Document:

EX-10.7

 Exhibit 10.7 
 AMENDMENT NO. 1 TO 
 SHAREHOLDERS AGREEMENT 

AMENDMENT NO. 1 TO SHAREHOLDERS AGREEMENT, dated as of [            ], 2013,
by and among Quintiles Transnational Holdings Inc., a North Carolina corporation (the “Company”), and certain of the Company’s shareholders identified below (the “Amendment”). Capitalized terms used herein but
not defined shall have the meaning ascribed to such terms in the Shareholders Agreement (as defined below). Except as provided herein, all other terms, conditions and provisions of the Shareholders Agreement shall remain in full force and effect.

 RECITALS 
 WHEREAS, in connection with a statutory share exchange between Quintiles Transnational Corp., a North Carolina corporation (“QTRN”), and the Company on December 14, 2009, the Company
assumed the rights and obligations of QTRN as set forth in that certain Shareholders Agreement, dated as of January 22, 2008, by and among QTRN and the Shareholders named therein (as supplemented by the Supplement to Shareholders Agreement,
dated August 9, 2012, by and among the Company and certain of the Company’s shareholders identified therein, the “Shareholders Agreement”); 
 WHEREAS, Section 5.2 of the Shareholders Agreement provides that the Shareholders Agreement may be amended by a written instrument signed by the Company, the Bain Shareholders, the Temasek
Shareholders, the TPG Shareholders, the DG Shareholders and the 3i Shareholders, subject to certain exceptions described therein; 
 WHEREAS, in accordance with Section 5.5 of the Shareholders Agreement, for action to be taken by any of the Shareholder groups described above, the holders of more than 50% of the Common Stock of the
Company then held by that group must vote in favor of the action; 
 WHEREAS, the parties to this Amendment desire to amend the
Shareholders Agreement in connection with a proposed initial public offering of the Company; and 
 WHEREAS, contemporaneously
with and in consideration of the execution of this Amendment, (i) the Company is adopting the Second Amended and Restated Certificate of Incorporation, (ii) the Company and certain shareholders identified therein are entering into the
Second Amended and Restated Registration Rights Agreement, and (iii) QTRN is entering into Amendment No. 1 to the Management Agreement, dated January 22, 2008, by and among QTRN, Bain Capital Partners, LLC, GF Management Company, LLC,
TPG Capital, L.P., Cassia Fund Management Pte Ltd., 3i Corporation and Aisling Capital, LLC. 
 AGREEMENT 

NOW, THEREFORE, in consideration of the foregoing and the mutual covenants and agreements contained herein, and intending to be legally
bound hereby, the Company and the Shareholders named above hereby agree as follows: 

 1. The definition of “NovaQuestTM Investments” in Section 1.1 of the
Shareholders Agreement is hereby deleted. 
 2. The definition of a “Qualifying Offering” in Section 1.1 of the
Shareholders Agreement is hereby amended by adding the following language at the end of the definition: 

“; provided, however, that the consummation of the offering of the shares registered on the Company’s Form S-1
Registration Statement, File No. 333-186708, shall be deemed to be a Qualifying Offering.” 
 3. Section 3.1(a)
is hereby amended by (i) deleting the sentence “Additionally, the 3i Shareholders shall have the right to appoint one (1) observer to the Board (the ‘3i Observer’)” in its entirety and (ii) deleting the
sentence “Additionally, the 3i Observer initially shall be Denis Ribon” in its entirety. 
 4. A new
Section 3.1(c) of the Shareholders Agreement shall be inserted as follows: 
 “(c) Compensation.
Following a Qualified Offering, no director shall be eligible to receive compensation from the Company for serving as a director unless such director has been affirmatively determined by the Board to be an “independent director” under
applicable law and in accordance with the rules and regulations of the Commission and the NYSE (or any other applicable SRO) (an “Independent Director”).” 

5. A new Section 3.1(d) of the Shareholders Agreement shall be inserted as follows: 

“(d) Nomination. With respect to any Nominee that is designated by a Shareholder Group pursuant to such
Shareholder Group’s right to designate such Nominee, the Company shall use its reasonable best efforts to cause the Board and Governance, Quality and Nominating Committee to, if applicable (i) include such Nominee in the slate of nominees
recommended by the Board for the applicable class of directors for election by the shareholders of the Company or (ii) appoint such Nominee to fill a vacancy on the Board created by the departure of a Nominee designated by such Shareholder
Group. The Company agrees to include such Nominee in the applicable proxy statement for such shareholder meeting.” 
 6.
Section 3.4(a) of the Shareholders Agreement shall be amended and replaced as follows: 
 “(a)
Committees. The Board shall designate an Audit Committee, a Compensation and Talent Development Committee, and a Governance, Quality and Nominating Committee. Notwithstanding anything contained herein to the contrary, the Board may act to
change the title and function of the committees of the Board, provided that at all times the Company shall maintain any committee of the Board that is required under applicable law and pursuant to applicable rules and regulations of the Commission
and the NYSE (or any other applicable SRO). Except as provided below, the composition of all committees of the Board shall be as determined by the Board, provided, that the Bain Shareholders as a group, the DG Shareholders as a group, the TPG
Shareholders as a group and the 3i Shareholders as a group shall each have the right to designate at least one director to serve on each current and any future committee of the Board, other than the Audit Committee, which shall be comprised
initially of the Disinterested Nominees; provided, however, a Nominee of the DG Shareholders, the Bain Shareholders, the TPG Shareholders or the 3i Shareholders may serve on a committee only to the extent such Nominee is permitted to serve on such
committee under applicable law and pursuant to applicable rules and regulations of the Commission and the NYSE (or other applicable SRO).” 

  
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 7. Section 3.4(c) of the Shareholders Agreement shall be amended and replaced as
follows: 
 “(c) Certain Transactions and Investment Decisions. Notwithstanding anything to the
contrary herein, after the Effective Date (i) any asset divestiture by the Company or Subsidiary of the Company in excess of $10 million shall require the affirmative vote of a majority of the Board and (ii) any transactions (other than
the Recapitalization Transaction) entered into between the Company or any of its Subsidiaries, on the one hand, and any Shareholder or Affiliate or Associate of any Shareholder, on the other hand (an “Affiliate Transaction”), shall
require the affirmative vote of a majority of the Board with the Nominee(s) of the interested Shareholder abstaining from such vote. Each Shareholder shall promptly inform the Company and such Shareholder’s Nominees, if any, of any proposed
Affiliate Transaction with an Affiliate or Associate of such Shareholder; provided, however, that in the event that a Shareholder is not aware, and, in the ordinary course of its business could not reasonably be expected to be aware, that a proposed
transaction is an Affiliate Transaction with an Affiliate or Associate of such Shareholder, such Affiliate Transaction shall not be deemed to violate clause (ii) of the immediately preceding sentence.” 

8. Section 3.5 of the Shareholders Agreement is hereby amended by deleting the proviso at the end thereof and replacing it with the
following: 
 “With respect to clauses (A), (B) and (C) of this Section 3.5, such five and
ten percent threshold, as the case may be, shall be calculated using the basic weighted average number of shares of the Company’s Common Stock outstanding for the most recent fiscal period disclosed in the Company’s filings with the
Commission; provided, that any of the following shall be excluded from such calculation: (i) shares of Common Stock issued by the Company in connection with an acquisition by the Company approved by the Board and (ii) shares of
Common Stock issued by the Company (other than the Qualifying Offering and any shares of Common Stock issued in connection with a registration relating to the sale of securities to participants in a Company employee stock option, stock purchase or
similar employee benefit plan registered on Form S-8). Once any Shareholder Group no longer has the right to designate a Nominee as described earlier in this paragraph, such Shareholder Group shall (i) promptly notify the Company in writing of
such fact and (ii) if requested in writing by a majority of the Independent Directors of the Company, cause a director designated as a Nominee of such Shareholder Group to tender his or her resignation from the Board, which shall be effective
immediately prior to the next annual meeting of shareholders of the Company (regardless of whether the term of the director so resigning would otherwise expire at that meeting) or at any earlier date, in the discretion of the director. In
considering whether to request such a resignation, the Independent Directors of the Company shall comply with the procedures set forth in a Policy for Independent Director Consideration of Board Resignations, which shall have been approved by the
Board.” 

  
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 9. A new Section 3.10 of the Shareholders Agreement shall be inserted as follows:

 “3.10. Procedures Regarding Certain Corporate Opportunities. 

(a) In the event that a director of the Company who was designated as a Nominee to the Board by an Exempted Person’s
applicable Shareholder Group has actual knowledge that an investment has been made after the date hereof in a Competitor by a late stage private equity fund managed by an Exempted Person, such Exempted Person shall notify the Company thereof as
promptly as practicable after the making of such investment and cooperate reasonably with the Company at its request to create appropriate protective procedures with respect to the flow of information; provided that the foregoing shall not be
required if prohibited by law, regulation, contractual obligation or otherwise. This provision is in addition to any other duties the designated Nominee may have at law as a result of the investment, after giving effect to any provisions in the
Company’s Articles of Incorporation relating to corporate opportunities. Solely for purposes of this Section 3.10 (i) “Competitor” means any pharmaceutical services organization that provides either clinical research
or contract sales services to customers in the pharmaceutical, biotechnology or medical device industries; provided, that a fully integrated pharmaceutical, biotechnology or medical device company that may occasionally provide these types of
services to third parties, but that does not derive significant revenues from such services, shall not be deemed a “Competitor” pursuant to this Section 3.10 and (ii) “Exempted Person” shall have the meaning
ascribed to such term in the Company’s Articles of Incorporation. 
 (b) Notwithstanding any provisions in
the Company’s Articles of Incorporation relating to corporate opportunities, prior to any investment in any of Pharmaceutical Product Development, Inc., Covance, Inc., PAREXEL International Corporation, inVentiv Health, Inc., ICON plc, PRA
International, Inc., PDI, Inc., Publicis Touchpoint Solutions, Inc., United Drug plc, or any of their successors or controlled affiliates, by a late stage private equity fund managed by an Exempted Person, such Exempted Person shall give written
notice of such proposed investment to the Board and shall not consummate such investment unless it is approved by a disinterested majority of the Board in its discretion (which approval shall be deemed to have been given if the Board does not notify
such Exempted Person otherwise within 21 days of the notice of the proposed investment having been received). A violation of this Section 3.10(b) shall not be subject to any limitations on liability contained in any provisions related to
corporate opportunities in the Company’s Articles of Incorporation. For the avoidance of doubt, the restrictions contained in this Section 3.10(b) shall not apply to any hedge fund, venture fund, debt fund or other non late stage private
equity fund managed by an Exempted Person.” 
 10. Section 4.3 of the Shareholders Agreement is hereby amended by
deleting the reference to “Section 4.1 of the Registration Rights Agreement” contained therein and replacing it with a reference to “Section 5.1 of the Registration Rights Agreement.” 

11. The first sentence of Section 5.4(a) of the Shareholders Agreement is hereby amended by inserting the following at the end of
the second proviso thereof: 
 “, provided, further, that with respect to each of the Temasek
Shareholders, the Institutional Shareholders, the Management Shareholders, and Cynthia M. Roberts, this Agreement shall automatically terminate (including, for the avoidance of doubt, any and all provisions related to the Temasek Nominee)
immediately prior to the effective date of the Company’s Form S-1 Registration Statement, File No. 333-186708, and, for the avoidance of doubt, such termination with respect to such Shareholders shall not be subject to the provisions of
subsection (b) below.” 

  
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 12. The last sentence of Section 5.4(a) of the Shareholders Agreement is hereby deleted
and replaced with the following: 
 “Upon termination of this Agreement, Article I (including, for the avoidance of doubt,
any terms not defined therein but referenced in Section 1.1(c)) and Article V (except for the second sentence of Section 5.2) shall survive termination.” 
 13. Section 5.4(b)(ii) of the Shareholders Agreement is hereby deleted and replaced in its entirety with “(ii) [Reserved], and.” 

14. Section 5.4(b)(iii) of the Shareholders Agreement is hereby amended by deleting “, Temasek Shareholders” contained
therein. 
 15. Section 5.4(c) of the Shareholders Agreement is hereby amended by deleting the proviso at the end thereof.

 This Amendment may be executed in any number of counterparts, each of which will be deemed an original, but all of which
together will constitute one and the same instrument.
 [Signature Pages Follow] 

  
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 [Signature Page to Amendment to Shareholders Agreement] 

IN WITNESS WHEREOF, the Company and the Shareholders listed below have executed and delivered this Amendment No. 1 to the
Shareholders Agreement as of the date first above written. 
  

			
	Company:
	
	 QUINTILES TRANSNATIONAL

HOLDINGS INC.

		
	By:	 	 
		 	Name:
		 	 Title:

 [Signature Page to Amendment to Shareholders Agreement] 

 

					
	 DG Shareholders:
  

 

	Dennis B. Gillings, CBE
	
	
	 Cynthia M. Roberts

	
	Bain Shareholders:
	
	 BAIN CAPITAL INTEGRAL INVESTORS 2008, L.P.

	
	 By: Bain Capital Investors, LLC, its general partner

			
		 	By:	 	 
		 	 Name:

		 	 Title:
	 	Managing Director
	
	Temasek Shareholders:
	
	 TEMASEK LIFE SCIENCES PRIVATE LIMITED

		
	By:	 	 
		 	 Name:

		 	 Title:

		
	TPG Shareholders:	 	
	
	 TPG QUINTILES HOLDCO II LLC

		
	By:	 	 
		
		 	 Name:

		 	 Title:

 [Signature Page to Amendment to Shareholders Agreement] 

 

					
	 3i Shareholders:

	
	 3i US GROWTH HEALTHCARE FUND 2008 L.P.

		
	 By:
	 	3i U.S. GROWTH CORPORATION
	 Its:
	 	General Partner
			
		 	By:	 	  

		 	Name:	 	
		 	Title:	 	
	
	 Institutional Shareholders:

	
	 AISLING CAPITAL II, L.P.

		
	By:	 	  

	Name:	 		 	
	Title:	 		 	
	
	 PERSEUS-SOROS BIOPHARMACEUTICAL
 FUND, L.P.

		
	By:	 	  

	Name:	 		 	
	Title:	 		 	
	
	 Management Shareholders:

	
	  
 Thomas H.
PikeEX-10.13

 Exhibit 10.13 
 INDEMNIFICATION AGREEMENT 
 This Indemnification Agreement, dated as of
            ,          (this “Agreement”), is made by and between Quintiles Transnational Holdings Inc., a North Carolina
corporation (the “Company”), Quintiles Transnational Corp., a North Carolina corporation and wholly owned subsidiary of the Company (“Quintiles Transnational,” together with the Company the “Quintiles
Companies” and each a “Quintiles Company”), and                  (“Indemnitee”). 

RECITALS 

WHEREAS, the Company and Indemnitee are each aware of the exposure to litigation of members of the Board of Directors of the Company (the
“Board”) when exercising their duties to the Company; 
 WHEREAS, the Company desires to benefit from the
services of highly qualified, experienced and otherwise competent persons such as Indemnitee; 
 WHEREAS, Article IV of the
Company’s Amended and Restated Bylaws (the “Bylaws”) provides for indemnification of directors and permits the Company to enter into an agreement with any of its directors providing for indemnification against liability and
advancement of expenses; 
 WHEREAS, Indemnitee is a director of the Company and, at the Company’s request, Quintiles
Transnational, and his or her willingness to serve in such capacities is predicated, in substantial part, upon the Quintiles Companies’ willingness to enter into this Agreement; and 

WHEREAS, in recognition of the need to provide Indemnitee with substantial protection against personal liability, in order to procure
Indemnitee’s service or continued service as a director of each Quintiles Company and to enhance Indemnitee’s ability to serve the Quintiles Companies in an effective manner, and in order to provide such protection pursuant to express
contract rights (intended to be enforceable irrespective of, among other things, any amendment to the Company’s Amended and Restated Articles of Incorporation (the “Articles”) or Bylaws or the Amended and Restated Articles of
Incorporation or Amended and Restated Bylaws of Quintiles Transnational, any change in the composition of the Board or any change-in-control or business combination transaction relating to the Company), the Quintiles Companies wish to provide in
this Agreement for indemnification against Indemnifiable Losses and the advancement of Expenses (each as defined below) to Indemnitee as set forth in this Agreement and for the continued coverage of Indemnitee under D&O Insurance (as defined
below) maintained by the Company and/or Quintiles Transnational. 

 AGREEMENT 
 Now, therefore, in consideration of the foregoing premises and the mutual covenants contained herein, the receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows:

 1. Certain Definitions. In addition to terms defined elsewhere herein, the following terms have the following meanings when used in
this Agreement with initial capital letters: 
 (a) “Change in Control”: 

(i) Prior to the Trigger Date, a “Change in Control” shall be deemed to have occurred in either of the following
circumstances occurring after the date hereof: 
 (A) a Sale of the Company; or 

(B) a majority of the directors are not Incumbent Directors. 
 (ii) beginning on the Trigger Date, a “Change in Control” shall be deemed to have occurred in any of the following circumstances: 

(A) any Person is or becomes the Beneficial Owner of securities of the Company representing 20% or more of the Voting Stock without the
prior approval of at least a majority of the Incumbent Directors; provided that a “Change in Control” will not be deemed to have occurred if (1) a Person acquires Beneficial Ownership of 20% or more of the Voting Stock as a
result of a reduction in the number of shares of the Company’s Voting Stock or (2) a Shareholder Group that was the Beneficial Owner of securities of the Company representing 20% or more of the Voting Stock on the Trigger Date continues to
be the Beneficial Owner of securities of the Company representing 20% or more of the Voting Stock, in each case, unless and until such Person or Shareholder Group thereafter becomes the Beneficial Owner of any additional shares of Voting Stock
representing 1% or more of the then-outstanding Voting Stock, other than in an acquisition directly from the Company that is approved by a majority of the Incumbent Directors or other than as a result of a stock dividend, stock split or similar
transaction effected by the Company in which all holders of Voting Stock are treated equally; 
 (B) a sale of the Company
(whether by merger, consolidation, recapitalization, reorganization, sale of securities, sale of assets or otherwise) is consummated, unless immediately following such transaction (1) more than 50% of the members of the governing body of the
surviving entity were Incumbent Directors at the time of execution of 

  
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the initial agreement providing for such transaction, (2) no Person (other than a Shareholder Group that was the Beneficial Owner of securities of the Company representing 20% or more of the
Voting Stock immediately prior to such sale) is the Beneficial Owner of 20% or more of the then-outstanding Voting Stock, and (3) more than 50% of the then-outstanding Voting Stock is Beneficially Owned by all or substantially all of the
individuals and entities who were the Beneficial Owners of the Voting Stock immediately prior to such transaction in substantially the same proportions as their ownership immediately prior to such transaction; 

(C) the shareholders of the Company approve a plan of complete liquidation or dissolution of the Company or an agreement for the sale or
disposition by the Company (in one transaction or a series of related transactions) of all or substantially all of the Company’s assets; or 
 (D) a majority of the directors are not Incumbent Directors. 
 (b)
“Beneficially Own,” “Beneficial Owner” and “Beneficial Ownership” mean having, or a Person who has, direct or indirect ownership within the meaning of Rule 13d-3 promulgated under the Exchange Act.

 (c) “Claim” means, except as stated below, any threatened, pending or completed action, demand, suit or
proceeding, whether civil, criminal, administrative, arbitrative, investigative or other and whether formal or informal, including but not limited to any investigation, inquiry, hearing or alternative dispute resolution process. 

(d) “D&O Insurance” means an insurance policy or policies providing directors’ and officers’ liability
insurance, whether on a primary or excess basis; provided, however, that “D&O Insurance” does not include any insurance policy providing insurance coverage to any Sponsor Shareholder. 

(e) “Exchange Act” means the Securities Exchange Act of 1934, as amended. 

(f) “Expenses” means, to the extent actually and reasonably incurred by or on behalf of Indemnitee, attorneys’ and
experts’ fees and expenses and all other costs and expenses in connection with investigating, defending, being a witness in or otherwise participating in (including on appeal), or preparing to investigate, defend, be a witness in or otherwise
participate in (including on appeal), any Indemnifiable Claim or Standard of Conduct Determination (as defined in Section 5(b)). 
 (g) “Incumbent Directors” means the individuals who, as of the date hereof, are directors of the Company and any individual becoming a director subsequent to the date hereof whose
election, nomination for election by the Company’s shareholders or appointment was approved by the then Incumbent Directors in accordance with the 

  
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Bylaws or who was elected or appointed to the Board in accordance with Article III of the Shareholders Agreement; provided, that an individual shall not be an Incumbent Director if such
individual’s election or appointment to the Board occurs as a result of an actual or threatened election contest (as described in Rule 14a-12(c) of the Exchange Act) with respect to the election or removal of Directors or other actual or
threatened solicitation of proxies or consents by or on behalf of a Person other than the Board. 
 (h) “Indemnifiable
Claim” means any Claim in which Indemnitee is or is threatened to be involved as a party, witness or otherwise by reason of the fact that he or she is or was a director of the applicable Quintiles Company, or is or was serving at the
request of such Quintiles Company as a director, officer, partner, member, trustee, employee or agent of another foreign or domestic corporation, partnership, limited liability company, joint venture, trust, employee benefit plan or other
enterprise, or as a trustee or administrator under any employee benefit plan of such Quintiles Company or any wholly owned subsidiary thereof, or by reason of any action alleged to have been taken or omitted in such capacity, including a Claim to
enforce any provision of this Agreement. 
 (i) “Indemnifiable Losses” means any and all Losses relating to,
arising out of or resulting from any Indemnifiable Claim. 
 (j) “Independent Counsel” means a law firm, or a
member of a law firm, that is experienced in matters of corporation law and neither presently is, nor in the past five years has been, retained to represent: (i) a Quintiles Company or any subsidiary thereof or Indemnitee in any matter material
to either such party, or (ii) any other named (or as to a threatened matter, reasonably likely to be named) party to the Indemnifiable Claim giving rise to a claim for indemnification hereunder. Notwithstanding the foregoing, the term
“Independent Counsel” shall not include any person who, under the applicable standards of professional conduct then prevailing, would have a conflict of interest in representing any of the Company, Quintiles Transnational or Indemnitee in
an action to determine Indemnitee’s rights under this Agreement. 
 (k) “Losses” means, to the extent
actually and reasonably incurred by or on behalf of Indemnitee and except as provided below, any and all Expenses, damages, losses, liabilities, fines, penalties, judgments and amounts paid in settlement. 

(l) “Person” means any person (within the meaning of Section 13(d)(3) or 14(d)(2) of the Exchange Act), other than
the Quintiles Companies or any employee benefit plan sponsored by a Quintiles Company. 
 (m) “Sale of the
Company” shall have the meaning set forth in the Shareholders Agreement. 
 (n) “Shareholder” and
“Shareholder Group” shall have the meaning set forth in the Shareholders Agreement. 

  
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 (o) “Shareholders Agreement” means the Shareholders Agreement dated
January 22, 2008, by and among the Company (as assignee of Quintiles Transnational) and the shareholders named therein, as such agreement may be amended, modified, supplemented, restated or replaced. 

(p) “Sponsor Shareholder” means any current or former Shareholder, any Affiliate (as defined in the Shareholders
Agreement) of such Shareholder (other than the Quintiles Companies and their subsidiaries), and/or any other investment entity or related management company that is advised by the same investment adviser as any of the foregoing entities or by an
Affiliate (as defined in the Shareholders Agreement) of such investment adviser. 
 (q) “Trigger Date” shall
have the meaning set forth in the Articles. 
 (r) “Voting Stock” means securities of the Company entitled to
vote generally in the election of directors (or similar governing bodies). 
 2. Indemnification Obligation. Subject to
Section 5, the applicable Quintiles Company shall indemnify Indemnitee against all Indemnifiable Losses to the fullest extent permitted or required by the laws of the State of North Carolina as in effect from time to time.
Notwithstanding the foregoing, no indemnification, reimbursement or payment shall be required of the applicable Quintiles Company hereunder: 
 (a) with respect to any Claim or any part thereof arising out of acts or omissions for which applicable law prohibits indemnification; 

(b) with respect to any Claim or part thereof or Losses where a determination has been made pursuant to Section 5(b) that the
Indemnitee’s activities in question were at the time taken known or believed by him or her to be clearly in conflict with the best interests of the applicable Quintiles Company or Indemnitee otherwise failed to satisfy the applicable standard
of conduct for indemnification under North Carolina law; 
 (c) with respect to any Claim or part thereof or Losses arising under
Section 16(b) of the Exchange Act, or similar provisions of federal, state or local statutory or common law, pursuant to which Indemnitee shall be obligated to pay any penalty, fine, settlement or judgment; provided, however, that the Company
shall, in accordance with Section 3, advance Expenses in connection with Indemnitee’s defense of any such Claim, which advances shall be repaid to the Company unless it is ultimately determined that Indemnitee is entitled to
indemnification; 
 (d) with respect to any Claim initiated by Indemnitee without the prior written consent or authorization of
the Board of Directors of the applicable Quintiles Company, provided that this exclusion shall not apply with respect to any Claim brought by Indemnitee to enforce any provision of this Agreement, whether by claim, cross claim, or counterclaim in a
legal proceeding, arbitration or otherwise; or 
 (e) for which payment has actually been received by or on behalf of Indemnitee
under any applicable D&O Insurance. 

  
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 3. Advancement of Expenses. Prior to the final disposition of any Indemnifiable Claim and without
regard to Indemnitee’s ultimate entitlement to indemnification under the other provisions of this Agreement and without regard to whether a Standard of Conduct Determination (as hereinafter defined) has been made as to such Indemnifiable Claim
or part thereof, the Company or Quintiles Transnational, as applicable, will advance to or reimburse Indemnitee for any and all Expenses relating to, arising out of or resulting from such Indemnifiable Claim paid or incurred by Indemnitee;
provided, that the Quintiles Companies shall have no obligation to advance Expenses incurred by Indemnitee with respect to any Claim initiated by Indemnitee (other than a Claim brought by Indemnitee to enforce any provision of this
Agreement); and provided further, that Indemnitee shall execute and deliver to the applicable Quintiles Company an unsecured undertaking by or on behalf of Indemnitee to repay any amounts paid, advanced or reimbursed by the applicable
Quintiles Company hereunder unless it shall ultimately be determined that Indemnitee is entitled to indemnification. Indemnitee shall promptly repay, without interest, any amounts actually advanced to Indemnitee that, at the final disposition of the
Indemnifiable Claim to which the advance related, were in excess of amounts paid or payable by Indemnitee in respect of Expenses relating to, arising out of or resulting from such Indemnifiable Claim. The Company or Quintiles Transnational, as
applicable, shall advance, pay or reimburse Expenses pursuant to this Section 3 within thirty (30) calendar days of its receipt of a written request from Indemnitee accompanied by reasonable documentation evidencing the amount or
nature of the Expenses, subject to such Quintiles Company’s prior receipt of a written request pursuant to Section 4 and the undertaking referenced in this Section 3. 

4. Procedure for Indemnification. To obtain indemnification or advancement of expenses under this Agreement, Indemnitee shall submit to the
applicable Quintiles Company a written request therefor, including a brief description (based upon information then available to Indemnitee) of such Indemnifiable Claim or Indemnifiable Loss. 
 5. Determination That Indemnification Is Proper. 
 (a) To the extent that
Indemnitee has been wholly successful, on the merits or otherwise, in the defense of any Indemnifiable Claim, Indemnitee shall be indemnified against all Indemnifiable Losses relating to, arising out of or resulting from such Indemnifiable Claim in
accordance with Section 2 and no Standard of Conduct Determination (as defined in Section 5(b)) shall be required. 
 (b) To the extent that the provisions of Section 5(a) are inapplicable to an Indemnifiable Claim or part thereof that shall have been finally disposed of, or if any Indemnifiable Claim is
concluded without a final adjudication on the issue of liability, the applicable Quintiles Company shall, subject to the provisions of Sections 2(a)–2(e), 

  
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nevertheless indemnify Indemnitee for Indemnifiable Losses unless a determination is made that indemnification of Indemnitee is not proper in the circumstances because his or her actions in
question were, at the time taken, known or believed by him or her to be clearly in conflict with the best interests of the applicable Quintiles Company or otherwise failed to satisfy the applicable standard of conduct for indemnification under North
Carolina law (a determination of whether or not such actions were so known or believed or otherwise failed to satisfy the foregoing standard shall be a “Standard of Conduct Determination”). The knowledge and/or actions, or failure
to act, of any other director, officer, partner, member, trustee, employee or agent of a Quintiles Company or any entity or other enterprise of which Indemnitee, at the request of either Quintiles Company, is or was serving or agreed to serve as a
director officer, partner, member, trustee, employee or agent shall not be imputed to the Indemnitee for purposes of determining his or her right to indemnification under this Agreement. Any such Standard of Conduct Determination shall be made in
accordance with this paragraph. If a Change in Control shall not have occurred, or if a Change in Control shall have occurred but Indemnitee shall have requested that the Standard of Conduct Determination be made pursuant to this sentence, the
Standard of Conduct Determination shall be made either (i) by the Board of Directors of the applicable Quintiles Company by majority vote of a quorum consisting of directors not at the time parties to the Indemnifiable Claim; (ii) if a
quorum cannot be obtained under subdivision (i), by a majority vote of a committee designated by the Board of Directors of the applicable Quintiles Company (in which designation directors who are parties may participate), consisting solely of two or
more directors not at the time parties to the Indemnifiable Claim; or (iii) by Independent Counsel selected by the Board of Directors of the applicable Quintiles Company or its committee in the manner prescribed by subdivision (i) or (ii),
or if a quorum cannot be obtained under subdivision (i) or a committee cannot be designated under subdivision (ii), by a majority vote of the full Board of Directors (in which selection directors who are parties may participate). If a Change in
Control shall have occurred and Indemnitee shall not have requested that the Standard of Conduct Determination be made pursuant to the prior sentence, the Standard of Conduct Determination shall be made by Independent Counsel selected by Indemnitee.
Any Standard of Conduct Determination made by Independent Counsel shall be delivered in a written opinion addressed to the applicable Board of Directors, a copy of which shall be provided to Indemnitee. 

(c) The applicable Quintiles Company shall use its reasonable best efforts to cause any Standard of Conduct Determination required under
Section 5(b) to be made as promptly as practicable. If (i) the person or persons empowered or selected under this Section 5 to make the Standard of Conduct Determination shall not have made a determination within sixty
(60) days after the later of (A) receipt by the applicable Quintiles Company of written notice from Indemnitee advising the applicable Quintiles Company of the final disposition or other conclusion without final adjudication on the issue
of liability of the applicable Indemnifiable Claim and (B) the selection of an Independent Counsel, if such determination is to be made by Independent Counsel, that is permitted under the provisions of Section 5(d) to make such
determination and (ii) Indemnitee shall have fulfilled his or her obligations set forth in Section 5(e), then Indemnitee shall be deemed to have satisfied the applicable standard of conduct;

  
 7 

 
provided, that such sixty-day period may be extended for a reasonable time, not to exceed an additional thirty (30) days, if the person or persons making such determination in good
faith require such additional time to obtain or evaluate documentation or other information relating thereto. 
 (d) If a
Standard of Conduct Determination is to be made by Independent Counsel pursuant to Section 5(b), the party who selected such Independent Counsel shall give notice to the other party advising such party of the identity of the Independent Counsel
selected. In either case, the Quintiles Companies or the Indemnitee, as applicable, may, within five business days after receiving written notice of selection from the other, deliver to the other a written objection to such selection; provided,
however, that such objection may be asserted only on the ground that the Independent Counsel so selected does not satisfy the criteria set forth in the definition of “Independent Counsel” in Section 1, and the objection shall set
forth with particularity the factual basis of such assertion. Absent a proper and timely objection, the person or firm so selected shall act as Independent Counsel. If such written objection is timely made and substantiated, (i) the Independent
Counsel so selected may not serve as Independent Counsel unless and until such objection is withdrawn or a court has determined that such objection is without merit and (ii) the non-objecting party may, at its option, select an alternative
Independent Counsel and give written notice to the other party advising such party of the selection, in which case the provisions of the two immediately preceding sentences and clause (i) of this sentence shall apply to such subsequent
selection and notice. If applicable, the provisions of clause (ii) of the immediately preceding sentence shall apply to successive alternative selections. If no Independent Counsel shall have been selected within 30 days after the party who
makes the selection sends the initial notice of selection, the party who did not make the selection may petition the courts of the State of North Carolina for resolution of any objection which shall have been made by such party to the other
party’s selection and/or for the appointment as Independent Counsel of a person or firm selected by the Court or by such other person as the Court shall designate. In all events, the Quintiles Companies shall pay all of the reasonable fees and
expenses of the Independent Counsel incurred in connection with making a Standard of Conduct Determination pursuant to this Agreement. 
 (e) Indemnitee shall cooperate with the person or persons making a Standard of Conduct Determination pursuant to Section 5(b), including providing to such person or persons, upon reasonable advance
request, any documentation or information which is not privileged or otherwise protected from disclosure and which is reasonably available to Indemnitee and which the person or persons making such determination reasonably request. Provided that the
person or persons making such Standard of Conduct Determination determine that Indemnitee is entitled to indemnification hereunder, the applicable Quintiles Company shall further indemnify Indemnitee against any and all Expenses actually and
reasonably incurred by Indemnitee in so cooperating with the person or persons making such Standard of Conduct Determination. 

(f) The Quintiles Companies and Indemnitee acknowledge that, in certain instances, applicable law or public policy may prohibit, or
otherwise limit, the Quintiles Companies’ obligation to indemnify their directors under this Agreement or otherwise. 
 (g)
In the event that (i) a determination is made pursuant to Section 5(b) that Indemnitee is not entitled to indemnification under this Agreement, (ii) advancement of Expenses is not timely made pursuant to Section 3,
(iii) payment of indemnification is not made pursuant to Section 5(a) within thirty (30) days after receipt by the applicable Quintiles Company of a written request therefor, or (iv) payment of indemnification pursuant to
Section 5(b) is not made within thirty (30) days after a Standard of Conduct Determination in which there is not a determination that indemnification is not proper under the circumstances, the Indemnitee shall be entitled to seek a
judicial determination as to his or her entitlement to such indemnification or advancement of Expenses. 

  
 8 

 6. Contribution. To the fullest extent permissible under applicable law, if the indemnification
provided for in this Agreement is unavailable to Indemnitee for any reason whatsoever, the applicable Quintiles Company, in lieu of indemnifying Indemnitee, shall contribute the amount of Indemnifiable Losses incurred by Indemnitee or on his or her
behalf, in such proportion as is deemed fair and reasonable in light of all the circumstances of the Indemnifiable Claim, in order to reflect (a) the relative benefits received by such Quintiles Company and Indemnitee as a result of the
event(s) and/or transaction(s) giving rise to such Indemnifiable Claim; and/or (b) the relative fault of such Quintiles Company (and its directors, officers, employees and agents) and Indemnitee in connection with such event(s) and/or
transaction(s). The determination of the proportion to be contributed by the applicable Quintiles Company to Indemnitee shall be made in the same manner as a Standard of Conduct Determination pursuant to Section 5 hereof. 

7. Non-Exclusivity. The rights of the Indemnitee hereunder shall be in addition to any other rights the Indemnitee may have under the laws of the
State of North Carolina, the Quintiles Companies’ organizational documents, any other agreement, a vote of shareholders or a resolution of the applicable Board of Directors or otherwise. 
 8. Successful Defense. To the extent that Indemnitee has been successful on the merits or otherwise in defense of an Indemnifiable Claim or in defense of any claim, issue or matter therein, he or
she shall be indemnified against any and all Expenses in connection therewith. For purposes of this Section and without limitation, the termination of any claim, issue or matter in such a Claim by dismissal, with or without prejudice, shall be
deemed to be a successful result as to such claim, issue or matter. 
 9. Presumptions and Burdens of Proof. Indemnitee shall be
entitled, in any Standard of Conduct Determination or judicial proceeding, to a presumption that he or she is entitled to indemnification, advancement of Expenses or both under this Agreement if he or she has provided a written request for
indemnification pursuant to Section 4. The applicable Quintiles Company shall bear the burden of proving, by a preponderance of the evidence, that Indemnitee is not entitled to indemnification or advancement. For purposes of this
Agreement, the termination of any Indemnifiable Claim by judgment, order, settlement, conviction or upon a plea of no contest or its equivalent, is not, of itself, determinative that Indemnitee did not
(a)

  
 9 

 
conduct himself or herself in good faith, (b) reasonably believe (i) in the case of conduct in his or her official capacity with the applicable Quintiles Company, that his or her
conduct was in the applicable Quintiles Company’s best interests and (ii) in all other cases, that his or her conduct was at least not opposed to its best interests, and (c) in the case of any Indemnifiable Claim that is a criminal
Claim, had no reasonable cause to believe that his or her conduct was unlawful. 
 10. Insurance. 

(a) The Quintiles Companies shall obtain and maintain D&O Insurance with reputable insurance companies on terms with respect to
coverage and amount (including with respect to the payment of Expenses) no less favorable than those of the D&O Insurance for the directors of the applicable Quintiles Company in effect on the date hereof, except for any changes approved by the
Board of Directors of the applicable Quintiles Company prior to a Change in Control, provided that such coverage is available on commercially reasonable terms. Indemnitee shall be covered by such D&O Insurance, in accordance with its terms, to
the maximum extent of the coverage available for any director of the applicable Quintiles Company. 
 (b) Subject to the
limitations set forth in Section 12(a) and except as provided in any D&O Insurance maintained by the applicable Quintiles Company, the obligation of a Quintiles Company to indemnify Indemnitee under this Agreement shall be secondary
to any applicable D&O Insurance, and all such D&O Insurance shall be primary to such Quintiles Company’s obligations hereunder, subject to any applicable deductible. Except as provided in any D&O Insurance maintained by the
applicable Quintiles Company, in no event shall this Agreement provide (by operation or law or otherwise) any insurance company any right to subrogation to Indemnitee’s rights hereunder. Except as provided in any D&O Insurance maintained by
the applicable Quintiles Company, in no event shall any insurance company acquire (by subrogation, assignment or otherwise) any right to pursue Indemnitee’s rights hereunder. 

(c) Upon request by Indemnitee, the applicable Quintiles Company shall provide Indemnitee copies of any applicable D&O Insurance
maintained by such Quintiles Company. The Quintiles Companies shall promptly notify Indemnitee of any material change in such D&O Insurance coverage. 
 11. Additional Capacities. To the extent that Indemnitee, at the request of either Quintiles Company, is or was serving or has agreed to serve as a director, officer, partner, member, trustee,
employee or agent of another foreign or domestic corporation, partnership, limited liability company, joint venture, trust, employee benefit plan or other enterprise, or as a trustee or administrator under any employee benefit plan of either
Quintiles Company or any wholly owned subsidiary thereof, the indemnification provided hereunder will be secondary to any liability insurance and/or indemnification obligations provided by such other entity, and those obligations will be primary to
the Quintiles Companies’ obligations hereunder; provided, however, that so long as Indemnitee has taken reasonable steps to exercise his or her rights and remedies against such entity prior to seeking indemnification or advance
hereunder, Indemnitee will not be required to exhaust all rights and remedies against such entity prior to enforcing any provision of this Agreement. 

  
 10 

 12. Duplication of Payments; Subrogation. 

(a) A Quintiles Company shall not be liable under this Agreement to make any payment in connection with any Indemnifiable Claim to the
extent that Indemnitee has otherwise received payment of the amounts otherwise payable as indemnity hereunder (including, without limitation, pursuant to any D&O Insurance maintained by a Quintiles Company); provided, however,
that, as between a Quintiles Company, on the one hand, and any Sponsor Shareholder with whom Indemnitee is or was affiliated and any insurer providing insurance coverage to such Sponsor Shareholder, on the other hand, the applicable Quintiles
Company (i) is the indemnitor of first resort (i.e., its obligations to Indemnitee are primary and any indemnification or advancement obligations of any Sponsor Shareholder with whom Indemnitee is affiliated and the obligations of any insurer
of such Sponsor Shareholder to provide insurance coverage with respect to the same Losses and Expenses are secondary), (ii) shall be required to advance the full amount of Expenses incurred by Indemnitee and shall be liable for the full amount
of Expenses and other Losses to the extent legally permitted and as required by the terms of this Agreement, its governing documents and any other agreements it may have with Indemnitee, without regard to any rights Indemnitee may have against such
Sponsor Shareholder, and (iii) unconditionally and irrevocably waives, relinquishes, releases such Sponsor Shareholder from and agrees not to exercise any rights that it may have with respect to any and all claims for contribution, subrogation
or any other recovery of any kind in respect thereof. 
 (b) Subject to the limitations set forth in Section 12(a),
in the event of payment under this Agreement, the Quintiles Companies shall be subrogated to the extent of such payment to all of the related rights of recovery of Indemnitee against any other persons or entities. Indemnitee, as a condition of
receiving indemnification from the Quintiles Companies, shall execute all documents and do all things that the Quintiles Companies may deem necessary or desirable to perfect such right of recovery, including the execution of such documents necessary
to enable the Quintiles Companies effectively to enforce any such recovery. 
 13. Cooperation in Defense and Settlement. Indemnitee
shall not make any admission or effect any settlement with respect to any Indemnifiable Claim without the applicable Quintiles Company’s written consent unless Indemnitee shall have determined to undertake his or her own defense in such matter
and has waived any rights to indemnification by or advancement from such Quintiles Company (arising under this Agreement or otherwise, except to the extent that indemnification may be required by law). The applicable Quintiles Company shall have the
authority to settle any Indemnifiable Claim to which Indemnitee is a party so long as it either (i) obtains Indemnitee’s written consent to such settlement or (ii) such settlement solely involves the payment of money, would not impose
(directly or indirectly) any Expense on Indemnitee and includes a complete and unconditional release of Indemnitee from all liability on any claims that are the subject matter of such Indemnifiable Claim. Neither Indemnitee nor such Quintiles

  
 11 

 
Company will unreasonably withhold consent to the proposed settlement. Indemnitee acknowledges and agrees that if it is ultimately determined that Indemnitee unreasonably withheld consent, his or
her unreasonable failure to so consent shall constitute a waiver of all of his or her rights to indemnification and advancement hereunder. Indemnitee and the applicable Quintiles Company shall cooperate to the extent reasonably possible with each
other and with the applicable Quintiles Company’s insurers in attempts to defend and/or settle such proceeding. 
 14. Assumption of
Defense. 
 (a) Except as otherwise provided in Section 14(b) below, the applicable Quintiles Company, jointly
with any other indemnifying party similarly notified, may assume Indemnitee’s defense in any Indemnifiable Claim, with counsel reasonably satisfactory to Indemnitee and the applicable Quintiles Company. After notice from the applicable
Quintiles Company to Indemnitee of such Quintiles Company’s election to assume such defense, the Quintiles Companies will not be liable to Indemnitee under this Agreement or otherwise for Expenses subsequently incurred by Indemnitee in
connection with the defense thereof, other than reasonable costs of investigation or as otherwise provided below. Indemnitee shall have the right to employ counsel in such Indemnifiable Claim, but the fees and expenses of such counsel incurred after
notice from the applicable Quintiles Company of its assumption of the defense thereof shall be at Indemnitee’s own expense unless: 
 (i) The employment of counsel by Indemnitee has been authorized by a Quintiles Company; or 
 (ii) Indemnitee shall have reasonably concluded that (A) counsel employed by a Quintiles Company initially is unacceptable or later becomes unacceptable to Indemnitee and such Quintiles Company has
failed to employ reasonably acceptable counsel in a reasonably timely manner; (B) there may be a conflict of interest between Indemnitee and a Quintiles Company (or another party being represented jointly with a Quintiles Company) in the
conduct of the defense of such Indemnifiable Claim; or (C) the applicable Quintiles Company shall not have employed counsel to assume the defense of such Indemnifiable Claim within a reasonable time following receipt of a written request.

 (b) A Quintiles Company shall not be entitled to assume the defense of Indemnitee with respect to any Indemnifiable Claim as
to which Indemnitee shall have made either of the conclusions provided for in Section 14(a)(ii)(A) or Section 14(a)(ii)(B). 
 (c) In the event that Indemnitee notifies a Quintiles Company that he or she has made any of the conclusions set forth in Section 14(a)(ii), the applicable Quintiles Company shall be required
to indemnify Indemnitee against and advance or reimburse to Indemnitee all Expenses incurred (whether incurred by Indemnitee before or after the delivery of such notice) with respect to such Indemnifiable Claim while any of the conditions set forth
in Section 14(a)(ii) are present to the fullest extent provided hereunder (including Expenses incurred by Indemnitee with respect to the preparation and delivery of such notice). 

  
 12 

 (d) If the Quintiles Company disagrees with Indemnitee’s conclusion under
Section 14(a)(ii), such Quintiles Company shall, within 30 days after the receipt of notice from Indemnitee, appoint Independent Counsel consistent with the procedures specified in Section 5(b) to resolve the dispute.
Provided that Independent Counsel determines that Indemnitee’s conclusion under Section 14(a)(ii) was reasonable, the applicable Quintiles Company shall further indemnify Indemnitee against any and all Expenses actually and
reasonably incurred by Indemnitee in so cooperating with such Independent Counsel. 
 (e) For the avoidance of doubt, regardless
of whether a Quintiles Company has assumed or is entitled to assume Indemnitee’s defense, the Quintiles Companies shall be entitled to participate in any Indemnifiable Claim at their own expense. 

15. Successors and Binding Agreement: 
 (a) The Quintiles Companies shall require any successor (whether direct or indirect, by purchase, merger, consolidation, reorganization or otherwise) to all or substantially all of the business or assets
of the Quintiles Companies, by agreement in form and substance reasonably satisfactory to Indemnitee, expressly to assume and agree to perform this Agreement in the same manner and to the same extent the Quintiles Companies would be required to
perform if no such succession had taken place. This Agreement shall be binding upon and inure to the benefit of the Quintiles Companies and any successor to the Quintiles Companies, including without limitation any person acquiring directly or
indirectly all or substantially all of the business or assets of the Quintiles Companies, whether by purchase, merger, consolidation, reorganization or otherwise (and such successor will thereafter be deemed the “Company” or
“Quintiles Transnational,” as applicable, for purposes of this Agreement). 
 (b) The indemnification and advancement
of Expenses provided by this Agreement shall continue as to a person who has ceased to be a director or officer or who is deceased and shall inure to the benefit of and be enforceable by the personal or legal representatives, executors,
administrators, heirs, distributees, legatees and other successors of such person. 
 (c) This Agreement is personal in nature
and neither of the parties hereto may, without the written consent of the other, assign or delegate this Agreement or any rights or obligations hereunder except as expressly provided in Sections 15(a) and 15(b). Without limiting the
generality or effect of the foregoing, Indemnitee’s right to receive payments hereunder shall not be assignable, whether by pledge, creation of a security interest or otherwise, other than by a transfer by Indemnitee’s will or by the laws
of descent and distribution, and, in the event of any attempted assignment or transfer contrary to this Section 15(c), the Quintiles Companies shall have no liability to pay any amount so attempted to be assigned or transferred.

  
 13 

 16. Miscellaneous: 
 (a) Notice of Claim; Notices. Indemnitee agrees promptly to notify the applicable Quintiles Company in writing upon being served with any summons, citation, subpoena, complaint, indictment,
information or other document relating to any Claim or matter which may be subject to indemnification or advancement hereunder. Any failure to so notify the applicable Quintiles Company shall not relieve such Quintiles Company of any obligation
which it may have to Indemnitee under this Agreement or otherwise unless and only to the extent that such failure or delay materially prejudices such Quintiles Company. All notices, requests and other communications hereunder must be in writing and
will be deemed to have been duly given only if delivered personally against written receipt or by facsimile transmission or mailed by prepaid first class mail, return receipt requested, or sent by overnight courier prepaid to the parties at the
following addresses or facsimile numbers: 
 If to the Company and/or Quintiles Transnational, to: 

Quintiles Transnational Holdings Inc./Quintiles Transnational Corp. 

4820 Emperor Blvd. 
 Durham, North Carolina 27703 
 Facsimile: (919) 941-7345 

Attention: General Counsel 
 with a copy to: 
 Smith, Anderson, Blount, Dorsett, Mitchell & Jernigan,
L.L.P. 
 2300 Wells Fargo Capitol Center 
 Post Office Box 2611 
 Raleigh, North Carolina 27602-2611 

Facsimile: (919) 821-6800 
 Attention: Gerald F. Roach, Esq. 
 If to the Indemnitee, to: 

Indemnitee 

[Address] 

with a copy to: 

[Counsel name and address] 

  
 14 

 (b) Governing Law. The validity, interpretation, construction and performance of this
Agreement shall be governed by, and construed and enforced in accordance with, the substantive laws of the State of North Carolina, without giving effect to its principles of conflict of laws. The Quintiles Companies and Indemnitee each hereby
irrevocably consent that both parties are subject to the jurisdiction of the state courts of the State of North Carolina for all purposes in connection with any action or proceeding that arises out of or relates to this Agreement, and further agree
that the sole and exclusive venue for any such dispute shall be the General Court of Justice, Superior Court Division, in Durham County, North Carolina. The parties stipulate and agree that any such dispute shall be designated by agreement of the
parties as a “mandatory complex business case” pursuant to N.C.G.S. § 7A-45.4 (as such statute may be amended from time to time) or, in the alternative, as a discretionary “complex business” case under Rule 2.1 of the North
Carolina General Rules of Practice for the Superior and District Courts (as such rule may be amended from time to time), and both parties hereby irrevocably waive any objection to such dispute being so designated. In the event the parties are unable
to secure designation of the dispute as a complex business case, or if such designation is revoked at any time, the parties agree that they shall request that the dispute be designated as an “exceptional” case pursuant to Rule 2.1 of the
North Carolina General Rules of Practice for the Superior and District Courts (as such rule may be amended from time to time) and agree to cooperate in good faith to secure such designation. 

(c) Validity. If any provision of this Agreement or the application of any provision hereof to any person or circumstance is held
invalid, unenforceable or otherwise illegal, the remainder of this Agreement and the application of such provision to any other person or circumstance shall not be affected, and the provision so held to be invalid, unenforceable or otherwise illegal
shall be reformed to the extent, and only to the extent, necessary to make it enforceable, valid or legal. In the event that any court or other adjudicative body shall decline to reform any provision of this Agreement held to be invalid,
unenforceable or otherwise illegal as contemplated by the immediately preceding sentence, the parties hereto shall take all such action as may be necessary or appropriate to replace the provision so held to be invalid, unenforceable or otherwise
illegal with one or more alternative provisions that effectuate the purpose and intent of the original provisions of this Agreement as fully as possible without being invalid, unenforceable or otherwise illegal. 

(d) Amendment. This Agreement may not be modified or amended except by a written instrument executed by or on behalf of each of
Indemnitee and each Quintiles Company. 
 (e) Waiver. The observance of any term of this Agreement may be waived (either
generally or in a particular instance and either retroactively or prospectively) only by a writing signed by the party against which such waiver is to be asserted, and no waiver of any of the provisions of this Agreement shall be deemed or shall
constitute a waiver of any other provisions hereof (whether or not similar) nor shall such waiver constitute a continuing waiver. 

  
 15 

 (f) Entire Agreement. No agreements or representations, oral or otherwise, expressed
or implied, with respect to the subject matter hereof have been made by either party that are not set forth expressly in this Agreement. 
 (g) Headings. The headings used in this Agreement have been inserted for convenience of reference only and do not define or limit the provisions hereof. 

(h) Certain Interpretive Matters. Unless the context of this Agreement otherwise requires, (i) “it” or
“its” or words of any gender include each other gender; (ii) words using the singular or plural number also include the plural or singular number, respectively; (iii) the terms “hereof,” “herein,”
“hereby” and derivative or similar words refer to this entire Agreement; (iv) the term “Section” refers to the specified Section of this Agreement; (v) the terms “include,” “includes” and
“including” shall be deemed to be followed by the words “without limitation” (whether or not so expressed); and (vi) the word “or” is disjunctive but not exclusive. No provision of this Agreement will be
interpreted in favor of, or against, either of the parties hereto by reason of the extent to which any such party or its counsel participated in the drafting thereof or by reason of the extent to which any such provision is inconsistent with any
prior draft hereof or thereof. 
 (i) Counterparts. This Agreement may be executed in one or more counterparts, and
delivered by facsimile or other means of electronic transmission, each of which shall be deemed to be an original but all of which together shall constitute one and the same agreement. 
 17. Prospective Effect. Notwithstanding anything to the contrary contained anywhere in this Agreement, in no event will this Agreement be deemed to apply to any Claim existing against Indemnitee
prior to the date of this Agreement, any Losses incurred by Indemnitee prior to the date of this Agreement or any Losses relating to any Claim existing against Indemnitee prior to the date of this Agreement. 

[Signature Page to Follow] 

  
 16 

 IN WITNESS WHEREOF, Indemnitee has executed and each Quintiles Company has caused its duly
authorized representative to execute this Agreement effective as of the date first above written. 
  

			
	QUINTILES TRANSNATIONAL HOLDINGS INC.
		
	By:	 	  

		
		 	Name:
		
		 	Title:
	
	QUINTILES TRANSNATIONAL CORP.
		
	By:	 	  

		
		 	Name:
		
		 	Title:
	
	[INDEMNITEE]
		
	By:	 	  

		
		 	Name:

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