Document:

Amendment, dated January 9, 2004, to Executive Employment Agreement

 Exhibit 10.49 
 AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT 
 THIS AMENDMENT (this
“Amendment”) dated as of January 9, 2004 by and between QUINTILES TRANSNATIONAL CORP., a North Carolina corporation (the “Company”) and Michael Mortimer (“Executive”). 

WHEREAS, the Company and Executive have entered into that certain Executive Employment Agreement, dated as of June 1, 2003 (the
“Agreement”); and 
 WHEREAS, the Company and Executive desire to amend the Agreement to reflect the acquisition of
the Company on September 25, 2003 by Pharma Services Holding, Inc., a Delaware Corporation (“Pharma”) pursuant to that certain Agreement and Plan of Merger, dated as of April 10, 2003 by and among the Company, Pharma and Pharma
Services Acquisition Corp., a North Carolina corporation and wholly-owned subsidiary of Pharma. 
 NOW, THEREFORE, in
consideration of the mutual covenants and agreements and the representations and warranties herein contained, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereto hereby
agree that the Agreement shall be amended as follows, effective as of September 25, 2003: 
 1.     Section 2 of
the Agreement shall be amended by deleting the phrase “reporting directly to the Chairman,” in the first sentence thereof and by adding the following sentence to the end of the first paragraph thereof: 

Executive shall also serve, without additional compensation, in such other officer and director positions of Affiliates to which he may
be appointed. 
 2.     Section 3.1 of the Agreement shall be amended to replace “$350,000” with
“$400,000”. 
 3.     Section 3.2 of the Agreement shall be amended to read as follows: 

3.2 ANNUAL CASH BONUS PLAN. Executive may participate on a basis commensurate with his position as a senior executive
officer, as determined by the Company, in the Company’s annual cash bonus plan which may be made available from time to time to Company executives; provided, however, that Executive’s participation is subject to the applicable terms,
conditions and eligibility requirements of the plan documents, some of which are within the plan administrator’s discretion, as they may exist from time to time. 
 4.     Section 5.2 shall be amended to read as follows: 

5.2 If the Company terminates Executive’s employment pursuant to Section 4.1 (notice of non-renewal) or 4.2 (without cause), or
if Executive terminates 

 
Executive’s employment pursuant to Section 4.4 (breach of Agreement), then the Company’s sole obligation to Executive, in lieu of any other damages or other relief to which he
otherwise may be entitled, shall be to pay: (i) amounts due on the effective date of the termination; (ii) any amounts subsequently due pursuant to the plan described in Section 3.2; and (iii) subject to Executive’s
compliance with Sections 6, 7, 8 and 9 and subject to Sections 3.7 and 5.6 (release), 24 monthly payments, where each payment equals Executive’s monthly rate of base salary in effect at the time of such termination multiplied by 1.55.

 5.     The first sentence of Section 5.3 of the Agreement shall be amended by adding “(but in no event after
the date the Executive becomes eligible for comparable coverage)” immediately after the reference to Section 5.2. 
 6.
    Section 5.5 of the Agreement shall be deleted in its entirety and labeled “[Reserved]”. 
 12.
    Section 14 of the Agreement shall be amended to read as follows: 
 14.
    ENTIRE AGREEMENT. This Agreement, along with two letters from Pharma to Executive, each dated January 9, 2003 relating to the acquisition of stock under the Pharma Stock Incentive Plan (collectively, the “Pharma
letters”), (i) supersede all other understandings, offers and agreements, oral or written, between or among Executive, Pharma, the Company or any of their affiliates; and (ii) constitute the sole agreement between or among Executive,
Pharma and the Company with respect to employment, compensation (including equity compensation) and benefits. Executive acknowledges that: (i) no representations, inducements, promises or agreements, oral or written, have been made by any party
or by anyone acting on behalf of any party, which are not embodied in this Agreement or the Pharma letters; and (ii) no agreement, statement or promise not contained in this Agreement or the Pharma letters shall be valid. No change or
modification of this Agreement shall be valid or binding upon the parties unless such change or modification is in writing and is signed by the parties. 
 13.     A new Section 19 shall be added to the Agreement to read as follows: 
 18.     TAX WITHHOLDING. The Company shall have the right to deduct and withhold such amounts from any payment made hereunder as may be necessary to enable the Company to satisfy any
applicable withholding obligation imposed by law. 

  
 2 

 IN WITNESS WHEREOF, this Amendment has been duly executed and delivered by Executive and by
a duly authorized officer of the Company as of the date and year first above written. 
  

			
	QUINTILES TRANSNATIONAL CORP.
		
	By:	 	 /s/ KELLEY MOYE

	Name:	 	VP + Assoc. Gen. Counsel
	Title:	 	QTRN
	
	 /s/ Michael Mortimer

	Michael Mortimer

  
 3Second Amendment, dated December 30, 2008, to Executive Employment Agreement

 Exhibit 10.50 
 SECOND AMENDMENT TO 
 EXECUTIVE EMPLOYMENT AGREEMENT 

This SECOND AMENDMENT TO EXECUTIVE EMPLOYMENT AGREEMENT (“Second Amendment”) is made and entered into as of the 30 day
of December, 2008 by and between QUINTILES TRANSNATIONAL CORP., a North Carolina corporation (the “Company”), and MICHAEL MORTIMER (“Executive”). 

WHEREAS, Executive is currently employed under an Executive Employment Agreement with the Company, dated June 1, 2003 (the
“Employment Agreement”), and currently serves as Executive Vice President and Chief Administration Officer, directly reporting to the Chairman and Chief Executive Officer of the Company; 

WHEREAS, the Company and Executive amended the Employment Agreement by an Amendment to Executive Employment Agreement dated
January 9, 2004 (the “First Amendment”); 
 WHEREAS, the Company and Executive desire to amend further the
Employment Agreement to memorialize new compensation arrangements approved by the Company’s Board of Directors in November 2006 and December 2007, and to evidence compliance with Section 409A of the Internal Revenue Code of 1986, as
amended (the “Code”), and the regulations thereunder (collectively, “Section 409A”); and 
 NOW,
THEREFORE, in consideration of the mutual covenants and agreements set forth below and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the Company and Executive agree that the Employment
Agreement, as amended by the First Amendment (the “Amended Employment Agreement”), shall be further amended as follows: 
 1. COMPENSATION. Section 3, COMPENSATION, of the Amended Employment Agreement is deleted in its entirety and the following Section is inserted in lieu thereof: 

“3. COMPENSATION. 

3.1 Base Salary. Executive’s annual salary for all services rendered shall be Four Hundred Fifty
Thousand and No/100 Dollars ($450,000.00) (less any applicable taxes and withholdings), payable in accordance with the Company’s policies, procedures, and practices as they may exist from time to time. Executive’s salary may be reviewed
and is subject to adjustment in accordance with the Company’s policies, procedures, and practices as they may exist from time to time. 

 3.2 Performance Incentive Plan. Executive may participate on
a basis commensurate with his position as a senior executive officer, as determined by the Company, in the Quintiles Performance Incentive Plan. For the year 2008, Executive is eligible to participate at a target level of eighty-five percent
(85%) of his annual base salary. This target level may be increased or decreased in subsequent years at the discretion of the Company. Beginning with the year 2008, the Performance Incentive Plan cap shall increase to two hundred percent
(200%) of target, based on Company and personal performance. Any Bonus paid to Executive shall be less applicable withholdings and shall be distributed pursuant to policies as determined by the Company, but in no event later than March 15
of the calendar year following the calendar year in which such Bonus was earned, 
 3.3 Annual Executive
Allowance. Each year during the term of this Amended Employment Agreement, Executive shall be entitled to receive payment of Thirty Thousand and No/100 Dollars ($30,000.00), less any applicable taxes and withholdings, as an Executive
Allowance. The Executive Allowance shall be paid in substantially equal installment payments in accordance with the Company’s normal payroll practices. This Executive Allowance is intended to be used for miscellaneous expenses and allowances
previously provided by the Company such as car allowance, tax return preparation fees, financial planning fees, legal fees, and the micropurchase plan. 
 3.4 Other Benefits. Executive may participate in all medical, dental and disability insurance, 401(k), pension, personal leave, and other benefit plans and programs provided by the Company
to other employees at Executive’s level except that Executive may not receive severance payments other than as specified in this Amended Employment Agreement; provided, however, that Executive’s participation in such benefit plans and
programs is subject to the applicable terms, conditions and eligibility requirements of these plans and programs, some of which are in the plan administrator’s discretion, as they may exist from time to time. 

3.5 Business Expenses. Executive shall be reimbursed for reasonable and necessary expenses actually
incurred by him in performing services under this Amended Employment Agreement in accordance with and subject to the terms and conditions of the applicable Company reimbursement policies, procedures, and practices as they may exist from time to
time. Expenses covered by this provision include, but are not limited to, travel, entertainment, professional dues and subscriptions, and dues, fees, and expenses associated with membership in various professional and business and civic associations
in which Executive’s participation is in the Company’s best interest. All such 

  
 2 

 
reimbursements shall be made no later than March 15 of the calendar year following the calendar year in which the expenses were incurred. 

3.6 Modifications or Revisions of Benefit Plans and Programs. Nothing in this Amended Employment
Agreement shall require the Company to create, continue, or refrain from amending, modifying, revising, or revoking any of the plans, programs, or benefits set forth in Sections 3.2 through 3.5. Any amendments, modifications, revisions, and
revocations of these plans, programs, and benefits shall apply to Executive. 
 3.7 Offset for Disability
Payments. If, at any time, during which Executive is receiving salary or post-termination payments from the Company, he receives payments on account of mental or physical disability from any Company-provided plan, then the Company, at its
discretion, may reduce his salary or post-termination payments by the amount of such disability payments.” 
 2. TERM OF
EMPLOYMENT. Section 4, TERM OF EMPLOYMENT, of the Amended Employment Agreement shall be amended as follows: 

Executive’s Right to Terminate for a Breach by the Company. Section 4.4 of the Amended Employment Agreement is
deleted in its entirety and the following Section is inserted in lieu thereof: 
 “4.4 Executive may terminate
employment in the event the Company materially breaches this Agreement if: (i) Executive provides the Company with written notice of the material breach of this Agreement within ninety (90) days of the initial actions or inactions of the
Company giving rise to such breach; (ii) the Company has not cured such breach within ninety (90) days of such notice (“Cure Period”); and (iii) if the Company fails to cure such breach, Executive terminates employment under
this Agreement within ninety (90) days of the expiration of the Cure Period.” 

  
 3 

 3. COMPENSATION AND BENEFITS UPON TERMINATION. Section 5, COMPENSATION
AND BENEFITS UPON TERMINATION, of the Amended Employment Agreement shall be amended as follows: 
  

	 	(a)	Termination by the Company Without Cause or for Non-Renewal or by the Executive for a Material Breach. Section 5.2 of the Amended Employment
Agreement is deleted in its entirety and the following Section is inserted in lieu thereof: 

“If the Company terminates Executive’s employment pursuant to Section 4.1 (notice of non-renewal) or 4.2
(without cause), or if Executive terminates Executive’s employment pursuant to Section 4.4 (material breach of Agreement), then the Company’s sole obligation to Executive, in lieu of any other damages or other relieve to which he
otherwise may be entitled, shall be to pay: (i) amounts due on the effective date of the termination of employment; (ii) any amounts subsequently due pursuant to the plan described in Section 3.2, and (iii) subject to
Executive’s compliance with Sections 6, 7, 8 and 9, and subject to Sections 3.7 and 5.6, an amount equal to the sum of 1.55 times his then current monthly base salary (less applicable withholdings) multiplied by thirty-six (36), plus an amount
equal to three (3) times his Annual Executive Allowance under Section 3.3, such sum to be payable in lump sum (less applicable withholdings) within ten (10) calendar days following the effective date of the general release required by
Section 5.6, but not later than ninety (90) days following termination.” 
  

	 	(b)	Benefit Continuation. Section 5.3 of the Amended Employment Agreement is deleted in its entirety and the following Section is inserted in lieu
thereof: 

 “5.3 In the event Executive is receiving payments under Section 5.2 of the
Amended Employment Agreement, and subject to Executive’s compliance with Sections 6,7, 8 and 9, and subject to Sections 3.7 and 5.6, Executive shall be entitled to a lump sum payment equal to thirty six (36) multiplied by the
Company’s monthly cost for providing the type of medical, dental, vision, long term disability and term life insurance coverage, as applicable, in effect for Executive (e.g., family coverage vs. employee-only coverage) at the time of his
termination, payable in a one-time lump sum payment, less any applicable tax withholdings, within ten (10) calendar days following the effective date of the general release required by Section 5.6, but not later than ninety (90) days
following termination from employment. Any payment under this section that is includible in Executive’s gross income shall be increased by an additional amount equal to the Federal income tax applicable to such payment determined by applying
the highest marginal Federal tax rate in effect at the payment date. Executive shall bear full responsibility for applying for COBRA continuation coverage and for obtaining coverage under any other insurance policy following termination of
employment, and nothing herein shall constitute a guarantee of 

  
 4 

 
COBRA continuation coverage or benefits or a guarantee of eligibility for health, dental, long term disability or term life insurance coverage.” 

 

	 	(c)	Release of Claims as a Condition of Payment from the Company. Section 5.6 of the Amended Employment Agreement is deleted in its entirety and the
following Section is inserted in lieu thereof: 

 “5.6 Notwithstanding any provision
of this Amended Employment Agreement to the contrary, the Company’s obligation to provide the payments and benefits under Sections 5.2 and 5.3 of this Amended Employment Agreement is conditioned upon Executive’s execution of an enforceable
release of claims and his compliance with Sections 6, 7, 8 and 9 of this Amended Employment Agreement. If Executive chooses not to execute such a release or fails to comply with these sections, then the Company’s obligation to compensate him
ceases on the effective termination date except as to amounts due at the time and any amount subsequently due pursuant to the plan described in Section 3.2. The release of claims shall be provided to Executive within thirty (30) days of
his separation from service and Executive must execute it within the time period specified in the release (which shall not be longer than forty five (45) days from the date of receipt). Such release shall not be effective until any applicable
revocation period has expired.” 
 4. SECTION 409A OF THE INTERNAL REVENUE CODE. The following provisions shall be
added to the end of the Amended Employment Agreement as Section 19: 
 “19 Section 409A of
the Internal Revenue Code 
 19.1 Parties’ Intent. The parties intend that the provisions of
this Amended Employment Agreement comply with the Internal Revenue Code of 1986, as amended (the “Code”), and the regulations thereunder (collectively, “Section 409A”) and all provisions of this Amended Employment Agreement shall
be construed in a manner consistent with the requirements for avoiding taxes or penalties under Section 409A. If any provision of this Amended Employment Agreement (or of any award of compensation, including equity compensation or benefits)
would cause Executive to incur any additional tax or interest under Section 409A, the Company shall, upon the specific request of Executive, use its reasonable business efforts to in good faith reform such provision to comply with Code
Section 409A; provided, that to the maximum extent practicable, the original intent and economic benefit to Executive and the Company of the applicable provision shall be maintained, and the Company shall have no obligation to make any
changes that could create any additional economic cost or loss of benefit to the Company. The Company shall timely use its reasonable business efforts to amend any plan or program in which Executive participates to bring it in compliance with
Section 409A. Notwithstanding the foregoing, the 

  
 5 

 
Company shall have no liability with regard to any failure to comply with Section 409A so long as it has acted in good faith with regard to compliance therewith. 

19.2 Separation from Service. A termination of employment shall not be deemed to have occurred for purposes of any provision
of this Amended Employment Agreement providing for the payment of any amounts or benefits upon or following a termination of employment unless such termination also constitutes a “Separation from Service” within the meaning of
Section 409A and, for purposes of any such provision of this Amended Employment Agreement, references to a “termination,” “termination of employment,” “separation from service” or like terms shall mean Separation
from Service. 
 19.3 Separate Payments. Each installment payment required under this Amended Employment Agreement
shall be considered a separate payment for purposes of Section 409A. 
 19.4 Delayed Distribution to Key
Employees. If the Company determines in accordance with Sections 409A and 416(i) of the Code and the regulations promulgated thereunder, in the Company’s sole discretion, that Executive is a Key Employee of the Company on the date
his/her employment with the Company terminates and that a delay in benefits provided under this Amended Employment Agreement is necessary to comply with Code Section 409A(A)(2)(B)(i), then any severance payments and any continuation of benefits
or reimbursement of benefit costs provided by this Amended Employment Agreement, and not otherwise exempt from Section 409A, shall be delayed for a period of six (6) months following the date of termination of Executive’s employment
(the “409A Delay Period”). In such event, any severance payments and the cost of any continuation of benefits provided under this Amended Employment Agreement that would otherwise be due and payable to Executive during the 409A Delay
Period shall be paid to Executive in a lump sum cash amount in the month following the end of the 409A Delay Period. For purposes of this Amended Employment Agreement, “Key Employee” shall mean an employee who, on an Identification Date
(“Identification Date” shall mean each December 31) is a key employee as defined in Section 416(i) of the Code without regard to paragraph (5) thereof. If Executive is identified as a Key Employee on an Identification Date,
then Executive shall be considered a Key Employee for purposes of this Amended Employment Agreement during the period beginning on the first April 1 following the Identification Date and ending on the following March 31.” 

5. COUNTERPARTS. This Second Amendment may be executed in counterparts, each of which shall be an original, with the same effect
as if the signatures affixed thereto were upon the same instrument. 

  
 6 

 6. DEFINITIONS. All terms used in this Second Amendment shall have the same
definitions as used in the Amended Employment Agreement, unless otherwise provided herein. All references to “Amended Employment Agreement” shall include all modifications made by this Second Amendment, unless provided otherwise.

 7. EFFECT OF AMENDMENT. Except as amended hereby, the Amended Employment Agreement shall remain in full force and
effect and is hereby ratified and confirmed by the Company and Executive in all respects. 
 [Remainder of page intentionally
left blank] 

  
 7 

 IN WITNESS WHEREOF, this Second Amendment has been duly executed as of the day and
year set forth above. 
  

					
	QUINTILES TRANSNATIONAL CORP.
		
	By:	 	 /s/ Betsy B. Walker

		 	Name:	 	Betsy B. Walker
		 	Title:	 	 Vice President, Human Resources,

Global Compensation & Benefits

	
	EXECUTIVE:
	
	 /s/ Michael Mortimer

	Michael Mortimer

  
 8

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00212-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00212-of-00352.parquet"}]]