Document:

Exhibit 10.7

 

ARYA
Sciences Acquisition Corp.

c/o Perceptive Advisors

51
Astor Place, 10th Floor,

New
York, NY 10003

 

July
5, 2018

 

ARYA
Sciences Holdings

c/o
Perceptive Advisors

51 Astor Place, 10th Floor

New
York, NY 10003

 

	RE:	Securities Subscription Agreement

 

Gentlemen:

 

This
agreement (this “Agreement”) is entered into on July 5, 2018 by and between ARYA Sciences Holdings, a Cayman
Islands exempted company (the “Subscriber” or “you”), and ARYA Sciences Acquisition Corp.,
a Cayman Islands exempted company (the “Company”). Pursuant to the terms hereof, the Company hereby accepts
the offer the Subscriber has made to purchase 3,593,750 Class B ordinary shares, $0.0001 par value per share (the “Shares”),
up to 468,750 of which are subject to forfeiture by you if the underwriters of the initial public offering (“IPO”)
of units (“Units”) of the Company do not fully exercise their over-allotment option (the “Over-allotment
Option”). The Company and the Subscriber’s agreements regarding such Shares are as follows:

 

1.
Purchase of Securities.

 

1.1
Purchase of Shares. For the sum of $25,000 (the “Purchase Price”), which the Company acknowledges receiving
in cash, the Company hereby issues the Shares to the Subscriber, and the Subscriber hereby purchases the Shares from the Company,
468,750 of which are subject to forfeiture, on the terms and subject to the conditions set forth in this Agreement. All references
in this Agreement to shares of the Company being forfeited shall take effect as surrenders for no consideration of such shares
as a matter of Cayman Islands law.

 

1.2
Transfer of Shares. On or about the date of this Agreement, Ogier Global (Subscriber) Limited, being the holder of 100
Class B ordinary shares of $0.0001 par value has transferred all of the shares standing in its name in the register of members
of the Company to hold the same unto the Subscriber, and such shares shall form part of the Shares to be issued to Subscriber
hereunder.

 

2.
Representations, Warranties and Agreements.

 

2.1
Subscriber’s Representations, Warranties and Agreements. To induce the Company to issue the Shares to the Subscriber,
the Subscriber hereby represents and warrants to the Company and agrees with the Company as follows:

 

2.1.1
No Government Recommendation or Approval. The Subscriber understands that no federal or state agency has passed upon or
made any recommendation or endorsement of the offering of the Shares.

 

    

    

    

 

2.1.2
No Conflicts. The execution, delivery and performance of this Agreement and the consummation by the Subscriber of the transactions
contemplated hereby do not violate, conflict with or constitute a default under (i) the memorandum and articles of association
of the Subscriber, (ii) any agreement, indenture or instrument to which the Subscriber is a party or (iii) any law, statute, rule
or regulation to which the Subscriber is subject, or any agreement, order, judgment or decree to which the Subscriber is subject.

 

2.1.3
Registration and Authority. The Subscriber is a Cayman Islands exempted company, validly existing and possessing all requisite
power and authority necessary to carry out the transactions contemplated by this Agreement. Upon execution and delivery by you,
this Agreement will be a legal, valid and binding agreement of Subscriber, enforceable against Subscriber in accordance with its
terms, except as such enforceability may be limited by applicable bankruptcy, insolvency, fraudulent conveyance or similar laws
affecting the enforcement of creditors’ rights generally and subject to general principles of equity (regardless of whether
enforcement is sought in a proceeding at law or in equity).

 

2.1.4
Experience, Financial Capability and Suitability. Subscriber is: (i) sophisticated in financial matters and is able to
evaluate the risks and benefits of the investment in the Shares and (ii) able to bear the economic risk of its investment in the
Shares for an indefinite period of time because the Shares have not been registered under the Securities Act (as defined below)
and therefore cannot be sold unless subsequently registered under the Securities Act or an exemption from such registration is
available. Subscriber is capable of evaluating the merits and risks of its investment in the Company and has the capacity to protect
its own interests. Subscriber must bear the economic risk of this investment until the Shares are sold pursuant to: (i) an effective
registration statement under the Securities Act or (ii) an exemption from registration available with respect to such sale. Subscriber
is able to bear the economic risks of an investment in the Shares and to afford a complete loss of Subscriber’s investment
in the Shares.

 

2.1.5
Access to Information; Independent Investigation. Prior to the execution of this Agreement, the Subscriber has had
the opportunity to ask questions of and receive answers from representatives of the Company concerning an investment in the Company,
as well as the finances, operations, business and prospects of the Company, and the opportunity to obtain additional information
to verify the accuracy of all information so obtained. In determining whether to make this investment, Subscriber has relied solely
on Subscriber’s own knowledge and understanding of the Company and its business based upon Subscriber’s own due diligence
investigation and the information furnished pursuant to this paragraph. Subscriber understands that no person has been authorized
to give any information or to make any representations which were not furnished pursuant to this Section 2 and Subscriber has
not relied on any other representations or information in making its investment decision, whether written or oral, relating to
the Company, its operations and/or its prospects.

 

2.1.6
Regulation D Offering. Subscriber represents that it is an “accredited investor” as such term is defined in
Rule 501(a) of Regulation D under the Securities Act of 1933, as amended (the “Securities Act”) and acknowledges
the sale contemplated hereby is being made in reliance on a private placement exemption to “accredited investors”
within the meaning of Section 501(a) of Regulation D under the Securities Act or similar exemptions under federal and state law.

 

2.1.7
Investment Purposes. The Subscriber is purchasing the Shares solely for investment purposes, for the Subscriber’s
own account and not for the account or benefit of any other person, and not with a view towards the distribution or dissemination
thereof. The Subscriber did not decide to enter into this Agreement as a result of any general solicitation or general advertising
within the meaning of Rule 502 under the Securities Act.

 

    2

    

    

 

2.1.8 
Restrictions on Transfer; Shell Company. Subscriber understands the Shares are being offered in a transaction not
involving a public offering within the meaning of the Securities Act. Subscriber understands the Shares will be “restricted
securities” within the meaning of Rule 144(a)(3) under the Securities Act, and Subscriber understands that the certificates
representing the Shares will contain a legend in respect of such restrictions. If in the future the Subscriber decides to offer,
resell, pledge or otherwise transfer the Shares, such Shares may be offered, resold, pledged or otherwise transferred only pursuant
to: (i) registration under the Securities Act, or (ii) an available exemption from registration. Subscriber agrees that if any
transfer of its Shares or any interest therein is proposed to be made, as a condition precedent to any such transfer, Subscriber
may be required to deliver to the Company an opinion of counsel satisfactory to the Company. Absent registration or an exemption,
the Subscriber agrees not to resell the Shares. Subscriber further acknowledges that because the Company is a shell company, Rule
144 may not be available to the Subscriber for the resale of the Shares until one year following consummation of the initial business
combination of the Company, despite technical compliance with the requirements of Rule 144 and the release or waiver of any contractual
transfer restrictions.

 

2.1.9
No Governmental Consents. No governmental, administrative or other third party consents or approvals are required or necessary
on the part of Subscriber in connection with the transactions contemplated by this Agreement.

 

2.2
Company’s Representations, Warranties and Agreements. To induce the Subscriber to purchase the Shares, the Company
hereby represents and warrants to the Subscriber and agrees with the Subscriber as follows:

 

2.2.1
Incorporation and Corporate Power. The Company is a Cayman Islands exempted company and is qualified to do business in
every jurisdiction in which the failure to so qualify would reasonably be expected to have a material adverse effect on the financial
condition, operating results or assets of the Company. The Company possesses all requisite corporate power and authority necessary
to carry out the transactions contemplated by this Agreement. Upon execution and delivery by the Company, this Agreement will
be a legal, valid and binding agreement of the Company, enforceable against the Company in accordance with its terms, except as
such enforceability may be limited by applicable bankruptcy, insolvency, fraudulent conveyance or similar laws affecting the enforcement
of creditors’ rights generally and subject to general principles of equity (regardless of whether enforcement is sought
in a proceeding at law or in equity).

 

2.2.2
No Conflicts. The execution, delivery and performance of this Agreement and the consummation by the Company of the transactions
contemplated hereby do not violate, conflict with or constitute a default under (i) the memorandum and articles of association
of the Company, (ii) any agreement, indenture or instrument to which the Company is a party or (iii) any law, statute, rule or
regulation to which the Company is subject, or any agreement, order, judgment or decree to which the Company is subject.

 

2.2.3
Title to Securities. Upon issuance in accordance with, and payment pursuant to, the terms hereof, and registration in the
Company’s register of members, the Shares will be duly and validly issued, fully paid and nonassessable. Upon issuance in
accordance with, and payment pursuant to, the terms hereof, and registration in the Company’s register of members, the Subscriber
will have or receive good title to the Shares, free and clear of all liens, claims and encumbrances of any kind, other than (a)
transfer restrictions hereunder and other agreements to which the Shares may be subject, (b) transfer restrictions under federal
and state securities laws, and (c) liens, claims or encumbrances imposed due to the actions of the Subscriber.

 

2.2.4
No Adverse Actions. There are no actions, suits, investigations or proceedings pending, threatened against or affecting
the Company which: (i) seek to restrain, enjoin, prevent the consummation of or otherwise affect the transactions contemplated
by this Agreement or (ii) question the validity or legality of any transactions or seeks to recover damages or to obtain other
relief in connection with any transactions.

 

    3

    

    

 

3.
Forfeiture of Shares.

 

3.1
Partial or No Exercise of the Over-allotment Option. In the event the Over-allotment Option granted to the representative(s)
of the underwriters of the Company’s IPO is not exercised in full, the Subscriber acknowledges and agrees that it shall
forfeit any and all rights to such number of Shares (up to an aggregate of 468,750 Shares and pro rata based upon the percentage
of the Over-allotment Option exercised) such that immediately following such forfeiture, the Subscriber (and all other initial
shareholders prior to the IPO, if any) will own an aggregate number of Shares (not including ordinary shares issuable upon exercise
of any warrants or any ordinary shares purchased by Subscriber in the Company’s IPO or in the aftermarket) equal to 20%
of the issued and outstanding ordinary shares of the Company immediately following the IPO.

 

3.2
Termination of Rights as Shareholder. If any of the Shares are forfeited in accordance with this Section 3, then after
such time the Subscriber (or successor in interest), shall no longer have any rights as a holder of such Shares, and the Company
shall take such action as is appropriate to cancel such Shares.

 

4.
Waiver of Liquidation Distributions; Redemption Rights. In connection with the Shares purchased pursuant to this Agreement,
the Subscriber hereby waives any and all right, title, interest or claim of any kind in or to any distributions by the Company
from the trust account which will be established for the benefit of the Company’s public shareholders and into which substantially
all of the proceeds of the IPO will be deposited (the “Trust Account”), in the event of a liquidation of the
Company upon the Company’s failure to timely complete an initial business combination. For purposes of clarity, in the event
the Subscriber purchases ordinary shares in the IPO or in the aftermarket, any additional Shares so purchased shall be eligible
to receive any liquidating distributions by the Company. However, in no event will the Subscriber have the right to redeem any
ordinary shares into funds held in the Trust Account upon the successful completion of an initial business combination.

 

5.
Restrictions on Transfer.

 

5.1
Securities Law Restrictions. In addition to any restrictions to be contained in that certain letter agreement (commonly
known as an “Insider Letter”) to be dated as of the closing of the IPO by and between Subscriber and the Company,
Subscriber agrees not to sell, transfer, pledge, hypothecate or otherwise dispose of all or any part of the Shares unless, prior
thereto (a) a registration statement on the appropriate form under the Securities Act and applicable state securities laws with
respect to the Shares proposed to be transferred shall then be effective or (b) the Company has received an opinion from counsel
reasonably satisfactory to the Company, that such registration is not required because such transaction is exempt from registration
under the Securities Act and the rules promulgated by the Securities and Exchange Commission thereunder and with all applicable
state securities laws.

 

5.2
Restrictive Legends. Any certificates representing the Shares shall have endorsed thereon legends substantially as follows:

 

“THE
SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED, OR ANY STATE
SECURITIES LAWS AND NEITHER THE SECURITIES NOR ANY INTEREST THEREIN MAY BE OFFERED, SOLD, TRANSFERRED, PLEDGED OR OTHERWISE DISPOSED
OF EXCEPT PURSUANT TO AN EFFECTIVE REGISTRATION STATEMENT UNDER SUCH ACT OR SUCH LAWS OR AN EXEMPTION FROM REGISTRATION UNDER
SUCH ACT AND SUCH LAWS WHICH, IN THE OPINION OF COUNSEL, IS AVAILABLE.”

 

“THE
SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO A LOCKUP AND MAY NOT BE OFFERED, SOLD, TRANSFERRED, PLEDGED OR OTHERWISE
DISPOSED DURING THE TERM OF THE LOCKUP.”

 

    4

    

    

 

5.3
Additional Shares or Substituted Securities. In the event of the declaration of a share dividend, the declaration of an
extraordinary dividend payable in a form other than Shares, a spin-off, a share split, an adjustment in conversion ratio, a recapitalization
or a similar transaction affecting the Company’s outstanding Shares without receipt of consideration, any new, substituted
or additional securities or other property which are by reason of such transaction distributed with respect to any Shares subject
to this Section 5 or into which such Shares thereby become convertible shall immediately be subject to this Section 5 and Section
3. Appropriate adjustments to reflect the distribution of such securities or property shall be made to the number and/or class
of Shares subject to this Section 5 and Section 3.

 

5.4
Registration Rights. Subscriber acknowledges that the Shares are being purchased pursuant to an exemption from the registration
requirements of the Securities Act and will become freely tradable only after certain conditions are met or they are registered
pursuant to a Registration Rights Agreement to be entered into with the Company prior to the closing of the IPO.

 

6.
Other Agreements.

 

6.1
Further Assurances. Subscriber agrees to execute such further instruments and to take such further action as may reasonably
be necessary to carry out the intent of this Agreement.

 

6.2
Notices. All notices, statements or other documents which are required or contemplated by this Agreement shall be: (i)
in writing and delivered personally or sent by first class registered or certified mail, overnight courier service or facsimile
or electronic transmission to the address designated in writing, (ii) by facsimile to the number most recently provided to such
party or such other address or fax number as may be designated in writing by such party and (iii) by electronic mail, to the electronic
mail address most recently provided to such party or such other electronic mail address as may be designated in writing by such
party. Any notice or other communication so transmitted shall be deemed to have been given on the day of delivery, if delivered
personally, on the business day following receipt of written confirmation, if sent by facsimile or electronic transmission, one
(1) business day after delivery to an overnight courier service or five (5) days after mailing if sent by mail.

 

6.3
Entire Agreement. This Agreement, together with that certain Insider Letter to be entered into between Subscriber and the
Company, substantially in the form to be filed as an exhibit to the Registration Statement on Form S-1 associated with the Company’s
IPO, embodies the entire agreement and understanding between the Subscriber and the Company with respect to the subject matter
hereof and supersedes all prior oral or written agreements and understandings relating to the subject matter hereof. No statement,
representation, warranty, covenant or agreement of any kind not expressly set forth in this Agreement shall affect, or be used
to interpret, change or restrict, the express terms and provisions of this Agreement.

 

6.4
Modifications and Amendments. The terms and provisions of this Agreement may be modified or amended only by written agreement
executed by all parties hereto.

 

    5

    

    

 

6.5
Waivers and Consents. The terms and provisions of this Agreement may be waived, or consent for the departure therefrom
granted, only by a written document executed by the party entitled to the benefits of such terms or provisions. No such waiver
or consent shall be deemed to be or shall constitute a waiver or consent with respect to any other terms or provisions of this
Agreement, whether or not similar. Each such waiver or consent shall be effective only in the specific instance and for the purpose
for which it was given, and shall not constitute a continuing waiver or consent.

 

6.6
Assignment. The rights and obligations under this Agreement may not be assigned by either party hereto without the prior
written consent of the other party.

 

6.7
Benefit. All statements, representations, warranties, covenants and agreements in this Agreement shall be binding on the
parties hereto and shall inure to the benefit of the respective successors and permitted assigns of each party hereto. Nothing
in this Agreement shall be construed to create any rights or obligations except among the parties hereto, and no person or entity
shall be regarded as a third-party beneficiary of this Agreement.

 

6.8
Governing Law. This Agreement and the rights and obligations of the parties hereunder shall be construed in accordance
with and governed by the laws of New York applicable to contracts wholly performed within the borders of such state, without giving
effect to the conflict of law principles thereof.

 

6.9
Severability. In the event that any court of competent jurisdiction shall determine that any provision, or any portion
thereof, contained in this Agreement shall be unreasonable or unenforceable in any respect, then such provision shall be deemed
limited to the extent that such court deems it reasonable and enforceable, and as so limited shall remain in full force and effect.
In the event that such court shall deem any such provision, or portion thereof, wholly unenforceable, the remaining provisions
of this Agreement shall nevertheless remain in full force and effect.

 

6.10
No Waiver of Rights, Powers and Remedies. No failure or delay by a party hereto in exercising any right, power or remedy
under this Agreement, and no course of dealing between the parties hereto, shall operate as a waiver of any such right, power
or remedy of such party. No single or partial exercise of any right, power or remedy under this Agreement by a party hereto, nor
any abandonment or discontinuance of steps to enforce any such right, power or remedy, shall preclude such party from any other
or further exercise thereof or the exercise of any other right, power or remedy hereunder. The election of any remedy by a party
hereto shall not constitute a waiver of the right of such party to pursue other available remedies. No notice to or demand on
a party not expressly required under this Agreement shall entitle the party receiving such notice or demand to any other or further
notice or demand in similar or other circumstances or constitute a waiver of the rights of the party giving such notice or demand
to any other or further action in any circumstances without such notice or demand.

 

6.11
Survival of Representations and Warranties. All representations and warranties made by the parties hereto in this Agreement
or in any other agreement, certificate or instrument provided for or contemplated hereby, shall survive the execution and delivery
hereof and any investigations made by or on behalf of the parties.

 

6.12
No Broker or Finder. Each of the parties hereto represents and warrants to the other that no broker, finder or other financial
consultant has acted on its behalf in connection with this Agreement or the transactions contemplated hereby in such a way as
to create any liability on the other. Each of the parties hereto agrees to indemnify and save the other harmless from any claim
or demand for commission or other compensation by any broker, finder, financial consultant or similar agent claiming to have been
employed by or on behalf of such party and to bear the cost of legal expenses incurred in defending against any such claim.

 

    6

    

    

 

6.13
Headings and Captions. The headings and captions of the various subdivisions of this Agreement are for convenience of reference
only and shall in no way modify or affect the meaning or construction of any of the terms or provisions hereof.

 

6.14
Counterparts. This Agreement may be executed in one or more counterparts, all of which when taken together shall be considered
one and the same agreement and shall become effective when counterparts have been signed by each party and delivered to the other
party, it being understood that both parties need not sign the same counterpart. In the event that any signature is delivered
by facsimile transmission or any other form of electronic delivery, such signature shall create a valid and binding obligation
of the party executing (or on whose behalf such signature is executed) with the same force and effect as if such signature page
were an original thereof.

 

6.15
Construction. The parties hereto have participated jointly in the negotiation and drafting of this Agreement. If an ambiguity
or question of intent or interpretation arises, this Agreement will be construed as if drafted jointly by the parties hereto and
no presumption or burden of proof will arise favoring or disfavoring any party hereto because of the authorship of any provision
of this Agreement. The words “include,” “includes,” and “including” will
be deemed to be followed by “without limitation.” Pronouns in masculine, feminine, and neuter genders will
be construed to include any other gender, and words in the singular form will be construed to include the plural and vice versa,
unless the context otherwise requires. The words “this Agreement,” “herein,” “hereof,”
“hereby,” “hereunder,” and words of similar import refer to this Agreement as a whole and
not to any particular subdivision unless expressly so limited. The parties hereto intend that each representation, warranty, and
covenant contained herein will have independent significance. If any party hereto has breached any representation, warranty, or
covenant contained herein in any respect, the fact that there exists another representation, warranty or covenant relating to
the same subject matter (regardless of the relative levels of specificity) which such party hereto has not breached will not detract
from or mitigate the fact that such party hereto is in breach of the first representation, warranty, or covenant.

 

6.16
Mutual Drafting. This Agreement is the joint product of the Subscriber and the Company and each provision hereof has been
subject to the mutual consultation, negotiation and agreement of such parties and shall not be construed for or against any party
hereto.

 

7.
Voting and Tender of Shares. Subscriber agrees to vote the Shares in favor of an initial business combination that the
Company negotiates and submits for approval to the Company’s shareholders and shall not seek redemption with respect to
such Shares. Additionally, the Subscriber agrees not to tender any Shares in connection with a tender offer presented to the Company’s
shareholders in connection with an initial business combination negotiated by the Company.

 

[Signature
Page Follows]

 

    7

    

    

 

If
the foregoing accurately sets forth our understanding and agreement, please sign the enclosed copy of this Agreement and return
it to us.

 

	 	Very truly yours,
	 	 	 
	 	ARYA SCIENCES ACQUISITION CORP.
	 	 	 
	 	By:	/s/ James Mannix
	 	 	Name: James Mannix
	 	 	Title: Secretary

 

Accepted
and agreed as of the date first written above.

 

ARYA
SCIENCES HOLDINGS

 

	By:	/s/
    James Mannix	 
	 	Name: James Mannix	 
	 	Title: SecretaryExhibit 10.8

 

[●], 2018

 

ARYA Sciences Acquisition Corp.

51 Astor Place, 10th Floor

New York, NY 10003

 

Jefferies LLC

520 Madison Avenue, 2nd Floor

New York, NY 10022

Re: Initial Public Offering

 

Ladies and Gentlemen:

 

This letter (the “Letter Agreement”)
is being delivered to you in accordance with the Underwriting Agreement (the “Underwriting Agreement”)
entered into by and between ARYA Sciences Acquisition Corp., a Cayman Islands exempted company (the “Company”)
and Jefferies LLC as representative (the “Representative”) of the several underwriters named in Schedule
A thereto (the “Underwriters”), relating to an underwritten initial public offering (the “IPO”)
of the Company’s units (the “Units”), each unit comprised of one Class A ordinary share of the
Company, par value $0.0001 per share (the “Class A Ordinary Shares”), and one-half of one redeemable
warrant, each whole warrant exercisable for one Class A Ordinary Share (each, a “Warrant”). Certain capitalized
terms used herein are defined in paragraph 12 hereof.

 

In order to induce the Company and the
Underwriters to enter into the Underwriting Agreement and to proceed with the IPO, and in recognition of the benefit that such
IPO will confer upon the undersigned as a shareholder of the Company, and for other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the undersigned hereby agrees with the Company as follows:

 

	1.	If the Company solicits approval of its shareholders of a Business Combination, the undersigned
will vote all shares beneficially owned by it, whether acquired before, in or after the IPO, in favor of such Business Combination.

 

	2.	In the event that the Company fails to consummate a Business Combination within the time
                                 period set forth in the Company’s amended and restated memorandum and articles of association, as the same may be
                                 further amended from time to time (the “Charter”), the undersigned will, as promptly as possible,
                                 take all necessary actions to cause the Company to (i) cease all operations except for the purpose of winding up, (ii) as
                                 promptly as reasonably possible, but not more than 10 business days thereafter, redeem the IPO Shares, at a per-share price,
                                 payable in cash, equal to the aggregate amount then on deposit in the Trust Account, including interest earned on the Trust
                                 Account not previously released to the Company (less taxes payable and up to $100,000 of such net interest to pay
                                 dissolution                                  expenses), divided by the number of then outstanding IPO Shares, which
                                 redemption will completely extinguish public                                  shareholders’ rights as shareholders
                                 (including the right to receive further liquidation distributions, if any), and                                  (iii) as
                                 promptly as reasonably possible following such redemption, subject to the approval of the Company’s remaining
                                 shareholders and the Company’s board of directors, dissolve and liquidate, subject in the cases of clauses (ii) and
                                 (iii) to the Company’s obligations under Cayman Islands law to provide for claims of creditors and other requirements
                                 of applicable law. The undersigned hereby waives any and all right, title, interest or claim of any kind in or to any
                                 distribution of the Trust Account and any remaining net assets of the Company as a result of such liquidation with respect
                                 to                                  the Founder Shares owned by the undersigned. However, if the undersigned has acquired IPO
                                 Shares in or after the IPO, it will                                  be entitled to liquidating distributions from the Trust
                                 Account with respect to such IPO Shares in the event that the Company                                  fails to consummate a
                                 Business Combination within the time period set forth in the Charter. In the event of the liquidation
                                 of the Trust Account, the undersigned agrees that it will be liable to the Company if and to the extent any claims by a
                                 third                                  party (other than the Company’s independent registered public accounting firm)
                                 for services rendered or products sold                                  to the Company, or a prospective target business with
                                 which the Company has discussed entering into a transaction agreement,                                  reduce the amount of
                                 funds in the Trust Account to below the lesser of (i) $10.00 per IPO Share and (ii) the actual amount
                                 per IPO Share held in the Trust Account as of the date of the liquidation of the Trust Account, if less than $10.00 per IPO
                                 Share                                  due to reductions in the value of the assets in the Trust Account, less taxes payable; provided
                                 that such                                  liability will not apply to any claims by a third party or prospective target
                                 business who executed a waiver of any and all                                  rights to the monies held in the Trust Account
                                 (whether or not such waiver is enforceable) nor will it apply to any claims                                  under the
                                 Company’s obligation to indemnify the Underwriters against certain liabilities, including liabilities under
                                 the Securities Act of 1933, as amended, pursuant to the Underwriting Agreement. The undersigned acknowledges and agrees that
                                 there will be no distribution from the Trust Account with respect to any Warrants, all rights of which will terminate on the
                                 Company’s liquidation.

 

    	 		 

     

    

 

	3.	The undersigned acknowledges and agrees that prior to entering into a definitive agreement for
a Business Combination with a target business that is affiliated with the undersigned or any other Insiders of the Company or their
affiliates, such transaction must be approved by a majority of the Company’s disinterested independent directors and the
Company must obtain an opinion from an independent investment banking firm, which is a member of the Financial Industry Regulatory
Authority, or an independent accounting firm that such Business Combination is fair to the Company’s unaffiliated shareholders
from a financial point of view.

 

	4.	Neither the undersigned nor any affiliate of the undersigned will be entitled to receive and will
not accept any compensation or other cash payment prior to, or for services rendered in order to effectuate, the consummation of
the Business Combination; provided that the Company shall be allowed to make the payments set forth in the Registration
Statement adjacent to the caption “Prospectus Summary—The Offering—Limited payments to insiders.”

 

	5.	(a)	The undersigned agrees that the Founder Shares may not be transferred, assigned or sold (except
to certain permitted transferees as described in the Registration Statement or herein) (the “Lockup”)
until the earlier to occur of: (1) one year after the completion of a Business Combination or (2) the date following the completion
of the Company’s initial Business Combination on which the Company completes a liquidation, merger, share exchange, reorganization
or other similar transaction that results in all of the Company’s shareholders having the right to exchange their Class A
Ordinary Shares for cash, securities or other property. Notwithstanding the foregoing, if the closing price of the Company’s
Class A Ordinary Shares equals or exceeds $12.00 per share (as adjusted for share splits, share capitalizations, reorganizations,
recapitalizations and the like) for any 20 trading days within any 30-trading day period commencing at least 150 days after the
Company’s initial Business Combination, the Founder Shares will be released from the Lockup.

 

    	 	2	 

     

    

 

		(b)	The undersigned will not, without the prior written consent of the Representative pursuant to the
Underwriting Agreement, offer, sell, contract to sell, pledge, hedge or otherwise dispose of (or enter into any transaction that
is designed to, or might reasonably be expected to, result in the disposition (whether by actual disposition or effective economic
disposition due to cash settlement or otherwise) by the undersigned or any affiliate of the undersigned or any person in privity
with the undersigned or any affiliate of the undersigned), directly or indirectly, including the filing (or participation in the
filing) of a registration statement with the Securities and Exchange Commission in respect of, or establish or increase a put equivalent
position or liquidate or decrease a call equivalent position within the meaning of Section 16 of the Securities Exchange Act of
1934, as amended, and the rules and regulations of the Securities and Exchange Commission promulgated thereunder with respect to,
any other Units, Class A Ordinary Shares or Warrants of the Company or any securities convertible into, or exercisable, or exchangeable
for, Class A Ordinary Shares or publicly announce an intention to effect any such transaction, for a period of 180 days after the
date of the Underwriting Agreement.

 

		(c)	The undersigned agrees that until the Company consummates an initial Business Combination, the
undersigned’s Private Placement Warrants will be subject to the transfer restrictions described in the Private Placement
Warrants Purchase Agreement relating to the undersigned’s Private Placement Warrants.

 

		(d)	Notwithstanding the provisions set forth in paragraphs 5(a) and (c), transfers, assignments and
sales by the undersigned of the Founder Shares, Private Placement Warrants and Class A Ordinary Shares issued or issuable upon
the exercise of the Private Placement Warrants or conversion of the Founder Shares are permitted (i) to the Company’s officers
or directors, any affiliates or family members of any of the Company’s officers or directors, any members or partners of
the undersigned or their affiliates, or any affiliates of the undersigned; (ii) in the case of an individual, by gift to a member
of the individual’s immediate family or to a trust, the beneficiary of which is a member of one of the individual’s
immediate family, an affiliate of such person or to a charitable organization; (iii) in the case of an individual, by virtue of
laws of descent and distribution upon death of the individual; (iv) in the case of an individual, pursuant to a qualified domestic
relations order; (v) by private sales or transfers made in connection with the consummation of the Business Combination at prices
no greater than the price at which the Founder Shares, Private Placement Warrants or Class A Ordinary Shares were originally purchased,
as applicable; (vi) by virtue of the undersigned’s organizational documents upon liquidation or dissolution of the undersigned;
(vii) to the Company for no value for cancellation in connection with the consummation of the Business Combination; (viii) in the
event of the Company’s liquidation prior to the completion of a Business Combination; or (ix) in the event of completion
of a liquidation, merger, share exchange or other similar transaction which results in all of the Company’s shareholders
having the right to exchange their Class A Ordinary Shares for cash, securities or other property subsequent to the completion
of a Business Combination; provided, however, that in the case of clauses (i) through (vi) these permitted transferees
must enter into a written agreement agreeing to be bound by the restrictions herein.

 

    	 	3	 

     

    

 

	6.	(a)	In order to minimize potential conflicts of interest that may arise from multiple
                                      corporate affiliations, the undersigned hereby agrees that until the earliest of the Company’s initial Business
                                      Combination or liquidation, the undersigned shall present to the Company for its consideration, prior to presentation to any
                                      other entity, any target business that has a fair market value of at least 80% of the assets held in the Trust Account
                                      (excluding the amount of deferred underwriting discounts held in trust and taxes payable on the interest earned on the trust
                                      account),                                       subject                                       to
                                      any                                                                  existing
                                      or                                                                             future
                                      fiduciary or                                                       contractual obligations the
                                      undersigned might have.

 

		(b)	The undersigned hereby agrees and acknowledges that (i) each of the Underwriters and the Company
would be irreparably injured in the event of a breach of the obligations under paragraph 6(a) above, (ii) monetary damages may
not be an adequate remedy for such breach and (iii) the non-breaching party shall be entitled to injunctive relief, in addition
to any other remedy that such party may have in law or in equity, in the event of such breach.

 

	7.	The undersigned has full right and power, without violating any agreement by which it is bound,
to enter into this Letter Agreement.

 

	8.	The undersigned hereby waives any right to exercise redemption rights with respect to any of the
Company’s ordinary shares owned or to be owned by the undersigned, directly or indirectly, whether such shares be part of
the Founder Shares or IPO Shares, and agrees not to seek redemption with respect to such shares (or sell such shares to the Company
in any tender offer) in connection with any vote to approve a Business Combination.

 

	9.	The undersigned hereby agrees to not propose, or vote in favor of, an amendment to Article [●]
of the Charter prior to the consummation of a Business Combination unless the Company provides public shareholders with the opportunity
to redeem their Class A Ordinary Shares upon such approval in accordance with such Article [●] thereof.

 

	10.	The undersigned agrees not to participate in the formation of any other blank check company (excluding
existing affiliations), until the Company has entered into a definitive agreement with respect to an initial Business Combination
or the Company has failed to complete an initial Business Combination within the time period set forth in the Charter.

 

	11.	This Letter Agreement shall be governed by and construed and enforced in accordance with the laws
of the State of New York, without giving effect to conflicts of law principles that would result in the application of the substantive
laws of another jurisdiction. The undersigned hereby (i) agrees that any action, proceeding or claim against him arising out of
or relating in any way to this Letter Agreement shall be brought and enforced in the courts of the State of New York of the United
States of America for the Southern District of New York, and irrevocably submits to such jurisdiction, which jurisdiction shall
be exclusive and (ii) waives any objection to such exclusive jurisdiction and that such courts represent an inconvenient forum.

 

    	 	4	 

     

    

 

	12.	As used herein, (i) a “Business Combination” shall mean a merger, share
exchange, asset acquisition, stock purchase, recapitalization, reorganization or other similar business combination with one or
more businesses or entities; (ii) “Insiders” shall mean all officers, directors and sponsors of the Company
immediately prior to the IPO; (iii) “Founder Shares” shall mean all of the Class B Ordinary Shares of
the Company acquired by an Insider prior to the IPO; (iv) “IPO Shares” shall mean the Class A Ordinary
Shares issued in the Company’s IPO; (v) “Private Placement Warrants” shall mean the warrants that
are being sold privately by the Company simultaneously with the consummation of the IPO; (vi) “Trust Account”
shall mean the trust account into which the net proceeds of the Company’s IPO and a portion of the proceeds from the sale
of the Private Placement Warrants will be deposited; and (vii) “Registration Statement” means the Company’s
registration statement on Form S-1 (SEC File No. 333-[●]) filed with the Securities and Exchange Commission, as amended.

 

	13.	This Letter Agreement constitutes the entire agreement and understanding of the parties hereto
in respect of the subject matter hereof and supersedes all prior understandings, agreements, or representations by or among the
parties hereto, written or oral, to the extent they relate in any way to the subject matter hereof or the transactions contemplated
hereby. This Letter Agreement may not be changed, amended, modified or waived (other than to correct a typographical error) as
to any particular provision, except by a written instrument executed by all parties hereto.

 

	14.	The undersigned acknowledges and understands that the Underwriters and the Company will rely upon
the agreements, representations and warranties set forth herein in proceeding with the IPO. Nothing contained herein shall be deemed
to render any Underwriter a representative of, or a fiduciary with respect to, the Company, its shareholders or any creditor or
vendor of the Company with respect to the subject matter hereof.

 

	15.	This Letter Agreement shall be binding on the undersigned and such person’s respective successors,
heirs, personal representatives and assigns. This Letter Agreement shall terminate on the earlier of (i) the consummation of a
Business Combination and (ii) the liquidation of the Company; provided, that such termination shall not relieve the undersigned
from liability for any breach of this agreement prior to its termination. The parties hereto may not assign either this Letter
Agreement or any of their rights, interests, or obligations hereunder without the prior written consent of the other party. Any
purported assignment in violation of this paragraph shall be void and ineffectual and shall not operate to transfer or assign any
interest or title to the purported assignee.

 

[Signature Page Follows]

 

    	 	5	 

     

    

 

	 	ARYA SCIENCES HOLDINGS
	 	 	 
	 	By:	                      
	 	Name:	 
	 	Title:	 

 

	 	Acknowledged and Agreed:
	 	 
	 	ARYA
SCIENCES ACQUISITION CORP.
	 	 	 
	 	By:	                            
	 	Name: 	 
	 	Title:

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