Document:

EXHIBIT 10.29

                 FOURTH AMENDMENT TO CONVERTIBLE LOAN AGREEMENT

      THIS FOURTH AMENDMENT TO CONVERTIBLE LOAN AGREEMENT (this "Amendment")
made as of January 26, 2001, by and among Play by Play Toys & Novelties, Inc., a
Texas corporation ("Borrower"), Renaissance Capital Group, Inc., a Texas
corporation ("Agent"), and the Lenders party to the Original Agreement defined
below ("Lenders").

                                    RECITALS

A. Borrower, Agent and Lenders entered into that certain Convertible Loan
Agreement dated as of July 3, 1997 (as amended and supplemented to the date
hereof, including pursuant to a First Amendment to Convertible Loan Agreement
dated as of October 22, 1999, the "Original Agreement"), for the purpose and
consideration therein expressed, whereby Lenders became obligated to make loans
to Borrower as therein provided.

B. Borrower, Agent and Lenders desire to amend the Original Agreement and the
Debentures to extend the existing maturity date from January 26, 2001 to
February 2, 2001.

      In consideration of the premises and the mutual covenants and agreements
contained herein and in the Original Agreement, and for other good and valuable
consideration, the receipt and sufficiency of which are hereby acknowledged, the
parties hereto do hereby agree as follows:

C. Borrower, Agent and Lenders agree that this amendment will not be valid or
binding if any funds are advanced to Warner Brothers by Borrower on or before
February 2, 2001. In the event this condition precedent is not complied with
this Fourth Amendment is void and the Borrower, Agent and Lenders will be
subject to the terms outlined in the Third Amendment to the Convertible Loan
Agreement dated January 14, 2001, wherein it provides that the Debentures shall
mature on January 26, 2001.

ARTICLE 2

                           DEFINITIONS AND REFERENCES

ARTICLE 1.1 TERMS DEFINED IN THE ORIGINAL AGREEMENT. Unless the context
otherwise requires or unless otherwise expressly defined herein, the terms
defined in the Original Agreement shall have the same meanings whenever used in
this Amendment.

ARTICLE 1.2 OTHER DEFINED TERMS. Unless the context otherwise requires, the
following terms when used in this Amendment shall have the meanings assigned to
them in this Section 1.2.

        "Amendment" means this Second Amendment to Convertible Loan Agreement.

        "Loan Agreement" means the Original Agreement as amended hereby.
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ARTICLE 2

                          AMENDMENTS TO LOAN DOCUMENTS

ARTICLE 2.1 AMENDMENT OF TERMS. The Loan Documents are hereby amended as
follows:

(a) MATURITY. Section 2.04 of the Original Agreement and Section 2 of each
Debenture are amended to provide that the Debentures shall mature on February 2,
2001.

(b) FINANCIAL COVENANTS. Section 7.01 of the Original Agreement is hereby
amended by deleting such section in its entirety.

(c) EVENTS OF DEFAULT. Section 8.01(a)(iii) of the Original Agreement is hereby
amended by adding the following to the second line following the word
"Documents,": "or in Section 9.16 of the Congress Facility,"

ARTICLE 3

                             ADDITIONAL AGREEMENTS

ARTICLE 3.1 NO WAIVER OF ANY EXISTING DEFAULTS. Borrower hereby acknowledges
that Lenders, in executing and delivering this Second Amendment to Convertible
Loan Agreement, hereby waive no Default that may be existing under the Loan
Documents as of the date of this Amendment, but instead expressly reserve any
and all of their rights, powers, and/or remedies under the Loan Documents and/or
applicable in connection with any such Existing Default.

ARTICLE 4

                        REPRESENTATIONS AND WARRANTIES

ARTICLE 4.1 REPRESENTATIONS AND WARRANTIES OF BORROWER. In order to induce each
Lender to enter into this Agreement, Borrower represents and warrants to each
Lender that:

(a) Borrower is duly authorized to execute and deliver this Amendment and is
duly authorized to perform its obligations under the Loan Documents. Borrower
has duly taken all corporate action necessary to authorize the execution and
delivery of this Amendment and to authorize the performance of the obligations
of Borrower hereunder.

(b) The execution and delivery by Borrower of this Amendment, the performance by
Borrower of its obligations hereunder and the consummation of the transactions
contemplated hereby do not and will not conflict with any provision of law,
statute, rule or regulation or of the articles of incorporation and bylaws of
Borrower, or of any material agreement, judgment, license, order or permit
applicable to or binding upon Borrower, or result in the creation of any lien,
charge or encumbrance upon any assets or properties of Borrower. Except for
those which have been obtained, no consent, approval, authorization or order of
any court or governmental authority or third party is required in connection
with the execution and delivery by Borrower of this Amendment or to consummate
the transactions contemplated hereby.

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(c) When duly executed and delivered, this Amendment will be a legal and binding
obligation of Borrower, enforceable in accordance with its terms, except as
limited by bankruptcy, insolvency or similar laws of general application
relating to the enforcement of creditors' rights and by equitable principles of
general application.

ARTICLE 4.2 REPRESENTATIONS AND WARRANTIES OF LENDERS. Each Lender hereby
represents and warrants to Borrower that it owns and holds as of the date hereof
the Debentures purchased by it under the Original Agreement, and is duly
authorized to execute and deliver this Amendment.

ARTICLE 5

                                 MISCELLANEOUS

ARTICLE 5.1 RATIFICATION OF AGREEMENTS. The Original Agreement as hereby amended
is hereby ratified and confirmed in all aspects. The Loan Documents, as they may
be amended hereby, are hereby ratified and confirmed in all respects. Any
reference to the Loan Agreement in any Loan Document shall be deemed to be a
reference to the Original Agreement as hereby amended. Any reference to the
Debentures in any Loan Document shall be deemed to be a reference to the
Debentures are hereby amended. Consistent with, but not in limitations of, the
provisions of SECTION 3.1 hereof, execution, delivery and effectiveness of this
Amendment shall not operate as a waiver of any right, power or remedy of Lenders
under the Loan Agreement, the Debentures or any other Loan Document nor
constitute a waiver of any provision of the Loan Agreement, the Debentures or
any other Loan Document.

ARTICLE 5.2 SURVIVAL OF AGREEMENTS. All representations, warranties, covenants
and agreements of Borrower herein shall survive the execution and delivery of
this Amendment and the performance hereof, and shall further survive until all
of the Obligations are paid in full. All statements and agreements contained in
any certificate or instrument delivered by Borrower hereunder or under the
Credit Agreement to any Lender shall be deemed to constitute representations and
warranties by, and/or agreements and covenants of, Borrower under this Amendment
and under the Loan Agreement.

ARTICLE 5.3 LOAN DOCUMENTS. This Amendment is a Loan Document, and all
provisions in the Loan Agreement pertaining to Loan Documents apply hereto and
thereto.

ARTICLE 5.4 GOVERNING LAW. This Amendment shall be governed by and construed in
accordance the laws of the State of Texas and any applicable laws of the United
States of America in all respects, including construction, validity and
performance.

<PAGE>
ARTICLE 5.5 COUNTERPARTIES; FAX. This Amendment may be separately executed in
counterparts and by the different parties hereto in separate counterparts, each
of which when so executed shall be deemed to constitute one and the same
Amendment. This Amendment may be validly executed by facsimile or other
electronic transmission.

      THIS AMENDMENT REPRESENTS THE FINAL AGREEMENT BETWEEN THE PARTIES AND MAY
NOT BE CONTRADICTED BY EVIDENCE OF PRIOR, CONTEMPORANEOUS, OR SUBSEQUENT ORAL
AGREEMENTS OF THE PARTIES. THERE ARE NO UNWRITTEN ORAL AGREEMENTS OF THE
PARTIES.

        [THE REMAINDER OF THIS PAGE HAS BEEN INTENTIONALLY LEFT BLANK]

<PAGE>
      IN WITNESS WHEREOF, this Amendment is executed as of the date first above
written.

                              PLAY BY PLAY TOYS & NOVELTIES, INC.

                              By: ____________________________________
                                  Name:
                                  Title:

                              RENAISSANCE US GROWTH & INCOME TRUST PLC

                              By: ____________________________________
                                  Name:
                                  Title:

                              RENAISSANCE CAPITAL GROWTH & INCOME FUND III, INC.

                              By: ____________________________________
                                  Name:
                                  Title:

                              BANC ONE CAPITAL PARTNERS II, LLC

                              By: Bank One Capital Partners Holdings, Ltd.,
                                  Manager

                              By: ____________________________________
                                  Name:
                                  Title:

                              RENAISSANCE CAPITAL GROUP, INC., as Agent

                              By: ____________________________________
                                  Name:
                                  Title:EXHIBIT 4.1

                           HEMISPHERx BIOPHARMA, INC.
                          (FORMERLY HEM RESEARCH, INC.)
                              AMENDED AND RESTATED
                             1990 STOCK OPTION PLAN

1. Administration of Plan

This plan is intended to provide for the grant of stock options to persons whose
contributions  are  important  to  the  success  of  HEM  Research,   Inc.  (the
"Company").  This Plan shall be  administered  by the Board of  Directors of the
Company.  The Board of  Directors  is  authorized  to  interpret  the Plan,  the
prescribe,  amend and rescind rules and regulations  relating to it, and to make
all other  determinations  necessary or advisable  for its  administration.  The
Board of Directors may delegate to a committee  thereof any or all of its powers
and authority with respect to the administration of the Plan, and all references
herein to the Board of Directors shall be deemed to include any such committee.

2. Shares Covered by Plan

Options  may be  granted  under the plan  while  the Plan is in  effect  for the
purchase of not more than  460,798(1)  shares of the Common Stock,  $.001(1) par
value ("Common Stock"),  of the Company.  Shares covered by unexercised  options
that are no longer exercisable for any reason shall continue to be available for
issuance under options granted  hereunder for purposes of applying for foregoing
limitation.  Shares  delivered on exercise of options may be made available from
authorized and unissued stock or from stock held in the Treasury of the Company.

3. Eligibility

The Board of  Directors  may grant stock  options  under the Plan to  employees,
directors  and  officers of the Company and to  consultants,  advisors and other
persons  whose  contributions  are  important  to the  success  of the  Company,
provided that bonafide services shall be rendered by such consultants other than
in  connection  with the  offer  and  sale of  securities  in a  capital-raising
transaction.

4. Grant of Options

The  recipients of options  granted  under the Plan,  the number of shares to be
covered by each option, and the exercise price,  vesting terms, if any, duration
and  other  terms of each  option  (not  inconsistent  with the  Plan)  shall be
determined by the Board of Directors.

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5. Option Agreements

Each person to whom an option is granted  shall  enter into a written  agreement
with the Company setting forth the terms and conditions of the option granted to
him.

6. Duration of Options

No option  granted under the Plan shall be  exercisable  more than ten years and
one month from the date as of which the option agreement is executed.

7. Rights of a Stockholder

An optionee  shall have no rights as a  stockholder  with  respect to any shares
covered by his  options  until he shall have become the holder of record of such
shares, and no adjustment shall be made, except adjustments  pursuant to section
8 hereof, for dividends (ordinary or extraordinary  whether in cash,  securities
or other  property) or  distributions  or other rights in respect of such shares
for which the record date is prior to the date on which he shall have become the
holder of record thereof.

8. Effect of Change in Stock Subject to the Plan

If there is any change in the shares of Common Stock of the Company  through the
declaration of stock  dividends or through  recapitalization  resulting in stock
split-ups or  combinations  or exchanges of shares or  otherwise,  the number of
shares available for option, the exercise price of outstanding  options, and the
number of shares  subject to any option shall be  appropriately  adjusted by the
Board of Directors, and in their discretion,  in such cases, fractional parts of
shares may be disregarded.

9. Amendment and Discontinuance

The Board of  Directors  may from time to time alter or suspend  and at any time
discontinue the Plan.  However, no action of the Board of Directors may alter or
impair an optionee's  rights under any  outstanding  option  previously  granted
under the Plan without the consent of the holder of the option.

10. Termination Date

The Plan shall remain in effect until terminated by the Board of Directors.

Date: October 23, 1989

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Note (1): Plan amended to reflect  stock splits since 1990  consisting of a 10:1
Reverse Stock Split  effected in 1992, a 2.17015:1  Reverse Stock Split effected
on May 9, 1994 and a 2:1 Forward Stock Split on November 30, 1994. Also reflects
a change in par value to $.001 per share effective June 29, 1994.

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