Document:

Exhibit 10.1

 

REGISTRATION RIGHTS AGREEMENT

 

BY AND BETWEEN

 

CRYOPORT, INC.

 

AND

 

BLACKSTONE FREEZE PARENT L.P.

 

Dated as of October 1, 2020

 

     

     

    

 

TABLE OF CONTENTS

 

Page

 

	Article I Resale Shelf Registration	1
	Section 1.1   Resale Shelf Registration Statement	1
	Section 1.2   Effectiveness Period	2
	Section 1.3   Subsequent Shelf Registration	2
	Section 1.4   Supplements and Amendments	3
	Section 1.5   Subsequent Holder Notice	3
	Section 1.6   Underwritten Offering	3
	Section 1.7   Take-Down Notice	4
	Article II Company Registration	4
	Section 2.1   Notice of Registration	4
	Section 2.2   Underwriting	5
	Section 2.3   Right to Terminate Registration	5
	Article III Additional Provisions Regarding Registration Rights	5
	Section 3.1   Registration Procedures	5
	Section 3.2   Limitation on Subsequent Registration Rights	8
	Section 3.3   Expenses of Registration	8
	Section 3.4   Information by Holders	8
	Section 3.5   Rule 144 Reporting	9
	Section 3.6   “Market Stand-Off” Agreement	9
	Article IV Indemnification	10
	Section 4.1   Indemnification by Company	10
	Section 4.2   Indemnification by Holders	11
	Section 4.3   Notification	11
	Section 4.4   Contribution	12
	Article V Transfer and Termination of Registration Rights	13
	Section 5.1   Transfer of Registration Rights	13
	Section 5.2   Termination of Registration Rights	13
	Article VI Miscellaneous	13
	Section 6.1   Counterparts	13
	Section 6.2   Governing Law.	13
	Section 6.3   Entire Agreement; No Third Party Beneficiary	14
	Section 6.4   Expenses	14
	Section 6.5   Notices	14

 

 

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	Section 6.6   Successors and Assigns	15
	Section 6.7   Headings	15
	Section 6.8   Amendments and Waivers	16
	Section 6.9   Interpretation; Absence of Presumption	16
	Section 6.10   Severability	16

 

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REGISTRATION RIGHTS AGREEMENT

 

This REGISTRATION RIGHTS
AGREEMENT (this “Agreement”) is entered into as of October 1, 2020, by and between Cryoport, Inc., a Nevada
corporation (including its successors and permitted assigns, the “Company”), and Blackstone Freeze Parent L.P.,
a Delaware limited partnership (the “Investor”). Capitalized terms used but not defined elsewhere herein are
defined in Exhibit A.

 

This Agreement is entered
into in connection with the closing of the issuance of 250,000 shares of the Series C Convertible Preferred Stock, which are convertible
into shares of Common Stock, and 675,536 shares of Common Securities Pursuant to the Securities Purchase Agreement, dated as of
August 24, 2020, by and between the Company and the Investor (the “Securities Purchase Agreement”).

 

As a condition to each
of the parties’ obligations under the Securities Purchase Agreement, the Company and the Investor are entering into this
Agreement for the purpose of granting certain registration rights to the Investor.

 

In consideration of
the premises and the mutual representations, warranties, covenants and agreements contained herein, and for other good and valuable
consideration, the receipt and sufficiency of which is hereby acknowledged, the parties agree as follows:

 

Article
I

Resale Shelf Registration

 

Section 1.1           
Resale Shelf Registration Statement. Subject to the other applicable provisions of this Agreement, the Company shall
file within ninety (90) days of the date hereof and use its commercially reasonable efforts to cause to go effective as promptly
as practicable a registration statement covering the sale or distribution from time to time by the Holders, on a delayed or continuous
basis pursuant to Rule 415 of the Securities Act of all of the Registrable Securities on Form S-3 (except if the Company is not
then eligible to register for resale the Registrable Securities on Form S-3, then such registration shall be on another appropriate
form (including Form S-1) and shall provide for the registration of such Registrable Securities for resale by such Holders in accordance
with any reasonable method of distribution elected by the Holders) (the “Resale Shelf Registration Statement”
and such registration, the “Resale Shelf Registration”), and if the Company is a WKSI as of the filing date,
the Resale Shelf Registration Statement shall be an Automatic Shelf Registration Statement. If the Resale Shelf Registration Statement
is not an Automatic Shelf Registration Statement, then the Company shall use its commercially reasonable efforts to cause such
Resale Shelf Registration Statement to be declared effective by the Commission as promptly as practicable after the filing thereof.

 

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Notwithstanding
the foregoing, if the Commission prevents the Company from including any or all of the Registrable Securities on the Resale
Shelf Registration Statement due to limitations on the use of Rule 415 of the Securities Act for the resale of the
Registrable Securities by the Holders (a “Rule 415 Limitation”), the Resale Shelf Registration Statement
shall register the resale of a number of shares of the Registrable Securities which is equal to the maximum number of shares
as is permitted by the Commission, and, subject to the provisions of this Section 1.1, the Company shall continue to
its use commercially reasonable efforts to register all remaining Registrable Securities as set forth in this Section
1.1. In such event, the number of shares of Registrable Securities to be registered for each Holder in the Resale Shelf
Registration Statement shall be reduced pro rata among all Holders, provided, however, that, prior to reducing
the number of shares of Registrable Securities to be registered for any Holder in such Resale Shelf Registration Statement,
the Company shall first remove any shares of Registrable Securities to be registered for any Person other than a Holder that
was proposed to be included in such Resale Shelf Registration Statement. The Company shall continue to use its commercially
reasonable efforts to register all remaining Registrable Securities as promptly as practicable in accordance with the
applicable rules, regulations and guidance of the Commission. Notwithstanding anything herein to the contrary, if the
Commission, by written comment, limits the Company’s ability to file, or prohibits or delays the filing of, a Resale
Shelf Registration Statement or a Subsequent Shelf Registration with respect to any or all the Registrable Securities, the
Company’s compliance with such limitation, prohibition or delay solely to the extent of such limitation, prohibition or
delay shall not be a breach or default by the Company under this Agreement and shall not be deemed a failure by the Company
to use “commercially reasonable efforts” or “reasonable efforts” as set forth above or elsewhere in
this Agreement.

 

Section 1.2           
Effectiveness Period. Once effective, the Company shall, subject to the other applicable provisions of this Agreement,
use its commercially reasonable efforts to cause the Resale Shelf Registration Statement or a Subsequent Shelf Registration to
be continuously effective and usable for so long as any Registrable Securities remain outstanding (the “Effectiveness
Period”).

 

Section 1.3            Subsequent
Shelf Registration. If any Shelf Registration ceases to be effective under the Securities Act for any reason at any time
during the Effectiveness Period, the Company shall use its commercially reasonable efforts to promptly cause such Shelf
Registration to again become effective under the Securities Act (including obtaining the prompt withdrawal of any order
suspending the effectiveness of such Shelf Registration), and in any event shall within thirty (30) days of such cessation of
effectiveness, amend such Shelf Registration in a manner reasonably expected to obtain the withdrawal of any order suspending
the effectiveness of such Shelf Registration or, file an additional registration statement (a “Subsequent Shelf
Registration”) for an offering to be made on a delayed or continuous basis pursuant to Rule 415 of the Securities
Act registering the resale from time to time by Holders thereof of all securities that are Registrable Securities as of the
time of such filing. If a Subsequent Shelf Registration is filed, the Company shall use its commercially reasonable efforts
to (a) cause such Subsequent Shelf Registration to become effective under the Securities Act as promptly as is reasonably
practicable after such filing, but in no event later than the date that is ninety (90) days after such Subsequent Shelf
Registration is filed and (b) keep such Subsequent Shelf Registration (or another Subsequent Shelf Registration)
continuously effective until the end of the Effectiveness Period. Any such Subsequent Shelf Registration shall be a
Registration Statement on Form S-3 to the extent that the Company is eligible to use such form, and if the Company is a WKSI
as of the filing date, such Registration Statement shall be an Automatic Shelf Registration Statement. Otherwise, such
Subsequent Shelf Registration shall be on another appropriate form (including Form S-1) and shall provide for the
registration of such Registrable Securities for resale by such Holders in accordance with any reasonable method of
distribution elected by the Holders.

 

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Section 1.4           
Supplements and Amendments. The Company shall supplement and amend any Shelf Registration if required by the rules,
regulations or instructions applicable to the registration form used by the Company for such Shelf Registration if required by
the Securities Act or as reasonably requested by the Holders covered by such Shelf Registration.

 

Section 1.5           
Subsequent Holder Notice. If a Person becomes a Holder of Registrable Securities after a Shelf Registration becomes
effective under the Securities Act, the Company shall, as promptly as is reasonably practicable following delivery of written notice
to the Company of such Person becoming a Holder and requesting for its name to be included as a selling securityholder in the prospectus
related to the Shelf Registration (a “Subsequent Holder Notice”):

 

(a)              
if required and permitted by applicable law, file with the Commission a supplement to the related prospectus or a post-effective
amendment to the Shelf Registration so that such Holder is named as a selling securityholder in the Shelf Registration and the
related prospectus in such a manner as to permit such Holder to deliver a prospectus to purchasers of the Registrable Securities
in accordance with applicable law;

 

(b)              
if, pursuant to Section 1.5(a), the Company shall have filed a post-effective amendment to the Shelf Registration
that is not automatically effective, use its commercially reasonable efforts to cause such post-effective amendment to become effective
under the Securities Act as promptly as is reasonably practicable, but in any event by the date that is ninety (90) days after
the date such post-effective amendment is required by Section 1.5(a) to be filed; and

 

(c)              
notify such Holder as promptly as is reasonably practicable after the effectiveness under the Securities Act of any post-effective
amendment filed pursuant to Section 1.5(a).

 

Section 1.6           
Underwritten Offering. The Holders of Registrable Securities may on up to four (4) occasions after the Resale Shelf
Registration Statement becomes effective deliver a written notice to the Company specifying that the sale of some or all of the
Registrable Securities subject to the Shelf Registration is intended to be conducted through an underwritten offering, so long
as the anticipated gross proceeds of such underwritten offering is not less than thirty-five million dollars ($35,000,000) (unless
the Holders are proposing to sell all of their remaining Registrable Securities in which case no such minimum gross proceeds threshold
shall apply) (the “Underwritten Offering”). In the event of an Underwritten Offering:

 

(a)              
The Holder or Holders of a majority of the Registrable Securities participating in an Underwritten Offering shall select
the managing underwriter or underwriters to administer the Underwritten Offering; provided that such Holder or Holders will not
make the choice of such managing underwriter or underwriters without first consulting with the Company.

 

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(b)              
 Notwithstanding any other provision of this Section 1.6, if the managing underwriter or underwriters of a proposed
Underwritten Offering advises the Board of Directors of the Company that in its or their opinion the number of Registrable Securities
requested to be included in such Underwritten Offering exceeds the number which can be sold in such Underwritten Offering in light
of market conditions, the Registrable Securities shall be included on a pro rata basis upon the number of securities that each
Holder shall have requested to be included in such offering. If any Holder disapproves of the terms of any such underwriting, such
Holder may elect to withdraw therefrom by written notice to the Company and the managing underwriter or underwriters.

 

(c)              
The Company shall agree and shall cause its executive officers and directors to sign a customary “lock-up” agreement
with the underwriters in any Underwritten Offering.

 

Section 1.7           
Take-Down Notice. Subject to the other applicable provisions of this Agreement, at any time that any Shelf Registration
Statement is effective, if a Holder delivers a notice to the Company (a “Take-Down Notice”) stating that it
intends to effect a sale or distribution of all or part of its Registrable Securities included by it on any Shelf Registration
Statement (a “Shelf Offering”) and stating the number of Registrable Securities to be included in such Shelf
Offering, then, subject to the other applicable provisions of this Agreement, the Company shall, as promptly as practicable, amend
or supplement the Shelf Registration Statement as may be necessary in order to enable such Registrable Securities to be sold and
distributed pursuant to the Shelf Offering.

 

Article
II

Company Registration

 

Section 2.1           
Notice of Registration. If at any time or from time to time the Company shall determine to file a registration statement
with respect to an offering (or to make an underwritten public offering pursuant to a previously filed registration statement)
of its Common Stock, whether or not for its own account (other than a registration statement on Form S-4, Form S-8 or any successor
forms), the Company will:

 

(a)              
promptly give to each Holder written notice thereof, which notice shall be given, to the extent reasonably practicable,
no later than five (5) business days prior to the filing or launch date (except in the case of an offering that is an “overnight
offering”, in which case such notice must be given no later than two (2) business days prior to the filing or launch date);
and

 

(b)              
subject to Section 2.2, include in such registration or underwritten offering (and any related qualification under
blue sky laws or other compliance) all the Registrable Securities specified in a written request or requests made within three
(3) business days after receipt of such written notice from the Company by any Holder (except in the case of an offering that is
an “overnight offering”, in which case such request must be made no later than one (1) business day after receipt of
such written notice from the Company).

 

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Section 2.2            Underwriting.
The right of any Holder to registration pursuant to Section 1.6 or this Article II shall be conditioned
upon such Holder’s participation in such underwriting and the inclusion of Registrable Securities in the underwriting
to the extent provided herein. Each Holder proposing to distribute its securities through such underwriting shall (together
with the Company and the other holders distributing their securities through such underwriting) enter into and perform such
Holder’s obligations under an underwriting agreement with the managing underwriter selected for such underwriting by
the Company or by the stockholders of the Company who have the right to select the underwriters (such underwriting agreement
to be in a customary form negotiated by the Company or such stockholders, as the case may be). Notwithstanding any other
provision of this Article II, if the managing underwriter or underwriters of a proposed underwritten offering with
respect to which Holders of Registrable Securities have exercised their piggyback registration rights advise the Board of
Directors of the Company that in its or their opinion the number of Registrable Securities requested to be included in the
offering thereby and all other securities proposed to be sold in the offering exceeds the number which can be sold in such
underwritten offering in light of market conditions, the Registrable Securities and such other securities to be included in
such underwritten offering shall be allocated, (a) first, in the event such offering was initiated by the Company for its own
account, up to the total number of securities that the Company has requested to be included in such registration, (b) second,
and only if all the securities referred to in clause (a) have been included, up to the total number of securities that the
Holders have requested to be included in such offering (pro rata based upon the number of securities that each of them shall
have requested to be included in such offering) and (c) third, and only if all the securities referred to in clause (b) have
been included, all other securities proposed to be included in such offering that, in the opinion of the managing underwriter
or underwriters can be sold without having such adverse effect. If any Holder disapproves of the terms of any such
underwriting, such Holder may elect to withdraw therefrom by written notice to the Company and the managing underwriter or
underwriters. Any securities excluded or withdrawn from such underwriting shall be withdrawn from such registration.

 

Section 2.3           
Right to Terminate Registration. The Company or the holders of securities who have caused a registration statement
to be filed as contemplated by this Article II, as the case may be, shall have the right to have any registration initiated
by it or them under this Article II terminated or withdrawn prior to the effectiveness thereof, whether or not any Holder
has elected to include securities in such registration.

 

Article
III

Additional Provisions Regarding Registration Rights

 

Section 3.1           
Registration Procedures. In the case of each registration effected by the Company pursuant to Article I or
II, the Company will keep each Holder participating in such registration reasonably informed as to the status thereof and,
at its expense, the Company will, as expeditiously as possible to the extent applicable:

 

(a)              
prepare and file, as promptly as reasonably practicable, with the Commission a registration statement with respect to such
securities in accordance with the applicable provisions of this Agreement;

 

(b)               prepare
and file, as promptly as reasonably practicable, with the Commission such amendments, including post-effective amendments,
and supplements to such registration statement and the prospectus used in connection with such registration statement as may
be necessary to comply with the provisions of the Securities Act with respect to the disposition of all securities covered by
such registration statement (including to permit the intended method of distribution thereof) and as may be necessary to keep
the registration statement continuously effective for the period set forth in this Agreement;

 

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(c)              
furnish to the Holders participating in such registration and to their legal counsel copies of the registration statement
proposed to be filed, and provide such Holders and their legal counsel the reasonable opportunity to review and comment on such
registration statement;

 

(d)              
furnish to the Holders participating in such registration and to the underwriters of the securities being registered such
reasonable number of copies of the registration statement, preliminary prospectus and final prospectus as the such underwriters
may reasonably request in order to facilitate the public offering of such securities;

 

(e)              
use commercially reasonable efforts to notify each Holder of Registrable Securities covered by such registration statement
at any time when a prospectus relating thereto is required to be delivered under the Securities Act of the Company’s knowledge
of the happening of any event as a result of which the prospectus included in such registration statement, as then in effect, includes
an untrue statement of a material fact or omits to state a material fact required to be stated therein or necessary to make the
statements therein not misleading or incomplete in the light of the circumstances then existing, and, subject to Section 3.1(n),
at the request of any such Holder, prepare promptly and furnish to such Holder a reasonable number of copies of a supplement to
or an amendment of such prospectus as may be necessary so that, as thereafter delivered to the purchaser of such shares, such prospectus
shall not include an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary
to make the statements therein not misleading or incomplete in the light of the circumstances then existing;

 

(f)               
use commercially reasonable efforts to register and qualify the securities covered by such registration statement under
such other securities or blue sky laws of such jurisdictions as shall be reasonably requested by the Holders; provided,
however, that the Company shall not be required in connection therewith or as a condition thereto to qualify to do business
or to file a general consent to service of process in any such states or jurisdictions in which it is not already qualified;

 

(g)              
in the event that the Registrable Securities are being offered in an underwritten public offering, enter into and perform
its obligations under an underwriting agreement on customary terms and in accordance with the applicable provisions of this Agreement;

 

(h)               use
commercially reasonable efforts to furnish, (i) on the date that such Registrable Securities are delivered to the
underwriters for sale, if such securities are being sold through underwriters, an opinion and negative assurance letter,
dated as of such date, of the legal counsel representing the Company for the purposes of such registration, in form and
substance as is customarily given to underwriters in an underwritten public offering, addressed to the underwriters, if any,
and (ii) on the date that the offering of such Registrable Securities is priced and on the date that such securities are
being sold through underwriters, a letter dated as of such date, from the independent certified public accountants of the
Company, in form and substance as is customarily given by independent certified public accountants to underwriters in an
underwritten public offering, addressed to the underwriters;

 

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(i)                
in connection with a customary due diligence review, make available during business hours for inspection by the Holders,
any underwriter participating in any such disposition of Registrable Securities, if any, and any counsel or accountants retained
by the Holders or underwriter (collectively, the “Offering Persons”), all relevant financial and other records,
pertinent corporate documents and properties of the Company and its subsidiaries, and cause the officers, directors and employees
of the Company and its subsidiaries to supply all relevant information and participate in customary due diligence sessions in each
case reasonably requested by any such representative, underwriter, counsel or accountant in connection with such registration statement,
provided, however, each such underwriter shall agree in writing to hold in strict confidence and not to make any disclosure or
use of any information requested above (the “Requested Information”), unless (1) the disclosure of the Requested
Information is necessary to avoid or correct a misstatement or omission in such registration or is otherwise required under the
Securities Act, (2) the release of the Requested Information is ordered pursuant to a final, non-appealable subpoena or order from
a court or government body of competent jurisdiction, (3) the Requested Information is or has been made generally available to
the public other than by disclosure in violation of this Agreement, (4) the Requested Information was within such underwriter’s
possession on a non-confidential basis prior to it being furnished to such underwriter by or on behalf of the Company or any of
its representatives, provided that the source of such information was not bound by a confidentiality agreement or other contractual,
legal or fiduciary obligation of confidentiality with respect to such information or (5) the Requested Information becomes available
to such underwriter on a non-confidential basis from a source other than the Company or any of its representatives, provided that
such source is not bound by a confidentiality agreement or other contractual, legal or fiduciary obligation of confidentiality
with respect to such information. Such underwriter agrees that it shall, upon learning that disclosure of the Requested Information
is sought in or by a court or governmental body of competent jurisdiction or through other means, give prompt notice to the Company
and allow the Company, at the Company’s expense, to undertake appropriate action to prevent disclosure of, or to obtain a
protective order for, the Requested Information deemed confidential;

 

(j)                
in the event that any broker-dealer underwrites any Registrable Securities or participates as a member of an underwriting
syndicate or selling group or “participates in an offering” (within the meaning of the FINRA Rules) thereof, whether
as a Holder or as an underwriter, placement, sales agent or broker or dealer in respect thereof, or otherwise, the Company will,
upon the reasonable request of such broker-dealer, comply with any reasonable request of such broker-dealer in complying with the
FINRA Rules;

 

(k)               notwithstanding
any other provision of this Agreement, if the Board of Directors of the Company has determined in good faith that the
disclosure necessary for continued use of the prospectus and registration statement by the Holders could be materially
detrimental to the Company, the Company shall have the right not to file or not to cause the effectiveness of any
registration covering any Registrable Securities and to suspend the use of the prospectus and the registration statement
covering any Registrable Security for such period of time as its use would be materially detrimental to the Company by
delivering written notice of such suspension to all Holders listed on the Company’s records; provided, however,
that in any 12-month period the Company may exercise the right to such suspension not more than twice. From and after the
date of a notice of suspension under this Section 3.1(k), each Holder agrees not to use the prospectus or registration
statement until the earlier of (i) notice from the Company that such suspension has been lifted or (ii) the day following the
sixtieth (60th) day of suspension within any 12-month period;

 

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(l)                
cooperate with, and direct the Company’s transfer agent to cooperate with, the Holders and the managing underwriters,
if any, to facilitate the timely settlement of any offering or sale of Registrable Securities, including the preparation and delivery
of certificates or book-entry representing Registrable Securities to be sold together with any other authorizations, certificates,
opinions and directions required by the transfer agent which authorize and direct the transfer agent to issue such Registrable
Securities without restriction upon sale by the holder of such shares of Registrable Securities;

 

(m)             
use its reasonable best efforts to cause all shares of Registrable Securities to be listed on the national securities exchange
on which the Common Stock is then listed; and

 

(n)              
cause its officers to use their reasonable best efforts to support the marketing of the Registrable Securities (including,
without limitation, participation in “road shows” and other customary marketing activities, which may be virtual).

 

Section 3.2           
Limitation on Subsequent Registration Rights. From and after the date hereof, the Company shall not enter into any
agreement granting any holder or prospective holder of any securities of the Company registration rights with respect to such securities
that conflict with the rights granted to the Holders herein, without the prior written consent of Holders of a majority of the
Registrable Securities.

 

Section 3.3           
Expenses of Registration. All Registration Expenses incurred in connection with any registration pursuant to this
Agreement or otherwise in complying with this Agreement shall be borne by the Company. All Selling Expenses relating to securities
registered on behalf of the Holders shall be borne by the Holders of the registered securities included in such registration.

 

Section 3.4           
Information by Holders. The Holder or Holders of Registrable Securities included in any registration shall furnish
to the Company such information regarding such Holder or Holders, the Registrable Securities held by them and the distribution
proposed by such Holder or Holders as the Company may reasonably request in writing and as shall be required in connection with
any registration, qualification or compliance referred to in this Agreement. It is understood and agreed that the obligations of
the Company under Article I or II are conditioned on the timely provisions of the foregoing information by such Holder
or Holders and, without limitation of the foregoing, will be conditioned on compliance by such Holder or Holders with the following:

 

(a)               such
Holder or Holders will cooperate with the Company in connection with the preparation of the applicable registration
statement, and for so long as the Company is obligated to keep such registration statement effective, such Holder or Holders
will provide to the Company, in writing and in a timely manner, for use in such registration statement (and expressly
identified in writing as such), all information regarding themselves and such other information as may be required by
applicable law to enable the Company to prepare such registration statement and the related prospectus covering the
applicable Registrable Securities owned by such Holder or Holders and to maintain the currency and effectiveness thereof;

 

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(b)              
during such time as such Holder or Holders may be engaged in a distribution of the Registrable Securities, such Holder or
Holders will comply with all laws applicable to such distribution, including Regulation M promulgated under the Exchange Act, and,
to the extent required by such laws, will, among other things: (i) not engage in any stabilization activity in connection with
the securities of the Company in contravention of such laws and (ii) if required by applicable law, cause to be furnished to each
agent or broker-dealer to or through whom such Registrable Securities may be offered, or to the offeree if an offer is made directly
by such Holder or Holders, such copies of the applicable prospectus (as amended and supplemented to such date) and documents incorporated
by reference therein as may be required by such agent, broker-dealer or offeree; and

 

(c)              
on receipt of written notice from the Company of the happening of any of the events specified in Section 3.1(k),
or that requires the suspension by such Holder or Holders of the distribution of any of the Registrable Securities owned by such
Holder or Holders pursuant to a registered offering, then such Holders shall cease offering or distributing the Registrable Securities
owned by such Holder or Holders in a registered offering until the offering and distribution of the Registrable Securities owned
by such Holder or Holders may recommence in accordance with the terms hereof and applicable law.

 

Section 3.5           
Rule 144 Reporting. With a view to making available the benefits of Rule 144 to the Holders, the Company agrees that
it will file with the Commission the “Form 10 information” required by Rule 144(i)(2) as soon as practical after the
date of this Agreement and, for so long as a Holder owns Registrable Securities, the Company will use commercially reasonable efforts
to:

 

(a)              
file with the Commission in a timely manner all reports and other documents required of the Company under the Exchange Act;
and

 

(b)              
so long as a Holder owns any Restricted Securities, furnish to the Holder forthwith upon written request a written statement
by the Company as to its compliance with the reporting requirements of the Exchange Act.

 

Section 3.6            “Market
Stand-Off” Agreement. The Holders shall not sell, transfer, make any short sale of, grant any option for the
purchase of, or enter into any hedging or similar transaction with the same economic effect as a sale with respect to, any
Common Stock (or other securities of the Company) held by the Holders (other than those included in the registration) for a
period specified by the representatives of the managing underwriter or underwriters of Common Stock (or other securities of
the Company convertible into Common Stock) not to exceed five (5) days prior and ninety (90) days following any registered
public sale of securities by the Company in which such Holder participates in accordance with Article II, subject to
customary exceptions (including, without limitation, to the extent that any securities of the Company are subject to a
Permitted Loan (as defined in the Securities Purchase Agreement), to permit the pledge of such securities pursuant to such
Permitted Loan and any foreclosure in connection with such Permitted Loan, or transfer in lieu of a foreclosure thereunder,
and subsequent sales, dispositions or other transfers). Each of the Holders also shall execute and deliver any
 “lock-up” agreement reasonably requested by the representatives of any underwriters of the Company in connection
with an offering in which such Holder participates, subject to customary exceptions (including, without limitation, as
described in the preceding sentence in respect of a Permitted Loan).

 

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Article
IV

Indemnification

 

Section 4.1            Indemnification
by Company. To the extent permitted by applicable law, the Company will, with respect to any Registrable Securities as to
which registration or qualification or compliance under applicable “blue sky” laws has been effected pursuant to
this Agreement, indemnify each Holder, each Holder’s current and former officers, directors, partners, members,
managers, shareholders, accountants, attorneys, agents and employees, and each Person controlling such Holder or any of the
foregoing within the meaning of Section 15 of the Securities Act, and each underwriter thereof, if any, and each Person who
controls any such underwriter within the meaning of Section 15 of the Securities Act (collectively, the “Company
Indemnified Parties”), against all expenses, claims, losses, damages, costs (including costs of preparation and
reasonable attorney’s fees and any legal or other fees or expenses actually incurred by such party in connection with
any investigation or proceeding), judgments, fines, penalties, charges, amounts paid in settlement and other liabilities,
joint or several (or actions in respect thereof) arising out of or based on any untrue statement (or alleged untrue
statement) of a material fact contained in any registration statement, prospectus, preliminary prospectus, offering circular
or other document, or any amendment or supplement thereto incident to any such registration, qualification or compliance or
based on any omission (or alleged omission) to state therein a material fact required to be stated therein or necessary to
make the statements therein, in light of the circumstances in which they were made, not misleading, or any violation by the
Company of, or any rule or regulation promulgated under, the Securities Act, Exchange Act or state securities laws applicable
to the Company in connection with any such registration, and the Company will reimburse each of the Company Indemnified
Parties for any reasonable legal and any other expenses reasonably incurred in connection with investigating, preparing or
defending any such claim, loss, damage, liability or action, as such expenses are incurred. The indemnity agreement contained
in this Section 4.1 shall not apply to amounts paid in settlement of any loss, claim, damage, liability or action if
such settlement is effected without the prior written consent of the Company (which consent shall not be unreasonably
withheld or delayed), nor shall the Company be liable to a Holder in any such case for any such loss, claim, damage,
liability or action (a) to the extent that it arises out of or is based upon a violation or alleged violation of any state or
federal law (including any claim arising out of or based on any untrue statement or alleged untrue statement or omission or
alleged omission in the registration statement or prospectus) which occurs in reliance upon and in conformity with written
information furnished expressly for use in connection with such registration by or on behalf of any Holder or (b) in the case
of a sale directly by a Holder of Registrable Securities (including a sale of such Registrable Securities through any
underwriter retained by such Holder engaging in a distribution solely on behalf of such Holder), such untrue statement or
alleged untrue statement or omission or alleged omission was corrected in a final or amended prospectus, and such Holder
failed to deliver a copy of the final or amended prospectus at or prior to the confirmation of the sale of the Registrable
Securities to the Person asserting any such loss, claim, damage or liability in any case in which such delivery is required
by the Securities Act.

 

    10 

     

    

 

 

 

Section 4.2           
Indemnification by Holders. To the extent permitted by applicable law, each Holder will, if Registrable Securities
held by such Holder are included in the securities as to which such registration or qualification or compliance under applicable
 “blue sky” laws is being effected, indemnify, severally and not jointly, the Company, each of its directors, officers,
partners, members, managers, shareholders, accountants, attorneys, agents and employees, each underwriter, if any, of the Company’s
securities covered by such a registration, each Person who controls the Company or such underwriter within the meaning of Section
15 of the Securities Act, and each other Holder and each of such other Holder’s officers, directors, partners, members, managers,
shareholders, accountants, attorneys, agents and employees and each Person controlling such Holder or any of the foregoing within
the meaning of Section 15 of the Securities Act (collectively, the “Holder Indemnified Parties”), against all
expenses, claims, losses, damages, costs (including costs of preparation and reasonable attorney’s fees and any legal or
other fees or expenses actually incurred by such party in connection with any investigation or proceeding), judgments, fines, penalties,
charges, amounts paid in settlement and other and liabilities (or actions in respect thereof) arising out of or based on any untrue
statement (or alleged untrue statement) of a material fact contained in any registration statement, prospectus, preliminary prospectus,
offering circular or other document, or any amendment or supplement thereto incident to any such registration, qualification or
compliance or based on any omission (or alleged omission) to state therein a material fact required to be stated therein or necessary
to make the statements therein, in light of the circumstances in which they were made, not misleading, or any violation by such
Holder of, or any rule or regulation promulgated under, the Securities Act, Exchange Act or state securities law applicable to
such Holder, and will reimburse each of the Holder Indemnified Parties for any reasonable legal or any other expenses reasonably
incurred in connection with investigating, preparing or defending any such claim, loss, damage, liability or action, as such expenses
are incurred, in each case to the extent, but only to the extent, that such untrue statement (or alleged untrue statement) or omission
(or alleged omission) is made in such registration statement, prospectus, offering circular or other document in reliance upon
and in conformity with written information furnished to the Company by such Holder and stated to be specifically for use therein,
provided, however, that in no event shall any indemnity under this Section 4.2 payable by a Holder
exceed the amount by which the net proceeds actually received by such Holder from the sale of Registrable Securities included in
such registration exceeds the amount of any other losses, expenses, settlements, damages, claims and liabilities that such Holder
has been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission or violation. The
indemnity agreement contained in this Section 4.2 shall not apply to amounts paid in settlement of any loss, claim, damage,
liability or action if such settlement is effected without the prior written consent of the applicable Holder (which consent shall
not be unreasonably withheld or delayed), nor shall the Holder be liable for any such loss, claim, damage, liability or action
where such untrue statement or alleged untrue statement or omission or alleged omission was corrected in a final or amended prospectus,
and the Company or the underwriters failed to deliver a copy of the final or amended prospectus at or prior to the confirmation
of the sale of the Registrable Securities to the Person asserting any such loss, claim, damage or liability in any case in which
such delivery is required by the Securities Act

 

Section 4.3           Notification. Each party entitled to indemnification under this Article IV (the “Indemnified Party”)
shall give notice to the party required to provide indemnification (the “Indemnifying Party”) promptly after
such Indemnified Party has actual knowledge of any claim as to which indemnity may be sought, and shall permit the Indemnifying
Party to assume the defense of any such claim or any litigation resulting therefrom, provided, however, that counsel
for the Indemnifying Party, who shall conduct the defense of such claim or litigation, shall be approved by the Indemnified Party
(whose approval shall not unreasonably be withheld or delayed), and the Indemnified Party may participate in such defense at such
party’s expense; provided, further, however, that an Indemnified Party (together with all other Indemnified
Parties) shall have the right to retain one (1) separate counsel, with the reasonable fees and expenses to be paid by the Indemnifying
Party, if representation of such Indemnified Party by the counsel retained by the Indemnifying Party would be inappropriate due
to conflicting interests between such Indemnified Party and any other party represented by such counsel in such proceeding. The
failure of any Indemnified Party to give notice as provided herein shall relieve the Indemnifying Party of its obligations under
this Article IV, only to the extent that, the failure to give such notice is materially prejudicial or harmful to an Indemnifying
Party’s ability to defend such action. No Indemnifying Party, in the defense of any such claim or litigation, shall, except
with the prior written consent of each Indemnified Party (which consent shall not be unreasonably withheld or delayed), consent
to entry of any judgment or enter into any settlement which does not include as an unconditional term thereof the giving by the
claimant or plaintiff to such Indemnified Party of a release from all liability in respect to such claim or litigation. The indemnity
agreements contained in this Article IV shall not apply to amounts paid in settlement of any loss, claim, damage, liability
or action if such settlement is effected without the prior written consent of the Indemnifying Party, which consent shall not
be unreasonably withheld or delayed. The indemnification set forth in this Article IV shall be in addition to any other
indemnification rights or agreements that an Indemnified Party may have.

 

    11

     

    

 

Section 4.4            Contribution.
If the indemnification provided for in this Article IV is held by a court of competent jurisdiction to be unavailable
to an Indemnified Party, other than pursuant to its terms, with respect to any claim, loss, damage, liability or action
referred to therein, then, subject to the limitations contained in Article IV, the Indemnifying Party, in lieu of
indemnifying such Indemnified Party hereunder, shall contribute to the amount paid or payable by such Indemnified Party as a
result of such claim, loss, damage, liability or action in such proportion as is appropriate to reflect the relative fault of
the Indemnifying Party on the one hand and the Indemnified Party on the other in connection with the actions that resulted in
such claims, loss, damage, liability or action, as well as any other relevant equitable considerations. The relative fault of
the Indemnifying Party and of the Indemnified Party shall be determined by reference to, among other things, whether the
untrue or alleged untrue statement of a material fact or the omission to state a material fact related to information
supplied by the Indemnifying Party or by the Indemnified Party and the parties’ relative intent, knowledge, access to
information and opportunity to correct or prevent such statement or omission. The Company and the Holders agree that it would
not be just and equitable if contribution pursuant to this Section 4.4 were based solely upon the number of
entities from whom contribution was requested or by any other method of allocation which does not take account of the
equitable considerations referred to above in this Section 4.4. In no event shall any Holder's contribution obligation
under this Section 4.4 exceed the amount by which the net proceeds actually received by such Holder from the sale of
Registrable Securities included in such registration exceeds the amount of any other losses, expenses, settlements, damages,
claims and liabilities that such Holder has been required to pay by reason of such untrue or alleged untrue statement or
omission or alleged omission or violation. No Person guilty of fraudulent misrepresentation (within the meaning of the
Securities Act) shall be entitled to contribution from any Person who was not guilty of such fraudulent
misrepresentation.

 

    12

     

    

 

Article
V

Transfer and Termination of Registration Rights

 

Section 5.1           
Transfer of Registration Rights. The rights to cause the Company to register securities granted to a Holder under
this Agreement may be assigned to any Person in connection with any Transfer (as defined in the Securities Purchase Agreement)
or assignment of Registrable Securities to in a Transfer permitted by Section 4.2 of the Securities Purchase Agreement; provided,
however, that (a) such transfer may otherwise be effected in accordance with applicable securities laws, (b) prior
written notice of such assignment is given to the Company, and (c) such transferee agrees in writing to be bound by, and subject
to, this Agreement as a “Holder” pursuant to a written instrument in form and substance reasonably acceptable to the
Company.

 

Section 5.2           
Termination of Registration Rights. The rights of any particular Holder to cause the Company to register securities
under Articles I and II shall terminate with respect to such Holder upon the date upon which such Holder no longer
holds any Registrable Securities.

 

Article
VI

Miscellaneous.

 

Section 6.1           
Counterparts. This Agreement may be executed in one or more counterparts, all of which shall be considered one and
the same agreement, and will become effective when one or more counterparts have been signed by a party and delivered to the other
parties. Copies of executed counterparts transmitted by telecopy, telefax or other electronic transmission service shall be considered
original executed counterparts for purposes of this Section 6.1, provided that receipt of copies of such counterparts is
confirmed.

 

Section 6.2           
Governing Law.

 

(a)              
This Agreement shall be governed by, and construed in accordance with, the laws of the state of New York (except to the
extent that mandatory provisions of the laws of the state of Nevada are applicable), without giving effect to any choice of law
or conflict of law rules or provisions (whether of the state of New York or any other jurisdiction) that would cause the application
of the laws of any jurisdiction other than the state of New York.

 

(b)               Any
dispute relating hereto shall be heard in the U.S. District Court for the Southern District of New York (and any federal
appellate courts therefrom) (and to the extent such court declines jurisdiction, state court located in the Borough of
Manhattan) (each a “Chosen Court” and collectively, the “Chosen Courts”), and the
parties agree to the exclusive jurisdiction and venue of the Chosen Courts. Such Persons further agree that any proceeding
seeking to enforce any provision of, or based on any matter arising out of or in connection with, this Agreement or the
transactions contemplated hereby or by any matters related to the foregoing (the “Applicable Matters”)
shall be brought exclusively in a Chosen Court, and that any proceeding arising out of this Agreement or any other Applicable
Matter shall be deemed to have arisen from a transaction of business in the state of New York, and each of the foregoing
Persons hereby irrevocably consents to the jurisdiction of such Chosen Courts in any such proceeding and irrevocably and
unconditionally waives, to the fullest extent permitted by law, any objection that such Person may now or hereafter have to
the laying of the venue of any such suit, action or proceeding in any such Chosen Court or that any such proceeding brought
in any such Chosen Court has been brought in an inconvenient forum.

 

    13

     

    

 

(c)              
Such Persons further covenant not to bring a proceeding with respect to the Applicable Matters (or that could affect any
Applicable Matter) other than in such Chosen Court and not to challenge or enforce in another jurisdiction a judgment of such Chosen
Court.

 

(d)              
Process in any such proceeding may be served on any Person with respect to such Applicable Matters anywhere in the world,
whether within or without the jurisdiction of any such Chosen Court. Without limiting the foregoing, each such Person agrees that
service of process on such party as provided in Section 6.5 shall be deemed effective service of process on such Person.

 

(e)              
Waiver of Jury Trial. EACH PARTY HERETO, FOR ITSELF AND ITS AFFILIATES, HEREBY IRREVOCABLY AND UNCONDITIONALLY WAIVES
TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW ALL RIGHT TO TRIAL BY JURY IN ANY ACTION, SUIT OR OTHER PROCEEDING (WHETHER BASED
ON CONTRACT, TORT OR OTHERWISE) ARISING OUT OF OR RELATING TO THE ACTIONS OF THE PARTIES HERETO OR THEIR RESPECTIVE AFFILIATES
PURSUANT TO THIS AGREEMENT OR IN THE NEGOTIATION, ADMINISTRATION, PERFORMANCE OR ENFORCEMENT HEREOF.

 

Section 6.3           
Entire Agreement; No Third Party Beneficiary. This Agreement and the Securities Purchase Agreement contain the entire
agreement by and among the parties with respect to the subject matter hereof and all prior negotiations, writings and understandings
relating to the subject matter of this Agreement. Except as provided in Article IV, this Agreement is not intended to confer
upon any Person not a party hereto (or their successors and permitted assigns) any rights or remedies hereunder.

 

Section 6.4           
Expenses. Except as provided in Section 3.3, all fees, costs and expenses incurred in connection with this
Agreement and the transactions contemplated hereby, including accounting and legal fees shall be paid by the party incurring such
expenses. The fees specified in clause (b) of the definition of “Registration Expenses” incurred in connection with
any Shelf Registration or Underwritten Offering pursuant to this Agreement shall, in each case, not exceed $50,000.

 

Section 6.5            Notices.
All notices, requests, demands and other communications under this Agreement shall be in writing and shall be deemed to have
been duly given or made as follows: (a) if sent by registered or certified mail in the United States return receipt
requested, upon receipt; (b) if sent by nationally recognized overnight air courier, one (1) Business Day after mailing;
(c) if sent by e-mail transmission, with a copy sent on the same day in the manner provided in the foregoing clause (a)
or (b), when transmitted and receipt is confirmed; and (d) if otherwise actually personally delivered, when delivered, provided,
that such notices, requests, demands and other communications are delivered to the address set forth below, or to such other
address as any party shall provide by like notice to the other parties to this Agreement:

 

    14

     

    

 

If to the Company, to:

 

Cryoport, Inc.

112 Westwood Place, Suite 350

Brentwood, TN 37027

Attention:(i) Jerrell Shelton, President, Chief
Executive Officer, and Chairman of the Board, (ii) Robert Stefanovich, Chief Financial Officer, Treasurer and Corporate Secretary,
and (iii) Tony Ippolito, Vice President and General Counsel.

Email: JShelton@cryoport.com; RStefanovich@cryoport.com; and TIppolito@cryoport.com

 

with a copy (which shall not constitute notice) to:

 

Latham & Watkins LLP

650 Town Center Drive, 20th Floor

Costa Mesa, CA 92626

Attention: Daniel Rees

Email: Daniel.Rees@lw.com

 

If to the Investor, to:

 

Blackstone Freeze Parent L.P.

c/o The Blackstone Group Inc.

345 Park Avenue

New York, NY 10154

Attention: Ram Jagannath

E-mail: Ram.Jagannath@Blackstone.com

 

with a copy (which shall not constitute notice) to:

 

Simpson Thacher & Bartlett LLP

425 Lexington Ave

New York, New York 10017

Attention: Anthony F. Vernace

E-mail: avernace@stblaw.com

 

Section 6.6           
Successors and Assigns. This Agreement will be binding upon and inure to the benefit of the parties hereto and their respective
successors and permitted assigns. Except as provided in Section 5.1, no assignment of this Agreement or of any rights or
obligations hereunder may be made by any party hereto without the prior written consent of the other parties hereto. Any purported
assignment or delegation in violation of this Agreement shall be null and void ab initio.

 

Section 6.7           
Headings. The Section, Article and other headings contained in this Agreement are inserted for convenience of reference
only and will not affect the meaning or interpretation of this Agreement.

 

    15

     

    

 

Section 6.8           
Amendments and Waivers. This Agreement may not be modified or amended except by an instrument or instruments in writing
signed by the Company and the Holders of a majority of the Registrable Securities outstanding at the time of such amendment. Any
party hereto may, only by an instrument in writing, waive compliance by any other party or parties hereto with any term or provision
hereof on the part of such other party or parties hereto to be performed or complied with. No failure or delay of any party in
exercising any right or remedy hereunder shall operate as a waiver thereof, nor will any single or partial exercise of any right
or power, or any abandonment or discontinuance of steps to enforce such right or power, preclude any other or further exercise
thereof or the exercise of any other right or power. The waiver by any party hereto of a breach of any term or provision hereof
shall not be construed as a waiver of any subsequent breach. The rights and remedies of the parties hereunder are cumulative and
are not exclusive of any rights or remedies that they would otherwise have hereunder.

 

Section 6.9           
Interpretation; Absence of Presumption.

 

(a)              
For the purposes hereof: (i) words in the singular shall be held to include the plural and vice versa and words of one gender
shall be held to include the other gender as the context requires; (ii) the terms “hereof,” “herein,” and
 “herewith” and words of similar import shall, unless otherwise stated, be construed to refer to this Agreement as a
whole and not to any particular provision of this Agreement, and Section and paragraph references are to the Sections and paragraphs
in this Agreement unless otherwise specified; (iii) the word “including” and words of similar import when used in this
Agreement shall mean “including, without limitation,” unless the context otherwise requires or unless otherwise specified;
and (iv) the word “or” , “any” or “either” shall not be exclusive. References to a Person are
also to its permitted assigns and successors. When calculating the period of time between which, within which or following which
any act is to be done or step taken pursuant to this Agreement, the date that is the reference date in calculating such period
shall be excluded (and unless, otherwise required by Law, if the last day of such period is not a Business Day, the period in question
shall end on the next succeeding Business Day)

 

(b)              
With regard to each and every term and condition of this Agreement, the parties hereto understand and agree that the same
have or has been mutually negotiated, prepared and drafted, and if at any time the parties hereto desire or are required to interpret
or construe any such term or condition, no consideration will be given to the issue of which party hereto actually prepared, drafted
or requested any term or condition of this Agreement.

 

Section 6.10       
Severability. Any provision hereof that is held to be invalid, illegal or unenforceable in any respect by a court of competent
jurisdiction, shall be ineffective only to the extent of such invalidity, illegality or unenforceability, without affecting in
any way the remaining provisions hereof, provided, however, that the parties will attempt in good faith to reform
this Agreement in a manner consistent with the intent of any such ineffective provision for the purpose of carrying out such intent.

 

(The next page is the signature page)

 

    16

     

    

 

IN WITNESS WHEREOF, the parties have executed
this Registration Rights Agreement as of the date first above written. 

 

	 	CRYOPORT, INC.
	 	 
	 	 
	 	By: 	/s/ Jerrell Shelton
	 	 	Name: 	Jerrell Shelton
	 	 	Title:	President & CEO
	 	 
	 	 
	 	BLACKSTONE FREEZE PARENT L.P.
	 	 
	 	By: 	BTO Holdings Manager L.L.C., its general partner
	 	 
	 	By:	/s/ Christopher J. James
	 	 	Name:	Christopher J. James
	 	 	Title:	Authorized Person

 

[Signature Page to Registration Rights Agreement]

 

    S-1

     

    

 

EXHIBIT A

DEFINED TERMS

 

1.       The
following capitalized terms have the meanings indicated:

 

“Affiliate”
of any Person means any Person, directly or indirectly, controlling, controlled by or under common control with such Person.

 

“Automatic
Shelf Registration Statement” means an “automatic shelf registration statement” as defined under Rule 405.

 

“Commission”
means the Securities and Exchange Commission.

 

“Common Stock”
means the Company’s common stock, par value $0.001 per share.

 

“Exchange
Act” means the Securities Exchange Act of 1934, as amended, or any similar successor federal statute, and the rules and
regulations of the Commission thereunder, all as the same shall be in effect from time to time.

 

“Holder”
means (a) any Investor holding Registrable Securities and (b) any transferee to which the rights under this Agreement have been
transferred in accordance with Section 5.1.

 

“Person”
means an individual, corporation, partnership, limited liability company, joint venture, association, trust, unincorporated organization,
other legal entity, or any government or governmental agency or authority.

 

“register”,
 “registered” and “registration” refer to a registration effected by preparing and filing
a registration statement in compliance with the Securities Act, and the declaration or ordering of the effectiveness of such registration
statement.

 

“Registration
Expenses” means (a) all expenses incurred by the Company in complying with this Agreement, including, without limitation,
internal expenses, all registration, qualification, listing and filing fees, printing expenses, escrow fees, rating agency fees,
fees and disbursements of the Company’s independent registered public accounting firm, fees and disbursements of counsel
for the Company, blue sky fees and expenses and (b) the fees and expenses of one counsel to the Holders in connection with this
Agreement; provided, however, that Registration Expenses shall not include any Selling Expenses.

 

“Registrable
Securities” means (a) any shares of Common Stock issued or issuable upon conversion of the Series C Convertible
Preferred Stock, (b) the shares of Common Stock issued to the Investor pursuant to the Securities Purchase Agreement and (c)
any Common Stock actually issued in respect of the securities described in clauses (a) or (b) above or this clause (c) upon
any stock split, stock dividend, recapitalization, reclassification, merger, consolidation or similar event; provided, however,
that the securities described in clauses (a), (b) and (c) above shall only be treated as Registrable Securities until the
earliest of: (i) the date on which such security has been registered under the Securities Act and disposed of in accordance
with an effective Registration Statement relating thereto; (ii) the date on which such security has been sold pursuant to
Rule 144 and the security is no longer a Restricted Security; or (iii) the date on which such security is transferred in a
transaction pursuant to which the registration rights are not also assigned in accordance with Section 5.1.

 

    A-1

     

    

 

“Restricted
Securities” means any Common Stock required to bear the legend set forth in Section 4.3(a) of the Securities Purchase
Agreement.

 

“Rule 144”
means Rule 144 promulgated under the Securities Act and any successor provision.

 

“Rule 405”
means Rule 405 promulgated under the Securities Act and any successor provision.

 

“Securities
Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder or any similar
federal statute and the rules and regulations of the Commission thereunder, all as the same shall be in effect at the time.

 

“Selling Expenses”
means (a) all underwriting discounts, selling commissions and stock transfer taxes applicable to the securities registered by the
Holders and (b) the fees and expenses of any counsel to the Holders.

 

“Series C
Convertible Preferred Stock” means the Company’s Series C Convertible Preferred Stock, par value $0.001 per share.

 

“Shelf Registration”
means the Resale Shelf Registration or a Subsequent Shelf Registration, as applicable.

 

“Transfer”
has the meaning given to such term in the Securities Purchase Agreement.

 

“WKSI”
means a “well known seasoned issuer” as defined under Rule 405.

 

2.       The
following terms are defined in the Sections of the Agreement indicated:

 

INDEX OF TERMS

 

	Term	 	Section
	Agreement	 	Preamble
	Applicable Matters	 	Section 6.2(b)
	Chosen Court	 	Section 6.2(b)
	Company	 	Preamble
	Company Indemnified Parties	 	Section 4.1
	Effectiveness Period	 	Section 1.2
	Holder	 	Section 5.1
	Holder Indemnified Parties	 	Section 4.2
	Indemnified Party	 	Section 4.3
	Indemnifying Party	 	Section 4.3
	Investor	 	Preamble
	Market Stand-Off	 	Section 3.6
	Resale Shelf Registration	 	Section 1.1
	Securities Purchase Agreement	 	Preamble
	Subsequent Holder Notice	 	Section 1.5
	Subsequent Shelf Registration	 	Section 1.3
	Underwritten Offering	 	Section 1.6

 

    A-2

     

    

 

REGISTRATION RIGHTS AGREEMENT JOINDER

 

The undersigned is
executing and delivering this joinder (this “Joinder”) pursuant to the Registration Rights Agreement,
dated as of October 1, 2020 (as the same may hereafter be amended, the “Registration Rights Agreement”),
between Cryoport, Inc., a Nevada corporation (the “Company”), and Blackstone Freeze Parent L.P. Capitalized
terms used but not otherwise defined herein shall have the meanings provided in the Registration Rights Agreement.

 

By executing and delivering
this Joinder to the Company, and upon acceptance hereof by the Company upon the execution of a counterpart hereof, the undersigned
hereby agrees to become a party to, to be bound by, and to comply with the Registration Rights Agreement as a Holder in the same
manner as if the undersigned were an original signatory to the Registration Rights Agreement.

 

[Signature Pages Follow]

 

    

     

    

 

Accordingly, the undersigned
has executed and delivered this Joinder as of the 1st day of October, 2020.

 

 

	 	BLACKSTONE TACTICAL OPPORTUNITIES FUND – FD L.P.
	 	 
	 	By: 	Blackstone Tactical Opportunities Associates III
 – NQ L.P., its general partner
	 	 
	 	By: 	BTO DE GP – NQ L.L.C., its general partner
	 	 
	 	By:	 /s/ Christopher J. James
	 	Name: 	Christopher J. James
	 	Its:	Authorized Person

 

	Agreed and Accepted as of October 1, 2020	 
	 	 
	 	 
	CRYOPORT, INC.	 
	 	 
	By: 	/s/ Jerrell
    Shelton	 
	Name:	Jerrell Shelton	 
	Its: 	President & Chief Executive OfficerExhibit 10.2

 

AMENDMENT N°1 TO THE SECURITIES PURCHASE
AGREEMENT WITH RESPECT TO ADVANCED THERAPY LOGISTICS AND SOLUTIONS SAS

 

This amendment n°1 to the securities
purchase agreement with respect to Advanced Therapy Logistics And Solutions SAS dated as of August 21st, 2020 (the
 “Amendment Agreement”) is entered into by and between:

 

	(1)	Cryoport, Inc., a corporation organized
under the laws of the State of Nevada having its principal place of business at 112 Westwood Place – Suite 350, Brentwood,
Tennessee 37027, duly represented and authorized for the purposes hereof (hereinafter referred to as the "Purchaser"
or "Cryoport"); and

 

	(2)	Cryoport Netherlands B.V., a Dutch company
having its registered office located at Parellaan 18, 2132WS Hoofddorp, Netherlands and registered within the Netherlands Chamber
of Commerce Business Register under number 858683751 (RSIN) and 000039547469 (establishment number), duly represented and authorized
for the purposes hereof ("Cryoport Netherlands");

 

On the one hand,

 

And each of:

 

	(3)	Hivest I FPCI, a fonds professionnel de
capital investissement governed by articles L. 214-159 et seq. of the French Code monétaire et financier,
represented by its management company (société de gestion), Hivest Capital Partners, a company (société
par actions simplifiée) organized under the laws of France, having its registered office at 24, rue de Prony, 75017,
Paris, France, registered with the trade and companies registry of Paris under number 823 869 979 (hereinafter referred to
as "Hivest Capital Partners"), represented by Mr. Cédric Lépée, duly authorized for
the purposes hereof;

 

	(4)	ATLAS Co-Invest FPS, a fonds professionnel
spécialisé represented by its management company (société de gestion), Hivest Capital Partners,
a company (société par actions simplifiée) organized under the laws of France, having its registered
office at 24, rue de Prony, 75017, Paris, France, registered with the trade and companies registry of Paris under number 823 869
979, represented by Mr. Cédric Lépée, duly authorized for the purposes hereof;

 

	(5)	Tikehau Direct Lending IV, a sub-fund of Tikehau
Investment II S.C.S, SICAV-SIF, an investment company with variable capital (société d’investissement à
capital variable) organised as multi sub-fund specialised investment fund (fonds d’investissement spécialisé)
established as a limited partnership (société en commandite simple), incorporated under the laws of the Grand-Duchy
of Luxembourg, registered with the Luxembourg Register of Commerce and Companies under number B-215.556 and having its registered
address at 60, avenue J.F. Kennedy, L-1855 Luxembourg Grand Duchy of Luxembourg, represented by Tikehau General Partner II S.à
r.l., a limited liability company (société à responsabilité limitée) incorporated under
the laws of the  Grand-Duchy of Luxembourg, registered with the Luxembourg Register of Commerce and Companies under number
B-215.499 and having its registered office at 60, avenue J.F. Kennedy, L-1855 Luxembourg, Grand Duchy of Luxembourg, acting in
its capacity of general partner of Tikehau Investment II S.C.S, SICAV-SIF, itself represented by Tikehau Investment Management
acting in its capacity of alternative investment fund manager and duly represented for the purposes hereof;

 

	(6)	Tikehau Mercati Privati Europei, an Italian
non-reserved closed-ended alternative investment fund (fondo di investimento alternativo di tipo chiuso non riservato) represented
by its management company Tikehau Investment Management, a French société par actions simplifiée, having
its registered office at 32, rue de Monceau 75008, Paris, France, registered with the Paris Register of Commerce and Companies
under number 491 909 446 and duly represented for the purposes hereof;

 

    1

     

    

 

	(7)	MTDL, a special limited partnership (société
en commandite spéciale) incorporated under the laws of the Grand-Duchy of Luxembourg, registered with the Luxembourg
Register of Commerce and Companies under number B-231.397 and having its registered office at 60, avenue J.F. Kennedy, L-1855 Luxembourg,
Grand Duchy of Luxembourg, represented by Tikehau General Partner II S.à r.l., a limited liability company (société
 à responsabilité limitée) incorporated under the laws of the  Grand-Duchy of Luxembourg, registered
with the Luxembourg Register of Commerce and Companies under number B-215.499 and having its registered office at 60, avenue J.F.
Kennedy, L-1855 Luxembourg, Grand Duchy of Luxembourg, acting in its capacity of general partner of MTDL, itself represented by
Tikehau Investment Management acting in its capacity of alternative investment fund manager and duly represented for the purposes
hereof;

 

	(8)	FPCI Swen CO-Invest 2, a fonds professionnel
de capital investissement managed by Swen Capital Partners, a French société anonyme having its registered office
located at 20-22 rue Vernier, 75017, Paris, France, registered with the trade and companies registry of Paris under number 803
812 593 and duly represented for the purposes hereof;

 

	(9)	Mr. Cédric Picaud, born on 9 December 1974
in Saint-Martin-d'Hères (38) residing 356, Chemin du Cret, 01170 GEX, France;

 

	(10)	Mr. Guillaume Chevillon, born on 21 April 1981
in Paris 14e (75) residing 29, rue de la Fontaine au Roi, 75011 Paris, France;

 

	(11)	Mrs. Karine Gradziel, born on 12 December 1966
in Mans (72) residing 23, Avenue Balzac, 94210 Saint-Maur-des-Fossés, France;

 

	(12)	Mr. Tangi Tremorin, born on 5 avril 1975
in Léhon (22) residing 344, Route de la Carnalaz, 73420 Drumettaz Clarafond, France;

 

	(13)	Mrs. Berangere Delahaye, born on 23 February1976
in Versailles (78) residing 11, rue Eugène Carrière, 75018 Paris, France;

 

	(14)	Mr. Sebastien Oudard, born on 29 November 1975
in Romilly-sur-Seine (10) residing 15, Lotissement du Chemin Neuf, 42410 Chavanay, France;

 

	(15)	Mr. Nicolas Pedrono, born on 7 May 1975
 à Caen (14) residing R Palmeiras 53 4C, Parede, 2775-347 Parede, Portugal;

 

	(16)	Mr. Mark Pettler, born on 26 December 1963
in Hartlepool (Angleterre) residing 3, Weyview Close, Guildford, Surrey GU1 1HN, United Kingdom;

 

	(17)	Mr. Girish Pattathil Radhakrishnan, born
on 3 December 1959 in Mannur, Kerala (Inde) residing 307 Silver Creast, C Wing RAHEJA VIHAR, Chandivali Studio, Chandivali,
Andheri East, Mumbai, Maharashtra 400072, India; and

 

	(18)	Mr. Wasim Dawood Dingankar, born on 10
August 1974 in Mumbai, Maharashtra (Inde) residing Carlton Patalipada Carlton CHSL, Flat 301 9th Floor, Hiranandani Estate,
Ghod Bunder, Road, Thane, 400607, India;
	 	 
	 	the Parties listed under (3) to
(18) above, acting severally but not jointly (conjointement mais non solidairement), are hereinafter referred to collectively
as the "Sellers" and individually as a "Seller".

 

 

On the other hand.

    2

     

    

 

The Purchaser and the Sellers are hereinafter
referred to collectively as the "Parties" and individually as a "Party".

 

In the presence of:

 

		(19)	Advanced Therapy Logistics And Solutions,
a société par actions simplifiée organized under the laws of France, having its registered office at
24, rue de Prony, 75017, Paris, France, registered with the trade and companies registry of Paris under number 841 182 272,
represented by Mr. Cédric Picaud duly authorized for the purposes hereof (hereinafter referred to as "ATLAS"
or the "Company").

 

Capitalized terms not otherwise defined
in this Amendment Agreement shall have the meaning ascribed to them in the Securities Purchase Agreement (as this term is defined
below).

 

Whereas:

 

		(A)	On 21 August 2020, the Parties entered into a securities purchase agreement in respect of
the acquisition by the Purchaser from the Sellers of 100% of the Transferred Securities (the “Securities Purchase
Agreement”).

 

		(B)	In accordance with the provisions of clause 5.1 of the Securities Purchase Agreement, the Parties
were initially contemplating to hold the Closing of the Transaction on 30 September 2020. However, to address accounting constraints
pertaining to the Cryoport group (to which the Purchaser belongs), the Parties have agreed to amend the Securities Purchase Agreement
with a view to (i) agreeing on, and formalizing, a Closing Date by 1 October 2020, (ii) crystallizing
the financial aggregates provided for under the Securities Purchase Agreement on 30 September 2020, in particular for
the purpose of determining the Post-Closing Adjustment which shall remain based on Closing Balance Sheet as of 30 September 2020
and (iii) formalizing, subject to the terms and conditions hereof, the subrogation of Cryoport Netherlands into the
contractual position of Cryoport (i.e., Cryoport assigning to Cryoport Netherlands its rights and obligations under the Securities
Purchase Agreement but remaining fully jointly and severally liable with Cryoport Netherlands for any liability and obligation
of Cryport Netherlands under the Securities Purchase Agreement including, inter alia, in respect of the payment to
the Sellers of the Closing Payment, the amount of the Post-Closing Adjustment (if any) and, more generally, any other sums due
by the Sellers under the Securities Purchase Agreement).

 

		(C)	In order to reflect the foregoing, the Parties desire to amend certain provisions of the Securities
Purchase Agreement and therefore enter into this Amendment Agreement.

 

It is hereby agreed as follows:

 

		1.	Amendment of certain definitions of the Securities Purchase Agreement

 

		1.1.	The Parties agree that the definition of "Actual Closing Net Debt" of the
Securities Purchase Agreement is hereby amended and shall now read as follows:

 

“"Actual Closing
Net Debt" means the actual Net Debt of the Group Companies as at 30 September 2020 as resulting from the Closing
Balance Sheet as finally determined and agreed between the Sellers’ Representative and the Purchaser or as otherwise determined
in accordance with Section 3.4(d);”.

  

    3

     

    

 

		1.2.	The Parties agree that the definition of "Actual Closing Working Capital"
of the Securities Purchase Agreement is hereby amended and shall now read as follows:

 

“"Actual Closing
Working Capital" means the actual Working Capital of the Group Companies as at 30 September 2020 as resulting
from the Closing Balance Sheet as finally determined and agreed between the Sellers’ Representative and the Purchaser or
as otherwise determined in accordance with Section 3.4(d);”.

 

		1.3.	The Parties agree that paragraphs (iii) and (iv) of the definition of "Cash"
of the Securities Purchase Agreement is hereby amended and shall now read as follows:

 

“(iii) “CFE
Recovery”: the difference between (1) the total amount of CFE (cotisations foncières des entreprises) to be recovered
by the French subsidiaries amounting to two hundred and ten thousand (EUR 210,000.00) (such amount is a fixed amount, mutually
agreed by the Parties as such) and (2) the amount of CFE actually recovered at 30 September 2020 or, and without
double counting, accounted in the Working Capital;

 

(iv) A fixed amount of
one hundred sixteen thousand euros (EUR 116,000.00) placed in an escrow account for the benefit of Spirit as part of the new Tremblay
lease, it being understood that this amount shall be decreased by the amount already recovered at 30 September 2020 or,
and without double counting, the amount accounted in the Working Capital”.

 

The other provisions of the definition
of "Cash" of the Securities Purchase Agreement shall remain unchanged.

 

		1.4.	The Parties agree that the definition of "Existing Indebtedness" of the
Securities Purchase Agreement is hereby amended and shall now read as follows:

 

"Existing Indebtedness"
means all outstanding and unpaid amounts owing as at 30 September 2020 (in principal, interest, penalties and any other
sums) by the Group Companies, pursuant to, or in connection with, the Existing Facilities (including, without limitation, all break
fees due in connection with the voluntary prepayment of any sums due by the Company pursuant to, or in connection with the Existing
Facilities), as determined in accordance with the terms of the Existing Facilities.”.

 

		1.5.	The Parties agree that paragraph (iii), (ix), (x), (xii) and (xvii) of the definition
of "Indebtedness" of the Securities Purchase Agreement is hereby amended and shall now read as follows:

 

“(iii) deferred
purchase price of assets, property, securities, goods or services (in each case, other than in the ordinary course of business)
including the non-contingent amount of any current or future obligations under any “earn-outs” or similar obligations
(including, if non-contingent, (i) any amounts due to former owners of any Group Company or “Company notes” payable,
and (ii) any amounts payable attributable to the period prior to 30 September 2020,

 

(...)

 

(ix) “Remaining
Carve-Out Costs”: the difference between (1) one million four hundred thirty-two thousand euros (EUR 1,432,000.00)
which corresponds to the budgeted carve-out costs (IT, rebranding, relocation from Bobigny to Tremblay, SAGE, accounting and finance)
excl. VAT or its foreign equivalent as mutually agreed upon by the Parties and (2) carve-out costs, excl. VAT, having already
being accounted as of 30 September 2020 (to the extend paid on or prior to 30 September 2020 or reflected in Working
Capital), it being understood that if the Closing Date were 30-June-2020, the Remaining Carve-Out Costs would be one million two
hundred thousand euros (EUR 1,200,000.00) as mutually agreed upon by the Parties,

 

(x) “Pension
Costs”: an amount of one hundred seventy-six thousand euros (€176,000) for the purpose of the accrued and unpaid
obligations in respect of severance due (and that should reasonably be payable during a period not exceeding 10 years after 30
September 2020) as mutually agreed upon by the Parties,

 

    4

     

    

 

(...)

 

(xii) “Unpaid
Settlement Not Covered”: the difference, if it is a positive amount, between (1) one hundred thousand euros (EUR
100,000.00) and (2) costs already accounted before 30 September 2020 (to the extend paid on or prior to 30 September 2020
or reflected in Working Capital) regarding the on-going litigation in Israel between PDP Courier Services Ltd and PDP Israël
Ltd., an Israeli company registered under number 514694736 with the trade and companies registry (including costs and expenses
incurred in connection to the litigation), it being understood that if the Closing Date were 31-July-2020, the Unpaid Settlement
Not Covered would be fifty-nine thousand and one hundred euros (EUR 59,100.00),

 

(...)

 

(xvii) any amounts owed
(and not paid at 30 September 2020) to Sellers or their Affiliates other than salary or compensation due to individual Sellers
that are also an officer of employee of a Group Company solely for their salary or compensation for such services and excluding
any compensation arising out of the AL/Hivest Transaction or the transactions contemplated by this Agreement,”.

 

The other provisions of the definition
of "Indebtedness" of the Securities Purchase Agreement shall remain unchanged.

 

		1.6.	The Parties agree that the definition of "Leakage" of the Securities Purchase
Agreement is hereby amended and shall now read as follows:

 

“"Leakage"
means, other than Permitted Leakage, the sum of the amounts resulting from any of the following events to the extent it would occur
after the Effective Date and prior to, or as of, 30 September 2020 without being taken into account in the Purchase Price,
Actual Closing Net Debt (notably through a decrease of the Cash or an Increase of the Indebtedness) or Actual Closing Working Capital
(through, for example, an increase in payables and/or provisions):

 

(...)

 

(ii) any Transaction
Costs incurred prior to 30 September 2020, not included in the Actual Closing Net Debt or the Actual Closing Working Capital,
and to be paid after 30 September 2020;”.

 

The other provisions of the definition
of "Leakage" of the Securities Purchase Agreement shall remain unchanged.

 

		1.7.	The Parties agree that the definition of "Transaction Costs" of the Securities Purchase
Agreement is hereby amended and shall now read as follows:

 

““Transaction
Costs” means any fees, expenses or other costs agreed to be paid or paid by any Group Company after 30 September 2020
or prior to or on 30 September 2020 but not included in the Actual Net Debt or in the Actual Working Capital, in respect of
(i) the Transaction or the transactions contemplated by this Agreement by any Group Company (to the extent such fees, expenses
or other costs are paid or payable for the sole account of the Sellers) and (ii) the AL/Hivest Transaction or the transactions
contemplated by the AL SPA by any Group Company (but excluding any Remaining Carve-out Costs). The amounts of the Transaction Costs
as at 21 August 2020 are in Section 13.6.1 of the Data Room (minor changes may be expected as of 30 September 2020);”.

 

    5

     

    

 

		1.8.	The Parties agree that the last paragraph of clause 3.1(a) of the Securities Purchase
Agreement is hereby amended and shall now read as follows:

 

“in each case as finally
determined in accordance with Section 3.4(d) (the "Purchase Price").”.

 

The other provisions of clause
3.1(a) of the Securities Purchase Agreement shall remain unchanged.

 

		1.9.	The Parties agree that the first paragraph of clause 3.4(d) of the Securities Purchase
Agreement is hereby amended and shall now read as follows:

 

“Closing Balance
Sheet; Computation of Post-Closing Adjustment. Within sixty (60) Business Days after the Closing Date, the Purchaser shall
procure that the Company prepare a consolidated balance sheet (bilan consolidé) as at the start of business on 30 September 2020
(the "Closing Balance Sheet"), in the same format as the balance sheet included in Schedule 3.4(d), in accordance with
the Accounting Principles and reviewed by Ernst & Young in compliance with applicable relevant Accounting Principles.
As soon as reasonably practicable, and in any event by no later than five (5) Business Days after the Closing Balance Sheet
has been made available to the Purchaser, the Purchaser shall deliver to the Sellers’ Representative a copy of the Closing
Balance Sheet and a statement (the "Purchaser’s Statement"), signed by an authorized representative of the Purchaser,
setting forth in reasonable detail a computation as of 30 September 2020 of the following amounts (the “Adjustment Amounts”)
(i) the Indebtedness in the Closing Balance Sheet, (ii) the Cash in the Closing Balance Sheet, (iii) the Actual
Closing Net Debt, (iv) the Actual Closing Working Capital, and (v) the Post-Closing Adjustment. As from the date of the
delivery of the Purchaser’s Statement, the Purchaser shall, subject to reasonable notice, make available to the Sellers’
Representative the books, records and any other document and information relating to the Group Companies reasonably required by
the Sellers’ Representative in connection with its review of the Closing Balance Sheet and the Purchaser’s Statement.”.

 

The other provisions of clause
3.4(d) of the Securities Purchase Agreement shall remain unchanged.

 

		1.10.	The Parties agree that clause 5.1 (Date and Place of Closing) of the Securities Purchase
Agreement is hereby amended and shall now read as follows:

 

“5.1.       Date
and Place of Closing

 

The Closing takes place electronically
through the DocuSign platform on October 1st, 2020 or at any other later date which is the last day of a month
as notified by the Sellers’ Representative to the Purchaser with a 10-day prior notice at least but not later than the Long
Stop Date (the "Closing Date").”.

 

		1.11.	The Parties agree that the paragraph (iv) of clause 9(b) of the Securities Purchase
Agreement is hereby amended and shall now read as follows:

 

“(iv) there has
been no Leakage in the period from (and including) the Effective Date to (and including) 30 September 2020;”.

 

		1.12.	With respect to any actions to be taken by the Group Companies on 1 October 2020, each
Group Company shall maintain and carry on its business in the ordinary course of business as a going concern and there shall be
no Leakage.

 

    6

     

    

 

		1.13.	The Parties agree that Schedule (F) (Calculation of Target Closing Working Capital –
Specific policies) of the Securities Purchase Agreement is hereby amended and is fully replaced and restated by Schedule
(F) (Calculation of Target Closing Working Capital – Specific policies) attached as Appendix 1
to this Amendment Agreement.

 

		2.	Subrogation of Cryoport Netherlands in the rights and obligations of Cryoport under the Securities
Purchase Agreement

 

		2.1.	In accordance with clause 14.5(b) of the Securities Purchase Agreement, Cryoport hereby assigns
all of its rights and obligations under the Securities Purchase Agreement to Cryoport Netherlands, its wholly-owned Affiliate.

 

		2.2.	Cryoport Netherlands hereby accepts the foregoing assignment and hereby declares that (i) it
has read the Securities Purchase Agreement and (ii) it assumes and agrees to perform and to be liable for each and every obligation
of Cryoport, to the same extent as Cryoport, under the terms and conditions of the Securities Purchase Agreement including, inter
alia, in respect of the payment to the Sellers of the Closing Payments, the amount of the Post-Closing Adjustment (if any)
and, more generally, any other sums due by the Purchaser to the Sellers under the Securities Purchase Agreement.

 

		2.3.	Cryoport shall remain jointly and severally liable with Cryoport Netherlands for the performance
of the obligations (including payment obligations) under the Securities Purchase Agreement.

 

		2.4.	The assignment, together with the joint and several commitment of Cryoport under this clause 2
and the Securities Purchase Agreement, shall become effective as from the date hereof.

 

		2.5.	As a consequence of the foregoing, article 14.3 is hereby amended with respect to the Purchaser
as follows:

 

 

“If to the Purchaser,
to Cryoport Netherlands B.V.:

 

	 	Cryoport Netherlands
    B.V.
	 	Parellaan 18, 2132WS
    Hoofddorp, Netherlands
	 	Attn: Robert Stefanovich
    (director); Yvonne
	 	Theuns (director)
	 	Email: RStefanovich@cryoport.com
    ;
	 	ytheuns@cryoport.com
	 	 
	 	with a copy to:
	 	 
	 	Cryoport, Inc.
	 	112 Westwood Place –
    Suite 350
	 	Brentwood, Tennessee 37027
	 	Attn: Robert Stefanovich (CFO)
    ; Tony Ippolito
	 	(GC) 
	 	Email: RStefanovich@cryoport.com
    ;
	 	tippolito@cryoport.com
	 	 
	 	McDermott Will &
    Emery AARPI
	 	23, rue de l’Université
	 	75007 - Paris
	 	Attn: Me Bertrand Delafaye
	 	Email: bdelafaye@mwe.com »

 

    7

     

    

 

		3.	Payment by the Purchaser of the Closing Purchase Price and the Existing Indebtedness

 

On the Closing Date, the Purchaser
shall (i) pay the Closing Purchase Price and (ii) repay the Existing Indebtedness as per the instructions of the Sellers’
Representative as set out in Appendix 2 of this Amendment Agreement. The Purchaser shall be fully discharged
by any payment made at the Closing Date in accordance with, and subject to, this Appendix 2.

 

The Purchaser declares that the
funds used to satisfy its payment obligations under the Securities Purchase Agreement do not come from illegal activities or from
activities which contradict, or are likely to contradict, the provisions of any and all anti-corruption Laws or Laws against money
laundering, financing of terrorism or tax evasion and fraud applicable to it.

 

		4.	Reiteration of the Representations and Warranties

 

The representations and warranties
set forth in Article 8 of the Securities Purchase Agreement (Representations of the Sellers) and in Article 9
of the Securities Purchase Agreement (Representations and Warranties under the AL SPA) are repeated on the Closing Date.

 

		5.	Waiver of Article 5.2(a)(i) of the Securities Purchase Agreement

 

According to Article 5.2(a)(i) of
the Securities Purchase Agreement, the Sellers’ Representative shall deliver to the Purchaser the Accounts Closing Delivery
on the Closing Date.

 

Prior to the date hereof, the
Sellers’ Representative and the Purchaser have recognized and accepted that, given timing constraints, the Accounts Closing
Delivery, the final version of which is being finalized pending review and comments from the Purchaser, will not be delivered on
the Closing Date.

 

In order not the delay the completion
of the Transaction on October 1, 2020, the Purchaser acknowledges and agrees to waive the condition set forth in Article 5.2(a)(i) provided
that the Sellers’ Representative shall make its commercially reasonable efforts to assist, within the limit of its powers,
the Purchaser in the finalization of such Accounts Closing Delivery no later than October 31, 2020 it being specified and
agreed by the Parties that such reasonable assistance from the Sellers’ Representative shall not result in incurring the
liability of the Sellers’ Representative, in any manner whatsoever.

 

For the sake of clarity, and
notwithstanding the foregoing, the Parties hereby reiterate and agree that:

 

		-	the definition of “Cash” under the Securities Purchase Agreement shall include
any fees, including VAT, actually paid (or accounted and to the extent reflected in the Working Capital) to Crowe HAF or Daniel
Plessis to prepare the Accounts Closing Delivery; and

 

		-	the definition of “Unpaid Transaction Fees” under the Securities Purchase Agreement
shall exclude the fees owed to Crowe HAF or Daniel Plessis for preparing the Accounts Closing Delivery.

 

		6.	Miscellaneous

 

		6.1.	Any reference to the Securities Purchase Agreement shall be a reference to the Securities Purchase
Agreement as modified by this Amendment Agreement and the provisions of the Securities Purchase Agreement shall be interpreted
and construed in the light of this Amendment Agreement.

 

    8

     

    

 

		6.2.	This Amendment Agreement shall come into force as from the date hereof.

 

		6.3.	This Amendment Agreement shall not constitute an amendment or waiver of any other provisions (including
its schedules) of the Securities Purchase Agreement not expressly referred to herein. Except as expressly amended and/or superseded
hereby, the provisions of the Securities Purchase Agreement are, and shall remain, in full force and effect.

 

		6.4.	The provisions of clauses 13 (Confidentiality) and 14 (Miscellaneous) of the Securities Purchase
Agreement are incorporated by reference to this Amendment Agreement and shall apply mutatis mutandis.

 

		7.	Electronic signature

 

		7.1.	In accordance with articles 1366 and 1367 of the French civil code, this Amendment Agreement shall
be signed electronically by each of the authorized representatives of the Parties hereto. Each Party acknowledges that it has received
all the information required for the electronic signature of this Amendment Agreement and that it has signed this Amendment electronically
in full knowledge of the technology used and its terms and conditions, and consequently waives any claim and/or legal action challenging
the reliability of this electronic signature system and/or its intention to enter into this Amendment Agreement.

 

		7.2.	In accordance with the provisions of article 1375 of the French Code civil, the obligation
to deliver an original copy to each of the Parties hereto is not necessary as proof of the commitments and obligations of each
Party to this Amendment Agreement. The delivery of an electronic copy of this Amendment Agreement directly by DocuSign to each
Party shall constitute sufficient and irrefutable proof of the commitments and obligations of each Party to this Amendment Agreement.

 

Each Party acknowledge and agree, by exception
to the provisions of article 1161 of the French Code Civil, that a Party to this Amendment Agreement may represent, and act in
the name and on behalf of, another Party and, as such, to irrevocably waive its rights to require the invalidity and nullity of
the Amendment Agreement or any other agreement or document entered into in accordance with the terms and conditions of the Amendment
Agreement on the basis of article 1161 of the French Code Civil.

 

The effective date of signature of this
Amendment Agreement shall be the date of signature certified by the DocuSign platform.

 

 

	/s/ Robert Stefanovich	 	/s/ Robert Stefanovich
	 	 	 
	Cryoport, Inc.  	 	Cryoport Netherlands B.V.    
	By: Mr. Robert Stefanovich	 	By: Mr. Robert Stefanovich
	 	 	 
	 	 	 
	/s/ Cédric Picaud  	 	/s/ Cédric Picaud  
	 	 	 
	 	 	 
	Hivest I FPCI	 	Mr. Cédric Picaud
	Represented by Hivest Capital Partners SAS itself represented by Mr. Cédric Lépée   	 	 

 

    9

     

    

 

	Mr. Guillaume Chevillon	   	Mr. Tangi Tremorin
	 	 	By: Mr. Cédric Picaud
	 	 	 
	/s/ Cédric Picaud	 	/s/ Cédric Picaud
	 	 	 
		 	 
	Mrs. Berangere Delahaye            	 	Mr. Sebastien Oudard        
	By: Mr. Cédric Picaud	 	By: Mr. Cédric Picaud
	 	 	 
	 	 	 
	/s/ Cédric Picaud	 	/s/ Cédric Picaud
	 	 	 
	 	 	 
	Mr. Wasim Dingankar      	 	Mr. Mark Pettler      
	By: Mr. Cédric Picaud	 	By: Mr. Cédric Picaud
	 	 	 
	 	 	 
	/s/ Cédric Picaud	 	/s/ Cédric Picaud
	 	 	 
	 	 	 
	Mr. Nicolas Pedrono              	 	Mr. Girish Pattathil Radhakrishnan            
	By: Mr. Cédric Picaud	 	By: Mr. Cédric Picaud
	 	 	 
	 	 	 
	/s/ Cédric Picaud	 	/s/ Diego Felipe Aponte
	 	 	 
	 	 	 
	Mrs. Karine Gradziel	 	FPCI Swen Co-Invest 2      
	By: Mr. Cédric Picaud	 	By: Swen Capital Partners SA itself represented by Mr. Diego Felipe Aponte
	 	 	 
	 	 	 
	/s/ Cédric Lépée	 	/s/ Vincent Leprevots
	 	 	 
	 	 	 
	ATLAS Co-Invest FPS	 	Tikehau Direct Lending IV        
	By Hivest Capital Partners SAS represented by Mr. Cédric Lépée	 	By: Tikehau Associé II (SARL), itself represented by Tikehau Investment Management, itself represented by Mr. Vincent Leprevots

 

    10

     

    

 

	/s/ Vincent Leprevots	 	/s/ Vincent Leprevots
	 	 	 
	 	 	 
	 	 	 
	 	 	 
	Tikehau Mercati Privati Europei          	 	MTDL
	By: Tikehau Investment Management, itself represented by Mr. Vincent Leprevots	 	By: Tikehau General Partner II (SARL) represented by Tikehau Investment Management itself represented by Mr. Vincent Leprevots

 

	/S/ CÉDRIC PICAUD	 	 
	 	 	 
	 	 	 
	Advanced Therapy Logistics and Solutions SAS	 	 
	By: Mr. Cédric Picaud	 	 

 

    11

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