Document:

EX-10.3

 Exhibit 10.3 

Execution Version 

SIENNA BIOPHARMACEUTICALS, INC. 

AMENDED AND RESTATED 

INVESTORS’ RIGHTS AGREEMENT 

April 12, 2017 
  

 TABLE OF CONTENTS 

 

									
	 	 	 	  	 	  	Page	 
	1.	 	 Definitions
	  	 	2	 
			
	2.	 	 Registration Rights
	  	 	5	 
		 	2.1	  	Demand Registration	  	 	5	 
		 	2.2	  	Company Registration	  	 	7	 
		 	2.3	  	Underwriting Requirements	  	 	7	 
		 	2.4	  	Obligations of the Company	  	 	8	 
		 	2.5	  	Furnish Information	  	 	10	 
		 	2.6	  	Expenses of Registration	  	 	10	 
		 	2.7	  	Delay of Registration	  	 	10	 
		 	2.8	  	Indemnification	  	 	11	 
		 	2.9	  	Reports Under Exchange Act	  	 	13	 
		 	2.10	  	Limitations on Subsequent Registration Rights	  	 	13	 
		 	2.11	  	“Market Stand-off” Agreement	  	 	14	 
		 	2.12	  	Restrictions on Transfer	  	 	15	 
		 	2.13	  	Termination of Registration Rights	  	 	16	 
			
	3.	 	 Information and Observer Rights
	  	 	16	 
		 	3.1	  	Delivery of Financial Statements	  	 	16	 
		 	3.2	  	Inspection	  	 	18	 
		 	3.3	  	Observer Rights	  	 	18	 
		 	3.4	  	Termination of Information and Observer Rights	  	 	18	 
		 	3.5	  	Confidentiality	  	 	19	 
		 	3.6	  	“Bad Actor” Covenant	  	 	19	 
			
	4.	 	 Rights to Future Stock Issuances
	  	 	19	 
		 	4.1	  	Right of First Offer	  	 	19	 
		 	4.2	  	Termination	  	 	21	 
			
	5.	 	 Additional Covenants
	  	 	21	 
		 	5.1	  	Insurance	  	 	21	 
		 	5.2	  	Employee Agreements	  	 	21	 
		 	5.3	  	Employee Stock	  	 	21	 
		 	5.4	  	Matters Requiring Investor Director Approval	  	 	22	 
		 	5.5	  	Board Matters	  	 	23	 
		 	5.6	  	Successor Indemnification	  	 	23	 
		 	5.7	  	Expenses of Counsel	  	 	23	 
		 	5.8	  	Indemnification Matters	  	 	24	 
		 	5.9	  	Right to Conduct Activities	  	 	24	 
		 	5.10	  	Tax Reporting	  	 	25	 
		 	5.11	  	Termination of Covenants	  	 	25	 

  
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	6.	 	 Miscellaneous
	  	 	25	 
		 	6.1	  	Successors and Assigns	  	 	25	 
		 	6.2	  	Governing Law	  	 	26	 
		 	6.3	  	Counterparts	  	 	26	 
		 	6.4	  	Titles and Subtitles	  	 	26	 
		 	6.5	  	Notices	  	 	26	 
		 	6.6	  	Amendments and Waivers	  	 	27	 
		 	6.7	  	Severability	  	 	27	 
		 	6.8	  	Aggregation of Stock	  	 	27	 
		 	6.9	  	Additional Investors	  	 	27	 
		 	6.10	  	Entire Agreement	  	 	28	 
		 	6.11	  	Dispute Resolution	  	 	28	 
		 	6.12	  	Waiver of Jury Trial	  	 	28	 
		 	6.13	  	Delays or Omissions	  	 	29	 
		 	6.14	  	Acknowledgment	  	 	29	 
		 	6.15	  	Massachusetts Business Trust	  	 	29	 

  

					
	 Schedule A
	  	-	  	Schedule of Investors
	 Schedule B
	  	-	  	Schedule of Key Holders

  

  
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 AMENDED AND RESTATED 

INVESTORS’ RIGHTS AGREEMENT 

THIS AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT (this “Agreement”), is made as of April 12, 2017, by and
among Sienna Biopharmaceuticals, Inc., a Delaware corporation (the “Company”), each of the investors listed on Schedule A hereto, each of which is referred to in this Agreement as an “Investor,” and each of
the stockholders listed on Schedule B hereto, each of whom is referred to herein as a “Key Holder.” 
 RECITALS

 WHEREAS, certain of the Investors (the “Existing Investors”) hold shares of the Company’s Series A-1 Preferred Stock, Series A-2 Preferred Stock, Series A-3 Preferred Stock and/or Common Stock and possess registration rights,
information rights, rights of first offer, and other rights pursuant to an Amended and Restated Investors’ Rights Agreement dated as of October 8, 2015 by and among the Company and such Investors (as amended, the “Prior
Agreement”). 
 WHEREAS, pursuant to Section 6.6 of the Prior Agreement, any term of the Prior Agreement may be amended
and the observance of any term of the Prior Agreement may be waived (either generally or in a particular instance, and either retroactively or prospectively) with the written consent of the Company and the holders of a majority of the Registrable
Securities then outstanding (the “Requisite Investors”), provided that the Prior Agreement may not be amended, and no provision of the Prior Agreement may be waived, in each case, in any way which would adversely affect the rights
of the Key Holders under the Prior Agreement in a manner disproportionate to any adverse effect such amendment or waiver would have on the rights of the Investors under the Prior Agreement, without the written consent of the holders of at least a
majority of the Registrable Securities held by the Key Holders (the “Requisite Key Holders” and together with the Requisite Investors, the “Requisite Parties”). 

WHEREAS, the Company, the undersigned Existing Investors, constituting the Requisite Investors, and the undersigned Key Holders,
constituting the Requisite Key Holders, desire to amend and restate the Prior Agreement in its entirety and to accept the rights created pursuant to this Agreement in lieu of the rights granted to them under the Prior Agreement. 

WHEREAS, certain of the Investors are parties to that certain Series B Preferred Stock Purchase Agreement of even date herewith by and
among the Company and certain of the Investors (as may be amended from time to time, the “Purchase Agreement”), under which certain of the Company’s and such Investors’ obligations are conditioned upon the execution and
delivery of this Agreement by such Investors, Existing Investors and the Company. 
 AGREEMENT 

NOW, THEREFORE, the Company and the undersigned Existing Investors and Key Holders, constituting the Requisite Parties, hereby agree
that the Prior Agreement shall be amended and restated in its entirety by this Agreement, and the parties to this Agreement further agree as follows: 

 1. Definitions. For purposes of this Agreement: 

“Affiliate” means, with respect to any specified Person, any other Person who, directly or indirectly, controls, is controlled
by, or is under common control with such Person, including without limitation any general partner, managing member, officer or director of such Person or any venture capital fund or other investment fund now or hereafter existing that is controlled
by one or more general partners or managing members of, or shares the same management company with, such Person. 
 “Affiliated
Fund” means with respect to (i) a limited liability company or a limited liability partnership, a fund or entity managed by the same manager or managing member or general partner or management company or by an entity controlling,
controlled by, or under common control with such manager or managing member or general partner or management company, and (ii) an investment company registered under the Investment Company Act of 1940, as amended, advised by Fidelity or any
affiliated investment advisor of Fidelity, one or more mutual fund, pension fund, pooled investment vehicle or institutional client advised by Fidelity or any affiliated investment advisor of Fidelity, in each case, registered under the Investment
Advisers Act of 1940. 
 “Common Stock” means shares of the Company’s common stock, par value $0.0001 per share. 

“Competitor” means, as of any date, a Person engaged, directly or indirectly (including through any partnership,
limited liability company, corporation, joint venture or similar arrangement (whether now existing or formed hereafter)), in the business conducted or proposed to be conducted by the Company on such date, but shall not include any financial
investment firm or collective investment vehicle that, together with its Affiliates, holds less than twenty percent (20)% of the outstanding equity of any Competitor and does not, nor do any of its Affiliates, have a right to designate any members
of the Board of Directors of any Competitor; provided, however, that under no circumstances shall any Fidelity Entity be considered a Competitor. 

“Damages” means any loss, damage, claim or liability (joint or several) to which a party hereto may become subject under the
Securities Act, the Exchange Act, or other federal or state law, insofar as such loss, damage, claim or liability (or any action in respect thereof) arises out of or is based upon: (i) any untrue statement or alleged untrue statement of a
material fact contained in any registration statement of the Company, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto; (ii) an omission or alleged omission to state therein a
material fact required to be stated therein, or necessary to make the statements therein not misleading; or (iii) any violation or alleged violation by the indemnifying party (or any of its agents or Affiliates) of the Securities
Act, the Exchange Act, any state securities law, or any rule or regulation promulgated under the Securities Act, the Exchange Act, or any state securities law. 

“Derivative Securities” means any securities or rights convertible into, or exercisable or exchangeable for (in each case,
directly or indirectly), Common Stock, including options and warrants. 

  
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 “Exchange Act” means the Securities Exchange Act of 1934, as amended, and the
rules and regulations promulgated thereunder. 
 “Excluded Registration” means (i) a registration relating to the sale
of securities to employees of the Company or a subsidiary pursuant to a stock option, stock purchase, or similar plan; (ii) a registration relating to an SEC Rule 145 transaction; (iii) a registration on any form that does not include
substantially the same information as would be required to be included in a registration statement covering the sale of the Registrable Securities; or (iv) a registration in which the only Common Stock being registered is Common Stock issuable
upon conversion of debt securities that are also being registered. 
 “Fidelity Entity” means Fidelity or its Affiliated
Funds. 
 “Fidelity” means Fidelity Management & Research Company. 

“Form S-1” means such form under the Securities Act as in effect on the date
hereof or any successor registration form under the Securities Act subsequently adopted by the SEC. 
 “Form S-3” means such form under the Securities Act as in effect on the date hereof or any registration form under the Securities Act subsequently adopted by the SEC that permits incorporation of substantial
information by reference to other documents filed by the Company with the SEC. 
 “GAAP” means generally accepted
accounting principles in the United States. 
 “Holder” means any holder of Registrable Securities who is a party to this
Agreement. 
 “Immediate Family Member” means a child, stepchild, grandchild, parent, stepparent, grandparent, spouse,
sibling, mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law, or sister-in-law, including, adoptive relationships, of a natural person referred to herein. 

“Initiating Holders” means, collectively, Holders who properly initiate a registration request under this Agreement. 

“IPO” means the Company’s first underwritten public offering of its Common Stock under the Securities Act. 

“Key Employee” means any executive-level employee (including, division director and vice president-level positions) as well
as any employee who, either alone or in concert with others, develops, invents, programs, or designs any Company Intellectual Property (as defined in the Purchase Agreement). 

“Key Holder Registrable Securities” means (i) the shares of Common Stock held by the Key Holders, and (ii) any
Common Stock issued as (or issuable upon the conversion or exercise of any warrant, right, or other security that is issued as) a dividend or other distribution with respect to, or in exchange for or in replacement of such shares. 

  
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 “Major Investor” means (i) any Investor that, individually or together with
such Investor’s Affiliates, holds at least 1,000,000 shares of Registrable Securities (as adjusted for any stock split, stock dividend, combination, or other recapitalization or reclassification effected after the date hereof), and
(ii) with respect to Subsections 3.1 and 3.2, any Fidelity Entity for so long as such Fidelity Entity holds any shares of Registrable Securities. 

“New Securities” means, collectively, equity securities of the Company, whether or not currently authorized, as well as
rights, options, or warrants to purchase such equity securities, or securities of any type whatsoever that are, or may become, convertible or exchangeable into or exercisable for such equity securities. 

“Person” means any individual, corporation, partnership, trust, limited liability company, association or other entity. 

“Preferred Stock” means, collectively, shares of the Company’s Series A-1
Preferred Stock, Series A-2 Preferred Stock, Series A-3 Preferred Stock and Series B Preferred Stock. 

“Registrable Securities” means (i) the Common Stock issuable or issued upon conversion of the Preferred Stock;
(ii) any Common Stock, or any Common Stock issued or issuable (directly or indirectly) upon conversion and/or exercise of any other securities of the Company, acquired by the Investors after the date
hereof; (iii) the Key Holder Registrable Securities, provided, however, that such Key Holder Registrable Securities shall not be deemed Registrable Securities and the Key Holders shall not be deemed Holders for the purposes
of Subsections 2.1, 2.10, 3.1, 3.2, 4.1 and 6.6; and (iv) any Common Stock issued as (or issuable upon the conversion or exercise of any warrant, right, or other security that is issued as) a dividend or other
distribution with respect to, or in exchange for or in replacement of, the shares referenced in clauses (i) and (ii) above; excluding in all cases, however, any Registrable Securities sold by a Person in a transaction in which the
applicable rights under this Agreement are not assigned pursuant to Subsection 6.1, and excluding for purposes of Section 2 and Section 6.6 (with regard to consents to amendment and waiver) any shares for which registration
rights have terminated pursuant to Subsection 2.13 of this Agreement. 
 “Registrable Securities then
outstanding” means the number of shares determined by adding the number of shares of outstanding Common Stock that are Registrable Securities and the number of shares of Common Stock issuable (directly or indirectly) pursuant to then
exercisable and/or convertible securities that are Registrable Securities. 
 “Restricted Securities” means the securities
of the Company required to be notated with the legend set forth in Subsection 2.12(b) hereof. 
 “SEC” means
the Securities and Exchange Commission. 
 “SEC Rule 144” means Rule 144 promulgated by the SEC under the Securities Act.

  
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 “SEC Rule 145” means Rule 145 promulgated by the SEC under the Securities Act.

 “Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.

 “Selling Expenses” means all underwriting discounts, selling commissions, and stock transfer taxes applicable to the
sale of Registrable Securities, and fees and disbursements of counsel for any Holder, except for the fees and disbursements of the Selling Holder Counsel borne and paid by the Company as provided in Subsection 2.6. 

“Series A-1 Preferred Stock” means the shares of Series A-1 Preferred Stock, $0.0001 par value per share, of the Company. 
 “Series A-2 Preferred Stock” means the shares of Series A-2 Preferred Stock, $0.0001 par value per share, of the Company. 

“Series A-3 Director” means any director of the Company that the
holders of record of the Series A-3 Preferred Stock are entitled to elect pursuant to the Company’s Certificate of Incorporation. 

“Series A-3 Preferred Stock” means the shares of Series A-3 Preferred Stock, $0.0001 par value per share, of the Company. 
 “Series B Preferred
Stock” means the shares of Series B Preferred Stock, $0.0001 par value per share, of the Company. 
 2. Registration Rights.
The Company covenants and agrees as follows: 
 2.1 Demand Registration. 

(a) Form S-1 Demand. If at any time after the earlier of (i) three (3) years after the date of
this Agreement or (ii) one hundred eighty (180) days after the effective date of the registration statement for the IPO, the Company receives a request from Holders of at least fifty percent (50%) of the Registrable Securities then
outstanding that the Company file a Form S-1 registration statement with respect to at least fifty percent (50%) of the Registrable Securities then outstanding (or a lesser percent if the anticipated
aggregate offering price, net of Selling Expenses, would exceed $10 million), then the Company shall (x) within ten (10) days after the date such request is given, give notice thereof (the “Demand Notice”) to all Holders
other than the Initiating Holders; and (y) as soon as practicable file a Form S-1 registration statement under the Securities Act covering all Registrable Securities that the Initiating Holders
requested to be registered and any additional Registrable Securities requested to be included in such registration by any other Holders, as specified by notice given by each such Holder to the Company within twenty (20) days of the date
the Demand Notice is given, and in each case, subject to the limitations of Subsections 2.1(c) and 2.3. 

  
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 (b) Form S-3 Demand. If at any time when it is eligible
to use a Form S-3 registration statement, the Company receives a request from Holders of at least twenty percent (20%) of the Registrable Securities then outstanding that the Company file a Form S-3 registration statement with respect to outstanding Registrable Securities of such Holders having an anticipated aggregate offering price, net of Selling Expenses, of at least $5 million, then the Company
shall (i) within ten (10) days after the date such request is given, give a Demand Notice to all Holders other than the Initiating Holders; and (ii) as soon as practicable file a Form S-3
registration statement under the Securities Act covering all Registrable Securities requested to be included in such registration by any other Holders, as specified by notice given by each such Holder to the Company within twenty (20) days of
the date the Demand Notice is given, and in each case, subject to the limitations of Subsections 2.1(c) and 2.3. 
 (c) Notwithstanding the
foregoing obligations, if the Company furnishes to Holders requesting a registration pursuant to this Subsection 2.1 a certificate signed by the Company’s chief executive officer stating that in the good faith judgment of the
Company’s Board of Directors (the “Board”) it would be materially detrimental to the Company and its stockholders for such registration statement to either become effective or remain effective for as long as such registration
statement otherwise would be required to remain effective, because such action would (i) materially interfere with a significant acquisition, corporate reorganization, or other similar transaction involving the Company; (ii) require
premature disclosure of material information that the Company has a bona fide business purpose for preserving as confidential; or (iii) render the Company unable to comply with requirements under the Securities Act or Exchange Act, then the
Company shall have the right to defer taking action with respect to such filing, and any time periods with respect to filing or effectiveness thereof shall be tolled correspondingly, for a period of not more than sixty (60) days after the
request of the Initiating Holders is given; provided, however, that the Company may not invoke this right more than twice in any twelve (12) month period; and provided further that the Company shall not register any
securities for its own account or that of any other stockholder during such sixty (60) day period other than pursuant to a registration relating to the sale of securities to employees of the Company or a subsidiary pursuant to a stock option,
stock purchase, or similar plan; a registration on any form that does not include substantially the same information as would be required to be included in a registration statement covering the sale of the Registrable Securities; or a registration
in which the only Common Stock being registered is Common Stock issuable upon conversion of debt securities that are also being registered. 

(d) The Company shall not be obligated to effect, or to take any action to effect, any registration pursuant to Subsection
2.1(a)(i) during the period that is sixty (60) days before the Company’s good faith estimate of the date of filing of, and ending on a date that is one hundred eighty (180) days after the effective date of, a
Company-initiated registration, provided that the Company is actively employing in good faith commercially reasonable efforts to cause such registration statement to become effective; (ii) after the Company has effected two registrations
pursuant to Subsection 2.1(a); or (iii) if the Initiating Holders propose to dispose of shares of Registrable Securities that may be immediately registered on Form S-3 pursuant to a request made
pursuant to Subsection 2.1(b). The Company shall not be obligated to effect, or to take any action to effect, any registration pursuant to Subsection 2.1(b) (i) during the period that is thirty (30) days before the
Company’s good faith estimate of the date of filing of, and ending on a date that is ninety (90) days after the effective date of, a Company-initiated registration, provided that the Company is actively employing in good faith commercially
reasonable efforts to cause such registration statement to become effective; or (ii) if the Company has effected two 

  
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registrations pursuant to Subsection 2.1(b) within the twelve (12) month period immediately preceding the date of such request. A registration shall not be counted as
“effected” for purposes of this Subsection 2.1(d) until such time as the applicable registration statement has been declared effective by the SEC, unless the Initiating Holders withdraw their request for such registration,
elect not to pay the registration expenses therefor, and forfeit their right to one demand registration statement pursuant to Subsection 2.6, in which case such withdrawn registration statement shall be counted as “effected” for
purposes of this Subsection 2.1(d). 
 2.2 Company Registration. If the Company proposes to register (including, for this
purpose, a registration effected by the Company for stockholders other than the Holders) any of its securities under the Securities Act in connection with the public offering of such securities solely for cash (other than in an Excluded
Registration), the Company shall, at such time, promptly give each Holder notice of such registration. Upon the request of each Holder given within twenty (20) days after such notice is given by the Company, the Company shall, subject to the
provisions of Subsection 2.3, cause to be registered all of the Registrable Securities that each such Holder has requested to be included in such registration. The Company shall have the right to terminate or withdraw any registration
initiated by it under this Subsection 2.2 before the effective date of such registration, whether or not any Holder has elected to include Registrable Securities in such registration. The expenses (other than Selling Expenses) of such
withdrawn registration shall be borne by the Company in accordance with Subsection 2.6. 
 2.3 Underwriting Requirements. 

(a) If, pursuant to Subsection 2.1, the Initiating Holders intend to distribute the Registrable Securities covered by their
request by means of an underwriting, they shall so advise the Company as a part of their request made pursuant to Subsection 2.1, and the Company shall include such information in the Demand Notice. The underwriter(s) will be selected by the
Company and shall be reasonably acceptable to a majority in interest of the Initiating Holders. In such event, the right of any Holder to include such Holder’s Registrable Securities in such registration shall be conditioned upon such
Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their securities through such underwriting shall
(together with the Company as provided in Subsection 2.4(e)) enter into an underwriting agreement in customary form with the underwriter(s) selected for such underwriting. Notwithstanding any other provision of this Subsection 2.3, if
the managing underwriter(s) advise(s) the Initiating Holders in writing that marketing factors require a limitation on the number of shares to be underwritten, then the Initiating Holders shall so advise all Holders of Registrable Securities that
otherwise would be underwritten pursuant hereto, and the number of Registrable Securities that may be included in the underwriting shall be allocated among such Holders of Registrable Securities, including the Initiating Holders, in proportion (as
nearly as practicable) to the number of Registrable Securities owned by each Holder or in such other proportion as shall mutually be agreed to by all such selling Holders; provided, however, that the number of Registrable Securities
held by the Holders to be included in such underwriting shall not be reduced unless all other securities are first entirely excluded from the underwriting. To facilitate the allocation of shares in accordance with the above provisions, the Company
or the underwriters may round the number of shares allocated to any Holder to the nearest one hundred (100) shares. 

  
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 (b) In connection with any offering involving an underwriting of shares of the Company’s
capital stock pursuant to Subsection 2.2, the Company shall not be required to include any of the Holders’ Registrable Securities in such underwriting unless the Holders accept the terms of the underwriting as agreed upon between
the Company and its underwriters, and then only in such quantity, if any, as the underwriters in their sole discretion determine will not jeopardize the success of the offering by the Company. If the total number of securities, including Registrable
Securities, requested by stockholders to be included in such offering exceeds the number of securities to be sold (other than by the Company) that the underwriters in their reasonable discretion determine is compatible with the success of the
offering, then the Company shall be required to include in the offering only that number of such securities, including Registrable Securities, which the underwriters and the Company in their sole discretion determine will not jeopardize the success
of the offering. If the underwriters determine that less than all of the Registrable Securities requested to be registered can be included in such offering, then the Registrable Securities that are included in such offering shall be allocated among
the selling Holders in proportion (as nearly as practicable to) the number of Registrable Securities owned by each selling Holder or in such other proportions as shall mutually be agreed to by all such selling Holders. To facilitate the allocation
of shares in accordance with the above provisions, the Company or the underwriters may round the number of shares allocated to any Holder to the nearest one hundred (100) shares. Notwithstanding the foregoing, in no event shall (i) the
number of Registrable Securities included in the offering be reduced unless all other securities (other than securities to be sold by the Company) are first entirely excluded from the offering, or (ii) any Registrable Securities which are not
Key Holder Registrable Securities be excluded from such underwriting unless all Key Holder Registrable Securities are first excluded from such offering. For purposes of the provision in this Subsection 2.3(b) concerning apportionment, for any
selling Holder that is a partnership, limited liability company, or corporation, the partners, members, retired partners, retired members, stockholders, and Affiliates of such Holder, or the estates and Immediate Family Members of any such partners,
retired partners, members, and retired members and any trusts for the benefit of any of the foregoing Persons, shall be deemed to be a single “selling Holder,” and any pro rata reduction with respect to such “selling Holder”
shall be based upon the aggregate number of Registrable Securities owned by all Persons included in such “selling Holder,” as defined in this sentence. 

(c) For purposes of Subsection 2.1, a registration shall not be counted as “effected” if, as a result of an exercise of the
underwriter’s cutback provisions in Subsection 2.3(a), fewer than fifty percent (50%) of the total number of Registrable Securities that Holders have requested to be included in such registration statement are actually included. 

2.4 Obligations of the Company. Whenever required under this Section 2 to effect the registration of any
Registrable Securities, the Company shall, as expeditiously as reasonably possible: 
 (a) prepare and file with the SEC a registration
statement with respect to such Registrable Securities and use its commercially reasonable efforts to cause such registration statement to become effective and, upon the request of the Holders of a majority of the Registrable Securities registered
thereunder, keep such registration statement effective for a period of up to one hundred twenty (120) days or, if earlier, until the distribution contemplated in 

  
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the registration statement has been completed; provided, however, that (i) such one hundred twenty (120) day period shall be extended for a period of time equal to the
period the Holder refrains, at the request of an underwriter of Common Stock (or other securities) of the Company, from selling any securities included in such registration, and (ii) in the case of any registration of Registrable Securities on
Form S-3 that are intended to be offered on a continuous or delayed basis, subject to compliance with applicable SEC rules, such one hundred twenty (120) day period shall be extended for up to an
additional sixty (60) days, if necessary, to keep the registration statement effective until all such Registrable Securities are sold; 

(b) prepare and file with the SEC such amendments and supplements to such registration statement, and the prospectus used in connection with
such registration statement, as may be necessary to comply with the Securities Act in order to enable the disposition of all securities covered by such registration statement; 

(c) furnish to the selling Holders such numbers of copies of a prospectus, including a preliminary prospectus, as required by the Securities
Act, and such other documents as the Holders may reasonably request in order to facilitate their disposition of their Registrable Securities; 

(d) use its commercially reasonable efforts to register and qualify the securities covered by such registration statement under such other
securities or blue-sky laws of such jurisdictions as shall be reasonably requested by the selling Holders; provided that the Company shall not be required to qualify to do business or to file a general
consent to service of process in any such states or jurisdictions, unless the Company is already subject to service in such jurisdiction and except as may be required by the Securities Act; 

(e) in the event of any underwritten public offering, enter into and perform its obligations under an underwriting agreement, in usual and
customary form, with the underwriter(s) of such offering; 
 (f) use its commercially reasonable efforts to cause all such Registrable
Securities covered by such registration statement to be listed on a national securities exchange or trading system and each securities exchange and trading system (if any) on which similar securities issued by the Company are then listed; 

(g) provide a transfer agent and registrar for all Registrable Securities registered pursuant to this Agreement and provide a CUSIP number for
all such Registrable Securities, in each case not later than the effective date of such registration; 
 (h) promptly make available for
inspection by the selling Holders, any managing underwriter(s) participating in any disposition pursuant to such registration statement, and any attorney or accountant or other agent retained by any such underwriter or selected by the selling
Holders, all financial and other records, pertinent corporate documents, and properties of the Company, and cause the Company’s officers, directors, employees, and independent accountants to supply all information reasonably requested by any
such seller, underwriter, attorney, accountant, or agent, in each case, as necessary or advisable to verify the accuracy of the information in such registration statement and to conduct appropriate due diligence in connection therewith; 

  
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 (i) notify each selling Holder, promptly after the Company receives notice thereof, of the time
when such registration statement has been declared effective or a supplement to any prospectus forming a part of such registration statement has been filed; and 

(j) after such registration statement becomes effective, notify each selling Holder of any request by the SEC that the Company amend or
supplement such registration statement or prospectus. 
 In addition, the Company shall ensure that, at all times after any registration
statement covering a public offering of securities of the Company under the Securities Act shall have become effective, its insider trading policy shall provide that the Company’s directors may implement a trading program under Rule 10b5-1 of the Exchange Act. 
 2.5 Furnish Information. It shall be a condition precedent to the
obligations of the Company to take any action pursuant to this Section 2 with respect to the Registrable Securities of any selling Holder that such Holder shall furnish to the Company such information regarding itself, the
Registrable Securities held by it, and the intended method of disposition of such securities as is reasonably required to effect the registration of such Holder’s Registrable Securities. 

2.6 Expenses of Registration. All expenses (other than Selling Expenses) incurred in connection with registrations, filings, or
qualifications pursuant to Section 2, including all registration, filing, and qualification fees; printers’ and accounting fees; fees and disbursements of counsel for the Company; and the reasonable fees and
disbursements of one counsel for the selling Holders selected by the Holders of a majority of the Registrable Securities to be registered (“Selling Holder Counsel”), shall be borne and paid by the Company; provided,
that the Company shall not be required to pay for any expenses of any registration proceeding begun pursuant to Subsection 2.1 if the registration request is subsequently withdrawn at the request of the Holders of a majority of the
Registrable Securities to be registered (in which case all selling Holders shall bear such expenses pro rata based upon the number of Registrable Securities that were to be included in the withdrawn registration), unless the Holders of a majority of
the Registrable Securities agree to forfeit their right to one registration pursuant to Subsections 2.1(a) or 2.1(b), as the case may be; provided further that if, at the time of such withdrawal, the Holders shall
have learned of a material adverse change in the condition, business, or prospects of the Company from that known to the Holders at the time of their request and have withdrawn the request with reasonable promptness after learning of such
information then the Holders shall not be required to pay any of such expenses and shall not forfeit their right to one registration pursuant to Subsections 2.1(a) or 2.1(b). All Selling Expenses relating to Registrable Securities
registered pursuant to this Section 2 shall be borne and paid by the Holders pro rata on the basis of the number of Registrable Securities registered on their behalf. 

2.7 Delay of Registration. No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any
registration pursuant to this Agreement as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 

  
 10 

 2.8 Indemnification. If any Registrable Securities are included in a registration
statement under this Section 2: 
 (a) To the extent permitted by law, the Company will indemnify and hold
harmless each selling Holder, and the partners, members, officers, directors, and stockholders of each such Holder; legal counsel and accountants for each such Holder; any underwriter (as defined in the Securities Act) for each such Holder; and each
Person, if any, who controls such Holder or underwriter within the meaning of the Securities Act or the Exchange Act, against any Damages, and the Company will pay to each such Holder, underwriter, controlling Person, or other aforementioned Person
any legal or other expenses reasonably incurred thereby in connection with investigating or defending any claim or proceeding from which Damages may result, as such expenses are incurred; provided, however, that the indemnity agreement
contained in this Subsection 2.8(a) shall not apply to amounts paid in settlement of any such claim or proceeding if such settlement is effected without the consent of the Company, which consent shall not be unreasonably withheld, nor
shall the Company be liable for any Damages to the extent that they arise out of or are based upon actions or omissions made in reliance upon and in conformity with written information furnished by or on behalf of any such Holder, underwriter,
controlling Person, or other aforementioned Person expressly for use in connection with such registration. 
 (b) To the extent permitted by
law, each selling Holder, severally and not jointly, will indemnify and hold harmless the Company, and each of its directors, each of its officers who has signed the registration statement, each Person (if any), who controls the Company within the
meaning of the Securities Act, legal counsel and accountants for the Company, any underwriter (as defined in the Securities Act), any other Holder selling securities in such registration statement, and any controlling Person of any such underwriter
or other Holder, against any Damages, in each case only to the extent that such Damages arise out of or are based upon actions or omissions made in reliance upon and in conformity with written information furnished by or on behalf of such selling
Holder expressly for use in connection with such registration; and each such selling Holder will pay to the Company and each other aforementioned Person any legal or other expenses reasonably incurred thereby in connection with investigating or
defending any claim or proceeding from which Damages may result, as such expenses are incurred; provided, however, that the indemnity agreement contained in this Subsection 2.8(b) shall not apply to amounts paid in
settlement of any such claim or proceeding if such settlement is effected without the consent of the Holder, which consent shall not be unreasonably withheld; and provided further that in no event shall the aggregate amounts payable by
any Holder by way of indemnity or contribution under Subsections 2.8(b) and 2.8(d) exceed the proceeds from the offering received by such Holder (net of any Selling Expenses paid by such Holder), except in the case of fraud or willful
misconduct by such Holder. 
 (c) Promptly after receipt by an indemnified party under this Subsection 2.8 of notice of the
commencement of any action (including any governmental action) for which a party may be entitled to indemnification hereunder, such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this

  
 11 

 
Subsection 2.8, give the indemnifying party notice of the commencement thereof. The indemnifying party shall have the right to participate in such action and, to the extent the
indemnifying party so desires, participate jointly with any other indemnifying party to which notice has been given, and to assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an
indemnified party (together with all other indemnified parties that may be represented without conflict by one counsel) shall have the right to retain one separate counsel, with the fees and expenses to be paid by the indemnifying party, if
representation of such indemnified party by the counsel retained by the indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any other party represented by such counsel in such
action. The failure to give notice to the indemnifying party within a reasonable time of the commencement of any such action shall relieve such indemnifying party of any liability to the indemnified party under this Subsection 2.8, to the
extent that such failure materially prejudices the indemnifying party’s ability to defend such action. The failure to give notice to the indemnifying party will not relieve it of any liability that it may have to any indemnified party otherwise
than under this Subsection 2.8. 
 (d) To provide for just and equitable contribution to joint liability under the Securities Act in
any case in which either: (i) any party otherwise entitled to indemnification hereunder makes a claim for indemnification pursuant to this Subsection 2.8 but it is judicially determined (by the entry of a final judgment or decree by a
court of competent jurisdiction and the expiration of time to appeal or the denial of the last right of appeal) that such indemnification may not be enforced in such case, notwithstanding the fact that this Subsection 2.8 provides for
indemnification in such case, or (ii) contribution under the Securities Act may be required on the part of any party hereto for which indemnification is provided under this Subsection 2.8, then, and in each such case, such parties will
contribute to the aggregate losses, claims, damages, liabilities, or expenses to which they may be subject (after contribution from others) in such proportion as is appropriate to reflect the relative fault of each of the indemnifying party and the
indemnified party in connection with the statements, omissions, or other actions that resulted in such loss, claim, damage, liability, or expense, as well as to reflect any other relevant equitable considerations. The relative fault of the
indemnifying party and of the indemnified party shall be determined by reference to, among other things, whether the untrue or allegedly untrue statement of a material fact, or the omission or alleged omission of a material fact, relates to
information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information, and opportunity to correct or prevent such statement or omission; provided, however,
that, in any such case (x) no Holder will be required to contribute any amount in excess of the public offering price of all such Registrable Securities offered and sold by such Holder pursuant to such registration statement, and (y) no
Person guilty of fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) will be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation; and provided
further that in no event shall a Holder’s liability pursuant to this Subsection 2.8(d), when combined with the amounts paid or payable by such Holder pursuant to Subsection 2.8(b), exceed the proceeds from the offering
received by such Holder (net of any Selling Expenses paid by such Holder), except in the case of willful misconduct or fraud by such Holder. 

  
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 (e) Notwithstanding the foregoing, to the extent that the provisions on indemnification and
contribution contained in the underwriting agreement entered into in connection with the underwritten public offering are in conflict with the foregoing provisions, the provisions in the underwriting agreement shall control. 

(f) Unless otherwise superseded by an underwriting agreement entered into in connection with the underwritten public offering, the obligations
of the Company and Holders under this Subsection 2.8 shall survive the completion of any offering of Registrable Securities in a registration under this Section 2, and otherwise shall survive the termination of this
Agreement. 
 2.9 Reports Under Exchange Act. With a view to making available to the Holders the benefits of SEC Rule 144 and any
other rule or regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the public without registration or pursuant to a registration on Form S-3, the Company shall: 

(a) make and keep available adequate current public information, as those terms are understood and defined in SEC Rule 144, at all times after
the effective date of the registration statement filed by the Company for the IPO; 
 (b) use commercially reasonable efforts to file with
the SEC in a timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act (at any time after the Company has become subject to such reporting requirements); and 

(c) furnish to any Holder, so long as the Holder owns any Registrable Securities, forthwith upon request (i) to the extent accurate, a
written statement by the Company that it has complied with the reporting requirements of SEC Rule 144 (at any time after ninety (90) days after the effective date of the registration statement filed by the Company for the IPO), the Securities
Act, and the Exchange Act (at any time after the Company has become subject to such reporting requirements), or that it qualifies as a registrant whose securities may be resold pursuant to Form S-3 (at any
time after the Company so qualifies); and (ii) such other information as may be reasonably requested in availing any Holder of any rule or regulation of the SEC that permits the selling of any such securities without registration (at any time
after the Company has become subject to the reporting requirements under the Exchange Act) or pursuant to Form S-3 (at any time after the Company so qualifies to use such form). 

2.10 Limitations on Subsequent Registration Rights. From and after the date of this Agreement, the Company shall not, without the prior
written consent of the Holders of a majority of the Registrable Securities then outstanding, enter into any agreement with any holder or prospective holder of any securities of the Company that would allow such holder or prospective holder
(i) to include such securities in any registration unless, under the terms of such agreement, such holder or prospective holder may include such securities in any such registration only to the extent that the inclusion of such securities will
not reduce the number of the Registrable Securities of the Holders that are included; or (ii) allow such holder or prospective holder to initiate a demand for registration of any securities held by such holder or prospective holder;
provided that this limitation shall not apply to any additional Investor who becomes a party to this Agreement in accordance with Subsection 6.9. 

  
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 2.11 “Market
Stand-off” Agreement. 
 (a) Each Holder hereby agrees that it will
not, without the prior written consent of the managing underwriter, during the period commencing on the date of the final prospectus relating to the registration by the Company of shares of its Common Stock or any other equity securities under the
Securities Act on a registration statement on Form S-1, and ending on the date specified by the Company and the managing underwriter (such period not to exceed one hundred eighty (180) days in the case of the IPO, or such other period as
may be required by applicable law to accommodate regulatory restrictions on (1) the publication or other distribution of research reports, and (2) analyst recommendations and opinions, including, but not limited to, the restrictions
contained in FINRA Rule 2711(f)(4) or NYSE Rule 472(f)(4), or any successor provisions or amendments thereto), (i) lend; offer; pledge; sell; contract to sell; sell any option or contract to purchase; purchase any option or contract to sell; grant
any option, right, or warrant to purchase; or otherwise transfer or dispose of, directly or indirectly, any shares of Common Stock or any securities convertible into or exercisable or exchangeable (directly or indirectly) for Common Stock held
immediately before the effective date of the registration statement for such offering or (ii) enter into any swap or other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership
of such securities, whether any such transaction described in clause (i) or (ii) above is to be settled by delivery of Common Stock or other securities, in cash, or otherwise. 

(b) The foregoing provisions of this Subsection 2.11 shall apply only to the IPO, shall not apply to (i) the sale of any
shares to an underwriter pursuant to an underwriting agreement, or (ii) the transfer of any shares by a Holder to an Affiliate of such Holder or the transfer of any shares to any trust for the direct or indirect benefit of the Holder or the
immediate family of the Holder, provided that the trustee of the trust agrees to be bound in writing by the restrictions set forth herein, and provided further that any such transfer shall not involve a disposition for value,
and shall be applicable to the Holders only if all officers, directors and stockholders individually owning more than one percent (1%) of the Company’s outstanding Common Stock (after giving effect to conversion into Common Stock of all
outstanding Preferred Stock) are subject to the same restrictions. 
 (c) The underwriters in connection with such registration are intended
third-party beneficiaries of this Subsection 2.11 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. Each Holder further agrees to execute
such agreements as may be reasonably requested by the underwriters in connection with such registration that are consistent with this Subsection 2.11 or that are necessary to give further effect thereto. 

(d) Subject to customary exceptions and share holding thresholds, any discretionary waiver or termination of the restrictions of any or all of
such agreements by the Company or the underwriters shall apply pro rata to all Holders subject to such agreements, based on the number of shares subject to such agreements. 

  
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 2.12 Restrictions on Transfer. 

(a) The Preferred Stock and the Registrable Securities shall not be sold, pledged, or otherwise transferred, and the Company shall not
recognize and shall issue stop-transfer instructions to its transfer agent with respect to any such sale, pledge, or transfer, except upon the conditions specified in this Agreement, which conditions are intended to ensure compliance with the
provisions of the Securities Act. A transferring Holder will cause any proposed purchaser, pledgee, or transferee of the Preferred Stock and the Registrable Securities held by such Holder to agree to take and hold such securities subject to the
provisions and upon the conditions specified in this Agreement. 
 (b) Each certificate, instrument, or book entry representing (i) the
Preferred Stock, (ii) the Registrable Securities, and (iii) any other securities issued in respect of the securities referenced in clauses (i) and (ii), upon any stock split, stock dividend, recapitalization, merger, consolidation, or
similar event, shall (unless otherwise permitted by the provisions of Subsection 2.12(c)) be notated with a legend substantially in the following form: 

THE SECURITIES REPRESENTED HEREBY HAVE BEEN ACQUIRED FOR INVESTMENT AND HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF
1933, AS AMENDED. SUCH SHARES MAY NOT BE SOLD, PLEDGED, OR TRANSFERRED IN THE ABSENCE OF SUCH REGISTRATION OR A VALID EXEMPTION FROM THE REGISTRATION AND PROSPECTUS DELIVERY REQUIREMENTS OF SAID ACT. 

THE SECURITIES REPRESENTED HEREBY MAY BE TRANSFERRED ONLY IN ACCORDANCE WITH THE TERMS OF AN AGREEMENT BETWEEN THE COMPANY AND
THE STOCKHOLDER, A COPY OF WHICH IS ON FILE WITH THE SECRETARY OF THE COMPANY. 
 The Holders consent to the Company making a notation in
its records and giving instructions to any transfer agent of the Restricted Securities in order to implement the restrictions on transfer set forth in this Subsection 2.12. 

(c) The holder of such Restricted Securities, by acceptance of ownership thereof, agrees to comply in all respects with the provisions of this
Section 2. Before any proposed sale, pledge, or transfer of any Restricted Securities, unless there is in effect a registration statement under the Securities Act covering the proposed transaction, the Holder thereof shall
give notice to the Company of such Holder’s intention to effect such sale, pledge, or transfer. Each such notice shall describe the manner and circumstances of the proposed sale, pledge, or transfer in sufficient detail and, if reasonably
requested by the Company, shall be accompanied at such Holder’s expense by either (i) a written opinion of legal counsel who shall, and whose legal opinion shall, be reasonably satisfactory to the Company, addressed to the Company, to the
effect that the proposed transaction may be effected without registration under the Securities Act; (ii) a “no action” letter from the SEC to the effect that the proposed sale, pledge, or transfer of such Restricted Securities without
registration will not result in a recommendation by the staff of the SEC that action be taken with respect thereto; or (iii) any other evidence reasonably satisfactory to counsel to the Company to the effect that the proposed

  
 15 

 
sale, pledge, or transfer of the Restricted Securities may be effected without registration under the Securities Act, whereupon the Holder of such Restricted Securities shall be entitled to sell,
pledge, or transfer such Restricted Securities in accordance with the terms of the notice given by the Holder to the Company. The Company will not require such a legal opinion or “no action” letter (x) in any transaction in compliance
with SEC Rule 144; or (y) in any transaction in which such Holder distributes Restricted Securities to an Affiliate of such Holder or the Holder transfers Restricted Securities to an Affiliated Fund, or (z) in any transaction in which such
Holder transfers Restricted Securities by gift, will or intestate succession to his or her Immediate Family Member or trust for the benefit of an individual Holder or one or more of such Holder’s Immediate Family Members; provided that
each transferee agrees in writing to be subject to the terms of this Subsection 2.12. Each certificate, instrument, or book entry representing the Restricted Securities transferred as above provided shall be notated with, except if such
transfer is made pursuant to SEC Rule 144, the appropriate restrictive legend set forth in Subsection 2.12(b), except that such certificate instrument, or book entry shall not be notated with such restrictive legend if, in the opinion of
counsel for such Holder and the Company, such legend is not required in order to establish compliance with any provisions of the Securities Act. 

2.13 Termination of Registration Rights. The right of any Holder to request registration or inclusion of Registrable Securities in any
registration pursuant to Subsections 2.1 or 2.1(d) shall terminate upon the earliest to occur of: 
 (a) the closing of a
Deemed Liquidation Event, as such term is defined in the Company’s Certificate of Incorporation (as may be amended from time to time); 

(b) such time as Rule 144 or another similar exemption under the Securities Act is available for the sale of all of such Holder’s
shares without limitation during a three-month period without registration; and 
 (c) the fifth anniversary of the IPO. 

3. Information and Observer Rights. 

3.1 Delivery of Financial Statements. The Company shall deliver to each Major Investor, provided that the Board has not
reasonably determined that such Major Investor is a Competitor: 
 (a) as soon as practicable, but in any event within one hundred twenty
(120) days after the end of each fiscal year of the Company (i) a balance sheet as of the end of such year, (ii) statements of income and of cash flows for such year, and a comparison between (x) the actual amounts as of and for
such fiscal year and (y) the comparable amounts for the prior year and as included in the Budget (as defined in Subsection 3.1(e)) for such year, with an explanation of any material differences between such amounts and a schedule as to
the sources and applications of funds for such year, and (iii) a statement of stockholders’ equity as of the end of such year, all such financial statements audited and certified by independent public accountants of recognized standing
selected by the Board; 

  
 16 

 (b) as soon as practicable, but in any event within
forty-five (45) days after the end of each of the first three (3) quarters of each fiscal year of the Company, unaudited statements of income and cash flows for such fiscal quarter, and an unaudited
balance sheet and a statement of stockholders’ equity as of the end of such fiscal quarter, all prepared in accordance with GAAP (except that such financial statements may (i) be subject to normal
year-end audit adjustments; and (ii) not contain all notes thereto that may be required in accordance with GAAP); 

(c) as soon as practicable, but in any event within forty-five (45) days after the end of each of the first three (3) quarters of
each fiscal year of the Company, a statement showing the number of shares of each class and series of capital stock and securities convertible into or exercisable for shares of capital stock outstanding at the end of the period, the Common Stock
issuable upon conversion or exercise of any outstanding securities convertible or exercisable for Common Stock and the exchange ratio or exercise price applicable thereto, and the number of shares of issued stock options and stock options not yet
issued but reserved for issuance, if any, all in sufficient detail as to permit the Major Investors to calculate their respective percentage equity ownership in the Company, and certified by the chief financial officer or chief executive officer of
the Company as being true, complete, and correct; 
 (d) as soon as practicable, but in any event within thirty (30) days of the end of
each month, an unaudited income statement and statement of cash flows for such month, and an unaudited balance sheet and statement of stockholders’ equity as of the end of such month, all prepared in accordance with GAAP (except that such
financial statements may (i) be subject to normal year-end audit adjustments and (ii) not contain all notes thereto that may be required in accordance with GAAP); 

(e) as soon as practicable, but in any event thirty (30) days before the end of each fiscal year, a budget and business plan for the next
fiscal year (collectively, the “Budget”), approved by the Board and prepared on a monthly basis, including balance sheets, income statements, and statements of cash flow for such months and, promptly after prepared, any other
budgets or revised budgets prepared by the Company; 
 (f) with respect to the financial statements called for in Subsection 3.1(a),
Subsection 3.1(b) and Subsection 3.1(d), an instrument executed by the chief financial officer of the Company certifying that such financial statements were prepared in accordance with GAAP consistently applied with prior practice for
earlier periods (except as otherwise set forth in Subsection 3.1(b) and Subsection 3.1(d)) and fairly present the financial condition of the Company and its results of operation for the periods specified therein; and 

(g) such other information relating to the financial condition, business, prospects, or corporate affairs of the Company as any Major Investor
may from time to time reasonably request; provided, however, that the Company shall not be obligated under this Subsection 3.1 to provide information (i) that the Company reasonably determines in good faith to be a trade
secret or confidential information (unless covered by an enforceable confidentiality agreement, in a form acceptable to the Company); or (ii) the disclosure of which would adversely affect the attorney-client privilege between the Company and
its counsel. 
 If, for any period, the Company has any subsidiary whose accounts are consolidated with those of the Company, then in respect
of such period the financial statements delivered pursuant to the foregoing sections shall be the consolidated and consolidating financial statements of the Company and all such consolidated subsidiaries. 

  
 17 

 Notwithstanding anything else in this Subsection 3.1 to the contrary, the Company may
cease providing the information set forth in this Subsection 3.1 during the period starting with the date thirty (30) days before the Company’s good-faith estimate of the date of filing of a registration statement if it reasonably
concludes it must do so to comply with the SEC rules applicable to such registration statement and related offering; provided that the Company’s covenants under this Subsection 3.1 shall be reinstated at such time as the Company
is no longer actively employing its commercially reasonable efforts to cause such registration statement to become effective. 
 3.2
Inspection. The Company shall permit each Major Investor (provided that the Board has not reasonably determined that such Major Investor is a Competitor of the Company), at such Major Investor’s expense, to visit and inspect the
Company’s properties; examine its books of account and records; and discuss the Company’s affairs, finances, and accounts with its officers, during normal business hours of the Company as may be reasonably requested by the Major Investor;
provided, however, that the Company shall not be obligated pursuant to this Subsection 3.2 to provide access to any information that it reasonably and in good faith considers to be a trade secret or confidential information
(unless covered by an enforceable confidentiality agreement, in form acceptable to the Company) or the disclosure of which would adversely affect the attorney-client privilege between the Company and its counsel. 

3.3 Observer Rights. As long as ARCH Venture Fund VIII, L.P. (“ARCH”) owns not less than twenty percent (20%) of the
shares of the Preferred Stock it owns as of the date hereof (or an equivalent amount of Common Stock issued upon conversion thereof) and does not have two (2) Affiliates then serving on the Board of Directors, the Company shall invite a
representative of ARCH to attend all meetings of its Board of Directors in a nonvoting observer capacity and, in this respect, shall give such representative copies of all notices, minutes, consents, and other materials that it provides to its
directors at the same time and in the same manner as provided to such directors; provided, that such representative shall agree to hold in confidence and trust and to act in a fiduciary manner with respect to all information so provided; and
provided further, that the Company reserves the right to withhold any information and to exclude such representative from any meeting or portion thereof if access to such information or attendance at such meeting could adversely affect
the attorney-client privilege between the Company and its counsel or result in disclosure of trade secrets or a conflict of interest, or if such Investor or its representative is a Competitor of the Company. 

3.4 Termination of Information and Observer Rights. The covenants set forth in Subsection 3.1, Subsection 3.2, and
Subsection 3.3 shall terminate and be of no further force or effect (i) immediately before the consummation of the IPO, or (ii) when the Company first becomes subject to the periodic reporting requirements of
Section 12(g) or 15(d) of the Exchange Act, whichever event occurs first. 

  
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 3.5 Confidentiality. Each Investor agrees that such Investor will keep confidential and
will not disclose, divulge, or use for any purpose (other than to monitor its investment in the Company) any confidential information obtained from the Company pursuant to the terms of this Agreement (including notice of the Company’s intention
to file a registration statement), unless such confidential information (a) is known or becomes known to the public in general (other than as a result of a breach of this Subsection 3.5 by such Investor), (b) is or has been independently
developed or conceived by the Investor without use of the Company’s confidential information, or (c) is or has been made known or disclosed to the Investor by a third party without a breach of any obligation of confidentiality such third
party may have to the Company; provided, that an Investor may disclose confidential information (i) to its attorneys, accountants, consultants, and other professionals to the extent necessary to obtain their services in connection with
monitoring its investment in the Company; (ii) to any prospective purchaser of any Registrable Securities from such Investor, if such prospective purchaser agrees to be bound by the provisions of this Subsection 3.5; (iii) to any
existing or prospective Affiliate, Affiliated Fund, partner, member, stockholder, or wholly owned subsidiary of such Investor in the ordinary course of business, provided that such Investor informs such Person that such information is confidential
and directs such Person to maintain the confidentiality of such information; (iv) as may otherwise be required by law, provided that the Investor promptly notifies the Company of such disclosure and takes reasonable steps to minimize the
extent of any such required disclosure; or (v) in the case of any Investor that is a registered investment company within the meaning of the Investment Company Act of 1940, as amended, consistent with investment reporting practices. For
avoidance of doubt, nothing contained in this Section 3.5 shall in any way restrict or impair the obligations of Fidelity to report the investment of its advisory clients (as Investors hereunder) in the Company in accordance with applicable
laws and regulations, without any requirement of prior notice to the Company. 
 3.6 “Bad Actor”
Covenant. In the event the Company proposes an offering of its securities in reliance on Rule 506 of the Securities Act, the Company intends to conduct an inquiry of all Investors and Key Holders that beneficially own 20% or more of the
Company’s then outstanding voting equity securities, calculated on the basis of voting power (each, a “20% Holder”), as to whether any 20% Holder or any Rule 506(d) Related Party of such 20% Holder is a “bad actor”
within the meaning of Rule 506(d) promulgated under the Securities Act (each, a “Bad Actor”). Each Stockholder (other than any Fidelity Entity) hereby agrees that it shall provide information reasonably requested by the Company in
order to conduct its inquiry within five (5) business days after the date of the Company’s request therefor. For purposes of this Agreement, “Rule 506(d) Related Party” means a person or entity covered by the “Bad
Actor disqualification” provision of Rule 506(d) of the Securities Act. 
 4. Rights to Future Stock Issuances. 

4.1 Right of First Offer. Subject to the terms and conditions of this Subsection 4.1 and applicable securities laws, if the
Company proposes to offer or sell any New Securities, the Company shall first offer such New Securities to each Major Investor. A Major Investor shall be entitled to apportion the right of first offer hereby granted to it in such proportions as it
deems appropriate, among (i) itself, (ii) its Affiliates and (iii) its beneficial interest holders, such as limited partners, members or any other Person having “beneficial ownership,” as such term is defined in Rule 13d-3 promulgated under the Exchange Act, of such Major Investor (“Investor Beneficial Owners”); provided that each such Affiliate or Investor Beneficial Owner (x) is not a
Competitor, unless such party’s purchase of New Securities is otherwise consented to by the Board of Directors, and (y) agrees to enter into this Agreement and each of the Voting 

  
 19 

 
Agreement and Right of First Refusal and Co-Sale Agreement of even date herewith among the Company, the Investors and the other parties named therein, as
an “Investor” under each such agreement (provided that any Competitor shall not be entitled to any rights as a Major Investor under Subsections 3.1, 3.2 and 4.1 hereof). 

(a) The Company shall give notice (the “Offer Notice”) to each Major Investor, stating (i) its bona fide intention to
offer such New Securities, (ii) the number of such New Securities to be offered, and (iii) the price and terms, if any, upon which it proposes to offer such New Securities. 

(b) By notification to the Company within twenty (20) days after the Offer Notice is given, each Major Investor may elect to purchase or
otherwise acquire, at the price and on the terms specified in the Offer Notice, up to that portion of such New Securities which equals the proportion that the Common Stock then held by such Major Investor (including all shares of Common Stock then
issuable (directly or indirectly) upon conversion and/or exercise, as applicable, of the Preferred Stock and any other Derivative Securities then held by such Major Investor) bears to the total Common Stock of the Company then outstanding (assuming
full conversion and/or exercise, as applicable, of all Preferred Stock and other Derivative Securities). At the expiration of such twenty (20) day period, the Company shall promptly notify each Major Investor that elects to purchase or acquire
all the shares available to it (each, a “Fully Exercising Investor”) of any other Major Investor’s failure to do likewise. During the ten (10) day period commencing after the Company has given such notice, each Fully
Exercising Investor may, by giving notice to the Company, elect to purchase or acquire, in addition to the number of shares specified above, up to that portion of the New Securities for which Major Investors were entitled to subscribe but that were
not subscribed for by the Major Investors which is equal to the proportion that the Common Stock issued and held, or issuable (directly or indirectly) upon conversion and/or exercise, as applicable, of Preferred Stock and any other Derivative
Securities then held, by such Fully Exercising Investor bears to the Common Stock issued and held, or issuable (directly or indirectly) upon conversion and/or exercise, as applicable, of the Preferred Stock and any other Derivative Securities
then held, by all Fully Exercising Investors who wish to purchase such unsubscribed shares. The closing of any sale pursuant to this Subsection 4.1(b) shall occur within the later of ninety (90) days of the date that the Offer Notice
is given and the date of initial sale of New Securities pursuant to Subsection 4.1(b). 
 (c) If all New Securities referred to in the Offer
Notice are not elected to be purchased or acquired as provided in Subsection 4.1(b), the Company may, during the ninety (90) day period following the expiration of the periods provided in Subsection 4.1(b), offer and sell the
remaining unsubscribed portion of such New Securities to any Person or Persons at a price not less than, and upon terms no more favorable to the offeree than, those specified in the Offer Notice. If the Company does not enter into an agreement for
the sale of the New Securities within such period, or if such agreement is not consummated within thirty (30) days of the execution thereof, the right provided hereunder shall be deemed to be revived and such New Securities shall not be offered
unless first reoffered to the Major Investors in accordance with this Subsection 4.1. 

  
 20 

 (d) The right of first offer in this Subsection 4.1 shall not be applicable to
(i) Exempted Securities (as defined in the Company’s Certificate of Incorporation (as may be amended from time to time)); (ii) shares of Series B Preferred Stock issued pursuant to the Purchase Agreement; and (iii) shares of Common
Stock issued in the IPO. 
 4.2 Termination. The covenants set forth in Subsection 4.1 shall terminate and be of no further
force or effect (i) immediately before the consummation of the IPO, (ii) when the Company first becomes subject to the periodic reporting requirements of Section 12(g) or 15(d) of the Exchange Act, or (iii) upon a Deemed
Liquidation Event, as such term is defined in the Company’s Certificate of Incorporation (as may be amended from time to time), whichever event occurs first. 

5. Additional Covenants. 

5.1 Insurance. The Company shall use its commercially reasonable efforts (i) to cause to be maintained a directors and officers
liability insurance (the “D&O Policy”) and (ii) to obtain, as soon as reasonably practicable after the date hereof, and cause to be maintained term “key person” insurance on Frederick C. Beddingfield III (the
“Key Person Policy” and together with the D&O Policy, the “Policies”) from financially sound and reputable insurers, each in an amount and on terms and conditions satisfactory to the Board of Directors, until
such time as the Board of Directors determines that such Policies should be discontinued. The Key Person Policy shall name the Company as loss payee, and neither of the Policies shall be cancelable by the Company without prior approval by the Board
of Directors including at least one Series A-3 Director and holders of a majority of the Preferred Stock. Notwithstanding any other provision of this Section 5.1 to the contrary, for
so long as at least one Series A-3 Director is serving on the Board of Directors, the Company shall not cease to maintain a D&O Policy in an amount of at least $3 million unless approved by the Board
of Directors and at least one Series A-3 Director, and the Company shall annually, within one hundred twenty (120) days after the end of each fiscal year of the Company, deliver to the Investors a
certification that such a D&O Policy remains in effect. 
 5.2 Employee Agreements. The Company will cause (i) each person
now or hereafter employed by it or by any subsidiary (or engaged by the Company or any subsidiary as a consultant/independent contractor) with access to confidential information and/or trade secrets to enter into a nondisclosure and proprietary
rights assignment agreement; and (ii) each Key Employee to enter into a one (1) year nonsolicitation agreement, substantially in the form approved by the Board of Directors. In addition, the Company shall not amend, modify, terminate,
waive, or otherwise alter, in whole or in part, any of the above-referenced agreements or any restricted stock agreement between the Company and any employee, without the consent of the Board of Directors, including at least one Series A-3 Director. 
 5.3 Employee Stock. Unless otherwise approved by the Board of Directors,
including at least one Series A-3 Director, all future employees and consultants of the Company who purchase, receive options to purchase, or receive awards of shares of the Company’s capital stock after
the date hereof shall be required to execute restricted stock or option agreements, as applicable, providing for (i) vesting of shares over a four (4) year period, with the first twenty-five percent (25%) of such shares vesting following
twelve (12) months of continued 

  
 21 

 
employment or service, and the remaining shares vesting in equal monthly installments over the following thirty-six (36) months, and (ii) a
market stand-off provision substantially similar to that in Subsection 2.11. In addition, unless otherwise approved by the Board of Directors, the Company shall retain a “right of first
refusal” on employee transfers until the Company’s IPO and shall have the right to repurchase unvested shares at cost upon termination of employment of a holder of restricted stock. 

5.4 Matters Requiring Investor Director Approval. So long as the holders of Series A-3 Preferred
Stock are entitled to elect a Series A-3 Director, the Company hereby covenants and agrees with each of the Investors that it shall not, nor shall it permit any subsidiary to, without approval of the Board of
Directors, which approval must include the affirmative vote of at least one Series A-3 Director: 

(a) make any loan or advance to, or own any stock or other securities of, any subsidiary or other corporation, partnership, or other entity
unless it is wholly owned by the Company; 
 (b) make any loan or advance to any Person, including, without limitation, any employee or
director of the Company or any subsidiary, except advances and similar expenditures in the ordinary course of business or under the terms of an employee stock or option plan approved by the Board of Directors; 

(c) guarantee, directly or indirectly any indebtedness except for trade accounts of the Company or any subsidiary arising in the ordinary
course of business; 
 (d) make any investment inconsistent with any investment policy approved by the Board of Directors; 

(e) incur any aggregate indebtedness in excess of $500,000 that is not already included in a budget approved by the Board of Directors, other
than trade credit incurred in the ordinary course of business; 
 (f) otherwise enter into or be a party to any transaction with any
director, officer, or employee of the Company or any “associate” (as defined in Rule 12b-2 promulgated under the Exchange Act) of any such Person, except for transactions contemplated by this
Agreement and the Purchase Agreement; or transactions made in the ordinary course of business and pursuant to reasonable requirements of the Company’s business and upon fair and reasonable terms that are approved by a majority of the Board of
Directors, including at least one Series A-3 Director; 
 (g) hire, terminate, or change the
compensation of the executive officers, including approving any option grants or stock awards to executive officers; 
 (h) change the
principal business of the Company, enter new lines of business, or exit the current line of business; 
 (i) sell, assign, license, pledge,
or encumber material technology or intellectual property, other than licenses granted in the ordinary course of business; 

  
 22 

 (j) increase the shares of Common Stock reserved for issuance under the Company’s 2010
Equity Incentive Plan or adopt any other equity incentive plan; or 
 (k) enter into any corporate strategic relationship involving the
payment, contribution, or assignment by the Company or to the Company of money or assets greater than $500,000. 
 5.5 Board Matters.
Unless otherwise determined by the vote of a majority of the directors then in office, the Board of Directors shall meet at least quarterly in accordance with an agreed-upon schedule. The Company shall reimburse the directors for all reasonable out-of-pocket travel expenses incurred (consistent with the Company’s travel policy) in connection with attending meetings of the Board of Directors. The Company shall
cause to be established, as soon as practicable after such request, and will maintain, an audit committee and a compensation committee, each of which shall consist solely of non-management directors. So long
as the holders of Series A-3 Preferred Stock are entitled to elect at least one (1) Series A-3 Director, each committee of the Board shall include at least one
Series A-3 Director. 
 5.6 Successor Indemnification. If the Company or any of its successors
or assignees consolidates with or merges into any other Person and is not the continuing or surviving corporation or entity of such consolidation or merger, then to the extent necessary, proper provision shall be made so that the successors and
assignees of the Company assume the obligations of the Company with respect to indemnification of members of the Board of Directors as in effect immediately before such transaction, whether such obligations are contained in the Company’s
Bylaws, its Certificate of Incorporation, or elsewhere, as the case may be. 
 5.7 Expenses of Counsel. In the event of a transaction
which is a Sale of the Company (as defined in the Voting Agreement (as defined in the Purchase Agreement)), the reasonable fees and disbursements of one counsel for the Investors (“Investor Counsel”), in their capacities as
stockholders, shall be borne and paid by the Company. At the outset of considering a transaction which, if consummated would constitute a Sale of the Company, the Company shall obtain the ability to share with the Investor Counsel (and such
counsel’s clients) and shall share the confidential information (including, without limitation, the initial and all subsequent drafts of memoranda of understanding, letters of intent and other transaction documents and related noncompete,
employment, consulting and other compensation agreements and plans) pertaining to and memorializing any of the transactions which, individually or when aggregated with others would constitute the Sale of the Company. The Company shall be obligated
to share (and cause the Company’s counsel and investment bankers to share) such materials when distributed to the Company’s executives and/or any one or more of the other parties to such transaction(s). In the event that Investor Counsel
deems it appropriate, in its reasonable discretion, to enter into a joint defense agreement or other arrangement to enhance the ability of the parties to protect their communications and other reviewed materials under the attorney client privilege,
the Company shall, and shall direct its counsel to, execute and deliver to Investor Counsel and its clients such an agreement in form and substance reasonably acceptable to Investor Counsel. In the event that one or more of the other party or
parties to such transactions require the clients of Investor Counsel to enter into a confidentiality agreement and/or joint defense agreement in order to receive such information, then the Company shall 

  
 23 

 
share whatever information can be shared without entry into such agreement and shall, at the same time, in good faith work expeditiously to enable Investor Counsel and its clients to negotiate
and enter into the appropriate agreement(s) without undue burden to the clients of Investor Counsel. 
 5.8 Indemnification Matters.
The Company hereby acknowledges that one (1) or more of the directors nominated to serve on the Board of Directors by the Investors (each a “Fund Director”) may have certain rights to indemnification, advancement of expenses
and/or insurance provided by one or more of the Investors and certain of their affiliates (collectively, the “Fund Indemnitors”). The Company hereby agrees (a) that it is the indemnitor of first resort (i.e., its
obligations to any such Fund Director are primary and any obligation of the Fund Indemnitors to advance expenses or to provide indemnification for the same expenses or liabilities incurred by such Fund Director are secondary), (b) that it shall be
required to advance the full amount of expenses incurred by such Fund Director and shall be liable for the full amount of all expenses, judgments, penalties, fines and amounts paid in settlement by or on behalf of any such Fund Director to the
extent legally permitted and as required by the Company’s Certificate of Incorporation or Bylaws of the Company (or any agreement between the Company and such Fund Director), without regard to any rights such Fund Director may have against the
Fund Indemnitors, and, (c) that it irrevocably waives, relinquishes and releases the Fund Indemnitors from any and all claims against the Fund Indemnitors for contribution, subrogation or any other recovery of any kind in respect thereof. The
Company further agrees that no advancement or payment by the Fund Indemnitors on behalf of any such Fund Director with respect to any claim for which such Fund Director has sought indemnification from the Company shall affect the foregoing and the
Fund Indemnitors shall have a right of contribution and/or be subrogated to the extent of such advancement or payment to all of the rights of recovery of such Fund Director against the Company. 

5.9 Right to Conduct Activities. The Company hereby agrees and acknowledges that ARCH (together with its Affiliates),
Partner Fund Management, L.P. (together with its Affiliates, “PFM”), Omega Fund V, L.P. (together with its Affiliates) (collectively, “Omega”), Clough Capital Partners L.P. (together with its Affiliates)
(collectively, “Clough”), Altitude Life Science Ventures Side Fund II, L.P. and Altitude Life Science Venture Funds II, L.P. (together with their Affiliates) (“Altitude”) and Fidelity and the Fidelity Entities are
professional investment funds, and as such invest in numerous portfolio companies, some of which may be deemed competitive with the Company’s business (as currently conducted or as currently propose to be conducted). The Company hereby agrees
that, to the extent permitted under applicable law, neither ARCH, PFM, Omega, Clough, Altitude nor the Fidelity Entities shall be liable to the Company for any claim arising out of, or based upon, (i) the investment by ARCH, PFM, Omega, Clough,
Altitude or any Fidelity Entity, as the case may be, in any entity competitive with the Company, or (ii) actions taken by any partner, officer or other representative of ARCH, PFM, Omega, Clough, Altitude or any Fidelity Entity, as the case may
be, to assist any such competitive company, whether or not such action was taken as a member of the board of directors of such competitive company or otherwise, and whether or not such action has a detrimental effect on the Company; provided,
however, that the foregoing shall not relieve (x) any of the Investors from liability associated with the unauthorized disclosure of the Company’s confidential information obtained pursuant to this Agreement, or (y) any director or
officer of the Company from any liability associated with his or her fiduciary duties to the Company. 

  
 24 

 5.10 Tax Reporting. The Company will comply with any obligation imposed on the Company to
make any filing (including any filing on Internal Revenue Service Form 5471) as a result of any interest that the Company holds in a non-U.S. Person or any activities that the Company conducts outside of the
U.S. and shall include in such filing any information necessary to obviate (to the extent possible) any similar obligation to which any shareholder would otherwise be subject with respect to such interest or such activity. The Company shall promptly
provide each Investor with a copy of any such filing. 
 5.11 Series B Preferred Stock. The Company hereby agrees that it shall not
issue additional shares of Series B Preferred Stock other than (i) pursuant to the Purchase Agreement or that certain Share Purchase Agreement related to Creabilis PLC dated as of December 6, 2016, by and among the Company, the Vendors (as
defined therein) and Shareholder Representative Services LLC, without the prior written consent of the holders of a majority of the then outstanding shares of Series B Preferred Stock or (ii) shares of Series B Preferred Stock issued to
financial institutions, equipment lessors, landlords, brokers or other similar entities in connection with commercial credit arrangements, equipment financings, commercial property lease transactions or similar transactions, the purpose of which is
other than the raising of capital through the sale of equity securities of the Company and the terms of which are approved by the Board of Directors of the Corporation. 

5.12 Termination of Covenants. The covenants set forth in this Section 5, except for Subsections 5.6 and 5.9, shall terminate and
be of no further force or effect (i) immediately before the consummation of the IPO, (ii) when the Company first becomes subject to the periodic reporting requirements of Section 12(g) or 15(d) of the Exchange Act, or (iii) upon
a Deemed Liquidation Event, as such term is defined in the Company’s Certificate of Incorporation (as may be amended from time to time), whichever event occurs first. 

6. Miscellaneous. 
 6.1
Successors and Assigns. The rights under this Agreement may be assigned (but only with all related obligations) (a) by a Holder to a transferee of Registrable Securities that (i) is an Affiliate or Affiliated Fund of a
Holder; (ii) is a Holder’s Immediate Family Member or trust for the benefit of an individual Holder or one or more of such Holder’s Immediate Family Members; or (iii) after such transfer, holds at least 500,000 shares of
Registrable Securities (subject to appropriate adjustment for stock splits, stock dividends, combinations, and other recapitalizations), or (b) by any Fidelity Entity (1) to any other entity managed by a registered investment advisor that
is an Affiliate of a Fidelity Entity or (2) pursuant to a merger or reorganization of a third-party U.S. registered mutual fund with Fidelity or its Affiliated Funds; provided, however, that (x) the Company is, within a reasonable time
after such transfer, furnished with written notice of the name and address of such transferee and the Registrable Securities with respect to which such rights are being transferred; and (y) such transferee agrees in a written instrument
delivered to the Company to be bound by and subject to the terms and conditions of this Agreement, including the provisions of Subsection 2.11. For the purposes of determining the number of shares of Registrable Securities held by a
transferee, the holdings of a 

  
 25 

 
transferee (1) that is an Affiliate, Affiliated Fund or stockholder of a Holder; (2) who is a Holder’s Immediate Family Member; or (3) that is a trust for the benefit of an
individual Holder or such Holder’s Immediate Family Member shall be aggregated together and with those of the transferring Holder; provided further that all transferees who would not qualify individually for assignment of rights
shall have a single attorney-in-fact for the purpose of exercising any rights, receiving notices, or taking any action under this Agreement. The terms and conditions of
this Agreement inure to the benefit of and are binding upon the respective successors and permitted assignees of the parties. Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their
respective successors and permitted assignees any rights, remedies, obligations or liabilities under or by reason of this Agreement, except as expressly provided herein. 

6.2 Governing Law. This Agreement shall be governed by the internal law of the State of Delaware. 

6.3 Counterparts. This Agreement may be executed in two (2) or more counterparts, each of which shall be deemed an original, but
all of which together shall constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (including pdf or any electronic signature complying with the U.S. federal ESIGN Act of 2000, e.g.,
www.docusign.com) or other transmission method and any counterpart so delivered shall be deemed to have been duly and validly delivered and be valid and effective for all purposes.  

6.4 Titles and Subtitles. The titles and subtitles used in this Agreement are for convenience only and are not to be considered in
construing or interpreting this Agreement. 
 6.5 Notices. All notices and other communications given or made pursuant to this
Agreement shall be in writing and shall be deemed effectively given upon the earlier of actual receipt or (i) personal delivery to the party to be notified; (ii) when sent, if sent by electronic mail or facsimile during the
recipient’s normal business hours, and if not sent during normal business hours, then on the recipient’s next business day; (iii) five (5) days after having been sent by registered or certified mail, return receipt requested, postage
prepaid; or (iv) one (1) business day after the business day of deposit with a nationally recognized overnight courier, freight prepaid, specifying next-day delivery, with written verification of receipt.
All communications shall be sent to the respective parties at their addresses as set forth on Schedule A or Schedule B (as applicable) hereto, or, in the case of the Company, to the principal office of the Company, 30699 Russell Ranch
Road, Suite 140, Westlake Village, CA 91362, Attention: General Counsel, or to such email address, facsimile number, or address as subsequently modified by written notice given in accordance with this Subsection 6.5. If notice is given to the
Company, a copy (which shall not constitute notice) shall also be sent to Latham & Watkins LLP, 140 Scott Drive, Menlo Park, California 94025, Attention: Alan Mendelson and Brian Cuneo; email: alan.mendelson@lw.com and brian.cuneo@lw.com;
facsimile: (650) 463-2600. If notice is given to the Investors, a copy shall also be given to (a) Proskauer Rose LLP, One International Place, Boston, MA 02110; Attn: Ori Solomon; Phone: (617) 526-9889; email: osolomon@proskauer.com, and (b) Fenwick & West LLP, 555 California Street, 12th Floor, San Francisco, CA 94104, Attention: Michael
Brown; Phone (415) 875-2432. 

  
 26 

 6.6 Amendments and Waivers. Any term of this Agreement may be amended and the observance
of any term of this Agreement may be waived (either generally or in a particular instance, and either retroactively or prospectively) only with the written consent of the Company and the holders of a majority of the shares constituting Registrable
Securities then outstanding; provided that the Company may in its sole discretion waive compliance with Subsection 2.12(c) (and the Company’s failure to object promptly in writing after notification of a proposed assignment
allegedly in violation of Subsection 2.12(c) shall be deemed to be a waiver); and provided further that any provision hereof may be waived by any waiving party on such party’s own behalf, without the consent of any other
party; and provided further that Section 5.11 may not be amended without the consent of the holders of a majority of the then outstanding shares of Series B Preferred Stock. Notwithstanding the foregoing, this Agreement may not be amended or
terminated and the observance of any term hereof may not be waived with respect to any Investor without the written consent of such Investor, unless such amendment, termination, or waiver applies to all Investors in the same fashion (it being agreed
that a waiver of the provisions of Section 4 with respect to a particular transaction shall be deemed to apply to all Investors in the same fashion if such waiver does so by its terms, notwithstanding the fact that certain Investors may
nonetheless, by agreement with the Cmpany, purchase securities in such transction). Further, this Agreement may not be amended, and no provision hereof may be waived, in each case, in any way which would adversely affect the rights of the Key
Holders hereunder in a manner disproportionate to any adverse effect such amendment or waiver would have on the rights of the Investors hereunder, without also the written consent of the holders of at least a majority of the Registrable Securities
held by the Key Holders. The Company shall give prompt notice of any amendment or termination hereof or waiver hereunder to any party hereto that did not consent in writing to such amendment, termination, or waiver. Any amendment, termination, or
waiver effected in accordance with this Subsection 6.6 shall be binding on all parties hereto, regardless of whether any such party has consented thereto. No waivers of or exceptions to any term, condition, or provision of this Agreement, in
any one or more instances, shall be deemed to be or construed as a further or continuing waiver of any such term, condition, or provision. 

6.7 Severability. In case any one or more of the provisions contained in this Agreement is for any reason held to be invalid, illegal or
unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other provision of this Agreement, and such invalid, illegal, or unenforceable provision shall be reformed and construed so that it will be valid,
legal, and enforceable to the maximum extent permitted by law. 
 6.8 Aggregation of Stock. All shares of Registrable Securities held
or acquired by Affiliates shall be aggregated together for the purpose of determining the availability of any rights under this Agreement and such Affiliated persons may apportion such rights as among themselves in any manner they deem appropriate.

 6.9 Additional Investors. Notwithstanding anything to the contrary contained herein, if the Company issues additional shares of
Preferred Stock after the date hereof, any purchaser of such shares of Preferred Stock may become a party to this Agreement by executing and delivering an additional counterpart signature page to this Agreement, and thereafter shall be deemed an
“Investor” for all purposes hereunder. No action or consent by the Investors shall be required for such joinder to this Agreement by such additional Investor, so long as such additional Investor has agreed in writing to be bound by all of
the obligations as an “Investor” hereunder. 

  
 27 

 6.10 Entire Agreement. This Agreement (including any Schedules and Exhibits hereto)
constitutes the full and entire understanding and agreement among the parties with respect to the subject matter hereof, and any other written or oral agreement relating to the subject matter hereof existing between the parties is expressly
canceled. Upon the effectiveness of this Agreement, the Prior Agreement shall be deemed amended and restated and superseded and replaced in its entirety by this Agreement, and shall be of no further force or effect. 

6.11 Dispute Resolution. Any unresolved controversy or claim arising out of or relating to this Agreement, except as (i) otherwise
provided in this Agreement, or (ii) any such controversies or claims arising out of the Company’s intellectual property rights for which a provisional remedy or equitable relief is sought, shall be submitted to arbitration by one
arbitrator mutually agreed upon by the parties, and if no agreement can be reached within thirty (30) days after names of potential arbitrators have been proposed by the American Arbitration Association (the “AAA”), then by one
arbitrator having reasonable experience in corporate finance transactions of the type provided for in this Agreement and who is chosen by the AAA. The arbitration shall take place in Wilmington, Delaware, in accordance with the AAA rules then in
effect, and judgment upon any award rendered in such arbitration will be binding and may be entered in any court having jurisdiction thereof. There shall be limited discovery prior to the arbitration hearing as follows: (a) exchange of witness
lists and copies of documentary evidence and documents relating to or arising out of the issues to be arbitrated, (b) depositions of all party witnesses, and (c) such other depositions as may be allowed by the arbitrators upon a showing of
good cause. Depositions shall be conducted in accordance with the Delaware Code of Civil Procedure, the arbitrator shall be required to provide in writing to the parties the basis for the award or order of such arbitrator, and a court reporter shall
record all hearings, with such record constituting the official transcript of such proceedings. Each party will bear its own costs in respect of any disputes arising under this Agreement. Each of the parties to this Agreement consents to personal
jurisdiction for any equitable action sought in the U.S. District Court for the District of Delaware or the Court of Chancery of the State of Delaware. 

6.12 Waiver of Jury Trial: EACH PARTY HEREBY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR
ARISING OUT OF THIS AGREEMENT, THE OTHER TRANSACTION DOCUMENTS, THE SECURITIES OR THE SUBJECT MATTER HEREOF OR THEREOF. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL-ENCOMPASSING OF ANY AND ALL DISPUTES THAT
MAY BE FILED IN ANY COURT AND THAT RELATE TO THE SUBJECT MATTER OF THIS TRANSACTION, INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS, TORT CLAIMS (INCLUDING NEGLIGENCE), BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY CLAIMS. THIS
SECTION HAS BEEN FULLY DISCUSSED BY EACH OF THE PARTIES HERETO AND THESE PROVISIONS WILL NOT BE SUBJECT TO ANY EXCEPTIONS. EACH PARTY HERETO HEREBY FURTHER WARRANTS AND REPRESENTS THAT SUCH PARTY HAS REVIEWED THIS WAIVER WITH ITS LEGAL COUNSEL, AND
THAT SUCH PARTY KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL RIGHTS FOLLOWING CONSULTATION WITH LEGAL COUNSEL. 

  
 28 

 6.13 Delays or Omissions. No delay or omission to exercise any right, power, or remedy
accruing to any party under this Agreement, upon any breach or default of any other party under this Agreement, shall impair any such right, power, or remedy of such nonbreaching or nondefaulting party, nor shall it be construed to be a waiver of or
acquiescence to any such breach or default, or to any similar breach or default thereafter occurring, nor shall any waiver of any single breach or default be deemed a waiver of any other breach or default theretofore or thereafter occurring. All
remedies, whether under this Agreement or by law or otherwise afforded to any party, shall be cumulative and not alternative. 
 6.14
Acknowledgment. The Company acknowledges that the Investors are in the business of venture capital investing and therefore review the business plans and related proprietary information of many enterprises, including enterprises which may have
products or services which compete directly or indirectly with those of the Company. Nothing in this Agreement shall preclude or in any way restrict the Investors from investing or participating in any particular enterprise whether or not such
enterprise has products or services which compete with those of the Company. 
 6.15 Massachusetts Business Trust. A copy of the
Agreement and Declaration of Trust of each Investor affiliated with Fidelity, or any affiliate thereof, is on file with the Secretary of State of the Commonwealth of Massachusetts and notice is hereby given that this Agreement is executed on behalf
of the trustees of such Investor or any affiliate thereof as trustees and not individually and that the obligations of this Agreement are not binding on any of the trustees, officers or stockholders of such Investor or any affiliate thereof
individually but are binding only upon such Investor or any affiliate thereof and its assets and property. 
 [Remainder of Page
Intentionally Left Blank] 

  
 29 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	COMPANY:
	
	SIENNA BIOPHARMACEUTICALS, INC.
		
	By:	 	 /s/ Frederick C. Beddingfield, M.D., Ph.D.

	Name:	 	Frederick C. Beddingfield III, M.D., Ph.D.
	 Title:
	 	 President and Chief Executive Officer

 SIGNATURE PAGE TO AMENDED
AND RESTATED INVESTORS’ RIGHTS AGREEMENT OF 

SIENNA BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
 KEY HOLDERS: 

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	INVESTORS:
	
	[●]

 
			
		
	By:	 	  

	Name:	 	
	 Title:
	 	

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	INVESTORS:
	
	FIDELITY MT. VERNON STREET TRUST: FIDELITY GROWTH COMPANY FUND
		
	By:	 	 /s/ Jeffrey Christian

	Name:	 	Jeffrey Christian
	Title:	 	Authorized Signatory
	  
 FIDELITY GROWTH COMPANY COMMINGLED POOL

 

	 By: FIDELITY MANAGEMENT & TRUST CO.

 

	By:	 	 /s/ Jeffrey Christian

	Name:	 	Jeffrey Christian
	Title:	 	Authorized Signatory
	  
 FIDELITY MT. VERNON STREET TRUST: FIDELITY SERIES GROWTH
COMPANY FUND
  

	By:	 	 /s/ Jeffrey Christian

	Name:	 	Jeffrey Christian
	Title:	 	Authorized Signatory

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	INVESTORS:
	  
 CLOUGH HEALTHCARE MASTER FUND, L.P.

 

	By: Clough Capital Partners L.P.
	 Its: Investment Manager
  

	By:	 	 /s/ Daniel J. Gillis

	Name:	 	Daniel J. Gillis
	Title:	 	Chief Compliance Officer
	
	CLOUGH GLOBAL OPPORTUNITIES FUND
	  
 By: Clough Capital Partners L.P.

	Its: Investment Adviser
		
	By:	 	 /s/ Daniel J. Gillis

	Name:	 	Daniel J. Gillis
	Title:	 	Chief Compliance Officer
	  
 CLOUGH GLOBAL EQUITY FUND

 

	By: Clough Capital Partners L.P.
	 Its: Investment Adviser
  

	By:	 	 /s/ Daniel J. Gillis

	Name:	 	Daniel J. Gillis
	Title:	 	Chief Compliance Officer

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 INVESTORS:
  

	 OMEGA FUND V, L.P.
  

	By: Omega Fund V GP, L.P.
	 Its: General Partner
  

	By: Omega Fund V GP Manager, Ltd.
	 Its: General Partner
  

	By:	 	 /s/ Richard Lim

	Name:	 	Richard Lim
	Title:	 	Director

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 INVESTORS:
  

	 ARCH VENTURE FUND VIII, L.P.
  

	By: ARCH Venture Partners VIII, L.P.
	 Its: General Partner
  

	By: ARCH Venture Partners VIII, LLC
	 Its: General Partner
  

	By:	 	 /s/ Mark McDonnell

	Name:	 	Mark McDonnell
	Title:	 	Managing Director
	  
 ARCH VENTURE FUND VIII OVERAGE, L.P.

 

	By: ARCH Venture Partners VIII, L.P.
	 Its: General Partner
  

	By: ARCH Venture Partners VIII, LLC
	 Its: General Partner
  

	By:	 	 /s/ Mark McDonnell

	Name:	 	Mark McDonnell
	Title:	 	Managing Director

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 INVESTORS:
  

	PFM HEALTHCARE EMERGING GROWTH MASTER FUND, L.P.
	  
 By: Partner Fund Management, L.P.

	 Its: Investment Advisor
  

	By:	 	 /s/ Darin Sadow

	Name:	 	Darin Sadow
	Title:	 	General Counsel & CCO
	  
 PFM HEALTHCARE OPPORTUNITIES MASTER FUND, L.P.

 

	By: Partner Fund Management, L.P.
	 Its: Investment Advisor
  

	By:	 	 /s/ Darin Sadow

	Name:	 	Darin Sadow
	Title:	 	General Counsel & CCO

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 INVESTORS:
  

	 PFM HEALTHCARE PRINCIPALS FUND, L.P.
  

	 By: Partner Investment Management, L.P.
  

	By:	 	 /s/ Darin Sadow

	Name:	 	Darin Sadow
	Title:	 	General Counsel & CCO

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 INVESTORS:
  

	 ALTITUDE LIFE SCIENCE VENTURES FUND II, L.P.

 

	By:	 	 /s/ David Maki

	Name:	 	David Maki
	Title:	 	Managing Member
	  
 ALTITUDE LIFE SCIENCE VENTURES SIDE FUND II,
L.P.
  

	By:	 	 /s/ David Maki

	Name:	 	David Maki
	Title:	 	Managing Member

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 INVESTORS:
  

	 VENVEST BIOTECH, LLC
  

	By:	 	 /s/ George Azar

	Name:	 	George Azar
	Title:	 	Managing Member

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 INVESTORS:
  

	 DAVID E.I. PYOTT LIVING TRUST
  

	By:	 	 /s/ David E.I. Pyott

	Name:	 	David E.I. Pyott
	 Title:
	 	 Trustee

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 INVESTORS:
  

	 VP COMPANY INVESTMENTS 2016, LLC
  

	By:	 	 /s/ Alan Mendelson

	Name:	 	Alan C. Mendelson
	Title:	 	Member, Management Committee

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 INVESTORS:
  

	 THE ALAN C. & AGNÈS B. MENDELSON FAMILY TRUST

 

	By:	 	 /s/ Alan C. Mendelson

	Name:	 	Alan C. Mendelson
	Title:	 	Trustee

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 INVESTORS:
  

	 KELL S CANNON AND STEPHANIE S MUEHLHAUSEN

 

	By:	 	 /s/ Kell S. Cannon

	Name:	 	Kell S Cannon
		
	By:	 	 /s/ Stephanie S. Muehlhausen

	Name:	 	Stephanie S Muehlhausen

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

	
	 INVESTORS:
  

	 /s/ Anita Saluja

	Anita Saluja

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 INVESTORS:
  

	 LASK FAMILY TRUST
  

	By:	 	 /s/ Gary Lask

	Name:	 	Gary Lask
	Title:	 	Trustee

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

	
	 INVESTORS:
  

	 /s/ Scott M. Freund

	 Scott M. Freund

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

	
	 INVESTORS:
  

	 /s/ Eileen More

	Eileen More

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 INVESTORS:
  

	 THE BALDRIDGE FAMILY TRUST
  

	By:	 	 /s/ Trustee Baldridge Family Trust

	Name:	 	Trustee Baldridge Family Trust
	Title:	 	Trustee

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 INVESTORS:
  

	 PRELUDE OPPORTUNITY FUND, LP
  

	By:	 	 /s/ Gavin Saitowitz

	Name:	 	Gavin Saitowitz
	Title:	 	Managine Member of the General Partner

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

	
	 INVESTORS:
  

	 /s/ Brandith Irwin /s/ Mark McPherson

	 Brandith Irwin and Mark McPherson

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

	
	 INVESTOR:
  

	 /s/ Matthew M. Avram

	Mathew M. Avram, MD, JD

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	INVESTORS:
	  
 PENSCO TRUST COMPANY CUSTODIAN FBO TRACY KELLEY
IRA
  

	By:	 	 /s/ Tracy Fawn Kelley

	Name:	 	Tracy Fawn Kelley

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

	
	 INVESTOR:
  

	 /s/ Dr. Fuad S. Ashkar

	 Dr. Fuad S. Ashkar

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

	
	 KEY HOLDERS:
  

	 /s/ Todd Harris

	Todd Harris

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

	
	 KEY HOLDERS:
  

	 /s/ Frederick C. Beddingfield, M.D., Ph.D.

	Frederick C. Beddingfield III, M.D., Ph.D.

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

	
	 KEY HOLDERS:
  

	 /s/ Ted Schwarz

	Ted Schwarz

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

	
	 KEY HOLDERS:
  

	 /s/ Ryan Harris

	Ryan Harris

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

	
	 KEY HOLDERS:
  

	 /s/ Richard Harris

	Richard Harris

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 KEY HOLDERS:
  

	 MLPF&S C/F ROBERT MORE IRRA
  

	By:	 	 /s/ Robert More

	Name:	 	Robert More
	Title:	 	Trustee

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 KEY HOLDERS:
  

	 NUNATAK VENTURES, LLC
  

	By:	 	 /s/ Jared Smith

	Name:	 	Jared Smith
	Title:	 	Managing Member

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	 KEY HOLDERS:
  

	 BIOBRIT, LLC
  

	By:	 	 /s/ Daniel M. Bradbury

	Name:	 	Daniel M. Bradbury
	Title:	 	Managing Member

  

SIGNATURE PAGE TO AMENDED AND RESTATED
INVESTORS’ RIGHTS AGREEMENT OF 
 SIENNA
BIOPHARMACEUTICALS, INC. 

 INVESTORS 

ARCH VENTURE FUND VIII, L.P. 
 c/o ARCH Venture Partners VIII,
L.P. 
 8725 W. Higgins Road, Suite 290 
 Chicago, IL 60631 

Attn: Mark McDonnell 
 Phone: (773)
380-6600 
 Fax: (773) 380-6606 

Email: ############### 
 With a mandatory
copy, which shall not constitute notice, to: 
 Proskauer Rose LLP 

One International Place 
 Boston,
MA 02110 
 Attn: Ori Solomon 

Phone: (617) 526-9889 

Fax: (617) 526-9899 

Email: ############ 
 BioBrit, LLC 

5462 Soledad Road 
 La Jolla, CA 92037 

########### 
 Greystoke Associates, LLC 

Attn: Greg Stokes 
 c/o Monarch Entity Services 

P.O. Box 957 
 Wilmington, DE 19899-0957 

########### 
 Josh Harris 

########### 
 ####### ## ###### 

############# 
 McGuire Specialty Investments, LLC 

Attn: Lake T. McGuire 
 2033 Mackinnon Ave. 

Cardiff by the Sea, CA 92007 
 Eileen M. More 

######## 
 #### ## ###### 

 Robert More 
 ######
##### 
 ###### ###### 
 Nunatak Ventures, LLC 

Attn: Jared Smith 
 412 Olive Avenue, Suite 490 

Huntington Beach, CA 92648 
 Steve Oldenburg 

######## ####### 
 ##### ## ###### 

Richard A. Harris A Professional Corporation Employees Profit Sharing Plan 

c/o Richard Harris Law Firm 
 801 South Fourth Street 

Las Vegas, NV 89101 
 Lindy Schermerhorn 

#### ######### 
 #### ## ###### 

Ted Schwarz 
 #### ###### 

###### ## ###### 
 PFM Healthcare Opportunities Master Fund, L.P.

 4 Embarcadero Center 
 Suite 3500 

San Francisco, CA 94111 
 PFM Healthcare Emerging Growth Master
Fund, L.P. 
 4 Embarcadero Center 
 Suite 3500 

San Francisco, CA 94111 
 PFM Healthcare Principals Fund, L.P.

 4 Embarcadero Center 
 Suite 3500 

San Francisco, CA 94111 
 Venvest Biotech, LLC 

3400 East Coliseum Blvd., Ste. 100 
 Fort Wayne, IN 46805 

Attn: George Azar 

 Altitude Life Science Ventures Fund II, L.P. 

Attn: David Maki 
 1014 Market St, Suite 200 

Kirkland, WA 98033 
 Email: ########### 

Altitude Life Science Ventures Side Fund II, L.P. 
 c/o Altitude
Life Science Venture Funds II, L.P. 
 Attn: David Maki 
 1014
Market St, Suite 200 
 Kirkland, WA 98033 
 Email: ##########

 Geoffrey von Maltzahn 
 ## ###### ##### 

######## ## ##### 
 Beddingfield Family Trust 

### ########## 
 ######### ## ###### 

Beddingfield Children’s Trust fbo CATHERINE SARA BEDDINGFIELD 

### ####### #### 
 ######### ## ###### 

Beddingfield Children’s Trust fbo CLAIRE ELIZABETH BEDDINGFIELD 

### ######### 
 ######### ## ###### 

David E.I. Pyott Living Trust 
 ## ### ##### 

###### ## ###### 
 Andalucia Ventures LLC 

#### ######### 
 ######## ## ###### 

Attn: Keith Leonard 
 PENSCO Trust Company, FBO Anda Ashkar IRA

 P.O. Box 173859 
 Denver, CO 80217 

Pensco Trust Company, FBO Anda Ashkar ROTH IRA 
 P.O. Box 173859

 Denver, CO 80217 

 Anda Theresa Ashkar 

#### ####### ##### 
 ######## ## ###### 

Diane Marie Stroehmann 
 ### ######### 

######### ## ###### 
 The Oracle Investment Group, a Delaware
limited liability company 
 15480 Annapolis Road, Suite 202 PMB 198 

Bowie, M.D. 20715 
 Attn: Jim Dibiasi 

PENSCO Trust Company, Custodian FBO James J. DiBiasi IRA 
 #
############# #### 
 ######## ## ##### 
 Cindy DiBiasi Living
Trust Dated 12-28-2012 
 ####### ####### ####### 

##### ## ##### 
 PENSCO Trust Company, Custodian FBO Kell Cannon
IRA 
 ####### ####### ####### 
 ##### ## ##### 

PENSCO Trust Company, Custodian FBO James Kelley IRA 
 #######
####### ####### 
 ##### ## ##### 
 Seth J. Orlow M.D., Ph.D.

 ####### ####### ####### 
 ##### ## ##### 

PENSCO Trust Company Custodian FBO Michelle Kobashi SEP-IRA 

P.O. Box 173859 
 Denver, CO 80217 

Scott Romesser 
 ####### ####### ####### 

##### ## ##### 
 Lask Family Trust 

####### ####### ####### 
 ##### ## ##### 

 Sean Burton 

####### ####### ####### 
 ##### ## ##### 

Hudson Capital Partners 
 Attn: Peter Hudson, M.D. 

Alta Partners 
 ####### ####### ####### 

##### ## ##### 
 Ram Pasture, LLC 

####### ####### ####### 
 ##### ## ##### 

PENSCO Trust Company Custodian FBO William Leitner IRA 
 P.O. Box
173859 
 Denver, CO 80217 
 PENSCO Trust Company, FBO Tamara
Leitner IRA 
 P.O. Box 173859 
 Denver, CO 80217 

Madison Trust Company, Custodian FBO Tamara Ferretti M1602090 

Investor Address: ############ ## ##### 
 Mailing Address:
########## ######## 
 Casey Gosnell 
 ####### ###### 

###### ## ###### 
 PENSCO Trust Company Custodian FBO Casey
Gosnell SEP-IRA 
 P.O. Box 173859 

Denver, CO 80217 
 Lizzul Living Trust, Paul F. Lizzul and Dawn
Marie Lizzul TTEEs 
 ####### ###### 
 ###### ## ###### 

Ryan and Shima Baughman 
 ####### ###### 

###### ## ###### 
 ### ### #### 

############# 
 David Hatch 

####### ###### 
 ###### ## ###### 

### ### #### 
 ############# 

 J-4000 Investments, LLC 

4394 Sheffield Dr. 
 Provo, UT 64604 

801.362.4000 
 ######## 

Pharus Investment Partners LLC—Series 5 
 551 Fifth Avenue,
Suite 1125 
 New York, NY 10176 
 ATTN: Michael Goodman 

Paul Trapp 
 ## ######## 

###### ## ####### 
 VP Company Investments 2008, LLC 

c/o Latham & Watkins LLP 
 Attn: Alfred Harutunian 

555 West Fifth Street – Suite 800 
 Los Angeles, CA
90013-1021 
 Fax: (213) 891-1200 

Email: ############### 
 VP Company Investments 2016, LLC 

c/o Latham & Watkins LLP 
 Attn: Alfred Harutunian 

555 West Fifth Street – Suite 800 
 Los Angeles, CA
90013-1021 
 Fax: (213) 891-1200 

Email: ########## 
 Tamara Leitner 

#### ##### #### ##### 
 ####### ## ###### 

PENSCO Trust Company Custodian FBO Corey Josenhans IRA 
 P.O. Box
173859 
 Denver, CO 80217 
 Corey Josenhans 

#### ########### 
 ######### ## ###### 

Alan C. & Agnès B. Mendelson Family Trust 
 ## ##
####### 
 ####### ## ###### 
 Fax: ### ### ##### 

Email: ############## 

 Michelle Kobashi 

#### ####### 
 ####### ## ###### 

PENSCO Trust Company Custodian FBO Michael Conway-IRA 

P.O. Box 173859 
 Denver, CO 80217 

The Kobashi Revocable Living Trust dtd 10/21/88 As Amended 12/10/98 Richard & Herlinda Kobashi, Co-Trustees

 ### ######## 
 ####### ## ###### 

Adam Muth 
 ### ####### ## 

####### ## ###### 
 Jacob Lewis 

###### ##### 
 ####### ## ###### 

Kevin Ferretti 
 #### ####### 

####### ## ###### 
 Robert B. and Tina M. Pierce 

### ####### 
 ####### ## ###### 

George & Judy Leitner 
 ###### ####### 

####### ## ###### 
 Thomas & Natalie Muth 

####### ####### 
 ######### ## ##### 

Michael Conway 
 ####### ######## 

######## ## ###### 
 Jared Younger 

##### ####### 
 ######## ## ###### 

 Mark V. Roeder 
 c/o
Latham & Watkins LLP 
 140 Scott Drive 
 Menlo Park,
CA 94025 
 ARCH Venture Fund VIII Overage, L.P. 
 c/o ARCH
Venture Partners VIII, L.P. 
 8755 West Higgins Road, Suite 1025 

Chicago, IL 60631 
 Attn: Mark McDonnell 

Email: ############# 
 Partner Investments, L.P. 

4 Embarcadero Center 
 Suite 3500 

San Francisco, CA 94111 
 Bonderman Family Limited Partnership

 c/o Leonard A. Potter 
 Wildcat Capital Management, LLC 

888 Seventh Avenue, 37th floor 
 New York, NY 10106 

Email: ########### 
 Gregory F. Kiernan 

#### ###### 
 ######## ## ####### 

Email: ########## 
 MDRB Partnership 

Attn: Esther Wynter 
 ##### ### ##### 

######## ######### 
 Email: ########### 

Joshua A. Kazam Irrevocable Grantor Trust 
 Attn: Joshua Kazam

 Two River 
 689 Fifth Ave, 12th Floor 

New York, NY 10022 
 Email: ######### 

 David M. Tanen Revocable Grantor Trust 

Attn: David Tanen 
 Two River 

689 Fifth Ave, 12th Floor 
 New York, NY 10023 

Email: ######### 
 Bellco Capital 

Attn: Esther Wynter 
 811 Strada Vecchia 

Los Angeles, CA 90077 
 Email: ############ 

Cynthia Butitta 
 ############# 

########## ## ###### 
 Email: ######### 

Stuart Ross 
 Troutman Sanders, LLP 

401 9th St. NW, Suite 1000 
 Washington DC 20004 

Email: ########## 
 PENSCO Trust Company, FBO Tamara Leitner IRA

 P.O. Box 173859 
 Denver, CO 80217 

With a copy to (which shall not constitute notice): 
 ###########

 Kirstein-Wholey Family Trust 
 c/o Kim Kirstein 

######## ####### 
 ######## ## ###### 

Email: ############## 
 Haywood Dermatology 

1500 North Dixie Highway, Suite 303 
 West Palm Beach, FL 33401

 Attn: Ken Beer 
 Email: ########## 

MLPF&S c/f Robert More IRRA 
 P.O. Box 196 

5014 El Acebo Del Norte 
 Rancho Santa Fe, CA 92067 

 Donna Volpitta 2014 Irrevocable Trust 

Attn: Donna Volpitta, Trustee 
 ############ 

######## ## ###### 
 BioBrit, LLC 

5462 Soledad Road 
 La Jolla, CA 92037 

########## 
 WS Investments Company, LLC (2013A) 

Attn: Jim Terranova 
 650 Page Mill Road 

Palo Alto, CA 94304 
 ########## 

Benjamin David Sullivan 
 ####### ###### 

######### ## ###### 
 ########### 

Zeyad Moussa 
 ###### ####### 

######## ## ###### 
 ########### 

Self Directed IRA Services Inc., Custodian FBO Lakins T. McGuire IRA 

2477 Caminito Ocean Cove 
 Cardiff by the Sea, CA 92007 

############### 
 Self Directed IRA Services Inc., Custodian FBO
Reid McGuire IRA 
 ######## 
 ######## ## ##### 

############# 
 Daniel Janney 

One Embarcadero Center, Suite 3700 
 San Francisco, CA 94111 

########### 
 Greystoke Associates, LLC 

Attn: Greg Stokes 
 c/o Monarch Entity Services 

P.O. Box 957 
 Wilmington, DE 19899-0957 

########### 

 Raleigh Radiology Associates, Inc. Profit Sharing Plan FBO Jason Harris 

10752 Trego Trail 
 Raleigh, NC 27614 

Ryan Harris 
 c/o Harris Personal Injury 

301 Mission Avenue, Suite 203 
 Oceanside, CA 92054 

################# 
 L. Randall Harris 

############# 
 ########### ## ###### 

############# 
 Lindy Schermerhorn 

###### ####### 
 ######### ## ###### 

Lake T. McGuire 
 #### ########### 

######## ## ###### 
 ############ 

Reid McGuire 
 ##### ###### 

######### ## ###### 
 ########### 

Jason Harris 
 ####### ##### 

######## ## ###### 
 Geoffrey von Maltzahn 

##### ##### 
 ####### ## ##### 

Nanocomposix, Inc. 
 Attn: Steve Oldenburg 

###### ####### 
 ########### ## ##### 

Clark Seegmiller 
 c/o Seegmiller & Associates 

10801 West Charleston Boulevard 
 Las Vegas, Nevada 89135 

################## 

 Fidelity Mt. Vernon Street Trust: Fidelity Growth Company Fund 

c/o BNY Mellon 
 Attn: Stacey Wolfe 

525 William Penn Place Rm 0400 
 Pittsburgh, PA 15259 

Email: ############ 
 Fax number:
412-236-1012 
 Fidelity Growth Company Commingled Pool 

By: Fidelity Management & Trust Co. 
 c/o Brown Brothers
Harriman & Co. 
 Harborside Financial Center 
 1150
Plaza Five 
 Jersey City NJ 07311 
 Attn: Michael Lerman 15th
Floor 
 Corporate Actions 
 Email: ########### 

Fax number: 617-772-2418 

Fidelity Mt. Vernon Street Trust: Fidelity Series Growth Company Fund 

c/o State Street Bank & Trust 
 PO Box 5756 

Boston, Massachusetts 02206 
 Attn: WAVELENGTH + CO Fidelity Mt.
Vernon Street Trust: Fidelity Series Growth Company Fund 
 Email: ############## 

Fax number: 617-988-9110 

Clough Global Opportunities Fund 
 c/o Clough Capital Partners
L.P. 
 One Post Office Square, 39th Floor 
 Boston, MA 02109

 Clough Global Equity Fund 
 c/o Clough Capital Partners L.P.

 One Post Office Square, 39th Floor 
 Boston, MA 02109 

Clough Healthcare Master Fund, L.P. 
 c/o Clough Capital Partners
L.P. 
 One Post Office Square, 39th Floor 
 Boston, MA 02109

 Omega Fund V, L.P. 

c/o Omega Fund Management LLC 
 185 Dartmouth Street, Suite 502

 Boston, MA 02116 
 Attn. Anne-Mari Paster 

Kell S. Cannon and Stephanie S. Muehlhausen 
 ######## #######

 ######## ## ##### 
 Anita Saluja 

######## ###### 
 ######## ## ##### 

Scott M. Freund 
 ##### ### ##### 

######## ## ##### 
 The Baldrige Family Trust 

#### ###### ### 
 ######### ## ###### 

Prelude Opportunity Fund, LP 
 #### ######### ## 

######### ## ###### 
 Brandith Irwin and Mark McPherson 

######## ####### 
 ######## ## ###### 

Mathew M. Avram 
 ### ######## 

######## ## ##### 
 PENSCO Trust Company Custodian FBO Tracey
Kelley IRA 
 8500 Purnell Ridge Rd 
 Wake Forest, NC 27587 

Dr. Fuad S. Ashkar 
 ####### ###### 

######## ## ###### 
 AbbVie International S.à. r.l. 

26 Boulevard Royal 

L-2449 Luxembourg 

 Alfredo Boni 
 c/o
Creabilis Therapeutics 
 S.r.l., Bioindustry Park del Canavese 

Via Ribes 5 
 10010 Colleretto Giacosa, TO, Italy 

Eliot Forster 
 ##### #### 

###### ######## 
 George Homer 

c/o Peter T. Healy, Esq. 
 O’Melveny & Myers LLP

 Two Embarcadero Center, 28th Floor 

San Francisco, CA 94111 
 The Kent County Council 

Sessions House, County Hall 
 Maidstone, Kent, ME14 IXQ 

Kreos Cpaital IV (Expert Fund) Limited 
 52 Esplanade 

St Helier, Jersey 
 Alexander Leech 

###### ##### 
 #### ##### ##### 

Catherine Moukheibir 
 ####### ###### 

#### #### ##### 
 NeoMed IV Extension L.P. 

13 Castle Street, Jersey JE4 5UT 
 Channel Islands 

Simon Russell 
 ######### ## 

######### ######### 
 Sofinnova Capital V FCPR 

Immeuble le Centorial 

16-18 rue du 4 Septembre 

75002, Paris, France 

 SCHEDULE B 

KEY HOLDERS 
 Todd Harris 

#### ###### 
 ####### ## ###### 

### ### ##### 
 ############# 

BioBrit, LLC 
 5462 Soledad Road 

La Jolla, CA 92037 
 ######### 

Donna Volpitta 2014 Irrevocable Trust 
 Attn: Donna Volpitta,
Trustee 
 ## ########## 
 ######### ## ###### 

MLPF&S c/f Robert More IRRA 
 P.O. Box 196 

5014 El Acebo Del Norte 
 Rancho Santa Fe, CA 92067 

########### 
 Nunatak Ventures, LLC 

Attn: Jared Smith 
 412 Olive Avenue, Suite 490 

Huntington Beach, CA 92648 
 Richard Harris 

c/o Richard Harris Law Firm 
 801 South Fourth Street 

Las Vegas, Nevada 89101 
 ############ 

L. Randall Harris 
 #### ###### 

######## ## ##### 
 #############3 

Greystoke Associates, LLC 
 Attn: Greg Stokes 

c/o Monarch Entity Services 
 P.O. Box 957 

Wilmington, DE 19899-0957 
 ############## 

 Ryan Harris 
 c/o
Harris Personal Injury 
 301 Mission Avenue, Suite 203 

Oceanside, CA 92054 
 ################## 

Alice A. Chen 
 ##### ###### 

######## ## ###### 
 Ted Schwarz 

###### ##### #### 
 ####### ## ###### 

Nanocomposix, Inc. 
 Attn: Steve Oldenburg 

4878 Ronson Court, Suite K 
 San Diego, CA 92111EX-10.4(a)

 Exhibit 10.4(a) 

OFFICE LEASE 
 by and
between 
 TEACHERS INSURANCE AND ANNUITY ASSOCIATION OF AMERICA 

for the benefit of its Real Estate Account 

(“Landlord”) 

and 
 SIENNA
BIOPHARMACEUTICALS, INC. 
 a Delaware corporation 

(“Tenant”) 

Dated as of 
 May
10, 2016 

							
	 LEASE OF PREMISES
	  	 	1	 
	 BASIC LEASE PROVISIONS
	  	 	1	 
	 STANDARD LEASE PROVISIONS
	  	 	5	 
	 1.
	  	 TERM
	  	 	5	 
	 2.
	  	 BASE RENT AND SECURITY DEPOSIT
	  	 	6	 
	 3.
	  	 ADDITIONAL RENT
	  	 	7	 
	 4.
	  	 IMPROVEMENTS AND ALTERATIONS
	  	 	14	 
	 5.
	  	 REPAIRS
	  	 	16	 
	 6.
	  	 USE OF PREMISES
	  	 	17	 
	 7.
	  	 UTILITIES AND SERVICES
	  	 	19	 
	 8.
	  	 NON-LIABILITY AND INDEMNIFICATION OF LANDLORD;
INSURANCE
	  	 	22	 
	 9.
	  	 FIRE OR CASUALTY
	  	 	25	 
	 10.
	  	 EMINENT DOMAIN
	  	 	27	 
	 11.
	  	 ASSIGNMENT AND SUBLETTING
	  	 	27	 
	 12.
	  	 DEFAULT
	  	 	31	 
	 13.
	  	 ACCESS; CONSTRUCTION
	  	 	33	 
	 14.
	  	 BANKRUPTCY
	  	 	34	 
	 15.
	  	 SUBSTITUTION OF PREMISES
	  	 	35	 
	 16.
	  	 SUBORDINATION; ATTORNMENT; ESTOPPEL CERTIFICATES
	  	 	35	 
	 17.
	  	 SALE BY LANDLORD; TENANT’S REMEDIES; NONRECOURSE LIABILITY
	  	 	36	 
	 18.
	  	 PARKING; COMMON AREAS
	  	 	37	 
	 19.
	  	 MISCELLANEOUS
	  	 	39	 

 LIST OF EXHIBITS 
  

			
	 Exhibit A-l
	  	 Floor Plan(s)

	 Exhibit A-2
	  	 Legal Description of the Project

	 Exhibit B
	  	 Work Letter

	 Exhibit B-l
	  	 Tenant Improvements

	 Exhibit B-2
	  	 Description of Certain Tenant Improvements

	 Exhibit B-3
	  	 Exiting Furniture Inventory

	 Schedule One
	  	 Freestanding Furniture to be Removed

	 Exhibit C
	  	 Building Rules and Regulations

	 Exhibit D
	  	 Form Tenant Estoppel Certificate

	 Exhibit E
	  	 Tenant’s Commencement Letter

	 Exhibit F
	  	 Form of Letter of Credit

	 Exhibit G
	  	 Janitorial Specifications

	 Exhibit H
	  	 Reserved Parking

		
	 Addendum One
	  	 One Renewal Option at Market

  
 -i- 

 OFFICE LEASE 

THIS OFFICE LEASE (this “Lease”) is made between TEACHERS INSURANCE AND ANNUITY
ASSOCIATION OF AMERICA, for the benefit of its Real Estate Account (“Landlord”), and the Tenant described in Item 1 of the Basic Lease Provisions. 

LEASE OF PREMISES 

Landlord hereby leases to Tenant and Tenant hereby leases from Landlord, subject to all of the terms and conditions set forth herein, those
certain premises (the “Premises”) described in Item 3 of the Basic Lease Provisions and as shown in the drawing attached hereto as Exhibit
A-1. The Premises are located in the Building described in Item 2 of the Basic Lease Provisions. The Building is located on that certain land (the
“Land”) more particularly described on Exhibit A-2 attached hereto, which is also improved with landscaping, parking facilities and other
improvements, fixtures and common areas and appurtenances now or hereafter placed, constructed or erected on the Land (sometimes referred to herein as the “Project”). 

BASIC LEASE PROVISIONS 
  

					
	1.	  	Tenant:	  	Sienna Biopharmaceuticals, Inc., a Delaware corporation (“Tenant”)
			
	2.	  	Building:	  	 Building III
 Westlake North Business
Park
 30699 Russell Ranch Road
 Westlake Village, California
91362

			
	3.	  	Description of Premises:	  	Suite 140
			
		  	Rentable Area:	  	7,002 square feet; provided, however, if the demising wall for the Premises is located in a location substantially different that it is shown on Exhibit B-2, Tenant shall have the right to
request a remeasurement of the Rentable Area of the Premises per BOMA using an add-on factor of 1.12728.
			
		  	Building Size:	  	133,711 square feet (subject to Paragraph 18)
			
	4.	  	Tenant’s Proportionate Share:	  	 As to the Building: 5.24% (7,002 rsf / 133,711 rsf)

As to the Project: 3.55% (7,002 rsf / 197,366 rsf)
 (See
Paragraph 3)

			
	5.	  	Base Rent:	  	(See Paragraph 2)
			
		  	 Month 1*:
 Monthly Installment:
	  	$18,205.20 ($2.60/square foot of Rentable Area/month)
			
		  	 *  If the Commencement Date is a day other than the first day of a calendar month,
then Month 1 shall commence on the Commencement Date and end on the last day of the calendar month following the date that is thirty (30) days after the Commencement Date. For the avoidance of doubt, if the Commencement Date is a day
other
	  	

  
 1 

					
			
		  	than the first day of a calendar month, then Month 1 will be longer than one month, and Month 2 will begin on the first day of a calendar month.	  	
			
		  	 Months 2 to 5, inclusive:
 Monthly
Installment:
	  	
$0.00 ($2.60 (abated)/square foot of Rentable Area/month)
			
		  	 Months 6 to 12, inclusive:
 Monthly
Installment:
	  	
$18,205.20 ($2.60/square foot of Rentable Area/month)
			
		  	 Months 13 to 24, inclusive:
 Monthly
Installment:
	  	
$18,751.36 ($2.68/square foot of Rentable Area/month)
			
		  	 Months 25 to 36, inclusive:
 Monthly
Installment:
	  	
$19,313.90 ($2.76/square foot of Rentable Area/month)
			
		  	 Months 37 to 40, inclusive:
 Monthly
Installment:
	  	
$19,893.31 ($2.84/square foot of Rentable Area/month)
			
	6.	  	Installment Payable Upon Execution:	  	$18,205.20 (to be credited toward the monthly installment of Base Rent payable for Month 1 of the Initial Term)
			
	7.	  	Security Deposit Payable Upon Execution:	  	$109,231.20 in the form of a letter of credit (See Paragraph 2(c))
			
	8.	  	Base Year for Operating Expense:	  	Calendar Year 2016 (See Paragraph 3)
			
	9.	  	Initial Term:	  	Forty (40) months, commencing on the Commencement Date and ending on last day of the calendar month in which the fortieth (40th) month anniversary of the Commencement Date occurs (See Paragraph 1)
			
	10.	  	Estimated Commencement Date:	  	August 1, 2016
			
	11.	  	Estimated Termination Date:	  	November 30, 2019
			
	12.	  	Broker(s) (See Paragraph 19(k)):	  	
			
		  	Landlord’s Broker:	  	 IDS Real Estate Group
 515 S. Figueroa
Street, 16th Floor
 Los Angeles, California 90071

			
		  		  	 Jones Lang LaSalle
 21080 Centre Pointe
Parkway, Suite 102
 Santa Clarita, California 91350

			
		  	Tenant’s Broker:	  	 Cresa Los Angeles
 20950 Warner Center Lane,
Suite B
 Woodland Hills, California 91362

  
 2 

					
			
	13.	  	Number of Parking Spaces:	  	Twenty-Eight (28) total unreserved parking spaces, from which Tenant may elect from time to time to have up to four (4) spaces be covered and reserved parking spaces as set forth
on Exhibit H hereto, throughout the Lease Term, as may be extended, at no additional charge to Tenant.
			
	14.	  	Addresses for Notices:	  	
			
		  	 To:            TENANT:

 
 Prior to occupancy of the Premises:

 
 Sienna Biopharmaceuticals, Inc.

2945 Townsgate Road, Suite 200
 Westlake Village, CA 91631

Attn: CFO & CEO
	  	 To: LANDLORD:
  

TIAA-CREF
 Attn: Global
Real Estate Asset Management
 730 3rd Ave, 14th floor

New York, NY 10017

			
		  	 After occupancy of the Premises:
  

Sienna Biopharmaceuticals, Inc.
 Building III, Suite 140

30699 Russell Ranch Road
 Westlake Village, California 91362

Attn: CFO & CEO
	  	 With a copy to:
  

TIAA-CREF
 Attn: Global
Real Estate Asset Management
 4675 MacArthur Court, Suite 1110

Newport Beach, CA 92660

			
		  		  	 And an additional copy to:
  

TIAA-CREF
 Attn: Global
Real Estate Legal
 4675 MacArthur Court, Suite 1100
 Newport
Beach, CA 92660

			
		  		  	 And an additional copy to:
  

IDS Real Estate Group
 Attn: David Saeta

515 South Figueroa Street, Sixteenth Floor
 Los Angeles, CA
90071

			
	15.	  	Address for Payment of Rent:	  	 All payments payable under this Lease shall be sent to Landlord at:
  

Teachers Insurance and Annuity Association
 c/o IDS Real Estate
Group
 File 749023
 Los Angeles, CA 90074-9023
  
 or to such other address as Landlord may
designate in writings.

			
	16.	  	Guarantor:	  	None

  
 3 

					
	17.	  	Effective Date:	  	See Cover Page
			
	18.	  	Tenant Improvements	  	See Exhibit B
			
	19.	  	The “State” is the State of California.	  	

 This Lease consists of the foregoing introductory paragraphs and Basic Lease Provisions, the provisions of the Standard Lease
Provisions (the “Standard Lease Provisions”) (consisting of Paragraph 1 through Paragraph 19 which follow) and Exhibits A-1
through Exhibit A-2 and Exhibits B through Exhibit H, and Addendum One (One Renewal Option
at Market), all of which are incorporated herein by this reference. In the event of any conflict between the provisions of the Basic Lease Provisions and the provisions of the Standard Lease Provisions, the Standard Lease Provisions shall control.

  
 4 

 STANDARD LEASE PROVISIONS 

 

	1.	TERM 

 (a) The Initial Term of this Lease and the Rent (defined below) shall
commence on the earlier of (i) the date which is fifteen (15) days after the date that the Tenant Improvements are Substantially Completed, or (ii) the date which is fifteen (15) days after the date the Tenant Improvements would
have been Substantially Completed except for Tenant Delays (the earlier of (i) or (ii), the “Commencement Date”). Unless earlier terminated in accordance with the provisions hereof, the Initial Term of this Lease shall be the
period shown in Item 9 of the Basic Lease Provisions. As used herein, “Lease Term” shall mean the Initial Term referred to in Item 9 of the Basic Lease Provisions, subject to any extension of the Initial
Term hereof exercised in accordance with the terms and conditions expressly set forth herein (the “Expiration Date”). Unless Landlord is terminating this Lease prior to the Expiration Date in accordance with the provisions hereof,
Landlord shall not be required to provide notice to Tenant of the Expiration Date. This Lease shall be a binding contractual obligation effective upon execution hereof by Landlord and Tenant, notwithstanding the later commencement of the Initial
Term of this Lease. The terms “Tenant Improvements” and “Substantial Completion” or “Substantially Completed’’ are defined in the attached Exhibit B Work
Letter. “Tenant Delays” consist of those delays defined in Exhibit B. 
 (b) The
Premises will be delivered to Tenant when the Tenant Improvements have been Substantially Completed. If the Commencement Date is delayed or otherwise does not occur on the Estimated Commencement Date, set forth in Item 10 of the Basic
Lease Provisions, this Lease shall not be void or voidable, nor shall Landlord be liable to Tenant for any loss or damage resulting therefrom. If Landlord does not Substantially Complete the Tenant Improvements by the Completion Date, then Tenant,
as Tenant’s sole and exclusive remedy, may terminate this Lease by sending written notice of such termination to Landlord at any time after the Completion Date but prior to the Tenant Improvements being Substantially Completed. The term
“Completion Date” shall mean November 1, 2016; provided, however, the Completion Date shall be postponed one (1) day for each day of Tenant Delay and one (1) day for each day of delay caused by events of Force Majeure. 

(c) Notwithstanding the foregoing, subject to applicable ordinances and building codes governing Tenant’s right to occupy or perform in
the Premises, following the date the Tenant Improvements are Substantially Completed and prior to the Commencement Date and subject to all of the terms and provisions of the Lease (except for the payment of Base Rent and Operating Expenses for the
Premises), Tenant shall be allowed to access the Premises, for the purpose of installing Tenant’s furniture, fixtures, computer equipment, telephone equipment and other routine network connections, provided that Tenant does not thereby
unreasonably interfere with the completion of construction or cause any labor dispute as a result of such installations, and provided further that Tenant does hereby agree to indemnify, defend, and hold Landlord harmless from any loss or damage to
such property, and all liability, loss, or damage arising from any injury to the Project, Building or the property of Landlord, its contractors, subcontractors, or materialmen, and any death or personal injury to any person or persons arising out of
such installations, EVEN IF SUCH LOSS, DAMAGE, LIABILITY, DEATH, OR PERSONAL INJURY WAS CAUSED SOLELY OR IN PART BY LANDLORD’S NEGLIGENCE, BUT NOT TO THE EXTENT CAUSED BY THE GROSS NEGLIGENCE OR WILLFUL MISCONDUCT OF LANDLORD. Any such
occupancy or performance in the Premises shall be in accordance with the provisions governing Alterations in the Lease, and shall be subject to Tenant providing to Landlord satisfactory evidence of insurance for personal injury and property damage
related to such installations and satisfactory payment arrangements with respect to installations permitted hereunder. Delay in putting Tenant in possession of the Premises shall not make Landlord liable for any damages arising therefrom. 

(d) Upon the occurrence of the Commencement Date, Landlord shall prepare and deliver to Tenant, Tenant’s Commencement Letter in the form
of Exhibit E attached hereto (the “Commencement Letter”) which Tenant shall acknowledge (provided that if said notice is not factually correct, then Tenant shall make such changes as are necessary
to make the notice factually correct) by executing a copy and returning it to Landlord. If 

  
 5 

 
Tenant fails to sign and return the Commencement Letter to Landlord within ten (10) business days of its receipt from Landlord, the Commencement Letter as sent by Landlord shall be deemed to
have correctly set forth the Commencement Date and the other matters addressed in the Commencement Letter. Failure of Landlord to send the Commencement Letter shall have no effect on the Commencement Date. 

 

	2.	BASE RENT AND SECURITY DEPOSIT 

 (a) Tenant agrees to pay during each month of the
Lease Term as Base Rent (“Base Rent”) for the Premises the sums shown for such periods in Item 5 of the Basic Lease Provisions, except as otherwise expressly provided herein. 

(b) Except as expressly provided to the contrary herein, Base Rent shall be payable in consecutive monthly installments, in advance, without
demand, deduction or offset, commencing on the Commencement Date and continuing on the first day of each calendar month thereafter until the expiration of the Lease Term. The first full monthly installment of Base Rent and Tenant’s
Proportionate Share of Operating Expenses shall be payable upon Tenant’s execution of this Lease. The obligation of Tenant to pay Rent and other sums to Landlord and the obligations of Landlord under this Lease are independent obligations. If
the Commencement Date is a day other than the first day of a calendar month, or the Lease Term expires on a day other than the last day of a calendar month, then the Rent for such partial month shall be calculated on a per diem basis based on actual
days in such months and paid in advance. When Landlord delivers possession of the Premises to Tenant prior to the Commencement Date, Tenant agrees it shall be bound by and subject to all terms, covenants, conditions and obligations of this Lease
during the period between the date possession is delivered and the Commencement Date, other than the payment of Base Rent, Additional Rent and parking charges, in the same manner as if delivery had occurred on the Commencement Date. 

(c) Within ten (10) business days following the mutual execution and delivery of this Lease, Tenant shall deliver to Landlord a letter of
credit from a United States based bank, reasonably acceptable to Landlord, in the amount of One Hundred Nine Thousand Two Hundred and Thirty One and 20/100 Dollars ($109,231.20) (the “Tenant Letter of Credit”), provided that the
Tenant Letter of Credit is in the same form as the form of letter of credit attached as Exhibit F hereto, or in such other form satisfactory to Landlord, in its sole but reasonable discretion. Landlord hereby
approves Comerica as the issuing bank if selected by Tenant to issue the Tenant Letter of Credit. At a minimum such Tenant Letter of Credit shall provide for the following: (a) it shall terminate no sooner than Termination Date of this Lease,
or, if it shall terminate earlier, the Tenant Letter of Credit shall provide that it will automatically renew during each year of the Lease Term or replaced annually until the Termination Date, unless Landlord (the beneficiary thereof) is notified
in writing by the issuer at least thirty (30) days prior to the expiration date that the Tenant Letter of Credit will not be renewed or replaced; and if Landlord is so notified of such non-renewal/non-replacement and Tenant does not replace the Tenant Letter of Credit on or prior to the date which is thirty (30) days prior to the expiration of the current Tenant Letter of Credit,
Landlord (the beneficiary thereof) shall have the right to draw the full amount of such Tenant Letter of Credit prior to such earlier expiration date, and the amounts so drawn shall be held, applied and disbursed in accordance with the terms of this
Paragraph 2 (c) of the Lease (provided, however, Landlord shall deliver such proceeds to Tenant within ten (10) business days following Tenant’s posting of a new Tenant Letter of Credit which complies with the terms of this
Paragraph 2(c)), (b) it shall be irrevocable, and (c) it shall be transferable to any successor to Landlord’s interest under the Lease and the Project. If at any time during the Lease Term, the bank or financial institution that issues the
letter of credit is declared insolvent, or is placed into receivership by the Federal Deposit Insurance Corporation or any other governmental or quasi-governmental institution, or if there is a material
adverse change in the financial or business condition of the bank or financial institution from the date of the Lease which could threaten the viability of the Tenant Letter of Credit as reasonably determined by Landlord, then following written
notice from Landlord, Tenant shall have thirty (30) days to replace the Tenant Letter of Credit with a new letter of credit from a bank or financial institution reasonably acceptable to Landlord in Landlord’s reasonable discretion (which
approval shall not be unreasonably withheld and shall be granted or denied within 

  
 6 

 
(5) business days). If Tenant does not replace the Tenant Letter of Credit with a new letter of credit from a bank or financial institution acceptable to Landlord within such thirty (30) day
period, then notwithstanding anything in the Lease to the contrary, Tenant shall be in default, and Landlord shall have the right to draw upon the Tenant Letter of Credit for the full amount of the Tenant Letter of Credit, which amount shall be held
and applied as the “Security Deposit” hereunder. 
 If Tenant defaults with respect to any provision of this Lease beyond
applicable notice and cure periods, including, without limitation, the provisions relating to the payment of Rent or the cleaning of the Premises upon the termination of this Lease, or amounts which Landlord may be entitled to recover pursuant to
the provisions of Section 1951.2 of the California Civil Code, Landlord may, but shall not be required to, use, apply or retain all or any part of the Security Deposit (i) for the payment of any Rent or any other sum in default beyond
applicable notice and cure periods, (ii) for the payment of any other amount which Landlord may spend or become obligated to spend by reason of Tenant’s default hereunder beyond applicable notice and cure periods, or (iii) to
compensate Landlord for any other loss or damage which Landlord may suffer by reason of Tenant’s default hereunder beyond applicable notice and cure periods, including, without limitation, costs and reasonable attorneys’ fees incurred by
Landlord to recover possession of the Premises following a default by Tenant hereunder. The use or application of the Security Deposit or any portion thereof shall not prevent Landlord from exercising any other right or remedy provided hereunder or
under any Law and shall not be construed as liquidated damages. In the event Landlord draws down the Letter of Credit pursuant to the terms of this Lease, Landlord shall not be required to keep the proceeds of the Letter of Credit separate from its
general funds and Tenant shall not be entitled to interest thereon. 
 If any portion of the Security Deposit is so used or applied, Tenant
shall, upon demand therefor, deposit cash with Landlord in an amount sufficient to restore the Security Deposit or provide Landlord with a substitute Tenant Letter of Credit in the amount required hereunder within ten (10) business days to the
appropriate amount, as determined hereunder. The Security Deposit or any unapplied balance thereof shall be returned to Tenant (or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder) within thirty (30) days
following the expiration of the Lease Term. Tenant hereby waives the provisions of Section 1950.7 of the California Civil Code. Tenant also waives all provisions of law, now or hereafter in force, which provide that Landlord may claim from a
security deposit only those sums reasonably necessary to remedy defaults in the payment of rent, to repair damage caused by Tenant or to clean the Premises, it being agreed that Landlord may, in addition, claim those sums reasonably necessary to
compensate Landlord for any other loss or damage, foreseeable or unforeseeable, caused by the act or omission of Tenant or any Tenant Affiliates (as defined in Paragraph 6(g)(i) below). 

(d) The parties agree that for all purposes hereunder the Premises shall be stipulated to contain the number of square feet of Rentable Area
described in Item 3 of the Basic Lease Provisions. 
  

	3.	ADDITIONAL RENT 

 (a) If Operating Expenses (defined below) for the Project for
any calendar year during the Lease Term exceed Base Operating Expenses (defined below), Tenant shall pay to Landlord as additional rent (“Additional Rent”) an amount equal to Tenant’s Proportionate Share (defined below) of such
excess in accordance with this Paragraph 3; provided, however, notwithstanding anything to the contrary contained herein, no Operating Expenses shall be due under this Lease during the initial twelve (12) months of the Lease Term. 

(b) “Tenant’s Proportionate Share” is, subject to the provisions of Paragraph 18. the percentage number described
in Item 4 of the Basic Lease Provisions. Tenant’s Proportionate Share represents, subject to the provisions of Paragraph 18, a fraction, the numerator of which is the number of square feet of Rentable Area in the Premises
and the denominator of which is the number of square feet of Rentable Area for lease to third parties in the Project, as determined by Landlord pursuant to Paragraph 18. 

  
 7 

 (c) “Base Operating Expenses” means all Operating Expenses incurred or payable
by Landlord during the calendar year specified as Tenant’s Base Year in Item 8 of the Basic Lease Provisions. 
 (d)
“Operating Expenses” means all costs, expenses and obligations incurred or payable by Landlord in connection with the operation, ownership, management, repair or maintenance of the Building and the Project during or allocable to the
Lease Term, all as determined in accordance with real estate accounting and management practices consistently applied, including without limitation, the following: 

(i) Any form of assessment, license fee, license tax, business license fee, commercial rental tax, levy, charge, improvement
bond, tax, water and sewer rents and charges, utilities and communications taxes and charges or similar or dissimilar imposition imposed by any authority having the direct power to tax, including any city, county, state or federal government, or any
school, agricultural, lighting, drainage or other improvement or special assessment district thereof, or any other governmental charge, general and special, ordinary and extraordinary, foreseen and unforeseen, which may be assessed against any legal
or equitable interest of Landlord in the Premises, Building, Common Areas or Project (collectively, (“Taxes”). Taxes shall also include, without limitation: 

(A) any tax on Landlord’s “right” to rent or “right” to other income from the Premises or as against Landlord’s
business of leasing the Premises; 
 (B) any assessment, tax, fee, levy or charge in substitution, partially or totally, of any assessment,
tax, fee, levy or charge previously included within the definition of real property tax, it being acknowledged by Tenant and Landlord that Proposition 13 was adopted by the voters of the State of California in the June, 1978 election and that
assessments, taxes, fees, levies and charges may be imposed by governmental agencies for such services as fire protection, street, sidewalk and road maintenance, refuse removal and for other governmental services formerly provided without charge to
property owners or occupants. It is the intention of Tenant and Landlord that all such new and increased assessments, taxes, fees, levies and charges be included within the definition of “Taxes” for the purposes of this Lease; 

(C) any assessment, tax, fee, levy or charge allocable to or measured by the area of the Premises or other premises in the Building or the
rent payable by Tenant hereunder or other tenants of the Project, including, without limitation, any gross receipts tax or excise tax levied by state, city or federal government, or any political subdivision thereof, with respect to the receipt of
such rent, or upon or with respect to the possession, leasing, operation, management, maintenance, alteration, repair, use or occupancy by Tenant of the Premises, or any portion thereof but not on Landlord’s other operations; 

(D) any assessment, tax, fee, levy or charge upon this transaction or any document to which Tenant is a party, creating or transferring an
interest or an estate in the Premises; 
 (E) any assessment, tax, fee, levy or charge by any governmental agency related to any
transportation plan, fund or system (including assessment districts) instituted within the geographic area of which the Project is a part; and/or 

(F) any costs and expenses (including, without limitation, reasonable attorneys’ fees) incurred in attempting to protest, reduce or
minimize Taxes. 
 The Taxes for any given calendar year shall be the amount of Taxes due and payable during such calendar year; provided,
that in the case of special assessments which may be paid in installments, only the installment, plus any interest, payable during the calendar year shall be included in Taxes. Landlord shall have the exclusive right to contest, petition for review,
or otherwise seek a reduction in Taxes. Refunds of Taxes shall be credited against Taxes and refunded to Tenant regardless of when received, based on the calendar year to which the refund 

  
 8 

 
is applicable. Notwithstanding anything to the contrary, there shall be excluded from Taxes (i) all excess profits taxes, franchise taxes, gift taxes, capital stock taxes, inheritance and
succession taxes, estate taxes, federal and state income taxes, and other taxes to the extent applicable to Landlord’s general or net income (as opposed to rents, receipts or income attributable to operations at the Project), (ii) any items
paid by Tenant under Paragraph 3(h) of this Lease, (iii) tax penalties, interest or late charges, and (iv) any amounts charged directly to Tenant or other tenants. 

(ii) The cost of services and utilities (including taxes and other charges incurred in connection therewith) provided to the
Premises, the Building or the Project, including, without limitation, water, power, gas, sewer, waste disposal, telephone and cable television facilities, fuel, supplies, equipment, tools, materials, service contracts, janitorial services, waste and
refuse disposal, window cleaning, maintenance and repair of sidewalks and Building exterior and services areas, gardening and landscaping; insurance, including, but not limited to, public liability, fire, property damage, wind, hurricane,
earthquake, terrorism, flood, rental loss, rent continuation, boiler machinery, business interruption, contractual indemnification and All Risk or Causes of Loss - Special Form coverage insurance for up to the
full replacement cost of the Project and such other insurance as is customarily carried by operators of other similar class office buildings in the city in which the Project is located, to the extent carried by Landlord in its discretion, and the
deductible portion of any insured loss otherwise covered by such insurance; the cost of compensation, including employment, welfare and social security taxes, paid vacation days, disability, pension, medical and other fringe benefits of all persons
(including independent contractors) who perform services connected with the operation, maintenance, repair or replacement of the Project; any association assessments, costs, dues and/or expenses relating to the Project, personal property taxes on
and maintenance and repair of equipment and other personal property used in connection with the operation, maintenance or repair of the Project; repair and replacement of window coverings provided by Landlord in the premises of tenants in the
Project; such reasonable auditors’ fees and legal fees as are incurred in connection with the operation, maintenance or repair of the Project; administration fees; a property management fee (which fee may be imputed if Landlord has internalized
management or otherwise acts as its own property manager); the maintenance of any easements or ground leases benefiting the Project, whether by Landlord or by an independent contractor; a reasonable allowance for depreciation of personal property
used in the operation, maintenance or repair of the Project; license, permit and inspection fees; all costs and expenses required by any governmental or quasi-governmental authority or by applicable law
enacted after the Commencement Date, for any reason, including capital expenditures, and the cost of any capital expenditures made to the Project by Landlord that improve life-safety systems or reduce
operating expenses to the extent of reduction reasonably anticipated by Landlord at the time of such expenditure (such costs to be amortized over the useful life of such items together with interest thereon at the rate of eight percent per annum or
such higher rate as may have been paid by Landlord on funds borrowed for the purpose of funding such improvements); the cost of air conditioning, heating, ventilating, plumbing, elevator maintenance and repair (to include the replacement of
components subject to the amortization of capital expenditures as provided above) and other mechanical and electrical systems repair and maintenance; sign maintenance; and Common Area (defined below) repair, resurfacing, operation and maintenance;
the reasonable cost for temporary lobby displays and events commensurate with the operation of a similar class building, and the cost of providing security services, if any, deemed appropriate by Landlord. Landlord shall (i) not make a profit
by charging items to Operating Expenses that are otherwise also charged separately to others, and (ii) Landlord shall not collect Operating Expenses from Tenant and all other tenants/occupants in the Project in an amount in excess of what
Landlord actually incurred for the items included in Operating Expenses. 

  
 9 

 The following items shall be excluded from Operating Expenses: 

(A) leasing commissions, attorneys’ fees, costs and disbursements and other expenses incurred in connection with leasing, renovating or
improving vacant space in the Project for tenants or prospective tenants of the Project; 
 (B) costs (including permit, license and
inspection fees) incurred in renovating or otherwise improving or decorating, painting or redecorating space for tenants or vacant space; 

(C) Landlord’s costs of any services sold to tenants for which Landlord is entitled to be reimbursed by such tenants as an additional
charge or rental over and above the Base Rent and Operating Expenses payable under the lease with such tenant or other occupant; 
 (D) any
depreciation or amortization of the Project except as expressly permitted herein; 
 (E) costs incurred due to a violation of Law (defined
below) by Landlord relating to the Project; 
 (F) rent under any ground leases, principal, interest on debt or amortization payments on
any mortgages or deeds of trust or any other debt for borrowed money; 
 (G) all items and services for which Tenant or other tenants
reimburse Landlord outside of Operating Expenses; 
 (H) repairs or other work occasioned by fire, windstorm or other work paid for through
insurance or condemnation proceeds (excluding any deductible); 
 (I) legal expenses incurred for (i) negotiating lease terms for
prospective tenants, (ii) negotiating termination or extension of leases with existing tenants, (iii) proceedings against any other specific tenant relating solely to the collection of rent or other sums due to Landlord from such tenant,
or (iv) the development and/or construction of the Project; 
 (J) repairs resulting from any defect in the original design or
construction of the Project; 
 (K) space planners’ fees, marketing costs, inducements, and advertising and promotional expenses
incurred in connection with the leasing of the Building or the Project; 
 (L) costs for which Landlord is actually reimbursed by
(1) tenants, (ii) insurance from its insurance carrier (or costs for which Landlord would have been reimbursed by insurance carriers had Landlord maintained the insurance required by this Lease but any deductible thereunder shall be an
Operating Expense), any insurance carrier of any tenant, or (iv) from any other third party; 
 (M) any bad debt loss, rent loss, or
reserves for bad debts or rent loss and any reserves of any kind; 
 (N) expenses in connection with services (including separately metered
utilities) or other benefits of a type which are not standard for the Building or the Project, and which are not available to Tenant without specific charges therefor, but which are provided to another tenant or occupant of the Building or the
Project whether or not such other tenant or occupant is specifically charged therefor by Landlord; 

  
 10 

 (O) costs associated with the operation of the business of the partnership or entity which
constitutes Landlord, as the same are distinguished from the costs of operation of the Building or the Project, including partnership accounting and legal matters, costs of defending any lawsuits with any mortgagee (except as the actions of Tenant
may be in issue), costs of selling, syndicating, financing, mortgaging or hypothecating any of Landlord’s interest in the Building or the Project, costs of any disputes between Landlord and its employees, disputes of Landlord with Building or
the Project management; 
 (P) the wages and benefits of any employee who does not devote substantially all of his or her employed time to
the Building or the Project shall be allocated as a part of Operating Expenses only to the extent fairly apportioned to the time worked at the Building or the Project, and in no event shall Operating Expenses include wages and/or benefits
attributable to personnel above the level of Project manager; 
 (Q) fines, penalties, late charges and interest on delinquent payments;

 (R) costs incurred due to the violation by Landlord of the terms and conditions of any underlying ground lease pertaining to the
Building or the Project; 
 (S) costs for capital items except for all costs and expenses (i) required by any new (or change in) laws,
rules or regulations of any governmental or quasi-governmental authority which are enacted or made applicable to the Project after the Date of this Lease, (ii) intended to improve life-safety systems, or (iii) to reduce operating expenses, but only to the extent that such operating expenses are actually reduced (collectively, the “Permitted Capital Improvements”); 

(T) any amount paid by Landlord or to the parent organization or a subsidiary or affiliate of the Landlord for supplies and/or services in
the Project to the extent the same exceeds the costs of such supplies and/or services rendered by qualified, first-class unaffiliated third parties on a competitive basis; 

(U) costs of extra or after-hours HVAC, utilities or services which are provided to Tenant and or any
occupant of the Project and as to which Tenant or such other occupants are separately charged; 
 (V) electric power, HVAC or other
utilities costs for which any tenant directly contracts with a public service company and all items and services for which Tenant or any other tenant in the Project actually reimburses Landlord (other than de minimum amounts), or which Landlord
provides selectively to one or more tenants (other than Tenant) without reimbursement; 
 (W) Rentals and other related expenses incurred
in leasing air conditioning systems, elevators or other equipment which if purchased the cost of which would be excluded from Operating Expenses as a capital cost, except equipment not affixed to the Project which is used in providing janitorial or
similar services and, further excepting from this exclusion such equipment rented or leased to remedy or ameliorate an emergency condition in the Project; 

(X) Rent for any office space occupied by Project management personnel to the extent the size or rental rate of such office space exceeds the
size or fair market rental value of office space occupied by management personnel of other similar class office buildings in the Westlake Village area (the “Comparable Buildings”), with adjustment where appropriate for the size of
the applicable project, and if used for the management of other projects as well, such rent shall be equitably pro-rated; 

(Y) Costs incurred to comply with applicable Laws with respect to Hazardous Materials, as defined below (including, without limitation, with
respect to the monitoring, testing and reporting relating thereto) either (i) located on or below the surface of the Project, (ii) involving asbestos or (iii) located in the Project, which was in existence in the Building or on the
Project prior to the Commencement Date; 

  
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 (Z) Costs arising from Landlord’s charitable or political contributions; 

(AA) Fees payable by Landlord for management of the Project in excess of three percent (3%) of Landlord’s gross rental revenues from the
Project for any calendar year or portion thereof (excluding unapplied security deposits and unearned prepaid rent): 
 (BB) Costs arising
from the gross negligence, illegal acts, or willful misconduct by Landlord or the Landlord Parties; and 
 (CC) Insurance deductibles in
excess of customary deductible amounts carried by landlords of the Comparable Buildings; provided, however, that in connection with any insurance deductible amounts included in Operating Expenses as a result of an earthquake, hurricane or wind shall
be amortized into Operating Expenses at the cost and over the term set forth above for capital expenditures. 
 (e) Operating Expenses that
vary with occupancy in the Project for any calendar year during which actual occupancy of the Project is less than ninety-five percent (95%) of the Rentable Area of the Project shall be appropriately adjusted
by employing real estate accounting and management principles, consistently applied, to reflect ninety-five percent (95%) occupancy of the existing Rentable Area of the Project during such period. In
determining Operating Expenses, if any services or utilities are separately charged to tenants of the Project or others, Operating Expenses shall be adjusted by Landlord to reflect the amount of expense which would have been incurred for such
services or utilities on a full time basis for normal Project operating hours. Operating Expenses for the Tenant’s Base Year for Operating Expenses (as defined in Item 8 of the Basic Lease Provisions) shall not include Operating
Expenses attributable to temporary market-wide labor-rate increases and/or utility rate increases due to extraordinary circumstances, including, but not limited to Force
Majeure, conservation surcharges, boycotts, embargoes, or other shortages. In no event shall the components of utilities for any calendar year related to electrical costs be less than the components of electrical costs in the Base Year for Operating
Expenses. In the event (i) the Commencement Date shall be a date other than January 1, (ii) the date fixed for the expiration of the Lease Term shall be a date other than December 31, (iii) of any early termination of this Lease, or
(iv) of any increase or decrease in the size of the Premises, then in each such event, an appropriate adjustment in the application of this Paragraph 3 shall, subject to the provisions of this Lease, be made in an equitable manner to
reflect such event on a basis determined by Landlord to be consistent with the principles underlying the provisions of this Paragraph 3. In addition, Landlord shall have the right, from time to time, to equitably and consistently allocate and
prorate some or all of the Operating Expenses among different tenants and/or different buildings of the Project and/or on a building-by-building basis (the “Cost
Pools”), adjusting Tenant’s Proportionate Share as to each of the separately allocated costs based on the ratio of the Rentable Area of the Premises to the Rentable Area of all of the premises to which such costs are allocated. Such
Cost Pools may include, without limitation, the office space tenants and retail space tenants of the buildings in the Project. 
 (f) Prior
to the commencement of each calendar year of the Lease Term following the Commencement Date, Landlord shall provide Tenant a written estimate which shall state such expenses in reasonable detail of Tenant’s Proportionate Share of excess
Operating Expenses, if any, for the Project for the ensuing year. Tenant shall pay such estimated amount to Landlord in equal monthly installments, in advance on the first day of each month. Within a reasonable period after the end of each calendar
year, Landlord shall furnish Tenant a statement indicating in reasonable detail the excess of Operating Expenses over Base Operating Expenses for such period and the parties shall, within thirty (30) days thereafter, make any payment or
allowance necessary to adjust Tenant’s estimated payments to Tenant’s actual share of such excess as indicated by such annual statement. Any payment due Landlord shall be payable by Tenant within thirty (30) days of demand from
Landlord. Any amount due Tenant shall be credited against installments next becoming due under this Paragraph 3(f) or refunded to Tenant, if requested by Tenant. 

  
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 (g) All capital levies or other taxes assessed or imposed on Landlord upon the rents payable to
Landlord under this Lease and any excise, transaction, sales or privilege tax, assessment, levy or charge measured by or based, in whole or in part, upon such rents from the Premises and/or the Project or any portion thereof shall be paid by Tenant
to Landlord monthly in estimated installments or within thirty (30) days of demand, at the option of Landlord, as additional rent to be allocated to monthly Operating Expenses. 

(h) Tenant shall pay ten (10) days before delinquency, all taxes and assessments (i) levied against any personal property,
Alterations, tenant improvements or trade fixtures of Tenant in or about the Premises, (ii) based upon this Lease or any document to which Tenant is a party creating or transferring an interest in this Lease or an estate in all or any portion
of the Premises, and (iii) levied for any business, professional, or occupational license fees relating to Tenant or Tenant’s permitted use of the Premises. If any such taxes or assessments are levied against Landlord or Landlord’s
property or if the assessed value of the Project is increased by the inclusion therein of a value placed upon such personal property or trade fixtures, Tenant shall within thirty (30) days of demand reimburse Landlord for the taxes and
assessments so levied against Landlord, or such taxes, levies and assessments resulting from such increase in assessed value. To the extent that any such taxes are not separately assessed or billed to Tenant, Tenant shall pay the amount thereof as
invoiced to Tenant by Landlord within thirty (30) days thereof. In the event that the Project is owned by an entity the property of which is exempt from taxation pursuant to the California Revenue and Taxation Code, Tenant’s possessory
interest may be subject to property taxation pursuant to Section 107.6 of the California Revenue and Taxation Code and to the payment of property taxes levied on that interest in excess of the amount that should have been included in the Base
Year for Operating Expenses. The full cash value, as defined in Sections 110 and 110.1 of the California Revenue and Taxation Code, of the possessory interest, upon which property taxes will be based, shall equal the greater of (A) the full
cash value of the possessory interest or (B) if Tenant has leased less than all of the Project, Tenant’s allocable share of the full cash value of the Project that would have been enrolled if the Project had been subject to property tax
upon acquisition by Landlord. The full cash value as provided for pursuant to either (A) or (B) of the preceding sentence shall reflect the anticipated term of possession if, on the lien date described in Section 2192 of the California
Revenue and Taxation Code, that term is expected to terminate prior to the end of the next succeeding fiscal year. Tenant’s allocable share shall, subject to the preceding sentence, be the Rentable Area of the Premises divided by the Rentable
Area of the Project, but in all cases, in excess of the amount that should have been included in the Base Year for Operating Expenses. 

(i) Any delay or failure of Landlord in (i) delivering any estimate or statement described in this Paragraph 3, or
(ii) computing or billing Tenant’s Proportionate Share of excess Operating Expenses shall not constitute a waiver of its right to require an increase in Rent, or in any way impair the continuing obligations of Tenant under this
Paragraph 3. In the event of any dispute as to any Additional Rent due under this Paragraph 3, Tenant, an officer of Tenant or Tenant’s certified public accountant (but (a) in no event shall Tenant hire or employ an
accounting firm or any other person to audit Landlord as set forth under this Paragraph who is compensated or paid for such audit on a contingency basis and (b) in the event Tenant hires or employs an independent party to perform such audit,
Tenant shall provide Landlord with a copy of the engagement letter) shall have the right after reasonable notice and at reasonable times to inspect Landlord’s accounting records and appropriate back-up at
Landlord’s accounting office. If, after such inspection, Tenant still disputes such Additional Rent, upon Tenant’s written request therefor, a certification as to the proper amount of Operating Expenses and the amount due to or payable by
Tenant shall be made by an independent certified public accountant mutually agreed to by Landlord and Tenant. If Landlord and Tenant cannot mutually agree to an independent certified public accountant, then the parties agree that Landlord shall
choose an independent certified public accountant to conduct the certification as to the proper amount of Tenant’s Proportionate Share of Operating Expenses due by Tenant for the period in question; provided, however, such certified public
accountant shall not be the accountant who conducted Landlord’s initial calculation of Operating Expenses to which Tenant is now objecting. Such certification shall be final and conclusive as to all parties. If the certification reflects that
Tenant has overpaid Tenant’s Proportionate Share of Operating Expenses for the period in question, then Landlord shall credit such excess to Tenant’s next payment of Operating Expenses or, at the request of Tenant,

  
 13 

 
promptly refund such excess to Tenant and conversely, if Tenant has underpaid Tenant’s Proportionate Share of Operating Expenses, Tenant shall pay such additional Operating Expenses to
Landlord within thirty (30) days of notice. Tenant agrees to pay the cost of such certification and the investigation with respect thereto unless it is determined that Landlord’s original statement was in error in Landlord’s favor by
more than five percent (5%), in which event Landlord shall pay and/or reimburse Tenant, as appropriately for all such costs up to a maximum amount of $5,000.00. Tenant waives the right to dispute any matter relating to the calculation of Operating
Expenses or Additional Rent under this Paragraph 3 if any claim or dispute is not asserted in writing to Landlord within one hundred eighty (180) days after delivery to Tenant of the original billing statement with respect thereto;
provided, that in the event Landlord fails to make its accounting records for the applicable calendar year reasonably available for such purpose in accordance with the terms of this Paragraph 3(i), then such one hundred eighty (180) day audit
period shall be extended one (1) day for each day that Tenant and/or Tenant’s auditor, as the case may be, is so prevented from accessing such accounting records. Notwithstanding the foregoing, Tenant shall maintain strict confidentiality
of all of Landlord’s accounting records and shall not disclose the same to any other person or entity except for Tenant’s professional advisory representatives (such as Tenant’s employees, accountants, advisors, attorneys and
consultants) with a need to know such accounting information, who agree to similarly maintain the confidentiality of such financial information. 

(j) Even though the Lease Term has expired and Tenant has vacated the Premises, when the final determination is made of Tenant’s
Proportionate Share of excess Operating Expenses for the year in which this Lease terminates, Tenant shall immediately pay any increase due over the estimated Operating Expenses paid, and conversely, any overpayment made by Tenant shall be promptly
refunded to Tenant by Landlord. 
 (k) The Base Rent, Additional Rent, late fees, and other amounts required to be paid by Tenant to
Landlord hereunder (including the excess Operating Expenses) are sometimes collectively referred to as, and shall constitute, “Rent”. 
  

	4.	IMPROVEMENTS AND ALTERATIONS 

 (a) Except as expressly provided otherwise in this
Lease, including without limitation, Exhibit B, latent defects and Landlord’s on-going repair and maintenance obligations. Landlord shall deliver the Premises to Tenant,
and Tenant agrees to accept the Premises from Landlord in its existing “AS-IS”, “WHERE-IS” and “WITH ALL FAULTS” condition, and Landlord
shall have no obligation to refurbish or otherwise improve the Premises throughout the Lease Term; provided, however, and notwithstanding the foregoing to the contrary, Landlord’s sole construction obligation under this Lease with respect to
the initial Tenant Improvements is set forth in the Work Letter attached hereto as Exhibit B. 

(b) Any alterations, additions, or improvements made by or on behalf of Tenant to the Premises (“Alterations”) shall be
subject to Landlord’s prior written consent. Landlord’s consent shall not be unreasonably withheld with respect to proposed Alterations that (i) comply with all applicable laws, ordinances, rules and regulations; (ii) are
compatible with the Building and its mechanical, electrical, HVAC and life safety systems; (iii) will not interfere with the use and occupancy of any other portion of the Building by any other tenant or their invitees; (iv) do not affect
the structural portions of the Building; and, (v) do not and will not, whether alone or taken together with other improvements, require the construction of any other improvements or alterations within the Building. Tenant shall also have the
right without Landlord’s consent or prior notice to Landlord to install phone, computer and telecommunications lines and cabling that do not materially affect the Building systems and are located entirely within the Premises. Tenant shall
cause, at its sole cost and expense, all Alterations to comply with commercially reasonable insurance requirements and with Laws and shall construct, at its sole cost and expense, any alteration or modification required in the Premises by Laws as a
result of any Alterations and any Alterations required outside the Premises shall be performed by Landlord and included in Operating Expenses. All Alterations shall be constructed at Tenant’s sole cost and expense, in a first class and good and
workmanlike manner by contractors reasonably acceptable to Landlord and only good grades of materials shall be used. All 

  
 14 

 
plans and specifications for any Alterations shall be submitted to Landlord for its approval, which approval shall not be unreasonably withheld and shall be granted or denied within a reasonable
period of time, but no later than thirty (30) days after Landlord’s receipt of such written request. Landlord may monitor construction of the Alterations and Tenant shall reimburse Landlord for any out-of-pocket costs incurred by Landlord in monitoring such construction. Landlord’s right to review plans and specifications and to monitor construction shall be solely for its own benefit, and Landlord
shall have no duty to see that such plans and specifications or construction comply with applicable laws, codes, rules and regulations. Without limiting the other grounds upon which Landlord may refuse to approve any contractor or subcontractor,
Landlord may take into account the desirability of maintaining harmonious labor relations at the Project. Landlord may also require that all life safety related work and all mechanical, electrical, plumbing and roof related work be performed by
contractors designated by Landlord, so long as such contractors are reasonably available and competitively priced. Landlord shall have the right, in its sole discretion, to instruct Tenant to remove those
non-general office improvements or non-general office Alterations from the Premises which (i) were not approved in advance by Landlord, (ii) were not built in
conformance with the plans and specifications approved by Landlord, or (iii) Landlord specified during its review of plans and specifications for Alterations would need to be removed by Tenant upon the expiration of this Lease. Except as set
forth in the proceeding sentence, Tenant shall not be obligated to remove such Alterations at the expiration of this Lease and Tenant shall not be obligated to remove any Tenant Improvements made by Landlord. Landlord shall not unreasonably withhold
or delay its approval with respect to what improvements or Alterations Landlord may require Tenant to remove at the expiration of the Lease. If Landlord concurrently with Landlord’s consent requires Tenant to remove any or all of such
Alterations from the Premises upon the termination of this Lease, then Tenant, at Tenant’s sole cost and expense, shall promptly remove such Alterations and improvements and Tenant shall repair and restore the Premises to its original condition
as of the Commencement Date, reasonable wear and tear excepted. Any Alterations remaining in the Premises following the expiration of the Lease Term or following the surrender of the Premises from Tenant to Landlord, shall become the property of
Landlord unless Landlord notifies Tenant otherwise. Tenant shall provide Landlord with the identities and mailing addresses of all persons performing work or supplying materials, prior to beginning such construction, and Landlord may post on and
about the Premises notices of non-responsibility pursuant to applicable law. Tenant shall assure payment for the completion of all work free and clear of liens and shall provide certificates of insurance for
worker’s compensation and other coverage in amounts and from an insurance company reasonably satisfactory to Landlord protecting Landlord against liability for bodily injury or property damage during construction. Upon completion of any
Alterations and upon Landlord’s reasonable request, Tenant shall deliver to Landlord sworn statements setting forth the names of all contractors and subcontractors who did work on the Alterations and final lien waivers from all such contractors
and subcontractors. Additionally, upon completion of any Alteration, Tenant shall provide Landlord, at Tenant’s expense, with a complete set of plans in reproducible form and specifications reflecting the actual conditions of the Alterations,
together with a copy of such plans on diskette in the AutoCAD format or such other format as may then be in common use for computer assisted design purposes. Tenant shall pay to Landlord, as additional rent, the reasonable costs of Landlord’s
engineers and other consultants (but not Landlord’s on-site management personnel) for review of all plans, specifications and working drawings for the Alterations and for the incorporation of such
Alterations in the Landlord’s master Building drawings, within thirty (30) days after Tenant’s receipt of invoices either from Landlord or such consultants together with (in any event) an administrative charge of four percent (4%) of
the actual costs of such work. In addition to such costs, Tenant shall pay to Landlord, within thirty (30) business days after completion of any Alterations, the actual, reasonable costs incurred by Landlord for services rendered by
Landlord’s management personnel and engineers to coordinate and/or supervise any of the Alterations to the extent such services are provided in excess of or after the normal on-site hours of such
engineers and management personnel. 
 (c) Tenant shall keep the Premises, the Building and the Project free from any and all liens arising
out of any Alterations, work performed, materials furnished, or obligations incurred by or for Tenant. In the event that Tenant shall not, within ten (10) business days following notice from Landlord of the imposition of any such lien, cause
the same to be released of record by payment or posting of a bond in a form and issued by a surety 

  
 15 

 
acceptable to Landlord, Landlord shall have the right, but not the obligation, to cause such lien to be released by such means as it shall deem proper (including payment of or defense against the
claim giving rise to such lien); in such case, Tenant shall reimburse Landlord for all amounts so paid by Landlord in connection therewith, together with all of Landlord’s costs and expenses, with interest thereon at the Default Rate (defined
below) and Tenant shall indemnify and defend each and all of the Landlord Indemnitees (defined below) against any damages, losses or costs arising out of any such claim. Tenant’s indemnification of Landlord contained in this Paragraph shall
survive the expiration or earlier termination of this Lease. Such rights of Landlord shall be in addition to all other remedies provided herein or by law. 

(d) NOTICE IS HEREBY GIVEN THAT LANDLORD SHALL NOT BE LIABLE FOR ANY LABOR, SERVICES OR MATERIALS FURNISHED OR TO BE FURNISHED TO TENANT, OR
TO ANYONE HOLDING THE PREMISES THROUGH OR UNDER TENANT, AND THAT NO MECHANICS’ OR OTHER LIENS FOR ANY SUCH LABOR, SERVICES OR MATERIALS SHALL ATTACH TO OR AFFECT THE INTEREST OF LANDLORD IN THE PREMISES. 

 

	5.	REPAIRS 

 (a) Landlord shall maintain in good operating order and keep in good
repair and condition, in a manner consistent with the maintenance and operations standards employed by landlords of Comparable Buildings, as part of Basic Services shall be limited to (i) the structural portions of the Building, (ii) the
exterior walls of the Building, including, without limitation, glass and glazing, (iii) the roof, (iv) mechanical, electrical, plumbing, sprinkler, HVAC and life safety systems except for any lavatory, shower, toilet, wash basin and
kitchen facilities that serve Tenant exclusively and were not part of the base Building core infrastructure and any supplemental heating and air conditioning systems (including all plumbing connected to said facilities or systems located in the
Premises), and (v) Common Areas. Landlord shall not be deemed to have breached any obligation with respect to the condition of any part of the Project unless Tenant has given to Landlord written notice of any required repair and Landlord has
not made such repair within a reasonable time following the receipt by Landlord of such notice. The foregoing notwithstanding: (i) Landlord shall not be required to repair damage to any of the foregoing to the extent caused by the negligence or
willful misconduct of Tenant or it agents, employees or contractors, except to the extent covered by insurance carried by Landlord; and (ii) the obligations of Landlord pertaining to damage or destruction by casualty shall be governed by the
provisions of Paragraph 9. Landlord shall have the right but not the obligation to undertake work of repair that Tenant is required to perform under this Lease and that Tenant fails or refuses to perform in a timely and efficient manner. All
costs incurred by Landlord in performing any such repair for the account of Tenant shall be repaid by Tenant to Landlord within thirty (30) days of demand, together with an administration fee equal to ten percent (10%) of such costs. Except as
expressly provided in Paragraphs 9 and 12 of this Lease, there shall be no abatement of Rent and no liability of Landlord by reason of any injury to or interference with Tenant’s business arising from the making of any repairs,
alterations or improvements in or to any portion of the Premises, the Building or the Project. Tenant waives the right to make repairs at Landlord’s expense under any law, statute or ordinance now or hereafter in effect (including the
provisions of California Civil Code Section 1942 and any successive sections or statutes of a similar nature). 
 (b) Tenant, at its
expense, (i) shall keep the non-structural, interior portions of the Premises and all fixtures contained therein in a safe, clean and neat condition, and (ii) shall bear the cost of maintenance and
repair, by contractors reasonably approved by Landlord, of all facilities which are not expressly required to be maintained or repaired by Landlord and which are located in the Premises, including, without limitation, lavatory, shower, toilet, wash
basin and kitchen facilities, and supplemental heating and air conditioning systems (including all plumbing in the Premises connected to said facilities or systems installed by or on behalf of Tenant or existing in the Premises at the time of
Landlord’s delivery of the Premises to Tenant and were not part of the base Building core infrastructure). Tenant shall make all repairs to the Premises not required to be made by Landlord under subparagraph (a) above with
replacements of any materials to be made by use of materials of equal or better quality. Tenant shall do all decorating, remodeling, alteration and painting required by Tenant during the Lease 

  
 16 

 
Term. To the extent not covered by Landlord’s insurance, Tenant shall pay for the cost of any repairs to the Premises, the Building or the Project made necessary by any negligence or willful
misconduct of Tenant or any of its assignees, subtenants, employees or their respective agents, representatives, contractors, or other persons permitted in or invited to the Premises or the Project by Tenant. If Tenant fails to make such repairs or
replacements within thirty (30) days after written notice from Landlord, Landlord may at its option make such repairs or replacements, and Tenant shall within thirty (30) days of demand pay Landlord for the cost thereof, together with an
administration fee equal to ten percent (10%) of such costs. 
 (c) Upon the expiration or earlier termination of this Lease, Tenant shall
surrender the Premises in a safe, clean and neat condition as when received , normal wear and tear and casualty excepted. Except as otherwise set forth in Paragraph 4(b) of this Lease, Tenant shall remove from the Premises all trade fixtures,
furnishings and other personal property of Tenant and all computer and phone cabling and wiring installed by or on behalf of Tenant, shall repair all damage caused by such removal, and shall restore the Premises to its original condition, as when
received, reasonable wear and tear excepted. In addition to all other rights Landlord may have, in the event Tenant does not so remove any such fixtures, furnishings or personal property, Tenant shall be deemed to have abandoned the same, in which
case Landlord may store or dispose of the same at Tenant’s expense, appropriate the same for itself, and/or sell the same in its discretion. All particles of personal property and all business and trade fixtures, machinery and equipment,
furniture and movable partitions owned by Tenant or installed by Tenant at its expense in the Premises, shall remain the property of Tenant, and may be removed by Tenant at any time during the Lease Term. 

 

	6.	USE OF PREMISES 

 (a) Tenant shall use the Premises only for general office uses
and shall not use the Premises or permit the Premises to be used for any other purpose. Landlord shall have the right to deny its consent to any change in the permitted use of the Premises in its sole and absolute discretion. 

(b) Tenant shall not at any time use or occupy the Premises, or permit any act or omission in or about the Premises in violation of any law,
statute, ordinance or any governmental rule, regulation or order (collectively, “Law” or “Laws”) and Tenant shall, upon written notice from Landlord, discontinue any use of the Premises which is declared by any
governmental authority to be a violation of Law; provided, however, the costs of such compliance shall be governed by Paragraph 4 of this Lease. If any Law shall, by reason of the nature of Tenant’s
non-general office use or occupancy of the Premises, impose any duty upon Tenant or Landlord with respect to (i) modification or other maintenance of the Premises, the Building or the Project, or
(ii) the use, Alteration or occupancy thereof, Tenant shall comply with such Law at Tenant’s sole cost and expense. This Lease shall be subject to and Tenant shall comply with all financing documents encumbering the Building or the Project
and all covenants, conditions and restrictions affecting the Premises, the Building or the Project, including, but not limited to, Tenant’s execution of any subordination agreements requested by a mortgagee (which for purposes of this Lease
includes any lender or grantee under a deed of trust) of the Premises, the Building or the Project. 
 (c) Tenant shall not at anytime use
or occupy the Premises in violation of the certificates of occupancy issued for or restrictive covenants pertaining to the Building or the Premises, and in the event that any architectural control committee or department of the state or the city or
county in which the Project is located shall at any time contend or declare that the Premises are used or occupied in violation of such certificate or certificates of occupancy or restrictive covenants, Tenant shall, upon five (5) days’
notice from Landlord or any such governmental agency, immediately discontinue such use of the Premises (and otherwise remedy such violation). The failure by Tenant to discontinue such use shall be considered a default under this Lease and Landlord
shall have the right to exercise any and all rights and remedies provided herein or by Law. Any statement in this Lease of the nature of the business to be conducted by Tenant in the Premises shall not be deemed or construed to constitute a
representation or guaranty by Landlord that such business is or will continue to be lawful or permissible under any certificate of occupancy issued for the Building or the Premises, or otherwise permitted by Law. 

  
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 (d) Tenant shall not do or permit to be done anything which may invalidate or increase the cost
of any fire, All Risk, Causes of Loss - Special Form or other insurance policy covering the Building, the Project and/or property located therein and shall comply with all rules, orders, regulations and
requirements of the appropriate fire codes and ordinances or any other organization performing a similar function. In addition to all other remedies of Landlord, Landlord may require Tenant, within thirty (30) days of demand, to reimburse
Landlord for the full amount of any additional premiums charged for such policy or policies by reason of Tenant’s failure to comply with the provisions of this Paragraph 6. 

(e) Tenant shall not in any way interfere with the rights or quiet enjoyment of other tenants or occupants of the Premises, the Building or
the Project. Tenant shall not use or allow the Premises to be used for any unlawful or objectionable purpose, nor shall Tenant cause, maintain, or permit any nuisance in, on or about the Premises, the Building or the Project. Tenant shall not place
weight upon any portion of the Premises exceeding the structural floor load (per square foot of area) which such area was designated (and is permitted by Law) to carry or otherwise use any Building system in excess of its capacity or in any other
manner which may damage such system or the Building. Tenant shall not create within the Premises a working environment with a density of greater than the lesser of (i) five (5) persons per 1,000 square feet of Rentable Area, or (ii) the
maximum density permitted by Law. Business machines and mechanical equipment shall be placed and maintained by Tenant, at Tenant’s expense, in locations and in settings sufficient in Landlord’s reasonable judgment to absorb and prevent
vibration, noise and annoyance. Tenant shall not commit or suffer to be committed any waste in, on, upon or about the Premises, the Building or the Project. 

(f) Tenant shall take all reasonable steps necessary to adequately secure the Premises from unlawful intrusion, theft, fire and other hazards,
and shall keep and maintain any and all security devices in or on the Premises in good working order, including, but not limited to, exterior door locks for the Premises and smoke detectors and burglar alarms located within the Premises and shall
cooperate with Landlord and other tenants in the Project with respect to access control and other safety matters. 
 (g) As used herein, the
term “Hazardous Material” means any (a) oil or any other petroleum-based substance, flammable substances, explosives, radioactive materials, hazardous wastes or substances, toxic wastes
or substances or any other wastes, materials or pollutants which (i) pose a hazard to the Project or to persons on or about the Project or (ii) cause the Project to be in violation of any Laws; (b) asbestos in any form, urea
formaldehyde foam insulation, transformers or other equipment that contain dielectric fluid containing levels of polychlorinated biphenyls, or radon gas; (c) chemical, material or substance defined as or included in the definition of
“hazardous substances”, “hazardous wastes”, “hazardous materials”, “extremely hazardous waste”, “restricted hazardous waste”, or “toxic substances” or words of similar import under any
applicable local, state or federal law or under the regulations adopted or publications promulgated pursuant thereto, including, but not limited to, the Comprehensive Environmental Response, Compensation and Liability Act of 1980, as amended, 42
U.S.C. §9601, et seq.; the Hazardous Materials Transportation Act, as amended, 49 U.S.C. §1801, et seq.; the Federal Water Pollution Control Act, as amended, 33 U.S.C. §1251, et seq.; the Resource Conservation and Recovery Act, as
amended, 42 U.S.C. §6901, et seq.; the Safe Drinking Water Act, as amended, 42 U.S.C. §300, et seq.; the Toxic Substances Control Act, as amended, 15 U.S.C §2601, et seq.; the Federal Hazardous Substances Control Act, as amended, 15
U.S.C. §1261, et seq.; and the Occupational Safety and Health Act, as amended, 29 U.S.C. §651, et seq.; Sections 25115, 25117, 25122.7, 25140, 25249.8, 25281, 25316, 25501, and 25316 of the California Health and Safety Code; (d) other
chemical, material or substance, exposure to which is prohibited, limited or regulated by any governmental authority or may or could pose a hazard to the health and safety of the occupants of the Project or the owners and/or occupants of property
adjacent to or surrounding the Project, or any other Person coming upon the Project or adjacent property; and (e) other chemicals, materials or substances which may or could pose a hazard to the environment. The term “Permitted
Hazardous Materials” 

  
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shall mean Hazardous Materials which are contained in ordinary office supplies of a type and in quantities typically used in the ordinary course of business within executive offices of similar
size in the comparable office buildings, but only if and to the extent that such supplies are transported, stored and used in full compliance with all applicable laws, ordinances, orders, rules and regulations and otherwise in a safe and prudent
manner. Hazardous Materials which are contained in ordinary office supplies but which are transported, stored and used in a manner which is not in full compliance with all applicable laws, ordinances, orders, rules and regulations or which is not in
any respect safe and prudent shall not be deemed to be “Permitted Hazardous Materials” for the purposes of this Lease. 

(i) Tenant, its assignees, subtenants, and their respective agents, servants, employees, representatives and contractors
(collectively referred to herein as “Tenant Affiliates”) shall not cause or permit any Hazardous Material to be brought upon, kept or used in or about the Premises by Tenant or by Tenant Affiliates without the prior written consent
of Landlord (which may be granted, conditioned or withheld in the sole discretion of Landlord), save and except only for Permitted Hazardous Materials, which Tenant or Tenant Affiliates may bring, store and use in reasonable quantities for their
intended use in the Premises, but only in full compliance with all applicable laws, ordinances, orders, rules and regulations. On or before the expiration or earlier termination of this Lease, Tenant shall remove from the Premises all Hazardous
Materials (including, without limitation, Permitted Hazardous Materials), regardless of whether such Hazardous Materials are present in concentrations which require removal under applicable laws, except to the extent that such Hazardous Materials
were present in the Premises as of the Commencement Date and were not brought onto the Premises by Tenant or Tenant Affiliates. 

(ii) Tenant agrees to indemnify, defend and hold Landlord and its Affiliates (defined below) harmless for, from and against any
and all claims, actions, administrative proceedings (including informal proceedings), judgments, damages, punitive damages, penalties, fines, costs, liabilities, interest or losses, including reasonable attorneys’ fees and expenses, court
costs, consultant fees, and expert fees, together with all other costs and expenses of any kind or nature that arise during or after the Lease Term directly or indirectly from or in connection with the presence, suspected presence, or release of any
Hazardous Material in or into the air, soil, surface water or groundwater at, on, about, under or within the Premises, or any portion thereof caused by Tenant or Tenant Affiliates. 

(iii) In the event any investigation or monitoring of site conditions or any clean-up,
containment, restoration, removal or other remedial work (collectively, the “Remedial Work”) is required under any applicable federal, state or local Law, by any judicial order, or by any governmental entity as the result of
operations or activities upon, or any use or occupancy of any portion of the Premises by Tenant or Tenant Affiliates, Landlord shall perform or cause to be performed the Remedial Work in compliance with such Law or order at Tenant’s sole cost
and expense. All Remedial Work shall be performed by one or more contractors, selected and approved by Landlord, and under the supervision of a consulting engineer, selected by Tenant and approved in advance in writing by Landlord. All costs and
expenses of such Remedial Work shall be paid by Tenant, including, without limitation, the charges of such contractor(s), the consulting engineer, and Landlord’s reasonable attorneys’ fees and costs incurred in connection with monitoring
or review of such Remedial Work. 
 (iv) Each of the covenants and agreements of Tenant set forth in this Paragraph
6(g) shall survive the expiration or earlier termination of this Lease. 
  

	7.	UTILITIES AND SERVICES 

 (a) Landlord shall manage and operate the Project in a first-class manner consistent with Comparable Buildings and shall furnish, or cause to be furnished to the Premises and Common Areas at all times 24 hours per day, 7 days per week) except as otherwise set forth in
this Lease, the utilities and services described in this Paragraph 7(a) (collectively the “Basic Services”): 

(i) Tepid water at those points of supply provided on the floor of the Premises for general use of other tenants in the
Project; 

  
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 (ii) During Business Hours, excluding Holidays, central heat and air conditioning
in season, at such temperatures and in such amounts as are necessary for normal comfort for normal office use or as may be permitted or controlled by applicable laws, ordinances, rules and regulations; 

(iii) Routine maintenance, repairs, structural and exterior maintenance (including, without limitation, exterior glass and
glazing), painting and electric lighting service for all Common Areas and all base Building infrastructure and systems and equipment of the Project in the manner and to the extent deemed by Landlord to be standard, subject to the limitation
contained in Paragraph 5(a) above; 
 (iv) Janitorial service consistent with services provided by Comparable
Buildings on a five (5) day week basis, excluding Holidays, such current janitorial specifications being set forth on Exhibit G hereto. 

(v) An electrical system to convey power delivered by public utility providers selected by Landlord, but not to exceed a total
allowance of five (5) watts per square foot of Rentable Area calculated based on Business Hours on an annualized basis (which includes an allowance for lighting of the Premises at the maximum wattage per square foot of Rentable Area permitted
under applicable laws, ordinances, orders, rules and regulations but excludes the Building heat, ventilation and air conditioning system and elevators); 

(vi) Public elevator service at all times and a freight elevator serving the floors on which the Premises are situated, during
hours designated by Landlord; 
 (vii) Landlord shall provide Tenant with appropriate contact information for Project
personnel that Tenant may contact in the event of an emergency at the Premises or Building twenty-four (24) hours per day, seven (7) days per week (whether or not during Building Hours); and 

(b) Landlord shall provide to Tenant at Tenant’s sole cost and expense (and subject to the limitations hereinafter set forth) the
following extra services (collectively the “Extra Services”): 
 (i) Such extra cleaning and janitorial
services requested by Tenant, and agreed to Landlord, for special improvements or Alterations; 
 (ii) Subject to
Paragraph 7(d) below, additional air conditioning and ventilating required by reason of any electrical, data processing or other equipment or facilities or services required support the same, in excess of that typically provided by the
Building; 
 (iii) Maintaining and replacing non-Building standard lamps, bulbs, and
ballast: 
 (iv) Heating, ventilation or air-conditioning provided by Landlord to
Tenant (i) during hours other than Business Hours, (ii) on Saturdays (after Business Hours), Sundays, or Holidays, said heating, ventilation and air conditioning to be furnished solely upon the prior written request of Tenant given with
such advance notice as Landlord may reasonably require and Tenant shall pay to Landlord $45/hour/zone for the initial Term; 

  
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 (v) Any Basic Service in amounts reasonably determined by Landlord to exceed the
amounts required to be provided above, but only if Landlord elects to provide such additional or excess service. Tenant shall pay Landlord the cost of providing such additional services (or an amount equal to Landlord’s reasonable estimate of
such cost, if the actual cost is not readily ascertainable) together with an administration fee equal to five percent (5%) of such cost, within thirty (30) days following presentation of an invoice therefore by Landlord to Tenant. The cost
chargeable to Tenant for all extra services shall constitute Additional Rent; and 
 (vi) Upon Landlord’s reasonable
approval in writing, Tenant and its telecommunication providers shall have access to the MPOE in the Building for connecting, set-up and installation of Tenant’s telecommunication cabling. 

(c) Tenant agrees to cooperate fully at all times with Landlord and to comply with all reasonable
non-discriminatory regulations and requirements which Landlord may from time to time prescribe for the use of the utilities and Basic Services described herein. Landlord shall not be liable to Tenant for the
failure of any other tenant, or its assignees, subtenants, employees, or their respective invitees, licensees, agents or other representatives to comply with such regulations and requirements, provided Landlord shall use commercially reasonable
efforts to enforce any non-performance of the rules and regulations against the other occupants and tenants of the Project, to the extent such non-performance has an
adverse effect on Tenant’s use of the Premises. The term “Business Hours” shall be deemed to be Monday through Friday from 8:00 A.M. to 6:00 P.M. and Saturday from 9:00 A.M. to 1:00 P.M., excepting Holidays. The term
“Holidays” shall be deemed to mean and include New Year’s Day, Memorial Day, Independence Day, Labor Day, Thanksgiving Day and Christmas Day. Tenant shall have the right, at its sole cost and expense, to install supplemental
HVAC systems for the purpose of providing supplemental air-conditioning to the Premises (the “Tenant HVAC System”) in accordance with the terms of Paragraph 4 above. All aspects of the Tenant HVAC
System shall be subject to Landlord’s prior written approval, which approval shall not be unreasonably withheld, conditioned or delayed. 

(d) If Tenant requires utilities or services in quantities greater than or at times other than that required to be furnished by Landlord as
set forth above, Tenant shall pay to Landlord, within thirty (30) days of receipt of a written statement therefor, Landlord’s actual cost for such use. In the event that Tenant shall require additional electric current, water or gas for
use in the Premises and if, in Landlord’s judgment, such excess requirements cannot be furnished unless additional risers, conduits, feeders, switchboards and/or appurtenances are installed in the Building, subject to the conditions stated
below, Landlord shall proceed to install the same at the sole cost of Tenant, payable upon demand in advance. The installation of such facilities shall be conditioned upon Landlord’s consent, and a determination that the installation and use
thereof (i) shall be permitted by applicable Law and insurance regulations, (ii) shall not cause permanent damage or injury to the Building or adversely affect the value of the Building or the Project, and (iii) shall not cause or
create a dangerous or hazardous condition or interfere with or disturb other tenants in the Building. Subject to the foregoing, Landlord shall, upon reasonable prior notice by Tenant, furnish to the Premises additional elevator, heating, air
conditioning and/or cleaning services upon such reasonable terms and conditions as shall be reasonably determined by Landlord, including payment of Landlord’s actual cost therefor. In the case of any additional utilities or services to be
provided hereunder, Landlord may require a switch and metering system to be installed so as to measure the amount of such additional utilities or services. The cost of installation, maintenance and repair thereof shall be paid by Tenant within
thirty (30) days of demand. Notwithstanding the foregoing, Landlord shall have the right to contract with any utility provider it deems appropriate to provide utilities to the Project. 

(e) Except as otherwise expressly provided herein, Landlord shall not be liable for, and Tenant shall not be entitled to, any damages,
abatement or reduction of Rent, or other liability by reason of any failure to furnish any services or utilities described herein for any reason (other than Landlord’s sole negligence or willful misconduct), including, without limitation, when
caused by accident, breakage, water leakage, flooding, repairs, Alterations or other improvements to the Project, strikes, lockouts or other labor disturbances or labor disputes of 

  
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any character, governmental regulation, moratorium or other governmental action, inability to obtain electricity, water or fuel, or any other cause beyond Landlord’s control. Landlord shall
be entitled to cooperate with the energy conservation efforts of governmental agencies or utility suppliers. No such failure, stoppage or interruption of any such utility or service shall be construed as an eviction of Tenant, nor, except as
otherwise expressly provided herein, shall the same relieve Tenant from any obligation to perform any covenant or agreement under this Lease. In the event of any failure, stoppage or interruption thereof, Landlord shall use reasonable and diligent
efforts to attempt to restore all services promptly. No representation is made by Landlord with respect to the adequacy or fitness of the Building’s ventilating, air conditioning or other systems to maintain temperatures as may be required for
the operation of any computer, data processing or other special equipment of Tenant. Tenant hereby waives the provisions of California Civil Code Section 1932(1) or any other applicable existing or future law, ordinance or governmental
regulation permitting the termination of this Lease due to an interruption, failure or inability to provide any services. Notwithstanding anything in this Paragraph 7 to the contrary, if an interruption or cessation of a utility service to the
Premises from a cause within the reasonable control of Landlord results in the Premises being unusable by Tenant for the conduct of Tenant’s business, then Base Rent shall be abated commencing on that date which is five (5) consecutive
business days following the date Tenant delivers written notice to Landlord of such interruption and continuing until either such utility service to the Premises is restored or the Premises is again usable for the conduct of Tenant’s business.
If, however, Tenant reoccupies any portion of the Premises during such abatement period, the Base Rent allocable to such reoccupied portion, based on the proportion that the Rentable Area of such reoccupied portion of the Premises bears to the total
Rentable Area of the Premises, shall be payable by Tenant from the date Tenant reoccupies such portion of the Premises. Such right to abate Base Rent shall be Tenant’s sole and exclusive remedy at law or in equity in the event of an
interruption or cessation of a utility service to the Premises. 
 (f) Landlord reserves the right from time to time to make reasonable and
nondiscriminatory modifications to the above standards for Basic Services and Extra Services so long as the Building Hours and the amounts of utilities supplied to Tenant do not materially decrease, Holidays do not materially increase, and so long
such Basic Services and Extra Services are consistent with services supplied to Comparable Buildings. 
  

	8.	NON-LIABILITY AND INDEMNIFICATION OF LANDLORD; INSURANCE 

(a) To the greatest extent permitted by Law, and except to the extent caused by Landlord’s or its Affiliates’ negligence or willful
misconduct, Landlord shall not be liable for any injury, loss or damage suffered by Tenant or to any person or property occurring or incurred in or about the Premises, the Building or the Project from any cause. Without limiting the foregoing, to
the greatest extent permitted by law and except to the extent caused by Landlord’s or Landlord Parties’ negligence or willful misconduct, neither Landlord nor any of its partners, officers, trustees, affiliates, directors, employees,
contractors, agents or representatives (collectively, “Affiliates”) shall be liable for and there shall be no abatement of Rent (except in the event of a casualty loss or a condemnation as set forth in Paragraph 9 and
Paragraph 10 of this Lease or as set forth in Paragraph 12) for (i) any damage to Tenant’s property stored with or entrusted to Landlord or Affiliates of Landlord, (ii) loss of or damage to any property by theft or any other
wrongful or illegal act, or (iii) any injury or damage to persons or property resulting from fire, explosion, falling plaster, steam, gas, electricity, water or rain which may leak from any part of the Building or the Project or from the pipes,
appliances, appurtenances or plumbing works therein or from the roof, street or sub-surface or from any other place or resulting from dampness or any other cause whatsoever or from the acts or omissions of
other tenants, occupants or other visitors to the Building or the Project or from any other cause whatsoever, (iv) any diminution or shutting off of light, air or view by any structure which may be erected on lands adjacent to the Building,
whether within or outside of the Project, or (v) any latent or other defect in the Premises, the Building or the Project. Tenant shall give prompt notice to Landlord in the event of (i) the occurrence of a fire or accident in the Premises
or in the Building, or (ii) the discovery of a defect therein or in the fixtures or equipment thereof. This Paragraph 8(a) shall survive the expiration or earlier termination of this Lease. 

  
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 (b) To the greatest extent permitted by Law and except to the extent caused by Landlord’s or
its Affiliates’ negligence or willful misconduct and subject to Paragraph 8(e) below, Tenant hereby agrees to indemnify, protect, defend and hold harmless Landlord and its designated property management company, and their respective partners,
members, affiliates and subsidiaries, and all of their respective officers, trustees, directors, shareholders, employees, servants, partners, representatives, insurers and agents (collectively, “Landlord Indemnitees”) for, from and
against all liabilities, claims, fines, penalties, costs, damages or injuries to persons, damages to property, losses, liens, causes of action, suits, judgments and expenses (including court costs, attorneys’ fees, expert witness fees and costs
of investigation), of any nature, kind or description of any person or entity, directly or indirectly arising out of, caused by, or resulting from (in whole or part) (1) Tenant’s construction of, or use, occupancy or enjoyment of, the
Premises, (2) any activity, work or other things done, permitted or suffered by Tenant and its agents and employees in or about the Premises, (3) any breach or default in the performance of any of Tenant’s obligations under this
Lease, (4) any act, omission, negligence or willful misconduct of Tenant or any of its agents, contractors, employees, business invitees or licensees, or (5) any damage to Tenant’s property, or the property of Tenant’s agents,
employees, contractors, business invitees or licensees, located in or about the Premises (collectively, “Liabilities”). This Paragraph 8(b) shall survive the expiration or earlier termination of this Lease. 

(c) Tenant shall promptly advise Landlord in writing of any action, administrative or legal proceeding or investigation as to which this
indemnification may apply, and Tenant, at Tenant’s expense, shall assume on behalf of each and every Landlord Indemnitee and conduct with due diligence and in good faith the defense thereof with counsel reasonably satisfactory to Landlord;
provided, however, that any Landlord Indemnitee shall have the right, at its option, to be represented therein by advisory counsel of its own selection and at its own expense. In the event of failure by Tenant to fully perform in accordance with
this Paragraph within applicable notice and cure periods, Landlord, at its option, and without relieving Tenant of its obligations hereunder, may so perform, but all costs and expenses so incurred by Landlord in that event shall be reimbursed by
Tenant to Landlord, together with interest on the same from the date any such expense was paid by Landlord until reimbursed by Tenant, at the rate of interest provided to be paid on judgments, by the law of the jurisdiction to which the
interpretation of this Lease is subject. The indemnification provided in Paragraph 8(b) shall not be limited to damages, compensation or benefits payable under insurance policies, workers’ compensation acts, disability benefit acts or
other employees’ benefit acts. 
 (d) Insurance. 

(i) Tenant at all times during the Lease Term shall, at its own expense, keep in full force and effect (A) commercial
general liability insurance providing coverage against bodily injury and disease, including death resulting therefrom and property damage to a combined single limit of $3,000,000 to one or more than one person as the result of any one accident or
occurrence, which shall include provision for contractual liability coverage insuring Tenant for the performance of its indemnity obligations set forth in this Paragraph 8 and in Paragraph 6(g)(ii) of this Lease (to the extent covered
by a standard CGL Policy), which amount may be satisfied through a combination of commercial general liability insurance and an Excess Limits (Umbrella) Policy, (B) worker’s compensation insurance to the statutory limit, if any, and
employer’s liability insurance to the limit of $500,000 per occurrence, and (C) Special Form property insurance, including fire and extended coverage, sprinkler leakage (including sprinkler leakage), vandalism, malicious mischief, wind
and/or hurricane coverage covering full replacement value of all of Tenant’s personal property, trade fixtures and improvements in the Premises. Landlord and its designated property management firm shall be named an additional insured on each
of said policies (excluding the worker’s compensation policy and any property covered other than to improvements to the Premises) and said policies shall be issued by an insurance company or companies authorized to do business in the State and
which have policyholder ratings not lower than “A-” and financial ratings not lower than “VII” in Best’s Insurance Guide (latest edition in effect as of the Effective Date and
subsequently in effect as of the date of renewal of the required policies). EACH OF SAID POLICIES SHALL ALSO INCLUDE A 

  
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WAIVER OF SUBROGATION PROVISION. Tenant hereby waives its right of recovery against any Landlord Indemnitee of any amounts paid by Tenant or on Tenant’s behalf to satisfy applicable
worker’s compensation laws. Certificates showing the material terms for the same, together with satisfactory evidence of the payment of the premiums therefor, shall be deposited with Landlord on the date Tenant first occupies the Premises and
upon renewals of such policies not less than fifteen (15) days prior to the expiration of the term of such coverage. If certificates are supplied rather than the policies themselves, Tenant shall allow Landlord, at all reasonable times, to
inspect the policies of insurance required herein. Landlord and Tenant acknowledge that Tenant shall have the right to cover its insurance requirements set forth in this Paragraph 8(d) with a blanket policy and a combination of general liability and
umbrella insurance coverages, provided that the amounts (based upon the general liability policy and the allocations of the umbrella policy) and other conditions required to be satisfied by the terms of this Paragraph 8(d) are satisfied by such
coverages. 
 (ii) It is expressly understood and agreed that the coverages required represent Landlord’s minimum
requirements and such are not to be construed to void or limit Tenant’s obligations contained in this Lease, including without limitation Tenant’s indemnity obligations hereunder. Neither shall (A) the insolvency, bankruptcy or
failure of any insurance company carrying Tenant, (B) the failure of any insurance company to pay claims occurring nor (C) any exclusion from or insufficiency of coverage be held to affect, negate or waive any of Tenant’s indemnity
obligations under this Paragraph 8 and Paragraph 6(g)(ii) or any other provision of this Lease. With respect to insurance coverages, except worker’s compensation, maintained hereunder by Tenant and insurance coverages separately
obtained by Landlord, all insurance coverages afforded by policies of insurance maintained by Tenant shall be primary insurance as such coverages apply to Landlord, and such insurance coverages separately maintained by Landlord shall be excess, and
Tenant shall have its insurance policies so endorsed. The amount of liability insurance under insurance policies maintained by Tenant shall not be reduced by the existence of insurance coverage under policies separately maintained by Landlord.
Tenant shall be solely responsible for any premiums, assessments, penalties, deductible assumptions, retentions, audits, retrospective adjustments or any other kind of payment due under its policies. Tenant shall increase the amounts of insurance or
the insurance coverages as Landlord may reasonably request from time to time, but not in excess of the requirements of prudent landlords or lenders for similar tenants occupying similar premises in the metropolitan area in which the Building is
located. 
 (iii) Tenant’s occupancy of the Premises without delivering the certificates of insurance shall not
constitute a waiver of Tenant’s obligations to provide the required coverages. If Tenant provides to Landlord a certificate that does not evidence the coverages required herein, or that is faulty in any respect, such shall not constitute a
waiver of Tenant’s obligations to provide the proper insurance. 
 (iv) Throughout the Lease Term, Landlord agrees to
maintain (i) fire and extended coverage insurance, and, at Landlord’s option, earthquake damage coverage, terrorism coverage, wind and hurricane coverage, and such additional property insurance coverage as Landlord deems appropriate, on
the insurable portions of Building and the remainder of the Project in an amount not less than the fair replacement value thereof, subject to reasonable deductibles (ii) boiler and machinery insurance amounts and with deductibles that would be
considered standard for similar class office building in the metropolitan area in which the Premises is located, and (iii) commercial general liability insurance with a combined single limit coverage of at least $1,000,000.00 per occurrence.
All such insurance shall be obtained from insurers Landlord reasonably believes to be financially responsible in light of the risks being insured. The premiums for any such insurance shall be a part of Operating Expenses. 

(e) Mutual Waivers of Recovery. Landlord, Tenant, and all parties claiming under them, each mutually release and discharge each other
from responsibility for that portion of any loss or damage paid or reimbursed by an insurer of Landlord or Tenant under any fire, extended coverage or other property insurance 

  
 24 

 
policy maintained by Tenant with respect to its Premises or by Landlord with respect to the Building or the Project (or which would have been paid had the insurance required to be maintained
hereunder been in full force and effect), no matter how caused, including negligence, and each waives any right of recovery from the other including, but not limited to, claims for contribution or indemnity, which might otherwise exist on account
thereof. Any fire, extended coverage or property insurance policy maintained by Tenant with respect to the Premises, or Landlord with respect to the Building or the Project, shall contain, in the case of Tenant’s policies, a waiver of
subrogation provision or endorsement in favor of Landlord, and in the case of Landlord’s policies, a waiver of subrogation provision or endorsement in favor of Tenant, or, in the event that such insurers cannot or shall not include or attach
such waiver of subrogation provision or endorsement, Tenant and Landlord shall obtain the approval and consent of their respective insurers, in writing, to the terms of this Lease. Tenant agrees to indemnify, protect, defend and hold harmless each
and all of the Landlord Indemnitees from and against any claim, suit or cause of action asserted or brought by Tenant’s insurers for, on behalf of, or in the name of Tenant, including, but not limited to, claims for contribution, indemnity or
subrogation, brought in contravention of this paragraph. The mutual releases, discharges and waivers contained in this provision shall apply EVEN IF THE LOSS OR DAMAGE TO WHICH THIS PROVISION APPLIES IS CAUSED SOLELY OR IN PART BY THE NEGLIGENCE OF
LANDLORD OR TENANT. 
 (f) Business Interruption. Landlord shall not be responsible for, and Tenant releases and discharges Landlord
from, and Tenant further waives any right of recovery from Landlord for, any loss for or from business interruption or loss of use of the Premises suffered by Tenant in connection with Tenant’s use or occupancy of the Premises, EVEN IF SUCH
LOSS IS CAUSED SOLELY OR IN PART BY THE NEGLIGENCE OF LANDLORD. 
 (g) Adjustment of Claims. Tenant shall cooperate with Landlord and
Landlord’s insurers in the adjustment of any insurance claim pertaining to the Building or the Project or Landlord’s use thereof. 

(h) Increase in Landlord’s Insurance Costs. Tenant agrees to pay to Landlord any increase in premiums for Landlord’s
insurance policies resulting from Tenant’s non-general office use or occupancy of the Premises. 

(i) Failure to Maintain Insurance. Any failure of Tenant to obtain and maintain the insurance policies and coverages required hereunder
or failure by Tenant to meet any of the insurance requirements of this Lease shall constitute an event of default hereunder subject to applicable notice and cure periods, and such failure shall entitle Landlord to pursue, exercise or obtain any of
the remedies provided for in Paragraph 12(b), and Tenant shall be solely responsible for any loss suffered by Landlord as a result of such failure. In the event of failure by Tenant to maintain the insurance policies and coverages required by
this Lease or to meet any of the insurance requirements of this Lease, Landlord, at its option, and without relieving Tenant of its obligations hereunder, upon five (5) business days’ notice to Tenant, may obtain said insurance policies
and coverages or perform any other insurance obligation of Tenant, but all costs and expenses incurred by Landlord in obtaining such insurance or performing Tenant’s insurance obligations shall be reimbursed by Tenant to Landlord, together with
interest on same from the date any such cost or expense was paid by Landlord until reimbursed by Tenant, at the rate of interest provided to be paid on judgments, by the law of the jurisdiction to which the interpretation of this Lease is subject.

  

	9.	FIRE OR CASUALTY 

 (a) Subject to the provisions of this Paragraph 9. in
the event the Premises, or access thereto, is wholly or partially destroyed by fire or other casualty, Landlord shall (to the extent permitted by Law and covenants, conditions and restrictions then applicable to the Project) rebuild, repair or
restore the Premises and access thereto to substantially the same condition as existing immediately prior to such destruction (excluding Tenant’s Alterations, trade fixtures, equipment and personal property, which Tenant shall be required to
restore) 

  
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and this Lease shall continue in full force and effect. Notwithstanding the foregoing, (i) Landlord’s obligation to rebuild, repair or restore the Premises shall not apply to any
personal property or other items installed or contained in the Premises, and (ii) in the event Landlord elects to terminate this Lease as provided in this Paragraph 9, Landlord shall have no obligation whatsoever to rebuild, repair or restore
the Premises with respect to any material damage or destruction occurring during the last twelve (12) months of the term of this Lease or any extension of the term. 

(b) Landlord may elect to terminate this Lease in any of the following cases of damage or destruction to the Premises, the Building or the
Project: (i) where the cost of rebuilding, repairing and restoring (collectively, “Restoration”-) of the Building or the Project,
would, regardless of the lack of damage to the Premises or access thereto, in the reasonable opinion of Landlord, exceed twenty percent (20%) of the then replacement cost of the Building; (ii) where, in the case of any damage or destruction to
any portion of the Building or the Project by uninsured casualty, the cost of Restoration of the Building or the Project, in the reasonable opinion of Landlord, exceeds $5,000,000; or (iii) where, in the case of any damage or destruction to the
Premises or access thereto by uninsured casualty, the cost of Restoration of the Premises or access thereto, in the reasonable opinion of Landlord, exceeds twenty percent (20%) of the replacement cost of the Premises; (iv) if Landlord has not
obtained appropriate zoning approvals for reconstruction of the Project, Building or Premises; or (v) where any mortgagee or ground lessor requires that insurance proceeds be applied to any outstanding mortgage or ground lease; or
(vi) where there has been material damage or destruction to the Premises during the last twelve (12) months of the Lease Term; provided, however, that if Landlord does not elect to terminate this Lease pursuant to Landlord’s
termination right as provided above, and the repairs cannot, in the reasonable opinion of a licensed architect or contractor reasonably selected by Landlord, be completed within one (1) year after the damage or destruction is discovered. Tenant
may, within thirty (30) days following Landlord’s election to rebuild and/or restore the Premises. Building and/or Project, elect to terminate this Lease by written notice to Landlord effective as of the date specified in the notice, which
date shall not be less than thirty (30) days nor more than ninety (90) days after the date such notice is given by Tenant. Furthermore, if neither Landlord nor Tenant has terminated this Lease, and the repairs are not actually
substantially completed within one (1) year following the date of discovery of the damage, Tenant shall have the right to terminate this Lease until such time as the repairs are substantially complete, by notice to Landlord (the “Damage
Termination Notice”), effective as of a date set forth in the Damage Termination Notice (the “Damage Termination Date”), which Damage Termination Date shall not be less than thirty (30) days nor more than ninety (90) days
following the date of the Damage Termination Notice. In the event that the Premises or Building is destroyed or damaged to any substantial extent during the last twelve (12) months of the Lease Term, then notwithstanding anything contained in
this Paragraph 9, Tenant shall have the option to terminate this Lease by giving written notice to Landlord of the exercise of such option within thirty (30) days after such damage or destruction, in which event this Lease shall cease and
terminate sixty (60) days after the date of such notice and Tenant shall pay the Rent, properly apportioned up to such date of damage. Any such termination shall be made by ninety (90) days’ prior written notice to Tenant given within
sixty (60) days of the date of such damage or destruction. If this Lease is not terminated by Landlord and as the result of any damage or destruction, the Premises, or a portion thereof, are rendered untenantable, the Base Rent shall abate
reasonably during the period of Restoration (based upon the extent to which such damage and Restoration materially interfere with Tenant’s business in the Premises) in proportion to the ratio that the amount of rentable square feet of the
Premises which is unfit for the permitted use bears to the total rentable square feet of the Premises; provided, further, if the Premises is damaged such that the remaining portion thereof is not sufficient to allow Tenant to conduct its business
operations therefrom, Landlord shall allow Tenant a total abatement during a commercially reasonable period of build-out time and a weekend to move-in). This Lease shall
be considered an express agreement governing any case of damage to or destruction of the Premises, the Building or the Project. This Lease sets forth the terms and conditions upon which this Lease may terminate in the event of any damage or
destruction. Accordingly, the parties hereby waive the provisions of California Civil Code Section 1932, Subsection 2, and Section 1933, Subsection 4 (and any successor statutes thereof permitting the parties to terminate this Lease as a
result of any damage or destruction). 

  
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	10.	EMINENT DOMAIN 

 In the event the whole of the Premises, the Building or the
Project shall be taken under the power of eminent domain, or sold to prevent the exercise thereof (collectively, a “Taking”), this Lease shall automatically terminate as of the date of such Taking. In the event a Taking of a portion
of the Project, the Building or the Premises shall, in the reasonable opinion of Landlord, substantially interfere with Landlord’s operation thereof, Landlord may terminate this Lease upon thirty (30) days’ written notice to Tenant
given at any time within sixty (60) days following the date of such Taking. For purposes of this Lease, the date of Taking shall be the earlier of the date of transfer of title resulting from such Taking or the date of transfer of possession
resulting from such Taking. In the event that a portion of the Premises is so taken and this Lease is not terminated, Landlord shall, to the extent of proceeds paid to Landlord as a result of the Taking, with reasonable diligence, use commercially
reasonable efforts to proceed to restore (to the extent permitted by Law and covenants, conditions and restrictions then applicable to the Project) the Premises (other than Tenant’s personal property and fixtures, and above-standard tenant improvements) to a complete, functioning unit. In such case, the Base Rent shall be reduced proportionately based on the portion of the Premises so taken. If all or any portion of the Premises
is the subject of a temporary Taking, this Lease shall remain in full force and effect and Tenant shall continue to perform each of its obligations under this Lease; in such case, Tenant shall be entitled to receive the entire award allocable to the
temporary Taking of the Premises. Except as provided herein, Tenant shall not assert any claim against Landlord or the condemning authority for, and hereby assigns to Landlord, any compensation in connection with any such Taking, and Landlord shall
be entitled to receive the entire amount of any award therefor, without deduction for any estate or interest of Tenant. Nothing contained in this Paragraph 10 shall be deemed to give Landlord any interest in, or prevent Tenant from seeking
any award against the condemning authority for the Taking of personal property, fixtures, above standard tenant improvements of Tenant or for relocation or moving expenses recoverable by Tenant from the condemning authority. This Paragraph 10
shall be Tenant’s sole and exclusive remedy in the event of a Taking. This Lease sets forth the terms and conditions upon which this Lease may terminate in the event of a Taking. Accordingly, the parties waive the provisions of the California
Code of Civil Procedure Section 1265.130 and any successor or similar statutes permitting the parties to terminate this Lease as a result of a Taking. 
  

	11.	ASSIGNMENT AND SUBLETTING 

 (a) Tenant shall not directly or indirectly,
voluntarily or involuntarily, by operation of law or otherwise, assign, sublet, mortgage or otherwise encumber all or any portion of its interest in this Lease or in the Premises or grant any license for any person other than Tenant or its employees
to use or occupy the Premises or any part thereof without obtaining the prior written consent of Landlord, which consent shall not be unreasonably withheld as hereafter provided and shall be granted or denied within a reasonable period of time, but
no later than twenty-one (21) days after Landlord’s receipt of such written request and all information reasonably requested by Landlord. Any such attempted assignment, subletting, license, mortgage,
other encumbrance or other use or occupancy without the consent of Landlord shall, at Landlord’s option, be null and void and of no effect. Any mortgage, or encumbrance of all or any portion of Tenant’s Interest in this Lease or in the
Premises and any grant of a license for any person other than Tenant or its employees to use or occupy the Premises or any part thereof shall be deemed to be an “assignment” of this Lease. In addition, as used in this Paragraph 11,
the term “Tenant” shall also mean any entity that has guaranteed Tenant’s obligations under this Lease, and the restrictions applicable to Tenant contained herein shall also be applicable to such guarantor. 

(b) No assignment or subletting shall relieve Tenant of its obligation to pay the Rent and to perform all of the other obligations to be
performed by Tenant hereunder. The acceptance of Rent by Landlord from any other person shall not be deemed to be a waiver by Landlord of any provision of this Lease or to be a consent to any subletting or assignment. Consent by Landlord to one
subletting or assignment shall not be deemed to constitute a consent to pay other or subsequent attempted subletting or assignment. If Tenant desires at any time to assign this Lease or to sublet the Premises or any portion thereof, it shall first
notify Landlord of its desire to do 

  
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so and shall submit in writing to Landlord all pertinent information relating to the proposed assignee or sublessee, all pertinent information relating to the proposed assignment or sublease (as
opposed to a sale of Tenant), and all such financial information as Landlord may reasonably request concerning the Tenant and proposed assignee or subtenant. Any assignment or sublease shall be expressly subject to the terms and conditions of this
Lease. 
 (c) At any time within ten (10) business days after Landlord’s receipt of the information specified in subparagraph
(b) above, Landlord may by written notice to Tenant elect to terminate this Lease as to the portion of the Premises so proposed to be subleased or assigned (which may include all of the Premises), with a proportionate abatement in the Rent
payable hereunder. 
 (d) Tenant acknowledges that it shall be reasonable for Landlord to withhold its consent to a proposed assignment or
sublease in any of the following instances: 
 (i) The assignee or sublessee is not, in Landlord’s reasonable opinion,
sufficiently creditworthy to perform the obligations such assignee or sublessee will have under this Lease; 
 (ii) The
intended use of the Premises by the assignee or sublessee is not for the permitted use; 
 (iii) Intentionally deleted. 

(iv) Occupancy of the Premises by the assignee or sublessee would, in the good faith judgment of Landlord, violate any
agreement binding upon Landlord, the Building or the Project with regard to the identity of tenants, usage in the Building, or similar matters; 

(v) The assignee or sublessee (or any affiliate of the assignee or sublessee) is then negotiating with Landlord or has
negotiated with Landlord within the previous three (3) months as evidenced by an exchange of proposals, or is a current tenant or subtenant within the Building or Project if Landlord has space in the Building or Project of a similar size and
length of term; 
 (vi) The identity or business reputation of the assignee or sublessee would be reasonably objectionable as
tenants to landlords of Comparable Buildings; 
 (vii) the proposed sublease would result in more than two subleases of
portions of the Premises being in effect at any one time during the Lease Term; or 
 (viii) In the case of a sublease, the
subtenant has not acknowledged that the Lease controls over any inconsistent provision in the sublease. 
 The foregoing criteria shall not
exclude any other reasonable basis for Landlord to refuse its consent to such assignment or sublease. Notwithstanding any contrary provision of this Lease, if Tenant or any proposed assignee or sublessee claims that Landlord has unreasonably
withheld its consent to a proposed assignment or sublease or otherwise has breached its obligations under this Paragraph 11, their sole remedy shall be to seek a declaratory judgment, monetary damages and/or injunctive relief, and, with
respect thereto, Tenant, on behalf of itself and, to the extent permitted by law, such proposed assignee/sublessee, hereby waives all other remedies against Landlord, including, without limitation, the right to terminate this Lease. 

(e) Except as provided in Paragraph 11(1) below, if any Tenant is a corporation, partnership or other entity that is not publicly traded on a
recognized national stock exchange, any transaction or series of related or unrelated transactions (including, without limitation, any dissolution, merger, consolidation or other reorganization, any withdrawal or admission of a partner or change in
a partner’s interest, or any issuance, sale, gift, transfer or redemption of any capital stock of or ownership interest in such entity, whether voluntary, 

  
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involuntary or by operation of law, or any combination of any of the foregoing transactions) resulting in the transfer of control of such Tenant, shall be deemed to be an assignment of this Lease
subject to the provisions of this Section 11. The term “control” as used in this Section 11(e) means the power to directly or indirectly direct or cause the direction of the management or policies of
Tenant. Any transfer of control of a subtenant which is a corporation or other entity shall be deemed an assignment of any sublease. Notwithstanding anything to the contrary in this Section 11(e), if the original Tenant under this Lease is a
corporation, partnership or other entity, a change or series of changes in ownership of stock or other ownership interests which would result in direct or indirect change in ownership of less than fifty percent (50%) of the outstanding stock of or
other ownership interests in such Tenant as of the date of the execution and delivery of this Lease shall not be considered a change of control. 

(f) Notwithstanding any assignment or subletting, Tenant and any guarantor or surety of Tenant’s obligations under this Lease shall at
all times during the Initial Term and any subsequent renewals or extensions remain fully responsible and liable for the payment of the rent and for compliance with all of Tenant’s other obligations under this Lease. In the event that the Rent
due and payable by a sublessee or assignee (or a combination of the rental payable under such sublease or assignment, plus any bonus or other consideration therefor or incident thereto but excluding consideration in connection with the sale of
Tenant) exceeds the Rent payable under this Lease, then Tenant shall be bound and obligated to pay Landlord, as additional rent hereunder, one-half of all such excess Rent and other excess consideration within
thirty (30) days following receipt thereof by Tenant. “Transfer Premium” shall mean all rent, additional rent or other consideration payable (in lieu or in addition to rent) by such transferee in connection with the transfer (as
opposed to the sale of Tenant’s business) in excess of the Rent and Additional Rent payable by Tenant under this Lease during the term of the transfer on a per rentable square foot basis if less than all of the Premises is transferred, after
deducting the reasonable expenses incurred by Tenant for (i) any changes, alterations and improvements to the Premises in connection with the transfer, (ii) any free rent reasonably provided to the transferee, (iii) any brokerage
commissions in connection with the transfer, (iv) any key money, bonus money or other cash consideration paid by Tenant to transferee for furniture, fixtures, equipment and/or similar items; (v) any attorney fees incurred by Tenant in
connection with such transfer (including attorneys’ fees paid to Landlord); (vi) any improvement allowance or other economic concessions (space planning allowance, moving expenses, etc.) paid by Tenant to transferee in connection with such
transfer; and (vii) out-of-pocket marketing costs in connection with the transfer (collectively, “Subleasing Costs”). “Transfer Premium” shall
also include, but not be limited to, key money, bonus money or other cash consideration paid by transferee to Tenant in connection with such transfer (as opposed to the sale of Tenant’s business), and any payment in excess of fair market value
for services rendered by Tenant to transferee or for assets, fixtures, inventory, equipment, or furniture transferred by Tenant to transferee in connection with such transfer. Notwithstanding anything contained herein to the contrary, under no
circumstances shall Landlord be paid any Transfer Premium until Tenant has recovered all Subleasing Costs for such subject space, it being understood that if in any year the gross revenues, less the deductions set forth and included in Subleasing
Costs, are less than any and all costs actually paid in assigning or subletting the affected space (collectively, “Transaction Costs”), the amount of the excess Transaction Costs shall be carried over to the next year and then deducted
from net revenues with the procedure repeated until a Transfer Premium is achieved. 
 (g) If this Lease is assigned or if the Premises is
subleased (whether in whole or in part), or in the event of the mortgage or pledge of Tenant’s leasehold interest, or grant of any concession or license within the Premises, or if the Premises are occupied in whole or in part by anyone other
than Tenant, then upon a default by Tenant hereunder Landlord may collect Rent from the assignee, sublessee, mortgagee, pledgee, concessionee or licensee or other occupant and, except to the extent set forth in the preceding paragraph, apply the
amount collected to the next Rent payable hereunder; and all such Rent collected by Tenant shall be held in deposit for Landlord and immediately forwarded to Landlord. No such transaction or collection of Rent or application thereof by Landlord,
however, shall be deemed a waiver of these provisions or a release of Tenant from the further performance by Tenant of its covenants, duties, or obligations hereunder. 

  
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 (h) If Tenant effects an assignment or sublease or requests the consent of Landlord to any
proposed assignment or sublease, then Tenant shall, within thirty (30) days of demand, pay Landlord a non-refundable administrative fee of One Thousand Dollars ($1,000.00), plus any reasonable
attorneys’ and paralegal fees and costs incurred by Landlord in connection with such assignment or sublease or request for consent not to exceed $2,500.00 in the aggregate. Acceptance of the One Thousand Dollar ($1,000.00) administrative fee
and/or reimbursement of Landlord’s attorneys’ and paralegal fees shall in no event obligate Landlord to consent to any proposed assignment or sublease. 

(i) Notwithstanding any provision of this Lease to the contrary, in the event this Lease is assigned to any person or entity pursuant to the
provisions of the Bankruptcy Code, any and all monies or other consideration payable or otherwise to be delivered in connection with such assignment shall be paid or delivered to Landlord, shall be and remain the exclusive property of Landlord and
shall not constitute the property of Tenant or Tenant’s estate within the meaning of the Bankruptcy Code. All such money and other consideration not paid or delivered to Landlord shall be held in trust for the benefit of Landlord and shall be
promptly paid or delivered to Landlord. 
 (j) The joint and several liability of the Tenant named herein and any immediate and remote successor-in-interest of Tenant (by assignment or otherwise), and the due performance of the obligations of this Lease on Tenant’s part to be performed or observed, shall
not in any way be discharged, released or impaired by any (a) agreement that modifies any of the rights or obligations of the parties under this Lease, (b) stipulation that extends the time within which an obligation under this Lease is to
be performed, (c) waiver of the performance of an obligation required under this Lease, or (d) failure to enforce any of the obligations set forth in this Lease. 

(k) Intentionally deleted. 

(l) Notwithstanding anything to the contrary contained in this Paragraph 11, Landlord shall consent to (and Landlord shall not have any right
to recapture any space pursuant to Paragraph 11(c) or any right to payment of excess Rent pursuant to Paragraph 11(f) with respect to or to collect any transfer fee) an assignment of this Lease or a sublease of all or part of the Premises by Tenant
to any person or entity that is a subsidiary of Tenant or any person or entity which, directly or indirectly, controls Tenant or is controlled by Tenant or is under common control with Tenant, or to any entity into or with which Tenant may be
merged, converted or consolidated or to which all or substantially all of the ownership interests or assets of Tenant are sold as a going concern (collectively a “Successor”), subject to the following conditions (each, a “Permitted
Transfer”); (1) Tenant is not in default hereunder (beyond any applicable notice and cure period); (2) Tenant remains liable for all of its obligations under this Lease (or with respect to an assignment of Tenant’s entire interest in this
Lease to a Successor or if Tenant otherwise ceases to exist as a result of or following the transaction, the Successor must assume, in a document reasonably satisfactory to Landlord, all of Tenant’s obligations under this Lease); (3) the nature
and character of the use of the Premises shall remain the same, and the Tenant shall otherwise comply with the terms of this Paragraph 11 and this Lease; (4) Tenant shall have notified Landlord (and provided Landlord with a copy of the
applicable assignment or sublease document and evidence reasonably satisfactory to Landlord of compliance with this Paragraph 11(1) and with the OFAC requirements as hereafter provided) in writing promptly following the effective date of such
assignment or subletting, and (5) the transaction shall not be a subterfuge to avoid Tenant’s obligations under this Lease. The occurrence of a Permitted Transfer shall not waive Landlord’s rights with respect to any subsequent
assignment, sublease or other transfer. The terms “control”, “controlled by” or “under common controlled with” shall mean the possession, direct or indirect, of the power to direct or cause the
direction of the management and policies of such controlled person or entity; the ownership, directly or indirectly, of at least fifty-one percent (51%) of the voting securities of, or possession of the right
to vote, in the ordinary direction of its affairs, at least fifty-one percent (51%) of the voting interest in, any person or entity shall be presumed to constitute such control. Notwithstanding anything to the
contrary contained herein, provided that there is no change in the executive management of the Tenant, any change of control which occurs through a pledge or sale of Tenant’s equity in connection with financing and/or raising capital shall also
be deemed a Permitted Transfer under this Lease. 

  
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	12.	DEFAULT 

 (a) Events of Default. The occurrence of any one or more of the
following events shall constitute an “event of default” or “default” (herein so called) under this Lease by Tenant: (i) Tenant shall fail to pay Rent or any other rental or sums payable by Tenant hereunder within five
(5) business days after Landlord notifies Tenant of such nonpayment; provided, however, Landlord shall only be obligated to provide such written notice to Tenant two (2) times within any calendar year and in the event Tenant fails to
timely pay Rent or any other sums for a third time during any calendar year, then Tenant shall be in default for such late payment and Landlord shall have no obligation or duty to provide notice of such,
non-payment to Tenant prior to declaring an event of default under this Lease; (ii) the failure by Tenant to observe or perform any of the express or implied covenants or provisions of this Lease to be
observed or performed by Tenant, other than monetary failures as specified in Paragraph 12(a)(i) above, where such failure shall continue for a period of thirty (30) days after written notice thereof from Landlord to Tenant; provided,
however, that if the nature of Tenant’s default is such that more than thirty (30) days are reasonably required for its cure, then Tenant shall not be deemed to be in default if Tenant shall commence such cure within said thirty
(30) day period and thereafter diligently prosecute such cure to completion, which completion shall occur not later than ninety (90) days from the date of such notice from Landlord; (iii) the making by Tenant or any guarantor hereof
of any general assignment for the benefit of creditors, (iv) the filing by or against Tenant or any guarantor hereof of a petition to have Tenant or any guarantor hereof adjudged a bankrupt or a petition for reorganization or arrangement under
any law relating to bankruptcy (unless, in the case of a petition filed against Tenant or any guarantor hereof, the same is dismissed within sixty (60) days), (v) the appointment of a trustee or receiver to take possession of substantially all
of Tenant’s assets located at the Premises or of Tenant’s interest in this Lease or of substantially all of guarantor’s assets, where possession is not restored to Tenant or guarantor within sixty (60) days, (vi) the attachment,
execution or other judicial seizure of substantially all of Tenant’s assets located at the Premises or of substantially all of guarantor’s assets or of Tenant’s interest in this Lease where such seizure is not discharged within sixty
(60) days; (vii) any material representation or warranty made by Tenant or guarantor in this Lease or any other document delivered in connection with the execution and delivery of this Lease or pursuant to this Lease proves to be incorrect in
any material respect; or (viii) Tenant or guarantor shall be liquidated or dissolved or shall begin proceedings towards its liquidation or dissolution. 

Any notice sent by Landlord to Tenant pursuant to this Paragraph 12(a) shall be in lieu of, and not in addition to, any notice required under
California Code of Civil Procedure Section 1161. 
 (b) Landlord’s Remedies; Termination. In the event of any event of
default by Tenant beyond applicable notice and cure periods, in addition to any other remedies available to Landlord under this Lease, at law or in equity, Landlord shall have the immediate option to terminate this Lease and all rights of Tenant
hereunder and Landlord shall have all the rights and remedies of a Landlord provided by Section 1951.2 of the California Civil Code. In the event that Landlord shall elect to so terminate this Lease, then Landlord may recover from Tenant: 

(i) the worth at the time of award of any unpaid rent which had been earned at the time of such termination; plus 

(ii) the worth at the time of the award of the amount by which the unpaid rent which would have been earned after termination
until the time of award exceeds the amount of such rental loss that Tenant proves could have been reasonably avoided; plus 

(iii) the worth at the time of award of the amount by which the unpaid rent for the balance of the term after the time of award
exceeds the amount of such rental loss that Tenant proves could be reasonably avoided; plus 
 (iv) any other amount
necessary to compensate Landlord for all the detriment proximately caused by Tenant’s failure to perform its obligations under this Lease or which, in the ordinary course of things, would be likely to result therefrom including, but not limited
to: unamortized Tenant Improvement costs; attorneys’ fees; brokers’ commissions; the costs of refurbishment, alterations, renovation and repair of the Premises; and removal (including the repair of any damage caused by such removal) and
storage (or disposal) of Tenant’s personal property, equipment, fixtures, Tenant Changes, Tenant Improvements and any other items which Tenant is required under this Lease to remove but does not remove. 

  
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 As used in subparagraph (i) and subparagraph (ii) of Paragraph 12(b) above, the
“worth at the time of award” is computed by allowing interest at the Default Rate (as defined below). As used in subparagraph (iii) of Paragraph 12(b) above, the “worth at the time of award” is computed by
discounting such amount at the discount rate of the Federal Reserve Bank of San Francisco at the time of award plus one percent (1%). 
 (c)
Landlord’s Remedies; Re-Entry Rights. In the event of any event of default by Tenant beyond applicable notice and cure periods, in addition to any other remedies available to Landlord under
this Lease, at law or in equity, Landlord shall also have the right, upon terminating this Lease, to re-enter the Premises and remove all persons and property from the Premises; such property may be removed,
stored and/or disposed of pursuant to Paragraph 5(c) of this Lease or any other procedures permitted by applicable law. No re-entry or taking possession of the Premises by Landlord pursuant to this
Paragraph 12(c), and no acceptance of surrender of the Premises or other action on Landlord’s part, shall be construed as an election to terminate this Lease unless a written notice of such intention be given to Tenant or unless the
termination thereof be decreed by a court of competent jurisdiction. 
 (d) Continuation of Lease. Landlord shall have the remedy
described in California Civil Code Section 1951.4 (lessor may continue lease in effect after lessee’s breach and abandonment and recover rent as it becomes due, if lessee has the right to sublet or assign, subject only to reasonable
limitations). Accordingly, if Landlord does not elect to terminate this Lease on account of any event of default by Tenant, Landlord may, from time to time, without terminating this Lease, enforce all of its rights and remedies under this Lease,
including the right to recover all Rent as it becomes due. 
 (e) Landlord’s Right to Perform. Except as specifically provided
otherwise in this Lease, all covenants and agreements by Tenant under this Lease shall be performed by Tenant at Tenant’s sole cost and expense and without any abatement or offset of Rent. If Tenant shall fail to pay any sum of money (other
than Base Rent) or perform any other act on its part to be paid or performed hereunder and such failure shall continue after Tenant’s receipt of written notice thereof from Landlord and applicable cure periods (except in case of emergencies, in
which such case, such shorter period of time as is reasonable under the circumstances), Landlord may, without waiving or releasing Tenant from any of Tenant’s obligations, make such payment or perform such other act on behalf of Tenant. All
sums so paid by Landlord and all necessary incidental costs incurred by Landlord in performing such other acts shall be payable by Tenant to Landlord within thirty (30) days after demand therefor as Additional Rent. 

(f) Interest. If any monthly installment of Rent or Operating Expenses, or any other amount payable by Tenant hereunder is not received
by Landlord by the date when due, it shall bear interest at the Default Rate from the date due until paid. All interest, and any late charges imposed pursuant to Paragraph 12(g) below, shall be considered Additional Rent due from Tenant to
Landlord under the terms of this Lease. The term “Default Rate” as used in this Lease shall mean the lesser of (A) the rate announced from time to time by Wells Fargo Bank or, if Wells Fargo Bank ceases to exist or ceases to
publish such rate, then the rate announced from time to time by the largest (as measured by deposits) chartered bank operating in the State, as its “prime rate” or “reference rate”, plus three percent (3%), or (B) the
maximum rate of interest permitted by Law. 

  
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 (g) Late Charges. Tenant acknowledges that, in addition to interest costs, the late
payments by Tenant to Landlord of any monthly installment of Base Rent, Additional Rent or other sums due under this Lease will cause Landlord to incur costs not contemplated by this Lease, the exact amount of such costs being extremely difficult
and impractical to fix. Such other costs include, without limitation, processing, administrative and accounting charges and late charges that may be imposed on Landlord by the terms of any mortgage, deed to secure debt, deed of trust or related loan
documents encumbering the Premises, the Building or the Project. Accordingly, if any monthly installment of Base Rent, Additional Rent or any other amount payable by Tenant hereunder is not received by Landlord within five (5) business days
after Landlord provides Tenant with notice that such amount is past due, Tenant shall pay to Landlord an additional sum of five percent (5%) of the overdue amount as a late charge, but in no event more than the maximum late charge allowed by law.
The parties agree that such late charge represents a fair and reasonable estimate of the costs that Landlord will incur by reason of any late payment as hereinabove referred to by Tenant, and the payment of late charges and interest are distinct and
separate in that the payment of interest is to compensate Landlord for the use of Landlord’s money by Tenant, while the payment of late charges is to compensate Landlord for Landlord’s processing, administrative and other costs incurred by
Landlord as a result of Tenant’s delinquent payments. Acceptance of a late charge or interest shall not constitute a waiver of Tenant’s default with respect to the overdue amount or prevent Landlord from exercising any of the other rights
and remedies available to Landlord under this Lease or at law or in equity now or hereafter in effect, 
 (h) Rights and Remedies
Cumulative. All rights, options and remedies of Landlord contained in this Paragraph 12 and elsewhere in this Lease shall be construed and held to be cumulative, and no one of them shall be exclusive of the other, and Landlord shall have
the right to pursue any one or all of such remedies or any other remedy or relief which may be provided by law or in equity, whether or not stated in this Lease. Nothing in this Paragraph 12 shall be deemed to limit or otherwise affect
Tenant’s indemnification of Landlord pursuant to any provision of this Lease. 
 (i) Tenant’s Waiver of Redemption. Tenant
hereby waives and surrenders for itself and all those claiming under it, including creditors of all kinds, (i) any right and privilege which it or any of them may have under any present or future law to redeem any of the Premises or to have a
continuance of this Lease after termination of this Lease or of Tenant’s right of occupancy or possession pursuant to any court order or any provision hereof, and (ii) the benefits of any present or future law which exempts property from
liability for debt or for distress for Rent. 
 (j) Costs Upon Default and Litigation. Subject to Paragraph 19(a), Tenant shall pay
to Landlord and its mortgagees as Additional Rent all the expenses incurred by Landlord or its mortgagees in connection with any default by Tenant hereunder beyond applicable notice and cure periods or the exercise of any remedy by reason of any
default by Tenant hereunder beyond applicable notice and cure periods, including reasonable attorneys’ fees and expenses. If Landlord or its mortgagees shall be made a party to any litigation commenced against Tenant or any litigation
pertaining to this Lease or the Premises, at the option of Landlord and/or its mortgagees, Tenant, at its expense, shall provide Landlord and/or its mortgagees with counsel reasonably approved by Landlord and/or its mortgagees and shall pay all
costs incurred or paid by Landlord and/or its mortgagees in connection with such litigation. 
  

	13.	ACCESS; CONSTRUCTION 

 Landlord reserves from the leasehold estate hereunder, in
addition to all other rights reserved by Landlord under this Lease, the right to use the roof and exterior walls of the Premises and the area beneath, adjacent to and above the Premises so long as such use does not materially and adversely interfere
with Tenant’s use of the Premises for the permitted use. Landlord also reserves the right to install, use, maintain, repair, replace and relocate equipment, machinery, meters, pipes, ducts, plumbing, conduits and wiring through the Premises,
which serve other portions of the Building or the Project in a manner and in locations which do not unreasonably 

  
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interfere with Tenant’s use of the Premises. In addition, Landlord shall have free access to any and all mechanical installations of Landlord or Tenant, including, without limitation,
machine rooms, telephone rooms and electrical closets. Tenant agrees that there shall be no construction of partitions or other obstructions which materially interfere with or which threaten to materially interfere with Landlord’s free access
thereto, or materially interfere with the moving of Landlord’s equipment to or from the enclosures containing said installations. Except in the event of an emergency, Landlord shall at all reasonable times, during normal business hours and
after twenty-four (24) hours written or oral notice, have the right to enter the Premises to inspect the same, to supply janitorial service and any other service to be provided by Landlord to Tenant
hereunder, to exhibit the Premises to prospective purchasers, lenders or tenants (for tenants, only during the last twelve (12) months of the Term), to post notices of non-responsibility, to alter,
improve, restore, rebuild or repair the Premises or any other portion of the Building, or to do any other act permitted or contemplated to be done by Landlord hereunder, all without being deemed guilty of an eviction of Tenant and without liability
for abatement of Rent or otherwise, except as otherwise expressly provided herein; provided, however, any such entry shall be performed in an expeditious manner so as not to unreasonably interfere with Tenant’s use of or access to the Premises.
Landlord shall use commercially reasonable efforts to schedule entries into the Premises under this Paragraph 13 with Tenant (except entries for provision of janitorial services and for emergency services) so that Tenant, at Tenant’s option,
may provide a representative to accompany Landlord. Even in emergency situations, Landlord shall use commercially reasonable efforts to minimize any disruption to Tenant’s business operations. For such purposes, Landlord may also erect
scaffolding and other necessary structures where reasonably required by the character of the work to be performed. Landlord shall conduct all such inspections and/or improvements, alterations and repairs so as to minimize, to the extent reasonably
practical and without material additional expense to Landlord, any interruption of or interference with the business of Tenant. Except as otherwise expressly provided herein, Tenant hereby waives any claim for damages for any injury or inconvenience
to or interference with Tenant’s business, any loss of occupancy or quiet enjoyment of the Premises, and any other loss occasioned thereby. For each of such purposes. Landlord shall at all times have and retain a key with which to unlock all of
the doors in, upon and about the Premises (excluding Tenant’s vaults and safes, access to which shall be provided by Tenant upon Landlord’s reasonable request). Landlord shall have the right to use any and all means which Landlord may deem
proper in an emergency in order to obtain entry to the Premises or any portion thereof, and Landlord shall have the right, at any time during the Lease Term, to provide whatever access control measures it deems reasonably necessary to the Project,
without any interruption or abatement in the payment of Rent by Tenant, except as otherwise expressly provided herein. Any entry into the Premises obtained by Landlord by any of such means shall not under any circumstances be construed to be a
forcible or unlawful entry into, or a detainer of, the Premises, or any eviction of Tenant from the Premises or any portion thereof. No provision of this Lease shall be construed as obligating Landlord to perform any repairs, Alterations or
decorations to the Premises or the Project except as otherwise expressly agreed to be performed by Landlord pursuant to the provisions of this Lease. Notwithstanding anything to the contrary set forth in this Paragraph 13, Tenant may designate
certain areas of the Premises as “Secured Areas” should Tenant require such areas for the purpose of securing certain valuable property or confidential information. In connection with the foregoing, Landlord shall not enter such Secured
Areas except in the event of an emergency. Landlord need not clean any area designated by ‘Tenant as a Secured Area and shall only maintain or repair such Secured Areas to the extent (i) such repair or maintenance is required in order to
maintain and repair the Building structure and/or the Building systems; (ii) as required by Law, or (iii) in response to specific requests by Tenant and in accordance with a schedule reasonably designated by Tenant, subject to
Landlord’s reasonable approval. 
  

	14.	BANKRUPTCY 

 (a) If at any time on or before the Commencement Date there shall be
filed by or against Tenant in any court, tribunal, administrative agency or any other forum having jurisdiction, pursuant to any applicable law, either of the United States or of any state, a petition in bankruptcy or insolvency or for
reorganization or for the appointment of a receiver, trustee or conservator of all or a portion of Tenant’s property, or if Tenant makes an assignment for the benefit of creditors, this Lease shall ipso facto be canceled and terminated
and in such event 

  
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neither Tenant nor any person claiming through or under Tenant or by virtue of any applicable law or by an order of any court, tribunal, administrative agency or any other forum having
jurisdiction, shall be entitled to possession of the Premises and Landlord, in addition to the other rights and remedies given by Paragraph 12 hereof or by virtue of any other provision contained in this Lease or by virtue of any applicable
law, may retain as damages any Rent, Security Deposit or moneys received by it from Tenant or others on behalf of Tenant. 
 (b) If, after
the Commencement Date, or if at any time during the term of this Lease, there shall be filed against Tenant in any court, tribunal, administrative agency or any other forum having jurisdiction, pursuant to any applicable law, either of the United
States or of any state, a petition in bankruptcy or insolvency or for reorganization or for the appointment of a receiver, trustee or conservator of all or a portion of Tenant’s property, and the same is not dismissed after sixty
(60) calendar days, or if Tenant makes an assignment for the benefit of creditors, this Lease, at the option of Landlord exercised within a reasonable time after notice of the happening of any one or more of such events, may be canceled and
terminated and in such event neither Tenant nor any person claiming through or under Tenant or by virtue of any statute or of an order of any court shall be entitled to possession or to remain in possession of the Premises, but shall forthwith quit
and surrender the Premises, and Landlord, in addition to the other rights and remedies granted by Paragraph 12 hereof or by virtue of any other provision contained in this Lease or by virtue of any applicable law, may retain as damages any
Rent, Security Deposit or moneys received by it from Tenant or others on behalf of Tenant. 
  

	15.	SUBSTITUTION OF PREMISES 

 Subject to the conditions specified in this
Paragraph 15, Landlord reserves the right without Tenant’s consent after giving not less than 90 days prior notice, may move Tenant to other space in the Building comparable in size and utility to the Premises, provided that the size of
the new space is no less than ninety-five percent (95%) of the original Premises. In addition, such other space must: (i) contain similar finishes, quality and layout as the Premises, and the same or
greater number of work stations, offices, breakrooms, ping pong room and reception areas as are contained in the Premises as of the date Tenant receives Landlord’s notice of relocation; and (ii) be located on the ground floor. In such
event, all terms hereof shall apply to the new space, except that Base Rent and Tenant’s Proportionate Share shall not increase as a result of such relocation (if the substituted premises are larger and shall decrease proportionately if the new
space is smaller than the Premises. Landlord, at its expense, shall provide Tenant with tenant improvements in the new space at least equal in quality to those in the Premises. Landlord shall reimburse Tenant for Tenant’s reasonable out-of-pocket costs incurred in connection with such relocation, including without limitation, moving, re-cabling, installing
Tenant’s furniture, fixtures and equipment signage and stationery-replacement costs. The parties shall execute a written agreement prepared by Landlord memorializing the relocation. Unless otherwise
agreed to in writing by Tenant, Landlord shall effect the relocation move into the new space during a weekend or any Holiday or after 5:00 p.m. on a Friday (the “Approved Relocation Times”) so that Tenant’s business is not interrupted
during the relocation. Notwithstanding the foregoing, if Landlord fails to substantially complete the relocation during the Approved Relocation Times and, as a result thereof, Tenant cannot open in the Relocation Space on the business day
immediately following the relocation during the Approved Relocation Times, Tenant shall be entitled to receive a per diem abatement of Base Rent for each business day the relocation prohibits the Tenant from operating its business during such
business day(s) as a result of the acts or omissions Tenant, its agents, employees or contractors. 
  

	16.	SUBORDINATION; ATTORNMENT; ESTOPPEL CERTIFICATES 

 (a) Tenant agrees that this
Lease and the rights of Tenant hereunder shall be subject and subordinate to any and all deeds to secure debt, deeds of trust, security interests, mortgages, master leases, ground leases or other security documents and any and all modifications,
renewals, extensions, consolidations and replacements thereof (collectively, “Security Documents”) which now or hereafter constitute a lien upon or affect the Project, the Building or the Premises. Such subordination shall be
effective without the necessity of the execution by Tenant of any additional document for the purpose of evidencing or effecting such subordination. In addition, 

  
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Landlord shall have the right to subordinate or cause to be subordinated any such Security Documents to this Lease and in such case, in the event of the termination or transfer of Landlord’s
estate or interest in the Project by reason of any termination or foreclosure of any such Security Documents, Tenant shall, notwithstanding such subordination, attorn to and become the Tenant of the successor-in-interest to Landlord at the option of such successor-in-interest. Furthermore, Tenant shall within fifteen
(15) days of demand therefor execute any commercially reasonable instruments or other documents which may be required by Landlord or the holder of any Security Document and specifically shall execute, acknowledge and deliver within fifteen
(15) days of demand therefor a commercially reasonable subordination of lease or subordination of deed of trust or mortgage; the failure to do so by Tenant within such time period shall be a material default hereunder; provided, however, the
new landlord or the holder of any Security Document shall agree that Tenant’s quiet enjoyment of the Premises shall not be disturbed as long as Tenant is not in default under this Lease. 

(b) If any proceeding is brought for default under any ground or master lease to which this Lease is subject or in the event of foreclosure or
the exercise of the power of sale under any mortgage, deed of trust or other Security Document made by Landlord covering the Premises, at the election of such ground lessor, master lessor or purchaser at foreclosure, Tenant shall attorn to and
recognize the same as Landlord under this Lease, provided such successor expressly agrees in writing to be bound to all future obligations by the terms of this Lease, and if so requested, Tenant shall enter into a new lease with that successor on
the same terms and conditions as are contained in this Lease (for the unexpired term of this Lease then remaining). Tenant hereby waives its rights under any current or future law which gives or purports to give Tenant any right to terminate or
otherwise adversely affect this Lease and the obligations of Tenant hereunder in the event of any such foreclosure proceeding or sale. 

(c) Intentionally deleted. 

(d) Tenant shall, upon not less than ten (10) business days’ prior notice by the Landlord, execute, acknowledge and deliver to
Landlord a commercially reasonable statement in writing which certification has been requested by Landlord or any current or prospective purchaser, holder of any Security Document, ground lessor or master lessor, including, but without limitation,
that (i) this Lease is unmodified and in full force and effect (or if there have been modifications, that the same is in full force and effect as modified and stating the modifications), (ii) the dates to which the Base Rent, Additional Rent
and other charges hereunder have been paid, if any, and (iii) whether or not to the actual knowledge of Tenant, Landlord is in default in the performance of any covenant, agreement or condition contained in this Lease and, if so, specifying
each such default of which Tenant may have actual knowledge. The form of the statement attached hereto as Exhibit D is hereby approved by Tenant for use pursuant to this subparagraph (d); however, at
Landlord’s option, Landlord shall have the right to use other forms for such purpose. Tenant’s failure to execute and deliver such statement within such time shall, at the option of Landlord, constitute a material default under this Lease
and, in any event, shall be conclusive upon Tenant that this Lease is in full force and effect without modification except as may be represented by Landlord in any such certificate prepared by Landlord and delivered to Tenant for execution. Any
statement delivered pursuant to this Paragraph 16 may be relied upon by any prospective purchaser of the fee of the Building or the Project or any mortgagee, ground lessor or other like encumbrances thereof or any assignee of any such
encumbrance upon the Building or the Project. 
  

	17.	SALE BY LANDLORD; TENANT’S REMEDIES; NONRECOURSE LIABILITY 

(a) In the event of a sale or conveyance by Landlord of the Building or the Project, Landlord shall be released from any and all liability
under this Lease thereafter arising so long as such obligations were assumed by such new purchaser. If the Security Deposit has been deposited by Tenant to Landlord prior to such sale or conveyance, Landlord shall transfer the Security Deposit to
the purchaser, and upon delivery to Tenant of notice thereof, Landlord shall be discharged from any further liability in reference thereto. 

  
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 (b) Landlord shall not be in default of any obligation of Landlord hereunder unless Landlord
fails to perform any of its obligations under this Lease within thirty (30) days after receipt of written notice of such failure from Tenant; provided, however, that if the nature of Landlord’s obligation is such that more than thirty
(30) days are required for its performance, Landlord shall not be in default if Landlord commences to cure such default within the thirty (30) day period and thereafter diligently prosecutes the same to completion. All obligations of
Landlord under this Lease will be binding upon Landlord only during the period of its ownership of the Project and not thereafter, subject to Paragraph 17(a) above. All obligations of Landlord hereunder shall be construed as covenants, not
conditions; and, except as may be otherwise expressly provided in this Lease, Tenant may not terminate this Lease for breach of Landlord’s obligations hereunder. 

(c) Notwithstanding anything contained in this Lease to the contrary, the obligations of Landlord under this Lease (including any actual or
alleged breach or default by Landlord) do not constitute personal obligations of the individual partners, directors, officers, trustees, members or shareholders of Landlord or Landlord’s members or partners, and Tenant shall not seek recourse
against the individual partners, directors, officers, trustees, members or shareholders of Landlord or against Landlord’s members or partners or against any other persons or entities having any interest in Landlord, or against any of their
personal assets for satisfaction of any liability with respect to this Lease. Any liability of Landlord for a default by Landlord under this Lease, or a breach by Landlord of any of its obligations under the Lease, shall be limited solely to its
interest in the Project, and in no event shall any personal liability be asserted against Landlord in connection with this Lease nor shall any recourse be had to any other property or assets of Landlord, its partners, directors, officers, trustees,
members, shareholders or any other persons or entities having any interest in Landlord. Tenant’s sole and exclusive remedy for a default or breach of this Lease by Landlord shall be either (i) an action for damages, or (ii) an action
for injunctive relief; Tenant hereby waiving and agreeing that Tenant shall have no offset rights or right to terminate this Lease on account of any breach or default by Landlord under this Lease. Under no circumstances whatsoever shall Landlord
ever be liable for punitive, consequential or special damages under this Lease and Tenant waives any rights it may have to such damages under this Lease in the event of a breach or default by Landlord under this Lease. Notwithstanding anything in
this Lease to the contrary, nothing in this Lease shall impose any obligations upon Landlord or Tenant to be responsible or liable for, and each hereby releases the other from all liability for, consequential damages, other than those consequential
damages incurred by Landlord in connection with a holdover of the Premises by Tenant after the expiration or earlier termination of this Lease or incurred by Landlord in connection with any repair, physical construction or improvement work performed
by or on behalf of Tenant in the Project. 
 (d) As a condition to the effectiveness of any notice of default given by Tenant to Landlord,
Tenant shall also concurrently give such notice under the provisions of Paragraph 17(b) to each beneficiary under a Security Document encumbering the Project of whom Tenant has received written notice (such notice to specify the address of
the beneficiary). In the event Landlord shall fail to cure any breach or default within the time period specified in Paragraph 17(b). then prior to any termination of this Lease by Tenant, each such beneficiary shall have an additional thirty
(30) days within which to cure such default, or if such default cannot reasonably be cured within such period, then each such beneficiary shall have such additional time as shall be necessary to cure such default, provided that within such
thirty (30) day period, such beneficiary has commenced and is diligently pursuing the remedies available to it which are necessary to cure such default (including, without limitation, as appropriate, commencement of foreclosure proceedings).

  

	18.	PARKING; COMMON AREAS 

 (a) Tenant shall have the right to the nonexclusive use,
except as otherwise provided in Item 13 of the Basic Lease Provisions, of the number of parking spaces located in the parking areas of the Project specified in Item 13 of the Basic Lease Provisions
for the parking of operational motor vehicles used by Tenant, its officers and employees only. Landlord reserves the right, at any time upon written notice to Tenant, to designate the location of Tenant’s parking spaces as determined by
Landlord in its reasonable and non-discriminatory 

  
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discretion. The use of such spaces shall be subject to the reasonable and non-discriminatory rules and regulations adopted by Landlord from time to time
for the use of the parking areas. Landlord further reserves the right to make such changes to the parking system as Landlord may deem necessary or reasonable from time to time; i.e., Landlord may provide for one or a combination of parking systems,
including, without limitation, self-parking, single or double stall parking spaces, and valet assisted parking. Except as otherwise expressly agreed to in this Lease, Tenant agrees that Tenant, its officers
and employees shall not be entitled to park in any reserved or specially assigned areas designated by Landlord from time to time in the Project’s parking areas. Landlord may require execution of a commercially reasonable agreement with respect
to the use of such parking areas by Tenant and/or its officers and employees as a condition of any such use by Tenant, its officers and employees. A default by Tenant, its officers or employees in the payment of such charges, the compliance with
such rules and regulations, or the performance of such agreement(s) shall constitute a default by Tenant hereunder subject to applicable notice and cure periods. Tenant shall not permit or allow any vehicles that belong to or are controlled by
Tenant or Tenant’s officers, employees, suppliers, shippers, customers or invitees to be loaded, unloaded or parked in areas other than those reasonably designated by Landlord for such activities. If Tenant repeatedly permits or allows any of
the prohibited activities described in this Paragraph, then Landlord shall have the right, without notice, in addition to such other rights and remedies that it may have, to remove or tow away the vehicle involved and charge the cost to Tenant,
which cost shall be immediately payable within thirty (30) days of demand by Landlord. 
 (b) Subject to subparagraph
(c) below and the remaining provisions of this Lease, Tenant shall have the nonexclusive right, in common with others, to the use of such entrances, lobbies, fire vestibules, restrooms (excluding restrooms on any full floors leased by a
tenant), mechanical areas, ground floor corridors, elevators and elevator foyers, electrical and janitorial closets, telephone and equipment rooms, loading and unloading areas, the Project’s plaza areas, if any, ramps, drives, stairs, and
similar access ways and service ways and other common areas and facilities in and adjacent to the Building and the Project as are reasonably designated from time to time by Landlord for the general nonexclusive use of Landlord, Tenant and the other
tenants of the Project and their respective employees, agents, representatives, licensees and invitees (“Common Areas”). The use of such Common Areas shall be subject to the reasonable and
non-discriminatory rules and regulations contained herein and the provisions of any covenants, conditions and restrictions affecting the Building or the Project; provided, however, that such rules, regulations
and restrictions shall not materially and adversely interfere with Tenant’s permitted use of the Premises, Building or the Project parking facilities and shall not be unreasonably or discriminatorily modified or enforced. Tenant shall keep all
of the Common Areas free and clear of any obstructions created or permitted by Tenant or resulting from Tenant’s operations, and shall use the Common Areas only for normal activities, parking and ingress and egress by Tenant and its employees,
agents, representatives, licensees and invitees to and from the Premises, the Building or the Project. If, in the reasonable opinion of Landlord, unauthorized persons are using the Common Areas by reason of the presence of Tenant in the Premises,
Tenant, upon demand of Landlord, shall correct such situation by appropriate action or proceedings against all such unauthorized persons. Nothing herein shall affect the rights of Landlord at any time to remove any such unauthorized persons from
said areas or to prevent the use of any of said areas by unauthorized persons. Landlord reserves the right to make such changes, alterations, additions, deletions, improvements, repairs or replacements in or to the Building, the Project (including
the Premises) and the Common Areas as Landlord may reasonably deem necessary or desirable, including, without limitation, constructing new buildings and making changes in the location, size, shape and number of driveways, entrances, parking spaces,
parking areas, loading areas, landscaped areas and walkways; provided such closures, alterations or changes do not change the nature of the Project to something other than a first-class office building project
or materially and adversely affect Tenant’s use of the Premises, Building or Project or the Project parking facilities for the permitted use; provided, however, that (i) there shall be no unreasonable permanent obstruction of access to or
use of the Premises resulting therefrom, and (ii) Landlord shall use commercially reasonable efforts to minimize any interruption with Tenant’s use of the Premises. In the event that the Project is not completed on the date of execution of
this Lease, Landlord shall have the sole judgment and discretion to determine the architecture, design, appearance, construction, workmanship, materials and equipment with respect to construction of the Project. Notwithstanding any provision

  
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of this Lease to the contrary, the Common Areas shall not in any event be deemed to be a portion of or included within the Premises leased to Tenant and the Premises shall not be deemed to be a
portion of the Common Areas. This Lease is granted subject to the terms hereof, the rights and interests of third parties under existing liens, ground leases, easements and encumbrances affecting such property, all zoning regulations, rules,
ordinances, building restrictions and other laws and regulations now in effect or hereafter adopted by any governmental authority having jurisdiction over the Project or any part thereof. Notwithstanding anything above to the contrary, Landlord
shall maintain and operate the Project in a manner materially consistent with that of other Comparable Buildings, shall maintain and operate the Project in a manner materially consistent with that of other Comparable Buildings. Tenant shall have
access to the Premises, the Building, Project and the parking areas servicing the same twenty-four (24) hours per day, seven (7) days per week, three hundred
sixty-five (365) days per year; provided that such access shall: (i) be in accordance with all reasonable security measures as may be imposed by Landlord from time to time and as are generally
applicable to tenants of the Building and their invitees; and (ii) be subject to restrictions on access recommended or imposed as a result of an emergency. 

(c) Notwithstanding any provision of this Lease to the contrary, Landlord specifically reserves the right to redefine the term
“Project” for purposes of allocating and calculating Operating Expenses so as to include or exclude areas as Landlord shall from time to time determine or specify (and any such determination or specification shall be without
prejudice to Landlord’s right to revise thereafter such determination or specification). In addition, Landlord shall have the right to contract or otherwise arrange for amenities, services or utilities (the cost of which is included within
Operating Expenses) to be on a common or shared basis to both the Project (i.e., the area with respect to which Operating Expenses are determined) and adjacent areas not included within the Project, so long as the basis on which the cost of such
amenities, services or utilities is allocated to the Project is determined on an arms-length basis or some other basis reasonably and equitably determined by Landlord. In the case where the definition of the
Project is revised for purposes of the allocation or determination of Operating Expenses, Tenant’s Proportionate Share shall be appropriately revised to equal the percentage share of all Rentable Area contained within the Project (as then
defined) represented by the Premises. The Rentable Area of the Project is subject to adjustment by Landlord from time to time to reflect any remeasurement thereof by Landlord’s architect, at Landlord’s request, and/or as a result of any
additions or deletions to any of the buildings in the Project as designated by Landlord. Landlord shall have the sole right to determine which portions of the Project and other areas, if any, shall be served by common management, operation,
maintenance and repair. Landlord shall also have the right, in its sole discretion, to equitably allocate and prorate any portion or portions of the Operating Expenses on a
building-by-building basis, on an aggregate basis of all buildings in the Project, or any other reasonable manner, and if allocated on a
building-by-building basis, then Tenant’s Proportionate Share shall, as to the portion of the Operating Expenses so allocated, be based on the ratio of the Rentable
Area of the Premises to the Rentable Area of the Building. Landlord shall have the exclusive rights to the airspace above and around, and the subsurface below, the Premises and other portions of the Building and Project. 

 

	19.	MISCELLANEOUS 

 (a) Attorneys’ Fees. In the event of any legal action
or proceeding brought by either party against the other arising out of this Lease, the prevailing party shall be entitled to recover reasonable attorneys’ fees and costs (including, without limitation, court costs and expert witness fees)
incurred in such action. Such amounts shall be included in any judgment rendered in any such action or proceeding. 
 (b) Waiver. No
waiver by Landlord or Tenant of any provision of this Lease or of any breach by Tenant or Landlord hereunder shall be deemed to be a waiver of any other provision hereof, or of any subsequent breach by Tenant or Landlord. Landlord’s or
Tenant’s consent to or approval of any act by Tenant or Landlord requiring Landlord’s or Tenant’s consent or approval under this Lease shall not be deemed to render unnecessary the obtaining of Landlord’s or Tenant’s consent
to or approval of any subsequent act of Tenant or Landlord. No act or thing done by Landlord or Landlord’s agents during the term of this Lease shall be deemed an acceptance of a surrender of the Premises, unless in writing signed by Landlord.
The delivery of the keys to any employee or 

  
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agent of Landlord shall not operate as a termination of the Lease or a surrender of the Premises. The acceptance of any Rent by Landlord following a breach of this Lease by Tenant shall not
constitute a waiver by Landlord of such breach or any other breach unless such waiver is expressly stated in a writing signed by Landlord. 

(c) Notices. Any notice, demand, request, consent, approval, disapproval or certificate (“Notice”) required or desired
to be given under this Lease shall be in writing and given by certified mail, return receipt requested, by personal delivery or by a nationally recognized overnight delivery service (such as Federal Express or UPS) providing a receipt for delivery.
Notices may not be given by facsimile. The date of giving any Notice shall be deemed to be the date upon which delivery is actually made by one of the methods described in this Section 19(c) (or attempted if said delivery is refused or
rejected). If a Notice is received on a Saturday, Sunday or legal holiday, it shall be deemed received on the next business day. All notices, demands, requests, consents, approvals, disapprovals, or certificates shall be addressed at the address
specified in Item 14 of the Basic Lease Provisions or to such other addresses as may be specified by written notice from Landlord to Tenant and if to Tenant, at the Premises. Either party may change its address by giving reasonable
advance written Notice of its new address in accordance with the methods described in this Paragraph; provided, however, no notice of either party’s change of address shall be effective until fifteen (15) days after the addressee’s
actual receipt thereof. For the purpose of this Lease, Landlord’s counsel may provide Notices to Tenant on behalf of Landlord and such notices shall be binding on Tenant as if such notices have been provided directly by Landlord. 

(d) Access Control. Landlord shall be the sole determinant of the type and amount of any access control or courtesy guard services to
be provided to the Project, if any; provided, however, Landlord agrees that the Building shall be monitored after-hours by a card-key or fob access system and that
Landlord shall provide such access card-keys or fobs to Tenant at Landlord’s expense. IN ALL EVENTS, LANDLORD SHALL NOT BE LIABLE TO TENANT, AND TENANT HEREBY WAIVES ANY CLAIM AGAINST LANDLORD, FOR
(I) ANY UNAUTHORIZED OR CRIMINAL ENTRY OF THIRD PARTIES INTO THE PREMISES, THE BUILDING OR THE PROJECT, (II) ANY DAMAGE TO PERSONS, OR (III) ANY LOSS OF PROPERTY IN AND ABOUT THE PREMISES, THE BUILDING OR THE PROJECT, BY OR FROM ANY
UNAUTHORIZED OR CRIMINAL ACTS OF THIRD PARTIES, REGARDLESS OF ANY ACTION, INACTION, FAILURE, BREAKDOWN, MALFUNCTION AND/OR INSUFFICIENCY OF THE ACCESS CONTROL OR COURTESY GUARD SERVICES PROVIDED BY LANDLORD, IF ANY. Tenant shall provide such
supplemental security services and shall install within the Premises such supplemental security equipment, systems and procedures as may reasonably be required for the protection of its employees and invitees, provided that Tenant shall coordinate
such services and equipment with any security provided by Landlord. The determination of the extent to which such supplemental security equipment, systems and procedures are reasonably required shall be made in the sole judgment, and shall be the
sole responsibility, of Tenant. Except as provided herein, Tenant acknowledges that it has neither received nor relied upon any representation or warranty made by or on behalf of Landlord with respect to the safety or security of the Premises or the
Project or any part thereof or the extent or effectiveness of any security measures or procedures now or hereafter provided by Landlord, and further acknowledges that Tenant has made its own independent determinations with respect to all such
matters. 
 (e) Storage. Any storage space at any time leased to Tenant hereunder shall be used exclusively for storage.
Notwithstanding any other provision of this Lease to the contrary, (i) Landlord shall have no obligation to provide heating, cleaning, water or air conditioning therefor, and (ii) Landlord shall be obligated to provide to such storage
space only such electricity as will, in Landlord’s judgment, be adequate to light said space as storage space. 
 (f) Holding
Over. If Tenant retains possession of the Premises after the termination or expiration of the Lease Term, then Tenant shall, at Landlord’s election become a tenant at sufferance (and not a tenant at will), such possession shall be subject
to immediate termination by Landlord at any time, and all of the other terms and provisions of this Lease (excluding any expansion or renewal option or other similar right or option) shall be 

  
 40 

 
applicable during such holdover period, except that Tenant shall pay Landlord from time to time, within thirty (30) days of demand, as Base Rent for the holdover period, an amount equal to
150% of the Base Rent in effect on the termination date, computed on a monthly basis for each month or part thereof during such holding over. All other payments (including payment of Additional Rent) shall continue under the terms of this Lease. In
addition, Tenant shall be liable for all damages incurred by Landlord as a result of such holding over. No holding over by Tenant, whether with or without consent of Landlord, shall operate to extend this Lease except as otherwise expressly
provided, and this Paragraph shall not be construed as consent for Tenant to retain possession of the Premises. 
 (g) Condition of
Premises. EXCEPT AS OTHERWISE EXPRESSLY PROVIDED IN THIS LEASE, LANDLORD HEREBY DISCLAIMS ANY EXPRESS OR IMPLIED REPRESENTATION OR WARRANTY THAT THE PREMISES ARE SUITABLE FOR TENANT’S INTENDED PURPOSE OR USE, WHICH DISCLAIMER IS HEREBY
ACKNOWLEDGED BY TENANT. THE TAKING OF POSSESSION BY TENANT SHALL BE CONCLUSIVE EVIDENCE THAT TENANT WAIVES ALL CLAIMS BASED ON ANY IMPLIED WARRANTY OF SUITABILITY OR HABITABILITY. 

(h) Quiet Possession. Upon Tenant’s paying the Rent reserved hereunder and observing and performing all of the covenants,
conditions and provisions on Tenant’s part to be observed and performed hereunder within applicable notice and cure periods, Tenant shall have quiet possession of the Premises for the term hereof without hindrance or ejection by any person
lawfully claiming under Landlord, subject to the provisions of this Lease and to the provisions of any (i) covenants, conditions and restrictions, (ii) master lease, or (iii) Security Documents to which this Lease is subordinate or
may be subordinated. 
 (i) Matters of Record. Except as otherwise provided herein, this Lease and Tenant’s rights hereunder are
subject and subordinate to all matters affecting Landlord’s title to the Project recorded in the Real Property Records of the County in which the Project is located, prior to and subsequent to the date hereof, including, without limitation, all
covenants, conditions and restrictions; provided, however, no covenants, conditions or restrictions or other documents affecting the Project or amendments thereto shall materially and adversely (i) affect Tenant’s use of the Premises,
Building or Project or the Project parking facilities for the permitted use, (ii) affect Tenant’s rights under this Lease, or (iii) increase Tenant’s obligations under this Lease. Tenant agrees for itself and all persons in
possession or holding under it that it will comply with and not violate any such covenants, conditions and restrictions or other matters of record of which it has received written notice. Landlord reserves the right, from time to time, to grant such
easements, rights and dedications as Landlord deems necessary or desirable, and to cause the recordation of parcel maps and covenants, conditions and restrictions affecting the Premises, the Building or the Project, as long as such easements,
rights, dedications, maps, and covenants, conditions and restrictions do not materially interfere with the use of the Premises by Tenant. At Landlord’s request, Tenant shall join in the execution of any of the aforementioned documents. 

(j) Successors and Assigns. Except as otherwise provided in this Lease, all of the covenants, conditions and provisions of this Lease
shall be binding upon and shall inure to the benefit of the parties hereto and their respective heirs, personal representatives, successors and assigns. Tenant shall attorn to each purchaser, successor or assignee of Landlord. 

(k) Brokers. Tenant warrants that it has had no dealings with any real estate broker or agent in connection with the negotiation of
this Lease, excepting only the brokers named in Item 12 of the Basic Lease Provisions and that it knows of no other real estate broker or agent who is or might be entitled to a commission in connection with this Lease. Tenant hereby
agrees to indemnify, defend and hold Landlord harmless for, from and against all claims for any brokerage commissions, finders’ fees or similar payments by any persons claiming through Tenant other than those listed in Item 12 of
the Basic Lease Provisions and all costs, expenses and liabilities incurred in connection with such claims, including reasonable attorneys’ fees and costs. Landlord agrees to pay the brokers listed in Item 12 a brokerage
commission pursuant to a separate written agreement. Landlord 

  
 41 

 
warrants that it has had no dealings with any real estate broker or agent in connection with the negotiation of this Lease, excepting only the Landlord’s Broker named in Item
12 of the Basic Lease Provisions and that it knows of no other real estate broker or agent who is or might be entitled to a commission in connection with this Lease other than the Tenant’s Broker, Landlord hereby agrees to indemnify,
defend and hold Tenant harmless for, from and against all claims for any brokerage commissions, finders’ fees or similar payments by any persons claiming through Landlord other than those listed in Item 12 of the Basic Lease
Provisions and all costs, expenses and liabilities incurred in connection with such claims, including reasonable attorneys’ fees and costs. 

(l) Project or Building Name and Signage. Landlord shall have the right at any time to install, affix and maintain any and all signs on
the exterior and on the interior of the Project or Building as Landlord may, in Landlord’s sole discretion, desire. Tenant shall not use the name of the Project or Building or use pictures or illustrations of the Project or Building in
advertising or other publicity or for any purpose other than as the address of the business to be conducted by Tenant in the Premises, without the prior written consent of Landlord. Additionally, Landlord shall have the exclusive right at all times
during the Lease Term to change, modify, add to or otherwise alter the name, number, or designation of the Building and/or the Project, and Landlord shall not be liable for claims or damages of any kind which may be attributed thereto or result
therefrom. 
 (m) Examination of Lease. Submission of this instrument for examination or signature by Tenant does not constitute a
reservation of or option for lease, and it is not effective as a lease or otherwise until execution by and delivery to both Landlord and Tenant. 

(n) Time. Time is of the essence of this Lease and each and all of its provisions. 

(o) Defined Terms and Marginal Headings. The words ‘‘Landlord” and “Tenant” as used herein shall include the
plural as well as the singular and for purposes of Paragraphs 5, 7, 13 and 18, the term Landlord shall include Landlord, its employees, contractors and agents. The marginal headings and titles to the articles of this Lease are not a part of
this Lease and shall have no effect upon the construction or interpretation of any part hereof. 
 (p) Conflict of Laws; Prior
Agreements; Separability. This Lease shall be governed by and construed pursuant to the laws of the State of California. This Lease contains all of the agreements of the parties hereto with respect to any matter covered or mentioned in this
Lease. No prior agreement, understanding or representation pertaining to any such matter shall be effective for any purpose. No provision of this Lease may be amended or added to except by an agreement in writing signed by the parties hereto or
their respective successors in interest. The illegality’, invalidity or unenforceability of any provision of this Lease shall in no way impair or invalidate any other provision of this Lease, and such remaining provisions shall remain in full
force and effect. 
 (q) Authority. If Tenant is a corporation or limited liability company, hereby covenants and warrants that
Tenant is a duly authorized and existing corporation or limited liability company, that Tenant has and is qualified to do business in the State, that the corporation or limited liability company has full right and authority to enter into this Lease,
and that each person signing on behalf of the corporation is authorized to do so. If Tenant is a partnership or trust, Tenant hereby covenants and warrants that such person is duly authorized to execute and deliver this Lease on behalf of Tenant in
accordance with the terms of such entity’s partnership or trust agreement. Tenant shall provide Landlord within thirty (30) days of demand with such evidence of such authority as Landlord shall reasonably request, including, without
limitation, resolutions, certificates and opinions of counsel. This Lease shall not be construed to create a partnership, joint venture or similar relationship or arrangement between Landlord and Tenant hereunder. 

(r) Joint and Several Liability. If two or more individuals, corporations, partnerships or other business associations (or any
combination of two or more thereof) shall sign this Lease as Tenant, the liability of each such individual, corporation, partnership or other business association to pay Rent and perform all other 

  
 42 

 
obligations hereunder shall be deemed to be joint and several, and all notices, payments and agreements given or made by, with or to any one of such individuals, corporations, partnerships or
other business associations shall be deemed to have been given or made by, with or to all of them. In like manner, if Tenant shall be a partnership or other business association, the members of which are, by virtue of statute or federal law, subject
to personal liability, then the liability of each such member shall be joint and several. 
 (s) Rental Allocation. For purposes of
Section 467 of the Internal Revenue Code of 1986, as amended from time to time, Landlord and Tenant hereby agree to allocate all Rent to the period in which payment is due, or if later, the period in which Rent is paid. 

(t) Rules and Regulations. Tenant agrees to comply with all rules and regulations of the Building and the Project imposed by Landlord
as set forth on Exhibit C attached hereto, and any reasonable and non-discriminatory changes thereto from time to time upon reasonable notice to Tenant; provided, however,
that such rules, regulations and restrictions shall not materially and adversely interfere with Tenant’s permitted use of the Premises, Building or Project or Project parking facilities and shall not be unreasonably or discriminatorily modified
or enforced. Tenant shall use commercially reasonable efforts to cause its agents, employees, representatives, invitees, licensees and subtenants to comply with such rules and regulations. To the extent any rules and regulations are contrary to the
terms of this Lease, the terms of this Lease shall prevail. Landlord shall not be liable to Tenant for the failure of any other tenant or any of its assignees, subtenants, or their respective agents, employees, representatives, invitees or licensees
to conform to such rules and regulations but shall use reasonable efforts to enforce if such failure adversely affects Tenant’s use of or access to the Building, parking or Premises. 

(u) Joint Product. This Agreement is the result of arms-length negotiations between Landlord
and Tenant and their respective attorneys. Accordingly, neither party shall be deemed to be the author of this Lease and this Lease shall not be construed against either party. 

(v) Financial Statements. Upon Landlord’s written request, but not more than once in any calendar year, and after executing a
commercially reasonable non-disclosure agreement, Tenant shall promptly furnish Landlord, from time to time, with the most current audited financial statements prepared in accordance with generally accepted
accounting principles, certified by Tenant and an independent auditor to be true and correct, reflecting Tenant’s then current financial condition as are prepared in the ordinary course of business. 

(w) Force Majeure. Any prevention, delay or stoppage due to strikes, lockouts, labor disputes, acts of God, acts of war, terrorism,
terrorist activities, inability to obtain services, labor, or materials or reasonable substitutes therefore, governmental actions, civil commotions, fire, flood, earthquake or other casualty, and other causes beyond the reasonable control of the
party obligated to perform, except with respect to the obligations imposed with regard to Rent and other charges to be paid by Tenant pursuant to this Lease and except as to Tenant’s obligations under Article 6 and Article 8 of
this Lease and Section 19(f) of this Lease (collectively, a “Force Majeure”), notwithstanding anything to the contrary contained in this Lease, shall excuse the performance of such party for a period equal to any such
prevention, delay or stoppage and, therefore, if this Lease specifies a time period for performance of an obligation of either party, that time period shall be extended by the period of any delay in such party’s performance caused by a Force
Majeure. 
 (x) Counterparts. This Lease may be executed in several counterparts, each of which shall be deemed an original, and all
of which shall constitute but one and the same instrument. 
 (y) Waiver of Right to Jury Trial. LANDLORD AND
TENANT WAIVE THEIR RESPECTIVE RIGHTS TO TRIAL BY JURY OF ANY CONTRACT OR TORT CLAIM, COUNTERCLAIM, CROSS-COMPLAINT, OR CAUSE OF ACTION IN ANY ACTION, PROCEEDING, OR HEARING BROUGHT BY EITHER PARTY AGAINST
THE OTHER ON ANY MATTER ARISING OUT OF OR 

  
 43 

 
IN ANY WAY CONNECTED WITH THIS LEASE, THE RELATIONSHIP OF LANDLORD AND TENANT, OR
TENANT’S USE OR OCCUPANCY OF THE LEASED PREMISES, INCLUDING WITHOUT LIMITATION ANY CLAIM OF INJURY OR DAMAGE OR
THE ENFORCEMENT OF ANY REMEDY UNDER ANY CURRENT OR FUTURE LAW, STATUTE, REGULATION, CODE, OR ORDINANCE. Landlord and Tenant agree that
this paragraph constitutes a written consent to waiver of trial by jury within the meaning of California Code of Civil Procedure Section 631(a)(2), and Landlord and Tenant do hereby authorize and empower Landlord or Tenant to file this paragraph
and/or this Lease, as required, with the clerk or judge of any court of competent jurisdiction as a written consent to waiver of jury trial. 

(z) Office and Communications Services. Landlord has advised Tenant that certain office and communications services may be offered to
tenants of the Building by a concessionaire under contract to Landlord (“Provider”). Tenant shall be permitted to contract with Provider for the provision of any or all of such services on such terms and conditions as Tenant and
Provider may agree. Tenant acknowledges and agrees that: (i) Landlord has made no warranty or representation to Tenant with respect to the availability of any such services, or the quality, reliability or suitability thereof; (ii) the
Provider is not acting as the agent or representative of Landlord in the provision of such services, and Landlord shall have no liability or responsibility for any failure or inadequacy of such services, or any equipment or facilities used in the
furnishing thereof, or any act or omission of Provider, or its agents, employees, representatives, officers or contractors; (iii) Landlord shall have no responsibility or liability for the installation, alteration, repair, maintenance,
furnishing, operation, adjustment or removal of any such services, equipment or facilities; and (iv) any contract or other agreement between Tenant and Provider shall be independent of this Lease, the obligations of Tenant hereunder, and the
rights of Landlord hereunder, and, without limiting the foregoing, no default or failure of Provider with respect to any such services, equipment or facilities, or under any contract or agreement relating thereto, shall have any effect on this Lease
or give to Tenant any offset or defense to the full and timely performance of its obligations hereunder, or entitle Tenant to any abatement of rent or additional rent or any other payment required to be made by Tenant hereunder, or constitute any
accrual or constructive eviction of Tenant, or otherwise give rise to any other claim of any nature against Landlord. 
 (aa) OFAC
Compliance. 
 (i) Certification. Tenant certifies, represents, warrants and covenants that: 

(A) It is not acting and will not act, directly or indirectly, for or on behalf of any person, group, entity, or nation named by any
Executive Order or the United States Treasury Department as a terrorist, “Specially Designated National and Blocked Person”, or other banned or blocked person, entity, nation or transaction pursuant to any law, order, rule, or regulation
that is enforced or administered by the Office of Foreign Assets Control; and 
 (B) It is not engaged in this transaction, directly or
indirectly on behalf of, or instigating or facilitating this transaction, directly or indirectly on behalf of, any such person, group, entity or nation. 

(ii) Indemnity. Tenant hereby agrees to defend (with counsel reasonably acceptable to Landlord), indemnify and hold
harmless Landlord and the Landlord Indemnitees from and against any and all Claims arising from or related to any such breach of the foregoing certifications, representations, warranties and covenants. 

(bb) No Easement For Light, Air And View. This Lease conveys to Tenant no rights for any light, air or view. No diminution of light,
air or view, or any impairment of the visibility of the Premises from inside or outside the Building, by any structure or other object that may hereafter be erected (whether or not by Landlord) shall entitle Tenant to any reduction of Rent under
this Lease, constitute an actual or constructive eviction of 

  
 44 

 
Tenant, result in any liability of Landlord to Tenant, or in any other way affect this Lease or Tenant’s obligations hereunder; provided, however, notwithstanding anything to the contrary,
Landlord agrees that Landlord shall not install any signage or other covering over any of Tenant’s windows including without limitation “wrap signage”. 

(cc) Nondisclosure of Lease Terms. Tenant agrees that the terms of this Lease are confidential and constitute proprietary information
of Landlord, and that disclosure of the terms hereof could adversely affect the ability of Landlord to negotiate with other tenants. Tenant hereby agrees that Tenant and its partners, officers, directors, employees, agents, real estate brokers and
sales persons and attorneys shall not disclose the terms of this Lease to any other person without Landlord’s prior written consent, except to any accountants of Tenant in connection with the preparation of Tenant’s financial statements or
tax returns, to an assignee of this Lease or subtenant of the Premises, or to an entity or person to whom disclosure is require by applicable law or in connection with any action brought to enforce this Lease. 

(dd) Intentionally deleted. 

(ee) ERISA. Tenant is not an “employee benefit plan” as defined in Section 3(3) of the Employee Retirement Income
Security Act of 1974 (“ERISA”), which is subject to Title I of ERISA, or a “plan” as defined in Section 4975(e)(1) of the Internal Revenue Code of 1986, which is subject to Section 4975 of the Internal Revenue Code of
1986; and (b) the assets of Tenant do not constitute “plan assets” of one or more such plans for purposes of Title I of ERISA or Section 4975 of the Internal Revenue Code of 1986; and (c) Tenant is not a “governmental
plan” within the meaning of Section 3(32) of ERISA, and assets of Tenant do not constitute plan assets of one or more such plans; or (d) transactions by or with Tenant are not in violation of state statutes applicable to Tenant
regulating investments of and fiduciary obligations with respect to governmental plans. 
 (ff) Separate Account. Notwithstanding
anything contained in this Lease or in any other document executed in connection with the transaction contemplated hereby to the contrary and without limitation of Paragraph 17(c) hereof, any liability of Landlord shall be satisfied solely
from the assets and properties of the Teachers Insurance and Annuity Association of America’s Real Estate Account established as a separate investment account of TIAA under New York law on February 22, 1995, and under the regulation of the
State of New York Insurance Department (the “Separate Account”) (including all assets and properties allocated to or held for the account of the Separate Account), and in no event shall any recourse be had to any assets or
properties held by TIAA in its general investment account or in any other of its existing or future separate accounts other than the Separate Account. The provisions of this Paragraph 19(ff) will survive the expiration or earlier termination
of this Lease. 
 (gg) Tenant’s Signage. Tenant shall be entitled to (i) one (1)
Building-standard directory listing on each of the two (2) main lobby directories in the Building (“Directory Board Listing”), the location of such directories shall be in Landlord’s
sole and absolute discretion, and (ii) one (1) interior Building-standard suite signage located outside of the Premises, but near the entrance to the Premises, the location of which shall be designated by
Landlord (“Interior Suite Signage”). Landlord shall install such signage at Landlord’s cost, and Tenant shall be responsible for the cost of all replacements or repairs thereto. The style, type, color, size, and design of the
Directory Board Listing and Interior Suite Signage shall be designated by Landlord and shall comply with all sign criteria for the Building and all zoning, covenants, conditions and restrictions affecting the Project. 

(hh) CASp Disclosure. As of the Effective Date, the Project has not undergone inspection by a Certified Access Specialist (CASp). 

(ii) Tenant’s Security System. Landlord agrees that Landlord shall not unreasonably withhold, condition or delay its
consent to Tenant installing, maintaining and replacing from time to time, at Tenant’s sole cost and expense, a security system for its Premises (“Tenant’s Security System”); provided, however, and

  
 45 

 
notwithstanding the foregoing, Landlord shall have the right to access the Premises in the event of an emergency and Tenant shall provide Landlord with the necessary access codes, keys or similar
means necessary for Landlord to be able to access the Premises. Notwithstanding the foregoing, Tenant’s Security System shall be subject to, and in compliance, with all applicable governmental Laws, applicable conditions, covenants and
restrictions affecting the Building and shall be compatible with any Landlord security or access system installed at the Building. Tenant shall be solely responsible for the cost and expense of obtaining and maintaining any necessary permits for
Tenant’s Security System and any licenses related thereto, and for the cost and expense of maintenance and utilities for Tenant’s Security System, if any. The means and method of installation of Tenant’s Security System in the
Building shall be subject to Landlord’s prior written approval, which approval shall not be unreasonably withheld, conditioned or delayed. Tenant shall be responsible for the repair of any damage to any portion of the Premises and/or Building
caused by Tenant’s installation, use or removal of Tenant’s Security System. All rights and remedies of Landlord under the Lease (including, without limitation, Landlord’s self-help remedies)
shall apply in the event Tenant fails to install and/or maintain Tenant’s Security System as herein required. Upon the expiration or earlier termination of this Lease, Tenant shall pay all costs associated with the removal of Tenant’s
Security System and the restoration of the Premises (or any area in the Building outside of the Premises) where Tenant’s Security System is located to as near its original condition as may then be reasonably required by Landlord. The terms and
provisions of this Paragraph 19(ii) shall survive the expiration or earlier termination of this Lease. 
 (jj) Existing
Furniture. Tenant, in Tenant’s sole discretion and at no additional cost to Tenant shall have the right and be entitled to use the office furniture, desks, tables and chairs existing in the Premises as of the Date of this Lease, as further
described on Exhibit B-3 attached hereto (such furniture, cubicles, desks and chairs being collectively referred to herein as the “Existing
Furniture”). No later than thirty (30) days after the Date of this Lease, Tenant shall notify Landlord in writing whether Tenant has elected to use all or some of the Existing Furniture or require Landlord, at Landlord’s sole cost
and expense, to remove all or some of the Existing Furniture prior to the Commencement Date. Notwithstanding the foregoing, Landlord hereby agrees to remove the pieces of furniture depicted in Schedule 1 to Exhibit
B-3. In the event Tenant elects to use any or all of the Existing Furniture throughout the Lease Term, such Existing Furniture which Tenant elects to use shall be
delivered with the Premises in its AS-IS, WHERE-IS and WITH ALL FAULTS condition, and Tenant hereby disclaims any and all warranties with respect to such Existing
Furniture, whether express or implied (including, without limitation, any warranty of merchantability or fitness for a particular purpose). Furthermore, Tenant hereby understands and agrees that throughout the Lease Term, Tenant shall, at
Tenant’s sole cost and expense, maintain, repair and keep such Existing Furniture in good working order, normal wear and tear excepted and Landlord shall have no obligation whatsoever to maintain, repair or replace any of such Existing
Furniture, or to insure any of such Existing Furniture, and any loss or damage to such Existing Furniture shall be at Tenant’s sole risk and Tenant hereby releases Landlord from any obligation with respect thereto. Such Existing Furniture is
and shall remain the property of Landlord and Tenant shall not remove or otherwise discard, modify and/or add to such Existing Furniture without Landlord’s prior written consent, which shall not be unreasonably withheld, delayed or conditioned.
Notwithstanding the foregoing, Tenant shall have the right to move or reconfigure such Existing Furniture within the Premises throughout the Lease Term. Upon the expiration or earlier termination of this Lease, Tenant shall surrender such Existing
Furniture in the Premises in a safe, clean and neat condition, normal wear and tear excepted. 
 (kk) Roof Access. Landlord agrees
that Tenant may install, maintain and replace from time to time one (1) satellite dish or similar antenna device, in a location reasonably designated by Landlord, the height and width of such devices to be reasonably acceptable to Landlord
(hereinafter, the “Satellite Dish”) on the roof of the Building free of charge, subject to the following: (a) applicable governmental laws; (b) the right of Landlord to supervise any roof penetrations;
(c) Landlord’s approval of the plans and specifications for the Satellite Dish and all connecting cables from the roof of the Building to the Premises; (d) compliance with the conditions of any roof bond maintained by Landlord on the
Premises; (e) the Satellite Dish not being visible at street level, and (f) the Satellite Dish not interfering with any then existing satellite dish or other antenna on the roof of the Building.

  
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Tenant shall be responsible for the repair of any damage to any portion of the Building caused by Tenant’s installation, use or removal of the Satellite Dish. The Satellite Dish shall remain
the exclusive property of Tenant, and Tenant shall have the right to remove same at any time during the term of the Lease. Tenant shall protect, defend, indemnify and hold harmless Landlord from and against any and all claims, damages, liabilities,
costs or expenses of every kind and nature (including without limitation reasonable attorney’s fees) imposed upon or incurred by or asserted against Landlord arising out of Tenant’s installation, maintenance, use or removal of the
Satellite Dish, which indemnity shall survive the expiration or earlier termination of the Lease. 
 [SIGNATURE PAGE TO FOLLOW]

  
 47 

 SIGNATURE PAGE TO OFFICE LEASE 

BY AND BETWEEN TEACHERS INSURANCE AND ANNUITY ASSOCIATION OF AMERICA, AS 

LANDLORD, AND SIENNA BIOPHARMACEUTICALS, INC., AS TENANT 

IN WITNESS WHEREOF, the parties have executed this Lease to be effective as of the Date of this Lease. 

 

									
	“LANDLORD”:	 		 	“TENANT”:
			
	TEACHERS INSURANCE AND ANNUITY ASSOCIATION OF AMERICA, for the benefit of its Real Estate Account	 		 	 SIENNA BIOPHARMACEUTICALS, INC.,

a Delaware corporation

					
	By:	 	 /s/ Erik Sobek
	 		 	By:	 	 /s/ Frederick Beddingfield

	Name:	 	 Erik Sobek
	 		 	Name:	 	 Frederick Beddingfield

	Title:	 	 Senior Director
	 		 	Title:	 	 President and CEO

					
	Date: 	 	5/10, 2016	 		 		 	

  
 48 

 EXHIBIT A-1 

FLOOR PLAN OF THE PREMISES 
  

 

  
 A-1-1 

 EXHIBIT A-1 

LEGAL DESCRIPTION OF THE PROJECT 
  

 

  
 A-1-2 

 EXHIBIT B 

WORK LETTER 
 (a)
Landlord agrees to furnish or perform, at Landlord’s sole cost and expense, in a good workmanlike manner utilizing Building-standard materials and finishes: 

(i) Demise the Premises as set forth in Exhibit
B-l and Exhibit B-2 hereto; 

(ii) construction of those improvements specified in Exhibit B-l and Exhibit B-2 (collectively, the “Tenant Improvements”), attached hereto; and 

(iii) (A) install new carpet and tile flooring on the first floor lobby and first floor Common Area corridors, (B) repaint
the first floor lobby and first floor Common Area corridors, (C) install new furniture in the first floor lobby, and (D) cosmetically refurbish existing restrooms on the first floor with finishes and fixtures similar to those finishes in
the second floor restrooms ((A) - (D), collectively, the “Refurbishment Work”). 

(b) If Tenant shall desire any changes in the Tenant Improvements (including any upgrades, or above
Building-standard materials or finishes), Tenant shall so advise Landlord in writing and Landlord shall price such changes and provide notice to Tenant of any delays caused by such changes. Any and all costs
of reviewing any requested changes, and any and all costs of making any changes to the Tenant Improvements which Tenant may request shall be at Tenant’s sole cost and expense and shall be paid to Landlord upon demand and before execution of the
change order. 
 (c) Landlord shall proceed with and complete the construction of the Tenant Improvements. Landlord shall use commercially
reasonable efforts to complete the Refurbishment Work within ninety (90) days following the Commencement Date, however Landlord shall be the sole determinant regarding the scope, extent, style, finish, and the type of materials used in, the
Refurbishment Work except to the extent set forth in Subsection (a)(ii) above. Landlord shall complete the Refurbishment Work in accordance with laws and in a good and workmanlike manner. As soon as such improvements have been Substantially
Completed, Landlord shall notify Tenant in writing of the date that the Tenant Improvements were Substantially Completed. The Tenant Improvements shall be deemed substantially completed (“Substantially Completed”) when, in the
opinion of the Landlord’s architect (whether an employee or agent of Landlord or a third party architect) (“Architect”), the Premises are substantially completed and a Certificate of Occupancy or its legal equivalent allowing
legal occupancy has been issued except for punch list items which do not prevent in any material way the use of the Premises for the purposes for which they were intended. Without limiting the foregoing, Tenant shall be solely responsible for delays
caused by Tenant’s request for any changes in the plans, Tenant’s request for long lead items, Tenant’s request for installing upgraded or
non-Building-standard items, or Tenant’s interference with the construction of the Tenant Improvements (each of the foregoing, a “Tenant Delay”),
and such Tenant Delays shall not cause a deferral of the Commencement Date beyond what it otherwise would have been; provided, however, no delay by Tenant shall be deemed to have occurred until after Landlord has given Tenant written notice of such
delay and Tenant has failed to cure such delay within two (2) business days. Notwithstanding the foregoing, Landlord and Tenant shall work in good faith with each other and use commercially reasonable efforts not to use long lead items in
connection with the Tenant Improvements. After the Commencement Date Tenant shall, within ten (10) business days of demand, execute and deliver to Landlord an accurate letter of acceptance of delivery of the Premises. 

The failure of Tenant to take possession of or to occupy the Premises shall not serve to relieve Tenant of obligations arising on the Commencement Date or
delay the payment of Rent by Tenant. Except for incomplete punch list items which shall be completed as soon as possible thereafter. Tenant upon the Commencement Date shall have and hold the Premises as the same shall then be without any liability
or obligation on the part of Landlord for making any further alterations or improvements of any kind in or about the Premises except as required by this Exhibit B. 

  
 B-1 

 EXHIBIT B-l 

TENANT IMPROVEMENTS 
 Scope of
Landlord’s work is based on the attached Demolition Plan and Space Plan prepared by View Design Studio (undated), attached as Exhibit B-2 below.
Landlord’s scope is strictly limited to the following: 
  

	 	A.	LANDLORD’S BUILDING STANDARD SCOPE OF WORK: 

  

	 	1.	Demolition: Remove certain existing partitions in the space in order to achieve the overall space configuration as shown. Demolition includes elimination of the storage room next to the existing breakroom, front
wall and door at the breakroom, and a door cut-in for a new exit door within the expanded breakroom. Remove all existing floor coverings. 

 

	 	2.	Partitions – Scar patch and finish wall ends where storage room was removed to enlarge the existing breakroom and add a single exit door utilizing building standard components. 

 

	 	3.	Door Assemblies – Provide and install one new building standard exit door assembly, with a keyed lockset only, located in the enlarged breakroom. Re-finish
existing doors as necessary. 

  

	 	4.	Acoustical Ceilings – Existing ceiling system will generally remain in place. Patch grid where necessary to place in good condition and replace ceiling tiles that display highly visible damage.

  

	 	5.	Millwork – Cabinetry in break room. 

  

	 	6.	Glass & Glazing – Double entry doors will not receive a sidelight as it is not consistent with the project. 

 

	 	7.	Floor finishes – Building standard carpet (up to two patterns), baseboard throughout. Provide and install new VCT and cove base in the break room. Tenant shall select colors from Landlord’s
building standard materials. 

  

	 	8.	Wall finishes – All walls to receive one coat of primer and one coat of paint in a building standard color as selected by Tenant (up to two colors). 

 

	 	9.	Lighting Fixtures – See Item# 16 below. Landlord will ensure all lamps are in good working order. 

  

	 	10.	Power Requirements – All existing power in the premises shall remain, including in the existing server room. All existing power / circuits feeding the existing workstations shall remain as is. The
reception area will receive one wall fed undedicated quad outlet and one voice and data outlet adjacent to the tenant supplied reception desk. Notwithstanding the foregoing, Landlord shall add in the Premises (except in the ping pong/conference
room) additional electrical outlets as set forth in Item #6 in the notes set forth in the space plan in Exhibit B-2 attached hereto 

 

	 	11.	Air conditioning – The existing zones and overall supply air and return air grills shall remain as is. Conduct air balancing of the space. 

 

	 	12.	Fire Sprinklers – All sprinkler heads in the premises shall remain as is. 

  

	 	13.	Fire Alarm System – None, unless required by law to complete Landlord’s work contained herein. 

  

	 	14.	Plumbing – New sink with hot/cold water, garbage disposal and dish washer. 

  

	 	15.	Window treatments at perimeter windows – Existing coverings to be placed in good working order and replace as needed. 

 

	 	16.	Lights – Landlord shall be financially responsible for additive costs and schedule impacts related to the addition of light fixtures within the Premises, excluding the ping pong/conference room (which is at
Tenant’s sole cost), that could trigger Title 24 Energy compliance. This would include engineering, plan check approvals and permits, and all work related to installing tenant’s light fixtures in the Premises, but excluding the ping
pong/conference room. 

  
 B-1-1 

	 	B.	TENANT’S SCOPE OF WORK: 

Tenant’s responsibility in connection with the tenant improvement work shall include but is not necessarily limited to the following: 

 

	 	1.	Furniture, Fixtures, and Equipment (“FF&E”) including any new work stations, furnishings, and reception desk. 

  

	 	2.	Removal of existing voice and data cabling and installation of new cabling 

  

	 	3.	Telephone systems and networking systems 

  

	 	4.	Security card access systems (see below under add alternates) 

  

	 	5.	Appliances & any interior signage/graphics. 

  

	 	C.	ADD ALTERNATES 

 The following are add alternate items to be selected by Tenant and
costs for the below items shall be at Tenant’s expense: 
  

	 	1.	Tenant shall be financially responsible for additive costs and schedule impacts related to their desire to add a ping pong/conference room within the Premises that could trigger Title 24 Energy compliance. This would
include engineering, plan check approvals and permits, and all work related such ping pong/conference room. 

  

	 	2.	Provide power, electrified hardware, make necessary door/frame modifications, and patch existing walls/and paint affected walls to accommodate Tenant’s card access system. Excludes the card access system.

  

	 	3.	Tenant shall be financially responsible for additive costs and schedule impacts related to their desire to add power within the ping pong/conference room. Costs would include all necessary engineering, plan check
approvals and permits, opening and patching of existing walls and ceilings. Scope can vary as it depends on Tenant’s electrical needs thus requires tenant’s determination on the scope. 

 

	 	4.	Replace all existing ceiling tiles in the premises with new ceiling tiles. 

  

	 	5.	Construct a new “Ping Pong/conference room” with full front glass per the space plan. Provide a new building standard door at the Ping Pong/conference room. The Ping Pong/conference room will receive two new
wall fed undedicated outlets and two voice & data outlets. The Ping Pong/conference room will receive a new supply ducting and grill from an existing zone, along with a return air grill. Slight modifications to the fire sprinkler heads will
occur at the enlarged breakroom and at the new Ping Pong/conference room. Provide an aluminum frame and full front glass around the proposed Ping Pong/conference room. 

The add alternate items must be approved within three (3) business days of receipt of Landlord’s cost to Tenant to minimize potential schedule
delays relating to the add alternate items. 

  
 B-1-2 

 EXHIBIT B-2 

DESCRIPTION OF CERTAIN TENANT IMPROVEMENTS 

SEE ATTACHED 

  
 B-2-1 

 

 

  
 B-2-2 

 

 
  

  
 B-2-3 

 EXHIBIT B-3 

EXISTING FURNITURE INVENTORY 
  

					
	 Suite 140 Furniture Inventory
	  		  	
	 Date: 4/20/2016
	  		  	
			
	 	  	 RH/LH
	  	 Qty

	 Office Sets:
	  		  	
	 Wood desk w/return
	  	 RH
	  	6
	 Desk Chair
	  		  	
	 2 wooden side chairs
	  		  	
			
	 Wood desk w/return
	  	 LH
	  	7
	 Desk Chair
	  		  	
	 2 wooden side chairs
	  		  	
			
	 Wood desk w/return
	  	 RH
	  	2
	 Desk Chair
	  		  	
	 No side chairs
	  		  	
			
	 	  	 Drawers
	  	 Qty

	File cabinets:	  		  	
	 Metal file cabinets - Lateral
	  	4	  	7
	 Metal file cabinets - Lateral
	  	2	  	9
	 Wood file cabinets - Lateral
	  	2	  	26
	 Metal file cabinets
	  	2	  	1
			
	 	  	 Shelves
	  	 Qty

	Book Shelves:	  		  	
	 Wood Open
	  	4	  	2
	 Wood Open
	  	3	  	1
	 Wood Open (double)
	  	3	  	1
	 Wood Open
	  	5	  	2
			
	 	  	 Chairs
	  	 Qty

	Confernce table:	  		  	
	 Wood - Large oval
	  	14	  	1
	 Wood - Small Oval
	  	6	  	1
	 Wood - Small Round
	  	3	  	1
			
	 Work Stations:
	  		  	
	 Tall w/desk chair
	  		  	12
	 Short w/desk chair
	  		  	12
			
	 	  	 	  	 Qty

	Misc:	  		  	
	 Stand alone cunter top with 2 3-drawer cabinets - laminate
	  		  	1
	 Tall wood chair
	  		  	1
	 Small Side table
	  		  	2
	 Desk Return w/desk chair
	  		  	1
	 Extra Desk Chairs
	  		  	19
	 Work Table
	  		  	3
	 Round Kicthen Table
	  		  	1
	 Kitchen Chairs
	  		  	4
	 Small metal cabinet
	  		  	1
	 Extra wood side chairs (reception)
	  		  	2
	 Open cabinet- lamintae
	  		  	1
	 Wood Recption work station
	  		  	1
	 Metal cabinet w/Doors - Tall Double
	  		  	2

  
 B-3-1 

 SCHEDULE ONE TO EXHIBIT B-3 

SEE ATTACHED 

  
 Schedule One to Exhibit
B-3-1 

 

 

  
 Schedule One to Exhibit
B-3-2 

 

 

  
 Schedule One to Exhibit
B-3-3 

 

 

  
 Schedule One to Exhibit
B-3-4 

 

 

  
 Schedule One to Exhibit
B-3-5 

 

 

  
 Schedule One to Exhibit
B-3-6 

 

 

  
 Schedule One to Exhibit
B-3-7 

 

 

  
 Schedule One to Exhibit
B-3-8 

 

 

  
 Schedule One to Exhibit
B-3-9 

 

 

  
 Schedule One to Exhibit
B-3-10 

 

 

  
 Schedule One to Exhibit
B-3-11 

 EXHIBIT C 

BUILDING RULES AND REGULATIONS 

1. The sidewalks, entrances, passages, courts, elevators, vestibules, stairways and corridors of halls shall not be obstructed or used for any
purpose other than ingress and egress. The halls, passages, entrances, elevators, stairways, balconies and roof are not for the use of the general public, and the Landlord shall in all cases retain the right to control and prevent access thereto of
all persons whose presence, in the judgment of the Landlord, shall be prejudicial to the safety, character, reputation and interests of the Building and its tenants, provided that nothing herein contained shall be construed to prevent such access to
persons with whom the Tenant normally deals only for the purpose of conducting its business in the Premises (such as clients, customers, office suppliers and equipment vendors, and the like) unless such persons are engaged in illegal activities. No
tenant and no employees of any tenant shall go upon the roof of the Building without the written consent of Landlord. 
 2. No awnings or
other projections shall be attached to the outside walls of the Building. No curtains, blinds, shades or screens shall be attached to or hung in, or used in connection with, any exterior window or door of the Premises other than Landlord standard
window coverings. All electrical ceiling fixtures hung in offices or spaces along the perimeter of the Building must be of a quality, type, design and bulb color approved by Landlord. Neither the interior nor the exterior of any windows shall be
coated or otherwise sunscreened without the written consent of Landlord. 
 3. No sign, advertisement, notice or handbill shall be
exhibited, distributed, painted or affixed by any tenant on, about or from any part of the exterior of the Premises, the Building or the Project without the prior written consent of the Landlord. If the Landlord shall have given such consent at the
time, whether before or after the execution of this Lease, such consent shall in no way operate as a waiver or release of any of the provisions hereof or of this Lease, and shall be deemed to relate only to the particular sign, advertisement or
notice so consented to by the Landlord and shall not be construed as dispensing with the necessity of obtaining the specific written consent of the Landlord with respect to each and every such sign, advertisement or notice other than the particular
sign, advertisement or notice, as the case may be, so consented to by the Landlord. In the event of the violation of the foregoing by any tenant, Landlord may remove or stop same without any liability, and may charge the expense incurred in such
removal or stopping to such tenant. Interior signs on exterior doors and the directory tablet shall be inscribed, painted or affixed for each tenant by the Landlord at the expense of such tenant, and shall be of a size, color and style acceptable to
the Landlord. Except as set forth in the Lease, the directory tablet will be provided exclusively for the display of the name and location of tenants only and Landlord reserves the right to exclude any other names therefrom. Nothing may be placed on
the exterior of corridor walls or corridor doors other than Landlord’s standard lettering. 
 4. The sashes, sash doors, skylights,
windows, and doors that reflect or admit light and air into Common Area halls, passageways or other public places in the Building shall not be covered or obstructed by any tenant, nor shall any bottles, parcels or other articles be placed on the
window sills. Tenant shall see that the exterior windows, transoms and doors of the Premises are closed and securely locked before leaving the Building and must observe strict care not to leave windows open when it rains. Tenant shall exercise
extraordinary care and caution that all water faucets or water apparatus are entirely shut off before Tenant or Tenant’s employees leave the Building, and that all electricity, gas or air shall likewise be carefully shut off, so as to prevent
undue waste or damage. Tenant shall not tamper with or change the setting of any thermostats or temperature control valves. 
 5. The toilet
rooms, water and wash closets and other plumbing fixtures shall not be used for any purpose other than those for which they were constructed, and no sweepings, rubbish, rags or other substances shall be thrown therein. All damages resulting from any
misuse of the fixtures shall be borne by the tenant who, or whose subtenants, assignees or any of their servants, employees, agents, visitors or licensees shall have caused the same. 

  
 C-1 

 6. No tenant shall mark, paint, drill into, or in any way deface any part of the Building
(outside of the Premises) or the Project. No boring, cutting or stringing of wires or laying of linoleum or other similar floor coverings shall be permitted, except with the prior written consent of the Landlord and as the Landlord may direct. 

7. No bicycles, vehicles, birds or animals of any kind shall be brought into or kept in or about the Premises, and no cooking shall be done or
permitted by any tenant on the Premises, except that the preparation of coffee, tea, hot chocolate and similar items (including those suitable for microwave heating) for tenants and their employees shall be permitted, provided that the power
required therefor shall not exceed that amount which can be provided by a 30 amp circuit. No tenant shall cause or permit any unusual or objectionable odors to be produced or permeate the Premises. Smoking or carrying lighted cigars, cigarettes or
pipes in the Building is prohibited. 
 8. The Premises shall not be used for manufacturing or for the storage of merchandise except as such
storage may be incidental to the permitted use of the Premises. No tenant shall occupy or permit any portion of the Premises to be occupied as an office for a public stenographer or typist, or for the manufacture or sale of liquor, narcotics, or
tobacco (except by a cigarette vending machine for use by Tenant’s employees) in any form, or as a medical office, or as a barber or manicure shop, or as an employment bureau, without the express written consent of Landlord. No tenant shall
engage or pay any employees on the Premises except those actually working for such tenant on the Premises nor advertise for laborers giving an address at the Premises. The Premises shall not be used for lodging or sleeping or for any illegal
purposes. 
 9. No tenant shall make, or permit to be made any unseemly or disturbing noises to emanate from the Premises or disturb or
interfere with occupants of this or neighboring buildings or premises or those having business with them, whether by the use of any musical instrument, radio, phonograph, unusual noise, or in any other way. No tenant shall throw anything out of
doors, windows or skylights or down the passageways. 
 10. No tenant, subtenant or assignee nor any of their servants, employees, agents,
visitors or licensees shall at any time bring or keep upon the Premises any inflammable, combustible or explosive fluid, chemical or substance, other than items incidental to general office use. 

11. No additional locks or bolts of any kind shall be placed upon any of the doors or windows by any tenant, nor shall any changes be made in
existing locks or the mechanisms thereof. Each tenant must, upon the termination of his tenancy, restore to Landlord all keys of stores, offices, and toilet rooms, either furnished to, or otherwise procured by, such tenant and in the event of the
loss of keys so furnished, such tenant shall pay to Landlord the cost of replacing the same or of changing the lock or locks opened by such lost key if Landlord shall deem it necessary to make such changes. 

12. All removals, or the carrying in or out of any safes, freight, furniture, or bulky matter of any description must take place during the
hours which Landlord shall reasonably determine from time to time, without the express written consent of Landlord. The moving of safes or other fixtures or bulky matter of any kind must be done upon previous notice to the Project Management Office
and under its supervision, and the persons employed by any tenant for such work must be reasonably acceptable to the Landlord. Landlord reserves the right to inspect all safes, freight or other bulky articles to be brought into the Building and to
exclude from the Building all safes, freight or other bulky articles which violate any of these Rules and Regulations or the Lease of which these Rules and Regulations are a part. Landlord reserves the right to prescribe the weight and position of
all safes, which must be placed upon supports approved by Landlord to distribute the weight. 
 13. No tenant shall purchase janitorial
maintenance or other similar services from any person or persons not reasonably approved by Landlord. 

  
 C-2 

 14. Intentionally deleted. 

15. Landlord shall have the right to prohibit any advertising by any tenant which, in Landlord’s opinion, tends to impair the reputation
of the Building or the Project or its desirability as an office location, and upon written notice from Landlord, any tenant shall refrain from or discontinue such advertising. 

16. Landlord reserves the right to exclude from the Building between the hours of 6:00 P.M. and 7:00 A.M. and at all hours on Saturday, Sunday
and legal holidays all persons who do not present a pass or card key to the Building approved by the Landlord. Each tenant shall be responsible for all persons who enter the Building with or at the invitation of such tenant and shall be liable to
Landlord for all acts of such persons. Landlord shall in no case be liable for damages for any error with regard to the admission to or exclusion from the Building of any person. In case of an invasion, mob riot, public excitement or other
circumstances rendering such action advisable in Landlord’s opinion, Landlord reserves the right, without abatement of Rent, to require all persons to vacate the Building and to prevent access to the Building during the continuance of the same
for the safety of the tenants, the protection of the Building, and the property in the Building. 
 17. Any persons employed by any tenant
to do janitorial work shall, while in the Building and outside of the Premises, be subject to and under the control and direction of the Project Management Office (but not as an agent or servant of said Office or of the Landlord), and such tenant
shall be responsible for all acts of such persons. 
 18. All doors opening onto public corridors shall be kept closed, except when in use
for ingress and egress. 
 19. The requirements of Tenant will be attended to only upon application to the Project Management Office. 

20. Canvassing, soliciting and peddling in the Building are prohibited and each tenant shall report and otherwise cooperate to prevent the
same. 
 21. All office equipment of any electrical or mechanical nature shall be placed by Tenant in the Premises in settings approved by
Landlord, to absorb or prevent any vibration, noise or annoyance. 
 22. No air conditioning unit or other similar apparatus shall be
installed or used by any tenant without the written consent of Landlord. 
 23. There shall not be used in any space, or in the public halls
of the Building, either by any tenant or others, any hand trucks, except those equipped with rubber tires and rubber side guards. 
 24. No
vending machine or machines of any description shall be installed, maintained or operated upon the Premises without the written consent of Landlord. 

25. The scheduling of tenant move-ins shall be subject to the reasonable discretion of Landlord. 

26. If the Tenant desires telephone or telegraph connections, the Landlord will direct electricians as to where and how the wires are to be
introduced. No boring or cutting for wires or otherwise shall be made without direction from the Landlord. 
 27. The term “personal
goods or services vendors” as used herein means persons who periodically enter the Building of which the Premises are a part for the purpose of selling goods or services to a 

  
 C-3 

 
tenant, other than goods or services which are used by the Tenant only for the purpose of conducting its business in the Premises. “Personal goods or services” include, but are not
limited to, drinking water and other beverages, food, barbering services and shoeshining services. Landlord reserves the right to prohibit personal goods and services vendors from access to the Building except upon Landlord’s prior written
consent and upon such reasonable terms and conditions, including, but not limited to, the payment of a reasonable fee and provision for insurance coverage, as are related to the safety, care and cleanliness of the Building, the preservation of good
order thereon, and the relief of any financial or other burden on Landlord or other tenants occasioned by the presence of such vendors or the sale by them of personal goods or services to the Tenant or its employees. If necessary for the
accomplishment of these purposes, Landlord may exclude a particular vendor entirely or limit the number of vendors who may be present at any one time in the Building. 

28. The Building is a non-smoking building. Smoking is prohibited at all times within the entire
Building, including all leased premises, as well as all public/common areas and parking areas for the Building, including any attached parking garage structure. This prohibition applies during business and
non-business hours to restrooms, elevators, elevator lobbies, first floor lobby, stairwells, common hallways, the lunch room and any other public/common area, as well as to all areas within the Leased Premises
by Tenants. Smoking is only permitted in the designated smoking area outside the Building and away from the entrances to the Building. 

29. The Building and Project is a weapons free environment. No tenant, owner of a tenant, officer or employee of a tenant, visitor of tenant,
contractor or subcontractor of tenant, or any other party shall carry weapons (concealed or not) of any kind in the building, or parking areas. This prohibition applies to all public areas, including without limitation, restrooms, elevators,
elevator lobbies, first floor lobby, stairwells, common hallways, all areas within the leased premises of tenants, all surface parking areas and the surrounding land related to the building. 

  
 C-4 

 EXHIBIT D 

FORM TENANT ESTOPPEL CERTIFICATE 
  

					
	TO:	 	  
	  	(“Landlord”)
		 	  
	  	
		 	  
	  	
			
	and:	 		  	
			
		 	  
	  	(“Third Party”)
		 	  
	  	
		 	  
	  	
		
	Re:	 	Property Address:
		 	Lease Date:
		 	Between                                   
                                         
                           , Landlord and
		 	                                    
                                         ,
Tenant
		 	Square Footage
Leased:                                        
                      
		 	Suite
No.                                        
  
		 	Floor:                                   
            

 The undersigned tenant (“Tenant”) hereby certifies to Third Party and Landlord as follows: 

1. The above-described Lease has not been canceled, modified, assigned, extended or amended except
                    . 
 2. Base Rent
has been paid to the first day of the current month and all additional rent has been paid and collected in a current manner. There is no prepaid rent except $            , and the amount of
the security deposit is $            . 
 3. Base Rent is currently payable in
the amount of $             monthly exclusive of Tenant’s Proportionate Share of Operating Expenses. 

4. The Lease terminates
on                     , 20     subject to any renewal option(s) set forth in the Lease. 

5. All work to be performed for Tenant under the Lease has been performed as required and has been accepted by Tenant, except
                    . 
 6. The Lease
is: (a) in full force and effect; (b) to Tenant’s actual knowledge, free from default; and (c) to Tenant’s actual knowledge, Tenant has no claims against the Landlord or offsets against rent. 

7. The Base Year for Operating Expenses, as defined in the said Lease, is
                    . 
 8. The
undersigned has no right or option pursuant to the said Lease or otherwise to purchase all or any part of the Premises or the Building of which the Premises are a part. 

  
 D-1 

 9. There are no other agreements written or oral between the undersigned and the Landlord with
respect to the Lease and/or the Premises and Building. 
 10. The statements contained herein may be relied upon by the Landlord and by any
prospective purchaser of the property of which the Premises is a part and its mortgage lender. 
 If a blank in this document is not filled
in, the blank will be deemed to read “none”. 
 If Tenant is a corporation, the undersigned signatory is a duly appointed Officer
of the corporation. 
  

			
	 Dated this
                     day of                     ,
20    

 
			
		
	 Tenant:
	 	  

		
	 By:
	 	  

	 Name:
	 	  

	 Title:
	 	  

  
 D-2 

 EXHIBIT E 

TENANT’S COMMENCEMENT LETTER 
  

					
	To:	 	  
	  	(“Landlord”)
			
	Date:	 	  
	  	
	  
 Tenant’s Commencement
Letter

  

			
	  
	  	

 The undersigned, as the Tenant under that certain Office Lease (the “Lease”) dated
            , made and entered into between             , a
                     as Landlord, and the undersigned, as Tenant, hereby certifies that: 

 

	 	1.	The Commencement Date of the Lease was                     . 

 

	 	2.	The Expiration Date of the Lease is                     . 

 

	 	3.	The Lease is in full force and effect and has not been modified or amended. 

  

	 	4.	To Tenant’s actual knowledge, Landlord has performed all of its obligations to improve the Premises for occupancy by the undersigned. 

 

	 	5.	TENANT’S FAILURE TO SIGN AND RETURN THIS LETTER (MARKED TO MAKE ACCURATE IF NECESSARY) WITHIN 10 BUSINESS DAYS SHALL BE DEEMED TENANT’S APPROVAL OF THIS LETTER. 

 

			
	 Very truly yours,

 

 
			
	a	 	  

 
			
		
	By:	 	  

	Name:	 	  

	Title:	 	  

  
 E-1 

 EXHIBIT F 

FORM OF LETTER OF CREDIT 

SPECIMEN LANGUAGE ONLY 
 EXHIBIT A

 COMERICA BANK HAS PREPARED THIS SPECIMEN UPON THE REQUEST AND BASED ON THE 

INFORMATION PROVIDED. NO REPRESENTATION AS TO THE ACCURACY OR WILLINGNESS FOR 

COMMITMENT IS MADE BY COMERICA BANK TO ISSUE THIS LETTER OF CREDIT IN THIS OR ANY 

OTHER FORM. WHEN SIGNED, THIS EXHIBIT A WILL BECOME AN INTEGRAL PART OF THE 

CORRESPONDING STANDBY LETTER OF CREDIT APPLICATION AND AGREEMENT. 
  

			
	APPROVED BY: SIENNA BIOPHARMACEUTICALS, INC.	  	

  

									
	APPLICANT’S SIGNATURE	 	  
	 		  	DATE	 	  

 

			
	Beneficiary:	  	Applicant:
	Teachers Insurance and Annuity Association of America	  	Sienna Biopharmaceuticals, Inc.
		  	2945 Townsgate Road, Suite 200
	Attn: Global Real Estate Asset Management	  	Westlake Village, CA 91361
	730 3rd Ave, 14th floor	  	
	New York, NY 10017	  	
		
	 Specimen Date:
 April 26,
2016
	  	 Date and Place of Expiry:
 April 1,
2017 office of Issuing Bank or any automatically extended date, as herein defined.

	Amount:
	USD109,231.20 US DOLLARS: One Hundred Nine Thousand Two
	Hundred Thirty One and 20/100 only

 We hereby open our Irrevocable Standby Letter of Credit no. <<InstrumentID>> in your favor, for account of
Sienna Biopharmaceuticals, Inc. for a sum of USD 109,231.20 (One Hundred Nine Thousand Two Hundred Thirty One and 20/100 U.S. Dollars) available by your draft(s) at sight on Comerica Bank when accompanied by: 

 

	1.	The original of this Irrevocable Standby Letter of Credit and Amendment(s) if any. 

  

	2.	Beneficiary’s statement on its letterhead dated and signed by the Beneficiary, indicating name and title of the signer using either of the wording as follows: 

A. The undersigned hereby certifies that the amount of USD (amount) is being drawn under Comerica Bank’s Standby Letter of Credit no.
<<InstrumentID>> as there has been an uncured default or event of default under one or more of the terms of that certain Office Lease dated (need date) that exists by and between Teachers Insurance and Annuity Association of America (as
“Landlord”) and Sienna Biopharmaceuticals, Inc. (as “Tenant”). 
 or 

B. The undersigned hereby certifies that we have received a written notice of Comerica Bank’s election not to extend their Standby Letter of Credit No.
<<lnstrumentID>> and have not received a replacement Letter of credit or any other financial assurance satisfactory to us from Sienna Biopharmaceuticals, Inc. 

Special Conditions: 
 All signatures must be manually executed
in original. 

  
 F-1 

 All information required whether indicated by blanks, brackets or otherwise, must be completed at the time of
drawing. 
 Partial drawings and multiple presentations may be made under this Irrevocable Standby Letter of Credit, provided, however, that each such
demand that is paid by us shall reduce the amount available under this Irrevocable Standby Letter of Credit. 
 It is a condition of this Irrevocable
Standby Letter of Credit that it shall be deemed automatically extended without amendment for a period of one year from the present or any future expiration date, unless at least thirty (30) days prior to the expiration date we send you notice
by overnight courier that we elect not to extend this Irrevocable Standby Letter of Credit for any such additional period. Said notification will be sent to the address indicated above, unless a change of address is otherwise notified by you to us
in writing by receipted mail or courier. 
 In the event the Letter of Credit is allowed to auto extend on April 1, 2022, the extension period will be
to a final expiration date of July 31, 2022. In no event and without any further notice from ourselves will this Letter of Credit be allowed to extend beyond July 31, 2022. 

This Standby Letter of Credit may be successively transferable in its entirety (but not in part) up to the then available amount in favor of a nominated
Transferee (“Transferee”), assuming such transfer to such Transferee is in compliance with all applicable U.S. laws and regulations. If transferred, this Standby Letter of Credit must be returned to us together with our transfer form
(available upon request), duly executed. We are under no obligation to transfer this Standby Letter of Credit, except to the extent and in the manner expressly consented to by us, and until all charges for the transfer are paid. In case of any
transfer, the draft and any required statement must be executed by the Transferee and where the Beneficiary’s name appears within this Standby Letter of Credit, the Transferee’s name is automatically substituted therefore. At the time of
the transfer request, the original of this Standby Letter of Credit and any amendment(s) thereto must be provided. Comerica Bank will not assume or undertake any liability or responsibility for verifying, validating or authenticating the authority
or rights of any party(ies) requesting the transfer of this Letter of Credit or executing any document(s) in connection therewith. 
 All fees relating to
this Letter of Credit, including any and all transfer related costs shall be paid by the Applicant. 
 Notwithstanding any preprinted wording to the
contrary on our standard transfer form, payment of all transfer fees is for the Applicant’s account. 
 All drafts required under this Irrevocable
Standby Letter of Credit must be marked: “Drawn under Comerica Bank Irrevocable Standby Letter of Credit no. <<InstrumentID>>.” 
 In
the case of cancellation, the original Standby Letter of Credit and all Amendments thereto must be returned to us together with a written request from Beneficiary referencing this Standby Letter of Credit number and authorizing its cancellation.

 All documents are to be dispatched in one lot by courier service to Comerica Bank International Trade Services, 2321 Rosecrans Ave., 5th fl. El Segundo,
CA 90245, Attn: Standby Letter of Credit Dept. 
 This Irrevocable Standby Letter of Credit sets forth in full the terms of our undertaking and such
undertaking shall not be in any way modified, amended or amplified by reference to any document, instrument or agreement referred to herein or in which this Irrevocable Standby Letter of Credit is referred to or to which this Irrevocable Standby
Letter of Credit relates, and any such reference shall not be deemed to incorporate herein by reference any document, instrument or agreement. 
 We hereby
engage with you that all drawing(s) made under and in compliance with the terms of this Irrevocable Standby Letter of Credit will be duly honored if drawn and presented for payment at our office located at Comerica Bank International Trade Services,
2321 Rosecrans Ave., 5th fl., El Segundo, CA 90245, Attn: Standby Letter of Credit Dept. on or before the expiration date of this Standby Letter of Credit, or any automatically extended date. Presentation for payment may also be made by Beneficiary
on or before the expiration date of this Standby Letter 

  
 F-2 

 
of Credit via facsimile transmission at: (310) 297-2885; and simultaneously under telephone advice to: (310)
297-2858 or (310) 297-2840, attention: Standby Letter of Credit No. <<InstrumentID>>, with originals to follow by overnight courier service;
provided, however, we will determine honor or dishonor on the basis of presentation by facsimile alone, and will not examine the originals. 
 Except so far
as otherwise expressly stated herein, this Standby Letter of Credit is subject to the “International Standby Practices” (ISP 98) International Chamber of Commerce (Publication No. 590). 

END OF SPECIMEN FORMAT 

  
 F-3 

 EXHIBIT G 

JANITORIAL SPECIFICATIONS 

CLEANING SCHEDULE 
 OFFICE AREAS:

 NIGHTLY SERVICES – FIVE (5) NIGHTS PER WEEK 
  

	•	 	Empty wastebaskets, ashtrays and other trash receptacles. Ashtrays are to be wiped clean. Trash is to be removed from building to designated pick-up area. 

 

	•	 	All chairs and wastebaskets to be returned to proper position after cleaning. 

  

	•	 	Dust mop all composition floors with specially treated dust mops. 

  

	•	 	Vacuum carpets. 

  

	•	 	Thoroughly dust desks, office furniture and office accessories. Desk-top papers, desk
accessories are not to be moved. 

  

	•	 	Remove fingerprints, soil smudges from doors, door frames and wall-switch plates. 

  

	•	 	Spot-clean entrance door glass and all partition glass. 

  

	•	 	Clean glass desk tops. Desk tops must be completely cleared of
all papers. 

 PUBLIC AREAS: 

NIGHTLY SERVICES – FIVE (5) NIGHTS PER WEEK 
  

	•	 	Clean, polish and sanitize drinking fountains. 

  

	•	 	Dust-mop all composition floors with specially treated dust mop. Damp-mop and buff, as necessary. 

 

	•	 	Thoroughly vacuum all corridor carpets. 

  

	•	 	Remove fingerprints, soil smudges from doors, door frames and wall-switch plates. 

  

	•	 	Empty wastebaskets, ashtrays and other trash receptacles. Ashtrays are to be wiped clean. Trash is to be removed from building to designated pick-up area. (Trash removal from
building to be provided by outside trash-removal vendor.) 

  

	•	 	Spot-clean entrance door glass and all partition glass. 

  

	•	 	Clean and polish elevator doors and control panels. Thoroughly clean inside of elevator cabs. Vacuum door tracks and saddles. 

  

	•	 	Sand jars to be wiped clean and fine-screened. 

  
 G-1 

	•	 	Spot-mop traffic areas for spillage. 

  

	•	 	Police all outside entrance-ways to building lobby. 

 OFFICE AND
PUBLIC AREAS: 
 WEEKLY SERVICES – ONCE PER WEEK 
  

	•	 	Completely dust all low-reach areas, chair rungs and inside of door jambs. 

  

	•	 	Completely dust window sills, window ledges, door louvers and wood paneling modeling, handrails and railings. 

  

	•	 	Dust levelor blinds where applicable. 

  

	•	 	Clean and polish entrance door metal and thresholds. 

  

	•	 	Clean fire extinguishers and/or fire hose cabinets; dust and clean cabinet glass. 

  

	•	 	Remove all spots, smudges, and marks from doors, partitions, walls, woodwork, window frames, mullions and ledges, wall switches and outlet plugs on floors and walls. 

 

	•	 	Police all stairways throughout building. 

  

	•	 	Clean all baseboards. 

  

	•	 	Clean and sanitize telephones. 

 MONTHLY SERVICES – ONCE PER MONTH 

 

	•	 	Dust all high-reach areas; door frames, door tops and partitions. 

  

	•	 	Dust all picture moldings, frames and blinds. 

  

	•	 	Clean fire extinguishers and/or fire hose cabinets; dust and clean cabinet glass. 

 RESTROOM SERVICE:

 NIGHTLY SERVICES – FIVE (5) NIGHTS PER WEEK 
  

	•	 	Empty wastebaskets and sanitary napkin receptacles. 

  

	•	 	Refill toilet tissue, paper towel, seat-cover, soap and sanitary napkin dispensers. 

  

	•	 	Wash, rinse and wipe dry all lavatory and lavatory fixtures. 

  

	•	 	Clean and polish all metalwork. 

  

	•	 	Thoroughly clean and disinfect toilets; top and bottom. 

  

	•	 	Thoroughly clean toilet bowls and urinals; removing stains – keep free of scale. 

  

	•	 	Mop floors with a germicidal solution. 

  
 G-2 

 WEEKLY SERVICES 
  

	•	 	Dust ops of partitions and wainscoting. 

  

	•	 	Wash down urinal screens and adjacent tile. 

 MONTHLY SERVICES 

 

	•	 	Dust walls and ceiling vents. 

  

	•	 	Scrub floors with a special germicidal solution. 

  

	•	 	Thoroughly wipe down all the walls and partitions. 

  

	•	 	Spot-clean walls around lavatories. 

  

	•	 	De-scale toilets and urinals. 

 QUARTERLY SERVICES – ONCE EVERY
THREE MONTHS 
  

	•	 	Pour clean water down floor drains to prevent sewer gas from escaping. 

  

	•	 	Thoroughly clean all soap dispenser nozzles. 

 FLOOR SERVICES: 

 

	•	 	Damp mop hard-surface lobby floors – Nightly. 

  

	•	 	Clean and refinish all hard-surface floors – Monthly. 

MISCELLANEOUS SERVICES: 
  

	•	 	All cleaning personnel will be instructed to immediately report any damages, plumbing problems, etc. which they encounter during cleaning to the Crew Supervisor. 

 

	•	 	All designated lights will be turned off – Nightly. 

  

	•	 	Janitor’s storage closet and all building service areas will be kept in a neat and orderly condition at all times. 

  

	•	 	Interior windows are cleaned once per year and exterior windows are cleaned two (2) times per year. 

  
 G-3 

 EXHIBIT H 

RESERVED PARKING 
  

 

  
 H-1 

 ADDENDUM ONE 

(BASEBALL ARBITRATION) 

ONE RENEWAL OPTION AT MARKET 

(a) Provided that as of the time of the giving of the Extension Notice and the Commencement Date of the Extension Term, (i) Tenant is the
Tenant originally named herein or an occupant pursuant to a Permitted Transfer, (ii) Tenant and Affiliates actually collectively occupy at least seventy-five percent (75%) of the Premises initially
demised under this Lease and any space added to the Premises, and (iii) no event of default exists beyond applicable notice and cure periods; then Tenant shall have the right to extend the Lease Term for an additional term of three
(3) years (such additional term is hereinafter called the “Extension Term”) commencing on the day following the expiration of the Lease Term (hereinafter referred to as the “Commencement Date of the Extension
Term”). Tenant shall give Landlord notice (hereinafter called the “Extension Notice”) of its election to extend the term of the Lease Term at least nine (9) months, but not more than twelve (12) months, prior to
the scheduled expiration date of the Lease Term. 
 (b) The Base Rent payable by Tenant to Landlord during the Extension Term shall be the
Fair Market Rent, as defined and determined pursuant to Paragraph (c), Paragraph (d), and Paragraph (e) below. 

(c) The term “Fair Market Rent” shall mean the net (including reducing such rate if market concessions are not actually being
granted to Tenant) market rental rate for the Premises or other applicable space (determined by reference to comparable space in the Project and in comparable suburban office buildings within a one-mile radius
of the Project) that would be payable by a willing tenant to a willing landlord, neither being under any compulsion to act, in equal monthly payments during a term equal to the applicable term and commencing on the first day of the applicable term
thereof (taking into consideration all pertinent factors, including, without limitation, the length of term, use, quality of services provided, size of space, location of the space within the building, definition of net rentable area, condition of
the space, leasehold improvements or tenant improvement allowance provided, quality, age, and location of the applicable building, tenant clientele of the building, financial strength of the applicable tenant, any applicable reductions arising from
rental concessions and abatements, method for computing and the amount of Operating Expenses and granting Tenant a 2019 Base Year, taxes, and other expenses payable by tenants, parking, allowances, concessions and amenities (and any related charge)
and the time the particular rate under consideration becomes effective, all to the same extent and in the same manner as the rental marketplace takes such factors into account). In addition to its obligation to pay Base Rent (as determined herein),
Tenant shall continue to pay and reimburse Landlord as set forth in the Lease with respect to such Operating Expenses (subject to new Base Year) and other items with respect to the Premises during the Extension Term. 

(d) Landlord shall notify Tenant of its determination of the Fair Market Rent (which shall be made in Landlord’s sole discretion) for the
Extension Term, and Tenant shall advise Landlord of any objection within ten (10) business days of receipt of Landlord’s notice. Failure to respond within the ten (10) business day period shall constitute Tenant’s acceptance of
such Fair Market Rent. If Tenant objects, Landlord and Tenant shall commence negotiations to attempt to agree upon the Fair Market Rent within thirty (30) days of Landlord’s receipt of Tenant’s notice. If the parties cannot agree,
each acting in good faith but without any obligation to agree, then the Lease Term shall not be extended and shall terminate on its scheduled termination date and Tenant shall have no further right hereunder or any remedy by reason of the
parties’ failure to agree unless Tenant or Landlord invokes the arbitration procedure provided below to determine the Fair Market Rent. 

(e) Arbitration to determine the Fair Market Rent shall be in accordance with the Real Estate Valuation Arbitration Rules of the American
Arbitration Association. Unless otherwise required by state law, arbitration shall be conducted in the metropolitan area where the Project is located by a single arbitrator unaffiliated with either party who shall be a broker or appraiser with at
least ten (10) years of brokerage or 

  
 Addendum One - 1 

 
appraisal experience, as applicable, in the area of the Project. Either party may elect to arbitrate by sending written notice to the other party and the Regional Office of the American
Arbitration Association within five (5) days after the thirty (30) day negotiating period provided in Paragraph (d), invoking the binding arbitration provisions of this paragraph. Landlord and Tenant shall each submit to the
arbitrator their respective proposal of Fair Market Rent. The arbitrator must choose between the Landlord’s proposal and the Tenant’s proposal and may not compromise between the two or select some other amount. The cost of the arbitration
shall be paid by Landlord if the Fair Market Rent is that proposed by Tenant and by Tenant if the Fair Market Rent is that proposed by Landlord; and shall be borne equally otherwise. If the arbitrator has not determined the Fair Market Rent as of
the end of the Lease Term, Tenant shall pay one hundred five percent (105%) of the Base Rent in effect under the Lease as of the end of the Lease Term until the Fair Market Rent is determined as provided herein. Upon such determination, Landlord and
Tenant shall make the appropriate adjustments to the payments between them. 
 (f) The parties consent to the jurisdiction of any
appropriate court to enforce the arbitration provisions of this Addendum One and to enter judgment upon the decision of the arbitrator. 

(g) Except for the Fair Market Rent as determined above, Tenant’s occupancy of the Premises during the Extension Term shall be on the
same terms and conditions as are in effect immediately prior to the expiration of the initial Lease Term; provided, however, Tenant shall have no further right to extend the Lease Term pursuant to this Addendum One or to any allowances, credits or
abatements or any options to expand, contract, terminate, renew or extend the Lease. 
 (h) If Tenant does not give the Extension Notice
within the period set forth in Paragraph (a) above, Tenant’s right to extend the Lease Term shall automatically terminate. Time is of the essence as to the giving of the Extension Notice and the notice of Tenant’s objection
under Paragraph (d). 
 (i) Landlord shall have no obligation to refurbish or otherwise improve the Premises for the Extension Term
except as determined pursuant to the Fair Market Rent. The Premises shall be tendered on the Commencement Date of the Extension Term in “as-is” condition. 

(j) If the Lease is extended for the Extension Term, then Landlord shall prepare and Tenant shall execute an amendment to the Lease confirming
the extension of the Lease Term and the other provisions applicable thereto (the “Amendment”). 
 (k) If Tenant exercises
its right to extend the term of the Lease for the Extension Term pursuant to this Addendum One, the defined term “Lease Term” as used in the Lease, shall be construed to include, when practicable, the Extension Term except as provided in
Paragraph (g) above. 

  
 Addendum One - 2

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