Document:

1 August 2000

Mr. Charles C. Harwood, Jr.

[Address intentionally left blank]

         Re:      AMENDED AND RESTATED EMPLOYMENT LETTER AGREEMENT (THE "AMENDED
                  AND RESTATED AGREEMENT")

Dear Charlie:

We would like to offer you the new position as Corporate Senior Vice President,
Venture Development, of Covance Inc. ("Covance" or the "Company"). As this new
position will require a modification of duties and responsibilities as more
fully set forth below, we would like to amend and restate your Employment Letter
Agreement, dated November 20, 1996, to incorporate the terms of Amendment No. 1
to the Employment Letter Agreement, dated November 20, 1998 (the Employment
Letter Agreement together with Amendment No. 1, the "Former Agreement") and
incorporate the terms of the letter, dated May 25, 2000 (the "Letter Agreement")
setting forth the terms of your new position. This Amended and Restated
Agreement sets forth our mutually agreed upon terms of employment. Therefore, in
consideration of the premises and covenants herein contained, we hereby agree as
follows:

TERM

This Amended and Restated Agreement will be effective as of June 1, 2000 and
will terminate on June 1, 2001 (the "Term"), unless renewed by mutual agreement
of the parties.

POSITION

As Corporate Senior Vice President, Venture Development, of Covance, your duties
over the next twelve months will entail working toward achieving the goals
specified on Schedule A attached hereto (the "Goals").

You may also be required to perform such other duties as may be incidental
thereto. You will report to the CEO or his designee.

BASE SALARY

Your base salary during the Term will be $239,148 (payable on the normal
semimonthly payroll cycle for Corporate employees).

ANNUAL BONUS

You are entitled to participate in the Covance Way Annual Incentive Plan (the
"Bonus Plan") for the 2000 plan year. The Bonus Plan provides that upon
satisfaction of certain financial goals for Covance established by the Covance
Board of Directors, you shall receive an annual target incentive of $130,488
(the "2000 Target Bonus Incentive"), which is equal to 55% of your annualized
base salary of $237,250 (1/1/00 through 2/29/00 at $227,760 per year and 3/1/00
through 12/31/00 at $239,148 per year).
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Your bonus payout for 2000 will be calculated as the product of three factors,
(i) the 2000 Target Bonus Incentive, (ii) a corporate pool factor of 75% and
(iii) an individual performance factor of between zero and 200%. Your annual
bonus calculation will utilize a 100% individual performance factor for the
period beginning January 1, 2000 through May 31, 2000. For the period beginning
June 1, 2000 through December 31, 2000, your individual performance factor will
be based on your personal performance measured against attainment of the Goals,
as determined by the CEO. Thus your 2000 bonus payout under the Bonus Plan will
be the sum of (a) the 2000 Target Bonus Incentive times 75% times 100% times
5/12 or $40,777.50 for the first 5 months of 2000 and (b) the 2000 Target Bonus
Incentive times 75% times 7/12 times your individual performance factor for the
last 7 months of 2000. Your 2000 bonus will be paid in cash by March 15, 2001 so
long as you have not voluntarily left Covance by that date.

You will not be eligible to participate in the 2001 Bonus Plan.

SPECIAL GOAL BONUSES

You shall be entitled to earn the following Special Goal Bonuses during the
Term:

        1.    In the event you use your best efforts to complete the Goals as
              specified herein (regardless of actual achievement of the Goals),
              you will be entitled to receive an additional bonus payment equal
              to $450,000.

        2.    You will be entitled to receive additional bonus payments equal to
              $300,000 in the aggregate upon satisfaction of certain goals set
              forth on Schedule B attached hereto.

Each Special Goal Bonus you earn, if any, will be payable to you in a cash lump
sum payment within 30 days following the end of the Term. Each Special Goal
Bonus paid to you will be deemed "Plan Compensation" for purposes of the
Supplemental Executive Retirement Plan ("SERP"), as such term is defined in the
SERP.

PENSION, INVESTMENT AND BENEFIT PLANS

During the Term, you will continue to be entitled to participate in the Covance
plans in which you currently participate (e.g., medical, dental, disability,
life insurance, SERP, 401(k) savings plan, ESOP, employee stock purchase plan)
in accordance with the terms and conditions of those plans.

AUTO AND FINANCIAL COUNSELING ALLOWANCE

You will continue to receive a gross monthly auto allowance of $1,070 per month.
In addition, you will also be entitled to participate in other perquisites
and/or benefits programs as are offered to all other senior executives of
Covance as a class. These include a tax/financial counseling allowance of $6,000
per year under the terms of the Covance plan. Any expenses actually incurred
under this plan will be grossed up for tax purposes at an incremental income tax
rate of 45%.

FUTURE EQUITY AWARDS

You may be awarded from time to time additional compensation (such as stock
options or restricted stock) pursuant to Covance's Employee Equity Participation
Program or any additional or replacement incentive compensation or long-term
compensation program established by Covance for its senior officers. Any awards
under such programs, except as provided below, shall be at such levels or in
such amounts as Covance's Board of Directors deems, in its sole discretion,
appropriate for your position and the performance of your duties.

SEVERANCE FOR TERMINATION OF EMPLOYMENT DURING THE TERM

Except as provided below under the paragraph headed "CHANGE-OF-CONTROL", Covance
guarantees that should you be involuntarily terminated for reasons other than
for Cause, you will receive an amount equal to the sum of (a) two years base
salary (payable on the normal semimonthly payroll cycle) determined at the time
of termination, (b) two years of the annual incentive bonus (payable on the
normal bonus cycles) in an amount equal for each such year to the product of
your base salary in effect at termination and 55% (the sum of (a) and (b) being,

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collectively, the "Termination Payments"), (c) the Special Goal Bonuses totaling
$750,000 (payable within 30 days of termination) and (d) the 2000 Target Bonus
Incentive of $130,488 (payable within 30 days of termination), if the 2000 bonus
has not already been paid. Any payments under (c) and (d) will be deemed "Plan
Compensation" for purposes of the Supplemental Executive Retirement Plan
("SERP"), as such term is defined in the SERP. In addition, for purposes of
benefit accrual and vesting determination purposes under the SERP, you will be
credited with two additional "Years of Service" (as such term is defined under
the SERP). You will also have a period of three years from the date of
termination to exercise any outstanding Covance stock options that are vested as
of the date of termination.

"Cause" shall mean (i) your convictions of a felony or a misdemeanor if such
misdemeanor involves moral turpitude; (ii) your committing any act of gross
negligence or intentional misconduct in the performance or non-performance of
your duties as an employee of Covance or its affiliates, including, any actions
which constitute sexual harassment under applicable laws, rules or regulations;
(iii) your failure to perform your duties assigned for a period of thirty (30)
or more days unless such failure is caused by an Extended Disability; or (iv)
misappropriation of assets, personal dishonesty or intentional misrepresentation
of facts which may cause Covance or its affiliates financial or reputational
harm.

Should such involuntary termination occur because of an Extended Disability, and
not for any other reason that constitutes Cause, for 120 consecutive days where
you have not returned to your duties on a full-time basis after the expiration
of such 120 day period within 30 days after written notice of termination is
given to you, Covance shall pay to you (a) the Termination Payments at the times
specified above, (b) a prorata portion of the $450,000 Special Goal Bonus based
upon the percentage of the Term elapsed through the date of termination (payable
within 30 days of termination), (c) a prorata portion of the 2000 Target Bonus
Incentive of $130,488, if the 2000 bonus has not already been paid, based upon
the percentage of calendar year 2000 elapsed through the date of termination
(payable within 30 days of termination), and (d) any other Special Goal Bonus,
other than (b) above, that has been achieved as of the date of termination
(payable within 30 days of termination). Any payments under (b), (c) and (d)
will be deemed "Plan Compensation" for purposes of the SERP, as such term is
defined in the SERP.

"Extended Disability" shall (i) mean you are unable, as a result of a medically
determinable physical or mental impairment, to perform the duties and services
of your position, or (ii) have the meaning specified in any disability insurance
policy maintained by Covance, whichever is more favorable to you.

Except as may be otherwise provided in applicable Covance compensation and
benefit plans, Covance shall not be liable for any salary or benefit payments to
you beyond the date of your voluntary termination of employment with Covance. In
the event of a termination of employment for Cause or Extended Disability, you
shall not be entitled to any compensation or other benefits not already earned
and owing to you on account of your services on the date of such termination of
employment except as provided above with respect to a termination for Extended
Disability.

Medical, dental, and life insurance will be continued, to the extent they are
not otherwise prohibited under the respective plans, while you are receiving the
Termination Payments.

CHANGE-OF-CONTROL

In the event of a Change-of-Control (as defined below), your employment with
Covance will be deemed to have been involuntarily terminated as of the day after
the date of the Change-of-Control and you will be entitled to a lump sum payment
equal to the sum of (1) the product of (a) 3 and (b) your base annual salary in
effect at the time of the Change-of-Control and (2) the product of (a) 3 and (b)
number that is 55% of your base annual salary in effect at the time of the
Change-of-Control (the sum of (1) and (2) being, collectively, the
"Change-of-Control Payment"). In addition, you will be entitled to a lump sum
payment equal to the sum of (A) the Special Goal Bonuses totaling $750,000 and
(B) the 2000 Target Bonus Incentive of $130,458, if the 2000 Bonus has not
already been paid, and such payment of (A) plus (B) will be deemed "Plan
Compensation" for purposes of the SERP, as such term is defined in the SERP. All
of the abovementioned payments will be made within 30 days of the date of a
Change-of-Control. In addition to, and as a result of, the foregoing (i) all of
your stock options, restricted stock, deferred compensation and similar benefits
which have not become vested on the date of a Change-of-Control shall become
vested upon such event and you will have a period of three years from the date
of termination to exercise any outstanding Covance stock options that are vested
as of the date of termination, (ii) you shall be entitled to receive any
payments calculated pursuant to the paragraph headed "CERTAIN ADDITIONAL
PAYMENTS BY COVANCE", and (iii) for purposes of benefit accrual and vesting
determination purposes under the SERP, you will be deemed to have been
involuntarily terminated during the three-year period following the
Change-of-Control.

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For purposes of this Agreement, a "Change-of-Control" is defined to occur when:

        (i)     any person (including as such term is used in Section 13(d) and
14(d)(2) of the Securities Exchange Act of 1934) becomes the beneficial owner,
directly or indirectly, of Covance's securities representing 20% or more of the
combined voting power of Covance's then outstanding securities; or

        (ii)    as a result of a proxy contest or contests or other forms of
contested shareholder votes (in each case either individually or in the
aggregate), a majority of the individuals elected to serve on Covance's Board of
Directors are different than the individuals who served on Covance's Board of
Directors at any time within the two years prior to such proxy contest or
contests or other forms of contested shareholder votes (in each case either
individually or in the aggregate); or

        (iii)   Covance shareholders approve a merger, or consolidation (where
in each case Covance is not the survivor thereof), or sale or disposition of all
or substantially all of Covance's assets or a plan or partial or complete
liquidation; or

        (iv)    an offeror (other than Covance) purchases shares of Covance
common stock pursuant to a tender or exchange offer for such shares.

In the event you are involved in any dispute about your rights under this
Agreement arising on or after a Change-of-Control, Covance shall pay all legal
costs and fees incurred by you in connection with such dispute promptly upon
receipt of any invoice relating thereto.

The benefits set forth under the paragraph headed "AUTO AND FINANCIAL COUNSELING
ALLOWANCE" and medical, dental, and life insurance will be continued, to the
extent they are not otherwise prohibited under the respective plans, until you
find other employment but not longer than three years from the date of the
Change-of-Control.

SEVERANCE FOR TERMINATION OF EMPLOYMENT FOLLOWING THE EXPIRATION OF THE TERM

Unless otherwise mutually agreed to by the parties hereto this Agreement shall
terminate on June 1, 2001. At that time, Covance may offer you continued
employment with the Company, the terms of which shall be agreed upon by you and
Covance at that time. In the event either (i) Covance does not continue to
employ you with the Company or (ii) Covance does continue to employ you with the
Company but you choose not to, you shall be entitled to receive severance
payments equal to the Termination Payments you would receive if you were
involuntarily terminated for reasons other than for Cause by the Company as set
forth above under the paragraph headed "SEVERANCE FOR TERMINATION OF EMPLOYMENT
DURING THE TERM." Such Termination Payments shall be in addition to any Special
Goal Bonuses specified in this Agreement which have been earned but not paid. In
addition, for purposes of benefit accrual and vesting determination purposes
under the SERP, you will be credited with two additional "Years of Service" (as
such term is defined in the SERP). You will also have a period of three years
from June 1, 2001 to exercise any outstanding Covance stock options that are
vested as of May 31, 2001. Any outstanding unvested options will be forfeited on
June 1, 2001.

Medical, dental, and life insurance will be continued, to the extent they are
not otherwise prohibited under the respective plans, while you are receiving the
Termination Payments.

CERTAIN ADDITIONAL PAYMENTS BY COVANCE

        (a) Anything in this Agreement to the contrary notwithstanding, in the
event it shall be determined that any payment or distribution by, to or for the
benefit of you, whether made under this Agreement or otherwise (a "Payment"),
would be subject to the excise tax imposed by Section 4999 of the Internal
Revenue Code of 1986, as amended (the "Excise Tax"), then you shall be entitled
to receive an additional payment (a "Gross-Up Payment") in an amount such that
after payment by you of all taxes (including any Excise Tax) imposed upon the
Gross-Up Payment, you retain an amount of the Gross-Up Payment equal to the
Excise Tax imposed upon the Payments.

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        (b) All determinations required to be made under these provisions,
including whether a Gross-Up Payment is required and the amount of such Gross-Up
Payment, shall be made by the accounting firm utilized by Covance for the
preparation of its annual external financial statements (the "Accounting Firm")
which shall provide detailed supporting calculations both to Covance and you
within 30 days of the Change-of-Control, if applicable, or such earlier time as
is requested by Covance. The Gross-Up Payment, if any, as determined pursuant to
this Paragraph (b), shall be paid to you within 10 days of the receipt of the
Accounting Firm's determination. Any determination by the Accounting Firm shall
be binding upon Covance and you. If subsequent final determinations of the
Excise Tax made by the Internal Revenue Service give rise to additional Excise
Tax, then additional Gross-Up Payments shall be made by Covance to you within 10
days after the notice is received by Covance of such final determination.

        (c) You shall notify Covance in writing of any claim by the Internal
Revenue Service that, if successful, would require the payment by Covance of a
Gross-Up Payment. Such notification shall be given as soon as practicable but no
later than 10 business days after you know of such claim. You shall not pay such
claim prior to the expiration of the thirty-day period following the date on
which you give such notice to Covance (or such shorter period ending on the date
that any payment of taxes with respect to such claim is due). If Covance
notifies you in writing prior to the expiration of such period that it desires
to contest such claim, you shall:

            (i)    give Covance any information reasonably requested by Covance
        relating too such claims,

            (ii)   take such action in connection with contesting such claims as
        Covance shall reasonably request in writing from time to time,
        including, without limitation, accepting legal representation with
        respect to such claim by an attorney selected by Covance,

            (iii)  cooperate with Covance in good faith in order effectively to
        contest such claim, and

            (iv)   permit Covance to participate in any proceedings relating to
        such claim;

PROVIDED, however, that Covance shall bear all costs and expenses incurred in
connection with such contest and shall indemnify and hold you harmless, on an
after-tax basis, for Excise Tax or income tax imposed as a result of such
contest or representation and payment of costs and expenses. Covance shall
control all proceedings taken in connection with such contents. Covance may, at
its sole option, either direct you to pay the tax claimed and sue for a refund
or contest the claim in any permissible manner, and you agree to prosecute such
contest to a determination before any administrative tribunal, in a court of
initial jurisdiction and in one or more appellate courts, as Covance shall
determine; PROVIDED, HOWEVER, that if Covance directs you to pay such claim and
sue for a refund, Covance shall advance the amount of such payment to you on an
interest-free basis and shall indemnify and hold you harmless, on an after-tax
basis, from any Excise Tax or income tax imposed with respect to such advance.

        (d) If, after the receipt by you of an amount advanced by Covance
pursuant to Paragraph (c), you become entitled to receive any refund with
respect to such claim, you shall promptly pay to Covance the amount of such
refund (together with any interest paid or credited thereon after taxes
applicable thereto). If, after the receipt by you of an amount advanced by
Covance pursuant to Paragraph (c), a final determination is made that you shall
not be entitled to any refund with respect to such claim, then such advance
shall be forgiven and shall not be required to be repaid and the amount of such
advance shall offset the amount of Gross-Up Payment required to be paid.

LOCATION

Your principal office location during the Term will be at your residence in
[city and state intentionally omitted]. You will work at the Princeton, NJ
office, other Covance locations and travel as is reasonable to perform your
duties.

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CONFIDENTIALITY

Covance possesses and will continue to possess trade secrets or other
information which has been created, discovered, developed by or otherwise become
known to Covance, or in which property rights have been assigned or otherwise
conveyed to Covance, which information has commercial value with respect to the
business and operations of Covance or the business and operations of its
subsidiaries or its affiliates, including, but not limited to, information
regarding sales, costs, customers, employees, products, services, apparatus,
equipment, processes, formulae, marketing, or the organization, business or
finances of Covance or its subsidiaries or its affiliates, or any information
you have reason to know Covance would like to treat as confidential for any
purpose, such as maintaining a competitive advantage or avoiding undesirable
publicity, whether or not developed by you ("Confidential Information"). Unless
previously authorized in writing or instructed in writing by Covance, you will
not, from and after the date of employment with Covance, directly or indirectly,
use for your own benefit or purposes, or disclose to, or use for the benefit or
purposes of, anyone other than Covance or its subsidiaries or affiliates, any
Confidential Information, unless and until, and then only to the extent that,
such Confidential Information has (a) been or becomes published, or is or
becomes generally known in the trade through no fault of you, or (b) such
information is made known and available to you by a third party, who, by such
disclosure to you does not breach any duty or obligation to Covance or its
subsidiaries or affiliates.

In the event you become legally compelled to disclose any of the Confidential
Information, you will provide Covance with prompt notice so that Covance may
seek a protective order or other appropriate remedy and/or waive compliance with
the provisions of this Agreement. If, in the absence of a protective order or
the receipt of a waiver hereunder, you are nonetheless legally required to
disclose Confidential Information to any tribunal or else stand liable for
contempt or suffer other censure or penalty, you may disclose such Confidential
Information to such tribunal without liability hereunder.

Upon termination of your employment with Covance, you will deliver to Covance
all written embodiments of the Confidential Information, including all notes,
drawings, records, reports, pertaining to work done by you during your
employment with Covance and all other matters of secret or confidential nature
relating to Covance's business.

NON-COMPETITION

You acknowledge that the services to be rendered by you to Covance are of a
special and unusual character, with a unique value to Covance, the loss of which
cannot adequately be compensated by damages or an action at law. In view of the
unique value to Covance of such services for which you are employed at Covance,
because of the Confidential Information obtained by, or disclosed to you, and as
a material inducement to Covance to compensate you as well as provide you with
additional benefits and other good and valuable consideration, you covenant and
agree that:

        (a) Unless authorized by Covance's Board of Directors in writing, you
shall not, during your employment with Covance and for one year after the
expiration of your employment with Covance (the "Post Employment Term", your
employment with Covance and the Post Employment Term, being, collectively, the
"Period"), become employed by, become a director, officer, shareholder or
partner of, or to otherwise enter into, conduct, or advise any business, whether
directly or indirectly, which offers services or products in the United States
and any other geographical regions where Covance, or its subsidiaries or its
affiliates, is then offering its services or products in competition with
services or products sold by Covance, or its subsidiaries or its affiliates at
any time during the Period in the United States or such region, including,
without limitation, the conduct of contract pre-clinical toxicology laboratory
services, contract biopharmaceutical clinical laboratory services, contract
bioprocessing or manufacturing services, contract drug packaging services, Phase
I, II, III or IV clinical studies or outcomes or disease management studies
(collectively, the "Covance Services"), unless any of such services have been
substantially divested by Covance; PROVIDED that you shall not be bound by the
restrictions contained in this provision (a) unless Covance has made all
payments to you which are due and owing to you under this Agreement or any plan
or bonus or incentive plan of Covance, including any equity incentive or bonus
incentive plan of Covance, or otherwise; PROVIDED, FURTHER, that if you have
been dismissed by Covance for Cause or you have voluntarily terminated your
employment with Covance for any reason or no reason, you shall not be bound by
the foregoing provisions of this paragraph (a) during the Post Employment Term
unless Covance has made to you the payments specified above under the paragraphs
headed "SEVERANCE FOR TERMINATION OF EMPLOYMENT DURING THE TERM" or "SEVERANCE
FOR TERMINATION OF EMPLOYMENT FOLLOWING THE EXPIRATION OF THE TERM", whichever
is applicable. Nothing herein shall restrict you in your employment in any
capacity by a corporation or entity engaged substantially in the manufacture or
sale of pharmaceuticals, or any other business which does not offer Covance
Services on a contract basis as a substantial amount of its economic activity.

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Ownership of not more than 1% of the issued and outstanding shares of any class
of securities of a corporation, the securities of which are traded on a national
securities exchange or in the over-the-counter market, shall not cause you to be
deemed a shareholder under this provision.

        (b) During the Period, you shall not, directly or indirectly, solicit,
divert or accept any business from any customer of Covance, its subsidiaries or
affiliates to the detriment of any of the foregoing or seek to cause any such
customers to refrain from doing business with or patronizing Covance, its
subsidiaries or its affiliates.

        (c) During the Period, you shall not, directly or indirectly, solicit or
induce for employment any employee of Covance or any of its subsidiaries or
affiliates or otherwise encourage any employee of Covance or any of its
subsidiaries or affiliates to leave Covance, or any of its subsidiaries or
affiliates. For purposes of this Agreement, advertisements in trade magazines,
use of executive search firms and other conventional means of obtaining
employees shall not be construed as solicitation, inducements or encouragement
unless the party utilizing such conventional means specifically directs the
efforts at employee(s) with whom the party may not have contact pursuant to the
terms of this Agreement.

        (d) For purposes of this Agreement, the term "directly or indirectly"
shall be construed in its broadest sense and shall include the activities of the
members of your members of your immediate family or any partnership, or as
otherwise specified above, and the term "customer" shall mean any person or
entity to which Covance has sold services during the one-year period prior to
the date you ceased employment with Covance or any persons or entities targeted
by Covance or contacted for the purpose of selling such services during such
one-year period which you knew about or reasonably should have known about.

OWNERSHIP OF KNOW-HOW, INVENTIONS AND OTHER INTELLECTUAL PROPERTY

All the know-how, innovations, inventions, discoveries, improvements,
procedures, programs, formulas and specifications which have been or may be
either, directly or indirectly, developed, conceived or made by you in
connection with your employment with Covance, whether or not in concert with
other employees or shown or delivered to Covance or any of its subsidiaries or
its affiliates, and whether or not they are eligible for patent, copyright,
trademark, trade secret or other legal protection, shall be the exclusive
property of Covance and you shall, at Covance's request and expense, promptly
execute any and all documents or instruments which may be necessary to evidence
such ownership.

Obligations of this Agreement cover any and all inventions, discoveries or
improvements, directly or indirectly, conceived or made by you in connection
with your employment with Covance prior to the date of this Agreement.

You will communicate to Covance promptly and fully all improvements and
inventions you make or conceive (either solely or jointly with others) during
the period of your employment with Covance and conceived by you during the Post
Employment Term if based on or related to your employment at Covance.

PATENTS

You will, during and after the Period, at Covance's request and expense but
without additional compensation, assist Covance and its nominees in every proper
way to obtain and to vest in Covance or its nominees, title to patents on such
improvements and inventions in all countries, by executing all necessary or
desirable documents, including applications for patents and assignments thereof.

RECORDS AND DOCUMENTS

Except in the performance of your duties as an employee of Covance, you will not
at any time or in any manner make or cause to be made any copies, pictures,
duplicates, facsimiles, or other reproductions, recordings, abstracts, or
summaries of any reports, studies, memoranda, correspondence, manuals, customer
lists, software, records, formulae, plans or other written, printed, or
otherwise recorded material of any kind whatever belonging to or in the
possession of Covance or its subsidiaries or affiliates, which may be produced
or created by you or others, or which may come into your possession in the
course of your employment, or which relate in any manner to the then current or

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prospective business of Covance, its subsidiaries or its affiliates. You shall
have no right, title or interest in any such materials, and you agree that you
have not removed and will not remove such materials without the prior written
consent of Covance or its subsidiaries or affiliates, as applicable, and that
you will surrender all such material to Covance immediately upon your
termination or departure from Covance, or at any time prior thereto upon the
request of Covance.

INJUNCTIVE RELIEF

You agree that the remedies available to Covance at law for any breach of any of
your obligations under this Agreement may be inadequate, and you accordingly
agree and consent that temporary or permanent injunctive relief, and/or an order
of specific performance, may be granted in any proceeding which may be brought
to enforce any provision hereof, without the necessity of proof of actual
damage, in addition to any other remedies available to Covance at law.

OUTPLACEMENT

If there has been a Change-of-Control or if there has been no Change-of-Control
but you have been terminated without Cause, or if you choose not to continue
employment with Covance after the expiration of the Term, Covance shall provide
for you, at Covance's cost, executive outplacement support, from a firm of your
choice, for one-year following such termination.

SEPARATION AGREEMENT

If there has been a Change-of-Control or if there has been no Change-of-Control
but you have been terminated without Cause or you are entitled to severance
payments pursuant to the paragraph headed "SEVERANCE FOR TERMINATION OF
EMPLOYMENT FOLLOWING THE EXPIRATION OF THE TERM", the obligation of Covance to
make to you the Termination Payments or the Change-of-Control Payment, as
applicable, specified under this Agreement shall be subject to your execution
and delivery to Covance of a Separation Agreement in the form attached hereto as
Schedule C. Any sections of Schedule C that are bracketed are for illustrative
purposes only at this time and shall be finalized prior to execution of the
Separation Agreement based upon the applicable sections of this Amended and
Restated Agreement that relate to the exact circumstances of your termination.

APPROVAL OF PAYMENTS

The payment terms of this Amended and Restated Agreement are subject to and
conditional upon the approval of the Compensation and Organization Committee of
Covance Inc.

GENERAL

The provisions of employment relating to health benefits, vacation and
reimbursement for business expenses, professional dues, etc. remain unchanged
and will be administered in accordance with company policies, as they may be
amended, modified or supplemented from time to time. This Agreement shall be
governed by and construed in accordance with the laws of the State of New
Jersey.

The failure of either party at any time to require performance by the other
party of any provision hereof shall not affect in any way the full right to
require such performance at any time thereafter, nor shall a waiver by either
party of a breach of any provision hereof be taken or held to be a waiver of
future performance under the provision itself.

You hereby expressly agree that all of the covenants in this Agreement are
reasonable and necessary in order to protect Covance and its business. If any
provision or any part of any provision of this Agreement shall be invalid or
unenforceable under applicable law, such part shall be ineffective only to the
extent of such invalidity or unenforceability and shall not affect in any way
the validity or enforceability of the remaining provisions of this Agreement, or
the remaining parts of such provision.

                                       8
<PAGE>

This Agreement shall be binding on and inure to the benefit of the parties
hereto and their heirs, executors, legal representatives, successors and
assigns. Except in the event of a transfer to a successor corporation or other
entity or affiliate of Covance, neither party shall have the right to assign its
rights or delegate its obligations, or all or any portion of its rights or
interests under this Agreement without the prior written consent of the other
party hereto.

Any notice, request, demand, or other communication required or permitted by
this Agreement shall be deemed to be properly given if delivered by hand or when
mailed certified, registered or first class mail or overnight courier with
postage or shipping charge prepaid, addressed to Covance at 210 Carnegie Center,
Princeton, New Jersey 08540, Attention: CEO and to you at your address specified
above, and all such notices shall be deemed effective at the time of delivery or
at the time delivery is refused by the addressee upon participation. The
addresses for the purpose of this Paragraph may be changed only by giving
written notice of such change in the manner provided herein for giving notices.

The captions of the Paragraphs herein are inserted as a matter of convenience
only and in no way define, limit or describe the scope of this Agreement or any
provisions hereof.

This Agreement sets forth the entire agreement and understanding between the
parties hereto as to the subject matter hereof, and as such supersedes in its
entirety any existing agreement, whether oral or written, between you and
Covance including, but not limited to, the Former Agreement and the Letter
Agreement, except as expressly otherwise provided to the contrary under this
Agreement.

This Agreement may be amended only by a written instrument signed by both
parties hereto making specific reference to this Agreement and expressing the
plan or intention to modify it.

Please indicate your agreement with the terms and conditions of this Agreement
by signing one copy of this Agreement and returning it to my attention.

Very truly yours,

/s/ CHRISTOPHER A. KUEBLER
--------------------------------
Christopher A. Kuebler
President and CEO

Accepted as of the date first above specified:

By:  /s/ CHARLES C. HARWOOD
     ------------------------------
     Charles C. Harwood, Jr.

                                       9COVANCE INC.
                               210 CARNEGIE CENTER
                           Princeton, New Jersey 08540

                                                                 August 11, 2000

Jeffrey S. Hurwitz
c/o Covance Inc.
210 Carnegie Center
Princeton, New Jersey  08540

                              RESIGNATION AGREEMENT

Dear Jeffrey:

                  This Resignation Agreement will reflect our agreement
concerning your resignation as an officer and employee of Covance Inc. and any
and all predecessor companies, subsidiaries and affiliates wherever located
(individually and collectively, the "Company").

                  1.    RESIGNATION. By signing this Resignation Agreement, you
hereby agree to resign without further action by the parties hereto from all of
your positions as an officer and an employee of the Company and in any other
capacity in which you served the Company, effective as of May 22, 2000 (the
"Resignation Date").

                  2.    TERMINATION OF PRIOR AGREEMENTS AND UNDERSTANDINGS.
Except as expressly provided in this Resignation Agreement, as of the expiration
of the Revocation Period (as hereinafter defined), any written or oral
agreements or understandings between you and the Company are void and of no
further force and effect and this Resignation Agreement shall supersede all
prior agreements or understandings between you and the Company, including,
without limitation, the letter agreement setting forth the terms of your
employment, dated November 20, 1996, and the amendment thereto, dated November
20, 1998 (the "Employment Agreement").

                  3.    PAYMENTS AND BENEFITS IN CONNECTION WITH YOUR
RESIGNATION. Subject to the remedies for breach set forth in Section 7 and in
consideration of (a) your agreement to the covenants included in Sections 5, 6
and 9 hereof; and (b) the release of claims set forth in Section 10 hereof, the
Company agrees to concede that your resignation of employment for purposes of
your Employment Agreement shall be deemed an involuntary termination for reasons
other than for Cause (as such term is defined in the Employment Agreement) and,
as such, the Company shall be obligated to make the payments set forth below in
this Section 3 as though you were involuntarily terminated for reasons other
than for Cause.

                  (a)   You will continue to be paid under this Section 3(a) at
your current base salary of $223,860, less usual withholding taxes and other
customary deductions, for a period commencing on the Resignation Date and ending
May 22, 2002 (such period being the "Payment Period"). Such payments will be
made on the dates during the Payment Period that the Company makes its regular
payroll payments.

                  (b)   In addition to the sum specified in Section 3(a), on
March 15, 2001 the Company will pay you $123,123, less usual withholding taxes,
and on March 15, 2002 the Company will pay to you $123,123, less usual
withholding taxes, such amounts representing the annual incentives you might
otherwise have earned for the years 2000 and 2001.

                  (c)   In addition to the above sums, the Company will pay you
an amount equal to the value of your six (6) weeks accrued and unused vacation
time as of the Resignation Date, less usual withholding taxes. Such amount shall
be paid on such date as the Company makes its first regular payroll payment
after the execution of this Agreement.

<PAGE>

                  (d)   You shall be entitled to receive payments under or
withdraw the vested portion of your account under, as applicable, the Covance
Inc. Employee Stock Purchase Plan ("Employee Stock Purchase Plan"), the Covance
Inc. 401(k) Savings Plan (the "401(k) Plan"), the Covance Inc. Employee Stock
Ownership Plan (the "ESOP"), the Covance Inc. Supplemental Executive Retirement
Plan (the "SERP"), and any other savings, stock purchase, profit sharing,
retirement or 401(k) plans (collectively, the "Plans"), if any, in which you
participated during your employment with the Company or Corning Incorporated at
the times and in accordance with the provisions and restrictions of such Plans.

                  (e)   The amounts of any entitlements in the Plans shall be
determined as of the Resignation Date; PROVIDED, HOWEVER, that:

                  (i)   With respect to the Employee Stock Purchase Plan, it
         shall include stock purchased for your account at the end of the
         Offering Period (as defined in the Employee Stock Purchase Plan) which
         included the Resignation Date which is attributable to payroll
         deductions allocated to your account prior to the Resignation Date and
         with respect to the 401(k) Plan it shall include all employer matching
         contributions accruing through the Resignation Date and made at the end
         of the calendar quarter, which includes the Resignation Date. Any
         payroll deductions you make with respect to the Employee Stock Purchase
         Plan or the 401(k) Plan, however, will cease on the Resignation Date.

                  (ii)  For purposes of the SERP, you shall be credited with 14
         years of service thereunder.

                  (f)   With respect to medical and dental insurance after the
Resignation Date, it is hereby acknowledged that you are making the COBRA
election for continued medical and dental health insurance benefits for yourself
and eligible dependents, subject to the terms and conditions of the applicable
policies and all COBRA requirements, through the Payment Period. The Company
shall pay you an amount equal to the monthly premium for such coverage, less
usual withholding taxes and other customary withholdings, from the Resignation
Date through the Payment Period. Following the expiration of the statutory COBRA
period, the monthly medical and dental payment shall be equal to the last
premium in effect during such statutory period. Such payments will be made to
you in equal installments on the dates during the Payment Period that the
Company makes its regular payroll payments. Current Company-paid life insurance
coverage will continue, at the Company's expense, through the Payment Period.
For a period of 30 days following the expiration of the Payment Period, you
shall have the right, at your expense, and subject to customary withholdings, to
convert the life insurance coverage to an individual policy, without evidence of
insurability, subject to the terms and restrictions under the life insurance
policy. The Company also will reimburse you for an amount not to exceed $10,000
(subject to usual withholdings) during the Payment Period for the payment of
disability insurance premiums upon receipt of reasonably satisfactory
documentation.

                  Notwithstanding anything in this Section 3(f) to the contrary,
you agree that if you obtain or are provided with medical, dental, life and/or
disability insurance from a new employment position which provides equal or
superior coverage and benefits in the aggregate to that provided by the Company
under the respective benefit plans of the Company or through reimbursement by
the Company and at an equivalent or lesser expense (both deductible and direct)
to you, then you shall promptly notify the Company which of such insurance
benefits is then being provided to you and the Company shall cease providing
such coverage or discontinue paying the premiums for such insurance, as
applicable.

                  (g)   The Company will provide you outplacement services for
the period beginning May 22, 2000 and ending May 22, 2001, as follows: As soon
as practicable following the execution of this Agreement, the Company shall pay
$25,000 directly to Executive Transformetrics. If, by November 22, 2000, you
shall not have secured full-time employment, the Company shall make a second and
final payment of $10,000 to Executive Transformetrics. Except as provided in the
immediately preceding sentence, the Company shall have no further obligation
with respect to outplacement services provided to you.

                  (h)   You shall have, as of the Resignation Date, until the
third anniversary of the Resignation Date to exercise all incentive and
non-qualified stock options granted to Employee under the Employee Equity
Participation Plan and the Conversion Equity Participation Plan ("CEP"), as
applicable, as more fully specified in the attached "Optionee Statement" except
for 9,933 stock options granted under that certain Non-Qualified Stock Option
Agreement between the Company and you dated February 18, 1998, 11,533 stock
options granted under that certain Non-Qualified Stock Option Agreement between
the Company and you dated February 25, 1999 and 19,000 stock options granted

<PAGE>

under that certain Non-Qualified Stock Option Agreement dated as of January 1,
2000 (the "Forfeited Options"). The Forfeited Options shall terminate and be of
no further force and effect on the Resignation Date. Notwithstanding anything
contained in that certain Restricted Stock Agreement dated February 18, 1998 to
the contrary, the Company shall deliver to you on December 31, 2000 a stock
certificate representing 8,255 shares of Covance Inc. common stock endorsed in
your name. In the event you have not arranged to reimburse the Company for taxes
associated with such distribution, the number of shares of common stock
represented by such certificate shall be reduced by the amount necessary to pay
all applicable taxes arising from such distribution.

                  (i)   After receipt of reasonably satisfying documentation of
the type and amounts of services, the Company shall directly pay up to $6,000
for the calendar year ending 2000 and $6,000 for the calendar year ending 2001
for actual professional fees for tax and/or financial counseling services
provided to Employee.

                  (j)   The Company will continue to provide you with a car
allowance of $1,070 per month (less usual tax withholdings) through the Payment
Period and you shall remain responsible for all expenses and liabilities
incident to the ownership and use of your car before and after such date.

                  (k)   The Company shall promptly reimburse you for all
reasonable business expenses incurred by you on or prior to the Resignation Date
in accordance with its existing expense reimbursement policies.

                  (l)   In the event that a Change of Control (as defined in the
Employment Agreement) occurs on or before the expiration of the Payment Period,
then all remaining cash payments under Section 3 shall automatically be
accelerated and paid to you in a lump sum promptly after such Change of Control.

                  In the event the Change in Control occurs before December 31,
2000, then the restricted stock referred to in Section 3(h) shall become free
from restriction on the date of the Change in Control and the Company shall
deliver to you a stock certificate for such unrestricted shares promptly after
such Change in Control.

                  In the event you are involved in any dispute about your rights
or obligations under this Resignation Agreement arising on or after a Change of
Control, the Company shall pay all legal costs, expenses and fees incurred by
you in connection with such dispute promptly upon receipt of any invoice
relating thereto.

                  4.    NO OTHER SEVERANCE, PAYMENTS OR BENEFITS. Except as
otherwise expressly provided herein, you hereby acknowledge and agree that you
are not entitled to any other compensation or benefits from the Company in
connection with your resignation of employment or otherwise and that, except as
expressly set forth herein, you are not entitled to any severance or similar
benefits under any plan, program, policy or arrangement, whether formal or
informal, written or unwritten, of the Company.

                  5.    RESTRICTIVE COVENANTS. In partial consideration of the
resignation payments and benefits to be paid and provided to you in accordance
with Section 3 above, you hereby agree to abide by the covenants included in
this Section 5, which you acknowledge and agree are reasonable in scope and
duration. The activities described in this Section 5 shall be prohibited
regardless of whether undertaken by you in an individual or representative
capacity, and regardless of whether performed for your own account or for the
account of any other individual, partnership, firm, corporation, or other
business organization (other than the Company).

         (a)      NON-COMPETITION

                  (i)   Unless authorized by the Company's Board of Directors in
         writing, you shall not, for one year after the Resignation Date (the
         "Post Employment Term"), become employed by, become a director,
         officer, shareholder or partner of, or otherwise enter into, conduct,
         or advise any business, whether directly or indirectly, which offers
         services or products in the United States and any other geographical
         regions where the Company, or its subsidiaries or its affiliates, is
         then offering its services or products in competition with services or
         products sold by the Company, or its subsidiaries or its affiliates at
         any time during the Post Employment Term in the United States or such
         region, including, without limitation, the conduct of contract
         pre-clinical toxicology laboratory services, contract biopharmaceutical
         clinical laboratory services, contract bioprocessing or manufacturing
         services, contract drug packaging services, Phase I, II, III or IV

<PAGE>

         clinical studies or outcomes or disease management studies
         (collectively, the "Covance Services"); provided that you shall not be
         bound by the restrictions contained in this Section 5(a) unless the
         Company has made all payments to you which are due and owing to you
         under this Resignation Agreement.

                  Nothing herein shall restrict you in your employment in any
         capacity by a corporation or entity engaged substantially in the
         manufacture or sale of pharmaceuticals, or any other business which
         does not offer Covance Services. Ownership of not more than 1% of the
         issued and outstanding shares of any class of securities of a
         corporation, the securities of which are traded on a national
         securities exchange or in the over-the-counter market, shall not cause
         you to be deemed a shareholder under this provision.

                  (ii)  During the Post Employment Term, you shall not, directly
         or indirectly, solicit, divert or accept any business from any customer
         of the Company to the detriment of the Company or seek to cause any
         such customers to refrain from doing business with or patronizing the
         Company.

                  (iii) During the Post Employment Term, you shall not, directly
         or indirectly, solicit or induce for employment any employee of the
         Company or otherwise encourage any employee of the Company to leave the
         Company. For purposes of this Resignation Agreement, advertisements in
         trade magazines, use of executive search firms and other conventional
         means of obtaining employees shall not be construed as solicitation,
         inducements or encouragement unless the party utilizing such
         conventional means specifically directs the efforts at employee(s) with
         whom the party may not have contact pursuant to the terms of this
         Resignation Agreement.

                  (iv)  For purposes of this Resignation Agreement, the term
         "directly or indirectly" shall be construed in its broadest sense and
         shall include the activities of the members of your immediate family or
         any partnership, or as otherwise specified above, and the term
         "customer" shall mean any person or entity to which the Company has
         sold services during the one-year period prior to the Resignation Date
         or any persons or entities targeted by the Company or contacted for the
         purpose of selling such services during such one-year period which you
         knew about or reasonably should have known about.

         (b)      CONFIDENTIALITY

                  The Company possesses and will continue to possess trade
secrets or other information which has been created, discovered, developed by or
otherwise come known to the Company, or in which property rights have been
assigned or otherwise conveyed to the Company, which information has commercial
value with respect to the business and operations of the Company, including, but
not limited to, information regarding sales, costs, customers, employees,
products, services, apparatus, equipment, processes, formulae, marketing, or the
organization, business or finances of the Company, or any information you have
reason to know the Company would like to treat as confidential for any purpose,
such as maintaining a competitive advantage or avoiding undesirable publicity,
whether or not developed by you ("Confidential Information"). Unless previously
authorized in writing or instructed in writing by the Company, you will not,
directly or indirectly, use for your own benefit or purposes, or disclose to, or
use for the benefit or purposes of, anyone other than the Company, any
Confidential Information, unless and until, and then only to the extent that,
such Confidential Information has (a) been or becomes published, or is or
becomes generally known in the trade through no fault of you, or (b) such
information is made known and available to you by a third party, who, by such
disclosure to you does not breach any duty or obligation to the Company.

                  In the event you become legally compelled to disclose any of
the Confidential Information, you will provide the Company with prompt notice so
that the Company may seek a protective order or other appropriate remedy and/or
waive compliance with the provisions of this Resignation Agreement. If, in the
absence of a protective order or the receipt of a waiver hereunder, you are
nonetheless legally required to disclose Confidential Information to any
tribunal or else stand liable for contempt or suffer other censure or penalty,
you may disclose such Confidential Information to such tribunal without
liability hereunder.

<PAGE>

                  On the Resignation Date, you will deliver to the Company all
written embodiments of the Confidential Information, including all notes,
drawings, records, reports, pertaining to work done by you during your
employment with the Company and all other matters of secret or confidential
nature relating to the Company's business.

         (c)      OWNERSHIP OF KNOW-HOW, INVENTIONS AND OTHER INTELLECTUAL
PROPERTY

                  All the know-how, innovations, inventions, discoveries,
improvements, procedures, programs, formulae and specifications which have been
or may be either, directly or indirectly, developed, conceived or made by you in
connection with your employment with the Company, whether or not in concert with
other employees or shown or delivered to the Company or any of its subsidiaries
or its affiliates, and whether or not they are eligible for patent, copyright,
trademark, trade secret or other legal protection, shall be the exclusive
property of the Company and you shall, at the Company's request and expense,
promptly execute any and all documents or instruments which may be necessary to
evidence such ownership.

                  You will communicate to the Company promptly and fully all
improvements and inventions you made or conceived (either solely or jointly with
others) during the period of your employment with the Company and conceived by
you during the Post Employment Term if based on or related to your employment at
the Company.

         (d)      PATENTS

                  You will, during and after Post Employment Term, at the
Company's request and expense but without additional compensation, assist the
Company and its nominees in every proper way to obtain and to vest in the
Company or its nominees, title to patents on such improvements and inventions in
all countries, by executing all necessary or desirable documents, including
applications for patents and assignments thereof.

         (e)      RECORDS AND DOCUMENTS

                  Except in the performance of your duties as an employee of the
Company, you agree that you have not at any time or in any manner made or caused
to be made any copies, pictures, duplicates, facsimiles, or other reproductions,
recordings, abstracts, or summaries of any reports, studies, memoranda,
correspondence, manuals, customer lists, software, records, formulae, plans, or
other written, printed, or otherwise recorded material of any kind whatever
belonging to or in the possession of the Company, which may have been produced
or created by you or others, or which may have come into your possession in the
course of your employment, or which relate in any manner to the then current or
prospective business of the Company. You agree that you have no right, title or
interest in any such materials, and you agree that you have not removed and will
not remove such materials without the prior written consent of the Company, as
applicable, and that you will surrender all such material to the Company on the
Resignation Date. Nothing in this Resignation Agreement or the Employment
Agreement shall prohibit you from retaining copies of any precedences, standard
forms, legal practice manuals or policies, plans or any information about the
Company which is publicly available.

                  6.    MUTUAL CONFIDENTIALITY AGREEMENT. Each of the parties
hereto hereby agrees that the terms of this Resignation Agreement and all
communications between either party and its respective counsel regarding the
same and any and all events, allegations, actions and circumstances related to
your resignation from the Company shall be kept strictly confidential and shall
not be disclosed to anyone except (i) as reasonably necessary to enforce the
terms of this Resignation Agreement, (ii) to the parties' legal, financial,
benefits, tax advisors, (iii) your spouse, (iv) your executive assistant (who
acknowledges that any information received by her is confidential) and/or (v)
pursuant to compulsory legal process or court order. Notwithstanding the
foregoing, you may inform any prospective employer or contracting party that you
are restricted from engaging in conduct or taking action prohibited or
restricted by Sections 5, 6 and 9 of this Resignation Agreement.

                  7.    REMEDIES. (a) BREACH BY YOU. You hereby acknowledge and
agree that damages for a breach or threatened breach of any of the covenants set
forth in Section 5, 6, or 9 will be difficult to determine and will not afford a
full and adequate remedy, and therefore you agree that the Company, in addition
to seeking actual damages in connection therewith, may seek specific enforcement
of any such covenant in any court of competent jurisdiction, including, without
limitation, by the issuance of a temporary or permanent injunction. In addition,
if you breach in any respect the provisions of Section 5, 6, or 9 then, in
addition to any other remedies the Company may have at law or in equity, you
shall immediately forfeit any and all rights to future payments under Section 3
above.

<PAGE>

                  Notwithstanding anything in this Section 7(a) to the contrary,
if you violate any of the covenants in Sections 5, 6, or 9 hereof, then the
Company shall first promptly notify you of such violation in accordance with the
requirements of Section 15 of this Resignation Agreement before terminating any
of its obligations to you under Section 3, and, for those violations that are
susceptible to cure, you shall remedy your non-compliant actions or inactions,
promptly but no later than 10 days from the date of such notice (the "Cure
Period"). In the event you do not effectuate such cure during the Cure Period,
then the Company shall be immediately thereafter permitted to enforce all of its
rights and remedies, including, without limitation, the termination of its
obligations under Section 3.

                  (b)   BREACH BY COMPANY. In the event the Company does not
honor its obligations for payments or distributions under this Resignation
Agreement when such payments or distributions are due and owing or otherwise
violates any of its obligations to you under this Resignation Agreement, you
shall promptly notify the Company, in accordance with the requirements specified
in Section 15 of this Resignation Agreement, of such breach and if the Company
then fails to make such payment or payments or otherwise fails to cure such
non-compliant behavior (to the extent such violations are susceptible to cure)
within ten business days of such notice, then you shall be released from your
obligations under this Resignation Agreement. Such release shall be in addition
to any other rights or remedies permitted to you in law or equity that arise
from the Company's breach of its obligations under this Resignation Agreement.

                  8.    LITIGATION. (a) You agree to make yourself reasonably
available for consultation with the Company and its counsel, at such times and
locations as shall be reasonably agreed upon by you and the Company, and to
cooperate fully with the Company in the defense of any lawsuits, actions, and
judicial or administrative proceedings now existing or hereafter arising
relating to all matters in which you had any material involvement or for which
you rendered material services of the Company. The Company agrees to reasonably
compensate you for such consultant services at the rate of $250 per hour.

                  (b)   You agree to notify the Company as soon as is
practicable of your receipt of any request (whether voluntary or compulsory in
the form of a subpoena, court order, deposition notice or otherwise) requiring
you to appear at any trial, hearing or deposition to give testimony or to
produce documents or records in your possession, custody or control relating to
any matter involving the Company or any duties or services you performed for the
Company and to give the Company, to the extent possible, a reasonable
opportunity to dispute such order or subpoena before making such disclosure.

                  9.    UNFAVORABLE COMMENTS; STATEMENTS REGARDING YOUR
RESIGNATION. (a) You agree to refrain from making now or at any time in the
future any false or defamatory comment, statement or other communication
concerning the Company, its services or any current or former directors,
officers or employees of the Company to any third party, including, without
limitation, the press, any employee of the Company and any individual or entity
with whom you or the Company has a current or prospective business relationship.

                  (b)   The Company agrees to refrain and to cause its officers,
directors and employees to refrain from making now or at any time in the future
any false or defamatory comment, statement or other communication concerning you
or your employment relationship with the Company to any third party, including,
without limitation, the press, any employee of the Company and any individual or
entity with whom you or the Company has a current or prospective business
relationship.

                  (c)   You and the Company hereby agree that you have resigned
from your employment with the Company pursuant to a mutually acceptable
resignation agreement, the terms of which are confidential (except as provided
in Section 6).

<PAGE>

                  (d)   All inquiries from potential future employers regarding
your employment with the Company will be directed to Human Resources, who will
respond solely by (i) confirming the dates that you were employed by the
Company, (ii) verifying your position, (iii) confirming that you resigned
pursuant to a mutually acceptable resignation agreement and (iv) stating that it
is Company policy not to provide additional information regarding its former
employees. Compensation information will be released only upon your written
authorization to do so.

                  Notwithstanding anything in this Section 9 to the contrary,
you shall be permitted to provide to any third party the letter of
recommendation from the Company in the form of Exhibit A hereto (the "Letter of
Recommendation") and you shall be permitted to refer any reference inquiries to
the Chief Executive Officer of the Company who shall provide a verbal reference
on your behalf that is no less favorable to you in any respect than the Letter
of Recommendation. Upon your request, the Chief Executive Officer shall provide
you or your designee as requested by you the Letter of Recommendation as often
as you may reasonably request. To the extent that any prospective employer wants
to speak to any individual who is or was a member of the Company's Board of
Directors on the Resignation Date about you, such Board member shall direct such
prospective employer to the Chief Executive Officer of the Company.
Notwithstanding the foregoing, in the event such Board member responds to any
inquiry concerning you, any comments by such Board member shall be no less
favorable in any respect than the Letter of Recommendation.

                  10.   MUTUAL RELEASE. (a) For purposes of this Mutual Release,
"Employee Parties" means you, your estate, your beneficiaries, your heirs and
your assigns and the estate, beneficiaries, heirs and assigns of each of the
foregoing. "Company Parties" means the Company, including any affiliate, parent,
subsidiary, predecessor or successor of the Company and each of its present,
former and future directors, officers, employees, agents, attorneys, heirs and
assigns. The Employee Parties and the Company Parties together shall hereinafter
be referred to as the "Released Parties."

                  (b)   In consideration of the mutual consideration set forth
herein, the receipt and adequacy of which are herein acknowledged, and intending
to be legally bound hereby, the Company Parties, on the one hand, and the
Employee Parties, on the other hand, hereto do hereby release and discharge each
other from any and all claims, actions, causes of action, suits, costs,
controversies, judgments, decrees, verdicts, damages, liabilities, attorneys'
fees, covenants, contracts, and agreements that any of the Employee Parties or
Company Parties ever had, now has or can, shall or may have for, upon, by reason
of, relating to, or in connection with any matter, cause or thing whatsoever,
from the beginning of the world to the Resignation Date, with respect to each
other (the "Released Claims"), including, but not limited to, any claims arising
under Title VII of the Civil Rights Act of 1964, the Rehabilitation Act of 1973,
the Americans with Disabilities Act of 1990, the Civil Rights Act of 1866, the
Civil Rights Act of 1991, the Employee Retirement Income Security Act of 1974,
the Family Medical Leave Act of 1993 or any other federal or state or local law,
whether such claim arises under statute, common law or in equity, and whether or
not any of the Released Parties are presently aware of the existence of such
claim, damage, action or cause of action, suit or demand. The Company Parties,
on the one hand, and the Employee Parties, on the other, also do forever
release, discharge and waive any right they may have to recover in any
proceeding brought by any federal, state or local agency against any other party
hereto to enforce any laws. Each of the parties hereto agrees that the value
received as described in this Resignation Agreement shall be in full
satisfaction of any and all claims, actions or causes of action for payment or
other benefits of any kind that any party or Released Parties hereto may have
against another party hereto and or any corresponding Released Parties.

                  (c)   In further recognition of the consideration cited above,
the Employee Parties hereby release and forever discharge each of the Company
Parties from any and all claims, actions and causes of action that the Employee
Parties may have as of the date you sign and deliver to the Company this
Resignation Agreement arising under the federal Age Discrimination in Employment
Act of 1967, as amended, and the applicable rules and regulations promulgated
thereunder ("ADEA") which may be based in whole or in part on age
discrimination.

                  (d)   The releases contained in this Section 10 do not release
the Company Parties from any obligation to indemnify you as an officer or
employee under the Company's Articles of Incorporation (or similar organization
document), By-laws or under the law of any jurisdiction where the Company or any
of the Company Parties is organized. In addition, the releases contained in this
Section 10 do not release you or the Company from the respective rights and
obligations set forth in this Resignation Agreement.

                  11.   ACKNOWLEDGMENT. By signing this Resignation Agreement,
you hereby acknowledge and confirm the following:

<PAGE>

                  (a)   You were advised by the Company in connection with your
resignation to consult with an attorney of your choice prior to signing this
Resignation Agreement and to have such attorney explain to you the terms of this
Resignation Agreement including, without limitation, the terms relating to your
release of claims arising under ADEA.

                  (b)   You were given not less than 21 days to consider the
terms of this Resignation Agreement and to consult with an attorney of your
choosing with respect thereto, and that for a period of seven days following
your acceptance hereof, you have the option to revoke such acceptance in
accordance with the terms set forth below.

                  (c)   You knowingly and voluntarily accept the terms of this
mutual release.

                  12.   REVOCATION. You shall have the right to revoke this
Resignation Agreement during the seven-day period (the "Revocation Period")
commencing immediately following the date you sign and deliver this Resignation
Agreement to the Company. The Revocation Period shall expire at 5:00 p.m.
Eastern Standard Time on the last day of the Revocation Period; provided,
however, that if such seventh day is not a business day, the Revocation Period
shall extend to 5:00 p.m. on the next succeeding business day. In the event of
any such revocation by you, all obligations of the Company under this
Resignation Agreement shall terminate and be of no further force and effect as
of the date of such revocation. No such revocation by you shall be effective
unless it is in writing and signed by you and received by the Company prior to
the expiration of the Revocation Period.

                  13.   ACCEPTANCE. You may indicate your acceptance of this
Resignation Agreement by signing and dating both copies of this Resignation
Agreement and delivering one such copy to the Chief Executive Officer of the
Company If you revoke your acceptance of this Resignation Agreement during the
Revocation Period, this Resignation Agreement shall immediately lapse and become
void.

                  14.   GOVERNING LAW. This Resignation Agreement shall be
governed by, and construed in accordance with, the laws of the State of New
Jersey applicable to contracts to be performed exclusively therein without
regard to the choice of law provisions thereof.

                  15.   NOTICES. All notices or communications hereunder shall
be in writing, addressed as follows:

                  To the Company:

                           Covance Inc.
                           210 Carnegie Center
                           Princeton, New Jersey  08540-6233
                           Telecopier No.:  (609) 452-4430
                           Attention:  Chief Executive Officer

                  With a copy to:

                           Shearman & Sterling
                           599 Lexington Avenue
                           New York, New York  10022
                           Telecopier No.:  (212) 848-7179
                           Attention:  John J. Cannon, III, Esq.

                  To you:

                           Jeffrey S. Hurwitz
                           [address intentionally left blank]
                           Telecopier No.:  [intentionally left blank]

<PAGE>

                  16.   TAX CONSIDERATIONS. Without duplication to any other
provision of this Resignation Agreement, any payments made to you under this
Resignation Agreement shall be reduced by the full amount legally required to be
withheld for federal, state or local income or other payroll tax purposes by the
Company.

                  17.   SUCCESSORS AND ASSIGNS. The Company's obligations
hereunder shall be binding on the Company's successors and assigns, whether by
merger, operation of law, contract or otherwise.

                  18.   ALTERNATIVE PAYEE. In the event that you die before any
of the money owing to you under this Resignation Agreement is paid in full, then
the Company shall make such remaining payments to your spouse, or, if you have
no spouse at the time of your demise, to your estate. Upon the Company's written
request, your spouse or estate, as applicable, shall execute and deliver to the
Company a written acknowledgment that such payments are subject to the terms
hereof. Such acknowledgment shall be provided within 15 days of the date
requested by the Company and the Company shall be entitled to suspend payments
hereunder after the passage of such 15 days until it receives such
acknowledgment.

                  19.   COUNTERPARTS. This Resignation Agreement may be executed
in two or more counterparts, each of which shall be deemed to be an original but
all of which together will constitute one and the same instrument.Your signature
on the line below constitutes your agreement with each provision contained
herein.

                                        COVANCE INC.

                                        By: /s/ CHRISTOPHER A. KUEBLER
                                            -------------------------------
                                            Christopher A. Kuebler
                                            Title:  President

ACKNOWLEDGED AND AGREED:

/s/ JEFFREY S. HURWITZ
-------------------------------
Jeffrey S. Hurwitz

Date:
      -------------------------

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