Document:

exv10w34

Exhibit 10.34

DIRECTOR COMPENSATION ARRANGEMENTS

     For the twelve month period ending June 30, 2011, each non-employee director of Cardiovascular
Systems, Inc. will receive the following compensation:

	 	•	 	Retainers of $40,000 for service as a board member; $20,000 for service as a chairman
of a board committee; $10,000 for service as a member of a board committee; and $1,200
per board or committee meeting attended in the event that more than 12 of such meetings
are held during the period. The Company may pay these retainers in cash or permit
directors to elect to receive the value of the retainers in the Company’s common stock.
	 
	 	•	 	A restricted stock unit award with a value of $100,000 payable, in the Company’s
discretion, in cash or in shares of the Company’s common stock. The Company may provide
for the restricted stock units, when paid in cash, to be made in a lump sum on the six
month anniversary of the termination of the director’s board membership.

     In addition, the Chairman of the Board receives an annual retainer of $40,000, which may, at
the election of the Chairman, be paid in shares of common stock based on the fair market value of
the Company’s common stock on the date of payment. The non-employee members of the Board are also
reimbursed for travel, lodging and other reasonable expenses incurred in attending board or
committee meetings.exv10w38

Exhibit 10.38

CARDIOVASCULAR SYSTEMS, INC.

SUMMARY OF

EXECUTIVE OFFICER SEVERANCE PLAN

     Effective June 28, 2010, the Company adopted the Cardiovascular Systems, Inc. Executive
Officer Severance Plan. The Severance Plan applies initially to: David L. Martin, President and
Chief Executive Officer; Laurence L. Betterley, Chief Financial Officer; James E. Flaherty, Chief
Administrative Officer and Secretary; Robert J. Thatcher, Executive Vice President; Brian Doughty,
Vice President of Commercial Operations; Paul A. Tyska, Vice President of Business Development;
Paul A. Koehn, Vice President of Manufacturing; and Scott W. Kraus, Vice President of Sales.
Under the Severance Plan, if the Company terminates an executive without cause or due to a
reduction in force, as defined in the plan, the executive will receive certain severance benefits
during the severance period. The severance period is 18 months for the Chief Executive Officer; 15
months for the Chief Financial Officer, and 12 months for all other executives. For purposes of the
Severance Plan, “cause” is generally defined as the executive’s (i) failure to perform his material
duties; (ii) willful or deliberate misconduct; (iii) false or materially misleading representation
made to the Board; or (iv) commission of any felony. “Reduction in force” is generally defined as
an action or decision involving the termination of employment of the Company’s employees that is
designated by the Compensation Committee, in its sole and absolute discretion, as a
“Reduction-in-Force.”

     The severance benefits generally consist of the continued payment of (i) the executive’s
then-current base salary; and (ii) the Company’s share of the costs of the executive’s coverage
under the Company’s medical, dental, and life insurance plans. As a condition to receiving these
severance benefits, the executive is required to execute a release of claims agreement in favor of
the Company. The executive is not entitled to severance benefits if his termination is due to
death or disability; if the executive is on military leave, sick leave, or another bona fide leave
of absence generally not exceeding six months; or if the executive continues to provide services to
the Company in excess of 20% of the average level of services he performed over the immediately
preceding 36-month period.

     The Severance Plan does not affect any other rights the Company’s executives may have to
severance benefits in their employment agreements. However, an executive will be eligible for
severance benefits under the Severance Plan only to the extent the severance is not duplicative of
the benefits received by the executive under his employment agreement. The executive will receive
benefits under his employment agreement first, and then will be eligible for severance benefits
under the Severance Plan; provided, however, that the combined benefit will not exceed the maximum
benefit available under the Severance Plan.

     Although the Company has the right to amend or terminate the Severance Plan, the Company may
not do so in any manner that diminishes the severance benefits (i) within 12 months of a change of
control (the sale by the Company of substantially all of its assets and the consequent
discontinuance of its business; a merger, exchange, liquidation or certain acquisitions; certain
changes in the composition of the Board; or a definitive agreement relating to any of these); (ii)
if such amendment or termination was requested by a party other than the Board, that had previously
taken other steps reasonably calculated to result in a change of control and that ultimately
resulted in a change of control; or (iii) if such amendment or termination arose in connection with
or in anticipation of a change of control that ultimately occurs.exv10w45

Exhibit 10.45

EMPLOYMENT AGREEMENT

This employment agreement is made and entered into as of this 6 day of July, 2010, by and between
Unilife Corporation (“Unilife”) and J. Christopher Naftzger (“Naftzger”). The term “Unilife” shall
include its subsidiaries, affiliates, assigns and successors in interest under Sections 7, 8, and
13.

WHEREAS, Unilife wishes to employ Naftzger as General Counsel, Corporate Secretary and Chief
Compliance Officer, and Naftzger wishes to enter into this agreement to formalize his employment
agreement; and

WHEREAS, Unilife is engaged in the business of designing, developing, manufacturing and supplying
innovative healthcare safety products for medical device and pharmaceutical industries; and

WHEREAS, Naftzger will develop valuable relationships by virtue of his employment with Unilife, and
Naftzger will have access to valuable confidential and proprietary information and trade secrets
belonging to Unilife; and

WHEREAS, Unilife and Naftzger desire to set forth the terms of their employment relationship in
this agreement;

NOW, THEREFORE, in consideration of the promises and covenants set forth herein, and intending to
be legally bound hereby, the parties agree as follows:

1. Term. This agreement shall be effective upon the counter-execution of this agreement
and is for an initial multi-year term commencing on the effective date and expiring on June 30,
2012. This agreement will automatically renew for one-year periods annually thereafter, unless
either party gives the other party thirty (30) days written notice in advance of the relevant
expiration date of its intention not to renew the agreement. Upon expiration or earlier
termination of this employment relationship, the parties will be relieved of their duties and
obligations under this agreement, except that the rights and obligations of Unilife under Section 6
below shall remain in full force and effect until all appropriate payments have been made to
Naftzger and the rights and obligations of Naftzger set forth in Sections 7 and 8 below shall
remain in full force and effect and shall survive the expiration or termination of this agreement,
regardless of the reason(s) for termination.

2. Position and Duties.

     (a) Unilife will employ Naftzger as General Counsel, Corporate Secretary, and Chief Compliance
Officer and Naftzger agrees to serve in such capacity for Unilife with responsibility for Unilife’s
Legal and Corporate Secretarial function and such other duties as are assigned to him by the Chief
Executive Officer of Unilife, and shall have vested in him the authority and duties typically held
by an employee in such position. Naftzger shall report to the Chief Executive Officer, with
respect to the performance of

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these duties, and shall be a member of the Executive Team. In the performance of these
duties, Naftzger shall devote his knowledge, skill, attention, energies and all of his business
time, and shall comply with all of Unilife’s policies, rules, and procedures, as they may be
amended from time to time. Naftzger shall not engage in any endeavor that would conflict with the
rendition of his services to Unilife, either directly or indirectly, without the prior written
consent of Unilife; provided, however, Naftzger may participate in civic, charitable, educational,
industry and professional organizations, to the extent that such participation does not interfere
with the performance of his duties hereunder; and Naftzger may also serve on corporate boards and
committees, but only with the prior written consent of Unilife.

     (b) Notwithstanding the responsibilities and duties contained in Section 2(a) above, Naftzger
acknowledges that all material decisions relating to the management of Unilife’s business will be
made by the Board of Directors of Unilife. In addition, any decisions which have the capacity to
affect significantly the financial standing of Unilife must be referred to the Board of Directors
of Unilife which will have ultimate control in respect of these matters.

3. Compensation.

     (a) Base Salary. Naftzger shall be paid an annual base salary of Two Hundred Thousand
Dollars ($200,000.00) payable in accordance with Unilife’s standard payroll practices. Naftzger’s
base salary will be subject to the customary withholding and employment taxes, as required by law,
with respect to compensation paid by an employer to an employee. At the discretion of the Board of
Directors of Unilife, Naftzger shall be eligible for increases in base salary. Further, Unilife
will not reduce Naftzger’s base salary to less than what is agreed to herein.

     (b) Bonus. Naftzger shall be eligible to participate in Unilife’s Incentive Bonus
Plan in amounts and percentages as annually determined by Unilife’s Board of Directors and Chief
Executive Officer. For calendar year 2010, the potential cash bonus amount will be thirty percent
(30%) of base salary, prorated based on the number of days employed in 2010. For calendar years
2011 and 2012, Naftzger’s annual target cash bonus shall be a minimum of thirty percent (30%) of
base salary. Bonuses are subject to achievement of such goals and objectives as the Compensation
Committee of the Board of Directors, upon recommendation of the Chief Executive Officer, determines
in a set of Key Performance Indicators. Any bonus payable for a calendar year shall be paid in a
lump-sum payment in the following calendar year on or before March 15. Naftzger’s bonuses will be
subject to the customary withholding and employment taxes, as required by law, with respect to
compensation paid by an employer to an employee.

4. Benefits.

     (a) Benefits Generally Available to Unilife Employees. Naftzger shall be eligible to
participate in Unilife’s benefits programs (including any equity incentive plan of Unilife or its
affiliates), as they may change from time to time. The benefits provided

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to Naftzger will be the same as the benefits provided to other similarly situated Unilife
employees, and may be changed upon expiration or other termination of the current benefits
contracts. For further information, Naftzger should review any applicable benefit plan documents,
which will govern the terms of the benefits. Notwithstanding the above, Unilife agrees to request
a waiver of the waiting period for health benefits for Naftzger and his spouse and will repay
Naftzger for any negative tax consequences of such waiver. Alternatively, Unilife will pay
Naftzger’s current COBRA payment until such time as he is eligible for benefits.

     (b) Vacation. Naftzger shall also receive four (4) weeks of paid vacation per
calendar year. Any unused vacation days may be carried over or paid in lieu thereof, to the extent
allowed by Unilife’s policy for similarly situated employees.

     (c) Equity Plans. All incentive compensation and stock-based compensation that
Naftzger may receive from Unilife shall be subject to any policy adopted by Unilife, now or
hereafter existing, that imposes on Naftzger stock ownership requirements, stock holding
requirements, stock liquidation restrictions or recoupment provisions provided that such
requirements, restrictions and recoupment provisions also apply to similarly situated members of
senior management. Any stock options and other stock-based awards that Naftzger may receive from
Unilife shall be governed by the applicable, underlying award agreement.

     (d) Expenses. Unilife shall reimburse Naftzger for all reasonable and necessary
expenses incurred by him in carrying out his duties under this Agreement in accordance with
Unilife’s business expense policies, including without limitation, requirements with
respect to reporting, documentation and payment of such expenses. All such expenses shall be paid
no later than December 31st of the calendar year following the year in which such
expenses were incurred.

5. Indemnification. Unilife agrees to provide Naftzger with indemnification equivalent to
that provided to other members of senior management and pursuant to Unilife’s Directors and
Officers insurance policies, as amended from time to time.

6. Termination and Pay upon Termination.

     (a) General Rule. In the event that Unilife terminates this agreement and Naftzger’s
employment without Cause as defined herein, including employment termination due to Unilife’s
election not to renew this agreement where Naftzger was willing and able to continue performing
services under the terms of this agreement, Unilife will pay Naftzger:

     (i) his base salary, at the rate in effect immediately before the date that Naftzger’s
employment terminates, for twelve (12) months, in accordance with Unilife’s standard payroll
practices then in effect, commencing on the fifteenth (15th) day after the date
that Naftzger’s employment terminates and the

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General Release provided for in Section 10 of this Agreement becomes irrevocable; and

     (ii) provided that Naftzger is eligible for and timely elects to receive COBRA health
care continuation coverage, the cost of Naftzger’s COBRA health care continuation coverage
premiums for twelve (12) months, commencing on the first of the month immediately after the
month which includes the date that Naftzger’s employment terminates and the General Release
provided for in Section 10 of this Agreement becomes irrevocable.

In the event that Naftzger terminates this agreement for any reason, including Naftzger’s election
not to renew the agreement, Naftzger shall not receive any compensation or benefits from the time
that he ceases to devote full time and attention to Unilife’s business, and, if Naftzger terminates
this agreement prior to June 30, 2012, Naftzger shall repay Unilife an amount equal to the
aggregate cost incurred by Unilife under Section 9 of this Agreement in connection with Naftzger’s
relocation to Pennsylvania, unless such termination is due to Naftzger’s death, total disability or
termination of employment under the terms of Section 6(b) of this Agreement in connection with a
Change in Control , as defined below. The obligation to repay the expense of relocation may be
waived by the Compensation Committee of the Board of Directors in its sole discretion. In
addition, Naftzger agrees to provide Unilife with thirty (30) days advance written notice of his
intent to terminate his employment, whether during the initial term or any renewal thereof. Upon
termination of this agreement, the parties will be relieved of their duties and obligations, except
that the rights and obligations of Unilife under this Section 6(a) shall remain in full force and
effect until all appropriate payments have been made to Naftzger and the rights and obligations of
Naftzger set forth in Sections 7 and 8 below shall remain in full force and effect and shall
survive the expiration or termination of this agreement, regardless of the reason(s) for
termination. Upon termination of this agreement, Naftzger shall not have any further contact with
any customers of Unilife until the expiration of the conditions of Section 8 of this Agreement.

     (b) Termination Following a Change in Control.

     (i) Termination Pay. Notwithstanding paragraph (a) immediately above, in the
event that Naftzger’s employment is terminated coincident with a Change in Control as
defined in subparagraph (iii) immediately below, then Unilife in lieu of and not in
duplication of the severance compensation provided for in paragraph (a) immediately above,
shall pay Naftzger:

     (A) his base salary, at the rate in effect immediately before the date that
Naftzger’s employment terminates, for eighteen (18) months, in accordance with
Unilife’s standard payroll practices then in effect, commencing on the fifteenth
(15th) day after the date that Naftzger’s employment terminates and the
General Release provided for in Section 10 of this Agreement becomes irrevocable,

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     (B) provided that Naftzger is eligible for and timely elects to receive COBRA
health care continuation coverage, the cost of Naftzger’s COBRA health care
continuation coverage premiums for eighteen (18) months, commencing on with the
first of the month immediately after the month which includes the date that
Naftzger’s employment terminates and the General Release provided for in Section 10
of this Agreement becomes irrevocable,

     (C) payment of a lump-sum amount, equal to the amount of the bonus, if any,
earned by and paid to Naftzger for the last completed fiscal year prior to the year
in which his employment terminates, which will be payable on the fifteenth
(15th) day after the date that Naftzger’s
employment terminates and the General Release provided for in Section
10 of this Agreement becomes irrevocable, and

     (D) notwithstanding anything to the contrary, all of his outstanding and
unvested options and other stock-based awards shall vest immediately upon such
termination of employment following the Change in Control.

Notwithstanding anything to the contrary, if the Change in Control trigger is a change in Alan
Shortall no longer being Chief Executive Officer of Unilife, Naftzger shall have the option to
voluntarily resign in the event of such a Change in Control, and receive the severance benefits set
forth in this Section 6(b)(i), however, Naftzger must exercise such resignation right in writing
within one hundred and eighty (180) days of such Change in Control event or, in the absence of such
written resignation, he shall be deemed to have acknowledged that no Change in Control has occurred
for purposes of this Section 6(b)(i).

     (ii) Definition of “Cause”. “Cause” will mean any one or more of the
following:

     (A) material neglect of assigned duties, willful misconduct in connection with
the performance of duties, or refusal to perform assigned duties (other than by
reason of disability) which continues uncured for thirty (30) days following receipt
of written notice of such deficiency from the Chief Executive Officer, specifying
the scope and nature of the deficiency;

     (B) an act of dishonesty;

     (C) engaging in illegal conduct or committing a crime;

     (D) being the subject of disciplinary action by any disciplinary body governing
attorneys, losing his license to practice law or otherwise

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becoming disqualified to
practice law or represent Unilife as counsel in Pennsylvania or any other
jurisdiction in which Naftzger is currently authorized to practice law or becomes
authorized to practice law while employed by Unilife;

     (E) engaging in any act of moral turpitude that causes material harm to Unilife
or its reputation;

     (F) breaching, in any material respect, the terms of any agreement with
Unilife; or

     (G) commencement of employment with any other employer while an employee of
Unilife without the prior written consent of the Chief Executive Officer.

Any determination of “Cause” as used herein will be made in good faith by the Chief
Executive Officer.

     (iii) Definition of “Change in Control”. “Change in Control” means a: (i)
Change in Ownership of Unilife Corporation, (ii) Change in Effective Control of Unilife
Corporation, (iii) Change in the Ownership of Assets of Unilife Corporation, all as
described herein and construed in accordance with section 409A of the Internal Revenue Code
of 1986, as amended (the “Code”), or (iv) a change in the Chief Executive Officer whereby
the position is no longer held by Alan Shortall.

     (A) A Change in Ownership of Unilife Corporation shall occur on the date that
any one Person acquires, or Persons Acting as a Group (or Group) acquire, ownership
of the capital stock of Unilife Corporation that, together with the stock held by
such Person or Group, constitutes more than fifty percent (50%) of the total fair
market value or total voting power of the capital stock of Unilife Corporation.
However, if any one Person is, or Persons Acting as a Group are, considered to own
more than fifty percent (50%) of the total fair market value or total voting power
of the capital stock of Unilife Corporation, the acquisition of additional stock by
the same Person or Persons Acting as a Group is not considered to cause a Change in
Ownership of Unilife Corporation or to cause a Change in Effective Control of
Unilife Corporation. An increase in the percentage of capital stock owned by any
one Person, or Persons Acting as a Group, as a result of a transaction in which
Unilife Corporation acquires its stock in exchange for property will be treated as
an acquisition of stock.

     (B) A Change in Effective Control of Unilife Corporation shall occur on the
date a majority of members of the Board of Directors of Unilife Corporation is
replaced during any twelve (12)-month period by directors whose appointment or
election is not endorsed by a majority of

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the members of the Board of Directors of
Unilife Corporation before the date of the appointment or election.

     (C) A Change in the Ownership of Assets of Unilife Corporation shall occur on
the date that any one Person acquires, or Persons Acting as a Group acquire (or has
or have acquired during the twelve (12)-month period ending on the date of the most
recent acquisition by such Person or Persons), assets (including tangible/real
property and intangible property (such as goodwill)) from Unilife Corporation the
total gross fair market value of which is more than fifty percent (50%) of the total
gross fair market value of all of the assets of Unilife Corporation immediately
before such acquisition or acquisitions. For this purpose, gross fair market value
means the value of the assets of Unilife Corporation, or the value of the assets
being disposed of, determined without regard to any liabilities
associated with such assets.

     (D) The following rules of construction apply in interpreting the definition of
Change in Control:

     (I) A Person means any individual, entity or group within the meaning
of Section 13(d) (3) or 14(d) (2) of the Securities Exchange Act of 1934, as
amended, other than employee benefit plans sponsored or maintained by
Unilife Corporation and by entities controlled by Unilife Corporation or an
underwriter of the capital stock of Unilife Corporation in a registered
public offering.

     (II) Persons will be considered to be Persons Acting as a Group if they
are owners of a corporation that enters into a merger, consolidation,
purchase or acquisition of stock, or similar business transaction with the
corporation. If a Person owns stock in both corporations that enter into a
merger, consolidation, purchase or acquisition of stock, or similar
transaction, such shareholder is considered to be acting as a Group with
other shareholders only with respect to the ownership in that corporation
before the transaction giving rise to the change and not with respect to the
ownership interest in the other corporation. Persons will not be considered
to be acting as a Group solely because they purchase assets of the same
corporation at the same time or purchase or own stock of the same
corporation at the same time, or as a result of the same public offering.

     (III) For purposes of this Section 6(b), fair market value shall be
determined in accordance with Code Section 409A.

     (IV) A Change in Control shall not include a transfer to a related
person as described in Code section 409A or a public offering of capital
stock of Unilife Corporation.

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     (E) For purposes of this Section 6(b), Code section 318(a) applies to determine
stock ownership. Stock underlying a vested option is considered owned by the
individual who holds the vested option (and the stock underlying an unvested option
is not considered owned by the individual who holds the unvested option). For
purposes of the preceding sentence, however, if a vested option is exercisable for
stock that is not substantially vested (as defined by Treasury Regulation §1.83-3(b)
and (j)), the stock underlying the option is not treated as owned by the individual
who holds the option.

7. Confidential Information.

     (a) Naftzger acknowledges that Unilife has a valuable property interest in all aspects of its
business relationships with its customers, clients, vendors and suppliers. In the course of
Naftzger’s work with Unilife, Naftzger will become aware of and familiar with secret and
confidential information of Unilife relating to its customers, clients, vendors and suppliers, and
its internal business operations. Secret and confidential information includes, but is not limited
to, Unilife’s business plans, customer lists, customer data, marketing plans, supplier and vendor
lists and cost information, software and computer programs, data processing systems and information
contained therein, financial statements, financial data, acquisition and divestiture plans, and any
other trade secrets or confidential or proprietary information, documents, reports, plans, or data,
of or about Unilife that is not already available to the public.

     (b) Naftzger agrees that he will not, without the written consent of Unilife, during the term
of this agreement or thereafter, disclose or make any use of secret and confidential information,
except as may be required in the performance of his duties under Section 2 of this agreement.
Naftzger agrees that, following the termination of his employment with Unilife for any reason, he
will never use secret and confidential information to compete with Unilife in any manner, and he
will never disclose any secret and confidential information to any other business or individual,
unless such secret or confidential information is: (i) publicly known through no breach of the
provisions of this Section 7 by either party, (ii) lawfully disclosed by a third party, or (iii)
disclosed pursuant to legal requirement or court order. In no event shall any disclosure made to
investment banking firms or private equity firms at the request of Unilife and as part of
Naftzger’s duties ever be considered a violation of this Section 7.

     (c) Upon termination of this agreement, Naftzger shall surrender to Unilife all records and
all paper and/or electronic copies made of those records that pertain to any aspect of the business
of Unilife, including all secret and confidential information.

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8. Agreement Not To Compete.

     (a) In consideration for continued employment by Unilife and the benefits of this agreement,
Naftzger agrees to be bound by the covenant not to compete as set forth in Section 8 of this
agreement below.

     (b) Naftzger agrees that during the term of this agreement and for a period of two (2) years
following the termination of this agreement for any reason, he will not, directly or indirectly:

     (i) render services to, become employed by, be engaged as a consultant by, own, or
have a financial or other interest in (either as an individual, partner, joint venture,
owner, manager, employee, partner, officer, director, independent contractor, or other
similar role) any business that is engaged in any business activity that is in competition
with the activities of Unilife, as of the date of the termination of this agreement.

     (ii) induce, offer, assist, encourage, or suggest that another business or enterprise
offer employment to or enter into a consulting arrangement with any individual who is
employed by Unilife, or induce, offer, assist, encourage, or suggest that any Unilife
employee terminate her or her employment with Unilife, or accept employment with any other
business or enterprise.

     (c) In the event that Naftzger commits any breach of Section 8(b) above, Naftzger acknowledges
that Unilife would suffer substantial and irreparable harm and damages. Accordingly, Naftzger
hereby agrees that in such event, Unilife shall be entitled to temporary and/or permanent
injunctive relief, without the necessity of proving damage, to enforce the provisions of this
Section, all without prejudice to any and all other remedies that Unilife may have at law or in
equity and that Unilife may elect or invoke. Naftzger agrees that if any of the provisions of this
Section are or become unenforceable, the remainder hereof shall nevertheless remain binding upon
him to the fullest extent possible, taking into consideration the purposes and spirit of this
agreement. Any invalid or unenforceable provision is to be reformed to the maximum time,
geographic and/or business limitations permitted by applicable laws, so as to be valid and
enforceable.

     (d) Naftzger expressly acknowledges and agrees that the restrictive covenants set forth in
Sections 7 and 8 above are absolutely necessary to protect the legitimate business interests of
Unilife, because he is employed in a position of trust and confidence and is provided with
extensive access to Unilife’s most confidential and proprietary trade secrets, and has significant
involvement in important business relationships, which constitute the goodwill of Unilife.
Naftzger further agrees and acknowledges that these restrictive covenants are reasonable, will not
restrict him from earning a livelihood following the termination of employment, and are intended by
the parties to be enforceable following termination of employment for any reason.

     (e) In the event that Unilife must bring legal action to enforce or seek a remedy for any
breach of the provisions of Sections 7 or 8 of this agreement and

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Naftzger is found by a court to
have breached any of these provisions, Naftzger agrees to reimburse Unilife for any and all
expenses, including attorneys’ fees and court costs, incurred by it in enforcing the terms of these
Sections of the agreement.

9. Relocation and Temporary Housing Expenses.

(a) Unilife shall pay Naftzger $75,000 (the “Relocation Payment”), to assist Naftzger in paying
Naftzger’s relocation expenses associated with his move to Pennsylvania in connection with his
employment by Unilife. The Relocation Payment will be paid in a lump sum to him on or before July
16, 2010. If Naftzger incurs actual, reasonable and customary relocation expenses during the first
year of his employment that exceed $75,000 (for items such as closing costs relating to the sale of
Naftzger’s current house, payment for moving Naftzger’s household goods to Pennsylvania, including
packing, unpacking, and insurance, storage of Naftzger’s household goods for a maximum of six
months while Naftzger and his family are in temporary housing, and the cost of moving
up to two vehicles) (“Excess Relocation Expenses”), he may provide the Chief Executive Officer with
documentation of such Excess Relocation Expenses, and the Chief Executive Officer may elect, in his
discretion, to reimburse Naftzger for all or part of such Excess Relocation Expenses. In addition
to the Relocation Payment and Excess Relocation Expenses, Unilife will reimburse Naftzger for the
reasonable cost of temporary housing in Pennsylvania for up to six months and will reimburse
Naftzger and for the reasonable expenses associated with two house-hunting trips by Naftzger and
his spouse. Reimbursement of such costs and expenses will be made upon the request of Naftzger,
subject to Naftzger’s providing reasonable documentation of the reimbursable costs and expenses.

(b) Any taxes payable with respect to the payments made by Unilife to Naftzger pursuant to this
Section 9, including without limitation the Relocation Payment, shall be the sole responsibility of
Naftzger, and Unilife will follow federal, state and local tax regulations with regard to the
reporting of such payments. Unilife shall withhold applicable federal, state and local taxes using
the percentage method for supplemental income (i.e., flat tax of 25% for federal income taxes and
the applicable flat rate for FICA, state and local taxes).

10. General Release. As a condition of receiving the severance compensation and benefits
described in Section 6, Unilife and Naftzger will execute a mutual general release of claims (which
is in a form acceptable to Unilife). Such general release would not include rights to previously
vested options or claims for any compensation earned (including, without limitation, accrued
vacation), or reimbursement of expenses incurred, through the date of termination. Such release
must be agreed to, executed and irrevocable no later than 30 days following Naftzger’s termination
date.

11. Dispute Resolution. Any controversy, claim or dispute involving the parties (or their
affiliated persons) directly or indirectly concerning this agreement shall be finally settled by
binding arbitration held in Harrisburg, Pennsylvania by one arbitrator (who is mutually

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acceptable to both parties as well as licensed to practice law in the Commonwealth of Pennsylvania) in
accordance with the rules of employment arbitration then followed by the American Arbitration
Association or any successor to the functions thereof. The arbitrator shall apply Pennsylvania law
in the resolution of all controversies, claims and disputes and shall have the right and authority
to determine how his or her decision or determination as to each issue or matter in dispute may be
implemented or enforced. Any decision or award of the arbitrator shall be final and conclusive for
both Naftzger and Unilife (and its affiliates), and there shall be no appeal there from other than
causes of appeal allowed by the Federal Arbitration Act. Unilife shall bear all costs of the
arbitrator in any action brought under this agreement. The arbitrator shall have the power to
award attorney’s fees and arbitration costs to the prevailing party, if the award of attorney’s
fees and litigation costs would be permitted by a court. The parties hereto agree that any action
to compel arbitration may be brought in the appropriate Pennsylvania state or federal court, and in
connection with such action to compel, the laws of the Commonwealth of Pennsylvania and the Federal
Arbitration Act shall
control. Application may also be made to such court for confirmation of any decision or award of
the arbitrator, for an order of the enforcement and for any other remedies, which may be necessary
to effectuate such decision or award. The parties hereto hereby consent to the jurisdiction of the
arbitrator and of such court and waive any objection to the jurisdiction of such arbitrator and
court.

12. Non-waiver. A waiver of any provision of this agreement by either party shall not
prevent either party from enforcing that provision or any other provision hereof.

13. Assignment. This agreement is personal and may not be assigned by Naftzger. Any
assignment of this agreement between Unilife (or its successor) and its affiliates (and their
successors) shall not constitute a termination of Naftzger’s employment hereunder. This agreement
(including the Restrictive Covenants set forth in Sections 7 and 8) shall inure to the benefit of
and be binding upon any successor to Unilife. The parties specifically understand and agree that
the non-compete provisions of Section 8 will inure to the benefit of a successor and that Naftzger
will remain bound by these provisions in the event of a sale or corporate reorganization of
Unilife.

14. Severability. Each provision of this agreement is severable and distinct from, and
independent of, every other provision hereof. If one provision hereof is declared void, the
remaining provisions shall remain in effect. Any provision of this agreement which is prohibited
or unenforceable in any jurisdiction shall, as to such jurisdiction, be ineffective only to the
extent of such prohibition or unenforceability without invalidating or affecting the remaining
provisions hereof, and any such prohibition or unenforceability in any jurisdiction shall not
invalidate or render unenforceable such provision in any other jurisdiction.

15. Entire Agreement. This agreement contains the entire agreement of the parties
concerning the employment relationship and supersedes any prior agreements or understandings
between the parties concerning the terms and conditions of Naftzger’s employment, whether oral or
written; provided, however, that Naftzger’s equity grants

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shall be governed by the equity grant
documents; provided further, that any stock options or other stock-based awards provided to
Naftzger shall be governed by Unilife’s stock incentive plans as they are amended from time to
time, except as provided herein. The parties acknowledge, in entering into this agreement that
they have not relied upon any promise or inducement not specifically set forth herein. Any changes
to this agreement must be in writing and signed by both parties.

16. Section 409A.

     (a) This agreement is intended to comply with, or otherwise be exempt from, Code section 409A
and any regulations and Treasury guidance promulgated thereunder, and Unilife shall be required to
interpret the terms of this agreement as necessary to comply with the requirements of Code section
409A.

     (b) Unilife shall undertake to administer, interpret, and construe this agreement in a manner
that does not result in the imposition on Naftzger of any additional tax, penalty, or interest
under Code section 409A.

     (c) Unilife and Naftzger agree that they will execute any and all amendments to this agreement
permitted under applicable law as they mutually agree in good faith may be necessary to ensure
compliance with the distribution provisions of Code section 409A or as otherwise needed to ensure
that this agreement complies with that section.

     (d) The preceding provisions, however, shall not be construed as a guarantee by Unilife of any
particular tax effect to Naftzger under this agreement. Unilife shall not be liable to Naftzger
for any payment made under this agreement that is determined to result in an additional tax,
penalty, or interest under Code section 409A, nor for reporting in good faith any payment made
under this agreement as an amount includible in gross income under that section.

     (e) For purposes of Code section 409A, the right to a series of installment payments under
this agreement shall be treated as a right to a series of separate payments.

     (f) With respect to any reimbursement of future expenses of, or any provision of in-kind
benefits to, Naftzger, as specified under this agreement, such reimbursement of expenses or
provision of in-kind benefits shall be subject to the following conditions: (i) the expenses
eligible for reimbursement or the amount of in-kind benefits provided in one taxable year shall not
affect the expenses eligible for reimbursement or the amount of in-kind benefits provided in any
other taxable year, except for any medical reimbursement arrangement providing for the
reimbursement of expenses referred to in Code section 105(b); (ii) the reimbursement of an eligible
expense shall be made no later than the end of the year after the year in which such expense was
incurred; and (iii) the right to reimbursement or in-kind benefits shall not be subject to
liquidation or

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exchange for another benefit. Any tax gross-up payment shall be made by no later
than the end of the calendar year following the year in which Naftzger remits the taxes.

     (g) “Termination of employment,” “resignation,” or words of similar import, as used in this
agreement means, for purposes of any payments under this agreement that are payments of deferred
compensation subject to Code section 409A, Naftzger’s “separation from service” as defined in that
section.

     (h) If a payment obligation under this agreement arises on account of Naftzger’s separation
from service while Naftzger is a “specified employee” (as defined under Code section 409A and
determined in good faith by the Unilife), any payment of “deferred compensation” (as defined under
Treasury regulation section 1.409A-1(b)(1), after giving effect to the exemptions in Treasury
regulation sections 1.409A-1(b)(3) through (b)(12)) that is scheduled to be paid within six (6)
months after such separation from service shall accrue without interest and shall be paid within 15
days after the end of the six-month period beginning on the date of such separation from service
or, if
earlier, within 15 days after the appointment of the personal representative or executor of
Naftzger’s estate following his death.

17. Excise Tax on Parachute Payments. Naftzger shall bear all expense of, and be
solely responsible for, all federal, state, local or foreign taxes due with respect to any payment
received hereunder, including, without limitation, any excise tax imposed by Code section 4999;
provided, however, that any payment or benefit received or to be received by Naftzger in connection
with a Change in Control or the termination of Naftzger’s employment (whether payable pursuant to
the terms of this Agreement (“Contract Payments”) or any other plan, arrangements or agreement with
Unilife or any affiliate (collectively with the Contract Payments, the “Total Payments”) shall be
reduced to the extent necessary so that no portion thereof shall be subject to the excise tax
imposed by Code section 4999 but only if, by reason of such reduction, the net after-tax benefit
received by Naftzger shall exceed the net after-tax benefit that would be received by Naftzger if
no such reduction was made.

     For purposes of this Section 17, “net after-tax benefit” shall mean (i) the total of all
payments and the value of all benefits which Naftzger receives or is then entitled to receive from
Unilife that would constitute “excess parachute payments” within the meaning of Code section 280G,
less (ii) the amount of all federal, state, local and foreign income taxes payable with respect to
the foregoing calculated at the maximum marginal income tax rate for each year in which the
foregoing shall be paid to Naftzger (based on the rate in effect for such year as set forth in the
Code or other applicable tax law as in effect at the time of the first payment of the foregoing),
less (iii) the amount of excise taxes imposed with respect to the payments and benefits described
in (i) above by Code section 4999.

     The foregoing determination shall be made by a nationally recognized accounting firm (the
“Accounting Firm”) selected by Unilife and reasonably acceptable to Naftzger (which may be, but
will not be required to be, Unilife’s independent auditors). The

Page 13 of 15

 

Accounting Firm shall submit its
determination and detailed supporting calculations to both Naftzger and Unilife within fifteen (15)
days after receipt of a notice from either Unilife or Naftzger that Naftzger may receive payments
which may be “parachute payments.” If the Accounting Firm determines that a reduction is required
by this Section 17, the Contract Payments consisting of cash severance shall be reduced to the
extent necessary so that no portion of the Total Payments shall be subject to the excise tax
imposed by Code section 4999, and Unilife shall pay such reduced amount to Naftzger in accordance
with the terms of this agreement. If the Accounting Firm determines that none of the Total
Payments, after taking into account any reduction required by this Section 17, constitutes a
“parachute payment” within the meaning of Code section 280G, it will, at the same time as it makes
such determination, furnish Naftzger and Unilife an opinion that Naftzger has substantial authority
not to report any excise tax under Code section 4999 on his federal income tax return.

     Naftzger and Unilife shall each provide the Accounting Firm access to and copies of any books,
records, and documents in the possession of Naftzger or Unilife, as the
case may be, reasonably requested by the Accounting Firm, and otherwise cooperate with the
Accounting Firm in connection with the preparation and issuance of the determinations and
calculations contemplated by this Section 17. The fees and expenses of the Accounting Firm for its
services in connection with the determinations and calculations contemplated by this Section 17
shall be borne by Unilife.

18. Counterparts. This agreement may be executed on separate counterparts, each of which
is deemed to be an original and all of which taken together constitute one and the same agreement.

19. Interpretation. The captions and headings of this agreement are not part of the
provisions hereof and shall have no force or effect.

20. Notices. Any notices, requests, demands and other communications provided for by this
agreement shall be sufficient if in writing and if hand delivered, sent by overnight courier, or
sent by registered or certified mail to Naftzger at the last address he has filed in writing with
Unilife or, in the case of Unilife, to Unilife’s Chief Executive Officer at Unilife’s principal
executive offices.

21. Governing Law. The terms of this agreement shall be governed by and construed in
accordance with the laws of the Commonwealth of Pennsylvania without giving effect to provisions
thereof regarding conflict of laws.

22. Continuing Legal Education and Bar Membership Reimbursement. Unilife agrees to
reimburse Naftzger for all the costs associated with maintaining his license to practice law,
including but not limited to licensing fees, bar membership fees, the cost of continuing legal
education (and time off with pay to attend such seminars).

23. Naftzger represents and warrants to Unilife that he is not bound by any restrictive covenants
and has no prior or other obligations or commitments of any kind that

Page 14 of 15

 

would in any way
prevent, restrict, hinder or interfere with Naftzger’s acceptance of employment or the
performance of all duties and services hereunder to the fullest extent of Naftzger’s ability
and knowledge.

     IN WITNESS WHEREOF, and wishing to be legally bound, the parties have executed this agreement
as of the date first above written.

	 	 	 	 	 

	UNILIFE CORPORATION:	 	J. Christopher Naftzger:
	 
	 	 	 	 
	By:

	 	/s/ Alan Shortall
	 	/s/ J. Christopher Naftzger
	 

	 	 
	 	 
	 

	 	Name: Alan Shortall	 	 
	 

	 	Title: Chief Executive Officer	 	 

Page 15 of 15

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