Document:

March 4, 2008 Press Release

 Exhibit 10.1 
 Press 
 Release 
 Source: 
 Senetek PLC 
 Senetek PLC in Dispute with Marketer of Pyratine-6TM 
 Investor Update Conference Call Set for March 7 
 NAPA, Calif., March 4, 2008/ PRNewswire-First Call/
— Senetek PLC (OTCBB: SNKTY), a Life Sciences company engaged in the development of technologies that target the science of healthy aging , today announced it has entered into a contractual dispute resolution process with Triax Aesthetics
LLC, the privately-held specialty pharmaceuticals marketer which Senetek licensed in August 2007 to sell a line of skincare products featuring Senetek’s new Pyratine-6TM active ingredient to dermatologists and other physicians who prescribe
or dispense products and to chain drug stores for sale at the pharmacist’s counter. 
 Senetek also announced that it will conduct a teleconference for
investors on Friday, March 7, 2008 at 9:00 a.m. Pacific time, 12:00 p.m. Eastern time, at which Senetek management will give an update on the business including the appointment of two veteran sales and marketing executives and a Vice President
of Communications. The domestic dial-in number will be 877-593-8638 and the international dial-in number will be 706-634-9240, conference ID 37979186. Replay of the conference call will be available until March 14, 2008, domestic replay dial-in
800-642-1687, international replay dial-in 706-645-9291, replay conference ID 37979186. 
 *
    *     *     * 
 About Senetek PLC 
 Senetek PLC (OTCBB: SNKTY) is a Life Sciences company engaged in the development of breakthrough technologies that target the science of healthy aging. The Company’s
extensive research collaborations have resulted in a strong pipeline of patented compounds and products with broad therapeutic applications and a leading presence in dermatology. Senetek collaborates with established specialty pharmaceutical
companies in the final development and marketing of its proprietary products, most recently resulting in the development of the best-selling anti-aging product sold in the North American physician market. For more information, visit the
company’s website at http://www.senetekplc.com. 
 This news release contains statements that may be considered ‘forward-looking
statements’ within the meaning of the Private Securities Litigation Reform Act. Forward-looking statements by their nature involve substantial uncertainty, and actual results may differ materially from those that might be suggested by such
statements. Important factors identified by the Company that it believes could result in such material differences are described in the Company’s Annual Report on Form 10-K for the year 2006. However, the Company necessarily can give no 

 
assurance that it has identified or will identify all of the factors that may result in any particular forward-looking statement materially differing from
actual results, and the Company assumes no obligation to correct or update any forward-looking statements which may prove to be inaccurate, whether as a result of new information, future events or otherwise. 
 Company contact: 
 Marjorie Hays 
 Vice President, Communications 
 Senetek, PLC 
 1-707-226-3900 ext. 102Exhibit 4.1

 Exhibit 4.1 
 CAPITAL ONE MASTER TRUST 
 FIRST AMENDMENT TO AMENDED AND 
 RESTATED RECEIVABLES PURCHASE AGREEMENT 
 This
FIRST AMENDMENT TO AMENDED AND RESTATED RECEIVABLES PURCHASE AGREEMENT, dated as of March 1, 2008 (the “Amendment”) to the Amended and Restated Receivables Purchase Agreement, dated as of August 1, 2002, as amended and
restated as of July 1, 2007 and as supplemented to March 1, 2008 (the “Agreement”), is entered into between CAPITAL ONE BANK (USA), NATIONAL ASSOCIATION, a national banking association (the “Bank”), and
CAPITAL ONE FUNDING, LLC, a Virginia limited liability company (“Funding”). 
 WHEREAS, effective March 1, 2008,
Capital One Bank, a Virginia banking corporation (“Capital One Bank”), has been converted into and has become the Bank; 
 WHEREAS, by operation of law on March 1, 2008, all of the assets and rights of Capital One Bank have become vested in the Bank, and the Bank has assumed all of the liabilities and obligations of Capital One Bank; 
 NOW, THEREFORE, in consideration of the premises and agreements contained herein and notwithstanding anything to the contrary set forth in the Agreement,
the undersigned parties hereby agree as follows: 
 ARTICLE I 
 AMENDMENTS 
 Section 1.01. Amendments to the Agreement. The Agreement is hereby amended as
follows: 
 (a) by deleting all references therein to “Capital One Bank” and replacing such references with “Capital One Bank
(USA), National Association”; 
 (b) by deleting from the first paragraph of the Agreement and the Form of Supplemental Conveyance the
phrase “Virginia banking corporation” and replacing it with “national banking association”; 
 (c) by deleting in
Section 4.01(a)(i) the phrase “Virginia banking corporation validly existing under the laws of the Commonwealth of Virginia” and replacing it with “national banking association validly existing under the laws of the United
States”; 

 (d) by deleting in Section 4.01(a)(ii) the phrase “or foreign limited liability company”
and replacing it with “or other foreign entity (or is exempt from such requirements)”; and 
 (e) by deleting in Section 9.03
the phrase “8000 Jones Branch Drive, McLean, Virginia 22102, Attention: General Counsel (facsimile: (703) 875-1589)” and replacing it with, “4851 Cox Road, Glen Allen, Virginia 23060, Attention: General Counsel, with a copy to
Vice President Securitization (facsimile: (804) 967-1220).” 
 ARTICLE II 
 ASSIGNMENT AND ASSUMPTION 
 Section 2.01. Assignment and Assumption of the
Agreement. The Bank hereby confirms that it is bound by the Agreement, that it has assumed the performance of every liability and obligation of Capital One Bank under the Agreement and that all of Capital One Bank’s right, title and
interest in, to and under the Agreement has been vested in the Bank by operation of law. The Bank also ratifies, confirms, and effects the sales and other conveyances described in the Agreement and in each Supplemental Conveyance. For the avoidance
of doubt, the Bank hereby expressly assumes the performance of every covenant and obligation of the Servicer under the Agreement. 
 ARTICLE
III 
 CONDITIONS PRECEDENT 
 Section 3.01. Effectiveness. The amendments and assignments provided for by this Amendment shall become effective upon satisfaction of the following conditions: 
 (a) delivery of an Opinion of Counsel, to Funding from the Bank, to the effect that all actions have been taken, and all filings have been made, as are
necessary to continue and maintain the first-priority perfected ownership interest of Funding in the Purchased Assets delivered pursuant to Subsection 5.01(k) of the Agreement; 
 (b) ten (10) days prior notice from the Bank to Funding, the Trustee and each Rating Agency of this Amendment delivered pursuant to Sections 9.01
and 9.05 of the Agreement; 
 (c) delivery of written confirmation to Funding and the Trustee from each Rating Agency that this Amendment
will not result in the reduction or withdrawal of the respective ratings of such Rating Agency for any securities issued by the Trust delivered pursuant to Sections 9.01 and 9.05 of the Agreement; 

 (d) delivery of an Officer’s Certificate, from the Bank to Funding, stating that the Bank reasonably
believes that such action will not cause a Pay Out Event delivered pursuant to Section 9.01 of the Agreement; 
 (e) a copy of this
Amendment shall be sent to each Rating Agency; 
 (f) counterparts of this Amendment, duly executed by the parties hereto; and 
 (g) Capital One Bank has been converted into and has become the Bank. 
 ARTICLE IV 
 MISCELLANEOUS 
 Section 4.01. Waiver of Notice. Notwithstanding anything to the contrary set forth in the Agreement, each of the undersigned parties hereby waive any notice or other timing requirements with respect to and
gives its consent to the amendments and assignments provided for herein. 
 Section 4.02. Ratification of Agreement. Except as
specifically amended, modified or supplemented by this Amendment, the Agreement is hereby confirmed and ratified in all respects and shall remain in full force and effect. This Amendment shall not constitute a novation of the Agreement, but shall
constitute an amendment and assignment thereof. Each of the parties to the Agreement agrees to be bound by the terms of the obligations of the Agreement, as amended and assigned by this Amendment, as though the terms and obligations of such
agreement were set forth herein. 
 Section 4.03. Counterparts. This Amendment may be executed in any number of counterparts and
by separate parties hereto on separate counterparts, each of which when executed shall be deemed an original, but all such counterparts taken together shall constitute one and the same instrument. 
 Section 4.04. Governing Law. THIS AMENDMENT SHALL BE CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK, WITHOUT REFERENCE TO ITS
CONFLICT OF LAW PROVISIONS (OTHER THAN SECTION 5-1401 OF THE GENERAL OBLIGATIONS LAW), AND THE OBLIGATIONS, RIGHTS, REMEDIES OF THE PARTIES HEREUNDER SHALL BE DETERMINED IN ACCORDANCE WITH SUCH LAWS. 
 Section 4.05. Defined Terms and Section References. Capitalized terms used herein and not otherwise defined herein shall have the meanings
given to such terms in the Agreement. All Section or Subsection references herein shall mean Sections or Subsections in the Agreement, except as otherwise provided herein. 

 IN WITNESS WHEREOF, the undersigned parties have caused this Amendment to be duly executed by their
respective officers thereunto duly authorized, all as of the date first above written. 
  

			
	CAPITAL ONE BANK (USA), NATIONAL
ASSOCIATION
		
	By:	 	 /s/ Richard Johns

	Name:	 	Richard Johns
	Title:	 	Vice President, Treasury
	
	CAPITAL ONE FUNDING, LLC
		
	By:	 	 /s/ Robert Stradtman

	Name:	 	Robert Stradtman
	Title:	 	Assistant Vice President

 Acknowledged and Accepted by: 
  

			
	THE BANK OF NEW YORK, as Trustee
		
	By:	 	 /s/ Catherine M. Hughes

	Name:	 	Catherine M. Hughes
	Title:	 	Assistant Vice President

 [Signature Page to First Amendment to COMT Receivables Purchase Agreement]

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