Document:

AMENDMENT AGREEMENT

         This amendment agreement (the "Agreement") entered into this 15th day
of March, 2006 between Sat-Net Communications, L.L.C. ("Sat-Net"), a Texas
limited liability company having its principal place of business located at 5000
Legacy Drive, Suite 470, Plano, Texas, 75024 and SiriCOMM, Inc. ("SiriCOMM"), a
Delaware corporation having its principal place of business located at 2900
Davis Boulevard, Suite 130, Joplin, Missouri, 64804.

         WHEREAS, SiriCOMM is in the process of redeveloping a broadband
wireless network infrastructure (the "Network") for the commercial
transportation industry market that, when finished, will allow users to connect
to the SiriCOMM network through wireless transmission and receiving equipment
installed in strategic locations that will include, but not be limited to, truck
stops and weigh stations;

         WHEREAS, in connection with developing the Network, SiriCOMM entered
into a Network Installation Agreement with Sat-Net dated February 7, 2005 (the
"Original Agreement") which provided for among other things, that Sat-Net was to
provide and install its VSAT/802.11 terminals (the "Terminals") at SiriCOMM's
designated locations;

         WHEREAS, SiriCOMM has experienced technical difficulties (of which
Sat-Net does not admit or deny) with the Terminals which have caused SiriCOMM to
expend additional costs to have the Terminals meet their intended needs and
specifications:

         WHEREAS, SiriCOMM and Sat-Net wish to amend the Original Agreement as a
result of the foregoing.

         NOW, THEREFORE, for and in consideration of the premises, and other
good and valuable consideration, the receipt and sufficiency of which is hereby
acknowledged, the parties agree as follows:

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         1.   Sat-Net Provision of Servers. Sat-Net will cause to be delivered
              Ninety (90) Remote servers to complete the original contract. Such
              Remote Servers shall meet or exceed the specifications of the
              servers previously delivered.

              Whereas SiriCOMM has previously received remote servers and access
              points which no longer function and are out of warranty, Sat-Net
              agrees to reimburse SiriCOMM, Inc. in the amount of $50,000.
              SiriCOMM agrees to forestall such reimbursement and will
              ultimately forgive such payment should Sat-Net cause Idling
              Solutions to purchase more than 20,000 Pulse Units within eighteen
              (18) months from the successful 900 mhz operation of the SiriCOMM
              Network.

              The original purchase order has been reduced by 140 access points
              and SiriCOMM is to be credited $92,000 of which is specified in
              the Agreement by and between SiriCOMM and DirecTruck dated on or
              about the same time as this agreement. (A copy of which is
              attached to this agreement.)

         2.   Sat-Net Provision of SiriCOMM Common Stock. As part of a master
              settlement, Sat-Net will assign 200,000 shares of SiriCOMM's
              Common Stock, which was issued to Sat-Net as part of the Original
              Agreement, to IRG for the benefit of SiriCOMM within three days of
              execution of this Agreement, assuming SiriCOMM is in compliance
              with all of its responsibilities as set forth in the Original
              Agreement.

         3.   Deliveries to Cadco. Sat-Net shall deliver to Cadco Systems or pay
              directly to Cadco the cost of the servers to ensure the delivery
              of the 90 Remote Servers to SiriCOMM and get a release from Cadco.

         4.   Effect of Original Agreement. Except as supplemented and amended
              by this Agreement and such conforming changes as necessary to
              reflect the modification herein, all of the provisions of the

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              Original Agreement shall remain in full force and effect from and
              after the effective date of this Agreement.

              All parties agree to commit to timely completion of account
              reconciliation among the parties (SiriCOMM, Cadco, Sat-Net, and
              ViaSat). Sat-Net will have new purchase order for balance of
              network equipment due to be executed between Cadco and SiriCOMM.

         5.   Mutual Release. Sat-Net and SiriCOMM herein releases the other
              party, and his successors and assigns, from all liability for
              claims and/or demands which may exist except to what is agreed to
              herein.

              This Agreement has been duly authorized and approved by both
              companies and does not violate the certificate of incorporation or
              bylaws of either company.

         IN WITNESS WHEREOF, the parties have executed this Agreement through
their duly authorized representatives as of the date first written above.

SAT-NET COMMUNICATIONS, L.L.C.                  SIRICOMM, INC.

/s/ John R. Bailey                              /s/ Henry P. Hoffman
------------------------------                  --------------------------------
By:    John R. Bailey                           By:
   ---------------------------                     -----------------------------
Its:    CEO                                     Its:
     -------------------------                      ----------------------------

                                       3AGREEMENT

         This agreement (the "Agreement") entered into this 15th day of March,
2006 between SiriCOMM, Inc. ("SiriCOMM"), a Delaware corporation having its
principal place of business located at 2900 Davis Boulevard, Suite 130, Joplin,
Missouri, 64804 and DirecTruck, L.L.C., a Texas limited liability company having
its principal place of business located at 5000 Legacy Drive, Suite 470, Plano,
Texas, 75024 ("DirecTruck").

         WHEREAS, DirecTruck has developed a 915 mhz broadband wireless network
infrastructure for the commercial transportation industry market that will allow
users to connect to the SiriCOMM network through wireless transmission and
receiving equipment installed in strategic locations that include truck stops
and weigh stations, and a wireless truck data gathering device:

         WHEREAS, SiriCOMM desires to purchase the rights to DirecTruck wireless
truck data gathering device;

         NOW, THEREFORE, for and in consideration of the premises, and other
good and valuable consideration, the receipt and sufficiency of which is hereby
acknowledged, the parties agree as follows:

         1.   DirecTruck will assign, convey, and transfer to SiriCOMM all
              proprietary rights and other rights, title, and interest
              associated with the development of a 915 mhz truck data system
              including but not limited to, all contracts, drawings,
              intellectual property, test results and research and such
              information and data to insure SiriCOMM obtains ownership of the
              technology related to the product known as the Pulse Box ("Pulse
              Box").

         2.   SiriCOMM will pay the sum of $XXX,XXX for the rights to the Pulse
              Box which will be paid $XXX,XXX upon signing of this Contract,
              $XXX,XXX three (3) months from the signing of this contract and as
              part of SiriCOMM's settlement with Sat-Net Communications, an
              affiliated company of DirecTruck, $XX,XXX will be credited to

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              SiriCOMM subject to delivery of a signed and executed agreement by
              and between SiriCOMM and Sat-Net Communications, L.L.C. dated the
              same time as this agreement. (A copy of which is attached.)

         3.   Idling Solutions shall deliver as Exhibit A of this contract its
              best estimate of Pulse Box usage and timing. Idling Solutions
              agrees to use SiriCOMM as its exclusive supplier of their
              monitoring network made capable by the Pulse Box.

         4.   DirecTruck will transfer all rights hereinafter referred to as
              Back-Up-Rights to produce and use the Pulse Box and its underlying
              technology to Idling Solutions. SiriCOMM will also allow Idling
              Solutions to purchase the Pulse Box directly from SiriCOMM's
              supplier (on the same terms and conditions as SiriCOMM) in the
              event SiriCOMM is unable to provide Pulse Boxes on a timely basis.

         5.   DirecTruck, Sat-Net Communications, Idling Solutions and all
              affiliated entities shall only produce the Pulse Box or utilize
              any of its network technology in the event that SiriCOMM becomes
              insolvent, files bankruptcy or does not deliver product to Idling
              Solutions within thirty days of receipt of a purchase order.

         This Agreement has been duly authorized and approved by all required
corporate action by each company and does not violate their respective
certificates of incorporation or bylaws.

         IN WITNESS WHEREOF, the parties have executed this Agreement through
their duly authorized representatives as of the date first written above.

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<PAGE>

SIRICOMM, INC.                                       DIRECTRUCK, L.L.C.

/s/ Henry P. Hoffman                                  /s/ David E. Webb
---------------------------------                    ---------------------------
By: _____________________________                    By:________________________
Its:_____________________________                    Its:_______________________

                                       3<Page>

                                                                     EXHIBIT 4.5

NEITHER THIS WARRANT NOR THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT
HAVE BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. NO SALE OR
DISPOSITION MAY BE EFFECTED EXCEPT IN COMPLIANCE WITH RULE 144 UNDER SAID ACT OR
WITHOUT AN EFFECTIVE REGISTRATION STATEMENT RELATED THERETO OR (IF REASONABLY
REQUIRED BY THE COMPANY) AN OPINION OF COUNSEL FOR THE HOLDER, SATISFACTORY TO
THE COMPANY, THAT SUCH REGISTRATION IS NOT REQUIRED UNDER THE ACT OR RECEIPT OF
A NO-ACTION LETTER FROM THE SECURITIES AND EXCHANGE COMMISSION.

                 WARRANT TO PURCHASE 471 SHARES OF COMMON STOCK

                                  June 28, 2005

THIS CERTIFIES THAT, for value received, GENERAL ELECTRIC CAPITAL CORPORATION
("HOLDER") is entitled to subscribe for and purchase FOUR HUNDRED SEVENTY
ONE(471) shares of the fully paid and nonassessable Common Stock (the "SHARES"
or the "STOCK") of COMBINATORX, INC., a Delaware corporation (the "COMPANY"), at
the Warrant Price (as hereinafter defined), subject to the provisions and upon
the terms and conditions hereinafter set forth.

1.  WARRANT PRICE. The Warrant Price shall initially be $6.75 per share, subject
to adjustment as provided in Section 7 below.

2.  CONDITIONS TO EXERCISE. The purchase right represented by this Warrant may
be exercised at any time, or from time to time, in whole or in part during the
term commencing on the date hereof and ending at 5:00 P.M. Eastern time on the
tenth anniversary of the date of this Warrant.

3.  METHOD OF EXERCISE; PAYMENT; ISSUANCE OF SHARES; ISSUANCE OF NEW WARRANT.

(a) CASH EXERCISE. Subject to Section 2 hereof, the purchase right represented
by this Warrant may be exercised by the Holder hereof, in whole or in part, by
the surrender of this Warrant (with a duly executed Notice of Exercise in the
form attached hereto) at the principal office of the Company (as set forth in
Section 18 below) and by payment to the Company, by check, of an amount equal to
the then applicable Warrant Price per share multiplied by the number of shares
then being purchased. In the event of any exercise of the rights represented by
this Warrant, certificates for the shares of stock so purchased shall be in the
name of, and delivered to, the Holder hereof, or as such Holder may direct
(subject to the terms of transfer contained herein and upon payment by such
Holder hereof of any applicable transfer taxes). Such delivery shall be made
within 30 days after exercise of the Warrant and at the Company's expense and,
unless this Warrant has been fully exercised or expired, a new Warrant having
terms and conditions substantially identical to this Warrant and representing
the portion of the Shares, if any, with respect to which this Warrant shall not
have been exercised, shall also be issued to the Holder hereof within 30 days
after exercise of the Warrant.

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(b) NET ISSUE EXERCISE. Holder may also elect to receive shares equal to the
value of this Warrant (or of any portion thereof remaining unexercised) by
surrender of this Warrant at the principal office of the Company together with
notice of such election, in which event the Company shall issue to Holder the
number of shares of the Company's Common Stock computed using the following
formula:

     X = Y (A-B)
         ------
            A
     Where X = the number of shares of Stock to be issued to Holder.
     Y = the number of shares of Stock purchasable under this Warrant (at the
            date of such calculation).
     A = the Fair Market Value of one share of the Company's Common Stock (at
            the date of such calculation).
     B = Warrant Price (as adjusted to the date of such calculation).

(c) FAIR MARKET VALUE. For purposes of this Section 3, Fair Market Value of one
share of the Company's Stock shall mean:

     (i)    In the event of an exercise in connection with an Initial Public
     Offering, the per share Fair Market Value for the Stock shall be the
     Offering Price at which the underwriters initially sell Common Stock to
     the; or
     (ii)   The average of the closing bid and asked prices of Common Stock
     quoted in the Over-The-Counter Market Summary or the last reported sale
     prices quoted on the Nasdaq National Market ("NNM") or on any exchange on
     which the Common Stock is listed, whichever is applicable, as published in
     the Western Edition of the WALL STREET JOURNAL for the 21 trading days
     prior to the date of determination of Fair Market Value; or
     (iii)  In the event of an exercise in connection with a merger, acquisition
     or other consolidation in which the Company is not the surviving entity,
     the per share Fair Market Value for the Stock shall be the value to be
     received per share of Common Stock by all holders of the Common Stock in
     such transaction as determined by the Board of Directors; or
     (iv)   In any other instance, the per share Fair Market Value for the Stock
     shall be as determined in good faith by the Company's Board of Directors.
     In the event of 3(c)(iii) or 3(c)(iv), above, the Company's Board of
     Directors shall prepare a certificate, to be signed by an authorized
     officer of the Company, setting forth in reasonable detail the basis for
     and method of determination of the per share Fair Market Value of the
     Stock. In the event of 3(c)(iii) above, the Board will also certify to the
     Holder that this per share Fair Market Value will be applicable to all
     holders of the Company's Common Stock. Such certification must be made to
     Holder at least ten business days prior to the proposed effective date of
     the merger, consolidation, sale, or other triggering event as defined in
     3(c)(iii).

(d) AUTOMATIC EXERCISE. To the extent this Warrant is not previously exercised,
it shall be automatically exercised in accordance with Sections 3(b) and 3(c)
hereof (even if not surrendered) immediately before its expiration, involuntary
termination or cancellation.

(e) MANDATORY REDEMPTION. At any time, prior to the exercise of this warrant,
the Holder may at its option require the Company to redeem this Warrant for a
price of $XX (the "REDEMPTION PRICE"). Company shall remit the Redemption Price
to the Holder in immediately available funds

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<Page>

within ten days of receiving written demand of such redemption. Upon Holder
receiving the Redemption Price, this Warrant, and the all rights of Holder under
this Warrant to purchase any Shares of the Company shall terminate.

4.  REPRESENTATIONS AND WARRANTIES OF HOLDER AND THE COMPANY.

(a) Representations and Warranties by Holder.  The Holder represents and
warrants to the Company with respect to this purchase as follows:

     (i)    The Holder has substantial experience in evaluating and investing in
     private placement transactions of securities of companies similar to the
     Company so that the Holder is capable of evaluating the merits and risks of
     its investment in the Company and has the capacity to protect its
     interests.

     (ii)   Except for transfers to a Holder's affiliates, the Holder is
     acquiring the Warrant and the Shares of Stock issuable upon exercise of the
     Warrant (collectively the "SECURITIES") for investment for its own account
     and not with a view to, or for resale in connection with, any distribution
     thereof. The Holder understands that the Securities have not been
     registered under the Securities Act of 1933, as amended (the "ACT") by
     reason of a specific exemption from the registration provisions of the Act
     which depends upon, among other things, the bona fide nature of the
     investment intent as expressed herein.

     (iii)  The Holder acknowledges that the Securities must be held
     indefinitely unless subsequently registered under the Act or an exemption
     from such registration is available. The Holder is aware of the provisions
     of Rule 144 promulgated under the Act.

     (iv)   The Holder is an "accredited investor" within the meaning of
     Regulation D promulgated under the Act.

     (v)    The Holder has had an opportunity to discuss the Company's business,
     management and financial affairs with its management and an opportunity to
     review the Company's facilities. The Holder understands that such
     discussions, as well as the written information issued by the Company, were
     intended to describe the aspects of the Company's business and prospects
     which the Company believes to be material but were not necessarily a
     thorough or exhaustive description.

(b) Company hereby represents and warrants to Holder that, except as set forth
in the schedule attached to this Warrant as EXHIBIT A (the "DISCLOSURE
SCHEDULE"), the statements in the following paragraphs of this Section 4(b) are
true and correct (x) as of the date hereof and (y) except where any such
representation and warranty relates specifically to an earlier date, as of the
date of any exercise of this Warrant.

            (i)    CORPORATE ORGANIZATION AND AUTHORITY. Company (a) is a
corporation duly organized, validly existing, and in good standing in its
jurisdiction of incorporation, (b) has the corporate power and authority to own
and operate its properties and to carry on its business as now conducted and as
proposed to be conducted; and (c) is qualified as a foreign corporation in all
jurisdictions where such qualification is required.

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<Page>

            (ii)   CORPORATE POWER.  Company has all requisite legal and
corporate power and authority to execute, issue and deliver the Warrant, to
issue the Common Stock issuable upon exercise or conversion of the Warrant, and
to carry out and perform its obligations under the Warrant and any related
agreements.

            (iii)  AUTHORIZATION; ENFORCEABILITY. All corporate action on the
part of Company, its officers, directors and shareholders necessary for the
authorization, execution, delivery and performance of its obligations under this
Warrant and for the authorization, issuance and delivery of the Warrant and
Stock issuable upon exercise of the Warrant has been taken and this Warrant
constitutes the legally binding and valid obligation of Company enforceable in
accordance with its terms.

            (iv)   VALID ISSUANCE OF WARRANT AND COMMON STOCK The Warrant has
been validly issued and is free of restrictions on transfer other than
restrictions on transfer set forth herein and under applicable state and federal
securities laws. The Common Stock issuable upon conversion of this Warrant, when
issued, sold and delivered in accordance with the terms of this Warrant for the
consideration expressed herein, will be duly and validly issued, fully paid and
nonassessable, and will be free of restrictions on transfer other than
restrictions on transfer under this Warrant and under applicable state and
federal securities laws. Subject to applicable restrictions on transfer, the
issuance and delivery of the Warrant and the Common Stock issuable upon
conversion of the Warrant are not subject to any preemptive or other similar
rights or any liens or encumbrances except as specifically set forth in
Company's Certificate of Incorporation or this Warrant. The offer, sale and
issuance of the Warrant and Common Stock, as contemplated by this Warrant, are
exempt from the prospectus and registration requirements of applicable United
States federal and state security laws, and neither Company nor any authorized
agent acting on its behalf has or will take any action hereafter that would
cause the loss of such exemption.

            (v)    NO CONFLICT WITH OTHER INSTRUMENTS. The execution, delivery,
and performance of this Warrant will not result in any violation of, be in
conflict with,

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<Page>

            or constitute a default under, with or without the passage of time
or the giving of notice (a) any provision of Company's Certificate of
Incorporation or by-laws; (b) any provision of any judgment, decree, or order to
which Company is a party or by which it is bound or an event which results in
the creation of any material lien, charge or encumbrance upon any material
assets of Company; (c) any contract, obligation, or commitment to which Company
is a party or by which it is bound; or (d) any statute, rule, or governmental
regulation applicable to Company.

            (vi)   CAPITALIZATION.  As of June 28, 2005 the authorized capital
stock of Company consists of 32,000,000 shares of Common Stock, $0.001 par
value, of which 993,032 were issued and outstanding, and 23,162,386 shares of
Preferred Stock, $0.001 par value, of which 22,907,015 were issued and
outstanding. The outstanding shares have been duly authorized and validly issued
(including, without limitation, issued in compliance with applicable federal and
state securities laws), are fully paid and nonassessable. Company has reserved
471 shares of Common Stock for issuance upon exercise of this Warrant. Except as
set forth in Section 4(b) of the Disclosure Schedule, there are no outstanding
warrants, options, conversion privileges, preemptive rights or other rights or
agreements to purchase or otherwise acquire or issue any equity securities or
convertible Securities of Company, nor has the issuance of any of the aforesaid
rights to acquire securities of Company been authorized.

           ( vii ) GOVERNMENTAL CONSENTS. No consent, approval, order or
authorization of, or registration, qualification, designation, declaration or
filing with, any federal, state or local governmental authority on the part of
Company is required in connection with the offer, sale or issuance of the
Warrant (and the Stock issuable upon the exercise of this Warrant), or the
consummation of any other transaction contemplated hereby, except for the
following: (a) the filing of a notice on Form D under the Act and b) the
compliance with other applicable state securities laws, which compliance will
have occurred within the appropriate time periods therefore. The offer, sale and
issuance of the Warrant and the shares of Stock in conformity with the terms of
this Warrant are exempt from the registration requirements of the Act and any
applicable state laws.

5.  LEGENDS.

(a) Each certificate representing the Securities shall be endorsed with the
following legend:

            THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
            OF 1933 AND MAY NOT BE TRANSFERRED UNLESS COVERED BY AN EFFECTIVE
            REGISTRATION STATEMENT UNDER SAID ACT, A "NO ACTION" LETTER FROM THE
            SECURITIES AND EXCHANGE COMMISSION WITH RESPECT TO SUCH TRANSFER, A
            TRANSFER MEETING THE REQUIREMENTS OF RULE 144 OF THE SECURITIES AND
            EXCHANGE COMMISSION, OR (IF REASONABLY REQUIRED BY THE COMPANY) AN
            OPINION OF COUNSEL SATISFACTORY TO THE ISSUER TO THE EFFECT THAT ANY
            SUCH TRANSFER IS EXEMPT FROM SUCH REGISTRATION.

The Company need not enter into its stock records a transfer of Securities
unless the conditions specified in the foregoing legend are satisfied. The
Company may also instruct its transfer agent

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not to allow the transfer of any of the Shares unless the conditions specified
in the foregoing legend are satisfied.

(b) REMOVAL OF LEGEND AND TRANSFER RESTRICTIONS. The legend relating to the Act
endorsed on a certificate pursuant to paragraph 5(a) of this Warrant shall be
removed and the Company shall issue a certificate without such legend to the
Holder of the Securities if (i) the Securities are registered under the Act and
a prospectus meeting the requirements of Section 10 of the Act is available or
(ii) the Holder provides to the Company an opinion of counsel for the Holder
reasonably satisfactory to the Company, a no-action letter or interpretive
opinion of the staff of the SEC reasonably satisfactory to the Company, or other
evidence reasonably satisfactory to the Company, to the effect that public sale,
transfer or assignment of the Securities may be made without registration and
without compliance with any restriction such as Rule 144.

6. CONDITION OF TRANSFER OR EXERCISE OF WARRANT. It shall be a condition to any
transfer or exercise of this Warrant that at the time of such transfer or
exercise, the Holder shall provide the Company with a representation in writing
that the Holder or transferee is acquiring this Warrant and the shares of Stock
to be issued upon exercise for investment purposes only and not with a view to
any sale or distribution. As a further condition to any transfer of this Warrant
or any or all of the shares of Stock issuable upon exercise of this Warrant,
other than a transfer registered under the Act, the Company may (if reasonably
required by the Company) request a legal opinion, in form and substance
satisfactory to the Company and its counsel, reciting the pertinent
circumstances surrounding the proposed transfer and stating that such transfer
is exempt from the registration and prospectus delivery requirements of the Act.
The Company shall not require Holder to provide an opinion of counsel if the
transfer is to an affiliate of or a special purpose entity formed by Holder.
Each certificate evidencing the shares issued upon exercise of the Warrant or
upon any transfer of the shares (other than a transfer registered under the Act
or pursuant to an exemption from registration or any subsequent transfer of
shares so registered) shall, at the Company's option, if the Shares are not
freely saleable under Rule 144(k) under the Act, contain a legend in form and
substance satisfactory to the Company and its counsel, restricting the transfer
of the shares to sales or other dispositions exempt from the requirements of the
Act. This Warrant may be transferred by the Holder, in whole or in part,
provided that, the Holder shall give the Company reasonable prior written notice
of any such proposed transfer and, if the Company demonstrates to the Holder's
reasonable satisfaction that the proposed transferee is a competitor of the
Company or the proposed transfer would otherwise result in the disclosure of
confidential Company information to such a competitor, then the Holder shall not
complete such transfer without the prior written consent of the Company. As
further condition to each transfer, at the request of the Company, the Holder
shall surrender this Warrant to the Company and the transferee shall receive and
accept a Warrant, of like tenor and date, executed by the Company.

7.  ADJUSTMENT FOR CERTAIN EVENTS. The number and kind of securities purchasable
upon the exercise of this Warrant and the Warrant Price shall be subject to
adjustment from time to time upon the occurrence of certain events, as follows:

(a) RECLASSIFICATION OR MERGER. In case of any reclassification or change of
securities of the class issuable upon exercise of this Warrant (other than a
change in par value, or from par value to no par value, or from no par value to
par value, or as a result of a subdivision or combination), or in case of any
merger of the Company with or into another corporation (other than a merger with

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another corporation in which the Company is the acquiring and the surviving
corporation and which does not result in any reclassification or change of
outstanding securities issuable upon exercise of this Warrant), or in case of
any sale of all or substantially all of the assets of the Company, the Company,
or such successor or purchasing corporation, as the case may be, shall duly
execute and deliver to the Holder a new Warrant (in form and substance
reasonably satisfactory to the Holder of this Warrant), or the Company shall
make appropriate provision without the issuance of a new Warrant, so that the
Holder shall have the right to receive, at a total purchase price not to exceed
that payable upon the exercise of the unexercised portion of this Warrant, and
in lieu of the shares of Stock theretofore issuable upon exercise of this
Warrant, the kind and amount of shares of stock, other securities, money and
property receivable upon such reclassification, change, merger or sale by a
Holder of the number of shares of Stock then purchasable under this Warrant, or
in the case of such a merger or sale in which the consideration paid consists
all or in part of assets other than securities of the successor or purchasing
corporation, at the option of the Holder, the securities of the successor or
purchasing corporation having a value at the time of the transaction equivalent
to the value of the Stock purchasable upon exercise of this Warrant at the time
of the transaction. Any new Warrant shall provide for adjustments that shall be
as nearly equivalent as may be practicable to the adjustments provided for in
this Section 7. The provisions of this subparagraph (a) shall similarly apply to
successive reclassifications, changes, mergers and transfers.

(b) SUBDIVISION OR COMBINATION OF SHARES. If the Company at any time while this
Warrant remains outstanding and unexpired shall (i) subdivide (by any stock
split, stock dividend, recapitalization or otherwise) its outstanding shares of
Common Stock into a greater number of shares, the Warrant Price in effect
immediately prior to such subdivision shall be proportionately decreased and the
number of Shares issuable hereunder shall be proportionately increased; or (ii)
combine (by reverse stock split or otherwise) its outstanding shares of Common
Stock into a smaller number of shares, the Warrant Price in effect immediately
prior to such combination shall be proportionately increased and the number of
Shares issuable hereunder shall be proportionately decreased.

(c) ISSUANCE OR DISTRIBUTION OF SHARES. (i) If at any time Company shall issue
or sell any additional Shares or common stock, other than as referred to in
Sections 7 (a) or (b) above, in exchange for consideration in an amount per
additional Share of Common Stock less than the Warrant Price at the time the
additional Shares of common stock are issued, then (A) the Warrant Price shall
be reduced to a price determined by dividing (x) an amount equal to the sum of
(1) the number of shares of common stock outstanding immediately prior to such
issuance or sale multiplied by the then existing Warrant Price, plus (2) the
consideration, if any, received by Company upon such issuance or sale, by (y)
the total number of shares of common stock outstanding immediately after such
issuance or sale; and (B) the number of shares of Common Stock for which this
Warrant is exercisable shall be adjusted to equal the product obtained by
multiplying the Warrant Price in effect immediately prior to such issuance or
sale by the number of shares of Common Stock for which this Warrant is
exercisable immediately prior to such issuance or sale and dividing the product
thereof by the Warrant Price resulting from the adjustment made pursuant to
clause (A) above.

     (ii) If at any time Company shall issue or sell any additional Shares of
Common Stock, other than referred to in Section 7 (a) or (b), for consideration
in an amount per additional Share of Common Stock less than the Fair Market
Value, then (A) the number of shares of Common

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Stock for which this Warrant is exercisable shall be adjusted to equal the
product obtained by multiplying the number of shares of Common Stock for which
this Warrant is exercisable immediately prior to such issuance or sale by a
fraction (x) the numerator of which shall be the number of shares of common
stock outstanding immediately after such issuance or sale, and (y) the
denominator of which shall be the sum of (1) the number of shares of common
stock outstanding immediately prior to such issuance or sale and (2) the number
of shares of common stock which the aggregate consideration, if any, received by
Company upon such issuance or sale would purchase at the then Fair Market Value;
and (B) the Warrant Price as to the number of shares of Common Stock for which
this Warrant is exercisable prior to such adjustment shall be adjusted by
multiplying such Warrant Price by a fraction (x) the numerator of which shall be
the number of shares of Common Stock for which this Warrant is exercisable
immediately prior to such issuance or sale; and (y) the denominator of which
shall be the number of shares of Common Stock for which this Warrant is
exercisable immediately after such issuance or sale

     (iii) If Company shall issue, sell, distribute or otherwise grant in any
manner any rights to subscribe for or to purchase, or any warrants or options
for the purchase of Common Stock or any stock or securities convertible into or
exchangeable for Commons Stock (such rights, warrants or options referred to as
"OPTIONS" and such convertible or exchangeable stock or securities referred to
as "CONVERTIBLE SECURITIES"), regardless of whether such Options or the rights
to convert or exchange any such Convertible Securities in respect of such
Options are immediately exercisable, and the price per share for which Common
Stock is issuable upon the exercise of such Options or upon conversion or
exchange of such Convertible Securities in respect of such Options shall be less
than the Warrant Price per share then in effect, or less than the Fair Market
Value of a share of Common Stock on a fully diluted basis on the date of
granting such Options (before giving effect to such grant), then, for purposes
of paragraph (i) or paragraph (ii) above (as applicable), the total maximum
number of shares of Common Stock issuable upon the exercise of such Options or
upon conversion or exchange of the total maximum amount such Convertible
Securities issuable upon the exercise of such Options shall be deemed to have
been issued as of the date of granting of such Options and thereafter shall be
deemed to be outstanding and Company shall be deemed to have received as
consideration of such price per Share. No additional adjustment shall be made
upon the actual exercise of such Options or upon conversion or exchange of such
Convertible Securities. For purposes of this paragraph (iii), the price per
Share for which Common Stock is issuable upon the exercise of such Options or
upon conversion or exchange of such Convertible Securities in respect of such
Options shall be determined by dividing (A) the aggregate amount, if any
received or receivable by Company as consideration for granting of such Options,
plus the minimum aggregate amount of additional consideration payable to Company
upon the exercise of all such Options, plus, in the case of Options to acquire
Convertible Securities, the minimum aggregate amount of additional consideration
, if any, payable upon the issuance or sale of such Convertible Securities and
upon the conversion or exchange there, by (B) the total maximum number of shares
of Common Stock issuable upon the exercise of such Options or upon the
conversion or exchange of all such Convertible Securities issuable upon the
exercise of such Options.

8.  NOTICE OF ADJUSTMENTS. Whenever any Warrant Price or the kind or number of
securities issuable under this Warrant shall be adjusted pursuant to Section 7
hereof, the Company shall prepare a certificate signed by an officer of the
Company setting forth, in reasonable detail, the event requiring the adjustment,
the amount of the adjustment, the method by which such adjustment was
calculated, and the Warrant Price and number or kind of shares issuable upon

                                      - 8 -
<Page>

exercise of the Warrant after giving effect to such adjustment, and shall cause
copies of such certificate to be mailed (by certified or registered mail, return
receipt required, postage prepaid) within thirty (30) days of such adjustment to
the Holder of this Warrant as set forth in Section 17 hereof.

9.  TRANSFERABILITY OF WARRANT. This Warrant is transferable on the books of the
Company at its principal office by the registered Holder hereof upon surrender
of this Warrant properly endorsed, subject to compliance with Section 6 and
applicable federal and state securities laws. The Company shall issue and
deliver to the transferee a new Warrant representing the Warrant so transferred.
Upon any partial transfer, the Company will issue and deliver to Holder a new
Warrant with respect to the Warrant not so transferred. Holder shall not have
any right to transfer any portion of this Warrant to any direct competitor of
the Company.

10. REGISTRATION RIGHTS The Company grants registration rights to the Holder of
this Warrant for any Common Stock of the Company obtained upon exercise of this
Warrant in parity to the registration rights granted to other holders of the
Common Stock and agrees that the Holder of this Warrant shall be added as a
party to that certain Investor Rights Agreement dated as of February 18, 2004 of
the Company (the "Registration Rights Agreement"), and that the Shares shall be
made "Registrable Securities" under the Registration Rights Agreement.

11. NO FRACTIONAL SHARES. No fractional share of Common Stock will be issued in
connection with any exercise hereunder, but in lieu of such fractional share the
Company shall make a cash payment therefor upon the basis of the Warrant Price
then in effect.

12. CHARGES, TAXES AND EXPENSES. Issuance of certificates for shares of Common
Stock upon the exercise of this Warrant shall be made without charge to the
Holder for any United States or state of the United States documentary stamp tax
or other incidental expense with respect to the issuance of such certificate,
all of which taxes and expenses shall be paid by the Company, and such
certificates shall be issued in the name of the Holder.

13.  NO SHAREHOLDER RIGHTS UNTIL EXERCISE.  This Warrant does not entitle the
Holder hereof to any voting rights or other rights as a shareholder of the
Company prior to the exercise hereof.

14. REGISTRY OF WARRANT. The Company shall maintain a registry showing the name
and address of the registered Holder of this Warrant. This Warrant may be
surrendered for exchange or exercise, in accordance with its terms, at such
office or agency of the Company, and the Company and Holder shall be entitled to
rely in all respects, prior to written notice to the contrary, upon such
registry.

15. LOSS, THEFT, DESTRUCTION OR MUTILATION OF WARRANT. Upon receipt by the
Company of evidence reasonably satisfactory to it of the loss, theft,
destruction or mutilation of this Warrant, and, in the case of loss, theft, or
destruction, of indemnity reasonably satisfactory to it, and, if mutilated, upon
surrender and cancellation of this Warrant, the Company will execute and deliver
a new Warrant, having terms and conditions substantially identical to this
Warrant, in lieu hereof.

16. Miscellaneous.

                                      - 9 -
<Page>

     (a)  ISSUE DATE. The provisions of this Warrant shall be construed and
     shall be given effect in all respect as if it had been issued and delivered
     by the Company on the date hereof.

     (b)  SUCCESSORS. This Warrant shall be binding upon any successors or
     assigns of the Company.

     (c)  GOVERNING LAW. This Warrant shall be governed by and construed in
     accordance with the internal laws of the State of Connecticut.

     (d)  HEADINGS. The headings used in this Warrant are used for convenience
     only and are not to be considered in construing or interpreting this
     Warrant.

     (e)  SATURDAYS, SUNDAYS, HOLIDAYS. If the last or appointed day for the
     taking of any action or the expiration of any right required or granted
     herein shall be a Saturday or a Sunday or shall be a legal holiday in the
     State of Connecticut, then such action may be taken or such right may be
     exercised on the next succeeding day not a legal holiday.

     (f)  WAIVER OF JURY TRIAL. Each of the parties hereto hereby waives to the
     fullest extent permitted by applicable law, any right it may have to a
     trial by jury in respect of any litigation directly or indirectly arising
     out of, under or in connection with this Warrant or the Shares.

     (g)  ATTORNEY'S FEES. In the event of any dispute between the parties
     concerning the terms and provisions of this Warrant, the party prevailing
     in such dispute shall be entitled to collect from the other party all costs
     incurred in such dispute, including reasonable attorney's fees.

17. NO IMPAIRMENT. The Company will not, by amendment of its Certificate of
Incorporation or any other voluntary action, avoid or seek to avoid the
observance or performance of any of the terms of this Warrant, but will at all
times in good faith assist in the carrying out of all such terms and in the
taking of all such action as may be necessary or appropriate in order to protect
the rights of the Holder hereof against impairment.

18. ADDRESSES. Any notice required or permitted hereunder shall be in writing
and shall be mailed by overnight courier, registered or certified mail, return
receipt required, and postage prepaid, or otherwise delivered by hand or by
messenger, addressed as set forth below, or at such other address as the Company
or the Holder hereof shall have furnished to the other party.

                  If to the Company:     COMBINATORX, INCORPORATED
                                         650 Albany Street
                                         Boston, MA 02118
                                         Attn: Robert Forrester

                  If to the Holder:      GENERAL ELECTRIC CAPITAL CORPORATION
                                         83 Wooster Heights Road
                                         Danbury, CT 06810
                                         Attn: Credit Manager

                                     - 10 -
<Page>

     IN WITNESS WHEREOF, CombinatoRx, Incorporated has caused this Warrant to be
executed by its officers thereunto duly authorized.

Dated as of June 28, 2005.

                                        By:     /s/ Robert Forrester
                                            ------------------------------------

                                        Name:       Robert Forrester
                                              ----------------------------------

                                        Title:     Chief Financial Officer
                                               ---------------------------------

                                     - 11 -
<Page>

NOTICE OF EXERCISE
TO:

     The undersigned Warrant holder ("HOLDER") elects to acquire shares of Stock
(the "COMMON STOCK") of _____________________, (the "COMPANY"), pursuant to the
terms of the Stock Purchase Warrant dated _____ __, 2005 (the "WARRANT").

1.  The Holder exercises its rights under the Warrant as set forth below:

            (     )     The Holder elects to purchase _____________ shares of
                        Common Stock as provided in Section 3(a) and tenders
                        herewith a check in the amount of $___________ as
                        payment of the purchase price.

            (     )     The Holder elects to convert the purchase rights into
                        shares of Common Stock as provided in Section 3(b) of
                        the Warrant.

2.  The Holder surrenders the Warrant with this Notice of Exercise.

The Holder represents that it is acquiring the aforesaid shares of Common Stock
for investment and not with a view to or for resale in connection with
distribution and that the Holder has no present intention of distributing or
reselling the shares.

Please issue a certificate representing the shares of the Common Stock in the
name of the Holder or in such other name as is specified below:

            Name:
            Address:

            Taxpayer I.D.:
                                          ------------------------------------
                                          (Holder)

                                          By:
                                              ----------------------------------

                                          Title:
                                                 -------------------------------

                                          Date:
                                                 -------------------------------

<Page>

                       OPTIONAL OR ALTERNATIVE PROVISIONS

10. "PIGGYBACK" REGISTRATION RIGHTS.

(a) Subject to Section 10(b) through 10(d) below, if the Company shall determine
to proceed with the preparation and filing of a registration statement under the
Act in connection with the proposed offer and sale of any of its securities by
it or any of its security holders (other than registrations effected to
implement an employee benefit plan, a transaction to which Rule 145 or any other
similar rule is applicable, or a registration in which the only Common Stock
being registered is Common Stock issuable upon conversion of debt securities
that are also being registered), the Company will give written notice of its
determination to the Holder. Upon the written request from the Holder, within
twenty (20) days after receipt of any such notice from the Company (and receipt
by the Company of any information from the Holder which is required to be
included in a registration statement), the Company will, except as provided in
this Section 10 and at the Company's expense (except as provided below), cause
all shares of the Company's Common Stock issuable upon the exercise of this
Warrant to be included in such registration statement, all to the extent
requisite to permit the sale or other disposition by the prospective seller or
sellers of the securities to be so registered; provided, further, that nothing
herein or otherwise shall prevent the Company from, at any time, abandoning or
delaying any registration without any obligation to the Holder. If any
registration shall be underwritten in whole or in part, (i) the Company may
require that the securities requested for inclusion pursuant to this section be
included in the underwriting on the same terms and conditions as the securities
otherwise being sold through the underwriters and (ii) the Company shall not be
required to include any such securities in such underwriting unless the Holder
thereof accepts the terms of the underwriting.

(b) Notwithstanding the foregoing, if the managing underwriter in an
underwritten offering determines and advises in writing that marketing factors
require a limitation of the number of shares to be underwritten, then the number
of such shares that the managing underwriter believes may be sold in such
underwritten public offering shall be allocated for inclusion in any
registration statement in the following order of priority: (i) the securities
being offered by the Company; (ii) the securities being offered by the Investors
(as such term is defined in Section 10(c) below); (iii) the securities being
sought to be registered by the Holder of this Warrant; and (iv) all others not
in (i) through (iii) above.

(c) As used herein, the term "Investors" shall mean (i) holders of any class or
series of the Company's preferred stock and any shares of common stock into
which such preferred stock has been or will be converted, (ii) holders of shares
of the Company's common stock issued upon exercise of warrants issued in
connection with the sale of any shares of the Company's capital stock and (iii)
holders of shares of the Company's stock issued in connection with all other
equity offerings of the Company.

(d) The rights granted to the Holder under this Section 10 shall terminate on
the date that is five (5) years from the closing date of the Company's initial
public offering or such earlier time at

                                     - 13 -
<Page>

which all the shares of Common Stock issued pursuant to the exercise of this
Warrant can be sold by in a single three (3) month period pursuant to Rule 144
under the Act.

(e) In the event of a registration described above, all reasonable expenses of
registration and offering of the Company and the holders participating in the
offering including, without limitation, all registration, qualification and
filing fees, printing expenses, escrow fees, fees and disbursements of counsel
for the Company, blue sky fees and expenses, the expense of any special audits
incident to or required by any such registration and the expenses of one counsel
for the holders, shall be borne by the Company, except that holders shall bear
underwriting discounts, selling commissions and stock transfer taxes applicable
to the securities registered by the holders.

(f) Holder and each transferee pursuant to Sections 6 and 9 agrees, in
connection with the first registration of the Company's securities in an
underwritten public offering, to the extent requested by the managing
underwriter, that it shall not, without the prior consent of the Company or the
underwriters managing any underwritten offering of the Company's securities,
sell, make any short sale of, loan, grant any option for the purchase of, or
otherwise dispose of any of the shares of Common Stock issued pursuant to the
exercise of this Warrant (other than those included in the registration), as the
case may be, for a period of time specified by the managing underwriter up to
one hundred eighty (180) days from the effective date of such registration.
Holder agrees that the Company may instruct its transfer agent to place stop
transfer notations in its records to enforce the provisions of this Section
10(f).

(g) In the event of a registration as described above, the Company and Holder
will agree to indemnify each other, and each other's respective directors and
officers, legal counsel and accountants, with respect to the inaccuracy of
information included in such registration or any related prospectus with respect
to the Company or Holder, as the case may be, on terms and in such manner as are
customary.
The rights granted to the Holder under this Section 10 are not intended to
create any registration rights or other rights senior to or on parity with those
rights of the holders of any class or series of the Company's preferred stock.

                                     - 14 -

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