days prior written notice (unless such negligence,
misconduct or failure is not susceptible to cure, as determined in the reasonable discretion of the Board); or (iv) the Executive violates the Covenants Agreement (as defined in Section 5.1 below). 

(c) As used in this Agreement, “Good Reason” means the occurrence of any of the following events, in each case, both prior to
the twelve (12) month anniversary of the Commencement Date and provided that a Change of Control has not been consummated prior to the occurrence of any of such events: (1) a material breach by the Company of the terms of this Agreement;
(2) a reduction in the Executive’s Base Salary by more than 20%, unless the Executive’s Base Salary is reduced by more than 20% in connection with a general reduction in base compensation that affects all Company executives in
substantially the same proportions; (3) a material diminution in the Executive’s title of President and Chief Operating Officer; (4) a requirement that the Executive report to a corporate officer or employee other than the CEO or
(5) a relocation by the Company of the Executive’s principal place of business for the 

  
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performance of his duties under this Agreement to a location that is anywhere outside of a 50 mile radius of Basking Ridge, New Jersey; provided, however, that the Executive must notify
the Company within ninety (90) days of the occurrence of any of the foregoing conditions that he considers it to be a “Good Reason” condition and provide the Company with at least thirty (30) days in which to cure the condition.
If the Executive fails to provide this notice and cure period prior to his resignation, or resigns more than six (6) months after the initial existence of the condition, his resignation will not be deemed to be for “Good Reason.” 

(d) If the Executive’s employment terminates pursuant to Section 4.1(a), the Executive shall, in full discharge of all of the
Company’s obligations to the Executive, be entitled to receive, and the Company’s sole obligation to the Executive under this Agreement or otherwise shall be to pay or provide to the Executive, the following: 

(i) the Accrued Obligations (as defined in Section 4.2(b)); and 

(ii) subject to Section 4.5 and Section 4.6: 

(A) payments equal to the sum of twelve (12) months of the Executive’s Base Salary (at the rate in effect immediately
prior to the Termination Date) and the Executive’s Target Bonus for the calendar year in which the Termination Date occurs (in each case, less applicable withholdings and authorized deductions), to be paid semi-monthly in accordance with the
Company’s customary payroll practices, commencing sixty (60) days following such termination of employment (the “Severance Payments”); and 

(B) if the Executive then participates in the Company’s medical and/or dental plans and the Executive timely elects to
continue and maintain group health plan coverage pursuant to the Consolidated Omnibus Budget Reconciliation Act of 1985, as amended (“COBRA”), the Company will pay monthly, on the Executive’s behalf, a portion of the cost of
such coverage for the twelve (12) months after the Termination Date, which payments will be equal to the amount of the monthly premium for such coverage, less the amount that the Executive would have been required to pay if the Executive had
remained an active employee of the Company (the “COBRA Assistance”); provided, however, that if and to the extent that the Company may not provide such COBRA Assistance without incurring tax penalties or violating any
requirement of the law, the Company shall use its commercially reasonable best efforts to provide substantially similar assistance in an alternative manner provided that the cost of doing so does not exceed the cost that the Company would have
incurred had the COBRA Assistance been provided in the manner described above or cause a violation of Section 409A (as defined in Section 5.17). 

Section 4.2. Termination for Cause; Voluntary Termination without Good Reason. 

(a) The Company may terminate the Executive’s employment hereunder at any time for Cause upon written notice to the Executive. The
Executive may voluntarily terminate his employment hereunder at any time for any reason or no reason upon thirty (30) days prior written notice to the Company; provided, however, the Company reserves the right, upon written

  
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notice to the Executive, to accept the Executive’s notice of resignation and to accelerate such notice and make the Executive’s resignation effective immediately, or on such other date
prior to Executive’s intended last day of work as the Company deems appropriate. It is understood and agreed that the Company’s election to accelerate Executive’s notice of resignation shall not be deemed a termination by the Company
without Cause for purposes of Section 4.1 of this Agreement or otherwise, constitute Good Reason for purposes of Section 4.1 of this Agreement or otherwise or constitute Post-CIC Good Reason (as defined in
Section 4.3) for purposes of Section 4.3 of this Agreement or otherwise. 
 (b) If the Executive’s employment
is terminated pursuant to Section 4.2(a), the Executive shall, in full discharge of all of the Company’s obligations to the Executive, be entitled to receive, and the Company’s sole obligation under this Agreement or otherwise
shall be to pay or provide to the Executive, the following (collectively, the “Accrued Obligations”): 
 (i)
the Executive’s earned, but unpaid, Base Salary through the final date of the Executive’s employment by the Company (the “Termination Date”), payable in accordance with the Company’s standard payroll practices; 

(ii) the Executive’s accrued, but unused, vacation (in accordance with the Company’s policies); 

(iii) expenses reimbursable under Section 3.2 above incurred on or prior to the Termination Date but not yet
reimbursed; and 
 (iv) any amounts or benefits that are vested amounts or vested benefits or that the Executive is otherwise
entitled to receive under any plan, program, policy or practice (with the exception of those, if any, relating to severance) on the Termination Date, in accordance with such plan, program, policy, or practice. 

Section 4.3. Termination for Post-CIC Good Reason within 12 Months following a Change in Control. 

(a) Notwithstanding the provisions of Section 4.2, if the Executive resigns for Post CIC-Good Reason within twelve
(12) months following a Change in Control of the Company, the provisions of this Section 4.3 shall control. 
 (b) As used
in this Agreement, “Change in Control” means (x) a change in ownership of the Company under clause (i) below or (y) a change in the ownership of a substantial portion of the assets of the Company under clause
(ii) below: 
 (i) Change in the Ownership of the Company. A change in the ownership of the Company shall occur
on the date that any one person, or more than one person acting as a group (as defined in clause (iii) below), acquires ownership of capital stock of the Company that, together with capital stock held by such person or group, constitutes more
than 50 percent of the total fair market value or total voting power of the capital stock of the Company. However, if any one person or more than one person acting as a group, is considered to own more than 50 percent of the total fair market value
or total voting power of the capital 

  
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stock of the Company, the acquisition of additional capital stock by the same person or persons shall not be considered to be a change in the ownership of the Company. An increase in the
percentage of capital stock owned by any one person, or persons acting as a group, as a result of a transaction in which the Company acquires capital stock in the Company in exchange for property will be treated as an acquisition of stock for
purposes of this paragraph. 
 (ii) Change in the Ownership of a Substantial Portion of the Company’s Assets. A
change in the ownership of a substantial portion of the Company’s assets shall occur on the date that any one person, or more than one person acting as a group (as defined in clause (iii) below), acquires (or has acquired during the
12-month period ending on the date of the most recent acquisition by such person or persons) assets from the Company that have a total gross fair market value equal to or more than 80 percent of the total gross fair market value of all of the assets
of the Company immediately prior to such acquisition or acquisitions. For this purpose, gross fair market value means the value of the assets of the Company, or the value of the assets being disposed of, determined without regard to any liabilities
associated with such assets. There is no Change in Control under this clause (ii) when there is a transfer to an entity that is controlled by the shareholders of the Company immediately after the transfer, as provided below in this clause (ii).
A transfer of assets by the Company is not treated as a change in the ownership of such assets if the assets are transferred to (a) a shareholder of the Company (immediately before the asset transfer) in exchange for or with respect to its
capital stock, (b) an entity, 50 percent or more of the total value or voting power of which is owned, directly or indirectly, by the Company, (c) a person, or more than one person acting as a group, that owns, directly or indirectly, 50
percent or more of the total value or voting power of all the outstanding capital stock of the Company, or (d) an entity, at least 50 percent of the total value or voting power of which is owned, directly or indirectly, by a person described in
clause (ii)(c) of this paragraph. For purposes of this clause (ii), a person’s status is determined immediately after the transfer of the assets. 

(iii) Persons Acting as a Group. For purposes of clauses (i) and (ii) above, persons will not be considered to
be acting as a group solely because they purchase or own capital stock or purchase assets of the Company at the same time. However, persons will be considered to be acting as a group if they are owners of a corporation that enters into a merger,
consolidation, purchase or acquisition of assets or capital stock, or similar business transaction with the Company. If a person, including an entity, owns stock in both corporations that enter into a merger, consolidation, purchase or acquisition
of assets or capital stock, or similar transaction, such shareholder is considered to be acting as a group with other shareholders in a corporation only with respect to the ownership in that corporation before the transaction giving rise to the
change and not with respect to the ownership interest in the other corporation. For purposes of this paragraph, the term “corporation” shall have the meaning assigned such term under Treasury Regulation section 1.280G-1, Q&A-45. 

  
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 (iv) Each of clauses (i) through (iii) above shall be construed and
interpreted consistent with the requirements of Section 409A and any Treasury Regulations or other guidance issued thereunder. 
 (c)
As used in this Agreement, “Post-CIC Good Reason” means the occurrence of any of the following: (1) a material breach by the Company of the terms of this Agreement; (2) a material reduction in the Executive’s Base
Salary; (3) a material diminution in the Executive’s authority, duties or responsibilities; or (4) a relocation by the Company of the Executive’s principal place of business for the performance of his duties under this Agreement
to a location that is anywhere outside of a 50 mile radius of Basking Ridge, New Jersey; provided, however, that the Executive must notify the Company within ninety (90) days of the occurrence of any of the foregoing conditions
that he considers it to be a “Post-CIC Good Reason” condition and provide the Company with at least thirty (30) days in which to cure the condition. If the Executive fails to provide this notice and cure period prior to his
resignation, or resigns more than six (6) months after the initial existence of the condition, his resignation will not be deemed to be for “Post-CIC Good Reason.” 

(d) If the Executive’s employment terminates pursuant to Section 4.3(a) (i.e., the Executive resigns for Post-CIC Good
Reason within twelve (12) months following a Change in Control of the Company), the Executive shall, in full discharge of all of the Company’s obligations to the Executive, be entitled to receive, and the Company’s sole obligation to
the Executive under this Agreement or otherwise shall be to pay or provide to the Executive, the following: 
 (i) the
Accrued Obligations; and 
 (ii) subject to Section 4.5 and Section 4.6: 

(a) the Severance Payments, payable in accordance with the terms of Section 4.1(d)(ii)(A); and 

(b) if the Executive then participates in the Company’s medical and/or dental plans and the Executive timely elects to continue and
maintain group health plan coverage pursuant to COBRA, the Company will provide the COBRA Assistance, which COBRA Assistance will be payable in accordance with, and subject to the terms set forth in, Section 4.1(d)(ii)(B). 

Section 4.4. Termination Resulting from Death or Disability. 

(a) As the result of any Disability suffered by the Executive, the Company may, upon five (5) days prior notice to the Executive,
terminate the Executive’s employment under this Agreement. The Executive’s employment shall automatically terminate upon his death. 

(b) “Disability” means a determination by the Company in accordance with applicable law that as a result of a physical or
mental injury or illness, the Executive is unable to perform the essential functions of his job with or without reasonable accommodation for a period of (i) ninety (90) consecutive days; or (ii) one hundred twenty (120) days
during any twelve (12) month period. 

  
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 (c) If the Executive’s employment is terminated pursuant to Section 4.4(a), the
Executive or the Executive’s estate, as the case may be, shall be entitled to receive, and the Company’s sole obligation under this Agreement or otherwise shall be to pay or provide to the Executive or the Executive’s estate, as the
case may be, the Accrued Obligations. 
 Section 4.5. Release Agreement. In order to receive the Severance Payments or the COBRA
Assistance set forth in Section 4.1 or Section 4.3 (in each case, if eligible), the Executive must timely execute (and not revoke) a separation agreement and general release (the “Release Agreement”) in a
customary form as is determined to be reasonably necessary by the Company in its good faith and reasonable discretion. If the Executive is eligible for Severance Payments and COBRA Assistance pursuant to Section 4.1 or
Section 4.3, the Company will deliver the Release Agreement to the Executive within seven (7) calendar days following the Termination Date. The Severance Payments and COBRA Assistance are subject to the Executive’s execution of
such Release Agreement within 45 days of the Executive’s receipt of the Release Agreement and the Executive’s non-revocation of such Release Agreement. 

Section 4.6. Post-Termination Breach. Notwithstanding anything to the contrary contained in this Agreement, the Company’s
obligations to provide the Severance Payments and the COBRA Assistance will immediately cease if the Executive breaches any of the provisions of the Covenants Agreement, the Release Agreement or any other agreement the Executive has with the
Company, or if any provision of those agreements is determined to be unenforceable, to any extent, by a court or arbitration panel, whether by preliminary or final adjudication. 

Section 4.7. Removal from any Boards and Position. If the Executive’s employment is terminated for any reason under this
Agreement, he shall be deemed (without further action, deed or notice) to resign (i) if a member, from the Board or board of directors (or similar governing body) of any Affiliate of the Company or any other board to which he has been appointed
or nominated by or on behalf of the Company and (ii) from all other positions with the Company or any subsidiary or other Affiliate of the Company, including, but not limited to, as an officer of the Company and any of its subsidiaries or other
Affiliates. 
 Section 4.8. Equity Vesting Acceleration. In the event that, within twelve (12) months following a Change in
Control of the Company, the Company terminates the Executive’s employment hereunder without Cause (other than by reason of death or Disability) or the Executive resigns for Post-CIC Good Reason, all stock options and other awards that the
Executive may have under the 2013 Plan (including the Time-Based Interests and the Performance-Based Interests of the Initial Option Grant) shall vest and, in the case of stock options or like awards, become exercisable, to the extent not already
vested and (if applicable) exercisable, on the Termination Date. 

  
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 ARTICLE 5 

GENERAL PROVISIONS 

Section 5.1. Company Proprietary Information, Inventions, and Noncompetition Agreement. The Executive agrees to execute and be
bound by the Proprietary Information, Inventions, and Noncompetition Agreement (“Covenants Agreement”) attached hereto as Schedule A, the terms of which are incorporated herein by reference. The Covenants Agreement shall
survive the termination of this Agreement and the Executive’s employment by the Company for the applicable period(s) set forth therein. 

Section 5.2. Legal Fees. The Company hereby agrees to pay for the reasonable legal fees actually incurred by the Executive in
connection with the review and negotiation of this Agreement by his independent legal counsel in an amount not to exceed $15,000. 

Section 5.3. Entire Agreement. This Agreement and the Covenants Agreement contain the entire agreement of the parties hereto with
respect to the terms and conditions of the Executive’s employment during the Term and activities following termination of this Agreement and the Executive’s employment with the Company and supersede any and all prior agreements and
understandings, whether written or oral, between the parties hereto with respect to the subject matter of this Agreement or the Covenants Agreement. Each party hereto acknowledges that no representations, inducements, promises or agreements, whether
oral or in writing, have been made by any party, or on behalf of any party, which are not embodied herein or in the Covenants Agreement. No agreement, promise or statement not contained in this Agreement or the Covenants Agreement shall be valid and
binding, unless agreed to in writing and signed by the parties sought to be bound thereby. 
 Section 5.4. No Other Contracts.
The Executive represents and warrants to the Company that neither the execution and delivery of this Agreement by the Executive nor the performance by the Executive of the Executive’s obligations hereunder, shall constitute a default under or a
breach of the terms of any other agreement, contract or other arrangement, whether written or oral, to which the Executive is a party or by which the Executive is bound, nor shall the execution and delivery of this Agreement by the Executive nor the
performance by the Executive of his duties and obligations hereunder give rise to any claim or charge against either the Executive, the Company or any Affiliate, based upon any other contract or other arrangement, whether written or oral, to which
the Executive is a party or by which the Executive is bound. The Executive further represents and warrants to the Company that he is not a party to or subject to any restrictive covenants, legal restrictions or other agreement, contract or
arrangement, whether written or oral, in favor of any entity or person which would in any way preclude, inhibit, impair or limit the Executive’s ability to perform his obligations under this Agreement, including, but not limited to,
non-competition agreements, non-solicitation agreements or confidentiality agreements. The Executive shall defend, indemnify and hold the Company harmless from and against all claims, actions, losses, liabilities, damages, costs and expenses
(including reasonable attorney’s fees and amounts paid in settlement in good faith) arising from or relating to any breach of the representations and warranties made by the Executive in this Section 5.4. 

  
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 Section 5.5. Notices. Any notice or other communication required or permitted
hereunder shall be in writing and shall be delivered personally or sent by nationally recognized overnight courier service (with next business day delivery requested). Any such notice or communication shall be deemed given and effective, in the case
of personal delivery, upon receipt by the other party, and in the case of a courier service, upon the next business day, after dispatch of the notice or communication. Any such notice or communication shall be addressed as follows: 

If to the Company, to: 

Regado Biosciences, Inc. 

120 Mountain View Boulevard 

Basking Ridge, NJ 07920 

Attn: Board of Directors 

With a copy to: 

Lowenstein Sandler LLP 

1251 Avenue of the Americas 

New York, New York 10020 

Attn: Michael J. Lerner, Esq. 

If to the Executive, to: 

Michael A. Metzger 

41 North Way 

Chappaqua, NY 10514 
 Any person
named above may designate another address by giving notice in accordance with this Section to the other persons named above. 

Section 5.6. Governing Law; Jurisdiction. This Agreement shall be governed by, and construed in accordance with, the laws of the
State of New Jersey, without regard to principles of conflicts of law. Any and all actions arising out of this Agreement or Employee’s employment by Company or termination therefrom shall be brought and heard in the state and federal courts of
the State of New Jersey and the parties hereto hereby irrevocably submit to the exclusive jurisdiction of any such courts. THE COMPANY AND THE EXECUTIVE HEREBY WAIVE THEIR RESPECTIVE RIGHT TO TRIAL BY JURY IN ANY ACTION CONCERNING THIS AGREEMENT OR
ANY AND ALL MATTERS ARISING DIRECTLY OR INDIRECTLY HEREFROM AND REPRESENT THAT THEY HAVE CONSULTED WITH COUNSEL OF THEIR CHOICE OR HAVE CHOSEN VOLUNTARILY NOT TO DO SO SPECIFICALLY WITH RESPECT TO THIS WAIVER. 

Section 5.7. Waiver. Either party hereto may waive compliance by the other party with any provision of this Agreement. The failure
of a party to insist on strict adherence to any term of this Agreement on any occasion shall not be considered a waiver or deprive that party of the right thereafter to insist upon strict adherence to that term or any other term of this Agreement.
No waiver of any provision shall be construed as a waiver of any other provision. Any waiver must be in writing. 

  
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 Section 5.8. Severability. If any one or more of the terms, provisions, covenants and
restrictions of this Agreement shall be determined by a court of competent jurisdiction to be invalid, void or unenforceable, the remainder of the terms, provisions, covenants and restrictions of this Agreement shall remain in full force and effect
and shall in no way be affected, impaired or invalidated and the parties will attempt to agree upon a valid and enforceable provision which shall be a reasonable substitute for such invalid and unenforceable provision in light of the tenor of this
Agreement, and, upon so agreeing, shall incorporate such substitute provision in this Agreement. In addition, if any one or more of the provisions contained in this Agreement shall for any reason be determined by a court of competent jurisdiction to
be excessively broad as to duration, geographical scope, activity or subject, it shall be construed, by limiting or reducing it, so as to be enforceable to the extent compatible with then applicable law. 

Section 5.9. Counterparts. This Agreement may be executed in any number of counterparts and each such duplicate counterpart shall
constitute an original, any one of which may be introduced in evidence or used for any other purpose without the production of its duplicate counterpart. Moreover, notwithstanding that any of the parties did not execute the same counterpart, each
counterpart shall be deemed for all purposes to be an original, and all such counterparts shall constitute one and the same instrument, binding on all of the parties hereto. 

Section 5.10. Advice of Counsel. Both parties hereto acknowledge that they have had the opportunity to seek and obtain the advice
of counsel before entering into this Agreement and have done so to the extent desired, and have fully read the Agreement and understand the meaning and import of all the terms hereof. 

Section 5.11. Assignment. This Agreement shall inure to the benefit of the Company and its successors and assigns (including,
without limitation, the purchaser of all or substantially all of its assets) and shall be binding upon the Company and its successors and assigns. This Agreement is personal to the Executive, and the Executive shall not assign or delegate his rights
or duties under this Agreement, and any such assignment or delegation shall be null and void. 
 Section 5.12. Agreement to Take
Actions. Each party to this Agreement shall execute and deliver such documents, certificates, agreements and other instruments, and shall take all other actions, as may be reasonably necessary or desirable in order to perform his or its
obligations under this Agreement. 
 Section 5.13. No Attachment. Except as required by law, no right to receive payments under
this Agreement shall be subject to anticipation, commutation, alienation, sale, assignment, encumbrance, charge, pledge, or hypothecation or to execution, attachment, levy or similar process or assignment by operation of law, and any attempt,
voluntary or involuntary, to effect any such action shall be null, void and of no effect; provided, however, that nothing in this Section 5.13 shall preclude the assumption of such rights by executors, administrators or
other legal representatives of the Executive or the Executive’s estate and their assigning any rights hereunder to the person or persons entitled thereto. 

  
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 Section 5.14. Source of Payment. Except as otherwise provided under the terms of any
applicable employee benefit plan, all payments provided for under this Agreement shall be paid in cash from the general funds of Company. The Company shall not be required to establish a special or separate fund or other segregation of assets to
assure such payments, and, if the Company shall make any investments to aid it in meeting its obligations hereunder, the Executive shall have no right, title or interest whatever in or to any such investments except as may otherwise be expressly
provided in a separate written instrument relating to such investments. Nothing contained in this Agreement, and no action taken pursuant to its provisions, shall create or be construed to create a trust of any kind, or a fiduciary relationship,
between Company and the Executive or any other person. To the extent that any person acquires a right to receive payments from Company hereunder, such right, without prejudice to rights which employees may have, shall be no greater than the right of
an unsecured creditor of Company. The Executive shall not look to the owners of the Company for the satisfaction of any obligations of the Company under this Agreement. 

Section 5.15. Tax Withholding. The Company or other payor is authorized to withhold from any benefit provided or payment due
hereunder, the amount of withholding taxes due any federal, state or local authority in respect of such benefit or payment and to take such other action as may be necessary in the opinion of the Board to satisfy all obligations for the payment of
such withholding taxes. The Executive will be solely responsible for all taxes assessed against him with respect to the compensation and benefits described in this Agreement, other than typical employer-paid taxes such as FICA, and the Company makes
no representations as to the tax treatment of such compensation and benefits. 
 Section 5.16. Mitigation of Damages. In no
event shall the Executive be obliged to seek other employment or take any other action by way of mitigation of the severance benefits payable to the Executive pursuant to Section 4.1 or Section 4.3 of the Agreement, nor shall the amount of
any such severance benefits be reduced by any compensation earned by the Executive in connection with the Executive’s employment by another employer. 

Section 5.17. 409A Compliance. All payments under this Agreement are intended to comply with or be exempt from the requirements of
Section 409A of the Code and regulations promulgated thereunder (“Section 409A”). As used in this Agreement, the “Code” means the Internal Revenue Code of 1986, as amended. To the extent permitted under
applicable regulations and/or other guidance of general applicability issued pursuant to Section 409A, the Company reserves the right to modify this Agreement to conform with any or all relevant provisions regarding compensation and/or benefits
so that such compensation and benefits are exempt from the provisions of 409A and/or otherwise comply with such provisions so as to avoid the tax consequences set forth in Section 409A and to assure that no payment or benefit shall be subject
to an “additional tax” under Section 409A. To the extent that any provision in this Agreement is ambiguous as to its compliance with Section 409A, or to the extent any provision in this Agreement must be modified to comply with
Section 409A, such provision shall be read in such a manner so that no payment due to the Executive shall be subject to an “additional tax” within the meaning of Section 409A(a)(1)(B) of the Code. If necessary to comply with the
restriction in Section 409A(a)(2)(B) of the Code concerning payments to “specified employees,” any payment on account of the Executive’s separation from service that would otherwise be due hereunder within six (6) months
after such separation shall be delayed 

  
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until the first business day of the seventh month following the Termination Date and the first such payment shall include the cumulative amount of any payments (without interest) that would have
been paid prior to such date if not for such restriction. Each payment in a series of payments hereunder shall be deemed to be a separate payment for purposes of Section 409A. In no event may the Executive, directly or indirectly, designate the
calendar year of payment. All reimbursements provided under this Agreement shall be made or provided in accordance with the requirements of Section 409A, including, where applicable, the requirement that (i) any reimbursement is for
expenses incurred during the Executive’s lifetime (or during a shorter period of time specified in this Agreement), (ii) the amount of expenses eligible for reimbursement during a calendar year may not affect the expenses eligible for
reimbursement in any other calendar year, (iii) the reimbursement of an eligible expense will be made on or before the last day of the calendar year following the year in which the expense is incurred, and (iv) the right to reimbursement
is not subject to liquidation or exchange for another benefit. Notwithstanding anything contained herein to the contrary, the Executive shall not be considered to have terminated employment with the Company for purposes of Section 4.1 or
4.3 unless the Executive would be considered to have incurred a “termination of employment” from the Company within the meaning of Treasury Regulation §1.409A-1(h)(1)(ii). In no event whatsoever shall the Company be liable for
any additional tax, interest or penalty that may be imposed on the Executive by Section 409A or damages for failing to comply with Section 409A. 

Section 5.18. 280G Modified Cutback. 

(a) If any payment, benefit or distribution of any type to or for the benefit of the Executive, whether paid or payable, provided or to be
provided, or distributed or distributable pursuant to the terms of this Agreement or otherwise (collectively, the “Parachute Payments”) would (i) constitute a “parachute payment” within the meaning of
Section 280G of the Code, and (ii) subject the Executive to the excise tax imposed under Section 4999 of the Code (the “Excise Tax”), the Parachute Payments shall be reduced so that the maximum amount of the Parachute
Payments (after reduction) shall be one dollar ($1.00) less than the amount which would cause the Parachute Payments to be subject to the Excise Tax; provided that the Parachute Payments shall only be reduced to the extent the after-tax value of
amounts received by the Executive after application of the above reduction would exceed the after-tax value of the amounts received without application of such reduction. For this purpose, the after-tax value of an amount shall be determined taking
into account all federal, state, and local income, employment and excise taxes applicable to such amount. Unless the Executive shall have given prior written notice to the Company to effectuate a reduction in the Parachute Payments if such a
reduction is required, which notice shall be consistent with the requirements of Section 409A to avoid the imputation of any tax, penalty or interest thereunder, then the Company shall reduce or eliminate the Parachute Payments by first
reducing or eliminating any cash payments (with the payments to be made furthest in the future being reduced first), then by reducing or eliminating accelerated vesting of stock options or similar awards, and then by reducing or eliminating any
other remaining Parachute Payments; provided, that no such reduction or elimination shall apply to any non-qualified deferred compensation amounts (within the meaning of Section 409A) to the extent such reduction or elimination would accelerate
or defer the timing of such payment in manner that does not comply with Section 409A. 

  
 -16- 

 (b) An initial determination as to whether (x) any of the Parachute Payments received by the
Executive in connection with the occurrence of a change in the ownership or control of the Company or in the ownership of a substantial portion of the assets of the Company shall be subject to the Excise Tax, and (y) the amount of any
reduction, if any, that may be required pursuant to the previous paragraph, shall be made by an independent accounting firm selected by the Company (the “Accounting Firm”) prior to the consummation of such change in the ownership or
effective control of the Company or in the ownership of a substantial portion of the assets of the Company. The Company will bear all expenses with respect to the determinations by such Accounting Firm required to be made hereunder. The Executive
shall be furnished with notice of all determinations made as to the Excise Tax payable with respect to the Executive’s Parachute Payments, together with the related calculations of the Accounting Firm, promptly after such determinations and
calculations have been received by the Company. 
 (c) For purposes of this Section 5.18, (i) no portion of the Parachute
Payments the receipt or enjoyment of which the Executive shall have effectively waived in writing prior to the date of payment of the Parachute Payments shall be taken into account; (ii) no portion of the Parachute Payments shall be taken into
account which in the opinion of the Accounting Firm does not constitute a “parachute payment” within the meaning of Section 280G(b)(2) of the Code; (iii) the Parachute Payments shall be reduced only to the extent necessary so
that the Parachute Payments (other than those referred to in the immediately preceding clause (i) or (ii)) in their entirety constitute reasonable compensation for services actually rendered within the meaning of Section 280G(b)(4) of the
Code or are otherwise not subject to disallowance as deductions, in the opinion of the auditor or tax counsel referred to in such clause (ii); and (iv) the value of any non-cash benefit or any deferred payment or benefit included in the
Parachute Payments shall be determined by the Company’s independent auditors based on Sections 280G and 4999 of the Code and the regulations for applying those sections of the Code, or on substantial authority within the meaning of
Section 6662 of the Code. 
 [Signature Page Follows] 

  
 -17- 

 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the day and year
first above written. 
  

			
	 COMPANY
  

Regado Biosciences, Inc.

		
	By:	 	/s/ David J. Mazzo, Ph.D.
	Name:	 	David J. Mazzo, Ph.D.
	Title:	 	Chief Executive Officer

  

			
	EXECUTIVE
	
	/s/ Michael A. Metzger
	Michael A. Metzger

 [SIGNATURE PAGE TO EMPLOYMENT
AGREEMENT] 

 SCHEDULE A 

Proprietary Information, Inventions, and Noncompetition Agreement 

  
 -19-

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