Document:

EX-10.13

 Exhibit 10.13 

LEASE AGREEMENT 
 THIS
LEASE AGREEMENT (this “Lease”) is made this 1st day of April, 2015, between ARE-MA REGION NO. 38, LLC, a Delaware limited liability company (“Landlord”), and SERES HEALTH, INC., a Delaware
corporation (“Tenant”). 
 BASIC LEASE PROVISIONS 

 

			
	Address:		215 First Street, Cambridge, MA 02142
		
	Premises:		That portion of the Building (as defined below), containing approximately 7,484 rentable square feet, consisting of (i) Suite 440, and (ii) that certain storage area located on the first floor of the Building (“Storage
Area”), as shown on Exhibit A.
		
	Shared Science Facility:		That portion of the Building depicted as the “Shared Science Facility” on Exhibit B attached hereto, subject to adjustment and relocation by Landlord from time to time.
		
	Shared Conference Facility:		That portion of the Building depicted as the “Shared Conference Facility” on Exhibit C attached hereto, subject to adjustment and relocation by Landlord from time to time.
		
	Project:		The real property on which the Building is located, together with all improvements thereon and appurtenances thereto as described on Exhibit D.
		
	Building:		That building located on the Project and commonly known and numbered as 215 First Street, Cambridge, Massachusetts.
		
	Base Rent:		$35,549.00 per month, subject to adjustments as set forth in Section 3 below.
		
	Rent Adjustment Percentage:		3%
		
	Rentable Area of Premises:		Approximately 7,484 rentable square feet.
		
	Rentable Area of Project:		Approximately 366,723 rentable square feet.
		
	Tenant’s Share:		2.04%.
		
	Tenant’s Percentage Share (Science Facility):		8.62%
		
	Security Deposit:		$106,647.00
		
	Target Commencement Date:		April 1, 2015
		
	Base Term:		Beginning on the Commencement Date and ending 60 months from the first day of the first full month commencing on or after the Commencement Date.
		
	Permitted Use:		With respect to Suite 440, research and development laboratory, related office and other related uses consistent with the character of the Project and otherwise in compliance with the provisions of Section 6
hereof.

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			With respect to the Storage Area, the storage of flammable/solvent materials of Tenant in compliance with the provisions of Section 6 hereof and for no other use or purpose.

  

					
	Address for Rent Payment:		Landlord’s Notice Address:		Tenant’s Notice Address:
	 P.O. Box 975383
 Dallas, TX 75397-5383
		 385 East Colorado Boulevard, Suite 299

Pasadena, CA 91101
 Attention: Corporate Secretary

Facsimile: 626-578-0770
		 215 First Street, Suite 440
 Cambridge, MA
02142
 Attention: Lease Administrator

 1. Lease of Premises; Right to Use Common Areas; License to Shared Areas.  

(a) Lease of Premises; Common Areas. Upon and subject to all of the terms and conditions hereof, Landlord hereby leases the Premises to
Tenant and Tenant hereby leases the Premises from Landlord. The portions of the Project that are for the non-exclusive use of tenants of the Project (including but not limited to the restrooms, elevators, stairways, lobbies, corridors, walkways and
Building entrances) are collectively referred to herein as the “Common Areas.” Tenant shall have the non-exclusive right to use the Common Areas of the Project, excluding the Shared Science Facility and Shared Conference Facility to
which Tenant’s rights are as set forth in Section 1(b) below. Landlord reserves the right to modify, reconfigure and relocate the Common Areas, provided that such modifications, reconfigurations or relocations do not materially
adversely affect Tenant’s use of the Premises for the Permitted Use. Notwithstanding the foregoing, no interruption in Building Systems, services or Utilities, from any cause whatsoever, in connection with any work to effect any such
modification, reconfiguration or relocation shall result in eviction or constructive eviction of Tenant, termination of this Lease or the abatement of Rent. Landlord reserves the right to change the form of ownership of the Project or any part
thereof. From and after the Commencement Date through the expiration of the Term, Tenant shall have access to the Building and the Premises 24 hours a day, 7 days a week, except in the case of emergencies, as the result of Legal Requirements, the
performance by Landlord of any installation, maintenance or repairs, or any other temporary interruptions, and otherwise subject to the terms of this Lease. 

(b) Shared Science Facility; Shared Conference Facility. Concurrently with the execution and delivery of this Lease by Tenant, Tenant
shall execute and deliver to Landlord a license agreement in the form attached as Exhibit E attached hereto (the “License Agreement”). Tenant shall have the non-exclusive right to use the Shared Science Facility and Shared
Conference Facility pursuant to the terms and conditions of the License Agreement. Tenant shall have no right to use or access the Shared Science Facility or Shared Conference Facility, except as provided in the License Agreement. 

2. Delivery; Acceptance of Premises; Commencement Date. Landlord shall deliver (“Delivery” or
“Deliver”) the Premises to Tenant 1 business day after the mutual execution and delivery of this Lease by the parties and Tenant’s delivery to Landlord of an insurance certificate evidencing the insurance required to be
maintain by Tenant pursuant to Section 17 below. 
 The “Commencement Date” shall be the date that Landlord
Delivers the Premises to Tenant. Upon request of Landlord, Tenant shall execute and deliver a written acknowledgment of the Commencement Date and the expiration date of the Base Term when such are established in the form of the “Acknowledgement
of Commencement Date” attached to this Lease as Exhibit G; provided, however, the failure of Landlord or Tenant to execute and deliver such acknowledgment shall not affect Landlord’s or Tenant’s rights hereunder.
The “Term” of this Lease shall be the Base Term as defined above in the Basic Lease Provisions and the Extension Term which Tenant may elect pursuant to Section 35 hereof. 

Except as set forth in this Lease: (i) Tenant shall accept the Premises in their condition as of the Commencement Date, subject to all
applicable Legal Requirements (as defined in Section 7 hereof); 

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(ii) Landlord shall have no obligation for any defects in the Premises; and (iii) Tenant’s taking possession of the Premises shall be conclusive evidence that Tenant accepts the
Premises and that the Premises were in good condition at the time possession was taken. Any occupancy of the Premises by Tenant before the Commencement Date shall be subject to all of the terms and conditions of this Lease, including the obligation
to pay Base Rent and Operating Expenses. 
 As of the Commencement Date, Landlord shall make available to Tenant a “TI
Allowance” as follows: (a) a tenant improvement allowance of up to $10.00 per rentable square foot of the Premises, or $74,840 in the aggregate, which is included in Base Rent, and (b) an “Additional Tenant Improvement
Allowance” in the maximum amount of $10.00 per rentable square foot in the Premises, or $74,840 in the aggregate, which shall, to the extent used, result in adjustments to the Base Rent as set forth in Section 3(c) below. The TI
Allowance may be used solely for the design and construction of fixed and permanent improvements in the Premises desired by and performed by Tenant (the “Tenant Improvements”). Tenant acknowledges that upon the expiration of the
Term of the Lease, the Tenant Improvements shall become the property of Landlord and may not be removed by Tenant. Except for the TI Allowance, Tenant shall be solely responsible for all of the costs of the Tenant Improvements. The Tenant
Improvements shall be treated as Alterations and shall be undertaken pursuant to and in accordance with Section 10 of this Lease and shall be subject to Landlord’s prior written consent, which may be given or withheld in
Landlord’s sole discretion if any such Alteration affects the Building structure or Building Systems (as defined in Section 11) and shall not be otherwise unreasonably withheld, conditioned or delayed. Landlord and Tenant agree that
the plans attached to this Lease as Exhibit F (the “TI Plans”) have been approved by Landlord and Tenant and, to the extent that the Tenant Improvements performed by Tenant are substantially consistent with such plans, no
further consent or approval from Landlord shall be required with respect thereto. The contractor for the Tenant Improvements shall be selected by Tenant, subject to Landlord’s approval, which shall not be unreasonably withheld, conditioned or
delayed. Landlord hereby approves of The Richmond Group as the general contractor of the Tenant Improvements. Prior to the commencement of the Tenant Improvements, Tenant shall deliver to Landlord a copy of any contract with Tenant’s
contractors (including the architect), and certificates of insurance from any contractor performing any part of the Tenant Improvements evidencing industry standard commercial general liability, automotive liability, “builder’s risk”,
and workers’ compensation insurance. Tenant shall cause the general contractor to provide a certificate of insurance naming Landlord, Alexandria Real Estate Equities, Inc., and Landlord’s lender (if any) as additional insureds for the
general contractor’s liability coverages required above. During the course of design and construction of the Tenant Improvements, Landlord shall reimburse Tenant for the cost of the Tenant Improvements once a month against a draw request in
Landlord’s standard form, containing evidence of payment of the applicable costs and such certifications, lien waivers (including a conditional lien release for each progress payment and unconditional lien releases for the prior month’s
progress payments), inspection reports and other matters as Landlord customarily obtains, to the extent of Landlord’s approval thereof for payment, no later than 30 days following receipt of such draw request. Upon completion of the Tenant
Improvements (and prior to any final disbursement of the TI Allowance) Tenant shall deliver to Landlord the following items: (i) sworn statements setting forth the names of all contractors and subcontractors who did work on the Tenant
Improvements and final lien waivers from all such contractors and subcontractors; and (ii) “as built” plans or marked-up construction drawings for the Tenant Improvements. Landlord shall be entitled to receive the benefit of all
construction warranties and manufacturer’s equipment warranties relating to equipment installed in the Premises as part of the Tenant Improvements. Notwithstanding the foregoing, if the cost of the Tenant Improvements exceeds the TI Allowance,
Tenant shall be required to pay such excess prior to the distribution of the then-remaining unpaid TI Allowance. The TI Allowance shall only be available for use by Tenant for the construction of the Tenant Improvements in the Premises until the
date that is 12 months after the Commencement Date, and any portion of the TI Allowance which has not been requested for reimbursement by Tenant pursuant to the terms of this paragraph on or before the date that is 12 months after the Commencement
Date shall be forfeited and shall not be available for use by Tenant. 
 For the period of 90 consecutive days after the Commencement Date,
Landlord shall, at its sole cost and expense (which shall not constitute an Operating Expense), be responsible for any repairs that are required to be made to the Building or Building Systems, unless Tenant or any Tenant Party was responsible for
the cause of such repair, in which case Tenant shall pay the cost. 

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 Landlord and Tenant acknowledge and agree that, as of the Commencement Date, Landlord does
hereby unconditionally, absolutely, and irrevocably grant, bargain, sell, transfer, assign, convey, set over and deliver unto Tenant on an “as-is” basis, without any representations or warranties, express or implied of any kind whatsoever
by Landlord, all of Landlord’s right, title and interest in and to the furniture described on Exhibit K attached hereto. 

Except as otherwise specifically set forth in this Lease, Tenant agrees and acknowledges that neither Landlord nor any agent of Landlord has
made any representation or warranty with respect to the condition of all or any portion of the Premises or the Project, and/or the suitability of the Premises or the Project for the conduct of Tenant’s business, and Tenant waives any implied
warranty that the Premises or the Project are suitable for the Permitted Use. This Lease constitutes the complete agreement of Landlord and Tenant with respect to the subject matter hereof and supersedes any and all prior representations,
inducements, promises, agreements, understandings and negotiations which are not contained herein. 
 3. Base Rent. 

(a) Base Rent for the first full month of the Base Term and the Security Deposit shall be due and payable on delivery of an executed copy of
this Lease to Landlord. Tenant shall pay to Landlord in advance, equal monthly installments of Base Rent on or before the first day of each calendar month during the Term hereof, in lawful money of the United States of America, at the office or
address of Landlord for payment of Rent set forth above. Payments of Base Rent for any fractional calendar month shall be prorated. Except as expressly provided in Section 15 below, Tenant shall have no right at any time to abate,
reduce, or set-off any Rent due hereunder. Base Rent shall be increased on each anniversary of the Commencement Date (each an “Adjustment Date”) by multiplying the Base Rent payable immediately before such Adjustment Date by the
Rent Adjustment Percentage and adding the resulting amount to the Base Rent payable immediately before such Adjustment Date. Base Rent, as so adjusted, shall thereafter be due as otherwise provided herein. Base Rent adjustments for any fractional
calendar month shall be prorated. 
 (b) In addition to Base Rent, Tenant agrees to pay to Landlord as additional rent (“Additional
Rent”): (i) Tenant’s Share of Project Operating Expenses and Tenant’s Percentage Share (Science Facility) of Science Facility Operating Expenses (each as defined in Section 4), and (ii) any and all other
amounts Tenant assumes or agrees to pay under the provisions of this Lease, including, without limitation, any and all other sums that may become due by reason of any default of Tenant or failure to comply with the agreements, terms, covenants and
conditions of this Lease to be performed by Tenant, after any applicable notice and cure period. Tenant’s obligation to pay Base Rent and Additional Rent hereunder is collectively referred to herein as “Rent”. 

(c) Landlord shall, subject to the terms of Section 2, make available to Tenant the Additional Tenant Improvement Allowance.
Commencing on the first day of the calendar month following Landlord’s first disbursement of the Additional Tenant Improvement Allowance, and continuing thereafter on the first day of each month during the Base Term, Tenant shall pay the amount
necessary to fully amortize on a straight line basis the portion of the Additional Tenant Improvement Allowance actually funded by Landlord, if any, in equal monthly payments with interest at a rate of 8% per annum over the Base Term, which
interest shall begin to accrue on the date that Landlord first disburses such Additional Tenant Improvement Allowance or any portion(s) thereof and shall only accrue on the amounts actually disbursed,. Any of the Additional Tenant Improvement
Allowance and applicable interest remaining unpaid as of the expiration or earlier termination of the Lease shall be paid to Landlord in a lump sum at the expiration or earlier termination of this Lease. 

4. Operating Expense Payments. Landlord shall deliver to Tenant a written estimate of Project Operating Expenses and Science Facility
Operating Expenses for each calendar year during the 

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Term (together, the “Annual Estimate”), which may be revised by Landlord from time to time during such calendar year. Commencing on the Commencement Date and continuing
thereafter on the first day of each month during the Term, Tenant shall pay Landlord an amount equal to 1/12th of Tenant’s Share of Project Operating Expenses and 1/12th of Tenant’s Percentage Share (Science Facility) of Science Facility
Operating Expenses, each as shown on the Annual Estimate. Payments for any fractional calendar month shall be prorated. As used herein the term “Operating Expenses” shall mean collectively the Project Operating Expenses and the
Science Facility Operating Expenses (as such terms are hereinafter defined); and the term “Tenant’s Share of Operating Expenses” shall mean collectively Tenant’s Share of Project Operating Expenses and Tenant’s
Percentage Share (Science Facility) of Science Facility Operating Expenses. 
 The term “Project Operating Expenses” means
all costs and expenses of any kind or description whatsoever incurred or accrued each calendar year by Landlord with respect to the Project (including, without duplication, Taxes (as defined below in this Section 4), transportation
services (including costs associated with Landlord’s participation in the EZ-Ride shuttle or a successor shuttle service), capital repairs and replacements, and those capital improvements the purpose of which is to reduce Project Operating
Expenses and/or to comply with Legal Requirements first made effective after the date of this Lease, which capital repairs, replacements and capital improvements are in each case amortized over the lesser of 7 years and the useful life of such
capital items, and the costs of Landlord’s third party property manager or, if there is no third party property manager, administration rent in either case not to exceed 3.0% of Base Rent), excluding only: 

(a) the original construction costs of the Project and renovation prior to the date of the Lease and costs of correcting defects in such
original construction or renovation; 
 (b) capital expenditures for expansion of the Project or capital improvements that are not for the
purpose of reducing Project Operating Expenses and/or complying with Legal Requirements first made effective after the date of this Lease; 

(c) interest, principal payments of Mortgage (as defined in Section 23) debts of Landlord, financing costs and amortization of
funds borrowed by Landlord, whether secured or unsecured and all payments of base rent (but not taxes or operating expenses) under any ground lease or other underlying lease of all or any portion of the Project; 

(d) depreciation of the Project (except for those capital improvements, the cost of which are includable in Project Operating Expenses as
provided above in this Section 4); 
 (e) advertising, legal and space planning expenses and leasing commissions and other costs
and expenses incurred in procuring and leasing space to tenants for the Project, including any leasing office maintained in the Project, free rent and construction allowances for tenants; 

(f) legal and other expenses incurred in the negotiation or enforcement of leases; 

(g) completing, fixturing, improving, renovating, painting, redecorating or other work, which Landlord pays for or performs for other tenants
within their premises, and costs of correcting defects in such work; 
 (h) costs to be reimbursed by other tenants of the Project or Taxes
to be paid directly by Tenant or other tenants of the Project, whether or not actually paid; 
 (i) salaries, wages, benefits and other
compensation paid to officers and employees of Landlord who are not assigned in whole or in part to the operation, management, maintenance or repair of the Project; 

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 (j) general organizational, administrative and overhead costs relating to maintaining
Landlord’s existence, either as a corporation, partnership, or other entity, including general corporate, legal and accounting expenses; 

(k) costs (including attorneys’ fees and costs of settlement, judgments and payments in lieu thereof) incurred in connection with
disputes with tenants, other occupants, or prospective tenants, and costs and expenses, including legal fees, incurred in connection with negotiations or disputes with employees, consultants, management agents, leasing agents, purchasers or
mortgagees of the Building; 
 (l) costs incurred by Landlord due to the violation by Landlord, its employees, agents or contractors or any
tenant of the terms and conditions of any lease of space in the Project or any Legal Requirement (as defined in Section 6); 

(m) penalties, fines or interest incurred as a result of Landlord’s inability or failure to make payment of Taxes and/or to file any tax
or informational returns when due, or from Landlord’s failure to make any payment of Taxes required to be made by Landlord hereunder before delinquency; 

(n) overhead and profit increment paid to Landlord or to subsidiaries or affiliates of Landlord for goods and/or services in or to the Project
to the extent the same exceeds the costs of such goods and/or services rendered by unaffiliated third parties on a competitive basis; 
 (o)
costs of Landlord’s charitable or political contributions, or of fine art maintained at the Project; 
 (p) costs in connection with
services (including electricity), items or other benefits of a type which are not standard for the Project and which are not available to Tenant without specific charges therefor, but which are provided to another tenant or occupant of the Project,
whether or not such other tenant or occupant is specifically charged therefor by Landlord; 
 (q) costs incurred in the sale or refinancing
of the Project; 
 (r) net income taxes of Landlord or the owner of any interest in the Project, franchise, capital stock, gift, estate or
inheritance taxes or any federal, state or local documentary taxes imposed against the Project or any portion thereof or interest therein; 

(s) any expenses otherwise includable within Project Operating Expenses to the extent actually reimbursed by persons other than tenants of the
Project under leases for space in the Project; and 
 (t) any costs incurred to remove, test or remediate Hazardous Materials in or about
the Building or the Project (provided, however, that the foregoing is in no event intended to limit Tenant’s obligations under Section 24 and Section 26 of this Lease). 

Within 90 days after the end of each calendar year (or such longer period as may be reasonably required), Landlord shall furnish to Tenant a
statement (an “Annual Statement”) showing in reasonable detail: (a) the actual totals of Project Operating Expenses, Science Facility Operating Expenses, Tenant’s Share of Project Operating Expenses and Tenant’s
Percentage Share (Science Facility) of Science Facility Operating Expenses, in each case for the previous calendar year, and (b) the total of Tenant’s payments in respect of Project Operating Expenses and Science Facility Operating
Expenses for such year. If Tenant’s Share of actual Project Operating Expenses for such year exceeds Tenant’s payments of Project Operating Expenses for such year, or if Tenant’s Percentage Share (Science Facility) of actual Science
Facility Operating Expenses for such year exceeds Tenant’s payments of Science Facility Operating Expenses for such year, the excess shall be due and payable by Tenant as Rent within 30 days after delivery of such Annual Statement to Tenant. If
Tenant’s payments of Project Operating Expenses for such year exceed Tenant’s Share of actual Project Operating Expenses for such year, or if 

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Tenant’s payments of Science Facility Operating Expenses for such year exceed Tenant’s Percentage Share (Science Facility) of actual Science Facility Operating Expenses for such year,
Landlord shall pay the excess to Tenant within 30 days after delivery of such Annual Statement, except that after the expiration, or earlier termination of the Term or if Tenant is delinquent in its obligation to pay Rent, Landlord shall pay the
excess to Tenant after deducting all other amounts due Landlord. 
 The Annual Statement shall be final and binding upon Tenant unless
Tenant, within 90 days after Tenant’s receipt thereof, shall question or contest any item therein by giving written notice to Landlord, specifying each item questioned or contested and, if contested, the reason therefor. If, during such 90 day
period, Tenant reasonably and in good faith questions or contests the accuracy of Landlord’s statement of Tenant’s Share of Project Operating Expenses or Tenant’s Percentage Share (Science Facility) of Science Facility Operating
Expenses, Landlord will provide Tenant with access to Landlord’s books and records in connection with the operation of the Project and such information in connection with the operation of the Project reasonably necessary to be responsive to
Tenant’s questions (the “Expense Information”). If after Tenant’s review of such Expense Information, Landlord and Tenant cannot agree upon the amount of Tenant’s Share of Project Operating Expenses or Tenant’s
Percentage Share (Science Facility) of Science Facility Operating Expenses, then Tenant shall have the right to have an independent regionally recognized accounting firm selected by Tenant, working pursuant to a fee arrangement other than a
contingent fee (at Tenant’s sole cost and expense) and approved by Landlord (which approval shall not be unreasonably withheld or delayed), audit and/or review the Expense Information for the year in question (the “Independent
Review”). The results of any such Independent Review shall be binding on Landlord and Tenant. If the Independent Review shows that the payments actually made by Tenant with respect to Project Operating Expenses for the calendar year in
question exceeded Tenant’s Share of Project Operating Expenses for such calendar year, or that the payments actually made by Tenant with respect to Science Facility Operating Expenses for the calendar year in question exceeded Tenant’s
Percentage Share (Science Facility) of Science Facility Operating Expenses, Landlord shall at Landlord’s option either (i) credit the excess amount to the next succeeding installments of estimated Operating Expenses or (ii) pay the
excess to Tenant within 30 days after delivery of such statement, except that after the expiration or earlier termination of this Lease or if Tenant is delinquent in its obligation to pay Rent, Landlord shall pay the excess to Tenant after deducting
all other amounts due Landlord. If the Independent Review shows that Tenant’s payments with respect to Project Operating Expenses for such calendar year were less than Tenant’s Share of Project Operating Expenses for the calendar year, or
that Tenant’s payments with respect to Science Facility Operating Expenses for such calendar year were less than Tenant’s Percentage Share (Science Facility) of Science Facility Operating Expenses, Tenant shall pay the deficiency to
Landlord within 30 days after delivery of such statement. If the Independent Review shows that Tenant has overpaid with respect to Tenant’s Share of Project Operating Expenses and Science Facility Operating Expenses by more than 5% then
Landlord shall reimburse Tenant for all costs incurred by Tenant for the Independent Review. 
 Operating Expenses for the calendar years in
which Tenant’s obligation to share therein begins and ends shall include Operating Expenses for whole calendar months in such calendar years and any partial calendar months shall be prorated. Notwithstanding anything set forth herein to the
contrary, if the Project is not at least 95% occupied on average during any year of the Term, for such year those expenses included in Tenant’s Share of Project Operating Expenses that vary with the level of occupancy of the Building shall be
computed as though the Project had been 95% occupied on average during such year. 
 “Tenant’s Share” shall be the
percentage set forth in the Basic Lease Provisions as Tenant’s Share as reasonably adjusted by Landlord (upon no less than 30 days written notice to Tenant) for changes in the physical size of the Premises or the Project occurring thereafter.
Landlord may equitably increase or decrease Tenant’s Share for any item of expense or cost reimbursable by Tenant that relates to a repair, replacement, or service that benefits only the Premises or only a portion of the Project that includes
the Premises or that varies with occupancy or use. “Tenant’s Percentage Share (Science Facility)” means the percentage set forth in the Basic Lease Provisions, which Tenant’s Percentage Share (Science Facility) shall be
subject to further reasonable adjustment (upon no less than 30 days written notice to Tenant) for changes in the physical size of the Shared Science Facility or the Premises 

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occurring after the date of this Lease, and may be equitably increased or decreased for any item of expense or cost reimbursable that is specific to Tenant or that varies with occupancy or use or
to address variations in occupancy or use of the Shared Science Facility among Tenant and other tenants. In the event that Tenant’s Share is adjusted based on a remeasurement of the Premises as set forth above, Tenant’s Percentage Share
(Science Facility) shall be subject to a corresponding adjustment. “Science Facility Operating Expenses” means Landlord’s determination of all costs and expenses of any kind or description whatsoever incurred or accrued each
calendar year by Landlord with respect to the Shared Science Facility at the Project including, without duplication, water, sewer, electricity, gas and any other utilities serving such facilities, maintenance and repairs (including without
limitation maintenance contracts) for such facilities and equipment therein, reasonable reserves consistent with good business practice for future repairs and replacements, capital repairs and replacements, and those capital improvements the purpose
of which is to reduce Science Facility Operating Expenses and/or to comply with Legal Requirements first made effective after the date of this Lease, which capital repairs, replacements and capital improvements are in each case amortized over the
lesser of 7 years and the useful life of such capital items, the contractor fees and expenses and/or salaries, wages, benefits and other compensation paid to any personnel as may be assigned in whole or in part to such facilities, and any Taxes
assessed by a Governmental Authority (as defined below) with a valuation allocated to the Shared Science Facility in the Project, but excluding the same kinds of exclusions enumerating in clauses (a) through (u) above with respect to
Project Operating Expenses. For purposes of clarification, the parties agree that those specific expense items actually included in Science Facility Operating Expenses in a year shall not also be included as Project Operating Expenses in the same
year. 
 Landlord shall pay, as part of Operating Expenses, all taxes, levies, fees, assessments and governmental charges of any kind,
existing as of the Commencement Date or thereafter enacted (collectively referred to as “Taxes”), imposed by any federal, state, regional, municipal, local or other governmental authority or agency, including, without limitation,
quasi-public agencies (collectively, “Governmental Authority”) during the Term, including, without limitation, all Taxes: (i) imposed on or measured by or based, in whole or in part, on rent payable to (or gross receipts
received by) Landlord under this Lease and/or from the rental by Landlord of the Project or any portion thereof, or (ii) based on the square footage, assessed value or other measure or evaluation of any kind of the Premises, the Shared Science
Facility, or the Project, or (iii) assessed or imposed by or on the operation or maintenance of any portion of the Premises, the Shared Science Facility, or the Project, including parking, or (iv) assessed or imposed by, or at the
direction of, or resulting from Legal Requirements, or interpretations thereof, promulgated by, any Governmental Authority, or (v) imposed as a license or other fee, charge, tax or assessment on Landlord’s business or occupation of leasing
space in the Project. Landlord may contest by appropriate legal proceedings the amount, validity, or application of any Taxes or liens securing Taxes. Taxes shall not include any net income taxes imposed on Landlord except to the extent such net
income taxes are in substitution for any Taxes payable hereunder, nor franchise, conveyance or excise taxes. Project Operating Expenses hereunder shall also include the cost of tax monitoring services provided to Landlord with respect to the
Project. Tenant shall pay, prior to delinquency, any and all Taxes levied or assessed against any personal property or trade fixtures placed by Tenant in the Premises, whether levied or assessed against Landlord or Tenant. If any Taxes on
Tenant’s personal property or trade fixtures are levied against Landlord or Landlord’s property, or if the assessed valuation of the Project is increased by a value attributable to improvements in or alterations to the Premises, whether
owned by Landlord or Tenant and whether or not affixed to the real property so as to become a part thereof, higher than the base valuation on which Landlord from time-to-time allocates Taxes to all tenants in the Project, Landlord shall have the
right, but not the obligation, to pay such Taxes. Landlord’s determination of any excess assessed valuation shall be binding and conclusive, absent manifest error. The amount of any such payment by Landlord shall constitute Additional Rent due
from Tenant to Landlord immediately upon demand. If Landlord shall receive any abatement or refund of Taxes that does not derive from any vacancy in the Building or rent losses and such abatement or refund is for a time period for which Tenant has
made payments during the Term, then out of any balance remaining after deducting Landlord’s reasonable expenses incurred in obtaining such refund or abatement, Landlord shall, at Landlord’s option, either (i) credit the excess amount
determined by Landlord to be attributable to the Premises to the next succeeding installments of estimated Taxes or (ii) pay the excess amount determined by Landlord to be attributable to the Premises to Tenant within 30

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days after delivery of the Annual Statement, except that after the expiration or earlier termination of this Lease or if Tenant is delinquent in its obligation to pay Rent, Landlord shall pay
such excess amount determined by Landlord to be attributable to the Premises to Tenant after deducting all other amounts due Landlord. Nothing contained in this Lease shall obligate Landlord to seek a refund or abatement of Taxes. 

5. Security Deposit. Tenant shall deposit with Landlord, upon delivery of an executed copy of this Lease to Landlord, a security
deposit (the “Security Deposit”) for the performance of all of Tenant’s obligations hereunder in the amount set forth in the Basic Lease Provisions, which Security Deposit shall be in the form of an unconditional and
irrevocable letter of credit (the “Letter of Credit”): (i) in form and substance reasonably satisfactory to Landlord, (ii) naming Landlord as beneficiary, (iii) expressly allowing Landlord to draw upon it at
any time from time to time by delivering to the issuer notice that Landlord is entitled to draw thereunder, (iv) issued by an FDIC-insured financial institution reasonably satisfactory to Landlord, and (v) redeemable by presentation of a
sight draft (which may be presented by delivery by overnight courier) at the financial institution’s offices in the United States. With respect to any Letter of Credit given as a Security Deposit hereunder, if Tenant does not provide Landlord
with a substitute Letter of Credit complying with all of the requirements hereof at least 10 days before the stated expiration date of any then current Letter of Credit, Landlord shall have the right to draw the full amount of the current Letter of
Credit and hold the funds drawn in cash without obligation for interest thereon as the Security Deposit. The Security Deposit shall be held by Landlord as security for the performance of Tenant’s obligations under this Lease. The Security
Deposit does not constitute an advance rental deposit or a measure of Landlord’s damages in case of Tenant’s default. Upon each occurrence of a Default (as defined in Section 16), Landlord may use all or any part of the
Security Deposit to pay delinquent payments due under this Lease, and the cost of any damage, injury, expense or liability caused by such Default, without prejudice to any other remedy provided herein or provided by law. Tenant hereby waives the
provisions of any law, now or hereafter in force, which provide that Landlord may claim from a security deposit only those sums reasonably necessary to remedy defaults in the payment of Rent, to repair damage caused by Tenant or to clean the
Premises, it being agreed that Landlord may, in addition, claim those sums reasonably necessary to compensate Landlord for any other loss or damage, foreseeable or unforeseeable, caused by the act or omission of Tenant or any officer, employee,
agent or invitee of Tenant. Upon any such use of all or any portion of the Security Deposit, Tenant shall, within 5 days after demand from Landlord, restore the Security Deposit to its original amount. If Tenant shall fully perform every provision
of this Lease to be performed by Tenant, the Security Deposit, or any balance thereof (i.e., after deducting therefrom all amounts to which Landlord is entitled under the provisions of this Lease), shall be returned to Tenant (or, at Landlord’s
option, to the last assignee of Tenant’s interest hereunder) within 90 days after the expiration or earlier termination of this Lease. 

6. Use. The Premises shall be used solely for the Permitted Use set forth in the Basic Lease Provisions and in compliance with all
laws, orders, judgments, ordinances, regulations, codes, directives, permits, licenses, covenants and restrictions now or hereafter applicable to the Premises, and to the use and occupancy thereof, including, without limitation, the Americans With
Disabilities Act, 42 U.S.C. § 12101, et seq. (together with the regulations promulgated pursuant thereto, “ADA”) (collectively, “Legal Requirements” and each, a “Legal Requirement”). Tenant
shall, upon 5 days’ written notice from Landlord, discontinue any use of the Premises which is declared by any Governmental Authority having jurisdiction to be a violation of a Legal Requirement. Tenant will not use or permit the Premises to be
used for any purpose or in any manner that would void Tenant’s or Landlord’s insurance, increase the insurance risk, or cause the disallowance of any sprinkler or other credits. Landlord acknowledges that the use that Tenant has disclosed
to Landlord that Tenant will be making of the Premises as of the Commencement Date will not result in the voidance of or an increased insurance risk with respect to the insurance currently being maintained by Landlord. Tenant shall not permit any
part of the Premises to be used as a “place of public accommodation”, as defined in the ADA or any similar legal requirement. Tenant shall reimburse Landlord promptly upon demand (and delivery to Tenant of reasonable evidence thereof) for
any additional premium charged for any such insurance policy by reason of Tenant’s failure to comply with the provisions of this Section or otherwise caused by Tenant’s use and/or occupancy of the Premises. Tenant will not commit or permit
waste, overload the floor or structure of the Premises, subject 

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the Premises to use that would damage the Premises or obstruct or interfere with the rights of Landlord or other tenants or occupants of the Project, including conducting or giving notice of any
auction, liquidation, or going out of business sale on the Premises, or using or allowing the Premises to be used for any unlawful purpose. Tenant shall cause any equipment or machinery to be installed in the Premises so as to reasonably prevent
sounds or vibrations from the Premises from extending into Common Areas, or other space in the Project. Tenant shall not place any machinery or equipment weighing 750 pounds or more in or upon the Premises or transport or move such items through the
Common Areas of the Project or in the Project elevators without the prior written consent of Landlord, which consent shall not be unreasonably withheld, conditioned or delayed. Notwithstanding the foregoing, Landlord has reviewed the equipment plans
and structural assessment attached hereto as Exhibit L (“Equipment Plans”) and hereby consents to Tenant’s installation of equipment as shown therein. If and to the extent that the Equipment Plans change, Landlord may
require a new structural assessment and any such changes shall be subject to Landlord’s further consent as required under this Section. Tenant shall not, without the prior written consent of Landlord, use the Premises in any manner which will
require ventilation, air exchange, heating, gas, steam, electricity or water beyond the existing capacity of the Project as proportionately allocated to the Premises based upon Tenant’s Share as usually furnished for the Permitted Use. 

Landlord shall be responsible for the compliance of the Common Areas of the Project with the Legal Requirements as of the Commencement Date.
Following the Commencement Date, Landlord shall, as an Operating Expense (to the extent such Legal Requirement is generally applicable to similar buildings in the area in which the Project is located) and at Tenant’s expense (to the extent such
Legal Requirement is triggered by reason of Tenant’s, as compared to other tenants of the Project, specific use of the Premises or Tenant’s alterations) make any alterations or modifications to the Common Areas or the exterior of the
Building that are required by Legal Requirements. Tenant, at its sole expense, shall make any alterations or modifications to the interior of the Premises that are required by Legal Requirements (including, without limitation, compliance of the
Premises with the ADA) related to Tenant’s use or occupancy of the Premises. Notwithstanding any other provision herein to the contrary, Tenant shall be responsible for any and all demands, claims, liabilities, losses, costs, expenses, actions,
causes of action, damages or judgments, and all reasonable expenses incurred in investigating or resisting the same (including, without limitation, reasonable attorneys’ fees, charges and disbursements and costs of suit) (collectively,
“Claims”) arising out of or in connection with Legal Requirements related to Tenant’s use or occupancy of the Premises, and Tenant shall indemnify, defend, hold and save Landlord harmless from and against any and all such
Claims. 
 7. Holding Over. If Tenant remains in possession of the Premises after the expiration or earlier termination of the Term
without the express written consent of Landlord, (A) Tenant shall become a tenant at sufferance upon the terms of this Lease except that the monthly rental shall be equal to 150% of Rent in effect during the last 30 days of the Term, and
(B) Tenant shall be responsible for all damages suffered by Landlord resulting from or occasioned by Tenant’s holding over, including consequential damages, but otherwise excluding any special, punitive or exemplary damages. Acceptance by
Landlord of Rent after the expiration of the Term or earlier termination of this Lease shall not result in a renewal or reinstatement of this Lease. 

8. Parking. Subject to all matters of record, Force Majeure, a casualty or Taking (as defined in Section 15 below) and the
exercise by Landlord of its rights hereunder, Landlord shall make available to Tenant and Tenant shall lease from Landlord, at then-current market rates from time to time, 7 parking spaces in a parking lot or garage at an offsite location within a
10-minute walk of the Building, all of such parking spaces to be on a non-reserved basis. As of the Commencement Date, such parking spaces shall be located in the parking garage serving the 303
3rd Square Apartments. Parking spaces may, at Landlord’s discretion, become available for use during the Term in the parking garage serving 50-60 Binney. As of the Commencement Date, the
market parking rate for the parking spaces is $250 per parking space per month. Landlord shall not be responsible for enforcing Tenant’s parking rights against any third parties, including without limitation other tenants of the Project.
Landlord shall have the right, exercisable by notice to Tenant given at any time during the Term, to relocate all or a portion of the parking spaces made available to Tenant hereunder to another location within a 10-minute walk of the Building. 

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 9. Utilities, Services.  

(a) Landlord shall provide, subject to the terms of this Section 9, water, electricity, heat, air conditioning, light, power,
sewer, and other utilities (including gas and fire sprinklers to the extent the Project is plumbed for such services), and, for the office portion of the Premises only, refuse and trash collection and janitorial services (collectively,
“Utilities”). Landlord shall pay, as Operating Expenses or subject to Tenant’s reimbursement obligation, for all Utilities used on the Premises, all maintenance charges for Utilities, and any storm sewer charges or other
similar charges for Utilities imposed by any Governmental Authority or Utility provider, and any taxes, penalties, surcharges or similar charges thereon. Electricity serving the Premises will be separately submetered. Landlord may cause, at
Landlord’s expense, any Utilities to be separately metered or charged directly to Tenant by the provider. Tenant shall pay directly to the Utility provider, prior to delinquency, any separately metered Utilities and services which may be
furnished to Tenant or the Premises during the Term. Tenant shall pay, as part of Operating Expenses, its share of all charges for jointly metered Utilities based upon consumption, as reasonably determined by Landlord. No interruption or failure of
Utilities, from any cause whatsoever, shall result in eviction or constructive eviction of Tenant, termination of this Lease or the abatement of Rent. Tenant agrees to limit use of water and sewer with respect to Common Areas to normal restroom use.

 Notwithstanding anything to the contrary set forth herein, if (i) a stoppage of an Essential Service (as defined below) to the
Premises shall occur and such stoppage is due solely to the gross negligence or willful misconduct of Landlord and not due in any part to any act or omission on the part of Tenant or any Tenant Party or any matter beyond Landlord’s reasonable
control (any such stoppage of an Essential Service being hereinafter referred to as a “Service Interruption”), and (ii) such Service Interruption continues for more than 5 consecutive business days after Landlord shall have
received written notice thereof from Tenant, and (iii) as a result of such Service Interruption, the conduct of Tenant’s normal operations in the Premises are materially and adversely affected, then, there shall be an abatement of one
day’s Base Rent for each day during which such Service Interruption continues after such 5 business day period; provided, however, that if any part of the Premises is reasonably useable for Tenant’s normal business operations or if Tenant
conducts all or any part of its operations in any portion of the Premises notwithstanding such Service Interruption, then the amount of each daily abatement of Base Rent shall only be proportionate to the nature and extent of the interruption of
Tenant’s normal operations or ability to use the Premises. The rights granted to Tenant under this paragraph shall be Tenant’s sole and exclusive remedy resulting from a failure of Landlord to provide services, and Landlord shall not
otherwise be liable for any loss or damage suffered or sustained by Tenant resulting from any failure or cessation of services. For purposes hereof, the term “Essential Services” shall mean the following services: HVAC service,
water, sewer and electricity, but in each case only to the extent that Landlord has an obligation to provide same to Tenant under this Lease. 

(b) Tenant shall provide janitorial services and trash collection for the Premises, and Landlord shall provide as an Operating Expense a
dumpster and/or compactor at the loading dock for use by Tenant in common with others entitled thereto for the disposal of non-hazardous and non-controlled substances and material. 

(c) Tenant may use the freight elevator and loading dock in common with others entitled thereto at no additional charge. The regular hours of
operation of the freight elevator and loading dock are 24 hours per day, 7 days per week, subject to downtime for maintenance and repairs. 

(d) Landlord’s sole obligation for providing standby generators or any other standby power equipment, systems, furnishings or personal
property, whether or not affixed to the Building (collectively, the “Equipment”) shall be (i) to provide such Equipment as is determined by Landlord in its sole and absolute discretion, and (ii) to contract with a third
party (determined by Landlord to be qualified) to maintain the Equipment that is deemed by Landlord (in its reasonable professional discretion) to need periodic maintenance per the manufacturer’s standard maintenance guidelines. Notwithstanding
anything to the contrary contained herein, Landlord shall, at least once per month as part of the maintenance of the Building, run the emergency generator for a period reasonably determined by Landlord for the purpose of

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determining whether it operates when started. Landlord shall have no obligation to provide Tenant with operational Equipment, back-up Equipment or back-up
utilities or to supervise, oversee or confirm that the third party maintaining the Equipment is maintaining the Equipment as per the manufacturer’s standard guidelines or otherwise. During any period of replacement, repair or maintenance of the
Equipment when such Equipment is not operational, including any delays thereto due to the inability to obtain parts or replacements, Landlord shall have no obligation to provide Tenant with alternative or back-up Equipment or alternative sources of
utilities. Tenant expressly acknowledges and agrees that Landlord does not guaranty that the Equipment will be operational at all times, will function or perform adequately, or that emergency power will be available to the Premises when needed, and
Landlord shall not be liable for any damages resulting from the failure of such Equipment. Tenant hereby releases Landlord from and against any and all claims arising directly or indirectly out of or relating to the Equipment, or the existence, use
of failure thereof. The terms of this Section 9(d) shall survive the expiration or earlier termination of this Lease. 
 10.
Alterations; Tenant’s Property. Any alterations, additions, or improvements made to the Premises by or on behalf of Tenant (not including the Tenant Improvements performed by Tenant pursuant to Section 2), including
additional locks or bolts of any kind or nature upon any doors or windows in the Premises, but excluding installation, removal or realignment of furniture systems (other than removal of furniture systems owned or paid for by Landlord) not involving
any modifications to the structure or connections (other than by ordinary plugs or jacks) to Building Systems (as defined in Section 11(a) below) (“Alterations”) shall be subject to Landlord’s prior written consent,
which may be given or withheld in Landlord’s sole discretion if any such Alteration affects the structure or Building Systems, but which shall otherwise not be unreasonably withheld or delayed. Tenant may construct nonstructural Alterations in
the Premises without Landlord’s prior approval if the aggregate cost of all such work in any 12 month period does not exceed $50,000 (a “Notice-Only Alteration”), provided Tenant notifies Landlord in writing of such intended
Notice-Only Alteration, and such notice shall be accompanied by plans, specifications (to the extent that the nature of the Notice-Only Alterations is such that plans and specifications would typically be obtained), work contracts and such other
information concerning the nature and cost of the Notice-Only Alteration as may be reasonably requested by Landlord, which notice and accompanying materials shall be delivered to Landlord not less than 15 business days in advance of any proposed
construction. If Landlord approves any Alterations, Landlord may impose such conditions on Tenant in connection with the commencement, performance and completion of such Alterations as Landlord may deem appropriate in Landlord’s reasonable
discretion. Tenant agrees to take such steps as may be required, or as otherwise directed by Landlord, with respect to contractors and subcontractors performing any Alterations to ensure that no labor disruption, strikes, pickets, protests or other
similar labor actions occur on or about the Premises in connection with the performance of work on any Alterations. Any request for approval of Alterations shall be in writing, delivered not less than 15 business days in advance of any proposed
construction, and accompanied by plans, specifications, bid proposals, work contracts and such other information concerning the nature and cost of the Alterations as may be reasonably requested by Landlord, including the identities and mailing
addresses of all persons performing work or supplying materials. Landlord’s right to review plans and specifications and to monitor construction shall be solely for its own benefit, and Landlord shall have no duty to ensure that such plans and
specifications or construction comply with applicable Legal Requirements. Tenant shall cause, at its sole cost and expense, all Alterations to comply with insurance requirements and with Legal Requirements and shall implement at its sole cost and
expense any alteration or modification required by Legal Requirements as a result of any Alterations. Tenant shall pay to Landlord, as Additional Rent, within 10 days after demand Landlord’s reasonable out-of-pocket expenses for plan review,
coordination, scheduling and supervision in connection with any Alterations. Before Tenant begins any Alteration, Landlord may post on and about the Premises notices of non-responsibility pursuant to applicable law. Tenant shall reimburse Landlord
for, and indemnify and hold Landlord harmless from, any expense incurred by Landlord by reason of faulty work done by Tenant or its contractors, delays caused by such work, or inadequate cleanup. 

Tenant shall furnish security or make other arrangements satisfactory to Landlord to assure payment for the completion of all Alterations work
free and clear of liens, and shall provide (and cause each contractor or subcontractor to provide) certificates of insurance for workers’ compensation and other 

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coverage in amounts and from an insurance company reasonable satisfactory to Landlord protecting Landlord against liability for personal injury or property damage during construction. Upon
completion of any Alterations, Tenant shall deliver (or cause to be delivered) to Landlord: (i) sworn statements setting forth the names of all contractors and subcontractors who did the work and final lien waivers from all such contractors and
subcontractors; and (ii) “as built” plans for any such Alteration. 
 Other than (i) the items, if any, listed on
Exhibit H attached hereto, (ii) any items agreed by Landlord in writing to be included on Exhibit H in the future, and (iii) any trade fixtures, machinery, equipment and other personal property not installed by Landlord or
its contractor which may be removed without material damage to the Premises, which damage shall be repaired (including capping or terminating utility hook-ups behind walls) by Tenant during the Term (collectively, “Tenant’s
Property”), all property of any kind paid for by Landlord, Alterations, real property fixtures, built-in machinery and equipment, built-in casework and cabinets and other similar additions and improvements built into the Premises so as to
become an integral part of the Premises, such as fume hoods which penetrate the roof or plenum area, built-in cold rooms, built-in warm rooms, walk-in cold rooms, walk-in warm rooms, deionized water systems, glass washing equipment, autoclaves,
chillers, built-in plumbing, electrical and mechanical equipment and systems, and any power generator and transfer switch (collectively, “Installations”) shall be and shall remain the property of Landlord during the Term and
following the expiration or earlier termination of the Term, shall not be removed by Tenant at any time during the Term and shall remain upon and be surrendered with the Premises as a part thereof in accordance with Section 24 following
the expiration or earlier termination of this Lease; provided, however, that Landlord shall, at the time its approval of such Installation is requested, or at the time it receives notice of a Notice-Only Alteration, notify Tenant if it
has elected to cause Tenant to remove such Installation upon the expiration or earlier termination of this Lease. If Landlord so elects, Tenant shall remove such Installation upon the expiration or earlier termination of this Lease and restore any
damage caused by or occasioned as a result of such removal, including, when removing any of Tenant’s Property which was plumbed, wired or otherwise connected to any of the Building’s plumbing, electrical or other Building Systems, capping
off all such connections behind the walls of the Premises and repairing any holes. During any such restoration period, Tenant shall pay Rent to Landlord as provided herein as if said space were otherwise occupied by Tenant. Notwithstanding anything
to the contrary contained herein, any biosafety cabinets installed in the Premises and paid for by Tenant shall be the property of Tenant and may be removed by Tenant at the expiration of the Term, provided that Tenant restores any damage caused by
or occasioned as a result of Tenant’s removal of such biosafety cabinets. 
 Notwithstanding anything to the contrary contained in this
Lease, Tenant shall be required prior to the expiration or earlier termination of the Term, at Tenant’s sole cost and expense, to remove the Tenant Improvements and restore the Premises to its condition prior to the installation of the Tenant
Improvements (the “Premises Restoration”). If, as of the expiration or earlier termination of the Term, Tenant has not removed the Tenant Improvements and completed the Premises Restoration as required hereunder, Landlord may
undertake the removal of the Tenant Improvements and the Premises Restoration, and Tenant shall pay to Landlord, within 10 days after written demand by Landlord, the costs incurred by Landlord with respect to such removal of the Tenant Improvements
and Premises Restoration. 
 11. Repairs.  

(a) Landlord’s Repairs. Landlord, as an Operating Expense, shall maintain all of the structural, exterior, parking and other Common
Areas of the Project, including HVAC, plumbing, fire sprinklers, elevators and all other building systems serving the Premises and other portions of the Project (“Building Systems”), in good repair, reasonable wear and tear and
uninsured losses and damages caused by Tenant, or by any of Tenant’s agents, servants, employees, invitees and contractors (individually, a “Tenant Party” and collectively, “Tenant Parties”) excluded. Landlord
shall repair losses and damages caused by Tenant or any Tenant Party at Tenant’s sole cost and expense. Such maintenance and repairs by Landlord under this Section shall include Landlord’s making such replacements as Landlord may deem
necessary in its sole discretion. Landlord reserves the right to stop building system services when necessary. Landlord shall have no responsibility or liability for failure to 

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supply Building System services during any such period of interruption; provided, however, that Landlord shall make a commercially reasonable effort to give Tenant 24 hours advance
notice of any planned stoppage of Building System services for routine maintenance, repairs, alterations or improvements. Landlord shall not be liable for any failure to make any repairs or to perform any maintenance unless such failure shall
persist for an unreasonable time after Tenant’s written notice of the need for such repairs or maintenance. Tenant waives its rights under any state or local law to terminate this Lease or to make such repairs at Landlord’s expense and
agrees that the parties’ respective rights with respect to such matters shall be solely as set forth herein. Repairs required as the result of fire, earthquake, flood, vandalism, war, or similar cause of damage or destruction shall be
controlled by Section 15. 
 (b) Tenant’s Repairs. Subject to Section 11(a) and Section 15
hereof, Tenant, at its expense, shall repair, replace and maintain in good condition, damage covered by Section 15 excepted, all portions of the Premises, including, without limitation, entries, doors, ceilings, interior windows,
interior walls, and the interior side of demising walls. Such repair and replacement may include capital expenditures and repairs whose benefit may extend beyond the Term. Should Tenant fail to make any such repair or replacement or fail to maintain
the Premises, Landlord shall give Tenant notice of such failure. If Tenant fails to commence cure of such failure within 10 days of Landlord’s notice, and thereafter diligently prosecute such cure to completion, Landlord may perform such work
and shall be reimbursed by Tenant within 10 days after demand therefor; provided, however, that if such failure by Tenant creates or could create an emergency, Landlord may immediately commence cure of such failure and shall thereafter be entitled
to recover the costs of such cure from Tenant. Subject to Section 15, Tenant shall bear the full uninsured cost of any repair or replacement to any part of the Project that results from damage caused by Tenant or any Tenant Party and any
repair that benefits only the Premises. 
 12. Liens. Tenant shall discharge, by bond or otherwise, any mechanic’s lien filed
against the Premises or against the Project for work claimed to have been done for, or materials claimed to have been furnished to, Tenant 10 days after Tenant receives notice of the filing thereof, at Tenant’s sole cost and shall otherwise
keep the Premises and the Project free from any liens arising out of work performed, materials furnished or obligations incurred by Tenant. Should Tenant fail to discharge any lien described herein, Landlord shall have the right, but not the
obligation, to pay such claim or post a bond or otherwise provide security to eliminate the lien as a claim against title to the Project and the cost thereof shall be immediately due from Tenant as Additional Rent. If Tenant shall lease or finance
the acquisition of office equipment, furnishings, or other personal property of a removable nature utilized by Tenant in the operation of Tenant’s business, Tenant warrants that any Uniform Commercial Code Financing Statement filed as a matter
of public record by any lessor or creditor of Tenant will upon its face or by exhibit thereto indicate that such Financing Statement is applicable only to removable personal property of Tenant located within the Premises. In no event shall the
address of the Project be furnished on the statement without qualifying language as to applicability of the lien only to removable personal property, located in an identified suite held by Tenant. 

13. Indemnification. Tenant hereby indemnifies and agrees to defend, save and hold Landlord harmless from and against any and all
claims for injury or death to persons or damage to property (i) occurring within the Premises and arising directly or indirectly out of use or occupancy of the Premises, unless caused solely by the willful misconduct or negligence of Landlord,
(ii) occurring outside of the Premises (including without limitation in the Shared Science Facility or Shared Conference Facility) and arising directly or indirectly out of an act or failure of Tenant to take any action required of Tenant
whether under this Lease or otherwise, or (iii) arising directly or indirectly out of or a breach or default by Tenant in the performance of any of its obligations hereunder or under the License Agreement. Landlord shall not be liable to Tenant
for, and Tenant assumes all risk of damage to, personal property (including, without limitation, loss of records kept within the Premises or any part of the Project). Tenant further waives any and all claims for injury to Tenant’s business or
loss of income relating to any such damage or destruction of personal property (including, without limitation, any loss of records). Landlord shall not be liable for any damages arising from any act, omission or neglect of any tenant in the Project
or of any other third party. 

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 14. Insurance. Landlord shall, as an Operating Expense, maintain such insurance
covering the Project as Landlord shall reasonably determine. Tenant, at its sole cost and expense, shall maintain during the Term: all risk property insurance with business interruption and extra expense coverage, covering the full replacement cost
of all property and improvements installed or placed in the Premises by Tenant at Tenant’s expense; workers’ compensation insurance with no less than the minimum limits required by law; employer’s liability insurance with such limits
as required by law; and commercial general liability insurance, with a minimum limit of not less than $2,000,000 per occurrence for bodily injury and property damage with respect to the Premises, Shared Science Facility and Shared Conference
Facility. The commercial general liability insurance policy shall name Landlord, its officers, directors, employees, managers, members, agents, invitees and contractors (individually, a “Landlord Party” and collectively,
“Landlord Parties”) and Alexandria Real Estate Equities, Inc., as additional insureds; insure on an occurrence and not a claims-made basis; be issued by insurance companies which have a rating of not less than
policyholder rating of A and financial category rating of at least Class X in “Best’s Insurance Guide”; contain a hostile fire endorsement and a contractual liability endorsement; and provide primary coverage to Landlord (any policy
issued to Landlord providing duplicate or similar coverage shall be deemed excess over Tenant’s policies). Tenant shall (i) provide Landlord with 30 days advance written notice of cancellation of such commercial general liability policy,
and (ii) request Tenant’s insurer to endeavor to provide 30 days advance written notice to Landlord of cancellation of such commercial general liability policy (or 10 days in the event of a cancellation due to non-payment of premium).
Copies of such policies (if requested by Landlord), or certificates of insurance showing the limits of coverage required hereunder and showing Landlord as an additional insured, along with reasonable evidence of the payment of premiums for the
applicable period, shall be delivered to Landlord by Tenant upon commencement of the Term and upon each renewal of said insurance. Tenant’s policy may be a “blanket policy” with an aggregate per location endorsement which specifically
provides that the amount of insurance shall not be prejudiced by other losses covered by the policy. Tenant shall, at least 5 days prior to the expiration of such policies, furnish Landlord with renewal certificates. 

In each instance where insurance is to name Landlord as an additional insured, Tenant shall upon written request of Landlord also designate
and furnish certificates so evidencing Landlord as additional insured to: (i) any lender of Landlord holding a security interest in the Project or any portion thereof and any servicer in connection therewith, (ii) the landlord under any
lease wherein Landlord is tenant of the real property on which the Project is located, if the interest of Landlord is or shall become that of a tenant under a ground or other underlying lease rather than that of a fee owner, and/or (iii) any
management company retained by Landlord to manage the Project. 
 The property insurance obtained by Landlord and Tenant shall include a
waiver of subrogation by the insurers and all rights based upon an assignment from its insured, against Landlord or Tenant, and their respective officers, directors, employees, managers, members, agents, invitees and contractors (“Related
Parties”), in connection with any loss or damage thereby insured against. Neither party nor its respective Related Parties shall be liable to the other for loss or damage caused by any risk insured against under property insurance required
to be maintained hereunder, and each party waives any claims against the other party, and its respective Related Parties, for such loss or damage. The failure of a party to insure its property shall not void this waiver. Landlord and its respective
Related Parties shall not be liable for, and Tenant hereby waives all claims against such parties for, business interruption and losses occasioned thereby sustained by Tenant or any person claiming through Tenant resulting from any accident or
occurrence in or upon the Premises or the Project from any cause whatsoever. If the foregoing waivers shall contravene any law with respect to exculpatory agreements, the liability of Landlord or Tenant shall be deemed not released but shall be
secondary to the other’s insurer. 
 15. Condemnation and Casualty. If at any time during the Term the Premises, Common Areas or
Project is in whole or in part (i) materially damaged or destroyed by a fire or other casualty, or (ii) taken for any public or quasi-public use under governmental law, ordinance, or regulation, or by right of eminent domain, or by private
purchase in lieu thereof (a “Taking”), then this Lease shall, at the written election of Landlord delivered to Tenant within sixty (60) days following such casualty or taking, terminate as of the date of such damage,
destruction or Taking. If at any time during the Term the Premises or Common Areas are in whole or in part (x) materially damaged or destroyed by a fire or other casualty, or 

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(y) subject to a Taking, then this Lease shall, at the written election of Tenant delivered to Landlord within sixty (60) days following such casualty or taking, terminate as of the date of
such damage, destruction or Taking. Unless either Landlord or Tenant so elects to terminate this Lease, Landlord shall, subject to receipt of sufficient insurance proceeds (with any deductible to be treated as a current Operating Expense), promptly
restore the Premises and Common Areas (excluding the improvements installed by Tenant or by Landlord and paid for by Tenant), subject to delays arising from the collection of insurance proceeds, from Force Majeure events or as needed to obtain any
license, clearance or other authorization of any kind required to enter into and restore the Premises issued by any Governmental Authority having jurisdiction over the use, storage, handling, treatment, generation, release, disposal, removal or
remediation of Hazardous Materials (as defined in Section 26) in, on or about the Premises or Common Areas (collectively referred to herein as “Hazardous Materials Clearances”). 

If neither Tenant nor Landlord elect to terminate this Lease pursuant to the immediately preceding paragraph, Rent shall be abated from the
date all required Hazardous Material Clearances are obtained until the Premises or Common Areas are repaired and restored, in the proportion which the area of the Premises, if any, which is not usable by Tenant bears to the total area of the
Premises, unless Landlord provides Tenant with other space during the period of repair that is suitable for the temporary conduct of Tenant’s business. Such abatement shall be the sole remedy of Tenant, and except as provided in this
Section 15, Tenant waives any right to terminate the Lease by reason of damage or casualty loss, provided that, if Landlord shall fail to restore the Premises or Common Areas within 12 months after the receipt of any Hazardous Materials
Clearances determined by Landlord to be required (or if Landlord determines that no Hazardous Materials Clearances are required, within 12 months of the end of the 60-day period referred to in the first and second sentences of the immediately
preceding paragraph), Tenant shall have a further right to terminate this Lease by written notice to Landlord delivered within 60 days after the expiration of such 12-month period, provided further, that if Landlord completes such restoration within
30 days after receipt of Tenant’s termination notice, such termination notice shall be void and this Lease shall continue in full force and effect. 

The provisions of this Lease, including this Section 15, constitute an express agreement between Landlord and Tenant with respect
to any and all damage to, or destruction of, all or any part of the Premises, or any other portion of the Project, and any statute or regulation which is now or may hereafter be in effect shall have no application to this Lease or any damage or
destruction to all or any part of the Premises or any other portion of the Project, the parties hereto expressly agreeing that this Section 15 sets forth their entire understanding and agreement with respect to such matters. Upon any
fire or other casualty or Taking, Landlord shall be entitled to receive the entire proceeds of the insurance maintained by Landlord and the entire price or award from any such Taking without, in either case, any payment to Tenant, and Tenant hereby
assigns to Landlord Tenant’s interest, if any, in such proceeds or award, except that Tenant shall have the right, to the extent that same shall not diminish Landlord’s award, to make a separate claim against the condemning authority (but
not Landlord) for such compensation as may be separately awarded or recoverable by Tenant for moving expenses and damage to Tenant’s trade fixtures, if a separate award for such items is made to Tenant. 

16. Events of Default. Each of the following events shall be a default (“Default”) by Tenant under this Lease: 

(a) Payment Defaults. Tenant shall fail to pay any installment of Rent or any other payment hereunder when due; provided,
however, that Landlord will give Tenant notice and an opportunity to cure any failure to pay Rent within 5 business days of any such notice not more than once in any 12 month period. 

(b) Insurance. Any insurance required to be maintained by Tenant pursuant to this Lease shall be canceled or terminated or shall expire
or shall be reduced or materially changed, or Landlord shall receive a notice of nonrenewal of any such insurance and Tenant shall fail to obtain replacement insurance at least 20 days before the expiration of the current coverage. 

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 (c) Improper Transfer. Tenant shall assign, sublease or otherwise transfer or attempt
to transfer all or any portion of Tenant’s interest in this Lease or the Premises except as may be expressly permitted herein, or Tenant’s interest in this Lease shall be attached, executed upon, or otherwise judicially seized and such
action is not released within 90 days of the action. 
 (d) Liens. Tenant shall fail to discharge or otherwise obtain the release of
any lien upon the Premises in violation of this Lease within 10 days after any such lien is filed against the Premises. 
 (e) Insolvency
Events. Tenant or any guarantor or surety of Tenant’s obligations hereunder shall: (A) make a general assignment for the benefit of creditors; (B) commence any case, proceeding or other action seeking to have an order for relief
entered on its behalf as a debtor or to adjudicate it a bankrupt or insolvent, or seeking reorganization, arrangement, adjustment, liquidation, dissolution or composition of it or its debts or seeking appointment of a receiver, trustee, custodian or
other similar official for it or for all or of any substantial part of its property (collectively a “Proceeding for Relief”); (C) become the subject of any Proceeding for Relief which is not dismissed within 90 days of its
filing or entry; or (D) die or suffer a legal disability (if Tenant, guarantor, or surety is an individual) or be dissolved or otherwise fail to maintain its legal existence (if Tenant, guarantor or surety is a corporation, partnership or other
entity). 
 (f) Estoppel Certificate or Subordination Agreement. Tenant fails to execute any document required from Tenant under
Sections 19 or 23 within 5 days after a second notice requesting such document. 
 (g) Default under License. Tenant
shall be in default or breach of any of its obligations under the License beyond any cure period as may be expressly set forth in the License. 

(h) Other Defaults. Tenant shall fail to comply with any provision of this Lease other than those specifically referred to in this
Section 16, and, except as otherwise expressly provided herein, such failure shall continue for a period of 30 days after written notice thereof from Landlord to Tenant, provided that if the nature of such default is such that it cannot
be cured by the payment of money and reasonably requires more than 30 days to cure, then Tenant shall not be deemed to be in Default if Tenant commences such cure within 30 days of the aforesaid notice from Landlord and thereafter diligently
prosecutes such cure to completion within 90 days of the aforesaid notice from Landlord. Any notice given under this Section 16(h) shall: (i) specify the alleged default, (ii) demand that Tenant cure such default, (iii) be
in lieu of, and not in addition to, or shall be deemed to be, any notice required under any provision of applicable law, and (iv) not be deemed a forfeiture or a termination of this Lease unless Landlord elects otherwise in such notice. 

17. Landlord’s Remedies. 

(a) Payment By Landlord; Interest. Upon a Default by Tenant hereunder, Landlord may, without waiving or releasing any obligation of
Tenant hereunder, make such payment or perform such act that is the subject of the Default. All sums so paid or incurred by Landlord, together with interest thereon, from the date such sums were paid or incurred, at the annual rate equal to
12% per annum or the highest rate permitted by law (the “Default Rate”), whichever is less, shall be payable to Landlord on demand as Additional Rent. Nothing herein shall be construed to create or impose a duty on Landlord to
mitigate any damages resulting from Tenant’s Default hereunder. 
 (b) Late Payment Rent. Late payment by Tenant to Landlord of
Rent and other sums due will cause Landlord to incur costs not contemplated by this Lease, the exact amount of which will be extremely difficult and impracticable to ascertain. Such costs include, but are not limited to, processing and accounting
charges and late charges which may be imposed on Landlord under any Mortgage covering the Premises. Therefore, if any installment of Rent due from Tenant is not received by Landlord within 5 days after the date such payment is due, Tenant shall pay
to Landlord an additional sum of 6% of the overdue Rent as a late charge. Notwithstanding the foregoing, before assessing a late charge the first time in any calendar year, Landlord shall provide Tenant written notice of the delinquency and will

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waive the right if Tenant pays such delinquency within 5 business days thereafter. The parties agree that this late charge represents a fair and reasonable estimate of the costs Landlord will
incur by reason of late payment by Tenant. In addition to the late charge, Rent not paid when due shall bear interest at the Default Rate from the 5th day after the date due until paid. 

(c) Other Remedies. Upon and during the continuance of a Default, Landlord, at its option, without further notice or demand to Tenant,
shall have in addition to all other rights and remedies provided in this Lease, at law or in equity, the option to pursue any one or more of the following remedies, each and all of which shall be cumulative and nonexclusive, without any notice or
demand whatsoever. No cure in whole or in part of such Default by Tenant after Landlord has taken any action beyond giving Tenant notice of such Default to pursue any remedy provided for herein (including retaining counsel to file an action or
otherwise pursue any remedies) shall in any way affect Landlord’s right to pursue such remedy or any other remedy provided Landlord herein or under law or in equity, unless Landlord, in its sole discretion, elects to waive such Default. 

This Lease and the Term and estate hereby granted are subject to the limitation that whenever a Default shall have happened and be continuing, Landlord shall
have the right, at its election, then or thereafter while any such Default shall continue and notwithstanding the fact that Landlord may have some other remedy hereunder or at law or in equity, to give Tenant written notice of Landlord’s
intention to terminate this Lease on a date specified in such notice, which date shall be not less than 5 days after the giving of such notice, and upon the date so specified, this Lease and the estate hereby granted shall expire and terminate with
the same force and effect as if the date specified in such notice were the date hereinbefore fixed for the expiration of this Lease, and all rights of Tenant hereunder shall expire and terminate, and Tenant shall be liable as hereinafter in this
Section 17(c) provided. If any such notice is given, Landlord shall have, on such date so specified, the right of re-entry and possession of the Premises and the right to remove all persons and property therefrom and to store such
property in a warehouse or elsewhere at the risk and expense, and for the account, of Tenant. Should Landlord elect to re-enter as herein provided or should Landlord take possession pursuant to legal proceedings or pursuant to any notice provided
for by law, Landlord may from time to time re-let the Premises or any part thereof for such term or terms and at such rental or rentals and upon such terms and conditions as Landlord may deem advisable, with the right to make commercially reasonable
alterations in and repairs to the Premises. 
 (i) In the event of any termination of this Lease as in this
Section 17 provided or as required or permitted by law or in equity, Tenant shall forthwith quit and surrender the Premises to Landlord, and Landlord may, without further notice, enter upon, re-enter, possess and repossess the same by
summary proceedings, ejectment or otherwise, and again have, repossess and enjoy the same as if this Lease had not been made, and in any such event Tenant and no person claiming through or under Tenant by virtue of any law or an order of any court
shall be entitled to possession or to remain in possession of the Premises. Landlord, at its option, notwithstanding any other provision of this Lease, shall be entitled to recover from Tenant, as and for liquidated damages, the sum of; 

(A) all Base Rent, Additional Rent and other amounts payable by Tenant hereunder then due or accrued and unpaid: and 

(B) the amount equal to the aggregate of all unpaid Base Rent and Additional Rent which would have been payable if this Lease
had not been terminated prior to the end of the Term then in effect, discounted to its then present value in accordance with accepted financial practice using a rate of 5% per annum, for loss of the bargain; and 

(C) all other damages and expenses (including attorneys’ fees and expenses), if any, which Landlord shall have sustained
by reason of the breach of any provision of this Lease; less 

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 (D) the net proceeds of any re-letting actually received by Landlord and the
amount of damages which Tenant proves could have been avoided had Landlord taken reasonable steps to mitigate its damages. 

(ii) Nothing herein contained shall limit or prejudice the right of Landlord, in any bankruptcy or insolvency proceeding, to
prove for and obtain as liquidated damages by reason of such termination an amount equal to the maximum allowed by any bankruptcy or insolvency proceedings, or to prove for and obtain as liquidated damages by reason of such termination, an amount
equal to the maximum allowed by any statute or rule of law whether such amount shall be greater or less than the excess referred to above. 

(iii) Nothing in this Section 17 shall be deemed to affect the right of either party to indemnifications pursuant
to this Lease. 
 (iv) If Landlord terminates this Lease upon the occurrence of a Default, Tenant will quit and surrender the
Premises to Landlord or its agents, and Landlord may, without further notice, enter upon, re-enter and repossess the Premises by summary proceedings, ejectment or otherwise. The words “enter”, “re-enter”, and “re-entry”
are not restricted to their technical legal meanings. 
 (v) If either party shall be in default in the observance or
performance of any provision of this Lease, and an action shall be brought for the enforcement thereof in which it shall be determined that such party was in default, the party in default shall pay to the other all fees, costs and other expenses
which may become payable as a result thereof or in connection therewith, including attorneys’ fees and expenses. 
 (vi)
If Tenant shall default in the keeping, observance or performance of any covenant, agreement, term, provision or condition herein contained, Landlord, without thereby waiving such default, may perform the same for the account and at the expense of
Tenant (a) immediately or at any time thereafter and without notice in the case of emergency or in case such default will result in a violation of any legal or insurance requirements, or in the imposition of any lien against all or any portion
of the Premises, and (b) in any other case if such default continues after any applicable cure period provided in Section 16. All reasonable costs and expenses incurred by Landlord in connection with any such performance by it for
the account of Tenant and also all reasonable costs and expenses, including attorneys’ fees and disbursements incurred by Landlord in any action or proceeding (including any summary dispossess proceeding) brought by Landlord to enforce any
obligation of Tenant under this Lease and/or right of Landlord in or to the Premises, shall be paid by Tenant to Landlord within 10 days after demand. 

(vii) Independent of the exercise of any other remedy of Landlord hereunder or under applicable law, Landlord may conduct an
environmental test of the Premises as generally described in Section 26(c), at Tenant’s expense. 
 (viii)
In the event that Tenant is in breach or Default under this Lease, whether or not Landlord exercises its right to terminate or any other remedy, Tenant shall reimburse Landlord upon demand for any costs and expenses that Landlord may incur in
connection with any such breach or Default, as provided in this Section 17(c). Such costs shall include legal fees and costs incurred for the negotiation of a settlement, enforcement of rights or otherwise. Tenant shall also indemnify
Landlord against and hold Landlord harmless from all costs, expenses, demands and liability, including without limitation, legal fees and costs Landlord shall incur if Landlord shall become or be made a party to any claim or action instituted by
Tenant against any third party, or by or against any person holding any interest under or using the Premises by license of or agreement with Tenant. 

(d) Except as otherwise provided in this Section 17, no right or remedy herein conferred upon or reserved to Landlord is intended
to be exclusive of any other right or remedy, and every right and 

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remedy shall be cumulative and in addition to any other legal or equitable right or remedy given hereunder, or now or hereafter existing. No waiver of any provision of this Lease shall be deemed
to have been made unless expressly so made in writing. Landlord shall be entitled, to the extent permitted by law, to seek injunctive relief in case of the violation, or attempted or threatened violation, of any provision of this Lease, or to seek a
decree compelling observance or performance of any provision of this Lease, or to seek any other legal or equitable remedy. 
 18.
Assignment and Subletting.  
 (a) General Prohibition. Without Landlord’s prior written consent subject to and on
the conditions described in this Section 18, Tenant shall not, voluntarily or by operation of law, directly assign this Lease or sublease the Premises or any part thereof or mortgage, pledge, or hypothecate its leasehold interest or
grant any concession or license within the Premises. For the avoidance of doubt, any public offering of shares or other ownership interest in Tenant or any private equity financing by one or more investors who regularly invest in private
biotechnology companies for which Tenant has given Landlord prior written notice, shall not be deemed an assignment. Such prior written notice shall be treated by Landlord as confidential information. 

(b) Permitted Transfers. If Tenant desires to assign, sublease, hypothecate or otherwise transfer this Lease or sublet the Premises
other than pursuant to a Permitted Assignment (as defined below), then at least 15 business days, but not more than 90 business days, before the date Tenant desires the assignment or sublease to be effective (the “Assignment Date”),
Tenant shall give Landlord a notice (the “Assignment Notice”) containing such information about the proposed assignee or sublessee, including the proposed use of the Premises and any Hazardous Materials proposed to be used, stored
handled, treated, generated in or released or disposed of from the Premises, the Assignment Date, any relationship between Tenant and the proposed assignee or sublessee, and all material terms and conditions of the proposed assignment or sublease,
including a copy of any proposed assignment or sublease in its final form, and such other information as Landlord may deem reasonably necessary or appropriate to its consideration whether to grant its consent. Landlord may, by giving written notice
to Tenant within 15 business days after receipt of the Assignment Notice: (i) grant such consent, (ii) refuse such consent, in its reasonable discretion; or (iii) terminate this Lease with respect to the space described in the
Assignment Notice as of the Assignment Date (an “Assignment Termination”). Among other reasons, it shall be reasonable for Landlord to withhold its consent in any of these instances: (1) the proposed assignee or subtenant
is a governmental agency; (2) in Landlord’s reasonable judgment, the use of the Premises by the proposed assignee or subtenant would entail any alterations that would lessen the value of the leasehold improvements in the Premises, or would
require increased services by Landlord; (3) in Landlord’s reasonable judgment, the proposed assignee or subtenant is engaged in areas of scientific research or other business concerns that are controversial; (4) in Landlord’s
reasonable judgment, the proposed assignee or subtenant lacks the creditworthiness to support the financial obligations it will incur under the proposed assignment or sublease; (5) in Landlord’s reasonable judgment, the character,
reputation, or business of the proposed assignee or subtenant is inconsistent with the desired tenant-mix or the quality of other tenancies in the Project or is inconsistent with the type and quality of the nature of the Building; (6) Landlord
has received from any prior landlord to the proposed assignee or subtenant a negative report concerning such prior landlord’s experience with the proposed assignee or subtenant; (7) Landlord has experienced previous defaults by or is in
litigation with the proposed assignee or subtenant; (8) the use of the Premises by the proposed assignee or subtenant will violate any applicable Legal Requirement; (9) the proposed assignee or subtenant is an entity with whom Landlord is
then negotiating to lease space in the Project; or (10) the assignment or sublease is prohibited by Landlord’s lender. If Landlord delivers notice of its election to exercise an Assignment Termination, Tenant shall have the right to
withdraw such Assignment Notice by written notice to Landlord of such election within 5 business days after Landlord’s notice electing to exercise the Assignment Termination. If Tenant withdraws such Assignment Notice, this Lease shall continue
in full force and effect. If Tenant does not withdraw such Assignment Notice, this Lease, and the term and estate herein granted, shall terminate as of the Assignment Date with respect to the space described in such Assignment Notice. No failure of
Landlord to exercise any such option to terminate this Lease, or to deliver a timely notice in response to the Assignment Notice, shall be deemed to be Landlord’s consent to 

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the proposed assignment, sublease or other transfer. Tenant shall pay to Landlord a fee equal to One Thousand Five Hundred Dollars ($1,500) in connection with its consideration of any Assignment
Notice and/or its preparation or review of any consent documents. Notwithstanding the foregoing, Landlord’s consent to an assignment of this Lease or a subletting of any portion of the Premises to any entity controlling, controlled by or under
common control with Tenant (a “Permitted Assignment”) shall not be required, provided that Landlord shall have the right to approve the form of any such sublease or assignment, which approval shall not be unreasonably withheld,
conditioned or delayed. In addition, Tenant shall have the right to assign this Lease, upon not less than 30 days prior written notice to Landlord but without obtaining Landlord’s prior written consent, to a corporation or other entity
which is a successor-in-interest to Tenant, by way of merger, consolidation or corporate reorganization, or by the purchase of all or substantially all of the assets or the ownership interests of Tenant provided that (i) such merger or
consolidation, or such acquisition or assumption, as the case may be, is for a good business purpose and not principally for the purpose of transferring the Lease, and (ii) the net worth (as determined in accordance with generally accepted
accounting principles (“GAAP”)) of the assignee is not less than the greater of the net worth (as determined in accordance with GAAP) of Tenant as of (A) the Commencement Date, or (B) as of the date of Tenant’s most
current quarterly or annual financial statements, and (iii) such assignee shall agree in writing to assume all of the terms, covenants and conditions of this Lease arising after the effective date of the assignment (a “Corporate
Permitted Assignment”). Control Permitted Assignments and Corporate Permitted Assignments are hereinafter referred to as “Permitted Assignments.” 

(c) Additional Conditions. As a condition to any such assignment or subletting, whether or not Landlord’s consent is required,
Landlord may require: 
 (i) that any assignee or subtenant agree, in writing at the time of such assignment or subletting,
that if Landlord gives such party notice that Tenant is in Default under this Lease, such party shall thereafter make all payments otherwise due Tenant directly to Landlord, which payments will be received by Landlord without any liability except to
credit such payment against those due under the Lease, and any such third party shall agree to attorn to Landlord or its successors and assigns should this Lease be terminated for any reason; provided, however, in no event shall
Landlord or its successors or assigns be obligated to accept such attornment; and 
 (ii) A list of Hazardous Materials,
certified by the proposed assignee or sublessee to be true and correct, which the proposed assignee or sublessee intends to use, store, handle, treat, generate in or release or dispose of from the Premises, together with copies of all documents
relating to such use, storage, handling, treatment, generation, release or disposal of Hazardous Materials by the proposed assignee or subtenant in the Premises or on the Project, prior to the proposed assignment or subletting, including, without
limitation: permits; approvals; reports and correspondence; storage and management plans; plans relating to the installation of any storage tanks to be installed in or under the Project (provided, said installation of tanks shall only be permitted
after Landlord has given its written consent to do so, which consent may be withheld in Landlord’s sole and absolute discretion); and all closure plans or any other documents required by any and all federal, state and local Governmental
Authorities for any storage tanks installed in, on or under the Project for the closure of any such tanks. Neither Tenant nor any such proposed assignee or subtenant is required, however, to provide Landlord with any portion(s) of the such documents
containing information of a proprietary nature which, in and of themselves, do not contain a reference to any Hazardous Materials or hazardous activities. 

(d) No Release of Tenant, Sharing of Excess Rents. Notwithstanding any assignment or subletting, Tenant and any guarantor or surety of
Tenant’s obligations under this Lease shall at all times remain fully and primarily responsible and liable for the payment of Rent and for compliance with all of Tenant’s other obligations under this Lease. If the Rent due and payable by a
sublessee or assignee (or a combination of the rental payable under such sublease or assignment plus any bonus or other consideration therefor or incident thereto in any form) exceeds the sum of the rental payable under this Lease (excluding
however, any Rent payable under this Section) and actual and reasonable brokerage fees, legal costs and any design or construction fees directly related to and required pursuant to the terms 

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of any such sublease (“Excess Rent”), then Tenant shall be bound and obligated to pay Landlord as Additional Rent hereunder 50% of such Excess Rent within 10 days following
receipt thereof by Tenant. If Tenant shall sublet the Premises or any part thereof, Tenant hereby immediately and irrevocably assigns to Landlord, as security for Tenant’s obligations under this Lease, all rent from any such subletting, and
Landlord as assignee and as attorney-in-fact for Tenant, or a receiver for Tenant appointed on Landlord’s application, may collect such rent and apply it toward Tenant’s obligations under this Lease; except that, until the occurrence of a
Default, Tenant shall have the right to collect such rent. 
 (e) No Waiver. The consent by Landlord to an assignment or subletting
shall not relieve Tenant or any assignees of this Lease or any sublessees of the Premises from obtaining the consent of Landlord to any further assignment or subletting nor shall it release Tenant or any assignee or sublessee of Tenant from full and
primary liability under the Lease. The acceptance of Rent hereunder, or the acceptance of performance of any other term, covenant, or condition thereof, from any other person or entity shall not be deemed to be a waiver of any of the provisions of
this Lease or a consent to any subletting, assignment or other transfer of the Premises. 
 (f) Prior Conduct of Proposed Transferee.
Notwithstanding any other provision of this Section 18, if (i) the proposed assignee or sublessee of Tenant has been required by any prior landlord, lender or Governmental Authority to take remedial action in connection with
Hazardous Materials contaminating a property, where the contamination resulted from such party’s action or use of the property in question, (ii) the proposed assignee or sublessee is subject to an enforcement order issued by any
Governmental Authority in connection with the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials (including, without limitation, any order related to the failure to make a required reporting to any Governmental
Authority), or (iii) because of the existence of a pre-existing environmental condition in the vicinity of or underlying the Project, the risk that Landlord would be targeted as a responsible party in connection with the remediation of such
pre-existing environmental condition would be materially increased or exacerbated by the proposed use of Hazardous Materials by such proposed assignee or sublessee, Landlord shall have the absolute right to refuse to consent to any assignment or
subletting to any such party. 
 19. Estoppel Certificate. Tenant shall, within 10 business days of written notice from Landlord,
execute, acknowledge and deliver an estoppel certificate on any form reasonably requested by a proposed lender or purchaser. 
 20. Quiet
Enjoyment. So long as Tenant shall perform all of the covenants and agreements herein required to be performed by Tenant, Tenant shall, subject to the terms of this Lease, at all times during the Term, have peaceful and quiet enjoyment of the
Premises against any person claiming by, through or under Landlord. 
 21. Prorations. All prorations required or permitted to be
made hereunder shall be made on the basis of a 360-day year and 30-day months. 
 22. Rules and Regulations. Tenant shall, at all
times during the Term, comply with all reasonable rules and regulations at any time or from time to time established by Landlord covering use of the Premises and the Project. The current rules and regulations are attached hereto as Exhibit I.
If there is any conflict between said rules and regulations and other provisions of this Lease, the terms and provisions of this Lease shall control. Landlord shall not have any liability or obligation for the breach of any rules or regulations by
other tenants in the Project and shall not enforce such rules and regulations in a discriminatory manner. 
 23. Subordination. This
Lease and Tenant’s interest and rights hereunder are and shall be subject and subordinate at all times to the lien of any Mortgage now existing or hereafter created on or against the Project or the Premises, and all amendments, restatements,
renewals, modifications, consolidations, refinancing, assignments and extensions thereof, without the necessity of any further instrument or act on the part of Tenant. Tenant agrees, at the election of the Holder of any such Mortgage, to attorn to
any such Holder. Tenant agrees within 10 business days after demand to execute, 

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acknowledge and deliver such instruments confirming such subordination and/or attornment as shall be requested by any such Holder. Upon request of Tenant, Landlord shall use commercially
reasonable efforts to obtain from any future Holder of a Mortgage on the Project, if any, an agreement of non-disturbance, which agreement may also contain provisions for subordination, attornment and other terms and conditions of Holder. The term
“Mortgage” whenever used in this Lease shall be deemed to include deeds of trust, security assignments, ground leases or other superior leases and any other encumbrances, and any reference to the “Holder” of a
Mortgage shall be deemed to include the beneficiary under a deed of trust. 
 24. Surrender. Upon the expiration of the Term or
earlier termination of Tenant’s right of possession, Tenant shall surrender the Premises to Landlord in the same condition as received, subject to any Alterations or Installations permitted by Landlord or required to remain in the Premises in
accordance with Section 10, free of Hazardous Materials brought upon, kept, used, stored, handled, treated, generated in, or released or disposed of from, the Premises by any person other than Landlord or any Landlord Party
(collectively, “Tenant HazMat Operations”) and released of all Hazardous Materials Clearances, broom clean, ordinary wear and tear and casualty loss and condemnation covered by Section 15 excepted. At least 3 months
prior to the surrender of the Premises, Tenant shall deliver to Landlord a narrative description of the actions proposed (or required by any Governmental Authority) to be taken by Tenant in order to surrender the Premises at the expiration or
earlier termination of the Term, free from any residual impact from the Tenant HazMat Operations and otherwise released for unrestricted use and occupancy (the “Surrender Plan”). Such Surrender Plan shall be accompanied by a listing
of (i) all Hazardous Materials licenses and permits held by or on behalf of any Tenant Party with respect to the Premises, and (ii) all Hazardous Materials used, stored, handled, treated, generated, released or disposed of from the
Premises, and shall be subject to the review and approval of Landlord’s environmental consultant. In connection with the review and approval of the Surrender Plan, upon the request of Landlord, Tenant shall deliver to Landlord or its consultant
such additional non-proprietary information concerning Tenant HazMat Operations as Landlord shall request. On or before such surrender, Tenant shall deliver to Landlord evidence that the approved Surrender Plan shall have been satisfactorily
completed and Landlord shall have the right, subject to reimbursement at Tenant’s expense as set forth below, to cause Landlord’s environmental consultant to inspect the Premises and perform such additional procedures as may be deemed
reasonably necessary to confirm that the Premises are, as of the effective date of such surrender or early termination of the Lease, free from any residual impact from Tenant HazMat Operations. Tenant shall reimburse Landlord, as Additional Rent,
for the actual out-of pocket expense incurred by Landlord for Landlord’s environmental consultant to review and approve the Surrender Plan and to visit the Premises and verify satisfactory completion of the same, which cost shall not exceed
$2,500. Landlord shall have the unrestricted right to deliver such Surrender Plan and any report by Landlord’s environmental consultant with respect to the surrender of the Premises to third parties. 

If Tenant shall fail to prepare or submit a Surrender Plan approved by Landlord, or if Tenant shall fail to complete the approved Surrender
Plan, or if such Surrender Plan, whether or not approved by Landlord, shall fail to adequately address any residual effect of Tenant HazMat Operations in, on or about the Premises, Landlord shall have the right to take such actions as Landlord may
deem reasonable or appropriate to assure that the Premises and the Project are surrendered free from any residual impact from Tenant HazMat Operations, the cost of which actions shall be reimbursed by Tenant as Additional Rent, without regard to the
limitation set forth in the first paragraph of this Section 24. 
 Tenant shall immediately return to Landlord all keys and/or
access cards to parking, the Project, restrooms or all or any portion of the Premises furnished to or otherwise procured by Tenant. If any such access card or key is lost, Tenant shall pay to Landlord, at Landlord’s election, either the cost of
replacing such lost access card or key or the cost of reprogramming the access security system in which such access card was used or changing the lock or locks opened by such lost key. Any Tenant’s Property, Alterations and property not so
removed by Tenant as permitted or required herein shall be deemed abandoned and may be stored, removed, and disposed of by Landlord at Tenant’s expense, and Tenant waives all claims against Landlord for any damages resulting from
Landlord’s retention and/or disposition of such property. All obligations of Tenant hereunder not fully performed as of the termination of the 

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Term, including the obligations of Tenant under Section 26 hereof, shall survive the expiration or earlier termination of the Term, including, without limitation, indemnity
obligations, payment obligations with respect to Rent and obligations concerning the condition and repair of the Premises. 
 25. Waiver
of Jury Trial. TENANT AND LANDLORD WAIVE ANY RIGHT TO TRIAL BY JURY OR TO HAVE A JURY PARTICIPATE IN RESOLVING ANY DISPUTE, WHETHER SOUNDING IN CONTRACT, TORT, OR OTHERWISE, BETWEEN LANDLORD AND TENANT ARISING OUT OF THIS LEASE OR ANY OTHER
INSTRUMENT, DOCUMENT, OR AGREEMENT EXECUTED OR DELIVERED IN CONNECTION HEREWITH OR THE TRANSACTIONS RELATED HERETO. 
 26. Environmental
Requirements. 
 (a) Prohibition/Compliance/Indemnity. Tenant shall not cause or permit any Hazardous Materials (as hereinafter
defined) to be brought upon, kept, used, stored, handled, treated, generated in or about, or released or disposed of from, the Premises, Shared Science Facility or any other part of the Project in violation of applicable Environmental Requirements
(as hereinafter defined) by Tenant or any Tenant Party. If Tenant breaches the obligation stated in the preceding sentence, or if the presence of Hazardous Materials in the Premises during the Term or any holding over results in contamination of the
Premises, the Project or any adjacent property or if contamination of the Premises, the Project or any adjacent property by Hazardous Materials brought into, kept, used, stored, handled, treated, generated in or about, or released or disposed of
from, the Premises or Shared Science Facility by anyone other than Landlord or any Landlord Party otherwise occurs during the Term or any holding over, Tenant hereby indemnifies and shall defend and hold Landlord and each of the Landlord Parties
harmless from any and all actions (including, without limitation, remedial or enforcement actions of any kind, administrative or judicial proceedings, and orders or judgments arising out of or resulting therefrom), costs, claims, damages (including,
without limitation, punitive damages and damages based upon diminution in value of the Premises or the Project, or the loss of, or restriction on, use of the Premises or any portion of the Project), expenses (including, without limitation,
attorneys’, consultants’ and experts’ fees, court costs and amounts paid in settlement of any claims or actions), fines, forfeitures or other civil, administrative or criminal penalties, injunctive or other relief (whether or not
based upon personal injury, property damage, or contamination of, or adverse effects upon, the environment, water tables or natural resources), liabilities or losses (collectively, “Environmental Claims”) which arise during or after
the Term as a result of such breach by Tenant of its obligations stated in the preceding sentence or as a result of such contamination. This indemnification of Landlord by Tenant includes, without limitation, costs incurred in connection with any
investigation of site conditions or any cleanup, treatment, remedial, removal, or restoration work required by any federal, state or local Governmental Authority because of Hazardous Materials present in the air, soil or ground water above, on, or
under the Premises. Without limiting the foregoing, if the presence of any Hazardous Materials on the Premises, the Shared Science Facility, the Project or any adjacent property caused or permitted by Tenant or any Tenant Party results in any
contamination of the Premises, the Shared Science Facility, the Project or any adjacent property, Tenant shall promptly take all actions at its sole expense and in accordance with applicable Environmental Requirements as are necessary to return the
Premises, the Shared Science Facility, the Project or any adjacent property to the condition existing prior to the time of such contamination, provided that Landlord’s approval of such action shall first be obtained, which approval shall not
unreasonably be withheld so long as such actions would not potentially have any material adverse long-term or short-term effect on the Premises, the Shared Science Facility or the Project. Notwithstanding anything to the contrary contained in this
Section 26(a), Tenant shall not be responsible for the clean-up or remediation of, and the indemnification and hold harmless obligation set forth in this paragraph shall not apply to (i) contamination on the Project or in the
Premises that Tenant can demonstrate was present on the Project or in the Premises prior to the date of this Lease, (ii) the presence of any Hazardous Materials in the Premises which Tenant can demonstrate migrated from outside of the Premises
into the Premises; (iii) the presence of any Hazardous Materials in the Premises caused by Landlord or any Landlord’s employees, agents and contractors, or (iv) in the case of contamination in the Shared Science Facility or Shared
Conference Facility, the presence of which Tenant can demonstrate, was not caused by an act or omission of Tenant, except in any case to the extent Tenant and/or any of the Tenant Parties have exacerbated or contributed to such contamination, and
provided that it is understood that Tenant shall 

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have the burden of proof with respect to whether such contamination was present on the Project or in the Premises prior to the date of this Lease or whether such contamination in the Shared
Science Facility or Shared Conference Facility was not caused by an act or omission of Tenant. 
 (b) Business. As a material
inducement to Landlord to allow Tenant to use Hazardous Materials in connection with its business, Tenant agrees to deliver to Landlord, prior to the Commencement Date, a list identifying each type of Hazardous Materials to be brought upon, kept,
used, stored, handled, treated, generated on, or released or disposed of from, the Premises and setting forth any and all governmental approvals or permits required in connection with the presence, use, storage, handling, treatment, generation,
release or disposal of such Hazardous Materials on or from the Premises (“Hazardous Materials List”). Tenant shall deliver to Landlord true and correct copies of the following documents (the “Haz Mat Documents”)
relating to the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials prior to the Commencement Date (or if unavailable at that time, concurrent with the receipt from or submission to a Governmental Authority):
permits; approvals; reports and correspondence; storage and management plans; and notices of violations of any Legal Requirements. Tenant hereby represents and warrants to Landlord that (i) Tenant has not been required by any prior landlord or
governmental authority to take remedial action in connection with Hazardous Materials contaminating a property, where the contamination resulted from such party’s action or use of the property in question; and (ii) Tenant is not subject to
an enforcement order issued by any governmental authority in connection with the use, storage, handling, treatment, generation, release or disposal of Hazardous Materials. If Landlord determines that this representation and warranty was not true as
of the date of this lease, Landlord shall have the right to terminate this Lease in Landlord’s sole and absolute discretion. Tenant shall be permitted, however, to redact any portions(s) of the Haz Mat Documents containing information of a
proprietary nature which, in and of themselves, do not contain a reference to any Hazardous Materials or hazardous activities. 
 (c)
Landlord’s Tests. Landlord shall have access to, and a right to perform inspections and tests of, the Premises and the Shared Science Facility to determine Tenant’s compliance with Environmental Requirements, its obligations under
this Section 26, or the environmental condition of the Premises, the Shared Science Facility or the Project. In connection with such testing, upon the request of Landlord, Tenant shall deliver to Landlord or its consultant such
non-proprietary information concerning the use of Hazardous Materials in or about the Premises and Shared Science Facility by Tenant or any Tenant Party. Access to the Premises shall be granted to Landlord upon Landlord’s prior notice to Tenant
and at such times so as to minimize, so far as may be reasonable under the circumstances, any disturbance to Tenant’s operations. Such inspections and tests shall be conducted at Landlord’s expense, unless such inspections or tests reveal
that Tenant has not complied with any Environmental Requirement, in which case Tenant shall reimburse Landlord for the reasonable cost of such inspection and tests. Tenant shall, at its sole cost and expense, promptly and satisfactorily remediate
any environmental conditions for which Tenant is responsible pursuant to this Section 26 and that are identified by such testing in accordance with all Environmental Requirements. Landlord’s receipt of or satisfaction with any
environmental assessment in no way waives any rights that Landlord may have against Tenant. 
 (d) Tenant’s Obligations.
Tenant’s obligations under this Section 26 shall survive the expiration or earlier termination of the Lease. During any period of time after the expiration or earlier termination of this Lease required by Tenant or Landlord to
complete the removal from the Premises of any Hazardous Materials for which Tenant is responsible under this Lease (including, without limitation, the release and termination of any licenses or permits restricting the use of the Premises and the
completion of the approved Surrender Plan), Tenant shall continue to pay the full Rent in accordance with this Lease for any portion of the Premises not relet by Landlord in Landlord’s sole discretion, which Rent shall be prorated daily. 

(e) Definitions. As used herein, the term “Environmental Requirements” means all applicable present and future
statutes, regulations, ordinances, rules, codes, judgments, orders or other similar enactments of any Governmental Authority regulating or relating to health, safety, or environmental conditions on, under, or about the Premises or the Project, or
the environment, including 

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without limitation, the following: the Comprehensive Environmental Response, Compensation and Liability Act; the Resource Conservation and Recovery Act; and all state and local counterparts
thereto, and any regulations or policies promulgated or issued thereunder. As used herein, the term “Hazardous Materials” means and includes any substance, material, waste, pollutant, or contaminant listed or defined as hazardous or
toxic, or regulated by reason of its impact or potential impact on humans, animals and/or the environment under any Environmental Requirements, asbestos and petroleum, including crude oil or any fraction thereof, natural gas liquids, liquefied
natural gas, or synthetic gas usable for fuel (or mixtures of natural gas and such synthetic gas). As defined in Environmental Requirements, Tenant is and shall be deemed to be the “operator” of Tenant’s
“facility” and the “owner” of all Hazardous Materials brought on the Premises by Tenant or any Tenant Party, and the wastes, by-products, or residues generated, resulting, or produced therefrom. 

(f) Asbestos. 

(i) Notification of Asbestos. Landlord hereby notifies Tenant of the presence of asbestos-containing materials
(“ACMs”) and/or presumed asbestos-containing materials (“PACMs”) within or about the Premises in the locations identified in Exhibit J attached hereto. 

(ii) Tenant Acknowledgement. Tenant hereby acknowledges receipt of the notification in paragraph (i) of this
Section 26 and understand that the purpose of such notification is to make Tenant, and any agents, employees, and contractors of Tenant, aware of the presence of ACMs and/or PACMs within or about the Building in order to avoid or
minimize any damage to or disturbance of such ACMs and/or PACMs. 
         /s/
EDS         
 Tenant’s Initials 

(iii) Acknowledgement from Contractors/Employees. Tenant shall give Landlord at least 14 days’ prior written
notice before conducting, authorizing or permitting any of the activities listed below within or about the Premises, and before soliciting bids from any person to perform such services. Such notice shall identify or describe the proposed scope,
location, date and time of such activities and the name, address and telephone number of each person who may be conducting such activities. Thereafter, Tenant shall grant Landlord reasonable access to the Premises to determine whether any ACMs or
PACMs will be disturbed in connection with such activities. Tenant shall not solicit bids from any person for the performance of such activities without Landlord’s prior written approval (such approval not to be unreasonably withheld). Upon
Landlord’s request, Tenant shall deliver to Landlord a copy of a signed acknowledgement from any contractor, agent, or employee of Tenant acknowledging receipt of information describing the presence of ACMs and/or PACMs within or about the
Premises in the locations identified in Exhibit J prior to the commencement of such activities. Nothing in this Section 26 shall be deemed to expand Tenant’s rights under the Lease or otherwise to conduct, authorize or permit
any such activities. 
 (A) Removal of thermal system insulation (“TSI”) and surfacing ACMs and PACMs (i.e.,
sprayed-on or troweled-on material, e.g., textured ceiling paint or fireproofing material); 
 (B) Removal of ACMs or PACMs
that are not TSI or surfacing ACMs or PACMs; or 
 (C) Repair and maintenance of operations that are likely to disturb ACMs
or PACMs. 
 27. Tenant’s Remedies/Limitation of Liability. Landlord shall not be in default hereunder unless Landlord fails to
perform any of its obligations hereunder within 30 days after written notice from 

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Tenant specifying such failure (unless such performance will, due to the nature of the obligation, require a period of time in excess of 30 days, then after such period of time as is reasonably
necessary), provided, however, that if the nature of Landlord’s obligation arises from an emergency condition and Tenant provides notice to Landlord (which may be telephonic if followed by written notice on the same day describing the emergency
condition in reasonable detail, including without limitation the emergency nature of the condition and specifying in all capital letters and boldface type that the condition is an emergency and response is required by Landlord pursuant to the
Lease), then Landlord shall respond within a reasonable period after receipt of such notice of the emergency condition. Upon any default by Landlord, Tenant shall give notice by registered or certified mail to any Holder of a Mortgage covering the
Premises and to any landlord of any lease of property in or on which the Premises are located and Tenant shall offer such Holder and/or landlord a reasonable opportunity to cure the default, including time to obtain possession of the Project by
power of sale or a judicial action if such should prove necessary to effect a cure; provided Landlord shall have furnished to Tenant in writing the names and addresses of all such persons who are to receive such notices. All obligations of
Landlord hereunder shall be construed as covenants, not conditions; and, except as may be otherwise expressly provided in this Lease, Tenant may not terminate this Lease for breach of Landlord’s obligations hereunder. 

28. Inspection and Access. Subject to the next sentence, Landlord and its agents, representatives, and contractors may enter the
Premises at any reasonable time upon not less than 2 business days’ advance written notice (except in the case of emergencies in which case no such notice shall be required and such entry may be at any time), to inspect the Premises and to make
such repairs as may be required or permitted pursuant to this Lease, to perform such environmental tests as may be reasonably required to confirm Tenant’s compliance with the terms hereof and for any other business purpose. Landlord and
Landlord’s representatives may enter the Premises during business hours on not less than 48 hours advance written notice (except in the case of emergencies in which case no such notice shall be required and such entry may be at any time) for
the purpose of effecting any such repairs, inspecting the Premises, showing the Premises to prospective purchasers and, during the last year of the Term, to prospective tenants or for any other business purpose. Landlord shall use reasonable efforts
to minimize interference with Tenant’s operations in the Premises in connection with Landlord’s activities conducted pursuant to this paragraph. 

29. Security. Tenant acknowledges and agrees that security devices and services, if any, while intended to deter crime may not in given
instances prevent theft or other criminal acts and that Landlord is not providing any security services with respect to the Premises, Shared Science Facility, Shared Conference Facility or Common Areas. Tenant agrees that Landlord shall not be
liable to Tenant for, and Tenant waives any claim against Landlord with respect to, any loss by theft or any other damage suffered or incurred by Tenant in connection with any unauthorized entry into the Premises, Shared Science Facility, Shared
Conference Facility or Common Areas or any other breach of security with respect to the Premises, Shared Science Facility, Shared Conference Facility, Common Areas or other portion of the Project. Tenant shall be solely responsible for the personal
safety of Tenant’s officers, employees, agents, contractors, guests and invitees while any such person is in, on or about the Premises and/or the Project. Tenant shall at Tenant’s cost obtain insurance coverage to the extent Tenant desires
protection against such criminal acts. 
 30. Brokers. Landlord and Tenant each represents and warrants that it has not dealt with
any broker, agent or other person (collectively, “Broker”) in connection with this transaction and that no Broker brought about this transaction, other than Cushman & Wakefield. Landlord and Tenant each hereby agree to
indemnify and hold the other harmless from and against any claims by any Broker, other than the broker, if any named in this Section 30, claiming a commission or other form of compensation by virtue of having dealt with Tenant or
Landlord, as applicable, with regard to this leasing transaction. 
 31. Limitation on Landlord’s Liability. NOTWITHSTANDING
ANYTHING SET FORTH HEREIN OR IN ANY OTHER AGREEMENT BETWEEN LANDLORD AND TENANT TO THE CONTRARY: (A) LANDLORD SHALL NOT BE LIABLE TO TENANT OR ANY OTHER PERSON FOR (AND TENANT AND EACH SUCH OTHER PERSON ASSUME ALL RISK OF) LOSS, DAMAGE OR
INJURY, WHETHER ACTUAL OR CONSEQUENTIAL TO: TENANT’S PERSONAL PROPERTY OF 

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EVERY KIND AND DESCRIPTION, INCLUDING, WITHOUT LIMITATION TRADE FIXTURES, EQUIPMENT, INVENTORY, SCIENTIFIC RESEARCH, SCIENTIFIC EXPERIMENTS, LABORATORY ANIMALS, PRODUCT, SPECIMENS, SAMPLES,
AND/OR SCIENTIFIC, BUSINESS, ACCOUNTING AND OTHER RECORDS OF EVERY KIND AND DESCRIPTION KEPT AT THE PREMISES AND ANY AND ALL INCOME DERIVED OR DERIVABLE THEREFROM; (B) THERE SHALL BE NO PERSONAL RECOURSE TO LANDLORD FOR ANY ACT OR OCCURRENCE
IN, ON OR ABOUT THE PREMISES OR ARISING IN ANY WAY UNDER THIS LEASE OR ANY OTHER AGREEMENT BETWEEN LANDLORD AND TENANT WITH RESPECT TO THE SUBJECT MATTER HEREOF AND ANY LIABILITY OF LANDLORD HEREUNDER SHALL BE STRICTLY LIMITED SOLELY TO
LANDLORD’S INTEREST IN THE PROJECT OR ANY PROCEEDS FROM SALE OR CONDEMNATION THEREOF AND ANY INSURANCE PROCEEDS PAYABLE IN RESPECT OF LANDLORD’S INTEREST IN THE PROJECT OR IN CONNECTION WITH ANY SUCH LOSS; AND (C) IN NO EVENT SHALL
ANY PERSONAL LIABILITY BE ASSERTED AGAINST LANDLORD OR ITS OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS IN CONNECTION WITH THIS LEASE NOR SHALL ANY RECOURSE BE HAD TO ANY OTHER PROPERTY OR ASSETS OF LANDLORD OR ANY OF LANDLORD’S
OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS. UNDER NO CIRCUMSTANCES SHALL LANDLORD OR ANY OF LANDLORD’S OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS BE LIABLE FOR INJURY TO TENANT’S BUSINESS OR FOR ANY LOSS OF INCOME OR
PROFIT THEREFROM. 
 32. Severability. If any clause or provision of this Lease is illegal, invalid or unenforceable under present or
future laws, then and in that event, it is the intention of the parties hereto that the remainder of this Lease shall not be affected thereby. 

33. Signs; Exterior Appearance. Tenant shall not: (i) attach anything at any time to any outside wall of the Project,
(ii) use any window coverings or sunscreen other than Landlord’s standard window coverings, (iii) place any articles on the window sills, (iv) place any items on any exterior balcony, or (v) paint, affix or exhibit any signs
or any kind in the Premises which can be viewed from the exterior of the Premises. Interior signs on doors and the directory tablet, in each case in Building standard form, shall be provided by Landlord at Landlord’s sole cost and expense. 

34. Early Termination Right. Tenant shall have the right, subject to the provisions of this Section 34, to terminate this
Lease (“Termination Right”) with respect to the entire Premises only as of March 31, 2018 (“Early Termination Date”), so long as Tenant delivers to Landlord (i) a written notice (“Termination
Notice”), of its election to exercise its Termination Right no less than 12 months in advance of the Early Termination Date, and (ii) concurrent with Tenant’s delivery of the Termination Notice to Landlord, the unamortized amount
of any outstanding Additional Tenant Improvement Allowance with interest as provided in Section 3(c) above (the “Early Termination Payment”). If Tenant timely and properly exercises the Termination Right, Tenant shall
vacate the Premises and deliver possession thereof to Landlord in the condition required by the terms of this Lease on or before the Early Termination Date and Tenant shall have no further obligations under this Lease except for those accruing prior
to the Early Termination Date and those which, pursuant to the terms of this Lease, survive the expiration or early termination of this Lease. If Tenant does not deliver to Landlord the Termination Notice and the Early Termination Payment within the
time period provided in this paragraph, Tenant shall be deemed to have waived its Termination Right and the provisions of this Section 34 shall have no further force or effect. 

35. Right to Extend Term. Tenant shall have the right to extend the Term of the Lease upon the following terms and conditions: 

(a) Extension Right. Tenant shall have one right (the “Extension Right”) to extend the term of this Lease for 5 years
(the “Extension Term”) on the same terms and conditions as this Lease (other than Base Rent) by giving Landlord written notice of its election to exercise the Extension Right at least 12 months prior to the expiration of the
original Term of the Lease. 

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 Upon the commencement of the Extension Term, Base Rent shall be payable at the Market Rate
(as defined below). Base Rent shall thereafter be adjusted on each annual anniversary of the commencement of such Extension Term by a percentage as determined by Landlord and agreed to by Tenant at the time the Market Rate is determined. As used
herein, “Market Rate” shall mean the then market rental rate for combined laboratory and office space in Kendall Square area of East Cambridge of comparable age, quality, level of finish and proximity to amenities and public
transit, which shall in no event be less than the Base Rent payable as of the date immediately preceding the commencement of the Extension Term. The Market Rate shall initially be determined by Landlord and submitted to Tenant for its consideration.

 If, on or before the date which is 270 days prior to the expiration of the Base Term of this Lease, Tenant has not agreed with
Landlord’s determination of the Market Rate and the rent escalations during the Extension Term after negotiating in good faith, Tenant shall be deemed to have elected arbitration as described in Section 35(b). Tenant acknowledges
and agrees that, if Tenant has elected to exercise the Extension Right by delivering notice to Landlord as required in this Section 35(a), Tenant shall have no right thereafter to rescind or elect not to extend the term of the Lease for
the Extension Term. 
 (b) Arbitration. Within 10 days of Tenant’s notice to Landlord of its election (or deemed election) to
arbitrate Market Rate and escalations, each party shall deliver to the other a proposal containing the Market Rate and escalations that the submitting party believes to be correct (“Extension Proposal”). If either party fails to
timely submit an Extension Proposal, the other party’s submitted proposal shall determine the Base Rent and escalations for the Extension Term. If both parties submit Extension Proposals, then Landlord and Tenant shall meet within 7 days after
delivery of the last Extension Proposal and make a good faith attempt to mutually appoint a single Arbitrator (and defined below) to determine the Market Rate and escalations. If Landlord and Tenant are unable to agree upon a single Arbitrator, then
each shall, by written notice delivered to the other within 10 days after the meeting, select an Arbitrator. If either party fails to timely give notice of its selection for an Arbitrator, the other party’s submitted proposal shall determine
the Base Rent for the Extension Term. The 2 Arbitrators so appointed shall, within 5 business days after their appointment, appoint a third Arbitrator. If the 2 Arbitrators so selected cannot agree on the selection of the third Arbitrator within the
time above specified, then either party, on behalf of both parties, may request such appointment of such third Arbitrator by application to any state court of general jurisdiction in the jurisdiction in which the Premises are located, upon 10 days
prior written notice to the other party of such intent. 
 The decision of the Arbitrator(s) shall be made within 30 days after the
appointment of a single Arbitrator or the third Arbitrator, as applicable. The decision of the single Arbitrator shall be final and binding upon the parties. The average of the two closest Arbitrators in a three Arbitrator panel shall be final and
binding upon the parties. Each party shall pay the fees and expenses of the Arbitrator appointed by or on behalf of such party and the fees and expenses of the third Arbitrator shall be borne equally by both parties. If the Market Rate and
escalations are not determined by the first day of the Extension Term, then Tenant shall pay Landlord Base Rent in an amount equal to the Base Rent in effect immediately prior to the Extension Term and increased by the Rent Adjustment Percentage
until such determination is made. After the determination of the Market Rate and escalations, the parties shall make any necessary adjustments to such payments made by Tenant. Landlord and Tenant shall then execute an amendment recognizing the
Market Rate and escalations for the Extension Term. 
 An “Arbitrator” shall be any person appointed by or on behalf of
either party or appointed pursuant to the provisions hereof and: (i) shall be (A) a member of the American Institute of Real Estate Appraisers with not less than 10 years of experience in the appraisal of improved office and high tech or
life sciences space in the greater Boston metropolitan area, or (B) a licensed commercial real estate broker with not less than 15 years of experience representing landlords and/or tenants in the leasing of improved office and high tech or life
sciences space in the greater Boston metropolitan area, (ii) devoting substantially all of their time to professional appraisal or brokerage work, as applicable, at the time of appointment and (iii) be in all respects impartial and
disinterested. 

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 (c) Rights Personal. The Extension Right is personal to Tenant (and successors
pursuant to a Permitted Assignment) and not assignable without Landlord’s consent, which may be granted or withheld in Landlord’s sole discretion separate and apart from any consent by Landlord to an assignment of Tenant’s interest in
the Lease. 
 (d) Exceptions. Notwithstanding anything set forth above to the contrary, the Extension Right shall, at Landlord’s
option, not be in effect and Tenant may not exercise the Extension Right: 
 (i) during any period of time that Tenant is in
Default under any provision of this Lease; or 
 (ii) if Tenant has been in Default under any provision of this Lease 3 or
more times, whether or not the Defaults are cured, during the 12 month period immediately prior to the date that Tenant intends to exercise the Extension Right, whether or not the Defaults are cured. 

(iii) if Tenant (including any successor pursuant to one or more Permitted Assignment(s)) is not in occupancy of at least 75%
of the entire Premises demised hereunder both at the time of the exercise of the Extension Right and at the time of the commencement date of the Extension Term. 

(e) No Extensions. The period of time within which the Extension Right may be exercised shall not be extended or enlarged by reason of
Tenant’s inability to exercise the Extension Right. 
 (f) Termination. The Extension Right shall, at Landlord’s option,
terminate and be of no further force or effect even after Tenant’s due and timely exercise of the Extension Right, if, after such exercise, but prior to the commencement date of the Extension Term, (i) Tenant fails to timely cure any
default by Tenant under this Lease; or (ii) Tenant has Defaulted 3 or more times during the period from the date of the exercise of the Extension Right to the date of the commencement of the Extension Term, whether or not such Defaults are
cured. 
 36. Miscellaneous. 

(a) Notices. Except as otherwise provided herein, all notices or other communications between the parties shall be in writing and shall
be deemed duly given upon delivery or refusal to accept delivery by the addressee thereof if delivered in person, confirmed receipt by facsimile, or upon delivery if delivered by reputable overnight guaranty courier or certified mail return receipt
requested, addressed and sent to the parties at their addresses set forth above. Landlord and Tenant may from time to time by written notice to the other designate another address for receipt of future notices. 

(b) Recordation. Neither this Lease nor a memorandum of lease shall be filed by or on behalf of Tenant in any public record. Landlord
may prepare and file, and upon request by Landlord Tenant will execute, a memorandum of lease. 
 (c) Interpretation. The normal rule
of construction to the effect that any ambiguities are to be resolved against the drafting party shall not be employed in the interpretation of this Lease or any exhibits or amendments hereto. The captions inserted in this Lease are for convenience
only and in no way define, limit or otherwise describe the scope or intent of this Lease, or any provision hereof, or in any way affect the interpretation of this Lease. 

(d) Not Binding Until Executed. The submission by Landlord to Tenant of this Lease shall have no binding force or effect, shall not
constitute an option for the leasing of the Premises, nor confer any right or impose any obligations upon either party until execution of this Lease by both parties. 

(e) Limitations on Interest. It is expressly the intent of Landlord and Tenant at all times to comply with applicable law governing the
maximum rate or amount of any interest payable on or in 

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connection with this Lease. If applicable law is ever judicially interpreted so as to render usurious any interest called for under this Lease, or contracted for, charged, taken, reserved, or
received with respect to this Lease, then it is Landlord’s and Tenant’s express intent that all excess amounts theretofore collected by Landlord be credited on the applicable obligation (or, if the obligation has been or would thereby be
paid in full, refunded to Tenant), and the provisions of this Lease immediately shall be deemed reformed and the amounts thereafter collectible hereunder reduced, without the necessity of the execution of any new document, so as to comply with the
applicable law, but so as to permit the recovery of the fullest amount otherwise called for hereunder. 
 (f) Choice of Law.
Construction and interpretation of this Lease shall be governed by the internal laws of the state in which the Premises are located, excluding any principles of conflicts of laws. 

(g) Time. Time is of the essence as to the performance of Tenant’s obligations under this Lease. 

(h) Force Majeure. Except for the payment of Rent, neither Landlord nor Tenant shall be held responsible or liable for delays in the
performance of its obligations hereunder when caused by, related to, or arising out of acts of God, strikes, lockouts, or other labor disputes, embargoes, quarantines, weather, national, regional, or local disasters, calamities, or catastrophes,
inability to obtain labor or materials (or reasonable substitutes therefor) at reasonable costs or failure of, or inability to obtain, utilities necessary for performance, governmental restrictions, orders, limitations, regulations, or controls,
national emergencies, delay in issuance or revocation of permits, enemy or hostile governmental action, terrorism, insurrection, riots, civil disturbance or commotion, fire or other casualty, and other causes or events beyond their reasonable
control (individually or collectively, “Force Majeure”), it being understood that Force Majeure shall not include financial difficulties of Landlord, if any. 

(i) Financial Information. Tenant shall furnish Landlord with true and complete copies of (i) Tenant’s most recent audited
annual financial statements within 90 days of the end of each of Tenant’s fiscal years during the Term, (ii) Tenant’s most recent unaudited quarterly financial statements within 45 days of the end of each of Tenant’s first three
fiscal quarters of each of Tenant’s fiscal years during the Term, (iii) corporate brochures and/or profiles prepared by Tenant for prospective investors, and (iv) any other financial information or summaries that Tenant typically
provides to its lenders or shareholders (other than any forward-looking or predictive information). So long as Tenant is a “public company” and its financial information is publicly available, then the foregoing delivery requirements of
this Section 37(i) shall not apply. Notwithstanding the foregoing, in no event shall Tenant be required to provide any financial information to Landlord which Tenant does not otherwise prepare (or cause to be prepared) for its own
purposes. 
 (j) OFAC. Tenant, and all beneficial owners of Tenant, are currently (a) in compliance with, and shall at all times
during the Term of this Lease remain in compliance with, the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any statute, executive order, or regulation relating thereto
(collectively, the “OFAC Rules”), (b) not listed on, and shall not during the Term of this Lease be listed on, the Specially Designated Nationals and Blocked Persons List maintained by OFAC and/or on any other similar list
maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not a person or entity with whom a U.S. person is prohibited from conducting business under the OFAC Rules. 

(k) Incorporation by Reference. All exhibits and addenda attached hereto are hereby incorporated into this Lease and made a part
hereof. If there is any conflict between such exhibits or addenda and the terms of this Lease, such exhibits or addenda shall control, except in the case of conflict between the Rules and Regulations in Exhibit I. In the event of any conflict
between the Rules and Regulations in Exhibit I and the Lease, the Lease shall control. 
 (l) Entire Agreement. This Lease,
including the exhibits attached hereto, constitutes the entire agreement between Landlord and Tenant pertaining to the subject matter hereof and supersedes all prior and contemporaneous agreements, understandings, letters of intent, negotiations and

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discussions, whether oral or written, of the parties, and there are no warranties, representations or other agreements, express or implied, made to either party by the other party in connection
with the subject matter hereof except as specifically set forth herein. 
 (m) No Accord and Satisfaction. No payment by Tenant or
receipt by Landlord of a lesser amount than the monthly installment of Base Rent or any Additional Rent will be other than on account of the earliest stipulated Base Rent and Additional Rent, nor will any endorsement or statement on any check or
letter accompanying a check for payment of any Base Rent or Additional Rent be an accord and satisfaction. Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such Rent or to pursue any
other remedy provided in this Lease. 
 (n) Hazardous Activities. Notwithstanding any other provision of this Lease, Landlord, for
itself and its employees, agents and contractors, reserves the right to refuse to perform any repairs or services in any portion of the Premises which, pursuant to Tenant’s routine safety guidelines, practices or custom or prudent industry
practices, require any form of protective clothing or equipment other than safety glasses. In any such case, Tenant shall contract with parties who are acceptable to Landlord, in Landlord’s reasonable discretion, for all such repairs and
services, and Landlord shall, to the extent required, equitably adjust Tenant’s Share of Operating Expenses in respect of such repairs or services to reflect that Landlord is not providing such repairs or services to Tenant. 

[ Signatures on next page ] 

 215 First/Seres - Page 
 33
 
  

 IN WITNESS WHEREOF, Landlord and Tenant have executed this Lease as of the day and year first
above written. 
  

							
	TENANT:
	
	 SERES HEALTH, INC.,
 a
Delaware corporation

		
	By:		 /s/ Eric Shaff

	Its:		 CFO

	
	LANDLORD:
	
	ARE-MA REGION NO. 38, LLC, a Delaware limited liability company
		
	By:		Alexandria Real Estate Equities, L.P.,
			a Delaware limited partnership, member
			
			By:		ARE-QRS Corp., a Maryland corporation, general partner
				
					By:		 /s/ Eric Johnson

					Its:		 Eric S. Johnson

							Vice President
							Real Estate Legal Affair

 EXHIBIT A TO LEASE 

DESCRIPTION OR PLAN OF PREMISES 
  

 
 

 

 

 

 EXHIBIT B TO LEASE 

DESCRIPTION OR PLAN OF SHARED SCIENCE FACILITY 
  

 

 

 

 EXHIBIT C TO LEASE 

DESCRIPTION OR PLAN OF SHARED CONFERENCE FACILITY 
  

 
 

 

 

 

 EXHIBIT D TO LEASE 

DESCRIPTION OF PROJECT 

A certain parcel of land with the buildings thereon, in Cambridge, Middlesex County, Massachusetts, known as and numbered 215 First Street,
and bounded and described as follows: 
 Beginning at the northwest corner of Athenaeum Street and First Street, said point being the
southeasterly corner of the parcel; 
 Thence running N 80 degrees 12’27” W, a distance of 399.30 feet along the northerly line of
said Athenaeum Street; 
 Thence turning and running N 09 degrees 43’10” E, a distance of 200.00 feet along the easterly line of
Second Street; 
 Thence turning and running S 80 degrees 12’27” E, a distance of 399.41 feet along the southerly line of Munroe
Street; 
 Thence turning and running S 09 degrees 45’06” W, a distance of 200.00 feet along the westerly line of First Street to
the point of beginning. 
 The above described parcel contains 79,871 square feet, more or less. 

 EXHIBIT E TO LEASE 

LICENSE AGREEMENT 

THIS LICENSE AGREEMENT (this “Agreement”), dated as of
            , 2015, is made and entered into by and between ARE-MA REGION NO. 38, LLC, a Delaware limited liability company (“Licensor”), and SERES HEALTH,
INC., a Delaware corporation (“Licensee”), with reference to the following Recitals: 
 RECITALS 

A. Licensor is the owner of that certain property commonly known as 215 First Street, Cambridge, Massachusetts (the
“Property”). 
 B. Concurrently herewith, Licensee and Licensor are entering into that certain Lease Agreement (the
“Lease”) for certain space located at the Property and more particularly described therein (the “Premises”). All initially capitalized terms used herein but not otherwise defined shall have the respective meanings
ascribed thereto in the Lease. 
 C. Licensee desires to have, and Licensor desires to grant to Licensee, certain rights to access
and use a certain area of the Property described as the “Shared Science Facility” on Exhibit 1 attached hereto and a certain area of the Property described as the “Shared Conference Facility” on Exhibit
2 attached hereto, all in accordance with the terms and provisions set forth below. 
 AGREEMENT 

For and in consideration of the covenants and premises herein contained and other good and valuable consideration, the receipt and sufficiency
of which are hereby acknowledged, the parties hereby agree as follows: 
 1. License; Scheduling and Fees for Shared Conference Facility. 

(a) License. Licensor hereby grants Licensee, and Licensee hereby accepts, a non-exclusive license to use the Shared Science
Facility and the Shared Conference Facility subject to the terms and provisions of this Agreement. 
 (b) Scheduling and Fees for
Shared Conference Facility. Use by Licensee of the Shared Conference Facility shall be in common with others entitled to use the Shared Conference Facility in accordance with scheduling procedures reasonably determined by Licensor. Licensor
shall use commercially reasonable efforts to schedule users on a first-come, first-served basis, but Licensor reserves the right to exercise its discretion in the event of conflicting scheduling requests among users. The first two occasions in a
calendar month that Licensee uses the Shared Conference Facility shall be at no charge for such use, and thereafter Licensee shall pay the hourly charges established by Licensor from time to time for use of the Shared Conference Facility. The
current hourly charge for the use of the Shared Conference Facility as of the date of this Lease is $200 per hour and is subject to change as determined by Licensor from time to time. Payment of such hourly charges shall be made within 20 days of
invoice therefor, and Licensor reserves the right to require an advance deposit from time to time. 
 2. Use. Licensee shall exercise its
limited rights hereunder in compliance with all laws, orders, judgments, ordinances, regulations, codes, directives, permits, licenses, covenants and restrictions now or hereafter applicable to the Property, Shared Science Facility or Shared
Conference Facility and the use and occupancy thereof, including the rules and regulations attached as Exhibit 3 hereto, as the same may be revised by Licensor from time to time. 

 3. Term. The term of this Agreement shall commence on the Commencement Date set forth in the Lease
(the “Commencement Date”) and continue until the earlier to occur of (a) the last day on which Licensee is entitled to occupy the Premises pursuant to the terms of the Lease, (b) the date this Agreement is sooner
terminated pursuant to its terms, and (c) the date the Lease is sooner terminated pursuant to its terms. The period between the Commencement Date and the date of termination of this Agreement shall be the “Term.” 

4. Relocation and Modification of Shared Science Facility or Shared Conference Facility. Licensor shall have the right at any time to
reconfigure, relocate or modify the Shared Science Facility and/or Shared Conference Facility from time to time and to revise or expand any of the services (if any) provided therein; provided, however, that such reconfiguration, relocation or
modification of the respective facility or any revision or expansion of services shall not materially adversely affect Tenant’s use of such facility or service as permitted pursuant to this Agreement. 

5. Interference. Licensee shall use the Shared Science Facility and Shared Conference Facility in a manner that will not interfere with the
rights of any tenants, other licensees or Licensor’s service providers. Licensor assumes no responsibility for enforcing Licensee’s rights or for protecting the Shared Science Facility or Shared Conference Facility from interference or use
from any person, including, without limitation, tenants or other licensees of the Property. 
 6. Default by Licensee. 

(a) It is mutually agreed that Licensee shall be in default hereunder (“Default”), 

(i) if Licensee fails to comply with any of the terms or provisions of this Agreement, and fails to cure such default within 30
days after the date of delivery of written notice of default from Licensor, provided that if the nature of such default is such that it cannot be cured by the payment of money and reasonably requires more than 30 days to cure, then Licensee shall
not be deemed to be in Default under this License if Licensee commences such cure within 30 days of the aforesaid notice from Licensor and thereafter diligently prosecutes such cure to completion within 90 days of the aforesaid notice from Licensor;
or 
 (ii) with respect to the Shared Conference Facility, if Licensee fails to pay any fees or charges for use of the Shared
Conference Facility or other amounts required hereunder when due pursuant to this Agreement; provided, however, that Licensor will give Licensee notice and an opportunity to cure any failure to pay such fees or charges within 3 business days of any
such notice not more than once in any 12 month period and Licensee agrees that such notice shall be in lieu of and not in addition to, or shall be deemed to be, any notice required by law or 

(iii) during the occurrence and continuation of any Default (as defined in the Lease) under the Lease. 

(b) In the event of any Default by Licensee hereunder, Licensor shall be entitled to all rights and remedies provided for Landlord under the
Lease, and all other rights and remedies provided at law or in equity, including without limitation, termination of this Agreement and the license granted hereunder. 

7. Indemnification and Limitation of Liability. 

(a) Licensor’s sole obligation for providing standby generators or any other standby power equipment, other equipment, systems,
furnishings or personal property to the Shared Science Facility or Shared Conference Facility, whether or not affixed to the Building (collectively, “Equipment”) shall be (i) to provide such Equipment as is determined by
Licensor in its sole and absolute discretion, and (ii) to contract with a third party (determined by Licensor to be qualified) to maintain the Equipment that is deemed by Licensor (in its reasonable professional discretion) to need periodic
maintenance per the manufacturer’s standard maintenance guidelines. Licensor shall have no obligation to provide Licensee with operational Equipment, back-up Equipment or back-up utilities or to supervise, oversee or confirm

 
that the third party maintaining the Equipment is maintaining the Equipment as per the manufacturer’s standard guidelines or otherwise. During any period of replacement, repair or
maintenance of the Equipment when such Equipment is not operational, including any delays thereto due to the inability to obtain parts or replacements, Licensor shall have no obligation to provide Licensee with alternative or back-up Equipment or
alternative sources of utilities. Licensee expressly acknowledges and agrees that Licensor does not guaranty that the Equipment will be operational at all times, will function or perform adequately, or that emergency power will be available to the
Premises when needed, and Licensor shall not be liable for any damages resulting from the failure of such Equipment. Licensee hereby releases Licensor from and against any and all claims arising directly or indirectly out of or relating to the
Equipment, or the existence, use of failure thereof, unless caused solely by the willful misconduct or gross negligence of Licensor. The terms and provisions of this Section 7(a) shall survive the expiration or earlier termination of
this Agreement. 
 (b) NOTWITHSTANDING ANYTHING SET FORTH HEREIN OR IN ANY OTHER AGREEMENT BETWEEN LICENSOR AND LICENSEE TO THE CONTRARY:
(i) LICENSOR SHALL NOT BE LIABLE TO LICENSEE OR ANY OTHER PERSON FOR (AND LICENSEE AND EACH SUCH OTHER PERSON ASSUME ALL RISK OF) LOSS, DAMAGE OR INJURY, WHETHER ACTUAL OR CONSEQUENTIAL TO PERSONAL PROPERTY OF EVERY KIND AND DESCRIPTION,
INCLUDING, WITHOUT LIMITATION, TRADE FIXTURES, EQUIPMENT, INVENTORY, SCIENTIFIC RESEARCH, SCIENTIFIC EXPERIMENTS, LABORATORY ANIMALS, PRODUCT, SPECIMENS, SAMPLES, AND/OR SCIENTIFIC, BUSINESS, ACCOUNTING AND OTHER RECORDS OF EVERY KIND AND
DESCRIPTION AND ANY AND ALL INCOME DERIVED OR DERIVABLE THEREFROM; and (ii) THERE SHALL BE NO PERSONAL RECOURSE TO LICENSOR FOR ANY ACT OR OCCURRENCE IN, ON OR ABOUT THE PREMISES, SHARED SCIENCE FACILITY, SHARED CONFERENCE FACILITY OR PROJECT
OR ARISING IN ANY WAY UNDER THIS LICENSE AGREEMENT OR ANY OTHER AGREEMENT BETWEEN LICENSOR AND LICENSEE WITH RESPECT TO THE SUBJECT MATTER HEREOF AND ANY LIABILITY OF LICENSOR HEREUNDER SHALL BE STRICTLY LIMITED SOLELY TO LICENSOR’S INTEREST IN
THE PROJECT OR ANY PROCEEDS FROM SALE OR CONDEMNATION THEREOF AND ANY INSURANCE PROCEEDS PAYABLE IN RESPECT OF LICENSOR’S INTEREST IN THE PROJECT OR IN CONNECTION WITH ANY SUCH LOSS; AND (iii) IN NO EVENT SHALL ANY PERSONAL LIABILITY BE
ASSERTED AGAINST LICENSOR OR ANY OF ITS OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS IN CONNECTION WITH THIS LICENSE AGREEMENT NOR SHALL ANY RECOURSE BE HAD TO ANY OTHER PROPERTY OR ASSETS OF LICENSOR OR ANY OF LICENSOR’S OFFICERS,
DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS. 
 (c) Licensee acknowledges and agrees that there are no warranties of any kind, whether
express or implied, made by Licensor or otherwise with respect to the Shared Science Facility, Shared Conference Facility or any services (if any) provided in either the Shared Science Facility or Shared Conference Facility, and Licensee disclaims
any and all such warranties. 
 (d) Licensor shall not be in default hereunder unless Licensor fails to perform any of its obligations
hereunder within thirty (30) days after written notice from Licensee specifying such failure, with such extension of time by reason of Force Majeure as may be reasonably necessary; provided, however, that if the nature of Licensor’s
obligation arises from an emergency condition and Licensee provides notice to Licensor (which may be telephonic if followed by written notice on the same day describing the emergency condition in reasonable detail, including without limitation the
emergency nature of the condition and specifying in all capital letters and boldface type that the condition is an emergency and response is required by Licensor pursuant to this Agreement), then Licensor shall respond within a reasonable period
after receipt of such notice of the emergency condition. Licensee’s sole remedy for any breach or default by Licensor hereunder shall be to terminate this Agreement and Licensee hereby, to the maximum extent possible, knowingly waives the
provisions of any law or regulation, now or hereafter in effect which provides additional or other remedies to Licensee as a result of any breach by Licensor hereunder or under any such law or regulation. 

 8. Miscellaneous. 

(a) This Agreement, together with the Lease, constitutes the entire agreement and understanding between the parties, and supersedes all offers,
negotiations and other agreements concerning the subject matter contained herein. Any amendments to this Agreement must be in writing and executed by both parties. 

(b) If any clause or provision of this Agreement is illegal, invalid or unenforceable under present or future laws, then and in that event, it
is the intention of the parties hereto that the remainder of this Agreement shall not be affected thereby. 
 (c) This Agreement shall be
binding on and inure to the benefit of the successors and permitted assigns of the respective parties. 
 (d) All notices or other
communications between the parties shall be in writing and shall be deemed duly given upon delivery or refusal to accept delivery by the addressee thereof if delivered in person, or upon actual receipt if delivered by reputable overnight guaranty
courier, addressed and sent to the parties at their addresses set forth in the Lease (as the same may be revised from time to time in accordance with the terms of the Lease). 

(e) The license granted hereunder is appurtenant to Licensee’s leasehold interest in the Premises and may not be assigned or otherwise
pledged or transferred, directly or indirectly, except in connection with any assignment of the Lease or sublease of the Premises to which Landlord consents or is otherwise permitted under the Lease. In the event of a permitted assignment of the
Lease, this Agreement shall automatically be assigned thereby, and thereupon the assigning Licensee shall have no further rights to use or access the Shared Science Facility or Shared Conference Facility. No assignment or other transfer of the Lease
or of this License shall release Licensee of its obligations hereunder. 
 (f) This Agreement shall be construed, interpreted, governed and
enforced pursuant to the laws of the state in which the Property is located. 
 (g) This Agreement may be executed in multiple counterparts
but all counterparts taken together shall constitute a single document. 
 (h) Time is of the essence of each and every provision of this
Agreement. 
 (i) The parties to this Agreement hereby acknowledge that each such party and its counsel have participated in the negotiation
and preparation of this Agreement, and this Agreement shall be construed and interpreted without regard to any presumption or other rule requiring construction against the party causing the Agreement to be drafted. 

(j) Licensee acknowledges that its use of the Shared Science Facility and Shared Conference Facility are non-exclusive and will be subject to
the use of other tenants and licensees of the Property. Licensee acknowledges that it will be important for all such users to cooperate with each other to maintain the confidentiality of each party’s documents and operations as well as
information a party may hold under confidential arrangements with third parties. Licensee shall maintain and treat as confidential and secret all information and materials which may intentionally or unintentionally be disclosed to it in connection
with such shared occupancy (the “Confidential Information”). Licensee shall not disclose Confidential Information to any third party and will take appropriate action by instruction, agreement or otherwise with its employees, agents,
affiliates, associates, representatives, contractors and invitees to ensure that security of the Confidential Information is maintained. Notwithstanding the foregoing, Licensee may disclose Confidential Information to the extent that
(a) disclosure is compelled by judicial or administrative process or other requirements of law, or (b) Licensee can show that such Confidential Information (i) was publicly available prior to the date of this Agreement or thereafter
became publicly available without violation of this Agreement by Licensee or its employees, agents, affiliates, associates, representatives, contractors or invitees, or (ii) became available to Licensee by means other

 
than its use of or access to the Shared Science Facility or Shared Conference Facility. The provisions of this Section 8(j) shall survive the expiration or earlier termination of this
Agreement. 
 [Signatures On Next Page] 

 IN WITNESS WHEREOF, Licensor and Licensee have caused this Agreement to be executed by
their duly authorized representatives as of the date first above written. 
  

							
	LICENSEE:
	
	 SERES HEALTH, INC.,
 a
Delaware corporation

		
	By:		 /s/ Eric Shaff

	Its:		CFO
	
	LICENSOR:
	
	ARE-MA REGION NO. 38, LLC, a Delaware limited liability company
		
	By:		Alexandria Real Estate Equities, L.P.,
			a Delaware limited partnership, member
			
			By:		ARE-QRS Corp., a Maryland corporation, general partner
				
					By:		 /s/ Eric Johnson

					Its:		Eric Johnson
							Senior Vice President
							RE Legal Affairs

 EXHIBIT 1 TO LICENSE AGREEMENT 

DESCRIPTION OR PLAN OF SHARED SCIENCE FACILITY 
  

 
 

 

  
 

 

 EXHIBIT 2 TO LICENSE AGREEMENT 

DESCRIPTION OR PLAN OF SHARED CONFERENCE FACILITY 
  

 
 

 

 

 

 EXHIBIT 3 TO LICENSE AGREEMENT 

RULES AND REGULATIONS 
 Rules and
regulations (if any) will be established and implemented by Licensor during the Term. 

 215 First/Seres - Page 1 

 

 EXHIBIT F TO LEASE 

TENANT IMPROVEMENTS PLANS 
  

 

 215 First/Seres - Page 1 

 

 EXHIBIT G TO LEASE 

ACKNOWLEDGMENT OF COMMENCEMENT DATE 

This ACKNOWLEDGMENT OF COMMENCEMENT DATE is made this 7th day of April, 2015 between ARE-MA REGION NO. 38, LLC, a Delaware
limited liability company (“Landlord”), and SERES HEALTH, INC., a Delaware corporation (“Tenant”), and is attached to and made a part of the Lease dated April 6, 2015 (the
“Lease”), by and between Landlord and Tenant. Any initially capitalized terms used but not defined herein shall have the meanings given them in the Lease. 

Landlord and Tenant hereby acknowledge and agree, for all purposes of the Lease, that the Commencement Date of the Base Term of the Lease is
April 7, 2015 and the termination date of the Base Term of the Lease shall be midnight on April 30, 2020. In case of a conflict between this Acknowledgment of Commencement Date and the Lease, this Acknowledgment of Commencement Date shall
control for all purposes. 
 IN WITNESS WHEREOF, Landlord and Tenant have executed this ACKNOWLEDGMENT OF COMMENCEMENT DATE to be effective
on the date first above written. 
  

							
	TENANT:
	
	 SERES HEALTH, INC.,
 a
Delaware corporation

		
	By:		 /s/ Eric Shaff

	Its:		CFO
	
	LANDLORD:
	
	ARE-MA REGION NO. 38, LLC, a Delaware limited liability corporation
		
	By:		Alexandria Real Estate Equities, L.P.,
			a Delaware limited partnership, member
			
			By:		ARE-QRS Corp., a Maryland corporation, general partner
				
					By:		 /s/ Eric Johnson

					Its:		Eric Johnson
							Senior Vice President
							RE Legal Affairs

 215 First/Seres - Page 1 

 

 EXHIBIT H TO LEASE 

TENANT’S PERSONAL PROPERTY 

None. 

			
	Rules and Regulations		215 First/Seres - Page 1

  

 EXHIBIT I TO LEASE 

Rules and Regulations 

1. The sidewalk, entries, and driveways of the Project shall not be obstructed by Tenant, or any Tenant Party, or used by them for any purpose
other than ingress and egress to and from the Premises. 
 2. Tenant shall not place any objects, including antennas, outdoor furniture,
etc., in the parking areas, landscaped areas or other areas outside of its Premises, or on the roof of the Project. 
 3. Except for animals
assisting the disabled, no animals shall be allowed in the offices, halls, or corridors in the Project. 
 4. Tenant shall not disturb the
occupants of the Project or adjoining buildings by the use of any radio or musical instrument or by the making of loud or improper noises. 

5. If Tenant desires telegraphic, telephonic or other electric connections in the Premises, Landlord or its agent will direct the electrician
as to where and how the wires may be introduced; and, without such direction, no boring or cutting of wires will be permitted. Any such installation or connection shall be made at Tenant’s expense. 

6. Tenant shall not install or operate any steam or gas engine or boiler, or other mechanical apparatus in the Premises, except as
specifically approved in the Lease. The use of oil, gas or inflammable liquids for heating, lighting or any other purpose is expressly prohibited. Explosives or other articles deemed extra hazardous shall not be brought into the Project. 

7. Parking any type of recreational vehicles is specifically prohibited on or about the Project. Except for the overnight parking of operative
vehicles, no vehicle of any type shall be stored in the parking areas at any time. In the event that a vehicle is disabled, it shall be removed within 48 hours. There shall be no “For Sale” or other advertising signs on or about any parked
vehicle. All vehicles shall be parked in the designated parking areas in conformity with all signs and other markings. All parking will be open parking, and no reserved parking, numbering or lettering of individual spaces will be permitted except as
specified by Landlord. 
 8. Tenant shall maintain the Premises free from rodents, insects and other pests. 

9. Landlord reserves the right to exclude or expel from the Project any person who, in the judgment of Landlord, is intoxicated or under the
influence of liquor or drugs or who shall in any manner do any act in violation of the Rules and Regulations of the Project. 
 10. Tenant
shall not cause any unnecessary labor by reason of Tenant’s carelessness or indifference in the preservation of good order and cleanliness. Landlord shall not be responsible to Tenant for any loss of property on the Premises, however occurring,
or for any damage done to the effects of Tenant by the janitors or any other employee or person. 
 11. Tenant shall give Landlord prompt
notice of any defects in the water, lawn sprinkler, sewage, gas pipes, electrical lights and fixtures, heating apparatus, or any other service equipment affecting the Premises. 

12. Tenant shall not permit storage outside the Premises, including without limitation, outside storage of trucks and other vehicles, or
dumping of waste or refuse or permit any harmful materials to be placed in any drainage system or sanitary system in or about the Premises. 

			
	Rules and Regulations		215 First/Seres - Page 2

  

 13. All moveable trash receptacles provided by the trash disposal firm for the Premises must
be kept in the trash enclosure areas, if any, provided for that purpose. 
 14. No auction, public or private, will be permitted on the
Premises or the Project. 
 15. No awnings shall be placed over the windows in the Premises except with the prior written consent of
Landlord. 
 16. The Premises shall not be used for lodging, sleeping or cooking (except that Tenant may use microwave ovens, toasters and
coffee makers in the Premises for the benefit of Tenant’s employees and contractors in an area designated for such items, but only if the use thereof is at all times supervised by the individual using the same) or for any immoral or illegal
purposes or for any purpose other than that specified in the Lease. No gaming devices shall be operated in the Premises. 
 17. Tenant shall
ascertain from Landlord the maximum amount of electrical current which can safely be used in the Premises, taking into account the capacity of the electrical wiring in the Project and the Premises and the needs of other tenants, and shall not use
more than such safe capacity. Landlord’s consent to the installation of electric equipment shall not relieve Tenant from the obligation not to use more electricity than such safe capacity. 

18. Tenant assumes full responsibility for protecting the Premises from theft, robbery and pilferage. 

19. Tenant shall not install or operate on the Premises any machinery or mechanical devices of a nature not directly related to Tenant’s
ordinary use of the Premises and shall keep all such machinery free of vibration, noise and air waves which may be transmitted beyond the Premises. 

 215 First/Seres - Page 1 

 

 EXHIBIT J TO LEASE 

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS 

This notification provides certain information about asbestos within or about the Premises at 215 First Street, Cambridge, MA (“Building”).

 Historically, asbestos was commonly used in building products used in the construction of buildings across the country.
Asbestos-containing building products were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still
sometimes found in buildings today. 
 No ACMs were identified in an asbestos survey of the building conducted in 2007. However, to avoid damage, several
materials were not sampled and are presumed asbestos-containing materials or PACMs as listed in the following table: 
  

			
	 Material Description
	 	 Material Location

	Ceramic tile adhesive and grout	 	Throughout restrooms; ground floor hallways;
first floor lobby and hallways
	Built-up roofing beneath rubber	 	Throughout roof
	Flashing cement	 	Roof
	Flex connectors on HVAC units	 	Roof

 The PACMs described above were observed to be in good condition and may be managed in place. Because ACMs may be present
within or about the Building, we have hired an independent environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful
asbestos exposure to any person within or about the Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant
disturbance of such ACMs or PACMs. Appropriate personnel receive regular periodic training on how to properly administer the O&M Program. 
 The O&M
Program describes the risks associated with asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the
air and inhaled. This does not typically occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If
inhaled, asbestos fibers can accumulate in the lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers,
reduce the risks of adverse health effects. 
 The O&M Program describes a number of activities that should be avoided in order to prevent a release of
asbestos fibers. In particular, you should be aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not
qualified to handle ACMs. 
 The O&M Program is available for review during regular business hours at Landlord’s office located at 400 Technology
Square, Suite 101, Cambridge, MA 02139. 

 215 First/Seres - Page 1 

 

 EXHIBIT K TO LEASE 

FURNITURE 
 Open office
area: 
 1 reception desk 
 8 work station desks 

Conference room: 
 1 large table 

12 chairs 
 Office 1 

1 small table 
 4 chairs 

Office 2 
 1 small table 

5 chairs 
 Office 3 

1 small table 
 4 chairs 

Office 4 
 1 small table 

4 chairs 
 Lab: 

8 Lab chairs 
 2 small portable tables in the TC lab 

 215 First/Seres - Page 1 

 

 EXHIBIT L TO LEASE 

EQUIPMENT PLANSEX-10.14

 Exhibit 10.14 

SERIES D PREFERRED STOCK PURCHASE AGREEMENT 

THIS SERIES D PREFERRED STOCK PURCHASE AGREEMENT is made as of the 19th day of December, 2014 by and between Seres Health, Inc., a
Delaware corporation (the “Company”), and Nestlé Health Science US Holdings, Inc., a Delaware corporation (the “Purchaser”). 

The parties hereby agree as follows: 

1. Purchase and Sale of Preferred Stock. 

1.1. Sale and Issuance of Series D and Series D-1 Preferred Stock. 

(a) The Company shall adopt and file with the Secretary of State of the State of Delaware on or before the Closing (as defined below)
the Amended and Restated Certificate of Incorporation in the form of Exhibit A attached to this Agreement (the “Restated Certificate”). 

(b) Subject to the terms and conditions of this Agreement, at the Closing, the Purchaser agrees to purchase from the Company and the
Company agrees to sell and issue to the Purchaser 2,222,222 shares of Series D Preferred Stock, $0.001 par value per share (the “Series D Preferred Stock”), and 1,388,889 shares of Series D-1 Preferred Stock, $0.001 par value per
share (the “Series D-1 Preferred Stock”), in each case at a purchase price of $18.00 per share (the “Purchase Price”). The shares of Series D Preferred Stock and Series D-1 Preferred Stock sold under this Agreement
are referred to collectively as the “Shares.” All the transactions set forth herein to be taken at the Closing, including the delivery of documents, shall be deemed to take place simultaneously at the Closing. 

1.2. Closing; Delivery. 

(a) Closing. Subject to the terms and conditions of this Agreement, including the closing conditions set forth in Sections 4
and 5, the closing of the sale and purchase of the Shares (the “Closing”) shall take place remotely via the exchange of documents and signatures, on the date of this Agreement (the “Closing Date”). At the
Closing, the Company will sell and issue to the Purchaser, and the Purchaser will purchase, the Shares at a price per share equal to the Purchase Price. 

(b) Closing Deliverables. At the Closing, the Company shall deliver to the Purchaser certificates representing the Shares being
purchased by the Purchaser at the Closing against payment of the purchase price therefor by wire transfer of immediately available funds to a bank account designated by the Company. 

1.3. Use of Proceeds. In accordance with the directions of the Board of Directors of the Company (the “Board”), as it
shall be constituted in accordance with the Voting Agreement, the Company will use the proceeds from the sale of the Shares for product development and other general corporate purposes. 

 1.4. Defined Terms Used in this Agreement. In addition to the terms defined above, the
following terms used in this Agreement shall be construed to have the meanings set forth or referenced below. 
 (a)
“Affiliate” means, with respect to any specified Person, any other Person who, directly or indirectly, controls, is controlled by, or is under common control with such Person, including, without limitation, any general partner,
managing member, officer or director of such Person or any venture capital fund now or hereafter existing that is controlled by one or more general partners or managing members of, or shares the same management company with, such Person. 

(b) “Code” means the United States Internal Revenue Code of 1986, as amended. 

(c) “Company Covered Person” means, with respect to the Company as an “issuer” for purposes of Rule 506
promulgated under the Securities Act, any Person described in the first paragraph of Rule 506(d)(1). 
 (d) “Company
Intellectual Property” means the Intellectual Property owned by or licensed to the Company and incorporated in, underlying or used in connection with the Product Candidates or the Internal Systems. 

(e) “Company Notice” means written notice from the Company notifying the Purchaser that the Company is exercising its
Right of First Refusal as to some or all of the Transfer Stock with respect to any Proposed Purchaser Transfer. 
 (f)
“Intellectual Property” means all: (A) patents, patent applications, patent disclosures and all related continuation, continuation-in-part, divisional, reissue, reexamination, utility model, certificate of invention and design
patents, patent applications, registrations and applications for registrations; (B) trademarks, service marks, trade dress, Internet domain names, logos, trade names and corporate names and registrations and applications for registration
thereof; (C) copyrights and registrations and applications for registration thereof; (D) computer software, data and documentation; (E) inventions, trade secrets and confidential business information, whether patentable or
nonpatentable and whether or not reduced to practice, know-how, manufacturing and product processes and techniques, research and development information, copyrightable works, financial marketing and business data, pricing and cost information,
business and marketing plans and customer and supplier lists and information; (F) other proprietary rights relating to any of the foregoing (including remedies against infringements thereof and rights of protection of interest therein under the
laws of all jurisdictions); and (G) copies and tangible embodiments thereof. 
 (g) “Internal Systems”
means the internal systems of the Company that are used in its business or operations, including, computer hardware systems, software applications and embedded systems. 

  
 2 

 (h) “Investors’ Rights Agreement” means the agreement among the
Company and the Purchaser and certain other stockholders of the Company dated as of the date of the Closing, in the form of Exhibit C attached to this Agreement. 

(i) “IPO” means the Company’s first underwritten public offering of its Common Stock under the Securities Act. 

(j) “Key Employee” means any executive-level employee (including vice president-level positions) as well as any
employee or consultant who either alone or in concert with others develops, invents, programs or designs any Company Intellectual Property. 

(k) “Knowledge,” including the phrase “to the Company’s knowledge,” shall mean the actual knowledge
after reasonable investigation of Roger Pomerantz, John Aunins, David Cook and Matthew Henn. 
 (l) “Material Adverse
Effect” means a material adverse effect on the business, assets (including intangible assets), liabilities, financial condition, property, prospects or results of operations of the Company. 

(m) “Person” means any individual, corporation, partnership, trust, limited liability company, association or other
entity. 
 (n) “Product Candidates” means (A) the therapeutic, pharmaceutical and/or drug products that
the Company (1) currently develops, manufactures, markets, sells or licenses or (2) currently plans to develop, manufacture, market, sell or license in the future and (B) the services that the Company (1) currently provides or
(2) currently plans to provide in the future. 
 (o) “Proposed Purchaser Transfer” means any
assignment, sale, offer to sell, pledge, mortgage, hypothecation, encumbrance, disposition of or any other like transfer or encumbering of any Transfer Stock (or any interest therein) proposed by the Purchaser. 

(p) “Proposed Transfer Notice” means written notice from the Purchaser setting forth the material terms and
conditions of a Proposed Purchaser Transfer (including price and form of consideration), the identity of the Prospective Transferee and the intended closing date of the Proposed Purchaser Transfer. 

(q) “Prospective Transferee” means any person to whom the Purchaser proposes to make a Proposed Purchaser Transfer. 

(r) “Purchased Common Shares” means the shares of Common Stock purchased by the Purchaser pursuant to that certain
Stock Purchase Agreement, dated as of December 19, 2014, by and between Flagship VentureLabs IV LLC and the Purchaser. 

(s) “Representatives” means, as to any Person, such Person’s Affiliates, and its and their respective directors,
officers, employees, managing members, general partners, agents and consultants (including attorneys, financial advisors and accountants). 

  
 3 

 (t) “Right of First Refusal” means the right, but not an obligation, of
the Company, or its permitted transferees or assigns, to purchase all of the Transfer Stock in accordance with Section 6. 

(u) “Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated
thereunder. 
 (v) “Tax” or “Taxes” means (i) any foreign, federal, state or local
income, gross receipts, license, payroll, employment, excise, severance, stamp, occupation, premium, property, windfall, profits, environmental, customs, capital stock, franchise, employees’ income withholding, foreign or domestic withholding,
social security, unemployment, disability, real property, personal property, sales, use, transfer, value added, alternative or add-on minimum or other similar tax, governmental fee, governmental assessment or governmental charge, including any
interest, penalties or additions to tax or additional amounts with respect to the foregoing, and (ii) any liability for the payment of any amounts of the type described in the immediately preceding clause (i) as a result of being a member
of an affiliated, combined, consolidated or unitary group for any period, as a result of any tax sharing or tax allocation agreement, arrangement or understanding, or as a result of being liable for another Person’s taxes as a transferee or
successor, by contractual obligation or otherwise. 
 (w) “Tax Return” means any return, declaration,
report, estimate, claim for refund or information return or statement relating to Taxes, including any schedule or attachment thereto, and including any amendment thereof. 

(x) “Transaction Agreements” means this Agreement, the Investors’ Rights Agreement and the Voting Agreement. 

(y) “Transfer Stock” means the Shares, the Purchased Common Shares, the shares of Common Stock (as defined below) or
Series D Preferred Stock, as applicable, issuable upon conversion of the Shares or upon conversion of the Series D Preferred Stock issued upon conversion of the Series D-1 Preferred Stock and any shares of capital stock of the Company issued to the
Purchaser after the date hereof in connection with any stock dividend, stock split, combination or other similar recapitalization with respect to the Shares, the Purchased Common Shares or the shares of Common Stock or Series D Preferred Stock, as
applicable, issuable upon the conversion of the Shares or upon conversion of the Series D Preferred Stock issued upon conversion of the Series D-1 Preferred Stock. 

(z) “Voting Agreement” means the agreement among the Company, the Purchaser and certain other stockholders of the
Company, dated as of the date of the Closing, in the form of Exhibit D attached to this Agreement. 
 2. Representations
and Warranties of the Company. The Company hereby represents and warrants to the Purchaser that, except as set forth on the Disclosure Schedule attached as Exhibit B to this Agreement, which exceptions shall be deemed to be part of the
representations and warranties made hereunder, the following representations are true and complete as of the date of the Closing, except as otherwise indicated. The Disclosure Schedule shall be arranged in sections corresponding to the numbered and
lettered sections and 

  
 4 

 
subsections contained in this Section 2, and the disclosures in any section or subsection of the Disclosure Schedule shall qualify other sections and subsections in this
Section 2 only to the extent it is readily apparent from a reading of the disclosure that such disclosure is applicable to such other sections and subsections. 

For purposes of these representations and warranties (other than those in Subsections 2.2, 2.3, 2.4, 2.5, and
2.6), the term “the Company” shall include any subsidiaries of the Company, unless otherwise noted herein. 
 2.1.
Organization, Good Standing, Corporate Power and Qualification. The Company is a corporation duly organized, validly existing and in good standing under the laws of the State of Delaware and has all requisite corporate power and authority to
carry on its business as presently conducted and as proposed to be conducted. The Company is duly qualified to transact business and is in good standing in each jurisdiction in which the failure to so qualify would have a Material Adverse Effect.

 2.2. Capitalization. 

(a) The authorized capital of the Company consists, immediately prior to the Closing, of: 

(i) 38,000,000 shares of common stock, $0.001 par value per share (the “Common Stock”), 6,890,750 shares of which are
issued and outstanding immediately prior to the Closing. All of the outstanding securities of the Company have been duly authorized, are fully paid and nonassessable and were issued in compliance with all applicable federal and state securities
laws. The Company holds no Common Stock in its treasury. 
 (ii) 24,348,003 shares of Preferred Stock, of which (A) 8,230,997
shares have been designated Series A Preferred Stock, all of which are issued and outstanding immediately prior to the Closing, (B) 2,339,319 shares have been designated Series A-2 Preferred Stock, 2,247,192 of which are issued and outstanding
immediately prior to the Closing, (C) 4,831,359 shares have been designated Series B Preferred Stock, all of which are issued and outstanding immediately prior to the Closing, (D) 3,946,328 shares have been designated Series C Preferred
Stock, all of which are issued and outstanding immediately prior to the Closing, (E) 3,611,111 shares have been designated Series D Preferred Stock, none of which is issued or outstanding immediately prior to the Closing, and (F) 1,388,889
shares have been designated Series D-1 Preferred Stock, none of which is issued or outstanding immediately prior to the Closing. The rights, privileges and preferences of the Preferred Stock are as stated in the Restated Certificate and as provided
by the Delaware General Corporation Law. The Company holds no Preferred Stock in its treasury. 
 (b) The Company has reserved
3,608,029 shares of Common Stock for issuance to officers, directors, employees and consultants of the Company pursuant to its 2012 Stock Incentive Plan duly adopted by the Board and approved by the Company’s stockholders (as amended, the
“Stock Plan”). Options to purchase all of such shares have been granted and are currently outstanding under the Stock Plan or have been exercised for shares for Common Stock. The Company has made available to the Purchaser
complete and accurate copies of the Stock Plan and forms of agreements used thereunder. 

  
 5 

 (c) Subsection 2.2(c) of the Disclosure Schedule sets forth the capitalization of the
Company immediately following the Closing including the number of shares of the following: (i) issued and outstanding Common Stock, including, with respect to restricted Common Stock, vesting schedule and repurchase price; (ii) granted
stock options, including vesting schedule and exercise price; (iii) shares of Common Stock reserved for future award grants under the Stock Plan; (iv) each series of Preferred Stock; and (v) warrants or stock purchase rights, if any.
Except for (A) the conversion privileges of the Shares to be issued under this Agreement, (B) the rights provided in Section 4 of the Investors’ Rights Agreement, and (C) the securities and rights described in
Subsection 2.2(b) of this Agreement and Subsection 2.2(c) of the Disclosure Schedule, there are no outstanding options, warrants, rights (including conversion or preemptive rights and rights of first refusal or similar rights) or
agreements, orally or in writing, to purchase or acquire from the Company any shares of Common Stock or Preferred Stock, or any securities convertible into or exchangeable for shares of Common Stock or Preferred Stock. All outstanding shares of the
Company’s Common Stock and all shares of the Company’s Common Stock underlying outstanding options are subject to (i) a right of first refusal in favor of the Company upon any proposed transfer (other than transfers for estate
planning purposes); and (ii) a lock-up or market standoff agreement of not less than 180 days following the Company’s initial public offering pursuant to a registration statement filed with the Securities and Exchange Commission under the
Securities Act. 
 (d) None of the Company’s stock purchase agreements or stock option documents contains a provision for acceleration
of vesting (or lapse of a repurchase right) or other changes in the vesting provisions or other terms of such agreement or understanding upon the occurrence of any event or combination of events, including without limitation in the case where the
Stock Plan is not assumed in an acquisition. The Company has never adjusted or amended the exercise price of any stock options previously awarded, whether through amendment, cancellation, replacement grant, repricing, or any other means. Except as
set forth in the Restated Certificate, the Company has no obligation (contingent or otherwise) to purchase or redeem any of its capital stock. 

(e) 409A. The Company believes in good faith that any “nonqualified deferred compensation plan” (as such term is
defined under Section 409A(d)(1) of the Code and the guidance thereunder) under which the Company makes, is obligated to make or promises to make, payments (each, a “409A Plan”) complies in all material respects, in both form
and operation, with the requirements of Section 409A of the Code and the guidance thereunder. To the knowledge of the Company, no payment to be made under any 409A Plan is, or will be, subject to the penalties of Section 409A(a)(1) of the
Code. 
 2.3. Subsidiaries. The Company does not currently own or control, directly or indirectly, any interest in any other
corporation, partnership, trust, joint venture, limited liability company, association, or other business entity. The Company is not a participant in any joint venture, partnership or similar arrangement. 

  
 6 

 2.4. Authorization. All corporate action required to be taken by the Board and the
Company’s stockholders in order to authorize the Company to enter into the Transaction Agreements, and to issue the Shares at the Closing, the shares of Series D Preferred Stock issuable upon conversion of the Series D-1 Preferred Stock and the
Common Stock issuable upon conversion of the Shares and upon conversion of the shares of Series D Preferred Stock issuable upon conversion of the Series D-1 Preferred Stock, has been taken or will be taken prior to the Closing. All action on the
part of the officers of the Company necessary for the execution and delivery of the Transaction Agreements, the performance of all obligations of the Company under the Transaction Agreements to be performed as of the Closing, and the issuance and
delivery of the Shares has been taken or will be taken prior to the Closing. The Transaction Agreements, when executed and delivered by the Company, shall constitute valid and legally binding obligations of the Company, enforceable against the
Company in accordance with their respective terms except (i) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance, or other laws of general application relating to or affecting the enforcement of
creditors’ rights generally, (ii) as limited by laws relating to the availability of specific performance, injunctive relief, or other equitable remedies or (iii) to the extent the indemnification provisions contained in the
Investors’ Rights Agreement may be limited by applicable federal or state securities laws. 
 2.5. Valid Issuance of Shares.

 (a) The Shares, when issued, sold and delivered in accordance with the terms and for the consideration set forth in this Agreement, will
be validly issued, fully paid and nonassessable and free of restrictions on transfer other than restrictions on transfer under the Transaction Agreements, applicable state and federal securities laws and liens or encumbrances created by or imposed
by the Purchaser. Assuming the accuracy of the representations of the Purchaser in Section 3 of this Agreement and subject to the filings described in Subsection 2.6(ii) below, the Shares will be issued in compliance with all
applicable federal and state securities laws. The Common Stock issuable upon conversion of the Shares, the Series D Preferred Stock issuable upon conversion of the Series D-1 Preferred Stock and the Common Stock issuable upon conversion of the
Series D Preferred Stock issuable upon conversion of the Series D-1 Preferred Stock has been duly reserved for issuance, and upon issuance in accordance with the terms of the Restated Certificate, will be validly issued, fully paid and nonassessable
and free of restrictions on transfer other than restrictions on transfer under the Transaction Agreements, applicable federal and state securities laws and liens or encumbrances created by or imposed by the Purchaser. Based in part upon the
representations of the Purchaser in Section 3 of this Agreement, and subject to Subsection 2.6 below, the Common Stock issuable upon conversion of the Shares and upon conversion of the Series D Preferred Stock issuable upon
conversion of the Series D-1 Preferred Stock will be issued in compliance with all applicable federal and state securities laws. 

(b) No “bad actor” disqualifying event described in Rule 506(d)(1)(i)-(viii) under the Securities Act (a
“Disqualification Event”) is applicable to the Company or, to the Company’s knowledge, any Company Covered Person, except for a Disqualification Event as to which Rule 506(d)(2)(ii–iv) or (d)(3), is applicable. 

  
 7 

 2.6. Governmental Consents and Filings. Assuming the accuracy of the representations made
by the Purchaser in Section 3 of this Agreement, no consent, approval, order or authorization of, or registration, qualification, designation, declaration or filing with, any federal, state or local governmental authority is required on
the part of the Company in connection with the consummation of the transactions contemplated by this Agreement, except for (i) the filing of the Restated Certificate, which will have been filed as of the Closing, and (ii) filings pursuant
to Regulation D of the Securities Act, and applicable state securities laws, which have been made or will be made in a timely manner. 

2.7. Litigation. There is no claim, action, suit, proceeding, arbitration, complaint, charge or investigation pending or to the
Company’s knowledge, currently threatened (i) against the Company or any officer, director or Key Employee of the Company; (ii) to the Company’s knowledge, that questions the validity of the Transaction Agreements or the right of
the Company to enter into them, or to consummate the transactions contemplated by the Transaction Agreements; or (iii) to the Company’s knowledge, that would reasonably be expected to have, either individually or in the aggregate, a
Material Adverse Effect. Neither the Company nor, to the Company’s knowledge, any of its officers, directors or Key Employees is a party or is named as subject to the provisions of any order, writ, injunction, judgment or decree of any court or
government agency or instrumentality (in the case of officers, directors or Key Employees, such as would affect the Company). There is no action, suit, proceeding or investigation by the Company pending or which the Company intends to initiate. The
foregoing includes, without limitation, actions, suits, proceedings or investigations pending or threatened in writing (or any basis therefor known to the Company) involving the prior employment of any of the Company’s employees, their services
provided in connection with the Company’s business, or any information or techniques allegedly proprietary to any of their former employers, or their obligations under any agreements with prior employers. 

2.8. Intellectual Property. 

(a) Subsection 2.8(a) of the Disclosure Schedule lists (i) each patent, patent application, copyright registration or application
therefor, and trademark, service mark and domain name registration or application therefor of the Company and (ii) each Product Candidate of the Company. 

(b) Each current and former employee, consultant and officer of the Company has executed an agreement with the Company regarding the
assignment of inventions substantially in the form or forms delivered to the counsel for the Purchaser. No current or former Key Employee has excluded works or inventions from his or her assignment of inventions pursuant to any such agreement. 

(c) The Company (i) owns or has the right to use all Intellectual Property necessary (A) to develop, provide, manufacture, market
and sell the Product Candidates that the Company currently develops, manufactures, markets, sells or licenses and (B) to operate the Internal Systems and (ii) owns, has the right to use or reasonably believes it can acquire on commercially
reasonable terms all Intellectual Property necessary to develop, provide, manufacture, market and sell the Product Candidates that the Company currently plans to develop, manufacture, market, sell or license in the future. The Company has taken all

  
 8 

 
reasonable measures to protect the proprietary nature of each item of Company Intellectual Property, and to maintain in confidence all trade secrets and confidential information, that it owns or
uses. The patents and patent applications of the Company were prepared, filed and prosecuted in accordance with applicable laws and regulations, and have been duly maintained and are in full force and effect. No other person or entity has any rights
to any of the Company Intellectual Property owned by the Company (except pursuant to agreements or licenses specified in the Subsection 2.8(b) of the Disclosure Schedule), and, to the best of the Company’s knowledge, no other person or
entity is infringing, violating or misappropriating any of the Company Intellectual Property. To the Company’s knowledge, there are no pending or threatened legal or governmental proceedings relating to any Company Intellectual Property, other
than ex parte examination proceedings before the US Patent and Trademark Office or corresponding foreign patent offices. 
 (d) To the
Company’s knowledge, none of the Product Candidates currently under development by the Company, or the development, marketing, sale, provision or use thereof, infringes or violates, or constitutes a misappropriation of, any Intellectual
Property rights of any person or entity, and neither the marketing, sale, provision or use of any Product Candidates currently under development by the Company will, when such Product Candidates are commercially released by the Company, infringe or
violate, or constitute a misappropriation of, any Intellectual Property rights of any person or entity that exist as of the date of the Closing. None of the Internal Systems owned by the Company or, to the Company’s knowledge, licensed to the
Company, or the use thereof, infringes or violates, or constitutes a misappropriation of, any Intellectual Property rights of any person or entity. Subsection 2.8(c) of the Disclosure Schedule lists any complaint, claim or notice, or written
threat thereof, received by the Company alleging any such infringement, violation or misappropriation; and the Company has made available to the Purchaser complete and accurate copies of all written documentation in the possession of the Company
relating to any such complaint, claim, notice or threat. The Company has made available to the Purchaser complete and accurate copies of all written documentation in the Company’s possession relating to claims or disputes known to the Company
concerning any Company Intellectual Property. 
 (e) Subsection 2.8(e) of the Disclosure Schedule identifies each license or other
agreement pursuant to which the Company has licensed, distributed or otherwise granted any rights to any third party with respect to, any Company Intellectual Property. Except as described in Subsection 2.8(e) of the Disclosure Schedule, the
Company has not agreed to indemnify any person or entity against any infringement, violation or misappropriation of any Intellectual Property rights with respect to any Company Intellectual Property. 

(f) Subsection 2.8(f) of the Disclosure Schedule identifies each item of Company Intellectual Property that is owned by a party other
than the Company, and the license or agreement pursuant to which the Company uses it (excluding off-the-shelf software programs licensed by the Company pursuant to “shrink wrap” or “click through” licenses). 

(g) All of the copyrightable materials incorporated in, underlying or used with the Product Candidates have been created by employees of the
Company within the scope of their employment by the Company or by independent contractors of the Company who have executed agreements expressly assigning all right, title and interest in such copyrightable materials to the Company. No portion of
such copyrightable materials was jointly developed with any third party. 

  
 9 

 2.9. Compliance with Other Instruments. The Company is not in violation or default
(i) of any provisions of its Restated Certificate or Bylaws, (ii) of any instrument, judgment, order, writ or decree, (iii) under any note, indenture or mortgage, or (iv) under any lease, agreement, contract or purchase order to
which it is a party or by which it is bound that is required to be listed on the Disclosure Schedule, or, to its knowledge, of any provision of federal or state statute, rule or regulation applicable to the Company, the violation of which would have
a Material Adverse Effect. The execution, delivery and performance of the Transaction Agreements and the consummation of the transactions contemplated by the Transaction Agreements will not result in any such violation or be in conflict with or
constitute, with or without the passage of time and giving of notice, either (i) a default under any such provision, instrument, judgment, order, writ, decree, contract or agreement or (ii) an event which results in the creation of any
lien, charge or encumbrance upon any assets of the Company or the suspension, revocation, forfeiture, or nonrenewal of any material permit or license applicable to the Company. 

2.10. Agreements; Actions. 

(a) Except for the Transaction Agreements and except as set forth in Subsection 2.10 of the Disclosure Schedule, there are no
agreements, understandings, instruments, contracts or proposed transactions to which the Company is a party or by which it is bound that involve (i) obligations (contingent or otherwise) of, or payments to, the Company in excess of $100,000,
(ii) the license of any patent, copyright, trademark, trade secret or other proprietary right to or from the Company (excluding off-the-shelf software programs licensed by the Company pursuant to “shrink wrap” or “click
through” licenses), (iii) the grant of rights to manufacture, produce, assemble, license, market, or sell its products to any other Person that limit the Company’s exclusive right to develop, manufacture, assemble, distribute, market
or sell its products, or (iv) indemnification by the Company with respect to infringements of proprietary rights. 
 (b) The Company
has not (i) declared or paid any dividends, or authorized or made any distribution upon or with respect to any class or series of its capital stock, (ii) incurred any indebtedness for money borrowed or incurred any other liabilities
individually in excess of $200,000 or in excess of $500,000 in the aggregate, (iii) made any loans or advances to any Person, other than ordinary advances for travel expenses, or (iv) sold, exchanged or otherwise disposed of any of its
assets or rights, other than the sale of its inventory in the ordinary course of business. For the purposes of subsections (b) and (c) of this Subsection 2.10, all indebtedness, liabilities, agreements, understandings, instruments,
contracts and proposed transactions involving the same Person (including Persons the Company has reason to believe are affiliated with each other) shall be aggregated for the purpose of meeting the individual minimum dollar amounts of such
subsection. 
 (c) The Company is not a guarantor or indemnitor of any indebtedness of any other Person. 

  
 10 

 2.11. Certain Transactions. 

(a) Other than (i) standard employee benefits generally made available to all employees, (ii) standard director and officer
indemnification agreements approved by the Board and (iii) the purchase of shares of the Company’s capital stock and the issuance of options to purchase shares of the Company’s Common Stock, in each instance, approved in the written
minutes of the Board (previously made available to the Purchaser or its counsel), there are no agreements, understandings or proposed transactions between the Company and any of its officers, directors, consultants or Key Employees, or any Affiliate
thereof. 
 (b) The Company is not indebted, directly or indirectly, to any of its directors, officers or employees or to their respective
spouses or children or to any Affiliate of any of the foregoing, other than in connection with expenses or advances of expenses incurred in the ordinary course of business or employee relocation expenses and for other customary employee benefits
made generally available to all employees. None of the Company’s directors, officers or employees, or any members of their immediate families, or any Affiliate of the foregoing are, directly or indirectly, indebted to the Company or, to the
Company’s knowledge, have any (i) material commercial, industrial, banking, consulting, legal, accounting, charitable or familial relationship with any of the Company’s customers, suppliers, service providers, joint venture partners,
licensees and competitors, (ii) direct or indirect ownership interest in any firm or corporation with which the Company is affiliated or with which the Company has a business relationship, or any firm or corporation which competes with the
Company except that directors, officers or employees or stockholders of the Company may own stock in (but not exceeding two percent (2%) of the outstanding capital stock of) publicly traded companies that may compete with the Company or
(iii) financial interest in any material contract with the Company. 
 2.12. Rights of Registration and Voting Rights. Except as
provided in the Investors’ Rights Agreement, the Company is not under any obligation to register under the Securities Act any of its currently outstanding securities or any securities issuable upon exercise or conversion of its currently
outstanding securities. To the Company’s knowledge, except as contemplated in the Voting Agreement, no stockholder of the Company has entered into any agreements with respect to the voting of capital shares of the Company. 

2.13. Property. The property and assets that the Company owns are free and clear of all mortgages, deeds of trust, liens, loans and
encumbrances, except for statutory liens for the payment of current Taxes that are not yet delinquent and encumbrances and liens that arise in the ordinary course of business and do not materially impair the Company’s ownership or use of such
property or assets. With respect to the property and assets it leases, the Company is in compliance with such leases and, to its knowledge, holds a valid leasehold interest free of any liens, claims or encumbrances other than those of the lessors of
such property or assets. The Company does not own any real property. 
 2.14. Financial Statements. The Company has delivered to the
Purchaser its audited financial statements as of December 31, 2013 and unaudited financial statements as of September 30, 2014 (collectively, the “Financial Statements”). The Financial Statements have been prepared in accordance
with generally accepted accounting principles applied on a consistent basis throughout the periods indicated, except that they may not contain all footnotes 

  
 11 

 
required by generally accepted accounting principles. The Financial Statements fairly present in all material respects the financial condition and operating results of the Company as of the
dates, and for the periods, indicated therein, subject to normal year-end audit adjustments. Except as set forth in the Financial Statements, the Company has no material liabilities or obligations, contingent or otherwise, other than
(i) liabilities incurred in the ordinary course of business subsequent to September 30, 2014, (ii) obligations under contracts and commitments incurred in the ordinary course of business and (iii) liabilities and obligations of a
type or nature not required under generally accepted accounting principles to be reflected in the Financial Statements, which, in all such cases, individually and in the aggregate would not have a Material Adverse Effect. The Company maintains and
will continue to maintain a standard system of accounting established and administered in accordance with generally accepted accounting principles. 

2.15. Changes. Since September 30, 2014 there has not been: 

(a) any change in the assets, liabilities, financial condition or operating results of the Company from that reflected in the Financial
Statements, except changes in the ordinary course of business that have not caused, in the aggregate, a Material Adverse Effect; 
 (b) any
damage, destruction or loss, whether or not covered by insurance, that would have a Material Adverse Effect; 
 (c) any waiver or
compromise by the Company of a valuable right or of a material debt owed to it; 
 (d) any satisfaction or discharge of any lien, claim, or
encumbrance or payment of any obligation by the Company, except in the ordinary course of business and the satisfaction or discharge of which would not have a Material Adverse Effect; 

(e) any material change to a material contract or agreement by which the Company or any of its assets is bound or subject; 

(f) any material change in any compensation arrangement or agreement with any employee, officer, director or stockholder; 

(g) any resignation or termination of employment of any officer or Key Employee of the Company; 

(h) any mortgage, pledge, transfer of a security interest in, or lien, created by the Company, with respect to any of its material properties
or assets, except liens for Taxes not yet due or payable and liens that arise in the ordinary course of business and do not materially impair the Company’s ownership or use of such property or assets; 

(i) any loans or guarantees made by the Company to or for the benefit of its employees, officers or directors, or any members of their
immediate families, other than travel advances and other advances made in the ordinary course of its business; 

  
 12 

 (j) any declaration, setting aside or payment or other distribution in respect of any of the
Company’s capital stock, or any direct or indirect redemption, purchase, or other acquisition of any of such stock by the Company; 

(k) any sale, assignment or transfer of any Company Intellectual Property that could reasonably be expected to result in a Material Adverse
Effect; 
 (l) receipt of notice that there has been a loss of, or material order cancellation by, any major customer of the Company; 

(m) to the Company’s knowledge, any other event or condition of any character, other than events affecting the economy or the
Company’s industry generally, that could reasonably be expected to result in a Material Adverse Effect; or 
 (n) any arrangement or
commitment by the Company to do any of the things described in this Subsection 2.15. 
 2.16. Employee Matters. 

(a) As of the date hereof, the Company employs the number of full-time employees and the number of part-time employees and engages the number
of consultants or independent contractors set forth in Subsection 2.16 of the Disclosure Schedule. Subsection 2.16 of the Disclosure Schedule sets forth a detailed description of all compensation, including salary, bonus, severance
obligations and deferred compensation paid or payable for each officer, employee, consultant and independent contractor of the Company who received compensation in excess of $100,000 for the fiscal year ended December 31, 2013 or is anticipated
to receive compensation in excess of $100,000 for the fiscal year ending December 31, 2014. 
 (b) To the Company’s knowledge,
none of its employees is obligated under any contract (including licenses, covenants or commitments of any nature) or other agreement, or subject to any judgment, decree or order of any court or administrative agency, that would materially interfere
with such employee’s ability to promote the interest of the Company or that would conflict with the Company’s business. Neither the execution or delivery of the Transaction Agreements, nor the carrying on of the Company’s business by
the employees of the Company, nor the conduct of the Company’s business as now conducted and as presently proposed to be conducted, will, to the Company’s knowledge, conflict with or result in a breach of the terms, conditions, or
provisions of, or constitute a default under, any contract, covenant or instrument under which any such employee is now obligated. 
 (c)
The Company is not delinquent in payments to any of its employees, consultants, or independent contractors for any wages, salaries, commissions, bonuses, or other direct compensation for any service performed for it to the date hereof or amounts
required to be reimbursed to such employees, consultants, or independent contractors. The Company has complied in all material respects with all applicable state and federal equal employment opportunity laws and with other laws related to
employment, including those related to wages, hours, worker classification, and collective bargaining. The Company has withheld and paid to the appropriate governmental entity or is holding for payment not yet due to such governmental entity all
amounts required to be withheld from employees of the Company and is not liable for any arrears of wages, Taxes, penalties, or other sums for failure to comply with any of the foregoing. 

  
 13 

 (d) To the Company’s knowledge, no Key Employee intends to terminate employment with the
Company or is otherwise likely to become unavailable to continue as a Key Employee, nor does the Company have a present intention to terminate the employment of any of the foregoing. The employment of each employee of the Company is terminable at
the will of the Company. Except as set forth in Subsection 2.16 of the Disclosure Schedule or as required by law, upon termination of the employment of any such employees, no severance or other payments will become due. Except as set forth in
Subsection 2.16 of the Disclosure Schedule, the Company has no policy, practice, plan, or program of paying severance pay or any form of severance compensation in connection with the termination of employment services. 

(e) The Company has not made any representations regarding equity incentives to any officer, employees, director or consultant that are
inconsistent with the share amounts and terms set forth in the minutes of meetings of the Board. 
 (f) Each former Key Employee whose
employment was terminated by the Company has entered into an agreement with the Company providing for the full release of any claims against the Company or any related party arising out of such employment. 

(g) Subsection 2.16 of the Disclosure Schedule sets forth each employee benefit plan maintained, established or sponsored by the
Company, or which the Company participates in or contributes to, which is subject to the Employee Retirement Income Security Act of 1974, as amended (“ERISA”). The Company has made all required contributions and has no liability to
any such employee benefit plan, other than liability for health plan continuation coverage described in Part 6 of Title I(B) of ERISA, and has complied in all material respects with all applicable laws for any such employee benefit plan. 

(h) The Company is not bound by or subject to (and none of its assets or properties is bound by or subject to) any written or oral, express
or implied, contract, commitment or arrangement with any labor union, and no labor union has requested or, to the knowledge of the Company, has sought to represent any of the employees, representatives or agents of the Company. There is no strike or
other labor dispute involving the Company pending, or to the Company’s knowledge, threatened, which could have a Material Adverse Effect, nor is the Company aware of any labor organization activity involving its employees. 

(i) To the Company’s knowledge, none of its officers or other Key Employees has been (a) subject to voluntary or involuntary
petition under the federal bankruptcy laws or any state insolvency law or the appointment of a receiver, fiscal agent or similar officer by a court for his business or property; (b) convicted in a criminal proceeding or named as a subject of a
pending criminal proceeding (excluding traffic violations and other minor offenses); (c) subject to any order, judgment, or decree (not subsequently reversed, suspended, or vacated) of any court of competent jurisdiction permanently or
temporarily enjoining him from engaging, or otherwise imposing limits or conditions on his engagement in any securities, investment 

  
 14 

 
advisory, banking, insurance, or other type of business or acting as an officer or director of a public company; or (d) found by a court of competent jurisdiction in a civil action or by the
Securities and Exchange Commission or the Commodity Futures Trading Commission to have violated any federal or state securities, commodities, or unfair trade practices law, which such judgment or finding has not been subsequently reversed,
suspended, or vacated. 
 2.17. Tax Returns and Payments. There are no federal, state, county, local or foreign Taxes due and payable
by the Company which have not been timely paid. There are no accrued and unpaid federal, state, county, local or foreign Taxes of the Company which are due, whether or not assessed or disputed. There have been no examinations or audits of any Tax
Returns by any applicable federal, state, county, local or foreign governmental agency, nor, to the Company’s knowledge, threatened in writing. The Company has duly and timely filed all federal, state, county, local and foreign Tax Returns
required to have been filed by it, and all such Tax Returns were true, correct, and complete in all material respects. The Company has never received any notice of any Tax deficiency proposed or assessed against it, and there are in effect no
waivers of applicable statutes of limitations with respect to Taxes for any year. The Company does not have any liabilities for Taxes of any other person or entity by contract, as a transferee or successor, under U.S. Treasury Regulation section
1.1502-6 or analogous state, county, local or foreign provision or otherwise. 
 2.18. Insurance. The Company has in full force and
effect fire and casualty insurance policies with extended coverage, sufficient in amount (subject to reasonable deductions) to allow it to replace any of its properties that might be damaged or destroyed. 

2.19. Employee Agreements. Each current and former employee, consultant and officer of the Company has executed an agreement with the
Company regarding confidentiality and proprietary information substantially in the form or forms delivered to the counsel for the Purchaser (the “Confidential Information Agreements”). Each current and former Key Employee has executed a
non-competition and non-solicitation agreement substantially in the form or forms delivered to counsel for the Purchaser. The Company is not aware that any of its Key Employees is in violation of any agreement covered by this
Subsection 2.19. 
 2.20. Permits. The Company has all franchises, permits, licenses and any similar authority necessary
for the conduct of its business, the lack of which could reasonably be expected to have a Material Adverse Effect. The Company is not in default in any material respect under any of such franchises, permits, licenses or other similar authority. 

2.21. Clinical Trials. The studies, tests and preclinical and clinical trials, if any, conducted by or on behalf of the Company are
being conducted in all material respects in accordance with experimental protocols, procedures and controls pursuant to accepted professional and scientific standards for products or product candidates comparable to those being developed by the
Company and all applicable laws and regulations. The descriptions of, protocols for, and data and other results of, the studies, tests and trials conducted by or on behalf of the Company that have been furnished or made available to the Purchaser
are accurate and complete. The Company is not aware of any studies, tests or trials the results of which reasonably call into question the results of the studies, tests and trials conducted by or on behalf 

  
 15 

 
of the Company, and the Company has not received any notices or correspondence from the United States Food and Drug Administration (the “FDA”) or any foreign, state or local
agency or governmental body exercising comparable authority (each a “Governmental Entity”) or any Institutional Review Board or comparable authority requiring the termination, suspension or material modification of any studies,
tests or preclinical or clinical trials conducted by or on behalf of the Company. 
 2.22. FDA. The Company possesses all permits,
licenses, registrations, certificates, authorizations, orders and approvals from the appropriate federal, state or foreign regulatory authorities necessary to conduct its business, including all such permits, licenses, registrations, certificates,
authorizations, orders and approvals required by the FDA or any other federal, state or foreign agencies or bodies engaged in the regulation of pharmaceuticals or biohazardous materials. The Company has not received any notice of proceedings
relating to the suspension, modification, revocation or cancellation of any such permit, license, registration, certificate, authorization, order or approval. Neither the Company nor, to the Company’s knowledge, any officer, employee or agent
of the Company has been convicted of any crime or engaged in any conduct that has previously caused or would reasonably be expected to result in (A) disqualification or debarment by the FDA under 21 U.S.C. Sections 335(a) or (b), or any similar
law, rule or regulation of any other Governmental Entities, or (B) exclusion under 42 U.S.C. Section 1320a-7 or any similar law, rule or regulation of any Governmental Entities. 

2.23. Corporate Documents. The Restated Certificate and Bylaws of the Company are in the form made available to the Purchaser. The copy
of the minute books of the Company made available to the Purchaser contains minutes of all meetings of directors and stockholders and all actions by written consent without a meeting by the directors and stockholders since the date of incorporation
and accurately reflects in all material respects all actions by the directors (and any committee of directors) and stockholders with respect to all transactions referred to in such minutes. 

2.24. Environmental and Safety Laws. Except as could not reasonably be expected to have a Material Adverse Effect, to the best of its
knowledge: (a) the Company is and has been in compliance with all Environmental Laws; (b) there has been no release or to the Company’s knowledge threatened release of any pollutant, contaminant or toxic or hazardous material,
substance or waste, or petroleum or any fraction thereof, (each a “Hazardous Substance”) on, upon, into or from any site currently or heretofore owned, leased or otherwise used by the Company; (c) there have been no Hazardous
Substances generated by the Company that have been disposed of or come to rest at any site that has been included in any published U.S. federal, state or local “superfund” site list or any other similar list of hazardous or toxic waste
sites published by any governmental authority in the United States; and (d) there are no underground storage tanks located on, no polychlorinated biphenyls (“PCBs”) or PCB-containing equipment used or stored on, and no
hazardous waste as defined by the Resource Conservation and Recovery Act, as amended, stored on, any site owned or operated by the Company, except for the storage of hazardous waste in compliance with Environmental Laws. The Company has made
available to the Purchaser true and complete copies of all material environmental records, reports, notifications, certificates of need, permits, pending permit applications, correspondence, engineering studies, and environmental studies or
assessments. 

  
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 For purposes of this Subsection 2.24, “Environmental Laws” means any law,
regulation, or other applicable requirement relating to (a) releases or threatened release of Hazardous Substance; (b) pollution or protection of employee health or safety, public health or the environment; or (c) the manufacture,
handling, transport, use, treatment, storage, or disposal of Hazardous Substances. 
 2.25. Qualified Small Business Stock. As of and
immediately following the Closing: (i) the Company will be an eligible corporation as defined in Section 1202(e)(4) of the Code, (ii) the Company will not have made purchases of its own stock described in Code
Section 1202(c)(3)(B) during the one-year period preceding the Closing, except for purchases that are disregarded for such purposes under Treasury Regulation Section 1.1202-2 and (iii) the Company’s aggregate gross assets, as
defined by Code Section 1202(d)(2), at no time between its incorporation and through the Closing have exceeded $50 million, taking into account the assets of any corporations required to be aggregated with the Company in accordance with Code
Section 1202(d)(3); provided, however, that in no event shall the Company be liable to the Purchaser or any other party for any damages arising from any subsequently proven or identified error in the Company’s determination
with respect to the applicability or interpretation of Code Section 1202, unless such determination shall have been given by the Company in a manner either grossly negligent or fraudulent. 

2.26. Shell Company Status. The Company is not, nor has it ever been, an issuer identified in Rule 144(i)(1) promulgated under the
Securities Act. 
 2.27. Investment Company. The Company is not an investment company within the meaning of the Investment Company
Act of 1940, as amended. 
 2.28. Disclosure. The Company has made available to the Purchaser all the information reasonably
available to the Company that the Purchaser has requested for deciding whether to acquire the Shares. No representation or warranty of the Company contained in this Agreement, as qualified by the Disclosure Schedule, and no certificate furnished or
to be furnished to the Purchaser at the Closing contains any untrue statement of a material fact or, to the Company’s knowledge, omits to state a material fact necessary in order to make the statements contained herein or therein not misleading
in light of the circumstances under which they were made. It is understood that this representation is qualified by the fact that the Company has not delivered to the Purchaser, and has not been requested to deliver, a private placement or similar
memorandum or any written disclosure of the types of information customarily furnished to purchasers of securities. 
 3. Representations
and Warranties of the Purchaser. The Purchaser hereby represents and warrants to the Company that: 
 3.1. Authorization. The
Purchaser has full power and authority to enter into the Transaction Agreements. The Transaction Agreements to which the Purchaser is a party, when executed and delivered by the Purchaser, will constitute valid and legally binding obligations of the
Purchaser, enforceable in accordance with their terms, except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium, fraudulent conveyance, and any other laws of general application affecting enforcement of
creditors’ rights generally, and as limited by laws relating to the availability of specific performance, injunctive relief, or other equitable remedies, or (b) to the extent the indemnification provisions contained in the Investors’
Rights Agreement may be limited by applicable federal or state securities laws. 

  
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 3.2. Purchase Entirely for Own Account. This Agreement is made with the Purchaser in
reliance upon the Purchaser’s representation to the Company, which by the Purchaser’s execution of this Agreement, the Purchaser hereby confirms, that the Shares to be acquired by the Purchaser will be acquired for investment for the
Purchaser’s own account, not as a nominee or agent, and not with a view to the resale or distribution of any part thereof, and that the Purchaser has no present intention of selling, granting any participation in, or otherwise distributing the
same. By executing this Agreement, the Purchaser further represents that the Purchaser does not presently have any contract, undertaking, agreement or arrangement with any Person to sell, transfer or grant participations to such Person or to any
third Person, with respect to any of the Shares. The Purchaser has not been formed for the specific purpose of acquiring the Shares. 
 3.3.
Disclosure of Information. The Purchaser has had an opportunity to discuss the Company’s business, management, financial affairs and the terms and conditions of the offering of the Shares with the Company’s management and has had an
opportunity to review the Company’s facilities. The foregoing, however, does not limit or modify the representations and warranties of the Company in Section 2 of this Agreement or the right of the Purchaser to rely thereon. 

3.4. Restricted Securities. The Purchaser understands that the Shares have not been, and will not be, registered under the Securities
Act, by reason of a specific exemption from the registration provisions of the Securities Act which depends upon, among other things, the bona fide nature of the investment intent and the accuracy of the Purchaser’s representations as expressed
herein. The Purchaser understands that the Shares are “restricted securities” under applicable U.S. federal and state securities laws and that, pursuant to these laws, the Purchaser must hold the Shares indefinitely unless they are
registered with the Securities and Exchange Commission and qualified by state authorities, or an exemption from such registration and qualification requirements is available. The Purchaser acknowledges that the Company has no obligation to register
or qualify the Shares, the Series D Preferred Stock into which the Series D-1 Preferred stock may be converted or the Common Stock into which such Shares or Series D Preferred Stock may be converted, for resale except as set forth in the
Investors’ Rights Agreement. The Purchaser further acknowledges that if an exemption from registration or qualification is available, it may be conditioned on various requirements including, but not limited to, the time and manner of sale, the
holding period for the Shares, and on requirements relating to the Company which are outside of the Purchaser’s control, and which the Company is under no obligation and may not be able to satisfy. 

3.5. No Public Market. The Purchaser understands that no public market now exists for the Shares, and that the Company has made no
assurances that a public market will ever exist for the Shares. 

  
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 3.6. Legends. The Purchaser understands that the Shares and any securities issued in
respect of or exchange for the Shares, may bear one or all of the following legends: 
 (a) “THE SHARES REPRESENTED BY THIS CERTIFICATE
HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AND HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE SALE OR DISTRIBUTION THEREOF. NO SUCH TRANSFER MAY BE EFFECTED WITHOUT AN EFFECTIVE REGISTRATION
STATEMENT RELATED THERETO OR AN OPINION OF COUNSEL IN A FORM SATISFACTORY TO THE COMPANY THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE SECURITIES ACT OF 1933.” 

(b) Any legend set forth in, or required by, the other Transaction Agreements. 

(c) Any legend required by the securities laws of any state to the extent such laws are applicable to the Shares represented by the
certificate so legended. 
 3.7. Accredited Investor. The Purchaser is an accredited investor as defined in Rule 501(a) of Regulation
D promulgated under the Securities Act 
 3.8. Foreign Investors. If the Purchaser is not a United States person (as defined by
Section 7701(a)(30) of the Code), the Purchaser hereby represents that it has satisfied itself as to the full observance of the laws of its jurisdiction in connection with any invitation to subscribe for the Shares or any use of this Agreement,
including (i) the legal requirements within its jurisdiction for the purchase of the Shares that are applicable to the Purchaser, (ii) any foreign exchange restrictions applicable with respect to such purchase by the Purchaser,
(iii) any governmental or other consents that may need to be obtained by the Purchaser, and (iv) the income tax and other tax consequences, if any, that may be relevant to the Purchaser in connection the purchase, holding, redemption,
sale, or transfer of the Shares. The Purchaser’s subscription and payment for and continued beneficial ownership of the Shares will not violate any applicable securities or other laws of the Purchaser’s jurisdiction applicable to it. For
the avoidance of doubt, the Purchaser is not making any representations or warranties as to the actions taken or required to be taken by the Company in connection herewith. 

3.9. No General Solicitation. Neither the Purchaser, nor any of its officers, directors, employees, agents, stockholders or partners
has either directly or indirectly, including through a broker or finder (a) engaged in any general solicitation, or (b) published any advertisement in connection with the offer and sale of the Shares. 

3.10. Exculpation. The Purchaser acknowledges that it is not relying upon any Person, other than the Company and its officers and
directors, in making its investment or decision to invest in the Company. 
 3.11. Residence. If the Purchaser is an individual, then
the Purchaser resides in the state or province identified in the address of the Purchaser set forth on its signature page hereto; if the Purchaser is a partnership, corporation, limited liability company or other entity, then the office or offices
of the Purchaser in which its principal place of business is identified is the address or addresses of the Purchaser set forth on its signature page hereto. 

  
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 3.12. Bad Actor Matters. If the Purchaser is (or, as a result of the exercise of its
purchase of Shares hereunder, will become) a beneficial owner of 20% or more of the Company’s outstanding voting securities, calculated on the basis of voting power, or otherwise a Person described in the first paragraph of Rule 506(d)(1)
promulgated under the Securities Act, neither (i) the Purchaser, (ii) any of its directors, officers (as defined under Rule 16a-1 promulgated under the Exchange Act), other officers that may serve as a director or officer of the Company,
general partners or managing members, nor (iii) any beneficial owner of the Purchaser which is a 20% beneficial owner of the voting securities of the Company (in accordance with Rule 506(d) promulgated under the Securities Act) is subject
to any Disqualification Event (as defined in Section 2.5). 
 4. Conditions to the Purchaser’s Obligations at the
Closing. The obligations of the Purchaser to purchase Shares at the Closing are subject to the fulfillment, on or before the Closing, of each of the following conditions, unless otherwise waived: 

4.1. Representations and Warranties. The representations and warranties of the Company contained in Section 2 shall be true
and correct in all respects as of the Closing. 
 4.2. Performance. The Company shall have performed and complied with all covenants,
agreements, obligations and conditions contained in this Agreement that are required to be performed or complied with by the Company on or before the Closing. 

4.3. Compliance Certificate. If the date of the Closing is after the date of this Agreement, the President of the Company shall deliver
to the Purchaser at the Closing a certificate certifying that the conditions specified in Subsections 4.1 and 4.2 have been fulfilled. 

4.4. Qualifications. All authorizations, approvals or permits, if any, of any governmental authority or regulatory body of the United
States or of any state that are required in connection with the lawful issuance and sale of the Shares pursuant to this Agreement shall be obtained and effective as of the Closing. 

4.5. Opinion of Counsel. The Purchaser shall have received from counsel for the Company an opinion, dated as of the Closing, in form
and substance satisfactory to the Purchaser. 
 4.6. Board of Directors. As of the Closing, the authorized size of the Board shall be
eight (8) directors, and the Board shall be comprised of Noubar B. Afeyan, Greg Behar, David A. Berry, Werner Cautreels, Peter Barton Hutt, Richard N. Kender, Lorence H. Kim and Roger J. Pomerantz. 

4.7. Investors’ Rights Agreement. The Company shall have executed and delivered the Investors’ Rights Agreement. 

4.8. Voting Agreement. The Company shall have executed and delivered the Voting Agreement. 

  
 20 

 4.9. Restated Certificate. The Company shall have filed the Restated Certificate with the
Secretary of State of Delaware on or prior to the Closing, which shall continue to be in full force and effect as of the Closing. 
 4.10.
Secretary’s Certificate. The Secretary or Assistant Secretary of the Company shall have delivered to the Purchaser at the Closing a certificate certifying (i) the Bylaws of the Company, (ii) resolutions of the Board approving
the Transaction Agreements and the transactions contemplated under the Transaction Agreements and (iii) resolutions of the stockholders of the Company approving the Restated Certificate. 

4.11. Proceedings and Documents. All corporate and other proceedings in connection with the transactions contemplated at the Closing
and all documents incident thereto shall be reasonably satisfactory in form and substance to the Purchaser, and the Purchaser (or its counsel) shall have received all such counterpart original and certified or other copies of such documents as
reasonably requested. Such documents may include good standing certificates. 
 5. Conditions of the Company’s Obligations at the
Closing. The obligations of the Company to sell Shares to the Purchaser at the Closing are subject to the fulfillment, on or before the Closing, of each of the following conditions, unless otherwise waived: 

5.1. Representations and Warranties. The representations and warranties of the Purchaser contained in Section 3 shall be
true and correct in all respects as of the Closing. 
 5.2. Performance. The Purchaser shall have performed and complied with all
covenants, agreements, obligations and conditions contained in this Agreement that are required to be performed or complied with by it on or before the Closing. 

5.3. Qualifications. All authorizations, approvals or permits, if any, of any governmental authority or regulatory body of the United
States or of any state that are required in connection with the lawful issuance and sale of the Shares pursuant to this Agreement shall be obtained and effective as of the Closing. 

5.4. Investors’ Rights Agreement. The Purchaser shall have executed and delivered the Investors’ Rights Agreement. 

5.5. Voting Agreement. The Purchaser shall have executed and delivered the Voting Agreement. 

6. Right of First Refusal. 

6.1. Grant. Subject to the terms of Subsections 6.6, 6.7 and 6.10 below, the Purchaser hereby unconditionally and
irrevocably grants to the Company a Right of First Refusal to purchase all of the Transfer Stock that the Purchaser may propose to transfer in a Proposed Purchaser Transfer, at the same price and on the same terms and conditions, subject to
Subsection 6.3, as those offered to the Prospective Transferee. 

  
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 6.2. Notice. If the Purchaser proposes to make a Proposed Purchaser Transfer, the
Purchaser must deliver a Proposed Transfer Notice to the Company prior to the consummation of such Proposed Purchaser Transfer. To exercise its Right of First Refusal under this Section 6, the Company must deliver a Company Notice to the
Purchaser within fifteen (15) days after delivery of the Proposed Transfer Notice (the “Consideration Period”). In the event that, prior to the expiration of the Consideration Period, the Company waives in writing in accordance
with Subsection 9.8 hereof its right to exercise its Right of First Refusal under this Section 6 or does not deliver a Company Notice to the Purchaser, then the Purchaser shall be entitled to consummate such Proposed Purchaser
Transfer. For the avoidance of doubt, the Purchaser shall not consummate the purchase and sale of Transfer Stock with any third party in connection with any Proposed Purchaser Transfer prior to or during the Consideration Period (unless, for the
avoidance of doubt, the Company waives in writing in accordance with Subsection 9.8 hereof its right to exercise its Right of First Refusal under this Section 6 during the Consideration Period). 

6.3. Consideration; Closing. If the consideration proposed to be paid for the Transfer Stock is in property, services or other non-cash
consideration, the fair market value of the consideration shall be as determined in good faith by the Board and as set forth in the Company Notice; provided, however, that if the Purchaser disagrees with such determination by the
Board, the Purchaser shall have the right, at its sole cost and expense, to have the fair market value of such consideration determined by an independent appraiser of national reputation that is reasonably acceptable to the Board, in which case the
fair market value thereof shall be the higher of the amount determined by the Board or such independent appraiser. If the Company cannot for any reason pay for the Transfer Stock in the same form of non-cash consideration, the Company may pay the
cash value equivalent thereof, as determined in accordance with the immediately preceding sentence. The closing of the purchase of Transfer Stock by the Company shall take place, and all payments from the Company shall have been delivered to the
Purchaser, by the later of (i) the date specified in the Proposed Transfer Notice as the intended closing date of the Proposed Purchaser Transfer and (ii) thirty (30) days after the expiration of the Consideration Period. 

6.4. Transfer Void; Equitable Relief. Any Proposed Purchaser Transfer not made in compliance with the requirements of this
Section 6 shall be null and void ab initio, shall not be recorded on the books of the Company or its transfer agent and shall not be recognized by the Company. The Purchaser acknowledges and agrees that any breach of this
Section 6 would result in substantial harm to the Company for which monetary damages alone could not adequately compensate. Therefore, the Purchaser unconditionally and irrevocably agrees that the Company shall be entitled to seek
protective orders, injunctive relief and other remedies available at law or in equity (including, without limitation, seeking specific performance or the rescission of purchases, sales and other transfers of Transfer Stock not made in strict
compliance with this Section 6). 
 6.5. Violation of First Refusal Right. If the Purchaser becomes obligated to sell any
Transfer Stock to the Company under this Section 6 and fails to deliver such Transfer Stock in accordance with the terms of this Section 6, the Company may, at its option, in addition to all other remedies it may have, send
to the Purchaser the purchase price for such Transfer Stock as is herein specified and transfer to the name of the Company on the Company’s books the certificate or certificates representing the Transfer Stock to be sold. 

  
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 6.6. Exempted Transfers. Notwithstanding the foregoing or anything to the contrary herein,
the provisions of this Section 6 shall not apply upon a transfer by the Purchaser to any of its Affiliates; provided that such shares of Transfer Stock shall at all times remain subject to the terms and restrictions set forth in
this Agreement and such transferee shall, as a condition to such issuance, deliver a counterpart signature page to this Agreement as confirmation that such transferee shall be bound by all the terms and conditions of this Agreement as a Purchaser
(but only with respect to the securities so transferred to the transferee), including the obligations of the Purchaser with respect to Proposed Purchaser Transfers of such Transfer Stock pursuant to this Section 6. For the avoidance of
doubt, the Purchaser shall not transfer any shares of Transfer Stock to an Affiliate for the purposes of circumventing the Company’s rights under this Section 6. 

6.7. Deemed Liquidation Event. Notwithstanding the foregoing or anything to the contrary herein, the provisions of this
Section 6 shall not apply to the sale of any Transfer Stock pursuant to a Deemed Liquidation Event (as defined in the Restated Certificate) that has been approved by the Board. 

6.8. Prohibited Transferees. Notwithstanding the foregoing, the Purchaser shall not assign, sell, offer to sell, pledge, mortgage,
hypothecate, dispose of or otherwise transfer or encumber any Transfer Stock (or any interest therein) to any entity which, in the determination of the Board, is directly or indirectly engaged in the research, development and/or commercialization of
microbiome therapeutics. 
 6.9. Legend. Each certificate representing shares of Transfer Stock held by the Purchaser or issued to
any permitted transferee in connection with a transfer permitted by Subsection 6.6 hereof shall be endorsed with the following legend: 

THE SALE, PLEDGE, HYPOTHECATION OR TRANSFER OF THE SECURITIES REPRESENTED BY THIS CERTIFICATE IS SUBJECT TO, AND IN CERTAIN CASES PROHIBITED
BY, THE TERMS AND CONDITIONS OF A RIGHT OF FIRST REFUSAL SET FORTH IN A CERTAIN SERIES D PREFERRED STOCK PURCHASE AGREEMENT BY AND BETWEEN THE STOCKHOLDER AND THE CORPORATION. COPIES OF SUCH AGREEMENT MAY BE OBTAINED UPON WRITTEN REQUEST TO THE
SECRETARY OF THE CORPORATION. 
 The Purchaser agrees that the Company may instruct its transfer agent to impose transfer restrictions on the shares
represented by certificates bearing the legend referred to in this Subsection 6.9 above to enforce the provisions of this Agreement, and the Company agrees to promptly do so. The Company shall remove such legend upon the termination of this
Section 6 at the request of the holder by causing replacement certificate or certificates to be issued to such holder that do not contain such legend. 

  
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 6.10. Termination of Rights. The covenants set forth in Section 6 shall
terminate and be of no further force or effect (i) upon the consummation of the IPO or (ii) on the third anniversary of the Closing Date, whichever occurs first. 

7. HSR Filing. The Company and the Purchaser shall cooperate with each other and use their commercially reasonable efforts to make, as
soon as reasonably practical after the date hereof but no later than December 29, 2014, all necessary filings and submissions that may be required under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended (the “HSR
Act”) to cause a Series D-1 Triggering Event (as defined in the Restated Certificate) to occur with respect to the shares of Series D-1 Preferred Stock owned by the Purchaser. Each of the parties hereto agrees to use its commercially
reasonable efforts to furnish or cause to be furnished, as promptly as practicable, all information and documents requested with respect to the HSR Act and shall otherwise cooperate with the applicable governmental body in order to comply with the
HSR Act and cause a Series D-1 Triggering Event to occur in as expeditious a manner as possible. Each of the parties hereto shall consult, and share drafts of any filings or communications, a reasonable period of time in advance with respect to and
consider in good faith the comments and views of the other party in connection with any filing, communication, defense, litigation, negotiation or strategy and any final decisions with respect thereto in each case relating to the HSR Act or any
antitrust or unfair competition law regarding any of the transactions contemplated hereby, to the extent reasonably practicable and to the extent permitted by applicable law, and shall give the other party and its Representatives a reasonable
advance opportunity to attend and participate in any in-person or telephonic meeting or conference with any governmental authority or, in connection with any litigation by a private party, relating to the HSR Act or any antitrust or unfair
competition law regarding any of the transactions contemplated hereby, and shall provide concurrent copies to the other party of any material written communications or filings with respect thereto. Each of the parties hereto shall use commercially
reasonable efforts to resolve such objections, if any, as any governmental body may assert with respect to this Agreement and the transactions contemplated hereby (including, without limitation, with respect to the Purchaser’s acquisition of
additional voting securities of the Company) in connection with the HSR Act or any antitrust or unfair competition law in order to cause a Series D-1 Triggering Event to occur with respect to the shares of Series D-1 Preferred Stock held by the
Purchaser. In the event that a suit is instituted by a person or governmental body challenging this Agreement and the transactions contemplated hereby as violative of the HSR Act or any antitrust or unfair competition law, each of the parties shall
use commercially reasonable efforts to resist or resolve such suit. Each party shall, upon request by any other party, furnish the other parties with all information concerning itself, its subsidiaries, directors, officers and stockholders and such
other matters as may reasonably be necessary or advisable in connection with any statement, filing, ruling request, notice or application made by or on behalf of the parties or any of their respective subsidiaries to any third party and/or any
governmental body with respect to the HSR Act or any antitrust or unfair competition law. Notwithstanding anything in this Section 7 or this Agreement to the contrary, nothing in this Section 7 or this Agreement shall
require, or be deemed to require, the Company or the Purchaser (a) to propose, negotiate, offer to, commit to or effect any sale, divestiture, or disposition of assets or businesses, or licenses or (b) to agree to hold separate any assets
or agree to any similar arrangements or to commit to restrict the dominion or control of its business or to conduct its business in a specified manner. 

  
 24 

 8. Standstill. 

8.1. Until the earlier of (i) the fifth anniversary of the Closing Date or (ii) the third anniversary of the consummation of the
IPO, unless approved in advance in writing by the Board, the Purchaser agrees that neither the Purchaser nor any of its Affiliates or Representatives acting on behalf of or in concert with the Purchaser (or any of its Affiliates or Representatives)
will in any manner, directly or indirectly: 
 (a) effect or seek, offer or propose (whether publicly or otherwise) to effect, or cause or
participate in or in any way advise, assist or encourage any other person to effect or seek, offer or propose (whether publicly or otherwise) to effect or participate in, (i) any acquisition of any of the Company’s convertible debt
securities, equity securities or assets, or rights or options to acquire interests in or beneficially own any of the Company’s convertible debt securities, equity securities or assets, other than from the underwriters in connection with the
IPO, (ii) any business combination, merger, tender offer, exchange offer or similar transaction involving the Company or any of its subsidiaries, (iii) any restructuring, recapitalization, liquidation, dissolution or similar transaction
involving the Company or any of its subsidiaries, (iv) make any statement or proposal to the board of directors of any of the Company, any of the Company’s Affiliates or Representatives or any of the Company’s stockholders regarding,
or make any public announcement, proposal or offer (including “proxies” as such terms are used in the rules of the Securities and Exchange Commission) with respect to, or otherwise solicit, seek or offer to effect (including, for the
avoidance of doubt, indirectly by means of communication with the press or media) any proposal to seek representation on the Board or otherwise seek to control or influence the management, the Board or policies of any of the Company, or (v) any
proposal, arrangement or other statement that is inconsistent with the terms of this Agreement, including, without limitation, this Subsection 8.1(a); 

(b) instigate, encourage or assist any third party (including, without limitation, forming a “group”, as defined under applicable
federal and state securities laws, with any such third party) to do, or enter into any discussions or agreements with any third party with respect to, any of the securities of the Company or the actions set forth in Subsection 8.1(a) above;

 (c) otherwise act, alone or in concert with others, to seek control or influence the management, the Board or the policies of the
Company; 
 (d) take any action which would reasonably be expected to require the Company or any of its Affiliates to make a public
announcement regarding any of the types of actions or matters set forth in Subsection 8.1(a) above; or 
 (e) have any discussions
or enter into any arrangements, understandings or agreements (whether written or oral) with, or advise, assist or encourage, any other persons in connection with any of the foregoing. 

  
 25 

 Subject to the last sentence of Subsection 8.2, the Purchaser also agrees not to request that the Company,
directly or indirectly, terminate or amend or waive any provision of this Section 8 (including, without limitation, this sentence). 

8.2. The restrictions set forth in Subsection 8.1 shall terminate and be of no further force and effect upon (i) the Company
publicly announcing that it has entered into, may enter into or shall enter into, a definitive agreement for a transaction involving the purchase of a majority of the voting power of the Company’s equity securities or all or substantially all
of the Company’s assets (whether by merger, consolidation, business combination, tender or exchange offer, recapitalization, restructuring, sale, equity issuance or otherwise) or (ii) the Company publicly announcing the submission of a
bona fide offer or public attempt by a third party to enter into a transaction involving the purchase of a majority of the voting power of the Company’s equity securities or all or substantially all of the Company’s assets (whether by
merger, consolidation, business combination, tender or exchange offer, recapitalization, restructuring, sale, equity issuance or otherwise); provided, however, that occurrence of any of the events set forth above in clauses
(i) and (ii) of this Subsection 8.2 shall not cause the restrictions set forth Subsection 8.1 to terminate unless, and until such time as, none of the directors, officers or employees of the Purchaser or any of its Affiliates
is a member of the Board. The restrictions set forth in Subsection 8.1(a) shall not prevent the Purchaser from making a proposal regarding a possible transaction described in Subsection 8.1(a) directly to the Board on a confidential
basis if such proposal does not require the Company to make a public announcement regarding this Agreement, a possible transaction or any of the matters described in Subsection 8.1. The restrictions set forth in Subsection 8.1 shall
not apply to or preclude any licensing arrangement or an asset transfer of a similar nature between the Company or any of its Affiliates, on the one hand, and the Purchaser or any of its Affiliates, on the other hand; provided,
however, that (a) if the Purchaser or any of its Affiliates makes a proposal to the Company or any of its Affiliates with respect to any such arrangement or transfer, (i) as a condition hereto, the Purchaser or its applicable
Affiliate shall deliver written notice to the Company that such proposal is being made pursuant to this sentence and is therefore not subject to the restrictions set forth in Subsection 8.1 and (ii) such proposal shall be made on a
confidential basis; (b) neither the Purchaser nor any of its Affiliates shall use the exceptions set forth in this sentence for the purposes of circumventing the restrictions set forth in Subsection 8.1; and (c) any such arrangement
or transfer shall be negotiated by the parties thereto on a confidential basis. 
 8.3. No failure or delay by the Company in exercising any
right, power or privilege hereunder shall operate as a waiver thereof, nor shall any single or partial exercise thereof preclude any other or further exercise thereof or the exercise of any other right, power or privilege hereunder. 

8.4. For purposes of this Section 8, the term “Representative” shall not include, or be deemed to include for any
purpose, any director, officer or employee of the Purchaser or any of its Affiliates who is a member of the Board (including any individual designated by the Purchaser to serve on the Board pursuant to Subsection 1.2(c) of the Voting Agreement) when
such person is acting in his or her capacity as a member of the Board and not on behalf of the Purchaser or any of its Affiliates. 

  
 26 

 9. Miscellaneous. 

9.1. Survival of Warranties and Covenants. Unless otherwise set forth in this Agreement, the representations, warranties and covenants
of the Company and the Purchaser contained in or made pursuant to this Agreement shall survive the execution and delivery of this Agreement and the Closing and shall in no way be affected by any investigation or knowledge of the subject matter
thereof made by or on behalf of the Purchaser or the Company. 
 9.2. Successors and Assigns. This Agreement, and the rights and
obligations of the Purchaser hereunder, may be assigned by the Purchaser to (a) any person or entity to which Shares, the shares of Series D Preferred Stock issued upon conversion of the Series D-1 Preferred Stock or the Common Stock issued
upon exercise of the Shares or the shares of Series D Preferred Stock issued upon conversion of the Series D-1 Preferred Stock are transferred by the Purchaser, or (b) to any to any Affiliate, partner, member, stockholder or subsidiary of the
Purchaser, and, in each case, such transferee shall be deemed a “Purchaser” for purposes of this Agreement; provided that each such assignment of rights shall be contingent upon the transferee providing a written instrument to the Company
notifying the Company of such transfer and assignment and agreeing in writing to be bound by the terms of this Agreement. The Purchaser shall cause any proposed purchaser, pledgee or transferee of Shares, the shares of Series D Preferred Stock
issued upon conversion of the Series D-1 Preferred Stock or the Common Stock issued upon exercise of the Shares or the shares of Series D Preferred Stock issued upon conversion of the Series D-1 Preferred Stock to agree to take and hold such
securities subject to the provisions and upon the conditions specified in this Agreement. The Company may not assign its rights under this Agreement. 

9.3. Governing Law. This Agreement and any controversy arising out of or relating to this Agreement shall be governed by and construed
in accordance with the internal laws of the Commonwealth of Massachusetts, without regard to conflict of law principles that would result in the application of any law other than the law of the Commonwealth of Massachusetts. 

9.4. Counterparts. This Agreement may be executed in two or more counterparts, each of which shall be deemed an original, but all of
which together shall constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (including pdf) or other transmission method and any counterpart so delivered shall be deemed to have been duly and validly
delivered and be valid and effective for all purposes. 
 9.5. Titles and Subtitles. The titles and subtitles used in this Agreement
are used for convenience only and are not to be considered in construing or interpreting this Agreement. 
 9.6. Notices. All notices
and other communications given or made pursuant to this Agreement shall be in writing and shall be deemed effectively given upon the earlier of actual receipt or: (a) personal delivery to the party to be notified, (b) when sent, if sent by
facsimile during normal business hours of the recipient, and if not sent during normal business hours, then on the recipient’s next business day, (c) five (5) days after having been sent by registered or certified mail, return receipt
requested, postage prepaid, or (d) one (1) business day 

  
 27 

 
after deposit with a nationally recognized overnight courier, freight prepaid, specifying next business day delivery, with written verification of receipt. All communications shall be sent to the
respective parties at their address as set forth on the signature pages hereto, or to such facsimile number or address as subsequently modified by written notice given in accordance with this Subsection 9.6. If notice is given to the Company,
a copy shall also be given to Latham & Watkins LLP, John Hancock Tower, 27th Floor, 200 Clarendon Street, Boston, MA 02116, Attention Peter N. Handrinos, Facsimile Number:
(617) 948-6060, and if notice is given to the Purchaser, a copy shall also be given to Mayer Brown LLP, 1675 Broadway, New York, NY 10019, Attention: David A. Carpenter, Facsimile Number: (212) 849-5795. 

9.7. No Finder’s Fees. Each party represents that it neither is nor will be obligated for any finder’s fee or commission in
connection with this transaction. The Purchaser agrees to indemnify and to hold harmless the Company from any liability for any commission or compensation in the nature of a finder’s or broker’s fee arising out of this transaction (and the
costs and expenses of defending against such liability or asserted liability) for which the Purchaser or any of its officers, employees, or representatives is responsible. The Company agrees to indemnify and hold harmless the Purchaser from any
liability for any commission or compensation in the nature of a finder’s or broker’s fee arising out of this transaction (and the costs and expenses of defending against such liability or asserted liability) for which the Company or any of
its officers, employees or representatives is responsible. 
 9.8. Amendments and Waivers. Any term of this Agreement may be amended,
terminated or waived only with the written consent of the Company and the Purchaser. Any amendment or waiver effected in accordance with this Subsection 9.8 shall be binding upon the Purchaser and each transferee of the Shares (or the Common
Stock issuable upon conversion thereof, the Series D Preferred Stock issuable upon conversion thereof or the Common Stock issuable upon conversion of the Series D Preferred Stock issuable upon conversion of the Series D-1 Preferred Stock), each
future holder of all such securities, and the Company. 
 9.9. Severability. The invalidity or unenforceability of any provision
hereof shall in no way affect the validity or enforceability of any other provision. 
 9.10. Delays or Omissions. No delay or
omission to exercise any right, power or remedy accruing to any party under this Agreement, upon any breach or default of any other party under this Agreement, shall impair any such right, power or remedy of such non-breaching or non-defaulting
party nor shall it be construed to be a waiver of any such breach or default, or an acquiescence therein, or of or in any similar breach or default thereafter occurring; nor shall any waiver of any single breach or default be deemed a waiver of any
other breach or default theretofore or thereafter occurring. Any waiver, permit, consent or approval of any kind or character on the part of any party of any breach or default under this Agreement, or any waiver on the part of any party of any
provisions or conditions of this Agreement, must be in writing and shall be effective only to the extent specifically set forth in such writing. All remedies, either under this Agreement or by law or otherwise afforded to any party, shall be
cumulative and not alternative. 

  
 28 

 9.11. Entire Agreement. This Agreement (including the Exhibits hereto), the Restated
Certificate and the other Transaction Agreements constitute the full and entire understanding and agreement between the parties with respect to the subject matter hereof, and any other written or oral agreement relating to the subject matter hereof
existing between the parties are expressly canceled. 
 9.12. No Promotion. The Company agrees that it will not, and shall cause each
of its subsidiaries to not, without the prior written consent of the Purchaser, use in advertising, publicity, or otherwise the name of the Purchaser, nor any trade name, trademark, trade device, service mark, symbol or any abbreviation, contraction
or simulation thereof owned by the Purchaser or any of its Affiliates. The Company further agrees that it shall obtain the written consent of the Purchaser, which shall not be unreasonably withheld, prior to the Company’s issuance of any public
statement detailing the purchase of Shares by the Purchaser pursuant to this Agreement. Anything herein to the contrary notwithstanding, this Subsection 9.12 shall not be amended without the prior written consent of the Purchaser.
Notwithstanding the foregoing, this Agreement and any other agreement to which the Company and the Purchaser is a party may be filed by the Company with the Securities and Exchange Commission. 

9.13. Dispute Resolution. The parties (a) hereby irrevocably and unconditionally submit to the jurisdiction of the state courts of
the Commonwealth of Massachusetts and to the jurisdiction of the United States District Court for the District of Massachusetts for the purpose of any suit, action or other proceeding arising out of or based upon this Agreement, (b) agree not
to commence any suit, action or other proceeding arising out of or based upon this Agreement except in the state courts of the Commonwealth of Massachusetts or the United States District Court for the District of Massachusetts, and (c) hereby
waive, and agree not to assert, by way of motion, as a defense, or otherwise, in any such suit, action or proceeding, any claim that it is not subject personally to the jurisdiction of the above-named courts, that its property is exempt or immune
from attachment or execution, that the suit, action or proceeding is brought in an inconvenient forum, that the venue of the suit, action or proceeding is improper or that this Agreement or the subject matter hereof may not be enforced in or by such
court. 
 WAIVER OF JURY TRIAL: EACH PARTY HEREBY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS
AGREEMENT, THE OTHER TRANSACTION DOCUMENTS, THE SECURITIES OR THE SUBJECT MATTER HEREOF OR THEREOF. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL-ENCOMPASSING OF ANY AND ALL DISPUTES THAT MAY BE FILED IN ANY COURT AND THAT RELATE TO THE SUBJECT
MATTER OF THIS TRANSACTION, INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS, TORT CLAIMS (INCLUDING NEGLIGENCE), BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY CLAIMS. THIS SECTION HAS BEEN FULLY DISCUSSED BY EACH OF THE PARTIES HERETO
AND THESE PROVISIONS WILL NOT BE SUBJECT TO ANY EXCEPTIONS. EACH PARTY HERETO HEREBY FURTHER WARRANTS AND REPRESENTS THAT SUCH PARTY HAS REVIEWED THIS WAIVER WITH ITS LEGAL COUNSEL, AND THAT SUCH PARTY KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL
RIGHTS FOLLOWING CONSULTATION WITH LEGAL COUNSEL. 
 [the next page is the signature page] 

  
 29 

 IN WITNESS WHEREOF, the parties have executed this Series D Preferred Stock Purchase Agreement as
of the date first written above. 
  

			
	COMPANY:
	
	SERES HEALTH, INC.
		
	By:		/s/ Roger J. Pomerantz
	Name: Roger J. Pomerantz, M.D.
	Title: President and Chief Executive Officer
	
	 Address:
 161 First Street, Suite
2C
 Cambridge, MA 02142
 Facsimile Number:
617-945-0268

  

			
	PURCHASER:
	
	NESTLÉ HEALTH SCIENCE US HOLDINGS, INC.
		
	By:		/s/ Andrew Glass
	Name: Andrew Glass
	Title: Asst. Sec.
	
	 Address:
 Nestlé Health
Science US Holdings, Inc.
 900 Long Ridge Road, Building 2

Stamford, CT 06902
 Attention: Andrew Glass, Esq.

Facsimile Number: 480-379-5510
  

With a copy (which shall not constitute notice) to:
  

Nestlé Health Science S.A.
 Avenue Nestlé, 55

1800 Vevey
 Switzerland

Attention: General Counsel
 Facsimile Number:
41.21.927.2875

 SIGNATURE PAGE TO SERIES D PREFERRED STOCK PURCHASE AGREEMENT 

 EXHIBIT A 

FORM OF AMENDED AND RESTATED CERTIFICATE OF INCORPORATION 

 AMENDED AND RESTATED 

CERTIFICATE OF INCORPORATION 
 OF

 SERES HEALTH, INC. 
 (Pursuant
to Sections 242 and 245 of the 
 General Corporation Law of the State of Delaware) 

Seres Health, Inc., a corporation organized and existing under and by virtue of the provisions of the General Corporation Law of the
State of Delaware (the “General Corporation Law”), 
 DOES HEREBY CERTIFY: 

1. That the name of this corporation is Seres Health, Inc., and that this corporation was originally incorporated pursuant to the General
Corporation Law on October 18, 2010 under the name Newco LS21, Inc. 
 2. That the Board of Directors of this corporation duly adopted
resolutions proposing to amend and restate the Certificate of Incorporation of this corporation, declaring said amendment and restatement to be advisable and in the best interests of this corporation and its stockholders, and authorizing the
appropriate officers of this corporation to solicit the consent of the stockholders therefor, which resolution setting forth the proposed amendment and restatement is as follows: 

RESOLVED, that the Certificate of Incorporation of this corporation be amended and restated in its entirety to read as follows:

 FIRST: The name of this corporation is Seres Health, Inc. (the “Corporation”). 

SECOND: The address of the registered office of the Corporation in the State of Delaware is 1209 Orange Street, in the City of
Wilmington, County of New Castle 19801. The name of its registered agent at such address is The Corporation Trust Company. 

THIRD: The nature of the business or purposes to be conducted or promoted is to engage in any lawful act or activity for which
corporations may be organized under the General Corporation Law. 
 FOURTH: The total number of shares of all classes of stock
which the Corporation shall have authority to issue is 62,348,003 shares, consisting of (i) 38,000,000 shares of Common Stock, $0.001 par value per share (“Common Stock”), and (ii) 24,348,003 shares of Preferred Stock,
$0.001 par value per share (“Preferred Stock”), of which 8,230,997 shares are hereby designated “Series A Preferred Stock,” 2,339,319 shares are hereby designated “Series A-2 Preferred Stock,”
4,831,359 shares are hereby designated “Series B Preferred Stock,” 3,946,328 shares are hereby designated “Series C Preferred Stock,” 3,611,111 shares are hereby designated “Series D Preferred
Stock” and 1,388,889 shares are hereby designated “Series D-1 Preferred Stock.” 

 The following is a statement of the designations and the powers, privileges and rights, and the
qualifications, limitations or restrictions thereof in respect of each class of capital stock of the Corporation. 
  

	 	A.	COMMON STOCK 

 1. General. The voting, dividend and liquidation rights of the holders of
the Common Stock are subject to and qualified by the rights, powers and preferences of the holders of the Preferred Stock set forth herein. 

2. Voting. The holders of the Common Stock are entitled to one vote for each share of Common Stock held at all meetings of stockholders
(and written actions in lieu of meetings); provided, however, that, except as otherwise required by law, holders of Common Stock, as such, shall not be entitled to vote on any amendment to the Certificate of Incorporation that relates
solely to the terms of one or more outstanding series of Preferred Stock if the holders of such affected series are entitled, either separately or together with the holders of one or more other such series, to vote thereon pursuant to the
Certificate of Incorporation or pursuant to the General Corporation Law. The number of authorized shares of Common Stock may be increased or decreased (but not below the number of shares thereof then outstanding) by (in addition to any vote of the
holders of one or more series of Preferred Stock that may be required by the terms of the Certificate of Incorporation) the affirmative vote of the holders of shares of capital stock of the Corporation representing a majority of the votes
represented by all outstanding shares of capital stock of the Corporation entitled to vote, irrespective of the provisions of Section 242(b)(2) of the General Corporation Law. 

 

	 	B.	PREFERRED STOCK 

 The Series A Preferred Stock, the Series A-2 Preferred Stock, the Series B
Preferred Stock, the Series C Preferred Stock, the Series D Preferred Stock and the Series D-1 Preferred Stock shall have the following rights, preferences, powers, privileges and restrictions, qualifications and limitations. Unless otherwise
indicated, references to “Sections” or “Subsections” in this Part B of this Article Fourth refer to sections and subsections of Part B of this Article Fourth. 

1. Dividends. 
 From and
after the date of the issuance of any shares of Series A Preferred Stock, dividends at the rate per annum of eight percent (8%) of the Series A Original Purchase Price (as defined below) per share plus the amount of previously accrued dividends
shall accrue on such shares of Series A Preferred Stock (the “Series A Accruing Dividends”). From and after the date of the issuance of any shares of Series A-2 Preferred Stock, dividends at the rate per annum of eight percent
(8%) of the Series A-2 Original Purchase Price (as defined below) per share plus the amount of previously accrued dividends shall accrue on such shares of Series A-2 Preferred Stock (the “Series A-2 Accruing Dividends”). From
and after the date of the issuance of any shares of Series B Preferred Stock, dividends at the rate per annum of eight percent (8%) of the Series B Original Purchase Price (as defined below) per share plus the amount of previously accrued
dividends shall accrue on such shares of Series B Preferred Stock (the “Series B 

 
Accruing Dividends”). From and after the date of the issuance of any shares of Series C Preferred Stock, dividends at the rate per annum of eight percent (8%) of the Series C
Original Purchase Price (as defined below) per share plus the amount of previously accrued dividends shall accrue on such shares of Series C Preferred Stock (the “Series C Accruing Dividends”). From and after the date of the
issuance of any shares of Series D Preferred Stock, dividends at the rate per annum of eight percent (8%) of the Series D Original Purchase Price (as defined below) per share plus the amount of previously accrued dividends shall accrue on such
shares of Series D Preferred Stock (the “Series D Accruing Dividends”). From and after the date of the issuance of any shares of Series D-1 Preferred Stock, dividends at the rate per annum of eight percent (8%) of the Series
D-1 Original Purchase Price (as defined below) per share plus the amount of previously accrued dividends shall accrue on such shares of Series D-1 Preferred Stock (the “Series D-1 Accruing Dividends” and, together with the Series A
Accruing Dividends, the Series A-2 Accruing Dividends, the Series B Accruing Dividends, the Series C Accruing Dividends and the Series D Accruing Dividends, the “Accruing Dividends”). Accruing Dividends shall accrue from day to day,
whether or not declared, and shall be cumulative; provided however, that except as set forth in the following sentence of this Section 1 or in Subsection 2.1, such Accruing Dividends shall be payable only when, as,
and if declared by the Board of Directors and the Corporation shall be under no obligation to pay such Accruing Dividends. The Corporation shall not declare, pay or set aside any dividends on shares of any other class or series of capital stock of
the Corporation (other than dividends on shares of Common Stock payable in shares of Common Stock) unless (in addition to the obtaining of any consents required elsewhere in the Certificate of Incorporation) the holders of the Preferred Stock then
outstanding shall first receive, or simultaneously receive, a dividend on each outstanding share of the applicable series of Preferred Stock in an amount at least equal to the greater of (i) the amount of the aggregate Series A Accruing
Dividends, Series A-2 Accruing Dividends, Series B Accruing Dividends, Series C Accruing Dividends, Series D Accruing Dividends or Series D-1 Accruing Dividends, as the case may be, then accrued on the shares of the applicable series of Preferred
Stock and not previously paid and (ii) (A) in the case of a dividend on Common Stock or any class or series that is convertible into Common Stock, that dividend per share of the applicable series of Preferred Stock as would equal the
product of (1) the dividend payable on each share of such class or series determined, if applicable, as if all shares of such class or series had been converted into Common Stock and (2) the number of shares of Common Stock issuable upon
conversion of a share of the applicable series of Preferred Stock, in each case calculated on the record date for determination of holders entitled to receive such dividend or (B) in the case of a dividend on any class or series that is not
convertible into Common Stock, at a rate per share of the applicable series of Preferred Stock determined by (1) dividing the amount of the dividend payable on each share of such class or series of capital stock by the original issuance price
of such class or series of capital stock (subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to such class or series) and (2) multiplying such fraction
by an amount equal to the Series A Original Issue Price (as defined below), Series A-2 Original Issue Price (as defined below), Series B Original Issue Price (as defined below), Series C Original Issue Price (as defined below), Series D Original
Issue Price (as defined below) or Series D-1 Original Issue Price (as defined below), as applicable; provided that, if the Corporation declares, pays or sets aside, on the same date, a dividend on shares of more than one class or series of capital
stock of the Corporation, the dividend payable to the holders of 

 
Preferred Stock pursuant to this Section 1 shall be calculated based upon the dividend on the class or series of capital stock that would result in the highest Preferred Stock
dividend. The “Series A Original Issue Price” shall mean $0.79 per share, subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to the Series A
Preferred Stock. The “Series A-2 Original Issue Price” shall mean $1.78 per share, subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to the
Series A-2 Preferred Stock. The “Series B Original Issue Price” shall mean $2.20 per share, subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with
respect to the Series B Preferred Stock. The “Series C Original Issue Price” shall mean $12.1632 per share, subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar
recapitalization with respect to the Series C Preferred Stock. The “Series D Original Issue Price” shall mean $18.00 per share, subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other
similar recapitalization with respect to the Series D Preferred Stock. The “Series D-1 Original Issue Price” shall mean $18.00 per share, subject to appropriate adjustment in the event of any stock dividend, stock split, combination
or other similar recapitalization with respect to the Series D-1 Preferred Stock. 
 2. Liquidation, Dissolution or Winding Up; Certain
Mergers, Consolidations and Asset Sales. 
 2.1 Preferential Payments to Holders of Preferred Stock. In the event of any
voluntary or involuntary liquidation, dissolution or winding up of the Corporation or Deemed Liquidation Event (as defined below), the holders of shares of Preferred Stock then outstanding shall be entitled to be paid, on a pari passu basis, out of
the assets of the Corporation available for distribution to its stockholders before any payment shall be made to the holders of Common Stock by reason of their ownership thereof, an amount per share equal to (i) in the case of the Series A
Preferred Stock, the greater of (A) the Series A Original Issue Price, plus any Series A Accruing Dividends accrued but unpaid thereon, whether or not declared, together with any other dividends declared but unpaid thereon, and (B) such
amount per share as would have been payable had all shares of Preferred Stock been converted into Common Stock pursuant to Section 4 immediately prior to such liquidation, dissolution, winding up or Deemed Liquidation Event (the amount
payable pursuant to this clause (i) is hereinafter referred to as the “Series A Liquidation Amount”), (ii) in the case of the Series A-2 Preferred Stock, the greater of (A) the Series A-2 Original Issue Price, plus
any Series A-2 Accruing Dividends accrued but unpaid thereon, whether or not declared, together with any other dividends declared but unpaid thereon, and (B) such amount per share as would have been payable had all shares of Preferred Stock
been converted into Common Stock pursuant to Section 4 immediately prior to such liquidation, dissolution, winding up or Deemed Liquidation Event (the amount payable pursuant to this clause (ii) is hereinafter referred to as the
“Series A-2 Liquidation Amount”), (iii) in the case of the Series B Preferred Stock, the greater of (A) the Series B Original Issue Price, plus any Series B Accruing Dividends accrued but unpaid thereon, whether or not
declared, together with any other dividends declared but unpaid thereon, and (B) such amount per share as would have been payable had all shares of Preferred Stock been converted into Common Stock pursuant to Section 4 immediately
prior to such liquidation, dissolution, winding up or Deemed Liquidation Event 

 
(the amount payable pursuant to this clause (iii) is hereinafter referred to as the “Series B Liquidation Amount”), (iv) in the case of the Series C Preferred Stock,
the greater of (A) the Series C Original Issue Price, plus any Series C Accruing Dividends accrued but unpaid thereon, whether or not declared, together with any other dividends declared but unpaid thereon, and (B) such amount per share as
would have been payable had all shares of Preferred Stock been converted into Common Stock pursuant to Section 4 immediately prior to such liquidation, dissolution, winding up or Deemed Liquidation Event (the amount payable pursuant to
this clause (iv) is hereinafter referred to as the “Series C Liquidation Amount”), (v) in the case of the Series D Preferred Stock, the greater of (A) the Series D Original Issue Price, plus any Series D Accruing
Dividends accrued but unpaid thereon, whether or not declared, together with any other dividends declared but unpaid thereon, and (B) such amount per share as would have been payable had all shares of Preferred Stock been converted into Common
Stock pursuant to Section 4 immediately prior to such liquidation, dissolution, winding up or Deemed Liquidation Event (the amount payable pursuant to this clause (v) is hereinafter referred to as the “Series D Liquidation
Amount”) and (vi) in the case of the Series D-1 Preferred Stock, the greater of (A) the Series D-1 Original Issue Price, plus any Series D-1 Accruing Dividends accrued but unpaid thereon, whether or not declared, together with any
other dividends declared but unpaid thereon, and (B) such amount per share as would have been payable had all shares of Preferred Stock been converted into Common Stock pursuant to Section 4 immediately prior to such liquidation,
dissolution, winding up or Deemed Liquidation Event (the amount payable pursuant to this clause (vi) is hereinafter referred to as the “Series D-1 Liquidation Amount”). If upon any such liquidation, dissolution or winding up of
the Corporation or Deemed Liquidation Event, the assets of the Corporation available for distribution to its stockholders shall be insufficient to pay the holders of shares of Preferred Stock the full amount to which they shall be entitled under
this Subsection 2.1, the holders of shares of Preferred Stock shall share ratably in any distribution of the assets available for distribution in proportion to the respective amounts which would otherwise be payable in respect of the shares
held by them upon such distribution if all amounts payable on or with respect to such shares were paid in full. 
 2.2 Payments to
Holders of Common Stock. In the event of any voluntary or involuntary liquidation, dissolution or winding up of the Corporation or Deemed Liquidation Event, after the payment of all preferential amounts required to be paid to the holders of
shares of Preferred Stock, the remaining assets of the Corporation available for distribution to its stockholders shall be distributed among the holders of shares of Common Stock, pro rata based on the number of shares held by each such holder. 

2.3 Deemed Liquidation Events. 

2.3.1 Definition. Each of the following events shall be considered a “Deemed Liquidation Event” unless (i) the
holders of shares of Preferred Stock representing at least sixty percent (60%) of the voting power of the then outstanding shares of Preferred Stock, voting together as a separate class, and (ii) the holders of a majority of the then
outstanding shares of Series C Preferred Stock, voting as a separate class, elect otherwise by written notice sent to the Corporation at least ten (10) days prior to the effective date of any such event: 

(a) a merger or consolidation in which 

(i) the Corporation is a constituent party or 

(ii) a subsidiary of the Corporation is a constituent party and the Corporation issues shares of its capital stock pursuant to such merger or
consolidation, 

 except any such merger or consolidation involving the Corporation or a subsidiary in which the shares of capital
stock of the Corporation outstanding immediately prior to such merger or consolidation continue to represent, or are converted into or exchanged for shares of capital stock that represent, immediately following such merger or consolidation, a
majority, by voting power, of the capital stock of (1) the surviving or resulting corporation or (2) if the surviving or resulting corporation is a wholly owned subsidiary of another corporation immediately following such merger or
consolidation, the parent corporation of such surviving or resulting corporation (provided that, for the purpose of this Subsection 2.3.1, all shares of Common Stock issuable upon exercise of Options (as defined below) outstanding immediately
prior to such merger or consolidation or upon conversion of Convertible Securities (as defined below) outstanding immediately prior to such merger or consolidation shall be deemed to be outstanding immediately prior to such merger or consolidation
and, if applicable, converted or exchanged in such merger or consolidation on the same terms as the actual outstanding shares of Common Stock are converted or exchanged); or 

(b) the sale, lease, transfer, exclusive license or other disposition, in a single transaction or series of related transactions, by the
Corporation or any subsidiary of the Corporation of all or substantially all the assets of the Corporation and its subsidiaries taken as a whole, or the sale or disposition (whether by merger or otherwise) of one or more subsidiaries of the
Corporation if substantially all of the assets of the Corporation and its subsidiaries taken as a whole are held by such subsidiary or subsidiaries, except where such sale, lease, transfer, exclusive license or other disposition is to a wholly owned
subsidiary of the Corporation. 
 2.3.2 Effecting a Deemed Liquidation Event. 

(a) The Corporation shall not have the power to effect a Deemed Liquidation Event referred to in Subsection 2.3.1(a)(i) unless
the agreement or plan of merger or consolidation for such transaction (the “Merger Agreement”) provides that the consideration payable to the stockholders of the Corporation shall be allocated among the holders of capital stock of
the Corporation in accordance with Subsections 2.1 and 2.2. 
 (b) In the event of a Deemed Liquidation Event referred to in
Subsection 2.3.1(a)(ii) or 2.3.1(b), if the Corporation does not effect a dissolution of the Corporation under the General Corporation Law within 90 days after such Deemed Liquidation Event, then (i) the Corporation shall send a
written notice to each holder of Preferred Stock no later than the 90th day after the Deemed Liquidation Event advising such holders of their right (and the requirements to be met to secure such right) pursuant to the terms of the following clause
(ii) to require the redemption of such shares of Preferred Stock, and (ii) if the holders of shares of Preferred Stock representing at least sixty percent (60%) of the voting power of the then outstanding shares of Preferred Stock so
request in a written instrument delivered to the Corporation not later than 120 days after such Deemed Liquidation Event, the Corporation shall 

 
use the consideration received by the Corporation for such Deemed Liquidation Event (net of any retained liabilities associated with the assets sold or technology licensed, as determined in good
faith by the Board of Directors of the Corporation), together with any other assets of the Corporation available for distribution to its stockholders (the “Available Proceeds”), to the extent legally available therefor, on the 150th
day after such Deemed Liquidation Event (the “Redemption Date”), to redeem all outstanding shares of Preferred Stock at a price per share equal to, in the case of the Series A Preferred Stock, the Series A Liquidation Amount, in the
case of the Series A-2 Preferred Stock, the Series A-2 Liquidation Amount, in the case of the Series B Preferred Stock, the Series B Liquidation Amount, in the case of the Series C Preferred Stock, the Series C Liquidation Amount, in the case of the
Series D Preferred Stock, the Series D Liquidation Amount, and, in the case of the Series D-1 Preferred Stock, the Series D-1 Liquidation Amount. Notwithstanding the foregoing, in the event of a redemption pursuant to the preceding sentence, if the
Available Proceeds are not sufficient to redeem all outstanding shares of Preferred Stock, the Corporation shall redeem a pro rata portion of each holder’s shares of Preferred Stock to the fullest extent of such Available Proceeds, based on the
respective amounts which would otherwise be payable in respect of the shares to be redeemed if the Available Proceeds were sufficient to redeem all such shares, and shall redeem the remaining shares to have been redeemed as soon as practicable after
the Corporation has funds legally available therefor. The Corporation shall send written notice of the mandatory redemption (the “Redemption Notice”) to each holder of record of Preferred Stock not less than 40 days prior to the
Redemption Date. The Redemption Notice shall state: (1) the number of shares of each series of Preferred Stock held by the holder that the Corporation shall redeem on the Redemption Date specified in the Redemption Notice; (2) the
Redemption Date, the Series A Liquidation Amount, the Series A-2 Liquidation Amount, the Series B Liquidation Amount, the Series C Liquidation Amount, the Series D Liquidation Amount and the Series D-1 Liquidation Amount; (3) the date upon
which the holder’s right to convert such shares terminates (as determined in accordance with Subsection 4.1); and (4) that the holder is to surrender to the Corporation, in the manner and at the place designated, his, her or its
certificate or certificates representing the shares of Preferred Stock to be redeemed. On or before the Redemption Date, each holder of shares of Preferred Stock to be redeemed on the Redemption Date, unless, if applicable, such holder has exercised
his, her or its right to convert such shares as provided in Section 4, shall surrender the certificate or certificates representing such shares (or, if such registered holder alleges that such certificate has been lost, stolen or
destroyed, a lost certificate affidavit and agreement reasonably acceptable to the Corporation to indemnify the Corporation against any claim that may be made against the Corporation on account of the alleged loss, theft or destruction of such
certificate) to the Corporation, in the manner and at the place designated in the Redemption Notice, and thereupon the Series A Liquidation Amount, the Series A-2 Liquidation Amount, the Series B Liquidation Amount, the Series C Liquidation Amount,
the Series D Liquidation Amount and/or the Series D-1 Liquidation Amount, as the case may be, for such shares shall be payable to the order of the person whose name appears on such certificate or certificates as the owner thereof. In the event less
than all of the shares of Preferred Stock represented by a certificate are redeemed, a new certificate representing the unredeemed shares of Preferred Stock shall promptly be issued to such holder. If the Redemption Notice shall have been duly
given, and if on the Redemption Date the Series A Liquidation Amount, the Series A-2 Liquidation Amount, the Series B Liquidation Amount, the Series C Liquidation Amount, the Series D Liquidation Amount and/or the Series D-1 Liquidation Amount, as
the case may be, 

 
payable upon redemption of the shares of Preferred Stock to be redeemed on the Redemption Date is paid or tendered for payment or deposited with an independent payment agent so as to be available
therefor in a timely manner, then notwithstanding that the certificates evidencing any of the shares of Preferred Stock so called for redemption shall not have been surrendered, dividends with respect to such shares of Preferred Stock shall cease to
accrue after the Redemption Date and all rights with respect to such shares shall forthwith after the Redemption Date terminate, except only the right of the holders to receive the Series A Liquidation Amount, the Series A-2 Liquidation Amount, the
Series B Liquidation Amount, the Series C Liquidation Amount, the Series D Liquidation Amount and/or the Series D-1 Liquidation Amount, as the case may be, without interest upon surrender of their certificate or certificates therefor. Prior to the
distribution or redemption provided for in this Subsection 2.3.2(b), the Corporation shall not expend or dissipate the consideration received for such Deemed Liquidation Event, except to discharge expenses incurred in connection with such
Deemed Liquidation Event or in the ordinary course of business. 
 2.3.3 Amount Deemed Paid or Distributed. The amount deemed paid
or distributed to the holders of capital stock of the Corporation upon any such merger, consolidation, sale, transfer, exclusive license, other disposition or redemption shall be the cash or the value of the property, rights or securities paid or
distributed to such holders by the Corporation or the acquiring person, firm or other entity. The value of such property, rights or securities shall be determined in good faith by the Board of Directors of the Corporation, including the Preferred
Stock Director (as defined below). 
 2.3.4 Allocation of Escrow. In the event of a Deemed Liquidation Event pursuant to
Subsection 2.3.1(a)(i), if any portion of the consideration payable to the stockholders of the Corporation is placed into escrow and/or is payable to the stockholders of the Corporation subject to contingencies, the Merger Agreement shall
provide that (a) the portion of such consideration that is not placed in escrow and not subject to any contingencies (the “Initial Consideration”) shall be allocated among the holders of capital stock of the Corporation in
accordance with Subsections 2.1 and 2.2 as if the Initial Consideration were the only consideration payable in connection with such Deemed Liquidation Event and (b) any additional consideration which becomes payable to the
stockholders of the Corporation upon release from escrow or satisfaction of contingencies shall be allocated among the holders of capital stock of the Corporation in accordance with Subsections 2.1 and 2.2 after taking into account the
previous payment of the Initial Consideration as part of the same transaction. 
 3. Voting. 

3.1 General. On any matter presented to the stockholders of the Corporation for their action or consideration at any meeting of
stockholders of the Corporation (or by written consent of stockholders in lieu of meeting), each holder of outstanding shares of Preferred Stock shall be entitled to cast the number of votes equal to the number of whole shares of Common Stock into
which the shares of Preferred Stock held by such holder are convertible as of the record date for determining stockholders entitled to vote on such matter. Except as provided by law or by the other provisions of the Certificate of Incorporation,
holders of Preferred Stock shall vote together with the holders of Common Stock as a single class. Notwithstanding the foregoing, the holders of shares of Series D-1 Preferred Stock shall not be entitled to vote for the election of any director of
the Corporation. 

 3.2 Election of Directors. The holders of record of the shares of Series A Preferred
Stock, Series B Preferred Stock and/or Series C Preferred Stock (together, the “ABC Preferred Stock”), exclusively and as a separate class, shall be entitled to elect one (1) director of the Corporation (the “Preferred
Stock Director”) and the holders of record of the shares of Common Stock, exclusively and as a separate class, shall be entitled to elect one (1) director of the Corporation. Any director elected as provided in the preceding sentence
may be removed without cause by, and only by, the affirmative vote of the holders of the shares of the class or series of capital stock entitled to elect such director or directors, given either at a special meeting of such stockholders duly called
for that purpose or pursuant to a written consent of stockholders. If the holders of shares of ABC Preferred Stock or Common Stock, as the case may be, fail to elect a sufficient number of directors to fill all directorships for which they are
entitled to elect directors, voting exclusively and as a separate class, pursuant to the first sentence of this Subsection 3.2, then any directorship not so filled shall remain vacant until such time as the holders of the ABC Preferred Stock
or Common Stock, as the case may be, elect a person to fill such directorship by vote or written consent in lieu of a meeting; and no such directorship may be filled by stockholders of the Corporation other than by the stockholders of the
Corporation that are entitled to elect a person to fill such directorship, voting exclusively and as a separate class. The holders of record of the shares of Common Stock and of any other class or series of voting stock (including Series A Preferred
Stock, Series A-2 Preferred Stock, Series B Preferred Stock, Series C Preferred Stock and Series D Preferred Stock (together, the “Voting Preferred Stock”) other than the Series D-1 Preferred Stock, exclusively and voting
together as a single class (on an as-converted to Common Stock basis), shall be entitled to elect the balance of the total number of directors of the Corporation. At any meeting held for the purpose of electing a director, the presence in person or
by proxy of the holders of a majority of the outstanding shares of the class or series entitled to elect such director shall constitute a quorum for the purpose of electing such director. Except as otherwise provided in this Subsection 3.2, a
vacancy in any directorship filled by the holders of any class or series shall be filled only by vote or written consent in lieu of a meeting of the holders of such class or series or by any remaining director or directors elected by the holders of
such class or series pursuant to this Subsection 3.2. 
 3.3 Preferred Stock Protective Provisions. At any time when shares
of ABC Preferred Stock are outstanding, the Corporation shall not, either directly or indirectly by amendment, merger, consolidation or otherwise, do any of the following without (in addition to any other vote required by law or the Certificate of
Incorporation) the written consent or affirmative vote of the holders of shares of ABC Preferred Stock representing at least sixty percent (60%) of the voting power of the then outstanding shares of ABC Preferred Stock, given in writing or by
vote at a meeting, consenting or voting (as the case may be) separately as a class, and any such act or transaction entered into without such consent or vote shall be null and void ab initio, and of no force or effect: 

3.3.1 liquidate, dissolve or wind-up the business and affairs of the Corporation, effect any merger or consolidation or any other Deemed
Liquidation Event, or consent to any of the foregoing; 

 3.3.2 amend, alter or repeal any provision of the Certificate of Incorporation or Bylaws of the
Corporation; 
 3.3.3 create, or authorize the creation of, or issue or obligate itself to issue shares of, any additional class or series
of capital stock unless the same ranks junior to the Series A Preferred Stock, the Series A-2 Preferred Stock, the Series B Preferred Stock and the Series C Preferred Stock with respect to the distribution of assets on the liquidation, dissolution
or winding up of the Corporation, the payment of dividends and rights of redemption, or increase or decrease the authorized number of shares of Series A Preferred Stock, Series A-2 Preferred Stock, Series B Preferred Stock or Series C Preferred
Stock or increase the authorized number of shares of any additional class or series of capital stock unless the same ranks junior to the Series A Preferred Stock, the Series A-2 Preferred Stock, the Series B Preferred Stock and the Series C
Preferred Stock with respect to the distribution of assets on the liquidation, dissolution or winding up of the Corporation, the payment of dividends and rights of redemption; 

3.3.4 (i) reclassify, alter or amend any existing security of the Corporation that is pari passu with the Series A Preferred Stock, the
Series A-2 Preferred Stock, the Series B Preferred Stock and the Series C Preferred Stock in respect of the distribution of assets on the liquidation, dissolution or winding up of the Corporation, the payment of dividends or rights of redemption, if
such reclassification, alteration or amendment would render such other security senior to the Series A Preferred Stock, the Series A-2 Preferred Stock, the Series B Preferred Stock or the Series C Preferred Stock in respect of any such right,
preference or privilege, or (ii) reclassify, alter or amend any existing security of the Corporation that is junior to the Series A Preferred Stock, the Series A-2 Preferred Stock, the Series B Preferred Stock and the Series C Preferred Stock
in respect of the distribution of assets on the liquidation, dissolution or winding up of the Corporation, the payment of dividends or rights of redemption, if such reclassification, alteration or amendment would render such other security senior to
or pari passu with the Series A Preferred Stock, the Series A-2 Preferred Stock, the Series B Preferred Stock or the Series C Preferred Stock in respect of any such right, preference or privilege; 

3.3.5 purchase or redeem (or permit any subsidiary to purchase or redeem) or pay or declare any dividend or make any distribution on, any
shares of capital stock of the Corporation other than (i) redemptions of or dividends or distributions on the Preferred Stock as expressly authorized herein, (ii) dividends or other distributions payable on the Common Stock solely in the
form of additional shares of Common Stock and (iii) repurchases of stock from former employees, officers, directors, consultants or other persons who performed services for the Corporation or any subsidiary in connection with the cessation of
such employment or service at the lower of the original purchase price and the then-current fair market value thereof; 
 3.3.6 create, or
authorize the creation of, or issue, or authorize the issuance of, any debt security or permit any subsidiary to take any such action with respect to any debt security unless such debt security has received the prior approval of the Board of
Directors, including the approval of the Preferred Stock Director; 

 3.3.7 create, or hold capital stock in, any subsidiary that is not wholly owned (either directly
or through one or more other subsidiaries) by the Corporation, or sell, transfer or otherwise dispose of any capital stock of any direct or indirect subsidiary of the Corporation, or permit any direct or indirect subsidiary to sell, lease, transfer,
exclusively license or otherwise dispose (in a single transaction or series of related transactions) of all or substantially all of the assets of such subsidiary; or 

3.3.8 increase or decrease the authorized number of directors constituting the Board of Directors. 

3.4 Series C Preferred Stock Protective Provisions. At any time when shares of Series C Preferred Stock are outstanding, the
Corporation shall not, either directly or indirectly by amendment, merger, consolidation or otherwise, do any of the following without (in addition to any other vote required by law or the Certificate of Incorporation) the written consent or
affirmative vote of the holders of a majority of the then outstanding shares of Series C Preferred Stock, given in writing or by vote at a meeting, consenting or voting (as the case may be) separately as a class, and any such act or transaction
entered into without such consent or vote shall be null and void ab initio, and of no force or effect: 
 3.4.1 amend, alter or
repeal any provision of the Certificate of Incorporation or Bylaws of the Corporation in a manner that adversely affects the powers, preferences or privileges of the Series C Preferred Stock; 

3.4.2 purchase or redeem (or permit any subsidiary to purchase or redeem) or pay or declare any dividend or make any distribution on, any
shares of capital stock of the Corporation other than (i) redemptions of or dividends or distributions on the Preferred Stock as expressly authorized herein, (ii) dividends or other distributions payable on the Common Stock solely in the
form of additional shares of Common Stock and (iii) repurchases of stock from former employees, officers, directors, consultants or other persons who performed services for the Corporation or any subsidiary in connection with the cessation of
such employment or service at the lower of the original purchase price and the then-current fair market value thereof; 
 3.4.3 (i)
reclassify, alter or amend any existing security of the Corporation that is pari passu with the Series C Preferred Stock in respect of the distribution of assets on the liquidation, dissolution or winding up of the Corporation, the payment of
dividends or rights of redemption, if such reclassification, alteration or amendment would render such other security senior to the Series C Preferred Stock in respect of any such right, preference or privilege, or (ii) reclassify, alter or
amend any existing security of the Corporation that is junior to the Series C Preferred Stock in respect of the distribution of assets on the liquidation, dissolution or winding up of the Corporation, the payment of dividends or rights of
redemption, if such reclassification, alteration or amendment would render such other security senior to or pari passu with the Series C Preferred Stock in respect of any such right, preference or privilege; or 

3.4.4 increase or decrease the authorized number of shares of Series C Preferred Stock. 

 3.5 Series D Preferred Stock Protective Provisions. At any time when shares of Series D
Preferred Stock are outstanding, the Corporation shall not, either directly or indirectly by amendment, merger, consolidation or otherwise, do any of the following without (in addition to any other vote required by law or the Certificate of
Incorporation) the written consent or affirmative vote of the holders of a majority of the then outstanding shares of Series D Preferred Stock given in writing or by vote at a meeting, consenting or voting (as the case may be) separately as a class,
and any such act or transaction entered into without such consent or vote shall be null and void ab initio, and of no force or effect: 

3.5.1 amend, alter or repeal any provision of the Certificate of Incorporation or Bylaws of the Corporation in a manner that adversely
affects the powers, preferences or privileges of the Series D Preferred Stock; 
 3.5.2 purchase or redeem (or permit any subsidiary to
purchase or redeem) or pay or declare any dividend or make any distribution on, any shares of capital stock of the Corporation other than (i) redemptions of or dividends or distributions on the Preferred Stock as expressly authorized herein,
(ii) dividends or other distributions payable on the Common Stock solely in the form of additional shares of Common Stock, (iii) repurchases of stock from former employees, officers, directors, consultants or other persons who performed
services for the Corporation or any subsidiary in connection with the cessation of such employment or service at the lower of the original purchase price and the then-current fair market value thereof and (iv) purchases or redemptions of Series
D Preferred Stock or Series D-1 Preferred Stock by the Corporation pursuant to Section 6 of that certain Series D Stock Purchase Agreement, dated on or about December 19, 2014, by and between the Corporation and the investor named therein;

 3.5.3 (i) reclassify, alter or amend any existing security of the Corporation that is pari passu with the Series D Preferred Stock in
respect of the distribution of assets on the liquidation, dissolution or winding up of the Corporation, the payment of dividends or rights of redemption, if such reclassification, alteration or amendment would render such other security senior to
the Series D Preferred Stock in respect of any such right, preference or privilege, or (ii) reclassify, alter or amend any existing security of the Corporation that is junior to the Series D Preferred Stock in respect of the distribution of
assets on the liquidation, dissolution or winding up of the Corporation, the payment of dividends or rights of redemption, if such reclassification, alteration or amendment would render such other security senior to or pari passu with the Series D
Preferred Stock in respect of any such right, preference or privilege; or 
 3.5.4 increase or decrease the authorized number of shares of
Series D Preferred Stock. 
 3.6 Series D-1 Preferred Stock Protective Provisions. At any time when shares of Series D-1 Preferred
Stock are outstanding, the Corporation shall not, either directly or indirectly by amendment, merger, consolidation or otherwise, do any of the following without (in addition to any other vote required by law or the Certificate of Incorporation) the
written consent or affirmative vote of the holders of a majority of the then outstanding shares of Series D-1 Preferred Stock given in writing or by vote at a meeting, consenting or voting (as the case may be) separately as a class, and any such act
or transaction entered into without such consent or vote shall be null and void ab initio, and of no force or effect: 
 3.6.1
amend, alter or repeal any provision of the Certificate of Incorporation or Bylaws of the Corporation in a manner that adversely affects the powers, preferences or privileges of the Series D-1 Preferred Stock; 

 3.6.2 purchase or redeem (or permit any subsidiary to purchase or redeem) or pay or declare any
dividend or make any distribution on, any shares of capital stock of the Corporation other than (i) redemptions of or dividends or distributions on the Preferred Stock as expressly authorized herein, (ii) dividends or other distributions
payable on the Common Stock solely in the form of additional shares of Common Stock, (iii) repurchases of stock from former employees, officers, directors, consultants or other persons who performed services for the Corporation or any
subsidiary in connection with the cessation of such employment or service at the lower of the original purchase price and the then-current fair market value thereof and (iv) purchases or redemptions of Series D Preferred Stock or Series D-1
Preferred Stock by the Corporation pursuant to Section 6 of that certain Series D Stock Purchase Agreement, dated on or about December 19, 2014, by and between the Corporation and the investor named therein; 

3.6.3 (i) reclassify, alter or amend any existing security of the Corporation that is pari passu with the
Series D-1 Preferred Stock in respect of the distribution of assets on the liquidation, dissolution or winding up of the Corporation, the payment of dividends or rights of redemption, if such
reclassification, alteration or amendment would render such other security senior to the Series D-1 Preferred Stock in respect of any such right, preference or privilege, or (ii) reclassify, alter or amend any existing security of the
Corporation that is junior to the Series D-1 Preferred Stock in respect of the distribution of assets on the liquidation, dissolution or winding up of the Corporation, the payment of dividends or rights of redemption, if such reclassification,
alteration or amendment would render such other security senior to or pari passu with the Series D-1 Preferred Stock in respect of any such right, preference or privilege; or 

3.6.4 increase or decrease the authorized number of shares of Series D-1 Preferred Stock. 

4. Optional Conversion. 

The holders of the Voting Preferred Stock shall have conversion rights as follows (the “Conversion Rights”): 

4.1 Right to Convert. 

4.1.1 Conversion Ratios. 

(a) Each share of Series A Preferred Stock shall be convertible, at the option of the holder thereof, at any time and from time to time, and
without the payment of additional consideration by the holder thereof, into such number of fully paid and 

 
nonassessable shares of Common Stock as is determined by dividing the Series A Original Issue Price by the Series A Conversion Price (as defined below) in effect at the time of conversion. The
“Series A Conversion Price” shall initially be equal to $0.79. Such initial Series A Conversion Price, and the rate at which shares of Series A Preferred Stock may be converted into shares of Common Stock, shall be subject to
adjustment as provided below. 
 (b) Each share of Series A-2 Preferred Stock shall be convertible, at the option of the holder thereof, at
any time and from time to time, and without the payment of additional consideration by the holder thereof, into such number of fully paid and nonassessable shares of Common Stock as is determined by dividing the Series A-2 Original Issue Price by
the Series A-2 Conversion Price (as defined below) in effect at the time of conversion. The “Series A-2 Conversion Price” shall initially be equal to $1.78. Such initial Series A-2 Conversion Price, and the rate at which shares of
Series A-2 Preferred Stock may be converted into shares of Common Stock, shall be subject to adjustment as provided below. 
 (c) Each
share of Series B Preferred Stock shall be convertible, at the option of the holder thereof, at any time and from time to time, and without the payment of additional consideration by the holder thereof, into such number of fully paid and
nonassessable shares of Common Stock as is determined by dividing the Series B Original Issue Price by the Series B Conversion Price (as defined below) in effect at the time of conversion. The “Series B Conversion Price” shall
initially be equal to $2.20. Such initial Series B Conversion Price, and the rate at which shares of Series B Preferred Stock may be converted into shares of Common Stock, shall be subject to adjustment as provided below. 

(d) Each share of Series C Preferred Stock shall be convertible, at the option of the holder thereof, at any time and from time to time, and
without the payment of additional consideration by the holder thereof, into such number of fully paid and nonassessable shares of Common Stock as is determined by dividing the Series C Original Issue Price by the Series C Conversion Price (as
defined below) in effect at the time of conversion. The “Series C Conversion Price” shall initially be equal to $12.1632. Such initial Series C Conversion Price, and the rate at which shares of Series C Preferred Stock may be
converted into shares of Common Stock, shall be subject to adjustment as provided below. 
 (e) Each share of Series D Preferred Stock
shall be convertible, at the option of the holder thereof, at any time and from time to time, and without the payment of additional consideration by the holder thereof, into such number of fully paid and nonassessable shares of Common Stock as is
determined by dividing $12.1632 (subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to the Series D Preferred Stock) by the Series D Conversion Price (as
defined below) in effect at the time of conversion. The “Series D Conversion Price” shall initially be equal to $12.1632. Such initial Series D Conversion Price, and the rate at which shares of Series D Preferred Stock may be
converted into shares of Common Stock, shall be subject to adjustment as provided below. 
 (f) Shares of Series D-1 Preferred Stock shall
not be convertible at the option of the holder thereof. 

 4.1.2 Termination of Conversion Rights. In the event of a liquidation, dissolution or
winding up of the Corporation or a Deemed Liquidation Event, the Conversion Rights shall terminate at the close of business on the last full day preceding the date fixed for the payment of any such amounts distributable on such event to the holders
of Preferred Stock. 
 4.2 Fractional Shares. No fractional shares of Common Stock shall be issued upon conversion of the Voting
Preferred Stock. In lieu of any fractional shares to which the holder would otherwise be entitled, the Corporation shall pay cash equal to such fraction multiplied by the fair market value of a share of Common Stock as determined in good faith by
the Board of Directors of the Corporation, including the Preferred Stock Director. Whether or not fractional shares would be issuable upon such conversion shall be determined on the basis of the total number of shares of Voting Preferred Stock the
holder is at the time converting into Common Stock and the aggregate number of shares of Common Stock issuable upon such conversion. 
 4.3
Mechanics of Conversion. 
 4.3.1 Notice of Conversion. In order for a holder of Voting Preferred Stock to voluntarily
convert shares of Voting Preferred Stock into shares of Common Stock, such holder shall surrender the certificate or certificates for such shares of Voting Preferred Stock (or, if such registered holder alleges that such certificate has been lost,
stolen or destroyed, a lost certificate affidavit and agreement reasonably acceptable to the Corporation to indemnify the Corporation against any claim that may be made against the Corporation on account of the alleged loss, theft or destruction of
such certificate), at the office of the transfer agent for the Preferred Stock (or at the principal office of the Corporation if the Corporation serves as its own transfer agent), together with written notice that such holder elects to convert all
or any number of the shares of the Voting Preferred Stock represented by such certificate or certificates and, if applicable, any event on which such conversion is contingent. Such notice shall state such holder’s name or the names of the
nominees in which such holder wishes the certificate or certificates for shares of Common Stock to be issued. If required by the Corporation, certificates surrendered for conversion shall be endorsed or accompanied by a written instrument or
instruments of transfer, in form satisfactory to the Corporation, duly executed by the registered holder or his, her or its attorney duly authorized in writing. The close of business on the date of receipt by the transfer agent (or by the
Corporation if the Corporation serves as its own transfer agent) of such certificates (or lost certificate affidavit and agreement) and notice shall be the time of conversion (the “Conversion Time”), and the shares of Common Stock
issuable upon conversion of the shares represented by such certificate shall be deemed to be outstanding of record as of such date. The Corporation shall, as soon as practicable after the Conversion Time, (i) issue and deliver to such holder of
Voting Preferred Stock, or to his, her or its nominees, a certificate or certificates for the number of full shares of Common Stock issuable upon such conversion in accordance with the provisions hereof and a certificate for the number (if any) of
the shares of Voting Preferred Stock represented by the surrendered certificate that were not converted into Common Stock, (ii) pay in cash such amount as provided in Subsection 4.2 in lieu of any fraction of a share of Common Stock
otherwise issuable upon such conversion and (iii) pay all declared but unpaid dividends on the shares of Voting Preferred Stock converted. 

 4.3.2 Reservation of Shares of Common Stock. The Corporation shall at all times when
shares of Voting Preferred Stock shall be outstanding, reserve and keep available out of its authorized but unissued capital stock, for the purpose of effecting the conversion of the Voting Preferred Stock, such number of its duly authorized shares
of Common Stock as shall from time to time be sufficient to effect the conversion of all outstanding shares of Voting Preferred Stock; and if at any time the number of authorized but unissued shares of Common Stock shall not be sufficient to effect
the conversion of all then outstanding shares of Voting Preferred Stock, the Corporation shall take such corporate action as may be necessary to increase its authorized but unissued shares of Common Stock to such number of shares as shall be
sufficient for such purposes, including, without limitation, engaging in best efforts to obtain the requisite stockholder approval of any necessary amendment to the Certificate of Incorporation. Before taking any action which would cause an
adjustment reducing the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price or the Series D Conversion Price below the then par value of the shares of Common Stock issuable upon
conversion of the Series A Preferred Stock, the Series A-2 Preferred Stock, the Series B Preferred Stock, the Series C Preferred Stock or the Series D Preferred Stock, as the case may be, the Corporation will take any corporate action which may, in
the opinion of its counsel, be necessary in order that the Corporation may validly and legally issue fully paid and nonassessable shares of Common Stock at such adjusted Series A Conversion Price, Series A-2 Conversion Price, Series B Conversion
Price, Series C Conversion Price or Series D Conversion Price. 
 4.3.3 Reservation of Shares of Series D Preferred Stock. The
Corporation shall at all times when shares of Series D-1 Preferred Stock shall be outstanding, reserve and keep available out of its authorized but unissued capital stock, for the purpose of effecting the conversion of the Series D-1 Preferred
Stock, such number of its duly authorized shares of Series D Preferred Stock as shall from time to time be sufficient to effect the conversion of all outstanding shares of Series D-1 Preferred Stock; and if at any time the number of authorized but
unissued shares of Series D Preferred Stock shall not be sufficient to effect the conversion of all then outstanding shares of Series D-1 Preferred Stock, the Corporation shall take such corporate action as may be necessary to increase its
authorized but unissued shares of Series D Preferred Stock to such number of shares as shall be sufficient for such purposes, including, without limitation, engaging in best efforts to obtain the requisite stockholder approval of any necessary
amendment to the Certificate of Incorporation. 
 4.3.4 Effect of Conversion. All shares of Voting Preferred Stock which shall have
been surrendered for conversion as herein provided shall no longer be deemed to be outstanding and all rights with respect to such shares shall immediately cease and terminate at the Conversion Time, except only the right of the holders thereof to
receive shares of Common Stock in exchange therefor, to receive payment in lieu of any fraction of a share otherwise issuable upon such conversion as provided in Subsection 4.2 and to receive payment of any dividends declared but unpaid
thereon. Any shares of Voting Preferred Stock so converted shall be retired and cancelled and may not be reissued as shares of such series, and the Corporation may thereafter take such appropriate action (without the need for stockholder action) as
may be necessary to reduce the authorized number of shares of Voting Preferred Stock and of such series of Voting Preferred Stock accordingly. 

 4.3.5 No Further Adjustment. Upon any such conversion, no adjustment to the Series A
Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price or the Series D Conversion Price shall be made for any declared but unpaid dividends on the Series A Preferred Stock, the Series A-2
Preferred Stock, the Series B Preferred Stock, the Series C Preferred Stock or the Series D Preferred Stock, as the case may be, surrendered for conversion or on the Common Stock delivered upon conversion. No adjustment shall be made to the number
of shares of Series D Preferred Stock issued upon conversion of the Series D-1 Preferred Stock into Series D Preferred Stock for any declared but unpaid dividends on the Series D-1 Preferred Stock that is converted into Series D Preferred Stock.

 4.3.6 Taxes. The Corporation shall pay any and all issue and other similar taxes that may be payable in respect of any issuance
or delivery of shares of Common Stock upon conversion of shares of Voting Preferred Stock pursuant to this Section 4 or shares of Series D Preferred Stock upon conversion of shares of Series D-1 Preferred Stock pursuant to
Section 5. The Corporation shall not, however, be required to pay any tax which may be payable in respect of any transfer involved in the issuance and delivery of shares of Common Stock or Series D Preferred Stock, as the case may be, in
a name other than that in which the shares of Voting Preferred Stock or Series D-1 Preferred Stock, as the case may be, so converted were registered, and no such issuance or delivery shall be made unless and until the person or entity requesting
such issuance has paid to the Corporation the amount of any such tax or has established, to the satisfaction of the Corporation, that such tax has been paid. 

4.4 Adjustments to Conversion Price for Diluting Issues. 

4.4.1 Special Definitions. For purposes of this Article Fourth, the following definitions shall apply: 

(a) “Option” shall mean rights, options or warrants to subscribe for, purchase or otherwise acquire Common Stock or
Convertible Securities. 
 (b) “Series D Original Issue Date” shall mean the date on which the first share of Series D
Preferred Stock was issued. 
 (c) “Convertible Securities” shall mean any evidences of indebtedness, shares or other
securities directly or indirectly convertible into or exchangeable for Common Stock, but excluding Options. 
 (d) “Additional
Shares of Common Stock” shall mean all shares of Common Stock issued (or, pursuant to Subsection 4.4.3 below, deemed to be issued) by the Corporation after the Series D Original Issue Date and assuming, for this purpose, that all
issued and outstanding shares of Series D-1 Preferred Stock have been converted into Series D Preferred Stock pursuant to Subsection 5.1.3 on the Series D Original Issue Date, other than (1) the following shares of Common Stock and
(2) shares of Common Stock deemed issued pursuant to the following Options and Convertible Securities (clauses (1) and (2), collectively, “Exempted Securities”): 

 

	 	(i)	shares of Common Stock, Options or Convertible Securities issued as a dividend or distribution on Preferred Stock; 

	 	(ii)	shares of Common Stock, Options or Convertible Securities issued by reason of a dividend, stock split, split-up or other distribution on shares of Common Stock that is covered by Subsection 4.5, 4.6,
4.7 or 4.8; 

  

	 	(iii)	shares of Common Stock or Options issued to employees or directors of, or consultants or advisors to, the Corporation or any of its subsidiaries pursuant to a plan, agreement or arrangement approved by the Board of
Directors of the Corporation, including the Preferred Stock Director; 

  

	 	(iv)	shares of Common Stock issued in connection with the listing of the Common Stock on a National Securities Exchange (as defined in Subsection 5.1.1(a)); 

 

	 	(v)	shares of Common Stock or Convertible Securities actually issued upon the exercise of Options or shares of Common Stock actually issued upon the conversion or exchange of Convertible Securities, in each case provided
such issuance is pursuant to the terms of such Option or Convertible Security; 

  

	 	(vi)	shares of Common Stock, Options or Convertible Securities issued to banks, equipment lessors or other financial institutions, or to real property lessors, pursuant to a debt financing, equipment leasing or real property
leasing transaction approved by the Board of Directors of the Corporation, including the Preferred Stock Director; 

  

	 	(vii)	shares of Common Stock, Options or Convertible Securities issued to suppliers or third party service providers in connection with the provision of goods or services pursuant to transactions approved by the Board of
Directors of the Corporation, including the Preferred Stock Director; 

	 	(viii)	shares of Common Stock, Options or Convertible Securities issued pursuant to the acquisition of another corporation by the Corporation by merger, purchase of substantially all of the assets or other reorganization or to
a joint venture agreement, provided that such issuances are approved by the Board of Directors of the Corporation, including the Preferred Stock Director; or 

  

	 	(ix)	shares of Common Stock, Options or Convertible Securities issued in connection with sponsored research, collaboration, technology license, development, OEM, marketing or other similar agreements or strategic
partnerships approved by the Board of Directors of the Corporation, including the Preferred Stock Director. 

 4.4.2 No
Adjustment of Conversion Price. No adjustment in the Series A Conversion Price, the Series A-2 Conversion Price or the Series B Conversion Price shall be made as the result of the issuance or deemed issuance of Additional Shares of Common Stock
if the Corporation receives written notice from the holders of shares of Series A Preferred Stock, Series A-2 Preferred Stock and Series B Preferred Stock representing at least sixty percent (60%) of the voting power of the then outstanding
shares of Series A Preferred Stock, Series A-2 Preferred Stock and Series B Preferred Stock, voting together as a separate class, agreeing that no such adjustment shall be made as the result of the issuance or deemed issuance of such Additional
Shares of Common Stock. No adjustment in the Series C Conversion Price shall be made as the result of the issuance or deemed issuance of Additional Shares of Common Stock if the Corporation receives written notice from the holders of a majority of
the then outstanding shares of Series C Preferred Stock agreeing that no such adjustment shall be made as the result of the issuance or deemed issuance of such Additional Shares of Common Stock. No adjustment in the Series D Conversion Price shall
be made as the result of the issuance or deemed issuance of Additional Shares of Common Stock if the Corporation receives written notice from the holders of a majority of the then outstanding shares of Series D Preferred Stock agreeing that no such
adjustment shall be made as the result of the issuance or deemed issuance of such Additional Shares of Common Stock. 
 4.4.3 Deemed
Issue of Additional Shares of Common Stock. 
 (a) If the Corporation at any time or from time to time after the Series D Original
Issue Date shall issue any Options or Convertible Securities (excluding Options or Convertible Securities which are themselves Exempted Securities and 

 
shares of Series D Preferred Stock issued upon conversion of the Series D-1 Preferred Stock pursuant to Subsection 5.1.3) or shall fix a record date for the determination of holders of any
class of securities entitled to receive any such Options or Convertible Securities, then the maximum number of shares of Common Stock (as set forth in the instrument relating thereto, assuming the satisfaction of any conditions to exercisability,
convertibility or exchangeability but without regard to any provision contained therein for a subsequent adjustment of such number) issuable upon the exercise of such Options or, in the case of Convertible Securities and Options therefor, the
conversion or exchange of such Convertible Securities, shall be deemed to be Additional Shares of Common Stock issued as of the time of such issue or, in case such a record date shall have been fixed, as of the close of business on such record date.

 (b) If the terms of any Option or Convertible Security, the issuance of which resulted in an adjustment to the Series A Conversion
Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price or the Series D Conversion Price pursuant to the terms of Subsection 4.4.4, are revised as a result of an amendment to such terms or any
other adjustment pursuant to the provisions of such Option or Convertible Security (but excluding automatic adjustments to such terms pursuant to anti-dilution or similar provisions of such Option or Convertible Security) to provide for either
(1) any increase or decrease in the number of shares of Common Stock issuable upon the exercise, conversion and/or exchange of any such Option or Convertible Security or (2) any increase or decrease in the consideration payable to the
Corporation upon such exercise, conversion and/or exchange, then, effective upon such increase or decrease becoming effective, the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion
Price or the Series D Conversion Price, as the case may be, computed upon the original issue of such Option or Convertible Security (or upon the occurrence of a record date with respect thereto) shall be readjusted to such Series A Conversion Price,
Series A-2 Conversion Price, Series B Conversion Price, Series C Conversion Price or Series D Conversion Price as would have been obtained had such revised terms been in effect upon the original date of issuance of such Option or Convertible
Security. Notwithstanding the foregoing, no readjustment pursuant to this clause (b) shall have the effect of increasing the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C
Conversion Price or the Series D Conversion Price to an amount which exceeds the lower of (i) the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price or the Series D
Conversion Price, as the case may be, in effect immediately prior to the original adjustment made as a result of the issuance of such Option or Convertible Security and (ii) the Series A Conversion Price, the Series A-2 Conversion Price, the
Series B Conversion Price, the Series C Conversion Price or the Series D Conversion Price, as the case may be, that would have resulted from any issuances of Additional Shares of Common Stock (other than deemed issuances of Additional Shares of
Common Stock as a result of the issuance of such Option or Convertible Security) between the original adjustment date and such readjustment date. 

(c) If the terms of any Option or Convertible Security (excluding Options or Convertible Securities which are themselves Exempted
Securities), the issuance of which did not result in an adjustment to the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price or the Series D

 
Conversion Price pursuant to the terms of Subsection 4.4.4 (either because the consideration per share (determined pursuant to Subsection 4.4.5) of the Additional Shares of Common
Stock subject thereto was equal to or greater than the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price or the Series D Conversion Price, as the case may be, then in effect, or
because such Option or Convertible Security was issued before the Series D Original Issue Date), are revised after the Series D Original Issue Date as a result of an amendment to such terms or any other adjustment pursuant to the provisions of such
Option or Convertible Security (but excluding automatic adjustments to such terms pursuant to anti-dilution or similar provisions of such Option or Convertible Security) to provide for either (1) any increase in the number of shares of Common
Stock issuable upon the exercise, conversion or exchange of any such Option or Convertible Security or (2) any decrease in the consideration payable to the Corporation upon such exercise, conversion or exchange, then such Option or Convertible
Security, as so amended or adjusted, and the Additional Shares of Common Stock subject thereto (determined in the manner provided in Subsection 4.4.3(a) shall be deemed to have been issued effective upon such increase or decrease
becoming effective. 
 (d) Upon the expiration or termination of any unexercised Option or unconverted or unexchanged Convertible Security
(or portion thereof) which resulted (either upon its original issuance or upon a revision of its terms) in an adjustment to the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price
or the Series D Conversion Price pursuant to the terms of Subsection 4.4.4, the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price and/or the Series D Conversion Price, as
the case may be, shall be readjusted to such Series A Conversion Price, Series A-2 Conversion Price, Series B Conversion Price, Series C Conversion Price or Series D Conversion Price, as the case may be, as would have been obtained had such Option
or Convertible Security (or portion thereof) never been issued. 
 (e) If the number of shares of Common Stock issuable upon the exercise,
conversion and/or exchange of any Option or Convertible Security, or the consideration payable to the Corporation upon such exercise, conversion and/or exchange, is calculable at the time such Option or Convertible Security is issued or amended but
is subject to adjustment based upon subsequent events, any adjustment to the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price or the Series D Conversion Price provided for in
this Subsection 4.4.3 shall be effected at the time of such issuance or amendment based on such number of shares or amount of consideration without regard to any provisions for subsequent adjustments (and any subsequent adjustments shall be
treated as provided in clauses (b) and (c) of this Subsection 4.4.3). If the number of shares of Common Stock issuable upon the exercise, conversion and/or exchange of any Option or Convertible Security, or the consideration payable
to the Corporation upon such exercise, conversion and/or exchange, cannot be calculated at all at the time such Option or Convertible Security is issued or amended, any adjustment to the Series A Conversion Price, the Series A-2 Conversion Price,
the Series B Conversion Price, the Series C Conversion Price or the Series D Conversion Price that would result under the terms of this Subsection 4.4.3 at the time of such issuance or amendment shall instead be effected at the time such
number of shares and/or 

 
amount of consideration is first calculable (even if subject to subsequent adjustments), assuming for purposes of calculating such adjustment to the Series A Conversion Price, the Series A-2
Conversion Price, the Series B Conversion Price, the Series C Conversion Price or the Series D Conversion Price that such issuance or amendment took place at the time such calculation can first be made. 

4.4.4 Adjustment of Conversion Price Upon Issuance of Additional Shares of Common Stock. In the event the Corporation shall at any
time after the Series D Original Issue Date issue Additional Shares of Common Stock (including Additional Shares of Common Stock deemed to be issued pursuant to Subsection 4.4.3), without consideration or for a consideration per share less
than the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price and/or the Series D Conversion Price, each as in effect immediately prior to such issue, then the Series A Conversion
Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price and/or the Series D Conversion Price, as the case may be, shall be reduced, concurrently with such issue, to a price (calculated to the nearest
one-hundredth of a cent) determined in accordance with the following formula: 
 CP2
= CP1 * (A + B) ÷ (A + C). 
 For purposes of the foregoing formula, the following
definitions shall apply: 
 (a) “CP2” shall mean (1) in the case of
an adjustment to the Series A Conversion Price, the Series A Conversion Price in effect immediately after such issue of Additional Shares of Common Stock, (2) in the case of an adjustment to the Series A-2 Conversion Price, the Series A-2
Conversion Price in effect immediately after such issue of Additional Shares of Common Stock, (3) in the case of an adjustment to the Series B Conversion Price, the Series B Conversion Price in effect immediately after such issue of Additional
Shares of Common Stock, (4) in the case of an adjustment to the Series C Conversion Price, the Series C Conversion Price in effect immediately after such issue of Additional Shares of Common Stock and (5) in the case of an adjustment to
the Series D Conversion Price, the Series D Conversion Price in effect immediately after such issue of Additional Shares of Common Stock; 

(b) “CP1” shall mean (1) in the case of an adjustment to the Series A
Conversion Price, the Series A Conversion Price in effect immediately prior to such issue of Additional Shares of Common Stock, (2) in the case of an adjustment to the Series A-2 Conversion Price, the Series A-2 Conversion Price in effect
immediately prior to such issue of Additional Shares of Common Stock, (3) in the case of an adjustment to the Series B Conversion Price, the Series B Conversion Price in effect immediately prior to such issue of Additional Shares of Common
Stock, (4) in the case of an adjustment to the Series C Conversion Price, the Series C Conversion Price in effect immediately prior to such issue of Additional Shares of Common Stock and (5) in the case of an adjustment to the Series D
Conversion Price, the Series D Conversion Price in effect immediately prior to such issue of Additional Shares of Common Stock; 
 (c)
“A” shall mean the number of shares of Common Stock outstanding immediately prior to such issue of Additional Shares of Common Stock 

 
(treating for this purpose as outstanding all shares of Common Stock issuable upon exercise of Options outstanding immediately prior to such issue or upon conversion or exchange of Convertible
Securities (including the Preferred Stock) outstanding (assuming exercise of any outstanding Options therefor and conversion of all Series D-1 Preferred Stock into Series D Preferred Stock pursuant to Subsection 5.1.3) immediately prior to
such issue); 
 (d) “B” shall mean the number of shares of Common Stock that would have been issued if such Additional Shares of
Common Stock had been issued at a price per share equal to CP1 (determined by dividing the aggregate consideration received by the Corporation in respect of such issue by CP1); and 
 (e) “C” shall mean the number of such Additional Shares of Common
Stock issued in such transaction. 
 4.4.5 Determination of Consideration. For purposes of this Subsection 4.4, the
consideration received by the Corporation for the issue of any Additional Shares of Common Stock shall be computed as follows: 
 (a)
Cash and Property: Such consideration shall: 
  

	 	(i)	insofar as it consists of cash, be computed at the aggregate amount of cash received by the Corporation, excluding amounts paid or payable for accrued interest; 

 

	 	(ii)	insofar as it consists of property other than cash, be computed at the fair market value thereof at the time of such issue, as determined in good faith by the Board of Directors of the Corporation, including the
Preferred Stock Director; and 

  

	 	(iii)	in the event Additional Shares of Common Stock are issued together with other shares or securities or other assets of the Corporation for consideration which covers both, be the proportion of such consideration so
received, computed as provided in clauses (i) and (ii) above, as determined in good faith by the Board of Directors of the Corporation, including the Preferred Stock Director. 

(b) Options and Convertible Securities. The consideration per share received by the Corporation for Additional Shares of Common Stock
deemed to have been issued pursuant to Subsection 4.4.3, relating to Options and Convertible Securities, shall be determined by dividing 

	 	(i)	the total amount, if any, received or receivable by the Corporation as consideration for the issue of such Options or Convertible Securities, plus the minimum aggregate amount of additional consideration (as set forth
in the instruments relating thereto, without regard to any provision contained therein for a subsequent adjustment of such consideration) payable to the Corporation upon the exercise of such Options or the conversion or exchange of such Convertible
Securities, or in the case of Options for Convertible Securities, the exercise of such Options for Convertible Securities and the conversion or exchange of such Convertible Securities, by 

 

	 	(ii)	the maximum number of shares of Common Stock (as set forth in the instruments relating thereto, without regard to any provision contained therein for a subsequent adjustment of such number) issuable upon the exercise of
such Options or the conversion or exchange of such Convertible Securities, or in the case of Options for Convertible Securities, the exercise of such Options for Convertible Securities and the conversion or exchange of such Convertible Securities.

 4.4.6 Multiple Closing Dates. In the event the Corporation shall issue on more than one date Additional Shares of
Common Stock that are a part of one transaction or a series of related transactions and that would result in an adjustment to the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion
Price and/or the Series D Conversion Price pursuant to the terms of Subsection 4.4.4, and such issuance dates occur within a period of no more than 90 days from the first such issuance to the final such issuance, then, upon the final such
issuance, the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price and/or the Series D Conversion Price, as the case may be, shall be readjusted to give effect to all such issuances
as if they occurred on the date of the first such issuance (and without giving effect to any additional adjustments as a result of any such subsequent issuances within such period). 

4.5 Adjustment for Stock Splits and Combinations. If the Corporation shall at any time or from time to time after the Series D
Original Issue Date effect a subdivision of the outstanding Common Stock, the Series A Conversion Price, the Series A-2 Conversion 

 
Price, the Series B Conversion Price, the Series C Conversion Price and the Series D Conversion Price, each as in effect immediately before such subdivision, shall be proportionately decreased so
that the number of shares of Common Stock issuable on conversion of each share of such series shall be increased in proportion to such increase in the aggregate number of shares of Common Stock outstanding. If the Corporation shall at any time or
from time to time after the Series D Original Issue Date combine the outstanding shares of Common Stock, the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price and the Series D
Conversion Price, each as in effect immediately before such combination, shall be proportionately increased so that the number of shares of Common Stock issuable on conversion of each share of such series shall be decreased in proportion to such
decrease in the aggregate number of shares of Common Stock outstanding. Any adjustment under this subsection shall become effective at the close of business on the date the subdivision or combination becomes effective. 

4.6 Adjustment for Certain Dividends and Distributions. In the event the Corporation at any time or from time to time after the Series
D Original Issue Date shall make or issue, or fix a record date for the determination of holders of Common Stock entitled to receive, a dividend or other distribution payable on the Common Stock in additional shares of Common Stock, then and in each
such event the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price and the Series D Conversion Price, each as in effect immediately before such event, shall be decreased as of the
time of such issuance or, in the event such a record date shall have been fixed, as of the close of business on such record date, by multiplying the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the
Series C Conversion Price and the Series D Conversion Price, as the case may be, then in effect by a fraction: 
 (1) the numerator of
which shall be the total number of shares of Common Stock issued and outstanding immediately prior to the time of such issuance or the close of business on such record date, and 

(2) the denominator of which shall be the total number of shares of Common Stock issued and outstanding immediately prior to the time of such
issuance or the close of business on such record date plus the number of shares of Common Stock issuable in payment of such dividend or distribution. 

Notwithstanding the foregoing, (a) if such record date shall have been fixed and such dividend is not fully paid or if such distribution is not fully
made on the date fixed therefor, the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price and the Series D Conversion Price, as the case may be, shall be recomputed accordingly as
of the close of business on such record date and thereafter the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price and the Series D Conversion Price as the case may be, shall be
adjusted pursuant to this subsection as of the time of actual payment of such dividends or distributions; and (b) no such adjustment shall be made with respect to the Series A Conversion Price, the Series A-2 Conversion Price, the Series B
Conversion Price, the Series C Conversion Price or the Series D Conversion Price if the holders of the applicable series of Preferred Stock simultaneously receive a dividend or other distribution of shares of Common Stock in a number

 
equal to the number of shares of Common Stock as they would have received if all outstanding shares of the applicable series of Preferred Stock had been converted into Common Stock on the date of
such event. 
 4.7 Adjustments for Other Dividends and Distributions. In the event the Corporation at any time or from time to time
after the Series D Original Issue Date shall make or issue, or fix a record date for the determination of holders of Common Stock entitled to receive, a dividend or other distribution payable in securities of the Corporation (other than a
distribution of shares of Common Stock in respect of outstanding shares of Common Stock) or in other property and the provisions of Section 1 do not apply to such dividend or distribution, then and in each such event the holders of
Preferred Stock shall receive, simultaneously with the distribution to the holders of Common Stock, a dividend or other distribution of such securities or other property in an amount equal to the amount of such securities or other property as they
would have received if all outstanding shares of Preferred Stock had been converted into Common Stock on the date of such event. 
 4.8
Adjustment for Merger or Reorganization, etc. Subject to the provisions of Subsection 2.3, if there shall occur any reorganization, recapitalization, reclassification, consolidation or merger involving the Corporation in which the
Common Stock (but not the Preferred Stock) is converted into or exchanged for securities, cash or other property (other than a transaction covered by Subsections 4.5, 4.6 or 4.7), then, following any such reorganization,
recapitalization, reclassification, consolidation or merger, each share of Preferred Stock shall thereafter be convertible in lieu of the Common Stock into which it was convertible prior to such event into the kind and amount of securities, cash or
other property which a holder of the number of shares of Common Stock of the Corporation issuable upon conversion of one share of the applicable series of Preferred Stock immediately prior to such reorganization, recapitalization, reclassification,
consolidation or merger would have been entitled to receive pursuant to such transaction; and, in such case, appropriate adjustment (as determined in good faith by the Board of Directors of the Corporation, including the Preferred Stock Director)
shall be made in the application of the provisions in this Section 4 with respect to the rights and interests thereafter of the holders of the applicable series of Preferred Stock, to the end that the provisions set forth in this
Section 4 (including provisions with respect to changes in and other adjustments of the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price or the Series D Conversion
Price, as the case may be) shall thereafter be applicable, as nearly as reasonably may be, in relation to any securities or other property thereafter deliverable upon the conversion of the applicable series of Preferred Stock. 

4.9 Certificate as to Adjustments. Upon the occurrence of each adjustment or readjustment of the Series A Conversion Price, the Series
A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price and/or the Series D Conversion Price pursuant to this Section 4, the Corporation at its expense shall, as promptly as reasonably practicable, compute such
adjustment or readjustment in accordance with the terms hereof and furnish to each holder of the applicable series of Preferred Stock a certificate setting forth such adjustment or readjustment (including the kind and amount of securities, cash or
other property into which the applicable series of Preferred Stock is convertible) and showing in detail the facts 

 
upon which such adjustment or readjustment is based. The Corporation shall, as promptly as reasonably practicable after the written request at any time of any holder of Preferred Stock, furnish
or cause to be furnished to such holder a certificate setting forth (i) the Series A Conversion Price, the Series A-2 Conversion Price, the Series B Conversion Price, the Series C Conversion Price and/or the Series D Conversion Price, as the
case may be, then in effect and (ii) the number of shares of Common Stock and the amount, if any, of other securities, cash or property which then would be received upon the conversion of the applicable series of Preferred Stock. 

4.10 Notice of Record Date. In the event: 

(a) the Corporation shall take a record of the holders of its Common Stock (or other capital stock or securities at the time issuable upon
conversion of the Preferred Stock) for the purpose of entitling or enabling them to receive any dividend or other distribution, or to receive any right to subscribe for or purchase any shares of capital stock of any class or any other securities, or
to receive any other security; or 
 (b) of any capital reorganization of the Corporation, any reclassification of the Common Stock of the
Corporation, or any Deemed Liquidation Event; or 
 (c) of the voluntary or involuntary dissolution, liquidation or winding-up of the
Corporation, 
 then, and in each such case, the Corporation will send or cause to be sent to the holders of the Preferred Stock a notice specifying, as the
case may be, (i) the record date for such dividend, distribution or right, and the amount and character of such dividend, distribution or right, or (ii) the effective date on which such reorganization, reclassification, consolidation,
merger, transfer, dissolution, liquidation or winding-up is proposed to take place, and the time, if any is to be fixed, as of which the holders of record of Common Stock (or such other capital stock or securities at the time issuable upon the
conversion of the Preferred Stock) shall be entitled to exchange their shares of Common Stock (or such other capital stock or securities) for securities or other property deliverable upon such reorganization, reclassification, consolidation, merger,
transfer, dissolution, liquidation or winding-up, and the amount per share and character of such exchange applicable to the Preferred Stock and the Common Stock. Such notice shall be sent at least ten (10) days prior to the record date or
effective date for the event specified in such notice. 
 5. Mandatory Conversion. 

5.1 Trigger Events. 

5.1.1 Upon either (a) the listing of shares of Common Stock on the New York Stock Exchange, the NYSE MKT, the NASDAQ Stock Market, the
NASDAQ Global Select Market, the NASDAQ Global Market or the NASDAQ Capital Market or any successor thereto (each a “National Securities Exchange”) or (b) the date and time, or the occurrence of an event, specified by vote or
written consent of both (i) the holders of shares of ABC Preferred Stock representing at least sixty percent (60%) of the voting power of the then 

 
outstanding shares of ABC Preferred Stock, voting together as a separate class, and (ii) the holders of a majority of the then outstanding shares of Series C Preferred Stock (the time of
such listing or the date and time specified or the time of the event specified in such vote or written consent is referred to herein as the “ABC Mandatory Conversion Time”), (A) all outstanding shares of ABC Preferred Stock
shall automatically be converted into shares of Common Stock, at the then effective conversion rate and (B) such shares may not be reissued by the Corporation. 

5.1.2 Upon either (a) the listing of shares of Common Stock on a National Securities Exchange or (b) the date and time, or the
occurrence of an event, specified by vote or written consent of the holders of a majority of the then outstanding shares of Series D Preferred Stock (the time of such listing or the date and time specified or the time of the event specified in such
vote or written consent is referred to herein as the “Series D Mandatory Conversion Time”), (A) all outstanding shares of Series D Preferred Stock shall automatically be converted into shares of Common Stock, at the then
effective conversion rate and (B) such shares may not be reissued by the Corporation. 
 5.1.3 Upon either (i) the expiration of
the applicable waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of 1976, as amended (the “HSR Act”) such that a holder of Series D-1 Preferred Stock could acquire shares of Series D Preferred Stock issuable upon
conversion of the Series D-1 Preferred Stock in compliance with the HSR Act or (ii) if applicable, a transfer of shares of Series D-1 Preferred Stock to a person that would not be required to make a filing under the HSR Act to acquire the
shares of Series D Preferred Stock issuable upon conversion of such shares of Series D-1 Preferred Stock or the waiting period under the HSR Act applicable to such person acquiring such shares of Series D Preferred Stock has expired (either such
event, a “Series D-1 Triggering Event”, and the date and time of such event is referred to herein as the “Series D-1 Mandatory Conversion Time”), each share of Series D-1 Preferred Stock held by such holder shall
automatically be converted into one (1) share of Series D Preferred Stock, subject to appropriate adjustment in the event of any stock dividend, stock split, combination or other similar recapitalization with respect to either the Series D
Preferred Stock or the Series D-1 Preferred Stock. The Corporation shall be sent written notice of any Series D-1 Triggering Event. Each holder of record of shares of Series D-1 Preferred Stock that has been or will be converted at a Series D-1
Mandatory Conversion Time shall be sent written notice of such Series D-1 Mandatory Conversion Time and the place designated for mandatory conversion of any shares of Series D-1 Preferred Stock pursuant to this Subsection 5.1.3. Such
notice need not be sent in advance of the occurrence of any Series D-1 Mandatory Conversion Time. Upon receipt of such notice, a holder of shares of Series D-1 Preferred Stock converted at any Series D-1 Mandatory Conversion Time shall surrender
his, her or its certificate or certificates for all such shares (or, if such holder alleges that such certificate has been lost, stolen or destroyed, a lost certificate affidavit and agreement reasonably acceptable to the Corporation to indemnify
the Corporation against any claim that may be made against the Corporation on account of the alleged loss, theft or destruction of such certificate) to the Corporation at the place designated in such notice. If so required by the Corporation,
certificates surrendered for conversion shall be endorsed or accompanied by written instrument or instruments of transfer, in form satisfactory to the Corporation, duly executed by the registered holder or by his, her or its attorney duly authorized
in writing. All rights with respect to the Series D-1 Preferred Stock converted pursuant to this Subsection 5.1.3, including the rights, if 

 
any, to receive notices and vote (other than as a holder of Series D Preferred Stock), will terminate at the applicable Series D-1 Mandatory Conversion Time (notwithstanding the failure of the
holder or holders thereof to surrender the certificates at or prior to such time), except only the rights of the holders thereof, upon surrender of their certificate or certificates (or lost certificate affidavit and agreement) therefor, to receive
the items provided for in the next sentence of this Subsection 5.1.3. As soon as practicable after a Series D-1 Mandatory Conversion Time and the surrender of the certificate or certificates (or lost certificate affidavit and agreement) for
Series D-1 Preferred Stock, the Corporation shall issue and deliver to such holder, or to his, her or its nominees, a certificate or certificates for the number of full shares of Series D Preferred Stock issuable on such conversion in accordance
with the provisions hereof and the payment of any declared but unpaid dividends on the shares of Series D-1 Preferred Stock converted. Such Series D-1 Preferred Stock shall be retired and cancelled and may not be reissued as shares of such series,
and the Corporation may thereafter take such appropriate action (without the need for stockholder action) as may be necessary to reduce the authorized number of shares of Series D-1 Preferred Stock accordingly. 

5.2 Mandatory Conversion Procedural Requirements. 

5.2.1 All holders of record of shares of ABC Preferred Stock shall be sent written notice of the ABC Mandatory Conversion Time and the place
designated for mandatory conversion of all such shares of ABC Preferred Stock pursuant to Subsection 5.1.1. Such notice need not be sent in advance of the occurrence of the ABC Mandatory Conversion Time. Upon receipt of such notice, each
holder of shares of ABC Preferred Stock shall surrender his, her or its certificate or certificates for all such shares (or, if such holder alleges that such certificate has been lost, stolen or destroyed, a lost certificate affidavit and agreement
reasonably acceptable to the Corporation to indemnify the Corporation against any claim that may be made against the Corporation on account of the alleged loss, theft or destruction of such certificate) to the Corporation at the place designated in
such notice. If so required by the Corporation, certificates surrendered for conversion shall be endorsed or accompanied by written instrument or instruments of transfer, in form satisfactory to the Corporation, duly executed by the registered
holder or by his, her or its attorney duly authorized in writing. All rights with respect to the ABC Preferred Stock converted pursuant to Subsection 5.1.1, including the rights, if any, to receive notices and vote (other than as a holder of
Common Stock), will terminate at the ABC Mandatory Conversion Time (notwithstanding the failure of the holder or holders thereof to surrender the certificates at or prior to such time), except only the rights of the holders thereof, upon surrender
of their certificate or certificates (or lost certificate affidavit and agreement) therefor, to receive the items provided for in the next sentence of this Subsection 5.2.1. As soon as practicable after the ABC Mandatory Conversion Time and
the surrender of the certificate or certificates (or lost certificate affidavit and agreement) for ABC Preferred Stock, the Corporation shall issue and deliver to such holder, or to his, her or its nominees, a certificate or certificates for the
number of full shares of Common Stock issuable on such conversion in accordance with the provisions hereof, together with cash as provided in Subsection 4.2 in lieu of any fraction of a share of Common Stock otherwise issuable upon such
conversion and the payment of any declared but unpaid dividends on the shares of ABC Preferred Stock converted. Such ABC Preferred Stock shall be retired and cancelled and may not be reissued as shares of such series, and the Corporation may
thereafter take such appropriate action (without the need for stockholder action) as may be necessary to reduce the authorized number of shares of each applicable series of ABC Preferred Stock accordingly. 

 5.2.2 All holders of record of shares of Series D Preferred Stock shall be sent written notice
of the Series D Mandatory Conversion Time and the place designated for mandatory conversion of all such shares of Series D Preferred Stock pursuant to Section 5.1.2. Such notice need not be sent in advance of the occurrence of the Series
D Mandatory Conversion Time. Upon receipt of such notice, each holder of shares of Series D Preferred Stock shall surrender his, her or its certificate or certificates for all such shares (or, if such holder alleges that such certificate has been
lost, stolen or destroyed, a lost certificate affidavit and agreement reasonably acceptable to the Corporation to indemnify the Corporation against any claim that may be made against the Corporation on account of the alleged loss, theft or
destruction of such certificate) to the Corporation at the place designated in such notice. If so required by the Corporation, certificates surrendered for conversion shall be endorsed or accompanied by written instrument or instruments of transfer,
in form satisfactory to the Corporation, duly executed by the registered holder or by his, her or its attorney duly authorized in writing. All rights with respect to the Series D Preferred Stock converted pursuant to Subsection 5.1.2,
including the rights, if any, to receive notices and vote (other than as a holder of Common Stock), will terminate at the Series D Mandatory Conversion Time (notwithstanding the failure of the holder or holders thereof to surrender the certificates
at or prior to such time), except only the rights of the holders thereof, upon surrender of their certificate or certificates (or lost certificate affidavit and agreement) therefor, to receive the items provided for in the next sentence of this
Subsection 5.2.2. As soon as practicable after the Series D Mandatory Conversion Time and the surrender of the certificate or certificates (or lost certificate affidavit and agreement) for Series D Preferred Stock, the Corporation shall issue
and deliver to such holder, or to his, her or its nominees, a certificate or certificates for the number of full shares of Common Stock issuable on such conversion in accordance with the provisions hereof, together with cash as provided in
Subsection 4.2 in lieu of any fraction of a share of Common Stock otherwise issuable upon such conversion and the payment of any declared but unpaid dividends on the shares of Series D Preferred Stock converted. Such Series D Preferred Stock
shall be retired and cancelled and may not be reissued as shares of such series, and the Corporation may thereafter take such appropriate action (without the need for stockholder action) as may be necessary to reduce the authorized number of shares
of Series D Preferred Stock accordingly. 
 6. Redeemed or Otherwise Acquired Shares. Any shares of Preferred Stock that are redeemed
or otherwise acquired by the Corporation or any of its subsidiaries shall be automatically and immediately cancelled and retired and shall not be reissued, sold or transferred. Neither the Corporation nor any of its subsidiaries may exercise any
voting or other rights granted to the holders of Preferred Stock following redemption. 
 7. Waiver. Unless a different vote is
specified in the Certificate of Incorporation, any of the rights, powers, preferences and other terms of the ABC Preferred Stock set forth herein may be waived, either prospectively or retrospectively, on behalf of all holders of ABC Preferred Stock
by the affirmative written consent or vote of the holders of shares of ABC Preferred Stock representing at least sixty percent (60%) of the voting power of the shares of ABC Preferred Stock then outstanding. Unless a different vote is specified
in the Certificate of 

 
Incorporation, any of the rights, powers, preferences and other terms of any series of Preferred Stock set forth herein may be waived, either prospectively or retrospectively, on behalf of all
holders of such series of Preferred Stock by the affirmative written consent or vote of the holders of a majority of the shares of such series of Preferred Stock then outstanding. 

8. Notices. Any notice required or permitted by the provisions of this Article Fourth to be given to a holder of shares of Preferred
Stock shall be mailed, postage prepaid, to the post office address last shown on the records of the Corporation, or given by electronic communication in compliance with the provisions of the General Corporation Law, and shall be deemed sent upon
such mailing or electronic transmission. 
 FIFTH: Subject to any additional vote required by the Certificate of Incorporation or
Bylaws, in furtherance and not in limitation of the powers conferred by statute, the Board of Directors is expressly authorized to make, repeal, alter, amend and rescind any or all of the Bylaws of the Corporation. 

SIXTH: Subject to any additional vote required by the Certificate of Incorporation, the number of directors of the Corporation shall be
determined in the manner set forth in the Bylaws of the Corporation. 
 SEVENTH: Elections of directors need not be by written ballot
unless the Bylaws of the Corporation shall so provide. 
 EIGHTH: Meetings of stockholders may be held within or without the State of
Delaware, as the Bylaws of the Corporation may provide. The books of the Corporation may be kept outside the State of Delaware at such place or places as may be designated from time to time by the Board of Directors or in the Bylaws of the
Corporation. 
 NINTH: To the fullest extent permitted by law, a director of the Corporation shall not be personally liable to the
Corporation or its stockholders for monetary damages for breach of fiduciary duty as a director. If the General Corporation Law or any other law of the State of Delaware is amended after approval by the stockholders of this Article Ninth to
authorize corporate action further eliminating or limiting the personal liability of directors, then the liability of a director of the Corporation shall be eliminated or limited to the fullest extent permitted by the General Corporation Law as so
amended. 
 Any repeal or modification of the foregoing provisions of this Article Ninth by the stockholders of the Corporation shall not
adversely affect any right or protection of a director of the Corporation existing at the time of, or increase the liability of any director of the Corporation with respect to any acts or omissions of such director occurring prior to, such repeal or
modification. 
 TENTH: The Corporation renounces any interest or expectancy of the Corporation in, or in being offered an
opportunity to participate in, any Excluded Opportunity. An “Excluded Opportunity” is any matter, transaction or interest that is presented to, or acquired, created or developed by, or which otherwise comes into the possession of,
(i) any 

 
director of the Corporation who is not an employee of the Corporation or any of its subsidiaries, or (ii) any holder of Preferred Stock or any partner, member, director, stockholder,
employee or agent of any such holder, other than someone who is an employee of the Corporation or any of its subsidiaries (collectively, “Covered Persons”), unless such matter, transaction or interest is presented to, or acquired,
created or developed by, or otherwise comes into the possession of, a Covered Person expressly and solely in such Covered Person’s capacity as a director of the Corporation. 

ELEVENTH: The following indemnification provisions shall apply to the persons enumerated below. 

1. Right to Indemnification of Directors and Officers. The Corporation shall indemnify and hold harmless, to the fullest extent
permitted by applicable law as it presently exists or may hereafter be amended, any person (an “Indemnified Person”) who was or is made or is threatened to be made a party or is otherwise involved in any action, suit or proceeding,
whether civil, criminal, administrative or investigative (a “Proceeding”), by reason of the fact that such person, or a person for whom such person is the legal representative, is or was a director or officer of the Corporation or,
while a director or officer of the Corporation, is or was serving at the request of the Corporation as a director, officer, employee or agent of another corporation or of a partnership, joint venture, limited liability company, trust, enterprise or
nonprofit entity, including service with respect to employee benefit plans, against all liability and loss suffered and expenses (including attorneys’ fees) reasonably incurred by such Indemnified Person in such Proceeding. Notwithstanding the
preceding sentence, except as otherwise provided in Section 3 of this Article Eleventh, the Corporation shall be required to indemnify an Indemnified Person in connection with a Proceeding (or part thereof) commenced by such Indemnified Person
only if the commencement of such Proceeding (or part thereof) by the Indemnified Person was authorized in advance by the Board of Directors. 

2. Prepayment of Expenses of Directors and Officers. The Corporation shall pay the expenses (including attorneys’ fees) incurred
by an Indemnified Person in defending any Proceeding in advance of its final disposition, provided, however, that, to the extent required by law, such payment of expenses in advance of the final disposition of the Proceeding shall be
made only upon receipt of an undertaking by the Indemnified Person to repay all amounts advanced if it should be ultimately determined that the Indemnified Person is not entitled to be indemnified under this Article Eleventh or otherwise. 

3. Claims by Directors and Officers. If a claim for indemnification or advancement of expenses under this Article Eleventh is not paid
in full within 30 days after a written claim therefor by the Indemnified Person has been received by the Corporation, the Indemnified Person may file suit to recover the unpaid amount of such claim and, if successful in whole or in part, shall be
entitled to be paid the expense of prosecuting such claim. In any such action the Corporation shall have the burden of proving that the Indemnified Person is not entitled to the requested indemnification or advancement of expenses under applicable
law. 
 4. Indemnification of Employees and Agents. The Corporation may indemnify and advance expenses to any person who was or is
made or is threatened to be made or is otherwise 

 
involved in any Proceeding by reason of the fact that such person, or a person for whom such person is the legal representative, is or was an employee or agent of the Corporation or, while an
employee or agent of the Corporation, is or was serving at the request of the Corporation as a director, officer, employee or agent of another corporation or of a partnership, joint venture, limited liability company, trust, enterprise or nonprofit
entity, including service with respect to employee benefit plans, against all liability and loss suffered and expenses (including attorney’s fees) reasonably incurred by such person in connection with such Proceeding. The ultimate determination
of entitlement to indemnification of persons who are non-director or officer employees or agents shall be made in such manner as is determined by the Board of Directors in its sole discretion. Notwithstanding the foregoing sentence, the Corporation
shall not be required to indemnify a person in connection with a Proceeding initiated by such person if the Proceeding was not authorized in advance by the Board of Directors. 

5. Advancement of Expenses of Employees and Agents. The Corporation may pay the expenses (including attorney’s fees) incurred by
an employee or agent in defending any Proceeding in advance of its final disposition on such terms and conditions as may be determined by the Board of Directors. 

6. Non-Exclusivity of Rights. The rights conferred on any person by this Article Eleventh shall not be exclusive of any other rights
which such person may have or hereafter acquire under any statute, provision of the certificate of incorporation, these by-laws, agreement, vote of stockholders or disinterested directors or otherwise. 

7. Other Indemnification. The Corporation’s obligation, if any, to indemnify any person who was or is serving at its request as a
director, officer or employee of another Corporation, partnership, limited liability company, joint venture, trust, organization or other enterprise shall be reduced by any amount such person may collect as indemnification from such other
Corporation, partnership, limited liability company, joint venture, trust, organization or other enterprise. 
 8. Insurance. The
Board of Directors may, to the full extent permitted by applicable law as it presently exists, or may hereafter be amended from time to time, authorize an appropriate officer or officers to purchase and maintain at the Corporation’s expense
insurance: (a) to indemnify the Corporation for any obligation which it incurs as a result of the indemnification of directors, officers and employees under the provisions of this Article Eleventh; and (b) to indemnify or insure directors,
officers and employees against liability in instances in which they may not otherwise be indemnified by the Corporation under the provisions of this Article Eleventh. 

9. Amendment or Repeal. Any repeal or modification of the foregoing provisions of this Article Eleventh shall not adversely affect any
right or protection hereunder of any person in respect of any act or omission occurring prior to the time of such repeal or modification. The rights provided hereunder shall inure to the benefit of any Indemnified Person and such person’s
heirs, executors and administrators. 
 *    *    * 

 3. That the foregoing amendment and restatement was approved by the holders of the requisite
number of shares of this corporation in accordance with Section 228 of the General Corporation Law. 
 4. That this Amended and
Restated Certificate of Incorporation, which restates and integrates and further amends the provisions of this corporation’s Certificate of Incorporation, has been duly adopted in accordance with Sections 242 and 245 of the General Corporation
Law. 

 IN WITNESS WHEREOF, this Amended and Restated Certificate of Incorporation has been
executed by a duly authorized officer of this corporation on this      day of December, 2014. 
  

					
	By:		  

			Name:		Roger J. Pomerantz, M.D.
			Title:		President and Chief Executive Officer

 EXHIBIT B 

DISCLOSURE SCHEDULE 

 DISCLOSURE SCHEDULE 

This Disclosure Schedule is delivered by Seres Health, Inc. (the “Company”) pursuant to the Series D Preferred Stock Purchase
Agreement (the “Agreement”) of even date herewith by and among the Company and the Purchasers named in the Purchase Agreement. Capitalized terms used herein, which are not otherwise defined, shall have the respective meanings
ascribed to such terms in the Agreement. 
 Any disclosure hereunder shall not be deemed to be an admission or acknowledgment by the Company
that such information is material to, or outside the ordinary course of business of, the Company. Nothing herein constitutes an admission of liability or an admission against the Company’s interest. Nothing in the Disclosure Schedules is
intended to broaden the scope of any representation or warranty contained in the Agreement or to create any covenant. 
 References to any
document are to such document as amended as of the date of the Agreement, provided such amendment is properly noted in the reference to such document. All descriptions in the Disclosure Schedule of documents that have been previously delivered or
made available to the Purchasers or their counsel are qualified in their entirety by reference to the actual documents. 
 The section
numbers below correspond to the section numbers of the representations and warranties in the Agreement; provided, however, that any information disclosed herein under any section number shall be deemed to be disclosed and incorporated into any other
section number under the Agreement where such disclosure would be appropriate and such appropriateness is reasonably apparent from the face of such disclosure. 

Inclusion of any item in this Disclosure Schedule (1) does not represent a determination that such item is material or establish a
standard of materiality, (2) does not represent a determination that such item did not arise in the ordinary course of business and (3) does not represent a determination that the transactions contemplated by the Agreement require the
consent of third parties. 

 Schedule 2.2(c) 

Capitalization of the Company Immediately Following the Closing 

(i) Issued and Outstanding Common Stock. 
  

											
				
	Record Owner	 	Common Stock	 	  	Vesting Schedule	 	Repurchase Price	 
				
	 Flagship VentureLabs IV LLC
	 	 	3,055,556 shares	  	  	n/a	 	 	n/a	  
				
	 Nestlé Health Science US Holdings, Inc.
	 	 	1,944,444 shares	  	  	n/a	 	 	n/a	  
				
	 George Church
	 	 	100,000 shares	  	  	25% on the first anniversary of the grant date; thereafter, 6.25% quarterly, such that the shares will have vested in full on June 30, 2015	 	$	0.001 per share	  
				
	 James Collins
	 	 	50,000 shares	  	  	25% on the first anniversary of the grant date; thereafter, 6.25% quarterly, such that the shares will have vested in full on June 30, 2015	 	$	0.001 per share	  
				
	 Peter Hutt
	 	 	50,000 shares	  	  	25% on the first anniversary of the grant date; thereafter, 6.25% quarterly, such that the shares will have vested in full on June 30, 2015	 	$	0.001 per share	  
				
	 Kim Lewis
	 	 	100,000 shares	  	  	25% on the first anniversary of the grant date; thereafter, 6.25% quarterly, such that the shares will have vested in full on September 30, 2015	 	$	0.001 per share	  
				
	 David Relman
	 	 	100,000 shares	  	  	25% on the first anniversary of the grant date; thereafter, 6.25% quarterly, such that the shares will have vested in full on September 30, 2015	 	$	0.001 per share	  

											
				
	 Andrew Goodman
		 	10,000 shares	  		25% of the shares vested on January 7, 2013 and an additional 6.25% of the original number of shares vest in twelve equal quarterly installments commencing on April 7, 2013 and continuing in like fashion thereafter
until all shares have vested		$	0.001 per share	  
				
	 John Aunins
		 	50,000 shares	  		Shares are fully vested		$	0.001 per share	  
				
	 Avak Kahvejian
		 	150,000 shares	  		16.67% of the shares vested on June 16, 2012 and an additional 16.67% of the original number of shares vest in quarterly installments thereafter until fully vested		$	0.001 per share	  
				
	 Geoffrey von Maltzahn
		 	300,000 shares	  		25% of the shares vested on March 12, 2012 and an additional 6.25% of the original number of shares vest at the end of each three month period such that the shares will have vested in full on March 12, 2015		$	0.001 per share	  
				
	 David Berry
		 	700,000 shares	  		50% of the shares vested on January 28, 2012 and an additional 6.25% of the original number of shares vest in quarterly installments commencing on April 28, 2012 until fully vested		$	0.001 per share	  
				
	 Frank Bobe
		 	245,000 shares	  		n/a				
				
	 Michael Briskin
		 	6,563 shares	  		n/a				
				
	 Matthew Henn
		 	15,000 shares	  		n/a				
				
	 Anthony D’Onofrio
		 	3,750 shares	  		n/a				

									
				
	 Toshiro Ohsumi
		 	6,562 shares	  		n/a		
				
	 Allison DiGaetano
		 	1,375 shares	  		n/a		
				
	 Han Zhang
		 	1,000 shares	  		n/a		
				
	 Alexander Belanger
		 	1,500 shares	  		n/a		
				
	 Total
		 	6,890,750 shares	  				

 (ii) Granted Stock Options. 
  

																															
	 Optionee
	 	Date of
Grant	 	Type of
Grant	 	Stock
Options	 	 	Price/
CS Share	 	 	Vesting
Commencement
Date	 	Date of
Exercise	 	Options
Exercised	 	 	Options
Canceled	 	 	Options
Outstanding	 	 	Vesting
Schedule
	EMPLOYEES:	 		 		 				 				 		 		 				 				 				 	
	 Rebecca McNeill
	 	08/22/12	 	ISO	 	 	55,000	  	 	$	0.10	  	 	07/16/12	 		 				 	 	55,000	  	 	 	0	  	 	1
	 Matthew Henn
	 	08/22/12	 	ISO	 	 	30,000	  	 	$	0.10	  	 	06/01/12	 	08/12/14	 	 	15,000	  	 				 	 	15,000	  	 	1
	 Mary-Jane McKenzie
	 	08/22/12	 	ISO	 	 	17,500	  	 	$	0.10	  	 	06/14/12	 		 				 				 	 	17,500	  	 	1
	 Anthony D’Onofrio
	 	08/22/12	 	ISO	 	 	7,500	  	 	$	0.10	  	 	05/21/12	 	07/28/14	 	 	3,750	  	 	 	3,750	  	 	 	0	  	 	1
	 Kevin Litcofsky
	 	09/27/12	 	ISO	 	 	7,500	  	 	$	0.10	  	 	08/31/12	 		 				 				 	 	7,500	  	 	1
	 Tohiro Ohsumi
	 	09/27/12	 	ISO	 	 	15,000	  	 	$	0.10	  	 	09/10/12	 	07/31/14	 	 	6,562	  	 				 	 	8,438	  	 	1
	 Jonathan Winkler
	 	09/27/12	 	ISO	 	 	7,500	  	 	$	0.10	  	 	09/24/12	 		 				 				 	 	7,500	  	 	1
	 Alexander Belanger
	 	05/17/13	 	ISO	 	 	3,000	  	 	$	0.48	  	 	06/26/12	 	08/15/14	 	 	1,500	  	 	 	1,500	  	 	 	0	  	 	1
	 Allison DiGaetano
	 	05/17/13	 	ISO	 	 	2,000	  	 	$	0.48	  	 	10/22/12	 	09/02/14	 	 	1,375	  	 				 	 	625	  	 	1
	 David Cook
	 	05/17/13	 	ISO	 	 	327,500	  	 	$	0.48	  	 	10/24/12	 		 				 				 	 	327,500	  	 	1
	 John Aunins
	 	05/17/13	 	ISO	 	 	200,000	  	 	$	0.48	  	 	12/01/12	 		 				 				 	 	200,000	  	 	1
	 Marin Vulic
	 	05/17/13	 	ISO	 	 	7,500	  	 	$	0.48	  	 	03/07/13	 		 				 				 	 	7,500	  	 	1
	 Greg McKenzie
	 	11/06/13	 	ISO	 	 	17,500	  	 	$	0.48	  	 	09/19/13	 		 				 				 	 	17,500	  	 	1
	 Han (Angela) Zhang
	 	11/06/13	 	ISO	 	 	4,000	  	 	$	0.48	  	 	08/21/13	 	08/22/14	 	 	1,000	  	 	 	3,000	  	 	 	0	  	 	1
	 Christopher McChalicher
	 	11/06/13	 	ISO	 	 	7,500	  	 	$	0.48	  	 	09/09/13	 		 				 				 	 	7,500	  	 	1
	 Matthew Henn
	 	08/07/14	 	ISO	 	 	30,000	  	 	$	0.71	  	 	04/30/14	 		 				 				 	 	30,000	  	 	1
	 Matthew Henn
	 	08/07/14	 	ISO	 	 	30,000	  	 	$	0.71	  	 	06/18/14	 		 				 				 	 	30,000	  	 	1
	 Matthew Henn
	 	08/07/14	 	NQO	 	 	40,000	  	 	$	0.71	  	 		 		 				 				 	 	40,000	  	 	5
	 Roger Pomerantz
	 	08/07/14	 	ISO	 	 	321,931	  	 	$	0.71	  	 	06/01/14	 		 				 				 	 	321,931	  	 	1
	 Roger Pomerantz
	 	08/07/14	 	NQO	 	 	1,353,820	  	 	$	0.71	  	 	06/01/14	 		 				 				 	 	1,353,820	  	 	1
	 Sanabel Almomani
	 	08/21/14	 	ISO	 	 	3,000	  	 	$	0.71	  	 	06/26/14	 		 				 				 	 	3,000	  	 	1
	 David Stancyk
	 	08/21/14	 	ISO	 	 	3,000	  	 	$	0.71	  	 	06/30/14	 		 				 				 	 	3,000	  	 	1
	 Jose Manuel Otero
	 	08/21/14	 	ISO	 	 	30,000	  	 	$	0.71	  	 	08/04/14	 		 				 				 	 	30,000	  	 	1
	 Jose Manuel Otero
	 	08/21/14	 	NQO	 	 	20,000	  	 	$	0.71	  	 		 		 				 				 	 	20,000	  	 	5
	 Carol Lewis Cullinan
	 	10/06/14	 	ISO	 	 	20,000	  	 	$	3.14	  	 	09/15/14	 		 				 				 	 	20,000	  	 	1
	 Sarah Garant
	 	10/06/14	 	ISO	 	 	7,500	  	 	$	3.14	  	 	09/15/14	 		 				 				 	 	7,500	  	 	1
	 Stephanie Woodall
	 	10/06/14	 	ISO	 	 	4,000	  	 	$	3.14	  	 	09/22/14	 		 				 	 	4,000	  	 	 	0	  	 	1
	 Lisa Geller
	 	10/06/14	 	ISO	 	 	25,000	  	 	$	3.14	  	 	09/29/14	 		 				 				 	 	25,000	  	 	1
	 Eric D. Shaff
	 	12/09/14	 	ISO	 	 	262,692	  	 	$	7.79	  	 	11/17/14	 		 				 				 	 	262,692	  	 	1
	 James Weston
	 	12/09/14	 	ISO	 	 	50,000	  	 	$	7.79	  	 	12/08/14	 		 				 				 	 	50,000	  	 	1
	 Julie Button
	 	12/09/14	 	ISO	 	 	7,500	  	 	$	7.79	  	 	11/17/14	 		 				 				 	 	7,500	  	 	1
											
	NON EMPLOYEES:	 		 		 				 				 		 		 				 				 				 	
	 Sherwood Gorbach
	 	08/22/12	 	NSO	 	 	50,000	  	 	$	0.10	  	 	09/01/12	 		 				 				 	 	50,000	  	 	2
	 Eric Collard
	 	08/22/12	 	NSO	 	 	36,500	  	 	$	0.10	  	 	08/27/13	 		 				 				 	 	36,500	  	 	3
	 Peter Turnbaugh
	 	08/22/12	 	NSO	 	 	30,000	  	 	$	0.10	  	 	06/01/12	 		 				 				 	 	30,000	  	 	1
	 Charles L. Cooney
	 	08/22/12	 	NSO	 	 	30,000	  	 	$	0.10	  	 	06/01/12	 		 				 				 	 	30,000	  	 	1
	 Ed deLong
	 	08/22/12	 	NSO	 	 	15,000	  	 	$	0.10	  	 	10/31/11	 		 				 				 	 	15,000	  	 	1
	 Patrick Cahil
	 	08/22/12	 	NSO	 	 	5,000	  	 	$	0.10	  	 	08/25/12	 		 				 				 	 	5,000	  	 	1
	 Georgia Giannoukos
	 	08/22/12	 	NSO	 	 	5,000	  	 	$	0.10	  	 	08/25/12	 		 				 				 	 	5,000	  	 	1
	 Mike Cerruti
	 	09/27/12	 	NSO	 	 	6,336	  	 	$	0.10	  	 	09/27/12	 		 				 				 	 	6,336	  	 	4
	 Werner Cautreels
	 	05/17/13	 	NSO	 	 	100,000	  	 	$	0.48	  	 	03/01/13	 		 				 				 	 	100,000	  	 	1
	 Curtis Huttenhower
	 	05/17/13	 	NSO	 	 	30,000	  	 	$	0.48	  	 	02/26/13	 		 				 				 	 	30,000	  	 	1
	 Max Nieuwdorp
	 	05/17/13	 	NSO	 	 	30,000	  	 	$	0.48	  	 	04/08/13	 		 				 				 	 	30,000	  	 	1
	 Roger Pomerantz
	 	11/06/13	 	NSO	 	 	220,000	  	 	$	0.48	  	 	09/09/13	 		 				 				 	 	220,000	  	 	1
	 Peter Barton Hutt
	 	11/06/13	 	NSO	 	 	50,000	  	 	$	0.48	  	 	05/17/13	 		 				 				 	 	50,000	  	 	1
	 Beth Bronstein
	 	08/21/14	 	NSO	 	 	3,500	  	 	$	0.71	  	 	07/21/14	 		 				 	 	3,500	  	 	 	0	  	 	1
	 Richard Kinder
	 	10/06/14	 	NSO	 	 	75,000	  	 	$	3.14	  	 	10/06/14	 		 				 				 	 	75,000	  	 	1
	 Lorence Kim
	 	10/06/14	 	NSO	 	 	75,000	  	 	$	3.14	  	 	10/06/14	 		 				 				 	 	75,000	  	 	1
		 		 		 	  
	  
	 	 				 		 		 	  
	  
	 	 	  
	  
	 	 	  
	  
	 	 	
	 Total:
						 	3,678,779	  										 	29,187	  		 	70,750	  		 	3,578,842	  		
		 		 		 	  
	  
	 	 				 		 		 	  
	  
	 	 	  
	  
	 	 	  
	  
	 	 	

 Vesting Schedule: 
  

	#1)	25% of the total number of shares on the first anniversary of the Vesting Start Date noted in the following table and as to an additional 6.25% of the total number of shares on the last day of each calendar quarter
thereafter 

	#2)	Stock option to vest (subject to continued service with the Corporation) as to 6.25% of the total number of shares on September 1, 2012 and as to an additional 6.25% of the total number of shares on the last day
of each calendar quarter thereafter 

	#3)	Stock option to vest (subject to continued service with the Corporation) as to 25% of the total number of shares on February 27, 2013 and as to an additional 4.167% of the total number of shares on the last day
of each month 

	#4)	Options shall become immediately fully vested on the Grant Date. 

	#5)	Performance based 

 (iii) Shares of Common Stock reserved for Future Award Grants under the Stock Plan: 

0 shares 
 (iv) Each series of Preferred Stock. 

 

					
	 8,230,997 shares of Series A Preferred Stock:
				
	 Flagship Ventures Fund IV, L.P.
		 	6,105,362	  
	 Flagship Ventures Fund IV-Rx, L.P.
		 	1,526,338	  
	 Flagship Ventures Fund 2007, L.P.
		 	599,297	  
		
	 2,247,192 shares of Series A-2 Preferred Stock:
				
	 Flagship Ventures Fund IV, L.P.
		 	898,877	  
	 Flagship Ventures Fund IV-Rx, L.P.
		 	224,719	  
	 Enso Ventures 2 Limited
		 	1,123,596	  
		
	 4,831,359 shares of Series B Preferred Stock:
				
	 Flagship Ventures Fund IV, L.P.
		 	1,818,181	  
	 Flagship Ventures Fund IV-Rx, L.P.
		 	454,546	  
	 Enso Ventures 2 Limited
		 	681,818	  
	 Mayo Clinic
		 	795,454	  
	 Alexandria Equities, LLC
		 	909,090	  
	 Roger Pomerantz
		 	22,727	  
	 Favreau 2008 Trust, dtd 4-10-2008
		 	45,454	  
	 John Aunins
		 	34,090	  
	 David Cook
		 	45,454	  
	 Matthew Henn
		 	24,545	  

  

					
	 3,946,328 shares of Series C Preferred Stock:
				
	 Fidelity Select Portfolios: Biotechnology Portfolio
		 	1,292,035	  
	 Fidelity Advisor Series VII: Fidelity Advisor Biotechnology Fund
		 	352,270	  
	 Fidelity Growth Company Commingled Pool
		 	107,186	  
	 Fidelity Mt. Vernon Street Trust: Fidelity Series Growth Company Fund
		 	142,139	  
	 Fidelity Mt. Vernon Street Trust: Fidelity Growth Company Fund
		 	572,827	  
	 Rock Springs Capital Master Fund LP
		 	82,215	  
	 BlackRock Health Sciences Trust
		 	20,710	  
	 BlackRock Health Sciences Opportunities
				
	 Portfolio, a series of BlackRock Funds
		 	301,970	  
	 BlackRock Health Sciences Master Unit Trust
		 	6,180	  
	 Leerink Holdings LLC
		 	41,107	  
	 Leerink Swann Co-Investment Fund, LLC
		 	41,108	  
	 T. Rowe Price Health Sciences Fund, Inc.
		 	329,922	  
	 TD Mutual Funds - TD Health Sciences Fund
		 	16,282	  
	 VALIC Company I - Health Sciences Fund
		 	20,906	  
	 T. Rowe Price Health Sciences Portfolio
		 	15,843	  
	 John Hancock Variable Insurance Trust - Health Sciences Trust
		 	9,734	  

					
	 John Hancock Funds II - Health Sciences Fund
		 	18,389	  
	 Sofinnova Venture Partners IX, L.P.
		 	82,215	  
	 RA Capital Healthcare Fund, LP
		 	246,645	  
	 OrbiMed Private Investments V, LP
		 	246,645	  
		
	 2,222,222 shares of Series D Preferred Stock:
				
	 Nestlé Health Science US Holdings, Inc.
		 	2,222,222	  
		
	 1,388,889 shares of Series D-1 Preferred Stock:
				
	 Nestlé Health Science US Holdings, Inc.
		 	1,388,889	  

 (v) Warrants or Stock Purchase Rights. 
  

	 	•	 	Reference is made to the Assignment, Assumption and Waiver Agreement by and among Essentient, Inc., the Company and Flagship Ventures Fund 2007 and the obligations and liabilities with respect to the convertible
promissory notes assigned under the agreement (the “Assignment, Assumption and Waiver Agreement”). Such promissory notes have been fully converted into shares of Series A Preferred Stock. 

 

	 	•	 	Pursuant to a Research and Option Agreement, dated on or about the date hereof, by and between the Company and Mayo Foundation for Medical Education and Research (the “Mayo Research and Option
Agreement”), the Company issued Mayo Foundation for Medical Education and Research a funding warrant to purchase up to an aggregate of 454,545 shares of Common Stock based on the terms and conditions set forth in the Research and Option
Agreement. The Company also issued Mayo Foundation for Medical Education and Research an incentive warrant to purchase up to an aggregate of 284,090 shares of Common Stock upon the achievement of certain milestones set forth in such warrant. No
shares of Common Stock are issuable pursuant to the terms of such warrant as of the date hereof. 

  

	 	•	 	Pursuant to a Participation Rights Agreement entered into by and between the Company and Alexandria Equities, LLC (“Alexandria”), an affiliate of the Company’s landlord, Alexandria purchased
$250,000 of the shares issued in the Company’s Series B Preferred Stock financing. Alexandria has no further rights to acquire shares of the Company pursuant to the Participation Rights Agreement. 

 

	 	•	 	Pursuant to that certain offer letter from the Company to John Aunins, dated as of October 18, 2012 (the “Aunins Offer Letter”), Mr. Aunins invested $50,000 in the Company’s Series B
Preferred Stock financing. Mr. Aunins has no further rights to participate in the Company’s future equity financings pursuant to the Aunins Offer Letter. 

 

	 	•	 	Pursuant to a Loan and Security Agreement entered into by and between the Company and Comerica Bank in September 2013 (the “Comerica Loan Agreement”), the Company issued Comerica Bank a Warrant to
purchase up to 92,127 shares of Series A-2 Preferred Stock at a purchase price of $1.78 per share. 

 Schedule 2.2(d) 

Acceleration 
 Reference is made to that
certain offer letter from the Company to David Cook, dated as of October 4, 2012 (the “Cook Offer Letter”). 
 Reference is made to
that certain offer letter from the Company to Roger Pomerantz, dated as of April 23, 2014 (the “Pomerantz Offer Letter”). 
 Reference
is made to that certain offer letter from the Company to Eric Shaff, dated as of October 28, 2014 (the “Shaff Offer Letter”). 

Reference is made to the Aunins Offer Letter. 

 Schedule 2.3 

Subsidiaries 
 The Company
is in the process of incorporating a Massachusetts securities corporation, which will be a wholly owned subsidiary of the Company. 

 Schedule 2.8 

Company Intellectual Property 
 (a)(i)

 Patents/Applications 
  

									
	 SERES HEALTH REF.
	 	 Country
	  	 Application
Number/Patent
Number
	  	 FILING DATE
	  	 TITLE

					
	SER0001PR1*	 	US	  	61442586	  	14-Feb-11	  	Compositions and Methods of Treatment of Gastro-Intestinal Disorders Using Microbial Ecosystems
					
	SER0001PR2*	 	US	  	61606192	  	2-Mar-12	  	Compositions and Methods of Treatment of Gastro-Intestinal Disorders Using Microbial Ecosystems
					
	SER0002PR1*	 	US	  	61606203	  	2-Mar-12	  	Compositions and Methods of Treatment of Gastro-Intestinal Disorders Using Extracted Microbial Communities
					
	SER0003/0004PR1*	 	US	  	61606221	  	2-Mar-12	  	Compositions and Methods of Treatment of Gastro-Intestinal Disorders Using Microbial Ecosystems
					
	SER0005PR1*	 	US	  	61606224	  	2-Mar-12	  	Microbial Ecosystems Compositions and Methods for the Treatment of Diseases and Disorders
					
	SER0006PR1@	 	US	  	61729518	  	23-Nov-12	  	Novel Combinations of Microbes
					
	SER0006PR2@	 	US	  	61729519	  	23-Nov-12	  	Novel Combinations of Microbes

									
					
	SER0006PR3@		US		61729520		23-Nov-12		Novel Combinations of Microbes
					
	SER0006PR4@		US		61729521		23-Nov-12		Novel Combinations of Microbes
					
	SER0006PR5@		US		61729522		23-Nov-12		Novel Combinations of Microbes
					
	SER0006PR6@		US		61729524		23-Nov-12		Novel Combinations of Microbes
					
	SER0006PR7@		US		61729515		23-Nov-12		Novel Combinations of Microbes
					
	SER0006PR8@		US		61729517		23-Nov-12		Novel Combinations of Microbes
					
	SER0006PR9@		US		61729525		23-Nov-12		Novel Combinations of Microbes
					
	SER0006PR10@		US		61729526		23-Nov-12		Novel Combinations of Microbes
					
	SER0006PR11@		US		61729527		23-Nov-12		Novel Combinations of Microbes
					
	SER0006WO1		PCT		PCTUS2013071758		25-Nov-13		Synergistic Bacterial Compositions and Methods of Production and Use Thereof
					
	SER0006US1 i		US		14091201/8906668		26-Nov-13		Synergistic Bacterial Compositions and Methods of Production and Use Thereof
					
	SER0006US2^		US		14221190		20-Mar-14		Synergistic Bacterial Compositions and Methods of Production and Use Thereof
					
	SER0007PR1@		US		61760584		4-Feb-13		Method of Populating a Gastrointestinal Tract
					
	SER0007WO1		PCT		PCTUS2014014738		4-Feb-14		Method of Populating a Gastrointestinal Tract

									
					
	SER0008PR1@		US		61760585		4-Feb-13		Compositions and Methods
					
	SER0008WO1		PCT		PCTUS2014014747		4-Feb-14		Compositions and Methods
					
	SER0009PR1@		US		61781854		14-Mar-13		Methods for Pathogen Detection and Enrichment from Materials and Compositions
					
	SER0009WO1		PCT		PCTUS2014029539		14-Mar-14		Methods for Pathogen Detection and Enrichment from Materials and Compositions
					
	SER0010PR1@		US		61760574		4-Feb-13		Compositions and Methods for Inhibition of Pathogenic Bacterial Growth
					
	SER0010WO1		PCT		PCTUS2014014744		4-Feb-14		Compositions and Methods for Inhibition of Pathogenic Bacterial Growth
					
	SER0011PR1@		US		61760606		4-Feb-13		Compositions and Methods
					
	SER0011PR2@		US		61926918		13-Jan-14		Compositions and Methods
					
	SER0011WO1		PCT		PCTUS2014014745		4-Feb-14		Compositions and Methods
					
	SER0011US1^		US		14197044		4-Mar-14		Compositions and Methods
					
	SER011US2		US		14313828		24-Jun-14		Compositions and Methods
					
	SER0012PR2@		US		61798666		15-Mar-13		Network-Based Microbial Compositions and Methods
					
	SER0012WO1		PCT		PCTUS2014030817		17-Mar-14		Network-Based Microbial Compositions and Methods

									
					
	SER0012PR3		US		61954532		17-Mar-14		Network-Based Microbial Compositions and Methods
					
	SER0013PR2@		US		61798606		15-Mar-13		Microbial Compositions and Methods
					
	SER0014PR1*		US		61856371		19-Jul-13		Microbial Compositions and Methods
					
	SER0014PR2		US		62026674		20-Jul-14		Microbial Compositions and Methods
					
	SER0015PR1@		US		61908698		25-Nov-13		Synergistic Bacterial Compositions and Methods of Production and Use Thereof
					
	SER0016PR1*		US		61908675		25-Nov-13		Bacterial Compositions and Methods of Production and Use Thereof
					
	SER0017PR1@		US		61908702		25-Nov-13		Defined Bacterial Compositions and Methods of Production and Use Thereof
					
	SER0018PR1*		US		61908696		25-Nov-13		Bacterial Compositions and Methods of Use Thereof for Treatment of Autism
					
	SER0019PR1@		US		61916761		16-Dec-13		Bacterial Compositions and Methods of Use Thereof for Treatment of Immune System Disorders
					
	SER0019WO1		PCT				16-Dec-14		Bacterial Compositions and Methods of Use Thereof for Treatment of Immune System Disorders
					
	SER0023PR1		US		61926920		13-Jan-14		Infectious Disease

									
					
	SER0024PR1@	 	US	  	62004187	  	28-May-14	  	Synergistic Bacterial Compositions and Methods of Production and Use Thereof
					
	SER0024WO1	 	PCT	  		  	25-Nov-14	  	Synergistic Bacterial Compositions and Methods of Production and Use Thereof
					
	SER0026PR1	 	US	  	62047306	  	8-Sept-14	  	Infectious Disease

  

	*	Abandoned 

	@ 	Converted 

	^	Allowed 

	i 	Issued Patent 

 Trademarks (Live) 

 

													
	 Mark
	 	 Appl. No
	 	 Appl. Date
	 	Reg No	 	Reg Date	 	 Country
	 	Class(es)
	 ECOSPOR
	 	86435951	 	27-Oct-14	 		 		 	United States	 	5
	 ECOSPOR
	 	86469811	 	3-DEC-14	 		 		 	United States	 	5 and 42
	 SERES HEALTH
	 	85/755,193	 	16-Oct-12	 		 		 	United States	 	5, 32, 42, and 44
	 SERES
	 	85/651,848	 	14-Jun-12	 		 		 	United States	 	5 and 42
	 SERES LOGO (sphere comprising shapes resembling shaded figure eights)
	 	85/661,601	 	26-Jun-12	 		 		 	United States	 	5 and 42
	 SERES LOGO (sphere comprising shapes resembling shaded figure eights)
	 	85/981,154	 	26-Jun-12	 	4,508,229	 	1-Apr-2014	 	United States	 	5

													
	 ECOBIOTIC
		85/674,109		11-Jul-12						United States		5 and 42
	 ECOBIOTIC
		85/980,662		11-Jul-12		4,464,145		7-Jan-14		United States		5
	 ECOBIOTIC
		011442456		20-Dec-12		011442456		20-May-13		Community Trademark (European Union)		5 and 42
	 MICROBIOME THERAPEUTICS
		86/033,983		9-Aug-13						United States		5
	 MICROBIOME THERAPEUTICS
		86/975,001		9-Aug-13						United States		5
	 LIFE SAVING MICROBIOME TECHNOLOGIES
		86/469,813		3-Dec-14						United States		5
	 SERES THERAPEUTICS
		86/481,483		16-DEC-14						United States		5

 (a)(ii) - Product Candidates 

SER-109 
 (b) 

The following current Key Employees have excluded works or inventions from his or her assignment of inventions pursuant to such Key Employee’s
Confidential Information Agreement: 
  

	 	•	 	Toshiro Ohsumi: 

 MolBioLib (sourceforge.net/projects/molbiolib) 

 

	 	•	 	Matthew Henn: 

 Algorithms: V-Phaser, V-Profiler, RC454, AV454, VICUNA, ViralView (a.k.a. Viral
Vizualizer & V-Visualizer), V-Haplotype 
  

	 	•	 	David Cook: 

 US Patents: 6514987, 6143490, 7691393, 6270952, 7695725, 6410219, 7833775,
6709810, 7842289, 7927606, 5559250, 5691132, 7293985, 6177441 

 None of the excluded works or inventions of a proprietary nature listed above is expected to be used or useful or
requires a license in the Company’s business as the same is conducted or currently planned to be conducted. 
 (d) - Complaints,
Claims, Notices or Threats of Infringement 
 None. 

(e) - Domain Names 

seresbiosciences.com 
 sereshealth.com 

serestherapeutics.com 
 serestx.com 

seresdx.com 
 seresbio.com 

eco-spor.com 
 ecospor.net 

ecospor.info 
 ecospor.org 

ecospor.com 
 seres-therapeutics.com 

serestheraputics.com 
 serestherapuetics.com 

serestherapeutic.com 
 (f) - Company Intellectual
Property Owned by a Third Party 
 None. 

 Schedule 2.10 

Agreements; Actions 
 Reference is made to
the Assignment, Assumption and Waiver Agreement. 
 Agreement by and between the Company and Transpharm (the “Transpharm Agreement”). 

The Company paid Flagship Ventures $157,000 in 2013 for its services, and it anticipates that it will pay Flagship approximately $277,307 in 2014. 

Reference is made to the Lease Agreement dated June 29, 2012 between the Company and ARE-MA REGION NO.21, LLC, as amended. 

Agreement by and between the Company and Olympus 
 Agreement by
and between the Company and Northeastern University 
 Agreement by and between the Company and The General Hospital Corporation D/B/A Massachusetts General
Hospital 
 Agreement by and between the Company and Mayo Clinic 

Agreement by and between the Company and Emory 
 Agreement by
and between the Company and Lifespan 
 Agreement by and between the Company and Metanome 

 Agreement by and between the Company and University of North Texas Science Center 

Agreement by and between the Company and Danforth Advisors LLC 

Agreement by and between the Company and The Miriam Hospital 

Agreement by and between the Company and Halloran Consulting 

Agreement by and between the Company and Assuerus Strategic Consulting 

Agreement by and between the Company and Diane Marsolini Clinical Research Consultant 

Agreement by and between the Company and Korn Ferry International 

Agreement by and between the Company and Kesic Cervino 

Agreement by and between the Company and The Frankel Group 

Mayo Research and Option Agreement 
 Letter Agreement by and
between the Company and INC Research, LLC 
 Agreement by and between the Company and Genlbet Biopharmaceuticals S.A.

 Agreement by and between the Company and BioReliance Corporation 

Agreement by and between the Company and Clinical Consortium, Inc. 

Agreement by and between the Company and Omega Pharm Services 

Agreement by and between the Company and Integrium, LLC, as amended 

 Schedule 2.12 

Rights of Registration and Voting Rights 

Reference is made to the Stock Purchase Agreement dated December 19, 2014, by and between Flagship VentureLabs IV LLC and Nestlé Health Science US
Holdings, Inc. 

 Schedule 2.13 

Property 
 Pursuant to the Comerica Loan
Agreement, Comerica Bank has a first priority security interest on all assets of the Company, including but not limited to all present and future accounts, accounts receivable and the rights to payment thereof, inventory, contract rights, chattel
paper, unencumbered equipment, general intangibles (excluding intellectual property), and the rights to proceeds from the sale of intellectual property. Comerica Bank and the Company also agreed to a negative pledge with respect to the
Company’s intellectual property and further agreed that the Company would not pledge or provide a negative pledge to any third party with respect to its intellectual property during the term of the Comerica credit facility. 

 Schedule 2.15 

Changes 
  

	(f)	

 The following officers of the Company have the target annual cash bonus amounts (expressed as a percentage of
the officer’s annual base salary) set forth opposite the officer’s name in respect of performance during the Company’s year ended December 31, 2014: 
  

					
	 Name
	  	Target Bonus (%)	 
	 David Cook
	  	 	30	% 
	 John Aunins
	  	 	25	% 
	 Matthew Henn
	  	 	25	% 

 Effective December 15, 2014, the annual base salary of Matthew Henn was increased to $185,000. 

 Schedule 2.16(a) 

Employee Matters 
 (a) 

The Company currently employs 24 full time employees, two part-time employees and engages 17 outside consultants or independent contractors. 

 

											
	 Name
	  	Salary	 	  	 Bonus
	  	 Severance Obligation
	  	 Deferred
Compensation

	 Roger Pomerantz
	  	$	425,000	  	  	 Targeted at 50% of annual salary
	  	 Six months compensation if within six months of a Sales Event (i) terminated without Cause or (ii) resigns for Good Reason and
complies with a separation agreement. (Capitalized terms are defined within the Pomerantz Offer Letter.)
	  	 None

	 Eric Shaff
	  	$	300,000	  	  	 Targeted at 30% of annual salary
	  	 Six months compensation if within six months of a Sales Event (i) terminated without Cause or (ii) resigns for Good Reason and
complies with a separation agreement. (Capitalized terms are defined within the Shaff Offer Letter.)
	  	 None

	 John Aunins
	  	$	260,000	  	  	 Targeted at 25% of annual salary
	  	 Three months compensation if (i) terminated without Cause or (ii)(a) terminated without Cause or (b) terminates for Good Reason, in
case of (ii)(a) (Capitalized terms are defined within the Aunins Offer Letter.)
	  	 None

	 David Cook
	  	$	300,000	  	  	 Targeted at 30% of annual salary
	  	 Four months compensation if (i) terminated without Cause or (ii)(a) terminated without Cause or (b) terminates for Good Reason, in
case of (ii)(a) (Capitalized terms are defined within the Cook Offer Letter.)
	  	 None

	 Carol Lewis-Cullinan
	  	$	225,000	  	  	 $10,000 signing bonus and performance bonuses upon the achievement of certain milestones
	  	 None
	  	 None

											
	 Lisa N. Geller
		$	220,000	  		 None
		 None
		 None

	 Jose Manual Otero
		$	185,000	  		 $30,000 signing bonus
		 None
		 None

	 Matthew Henn
		$	185,000	  		 Targeted at 25% of annual salary
		 None
		 None

	 Mary Jane Lombardo
		$	115,000	  		 None
		 None
		 None

	 Toshiro Ohsumi
		$	100,000	  		 None
		 None
		 None

	 Transpharm
		$	1,260,437	  		 None
		 None
		 None

	 Danforth Advisors LLC
		$	200,840	  		 None
		 None
		 None

	 Diane Marsolini
		$	107,026	  		 None
		 None
		 None

	 Gregory McKenzie
		$	120,000	  		 None
		 None
		 None

	 Sarah M. Garant
		$	100,000	  		 None
		 None
		 None

	 Christopher McChalicher
		$	100,000	  		 None
		 None
		 None

	 Assuerus Strategic Consulting
		$	134,680	  		 None
		 None
		 None

	 Stratacuity
		$	100,000	  		 None
		 None
		 None

 The Company paid Flagship Ventures $157,000 in 2013 for its services, and it anticipates that it will pay Flagship
approximately $277,307 in 2014. 
 (d) 
 Reference is
made to the Aunins Offer Letter, the Cook Offer Letter, the Pomerantz Offer Letter and the Shaff Offer. 

 (g) 
 The
Company provides benefits to its employees under the benefits plan of Flagship Ventures Management, Inc., which is controlled by Flagship Ventures. 
 In
addition, the Company sponsors a 401(k) plan where employees are able to defer their salary to the IRS set limits. No Company match is provided. 

 Schedule 2.17 

Tax Returns and Payments 

In 2013, certain miscellaneous employee reimbursements related to commuting expenses incurred by John Aunins may have be improperly reported
for federal and state income tax purposes. The total amount of reimbursements at issue is less than $10,000. 

 Schedule 2.19 

Employee Agreements 
 See
Schedule 2.8(b). 

 Schedule 2.21 

Clinical Trials 
 The
Company is currently conducting a single arm study entitled “Modified Fecal Microbiota Transplant” which is testing the oral delivery of the company’s lead Ecobiotic® microbial therapeutic, SER-109 for the prevention of
Clostridium difficile recurrence in multiply recurrent patients. 
 The Company filed its investigational new drug application, or IND, with
the Federal Drug Administration on December 10, 2014 to initiate its Phase 3 clinical trial for SER-109. 

 EXHIBIT C 

FORM OF INVESTORS’ RIGHTS AGREEMENT 

 AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT 

THIS AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT is made as of the 19th day of December, 2014, by and among Seres Health, Inc., a
Delaware corporation (the “Company”), and each of the investors listed on Schedule A hereto, each of which is referred to in this Agreement as an “Investor.” 

RECITALS 
 WHEREAS,
certain of the Investors (the “Existing Investors”) possess registration rights, information rights, rights of first offer, and other rights pursuant to an Amended and Restated Investors’ Rights Agreement dated as of
November 24, 2014, between the Company and such Investors (as amended, the “Prior Agreement”);  

WHEREAS, the Existing Investors desire to amend and restate the Prior Agreement in its entirety and to accept the rights created
pursuant to this Agreement in lieu of the rights granted to them under the Prior Agreement; and 
 WHEREAS, one of the
Investors is a party to that certain Series D Preferred Stock Purchase Agreement of even date herewith between the Company and such Investor (the “Purchase Agreement”), under which certain of the Company’s and such
Investor’s obligations are conditioned upon the execution and delivery of this Agreement by the parties hereto;  
 NOW,
THEREFORE, the Company and the Existing Investors hereby agree to amend and restate the Prior Agreement in its entirety as set forth herein, and all of the parties hereto further agree as follows: 

1. Definitions. For purposes of this Agreement: 

1.1 “Affiliate” means, with respect to any specified Person, any other Person who, directly or indirectly, controls, is
controlled by, or is under common control with such Person, including without limitation any general partner, managing member, officer or director of such Person or any venture capital or other investment fund now or hereafter existing that is
controlled by one or more general partners or managing members of, or shares the same management company or investment advisor with, such Person. 

1.2 “Common Stock” means shares of the Company’s common stock, par value $0.001 per share. 

1.3 “Damages” means any loss, damage, or liability (joint or several) to which a party hereto may become subject under the
Securities Act, the Exchange Act, or other federal or state law, insofar as such loss, damage, or liability (or any action in respect thereof) arises out of or is based upon (i) any untrue statement or alleged untrue statement of a material
fact contained in any registration statement of the Company, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto; (ii) an omission or alleged omission to state therein a material
fact required to be stated therein, or necessary to make the statements therein not misleading; or (iii) any violation or alleged 

  
 1 

 
violation by the indemnifying party (or any of its agents or Affiliates) of the Securities Act, the Exchange Act, any state securities law, or any rule or regulation promulgated under the
Securities Act, the Exchange Act, or any state securities law. 
 1.4 “Derivative Securities” means any securities or
rights convertible into, or exercisable or exchangeable for (in each case, directly or indirectly), Common Stock, including options and warrants. 

1.5 “Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations promulgated
thereunder. 
 1.6 “Excluded Registration” means (i) a registration relating to the sale of securities to employees of
the Company or a subsidiary pursuant to a stock option, stock purchase, or similar plan; (ii) a registration relating to an SEC Rule 145 transaction; (iii) a registration on any form that does not include substantially the same information
as would be required to be included in a registration statement covering the sale of the Registrable Securities; or (iv) a registration in which the only Common Stock being registered is Common Stock issuable upon conversion of debt securities
that are also being registered. 
 1.7 “Form S-1” means such form under the Securities Act as in effect on the date hereof
or any successor registration form under the Securities Act subsequently adopted by the SEC. 
 1.8 “Form S-3” means such
form under the Securities Act as in effect on the date hereof or any registration form under the Securities Act subsequently adopted by the SEC that permits incorporation of substantial information by reference to other documents filed by the
Company with the SEC. 
 1.9 “GAAP” means generally accepted accounting principles in the United States. 

1.10 “Holder” means any holder of Registrable Securities who is a party to this Agreement. 

1.11 “Immediate Family Member” means a child, stepchild, grandchild, parent, stepparent, grandparent, spouse, sibling,
mother-in-law, father-in-law, son-in-law, daughter-in-law, brother-in-law, or sister-in-law, including adoptive relationships, of a natural person referred to herein. 

1.12 “Initiating Holders” means, collectively, Holders who properly initiate a registration request under this Agreement.

 1.13 “IPO” means the Company’s first underwritten public offering of its Common Stock under the Securities Act.

 1.14 “Key Employee” means any executive-level employee (including division director and vice president-level positions)
as well as any employee who, either alone or in concert with others, develops, invents, programs, or designs any Company Intellectual Property (as defined in the Purchase Agreement). 

  
 2 

 1.15 “Major Investor” means (i) any Investor that, individually or together
with such Investor’s Affiliates, holds at least 281,000 shares of Registrable Securities (as adjusted for any stock split, stock dividend, combination, or other recapitalization or reclassification effected after the date hereof) and
(ii) any Investor that, individually or together with such Investor’s Affiliates, holds at least 164,430 shares of Series C Preferred Stock (as adjusted for any stock split, stock dividend, combination, or other recapitalization or
reclassification effected after the date hereof). 
 1.16 “New Securities” means, collectively, equity securities of the
Company, whether or not currently authorized, as well as rights, options, or warrants to purchase such equity securities, or securities of any type whatsoever that are, or may become, convertible or exchangeable into or exercisable for such equity
securities. 
 1.17 “Person” means any individual, corporation, partnership, trust, limited liability company, association
or other entity. 
 1.18 “Preferred Director” means the director of the Company that the holders of record of the Series A
Preferred Stock, Series B Preferred Stock and Series C Preferred Stock are entitled to elect pursuant to the Company’s Certificate of Incorporation. 

1.19 “Preferred Stock” means shares of Series A Preferred Stock, Series A-2 Preferred Stock, Series B Preferred Stock, Series
C Preferred Stock and Series D Preferred Stock. 
 1.20 “Registrable Securities” means (i) the Common Stock issuable
or issued upon conversion of the Preferred Stock; (ii) the Common Stock held by Flagship VentureLabs IV LLC as of the date of the Prior Agreement (including without limitation and for the avoidance of doubt the Common Stock acquired by
Nestlé Health Science US Holdings, Inc. (“Nestlé”) pursuant to the Stock Purchase Agreement dated as of December 19, 2014, by and between Flagship VentureLabs IV LLC and Nestlé (the “Common Stock
Purchase Agreement”); (iii) any Common Stock issued as (or issuable upon the conversion or exercise of any warrant, right, or other security that is issued as) a dividend or other distribution with respect to, or in exchange for or in
replacement of, the shares referenced in clause (i) and (ii) above; and (iv) the Common Stock issued or issuable to Comerica Ventures Incorporated, its successors and assigns, upon conversion of shares of any securities
of the Company (including without limitation Series A-2 Preferred Stock) issuable upon exercise of the warrant issued by the Company to Comerica Bank pursuant to that certain Loan and Security Agreement, dated as of September 9, 2013, between
the Company and Comerica Bank, as may be amended and/or restated from time to time; excluding in all cases, however, any Registrable Securities sold by a Person in a transaction in which the applicable rights under this Agreement are not assigned
pursuant to Subsection 6.1, and excluding for purposes of Section 2 any shares for which registration rights have terminated pursuant to Subsection 2.13 of this Agreement. 

  
 3 

 1.21 “Registrable Securities then outstanding” means the number of shares
determined by adding the number of shares of outstanding Common Stock that are Registrable Securities and the number of shares of Common Stock issuable (directly or indirectly) pursuant to then exercisable and/or convertible securities that are
Registrable Securities. 
 1.22 “Restricted Securities” means the securities of the Company required to bear the legend set
forth in Subsection 2.12(b) hereof. 
 1.23 “SEC” means the Securities and Exchange Commission. 

1.24 “SEC Rule 144” means Rule 144 promulgated by the SEC under the Securities Act. 

1.25 “SEC Rule 145” means Rule 145 promulgated by the SEC under the Securities Act. 

1.26 “Securities Act” means the Securities Act of 1933, as amended, and the rules and regulations promulgated thereunder.

 1.27 “Selling Expenses” means all underwriting discounts, selling commissions, and stock transfer taxes applicable to
the sale of Registrable Securities, and fees and disbursements of counsel for any Holder, except for the fees and disbursements of the Selling Holder Counsel borne and paid by the Company as provided in Subsection 2.6. 

1.28 “Series A Preferred Stock” means shares of the Company’s Series A Preferred Stock, par value $0.001 per share. 

1.29 “Series A-2 Preferred Stock” means shares of the Company’s Series A-2 Preferred Stock, par value $0.001 per share.

 1.30 “Series B Preferred Stock” means shares of the Company’s Series B Preferred Stock, par value $0.001 per share.

 1.31 “Series C Preferred Stock” means shares of the Company’s Series C Preferred Stock, par value $0.001 per share.

 1.32 “Series C Purchase Agreement” means that certain Series C Preferred Stock Purchase Agreement, dated as of
November 24, 2014, by and among the Company and the purchasers named therein. 
 1.33 “Series D Preferred Stock” means
shares of the Company’s Series D Preferred Stock, par value $0.001 per share. 
 1.34 “Series D-1 Preferred Stock”
means shares of the Company’s Series D-1 Preferred Stock, par value $0.001 per share. 

  
 4 

 2. Registration Rights. The Company covenants and agrees as follows: 

2.1 Demand Registration. 

(a) Form S-1 Demand. If at any time after the earlier of (i) five (5) years after the date of this Agreement or
(ii) one hundred eighty (180) days after the effective date of the registration statement for the IPO, the Company receives a request from Holders of a majority of the Registrable Securities then outstanding that the Company file a Form
S-1 registration statement for which the anticipated aggregate offering price would exceed $10,000,000, then the Company shall (i) within ten (10) days after the date such request is given, give notice thereof (the “Demand
Notice”) to all Holders other than the Initiating Holders; and (ii) as soon as practicable, and in any event within sixty (60) days after the date such request is given by the Initiating Holders, file a Form S-1 registration
statement under the Securities Act covering all Registrable Securities that the Initiating Holders requested to be registered and any additional Registrable Securities requested to be included in such registration by any other Holders, as specified
by notice given by each such Holder to the Company within twenty (20) days of the date the Demand Notice is given, and in each case, subject to the limitations of Subsection 2.1(c) and Subsection 2.3. 

(b) Form S-3 Demand. If at any time when it is eligible to use a Form S-3 registration statement, the Company receives a request from
Holders of at least thirty percent (30%) of the Registrable Securities then outstanding that the Company file a Form S-3 registration statement with respect to outstanding Registrable Securities of such Holders having an anticipated aggregate
offering price of at least $5,000,000, then the Company shall (i) within ten (10) days after the date such request is given, give a Demand Notice to all Holders other than the Initiating Holders; and (ii) as soon as practicable, and
in any event within forty-five (45) days after the date such request is given by the Initiating Holders, file a Form S-3 registration statement under the Securities Act covering all Registrable Securities requested to be included in such
registration by any other Holders, as specified by notice given by each such Holder to the Company within twenty (20) days of the date the Demand Notice is given, and in each case, subject to the limitations of Subsection 2.1(c) and
Subsection 2.3. 
 (c) Notwithstanding the foregoing obligations, if the Company furnishes to Holders requesting a registration
pursuant to this Subsection 2.1 a certificate signed by the Company’s chief executive officer stating that in the good faith judgment of the Company’s Board of Directors it would be materially detrimental to the Company and its
stockholders for such registration statement to either become effective or remain effective for as long as such registration statement otherwise would be required to remain effective, because such action would (i) materially interfere with a
significant acquisition, corporate reorganization, or other similar transaction involving the Company; (ii) require premature disclosure of material information that the Company has a bona fide business purpose for preserving as confidential;
or (iii) render the Company unable to comply with requirements under the Securities Act or Exchange Act, then the Company shall have the right to defer taking action with respect to such filing, and any time periods with respect to filing or
effectiveness thereof shall be tolled correspondingly, for a period of not more than ninety (90) days after the request of the Initiating Holders is given; provided, however, that the Company may not invoke this right more than
once 

  
 5 

 
in any twelve (12) month period; and provided further that the Company shall not register any securities for its own account or that of any other stockholder during such ninety
(90) day period other than an Excluded Registration. 
 (d) The Company shall not be obligated to effect, or to take any action to
effect, any registration pursuant to Subsection 2.1(a) (i) during the period that is sixty (60) days before the Company’s good faith estimate of the date of filing of, and ending on a date that is one hundred eighty
(180) days after the effective date of, a Company-initiated registration, provided, that the Company is actively employing in good faith commercially reasonable efforts to cause such registration statement to become effective;
(ii) after the Company has effected two registrations pursuant to Subsection 2.1(a); or (iii) if the Initiating Holders propose to dispose of shares of Registrable Securities that may be immediately registered on Form S-3 pursuant
to a request made pursuant to Subsection 2.1(b). The Company shall not be obligated to effect, or to take any action to effect, any registration pursuant to Subsection 2.1(b) (i) during the period that is thirty
(30) days before the Company’s good faith estimate of the date of filing of, and ending on a date that is ninety (90) days after the effective date of, a Company-initiated registration, provided, that the Company is actively employing
in good faith commercially reasonable efforts to cause such registration statement to become effective; or (ii) if the Company has effected two registrations pursuant to Subsection 2.1(b) within the twelve (12) month period
immediately preceding the date of such request. A registration shall not be counted as “effected” for purposes of this Subsection 2.1(d) until such time as the applicable registration statement has been declared effective by the
SEC, unless the Initiating Holders withdraw their request for such registration, elect not to pay the registration expenses therefor, and forfeit their right to one demand registration statement pursuant to Subsection 2.6, in which case
such withdrawn registration statement shall be counted as “effected” for purposes of this Subsection 2.1(d). 
 2.2
Company Registration. If the Company proposes to register (including, for this purpose, a registration effected by the Company for stockholders other than the Holders) any of its securities under the Securities Act in connection with the
public offering of such securities solely for cash (other than in an Excluded Registration or the IPO), the Company shall, at such time, promptly give each Holder notice of such registration. Upon the request of each Holder given within twenty
(20) days after such notice is given by the Company, the Company shall, subject to the provisions of Subsection 2.3, cause to be registered all of the Registrable Securities that each such Holder has requested to be included in such
registration. The Company shall have the right to terminate or withdraw any registration initiated by it under this Subsection 2.2 before the effective date of such registration, whether or not any Holder has elected to include Registrable
Securities in such registration. The expenses (other than Selling Expenses) of such withdrawn registration shall be borne by the Company in accordance with Subsection 2.6. 

2.3 Underwriting Requirements. 

(a) If, pursuant to Subsection 2.1, the Initiating Holders intend to distribute the Registrable Securities covered by their request by
means of an underwriting, they shall so advise the Company as a part of their request made pursuant to Subsection 2.1, and the Company shall include such information in the Demand Notice. The underwriter(s) will be selected by a majority in
interest of the Initiating Holders, subject only to the reasonable approval of the Company. In such event, the right of any Holder to include such 

  
 6 

 
Holder’s Registrable Securities in such registration shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable
Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their securities through such underwriting shall (together with the Company as provided in Subsection 2.4(e)) enter into an underwriting
agreement in customary form with the underwriter(s) selected for such underwriting. Notwithstanding any other provision of this Subsection 2.3, if the managing underwriter(s) advise(s) the Initiating Holders in writing that marketing factors
require a limitation on the number of shares to be underwritten, then the Initiating Holders shall so advise all Holders of Registrable Securities that otherwise would be underwritten pursuant hereto, and the number of Registrable Securities that
may be included in the underwriting shall be allocated among such Holders of Registrable Securities, including the Initiating Holders, in proportion (as nearly as practicable) to the number of Registrable Securities owned by each Holder or in such
other proportion as shall mutually be agreed to by all such selling Holders; provided, however, that the number of Registrable Securities held by the Holders to be included in such underwriting shall not be reduced unless all other
securities are first entirely excluded from the underwriting. To facilitate the allocation of shares in accordance with the above provisions, the Company or the underwriters may round the number of shares allocated to any Holder to the nearest 100
shares. 
 (b) In connection with any offering involving an underwriting of shares of the Company’s capital stock pursuant to
Subsection 2.2, the Company shall not be required to include any of the Holders’ Registrable Securities in such underwriting unless the Holders accept the terms of the underwriting as agreed upon between the Company and its underwriters,
and then only in such quantity as the underwriters in their sole discretion determine will not jeopardize the success of the offering by the Company. If the total number of securities, including Registrable Securities, requested by stockholders to
be included in such offering exceeds the number of securities to be sold (other than by the Company) that the underwriters in their reasonable discretion determine is compatible with the success of the offering, then the Company shall be required to
include in the offering only that number of such securities, including Registrable Securities, which the underwriters and the Company in their sole discretion determine will not jeopardize the success of the offering. If the underwriters determine
that less than all of the Registrable Securities requested to be registered can be included in such offering, then the Registrable Securities that are included in such offering shall be allocated among the selling Holders in proportion (as nearly as
practicable to) the number of Registrable Securities owned by each selling Holder or in such other proportions as shall mutually be agreed to by all such selling Holders. To facilitate the allocation of shares in accordance with the above
provisions, the Company or the underwriters may round the number of shares allocated to any Holder to the nearest 100 shares. Notwithstanding the foregoing, in no event shall (i) the number of Registrable Securities included in the offering be
reduced unless all other securities (other than securities to be sold by the Company) are first entirely excluded from the offering, and (ii) the number of Registrable Securities included in the offering be reduced below thirty percent
(30%) of the total number of securities included in such offering. For purposes of the provision in this Subsection 2.3(b) concerning apportionment, for any selling Holder that is a partnership, limited liability company, or corporation,
the partners, members, retired partners, retired members, stockholders, and Affiliates of such Holder, or the estates and Immediate Family Members of any such partners, retired partners, members, and retired members and any trusts for

  
 7 

 
the benefit of any of the foregoing Persons, shall be deemed to be a single “selling Holder,” and any pro rata reduction with respect to such “selling Holder” shall be based
upon the aggregate number of Registrable Securities owned by all Persons included in such “selling Holder,” as defined in this sentence. 

(c) For purposes of Subsection 2.1, a registration shall not be counted as “effected” if, as a result of an exercise of the
underwriter’s cutback provisions in Subsection 2.3(a), fewer than fifty percent (50%) of the total number of Registrable Securities that Holders have requested to be included in such registration statement are actually included.

 2.4 Obligations of the Company. Whenever required under this Section 2 to effect the registration of any Registrable
Securities, the Company shall, as expeditiously as reasonably possible: 
 (a) prepare and file with the SEC a registration statement with
respect to such Registrable Securities and use its commercially reasonable efforts to cause such registration statement to become effective and, upon the request of the Holders of a majority of the Registrable Securities registered thereunder, keep
such registration statement effective for a period of up to one hundred twenty (120) days or, if earlier, until the distribution contemplated in the registration statement has been completed; provided, however, that (i) such
one hundred twenty (120) day period shall be extended for a period of time equal to the period the Holder refrains, at the request of an underwriter of Common Stock (or other securities) of the Company, from selling any securities included in
such registration, and (ii) in the case of any registration of Registrable Securities on Form S-3 that are intended to be offered on a continuous or delayed basis, subject to compliance with applicable SEC rules, such one hundred twenty
(120) day period shall be extended, if necessary, to keep the registration statement effective until all such Registrable Securities are sold; 

(b) prepare and file with the SEC such amendments and supplements to such registration statement, and the prospectus used in connection with
such registration statement, as may be necessary to comply with the Securities Act in order to enable the disposition of all securities covered by such registration statement; 

(c) furnish to the selling Holders such numbers of copies of a prospectus, including a preliminary prospectus, as required by the Securities
Act, and such other documents as the Holders may reasonably request in order to facilitate their disposition of their Registrable Securities; 

(d) use its commercially reasonable efforts to register and qualify the securities covered by such registration statement under such other
securities or blue-sky laws of such jurisdictions as shall be reasonably requested by the selling Holders; provided that the Company shall not be required to qualify to do business or to file a general consent to service of process in any such
states or jurisdictions, unless the Company is already subject to service in such jurisdiction and except as may be required by the Securities Act; 

  
 8 

 (e) in the event of any underwritten public offering, enter into and perform its obligations
under an underwriting agreement, in usual and customary form, with the underwriter(s) of such offering; 
 (f) use its commercially
reasonable efforts to cause all such Registrable Securities covered by such registration statement to be listed on a national securities exchange or trading system and each securities exchange and trading system (if any) on which similar securities
issued by the Company are then listed; 
 (g) provide a transfer agent and registrar for all Registrable Securities registered pursuant to
this Agreement and provide a CUSIP number for all such Registrable Securities, in each case not later than the effective date of such registration; 

(h) promptly make available for inspection by the selling Holders, any managing underwriter(s) participating in any disposition pursuant to
such registration statement, and any attorney or accountant or other agent retained by any such underwriter or selected by the selling Holders, all financial and other records, pertinent corporate documents, and properties of the Company, and cause
the Company’s officers, directors, employees, and independent accountants to supply all information reasonably requested by any such seller, underwriter, attorney, accountant, or agent, in each case, as necessary or advisable to verify the
accuracy of the information in such registration statement and to conduct appropriate due diligence in connection therewith; 
 (i) notify
each selling Holder, promptly after the Company receives notice thereof, of the time when such registration statement has been declared effective or a supplement to any prospectus forming a part of such registration statement has been filed; and

 (j) after such registration statement becomes effective, notify each selling Holder of any request by the SEC that the Company amend or
supplement such registration statement or prospectus. 
 In addition, the Company shall ensure that, at all times after any registration
statement covering a public offering of securities of the Company under the Securities Act shall have become effective, its insider trading policy shall provide that the Company’s directors may implement a trading program under Rule 10b5-1 of
the Exchange Act. 
 2.5 Furnish Information. It shall be a condition precedent to the obligations of the Company to take any action
pursuant to this Section 2 with respect to the Registrable Securities of any selling Holder that such Holder shall furnish to the Company such information regarding itself, the Registrable Securities held by it, and the intended method
of disposition of such securities as is reasonably required to effect the registration of such Holder’s Registrable Securities. 
 2.6
Expenses of Registration. All expenses (other than Selling Expenses) incurred in connection with registrations, filings, or qualifications pursuant to Section 2, including all registration, filing, and qualification fees;
printers’ and accounting fees; fees and 

  
 9 

 
disbursements of counsel for the Company; and the reasonable fees and disbursements of one counsel for the selling Holders selected by the Holders of a majority of the Registrable Securities to
be registered (“Selling Holder Counsel”), shall be borne and paid by the Company; provided, however, that the Company shall not be required to pay for any expenses of any registration proceeding begun pursuant to
Subsection 2.1 if the registration request is subsequently withdrawn at the request of the Holders of a majority of the Registrable Securities to be registered (in which case all selling Holders shall bear such expenses pro rata based upon
the number of Registrable Securities that were to be included in the withdrawn registration), unless the Holders of a majority of the Registrable Securities agree to forfeit their right to one registration pursuant to Subsection 2.1(a) or
Subsection 2.1(b), as the case may be; provided further that if, at the time of such withdrawal, the Holders shall have learned of a material adverse change in the condition, business, or prospects of the Company from that known
to the Holders at the time of their request and have withdrawn the request with reasonable promptness after learning of such information then the Holders shall not be required to pay any of such expenses and shall not forfeit their right to one
registration pursuant to Subsection 2.1(a) or Subsection 2.1(b). All Selling Expenses relating to Registrable Securities registered pursuant to this Section 2 shall be borne and paid by the Holders pro rata on the basis of
the number of Registrable Securities registered on their behalf. 
 2.7 Delay of Registration. No Holder shall have any right to
obtain or seek an injunction restraining or otherwise delaying any registration pursuant to this Agreement as the result of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 

2.8 Indemnification. If any Registrable Securities are included in a registration statement under this Section 2: 

(a) To the extent permitted by law, the Company will indemnify and hold harmless each selling Holder, and the partners, members, officers,
directors, and stockholders of each such Holder; legal counsel, accountants and investment advisors for each such Holder; any underwriter (as defined in the Securities Act) for each such Holder; and each Person, if any, who controls such Holder or
underwriter within the meaning of the Securities Act or the Exchange Act, against any Damages, and the Company will pay to each such Holder, underwriter, controlling Person, or other aforementioned Person any legal or other expenses reasonably
incurred thereby in connection with investigating or defending any claim or proceeding from which Damages may result, as such expenses are incurred; provided, however, that the indemnity agreement contained in this Subsection
2.8(a) shall not apply to amounts paid in settlement of any such claim or proceeding if such settlement is effected without the consent of the Company, which consent shall not be unreasonably withheld, nor shall the Company be liable for any
Damages to the extent that they arise out of or are based upon actions or omissions made in reliance upon and in conformity with written information furnished by or on behalf of any such Holder, underwriter, controlling Person, or other
aforementioned Person expressly for use in connection with such registration. 
 (b) To the extent permitted by law, each selling Holder,
severally and not jointly, will indemnify and hold harmless the Company, and each of its directors, each of its 

  
 10 

 
officers who has signed the registration statement, each Person (if any), who controls the Company within the meaning of the Securities Act, legal counsel and accountants for the Company, any
underwriter (as defined in the Securities Act), any other Holder selling securities in such registration statement, and any controlling Person of any such underwriter or other Holder, against any Damages, in each case only to the extent that such
Damages arise out of or are based upon actions or omissions made in reliance upon and in conformity with written information furnished by or on behalf of such selling Holder expressly for use in connection with such registration; and each such
selling Holder will pay to the Company and each other aforementioned Person any legal or other expenses reasonably incurred thereby in connection with investigating or defending any claim or proceeding from which Damages may result, as such expenses
are incurred; provided, however, that the indemnity agreement contained in this Subsection 2.8(b) shall not apply to amounts paid in settlement of any such claim or proceeding if such settlement is effected without the consent
of the Holder, which consent shall not be unreasonably withheld; and provided further that in no event shall the aggregate amounts payable by any Holder by way of indemnity or contribution under Subsections 2.8(b) and
2.8(d) exceed the proceeds from the offering received by such Holder (net of any Selling Expenses paid by such Holder), except in the case of fraud or willful misconduct by such Holder. 

(c) Promptly after receipt by an indemnified party under this Subsection 2.8 of notice of the commencement of any action (including
any governmental action) for which a party may be entitled to indemnification hereunder, such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Subsection 2.8, give the indemnifying
party notice of the commencement thereof. The indemnifying party shall have the right to participate in such action and, to the extent the indemnifying party so desires, participate jointly with any other indemnifying party to which notice has been
given, and to assume the defense thereof with counsel mutually satisfactory to the parties; provided, however, that an indemnified party (together with all other indemnified parties that may be represented without conflict by one
counsel) shall have the right to retain one separate counsel, with the fees and expenses to be paid by the indemnifying party, if representation of such indemnified party by the counsel retained by the indemnifying party would be inappropriate due
to actual or potential differing interests between such indemnified party and any other party represented by such counsel in such action. The failure to give notice to the indemnifying party within a reasonable time of the commencement of any such
action shall relieve such indemnifying party of any liability to the indemnified party under this Subsection 2.8, to the extent that such failure materially prejudices the indemnifying party’s ability to defend such action. The
failure to give notice to the indemnifying party will not relieve it of any liability that it may have to any indemnified party otherwise than under this Subsection 2.8. 

(d) To provide for just and equitable contribution to joint liability under the Securities Act in any case in which either (i) any party
otherwise entitled to indemnification hereunder makes a claim for indemnification pursuant to this Subsection 2.8 but it is judicially determined (by the entry of a final judgment or decree by a court of competent jurisdiction and the
expiration of time to appeal or the denial of the last right of appeal) that such indemnification may not be enforced in such case, notwithstanding the fact that this Subsection 2.8 provides for indemnification in such case, or
(ii) contribution under the Securities Act may 

  
 11 

 
be required on the part of any party hereto for which indemnification is provided under this Subsection 2.8, then, and in each such case, such parties will contribute to the aggregate
losses, claims, damages, liabilities, or expenses to which they may be subject (after contribution from others) in such proportion as is appropriate to reflect the relative fault of each of the indemnifying party and the indemnified party in
connection with the statements, omissions, or other actions that resulted in such loss, claim, damage, liability, or expense, as well as to reflect any other relevant equitable considerations. The relative fault of the indemnifying party and of the
indemnified party shall be determined by reference to, among other things, whether the untrue or allegedly untrue statement of a material fact, or the omission or alleged omission of a material fact, relates to information supplied by the
indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information, and opportunity to correct or prevent such statement or omission; provided, however, that, in any such case,
(x) no Holder will be required to contribute any amount in excess of the public offering price of all such Registrable Securities offered and sold by such Holder pursuant to such registration statement, and (y) no Person guilty of
fraudulent misrepresentation (within the meaning of Section 11(f) of the Securities Act) will be entitled to contribution from any Person who was not guilty of such fraudulent misrepresentation; and provided further that in no
event shall a Holder’s liability pursuant to this Subsection 2.8(d), when combined with the amounts paid or payable by such Holder pursuant to Subsection 2.8(b), exceed the proceeds from the offering received by such Holder (net
of any Selling Expenses paid by such Holder), except in the case of willful misconduct or fraud by such Holder. 
 (e) Notwithstanding the
foregoing, to the extent that the provisions on indemnification and contribution contained in the underwriting agreement entered into in connection with the underwritten public offering are in conflict with the foregoing provisions, the provisions
in the underwriting agreement shall control. 
 (f) Unless otherwise superseded by an underwriting agreement entered into in connection
with the underwritten public offering, the obligations of the Company and Holders under this Subsection 2.8 shall survive the completion of any offering of Registrable Securities in a registration under this Section 2, and
otherwise shall survive the termination of this Agreement. 
 2.9 Reports Under Exchange Act. With a view to making available to the
Holders the benefits of SEC Rule 144 and any other rule or regulation of the SEC that may at any time permit a Holder to sell securities of the Company to the public without registration or pursuant to a registration on Form S-3, the Company shall:

 (a) make and keep available adequate current public information, as those terms are understood and defined in SEC Rule 144, at all times
after the effective date of the registration statement filed by the Company for the IPO; 
 (b) use commercially reasonable efforts to file
with the SEC in a timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act (at any time after the Company has become subject to such reporting requirements); and 

  
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 (c) furnish to any Holder, so long as the Holder owns any Registrable Securities, forthwith upon
request (i) to the extent accurate, a written statement by the Company that it has complied with the reporting requirements of SEC Rule 144 (at any time after ninety (90) days after the effective date of the registration statement filed by
the Company for the IPO), the Securities Act, and the Exchange Act (at any time after the Company has become subject to such reporting requirements), or that it qualifies as a registrant whose securities may be resold pursuant to Form S 3
(at any time after the Company so qualifies); (ii) a copy of the most recent annual or quarterly report of the Company and such other reports and documents so filed by the Company; and (iii) such other information as may be reasonably
requested in availing any Holder of any rule or regulation of the SEC that permits the selling of any such securities without registration (at any time after the Company has become subject to the reporting requirements under the Exchange Act) or
pursuant to Form S-3 (at any time after the Company so qualifies to use such form). 
 2.10 Limitations on Subsequent Registration
Rights. From and after the date of this Agreement, the Company shall not, without the prior written consent of the Holders of a majority of the Registrable Securities then outstanding, enter into any agreement with any holder or prospective
holder of any securities of the Company that (i) would provide to such holder the right to include securities in any registration on other than a subordinate basis after all Holders have had the opportunity to include in the registration and
offering all shares of Registrable Securities that they wish to so include or (ii) allow such holder or prospective holder to initiate a demand for registration of any securities held by such holder or prospective holder. 

2.11 “Market Stand off” Agreement. Each Holder hereby agrees that it will not, without the prior written consent of the
managing underwriter, during the period commencing on the date of the final prospectus relating to the IPO and ending on the date specified by the Company and the managing underwriter (such period not to exceed one hundred eighty (180) days),
(i) lend; offer; pledge; sell; contract to sell; sell any option or contract to purchase; purchase any option or contract to sell; grant any option, right, or warrant to purchase; or otherwise transfer or dispose of, directly or indirectly, any
shares of Common Stock or any securities convertible into or exercisable or exchangeable (directly or indirectly) for Common Stock held immediately before the effective date of the registration statement for such offering or (ii) enter into any
swap or other arrangement that transfers to another, in whole or in part, any of the economic consequences of ownership of such securities, whether any such transaction described in clause (i) or (ii) above is to be settled by delivery of
Common Stock or other securities, in cash, or otherwise. The foregoing provisions of this Subsection 2.11 shall apply only to the IPO, shall not apply to the sale of any shares to an underwriter pursuant to an underwriting agreement for such
IPO, and shall be applicable to the Holders only if all officers and directors of the Company and holders of at least one percent (1%) of the outstanding Common Stock (after giving effect to conversion into Common Stock of all outstanding
shares of Preferred Stock) are subject to the same restrictions. The underwriters in connection with such registration are intended third party beneficiaries of this Subsection 2.11 and shall have the right, power, and authority to enforce
the provisions hereof as though they were a party hereto. Each Holder further agrees to execute such agreements as may be reasonably requested by the underwriters in connection with such registration that are consistent with this Subsection
2.11 or that are necessary to give further effect thereto. 

  
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 2.12 Restrictions on Transfer. 

(a) The Preferred Stock and the Registrable Securities shall not be sold, pledged, or otherwise transferred in violation of this Agreement,
and the Company shall not recognize and shall issue stop-transfer instructions to its transfer agent with respect to any such sale, pledge, or transfer, except upon the conditions specified in this Agreement, which conditions are intended to ensure
compliance with the provisions of the Securities Act. A transferring Holder will cause any proposed purchaser, pledgee, or transferee of the Preferred Stock and the Registrable Securities held by such Holder to agree to take and hold such securities
subject to the provisions and upon the conditions specified in this Agreement. Notwithstanding the foregoing, the Company shall not require any transferee of Registrable Securities pursuant to an effective registration statement under the Securities
Act or, following the IPO, SEC Rule 144 to be bound by the terms of this Subsection 2.12 if the transferred securities do not remain Registrable Securities hereunder following such transfer. 

(b) Each certificate or instrument representing (i) the Preferred Stock, (ii) the Registrable Securities, and (iii) any other
securities issued in respect of the securities referenced in clauses (i) and (ii), upon any stock split, stock dividend, recapitalization, merger, consolidation, or similar event, shall (unless otherwise permitted by the provisions of
Subsection 2.12(c)) be stamped or otherwise imprinted with a legend substantially in the following form: 
 THE SECURITIES REPRESENTED
HEREBY HAVE BEEN ACQUIRED FOR INVESTMENT AND HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933. SUCH SHARES MAY NOT BE SOLD, PLEDGED, OR TRANSFERRED IN THE ABSENCE OF SUCH REGISTRATION OR A VALID EXEMPTION FROM THE REGISTRATION AND
PROSPECTUS DELIVERY REQUIREMENTS OF SAID ACT. 
 THE SECURITIES REPRESENTED HEREBY MAY BE TRANSFERRED ONLY IN ACCORDANCE WITH THE TERMS OF AN
AGREEMENT BETWEEN THE COMPANY AND THE STOCKHOLDER, A COPY OF WHICH IS ON FILE WITH THE SECRETARY OF THE COMPANY. 
 The Holders consent to
the Company making a notation in its records and giving instructions to any transfer agent of the Restricted Securities in order to implement the restrictions on transfer set forth in this Subsection 2.12. 

(c) The holder of each certificate representing Restricted Securities, by acceptance thereof, agrees to comply in all respects with the
provisions of this Section 2. Before any proposed sale, pledge, or transfer of any Restricted Securities, unless there is in effect a registration statement under the Securities Act covering the proposed transaction or, following the
IPO, the transfer is made pursuant to SEC Rule 144, the Holder thereof shall give notice to the Company of such Holder’s intention to effect such sale, pledge, or transfer. Each such notice shall describe the manner and circumstances of the
proposed sale, pledge, or transfer in sufficient detail and, if reasonably requested by the Company, shall be accompanied at such Holder’s expense by either (i) a written opinion of legal counsel who shall, and whose legal opinion shall,
be reasonably satisfactory to the Company, addressed to the Company, to the effect that the proposed transaction may be effected without registration under the Securities Act; (ii) a “no 

  
 14 

 
action” letter from the SEC to the effect that the proposed sale, pledge, or transfer of such Restricted Securities without registration will not result in a recommendation by the staff of
the SEC that action be taken with respect thereto; or (iii) any other evidence reasonably satisfactory to counsel to the Company to the effect that the proposed sale, pledge, or transfer of the Restricted Securities may be effected without
registration under the Securities Act, whereupon the Holder of such Restricted Securities shall be entitled to sell, pledge, or transfer such Restricted Securities in accordance with the terms of the notice given by the Holder to the Company. The
Company will not require such a legal opinion or “no action” letter (x) in any transaction in compliance with SEC Rule 144 or (y) in any transaction in which such Holder distributes Restricted Securities to an Affiliate of such
Holder for no consideration; provided that, with respect to transfers following the IPO under the foregoing clause (y), each transferee agrees in writing to be subject to the terms of this Subsection 2.12. Each certificate or instrument
evidencing the Restricted Securities transferred as above provided shall bear, except if such transfer is made pursuant to SEC Rule 144 or pursuant to an effective registration statement under the Securities Act, the appropriate restrictive legend
set forth in Subsection 2.12(b), except that such certificate shall not bear such restrictive legend if, in the opinion of counsel for such Holder and the Company, such legend is not required in order to establish compliance with any
provisions of the Securities Act. 
 2.13 Termination of Registration Rights. The right of any Holder to request registration or
inclusion of Registrable Securities in any registration pursuant to Subsection 2.1 or Subsection 2.2 shall terminate upon the earliest to occur of: 

(a) the closing of a Deemed Liquidation Event, as such term is defined in the Company’s Certificate of Incorporation; 

(b) such time after the IPO as SEC Rule 144 or another similar exemption under the Securities Act is available for the sale of all of such
Holder’s shares without limitation during a three-month period without registration; and 
 (c) the fifth (5th) anniversary of the IPO. 
 3. Information Rights. 

3.1 Delivery of Financial Statements. The Company shall deliver to each Major Investor and each Investor owning shares of Series C
Preferred Stock purchased from the Company pursuant to the Series C Purchase Agreement, provided that the Board of Directors has not reasonably determined that such Major Investor or Investor, as the case may be, is a competitor of the
Company: 
 (a) as soon as practicable, but in any event within one hundred twenty (120) days after the end of each fiscal year of the
Company, (i) a balance sheet as of the end of such year, (ii) statements of income and of cash flows for such year and (iii) a statement of stockholders’ equity as of the end of such year, all such financial statements audited
and certified by independent public accountants selected by the Company and approved by the Board of Directors, including the Preferred Director; 

  
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 (b) as soon as practicable, but in any event within forty-five (45) days after the end of
each of the first three (3) quarters of each fiscal year of the Company, unaudited statements of income and of cash flows for such fiscal quarter, and an unaudited balance sheet and a statement of stockholders’ equity as of the end of such
fiscal quarter, all prepared in accordance with GAAP (except that such financial statements may (i) be subject to normal year-end audit adjustments and (ii) not contain all notes thereto that may be required in accordance with GAAP); 

(c) as soon as practicable, but in any event within forty-five (45) days after the end of each of the first three (3) quarters of
each fiscal year of the Company, a statement showing the number of shares of each class and series of capital stock and securities convertible into or exercisable for shares of capital stock outstanding at the end of the period, the Common Stock
issuable upon conversion or exercise of any outstanding securities convertible or exercisable for Common Stock and the exchange ratio or exercise price applicable thereto, and the number of shares of issued stock options and stock options not yet
issued but reserved for issuance, if any, all in sufficient detail as to permit any Major Investor to calculate its percentage equity ownership in the Company, and certified by the chief financial officer or chief executive officer of the Company as
being true, complete, and correct; and 
 (d) such other information relating to the financial condition, business, prospects, or corporate
affairs of the Company as any Major Investor may from time to time reasonably request; provided, however, that the Company shall not be obligated under this Subsection 3.1 to provide information (i) that the Company
reasonably determines in good faith to be confidential information (unless covered by an enforceable confidentiality agreement, in form acceptable to the Company) or a trade secret or (ii) the disclosure of which would adversely affect the
attorney-client privilege between the Company and its counsel. 
 If, for any period, the Company has any subsidiary whose accounts are
consolidated with those of the Company, then in respect of such period the financial statements delivered pursuant to the foregoing sections shall be the consolidated and consolidating financial statements of the Company and all such consolidated
subsidiaries. 
 Notwithstanding anything else in this Subsection 3.1 to the contrary, the Company may cease providing the
information set forth in this Subsection 3.1 during the period starting with the date sixty (60) days before the Company’s good-faith estimate of the date of filing of a registration statement if it reasonably concludes it must do
so to comply with the SEC rules applicable to such registration statement and related offering; provided that the Company’s covenants under this Subsection 3.1 shall be reinstated at such time as the Company is no longer actively
employing its commercially reasonable efforts to cause such registration statement to become effective. 
 Notwithstanding anything else in
this Subsection 3.1 to the contrary, (x) the Company shall not be obligated to provide any information under Subsection 3.1(d) to the Major Investor that purchased Series D Preferred Stock from the Company pursuant to the Purchase
Agreement, or any of its permitted transferees, and (y) the Company shall not be obligated to provide any information under Subsection 3.1 to the Major Investor that purchased Series D Preferred Stock

  
 16 

 
from the Company pursuant to the Purchase Agreement, or any of its permitted transferees, unless such Major Investor continues to own shares representing at least fifty percent (50%) of the
combined aggregate voting power of (1) the shares of Series D Preferred Stock and Series D-1 Preferred Stock purchased by such Major Investor pursuant to the Purchase Agreement and (2) the shares of Common Stock purchased by such Major
Investor pursuant to the Stock Purchase Agreement, dated as of December 19, 2014, by and between the Flagship VentureLabs IV LLC and such Major Investor. 

3.2 Inspection. The Company shall permit each Major Investor (provided that the Board of Directors has not reasonably determined that
such Major Investor is a competitor of the Company), at such Major Investor’s expense, to visit and inspect the Company’s properties; examine its books of account and records; and discuss the Company’s affairs, finances, and accounts
with its officers, during normal business hours of the Company as may be reasonably requested by the Major Investor; provided, however, that the Company shall not be obligated pursuant to this Subsection 3.2 to provide access to
any information that it reasonably and in good faith considers to be confidential information (unless covered by an enforceable confidentiality agreement, in form acceptable to the Company) or a trade secret or the disclosure of which would
adversely affect the attorney-client privilege between the Company and its counsel. 
 3.3 Termination of Information Rights. The
covenants set forth in Subsection 3.1 and Subsection 3.2 shall terminate and be of no further force or effect (i) immediately before the consummation of the IPO, (ii) when the Company first becomes subject to the periodic
reporting requirements of Section 12(g) or 15(d) of the Exchange Act, or (iii) upon a Deemed Liquidation Event, as such term is defined in the Company’s Certificate of Incorporation, unless the consideration received by the Investors
is in the form of securities that are privately held, whichever event occurs first. 
 3.4 Confidentiality. Each Investor agrees that
such Investor will keep confidential and will not disclose, divulge, or use for any purpose (other than to monitor its investment in the Company) any confidential information obtained from the Company pursuant to the terms of this Agreement
(including notice of the Company’s intention to file a registration statement), unless such confidential information (a) is known or becomes known to the public in general (other than as a result of a breach of this Subsection 3.4
by such Investor), (b) is or has been independently developed or conceived by any Investor without use of the Company’s confidential information, or (c) is or has been made known or disclosed to any Investor by a third party without a
breach of any obligation of confidentiality such third party may have to the Company; provided, however, that an Investor may disclose confidential information: (i) to its attorneys, accountants, consultants, and other
professionals to the extent necessary to obtain their services in connection with monitoring its investment in the Company; (ii) to any prospective purchaser of any Registrable Securities from such Investor, if such prospective purchaser agrees
to be bound by the provisions of this Subsection 3.4; (iii) to any existing or prospective Affiliate, partner, member, stockholder, or wholly owned subsidiary of such Investor in the ordinary course of business, provided
that such Investor informs such Person that such information is confidential and directs such Person to maintain the confidentiality of such information; or (iv) as may otherwise be required by law, provided that such
Investor promptly notifies the Company of such disclosure and takes reasonable steps to minimize the extent of any such required disclosure. 

  
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 4. Rights to Future Stock Issuances. 

4.1 Right of First Offer. Subject to the terms and conditions of this Subsection 4.1 and applicable securities laws, if the
Company proposes to offer or sell any New Securities, the Company shall first offer such New Securities to each Major Investor. A Major Investor shall be entitled to apportion the right of first offer hereby granted to it among itself and its
Affiliates in such proportions as it deems appropriate. 
 (a) The Company shall give notice (the “Offer Notice”) to each
Major Investor, stating (i) its bona fide intention to offer such New Securities, (ii) the number of such New Securities to be offered, and (iii) the price and terms, if any, upon which it proposes to offer such New Securities. 

(b) By notification to the Company within twenty (20) days after the Offer Notice is given, each Major Investor may elect to purchase or
otherwise acquire, at the price and on the terms specified in the Offer Notice, up to that portion of such New Securities which equals the proportion that the Common Stock issued and held, or issuable (directly or indirectly) upon conversion and/or
exercise, as applicable, of the Preferred Stock and any other Derivative Securities then held, by such Major Investor bears to the total Common Stock of the Company then outstanding (assuming full conversion and/or exercise, as applicable, of all
Preferred Stock and other Derivative Securities). At the expiration of such twenty (20) day period, the Company shall promptly notify each Major Investor that elects to purchase or acquire all the shares available to it (each, a “Fully
Exercising Investor”) of any other Major Investor’s failure to do likewise. During the ten (10) day period commencing after the Company has given such notice, each Fully Exercising Investor may, by giving notice to the Company,
elect to purchase or acquire, in addition to the number of shares specified above, up to that portion of the New Securities for which Major Investors were entitled to subscribe but that were not subscribed for by the Major Investors which is equal
to the proportion that the Common Stock issued and held, or issuable (directly or indirectly) upon conversion and/or exercise, as applicable, of Preferred Stock and any other Derivative Securities then held, by such Fully Exercising Investor bears
to the Common Stock issued and held, or issuable (directly or indirectly) upon conversion and/or exercise, as applicable, of the Preferred Stock and any other Derivative Securities then held, by all Fully Exercising Investors who wish to purchase
such unsubscribed shares. The closing of any sale pursuant to this Subsection 4.1(b) shall occur within the later of ninety (90) days of the date that the Offer Notice is given and the date of initial sale of New Securities pursuant to
Subsection 4.1(c). 
 (c) If all New Securities referred to in the Offer Notice are not elected to be purchased or acquired as
provided in Subsection 4.1(b), the Company may, during the ninety (90) day period following the expiration of the periods provided in Subsection 4.1(b), offer and sell the remaining unsubscribed portion of such New Securities
to any Person or Persons at a price not less than, and upon terms no more favorable to the offeree than, those specified in the Offer Notice. If the Company does not enter into an agreement for the sale of the

  
 18 

 
New Securities within such period, or if such agreement is not consummated within thirty (30) days of the execution thereof, the right provided hereunder shall be deemed to be revived and
such New Securities shall not be offered unless first reoffered to the Major Investors in accordance with this Subsection 4.1. 

(d) The right of first offer in this Subsection 4.1 shall not be applicable to (i) Exempted Securities (as defined in the
Company’s Certificate of Incorporation); or (ii) shares of Common Stock issued in the IPO. 
 4.2 Termination. The
covenants set forth in Subsection 4.1 shall terminate and be of no further force or effect (i) immediately before the consummation of the IPO, (ii) when the Company first becomes subject to the periodic reporting requirements of
Section 12(g) or 15(d) of the Exchange Act, or (iii) upon a Deemed Liquidation Event, as such term is defined in the Company’s Certificate of Incorporation, whichever event occurs first. 

5. Additional Covenants. 

5.1 Insurance. The Company shall use its commercially reasonable efforts to (i) maintain Directors and Officers liability
insurance and (ii) upon the request of the Board of Directors or the holders of a majority of the Registrable Securities then outstanding, term “key person” insurance on the Chief Executive Officer of the Company, in each case from
financially sound and reputable insurers and in an amount and on terms and conditions satisfactory to the Board of Directors. The Company will use commercially reasonable efforts to cause such insurance policies to be maintained until such time as
the Board of Directors determines that such insurance should be discontinued. The “key person” policy shall name the Company as loss payee and neither policy shall be cancelable by the Company without prior approval by the Board of
Directors, including the Preferred Director. 
 5.2 Employee Agreements. The Company will cause (i) each person now or hereafter
employed by it or by any subsidiary (or engaged by the Company or any subsidiary as a consultant/independent contractor) with access to confidential information and/or trade secrets to enter into a nondisclosure and proprietary rights assignment
agreement and (ii) each Key Employee to enter into a one (1) year noncompetition and nonsolicitation agreement, each in a form acceptable to the Investors. In addition, the Company shall not amend, modify, terminate, waive, or otherwise
alter, in whole or in part, any of the above-referenced agreements or any restricted stock agreement between the Company and any employee, without the consent of the Preferred Director. 

5.3 Employee Stock. Unless otherwise approved by the Board of Directors, including the approval of the Preferred Director, all future
employees and consultants of the Company who purchase, receive options to purchase, or receive awards of shares of the Company’s capital stock after the date hereof shall be required to execute restricted stock or option agreements, as
applicable, providing for (i) vesting of shares over a four (4) year period, with the first twenty-five percent (25%) of such shares vesting following twelve (12) months of continued employment or service, and the remaining
shares vesting in equal quarterly installments over the following thirty-six (36) months, and (ii) a market stand-off provision 

  
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substantially similar to that in Subsection 2.11. In addition, unless otherwise approved by the Board of Directors, including the Preferred Director, the Company shall retain a “right
of first refusal” on employee transfers until the Company’s IPO and shall have the right to repurchase unvested shares at cost upon termination of employment of a holder of restricted stock. 

5.4 Qualified Small Business Stock. The Company shall use commercially reasonable efforts to cause the shares of Preferred Stock issued
pursuant to the Series C Purchase Agreement, as well as any shares into which such shares are converted, within the meaning of Section 1202(f) of the United States Internal Revenue Code of 1986 (as amended, the “Code”), to
constitute “qualified small business stock” as defined in Section 1202(c) of the Code; provided, however, that such requirement shall not be applicable if the Board of Directors of the Company determines, in its
good-faith business judgment, that such qualification is inconsistent with the best interests of the Company. The Company shall submit to its stockholders (including the Investors) and to the Internal Revenue Service any reports that may be required
under Section 1202(d)(1)(C) of the Code and the regulations promulgated thereunder. In addition, within twenty (20) business days after any Investor’s written request therefor, the Company shall, at its option, either (i) deliver
to such Investor a written statement indicating whether (and what portion of) such Investor’s interest in the Company constitutes “qualified small business stock” as defined in Section 1202(c) of the Code or (ii) deliver to
such Investor such factual information in the Company’s possession as is reasonably necessary to enable such Investor to determine whether (and what portion of) such Investor’s interest in the Company constitutes “qualified small
business stock” as defined in Section 1202(c) of the Code. 
 5.5 Matters Requiring Investor Director Approval. So long as
the holders of Series A Preferred Stock, Series B Preferred Stock and Series C Preferred Stock are entitled to elect a Preferred Director, the Company hereby covenants and agrees with the Investors holding shares of Series A Preferred Stock, Series
B Preferred Stock and Series C Preferred Stock that it shall not, nor shall it permit any subsidiary to, without approval of the Board of Directors, which approval must include the affirmative vote of the Preferred Director: 

(a) make any loan or advance to, or own any stock or other securities of, any subsidiary or other corporation, partnership, or other entity
unless it is wholly owned by the Company; 
 (b) make any loan or advance to any Person, including, without limitation, any employee or
director of the Company or any subsidiary, except advances and similar expenditures in the ordinary course of business or under the terms of an employee stock or option plan approved by the Board of Directors, including the Preferred Director; 

(c) guarantee, directly or indirectly, any indebtedness except for trade accounts of the Company or any subsidiary arising in the ordinary
course of business; 
 (d) make any investment inconsistent with any investment policy approved by the Board of Directors; 

  
 20 

 (e) incur any aggregate indebtedness in excess of $250,000 that is not already included in a
budget approved by the Board of Directors, other than trade credit incurred in the ordinary course of business; 
 (f) otherwise enter into
or be a party to any transaction with any director, officer, or employee of the Company or any “associate” (as defined in Rule 12b-2 promulgated under the Exchange Act) of any such Person, except for transactions contemplated by this
Agreement and the Purchase Agreement; transactions resulting in payments to or by the Company in an aggregate amount less than $100,000 per year; or transactions made in the ordinary course of business and pursuant to reasonable requirements of the
Company’s business and upon fair and reasonable terms that are approved by a majority of the Board of Directors; 
 (g) hire,
terminate, or change the compensation of the executive officers, including approving any option grants or stock awards to executive officers; 

(h) change the principal business of the Company, enter new lines of business, or exit the current line of business; 

(i) sell, assign, license, pledge, or encumber material technology or intellectual property, other than licenses granted in the ordinary
course of business; 
 (j) increase the shares of Common Stock reserved for issuance under the Company’s 2012 Stock Incentive Plan or
adopt any other equity incentive plan; or 
 (k) enter into any corporate strategic relationship involving the payment, contribution, or
assignment by the Company or to the Company of money or assets greater than $250,000. 
 5.6 Board Matters. Unless otherwise
determined by the vote of a majority of the directors then in office, the Board of Directors shall meet at least quarterly in accordance with an agreed-upon schedule, unless agreed by a majority of the Board of Directors, including the Preferred
Director. The Company shall reimburse the nonemployee directors for all reasonable out-of-pocket travel expenses incurred (consistent with the Company’s travel policy) in connection with attending meetings of the Board of Directors. The Company
shall cause to be established, as soon as practicable after such request, and will maintain, an audit and compensation committee, each of which shall consist solely of non-management directors. Each non-employee director shall be entitled in such
person’s discretion to be a member of any Board committee. Each committee of the Board shall include the Preferred Director. 
 5.7
Successor Indemnification. If the Company or any of its successors or assignees consolidates with or merges into any other Person and is not the continuing or surviving corporation or entity of such consolidation or merger, then to the extent
necessary, proper provision shall be made so that the successors and assignees of the Company assume the obligations of the Company with respect to indemnification of members of the Board of Directors as in effect immediately before such
transaction, whether such obligations are contained in the Company’s Bylaws, its Certificate of Incorporation, or elsewhere, as the case may be. 

  
 21 

 5.8 Termination of Covenants. The covenants set forth in this Section 5,
except for Subsection 5.7, shall terminate and be of no further force or effect (i) immediately before the consummation of the IPO, (ii) when the Company first becomes subject to the periodic reporting requirements of
Section 12(g) or 15(d) of the Exchange Act, or (iii) upon a Deemed Liquidation Event, as such term is defined in the Company’s Certificate of Incorporation, whichever event occurs first. 

6. Miscellaneous. 
 6.1
Successors and Assigns. The rights under this Agreement may be assigned (but only with all related obligations) by a Holder to a transferee of Registrable Securities that (i) is an Affiliate of a Holder; (ii) is a Holder’s
Immediate Family Member or trust for the benefit of an individual Holder or one or more of such Holder’s Immediate Family Members; or (iii) after such transfer, holds at least 100,000 shares of Registrable Securities (subject to
appropriate adjustment for stock splits, stock dividends, combinations, and other recapitalizations); provided, however, that (x) the Company is, within a reasonable time after such transfer, furnished with written notice of the name and
address of such transferee and the Registrable Securities with respect to which such rights are being transferred; and (y) such transferee agrees in a written instrument delivered to the Company to be bound by and subject to the terms and
conditions of this Agreement, including the provisions of Subsection 2.11. For the purposes of determining the number of shares of Registrable Securities held by a transferee, the holdings of a transferee (1) that is an Affiliate or
stockholder of a Holder; (2) who is a Holder’s Immediate Family Member; or (3) that is a trust for the benefit of an individual Holder or such Holder’s Immediate Family Member shall be aggregated together and with those of the
transferring Holder; provided further that all transferees who would not qualify individually for assignment of rights shall have a single attorney-in-fact for the purpose of exercising any rights, receiving notices, or taking any action under this
Agreement. The terms and conditions of this Agreement inure to the benefit of and are binding upon the respective successors and permitted assignees of the parties. Nothing in this Agreement, express or implied, is intended to confer upon any party
other than the parties hereto or their respective successors and permitted assignees any rights, remedies, obligations or liabilities under or by reason of this Agreement, except as expressly provided herein. Notwithstanding anything to the contrary
in this Subsection 6.1, Comerica Ventures, and its successors and assigns, may transfer and assign its rights under the Agreement (together with all related obligations): (a) to any transferee irrespective of the minimum share
requirement set forth in clause (iii) of this Subsection 6.1; and (b) to any of its Affiliates, partners or stockholders without compliance with the notice and delivery requirements set forth in clauses (x) and (y) in the
proviso at the end of the first sentence of this Subsection 6.1 of the Agreement (but only to the extent such transferee remains bound by the restrictions and obligations of the transferor under the Agreement). 

6.2 Governing Law. This Agreement and any controversy arising out of or relating to this Agreement shall be governed by and construed
in accordance with the internal laws of the Commonwealth of Massachusetts, without regard to conflict of law principles that would result in the application of any law other than the law of the Commonwealth of Massachusetts. 

  
 22 

 6.3 Counterparts. This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (including pdf) or other transmission method and any counterpart so delivered
shall be deemed to have been duly and validly delivered and be valid and effective for all purposes. 
 6.4 Titles and Subtitles. The
titles and subtitles used in this Agreement are for convenience only and are not to be considered in construing or interpreting this Agreement. 

6.5 Notices. All notices and other communications given or made pursuant to this Agreement shall be in writing and shall be deemed
effectively given upon the earlier of actual receipt or: (i) personal delivery to the party to be notified; (ii) when sent, if sent by electronic mail or facsimile during the recipient’s normal business hours, and if not sent during
normal business hours, then on the recipient’s next business day; (iii) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid; or (iv) one (1) business day after the
business day of deposit with a nationally recognized overnight courier, freight prepaid, specifying next-day delivery, with written verification of receipt. All communications shall be sent to the respective parties at their addresses as set forth
on Schedule A hereto, or to the principal office of the Company at 161 First Street, Suite 2C, Cambridge, MA 02142, Attention: Chief Executive Officer, in the case of the Company, or to such email address, facsimile number, or address as
subsequently modified by written notice given in accordance with this Subsection 6.5. If notice is given to the Company, a copy shall also be given to Latham & Watkins LLP, John Hancock Tower, 27th Floor, 200 Clarendon Street, Boston, MA 02116, Attention Peter N. Handrinos, Esq. 

6.6 Amendments and Waivers. Any term of this Agreement may be amended and the observance of any term of this Agreement may be waived
(either generally or in a particular instance, and either retroactively or prospectively) only with the written consent of the Company and the holders of a majority of the Registrable Securities then outstanding; provided that the
Company may in its sole discretion waive compliance with Subsection 2.12(c) (and the Company’s failure to object promptly in writing after notification of a proposed assignment allegedly in violation of Subsection 2.12(c) shall be
deemed to be a waiver); provided further that any provision hereof may be waived by any waiving party on such party’s own behalf, without the consent of any other party. Notwithstanding the foregoing, this Agreement may not be
amended or terminated and the observance of any term hereof may not be waived with respect to any Investor without the written consent of such Investor, unless such amendment, termination, or waiver applies to all Investors in the same fashion (it
being agreed that a waiver of the provisions of Section 4 with respect to a particular transaction shall be deemed to apply to all Investors in the same fashion if such waiver does so by its terms, notwithstanding the fact that certain
Investors may nonetheless, by agreement with the Company, purchase securities in such transaction). The Company shall give prompt notice of any amendment or termination hereof or waiver hereunder to any party hereto that did not consent in writing
to such amendment, termination, or waiver. Any amendment, termination, or waiver effected in accordance with this 

  
 23 

 
Subsection 6.6 shall be binding on all parties hereto, regardless of whether any such party has consented thereto; provided, however, that no such amendment shall be binding
on Nestlé or any of its Affiliates if such amendment (1) is not entered into or approved in writing by Nestlé or such Affiliate (provided that, for the avoidance of doubt, any such entry into or approval in writing that
occurs through the exercise of any right or the enforcement of any obligation arising under Section 4 of the Common Stock Purchase Agreement shall not be deemed for any purpose to constitute an entry into or an approval in writing by
Nestlé or such Affiliate for this purpose) and (2)(i) imposes an obligation on Nestlé or such Affiliate that is unrelated to (x) the subject matter of this Agreement or the Purchase Agreement, or the transactions contemplated
hereby or thereby, (y) Nestlé’s investment in the Company or (z) Nestlé’s ownership of securities of the Company or (ii) imposes any restriction on the conduct by Nestlé or any of its Affiliates of its
business. No waivers of or exceptions to any term, condition, or provision of this Agreement, in any one or more instances, shall be deemed to be or construed as a further or continuing waiver of any such term, condition, or provision. 

6.7 Severability. In case any one or more of the provisions contained in this Agreement is for any reason held to be invalid, illegal
or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other provision of this Agreement, and such invalid, illegal, or unenforceable provision shall be reformed and construed so that it will be valid,
legal, and enforceable to the maximum extent permitted by law. 
 6.8 Aggregation of Stock. All shares of Registrable Securities held
or acquired by Affiliates shall be aggregated together for the purpose of determining the availability of any rights under this Agreement and such Affiliated persons may apportion such rights as among themselves in any manner they deem appropriate.

 6.9 Entire Agreement. This Agreement (including any Schedules hereto) constitutes the full and entire understanding and agreement
among the parties with respect to the subject matter hereof, and any other written or oral agreement relating to the subject matter hereof existing between the parties is expressly canceled. 

6.10 Dispute Resolution. The parties (a) hereby irrevocably and unconditionally submit to the jurisdiction of the state courts of
the Commonwealth of Massachusetts and to the jurisdiction of the United States District Court for the District of Massachusetts for the purpose of any suit, action or other proceeding arising out of or based upon this Agreement, (b) agree not
to commence any suit, action or other proceeding arising out of or based upon this Agreement except in the state courts of the Commonwealth of Massachusetts or the United States District Court for the District of Massachusetts, and (c) hereby
waive, and agree not to assert, by way of motion, as a defense, or otherwise, in any such suit, action or proceeding, any claim that it is not subject personally to the jurisdiction of the above-named courts, that its property is exempt or immune
from attachment or execution, that the suit, action or proceeding is brought in an inconvenient forum, that the venue of the suit, action or proceeding is improper or that this Agreement or the subject matter hereof may not be enforced in or by such
court. 

  
 24 

 WAIVER OF JURY TRIAL: EACH PARTY HEREBY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE
OF ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT, THE OTHER TRANSACTION DOCUMENTS, THE SECURITIES OR THE SUBJECT MATTER HEREOF OR THEREOF. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL-ENCOMPASSING OF ANY AND ALL DISPUTES THAT MAY BE FILED IN
ANY COURT AND THAT RELATE TO THE SUBJECT MATTER OF THIS TRANSACTION, INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS, TORT CLAIMS (INCLUDING NEGLIGENCE), BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY CLAIMS. THIS SECTION HAS BEEN
FULLY DISCUSSED BY EACH OF THE PARTIES HERETO AND THESE PROVISIONS WILL NOT BE SUBJECT TO ANY EXCEPTIONS. EACH PARTY HERETO HEREBY FURTHER WARRANTS AND REPRESENTS THAT SUCH PARTY HAS REVIEWED THIS WAIVER WITH ITS LEGAL COUNSEL, AND THAT SUCH PARTY
KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL RIGHTS FOLLOWING CONSULTATION WITH LEGAL COUNSEL. 
 6.11 Delays or Omissions. No
delay or omission to exercise any right, power, or remedy accruing to any party under this Agreement, upon any breach or default of any other party under this Agreement, shall impair any such right, power, or remedy of such nonbreaching or
nondefaulting party, nor shall it be construed to be a waiver of or acquiescence to any such breach or default, or to any similar breach or default thereafter occurring, nor shall any waiver of any single breach or default be deemed a waiver of any
other breach or default theretofore or thereafter occurring. All remedies, whether under this Agreement or by law or otherwise afforded to any party, shall be cumulative and not alternative. 

6.12 Further Assurances. At any time or from time to time after the date hereof, the parties agree to cooperate with each other, and at
the request of any other party, to execute and deliver any further instruments or documents and to take all such further action as the other party may reasonably request in order to evidence or effectuate the consummation of the transactions
contemplated hereby and to otherwise carry out the intent of the parties hereunder. 
 6.13 Acknowledgment. The Company acknowledges
that each Investor is in the business of venture capital investing and therefore review the business plans and related proprietary information of many enterprises, including enterprises which may have products or services which compete directly or
indirectly with those of the Company. Nothing in this Agreement shall preclude or in any way restrict any Investor from investing or participating in any particular enterprise whether or not such enterprise has products or services which compete
with those of the Company. 
 6.14 Massachusetts Business Trust. A copy of the Agreement and Declaration of Trust of each Investor
affiliated with Fidelity Management & Research Company is on file with the Secretary of State of the Commonwealth of Massachusetts and notice is hereby given that this Agreement is executed on behalf of the trustees of such Investor or any
affiliate thereof as trustees and not individually and that the obligations of this Agreement are not binding on any of the trustees, officers or stockholders of such Investor or any affiliate thereof individually but are binding only upon such
Investor or any affiliate thereof and its assets and property. 

  
 25 

 6.15 Series D-1 Preferred Stock. For all purposes of this Agreement, all outstanding
shares of Series D-1 Preferred Stock shall be deemed to have been converted into Series D Preferred Stock and each reference herein to “Preferred Stock” shall be deemed to refer to and include to such shares. 

[Remainder of Page Intentionally Left Blank] 

  
 26 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Investors’ Rights
Agreement as of the date first written above. 
  

			
	SERES HEALTH, INC.
		
	By:		  

	Name:		Roger J. Pomerantz, M.D.
	Title:		President and Chief Executive Officer

 
			
	INVESTORS:
	
	NESTLÉ HEALTH SCIENCE US HOLDINGS, INC. 
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	FIDELITY SELECT PORTFOLIOS: BIOTECHNOLOGY PORTFOLIO
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	FIDELITY ADVISOR SERIES VII: FIDELITY ADVISOR BIOTECHNOLOGY FUND
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	FIDELITY GROWTH COMPANY COMMINGLED POOL
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	FIDELITY MT. VERNON STREET TRUST: FIDELITY SERIES GROWTH COMPANY FUND
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	FIDELITY MT. VERNON STREET TRUST: FIDELITY GROWTH COMPANY FUND
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	ROCK SPRINGS CAPITAL MASTER FUND LP
	
	 By: Rock Springs GP LLC
	Its: General Partner
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	BLACKROCK HEALTH SCIENCES TRUST
	
	By: BlackRock Advisors, LLC
	Its: Investment Adviser
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	BLACKROCK HEALTH SCIENCES OPPORTUNITIES PORTFOLIO, A SERIES OF BLACKROCK FUNDS
	
	By: BlackRock Advisors, LLC
	Its: Investment Adviser
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	BLACKROCK HEALTH SCIENCES MASTER UNIT TRUST
	
	By: BlackRock Capital Management, Inc.
	Its: Investment Adviser
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	LEERINK HOLDINGS LLC
		
	By:		  

	Name:		
	Title:		Authorized Person

 
			
	INVESTORS:
	
	LEERINK SWANN CO-INVESTMENT FUND, LLC
		
	By:		  

	Name:		
	Title:		Manager

 
			
	INVESTORS:
	
	SOFINNOVA VENTURE PARTNERS IX, L.P.
		
	By:		 Sofinnova Management IX, L.L.C.
 its General
Partner

		
	By:		  

	Name:		Srinivas Akkaraju
	Title:		Managing Member

 
			
	INVESTORS:
	
	T. Rowe Price Health Sciences Fund, Inc.
	TD Mutual Funds – TD Health Sciences Fund
	Valic Company I – Health Sciences Fund
	T. Rowe Price Health Sciences Portfolio
	John Hancock Variable Insurance Trust – Health Sciences Trust
	John Hancock Funds II – Health Sciences Fund,
	 Each fund, severally and not jointly

		
	By:		T. ROWE PRICE ASSOCIATES, INC.,
			Investment Adviser or Subadviser
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	RA CAPITAL HEALTHCARE FUND, LP
		
	By:		  

	Name:		Peter Kolchinsky
	Title:		Manager

 
			
	INVESTORS:
	
	ORBIMED PRIVATE INVESTMENTS V, LP
	
	By: OrbiMed Capital GP V LLC, its General Partner
	
	By: OrbiMed Advisors LLC, is Managing Member
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	FLAGSHIP VENTURES FUND IV, L.P.
	
	By its General Partner
	Flagship Ventures Fund IV General Partner LLC
		
	By:		  

			Manager

 
			
	
	FLAGSHIP VENTURES FUND IV-Rx, L.P.
	
	By its General Partner
	Flagship Ventures Fund IV General Partner LLC
		
	By:		  

			Manager

 
			
	
	FLAGSHIP VENTURES FUND 2007, L.P.
	
	By its General Partner
	Flagship Ventures Fund 2007 General Partner LLC
		
	By:		  

			Manager

 
			
	
	FLAGSHIP VENTURELABS IV LLC
	
	 By: FLAGSHIP VENTURES FUND IV, L.P.

its Authorized Member

	
	 By: FLAGSHIP VENTURES FUND IV GENERAL PARTNER LLC

its General Partner

		
	By:		  

	 Name:
 Title:
		

 
			
	INVESTORS:
	
	 ENSO VENTURES 2 LIMITED
 BY
INTERLOCK DIRECTOR LTD., DIRECTOR

	
	  

	AUTHORIZED SIGNATORY
	
	  

	AUTHORIZED SIGNATORY

 
			
	INVESTORS:
	
	MAYO CLINIC
		
	By:		  

			Name:
			Title:

 
			
	INVESTORS:
	
	 ALEXANDRIA EQUITIES, LLC,
 a
Delaware limited liability company

	
	By: ALEXANDRIA REAL ESTATE EQUITIES, INC., a Maryland corporation, managing member
		
	By:		  

			Name:
			Title:

 
	
	INVESTORS:
	
	  

	Roger J. Pomerantz, M.D.

 
					
	INVESTORS:
	
	FAVREAU 2008 TRUST, DTD 4-10-2008
		
	By:		  

			Name:		Jon Favreau
			Title:		Trustee
		
	By:		  

			Name:		Joya Favreau
			Title:		Trustee

 
	
	INVESTORS:
	
	  

	John Aunins

 
	
	INVESTORS:
	
	  

	David Cook

 
	
	INVESTORS:
	
	  

	Matthew Henn

 SCHEDULE A 

INVESTORS 
 Name and
Address 
  
  

 

			
	 Nestlé Health Science US Holdings, Inc.

900 Long Ridge Road, Building 2
 Stamford, CT 06902

Attention: Andrew Glass, Esq.
 Email:
andrew.glass@us.nestle.com
 F: (480) 379-5510
  

With a copy (which shall not constitute notice) to:
  

Nestlé Health Science S.A.
 Avenue Nestlé, 55

1800 Vevey
 Switzerland

Attention: Claudio Kuoni, Esq.
 Email:
Claudio.Kuoni@nestle.com
 F: 41.21.924.2875
		 OrbiMed Private Investments V, LP
 c/o OrbiMed
Advisors LLC
 Attention: Evan Sotiriou
 601 Lexington Ave.

54th Floor
 New York, NY 10022

		
	 Fidelity Select Portfolios: Biotechnology Portfolio

Brown Brothers Harriman & Co.
 525 Washington Blvd

Jersey City NJ 07310
 Attn: Michael Lerman 15th Floor

Corporate Actions
 Email: michael.lerman@bbh.com

F: (617) 772-2418
		 Leerink Swann Co-Investment Fund, LLC
 1 Federal
Street
 Boston, MA 02110
 Attention: General Counsel

F: (646) 499-7130

		
	 Fidelity Advisor Series VII: Fidelity Advisor

Biotechnology Fund
 State Street Bank & Trust

PO Box 5756
 Boston, Massachusetts 02206

Attn: Bangle & Co fbo Fidelity Advisor Series VII:

Fidelity Advisor Biotechnology Fund
 Email:
SSBCORPACTIONS@StateStreet.com
 F: (617) 988-9110
		 Leerink Holdings LLC
 1 Federal Street

Boston, MA 02110
 Attention: General Counsel

F: (646) 499-7130

		
	 Fidelity Growth Company Commingled Pool
 Brown
Brothers Harriman & Co.
 525 Washington Blvd
 Jersey
City NJ 07310
 Attn: Michael Lerman 15th Floor
 Corporate
Actions
 Email: michael.lerman@bbh.com
 F:
(617) 772-2418
		 T. Rowe Price Health Sciences Fund, Inc.
 T.
Rowe Price Associates, Inc.
 100 East Pratt Street
 Baltimore,
MD 21202
 Attn: Andrew Baek, Vice President and Senior Legal Counsel

Phone: 410-345-2090
 E-mail:
andrew_baek@troweprice.com

			
	 Fidelity Mt. Vernon Street Trust: Fidelity Series

Growth Company Fund
 State Street Bank & Trust

PO Box 5756
 Boston, Massachusetts 02206

Attn: WAVELENGTH + CO Fidelity Mt. Vernon
 Street Trust: Fidelity
Series Growth Company Fund
 Email: SSBCORPACTIONS@StateStreet.com

F: (617) 988-9110
		 VALIC Company I - Health Sciences Fund
 T. Rowe
Price Associates, Inc.
 100 East Pratt Street
 Baltimore, MD
21202
 Attn: Andrew Baek, Vice President and Senior Legal Counsel

Phone: 410-345-2090
 E-mail:
andrew_baek@troweprice.com

		
	 Fidelity Mt. Vernon Street Trust: Fidelity Growth Company Fund

Ball & Co
 C/o Citibank N.A/Custody

IC&D Lock Box
 P.O Box 7247-7057

Philadelphia, P.A 19170-7057
 Account #: 206681

Email: fidelity.tpacd@citi.com
 F: 813-604-1415
		 TD Mutual Funds - TD Health Sciences Fund
 T.
Rowe Price Associates, Inc.
 100 East Pratt Street
 Baltimore,
MD 21202
 Attn: Andrew Baek, Vice President and Senior Legal Counsel

Phone: 410-345-2090
 E-mail:
andrew_baek@troweprice.com

		
	 BlackRock Health Sciences Master Unit Trust
 c/o
BlackRock Advisors, LLC
 Fundamental Equity – Global Opportunities Health & Sciences Team

60 State Street, 19th/20th Floors
 Boston, MA 02109

Attn: Erin Xie, Chian Jiang
 Email: erin.xie@blackrock.com,

chian.jiang@blackrock.com
  

With a copy (which shall not constitute notice) to:
  

c/o BlackRock, Inc.
 Office of the General Counsel

40 East 52nd Street
 New York, NY 10022

Attn: David Maryles and Vincent Taurassi
 Email:
legaltransactions@blackrock.com
		 T. Rowe Price Health Sciences Portfolio
 T. Rowe
Price Associates, Inc.
 100 East Pratt Street
 Baltimore, MD
21202
 Attn: Andrew Baek, Vice President and Senior Legal Counsel

Phone: 410-345-2090
 E-mail:
andrew_baek@troweprice.com

		
	 BlackRock Health Sciences Trust
 c/o BlackRock
Advisors, LLC
 Fundamental Equity – Global Opportunities Health & Sciences Team

60 State Street, 19th/20th Floors
 Boston, MA 02109

Attn: Erin Xie, Chian Jiang
 Email: erin.xie@blackrock.com,

chian.jiang@blackrock.com
		 John Hancock Variable Insurance Trust - Health Sciences Trust

T. Rowe Price Associates, Inc.
 100 East Pratt Street

Baltimore, MD 21202
 Attn: Andrew Baek, Vice President and Senior
Legal Counsel
 Phone: 410-345-2090
 E-mail:
andrew_baek@troweprice.com

			
	With a copy (which shall not constitute notice) to:		
		
	 c/o BlackRock, Inc.
 Office of the General
Counsel
 40 East 52nd Street
 New York, NY 10022

Attn: David Maryles and Vincent Taurassi
 Email:
legaltransactions@blackrock.com
		
		
	 BlackRock Health Sciences Master Unit Trust
 c/o
BlackRock Advisors, LLC
 Fundamental Equity – Global Opportunities Health & Sciences Team

60 State Street, 19th/20th Floors
 Boston, MA 02109

Attn: Erin Xie, Chian Jiang
 Email: erin.xie@blackrock.com,

chian.jiang@blackrock.com
  

With a copy (which shall not constitute notice) to:
  

c/o BlackRock, Inc.
 Office of the General Counsel

40 East 52nd Street
 New York, NY 10022

Attn: David Maryles and Vincent Taurassi
 Email:
legaltransactions@blackrock.com
		 John Hancock Funds II - Health Sciences Fund
 T.
Rowe Price Associates, Inc.
 100 East Pratt Street
 Baltimore,
MD 21202
 Attn: Andrew Baek, Vice President and Senior Legal Counsel

Phone: 410-345-2090
 E-mail:
andrew_baek@troweprice.com

		
	 Sofinnova Venture Partners IX, L.P.
 c/o
Sofinnova Ventures, Inc.
 Attention: Hooman Shahlavi
 3000 Sand
Hill Road, Bldg 4, Suite 250
 Menlo Park, CA 94025
		 RA Capital Healthcare Fund, LP
 c/o RA Capital
Management, LLC,
 Attention: Amanda Daniels
 20 Park Plaza,
Suite 1200
 Boston, MA 02116
 F: (617) 778-2510

		
	 Flagship Ventures Fund IV, L.P.
 c/o Flagship
Ventures
 One Memorial Drive
 Cambridge, MA 02142

F: (617) 868 -1115
		 Rock Springs Capital Master Fund LP
 Attention:
Evans Apeadu
 650 South Exeter Street, Suite 1070
 Baltimore,
MD 21202
 Email: evans@rockspringscapital.com

		
	 Flagship Ventures Fund IV-Rx, L.P.
 c/o Flagship
Ventures
 One Memorial Drive
 Cambridge, MA 02142

F: (617) 868 -1115
		  
 Roger J. Pomerantz, M.D.

XXXXXXXXXXXXXX
 XXXXXXXXXXXXXX

		
	 Flagship Ventures Fund 2007, L.P.

c/o Flagship Ventures
 One Memorial Drive

Cambridge, MA 02142
 F: (617) 868 -1115
		 Favreau 2008 Trust, dtd 4-10-2008

9200 W. Sunset Blvd. PH22
 Los Angeles, CA 90069

F: (310) 858-3947

	

			
	 Flagship VentureLabs IV LLC
 c/o Flagship
Ventures
 One Memorial Drive
 Cambridge, MA 02142

F: (617) 868 -1115
		 David Cook
 XXXXXXXXXXXXXX

XXXXXXXXXXXXXX
 F: (617) 945-0268

		
	 Enso Ventures 2 Limited
 Suite C1

Hirzel Court
 Hirzel Street

St Peter Port
 Guernsey

Channel Islands
 GY1 2NH

F: +44 (0) 1481 755859
		 Matthew Henn
 XXXXXXXXXXXXXX

XXXXXXXXXXXXXX
 F: (617) 945-0268

		
	 Mayo Clinic
 200 First Street SW

Rochester, MN 55905
 F: (507) 538-7802
		 John Aunins
 XXXXXXXXXXXXXX

XXXXXXXXXXXXXX
 F: (617) 945-0268

		
	 Alexandria Equities, LLC
 385 E. Colorado Blvd.
Suite 299
 Pasadena, CA 91101
 F: (626) 578-0770
		
		
	 For purposes of Section 2.1(b), Section 2.2 through Section 2.12, and Section 6 only:

 
 Comerica Ventures Incorporated

1717 Main St.
 5th Floor, MC 6406

Dallas, TX 75201
		

 EXHIBIT D 

FORM OF VOTING AGREEMENT 

 AMENDED AND RESTATED VOTING AGREEMENT 

THIS AMENDED AND RESTATED VOTING AGREEMENT is made and entered into as of this 19th day of December, 2014, by and among Seres Health, Inc., a
Delaware corporation (the “Company”), each holder of the Company’s Series A Preferred Stock, $0.001 par value per share (“Series A Preferred Stock”), Series A-2 Preferred Stock, $0.001 par value per
share (“Series A-2 Preferred Stock”), Series B Preferred Stock, $0.001 par value per share (“Series B Preferred Stock”), Series C Preferred Stock, $0.001 par value per share (“Series C Preferred
Stock”), Series D Preferred Stock, $0.001 par value per share (“Series D Preferred Stock”), and Series D-1 Preferred Stock, $0.001 par value per share (“Series D-1 Preferred Stock” and, together with the
Series A Preferred Stock, Series A-2 Preferred Stock, Series B Preferred Stock, Series C Preferred Stock and Series D Preferred Stock, the “Preferred Stock”) listed on Schedule A (together with any subsequent investors, or
transferees, who become parties hereto as “Investors” pursuant to Subsections 7.1(a) or 7.2 below, the “Investors”) and those certain stockholders of the Company and holders of options to acquire shares of
the capital stock of the Company listed on Schedule B (together with any subsequent stockholders or option holders, or any transferees, who become parties hereto as “Key Holders” pursuant to Subsections 7.1(b) or 7.2
below, the “Key Holders”, and, together collectively with the Investors, the “Stockholders”). 

RECITALS 

A. Concurrently with the execution of this Agreement, the Company and one of the Investors are entering into a Series D Preferred Stock
Purchase Agreement (the “Purchase Agreement”) providing for the sale of shares of Series D Preferred Stock and Series D-1 Preferred Stock. Certain of the Investors (the “Existing Investors”) and the Key Holders are
parties to the Amended and Restated Voting Agreement dated November 24, 2014, by and among the Company and the parties thereto (the “Prior Agreement”). The parties to the Prior Agreement desire to amend and restate that
agreement to provide the Investors with the right, among other rights, to designate the election of certain members of the board of directors of the Company (the “Board”) in accordance with the terms of this Agreement. 

B. The Amended and Restated Certificate of Incorporation of the Company (as may be amended and/or modified from time to time after the
date hereof, the “Restated Certificate”) provides that (a) the holders of record of the shares of the Company’s Series A Preferred Stock, Series A-2 Preferred Stock, Series B Preferred Stock and Series C Preferred Stock
(together, the “ABC Preferred Stock”), exclusively and as a separate class, shall be entitled to elect one (1) director of the Company; (b) the holders of record of the shares of common stock, $0.001 par value per share,
of the Company (the “Common Stock”), exclusively and as a separate class, shall be entitled to elect one (1) director of the Company; and (c) the holders of record of the shares of the Common Stock and of any other class
or series of voting stock (including, without limitation, Series A Preferred Stock, Series A-2 Preferred Stock, Series C Preferred Stock and Series D Preferred Stock) other than the Series D-1 Preferred Stock, exclusively and voting together as a
single class, shall be entitled to elect the balance of the total number of directors of the Company.  
 C. The parties also desire
to enter into this Agreement to set forth their agreements and understandings with respect to how shares of the Company’s capital stock held by them will be voted on, or tendered in connection with, an acquisition of the Company. 

  
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 NOW, THEREFORE, the Company, the Key Holders and the Existing Investors each hereby agree to
amend and restate the Prior Agreement in its entirety as set forth herein, and all of the parties hereto further agree as follows: 
 1.
Voting Provisions Regarding Board of Directors. 
 1.1 Size of the Board. Each Stockholder agrees to vote, or cause to be
voted, all Shares (as defined below) owned by such Stockholder, or over which such Stockholder has voting control, from time to time and at all times, in whatever manner as shall be necessary to ensure that the size of the Board shall be set and
remain at eight (8) directors. For purposes of this Agreement, the term “Shares” shall mean and include any securities of the Company the holders of which are entitled to vote for members of the Board, including without limitation,
all shares of Common Stock, Preferred Stock, by whatever name called, now owned or subsequently acquired by a Stockholder, however acquired, whether through stock splits, stock dividends, reclassifications, recapitalizations, similar events or
otherwise. 
 1.2 Board Composition. Each Stockholder agrees to vote, or cause to be voted, all Shares owned by such Stockholder, or
over which such Stockholder has voting control, from time to time and at all times, in whatever manner as shall be necessary to ensure that at each annual or special meeting of stockholders at which an election of directors is held or pursuant to
any written consent of the stockholders, the following individuals shall be elected to the Board: 
 (a) One individual designated by
Flagship Ventures Fund IV, L.P., Flagship Ventures Fund IV-Rx, L.P. and Flagship Ventures Fund 2007, L.P. (collectively, “Flagship”) who shall be the director elected by the holders of record of the shares of ABC Preferred Stock,
exclusively and as a separate class, pursuant to Article Fourth, Part B, Section 3.2 of the Restated Certificate and known as the “Preferred Stock Director” thereunder, who shall initially be Noubar B. Afeyan, for so long as Flagship
and its Affiliates (as defined below) continue to own beneficially an aggregate of at least twenty-five percent (25%) of the shares of Series B Preferred Stock purchased by them pursuant to the Series B Preferred Stock Purchase Agreement, dated
as of May 23, 2014, by and among the Company and the parties listed on Exhibit A thereto; 
 (b) One individual designated by Flagship
VentureLabs IV LLC (“VentureLabs”), who shall be the director elected by the holders of record of the shares of Common Stock, exclusively and as a separate class, pursuant to Article Fourth, Part B, Section 3.2 of the Restated
Certificate, who shall initially be David A. Berry, for so long as VentureLabs and its Affiliates continue to own beneficially an aggregate of at least 1,250,000 shares of Common Stock (as adjusted for any stock splits, stock dividends,
recapitalizations or the like); 
 (c) (i) One individual designated by Nestlé Health Science US Holdings, Inc.
(“Nestlé”) and who is acceptable to the Board, such approval not to be 

  
 - 2 - 

 
unreasonably withheld, who shall initially be Greg Behar, for so long as Nestlé and its Affiliates continue to own beneficially an aggregate of at least ninety percent (90%) of the
shares of Series D Preferred Stock and Series D-1 Preferred Stock (or Series D Preferred Stock issued upon conversion thereof) purchased by Nestlé pursuant to the Purchase Agreement, and (ii) the Company shall ensure that such individual
is, in the event of the Company’s first underwritten public offering of its Common Stock under the Securities Act of 1933 (as amended, the “Securities Act”), designated by the Company to serve in the class of directors with
terms that expire at the third annual meeting of stockholders held after such offering; 
 (d) The Company’s Chief Executive Officer,
who shall initially be Roger J. Pomerantz (the “CEO Director”), provided that if for any reason the CEO Director shall, after his or her initial election to the Board in his or her capacity as the CEO Director, cease to serve as the
Chief Executive Officer of the Company, each of the Stockholders shall promptly vote their respective Shares (i) to remove the former Chief Executive Officer of the Company from the Board if such person has not resigned as a member of the Board
and (ii) to elect such person’s replacement as Chief Executive Officer of the Company as the new CEO Director; and 
 (e) Four
individuals not otherwise Affiliates of the Company or of the Investors and who are not employees of the Company and who are designated by the holders of shares of ABC Preferred Stock representing at least sixty percent (60%) of the voting
power of the outstanding shares of ABC Preferred Stock, who shall initially be Werner Cautreels, Peter Barton Hutt, Richard N. Kender and Lorence H. Kim. 

To the extent that any of clauses (a) through (e) above shall not be applicable, any member of the Board who would otherwise have
been designated in accordance with the terms thereof shall instead be voted upon by all the stockholders of the Company entitled to vote thereon in accordance with, and pursuant to, the Restated Certificate. 

For purposes of this Agreement, an individual, firm, corporation, partnership, association, limited liability company, trust or any other entity
(collectively, a “Person”) shall be deemed an “Affiliate” of another Person who, directly or indirectly, controls, is controlled by or is under common control with such Person, including, without limitation, any
general partner, managing member, officer or director of such Person or any venture capital or other investment fund now or hereafter existing that is controlled by one or more general partners or managing members of, or shares the same management
company or investment advisor with, such Person. 
 1.3 Failure to Designate a Board Member. In the absence of any designation
from the Persons or groups with the right to designate a director as specified above, the director previously designated by them and then serving shall be reelected if still eligible to serve as provided herein. 

1.4 Removal of Board Members. Each Stockholder also agrees to vote, or cause to be voted, all Shares owned by such Stockholder, or over
which such Stockholder has voting control, from time to time and at all times, in whatever manner as shall be necessary to ensure that: 

(a) no director elected pursuant to Subsections 1.2 or 1.3 of this Agreement may be removed from office other than for
cause unless (i) such removal is directed or approved by the affirmative vote of the Person entitled under Subsection 1.2 to designate that director or (ii) the Person(s) originally entitled to designate or approve such
director or occupy such Board seat pursuant to Subsection 1.2 is no longer so entitled to designate or approve such director or occupy such Board seat; 

  
 - 3 - 

 (b) any vacancies created by the resignation, removal or death of a director elected pursuant to
Subsections 1.2 or 1.3 shall be filled pursuant to the provisions of this Section 1; and 
 (c) upon the
request of any party entitled to designate a director as provided in Subsection 1.2(a), Subsection 1.2(b) or Subsection 1.2(c) to remove such director, such director shall be removed. 

All Stockholders agree to execute any written consents required to perform the obligations of this Agreement, and the Company agrees at the request of any
party entitled to designate directors to call a special meeting of stockholders for the purpose of electing directors. 
 1.5 No
Liability for Election of Recommended Directors. No Stockholder, nor any Affiliate of any Stockholder, shall have any liability as a result of designating a person for election as a director for any act or omission by such designated person in
his or her capacity as a director of the Company, nor shall any Stockholder have any liability as a result of voting for any such designee in accordance with the provisions of this Agreement. 

2. Vote to Increase Authorized Common Stock. Each Stockholder agrees to vote or cause to be voted all Shares owned by such Stockholder,
or over which such Stockholder has voting control, from time to time and at all times, in whatever manner as shall be necessary to increase the number of authorized shares of Common Stock from time to time to ensure that there will be sufficient
shares of Common Stock available for conversion of all of the shares of Preferred Stock outstanding at any given time. 
 3. Drag-Along
Right. 
 3.1 Definitions. A “Sale of the Company” shall mean either: (a) a transaction or series of
related transactions in which a Person, or a group of related Persons, other than Affiliates of stockholders of the Company, acquires from stockholders of the Company shares representing more than fifty percent (50%) of the outstanding voting
power of the Company (a “Stock Sale”); or (b) a transaction that qualifies as a “Deemed Liquidation Event” as defined in the Restated Certificate (a “Deemed Liquidation Event”). 

  
 - 4 - 

 3.2 Actions to be Taken. In the event that (i) the holders of shares of Preferred
Stock representing a majority of the voting power of the outstanding shares of Preferred Stock (the “Selling Investors”) and (ii) the Board (collectively, the “Electing Holders”) approve a Sale of the Company
in writing, specifying that this Section 3 shall apply to such transaction, then each Stockholder hereby agrees: 
 (a) if such
transaction requires stockholder approval, with respect to all Shares that such Stockholder owns or over which such Stockholder otherwise exercises voting power, to vote (in person, by proxy or by action by written consent, as applicable) all Shares
in favor of, and adopt, such Sale of the Company (together with any related amendment to the Restated Certificate required in order to implement such Sale of the Company) and to vote in opposition to any and all other proposals that could reasonably
be expected to delay or impair the ability of the Company to consummate such Sale of the Company; 
 (b) if such transaction is a Stock
Sale, to sell the same proportion of shares of capital stock of the Company beneficially held by such Stockholder as is being sold by the Selling Investors to the Person to whom the Selling Investors propose to sell their Shares, and, except as
permitted in Subsection 3.3 below, on the same terms and conditions as the Selling Investors; 
 (c) to execute and deliver all
related documentation and take such other action in support of the Sale of the Company as shall reasonably be requested by the Company or the Selling Investors in order to carry out the terms and provision of this Section 3, including
without limitation executing and delivering instruments of conveyance and transfer, and any purchase agreement, merger agreement, indemnity agreement, escrow agreement, consent, waiver, governmental filing, share certificates duly endorsed for
transfer (free and clear of impermissible liens, claims and encumbrances) and any similar or related documents; 
 (d) not to deposit, and
to cause their Affiliates not to deposit, except as provided in this Agreement, any Shares of the Company owned by such party or Affiliate in a voting trust or subject any Shares to any arrangement or agreement with respect to the voting of such
Shares, unless specifically requested to do so by the acquiror in connection with the Sale of the Company; 
 (e) to refrain from
exercising any dissenters’ rights or rights of appraisal under applicable law at any time with respect to such Sale of the Company; and 

(f) if the consideration to be paid in exchange for the Shares pursuant to this Section 3 includes any securities and due receipt
thereof by any Stockholder would require under applicable law (x) the registration or qualification of such securities or of any person as a broker or dealer or agent with respect to such securities or (y) the provision to any Stockholder
of any information other than such information as a prudent issuer would generally furnish in an offering made solely to “accredited investors” as defined in Regulation D promulgated under the Securities Act, the Company may cause to be
paid to any such Stockholder in lieu thereof, against surrender of the Shares which would have otherwise been sold by such Stockholder, an amount in cash equal to the fair value (as determined in good faith by the Company) of the securities which
such Stockholder would otherwise receive as of the date of the issuance of such securities in exchange for the Shares. 

  
 - 5 - 

 3.3 Exceptions. Notwithstanding the foregoing, a Stockholder will not be required to
comply with Subsection 3.2 above in connection with any proposed Sale of the Company (the “Proposed Sale”) unless: 

(a) any representations and warranties to be made by such Stockholder in connection with the Proposed Sale are limited to representations and
warranties related to authority, ownership and the ability to convey title to such Shares, including but not limited to representations and warranties that (i) the Stockholder holds all right, title and interest in and to the Shares such
Stockholder purports to hold, free and clear of all liens and encumbrances, (ii) the obligations of the Stockholder in connection with the transaction have been duly authorized, if applicable, (iii) the documents to be entered into by the
Stockholder have been duly executed by the Stockholder and delivered to the acquirer and are enforceable against the Stockholder in accordance with their respective terms and (iv) neither the execution and delivery of documents to be entered
into in connection with the transaction, nor the performance of the Stockholder’s obligations thereunder, will cause a breach or violation of the terms of any agreement, law or judgment, order or decree of any court or governmental agency; 

(b) the Stockholder shall not be liable for the inaccuracy of any representation or warranty made by any other Person in connection with the
Proposed Sale, other than the Company (except to the extent that funds may be paid out of an escrow established to cover breach of representations, warranties and covenants of the Company as well as breach by any stockholder of any of identical
representations, warranties and covenants provided by all stockholders); 
 (c) the liability for indemnification, if any, of such
Stockholder in the Proposed Sale and for the inaccuracy of any representations and warranties made by the Company or its Stockholders in connection with such Proposed Sale, is several and not joint with any other Person (except to the extent that
funds may be paid out of an escrow established to cover breach of representations, warranties and covenants of the Company as well as breach by any stockholder of any of identical representations, warranties and covenants provided by all
stockholders), and, subject to the provisions of the Restated Certificate related to the allocation of the escrow, is pro rata in proportion to, and does not exceed, the amount of consideration paid to such Stockholder in connection with such
Proposed Sale (in accordance with the provisions of the Restated Certificate); 
 (d) upon the consummation of the Proposed Sale,
(i) each holder of each class or series of the Company’s stock will receive the same form of consideration for their shares of such class or series as is received by other holders in respect of their shares of such same class or series of
stock, (ii) each holder of a series of Preferred Stock will receive the same amount of consideration per share of such series of Preferred Stock as is received by other holders in respect of their shares of such same series, (iii) each
holder of Common Stock will receive the same amount of consideration per share of Common Stock as is received by other holders in respect of their shares of Common Stock, and (iv) unless the holders of shares of ABC Preferred Stock representing
at least sixty percent (60%) of voting power of the ABC Preferred Stock elect to receive a lesser amount by written notice given to the Company at least ten (10) days prior to the effective date of any such Proposed Sale, the aggregate
consideration receivable by all holders of the Preferred Stock and Common Stock shall be allocated among the holders of Preferred Stock and Common Stock on the basis of the relative liquidation preferences to which the holders of each respective
series of Preferred Stock and the holders of Common Stock are entitled in a Deemed Liquidation Event (assuming for this purpose that the Proposed Sale is a Deemed Liquidation Event) in accordance with the Company’s Certificate of Incorporation
in 

  
 - 6 - 

 
effect immediately prior to the Proposed Sale; provided, however, that, notwithstanding the foregoing, if the consideration to be paid in exchange for the Key Holder Shares or
Investor Shares, as applicable, pursuant to this Subsection 3.3(d) includes any securities and due receipt thereof by any Key Holder or Investor would require under applicable law (x) the registration or qualification of such securities
or of any person as a broker or dealer or agent with respect to such securities or (y) the provision to any Key Holder or Investor of any information other than such information as a prudent issuer would generally furnish in an offering made
solely to “accredited investors” as defined in Regulation D promulgated under the Securities Act, the Company may cause to be paid to any such Key Holder or Investor in lieu thereof, against surrender of the Key Holder Shares or Investor
Shares, as applicable, which would have otherwise been sold by such Key Holder or Investor, an amount in cash equal to the fair value (as determined in good faith by the Company) of the securities which such Key Holder or Investor would otherwise
receive as of the date of the issuance of such securities in exchange for the Key Holder Shares or Investor Shares, as applicable; and 

(e) subject to clause (d) above, requiring the same form of consideration to be available to the holders of any single class or series
of capital stock, if any holders of any single class or series of capital stock of the Company are given an option as to the form and amount of consideration to be received as a result of the Proposed Sale, all holders of such class or series of
capital stock will be given the same option; provided, however, that nothing in this Subsection 3.3(e) shall entitle any holder to receive any form of consideration that such holder would be ineligible to receive as a result of
such holder’s failure to satisfy any condition, requirement or limitation that is generally applicable to the Company’s stockholders. 

3.4 Restrictions on Sales of Control of the Company. No Stockholder shall be a party to any Stock Sale unless all holders of Preferred
Stock are allowed to participate in such transaction and the consideration received pursuant to such transaction is allocated among the parties thereto in the manner specified in the Company’s Certificate of Incorporation in effect immediately
prior to the Stock Sale (as if such transaction were a Deemed Liquidation Event), unless the holders of Preferred Stock representing a majority of the voting power of the Preferred Stock elect otherwise by written notice given to the Company at
least ten (10) days prior to the effective date of any such transaction or series of related transactions. 
 4. Remedies. 

4.1 Covenants of the Company. The Company agrees to use its best efforts, within the requirements of applicable law, to ensure that the
rights granted under this Agreement are effective and that the parties enjoy the benefits of this Agreement. Such actions include, without limitation, the use of the Company’s best efforts to cause the nomination and election of the directors
as provided in this Agreement. 
 4.2 Irrevocable Proxy and Power of Attorney. Each party to this Agreement (other than an Investor
that, together with its Affiliates, originally purchased at least 400,000 shares of Series C Preferred Stock (as adjusted for any stock split, stock dividend, combination, or other recapitalization or reclassification) purchased from the Company
pursuant to the Series C Preferred Stock Purchase Agreement, dated as of November 24, 2014, by and among the Company and the other parties named therein) hereby constitutes and appoints as the proxies of

  
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the party and hereby grants a power of attorney to the President of the Company, and a designee of the Selling Investors, and each of them, with full power of substitution, with respect to the
matters set forth herein, including without limitation, election of persons as members of the Board in accordance with Section 1 hereto, votes to increase authorized shares pursuant to Section 2 hereof and votes regarding any
Sale of the Company pursuant to Section 3 hereof, and hereby authorizes each of them to represent and to vote, if and only if the party (i) fails to vote or (ii) attempts to vote (whether by proxy, in person or by written
consent), in a manner which is inconsistent with the terms of this Agreement, all of such party’s Shares in favor of the election of persons as members of the Board determined pursuant to and in accordance with the terms and provisions of this
Agreement or the increase of authorized shares or approval of any Sale of the Company pursuant to and in accordance with the terms and provisions of Sections 2 and 3, respectively, of this Agreement or to take any action necessary to
effect Sections 2 and 3, respectively, of this Agreement. Each of the proxy and power of attorney granted pursuant to the immediately preceding sentence is given in consideration of the agreements and covenants of the Company and the
parties in connection with the transactions contemplated by this Agreement and, as such, each is coupled with an interest and shall be irrevocable unless and until this Agreement terminates or expires pursuant to Section 6 hereof. Each
party hereto hereby revokes any and all previous proxies or powers of attorney with respect to the Shares and shall not hereafter, unless and until this Agreement terminates or expires pursuant to Section 6 hereof, purport to grant any
other proxy or power of attorney with respect to any of the Shares, deposit any of the Shares into a voting trust or enter into any agreement (other than this Agreement), arrangement or understanding with any person, directly or indirectly, to vote,
grant any proxy or give instructions with respect to the voting of any of the Shares, in each case, with respect to any of the matters set forth herein. 

4.3 Specific Enforcement. Each party acknowledges and agrees that each party hereto will be irreparably damaged in the event any of the
provisions of this Agreement are not performed by the parties in accordance with their specific terms or are otherwise breached. Accordingly, it is agreed that each of the Company and any Stockholder shall be entitled to an injunction to prevent
breaches of this Agreement, and to specific enforcement of this Agreement and its terms and provisions in any action instituted in any court of the United States or any state having subject matter jurisdiction. 

4.4 Remedies Cumulative. All remedies, either under this Agreement or by law or otherwise afforded to any party, shall be cumulative
and not alternative. 
 5. Bad Actor Matters. 

5.1 Representation. Each Stockholder that is (or, as a result of its purchase of shares of Series D Preferred Stock or Series D-1 Preferred Stock under the Purchase Agreement, will become) a Person described in the first paragraph of Rule 506(d)(1) promulgated under the Securities Act (a “Covered Person”),
hereby represents that none of the “Bad Actor” disqualifying events described in Rule 506(d)(1)(i) to (viii) promulgated under the Securities Act (a “Disqualification Event”) is applicable to such Stockholder or any
of its Rule 506(d) Related Parties, except, if applicable, for a Disqualification Event as to which Rule 506(d)(2)(ii) or (iii) or (d)(3) is applicable. For purposes of this Agreement, “Rule 506(d) Related Party” shall mean a person
or entity that is a beneficial owner of such Stockholder’s securities for purposes of Rule 506(d) of the Securities Act. 

  
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 5.2 Covenant. Each Stockholder that is a Covered Person hereby agrees that it shall notify
the Company promptly in writing in the event a Disqualification Event becomes applicable to such Stockholder (or any of its Rule 506(d) Related Parties), except, if applicable, for a Disqualification Event as to which Rule 506(d)(2)(ii) or
(iii) or (d)(3) is applicable. 
 6. Term. This Agreement shall be effective as of the date hereof and shall continue in effect
until and shall terminate upon the earliest to occur of (a) the consummation of the Company’s first underwritten public offering of its Common Stock (other than a registration statement relating either to the sale of securities to
employees of the Company pursuant to its stock option, stock purchase or similar plan or an SEC Rule 145 transaction); (b) the consummation of a Sale of the Company and distribution of proceeds to or escrow for the benefit of the Stockholders
in accordance with the Restated Certificate, provided that the provisions of Section 3 hereof will continue after the closing of any Sale of the Company to the extent necessary to enforce the provisions of Section 3 with
respect to such Sale of the Company; and (c) termination of this Agreement in accordance with Subsection 7.8 below. 
 7.
Miscellaneous. 
 7.1 Additional Parties. 

(a) Notwithstanding anything to the contrary contained herein, if the Company issues additional shares of Preferred Stock after the date
hereof, as a condition to the issuance of such shares the Company shall require that any purchaser of shares of Preferred Stock become a party to this Agreement by executing and delivering (i) the Adoption Agreement attached to this Agreement
as Exhibit A, or (ii) a counterpart signature page hereto agreeing to be bound by and subject to the terms of this Agreement as an Investor and Stockholder hereunder. In either event, each such person shall thereafter be deemed an
Investor and Stockholder for all purposes under this Agreement. 
 (b) In the event that after the date of this Agreement, the Company
enters into an agreement with any Person to issue shares of capital stock to such Person (other than to a purchaser of Preferred Stock described in Subsection 7.1(a) above), following which such Person shall hold Shares constituting one
percent (1%) or more of the Company’s then outstanding capital stock (treating for this purpose all shares of Common Stock issuable upon exercise of or conversion of outstanding options, warrants or convertible securities, as if exercised
and/or converted or exchanged), then the Company shall cause such Person, as a condition precedent to entering into such agreement, to become a party to this Agreement by executing an Adoption Agreement in the form attached hereto as Exhibit
A, agreeing to be bound by and subject to the terms of this Agreement as a Key Holder and Stockholder, and thereafter such person shall be deemed a Key Holder and Stockholder for all purposes under this Agreement. 

7.2 Transfers. Each transferee or assignee of any Shares subject to this Agreement shall continue to be subject to the terms hereof,
and, as a condition precedent to the 

  
 - 9 - 

 
Company’s recognizing such transfer, each transferee or assignee shall agree in writing to be subject to each of the terms of this Agreement by executing and delivering an Adoption Agreement
substantially in the form attached hereto as Exhibit A. Upon the execution and delivery of an Adoption Agreement by any transferee, such transferee shall be deemed to be a party hereto as if such transferee were the transferor and such
transferee’s signature appeared on the signature pages of this Agreement and shall be deemed to be an Investor and Stockholder, or Key Holder and Stockholder, as applicable. The Company shall not permit the transfer of the Shares subject to
this Agreement on its books or issue a new certificate representing any such Shares unless and until such transferee shall have complied with the terms of this Subsection 7.2. Each certificate representing the Shares subject to this Agreement
if issued on or after the date of this Agreement shall be endorsed by the Company with the legend set forth in Subsection 7.12. 

7.3 Successors and Assigns. The terms and conditions of this Agreement shall inure to the benefit of and be binding upon the respective
successors and assigns of the parties. Nothing in this Agreement, express or implied, is intended to confer upon any party other than the parties hereto or their respective successors and assigns any rights, remedies, obligations, or liabilities
under or by reason of this Agreement, except as expressly provided in this Agreement. 
 7.4 Governing Law. This Agreement and any
controversy arising out of or relating to this Agreement shall be governed by and construed in accordance with the internal laws of the State of Delaware, without regard to conflict of law principles that would result in the application of any law
other than the law of the State of Delaware. 
 7.5 Counterparts. This Agreement may be executed in two or more counterparts, each of
which shall be deemed an original, but all of which together shall constitute one and the same instrument. Counterparts may be delivered via facsimile, electronic mail (including pdf) or other transmission method and any counterpart so delivered
shall be deemed to have been duly and validly delivered and be valid and effective for all purposes. 
 7.6 Titles and Subtitles. The
titles and subtitles used in this Agreement are used for convenience only and are not to be considered in construing or interpreting this Agreement. 

7.7 Notices. All notices and other communications given or made pursuant to this Agreement shall be in writing and shall be deemed
effectively given upon the earlier of actual receipt or: (a) personal delivery to the party to be notified, (b) when sent, if sent by electronic mail or facsimile during normal business hours of the recipient, and if not sent during normal
business hours, then on the recipient’s next business day, (c) five (5) days after having been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one (1) business day after the business
day of deposit with a nationally recognized overnight courier, freight prepaid, specifying next business day delivery, with written verification of receipt. All communications shall be sent to the respective parties at their address as set forth on
Schedule A or Schedule B hereto, or to such email address, facsimile number or address as subsequently modified by written notice given in accordance with this Subsection 7.7. If notice is given to the Company, it shall be sent
to 161 First Street, Suite 2C, Cambridge, MA 02142, Attention: Chief Executive Officer, and a copy shall also be sent to Latham & Watkins LLP, John Hancock Tower, 27th Floor, 20 Clarendon Street, Boston, MA 02116, Attention: Peter N.
Handrinos, Esq. 

  
 - 10 - 

 7.8 Consent Required to Amend, Terminate or Waive. This Agreement may be amended or
terminated and the observance of any term hereof may be waived (either generally or in a particular instance and either retroactively or prospectively) only by a written instrument executed by (a) the Company; (b) the Key Holders holding a
majority of the Shares then held by the Key Holders who are then providing services to the Company as officers, employees or consultants; and (c) the holders of a majority of the shares of Common Stock issued or issuable upon conversion of the
shares of Preferred Stock held by the Investors (voting as a single class and on an as-converted basis). Notwithstanding the foregoing: 

(a) this Agreement may not be amended or terminated and the observance of any term of this Agreement may not be waived with respect to any
Investor or Key Holder without the written consent of such Investor or Key Holder unless such amendment, termination or waiver applies to all Investors or Key Holders, as the case may be, in the same fashion; 

(b) the consent of the Key Holders shall not be required for any amendment or waiver if such amendment or waiver either (A) is not
directly applicable to the rights of the Key Holders hereunder or (B) does not adversely affect the rights of the Key Holders in a manner that is different than the effect on the rights of the other parties hereto; 

(c) Schedules A and B hereto may be amended by the Company from time to time, without the consent of the other parties hereto,
to add information regarding additional Investors and Key Holders in accordance with Subsections 7.1 and 7.2 hereof; 
 (d)
any provision hereof may be waived by the waiving party on such party’s own behalf, without the consent of any other party; 
 (e)
neither Subsection 1.2(a) of this Agreement nor this Subsection 7.8(e) shall be amended or waived without the written consent of Flagship so long as it is entitled to designate a director under Subsection 1.2(a); 

(f) neither Subsection 1.2(b) of this Agreement nor this Subsection 7.8(f) shall be amended or waived without the written
consent of VentureLabs so long as it is entitled to designate a director under Subsection 1.2(b); and 
 (g) neither Subsection
1.2(c) of this Agreement nor this Subsection 7.8(g) shall be amended or waived without the written consent of Nestlé so long as it is entitled to designate a director under Subsection 1.2(c). 

The Company shall give prompt written notice of any amendment, termination or waiver hereunder to any party that did not consent in writing thereto. Any
amendment, termination or waiver effected in accordance with this Subsection 7.8 shall be binding on each party and all of such party’s successors and permitted assigns, whether or not any such party, successor or assignee entered into
or approved such amendment, termination or waiver; provided, however, that no amendment to this Agreement shall be binding on Nestlé or any of its Affiliates if such amendment (1) is not entered into or approved in writing
by Nestlé or such Affiliate (provided that, for the avoidance of doubt, any such entry into or approval in writing that occurs through the exercise of any right or the enforcement of any obligation arising under Section 4 of that

  
 - 11 - 

 
certain Stock Purchase Agreement dated as of December 19, 2014, by and between Flagship VentureLabs IV LLC and Nestlé shall not be deemed for any purpose to constitute an entry into
or an approval in writing by Nestlé or such Affiliate for this purpose) and (2)(i) imposes an obligation on Nestlé or such Affiliate that is unrelated to (x) the subject matter of this Agreement or the Purchase Agreement, or
the transactions contemplated hereby or thereby, (y) Nestlé’s investment in the Company or (z) Nestlé’s ownership of securities of the Company or (ii) imposes any restriction on the conduct by Nestlé or
any of its Affiliates of its business. For purposes of this Subsection 7.8, the requirement of a written instrument may be satisfied in the form of an action by written consent of the Stockholders circulated by the Company and executed by the
Stockholder parties specified, whether or not such action by written consent makes explicit reference to the terms of this Agreement. 
 7.9
Delays or Omissions. No delay or omission to exercise any right, power or remedy accruing to any party under this Agreement, upon any breach or default of any other party under this Agreement, shall impair any such right, power or remedy of
such non-breaching or non-defaulting party nor shall it be construed to be a waiver of any such breach or default, or an acquiescence therein, or of or in any similar breach or default thereafter occurring; nor shall any waiver of any single breach
or default be deemed a waiver of any other breach or default previously or thereafter occurring. Any waiver, permit, consent or approval of any kind or character on the part of any party of any breach or default under this Agreement, or any waiver
on the part of any party of any provisions or conditions of this Agreement, must be in writing and shall be effective only to the extent specifically set forth in such writing. All remedies, either under this Agreement or by law or otherwise
afforded to any party, shall be cumulative and not alternative. 
 7.10 Severability. The invalidity or unenforceability of any
provision hereof shall in no way affect the validity or enforceability of any other provision. 
 7.11 Entire Agreement. This
Agreement (including the Schedules and Exhibits hereto) and the Restated Certificate constitute the full and entire understanding and agreement between the parties with respect to the subject matter hereof, and any other written or oral agreement
relating to the subject matter hereof existing between the parties is expressly canceled. 
 7.12 Legend on Share Certificates. Each
certificate representing any Shares issued after the date hereof shall be endorsed by the Company with a legend reading substantially as follows: 

“THE SHARES EVIDENCED HEREBY ARE SUBJECT TO A VOTING AGREEMENT, AS MAY BE AMENDED FROM TIME TO TIME, (A COPY OF WHICH MAY BE OBTAINED UPON
WRITTEN REQUEST FROM THE COMPANY), AND BY ACCEPTING ANY INTEREST IN SUCH SHARES THE PERSON ACCEPTING SUCH INTEREST SHALL BE DEEMED TO AGREE TO AND SHALL BECOME BOUND BY ALL THE PROVISIONS OF THAT VOTING AGREEMENT, INCLUDING CERTAIN RESTRICTIONS ON
TRANSFER AND OWNERSHIP SET FORTH THEREIN.” 

  
 - 12 - 

 The Company, by its execution of this Agreement, agrees that it will cause the certificates evidencing the Shares
issued after the date hereof to bear the legend required by this Subsection 7.12 of this Agreement, and it shall supply, free of charge, a copy of this Agreement to any holder of a certificate evidencing Shares upon written request from such
holder to the Company at its principal office. The parties to this Agreement do hereby agree that the failure to cause the certificates evidencing the Shares to bear the legend required by this Subsection 7.12 herein and/or the failure of the
Company to supply, free of charge, a copy of this Agreement as provided hereunder shall not affect the validity or enforcement of this Agreement. 

7.13 Stock Splits, Stock Dividends, etc. In the event of any issuance of Shares of the Company’s voting securities hereafter to
any of the Stockholders (including, without limitation, in connection with any stock split, stock dividend, recapitalization, reorganization, or the like), such Shares shall become subject to this Agreement and shall be endorsed with the legend set
forth in Subsection 7.12. 
 7.14 Manner of Voting. The voting of Shares pursuant to this Agreement may be effected in person,
by proxy, by written consent or in any other manner permitted by applicable law. For the avoidance of doubt, voting of the Shares pursuant to the Agreement need not make explicit reference to the terms of this Agreement. 

7.15 Further Assurances. At any time or from time to time after the date hereof, the parties agree to cooperate with each other, and at
the request of any other party, to execute and deliver any further instruments or documents and to take all such further action as the other party may reasonably request in order to evidence or effectuate the consummation of the transactions
contemplated hereby and to otherwise carry out the intent of the parties hereunder. 
 7.16 Dispute Resolution. The parties
(a) hereby irrevocably and unconditionally submit to the jurisdiction of the state courts of the Commonwealth of Massachusetts and to the jurisdiction of the United States District Court for the District of Massachusetts for the purpose of any
suit, action or other proceeding arising out of or based upon this Agreement, (b) agree not to commence any suit, action or other proceeding arising out of or based upon this Agreement except in the state courts of the Commonwealth of
Massachusetts or the United States District Court for the District of Massachusetts, and (c) hereby waive, and agree not to assert, by way of motion, as a defense, or otherwise, in any such suit, action or proceeding, any claim that it is not
subject personally to the jurisdiction of the above-named courts, that its property is exempt or immune from attachment or execution, that the suit, action or proceeding is brought in an inconvenient forum, that the venue of the suit, action or
proceeding is improper or that this Agreement or the subject matter hereof may not be enforced in or by such court. 
 WAIVER OF JURY TRIAL: EACH PARTY
HEREBY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT, THE OTHER TRANSACTION DOCUMENTS, THE SECURITIES OR THE SUBJECT MATTER HEREOF OR THEREOF. THE SCOPE OF THIS WAIVER IS INTENDED TO BE
ALL-ENCOMPASSING OF ANY AND ALL DISPUTES THAT MAY BE FILED IN ANY COURT AND THAT RELATE TO THE SUBJECT MATTER OF THIS 

  
 - 13 - 

 
TRANSACTION, INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS, TORT CLAIMS (INCLUDING NEGLIGENCE), BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY CLAIMS. THIS SECTION HAS BEEN FULLY
DISCUSSED BY EACH OF THE PARTIES HERETO AND THESE PROVISIONS WILL NOT BE SUBJECT TO ANY EXCEPTIONS. EACH PARTY HERETO HEREBY FURTHER WARRANTS AND REPRESENTS THAT SUCH PARTY HAS REVIEWED THIS WAIVER WITH ITS LEGAL COUNSEL, AND THAT SUCH PARTY
KNOWINGLY AND VOLUNTARILY WAIVES ITS JURY TRIAL RIGHTS FOLLOWING CONSULTATION WITH LEGAL COUNSEL 
 7.17 Aggregation of Stock. All
Shares held or acquired by a Stockholder and/or its Affiliates shall be aggregated together for the purpose of determining the availability of any rights under this Agreement, and such Affiliated persons may apportion such rights as among themselves
in any manner they deem appropriate. 
 7.18 Spousal Consent. If any individual Stockholder is a resident of Arizona, California,
Idaho, Louisiana, Nevada, New Mexico, Texas, Washington, or Wisconsin, or the Commonwealth of Puerto Rico and is married on the date of this Agreement, such Stockholder’s spouse shall execute and deliver to the Company a consent of spouse in
the form of Exhibit B hereto (“Consent of Spouse”), effective on the date hereof. Notwithstanding the execution and delivery thereof, such consent shall not be deemed to confer or convey to the spouse any rights in such
Stockholder’s Shares that do not otherwise exist by operation of law or the agreement of the parties. If any individual Stockholder should marry or remarry subsequent to the date of this Agreement, such Stockholder shall within thirty
(30) days thereafter obtain his/her new spouse’s acknowledgement of and consent to the existence and binding effect of all restrictions contained in this Agreement by causing such spouse to execute and deliver a Consent of Spouse
acknowledging the restrictions and obligations contained in this Agreement and agreeing and consenting to the same. 
 7.19 Massachusetts
Business Trust. A copy of the Agreement and Declaration of Trust of each Investor affiliated with Fidelity Management & Research Company is on file with the Secretary of State of the Commonwealth of Massachusetts and notice is hereby
given that this Agreement is executed on behalf of the trustees of such Investor or any affiliate thereof as trustees and not individually and that the obligations of this Agreement are not binding on any of the trustees, officers or stockholders of
such Investor or any affiliate thereof individually but are binding only upon such Investor or any affiliate thereof and its assets and property. 

[Signature Page Follows] 

  
 - 14 - 

 IN WITNESS WHEREOF, the parties have executed this Amended and Restated Voting Agreement as of
the date first written above. 
  

			
			COMPANY:
	
	SERES HEALTH, INC.
		
	By:		  

		
	Name:		Roger J. Pomerantz, M.D.
		
	Title:		President and Chief Executive Officer

 
			
	INVESTORS:
	
	NESTLÉ HEALTH SCIENCE US HOLDINGS, INC.
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	FIDELITY SELECT PORTFOLIOS: BIOTECHNOLOGY PORTFOLIO
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	FIDELITY ADVISOR SERIES VII: FIDELITY ADVISOR BIOTECHNOLOGY FUND
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	FIDELITY GROWTH COMPANY COMMINGLED POOL
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	FIDELITY MT. VERNON STREET TRUST: FIDELITY SERIES GROWTH COMPANY FUND
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	FIDELITY MT. VERNON STREET TRUST: FIDELITY GROWTH COMPANY FUND
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	ROCK SPRINGS CAPITAL MASTER FUND LP
	
	By: Rock Springs GP LLC
	Its: General Partner
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	BLACKROCK HEALTH SCIENCES TRUST
	
	By: BlackRock Advisors, LLC
	Its: Investment Adviser
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	BLACKROCK HEALTH SCIENCES OPPORTUNITIES PORTFOLIO, A SERIES OF BLACKROCK FUNDS
	
	By: BlackRock Advisors, LLC
	Its: Investment Adviser
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	BLACKROCK HEALTH SCIENCES MASTER UNIT TRUST
	
	By: BlackRock Capital Management, Inc.
	Its: Investment Adviser
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	LEERINK HOLDINGS LLC
		
	By:		  

	Name:		
	Title:		Authorized Person

 
			
	INVESTORS:
	
	LEERINK SWANN CO-INVESTMENT FUND, LLC
		
	By:		  

	Name:		
	Title:		Manager

 
			
	INVESTORS:
	
	SOFINNOVA VENTURE PARTNERS IX, L.P.
		
	By:		 Sofinnova Management IX, L.L.C.
 its General
Partner

		
	By:		  

	Name:		Srinivas Akkaraju
	Title:		Managing Member

 
			
	INVESTORS:
	
	T. Rowe Price Health Sciences Fund, Inc.
	TD Mutual Funds – TD Health Sciences Fund
	Valic Company I – Health Sciences Fund
	T. Rowe Price Health Sciences Portfolio
	John Hancock Variable Insurance Trust – Health Sciences Trust
	John Hancock Funds II – Health Sciences Fund,
	 Each fund, severally and not jointly

		
	By:		T. ROWE PRICE ASSOCIATES, INC.,
			Investment Adviser or Subadviser
		
	By:		  

	Name:		
	Title:		

 
			
	INVESTORS:
	
	RA CAPITAL HEALTHCARE FUND, LP
		
	 By:
 Name:

Title:
		  

		Peter Kolchinsky
		Manager

 
			
	INVESTORS:
	
	ORBIMED PRIVATE INVESTMENTS V, LP
	
	By: OrbiMed Capital GP V LLC, its General Partner
	By: OrbiMed Advisors LLC, is Managing Member
		
	By:		  

	Name:		
	Title:		

 
					
	INVESTORS:
	
	FLAGSHIP VENTURES FUND IV, L.P.
	
	By its General Partner
	Flagship Ventures Fund IV General Partner LLC
			
			By:		  

					Manager

  

					
	FLAGSHIP VENTURES FUND IV-Rx, L.P.
	
	By its General Partner
	Flagship Ventures Fund IV General Partner LLC
			
			By:		  

					Manager

  

					
	FLAGSHIP VENTURES FUND 2007, L.P.
	
	By its General Partner
	Flagship Ventures Fund 2007 General Partner LLC
			
			By:		  

					Manager

 
	
	INVESTORS:
	
	 ENSO VENTURES 2 LIMITED

BY INTERLOCK DIRECTOR LTD., DIRECTOR

	
	  

	AUTHORIZED SIGNATORY
	
	  

	AUTHORIZED SIGNATORY

 
			
	INVESTORS:
	
	MAYO CLINIC
		
	By:		  

			Name:
			Title:

 
			
	INVESTORS:
	
	 ALEXANDRIA EQUITIES, LLC,
 a
Delaware limited liability company

	
	By: ALEXANDRIA REAL ESTATE EQUITIES, INC., a Maryland corporation, managing member
		
	By:		  

			Name:
			Title:

 
	
	INVESTORS:
	
	  

	Roger J. Pomerantz, M.D.

 
					
	INVESTORS:
	
	FAVREAU 2008 TRUST, DTD 4-10-2008
		
	By:		  

			Name:		Jon Favreau
			Title:		Trustee
		
	By:		  

			Name:		Joya Favreau
			Title:		Trustee

 
	
	INVESTORS:
	
	  

	John Aunins

 
	
	INVESTORS:
	
	  

	David Cook

 
	
	INVESTORS:
	
	  

	Matthew Henn

 
			
	KEY HOLDERS:
	
	FLAGSHIP VENTURELABS IV LLC
		
	By:		FLAGSHIP VENTURES FUND IV, L.P.
			its Authorized Member
		
	By:		FLAGSHIP VENTURES FUND IV
			GENERAL PARTNER LLC
			its General Partner
		
	By:		  

			Name:
			Title:

 
	
	KEY HOLDERS:
	
	  

	John Aunins
	
	  

	Alexander Belanger
	
	  

	David Berry
	
	  

	Frank Bobe
	
	  

	Michael Briskin
	
	  

	George Church
	
	  

	James Collins
	
	  

	Allison DiGaetano
	
	  

	Anthony D’Onofrio
	
	  

	Andrew Goodman
	
	  

	Matthew Henn
	
	  

	Peter Barton Hutt
	
	  

	Avak Kahvejian
	
	  

	Kim Lewis

 
	
	  

	Tohiro Ohsumi
	
	  

	David Relman
	
	  

	Geoffrey von Maltzahn
	
	  

	Han Zhang

 SCHEDULE A 

INVESTORS 
  

			
	Name and Address
		
	 Fidelity Select Portfolios: Biotechnology Portfolio

Brown Brothers Harriman & Co.
 525 Washington Blvd

Jersey City NJ 07310
 Attn: Michael Lerman 15th Floor

Corporate Actions
 Email: michael.lerman@bbh.com

F: (617) 772-2418
		 Nestlé Health Science US Holdings, Inc.

900 Long Ridge Road, Building 2
 Stamford, CT 06902

Attention: Andrew Glass, Esq.
 Email:
andrew.glass@us.nestle.com
 F: (480) 379-5510
  

With a copy (which shall not constitute notice) to:
  

Nestlé Health Science S.A.
 Avenue Nestlé, 55

1800 Vevey
 Switzerland

Attention: Claudio Kuoni, Esq.
 Email:
Claudio.Kuoni@nestle.com
 F: 41.21.924.2875

		
	 Fidelity Advisor Series VII: Fidelity Advisor Biotechnology Fund

State Street Bank & Trust
 PO Box 5756

Boston, Massachusetts 02206
 Attn: Bangle & Co fbo
Fidelity Advisor Series VII: Fidelity Advisor Biotechnology Fund
 Email: SSBCORPACTIONS@StateStreet.com

F: (617) 988-9110
		 Leerink Swann Co-Investment Fund, LLC
 1 Federal
Street
 Boston, MA 02110
 Attention: General Counsel

F: (646) 499-7130

		
	 Fidelity Growth Company Commingled Pool
 Brown
Brothers Harriman & Co.
 525 Washington Blvd
 Jersey
City NJ 07310
 Attn: Michael Lerman 15th Floor
 Corporate
Actions
 Email: michael.lerman@bbh.com
 F:
(617) 772-2418
		 Leerink Holdings LLC
 1 Federal Street

Boston, MA 02110
 Attention: General Counsel

F: (646) 499-7130

		
	 Fidelity Mt. Vernon Street Trust: Fidelity Series Growth Company Fund

State Street Bank & Trust
 PO Box 5756
		 T. Rowe Price Health Sciences Fund, Inc.
 T.
Rowe Price Associates, Inc.
 100 East Pratt Street
 Baltimore,
MD 21202

			
	 Boston, Massachusetts 02206
 Attn: WAVELENGTH +
CO Fidelity Mt. Vernon Street Trust: Fidelity Series Growth Company Fund
 Email: SSBCORPACTIONS@StateStreet.com

F: (617) 988-9110
		 Attn: Andrew Baek, Vice President and Senior Legal Counsel

Phone: 410-345-2090
 E-mail:
andrew_baek@troweprice.com

		
	 Fidelity Mt. Vernon Street Trust: Fidelity Growth Company Fund

Ball & Co
 C/o Citibank N.A/Custody

IC&D Lock Box
 P.O Box 7247-7057

Philadelphia, P.A 19170-7057
 Account #: 206681

Email: fidelity.tpacd@citi.com
 F: 813-604-1415
		 VALIC Company I - Health Sciences Fund
 T. Rowe
Price Associates, Inc.
 100 East Pratt Street
 Baltimore, MD
21202
 Attn: Andrew Baek, Vice President and Senior Legal Counsel

Phone: 410-345-2090
 E-mail:
andrew_baek@troweprice.com

		
	 BlackRock Health Sciences Master Unit Trust
 c/o
BlackRock Advisors, LLC
 Fundamental Equity – Global Opportunities Health & Sciences Team

60 State Street, 19th/20th Floors
 Boston, MA 02109

Attn: Erin Xie, Chian Jiang
 Email: erin.xie@blackrock.com,
chian.jiang@blackrock.com
  
 With a copy (which shall not constitute notice) to:

 
 c/o BlackRock, Inc.

Office of the General Counsel
 40 East 52nd Street

New York, NY 10022
 Attn: David Maryles and Vincent Taurassi

Email: legaltransactions@blackrock.com
		 VALIC Company I - Health Sciences Fund
 T. Rowe
Price Associates, Inc.
 100 East Pratt Street
 Baltimore, MD
21202
 Attn: Andrew Baek, Vice President and Senior Legal Counsel

Phone: 410-345-2090
 E-mail:
andrew_baek@troweprice.com

		
	 BlackRock Health Sciences Trust
 c/o BlackRock
Advisors, LLC
 Fundamental Equity – Global Opportunities Health & Sciences Team

60 State Street, 19th/20th Floors
 Boston, MA 02109

Attn: Erin Xie, Chian Jiang
 Email: erin.xie@blackrock.com,
chian.jiang@blackrock.com
		 T. Rowe Price Health Sciences Portfolio
 T. Rowe
Price Associates, Inc.
 100 East Pratt Street
 Baltimore, MD
21202
 Attn: Andrew Baek, Vice President and Senior Legal Counsel

Phone: 410-345-2090
 E-mail:
andrew_baek@troweprice.com

			
		
	 With a copy (which shall not constitute notice) to:
  

c/o BlackRock, Inc.
 Office of the General Counsel

40 East 52nd Street
 New York, NY 10022

Attn: David Maryles and Vincent Taurassi
 Email:
legaltransactions@blackrock.com
		
		
	 BlackRock Health Sciences Master Unit Trust
 c/o
BlackRock Advisors, LLC
 Fundamental Equity – Global Opportunities Health & Sciences Team

60 State Street, 19th/20th Floors
 Boston, MA 02109

Attn: Erin Xie, Chian Jiang
 Email: erin.xie@blackrock.com,
chian.jiang@blackrock.com
  
 With a copy (which shall not constitute notice) to:

 
 c/o BlackRock, Inc.

Office of the General Counsel
 40 East 52nd Street

New York, NY 10022
 Attn: David Maryles and Vincent Taurassi

Email: legaltransactions@blackrock.com
		 John Hancock Variable Insurance Trust - Health Sciences Trust

T. Rowe Price Associates, Inc.
 100 East Pratt Street

Baltimore, MD 21202
 Attn: Andrew Baek, Vice President and Senior
Legal Counsel
 Phone: 410-345-2090
 E-mail:
andrew_baek@troweprice.com

		
	 Sofinnova Venture Partners IX, L.P.
 c/o
Sofinnova Ventures, Inc.
 Attention: Hooman Shahlavi
 3000 Sand
Hill Road, Bldg 4, Suite 250
 Menlo Park, CA 94025
		 John Hancock Funds II - Health Sciences Fund
 T.
Rowe Price Associates, Inc.
 100 East Pratt Street
 Baltimore,
MD 21202
 Attn: Andrew Baek, Vice President and Senior Legal Counsel

Phone: 410-345-2090
 E-mail:
andrew_baek@troweprice.com

		
	 OrbiMed Private Investments V, LP
 c/o OrbiMed
Advisors LLC
 Attention: Evan Sotiriou
 601 Lexington Ave.

54th Floor
 New York, NY 10022
		 RA Capital Healthcare Fund, LP
 c/o RA Capital
Management, LLC,
 Attention: Amanda Daniels
 20 Park Plaza,
Suite 1200
 Boston, MA 02116
 F: (617)
778-2510

			
	 Flagship Ventures Fund IV, L.P.
 c/o Flagship
Ventures
 One Memorial Drive
 Cambridge, MA 02142

F: (617) 868 -1115
		 Rock Springs Capital Master Fund LP
 Attention:
Evans Apeadu
 650 South Exeter Street, Suite 1070
 Baltimore,
MD 21202
 Email: evans@rockspringscapital.com

		
	 Flagship Ventures Fund IV-Rx, L.P.
 c/o Flagship
Ventures
 One Memorial Drive
 Cambridge, MA 02142

F: (617) 868 -1115
		 Roger J. Pomerantz, M.D.
 XXXXXXXXXXX

XXXXXXXXXXX

		
	 Flagship Ventures Fund 2007, L.P.
 c/o Flagship
Ventures
 One Memorial Drive
 Cambridge, MA 02142

F: (617) 868 -1115
		 Favreau 2008 Trust, dtd 4-10-2008

XXXXXXXXXXX
 XXXXXXXXXXX

F: (310) 858-3947

		
	 Enso Ventures 2 Limited
 Suite C1

Hirzel Court
 Hirzel Street

St Peter Port
 Guernsey

Channel Islands
 GY1 2NH

F: +44 (0) 1481 755859
		 John Aunins
 XXXXXXXXXXX

XXXXXXXXXXX
 F: (617) 945-0268

		
	 Mayo Clinic
 200 First Street SW

Rochester, MN 55905
 F: (507) 538-7802
		 David Cook
 XXXXXXXXXXX

XXXXXXXXXXX
 F: (617) 945-0268

		
	 Alexandria Equities, LLC
 385 E. Colorado Blvd.
Suite 299
 Pasadena, CA 91101
 F: (626) 578-0770
		 Matthew Henn
 XXXXXXXXXXX

XXXXXXXXXXX
 F: (617) 945-0268

 SCHEDULE B 

KEY HOLDERS 
  

			
	 Name and Address

	 Flagship VentureLabs IV LLC
 One Memorial
Drive
 Cambridge, MA 02142
		 Peter Barton Hutt
 c/o Covington &
Burling
 1201 Pennsylvania Avenue NW
 Washington, DC
20004

		
	 David Berry
 XXXXXXXXXXX

XXXXXXXXXXX
		 Andrew Goodman
 XXXXXXXXXXX

XXXXXXXXXXX

		
	Alexander Belanger		 Avak Kahvejian
 XXXXXXXXXXX

XXXXXXXXXXX

		
	 Frank Bobe
 XXXXXXXXXXX

XXXXXXXXXXX
		 Kim Lewis
 XXXXXXXXXXX

XXXXXXXXXXX

		
	 Michael Briskin
 XXXXXXXXXXX

XXXXXXXXXXX
		 John Aunins
 XXXXXXXXXXX

XXXXXXXXXXX

		
	 George Church
 XXXXXXXXXXX

XXXXXXXXXXX
		 Toshiro K. Ohsumi
 XXXXXXXXXXX

XXXXXXXXXXX

		
	 James Collins
 XXXXXXXXXXX

XXXXXXXXXXX
		 David Relman
 XXXXXXXXXXX

XXXXXXXXXXX

		
	 Allison DiGaetano
 XXXXXXXXXXX

XXXXXXXXXXX
		 Geoffrey von Maltzahn
 XXXXXXXXXXX

XXXXXXXXXXX

		
	 Anthony D’Onofrio
 XXXXXXXXXXX

XXXXXXXXXXX
		 Han Zhang
 XXXXXXXXXXX

XXXXXXXXXXX

		
	 Matthew Henn
 XXXXXXXXXXX

XXXXXXXXXXX
		

 EXHIBIT A 

ADOPTION AGREEMENT 
 This
Adoption Agreement (“Adoption Agreement”) is executed on                     , 20    , by the undersigned (the
“Holder”) pursuant to the terms of that certain Amended and Restated Voting Agreement dated as of December 19, 2014 (the “Agreement”), by and among the Company and certain of its Stockholders, as such Agreement
may be amended or amended and restated hereafter. Capitalized terms used but not defined in this Adoption Agreement shall have the respective meanings ascribed to such terms in the Agreement. By the execution of this Adoption Agreement, the Holder
agrees as follows. 
 1.1 Acknowledgement. Holder acknowledges that Holder is acquiring certain shares of the capital stock of the
Company (the “Stock”) or options, warrants or other rights to purchase such Stock (the “Options”), for one of the following reasons (Check the correct box): 

 

	 	 ̈	as a transferee of Shares from a party in such party’s capacity as an “Investor” bound by the Agreement, and after such transfer, Holder shall be considered an “Investor” and a
“Stockholder” for all purposes of the Agreement. 

  

	 	 ̈	as a transferee of Shares from a party in such party’s capacity as a “Key Holder” bound by the Agreement, and after such transfer, Holder shall be considered a “Key Holder” and a
“Stockholder” for all purposes of the Agreement. 

  

	 	 ̈	as a new Investor in accordance with Subsection 7.1(a) of the Agreement, in which case Holder will be an “Investor” and a “Stockholder” for all purposes of the Agreement. 

 

	 	 ̈	in accordance with Subsection 7.1(b) of the Agreement, as a new party who is not a new Investor, in which case Holder will be a “Key Holder” and a “Stockholder” for all purposes of the
Agreement. 

 1.2 Agreement. Holder hereby (a) agrees that the Stock, Options and any other shares of capital
stock or securities required by the Agreement to be bound thereby, shall be bound by and subject to the terms of the Agreement and (b) adopts the Agreement with the same force and effect as if Holder were originally a party thereto. 

1.3 Notice. Any notice required or permitted by the Agreement shall be given to Holder at the address or facsimile number listed below
Holder’s signature hereto. 
  

									
	HOLDER:		  
				ACCEPTED AND AGREED:
				
	By:		  
				SERES HEALTH, INC.
			Name and Title of Signatory						
					
	Address:		  
				By:		  

				
	  
				Title:		  

 

							
	Facsimile Number:		  
				

 EXHIBIT B 

CONSENT OF SPOUSE 
 I,
[                    ], spouse of
[                    ], acknowledge that I have read the Amended and Restated Voting Agreement, dated as of December 19, 2014, to which this
Consent is attached as Exhibit B (the “Agreement”), and that I know the contents of the Agreement. I am aware that the Agreement contains provisions regarding the voting and transfer of shares of capital stock of the Company that my
spouse may own, including any interest I might have therein. 
 I hereby agree that my interest, if any, in any shares of capital stock of
the Company subject to the Agreement shall be irrevocably bound by the Agreement and further understand and agree that any community property interest I may have in such shares of capital stock of the Company shall be similarly bound by the
Agreement. 
 I am aware that the legal, financial and related matters contained in the Agreement are complex and that I am free to seek
independent professional guidance or counsel with respect to this Consent. I have either sought such guidance or counsel or determined after reviewing the Agreement carefully that I will waive such right. 

 

							
	Dated:		  
				  

							[Name of Key Holder’s Spouse]

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