Document:

Exhibit 10.46

 

	
Confidential   Treatment Requested
   Under 17 C.F.R. §§ 200.80(b)(4) and
   240.24b-2
    	

    

 

CHANGE ORDER

 

AMENDED LETTER OF PAYMENT AUTHORIZATION

 

Amendment No. 01

 

January 20th, 2012

 

Gary Hattersley, Ph.D.

Vice President, Biology

RADIUS HEALTH, INC.

5th Floor

300 Technology Square

Cambridge, MA 02139

United States

ghattersley@radiuspharm.com

 

	
RE:
    	
 
    	
STUDY   PN 670364
    (Radius No:10RAD032)
    	
 
    	
Study   Title: A 2-Year Subcutaneous Injection Carcinogenicity   Study Of BA058 And PTH In The Fisher 344 Rat
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
AS PER   FINAL PROTOCOL DATED:      December 29, 2010

AS   PER PROTOCOL AMENDMENT # 1, 2 and 5

 

STUDY   START: Week of January 17, 2010
    

 

Dear Gary,

 

This communication is to serve as an Amended Letter of Payment Authorization (ALOPA) for the above referenced study, which will be performed at Charles River Laboratories Preclinical Services as set forth below.  Charles River Laboratories Preclinical Services shall perform these services in accordance with the existing Service Agreement executed between Charles River Laboratories Preclinical Services and RADIUS HEALTH, INC. Once fully executed, this ALOPA shall be incorporated into and made part of the existing Service Agreement.

 

Summary of Changes:

 

· 48 animals added for TK population

· Blood smear evaluation added

· 1 time point of TK removed

· TK analysis removed

· Histopathology on TK animals removed

· 7 tissues added for histopathology

· ADA sampling added

· 5 occasions of dose analysis added

· 30 spare animals removed

· Acclimation extended by 1 week

· Pharmacy preparation modified

· Organ weight report removed

· PTH 1-34 analysis added for Group 5 sample

 

[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

 

1

 

The price of this Protocol Amendment is as follows:

 

	
Authorized   Price

(After   discount)
    	
 
    	
$ [*]

(as   per signed LOPA dated: November 16, 2010)
    
	
 
    	
 
    	
 
    
	
Additional   Charge
    	
 
    	
$ [*]
    
	
 
    	
 
    	
 
    
	
Additional   with additional [*]% goodwill discount:
    	
 
    	
$ [*]
    
	
 
    	
 
    	
 
    
	
Revised   Price
    	
 
    	
$ 2,489,035 US
    

 

The payment schedules of this study are as follows:

 

·$ [*] First payment at study authorization

·75% Equal monthly installments

·Additional Charge  Due upon receipt of invoice

·5% Upon receipt of draft report

·5% Upon receipt of final report or forty five (45) days after issuance of draft report (whichever comes first)

 

Please sign and return this document via facsimile or email (contact information below).  Should you have any questions or require any additional information, please do not hesitate to call me.  We look forward to being of service.

 

Best regards,

 

	
/s/   Stéphane Besner
    	
 
    	
 
    
	
Stéphane   Besner, B.Sc. M.B.A
    	
 
    	
/s/   B. Nicholas Harvey
    
	
Senior   Client Manager, Sales & Marketing
    	
 
    	
Authorized   Sponsor Representative
    
	
Charles River Laboratoires
    	
 
    	
 
    
	
Preclinical Services Montreal Inc.
    	
 
    	
B.   Nicholas Harvey, Chief Financial Officer
    
	
22022 Transcanadienne
    	
 
    	
Print   (Name and Title)
    
	
Senneville, Québec, Canada H9X 3R3
    	
 
    	
 
    
	
Tel:   (514) 630-2436 Fax: (514) 630-8230
    	
 
    	
January 20,   2012
    
	
e-mail:stephane.besner@crl.com
    	
 
    	
Date
    
	
Web   site: www.criver.com
    	
 
    	
 
    

 

If a PO is required, please submit PO with Letter of Payment Authorization or fax to 514-630-8230.

 

c.c. S. Pryce, D. Tremblay, S Y. Smith, B. Attella, Main File

CRT: 22633, 22708, 22709, 22748, 23477

V:\CLIENTS\Radius\2012\670364.L6.20Jan12 - ALOPA1.doc

 

[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

 

2Exhibit 10.47

 

	
Confidential   Treatment Requested

Under 17 C.F.R.   §§ 200.80(b)(4) and
   240.24b-2
    	

    

 

CHANGE ORDER

 

AMENDED LETTER OF PAYMENT AUTHORIZATION

 

Amendment No. 02

 

May 1, 2012

 

Gary Hattersley, Ph.D.

Vice President, Biology

RADIUS HEALTH, INC.

5th Floor

300 Technology Square

Cambridge, MA 02139

United States

ghattersley@radiuspharm.com

 

	
RE:
    	
STUDY   PN 670364

(Radius   No:10RAD032)
    	
Study   Title: A 2-Year Subcutaneous Injection   Carcinogenicity Study Of BA058 And PTH In The Fisher 344 Rat
    
	
 
    	
 
    	
 
    
	
 
    	
STUDY   START: Week of January 17, 2010
    

 

Dear Gary,

 

This communication is to serve as an Amended Letter of Payment Authorization (ALOPA) for the above referenced study, which will be performed at Charles River Laboratories Preclinical Services as set forth below.  Charles River Laboratories Preclinical Services shall perform these services in accordance with the existing Service Agreement executed between Charles River Laboratories Preclinical Services and RADIUS HEALTH, INC. Once fully executed, this ALOPA shall be incorporated into and made part of the existing Service Agreement.

 

Summary of Changes:

 

· Additional charge for the purchase of 100mg of PTH from Cedarlane

 

The price of this Protocol Amendment is as follows:

 

	
 
    	
Authorized   Price
    	
 
    	
$ [*]
    
	
 
    	
(After   discount)
    	
 
    	
(as   per signed ALOPA dated: January 20, 2012)
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Additional   Charge
    	
 
    	
$ [*]
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Additional   with additional [*]% goodwill discount:
    	
 
    	
$ [*]
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Revised   Price
    	
 
    	
$ 2,494,435 US
    

 

[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

 

1

 

The payment schedules of this study are as follows:

 

· $ [*] First payment at study authorization — (Paid)

· $ [*] Due upon receipt of invoice — (ALOPA1) — (Paid)

· Additional Charge  Due upon receipt of invoice — (ALOPA2)

· 75% Equal monthly installments

· 5% Upon receipt of draft report

· 5% Upon receipt of final report or forty five (45) days after issuance of draft report (whichever comes first)

 

Please sign and return this document via facsimile or email (contact information below).  Should you have any questions or require any additional information, please do not hesitate to call me.  We look forward to being of service.

 

Best regards,

 

	

    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
For:
    	
 
    	
 
    
	
 
    	
 
    	
 
    
	
Stéphane   Besner, B.Sc. M.B.A
    	
 
    	
/s/   B. Nicholas Harvey
    
	
Senior   Client Manager, Sales & Marketing
    	
 
    	
Authorized   Sponsor Representative
    
	
Charles River Laboratoires
    	
 
    	
 
    
	
Preclinical Services Montreal Inc.
    	
 
    	
B.   Nicholas Harvey, Chief Financial Officer
    
	
22022 Transcanadienne
    	
 
    	
Print   (Name and Title)
    
	
Senneville, Québec, Canada H9X 3R3
    	
 
    	
 
    
	
Tel:   (514) 630-2436 Fax: (514) 630-8230
    	
 
    	
May 1,   2012
    
	
e-mail:stephane.besner@crl.com
    	
 
    	
Date
    
	
Web   site: www.criver.com
    	
 
    	
 
    

 

If a PO is required, please submit PO with Letter of Payment Authorization or fax to 514-630-8230.

 

c.c. S. Pryce, D. Tremblay, S Y. Smith, B. Attella, Main File

 

E:\CLIENTS\Radius\2012\670364.L7.01May12 - ALOPA2.doc

 

[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

 

2Exhibit 10.48

 

	
Confidential   Treatment Requested

Under 17 C.F.R.   §§ 200.80(b)(4) and
   240.24b-2
    	

    

 

CHANGE ORDER

 

AMENDED LETTER OF PAYMENT AUTHORIZATION

 

Amendment No. 01

 

September 10, 2012

 

Gary Hattersley, Ph.D.

Vice President, Biology

RADIUS HEALTH, INC.

6th Floor

201 Broadway

Cambridge, MA 02139

United States

ghattersley@radiuspharm.com

 

	
RE:
    	
STUDY   PN 670646
    (Radius No:10RAD029)
    	
Study   Title: A 12-Month Osteoporosis Intervention Study   BA058 by Subcutaneous Injection in the Ovariectomized Sprague Dawley Rats
    
	
 
    	
 
    	
 
    
	
 
    	
As   per Protocol Amendment # 1 dated: April 28, 2011

As   per Protocol Amendment # 2 dated: July 26, 2011

As   per Protocol Amendment # 4 dated: October 20, 2012

As   per Protocol Amendment # 6 dated: July 26, 2012
    
	
 
    	
 
    
	
 
    	
STUDY   START: May 2011
    

 

Dear Gary,

 

This communication is to serve as an Amended Letter of Payment Authorization (ALOPA) for the above referenced study, which will be performed at Charles River Laboratories Preclinical Services as set forth below.  Charles River Laboratories Preclinical Services shall perform these services in accordance with the existing Service Agreement executed between Charles River Laboratories Preclinical Services and RADIUS HEALTH, INC. Once fully executed, this ALOPA shall be incorporated into and made part of the existing Service Agreement.

 

Summary of Changes:

 

·Slide preparation and evaluation

·Statistics added

 

The price of this Protocol Amendment is as follows:

 

	
 
    	
Authorized   Price
    	
 
    	
$ [*]
    
	
 
    	
(after   discount)
    	
 
    	
(as   per signed ALOPA dated: February 1, 2011)
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Additional   Charge
    	
 
    	
$ [*]
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Additional   Charge:
    	
 
    	
 
    
	
 
    	
(with   [*]% + [*]% discounts)
    	
 
    	
$ [*]
    
	
 
    	
 
    	
 
    	
 
    
	
 
    	
Revised   Price
    	
 
    	
$ 1,081,896 US
    

 

 

[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

 

1

 

The payment schedules of this study are as follows:

 

·$ [*] [15%]   Due at animal arrival — (Paid)

·$ [*] [75%]   Equal Monthly Installment — (Invoiced and paid)

·$ [*] Additional Charge   Due upon receipt of invoice — (ALOPA1)

·$ [*] [75%]   Equal Monthly Installment

·$ [*] [5%]  Due upon Submission of Draft Report

·$ [*] [5%] Due upon Submission of Final Report

 

Please sign and return this document via facsimile or email (contact information below).  Should you have any questions or require any additional information, please do not hesitate to call me.  We look forward to being of service.

 

Best regards,

 

	
/s/   Stéphane Besner
    	
 
    	
/s/   Gary Hattersley
    
	
 
    	
 
    	
Authorized   Sponsor Representative
    
	
Stéphane   Besner, B.Sc. M.B.A
    	
 
    	
 
    
	
Senior   Client Manager, Sales & Marketing
    	
 
    	
Gary   Hattersley, SVP Preclinical Development 
    
	
Charles River Laboratoires
    	
 
    	
Print   (Name and Title)
    
	
Preclinical Services Montreal Inc.
    	
 
    	
 
    
	
22022 Transcanadienne
    	
 
    	
September 14,   2012
    
	
Senneville, Québec, Canada H9X 3R3
    	
 
    	
Date
    
	
Tel:   (514) 630-2436 Fax: (514) 630-8230
    	
 
    	
 
    
	
e-mail:stephane.besner@crl.com
    	
 
    	
 
    
	
Web   site: www.criver.com
    	
 
    	
 
    

 

 

If a PO is required, please submit PO with Letter of Payment Authorization or fax to 514-630-8230.

 

c.c. S. Pryce, D. Tremblay, S Y. Smith, E. Lesage

CRT: 24056

E:\CLIENTS\Radius\2012\670646.L7(ALOPA1) 10Sep12.doc

O6UJ9 - A0013JF

 

[*] Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions.

 

2

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