Document:

Exhibit 4.22

 

FIRST AMENDMENT TO 1.5% SENIOR CONVERTIBLE NOTE (RS-10)

 

This First Amendment to 1.5% Senior Convertible Note (RS-I 0) (this
"Amendment") is made and entered into as of February 27, 2017, by and between Amyris, Inc., a Delaware corporation
(the "Company") and Total Energies Nouvelles Activites USA (f.k.a. Total Gas & Power USA, SAS) (the "Investor").

 

RECITALS

 

WHEREAS, on March 21, 2016 the Company issued to the Investor
a 1.5% Senior Convertible Note (RS-10) in the principal amount of $3,700,000 (the "Note"), which Note is attached
hereto as Exhibit A.

 

WHEREAS, the Company and the Investor desire to amend the
Note as set forth herein.

 

WHEREAS, pursuant to Section 7 of the Note, the Note may be
amended with the written consent of the Company and the Investor.

 

NOW, THEREFORE, for good and valuable consideration, the receipt
and sufficiency of which is hereby acknowledged, the parties hereby agree as follows:

 

1.         Amendment
of Section 2(b) of the Note. Section 2(b) of the Note is hereby deleted in its entirety and replaced with the following:

 

(b)       Scheduled Payment of
Principal. Unless paid, converted or cancelled and extinguished earlier in accordance with the terms hereof, the Company shall
deliver to the Investor cash in the amount of the Face Amount, together with all accrued and unpaid interest on this Note, on May
15, 2017 (the "Final Maturity Date") and this Note shall be retired and canceled.

 

2.       Amendment
of Section 14 of the Note. Investor hereby designates the following address for purposes of receiving notice under the
Note.:

 

c/o Total Raffinage Chimie

2, place Jean Millier - La Defense 6

92078 Paris La Defense Cedex

France

Attn:

Fax. No.:

Email:

 

With a copy to (which shall not constitute notice):

Legal Department

Total Energies Nouvelles Activites USA

24 Cours Michelet

92800 Courbevoie

France

Attn: Department Head

 

    

     

    

 

3.        Full Force and
Effect. Except as expressly modified by this Amendment, the terms of the Note shall remain in full force and effect.

 

4.        Integration.
This Amendment and the Note constitute the entire agreement and understanding of the parties with respect to the subject matter
hereof, and supersede all prior understandings and agreements, whether oral or written, between or among the parties hereto with
respect to the specific subject matter hereof.

 

5.        Counterparts;
Facsimile. This Amendment may be executed in one (1) or more counterparts, each of which shall be deemed an original, but
all of which together shall constitute one and the same instrument. This Amendment may be executed and delivered by facsimile,
or by email in portable document format (.pdf), and delivery of any signature page by such method will be deemed to have the same
effect as if the original signature had been delivered to the other party.

 

[Remainder of Page intentionally
left blank)

 

 

 

    

     

    

 

IN WITNESS WHEREOF, the parties hereto have executed this
Amendment as of the date first above written.

 

	AMYRIS, INC.
	 	 	 
	 	 	 	 
	
        By:
	
        /s/ John Melo
	 	 	 	 
	
        Name:
	
        John Melo
	 	 	 	 
	
        Title:
	
        President & Chief Executive Officer
	 	 	 	 

 

 

 

[Signature Page to First Amendment to R&D Note]

 

    

     

    

 

IN WITNESS WHEREOF, the parties hereto have executed this
Amendment as of the date first above written.

 

	TOTAL ENERGIES NOUVELLES ACTIVITES USA

	 
	(F.K.A. TOTAL GAS & POWER USA, SAS)	 
	 	 	 	 
	
        By:
	
        /s/ Christophe Vuillez
	 	 	 	 
	
        Name:
	 Christophe Vuillez	 	 	 	 
	
        Title:
	
        Attorney in fact
	 	 	 	 

 

 

 

[Signature Page to First Amendment to R&D Note]

 

    

     

    

 

Exhibit A

 

See attached.Exhibit 4.37

 

January 10, 2017

 

Amyris, Inc.

5885 Hollis Street, Suite 100

Emeryville, CA 94608

Attention: John Melo, President and Chief Executive Officer

 

RE: Amendment to Loan and Security Agreement

 

Dear Mr. Melo:

 

Reference is made to that certain Loan and Security Agreement dated
as of March 29, 2014, as amended on June 12, 2014, March 31, 2015, November 30, 2015 and October 6, 2016 (as amended, the “LSA”),
by and between Amyris, Inc., a Delaware corporation (the “Parent”), and each of its Subsidiaries that
has delivered a Joinder Agreement (collectively, “Borrower”), the other financial institutions or entities
from time to time parties to the LSA (collectively, referred to as “Lender”) and Stegodon Corporation,
a Delaware corporation, as assignee of Hercules Capital, Inc., a Maryland corporation, in its capacity as administrative agent
for itself and Lender (in such capacity, the “Agent”). Capitalized terms used but not otherwise defined
herein have the meaning set forth in the LSA.

 

In connection with certain waivers of the debt and transfer covenants
under the LSA granted by Lender, Borrower, the Agent and Lender have agreed to amend Section 2.2(d) (“Term Loan – Payment”)
of the LSA, as well as make certain updates to the LSA, all as set forth herein.

 

For good and valuable consideration, the receipt and sufficiency
of which are hereby acknowledged, based upon the mutual covenants contained herein, Borrower, the Agent and Lender, in accordance
with Section 11.3(b) of the LSA, hereby amend the LSA (this “Amendment”) as follows:

 

I.        The definition
of “Fidelity Unsecured Convertible Debt” is hereby deleted in its entirety and the following is substituted therefor:

 

“Fidelity Unsecured Convertible
Debt” means the Indebtedness evidenced by those 9.50% Convertible Senior Notes issued on or about January 11, 2017 with a
maturity date of April 15, 2019 in the original principal amount of $19,136,000.

 

II.        New definitions
of “Earned Incentive Payments” and “Incentive Payments” are hereby inserted into Section 1 of the LSA in
appropriate alphabetical order:

 

“Earned Incentive Payments”
has the meaning ascribed to such term in the Ginkgo Collaboration Agreement.

 

“Incentive Payments” has
the meaning ascribed to such term in the Ginkgo Collaboration Agreement.

 

III.        Section
2.2(d) (“Term Loan – Payment”) of the LSA is hereby deleted in its entirety and the following is substituted
therefor:

 

    

     

    

 

“Payment. Borrower will pay interest on each
Term Loan Advance on the first Business Day of each month, beginning the month after the (i) Closing Date with respect to the
Closing Date Term Loan Advance, (ii) First Amendment Effective Date with respect to the Additional Term Loan Advance and
(iii) the Third Amendment Effective Date for the Third Amendment Term Loan Advance. At its sole discretion, Lender will
either (i) initiate debit entries to the Borrower’s account as authorized on the ACH Authorization on each payment date
of all periodic interest obligations payable to Lender under each Term Loan Advance and any costs and expenses reimbursable
to Lender, (ii) submit a written invoice to Borrower for all amounts due by Borrower on each payment date of all periodic
interest obligations payable to Lender under each Term Loan Advance and any costs and expenses reimbursable to Lender, which
invoice must be paid by Borrower within five days of receipt or (iii) submit other written instructions to Borrower regarding
the proper method for payment of such periodic interest obligations and costs and expenses. In addition, Borrower shall pay
to the Agent, for the benefit of Lender, (i) promptly following Parent’s receipt thereof, all Net Profits earned by and
actually received by Parent under the Ginkgo Collaboration Agreement, up to a maximum of $1,000,000 in any calendar month and
(ii) promptly following Parent’s receipt thereof, all Earned Incentive Payments and/or Incentive Payments earned by and
actually received by Parent that are owed by Ginkgo Bioworks, Inc. under the Ginkgo Collaboration Agreement, up to a maximum
of $3,000,000 in the aggregate, and in each case any such payments shall be applied to the principal balance outstanding
under the LSA on the first Business Day of the month following payment (except for any such payments that are received on the
first Business Day of the month, which shall be applied to the principal balance outstanding under the LSA on such date). For
the sake of clarification, any such payments of Net Profits, Earned Incentive Payments or Incentive Payments made to the
Agent, for the benefit of Lender, in accordance with this paragraph shall not be subject to any Prepayment Charge under
Section 2.5 hereof. The entire Term Loan Advance principal balance outstanding and all accrued but unpaid interest hereunder
shall be due and payable on the Term Loan Maturity Date. Borrower shall make all payments due under this Agreement
without setoff, recoupment or deduction and regardless of any counterclaim or defense.”

 

IV. The last paragraph of Section 7.1 (“Covenants
of Borrower - Financial Reports”) of the LSA is hereby deleted in its entirety and the following is substituted therefor:

 

“The executed Compliance Certificate
may be sent via e-mail to provided, that if e-mail is not available or sending the Compliance Certificate via email is not possible,
it shall be sent via facsimile to Agent at: , attention . All Financial Statements required to be delivered pursuant to clauses
(a), (b) and (c) shall be sent via e-mail to provided, that if e-mail is not available or sending such Financial Statements via
e-mail is not possible, they shall be sent via facsimile to Agent at: , attention .”

 

V. Sections 11.2(a), 11.2(b) and 11.2(c) (“Miscellaneous
- Notice”) of the LSA are hereby deleted in their entirety and the following is substituted therefor:

 

“(a) If to Agent:

 

STEGODON CORPORATION

Attention:

12 Saint Paul Street, #1

Cambridge, MA 02139

Email:

Facsimile:

 

(b)        If to Lender:

 

STEGODON CORPORATION

Attention:

12 Saint Paul Street, #1

Cambridge, MA 02139

Email:

 

Facsimile:

 

    
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(c) If to Borrower:

 

AMYRIS, INC.

Attention: General Counsel

5885 Hollis Street, Suite 100

Emeryville, CA 94608

Facsimile: ”

 

Within five (5) days following receipt of an invoice, Borrower shall
pay the Agent’s reasonable out-of-pocket costs, including reasonable attorneys’ fees, incurred in connection with the
LSA.

 

Except to the extent of this Amendment, the LSA shall remain unaltered
and in full force and effect. This Amendment shall not be a waiver of any existing default or breach of a covenant unless specified
herein.

 

This Amendment shall be limited precisely as written and shall not
be deemed (a) to be a waiver or modification of any other term or condition of the LSA or of any other instrument or agreement
referred to therein or to prejudice any right or remedy which Lender may now have or may have in the future under or in connection
with the LSA or any instrument or agreement referred to therein; or (b) to be a consent to any future amendment or modification
of any instrument or agreement the execution and delivery of which is consented to hereby, or to any waiver of any of the provisions
thereof.

 

The Borrower acknowledges and agrees that it remains obligated to
pay all principal, interest, reimbursement obligations, fees, and other amounts owing to the Agent and Lender under and in respect
of the Loan Documents when due and payable in accordance with the terms thereof.

 

The Borrower hereby acknowledges and agrees that as of the date
hereof, the Borrower has outstanding Secured Obligations to the Agent and the Lender which include indebtedness to the Agent and
Lender in an aggregate outstanding principal amount equal to $28,565,748.86 plus accrued interest and fees. The Borrower hereby
acknowledges and agrees that, to the best of its knowledge as of the date hereof, the liens and security interests granted in favor
of the Agent and/or the Lender under the terms of the Loan Documents are perfected, effective, enforceable, and valid and such
liens and security interests are, in each case, a first priority lien and security interest subject to Permitted Liens. Notwithstanding
the foregoing, each of the Agent and the Lender acknowledges and agrees that Borrower is not responsible for perfecting or ensuring
such liens are effective and enforceable.

 

The Borrower hereby acknowledges and agrees that as of the
date hereof: (a) it does not have any claim or cause of action related to the LSA, the Loan Documents or any other agreement
between or among Borrower, the Agent and/or the Lender against the Agent or the Lender (or any of their respective directors,
officers, employees, agents, subsidiaries, affiliates, attorneys, attorneys’ consultants, predecessors, successors or
assigns); (b) it does not have any offset right, counterclaim, or defense of any kind against the Secured Obligations or any
portion thereof; and (c) each of the Agent and the Lender has heretofore properly performed and satisfied in a timely manner
all of its obligations and commitments to the Borrower. For and in consideration of the agreements contained in this
Amendment and other good and valuable consideration, the Borrower unconditionally and irrevocably releases, waives, and
forever discharges each of the Agent and the Lender, together with their respective predecessors, successors, assigns,
subsidiaries, affiliates, agents, employees, directors, officers, attorneys and attorneys’ consultants (collectively,
the “Released Parties”), from the following, in each case only as related to the LSA, the Loan
Documents and any other agreement between or among Borrower, the Agent and/or the Lender: (x) any and all liabilities,
obligations, duties, promises, or indebtedness of any kind (if any) of the Released Parties to the Borrower or any of its
affiliates, which existed, arose, or occurred at any time from the beginning of the world to the date of this Amendment, and
(y) all claims, offsets, causes of action, suits, or defenses of any kind whatsoever (if any), which the Borrower or any of
its affiliates might otherwise have against the Released Parties, or any of them, in either case (x) or (y) on account of any
condition, act, omission, event, contract, liability, obligation, indebtedness, claim, cause of action, defense,
circumstance, or matter of any kind, which existed, arose, or occurred at any time from the beginning of the world to the
date of this Amendment. Notwithstanding anything to the contrary herein, the Borrower does not hereby release, waive, or
forever discharge the Released Parties from any claims, offsets, causes of action, suits or defenses of any kind relating
to any conduct or action by the Agent or Lender that is illegal under federal, state or local law.

 

    
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Without limitation, each party hereto acknowledges that it has been
advised by its attorneys concerning, and is familiar with, the California Civil Code Section 1542. Section 1542 of the California
Civil Code provides as follows:

 

A general release does not extend to claims which the creditor does
not know or suspect to exist in his or her favor at the time of the executing of the release, which if known by him or her must
have materially affected his or her settlement with the debtor.

 

Each party hereto expressly waives any and all rights under California
Civil Code Section 1542 and under any other federal or state statute or law of similar effect as to all matters released pursuant
to this Amendment.

 

This Amendment shall become effective upon the receipt of a fully
executed Amendment.

 

This Amendment may be executed in two or more counterparts, each
of which shall constitute an original, but all of which, when taken together, shall constitute but one instrument, and shall become
effective when one or more counterparts have been signed by each party hereto and delivered to the other party. Facsimile signatures
shall be deemed originals for all purposes hereunder. This Amendment shall be governed by, and construed and enforced in accordance
with, the laws of the State of California, excluding conflict of laws principles that would cause the application of laws of any
other jurisdiction.

 

[REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK]

 

 

 

    
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IN WITNESS WHEREOF, Borrower, the Agent and the Lender have
duly executed and delivered this Amendment as of the day and year first above written.

 

	 	AGENT AND LENDER:	 
	 	STEGODON CORPORATION, as Agent and as	 
	 	 	 	 
	 	AGENT AND LENDER	 
	 	 	 	 
	 	STEGODON CORPORATION, as Agent and as	 
	 	Lender	 
	 	 	 	 
	 	Signature:	/s/ Austin Che	 
	 	Print Name:	Austin Che	 
	 	Title:	President	 
	 	 	 	 
	 	BORROWER	 
	 	 	 	 
	 	AMYRIS, INC.	 
	 	 	 	 
	 	Signature:	 	 
	 	Print Name:	 	 
	 	Title:	 	 
	 	 	 	 
	 	AMYRIS FUELS, INC.	 
	 	 	 	 
	 	By Amyris, Inc., its sole manager 

	 
	 	 	 	 
	 	Signature:	 	 
	 	Print Name:	 	 
	 	Title:	 	 

 

 

    
[Signature Page to LSA Amendment]

     

    

 

IN WITNESS WHEREOF, Borrower, the Agent and the Lender have
duly executed and delivered this Amendment as of the day and year first above written.

 

		AGENT AND LENDER:	 
	 	STEGODON CORPORATION, as Agent and as	 
	 	 	 	 
	 	AGENT AND LENDER	 
	 	 	 	 
	 	STEGODON CORPORATION, as Agent and as	 
	 	Lender	 
	 	 	 	 
	 	Signature:		 
	 	Print Name:		 
	 	Title:		 
	 	 	 	 
	 	BORROWER	 
	 	 	 	 
	 	AMYRIS, INC.	 
	 	 	 	 
	 	Signature:	/s/ John Melo	 
	 	Print Name:	John Melo	 
	 	Title:	President and CEO	 
	 	 	 	 
	 	AMYRIS FUELS, INC.	 
	 	 	 	 
	 	By Amyris, Inc., its sole manager 

	 
	 	 	 	 
	 	Signature:	/s/ John Melo	 
	 	Print Name:	John Melo	 
	 	Title:	President and CEO	

 

 

 

[Signature Page to LSA Amendment]

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