Document:

EX-4.2

 Exhibit 4.2 

FIRST AMENDMENT 
 OF

 OPTUM PARTNER SERVICES 

EXECUTIVE SAVINGS PLAN 

WHEREAS, Optum Medical Services, P.C. (“Optum”), has established and maintains a nonqualified, deferred compensation plan
(the “Plan”) for the benefit of a select group of management or highly compensated employees of Optum and certain of its affiliates, most recently amended and restated, effective as of January 1, 2019; and 

WHEREAS, Optum wishes to amend the Plan, effective as of June 23, 2019, for the purpose of recognizing Riverside Pediatric Group,
P.C. as a new Employer. 
 NOW, THEREFORE, BE IT RESOLVED, that the Plan is hereby amended in the following respects,
effective as of June 23, 2019: 
 1.    ADDITION OF PARTICIPATING EMPLOYER. Schedule I to the Plan is amended, in the
form attached hereto, to add Riverside Pediatric Group, P.C. to the list of Employers set forth therein. 
 2.    SAVINGS
CLAUSE. Save and except as hereinabove expressly amended, the Plan Statement shall continue in full force and effect. 
 IN WITNESS
WHEREOF, Optum has caused these presents to be executed, as of the date and year written below and effective as of the date indicated in each of the foregoing amendment clauses. 

Executed June 20, 2019. 
  

	
	OPTUM MEDICAL SERVICES, P.C.
	
	 /s/ Ronald Shumacher, M.D.

	Ronald Shumacher, M.D., President

 SCHEDULE I 

EMPLOYERS PARTICIPATING 

IN THE 
 OPTUM PARTNER
SERVICES EXECUTIVE SAVINGS PLAN 
 (Effective as of June 23, 2019) 

Optum Medical Services, P.C. (Plan Sponsor) 
 Centers for Family
Medicine, GP 
 Greater Phoenix Collaborative Care, P.C. 

Inspiris Medical Services of New Jersey, P.C. 
 Inspiris of
Michigan Medical Services, P.C. 
 Inspiris of New York Medical Services, P.C. 

Inspiris of Pennsylvania Medical Services, P.C. 
 Inspiris of
Texas Physicians Group 
 Memorial Healthcare IPA, GP 
 Monarch
HealthCare, A Medical Group, Inc. 
 Optum Clinic, P.A. 
 Optum
Medical Services of Colorado, P.C. 
 Prohealth Physicians, P.C. 

Riverside Pediatric Group, P.C. 
 Robert B. McBeath, M.D., P.C.

 Robert B. McBeath, M.D. II, P.C. 
 Robert B. McBeath, M.D.
III, P.C. 
 TeamMD Physicians of Texas, Inc. 
 TeamMD
Physicians, P.C. (formerly known as Mobile Medical Professionals, Inc.) 
 WellMed Medical Group, P.A. 

WellMed Networks Florida, Inc. 
 WellMed Networks, Inc. 

WND Medical, PLLC dba WellMed Family Care 
 XLHome, P.C 

XLHome of Michigan, P.C. 
 XLHome Northeast, P.C. 

XLHome Oklahoma, Inc. 

  
 - 2 -EX-4.3

 Exhibit 4.3 

SECOND AMENDMENT 
 OF

 OPTUM PARTNER SERVICES 

EXECUTIVE SAVINGS PLAN 

WHEREAS, Optum Medical Services, P.C. (“Optum”), has established and maintains the Optum Partner Services Executive Savings
Plan (the “Plan”) for the benefit of a select group of management or highly compensated employees of Optum and certain of its affiliates, most recently amended and restated, effective as of January 1, 2019; and 

WHEREAS, Optum wishes to amend the Plan, effective as of the dates set forth below, for the purpose of recognizing certain new
participating related Employers. 
 NOW, THEREFORE, BE IT RESOLVED, that the Plan is hereby amended in the following respects,
effective as of the dates set forth below: 
 1.    ADDITION OF 4C MEDICAL GROUP, PLC. Schedule I to the Plan is amended,
in the form attached hereto as Exhibit A, to add 4C Medical Group, PLC to the list of Employers set forth therein, effective as of September 15, 2019. 

2.    ADDITION OF ROBERT B. McBEATH, M.D. II, P.C. Schedule I to the Plan is further amended, in the form attached hereto as
Exhibit B, to add Robert B. McBeath, M.D. II, P.C. to the list of Employers set forth therein, effective as of October 1, 2019. 

3.    SAVINGS CLAUSE. Save and except as hereinabove expressly amended, the Plan Statement shall continue in full force and
effect. 
 IN WITNESS WHEREOF, Optum has caused these presents to be executed, as of the date and year written below and effective as
of the date indicated in each of the foregoing amendment clauses. 
 Executed September 13, 2019. 

 

	
	OPTUM MEDICAL SERVICES, P.C.
	
	 /s/ Ronald Shumacher, M.D.

	Ronald Shumacher, M.D., President

 Exhibit A 

SCHEDULE I 
 EMPLOYERS
PARTICIPATING 
 IN THE 

OPTUM PARTNER SERVICES EXECUTIVE SAVINGS PLAN 

(Effective as of September 15, 2019) 

Optum Medical Services, P.C. (Plan Sponsor) 
 4C Medical Group,
PLC 
 Centers for Family Medicine, GP 
 Greater Phoenix
Collaborative Care, P.C. 
 Inspiris Medical Services of New Jersey, P.C. 

Inspiris of Michigan Medical Services, P.C. 
 Inspiris of New York
Medical Services, P.C. 
 Inspiris of Texas Physicians Group 

Medical Clinic of North Texas, PLLC 
 Memorial Healthcare IPA, GP

 Monarch HealthCare, A Medical Group, Inc. 
 Optum Clinic,
P.A. 
 Optum Medical Services of Colorado, P.C. 
 ProHealth
Physicians, P.C. 
 Riverside Pediatric Group, P.C. 
 Robert B.
McBeath, M.D., P.C. 
 Robert B. McBeath, M.D. III, P.C. 

TeamMD Physicians of Texas, Inc. 
 TeamMD Physicians, P.C.
(formerly known as Mobile Medical Professionals, Inc.) 
 WellMed Medical Group, P.A. 

WellMed Networks Florida, Inc. 
 WellMed Networks, Inc. 

WND Medical, PLLC dba WellMed Family Care 
 XLHome, P.C 

XLHome of Michigan, P.C. 
 XLHome Northeast, P.C. 

XLHome Oklahoma, Inc. 

  
 - 2 - 

 Exhibit B 

SCHEDULE I 
 EMPLOYERS
PARTICIPATING 
 IN THE 

OPTUM PARTNER SERVICES EXECUTIVE SAVINGS PLAN 

(Effective as of October 1, 2019) 

Optum Medical Services, P.C. (Plan Sponsor) 
 4C Medical Group,
PLC 
 Centers for Family Medicine, GP 
 Greater Phoenix
Collaborative Care, P.C. 
 Inspiris Medical Services of New Jersey, P.C. 

Inspiris of Michigan Medical Services, P.C. 
 Inspiris of New York
Medical Services, P.C. 
 Inspiris of Texas Physicians Group 

Medical Clinic of North Texas, PLLC 
 Memorial Healthcare IPA, GP

 Monarch HealthCare, A Medical Group, Inc. 
 Optum Clinic,
P.A. 
 Optum Medical Services of Colorado, P.C. 
 ProHealth
Physicians, P.C. 
 Riverside Pediatric Group, P.C. 
 Robert B.
McBeath, M.D., P.C. 
 Robert B. McBeath, M.D. II, P.C. 
 Robert
B. McBeath, M.D. III, P.C. 
 TeamMD Physicians of Texas, Inc. 

TeamMD Physicians, P.C. (formerly known as Mobile Medical Professionals, Inc.) 

WellMed Medical Group, P.A. 
 WellMed Networks Florida, Inc. 

WellMed Networks, Inc. 
 WND Medical, PLLC dba WellMed Family Care

 XLHome, P.C 
 XLHome of Michigan, P.C. 

XLHome Northeast, P.C. 
 XLHome Oklahoma, Inc. 

  
 - 3 -EX-4.2

 Exhibit 4.2 

Execution Version 
  

 
 THERMO FISHER SCIENTIFIC INC., 

as Issuer 
 AND 

THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., 

as Trustee 
 EIGHTEENTH
SUPPLEMENTAL INDENTURE 
 Dated as of September 30, 2019 

0.125% Senior Notes due 2025 

0.500% Senior Notes due 2028 

0.875% Senior Notes due 2031 

1.500% Senior Notes due 2039 

1.875% Senior Notes due 2049 
  

 

 THIS EIGHTEENTH SUPPLEMENTAL INDENTURE (this “Supplemental Indenture”) is
dated as of September 30, 2019 between THERMO FISHER SCIENTIFIC INC., a Delaware corporation (the “Company”), and THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., a national banking association, as trustee (the
“Trustee”). 
 RECITALS 

WHEREAS, the Company and the Trustee executed and delivered an Indenture, dated as of November 20, 2009 (the “Base
Indenture” and, as supplemented by this Supplemental Indenture, the “Indenture”), to provide for the issuance by the Company from time to time of unsubordinated debt securities evidencing its unsecured indebtedness. 

WHEREAS, the Company has authorized the issuance of €800,000,000 aggregate principal amount of the Company’s 0.125% Senior Notes due
2025 (the “2025 Notes”), €800,000,000 aggregate principal amount of the Company’s 0.500% Senior Notes due 2028 (the “2028 Notes”), €900,000,000 aggregate principal amount of the Company’s 0.875%
Senior Notes due 2031 (the “2031 Notes”), €900,000,000 aggregate principal amount of the Company’s 1.500% Senior Notes due 2039 (the “2039 Notes”) and €1,000,000,000 aggregate principal amount of the
Company’s 1.875% Senior Notes due 2049 (the “2049 Notes” and, together with the 2025 Notes, the 2028 Notes, the 2031 Notes and the 2039 Notes, the “Notes”). 

WHEREAS, the entry into this Supplemental Indenture by the parties hereto is in all respects authorized by the provisions of the Base
Indenture. 
 WHEREAS, the Company desires to enter into this Supplemental Indenture pursuant to Section 9.01 of the Base Indenture to
establish the terms of the Notes in accordance with Section 2.01 of the Base Indenture and to establish the form of the Notes in accordance with Sections 2.01(a)(10) and 2.02 of the Base Indenture. 

WHEREAS, all things necessary to make this Supplemental Indenture a valid and legally binding agreement according to its terms have been done.

 NOW, THEREFORE, for and in consideration of the foregoing premises, the Company and the Trustee, mutually covenant and agree for the
equal and proportionate benefit of the respective Holders from time to time of the Notes as follows: 
 ARTICLE I 

Section 1.1    Defined Terms. 

(1)    Capitalized terms used but not defined in this Supplemental Indenture shall have the meanings ascribed thereto in
the Base Indenture. 
 (2)    A term defined anywhere in this Supplemental Indenture has the same meaning throughout.

  
 1 

 (3)    The singular includes the plural and vice versa. 

(4)    Headings are for convenience of reference only and do not affect the interpretation. 

(5)    As used herein, the following defined terms shall have the following meanings with respect to the Notes and this
Supplemental Indenture only: 
 “Additional Amounts” has the meaning set forth in Section 1.4(2). 

“Below Investment Grade Rating Event” means, with respect to a series of Notes, such Notes are downgraded below an Investment
Grade Rating by any two of the Rating Agencies on any date during the period (the “Trigger Period”) commencing 60 days prior to the first public announcement by the Company of the occurrence of a Change of Control (or pending Change
of Control) and ending 60 days following consummation of such Change of Control (which Trigger Period shall be extended so long as the rating of such Notes is under publicly announced consideration for possible downgrade by at least two of such
Rating Agencies on such 60th day, such extension to last with respect to each such Rating Agency until the date on which such Rating Agency considering such possible downgrade either (x) rates such Notes below an Investment Grade Rating or
(y) publicly announces that it is no longer considering such Notes for possible downgrade, provided that no such extension will occur if on such 60th day such Notes have an Investment Grade Rating from at least two of such Rating
Agencies in question and are not subject to review for possible downgrade by such Rating Agencies). 
 “Business Day” means
any day, other than a Saturday or Sunday, (1) which is not a day on which banking institutions in The City of New York or London are authorized or required by law, regulation or executive order to close and (2) on which the Trans-European
Automated Real-Time Gross Settlement Express Transfer system (the TARGET2 system), or any successor thereto, is open. 
 “Change of
Control” means the occurrence of any of the following: (1) the direct or indirect sale, transfer, conveyance or other disposition (other than by way of merger or consolidation), in one or a series of related transactions, of all or
substantially all of the properties or assets of the Company and its subsidiaries taken as a whole to any “person” (as that term is used in Section 13(d)(3) of the Exchange Act) other than the Company or one of its direct or indirect
wholly-owned subsidiaries; (2) the consummation of any transaction (including, without limitation, any merger or consolidation) as a result of which any “person” (as that term is used in Section 13(d)(3) of the Exchange Act)
becomes the “beneficial owner” (as defined in Rules 13d-3 and 13d-5 under the Exchange Act), directly or indirectly, of more than 50% of the Company’s
outstanding Voting Stock or other Voting Stock into which the Company’s Voting Stock is reclassified, consolidated, exchanged or changed, measured by voting power rather than number of shares; (3) the Company consolidates with, or merges
with or into, any “person” or “group” (as that term is used in Section 13(d)(3) of the Exchange Act), or any “person” or “group” consolidates with, or merges with or into, the Company, in any such event
pursuant to a 

  
 2 

 
transaction in which any of the Company’s Voting Stock or the Voting Stock of such other person is converted into or exchanged for cash, securities or other property, other than any such
transaction where the shares of the Company’s Voting Stock outstanding immediately prior to such transaction constitute, or are converted into or exchanged for, a majority of the Voting Stock of the surviving person or any direct or indirect
parent company of the surviving person immediately after giving effect to such transaction; or (4) the adoption of a plan relating to the Company’s liquidation or dissolution. Notwithstanding the foregoing, a transaction will not be deemed
to involve a Change of Control if (a) the Company becomes a direct or indirect wholly-owned subsidiary of a holding company (which shall include a parent company) and (b)(i) the holders of the Voting Stock of such holding company immediately
following that transaction are substantially the same as the holders of the Voting Stock of the Company immediately prior to that transaction or (ii) no “person” (as that term is used in Section 13(d)(3) of the Exchange Act)
(other than a holding company satisfying the requirements of this sentence) becomes the “beneficial owner” (as defined in Rules 13d-3 and 13d-5 under the
Exchange Act), directly or indirectly, of more than 50% of the voting power of the Voting Stock of such holding company immediately following such transaction. 

“Change of Control Triggering Event” means, with respect to any series of Notes, the occurrence of both a Change of Control
and a Below Investment Grade Rating Event. 
 “Common Depositary” means The Bank of New York Mellon, London Branch, as
common depositary for the Depositary. 
 “Comparable Bond Rate” means, for any Optional Redemption Date, the rate per annum
equal to the annual equivalent yield to maturity or interpolated yield to maturity (on a day count basis), computed as of the third Business Day immediately preceding that Optional Redemption Date, of the Comparable Government Issue, assuming a
price for the Comparable Government Issue (expressed as a percentage of its principal amount) equal to the Comparable Price for that Optional Redemption Date. 

“Comparable Government Issue” means, with respect to any series of Notes to be redeemed, the euro-denominated security issued
by the German government selected by an Independent Investment Banker as having an actual or interpolated maturity comparable to the remaining term of the Notes to be redeemed (assuming that such Notes to be redeemed matured on their applicable Par
Call Date) that would be utilized, at the time of selection and in accordance with customary financial practice, in pricing new issues of corporate debt securities of comparable maturity to the remaining term of the Notes to be redeemed. 

“Comparable Price” means, with respect to any Optional Redemption Date, (a) the average of the Reference Dealer
Quotations for such Optional Redemption Date, after excluding the highest and lowest of the Reference Dealer Quotations, (b) if the Company obtains fewer than four Reference Dealer Quotations, the arithmetic average of those quotations or
(c) if the Company obtains only one Reference Dealer Quotation, such Reference Dealer Quotation. 

  
 3 

 “Depositary” means each of Clearstream Banking, S.A. and Euroclear Bank
SA/NV as operator of the Euroclear System. 
 “euro” or “€” means the single currency introduced at
the third stage of the European Economic and Monetary Union pursuant to the Treaty establishing the European Community, as amended. 

“Fitch” means Fitch Ratings, Limited, and any successor to its rating agency business. 

“ICMA” means the International Capital Markets Association. 

“Independent Investment Banker” means any Reference Dealer appointed by the Company as Independent Investment Banker
(initially, Merrill Lynch International). 
 “Internal Revenue Code” means the U.S. Internal Revenue Code of 1986, as
amended. 
 “Investment Grade Rating” means a rating by Moody’s equal to or higher than Baa3 (or the equivalent under
a successor rating category of Moody’s) or a rating by S&P equal to or higher than BBB- (or the equivalent under any successor rating category of S&P) or a rating by Fitch equal to or higher than BBB- (or the equivalent under any successor rating category of Fitch). 
 “Moody’s”
means Moody’s Investors Service, Inc., and any successor to its rating agency business. 
 “Optional Redemption Date”
when used with respect to any Note to be redeemed at the Company’s option, means the date fixed for such redemption by or pursuant to Section 1.3 of this Supplemental Indenture. 

“Optional Redemption Price” when used with respect to any Note to be redeemed at the Company’s option, means the price
at which it is to be redeemed pursuant to Section 1.3 of this Supplemental Indenture. 
 “Par Call Date” means
February 1, 2025 in the case of the 2025 Notes; December 1, 2027 in the case of the 2028 Notes; July 1, 2031 in the case of the 2031 Notes; April 1, 2039 in the case of the 2039 Notes; and April 1, 2049 in the case of the
2049 Notes. 
 “Paying Agency Agreement” means the Paying Agency Agreement, dated as of September 30, 2019, between
the Company and the Paying Agent. 
 “Paying Agent” means The Bank of New York Mellon, London Branch, or any successor.

  
 4 

 “Primary Bond Dealer” means a broker or dealer of, and/or a market maker
in, German government bonds. 
 “Rating Agencies” means (1) Moody’s, S&P and Fitch; and (2) if any of
Moody’s, S&P or Fitch ceases to rate the applicable series of Notes or fails to make a rating of such Notes publicly available for any reason, a “nationally recognized statistical rating organization” within the meaning of
Section 3(a)(62) of the Exchange Act, selected by the Company (as certified by a resolution of its Board of Directors) as a replacement agency for any of Moody’s, S&P or Fitch, or all of them, as the case may be. 

“Reference Dealer” means each of (i) Merrill Lynch International, Goldman Sachs & Co. LLC, Citigroup Global
Markets Limited and J.P. Morgan Securities plc and their respective affiliates or successors and (ii) one other nationally recognized investment banking firm (or its affiliate) that is a Primary Bond Dealer that the Company selects in
connection with the particular redemption, and each of their respective successors, provided that if at any time any of the above is not a Primary Bond Dealer, the Company will substitute that entity with another nationally recognized
investment banking firm that the Company selects that is a Primary Bond Dealer. 
 “Reference Dealer Quotations” means,
with respect to each Reference Dealer and any Optional Redemption Date, the arithmetic average, as determined by the Independent Investment Banker, of the bid and asked prices for the Comparable Government Issue (expressed in each case as a
percentage of its principal amount) quoted in writing to the Independent Investment Banker by such Reference Dealer at 11:00 a.m., London time, on the third Business Day preceding such Optional Redemption Date. 

“Remaining Scheduled Payments” means, with respect to each Note to be redeemed, the remaining scheduled payments of the
principal thereof and interest thereon that would be due after the related Optional Redemption Date but for such redemption (assuming that such Note to be redeemed matured on its applicable Par Call Date); provided, however, that, if such
Optional Redemption Date is not an interest payment date with respect to such Note, the amount of the next succeeding scheduled interest payment thereon will be reduced by the amount of interest accrued thereon to such Optional Redemption Date. 

“S&P” means S&P Global Ratings, a division of S&P Global, Inc., and any successor to its rating agency business.

 “Specified Office of the Paying Agent” means, initially, the London Branch of The Bank of New York Mellon, located at
One Canada Square, London E14 5AL, England. 
 “Treasury Regulations” means the U.S. Treasury Regulations promulgated under
the Internal Revenue Code. 

  
 5 

 “United States person” means any individual who is a citizen or resident of
the United States for U.S. federal income tax purposes, a corporation, partnership or other entity created or organized in or under the laws of the United States, any state of the United States or the District of Columbia (other than a partnership
that is not treated as a United States person under any applicable Treasury Regulations), or any estate or trust the income of which is subject to United States federal income taxation regardless of its source. 

“United States” means the United States of America, the states of the United States, and the District of Columbia. 

Section 1.2    Terms of the Notes. 

The following terms relate to the Notes: 

(1)    The 2025 Notes shall constitute a separate series of Notes having the title “0.125% Senior Notes due
2025,” the 2028 Notes shall constitute a separate series of Notes having the title “0.500% Senior Notes due 2028,” the 2031 Notes shall constitute a separate series of Notes having the title “0.875% Senior Notes due 2031,”
the 2039 Notes shall constitute a separate series of Notes having the title “1.500% Senior Notes due 2039” and the 2049 Notes shall constitute a separate series of Notes having the title “1.875% Senior Notes due 2049.” 

(2)    The aggregate principal amount of the 2025 Notes (the “Initial 2025 Notes”), the 2028 Notes (the
“Initial 2028 Notes”), the 2031 Notes (the “Initial 2031 Notes”), the 2039 Notes (the “Initial 2039 Notes”) and the 2049 Notes (the “Initial 2049 Notes,” and, together with the
Initial 2025 Notes, the Initial 2028 Notes, the Initial 2031 Notes and the Initial 2039 Notes, the “Initial Notes”) that may be initially authenticated and delivered under the Indenture shall be €800,000,000, €800,000,000,
€900,000,000, €900,000,000 and €1,000,000,000, respectively. The Company may from time to time, without the consent of the Holders of any series of Notes, issue additional 2025 Notes (in any such case, the “Additional 2025
Notes”), additional 2028 Notes (in any such case, the “Additional 2028 Notes”), additional 2031 Notes (in any such case, the “Additional 2031 Notes”), additional 2039 Notes (in any such case, the
“Additional 2039 Notes”) and additional 2049 Notes (in any such case, the “Additional 2049 Notes” and, together with the Additional 2025 Notes, the Additional 2028 Notes, the Additional 2031 Notes and the Additional
2039 Notes, the “Additional Notes”) having the same terms (except for the issue date, offering price and, if applicable, the first interest payment date) as the Initial 2025 Notes, Initial 2028 Notes, Initial 2031 Notes, Initial
2039 Notes and the Initial 2049 Notes, as the case may be. Any Additional Notes of a series and the Initial Notes of such series shall constitute a single series under the Indenture; provided that if any Additional Notes of a series are not
fungible with the Initial Notes of such series for U.S. federal income tax purposes, such Additional Notes of such series shall not have the same ISIN or Common Code as the Initial Notes of such series. All references to a series of Notes shall
include both the Initial Notes and any Additional Notes of such series, unless the context otherwise requires. The aggregate principal amount of each of the 2025 Notes, the 2028 Notes, the 2031 Notes, the 2039 Notes and the 2049 Notes shall be
unlimited. The entire respective Outstanding principal amount of the 

  
 6 

 
2025 Notes, the 2028 Notes, the 2031 Notes, the 2039 Notes and the 2049 Notes shall be payable on March 1, 2025, March 1, 2028, October 1, 2031, October 1, 2039 and
October 1, 2049, respectively. The principal of each Note payable at maturity or upon earlier redemption shall be paid against presentation and surrender of such Note at the office or agency maintained for such purposes in London, initially,
the Specified Office of the Paying Agent. 
 (3)    The rate at which the 2025 Notes shall bear interest shall be 0.125%
per annum, the rate at which the 2028 Notes shall bear interest shall be 0.500% per annum, the rate at which the 2031 Notes shall bear interest shall be 0.875% per annum, the rate at which the 2039 Notes shall bear interest shall be 1.500% per annum
and the rate at which the 2049 Notes shall bear interest shall be 1.875% per annum. The date from which interest shall accrue on the Notes shall be the most recent Interest Payment Date to which interest has been paid or provided for or, if no
interest has been paid, from September 30, 2019. The Interest Payment Dates for the 2025 Notes and the 2028 Notes shall be March 1 of each year, beginning on March 1, 2020 until the principal is paid or made available for payment, and
the Interest Payment Dates for the 2031 Notes, the 2039 Notes and the 2049 Notes shall be October 1 of each year, beginning on October 1, 2020 until the principal is paid or made available for payment; provided that if any Interest
Payment Date for any series of Notes falls on a day that is not a Business Day, the required payment shall be made on the next Business Day as if it were made on the date the payment to Holders was due and no interest shall accrue on the amount so
payable for the period from and after that Interest Payment Date. The regular record date shall be the 15th calendar day, whether or not a Business Day, immediately preceding the related Interest
Payment Date. Interest on the Notes shall be computed on the basis of an ACTUAL/ACTUAL (ICMA) (as defined in the rulebook of ICMA) day count convention. 

(4)    The Notes shall be issuable in whole in the form of one or more registered Global Securities, without coupons,
which shall be deposited with, or on behalf of, the applicable Depositary and shall be registered in the name of the Common Depositary for, and in respect of interests held through, the applicable Depositary. Each Note shall be substantially in the
form attached hereto as Exhibit A, the terms of which are herein incorporated by reference. The Notes shall be issuable in denominations of €100,000 or any integral multiple of €1,000 in excess thereof. 

(5)    The Notes may be redeemed at the option of the Company prior to the maturity date, as provided in Section 1.3
hereof. 
 (6)    The Notes shall not have the benefit of any sinking fund. 

(7)    Except as provided herein, the Holders shall have no special rights in addition to those provided in the Base
Indenture upon the occurrence of any particular events. 
 (8)    The Notes shall be general unsecured and
unsubordinated obligations of the Company and shall be ranked equally among themselves. 

  
 7 

 (9)    The Notes are not convertible into shares of common stock or
other securities of the Company. 
 (10)    The covenants set forth in Section 1.4 hereof shall be applicable to
the Notes. 
 (11)    The transfer and exchange provisions set forth in Section 2.05 of the Base Indenture shall be
applicable to the Notes. 
 (12)    All payments of principal of, and interest (including Additional Amounts, if any)
and premium (if any) on, the Notes shall be payable in euro; provided, however, that if, on or after September 24, 2019, euro is unavailable to the Company due to the imposition of exchange controls or other circumstances beyond the
Company’s control or if the euro is no longer being used by the then member states of the European Economic and Monetary Union that have adopted the euro as their currency or for the settlement of transactions by public institutions of or
within the international banking community, then all payments in respect of the Notes shall be made in U.S. dollars until the euro is again available to the Company or so used. In such circumstances, the amount payable on any date in euro shall be
converted into U.S. dollars at the rate mandated by the U.S. Federal Reserve Board as of the close of business on the second Business Day prior to the relevant payment date or, in the event the U.S. Federal Reserve Board has not mandated a rate of
conversion, on the basis of the most recent U.S. dollar/euro exchange rate published in The Wall Street Journal on or prior to the second Business Day prior to the relevant payment date. Any payment in respect of the Notes so made in U.S. dollars
shall not constitute an Event of Default under the Notes or the Indenture. Neither the Trustee nor the Paying Agent shall have any responsibility for any calculation or conversion in connection with the foregoing. Any references elsewhere in the
Indenture or the Notes to payments being made in euro notwithstanding, payments shall be made in U.S. dollars to the extent set forth in this Section 1.2(12). 

(13)    The Bank of New York Mellon, London Branch, shall initially act as the Paying Agent in accordance with the terms
of the Paying Agency Agreement. The Company hereby initially designates the Specified Office of the Paying Agent as the office to be maintained by it where Notes may be presented for payment, registration of transfer or exchange, and where notices
to or demands upon the Company in respect of the Notes or the Indenture may be served. The Security Registrar for the Notes shall initially be the Trustee. Upon notice to the Trustee, the Company may at any time vary or terminate the appointment of
any Paying Agent or Security Registrar, to appoint additional or other Paying Agents or Security Registrars and to approve any change in the office through which any Paying Agent or Security Registrar acts. 

(14)    In order to provide for all payments due on the Notes as the same shall become due, the Company shall cause to be
paid to the Paying Agent, no later than 10:00 a.m. London time on the Business Day prior to the payment date of each Note, at such bank as the Paying Agent shall previously have notified the Company, in immediately available funds sufficient to meet
all payments due on such Notes. 

  
 8 

 (15)    Notwithstanding any other provision of this Supplemental
Indenture, the Trustee and Paying Agent shall be entitled to make a deduction or withholding from any payment which it makes under this Supplemental Indenture for or on account of any present or future taxes, duties or charges if and to the extent
so required by any applicable law and any current or future regulations or agreements thereunder or official interpretations thereof or any law implementing an intergovernmental approach thereto or by virtue of the relevant Holder failing to satisfy
any certification or other requirements in respect of the Notes, in which event the Trustee or Paying Agent shall make such payment after such withholding or deduction has been made and shall account to the relevant authorities for the amount so
withheld or deducted and shall have no obligation to gross up any payment hereunder or pay any additional amount as a result of such withholding tax. 

Section 1.3    Optional Redemption. 

(a)    The provisions of Article III of the Base Indenture, as amended by the provisions of this Supplemental Indenture,
shall apply to the Notes with respect to this Section 1.3. 
 (b)    Prior to their applicable Par Call Date, the
Notes of any series shall be redeemable, in whole at any time or in part from time to time, at the Company’s option. Upon redemption of the Notes of any series, the Company shall pay an Optional Redemption Price equal to the greater of: 

 

	 	(i)	 100% of the principal amount of the Notes to be redeemed, and 

 

	 	(ii)	 the sum of the present values of the Remaining Scheduled Payments of the Notes to be redeemed, discounted to
the Optional Redemption Date on an annual basis (ACTUAL/ACTUAL (ICMA)) using a discount rate equal to the Comparable Bond Rate, plus 20 basis points, in the case of the 2025 Notes, 20 basis points, in the case of the 2028 Notes, 25 basis points, in
the case of the 2031 Notes, 30 basis points, in the case of the 2039 Notes, and 35 basis points, in the case of the 2049 Notes; 

plus, in each case, in addition to such Optional Redemption Price, accrued and unpaid interest on the Notes being redeemed, if any, to, but excluding,
the Optional Redemption Date. 
 On and after the applicable Par Call Date, the Notes of each series shall be redeemable, in whole at any
time or in part from time to time, at the Company’s option, at an Optional Redemption Price equal to 100% of the principal amount of the Notes to be redeemed, plus accrued and unpaid interest, if any, to, but excluding, the Optional Redemption
Date. 
 (c)    The Notes of any series shall also be redeemable, in whole, but not in part, at any time at the
Company’s option, at an Optional Redemption Price equal to 100% of the principal amount of the Notes, plus, accrued and unpaid interest and any Additional Amounts thereon, if the Company determines that (A) as a result of any change or
amendment to the laws, treaties, 

  
 9 

 
regulations or rulings of the United States of America or any political subdivision or taxing authority thereof, which change or amendment is announced and becomes effective on or after
September 24, 2019, there is a material probability that the Company has or will become obligated to pay Additional Amounts of such series or (B) on or after September 24, 2019, any change in the official application, enforcement or
interpretation of those laws, treaties, regulations or rulings, including a holding by a court of competent jurisdiction in the United States or any other action, taken by any taxing authority or a court of competent jurisdiction in the United
States, whether or not such action was taken or made with respect to the Company, results in a material probability that the Company has or will become obligated to pay Additional Amounts on any Notes of such series; provided that the Company
determines, in its business judgment, that the obligation to pay such Additional Amounts cannot be avoided by use of reasonable measures available to the Company, not including substitution of the obligor under such Notes. Prior to the mailing of
any notice of such a redemption, the Company shall deliver to the Trustee (1) an Officer’s Certificate stating that the Company is entitled to effect such a redemption and setting forth a statement of facts showing that the conditions
precedent to the right of the Company to so redeem have occurred and (2) an Opinion of Counsel to such effect based on such statement of facts. 

(d)    Notwithstanding the foregoing, installments of interest whose Stated Maturity is on or prior to the Optional
Redemption Date shall be payable on the applicable Interest Payment Date to the Holders of such Notes registered as such at the close of business on the applicable regular record date pursuant to the Notes and the Indenture. 

(e)    On and after the applicable Optional Redemption Date for any series of Notes, interest shall cease to accrue on the
Notes to be redeemed or any portion thereof called for redemption, unless the Company defaults in the payment of the Optional Redemption Price and accrued and unpaid interest and Additional Amounts, if any. No later than 10:00 a.m. London time on
the Business Day prior to the Optional Redemption Date for any Notes to be redeemed, the Company shall deposit with the Trustee or Paying Agent, funds sufficient to pay the Optional Redemption Price of such Notes on the Optional Redemption Date, and
(except if the date fixed for redemption shall be an Interest Payment Date) accrued and unpaid interest and Additional Amounts, if any. If less than all of a series of Notes are to be redeemed, the Notes to be redeemed shall be selected, in the case
of global securities, in accordance with applicable Depositary procedures and, in the case of definitive securities in a manner the trustee deems fair and appropriate, unless otherwise required by law or applicable stock exchange requirements. 

(f)    Notice of any optional redemption shall be transmitted at least 15 days but not more than 60 days before the
applicable Optional Redemption Date to each Holder of the Notes to be redeemed; provided, however, that the Company shall notify the Trustee of the Optional Redemption Date at least 15 days prior to the date of the giving of such notice
(unless a shorter notice shall be satisfactory to the Trustee). Any notice may, at the Company’s discretion, be subject to the satisfaction or waiver of one or more conditions precedent. In that case, the notice shall state the nature of such
condition precedent. Such notice shall be provided in accordance with Section 3.02 of the Base Indenture. If the Optional Redemption Price cannot be determined 

  
 10 

 
at the time such notice is to be given, the actual Optional Redemption Price applicable to the Notes that are being redeemed, calculated as described above in clause (b), shall be set forth in an
Officers’ Certificate of the Company delivered to the Trustee no later than two (2) Business Days prior to the Optional Redemption Date. Notice of redemption having been given as provided in the Indenture, the Notes called for redemption
shall (subject to the satisfaction or waiver of any applicable condition precedent), on the Optional Redemption Date, become due and payable at the Optional Redemption Price, plus accrued and unpaid interest and Additional Amounts, if any, to, but
excluding, the Optional Redemption Date. 
 Section 1.4    Additional Covenants. 

The following additional covenants shall apply with respect to the Notes so long as any of the Notes remain Outstanding: 

(1)    Change of Control Triggering Event. 

(a)    If a Change of Control Triggering Event occurs with respect to any series of the Notes, unless the Company shall
have redeemed such series of the Notes in full, as set forth in Section 1.3 of this Supplemental Indenture or the Company shall have defeased such series of the Notes or have satisfied and discharged such series of the Notes, as set forth in
Article XI of the Base Indenture, the Company shall make an offer (a “Change of Control Offer”) to each Holder of the applicable series of the Notes to repurchase any and all of such Holder’s Notes of such series at a
repurchase price in cash equal to 101% of the aggregate principal amount of the Notes to be repurchased (such principal amount to be equal to €100,000 or any integral multiple of €1,000 in excess thereof), plus accrued and unpaid interest,
if any, on the Notes to be repurchased up to, but excluding, the date of repurchase (the “Change of Control Payment”). Within 30 days following any Change of Control Triggering Event, notice shall be delivered to the Holders of
Notes of such series describing the transaction or transactions that constitute the Change of Control Triggering Event and offering to repurchase such Notes on the date specified in the notice, which date will be no earlier than 15 days and no later
than 60 days from the date such notice is delivered (the “Change of Control Payment Date”). Notwithstanding the foregoing, installments of interest whose Stated Maturity is on or prior to the Change of Control Payment Date shall be
payable on the applicable Interest Payment Date to the Holders of such Notes registered as such at the close of business on the applicable regular record date pursuant to the Notes and the Indenture. 

(b)    On the Change of Control Payment Date, the Company shall, to the extent lawful: 

 

	 	(i)	 accept for payment all Notes or portions of Notes of the applicable series properly tendered pursuant to the
Change of Control Offer; 

  

	 	(ii)	 deposit with the Trustee or a paying agent an amount equal to the Change of Control Payment in respect of all
Notes or portions of Notes of the applicable series properly tendered; and 

  
 11 

	 	(iii)	 deliver or cause to be delivered to the Trustee the Notes properly accepted, together with an Officer’s
Certificate stating (1) the aggregate principal amount of such series of Notes or portions of such series of Notes being repurchased, (2) that all conditions precedent contained herein to make a Change of Control Offer have been complied
with and (3) that the Change of Control Offer has been made in compliance with the Indenture. 

 The Company shall
comply in all material respects with the requirements of Rule 14e-1 under the Exchange Act and any other securities laws and regulations thereunder to the extent such laws and regulations are applicable in
connection with the repurchase of the Notes as a result of a Change of Control Triggering Event. To the extent that the provisions of any such securities laws or regulations conflict with this Section 1.4, the Company shall comply with the
applicable securities laws and regulations and shall not be deemed to have breached its obligations under this Section 1.4 by virtue of any such conflict. 

(2)    Additional Amounts. 

(a)    All payments of principal and interest in respect of the Notes shall be made free and clear of, and without
deduction or withholding for or on account of any present or future taxes, duties, assessments or other governmental charges of whatsoever nature imposed, levied, collected, withheld or assessed by the United States or any political subdivision or
taxing authority of or in the United States, unless such withholding or deduction is required by law. 
 (b)    The
Company shall pay to a Holder who is not a United States person additional amounts as may be necessary so that every net payment of the principal of and premium, if any, and interest on the Notes to such Holder, after deduction or withholding for or
on account of any present or future tax, assessment or other governmental charge imposed upon such Holder by the United States of America or any taxing authority thereof or therein, shall not be less than the amount provided in the Note to be then
due and payable (such amounts, the “Additional Amounts”); provided, however, that the Company shall not be required to make any payment of Additional Amounts for or on account of: 

 

	 	(i)	 any tax, assessment or other governmental charge that would not have been imposed but for (A) the
existence of any present or former connection (other than a connection arising solely from the ownership of those Notes or the receipt of payments in respect of those Notes) between that Holder (or the beneficial owner for whose benefit such Holder
holds such Notes), or between a fiduciary, settlor, beneficiary of, member or shareholder of, or possessor of a power over, that Holder or beneficial owner, if that Holder or beneficial owner is an estate, trust, partnership or corporation, and the
United States, including that Holder or beneficial owner, or that fiduciary, settlor, beneficiary, member, shareholder or possessor being or having been a citizen or resident or treated as a resident of the United States or being or having been
engaged in trade or business 

  
 12 

	 	
or present in the United States or having had a permanent establishment in the United States or (B) the presentation of a debt security for payment on a date more than 30 days after the
later of the date on which that payment becomes due and payable and the date on which payment is duly provided for; 

  

	 	(ii)	 any estate, inheritance, gift, sales, transfer, excise, personal property, wealth, capital gains, interest
equalization or similar tax, assessment or other governmental charge; 

  

	 	(iii)	 any tax, assessment or other governmental charge imposed on foreign personal holding company income or by
reason of a Holder (or the beneficial owner for whose benefit such Holder holds such Notes), or a fiduciary, settlor, beneficiary of, member or shareholder of, or possessor of a power over, the Holder or beneficial owner, if that Holder or
beneficial owner is an estate, trust, partnership or corporation, being or having been a passive foreign investment company, a controlled foreign corporation, a foreign tax exempt organization or a personal holding company with respect to the United
States or a corporation that accumulates earnings to avoid U.S. federal income tax; 

  

	 	(iv)	 any tax, assessment or other governmental charge which is payable otherwise than by withholding from payment of
principal of or premium, if any, or interest on the Notes of that Holder; 

  

	 	(v)	 any tax, assessment or other governmental charge required to be withheld by any paying agent from any payment
of principal of or premium, if any, or interest on the Notes of that Holder if such payment can be made without withholding by any other paying agent; 

  

	 	(vi)	 any tax, assessment or other governmental charge which would not have been imposed but for the failure of a
Holder (or the beneficial owner for whose benefit such Holder holds the Notes), or a fiduciary, settlor, beneficiary of, member or shareholder of, or possessor of power over, the holder or beneficial owner, if that Holder or beneficial owner is an
estate, trust, partnership or corporation, or any intermediary through which a beneficial owner holds Notes to comply with certification, information, documentation or other reporting requirements concerning the nationality, residence, identity or
connections with the United States of America of the beneficial owner or any Holder (including, but not limited to, the requirement to provide Internal Revenue Service Forms W-8BEN, Forms W-8BEN-E, Forms W-8ECI, or any subsequent versions thereof or successor thereto, and including, without limitation, any documentation
requirement under an applicable income tax treaty); 

  
 13 

	 	(vii)	 any tax, assessment or other governmental charge imposed as a result of a Holder (or the beneficial owner for
whose benefit such Holder holds such Notes), or a fiduciary, settlor, beneficiary of, member or shareholder of, or possessor of a power over, the Holder or beneficial owner, if that Holder or beneficial owner is an estate, trust, partnership or
corporation, being or having been (A) a 10% shareholder (as defined in Section 871(h)(3)(B) of the Internal Revenue Code, and the regulations that may be promulgated thereunder) of the Company or (B) a controlled foreign corporation
that is related to the Company within the meaning of Section 864(d)(4) of the Internal Revenue Code or (C) a bank receiving interest described in Section 881(c)(3)(A) of the Internal Revenue Code; 

 

	 	(viii)	 any tax, assessment or other governmental charge that would not have been imposed but for a change in law,
regulation, or administrative or judicial interpretation that becomes effective more than 15 days after the payment becomes due or is duly provided for, whichever occurs later; 

 

	 	(ix)	 any taxes payable under Sections 1471 through 1474 of the Internal Revenue Code (or any amended or successor
version of such Sections), any current or future regulations or other guidance thereunder, or any agreement (including any intergovernmental agreement) entered into in connection therewith; or 

 

	 	(x)	 any combination of items (i), (ii), (iii), (iv), (v), (vi), (vii), (viii) and (ix) above;

 nor shall any Additional Amounts be paid to any Holder that is not the sole beneficial owner of the Notes, or a
portion of the Notes, or that is a fiduciary, partnership or limited liability company to the extent that a beneficial owner with respect to the Holder, a beneficiary or settlor with respect to the fiduciary or a member of that partnership, limited
liability company or a beneficial owner thereof would not have been entitled to the payment of those Additional Amounts had that beneficiary, settlor, member or beneficial owner received directly its beneficial or distributive share of the payment.

 Section 1.5    Events of Default. 

(a)    The provisions of Article VI of the Base Indenture shall be applicable to each series of the Notes, except that
clauses (1) through (7) of Section 6.01(a) shall be modified with respect to Notes of a series as follows: 

(1)    default in the payment of the principal or any premium on such series of Notes when due (whether at
maturity, upon acceleration, redemption or otherwise); 

  
 14 

 (2)    default for 30 days in the payment of interest on
the Notes of such series when due; 
 (3)    (i) failure by the Company to comply with
Section 1.4(1) of this Supplemental Indenture with respect to such series or (ii) failure by the Company to observe or perform any term of the Indenture applicable to such series of Notes (other than those referred to in (1) or (2)
above or (3)(i) above) for a period of 90 days after the Company receives a notice of default stating that the Company is in breach. The notice required under 3(ii) above must be sent by either the Trustee or Holders of 25% of the principal amount
of the applicable series of Notes; 
 (4)    (A) failure by the Company to pay indebtedness for money
borrowed by the Company or for which the Company has guaranteed the payment, in an aggregate principal amount of at least $150,000,000, at the later of final maturity and the expiration of any related applicable grace period and such defaulted
payment shall not have been made, waived or extended within 30 days or (B) acceleration of the maturity of any indebtedness for money borrowed by the Company or for which the Company has guaranteed the payment, in an aggregate principal amount
of at least $150,000,000, if such indebtedness has not been discharged in full or such acceleration has not been rescinded or annulled within 30 days; provided, however, that, if the default under the instrument is cured by the
Company, or waived by the holders of the indebtedness, in each case as permitted by the governing instrument, then the Event of Default under the Indenture caused by such default will be deemed likewise to be cured or waived; 

(5)    the entry by a court having competent jurisdiction of: 

(A)    an order for relief in respect of the Company as debtor in an involuntary proceeding under any
applicable Bankruptcy Law and such order shall remain unstayed and in effect for a period of 60 consecutive days; or 

(B)    a final and non-appealable order appointing a Custodian of
the Company, or ordering the winding up or liquidation of the affairs of the Company, and such order shall remain unstayed and in effect for a period of 60 consecutive days; or 

(6)    the commencement by the Company of a voluntary proceeding under any applicable Bankruptcy Law or the
consent by the Company as debtor to the entry of a decree or order for relief in an involuntary proceeding under any applicable Bankruptcy Law, or the filing by the Company as debtor of a consent to an order for relief in any involuntary proceeding
under any Bankruptcy Law, or to the appointment of a Custodian or the making by the Company of an assignment for the benefit of creditors. 

  
 15 

 ARTICLE II 

MISCELLANEOUS 

Section 2.1    Business Day. 

If any maturity date or earlier date of redemption for any series of Notes falls on a day that is not a Business Day, the required payment
shall be made on the next Business Day as if it were made on the date the payment to Holders was due and no interest shall accrue on the amount so payable for the period from and after that maturity date or that date of redemption, as the case may
be. 
 Section 2.2    [Reserved]. 

Section 2.3    Confirmation of Indenture. 

The Base Indenture, as supplemented and amended by this Supplemental Indenture, is in all respects ratified and confirmed, and the Base
Indenture, this Supplemental Indenture and all indentures supplemental thereto shall be read, taken and construed as one and the same instrument. 

Section 2.4    Concerning the Trustee. 

In carrying out its responsibilities hereunder, the Trustee shall have all of the rights, protections and immunities which it possesses under
the Indenture. The recitals contained herein and in the Notes, except the Trustee’s certificate of authentication, shall be taken as the statements of the Company, and the Trustee assumes no responsibility for their correctness. The Trustee
makes no representations as to the validity or sufficiency of this Supplemental Indenture or of the Notes. The Trustee shall not be accountable for the use or application by the Company of the Notes or the proceeds thereof. 

Section 2.5    Governing Law. 

This Supplemental Indenture and the Notes shall be deemed to be a contract made under the internal laws of the State of New York, and for all
purposes shall be construed in accordance with the laws of said State. 
 Section 2.6    Separability.

 In case any provision in this Supplemental Indenture shall for any reason be held to be invalid, illegal or unenforceable, the validity,
legality and enforceability of the remaining provisions shall not in any way be affected or impaired thereby. 

  
 16 

 Section 2.7    Counterparts. 

This Supplemental Indenture may be executed in any number of counterparts each of which shall be an original, but such counterparts shall
together constitute but one and the same instrument. 
 Section 2.8    No Benefit. 

Nothing in this Supplemental Indenture, express or implied, shall give to any Person other than the parties hereto and their successors or
assigns, and the Holders, any benefit or legal or equitable rights, remedy or claim under this Supplemental Indenture or the Base Indenture. 

  
 17 

 IN WITNESS WHEREOF, the parties hereto have caused this Supplemental Indenture to be duly
executed all as of the day and year first above written. 
  

					
		 	THERMO FISHER SCIENTIFIC INC.
			
		 	By:	 	 /s/ Anthony H. Smith

		 	Name:	 	Anthony H. Smith
		 	Title:	 	Vice President, Tax and Treasury and Treasurer

 [Eighteenth Supplemental Indenture] 

  THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A., as Trustee 

 

					
			
		 	By:	 	 /s/ Karen Yu

		 	Name:	 	Karen Yu
		 	Title:	 	Vice President

 [Eighteenth Supplemental Indenture] 

 EXHIBIT A 

[Insert the Global Security legend, if applicable] 

[    ]%1 SENIOR NOTES DUE [    ]2 
  

			
	No. [    ]	  	€[    ]                    
	ISIN No. [    ]3	  	

 THERMO FISHER SCIENTIFIC INC. 

promises to pay to [    ] or registered assigns, the principal sum of [    ] Euro on [    ]4. 
 Interest Payment Date:
[    ]5 
 Record Date: [    ]6 
 Each holder of this Security (as defined below), by accepting the same, agrees to and
shall be bound by the provisions hereof and of the Indenture described herein, and authorizes and directs the Trustee described herein on such holder’s behalf to be bound by such provisions. Each holder of this Security hereby waives all notice
of the acceptance of the provisions contained herein and in the Indenture and waives reliance by such holder upon said provisions. 
 This
Security shall not be entitled to any benefit under the Indenture, or be valid or become obligatory for any purpose, until the Certificate of Authentication hereon shall have been signed by or on behalf of the Trustee. The provisions of this
Security are continued on the reverse side hereof, and such continued provisions shall for all purposes have the same effect as though fully set forth at this place. 

 

	1 	 2025 Notes: 0.125%; 2028 Notes: 0.500%; 2031 Notes: 0.875%; 2039 Notes: 1.500% and 2049 Notes: 1.875%

	2 	 2025 Notes: 2025; 2028 Notes: 2028; 2031 Notes: 2031; 2039 Notes: 2039 and 2049 Notes: 2049

	3 	 2025 Notes: XS2058556296; 2028 Notes: XS2058556536; 2031 Notes: XS2058556619; 2039 Notes: XS2058557260 and 2049
Notes: XS2058557344 

	4 	 2025 Notes: March 1, 2025; 2028 Notes: March 1, 2028; 2031 Notes: October 1, 2031; 2039 Notes:
October 1, 2039 and 2049 Notes: October 1, 2049 

	5 	 2025 Notes and 2028 Notes: March 1; and 2031 Notes, 2039 Notes and 2049 Notes: October 1

	6 	 2025 Notes and 2028 Notes: 15th calendar day immediately preceding the Interest Payment Date; and 2031 Notes,
2039 Notes and 2049 Notes: September 16 

  
 A-1 

 IN WITNESS WHEREOF, the Company has caused this instrument to be signed in accordance with Section 2.04
of the Base Indenture. 
 Date: [                    ]

  

			
	THERMO FISHER SCIENTIFIC INC.

 
			
		
	By:	 	  

	Name:	 	
	Title:	 	
		
	By:	 	  

	Name:	 	
	Title:	 	

  
 A-2 

 CERTIFICATE OF AUTHENTICATION 

This is one of the [    ]7 issued by Thermo Fisher Scientific Inc. of the series
designated therein, referred to in the within-mentioned Indenture. 
 Date:
[                    ] 
  

			
	THE BANK OF NEW YORK MELLON TRUST COMPANY, N.A. as Trustee
		
	By:	 	  

		 	Authorized Signatory

  

	7 	 2025 Notes: 0.125% Senior Notes due 2025; 2028 Notes: 0.500% Senior Notes due 2028; 2031 Notes: 0.875% Senior
Notes due 2031; 2039 Notes: 1.500% Senior Notes due 2039 and 2049 Notes: 1.875% Senior Notes due 2049 

  
 A-3 

 Thermo Fisher Scientific Inc. 

[    ]8 

This security is one of a duly authorized series of debt securities of Thermo Fisher Scientific Inc., a Delaware corporation (the “Company”),
issued or to be issued in one or more series under and pursuant to an Indenture for the Company’s unsubordinated debt securities, dated as of November 20, 2009 (the “Base Indenture”), duly executed and delivered by and
among the Company and The Bank of New York Mellon Trust Company, N.A., as trustee (the “Trustee”), as supplemented by the Eighteenth Supplemental Indenture, dated as of September 30, 2019 (the “Supplemental
Indenture”), between the Company and the Trustee. The Notes are subject to a Paying Agency Agreement, dated as of September 30, 2019 (the “Paying Agency Agreement”), between the Company and The Bank of New York Mellon,
London Branch, as paying agent (the “Paying Agent”). The Base Indenture as supplemented and amended by the Supplemental Indenture is referred to herein as the “Indenture.” By the terms of the Base Indenture, the
debt securities issuable thereunder are issuable in series that may vary as to amount, date of maturity, rate of interest and in other respects as provided in the Base Indenture. This security is one of the series designated on the face hereof
(individually, a “Security,” and collectively, the “Securities”), and reference is hereby made to the Indenture for a description of the rights, limitations of rights, obligations, duties and immunities of the
Trustee, the Company and the holders of the Securities (the “Securityholders”). Capitalized terms used herein and not otherwise defined shall have the meanings given them in the Base Indenture or the Supplemental Indenture, as
applicable. 
 1.    Interest. The Company promises to pay interest on the principal amount of this Security at
an annual rate of [    ]%9. The Company will pay interest annually in arrears on [    ]10 of each year
(each such day, an “Interest Payment Date”) until the principal is paid or made available for payment. If any Interest Payment Date, redemption date or maturity date of this Security is not a Business Day, then payment of interest
or principal (and premium, if any) shall be made on the next succeeding Business Day with the same force and effect as if made on the date such payment was due, and no interest shall accrue for the period after such date to the date of such payment
on the next succeeding Business Day. Interest on the Securities will accrue from the most recent date to which interest has been paid or duly made available for payment or, if no interest has been paid, from the date of issuance; provided
that, if there is no existing Default in the payment of interest, and if this Security is authenticated between a regular record date referred to on the face hereof and the next succeeding Interest Payment Date, interest shall accrue from such
next succeeding Interest Payment Date; and provided, further, that the first Interest Payment Date shall be [    ]11. Interest on the Securities shall be computed on the
basis of 
  

	8 	 2025 Notes: 0.125% Senior Notes due 2025; 2028 Notes: 0.500% Senior Notes due 2028; 2031 Notes: 0.875% Senior
Notes due 2031; 2039 Notes: 1.500% Senior Notes due 2039 and 2049 Notes: 1.875% Senior Notes due 2049 

	9 	 2025 Notes: 0.125%; 2028 Notes: 0.500%; 2031 Notes: 0.875%; 2039 Notes: 1.500% and 2049 Notes: 1.875%

	10 	 2025 Notes and 2028 Notes: March 1; and 2031 Notes, 2039 Notes and 2049 Notes: October 1

	11 	 2025 Notes and 2028 Notes: March 1, 2020; and 2031 Notes, 2039 Notes and 2049 Notes: October 1, 2020

  
 A-4 

 
an ACTUAL/ACTUAL (ICMA) (as defined in the rulebook of ICMA) day count convention. In order to provide for all payments due on the Securities as the same shall become due, the Company shall cause
to be paid to the Paying Agent, no later than 10:00 a.m. London time on the Business Day prior the payment date of each Security, at such bank as the Paying Agent shall previously have notified to the Company, in immediately available funds
sufficient to meet all payments due on such Securities. 
 2.    Method of Payment. The Company will pay interest
on the Securities (except defaulted interest), if any, to the persons in whose name such Securities are registered at the close of business on the regular record date referred to on the facing page of this Security for such interest installment. In
the event that the Securities or a portion thereof are called for redemption pursuant to an optional redemption or there is a Change of Control Offer, and the Optional Redemption Date or the Change of Control Payment Date, as applicable, is
subsequent to a regular record date with respect to any Interest Payment Date and prior to such Interest Payment Date, interest on such Securities shall instead be paid upon presentation and surrender of such Securities as provided in the Indenture.
Subject to Section 1.2 of the Supplemental Indenture, all payments of principal of, and interest (including Additional Amounts, if any) and premium (if any) on, the Securities shall be payable in euro. 

3.    Paying Agent and Registrar. Initially, The Bank of New York Mellon, London Branch, shall act as the Paying
Agent in accordance with the terms of the Paying Agency Agreement and the Trustee shall act as Security Registrar. Upon prior notice to the Trustee, the Company may change or appoint any Paying Agent or Security Registrar without notice to any
Securityholder. The Company or any of its Subsidiaries may act in any such capacity. 
 4.    Indenture. The
terms of the Securities include those stated in the Indenture and those made part of the Indenture by reference to the Trust Indenture Act of 1939, as amended (“TIA”), as in effect on the date the Indenture is qualified. The
Securities are subject to all such terms, and Securityholders are referred to the Indenture and TIA for a statement of such terms. In the event of a conflict between the terms of the Securities and the terms of the Indenture, the terms of the
Indenture shall prevail. The Securities are unsecured general obligations of the Company and constitute the series designated on the face hereof as the “[    ]12,”
initially limited to €[    ]13 in aggregate principal amount. The Company shall furnish to any Securityholder upon written request and without charge a copy of the Base
Indenture and the Supplemental Indenture. Requests may be made to: Thermo Fisher Scientific Inc., 168 Third Avenue, Waltham, Massachusetts 02451, Attention: Michael A. Boxer. 

 

	12 	 2025 Notes: 0.125% Senior Notes due 2025; 2028 Notes: 0.500% Senior Notes due 2028; 2031 Notes: 0.875% Senior
Notes due 2031; 2039 Notes: 1.500% Senior Notes due 2039 and 2049 Notes: 1.875% Senior Notes due 2049 

	13 	 2025 Notes: 800,000,000; 2028 Notes: 800,000,000; 2031 Notes: 900,000,000; 2039 Notes: 900,000,000 and 2049
Notes: 1,000,000,000 

  
 A-5 

 5.    Redemption. The Securities may be redeemed at the option of
the Company prior to the maturity date, as provided in Section 1.3 of the Supplemental Indenture. The Company shall not be required to make sinking fund payments with respect to the Securities. 

6.    Payment of Additional Amounts. All payments of principal and interest in respect of the Securities shall be
made free and clear of, and without deduction or withholding for or on account of any present or future taxes, duties, assessments or other governmental charges of whatsoever nature imposed, levied, collected, withheld or assessed by the United
States or any political subdivision or taxing authority of or in the United States, unless such withholding or deduction is required by law. The Company shall pay to a Holder of Securities who is not a United States person additional amounts as may
be necessary so that every net payment of the principal of and premium, if any, and interest on the Securities to such Holder, after deduction or withholding for or on account of any present or future tax, assessment or other governmental charge
imposed upon such Holder by the United States of America or any taxing authority thereof or therein, shall not be less than the amount provided in the Securities to be then due and payable (such amounts, the “Additional Amounts”);
provided, however, that the Company shall not be required to make any payment of Additional Amounts under certain circumstances provided in Section 1.4(2)(b) of the Supplemental Indenture. 

7.    Change of Control Triggering Event. Upon the occurrence of a Change of Control Triggering Event, unless the
Company has redeemed this Security or the Company has defeased this Security or satisfied and discharged this Security, the holder of this Security shall have the right to require that the Company purchase all or a portion (such principal amount to
be equal to €100,000 or any integral multiple of €1,000 in excess thereof) of this Security at a purchase price equal to 101% of the aggregate principal amount repurchased plus accrued and unpaid interest, if any, on the amount to be
repurchased up to but excluding the date of purchase. Within 30 days following any Change of Control Triggering Event, the Company shall send, by first class mail, a notice to each Holder, in accordance with Section 1.4(1)(a) of the
Supplemental Indenture, with a copy to the Trustee, which notice shall govern the terms of the Change of Control Offer. 

8.    Denominations, Transfer, Exchange. The Securities are in registered form without coupons in the denominations
of €100,000 or any integral multiple of €1,000 in excess thereof. The transfer of Securities may be registered and Securities may be exchanged as provided in the Indenture. The Securities may be presented for exchange or for registration
of transfer (duly endorsed or with the form of transfer endorsed thereon duly executed if so required by the Company or the Security Registrar) at the office of the Paying Agent or at the office of any transfer agent designated by the Company for
such purpose. No service charge shall be made for any registration of transfer or exchange, but a Securityholder may be required to pay any applicable taxes or other governmental charges. If the Securities are to be redeemed, the Company shall not
be required to: (i) issue, register the transfer of, or exchange any Security during a period beginning at the opening of business 15 days before the day of mailing of a notice of redemption of less than all of the outstanding Securities and
ending at the close of 

  
 A-6 

 
business on the day of such mailing; (ii) register the transfer of or exchange any Security or portions thereof selected for redemption, in whole or in part, except the unredeemed portions
of any such Security being redeemed in part; nor (iii) register the transfer of or exchange of a Security between the applicable record date and the next succeeding Interest Payment Date. 

9.    Persons Deemed Owners. The registered Securityholder may be treated as its owner for all purposes. 

10.    Repayment to the Company. Any funds or Governmental Obligations deposited with any paying agent or the
Trustee, or then held by the Company, in trust for payment of principal of, premium, if any, or interest on the Securities that are not applied but remain unclaimed by the holders of such Securities for at least one year after the date upon which
the principal of, premium, if any, or interest on such Securities shall have respectively become due and payable, shall be repaid to the Company, as applicable, or (if then held by the Company) shall be discharged from such trust. After return to
the Company, Holders entitled to the money or securities must look to the Company, as applicable, for payment as unsecured general creditors. 

11.    Amendments, Supplements and Waivers. The Indenture permits, with certain exceptions as therein provided, the
amendment thereof and the modification of the rights and obligations of the Company and the rights of the Holders of the Securities to be affected under the Indenture at any time by the Company and the Trustee with the consent of the Holders of a
majority in principal amount of the Securities at the time Outstanding to be affected. The Indenture also contains provisions permitting the Holders of a majority in principal amount of the Securities at the time Outstanding, on behalf of the
Holders of all Securities, to waive compliance by the Company with certain provisions of the Indenture and certain past defaults under the Indenture and their consequences. Any such consent or waiver by the Holder of this Security shall be
conclusive and binding upon such Holder and upon all future Holders of this Security and of any Security issued upon the registration of transfer hereof or in exchange herefor or in lieu hereof, whether or not notation of such consent or waiver is
made upon this Security. 
 12.    Defaults and Remedies. If an Event of Default with respect to the Securities
occurs and is continuing, the Trustee or the holders of at least 25% in aggregate principal amount of the Securities then Outstanding, by notice in writing to the Company (and to the Trustee if notice is given by such holders), may declare the
entire principal of, premium, if any, and accrued interest, if any, of such Securities due and payable immediately. Subject to the terms of the Indenture, if an Event of Default under the Indenture shall occur and be continuing, the Trustee shall be
under no obligation to exercise any of its rights or powers under the Indenture at the request or direction of any of the holders, unless such holders have offered the Trustee indemnity satisfactory to it. Upon satisfaction of certain conditions set
forth in the Indenture, the holders of a majority in principal amount of the Outstanding Securities shall have the right to direct the time, method and place of conducting any proceeding for any remedy available to the Trustee, or exercising any
trust or power conferred on the Trustee, with respect to the Securities. 

  
 A-7 

 13.    Trustee, Paying Agent and Security Registrar May Hold
Securities. The Trustee, subject to certain limitations imposed by the TIA, or any paying agent or Security Registrar, in its individual or any other capacity, may become the owner or pledgee of Securities with the same rights it would have if
it were not Trustee, paying agent or Security Registrar. 
 14.    No Recourse Against Others. No recourse under
or upon any obligation, covenant or agreement of the Indenture, or of any Security, or for any claim based thereon or otherwise in respect hereof or thereof, shall be had against any incorporator, stockholder, officer or director, past, present or
future as such, of the Company or of any predecessor or successor corporation, either directly or through the Company or any such predecessor or successor corporation, whether by virtue of any constitution, statute or rule of law, or by the
enforcement of any assessment or penalty or otherwise; it being expressly understood that the Indenture and the obligations issued hereunder and thereunder are solely corporate obligations, and that no such personal liability whatever shall attach
to, or is or shall be incurred by, the incorporators, stockholders, officers or directors as such, of the Company or of any predecessor or successor corporation, or any of them, because of the creation of the indebtedness authorized by the
Indenture, or under or by reason of the obligations, covenants or agreements contained in the Indenture or in the Securities or implied therefrom; and that any and all such personal liability of every name and nature, either at common law or in
equity or by constitution or statute, of, and any and all such rights and claims against, every such incorporator, stockholder, officer or director as such, because of the creation of the indebtedness authorized by the Indenture, or under or by
reason of the obligations, covenants or agreements contained in the Indenture or in the Securities or implied therefrom, are hereby expressly waived and released as a condition of, and as a consideration for, the acceptance of the Securities. 

15.    Discharge of Indenture. The Indenture contains certain provisions pertaining to discharge and defeasance,
which provisions shall for all purposes have the same effect as if set forth herein. 
 16.    Authentication.
This Security shall not be valid until the Trustee signs the certificate of authentication attached to the other side of this Security. 

17.    Additional Amounts. The Company is obligated to pay Other Additional Amounts on this Security to the extent
provided in Section 10.03 of the Base Indenture. 
 18.    Abbreviations. Customary abbreviations may be
used in the name of a Securityholder or an assignee, such as: TEN COM(= tenants in common), TEN ENT (= tenants by the entireties), JT TEN(= joint tenants with right of survivorship and not as tenants in common), CUST (= Custodian), and U/G/M/A(=
Uniform Gifts to Minors Act). 

  
 A-8 

 19.    Governing Law. The Base Indenture, the Supplemental
Indenture and this Security shall be deemed to be a contract made under the internal laws of the State of New York, and for all purposes shall be construed in accordance with the laws of said State. 

  
 A-9 

 ASSIGNMENT FORM 

To assign this Security, fill in the form below: (I) or (we) assign and transfer this Security to 

 
  

(Insert assignee’s soc. sec. or tax I.D. no.) 
  

 
  
  

 
  

 
  

 
 (Print or type assignee’s name,
address and zip code) 
 and irrevocably appoint
                                         
                                         
                   agent to transfer this Security on the books of the Company. The agent may substitute another to act for him. 

Date:                         
                
 Your
Signature                                       
                          

(Sign exactly as your name appears on the face of this Security) 

Signature
Guarantee:                                       
                          

  
 A-10 

 OPTION OF HOLDER TO ELECT PURCHASE 

If you want to elect to have this Security purchased by the Company pursuant to Section 1.4(l) of the Supplemental Indenture, check the
box: 
  

	☐	 1.4(l) Change of Control Triggering Event 

If you want to elect to have only part of this Security purchased by the Company pursuant to Section 1.4(l) of the Supplemental
Indenture, state the amount:
€                                        
 
  

			
	Date:                                     
   	  	 Your
Signature                                       
                         

(Sign exactly as your name appears on the face of this Security)

 Tax I.D.
Number:                                        
 
 Signature Guarantee:
                                         
                                         
       
 (Signature must be guaranteed by a 

participant in a recognized signature 

guarantee medallion program) 

  
 A-11

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