Document:

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                                                                    EXHIBIT 10.1

                              DATE: APRIL 14, 2005

                          OSI PHARMACEUTICALS, INC. (1)

                                       AND

                                DARYL GRANNER (2)

                -----------------------------------------------

                         SHARE PURCHASE DEED RELATING TO

                           SHARES OF PROSIDION LIMITED

                -----------------------------------------------

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                                TABLE OF CONTENTS

<TABLE>
<CAPTION>
<S>                                                            <C>
1.    INTERPRETATION........................................   1

2.    SALE AND PURCHASE OF THE SHARES.......................   2

3.    COMPLETION............................................   3

4.    REPRESENTATIONS.......................................   4

5.    FURTHER ASSURANCE.....................................   4

6.    INVALIDITY............................................   5

7.    NON-ASSIGNMENT........................................   5

8.    NOTICES...............................................   5

9.    THIRD PARTY RIGHTS....................................   5

10.   VARIATION.............................................   6

11.   WAIVER................................................   6

12.   ENTIRE AGREEMENT......................................   6

13.   COUNTERPARTS..........................................   6

14.   GOVERNING LAW.........................................   7
</TABLE>

<PAGE>

THIS DEED is made the 14th day of April, 2005

BETWEEN:

(1)   OSI PHARMACEUTICALS, INC., a company incorporated under the laws of the
      State of Delaware, USA and having its registered office at 58 South
      Service Road, Melville, New York 11747, USA ("THE PARENT Company"); and

(2)   DARYL GRANNER of 3808 Stoney Pointe Lane NE, North Liberty, Iowa 52317 USA
      (THE "MEMBER"),

      (each a "PARTY" and collectively the "PARTIES").

      RECITALS:

(A)   WHEREAS Prosidion Limited (the "COMPANY") was incorporated as a private
      company limited by shares under the laws of England and Wales on 25
      November 2002 (registered number 4600121) and has an authorised share
      capital of (pound)2,000 divided into 14,000,000 Preferred Ordinary Shares
      of (pound)0.0001 each ("PREFERRED ORDINARY SHARES"); 4,000,000 A Ordinary
      Shares of (pound)0.0001 each ("A ORDINARY SHARES"); and 2,000,000 B
      Ordinary Shares of (pound)0.0001 each ("B ORDINARY SHARES").

(B)   WHEREAS 11,000 B Ordinary Shares (the "SHARES") have been issue and
      allotted to the Member.

(C)   WHEREAS the Member is the legal and beneficial owner of the Shares.

(D)   WHEREAS the Parent Company has proposed to acquire all of the Shares from
      the Member for the consideration set out in clause 2.2.

(E)   WHEREAS the Member and the Parent Company have agreed that the Member
      shall sell and the Parent Company shall purchase the Shares on the terms
      set out in this Deed.

IT IS HEREBY AGREED as follows:

1.    INTERPRETATION

1.1   In this Deed, subject to any express contrary indication:

      (a)   words importing the singular shall include the plural and vice
            versa;

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      (b)   any reference to this Deed or any other agreement or document shall
            be construed as a reference to that agreement or document as it may
            have been, or may from time to time be, amended, varied, novated,
            replaced or supplemented;

      (c)   any reference to a statute or enactment shall be construed as a
            reference to such statute as it may have been, or may from time to
            time be, amended or re-enacted and any subordinate legislation made
            or thing done, or may from time to time be done, under the statute
            or enactment provided that, as between the parties, no such
            amendment or modification shall apply for the purposes of this Deed
            to the extent that it would impose any new or extended obligation,
            liability or restriction on, or otherwise adversely affect the
            rights of, any party; and

      (d)   any reference to any English legal term for any action, remedy,
            method of judicial proceeding, legal document, legal status, court,
            official, or any legal concept or thing shall in respect of any
            jurisdiction (other than England) be deemed to include what most
            nearly approximates in that jurisdiction to the English legal term.

1.2   All headings in this Deed are for ease of reference only and shall not
      affect the interpretation of this Deed.

1.3   Capitalized terms used in the Recitals and this Deed shall, unless the
      context otherwise requires, have the meaning set out in the Articles of
      Association of the Company.

2.    SALE AND PURCHASE OF THE SHARES

2.1   At Completion (as hereinafter defined), the Member shall sell the Shares
      as legal and beneficial owner with full title guarantee and the Parent
      Company shall purchase the Shares free of any lien, claim, charge,
      security interest, mortgage, pledge, easement, conditional sale or other
      title retention agreement, defect in title, rights of third parties,
      restrictive covenant or other restrictions of any kind (each an
      "ENCUMBRANCE").

2.2   The consideration for the purchase of the Shares shall be one hundred and
      seventy six thousand US dollars (US$176,000), payable in cash upon
      Completion or as soon as practicable thereafter without set-off or
      counterclaim (the "CONSIDERATION").

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3.    COMPLETION

3.1   Completion shall take place at the offices of Prosidion Limited,
      Watlington Road, Oxford, OX4 6LT on April 14 2005 (the "COMPLETION"). At
      Completion, the Member shall deliver to the Parent Company;

      (a)   duly executed transfers of his Shares in favour of the Parent
            Company together with all share certificates relating to the Shares
            or, in the absence of which, an indemnity letter relating to loss of
            such share certificate; and

      (b)   any other documents which may be required to vest in the Parent
            Company the full legal and beneficial ownership of the Shares and
            enable the Parent Company to procure them to be registered in its
            name or as it may direct.

3.2   At Completion, the Parent Company shall pay the consideration payable in
      respect of the Shares in cash.

3.3   At Completion the Member IRREVOCABLY AND UNCONDITIONALLY APPOINTS the
      Parent Company and each of Colin Goddard of 30 Allenby Drive, Fort
      Solonga, NY 11768, USA, Bob Van Nostrand of 18 Mariners Circle, West
      Islip, NY 11797, USA and Barbara Wood of 200 West 90th Street, Apartment
      12F, New York, NY 10024, USA acting severally (each an "ATTORNEY") to be
      the true and lawful Attorney of the Member with full power to appoint
      substitutes, pending registration of the Parent Company as the legal owner
      of the Shares and in its name or otherwise on its behalf as the Attorney
      sees fit to execute notices, instruments of proxy or other documents which
      may fall to be executed or signed by the Member and exercise and perform
      any of the acts and things to be done and performed by the Member in
      connection with the legal and beneficial ownership of all or any of the
      Shares as if the Attorney were the legal and beneficial owner of the
      Shares and in particular but without limitation the Attorney is appointed
      to:

      (a)   attend any General Meeting (Annual and/or Extraordinary) of the
            Company and to represent the Member and vote on the Member's behalf
            and in its name;

      (b)   exercise in the Member's name and on his behalf, all rights and
            privileges attached to the Shares including but not limited to the
            right to requisition the convening of an Extraordinary General
            Meeting;

                                       3
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      (c)   to receive, in the Member's name and on his behalf, any notice or
            document which the Member is entitled to receive solely by virtue of
            being the registered holder of the Shares including the right to
            receive all benefits and entitlements which attach to the Shares
            from the date of Completion. For the avoidance of doubt this
            paragraph (c) does not cover amounts due to be paid to the Member
            pursuant to his agreement with the Parent Company relating to the
            sale and purchase of the Shares; and

      (d)   execute and do (or procure the execution and giving of) such
            documents, acts and things as in the opinion of the Attorney is
            desirable and in such manner as the Attorney thinks fit as if the
            Attorney were the absolute legal and beneficial owner thereof.

3.4   The power of attorney granted in Clause 3.3 shall expire on the date on
      which the Parent Company is registered as the holder of the Shares in the
      register of members of the Company.

3.5   The Member undertakes to ratify everything which the Attorney shall do or
      purport to do in good faith by virtue of the powers granted by the power
      of attorney granted in Clause 3.3.

4.    REPRESENTATIONS

      The Member represents and warrants to the Parent Company at the date
      hereof that:

      (a)   he is the legal and beneficial owner of the Shares;

      (b)   there is no Encumbrance on, over or affecting any of the Shares;

      (c)   no agreement to create an Encumbrance has been entered into and no
            claim has been made by any person (natural or otherwise) that it is
            entitled to any such Encumbrance;

      (d)   he has full power and authority to enter into and exercise its
            rights and perform its obligations under this Deed and all other
            documents to be executed by him at Completion; and

      (e)   his obligations under this Deed are valid and binding subject to
            applicable law.

5.    FURTHER ASSURANCE

      The Member shall, at the expense of the Parent Company, do or procure to
      be done all such further acts and things and execute or procure the
      execution of all such other documents as the

                                       4
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      Parent Company may from time to time reasonably require for the purpose of
      giving to the Parent Company the full benefit of all the provisions of
      this Deed.

6.    INVALIDITY

      If any provision of this Deed is held to be invalid or unenforceable, then
      such provision shall (so far as it is invalid or unenforceable) be given
      no effect and shall be deemed not to be included in this Deed but without
      invalidating any of the remaining provisions of this Deed. The parties
      shall then use all reasonable endeavours to replace the invalid or
      unenforceable provision by a valid provision the effect of which is as
      close as possible to the intended effect of the invalid or unenforceable
      provision.

7.    NON-ASSIGNMENT

      Neither party shall, without the consent of the other, be entitled to
      assign the benefit or burden of this Deed in whole or in part.

8.    NOTICES

8.1   Any notice to be given under this Deed shall be in writing and shall be
      delivered personally or sent by pre-paid international courier to the
      addressee at the address set out on the face of this Deed or such other
      address as may be notified from time to time. A notice so addressed shall
      be deemed to have been received:

      (a)   if personally delivered, at the time of delivery; and

      (b)   if sent by international courier, two days after the date of
            delivery of the notice to the international courier by the sender.

8.2   For the avoidance of doubt, notice given under this Deed shall not be
      validly served if sent by electronic mail.

9.    THIRD PARTY RIGHTS

      The parties do not intend that any term of this Deed shall be enforceable
      pursuant to the Contracts (Rights of Third Parties) Act 1999 by any person
      who is not a party to this Deed.

                                       5
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10.   VARIATION

      No variation of any of the terms of this Deed (or of any other documents
      referred to herein) shall be valid unless it is in writing and signed by
      or on behalf of each of the parties hereto. The expression "variation"
      shall include any variation, supplement, deletion or replacement however
      effected.

11.   WAIVER

11.1  Any delay by the parties in exercising, or failure to exercise, any right
      or remedy under this Deed shall not constitute a waiver of the right or
      remedy or a waiver of any other rights or remedies and no single or
      partial exercise of any rights or remedy under this Deed or otherwise
      shall prevent any further exercise of the right or remedy or the exercise
      of any other right or remedy.

11.2  The rights and remedies of the parties under this Deed are cumulative and
      not exclusive of any rights or remedies provided by law.

12.   ENTIRE AGREEMENT

      This Deed, together with documents described in or expressed to be entered
      into in connection with this Deed, constitutes the entire Deed between the
      parties with respect to all matters referred to herein and supersede all
      prior written or oral discussions, representations, negotiations and Deeds
      among them regarding such subject matter. Each party confirms that the
      terms of this Deed are fair and reasonable.

13.   COUNTERPARTS

      This Deed may be executed in as many counterparts (including facsimile
      counterparts) as may be required. It shall not be necessary that the
      signatures of, or on behalf of, each party, or that the signatures of all
      persons required to bind any party, appear on each counterpart; but it
      shall be sufficient that the signature of, or on behalf of, each party, or
      that the signatures of the persons required to bind any party, appear on
      one or more of the counterparts. All counterparts shall collectively
      constitute a single Deed. It shall not be necessary in making proof of
      this Deed to produce or account for more than a number of counterparts
      containing the respective signatures of, or on behalf of, all of the
      parties hereto.

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<PAGE>

14.   GOVERNING LAW

14.1  This Deed shall be governed by and construed in accordance with the laws
      of England and Wales.

14.2  In relation to any legal action or proceedings arising out of or in
      connection with this Deed ("PROCEEDINGS"), each of the parties irrevocably
      submits to the non-exclusive jurisdiction of the English courts and waives
      any objection to Proceedings in such courts on the grounds of venue or on
      the grounds that Proceedings have been brought in an inappropriate forum.

                                       7
<PAGE>

IN WITNESS WHEREOF the parties hereto have duly executed this agreement as a
Deed with the intent that it is delivered as such on the day and year first
above written.

EXECUTED AS A DEED                   )
BY                                   )
OSI PHARMACEUTICALS, INC.            )
ACTING BY A DULY AUTHORISED          )
REPRESENTATIVE AND IN ACCORDANCE     )
WITH THE LAWS OF THE JURISDICTION OF )
ITS INCORPORATION AND ARTICLES OF    )
ASSOCIATION/BY - LAWS                )
                                     )             /s/
                                                   _____________________________

EXECUTED AS A DEED BY DARYL GRANNER

SIGNED: /s/
        ---------------------------

IN THE PRESENCE OF:

Witness's Signature: /s/
                     --------------------------

Witness's Name:
                     --------------------------

Witness's Address:
                     --------------------------

                                       8<PAGE>

                                                                    EXHIBIT 10.2

                            OSI PHARMACEUTICALS, INC.
                    AMENDED AND RESTATED STOCK INCENTIVE PLAN
                              STOCK AWARD AGREEMENT

         THIS STOCK AWARD AGREEMENT (the "Agreement") is made this 14th day of
April, 2005 by and between OSI PHARMACEUTICALS, INC., a Delaware corporation
(the "Company") and DARYL GRANNER of 3808 Stoney Pointe Lane NE, North Liberty,
Iowa 52317, USA, (the "Award Recipient").

         WHEREAS, the Company has agreed to acquire the entire issued share
capital of Prosidion Limited which it does not already own, a company
incorporated under the laws of England and Wales ("Prosidion");

         WHEREAS, the Award Recipient currently provides services to Prosidion
as a member of its Scientific Advisory Board ("SAB") and the Company wishes the
Award Recipient to continue to provide such services on and after the closing
date of the Company's acquisition of the entire share capital of Prosidion (the
"Closing Date");s

         WHEREAS, the Award Recipient entered into a share subscription and
vesting agreement with Prosidion as of October 1, 2004 (the "Subscription
Agreement") under which Prosidion agreed to issue shares of Prosidion to the
Award Recipient in accordance with the terms of the Subscription Agreement;

         WHEREAS, Prosidion and the Award Recipient have agreed to terminate the
Subscription Agreement, effective as of the Closing Date, provided that the
Company agrees to issue to the Award Recipient certain shares of common stock of
the Company, par value $.01 per share (the "Common Stock") on terms
substantially similar to the terms of the Subscription Agreement;

         NOW, THEREFORE, the parties hereto mutually agree to the following
terms and conditions of this Agreement:

                  1. STOCK AWARD. Pursuant to the terms of the OSI
Pharmaceutical, Inc. Amended and Restated Stock Incentive Plan (the "Plan"), a
copy of which is attached hereto as Exhibit A, the Company hereby awards to the
Award Recipient the opportunity to earn up to 592 shares of Common Stock based
on an exchange ratio of one (1) share in Prosidion to 0.29685 shares of Common
Stock in accordance with the terms and conditions of this Agreement (the "Stock
Award").

No certificates representing fractional shares of the Parent Company Stock shall
be issued, and such fractional share interests will not entitle the Member to
vote or to any other rights of a stockholder of the Parent Company. With respect
to any fractional share interest to which the Member is entitled, the Member
shall be paid an amount in cash equal to the product obtained by multiplying (i)
such fractional share interest to which the Member would otherwise be entitled
by (ii) $53.90.

                  2. CONDITIONED ON DEED OF TERMINATION AND RELEASE. The
issuance of any shares of Common Stock under this Stock Award is conditioned on
the Award Recipient's agreement to, and execution of, the Deed of Termination
and Release in the form attached hereto as Exhibit B, effective as of the
Closing Date.

                  3. ISSUANCE OF SHARES. As of each Vesting Date indicated in
the following schedule, the Company shall issue to the Award Recipient the
number of shares of Common Stock indicated in such schedule; provided, however,
that such shares of Commons Stock shall not be issued if

<PAGE>

the Award Recipient's service as a member of the Board has terminated for any
reason prior to such Vesting Date:

<TABLE>
<CAPTION>
NUMBER OF SHARES OF COMMON STOCK            VESTING DATE
--------------------------------            ------------
<S>                                         <C>
              296                           October 1, 2005
              296                           October 1, 2006
</TABLE>

The provision relating to fractional shares in Section 1 above shall apply.

         4. TERMINATION AND FORFEITURE. This Agreement shall terminate, and the
Award Recipient's interest in shares of Common Stock not yet issued hereunder
shall be forfeited, as of the date the Award Recipient's service as a member of
the SAB of Prosidion terminates for any reason.

         5. WITHHOLDING OF APPLICABLE TAXES. It shall be a condition precedent
to the Company's obligation to issue shares of Common Stock pursuant to this
Stock Award that the Award Recipient pay, or make provision satisfactory to the
Company for the payment of, any taxes the Company is obligated to collect with
respect to the issuance of Common Stock under this Stock Award, including but
not limited to, any applicable, federal, state, or local withholding or
employment taxes.

         6. SECURITIES LAWS. The Company shall not be obligated to issue any
shares of Common Stock under this Stock Award in any manner in contravention of
the Securities Act of 1933, as amended, any other federal or state securities
law or the rules of any exchange or market system upon which the Common Stock is
traded. The Board of Directors of the Company or the Committee (as designated
under the Plan) may, at any time, require, as a condition to the issuance of
shares of Common Stock hereunder, the representation or agreement of the Award
Recipient to the effect that the shares issuable hereunder are acquired by the
Award Recipient for investment purposes and not with a view to the resale or
distribution thereof, and may require such other representations and documents
as may be required to comply with applicable securities laws or the rules of any
applicable exchange or market system.

         7. SUBJECT TO TERMS OF PLAN. This Stock Award is awarded pursuant to,
and is subject to the terms and provisions of, the Plan. All terms used herein
which are defined in the Plan and not otherwise defined herein shall have the
same meanings as in the Plan. To the extent that the provisions hereof conflict
with those of the Plan, the provisions of the Plan shall control. All decisions
or interpretations made by the Committee regarding any issue or question arising
under this Stock Award or the Plan shall be final, binding and conclusive on the
Company and the Award Recipient.

         8. RIGHTS AS STOCKHOLDER. The Award Recipient shall have none of the
rights of a stockholder with respect to shares of Common Stock that may be
issued under this Agreement unless and until such shares shall be issued in
accordance with the terms hereof.

         9. CONTINUED SERVICE. Nothing contained herein or in the Plan shall
confer to the Award Recipient any right to continue in the service of the
Company, Prosidion or any affiliate of either, or interfere in any way with the
right of the Company, Prosidion or any affiliate of either, to terminate the
services, responsibilities or duties of the Award Recipient at any time for any
reason whatsoever.

         10. BINDING EFFECT. This agreement shall be binding upon and inure to
the benefit of the parties hereto, including the successors and assigns of the
Company and the heirs and personal representatives of the Award Recipient.

                                      -2-
<PAGE>

         IN WITNESS WHEREOF, the parties hereto execute this Agreement as of the
day and year first above written.

                                            OSI PHARMACEUTICALS, INC.

                                            /s/ Robert L. Van Nostrand
                                            --------------------------
                                            Name: Robert L. Van Nostrand
                                            Title: Vice President and
                                                   Chief Financial Officer

                                            /s/ Daryl Granner
                                            -------------------
                                            Name: DARYL GRANNER

                                      -3-

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