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  Exhibit 4.1    
    

 
    SECOND AMENDED AND RESTATED
  INVESTORS' RIGHTS AGREEMENT    
    

 

 
 

  TABLE OF CONTENTS    
    

 

									
	 
	 	 
	 	 
	 	Page 	 
	 1.
	 	Definitions	 	 	1	 
	 2.
	 	 Registration Rights
	 	 	

3	 
	 
	 	 2.1
	 	 Demand Registration
	 	 	

3	 
	 
	 	 2.2
	 	 Company Registration
	 	 	

5	 
	 
	 	 2.3
	 	 Underwriting Requirements
	 	 	

5	 
	 
	 	 2.4
	 	 Obligations of the Company
	 	 	

6	 
	 
	 	 2.5
	 	 Furnish Information
	 	 	

7	 
	 
	 	 2.6
	 	 Expenses of Registration
	 	 	

8	 
	 
	 	 2.7
	 	 Delay of Registration
	 	 	

8	 
	 
	 	 2.8
	 	 Indemnification
	 	 	

8	 
	 
	 	 2.9
	 	 Reports Under Exchange Act
	 	 	

10	 
	 
	 	 2.10
	 	 Limitations on Subsequent Registration Rights
	 	 	

10	 
	 
	 	 2.11
	 	 "Market Stand-off" Agreement
	 	 	

11	 
	 
	 	 2.12
	 	 Restrictions on Transfer
	 	 	

11	 
	 
	 	 2.13
	 	 Termination of Registration Rights
	 	 	

12	 
	 3.
	 	 Information and Observer Rights
	 	 	

13	 
	 
	 	 3.1
	 	 Delivery of Financial Statements
	 	 	

13	 
	 
	 	 3.2
	 	 Inspection
	 	 	

14	 
	 
	 	 3.3
	 	 Observer Rights
	 	 	

14	 
	 
	 	 3.4
	 	 Termination of Information Rights
	 	 	

14	 
	 
	 	 3.5
	 	 Confidentiality
	 	 	

15	 
	 4.
	 	 Rights to Future Stock Issuances
	 	 	

15	 
	 
	 	 4.1
	 	 Right of First Offer
	 	 	

15	 
	 
	 	 4.2
	 	 Termination
	 	 	

16	 
	 5.
	 	 Additional Covenants
	 	 	

16	 
	 
	 	 5.1
	 	 Insurance
	 	 	

16	 
	 
	 	 5.2
	 	 Employee Agreements
	 	 	

17	 
	 
	 	 5.3
	 	 Employee Stock
	 	 	

17	 
	 
	 	 5.4
	 	 Qualified Small Business Stock
	 	 	

17	 
	 
	 	 5.5
	 	 Successor Indemnification
	 	 	

17	 
	 
	 	 5.6
	 	 Expenses of Counsel
	 	 	

17	 
	 
	 	 5.7
	 	 Indemnification Matters
	 	 	

18	 
	 
	 	 5.8
	 	 Right to Conduct Activities
	 	 	

18	 

 

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	 	Page 	 
	 
	 	 5.9
	 	 FCPA
	 	 	19	 
	 
	 	 5.10
	 	 FIRPTA
	 	 	

19	 
	 
	 	 5.11
	 	 Termination of Covenants
	 	 	

19	 
	 6.
	 	 Miscellaneous
	 	 	

19	 
	 
	 	 6.1
	 	 Successors and Assigns
	 	 	

19	 
	 
	 	 6.2
	 	 Governing Law
	 	 	

20	 
	 
	 	 6.3
	 	 Counterparts
	 	 	

20	 
	 
	 	 6.4
	 	 Titles and Subtitles
	 	 	

20	 
	 
	 	 6.5
	 	 Notices
	 	 	

20	 
	 
	 	 6.6
	 	 Amendments and Waivers
	 	 	

20	 
	 
	 	 6.7
	 	 Severability
	 	 	

21	 
	 
	 	 6.8
	 	 Aggregation of Stock
	 	 	

21	 
	 
	 	 6.9
	 	 Additional Investors
	 	 	

21	 
	 
	 	 6.10
	 	 Entire Agreement
	 	 	

21	 
	 
	 	 6.11
	 	 Dispute Resolution
	 	 	

21	 
	 
	 	 6.12
	 	 Waiver of Jury Trial
	 	 	

22	 
	 
	 	 6.13
	 	 Delays or Omissions
	 	 	

22	 
	 
	 	 6.14
	 	 Acknowledgment
	 	 	

22	 

 

 ii

 

 

 
 

  SECOND AMENDED AND RESTATED
  INVESTORS' RIGHTS AGREEMENT    
    

          THIS SECOND AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT (this "Agreement"), is
made as of the 11th day of July, 2014, by and among Cerecor Inc., a Delaware corporation (the "Company"), and each of the investors listed
on Schedule A hereto, each of which is referred to in this Agreement as an "Investor." 

 
 

RECITALS    
    

          WHEREAS, certain of the Investors (the "Existing
Investors") hold shares of the Company's Series A Preferred Stock, Series A-1 Preferred Stock and/or shares of Common Stock and possess certain rights pursuant to
an Amended and Restated Investors' Rights Agreement dated as of August 23, 2013 between the Company and such Investors (the "Prior Agreement");
and 

          WHEREAS, the Existing Investors are holders of a majority of the Registrable Securities of the Company (as defined in the Prior
Agreement), and desire to amend and restate the Prior Agreement in its entirety and to accept the rights and obligations created pursuant to this Agreement in lieu of the rights and obligations of the
Existing Investors under the Prior Agreement; and 

          WHEREAS, certain of the Investors are parties to that certain Series B Preferred Stock Purchase Agreement of even date herewith
between the Company and certain of the Investors (the "Purchase Agreement"), under which certain of the Company's and such Investors' obligations are
conditioned upon the execution and delivery of this Agreement by such Investors, Existing Investors holding a majority of the Registrable Securities, and the Company; 

          NOW, THEREFORE, the Existing Investors hereby agree that the Prior Agreement shall be amended and restated, and the parties to this
Agreement further agree as follows: 

 
 
          1.    Definitions.     For purposes of this Agreement: 

          1.1      "Affiliate" means, with respect to any specified Person, any other Person who, directly or indirectly, controls, is
controlled by, or is under common control with such Person, including without limitation any general partner, managing member, officer or director of such Person or any venture capital fund now or
hereafter existing that is controlled by one or more general partners or managing members of, or shares the same management company with, such Person. 

          1.2     "Common Stock" means shares of the Company's common stock, par value $0.001 per share. 

          1.3     "Damages" means any loss, damage, claim or liability (joint or several) to which a party hereto may become subject under
the Securities Act, the Exchange Act, or other federal or state law, insofar as such loss, damage, claim or liability (or any action in respect thereof) arises out of or is based upon: (i) any
untrue statement or alleged untrue statement of a material fact contained in any registration statement of the Company, including any preliminary prospectus or final prospectus contained therein or
any amendments or supplements thereto; (ii) an omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not
misleading; or (iii) any violation or alleged violation by the indemnifying party (or any of its agents or Affiliates) of the Securities Act, the Exchange Act, any state securities law, or any
rule or regulation promulgated under the Securities Act, the Exchange Act, or any state securities law. 

          1.4     "Derivative Securities" means any securities or rights convertible into, or exercisable or exchangeable for (in each
case, directly or indirectly), Common Stock, including options and warrants. 

1

 

          1.5     "Exchange Act" means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated
thereunder. 

          1.6     "Excluded Registration" means (i) a registration relating to the sale of securities to employees of the Company
or a subsidiary pursuant to a stock option, stock purchase, or similar plan; (ii) a registration relating to an SEC Rule 145 transaction; (iii) a registration on any form that
does not include substantially the same information as would be required to be included in a registration statement covering the sale of the Registrable Securities; or (iv) a registration in
which the only Common Stock being registered is Common Stock issuable upon conversion of debt securities that are also being registered. 

          1.7      "Form S-1" means such form under the Securities Act as in effect on the date hereof or any successor registration
form under the Securities Act subsequently adopted by the SEC. 

          1.8     "Form S-3" means such form under the Securities Act as in effect on the date hereof or any registration form
under the Securities Act subsequently adopted by the SEC that permits incorporation of substantial information by reference to other documents filed by the Company with the SEC. 

          1.9     "GAAP" means generally accepted accounting principles in the United States. 

          1.10    "Holder" means any holder of Registrable Securities who is a party to this Agreement. 

          1.11    "Immediate Family Member" means a child, stepchild, grandchild, parent, stepparent, grandparent, spouse, sibling,
mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law, or sister-in-law, including, adoptive relationships, of a natural person referred to herein. 

          1.12    "Initiating Holders" means, collectively, Holders who properly initiate a registration request under this Agreement. 

          1.13    "IPO" means the Company's first underwritten public offering of its Common Stock under the Securities Act. 

          1.14    "Major Investor" means any Investor that, individually or together with such Investor's Affiliates, holds at least ten
percent (10%) of the shares of Preferred Stock then outstanding. 

          1.15    "NEA" means New Enterprise Associates 14, Limited Partnership. 

          1.16    "New Securities" means, collectively, equity securities of the Company, whether or not currently authorized, as well as
rights, options, or warrants to purchase such equity securities, or securities of any type whatsoever that are, or may become, convertible or exchangeable into or exercisable for such equity
securities. 

          1.17    "Person" means any individual, corporation, partnership, trust, limited liability company, association or other entity. 

          1.18    "Preferred Stock" means, collectively, shares of Series A Preferred Stock, Series A-1 Preferred Stock and
Series B Preferred Stock. 

          1.19    "Qualified IPO" has the meaning given to such term in the Company's Amended and Restated Certificate of Incorporation,
as may be amended from time to time. 

          1.20   "Registrable Securities" means (i) the Common Stock issuable or issued upon conversion of the Preferred Stock,
excluding any Common Stock issued upon conversion of Preferred Stock pursuant to the "Special Mandatory Conversion" provisions of the Company's Certificate of Incorporation; (ii) any Common
Stock, or any Common Stock issued or issuable (directly or indirectly) upon conversion and/or exercise of any other securities of the Company, acquired by the Investors after the date hereof; and
(iii) any Common Stock issued as (or issuable upon the conversion or exercise of any warrant, right, or other security that is issued as) a dividend or other 

2

 

distribution
with respect to, or in exchange for or in replacement of, the shares referenced in clauses (i) and  (ii) above; excluding in all cases, however,
any Registrable Securities sold by a Person in a transaction in which the applicable rights under
this Agreement are not assigned pursuant to Section 6.1, and excluding for purposes of  Section 2 any shares for which registration rights have
terminated pursuant to  Section 2.13 of this Agreement. 

          1.21    "Registrable Securities then outstanding" means the number of shares determined by adding the number of shares of
outstanding Common Stock that are Registrable Securities and the number of shares of Common Stock issuable (directly or indirectly) pursuant to then exercisable and/or convertible securities that are
Registrable Securities. 

          1.22   "Restricted Securities" means the securities of the Company required to be notated with the legend set forth in  Section 2.12(b) hereof. 

          1.23   "SEC" means the Securities and Exchange Commission. 

          1.24   "SEC Rule 144" means Rule 144 promulgated by the SEC under the Securities Act. 

          1.25   "SEC Rule 145" means Rule 145 promulgated by the SEC under the Securities Act. 

          1.26   "Securities Act" means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder. 

          1.27    "Selling Expenses" means all underwriting discounts, selling commissions, and stock transfer taxes applicable to the
sale of Registrable Securities, and fees and disbursements of counsel for any Holder, except for the fees and disbursements of the Selling Holder Counsel borne and paid by the Company as provided in  Section 2.6. 

          1.28   "Series A Preferred Stock" means shares of the Company's Series A Preferred Stock, par value $0.001 per
share. 

          1.29   "Series A-1 Preferred Stock" means shares of the Company's Series A- Preferred Stock, par value $0.001
per share. 

          1.30   "Series B Director" means any director of the Company that the holders of Series B Preferred Stock are
entitled to elect pursuant to Section 1.2(a), Section 1.2(b), Section 1.2(c) or Section 1.2(d) of the Voting Agreement. 

          1.31    "Series B Preferred Stock" means shares of the Company's Series B Preferred Stock, par value $0.001 per
share. 

          1.32   "Voting Agreement" means the Second Amended and Restated Voting Agreement, dated as of the date hereof, by and among
the Company, certain of the Investors and the other parties thereto. 

 
 
          2.    Registration Rights.     The Company covenants and agrees as follows: 

 
 
           2.1    Demand Registration.
    

 
 
           (a)    Form S-1 Demand.
    If at any time after the earlier of (i) three (3) years after the date of this Agreement and (ii) one hundred eighty (180) days after the effective date of
the registration statement for the IPO, the Company receives a request from Holders of a majority of the shares of Series B Preferred Stock then outstanding (the
"Requisite Holders") that the Company file a Form S-1 registration statement with respect to Registrable Securities with an anticipated
aggregate offering price, net of Selling Expenses, of at least $10 million, then the Company shall (x) within ten (10) days after the date such request is given, give notice
thereof (the "Demand Notice") to all Holders other than the Initiating Holders; and (y) as soon as practicable, and in any event within sixty
(60) days after the date such request is given by the Initiating Holders, file a Form S-1 registration statement under the Securities 

3

 

Act
covering all Registrable Securities that the Initiating Holders requested to be registered and any additional Registrable Securities requested to be included in such registration by any other
Holders, as specified by notice given by each such Holder to the Company within twenty (20) days of the date the Demand Notice is given, and in each case, subject to the limitations
of Sections 2.1(c) and 2.3. 

 
 
           (b)    Form S-3 Demand.
    If at any time when it is eligible to use a Form S-3 registration statement, the Company receives a request from Holders of Registrable Securities that the Company file a
Form S-3 registration statement with respect to outstanding Registrable Securities of such Holders having an anticipated aggregate offering price, net of Selling Expenses, of at least
$1 million, then the Company shall (i) within ten (10) days after the date such request is given, give a Demand Notice to all Holders other than the Initiating Holders; and
(ii) as soon as practicable, and in any event within forty-five (45) days after the date such request is given by the Initiating Holders, file a Form S-3 registration
statement under the Securities Act covering all Registrable Securities requested to be included in such registration by any other Holders, as specified by notice given by each such Holder to the
Company within twenty (20) days of the date the Demand Notice is given, and in each case, subject to the limitations of Sections 2.1(c)  and 2.3.

          (c)     Notwithstanding
the foregoing obligations, if the Company furnishes to Holders requesting a registration pursuant to this  Section 2.1 a certificate signed by the Company's chief executive officer stating that in
the good faith judgment of the Company's Board of
Directors (including at least three Series B Directors) it would be materially detrimental to the Company and its stockholders for such registration statement to either become effective or
remain effective for as long as such registration statement otherwise would be required to remain effective, because such action would (i) materially interfere with a significant acquisition,
corporate reorganization, or other similar transaction involving the Company; (ii) require premature disclosure of material information that the Company has a bona fide business purpose for
preserving as confidential; or (iii) render the Company unable to comply with requirements under the Securities Act or Exchange Act, then the Company shall have the right to defer taking action
with respect to such filing for a period of not more than ninety (90) days after the request of the Initiating Holders is given; provided,  however,
that the Company may not invoke this right more than once in any twelve (12) month period; and provided
further that the Company shall not register any securities for its own account or that of any other stockholder during such ninety (90) day period other than an Excluded
Registration. 

          (d)     The
Company shall not be obligated to effect, or to take any action to effect, any registration pursuant to  Section 2.1(a)(i) during the period that is sixty (60) days before the Company's good
faith estimate of the date of filing of, and ending
on a date that is one hundred eighty (180) days after the effective date of, the registration statement filed in connection with the Company's IPO,  provided that the Company is actively employing
in good faith commercially reasonable efforts to cause such registration statement to become effective;
(ii) after the Company has effected two registrations pursuant to Section 2.1(a); or (iii) if the Initiating Holders propose to
dispose of shares of Registrable Securities that may be immediately registered on Form S-3 pursuant to a request made pursuant to  Section 2.1(b). The Company shall not be obligated to effect,
or to take any action to effect, any registration pursuant to  Section 2.1(b) (i) during the period that is thirty (30) days before the Company's good faith estimate of the date of filing
of,
and ending on a date that is ninety (90) days after the effective date of, a Company-initiated registration, provided that the Company is
actively employing in good faith commercially reasonable efforts to cause such registration statement to become effective; or (ii) if the Company has effected two registrations pursuant to  Section 2.1(b)
 within the twelve (12) month period immediately preceding the date of such 

4

 

request.
A registration shall not be counted as "effected" for purposes of this Section 2.1(d) until such time as the applicable registration
statement has been declared effective by the SEC, unless the Initiating Holders withdraw their request for such registration, elect not to pay the registration expenses therefor, and forfeit their
right to one demand registration statement pursuant to Section 2.6, in which case such withdrawn registration statement shall be counted as
"effected" for purposes of this Section 2.1(d). 

 
 
           2.2    Company Registration.
    If the Company proposes to register (including, for this purpose, a registration effected by the Company for stockholders other than the Holders) any of its Common Stock under the
Securities Act in connection with the public offering of such securities solely for cash (other than in an Excluded Registration), the Company shall, at such time, promptly give each Holder notice of
such registration. Upon the request of each Holder given within twenty (20) days after such notice is given by the Company, the Company shall, subject to the provisions
of Section 2.3, cause to be registered all of the Registrable Securities that each such Holder has requested to be included in such registration.
The Company shall have the right to terminate or withdraw any registration initiated by it under this Section 2.2 before the effective date of
such registration, whether or not any Holder has elected to include Registrable Securities in such registration. The expenses (other than Selling Expenses) of such withdrawn registration shall be
borne by the Company in accordance with Section 2.6. 

 
 
           2.3    Underwriting Requirements.
    

          (a)     If,
pursuant to Section 2.1, the Initiating Holders intend to distribute the Registrable Securities covered by
their request by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to Section 2.1, and the
Company shall include such information in the Demand Notice. The underwriter(s) will be selected by the Initiating Holders, subject only to the reasonable approval of the Company. In such event, the
right of any Holder to include such Holder's Registrable Securities in such registration shall be conditioned upon such Holder's participation in such underwriting and the inclusion of such Holder's
Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their securities through such underwriting shall (together with the Company as provided in  Section 2.4(e)
) enter into an underwriting agreement in customary form with the underwriter(s) selected for such underwriting. Notwithstanding
any other provision of this Section 2.3, if the managing underwriter(s) advise(s) the Initiating Holders in writing that marketing factors
require a limitation on the number of shares to be underwritten, then the Initiating Holders shall so advise all Holders of Registrable Securities that otherwise would be underwritten pursuant hereto,
and the number of Registrable Securities that may be included in the underwriting shall be allocated among such Holders of Registrable Securities, including the Initiating Holders, in proportion (as
nearly as practicable) to the number of Registrable Securities owned by each Holder or in such other proportion as shall mutually be agreed to by all such selling Holders;  provided, however, that the number of
Registrable Securities held by the Holders to be included in such underwriting shall not be reduced unless all other securities are first entirely excluded from the underwriting. To facilitate the
allocation of shares in accordance with the above provisions, the Company or the underwriters may round the number of shares allocated to any Holder to the nearest one hundred (100) shares. 

          (b)     In
connection with any offering involving an underwriting of shares of the Company's capital stock pursuant to  Section 2.2, the Company shall not be required to include any of the Holders' Registrable
Securities in such underwriting unless the Holders
accept the terms of the underwriting as agreed upon between the Company and its underwriters, and then only in such quantity as the underwriters in their sole discretion determine will not jeopardize
the success of the offering by the Company. If the total number of securities, including Registrable Securities, requested by stockholders to be included in such offering 

5

 

exceeds
the number of securities to be sold (other than by the Company) that the underwriters in their reasonable discretion determine is compatible with the success of the offering, then the Company
shall be required to include in the offering only that number of such securities, including Registrable Securities, which the underwriters and the Company in their sole discretion determine will not
jeopardize the success of the offering. If the underwriters determine that less than all of the Registrable Securities requested to be registered can be included in such offering, then the Registrable
Securities that are included in such offering shall be allocated among the selling Holders in proportion (as nearly as practicable to) the number of Registrable Securities owned by each selling Holder
or in such other proportions as shall mutually be agreed to by all such selling Holders. To facilitate the allocation of shares in accordance with the above provisions, the Company or the underwriters
may round the number of shares allocated to any Holder to the nearest one hundred (100) shares. Notwithstanding the foregoing, in no event shall (i) the number of Registrable Securities
included in the offering be reduced unless all other securities (other than securities to be sold by the Company and the Initiating Holders) are first entirely excluded from the offering,
(ii) the number of Registrable Securities included in the offering be reduced below twenty-five percent (25%) of the total number of securities included in such offering, unless such offering
is the IPO, in which case the selling Holders may be excluded further if the underwriters make the determination described above and no other stockholder's securities are included in such offering or
(iii) notwithstanding (ii) above, any Registrable Securities which are to be sold by Initiating Holders be excluded from such underwriting unless the Registrable Securities to be sold by
all other Holders are first excluded from such offering. For purposes of the provision in this Section 2.3(b) concerning apportionment, for any
selling Holder that is a partnership, limited liability company, or corporation, the partners, members, retired partners, retired members, stockholders, and Affiliates of such Holder, or the estates
and Immediate Family Members of any such partners, retired partners, members, and retired members and any trusts for the benefit of any of the foregoing Persons, shall be deemed to be a single
"selling Holder," and any pro rata reduction with respect to such "selling Holder" shall be based upon the aggregate number of Registrable Securities owned by all Persons included in such "selling
Holder," as defined in this sentence. 

          (c)     For
purposes of Section 2.1, a registration shall not be counted as "effected" if, as a result of an exercise of
the underwriter's cutback provisions in Section 2.3(a), fewer than fifty percent (50%) of the total number of Registrable Securities that Holders
have requested to be included in such registration statement are actually included. 

 
 
           2.4    Obligations of the Company.     Whenever required under this Section 2 to effect the registration of any Registrable Securities, the
Company shall, as expeditiously as reasonably possible: 

          (a)     prepare
and file with the SEC a registration statement with respect to such Registrable Securities and use its commercially reasonable efforts to cause such
registration statement to become effective and, upon the request of the Holders of a majority of the Registrable Securities registered thereunder, keep such registration statement effective for a
period of up to one hundred twenty (120) days or, if earlier, until the distribution contemplated in the registration statement has been completed;  provided, however, that (i) such one hundred twenty (120) day period shall be extended for
a period of time equal to the period the Holder refrains, at the request of an underwriter of Common Stock (or other securities) of the Company, from selling any securities included in such
registration, and (ii) in the case of any registration of Registrable Securities on Form S-3 that are intended to be offered on a continuous or delayed basis, subject to compliance with
applicable SEC rules, such one hundred twenty (120) day period shall be extended for up to ninety (90) days, if necessary, to keep the registration statement effective until all such
Registrable Securities are sold. 

6

 

          (b)     prepare
and file with the SEC such amendments and supplements to such registration statement, and the prospectus used in connection with such registration statement, as
may be necessary to comply with the Securities Act in order to enable the disposition of all securities covered by such registration statement; 

          (c)     furnish
to the selling Holders such numbers of copies of a prospectus, including a preliminary prospectus, as required by the Securities Act, and such other documents
as the Holders may reasonably request in order to facilitate their disposition of their Registrable Securities; 

          (d)     use
its commercially reasonable efforts to register and qualify the securities covered by such registration statement under such other securities or blue-sky laws of
such jurisdictions as shall be reasonably requested by the selling Holders; provided that the Company shall not be required to qualify to do business or to file a general consent to service of
process in any such states or jurisdictions, unless the
Company is already subject to service in such jurisdiction and except as may be required by the Securities Act; 

          (e)     in
the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and customary form, with the
underwriter(s) of such offering; 

          (f)     use
its commercially reasonable efforts to cause all such Registrable Securities covered by such registration statement to be listed on a national securities exchange
or trading system and each securities exchange and trading system (if any) on which similar securities issued by the Company are then listed; 

          (g)     provide
a transfer agent and registrar for all Registrable Securities registered pursuant to this Agreement and provide a CUSIP number for all such Registrable
Securities, in each case not later than the effective date of such registration; 

          (h)     promptly
make available for inspection by the selling Holders, any managing underwriter(s) participating in any disposition pursuant to such registration statement, and
any attorney or accountant or other agent retained by any such underwriter or selected by the selling Holders, all financial and other records, pertinent corporate documents, and properties of the
Company, and cause the Company's officers, directors, employees, and independent accountants to supply all information reasonably requested by any such seller, underwriter, attorney, accountant, or
agent, in each case, as necessary or advisable to verify the accuracy of the information in such registration statement and to conduct appropriate due diligence in connection therewith; 

          (i)      notify
each selling Holder, promptly after the Company receives notice thereof, of the time when such registration statement has been declared effective or a supplement
to any prospectus forming a part of such registration statement has been filed; and 

          (j)      after
such registration statement becomes effective, notify each selling Holder of any request by the SEC that the Company amend or supplement such registration
statement or prospectus. 

          In
addition, the Company shall ensure that, at all times after any registration statement covering a public offering of securities of the Company under the Securities Act shall have
become effective, its insider trading policy shall provide that the Company's directors may implement a trading program under Rule 10b5-1 of the Exchange Act. 

 
 
           2.5    Furnish Information.     It shall be a condition precedent to the obligations of the Company to
 take any action pursuant to this  Section 2 with respect to the Registrable Securities of any selling Holder that such Holder shall furnish to the Company such information
regarding itself, the Registrable Securities held by it, and the intended method of disposition of such securities as is reasonably required to effect the registration of such Holder's Registrable
Securities. 

7

 

 

 
 
           2.6    Expenses of Registration.     All expenses (other than Selling Expenses) incurred in connection
 with registrations, filings, or qualifications pursuant to  Section 2, including all registration, filing, and qualification fees; printers' and accounting fees; fees and disbursements of counsel
 for the
Company; and the reasonable fees and disbursements of one counsel for the selling Holders ("Selling Holder Counsel"), shall be borne and paid by the
Company; provided, however, that the Company shall not be required to pay for any expenses of any
registration proceeding begun pursuant to Section 2.1 if the registration request is subsequently withdrawn at the request of the Holders of a
majority of the Registrable Securities to be registered (in which case all selling Holders shall bear such expenses pro rata based upon the number of Registrable Securities that were to be included in
the withdrawn registration), unless the Requisite Holders agree to forfeit their right to one registration pursuant to Sections 2.1(a) or  2.1(b), as
the case may be; provided further that if, at the time of such withdrawal, the Holders shall
have learned of a material adverse change in the condition, business, or prospects of the Company from that known to the Holders at the time of their request and have withdrawn the request with
reasonable promptness after learning of such information then the Holders shall not be required to pay any of such expenses and shall not forfeit their right to one registration pursuant to  Sections 2.1(a) or 2.1(b). All Selling Expenses relating to Registrable Securities registered
pursuant to this Section 2 shall be borne and paid by the Holders pro rata on the basis of the number of Registrable Securities registered on
their behalf. 

 
 
          2.7    Delay of Registration.     No Holder shall have any right to obtain or seek an injunction
restraining or otherwise delaying any registration pursuant to this Agreement as the result of any
controversy that might arise with respect to the interpretation or implementation of this Section 2. 

 
 
          2.8    Indemnification.     If any Registrable Securities are included in a registration statement
under this Section 2: 

          (a)     To
the extent permitted by law, the Company will indemnify and hold harmless each selling Holder, and the partners, members, officers, directors, and stockholders of
each such Holder; legal counsel and
accountants for each such Holder; any underwriter (as defined in the Securities Act) for each such Holder; and each Person, if any, who controls such Holder or underwriter within the meaning of the
Securities Act or the Exchange Act, against any Damages, and the Company will pay to each such Holder, underwriter, controlling Person, or other aforementioned Person any legal or other expenses
reasonably incurred thereby in connection with investigating or defending any claim or proceeding from which Damages may result, as such expenses are incurred;  provided, however, that the indemnity agreement contained in this  Section 2.8(a) shall not apply to amounts paid in settlement of any such claim or proceeding if such
settlement is effected without the consent
of the Company, which consent shall not be unreasonably withheld, nor shall the Company be liable for any Damages to the extent that they arise out of or are based upon actions or omissions made in
reliance upon and in conformity with written information furnished by or on behalf of any such Holder, underwriter, controlling Person, or other aforementioned Person expressly for use in connection
with such registration. 

          (b)     To
the extent permitted by law, each selling Holder, severally and not jointly, will indemnify and hold harmless the Company, and each of its directors, each of its
officers who has signed the registration statement, each Person (if any), who controls the Company within the meaning of the Securities Act, legal counsel and accountants for the Company, any
underwriter (as defined in the Securities Act), any other Holder selling securities in such registration statement, and any controlling Person of any such underwriter or other Holder, against any
Damages, in each case only to the extent that such Damages arise out of or are based upon actions or omissions made in reliance upon and in conformity with written information furnished by or on
behalf of such selling Holder expressly for use in connection with such registration; and each such selling Holder will pay to the Company and each other 

8

 

aforementioned
Person any legal or other expenses reasonably incurred thereby in connection with investigating or defending any claim or proceeding from which Damages may result, as such expenses are
incurred; provided, however, that the indemnity agreement contained in this  Section 2.8(b) shall not
apply to amounts paid in settlement of any such claim or proceeding if such settlement is effected without the consent
of the Holder, which consent shall not be unreasonably withheld; and provided further that in no event shall the aggregate amounts payable by any Holder
by way of indemnity or contribution under Sections 2.8(b) and 2.8(d) exceed the proceeds from the
offering received by such Holder (net of any Selling Expenses paid by such Holder), except in the case of fraud or willful misconduct by such Holder. 

          (c)     Promptly
after receipt by an indemnified party under this Section 2.8 of notice of the commencement of any action
(including any governmental action) for which a party may be entitled to indemnification hereunder, such indemnified party will, if a claim in respect thereof is to be made against any indemnifying
party under this Section 2.8, give the indemnifying party notice of the commencement thereof. The indemnifying party shall have the right to
participate in such action and, to the extent the indemnifying
party so desires, participate jointly with any other indemnifying party to which notice has been given, and to assume the defense thereof with counsel mutually satisfactory to the parties;  provided,
however, that an indemnified party (together with all other indemnified parties that may be
represented without conflict by one counsel) shall have the right to retain one separate counsel, with the fees and expenses to be paid by the indemnifying party, if representation of such indemnified
party by the counsel retained by the indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any other party represented by such
counsel in such action. The failure to give notice to the indemnifying party within a reasonable time of the commencement of any such action shall relieve such indemnifying party of any liability to
the indemnified party under this Section 2.8, to the extent that such failure materially prejudices the indemnifying party's ability to defend
such action. The failure to give notice to the indemnifying party will not relieve it of any liability that it may have to any indemnified party otherwise than under this  Section 2.8. 

          (d)     To
provide for just and equitable contribution to joint liability under the Securities Act in any case in which either: (i) any party otherwise entitled to
indemnification hereunder makes a claim for indemnification pursuant to this Section 2.8 but it is judicially determined (by the entry of a final
judgment or decree by a court of competent jurisdiction and the expiration of time to appeal or the denial of the last right of appeal) that such indemnification may not be enforced in such case,
notwithstanding the fact that this Section 2.8 provides for indemnification in such case, or (ii) contribution under the Securities Act
may be required on the part of any party hereto for which indemnification is provided under this Section 2.8, then, and in each such case, such
parties will contribute to the aggregate losses, claims, damages, liabilities, or expenses to which they may be subject (after contribution from others) in such proportion as is appropriate to reflect
the relative fault of each of the indemnifying party and the indemnified party in connection with the statements, omissions, or other actions that resulted in such loss, claim, damage, liability, or
expense, as well as to reflect any other relevant equitable considerations. The relative fault of the indemnifying party and of the indemnified party shall be determined by reference to, among other
things, whether the untrue or allegedly untrue statement of a material fact, or the omission or alleged omission of a material fact, relates to information supplied by the indemnifying party or by the
indemnified party and the parties' relative intent, knowledge, access to information, and opportunity to correct or prevent such statement or omission;  provided, however, that, in any such case (x) no Holder will be required to contribute any amount
in excess of the public offering price 

9

 

of
all such Registrable Securities offered and sold by such Holder pursuant to such registration statement, and (y) no Person guilty of fraudulent misrepresentation (within the meaning of
Section 11(f) of the Securities Act) will be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation; and provided
further that in no event shall a Holder's liability pursuant to this Section 2.8(d), when combined with the amounts paid
or payable by such Holder pursuant to Section 2.8(b), exceed the proceeds from the offering received by such Holder (net of any Selling Expenses
paid by such Holder), except in the case of willful misconduct or fraud by such Holder. 

          (e)     Notwithstanding
the foregoing, to the extent that the provisions on indemnification and contribution contained in the underwriting agreement entered into in connection
with the IPO are in conflict with the foregoing provisions, the provisions in the underwriting agreement shall control. 

          (f)     Unless
otherwise superseded by an underwriting agreement entered into in connection with the underwritten public offering, the obligations of the Company and Holders
under this Section 2.8 shall survive the completion of any offering of Registrable Securities in a registration under this  Section 2, and
otherwise shall survive the termination of this Agreement. 

 
 
           2.9    Reports Under Exchange Act.     With a view to making available to the Holders the benefits of
 SEC Rule 144 and any other rule or regulation of the SEC that may at any time permit a
Holder to sell securities of the Company to the public without registration or pursuant to a registration on Form S-3, the Company shall: 

          (a)     make
and keep available adequate current public information, as those terms are understood and defined in SEC Rule 144, at all times after the effective date of
the registration statement filed by the Company for the IPO; 

          (b)     use
commercially reasonable efforts to file with the SEC in a timely manner all reports and other documents required of the Company under the Securities Act and the
Exchange Act (at any time after the Company has become subject to such reporting requirements); and 

          (c)     furnish
to any Holder, so long as the Holder owns any Registrable Securities, forthwith upon request (i) to the extent accurate, a written statement by the
Company that it has complied with the reporting requirements of SEC Rule 144 (at any time after ninety (90) days after the effective date of the registration statement filed by the
Company for the IPO), the Securities Act, and the Exchange Act (at any time after the Company has become subject to such reporting requirements), or that it qualifies as a registrant whose securities
may be resold pursuant to Form S-3 (at any time after the Company so qualifies); (ii) a copy of the most recent annual or quarterly report of the Company and such other reports and
documents so filed by the Company; and (iii) such other information as may be reasonably requested in availing any Holder of any rule or regulation of the SEC that permits the selling of any
such securities without registration (at any time after the Company has become subject to the reporting requirements under the Exchange Act) or pursuant to Form S-3 (at any time after the
Company so qualifies to use such form). 

 
 
           2.10    Limitations on Subsequent Registration Rights.     From and after the date of this Agreement,
 the Company shall not, without the prior written consent of the Requisite Holders, enter into any agreement with any
holder or prospective holder of any securities of the Company that would allow such holder or prospective holder to (i) include such securities in any registration unless, under the terms of
such agreement, such holder or prospective holder may include such securities in any such registration only to the extent that the inclusion of such securities will not reduce the number of the
Registrable Securities of the Holders that are included; or (ii) initiate a demand for 

10

 

registration
of any securities held by such holder or prospective holder; provided that this limitation shall not apply to any additional Investor who
becomes a party to this Agreement in accordance with Section 6.9. 

 
 
           2.11    "Market Stand-off" Agreement.     Each Holder hereby agrees that it will not, without the
 prior written consent of the managing underwriter, during the period commencing on the date of the final
prospectus relating to the registration by the Company of shares of its Common Stock or any other equity securities under the Securities Act on a registration statement on Form S-1, and ending
on the date specified by the Company and the managing underwriter (such period not to exceed one hundred eighty (180) days, or such other period as may be requested by the Company or an
underwriter to accommodate regulatory restrictions on (1) the publication or other distribution of research reports, and (2) analyst recommendations and opinions, including, but not
limited to, the restrictions contained in FINRA Rule 2711(f)(4) or NYSE Rule 472(f)(4), or any successor provisions or amendments thereto), (i) lend; offer; pledge; sell; contract
to sell; sell any option or contract to purchase; purchase any option or contract to sell; grant any option, right, or warrant to purchase; or otherwise transfer or dispose of, directly or indirectly,
any shares of Common Stock or any securities convertible into or exercisable or exchangeable (directly or indirectly) for Common Stock held immediately before the effective date of the registration
statement for such offering or (ii) enter into any swap or other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of such securities,
whether any such transaction described in clause (i) or (ii) above is to be settled by delivery of Common Stock or other securities, in cash, or otherwise. The foregoing provisions of
this Section 2.11 shall apply only to the IPO, shall not apply to the sale of any shares to an underwriter pursuant to an underwriting agreement,
or the transfer of any shares to any trust for the direct or indirect benefit of the Holder or the immediate family of the Holder, provided that the
trustee of the trust agrees to be bound in writing by the restrictions set forth herein, and provided further that any such transfer shall not involve a
disposition for value, and shall be applicable to the Holders only if all officers and directors are subject to the same restrictions and the Company uses commercially reasonable efforts to obtain a
similar agreement from all stockholders individually owning more than one percent (1%) of the Company's outstanding Common Stock (after giving effect to conversion into Common Stock of all outstanding
Preferred Stock). The underwriters in connection with such registration are intended third-party beneficiaries of this Section 2.11 and shall
have the right, power and authority to enforce the provisions hereof as though they were a party hereto. Each Holder further agrees to execute such agreements as may be reasonably requested by the
underwriters in connection with such registration that are consistent with this Section 2.11 or that are necessary to give further effect
thereto. Any discretionary waiver or termination of the restrictions of any or all of such agreements by the Company or the underwriters shall apply pro rata to all Holders subject to such agreements,
based on the number of shares subject to such agreements. 

 
 
           2.12    Restrictions on Transfer.     

          (a)     The
Preferred Stock and the Registrable Securities shall not be sold, pledged, or otherwise transferred, and the Company shall not recognize and shall issue
stop-transfer instructions to its transfer agent with respect to any such sale, pledge, or transfer, except upon the conditions specified in this Agreement, which conditions are intended to ensure
compliance with the provisions of the Securities Act. A transferring Holder will cause any proposed purchaser, pledgee, or transferee of the Preferred Stock and the Registrable Securities held by such
Holder to agree to take and hold such securities subject to the provisions and upon the conditions specified in this Agreement. 

          (b)     Each
certificate representing (i) the Preferred Stock, (ii) the Registrable Securities, and (iii) any other securities issued in respect of the
securities referenced in clauses (i) and (ii), upon any stock split, stock dividend, recapitalization, merger, consolidation, or similar 

11

 

event,
shall (unless otherwise permitted by the provisions of Section 2.12(c)) be endorsed with a legend substantially in the following form: 

THE
SECURITIES REPRESENTED HEREBY HAVE BEEN ACQUIRED FOR INVESTMENT AND HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933. SUCH SHARES MAY NOT BE SOLD, PLEDGED, OR TRANSFERRED IN THE
ABSENCE OF SUCH REGISTRATION OR A VALID EXEMPTION FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS OF SAID ACT. 

THE
SECURITIES REPRESENTED HEREBY MAY BE TRANSFERRED ONLY IN ACCORDANCE WITH THE TERMS OF AN AGREEMENT BETWEEN THE COMPANY AND THE STOCKHOLDER, A COPY OF WHICH IS ON FILE WITH THE SECRETARY OF THE
COMPANY. 

          The
Holders consent to the Company making a notation in its records and giving instructions to any transfer agent of the Restricted Securities in order to implement the restrictions on
transfer set forth in this Section 2.12. 

          (c)     The
holder of each certificate representing Restricted Securities, by acceptance of ownership thereof, agrees to comply in all respects with the provisions of this  Section 2. Before any proposed sale,
pledge, or transfer of any Restricted Securities, unless there is in effect a registration statement under
the Securities Act covering the proposed transaction, the Holder thereof shall give notice to the Company of such Holder's intention to effect such sale, pledge, or transfer. Each such notice shall
describe the manner and circumstances of the proposed sale, pledge, or transfer in sufficient detail and, if reasonably requested by the Company, shall be accompanied at such Holder's expense by
either (i) a written opinion of legal counsel who shall, and whose legal opinion shall, be reasonably satisfactory to the Company, addressed to the Company, to the effect that the proposed
transaction may be effected without registration under the Securities Act; (ii) a "no action" letter from the SEC to the effect that the proposed sale, pledge, or transfer of such Restricted
Securities without registration will not result in a recommendation by the staff of the SEC that action be taken with respect thereto; or (iii) any other evidence reasonably satisfactory to
counsel to the Company to the effect that the proposed sale, pledge, or transfer of the
Restricted Securities may be effected without registration under the Securities Act, whereupon the Holder of such Restricted Securities shall be entitled to sell, pledge, or transfer such Restricted
Securities in accordance with the terms of the notice given by the Holder to the Company. The Company will not require such a legal opinion or "no action" letter (x) in any transaction in
compliance with SEC Rule 144; or (y) in any transaction in which such Holder distributes Restricted Securities to an Affiliate of such Holder for no consideration;  provided that each
transferee agrees in writing to be subject to the terms of this Section 2.12.
Each certificate evidencing the Restricted Securities transferred as above provided shall bear, except if such transfer is made pursuant to SEC Rule 144, the appropriate restrictive legend set
forth in Section 2.12(b), except that such certificate shall not bear such restrictive legend if, in the opinion of counsel for such Holder and
the Company, such legend is not required in order to establish compliance with any provisions of the Securities Act. 

 
 
           2.13    Termination of Registration Rights.     The right of any Holder to request registration or
 inclusion of Registrable Securities in any registration pursuant to  Sections 2.1 or 2.2 shall terminate upon the earliest to occur of:
 

          (a)     the
closing of a Deemed Liquidation Event, as such term is defined in the Company's Certificate of Incorporation; 

12

 

          (b)     such
time as (i) such Holder holds less than one percent (1%) of all Registrable Securities then outstanding and (ii) Rule 144 or another similar
exemption under the Securities Act is available for the sale of all of such Holder's shares without limitation during a three-month period without registration; and 

          (c)     the
later of (i) the fifth (5th) anniversary of the Qualified IPO (as defined in the Company's Certificate of Incorporation) and
(ii) August 23, 2020. 

 
 
          3.    Information and Observer Rights.     

 
 
           3.1    Delivery of Financial Statements.     The Company shall deliver to each Major Investor:
 

          (a)     as
soon as practicable, but in any event within one hundred twenty (120) days after the end of each fiscal year of the Company (i) a balance sheet as of
the end of such year, (ii) statements of income and of cash flows for such year, and a comparison between (x) the actual amounts as of and for such fiscal year and (y) the
comparable amounts for the prior year and as included in the Budget (as defined in Section 3.1(e)) for such year, with an explanation of any
material differences between such amounts and a schedule as to the sources and applications of funds for such year, and (iii) a statement of stockholders' equity as of the end of such year, all
such financial statements audited and certified by independent public accountants of nationally or regionally recognized standing selected by the Company; 

          (b)     as
soon as practicable, but in any event within forty-five (45) days after the end of each of the first three (3) quarters of each fiscal year of the
Company, unaudited statements of income and cash flows for such fiscal quarter, and an unaudited balance sheet and a statement of stockholders' equity as of the end of such fiscal quarter, all
prepared in accordance with GAAP (except that such financial statements may (i) be subject to normal year-end audit adjustments; and (ii) not contain all notes thereto that may be
required in accordance with GAAP); 

          (c)     as
soon as practicable, but in any event within forty-five (45) days after the end of each of the first three (3) quarters of each fiscal year of the
Company, a statement showing the number of shares of each class and series of capital stock and securities convertible into or exercisable for shares of capital stock outstanding at the end of the
period, the Common Stock issuable upon conversion or exercise of any outstanding securities convertible or exercisable for Common Stock and the exchange ratio or exercise price applicable thereto, and
the number of shares of issued stock options and stock options not yet issued but reserved for issuance, if any, all in sufficient detail as to permit the Major Investors to calculate their respective
percentage equity ownership in the Company, and certified by the chief financial officer or chief executive officer of the Company as being true, complete, and correct; 

          (d)     as
soon as practicable, but in any event within thirty (30) days of the end of each month, an unaudited income statement and statement of cash flows for such
month, and an unaudited balance sheet and statement of stockholders' equity as of the end of such month, all prepared in accordance with GAAP (except that such financial statements may (i) be
subject to normal year-end audit adjustments and (ii) not contain all notes thereto that may be required in accordance with GAAP); 

          (e)     as
soon as practicable, but in any event thirty (30) days before the end of each fiscal year, a budget and business plan for the next fiscal year (collectively,
the "Budget"), approved by the Board of Directors and prepared on a monthly basis, including balance sheets, income statements, and statements of cash
flow for such months and, promptly after prepared, any other budgets or revised budgets prepared by the Company; 

13

 

 

          (f)     with
respect to the financial statements called for in Section 3.1(a),  Section 3.1(b) and Section 3.1(d), an instrument executed by the chief financial officer
and chief executive officer of the Company certifying that such financial statements were prepared in accordance with GAAP consistently applied with prior practice for earlier periods (except as
otherwise set forth in Section 3.1(b) and Section 3.1(d)) and fairly present the financial
condition of the Company and its results of operation for the periods specified therein; and 

          (g)     such
other information relating to the financial condition, business, prospects, or corporate affairs of the Company as any Major Investor may from time to time
reasonably request; provided, however, that the Company shall not be obligated under this  Section 3.1
to provide information (i) that the Company reasonably determines in good faith to be a trade secret or confidential
information (unless covered by an enforceable confidentiality agreement, in a form acceptable to the Company); or (ii) the disclosure of which, in the opinion of counsel, would adversely affect
the attorney-client privilege between the Company and its counsel. 

          If,
for any period, the Company has any subsidiary whose accounts are consolidated with those of the Company, then in respect of such period the financial statements delivered pursuant
to the foregoing sections shall be the consolidated and consolidating financial statements of the Company and all such consolidated subsidiaries. 

          Notwithstanding
anything else in this Section 3.1 to the contrary, the Company may cease providing the information set forth in
this Section 3.1 during the period starting with the date thirty (30) days before the Company's good-faith estimate of the date of filing
of a registration statement if it reasonably concludes it must do so to comply with the SEC rules applicable to such registration statement and related offering;  provided that the Company's covenants
under this Section 3.1 shall be reinstated at such time as
the Company is no longer actively employing its commercially reasonable efforts to cause such registration statement to become effective. 

 
 
           3.2    Inspection.     The Company shall permit each Major Investor, at such Major Investor's expense,
 to visit and inspect the Company's properties; examine its books of account and
records; and discuss the Company's affairs, finances, and accounts with its officers, during normal business hours of the Company as may be reasonably requested by the Major Investor;  provided,
however, that the Company shall not be obligated pursuant to this  Section 3.2 to provide access to any information that it reasonably and in good
faith considers to be a trade secret or confidential information
(unless covered by an enforceable confidentiality agreement, in form acceptable to the Company) or the disclosure of which would adversely affect the attorney-client privilege between the Company and
its counsel. 

 
 
           3.3    Observer Rights.     As long as MPM Capital owns not less than 33% of the shares of the
 Preferred Stock acquired by MPM Capital (including its Affiliates) pursuant to the Purchase
Agreement, the Company shall invite a representative of MPM Capital to attend all meetings of its Board of Directors in a nonvoting observer capacity and, in this respect, shall give such
representative copies of all notices, minutes, consents, and other materials that it provides to its directors at the same time and in the same manner as provided to such directors; provided, however,
that such representative shall agree to hold in confidence and trust and to act in a fiduciary manner with respect to all information so provided; and provided further, that the Company reserves the
right to withhold any information and to exclude such representative from any meeting or portion thereof if access to such information or attendance at such meeting could materially adversely affect
the attorney-client privilege between the Company and its counsel or result in an actual conflict of interest, or if such Investor or its representative is a direct competitor of the Company. 

 
 
           3.4    Termination of Information Rights.     The covenants set forth in Section 3.1, Section 3.2
and Section 3.3 shall terminate and be of no further force or effect (i) immediately before the consummation of the Qualified IPO,
(ii) when the Company first becomes subject to the periodic 

14

 

reporting
requirements of Section 12(g) or 15(d) of the Exchange Act, or (iii) upon a Deemed Liquidation Event, as such term is defined in the Company's Certificate of Incorporation,
whichever event occurs first. 

 
 
          3.5    Confidentiality.     Each Investor agrees that such Investor will keep confidential and will not
disclose, divulge, or use for any purpose (other than to monitor its investment in the
Company) any confidential information obtained from the Company pursuant to the terms of this Agreement (including notice of the Company's intention to file a registration statement), unless
such confidential information (a) is known or becomes known to the public in general (other than as a result of a breach of this  Section 3.5 by such Investor), (b) is or has been
independently developed or conceived by the Investor without use of the Company's
confidential information, or (c) is or has been made known or disclosed to the Investor by a third party without a breach of any obligation of confidentiality such third party may have to the
Company; provided, however, that an Investor may disclose confidential information (i) to its
attorneys, accountants, consultants, and other professionals to the extent necessary to obtain their services in connection with monitoring its investment in the Company; (ii) to any
prospective purchaser of any Registrable Securities from such Investor, if such prospective purchaser agrees to be bound by the provisions of this  Section 3.5; (iii) to any existing or
prospective Affiliate, partner, member, stockholder, or wholly owned subsidiary of such Investor in
the ordinary course of business, provided that such Investor informs such Person that such information is confidential and directs such Person to
maintain the confidentiality of such information; or (iv) as may otherwise be required by law, provided that the Investor promptly notifies the
Company of such disclosure and takes reasonable steps to minimize the extent of any such required disclosure. 

          4.    Rights to Future Stock Issuances.    

 
 
          4.1    Right of First Offer.     Subject to the terms and conditions of this Section 4.1 and applicable securities laws, if the Company
proposes to offer or sell any New Securities, the Company shall first offer such New Securities to the Major Investors. A Major Investor shall be entitled to apportion the right of first offer hereby
granted to it. in such proportions as it deems appropriate, among (i) itself, (ii) its Affiliates and (iii) its beneficial interest holders, such as limited partners, members or
any other Person having "beneficial ownership," as such term is defined in Rule 13d-3 promulgated under the Exchange Act, of such Major Investor ("Investor Beneficial
Owners"); provided that each such Affiliate or Investor Beneficial Owner agrees to enter into this Agreement and each of the
Voting Agreement and Second Amended and Restated Right of First Refusal and Co-Sale Agreement of even date herewith among the Company, the Investors and the other parties named therein, as an
"Investor" under each such agreement. 

          (a)     The
Company shall give notice (the "Offer Notice") to each Major Investor, stating (i) its bona fide intention to
offer such New Securities, (ii) the number of such New Securities to be offered, and (iii) the price and terms, if any, upon which it proposes to offer such New Securities. 

          (b)     By
notification to the Company within twenty (20) days after the Offer Notice is given, each Major Investor may elect to purchase or otherwise acquire, at the
price and on the terms specified in the Offer Notice, up to that portion of such New Securities which equals the proportion that the Common Stock then held by such Major Investor (including all shares
of Common Stock then issuable (directly or indirectly) upon conversion and/or exercise, as applicable, of the Preferred Stock and any other Derivative Securities then held by such Major Investor)
bears to the total Common Stock of the Company then held by all the Major Investors (including all shares of Common Stock issuable (directly or indirectly)
upon conversion and/or exercise, as applicable, of the Preferred Stock and any other Derivative Securities then held by the Major Investors). At the expiration of such twenty (20) day period,
the Company shall promptly notify each Major Investor that elects to purchase or 

15

 

acquire
all the shares available to it (each, a "Fully Exercising Investor") of any other Major Investor's failure to do likewise. During the ten
(10) day period commencing after the Company has given such notice, each Fully Exercising Investor may, by giving notice to the Company, elect to purchase or acquire, in addition to the number
of shares specified above, up to that portion of the New Securities for which Major Investors were entitled to subscribe but that were not subscribed for by the Major Investors which is equal to the
proportion that the Common Stock issued and held, or issuable (directly or indirectly) upon conversion and/or exercise, as applicable, of Preferred Stock and any other Derivative Securities then held,
by such Fully Exercising Investor bears to the Common Stock issued and held, or issuable (directly or indirectly) upon conversion and/or exercise, as applicable, of the Preferred Stock and any other
Derivative Securities then held, by all Fully Exercising Investors who wish to purchase such unsubscribed shares. The closing of any sale pursuant to this  Section 4.1(b) shall occur within the
later of ninety (90) days of the date that the Offer Notice is given and the date of initial sale of
New Securities pursuant to Section 4.1(c). 

          (c)     If
all New Securities referred to in the Offer Notice are not elected to be purchased or acquired as provided in  Section 4.1(b), the Company may, during the ninety (90) day period following the
expiration of the periods provided in  Section 4.1(b), offer and sell the remaining unsubscribed portion of such New Securities to any Person or Persons at a price not less than, and
upon terms no more favorable to the offeree than, those specified in the Offer Notice. If the Company does not enter into an agreement for the sale of the New Securities within such period, or if such
agreement is not consummated within thirty (30) days of the execution thereof, the right provided hereunder shall be deemed to be revived and such New Securities shall not be offered unless
first reoffered to the Major Investors in accordance with this Section 4.1. 

          (d)     The
right of first offer in this Section 4.1 shall not be applicable to (i) Exempted Securities (as
defined in the Company's Certificate of Incorporation); (ii) shares of Common Stock issued in the IPO; and (iii) the issuance of shares of Series B Preferred Stock to Hercules or
Additional Purchasers pursuant to Section 1.2 of the Purchase Agreement. 

 
 
           4.2    Termination.     The covenants set forth in Section 4.1 shall terminate and be of no further force or effect
(i) immediately before the consummation of the Qualified IPO, or (ii) upon a Deemed Liquidation Event, as such term is defined in the Company's Certificate of Incorporation, whichever
event occurs first. 

          5.    Additional Covenants.    

 
 
           5.1    Insurance.     The Company shall use its commercially reasonable efforts to obtain, within
 thirty (30) days of the date hereof, from financially sound and reputable
insurers, Directors and Officers liability insurance coverage in an amount of at least $3 million per occurrence, with such terms, conditions and policy limits satisfactory to the Board of
Directors (including at least three Series B Directors), and will use commercially reasonable efforts to cause such insurance policies to be maintained until such time as the Board of Directors
(including at least three Series B Directors) determines that such insurance should be discontinued. Such policy shall not be cancelable by the Company without prior approval by the Board of
Directors (including at least three Series B Directors). The Company shall use its commercially reasonable efforts prior to an IPO to increase its Directors and Officers liability insurance to
at least $20 million per occurrence, including coverage of claims under the Securities Act and the Exchange Act. Notwithstanding any other provision of this Section 5.1 to the contrary,
for so long as a Series B Director is serving on the Board of Directors, the Company shall not cease to maintain a Directors and Officers liability insurance policy in an amount of at least
(x) $3 million per occurrence prior to an IPO and (y) $20 million per occurrence in connection with and after and IPO, unless approved by at least three Series B
Directors (or a majority of the Series B Directors if less than five Series B Directors 

16

 

is
then serving on the Board of Directors) and the Company shall annually, within one hundred twenty (120) days after the end of each fiscal year of the Company, deliver to NEA and each
Series B Director a certification that such a Directors and Officers liability insurance policy remains in effect. 

 
 
           5.2    Employee Agreements.     The Company will cause each person now or hereafter employed by it or
 by any subsidiary (or engaged by the Company or any subsidiary as a consultant/independent
contractor) with access to confidential information and/or trade secrets to enter into a nondisclosure and proprietary rights assignment agreement, in the form attached hereto as  Exhibit A. In
addition, the Company shall not amend, modify, terminate, waive, or otherwise alter, in whole or in part, any of the
above-referenced agreements or any restricted stock agreement between the Company and any employee, without the consent of at least three Series B Directors. 

 
 
           5.3    Employee Stock.     Unless otherwise approved by the Board of Directors, including at least
 three Series B Directors, all future employees and consultants of the Company who
purchase, receive options to purchase, or receive awards of shares of the Company's capital stock after the date hereof shall be required to execute restricted stock or option agreements, as
applicable, providing for (i) vesting of shares over a four (4) year period, with the first twenty-five percent (25%) of such shares vesting following twelve (12) months of
continued employment or service, and the remaining shares vesting in equal monthly installments over the following thirty-six (36) months, and (ii) a market stand-off provision
substantially similar to that in Section 2.11. In addition, unless otherwise approved by the Board of Directors, including at least three
Series B Directors, the Company shall retain a "right of first refusal" on employee transfers until the Company's IPO and shall have the right to repurchase unvested shares at cost upon
termination of employment of a holder of restricted stock. 

 
 
           5.4    Qualified Small Business Stock.     The Company shall use commercially reasonable efforts to
 cause the shares of Series B Preferred Stock issued pursuant to the Purchase Agreement, as well as
any shares into which such shares are converted, within the meaning of Section 1202(f) of the Internal Revenue Code (the "Code"), to constitute
"qualified small business stock" as defined in Section 1202(c) of the Code. The Company shall submit to its stockholders (including the Investors) and to the Internal Revenue Service any
reports that may be required under Section 1202(d)(1)(C) of the Code and the regulations promulgated thereunder. In addition, within twenty (20) business days after any Investor's
written request therefor, the Company shall, at its option, either (i) deliver to such Investor a written statement indicating whether (and what portion of) such Investor's interest in the
Company constitutes "qualified small business stock" as defined in Section 1202(c) of the Code or (ii) deliver to such Investor such factual information in the Company's possession as is
reasonably necessary to enable such Investor to determine whether (and what portion of) such Investor's interest in the Company constitutes "qualified small business stock" as defined in
Section 1202(c) of the Code. The Company's obligation to furnish a written statement pursuant to this Section 5.4 shall continue notwithstanding the fact that a class of the Company's
stock may be traded on an established securities market. 

 
 
           5.5    Successor Indemnification.     If the Company or any of its successors or assignees
 consolidates with or merges into any other Person and is not the continuing or surviving corporation or
entity of such consolidation or merger, then to the extent necessary, proper provision shall be made so that the successors and assignees of the Company assume the obligations of the Company with
respect to indemnification of members of the Board of Directors as in effect immediately before such transaction, whether such obligations are contained in the Company's Bylaws, its Certificate of
Incorporation, or elsewhere, as the case may be. 

 
 
           5.6    Expenses of Counsel.     In the event of a transaction which is a Sale of the Company (as
 defined in the Voting Agreement of even date herewith among the Investors and the Company), 

17

 

the
reasonable fees and disbursements of one counsel for the Major Investors ("Investor Counsel"), in their capacities as stockholders, shall be borne
and paid by the Company. At the outset of considering a transaction which, if consummated would constitute a Sale of the Company, the Company shall obtain the ability to share with the Investor
Counsel (and such counsel's clients) and shall share the confidential information (including, without limitation, the initial and all subsequent drafts of memoranda of understanding, letters of intent
and other transaction documents and related noncompete, employment, consulting and other compensation agreements and plans) pertaining to and memorializing any of the transactions which, individually
or when aggregated with others would constitute the Sale of the Company. The Company shall be obligated to share (and cause the Company's counsel and investment bankers to share) such materials when
distributed to the Company's executives and/or any one or more of the other parties to such transaction(s). In the event that Investor Counsel deems it appropriate, in its reasonable discretion, to
enter into a joint defense agreement or other arrangement to enhance the ability of the parties to protect their communications and other reviewed materials under the attorney client privilege, the
Company shall, and shall direct its counsel to, execute and deliver to Investor Counsel and its clients such an agreement in form and substance reasonably acceptable to Investor Counsel. In the event
that one or more of the other party or parties to such transactions require the clients of Investor Counsel to enter into a confidentiality agreement and/or joint defense agreement in order to receive
such information, then the Company shall share whatever information can be shared without entry into such agreement and shall, at the same time, in good faith work expeditiously to enable Investor
Counsel and its clients to negotiate and enter into the appropriate agreement(s) without undue burden to the clients of Investor Counsel. 

 
 
           5.7    Indemnification Matters.     The Company hereby acknowledges that one (1) or more of the
 directors nominated to serve on the Board of Directors by the Investors (each a
"Fund Director") may have certain rights to indemnification, advancement of expenses and/or insurance provided by one or more of the Investors and
certain of their affiliates (collectively, the "Fund Indemnitors"). The Company hereby agrees (a) that it is the indemnitor of first resort
(i.e., its obligations to any such Fund Director are primary and any obligation of the Fund Indemnitors to advance expenses or to provide
indemnification for the same expenses or liabilities incurred by such Fund Director are secondary), (b) that it shall be required to advance the full amount of expenses incurred by such Fund
Director and shall be liable for the full amount of all expenses, judgments, penalties, fines and amounts paid in settlement by or on behalf of any such Fund Director to the extent legally permitted
and as required by the Company's Certificate of Incorporation or Bylaws of the Company (or any agreement between the Company and such Fund Director), without regard to any rights such Fund Director
may have against the Fund Indemnitors, and, (c) that it irrevocably waives, relinquishes and releases the Fund Indemnitors from any and all claims against the Fund Indemnitors for contribution,
subrogation or any other recovery of any kind in respect thereof. The Company further agrees that no advancement or payment by the Fund Indemnitors on behalf of any such Fund Director with respect to
any claim for which such Fund Director has sought indemnification from the Company shall affect the foregoing and the Fund Indemnitors shall have a right of contribution and/or be subrogated to the
extent of such advancement or payment to all of the rights of recovery of such Fund Director against the Company. 

 
 
           5.8    Right to Conduct Activities.     The Company hereby agrees and acknowledges that each Major
 Investor (together with their respective affiliates) is a professional investment fund, and as such
invests in numerous portfolio companies, some of which may be deemed competitive with the Company's business (as currently conducted or as currently propose to be conducted). The Company hereby agrees
that, to the extent permitted under applicable law, each such Major Investor shall not be liable to the Company for any claim arising out of, or based upon, (i) the investment by such Major
Investor in any entity competitive with the Company, or (ii) actions taken by any partner, officer or other representative of such Major Investor to assist any such competitive company, whether
or not such action was taken as a member of the board of directors of such 

18

 

competitive
company or otherwise, and whether or not such action has a detrimental effect on the Company; provided, however, that the foregoing shall not relieve (x) any of the Investors from
liability associated with the unauthorized disclosure of the Company's confidential information obtained pursuant to this Agreement, or (y) any director or officer of the Company from any
liability associated with his or her fiduciary duties to the Company. 

 
 
           5.9    FCPA.     The Company represents that it shall not (and shall not permit any of its
 subsidiaries or affiliates or any of its or their respective directors, officers,
managers, employees, independent contractors, representatives or agents to) promise, authorize or make any payment to, or otherwise contribute any item of value to, directly or indirectly, to any
third party, including any Non-U.S. Official (as (as such term is defined in the U.S. Foreign Corrupt Practices Act of 1977, as amended (the "FCPA")),
in each case, in violation of the FCPA, the U.K. Bribery Act, or any other applicable anti-bribery or anti-corruption law. The Company further represents that it shall (and shall cause each of its
subsidiaries and affiliates to) cease all of its or their respective activities, as well as remediate any actions taken by the Company, its subsidiaries or affiliates, or any of their respective
directors, officers, managers, employees, independent contractors, representatives or agents in violation of the FCPA, the U.K. Bribery Act, or any other applicable anti-bribery or anti-corruption
law. The Company further represents that it shall (and shall cause each of its subsidiaries and affiliates to) maintain systems of internal controls (including, but not limited to, accounting systems,
purchasing systems and billing systems) to ensure compliance with the FCPA, the U.K. Bribery Act, or any other applicable anti-bribery or anti-corruption law. Upon request, the Company agrees to
provide responsive information and/or certifications concerning its compliance with applicable anti-corruption laws. The Company shall promptly notify each Major Investor if the Company becomes aware
of any Enforcement Action (as defined in the Purchase Agreement). The Company shall, and shall cause any direct or indirect subsidiary or entity controlled by it, whether now in existence or formed in
the future, to comply with the FCPA. The Company shall use its best efforts to cause any direct or indirect subsidiary, whether now in existence or formed in the future, to comply in all material
respects with all applicable laws. 

 
 
          5.10    FIRPTA.     The Company shall provide prompt notice to New Enterprise Associates 14, Limited
Partnership ("NEA 14") following any "determination date" (as defined in Treasury
Regulation Section 1.897-2(c)(1)) on which the Company becomes a United States real property holding corporation. In addition, upon a written request by NEA 14, the Company shall provide NEA 14
with a written statement informing NEA 14 whether NEA 14's interest in the Company constitutes a United States real property interest. The Company's determination shall comply with the requirements of
Treasury Regulation Section 1.897-2(h)(1) or any successor regulation, and the Company shall provide timely notice to the Internal Revenue Service, in accordance with and to the extent required
by Treasury Regulation Section 1.897-2(h)(2) or any successor regulation, that such statement has been made. The Company's written statement to NEA 14 shall be delivered to NEA 14 within
10 days of NEA 14's written request therefor. The Company's obligation to furnish such written statement shall continue notwithstanding the fact that a class of the Company's stock may be
regularly traded on an established securities market or the fact that there is no preferred stock then outstanding. 

 
 
           5.11    Termination of Covenants.     The covenants set forth in Sections 5.2, 5.3 and 5.9 shall
 terminate and be of no further force or effect (i) immediately before the consummation of
the Qualified IPO or (ii) upon a Deemed Liquidation Event, as such term is defined in the Company's Certificate of Incorporation, whichever event occurs first. 

          6.    Miscellaneous.    

 
 
           6.1    Successors and Assigns.     The rights under this Agreement may be assigned (but only with all
 related obligations) by a Holder to a transferee of Registrable Securities that (i) is
an Affiliate of a Holder; (ii) is a Holder's Immediate Family Member or trust for the benefit of an 

19

 

individual
Holder or one or more of such Holder's Immediate Family Members; or (iii) after such transfer, holds at least two percent (2%) of the shares of Registrable Securities then
outstanding; provided, however, that (x) the Company is, within a reasonable time after such
transfer, furnished with written notice of the name and address of such transferee and the Registrable Securities with respect to which such rights are being transferred; and (y) such
transferee agrees in a written instrument delivered to the Company to be bound by and subject to the terms and conditions of this Agreement, including the provisions of  Section 2.11. For the
purposes of determining the number of shares of Registrable Securities held by a transferee, the holdings of a transferee
(1) that is an Affiliate or stockholder of a Holder; (2) who is a Holder's Immediate Family Member; or (3) that is a trust for the benefit of an individual Holder or such Holder's
Immediate Family Member shall be aggregated together and with those of the transferring Holder; provided further that all transferees who would not
qualify individually for assignment of rights shall have a single attorney-in-fact for the purpose of exercising any rights, receiving notices, or taking any action under this Agreement. The terms and
conditions of this Agreement inure to the benefit of and are binding upon the respective successors and permitted assignees of the parties. Nothing in this Agreement, express or implied, is intended
to confer upon any party other than the parties hereto or their respective successors and permitted assignees any rights, remedies, obligations or liabilities under or by reason of this Agreement,
except as expressly provided herein. 

 
 
           6.2    Governing Law.     This Agreement shall be governed by, and construed in accordance with, the
 laws of the State of Delaware, without regard to conflict of law principles that would
result in the application of the laws of any other jurisdiction. 

 
 
           6.3    Counterparts.     This Agreement may be executed in two or more counterparts, each of which
 shall be deemed an original, but all of which together shall constitute one and the same
instrument. Counterparts may be delivered via facsimile, electronic mail (including pdf) or other transmission method and any counterpart so delivered shall be deemed to have been duly and validly
delivered and be valid and effective for all purposes. 

 
 
          6.4    Titles and Subtitles.     The titles and subtitles used in this Agreement are used for
convenience only and are not to be considered in construing or interpreting this Agreement. 

 
 
           6.5    Notices.     All notices and other communications given or made pursuant to this Agreement
 shall be in writing and shall be deemed effectively given upon the earlier of actual
receipt or (a) personal delivery to the party to be notified, (b) when sent, if sent by facsimile (with delivery confirmation) or email during normal business hours of the recipient, and
if not sent during normal business hours, then on the recipient's next business day, (c) five (5) days after having been sent by registered or certified mail, return receipt requested,
postage prepaid, or (d) one (1) business day after deposit with a nationally recognized overnight courier, freight prepaid, specifying next business day delivery, with written
verification of receipt. All communications shall be sent to the respective parties at their address as set forth on the signature page,  Schedule A or Schedule B hereof, as the case may be, or to such email address, facsimile
number or address as subsequently modified by written notice given in accordance with this Section 6.5. If notice is given to the Company, a
mandatory copy (which shall not constitute notice) shall also be sent to Cooley LLP, 1299 Pennsylvania Avenue NW, Washington DC, 20004-2400, Attention: Aaron Velli, Facsimile:
(202) 842-7899, Email: avelli@cooley.com and if notice is given to any Stockholder, a mandatory copy (which shall not constitute notice) shall also be sent to Proskauer Rose LLP, One
International Place, Boston, MA 02110, Attention: Ori Solomon, Facsimile: (617) 526-9899, Email: osolomon@proskauer.com. 

 
 
           6.6    Amendments and Waivers.     Any term of this Agreement may be amended and the observance of any
 term of this Agreement may be waived (either generally or in a particular instance, and either
retroactively or prospectively) only with the written consent of the Company and the Requisite Holders; provided that the Company may in its sole
discretion waive compliance 

20

 

with
Section 2.12(c) (and the Company's failure to object promptly in writing after notification of a proposed assignment allegedly in violation
of Section 2.12(c) shall be deemed to be a waiver); and provided further that any provision
hereof may be waived by any waiving party on such party's own behalf, without the consent of any other party. Notwithstanding the foregoing, this Agreement may not be amended or terminated and the
observance of any term hereof may not be waived with respect to any Investor without the written consent of such Investor, unless such amendment, termination, or waiver applies to all Investors in the
same fashion (it being agreed that a waiver of the provisions of Section 4 with respect to a particular transaction shall be deemed to apply to
all Investors in the same fashion if such waiver does so by its terms, notwithstanding the fact that certain Investors may nonetheless, by agreement with the Company, purchase securities in such
transaction). The Company shall give
prompt notice of any amendment or termination hereof or waiver hereunder to any party hereto that did not consent in writing to such amendment, termination, or waiver. Any amendment, termination, or
waiver effected in accordance with this Section 6.6 shall be binding on all parties hereto, regardless of whether any such party has consented
thereto. No waivers of or exceptions to any term, condition, or provision of this Agreement, in any one or more instances, shall be deemed to be or construed as a further or continuing waiver of any
such term, condition, or provision. 

 
 
          6.7    Severability.     In case any one or more of the provisions contained in this Agreement is for
any reason held to be invalid, illegal or unenforceable in any respect, such
invalidity, illegality, or unenforceability shall not affect any other provision of this Agreement, and such invalid, illegal, or unenforceable provision shall be reformed and construed so that it
will be valid, legal, and enforceable to the maximum extent permitted by law. 

 
 
           6.8    Aggregation of Stock.     All shares of Registrable Securities held or acquired by Affiliates
 shall be aggregated together for the purpose of determining the availability of any rights
under this Agreement and such Affiliated persons may apportion such rights as among themselves in any manner they deem appropriate. 

 
 
           6.9    Additional Investors.     Notwithstanding anything to the contrary contained herein, if the
 Company issues additional shares of the Company's Series B Preferred Stock after the date
hereof, any purchaser of such shares of Series B Preferred Stock may become a party to this Agreement by executing and delivering an additional counterpart signature page to this Agreement, and
thereafter shall be deemed an "Investor" for all purposes hereunder. No action or consent by the Investors shall be required for such joinder to this Agreement by such additional Investor, so long as
such additional Investor has agreed in writing to be bound by all of the obligations as an "Investor" hereunder. 

 
 
           6.10    Entire Agreement.     This Agreement (including any Schedules and Exhibits hereto) constitutes
 the full and entire understanding and agreement among the parties with respect to the
subject matter hereof, and any other written or oral agreement relating to the subject matter hereof existing between the parties is expressly canceled. Upon the effectiveness of this Agreement, the
Prior Agreement shall be deemed amended and restated and superseded and replaced in its entirety by this Agreement, and shall be of no further force or effect. 

 
 
           6.11    Dispute Resolution.     The parties (a) hereby irrevocably and unconditionally submit to
 the jurisdiction of the state courts of the State of Delaware and to the jurisdiction of
the United States District Court for the District of Delaware for the purpose of any suit, action or other proceeding arising out of or based upon this Agreement, (b) agree not to commence any
suit, action or other proceeding arising out of or based upon this Agreement except in the state courts of the State of Delaware or the United States District Court for the District of Delaware, and
(c) hereby waive, and agree not to assert, by way of motion, as a defense, or otherwise, in any such suit, action or proceeding, any claim that it is not subject personally to the jurisdiction
of the above-named courts, that its property is exempt or immune from attachment or execution, that the 

21

 

suit,
action or proceeding is brought in an inconvenient forum, that the venue of the suit, action or proceeding is improper or that this Agreement or the subject matter hereof may not be enforced in
or by such court. The prevailing party shall be entitled to reasonable attorney's fees, costs, and necessary disbursements in addition to any other relief to which such party may be entitled. Each of
the parties to this Agreement consents to personal jurisdiction for any equitable action sought in the U.S. District Court for the District of Delaware or any court of the State of Delaware having
subject matter jurisdiction. 

 
 
           6.12    Waiver of Jury Trial.     EACH PARTY HEREBY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM OR
 CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT, THE OTHER TRANSACTION DOCUMENTS,
THE SECURITIES OR THE SUBJECT MATTER HEREOF OR THEREOF. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL-ENCOMPASSING OF ANY AND ALL DISPUTES THAT MAY BE FILED IN ANY COURT AND THAT RELATE TO THE
SUBJECT MATTER OF THIS TRANSACTION, INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS, TORT CLAIMS (INCLUDING NEGLIGENCE), BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY CLAIMS. THIS
SECTION HAS BEEN FULLY DISCUSSED BY EACH OF THE PARTIES HERETO AND THESE PROVISIONS WILL NOT BE SUBJECT TO ANY EXCEPTIONS. EACH PARTY HERETO HEREBY FURTHER WARRANTS AND REPRESENTS THAT SUCH PARTY HAS
REVIEWED THIS WAIVER WITH ITS LEGAL COUNSEL, AND THAT SUCH PARTY KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL RIGHTS FOLLOWING CONSULTATION WITH LEGAL COUNSEL. 

 
 
           6.13    Delays or Omissions.     No delay or omission to exercise any right, power, or remedy accruing
 to any party under this Agreement, upon any breach or default of any other party under this
Agreement, shall impair any such right, power, or remedy of such nonbreaching or nondefaulting party, nor shall it be construed to be a waiver of or acquiescence to any such breach or default, or to
any similar breach or default thereafter occurring, nor shall any waiver of any single breach or default be deemed a waiver of any other breach or default theretofore or thereafter occurring. All
remedies, whether under this Agreement or by law or otherwise afforded to any party, shall be cumulative and not alternative. 

 
 
           6.14    Acknowledgment.     The Company acknowledges that the Investors are in the business of venture
 capital investing and therefore review the business plans and related proprietary
information of many enterprises, including enterprises which may have products or services which compete directly or indirectly with those of the Company. Nothing in this Agreement shall preclude or
in any way restrict the Investors from investing or participating in any particular enterprise whether or not such enterprise has products or services which compete with those of the Company. 

[Remainder
of Page Intentionally Left Blank] 

22

          IN
WITNESS WHEREOF, the parties have executed this Agreement as of the date first written above. 

 

					
	 	 	 COMPANY:
	

 	
 	
 CERECOR INC.
	

 	
 	
 By:	
 	
/s/ BLAKE PATERSON

 
	 	 	 	 	Name: Blake Paterson
	 	 	 	 	Title: Chief Executive Officer

 

   

   

  SIGNATURE PAGE TO INVESTORS' RIGHTS AGREEMENT

 

Signed by the following Investors:  

New
Enterprise Associates 14, L.P.

NEA Ventures 2014, L.P.

Apple Tree Partners IV, LP

MPM BioVentures V, LP

MPM Asset Management Investors BV5 LLC

David Abramson

ACNYC, LLC

Phil Agnes

Ahlborg Acquisitions LLC

Gilya Alchits

Nigel V. Alexander

Allenwood Ventures, Inc.

Monte D. Anglin and Janet S. Anglin

AR Properties

Ronald Artinian

ARZT, LLC

Jim Aukstuolis

The Bahr Family Limited Partnership

Bao Ning Xie

Raymond F. Barbush III

Sol J. Barer

Martin Becker

Trust of David Benaderet UAD 1/15/13

Stephen Bender

Daniel Blech Trust DTD 8/3/2005

Isaac Blech

Bradley C. Boers

Bozarth LLC

IRA FBO KAREN BRAINARD PERSHING

LLC AS CUSTODIAN ROLLOVER

ACCOUNT

Howard B. Brodsky Revocable Trust of 1988

UAD 10/24/1988

Franklin D. Brown

Ray Alan Bruening

Robert Burke

Leonard J. Calbo and Marguerite Joan Calbo

Adolfo Carmona and Donna Carmona

The Carnahan Trust UAD 08/11/95

Anthony C. Celeste and Barbara Celeste

Richard Cohen

Michael Cohn and Paula Cohn

David S. Cooper

Charles J. Costich and Karin J. Costich

Ben Crown

C Barnes Darwin II

David D Deatkine Jr

Patrick Decavaignac Nancy J Connoly JT

James M. Disiao

James L Dritz

Scott Allen Edelbach Michelle Lynne Edelbach JT

Paul Ehrlich CPA Defined Benefit Plan

Paul
D. Ehrman

Ron Eller and Beth Eller

Douglas L Engers

Steven Farber

Lawrence Feinberg

Frederick A. Fochtman and Linda M. Fochtman

David Foni and Adriana K. Foni

Fortezza Investments, LP

Robert Frankel

David and Debroah Franzetta Trust UAD

1/29/1998

Diana & David Freshwater Living Trust UAS

01/20/04

David L. Frydrych

GBS Ventures, Inc

Keith Gelles

Robert P. Giesen

James B. and Karen A. Glavin Family Trust

UAD 10/30/98; James B. Glavin and Karen A.

Glavin TTEES

Bruce Donald Goethe Laura K Goethe Comm

Prop WROS

Howard M. Haft

Nathan Halegua

John Hawk

Daniel H Hildebrand

Donald E. Hinkle

Joel L. Hochman Revocable Trust

Jing-Zhou Hou

Te-Shao Hsu

IRA FBO Thomas Huang, Pershing LLC as

Custodian

Richard S. Jackson Roth IRA, Pershing LLC as Custodian

JaDaMo LLC

Marc R Jalbert

Robert Kargman and Marjie B. Kargman

William M Kargman

James A Kluge

Thomas C. Kotyk

William S. Lapp

Robert H. Lenox

Todd Loudin

Steven K. Luminais and K. Elizabeth Kindwall

Luminais

Rick D. Mace and Karen J. Mace

Manny Family Revocable Trust UAD 09/17/05

Stanley M Marks

James C. Maylo

Kevin P McCarthy

Robert A. McDonald

Robert A. Melnick

Millenium Trust Co, LLC

Robert C Monks

Reed C. Moskowitz

Fatos
Mucha

Mulkey II Limited Partnership

MSSB C/F David S. Nagelberg IRA Standard

Steven M. Nelson

Northlea Partners LLLP

David Y Norton

The Oaks Family LLC

Colin Offenhartz

David R. Olson

Henry Scovern and Laura K. Pakarow

Panella Living Trust; Joseph Panella & Pamela

Panella Ttees

Jonathan Patronik

Brian D. Petersen and Jane F.S. Petersen

Daniel P Petro

Michael Pierce

Michael E. Portnoy (IRA FBO MICHAEL E

PORTNOY PERSHING LLC AS

CUSTODIAN)

Brian Potiker Revocable Trust UAD 8/7/96

Timothy G. Rahr and Sarah Roman

Raisol, LLC

Kiran Rajasenan and Rosemarie Rajasenan JT

James Ramo 1979 Revocable Trust

Anastasios Raptis and Hariklia Efthimiou JT

Marty L Reich

Mark W. Reutlinger and Analee P. Reutlinger

Comm Prop

Glenn D. Rice (SEP FBO GLENN D RICE

PERSHING LLC AS CUSTODIAN)

Michael Rieber

Brenda A. Riffee Revocable Trust UAD

10/16/06

Stephen E. Riffee Revocable Trust UAD

10/16/06

Dyke Rogers

Thomas M. Rogstad

Michael Paul Ross

Steven Rothstein

Marc A. Rotter

Mark W. Salmon

Joshua Schein 2009 Spearfish Trust UAD

12/28/2009

Peter D. Schiffrin

Alyson D Schlosser

David M. Schneider

David E Schwartz

Anil K Sharma Praguti G Sharma JT

William Sheppard

Estelle Siegel (ESTELLE SIEGEL SEYMOUR SIEGEL JT TEN)

Stuart Silverman

Lawrence Silverstein

Shamus, LLC

Arnold E. Spangler

Richard &
Jeannie Stillman

Clayton A. Struve

Walter Sturm and Sandra Sturm

Min Sun

John D Suryan Monica S Suryan JT

TGR Partners, LLC

James W. Thomas

Transpac Investments Limited

Terrence E Troy

Robert E. Truskowski

Henry M. Tufo and Carleen Tufo

Robert M. Upshaw and Yarima F. Upshaw

Steve Valko

Hans Abel Van Der Laan and Annette Van Der

Laan

G Jan Van Heek

Ted Vanvick

Louis Vigden

Vivari, Ltd

John V. Wagner

Brian D. Warshaw and Randy Warshaw JT

Neil H. Wasserman (SEP FBO NEIL H

WASSERMAN PERSHING LLC AS

CUSTODIAN)

Trust U/W Renee Weiss dtd 05-09-90

Rande R Willsion

Howard J Worman

YKA Partners, Ltd

Kazuaki Yonemoto

Steven A. Yost Roth IRA, Pershing LLC as

Custodian

George Zetinski

Shawn H. Zimberg MD

Lizabeth H. Zlatkus

World Total Return Fund LLLP

Ronald Borchardt

UDI TOLEDANO

David Lawd

Patrick Kolenik

Steven Paul

Richard S. Jackson

Jeff Kurtz

Jerry C. Smith/Vicki S. Smith JTROS

Barbara Slusher

Robert DeSantis

Eugene A. Bauer, M.D.

Cary Sucoff

Blake Paterson

Solomon H. Snyder

 
 

  SCHEDULE A    
    
    Investors    
    

 

			
	New Enterprise Associates 14, L.P.	 	Franklin D. Brown
	NEA Ventures 2014, L.P.	 	Ray Alan Bruening
	Apple Tree Partners IV, LP	 	Robert Burke
	MPM BioVentures V, LP	 	C and A Managed Capital LP
	MPM Asset Management Investors BV5 LLC	 	Leonard J. Calbo and Marguerite Joan Calbo
	2k Limited Partnership	 	Adolfo Carmona and Donna Carmona
	David Abramson	 	The Carnahan Trust UAD 08/11/95
	ACNYC, LLC	 	Anthony C. Celeste and Barbara Celeste
	Phil Agnes	 	Chicago Investments, Inc.
	Ahlborg Acquisitions LLC	 	Richard Cohen
	Gregory M. Alberton	 	Michael Cohn and Paula Cohn
	Gilya Alchits	 	Dennis E. Conklin
	Nigel V. Alexander	 	David S. Cooper
	Allenwood Ventures, Inc.	 	Charles J. Costich and Karin J. Costich
	Monte D. Anglin and Janet S. Anglin	 	Ben Crown
	AR Properties	 	Peter R. Culpepper
	Ronald Artinian	 	C Barnes Darwin II
	ARZT, LLC	 	David D Deatkine Jr
	Jim Aukstuolis	 	Patrick Decavaignac Nancy J Connoly JT
	Evan Azriliant	 	James M. Disiao
	Babst Family Trust UAD 4/01/86	 	Scott V. Dols and Vicki N. Dols
	The Bahr Family Limited Partnership	 	Carl J Domino
	Bao Ning Xie	 	James L Dritz
	The Stanford Baratz Revocable Trust UAD	 	The Dumper Family Trust UAD 05/17/12
	09/07/94; Stanford Baratz and Amy Baratz	 	Janet Dumper & Robert S Dumper Ttees
	TTEES	 	Scott Allen Edelbach Michelle Lynne
	Raymond F. Barbush III	 	Edelbach
	Barclay Armitage	 	JT
	Sol J. Barer	 	Paul Ehrlich CPA Defined Benefit Plan
	BBB Assets, LLC	 	Paul D. Ehrman
	Martin Becker	 	Ron Eller and Beth Eller
	Troy Belle	 	Douglas L Engers
	Trust of David Benaderet UAD 1/15/13	 	Steven Farber
	Stephen Bender	 	Paul A. Fegley
	Daniel Blech Trust DTD 8/3/2005	 	Lawrence Feinberg
	Isaac Blech	 	Gary M. Ferman
	Bradley C. Boers	 	Frederick A. Fochtman and Linda M.
	Bozarth LLC	 	Fochtman
	IRA FBO KAREN BRAINARD PERSHING	 	David Foni and Adriana K. Foni
	LLC AS CUSTODIAN ROLLOVER	 	Fortezza Investments, LP
	ACCOUNT	 	Robert Frankel
	Howard B. Brodsky Revocable Trust of 1988	 	David and Debroah Franzetta Trust UAD
	UAD 10/24/1988	 	1/29/1998
	Diana & David Freshwater Living Trust UAS	 	Kanter Family Foundation
	1/20/2004	 	Robert Kargman and Marjie B. Kargman
	David L. Frydrych	 	William M Kargman
	James B Fryfogle	 	Victor F. Keen
	David J. Galey	 	James A Kluge
	Robert N. Garff	 	Thomas C. Kotyk
	GBS Ventures, Inc	 	William S. Lapp

 

 

 

			
	Keith Gelles	 	Daniel LaRoche
	Wayne Gey	 	Roger S Lash
	Robert P. Giesen	 	Michael D. Leigh
	James B. and Karen A. Glavin Family Trust	 	Robert H. Lenox
	UAD 10/30/98; James B. Glavin and Karen A.	 	Jack E. Leonard and Karen Kay Leonard
	Glavin TTEES	 	Todd Loudin
	Bruce Donald Goethe Laura K Goethe Comm	 	Steven K. Luminais and K. Elizabeth Kindwall
	Prop WROS	 	Luminais
	Gomez Holdings Inc.	 	William Lurie
	Shobha Gopalakrishnan	 	Rick D. Mace and Karen J. Mace
	Mark W. Grinbaum and Tatyana Grinbaum	 	Manny Family Revocable Trust UAD
	Robert Grinberg	 	9/17/05
	Lamar Anderson Gwaltney	 	Marketplace Lofts Limited Partnership
	Howard M. Haft	 	Stanley M Marks
	Nathan Halegua	 	James C. Maylo
	Timothy P Hanley Monica Hanley Ten Com	 	Kevin P McCarthy
	Daniel J. Hartung and Julie A. Hartung JT	 	Robert A. McDonald
	John Hawk	 	Robert A. Melnick
	Jeremiah M. Healy (IRA FBO JEREMIAH M	 	Millenium Trust Co, LLC, Custodian FBO
	HEALY PERSHING LLC AS CUSTODIAN)	 	James H,. Stebbins
	Henry Herzing Revocable Living Trust UAD	 	Robert C Monks
	10/27/93	 	Reed C. Moskowitz
	Daniel H Hildebrand	 	Fatos Mucha
	Donald E. Hinkle	 	David A. Mulkey Limited Partnership II
	Joel L. Hochman Revocable Trust	 	Mulkey II Limited Partnership
	Larry Hopfenspirger	 	MSSB C/F David S. Nagelberg IRA Standard
	Jing-Zhou Hou	 	Steven M. Nelson
	Te-Shao Hsu	 	Northlea Partners LLLP
	IRA FBO Thomas Huang, Pershing LLC as	 	David Y Norton
	Custodian	 	The Oaks Family LLC
	Alexis Hubshman (SEP FBO ALEXIS	 	Colin Offenhartz
	HUBSHMAN PERSHING LLC AS	 	David R. Olson
	CUSTODIAN)	 	Steven H. Oram Revocable Trust
	Richard S. Jackson Roth IRA, Pershing LLC	 	Henry Scovern and Laura K. Pakarow
	as Custodian	 	Panella Living Trust; Joseph Panella & Pamela
	JaDaMo LLC	 	Panella Ttees
	Marc R Jalbert	 	Jonathan Patronik
	JLB Family Trust	 	The Peierls Foundation, Inc.
	Jordan Family LLC	 	Brian Eliot Peierls
	UD Ethel F. Peierls Charitable Lead Trust	 	Stuart Silverman
	E. Jeffrey Peierls	 	Lawrence Silverstein
	Periscope Partners LP	 	Shamus, LLC
	Peter R. Pernicone	 	Arnold E. Spangler
	Brian D. Petersen and Jane F.S. Petersen	 	Bryan S. Spille
	Daniel P Petro	 	Richard & Jeannie Stillman
	Roger Pfohl	 	Richard D. Storer and Jane W. Storer
	Malcolm Phillips	 	Robert Stranger
	Michael Pierce	 	Clayton A. Struve
	Michael E. Portnoy (IRA FBO MICHAEL E	 	Walter Sturm and Sandra Sturm
	PORTNOY PERSHING LLC AS	 	Min Sun
	CUSTODIAN)	 	John D Suryan Monica S Suryan JT
	Brian Potiker Revocable Trust UAD 8/7/96	 	James W Swistock
	Timothy G. Rahr and Sarah Roman	 	TGR Partners, LLC
	Raisol, LLC	 	James W. Thomas

 

 

 

			
	Kiran Rajasenan and Rosemarie Rajasenan JT	 	Gerald A Tomsic Revocable Trust UAD
	James Ramo 1979 Revocable Trust	 	8/10/95
	Anastasios Raptis and Hariklia Efthimiou JT	 	Transpac Investments Limited
	Marty L Reich	 	Terrence E Troy
	Mark W. Reutlinger and Analee P. Reutlinger	 	Robert E. Truskowski
	Comm Prop	 	Henry M. Tufo and Carleen Tufo
	Glenn D. Rice (SEP FBO GLENN D RICE	 	U.S.A. Fund LLLP
	PERSHING LLC AS CUSTODIAN)	 	United Acquisition Corp.
	Michael Rieber	 	Robert M. Upshaw and Yarima F. Upshaw
	Brenda A. Riffee Revocable Trust UAD	 	Steve Valko
	10/16/06	 	Hans Abel Van Der Laan and Annette Van
	Stephen E. Riffee Revocable Trust UAD	 	Der
	10/16/06	 	Laan
	Richard Roehl	 	G Jan Van Heek
	Dyke Rogers	 	Ted Vanvick
	Thomas M. Rogstad	 	Louis Vigden
	Michael Paul Ross	 	Vivari, Ltd
	Steven Rothstein	 	James Vornov
	Marc A. Rotter	 	John V. Wagner
	Mark W. Salmon	 	Brian D. Warshaw and Randy Warshaw JT
	Joshua Schein 2009 Spearfish Trust UAD	 	Neil H. Wasserman (SEP FBO NEIL H
	12/28/2009	 	WASSERMAN PERSHING LLC AS
	Peter D. Schiffrin	 	CUSTODIAN)
	Alyson D Schlosser	 	Wealth Concepts, LLC
	David M. Schneider	 	Trust U/W Renee Weiss dtd 05-09-90
	David E Schwartz	 	Kenneth Widelitz (IRA FBO KENNETH
	Anil K Sharma Praguti G Sharma JT	 	WIDELITZ PERSHING LLC AS
	William Sheppard	 	CUSTODIAN)
	Estelle Siegel (ESTELLE SIEGEL	 	Widelitz Family Trust UAD 4/15/94
	SEYMOUR SIEGEL JT TEN)	 	Rande R Willsion
	Seth Siegel	 	Howard J Worman
	Chilakamarri Yeshwant Trust	 	 
	YKA Partners, Ltd	 	 
	Kazuaki Yonemoto	 	 
	Steven A. Yost Roth IRA, Pershing LLC as	 	 
	Custodian	 	 
	George Zetinski	 	 
	Shawn H. Zimberg MD	 	 
	Lizabeth H. Zlatkus	 	 

 

 

QuickLinks

Exhibit 4.1

SECOND AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT

TABLE OF CONTENTS

SECOND AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT

RECITALS

1. Definitions.

2. Registration Rights.

2.1 Demand Registration .

(a)  Form S-1 Demand .

(b)  Form S-3 Demand .

2.2 Company Registration .

2.3 Underwriting Requirements .

2.4 Obligations of the Company.

2.5 Furnish Information.

2.6 Expenses of Registration.

2.7 Delay of Registration.

2.8 Indemnification.

2.9 Reports Under Exchange Act.

2.10 Limitations on Subsequent Registration Rights.

2.11 "Market Stand-off" Agreement.

2.12 Restrictions on Transfer.

2.13 Termination of Registration Rights.

3. Information and Observer Rights.

3.1 Delivery of Financial Statements.

3.2 Inspection.

3.3 Observer Rights.

3.4 Termination of Information Rights.

3.5 Confidentiality.

4.1 Right of First Offer.

4.2 Termination.

5.1 Insurance.

5.2 Employee Agreements.

5.3 Employee Stock.

5.4 Qualified Small Business Stock.

5.5 Successor Indemnification.

5.6 Expenses of Counsel.

5.7 Indemnification Matters.

5.8 Right to Conduct Activities.

5.9 FCPA.

5.10 FIRPTA.

5.11 Termination of Covenants.

6.1 Successors and Assigns.

6.2 Governing Law.

6.3 Counterparts.

6.4 Titles and Subtitles.

6.5 Notices.

6.6 Amendments and Waivers.

6.7 Severability.

6.8 Aggregation of Stock.

6.9 Additional Investors.

6.10 Entire Agreement.

6.11 Dispute Resolution.

6.12 Waiver of Jury Trial.

6.13 Delays or Omissions.

6.14 Acknowledgment.

SCHEDULE A InvestorsQuickLinks
 -- Click here to rapidly navigate through this document

 

 
 

  Exhibit 4.3    
    

          THE WARRANT REPRESENTED HEREBY AND THE COMMON STOCK OR OTHER SECURITIES ISSUABLE UPON THE EXERCISE HEREOF HAVE NOT BEEN REGISTERED
UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE "ACT"), OR ANY STATE SECURITIES LAWS AND NEITHER THIS WARRANT NOR THE COMMON STOCK OR OTHER SECURITIES ISSUABLE UPON THE EXERCISE HEREOF NOR
ANY INTEREST THEREIN MAY BE TRANSFERRED IN THE ABSENCE OF SUCH REGISTRATION OR AN EXEMPTION THEREFROM UNDER SUCH ACT AND SUCH LAWS AND THE RULES AND REGULATIONS THEREUNDER. THE SECURITIES REPRESENTED
BY THIS CERTIFICATE ARE SUBJECT TO THE PROVISIONS OF AN AMENDED AND RESTATED INVESTORS' RIGHTS AGREEMENT, AN AMENDED AND RESTATED VOTING AGREEMENT AND AN AMENDED AND RESTATED RIGHT OF FIRST REFUSAL
AND CO-SALE AGREEMENT, EACH DATED AS OF [    ·    ], 2013 (COPIES OF WHICH ARE ON
FILE WITH THE SECRETARY OF THE COMPANY) AND MAY NOT BE SOLD, TRANSFERRED, ASSIGNED, PLEDGED, HYPOTHECATED OR OTHERWISE DISPOSED OF EXCEPT IN COMPLIANCE WITH THE PROVISIONS OF SUCH AMENDED AND RESTATED
INVESTORS' RIGHTS AGREEMENT, AMENDED AND RESTATED VOTING AGREEMENT AND AMENDED AND RESTATED RIGHT OF FIRST REFUSAL AND CO-SALE AGREEMENT. 

 

			
	 Warrant No. [·]
	 	Dated: [·], 2013

 

  
 

  COMMON STOCK WARRANT
  
    CERECOR INC.    
    

          THIS IS TO CERTIFY THAT for value received, [HOLDER'S NAME], a  [ENTITY TYPE]
formed under the laws of the State of  [STATE] (the "Holder"), is entitled, subject to the terms and conditions set
forth below, to purchase from Cerecor Inc., a Delaware corporation (the "Company"), the Warrant Shares (as defined in Section 1(h) below),
at a price per share equal as set forth in Section 1(g) below (the "Exercise Price"). This warrant (this
"Warrant") is being issued in connection with the purchase of shares of Series A-1 Preferred Stock of the Company pursuant to a Series A-1
Preferred Stock and Warrant Purchase Agreement, dated on or about the date hereof, by and among the Company, the Holder and the other parties thereto (the "Purchase
Agreement"). All Warrants issued under the Purchase Agreements are referred to herein, collectively, as the "Warrants." The
Holder, collectively with all Holders of other Warrants, are sometimes referred to collectively as the "Holders." 

          Capitalized
terms used but not otherwise defined herein shall have the meanings given to them in the Purchase Agreements. 

          1.    Manner of Exercise; Expiration Date.    

          (a)    This Warrant shall be exercisable in accordance with this Section 1 and Section 2 below from and after the
date hereof until 5:00 p.m., New York time on the fifth (5th) anniversary of the date hereof (the "Exercise Period"). The Holder may from time to
time during the Exercise Period on any business day exercise this Warrant, for all or any part of the Warrant Shares purchasable at such time hereunder, by delivering to the Company at its principal
office (i) a written notice of the Holder's election to exercise this Warrant (an "Exercise Notice"), which Exercise Notice shall be irrevocable
and shall specify the number of Warrant Shares to be purchased, (ii) payment of the aggregate Exercise Price for the applicable number of Warrant Shares to be purchased by check or wire
transfer of immediately available funds to an account then specified by the Company and (iii) this Warrant (the date on which the foregoing items are delivered to the Company being hereinafter
referred to as the "Exercise Date"). Such Exercise Notice shall be in the form of Annex A hereto, duly executed by the Holder or its duly
authorized agent. 

1

 

          (b)    Upon receipt of the items specified in Section 1(a), the Company shall execute (or cause to be executed) and
deliver (or cause to be delivered) to the Holder a certificate or certificates representing the aggregate number of full Warrant Shares issuable upon such exercise, together with cash in lieu of any
fraction of a share, as hereafter provided. This Warrant shall be deemed to have been exercised and such certificate or certificates shall be deemed to have been issued, and the Holder shall be deemed
to have become a Holder of record of such shares for all purposes, as of the Exercise Date. 

          (c)    If this Warrant is exercised in part, the Company shall, at the time of delivery of the certificate or certificates
representing the Warrant Shares being issued, deliver to the Holder a new Warrant evidencing the rights of the Holder to purchase the unpurchased Warrant Shares called for by this Warrant. Such new
Warrant shall in all other respects be identical to this Warrant. 

          (d)    The Company shall pay any and all issue and other taxes (other than income taxes) that may be payable in respect of the
issuance of this Warrant or any issuance or delivery of Warrant Shares on exercise of this Warrant; provided, however, that the Company shall not be obligated to pay any transfer taxes resulting from
any transfer requested by the Holder of record of this Warrant in connection with any such exercise. 

          (e)    The Company shall at all times reserve and keep available out of its authorized but unissued shares of capital stock,
solely for the purpose of effecting the exercise of this Warrant, such number of its shares of capital stock as shall from time to time be sufficient to effect such exercise of this Warrant for the
maximum number of shares of such class or series of capital stock issuable upon exercise of this Warrant; and if at any time the number of authorized but unissued shares of such capital stock shall
not be sufficient to effect such exercise of this Warrant for the maximum number of shares of such capital stock then issuable upon exercise hereunder, the Company will take such corporate action as
may, in the opinion of its counsel, be necessary to increase its authorized but unissued shares of such capital stock to such number of shares as shall be sufficient for such purpose, including,
without limitation, engaging in best efforts to obtain the requisite stockholder approval of any necessary amendment to the Company's Certificate of Incorporation (as amended from time to time). The
Company will not at any time close its stock transfer books in a manner which prevents the timely exercise of this Warrant. 

          (f)    No fractional shares shall be issued upon the exercise of this Warrant. All shares of capital stock (including fractions
thereof) issuable upon exercise of this Warrant as to each share of capital stock shall be aggregated for purposes of determining whether the exercise would result in the issuance of any fractional
shares. If, after the aforementioned aggregation, the exercise would result in the issuance of a fraction of a share of capital stock, the Company shall, in lieu of issuing any fractional share, pay
the Holder a sum of cash equal to the fair market value (as described in Section 2 below) of such fraction on the date of exercise. 

          (g)    During the period from issuance until the IPO Penalty Date (as defined in the Amended and Restated Certificate of
Incorporation (the "Restated Charter")), (i) in the event the Company has consummated a Qualified IPO (as defined in the Restated Charter) on or
before the Exercise Date, the Exercise Price shall be the public offering price per share in such Qualified IPO, and (ii) in the event the
Company has not completed a Qualified IPO on or before the Exercise Date, the Exercise Price shall be $1.00, in case of each of foregoing clauses (i) and (ii), subject to further adjustment
pursuant to Section 3 hereof. From and after the IPO Penalty Date, the Exercise Price shall be $1.00, subject to further adjustment pursuant to Section 3 hereof. 

2

 

          (h)    "Warrant Shares" means a number of shares of common stock, par value
$0.001 per share, of the Company ("Common Stock") equal to [                 ](1) (the "Initial Warrant
Shares"); provided that: 

          (i)     if the Company does not file a registration statement with the Securities and Exchange Commission under the
Securities Act of 1933, as amended, with respect to a Qualified IPO on or before Registration Penalty Date (as defined in the Restated Charter), then the number of Warrant Shares shall increase by an
additional 20% of the Initial Warrant Shares starting on the Registration Penalty Date, and on each monthly anniversary of the Registration Penalty Date thereafter during the continuance of such
failure to file, the number of Warrant Shares shall increase by an additional 20% of the Initial Warrant Shares until the number of Warrant Shares reaches an amount equal to the Initial Warrant Shares  multiplied
by 2 (the "Maximum Warrant Shares"), after which it shall be capped and will no longer
increase. 

          (ii)    if the Corporation does not complete a Qualified IPO on or before the IPO Penalty Date (as defined in the Restated
Charter), then the number of Warrant Shares shall increase by an additional 20% of the Initial Warrant Shares starting on the IPO Penalty Date, and on each monthly anniversary of the IPO Penalty Date
thereafter during the continuance of such failure to complete a Qualified IPO, the number of Warrant Shares shall increase by an additional 20% of the Initial Warrant Shares until the number of
Warrant Shares reaches an amount equal to the Maximum Warrant Shares, after which it shall be capped and will no longer increase. 

          (iii)  notwithstanding the foregoing, in no case shall the number of Warrant Shares exceed the number of Maximum Warrant
Shares. 

          (iv)   notwithstanding the foregoing, in the event a registration statement filed by the Company pursuant to the Securities
Exchange Act of 1934, as amended, becomes effective on or before the Registration Penalty Date, then the number of Warrant Shares will be capped at the number of Initial Warrant Shares and shall not
increase at any time under any condition of this Section 1(h), including Section 1(h)(i) or 1(h)(ii) above. 

          2.    Net Exercise Issue.    Notwithstanding any provision herein to the contrary, if the fair market value of one
share of Common Stock is greater than the Exercise Price (at the date of calculation as set forth below), in lieu of exercising this Warrant for cash, the Holder may elect to receive shares equal to
the value (as determined below) of this Warrant (or the portion thereof being canceled) by surrender of this Warrant at the principal office of the Company together with the properly endorsed Exercise
Notice in which event the Company shall issue to the Holder a number of shares of Common Stock computed using the following formula: 

 

										
	 	 
	 	X	 	=	 	Y (A–B)

A	 	 
	 	 Where
	 	X	 	=	 	the number of Warrant Shares to be issued to the Holder
	 	 
	 	Y	 	=	 	the number of Warrant Shares with respect to which this Warrant is being exercised
	 	 
	 	A	 	=	 	the fair market value of one share of Common Stock (at the date of such calculation)
	 	 
	 	B	 	=	 	Exercise Price (as adjusted to the date of such calculation)

 

           For
purposes of the above calculation, the fair market value of one share of Common Stock shall be: 

          (a)    the average daily Market Price (as defined below) during the period of the most recent 10 trading days, ending on the
last business day before the effective date of exercise of the Warrant, on which the national securities exchanges or over-the-counter market in which the 

   

   

 

 	(1)
	Equal
to 25% of the number of shares of Series A-1 Preferred Stock purchased by such investor. 

3

 

shares
of Common Stock is quoted were open for trading. If the Common Stock is traded on a national securities exchange or admitted to unlisted trading privileges on such an exchange, or is quoted on
the NASDAQ Stock Market, the Market Price as of a specified day shall be the last reported sale price of Common Stock on such exchange or on the NASDAQ on such date or if no such sale is made on such
day, the mean of the closing bid and asked prices for such day on such exchange or on the NASDAQ (the "Market Price"); or 

          (b)    if the Common Stock is not then listed or admitted to trading on any national securities exchange or quoted on the
NASDAQ Stock Market, the fair market value shall be determined in good faith by the Board of Directors of the Company. 

          3.    Adjustments for Stock Dividends, Splits, etc.    If the Company declares or pays a dividend on the outstanding
shares of the Common Stock or other securities, then upon exercise of this Warrant, for each Warrant Share acquired, Holder shall receive, without cost to Holder, the total number and kind of
securities to which Holder would have been entitled had Holder owned the Warrant Shares of record as of the date the dividend occurred. If the Company subdivides the outstanding shares of Common Stock
by reclassification or otherwise into a greater number of shares, the number of Warrant Shares purchasable hereunder shall be proportionately increased and the Warrant Price shall be proportionately
decreased. If the outstanding shares of Common Stock are combined or consolidated, by reclassification or otherwise, into a lesser number of shares, the Warrant Price shall be proportionately
increased and the number of Warrant Shares shall be proportionately decreased. 

          4.    Fractional Shares.    No fractional Warrant Shares shall be issuable upon exercise or conversion of the Warrant
and the number of Warrant Shares to be issued shall be rounded down to the nearest whole Warrant Share. If a fractional share interest arises upon any exercise or conversion of the Warrant, the
Company shall eliminate such fractional share interest by paying Holder the amount computed by multiplying the fractional interest by the fair market value of a full Warrant Share. 

          5.    Replacement of Warrant.    On receipt of evidence reasonably satisfactory to the Company of the loss, theft,
destruction or mutilation of this Warrant and, in the case of any such loss, theft or destruction of this Warrant, on delivery of an indemnity agreement reasonably satisfactory in form and amount to
the Company or, in the case of any such mutilation, on surrender and cancellation of this Warrant, the Company at its expense will execute and deliver, in lieu thereof, a new Warrant of like tenor. 

          6.    Negotiability, etc.    This Warrant is issued upon the following terms, all of which the Holder hereof by the
taking hereof consents and agrees: 

          (a)    The Holder shall not be entitled to pledge, mortgage, transfer, endorse or otherwise convey this Warrant (a
"Transfer"), in whole or in part, except (i) in accordance with the provisions of the Amended and Restated Right of First Refusal and Co-Sale
Agreement or (ii) the prior written consent of the Company. To the extent permitted by the preceding sentence, the Holder and its direct and indirect transferees may Transfer all or any portion
of this Warrant by surrendering this Warrant to the Company together with a completed assignment in the form attached hereto as Annex B. Upon such surrender, the Company shall deliver a new
Warrant or Warrants to the person or persons entitled thereto and, if applicable, shall deliver to Holder a new Warrant evidencing the right of Holder to purchase the balance of the Warrant Shares
subject to purchase hereunder. The term "Holder" as used herein shall include any transferee to whom this Warrant has been Transferred in accordance with this Section 6. 

          (b)    The Holder shall not be entitled to vote or to receive dividends or to be deemed the Holder of capital stock that may at
any time be issuable upon exercise of this Warrant for any purpose whatsoever, nor shall anything contained herein be construed to confer upon the Holder any of the rights of a stockholder of the
Company or any right to vote for the election of directors or upon any matter submitted to stockholders at any meeting thereof, or to give or withhold 

4

 

consent
to any corporate action (whether upon any recapitalization, issuance or reclassification of stock, change of par value or change of stock to no par value, consolidation, merger or conveyance
or otherwise), or to receive notice of meetings, or to receive dividends or subscription rights, until the Holder shall have exercised this Warrant and been issued shares of capital stock in
accordance with the provisions hereof. 

          (c)    Neither this Warrant nor any shares of capital stock or other securities purchased pursuant to this Warrant have been
registered under the 1933 Act and applicable state securities laws. Therefore, the transfer or exchange of this Warrant or such shares may be made only in a transaction permitted under the 1933 Act
and applicable state securities laws or pursuant to an exemption therefrom. Prior to registration, the certificates evidencing the Warrant Shares or other securities issued on the exercise of this
Warrant shall bear a legend to the effect that the shares evidenced by such certificates have not been registered under the 1933 Act and applicable state securities laws. 

          (d)    Until this Warrant is transferred on the books of the Company, the Company may treat the registered Holder hereof as the
absolute owner hereof for all purposes, notwithstanding any notice to the contrary. 

          7.    Notices, etc.    All notices and other communications from the Company to the Holder of this Warrant shall be
sent by facsimile or overnight courier or shall be mailed by first class registered or certified mail, postage prepaid, at such address as may have been furnished to the Company in writing by such
Holder or, until any such Holder furnishes to the Company an address, then to, and at the address of, the last Holder of this Warrant who has so furnished an address to the Company. All such notices
and communications shall, when mailed, be effective when deposited in the mails and, when sent by facsimile or overnight courier, delivered, be effective when received. 

          8.    Amendments.    This Warrant and any term hereof may be changed, waived, discharged or terminated only by an
instrument in writing signed by the party against which enforcement of such change, waiver,
discharge or termination is sought; provided, that the holders of a majority of the aggregate Warrant Shares issued under the Purchase Agreement and then outstanding shall have the right to act on
behalf of all Holders of Warrants with respect to all Warrants. 

          9.    Governing Law.    This Warrant shall be construed and enforced in accordance with and governed by the laws of
the State of Delaware without regard to the laws that might be applied under any conflict of laws principles. 

          10.    Headings.    The headings in this Warrant are for purposes of reference only, and shall not limit or otherwise
affect any of the terms hereof. 

          11.    Severability.    The invalidity or unenforceability of any provision hereof shall in no way affect the
validity or enforceability of any other provision. 

          [END OF TEXT. SIGNATURE PAGE FOLLOWS.]

5

 

          IN WITNESS WHEREOF, the Company has caused this Warrant to be executed by a duly authorized officer as of the date first written above. 

 

							
	 
	 	 CERECOR INC.
	

 
	
 	
 By:	
 	
  

 
	 
	 	 	 	Name:	 	Blake M. Paterson
	 
	 	 	 	Title:	 	 Chief Executive Officer

 

 6

 

 

 
 

  ANNEX A    
    
    FORM OF EXERCISE NOTICE    
    

(To
be executed if Holder desires to exercise the Warrants evidenced by this Warrant Certificate). 

TO
CERECOR INC.  

	o
	The
undersigned hereby (1) irrevocably elects to exercise             Warrant Shares represented by
this Warrant to purchase             shares of Common Stock issuable upon the exercise of such Warrant, (2) makes payment in full of the aggregate Exercise Price for such Warrants
by
enclosure of a certified or bank cashier's check therefor, upon condition that a new Warrant be issued for the balance of the Warrant Shares remaining, if any, and (3) requests that a
certificate for the shares of Common Stock purchased hereunder be issued in the name of and delivered to: 

(Please
print name and address)  

	o
	The
undersigned hereby elects to convert              percent (         %) of the value of the
Warrant pursuant to the provisions of Section 2 of the Warrant. 

          If such number of Warrant Shares not be all of the Warrant Shares evidenced by this Warrant Certificate, a new Warrant for the balance remaining of such Warrant
Shares shall be registered in the name of and delivered to: 

(Please
print name and address) 

 

					
	Dated:	 	      

 	 	 
	
 Signature:	
 	
     

 	
 	
 

 

 7

 
 
 

  ANNEX B    
    
    FORM OF ASSIGNMENT    
    

(To
be executed by the registered Holder if such Holder desires to transfer the attached Warrant.) 

          FOR
VALUE RECEIVED,             hereby sells, assigns, and transfers unto             a Warrant to
purchase             shares of common stock, par value $0.001 per share,
of Cerecor Inc., a Delaware corporation (the "Company"), together with all right, title, and interest therein, and does hereby irrevocably
constitute and appoint             attorney to transfer such Warrant on the books of the Company, with full power of substitution. 

          The
undersigned represents, unless the sale of this Warrant has been registered under the Securities Act of 1933, as amended (the "Securities
Act"), that the undersigned is acquiring such Warrant for its own account for investment and not with a view to or for sale in connection with any distribution thereof (except
for any resale pursuant to a Registration Statement under the Securities Act). 

 

					
	Dated:	 	      

 	 	 
	
 Signature:	
 	
     

 	
 	
 

 

 8

 

 
 

  CERECOR INC.
  
    AMENDMENT TO COMMON STOCK WARRANTS    
    

          This AMENDMENT TO COMMON STOCK WARRANTS (this
"Amendment") is made as of July 11, 2014, by and among Cerecor Inc. (the "Company") and
the holders of Warrants (as defined below) that are signatories hereto (the "Holders"). 

 
 

RECITALS    
    

          WHEREAS, the Company previously issued certain warrants (the
"Warrants") to purchase shares of its common stock, par value $0.001 per share ("Common Stock"), to the
Holders pursuant to that certain Series A-1 Preferred Stock and Warrant Purchase Agreement, dated August 23, 2013 (the "Purchase
Agreement"); 

          WHEREAS, Section 8 of each of the Warrants provides that the holders of a majority of the aggregate Warrant Shares (as defined in
the Warrants) issued under the Purchase Agreement and currently outstanding (the "Requisite Majority") shall have the right to act on behalf of all
Holders of Warrants with respect to the amendment of all Warrants; 

          WHEREAS, the undersigned Holders constitute the Requisite Majority; 

          WHEREAS, the Company and the Holders hereby desire to amend the each of the Warrants as set forth below. 

          NOW, THEREFORE, for good and valuable consideration, the sufficiency of which is hereby acknowledged, the parties hereto agree as
follows: 

	1.
	Section 1.(g)
of each Warrant is hereby deleted in its entirety and the following is substituted in lieu thereof: 

          "The
Exercise Price shall be $1.00, subject to adjustment pursuant to Section 3 hereof."  

	2.
	Section 1.(h)
of each Warrant is hereby amended to (A) delete Sections 1.(h)(i), 1.(h)(ii), 1.(h)(iii) and 1.(h)(iv) thereof;
(B) delete "(the "Initial Warrant Shares"); provided that:", in the first sentence of
Section 1.(h), and (C) to add a period at the end of such sentence.

	3.
	This
Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which together shall constitute one and
the same instrument. The Amendment may be executed by facsimile signatures.

	4.
	This
Amendment shall be governed by and construed in accordance with the laws of the State of Delaware without regard to principles of conflicts of laws that
would result in the application of the law of any other jurisdiction.

	5.
	Except
as specifically amended by this Amendment, all other terms and conditions of the Warrant shall remain in full force and effect in accordance with its
terms without modification. 

[END OF TEXT. SIGNATURE PAGES FOLLOW.]

9

 

					
	 CERECOR INC.:	 	 
	

/s/ BLAKE PATERSON

 	
 	
 
	Name:	 	Blake Paterson	 	 
	Title:	 	 Chief Executive Officer	 	 

 

   

   

  SIGNATURE PAGE TO CERECOR INC. AMENDMENT TO COMMON STOCK WARRANTS

Signed by the following Holders:  

Allenwood
Ventures, Inc.

Michael Cohn and Paula Cohn

David Abramson

Monte D Anglin & Janet S Anglin

Henry Scovern and Laura K. Pakarow

Ron Eller and Beth Eller

Charles J. Costich and /s/ Karin J. Costich

Anil K. Sharma and Pragati G. Sharma JT TEN

David S. Cooper

Robert P. McDonald

Millenium Trust Co, LLC

Ahlborg Acquisitions, LLC

James M. Diasio

Thomas C. Kotyk

James A. Kluge

Clayton A. Struve

John V. Wagner

Howard M. Haft

Todd Loudin

Sol J. Barer

Raymond Barbush

Paul D. Ehrman

Min Sun

Bruce Donald Goethe Laura K. Goethe Comm Prop WROS

James L. Dritz

Franklin D. Brown

Mark R. Jalbert

Jing-Zhou Hou

Donald E. Hinkle

Terrence E. Troy

Stanley M. Marks

Douglas L Engers

John D. Suryan and Monica S. Suryan JT TEN

Rick D. Mace and Karen J. Mace

JaDaMo, LLC

Nathan Halegua

Reed Moskowitz

Adolfo Carmona and Donna Carmona

Patrick Decavaignac and Nancy J Connolly JT

Diana and David Freshwater Living Trust UAS 1/20/04

Brian Potiker Revocable trust uad 8/7/96

Joshua Schein 2009 Spearfish Trust

GBS Ventures

Steven A. Yost IRA

David & Deborah Franzetta Trust UAD 1/29/98

George Zelinski

David De Atkine Jr

Richard Cohen

Stephen Bender

David M. Schneider

Colin Offenhartz

Steven Nelson

Kazuaki
Yonemoto

Henry Tufo/Carleen Tufo

Robert E. Truskowski

Jonathan Patronik

Daniel Hildebrand

John Hawk

C. Barnes Darwin II

Jim Aukstuolis

Alyson D. Schlosser

William Sheppard

Gilya Alchits

Thomas M. Rogstad

Ted Vanvick

David L. Frydrych

David York Morrow

James Ramo 1979 Revocable Trust

Panella Living Trust; Joseph Panella and Pamela Panella TTEES

Robert P. Giesen

Kiran Rajasenan and Rosemarie Rajasenan JT

Trust U/W Renee Weiss

Shamus, LLC

Robert A. Melnick

Steven Rothstein

Robert C. Monks

Fortezza Investments, LP

The Bahr Family Limited Partnership

Steven Farber

Dyke Rogers

VIVARI, LTD

Richard Cohen

Trust of David Benaderet UAD 1/15/13

William S. Lapp

James B. and Karen A. Glavin Family UAD 10/30/98; James B. Glavinand Karen A. Glavin TTEES

Jerry C. Smith/Vicki S. Smith JTROS

A R Properties

ARZT, LLC

Robert Burke

Martin Lorne Reich

Robert H. Lenox

Kevin P. Mccarthy

Keith Gelles

Shawn H. Zimberg MD

Ronald Artinian

William B. Kargman

Robert Frankel

Louis Vigden

David Y. Norton

Daniel P. Petro

Michael Pierce

Neil H. Wasserman

World Total Return Fund LLLP

Richard S. Jackson Roth IRA Pershing LLC as Custodian

Joel L. Hochman Revocable Trust

The Carnahan Trust UAD 08/11/95

IRA
FBO Thomas Huang Pershing LLC as Custodian

Anastasios Raptis and Hariklia Efthimiou JT

Steven K. Luminais and. Elizabeth Kindwall Luminais

Scott Allen Edelbach andMichelle Lynn Edelbach JT TEN

Brian D. Warshaw and Randy Warshaw

Leonard J. Calbo and Marguerite Joan Calbo

G Jan Van Heek

Te-Shao Hsu

Peter Schiffrin

Lizabeth H. Zlatkus

Richard R. Willison

Howard J Worman

Arnold E. Spangler

Robert P. Giesen

Lawrence I. Silverstein 

QuickLinks

Exhibit 4.3

COMMON STOCK WARRANT CERECOR INC.

ANNEX A FORM OF EXERCISE NOTICE

ANNEX B FORM OF ASSIGNMENT

CERECOR INC. AMENDMENT TO COMMON STOCK WARRANTS

RECITALS

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