Document:

EX-4.6

 Exhibit 4.6 
  

 
 ESSA PHARMA INC. 

Special Warrant Indenture 
  

 
 January 16, 2015 

 TABLE OF CONTENTS 

 

									
	1.		INTERPRETATION		 	1	  
			1.1		 Definitions
		 	1	  
			1.2		 Headings
		 	5	  
			1.3		 Gender
		 	5	  
			1.4		 Weekends and Holidays
		 	5	  
			1.5		 Meaning of “Outstanding”
		 	5	  
			1.6		 Time
		 	6	  
			1.7		 Applicable Law
		 	6	  
			1.8		 Severability
		 	6	  
			1.9		 Currency
		 	6	  
			1.10		 Conflicts
		 	6	  
			1.11		 Schedules
		 	6	  
			
	2.		ISSUE AND PURCHASE OF SPECIAL WARRANTS		 	6	  
			2.1		 Creation, Form and Terms of Special Warrants
		 	6	  
			2.2		 Form of Warrants, Certificated Warrants
		 	6	  
			2.3		 Book Entry Only Warrants
		 	7	  
			2.4		 Special Warrant Certificate
		 	8	  
			2.5		 Transferability and Ownership of Special Warrants
		 	9	  
			2.6		 Special Warrantholders Not Shareholders
		 	12	  
			2.7		 Signing of Special Warrants
		 	12	  
			2.8		 Countersigning
		 	13	  
			2.9		 Loss, Mutilation, Destruction or Theft of Special Warrants
		 	13	  
			2.10		 Exchange of Special Warrants
		 	13	  
			2.11		 Ranking
		 	14	  
			2.12		 Purchase of Special Warrants for Cancellation
		 	14	  
			2.13		 Cancellation of Surrendered Special Warrants
		 	14	  
			
	3.		REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE COMPANY		 	14	  
			3.1		 To Issue Special Warrants and Reserve Common Shares
		 	14	  
			3.2		 To Execute Further Assurances
		 	14	  
			3.3		 To Carry On Business
		 	14	  
			3.4		 No Breach of Constating Documents
		 	15	  
			3.5		 Notices to Special Warrant Agent
		 	15	  
			3.6		 Securities Qualification Requirements
		 	15	  
			3.7		 Satisfy Covenants
		 	15	  
			3.8		 Performance of Covenants by Special Warrant Agent
		 	15	  
			3.9		 Special Warrant Agent’s Remuneration and Expenses
		 	15	  
			3.10		 Trust for Special Warrantholder’s Benefit
		 	16	  
			3.11		 Notice to Special Warrantholders of Certain Events
		 	16	  
			3.12		 Closure of Share Transfer Books
		 	16	  
			3.13		 Payment of Commissions
		 	17	  
			3.14		 Registration under the 1934 Act
		 	17	  
			
	4.		ADJUSTMENT OF NUMBER OF WARRANT SHARES		 	17	  
			4.1		 Adjustment of Number of Warrant Shares
		 	17	  
			4.2		 Adjustment if U.S. Listing Date does not Occur on or Prior to the Deadline Date
		 	20	  
			4.3		 Proceedings Prior to any Action Requiring Adjustment
		 	20	  
			4.4		 Certificate of Adjustment
		 	20	  
			4.5		 No Action After Notice
		 	21	  
			4.6		 Protection of Special Warrant Agent
		 	21	  
			4.7		 Notice of Special Matters
		 	21	  
			
	5.		EXERCISE, RETRACTION AND CANCELLATION OF SPECIAL WARRANTS		 	21	  
			5.1		 Notice of Deemed Exercise to Special Warrantholders
		 	21	  
			5.2		 Voluntary Exercise of Special Warrants
		 	21	  
			5.3		 Deemed Exercise of Special Warrants
		 	22	  

  
 i 

									
			 5.4
		Effect of Exercise of Special Warrants		 	22	  
			 5.5
		Partial Exercise		 	23	  
			 5.6
		Special Warrants Void After Exercise Time		 	23	  
			 5.7
		Fractions of Warrant Shares		 	23	  
			 5.8
		Accounting and Recording		 	23	  
			 5.9
		Legending of Special Warrant Certificates and Underlying Securities		 	23	  
			 5.10
		Issuance of Warrant Shares		 	24	  
			 5.11
		Securities Restrictions		 	25	  
			 5.12
		Mandatory Purchase for Cancellation and Voluntary Retraction		 	25	  
			
	 6.
		 MEETINGS OF SPECIAL WARRANTHOLDERS
		 	27	  
			 6.1
		Definitions		 	27	  
			 6.2
		Convening Meetings		 	27	  
			 6.3
		Place of Meeting		 	28	  
			 6.4
		Notice		 	28	  
			 6.5
		Persons Entitled to Attend		 	28	  
			 6.6
		Quorum		 	28	  
			 6.7
		Chairman		 	28	  
			 6.8
		Power to Adjourn		 	28	  
			 6.9
		Adjourned Meeting		 	29	  
			 6.10
		Show of Hands		 	29	  
			 6.11
		Poll		 	29	  
			 6.12
		Regulations		 	29	  
			 6.13
		Powers of Special Warrantholders		 	30	  
			 6.14
		Powers Cumulative		 	31	  
			 6.15
		Minutes of Meetings		 	31	  
			 6.16
		Written Resolutions		 	31	  
			 6.17
		Binding Effect		 	31	  
			 6.18
		Holdings by the Company or Subsidiaries of the Company Disregarded		 	31	  
			
	 7.
		 SUPPLEMENTAL INDENTURES, MERGER, SUCCESSORS
		 	31	  
			 7.1
		Provision for Supplemental Indentures for Certain Purposes		 	31	  
			 7.2
		Company May Consolidate, etc. on Certain Terms		 	32	  
			 7.3
		Successor Body Corporate Substituted		 	32	  
			
	 8.
		 CONCERNING THE SPECIAL WARRANT AGENT
		 	33	  
			 8.1
		Duties of Special Warrant Agent		 	33	  
			 8.2
		Action by Special Warrant Agent		 	33	  
			 8.3
		Certificate of the Company		 	33	  
			 8.4
		Special Warrant Agent May Employ Experts		 	33	  
			 8.5
		Resignation and Replacement of Special Warrant Agent		 	33	  
			 8.6
		Indenture Legislation		 	34	  
			 8.7
		Notice		 	34	  
			 8.8
		Use of Proceeds		 	34	  
			 8.9
		No Inquiries		 	34	  
			 8.10
		Actions by Special Warrant Agent to Protect Interest		 	34	  
			 8.11
		Special Warrant Agent Not Required to Give Security		 	34	  
			 8.12
		No Conflict of Interest		 	34	  
			 8.13
		Special Warrant Agent Not Ordinarily Bound		 	35	  
			 8.14
		Special Warrant Agent May Deal in Instruments		 	35	  
			 8.15
		Recitals or Statements of Fact Made by Company		 	35	  
			 8.16
		Special Warrant Agent’s Discretion Absolute		 	35	  
			 8.17
		No Representations as to Validity		 	35	  
			 8.18
		Acceptance of Trusts		 	36	  
			 8.19
		Special Warrant Agent’s Authority to Carry on Business		 	36	  
			 8.20
		Indemnification of Special Warrant Agent		 	36	  
			 8.21
		Performance of Covenants by Special Warrant Agent		 	36	  
			 8.22
		Third Party Interests		 	36	  
			 8.23
		Not Bound to Act		 	37	  

  
 ii 

									
			
	 9.
		 NOTICES
		 	37	  
			 9.1
		Notice to Company, Special Warrant Agent and Agent		 	37	  
			 9.2
		Notice to Special Warrantholders		 	38	  
			
	 10.
		 POWER OF BOARD OF DIRECTORS
		 	38	  
			 10.1
		Board of Directors		 	38	  
			
	 11.
		 MISCELLANEOUS PROVISIONS
		 	38	  
			 11.1
		Further Assurances		 	38	  
			 11.2
		Unenforceable Terms		 	38	  
			 11.3
		No Waiver		 	38	  
			 11.4
		Waiver by Special Warrantholders and Special Warrant Agent		 	39	  
			 11.5
		Suits by Special Warrantholders		 	39	  
			 11.6
		SEC Reporting Status		 	39	  
			 11.7
		Force Majeure		 	40	  
			 11.8
		Privacy Matters		 	40	  
			 11.9
		Enurement		 	40	  
			 11.10
		Formal Date and Effective Date		 	41	  

  
 iii 

 SPECIAL WARRANT INDENTURE 

THIS SPECIAL WARRANT INDENTURE made as of January 16, 2015. 

BETWEEN: 

ESSA PHARMA INC., a corporation incorporated under the laws of British Columbia and having an office in the City of
Vancouver, British Columbia 
 (the “Company”) 

OF THE FIRST PART 
 AND: 

COMPUTERSHARE TRUST COMPANY OF CANADA, a trust company existing under the laws of Canada and having an office in the
City of Vancouver, British Columbia 
 (the “Special Warrant Agent”) 

OF THE SECOND PART 

WHEREAS the Company is proposing to issue up to 4,363,636 Special Warrants in the manner herein set forth; 

AND WHEREAS the Company is authorized to create and issue the Special Warrants; 

AND WHEREAS the Company represents to the Special Warrant Agent that all necessary resolutions of the directors of the
Company have been or will be duly enacted, passed or confirmed and all other proceedings taken and conditions complied with to authorize the execution and delivery of this Agreement and the execution and issue of the Special Warrants and to make the
same legal, valid and binding on the Company in accordance with the laws relating to the Company; 
 AND WHEREAS the
foregoing recitals are made as representations and statements of fact by the Company and not by the Special Warrant Agent; 

AND WHEREAS the Special Warrant Agent has been appointed by the Company and has agreed to act as trustee on behalf of
the Special Warrantholders on the terms and conditions set forth herein. 
 NOW THEREFORE THIS INDENTURE WITNESSETH
THAT, in consideration of the premises and in further consideration of the mutual covenants herein set forth, the parties hereto agree as follows: 
  

	1.	 INTERPRETATION 

  

	1.1	 Definitions 

In this Indenture, unless there is something in the subject matter or context inconsistent therewith, the following words have
the respective meaning indicated below: 
  

	 	(a)	 “Agency Agreement” means the agency agreement dated January 16, 2015, between the Company and the Agent in relation to the
Private Placement; 

  

	 	(b)	 “Agent” means Bloom Burton & Co. Limited; 

	 	(c)	 “Applicable Legislation” means the provisions, if any, for the time being, of any statute of Canada or a province thereof, and of
the regulations under such statute, relating to warrant indentures and to the rights, duties and obligations of warrant agents under warrant indentures, and of corporations issuing their securities under warrant indentures, to the extent that any
such provisions are in force and applicable to this Indenture; 

  

	 	(d)	 “Authenticated” means (a) with respect to the issuance of a Special Warrant Certificate, one which has been duly signed by
the Company and authenticated by manual signature of an authorized officer of the Special Warrant Agent, (b) with respect to the issuance of an Uncertificated Warrant, one in respect of which the Special Warrant Agent has completed all Internal
Procedures such that the particulars of such Uncertificated Warrant are entered in the register of holders of Warrants, “Authenticate”, “Authenticating” and “Authentication” have the appropriate
correlative meanings; 

  

	 	(e)	 “Book Entry Only Participants” means institutions that participate directly or indirectly in the Depository’s book entry
registration system for the Special Warrants; 

  

	 	(f)	 “Book Entry Only Warrants” means Special Warrants that are to be held only by or on behalf of the Depository;

  

	 	(g)	 “Business Day” means a day which is not a Saturday, a Sunday or a statutory holiday in the City of Toronto, Ontario or the City of
Vancouver, British Columbia; 

  

	 	(h)	 “CDS Global Warrants” means Special Warrants representing all or a portion of the aggregate number of Special Warrants issued in
the name of the Depository represented by an Uncertificated Warrant, or if requested by the Depository or the Company, by a Special Warrant Certificate; 

  

	 	(i)	 “Change of Control” means any of the following events: 

 

	 	(i)	 any person or group of persons “acting in concert” (as interpreted in accordance with applicable Canadian securities laws) shall have
acquired legal or beneficial ownership of, or the power to exercise control or direction over, Common Shares representing more than 66 and 2/3% of the total number of Common Shares then outstanding; 

 

	 	(ii)	 there is consummated any amalgamation, merger, arrangement, consolidation or other reorganization or acquisition involving the Company or any of
its subsidiaries and another corporation or other entity, as a result of which the holders of Common Shares prior to the completion of the transaction hold less than 66 and 2/3% of the issued and outstanding shares of the successor corporation after
completion of the transaction; 

  

	 	(iii)	 any person or group of persons acting in concert shall succeed in having a sufficient number of its nominees elected as directors of the Company
such that such nominees, when added, after such election, to any existing directors who are nominees of or affiliates or related persons of such person or group of persons, will constitute a majority of the directors of the Company;

  

	 	(iv)	 50% or more of the directors who are directors as at the Closing Date either resign or are removed from the Company’s board of directors;

  

	 	(v)	 a sale of all or a material portion of the assets of the Company; or 

 

	 	(vi)	 a strategic alliance, partnership or joint venture with a third party with upfront cash consideration payable by the third party to the Company in
excess of $50,000,000; 

  

	 	(j)	 “Closing” means the completion of the issuance and sale of Special Warrants by the Company to purchasers in accordance with the
Agency Agreement; 

  
 2 

	 	(k)	 “Closing Date” means January 16, 2015; 

 

	 	(l)	 “Commissions” means the securities commissions of the Designated Provinces; 

 

	 	(m)	 “Common Share” means a fully paid and non-assessable common share in the capital of the Company as such capital is presently
constituted; 

  

	 	(n)	 “Company” means ESSA Pharma Inc., a corporation incorporated under the laws of British Columbia and having an office in the City
of Vancouver, British Columbia; 

  

	 	(o)	 “Company’s auditors” means the firm of accountants appointed by the shareholders of the Company and serving as the auditors
of the Company at the relevant time; 

  

	 	(p)	 “Current Market Price” of a Common Share at any date means the price per share equal to the weighted average price at which the
Common Shares have traded during any 10 consecutive Trading Days selected by the Company, commencing not more than 20 Trading Days and ending not less than five Trading Days before such date, on the TSX Venture Exchange, or, if the Common Shares are
not listed thereon, on any stock exchange on which such shares are listed as may be selected for such purpose by the directors or, if such shares are not listed on any stock exchange, then on such over-the-counter market in Canada as may be selected
for such purpose by the directors, provided further that if the Common Shares are not then listed on any Canadian stock exchange or traded in the over-the counter market, then the Current Market Price shall be determined by such firm of
independent chartered accountants as may be selected by the directors of the Company; 

  

	 	(q)	 “Deadline Date” means October 16, 2015; 

 

	 	(r)	 “Deemed Exercise Date” means the first Business Day after the earlier of: 

 

	 	(i)	 the Deadline Date; and 

  

	 	(ii)	 the U.S. Listing Date; 

  

	 	(s)	 “Deemed Exercise Time” means 4:00 p.m. (Vancouver time) on the Deemed Exercise Date; 

 

	 	(t)	 “Depository” means CDS Clearing and Depository Services Inc. or such other Person as is designated in writing by the Company to
act as depository in respect of the Special Warrants; 

  

	 	(u)	 “Designated Provinces” means each of the Provinces of British Columbia and Ontario; 

 

	 	(v)	 “director” means a director of the Company for the time being and, unless otherwise specified herein, a reference to an action by
the directors means an action by the directors of the Company as a board or, whenever duly empowered, action by a committee of such board; 

  

	 	(w)	 “Dividends paid in the Ordinary Course” means such dividends payable in cash (or in securities, property or assets of equivalent
value) declared payable on a Common Share in any fiscal year of the Company to the extent that such dividends in the aggregate do not exceed in amount or value the greater of: 

 

	 	(i)	 100% of the aggregate amount or value of the dividends declared payable by the Company on the Common Shares in the period of 12 consecutive months
ended immediately prior to the first calendar day of such fiscal year; and 

  

	 	(ii)	 50% of the consolidated net earnings of the Company, before extraordinary items and after dividends paid on any and all Common Shares of the
Company (if any) for the period of 12 consecutive months ended immediately prior to the first calendar day of such fiscal year (such consolidated net earnings to be as shown in the audited consolidated

  
 3 

	 	 
financial statements of the Company for such 12 month period or, if there are no audited financial statements in respect of such period, computed in accordance with generally accepted accounting
principles consistent with those applied in the preparation of the most recent audited consolidated financial statements of the Company); 

and for such purposes the amount of any dividends paid in other than cash or shares of the Company shall be the fair market
value of such dividends as determined by the directors; 
  

	 	(x)	 “Indenture”, “herein”, “hereto”, “hereunder”, “hereof”,
“hereby” and similar expressions mean or refer to this Indenture and not to any particular Article, Section, paragraph, clause, subdivision or portion hereof and include any indenture, deed or instrument supplemental or ancillary
hereto; and the expressions “Article”, “Section” and “paragraph” followed by a number mean and refer to the specified Article, Section or paragraph of this Indenture; 

 

	 	(y)	 “Internal Procedures” means in respect of the making of any one or more entries to, changes in or deletions of any one or more
entries in the register at any time (including without limitation, original issuance or registration of transfer of ownership) the minimum number of the Special Warrant Agent’s internal procedures customary at such time for the entry, change or
deletion made to be complete under the operating procedures followed at the time by the Special Warrant Agent, it being understood that neither preparation and issuance shall constitute part of such procedures for any purpose of this definition;

  

	 	(z)	 “NASDAQ” means one of the Nasdaq Global Select Market, the Nasdaq Global Market or the Nasdaq Capital Market market tiers of the
NASDAQ Stock Market LLC (a U.S. national securities exchange); 

  

	 	(aa)	 “NYSE” means the NYSE MKT LLC (a U.S. national securities exchange); 

 

	 	(bb)	 “Private Placement” means the private placement of up to 4,363,636 Special Warrants pursuant to the Agency Agreement;

  

	 	(cc)	 “Purchase Price” means US$2.75 per Special Warrant; 

 

	 	(dd)	 “Retraction Period” means within 30 calendar days after a Change of Control; 

 

	 	(ee)	 “SEC” means the United States Securities and Exchange Commission; 

 

	 	(ff)	 “Special Warrant” means a special warrant of the Company created by the Company and issued hereunder for the Purchase Price and
entitling the holder thereof to acquire one Common Share upon exercise or deemed exercise thereof, subject to adjustment in accordance with this Indenture, without payment of additional consideration, subject to adjustment as set out herein;

  

	 	(gg)	 “Special Warrant Agent” means Computershare Trust Company of Canada, a trust company existing under the laws of Canada, in its
capacity as special warrant agent hereunder, having an office at 3rd Floor, 510 Burrard Street, Vancouver, British Columbia, Canada, V6C 3B9 or such other address as it shall inform the Company
and the Special Warrantholders from time to time; 

  

	 	(hh)	 “Special Warrant Certificate” means a certificate evidencing one or more Special Warrants issuable hereunder, substantially in the
form attached hereto as Schedule “A”; 

  

	 	(ii)	 “Special Warrantholder” means the registered holder from time to time of an outstanding Special Warrant; 

 

	 	(jj)	 “Subsidiary of the Company” means a corporation of which voting securities carrying a majority of the votes attached to all
outstanding voting securities of the Company are owned, directly or indirectly, by the Company or by one or more subsidiaries of the Company, or by the Company and one or more subsidiaries of the Company, and, as used in this definition, voting
securities means securities, other than debt securities, carrying a voting right to elect directors either under all circumstances or under some circumstances that may have occurred and are continuing; 

  
 4 

	 	(kk)	 “Trading Day” means any day on which the facilities of the TSX Venture Exchange, or, if the Common Shares are not listed thereon,
the facilities of any stock exchange on which the Common Shares are listed, are open for trading; 

  

	 	(ll)	 “Uncertificated Warrant” means any Special Warrant which is not represented by a Special Warrant Certificate;

  

	 	(mm)	 “U.S. Listing Date” means the date on which the Common Shares first begin to trade on either NASDAQ or the NYSE;

  

	 	(nn)	 “United States” means the United States of America, its territories and possessions, any State of the United States and the
District of Columbia; 

  

	 	(oo)	 “Warrant Shares” means the Common Shares issuable upon the exercise or deemed exercise of the Special Warrants;

  

	 	(pp)	 “Voluntary Retraction Price” means 110% of the Purchase Price; 

 

	 	(qq)	 “1933 Act” means the United States Securities Act of 1933, as the same has been, and hereafter from time to time, may be
amended; and 

  

	 	(rr)	 “1934 Act” means the United States Securities Exchange Act of 1934, as the same has been, and hereafter from time to time,
may be amended. 

  

	1.2	 Headings 

The division of this Indenture into Articles, Sections or other subdivisions, the provision of a Table of Contents and the
insertion of headings are for convenience of reference only and shall not affect the construction or interpretation of this Indenture or the Special Warrants. 
  

	1.3	 Gender 

Words importing the singular number also include the plural and vice versa and words importing the masculine gender include the
feminine gender. 
  

	1.4	 Weekends and Holidays 

If the date for the taking of any action under this Indenture expires on a calendar day which is not a Business Day, such
action may be taken on the next succeeding Business Day with the same force and effect as if taken within the period for the taking of such action. 
  

	1.5	 Meaning of “Outstanding” 

Every Special Warrant represented by a Special Warrant Certificate countersigned by the Special Warrant Agent and delivered to
the holder thereof is deemed to be outstanding until it is cancelled or delivered to the Special Warrant Agent for cancellation or until the Deemed Exercise Time. Where a new Special Warrant Certificate has been issued pursuant to Section 2.9
to replace one which has been mutilated, lost, stolen or destroyed, the Special Warrants represented by only one of such Special Warrant Certificates are counted for the purpose of determining the aggregate number of Special Warrants outstanding. A
Special Warrant Certificate representing a number of Special Warrants which has been partially exercised will be deemed to be outstanding only to the extent of the unexercised portion of the Special Warrants. 

  
 5 

	1.6	 Time 

Time is of the essence hereof and in respect of each Special Warrant Certificate. 

 

	1.7	 Applicable Law 

This Indenture and each Special Warrant Certificate are subject to and construed in accordance with the laws of the Province of
British Columbia and the laws of Canada applicable therein. Each of the parties hereto, which shall include the Special Warrantholders, irrevocably attorns to the exclusive jurisdiction of the courts of the Province of British Columbia with respect
to all matters arising out of this Indenture and the transactions contemplated herein. 
  

	1.8	 Severability 

Wherever possible, each provision hereof shall be interpreted in such manner as to be effective and valid under applicable law.
In the event that any provision hereof shall be determined to be invalid, illegal or unenforceable in any respect under applicable law the validity, legality and enforceability of the remainder of such provision and any other provision hereof shall
not be affected or impaired thereby. 
  

	1.9	 Currency 

All references to currency herein are to Canadian dollars unless otherwise indicated. 

 

	1.10	 Conflicts 

In the event of any conflict or inconsistency between the provisions of this Indenture and the Special Warrant Certificates,
the provisions of this Indenture will govern. 
  

	1.11	 Schedules 

The attached Schedule “A” is incorporated into and forms part of this Indenture. 

 

	2.	 ISSUE AND PURCHASE OF SPECIAL WARRANTS 

  

	2.1	 Creation, Form and Terms of Special Warrants 

 

	 	(a)	 The Company hereby creates and authorizes for issuance up to 4,363,636 Special Warrants at the Purchase Price, each such Special Warrant entitling
a Special Warrantholder to acquire one Warrant Share (subject to adjustment in accordance with Article 4) at no additional cost. 

  

	 	(b)	 Subject to the provisions hereof, the Special Warrants issued under this Indenture are limited in the aggregate to 4,363,636 Special Warrants;
provided that the number of Warrant Shares is subject to increase or decrease so as to give effect to the adjustments required by Article 4. 

  

	2.2	 Form of Warrants, Certificated Warrants 

The Special Warrants may be issued in both certificated and uncertificated form. Each Special Warrant originally issued to a
person within the United States will be evidenced in certificated form only and bear the applicable legends as set forth herein. All Special Warrants issued in certificated form shall be evidenced by a Special Warrant Certificate (including all
replacements issued in accordance with this Indenture), substantially in the form set out in Schedule “A” hereto, which shall be dated as of the Closing Date, shall bear such distinguishing letters and numbers as the Company may, with the
approval of the Special Warrant Agent, prescribe, and shall be issuable in any denomination excluding fractions. All Special Warrants issued to the Depository may be in either a certificated or uncertificated form, such uncertificated form being
evidenced by a book position on the register of Special Warrantholders to be maintained by the Special Warrant Agent. 

  
 6 

	2.3	 Book Entry Only Warrants 

  

	 	(a)	 Reregistration of beneficial interests in and transfers of Special Warrants held by the Depository, if any, shall be made only through the book
entry registration system and no Special Warrant Certificates shall be issued in respect of such Special Warrants except where physical certificates evidencing ownership in such securities are required or as set out herein or as may be requested by
the Depository, as determined by the Company, from time to time. Except as provided herein, owners of beneficial interests in any CDS Global Warrants shall not be entitled to have Special Warrants registered in their names and shall not receive or
be entitled to receive Special Warrants in definitive form or to have their names appear in the register. Notwithstanding any terms set out herein, Special Warrants having any legend set forth in Section 2.4(f) herein and held in the name of
the Depository may only be held in the form of Uncertificated Warrants with the prior consent of the Special Warrant Agent and in accordance with the Internal Procedures of the Special Warrant Agent. 

 

	 	(b)	 Notwithstanding any other provision in this Indenture, no CDS Global Warrants may be exchanged for Special Warrants registered, and no transfer of
any CDS Global Warrants may be registered, in the name of any Person other than the Depository for such CDS Global Warrants or a nominee thereof unless: 

  

	 	(i)	 the Depository notifies the Company that it is unwilling or unable to continue to act as depository in connection with the Book Entry Only Warrants
and the Company is unable to locate a qualified successor; 

  

	 	(ii)	 the Company determines that the Depository is no longer willing, able or qualified to discharge properly its responsibilities as holder of the CDS
Global Warrants and the Company is unable to locate a qualified successor; 

  

	 	(iii)	 the Depository ceases to be a clearing agency or otherwise ceases to be eligible to be a depository and the Company is unable to locate a qualified
successor; 

  

	 	(iv)	 the Company determines that the Special Warrants shall no longer be held as Book Entry Only Warrants through the Depository; 

 

	 	(v)	 such right is required by applicable law, as determined by the Company and the Company’s counsel; or 

 

	 	(vi)	 such registration is effected in accordance with the internal procedures of the Depository and the Special Warrant Agent, 

following which, Special Warrants for those holders requesting the same shall be registered and issued to the beneficial
owners of such Special Warrants or their nominees as directed by the holder. The Company shall provide an Officer’s Certificate giving notice to the Special Warrant Agent of the occurrence of any event outlined in this Section. 

 

	 	(c)	 Every Special Warrant that is Authenticated upon registration or transfer of a CDS Global Warrant, or in exchange for or in lieu of a CDS Global
Warrant or any portion thereof, shall be Authenticated in the form of, and shall be, a CDS Global Warrant, unless such Warrant is registered in the name of a person other than the Depository for such CDS Global Warrant or a nominee thereof.

  

	 	(d)	 Notwithstanding anything to the contrary in this Indenture, the CDS Global Warrant, if issued, will be issued as an Uncertificated Warrant, unless
otherwise requested in writing by the Depository or the Company. 

  

	 	(e)	 The rights of beneficial owners of Special Warrants who hold securities entitlements in respect of the Special Warrants through the book entry
registration system shall be limited to those 

  
 7 

	 	 
established by applicable law and agreements between the Depository and the Book Entry Only Participants and between such Book Entry Only Participants and the beneficial owners of Special
Warrants who hold securities entitlements in respect of the Special Warrants through the book entry registration system, and such rights must be exercised through a Book Entry Only Participant in accordance with the rules and procedures of the
Depository. 

  

	 	(f)	 Notwithstanding anything herein to the contrary, neither the Company nor the Special Warrant Agent nor any agent thereof shall have any
responsibility or liability for: 

  

	 	(i)	 the electronic records maintained by the Depository relating to any ownership interests or any other interests in the Special Warrants or the
depository system maintained by the Depository, or payments made on account of any ownership interest or any other interest of any person in any Special Warrant represented by an electronic position in the book entry registration system (other than
the Depository or its nominee); 

  

	 	(ii)	 maintaining, supervising or reviewing any records of the Depository or any Book Entry Only Participant relating to any such interest; or

  

	 	(iii)	 any advice or representation made or given by the Depository or those contained herein that relate to the rules and regulations of the Depository
or any action to be taken by the Depository on its own direction or at the direction of any Book Entry Only Participant. 

  

	 	(g)	 The Company may terminate the application of this Section in its sole discretion in which case all Special Warrants shall be evidenced by Special
Warrant Certificates registered in the name of a Person other than the Depository. 

  

	2.4	 Special Warrant Certificate 

  

	 	(a)	 For Special Warrants issued in certificated form, the form of certificate representing Special Warrants shall be substantially as set out in
Schedule “A” hereto or such other form as is authorized from time to time by the Special Warrant Agent. Each Special Warrant Certificate shall be Authenticated manually on behalf of the Special Warrant Agent. Each Special Warrant
Certificate shall be signed by any one duly authorized signatory of the Company; whose signature shall appear on the Special Warrant Certificate and may be printed, lithographed or otherwise mechanically reproduced thereon and, in such event,
certificates so signed are as valid and binding upon the Company as if it had been signed manually. Any Special Warrant Certificate which has one signature as hereinbefore provided shall be valid notwithstanding that one or more of the persons whose
signature is printed, lithographed or mechanically reproduced no longer holds office at the date of issuance of such certificate. The Special Warrant Certificates may be engraved, printed or lithographed, or partly in one form and partly in another,
as the Special Warrant Agent may determine. 

  

	 	(b)	 The Special Warrant Agent shall Authenticate Uncertificated Warrants (whether upon original issuance, exchange, registration of transfer, partial
payment, or otherwise) by completing its Internal Procedures and the Company shall, and hereby acknowledges that it shall, thereupon be deemed to have duly and validly issued such Uncertificated Warrants under this Indenture. Such Authentication
shall be conclusive evidence that such Uncertificated Warrant has been duly issued hereunder and that the holder or holders are entitled to the benefits of this Indenture. The register shall be final and conclusive evidence as to all matters
relating to Uncertificated Warrants with respect to which this Indenture requires the Special Warrant Agent to maintain records or accounts. In case of differences between the register at any time and any other time the register at the later time
shall be controlling, absent manifest error and such Uncertificated Warrants are binding on the Company. 

  

	 	(c)	 No Special Warrant shall be considered issued and shall be valid or obligatory or shall entitle the holder thereof to the benefits of this
Indenture, until it has been Authenticated by the Special Warrant Agent. Authentication by the Special Warrant Agent, including by way of entry on the 

  
 8 

	 	 
register or otherwise, shall not be construed as a representation or warranty by the Special Warrant Agent as to the validity of this Indenture or of such Special Warrant Certificates or
Uncertificated Warrants (except the due Authentication thereof) or as to the performance by the Company of its obligations under this Indenture and the Special Warrant Agent shall in no respect be liable or answerable for the use made of the Special
Warrants or any of them or of the consideration thereof. Authentication by the Special Warrant Agent shall be conclusive evidence as against the Company that the Special Warrants so Authenticated have been duly issued hereunder and that the holder
thereof is entitled to the benefits of this Indenture. 

  

	 	(d)	 No Special Warrant Certificate shall be considered issued and Authenticated or, if Authenticated, shall be obligatory or shall entitle the holder
thereof to the benefits of this Indenture, until it has been Authenticated by manual signature by or on behalf of the Special Warrant Agent substantially in the form of the Special Warrant Certificate set out in Schedule “A” hereto. Such
Authentication on any such Special Warrant Certificate shall be conclusive evidence that such Special Warrant Certificate is duly Authenticated and is valid and a binding obligation of the Company and that the holder is entitled to the benefits of
this Indenture. 

  

	 	(e)	 No Uncertificated Warrant shall be considered issued and shall be obligatory or shall entitle the holder thereof to the benefits of this Indenture,
until it has been Authenticated by entry on the register of the particulars of the Uncertificated Warrant. Such entry on the register of the particulars of an Uncertificated Warrant shall be conclusive evidence that such Uncertificated Warrant is a
valid and binding obligation of the Company and that the holder is entitled to the benefits of this Indenture. 

  

	 	(f)	 Each CDS Global Warrant originally issued in Canada and held by the Depository, and each CDS Global Warrant issued in exchange therefor or in
substitution thereof shall bear or be deemed to bear the following legend or such variations thereof as the Company may prescribe from time to time: 

“UNLESS THIS CERTIFICATE IS PRESENTED BY AN AUTHORIZED REPRESENTATIVE OF CDS CLEARING AND DEPOSITORY SERVICES INC.
(“CDS”) TO ESSA PHARMA INC. (THE “ISSUER”) OR ITS AGENT FOR REGISTRATION OF TRANSFER, EXCHANGE OR PAYMENT, AND ANY CERTIFICATE ISSUED IN RESPECT THEREOF IS REGISTERED IN THE NAME OF CDS, OR IN SUCH OTHER NAME AS IS REQUESTED BY
AN AUTHORIZED REPRESENTATIVE OF CDS (AND ANY PAYMENT IS MADE TO CDS OR TO SUCH OTHER ENTITY AS IS REQUESTED BY AN AUTHORIZED REPRESENTATIVE OF CDS), ANY TRANSFER, PLEDGE OR OTHER USE HEREOF FOR VALUE OR OTHERWISE BY OR TO ANY PERSON IS WRONGFUL
SINCE THE REGISTERED HOLDER HEREOF, CDS, HAS A PROPERTY INTEREST IN THE SECURITIES REPRESENTED BY THIS CERTIFICATE HEREIN AND IT IS A VIOLATION OF ITS RIGHTS FOR ANOTHER PERSON TO HOLD, TRANSFER OR DEAL WITH THIS CERTIFICATE.” 

 

	2.5	 Transferability and Ownership of Special Warrants 

 

	 	(a)	 The Company hereby appoints the Special Warrant Agent as registrar of the Special Warrants, whether certificated or uncertificated, which shall
contain the information called for below with respect to each Special Warrant, together with such other information as may be required by law or as the Special Warrant Agent may elect to record. All such information shall be kept in one set of
accounts and records, at the Special Warrant Agent’s Vancouver office set forth in Section 1.1, which the Special Warrant Agent shall designate (in such manner as shall permit it to be so identified as such by an unaffiliated party) as the
register of the holders of Special Warrants. The information to be entered for each account in the register of Special Warrants at any time shall include (without limitation): 

 

	 	(i)	 the name and address of the holder of the Special Warrants, the date of Authentication thereof and the number of Special Warrants;

  
 9 

	 	(ii)	 whether such Special Warrant is certificated or uncertificated and, if certificated, the unique number or code assigned to and imprinted thereupon
and, if an uncertificated, the unique number or code assigned thereto if any; 

  

	 	(iii)	 whether such Special Warrant has been cancelled; and 

  

	 	(iv)	 a register of transfers in which all transfers of Special Warrants and the date and other particulars of each transfer shall be entered.

 The register shall be available for inspection by the Company and or any Special Warrantholder during
the Special Warrant Agent’s regular business hours on a Business Day and upon payment to the Special Warrant Agent of its reasonable fees. Any Special Warrantholder exercising such right of inspection shall first provide an affidavit in form
satisfactory to the Company and the Special Warrant Agent stating the name and address of the Special Warrantholder and agreeing not to use the information therein except in connection with an effort to call a meeting of Special Warrantholders or to
influence the voting of Special Warrantholders at any meeting of Special Warrantholders. 
  

	 	(b)	 Once an Uncertificated Warrant has been Authenticated, the information set forth in the register with respect thereto at the time of Authentication
may be altered, modified, amended, supplemented or otherwise changed only to reflect exercise or proper instructions to the Special Warrant Agent from the holder as provided herein, except that the Special Warrant Agent may act unilaterally to make
purely administrative changes internal to the Special Warrant Agent and changes to correct errors. Each person who becomes a holder of an Uncertificated Warrant, by his, her or its acquisition thereof shall be deemed to have irrevocably
(i) consented to the foregoing authority of the Special Warrant Agent to make such minor error corrections and (ii) agreed to pay to the Special Warrant Agent, promptly upon written demand, the full amount of all loss and expense
(including without limitation reasonable legal fees of the Company and the Special Warrant Agent plus interest, at an appropriate then prevailing rate of interest to the Special Warrant Agent), sustained by the Company or the Special Warrant Agent
as a proximate result of such error if but only if and only to the extent that such present or former holder realized any benefit as a result of such error and could reasonably have prevented, forestalled or minimized such loss and expense by prompt
reporting of the error or avoidance of accepting benefits thereof whether or not such error is or should have been timely detected and corrected by the Special Warrant Agent; provided that no person who is a bona fide purchaser shall have any
such obligation to the Company or to the Special Warrant Agent. 

  

	 	(c)	 The Special Warrant Certificates may only be transferred by the Special Warrantholder (or its legal representatives or its attorney duly
appointed), in accordance with applicable laws and upon compliance with the conditions herein, on the register kept at the office of the Special Warrant Agent pursuant to Section 2.5(a) by delivering to the Special Warrant Agent’s
Vancouver office a duly executed Form of Transfer attached as Appendix 2 to the Special Warrant Certificate and complying with such other reasonable requirements as the Company and the Special Warrant Agent may prescribe and such transfer shall be
duly noted on the register by the Special Warrant Agent. In the case of Uncertificated Warrants, the Special Warrants may only be transferred in accordance with the procedures of the Depository under the book-entry only registration system.

  

	 	(d)	 Notwithstanding anything contained in this Indenture, in the Special Warrant Certificate or in any subscription agreements under which Special
Warrants were issued and sold, the Special Warrant Agent, relying solely on the Form of Transfer or such other reasonable requirements as the Company and Special Warrant Agent may prescribe pursuant to Section 2.5(b) or this Section shall not
register any transfer of a Special Warrant unless the transfer is made in compliance with this Section. 

  
 10 

	 	(e)	 If a Special Warrantholder (or any beneficial purchaser on whose behalf it is acting) decides to offer, sell, pledge or otherwise transfer any of
the Special Warrants represented by a Special Warrant Certificate bearing the legend set forth in Section 5.9(a) hereof, or any of the Warrant Shares underlying such Special Warrant Certificate, they may be offered, sold, pledged or otherwise
transferred only: 

  

	 	(i)	 to the Company; 

  

	 	(ii)	 outside the United States in compliance with the requirements of Rule 904 of Regulation S under the 1933 Act, as applicable, and in compliance with
applicable local laws and regulations; 

  

	 	(iii)	 pursuant to a registration statement that has been declared effective under the 1933 Act and is available for resale of the Special Warrants; or

  

	 	(iv)	 in compliance with an exemption from registration under the 1933 Act including Rule 144 or Rule 144A thereunder, if available, and, in each case,
in compliance with any applicable state securities laws. 

 provided that, in the event of a
transfer of Special Warrants pursuant to the foregoing clause (ii) or (iv), the Company will require a legal opinion of counsel of recognized standing, or other evidence, reasonably satisfactory to the Company that such transfer is exempt from
registration under the 1933 Act and applicable state securities laws; 
  

	 	(f)	 The Company shall direct the Special Warrant Agent as to matters related to the applicable hold periods and applicable securities legislation. The
Special Warrant Agent shall have no obligation to ensure or verify compliance with any applicable laws or regulatory requirements on the issue, exercise or transfer of any Special Warrants or any Warrant Shares or other securities issuable upon the
exercise of any Special Warrants. The Special Warrant Agent shall be entitled to process all proffered transfers and exercises of Special Warrants upon the presumption that such transfers or exercises are permissible pursuant to all applicable laws
and regulatory requirements and the terms of this Indenture. The Special Warrant Agent may assume for the purposes of this Indenture that the address on the register of Special Warrantholders of any Special Warrantholder is the actual address of
such Special Warrantholder and is also determinative of the Special Warrantholder’s residency and that the address of any transferee to whom any Special Warrants or any Warrant Shares are to be registered, as shown on the transfer document, is
the transferee’s actual address and is also determinative of the transferee’s residency. 

  

	 	(g)	 Upon any transfer of Special Warrants in accordance with the provisions of this Indenture, the Company shall covenant and agree with the Special
Warrant Agent, on behalf of the transferee holder and with the transferee holder, that the transferee holder is a permitted assignee of the transferring holder and, for greater certainty, shall be entitled to any contractual or other right of
withdrawal or rescission that may be available to such transferee holder under Applicable Legislation. Should a holder of Special Warrants or such transferee holder exercise any legal, statutory, contractual or other right of withdrawal or
rescission that may be available to it, the Special Warrant Agent shall not be responsible for ensuring the Special Warrants or the exercise of Special Warrants is cancelled and a refund of the holder’s funds is paid back to the holder. In such
cases, the holder shall seek a refund directly from the Company and subsequently, the Company shall instruct the Special Warrant Agent in writing, to cancel the Special Warrants or exercise transaction and any underlying shares on the register,
which may have already been issued upon the Special Warrant exercise. 

  

	 	(h)	 A person who furnishes evidence that he is, to the reasonable satisfaction of the Special Warrant Agent: 

 

	 	(i)	 the executor, administrator, heir or legal representative of the heirs of the estate of a deceased Special Warrantholder; 

  
 11 

	 	(ii)	 a guardian, committee, trustee, curator or tutor representing a Special Warrantholder who is an infant, an incompetent person or a missing person;
or 

  

	 	(iii)	 a liquidator or, a trustee in bankruptcy for, a Special Warrantholder, 

may, as hereinafter stated, by surrendering such evidence together with the Special Warrant Certificate in question to the
Special Warrant Agent (by delivery or mail as set forth in Section 9.1 hereof), and subject to such reasonable requirements as the Special Warrant Agent may prescribe and all applicable securities legislation and requirements of regulatory
authorities, become noted upon the register of Special Warrantholders. After receiving the surrendered Special Warrant Certificate and upon the person surrendering the Special Warrant Certificate meeting the requirements as hereinbefore set forth,
the Special Warrant Agent shall forthwith give written notice thereof together with confirmation as to the identity of the person entitled to become the holder to the Company. Forthwith after receiving written notice from the Special Warrant Agent
as aforesaid, the Company shall cause a new Special Warrant Certificate to be issued and sent to the new holder and the Special Warrant Agent shall alter the register of holders accordingly. 

 

	 	(i)	 The Company and the Special Warrant Agent shall deem and treat the registered holder of any Special Warrant as the absolute legal and beneficial
owner thereof for all purposes, free from all equities or rights of set off or counterclaim between the Company and any previous holder of such Special Warrant, save in respect of equities of which the Company is required to take notice by statute
or by order of a court of competent jurisdiction, and neither the Company nor the Special Warrant Agent is affected by any notice to the contrary. 

  

	 	(j)	 Subject to the provisions of this Indenture and applicable law, each Special Warrantholder is entitled to the rights and privileges attaching to
the Special Warrants, and the issue of the Warrant Shares by the Company on exercise of Special Warrants by any Special Warrantholder in accordance with the terms and conditions herein contained discharges all responsibilities of the Company and the
Special Warrant Agent with respect to such Special Warrants and neither the Company nor the Special Warrant Agent is bound to inquire into the title of any such registered holder. 

 

	 	(k)	 A reasonable charge will be levied on a presenter of a Special Warrant Certificate pursuant to this indenture for the transfer of any Special
Warrant. 

  

	 	(l)	 Notwithstanding any other provision of this Section 2.5, in connection with any transfer of Special Warrants, the transferor and transferee
shall comply with all reasonable requirements of the Special Warrant Agent as the Special Warrant Agent may deem necessary to secure the obligations of the transferee of such Special Warrants with respect to such transfer or the sale of such Special
Warrants to the Company pursuant to Section 2.12. 

  

	2.6	 Special Warrantholders Not Shareholders 

A Special Warrantholder is not deemed or regarded as a shareholder of the Company nor is such Special Warrantholder entitled to
any right or interest except as is expressly provided in this Indenture and in the Special Warrant Certificates. 
  

	2.7	 Signing of Special Warrants 

Any one director or officer of the Company shall sign the Special Warrant Certificates either manually or by facsimile or
electronic signature. A facsimile or other electronic signature upon any Special Warrant Certificate is, for all purposes hereof, deemed to be the signature of the person whose signature it purports to be and to have been signed at the time such
facsimile or electronic signature is reproduced. If a person whose signature, either manually, in facsimile or in other electronic format, appears on a Special Warrant Certificate is not a director or officer of the Company at the date of this
Indenture or at the date of the countersigning and delivery of such Special Warrant Certificate, such fact does not affect in any way the validity of the Special Warrants or the entitlement of the Special Warrantholder to the benefits of this
Indenture or of the Special Warrant Certificate. 

  
 12 

	2.8	 Countersigning 

The Special Warrant Agent shall countersign the Special Warrant Certificates and Authenticated Uncertificated Warrants upon the
written direction of the Company. No Special Warrant Certificate shall be issued, or if issued, is valid or exercisable or entitles the holder thereof to the benefits of this Indenture until the Special Warrant Certificate has been manually
countersigned by the Special Warrant Agent or the Uncertificated Warrant has been Authenticated by the Special Warrant Agent, as the case may be. The countersignature or Authentication by or on behalf of the Special Warrant Agent will be conclusive
evidence as against the Company that the Special Warrant Certificate so countersigned or Uncertificated Warrant so Authenticated has been duly issued hereunder and that the holder is entitled to the benefit hereof. The countersignature by or on
behalf of the Special Warrant Agent on any Special Warrant Certificate or the Authentication of any Uncertificated Warrant by or on behalf of the Special Warrant Agent is not to be construed as a representation or warranty by the Special Warrant
Agent as to the validity of this Indenture or of the Special Warrants or as to the performance by the Company of its obligations under this Indenture and the Special Warrant Agent is in no way liable or answerable for the use made of the Special
Warrants or the proceeds from the issuance thereof, except as specified by this Indenture. The countersignature or Authentication, as the case may be, by or on behalf of the Special Warrant Agent is, however, a representation and warranty of the
Special Warrant Agent that the Special Warrant Certificate has been duly countersigned by or on behalf of the Special Warrant Agent pursuant to the provisions of this Indenture. 

 

	2.9	 Loss, Mutilation, Destruction or Theft of Special Warrants 

In case any of the Special Warrant Certificates issued and countersigned hereunder is mutilated or lost, destroyed or stolen,
the Company, in its discretion, may issue and thereupon the Special Warrant Agent will countersign and deliver a new Special Warrant Certificate of like date and tenor, and bearing the same legend, as applicable, in exchange for and in place of the
one mutilated, lost, destroyed or stolen and upon surrender and cancellation of such mutilated Special Warrant Certificate or in lieu of and in substitution for such lost, destroyed or stolen Special Warrant Certificate and the substituted Special
Warrant Certificate entitles the holder thereof to the benefits hereof and ranks equally in accordance with its terms with all other Special Warrants issued hereunder. 

The Special Warrantholder applying for the issue of a new Special Warrant Certificate pursuant to this Section shall bear the
cost of the issue thereof and in case of loss, destruction or theft shall, as a condition precedent to the issue thereof, furnish to the Company and the Special Warrant Agent such evidence of ownership and of the loss, destruction or theft of the
Special Warrant Certificate so lost, destroyed or stolen as is satisfactory to the Company in their discretion. The Company and the Special Warrant Agent shall also, as a condition precedent to issuing a new Special Warrant Certificate, require such
applicant to furnish an indemnity and surety bond in amount and form satisfactory to the Company and Special Warrant Agent in their sole discretion, and the applicant shall pay the reasonable charges of the Company and the Special Warrant Agent in
connection therewith. 
  

	2.10	 Exchange of Special Warrants 

A Special Warrantholder may, upon compliance with the reasonable requirements of the Special Warrant Agent (including
compliance with applicable securities laws) at any time prior to the Deemed Exercise Time, by written instruction delivered to the Special Warrant Agent at the office of the Special Warrant Agent set forth in Section 1.1, exchange his Special
Warrant Certificates for Special Warrant Certificates evidencing Special Warrants in other denominations entitling the Special Warrantholder to acquire in the aggregate the same number of Warrant Shares to which it was entitled to acquire under the
Special Warrant Certificates so surrendered, in which case the Special Warrant Agent may make a charge sufficient to reimburse it for any government fees or charges required to be paid and such reasonable fees as the Special Warrant Agent may
determine for every Special Warrant Certificate issued upon exchange. The Special Warrantholder surrendering such Special Warrant Certificate shall bear such fee and charge. Payment of the charges is a condition precedent to the exchange of the
Special Warrant Certificate. The Company shall sign and the Special Warrant Agent shall countersign all Special Warrant Certificates necessary to carry out exchanges as aforesaid. 

Special Warrant Certificates exchanged for Special Warrant Certificates that bear the legend set forth in Section 5.9 shall bear the same
legend. 

  
 13 

	2.11	 Ranking 

All Special Warrants will have the same attributes and rank pari passu regardless of the date of actual issue. 

 

	2.12	 Purchase of Special Warrants for Cancellation 

Subject to applicable law, the Company may, at any time or from time to time, purchase all or any of the Special Warrants in
the market, by private contract or otherwise, on such terms as the Company may determine and as agreed to by the holder of such Special Warrants. The Special Warrant Certificates representing the Special Warrants purchased hereunder by the Company
shall immediately following purchase, be delivered to and cancelled by the Special Warrant Agent and no Special Warrants shall be issued in substitution therefor. In the case of Uncertificated Warrants, the Special Warrants purchased pursuant to
this Section 2.12 shall be reflected accordingly on the register of the Special Warrants and in accordance with procedures prescribed by the Depository under the book-entry registration system. No Special Warrants shall be issued in replacement
thereof. 
  

	2.13	 Cancellation of Surrendered Special Warrants 

All Special Warrant Certificates surrendered pursuant to Article 5 shall be cancelled by the Special Warrant Agent and upon
such circumstances all such Uncertificated Warrants shall be deemed cancelled and so noted on the register by the Special Warrant Agent. 
  

	3.	 REPRESENTATIONS, WARRANTIES AND COVENANTS OF THE COMPANY 

So long as any Special Warrants remain outstanding, the Company represents, warrants, covenants and agrees with the Special
Warrant Agent for the benefit of the Special Warrant Agent and Special Warrantholders as follows: 
  

	3.1	 To Issue Special Warrants and Reserve Common Shares 

That it is duly authorized to create and issue the Special Warrants and that the Special Warrants, when issued and
countersigned by the Special Warrant Agent, will be valid and enforceable against the Company in accordance with their terms and the terms of this Indenture and that, subject to the provisions of this Indenture, the Company shall cause the Warrant
Shares acquired pursuant to the exercise or deemed exercise of Special Warrants and the certificates representing such securities, to be duly issued and delivered in accordance with the terms of the Special Warrants and this Indenture without
payment of additional consideration by the Special Warrantholders. At all times while any of the Special Warrants are outstanding, the Company shall reserve and allot out of its authorized capital a number of Common Shares sufficient to enable the
Company to meet its obligations to issue Warrant Shares in respect of the exercise or deemed exercise of all Special Warrants outstanding from time to time. All Warrant Shares acquired pursuant to the exercise or deemed exercise of the Special
Warrants shall be fully paid and non-assessable and free and clear of all encumbrances arising through or under the Company. 
  

	3.2	 To Execute Further Assurances 

That it shall do, execute, acknowledge and deliver or cause to be done, executed, acknowledged and delivered, all other acts,
deeds and assurances in law as may reasonably be required for the better accomplishing and effecting of the intentions and provisions of this Indenture. 
  

	3.3	 To Carry On Business 

That subject to the express provisions hereof, the Company and any Subsidiary of the Company shall carry on and conduct and
shall cause to be carried on and conducted its business in the same manner as heretofore carried on and conducted and in accordance with industry standards and good business practice, provided, however, that the Company or any Subsidiary of
the Company may cease to operate or may dispose of any business, premises, property, assets or operation if in the opinion of the directors or officers of the Company or any Subsidiary of the Company, as the case may be, it would be advisable and in
the best interests of the Company or any Subsidiary of the Company, as the case may be, to do so, and subject to the express provisions hereof, it shall do or cause to be 

  
 14 

 
done all things necessary to preserve and keep in full force and effect its corporate existence, provided, however, that (subject to Article 4 hereof) nothing herein contained shall
prevent the amalgamation, consolidation, merger, sale, winding-up or liquidation of the Company or any Subsidiary of the Company or the abandonment of any rights and franchises of the Company or any Subsidiary of the Company if, in the opinion of
the directors or officers of the Company or any Subsidiary of the Company, as the case may be, it is advisable and in the best interest of the Company or of such Subsidiary of the Company to do so. 

 

	3.4	 No Breach of Constating Documents 

That the issue and sale of the Special Warrants and the issue of the Warrant Shares do not or will not conflict with any of the
terms, conditions or provisions of the constating documents of the Company or the articles or resolutions of the Company or any trust indenture, loan agreement or any other agreement or instrument to which the Company or any Subsidiary is
contractually bound as of the date of this Indenture. 
  

	3.5	 Notices to Special Warrant Agent 

That, at least one Business Day prior to the U.S. Listing Date, the Company shall: 

 

	 	(a)	 give written notice to the Special Warrant Agent and the Agent of the U.S. Listing Date; and 

 

	 	(b)	 if applicable, provide written confirmation to the Special Warrant Agent and the Agent of any adjustment that has been made pursuant to
Article 4. 

  

	3.6	 Securities Qualification Requirements 

That if any instrument is required to be filed with or any permission, order or ruling is required to be obtained from the
Commissions or any other step is required under any federal or provincial law of the Designated Provinces before any securities or property which a Special Warrantholder is entitled to receive pursuant to the exercise or deemed exercise of a Special
Warrant may properly and legally be delivered upon the due exercise or deemed exercise of a Special Warrant, the Company covenants that it shall use its reasonable best efforts to make such filing, obtain such permission, order or ruling and take
all such action, at its expense, as is required or appropriate in the circumstances. 
  

	3.7	 Satisfy Covenants 

That the Company will comply with all covenants and satisfy all terms and conditions on its part to be performed and satisfied
under this Indenture and advise the Special Warrant Agent promptly in writing of any default under the terms of this Indenture. 
  

	3.8	 Performance of Covenants by Special Warrant Agent 

If the Company shall fail to perform any of its covenants contained in this Indenture and the Company has not rectified such
failure within ten Business Days after receiving notice of such failure by the Special Warrant Agent, the Special Warrant Agent may notify the Special Warrantholders of such failure on the part of the Company or may itself perform any of the
covenants capable of being performed by it but, shall be under no obligation to perform said covenants or to notify the Special Warrantholders of such performance by it. No such performance, expenditure or advance by the Special Warrant Agent shall
relieve the Company of any default hereunder or of its continuing obligations under the covenants herein contained. 
  

	3.9	 Special Warrant Agent’s Remuneration and Expenses 

The Company will pay the Special Warrant Agent from time to time such reasonable remuneration for its services hereunder as may
be agreed upon between the Company and the Special Warrant Agent and will pay or reimburse the Special Warrant Agent upon its request for all reasonable expenses and disbursements and advances properly incurred or made by the Special Warrant Agent
in the administration or execution of the trusts hereby created (including the reasonable compensation and disbursements of its counsel and all other advisers and assistants not regularly in its employ), both before any default hereunder and
thereafter until all duties of the Special Warrant 

  
 15 

 
Agent hereunder shall be finally and fully performed, except any such expense, disbursement advance as may arise from the gross negligence or wilful misconduct of the Special Warrant Agent. Any
amount owing hereunder and remaining unpaid after 30 calendar days from the invoice date will bear interest at the then current rate charged by the Special Warrant Agent against unpaid invoices and shall be payable upon demand. This Section shall
survive the resignation of the Special Warrant Agent and/or the termination of this Indenture. 
  

	3.10	 Trust for Special Warrantholder’s Benefit 

The covenants of the Company to the Special Warrant Agent provided for in this Indenture shall be held in trust by the Special
Warrant Agent for the benefit of the Special Warrantholders. 
  

	3.11	 Notice to Special Warrantholders of Certain Events 

The Company covenants with the Special Warrant Agent for the benefit of the Special Warrant Agent and the Special
Warrantholders that, so long as any of the Special Warrants are outstanding, it will not: 
  

	 	(a)	 pay any dividend payable in shares of any class to the holders of its Common Shares or make any other distribution (other than a cash distribution
made as a dividend out of retained earnings or contributed surplus legally available for the payment of dividends) to the holders of its Common Shares; 

  

	 	(b)	 offer to the holders of its Common Shares rights to subscribe for or to purchase any Common Shares or shares of any class or any other securities,
rights, warrants or options; 

  

	 	(c)	 make any repayment of capital on, or distribution of evidences of indebtedness on, any of its assets (excluding cash dividends) to the holders of
Common Shares; 

  

	 	(d)	 amalgamate, consolidate or merge with any other person or sell or lease the whole or substantially the whole of its assets or undertaking;

  

	 	(e)	 effect any subdivision, consolidation or reclassification of its Common Shares; or 

 

	 	(f)	 liquidate, dissolve or wind-up, 

unless, in each such case, the Company will have given notice, in the manner specified in Section 9.2, to each Special Warrantholder, of
the action proposed to be taken and the date on which (a) the books of the Company will close or a record will be taken for such dividend, repayment, distribution, subscription rights or other rights, warrants or securities, or (b) such
subdivision, consolidation, reclassification, amalgamation, merger, sale or lease, dissolution, liquidation or winding-up will take place, as the case may be, provided that the Company will only be
required to specify in the notice those particulars of the action as will have been fixed and determined at the date on which the notice is given. The notice will also specify the date as of which the holders of Common Shares of record will
participate in the dividend, repayment, distribution, subscription of rights or other rights, warrants or securities, or will be entitled to exchange their Common Shares for securities or other property deliverable upon such reclassification,
amalgamation, merger, sale or lease, other disposition, dissolution, liquidation or winding-up, as the case may be. The notice will be given, with respect to the actions described in Sections (a), (b), (c), (d), (e) and (f) above not less
than 10 calendar days prior to the record date or the date on which the Company’s transfer books are to be closed with respect thereto. 
  

	3.12	 Closure of Share Transfer Books 

The Company further covenants and agrees that it will not during the period of any notice given under Section 9 close its
share transfer books or take any other corporate action which might deprive the Special Warrantholders of the opportunity of exercising their Special Warrants; provided that nothing contained in this Section 3.12 will be deemed to affect
the right of the Company to do or take part in any of the things referred to in Section 3.11 or to pay cash dividends on the shares of any class or clauses in its capital from time to time outstanding. 

  
 16 

	3.13	 Payment of Commissions 

The Company will not pay or give any commission or other remuneration within the meaning of Section 3(a)(9) of the 1933
Act to any person, directly or indirectly, for soliciting the exercise of the Special Warrants. 
  

	3.14	 Registration under the 1934 Act 

The Company warrants and covenants that, prior to listing the Common Shares on NASDAQ or the NYSE, all of the issued and
outstanding Common Shares will be registered under the 1934 Act. 
  

	4.	 ADJUSTMENT OF NUMBER OF WARRANT SHARES 

  

	4.1	 Adjustment of Number of Warrant Shares 

The rights to acquire Warrant Shares in effect at any date attaching to the Special Warrants are subject to adjustment from
time to time as follows: 
  

	 	(a)	 if and whenever at any time from the date hereof and prior to the Deemed Exercise Time, the Company: 

 

	 	(i)	 subdivides, redivides or changes its outstanding Common Shares into a greater number of shares; 

 

	 	(ii)	 consolidates, reduces or combines its outstanding Common Shares into a smaller number of shares; or 

 

	 	(iii)	 issues Common Shares or securities exchangeable for or convertible to Common Shares (“convertible securities”) to the holders of
all or substantially all of the outstanding Common Shares by way of a stock dividend (other than the issue of Common Shares or convertible securities to such holders as Dividends paid in the Ordinary Course); 

(any of the above being a “Common Share Reorganization”), the number of Warrant Shares issuable upon the
exercise of each Special Warrant is adjusted immediately after the effective date of the Common Share Reorganization or on the record date for the issue of Common Shares or convertible securities by way of stock dividend, by multiplying the number
of Warrant Shares previously obtainable on the exercise of a Special Warrant by the fraction of which: 
  

	 	(A)	 the numerator is the total number of Common Shares outstanding immediately after the effective or record date of the Common Share Reorganization,
or, in the case of the issuance of exchangeable or convertible securities, the total number of Common Shares outstanding immediately after the effective or record date of the Common Share Reorganization plus the total number of Common Shares
issuable upon conversion or exchange of such convertible securities; and 

  

	 	(B)	 the denominator is the total number of Common Shares outstanding immediately prior to the applicable effective or record date of such Common Share
Reorganization; 

 and the Company and Special Warrant Agent, upon receipt of notice pursuant to
Section 4.4, shall make such adjustment successively whenever any event referred to in this Section 4.1(a) occurs and any such issue of Common Shares or convertible securities by way of a stock dividend is deemed to have occurred on the
record date for the stock dividend for the purpose of calculating the number of outstanding Common Shares under this Section 4.1(a). To the extent that any convertible securities are not converted into or exchanged for Common Shares, prior to
the expiration thereof, the number of Warrant Shares obtainable under each Special Warrant shall be readjusted to the number of Warrant Shares that is then obtainable based upon the number of Common Shares actually issued on conversion or exchange
of such convertible securities; 

  
 17 

	 	(b)	 if and whenever at any time from the date hereof and prior to the Deemed Exercise Time the Company shall fix a record date for the issue of rights,
options or warrants to all or substantially all of the holders of Common Shares under which such holders are entitled, during a period expiring not more than 45 calendar days after the record date for such issue (“Rights
Period”), to subscribe for or acquire Common Shares at a price per share to the holder of less than 95% of the Current Market Price for the Common Shares on such record date (any of such events being called a “Rights
Offering”), then the number of Warrant Shares obtainable upon the exercise of each Special Warrant shall be adjusted effective immediately after the end of the Rights Period to a number determined by multiplying the number of Warrant Shares
obtainable upon the exercise thereof immediately prior to the end of the Rights Period by a fraction: 

  

	 	(i)	 the numerator of which shall be the number of Common Shares outstanding after giving effect to the Rights Offering and including the number of
Common Shares actually issued or subscribed for during the Rights Period upon exercise of the rights, warrants or options under the Rights Offering; and 

  

	 	(ii)	 the denominator of which shall be the aggregate of: 

  

	 	(A)	 the number of Common Shares outstanding as of the record date for the Rights Offering, and 

 

	 	(B)	 a number determined by dividing (1) the product of the number of Common Shares issued or subscribed during the Rights Period upon the exercise
of the rights, warrants, or options under the Rights Offering and the price at which such Common Shares are offered by (2) the Current Market Price of the Common Shares as of the record date for the Rights Offering; 

 

	 	(c)	 if and whenever at any time from the date hereof and prior to the Deemed Exercise Time the Company shall issue or distribute to all or to
substantially all of the holders of the Common Shares: 

  

	 	(i)	 securities of the Company including rights, options or warrants to acquire shares of any class or securities exchangeable for or convertible into
or exchangeable into any such shares or property or assets and including evidence of its indebtedness; or 

  

	 	(ii)	 any property (including cash) or other assets, 

and if such issuance or distribution does not constitute Dividends paid in the Ordinary Course, a Common Share Reorganization
or a Rights Offering (any of such non-excluded events being herein called a “Special Distribution”), the number of Warrant Shares obtainable upon the exercise of each Special Warrant shall be adjusted effective immediately after the
record date at which the holders of affected Common Shares are determined for purposes of the Special Distribution to a number determined by multiplying the number of Warrant Shares obtainable upon the exercise thereof in effect on such record date
by a fraction: 
  

	 	(iii)	 the numerator of which shall be the number of Common Shares outstanding on such record date multiplied by the Current Market Price of the Common
Shares on such record date; and 

  

	 	(iv)	 the denominator of which shall be: 

  

	 	(A)	 the product of the number of Common Shares outstanding on such record date and the Current Market Price of the Common Shares on such record date,
less 

  

	 	(B)	 the excess, if any, of (1) the fair market value on such record date, as determined by action by the directors (whose determination shall be
conclusive), to the holders of the Common Shares of such securities or property or other assets so issued or distributed in the Special Distribution over (2) the fair market value of the consideration received therefor by the Company from the
holders of the Common Shares, as determined by action by the directors (whose determination shall be conclusive); 

  
 18 

	 	(d)	 if and whenever at any time from the date hereof and prior to the Deemed Exercise Time, there is a reclassification of the Common Shares or a
change in the Common Shares into other shares or securities, or a capital reorganization of the Company other than as described in Section 4.1(a) or the triggering of a shareholders’ rights plan or a consolidation, amalgamation,
arrangement or merger of the Company with or into any other body corporate, trust, partnership or other entity, or a transfer, sale or conveyance of the property and assets of the Company as an entirety or substantially as an entirety to any other
body corporate, trust, partnership or other entity, any of such events being referred to as a “Capital Reorganization”, every Special Warrantholder who has not exercised its right of acquisition, as at the effective date of such Capital
Reorganization is entitled to receive upon exercise in accordance with the terms and conditions hereof and shall accept, in lieu of the number of Warrant Shares obtainable under the Special Warrants to which it was previously entitled, the kind and
number of Warrant Shares or other securities or property of the Company that the Special Warrantholder would have been entitled to receive on such Capital Reorganization, if, on the record date or the effective date thereof, as the case may be, the
Special Warrantholder had been the registered holder of the number of Warrant Shares obtainable upon the exercise of Special Warrants then held, subject to adjustment thereafter in accordance with provisions of the same, as nearly as may be
possible, as those contained in this Section 4.1. The Company shall not carry into effect any action requiring an adjustment pursuant to this Section 4.1(d) unless all necessary steps have been taken so that the Special Warrantholders are
thereafter entitled to receive such kind and number of Warrant Shares, other securities or property. The Company will not enter into a Capital Reorganization unless its successor, or the purchasing body corporate, partnership, trust or other entity,
as the case may be, prior to or contemporaneously with any such Capital Reorganization, enters into an indenture which provides, to the extent possible, for the application of the provisions set forth in this Indenture with respect to the rights and
interests thereafter of the Special Warrantholders to the end that the provisions set forth in this Indenture are correspondingly made applicable, as nearly as may reasonably be, with respect to any shares, other securities or property to which a
Special Warrantholder is entitled on the exercise of his acquisition rights thereafter. An indenture entered into by the Company pursuant to the provisions of this Section 4.1(d) is deemed a supplemental indenture entered into pursuant to the
provisions of Article 7. An indenture entered into between the Company, any successor to the Company or any purchasing body corporate, partnership, trust or other entity and the Special Warrant Agent must provide for adjustments which are as
nearly equivalent as may be practicable to the adjustments provided in this Section 4.1 and which apply to successive Capital Reorganizations; 

  

	 	(e)	 where this Section 4.1 requires that an adjustment becomes effective immediately after a record date or effective date, as the case may be,
for an event referred to herein, the Company may defer, until the occurrence of that event, issuing to the Special Warrantholder exercising his acquisition rights after the record date or effective date, as the case may be and before the occurrence
of that event the adjusted number of Warrant Shares, other securities or property issuable upon the exercise or deemed exercise of the Special Warrants by reason of the adjustment required by that event. If the Company relies on this
Section 4.1(e) to defer issuing an adjusted number of Warrant Shares, other securities or property to a Special Warrantholder, the Special Warrantholder has the right to receive any distributions made on the adjusted number of Warrant Shares,
other securities or property declared in favour of holders of record on and after the date of exercise or such later date as the Special Warrantholder would, but for the provisions of this Section 4.1(e), have become the holder of record of the
adjusted number of Warrant Shares, other securities or property; 

  
 19 

	 	(f)	 the adjustments provided for in this Section 4.1 are cumulative. After any adjustment pursuant to this Section 4.1, the term
“Warrant Shares” where used in this Indenture is interpreted to mean securities of any class or classes which, as a result of such adjustment and all prior adjustments pursuant to this Section, the Special Warrantholder is entitled to
receive upon the exercise of his Special Warrant, and the number of Warrant Shares obtainable in any exercise made pursuant to a Special Warrant is interpreted to mean the number of Warrant Shares or other property or securities a Special
Warrantholder is entitled to receive, as a result of such adjustment and all prior adjustments pursuant to this Section 4.1, upon the full exercise of a Special Warrant; 

 

	 	(g)	 notwithstanding anything in this Article 4, no adjustment shall be made in the acquisition rights attached to the Special Warrants if the issue of
Common Shares is being made pursuant to any stock option or stock purchase plan in force from time to time for directors, officers or employees of the Company; 

 

	 	(h)	 in the event of a question arising with respect to the adjustments provided for in this Section 4.1, that question shall be conclusively
determined by the Company’s auditors who shall have access to all necessary records of the Company, and a determination by the Company’s auditors is binding upon the Company, the Special Warrant Agent, all Special Warrantholders and all
other persons interested therein; and 

  

	 	(i)	 no adjustment in the number of Warrant Shares obtainable upon exercise of Special Warrants shall be made in respect of any event described in this
Section 4.1, other than the events referred in clauses (i) and (ii) of Section (b) thereof, if the Special Warrantholders are entitled to participate in such event on the same terms, mutatis mutandis, as if the Special
Warrantholders had exercised their Special Warrants prior to or on the effective date or record date of such event. 

  

	4.2	 Adjustment if U.S. Listing Date does not Occur on or Prior to the Deadline Date 

Should the U.S. Listing Date not occur on or prior to the Deadline Date, then following the Deadline Date (including, for the
avoidance of doubt, the Deemed Exercise Time), as to each Warrant Share underlying each Special Warrant immediately prior to the Deadline Date, such Special Warrant shall entitle the holder thereof to obtain 1.5 Warrant Shares upon deemed exercise
thereof. The foregoing adjustment shall be in addition to any adjustment provided for in Section 4.1 and shall be applied after giving effect to the adjustments provided for in Section 4.1. 

 

	4.3	 Proceedings Prior to any Action Requiring Adjustment 

As a condition precedent to the taking of any action which requires an adjustment in any of the acquisition rights pursuant to
the Special Warrants, including the number of Warrant Shares obtainable upon the exercise or deemed exercise thereof, the Company shall take any corporate action which may in its opinion be necessary in order that the Company or any successor to the
Company has unissued and reserved Common Shares in its authorized capital and may validly and legally issue as fully paid and non-assessable all the Warrant Shares and may validly and legally deliver all other securities or property which the
Special Warrantholders are entitled to receive on the full exercise of the Special Warrants in accordance with the provisions hereof. 
  

	4.4	 Certificate of Adjustment 

The Company shall from time to time immediately after the occurrence of any event which requires an adjustment as provided in
Section 4.1 or Section 4.2, deliver a notice to the Special Warrantholders and the Special Warrant Agent specifying the nature of the event requiring the adjustment, the amount of the adjustment necessitated thereby, and setting forth in
reasonable detail the method of calculation and the facts upon which the calculation is based. In the event of a dispute about such calculation, the certificate shall be supported by a certificate of the Company’s auditors verifying such
calculation. The Special Warrant Agent shall rely, and shall be protected in so doing, upon the certificate of the Company or the Company’s auditor and any other document filed by the Company pursuant to this Article 4 for all purposes. 

  
 20 

	4.5	 No Action After Notice 

The Company covenants with the Special Warrant Agent that it will not close its transfer books or take any other corporate
action which might deprive the holder of a Special Warrant of the opportunity of exercising the Special Warrants during the period of 14 calendar days after giving of the notice set forth in Section 4.4 hereof and 4.7 hereof. 

 

	4.6	 Protection of Special Warrant Agent 

The Special Warrant Agent shall not: 
  

	 	(a)	 at any time be under any duty or responsibility to a Special Warrantholder to determine whether any facts exist which require any adjustment
contemplated by Section 4.1 or Section 4.2, or with respect to the nature or extent of any such adjustment when made, or with respect to the method employed in making the same; 

 

	 	(b)	 be accountable with respect to the validity or value (or the kind or amount) of any shares or other securities or property which may at any time be
issued or delivered upon the exercise of the rights attaching to any Special Warrant; 

  

	 	(c)	 be responsible for any failure of the Company to make any cash payment or to issue, transfer or deliver Warrant Shares or certificates for the
Warrant Shares upon the surrender of any Special Warrants for the purpose of the exercise of such rights or to comply with any of the covenants contained in this Article 4; and 

 

	 	(d)	 shall not incur any liability or responsibility whatsoever or be in any way responsible for the consequence of any breach on the part of the
Company of any of the representations, warranties or covenants herein contained or of any acts of the Agent or servants of the Company. 

  

	4.7	 Notice of Special Matters 

The Company covenants with the Special Warrant Agent that so long as any Special Warrants remain outstanding it will give
notice, not less than 14 calendar days prior to the applicable record date, in the manner provided for in Article 9 to the Special Warrant Agent, each Special Warrantholder and to the Agent of any event which requires an adjustment to the
subscription rights attaching to any of the Special Warrants pursuant to this Article 4. The Company covenants and agrees that such notice shall contain the particulars of such event in reasonable detail and, if determinable, the required adjustment
in the manner provided for in Article 9. The Company further covenants and agrees that it shall promptly, as soon as the adjustment calculations are reasonably determinable, file a certificate of the Company with the Special Warrant Agent showing
how such adjustment shall be computed. 
  

	5.	 EXERCISE, RETRACTION AND CANCELLATION OF SPECIAL WARRANTS 

 

	5.1	 Notice of Deemed Exercise to Special Warrantholders 

Upon receipt of notice from the Company in accordance with Section 3.5, the Special Warrant Agent shall give written
notice, in the form to be provided by the Company to the Special Warrant Agent, to each Special Warrantholder, which notice will include a statement that any Special Warrants not exercised prior to the Deemed Exercise Time will be deemed to be
exercised pursuant to Section 5.3 and will include confirmation that no adjustment has occurred pursuant to Section 4.1 or Section 4.2, or if an adjustment has occurred, provide a certificate as set forth in Section 4.4 herein.

  

	5.2	 Voluntary Exercise of Special Warrants 

A Special Warrantholder may, at any time before the Deemed Exercise Time, exercise all or any number of the Special Warrants
outstanding which are then held by the Special Warrantholder, by surrendering to the Special Warrant Agent, at its principal transfer office in the City of Vancouver or at such additional place or places as may

  
 21 

 
be designated by the Company from time to time with the approval of the Special Warrant Agent during normal Business Hours on a Business Day, the Special Warrant Certificate or Special Warrant
Certificates representing the number of Special Warrants to be exercised, together with a duly completed and executed exercise form(s) in the form attached as Appendix 1 to the Special Warrant Certificate(s) in accordance with the instructions
attached as Appendix 4 to the Special Warrant Certificate and subject to compliance with such requirements as the Special Warrant Agent may reasonably impose to permit the tracking of such exercises from time to time. Voluntary exercise at a time
prior to the date that is four months and one day after the Closing Date is subject to compliance with, and may be restricted by, the securities laws of the Designated Provinces and is further subject to the Special Warrantholders providing such
assurances and executing such documents as may, in the reasonable opinion of the Company or the Special Warrant Agent, be required to ensure compliance with applicable securities laws. If, at the time of the voluntary exercise of the Special
Warrants pursuant to this Section 5.2, there remain restrictions on resale under applicable securities laws on the Warrant Shares so acquired, the Company, may, if required on the advice of counsel, endorse the certificates representing the
Warrant Shares with respect to those restrictions. Upon the voluntary exercise of Special Warrants pursuant to this Section 5.2, the Special Warrant Agent shall promptly thereafter and in any event within three Business Days: 

 

	 	(a)	 deliver certificates for the Warrant Shares to the address of the Special Warrantholder specified in the register of Special Warrants;

  

	 	(b)	 if so specified, deliver certificates for the Warrant Shares to the Special Warrantholder at the principal office of the Special Warrant Agent in
Vancouver, British Columbia; or 

  

	 	(c)	 deliver certificates for the Warrant Shares to the address of the Special Warrantholder specified in writing by the Special Warrantholder to the
Special Warrant Agent. 

 The exercise form attached to the Special Warrant Certificate shall not be
deemed to be duly completed if the name and mailing address of the holder do not appear legibly on such exercise form and such exercise form is not signed by the Special Warrantholder, his executor, administrator or other legal representative of
such holder’s attorney duly appointed. 
 Exercise notices must be delivered to the Special Warrant Agent at any time
during the Special Warrant Agent’s actual business hours on any Business Day prior to the Deemed Exercise Date. Any exercise notice received by the Special Warrant Agent after business hours on any Business Day other than the Deemed Exercise
Date will be deemed to have been received by the Special Warrant Agent on the next following Business Day. 
 Should an
exercise be processed through the Depository prior to the date that is four months and one calendar day after the Closing Date, the holder shall be required to withdraw its position from the Depository and receive from the Special Warrant Agent a
Special Warrant Certificate representing the Special Warrants so withdrawn. Such holder shall then be permitted to exercise its Special Warrants in accordance with this Section 5.2. 

 

	5.3	 Deemed Exercise of Special Warrants 

All Special Warrants not exercised by the Special Warrantholder pursuant to Section 5.2 prior to the Deemed Exercise Time
will be deemed to be exercised at the Deemed Exercise Time and deemed to have been surrendered by the Special Warrantholder without any further action on the part of the Special Warrantholder. In that event, the Special Warrant Agent shall, within
three Business Days thereafter, deliver in certificated form the Warrant Shares issued upon deemed exercise of the Special Warrants, registered in the name of the Special Warrantholders, to the addresses of the Special Warrantholders as specified in
the register for the Special Warrants or to such address as the Special Warrantholder may specify in writing to the Special Warrant Agent. 
  

	5.4	 Effect of Exercise of Special Warrants 

Upon the exercise or deemed exercise of the Special Warrants, each Special Warrantholder is, at that time, deemed to have
become the holder or holders of record of the Warrant Shares, in respect of which such Special Warrantholder’s Special Warrants are exercised or are deemed to have been exercised, unless the transfer registers of the Company shall be closed by
law on such date, in which case the Warrant Shares acquired shall be deemed to have been issued and such person or persons deemed to have become the holder or holders of record of such Warrant Shares on the date on which such transfer registers are
next reopened. 

  
 22 

 Notwithstanding any provision herein to the contrary, the Company shall not be
required to deliver certificates for Warrant Shares in any period while the share transfer registers of the Company are closed and, in the event of the exercise of any Special Warrant during any such period, the Warrant Shares subscribed for shall
be issued and such person shall be deemed to have become the holder of record of such Warrant Shares on the date on which such share transfer registers are reopened. 
  

	5.5	 Partial Exercise 

Any Special Warrantholder may acquire a number of Warrant Shares less than the number of Warrant Shares which the holder is
entitled to acquire pursuant to the surrendered Special Warrant Certificate(s). In the event of any exercise of a number of Special Warrants less than the number which the holder is entitled to exercise pursuant to the surrendered Special Warrant
Certificates, the Special Warrantholder upon such exercise shall, in addition to the number of Warrant Shares acquired pursuant to the Special Warrants exercised, be entitled to receive, without charge therefor, a new Special Warrant Certificate(s)
in respect of the balance of the Special Warrants represented by the surrendered Special Warrant Certificate(s) and which were not then exercised. 
  

	5.6	 Special Warrants Void After Exercise Time 

After the exercise or deemed exercise of a Special Warrant as provided in this Section, except as otherwise provided herein,
the holder of a Special Warrant Certificate representing the Special Warrant so exercised no longer has any rights either under this Indenture or the Special Warrant Certificate, other than, the right to receive certificates representing the Warrant
Shares, and the Special Warrant is void and of no value or effect. 
  

	5.7	 Fractions of Warrant Shares 

  

	 	(a)	 Where a Special Warrantholder is entitled to receive, as a result of the adjustments provided for in Section 4.1 or Section 4.2 or
otherwise, on the exercise or partial exercise of its Special Warrants a fraction of a Warrant Share, such right may only be exercised in respect of such fraction in combination with another Special Warrant or other Special Warrants which in the
aggregate entitle the Special Warrantholder to receive a whole number of Warrant Shares; and 

  

	 	(b)	 If a Special Warrantholder is not able to, or elects not to, combine Special Warrants so as to be entitled to acquire a whole number of Warrant
Shares, the Special Warrantholder may not exercise the right to acquire a fractional Warrant Share, and, as a result, has the right to acquire only that number of Warrant Shares equal to the next lowest whole number of Warrant Shares and no cash
will be paid in lieu of any fractional Warrant Share. 

  

	5.8	 Accounting and Recording 

The Special Warrant Agent shall promptly notify the Company with respect to Special Warrants exercised. The Special Warrant
Agent shall record the particulars of the Special Warrants exercised which include the name or names and addresses of the persons who become holders of Warrant Shares on exercise pursuant to this Article 5 and the number of Warrant Shares
issued. Within three Business Days of the exercise of each Special Warrant pursuant to Section 5.2, the Special Warrant Agent shall provide those particulars in writing to the Company. 

  
 23 

	5.9	 Legending of Special Warrant Certificates and Underlying Securities 

 

	 	(a)	 The Special Warrants and Warrant Shares have not been, and will not be, registered under the 1933 Act or applicable securities laws of any state of
the United States. Each Special Warrant Certificate and each certificate representing the Warrant Shares originally issued to or for the account or benefit of a person in the United States, and each Special Warrant Certificate and each certificate
representing the Warrant Shares issued in exchange therefor or in substitution thereof, shall bear the following additional legend (the “U.S. Legend”) until such time as the U.S. Legend is no longer required under applicable
requirements of the 1933 Act or applicable state securities laws: 

 “THE SECURITIES REPRESENTED
HEREBY [AND IF SPECIAL WARRANTS, THE FOLLOWING SHALL BE ADDED: AND THE SECURITIES ISSUABLE UPON EXERCISE HEREOF] HAVE NOT BEEN AND WILL NOT BE REGISTERED UNDER THE UNITED STATES SECURITIES ACT OF 1933, AS AMENDED (THE “U.S. SECURITIES
ACT”) OR ANY STATE SECURITIES LAWS, AND MAY BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED ONLY (A) TO THE CORPORATION (B) OUTSIDE THE UNITED STATES IN COMPLIANCE WITH RULE 904 OF REGULATION S UNDER THE U.S. SECURITIES ACT AND IN
COMPLIANCE WITH LOCAL LAWS AND REGULATIONS, (C) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE U.S. SECURITIES ACT AND IS AVAILABLE FOR RESALE OF THE SECURITIES, OR (D) IN COMPLIANCE WITH AN EXEMPTION FROM
REGISTRATION UNDER THE U.S. SECURITIES ACT, INCLUDING RULE 144 OR RULE 144A THEREUNDER, IF AVAILABLE, AND, IN EACH CASE, IN COMPLIANCE WITH ANY APPLICABLE STATE SECURITIES LAWS. THE HOLDER FURTHER UNDERSTANDS AND AGREES THAT IN THE EVENT OF A
TRANSFER PURSUANT TO THE FOREGOING CLAUSE (B) OR (D), THE CORPORATION WILL REQUIRE A LEGAL OPINION OF COUNSEL OF RECOGNIZED STANDING OR OTHER EVIDENCE REASONABLY SATISFACTORY TO THE CORPORATION THAT SUCH TRANSFER IS EXEMPT FROM REGISTRATION
UNDER THE U.S. SECURITIES ACT AND APPLICABLE STATE SECURITIES LAWS. DELIVERY OF THIS CERTIFICATE MAY NOT CONSTITUTE “GOOD DELIVERY” IN SETTLEMENT OF TRANSACTIONS ON STOCK EXCHANGES IN CANADA.” 

provided that if any of the Special Warrants or the Warrant Shares are being distributed outside of the United States
in accordance with Rule 904 of Regulation S under the 1933 Act, and provided that the Company is a “foreign issuer” within the meaning of Regulation S under the 1933 Act at the time of sale, the legend may be removed by providing a
declaration to the Company and either the Special Warrant Agent (in the case of the Special Warrants) or the Company’s transfer agent (in the case of the Warrant Shares) in the form attached hereto as Appendix 3 to the Special Warrant
Certificate (or as the Company, acting reasonably, may prescribe from time to time) in addition to such other evidence of exemption as the Company and the Special Warrant Agent or the Company’s transfer agent (as the case may be) may require
from time to time, which may include an opinion of counsel in form and substance satisfactory to the Company; 
 provided
further, that, if any of the Special Warrants or the Warrant Shares are being sold pursuant to Rule 144 under the U.S. Securities Act or are eligible to be sold by the holder therefor pursuant to Rule 144 under the U.S. Securities Act without
restriction thereunder, the legend may be removed by delivery to the Company and the Special Warrant Agent (in the case of the Special Warrants) or the Company’s transfer agent (in the case of the Warrant Shares) of an opinion of counsel of
recognized standing in form and substance satisfactory to the Company, to the effect that the legend is no longer required under applicable requirements of the 1933 Act and state securities laws. 

The Special Warrant Agent shall be entitled to request any other documents that it may require in accordance with its internal
policies of the removal of the legend set forth above. 
  

	 	(b)	 All Special Warrant Certificates and all certificates issued in exchange therefor or in substitution thereof will have the following additional
legend endorsed thereon: 

 “UNLESS PERMITTED UNDER SECURITIES LEGISLATION, THE HOLDER OF THIS
SECURITY MUST NOT TRADE THE SECURITY BEFORE THE DATE THAT IS 4 MONTHS AND ONE DAY AFTER THE [DATE OF DISTRIBUTION OF THE SPECIAL WARRANTS]” 

  
 24 

	 	(c)	 Notwithstanding any other provisions of this Indenture, in processing and registering transfers of Special Warrants, no duty or responsibility
whatsoever shall rest upon the Special Warrant Agent to determine the compliance by any transferor or transferee with the terms of the legend contained in this Section 5.9, or with the relevant securities laws or regulations, including, without
limitation, Regulation S, and the Special Warrant Agent shall be entitled to assume that all transfers are legal and proper. 

  

	5.10	 Issuance of Warrant Shares 

Any certificates representing the Warrant Shares issued prior to the date which is four months and one calendar day after the
original date of issuance of Special Warrants will have one or both of the following legends endorsed thereon: 

“UNLESS PERMITTED UNDER SECURITIES LEGISLATION, THE HOLDER OF THIS SECURITY MUST NOT TRADE THE SECURITY BEFORE THE
DATE THAT IS 4 MONTHS AND ONE DAY AFTER THE ORIGINAL DATE OF DISTRIBUTION OF THE SPECIAL WARRANT(S).” 

“WITHOUT PRIOR WRITTEN APPROVAL OF THE TSX VENTURE EXCHANGE AND COMPLIANCE WITH ALL APPLICABLE SECURITIES LEGISLATION,
THE SECURITIES REPRESENTED BY THIS CERTIFICATE MAY NOT BE SOLD, TRANSFERRED, HYPOTHECATED OR OTHERWISE TRADED ON OR THROUGH THE FACILITIES OF THE TSX VENTURE EXCHANGE OR OTHERWISE IN CANADA OR TO OR FOR THE BENEFIT OF A CANADIAN RESIDENT UNTIL [4
MONTHS AND ONE DAY AFTER THE ORIGINAL DATE OF DISTRIBUTION OF THE SPECIAL WARRANT(S)].” 
 In addition, all Warrant
Shares issued upon exercise or deemed exercise of Special Warrants that bear the legend set forth in Section 5.9(a) shall be endorsed with the same legend. 
  

	5.11	 Securities Restrictions 

Notwithstanding anything herein contained, in the event that the Special Warrants are exercised pursuant to and in accordance
with the provisions of Section 5.2 prior to the date that is 4 months and one calendar day after the Closing Date, the certificates representing the Warrant Shares thereby issued will bear such legends as may, in the opinion of counsel to the
Company, acting reasonably, be necessary in order to avoid a violation of any applicable securities laws or to comply with the requirements of any stock exchange on which the Common Shares are listed, provided that, if at any time, in the
opinion of counsel to the Company, such legends are no longer necessary in order to avoid violation of such laws, or the holder of any such legended certificates representing the Warrant Shares, at the holder’s expense, provides the Company and
the registrar and transfer agent of the Common Shares with evidence satisfactory in form and substance to the Company and the registrar and transfer agent of the Common Shares (which may include an opinion of counsel satisfactory to the Company and
the registrar and transfer agent of the Common Shares) to the effect that such holder is entitled to sell or otherwise transfer such Warrant Shares in a transaction in which such legends are not required, such legended certificates representing
Warrant Shares may thereafter be surrendered to the Special Warrant Agent in exchange for a certificate which does not bear such legend. 
  

	5.12	 Mandatory Purchase for Cancellation and Voluntary Retraction 

 

	 	(a)	 Mandatory Purchase for Cancellation upon Wind-up, Liquidation or Dissolution. In the event of a wind-up, liquidation or dissolution
of the Company prior to the Automatic Exercise Date, if permitted by applicable laws, each outstanding Special Warrant shall be purchased for cancellation by the Company immediately prior to such wind-up, liquidation or dissolution at the Purchase
Price. To effect such purchase for cancellation, at least five Business Days prior to such wind-up, liquidation or dissolution, the Company will deliver to the Special Warrant Agent notice of such purchase for cancellation and, subject to
Section 5.12(c), a certified cheque to the order of the Special Warrant Agent in an amount equal to the Purchase Price multiplied by the number of 

  
 25 

	 	 
Special Warrants then outstanding. Within three Business Days of the receipt of such notice and funds, the Special Warrant Agent will send to each Special Warrantholder at its address as
specified in the register of Special Warrants payment by cheque in an amount equal to the Purchase Price multiplied by the number of outstanding Special Warrants held by such Special Warrantholder. The Company will pay the Special Warrant Agent the
estimated charges and expenses to be incurred in connection with such purchase for cancellation forthwith. If any question arises as to whether notice of purchase for cancellation or the purchase for cancellation funds have been given or made
available as provided above, such question will be decided by the Special Warrant Agent, whose decision will be final and binding upon all interested parties. All Special Warrants purchased for cancellation shall be cancelled by the Special Warrant
Agent and no Warrant Shares will be issued in substitution therefor. 

  

	 	(b)	 Voluntary Retraction upon a Change of Control. At any time prior to the expiration of the Retraction Period, each Special
Warrantholder shall have the right to require the Company to redeem any or all of the Special Warrants outstanding on the date of such retraction and held by such Special Warrantholder at an amount equal to the Voluntary Retraction Price multiplied
by the number of Special Warrants so redeemed. 

  

	 	(i)	 Notice of Change of Control. Within one Business Day of a Change of Control, the Company shall give written notice to the Special Warrant
Agent and the Agent of the date of such Change of Control and the date of the expiration of the Retraction Period. Upon receipt of notice from the Company in accordance with the preceding sentence, the Special Warrant Agent shall, within three
Business Days thereafter, deliver written notice, in the form to be provided by the Company to the Special Warrant Agent, to each holder of an outstanding Special Warrant at the addresses of the Special Warrantholders as specified in the register
for the Special Warrants or to such address as each Special Warrantholder may specify in writing to the Special Warrant Agent. 

  

	 	(ii)	 Mechanics of Retraction. Special Warrantholders may exercise the retraction privilege provided for in this Section 5.12(b) by, at any
time during the Retraction Period, surrendering the Special Warrant Certificate at the office of the Special Warrant Agent, together with written notice that such Special Warrantholder elects to redeem all or any number of the Special Warrants
represented by such Special Warrant Certificate or Certificates. Such notice shall be signed by such Special Warrantholder or its agent. 

If such Special Warrantholder alleges that a Special Warrant Certificate has been lost, stolen or destroyed, as a condition
precedent to the retraction thereof, such Special Warrantholder shall furnish to the Company and the Special Warrant Agent during the Retraction Period such evidence of ownership and of the loss, destruction or theft of the Special Warrant
Certificate so lost, destroyed or stolen as is satisfactory to the Company in its discretion, acting reasonably. The Company and the Special Warrant Agent shall also, as a condition precedent to redeeming Special Warrants represented by a lost,
stolen or destroyed Special Warrant Certificate, require such applicant to furnish an indemnity and surety bond in amount and form satisfactory to the Company and Special Warrant Agent in their sole discretion, acting reasonably, and the applicant
shall pay the reasonable charges of the Company and the Special Warrant Agent in connection therewith. 
 Within three
Business Days after the expiration of the Retraction Period, the Special Warrant Agent shall provide written notice to the Company stating the number of Special Warrants surrendered for retraction and the names of the Special Warrantholders thereof.
Subject to Section 5.12(c), the Company shall, within five Business Days of receipt of such notice from the Special Warrant Agent, deliver to the Special Warrant Agent a certified cheque to the order of the Special Warrant Agent in an aggregate
amount equal to the Voluntary Retraction Price multiplied by the number of Special Warrants to be redeemed. Within three Business Days of the receipt of such funds, the Special Warrant Agent will send to each Special Warrantholder at its address as
specified in the register of Special Warrants payment by cheque in an amount equal to the Voluntary Retraction 

  
 26 

 
Price multiplied by the number of Special Warrants surrendered for retraction by such Special Warrantholder. The Special Warrant Certificates representing such Special Warrants shall thereupon be
cancelled and the Special Warrants represented thereby shall thereupon be cancelled. The Company will pay the Special Warrant Agent the estimated charges and expenses to be incurred in connection with such retraction forthwith. If any question
arises as to whether the retraction funds have been given or made available as provided above, such question will be decided by the Special Warrant Agent, whose decision will be final and binding upon all interested parties. 

From and after the date a Special Warrantholder surrenders to the Special Warrant Agent any Special Warrants for retraction in
accordance with this Section 5.12(b), the Special Warrantholder shall not be entitled to exercise any of the rights of Special Warrantholders in respect of such Special Warrants unless payment of the Voluntary Retraction Price in respect of
such Special Warrants is not made to the Special Warrantholder within 15 Business Days of the expiration of the Retraction Period, in which case the rights of the Special Warrantholder of such Special Warrants shall remain unaffected until the
Special Warrant Agent has delivered to such former Special Warrantholder payment in full of the Voluntary Retraction Price multiplied by the number of Special Warrants so redeemed. 

 

	 	(c)	 Insufficient Funds. If the funds of the Company legally available for purchase for cancellation or retraction, as the case may be, of
the Special Warrants are insufficient to purchase or redeem the total number of Special Warrants to be purchased or for which Special Warrantholders have submitted notices of retraction to the Special Warrant Agent during the Retraction Period, as
the case may be, those funds that are legally available will be used by the Special Warrant Agent to purchase or redeem the maximum possible number of whole Special Warrants rateably among the Special Warrantholders. The Special Warrants not
purchased or redeemed will remain outstanding and remain entitled to all rights and preferences otherwise provided in this Special Warrant Indenture. As and when funds legally available for purchase or retraction of Special Warrants subsequently
become available, those funds will be paid by the Company to the Special Agent forthwith and used by the Special Warrant Agent to purchase or redeem the maximum possible number of whole Special Warrants rateably among the remaining Special
Warrantholders, in the case of a purchase for cancellation, or the Special Warrantholders whose Special Warrants were submitted to the Special Warrant Agent with a notice of retraction during the Retraction Period but not yet redeemed, in the case
of a retraction. The Special Warrant Agent shall have no obligation to ensure sufficient funds are legally available to purchase or redeem the total number of Special Warrants to be purchased or for which Special Warrantholders have submitted
notices of retraction to the Special Warrant Agent, as the case may be. 

  

	6.	 MEETINGS OF SPECIAL WARRANTHOLDERS 

  

	6.1	 Definitions 

In this Article 6 or otherwise in this Indenture: 

 

	 	(a)	 “Adjourned Meeting” means a meeting adjourned in accordance with Section 6.8; 

 

	 	(b)	 “Extraordinary Resolution” means a resolution proposed to be passed as an extraordinary resolution at a Meeting duly convened for
that purpose and held in accordance with the provisions of this Article 6, and carried by not less than 2/3 of the votes cast on such resolution; and 

  

	 	(c)	 “Meeting” means a meeting of the Special Warrantholders. 

 

	6.2	 Convening Meetings 

The Special Warrant Agent or the Company may convene a Meeting at any time at the expense of the Company. Upon receipt of a
written requisition signed in one or more counterparts by Special Warrantholders     

  
 27 

 
having the right to acquire not less than 25% of the Warrant Shares which may be acquired hereunder, the Special Warrant Agent or the Company shall convene a Meeting, provided that in the
case of the Special Warrant Agent, it has been indemnified and funded to its reasonable satisfaction by the Company or the Special Warrantholders for the costs of convening and holding a Meeting. If the Special Warrant Agent or the Company fails to
convene the Meeting within 15 Business Days after being duly requisitioned to do so and indemnified and funded as aforesaid, the Special Warrantholders having the right to acquire not less than 25% of the Warrant Shares which may be acquired
hereunder may themselves convene a Meeting, the notice for which must be signed by a person that those Special Warrantholders specify, provided that the Special Warrant Agent and Company receive notice of the Meeting in accordance with
Section 6.4. A written requisition must state, generally, the reason for the Meeting and business to be transacted at the Meeting. 
  

	6.3	 Place of Meeting 

Every Meeting must be held in Vancouver, British Columbia or at such other place that the Special Warrant Agent and Company
approve. 
  

	6.4	 Notice 

The Special Warrant Agent or the Company, as the case may be, shall give written notice of each Meeting to each Special
Warrantholder, the Special Warrant Agent (unless the Meeting has been called by the Special Warrant Agent), the Agent and the Company (unless the Meeting has been called by the Company) in the manner specified in Article 9 at least 25 calendar
days before the date of the Meeting. The Special Warrant Agent shall give written notice of each Adjourned Meeting to each Special Warrantholder in the manner specified in Article 9 at least 7 calendar days before the date of the Adjourned
Meeting. The notice for a Meeting must state the time and place of the Meeting and, generally, the reason for the Meeting and the business to be transacted at the Meeting, together with such additional information as may be required to sufficiently
inform the Special Warrantholders regarding the business to be transacted at the Meeting. The notice for an Adjourned Meeting must state the time and place of the Adjourned Meeting but need not specify the business to be transacted at an Adjourned
Meeting. The accidental omission by the Special Warrant Agent or the Company, as the case may be, to give notice of a Meeting or an Adjourned Meeting to a Special Warrantholder does not invalidate a resolution passed at a Meeting or Adjourned
Meeting. 
  

	6.5	 Persons Entitled to Attend 

The Company and the Agent may and the Special Warrant Agent shall, each by its authorized representatives, attend every Meeting
and Adjourned Meeting but neither the Company, the Agent nor the Special Warrant Agent has the right to vote. The legal advisors of the Company, the Agent, the Special Warrant Agent, and any Special Warrantholders, respectively, may also attend a
Meeting or Adjourned Meeting but do not have the right to vote, unless they have the right to vote as a Special Warrantholder. 
  

	6.6	 Quorum 

Subject to the provisions of Section 6.18, a quorum for a Meeting shall consist of two or more persons present in person
and owning or representing by proxy the right to acquire, not less than 25% of the Warrant Shares which may be acquired hereunder. 
  

	6.7	 Chairman 

The Special Warrant Agent shall nominate a natural person as the chairman of a Meeting or Adjourned Meeting. If the person so
nominated is not present within 15 minutes after the time set for holding the Meeting or Adjourned Meeting, the Special Warrantholders and proxies for Special Warrantholders present shall choose one of their number to be chairman. The chairman may
vote any Special Warrants for which he or she is the registered holder. 

  
 28 

	6.8	 Power to Adjourn 

The chairman of any Meeting at which a quorum of the Special Warrantholders is present may, with the consent of the Meeting,
adjourn any such meeting. Notice of such adjournment will be given in accordance with Section 6.4 with such other requirements, if any, as the Meeting may prescribe. 
  

	6.9	 Adjourned Meeting 

If a quorum of the Special Warrantholders is not present within 30 minutes after the time fixed for holding a Meeting, the
Meeting stands adjourned to a date not less than 10 calendar days and not more than 30 calendar days later, at a place determined in accordance with Section 6.3, and at a time specified by the chairman. The Special Warrant Agent shall promptly
and in accordance with Section 6.4 send a notice of the Adjourned Meeting to each Special Warrantholder and the Company. At an Adjourned Meeting, two or more Special Warrantholders or persons representing Special Warrantholders by proxy
constitutes a quorum for the transaction of business for which the Meeting was convened. 
  

	6.10	 Show of Hands 

Subject to a poll and except as otherwise required herein, every question submitted to a Meeting or Adjourned Meeting, except
an Extraordinary Resolution, shall be decided, in the first instance, by the majority of votes in a show of hands. If the vote is tied, the chairman does not have a casting vote and the motion will not be carried. On a show of hands, each Special
Warrantholder present in person or represented by proxy and entitled to vote is entitled to one vote for every Special Warrant then outstanding of which such Special Warrantholder is the registered owner. 

 

	6.11	 Poll 

When requested by a Special Warrantholder acting in person or by the proxy representing the Special Warrantholder, and on every
Extraordinary Resolution, the chairman of a Meeting or Adjourned Meeting shall request a poll on a question submitted to the Meeting. Except as otherwise required herein, if a question has been put to a poll, that question shall be decided by the
affirmative vote of not less than a majority of the votes given on the poll. If the vote is tied, the motion shall not be carried. On a poll, each Special Warrantholder or person representing a Special Warrantholder shall be entitled to one vote for
every Warrant Share which he or she is entitled to acquire upon exercise of the Special Warrants of which he is the registered holder. A declaration made by the chairman that a resolution has been carried or lost is conclusive evidence thereof. In
the case of joint registered Special Warrantholders, any one of them present in person or represented by proxy may vote in the absence of the other or others but when more than one of them is present in person or by proxy, they may only vote
together in respect of the Special Warrants of which they are joint registered holders. 
  

	6.12	 Regulations 

Subject to the provisions of this Indenture, the Special Warrant Agent, or the Company with the approval of the Special Warrant
Agent, may from time to time make and, thereafter, vary regulations not contrary to the provisions of this Indenture as it deems fit providing for and governing the following: 
  

	 	(a)	 setting a record date for a Meeting for determining Special Warrantholders entitled to receive notice of and vote at a Meeting;

  

	 	(b)	 voting by proxy, the manner in which a proxy instrument must be executed, and the production of the authority of any person signing an instrument
of a proxy on behalf of a Special Warrantholder; 

  

	 	(c)	 lodging and the means of forwarding the instruments appointing proxies, and the time before a Meeting or Adjourned Meeting by which an instrument
appointing a proxy must be deposited; 

  

	 	(d)	 the form of the instrument of proxy; and 

  

	 	(e)	 any other matter relating to the conduct of a meeting of Special Warrantholders. 

  
 29 

 A regulation so made is binding and effective and votes given in accordance with
such a regulation are valid. The Special Warrant Agent may permit Special Warrantholders to make proof of ownership in the manner the Special Warrant Agent approves. 
  

	6.13	 Powers of Special Warrantholders 

By Extraordinary Resolution passed pursuant to this Article 6, the Special Warrantholders may: 

 

	 	(a)	 agree to any modification, abrogation, alteration, compromise, or arrangement of the rights of the Special Warrantholders whether arising under
this Indenture, or otherwise at law, including the rights of the Special Warrant Agent in its capacity as trustee hereunder or on behalf of the Special Warrantholders against the Company, which has been agreed to by the Company;

  

	 	(b)	 direct and authorize the Special Warrant Agent to exercise any discretion, power, right, remedy or authority given to it by or under this Indenture
in the manner specified in such resolution or to refrain from exercising any such discretion, power, right, remedy, or authority; 

  

	 	(c)	 direct the Special Warrant Agent to enforce any covenant or obligation on the part of the Company contained in this Indenture or to waive any
default by the Company in compliance with any provision of this Indenture either unconditionally or upon any conditions specified in such resolution; 

  

	 	(d)	 assent to any change in or omission from the provisions contained in this Indenture or the Special Warrant Certificates or any ancillary or
supplemental instrument which is agreed to by the Company, and to authorize the Special Warrant Agent to concur in and execute any ancillary or supplemental indenture embodying the change or omission; 

 

	 	(e)	 without limiting the generality of Sections 6.13(a) and (d), assent to an extension of time thereunder; 

 

	 	(f)	 with the consent of the Company, remove the Special Warrant Agent or its successor in office and to appoint a new registrar and trustee to take the
place of the Special Warrant Agent so removed; 

  

	 	(g)	 upon the Special Warrant Agent being furnished with funding and an indemnity that is, in its discretion, sufficient, require the Special Warrant
Agent to enforce any covenant of the Company contained in this Indenture or the Special Warrant Certificates, or to enforce any right of the Special Warrantholders in any manner specified in such Extraordinary Resolution, or to refrain from
enforcing any such covenant or right; 

  

	 	(h)	 restrain any Special Warrantholder from instituting or continuing any suit or proceeding against the Company for the enforcement of a covenant on
the part of the Company contained in this Indenture or any of the rights conferred upon the Special Warrantholders as set out in this Indenture or the Special Warrant Certificates; 

 

	 	(i)	 direct a Special Warrantholder who, as such, has brought a suit, action or proceeding to stay or discontinue or otherwise deal with the same upon
payment of the costs, charges, and expenses reasonably and properly incurred by such Special Warrantholder in connection therewith; 

  

	 	(j)	 waive and direct the Special Warrant Agent to waive a default by the Company in complying with any of the provisions of this Indenture or the
Special Warrant Certificate either unconditionally or upon any conditions specified in such Extraordinary Resolution; 

  

	 	(k)	 assent to a compromise or arrangement with a creditor or creditors or a class or classes of creditors, whether secured or otherwise, and with
holders of any shares or other securities of the Company; or 

  

	 	(l)	 amend, alter, or repeal any Extraordinary Resolution previously passed pursuant to this Section 6.13. 

  
 30 

	6.14	 Powers Cumulative 

Any one or more of the powers or any combination of the powers in this Indenture stated to be exercised by the Special
Warrantholders by Extraordinary Resolution or otherwise may be exercised from time to time and the exercise of any one or more of such powers or any combination of powers from time to time shall not be deemed to exhaust the right of the Special
Warrantholder to exercise such power or combination of powers then or thereafter from time to time. 
  

	6.15	 Minutes of Meetings 

The Special Warrant Agent shall make and maintain minutes and records of all resolutions and proceedings at a Meeting or
Adjourned Meeting at the expense of the Company and shall make available those minutes and records at the office of the Special Warrant Agent for inspection by a Special Warrantholder or his authorized representative and the Agent at reasonable
times. If signed by the chairman of the Meeting or by the chairman of the next succeeding Meeting, such minutes shall be prima facie evidence of the matters therein stated and, until the contrary is proved, every such Meeting in respect of which
minutes shall have been made shall be deemed to have been duly convened and held, and all the resolutions passed thereat or proceedings taken shall be deemed to have been duly passed and taken. 

 

	6.16	 Written Resolutions 

Notwithstanding the foregoing, a written resolution or instrument signed in one or more counterparts by the Special
Warrantholders holding the right to acquire not less than a majority of the Warrant Shares which may be acquired hereunder in the case of a resolution, or not less than 2/3 of the Warrant Shares which may be acquired hereunder in the case of an
Extraordinary Resolution, is deemed to be the same as, and to have the same force and effect as, a resolution or Extraordinary Resolution, as the case may be, duly passed at a Meeting or Adjourned Meeting. 

 

	6.17	 Binding Effect 

A resolution of the Special Warrantholders passed pursuant to this Article 6 is binding upon all Special Warrantholders.
Upon the passing of a Special Warrantholder’s resolution at a meeting of the Special Warrantholders, or upon the signing of a written resolution or instrument pursuant to Section 6.16 and delivery by the Company to the Special Warrant
Agent of an original, certified or notarial copy, or copies, of such resolution as executed or passed by the Special Warrantholders, the Special Warrant Agent is entitled to and shall give effect thereto. 

 

	6.18	 Holdings by the Company or Subsidiaries of the Company Disregarded 

In determining whether Special Warrantholders holding Special Warrants evidencing the required number of Warrant Shares which
may be acquired pursuant to the exercise of the Special Warrants are present at a meeting of Special Warrantholders for the purpose of determining a quorum or have concurred in any consent, waiver, resolution, Extraordinary Resolution or other
action under this Indenture, Special Warrants owned legally or beneficially by the Company or any subsidiary of the Company shall be disregarded. 
  

	7.	 SUPPLEMENTAL INDENTURES, MERGER, SUCCESSORS 

  

	7.1	 Provision for Supplemental Indentures for Certain Purposes 

From time to time the Company shall, when authorized by the directors of the Company and the Special Warrant Agent may, subject
to the provisions of this Indenture, execute and deliver by their proper officers, deeds, indentures or instruments supplemental hereto, which thereafter form part hereof for any one or more or all of the following purposes: 

 

	 	(a)	 adding to the provisions hereof such additional covenants, enforcement provisions, and release provisions (if any) as in the opinion of counsel
acceptable to the Company and the Special Warrant Agent are necessary or advisable, provided the same are not, in the opinion of counsel to the Special Warrant Agent prejudicial to the interests of the Special Warrantholders; 

  
 31 

	 	(b)	 adding to the covenants of the Company in this Indenture for the protection of the Special Warrantholders; 

 

	 	(c)	 evidencing any succession (or successive successions), of other companies to the Company and the covenants of, and obligations assumed by, such
successor (or successors) in accordance with the provisions of this Indenture; 

  

	 	(d)	 setting forth any adjustments resulting from the application of the provisions of Article 4; 

 

	 	(e)	 making such provisions not inconsistent with this Indenture as may be deemed necessary or desirable with respect to matters or questions arising
hereunder, provided that such provisions are not, in the opinion of counsel to the Special Warrant Agent, prejudicial to the interests of the Special Warrantholders; 

 

	 	(f)	 giving effect to an Extraordinary Resolution; 

  

	 	(g)	 to rectify any ambiguity, defective provision, clerical omission or mistake or manifest or other error contained herein or in any deed or indenture
supplemental or ancillary hereto provided that, in the opinion of the counsel to the Special Warrant Agent, the rights of the Special Warrantholders are not prejudiced thereby; 

 

	 	(h)	 adding to or altering the provisions hereof in respect of the transfer of Special Warrants, making provision for the exchange of Special Warrant
Certificates of different denominations, and making any modification in the form of the Special Warrant Certificate which does not affect the substance thereof; or 

 

	 	(i)	 for any other purpose not inconsistent with the provisions of this Indenture, provided that, in the opinion of counsel to the Special
Warrant Agent, the rights of the Special Warrantholders are in no way prejudiced thereby. 

  

	7.2	 Company May Consolidate, etc. on Certain Terms 

Subject to Section 4.1(d), nothing in this Indenture prevents any consolidation, amalgamation, arrangement or merger of
the Company with or into any other body corporate or bodies corporate, or a conveyance or transfer of all or substantially all the properties and assets of the Company as an entirety to any body corporate lawfully entitled to acquire and operate the
same, provided, however, that the body corporate formed by such consolidation, amalgamation, arrangement or into which such merger has been made, or which has acquired by conveyance or transfer all or substantially all the properties and
assets of the Company as an entirety in circumstances resulting in the Special Warrantholders being entitled to receive property from or securities of such body corporate, shall execute prior to or contemporaneously with such consolidation,
amalgamation, arrangement, merger, conveyance or transfer, an indenture supplemental hereto wherein the due and punctual performance and observance of all the covenants and conditions of this Indenture to be performed or observed by the Company are
assumed by the successor body corporate. The Special Warrant Agent is entitled to receive and is fully protected in relying upon an opinion of counsel that any such consolidation, amalgamation, arrangement, merger, conveyance or transfer, and a
supplemental indenture executed in connection therewith, complies with the provisions of this Section. 
  

	7.3	 Successor Body Corporate Substituted 

Where the Company, pursuant to Section 7.2 hereof, is consolidated, amalgamated, arranged or merged with or into any other
body corporate or bodies corporate or conveys or transfers all of substantially all of the properties and assets of the Company as an entirety to another body corporate, the successor body corporate formed by such consolidation,
amalgamation, arrangement or into which the Company has been merged or which has 

  
 32 

 
received a conveyance or transfer as aforesaid succeeds to and is substituted for the Company hereunder with the same effect as nearly as may be possible as if it had been named herein. Such
changes may be made in the Special Warrants as may be appropriate in view of such consolidation, amalgamation, arrangement, merger, conveyance or transfer. 
  

	8.	 CONCERNING THE SPECIAL WARRANT AGENT 

  

	8.1	 Duties of Special Warrant Agent 

By way of supplement to the provisions of any statute for the time being relating to trustees, and notwithstanding any other
provision of this Indenture, in the exercise of the rights, duties and obligations prescribed or conferred by the terms of this Indenture, the Special Warrant Agent shall act honestly and in good faith with a view to the best interests of the
Special Warrantholders and shall exercise that degree of care, diligence and skill that a reasonably prudent trustee would exercise in comparable circumstances. No provision of this Indenture shall be construed to relieve the Special Warrant Agent
from, or require any other person to indemnify the Special Warrant Agent against any liability for its own gross negligence, wilful misconduct or fraud. 
  

	8.2	 Action by Special Warrant Agent 

The Special Warrant Agent is not obligated to do any act or thing except where required to do so by this Indenture and, in the
case of a default, only when it has actual notice thereof. 
  

	8.3	 Certificate of the Company 

If in the administration of the trusts of this Indenture, the Special Warrant Agent deems it necessary or desirable that any
matter be proved or established by the Company, prior to taking or suffering any action hereunder, the Special Warrant Agent may accept and rely on a certificate of the Company, resolutions, opinions, orders or other documents as conclusive evidence
of the truth of any fact relating to the Company or its assets therein stated and proof of the regularity of any proceedings or actions associated therewith, but the Special Warrant Agent may in its discretion require further evidence or information
before acting or relying on any such certificate. 
  

	8.4	 Special Warrant Agent May Employ Experts 

The Special Warrant Agent may, at the Company’s expense, employ or retain such lawyers, accountants, engineers, appraisers
or other experts, advisers or Agent as it may reasonably require for the purpose of discharging its duties hereunder and may pay reasonable remuneration for such services rendered to it but it is not responsible for any misconduct, mistake or error
of judgment on the part of any of them. The Company shall reimburse the Special Warrant Agent for all reasonable disbursements, costs and expenses made or incurred by the Special Warrant Agent in the discharge of its duties and in the management of
the trusts hereunder. The Special Warrant Agent may rely upon and act upon the opinion or advice of, or information obtained from, any such lawyer, accountant, engineer, appraiser or other expert, adviser or agent in relation to any matter arising
in the administration of the trusts hereof. The Special Warrant Agent shall not incur any liability for the acts or omissions of such lawyers, accountants, engineers, appraisers or other experts, advisers or Agent employed by the Special Warrant
Agent in good faith. 
  

	8.5	 Resignation and Replacement of Special Warrant Agent 

 

	 	(a)	 The Special Warrant Agent may resign its trust and be discharged from all further obligations hereunder by giving to the Company and the Special
Warrantholders written notice at least 60 calendar days, or such shorter time period if acceptable to the Special Warrant Agent, the Company and the Special Warrantholders, before the effective date of the resignation. If the Special Warrant Agent
resigns, or becomes incapable of acting hereunder, the Company shall forthwith appoint in writing a new trustee. Failing such appointment by the Company or by the Special Warrantholders by Extraordinary Resolution, the retiring Special Warrant Agent
or any Special Warrantholder may apply to a judge of the Supreme Court of British Columbia on such notice as such judge may direct, for the appointment of a new trustee. The Special Warrantholders may, by Extraordinary Resolution, remove the Special
Warrant Agent (including a trustee 

  
 33 

	 	 
appointed by the Company or by a judge as aforesaid) and appoint a new trustee. On any new appointment, the new trustee is vested with the same powers, rights, duties and obligations as if it had
been originally named as Special Warrant Agent without any further assurance, conveyance, act or deed. If for any reason it becomes necessary or expedient to execute any further deed or assurance, the former Special Warrant Agent shall execute the
same in favour of the new trustee. 

  

	 	(b)	 Any company resulting from a merger, consolidation, arrangement or amalgamation to which the Special Warrant Agent for the time being is a party
shall be the successor Special Warrant Agent under this Indenture without any further act. 

  

	8.6	 Indenture Legislation 

The Company and the Special Warrant Agent agree that each shall at all times in relation to this Indenture and to any action to
be taken hereunder, observe and comply with and be entitled to the benefits of all Applicable Legislation. If and to the extent that any provision of this Indenture limits, qualifies or conflicts with any mandatory requirement of Applicable
Legislation, such mandatory requirement prevails. 
  

	8.7	 Notice 

The Special Warrant Agent is not required to give notice to third parties, including the Special Warrantholders, of the
execution of this Indenture. 
  

	8.8	 Use of Proceeds 

The Special Warrant Agent is in no way responsible for the use by the Company of the proceeds of the issue hereunder. 

 

	8.9	 No Inquiries 

In the exercise of any right or duty hereunder the Special Warrant Agent, if it is acting in good faith, may act and rely, as
to the truth of any statement or the accuracy of any opinion expressed therein, on any statutory declaration, opinion, report, certificate or other evidence furnished to the Special Warrant Agent pursuant to a provision hereof or of Applicable
Legislation or pursuant to a request of the Special Warrant Agent, if such evidence complies with Applicable Legislation and the Special Warrant Agent examines such evidence and determines that it complies with the applicable requirements of this
Indenture. The Special Warrant Agent may nevertheless, in its discretion, require further proof in cases where it deems further proof desirable. The Special Warrant Agent is not bound to make any inquiry or investigation as to the performance by the
Company of the Company’s covenants hereunder. 
  

	8.10	 Actions by Special Warrant Agent to Protect Interest 

Subject to Section 8.13, the Special Warrant Agent shall have the power, but shall have no obligation, to institute and to
maintain such actions and proceedings as it may consider necessary or expedient to preserve, protect or enforce its interests and the interests of the Special Warrantholders. 
  

	8.11	 Special Warrant Agent Not Required to Give Security 

The Special Warrant Agent is not required to give any bonds or security with respect to the execution or administration of the
trusts and powers of this Indenture. 
  

	8.12	 No Conflict of Interest 

The Special Warrant Agent represents to the Company that, at the date of execution and delivery by it of this Indenture, there
exists no material conflict of interest in the role of the Special Warrant Agent as a fiduciary hereunder but if, notwithstanding the provisions of this Section 8.12, such a material conflict of interest exists, the validity and enforceability
of this Indenture and the instruments issued hereunder is not affected in any manner whatsoever by reason only that such material conflict of interest exists or arises. The Special Warrant Agent shall, within 30 calendar days after ascertaining that
it has a material conflict of interest, either eliminate such material conflict of interest or resign in the manner and with the effect specified in Section 8.5. 

  
 34 

	8.13	 Special Warrant Agent Not Ordinarily Bound 

No provision of this Indenture shall require the Special Warrant Agent to expend or risk its own funds or otherwise incur
financial liability in the performance of any of its duties or in the exercise of any of its rights or powers unless it is indemnified and funded to its satisfaction. The obligation of the Special Warrant Agent to commence or continue any act,
action or proceeding for the purpose of enforcing any rights of the Special Warrantholders hereunder, is conditional upon Special Warrantholders furnishing, when required in writing so to do by the Special Warrant Agent, an indemnity reasonably
satisfactory to the Special Warrant Agent, and funds sufficient for commencing or continuing the act, action or proceeding and an indemnity reasonably satisfactory to the Special Warrant Agent to protect and hold harmless the Special Warrant Agent
against any loss, damage or liability by reason thereof. 
  

	8.14	 Special Warrant Agent May Deal in Instruments 

The Special Warrant Agent may in its personal or other capacity, buy, sell, lend upon and deal in and hold securities of the
Company and generally contract and enter into financial transactions with the Company or otherwise, without being liable to account for any profits made thereby. 
  

	8.15	 Recitals or Statements of Fact Made by Company 

Except for the representations contained in Sections 8.12 and 8.19 subject to the provisions hereof, the Special Warrant
Agent is not liable for or by reason of any of the statements of fact or recitals contained in this Indenture or in the Special Warrant Certificates and is not required to verify the same but all such statements and recitals are and are deemed to
have been made by the Company only. 
  

	8.16	 Special Warrant Agent’s Discretion Absolute 

The Special Warrant Agent, except as herein otherwise provided, has, as regards all the trusts, powers, authorities and
discretions vested in it, absolute and uncontrolled discretion as to the exercise thereof, whether in relation to the manner or as to the mode and time for the exercise thereof. 

 

	8.17	 No Representations as to Validity 

The Special Warrant Agent is not: 
  

	 	(a)	 under any responsibility in respect of the validity of this Indenture or the execution and delivery thereof or (subject to Section 2.8 hereof)
in respect of the validity or the execution of any Special Warrant Certificate; 

  

	 	(b)	 responsible for any breach by the Company of any covenant or condition contained in this Indenture or in any Special Warrant Certificate; or

  

	 	(c)	 by any act hereunder, deemed to make any representation or warranty as to the authorization or reservation of any Warrant Shares to be issued as
provided in this Indenture or in any Special Warrant Certificate or as to whether any shares will when issued be duly authorized or be validly issued and fully paid and non-assessable. The duty and responsibility as to all the matters and things
referred to in this Section 8.17 rests upon the Company and not upon the Special Warrant Agent and the failure of the Company to discharge any such duty and responsibility does not in any way render the Special Warrant Agent liable or place
upon it any duty or responsibility for breach of which it would be liable. 

  
 35 

	8.18	 Acceptance of Trusts 

The Special Warrant Agent hereby accepts the trusts of this Indenture and agrees to perform the same upon the terms and
conditions herein set forth or referred to unless and until discharged therefrom by resignation or in some other lawful way. 
  

	8.19	 Special Warrant Agent’s Authority to Carry on Business 

The Special Warrant Agent represents to the Company that at the date hereof it is authorized to carry on the business of a
trust company in British Columbia. If, notwithstanding the provisions of this Section 8.19, it ceases to be authorized to carry on such business in British Columbia, the validity and enforceability of this Indenture and of the Special Warrants
issued hereunder are not affected in any manner whatsoever by reason only of such event, provided that the Special Warrant Agent shall, within 30 calendar days after ceasing to be authorized to carry on such business in British Columbia,
either become so authorized or resign in the manner and with the effect specified in Section 8.5. 
  

	8.20	 Indemnification of Special Warrant Agent 

Without limiting any protection or indemnity of the Special Warrant Agent under any other provision hereof, or otherwise at
law, the Company hereby agrees to indemnify and hold harmless the Special Warrant Agent from and against any and all liabilities, losses, damages, penalties, claims, actions, suits, costs, expenses and disbursements, including reasonable legal or
advisor fees and disbursements, of whatever kind and nature which may at any time be imposed on, incurred by or asserted against the Special Warrant Agent in connection with the performance of its duties and obligations hereunder, other than such
liabilities, losses, damages, penalties, claims, actions, suits, costs, expenses and other disbursements arising by reason of the gross negligence or fraud of the Special Warrant Agent. This provision shall survive the resignation or removal of the
Special Warrant Agent, or the termination of this Indenture. The Special Warrant Agent shall not be under any obligation to prosecute or to defend any action or suit in respect of the relationship which, in the opinion of its counsel, may involve it
in expense or liability, unless the Company shall, so often as required, furnish the Special Warrant Agent with satisfactory indemnity and funding against such expense or liability. 

Notwithstanding any other provision of this Indenture, and whether such losses or damages are foreseeable or unforeseeable, the Special
Warrant Agent shall not be liable under any circumstances whatsoever for any (a) breach by any other party of securities law or any other rule of any securities regulatory authority, (b) lost profits or (c) special, indirect,
incidental, consequential, exemplary, aggravated or punitive losses or damages. 
  

	8.21	 Performance of Covenants by Special Warrant Agent 

If the Company fails to perform any of its covenants contained in this Indenture, then the Company will notify the Special
Warrant Agent in writing of such failure and upon receipt by the Special Warrant Agent of such notice, the Special Warrant Agent will notify the Special Warrantholders of such failure on the part of the Company and may itself perform any of the said
covenants capable of being performed by it, but shall be under no obligation to perform said covenants or to notify the Special Warrantholders of such performance by it. All sums expended or disbursed by the Special Warrant Agent in so doing shall
be reimbursed as provided in Section 3.9. No such performance, expenditure or disbursement by the Special Warrant Agent shall be deemed to relieve the Company of any default hereunder or of its continuing obligations under the covenants herein
contained. 
  

	8.22	 Third Party Interests 

Each party to this Indenture hereby represents to the Special Warrant Agent that any account to be opened by, or interest to
held by the Special Warrant Agent in connection with this Indenture, for or to the credit of such party, either (i) is not intended to be used by or on behalf of any third party; or (ii) is intended to be used by or on behalf of a third
party, in which case such party hereto agrees to complete and execute forthwith a declaration in the Special Warrant Agent’s prescribed form as to the particulars of such third party. 

  
 36 

	8.23	 Not Bound to Act 

The Special Warrant Agent shall retain the right not to act and shall not be liable for refusing to act if, due to a lack of
information or for any other reason whatsoever, the Special Warrant Agent, in its sole reasonable judgment, determines that such act might cause it to be in non-compliance with any applicable anti-money laundering or anti-terrorist legislation,
regulation or guideline. Further, should the Special Warrant Agent, in its sole reasonable judgment, determine at any time that its acting under this Indenture has resulted in its being in non-compliance with any applicable anti-money laundering or
anti-terrorist legislation, regulation or guideline, then it shall have the right to resign on 10 calendar days’ written notice to the Company, provided (i) that the Special Warrant Agent’s written notice shall describe the
circumstances of such non-compliance; and (ii) that if such circumstances are rectified to the Special Warrant Agent’s satisfaction within such 10 calendar day period, then such resignation shall not be effective. 

 

	9.	 NOTICES 

  

	9.1	 Notice to Company, Special Warrant Agent and Agent 

Any notice to the Company, Special Warrant Agent or the Agent under the provisions of this Indenture is valid and effective if
in writing delivered, sent by registered letter, postage prepaid or if to the Company or Agent sent by facsimile or if to the Special Warrant Agent by email: 
  

					
	 (a)         to the Company at:

			
	 ESSA Pharma Inc.
		 Attention:
		 Bob Rieder

	 999 West Broadway, Suite 720
		 Facsimile:
		 (888) 308-8974

	 Vancouver, BC V5Z 1K5
				
	
	  with a copy to, which shall not constitute notice:

			
	 Blake Cassels & Graydon LLP
		 Attention:
		 Joseph Garcia

	 Suite 2600, 595 Burrard Street
		 Facsimile:
		 (604) 631-3309

	 Vancouver, BC V7X 1L3
				
	
	 (b)         to the Special Warrant Agent at:

			
	 Computershare Trust Company of Canada

3rd Floor, 510 Burrard Street

Vancouver, BC V6C 3B9
		 Attention:
		 General Manager, Corporate Trust

		  
 Email:
		  
 corporatetrust.vancouver@computershare.com

				
	
	 (c)         to the Agent at:

			
	 Bloom Burton & Co. Limited
		 Attention:
		 Jolyon Burton

	 65 Front Street East, Suite 300
		 Email:
		 jburton@bloomburton.com

	 Toronto, ON M5E 1B5
				
	
	  with a copy to, which shall not constitute notice:

			
	 Baker & McKenzie LLP
		 Attention:
		 Sonia Yung

	 Brookfield Place
		 Facsimile:
		 (416) 863-6275

	 181 Bay Street, Suite 2100
				
	 Toronto, ON M5J 2T3
				

  
 37 

 Any notice, direction or other instrument aforesaid will, if delivered, be deemed
to have been given and received on the calendar day it was delivered and, if mailed, be deemed to have been received on the fifth Business Day following the date of the postmark on such notice and, if sent by facsimile, be deemed to have been given
and received on the calendar day it was so sent unless it was sent: 
  

	 	(a)	 on a calendar day which is not a business day in the place to which it was sent; or 

 

	 	(b)	 after 4:30 p.m. in the place to which it was sent, 

in which cases it will be deemed to have been given and received on the next calendar day which is a business day in the place to which it was
sent. 
  

	9.2	 Notice to Special Warrantholders 

Any notice to the Special Warrantholders under the provisions of this Indenture is valid and effective if delivered, sent by
regular mail or sent by courier, to each Special Warrantholder at its address appearing on the register of Special Warrants kept by the Special Warrant Agent or, in the case of joint holders, to the first such address, and, if delivered or
couriered, shall be deemed to have been given and received on the calendar day it was delivered and, if mailed, be deemed to have been received on the fifth Business Day following the date of the postmark on such notice. 

A copy of any notice provided to the Special Warrantholders shall be concurrently provided to the Agent in the manner
specified in Section 9.1. 
  

	10.	 POWER OF BOARD OF DIRECTORS 

  

	10.1	 Board of Directors 

In this Indenture, where the Company is required or empowered to exercise any acts, all such acts may be exercised by the
directors of the Company, by any duly appointed committee of the directors of the Company or by those officers of the Company authorized to exercise such acts. 
  

	11.	 MISCELLANEOUS PROVISIONS 

  

	11.1	 Further Assurances 

The parties covenant and agree from time to time, as may be reasonably required by any party hereto, to execute and deliver
such further and other documents and do all matters and things which are convenient or necessary to carry out the intention of this Indenture more effectively and completely. 
  

	11.2	 Unenforceable Terms 

If any term, covenant or condition of this Indenture or the application thereof to any party or circumstance is invalid or
unenforceable to any extent, the remainder of this Indenture or application of such term, covenant or condition to a party or circumstance other than those to which it is held invalid or unenforceable is not affected thereby and each remaining term,
covenant or condition of this Indenture is valid and enforceable to the fullest extent permitted by law. 
  

	11.3	 No Waiver 

No consent or waiver, express or implied, by either party to or of any breach or default by the other party in the performance
by the other party of its obligations hereunder is deemed or construed to be a consent or waiver to or of any other breach or default in the performance of obligations hereunder by such party. Failure on the part of either party to complain of any
act or failure to act of the other party or to declare the other party in default, irrespective of how long such failure continues, does not constitute a waiver by such party of its rights hereunder. 

  
 38 

	11.4	 Waiver by Special Warrantholders and Special Warrant Agent 

Notwithstanding Section 11.3 above, upon the happening of any default hereunder: 

 

	 	(a)	 the holders of not less than 66 and 2/3% of the Special Warrants plus one Special Warrant then outstanding shall have power (in addition to the
powers exercisable by extraordinary resolution) by requisition in writing to instruct the Special Warrant Agent to waive any default hereunder and the Special Warrant Agent shall thereupon waive the default upon such terms and conditions as shall be
prescribed in such requisition; or 

  

	 	(b)	 the Special Warrant Agent shall have power to waive any default by the Company hereunder upon such terms and conditions as the Special Warrant
Agent may deem advisable, if, in the Special Warrant Agent’s opinion, relying on the opinion of legal counsel, the same shall have been cured or adequate provision made therefor; 

provided that no delay or omission of the Special Warrant Agent or of the Special Warrantholders to exercise any right or power
accruing upon any default shall impair any such right or power or shall be construed to be a waiver of any such default or acquiescence therein and provided further that no act or omission either of the Special Warrant Agent or of the Special
Warrantholders shall extend to or be taken in any manner whatsoever to affect any subsequent default hereunder of the rights resulting therefrom. 
  

	11.5	 Suits by Special Warrantholders 

  

	 	(a)	 No Special Warrantholder has any right to institute any action, suit or proceeding at law or in equity for the purpose of enforcing the execution
of any trust or power hereunder or for the appointment of a liquidator or receiver or for a receiving order under the Bankruptcy and Insolvency Act (Canada) or to have the Company wound up or to file or prove a claim in any liquidation or
bankruptcy proceedings or for any other remedy hereunder unless the Special Warrantholders by Extraordinary Resolution have made a request to the Special Warrant Agent and the Special Warrant Agent has been afforded reasonable opportunity to proceed
or complete any action or suit for any such purpose whether or not in its own name and the Special Warrantholders, or any of them, have furnished to the Special Warrant Agent, when so requested by the Special Warrant Agent sufficient funds and
security and indemnity satisfactory to it against the costs, expenses and liabilities to be incurred therein or thereby and the Special Warrant Agent has failed to act within a reasonable time or the Special Warrant Agent has failed to actively
pursue any such act or proceeding. 

  

	 	(b)	 Subject to the provisions of this Section and otherwise in this Indenture, all or any of the rights conferred upon a Special Warrantholder by the
terms of a Special Warrant may be enforced by such Special Warrantholder by appropriate legal proceedings without prejudice to the right which is hereby conferred upon the Special Warrant Agent to proceed in its own name to enforce each and all of
the provisions herein contained for the benefit of the Special Warrantholders from time to time. 

  

	11.6	 SEC Reporting Status 

The Company confirms that as at the date of execution of this Indenture it does not have a class of securities registered
pursuant to Section 12 of the 1934 Act, and is not subject to a reporting obligation pursuant to Section 15(d) of the 1934 Act. 

The Company covenants that in the event that (i) any class of its securities shall become registered pursuant to
Section 12 of the 1934 Act or the Company shall incur a reporting obligation pursuant to Section 15(d) of the 1934 Act, or (ii) any such registration or reporting obligation shall be terminated by the Company in accordance with the
1934 Act, the Company shall promptly deliver to the Special Warrant Agent an Officer’s Certificate (in a form provided by the Special Warrant Agent) notifying the Special Warrant Agent of such registration or termination and such other
information as the Special Warrant Agent may require at the time. The Company acknowledges that the Special Warrant Agent is relying upon the foregoing representation and covenants in order to meet certain SEC obligations with respect to those
clients who are filing with the SEC. 

  
 39 

	11.7	 Force Majeure 

Except for the payment obligations of the Company contained herein, neither party shall be liable to the other, or held in
breach of this Indenture, if prevented, hindered, or delayed in the performance or observance of any provision contained herein by reason of act of God, riots, terrorism, acts of war, epidemics, governmental action or judicial order, earthquakes, or
any other similar causes (including, but not limited to, mechanical, electronic or communication interruptions, disruptions or failures). Performance times under this Indenture shall be extended for a period of time equivalent to the time lost
because of any delay that is excusable under this Section. 
  

	11.8	 Privacy Matters 

The Company acknowledges that the Special Warrant Agent may, in the course of providing services hereunder, collect or receive
financial and other personal information about such parties and/or their representatives, as individuals, or about other individuals related to the subject matter hereof, and use such information for the following purposes: 

 

	 	(a)	 to provide the services required under this Indenture and other services that may be requested from time to time; 

 

	 	(b)	 to help the Special Warrant Agent manage its servicing relationships with such individuals; 

 

	 	(c)	 to meet the Special Warrant Agent’s legal and regulatory requirements; and 

 

	 	(d)	 if Social Insurance Numbers are collected by the Special Warrant Agent, to perform tax reporting and to assist in verification of an
individual’s identity for security purposes. 

 The Company acknowledges and agrees that the Special Warrant Agent
may receive, collect, use and disclose personal information provided to it or acquired by it in the course of its acting as agent hereunder for the purposes described above and, generally, in the manner and on the terms described in its Privacy
Code, which the Special Warrant Agent shall make available on its website or upon request, including revisions thereto. Some of this personal information may be transferred to servicers in the United States for data processing and/or storage.
Further, the Company agrees that it shall not provide or cause to be provided to the Special Warrant Agent any personal information relating to an individual who is not a party to this Indenture unless the Company has assured itself that such
individual understands and has consented to the aforementioned uses and disclosures. 
  

	11.9	 Enurement 

This Indenture enures to the benefit of and is binding upon the parties hereto and their respective successors and assigns.

  
 40 

	11.10	 Formal Date and Effective Date 

For the purpose of convenience this Indenture is referred to as bearing the formal date of January 16, 2015, however
notwithstanding such formal date, this Indenture becomes effective as between the Company and any particular Special Warrantholder upon the date of issuance of a Special Warrant Certificate to such Special Warrantholder. 

 

			
	 ESSA PHARMA INC.

		
	 Per:
		
			 (signed) “David Wood”

			 Authorized Signatory

	
	COMPUTERSHARE TRUST COMPANY OF CANADA
		
	 Per:
		
			 (signed) “Jill Dunn”

			 Authorized Signatory

		
	 Per:
		
			 (signed) “Clara Yiu”

			 Authorized Signatory

 Signature Page to Special Warrant Indenture 

 SCHEDULE “A” 

FORM OF SPECIAL WARRANT CERTIFICATE 

“THE SECURITIES REPRESENTED HEREBY AND THE SECURITIES ISSUABLE UPON EXERCISE HEREOF HAVE NOT BEEN AND WILL NOT BE REGISTERED UNDER THE
UNITED STATES SECURITIES ACT OF 1933, AS AMENDED (THE “U.S. SECURITIES ACT”) OR ANY STATE SECURITIES LAWS, AND MAY BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED ONLY (A) TO THE CORPORATION (B) OUTSIDE THE UNITED STATES IN
COMPLIANCE WITH RULE 904 OF REGULATION S UNDER THE U.S. SECURITIES ACT AND IN COMPLIANCE WITH LOCAL LAWS AND REGULATIONS, (C) PURSUANT TO A REGISTRATION STATEMENT THAT HAS BEEN DECLARED EFFECTIVE UNDER THE U.S. SECURITIES ACT AND IS AVAILABLE
FOR RESALE OF THE SECURITIES, OR (D) IN COMPLIANCE WITH AN EXEMPTION FROM REGISTRATION UNDER THE U.S. SECURITIES ACT, INCLUDING RULE 144 OR RULE 144A THEREUNDER, IF AVAILABLE, AND, IN EACH CASE, IN COMPLIANCE WITH ANY APPLICABLE STATE
SECURITIES LAWS. THE HOLDER FURTHER UNDERSTANDS AND AGREES THAT IN THE EVENT OF A TRANSFER PURSUANT TO THE FOREGOING CLAUSE (B) OR (D), THE CORPORATION WILL REQUIRE A LEGAL OPINION OF COUNSEL OF RECOGNIZED STANDING OR OTHER EVIDENCE REASONABLY
SATISFACTORY TO THE CORPORATION THAT SUCH TRANSFER IS EXEMPT FROM REGISTRATION UNDER THE U.S. SECURITIES ACT AND APPLICABLE STATE SECURITIES LAWS. DELIVERY OF THIS CERTIFICATE MAY NOT CONSTITUTE “GOOD DELIVERY” IN SETTLEMENT OF
TRANSACTIONS ON STOCK EXCHANGES IN CANADA.” 
 [Note: The legend above need only be endorsed on the special warrant certificate
issued to or for the account or benefit of a person in the United States] 
 “UNLESS PERMITTED UNDER SECURITIES LEGISLATION, THE
HOLDER OF THIS SECURITY MUST NOT TRADE THE SECURITY BEFORE THE DATE THAT IS 4 MONTHS AND A DAY AFTER JANUARY 16, 2015.” 

“THE SPECIAL WARRANTS REPRESENTED BY THIS CERTIFICATE WILL BE DEEMED TO BE EXERCISED AT THE DEEMED EXERCISE TIME (AS DEFINED BELOW)
AND WILL BE VOID THEREAFTER.” 
 SPECIAL WARRANT CERTIFICATE 

ESSA PHARMA INC. 

(incorporated under the laws of British Columbia) 
  

			
	 No. SW-«Warrant»
		 «Number» SPECIAL WARRANTS entitling the holder to acquire one Warrant Share for each Special Warrant, subject to adjustment as set out
below

 THIS IS TO CERTIFY that, for value received, «Name» (the “Special
Warrantholder”) is the registered holder of the number of special warrants (the “Special Warrants”) stated above and is entitled to acquire in the manner and at the time, and subject to the restrictions contained in the
Indenture (as defined below) hereinafter referred to, the number of Common Shares (the “Warrant Shares”) of ESSA Pharma Inc. (the “Company”) as is equal to the number of Special Warrants represented hereby (subject
to adjustment as set out in the Indenture (as defined below)), all without payment of any consideration in addition to that paid for the Special Warrants represented hereby. 

  
 A-1 

 The Special Warrants represented by this certificate are issued under and
pursuant to a certain indenture (the “Indenture”) made as of January 16, 2015 between the Company and Computershare Trust Company of Canada (the “Special Warrant Agent”) (which expression includes any successor
trustee appointed under the Indenture), to which Indenture and any instruments supplemental thereto reference is hereby made for a full description of the rights of the holders of the Special Warrants and the terms and conditions upon which such
Special Warrants are, or are to be, issued and held, all to the same effect as if the provisions of the Indenture and all instruments supplemental thereto were herein set forth, to all of which provisions the holder of these Special Warrants by
acceptance hereof assents. All terms defined in the Indenture are used herein as so defined. In the event of any conflict or inconsistency between the provisions of the Indenture and the provisions of this Special Warrant Certificate, except those
that are necessary by context, the provisions of the Indenture shall prevail. The Company will furnish to the holder of this Special Warrant Certificate, upon request and without charge, a copy of the Indenture. 

A Special Warrantholder may, at any time before 4:00 p.m. (Vancouver time) (the “Deemed Exercise Time”) on
the first Business Day (the “Deemed Exercise Date”) after the earlier of: 
  

	 	(i)	 October 16, 2015 (the “Deadline Date”); and 

 

	 	(ii)	 the date on which the Common Shares first begin to trade on either (x) one of the Nasdaq Global Select Market, the Nasdaq Global Market or the
Nasdaq Capital Market market tiers of the NASDAQ Stock Market LLC (a U.S. national securities exchange), or (y) the NYSE MKT LLC (a U.S. national securities exchange) (the “U.S. Listing Date”), 

exercise all or any number of the Special Warrants outstanding which are then held by the Special Warrantholder. 

If any Special Warrants have not been voluntarily exercised by the holders thereof prior to the Deemed Exercise Time, then
such Special Warrants will be deemed to have been exercised, delivered and surrendered by the holder thereof at the Deemed Exercise Time without any further action on the part of the holder. 

The holder of this Special Warrant Certificate may, at any time before the Deemed Exercise Time, exercise all or any number
of the Special Warrants represented hereby, by surrendering to the Special Warrant Agent a Special Warrant Certificate or Special Warrant Certificates representing the number of Special Warrants to be exercised, together with the duly completed and
executed exercise form attached as Appendix 1 hereto in accordance with the instructions contained in Appendix 4 attached hereto. Any such exercise at a time prior to 4 months and one calendar day after the Closing Date is subject to
compliance with, and may be restricted by, Applicable Legislation. If, at the time of the exercise of the Special Warrants, there remain restrictions on resale under Applicable Legislation on the Warrant Shares acquired, the Company may endorse the
certificates representing the Warrant Shares acquired with respect to such resale restrictions. 
 The Warrant Shares in
respect of which the Special Warrants are exercised will be deemed to have been issued on the date of such exercise, at which time each Special Warrantholder will be deemed to have become the holder of record of such Warrant Shares. 

After the exercise or deemed exercise of Special Warrants, the Special Warrant Agent shall within three Business Days of such
exercise or deemed exercise cause to be delivered to each Special Warrantholder at its address specified in the register for the Special Warrants maintained by the Special Warrant Agent, certificates for the appropriate number of Warrant Shares
issuable in respect of such Special Warrants, not exceeding those which such Special Warrantholder is entitled to acquire pursuant to the Special Warrants so exercised. If the holder of this Special Warrant Certificate exercises some but not all of
the Special Warrants represented hereby, he or she will be entitled to receive, without charge, a new Special Warrant Certificate representing the unexercised number of the Special Warrants represented hereby. 

The holder of this Special Warrant Certificate may at any time up to the Deemed Exercise Time, upon written instruction
delivered to the Special Warrant Agent and payment of the charges provided for in the Indenture and otherwise in accordance with the provisions of the Indenture, exchange this Special Warrant Certificate for other Special Warrant Certificates
evidencing Special Warrants entitling the holder to acquire in the aggregate the same number of Warrant Shares as may be acquired under this Special Warrant Certificate. 

  
 A-2 

 The number of Warrant Shares which may be acquired by a Special Warrantholder
upon exercise of Special Warrants, are also subject to and governed by Article 4 of the Indenture with respect to anti-dilution provisions, including provisions for the appropriate adjustment of the class, number and price of the securities issuable
hereunder upon the occurrence of certain events including any subdivision, consolidation, or reclassification of the shares, payment of stock dividends, or amalgamation of the Company. In addition, should the U.S. Listing Date not occur on or prior
to the Deadline Date, then following the Deadline Date (including, for the avoidance of doubt, the Deemed Exercise Time), as to each Warrant Share underlying each Special Warrant immediately prior to the Deadline Date, such Special Warrant shall
entitle the holder thereof to obtain 1.5 Warrant Shares upon exercise or deemed exercise thereof in accordance with Article 4.2 of the Indenture. The foregoing adjustment shall be in addition to any adjustment provided for in Section 4.1 of the
Indenture and shall be applied after giving effect to the adjustments provided for in Section 4.1 of the Indenture. 

The holding of the Special Warrants evidenced by this Special Warrant Certificate does not constitute the Special
Warrantholder a shareholder of the Company or entitle such holder to any right or interest in respect thereof except as herein and in the Indenture expressly provided. 

The Special Warrants may only be transferred by the Special Warrantholder (or its legal representatives or its attorney duly
appointed), in accordance with applicable laws and upon compliance with the conditions set out in the Indenture, on the register kept at the office of the Special Warrant Agent by delivering to the Special Warrant Agent’s Vancouver office a
duly executed Form of Transfer attached as Appendix 2 hereto and complying with such other reasonable requirements as the Company and the Special Warrant Agent may prescribe and such transfer shall be duly noted on the register by the Special
Warrant Agent. 
 The holder understands and acknowledges that the Special Warrants and the Warrant Shares issuable
hereunder (together, the “Securities”) have not been and will not be registered under the United States Securities Act of 1933, as amended (the “1933 Act”), or under the securities laws of any state of the United
States, and that Special Warrants originally issued in the United States or to, or for the account or benefit of, a person in the United States are, and any Securities issued upon exercise of such Special Warrants will be, “restricted
securities” within the meaning of Rule 144(a)(3) of the 1933 Act. 
 The holder understands that, until such time as
the same is no longer required under applicable requirements of the 1933 Act or applicable state securities laws, certificates representing Securities which are “restricted securities”, and all certificates issued in exchange therefor or
in substitution thereof, will bear a U.S. restrictive legend substantially in the form prescribed by Section 5.9 of the Special Warrant Indenture; provided that if the Special Warrants or the Warrant Shares are being sold outside the
United States in compliance with the requirements of Rule 904 of Regulation S (“Regulation S”) under the 1933 Act. at a time when the Company is a “foreign issuer”, as defined in Regulation S at the time of sale, such
legend may be removed by providing an executed declaration to the Special Warrant Agent or, with respect to Warrant Shares, the Company’s registrar and transfer agent, in substantially the form set forth as Appendix 3 attached to this Special
Warrant Certificate (or in such other form as the Company acting reasonably may prescribe from time to time) along with such additional information as the Company, the Special Warrant Agent or the transfer agent (as the case may be) may require,
and, if requested by the Company, the Special Warrant Agent or the transfer agent (as the case may be), an opinion of counsel of recognized standing in form and substance satisfactory to the Company, the Special Warrant Agent and the transfer agent
(as applicable) to the effect that such sale is being made in compliance with Rule 904 of Regulation S; and provided further that if any Securities are being sold in accordance with Rule 144 under the 1933 Act or are eligible to be sold by
the holder thereof pursuant to Rule 144 under the U.S. Securities Act without restriction thereunder, the legend may be removed by delivery to the Company and the transfer agent of an opinion of counsel of recognized standing in form and substance
reasonably satisfactory to the Company, the Special Warrant Agent and the transfer agent (as applicable), to the effect that such legend is no longer required under applicable requirements of the 1933 Act and applicable state securities laws. 

This Special Warrant Certificate shall be construed in accordance with the laws of the Province of British Columbia and the
laws of Canada applicable therein and shall be treated in all respects as a British Columbia contract. 

  
 A-3 

 After the exercise or deemed exercise of any of the Special Warrants represented
by this Special Warrant Certificate, the Special Warrantholder shall no longer have any rights under either the Indenture or this Special Warrant Certificate with respect to such Special Warrants, other than the right to receive certificates
representing the Warrant Shares issuable on the exercise of those Special Warrants, and those Special Warrants shall be void and of no further value or effect. 

The Indenture contains provisions making binding upon all Special Warrantholders resolutions passed at meetings of such
holders in accordance with such provisions or by instruments in writing signed by the Special Warrantholders holding a specified percentage of the Special Warrants. 

  
 A-4 

 IN WITNESS WHEREOF the Company has caused this Special Warrant Certificate to be
executed and the Special Warrant Agent has caused this Special Warrant Certificate to be countersigned by its duly authorized officers as of this      day of
            , 201    . 
  

			
	 ESSA PHARMA INC.

		
	 Per:
		
			  

			 Authorized Signatory

	
	 COUNTERSIGNED BY:

	
	COMPUTERSHARE TRUST COMPANY OF CANADA
		
	 Per:
		
			  

			 Authorized Signatory

 Signature Page to Special Warrant Certificate 

 APPENDIX 1 TO 

SPECIAL WARRANT CERTIFICATE 

EXERCISE FORM 
  

	TO:	 ESSA PHARMA INC. (the “Company”) 

1. The undersigned hereby irrevocably exercises the right to acquire
                 Common Shares of the Company (or such number of other securities or property to which such Special Warrants entitle the undersigned in lieu thereof or
in addition thereto under the provisions of the accompanying Special Warrant Certificate) according to the provisions of the Indenture referenced in the accompanying Special Warrant Certificate. 

2. The Common Shares are to be registered as follows: 
  

			
	Name:		  

	 (print clearly)

			
		
	Address in full:		  

			
		
	Number of Common Shares:		  

 3. Such securities should be sent by courier to: 

 

			
	Name:		  

	 (print clearly)

			
		
	Address in full:		  

 If the number of Special Warrants exercised is less than the number of Special Warrants represented hereby,
the undersigned requests that the new Special Warrant Certificate representing the balance of the Special Warrants be registered in the name of the undersigned and should be sent by courier to: 

 

			
	Name:		  

			
	 (print clearly)

		
	Address in full:		  

 4. The undersigned understands that upon the exercise of Special Warrants issued in the United States or to,
or for the account or benefit of, a person in the United States, which bear the legend in Section 5.9(a) of the Special Warrant Indenture, the certificate(s) representing the Common Shares will bear a legend substantially in the form prescribed
by Section 5.9(a) of the Special Warrant Indenture restricting transfer of the Common Shares without registration under the United States Securities Act of 1933, as the same has been, and hereafter from time to time, may be amended (the
“U.S. Securities Act”) and applicable state securities laws unless an exemption from registration is available (including when the conditions for legend removal set forth in Section 5.9(a) have been satisfied). 

  
 A1-1 

 DATED at
                    ,                     , this
     day of             , 20    . 
  

					
	  
				  

	 Signature Witnessed or Guaranteed

(See instructions to Special Warrantholders in Appendix 4)
				 (Signature of Special Warrantholder, to be the same as appears on the face of this Special Warrant Certificate)

			
	 Name of Special Warrantholder:
				
			
					  

			
	 Address (Please print) :
				  

			
					  

 Notes to Special Warrantholders: 

 

	(1)	 In order to voluntarily exercise the Special Warrants represented by this certificate, prior to the Deemed Exercise Time pursuant to
Section 5.2 of the Indenture, this exercise form must be delivered to the Special Warrant Agent, together with this Special Warrant Certificate. Refer to the instructions to Special Warrantholders attached as Appendix 4 to this Special Warrant
Certificate. 

  

	(2)	 If this exercise form indicates that the Common Shares are to be issued to a person or persons other than the registered holder of this Special
Warrant Certificate, the signature of such holder on the exercise form must be guaranteed by a Canadian Schedule 1 chartered bank, a major trust company in Canada, a member of the Securities Transfer Association Medallion Program (STAMP), a member
of the Stock Exchange Medallion Program (SEMP) or a member of the New York Stock Exchange Inc. Medallion Signature Program (MSP). 

  
 A1-2 

 APPENDIX 2 TO 

SPECIAL WARRANT CERTIFICATE 

FORM OF TRANSFER 
  

	TO:	 ESSA PHARMA INC. (the “Company”) 

FOR VALUE RECEIVED, the undersigned hereby sells, assigns and transfers unto (name)
                     (the “Transferee”), of
                     (residential address)
                     Special Warrants of ESSA Pharma Inc. registered in the name of the undersigned on the records of Computershare Trust Company of
Canada represented by the attached certificate, and irrevocably appoints                      as the attorney of the undersigned to transfer the said
securities on the books or register of transfer, with full power of substitution. 
 DATED the      day of
            , 20    . 
  

					
	  
				  

	 Signature Guaranteed

(See instructions to Special

Warrantholders in Appendix 4)
				 (Signature of Special Warrantholder, to be the same as appears on the face of this Special Warrant Certificate)

			
	 Name of Special Warrantholder:

Address (Please Print):
				  

			
					  

			
					  

 REASON FOR TRANSFER – For US Residents only (where the individual(s) or corporation receiving the
securities is a US resident). Please select only one (see instructions below). 
  

							
	  ̈ Gift
		  ̈ Estate
		  ̈ Private Sale
		  ̈ Other (or no change in ownership)

 Date of Event (Date of gift, death or sale): Value per Warrant on the date of event: 

 

									
	 

		 ̈				 ̈		
		 CAD
		 OR
		 USD
		

  
 A2-1 

 Note to Special Warrantholders: 

 

	(1)	 In order to transfer the Special Warrants represented by this Special Warrant Certificate, this transfer form must be delivered to the Special
Warrant Agent, together with this Special Warrant Certificate. 

  

	(2)	 The signature of the holder on the transfer form must be guaranteed by a Canadian Schedule 1 chartered bank, a major trust company in Canada, a
member of the Securities Transfer Association Medallion Program (STAMP), a member of the Stock Exchange Medallion Program (SEMP) or a member of the New York Stock Exchange Inc. Medallion Signature Program (MSP). 

REASON FOR TRANSFER – FOR US RESIDENTS ONLY: 

Consistent with the regulations of the United States Internal Revenue Service (IRS), the Special Warrant Agent is required to request cost
basis information from securityholders resident in the United States. Please indicate the reason for requesting the transfer as well as the date of event relating to the reason. The event date is not the day in which the transfer is finalized, but
rather the date of the event which led to the transfer request (i.e. date of gift, date of death of the securityholder, or the date the private sale took place). 

  
 A2-2 

 APPENDIX 3 

FORM OF DECLARATION FOR REMOVAL OF LEGEND 
  

			
	 TO:
		 ESSA Pharma Inc.

		
	 AND TO:
		 The registrar and transfer agent for the securities of ESSA Pharma Inc.; OR

Computershare Trust Company of Canada, as Special Warrant Agent for the Special Warrants of ESSA Pharma Inc.

 The undersigned (A) acknowledges that the sale of the securities of ESSA Pharma Inc. (the
“Company”) represented by certificate number                     , to which this declaration relates was made in reliance on
Rule 904 of Regulation S under the United States Securities Act of 1933, as the same has been, and hereafter from time to time, may be amended (the “U.S. Securities Act”) and (B) certifies that (1) the
undersigned is not an “affiliate” of the Company as that term is defined in Rule 405 under the U.S. Securities Act, a “distributor” or an affiliate of “distributor”, (2) the offer of such securities was not
made to a person in the United States and either (a) at the time the buy order was originated, the buyer was outside the United States, or the seller and any person acting on its behalf reasonably believed that the buyer was outside the United
States or (b) the transaction was executed on or through the facilities of a “designated offshore securities market” (as defined in Rule 902 of Regulation S under the U.S. Securities Act) and neither the seller nor any person acting
on its behalf knows that the transaction has been prearranged with a buyer in the United States, (3) neither the seller nor any affiliate of the seller nor any person acting on their behalf has engaged or will engage in any “directed
selling efforts” in the United States in connection with the offer and sale of such securities, (4) the sale is bona fide and not for the purpose of “washing-off” the resale restrictions imposed because the securities are
“restricted securities” as that term is described in Rule 144(a)(3) under the U.S. Securities Act, (5) the seller does not intend to replace such securities sold in reliance on Rule 904 of the U.S. Securities Act with
fungible unrestricted securities, and (6) the contemplated sale is not a transaction, or part of a series of transactions, which, although in technical compliance with Regulation S under the U.S. Securities Act, is part of a plan or scheme to
evade the registration provisions of the U.S. Securities Act. Unless otherwise specified, terms set forth above in quotation marks have the meanings given to them by Regulation S under the U.S. Securities Act. 

DATED at                      this
     day of             , 20    . 
  

			
	 By:
		  

	 Name:
		
	 Title:
		

 A. AFFIRMATION BY SELLER’S BROKER-DEALER (REQUIRED FOR SALES IN ACCORDANCE WITH SECTION
(B)(2)(B) ABOVE) 
 We have read the foregoing representations of our customer,
                     (the “Seller”) dated
                    , with regard to our sale, for such Seller’s account, of the securities of the Company described therein, and on behalf of
ourselves we certify and affirm that (A) we have no knowledge that the transaction had been prearranged with a buyer in the United States, (B) the transaction was executed on or through the facilities of a “designated offshore
securities market” (as defined in Rule 902 of Regulation S under the U.S. Securities Act); (C) neither we, nor any person acting on our behalf, engaged in any directed selling efforts in connection with the offer and sale of such
securities, and (D) no selling concession, fee or other remuneration is being paid to us in connection with this offer and sale other than the usual and customary broker’s commission that would be received by a person executing such
transaction as agent. Terms used herein have the meanings given to them by Regulation S under the U.S. Securities Act. 
  

			
	  

	Name of Firm
		
	By:		  

			Authorized officer
		
	Date:		  

  
 A3-1 

 APPENDIX 4 

INSTRUCTIONS TO SPECIAL WARRANTHOLDERS 

TO EXERCISE: 
 If the Special
Warrantholder voluntarily exercises Special Warrants prior to the Deemed Exercise Time pursuant to Section 5.2 of the Indenture, it must complete, sign and deliver: 
  

	 	(b)	 the Exercise Form, attached as Appendix 1; and 

  

	 	(c)	 the Special Warrant Certificates, 

to the Special Warrant Agent indicating the number of Common Shares to be acquired. In such case, the signature of such registered holder on
the Exercise Form must be witnessed. 
 TO TRANSFER: 

If the Special Warrantholder wishes to transfer Special Warrants, then the Special Warrantholder must complete, sign and deliver (as
appropriate): 
  

	 	(d)	 the Transfer Form attached as Appendix 2; and 

  

	 	(e)	 the Special Warrant Certificates, 

to the Special Warrant Agent indicating the number of Special Warrants to be transferred. 

If the Special Warrant Certificate is transferred, the Special Warrantholder’s signature on the Transfer Form must be guaranteed by a
Canadian Schedule 1 chartered bank, a major trust company in Canada, a member of the Securities Transfer Association Medallion Program (STAMP), a member of the Stock Exchange Medallion Program (SEMP) or a member of the New York Stock Exchange Inc.
Medallion Signature Program (MSP). 
 For the protection of the holder, it would be prudent to use registered mail if forwarding by mail.

 GENERAL: 
 If the Transfer Form or
Exercise Form is signed by a trustee, executor, administrator, curator, guardian, attorney, officer of a corporation or any person acting in a fiduciary or representative capacity, the Special Warrant Certificate must also be accompanied by evidence
of authority to sign satisfactory to the Special Warrant Agent. 
 The name and address of the Special Warrant Agent is: 

Computershare Trust Company of Canada 

3rd Floor, 510 Burrard Street 

Vancouver, British Columbia 

V6C 3B9 

  
 A4-1EX-4.7

 Exhibit 4.7 

GREENPARK TWO 

BASIC LEASE INFORMATION 
  

							
	LEASE EXECUTION DATE:		 August 25, 2014

		
	TENANT:		 ESSA PHARMACEUTICALS CORP.

		
	ADDRESS OF TENANT:		 7505 South Main, Suite 250, Houston, TX 77030

				
	TENANT CONTACT:		 Paul Cossum
		 Telephone:
		 858-352-8684

		
	LANDLORD:		 GREENPARK II MEDICAL LLC

		
	ADDRESS OF LANDLORD:		 c/o Transwestern Property Company

1020 Holcombe, Suite 1311

Houston, Texas 77030

			
	CONTACT:		 Property Manager
		 Telephone: (713) 795-0962

		
	PREMISES:		 Suite No. 250 in the office building (the “Building”) located on the land described as 7505 South Main, City of Houston, Harris
County, Texas and known as GREENPARK TWO MEDICAL PROFESSIONAL BUILDING, as more particularly described on Exhibit “A” (the “Land”; the Land together with the Building is the “Real Property”).
The Premises are outlined on the plan attached to the Lease as Exhibit “B” and are deemed to contain 2,577 rentable square feet. Landlord has made and makes no representations regarding the accuracy of such number.

		
	LEASE TERM:		 Sixty-three months, commencing September 1, 2014 (the “Commencement Date”) and ending at 5:00 p.m., November 30, 2019 (the
“Expiration Date”), subject to adjustment and earlier termination as provided in the Lease.

		
	BASE RENTAL:		 $6,657.25 per month, which is based on an annual Base Rental of $31.00 per rentable square foot per year, which Tenant agrees to pay to Landlord at
Greenpark II Medical LLC, P.O. Box 28, Laurel, NY 11948 (or at such other place as Landlord from time to time may designate in writing) in advance and without demand on the first day of each calendar month during and throughout the Lease
Term.

		
	BASE EXPENSE AMOUNT:		 The amount of Operating Expenses (including those Operating Expenses which Landlord elects to “gross-up” as provided in Paragraph 4(d) of
the Lease) for the Building during the calendar year 2014, as calculated by Landlord.

		
	PREPAID RENTAL:		 $6,657.25, representing payment of Base Rental for the first month of the Lease Term, to be paid on the date of execution of this
Lease.

		
	SECURITY DEPOSIT:		 $7,492.62 to be paid on the date of the execution of the Lease, and held by Landlord pursuant to the provisions of Paragraph 29 of the
Lease.

		
	SOLE PERMITTED USE:		 General Office

		
	TENANT’S PROPORTIONATE SHARE:		 3.218%, which is the percentage obtained by dividing (i) the rentable square feet in the Premises by (ii) the rentable square feet in the Building.
Landlord has advised Tenant, and Tenant has agreed, that solely for purposes of calculating Tenant’s Proportionate Share, the rentable area of the Premises is 2,577 square feet and the rentable area of the Building is 80,083 rentable square
feet. These numbers are not subject to remeasurement.

		
	 RIDER:
		 Collectively, Rider Nos. 100, 101, 102, and 106, which are attached hereto, contain additional provisions of this Lease and are hereby incorporated
in, and made a part of, this Lease.

  
 i 

 The foregoing Basic Lease Information is incorporated into and made a part of the Lease
identified above. If any conflict exists between any Basic Lease Information and the Lease, then the Basic Lease Information shall control. 
  

											
	LANDLORD:				TENANT:
			
	 GREENPARK II MEDICAL LLC,

a Delaware limited liability company
				 ESSA PHARMACEUTICALS, CORP.,

a Texas corporation

					
	 By:
		

				 By:
		

		 	  
	 		 		 	  

			 Norman Livingston
						 Name:
		 Bob Rieder

			 Managing Member
						 Title:
		 CEO

  
 ii 

 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
			
	1.	 	 Definitions and Basic Provisions
	  	 	1	  
	2.	 	 Lease of Premises
	  	 	2	  
	3.	 	 Services by Landlord
	  	 	2	  
	4.	 	 Additional Rent
	  	 	3	  
	5.	 	 Electricity
	  	 	4	  
	6.	 	 Payments and Performance
	  	 	5	  
	7.	 	 Tenant Plans and Specifications - Installation of Improvements
	  	 	5	  
	8.	 	 Completion of Improvements and Commencement of Rent
	  	 	5	  
	9.	 	 Relocation of Premises
	  	 	6	  
	10.	 	 Repairs and Reentry
	  	 	6	  
	11.	 	 Assignment and Subletting
	  	 	6	  
	12.	 	 Alterations and Additions by Tenant
	  	 	7	  
	13.	 	 Legal Use; Violations of Insurance Coverage; Nuisance
	  	 	7	  
	14.	 	 Laws and Regulations
	  	 	8	  
	15.	 	 Indemnity, Liability and Loss or Damage
	  	 	8	  
	16.	 	 Rules of the Building
	  	 	8	  
	17.	 	 Entry for Repairs and Inspection
	  	 	8	  
	18.	 	 Condemnation
	  	 	8	  
	19.	 	 Landlord’s Lien and Security Interest
	  	 	9	  
	20.	 	 Abandoned Property
	  	 	9	  
	21.	 	 Holding Over
	  	 	9	  
	22.	 	 Fire and Casualty
	  	 	10	  
	23.	 	 Entire Agreement and Amendment; No Representations or Warranties; No Memorandum of Lease
	  	 	11	  
	24.	 	 Transfer of Landlord’s Rights
	  	 	11	  
	25.	 	 Default
	  	 	11	  
	26.	 	 Waiver; Attorney’s Fees
	  	 	13	  
	27.	 	 Quiet Possession
	  	 	14	  
	28.	 	 Severability
	  	 	14	  
	29.	 	 Security Deposit
	  	 	14	  
	30.	 	 No Subrogation; Insurance
	  	 	14	  
	31.	 	 Binding Effect
	  	 	16	  
	32.	 	 Notices
	  	 	16	  
	33.	 	 Brokerage
	  	 	16	  
	34.	 	 Subordination
	  	 	16	  
	35.	 	 Joint and Several Liability
	  	 	16	  
	36.	 	 Building Name and Address
	  	 	16	  
	37.	 	 Estoppel Certificates; Financial Statements
	  	 	17	  
	38.	 	 Mechanic’s Liens
	  	 	17	  
	39.	 	 Taxes and Tenant’s Property
	  	 	17	  
	40.	 	 Constructive Eviction
	  	 	17	  
	41.	 	 Landlord’s Liability
	  	 	18	  
	42.	 	 Execution by Landlord
	  	 	18	  
	43.	 	 No Waiver
	  	 	18	  
	44.	 	 No Third Party Beneficiary
	  	 	18	  
	45.	 	 Number and Gender
	  	 	18	  
	46.	 	 Force Majeure
	  	 	18	  
	47.	 	 Environmental Compliance
	  	 	18	  
	48.	 	 APPLICABLE LAW; CONSENT TO JURISDICTION
	  	 	19	  

  

			
	 Exhibit “A”
	  	 Legal Description

	 Exhibit “B”
	  	 Floor Plan

  
 iii 

 Continued from Page ii 

 

			
	 Exhibit “C”
		 Holidays

	 Exhibit “D”
		 Leasehold Improvements Agreement

	 Exhibit “E”
		 Acceptance of Premises Memorandum

	 Exhibit “F”
		 Building Rules and Regulations

		
	 Rider No. 100
		 Lease Guaranty

	 Rider No. 101
		 Parking Facilities

	 Rider No. 102
		 Tenant’s Option to Renew

	 Rider No. 106
		 Schedule of Base Rental

  
 iv 

 LEASE AGREEMENT 

THIS LEASE AGREEMENT (the “Lease”) is made and entered into as of the      day of
August, 2014, by and between GREENPARK II MEDICAL LLC (“Landlord”) and ESSA PHARMACEUTICALS CORP., a Texas corporation (“Tenant”). 

1. Definitions and Basic Provisions. The definitions and basic provisions set forth in the Basic Lease
Information (the “Basic Lease Information”) executed by Landlord and Tenant contemporaneously herewith are incorporated herein by reference for all purposes. The additional terms defined below shall have the respective meanings
stated when used elsewhere in this Lease, and such terms and the following basic provisions constitute an integral part of this Lease: 

(a) “Additional Rent”: Any monies owed by tenant to Landlord under this Lease, including the
Operating Expense Payment, other than Base Rental. 
 (b) “Common Areas”: All common
facilities in or around the Building designed and intended for use by tenants in common with one another and Landlord (excluding any such facilities exclusively reserved, in whole or in part, to any specific tenant or occupant or Landlord’s
operation and management of the Building or the garage within the Building), including common hallways, corridors, elevators, elevator foyers, fire stairs, telephone and electrical closets, restrooms, mechanical rooms, janitor closets, vending areas
and other similar facilities for the use of all tenants. 
 (c) “Default Rate”: A floating
rate of interest equal to the lesser of (x) five percentage points above the then current “prime rate” announced by banks and other lending institutions, and (y) the maximum rate permitted by applicable Requirements. 

(d) “Legal Costs”: All reasonable out-of-pocket costs and expenses that a party incurs in any
legal proceeding pertaining to this Lease, in the exercise of a remedy under this Lease or regarding this Lease under applicable law, as the result of or under any bankruptcy event affecting the other party, or in connection with any other matter
for which this Lease entitles a party to reimbursement as “Legal Costs.” Legal Costs include reasonable attorneys’ fees, disbursements and other charges billed by a party’s attorneys, court costs and expenses, fees for bonds, and
reasonable charges for the services of paralegals, law clerks, process servers, private investigators, and all other personnel whose services are reasonably required and charged in connection with such party’s receipt of such legal services.

 (e) “Medical Waste”: All surgical, pathological, biological, infectious, or chemotherapy
waste; laboratory waste that has come in contact with pathogenic (disease-carrying) organisms; any human tissues, organs and/or other body parts removed during surgical operations of any nature, obstetrical procedures and autopsies, sharp
instruments, including, without limitation, needles, syringes and scalpel blades, or other medical instruments capable of causing punctures or cuts or coming into contact with any pathogenic organisms; and laboratory cultures and stocks of
infectious agents and any associated biological materials such as microbiological wastes; and any other materials defined as medical waste under the applicable law. 

(f) “Normal Business Hours”: From 8:00 a.m. until 6:00 p.m. on weekdays (except Holidays, as
defined on Exhibit “C” attached hereto and made a part hereof for all purposes), and from 8:00 a.m. until 1 p.m. on Saturdays (except Holidays). 

(g) “PHI”: or Protected Health Information, which is any information about health status,
provision of health care, or payment for health care that can be linked to a specific individual pursuant to US Health Insurance Portability and Accountability Act. 

(h) “Rental”: Includes Base Rental, the Operating Expense Payment, all Additional Rent and all
other sums this Lease requires Tenant to pay. 
 (i) “Requirements”: Present and future
laws, statutes, codes and executive orders, ordinances, orders, rules and regulations of any governmental authority now or hereafter created, and of any applicable fire rating bureau, or other body exercising similar functions, having jurisdiction
over the 

  
 1 

 
use, conditions or occupancy of the Premises, including those applicable to the performance of any Alterations, those that become applicable by reason of Alterations having been made, and those
applicable by reason of the nature or type of business Tenant operates in the Premises. 
 (j)
“Exhibits”: The following Exhibits are attached to and made a part of this Lease for all purposes: 
 A -
Land 
 B - Premises 

C - Holidays 

D - Leasehold Improvements Agreement 

E - Acceptance of Premises Memorandum 

F - Building Rules and Regulations 

2. Lease of Premises. In consideration of the obligation of Tenant to pay rent as herein provided and in
consideration of the other terms, covenants, and conditions hereof, Landlord hereby demises and leases to Tenant, and Tenant hereby leases and takes from Landlord, the Premises, together with the right to use in common with others the Common Areas,
for the Lease Term specified herein, all upon and subject to the terms and conditions set forth herein. This Lease and the obligations of Landlord hereunder are conditioned upon faithful performance by Tenant of all of the agreements and covenants
herein set out and agreed to by Tenant. Tenant agrees and acknowledges that there is excluded from Tenant’s use of the Premises (whether the Premises are or include one or more full floors within the Building) and Landlord hereby expressly
reserves for its sole and exclusive use, any and all mechanical, electrical, telephone and similar rooms, janitor closets, elevator, pipe and other vertical shafts and ducts, flues, stairwells, any area above the acoustical ceiling, and any other
areas not specifically shown on Exhibit “B” as being part of the Premises. 
 3. Services by
Landlord. Landlord agrees to furnish the following services to the Premises, as long as Tenant is not in default, at Landlord’s cost and expense but subject to recoupment through Operating Expenses, except as specifically provided to
the contrary elsewhere in this Lease: 
 (a) Hot and cold water (at the normal temperature of the supply of
water to the Building) for normal lavatory, water fountain and toilet purposes, all of such water service to be supplied from the regular supply of water to the Building at points of supply provided for general use of tenants of the Building through
fixtures installed by Landlord or by Tenant with Landlord’s consent; provided, however, nothing contained herein shall require Landlord to furnish hot water to any kitchen, bar or other such lavatory facility in the Premises. If Tenant
requires, uses or consumes water for any purpose in addition to ordinary drinking, cleaning, pantry or lavatory purposes with the existing plumbing fixtures within the Premises (“Additional Water”), then Landlord may install a water
meter, at Tenant’s sole cost and expense, and thereby measure Tenant’s Additional Water consumption beyond such uses. In such event: (1) Tenant shall pay for Additional Water consumed as measured by such meter and calculated by
Landlord, plus Landlord’s administrative charges for reading such meter; and (2) Tenant shall pay the sewer rent, charge or any other tax, rent, levy or charge that now or hereafter is assessed, imposed or shall become a lien upon the
Premises or the Real Property of which they are a part under any Requirement made or issued in connection with any such metered use. The bill rendered by Landlord for the above shall be payable by Tenant, as Additional Rent. 

(b) Heating, air conditioning and ventilation in season during Normal Business Hours, and at such temperature
and in such amounts as are considered by Landlord to be standard but, in any event, at temperatures and in amounts commensurate with those generally provided in Class “A” office buildings in the Medical Center submarket of Houston, Texas.
Such services at all other times shall be furnished only at the request of Tenant, who shall bear the actual cost thereof as reasonably determined by Landlord. Whenever machines or equipment that generate abnormal heat and affect the temperature
otherwise maintained by the air conditioning system are used in the Premises, Landlord shall have the right to install supplemental air conditioning units in the Premises, and the cost thereof, including the cost of installation, operation, use and
maintenance, shall be paid by Tenant to Landlord from time to time promptly on demand, as Additional Rent. 

(c) Operatorless passenger elevator service in common with other tenants for ingress and egress from the
Premises, provided that Landlord may reasonably limit the number of elevators to be in 

  
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operation at times other than Normal Business Hours. If there are any service elevators in the Building, Tenant may use them in common with other tenants on a first come, first served basis, but
only when scheduled through the management of the Building and Tenant shall pay Landlord’s reasonable charges therefor, as Additional Rent. 

(d) Janitorial service on a five (5) day week basis on weekdays only and not on Holidays; provided,
however, if Tenant’s floor covering or other improvements is other than Building standard, Tenant shall pay the additional and reasonable cleaning costs attributable thereto as Additional Rent. Tenant shall permit access to the Premises for the
janitorial service after 6:00 p.m. 
 (e) Electric current in the manner and to the extent deemed by Landlord
to be standard for medical office use, but not to exceed three (3) watts per rentable square foot in the Premises. 

(g) Landlord shall provide the parking described in Rider 101 attached to this 

(h) Lease Disposal of Tenant’s normal rubbish and trash; provided however, Landlord shall have no duty or
obligation to remove any Medical Waste from the Premises. Tenant covenants and agrees, at its sole cost and expense, to comply with all present and future applicable laws regarding the collection, sorting, separation and recycling of waste products,
garbage, refuse and trash. 
 Failure to any extent to furnish or any interruption of these defined utilities and services
resulting from any cause whatsoever shall not render Landlord liable in any respect for damages to either person, property or business, nor be construed as an eviction of Tenant, nor entitle Tenant to any abatement of rent, nor relieve Tenant from
fulfillment of any covenant or agreement contained herein; provided that if the Premises become untenantable due to any failure or interruption of such utilities and services (regardless of cause), then Tenant shall be entitled to rental abatement
to the extent Landlord is entitled to rentable abatement insurance as a result thereof. Should any malfunction of the Building improvements or facilities (which by definition do not include any improvements or facilities of Tenant beside Building
standard improvements) occur for any reason, Landlord shall use reasonable diligence to repair same promptly, but Tenant shall have no claim for rebate or abatement of rent or damages on account of such malfunction or of any interruptions in service
occasioned thereby or resulting therefrom. 
 4. Additional Rent. 

(a) Tenant shall during the Lease Term pay an amount (the “Operating Expense Payment”) equal
to the product of (x) Tenant’s Proportionate Share, and (y) the excess from time to time of the Operating Expenses over the Base Expense Amount. Prior to the commencement of each calendar year of Tenant’s occupancy, Landlord may
make a good faith estimate of the anticipated amount of Tenant’s Operating Expense Payment (“Estimated Operating Expense Payment”) and Tenant agrees to pay the Estimated Operating Expense Payment in equal monthly installments
in advance and without demand on the first day of each calendar month during and throughout the Lease Term and any renewal or extension thereof, subject to adjustment of Estimated Operating Expense Payment pursuant to any audit conducted pursuant to
Paragraph 4(c) hereof. 
 (b) Within 150 days after the end of each calendar year during the Lease Term and
any renewal or extension thereof, or as soon as reasonably possible thereafter, Landlord shall provide Tenant a statement (the “Year End Statement”) showing the Operating Expenses for said calendar year, which Statement shall also
compare Estimated Operating Expense Payment theretofore paid by Tenant with actual Operating Expense Payment. In the event that the Estimated Operating Expense Payment paid by Tenant exceeds the actual Operating Expense Payment for said calendar
year, Landlord, at Landlord’s option, shall either pay Tenant an amount equal to such excess by direct payment to Tenant within thirty (30) days of the date of the Year End Statement, or credit such excess payment against the next accruing
installment(s) of the Estimated Operating Expense Payment. In the event that the Tenant’s Additional Rent exceeds Tenant’s Forecast Additional Rent for said calendar year, Tenant shall pay Landlord, within thirty (30) days of receipt
of the Year End Statement, an amount equal to such difference. Such obligation of Landlord to refund and of Tenant to pay shall survive expiration or termination of this Lease. Landlord’s Year End Statement showing Operating Expenses shall be
conclusive and binding for all purposes on Tenant as to any and all items contained therein to which Tenant has not objected in writing to Landlord within thirty (30) days after Tenant’s receipt of such Statement, which writing shall
specify each item objected to and the detailed reason for each such objection. Landlord’s failure to render a Year End Statement during 

  
 3 

 
or with respect to any year in question shall not prejudice Landlord’s right to render a Year End Statement during or with respect to any subsequent year during the Lease Term, and shall not
eliminate or reduce Tenant’s obligation to make payments of the Operating Expense Payment under this Article for the calendar year for which no Year End Statement was provided. 

(c) Tenant at its sole expense shall have the right during the Lease Term, but no more frequently than once per
calendar year following prior written notice to Landlord, to audit Landlord’s books and records relating to Operating Expenses, or at Landlord’s sole election, Landlord will provide at Tenant’s reasonable expense a copy of such audit
prepared by an independent certified public accountant. Any audit right must be exercised within 90 days after receipt of the Year End Statement. Tenant’s audit rights shall survive 90 days after the expiration or termination of the Lease Term
at which time the rights shall expire. 
 (d) Notwithstanding anything to the contrary contained herein, if
the Building is not fully occupied during any calendar year of the Lease Term, Operating Expenses (or such components thereof as Landlord may reasonably elect), the Estimated Operating Expense Payment and the Operating Expense Payment for purposes
of this Paragraph 4 shall be determined as if the Building had been fully occupied during such year and Operating Expenses had been in an amount which would be normal if the Building were fully occupied; provided that the adjustment described in
this sentence shall not apply to ad valorem taxes or insurance on the Building and Land. For the purposes of this Lease, “fully occupied” shall mean occupancy of ninety-five percent (95%) of the rentable area of the Building.

 (e) The term “Operating Expenses” shall mean all costs of management, operation
(including the cost of providing electrical service to the Building and tenants in the Building to the extent such tenants are not separately metered), and maintenance of the Land, the Building, and all other improvements on the Land and any and all
appurtenances thereto (the “Common Facilities”), all accrued and based on an annual period consisting of a calendar year. By way of illustration but not limitation, Operating Expenses shall include expenditures for maintenance and
repairs; amortization of any capital expenditures in accordance with generally accepted accounting practices and principles which are incurred by Landlord to (i) attempt to effect a reduction in the Operating Expenses of the Building, or
(ii) keep the Building in compliance with all applicable governmental rules and regulations from time to time; assessments and governmental charges (including taxes on rents or services); ad valorem property taxes with respect to the Land
and/or the Building or any part of either thereof and all taxes of whatsoever nature that are imposed in substitution for or in lieu of any of the taxes, assessments or other charges herein described; charges for water, sewerage, and gas; cleaning,
including supplies, janitorial services and pest control; licenses, permits and inspection fees; refuse collection; insurance; administrative expenses, including salaries, benefits, taxes and other expenses for labor and management, office
equipment, telephone, and supplies; management fees payable by Landlord with respect to the Land, Building and Common Facilities (management fees capped at 5% of gross rental receipts from the Building); fire protection; snow and ice removal;
landscape maintenance; professional services (including legal, property-related consulting and accounting expenses); and security services. The following shall be excluded from Operating Expenses: depreciation; capital expenditures other than those
referenced in the previous sentence; cost of Building alterations or renovations for other tenants in the Building; advertising; commissions or fees paid for leasing; cost of repairs occasioned by fire, windstorm, or other casualty (but only to the
extent reimbursed by insurance proceeds); and wages, salaries, or other compensation paid to any executive above the grade of building manager, Landlord’s general corporate overhead, costs reimbursed by warranties, sale or refinancing of
Building, Landlord’s violation of any Requirements, contributions to political, civic or charitable organizations, art, sculptures or paintings in the Building, or reserves of any kind. 

(f) The provisions of this Article shall survive the expiration or earlier termination of this Lease. 

5. Electricity. 

(a) If Landlord, in its sole discretion, believes that Tenant is consuming substantially more than its
proportionate share of electrical power allocable to the Premises, Landlord may, in its sole discretion, require the Premises to be submetered, with the cost of such submetering to be at the sole cost and expense of Tenant. Upon installation of such
submeters, Tenant shall pay to Landlord for Tenant’s actual cost of consumption of electricity service as measured and calculated by Landlord, plus Landlord’s administrative charges for reading such meter, as Additional Rent. 

  
 4 

 (b) Without Landlord’s prior written consent, Tenant shall
not install any equipment (such as, without limitation, tabulating or computing equipment) in the Premises that will require any electrical current or equipment for its use other than that supplied by Landlord for normal general office usage, and
the cost of special electrical installations approved by Landlord shall be paid by Tenant to Landlord on demand. Tenant shall at all times comply with the rules, regulations, terms and conditions applicable to service, equipment, wiring and
requirements of the public utility supplying electricity to the Building. 
 (c) Landlord shall not be liable
in any way to Tenant for any failure or defect in the supply or character of electric service furnished to the Premises by reason of any Requirement, act or omission of (he utility serving the Building or for any other reason (except to the extent
attributable to the negligence or misconduct of Landlord) or whether electricity is provided by public or private utility or by any electricity generation system owned and operated by Landlord. 

(d) If Landlord shall be required by any Requirement or the public utility providing electricity to the
Building to discontinue furnishing electricity to Tenant, this Lease shall continue in full force and effect and shall be unaffected thereby, except only that from and after the effective date of such discontinuance, Landlord, on not less than 90
days’ notice (or such shorter period as may be required by Requirements or the public utility), shall not be obligated to furnish electricity to Tenant from the date of discontinuance. In such event, Tenant shall obtain electric energy directly
from the public utility furnishing electric service to the Building and the costs of such service shall be paid by Tenant directly to such public utility. Such electricity may be furnished to Tenant by means of the existing electrical facilities
serving the Premises, at no charge, to the extent the same are safe for such purposes and as determined by Requirements. All meters and all additional panel boards, feeders, risers, wiring and other conductors and equipment that may be required to
obtain electricity shall be installed by Landlord, at Landlord’s cost. Landlord, to the extent permitted by applicable Requirements, shall not discontinue furnishing electricity to the Premises until such installations have been made so that
Tenant shall be able to obtain electricity directly from the public utility. 
 6. Payments and Performance.
Except as otherwise expressly provided in this Lease, Tenant agrees to pay all Rental and sums provided to be paid by Tenant hereunder at the times and in the manner herein provided, without any setoff, deduction or counterclaim whatsoever. Should
this Lease commence on a day other than the first day of a calendar month or terminate on a day other than the last day of a calendar month, the Rental for such partial month shall be proportionately reduced. The Base Rental for the first partial
month, if any, shall be payable at the beginning of said period or as Prepaid Rental. The obligation of Tenant to pay such rent is an independent covenant, and no act or circumstance whatsoever, whether such act or circumstance constitutes a breach
of covenant by Landlord or not, shall release Tenant from the obligation to pay rent. Time is of the essence in the performance of all of Tenant’s obligations hereunder. Any amount which becomes owing by Tenant to Landlord hereunder shall bear
interest at the Default Rate. In addition, at Landlord’s option, but only to the extent allowed by applicable law and not in excess of the amount allowed by applicable law, Tenant shall pay a late charge in the amount (as solely determined by
Landlord) of up to five percent (5%) of any installment of Rental hereunder which is not paid within five (5) days of the date on which it is due in order to compensate Landlord for the additional expense involved in handling delinquent
payments. 
 7. Tenant Plans and Specifications - Installation of Improvements. Landlord will install or cause
to be installed in the Premises all improvements shown on the Approved Working Drawings (as defined in Exhibit “D” attached hereto) upon the terms and conditions set forth in the Leasehold Improvements Agreement attached hereto as
Exhibit “D” and made a part hereof. 
 8. Completion of Improvements and Commencement of
Rent. If the Premises are not ready for occupancy by Tenant on the Commencement Date pursuant to the terms of Exhibit “D”, the obligations of Landlord and Tenant shall nevertheless continue in full force and effect,
including the obligation of Tenant to commence paying rent on the Commencement Date, provided that if the Premises are not ready for occupancy on the Commencement Date for any reason other than Tenant’s Delay (as defined in
Exhibit “D”), then the Base Rental shall abate and not commence until the date the leasehold improvements to the Premises are substantially complete or until the date Tenant commences occupancy of any portion of the Premises,
whichever first occurs (such first occurring date being herein referred to as the “Actual Commencement Date”). Any such abatement of Base 

  
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Rental, however, shall constitute full settlement of all claims that Tenant might otherwise have against Landlord by reason of the Premises not being ready for occupancy by Tenant on the
Commencement Date. If the Premises are not ready for occupancy by Tenant on the Commencement Date, the number of months of the Lease Term will remain as stated in the Basic Lease Information, and the Lease Term will commence on the Actual
Commencement Date. Notwithstanding the foregoing, if Tenant, with Landlord’s consent, occupies the Premises after substantial completion of Tenant’s leasehold improvements but prior to the beginning of the Lease Term set forth herein, all
of the terms and provisions of this Lease shall be in full force and effect from the commencement of such occupancy and the Lease Term shall commence on the earlier date on which Tenant first occupies the Premises and shall expire the same number of
months thereafter as shown in the Basic Lease Information and no change shall occur in the length of the Lease Term. By moving into the Premises or taking possession thereof, Tenant accepts the Premises as suitable for the purposes for which the
same are leased and accepts the Building and every appurtenance thereof, and waives any and all defects therein and on request from Landlord, Tenant shall promptly execute and deliver to Landlord an Acceptance of Premises Memorandum in the form
attached hereto as Exhibit “E” and made a part hereof for all purposes. 
 9. Relocation of
Premises. Landlord reserves the right to designate another location in the Building for the Premises at any time during the Lease Term, and if Landlord elects to so designate a new location for the Premises, Tenant will vacate the old
Premises and move into the new Premises (which will contain substantially the same number of square feet of rentable square feet as the old Premises) when the finish-out improvements therein are substantially completed; provided, however, that
Tenant shall be notified in writing at least sixty (60) days prior to said relocation, and Landlord shall pay all reasonable out-of-pocket moving expenses, reprinted stationary and business cards, postage for mailing change of address notices
(not to exceed $500) and all reasonable expenses for redesigning and remodeling the new Premises in a manner reasonably comparable to the design of the old Premises. In the event the Premises are relocated, Base Rental, Tenant’s Additional
Rental, and the Electricity Charge shall thereafter be calculated hereunder on the basis of the total rentable square feet of the new Premises. 

10. Repairs and Reentry. Tenant will, at Tenant’s own cost and expense, maintain and keep the Premises,
including distribution lines for building systems located within or serving only the Premises, including electrical systems and plumbing, and shall make all nonstructural repairs thereto as and when needed to preserve them in good working order and
condition. Subject to the foregoing and the waiver of subrogation, all damage or injury to the Premises or to any other part of the Building and building systems not exclusively serving the Premises, or to its fixtures, equipment and appurtenances,
whether requiring structural or nonstructural repairs, caused by or resulting from the neglect, or wrongful conduct of, or alterations made by, Tenant or Tenant’s agents, employees, invitees or licensees, shall be repaired at Tenant’s sole
cost and expense (at commercially reasonable rates), by Tenant (if the required repairs (i) are nonstructural in nature, or (ii) affect any building system that services the Premises exclusively and does not adversely affect the proper
functioning of any building system that does not service the Premises exclusively), or by Landlord (in all other circumstances). The performance by Tenant of its obligation to maintain and make repairs shall be conducted only by contractors approved
by Landlord after plans and specifications therefor have been approved by Landlord. If Tenant fails to make such repairs or replacements promptly, Landlord may, at its option, make repairs or replacement, and Tenant shall repay on demand the cost
thereof plus a charge of fifteen percent (15%) of such costs for overhead to Landlord. Tenant will not commit or allow any waste or damage to be committed on any portion of the Premises, and upon the termination of this Lease by lapse of time
or otherwise, Tenant shall deliver up the Premises to Landlord in as good condition as at date of possession, ordinary wear and tear and casualty damage excepted. Upon such termination of this Lease, Landlord shall have the right to reenter and
resume possession of the Premises. Notwithstanding the foregoing provisions of this Paragraph, any repairs to the Premises or the Building that are necessitated because of any damage caused by fire or other casualty shall be governed by the
provisions of Paragraph 22 below. Landlord shall be responsible for maintenance and repair to the exterior, structural and Common Areas of the Building and all mechanical, electrical, HVAC and plumbing systems servicing the Building. 

11. Assignment and Subletting. In the event that Tenant desires to assign this Lease or sublet all or any part
of the Premises or grant any license, concession or other right of occupancy of any portion of the Premises, Tenant shall notify Landlord in writing at least thirty (30) days before the commencement date of such assignment or sublease and shall
state the name of the proposed assignee, sublessee or other transferee and the terms of the proposed assignment, sublease or transfer. Tenant shall also provide financial information and state the nature and character of the business of the proposed
assignee, sublessee or transferee. Landlord shall have the option to retake possession of the Premises and terminate this Lease as of the date on which the proposed assignment, sublease or other transfer was to become effective. Landlord must
exercise such option to retake the Premises by giving written notice to Tenant within thirty (30) days after receipt of Tenant’s notice or Landlord will be deemed to have rejected 

  
 6 

 
its option to retake the Premises. If Landlord fails to exercise its option to retake the Premises, Tenant shall not assign this Lease or any right hereunder or interest herein, and Tenant shall
not sublet the Premises in whole or in part or grant any license, concession or other right of occupancy of any portion of the Premises, without the prior written consent of Landlord, which consent shall not be unreasonably withheld, conditioned or
delayed. Any such assignment or subletting without such consent shall be void and shall, at the sole option of the Landlord, be deemed an Event of Default by Tenant under this Lease. Notwithstanding any assignment or subletting consented to by
Landlord, Tenant and any guarantor of Tenant’s obligations under this Lease and each assignee shall at all times remain fully responsible and liable for the payment of the rent herein specified and for compliance with all of Tenant’s other
covenants and obligations under this Lease. No consent to any assignment of this Lease or any subletting of the Premises shall constitute a waiver of the provisions of this Paragraph except as to the specific instance covered thereby. In the event
that the monthly rental per square foot of space subleased which is payable by any sublessee to Tenant shall exceed the monthly rental per square foot for the same space payable for the same month by Tenant to Landlord (including any bonuses or any
other consideration paid directly or indirectly by the sublessee to Tenant), Tenant shall be obligated to pay the amount of such excess to Landlord as additional rent hereunder on the same date it is received by Tenant from the sublessee. In the
event Tenant shall receive any consideration from an assignee other than the assumption by the assignee of Tenant’s obligations hereunder, Tenant shall be obligated to pay the full amount of such consideration to Landlord as additional rent
hereunder on the same date it is received by Tenant. Landlord, at Landlord’s option, may elect to require that rental payable by any sublessee be paid directly to Landlord and offset Tenant’s rent obligations accordingly. At no time during
the Lease Term shall Tenant be entitled to (i) advertise the Premises for sublease without the prior written consent of Landlord, such consent not to be unreasonably withheld and (ii) market the Premises for sublease at a rate less than
the fair market value of the Premises. If Tenant is a corporation or partnership, an assignment prohibited by this Paragraph 11 shall be deemed to include one or more sales or transfers, by operation of law or otherwise, or creation of new stock or
partnership interests, by which a majority of the voting shares of the corporation or interests in the partnership shall be vested in a party or parties who are not owners of a majority of the voting shares or partnership interests of Tenant as of
the date hereof; provided, however, that the foregoing provisions of this sentence shall not be applicable if (i) Tenant’s stock is listed on a recognized securities exchange or (ii) at least eighty percent (80%) of Tenant’s
stock is owned by a corporation whose stock is listed on a recognized securities exchange. For the purposes hereof, stock ownership shall be determined in accordance with the principles set forth in section 544 of the Internal Revenue Code of 1986,
as amended to the date hereof. Any transfer by operation of law shall also constitute an assignment prohibited by this Paragraph 11. Tenant shall reimburse Landlord, on demand, for its reasonable attorneys’ fees and other expenses incurred in
connection with considering any request for Landlord’s consent to an assignment or sublease of the Premises. Notwithstanding the foregoing, Landlord agrees that no consent will be required for any sublease or other office sharing agreement
Tenant enters into from time to time with any affiliate or other business partner so long as Tenant continues to occupy the Premises and the space used by such third party is not separately demised. 

12. Alterations and Additions by Tenant. Tenant shall make no alterations, installations, improvements,
additions or other physical changes in or about the Premises (collectively, “Alterations”) without the prior written consent of Landlord; and all Alterations placed in or upon the Premises by either party (except only moveable trade
fixtures of Tenant) shall be deemed a part of the Building and the property of the Landlord at the time they are placed in or upon the Premises, and they shall remain upon and be surrendered with the Premises as a part thereof at the termination of
this Lease, unless Landlord shall elect otherwise, whether such termination shall occur by the lapse of time or otherwise. In the event Landlord shall elect that certain Alterations made by Tenant in the Premises shall be removed by Tenant, Tenant
shall remove them and Tenant shall restore the Premises to its original condition, at Tenant’s own cost and expense, prior to the termination of the Lease Term. At Landlord’s election, Alterations will be performed by Landlord at
Tenant’s cost and expense, including a charge of fifteen percent (15%) of the cost of such Alterations for Landlord’s overhead. 

13. Legal Use; Violations of Insurance Coverage; Nuisance. Tenant will not occupy or use any portion of the
Premises for any use or purpose other than the Sole Permitted Use or for any purpose which is unlawful or which, in the reasonable judgment of Landlord, is disreputable or which is hazardous due to risk of fire, explosion or other casualty, nor
permit anything to be done which will in any way (i) increase the rate of fire and casualty insurance on the Building or its contents, or (ii) tend to lower the first-class character and reputation of the Building, or (iii) create
unreasonable elevator loads or otherwise interfere with standard Building operations, or (iv) affect the structural integrity or design capabilities of the Building. In the event that, by reason of any act or conduct of business of Tenant,
there shall be any increase in the rate of insurance on the Building or its contents created by Tenant’s acts or conduct of business, then Tenant hereby agrees to pay Landlord the amount of such increase on demand. Tenant shall not erect,
place, or allow to be placed any sign, advertising matter, stand, booth or showcase in, upon or visible from the vestibules, halls, corridors, doors, outside walls, outside windows or pavement 

  
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of the Building or the Land without the prior written consent of Landlord. Tenant will conduct its business, and control its agents, employees, and invitees in such a manner as not to create any
nuisance or interfere with, annoy or disturb other tenants or Landlord in the management of the Building. Tenant shall apply for, secure, maintain and comply with all licenses, permits and certificates from appropriate governmental authorities which
may be required for the conduct by Tenant of the Sole Permitted Use, including for any equipment and machinery used within the Premises, and to pay, if, as and when due all license and permit fees and charges of a similar nature in connection
therewith and provide Landlord with copies thereof upon request. Tenant represents and warrants to Landlord that all health care services will be provided by licensed professionals in good standing, that delivery of health care services will be
under the supervision of a licensed professional and that services shall be provided in compliance with the practice guidelines established by the respective specialty’s oversight association. 

14. Laws and Regulations. Tenant at its sole expense will maintain the Premises in a clean and healthful
condition and will comply with all Requirements. Landlord will maintain the Building and Land in a clean and healthful condition and will comply with all Requirements. 

15. Indemnity, Liability and Loss or Damage. Landlord shall not be liable to Tenant or Tenant’s agents,
employees, guests, invitees or any person claiming by, through or under Tenant for any injury to person, loss of or damage to property, or for loss of or damage to Tenant’s business, occasioned by or through the acts or omissions of Landlord,
or by any cause whatsoever except for any thereof arising solely from or out of Landlord’s gross negligence or willful wrongdoing. Unless arising solely from or out of Landlord’s gross negligence or willful wrongdoing, Landlord shall not
be liable for, and Tenant shall indemnify Landlord and save it harmless from, all suits, actions, damages, liability and expense in connection with loss of life, bodily or personal injury or property damage arising from or out of any occurrence in,
upon, at or from the Premises or the occupancy or use by Tenant of the Premises or any part thereof, or occasioned wholly or in part by any action or omission of Tenant, its agents, contractors, employees, invitees, or licensees. If Landlord shall
be made a party to any action commenced by or against Tenant, Tenant shall protect and hold Landlord harmless therefrom and on demand shall pay all costs, expenses, and reasonable attorney’s fees incurred by Landlord in connection therewith.

 16. Rules of the Building. Tenant will comply fully, and will cause Tenant’s agents, employees, and
invitees to comply fully with all Rules and Regulations of the Building which are attached hereto as Exhibit “F” and made a part hereof as though fully set out herein. As more particularly provided therein, Landlord shall at all
times have the right to change such Rules and Regulations or to amend them in such reasonable manner as Landlord may deem advisable for the safety, protection, care and cleanliness of the Building and appurtenances and for preservation of good order
therein, all of which Rules and Regulations, changes and amendments will be forwarded to Tenant in writing and shall be complied with and observed by Tenant and Tenant’s agents, employees and invitees. In the event of any conflict between the
current or future Rules and Regulations and the remainder of this Lease, the latter shall control. 
 17. Entry for
Repairs and Inspection. Landlord and its agents and representatives shall have the right to enter into and upon any and all parts of the Premises at all reasonable hours (or, in an emergency, at any hour), to inspect same or clean or make
repairs or alterations or additions to the Building and the Premises (whether structural or otherwise) as Landlord may deem necessary, and during the continuance of any such work, Landlord may temporarily close doors, entryways, public spaces and
corridors and interrupt or temporarily suspend Building services and facilities, and Tenant shall not be entitled to any abatement or reduction of rent by reason thereof. Landlord agrees, however, that it will use commercially reasonable efforts to
limit the inconvenience to and disruption of Tenant’s normal business operations. During the Lease Term, Landlord may exhibit the Premises to prospective purchasers and lenders at reasonable hours and upon prior notice to Tenant. Furthermore,
during the one-year period prior to the Expiration Date, Landlord and Landlord’s agents may exhibit the Premises to prospective tenants during Normal Business Hours and upon prior notice to Tenant. 

18. Condemnation. If all of the Premises, or so much thereof as would materially interfere with Tenant’s
use of the remainder, shall be taken or condemned for any public use or purpose by right of eminent domain, with or without litigation, or be transferred by agreement in connection with or in lieu of or under threat of condemnation, then the Lease
Term and the leasehold estate created hereby shall terminate as of the date title shall vest in the condemnor or transferee. If all or any portion of the Building is taken or condemned or transferred as aforesaid, Landlord shall have the option to
terminate this Lease effective as of the date title shall vest in the condemnor or transferee. Landlord shall receive the entire award from any taking or condemnation (or the entire compensation paid because of any transfer by agreement), and Tenant
shall have no claim thereto. 

  
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 19. Landlord’s Lien and Security Interest. Landlord shall have
a Landlord’s statutory lien, and in addition thereto Landlord shall have, and Tenant hereby grants unto Landlord, a security interest in all of the goods, wares, furniture, fixtures, office equipment, supplies and other property of Tenant now
or hereafter placed in, upon, or about the Premises and all proceeds thereof, as security for all of the obligations of Tenant under this Lease, Tenant shall not remove any of said personal properly from the Premises until all of Tenant’s
obligations under this Lease have been satisfied in full. Upon the occurrence of an Event of Default by Tenant, Landlord may, in addition to any other remedies provided herein, enter upon the Premises and take possession of any and all goods, wares,
equipment, fixtures, furniture, improvements and other personal property of Tenant situated on the Premises, without liability for trespass or conversion, and sell the same at public or private sale, with or without having such property at the sale,
after giving Tenant reasonable notice of the time and place of any public sale or of the time after which any private sale is to be made; and at any such sale the Landlord or its assigns may purchase unless otherwise prohibited by law. The proceeds
from any such disposition, less any and all expenses connected with the taking of possession, holding and selling of the property (including reasonable attorney’s fees and other expenses), shall be applied as a credit against the indebtedness
secured by the security interest granted in this Paragraph. Any surplus shall be paid to Tenant or as otherwise required by law and Tenant shall pay any deficiencies forthwith to Landlord. Upon request by Landlord, Tenant agrees to execute and
deliver to Landlord a financing statement in form sufficient to perfect the security interest of Landlord in the aforementioned property and proceeds thereof under the provisions of the Texas Uniform Commercial Code. Upon request by Landlord, Tenant
shall provide the name and address of any entity that has, or claims to have, an interest (including, without limitation, a security interest) in any properly located on the Premises and a description of such property. Failure to provide such list
shall result in a presumption that all property located in the Premises belongs to Tenant free from all claims. Without intending to exclude any other manner of giving Tenant any required notice, any requirement of reasonable notice to Tenant of
Landlord’s intention to dispose of any collateral pursuant to the enforcement of said security interest shall be met if such notice is given in the manner prescribed in Paragraph 32 of this Lease at least five (5) days before the time of
any such disposition. Landlord shall have all of the rights and remedies of a secured party under law. The foregoing notwithstanding, Landlord hereby waives any statutory or contractual lien relating to PHI and expressly excludes PHI from any
security agreement and from any Uniform Commercial Code financing statement perfecting a landlord lien in property at the Premises. Landlord agrees that if it obtains possession of any PHI due to foreclosure of any security interest, eviction, or
other exercise of repossession, that it shall treat the PHI in compliance with applicable Requirements and shall, at Tenant’s sole cost and expense, return PHI to Tenant, to the extent practicable, or if impracticable, shall destroy the PHI in
a secure fashion without disclosing PHI to third parties, by a professional disposal company which serves attorneys, physicians and similar professionals with on-going needs to appropriately destroy confidential information, as if the Lease were
terminated. 
 20. Abandoned Property. Subject to applicable Requirements, all personal property of Tenant
remaining in the Premises after the termination or expiration of the Lease Term or after the abandonment of the Premises by Tenant may be treated by Landlord as having been abandoned by Tenant and Landlord may, at its option and election, thereafter
take possession of such property and either (i) declare same to be the property of Landlord, or (ii) at the cost and expense of Tenant, store and/or dispose of such property in any manner and for whatever consideration, Landlord, in its
sole discretion, shall deem advisable. The foregoing notwithstanding, Landlord, if feasible, will return or destroy all PHI received from, or created or received by Landlord on behalf of Tenant that Landlord still maintains in any form and will
retain no copies of such information or, if such return or destruction is not feasible, shall notify Tenant of the condition that makes the return or destruction of PHI not feasible and shall extend the protections of this Lease to the PHI and limit
further uses and disclosures to those purposes that make the return or destruction of the PHI infeasible for so long as Landlord maintains such PHI. Tenant shall be presumed conclusively to have abandoned the Premises if the amount of Tenant’s
property removed by Tenant from the Premises is substantial enough to indicate a probable intent to abandon the Premises and such removal is not in the normal course of Tenant’s business, or if Tenant removes any material amount of
Tenant’s personal property from the Premises, at a time when Tenant is in default in the payment of Rental due hereunder or in the performance of any other obligation of Tenant hereunder and such removal is not in the normal course of
Tenant’s business. Nothing contained in this Paragraph shall prejudice or impair Landlord’s rights as a lienholder and secured party under Paragraph 19 hereof, and the rights granted to Landlord under this Paragraph shall be cumulative of
its rights as a lienholder and secured party. 
 21. Surrender of Premises; Holding Over. Upon the expiration
or other termination of this Lease, Tenant shall quit and surrender to Landlord the Premises, vacant and broom clean, free from Medical Waste and the effects of Medical Waste with any damage to the Premises and the Building caused by the removal by
Tenant of any Alterations or Tenant’s personal property from the Premises repaired in a good and workmanlike manner. Tenant expressly waives, for itself and for any person claiming through or under Tenant, any rights that Tenant or any such
person may have under any law then in force in connection with any holdover summary proceedings that Landlord 

  
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may institute to enforce the foregoing provisions of this Article. Tenant acknowledges that possession of the Premises must be surrendered on or before 11:59 p.m. to Landlord on the Expiration
Date. Should Tenant continue to hold the Premises after this Lease terminates, whether by lapse of time or otherwise, then a holdover shall be created and such holding over shall, unless otherwise agreed by Landlord in writing, constitute and be
construed as a tenancy at will and Tenant shall pay to Landlord on account of use and occupancy of the Premises, without limiting any other right or remedy of Landlord, for each month or partial month in which Tenant holds over in the Premises after
the Expiration Date, a sum equal to 175% of the monthly bas rent in effect immediately prior to the expiration of termination of the Lease, and upon and subject to all of the other terms and provisions set forth herein except any right to renew this
Lease, expand the Premises or lease additional space. This provision shall not be construed, however, as permission by Landlord for Tenant to holdover. No payments of money by Tenant to Landlord after the termination of this Lease shall reinstate,
continue, or extend the Lease Term and no extension of this Lease after the termination hereof shall be valid unless and until the same shall be reduced to writing and signed by both Landlord and Tenant. Tenant shall be liable to Landlord for all
damage which Landlord shall suffer by reason of any holding over by Tenant, and Tenant shall indemnify, defend and hold harmless Landlord from and against all net loss, cost, liability and expense that Landlord may suffer as a result of
Tenant’s holding over, including Legal Costs and against any claims made by any other tenant or prospective tenant against Landlord resulting from delay by Landlord in delivering possession of the Premises (or any portion thereof) to such other
tenant or prospective tenant. The provisions of this Article shall survive the expiration or earlier termination of this Lease. 

22. Fire and Casualty. 

(a) In the event of a fire or other casualty in the Premises, Tenant shall immediately give verbal notice
thereof to Landlord, followed by written confirmation thereof within three (3) days of such fire or other casualty. If the Premises are damaged by fire or other casualty and if such damage is not susceptible of repair within 180 days (as
estimated, as soon as reasonably practicable after the occurrence of such damage, by an architect of recognized good reputation selected by Landlord), then in such event this Lease, at the option of Landlord, exercised by giving written notice
thereof to Tenant within thirty (30) days after receipt of such written estimate of the architect so selected, shall terminate as of the date of such loss, and Tenant shall pay the rent hereunder apportioned to the time of such loss and shall
pay all other obligations of Tenant owing on the date of termination, and Tenant shall immediately surrender the Premises to Landlord in the condition required by the terms of this Lease. 

(b) If the damage described above is susceptible of repair within 180 days, or if the damage is not susceptible
of repair within 180 days but Landlord fails to exercise its option to terminate this Lease, and so long as Landlord does not elect to terminate the Lease pursuant to Subparagraph (c) below, Landlord shall enter and make the necessary repairs
without affecting this Lease, but the rent hereunder shall be reduced or abated as shall be equitable, in the good faith judgment of Landlord, until such repairs are made, unless such damage has been so slight that Tenant’s occupancy of the
Premises is not materially interfered with, in which case the rent hereunder shall not be abated or reduced. Notwithstanding the foregoing, Landlord shall have the option to terminate this Lease and shall not be obligated to repair the Premises or
the Building if the damage is not covered by insurance or if Landlord’s mortgagee applies any portion of the insurance proceeds to the unpaid balance of its loan. 

(c) In the event the Building is so badly damaged or injured by fire or other casualty, even though the
Premises may not be affected, that Landlord decides, within ninety (90) days after such destruction, not to rebuild or repair the Building (such decision being vested exclusively in the discretion of Landlord), then in such event Landlord shall
so notify Tenant in writing and this Lease shall terminate as of the date specified for termination in the notice from Landlord to Tenant, and the Tenant shall pay rent hereunder apportioned to the date of such termination and shall pay all other
obligations of Tenant owing on the date of termination, and Tenant shall immediately surrender the Premises to Landlord in the condition required by this Lease. 

(d) Notwithstanding the foregoing provisions of this Paragraph, Tenant agrees that if the Premises or any other
portion of the Building is damaged by fire or other casualty resulting from the fault or negligence of Tenant or any of its agents, employees, or invitees, then the cost of restoring the property damage in excess of any property insurance proceeds
paid to Landlord shall be paid by Tenant on demand, and there shall be no abatement of rent before or during the repair of such damage, unless Landlord has business interruption insurance in effect in which event rent shall abate to the extent of
Landlord’s receipt of insurance proceeds. 
 (e) Notwithstanding the foregoing, if the Premises are
substantially damaged in the last year of the Lease Term (as renewed or extended), Landlord may elect by written notice, given within 30 days after the occurrence of such damage, to terminate this Lease. 

  
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 23. Entire Agreement and Amendment; No Representations or Warranties; No
Memorandum of Lease. This Lease contains the entire agreement between the parties hereto with respect to the subject matter hereof and supersedes any and all prior and contemporaneous agreements, understandings, promises, and representations
made by either party to the other concerning the subject matter hereof and the terms applicable hereto. It is expressly agreed by Tenant, as a material consideration to Landlord for the execution of this Lease, that there have been no
representations, understandings, stipulations, agreements or promises pertaining to the Premises, the Building or this Lease not incorporated in writing herein. This Lease shall not be altered, waived, amended or extended, except by a written
agreement signed by the parties hereto, unless otherwise expressly provided herein. LANDLORD’S DUTIES AND WARRANTIES ARE LIMITED TO THOSE SET FORTH IN THIS LEASE, AND SHALL NOT INCLUDE ANY IMPLIED DUTIES OR WARRANTIES, ALL OF WHICH ARE HEREBY
DISCLAIMED BY LANDLORD AND WAIVED BY TENANT. Neither this Lease nor a memorandum of this Lease shall be recorded in the public records of the county in which the Building is located without the prior written consent of Landlord. 

24. Transfer of Landlord’s Rights. In the event Landlord transfers its interest in the Building and assigns
the Security Deposit to the new owner, Landlord shall thereby automatically be released from any further obligations hereunder, and Tenant agrees to look solely to the successor in interest of Landlord for the performance of such obligations. 

25. Default. 

(a) The following events shall be deemed to be Events of Default (herein so called) by Tenant under this Lease:

 (i) Tenant shall fail to pay any Rental or other sum payable by Tenant hereunder as and when such Rental
or other sum becomes due and payable; provided, however, that Tenant shall be entitled to receive, one (1) time each calendar year, a written notice of such failure from Landlord and a five (5) day period thereafter to cure such payment
default; 
 (ii) Tenant shall fail to comply with any other provision, condition or covenant of this Lease
and any such failure is not cured within five (5) days after Landlord gives written notice of such failure to Tenant or such longer period of time (not to exceed 60 days) as is reasonably required to cure such non-monetary default utilizing
Tenant’s diligent efforts; 
 (iii) Tenant shall assign this Lease or sublet all or any part of the
Premises or grant any license, concession or other right of occupancy of any portion of the Premises, without the prior written consent of Landlord; 

(iv) Any petition shall be filed by or against Tenant or any guarantor of Tenant’s obligations under this
Lease pursuant to any section or chapter of the present federal Bankruptcy Act or under any future federal Bankruptcy Act or under any similar law or statute of the United States or any state thereof (which as to any involuntary petition shall not
be and remain discharged or stayed within a period of thirty (30) days after its entry), or Tenant or any guarantor of Tenant’s obligations under this Lease shall be adjudged bankrupt or insolvent in proceedings filed under any section or
chapter of the present federal Bankruptcy Act or under any future federal bankruptcy act or under any similar law or statute of the United States or any state thereof; 

(v) Tenant or any guarantor of Tenant’s obligations under this Lease shall become insolvent or make a
transfer in fraud of creditors; 
 (vi) Tenant or any guarantor of this Lease shall make an assignment for
the benefit of creditors; or 
 (vii) A receiver or trustee shall be appointed for Tenant or any guarantor of
this Lease or for any of the assets of Tenant or any guarantor of this Lease. 

  
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 (b) Upon the occurrence of any Event of Default, Landlord shall
have the option to do any one or more of the following without any further notice or demand, in addition to and not in limitation of any other remedy permitted by law or by this Lease: 

(i) Enforce, by all legal suits and other means, its rights hereunder, including the collection of Base Rental,
Operating Expense Payment, Additional Rent and other sums payable by Tenant hereunder and the reimbursement for all unamortized tenant allowances and concessions, without reentering or resuming possession of the Premises and without terminating this
Lease. 
 (ii) Terminate this Lease by issuing written notice of termination to Tenant, in which event Tenant
shall immediately surrender the Premises to Landlord in the condition required by the terms of this Lease, but if Tenant shall fail to do so, Landlord may without notice and without prejudice to any other remedy Landlord may have, enter upon and
take possession of the Premises and expel or remove Tenant and its effects without being liable to prosecution or any claim for damages therefor, and upon any such termination, Tenant agrees that in addition to its liability for the payment of
arrearages of Base Rental, Additional Rent and other sums due and owing by Tenant to Landlord under this Lease upon such termination, Tenant shall be liable to Landlord for damages. Tenant shall pay to Landlord as damages on the same days as Base
Rental, Additional Rent and other payments which are expressed to be due under the provisions of this Lease, the total amount of such Base Rental, Additional Rent and other payments plus a reimbursement for all unamortized tenant allowances and
concessions, less such part, if any, of such payments that Landlord shall have been able to collect from a new tenant upon reletting; provided, however, that Landlord shall have no obligation to relet the Premises so as to mitigate the amount for
which Tenant is liable. Landlord shall have the right at any time to demand final settlement. Upon demand for a final settlement, Landlord shall have the right to receive, and Tenant hereby agrees to pay, as damages for Tenant’s breach, the
difference between the total Rental provided for in this Lease for the remainder of the Lease Term and the reasonable rental value of the Premises for such period, such difference to be discounted to present value at at the rate of 6% per
annum. 
 (iii) Enter upon and take possession of the Premises without terminating this Lease and expel or
remove Tenant and its effects therefrom without being liable to prosecution or any claim for damages therefor, and Landlord may relet the Premises for the account of Tenant. Tenant shall pay to Landlord all arrearages of Base Rental, Additional Rent
and other sums due and owing by Tenant to Landlord, and Tenant shall also pay to Landlord during each month of the unexpired Lease Term the installments of Base Rental, Additional Rent and other sums due hereunder, less such part, if any, that
Landlord shall have been able to collect from a new tenant upon reletting; provided, however, that Landlord shall have no obligation to relet the Premises so as to mitigate the amount for which Tenant is liable. In the event Landlord exercises the
rights and remedies afforded to it under this Paragraph 25(b)(iii) and then subsequently elects to terminate this Lease, Tenant shall be liable to Landlord for damages as set forth in Paragraph 25(b)(ii) above and Landlord shall have the right at
any time to demand final settlement as provided therein. 
 (iv) Landlord may do whatever Tenant is obligated
to do by the provisions of this Lease and may enter the Premises in order to accomplish this purpose. Tenant agrees to reimburse Landlord immediately upon demand for any expenses which Landlord may incur in its actions pursuant to this Subparagraph,
and Tenant further agrees that Landlord shall not be liable for damages resulting to Tenant from such action, whether caused by the negligence of Landlord or otherwise. 

(v) Landlord may enter upon the Premises and change, alter, or modify the door locks on all entry doors of the
Premises, and permanently or temporarily exclude Tenant, and its agents, employees, representatives and invitees, from the Premises. In the event that Landlord either permanently excludes Tenant from the Premises or terminates this Lease on account
of Tenant’s default, Landlord shall not be obligated thereafter to provide Tenant with a key to the Premises at any time, regardless of any amounts subsequently paid by Tenant. If Landlord elects to exclude Tenant from the Premises temporarily
without permanently repossessing the Premises 

  
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or terminating this Lease, then Landlord shall not be obligated to provide Tenant with a key to reenter the Premises until such time as all delinquent rent and other amounts due under this Lease
have been paid in full and all other defaults, if any, have been cured and Tenant shall have given Landlord evidence reasonably satisfactory to Landlord that Tenant has the ability to comply with its remaining obligations under this Lease; and if
Landlord temporarily excludes Tenant from the Premises, Landlord shall have the right thereafter to permanently exclude Tenant from the Premises or terminate this Lease at any time before Tenant pays all delinquent rent, cures all other defaults and
furnishes such evidence to Landlord. A key to the Premises will be furnished to Tenant only during Landlord’s Normal Business Hours. Landlord’s exclusion of Tenant from the Premises shall not constitute a permanent exclusion of Tenant from
the Premises or a termination of this Lease unless Landlord so notifies Tenant in writing. Landlord shall not be obligated to place a written notice on the Premises on the front door thereof explaining Landlord’s action or stating the name,
address or telephone number of any individual or company from which a new key may be obtained. In the event Landlord permanently or temporarily excludes Tenant from the Premises or terminates this Lease, and Tenant owns property that has been left
in the Premises but which is not subject to any statutory or contractual lien or security interest held by Landlord as security for Tenant’s obligations, Tenant shall have the right to promptly so notify Landlord in writing, specifying the
items of property not covered by any such lien or security interest and which Tenant desires to retrieve from the Premises. Landlord shall have the right to either (i) escort Tenant to the Premises to allow Tenant to retrieve Tenant’s property
not covered by any such lien or security interest, or (ii) remove such property itself and make it available to Tenant at a time and place designated by Landlord. In the event Landlord elects to remove such property itself as provided in the
immediately preceding clause (ii), Landlord shall not be obligated to remove such property or deliver it to Tenant unless Tenant shall pay to Landlord, in advance, an amount of cash equal to the amount that Landlord estimates Landlord will be
required to expend in order to remove such property and make it available to Tenant, including all moving or storage charges theretofore or thereafter incurred by Landlord with respect to such property. If Tenant pays such estimated amount to
Landlord and the actual amount incurred by Landlord differs from the estimated amount, Tenant shall pay any additional amounts to Landlord on demand or Landlord shall refund any excess amounts paid by Tenant to Tenant on demand. 

Pursuit of any of the foregoing remedies shall not preclude pursuit of any of the other remedies herein
provided or any other remedies provided by law or equity. Any entry by Landlord upon the Premises may be by use of a master or duplicate key or electronic pass card or any locksmith’s entry procedure or other means. Any reletting by Landlord
shall be without notice to Tenant, and if Landlord has not terminated this Lease, the reletting may be in the name of Tenant or Landlord, as Landlord shall elect. Any reletting shall be for such term or terms (which may be greater or less than the
period which, in the absence of a termination of this Lease, would otherwise constitute the balance of the Lease Term) and on such terms and conditions (which may include free rent, rent concessions or tenant inducements of any nature) as Landlord
in its absolute discretion may determine, and Landlord may collect and receive any rents payable by reason of such reletting. In the event of any reletting, Tenant shall pay to Landlord on demand the reasonable cost of renovating, repairing and
altering the Premises for a new tenant or tenants, and the reasonable cost of advertisements, brokerage fees, reasonable attorney’s fees and other costs and expenses incurred by Landlord in connection with such reletting. In the event any rents
actually collected by Landlord upon any such reletting for any calendar month are in excess of the amount of Rental payable by Tenant under this Lease for the same calendar month, the amount of such excess shall belong solely to Landlord and Tenant
shall have no right with respect thereto. In the event it is necessary for Landlord to institute suit against Tenant in order to collect the Rental due hereunder or any deficiency between the Rental provided for by this Lease for a calendar month
and the rent actually collected by Landlord for such calendar month, Landlord shall have the right to allow such deficiency to accumulate and to bring an action upon several or all of such rent deficiencies at one time. No suit shall prejudice in
any way the right of Landlord to bring a similar action for any subsequent rent deficiency or deficiencies. 
 26.
Waiver; Attorney’s Fees. No act or thing done by Landlord or its agents during the Lease Term shall be deemed an acceptance of an attempted surrender of the Premises, and no agreement to accept a surrender of the Premises shall be
valid unless made in writing and signed by Landlord. No reentry or taking possession of the Premises by Landlord shall be construed as an election on its part to terminate this Lease, unless a written notice of such intention, signed by Landlord, is
given by Landlord to Tenant. Notwithstanding any such reletting or reentry or 

  
 13 

 
taking possession, Landlord may at any time thereafter elect to terminate this Lease for a previous Event of Default, Landlord’s acceptance of rent following an Event of Default hereunder
shall not be construed as Landlord’s waiver of such Event of Default. No waiver by Landlord of any violation or breach of any of the terms, provisions and covenants herein contained shall be deemed or construed to constitute a waiver of any
other violation or breach of any of the terms, provisions and covenants herein contained. Forbearance by Landlord to enforce one or more of the remedies herein provided upon an Event of Default shall not be deemed or construed to constitute a waiver
of any other violation or default. The failure of Landlord to enforce any of the Rules and Regulations described in Paragraph 16 against Tenant or any other tenant in the Building shall not be deemed a waiver of any such Rules and Regulations. No
provision of this Lease shall be deemed to have been waived by Landlord unless such waiver is in writing and is signed by Landlord. The rights granted to Landlord in this Lease shall be cumulative of every other right or remedy which Landlord may
otherwise have at law or in equity, and the exercise of one or more rights or remedies shall not prejudice or impair the concurrent or subsequent exercise of other rights or remedies. If Landlord brings any action under this Lease, or consults or
places this Lease or any amount payable by Tenant hereunder with an attorney for the enforcement of any of Landlord’s rights hereunder, then Tenant agrees to pay to Landlord on demand Legal Costs incurred by Landlord in connection therewith.

 27. Quiet Possession. Landlord hereby covenants that Tenant, upon paying rent as herein reserved, and
performing all covenants and agreements herein contained on the part of Tenant, shall and may peacefully and quietly have, hold and enjoy the Premises without any disturbance from Landlord or from any other person claiming by, through or under
Landlord, subject to the terms, provisions, covenants, agreements and conditions of this Lease, specifically including, but without limitation, the matters described in Paragraph 34 hereof. 

28. Severability. If any clause or provision of this Lease is illegal, invalid or unenforceable under present or
future laws effective during the Lease Term, then and in that event, it is the intention of the parties hereto that the remainder of this Lease shall not be affected thereby, and it is also the intention of the parties to this Lease that in lieu of
each clause or provision that is illegal, invalid or unenforceable, there be added as a part of this Lease a clause or provision as similar in terms to such illegal, invalid or unenforceable clause or provision as may be possible and be legal, valid
and enforceable. 
 29. Security Deposit. The Security Deposit shall be held by Landlord without liability for
interest and as security for the performance by Tenant of Tenant’s covenants and obligations under this Lease, it being expressly understood that the Security Deposit shall not be considered an advance payment of Rental or a measure of
Landlord’s damages in case of default by Tenant upon the occurrence of any Event of Default by Tenant or upon termination of this Lease. Landlord may commingle the Security Deposit with other funds. Landlord may, from time to time, without
prejudice to any other remedy, use the Security Deposit to the extent necessary to make good any arrearages of rent or to satisfy any other covenant or obligation of Tenant hereunder. Following any such application of the Security Deposit, Tenant
shall pay to Landlord on demand the amount so applied in order to restore the Security Deposit to its original amount. If Tenant is not in default at the termination of this Lease, the balance of the Security Deposit remaining after any such
application shall be returned by Landlord to Tenant within 60 days after the termination of this Lease. If Landlord transfers its interest in the Premises during the Lease Term, Landlord may assign the Security Deposit to the transferee and
thereafter shall have no further liability for the return of, or any other matter relating to, such Security Deposit. 

30. Insurance Requirements. 

(a) Tenant hereby waives any cause of action it might have against Landlord on account of any loss or damage
that is insured against under any insurance policy that covers the Premises, Tenant’s fixtures, personal property, leasehold improvements or business and which names Tenant as a party insured. Landlord hereby waives any cause of action it might
have against Tenant because of any loss or damage that is insured against under any insurance policy that covers the Building, business income or any property of Landlord used in connection with the Building and which names Landlord as a party
insured, provided that if the cost of restoring the loss or damage exceeds the amount of property damage insurance proceeds paid to Landlord on account of the loss or damage, Tenant shall remain liable to Landlord for the amount of such excess, to
the extent attributable to Tenant’s negligence or willful misconduct. This provision is cumulative of Paragraph 15. 

(b) Tenant, at its sole cost and expense, shall procure and maintain throughout the Lease Term: 

(i) a policy or policies for commercial general liability and property damage insurance on an occurrence basis,
with a broad form contractual liability endorsement (“Liability Insurance”) insuring Tenant against any and all liability for injury to or death of a person or persons and/or property damage, occasioned by or arising out of or in
connection with the use or occupancy of the Premises, the minimum amounts of liability of such policy or policies to be a combined single limit for each occurrence in an amount of not less than $2,000,000.00 per occurrence and in an amount of not
less than $3,000,000.00 general aggregate; provided, however, that Landlord shall retain the right to require Tenant to increase such coverage from time to time to that amount of insurance which in Landlord’s reasonable judgment is then being
customarily required by landlords for similar space in buildings comparable to the Building; 

  
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 (ii) Insurance against loss or damage by fire, and such other
risks and hazards as are insurable under then available standard forms of “Special Form Causes of Loss” or “Broad Form” (or its equivalent if not available) property insurance policies with extended coverage, insuring
Tenant’s Alterations and personal property at the Premises in an amount equal to 90% of the replacement value (or in such higher percentage as may be necessary to avoid application of coinsurance provisions of the policy) (“Hazard
Insurance”), as Landlord shall in no event be required to rebuild, repair or replace any part of the furniture, equipment, personal property, fixtures and other improvements which may have been placed by Tenant on or within the Premises;

 (iii) Business interruption insurance in an amount equal to at least one year’s rent; 

(iv) during the performance of any Alteration, until completion thereof, Builder’s Risk insurance
(“Alterations Insurance”) on an “all risk” basis and on a completed value form including Permission to Complete and Occupancy endorsement, for full replacement value covering the interest of Landlord and Tenant (and their
respective contractors and subcontractors) in all work incorporated in the Building and all materials and equipment in or about the Premises; 

(v) Workers’ Compensation Insurance, as required by law; 

(vi) Such other insurance in such amounts as the Landlord Parties may reasonably require. 

Landlord, Landlord’s managing agent, and any ground lessors and any mortgagees (whose names shall, from time to time, be
furnished to Tenant) (collectively, hereinafter referred to as “Landlord Parties”) shall be added as a loss payee as their respective interests may appear, to Tenant’s Hazard Insurance and Alterations Insurance, and shall also
be added as additional insureds on Tenant’s Liability Insurance, other than any worker’s compensation insurance. Tenant’s Liability Insurance shall include a contractual liability policy provision under which the insurer agrees to
indemnify, defend and hold the additional insureds harmless from and against, subject to the limits of liability required by this Lease and to the limitations applicable to contractual liability policies, all cost, expense and liability arising out
of, or based upon, any and all claims, accidents, injuries and damages for which Tenant is required to indemnify Landlord under this Lease. All Tenant’s insurance shall be primary and non-contributory (as shown on endorsement) and Tenant shall
obtain a written obligation on the part of each insurance company to notify the Landlord Parties at least ten (10) days prior to cancellation, expiration or material alteration of such insurance. In addition, upon receipt by Tenant of any
notice of cancellation or any other notice from the insurance carrier that may materially adversely affect the coverage of the insureds under such policy of insurance, Tenant shall promptly deliver to all Landlord Parties a copy of such notice. All
Tenant’s Insurance shall be effective under valid and enforceable policies issued by reputable and independent insurers authorized to do business in the State of Texas, and rated in Best’s Insurance Guide, or any successor thereto (or if
there be none, a similar organization having a national reputation) as having a general policyholder rating of “A-” and a financial rating of at least “IX.” 

(c) On or prior to the Commencement Date, Tenant shall deliver to Landlord appropriate policies or certificates
of insurance, including evidence of waivers of subrogation required to be carried pursuant to this Article and that the Landlord Parties are named as additional insureds and/or loss payees, as the case may be. Evidence of each renewal or replacement
of the insurance policies shall be delivered by Tenant to Landlord at least ten days prior to the expiration of such policies. 

  
 15 

 31. Binding Effect. The provisions of this Lease shall be binding
upon and inure to the benefit of Landlord and Tenant, respectively, and to their respective heirs, personal representatives, successors and assigns, subject to the provisions of Paragraphs 11, 24 and 41 hereof. 

32. Notices. Any notice required or permitted to be given hereunder by one party to the other shall be deemed to
be given when deposited in the United States mail, certified or registered, return receipt requested, with sufficient postage prepaid, or by a national recognized overnight courier, or hand delivered (against a signed receipt), addressed to the
respective party to whom notice is intended to be given at the address of such party set forth on the Basic Lease Information. Either party hereto may at any time by giving written notice to the other party in the aforesaid manner designate any
other address, which, in regard to notices to be given to Tenant, must be within the continental United States, in substitution of the foregoing address to which any such notice shall be given. 

33. Brokerage. Tenant warrants that it has not had any dealings with any broker or agent representing Tenant: in
connection with the negotiation or execution of this Lease other than Steven R. Biegel of Savills Studley, and Tenant agrees to indemnify Landlord and hold Landlord harmless from and against any and all cost, expense or liability for commissions or
other compensation or charges claimed by any other broker or agent purporting to have represented Tenant with respect to this Lease The provisions of this Section shall survive the expiration or earlier termination of this Lease. 

34. Subordination. This Lease and all rights of Tenant hereunder are subject and subordinate to any deed of
trust, mortgage or other instrument of security which does now or may hereafter cover the Building and the Land or any interest of Landlord therein, and to any and all advances made on the security thereof, and to any and all increases, renewals,
modifications, consolidations, replacements and extensions of any of such deed of trust, mortgage or instrument of security (collectively, “Mortgage”), and to all ground or underlying leases of the Real Property or the Building and
all renewals, extensions, supplements, amendments and modifications of those leases (collectively, “Ground Lease”). This provision is hereby declared by Landlord and Tenant to be self-operative and no further instrument shall be
required to effect such subordination of this Lease. Tenant shall, however, upon demand at any time or times execute, acknowledge and deliver to Landlord any and all instruments and certificates that, in the judgment of Landlord, may be necessary or
proper to confirm or evidence such subordination, and Tenant hereby irrevocably appoints Landlord as Tenant’s agent and attorney-in-fact for the purpose of executing, acknowledging and delivering any such instruments and certificates. However,
notwithstanding the generality of the foregoing provisions of this Paragraph 34, Tenant agrees that any mortgagee or ground lessee shall have the right at any time to subordinate any such Mortgage or Ground Lease, as the case may be, to this Lease
on such terms and subject to such conditions as such mortgagee or ground lessee may deem appropriate in its discretion. Tenant further covenants and agrees upon demand by Landlord’s mortgagee or ground lessor at any time, before or after the
institution of any proceedings for the foreclosure of any such Mortgage, or sale of the Building pursuant to any such Mortgage or voluntary sale, or termination of the Ground Lease, as the case may be, to attorn to the purchaser or owner upon any
such sale and to recognize and attorn to such purchaser or owner as Landlord under this Lease. The agreement of Tenant to attorn upon demand of Landlord’s mortgagee or ground lessor contained in the immediately preceding sentence shall survive
any such foreclosure sale or trustee’s sale or termination of a Ground Lease. Tenant hereby agrees to execute, acknowledge and deliver to Landlord’s mortgagee or ground lessor any and all instruments and certificates that Landlord’s
mortgagee or ground lessor may request in order to confirm or evidence such attornment. 
 35. Joint and Several
Liability. If there is more than one Tenant, the obligations hereunder imposed upon Tenant shall be joint and several. If there is a guarantor(s) of Tenant’s obligations hereunder, the obligations of Tenant shall be joint and several
obligations of Tenant and each such guarantor, and Landlord need not first proceed against Tenant hereunder before proceeding against each such guarantor, nor shall any such guarantor be released from its guarantee for any reason whatsoever,
including, without limitation, any amendment of this Lease, any forbearance by Landlord or waiver of any of Landlord’s rights, the failure to give Tenant or any such guarantor any notices, or the release of any party liable for the payment or
performance of any of Tenant’s obligations hereunder. 
 36. Building Name and Address. Landlord reserves
the right at any time to change the name by which the Building is designated and its address, and Landlord shall have no obligation or liability whatsoever for costs or expenses incurred by Tenant as a result of such name change or address change of
the Building. 

  
 16 

 37. Estoppel Certificates; Financial Statements. 

(a) Tenant agrees to furnish from time to time, within five (5) days following the written request by
Landlord or any successor to Landlord or by the holder of any deed of trust or mortgage covering the Land and Building or any interest of Landlord therein, an estoppel certificate signed by Tenant to the effect that this Lease is then presently in
full force and effect and specifying any modifications; that the Lease Term has commenced and the full Rental is then accruing hereunder; that Tenant has accepted possession of the Premises and that any improvements required by the terms of this
Lease to be made by Landlord have been completed to the satisfaction of Tenant; that no rent under this Lease has been paid more than thirty (30) days in advance of its due date; that the address for notices to be sent to Tenant is as set forth
in this Lease; that Tenant, as of the date of such certificate, has no charge, lien or claim of offset under this Lease or otherwise against rents or other charges due or to become due hereunder; and that to the knowledge of Tenant, Landlord is not
then in default under this Lease. To the extent that Tenant believes any of the foregoing to be inaccurate, Tenant shall specifically enumerate in the certificate the alleged inaccuracy and Tenant’s basis for refusing to certify to such facts.
At Landlord’s option, any such certificate may also contain an acknowledgment by Tenant of receipt of notice of the assignment of this Lease to such holder and the agreement by Tenant with such holder that from and after the date of such
certificate, Tenant will not pay any rent under this Lease more than thirty (30) days in advance of its due date, will not surrender or consent to the modification of any of the terms of this Lease nor to the termination of this Lease by
Landlord, and will not seek to terminate this Lease by reason of any act or omission of Landlord until Tenant shall have given written notice of such act or omission to the holder of such deed of trust or mortgage (at such holder’s last address
furnished to Tenant) and until a reasonable period of time shall have elapsed following the giving of such notice, during which period such holder shall have the right, but shall not be obligated, to remedy such act or omission; provided, however,
that (i) the agreement of Tenant described in this sentence will be of no effect under such certificate unless Tenant is furnished by such holder with a copy of any assignment to such holder of Landlord’s interest in this Lease within
ninety (90) days after the date of such certificate, and (ii) the agreement of Tenant with such holder that is embodied in such certificate shall terminate upon the subsequent termination of any such assignment. In the event Tenant shall
fail or neglect to execute, acknowledge and deliver any such certificate, Landlord may, as the agent and attorney-in-fact of Tenant, execute, acknowledge and deliver the same, and Tenant hereby irrevocably nominates, constitutes and appoints
Landlord as Tenant’s proper and legal agent and attorney-in-fact for such purpose. Such power of attorney shall not terminate on disability of the principal. 

(b) Tenant shall also furnish to Landlord when requested by Landlord, but no more often than one time per
calendar year, a statement of the financial condition of Tenant prepared by an independent certified public accountant in a form reasonably satisfactory to Landlord. 

38. Mechanic’s Liens. Nothing contained in this Lease shall authorize Tenant to do any act which shall in
any way encumber the title of Landlord in and to the Premises or the Building or any part thereof; and if any mechanic’s or materialman’s lien is filed or claimed against the Premises or Building or any part thereof in connection with any
work performed, materials furnished or obligation incurred by or at the request of Tenant, Tenant will promptly pay same or cause it to be released of record or bonded around in accordance with applicable law. If the lien is not released of record
within or bonded around, or default in payment thereof shall continue for, twenty (20) days after written notice thereof from Landlord to Tenant, without limiting or otherwise affecting any of Landlord’s other rights or remedies and
without waiving any Event of Default by Tenant, Landlord shall have the right and privilege at Landlord’s option of paying the same or any portion thereof without inquiry as to the validity thereof, and any amounts so paid, including expenses
and interest at the Default Rate, shall be so much Additional Rent hereunder from Tenant to Landlord and shall be repaid to Landlord immediately on demand therefor. 

39. Taxes and Tenant’s Property. Tenant shall be liable for all taxes levied or assessed against personal
property, furniture or fixtures placed by Tenant in the Premises. If any such taxes for which Tenant is liable are levied or assessed against Landlord or Landlord’s property and if Landlord elects to pay the same or if the assessed value of
Landlord’s property is increased by inclusion of personal property, furniture or fixtures placed by Tenant in the Premises, and Landlord elects to pay the taxes based on such increase, Tenant shall pay Landlord upon demand that part of such
taxes for which Tenant is primarily liable hereunder. 
 40. Constructive Eviction. Tenant shall not be
entitled to claim a constructive eviction from the Premises unless Tenant shall have first notified Landlord in writing of the condition or conditions giving rise thereto, and, if the complaints be justified, unless Landlord shall have failed to
remedy such conditions within a reasonable lime after receipt of said notice. 

  
 17 

 41. Landlord’s Liability. The liability of Landlord to Tenant
for any default by Landlord under the terms of this Lease shall be limited to Tenant’s actual direct, but not consequential, damages therefor and shall be recoverable from the interest of Landlord in the Building and the Land, and Landlord
shall not be personally liable for any deficiency. This clause shall not be deemed to limit or deny any remedies which Tenant may have in the event of default by Landlord hereunder which do not involve the personal liability of Landlord.
Notwithstanding anything to the contrary contained in this Lease, in the event Landlord sells, assigns, transfers or conveys its interest in the Building and the Land, Landlord shall have no liability for any acts or omissions that occur after the
date of said sale, assignment, transfer or conveyance. 
 42. Execution by Landlord. The submission of this
Lease to Tenant shall not be construed as an offer, and Tenant shall not have any rights with respect hereto unless and until Landlord shall, or shall cause its managing agent to, execute a copy of this Lease already executed and delivered by Tenant
to Landlord, and deliver the same to Tenant. 
 43. No Waiver. No waiver by Landlord of any of its rights or
remedies hereunder, or otherwise, shall be considered a waiver of any other or subsequent right or remedy of Landlord; no delay or omission in the exercise or enforcement by Landlord of any rights or remedies shall ever by construed as a waiver of
any right or remedy of Landlord; and no exercise or enforcement of any such rights or remedies shall ever be held to exhaust any right or remedy of Landlord. 

44. No Third Party Beneficiary. This Lease is for the sole benefit of Landlord, its successors and assigns, and
Tenant, its permitted successors and assigns, and it is not for the benefit of any third party. 
 45. Number and
Gender. Words of any gender used in this Lease shall be held and construed to include any other gender, and words in the singular number shall be held to include the plural, unless the context otherwise requires. 

46. Force Majeure. Whenever a period of time is herein prescribed for action to be taken by Landlord, Landlord
shall not be liable or responsible for, and there shall be excluded from the computation for any such period of time, any delays due to strikes, riots, acts of God, shortages and/or unavailability of labor or materials, war, governmental laws,
regulations or restrictions, or any other cause of any kind whatsoever which are beyond the reasonable control of Landlord. 

47. Environmental Compliance. Tenant covenants and agrees to comply strictly and in all respects with the
requirements of any applicable law, statute, ordinance, permit, decree, guideline, rule, regulation or order pertaining to health or the environment (hereinafter sometimes collectively called “Applicable Environmental Laws”),
including, without limitation, the Comprehensive Environmental Response, Compensation, and Liability Act of 1980, the Resource Conservation and Recovery Act, the Texas Water Code and the Texas Solid Waste Disposal Act, as each of the foregoing may
be amended, supplemented or replaced from time to time. Except in connection with Tenant’s Permitted Use under this Lease (which Tenant shall do in strict conformity with all Applicable Environmental Laws and all other applicable laws,
ordinances, orders, rules and regulations), Tenant shall not cause or permit any Hazardous Materials (as hereinafter defined) to be generated, treated, stored, used, installed or disposed in, on, under or about the Premises or the Building. Tenant
shall procure, maintain in effect, and comply with all conditions of any and all permits, licenses and other government and regulatory approvals required for the storage or use by Tenant of Hazardous Materials on the Premises, including without
limitation, discharge of properly treated materials or waste into or through any sanitary sewer serving the Premises. Tenant represents, warrants, covenants and agrees that Tenant is not and will not become involved in operations at the Premises or
Building which could lead to the imposition on Landlord or its agents, officers and directors (herein “Landlord’s Related Parties”) of liability under any of the Applicable Environmental Laws. Tenant does hereby, for itself and
on behalf of its agents, invitees, officers and directors (herein “Tenant’s Related Parties”), agree to and hereby does INDEMNIFY, DEFEND and HOLD HARMLESS Landlord and Landlord’s Related Parties, of, from and against any and all
liabilities, assessments, suits, damages, fees, claims, fines, penalties, deficiencies, losses, suits, actions, causes of action, costs, expenses, Legal Costs, judgments and amounts paid in settlement at any time, in any way related to, or in any
way arising out of (i) the breach of any of the covenants, conditions or agreements of Tenant or any of Tenant’s Related Parties under this Paragraph 47, (ii) the handling, installation, storage, use, generation, treatment or disposal
of Hazardous Materials, including any cleanup, remedial, removal, or restoration 

  
 18 

 
work required by the Applicable Environmental Laws or (iii) the assertion of any lien or claim imposed against the Premises, Building, Building or any portion thereof or Landlord or any of
Landlord’s Related Parties, or any of their respective property, pursuant to the Applicable Environmental Laws. The covenants, indemnities and agreements of Tenant under this Paragraph 47 shall survive the expiration or termination of this
Lease. 
 Tenant, at Tenant’s sole cost and expense, shall maintain, throughout the Lease Term, a contract with a
licensed medical waste removal company reasonably approved by Landlord for the removal and disposal of all Medical Waste, contaminated waste and Hazardous Substances. Tenant shall store within the Premises, and shall arrange for the timely removal
and disposal of, all Medical Waste, contaminated waste and Hazardous Substances in accordance with all applicable Requirements. Tenant shall not permit the mixing, disposal, or release of any Medical Waste into general office trash, waste or refuse
and shall separate Medical Waste from other types of refuse and shall place the Medical Waste in an air-tight locked covered container conspicuously marked with the phrase “Medical Waste” and the skull and cross bones warning for toxic
substances. Such container shall be impervious to the elements, air-tight, and puncture resistant. At Landlord’s request, Tenant shall deliver to Landlord documentary proof that Tenant is in compliance with this provision. Any fines incurred by
Landlord by reason of Tenant’s failure to comply with the provisions of this subsection shall be paid by Tenant to Landlord on demand as Additional Rent. 

As used in this Lease, the term “Hazardous Materials” means any nuclear materials, nuclear waste, medical
materials, Medical Waste, flammables, explosives, radioactive materials, radioactive waste, asbestos-containing materials, the group of organic compounds known as polychlorinated byphenyls and other hazardous waste, toxic substances or related
materials, including without limitation substances defined as “hazardous substances”, “hazardous materials”, “toxic substances” or “solid waste” in the Comprehensive Environmental Response, Compensation, and
Liability Act of 1980, the Hazardous Materials Transportation Act, the Resource Conservation and Recovery Act, and the Texas Solid Waste Disposal Act, as each of the foregoing may be amended, supplemented or replaced from time to time. 

48. APPLICABLE LAW; CONSENT TO JURISDICTION. THIS LEASE SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE
LAWS OF THE STATE OF TEXAS AND THE LAWS OF THE UNITED STATES APPLICABLE TO TRANSACTIONS IN THE STATE OF TEXAS. TENANT HEREBY IRREVOCABLY AGREES THAT ANY LEGAL ACTION OR PROCEEDING AGAINST IT WITH RESPECT TO THIS LEASE MAY BE MAINTAINED IN THE COURTS
OF HARRIS COUNTY, TEXAS OR IN THE U.S. DISTRICT COURT FOR THE SOUTHERN DISTRICT OF TEXAS, AND TENANT HEREBY CONSENTS TO THE JURISDICTION AND VENUE OF SUCH COURTS. 

IN WITNESS WHEREOF, this Lease Agreement is entered into by the parties hereto on the day and year first set forth
above. 
  

			
	 LANDLORD:

	 GREENPARK II MEDICAL LLC,

a Delaware limited liability company

		
	 By:
		 /s/ Norman Livingston

		 	  

			 Norman Livingston

			 Managing Member

	
	 TENANT:

	
	 ESSA PHARMACEUTICALS CORP.,

a Texas corporation

		
	 By:
		 /s/ Bob Rieder

		 	  

	 Title:
		 CEO

		 	  

  
 19 

 EXHIBIT “A” TO LEASE AGREEMENT 

Legal Description of the Land 

METES AND BOUNDS DESCRIPTION OF A 1.832 ACRE TRACT OF LAND OUT OF THE PLEASANT W. ROSE SURVEY, ABSTRACT 645 HARRIS COUNTY, TEXAS 

Being a tract of land containing 1.832 acres out of the Pleasant W. Rose Survey, Abstract 645, in Harris County, Texas, and part of a 7.240
acre tract of land recorded in Harris County Clerk’s Pile No. H-351965. Said 1.832 acres being more particularly described by metes and bounds as follows: 

COMMENCING at a 5/8-inch iron rod, marking the intersection of the Southeast right-of-way line of the South Main Street (based on a width of
120.00 feet) and the Southwest right-of-way line of Greenbriar Drive (based on a width of 60.00 feet), same being the Northwesterly corner of Block Nine (9), of the replat of Braeswood Addition, Section “1A”, recorded in Volume 12, Page
24, of the Harris County Map Records; 
 THENCE South 35’00’00” West with the Southeast right-of-way line of South Main
Street, 612.50 feet to a point for corner and being the PLACE OF BEGINNING for the tract of land herein described; 
 THENCE South
55’04’34” East, 255.22 feet to a point for corner; 
 THENCE North 34’55’26” East, 15.00 feet to a point for
corner; 
 THENCE South 55’04’34” East, 44.00 feet to a point for corner; 

THENCE South 34’55’26” West, 15.00 feet to a point for corner; 

THENCE South 55’04’34” East, 73.45 feet to a point for corner; same being on the Northwest right-of-way line of Brays Bayou;

 THENCE along said Northwest right-of-way line the arc of a curve to the right, having a chord of South 32’59’28” West
208.35 feet, a radius of 570.44 feet, a central angle of 21’02’44”, a distance of 209.53 feet to a 5/8-inch iron rod for corner; 

THENCE North 55’00’00” West, 324.97 feet to a 5/8-inch iron rod for corner; 

THENCE North 25’56’43” West, 20.59 feet to a 5/8-inch iron rod for corner; 

THENCE North 55’00’00” West, 37.00 feet to a 5/8-inch iron rod for corner; same being on the Southeast right-of-way line of the
aforementioned South Main Street; 
 THENCE North 35’00’00” East, along said Southeast right-of-way line, 197.73 feet to the
PLACE OF BEGINNING, containing 1.832 acres of land, more or less. 

  

					
			  
  

EXHIBIT “A” - PAGE 1 OF 1
		

 EXHIBIT “B” TO LEASE AGREEMENT 

[Floor Plan to be provided] 
  

 

  

					
			  
  

EXHIBIT “B” - PAGE 1 OF 1
		

 EXHIBIT “C” TO LEASE AGREEMENT 

Holidays 
  

			
	 January 1st*
		 New Year’s Day

		
	 Last Monday in May
		 Memorial Day

		
	 July 4th*
		 Independence Day

		
	 First Monday in September
		 Labor Day

		
	 Fourth Thursday in November plus Friday following
		 Thanksgiving Holidays

		
	 December 25th*
		 Christmas Day

  

	*	 or the day legally celebrated 

  

					
			  
  

EXHIBIT “C” - PAGE 1 OF 1
		

 EXHIBIT “D” TO LEASE AGREEMENT 

Leasehold Improvements Agreement 

This Leasehold Improvements Agreement (this “Agreement”) is made and entered into this
     day of August, 2014, in connection with that certain Lease Agreement (the “Lease”), executed concurrently herewith by and between GREENPARK II MEDICAL LLC (“Landlord”) and ESSA
PHARMACEUTICALS CORP. (“Tenant”), and constitutes the entire agreement of Landlord and Tenant with respect to the construction and completion of the Premises described in the Lease. In the event of a conflict between the provisions
of this Agreement and other provisions of the Lease, the provisions of this Agreement will control. Terms defined in the Lease, when used herein, shall have the same meanings as are ascribed to them in the Lease. 

1. Premises Condition. Since the Premises have been occupied by a previous tenant, Tenant hereby agrees to
accept the Premises in its “as is” condition, except that Landlord, at Landlord’s sole cost and expense will perform the following work: New paint, carpet, VCT and base selected by Tenant from Landlord’s building standard
materials; New 2x2 building standard ceiling tile, utilizing the existing ceiling grid; Remove the one-way glass between the conference room and adjacent small room and replace with solid drywall; Replace the toilet and sink in the private bath
within the Premises with building standard fixtures; Install building standard window film selected by Tenant at the entry and within the Premises on glass partitions designated by Tenant, and; and Install building standard vinyl graphics on
Tenant’s suite sign (collectively, “Landlord’s Work”). 
 2. Occupancy of the Premises.
The Lease Term and Tenant’s Rent obligations under the Lease will commence upon the Commencement Date set forth in the Lease except as otherwise expressly provided herein or in the Lease. Subject to any delays that are the responsibility of
Tenant, Landlord shall cause all of the Work to be substantially completed on or before the Commencement Date set forth in the Lease, subject to Tenant’s Delays, delays caused by force majeure and subject to the provisions of Paragraph 8 of the
Lease. Tenant agrees that upon substantial completion of the Work, Tenant will occupy and accept the Premises, subject to any incomplete or defective work described on a punch list prepared by Landlord and approved by Tenant prior to occupancy. Only
one punch list will be prepared prior to Tenant’s occupancy of the Premises. Latent defects or other items mutually agreed upon between Landlord and Tenant not listed in the original punch list may be added to such original punch list for a
period of thirty (30) days after Tenant’s occupancy of the Premises. Tenant shall not enter into possession of the Premises prior to substantial completion without Landlord’s written consent, which consent may be granted or withheld
at the sole discretion of Landlord. In the event Tenant takes possession of all or any portion of the Premises with Landlord’s consent prior to substantial completion of the Premises, without limitation, of Landlord’s other rights and
remedies, Tenant agrees to indemnify Landlord and hold Landlord harmless from and against any and all loss, cost, expense, damage, claim, action and liability that Landlord may ever suffer or incur or have asserted against it on account of any loss
of or damage to property (whether owned by Landlord, Tenant or any third party) or injury or death of any person that occurs prior to the date of substantial completion, whether due to the negligence of Landlord or Tenant, or their respective
employees, agents or contractors. 
 EXECUTED as of the day and year first above written. 

 

			
	 LANDLORD:

	
	 GREENPARK II MEDICAL LLC,

a Delaware limited liability company

		
	 By:
		 /s/ Norman Livingston

		 	  

			 Norman Livingston

			 Manager

	
	 TENANT:

	
	 Essa Pharmaceuticals Corp.

	
	/s/ Bob Rieder
	  

		
	 By:
		 Bob Rieder

		 	  

	 Title:
		 CEO

		 	  

  

					
			  
  

EXHIBIT “D” - PAGE 1 OF 1
		

 EXHIBIT “E” TO LEASE AGREEMENT 

Acceptance of Premises Memorandum 

THIS ACCEPTANCE OF PREMISES MEMORANDUM (this “Memorandum”) is entered into on this
     day of             , 20     by and between GREENPARK II MEDICAL LLC, a Delaware limited liability company, as Landlord
(“Landlord”), and                     , as Tenant (“Tenant”). Unless otherwise defined herein, all capitalized
terms used herein shall have the same meaning ascribed to such terms in the Lease (as hereinafter defined). 
 R E C I T A L S:

 WHEREAS, on             ,
20    , Landlord and Tenant entered into that certain Lease Agreement (the “Lease”) whereby Landlord leased certain Premises located in the Building to Tenant pursuant to certain terms and provisions more
particularly described therein; 
 WHEREAS, certain leasehold improvements to the Premises have been constructed and
installed for the benefit of Tenant in accordance with the Approved Working Drawings and upon the terms and conditions set forth in the Leasehold Improvements Agreement attached as Exhibit “D” to the Lease; and 

WHEREAS, as provided in Paragraph 8 of the Lease, Tenant desires to take possession of and accept the Premises subject
to the terms and provisions hereof. 
 NOW, THEREFORE, for and in consideration of the premises, and the mutual
covenants and agreements contained herein and in the Lease, Landlord and Tenant hereby expressly covenant, acknowledge and agree as follows: 

1. Except for the specific items described in the “punch list” attached hereto as Exhibit “E-1” and
incorporated herein by reference for all purposes, which Landlord shall endeavor to remedy within                      (    )
business days hereof, Landlord has fully completed the Alterations to the Premises in accordance with the Approved Working Drawings and approved Change Orders, if any, and pursuant to the Leasehold Improvements Agreement. The Premises are
substantially complete as that term is defined in Paragraph 8 of the Leasehold Improvements Agreement attached as Exhibit “D” to the Lease. 

2. The Premises are tenantable and ready for immediate occupancy by Tenant, Landlord has no further obligation to
install or construct any leasehold improvements, modifications or alterations to the Premises (except as described in Exhibit “E-1” attached hereto), and, except as described in Exhibit “E-1” attached hereto, the Premises are
satisfactory to Tenant in all respects. 
 3. The Commencement Date shall be
            , 20    . Pursuant to the provisions of the Lease, the first monthly installment of Base Rental shall become due and payable on
            , 20    . 
 4. The
Expiration Date shall be             , 20    . 

5. Except as specifically set forth herein, as of the date of this Memorandum, the Lease has not been modified,
altered, supplemented, superseded or amended in any respect. 
 6. All terms, provisions and conditions of the Lease
are and remain in full force and effect, and are hereby expressly ratified, confirmed, restated and reaffirmed in each and every respect. 

IN WITNESS WHEREOF, this Memorandum is entered into by Landlord and Tenant on the date first set forth above. 

  

					
			  
  

EXHIBIT “E” - PAGE 1 OF 1
		

									
					
			
	 LANDLORD:
				 TENANT:

			
	 GREENPARK II MEDICAL LLC,

a Delaware limited liability company
				 Essa Pharmaceuticals Corp.

				
			 /s/ Norman Livingston
				 /s/ Bob Rieder

		 	 		 	  

	 By:
					 By:
		 Bob Rieder

		 	  
	 		 		 	  

			 Norman Livingston
				 Its:
		 CEO

		 		 		 		 	  

			 Manager
						
									

  

					
			  
  

EXHIBIT “E” - PAGE 1 OF 1
		

 EXHIBIT “F” TO LEASE AGREEMENT 

Building Rules and Regulations 

1. Sidewalks, doorways, vestibules, corridors, stairways and other similar areas shall not be obstructed by Tenant or
used by Tenant for any purpose other than ingress and egress to and from the Premises and for going from or to another part of the Building. 

2. Plumbing fixtures and appliances shall be used only for the purposes for which designed, and no sweepings, rubbish,
rags or other unsuitable materials shall be thrown or placed therein. Damage resulting to any such fixtures or appliances or surrounding areas from misuse by Tenant shall be repaired at the sole cost and expense of Tenant, and Landlord shall not in
any case be responsible therefor. 
 3. No signs, advertisements or notices shall be painted or affixed on or to any
windows or doors or other parts of the Building except of such color, size and style and in such places as shall be first approved in writing by Landlord. No nails, hooks or screws shall be driven or inserted in any part of the Building except by
the Building maintenance personnel nor shall any part of the Building be defaced by Tenant. 
 4. Landlord will
provide and maintain an alphabetical directory of each Tenant’s firm name on the first floor (main lobby) of the Building and no other directory shall be permitted unless previously consented to by Landlord in writing. 

5. Tenant shall not place any additional lock or locks on any doors in or to the Premises without Landlord’s prior
written consent. Two keys to the locks on the doors which access the Premises from the Common Areas shall be furnished by Landlord to Tenant, and Tenant shall not have any duplicate keys made. Additional keys required by Tenant shall be made by
Landlord at Tenant’s sole expense. Upon termination of the Lease, Tenant shall return all keys to Landlord and shall provide to Landlord a means of opening all safes, cabinets and vaults being left with the Premises. 

6. With respect to work being performed by Tenant in the Premises with the approval of Landlord, Tenant will refer all
contractors, contractor’s representatives and installation technicians rendering any service to them to Landlord for Landlord’s supervision, approval and control before the performance of any contractual services. This provision shall
apply to work performed in the Building including, but not limited to, installation of telephones, communication equipment, electrical devices and attachments, and any and all installation of every nature affecting floors, walls, woodwork, trim,
windows, ceilings, equipment and any other physical portion of the Building. Tenant must have Landlord’s written approval prior to employing any contractor. Any and all such contractors shall comply with these Rules and Regulations for such
services including, but not limited to, insurance requirements. All work in or on the Building shall comply with any and all codes. Tenant shall take no action which would disturb the ceiling tiles or cause any work to be performed above the
acoustical ceiling in the Building. 
 7. Movement in or out of the Building of furniture or office equipment, or
dispatch or receipt by Tenant of any bulky materials, merchandise or materials which require use of elevators or stairways, or movement through the Building entrances or lobby shall be restricted to such hours as Landlord shall designate. All such
movement shall be under the supervision of Landlord and in the manner agreed between Tenant and Landlord by prearrangement before performance. Such prearrangement initiated by Tenant will include determination by Landlord, and subject to its
decision and control, as to the time, method and routing of movement and as to limitations for safety or other concerns which may prohibit any article, equipment or any other item from being brought into the Building. Tenant is to assume all risk as
to damage to articles moved and injury to person or public engaged or not engaged in such movement, including equipment, property and personnel of Landlord and other tenants if damaged or injured as a result of acts in connection with carrying out
this service for Tenant from the time of entering the property to completion of work; and Landlord shall not be liable for acts of any person engaged in, or any damage or loss to any of said property or persons resulting from any act in connection
with such service performed for Tenant. 

  

					
			  
  

EXHIBIT “F” - PAGE 1 OF 3
		

 8. Landlord shall have the power to prescribe the weight and position of
safes and other heavy equipment, which shall, in all cases, be positioned to distribute the weight and stand on supporting devices approved by Landlord. All damage done to the Building by taking in or putting out any property of Tenant, or done by
Tenant’s property while in the Building, shall be repaired at the expense of Tenant. 
 9. Corridor doors, when
not in use, shall be kept closed. 
 10. Tenant shall cooperate with Landlord’s employees in keeping its
Premises neat and clean. Tenant shall not employ any person for the purpose of such cleaning other than the Building’s cleaning and maintenance personnel. Landlord shall be in no way responsible to Tenant, its agents, employees or invitees for
any loss of property from the Premises or public areas or for any damage to any property thereon from any cause whatsoever. 

11. To insure orderly operation of the Building, no ice, mineral or other water, towels, newspapers, etc. shall be
delivered to the Premises except by persons approved by Landlord in writing. 
 12. For Tenant required communication
service, Landlord will direct the electrician where and how wires are to be introduced and placed and none shall be introduced or placed except as Landlord shall direct. Electric current shall not be used for power in excess of standard office use,
cooking or heating without Landlord’s prior written permission. Heating or cooking shall not mean the brewing of coffee, tea or similar beverages nor the heating of prepared food in small microwave ovens. 

13. Tenant shall not make or permit any improper noises in the Building or otherwise interfere in any way with other
tenants or persons having business with them. 
 14. Nothing shall be swept or placed into the corridors, halls,
elevator shafts or stairways. No animals shall be brought into or kept in, on or about the Premises. 
 15. No
machinery other than standard medical office equipment shall be operated by Tenant in its Premises without the prior written consent of Landlord, nor shall Tenant use or keep in the Building any flammable or explosive fluid or substance. Business
machines and mechanical and electrical equipment belonging to Tenant which cause noise, vibration, electrical or magnetic interference, or any other nuisance that may be transmitted to the structure of other portions of the Building or the Premises
to such a degree as to be objectionable to Landlord or which interfere with the use or enjoyment by other tenants of their Premises or the Common Areas, shall be placed and maintained by Tenant, at Tenant’s expense, in settings of cork, rubber,
spring type, or other vibration-eliminating devices sufficient to eliminate noise and vibrations. 
 16. No portion
of the Premises shall at any time be used or occupied as sleeping or lodging quarters. 
 17. Landlord will not be
responsible for money, jewelry or other personal property lost or stolen in or from the Premises or public areas regardless of whether such loss or theft occurs when the area is locked against entry or not. 

18. The Premises shall not be occupied by an average of more than one (1) person per 150 rentable square feet of
the Premises without the prior written consent of Landlord. 
 19. Landlord reserves the right to rescind any of
these rules and regulations and to make such other and further rules and regulations as in its judgment shall from time to time be advisable for the safety, protection, care and cleanliness of the Building, the use and operation thereof, the
preservation of good order therein and the protection and comfort of the tenants and their agents, employees and invitees, which rules and regulations, when made and written notice thereof is given to Tenant, shall be binding upon Tenant in like
manner as if originally herein prescribed. 
 20. The requirements of Tenant will be attended to only upon
application at the office of Landlord in the Building or at such other address as may be designated by Landlord. Employees of Landlord shall not perform any work or do any of their regular duties, unless under special instructions from the office of
Landlord. 

  

					
			  
  

EXHIBIT “F” - PAGE 2 OF 3
		

 21. No awnings, draperies, shutters or other interior or exterior window
coverings that are visible from the exterior of the “Building or from the exterior of the Premises within the Building may be installed by Tenant without Landlord’s prior written consent. 

22. Canvassing, soliciting or peddling in the Building is prohibited and Tenant shall use commercially reasonable
efforts to prevent same. 
 23. Landlord shall have the right to exclude any person from the Building, and any person
in the Building will be subject to identification by employees and agents of Landlord. All persons in or entering the Building shall be required to comply with the security policies of the Building, including, without limitation, the showing of
suitable identification and signing of a Building register when entering or leaving the Building. If Tenant desires additional security service for the Premises, Tenant shall have the right (with advance written consent of Landlord) to obtain such
additional service at Tenant’s sole cost and expense. Notwithstanding the foregoing, Tenant acknowledges and agrees that Landlord shall not have any responsibility for providing security systems to protect Tenant’s PHI and the same shall
be preserved by Tenant in a secure cabinet, as to papers, and secure electronic format as to electronic files; that the PHI access points be clearly and conspicuously identified with restrictions such as “THESE CABINETS/COMPUTERS CONTAIN
PROTECTED AND CONFIDENTIAL INFORMATION. ANY UNAUTHORIZED ACCESS OR USE MAY RESULT IN VIOLATION OF FEDERAL LAW, FINES AND IMPRISONMENT”. Tenant shall keep doors to unattended areas locked and shall otherwise exercise reasonable precautions to
protect property from theft, loss or damage. Landlord shall not be responsible for the theft, loss or damage of any property or for any error with regard to the exclusion from or admission to the Building of any person. In case of an invasion, mob,
riot or public excitement, Landlord reserves the right to implement reasonable measures to limit, restrict or prevent access to the Building during the continuance of same. 

  

					
			  
  

EXHIBIT “F” - PAGE 3 OF 3
		

 Rider No. 100         

LEASE GUARANTY 

FOR VALUE RECEIVED, and in consideration of, and in order to induce GREENPARK II MEDICAL LLC
(“Landlord”) to execute a certain Lease Agreement (the “Lease”; all capitalized terms used herein shall have the meanings set forth in the Lease unless otherwise defined) dated of even date herewith between Landlord
and ESSA PHARMACEUTICALS CORP (“Tenant”) covering certain premises in Landlord’s office tower known as GREENPARK TWO MEDICAL PROFESSIONAL BUILDING situated in the City of Houston, Texas, the undersigned (hereinafter referred to
individually and collectively as “Guarantor” whether one or more) hereby jointly and severally guarantees unto Landlord (i) the full and prompt payment of the Base Rental, Additional Rent and all other sums and charges payable
by Tenant under the Lease, and (ii) the full and timely performance and observance of all the covenants, terms, conditions and agreements therein provided to be performed and observed by Tenant (the Base Rental, Additional Rent, other sums and
charges and other obligations, liabilities and duties described in the foregoing clauses (i) and (ii) being hereinafter collectively referred to as the “Obligations”). Guarantor hereby covenants that if Tenant shall
default in the payment or performance of any of the Obligations that continues beyond any applicable notice and/or grace period, Guarantor shall pay the amount due to Landlord and perform all of the other obligations with respect to which Tenant is
then in default. Guarantor further covenants to pay to Landlord on demand by Landlord all damages, costs and expenses that may arise in consequence of any default by Tenant or that are incurred in enforcing this Guaranty, including without
limitation, Legal Costs. 
 This Guaranty is an absolute and unconditional guaranty of payment and of performance. It shall
be enforceable against Guarantor without the necessity of (i) any suit instigated by Landlord against Tenant, (ii) the exhaustion of Landlord’s remedies with respect to Tenant under the Lease, or (iii) the enforcement of
Landlord’s rights with respect to any security which has ever been given to secure the payment and performance of the Obligations. This Guaranty shall also be enforceable without the necessity of any notice of Tenant’s nonpayment or
nonperformance, notice of acceptance of this Guaranty or any other notice or demand to which Guarantor might otherwise be entitled, all of which Guarantor hereby expressly waives. 

The obligations of Guarantor shall be irrevocable and unconditional, irrespective of the genuineness, validity, regularity or
enforceability of the Lease or any security given for the Obligations or any circumstance which might otherwise constitute a legal or equitable discharge of a surety or guarantor, and Guarantor waives the benefit of all principles or provisions of
law, statutory or otherwise, which are or might be in conflict with the terms of this Guaranty, and agrees that the obligations of Guarantor hereunder shall not be affected by any circumstances, whether or not referred to in this Guaranty, which
might otherwise constitute a legal or equitable discharge of a surety or guarantor. Specifically, Guarantor waives the benefits of any right of discharge under Chapter 34 of the Texas Business and Commerce Code and any other rights of sureties and
guarantors thereunder. Without limiting the generality of the foregoing, Guarantor agrees that the occurrence of the following events (or any thereof), whether they occur with or without notice or consent by Guarantor, will in no way release or
impair any liability or obligation of Guarantor hereunder: (i) Landlord, in its discretion, waives compliance by Tenant with any of its Obligations or covenants under the Lease or waives any default thereunder, or grants any indulgence with
respect to the Lease, (ii) Landlord modifies, amends or changes any provision of the Lease, (iii) Landlord grants extensions or renewals of the Lease or the Obligations, (iv) Landlord transfers its interest in the premises covered by
the Lease or its rights under this Guaranty, (v) Landlord consents to the assignment by Tenant of its rights under the Lease, (vi) Landlord deals in any respect with Tenant and the Obligations as if this Guaranty were not in effect,
(vii) Tenant is released from its Obligations by benefit of an exculpation clause in the Lease, (viii) the release or discharge of Tenant in an creditor’s proceedings, receivership, bankruptcy or other proceeding, (ix) the
impairment, limitation or modification of the liability of Tenant or the estate of Tenant in bankruptcy, or of any remedy for the enforcement of Tenant’s liability under the Lease, resulting from the operation of any present or future provision
of the federal Bankruptcy Act or other statute or from the decision in any court, and (x) the rejection or disaffirmance of the Lease in any such proceedings. If, as a result of such proceedings, Landlord is forced to refund any payment made by
Tenant to Landlord because it is found to be a preference or for any other reason, Guarantor hereby covenants to pay such amount to Landlord upon demand. 

All of Landlord’s rights and remedies under the Lease or under this Guaranty are intended to be distinct, separate and
cumulative, and no such right or remedy therein mentioned is intended to be in exclusion of or a waiver of any of the others. Specifically, the obligation of Guarantor hereunder shall not be released by Landlord’s receipt, application or
release of security given for performance and observance of covenants and conditions required to be performed and observed by Tenant under the Lease. 

  

					
			  
  

RIDER NO. 100 - PAGE 1 OF 2
		

 Until the Obligations have been paid in full, Guarantor shall not have any right
of subrogation unless such right is expressly granted in writing by Landlord. Any indebtedness of Tenant held by Guarantor is hereby subordinated to this Guaranty; and such indebtedness of Tenant to Guarantor, if Landlord so requests, shall be
collected, enforced and received by Guarantor as trustee for Landlord and shall be paid over to Landlord in order to satisfy the Obligations guaranteed hereunder. 

Landlord in its sole discretion may apply all payments received by it from Tenant, Guarantor or any other guarantor under any
other instrument, or realized by it from any security in such manner and order or priority as Landlord sees fit, to any of the Obligations of Tenant, whether or not any of the Obligations to which any payment is applied are due at the time of such
application. 
 Whether signed by only one person or more than one person, this Guaranty and all other obligations hereunder
shall be binding on each of the undersigned and their respective heirs, executors, administrators, successors and assigns. The word “person” as used herein includes natural persons and entities of all kinds. Suit may be brought and
maintained against Guarantor without the joinder of Tenant or any other person, and in the event that there is more than one guarantor of the Obligations, Landlord may (i) bring suit against all guarantors jointly and severally or against any
one or more of them, (ii) compound or settle with any one or more of such guarantors for such consideration as Landlord may deem proper, and (iii) release one or more of the guarantors from liability without impairing the liability of the
guarantors not so released; and no action brought by Landlord against any guarantor of the Obligations shall impair the right of Landlord to bring suit against any remaining guarantor or guarantors, including Guarantor hereunder. 

Guarantor agrees that if Landlord shall employ counsel to present, enforce or defend any or all of Landlord’s rights or
remedies hereunder, or defend any action brought by Guarantor, then, in any such event, Guarantor shall pay all Legal Costs incurred by Landlord in connection with any such action. 

This instrument may not be changed, modified, discharged or terminated orally or in any manner other than by an agreement in
writing signed by Guarantor and Landlord. 
 As used herein, the term “Tenant” shall include any successor or
assignee of Tenant, the term “Landlord” shall include any successor or assignee of Landlord, and the term “Lease” shall include any amendment, extension or renewal of the Lease. 

THIS GUARANTY SHALL BE CONSTRUED IN ACCORDANCE WITH AND GOVERNED BY THE LAWS OF THE STATE OF TEXAS AND THE LAWS OF THE
UNITED STATES APPLICABLE TO TRANSACTIONS IN THE STATE OF TEXAS. GUARANTOR HEREBY IRREVOCABLY AGREES THAT ANY LEGAL ACTION OR PROCEEDING AGAINST IT WITH RESPECT TO THIS GUARANTY MAY BE MAINTAINED IN THE COURTS OF HARRIS COUNTY, TEXAS, OR IN THE U.S.
DISTRICT COURT FOR THE SOUTHERN DISTRICT OF TEXAS AND GUARANTOR HEREBY CONSENTS TO THE JURISDICTION AND VENUE OF SUCH COURTS. GUARANTOR WAIVES AND RELINQUISHES ANY AND ALL RIGHTS UNDER TEXAS PROPERTY CODE SECTIONS 51.003, 51.004 AND 51.005. 

EXECUTED the 25 day of August, 2014. 

 

					
	/s/ Bob Rieder
	  

	 Name:
		 ESSA PHARMA INC.

	
	 Suite 720, 999 W. Broadway, Vancouver, BC, V5Z 1K5

	  

	 Address (Printed or Typed)

			
			 By:
		 Bob Rieder

			 Title:
		 CEO

		
	 By:
		 /s/ Norman Livingston

		 	  

			 (Signature)

  

					
			  
  

RIDER NO. 100 - PAGE 2 OF 2
		

 Rider No. 101 

PARKING FACILITIES 

At all times during the Lease Term and any renewal or extension thereof, and so long as this Lease and any renewal or
extension thereof is in full force and effect and no Event of Default shall have occurred and be continuing under this Lease, Tenant shall be permitted the use of the parking garage associated with the Building for parking automobiles owned by
Tenant and its employees, agents and invitees. Landlord hereby agrees to make available to Tenant, and Tenant hereby agrees to pay for and take, subject to the further provisions of this Rider No. 101, during the Lease Term, and any extension
or renewal thereof, all or some of the following permits to park automobiles in the parking garage: 
 Up to
one (1) permit for assigned and reserved parking stalls in the parking garage and up to nine (9) permits for unassigned and unreserved parking stalls in the parking garage. 

At least thirty (30) days prior to occupancy of the Premises by Tenant under this Lease, Tenant shall notify Landlord of
the exact number of parking permits which it will initially need, and Tenant shall thereafter pay for such permits at the rates provided hereinbelow in the manner established by Landlord or its garage operator from time to time. Whenever Tenant
desires to pay for and take additional parking permits to which it is entitled hereunder, but as to which Tenant has not heretofore notified Landlord it will need, Tenant shall give Landlord at least thirty (30) calendar days’ prior
written notice of the number of additional parking permits Tenant shall pay for and take and the date on which it will need such permits. Tenant’s right to such additional permits shall be subject to the availability of parking stalls in the
parking garage at the time the request is made, such determination of availability to be made by Landlord in Landlord’s sole discretion. Tenant shall not have the right to more parking permits than the number set forth above. All parking permit
payments shall be payable to Landlord, or if Landlord so desires, to the independent contractor which Landlord hires from time to time to operate the parking garage and/or uncovered parking areas. Except as set forth above, Tenant shall not be
assigned to designated parking stalls, but shall be permitted to use whatever unassigned and unreserved stalls are available, on a first-come, first-serve, unassigned and unreserved basis, in areas of the parking garage designated by Landlord.
Landlord reserves the right in its sole discretion to designate specific areas within the uncovered parking areas and/or the parking garage for the exclusive use of visitors and invitees to the Building and others. The designation of all such areas
shall be made by Landlord in its sole discretion, and Landlord reserves the right to change such designation from time to time. 

Landlord and its garage operator shall have the right from time to time to reconfigure the parking garage and to promulgate
reasonable rules and regulations regarding the parking permits available to Tenant hereunder and others, including, but not limited to, the flow of traffic to and from various parking areas, angles and direction of parking, and the like. Tenant
agrees to comply, and to cause its employees, agents and visitors to comply, with such rules and regulations (and reasonable additions and amendments thereto) as Landlord and its garage operator may promulgate from time to time. Landlord and its
garage operator will not be responsible for money, jewelry or other personal property lost or stolen in or from the parking garage, uncovered parking areas or public areas regardless of whether such loss or theft occurs when the garage or such area
is locked or otherwise secured against entry or not. Landlord reserves the right in connection with any redevelopment of the parking garage or Land to temporarily relocate Tenant’s parking to off-site parking areas in order for such parking
garage and/or Land to be redeveloped. 
 The payments to be made in connection with such parking permits shall be determined
from time to time by Landlord, in Landlord’s sole and absolute discretion, which payments shall be paid by Tenant to Landlord as Additional Rent. Pursuant to this Lease, the permit rates which are in effect as of the execution date hereof are
as follows: $75 per month plus tax for each permit for an unassigned and unreserved parking stall and $100 per month plus tax for each permit for an assigned and reserved parking stall. 

  

					
			  
  

RIDER NO. 101 - PAGE 1 OF 1
		

 Rider No. 102 

TENANT’S OPTION TO RENEW 

Tenant may, at its option and subject to the terms hereof, renew the Lease Term for one (1) additional term of twelve
(12) months, provided that this Lease must be in full force and effect and no Event of Default, or event or conditions which, with the giving of notice, the passage of time, or both, could mature into an Event of Default, may exist under this
Lease at the time of exercise of such option or at the time the renewal term would begin. Such renewal shall be upon the same terms and conditions of this Lease, including items of Additional Rent and the Base Expense Amount, except that
(i) this Lease may not be renewed more often than as set forth above, (ii) Landlord shall have no obligation to install any Alterations in the Premises or contribute to any Alterations, and (iii) the annual Base Rental for such
renewal period(s), and each monthly installment thereof, shall be determined as provided below. Each such option shall be exercised by Tenant giving notice (the “Renewal Notice”) to Landlord by certified mail, return receipt
requested, at least six months prior to the end of the then-existing term, and, if not so exercised, such option not so exercised and any subsequent option to renew shall automatically expire and terminate. Time is of the essence for Tenant’s
giving of the Renewal Notice. Notwithstanding anything to the contrary contained herein, Tenant’s option herein shall be subject to a determination by Landlord, at Landlord’s sole discretion, that Tenant’s financial condition at the
time it makes such election is comparable or better than the financial condition of Tenant at the time Tenant had executed the Lease. If Tenant so elects to renew the Lease Term, following Tenant’s exercise of such renewal option, upon request
from Landlord, Tenant and Landlord will enter into a renewal agreement by which this Lease will be renewed in accordance with the terms set forth in this Rider. 

The annual Base Rental for each renewal period shall be the “Prevailing Building Rent Rate”, which shall mean
the annual Rent rate then being charged by Landlord in the Building for space comparable to the Premises, as determined by Landlord, taking into consideration use, location and floor level within the Building, rental concessions then being granted
by Landlord under similar circumstances, base year and/or expense stop calculations, the date the particular rate under consideration is to become effective, and the term of the lease under consideration. However, it is specifically agreed that for
the purposes of Tenant’s renewal option only, no concession or allowance for installation of Tenant improvements or moving expenses will be included in determining the Prevailing Building Rent Rate, in as much as Tenant will already be in
possession and leasehold improvements will already have been installed in the Premises. 

  

					
			  
  

RIDER NO. 102 - PAGE 1 OF 1
		

 Rider No. 106 

SCHEDULE OF BASE RENTAL 

Base Rental shall be payable as follows: 
  

									
	 Months
	  	Cost Per
Rentable Square
Foot Per Annum	 	  	Monthly
Installment	 
	 1 through 3
	  	$	0.00	  	  	 	Rent Abated	  
	 4 through 15
	  	$	31.00	  	  	$	6,657.25	  
	 16 through 24
	  	$	31.93	  	  	$	6,856.97	  
	 25 through 37
	  	$	32.89	  	  	$	7,063.13	  
	 38 through 50
	  	$	33.87	  	  	$	7,273.58	  
	 51 through 63
	  	$	34.89	  	  	$	7,492.62	  

  

					
		 	  
  

RIDER NO. 106 - PAGE 1 OF 1

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