Document:

Loan and Security Agreement dated December 22, 2010

 Exhibit 10.1 
 LOAN AND SECURITY AGREEMENT 
 THIS LOAN AND SECURITY
AGREEMENT (this “Agreement”) dated as of December 22, 2010 (the “Effective Date”) among OXFORD FINANCE CORPORATION, a Delaware corporation with an office located at 133 North Fairfax Street,
Alexandria, Virginia 22314 (“Oxford”), as collateral agent (in such capacity, the “Collateral Agent”), the Lenders listed on Schedule 1.1 hereof or otherwise a party hereto from time to time including Oxford in its
capacity as a Lender (each a “Lender” and collectively, the “Lenders”), ZALICUS INC., a Delaware corporation with offices located at 245 First Street, Third Floor, Cambridge, Massachusetts 02142
(“Zalicus”) and ZALICUS PHARMACEUTICALS LTD., a corporation organized under the laws of British Columbia, Canada (“Zalicus-Canada”) (Zalicus and Zalicus-Canada are referred to herein individually and
collectively, jointly and severally, solidarily, as “Borrower”), provides the terms on which the Lenders shall lend to Borrower and Borrower shall repay the Lenders. The parties agree as follows: 

 

	 	 1
	 ACCOUNTING AND OTHER TERMS 

 1.1         Accounting terms not defined in this Agreement shall be construed in accordance with GAAP. Calculations and determinations must be made in
accordance with GAAP. Capitalized terms not otherwise defined in this Agreement shall have the meanings set forth in Section 14. All other terms contained in this Agreement, unless otherwise indicated, shall have the meaning provided by the
Code to the extent such terms are defined therein. All references to “Dollars” or “$” are United States Dollars, unless otherwise noted. 
  

	 	 2
	 LOANS AND TERMS OF PAYMENT 

 2.1         Promise to Pay Borrower hereby unconditionally promises to pay each Lender, the outstanding principal amount of all Term Loans advanced to
Borrower by such Lender and accrued and unpaid interest thereon and any other amounts due hereunder as and when due in accordance with this Agreement. 
  

	 	 2.2
	 Term Loans. 

 (a)         Availability.     (i) Subject to the terms and conditions of this Agreement, the Lenders agree, severally and not
jointly, to make term loans to Borrower on the Effective Date in an aggregate amount up to Three Million Dollars ($3,000,000) according to each Lender’s Term A Loan Commitment as set forth on Schedule 1.1 hereto (such term loans are
hereinafter referred to singly as a “Term A Loan”, and collectively as the “Term A Loans”). After repayment, no Term A Loan may be re-borrowed. 

(ii) Subject to the terms and conditions of this Agreement, the Lenders agree, severally and not jointly, during the
Second Draw Period, to make term loans to Borrower in an aggregate amount up to Eight Million Five Hundred Thousand Dollars ($8,500,000) according to each Lender’s Term B Loan Commitment as set forth on Schedule 1.1 hereto (such term
loans are hereinafter referred to singly as a “Term B Loan”, and collectively as the “Term B Loans”). After repayment, no Term B Loan may be re-borrowed. 

(iii) Subject to the terms and conditions of this Agreement, the Lenders agree, severally and not jointly, during the
Third Draw Period, to make term loans to Borrower in an aggregate amount up to Eight Million Five Hundred Thousand Dollars ($8,500,000) according to each Lender’s Term C Loan Commitment as set forth on Schedule 1.1 hereto (such term
loans are hereinafter referred to singly as a “Term C Loan”, and collectively as the “Term C Loans”; each Term A Loan, Term B Loan or Term C Loan is hereinafter referred to singly as a “Term Loan”
and the Term A Loans, the Term B Loans and the Term C Loans are hereinafter referred to collectively as the “Term Loans”). After repayment, no Term C Loan may be re-borrowed. 

(b)         Repayment.
    (i) Borrower shall make monthly payments of interest only commencing on the first
(1st) Payment Date following the Funding Date of the
Term A Loans, and continuing on the Payment Date of each successive month thereafter through and including the Payment Date immediately preceding the Amortization Date. Commencing on the Amortization Date, and continuing on the Payment Date of each
month thereafter, Borrower shall make consecutive equal monthly payments of principal and interest, in arrears, to each Lender, as calculated by Collateral Agent based upon: (1) the amount of such Lender’s Term A Loan, (2) the
effective rate of interest, as determined in Section 2.3(a), and (3) a repayment schedule equal to thirty-six (36) months. All unpaid principal and accrued and unpaid interest with respect to the Term A Loans is due and payable in
full on the Maturity Date. The Term A Loans may only be prepaid in accordance with Sections 2.2(c) and 2.2(d). 

 (ii) Borrower shall make monthly payments of interest
only commencing on the first (1st) Payment Date
following the Funding Date of the Term B Loans, and continuing on the Payment Date of each successive month thereafter through and including the Payment Date immediately preceding the Amortization Date. Commencing on the Amortization Date, and
continuing on the Payment Date of each month thereafter, Borrower shall make consecutive equal monthly payments of principal and interest, in arrears, to each Lender, as calculated by Collateral Agent based upon: (1) the amount of such
Lender’s Term B Loan, (2) the effective rate of interest, as determined in Section 2.3(a), and (3) a repayment schedule equal to thirty-six (36) months. All unpaid principal and accrued interest with respect to the Term B
Loans is due and payable in full on the Maturity Date. The Term B Loans may only be prepaid in accordance with Sections 2.2(c) and 2.2(d). 
 (iii) Borrower shall make monthly payments of interest only commencing on the first (1st) Payment Date following the Funding Date of the Term C Loans, and continuing on the Payment Date of each
successive month thereafter through and including the Payment Date immediately preceding the Amortization Date. Commencing on the Amortization Date, and continuing on the Payment Date of each month thereafter, Borrower shall make consecutive equal
monthly payments of principal and interest, in arrears, to each Lender, as calculated by Collateral Agent based upon: (1) the amount of such Lender’s Term C Loan, (2) the effective rate of interest, as determined in
Section 2.3(a), and (3) a repayment schedule equal to thirty-six (36) months. All unpaid principal and accrued interest with respect to the Term C Loans is due and payable in full on the Maturity Date. The Term C Loans may only be
prepaid in accordance with Sections 2.2(c) and 2.2(d). 
 (c)
        Mandatory Prepayments.     If the Term Loans are accelerated pursuant to Section 9.1(a) hereof following the occurrence of an Event of Default, Borrower shall
immediately pay to Lenders, payable to each Lender in accordance with its respective Pro Rata Share, an amount equal to the sum of: (i) all outstanding principal of the Term Loans plus accrued interest thereon through the prepayment date,
(ii) the Final Payment, (iii) the Prepayment Fee, plus (iv) all other sums, that shall have become due and payable under the Loan Documents, including Lenders’ Expenses and interest at the Default Rate with respect to any past
due amounts. Notwithstanding (but without duplication with) the foregoing, on the Maturity Date, if the Final Payment had not previously been paid in full in connection with the prepayment of the Term Loans in full, Borrower shall pay to Collateral
Agent, for payment to each Lender in accordance with its respective Pro Rata Share, the Final Payment in respect of the Term Loan(s). 
 (d)         Permitted Prepayment of Term Loans.     Borrower shall have the option to prepay all, but not less than all, of the Term A
Loans and/or the Term B Loans and/or the Term C Loans advanced by the Lenders under this Agreement, provided Borrower (i) provides written notice to Collateral Agent of its election to prepay the applicable Term Loans at least five
(5) Business Days prior to such prepayment, identifying whether Borrower will be prepaying all of the Term A Loans and/or all of the Term B Loans and/or all of the Term C Loans, and (ii) pays to the Lenders on the date of such prepayment,
payable to each Lender in accordance with its respective Pro Rata Share, an amount equal to the sum of (A) all outstanding principal of the Term Loans being prepaid plus accrued interest thereon through the prepayment date, (B) the Final
Payment in respect of the Term Loans being prepaid, (C) the Prepayment Fee in respect of the Term Loans being prepaid, plus (D) all other sums, that shall have become due and payable, including Lenders’ Expenses, if any, and interest
at the Default Rate with respect to any past due amounts. 

  
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	 	 2.3
	 Payment of Interest on the Credit Extensions. 

(a)         Interest Rate.     Subject to
Section 2.3(b), the principal amount outstanding under the Term Loans shall accrue interest at a fixed per annum rate (which rate shall be fixed for the duration of the applicable Term Loan) equal to the Basic Rate, determined by Collateral
Agent on the Funding Date of the applicable Term Loan, which interest shall be payable monthly in accordance with Sections 2.2(b) and 2.3(e). Interest shall accrue on each Term Loan commencing on, and including, the day on which the Term Loan is
made, and shall accrue on a Term Loan, or any portion thereof, for the day on which the Term Loan or such portion is paid. 
 (b)         Default Rate.     Immediately upon the occurrence and during the continuance of an Event of Default, Obligations shall bear
interest at a rate per annum which is five percentage points (5.00%) above the rate that is otherwise applicable thereto (the “Default Rate”). Payment or acceptance of the increased interest rate provided in this
Section 2.3(b) is not a permitted alternative to timely payment and shall not constitute a waiver of any Event of Default or otherwise prejudice or limit any rights or remedies of Collateral Agent. 

(c)         360-Day Year.     Interest shall be
computed on the basis of a 360-day year consisting of twelve (12) months of thirty (30) days. 
 (d)
        Debit of Accounts.     Collateral Agent and each Lender may debit the Designated Deposit Account, for (i) principal and interest payments when due, and (ii) any
other amounts Borrower owes the Lenders under the Loan Documents when due, provided that any debit pursuant to this clause (ii) shall only be made upon prior notice to Borrower. These debits shall not constitute a set-off. 

(e)         Payments.     Except as otherwise
expressly provided herein, all loan payments by Borrower hereunder shall be made to the respective Lender to which such payments are owed, at such Lender’s office in immediately available funds on the date specified herein. Unless otherwise
provided, interest is payable monthly on the Payment Date of each month. Payments of principal and/or interest received after 12:00 noon Eastern time are considered received at the opening of business on the next Business Day. When a payment is due
on a day that is not a Business Day, the payment is due the next Business Day and additional fees or interest, as applicable, shall continue to accrue until paid. All payments to be made by Borrower hereunder or under any other Loan Document,
including payments of principal and interest made hereunder and pursuant to any other Loan Document, and all fees, expenses, indemnities and reimbursements, shall be made without set-off, recoupment or counterclaim, in lawful money of the United
States and in immediately available funds. 
 2.4
        Secured Promissory Notes. Each Term Loan shall be evidenced by a Secured Promissory Note in the form attached as Exhibit D hereto (each a “Secured Promissory
Note”), and shall be repayable as set forth herein. Borrower irrevocably authorizes each Lender to make or cause to be made, on or about the Funding Date of any Term Loan or at the time of receipt of any payment of principal on such
Lender’s Secured Promissory Note, an appropriate notation on such Lender’s Secured Promissory Note Record reflecting the making of such Term Loan or (as the case may be) the receipt of such payment. The outstanding amount of each Term Loan
set forth on such Lender’s Secured Promissory Note Record shall be prima facie evidence of the principal amount thereof owing and unpaid to such Lender, but the failure to record, or any error in so recording, any such amount on such
Lender’s Secured Promissory Note Record shall not limit or otherwise affect the obligations of Borrower hereunder or under any Secured Promissory Note to make payments of principal of or interest on any Secured Promissory Note when due. Upon
receipt of an affidavit (including customary lost note indemnification provisions) of an officer of a Lender as to the loss, theft, destruction, or mutilation of its Secured Promissory Note, Borrower shall issue, in lieu thereof, a replacement
Secured Promissory Note in the same principal amount thereof and of like tenor. 
 2.5
        Fees. Borrower shall pay to Collateral Agent: 
 (a)
        Facility Fee.     A fully earned, non-refundable facility fee of One Hundred Thousand Dollars ($100,000) to be shared between the Lenders pursuant to their respective
Commitment Percentages, which fee was received by the Lenders prior to the Effective Date; 

  
 3 

 (b)         Final Payment.
    The Final Payment, when due hereunder, to be shared between the Lenders in accordance with their respective Pro Rata Shares; 
 (c)         Prepayment Fee.     The Prepayment Fee, when due hereunder, to be shared between the Lenders in accordance with their
respective Pro Rata Shares; and 
 (d)         Lenders’
Expenses.     All Lenders’ Expenses (including reasonable documented attorneys’ fees and expenses for documentation and negotiation of this Agreement) incurred through and after the Effective Date, when due.

 2.6         Withholding. Payments received by Lenders
from Borrower hereunder will be made free and clear of any withholding taxes. Specifically, however, if at any time any Governmental Authority, applicable law, regulation or international agreement requires Borrower to make any such withholding or
deduction from any such payment or other sum payable hereunder to Lenders, Borrower hereby covenants and agrees that the amount due from Borrower with respect to such payment or other sum payable hereunder will be increased to the extent necessary
to ensure that, after the making of such required withholding or deduction, each Lender receives a net sum equal to the sum which it would have received had no withholding or deduction been required and Borrower shall pay the full amount withheld or
deducted to the relevant Governmental Authority. Borrower will, upon request, furnish Lenders with proof reasonably satisfactory to Lenders indicating that Borrower has made such withholding payment provided, however, that Borrower need not make any
withholding payment if the amount or validity of such withholding payment is contested in good faith by appropriate and timely proceedings and as to which payment in full is bonded or reserved against by Borrower. The agreements and obligations of
Borrower contained in this Section 2.6 shall survive the termination of this Agreement. 
  

	 	 3
	 CONDITIONS OF LOANS 

 3.1         Conditions Precedent to Initial Credit Extension. Each Lender’s obligation to make a Term A Loan is subject to the condition
precedent that Collateral Agent shall consent to or shall have received, in form and substance satisfactory to Collateral Agent, such documents, and completion of such other matters, as Collateral Agent may reasonably deem necessary or appropriate,
including, without limitation: 
 (a)         duly executed original
signatures to the Loan Documents to which Borrower is a party; 
 (b)
        duly executed original signatures to Control Agreements with Bank of America, Royal Bank of Canada and Capital Advisors Group/State Street; 

(c)         duly executed original Secured Promissory Notes in favor of each
Lender according to its Term A Loan Commitment Percentage; 
 (d)
        the Operating Documents of Zalicus and a good standing certificate of Zalicus certified by the Secretary of State of the State of Delaware; 

(e)         good standing certificates for Zalicus certified by the Secretary of
State of the States of New Jersey and Washington and the Commonwealths of Massachusetts and Pennsylvania and each other state in which Zalicus is qualified to conduct business, each as of a date no earlier than thirty (30) days prior to the
Effective Date; 
 (f)         the Operating Documents of Zalicus-Canada
and good standing certificates of Zalicus-Canada certified by the British Columbia Registrar of Companies and each jurisdiction in which Zailcus-Canada is registered to conduct business in Canada, each as of a date no earlier than thirty
(30) days prior to the Effective Date; 
 (g)         the
Perfection Certificates for Zalicus and Zalicus-Canada; 

  
 4 

 (h)         duly executed original
signatures to an officer’s certificate for Zalicus, in a form acceptable to Collateral Agent; 
 (i)
        duly executed original signatures to an officer’s certificate for Zalicus-Canada, in a form acceptable to Collateral Agent; 

(j)         Collateral Agent shall have received certified copies, dated as of a
recent date, of financing statement searches, as Collateral Agent shall request, accompanied by written evidence (including any UCC termination statements) that the Liens indicated in any such financing statements either constitute Permitted Liens
or have been or, in connection with the initial Credit Extension, will be terminated or released; 
 (k)
        a landlord’s consent executed in favor of Collateral Agent in respect of Borrower’s locations at 245 First Street, Third Floor, Cambridge, Massachusetts 02142 and 301-2389 Health Sciences
Mall, Vancouver, British Columbia V6T 1Z3 Canada; 
 (l)         a copy
of any applicable Registration Rights Agreement or Investors’ Rights Agreement and any amendments thereto; 

(m)         a legal opinion of Zalicus’ United States counsel dated as of
the Effective Date together with the duly executed original signatures thereto; 
 (n)
        a legal opinion of Zalicus-Canada’s Canadian counsel dated as of the Effective Date together with the duly executed original signatures thereto; 

(o)         evidence satisfactory to Collateral Agent that the insurance policies
required by Section 6.5 hereof are in full force and effect, together with appropriate evidence showing loss payable and/or additional insured clauses or endorsements in favor of Collateral Agent, for the ratable benefit of the Lenders; and

 (p)         payment of the fees and Lenders’ Expenses then due
as specified in Section 2.5 hereof. 
 3.2
        Conditions Precedent to all Credit Extensions. The obligation of each Lender to make each Credit Extension, including the initial Credit Extension, is subject to the following conditions
precedent: 
 (a)         receipt by Collateral Agent of an executed
Payment/Advance Form in the form of Exhibit B attached hereto; 
 (b)
        the representations and warranties in Section 5 hereof shall be true, accurate and complete in all material respects on the date of the Payment/Advance Form and on the Funding Date of each Credit
Extension; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations
and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date, and no Event of Default shall have occurred and be continuing or result from the Credit Extension. Each Credit
Extension is Borrower’s representation and warranty on that date that the representations and warranties in Section 5 hereof are true, accurate and complete in all material respects; provided, however, that such materiality qualifier shall
not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof; and provided, further that those representations and warranties expressly referring to a specific date shall be true,
accurate and complete in all material respects as of such date; 
 (c)
        in such Lender’s reasonable discretion, there has not been any Material Adverse Change; and 
 (d)         payment of the fees and Lenders’ Expenses then due as specified in Section 2.5 hereof. 

  
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 3.3         Covenant to
Deliver. Borrower agrees to deliver to Collateral Agent each item required to be delivered to Collateral Agent under this Agreement as a condition precedent to any Credit Extension. Borrower expressly agrees that a Credit Extension made prior to
the receipt by Collateral Agent of any such item shall not constitute a waiver by the Lenders of Borrower’s obligation to deliver such item, and any such Credit Extension in the absence of a required item shall be made in each Lender’s
sole discretion. 
 3.4         Procedures for Borrowing.
Subject to the prior satisfaction of all other applicable conditions to the making of a Term Loan set forth in this Agreement, to obtain a Term Loan, Borrower shall notify Collateral Agent (which notice shall be irrevocable) by electronic mail,
facsimile, or telephone by 12:00 noon Eastern time three (3) Business Days prior to the date the Term Loan is to be made. Together with any such electronic or facsimile notification, Borrower shall deliver to Collateral Agent by electronic mail
or facsimile a completed Payment/Advance Form executed by a Responsible Officer or his or her designee. Upon receipt of a Payment/Advance Form, Collateral Agent shall promptly provide a copy of the same to each Lender. Collateral Agent may rely on
any telephone notice given by a person whom Collateral Agent reasonably believes is a Responsible Officer or designee. On the Funding Date, each Lender shall credit and/or transfer (as applicable) to Borrower’s Designated Deposit Account, an
amount equal to its Term Loan Commitment. 
  

	 	 4
	 CREATION OF SECURITY INTEREST 

4.1         Grant of Security Interest. Borrower and Guarantor each
hereby grants Collateral Agent, for the ratable benefit of the Lenders, to secure the payment and performance in full of all of the Obligations, a continuing security interest in, and pledges to Collateral Agent, for the ratable benefit of the
Lenders, the Collateral, wherever located, whether now owned or hereafter acquired or arising, and all proceeds and products thereof. Borrower and Guarantor each represents, warrants, and covenants that the security interest granted herein is and
shall at all times continue to be a first priority perfected security interest in the Collateral, subject only to Permitted Liens that are permitted by the terms of this agreement to have priority to Collateral Agent’s Lien. If Borrower or
Guarantor shall acquire a commercial tort claim (as defined in the Code), Borrower or Guarantor, as the case may be, shall promptly notify Collateral Agent in a writing signed by Borrower or Guarantor, as the case may be, of the general details
thereof (and further details as may be required by Collateral Agent) and grant to Collateral Agent, for the ratable benefit of the Lenders, in such writing a security interest therein and in the proceeds thereof, all upon the terms of this
Agreement, with such writing to be in form and substance reasonably satisfactory to Collateral Agent. 
 If this Agreement is terminated, Collateral Agent’s Lien in the Collateral shall continue until the Obligations (other than inchoate indemnity obligations) are repaid in full in cash. Upon payment in
full in cash of the Obligations and at such time as the Lenders’ obligation to make Credit Extensions has terminated, Collateral Agent shall, at Borrower’s sole cost and expense, release its Liens in the Collateral and all rights therein
shall revert to Borrower or Guarantor, as applicable. 
 4.2
        Authorization to File Financing Statements. Borrower and Guarantor hereby authorize Collateral Agent to file financing statements or take any other action required to prefect Collateral
Agent’s security interests in the Collateral, without notice to Borrower or Guarantor, with all appropriate jurisdictions to perfect or protect Collateral Agent’s and each Lender’s interest or rights hereunder, including a notice that
any disposition of the Collateral, except to the extent permitted by the terms of this Agreement, by either Borrower, Guarantor or any other Person, shall be deemed to violate the rights of Collateral Agent and Lenders under the Code or the PPSA, as
applicable. Such financing statements may indicate the Collateral as “all assets of the Debtor other than Debtor’s Intellectual Property” or words of similar effect, or as being of an equal or lesser scope, or with greater detail, all
in Collateral Agent’s discretion, provided that such financing statements shall note the assets excluded from Collateral as specified on Exhibit A hereto. 
  

	 	 5
	 REPRESENTATIONS AND WARRANTIES 

Borrower and Guarantor represent and warrant to Collateral Agent and the Lenders as follows at all times: 

5.1         Due Organization, Authorization: Power and Authority.
Borrower, Guarantor and each of their respective Subsidiaries is duly existing and Borrower is in good standing as Registered Organizations in its jurisdiction of organization and Borrower, Guarantor, and each of their respective Subsidiaries is
qualified and licensed to do business and is in good standing in any 

  
 6 

 
jurisdiction in which the conduct of its business or its ownership of property requires that it be qualified except where the failure to do so could not reasonably be expected to have a material
adverse effect on Borrower’s business. In connection with this Agreement, Borrower has delivered to Collateral Agent a completed perfection certificate signed by an officer of Borrower (the “Perfection Certificate”). Borrower
represents and warrant that (a) Borrower’s exact legal name is that indicated on the Perfection Certificate and on the signature page hereof; (b) Borrower is an organization of the type and is organized in the jurisdiction set forth
in the Perfection Certificate; (c) the Perfection Certificate accurately sets forth Borrower’s organizational identification number or accurately states that Borrower has none; (d) the Perfection Certificate accurately sets forth
Borrower’s place of business, or, if more than one, its chief executive office as well as Borrower’s mailing address (if different than its chief executive office); (e) except as disclosed on the Perfection Certificate, Borrower (and
each of their respective predecessors) has not, in the past five (5) years, changed its jurisdiction of organization, organizational structure or type, or any organizational number assigned by its jurisdiction of organization; and (f) all
other information set forth on the Perfection Certificate pertaining to Borrower and each of their respective Subsidiaries is accurate and complete (it being understood and agreed that Borrower may from time to time update certain information in the
Perfection Certificates (including the information set forth in clause (d) above) after the Effective Date to the extent permitted by one or more specific provisions in this Agreement). If Borrower, Guarantor or any Subsidiary is not now a
Registered Organization but later becomes one, Borrower shall notify Collateral Agent of such occurrence and provide Collateral Agent with such Person’s organizational identification number within five (5) Business Days of receiving such
organizational identification number. 
 The execution, delivery and performance by Borrower or Guarantor of the
Loan Documents to which it is a party have been duly authorized, and do not (i) conflict with any of Borrower’s or Guarantor’s organizational documents, including the Operating Documents, (ii) contravene, conflict with,
constitute a default under or violate any material Requirement of Law, (iii) contravene, conflict or violate any applicable order, writ, judgment, injunction, decree, determination or award of any Governmental Authority by which Borrower,
Guarantor or any of their respective Subsidiaries or any of their property or assets may be bound or affected, (iv) require any action by, filing, registration, or qualification with, or Governmental Approval from, any Governmental Authority
(except such Governmental Approvals which have already been obtained and are in full force and effect) or are being obtained pursuant to Section 6.1(b), or (v) constitute an event of default under any material agreement by which Borrower,
Guarantor or any of their respective Subsidiaries or their respective properties is bound. Neither Borrower nor Guarantor is in default under any agreement to which it is a party or by which it or any of its assets is bound in which such default
could reasonably be expected to have a Material Adverse Change. 
  

	 	 5.2
	 Collateral. 

 (a)         Borrower and Guarantor have good title to, has rights in, and the power to transfer each item of the Collateral upon which it purports to grant a Lien
under the Loan Documents, free and clear of any and all Liens except Permitted Liens, and neither Borrower nor Guarantor has any Deposit Accounts, Securities Accounts, Commodity Accounts or other investment accounts other than the Collateral
Accounts or the other investment accounts, if any, described in the Perfection Certificate delivered to Collateral Agent in connection herewith with respect of which Borrower or Guarantor has given Collateral Agent notice and taken such actions as
are necessary to give Collateral Agent a perfected security interest therein. The Accounts are bona fide, existing obligations of the Account Debtors. 
 (b)         On the Effective Date, except for Clinical Testing Assets having a value not exceeding Two Hundred Thousand Dollars ($200,000) individually or in the
aggregate, the Collateral is not in the possession of any third party bailee (such as a warehouse) except as disclosed in the Perfection Certificate, and, as of the Effective Date, no such third party bailee possesses components of the Collateral
(other than Clinical Testing Assets having a value not exceeding Two Hundred Thousand Dollars ($200,000) individually or in the aggregate) in excess of Fifty Thousand Dollars ($50,000). Except for mobile equipment (such as laptop computers and
mobile phones) in the possession of Borrower’s employees and agents, none of the components of the Collateral shall be maintained at locations other than as disclosed in the Perfection Certificate on the Effective Date or as permitted pursuant
to Section 7.2. In the event that Borrower or Guarantor, after the Effective Date, intends to store or otherwise deliver any portion of the Collateral (other than Clinical Testing Assets having a value not exceeding Two Hundred Thousand Dollars
($200,000) individually or in the aggregate) to a bailee in excess of Fifty Thousand Dollars ($50,000), then Borrower or Guarantor, as applicable, will first receive the written consent of Collateral Agent and such bailee must execute and deliver a
bailee agreement in form and 

  
 7 

 
substance reasonably satisfactory to Collateral Agent. The term “Clinical Testing Assets” shall include all products or equipment included on Borrower’s balance sheet which is
maintained at pre-clinical and clinical testing sites. Notwithstanding the foregoing, “Clinical Testing Assets” does not include products or equipment located with manufacturers or distributors of Borrower. 

(c)         All Inventory is in all material respects of good and marketable
quality, free from material defects. 
 (d)         Borrower and
Guarantor are the sole owners of the Intellectual Property each respectively owns or purports to own, except for (i) non-exclusive licenses granted to its customers in the ordinary course of business, (ii) Permitted Intellectual Property
Licenses, (iii) over-the-counter software that is commercially available to the public, and (iv) material Intellectual Property licensed to Borrower and noted on the Perfection Certificate. Each of Borrower’s and Guarantor’s
Patents that it owns or purports to own and is material to its business is valid and enforceable (with respect to issued patents) or includes patentable claims (with respect to pending patent applications) and no part of the Intellectual Property
that it owns or purports to own and is material to its business has been judged invalid or unenforceable, in whole or in part, and to Borrower’s and Guarantor’s knowledge, no claim has been made that any part of the Intellectual Property
or any practice by Borrower or Guarantor violates the rights of any third party except to the extent such claim has not resulted in and could not reasonably be expected to result in a Material Adverse Change. Except as noted on the Perfection
Certificate, neither Borrower nor Guarantor is a party to, nor is bound by, any material license or other agreement with respect to which Borrower or Guarantor is the licensee that (i) prohibits or otherwise restricts Borrower or Guarantor from
granting a security interest in Borrower’s or Guarantor’s interest in such license or agreement or any other property, or (ii) for which a default under or termination of could interfere with Collateral Agent’s right to sell any
Collateral. Borrower and Guarantor shall provide written notice to Collateral Agent within ten (10) days of entering into or becoming bound by any such license or agreement (other than over-the-counter software that is commercially available to
the public). Borrower and Guarantor shall take such commercially reasonable steps as Collateral Agent requests to obtain the consent of, or waiver by, any Person whose consent or waiver is necessary for (i) all such licenses or agreements to be
deemed “Collateral” and for Collateral Agent to have a security interest in it that might otherwise be restricted or prohibited by law or by the terms of any such license or agreement, whether now existing or entered into in the future,
and (ii) Collateral Agent shall have the ability in the event of a liquidation of any Collateral to dispose of such Collateral in accordance with Collateral Agent’s rights and remedies under this Agreement and the other Loan Documents.

 5.3         Litigation. Except as disclosed on the
Perfection Certificate, there are no actions, suits, investigations, or proceedings pending or, to the knowledge of the Responsible Officers, threatened in writing by or against Borrower, Guarantor or any of their respective Subsidiaries involving
more than Two Hundred Thousand Dollars ($200,000.00). 
 5.4
        No Material Deterioration in Financial Condition; Financial Statements. All consolidated financial statements for Borrower, Guarantor and their respective Subsidiaries delivered to Collateral
Agent fairly present, in all material respects the consolidated financial condition of Borrower, Guarantor and their respective Subsidiaries and the consolidated results of operations of Borrower, Guarantor and their respective Subsidiaries. There
has not been any material deterioration in the consolidated financial condition of Borrower, Guarantor and their respective Subsidiaries since the date of the most recent financial statements submitted to Collateral Agent. 

5.5         Solvency. The fair salable value of Borrower’s
assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities; Borrower is not left with unreasonably small capital after the transactions in this Agreement; and Borrower is able to pay its debts (including trade
debts) as they mature. The fair salable value of Guarantor’s assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities; Guarantor is not left with unreasonably small capital after the transactions in this
Agreement; and Guarantor is able to pay its debts (including trade debts) as they mature. 
 5.6
        Regulatory Compliance. Borrower is not an “investment company” or a company “controlled” by an “investment company” under the Investment Company Act of 1940, as
amended. Zalicus-Canada is not a “mutual fund” as defined in the Securities Act (British Columbia). Borrower is not engaged as one of its important activities in extending credit for margin stock (under Regulations X, T and U of the
Federal Reserve Board of Governors). Borrower has complied in all material respects with the 

  
 8 

 
Federal Fair Labor Standards Act and the Employment Standards Act (British Columbia) as applicable. Neither Borrower nor any of its Subsidiaries is a “holding company” or an
“affiliate” of a “holding company” or a “subsidiary company” of a “holding company” as each term is defined and used in the Public Utility Holding Company Act of 2005 or the Securities Act (British Columbia),
as applicable. Borrower has not violated any laws, ordinances or rules, the violation of which has had or could reasonably be expected to have a Material Adverse Change. None of Borrower’s or any of its Subsidiaries’ properties or assets
has been used by Borrower or any Subsidiary or, to Borrower’s knowledge, by previous Persons, in disposing, producing, storing, treating, or transporting any hazardous substance other than in material compliance with applicable laws. Borrower
and each of its Subsidiaries have obtained all consents, approvals and authorizations of, made all declarations or filings with, and given all notices to, all Governmental Authorities that are necessary to continue their respective businesses as
currently conducted. 
 None of Borrower, Guarantor or their respective Affiliates or any of
their respective agents acting or benefiting in any capacity in connection with the transactions contemplated by this Agreement is (i) in violation of any Anti-Terrorism Law, (ii) engages in or conspires to engage in any transaction that
evades or avoids, or has the purpose of evading or avoiding or attempts to violate, any of the prohibitions set forth in any Anti-Terrorism Law, or (iii) is a Blocked Person. Neither Borrower, Guarantor nor, to the knowledge of Borrower and
Guarantor, any of their Affiliates or agents acting or benefiting in any capacity in connection with the transactions contemplated by this Agreement, (x) conducts any business or engages in making or receiving any contribution of funds, goods
or services to or for the benefit of any Blocked Person, or (y) deals in, or otherwise engages in any transaction relating to, any property or interest in property blocked pursuant to Executive Order No. 13224, any similar executive order
or other Anti-Terrorism Law. 
 5.7         Subsidiaries;
Investments. Neither Borrower nor Guarantor owns any stock, shares, partnership interests or other equity securities except for Permitted Investments. 
 5.8         Tax Returns and Payments; Pension Contributions. Borrower, Guarantor and their respective Subsidiaries have timely filed all required tax
returns and reports, and Borrower, Guarantor and their respective Subsidiaries have timely paid all foreign, federal, state, and local taxes, assessments, deposits and contributions owed by Borrower, Guarantor and their respective Subsidiaries in
all jurisdictions in which Borrower, Guarantor or their respective Subsidiaries are subject to taxes, including the United States, unless such taxes are being contested in accordance with the following sentence. Borrower, Guarantor and their
respective Subsidiaries may defer payment of any contested taxes, provided that Borrower or Guarantor or such Subsidiary (a) in good faith contests its obligation to pay the taxes by appropriate proceedings promptly and diligently instituted
and conducted, (b) notifies Collateral Agent in writing of the commencement of, and any material development in, the proceedings, and (c) posts bonds or takes any other steps required to prevent the governmental authority levying such
contested taxes from obtaining a Lien upon any of the Collateral that is other than a “Permitted Lien”. Borrower and Guarantor are unaware of any claims or adjustments proposed for any of Borrower, Guarantor or their respective
Subsidiaries prior tax years which could result in additional taxes becoming due and payable by Borrower, Guarantor or their respective subsidiaries. Borrower, Guarantor and their respective Subsidiaries have paid all amounts necessary to fund all
present pension, profit sharing and deferred compensation plans in accordance with their terms, and Borrower, Guarantor and their respective Subsidiaries have not withdrawn from participation in, and has not permitted partial or complete termination
of, or permitted the occurrence of any other event with respect to, any such plan which could reasonably be expected to result in any liability of Borrower, Guarantor or their respective Subsidiaries, including any liability to the Pension Benefit
Guaranty Corporation or its successors or any other governmental agency, as applicable. 
 5.9
        Use of Proceeds. Borrower shall use the proceeds of the Credit Extensions solely as working capital and to fund its general business requirements in accordance with the provisions of this
Agreement, and not for personal, family, household or agricultural purposes. 
 5.10
        Full Disclosure. No written representation, warranty or other statement of Borrower in any certificate or written statement given to Collateral Agent or any Lender, as of the date such
representation, warranty, or other statement was made, taken together with all such written certificates and written statements given to Collateral Agent or any Lender, contains any untrue statement of a material fact or omits to state a material
fact necessary to make the statements contained in the certificates or statements not misleading (it being recognized that the projections and forecasts provided by Borrower in good faith and based upon reasonable assumptions are not viewed as facts
and that actual results during the period or periods covered by such projections and forecasts may differ from the projected or forecasted results). 

  
 9 

  

	 	 6
	 AFFIRMATIVE COVENANTS 

Borrower and Guarantor shall, and shall cause each of their respective subsidiaries to, do all of the
following: 
 6.1         Government Compliance. 

(a)         Except as permitted by Section 7.3, maintain its and all its
Subsidiaries’ legal existence and good standing in their respective jurisdictions of organization and maintain qualification in each jurisdiction in which the failure to so qualify could reasonably be expected to have a material adverse effect
on Borrower’s business or operations. Borrower and Guarantor shall comply, and have each Subsidiary comply, with all laws, ordinances and regulations to which it is subject, the noncompliance with which could reasonably be expected to have a
material adverse effect on Borrower’s business. 
 (b)
        Obtain and keep in full force and effect, all of the Governmental Approvals necessary for the performance by Borrower and Guarantor of their obligations under the Loan Documents and the grant of a
security interest to Collateral Agent for the ratable benefit of the Lenders, in all of the Collateral. Borrower and Guarantor shall promptly provide copies to Collateral Agent of any material Governmental Approvals obtained by Borrower or
Guarantor. 
  

	 	 6.2        Financial
	 Statements, Reports, Certificates. 

(a)         Deliver to Collateral Agent: (i) as soon as available, but no
later than forty-five (45) days after the last day of each of its first three fiscal quarters, a company prepared consolidated financial statements prepared under GAAP (except for the absence of footnotes and subject to normal year-end
adjustments), consistently applied and consolidating balance sheet, and income statement covering the consolidated operations of Borrower, Guarantor, and their respective Subsidiaries for such month certified by a Responsible Officer and in a form
reasonably acceptable to Collateral Agent; (ii) as soon as available, but no later than one hundred twenty (120) days after the last day of Borrower’s fiscal year, audited consolidated financial statements prepared under GAAP,
consistently applied, together with an unqualified opinion (other than a “going concern” qualification) on the financial statements from a nationally-recognized independent certified public accounting firm; (iii) as soon as available,
but no later than sixty (60) days after the last day of each of Borrower’s fiscal years, Borrower’s financial budget, in a form reasonably acceptable to Lenders, for the entire current fiscal year (on a quarterly basis) as
approved by Borrower’s Board of Directors; (iv) within five (5) days of delivery, copies of all statements, reports and notices made available to Borrower’s security holders or holders of Subordinated Debt; (v) within five
(5) days of filing, all reports on Form 10-K, 10-Q and 8-K filed with the Securities and Exchange Commission (other than confidential treatment requests), which documents may be delivered electronically and if so delivered, shall be deemed to
have been delivered on the date on which Borrower provides Collateral Agent with a link thereto on Borrower’s website, (vi) prompt notice of (A) any material adverse change in the composition of the Intellectual Property that is
material to Borrower’s business, (B) the invalidation of any material patent of borrower that is material to Borrower’s business, and (C) Borrower’s knowledge of any event that could reasonably be expected to materially and
adversely affect the value of the Intellectual Property; (vii) as soon as available, but no later than thirty (30) days after the last day of each month, copies of the month-end bank statements for each deposit account or securities
account maintained by Borrower, or Guarantor or any Subsidiary, which bank statements may be provided to Collateral Agent by Borrower or directly from the applicable bank(s), and (viii) other financial information as reasonably requested by
Collateral Agent. 
 (b)         Concurrently with the delivery of the
financial statements specified in Section 6.2(a)(i) above, deliver to Collateral Agent, a duly completed Compliance Certificate signed by a Responsible Officer. 

(c)         Keep proper books of record and account in accordance with GAAP in
all material respects, in which full, true and correct entries shall be made of all dealings and transactions in relation to its business and activities. Borrower shall allow, at the sole cost of Borrower (not to exceed $1,200 per day, excluding
out-of-pocket expenses), Collateral Agent and Lenders, during regular 

  
 10 

 
business hours upon reasonable prior notice (except while an Event of Default has occurred and is continuing), to visit and inspect any of its properties, to examine and make abstracts or copies
from any of its books and records, and to conduct a collateral audit and analysis of its operations and the Collateral. Such audits shall be conducted no more often than twice every twelve months unless an Event of Default has occurred and is
continuing. 
 6.3         Inventory; Returns. Keep all
Inventory in good and marketable condition, free from material defects. Returns and allowances between Borrower, Guarantor and their Account Debtors shall follow Borrower’s or Guarantor’s customary practices as they exist at the Effective
Date. Borrower and Guarantor must promptly notify Collateral Agent of all returns, recoveries, disputes and claims that involve more than Two Hundred Thousand Dollars ($200,000) individually or in the aggregate in any calendar year. 

6.4         Taxes; Pensions. Timely file and require each of its
Subsidiaries to timely file, all required tax returns and reports and timely pay, and require each of its Subsidiaries to timely file, all foreign, federal, state, and local taxes, assessments, deposits and contributions owed by Borrower, Guarantor
and each of their respective Subsidiaries, except for deferred payment of any taxes contested pursuant to the terms of Section 5.8 hereof, and shall deliver to Collateral Agent, on demand, appropriate certificates attesting to such payments,
and pay all amounts necessary to fund all present pension, profit sharing and deferred compensation plans in accordance with their terms. 
 6.5         Insurance. Keep its business and the Collateral insured for risks and in amounts standard for companies in Borrower’s and
Guarantor’s industry and location and as Collateral Agent may reasonably request. Insurance policies shall be in a form, with companies, and in amounts that are reasonably satisfactory to Collateral Agent. All property policies shall have a
lender’s loss payable endorsement showing Collateral Agent as lender loss payee and waive subrogation against Collateral Agent, and all general liability policies shall show, or have endorsements showing, Collateral Agent, as an additional
insured. All policies (or the loss payable and additional insured endorsements) shall provide that the insurer shall endeavor to give Collateral Agent at least thirty (30) days notice before canceling, amending (with respect to property
policies only), reducing, or declining to renew its policy. At Collateral Agent’s request, Borrower shall deliver certified copies of policies and evidence of all premium payments. Proceeds payable under any policy shall, at Collateral
Agent’s option, be payable to Collateral Agent on behalf of the Lenders on account of the Obligations. Notwithstanding the foregoing, (a) so long as no Event of Default has occurred and is continuing, Borrower shall have the option of
applying the proceeds of any casualty policy up to $100,000 with respect to any loss, but not exceeding $250,000, in the aggregate for all losses under all casualty policies in any one year, toward the replacement or repair of destroyed or damaged
property; provided that any such replaced or repaired property (i) shall be of equal or like value as the replaced or repaired Collateral and (ii) shall be deemed Collateral in which Collateral Agent has been granted a first priority
security interest, and (b) after the occurrence and during the continuance of an Event of Default, all proceeds payable under such casualty policy shall, at the option of Collateral Agent, be payable to Collateral Agent, for the ratable benefit
of the Lenders, on account of the Obligations. If Borrower or Guarantor fails to obtain insurance as required under this Section 6.5 or to pay any amount or furnish any required proof of payment to third persons and Collateral Agent, Collateral
Agent may make all or part of such payment or obtain such insurance policies required in this Section 6.5, and take any action under the policies Collateral Agent deems prudent. 

6.6         Operating Accounts. 

(a)         Maintain all of Borrower’s and Guarantor’s and all of their
Subsidiaries’ operating and other deposit accounts and securities accounts with Bank of America, Royal Bank of Canada and Capital Advisors Group/State Street in accounts which are subject to a Control Agreement in favor of Collateral Agent;
notwithstanding the foregoing, Borrower may maintain account #3300536717 with Silicon Valley Bank (the “SVB Account”) until June 30, 2011, provided, however, that the amount on deposit in such account shall not exceed One Hundred
Thousand Dollars ($100,000) at any time. 
 (b)         Borrower,
Guarantor and their respective Subsidiaries shall provide Collateral Agent five (5) days’ prior written notice before establishing any Collateral Account at or with any Person other than Bank of America, Royal Bank of Canada and Capital
Advisors Group/State Street. In addition, for each Collateral Account that Borrower or Guarantor or any of their Subsidiaries any time maintains, Borrower shall cause the applicable bank or financial institution at or with which such Collateral
Account is maintained to execute and deliver a Control Agreement or other appropriate instrument with respect to such Collateral Account to perfect Collateral Agent’s Lien in such Collateral Account in accordance with the terms hereunder, which
Control Agreement may 

  
 11 

 
not be terminated without prior written consent of Collateral Agent. The provisions of the previous sentence shall not apply to deposit accounts exclusively used for payroll, payroll taxes and
other employee wage and benefit payments to or for the benefit of Borrower’s or Guarantor’s or such Subsidiary’s employees and identified to Collateral Agent by Borrower or Guarantor as such or the SVB Account provided that the amount
on deposit in such account does not exceed One Hundred Thousand Dollars ($100,000) at any time. 
 (c)
        Borrower, Guarantor, and their respective Subsidiaries shall not maintain any Collateral Accounts except Collateral Accounts located in the United States and Canada in accordance with Sections 6.6(a)
and (b). 
 6.7         Protection of Intellectual Property
Rights. Borrower and Guarantor each shall: (a) use commercially reasonable efforts to protect, defend and maintain the validity and enforceability of its Intellectual Property that is material to Borrower’s business; (b) promptly
advise Collateral Agent in writing of material infringement by a third party of its Intellectual Property; and (c) not allow any Intellectual Property material to Borrower’s business to be abandoned, forfeited (excluding terminal
disclaimers in Patents that are filed in the ordinary course of Borrower’s business) or dedicated to the public without Collateral Agent’s written consent. 

6.8         Litigation Cooperation. From the date hereof and
continuing through the termination of this Agreement, make available to Collateral Agent, without expense to Collateral Agent or the Lenders, Borrower and its officers, employees and agents and Borrower’s Books, to the extent that Collateral
Agent may reasonably deem them necessary to prosecute or defend any third-party suit or proceeding instituted by or against Collateral Agent or the Lenders with respect to any Collateral or relating to Borrower. 

6.9         Notices of Litigation and Default. Borrower will give prompt
written notice to Collateral Agent of any litigation or governmental proceedings pending or threatened (in writing) against Borrower, Guarantor or any of their Subsidiaries which could reasonably be expected to result in damages or costs to
Borrower, Guarantor or any of their Subsidiaries of Two Hundred Thousand Dollars ($200,000) or more or which has resulted in or could reasonably be expected to result in a Material Adverse Change. Without limiting or contradicting any other more
specific provision of this Agreement, promptly (and in any event within three (3) Business Days) upon Borrower becoming aware of the existence of any Event of Default or event which, with the giving of notice or passage of time, or both, would
constitute an Event of Default, Borrower shall give written notice to Collateral Agent of such occurrence, which such notice shall include a reasonably detailed description of such Event of Default or event which, with the giving of notice or
passage of time, or both, would constitute an Event of Default. 
 6.10
        Creation/Acquisition of Subsidiaries. In the event Borrower, Guarantor or any Subsidiary creates or acquires any Subsidiary, Borrower, Guarantor and such Subsidiary shall promptly notify
Collateral Agent of the creation or acquisition of such new Subsidiary and take all such action as may be reasonably required by Collateral Agent to cause each such Subsidiary to become a co-Borrower hereunder or to guarantee the Obligations of
Borrower under the Loan Documents and, in each case, grant a continuing pledge and security interest in and to the assets of such Subsidiary (substantially as described on Exhibit A hereto); and Borrower or Guarantor, as
applicable, shall grant and pledge to Collateral Agent, for the ratable benefit of the Lenders, a perfected security interest in the stock, units or other evidence of ownership of each Subsidiary. 

6.11         Neuromed Pharmaceuticals, Inc. On or before
June 30, 2011, Borrower shall cause Neuromed Pharmaceuticals, Inc., a Delaware corporation and a wholly-owned subsidiary of Zalicus (“Neuromed”), to be either (i) liquidated and dissolved with all of Neuromed’s
assets, if any, distributed to Zalicus, or (ii) merged with and into Zalicus with Zalicus being the surviving corporation. On and after the Effective Date and prior to such dissolution or merger, Borrower shall not, and shall not permit any
Subsidiary to, (i) make any Investment in Neuromed except for monies necessary to finance the expenses of such dissolution or merger in an aggregate amount not to exceed $20,000 or (ii) permit Neuromed to incur any liabilities or
Indebtedness (other than liabilities existing on the Effective Date in respect of a real property lease for certain property located in Conshohocken, Pennsylvania, which lease expires on December 31, 2010). 

  
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 6.12         0797733 B.C.
Ltd. On or before June 30, 2011, Borrower shall cause 0797733 B.C. Ltd., a corporation organized under the laws of British Columbia, Canada a wholly-owned subsidiary of Zalicus-Canada (“0797733 B.C. Ltd.”), to be either
(i) liquidated and dissolved with all of 0797733 B.C. Ltd.’s assets, if any, distributed to Zalicus-Canada, or (ii) merged with and into Zalicus-Canada with Zalicus-Canada being the surviving corporation. On and after the Effective
Date and prior to such dissolution or merger, Borrower shall not, and shall not permit any Subsidiary to, (i) make any Investment in 0797733 B.C. Ltd. except for monies necessary to finance the expenses of such dissolution or merger in an
aggregate amount not to exceed $20,000 or (ii) permit 0797733 B.C. Ltd. to incur any liabilities or Indebtedness. 
 6.13         Zalicus Securities Corporation. On and after the Effective Date, Borrower shall not, and shall not permit any Subsidiary to,
(i) make any Investment in Zalicus Securities Corporation, a Massachusetts corporation and a wholly-owned subsidiary of Zalicus (“Zalicus Securities”), other than Investments which do not exceed $250,000 in the aggregate,
(ii) permit Zalicus Securities to incur any liabilities or Indebtedness or (iii) permit Zalicus Securities to engage in any business activity other than such business activities as are necessary to qualify as, and permissible to be engaged
in by, a “Massachusetts Securities Corporation” pursuant to Massachusetts General Laws (MGL) chapter 63, section 38b. 
 6.14         Further Assurances. 
 (a)         Execute any further instruments and take further action as Collateral Agent reasonably requests to perfect or continue Collateral Agent’s Lien in
the Collateral or to effect the purposes of this Agreement. 
 (b)
        Deliver to Collateral Agent, within five (5) days after the same are sent or received, copies of all material correspondence, reports, documents and other filings with any Governmental Authority
that could reasonably be expected to have a material adverse effect on any of the Governmental Approvals material to Borrower’s business or otherwise on the operations of Borrower or any of its Subsidiaries. 

 

	 	 7
	 NEGATIVE COVENANTS 

Borrower and Guarantor shall not, and shall not permit any of their respective Subsidiaries to, do any of
the following without the prior written consent of the Required Lenders: 
 7.1
        Dispositions. Convey, sell, lease, transfer, assign, or otherwise dispose of (collectively, “Transfer”), or permit any of its Subsidiaries to Transfer, all or any part of its
business or property, except for Transfers (a) of Inventory in the ordinary course of business; (b) of worn-out, obsolete or surplus Equipment; (c) in connection with Permitted Liens and Permitted Investments; (d) Permitted
Intellectual Property Licenses; (e) Transfers of property to the extent permitted by clause (e) of the definition of Permitted indebtedness; and (f) other Transfers in an aggregate amount not to exceed $50,000 in any fiscal year. In
no event shall Borrower be permitted to Transfer its rights, title and interest in or to the Exalgo Agreements or any royalty or other payments thereunder or other proceeds thereof without the prior written consent of Lenders. 

7.2         Changes in Business, Management, Ownership, or Business
Locations. (a) Engage in or permit any of its Subsidiaries to engage in any business other than the businesses engaged in by Borrower and Guarantor as of the Effective Date or reasonably related thereto; (b) liquidate or dissolve; or
(c) any Key Person shall cease to be actively engaged in the management of Borrower unless a replacement or interim replacement for such Key Person, is approved by Borrower’s Board of Directors and engaged by Borrower within one hundred
twenty (120) days, or (ii) permit or suffer any Change in Control. Neither Borrower nor Guarantor shall, without at least thirty (30) days prior written notice to Collateral Agent: (A) add any new offices or business locations,
including warehouses (unless such new offices or business locations contain less than One Hundred Thousand Dollars ($100,000), individually or in the aggregate, in Borrower’s or Guarantor’s assets or property), (B) change its
jurisdiction of organization, (C) change its organizational structure or type, (D) change its legal name, or (E) change any organizational number (if any) assigned by its jurisdiction of organization. 

7.3         Mergers or Acquisitions. Merge or consolidate, or
permit any of its Subsidiaries to merge or consolidate, with any other Person, or acquire, or permit any of its Subsidiaries to acquire, all or substantially all of the capital stock, shares or property of another Person, except for Permitted
Acquisitions. A Subsidiary may merge or consolidate into another Subsidiary (provided such surviving Subsidiary is a “co-Borrower” hereunder or has provided a secured guaranty of Borrower’s Obligations hereunder) or into Borrower or
Guarantor provided Borrower or Guarantor is the surviving legal entity, and as long as no Event of Default is occurring prior thereto or arises as a result therefrom. 

  
 13 

 7.4
        Indebtedness. Create, incur, assume, or be liable for any Indebtedness, or permit any Subsidiary to do so, other than Permitted Indebtedness. 

7.5         Encumbrance. Create, incur, allow, or suffer any Lien
on any of its property, or assign or convey any right to receive income, including the sale of any Accounts, or permit any of its Subsidiaries to do so, except for Permitted Liens, or permit any Collateral not to be subject to the first priority
security interest granted herein (except for Permitted Liens that are permitted by the terms of this agreement to have priority to Collateral Agent’s Lien), or enter into any agreement, document, instrument or other arrangement (except with or
in favor of Collateral Agent) with any Person which directly or indirectly prohibits or has the effect of prohibiting Borrower, Guarantor or any Subsidiary from assigning, mortgaging, pledging, granting a security interest in or upon, or encumbering
any of Borrower’s, Guarantor’s or any Subsidiary’s Intellectual Property, except as is otherwise permitted in Section 7.1 hereof and the definition of “Permitted Liens” herein. 

7.6         Maintenance of Collateral Accounts. Maintain any
Collateral Account except pursuant to the terms of Section 6.6 hereof. 
 7.7
        Distributions; Investments. (a) Pay any dividends (other than dividends payable solely in capital stock) or make any distribution or payment or redeem, retire or purchase any capital stock
(other than repurchases pursuant to the terms of employee stock purchase plans, employee restricted stock agreements, stockholder rights plans, director or consultant stock option plans, or similar plans, provided such repurchases do not exceed One
Hundred Thousand Dollars ($100,000) in the aggregate per fiscal year) or (b) directly or indirectly make any Investment other than Permitted Investments, or permit any of its Subsidiaries to do so. 

7.8         Transactions with Affiliates. Directly or indirectly
enter into or permit to exist any material transaction with any Affiliate of Borrower or Guarantor, except for transactions that are in the ordinary course of Borrower’s or Guarantor’s business, upon fair and reasonable terms that are no
less favorable to Borrower or Guarantor than would be obtained in an arm’s length transaction with a non-affiliated Person and transactions among the entities constituting “Borrower”. 

7.9         Subordinated Debt. (a) Make or permit any payment
on any Subordinated Debt, except under the terms of the subordination, intercreditor, or other similar agreement to which such Subordinated Debt is subject, or (b) amend any provision in any document relating to the Subordinated Debt which
would increase the amount thereof or adversely affect the subordination thereof to Obligations owed to the Lenders. 
 7.10         Compliance. Become an “investment company” or a company controlled by an “investment company”, under the Investment
Company Act of 1940, as amended, become a “mutual company” under the Securities Act (British Columbia), or undertake as one of its important activities extending credit to purchase or carry margin stock (as defined in Regulation U of the
Board of Governors of the Federal Reserve System), or use the proceeds of any Credit Extension for that purpose; fail to meet the minimum funding requirements of (a) ERISA or (b) any Canadian employee benefit plan or pension plan, permit a
Reportable Event or Prohibited Transaction, as defined in ERISA, to occur; fail to comply with the Federal Fair Labor Standards Act or the Employment Standards Act (British Columbia), as applicable, or violate any other law or regulation, if the
violation could reasonably be expected to have a material adverse effect on Borrower’s business, or permit any of its Subsidiaries to do so; withdraw or permit any Subsidiary to withdraw from participation in, permit partial or complete
termination of, or permit the occurrence of any other event with respect to, any present pension, profit sharing and deferred compensation plan which could reasonably be expected to result in any liability of Borrower, including any liability to the
Pension Benefit Guaranty Corporation or its successors or any other governmental agency. 
 7.11
        Compliance with Anti-Terrorism Laws. Collateral Agent hereby notifies Borrower and Guarantor that pursuant to the requirements of Anti-Terrorism Laws, and Collateral Agent’s policies and
practices, Collateral Agent is required to obtain, verify and record certain information and documentation that identifies Borrower and Guarantor and their principals, which information includes the name and address of Borrower and Guarantor and
their principals and such other information that will allow Collateral 

  
 14 

 
Agent to identify such party in accordance with Anti-Terrorism Laws. Neither Borrower nor Guarantor will, nor will Borrower or Guarantor permit any Subsidiary or Affiliate to, directly or
indirectly, knowingly enter into any documents, instruments, agreements or contracts with any Person listed on the OFAC Lists. Borrower and Guarantor shall immediately notify Collateral Agent if Borrower or Guarantor has knowledge that Borrower,
Guarantor or any Subsidiary or Affiliate is listed on the OFAC Lists or (a) is convicted on, (b) pleads nolo contendere to, (c) is indicted on, or (d) is arraigned and held over on charges involving money laundering or
predicate crimes to money laundering. Neither Borrower nor Guarantor will, nor will Borrower or Guarantor permit any Subsidiary or Affiliate to, directly or indirectly, (i) conduct any business or engage in any transaction or dealing with any
Blocked Person, including, without limitation, the making or receiving of any contribution of funds, goods or services to or for the benefit of any Blocked Person, (ii) deal in, or otherwise engage in any transaction relating to, any property
or interests in property blocked pursuant to Executive Order No. 13224, any similar executive order or other Anti-Terrorism Law, or (iii) engage in or conspire to engage in any transaction that evades or avoids, or has the purpose of
evading or avoiding, or attempts to violate, any of the prohibitions set forth in Executive Order No. 13224 or other Anti-Terrorism Law. 
  

	 	 8
	 EVENTS OF DEFAULT 

Any one of the following shall constitute an event of default (an “Event of Default”)
under this Agreement: 
 8.1         Payment Default.
Borrower fails to (a) make any payment of principal or interest on any Credit Extension on its due date, or (b) pay any other Obligations within three (3) Business Days after such Obligations are due and payable (which three
(3) Business Day grace period shall not apply to payments due on the Maturity Date or the date of acceleration pursuant to Section 9.1 (a) hereof). During the cure period, the failure to cure the payment default is not an Event of
Default (but no Credit Extension will be made during the cure period); 
 8.2
        Covenant Default. 
 (a)
        Borrower or Guarantor fails or neglects to perform any obligation in Sections 6.2 (Financial Statements, Reports, Certificates), 6.4 (Taxes), 6.5 (Insurance), 6.6 (Operating Accounts), 6.7 (Protection
of Intellectual Property Rights), 6.9 (Notices of Default), 6.10 (Creation/Acquisition of Subsidiaries), 6.11 (Neuromed Pharmaceuticals, Inc., 6.12 (0797733 B.C. Ltd), or 6.13 (Zalicus Securities Corporation) or Borrower or violates any covenant in
Section 7; or 
 (b)         Borrower, Guarantor or any of their
Subsidiaries fails or neglects to perform, keep, or observe any other term, provision, condition, covenant or agreement contained in this Agreement or any Loan Documents, and as to any default (other than those specified in this Section 8)
under such other term, provision, condition, covenant or agreement that can be cured, has failed to cure the default within ten (10) days after the occurrence thereof; provided, however, that if the default cannot by its nature be cured within
the ten (10) day period or cannot after diligent attempts by Borrower be cured within such ten (10) day period, and such default is likely to be cured within a reasonable time, then Borrower shall have an additional period (which shall not
in any case exceed thirty (30) days) to attempt to cure such default, and within such reasonable time period the failure to cure the default shall not be deemed an Event of Default (but no Credit Extensions shall be made during such cure
period). Grace periods provided under this Section shall not apply, among other things, to any other covenants set forth in subsection (a) above; 
 8.3         Material Adverse Change. A Material Adverse Change occurs; 

8.4         Attachment; Levy; Restraint on Business. 

(a)         (i) The service of process seeking to attach, by trustee or similar
process, any funds of Borrower or Guarantor or of any entity under control of Borrower or Guarantor (including a Subsidiary) on deposit with any Lender or any Lender’s Affiliate or any bank or other institution at which Borrower or Guarantor
maintains a Collateral Account, or (ii) a notice of lien, levy, or assessment is filed against any of Borrower’s or Guarantor’s assets by any government agency, and the same under subclauses (i) and (ii) hereof are not,
within ten (10) days after the occurrence thereof, discharged or stayed (whether through the posting of a bond or otherwise); provided, however, no Credit Extensions shall be made during any ten (10) day cure period; and 

  
 15 

 (b)         (i) any material portion
of Borrower’s or Guarantor’s assets is attached, seized, levied on, or comes into possession of a trustee or receiver, or (ii) any court order enjoins, restrains, or prevents Borrower or Guarantor from conducting any part of its
business; 
 8.5         Insolvency (a) Borrower or
Guarantor is unable to pay its debts (including trade debts) generally as they become due or otherwise becomes insolvent; (b) Borrower or Guarantor begins an Insolvency Proceeding; or (c) an Insolvency Proceeding is begun against Borrower
or Guarantor and not dismissed or stayed within forty-five (45) days (but no Credit Extensions shall be made while any of the conditions described in clause (a) exist and/or until any Insolvency Proceeding is dismissed); 

8.6         Other Agreements. There is a default in any agreement
to which Borrower or Guarantor is a party with a third party or parties resulting in a right by such third party or parties, whether or not exercised, to accelerate the maturity of any Indebtedness in an amount in excess of Two Hundred Thousand
Dollars ($200,000) or that could have a material adverse effect on Borrower’s business. 
 8.7
        Judgments. One or more judgments, orders, or decrees for the payment of money in an amount, individually or in the aggregate, of at least Two Hundred Thousand Dollars ($200,000) (not covered by
independent third-party insurance as to which liability has been accepted by such insurance carrier) shall be rendered against Borrower or Guarantor and shall remain unsatisfied, unvacated, or unstayed for a period of ten (10) days after the
entry thereof (provided that no Credit Extensions will be made prior to the satisfaction, vacation, or stay of such judgment, order or decree); 
 8.8         Misrepresentations. Borrower or any Person acting for Borrower makes any representation, warranty, or other statement now or later in this
Agreement, any Loan Document or in any writing delivered to Collateral Agent and/or Lenders or to induce Collateral Agent and/or the Lenders to enter this Agreement or any Loan Document, and such representation, warranty, or other statement is
incorrect in any material respect when made; 
 8.9
        Subordinated Debt. A default or breach occurs under any agreement between Borrower and any creditor of Borrower that signed a subordination, intercreditor, or other similar agreement with
Collateral Agent or the Lenders, or any creditor that has signed such an agreement with Collateral Agent or the Lenders breaches any terms of such agreement; or 

8.10         Governmental Approvals. Any material Governmental
Approval shall have been (a) revoked, rescinded, suspended, modified in an adverse manner or not renewed in the ordinary course for a full term or (b) subject to any decision by a Governmental Authority that designates a hearing with
respect to any applications for renewal of any of such Governmental Approval or that could result in the Governmental Authority taking any of the actions described in clause (a) above, and such decision or such revocation, rescission,
suspension, modification or non-renewal (i) has, or could reasonably be expected to have, a Material Adverse Change, or (ii) adversely affects the legal qualifications of Borrower, Guarantor or any of their respective Subsidiaries to hold
such Governmental Approval in any applicable jurisdiction and such revocation, rescission, suspension, modification or non-renewal could reasonably be expected to affect the status of or legal qualifications of Borrower or any of its Subsidiaries to
hold any Governmental Approval in any other jurisdiction that could reasonably be expected to have a material adverse effect on Borrower’s business. 
 8.11         Lien Priority. Any Lien created hereunder or by any other Loan Document shall at any time fail to constitute a valid and perfected Lien on any
of the Collateral purported to be secured thereby, subject to no prior or equal Lien, other than Permitted Liens. 
  

	 	 9
	 RIGHTS AND REMEDIES 

 9.1         Rights and Remedies. 

  
 16 

 (a)         Upon the occurrence and
during the continuance of an Event of Default, Collateral Agent may, and at the written direction of any Lender shall, without notice or demand, do any or all of the following: (i) deliver notice of the Event of Default to Borrower,
(ii) by notice to Borrower declare all Obligations immediately due and payable (but if an Event of Default described in Section 8.5 occurs all Obligations shall be immediately due and payable without any action by Collateral Agent or the
Lenders) or (iii) by notice to Borrower suspend or terminate the obligations, if any, of the Lenders to advance money or extend credit for Borrower’s benefit under this Agreement or under any other agreement between Borrower and Collateral
Agent and/or the Lenders (but if an Event of Default described in Section 8.5 occurs all obligations, if any, of the Lenders to advance money or extend credit for Borrower’s benefit under this Agreement or under any other agreement between
Borrower and Collateral Agent and/or the Lenders shall be immediately terminated without any action by Collateral Agent or the Lenders). 
 (b)         Without limiting the rights of the Collateral Agent and the Lenders set forth in Section 9.1(a) above, upon the occurrence and during the
continuance of an Event of Default Collateral Agent shall have the right, at the written direction of the Required Lenders, without notice or demand, to do any or all of the following: 

(i)         foreclose upon and/or sell or otherwise liquidate, the Collateral;

 (ii)         apply to the Obligations any (a) balances and
deposits of Borrower that Collateral Agent or any Lender holds or controls, or (b) any amount held or controlled by Collateral Agent or any Lender owing to or for the credit or the account of Borrower; and/or 

(iii)         commence and prosecute an Insolvency Proceeding or consent to
Borrower commencing any Insolvency Proceeding. 
 (c)         Without
limiting the rights of the Collateral Agent and the Lenders set forth in Sections 9.1(a) and (b) above, upon the occurrence and during the continuance of an Event of Default Collateral Agent shall have the right, without notice or demand, to do
any or all of the following: 
 (i)         settle or adjust disputes
and claims directly with Account Debtors for amounts on terms and in any order that Collateral Agent considers advisable, notify any Person owing Borrower money of Collateral Agent’s security interest in such funds, and verify the amount of
such account; 
 (ii)         make any payments and do any acts it
considers necessary or reasonable to protect the Collateral and/or its security interest in the Collateral. Borrower shall assemble the Collateral if Collateral Agent requests and make it available in a location as Collateral Agent reasonably
designates. Collateral Agent may peaceably enter premises where the Collateral is located, take and maintain possession of any part of the Collateral, and pay, purchase, contest, or compromise any Lien which appears to be prior or superior to its
security interest and pay all expenses incurred. Borrower grants Collateral Agent a license to enter and occupy any of its premises, without charge, to exercise any of Collateral Agent’s rights or remedies; 

(iii)         ship, reclaim, recover, store, finish, maintain, repair, prepare
for sale, and/or advertise for sale, the Collateral. Collateral Agent is hereby granted a non-exclusive, royalty-free license or other right to use, without charge, Borrower’s labels, patents, copyrights, mask works, rights of use of any name,
trade secrets, trade names, trademarks, service marks, and advertising matter, or any similar property as it pertains to the Collateral, in completing production of, advertising for sale, and selling any Collateral and, in connection with Collateral
Agent’s exercise of its rights under this Section 9.1, Borrower’s rights under all licenses and all franchise agreements inure to Collateral Agent for the benefit of the Lenders; 

(iv)         place a “hold” on any account maintained with Collateral
Agent or the Lenders and/or deliver a notice of exclusive control, any entitlement order, or other directions or instructions pursuant to any Control Agreement or similar agreements providing control of any Collateral; 

(v)         demand and receive possession of Borrower’s Books; 

  
 17 

 (vi)         appoint a receiver to
seize, manage and realize any of the Collateral, and such receiver shall have any right and authority as any competent court will grant or authorize in accordance with any applicable law, including any power or authority to manage the business of
Borrower or Guarantor; and 
 (vii)         Subject to clauses 9.1(a)
and (b), exercise all rights and remedies available to Collateral Agent under the Loan Documents or at law or equity, including all remedies provided under the Code or PPSA (including disposal of the Collateral pursuant to the terms thereof).

 Notwithstanding any provision of this Section 9.1 to the contrary, upon the occurrence of any Event of Default,
Collateral Agent shall have the right to exercise any and all remedies referenced in this Section 9.1 without the written consent of Required Lenders following the occurrence of an Exigent Circumstance. As used in the immediately preceding
sentence, “Exigent Circumstance” means any event or circumstance that, in the reasonable judgment of Collateral Agent, imminently threatens the ability of Collateral Agent to realize upon all or any material portion of the Collateral, such
as, without limitation, fraudulent removal, concealment, or abscondment thereof, destruction or material waste thereof, or failure of Borrower after reasonable demand to maintain or reinstate adequate casualty insurance coverage, or which, in the
judgment of Collateral Agent, could reasonably be expected to result in a material diminution in value of the Collateral. 
 9.2         Power of Attorney.   Borrower hereby irrevocably appoints Collateral Agent as its lawful attorney-in-fact, exercisable upon the
occurrence and during the continuance of an Event of Default, to: (a) endorse Borrower’s name on any checks or other forms of payment or security; (b) sign Borrower’s name on any invoice or bill of lading for any Account or
drafts against Account Debtors; (c) settle and adjust disputes and claims about the Accounts directly with Account Debtors, for amounts and on terms Collateral Agent determines reasonable; (d) make, settle, and adjust all claims under
Borrower’s insurance policies; (e) pay, contest or settle any Lien, charge, encumbrance, security interest, and adverse claim in or to the Collateral, or any judgment based thereon, or otherwise take any action to terminate or discharge
the same; and (f) transfer the Collateral into the name of Collateral Agent or a third party as the Code or PPSA or any applicable law permits. Borrower hereby appoints Collateral Agent as its lawful attorney-in-fact to sign Borrower’s
name on any documents necessary to perfect or continue the perfection of Collateral Agent’s security interest in the Collateral regardless of whether an Event of Default has occurred until all Obligations (other than inchoate indemnity
obligations) have been satisfied in full and Collateral Agent and the Lenders are under no further obligation to make Credit Extensions hereunder. Collateral Agent’s foregoing appointment as Borrower’s attorney in fact, and all of
Collateral Agent’s rights and powers, coupled with an interest, are irrevocable until all Obligations (other than inchoate indemnity obligations) have been fully repaid and performed and Collateral Agent’s and the Lenders’ obligation
to provide Credit Extensions terminates. 
 9.3
        Protective Payments.   If Borrower fails to obtain the insurance called for by Section 6.5 or fails to pay any premium thereon or fails to pay any other amount which Borrower is
obligated to pay under this Agreement or any other Loan Document, Collateral Agent may obtain such insurance or make such payment, and all amounts so paid by Collateral Agent are Lenders’ Expenses and immediately due and payable, bearing
interest at the Default Rate, and secured by the Collateral. Collateral Agent will make reasonable efforts to provide Borrower with notice of Collateral Agent obtaining such insurance or making such payment at the time it is obtained or paid or
within a reasonable time thereafter. No such payments by Collateral Agent are deemed an agreement to make similar payments in the future or Collateral Agent’s waiver of any Event of Default. 

9.4         Application of Payments and Proceeds.
  Notwithstanding anything to the contrary contained in this Agreement, upon the occurrence and during the continuance of an Event of Default, (a) Borrower irrevocably waives the right to direct the application of any and all payments
at any time or times thereafter received by Collateral Agent from or on behalf of Borrower of all or any part of the Obligations, and, as between Borrower on the one hand and Collateral Agent and Lenders on the other, Collateral Agent shall have the
continuing and exclusive right to apply and to reapply any and all payments received against the Obligations in such manner as Collateral Agent may deem advisable notwithstanding any previous application by Collateral Agent, and (b) the
proceeds of any sale of, or other realization upon all or any part of the Collateral shall be applied: first, to the Lenders’ Expenses; second, to accrued and unpaid interest on the Obligations (including any interest which, but for the
provisions of the United States Bankruptcy Code, would have accrued on such amounts); third, to the principal amount of the Obligations outstanding; and fourth, to any other indebtedness or obligations of Borrower owing to Collateral Agent or any
Lender under the Loan Documents. Any balance remaining shall be delivered to Borrower or to whoever may be lawfully entitled to receive such balance or as a court of competent jurisdiction may direct. In carrying out the foregoing, (x) amounts
received shall be applied in the numerical order provided until exhausted 

  
 18 

 
prior to the application to the next succeeding category, and (y) each of the Persons entitled to receive a payment in any particular category shall receive an amount equal to its pro rata
share of amounts available to be applied pursuant thereto for such category. Any reference in this Agreement to an allocation between or sharing by the Lenders of any right, interest or obligation “ratably,” “proportionally” or
in similar terms shall refer to Pro Rata Share unless expressly provided otherwise. Collateral Agent, or if applicable, each Lender, shall promptly remit to the other Lenders such sums as may be necessary to ensure the ratable repayment of each
Lender’s portion of any Term Loan and the ratable distribution of interest, fees and reimbursements paid or made by Borrower. Notwithstanding the foregoing, a Lender receiving a scheduled payment shall not be responsible for determining whether
the other Lenders also received their scheduled payment on such date; provided, however, if it is later determined that a Lender received more than its ratable share of scheduled payments made on any date or dates, then such Lender shall remit to
Collateral Agent or other Lenders such sums as may be necessary to ensure the ratable payment of such scheduled payments, as instructed by Collateral Agent. Any payment or distribution of any kind or character, whether in cash, properties or
securities, shall be received by a Lender in excess of its ratable share, then the portion of such payment or distribution in excess of such Lender’s ratable share shall be received by such Lender in trust for and shall be promptly paid over to
the other Lender for application to the payments of amounts due on the other Lenders’ claims. To the extent any payment for the account of Borrower is required to be returned as a voidable transfer or otherwise, the Lenders shall contribute to
one another as is necessary to ensure that such return of payment is on a pro rata basis. If any Lender shall obtain possession of any Collateral, it shall hold such Collateral for itself and as agent and bailee for Collateral Agent and other
Lenders for purposes of perfecting Collateral Agent’s security interest therein. 
 9.5
        Liability for Collateral.   So long as Collateral Agent and the Lenders comply with applicable law and reasonable banking practices regarding the safekeeping of the Collateral in the
possession or under the control of Collateral Agent and the Lenders, Collateral Agent and the Lenders shall not be liable or responsible for: (a) the safekeeping of the Collateral; (b) any loss or damage to the Collateral; (c) any
diminution in the value of the Collateral; or (d) any act or default of any carrier, warehouseman, bailee, or other Person. Borrower bears all risk of loss, damage or destruction of the Collateral. 

9.6         No Waiver; Remedies Cumulative.   Collateral
Agent’s failure, at any time or times, to require strict performance by Borrower of any provision of this Agreement or any other Loan Document shall not waive, affect, or diminish any right of Collateral Agent thereafter to demand strict
performance and compliance herewith or therewith. No waiver hereunder shall be effective unless signed by Collateral Agent and then is only effective for the specific instance and purpose for which it is given. Collateral Agent’s rights and
remedies under this Agreement and the other Loan Documents are cumulative. Collateral Agent has all rights and remedies provided under the Code or PPSA, any applicable law, by law, or in equity. Collateral Agent’s exercise of one right or
remedy is not an election, and Collateral Agent’s waiver of any Event of Default is not a continuing waiver. Collateral Agent’s delay in exercising any remedy is not a waiver, election, or acquiescence. 

9.7         Demand Waiver.   Borrower waives, to the
fullest extent permitted by law, demand, notice of default or dishonor, notice of payment and nonpayment, notice of any default, nonpayment at maturity, release, compromise, settlement, extension, or renewal of accounts, documents, instruments,
chattel paper, and guarantees held by Collateral Agent on which Borrower is liable. 
 9.8
        Borrower Liability.   Either Borrower may, acting singly, request Term Loans hereunder. Each Borrower hereby appoints the other as agent for the other for all purposes hereunder,
including with respect to requesting Term Loans hereunder. Each Borrower hereunder shall be jointly and severally obligated to repay all Term Loans made hereunder and all other Obligations, regardless of which Borrower actually receives said Term
Loans, as if each Borrower hereunder directly received all Term Loans. Each Borrower waives (a) any suretyship defenses available to it under the Code or PPSA or any other applicable law, and (b) any right to require the Lenders or
the Collateral Agent to: (i) proceed against any Borrower or any other person; (ii) proceed against or exhaust any security; or (iii) pursue any other remedy. The Lenders or the Collateral Agent may exercise or not exercise any
right or remedy it has against any Borrower or any security it holds (including the right to foreclose by judicial or non-judicial sale) without affecting any Borrower’s liability. Notwithstanding any other provision of this Agreement or
other related document, each Borrower irrevocably waives all rights that it may have at law or in equity (including, without limitation, any law subrogating Borrower to the rights of the Lenders and the Collateral Agent under this Agreement) to seek
contribution, indemnification or any other form of reimbursement from any other Borrower, or any other Person now or hereafter primarily or secondarily liable for any 

  
 19 

 
of the Obligations, for any payment made by Borrower with respect to the Obligations in connection with this Agreement or otherwise and all rights that it might have to benefit from, or to
participate in, any security for the Obligations as a result of any payment made by Borrower with respect to the Obligations in connection with this Agreement or otherwise. Any agreement providing for indemnification, reimbursement or any other
arrangement prohibited under this Section shall be null and void. If any payment is made to a Borrower in contravention of this Section, such Borrower shall hold such payment in trust for the Lenders and the Collateral Agent and such payment
shall be promptly delivered to the Collateral Agent for application to the Obligations, whether matured or unmatured. 
  

	 	 10
	 NOTICES 

 All notices, consents, requests, approvals, demands, or other communication (collectively, “Communication”) by any party to this Agreement or any other Loan Document must be in writing
and shall be deemed to have been validly served, given, or delivered: (a) upon the earlier of actual receipt and three (3) Business Days after deposit in the U.S. mail, first class, registered or certified mail return receipt requested,
with proper postage prepaid; (b) upon transmission, when sent by facsimile transmission; (c) one (1) Business Day after deposit with a reputable overnight courier with all charges prepaid; or (d) when delivered, if hand-delivered
by messenger, all of which shall be addressed to the party to be notified and sent to the address, facsimile number, or email address indicated below. Any of Collateral Agent, Lender or Borrower may change its mailing or electronic mail address or
facsimile number by giving the other party written notice thereof in accordance with the terms of this Section 10. 
  

			
	 If to Borrower:
	 	 Zalicus Inc.

		 	 245 First Street

		 	 Third Floor

		 	 Cambridge, Massachusetts 02142

		 	 Attn: Chief Financial Officer

		 	 Fax: (617) 301-7108

		
	 with a copy to:
	 	 Zalicus Inc.

		 	 245 First Street, Third Floor

		 	 Cambridge, Massachusetts 02142

		 	 Attn: Jason Cole, Esq.

		 	 Fax: (617) 301-7010

		
	 If to Collateral Agent:
	 	 Oxford Finance Corporation

		 	 133 North Fairfax Street

		 	 Alexandria, Virginia 22314

		 	 Attention: General Counsel

		 	 Fax: (703) 519-5225

		
	 with a copy to:
	 	 Riemer & Braunstein LLP

		 	 Three Center Plaza

		 	 Boston, Massachusetts 02108

		 	 Attn: John J. Malloy, Esquire

		 	 Fax: (617) 880-3449

  

	 	 11
	 CHOICE OF LAW, VENUE AND JURY TRIAL WAIVER 

New York law governs the Loan Documents without regard to principles of conflicts of law. Borrower,
Lenders and Collateral Agent each submit to the exclusive jurisdiction of the State and Federal courts in the City of New York, Borough of Manhattan. NOTWITHSTANDING THE FOREGOING, COLLATERAL AGENT AND LENDERS SHALL HAVE THE RIGHT TO BRING ANY
ACTION OR PROCEEDING AGAINST BORROWER OR ITS PROPERTY IN THE COURTS OF ANY OTHER JURISDICTION WHICH COLLATERAL AGENT AND LENDERS (IN ACCORDANCE WITH THE 

  
 20 

 
PROVISIONS OF SECTION 9.1) DEEM NECESSARY OR APPROPRIATE TO REALIZE ON THE COLLATERAL OR TO OTHERWISE ENFORCE COLLATERAL AGENT’S AND LENDERS’ RIGHTS AGAINST BORROWER OR ITS PROPERTY.
Borrower expressly submits and consents in advance to such jurisdiction in any action or suit commenced in any such court, and Borrower hereby waives any objection that it may have based upon lack of personal jurisdiction, improper venue, or forum
non conveniens and hereby consents to the granting of such legal or equitable relief as is deemed appropriate by such court. Borrower hereby waives personal service of the summons, complaints, and other process issued in such action or suit and
agrees that service of such summons, complaints, and other process may be made by registered or certified mail addressed to Borrower at the address set forth in Section 10 of this Agreement and that service so made shall be deemed completed
upon the earlier to occur of Borrower’s actual receipt thereof or three (3) days after deposit in the U.S. mails, first class, registered or certified mail return receipt requested, proper postage prepaid. 

TO THE FULLEST EXTENT PERMITTED BY APPLICABLE LAW, BORROWER, COLLATERAL AGENT, AND LENDERS EACH WAIVE THEIR RIGHT TO A
JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION ARISING OUT OF OR BASED UPON THIS AGREEMENT, THE LOAN DOCUMENTS OR ANY CONTEMPLATED TRANSACTION, INCLUDING CONTRACT, TORT, BREACH OF DUTY AND ALL OTHER CLAIMS. THIS WAIVER IS A MATERIAL INDUCEMENT FOR THE
PARTIES TO ENTER INTO THIS AGREEMENT. EACH PARTY HAS REVIEWED THIS WAIVER WITH ITS COUNSEL. 
  

	 	 12
	 GENERAL PROVISIONS 

 12.1         Successors and Assigns.     This Agreement binds and is for the benefit of the successors and permitted assigns of
each party. Borrower may not assign this Agreement or any rights or obligations under it without Collateral Agent’s prior written consent (which may be granted or withheld in Collateral Agent’s discretion, subject to Section 12.6).
The Lenders have the right, without the consent of or notice to Borrower, to sell, transfer, assign, negotiate, or grant participation in (any such sale, transfer, assignment, negotiation, or grant of a participation, a “Lender
Transfer”) all or any part of, or any interest in, the Lenders’ obligations, rights, and benefits under this Agreement and the other Loan Documents provided, however, that any such Lender Transfer (other than a sale or
assignment to an Eligible Assignee) of its obligations, rights, and benefits under this Agreement and the other Loan Documents shall require the prior written consent of the Required Lenders (such approved assignee, an “Approved
Lender”). Borrower and Collateral Agent shall be entitled to continue to deal solely and directly with such Lender in connection with the interests so assigned until Collateral Agent shall have received and accepted an effective assignment
agreement in form satisfactory to Collateral Agent executed, delivered and fully completed by the applicable parties thereto, and shall have received such other information regarding such Eligible Assignee or Approved Lender as Collateral Agent
reasonably shall require. 
 12.2         Indemnification.
    Borrower agrees to indemnify, defend and hold Collateral Agent and the Lenders and their respective directors, officers, employees, agents, attorneys, or any other Person affiliated with or representing Collateral Agent or
the Lenders (each, an “Indemnified Person”) harmless against: (a) all obligations, demands, claims, and liabilities (collectively, “Claims”) asserted by any other party in connection with the transactions
contemplated by the Loan Documents; and (b) all losses or Lenders’ Expenses incurred, or paid by Indemnified Person from, following, or arising from transactions between Collateral Agent, and/or the Lenders and Borrower (including
reasonable attorneys’ fees and expenses), except for Claims and/or losses directly caused by such Indemnified Person’s gross negligence or willful misconduct. Borrower hereby further indemnifies, defends and holds each Indemnified Person
harmless from and against any and all liabilities, obligations, losses, damages, penalties, actions, judgments, suits, claims, costs, expenses and disbursements of any kind or nature whatsoever (including the fees and disbursements of counsel for
such Indemnified Person) in connection with any investigative, response, remedial, administrative or judicial matter or proceeding, whether or not such Indemnified Person shall be designated a party thereto and including any such proceeding
initiated by or on behalf of Borrower, and the reasonable expenses of investigation by engineers, environmental consultants and similar technical personnel and any commission, fee or compensation claimed by any broker (other than any broker retained
by Collateral Agent or Lenders) asserting any right to payment for the transactions contemplated hereby which may be imposed on, incurred by or asserted against such Indemnified Person as a result of or in connection with the transactions
contemplated hereby and the use or intended use of the proceeds of the loan proceeds. 

  
 21 

 12.3         Time of
Essence. Time is of the essence for the performance of all Obligations in this Agreement. 
 12.4
        Severability of Provisions. Each provision of this Agreement is severable from every other provision in determining the enforceability of any provision. 

12.5         Correction of Loan Documents. Collateral Agent and the
Lenders may correct patent errors and fill in any blanks in this Agreement and the other Loan Documents consistent with the agreement of the parties, so long as Collateral Agent provides Borrower with written notice of such correction and allows
Borrower at least ten (10) days to object to such correction. In the event of such objection, such correction shall not be made except by an amendment signed by both Collateral Agent and Borrower. 

12.6         Amendments in Writing; Integration. (a) No
amendment, modification, termination or waiver of any provision of this Agreement or any other Loan Document, no approval or consent thereunder, or any consent to any departure by Borrower or Guarantor therefrom, shall in any event be effective
unless the same shall be in writing and signed by Borrower, Guarantor, Collateral Agent and the Required Lenders provided that 
 (i)         no such amendment, waiver or other modification that would have the effect of increasing or reducing a Lender’s Term Loan Commitment or Commitment
Percentage shall be effective as to such Lender without such Lender’s written consent; 

(ii)         no such amendment, waiver or modification that would
affect the rights and duties of Collateral Agent shall be effective without Collateral Agent’s written consent or signature; 
 (iii)         no such amendment, waiver or other modification shall, unless signed by all the Lenders directly affected thereby, (A) reduce the principal of,
rate of interest on or any fees with respect to any Term Loan or forgive any principal, interest (other than default interest) or fees (other than late charges) with respect to any Term Loan (B) postpone the date fixed for, or waive, any
payment of principal of any Term Loan or of interest on any Term Loan (other than default interest) or any fees provided for hereunder (other than late charges or for any termination of any commitment); (C) change the definition of the term
“Required Lenders” or the percentage of Lenders which shall be required for Lenders to take any action hereunder; (D) release all or substantially all or any material portion of the Collateral, authorize Borrower to sell or otherwise
dispose of all or substantially all or any material portion of the Collateral or release any Guarantor of all or any portion of the Obligations or its guaranty obligations with respect thereto, except, in each case with respect to this clause (D),
as otherwise may be expressly permitted under this Agreement or the other Loan Documents (including in connection with any disposition permitted hereunder); (E) amend, waive or otherwise modify this Section 12.6 or the definitions of the
terms used in this Section 12.6 insofar as the definitions affect the substance of this Section 12.6; (F) consent to the assignment, delegation or other transfer by Borrower or Guarantor of any of its rights and obligations under any
Loan Document or release Borrower or Guarantor of its payment obligations under any Loan Document, except, in each case with respect to this clause (F), pursuant to a merger or consolidation permitted pursuant to this Agreement; (G) amend any
of the provisions of Section 9.4 or amend any of the definitions Pro Rata Share, Term Loan Commitment, Commitment Percentage or that provide for the Lenders to receive their Pro Rata Shares of any fees, payments, setoffs or proceeds of
Collateral hereunder; (H) subordinate the Liens granted in favor of Collateral Agent securing the Obligations; or (I) amend any of the provisions of Section 12.10. It is hereby understood and agreed that all Lenders shall be deemed
directly affected by an amendment, waiver or other modification of the type described in the preceding clauses (C), (D), (E), (F), (G) and (H) of the preceding sentence; 

(iv)         the provisions of the foregoing clauses (i),
(ii) and (iii) are subject to the provisions of any interlender or agency agreement among the Lenders and Collateral Agent pursuant to which any Lender may agree to give its consent in connection with any amendment, waiver or modification
of the Loan Documents only in the event of the unanimous agreement of all Lenders. 
 (b)
        Other than as expressly provided for in Section 12.6(a)(i)-(iii), Collateral Agent may, if requested by the Required Lenders, from time to time designate covenants in this Agreement less
restrictive by notification to a representative of Borrower. 

  
 22 

 (c)         This
Agreement and the Loan Documents represent the entire agreement about this subject matter and supersede prior negotiations or agreements. All prior agreements, understandings, representations, warranties, and negotiations between the parties about
the subject matter of this Agreement and the Loan Documents merge into this Agreement and the Loan Documents. 

12.7         Counterparts.     This Agreement
may be executed in any number of counterparts and by different parties on separate counterparts, each of which, when executed and delivered, is an original, and all taken together, constitute one Agreement. 

12.8         Survival.     All covenants,
representations and warranties made in this Agreement continue in full force until this Agreement has terminated pursuant to its terms and all Obligations (other than inchoate indemnity obligations and any other obligations which, by their terms,
are to survive the termination of this Agreement) have been satisfied. The obligation of Borrower in Section 12.2 to indemnify each Lender and Collateral Agent, as well as the confidentiality provisions in Section 12.9 below, shall survive
until the statute of limitations with respect to such claim or cause of action shall have run. 
 12.9
        Confidentiality.     In handling any confidential information of Borrower, the Lenders and Collateral Agent shall exercise the same degree of care that it exercises for their
own proprietary information, but disclosure of information may be made: (a) to the Lenders’ and Collateral Agent’s Subsidiaries or Affiliates; (b) to prospective transferees or purchasers of any interest in the Credit Extensions
(provided, however, the Lenders and Collateral Agent shall use commercially reasonable efforts to obtain such prospective transferee’s or purchaser’s agreement to the terms of this provision); (c) as required by law, regulation,
subpoena, or other order; (d) to Lenders’ or Collateral Agent’s regulators or as otherwise required in connection with an examination or audit; (e) as Collateral Agent considers appropriate in exercising remedies under the Loan
Documents; and (f) to third party service providers of the Lenders and/or Collateral Agent so long as such service providers have executed a confidentiality agreement with the Lenders and Collateral Agent with terms no less restrictive than
those contained herein. Confidential information does not include information that either: (i) is in the public domain or in the Lenders’ and/or Collateral Agent’s possession when disclosed to the Lenders and/or Collateral Agent, or
becomes part of the public domain after disclosure to the Lenders and/or Collateral Agent; or (ii) is disclosed to the Lenders and/or Collateral Agent by a third party, if the Lenders and/or Collateral Agent does not know that the third party
is prohibited from disclosing the information. Collateral Agent and the Lenders may use confidential information for any purpose, including, without limitation, for the development of client databases, reporting purposes, and market analysis, so
long as Collateral Agent does not disclose Borrower’s identity or the identity of any person associated with Borrower unless otherwise expressly permitted by this Agreement. The provisions of the immediately preceding sentence shall survive the
termination of this Agreement. 
 12.10         Right of
Set Off.     Borrower hereby grants to Collateral Agent and to each Lender, a lien, security interest and right of set off as security for all Obligations to Collateral Agent and each Lender hereunder, whether now
existing or hereafter arising upon and against all deposits, credits, collateral and property, now or hereafter in the possession, custody, safekeeping or control of Collateral Agent or the Lenders or any entity under the control of Collateral Agent
or the Lenders (including a Collateral Agent affiliate) or in transit to any of them. At any time after the occurrence and during the continuance of an Event of Default, without demand or notice, Collateral Agent or the Lenders may set off the same
or any part thereof and apply the same to any Obligation of Borrower regardless of the adequacy of any other collateral securing the Obligations. ANY AND ALL RIGHTS TO REQUIRE COLLATERAL AGENT TO EXERCISE ITS RIGHTS OR REMEDIES WITH RESPECT TO ANY
OTHER COLLATERAL WHICH SECURES THE OBLIGATIONS, PRIOR TO EXERCISING ITS RIGHT OF SETOFF WITH RESPECT TO SUCH DEPOSITS, CREDITS OR OTHER PROPERTY OF BORROWER ARE HEREBY KNOWINGLY, VOLUNTARILY AND IRREVOCABLY WAIVED. 

 

	 	 13
	 COLLATERAL AGENT 

 13.1         Appointment and Authorization of Collateral Agent.     Each Lender hereby irrevocably appoints, designates and
authorizes Collateral Agent to take such action on its behalf under the provisions of this Agreement and each other Loan Document and to exercise such powers and perform such duties as are expressly delegated to it by the terms of this Agreement or
any other Loan Document, together with such powers as are reasonably incidental thereto. Notwithstanding any provision to the contrary contained elsewhere herein or in any other Loan Document, Collateral Agent shall not have any duties or
responsibilities, except those expressly set forth herein, nor shall Collateral Agent have or be deemed to have any fiduciary relationship with any Lender or participant, and 

  
 23 

 
no implied covenants, functions, responsibilities, duties, obligations or liabilities shall be read into this Agreement or any other Loan Document or otherwise exist against Collateral Agent.
Without limiting the generality of the foregoing sentence, the use of the term “agent” herein and in the other Loan Documents with reference to Collateral Agent is not intended to connote any fiduciary or other implied (or express)
obligations arising under agency doctrine of any applicable law. Instead, such term is used merely as a matter of market custom, and is intended to create or reflect only an administrative relationship between independent contracting parties.

 13.2         Delegation of Duties.
    Collateral Agent may execute any of its duties under this Agreement or any other Loan Document by or through its, or its Affiliates’, agents, employees or attorneys-in-fact and shall be entitled to obtain and rely upon
the advice of counsel and other consultants or experts concerning all matters pertaining to such duties. Collateral Agent shall not be responsible for the negligence or misconduct of any agent or attorney-in-fact that it selects in the absence of
gross negligence or willful misconduct. 
 13.3
        Liability of Collateral Agent.     Except as otherwise provided herein, no Collateral Agent-Related Person shall (a) be liable for any action taken or omitted to be
taken by any of them under or in connection with this Agreement or any other Loan Document or the transactions contemplated hereby (except for its own gross negligence or willful misconduct in connection with its duties expressly set forth herein),
or (b) be responsible in any manner to any Lender or participant for any recital, statement, representation or warranty made by Borrower or any officer thereof, contained herein or in any other Loan Document, or in any certificate, report,
statement or other document referred to or provided for in, or received by Collateral Agent under or in connection with, this Agreement or any other Loan Document, or the validity, effectiveness, genuineness, enforceability or sufficiency of this
Agreement or any other Loan Document, or for any failure of Borrower or any other party to any Loan Document to perform its obligations hereunder or thereunder. No Collateral Agent-Related Person shall be under any obligation to any Lender or
participant to ascertain or to inquire as to the observance or performance of any of the agreements contained in, or conditions of, this Agreement or any other Loan Document, or to inspect the properties, books or records of Borrower or any
Affiliate thereof. 
 13.4         Reliance by Collateral
Agent.     Collateral Agent shall be entitled to rely, and shall be fully protected in relying, upon any writing, communication, signature, resolution, representation, notice, consent, certificate, affidavit, letter,
telegram, facsimile, telex or telephone message, electronic mail message, statement or other document or conversation believed by it to be genuine and correct and to have been signed, sent or made by the proper Person or Persons, and upon advice and
statements of legal counsel (including counsel to Borrower), independent accountants and other experts selected by Collateral Agent. Collateral Agent shall be fully justified in failing or refusing to take any action under any Loan Document unless
it shall first receive such advice or concurrence of all Lenders as it deems appropriate and, if it so requests, it shall first be indemnified to its satisfaction by the Lenders against any and all liability and expense which may be incurred by it
by reason of taking or continuing to take any such action. Collateral Agent shall in all cases be fully protected in acting, or in refraining from acting, under this Agreement or any other Loan Document in accordance with a request or consent of all
Lenders and such request and any action taken or failure to act pursuant thereto shall be binding upon all the Lenders. 
 13.5         Notice of Default.     Collateral Agent shall not be deemed to have knowledge or notice of the occurrence of any
default and/or Event of Default, unless Collateral Agent shall have received written notice from a Lender or Borrower, describing such default or Event of Default. Collateral Agent will notify the Lenders of its receipt of any such notice.
Collateral Agent shall take such action with respect to an Event of Default as may be directed in writing by the Required Lenders in accordance with Article 9(a); provided, however, that while an Event of Default has occurred and is
continuing, Collateral Agent may (but shall not be obligated to) take such action, or refrain from taking such action, with respect to such Event of Default as Collateral Agent shall deem advisable or in the best interest of the Lenders, including
without limitation, satisfaction of other security interests, liens or encumbrances on the Collateral not permitted under the Loan Documents, payment of taxes on behalf of Borrower, payments to landlords, warehouseman, bailees and other persons in
possession of the Collateral and other actions to protect and safeguard the Collateral, and actions with respect to insurance claims for casualty events affecting Borrower and/or the Collateral. 

13.6         Credit Decision; Disclosure of Information by Collateral
Agent.     Each Lender acknowledges that no Collateral Agent-Related Person has made any representation or warranty to it, and that no act by Collateral Agent hereafter taken, including any consent to and acceptance of any
assignment or review of the affairs of Borrower or any Affiliate thereof, shall be deemed to constitute any representation or warranty by any Collateral Agent-Related Person to any Lender as to any matter, including whether

  
 24 

 
Collateral Agent-Related Persons have disclosed material information in their possession. Each Lender represents to Collateral Agent that it has, independently and without reliance upon any
Collateral Agent-Related Person and based on such documents and information as it has deemed appropriate, made its own appraisal of, and investigation into, the business, prospects, operations, property, financial and other condition and
creditworthiness of Borrower and its respective Subsidiaries, and all applicable bank or other regulatory laws relating to the transactions contemplated hereby, and made its own decision to enter into this Agreement and to extend credit to Borrower
hereunder. Each Lender also represents that it will, independently and without reliance upon any Collateral Agent-Related Person and based on such documents and information as it shall deem appropriate at the time, continue to make its own credit
analysis, appraisals and decisions in taking or not taking action under this Agreement and the other Loan Documents, and to make such investigations as it deems necessary to inform itself as to the business, prospects, operations, property,
financial and other condition and creditworthiness of Borrower. Except for notices, reports and other documents expressly required to be furnished to the Lenders by Collateral Agent herein, Collateral Agent shall not have any duty or responsibility
to provide any Lender with any credit or other information concerning the business, prospects, operations, property, financial and other condition or creditworthiness of Borrower or any of its Affiliates which may come into the possession of any
Collateral Agent-Related Person. 
 13.7        
Indemnification of Collateral Agent.     Whether or not the transactions contemplated hereby are consummated, each Lender shall, severally and pro rata based on its respective Pro Rata Share, indemnify upon demand each
Collateral Agent-Related Person (to the extent not reimbursed by or on behalf of Borrower and without limiting the obligation of Borrower to do so), and hold harmless each Collateral Agent-Related Person from and against any and all Claims (which
shall not include legal expenses of Collateral Agent incurred in connection with the closing of the transactions contemplated by this Agreement) incurred by it; provided, however, that no Lender shall be liable for the payment to any Collateral
Agent-Related Person of any portion of such Indemnified Liabilities to the extent determined in a judgment by a court of competent jurisdiction to have resulted from such Collateral Agent-Related Person’s own gross negligence or willful
misconduct; provided, however, that no action taken in accordance with the directions of the Required Lenders shall be deemed to constitute gross negligence or willful misconduct for purposes of this Section 13.7. Without limitation of the
foregoing, each Lender shall, severally and pro rata based on its respective Pro Rata Share, reimburse Collateral Agent upon demand for its ratable share of any costs or out-of-pocket expenses (including Lenders’ Expenses incurred after the
closing of the transactions contemplated by this Agreement) incurred by Collateral Agent (in its capacity as Collateral Agent, and not as a Lender) in connection with the preparation, execution, delivery, administration, modification, amendment or
enforcement (whether through negotiations, legal proceedings or otherwise) of, or legal advice in respect of rights or responsibilities under, this Agreement, any other Loan Document, or any document contemplated by or referred to herein, to the
extent that Collateral Agent is not reimbursed for such expenses by or on behalf of Borrower. The undertaking in this Section 13.7 shall survive the payment in full of the Obligations, the termination of this Agreement and the resignation of
Collateral Agent. 
 13.8         Collateral Agent in its
Individual Capacity.     With respect to its Credit Extensions, Oxford shall have the same rights and powers under this Agreement as any other Lender and may exercise such rights and powers as though it were not Collateral
Agent, and the terms “Lender” and “Lenders” include Oxford in its individual capacity. 

13.9         Successor Collateral Agent.
    Collateral Agent may resign as Collateral Agent upon ten (10) days’ notice to the Lenders. If Collateral Agent resigns under this Agreement, all Lenders shall appoint from among the Lenders (or the affiliates
thereof) a successor Collateral Agent for the Lenders, which successor Collateral Agent shall (unless an Event of Default has occurred and is continuing) be subject to the approval of Borrower (which approval shall not be unreasonably withheld or
delayed). If no successor Collateral Agent is appointed prior to the effective date of the resignation of Collateral Agent, Collateral Agent may appoint, after consulting with the Lenders, a successor Collateral Agent from among the Lenders (or the
affiliates thereof). Upon the acceptance of its appointment as successor Collateral Agent hereunder, the Person acting as such successor Collateral Agent shall succeed to all the rights, powers and duties of the retiring Collateral Agent and the
respective term “Collateral Agent” means such successor Collateral Agent and the retiring Collateral Agent’s appointment, powers and duties in such capacities shall be terminated without any other further act or deed on its behalf.
After any retiring Collateral Agent’s resignation hereunder as Collateral Agent, the provisions of this Article 13 and Sections 2.3(d) and 12.2 shall inure to its benefit as to any actions taken or omitted to be taken by it while it was
Collateral Agent under this Agreement. If no successor Collateral Agent has accepted appointment as Collateral Agent by the date ten (10) days following a retiring Collateral Agent’s notice of resignation, the retiring Collateral
Agent’s resignation shall nevertheless thereupon become effective and the Lenders shall perform all of the duties of Collateral Agent hereunder until such time, if any, as the Lenders appoint a successor agent as provided for above. 

  
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 13.10         Collateral
Agent May File Proofs of Claim.     In case of the pendency of any receivership, insolvency, liquidation, bankruptcy, reorganization, arrangement, adjustment, composition or other judicial proceeding relative to Borrower,
Collateral Agent (irrespective of whether the principal of any Loan, shall then be due and payable as herein expressed or by declaration or otherwise and irrespective of whether Collateral Agent shall have made any demand on Borrower) shall be
entitled and empowered, by intervention in such proceeding or otherwise: 
 (a)
        to file and prove a claim for the whole amount of the principal and interest owing and unpaid in respect of the Credit Extensions and all other Obligations that are owing and unpaid and to file such
other documents as may be necessary or advisable in order to have the claims of the Lenders and Collateral Agent (including any claim for the reasonable compensation, expenses, disbursements and advances of the Lenders and Collateral Agent and their
respective agents and counsel and all other amounts due the Lenders and Collateral Agent allowed in such judicial proceeding); and 
 (b)         to collect and receive any monies or other property payable or deliverable on any such claims and to distribute the same; 

and any custodian, receiver, assignee, trustee, liquidator, sequestrator or other similar official in any such judicial proceeding is
hereby authorized by each Lender to make such payments to Collateral Agent and, in the event that Collateral Agent shall consent to the making of such payments directly to the Lenders, to pay to Collateral Agent any amount due for the reasonable
compensation, expenses, disbursements and advances of Collateral Agent and its agents and counsel, and any other amounts due Collateral Agent under Section 2.3(d). To the extent that Collateral Agent fails timely to do so, each Lender may file
a claim relating to such Lender’s claim. 
 13.11        
Collateral and Guaranty Matters.     The Lenders irrevocably authorize Collateral Agent, at its option and in its discretion, to release any Guarantor and any Lien on any Collateral granted to or held by Collateral Agent
under any Loan Document (i) upon the date that all Obligations due hereunder have been fully and indefeasibly paid in full and no Term Loan Commitments or other obligations of any Lender to provide funds to Borrower under this Agreement remain
outstanding, (ii) that is transferred or to be transferred as part of or in connection with any Transfer permitted hereunder or under any other Loan Document, or (iii) as approved in accordance with Section 12.6. Upon request by
Collateral Agent at any time, all Lenders will confirm in writing Collateral Agent’s authority to release its interest in particular types or items of Property, pursuant to this Section 13.11. 

13.12         Cooperation of Borrower.     If
necessary, Borrower agrees to (i) execute any documents (including new Secured Promissory Notes) reasonably required to effectuate and acknowledge each assignment of a Term Loan Commitment or Loan to an assignee in accordance with
Section 12.1, (ii) make Borrower’s management available to meet with Collateral Agent and prospective participants and assignees of Term Loan Commitments or Credit Extensions (which meetings shall be conducted no more often than twice
every twelve months unless an Event of Default has occurred and is continuing) and (iii) assist Collateral Agent or the Lenders in the preparation of information relating to the financial affairs of Borrower as any prospective participant or
assignee of a Term Loan Commitment or Term Loan reasonably may request. Subject to the provisions of Section 12.9 Borrower authorizes each Lender to disclose to any prospective participant or assignee of a Term Loan Commitment, any and all
information in such Lender’s possession concerning Borrower and its financial affairs which has been delivered to such Lender by or on behalf of Borrower pursuant to this Agreement, or which has been delivered to such Lender by or on behalf of
Borrower in connection with such Lender’s credit evaluation of Borrower prior to entering into this Agreement. 
  

	 	 14
	 DEFINITIONS 

 14.1         Definitions.     As used in this Agreement, the following terms have the following meanings. In addition, unless
otherwise defined herein, (a) the following terms are used herein as defined in the PPSA as applicable: Accession, Account, Chattel 

  
 26 

 
Paper, Document of Title, Equipment, Goods, Intangible, Instrument, Inventory, Investment Property, Money, financing statement, and financing change statement, and (b) the following terms
have the meanings given to them in the STA: “Certificated Security”, “Entitlement Holder”, “Entitlement Order”, “Financial Asset”, “Issuer”, “Security”, “Securities Account”,
“Securities Intermediary”, “Security Entitlement”, and “Uncertificated Security”: 
 “Account” is any “account” as defined in the Code or PPSA, as applicable, with such additions to such term as may hereafter be made, and includes, without limitation, all
accounts receivable and other sums owing to Borrower. 
 “Account Debtor” is
any “account debtor” as defined or contemplated by in the Code or PPSA, as applicable, with such additions to such term as may hereafter be made. 

“Affiliate” of any Person is a Person that owns or controls directly or indirectly the
Person, any Person that controls or is controlled by or is under common control with the Person, and each of that Person’s senior executive officers, directors, partners and, for any Person that is a limited liability company, that
Person’s managers and members. 
 “Agreement” is defined in the preamble
hereof. 
 “Amortization Date” is, (i) with respect to
a Term A Loan, August 1, 2011, (ii) with respect to the Term B Loan , the seventh (7th) Payment Date following the Funding Date of Term B Loan and (ii) with respect to the Term C Loan , the seventh (7th) Payment Date following the Funding Date of Term C Loan. 

“Anti-Terrorism Laws” means any laws relating to terrorism or money laundering,
including Executive Order No. 13224 (effective September 24, 2001), the USA PATRIOT Act, the laws comprising or implementing the Bank Secrecy Act, and the laws administered by OFAC. 

“Approved Fund” means any (i) investment company, fund, trust, securitization
vehicle or conduit that is (or will be) engaged in making, purchasing, holding or otherwise investing in commercial loans and similar extensions of credit in the ordinary course of its business or (ii) any Person (other than a natural person)
which temporarily warehouses loans for any Lender or any entity described in the preceding clause (i) and that, with respect to each of the preceding clauses (i) and (ii), is administered or managed by (a) a Lender, (b) an
Affiliate of a Lender or (c) a Person (other than a natural person) or an Affiliate of a Person (other than a natural person) that administers or manages a Lender. 

“Approved Lender” has the meaning given it in Section 12.1. 

“Basic Rate” means with respect to a Term Loan, the per annum rate of interest (based on
a year of 360 days) equal to the greater of (i) 10.25% and (ii) the sum of (a) the 90-day U.S. LIBOR rate reported in the Wall Street Journal three (3) Business Days prior to the Funding Date of such Term Loan, plus
(b) 9.96%. 
 “Blocked Person” means any Person: (a) listed in the
annex to, or is otherwise subject to the provisions of, Executive Order No. 13224, (b) a Person owned or controlled by, or acting for or on behalf of, any Person that is listed in the annex to, or is otherwise subject to the provisions of,
Executive Order No. 13224, (c) a Person with which any Lender is prohibited from dealing or otherwise engaging in any transaction by any Anti-Terrorism Law, (d) a Person that commits, threatens or conspires to commit or supports
“terrorism” as defined in Executive Order No. 13224, or (e) a Person that is named a “specially designated national” or “blocked person” on the most current list published by OFAC or other similar list.

 “Borrower” is defined in the preamble hereof. 

“Borrower’s Books” are all Borrower’s books and records including ledgers,
federal, and state tax returns, records regarding Borrower’s assets or liabilities, the Collateral, business operations or financial condition, and all computer programs or storage or any equipment containing such information. 

  
 27 

 “Business Day” is any day that is not a
Saturday, Sunday or a day on which Collateral Agent is closed. 
 “Cash Burn”
is equal to the sum of the forecasted monthly net income/losses of Borrower, Guarantor and their respective Subsidiaries for each of the twenty-four (24) months following the date of determination. 

“Cash Equivalents” are (a) marketable direct obligations issued or unconditionally
guaranteed by the United States, the Government of Canada, or any agency or any State or Province thereof, as applicable, having maturities of not more than one (1) year from the date of acquisition; (b) commercial paper maturing no more
than one (1) year after its creation and having the highest rating from either Standard & Poor’s Ratings Group or Moody’s Investors Service, Inc., and (c) certificates of deposit maturing no more than one (1) year
after issue provided that the account in which any such certificate of deposit is maintained is subject to a Control Agreement in favor of Collateral Agent. For the avoidance of doubt, the direct purchase by Borrower, Guarantor, co-borrower, or any
subsidiary of Borrower or Guarantor of any Auction Rate Securities, or purchasing participations in, or entering into any type of swap or other derivative transaction, or otherwise holding or engaging in any ownership interest in any type of Auction
Rate Security by Borrower, Guarantor, co-borrower, or any subsidiary of Borrower or Guarantor shall be conclusively determined by the Lenders as an ineligible Cash Equivalent, and any such transaction shall expressly violate each other provision of
this agreement governing Permitted Investments. Notwithstanding the foregoing, Cash Equivalents does not include and Borrower, Guarantor, and their Subsidiaries are prohibited from purchasing, purchasing participations in, entering into any type of
swap or other equivalent derivative transaction, or otherwise holding or engaging in any ownership interest in any type of debt instrument, including, without limitation, any corporate or municipal bonds with a long-term nominal maturity for which
the interest rate is reset through a dutch auction and more commonly referred to as an auction rate security. 
 “Change in Control” means any event, transaction, or occurrence as a result of which (a) any “person” (as such term is defined in Sections 3(a)(9) and 13(d)(3) of the
Exchange Act), other than a trustee or other fiduciary holding securities under an employee benefit plan of Borrower, is or becomes a beneficial owner (within the meaning Rule 13d-3 promulgated under the Exchange Act), directly or indirectly, of
securities of Borrower, representing forty-nine percent (49%) or more of the combined voting power of Borrower’s then outstanding securities; or (b) during any period of twelve consecutive calendar months, individuals who at the
beginning of such period constituted the Board of Directors of Borrower (together with any new directors whose election by the Board of Directors of Borrower was approved by a vote of not less than two-thirds of the directors then still in office
who either were directions at the beginning of such period or whose election or nomination for election was previously so approved) cease for any reason other than death or disability to constitute a majority of the directors then in office.

 “Claims” are defined in Section 12.2. 

“Code” is the Uniform Commercial Code, as the same may, from time to time, be enacted
and in effect in the State of New York; provided, that, to the extent that the Code is used to define any term herein or in any Loan Document and such term is defined differently in different Articles or Divisions of the Code, the definition of such
term contained in Article or Division 9 shall govern; provided further, that in the event that, by reason of mandatory provisions of law, any or all of the attachment, perfection, or priority of, or remedies with respect to, Collateral Agent’s
Lien on any Collateral is governed by the Uniform Commercial Code in effect in a jurisdiction other than the State of New York, the term “Code” shall mean the Uniform Commercial Code as enacted and in effect in such other jurisdiction
solely for purposes of the provisions thereof relating to such attachment, perfection, priority, or remedies and for purposes of definitions relating to such provisions. 

“Collateral” is any and all properties, rights and assets of Borrower and/or Guarantor
described on Exhibit A and any and all other properties, rights and assets of Borrower and/or Guarantor granted by Borrower and/or Guarantor to Collateral Agent for the ratable benefit of the Lenders or arising under the Code or PPSA,
as applicable, or other applicable law, now, or in the future. 
 “Collateral
Account” is any Deposit Account, Securities Account, or Commodity Account. 

  
 28 

 “Collateral Agent” means, Oxford, not in
its individual capacity, but solely in its capacity as agent on behalf of and for the benefit of the Lenders. 
 “Collateral Agent-Related Person” means the Collateral Agent, together with its Affiliates, and the officers, directors, employees, agents, advisors, auditors and attorneys-in-fact of
such Persons; provided, however, that no Collateral Agent-Related Person shall be an Affiliate of Borrower or Guarantor . 
 “Commitment Percentage” is set forth in Schedule 1.1, as amended from time to time. 

“Commodity Account” is any “commodity account” as defined in the Code with
such additions to such term as may hereafter be made. 
 “Communication” is
defined in Section 10. 
 “Compliance Certificate” is that certain
certificate in the form attached hereto as Exhibit C. 
 “Contingent
Obligation” is, for any Person, any direct or indirect liability, contingent or not, of that Person for (a) any indebtedness, lease, dividend, letter of credit or other obligation of another such as an obligation directly or indirectly
guaranteed, endorsed, co-made, discounted or sold with recourse by that Person, or for which that Person is directly or indirectly liable; (b) any obligations for undrawn letters of credit for the account of that Person; and (c) all
obligations from any interest rate, currency or commodity swap agreement, interest rate cap or collar agreement, or other agreement or arrangement designated to protect a Person against fluctuation in interest rates, currency exchange rates or
commodity prices; but “Contingent Obligation” does not include endorsements in the ordinary course of business. The amount of a Contingent Obligation is the stated or determined amount of the primary obligation for which the Contingent
Obligation is made or, if not determinable, the maximum reasonably anticipated liability for it determined by the Person in good faith; but the amount may not exceed the maximum of the obligations under any guarantee or other support arrangement.

 “Control Agreement” is any control agreement entered into among (a) the
depository institution at which Borrower or Guarantor maintains a Deposit Account or the securities intermediary or commodity intermediary at which Borrower or Guarantor maintains a Securities Account or a Commodity Account, (b) Borrower or
Guarantor, and (c) Collateral Agent pursuant to which Collateral Agent obtains control (within the meaning of the Code or STA, as applicable) for the benefit of the Lenders over such Deposit Account, Securities Account, or Commodity Account.

 “Credit Extension” is any Term Loan or any other extension of credit by
Collateral Agent or Lenders for Borrower’s benefit. 
 “Default Rate” is
defined in Section 2.3(b). 
 “Deposit Account” is any “deposit
account” as defined in the Code with such additions to such term as may hereafter be made. 

“Designated Deposit Account” is Borrower’s primary deposit account, maintained with
Bank of America N.A., or such other account as may be used from time to time with the written consent of both parties. 
 “Dollars,” “dollars” and “$” each mean lawful money of the United States. 

“Effective Date” is defined in the preamble of this Agreement. 

“Eligible Assignee” means (i) a Lender, (ii) an Affiliate of a Lender,
(iii) an Approved Fund and (iv) any commercial bank, savings and loan association or savings bank or any other entity which is an “accredited investor” (as defined in Regulation D under the Securities Act of 1933, as amended) and
which extends credit or buys loans as one of its businesses, including insurance companies, mutual funds, lease financing companies and commercial finance companies, in each case, 

  
 29 

 
which either (A) has a rating of BBB or higher from Standard & Poor’s Rating Group and a rating of Baa2 or higher from Moody’s Investors Service, Inc. at the date that it
becomes a Lender or (B) has total assets in excess of $5,000,000,000, and in each case of clauses (i) through (iv), which, through its applicable lending office, is capable of lending to Borrower without the imposition of any withholding
or similar taxes; provided that notwithstanding the foregoing, “Eligible Assignee” shall not include (i) Borrower, Guarantor or any of Borrower’s or Guarantor’s Affiliates or Subsidiaries or (ii) unless an Event of
Default has occurred and is continuing, a direct competitor of Borrower or Guarantor or a vulture hedge fund, each as determined by Collateral Agent. Notwithstanding the foregoing, in connection with assignments by a Lender due to a forced
divestiture at the request of any regulatory agency, the restrictions set forth herein shall not apply and Eligible Assignee shall mean any Person or party. 

“Equipment” is all “equipment” as defined in the Code or PPSA, as applicable,
with such additions to such term as may hereafter be made, and includes without limitation all machinery, fixtures, goods, vehicles (including motor vehicles and trailers), and any interest in any of the foregoing. 

“ERISA” is the Employee Retirement Income Security Act of 1974, as amended, and its
regulations. 
 “Event of Default” is defined in Section 8. 

“Exalgo Agreements” means collectively, (i) the Asset Purchase Agreement dated as
of June 11, 2009 between Zalicus-Canada (as successor to Neuromed Development Inc.) and Mallinckrodt Inc., as amended by the First Amendment to Asset Purchase Agreement dated as of July 15, 2009, and (ii) the Assignment and Assumption
Agreement dated as of June 11, 2009 between Zalicus-Canada (as successor to Neuromed Development Inc.) and Mallinckrodt Inc. [Others?] 
 “Final Payment” is a payment (in addition to and not a substitution for the regular monthly payments of principal plus accrued interest) due on the earliest to occur of (a) the
Maturity Date, or (b) the acceleration of any Term Loan, or (c) the prepayment of a Term Loan pursuant to Section 2.2(c) or (d), equal to the original principal amount of such Term Loan multiplied by the Final Payment Percentage,
payable to Lenders in accordance with their respective Pro Rata Shares. 
 “Final
Payment Percentage” is one and one-half percent (1.50%). 
 “Funding
Date” is any date on which a Credit Extension is made to or on account of Borrower which shall be a Business Day. 
 “GAAP” is generally accepted accounting principles set forth in the opinions and pronouncements of the Accounting Principles Board of the American Institute of Certified Public
Accountants and statements and pronouncements of the Financial Accounting Standards Board or in such other statements by such other Person as may be approved by a significant segment of the accounting profession in the United States, which are
applicable to the circumstances as of the date of determination. 
 “General
Intangibles” is all “general intangibles” as defined in the Code and “intangibles” as defined in the PPSA, as applicable, in effect on the date hereof with such additions to such term as may hereafter be made, and
includes without limitation, all copyright rights, copyright applications, copyright registrations and like protections in each work of authorship and derivative work, whether published or unpublished, any patents, trademarks, service marks and, to
the extent permitted under applicable law, any applications therefor, whether registered or not, any trade secret rights, including any rights to unpatented inventions, payment intangibles, royalties, contract rights, goodwill, franchise agreements,
purchase orders, customer lists, route lists, telephone numbers, domain names, claims, income and other tax refunds, security and other deposits, options to purchase or sell real or personal property, rights in all litigation presently or hereafter
pending (whether in contract, tort or otherwise), insurance policies (including without limitation key man, property damage, and business interruption insurance), payments of insurance and rights to payment of any kind. 

  
 30 

 “Governmental Approval” is any consent,
authorization, approval, order, license, franchise, permit, certificate, accreditation, registration, filing or notice, of, issued by, from or to, or other act by or in respect of, any Governmental Authority. 

“Governmental Authority” is any nation or government, any state or other political
subdivision thereof, any agency, authority, instrumentality, regulatory body, court, central bank or other entity exercising executive, legislative, judicial, taxing, regulatory or administrative functions of or pertaining to government, any
securities exchange and any self-regulatory organization. 
 “Guarantor” is any
present or future guarantor of the Obligations. 
 “Indebtedness” is
(a) indebtedness for borrowed money or the deferred price of property or services, such as reimbursement and other obligations for surety bonds and letters of credit, (b) obligations evidenced by notes, bonds, debentures or similar
instruments, (c) capital lease obligations, and (d) Contingent Obligations. 

“Indemnified Person” is defined in Section 12.2. 

“Insolvency Proceeding” is any proceeding by or against any Person under the United
States Bankruptcy Code, (b) the Bankruptcy and Insolvency Act (Canada) or the Companies’ Creditors Arrangement Act (Canada) or (c) or any other bankruptcy or insolvency law, including assignments for the benefit of creditors,
compositions, extensions generally with its creditors, or proceedings seeking reorganization, arrangement, or other relief. 
 “Intellectual Property” includes without limitation, all copyright rights, copyright applications, copyright registrations and like protections in each work of authorship and derivative
work, whether published or unpublished, any patents, patent applications and like protections, including improvements, divisions, continuations, renewals, reissues, extensions, and continuations-in-part of the same, trademarks, trade names, service
marks, mask works, rights of use of any name, domain names, or any other similar rights, any applications therefor, whether registered or not, and the goodwill of the business of any Person connected with and symbolized thereby, know-how, operating
manuals, trade secret rights, clinical and non-clinical data, rights to unpatented inventions, and any claims for damage by way of any past, present, or future infringement of any of the foregoing. 

“Inventory” is all “inventory” as defined in the Code or PPSA, as applicable,
in effect on the date hereof with such additions to such term as may hereafter be made, and includes without limitation all merchandise, raw materials, parts, supplies, packing and shipping materials, work in process and finished products, including
without limitation such inventory as is temporarily out of any Person’s custody or possession or in transit and including any returned goods and any documents of title representing any of the above. 

“Investment” is any beneficial ownership interest in any Person (including stock,
partnership interest or other securities), and any loan, advance or capital contribution to any Person. 
 “Key Person” means each of Borrower’s (i) President and Chief Executive Officer, who is Mark Corrigan as of the Effective Date and (ii) Chief Financial Officer, who is
Justin Renz as of the Effective Date. 
 “Lender” is any one of the Lenders.

 “Lenders” shall mean the Persons identified on Schedule 1.1 hereto and each
assignee that becomes a party to this Agreement pursuant to Section 12.1. 

“Lenders’ Expenses” are all audit fees and expenses, costs, and expenses (including
reasonable attorneys’ fees and expenses, as well as appraisal fees, fees incurred on account of lien searches, inspection fees, and filing fees) for preparing, amending, negotiating, administering, defending and enforcing the Loan Documents
(including, without limitation, those incurred in connection with appeals or Insolvency Proceedings) or otherwise incurred by Collateral Agent and/or the Lenders in connection with the Loan Documents. 

  
 31 

 “Lien” is a claim, mortgage, deed of trust,
levy, charge, pledge, security interest, or other encumbrance of any kind, whether voluntarily incurred or arising by operation of law or otherwise against any property. 

“Loan Documents” are, collectively, this Agreement, the Warrants, the Perfection
Certificate, each Compliance Certificate, any subordination agreements, any note, or notes or guaranties executed by Borrower, and any other present or future agreement between Borrower and/or Guarantor for the benefit of Lenders and Collateral
Agent in connection with this Agreement, all as amended, restated, or otherwise modified. 

“Material Adverse Change” is (a) a material impairment in the perfection or
priority of Collateral Agent’s Lien in the Collateral or in the value of such Collateral; (b) a material adverse change in the business, operations, or condition (financial or otherwise) of Borrower or Guarantor; or (c) a material
impairment of the prospect of repayment of any portion of the Obligations. 
 “Maturity
Date” is, for each Term Loan, the date which is Thirty-five (35) months after the Amortization Date with respect to such Term Loan. 

“Obligations” are Borrower’s obligation to pay when due any debts, principal,
interest, Lenders’ Expenses, the Prepayment Fee, the Final Payment, and other amounts Borrower owes the Lenders now or later, whether under this Agreement, the Loan Documents (other than the Warrants), or otherwise, including, without
limitation, all obligations relating to letters of credit (including reimbursement obligations for drawn and undrawn letters of credit), cash management services, and foreign exchange contracts, if any, and including interest accruing after
Insolvency Proceedings begin (whether or not allowed) and debts, liabilities, or obligations of Borrower assigned to the Lenders and/or Collateral Agent, and the performance of Borrower’s duties under the Loan Documents (other than the
Warrants). 
 “OFAC” is the U.S. Department of Treasury Office of Foreign
Assets Control. 
 “OFAC Lists” are, collectively, the Specially Designated
Nationals and Blocked Persons List maintained by OFAC pursuant to Executive Order No. 13224, 66 Fed. Reg. 49079 (Sept. 25, 2001) and/or any other list of terrorists or other restricted Persons maintained pursuant to any of the rules and
regulations of OFAC or pursuant to any other applicable Executive Orders. 

“Operating Documents” are, for any Person, such Person’s formation
documents, as certified by the Secretary of State or Registrar of Companies, as applicable, of such Person’s jurisdiction of organization on a date that is no earlier than 30 days prior to the Effective Date, and, (a) if such Person is a
corporation, its bylaws in current form, (b) if such Person is a limited liability company, its limited liability company agreement (or similar agreement), and (c) if such Person is a partnership, its partnership agreement (or similar
agreement), each of the foregoing with all current amendments or modifications thereto. 

“Payment/Advance Form” is that certain form attached hereto as Exhibit B.

 “Payment Date” is the first (1st) calendar day of each calendar month. 

“Perfection Certificate” is defined in Section 5.1. 

“Permitted Acquisition” means an acquisition by Borrower of capital stock or property of
any Person which results in such stock or property being owned by Borrower following the closing of such transaction, provided that: (a) Borrower has provided the Lenders with no less than thirty (30) days notice prior to the closing of
such transaction, including without limitation, the name of the Person being acquired by Borrower or a summary description of the assets being acquired by Borrower, the total consideration for the transaction (broken out into line items for cash and
other property), the form of the transaction (asset purchase, stock purchase or otherwise) and any other information reasonably requested by the Lenders; (b) the Person being acquired operates in the pharmaceutical, biopharmaceutical, or
biotechnology industry; (c) the consideration paid by Borrower in any such transaction is in the form of the capital stock of Borrower or cash (provided that the cash consideration 

  
 32 

 
(including any earn-outs or deferred payments) paid by Borrower shall not exceed $5,000,000 in the aggregate for all such Permitted Acquisitions); (d) before and after giving effect to the
consummation of the transaction, no Event of Default has occurred and is continuing or could not reasonably be expected to result from such transaction; (e) the assets of the target company in such acquisition are free and clear of all Liens
that would not otherwise constitute Permitted Liens hereunder at the time of the closing of such transaction; (f) Borrower (or a Subsidiary of Borrower provided that such Subsidiary complies with the provisions of Section 6.10 hereof) is
the surviving corporation of any such transaction, (g) Borrower delivers to the Lenders, within thirty (30) days of the closing of any such transaction, any documents required by the Lenders in order for the Lenders to obtain a first
priority security interest in the assets acquired by Borrower (including, without limitation, assets owned by a Subsidiary with respect to which Borrower has acquired all or a portion of such entity’s stock) subject only to Permitted
Liens, (h) Borrower shall comply with the provisions of Section 6.10 hereof with respect to any Person acquired in any such transaction, (i) Borrower delivers to the Lenders, within thirty (30) days of the closing of any such
transaction, projections, in form and substance reasonably acceptable to Lenders, projecting that such transaction will not increase the projected net losses associated with the Cash Burn of Borrower, Guarantor and their Subsidiaries (after giving
pro forma effect for such transaction), (j) Borrower’s board of directors has approved the transaction, (k) in the event the transaction involves the acquisition of capital stock of a Person, Borrower or one of its Subsidiaries
acquires a majority of the capital stock of such Person and (l) after giving effect to the transaction there is no Change in Control.
 “Permitted Indebtedness” is: 

(a)         Borrower’s and Guarantor’s Indebtedness to
the Lenders and Collateral Agent under this Agreement and the other Loan Documents; 
 (b)
        Indebtedness existing on the Effective Date and shown on the Perfection Certificate; 
 (c)         Subordinated Debt; 
 (d)         unsecured Indebtedness to trade creditors incurred in the ordinary course of business; 

(e)         Indebtedness secured by liens specified in clause
(c) of the definition of “Permitted Liens” provided such Indebtedness shall not exceed Two Million Dollars ($2,000,000) in the aggregate principal amount outstanding at any one time; 

(f)         Indebtedness incurred as a result of endorsing
negotiable instruments received in the ordinary course of Borrower’s business; 
 (g)
        Indebtedness consisting of interest rate, currency or commodity swap agreements, interest rate cap or collar agreements or arrangements entered into in the ordinary course of business and not for
speculative purposes and designed to protect Borrower or Guarantor or their Subsidiaries against fluctuations in interest rates, currency exchange rates, or commodity prices; 

(h)         Indebtedness incurred as a result of endorsing
negotiable instruments received in the ordinary course of business; 
 (i)
        earn-out obligations or deferred payments of consideration in connection with Permitted Acquisition to the extent permitted by the definition of “Permitted Acquisition”; 

(j)         guarantees of Permitted Indebtedness; 

(k)         other Indebtedness in aggregate amount outstanding
not to exceed One Hundred Fifty Thousand Dollars ($150,000) at any time; and 

  
 33 

 (l)
        extensions, refinancings, modifications, amendments and restatements of any items of Permitted Indebtedness (a) through (k) above, provided that the principal amount thereof is not increased
or the terms thereof are not modified to impose materially more burdensome terms upon Borrower, Guarantor or its Subsidiary, as the case may be. 

“Permitted Intellectual Property Licenses” are: (i) non-exclusive licenses of
Intellectual Property granted to third parties in the ordinary course of business, (ii) licenses of Intellectual Property that could not result in a legal transfer of title of the licensed property but that may be exclusive or non-exclusive
with respect to territory, field(s) of use, rights to research, develop, commercialize, manufacture, market and/or distribute, and (iii) exclusive or non-exclusive licenses, assignments or other conveyance of rights to Intellectual Property
directly related to specific neuronal Ion channels and/or compounds interacting with such neuronal Ion channels. 
 “Permitted Investments” are: 

(a)         Investments shown on the Perfection Certificate and
existing on the Effective Date; and 
 (b)
        Investments permitted by Borrower’s or Guarantor’s investment policy as approved by Collateral Agent and the Lenders, as amended from time to time with the approval of the Collateral Agent
and the Lenders; 
 (c)         Investments consisting
of extensions of credit to customers of Borrower, Guarantor or their respective Subsidiaries in the nature of accounts receivable, prepaid royalties or notes receivable in the ordinary course of business arising from the sale or lease of goods,
provision of services or licensing activities; 
 (d)
        Investments received in connection with settlements with or the bankruptcy or reorganization of customers or suppliers; 

(e)         joint ventures or strategic alliances in the ordinary
course of Borrower’s or Guarantor’s business consisting of the non-exclusive licensing of technology, the development of technology or the providing of technical support, provided that any cash investments by Borrower or Guarantor do not
exceed $100,000 in any fiscal year; 
 (f)
        Investments consisting of interest rate, currency or commodity swap agreements, interest rate cap or collar agreements or arrangements entered into in the ordinary course of business and not for
speculative purposes and designed to protect Borrower or Guarantor or their Subsidiaries against fluctuations in interest rates, currency exchange rates, or commodity prices; 

(g)         Investments consisting of travel advances, employee
relocation loans and other employee loans and advances in the ordinary course of business in an amount not to exceed One Hundred Thousand Dollars ($100,000) in any fiscal year; 

(h)         Cash and Cash Equivalents; and 

(h)         other Investments in an amount not to exceed One
Hundred Fifty Thousand Dollars ($150,000) at any time. 
 “Permitted Liens”
are: 
 (a)         Liens existing on the Effective Date
and shown on the Perfection Certificate or arising under this Agreement and the other Loan Documents; 
 (b)         Liens for taxes, fees, assessments or other government charges or levies, either not delinquent or being contested in good faith and for which Borrower
or Guarantor maintains adequate reserves on its Books, provided that no notice of any such Lien has been filed or recorded under the Internal Revenue Code of 1986, as amended , and the Treasury Regulations adopted thereunder; 

  
 34 

 (c)         Liens
(i) on Equipment or other assets subject to capital leases acquired or held by Borrower or Guarantor incurred for financing the acquisition of the Equipment or such assets subject to capital leases, or (ii) on existing Equipment or such
assets subject to capital leases when acquired, in each case if the Lien is confined to the property and improvements and the proceeds of the Equipment or other assets subject to capital leases; provided that such Liens under this clause
(c) (A) may have priority over liens granted to Collateral Agent hereunder to the extent provided under the Code or the PPSA, as applicable, so long as the Indebtedness secured by the Liens remain outstanding and (B) may secure
Indebtedness of no more than Two Million Dollars ($2,000,000) in the aggregate principal amount outstanding at any one time; 
 (d)         statutory Liens securing claims or demands of materialmen, mechanics, carriers, warehousemen, landlords and other Persons imposed without action of such
parties, provided they have no priority over any of Collateral Agent’s Lien and the aggregate amount of the obligations secured by such Liens does not any time exceed Fifty Thousand Dollars ($50,000); 

(e)         leases or subleases of real property granted in the
ordinary course of business, and leases, subleases, non-exclusive licenses or sublicenses of property (other than real property or Intellectual Property) granted in the ordinary course of Borrower’s or Guarantor’s business, if the
leases, subleases, licenses and sublicenses do not prohibit granting Collateral Agent a security interest; and 
 (f)         banker’s liens, rights of setoff and Liens in favor of financial institutions incurred made in the ordinary course of business arising in
connection with Borrower’s or Guarantor’s deposit accounts or securities accounts held at such institutions to secure solely payment of fees and similar costs and expenses and provided such accounts are maintained in compliance with
Section 6.6(b) hereof; 
 (g)         Liens to
secure payment of workers’ compensation, employment insurance, social security and other like obligations incurred in the ordinary course of business (other than Liens imposed by ERISA or any Canadian employee benefit or pension plan);

 (h)         Liens arising from judgments, decrees or
attachments in circumstances not constituting an Event of Default under Section 8.4 or 8.7; 
 (i)         licenses of Intellectual Property permitted by Section 7.1 hereof; 

(j)         Liens on insurance proceeds in favor of insurance
companies granted solely to secure financed insurance premiums; 
 (k)
        Liens incurred in the extension, renewal or refinancing of the indebtedness secured by Liens described in (a) and (c) above, but any extension, renewal or replacement Lien must be
limited to the property encumbered by the existing Lien and the principal amount of the Indebtedness may not increase; and 
 (l)         Liens existing at the time that a Person becomes a Subsidiary of Borrower or any of its Subsidiaries as part of a Permitted Acquisition provided such
Liens constitute “Permitted Liens” hereunder; 
 “Person” is any
individual, sole proprietorship, partnership, limited liability company, joint venture, company, trust, unincorporated organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or
government agency. 
 “PPSA” the Personal Property Security Act (British
Columbia), including the regulations thereto, provided that, if perfection or the effect of perfection or non-perfection or the priority of any Lien created hereunder on the Collateral is governed by the personal property security legislation or
other applicable legislation with respect to personal property security in effect in a jurisdiction other than British Columbia, “PPSA” means the Personal Property Security Act or such other applicable legislation in effect from
time to time in such other jurisdiction for purposes of the provisions hereof relating to such perfection, effect of perfection or non-perfection or priority. References to “PPSA” include where applicable, provisions and definitions of the
STA. 

  
 35 

 “Prepayment Fee” means with respect to any
Term Loan subject to prepayment prior to the Maturity Date, whether by mandatory or voluntary prepayment, acceleration or otherwise, an additional fee payable to the Lenders in amount equal to: 

 

	 	 (i)
	 for a prepayment made on or after the Funding Date of such Term Loan through and including the first anniversary of the Funding Date of such Term
Loan, four percent (4.00%) of the principal amount of such Term Loan prepaid; 

  

	 	 (ii)
	 for a prepayment made after the date which is after the first anniversary of the Funding Date of such Term Loan through and including the second
anniversary of the Funding Date of such Term Loan, two percent (2.00%) of the principal amount of the Term Loans prepaid; and 

  

	 	 (iii)
	 for a prepayment made after the date which is after the second anniversary of the Funding Date of such Term Loan but prior to the Maturity Date of
such Term Loan, one percent (1.00%) of the principal amount of the Term Loans prepaid. 

 “Pro Rata Share” means, as of any date of determination, with respect to each Lender, a percentage (expressed as a decimal, rounded to the ninth decimal place) determined by dividing the
outstanding principal amount of Term Loans held by such Lender by the aggregate outstanding principal amount of all Term Loans. 
 “Registered Organization” is any “registered organization” as defined in the Code with such additions to such term as may hereafter be made, or as applicable, any
“corporation” or partnership as defined or contemplated in the Business Corporations Act (British Columbia). 
 “Required Lenders” means (i) for so long as all of the Persons that are Lenders on the Effective Date (each an “Original Lender”) have not assigned or transferred
any of their interests in their respective Term Loans, Lenders holding one hundred percent (100%) of the aggregate outstanding principal balance of the Term Loans, or (ii) at any time from and after any Original Lender has assigned or
transferred any interest in its Term Loans, Lenders holding, sixty-six percent (66%) or more of the aggregate outstanding principal balance of the Term Loans, plus, in respect of this clause (ii), (A) each Original Lender that has
not assigned or transferred any portion of its respective Term Loan and (B) each assignee of an Original Lender provided such assignee was assigned or transferred and continues to hold 100% of the assigning Original Lender’s interest in
the Term Loans (in each case in respect of clauses (A) and (B) of this clause (ii), whether or not such Lender is included within the Lenders holding sixty-six percent (66%) of the Terms Loans); provided, however, that
notwithstanding the foregoing, for purposes of Section 9.1(b) hereof, “Required Lenders” means (i) for so long as all Original Lenders retain 100% of their interests in their respective Term Loans, Lenders holding one hundred
percent (100%) of the aggregate outstanding principal balance of the Term Loans, or (ii) at any time from and after any Original Lender has assigned or transferred any interest in its Term Loans, Lenders holding, sixty-six percent
(66%) or more of the aggregate outstanding principal balance of the Term Loans, plus, in respect of this clause (ii), each Original Lender that has not assigned or transferred any portion of its respective Term Loan (in each case in respect of
this clause (ii), whether or not such Original Lender is included within the Lenders holding sixty-six percent (66%) of the Term Loans). For purposes of this definition only, a Lender shall be deemed to include itself, and any Lender that is an
Affiliate or Approved Fund of such Lender. 
 “Requirement of Law” is as to any
Person, the organizational or governing documents of such Person, and any law (statutory or common), treaty, rule or regulation or determination of an arbitrator or a court or other Governmental Authority, in each case applicable to or binding upon
such Person or any of its property or to which such Person or any of its property is subject. 

“Responsible Officer” is any of the President, Chief Executive Officer, or Chief
Financial Officer of Borrower acting alone. 

  
 36 

 “Second Draw Period” means the period
commencing on the Effective Date and ending on the earlier of (i) July 15, 2011 and (ii) the occurrence of an Event of Default. 
 “Secured Promissory Note” is defined in Section 2.4. 
 “Secured Promissory Note Record” is a record maintained by each Lender with respect to the outstanding Obligations owed by Borrower to Lender and credits made thereto. 

“Securities Account” is any “securities account” as defined in the Code or the
PPSA, as applicable, with such additions to such term as may hereafter be made. 

“STA” means the Securities Transfer Act (British Columbia), including the
regulations thereto, provided that, to the extent that perfection or the effect of perfection or non-perfection or the priority of any Lien created hereunder on Collateral that is Investment Property is governed by the laws in effect in any province
or territory of Canada other than British Columbia in which there is in force legislation substantially the same as the Securities Transfer Act, 2007 (British Columbia) (an “Other STA Province”), then “STA” shall
mean such other legislation as in effect from time to time in such Other STA Province for purposes of the provisions hereof referring to or incorporating by reference provisions of the STA; 

“Subordinated Debt” is indebtedness incurred by Borrower or Guarantor subordinated to
all of Borrower’s or Guarantor’s now or hereafter indebtedness to the Lenders (pursuant to a subordination, intercreditor, or other similar agreement in form and substance satisfactory to Collateral Agent and the Lenders entered into
between Collateral Agent, Borrower, and the other creditor), on terms acceptable to Collateral Agent and the Lenders. 
 “Subsidiary” means, with respect to any Person, any Person of which more than 50.0% of the voting stock or other equity interests (in the case of Persons other than corporations) is owned
or controlled, directly or indirectly, by such Person or one or more of Affiliates of such Person. 
 “Term Loan” is defined in Section 2.2(a)(ii) hereof. 
 “Term A Loan” is defined in Section 2.2(a)(i) hereof. 
 “Term B Loan” is defined in Section 2.2(a)(ii) hereof. 
 “Term C Loan” is defined in Section 2.2(a)(iii) hereof. 
 “Term Loan Commitment” means, for any Lender, the obligation of such Lender to make a Term Loan, up to the principal amount shown on Schedule 1.1. “Term Loan
Commitments” means the aggregate amount of such commitments of all Lenders. 

“Third Draw Period” means the period commencing on the Effective Date and ending on the
earlier of (i) January 15, 2012 and (ii) the occurrence of an Event of Default. 

“Transfer” is defined in Section 7.1. 

“Warrants” are those certain Warrants to Purchase Stock dated as of the Effective Date
executed by Borrower in favor of Lenders. 
 [Signature Page to Follow] 

  
 37 

 IN WITNESS WHEREOF, the parties hereto have caused this Agreement to
be executed as of the Effective Date. 
 BORROWER: 

ZALICUS INC. 
 By /s/ Mark H. N. Corrigan 
 Name:   Mark H. N. Corrigan

 Title:   President and Chief Executive Officer 

ZALICUS PHARMACEUTICALS LTD. 
 By /s/ Mark H. N. Corrigan 
 Name:   Mark H. N. Corrigan

 Title:   President and Chief Executive Officer 

COLLATERAL AGENT AND LENDER: 
 OXFORD FINANCE CORPORATION, as Collateral Agent and as a Lender 
 By /s/
John Hendersen 
 Name:   John Hendersen 

Title:   Senior Vice President and General Counsel  

 
  
  

[Signature Page to Loan and Security Agreement] 

 SCHEDULE 1.1 

LENDERS AND COMMITMENTS 
 Term A Loans 

					
	Lender	  	Term Loan Commitment	  	Commitment
Percentage
	 Oxford
Finance Corporation
	  	$3,000,000	  	100.00%
	
TOTAL
	  	$3,000,000	  	100.00%

Term B Loans 

					
	Lender	  	Term Loan Commitment	  	Commitment
Percentage
	 Oxford
Finance Corporation
	  	$8,500,000	  	100.00%
	
TOTAL
	  	$8,500,000	  	100.00%

Term C Loans 

					
	Lender	  	Term Loan Commitment	  	Commitment
Percentage
	 Oxford
Finance Corporation
	  	$8,500,000	  	100.00%
	
TOTAL
	  	$8,500,000	  	100.00%

Aggregate (all Term Loans) 

					
	Lender	  	Term Loan Commitment	  	Commitment
Percentage
	 Oxford
Finance Corporation
	  	$20,000,000	  	100.00%
	
TOTAL
	  	$20,000,000	  	100.00%

 EXHIBIT A 

The Collateral consists of all of Borrower’s and/or Guarantor’s right, title and interest in and to the following personal
property: 
 All goods, Accounts (including health-care receivables), Equipment, Inventory, contract rights or
rights to payment of money, leases, license agreements, franchise agreements, General Intangibles (except as provided below), commercial tort claims, documents, instruments (including any promissory notes), chattel paper (whether tangible or
electronic), cash, deposit accounts, all certificates of deposit, fixtures, letters of credit rights (whether or not the letter of credit is evidenced by a writing), securities, and all other investment property, supporting obligations, and
financial assets, whether now owned or hereafter acquired, wherever located; and 
 All Borrower’s Books
relating to the foregoing, and any and all claims, rights and interests in any of the above and all substitutions for, additions, attachments, accessories, accessions and improvements to and replacements, products, proceeds and insurance proceeds of
any or all of the foregoing. 
 Notwithstanding the foregoing, the Collateral does not include any of the
following, whether now owned or hereafter acquired except to the extent that it is necessary under applicable law to have a security interest in any of the following in order to have a perfected lien and security interest in and to the “IP
Proceeds” defined below: any copyright rights, copyright applications, copyright registrations and like protections in each work of authorship and derivative work, whether published or unpublished; any patents, patent applications and like
protections, including improvements, divisions, continuations, renewals, reissues, extensions, and continuations-in-part of the same; trademarks, trade names, service marks, mask works, rights of use of any name or domain names and, to the extent
permitted under applicable law, any applications therefor, whether registered or not; and the goodwill of the business of Borrower and/or Guarantor connected with and symbolized thereby, know-how, operating manuals, trade secret rights, clinical and
non-clinical data, rights to unpatented inventions; provided, however, the Collateral shall include all Accounts, license and royalty fees and other revenues, proceeds, or income arising out of or relating to any of the foregoing and any claims for
damage by way of any past, present, or future infringement of any of the foregoing (collectively, the “IP Proceeds”). 

 EXHIBIT B 
 Loan Payment/Advance Request Form 
 DISBURSEMENT LETTER

 The undersigned, being the duly elected and acting
                         of Zalicus Inc., a Delaware corporation with offices located at 245 First Street,
Third Floor, Cambridge, MA 02459 (“Borrower”), does hereby certify to OXFORD FINANCE CORPORATION, (“Oxford” and “Lender”), as collateral agent (the “Collateral Agent”) in
connection with that certain Loan and Security Agreement dated as of December __, 2010, by and between Borrower and Collateral Agent (the “Loan Agreement”; with other capitalized terms used below having the meanings ascribed thereto in the
Loan Agreement) that: 
 1.         The representations and warranties
made by Borrower and Guarantor in Section 5 of the Loan Agreement and in the other Loan Documents are true and correct in all material respects as of the date hereof. 

2.         No event or condition has occurred and is continuing that would
constitute an Event of Default under the Loan Agreement or any other Loan Document. 
 3.
        Borrower and Guarantor are in compliance with the covenants and requirements contained in Sections 4, 6 and 7 of the Loan Agreement. 

4.         All conditions referred to in Section 3 of the Loan
Agreement to the making of the Loan to be made on or about the date hereof have been satisfied or waived by Collateral Agent. 
 5.         No Material Adverse Change has occurred. 
 6.         The undersigned is a Responsible Officer. 
 7.         The proceeds for the Term Loan shall be disbursed as follows: 
 Disbursement from Collateral Agent: 

            Loan Amount
                                         
                $                 

            Plus: 

            --Deposit Received
                                    ($
                ) 

            Less: 

            --Lender’s Legal Fees
                                ($     
            ) 

            --Facility Fee
                                ($    
            ) 
 Net Proceeds due from
Collateral Agent:         $                 

 The aggregate net proceeds of the Term Loan in the amount of
$                 shall be transferred to Borrower’s account as follows: 
  

									
	 Account Name:
	  	 	  		  		  	
	 Bank Name:
	  	 	  		  		  	
	 Bank Address:
	  	 	  		  		  	
	 Account Number:
	  	 	  		  		  	
					
	 ABA Number:
	  	 	  		  		  	

 Dated:
                                        

 BORROWER: 
 ZALICUS INC. 

By                     
                                         
                               

Name:                     
                                         
                         
 Title:                                
                                         
                
 ZALICUS PHARMACEUTICALS LTD.

By                     
                                         
                               

Name:                     
                                         
                         
 Title:                                
                                         
                
 AS COLLATERAL AGENT AND AS A
LENDER: 
 OXFORD FINANCE CORPORATION 
 By                                
                                         
                    

Name:                     
                                         
                         
 Title:                                
                                         
                

 EXHIBIT C - COMPLIANCE CERTIFICATE 

 

													
	 	  	 TO:
	  	 Oxford Finance
 Corporation, as Collateral
 Agent
	  	 	  	 	  	 	  	 
						
		  	 FROM:
	  	 Zalicus Inc./Zalicus Pharmaceuticals Ltd.
	  		  		  	
		
		  	 The undersigned authorized officer of Zalicus Inc. and Zalicus Pharmaceuticals Ltd. (“Borrower”) hereby certifies that in accordance
with the terms and conditions of the Loan and Security Agreement dated as of December __, 2010, among Borrower, Guarantor, Collateral Agent, and the Lenders (the “Agreement”),

		
		  	 (i) Borrower and Guarantor are in compliance for the period ending _______________ with all required covenants except as noted
below;

		
		  	 (ii) There are no Events of Default, except as noted below;

		
		  	 (iii) Except as noted below, all representations and warranties of Borrower and Guarantor stated in the Loan Documents are true and correct
in all material respects on this date except as noted below; provided, however, that such materiality qualifier shall not be applicable to any representations and warranties that already are qualified or modified by materiality in the text thereof;
and provided, further that those representations and warranties expressly referring to a specific date shall be true, accurate and complete in all material respects as of such date.

		
		  	 (iv) Borrower, and each of its Subsidiaries, has timely filed all required tax returns and reports, and Borrower has timely paid all foreign,
federal, state, and local taxes, assessments, deposits and contributions owed by Borrower except as otherwise permitted pursuant to the terms of Section 5.8 of the Agreement;

		
		  	 (v) No Liens have been levied or claims made against Borrower or any of its Subsidiaries relating to unpaid employee payroll or benefits of which
Borrower has not previously provided written notification to Collateral Agent

		  	 Attached are the required documents, if any, supporting our certification(s). The Officer on behalf of Borrower further certifies that the
attached financial statements are prepared in accordance with Generally Accepted Accounting Principles (GAAP) and are consistently applied from one period to the next except as explained in an accompanying letter or footnotes and except, in the case
of unaudited financial statements, for the absence of footnotes and subject to year-end audit adjustments as to the interim financial statements. Capitalized terms used but not otherwise defined herein shall have the meanings given them in the
Agreement.

		
		  	 Please indicate compliance status since the last Compliance Certificate by circling Yes, No, or N/A under “Complies”
column.

					
	  	  	 Reporting Covenant

 
	  	 Requirement

 
	  	 	  	 Complies

 

	 1)
	  	 Financial statements
	  	 Quarterly within 45 days
	  		  	Yes	  	No	  	N/A
							
	 2)
	  	 Annual (CPA Audited) statements
	  	 Within 120 days after Fiscal Year End
	  		  	Yes	  	No	  	N/A
							
	 3)
	  	 Annual Financial Budget
	  	 Annually (w/n 60days of FYE), and when revised
	  		  	Yes	  	No	  	N/A

  

													
							
	 4)
	  	 A/R & A/P agings
	  	 If applicable
	  		  	Yes	  	No	  	N/A
							
	 5)
	  	 8-K, 10-K and 10-Q Filings
	  	 If applicable
	  		  	Yes	  	No	  	N/A
							
	 6)
	  	 IP Report
	  	 when required
	  		  	Yes	  	No	  	N/A
							
	 7)
	  	 Total amount of Borrower’s
 cash and cash equivalents
 at the last day of the

measurement period
	  		  	$________	  		  		  	
	 8)
	  		  	 Month
	  	QTD	  	YTD	  		  	
							
	 9)
	  		  		  	 $___________
	  		  		  	
			
		  	 Deposit and Securities
 Accounts
	  	         (Please list all accounts; attach separate sheet if additional space
needed)

					
	  	  	 Bank
	  	 Account Number
	  	 New Account?
	  	 Acct Control

Agmt in place?

	 1)
	  		  		  	Yes	  	No	  	Yes	  	No
							
	 2)
	  		  		  	Yes	  	No	  	Yes	  	No
							
	 3)
	  		  		  	Yes	  	No	  	Yes	  	No
							
	 4)
	  		  		  	Yes	  	No	  	Yes	  	No
							
	 5)
	  		  		  	Yes	  	No	  	Yes	  	No
							
	 6)
	  		  		  	Yes	  	No	  	Yes	  	No
							
	 7)
	  		  		  		  		  		  	
							
	 8)
	  		  		  		  		  		  	
							
	 9)
	  		  		  		  		  		  	
							
	 10)
	  		  		  		  		  		  	
							
		  	 Other Matters
	  		  		  		  		  	
						
		  	 Have there been any changes in any Key Person since the

last Compliance Certificate?
	  		  	 Yes
	  	 No
	  	
		  	 Have there been any transfers/sales/disposals/retirement of Collateral or IP

prohibited by the Agreement?
	  		  	 Yes
	  	 No
	  	
						
		  	 Have there been any new or pending claims or causes of action against

Borrower that involve more than $200,000?
	  		  	 Yes
	  	 No
	  	

  

															
		  	 Exceptions
	  		  	
			
		  	 Please explain any
	  	 
		  	 exceptions with respect to
 the certification above: (If
	  	 
		  	 no exceptions exist, state
 “No exceptions.” Attach
	  	 
		  	 separate sheet if additional
	  		  		  		  		  		  	
		  	 space needed.)
	  		  		  		  		  		  	
		  		  	 
								
		  		  		  		  		  		  		  	
		  		  	 	  		  	
LENDERS USE
 ONLY

		  	 ZALICUS INC.
	  	 DATE
	  		  		  		  		  	 
					 			 
		  	
By:                             
                       
	  		  		  	 Received by:
	  	_______	  	Verified by:	  	_______
					 			 
		  	
Name:                            
                   
	  		  		  		  		  		  	 
					 			 
		  	
Title:                            
                      
	  		  		  	 Date:
	  		  	Date:	  	 
		  		  		  		  		  	_______	  		  	_______
					 		 
		  		  		  		  	 Compliance Status
	  	Yes	  	No

 EXHIBIT D 

SECURED PROMISSORY NOTE 
  

			
	
$                     
           
	  	Dated:
                            , 2010

FOR VALUE RECEIVED, the undersigned, ZALICUS INC., a Delaware corporation with offices located at 245 First
Street, Third Floor, Cambridge, Massachusetts 02142 (“Zalicus”) and ZALICUS PHARMACEUTICALS LTD., a corporation organized under the laws of British Columbia, Canada (“Zalicus-Canada”) (Zalicus and
Zalicus-Canada are referred to herein individually and collectively, jointly and severally, solidarily, as “Borrower”)HEREBY PROMISES TO PAY to the order of OXFORD FINANCE CORPORATION (“Lender”) the principal
amount of [                    ] MILLION DOLLARS
[($                    )] or such lesser amount as shall equal the outstanding principal balance of the Term Loan made to Borrower by Lender,
plus interest on the aggregate unpaid principal amount of Term Loan, at the rates and in accordance with the terms of the Loan and Security Agreement dated as of December __, 2010, by and among Borrower, Oxford Finance Corporation, as Collateral
Agent and as a Lender, and the Lenders from time to time party thereto (as amended, restated, supplemented or otherwise modified from time to time, the “Loan Agreement”). If not sooner paid, the entire principal amount and all accrued and
unpaid interest hereunder shall be due and payable on the Maturity Date as set forth in the Loan Agreement. Any capitalized term not otherwise defined herein shall have the meaning attributed to such term in the Loan Agreement. 

Borrower agrees to pay any initial partial monthly interest payment from the date the Term Loan is made to Borrower under this Secured
Promissory Note (this “Note”) to the first Payment Date (“Interim Interest”) on the first Payment Date. 

Principal, interest and all other amounts due with respect to the Term Loan, are payable in lawful money of the United States of America
to Lender as set forth in the Loan Agreement and this Note. The principal amount of this Note and the interest rate applicable thereto, and all payments made with respect thereto, shall be recorded by Lender and, prior to any transfer hereof,
endorsed on the grid attached hereto which is part of this Note. 
 The Loan Agreement, among other things, (a) provides
for the making of secured Term Loans by Lender to Borrower, and (b) contains provisions for acceleration of the maturity hereof upon the happening of certain stated events. 

This Note may not be prepaid except as set forth in Section 2.2 (c) and Section 2.2(d) of the Loan Agreement. 

This Note and the obligation of Borrower to repay the unpaid principal amount of the Term Loan, interest on the Term Loan and all other
amounts due Lender under the Loan Agreement is secured under the Loan Agreement. 
 Presentment for payment, demand, notice of
protest and all other demands and notices of any kind in connection with the execution, delivery, performance and enforcement of this Note are hereby waived. 
 Borrower shall pay all reasonable documented fees and expenses, including, without limitation, reasonable documented attorneys’ fees and costs, incurred by Lender in the enforcement or attempt to
enforce any of Borrower’s obligations hereunder not performed when due. 
 This Note shall be governed by, and construed
and interpreted in accordance with, the internal laws of the State of New York. 
 Note Register; Ownership of Note. The
ownership of an interest in this Note shall be registered on a record of ownership maintained by Lender or its agent. Notwithstanding anything else in this Note to the contrary, the right to the principal of, and stated interest on, this Note may be
transferred only if the transfer is registered on such record of ownership and the transferee is identified as the owner of an interest in the obligation. Borrower shall be entitled to treat the registered holder of this Note (as recorded on such
record of ownership) as the owner in fact thereof for all purposes and shall not be bound to recognize any equitable or other claim to or interest in this Note on the part of any other person or entity. 

 IN WITNESS WHEREOF, Borrower has caused this Note to be duly executed by one
of its officers thereunto duly authorized on the date hereof. 
  

			
	BORROWER:
	
	 ZALICUS INC.

		
	 By
	 	 

			
	 Name:
	 	 
	 Title:
	 	 

			
	
	 ZALICUS PHARMACEUTICALS LTD.

		
	 By
	 	 

			
	 Name:
	 	 
	 Title:Transition Agreement

 Exhibit 10.1 

 

 

 December 20, 2010 
 Mr. Dirk M. Van Doren 
 Address on File 

 

	Re:	Transition Agreement 

 Dear Dirk: 

This letter amends the Employment Agreement, which was effective January 1, 2008 (the “Employment Agreement”) between you and SandRidge
Energy, Inc. (“SandRidge” or the “Company”), as follows: 
  

	1.	SandRidge hereby acknowledges that your anticipated separation from employment is a result of mutual discussions between you and SandRidge but that for purposes of this
letter agreement, shall be deemed a Termination without Cause pursuant to Section 6.1.1 of the Employment Agreement. Certain other aspects of your anticipated separation not addressed herein shall continue to be governed by Section 6.6 of
the Employment Agreement. 

  

	2.	You have agreed to continue your employment from the date of this letter through a date to be mutually agreed upon (the “Separation Date”), but expected to be
not later than December 31, 2010. 

  

	3.	Your current annualized base salary, paid in bi-weekly installments, will remain in effect through the Separation Date. Your job duties will be the same as those
previously identified under Section 2 of the Employment Agreement and as mutually agreed upon between you and Tom L. Ward. 

  

	4.	In accordance with Section 6.1.1 of the Employment Agreement, and subject to paragraphs 9 and 10 below, you will receive as termination compensation a lump sum
payment equal to 12 months current base salary as in effect on the Separation Date. Pursuant to Section 6.1.1 of the Employment Agreement and because you are a “specified employee” as defined in regulations under Section 409A of
the Internal Revenue Code of 1986, as amended (the “Code”), such payment will be paid on the first payroll payment date which is more than six months following the Separation Date. You agree that you are not eligible for any payment under
Section 6 of the Employment Agreement other than the payment under Section 6.1.1 described in this paragraph. 

 

 

 123 Robert S. Kerr Avenue, Oklahoma City, OK 73102 • Phone 405.429.5500, Fax 405.429.5977 •
www.sandridgeenergy.com 

 Mr. Dirk M. Van Doren 
 December 20, 2010 
  Page
 2
 of 3 
  

  

	5.	In exchange for your continued employment through the Separation Date, and subject to paragraphs 9 and 10, below, the Compensation Committee of the Board of Directors
(the “Compensation Committee”) has approved, and the Company agrees, that you will be eligible for a lump sum retention payment in the amount of $350,000, and this amount will be paid within 30 calendar days after the Separation Date. This
retention payment will not otherwise be “benefit bearing” and will not be considered as compensation for purposes of the Company’s 401(k) plan, the non-qualified deferred compensation plan or for accrual of PTO or other leave.

  

	6.	You will maintain your eligibility to participate in the Company’s health plan, 401(k) Plan and Nonqualified Retirement Plan through the Separation Date, subject
to the provisions as set forth in the applicable plan documents. Based on the recommendation of the Employee Benefits and Compensation Committee, in the event your employment ceases prior to December 31, 2010, the Compensation Committee has
approved, and the Company agrees that, you will maintain eligibility for matching contributions under the Nonqualified Retirement Plan to be made by the Company on your behalf on your base salary deferrals through the Separation Date. The valuation
of your account in the Nonqualified Retirement Plan, including such Company contributions, will occur 35 calendar days following your Separation Date. Any matching contributions made pursuant to this paragraph which would not otherwise be made under
the terms of the applicable plan document are subject to paragraphs 9 and 10, below. Because you are a “specified employee” as defined in Section 409A of the Code, you will be eligible for a distribution of your vested account in the
Nonqualified Retirement Plan the first day of the seventh month following the Separation Date. 

  

	7.	In exchange for your continued employment through the Separation Date, and subject to paragraphs 9 and 10, below, the Compensation Committee has approved, and the
Company agrees, that you will be eligible for accelerated vesting of your currently outstanding shares of restricted stock in the amount of 471,667 shares, with such vesting to be effective within 30 calendar days following the Separation Date.

  

	8.	You will be eligible for reimbursement of reasonable travel expenses incurred as a result of business necessity or at the request of SandRidge. Travel arrangements
should be made in accordance with SandRidge’s Travel and Business Expense Policy and scheduled through the designated company representative. 

  

	9.	Your right to the retention and termination compensation set forth in this letter is subject to your execution and nonrevocation of a revised version of the
Company’s standard Separation Agreement and General Release, a copy of which is attached to this letter. However, you should not execute the Separation Agreement and Release until after your Separation Date. 

 Mr. Dirk M. Van Doren 
 December 20, 2010 
  Page
 3
 of 3 
  

  

	10.	Your right to the retention and termination compensation set forth in this letter is conditioned upon your compliance with all of the provisions of the Employment
Agreement, including all post-employment obligations. 

  

	11.	The retention and termination compensation set forth in this letter may not be deferred under any of SandRidge’s employee benefit plans. 

 

	12.	The retention and termination compensation set forth in this letter is subject to mandatory deductions, which may include supplemental federal income tax withholding at
the applicable rate. 

  

	13.	The Employment Agreement continues to govern during the remainder of your employment with SandRidge and any post-employment obligations set forth in the Employment
Agreement shall remain in full force and effect following the Separation Date, including Sections 7, 8, 9, 10, 11, 12 and 13. In the event of any conflicts between this letter and the Employment Agreement, the provisions of this letter will control.

  

	14.	You acknowledge that your decision to enter into this agreement is voluntary and is made knowingly and that you have been advised by SandRidge to seek legal counsel to
review this letter agreement. 

 Please acknowledge your agreement to the provisions set forth in this letter agreement with your
signature below. 
  

			
	Sincerely,
		
	/s/ Tom L. Ward	 	
		
	Tom L. Ward	 	
	President and Chief Executive Officer	 	
		
	Agreed to:	 	
		
	/s/ Dirk M. Van Doren	 	December 20, 2010
	Dirk M. Van Doren	 	Date

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