Document:

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                                                                   Exhibit 10.8

                             SECURED PROMISSORY NOTE

                                                                 March 31, 2000

$104,000.00

         For value received, the undersigned, Stanley N. Lapidus, (the
"OBLIGOR"), hereby promises to pay to the order of Exact Laboratories, Inc., a
Delaware corporation (the "COMPANY") or its registered assigns, at the Company's
principal office at 63 Great Road, Maynard, Massachusetts 01754 or at such other
place as may be designated from time to time in writing by Company, the
principal sum of One Hundred Four Thousand Dollars and No Cents ($104,000.00)
together with interest in arrears from and including the date hereof on the
unpaid principal balance hereunder, computed daily, at the rate of 9% per annum,
payable as set forth below. At the option of Company and to the extent permitted
by applicable law, the rate of interest on any unpaid principal or interest not
paid when due and payable hereunder shall be two percent (2%) per annum above
the rate of interest set forth in the immediately preceding sentence. Interest
shall be calculated on the basis of actual number of days elapsed over a year of
360 days. Notwithstanding any other provision of this Promissory Note, the
Company does not intend to charge and Obligor shall not be required to pay any
interest or other fees or charges in excess of the maximum permitted by
applicable law; any payments in excess of such maximum shall be refunded to
Obligor or credited to reduce principal hereunder. All payments received by
Company hereunder will be applied first to costs of collection, if any, then to
interest and the balance to principal. Principal and interest shall be payable
in lawful money of the United States of America.
         120 payments of $780.00 accrued interest only shall be paid on the last
Thursday of each month beginning in April, 2000, until March 31, 2010 at which
time the final payment of outstanding principal and accrued interest thereon
shall be due and payable in full, if not sooner paid; PROVIDED, HOWEVER, (i) if
Obligor's employment with the Company is terminated at any time for any or no
reason, the principal (plus accrued interest) shall be immediately due and
payable upon the effective date of such termination, or (ii) if the Company
effects a registration of it's capital stock in an initial public offering under
the Securities Act of 1933, as amended (an "IPO"),

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then the principal (plus accrued interest) shall be due and payable within 2
years following the effective date of the Registration Statement filed with the
Securities and Exchange Commission effecting the IPO. Payments of principal plus
interest shall be paid through payroll deductions from Obligor's wages from the
Company.
         If any day on which a payment is due pursuant to the terms of this
Promissory Note is not a day on which banks in the Commonwealth of Massachusetts
are generally open (a "BUSINESS DAY"), such payment shall be due on the next
Business Day following.
         This Promissory Note may be prepaid at any time, without premium or
penalty, in whole or in part, all such prepayments to be applied upon
installments of most remote maturity. Any prepayment of principal shall be
accompanied by a payment of accrued interest in respect of the principal being
prepaid.
         This Promissory Note is secured by and entitled to the benefits of a
Pledge Agreement between Obligor and Company of even date herewith (the "PLEDGE
AGREEMENT"). Upon the occurrence of any Event of Default, as defined below,
Company may declare any or all obligations or liabilities of Obligor to Company
(including the unpaid principal hereunder and any interest due thereon),
immediately due and payable without presentment, demand, protest or notice.
         This Promissory Note shall, at the option of the holder hereof, become
due and payable without notice or demand, upon the happening of any one of the
following specified events by or with respect to the Obligor or any guarantor
of this Promissory Note (each an "EVENT OF DEFAULT"): (1) failure to pay any
amount as herein set forth; (2) default in the performance of any other
obligation to Company, which default is not cured within thirty (30) days after
written notice of such default from Company; (3) insolvency (however evidenced)
or the commission of any act of insolvency; (4) the making of a general
assignment for the benefit of creditors; (5) the filing of any petition or the
commencement of any proceeding for any relief under any bankruptcy or insolvency
laws, or any laws relating to the relief of debtors, readjustment of
indebtedness, reorganizations, compositions, or extensions; (6) the filing of
any petition or the commencement of any proceeding for any relief under any
bankruptcy or insolvency laws, or any laws relating to the relief of debtors,
readjustment of indebtedness, reorganizations, compositions, or extensions,
which proceeding is not dismissed within sixty (60) days; (7) suspension of the
transaction of the usual business of Obligor; or (8) the past or future making
of a false representation or warranty by Obligor in connection with any loan or
loans by Company.

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                                      -3-

        Any deposits or other sums at any time credited by or due from Company
to or for Obligor and any securities or other property of Obligor in the
possession of Company shall at all times be held and treated as collateral
security for the payment of this Promissory Note and any other liability now
existing or hereafter arising of Obligor to Company and Company may apply or set
off any such deposits and sums against said liabilities.
         If this Promissory Note is not paid in accordance with its terms,
Obligor shall pay to Company, in addition to principal and accrued interest
thereon, all costs of collection of the principal and accrued interest,
including, but not limited to, reasonable attorneys' fees, court costs and
other costs for the enforcement of payment of this Promissory Note.
         No waiver of any obligation of Obligor under this
Promissory Note shall be effective unless it is in a writing signed by Company.
A waiver by Company of any right or remedy under this Promissory Note on any
occasion shall not be a bar to exercise of the same right or remedy on any
subsequent occasion or of any other right or remedy at any time.
         Any notice required or permitted under this Promissory Note shall be in
writing and shall be deemed to have been given on the date of delivery, if
personally delivered to the party to whom notice is to be given, or on the fifth
business day after mailing, if mailed to the party to whom notice is to be
given, by certified mail, return receipt requested, postage prepaid, and
addressed to the addressee at the address of the addressee set forth herein, or
to the most recent address, specified by written notice, given to the sender
pursuant to this paragraph.
         This Promissory Note is delivered in and shall be enforceable in
accordance with the laws of the Commonwealth of Massachusetts, and shall be
construed in accordance therewith, and shall have the effect of a sealed
instrument.
         Obligor hereby expressly waives presentment, demand, and protest,
notice of demand, dishonor and nonpayment of this Promissory Note, and all other
notices or demands of any kind in connection with the delivery, acceptance,
performance, default or enforcement hereof, and hereby consents to any delays,
extensions of time, renewals, waivers or modifications that may be granted or
consented to by the holder hereof with respect to the time of payment or any
other provision hereof or of the Pledge Agreement.

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                                      -4-

        In the event any one or more of the provisions of this Promissory Note
shall for any reason be held to be invalid, illegal or unenforceable, in whole
or in part or in any respect, or in the event that any one or more of the
provisions of this Promissory Note operate or would prospectively operate to
invalidate this Promissory Note, then and in any such event, such provision(s)
only shall be deemed null and void and shall not affect any other provision of
this Promissory Note and the remaining provisions of this Promissory Note shall
remain operative and in full force and effect and in no way shall be affected,
prejudiced, or disturbed thereby.

                                    OBLIGOR:

                                   /s/ Stanley N. Lapidus
                                   ------------------------
                                    Signature

                                   STANLEY N. LAPIDUS
                                   ------------------------
                                    Print Name<PAGE>

                                                                Exhibit 10.9

                                PLEDGE AGREEMENT

         PLEDGE AGREEMENT, dated as of March 31, 2000, made by the undersigned
(the "BORROWER"), in favor of Exact Laboratories, Inc., a Delaware corporation
with its Principal Office at 63 Great Road, Maynard, Massachusetts 01754 (the
"COMPANY").

                                    RECITALS

         WHEREAS, pursuant to the Company's 1995 Stock Plan the Company has
granted to Borrower options to purchase an aggregate 100,000 shares of the
Company's Common Stock, $0.01 par value per share, (the "SHARES"), of which
75,000 shares are subject to restrictions on transfer pursuant to a Stock
Restriction Agreement by and between the Borrower and the Company dated March
31, 2000 (the "STOCK RESTRICTION AGREEMENT");

         WHEREAS, the Company has agreed to make a loan to the Borrower upon the
terms and subject to the conditions set forth therein, to be evidenced by the
promissory note (the "NOTE") issued by the Borrower thereunder; and

         WHEREAS, the Borrower is the legal and beneficial owner of the Pledged
Securities (as hereinafter defined) and it is a requirement of the Borrower
under the Stock Restriction Agreement that the Borrower shall execute and
deliver this Pledge Agreement to the Company.

         NOW, THEREFORE, in consideration of the premises, the Borrower hereby
agrees with the Company as follows:

         1. DEFINED TERMS. Unless otherwise defined herein, terms which are
defined in the Credit Agreement and used herein are so used as so defined, and
the following terms shall have the following meanings:

         "CODE" means the Uniform Commercial Code from time to time in effect in
the Commonwealth of Massachusetts.

         "COLLATERAL" means the Pledged Securities and all Proceeds.

         "EVENT OF DEFAULT" means those events set forth in the Note.

         "OBLIGATIONS" means the unpaid principal of and interest on the Note
and all other obligations and liabilities of the Borrower to the Company,
whether direct or indirect, absolute or contingent, due or to become due, or now
existing or hereafter incurred, which may arise under, out of, or in connection
with, the Stock Restriction Agreement, the Note or this Pledge Agreement and any
other document made, delivered or given in connection therewith or herewith,
whether on account of principal, interest, reimbursement obligations, fees,
indemnities, costs, expenses (including, without limitation, all reasonable fees
and disbursements of counsel to the Company) or otherwise.

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                                      -2-

         "PERMITTED LIENS" means the right of the Company to repurchase the
Pledged Securities under certain circumstances pursuant to the Restricted Stock
Purchase Agreement between the Company and the Borrower dated March 31, 2000.

         "PLEDGE AGREEMENT" means this Pledge Agreement, as amended,
supplemented or otherwise modified from time to time.

         "PLEDGED SECURITIES" means the Shares, together with all stock
certificates, instruments, options or rights of any nature whatsoever which may
be issued or granted to the Borrower in respect of the Pledged Securities, while
this Pledge Agreement in effect.

         "PROCEEDS" means all "proceeds" as such term is defined in Section
9-306(1) of the Code and, in any event, shall include, without limitation, all
dividends or other income from the Pledged Securities, collections thereon or
distributions with respect thereto.

         2. PLEDGE; GRANT OF SECURITY INTEREST. The Borrower hereby delivers to
the Company all the Pledged Securities and hereby grants to the Company a first
security interest in the Collateral, as collateral security for the prompt and
complete payment and performance when due (whether at the stated maturity, by
acceleration or otherwise) of the Obligations.

         3. STOCK POWERS. Concurrently with the delivery to the Company of each
certificate or instrument representing the Pledged Securities, the Borrower
shall deliver an undated stock power or other transfer document covering such
certificate or instrument, duly executed in blank with, if the Company so
requests, signature guaranteed.

         4. REPRESENTATIONS AND WARRANTIES. The Borrower represents and warrants
to the Company that:

                  (a) the Borrower is the record and beneficial owner of, and
has good and marketable title to, the Pledged Securities, free of any and all
security interests, liens or options in favor of, or claims of, any other person
or entity, except for Permitted Liens; and

                  (b) upon delivery to the Company of the certificates and
instruments evidencing the Pledged Securities, the lien granted pursuant to this
Pledge Agreement will constitute a valid, perfected first priority lien on the
Pledged Securities enforceable as such against all creditors of the Borrower and
any person or entities purporting to purchase any Collateral from the Borrower.

         5. COVENANTS. The Borrower covenants and agrees with the Company that,
from and after the date of this Pledge Agreement until the Obligations are paid
in full:

                  (a) If the Borrower shall, as a result of its ownership of the
Pledged Securities, become entitled to receive or shall receive any stock
certificate or other certificate or instrument (including, without limitation,
any certificate representing a stock dividend or a distribution in connection
with any reclassification, increase or reduction of capital or any certificate
or

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                                      -3-

instrument issued in connection with any reorganization), option or rights,
whether in addition to, in substitution of, as a conversion of, or in exchange
for any of the Pledged Securities or otherwise in respect thereof, the Borrower
shall accept the same as the Company's agent, hold the same in trust for the
Company and deliver the same forthwith to the Company in the exact form
received, together with an undated stock power or other transfer document
covering such certificate or instrument duly executed in blank and with, if the
Company so requests, signature guaranteed, to be held by the Company hereunder
as additional collateral security for the Obligations. Any sums paid upon or in
respect of the Pledged Securities upon the liquidation or dissolution of the
issuer thereof shall be paid over to the Company to be held by it hereunder as
additional collateral security for the Obligations, and in case any distribution
of capital shall be made on or in respect of the Pledged Securities or any
property shall be distributed upon or with respect to the Pledged Securities
pursuant to the recapitalization or reclassification of the capital of the
issuer thereof or pursuant to the reorganization thereof, the property so
distributed shall be delivered to the Company to be held by it, subject to the
terms hereof, as additional collateral security for the Obligations. If any sums
of money or property so paid or distributed in respect of the Pledged Securities
shall be received by the Borrower, the Borrower shall, until such money or
property is paid or delivered to the Company, hold such money or property in
trust for the Company, segregated from other funds of the Borrower, as
additional collateral security for the Obligations.

                  (b) Without the prior written consent of the Company, the
Borrower will not (i) sell, assign, transfer, exchange or otherwise dispose of,
or grant any option with respect to, the Collateral except in compliance with
the provisions of Sections 6, 8 and 9 of the Stock Restriction Agreement, or
(ii) create, incur or permit to exist any lien or option in favor of, or any
claim of any person or entity with respect to, any of the Collateral, or any
interest therein, except for Permitted Liens. The Borrower will defend the
right, title and interest of the Company in and to the Collateral against the
claims and demands of all person or entities whomsoever.

                  (c) At any time and from time to time, upon the written
request of the Company, and at the sole expense of the Borrower, the Borrower
will promptly and duly execute and deliver such further instruments and
documents and take such further actions as the Company may reasonably request
for the purposes of obtaining or preserving the full benefits of this Pledge
Agreement and of the rights and powers herein granted. If any amount payable
under or in connection with any of the Collateral shall be or become evidenced
by any promissory note, other instrument or chattel paper, such note, instrument
or chattel paper shall be promptly delivered to the Company, duly endorsed in a
manner satisfactory to the Company, to be held as Collateral pursuant to this
Pledge Agreement.

                  (d) The Borrower agrees to pay, and to save the Company
harmless from, any and all liabilities with respect to, or resulting from any
delay in paying any and all stamp, excise, sales or other taxes (exclusive of
taxes based on income, gross receipts, franchise rights and related items) which
may be payable or determined to be payable with respect to any of the Collateral
or in connection with any of the transactions contemplated by this Pledge
Agreement.

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                                      -4-

         6. CASH DIVIDENDS; VOTING RIGHTS. Notwithstanding the provisions of
Section 5(a) hereof, unless an Event of Default shall have occurred, the
Borrower shall be permitted to receive all cash dividends and other cash
distributions paid by the issuer of any of the Pledged Securities in respect of
the Pledged Securities and to exercise all voting and corporate rights with
respect to the Pledged Securities, PROVIDED, HOWEVER, that after written notice
from the Company to the Borrower, no stockholder vote shall be cast or corporate
right exercised or other action taken by the Borrower which, in the Company's
reasonable judgment, would impair the Collateral or which would be inconsistent
with or result in any violation of any provision of the Credit Agreement, the
Note or this Pledge Agreement, except if and to the extent that the Borrower is
obligated to effect such vote, exercise or action pursuant to an agreement
between the Borrower and one or more third parties.

         7. RIGHTS OF THE COMPANY. (a) If an Event of Default shall occur and be
continuing: (i) the Company shall have the right to receive any and all cash
dividends paid in respect of the Pledged Securities and make application thereof
to the Obligations in such order as it may determine, and (ii) all of the
Pledged Securities shall be registered in the name of the Company or its
nominee, and the Company or its nominee may thereafter exercise (A) all voting,
corporate, and other rights pertaining to the Pledged Securities at any meeting
or otherwise and (B) any and all rights of conversion, exchange, subscription
and any other rights, privileges or options pertaining to such Pledged
Securities as if it were the absolute owner thereof (including, without
limitation, the right to exchange at its discretion any and all of the Pledged
Securities upon the merger, consolidation, reorganization, recapitalization of
other fundamental change in the corporate or partnership structure of the issuer
thereof or upon the exercise by the Borrower or the Company of any right,
privilege or option pertaining to such Pledged Securities and in connection
therewith, the right to deposit and deliver any and all of the Pledged
Securities with any committee, depository, transfer agent, registrar or other
designated agency upon such terms and conditions as it may determine), all
without liability except to account for property actually received by it, but
the Company shall have no duty to exercise any such right, privilege or option
and shall not be responsible for any failure to do so or delay in so doing.

                  (b) The rights of the Company hereunder shall not be
conditioned or contingent upon the pursuit by the Company of any right or remedy
against the Borrower or against any other person or entity which may be or
become liable in respect of all or any part of the Obligations or against any
other collateral security therefor, guarantee thereof or right of offset with
respect thereto. The Company shall not be liable for any failure to demand,
collect or realize upon all or any part of the Collateral or for any delay in
doing so, nor shall it be under any obligation to sell or otherwise dispose of
any Collateral upon the request of the Borrower or any other person or entity or
to take any other action whatsoever with regard to the Collateral or any part
thereof.

         8. REMEDIES. If an Event of Default shall occur and be continuing, the
Company may exercise, in addition to all other rights and remedies granted in
this Pledge Agreement and in any other instrument or agreement securing,
evidencing or relating to the Obligations, all rights and remedies of a secured
party under the Code. Without limiting the generality of the foregoing, the
Company, without demand of performance or other demand, presentment, protest,

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                                      -5-

advertisement or notice of any kind (except any notice required by law referred
to below) to or upon the Borrower, any guarantor or any other person or entity
(all and each of which demands, defenses, advertisements and notices are hereby
expressly waived), may in such circumstances forthwith collect, receive,
appropriate and realize upon the Collateral, or any part thereof, and/or may
forthwith sell, assign, give option or options to purchase or otherwise dispose
of and deliver the Collateral or any part thereof (or contract to do any of the
foregoing), in one or more parcels at public or private sale or sales, in the
over-the-counter market, at any exchange, broker's board or office of the
Company or elsewhere upon such terms and conditions as it may deem advisable and
at such prices as it may deem best, for cash or on credit or for future delivery
without assumption of any credit risk. The Company shall have the right upon any
such public sale or sales, and, to the extent permitted by law, upon any such
private sale or sales, to purchase the whole or any part of the Collateral so
sold, free of any right or equity of redemption in the Borrower, which right or
equity is hereby expressly waived and released. The Company shall apply any
Proceeds from time to time held by it and the net proceeds of any such
collection, recovery, receipt, appropriation, realization or sale, after
deducting all reasonable costs and expenses of every kind incurred therein or
incidental to the care or safekeeping of any of the Collateral or in any way
relating to the Collateral or the rights of the Company hereunder, including,
without limitation, reasonable attorneys' fees and disbursements, to the payment
in whole or in part of the Obligations, in such order as the Company may elect,
and only after such application and after the payment by the Company of any
other amount required by any provision of law, including, without limitation,
Section 9-504(1)(c) of the Code, need the Company account for the surplus, if
any, to the Borrower. To the extent permitted by applicable law, the Borrower
waives all claims, damages and demands it may acquire against the Company
arising out of the exercise by the Company of any of its rights hereunder. If
any notice of a proposed sale or other disposition of Collateral shall be
required by law, such notice shall be deemed reasonable and proper if given at
least ten (10) days before such sale or other disposition.

         9. AMENDMENTS WITH RESPECT TO THE OBLIGATIONS. The Borrower shall
remain obligated hereunder, and the Collateral shall remain subject to the lien
granted hereby, notwithstanding that, without any reservation of rights against
the Borrower, and without notice to or further assent by the Borrower, any
demand for payment of any of the Obligations made by the Company may be
rescinded by the Company, and any of the Obligations continued, and the
Obligations, or the liability of the Borrower upon or for any part thereof, or
any collateral security or guarantee therefor or right of offset with respect
thereto, may, from time to time, in whole or in part, be renewed, extended,
amended, modified, accelerated, compromised, waived, surrendered or released by
the Company, and the Credit Agreement, Note and any other document in connection
therewith may be amended, modified, supplemented or terminated, in whole or in
part, as the Company may deem advisable from time to time, and any right of
offset or other collateral at any time held by the Company for the payment of
the Obligations may be sold, exchanged, waived, surrendered or released. The
Company shall have no obligation to protect, secure, perfect or insure any other
lien at any time held by it as security for the Obligations or any property
subject thereto. The Borrower hereby expressly waives any and all notice of the
creation, renewal, extension or accrual of any of the Obligations and notice of
or proof of reliance by the Company upon this Pledge Agreement; the Obligations,
and any of them, shall conclusively be deemed to have been created, contracted
or incurred in reliance upon this

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                                      -6-

Pledge Agreement; and all dealings between the Borrower and the Company shall
likewise be conclusively presumed to have been created or consummated in
reliance upon this Pledge Agreement. The Borrower hereby expressly waives
diligence, presentment, protest, demand for payment and notice of default or
nonpayment to or upon the Borrower with respect to the Obligations.

         10. LIMITATION ON DUTIES REGARDING COLLATERAL. The Company's sole duty
with respect to the custody, safekeeping and physical preservation of the
Collateral in its possession, under Section 9-207 of the Code or otherwise,
shall be to deal with it in the same manner as the Company deals with similar
securities, instruments and property for its own account. Neither the Company
nor any of its directors, officers, employees or agents shall be liable for
failure to demand, collect or realize upon any of the Collateral or for any
delay in doing so or shall be under any obligation to sell or otherwise dispose
of any Collateral upon the request of the Borrower or otherwise.

         11. POWERS COUPLED WITH AN INTEREST. All authorizations and agencies
herein contained with respect to the Collateral are irrevocable and powers
coupled with an interest.

         12. SEVERABILITY. Any provision of this Pledge Agreement which is
prohibited or unenforceable in any jurisdiction shall, as to such jurisdiction,
be ineffective to the extent of such prohibition or unenforceability without
invalidating the remaining provisions hereof, and any such prohibition or
unenforceability in any jurisdiction shall not invalidate or render
unenforceable such provision in any other jurisdiction.

         13. SECTION HEADINGS. The paragraph headings used in this Pledge
Agreement are for convenience of reference only and are not to affect the
construction hereof or to be taken into consideration in the interpretation
hereof.

         14. NO WAIVER; CUMULATIVE REMEDIES. The Company shall not by any act
(except by a written instrument pursuant to paragraph 15 hereof), delay,
indulgence, omission or otherwise be deemed to have waived any right or remedy
hereunder or to have acquiesced in any default or Event of Default or in any
breach of any of the terms and conditions hereof. No failure to exercise, nor
any delay in exercising, on the part of the Company, any right, power or
privilege hereunder shall operate as a waiver thereof. No single or partial
exercise of any right, power or privilege hereunder shall preclude any other or
further exercise thereof or the exercise of any other right, power or privilege.
A waiver by the Company of any right or remedy hereunder on any one occasion
shall not be construed as a bar to any right or remedy which the Company would
otherwise have on any future occasion. The rights and remedies herein provided
are cumulative, may be exercised singly or concurrently and are not exclusive of
any rights or remedies provided by law.

         15. WAIVERS AND AMENDMENTS; SUCCESSORS AND ASSIGNS; GOVERNING LAW. None
of the terms or provisions of this Pledge Agreement, may be waived, amended,
supplemented or otherwise modified except by a written instrument executed by
the Borrower and the Company, PROVIDED that any provision of this Pledge
Agreement may be waived in writing by the Company

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                                      -7-

in a letter or agreement executed by the Company or by telex or facsimile
transmission from the Company. This Pledge Agreement shall be binding upon the
successors and assigns of the Borrower and shall inure to the benefit of the
Company and its successors and assigns. This Pledge Agreement shall be governed
by, and construed and interpreted in accordance with, the laws of the
Commonwealth of Massachusetts.

         16. NOTICES. Notices by either party hereto to the other shall be given
as provided in the Credit Agreement.

         17. COUNTERPARTS. This Pledge Agreement may be executed in several
counterparts, each of which shall constitute an original, but all of which, when
taken together, shall constitute but one agreement.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]

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                                      -8-

         IN WITNESS WHEREOF, the undersigned has caused this Pledge Agreement to
be duly executed and delivered as of the date first above.

                                                  BORROWER:

                                                  /s/ Stanley N. Lapidus
                                                  ----------------------------
                                                  Signature

                                                  STANLEY N. LAPIDUS
                                                  ----------------------------
                                                  Print Name

                                                  COMPANY:

                                                  EXACT LABORATORIES, INC.

                                                  By: /s/ Stanley N. Lapidus
                                                      ------------------------

                                                  Title: President
                                                         ---------------------

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