Document:

Master Security Agreement

 Exhibit 10.28 
 MASTER SECURITY AGREEMENT 
 NO. 5051091 
 Dated as of May 31, 2005 (“AGREEMENT”) 
 THIS AGREEMENT is between
OXFORD FINANCE CORPORATION (together with its successors and assigns, if any, “SECURED PARTY”) and Alsius Corporation (“DEBTOR”). Secured Party has an office at 133 N. Fairfax Street, Alexandria, VA 22314. Debtor is a corporation
organized and existing under the laws of the state of California. Debtor’s mailing address and chief place of business is 15770 Laguna Canyon Road, Suite 150, Irvine, California 92618. 
  

	1.	CREATION OF SECURITY INTEREST. 

 Debtor grants to Secured
Party, its successors and assigns, a security interest in and against the Collateral (as that term is defined herein). This security interest is given to secure the payment and performance of all debts, obligations and liabilities of any kind
whatsoever of Debtor to Secured Party under this Agreement and the Debt Documents, now existing or arising in the future, including but not limited to the payment and performance of certain Promissory Notes from time to time executed by Debtor
(collectively “NOTES” and each a “NOTE”), and any renewals, extensions and modifications of such debts, obligations and liabilities (such Notes, debts, obligations and liabilities are called the “INDEBTEDNESS”).

 If Debtor shall at any time acquire a commercial tort claim, as defined in the Code, Debtor shall immediately notify Secured Party in
writing signed by Debtor of the brief details thereof and grant to Secured Party in such writing a security interest therein and in the proceeds thereof, all upon the terms of this Agreement, with such writing to be in form and substance
satisfactory to Secured Party. 
 Unless otherwise provided by applicable law, notwithstanding anything to the contrary contained in this
Agreement, to the extent that Secured Party asserts a purchase money security interest in any items of Collateral (the “PMSI COLLATERAL”): (i) the PMSI Collateral shall secure only that portion of the Indebtedness which has been
advanced by Secured Party to enable Debtor to purchase, or acquire rights in or the use of such PMSI Collateral (the “PMSI INDEBTEDNESS”), and (ii) no other Collateral shall secure the PMSI Indebtedness. 
 If Debtor at any time achieves Seven Million Dollars ($7,000,000) in revenues during a continuous 12-month period, then Debtor may, at its option, incur
Additional Indebtedness as set forth in clause (v) of the definition of Permitted Indebtedness (the “A/R FACILITY”). Secured Party agrees that the Liens granted to it hereunder in Account Collateral shall be subordinate to the Liens
of the future lender providing the A/R Facility. Notwithstanding the foregoing, the Indebtedness hereunder shall not be subordinate in right of payment to any obligations to other lender and Secured Party’s rights and remedies hereunder shall
not in any way be subordinate to the rights and remedies of any such lender. So long as no default has occurred, Secured Party agrees to execute and deliver such agreements and documents as may be reasonably requested by Debtor or other lenders from
time to time which set forth the lien subordination described in this paragraph and are reasonably acceptable to Secured Party. Secured Party shall have no obligation to execute any agreement or document which would impose obligations, restrictions
or lien priority on Secured Party which are less favorable to Secured Party than those described in this paragraph. “ACCOUNT COLLATERAL” means Debtor’s accounts receivable due or to become due to Debtor under all purchase orders and
contracts for the sale of products or the performance of services or both by Debtor (and related general intangibles in the nature of rights to payment) and the proceeds thereof). 
  

	2.	REPRESENTATIONS, WARRANTIES AND COVENANTS OF DEBTOR. 

 Debtor represents, warrants and covenants as of the date of this Agreement and as of the date of each Note (as appropriate) that: 
  

	 	(a)	Due Organization. Debtor’s exact legal name is as set forth in the preamble of this Agreement and Debtor is, duly organized, existing and in good standing under the laws of the
State set forth in the preamble of this Agreement, has its chief executive offices at the location specified in the preamble, and is, and will remain duly qualified and licensed in every jurisdiction wherever necessary to carry on its business and
operations; 

  

	 	(b)	Power and Capacity to Enter Into and Perform Obligations. Debtor has adequate power and capacity to enter into, and to perform its obligations under this Agreement, each Note and
any other documents evidencing, or given in connection with, any of the Indebtedness (all of the foregoing are called the “DEBT DOCUMENTS”); 

  

	 	(c)	Due Authorization. This Agreement and the other Debt Documents have been duly authorized, executed and delivered by Debtor and constitute legal, valid and binding agreements
enforceable in accordance with their terms, except to the extent that the enforcement of remedies may be limited under applicable bankruptcy and insolvency laws; 

  

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	 	(d)	Approvals and Consents. No approval, consent or withholding of objections is required from any governmental authority or instrumentality with respect to the entry into, or
performance by Debtor of any of the Debt Documents, except any already obtained; 

  

	 	(e)	No Violations or Defaults. The entry into, and performance by, Debtor of the Debt Documents will not (i) violate any of the organizational documents of Debtor or any judgment,
order, law or regulation applicable to Debtor, or (ii) result in any breach of or constitute a default under any contract to which Debtor is a party, or result in the creation of any lien, claim or encumbrance on any of Debtor’s property
(except for liens in favor of Secured Party) pursuant to any indenture, mortgage, deed of trust, bank loan, credit agreement, or other agreement or instrument to which Debtor is a party; 

  

	 	(f)	Litigation. There are no suits or proceedings pending in court or before any commission, board or other administrative agency against or affecting Debtor which could, in the
aggregate, have a material adverse effect on Debtor, its business or operations, or its ability to perform its obligations under the Debt Documents, nor does Debtor have reason to believe that any such suits or proceedings are threatened;

  

	 	(g)	Solvency. The fair salable value of Debtor’s assets (including goodwill minus disposition costs) exceeds the fair value of its liabilities; the Debtor is not left with
unreasonably small capital after the transactions in this Agreement or any Notes and Debtor is able to pay its debts (including trade debts) as they mature. 

  

	 	(h)	Financial Statements Prepared In Accordance with GAAP. All financial statements delivered to Secured Party in connection with the Indebtedness have been prepared in accordance with
generally accepted accounting principles, and since the date of the most recent financial statement, there has been no material adverse change in Debtor’s financial condition; 

  

	 	(i)	Use of Collateral. The Collateral is not, and will not be, used by Debtor for personal, family or household purposes; 

  

	 	(j)	Collateral in Good Condition and Repair. The Collateral is, and will remain, in good condition and repair and Debtor will not be negligent in its care and use;

  

	 	(k)	Ownership of Collateral. Debtor is, and will remain, the sole and lawful owner, and in possession of, the Collateral, and has the sole right and lawful authority to grant the
security interest described in this Agreement; 

  

	 	(l)	Encumbrances. The Collateral is, and will remain, free and clear of all liens, claims and encumbrances of any kind whatsoever, except for Permitted Liens; 

 

	 	(m)	Intellectual Property. Debtor will take all reasonable steps to (i) protect, defend and maintain the validity and enforceability of the Intellectual Property and promptly
advise Secured Party in writing of material infringements and (ii) not allow any Intellectual Property material to Debtor’s business to be abandoned, forfeited or dedicated to the public without Secured Party’s written consent;

  

	 	(n)	Taxes. All federal, state and local tax returns required to be filed by Debtor have been filed with the appropriate governmental agencies and all taxes due and payable by Debtor
have been timely paid. Debtor will pay when due all taxes, assessments and other liabilities except as contested in good faith and by appropriate proceedings and for which adequate reserves have been established; 

  

	 	(o)	No Defaults. No event or condition exists under any material agreement, instrument or document to which Debtor is a party or may be subject, or by which Debtor or any of its
properties are bound, which constitutes a default or an event of default thereunder, or will, with the giving of notice, passage of time, or both, would constitute a default or event of default thereunder; 

  

	 	(p)	Certification of Financial Information. All reports, certificates, schedules, notices and financial information submitted by Debtor to the Secured Party pursuant to this Agreement
shall be certified as true and correct by the president or chief financial officer of Debtor; and 

  

	 	(q)	Notice of Material Adverse Change. Debtor shall give the Secured Party prompt written notice of any event, occurrence or other matter which (a) has resulted or is likely to
result in a material adverse change in its financial condition, business operations, prospects, product development, technology, or business or contractual relations with third parties of Debtor, or (b) which would impair the ability of Debtor
to perform its obligations hereunder or under any of the other financing agreements to which it is a party, or (c) which would impair the ability of Secured Party to enforce the Indebtedness or realize upon the Collateral.

  

	 	(r)	.[intentionally omitted] 

  

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	 	(s)	Transactions with Affiliates. Debtor shall not, without the prior written consent of Secured Party, directly or indirectly enter into or permit to exist any material transaction
with any Affiliate of Debtor except for equity financings and transactions that are in the ordinary course of Debtor’s business, upon fair and reasonable terms that are no less favorable to Debtor than would be obtained in an arm’s length
transaction with a nonaffiliated Person. 

  

	 	(t)	Audits. Debtor shall allow Secured Party to audit Debtor’s Collateral at Debtor’s expense, which amount shall not exceed $2,500. Such audits will be conducted no more
often than annually unless a default has occurred and is continuing. 

  

	 	(u)	Primary Account and Wire Transfer Instructions. Debtor maintains its Primary Account (the “PRIMARY OPERATING ACCOUNT”) and the Wire Transfer Instructions for the Primary
Operating Account are as follows: 

 Silicon Valley Bank 
 3003 Tasman Drive 
 Santa Clara, CA 95054

 ABA No.: 121140399 
 Account
No.: 3300392162 (Checking Account) 
 Account Name: Alsius Corporation 
 Debtor hereby agrees that Loans will be advanced to the account specified above and regularly scheduled payments will be automatically debited from the
same account. In addition to the Primary Operating Account identified hereinabove, Debtor maintains the following other deposit and investment accounts: 
 Silicon Valley Bank 
 3003 Tasman Drive 
 Santa Clara, CA 95054 
 ABA No.: 121140399

 Account No.: 0600309575 (Money Market Account 
                         #886-00101-1-8ZGQ—Investment Securities) 
 Account Name: Alsius Corporation 
  

	 	(v)	Right to Invest. Debtor hereby grants to Secured Party a right (but not an obligation) to invest in each Subsequent Financing of Debtor, up to (A) $750,000 if the Subsequent
Financing is $4,000,000 or more of gross cash proceeds to Debtor, or (B) $375,000 if the Subsequent Financing is less than $4,000,000 gross cash proceeds to Debtor, all on the same terms, conditions and pricing offered to the lead investor of
such financing. Debtor shall give Secured Party at least twenty (20) days prior written notice of each Subsequent Financing containing the terms, conditions and pricing of each Subsequent Financing. As used herein, “SUBSEQUENT
FINANCING” shall mean the next and any future round of private equity financing in which the Debtor receives, in the aggregate, at least $2,000,000 of gross cash proceeds (excluding any bridge debt financing except to the extent actually
converted to equity in the Debtor). The rights granted to Secured Party under this Section 2(v) shall terminate upon Debtor’s merger with or consolidation into any other entity or a sale of all or substantially all of Debtor’s assets

  

	 	(w)	Notice of Investor Abandonment. Debtor shall give the Secured Party prompt written notice Secured Party if (a) it is the clear intention of Debtor’s investors to not
continue to fund the Debtor in the amounts and timeframe necessary to enable Debtor to satisfy the Indebtedness as it becomes due and payable or (b) there is a material impairment in the perfection or priority of the Secured Party’s
security interest in the Collateral. 

  

	3.	COLLATERAL. 

 The Debtor, covenants and agrees that, so
long as any of the Debt Documents shall remain in effect, or unless the Secured Party shall otherwise consent in writing: 
  

	 	(a)	Possession of Collateral; Inspection of Collateral. Until the declaration of any default, Debtor shall remain in possession of the Collateral; except that Secured Party shall have
the right to possess (i) any chattel paper or instrument that constitutes a part of the Collateral, and (ii) any other Collateral in which Secured Party’s security interest may be perfected only by possession. Secured Party may
inspect any of the Collateral during normal business hours after giving Debtor reasonable prior notice. 

  

	 	(b)	Maintenance of Collateral. Debtor shall (i) use the Collateral only in its trade or business, (ii) maintain all of the Collateral in good operating order and repair,
normal wear and tear excepted, (iii) use and maintain the Collateral only in compliance with manufacturers recommendations and all applicable laws, and (iv) keep all of the Collateral free and clear of all liens, claims and encumbrances
(except for Permitted Liens). 

  

	 	(c)	Disposition of Collateral. Secured Party does not authorize and Debtor agrees it shall not (i) part with possession of any of the Collateral (except to Secured Party, for
maintenance and repair or in the sale of goods in the ordinary course of business), (ii) remove any of the Collateral from the continental United States (other than the following Collateral: (aa) approximately 40 Cool Guard Systems located at
customer sites in Europe, and 

  

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	 	(bb)	office furniture, laptop computers, 2 vehicles, leasehold improvements, inventory necessary for maintenance and repair of customer systems and other miscellaneous equipment
necessary for Debtor’s service center in the Netherlands in an aggregate value not exceeding $400,000.00] or (iii) sell, rent, lease, mortgage, license, grant a security interest in or otherwise transfer or encumber (except for Permitted
Liens or the sale of goods in the ordinary course of business) any of the Collateral. Once goods are sold in the ordinary course of business, Secured Party shall have no further security interest in such goods, and such goods shall be released from
any liens by Secured Party; provided that Secured Party keeps a security interest in all proceeds of such sold goods. . 

  

	 	(d)	Taxes. Debtor shall pay promptly when due all taxes, license fees, assessments and public and private charges levied or assessed on any of the Collateral, on its use, or on this
Agreement or any of the other Debt Documents. At its option, if Debtor has failed to do so, Secured Party may discharge taxes, liens, security interests or other encumbrances at any time levied or placed on the Collateral and may pay for the
maintenance, insurance and preservation of the Collateral and effect compliance with the terms of this Agreement or any of the other Debt Documents. Debtor agrees to reimburse Secured Party, on demand, all reasonable costs and expenses incurred by
Secured Party in connection with such payment or performance and agrees that such reimbursement obligation shall constitute Indebtedness. 

  

	 	(e)	Books and Records. Debtor shall, at all times, keep accurate and complete records of the Collateral, and Secured Party shall have the right to inspect and make copies of all of
Debtor’s books and records relating to the Collateral during normal business hours, after giving Debtor reasonable prior notice. 

  

	 	(f)	Third Party Possession of Collateral. Debtor agrees and acknowledges that any third person who may at any time possess all or any portion of the Collateral shall be deemed to hold,
and shall hold, the Collateral as the agent of, and as pledge holder for, Secured Party. Secured Party may at any time give notice to any third person described in the preceding sentence that such third person is holding the Collateral as the agent
of, and as pledge holder for, the Secured Party. 

  

	 	(g)	Receivables. As to each and every Receivable (a) it is a bona fide existing obligation, valid and enforceable against the Account Debtor for a sum certain for sales of goods
shipped or delivered, or goods leased, or services rendered in the ordinary course of business; (b) all supporting documents, instruments, chattel paper and other evidence of indebtedness, if any, delivered to the Secured Party are complete and
correct and valid and enforceable in accordance with their terms, and all signatures and endorsements that appear thereon are genuine, and all signatories and endorsers, to Debtor’s knowledge, have full capacity to contract; (c) to the
best of the Debtor’s knowledge, the Account Debtor is liable for and will make payment of the amount expressed in such Receivable according to its terms; (d) except in the ordinary course of business, it will be subject to no discount,
deduction, setoff, counterclaim, return, allowance or special terms of payment without the prior approval of the Secured Party; (e) it is subject to no dispute, defense or offset, real or claimed; (f) it is not subject to any prohibition
or limitation upon assignment; (g) it has not been redated or reissued in satisfaction of prior Receivables; (h) the Debtor has full right and power to grant the Secured Party a security interest therein and the security interest granted
in such Receivable to the Secured Party in this Agreement, when perfected, will be a valid first security interest which will inure to the benefit of the Secured Party without further action. The warranties set out herein shall be deemed to have
been made with respect to each and every Receivable now owned or hereafter acquired by the Debtor. 

  

	 	(h)	Bailees. The Inventory is not now and shall not at any time hereafter be stored with a bailee, warehouseman, or similar party without the Secured Party’s prior written consent.
If any Inventory is so stored, the Debtor will, concurrent with storing such Inventory, cause any such bailee, warehouseman, or similar party to issue and deliver to the Secured Party, in a form acceptable to the Secured Party, warehouse receipts in
the Secured Party’s name evidencing the storage of the Inventory. All such warehouse receipts do and will evidence ownership of the Inventory stored by the issuers thereof, and the holder thereof is and will continue to be the owner of good and
marketable title of same, free and clear of any Liens or encumbrances. All such warehouse receipts are and will be genuine, valid and enforceable by the holder thereof in accordance with their terms and all statements thereon are and will be true
and accurate in all respects. 

  

	 	(i)	Change of Address. All of the Collateral is located in and will in the future be in the possession of the Debtor at its address stated above or at such other addresses as may be set
forth on the attached Schedule A. The Debtor has not at any time within the past four (4) months either (a) maintained Inventory or Equipment or (b) maintained its chief executive office or its records with respect to the Receivables
at any other location and shall not do so hereafter except with the prior written consent of the Secured Party. The Secured Party shall be entitled to rely upon the foregoing unless it receives 14 days’ advance written notice of a change in the
address of the Debtor’s executive offices or location of the Collateral. 

  

	 	(j)	 Schedules of Receivables. Upon the written request of Secured Party, deliver to the Secured Party schedules of all outstanding Receivables. Such schedules shall be
in form satisfactory to the Secured Party and shall show the age of such Receivables in intervals of not more than thirty (30) days, and contain such other information and be accompanied by such supporting documents as the Secured Party may
from time to time prescribe. The Debtor shall also deliver to the Secured Party copies of the Debtor’s invoices, sales journals, evidences of shipment or delivery and such other schedules and information as the Secured Party may reasonably
request. The items to be provided under this Section are to be prepared and 

  

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delivered to the Secured Party from time to time solely for its convenience in maintaining records of the Collateral and the Debtor’s failure to give
any of such items to the Secured Party shall not affect, terminate, modify or otherwise limit the Secured Party’s security interest granted herein. 

  

	 	(k)	Consignment. If at any time any of the Inventory is placed by the Debtor on consignment, other than goods placed with dealers, with any person or entity (“CONSIGNEE”), the
Debtor shall, prior to the delivery of such consigned Inventory: 

  

	 	a.	Provide the Secured Party with all consignment agreements and other instruments and documentation to be used in connection with such consignment, all of which agreements,
instruments, and documentation shall be acceptable in form and substance to the Secured Party; 

  

	 	b.	Prepare and file appropriate financing statements with respect to any consigned Inventory showing the Consignee as debtor, the Debtor as secured party, and the Secured Party as
assignee of the Debtor; 

  

	 	c.	Prepare and file appropriate financing statements with respect to any consigned Inventory showing the Debtor as debtor, and the Secured Party as secured party;

  

	 	d.	After all financing statements referred to in the previous two subsections have been filed, conduct a search of all filings made against the Consignee in all jurisdictions in which
the Inventory to be consigned is to be located while on consignment, and deliver to the Secured Party copies of the results of all such searches; and 

  

	 	e.	Notify, in writing, all creditors of the Consignee that are or may be holders of security interests in the Inventory to be consigned, that the Debtor expects to deliver certain
Inventory to the Consignee, all of which Inventory shall be described in such notice by item or type. 

  

	 	(l)	Fixtures. Not permit any item of the Equipment to become a fixture to real estate or an accession to other property without the prior written consent of the Secured Party, and the
Equipment is now and shall at all times remain personal property except with the Secured Party’s prior written consent. If any of the Collateral is or will be attached to real estate in such a manner as to become a fixture under applicable
state law and if such real estate is encumbered, the Debtor will obtain from the holder of each Lien or encumbrance a written consent and subordination to the security interest hereby granted, or a written disclaimer of any interest in the
Collateral, in a form acceptable to the Secured Party. 

  

	 	(m)	Chattel Paper. Promptly, upon request by the Secured Party, deliver, assign, and endorse to the Secured Party all chattel paper and all other documents held by the Debtor in
connection therewith. 

  

	 	(n)	Copies of Government Contracts. Make available to the Secured Party, at the request of the Secured Party, a copy of each Government Contract in which the Secured Party has a
security interest and a copy of each amendment thereto or modification thereof which changes the price of such contract or the amount funded to pay for such contract, except to the extent that furnishing such copies may be prohibited by government
security regulations. Attached hereto as Schedule B is a complete list of all Government Contracts under which Receivables now exist or may hereafter arise, identified by the names of the contracting parties thereto, the date thereof and the number
identifying the Government Contract or agreement and providing information in the form specified by the Secured Party from time to time regarding the contracting officer, the identity of any sureties and the disbursing officer, whether progress
payments are to be made and the rate thereof, whether the Government Contract or agreement has been fully performed and such other information as the Secured Party may request. A true, complete and correct copy of each such Government Contract
(including all modifications thereto and notice of exercise of options thereunder) now existing has been provided to the Secured Party by the Debtor. The Debtor shall as soon as practicable (but in no event later than five days prior to the date of
execution thereof) notify the Secured Party of any additional Government Contracts, or any renewals or extensions of any Government Contract or the exercise of any options thereunder or modifications thereof, identified by the names of the
contracting parties thereto, the date thereof and the number identifying the Government Contract or agreement and providing information in the form specified by the Secured Party from time to time regarding the contracting officer, the identity of
any sureties and the disbursing officer, whether progress payments are to be made and the rate thereof, and such other information as the Secured Party may request, and a true, complete and correct copy of each such Government Contract, amendment or
modification or exercise of option shall be provided to the Secured Party by the Debtor no later than the date of execution thereof. 

  

	 	(o)	Claims and Disputes. Immediately upon learning thereof, report to the Secured Party any reclamation, return or repossession of goods except returns made in the ordinary course of
business, any claim or dispute asserted by any Account Debtor or other obligor, and any other matter affecting the value and enforceability or collectability of any of the Collateral. In addition, the Debtor shall, at its sole cost and expense
(including attorneys’ fees), settle any and all such claims and disputes and indemnify and protect the Secured Party against any liability, loss or expense arising therefrom or out of any such reclamation, return or repossession of goods,
provided, however, that the Secured Party, if Debtor is not doing so, and if it shall so elect, shall have the right at all times to settle, compromise, adjust or litigate all claims or disputes directly with the Account Debtor or other obligor upon
such terms and conditions as the Secured Party deems advisable and charge all costs and expenses thereof (including reasonable attorneys’ fees) to the Debtor’s account and add them to the principal amount of the Indebtedness.

  

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	 	(p)	Government Contracts Are Binding, Etc. Take the necessary or appropriate steps to ensure that all Government Contracts have been, or if arising hereafter will be, legally awarded
and binding on the parties thereto; no payment has been or will be made by the Debtor, any affiliate, or any person acting on their behalf, to any person that was, is or will be contingent upon the award of any Government Contract in violation of
applicable procurement law or that would otherwise be in violation of applicable procurement law (including, but not limited to, the Federal Acquisition Regulations, the Defense Acquisition Regulations, the Federal Procurement Regulations and the
Armed Services Procurement Regulations); there is no claim that has been asserted by any government agency or authority concerning the award or performance of any Government Contract and the Debtor shall immediately notify the Secured Party of the
assertion of any such claim or the existence of any basis therefor; neither the Debtor nor any director, employee or Affiliate has been debarred or suspended from participation in the award of contracts with the federal government or any state or
local government, or any agency or instrumentality thereof, or is a party to or the subject of any pending or threatened proceeding or investigation relating to debarment or suspension, and the Debtor shall immediately notify the Secured Party of
the occurrence of any of the foregoing or the existence of any basis therefor; and neither the Debtor nor any Affiliate, nor any officer, director or employee of any of them, is permanently or temporarily enjoined or barred from engaging in or
continuing any conduct or practice relating to the conduct of their business, or enjoining or requiring any of them to take any action of any kind relating thereto, and the Debtor shall immediately notify the Secured Party of the occurrence of any
of the foregoing or the existence of any basis therefor. 

  

	 	(q)	No Provisions Prohibiting Assignment of Government Contracts. Take the necessary or appropriate steps to ensure that each Government Contract (i) does not and will not contain
any provision prohibiting assignment thereof as provided herein, (ii) contains a “no set-off” clause or does not permit any set-off against or reduction of the obligation to make payments thereunder for liability of the Debtor to the
government because of re-negotiation, fine, penalty (other than as specifically permitted by the federal Assignment of Claims Act with respect to Government Contracts with the federal government), taxes, social security contributions, or withholding
or failing to withhold taxes, social security contributions or similar amounts, whether arising from or independent of the Government Contract. The Debtor shall promptly notify the Secured Party of any claimed set-off or reduction or the
disallowance of progress payment requests. 

  

	 	(r)	Cost Accounting and Procurement Systems. The Debtor’s cost accounting and procurement systems are and at all times have been, and will continue to be, in compliance with all
applicable requirements. 

  

	 	(s)	Compliance with Assignment Requirements for Government Contracts. The Debtor is now in compliance and hereby covenants and agrees that the Debtor will in the future comply with any
and all of the requirements of Title 31 Section 3727 and Title 31 Section 15 of the United States Code and any similar state or local law and all rules and regulations relating thereto, as amended, where such statutes, rules and
regulations are applicable to a particular Receivable, and shall at all times take all such other action as may be necessary to facilitate and/or ensure perfection of the Secured Party’s security interest in and the assignment to the Secured
Party of any Government Account and Government Contract. 

  

	 	(t)	Information Concerning Government Contracts. At the request of the Secured Party, submit to the Secured Party for the Secured Party’s approval each Government Contract which
the Debtor desires to be included in determining eligible Government Accounts, and provide such other information concerning such Government Contract as the Secured Party may reasonably request. 

  

	 	(u)	Domain Name. Take the necessary or appropriate steps to ensure that the identity and location of the servers used in connection with the Debtor’s domain name and the identity
of the party having control over the domain name server and of the administrative contact with the registry have been disclosed to the Secured Party. The Debtor shall not change the domain name server without notification to the Secured Party. The
Debtor shall maintain the trademark of the domain name by defending against any infringement suits and by policing the trademark. The Debtor shall renew the domain name registration during the loan term. The Debtor shall make all payments to the
domain name registrar necessary to maintain the domain name. 

  

	 	(v)	Account Control Agreements. Debtor shall at all times maintain all Cash Equivalents owned by Debtor on deposit in a Deposit Account or accounts holding securities in Debtor’s
name at Silicon Valley Bank or in a Deposit Account or accounts holding securities at another institution (a “THIRD PARTY INSTITUTION”) covered by an account control agreement in favor of Secured Party (the terms of which shall be
substantially identical to the terms of that certain Control Agreement, dated May 31, 2005, between Debtor and Secured Party, or otherwise acceptable to Secured Party). At any time that the Cash Equivalents or any portion thereof are held in an
account or accounts in one or more Third Party Institutions, the related account control agreement shall provide that Secured Party is to receive monthly account statements, in form and substance acceptable to Secured Party, evidencing that the Cash
Equivalents are maintained in the related account. With respect to each such Deposit Account, Debtor, Secured Party, and each Third Party Institution with which a Deposit Account is maintained, shall enter into a written agreement, granting Secured
Party control of the Deposit Account and providing that, upon an event of default by Debtor, the Third Party Institution will comply with instructions originated by the Secured Party directing disposition of the funds in the Deposit Account without
further consent by Debtor. Such account control agreement may in accordance with the provisions thereof provide terms under which Debtor may remove funds from the Deposit Account; provided all funds in or transferred into the Deposit Account on or
after the effectiveness of this Agreement shall be subject to the security interest granted under this Agreement. 

  

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	 	(w)	Distributions. Debtor shall not (i) pay any dividends or make any distributions on its equity securities; (ii) purchase, redeem, retire, defease or otherwise acquire for
value any of its equity securities (other than repurchases pursuant to the terms of employee stock purchase plans, employee restricted stock agreements or similar arrangements in an aggregate amount not to exceed Fifty Thousand Dollars ($50,000) per
annum); (iii) return any capital to any holder of its equity securities as such; (iv) make any distribution of assets, equity securities, obligations or securities to any holder of its equity securities as such; or (v) set apart any
sum for any such purpose; provided, however, Debtor may pay dividends payable solely in common stock. 

  

	 	(x)	Indebtedness Payments. Debtor shall not (i) prepay, redeem, purchase, defease or otherwise satisfy in any manner prior to the scheduled repayment thereof any Additional
Indebtedness for borrowed money or lease obligations, (ii) amend, modify or otherwise change the terms of any Additional Indebtedness for borrowed money or lease obligations so as to accelerate the scheduled repayment thereof or
(iii) repay any notes to officers, directors or shareholders except as expressly provided for in a duly executed subordination agreement in favor of, and approved by Secured Party. 

  

	 	(y)	Additional Indebtedness. Debtor shall not create, incur, assume or permit to exist any Additional Indebtedness except Permitted Indebtedness. 

  

	 	(z)	Negative Pledge on Intellectual Property. Debtor’s Intellectual Property is, and will remain, free and clear of all liens, claims and encumbrances of any kind whatsoever,
except for Permitted Liens. Debtor shall not sell, transfer, assign, mortgage, pledge, lease, grant a security interest in, or encumber any of its Intellectual Property, or enter into any agreement, document, instrument or other arrangement (except
with or in favor of Secured Party) with any entity which directly or indirectly prohibits or has the effect of prohibiting Debtor from selling, transferring, assigning, mortgaging, pledging, leasing, granting a security interest in or upon, or
encumbering any of Debtor’s Intellectual Property; provided, however, that Debtor may grant non-exclusive licenses with respect to components of Debtor’s Intellectual Property in connection with joint ventures, corporate collaborations and
distribution arrangements in the ordinary course of business. 

  

	4.	INSURANCE. 

  

	 	(a)	Risk of Loss. Debtor shall at all times bear the entire risk of any loss, theft, damage to, or destruction of, any of the Collateral from any cause whatsoever.

  

	 	(b)	Insurance Requirements. Debtor agrees to maintain general liability insurance and to keep the Collateral insured against loss or damage by fire and extended coverage perils, theft,
burglary, risk of loss by collision (for any or all Collateral which are vehicles) and such other risks as Secured Party may reasonably require. The liability insurance coverage shall be in an amount standard for companies similar to Debtor in
Debtor’s industry in Debtor’s geographic region. The property insurance coverage shall be in an amount no less than the full replacement value of the Collateral. All insurance policies shall be in a form, with companies and with deductible
amounts, acceptable to Secured Party. Debtor shall deliver to Secured Party policies or certificates of insurance evidencing such coverage. Each policy shall name Secured Party as a loss payee and an additional insured, shall provide for coverage to
Secured Party regardless of the breach by Debtor of any warranty or representation made therein, shall not be subject to co-insurance, and shall provide that coverage may not be canceled or altered by the insurer except upon thirty (30) days
prior written notice to Secured Party. Debtor appoints Secured Party as its attorney-in-fact to make proof of loss, claim for insurance and adjustments with insurers, and to receive payment of and execute or endorse all documents, checks or drafts
in connection with insurance payments. Secured Party shall not act as Debtor’s attorney-in-fact unless Debtor is in default. Proceeds of insurance shall be applied, at the option of Secured Party, to repair or replace the Collateral or to
reduce any of the Indebtedness. 

  

	5.	REPORTS. 

  

	 	(a)	Notice of Events. Debtor shall promptly notify Secured Party of (i) any change in the name of Debtor, (ii) any change in the state of its incorporation or registration,
(iii) any relocation of its chief executive offices, (iv) any of the Collateral being lost, stolen, missing, destroyed, materially damaged or worn out, (v) any lien, claim or encumbrance other than Permitted Liens attaching to or
being made against any of the Collateral, or (vi) any occurrence of any default pursuant to Section 7 herein. 

  

	 	(b)	 Financial Statements, Reports and Certificates. Debtor will deliver to Secured Party within one hundred twenty (120) days of the close of each fiscal year of
Debtor, Debtor’s complete financial statements including a balance sheet, income statement, statement of shareholders’ equity and statement of cash flows, each prepared in accordance with generally accepted accounting principles
consistently applied, certified by a recognized firm of certified public accountants satisfactory to Secured Party. Debtor will deliver to Secured Party copies of Debtor’s quarterly financial statements including a balance sheet, income
statement and statement of cash flows, each prepared by Debtor in accordance with generally accepted accounting principles consistently applied by Debtor and certified by Debtor’s president or chief financial officer, within forty-five
(45) days after the close of each of Debtor’s fiscal quarter. Debtor will deliver to Secured Party copies of all Forms 10-K and 10-Q, if any, within 30 days after the 

  

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dates on which they are filed with the Securities and Exchange Commission. Debtor will deliver to Secured Party copies of Debtor’s monthly financial
statements including a balance sheet and income statement, each prepared by Debtor in accordance with generally accepted accounting principles consistently applied by Debtor and certified by Debtor’s president or chief financial officer, within
thirty (30) days after the close of each month. Concurrently with delivery of the foregoing information, and from time to time promptly upon request of Secured Party, Debtor will deliver to Secured Party a Compliance Certificate substantially
consistent with the form of the document attached hereto as Schedule C. Debtor will deliver to Secured Party promptly upon request of Secured Party, in form satisfactory to Secured Party, such other and additional information as Secured Party may
reasonably request from time to time. 

  

	6.	FURTHER ASSURANCES. 

  

	 	(a)	Further Assurances Regarding Security Interests. Debtor shall, upon request of Secured Party, furnish to Secured Party such further information, execute and deliver to Secured Party
such documents and instruments (including, without limitation, Uniform Commercial Code financing statements) and shall do such other acts and things as Secured Party may at any time reasonably request relating to the perfection or protection of the
security interest created by this Agreement or for the purpose of carrying out the intent of this Agreement. Without limiting the foregoing, Debtor shall cooperate and do all acts deemed necessary or advisable by Secured Party to continue in Secured
Party a perfected first security interest in the Collateral, and shall obtain and furnish to Secured Party any subordinations, releases, landlord waivers, lessor waivers, mortgagee waivers, or control agreements, and similar documents as may be from
time to time reasonably requested by, and in form and substance satisfactory to, Secured Party. 

  

	 	(b)	Authorization To File Financing Statements. Debtor shall perform any and all acts requested by the Secured Party to establish, maintain and continue the Secured Party’s
security interest and liens in the Collateral, including but not limited to, executing or authenticating financing statements and such other instruments and documents when and as reasonably requested by the Secured Party. Debtor hereby authorizes
Secured Party through any of Secured Party’s employees, agents or attorneys to file any and all financing statements, including, without limitation, any original filings, continuations, transfers or amendments thereof required to perfect
Secured Party’s security interest and liens in the Collateral under the UCC without authentication or execution by Debtor. Debtor hereby irrevocably authorizes the Secured Party at any time and from time to time to file in any filing office in
any Uniform Commercial Code jurisdiction any initial financing statement(s) and amendments thereto that (a) indicate the Collateral (i) as all assets of the Debtor or words of similar effect, regardless of whether any particular asset
comprised in the Collateral falls within the scope of Article 9 of the Uniform Commercial Code of the State or such jurisdiction, or (ii) as being of an equal or lesser scope or with greater detail, and (b) provide any other information
required by part 5 of Article 9 of the Uniform Commercial Code of the State or such other jurisdiction for the sufficiency or filing office acceptance of any financing statement or amendment, including (i) whether the Debtor is an organization,
the type of organization and any organization identification number issued to the Debtor, and (ii) in the case of a financing statement filed as a fixture filing, a sufficient description of real property to which the Collateral relates. The
Debtor agrees to furnish any such information to the Secured Party promptly upon the Secured Party’s request. 

  

	 	(c)	Indemnification. Debtor shall indemnify and defend the Secured Party, its successors and assigns, and their respective directors, officers and employees, from and against all
claims, actions and suits (including, without limitation, related attorneys’ fees) of any kind whatsoever arising, directly or indirectly, in connection with any of the Collateral or the Debt Documents. 

  

	7.	DEFAULT AND REMEDIES. 

  

	 	(a)	Defaults. Debtor shall be in default under this Agreement and each of the other Debt Documents if any one of the following should occur: 

  

	 	(i)	Debtor breaches its obligation to pay when due any installment or other amount due or coming due under any of the Debt Documents; 

  

	 	(ii)	Debtor, without the prior written consent of Secured Party, attempts to or does sell, rent, lease, license, mortgage, grant a security interest in, or otherwise transfer or
encumber, or allow Liens (except for Permitted Liens) upon, any of the Collateral (other than the sale of goods in the ordinary course of business) and Debtor fails to cure such breach within thirty (30) days after the occurrence thereof;

  

	 	(iii)	Debtor breaches any of its insurance obligations under Section 4; 

  

	 	(iv)	Debtor breaches any of its obligations under Sections 2(v) or 2(w) or Sections 3(v), (w), (x), (y) or (z); 

  

	 	(v)	Debtor breaches any of its other non-payment obligations under any of the Debt Documents and fails to cure that breach within thirty (30) days after it has occurred;

  

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	 	(vi)	Any warranty, representation or statement made by Debtor in any of the Debt Documents or otherwise in connection with any of the Indebtedness shall be false or misleading in any
material respect; 

  

	 	(vii)	Any of the Collateral is subjected to attachment, execution, levy, seizure or confiscation in any legal proceeding or otherwise, or if any legal or administrative proceeding is
commenced against Debtor or any of the Collateral, which in the good faith judgment of Secured Party subjects any of the Collateral to a material risk of attachment, execution, levy, seizure or confiscation and no bond is posted or protective order
obtained to negate such risk; 

  

	 	(viii)	Debtor breaches or is in default under any other agreement between Debtor and Secured Party; 

  

	 	(ix)	Debtor or any guarantor or other obligor for any of the Indebtedness (collectively “GUARANTOR”) dissolves, terminates its existence, becomes insolvent or ceases to do
business as a going concern; 

  

	 	(x)	If Debtor or any Guarantor is a natural person, and Debtor or any such Guarantor dies or becomes incompetent; 

  

	 	(xi)	A receiver is appointed for all or of any part of the property of Debtor or any Guarantor, or Debtor or any Guarantor makes any assignment for the benefit of creditors;

  

	 	(xii)	Debtor or any Guarantor files a petition under any bankruptcy, insolvency or similar law, or any such petition is filed against Debtor or any Guarantor and is not dismissed within
forty-five (45) days; 

  

	 	(xiii)	Debtor’s improper filing of an amendment or termination statement relating to a filed financing statement describing the Collateral and Debtor fails to cure such breach within
thirty (30) days after the occurrence thereof; 

  

	 	(xiv)	Debtor shall merge with or consolidate into any other entity or sell all or substantially all of its assets or in any manner terminate its existence; 

  

	 	(xv)	If Debtor is a privately held corporation, more than 50% of Debtor’s voting capital stock, or effective control of Debtor’s voting capital stock, issued and outstanding
from time to time, is not retained by the holders of such stock on the date the Agreement is executed; provided, however, this provision shall not apply to an equity financing of Debtor; 

  

	 	(xvi)	If Debtor is a publicly held corporation, there shall be a change in the ownership of Debtor’s stock such that Debtor is no longer subject to the reporting requirements of the
Securities Exchange Act of 1934 or no longer has a class of equity securities registered under Section 12 of the Securities Act of 1933; 

  

	 	(xvii)	Debtor defaults under any agreement to pay Additional Indebtedness or any other financing arrangement between Debtor and a third party and Debtor fails to cure such breach within
thirty (30) days after the occurrence thereof; 

  

	 	(xviii)	[omitted intentionally] 

  

	 	(xix)	Secured Party shall have determined in its sole and good faith judgment that there has been a material adverse change in the financial condition, business, operations, prospects,
product development, technology, or business or contractual relations with third parties of Debtor from the date hereof, or a change or event shall have occurred which would impair the ability of Debtor to perform its obligations hereunder or under
any of the other financing agreements to which it is a party or of Secured Party to enforce the Indebtedness or realize upon the Collateral. 

  

	 	(b)	Acceleration. If Debtor is in default, the Secured Party, at its option, may declare any or all of the Indebtedness to be immediately due and payable, without demand or notice to
Debtor or any guarantor (provided that if there is a default as a result of a bankruptcy or insolvency all Indebtedness shall become immediately due and payable without any action by Secured Party). The accelerated obligations and liabilities shall
bear interest (both before and after any judgment) until paid in full at the Default Rate. 

  

	 	(c)	 Rights and Remedies. Secured Party shall have all of the rights and remedies of a Secured Party under the Uniform Commercial Code, and under any other applicable
law. Without limiting the foregoing, if Debtor is in default, Secured Party shall have the right to (i) notify any Account Debtor of Debtor or any obligor on any instrument which constitutes part of the Collateral to make payment to the Secured
Party, (ii) with or without legal process, enter any premises where the Collateral may be and take possession of and remove the Collateral from the premises or store it on the premises, (iii) sell the Collateral at public or private sale,
in whole or in part, and have the right to bid and purchase at said sale, (iv) to instruct the bank maintaining any Deposit Account to transfer the funds in the Deposit Account to any account of the Secured Party, or (v) lease or otherwise
dispose of all or part of the Collateral, applying proceeds from such disposition to the obligations then in default. If Debtor is in default and if 

  

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requested by Secured Party, Debtor shall promptly assemble the Collateral and make it available to Secured Party at a place to be designated by Secured
Party, which is reasonably convenient to both parties. If Debtor is in default, Secured Party may also render any or all of the Collateral unusable at the Debtor’s premises and may dispose of such Collateral on such premises without liability
for rent or costs. Any notice that Secured Party is required to give to Debtor under the Uniform Commercial Code of the time and place of any public sale or the time after which any private sale or other intended disposition of the Collateral is to
be made shall be deemed to constitute reasonable notice if such notice is given to the last known address of Debtor at least five (5) days prior to such action. Upon the occurrence and during the continuation of a default, Debtor hereby
appoints Secured Party as Debtor’s attorney-in-fact, with full authority in Debtor’s place and stead and in Debtor’s name or otherwise, from time to time in Secured Party’s sole and arbitrary discretion, to take any action and to
execute any instrument which Secured Party may deem necessary or advisable to accomplish the purpose of this Agreement. Secured Party is granted a non-exclusive royalty free license to use Debtor’s Intellectual Property in connection with
Secured Party’s disposition of Collateral in the exercise of Secured Party’s rights or remedies hereunder. 

  

	 	(d)	Application of Proceeds. The proceeds and/or avails of the Collateral, or any part thereof, and the proceeds and the avails of any remedy hereunder (as well as any other amounts of
any kind held by Secured Party, at the time of or received by Secured Party after the occurrence of a default hereunder) shall be paid to and applied as follows: 

  

	 	a.	First, to the payment of out-of-pocket costs and expenses, including all amounts expended to preserve the value of the Collateral, all costs of repossession, storage, and
disposition including without limitation reasonable attorneys’, appraisers’, and auctioneers’ fees, of foreclosure or suit, if any, and of such sale and the exercise of any other rights or remedies, and of all proper fees, expenses,
liability and advances, including reasonable legal expenses and reasonable attorneys’ fees, incurred or made hereunder by Secured Party, including without limitation, Secured Party’s Expenses; 

  

	 	b.	Second, to the payment to Secured Party of the amount then owing or unpaid on the Loans for scheduled payments, any accrued and unpaid interest, and all other Indebtedness
(provided, however, if such proceeds shall be insufficient to pay in full the whole amount so due, owing or unpaid upon the Loans, then to the unpaid interest thereon, then to the outstanding principal amount of the Loans, and then to the payment of
other amounts then payable to Secured Party under any of the Debt Documents or otherwise); and 

  

	 	c.	Third, to the payment of the surplus, if any, to Debtor, its successors and assigns, or to whomsoever may be lawfully entitled to receive the same. 

  

	 	(e)	Fees and Costs. Debtor agrees to pay all reasonable attorneys’ fees and other costs incurred by Secured Party in connection with the enforcement, assertion, defense or
preservation of Secured Party’s rights and remedies under this Agreement, or if prohibited by law, such lesser sum as may be permitted. Debtor further agrees that such fees and costs shall constitute Indebtedness. 

  

	 	(f)	Remedies Cumulative. Secured Party’s rights and remedies under this Agreement or otherwise arising are cumulative and may be exercised singularly or concurrently. Neither the
failure nor any delay on the part of the Secured Party to exercise any right, power or privilege under this Agreement shall operate as a waiver, nor shall any single or partial exercise of any right, power or privilege preclude any other or further
exercise of that or any other right, power or privilege. SECURED PARTY SHALL NOT BE DEEMED TO HAVE WAIVED ANY OF ITS RIGHTS UNDER THIS AGREEMENT OR UNDER ANY OTHER AGREEMENT, INSTRUMENT OR PAPER SIGNED BY DEBTOR UNLESS SUCH WAIVER IS EXPRESSED IN
WRITING AND SIGNED BY SECURED PARTY. A waiver on any one occasion shall not be construed as a bar to or waiver of any right or remedy on any future occasion. 

  

	 	(g)	WAIVER OF JURY TRIAL. DEBTOR AND SECURED PARTY UNCONDITIONALLY WAIVE THEIR RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF THIS AGREEMENT, ANY OF
THE OTHER DEBT DOCUMENTS, ANY OF THE INDEBTEDNESS SECURED HEREBY, ANY DEALINGS BETWEEN DEBTOR AND SECURED PARTY RELATING TO THE SUBJECT MATTER OF THIS TRANSACTION OR ANY RELATED TRANSACTIONS, AND/OR THE RELATIONSHIP THAT IS BEING ESTABLISHED BETWEEN
DEBTOR AND SECURED PARTY. THE SCOPE OF THIS WAIVER IS INTENDED TO BE ALL ENCOMPASSING OF ANY AND ALL DISPUTES THAT MAY BE FILED IN ANY COURT. THIS WAIVER IS IRREVOCABLE. THIS WAIVER MAY NOT BE MODIFIED EITHER ORALLY OR IN WRITING. THE WAIVER ALSO
SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS AGREEMENT, ANY OTHER DEBT DOCUMENTS, OR TO ANY OTHER DOCUMENTS OR AGREEMENTS RELATING TO THIS TRANSACTION OR ANY RELATED TRANSACTION. THIS AGREEMENT MAY BE
FILED AS A WRITTEN CONSENT TO A TRIAL BY THE COURT. 

  

	8.	MISCELLANEOUS. 

  

	 	(a)	 Assignment. This Agreement, any Note and/or any of the other Debt Documents may be assigned, in whole or in part, by Secured Party without notice to Debtor, and
Debtor agrees not to assert against any such assignee, or assignee’s assigns, any defense, set-off, recoupment claim or counterclaim which Debtor has or may at any time have against Secured Party for any reason whatsoever. Debtor agrees that if
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written notice of an assignment from Secured Party, Debtor will pay all amounts payable under any assigned Debt Documents to such assignee or as instructed
by Secured Party. Debtor also agrees to confirm in writing receipt of the notice of assignment as may be reasonably requested by Secured Party or assignee. 

  

	 	(b)	Notices. All notices to be given in connection with this Agreement shall be in writing, shall be addressed to the parties at their respective addresses set forth in this Agreement
(unless and until a different address may be specified in a written notice to the other party), and shall be deemed given (i) on the date of receipt if delivered in hand or by facsimile transmission, (ii) on the next business day after
being sent by express mail, and (iii) on the fourth business day after being sent by regular, registered or certified mail. As used herein, the term “business day” shall mean and include any day other than Saturdays, Sundays, or other
days on which commercial banks in New York, New York are required or authorized to be closed. 

  

	 	(c)	Correction of Errors. Upon written notice to Debtor, Secured Party may correct patent errors and fill in all blanks in this Agreement or in any Note consistent with the agreement of
the parties. 

  

	 	(d)	Time is of the Essence. Time is of the essence of this Agreement. This Agreement shall be binding, jointly and severally, upon all parties described as the “Debtor” and
their respective heirs, executors, representatives, successors and assigns, and shall inure to the benefit of Secured Party, its successors and assigns. 

  

	 	(e)	Entire Agreement. This Agreement and the Debt Documents constitute the entire agreement between the parties with respect to the subject matter of this Agreement and supersede all
prior understandings (whether written, verbal or implied) with respect to such subject matter. THIS AGREEMENT AND THE DEBT DOCUMENTS SHALL NOT BE CHANGED OR TERMINATED ORALLY OR BY COURSE OF CONDUCT, BUT ONLY BY A WRITING SIGNED BY BOTH PARTIES.
Section headings contained in this Agreement have been included for convenience only, and shall not affect the construction or interpretation of this Agreement. This Agreement is the result of negotiations between and has been reviewed by each of
Debtor and Secured Party executing this Agreement as of the date hereof and their respective counsel; accordingly, this Agreement shall be deemed to be the product of the parties hereto, and no ambiguity shall be construed in favor of or against
Debtor or Secured Party. 

  

	 	(f)	Termination of Agreement. This Agreement shall continue in full force and effect until all of the Indebtedness has been indefeasibly paid in full to Secured Party or its assignee;
provided, that Debtor’s indemnity obligations set forth in Section 6(c) shall survive until all applicable statute of limitations periods with respect to actions that may be brought against Secured Party have run ; provided further that,
Debtor’s obligations under Section 2(v) shall survive indefinitely until, by their terms, they are no longer operative. The surrender, upon payment or otherwise, of any Note or any of the other documents evidencing any of the Indebtedness
shall not affect the right of Secured Party to retain the Collateral for such other Indebtedness as may then exist or as it may be reasonably contemplated will exist in the future. This Agreement shall automatically be reinstated if Secured Party is
ever required to return or restore the payment of all or any portion of the Indebtedness (all as though such payment had never been made). Secured Party shall, at Debtor’s sole cost and expense, execute such further documents and take such
further actions as may be reasonably necessary to effect the release of its security interests contemplated by this paragraph, including duly executing and delivering termination statements for filing in all relevant jurisdictions under the Code.

  

	 	(g)	CHOICE OF LAW. DEBTOR AGREES THAT SECURED PARTY AND/OR ITS SUCCESSORS AND ASSIGNS SHALL HAVE THE OPTION BY WHICH STATE LAWS THIS AGREEMENT SHALL BE GOVERNED AND CONSTRUED:
(A) THE LAWS OF THE COMMONWEALTH OF VIRGINIA; OR (B) IF COLLATERAL HAS BEEN PLEDGED TO SECURE THE LIABILITIES, THEN BY THE LAWS OF THE STATE OR STATES WHERE THE COLLATERAL IS LOCATED, AT SECURED PARTY’S OPTION. THIS CHOICE OF STATE
LAWS IS EXCLUSIVE TO THE SECURED PARTY. DEBTOR SHALL NOT HAVE ANY OPTION TO CHOOSE THE LAWS BY WHICH THIS AGREEMENT SHALL BE GOVERNED. DEBTOR ACKNOWLEDGES THAT THIS AGREEMENT IS BEING SIGNED BY THE SECURED PARTY IN PARTIAL CONSIDERATION OF SECURED
PARTY’S RIGHT TO ENFORCE IN THE JURISDICTION STATED ABOVE. DEBTOR CONSENTS TO JURISDICTION IN THE COMMONWEALTH OF VIRGINIA OR THE STATE IN WHICH ANY COLLATERAL IS LOCATED AND VENUE IN ANY FEDERAL OR STATE COURT IN THE COMMONWEALTH OF VIRGINIA
OR THE STATE IN WHICH COLLATERAL IS LOCATED FOR SUCH PURPOSES AND WAIVES ANY AND ALL RIGHTS TO CONTEST SAID JURISDICTION AND VENUE AND ANY OBJECTION THAT SAID COUNTY IS NOT CONVENIENT. DEBTOR WAIVES ANY RIGHTS TO COMMENCE ANY ACTION AGAINST SECURED
PARTY IN ANY JURISDICTION EXCEPT VIRGINIA, OR IF SECURED PARTY CHOOSES TO LITIGATE IN A STATE WHERE COLLATERAL IS LOCATED THEN IN SUCH COUNTY AND STATE. 

  

	 	(h)	Limitation of Liability. The Secured Party shall not, under any circumstances, be liable for any error or omission or delay of any kind occurring in the settlement, collection or
payment of any Receivables or any instrument received in payment thereof or for any damage resulting therefrom. The Secured Party is authorized to accept the return of the goods represented by any of the Receivables, without notice to or consent by
the Debtor, or without discharging or in any manner affecting the Loan. 

  

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	 	(i)	Notification to Account Debtors. Secured Party shall have the right at any time to notify any Account Debtor of the Secured Party’s security interest in the Receivables and,
after an event of default by Debtor, to require payments to be made directly to the Secured Party. To facilitate direct collection, the Debtor hereby appoints the Secured Party and any officer or employee of the Secured Party, as the Secured Party
may from time to time designate, as attorney-in-fact for the Debtor to, upon an event of default, (a) receive, open and dispose of all mail addressed to the Debtor and take therefrom any payments on or proceeds of Receivables; (b) take
over the Debtor’s post office boxes or make such other arrangements, in which the Debtor shall cooperate, to receive the Debtor’s mail, including notifying the post office authorities to change the address for delivery of mail addressed to
the Debtor to such address as the Secured Party shall designate; (c) endorse the name of the Debtor in favor of the Secured Party upon any and all checks, drafts, money orders, notes, acceptances or other evidences of payment or Collateral that
may come into the Secured Party’s possession; (d) sign and endorse the name of the Debtor on any invoice or bill of lading relating to any of the Receivables, on verifications of Receivables sent to any Account Debtor, to drafts against
any Account Debtor, to assignments of Receivables, and to notices to any Account Debtor; and (e) do all acts and things necessary to carry out this Agreement and the transactions contemplated hereby, including signing the name of the Debtor on
any instruments required by law in connection with the transactions contemplated hereby and on financing statements as permitted by the Virginia Uniform Commercial Code. The Debtor hereby ratifies and approves all acts of such attorneys-in-fact, and
neither the Secured Party nor any other such attorney-in-fact shall be liable for any acts of commission or omission, or for any error of judgment or mistake of fact or law of any such attorney-in-fact. This power, being coupled with an interest, is
irrevocable so long as the Loan remains unsatisfied, or any Debt Document remains effective, as solely determined by the Secured Party. 

  

	 	(j)	Loss, Depreciation or Other Damage. The Secured Party shall not be liable for or prejudiced by any loss, depreciation or other damage to Receivables or other Collateral unless
caused by the Secured Party’s willful and malicious act, and the Secured Party shall have no duty to take any action to preserve or collect any Receivable or other Collateral. 

  

	 	(k)	Demand; Protest. Debtor waives demand, protest, notice of protest, notice of default or dishonor, notice of payment and nonpayment, notice of any default, nonpayment at maturity,
release, compromise, settlement, extension, or renewal of accounts, documents, instruments, chattel paper, and guarantees at any time held by Secured Party on which Debtor may in any way be liable. 

  

	9.	DEFINITIONS. 

 As used herein, the following terms, when
initial capital letters are used, shall have the respective meanings set forth below. In addition, all terms defined in the Code shall have the meanings given therein unless otherwise defined herein. 
 Defined Terms. As used in this Agreement, the following terms shall have the following meanings, unless the context otherwise requires: 
 “ACCOUNT COLLATERAL” has the meaning given such capitalized term in Section 1. 
 “ACCOUNT DEBTOR” shall mean the Account Debtor or any customer of the Debtor who is obligated or indebted to the Debtor with respect to any of
the Receivables and/or the prospective purchaser with respect to any contract right, and/or any party or organization who enters into or proposes to enter into any contract or other arrangement with the Debtor pursuant to which the Debtor is to
deliver any personal property or perform any service. 
 “ADDITIONAL INDEBTEDNESS” means, with respect to Debtor or any of its
subsidiaries, the aggregate amount of, without duplication, (a) all obligations of such Person for borrowed money, (b) all obligations of such Person evidenced by bonds, debentures, notes or other similar instruments, (c) all
obligations of such Person to pay the deferred purchase price of property or services (excluding trade payables aged less than one hundred eighty (180) days), (d) all capital lease obligations of such Person, (e) all obligations or
liabilities of others secured by a Lien on any asset of such Person, whether or not such obligation or liability is assumed, (f) all obligations or liabilities of others guaranteed by such Person, and (g) any other obligations or
liabilities which are required by GAAP to be shown as debt on the balance sheet of such Person. Unless otherwise indicated, the term “ADDITIONAL INDEBTEDNESS” shall include all Indebtedness of Debtor and all of its subsidiaries.

 “AFFILIATE” of a Person is a Person that owns or controls directly or indirectly the Person, any Person that controls or is
controlled by or is under common control with the Person, and each of that Person’s senior executive officers, directors, partners and, for any Person that is a limited liability company, that Person’s managers and members. 
 A/R FACILITY” has the meaning given such capitalized term in Section 1. 
 “CASH EQUIVALENTS” means the sum outstanding, at any one time, of (i) all cash (in United States dollars) owned by Debtor at such time plus
(ii) the fair market value of all cash equivalents and short term investments (as those terms are defined by GAAP) owned by Debtor at such time. 
 “CODE” means the Virginia Uniform Commercial Code (including revised Article 9 thereof). 
 “COLLATERAL” shall mean all personal property and fixtures of the Debtor, including, but not limited to all of the Receivables, Payments, accounts, the Deposit Account or accounts holding securities, contract rights, instruments,
documents, chattel paper (including tangible and electronic chattel paper), payment intangibles, commercial tort claims, health-care-insurance receivables, instruments, investment property, supporting obligations and general intangibles now owned or
hereafter acquired by the Debtor and all goods, equipment, general intangibles and property of the Debtor described below which is now owned or hereafter acquired by the Debtor, wherever located (including items of Collateral located outside the

  

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continental United States); all deposit accounts (including all signature cards, account agreements and other documents relating to deposit accounts) and
other obligations or indebtedness owed to the Debtor from whatever source arising; letter of credit rights; all rights of the Debtor to receive any payment in money or kind; all Inventory; all Equipment; all of the Debtor’s rights as an unpaid
seller, including stoppage in transit, detinue and reclamation; all guarantees, or other agreements or property securing or relating to any of the items referred to above, or acquired for the purpose of securing and enforcing any of such items; all
books of account and documents related thereto; all customer lists and other documents containing the names, addresses and other information regarding the Debtor’s customers, subscribers or those to whom the Debtor provides any services;
computer tapes, programs, discs and other material, media or documents relating to the recording, billing or analyzing of any of the above; all computers, word processors, printers, switches, interfaces, source codes, mask works, software, web
servers, website service contracts, internet connection contract or line lease, website hosting service contract, website license agreements, back-up copies of website content, contracts with website advertisers, scripts, codes or Active-X controls,
technology escrow agreements, website content development agreements, all rights, of whatever form, in and to domain names, instructional material, and connectors and all parts, accessories, additions, substitutions, or options together with all
property or equipment used in connection with any of the above or which are used to operate or cause to operate any features, special applications, format controls, options or software of any or all of the above-mentioned items; whether now owned or
existing or hereafter acquired or arising, all income, royalties and other proceeds; contractual rights, literary rights, all amounts received as an award in or settlement of a suit in damages, proceeds of loans, interests in joint ventures or
general or limited partnerships, the sale by the Debtor of any of the foregoing and all proceeds (cash and non-cash) of the foregoing; proceeds of property received wholly or partly in trade or exchange for the Collateral and all rents, revenues,
issues, profits and proceeds in any form, including cash, insurance proceeds, distributions on stock, negotiable instruments and other evidences of indebtedness, chattel paper, security agreements and other documents arising from the sale, lease,
license, encumbrance, collection of, or any other temporary or permanent disposition of, the Collateral or any interest therein. Notwithstanding the foregoing, the term Collateral shall not include any Intellectual Property; provided, however, the
Collateral shall include all accounts, license and royalty fees and other revenues, proceeds, or income arising out of or relating to the Intellectual Property (the “EXCLUDED PROPERTY”). The Debtor acknowledges and agrees that, in applying
the law of any jurisdiction that at any time enacts all or substantially all of the uniform provisions of Revised Article 9 of the Uniform Commercial Code (1999 Official Text), the foregoing Collateral description covers all assets of the Debtor
other than the Excluded Property. The Secured Party may at any time and from time to time file, pursuant to the provisions of this Agreement, financing and continuation statements and amendments thereto reflecting the same. Notwithstanding the
foregoing, the Collateral shall not include an escrow deposit for Zeilstra Beheer B.V. in the approximate amount of 6,000 Euros, which amount may be increased annually, but shall in no event exceed 10,000 Euros 
 “CONSIGNEE” has the meaning given such capitalized term in Section 3(k). 
 “DEBT DOCUMENTS” has the meaning given such capitalized term in Section 2(b). 
 “DEFAULT RATE” is the lower of eighteen percent (18%) per annum or the maximum rate not prohibited by applicable law. 
 “DEPOSIT ACCOUNT” means a demand, time, savings, passbook, or similar account maintained with a bank. 
 “EQUIPMENT” shall mean (a) all goods and equipment of the Debtor of every type and description, now owned and hereafter acquired and
wherever located, including, without limitation, all imbedded software, machinery, motor vehicles and other rolling stock, furniture, furnishings, tools, dies, fittings, accessories, all substitutions therefor, leasehold improvements, fixtures, and
materials and supplies relating to any of the foregoing; (b) all present and future documents of title and trust receipts relating to any of the foregoing; (c) all present and future rights, claims and causes of action of Debtor in
connection with purchases of (or contracts for the purchase of), or warranties relating to, or damages to, goods held or to be held by the Debtor as equipment; (d) all present and future warranties, manuals and other written materials (and
packaging thereof or relating thereto) relating to any of the foregoing; and (e) all present and future general intangibles of the Debtor in any way relating to any of the foregoing. 
 “GOVERNMENT ACCOUNTS” shall mean all accounts arising out of any Government Contract. 
 “GOVERNMENT CONTRACT” shall mean any contract between the Debtor and the United States Government, any state or local government or any agency
thereof, and all amendments thereto. 
 “INDEBTEDNESS” has the meaning given such capitalized term in Section 1. 
 “INTELLECTUAL PROPERTY” shall mean (a) all of the Debtor’s right, title and interest, whether now owned or existing or hereafter
acquired or arising, in and to all domestic and foreign copyrights, copyright registrations and copyright applications, whether or not registered or filed with any governmental authority, together with (i) all renewals thereof, (ii) all
present and future rights of the Debtor under all present and future license agreements relating thereto, whether the Debtor is licensee or licensor thereunder, (iii) all income, royalties, damages and payments now or hereafter due and/or
payable to the Debtor thereunder or with respect thereto, including, without limitation, damages and payments for past, present or future infringements thereof, (iv) all of the Debtor’s present and future claims, causes of action and
rights to sue for past, present or future infringements thereof, and (v) all rights corresponding thereto throughout the world (collectively “COPYRIGHT RIGHTS”); (b) all of the Debtor’s right, title and interest, whether now
owned or existing or hereafter acquired or arising, in and to all United States and foreign patents, and pending and abandoned United States and foreign patent applications, including, without limitation, the inventions and improvements described or
claimed therein, together with(i) any reissues, divisions, continuations, certificates of re-examination, extensions and continuations-in-part thereof, (ii) all present and future rights of the Debtor under all present and future license
agreements relating thereto, whether the Debtor is licensee or licensor thereunder, (iii) all income, royalties, damages and payments now or hereafter due and/or payable to the Debtor thereunder or with respect thereto, including, without
limitation, damages and payments for past, present or future infringements thereof, (iv) all of the Debtor’s present and future claims, causes of action and rights to sue for past, present or future infringements thereof, and (v) all
rights corresponding thereto throughout the world (collectively “PATENT RIGHTS”); (c) all of the Debtor’s right, title and interest, whether now owned or existing or hereafter acquired or arising, in and to all domestic and
foreign trademarks, trademark registrations, trademark applications and trade names, whether or not registered or filed with any governmental authority, together with (i) all renewals thereof, (ii) all present and future rights of the
Debtor under all present and future license agreements relating thereto, whether the Debtor is licensee or licensor thereunder, (iii) all income, royalties, damages and payments now or hereafter due and/or payable to the Debtor thereunder or
with respect thereto, including, without limitation, damages and payments for past, present or future infringements thereof, (iv) all of the Debtor’s present and future claims, causes of action and rights to sue for past, present or future
infringements thereof, and (v) all rights corresponding thereto throughout the world (collectively “TRADEMARK RIGHTS”); (d) all present and future licenses and license agreements of the Debtor, and all rights of the Debtor under
or in connection therewith, whether the Debtor is licensee or licensor thereunder, including, without limitation, any present or future franchise agreements under which the Debtor is franchisee or franchisor, together with (i) all renewals
thereof, (ii) all income, royalties, damages and payments now or hereafter due and/or payable to the Debtor thereunder or with 

  

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respect thereto, including, without limitation, damages and payments for past, present or future infringements thereof, (iii) all claims, causes of
action and rights to sue for past, present or future infringements thereof, and (iv) all rights corresponding thereto throughout the world (collectively “LICENSE RIGHTS”); (e) all present and future trade secrets of the Debtor;
and (f) all other present and future intellectual property of the Debtor. 
 “INVENTORY” shall mean and include (a) all
goods now owned or hereafter acquired by the Debtor, which are held for sale or lease by the Debtor or are furnished or to be furnished by the Debtor under contracts of service, (b) all raw materials, work in process, finished goods, packaging
materials, and other materials and supplies of every kind used or consumed in connection with the manufacture, production, packing, shipping, advertising or sale of such goods, (c) all proceeds and products from the sale or other disposition of
such goods, including all goods returned, repossessed, or acquired by the Debtor by way of substitution or replacement, and all additions and accessions thereto, and all documents and instruments (as those terms are defined in the Uniform Commercial
Code) covering such goods; (d) all the Debtor’s rights as an unpaid seller, including stoppage in transit, detinue and reclamation; and (e) all of the above owned by the Debtor or in which the Debtor now has or in which the Debtor may
hereafter acquire an interest, whether in transit or in the Debtor’s constructive or actual possession or held by the Debtor or others for the Debtor’s account (including any of the above held on consignment), including, without
limitation, all of the above which may be located on the Debtor’s premises or upon the premises of any carriers, forwarding agents, truckers, warehousemen, vendors, selling agents, finishers, converters or other third parties who may have
possession, temporary or otherwise, thereof. 
 “LIEN(S)” shall mean any voluntary or involuntary mortgage, pledge, deed of trust,
assignment, security interest, encumbrance, hypothecation, lien, or charge of any kind (including any conditional sale or other title retention agreement, any financing lease having substantially the same economic effect as any of the foregoing, and
the filing of, or agreement to give, any financing statement under the Uniform Commercial Code or comparable law of any jurisdiction). 
 “LOAN” means an advance of credit by Secured Party to Debtor. 
 “NOTE” has the meaning given such capitalized
term in Section 1. 
 “PAYMENT” or “PAYMENTS” shall mean any check, draft, cash or any other remittance or credit in
payment or on account of any or all of the Receivables and the cash proceeds of any returned, rejected or repossessed goods, the sale or lease of which gave rise to a Receivable. 
 “PERMITTED INDEBTEDNESS” means and includes: (i) Indebtedness of Debtor to Secured Party, (ii) Additional Indebtedness arising from
the endorsement of instruments in the ordinary course of business, (iii) Additional Indebtedness existing on the date hereof and set forth in Schedule B, (iv) Subordinated Indebtedness, and (v) Additional Indebtedness in the form of
the A/R Facility under the terms as set forth in Section 1 and which is secured solely by Debtor’s Account Collateral, up to $500,000 cumulative aggregate Indebtedness in the first 24 months and up to $600,000 cumulative aggregate
Indebtedness thereafter for Debtor to incur debt from third parties to purchase equipment or other goods that is secured only by the equipment or other goods. 
 “PERMITTED LIENS” means: (i) liens in favor of Secured Party, (ii) liens for taxes not yet due or for taxes being contested in good faith and which do not involve, in the judgment of Secured Party,
any risk of the sale, forfeiture or loss of any of the Collateral, (iii) inchoate material men’s, mechanic’s, repairmen’s and similar liens arising by operation of law in the normal course of business for amounts which are not
delinquent, (iv) Liens existing on the date hereof and set forth in Schedule B, and (v) Liens on Account Collateral to secure the A/R Facility under the terms set forth in Section 1. 
 “PERSON” is any individual, sole proprietorship, partnership, limited liability company, joint venture, company association, trust,
unincorporated organization, association, corporation, institution, public benefit corporation, firm, joint stock company, estate, entity or government agency. 
 “PMSI COLLATERAL” has the meaning given such capitalized term in Section 1. 
 “PMSI
INDEBTEDNESS” has the meaning given such capitalized term in Section 1. 
 “PRIMARY OPERATING ACCOUNT” has the meaning
given such capitalized term in Section 2(u). 
 “RECEIVABLES” shall mean in addition to the definition of account as contained
in the Uniform Commercial Code (a) all of the Debtor’s present and future accounts, contract rights, receivables, promissory notes and other instruments, chattel paper (including tangible and electronic chattel paper), tax refunds, general
intangibles (excluding the Intellectual Property) and all rights to receive the payment of money or other consideration under present or future contracts including, without limitation, all of the Debtor’s rights under each Government Contract
and all related Government Accounts now owned or hereafter acquired by the Debtor; (b) all present and future cash of the Debtor; (c) all present and future judgments, orders, awards and decrees in favor of the Debtor and causes of action
in favor of the Debtor; (d) all present and future contingent and noncontingent rights of the Debtor to the payment of money for any reason whatsoever, whether arising in contract, tort or otherwise including, without limitation, all rights to
receive payments under presently existing or hereafter acquired or created letters of credit; (e) all present and future claims, rights of indemnification and other rights of the Debtor under or in connection with any contracts or agreements to
which the Debtor is or becomes a party or third party beneficiary; (f) all goods previously or hereafter returned, repossessed or stopped in transit, the sale, lease or other disposition of which contributed to the creation of any account,
instrument or chattel paper of the Debtor; (g) all present and future rights of the Debtor as an unpaid seller of goods, including rights of stoppage in transit, detinue and reclamation; (h) all rights which the Debtor may now or at any
time hereafter have, by law or agreement, against any Account Debtor or other obligor of the Debtor, and all rights, liens and security interests which the Debtor may now or at any time hereafter have, by law or agreement, against any property of
any Account Debtor or other obligor of the Debtor; (i) all invoices and shipping documents; and (j) all present and future interests and rights of the Debtor, including rights to the payment of money, under or in connection with all
present and future leases and subleases of real or personal property to which the Debtor is a party, as lessor, sublessor, lessee or sublessee. 
 “SECURED PARTY’S EXPENSES” means all reasonable costs or expenses (including reasonable attorneys’ fees and expenses) incurred in connection with the preparation, negotiation, documentation, administration and funding of
the Debt Documents; and Secured Party’s reasonable attorneys’ fees, costs and expenses incurred in amending, modifying, enforcing or defending the Debt Documents (including fees and expenses of appeal or review), including the exercise of
any rights or remedies afforded hereunder or under applicable law, whether or not suit is brought, whether before or after bankruptcy or insolvency, including without limitation all fees and costs incurred by Secured Party in connection with Secured
Party’s enforcement of its rights in a bankruptcy or insolvency proceeding filed by or against Debtor or its property. 
  

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 “SUBORDINATED INDEBTEDNESS” means Additional Indebtedness subordinated to the Indebtedness of
Debtor to Secured Party on terms and conditions acceptable to Secured Party in its sole discretion. 
 “SUBSEQUENT FINANCING” has
the meaning given such capitalized term in Section 2(v). 
 “THIRD PARTY INSTITUTION” has the meaning given such capitalized
term in Section 3(v). 
 IN WITNESS WHEREOF, Debtor and Secured Party, intending to be legally bound hereby, have duly executed this
Agreement in one or more counterparts, each of which shall be deemed to be an original, as of the day and year first aforesaid. 
  

									
	 SECURED PARTY:
  
 OXFORD FINANCE CORPORATION
	 		 	 DEBTOR:
  
 ALSIUS CORPORATION

					
	By:	 	/s/ Michael J. Allenburger	 		 	By:	 	/s/ William Worthen
	Name:	 	Michael J. Allenburger	 		 	Name:	 	William Worthen
	Title:	 	Chief Financial Officer	 		 	Title:	 	President & CEO

  

 Page 15 

 [Logo] 
 May 31, 2005 
 Mr. William Worthen 
 President and Chief Executive Officer 
 Alsius Corporation 
 15770 Laguna Canyon Road 
 Suite 150 
 Irvine, California 92618 
 Dear Mr. Worthen: 
 This letter sets forth additional terms related to that certain credit arrangement whereby Oxford Finance Corporation (the “Lender”) has agreed
to loan Five Million Dollars ($5,000,000.00) to Alsius Corporation (the “Borrower”) pursuant to the terms contained in the Debt Documents [as such term is defined in that certain Master Security Agreement (the “Loan Agreement”),
between Lender and Borrower, dated May 31, 2005], and has agreed to negotiate lending an additional amount (the “Additional Advance”) to the Borrower as provided in that certain term sheet dated as of March 25, 2005 received by
the Borrower from the Lender. The Borrower shall have the option to the Additional Advance during 2006 in an amount equal to the principal paid down at that time on the original $5,000,000.00. The Additional Advance will be on the same terms as in
the Loan Agreement for the original $5,000,000.00 amount, including the collateral, interest rate, term, covenants and additional warrants (which will be calculated based on 7% of the Additional Advance and which will cover the most recent preferred
stock then issued by the Borrower). However, in no event will the Lender be obligated to allow the Borrower to draw down the Additional Advance, and such Additional Advance shall be subject to approval by Lender’s Credit Committee at such time.

 [remainder of the page intentionally left blank] 
 [signatures only appear on next page] 
 OXFORD FINANCE CORPORATION 
 133 North Fairfax Street 
 Alexandria, Virginia 22314 
 Tel: 703-519-4900 Fax: 703-519-4910 
 WWW.OXFORDFINANCE.COM 

	
	Sincerely,
	
	/s/ Michael J. Altenburger
	Chief Financial Officer
	
	OXFORD FINANCE CORPORATION
	Michael J. Altenburger
	Chief Financial Officer

  

			
	 ACKNOWLEDGED AND AGREED:
  
 Alsius Corporation

	
	/s/ William Worthen
		
	By:	 	William Worthen
	Its:	 	President & CEO

 PROMISSORY NOTE 
 TO MASTER SECURITY AGREEMENT NO. 5051091 
 May 31, 2005 
 (DATE) 
 FOR VALUE RECEIVED, Alsius Corporation, a California
corporation, located at the address stated below (“MAKER”) promises, jointly and severally if more than one, to pay to the order of OXFORD FINANCE CORPORATION or any subsequent holder hereof (each, a “PAYEE”) at its office
located at 133 N. FAIRFAX STREET, ALEXANDRIA, VA 22314 or at such other place as Payee or the holder hereof may designate, the principal sum of FIVE MILLION DOLLARS ($5,000,000.00), with interest on the unpaid principal balance, from the date hereof
through and including the dates of payment, at a fixed interest rate of ten and sixty-five one-hundredths percent (10.65%) per annum. Beginning on July 1, 2005, and continuing on the first day of August and September, 2005 (each, a
“Payment Date”), Maker shall make three (3) consecutive monthly payments of interest only as follows: 
  

				
	 Periodic Installment
	  	Amount
	 1-3
	  	$	44,375.00 each

 Thereafter, commencing on October 1, 2005, and continuing on the first day of each succeeding month
thereafter (each, a “Payment Date”), maker shall make payments of principal and interest in thirty-six (36) consecutive monthly installments of principal and interest as follows: 
  

				
	 Periodic Installment
	  	Amount
	 4-39
	  	$	162,866.09 each

 (each payment of interest only and principal and interest being a “PERIODIC INSTALLMENT”), with the
final installment which shall be in the amount of the total outstanding principal and interest, if any. Such installments have been calculated on the basis of a 360-day year of twelve 30-day months. Each payment may, at the option of the Payee, be
calculated and applied on an assumption that such payment would be made on its due date. Maker agrees to pay any initial partial month interest payment from the date of this Note to the first day of the following month (“Interim
Interest”). 
 The acceptance by Payee of any payment which is less than payment in full of all amounts due and owing at such time shall not constitute
a waiver of Payee’s right to receive payment in full at such time or at any prior or subsequent time. 
 The Maker hereby expressly authorizes the Payee
to insert the date value is actually given in the blank space on the face hereof and on all related documents pertaining hereto. 
 This Note may be secured
by a security agreement, chattel mortgage, pledge agreement or like instrument (each of which is hereinafter called a “SECURITY AGREEMENT” AND ANY SECURITY AGREEMENT, THIS NOTE AND ANY OTHER DOCUMENT EVIDENCING OR SECURING THIS LOAN IS
HEREINAFTER CALLED A “DEBT DOCUMENT”). 
 Time is of the essence hereof. If any installment or any other sum due under this Note or any Security
Agreement is not received when due, the Maker agrees to pay, in addition to the amount of each such installment or other sum, a late payment charge of five percent (5%) of the amount of said installment or other sum, but not exceeding any
lawful maximum. If (i) Maker fails to make payment of any amount due hereunder; or (ii) Maker is in default under, or fails to perform under any term or condition contained in any Security Agreement, then the entire principal sum remaining
unpaid, together with all accrued interest thereon and any other sum payable under this Note or any Security Agreement, at the election of Payee, shall immediately become due and payable, with interest thereon at the lesser of eighteen percent
(18%) per annum or the highest rate not prohibited by applicable law from the date of such accelerated maturity until paid (both before and after any judgment). 
 Notwithstanding anything to the contrary contained herein or in the Security Agreement, Maker may prepay in full, but not in part, and only after the first annual anniversary date of this Note, its entire Indebtedness
hereunder, as of the date of prepayment, by payment of the entire Indebtedness plus an additional sum as a premium equal to the following percentages of the remaining principal balance for the indicated period: 
 IMPORTANT NOTICE: 
 THIS INSTRUMENT CONTAINS
A CONFESSION OF JUDGMENT PROVISION WHICH CONSTITUTES A WAIVER OF IMPORTANT RIGHTS YOU MAY HAVE AS A DEBTOR AND ALLOWS THE CREDITOR TO OBTAIN A JUDGMENT AGAINST YOU WITHOUT ANY FURTHER NOTICE. 
  

 Page 1 

 After the first annual anniversary date of this Note, and prior to the second annual anniversary date of
this Note: Four percent (4%) 
 After the second annual anniversary date of this Note, and prior to the third annual anniversary date of this
Note: Three percent (3%) 
 The Maker and all sureties, endorsers, guarantors or any others (each such person, other than the Maker, an “OBLIGOR”)
who may at any time become liable for the payment hereof jointly and severally consent hereby to any and all extensions of time, renewals, waivers or modifications of, and all substitutions or releases of, security or of any party primarily or
secondarily liable on this Note or any Security Agreement or any term and provision of either, which may be made, granted or consented to by Payee, and agree that suit may be brought and maintained against any one or more of them, at the election of
Payee without joinder of any other as a party thereto, and that Payee shall not be required first to foreclose, proceed against, or exhaust any security hereof in order to enforce payment of this Note. The Maker and each Obligor hereby waives
presentment, demand for payment, notice of nonpayment, protest, notice of protest, notice of dishonor, and all other notices in connection herewith, as well as filing of suit (if permitted by law) and diligence in collecting this Note or enforcing
any of the security hereof, and agrees to pay (if and to the extent permitted by law) all expenses incurred in collection, including Payee’s actual attorneys’ fees. Maker and each Obligor agrees that fees not in excess of ten percent
(10%) of the amount then due shall be deemed reasonable. 
 Maker and Payee intend to strictly comply with all applicable federal and Virginia laws,
including applicable usury laws (or the usury laws of any jurisdiction whose usury laws are deemed to apply to the Note or any other Debt Document despite the intention and desire of the parties to apply the usury laws of the Commonwealth of
Virginia). Accordingly, the provisions of this paragraph shall govern and control over every other provision of this Note or any other Debt Document which conflicts or is inconsistent with this Section, even if such provision declares that it
controls. As used in this paragraph, the term “INTEREST” includes the aggregate of all charges, fees, benefits or other compensation which constitute interest under applicable law, provided that, to the maximum extent permitted by
applicable law, (a) any non-principal payment shall be characterized as an expense or as compensation for something other than the use, forbearance or detention of money and not as interest, and (b) all interest at any time contracted for,
reserved, charged or received shall be amortized, prorated, allocated and spread, in equal parts during the full term of the obligations. In no event shall Maker or any other person be obligated to pay, or Payee have any right or privilege to
reserve, receive or retain, (a) any interest in excess of the maximum amount of non-usurious interest permitted under the laws of the Commonwealth of Virginia or the applicable laws (if any) of the United States or of any other state, or
(b) total interest in excess of the amount which Payee could lawfully have contracted for, reserved, received, retained or charged had the interest been calculated for the full term of the obligations. On each day, if any, that the interest
rate (the “Stated Rate”) called for under this Note or any other Debt Document exceeds the maximum non-usurious rate, the rate at which interest shall accrue shall automatically be fixed by operation of this sentence at the maximum
non-usurious rate for that day. Thereafter, interest shall accrue at the Stated Rate unless and until the Stated Rate again exceeds the maximum non-usurious rate, in which case, the provisions of the immediately preceding sentence shall again
automatically operate to limit the interest accrual rate to the maximum non-usurious rate. The daily interest rates to be used in calculating interest at the maximum non-usurious rate shall be determined by dividing the applicable maximum
non-usurious rate by the number of days in the calendar year for which such calculation is being made. None of the terms and provisions contained in this Note or in any other Debt Document which directly or indirectly relate to interest shall ever
be construed without reference to this paragraph, or be construed to create a contract to pay for the use, forbearance or detention of money at an interest rate in excess of the maximum non-usurious rate. If the term of any obligation is shortened
by reason of acceleration of maturity as a result of any Default or by any other cause, or by reason of any required or permitted prepayment, and if for that (or any other) reason Payee at any time, including but not limited to, the stated maturity,
is owed or receives (and/or has received) interest in excess of interest calculated at the maximum non-usurious rate, then and in any such event all of any such excess interest shall be canceled automatically as of the date of such acceleration,
prepayment or other event which produces the excess, and, if such excess interest has been paid to Payee, it shall be credited pro tanto against the then-outstanding principal balance of Maker’s obligations to Payee, effective as of the date or
dates when the event occurs which causes it to be excess interest, until such excess is exhausted or all of such principal has been fully paid and satisfied, whichever occurs first, and any remaining balance of such excess shall be promptly refunded
to its payor. 
 THE MAKER HEREBY UNCONDITIONALLY WAIVES ITS RIGHTS TO A JURY TRIAL OF ANY CLAIM OR CAUSE OF ACTION BASED UPON OR ARISING OUT OF, DIRECTLY OR
INDIRECTLY, THIS NOTE, ANY OF THE RELATED DOCUMENTS, ANY DEALINGS BETWEEN MAKER AND PAYEE RELATING TO THE SUBJECT MATTER OF THIS TRANSACTION OR ANY RELATED TRANSACTIONS, AND/OR THE RELATIONSHIP THAT IS BEING ESTABLISHED BETWEEN MAKER AND PAYEE. THE
SCOPE OF THIS WAIVER IS INTENDED TO BE ALL ENCOMPASSING OF ANY AND ALL DISPUTES THAT MAY BE FILED IN ANY COURT (INCLUDING, WITHOUT LIMITATION, CONTRACT CLAIMS, TORT CLAIMS, BREACH OF DUTY CLAIMS, AND ALL OTHER COMMON LAW AND STATUTORY CLAIMS.) THIS
WAIVER IS IRREVOCABLE, MEANING THAT IT MAY NOT BE MODIFIED EITHER ORALLY OR IN WRITING, AND THE WAIVER SHALL APPLY TO ANY SUBSEQUENT AMENDMENTS, RENEWALS, SUPPLEMENTS OR MODIFICATIONS TO THIS NOTE, ANY RELATED DOCUMENTS, OR TO ANY OTHER DOCUMENTS OR
AGREEMENTS RELATING TO THIS TRANSACTION OR ANY RELATED TRANSACTION. IN THE EVENT OF LITIGATION, THIS NOTE MAY BE FILED AS A WRITTEN CONSENT TO A TRIAL BY THE COURT. 
 IMPORTANT NOTICE: 
 THIS INSTRUMENT CONTAINS
A CONFESSION OF JUDGMENT PROVISION WHICH CONSTITUTES A WAIVER OF IMPORTANT RIGHTS YOU MAY HAVE AS A DEBTOR AND ALLOWS THE CREDITOR TO OBTAIN A JUDGMENT AGAINST YOU WITHOUT ANY FURTHER NOTICE. 
  

 Page 2 

 This Note and any Security Agreement constitute the entire agreement of the Maker and Payee with respect to the subject
matter hereof and supercedes all prior understandings, agreements and representations, express or implied. 
 No variation or modification of this Note, or
any waiver of any of its provisions or conditions, shall be valid unless in writing and signed by an authorized representative of Maker and Payee. Any such waiver, consent, modification or change shall be effective only in the specific instance and
for the specific purpose given. 
 Any provision in this Note or any Security Agreement which is in conflict with any statute, law or applicable rule shall
be deemed omitted, modified or altered to conform thereto. 
 Upon receipt of an affidavit of an officer of Payee as to the loss, theft, destruction or
mutilation of this Note or any Debt Document which is not of public record, and, in the case of any such loss, theft, destruction or mutilation, upon surrender and cancellation of such Note or other Debt Document, Maker will issue, in lieu thereof,
a replacement Note or other Debt Document in the same principal amount thereof and otherwise of like tenor. 
 It is understood and agreed that this Note and
all of the Debt Documents were negotiated and have been or will be delivered to Payee in the Commonwealth of Virginia, which State the parties agree has a substantial relationship to the parties and to the underlying transactions embodied by this
Note and the Debt Documents. Maker agrees to furnish to Payee at Payee’s office in Alexandria, VA, all further instruments, certifications and documents to be furnished hereunder. The parties also agree that if collateral is pledged to secure
the debt evidenced by this Note, that the state or states in which such collateral is located each have a substantial relationship to the parties and to the underlying transaction embodied by this Note and the Debt Documents. 
 MAKER AGREES THAT THE PAYEE OF THIS NOTE SHALL HAVE THE OPTION BY WHICH STATE LAWS THIS NOTE SHALL BE GOVERNED AND CONSTRUED: (A) THE LAWS OF THE COMMONWEALTH OF
VIRGINIA; OR (B) IF COLLATERAL HAS BEEN PLEDGED TO SECURE THE DEBT EVIDENCED BY THIS NOTE, THEN BY THE LAWS OF THE STATE OR STATES WHERE THE COLLATERAL IS LOCATED, AT PAYEE’S OPTION. THIS CHOICE OF STATE LAWS IS EXCLUSIVE TO THE PAYEE OF
THIS NOTE. MAKER SHALL NOT HAVE ANY OPTION TO CHOOSE THE LAWS BY WHICH THIS NOTE SHALL BE GOVERNED. MAKER AND GUARANTORS HEREBY CONSENT TO THE EXERCISE OF JURISDICTION OVER IT BY ANY FEDERAL COURT SITTING IN VIRGINIA OR ANY VIRGINIA COURT SELECTED
BY PAYEE, FOR THE PURPOSES OF ANY AND ALL LEGAL PROCEEDINGS ARISING OUT OF OR RELATING TO THE NOTE, THE LOAN AGREEMENT AND ALL OTHER DOCUMENTS. MAKER AND GUARANTORS IRREVOCABLY WAIVE, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY OBJECTION WHICH IT
MAY NOW OR HEREAFTER HAVE TO THE LAYING OF VENUE OF ANY SUCH PROCEEDING BROUGHT IN ANY SUCH COURT, ANY CLAIM BASED ON THE CONSOLIDATION OF PROCEEDINGS IN SUCH COURTS IN WHICH PROPER VENUE MAY LIE IN DIVERGENT JURISDICTIONS, AND ANY CLAIM THAT ANY
SUCH PROCEEDING BROUGHT IN ANY SUCH COURT HAS BEEN BROUGHT IN AN INCONVENIENT FORUM. MAKER AND GUARANTORS HEREBY IRREVOCABLY WAIVE, TO THE FULLEST EXTENT PERMITTED BY LAW, ANY AND ALL RIGHT TO TRIAL BY JURY IN ANY LEGAL PROCEEDING ARISING OUT OF OR
RELATING TO THIS NOTE, THE OTHER DOCUMENTS OR THE TRANSACTIONS CONTEMPLATED THEREBY. 
 Confession of Judgment. In the event that this Note or any
installment under this Note is not paid when due, whether by maturity or acceleration, Maker hereby appoints and constitutes Mary Zinsner and David J. Lawson, either of whom may act (a Virginia attorney) Maker’s duly constituted
attorney-in-fact to confess judgment pursuant to the provisions of Section 8.01-431 et seq. of the Code of Virginia of 1950, as amended, against Maker for all principal and interest due and payable under this Note, together with attorneys’
fees and collection fees as provided in this Note (to the extent permitted by law), which judgment shall be confessed in the Clerk’s Office of the Circuit Court of the City of Alexandria and/or Fairfax and/or Arlington Counties, Virginia. Maker
shall, upon Payee’s request, name such additional or alternative persons designated by Payee as Maker’s duly constituted attorney-in-fact to confess judgment against Maker pursuant to the above Section. Upon request of Payee, Maker also
shall agree to the designation of any additional circuit courts in the Commonwealth of Virginia in which judgment may be confessed against Maker. No single exercise of the power to confess judgment shall be deemed to exhaust the power and no
judgment against fewer than all the persons constituting Maker shall bar any subsequent action or judgment against any one or more of such persons against whom judgment has not been obtained on this Note. 
 IMPORTANT NOTICE: 
 THIS INSTRUMENT CONTAINS
A CONFESSION OF JUDGMENT PROVISION WHICH CONSTITUTES A WAIVER OF IMPORTANT RIGHTS YOU MAY HAVE AS A DEBTOR AND ALLOWS THE CREDITOR TO OBTAIN A JUDGMENT AGAINST YOU WITHOUT ANY FURTHER NOTICE. 
  

 Page 3 

									
		 		 	ALSIUS CORPORATION
				
	/s/ Dawn Steele	 		 	By:	 	/s/ William Worthen
	(Witness)	 		 		 	
	Dawn Steele	 		 	Name:	 	William Worthen
	(Print name)	 		 		 	
	 650 Town Center Drive, 7th Floor
 Costa Mesa, CA 92626
	 		 	Title:	 	President & CEO
	(Address)	 		 		 	

  

									
		 		 	Federal Tax ID #:33-0493151
				
		 		 	Address:	 	 15770 Laguna Canyon Road,
 Suite 150 Irvine,

California 92618

 IMPORTANT NOTICE: 
 THIS INSTRUMENT CONTAINS A CONFESSION OF JUDGMENT PROVISION WHICH CONSTITUTES A WAIVER OF IMPORTANT RIGHTS YOU MAY HAVE AS A DEBTOR AND ALLOWS THE CREDITOR TO OBTAIN A JUDGMENT AGAINST YOU WITHOUT ANY FURTHER NOTICE.

  

 Page 4Asset Purchase Agreement with Tiber, Inc. dated October 4, 2006

 Exhibit 10.1 
 ASSET PURCHASE AGREEMENT 
 This Asset Purchase Agreement (this “Agreement”) is made
and entered into as of October 4, 2006, by and among TEAMM Pharmaceuticals, Inc., a Florida corporation (“Seller”), Accentia BioPharmaceuticals, Inc., a Florida corporation, (“Parent”) and Tiber, Inc., a Georgia
corporation (the “Buyer”). 
 RECITALS 
 WHEREAS, subject to the terms and conditions of this Agreement, Seller desires to sell to Buyer, and Buyer desires to purchase from Seller, the Purchased Assets (as defined below). 
 AGREEMENT 
 NOW, THEREFORE, in
consideration of the premises and the mutual covenants and promises contained herein, and for other good and valuable consideration, the receipt and sufficiency of which hereby are acknowledged, the Parties agree as follows: 
 Article I. Definitions 
 Construction of Certain Terms and Phrases. 
  

	1.0	Unless the context of this Agreement otherwise requires: (a) words of any gender include each other gender; (b) words using the singular or plural number also include the
plural or singular number, respectively; (c) the terms “hereof,” “herein,” “hereby” and derivative or similar words refer to this entire Agreement; (d) the terms “Article,” “Section” or
“Exhibit” refer to the specified Article, Section or Exhibit of this Agreement; (e) the term “or” has, except where otherwise indicated, the inclusive meaning represented by the phrase, “and/or”; and (f) the
term “including” means “including without limitation.” Whenever this Agreement refers to a number of days, such number shall refer to calendar days unless Business Days are specified. All accounting terms used but not otherwise
defined herein shall have the meanings ascribed to such terms under U.S. Generally Accepted Accounting Principles. The Agreement was negotiated by the Parties with the benefit of legal representation, and any rule of construction or interpretation
otherwise requiring this Agreement to be construed against any Party shall not apply to any construction or interpretation hereof. 

 As used in this Agreement, the following defined terms have the meanings described below: 
  

	1.1	“Action or Proceeding” means any action, suit, proceeding, arbitration, Order, inquiry, hearing, assessment with respect to fines or penalties or litigation
(whether civil, criminal, administrative, investigative or informal) commenced, brought, conducted or heard by or before, or otherwise involving, any Governmental or Regulatory Authority. 

	1.2	“Adverse Effect” means an effect or condition that individually or in the aggregate is materially adverse to the Purchased Assets or the business, results of
operations, or financial condition of the Business. 

  

	1.3	“Affiliate” means, with respect to any Person, any other Person which controls, is controlled by or is under common control with such person or entity. A Person
shall be regarded as in control of another Person if it owns or controls, directly or indirectly, (i) in the case of corporate entities at least fifty percent (50%) (or the maximum ownership interest permitted by law) of the equity
securities in the subject entity entitled to vote in the election of directors and, (ii) in the case of an entity that is not a corporation, at least fifty percent (50%) (or the maximum ownership interest permitted by law) of the equity
securities or other ownership interests with the power to direct the management and policies of such subject entity or entitled to elect the corresponding management authority. 

  

	1.4	“Agreement” has the meaning set forth in the Preamble hereto. 

  

	1.5	“Assets and Properties” of any Person means all assets and properties of any kind, nature, character and description (whether real, personal or mixed, whether
tangible or intangible, whether absolute, accrued, contingent, fixed or otherwise and wherever situated), including the goodwill related thereto, operated, owned or leased by such Person, including cash, cash equivalents, accounts and notes
receivable, chattel paper, documents, instruments, general intangibles, regulatory approvals, equipment, inventory, goods, minute books, stock records and corporate seals, shares of capital stock held in treasury, all personnel records, all claims
for refund of taxes, and all rights in connection with and assets of any employee benefit plans. 

  

	1.6	“Assumed Contract” means those Contracts identified in Article 6.6 of the Seller Disclosure Schedule. 

  

	1.7	“Assumed Liabilities” means (i) all rebates and chargebacks and obligations under or pursuant to the Assumed Contracts received after the Closing Date, so long
as such rebates and chargebacks do not exceed a total of $15,000 for all liabilities for the first quarter beginning October 1, 2006 and ending Dec 31,2006. For purposes of this agreement, rebates and chargebacks for the quarter October 1, 2006
through December 31, 2006 will be assumed to have been from sales incurred prior to the closing date, any rebates received after December 31, 2006 will assumed to be entirely from sales incurred after the Closing Date and will be the sole
obligation of the Buyer. (ii) effective as of the start of the first calendar quarter beginning October 1, 2006, and continuing each quarter thereafter, all state and federal Medicaid/Medicare rebates related to the Products and Product
Inventory that are received after Closing Date, (iii) that portion of returns associated only with the specific lot numbers and percentages identified in Schedule A. 

  

	1.8	“Authority” means any governmental, regulatory or administrative body, agency or authority, any court or judicial authority, any arbitrator or any public, private
or industry regulatory authority, whether foreign, federal, state or local. 

  

 -2- 

	1.9	“Books and Records” means all files, documents, instruments, papers, books and records (other than Marketing Materials) owned by Seller or an Affiliate of Seller
relating exclusively to the Business, including any pricing lists, customer lists, vendor lists and financial data, but excluding any such items to the extent that (i) any applicable Law prohibits their transfer or (ii) any transfer
thereof would subject Seller or any of its Affiliates to any contractual or other Liability or obligation. 

  

	1.10	“Breach” means any breach of, or any inaccuracy in, any representation or warranty or any breach of, or failure to perform or comply with, any covenant or
obligation, in or of this Agreement, or any event which with the passing of time or the giving of notice, or both, would constitute such a breach, inaccuracy or failure. 

  

	1.11	“Business” means the activities of manufacturing, marketing, selling and distributing the Products in the Territory. 

  

	1.12	“Business Day” means a day other than Saturday, Sunday or any day on which banks located in New York are authorized or obligated to close. 

 

	1.13	“Buyer” has the meaning set forth in the Preamble to this Agreement. 

  

	1.14	“Buyer Disclosure Schedule” has the meaning set forth in Article VII hereof. 

  

	1.15	“Buyer Governmental Consent” has the meaning set forth in Article 7.4. 

  

	1.16	“Buyer Indemnified Parties” shall have the meaning set forth in Article 11.2. 

  

	1.17	“Buyer Labeling” means the printed labels, labeling and packaging materials, including printed carton, container labels and package inserts, used by Buyer and
bearing Buyer’s name for the Products. 

  

	1.18	“Closing” has the meaning set forth in Article 5.1. 

  

	1.19	“Closing Date” means the date that the Closing actually occurs as provided in Article 5.1. 

  

	1.20	“Closing Payments” has the meaning set forth in Article 4.1 

  

	1.21	“Confidential Information” has the meaning set forth in Article 12.1. 

  

	1.22	“Contemplated Transactions” means all of transactions contemplated by this Agreement. 

  

	1.23	“Contract” means any and all commitments, contracts, consensual obligations, purchase orders, leases, promises or undertaking or other agreements, whether written
or oral and whether express or implied. 

  

	1.24	“Corporate Names” has the meaning set forth in Article 8.6 

  

	1.25	“Cost of Goods” means the price charged by the manufacturer to Seller. 

  

 -3- 

	1.26	“Encumbrance” means any mortgage, pledge, assessment, security interest, deed of trust, lease, lien, claim, option, pledge, right of way, easement, encroachment,
levy, charge or other encumbrance of any kind, or any conditional sale or title retention agreement or other agreement to give any of the foregoing in the future. 

  

	1.27	“Excluded Assets” means all Assets and Properties of Seller and its Affiliates except the Purchased Assets. 

  

	1.28	“Excluded Liabilities” means i) any product liability claims arising out of the ownership or sale of the Products by Seller prior to the Closing ii) any Liability
for Taxes arising out of the ownership of the Products by Seller prior to the Closing, as well as taxes for the period pre-Closing on inventory, income of Seller, sales and use and ad valorem tax and tax on the sale of the Purchased Assets iii) all
accounts payable incurred by Seller or an Affiliate of Seller with respect to the Business prior to Closing, (iv) any rebate liability for the quarter ending September 30, 2006 as long as Buyer does not adversely affect rebate liability,
(v) any return for Products not specified by lot number in Schedule A and (vi) any other Liability of Seller or any of its Affiliates not expressly assumed by Buyer hereunder. 

  

	1.29	“Food and Drug Laws” means the Federal Food, Drug, and Cosmetic Act of 1938, as amended, and all similar state, local, and foreign laws or ordinances, as well as
all other Federal and state laws related to the development, manufacture, offer for sale, sale, use and import of the Products, including, without limitation, all safety, environmental, and fire and health laws. 

  

	1.30	“GAAP” means generally accepted accounting principles for financial reporting in the United States, applied on a consistent basis on which financial statements are
prepared. 

  

	1.31	“Governmental or Regulatory Authority” means any court, tribunal, arbitrator, authority, agency, commission, official or other instrumentality of the United States
or other country, or any supra-national organization, state, county, city or other political subdivision thereof. 

  

	1.32	“Gross Revenue” means the invoiced amount for Products shipped 

  

	1.33	“Indemnification Claim Notice” has the meaning set forth in Article 11.2(c). 

  

	1.34	“Indemnified Party” has the meaning set forth in Article 11.2(c). 

  

	1.35	“Indemnifying Party” has the meaning set forth in Article 11.2(c). 

  

	1.36	“Indemnitee” and “Indemnitees” have the respective meanings set forth in Article 11.2(c). 

  

	1.37	“Initial Amount” has the meaning set forth in Article 4.2(c). 

  

	1.38	 “Know-how” means all information owned or licensed by Seller and its Affiliates and used exclusively in connection with the Business, including any
Product specifications, technical knowledge, expertise, skill, practice, procedures, formulae, trade secrets, 

  

 -4- 

	 	 
confidential information, analytical methodology, processes, preclinical, clinical, stability and other data, market studies and all other experience and
know-how, in each case in tangible form, whether or not patented or patentable. 

  

	1.39	“Knowledge” with respect to any Party, means the actual knowledge of the senior executive officers of such Party after due inquiry. 

  

	1.40	“Law” means any federal, state or local law, statute or ordinance, or any rule, regulation, or published guidelines promulgated by any Governmental or Regulatory
Authority. 

  

	1.41	“Liability” means any liability (whether known or unknown, asserted or unasserted, absolute or contingent, accrued or unaccrued, liquidated or unliquidated, and due
or to become due), including any liability for Taxes. 

  

	1.42	“Marketing Materials” means all market research, marketing plans, media plans, advertising, promotional and marketing books and records owned by Seller and its
Affiliates and used exclusively in connection with the marketing and promotion of the Products, other than any such items to the extent that (i) any applicable Law prohibits their transfer or (ii) any transfer thereof would subject Seller
or any of its Affiliates to any contractual or other Liability or obligation. 

  

	1.43	“Net Revenue” means the Gross Revenues of the Products less credits for rebates, shipping costs, chargebacks, Product returns and other discounts deducted from the
payment made by the customer. 

  

	1.44	“Non-disclosing Party” has the meaning set forth in Article 12.1. 

  

	1.45	“Order” means any order, writ, judgment, decree, ruling, injunction, assessment or arbitration award or similar order of any Governmental or Regulatory Authority
(in each such case whether preliminary or final) or arbitrator. 

  

	1.46	“Ordinary Course of Business” means such action that is consistent in nature, scope and magnitude with the past practices of the Business. 

 

	1.47	“Parties” means Buyer and Seller. 

  

	1.48	“Party” means each of Buyer and Seller. 

  

	1.49	“Permits” means all qualifications, registrations, filings, privileges, franchises, immunities, licenses, permits, authorizations and approvals of Authorities which
are used or required in the development, manufacture, offer for sale, sale, use and import of the Products, including, without limitation, all certificates, licenses and permits relating to building, safety, environmental laws, Food and Drug Laws,
fire and health. 

  

	1.50	“Permitted Encumbrance” means any minor imperfection of title or similar Encumbrance that individually or in the aggregate would not have an Adverse Effect to
Buyer. 

  

 -5- 

	1.51	“Person” means any natural person, corporation, general partnership, limited partnership, limited liability company, proprietorship, other business organization,
business trust, trust, union, unincorporated association or Governmental or Regulatory Authority. 

  

	1.52	“Products” means HistexTM HC, HistexTM SR, HistexTM Liquid,
HistexTM PD, HistexTM CT, HistexTM and all reformulations or line extensions under the
Histex trade name manufactured to date or hereafter, excluding HistexTM PD-12 and HistexTM IE, and includes the Trademarks, Products in the Distribution Channel, tooling and equipment, licenses and permits, Marketing Materials and packaging
supplies. 

  

	1.53	“Products in the Distribution Channel” means all products physically held in any entity that distributes or dispenses such products including, but not limited to,
wholesalers, distributors, chain warehouses, retail drugstores, clinics, hospitals, buying groups or mail order distributors. 

  

	1.54	“Product Inventory” means all inventory as set forth on Seller’s Disclosure Schedule Article 6.7 (which shall be updated as of Closing), including all
inventory of finished Product in all sizes and presentation including all reformulations owned as of the Closing by Seller or any Affiliate thereof of finished Product or works in progress or materials used in the manufacture of finished Product
including all reformulations held at a location or facility of Seller, any Affiliate of Seller or any of Seller’s contract manufacturers. Article 6.7 of the Seller Disclosure Schedule lists the Product Inventory of finished Products acquired by
Buyer as of the Closing. 

  

	1.55	“Pull-Through” means for the specific time period, the sum of (i) the dispensing of the Product Inventory and the Products in the Distribution Channel for the
NDC codes listed on Exhibit C as evidenced by Wolters Kluwer reporting data and (ii) the Returns Report minus the Shipment Report. The amount of Pull-Through shall be subject to audit by Seller in accordance with the provisions set
forth in Article 4.2(ii). 

  

	1.56	“Purchase Price” has the meaning set forth in Article IV. 

  

	1.57	“Purchased Assets” means (i) the Products; (ii) the Product Inventory; (iii) Products in the Distribution Channel, (iv) Sample Inventory
(v) the Assumed Contracts; (vi) the Trademarks; and (vii) the Marketing Materials. 

  

	1.58	“Regulatory Approvals” means, as they relate exclusively to the Products and to the extent owned or licensed by Seller, the new drug applications and new drug
submissions for the Products, all supplements thereto and all regulatory files relating thereto and all other regulatory approvals and governmental registrations made by or issued to Seller that relate specifically to pertaining to the Products,
Transferred Patents, or Permits. 

  

	1.59	“Royalty End Date” means the date three (3) years following the Closing Date. 

  

 -6- 

	1.60	“Returns Report” means a report totaling all credit memoranda issued and/or payments made by Buyer to customers with respect to Products in the Distribution Channel
and Product Inventory that were returned to Buyer. Each Returns Report shall contain, at a minimum, the specific Product(s) and Product Inventory and number of bottles of such Product(s) and Product Inventory returned to Buyer, the customer(s) and
the dollar amount of payments made or credits issued to such customer(s). The first Returns Report will be for the period from the Closing Date through the end of the month immediately following Closing. Thereafter the Returns Report will be for
monthly time periods. Returns Reports will be transmitted no later than ten (10) days following the close of the month. 

  

	1.61	“Sales Discounts and Allowances” means any sales discounts and/or other allowances, including but not limited to, promotions and terms given to such customers in
the normal course of Business. 

  

	1.62	“Seller” has the meaning set forth in the Preamble to this Agreement. 

  

	1.63	“Seller Disclosure Schedule” has the meaning set forth in the preamble to Article VI of this Agreement. 

  

	1.64	“Shipment Report” means a report totaling all shipments of Product Inventory made by Buyer to customers. Each Shipment Report shall contain, at a minimum, the
specific Product Inventory and number of bottles of the Product Inventory shipped by Buyer, the customer(s) and the dollar amount of shipments made to such customer(s). The first Shipment Report will be for the period from the Closing Date through
December 31, 2006 . Thereafter, the Shipment Report will be for quarterly time periods. 

  

	1.65	“Specified Know-How” means all proprietary inventions, technology, trade secrets, know-how, data, procedures and other information, in each case that (a) have
been reduced to writing or stored electronically or are in another tangible form, and (b) relate exclusively to the Products. 

  

	1.66	“Tax” means all of the following tax in connection with the operations of the Business or the Contemplated Transactions: (i) any net income, alternative or
add-on minimum tax, gross income, gross receipts, sales, use, ad valorem, transfer, franchise, profits, license, excise, severance, stamp, occupation, premium, property, environmental or windfall profit tax, custom, duty or other tax, governmental
fee or other like assessment imposed by an Governmental or Regulatory Authority responsible for the imposition of any such tax (domestic or foreign) or payable under any tax-sharing agreement or any other contract; (ii) any Liability for the
payment of any amounts of the type described in (i) as a result of being a member of any affiliated, consolidated, combined, unitary or other group for any taxable period; and (iii) any Liability for the payment of any amounts of the type
described in (i) or (ii) as a result of any express or implied obligation to indemnify any other person. 

  

 -7- 

	1.66	“Territory” means the United States of America. 

  

	1.67	“Trademarks” means the trade name, trade dress, logos, common law trademarks or service marks and registered trademarks or service marks and the associated goodwill
with respect to the Products. 

 Article II. Purchase and Sale of Assets 
  

	2.1	Subject to the terms and conditions of this Agreement, at the Closing, Seller shall sell, transfer, convey, assign and deliver to Buyer, and Buyer shall purchase, acquire and accept
from Seller, all of Seller’s and each such Affiliate’s right, title and interest, as of the Closing, in and to the Purchased Assets free and clear of Encumbrances, with the exception for Permitted Encumbrances. The Excluded Assets are not
part of the sale and purchase of the Contemplated Transactions, are excluded from the Purchased Assets and shall remain the property of Seller after Closing. 

  

	2.2	Notwithstanding anything contained in this Agreement to the contrary, Seller may retain an archival copy of all Assumed Contracts, Books and Records, Marketing Materials and other
documents or materials conveyed hereunder. 

 Article III. Assumption of Assumed Liabilities 
  

	3.1	Subject to the terms and conditions of this Agreement, as of the Closing Date, Buyer agrees to assume, satisfy, perform, pay, discharge and otherwise be responsible for the Assumed
Liabilities. The Excluded Liabilities shall remain the sole responsibility of and shall be retained, paid, performed and discharged solely by Seller. 

 Article IV. Purchase Price and Payment 
  

	4.1	Purchase Price. As consideration for the Purchased Assets, Buyer shall: 

 (a) (i) pay a cash purchase price for the Products and Marketing Materials equal to $150,000 payable at Closing; and (ii) pay a cash purchase price of $61,143 for the Product Inventory equal to the Cost of
Goods as estimated by Seller for the inventory as listed on Exhibit A payable at closing. Buyer shall confirm the inventory within four (4) months of closing, with an adjustment to the Purchase Price made at the time of the first royalty
payment. 
  

 -8- 

 (b) Assume the Assumed Liabilities. 
 (c) The Closing payments shall be paid by Buyer to Seller in cash by wire transfer of immediately available funds to an account or
accounts designated by Seller prior to the Closing Date. 
  

	4.2	Additional Consideration. As additional consideration for the Purchased Assets: 

 (a) Additional Payments. Buyer shall pay from the Closing Date and for a period of three (3) years to Seller a quarterly
royalty payment equal to eight percent (8%) of Net Revenue for the commercial sale of each Product. The minimum royalty due to Seller is $166,667 for each rolling12 month period quarter paid as provided in paragraph (b) below. The payment
each quarter shall be the higher of the minimum payment for the quarter, ($41,500) or 8% of Net Revenue, adjusted as provided herein. However, if the sales in any rolling 12 month period are less than $2,075,000.00, the royalty payment due for such
period will not exceed $166,667.00. 
 (b) Each payment to be made pursuant to this Article 4.2 shall be paid to Seller no
later than the forty-fifth (45th) day after the end of each calendar quarter by check not less than two (2) Business Days prior to the date on which such payment is due. 
 (c) In the event the Buyer shall sublicense or re-license the Products to a third party, Seller shall continue to receive a quarterly
royalty payment equal to eight percent (8%) on the commercial net sales of each Product and Product Inventory until the Royalty End Date subject to the payment provisions described in this Article 4.2 and subject to the minimum royalty
described in this Article 4.2. 
 (d) In the event of rebates, returns, Sales Discounts and Allowances or other adjustments to
Net Revenue occurring after the Royalty End Date, Buyer shall bill Seller for such adjustment with payment due thirty (30) days thereafter and an eight percent (8%) per annum interest charge shall be added to all delinquent payments.
However for purposes of this agreement, minimum royalties must be met for the time period as listed in 4.2(a) and would not be lowered for returns, rebates, Sales Discounts and Allowances or other adjustments with the sole exception in response to
FDA action listed in 4.2(e). 
 (e) Anything herein to the contrary notwithstanding, in the event that the FDA or other
Authority takes action to remove the Products from the market or prevents their sale, then all royalty payments shall cease immediately. In the event, however, that products under the Histex trade name return for commercial sale within the royalty
period outlined in this agreement, then royalty payments would resume for the remaining period. 
 (f) Buyer shall be
responsible and shall hold seller harmless for all Assumed Liabilities as listed in Article 1.7. Seller shall prepare a report for Buyer listing in detail any payments that may be due to Seller to reimburse Seller for any Assumed Liabilities. The
reports shall be submitted to the Buyer within ten (10) days of the close of the quarter and the amount due shall be paid with, and in addition to, the Buyer’s royalty payment. 
  

 -9- 

 (g) Within thirty days following proof to Buyer that Seller has paid return liability in
excess of $100,000 over a two (2) year period from the Closing Date on Histex Products that is not an Assumed Liability, excluding returns from Histex IE and Histex PD 12, Buyer will reimburse Seller $25,000. 
 (i) Reports; Payments. In connection with each quarterly royalty payment set forth in Article 4.2(a) hereof, Buyer shall provide an
estimated report by the tenth (10th) day after each quarterly period and a final report when the quarterly
royalty payment is due setting forth the calculation of Net Revenue for each Product and Product Inventory for the applicable period and the amount of the royalty payment due, each in sufficient detail to permit Seller to determine whether the
calculation of Net Revenue and the calculation of the royalty payment due is fair estimate. Buyer shall cause its representatives and employees to be reasonably available to Seller to discuss any questions or comments of Seller concerning such
report. 
 (ii) Records; Access; Audit for Net Revenue. Buyer shall use commercially reasonable efforts to keep
complete and accurate records of sales and all other information necessary to accurately calculate the Net Revenue for the periods described above and keep such records through the Royalty End Date and for an additional twelve (12) months.
Until the Royalty End Date and for a period of twelve (12) additional months, Seller shall have the right through its representatives or an independent, certified public accountant to audit such records at the place or places of business where
such records are customarily kept in order to verify the accuracy of the reports of Net Revenue made hereunder. Such audits may be exercised during normal business hours upon ten (10) days prior written notice to Buyer, provided that notice is
given at least sixty (60) days after the due date of such royalty payment. Seller shall bear the full cost of such audit unless such audit discloses a variance of more than ten percent (10%) from the amount of any payment calculated with
respect to Net Revenue under this Agreement, in which case Buyer shall bear the full cost of such audit. In the event that Buyer disputes the results of Seller’s audit, Buyer may through its representative or an independent certified public
accountant, agreeable to the Seller, audit such records and if Buyer disputes the claimed amount of shortfall, Buyer shall provide notice of such dispute in writing with reasonable detail to Seller and Buyer and Seller shall attempt to resolve such
dispute in good faith. If within twenty (20) days after receipt of the dispute by Seller, the Parties have been unable to resolve the dispute amicably, the matter will be resolved by an independent accounting firm of nationally recognized
standing (the “Arbitrator”) that is mutually agreed upon by both Buyer and seller for final resolution. Should the Parties be unable to agree on an Arbitrator, one will be appointed by the American Arbitration Association. Any amounts that
are determined to be due and owing by Buyer to Seller or by Seller to Buyer following such audit, including the fees and expenses of the Arbitrator, if necessary, shall be paid within ten (10) days thereafter, together with any interest due
thereon (at a rate equal to nine percent (9%) per annum) for any amounts owing by one Party to the other. 
  

 -10- 

 (iii) Records; Access; Audit for Product Inventory and Products in the Distribution
Channel. For a period of two years following the Closing Date, Buyer shall keep complete and accurate records of any returns and Sales Discounts and Allowances. Seller shall have the right through its representatives or an independent, certified
public accountant to audit such records pertaining to the Purchased Assets, including the Returns Report and Shipment Report, at the place or places of business where such records are customarily kept in order to verify the accuracy of the returns
and the Returns Report and Shipment Reports made hereunder. Such audits may be exercised during normal business hours upon ten (10) days prior written notice to Buyer. 
 (b) Responsibility for Product Inventory and Products in the Distribution Channel. Seller shall be responsible for payment of
returns on all Product Inventory and Products in the Distribution Channel; Buyer will then reimburse Seller for that portion of returns as specified in Schedule A. Seller shall remain liable for all manufacturing defects, product liability, and any
other liability related to such Product Inventory and Product placed in the distribution channel prior to the Closing Date, and the Product Inventory listed on Exhibit A. 
  

	4.3	Payment of Sales, Use and Other Taxes. Seller shall be solely responsible for all sales, use, transfer and other related Taxes, if any, arising out of the sale by Seller and its
Affiliates of the Purchased Assets to Buyer pursuant to this Agreement. Buyer and Seller hereby waive compliance with the bulk transfer provisions of the uniform commercial code (or any similar law) (“Bulk Sales Laws”) in connection with
this Agreement. 

 Article V. Closing 
  

	5.1	Time and Place. The closing of the transactions contemplated by this Agreement, including without limitation the purchase and sale of the Purchased Assets and the assumption of the
Assumed Liabilities (the “Closing”) shall take place as promptly as practicable, but no later than October 10, 2006 at the offices of Seller, unless another time or place shall be agreed to by the Parties.

  

	5.2	Deliveries at Closing. 

 (a) Closing
Deliveries by Seller. At the Closing, Seller shall deliver or cause to be delivered to Buyer: 
 (i) Trademark assignments
necessary to transfer the Trademarks to Buyer in form and substance reasonably acceptable to Seller and Buyer; 
 (ii) A bill
of sale in form and substance reasonably acceptable to Seller and Buyer to transfer the Products, Product Inventory, Sample Inventory, Books and Records and Marketing Materials to Buyer; 
  

 -11- 

 (iii) Within five (5) days of closing, to transfer all warehoused inventory of
Products to the location designated by Buyer by Buyer’s designated transport carrier and at Buyer’s expense 
 (b)
Closing Deliveries by Buyer. At the Closing, Buyer shall deliver or cause to be delivered to Seller: 
 (i) the Closing
payments in cash or by wire transfer in accordance with Article 4.1 hereof; 
 (ii) assignment and assumption agreements,
reasonably satisfactory to Seller and Buyer, assigning to Buyer all rights and obligations of Seller in and to the Assumed Contracts; 
 (iii) such instruments of assumption and other instruments or documents, in form and substance reasonable acceptable to Seller and Buyer, as may be necessary to effect Buyer’s assumption of the Assumed
Liabilities; 
 (iv) the certificates and other documents to be delivered pursuant to Article X hereof. 
  

	5.3	At and after Closing, Seller and Buyer shall cooperate and make commercially reasonable efforts to arrange the transfer of rights with respect to all Assumed Contracts with third
parties relating to the Products from Seller to Buyer. 

 Article VI. Representations and Warranties of Seller

  

	6.1	Seller and Parent represent and warrant to Buyer as of the date hereof, subject to such exceptions as are specifically disclosed in the disclosure schedule (referencing the
appropriate Sections hereof) supplied by Seller to Buyer and dated as of the date hereof (the “Seller Disclosure Schedule”), which Seller Disclosure Schedule shall be deemed to be representations and warranties of Seller as if made
herein, as follows: 

  

	6.2	Seller is a corporation duly organized, validly existing and in good standing under the laws of the State of Florida and has all requisite power and authority to own its assets and
carry on the Business as currently conducted by it. 

  

	6.3	 Seller has all necessary power and authority and has taken all actions necessary to enter into this Agreement and to carry out the Contemplated Transactions. The
Board of Directors of Seller has taken all action required by Law or its organizational documents to be taken by it to authorize the execution and delivery of this Agreement by the Seller and the consummation of the Contemplated Transaction. This
Agreement has been duly 

  

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and validly executed and delivered by Seller and, when executed and delivered by Buyer, will constitute a legal, valid and binding obligation of Seller
enforceable against it in accordance with its terms except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement of creditors rights generally, and
(b) as limited by laws relating to the availability of specific performance, injunctive relief or other equitable remedies. 

  

	6.4	Non-Contravention. The execution and delivery by Seller of this Agreement does not, and the performance by it of its obligations under this Agreement and the consummation of the
Contemplated Transactions will not: 

 (a) conflict with or result in a violation or Breach of any of the terms,
conditions or provisions of the Certificate of Incorporation, as amended, and Bylaws of Seller; 
 (b) conflict with or result
in a violation or Breach of any term or provision of any Law applicable to Seller, the Business or the Purchased Assets, other than such conflicts, violations or Breaches as would not have an Adverse Effect; or 
 (c) conflict with or result in a Breach or default (or an event which, with notice or lapse of time or both, would constitute a Breach or
default) under, or result in the termination or cancellation of, or accelerate the performance required by, or result in the creation or imposition of any security interest, lien or any other Encumbrance (other than a Permitted Encumbrance), other
than such conflicts, Breaches or defaults as would not have an Adverse Effect. 
  

	6.5	Trademarks. Article 6.5 of the Seller Disclosure Schedule sets forth a complete and correct list of Trademarks. To the knowledge of the Seller, the Trademarks are not involved in
any opposition, invalidation or cancellation proceeding. 

  

	6.6	Assumed Contracts. Article 6.6 of the Seller Disclosure Schedule sets forth a list of Contracts to which Seller is a party that relates to the marketing, sale or distribution of the
Products and that relates to the purchase or disposition of assets, or the provision of services. Seller has made available to Buyer copies of the Assumed Contracts identified in Article 6.6 of the Seller Disclosure Schedule. Seller will make
reasonable efforts to assist Buyer in their efforts to assume contracts. Regarding each the Assumed Contracts, Seller warrants and represents (a) that there have been no previous defaults, (b) that there have been no notices of default,
and (c) that Seller has no knowledge of any default. 

  

	6.7	Inventory. Article 6.7 of the Seller Disclosure Schedule sets forth a list of all Product Inventory and Sample Inventory of finished Product by lot number acquired by Buyer.

  

	6.8	 Litigation. To the knowledge of the Seller there are no Actions or Proceedings currently pending or, to the Knowledge of Seller, threatened or reasonably
anticipated against, relating to, affecting or arising, except for such Actions or Proceedings that could not reasonably be expected to have an Adverse Effect, in connection with (a) the Purchased Assets or the Business; (b) this
Agreement; or (c) the Contemplated Transactions. Seller 

  

 -13- 

	 	 
is not subject to any Order that could reasonably be expected to materially impair or delay the ability of Seller to perform its obligations hereunder.

  

	6.9	Brokers. Seller has not retained any broker in connection with the Contemplated Transactions. Buyer has no, and will have no, obligation to pay any brokers, finders, investment
bankers, financial advisors or similar fees in connection with the Contemplated Transactions by reason of any action taken by or on behalf of Seller. 

  

	6.10	Consents. All consents, waivers, approvals, Orders, authorizations of, declarations or filings with any Governmental or Regulatory Authority (each a “Seller Governmental
Consent”) that are required by or with respect to the Seller in connection with the execution and delivery of this Agreement by Seller, have been obtained prior to Closing, except to the extent that the failure to obtain such Seller
Governmental Consent would not have an Adverse Effect. 

  

	6.11	Compliance with Laws. To the knowledge of Seller with respect to the Purchased Assets, Seller is in compliance with all applicable rules, regulations, and statutes including but not
limited to those administered, issued or promulgated by the FDA as well as any governing body that govern the sale of pharmaceuticals, except where failure to so comply could not reasonably be expected to result in an Adverse Effect.

  

	6.12	Insurance. Seller has maintained product liability insurance covering the Purchased Assets, which policy is valid, outstanding and enforceable; is issued by an insurer that is
financially sound and reputable provides a minimum of $5 million insurance coverage with respect to the Purchased Assets; and no notice of cancellation or non-renewal has been received by Seller. 

  

	6.13	Title to Assets. Except for Products in the Distribution Channel, Seller is the sole owner and has good title to all of the Purchased Assets, free and clear of Encumbrances, with
the exception for Permitted Encumbrances. 

  

	6.14	No Returns Held. Seller has not instructed, knowingly or otherwise, any accounts to hold returns of Products. 

  

	6.15	Excluded Liabilities. Seller shall pay when due all Excluded Liabilities 

  

	6.16	Regulatory Matters

 (a) Seller is in
compliance with the laws applicable to the development, manufacture, labeling, testing and inspection of the Products, and with all applicable regulations, policies and procedures promulgated by the FDA with respect thereto. Seller has received no
written notice that any recalls, field notifications or seizures have been ordered or, to Seller’s knowledge, threatened by any governmental body with respect to any of the Products with the acknowledged exception of the recent FDA guidance
document related to products containing carbinoxamine. Seller has not received a warning letter or other similar written notice from the FDA regarding the Products 
  

 -14- 

 (b) None of the Products has been denied, placed on hold, withdrawn, suspended or
discontinued as a result of any action by the FDA or any other similar Authority, by Seller or by any licensee or customer of any Product, in the United States or outside the United States (whether voluntarily or otherwise). No proceedings in the
United States or outside of the United States (whether completed or pending) seeking the withdrawal, suspension or seizure of any Product or Permit related thereto are pending against Seller, any Product, or any licensee or customer of any Product,
nor have any such proceedings been pending at any prior time. 
 (c) To the knowledge of the Seller, no officer, employee or
agent of Seller, has made an untrue statement of a material fact or fraudulent statement to the FDA or any other Authority, failed to disclose a material fact required to be disclosed to the FDA or any other authority, or committed an act, made a
statement, or failed to make a statement that, at the time such disclosure was made, could reasonably be expected to provide a basis for the FDA or any other Authority to invoke with respect to Seller its policy respecting “Fraud, Untrue
Statements of Material Facts, Bribery, and Illegal Gratuities”, set forth in 56 Fed. Reg. 46191 (September 10, 1991) or any similar policy, and (ii) nor has, to the knowledge of Seller, any officer, employee or agent of Seller, has been
convicted of any crime or engaged in any conduct for which debarment is mandated by 21 U.S.C. Section 335a(a) or any similar legal provision or permitted by 21 U.S.C. Section335a(b) or any similar legal provision. 
 (d) Seller has not received any written notice that the FDA or any other Authority has commenced, or overtly threatened to initiate, any
action to enjoin production of any of the Products. 
  

	6.17	No Adverse Effect. No event creating an Adverse Effect affecting the Purchased Assets or the Products has occurred as of the Closing Date. 

 Article VII. Representations and Warranties of Buyer 
  

	7.1	Buyer represents and warrants to Seller as of the date hereof, subject to such exceptions as are specifically disclosed in the disclosure schedule (referencing the appropriate
Sections hereof) supplied by Buyer to Seller and dated as of the date hereof (the “Buyer Disclosure Schedule”), which Buyer Disclosure Schedule shall be deemed to be representations and warranties of Buyer as if made herein, as
follows: 

  

 -15- 

	7.2	Corporate Organization. Buyer is a corporation duly organized, validly existing and in good standing under the laws of the State of Georgia and has all requisite power and authority
to own its assets and carry on its business as currently conducted by it. Buyer is duly authorized to conduct its business and is in good standing in each jurisdiction where such qualification is required, except for any jurisdiction where failure
to so qualify could not reasonably be expected, individually or in the aggregate, to have a Adverse effect on Buyer or materially impair or delay Buyer’s ability to perform its obligations hereunder. 

  

	7.3	Authority of Buyer. Buyer has all necessary power and authority and has taken all actions necessary to enter into this Agreement and to carry out the Contemplated Transactions. The
Board of Directors of Buyer has taken all action required by Law, its Certificate of Incorporation, Bylaws or otherwise to be taken by it to authorize the execution and delivery of this Agreement by Buyer and the consummation of the Contemplated
Transactions. This Agreement has been duly and validly executed and delivered by Buyer and, when executed and delivered by Seller, will constitute a legal, valid and binding obligation of Buyer enforceable against it in accordance with its terms
except (a) as limited by applicable bankruptcy, insolvency, reorganization, moratorium and other laws of general application affecting enforcement of creditors rights generally, and (b) as limited by laws relating to the availability of
specific performance, injunctive relief or other equitable remedies. 

  

	7.4	Consents and Approvals. All consents, waivers, approvals, Orders, authorizations of, declarations or filings with any Governmental or Regulatory Authority (each a “Buyer
Governmental Consent”) that are required by or with respect to Buyer in connection with the execution and delivery of this Agreement by Buyer have been obtained prior to Closing, except to the extent that the failure to obtain such Buyer
Governmental Consent would not have an Adverse Effect. 

  

	7.5	Non-Contravention. The execution and delivery by Buyer of this Agreement does not, and the performance by it of its obligations under the Contemplated Transactions will not:

 (a) conflict with or result in a violation or Breach of any of the terms, conditions or provisions of the
Certificate of Incorporation, Bylaws or other organizational documents of Buyer; 
 (b) conflict with or result in a violation
or Breach of any term or provisions of any Law applicable to Buyer other than such conflicts, violations or Breaches as would not have an Adverse Effect; or 
 (c) conflict with or result in a Breach or default (or an event which, with notice or lapse of time or both, would constitute a Breach or
default) under, or result in the termination or cancellation of, or accelerate the performance required by, or result in the creation or imposition of any security interest, lien or any other Encumbrance (other than a Permitted Encumbrance) upon any
Contract to which Buyer is a party or by which Buyer or any of its assets is bound, other than such conflicts, Breaches or defaults as would not have an Adverse Effect. 
  

 -16- 

	7.6	Litigation. There are no Actions or Proceedings pending, or to the Knowledge of Buyer threatened or anticipated, against, relating to, affecting or arising in connection with
(a) this Agreement or (b) the Contemplated Transactions. Buyer is not subject to any Order that could reasonably be expected to materially impair or delay the ability of Buyer to perform its obligations hereunder. 

 

	7.7	Brokers. Buyer has not retained any broker in connection with the Contemplated Transactions. Seller has no, and will have no, obligation to pay any brokers, finders, investment
bankers, financial advisors or similar fees in connection with this Agreement or the Contemplated Transactions by reason of any action taken by or on behalf of Buyer. 

 Article VIII. Covenants of the Parties 
  

	8.1	Maintenance of Business Prior to Closing. Seller has not accelerated the volume of sales of the Products and Product Inventory, not announced Product price increases and not sold or
disposed of Product Inventory other than Histex PD-12 and Histex IE and sales of Products and Product Inventory in the Ordinary Course of Business. 

  

	8.2	Cooperation. Each Party shall cooperate fully with the other in preparing and filing all notices, applications, submissions, reports and other instruments and documents that are
necessary, proper or advisable under applicable Laws to consummate and make effective the Contemplated Transactions, including Seller’s cooperation in the efforts of Buyer to obtain (i) any consents and approvals of any Governmental or
Regulatory Authority required for Buyer to be able to own the Purchased Assets 

  

	8.3	Access. 

 (a) Upon the request of Seller,
Buyer shall at all times following the Closing, to the extent permitted by Law, grant to Seller and its representatives the right, and agreed upon times during normal business hours to inspect and copy the Books and Records and other documents in
Buyer’s possession to the extent pertaining to the operation of the Business prior to the Closing Date for Tax purposes and in connection with Actions or Proceedings. 
 (b) Buyer agrees to keep and maintain all Books and Records and other documents in existence on the Closing Date and make personnel of
Buyer or its Affiliates available to Seller or its representatives to the extent such access is otherwise necessary for Seller to comply with or enforce the terms of this Agreement or comply with any applicable Law or for Tax purposes; it being
understood that Seller shall reimburse Buyer promptly for its reasonable and necessary out of pocket expenses incurred in complying with any such request by or on behalf of Seller. To the extent any Books and Records of Seller remain in its
possession post-Closing, Buyer shall have the right upon reasonable notice and during normal business hours to inspect and copy such Books and Records. 

  

 -17- 

	 	 
This provision shall remain in effect for a period of two (2) years from either the expiry of the royalty payment date or termination of the contract.

  

	8.4	Press Release and Public Announcements. No Party shall issue any press release or make any public announcement relating to the Contemplated Transactions without the prior written
approval of the other Party; provided, however, that any Party may make any public disclosure it believes in good faith is required by applicable law or any listing or trading agreement concerning its publicly-traded securities (in which case the
disclosing Party will use its best efforts to advise the other Party and its counsel at least one day prior to making the disclosure). 

  

	8.5	Non-Solicitation. For a period of three (3) years from the Closing Date, Buyer agrees that Buyer shall not solicit employment from any current employee of Seller or an
Affiliate of Seller or any ex-employee of Seller or an Affiliate of Seller who was employed by Seller or any Affiliate of Seller on October 4, 2006, without the written consent of Seller. 

  

	8.6	Corporate Names. 

 (a) Except as set forth
in this Article 8.6, following the Closing Date, Buyer shall not have any rights by virtue of the Contemplated Transactions to any Trademarks relating to Seller or any of the Affiliates of Seller or any of their products other than the Trademarks.

 (b) Buyer may use Marketing Materials that were transferred to Buyer as Purchased Assets that bear any of the Corporate
Names in connection with its operation of the Business following the Closing and for up to one hundred eighty (180) days thereafter; and thereafter Buyer may use such Marketing Materials only if Buyer completely removes all Corporate Names
from, or completely covers all Corporate Names on, such materials. Buyer acknowledges and agrees that Seller shall have no Liability or other obligation arising out of or in connection with Buyer’s or it Affiliate’s use of the Marketing
Materials. 
 (c) Buyer may use in connection with its operation of the Business until inventory is depleted or goes out of
date , (or such shorter period as any Governmental or Regulatory Authority shall designate) items of Product Inventory and Sample Inventory that bear any Corporate Names, it being understood that Buyer will use its best efforts to use or sell such
items of Product Inventory and Sample Inventory prior to selling or using any other product under the trademark or trade name of the Product Inventory or Sample Inventory, respectively 
  

 -18- 

	8.7	Handling of Product Inventory and Products. From and after the Closing, Buyer shall hold, store, and ship any Product Inventory and returned Products in the Distribution Channel
substantially in accordance with (a) all applicable Laws, (b) current good manufacturing practices, (c) the applicable Regulatory Approvals, and (d) applicable analytical methods and procedures, material specifications, master
batch records, and stability protocols 

  

	8.8	Labeling Requirements. Following the Closing, Buyer shall, at its own expense and as expeditiously as possible, use all reasonable efforts to obtain such FDA approvals necessary for
Buyer Labeling for the Products to be manufactured after the Closing and, promptly comply with such FDA approvals upon receipt thereof. 

  

	8.9	Further Assurances. 

 (a) On and after the
Closing, Seller shall from time to time, at the request of Buyer, execute and deliver, or cause to be executed and delivered, such other instruments of conveyance and transfer and take such other actions as Buyer may reasonably request, in order to
more effectively consummate the Contemplated Transactions and to vest in Buyer good and marketable title to the Purchased Assets. 
 (b) On and after the Closing, Buyer shall from time to time, at the request of Seller, take such actions as Seller may reasonably request, in order to more effectively consummate the Contemplated Transactions, including Buyer’s
assumption of the Assumed Liabilities. 
  

	8.10	Handling of Products and Product Inventory Returned to Seller. If any of the Products or Product Inventory are returned to Seller, Seller shall invoice Buyer for any costs not to
exceed actual costs incurred by Seller with respect such returns and shall i) for Products or Product Inventory with “6 months or more dating,” and in case quantities return same to Buyer, or ii) for Products or Product Inventory with
“6 months or less dating,” deliver same to a destruction facility contractor of Buyer’s choice and at Buyer’s expense. 

  

	8.11	No Competing Products. Both Buyer and Seller acknowledge that both parties currently market products in the same therapeutic area for the same indication. Seller and each of its
Affiliates shall not develop, manufacture or distribute any products other than those Seller already markets or distributes for the same indication that has a, trade name confusingly similar to the Products sold to Buyer hereunder for a period of
five (5) years after the Closing. 

  

 19 

 Article IX. Conditions to the Obligations of Seller 
 The obligation of Seller to effect the Contemplated Transactions is subject to the satisfaction (or waiver by Seller), at or before the Closing, of each
of the following conditions: 
  

	9.1	Representations, Warranties and Covenants. All representations and warranties of Buyer contained in this Agreement shall be true and correct in all material respects on and as of
the Closing Date as though given on and as of such date and Buyer shall have performed all agreements and covenants required by this Agreement to be performed by it prior to or on the Closing Date, and Seller shall have received a certificate to
such effect dated the Closing Date and executed by a duly authorized officer of Buyer. 

  

	9.2	No Actions or Proceedings. No Actions or Proceedings that question the validity or legality of the Contemplated Transactions shall have been instituted or threatened and not settled
or otherwise terminated. 

 Article X. Conditions to the Obligations of Buyer 
 The obligation of Buyer to effect the Contemplated Transactions is subject to the satisfaction (or waiver by Buyer), at or before the Closing, of each of
the following conditions: 
  

	10.1	Representations, Warranties and Covenants. All representations and warranties of Parent and Seller contained in this Agreement shall be true and correct in all material respects on
and as of the Closing Date as though given on and as of such date, excluding for such purpose any representations and warranties that are by their terms given only as of a specific date, and Seller shall have performed all agreements and covenants
required by this Agreement to be performed by it prior to or on the Closing Date, and Buyer shall have received a certificate to such effect dated the Closing Date and executed by a duly authorized officer of Seller. 

  

	10.2	No Actions or Proceedings. No Actions or Proceedings that question the validity or legality of the Contemplated Transactions shall have been instituted or threatened and not settled
or otherwise terminated. 

  

	10.3	Other Closing Deliveries. Seller shall have delivered to Buyer such other certificates and documents customary in transactions similar to those contemplated hereby that are
reasonably requested by Buyer. 

  

	10.4	Adverse Effect. No event creating an Adverse Effect affecting the Purchased Assets shall have occurred from the date of this Agreement through Closing such that Buyer reasonably
determines that the Contemplated Transactions are no longer beneficial to its interests. 

  

 -20- 

 Article XI. Indemnification 
  

	11.1	Survival of Representations, Warranties, Etc. The representations, warranties and covenants of Seller and Buyer contained in this Agreement shall survive the Closing.

  

	11.2	Indemnification. 

 (a) By Seller.
Subject to Articles11.3 and 11.4, from and after the Closing, Seller and Parent shall indemnify, reimburse, defend and hold harmless Buyer, its Affiliates, and their respective officers, directors, employees, agents, successors and assigns
(collectively, the “Buyer Indemnified Parties”) from and against any and all costs, losses, Liabilities, damages, lawsuits, deficiencies, claims and expenses (including interest, penalties and reasonable fees and disbursements of
attorneys paid in connection with the investigation, defense or settlement of any of the foregoing) (collectively, the “Damages”), to the extent resulting from (i) any inaccuracy or Breach of any covenant, representation,
warranty or other agreement of Parent or Seller herein, or (ii) the failure of Seller to pay, perform or discharge any Excluded Liabilities. 
 (b) By Buyer. Subject to Articles11.3 and 11.4, from and after the Closing, Buyer shall indemnify, reimburse, defend and hold harmless Seller, its Affiliates and their respective officers, directors, employees,
agents, successors and assigns from and against any and all Damages resulting from (i) any inaccuracy or Breach of any covenant, representation, warranty or other agreement of Buyer herein, (ii) Buyer’s conduct of the Business from
and after the Closing; and (iii) the failure of Buyer to pay, perform or discharge any Assumed Liabilities. 
 (c)
Procedures. The indemnified Party (the “Indemnified Party”) shall give the indemnifying Party (the “Indemnifying Party”) prompt written notice (an “Indemnification Claim Notice”) of any
Damages or discovery of fact upon which such Indemnified Party intends to base a request for indemnification under Article 11.2(a) or Article 11.2(b), but in no event shall the Indemnifying Party be liable for any Damages that result from any delay
in providing such notice. Each Indemnification Claim Notice must contain a reasonable description of the claim and the nature and amount of such Damages (to the extent that the nature and amount of such Damages are known at such time). The
Indemnified Party shall furnish promptly to the Indemnifying Party copies of all papers and official documents received in respect of any Damages. All indemnification claims in respect of a Party, its Affiliates or their respective directors,
officers, employees and agents (collectively, the “Indemnitees” and each an “Indemnitee”) shall be made solely by such Party to this Agreement. 
  

 -21- 

 (d) Third Party Claims. The obligations of an Indemnifying Party under this
Article 11.2 with respect to Damages arising from claims of any third party that are subject to indemnification as provided for in Article 11.2(a) or Article 11.2(b) (a “Third Party Claim”) shall be governed by and be contingent
upon the following additional terms and conditions: 
 (i) At its option, the Indemnifying Party may assume the defense of any
Third Party Claim by giving written notice to the Indemnified Party within thirty (30) days after the Indemnifying Party’s receipt of an Indemnification Claim Notice. The assumption of the defense of a Third Party Claim by the Indemnifying
Party shall not be construed as an acknowledgment that the Indemnifying Party is liable to indemnify any Indemnitee in respect of the Third Party Claim, nor shall it constitute a waiver by the Indemnifying Party of any defenses it may assert against
any Indemnitee’s claim for indemnification. Upon assuming the defense of a Third Party Claim, the Indemnifying Party may appoint as lead counsel in the defense of the Third Party Claim any legal counsel selected by the Indemnifying Party that
is reasonably acceptable to the Indemnified Party. In the event the Indemnifying Party assumes the defense of a Third Party Claim, the Indemnified Party shall promptly deliver to the Indemnifying Party all original notices and documents (including
court papers) received by any Indemnitee in connection with the Third Party Claim. Should the Indemnifying Party assume the defense of a Third Party Claim, except as provided in subsection (ii) below, the Indemnifying Party shall not be liable
to the Indemnified Party or any other Indemnitee for any legal expenses subsequently incurred by such Indemnified Party or other Indemnitee in connection with the analysis, defense or settlement of the Third Party Claim. In the event that it is
ultimately determined that the Indemnifying Party is not obligated to indemnify, defend or hold harmless an Indemnitee from and against the Third Party Claim, the Indemnified Party shall reimburse the Indemnifying Party for any and all costs and
expenses (including attorneys’ fees and costs of suit) and any Damages incurred by the Indemnifying Party in its defense of the Third Party Claim with respect to such Indemnitee. 
 (ii) Without limiting Article 11.2(d)(i), any Indemnitee shall be entitled to participate in, but not control, the defense of such Third
Party Claim and to employ counsel of its choice for such purpose; provided, however, that such employment shall be at the Indemnitee’s own expense unless (A) the employment thereof has been specifically authorized in advance by the
Indemnifying Party in writing, (B) the Indemnifying Party has failed to assume the defense and employ counsel in accordance with Article 11.2(d)(i) (in which case the Indemnified Party shall control the defense) or (C) if the Indemnified
Party and the Indemnifying Party are both named parties to the proceeding and the Indemnified Party has reasonably concluded that there may be one or more legal defenses that are different from or in addition to those available to the Indemnifying
Party (in which case the Indemnifying Party shall not have the right to assume the defense of such action on behalf of the Indemnified Party and the Indemnifying Party shall be liable for all legal expenses incurred by the Indemnified Party in
furtherance thereof). 
 (iii) With respect to any Damages relating solely to the payment of money damages in connection with
a Third Party Claim and that will not result in the Indemnitee’s becoming subject to injunctive or other relief or otherwise materially adversely affect the business of the Indemnitee in any manner, and as to which the Indemnifying Party shall
have acknowledged in writing the obligation to indemnify the Indemnitee hereunder, the Indemnifying Party shall have the sole right to consent to the entry of any judgment, enter into any settlement or otherwise dispose of such Damages, 

  

 -22- 

 
on such terms as the Indemnifying Party, in its sole discretion, shall deem appropriate. With respect to all other Damages in connection with Third Party
Claims, where the Indemnifying Party has assumed the defense of the Third Party Claim in accordance with Article 11.2(d)(i), the Indemnifying Party shall have authority to consent to the entry of any judgment, enter into any settlement or otherwise
dispose of such Damages; provided that it obtains the prior written consent of the Indemnified Party (which consent shall not be unreasonably withheld or delayed). The Indemnifying Party shall not be liable for any settlement or other disposition of
Damages by an Indemnitee that is reached without the written consent of the Indemnifying Party (which consent shall not be unreasonably withheld or delayed). Regardless of whether the Indemnifying Party chooses to defend or prosecute any Third Party
Claim, no Indemnitee shall admit any liability with respect to, or settle, compromise or discharge, any Third Party Claim without the prior written consent of the Indemnifying Party. 
 (iv) Regardless of whether the Indemnifying Party chooses to defend or prosecute any Third Party Claim, the Indemnified Party shall, and
shall cause each other Indemnitee to, cooperate in the defense or prosecution thereof and shall furnish such records, information and testimony, provide such witnesses and attend such conferences, discovery proceedings, hearings, trials and appeals
as may be reasonably requested in connection therewith. Such cooperation shall include access during normal business hours afforded to the Indemnifying Party to, and reasonable retention by the Indemnified Party of, records and information that are
reasonably relevant to such Third Party Claim, and making Indemnitees and other employees and agents available on a mutually convenient basis to provide additional information and explanation of any material provided hereunder, and the Indemnifying
Party shall reimburse the Indemnified Party for all its reasonable out-of-pocket expenses in connection therewith. 
 (e)
Expenses. Except as provided above, the costs and expenses, including fees and disbursements of counsel, incurred by the Indemnified Party in connection with any claim shall be reimbursed on a quarterly basis by the Indemnifying Party,
without prejudice to the Indemnifying Party’s right to contest the Indemnified Party’s right to indemnification and subject to refund in the event the Indemnifying Party is ultimately held not to be obligated to indemnity the Indemnified
Party. 
  

	11.3	Limitations 

 (a)The amount of any Damages
under Article 11.2(a) and 11.2(d) shall be reduced by the amount of any insurance proceeds paid to the Indemnified Party relating to such claim. 
 (b)The right of the Buyer Indemnified Parties to indemnification under this Article XI shall be the exclusive remedy of the Buyer Indemnified Parties with respect to claims incurred in connection with, arising out of,
resulting from or incident to (i) any 

  

 -23- 

 
inaccuracy or Breach of any covenant, representation, warranty or other agreement of Seller herein, or (ii) the failure of Seller to pay, perform or
discharge any Excluded Liabilities. 
  

	11.4	Limitation of Liability. EXCEPT AS PROVIDED FOR IN SECTIONS 11.01, 11.02 AND 11.03, NEITHER SELLER NOR BUYER SHALL BE LIABLE TO THE OTHER OR ANY THIRD PARTY BY REASON OF ANY
REPRESENTATION OR WARRANTY, CONDITION OR OTHER TERM OR ANY DUTY OF COMMON LAW, OR UNDER THE EXPRESS TERMS OF THIS AGREEMENT, FOR ANY CONSEQUENTIAL, SPECIAL OR INCIDENTAL OR PUNITIVE LOSS OR DAMAGE (WHETHER FOR LOSS OF CURRENT OR FUTURE PROFITS, LOSS
OF ENTERPRISE VALUE OR OTHERWISE) AND WHETHER OCCASIONED BY THE NEGLIGENCE OF SELLER OR ANY OF THEIR RESPECTIVE OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR REPRESENTATIVES. 

 Article XII. Miscellaneous 
  

	12.1	Confidentiality. 

 (a) In addition to the
restrictions contained in Article 8.4, after the Closing, no Party (a “Disclosing Party”) shall, without the prior written consent of the other Party (the “Non-disclosing Party”), disclose to any Person Confidential
Information (as defined below) of the Non-disclosing Party, except to a Disclosing Party’s or its Affiliates employees or representatives who need to know such information for any reason contemplated by the Contemplated Transactions (and then
only to the extent that such persons are under an obligation to maintain the confidentiality of the Confidential Information), or use any Confidential Information of the Non-disclosing Party for any reason other than the Contemplated Transactions
unless such Disclosing Party has (i) consulted with the Non-disclosing Party and obtained the Non-disclosing Party’s prior written consent, and (ii) been advised by counsel that disclosure is required to be made under applicable Law
or the requirements of a national securities exchange or another similar regulatory body. In the event that the Disclosing Party is requested or required by documents subpoena, civil investigative demand, interrogatories, requests for information,
or other similar process to disclose any Confidential Information, the Disclosing Party shall provide the Non-disclosing Party with prompt written notice of such request or demands or other similar process so that the Non-disclosing Party may seek
an appropriate protective order or, if such request, demand or other similar process is mandatory, waive the Disclosing Party’s compliance with the provisions of this Section 12.01(a) as appropriate. 
 (b) The term “Confidential Information” as used in this Section 12.01 means (i) as to Buyer, all confidential
information relating to Buyer’s business, the 

  

 -24- 

 
Purchased Assets and the Assumed Liabilities, and (ii) as to Seller, all confidential information relating to the Business (other than the Purchased
Assets and the Assumed Liabilities) and the business and operations of the Seller and its Affiliates, including the Excluded Assets or other obligations other than the Assumed Liabilities, in each of (i) and (ii) whether disclosed prior to
or after the date hereof. The term “Confidential Information” does not include information which becomes generally available to the public other than as a result of disclosure by the Disclosing Party, or becomes available to the Disclosing
Party on a non-confidential basis from a source other than the Non-disclosing Party, provided that such source is not bound by a confidentiality agreement with the Non-disclosing Party. 
  

	12.2	Notices. All notices, requests and other communications hereunder must be in writing and will be deemed to have been duly given only if delivered personally against written receipt
or by facsimile transmission with answer back confirmation or mailed (postage prepaid by certified or registered mail, return receipt requested) or by nationally recognized overnight courier that maintains records of delivery to the Parties at the
following addresses or facsimile numbers: 

  

			
	If to Seller to:	  	TEAMM Pharmaceuticals, Inc.
		  	2501 Aerial Center Parkway
		  	Suite 100
		  	Morrisville, NC 27560
		  	Attention: Martin Baum, President_
		  	Facsimile: 919-481-9311
		
	With copies to:	  	
		
		  	ACCENTIA BIOPHARMACEUTICALS, INC.
		  	324 South Hyde Park Ave., Suite 350
		  	Tampa, Florida 33606
		  	Attention: Corporate Counsel
		  	Facsimile: (813) 258-6912
		
	If to Buyer to:	  	Tiber Pharmaceuticals, Inc
		  	5400 Laurel Springs Parkway
		  	Building 500
		  	Suwanee, GA 30024
		  	Attention: Rich Gorman
		  	Facsimile: 770-886-3917
		
	With copies to:	  	Rivers Edge Pharmaceuticals , LLC
		  	5400 Laurel Springs Parkway
		  	Building 500
		  	Suwanee, GA 30024
		  	Attention: Brendan Murphy
		  	Facsimile: 770-886-3917

  

 -25- 

 All such notices, requests and other communications will (i) if delivered personally to the address as provided in
this Section, be deemed given upon receipt, (ii) if delivered by facsimile to the facsimile number as provided in this Section, be deemed given upon receipt by the sender of the answer back confirmation and (iii) if delivered by mail in
the manner described above or by overnight courier to the address as provided in this Section, be deemed given upon receipt (in each case regardless of whether such notice, request or other communication is received by any other Person to whom a
copy of such notice, request or other communication is to be delivered pursuant to this Section). Any Party from time to time may change its address, facsimile number or other information for the purpose of notices to that Party by giving notice
specifying such change to the other Parties hereto in accordance with the terms of this Section. 
  

	12.3	Entire Agreement. This Agreement (and all Exhibits and Schedules attached hereto and all other documents delivered in connection herewith) supersedes all prior discussions and
agreements among the Parties with respect to the subject matter hereof and contains the sole and entire agreement among the Parties hereto with respect to the subject matter hereof. 

  

	12.4	Waiver. Any term or condition of this Agreement may be waived at any time by the Party that is entitled to the benefit thereof, but no such waiver shall be effective unless set
forth in a written instrument duly executed by or on behalf of the Party waiving such term or condition. No waiver by any Party hereto of any term or condition of this Agreement, in any one or more instances, shall be deemed to be or construed as a
waiver of the same or any other term or condition of this Agreement on any future occasion. All remedies, either under this Agreement or by law or otherwise afforded, will be cumulative and not alternative. 

  

	12.5	Amendment. This Agreement may be amended, supplemented or modified only by a written instrument duly executed by each Party hereto. 

  

	12.6	Third Party Beneficiaries. The terms and provisions of this Agreement are intended solely for the benefit of each Party hereto and their respective successors or permitted assigns
and it is not the intention of the Parties to confer third-party beneficiary rights upon any other Person. 

  

	12.7	Assignment; Binding Effect. Neither this Agreement nor any right, interest or obligation hereunder may be assigned by any Party hereto without the prior written consent of the other
Party hereto (which consent shall not be unreasonably withheld) and any attempt to do so will be void; provided that Seller shall be entitled to assign any rights to receive payments hereunder without Buyer’s consent. This Agreement is binding
upon, inures to the benefit of and is enforceable by the Parties hereto and their respective successors and permitted assigns. 

  

 -26- 

	12.8	Headings. The headings used in this Agreement have been inserted for convenience of reference only and do not define or limit the provisions hereof 

  

	12.9	Severability. If any provision of this Agreement is held to be illegal, invalid or unenforceable under any present or future law, and if the rights or obligations of any Party
hereto under this Agreement will not be materially and adversely affected thereby, (a) such provision will be fully severable, (b) this Agreement will be construed and enforced as if such illegal, invalid or unenforceable provision had
never compromised a part hereof, (c) the remaining provisions of this Agreement will remain in full force and effect and will not be affected by the illegal, invalid or unenforceable provision or by its severance herefrom, and (d) in lieu
of such illegal, invalid or unenforceable provision, there will be added automatically as a part of this Agreement a legal, valid and enforceable provision as similar to terms to such illegal, invalid or unenforceable provision as may be possible
and reasonably acceptable to the Parties herein. 

  

	12.10	Governing Law. THIS AGREEMENT SHALL BE GOVERNED BY AND CONSTRUED IN ACCORDANCE WITH THE LAWS OF THE STATE OF FLORIDA APPLICABLE TO CONTRACTS EXECUTED AND PERFORMED IN SUCH STATE,
WITHOUT GIVING EFFECT TO CONFLICTS OF LAWS PRINCIPLES. 

  

	12.11	Expenses. Except as otherwise provided in this Agreement, each Party hereto shall pay its own expenses and costs incidental to the preparation of the Contemplated Transactions.

  

	12.12	Counterparts. This Agreement may be executed in any number of counterparts and by facsimile, each of which will be deemed an original, but all of which together will constitute one
and the same instrument. 

  

	12.13	Schedules, Exhibits and Other Agreements. The Exhibits, Schedules, other agreements, certificates and notices specifically referred to herein, and delivered pursuant hereto, are an
integral part of this Agreement. 

  

 -27- 

 IN WITNESS WHEREOF, this Agreement has been executed by the Parties hereto all as of the date first above
written. 
  

					
	TEAMM PHARMACEUTICALS, INC., a Florida Corporation
		
	By:	 	/s/  Martin Baum
		 	 Name:
	 	 Martin Baum

		 	 Title:
	 	 President and Chief Executive Officer

	
	ACCENTIA BIOPHARAMCEUTICALS, INC.
		
	By:	 	/s/  Alan Pearce
		 	 Name:
	 	 Alan Pearce

		 	 Title:
	 	 Chief Financial Officer

	
	TIBER LABORATORIES, a Georgia Corporation
		
	By:	 	/s/  Richard M. Gorman
		 	 Name:
	 	 Richard M. Gorman

		 	 Title:
	 	 President

  

 -28- 

 Article 6.5 Seller Disclosure Schedule 
 To Seller’s Knowledge, Seller may have common law trademark rights with respect to the following products: 
 HistexTM HC 
 HistexTM SR 
 HistexTM Liquid 
 HistexTM PD 
  

 -29- 

 Article 6.6 Seller Disclosure Schedule 
  

																											
	 ACCOUNT NAME
	  	Contract2	  	NDC	  	NDCDesc	  	Tier	  	TierDesc	  	BEGDATE	  	ENDDATE	  	RBAmt	  	ADAmt	  	CODE	  	Type	  	Total
Rebate	  	Active
	Histex CT	  		  		  		  		  		  		  		  		  		  		  		  		  	
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733625801	  	Histex CT	  	1	  		  	04/01/03	  	12/31/06	  	0.1000	  	0.0300	  	PCS	  	PBM	  	0.1300	  	A
														
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733625801	  	Histex CT	  	2	  		  	04/01/03	  	12/31/06	  	0.1100	  	0.0300	  	PCS	  	PBM	  	0.1400	  	A
														
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733625801	  	Histex CT	  	3	  		  	04/01/03	  	12/31/06	  	0.1100	  	0.0300	  	PCS	  	PBM	  	0.1400	  	A
														
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733625801	  	Histex CT	  	4	  		  	04/01/03	  	12/31/06	  	0.1200	  	0.0300	  	PCS	  	PBM	  	0.1500	  	A
														
	 FEDERAL SUPPLY SCHEDULE
	  	090103FSS	  	6733625801	  	Histex CT	  		  		  	09/01/03	  	12/31/99	  	0.2602	  	—  	  	FSS	  	GOV	  	0.2600	  	A
														
	 MCKESSON
	  	031504MCK	  	6733625801	  	Histex CT	  		  		  	03/15/04	  	12/31/99	  	0.2430	  	—  	  	MCK	  	WHLS	  	0.2430	  	A
														
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733625801	  	Histex CT	  	2	  	MailOrder	  	07/01/03	  	06/30/07	  	0.2500	  	—  	  	MMH	  	PBM	  	0.2500	  	A
														
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733625801	  	Histex CT	  	3	  	Medicare	  	03/15/04	  	06/30/06	  	0.2310	  	—  	  	MMH	  	PBM	  	0.2310	  	A
														
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733625801	  	Histex CT	  		  		  	07/01/03	  	06/30/07	  	0.2200	  	0.0300	  	MMH	  	PBM	  	0.2500	  	A
														
	 PUBLIC HEALTH SERVICE
	  	070102PHS	  	6733625801	  	Histex CT	  	14	  		  	04/01/06	  	06/30/06	  	0.3694	  	—  	  	PHS	  	GOV	  	0.3694	  	A
														
	 PUBLIC HEALTH SERVICE
	  	070102PHS	  	6733625801	  	Histex CT	  	15	  		  	07/01/06	  	09/30/06	  	0.3694	  	—  	  	PHS	  	GOV	  	0.3694	  	A
														
	 WELLPOINT
	  	011204WLP	  	6733625801	  	Histex CT	  		  		  	10/01/03	  	09/30/06	  	0.1200	  	—  	  	WLP	  	PBM	  	0.1200	  	A
														
	Histex HC	  		  		  		  		  		  		  		  		  		  		  		  		  	
														
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733691016	  	Histex HC	  	1	  		  	04/01/03	  	12/31/06	  	0.1000	  	0.0300	  	PCS	  	PBM	  	0.1300	  	A
														
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733691016	  	Histex HC	  	2	  		  	04/01/03	  	12/31/06	  	0.1200	  	0.0300	  	PCS	  	PBM	  	0.1500	  	A
														
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733691016	  	Histex HC	  	3	  		  	04/01/03	  	12/31/06	  	0.1200	  	0.0300	  	PCS	  	PBM	  	0.1500	  	A
														
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733691016	  	Histex HC	  	4	  		  	04/01/03	  	12/31/06	  	0.1400	  	0.0300	  	PCS	  	PBM	  	0.1700	  	A
														
	 AMERICAN PHARMACY CO-OP
	  	070105APC	  	6733691016	  	Histex HC	  		  		  	07/01/05	  	12/31/06	  	0.0700	  	—  	  	APC	  	RET	  	0.0700	  	A
														
	 API
	  	070105API	  	6733691016	  	Histex HC	  		  		  	07/01/05	  	12/31/06	  	0.0700	  	0.0200	  	API	  	RET	  	0.0900	  	A
														
	 APN
	  	070105APN	  	6733691016	  	Histex HC	  		  		  	07/01/05	  	06/30/06	  	0.0700	  	0.0200	  	APN	  	GPO	  	0.0900	  	A
														
	 FEDERAL SUPPLY SCHEDULE
	  	090103FSS	  	6733691016	  	Histex HC	  		  		  	09/01/03	  	12/31/99	  	0.2601	  	—  	  	FSS	  	GOV	  	0.2600	  	A
														
	 MCKESSON
	  	031504MCK	  	6733691016	  	Histex HC	  		  		  	03/15/04	  	12/31/99	  	0.2430	  	—  	  	MCK	  	WHLS	  	0.2430	  	A
														
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733691016	  	Histex HC	  	2	  	MailOrder	  	07/01/03	  	06/30/07	  	0.2500	  	—  	  	MMH	  	PBM	  	0.2500	  	A
														
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733691016	  	Histex HC	  	3	  	Medicare	  	03/15/04	  	06/30/06	  	0.2310	  	—  	  	MMH	  	PBM	  	0.2310	  	A
														
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733691016	  	Histex HC	  		  		  	07/01/03	  	06/30/07	  	0.2200	  	0.0300	  	MMH	  	PBM	  	0.2500	  	A
														
	 MHA
	  	100105MHA	  	6733691016	  	Histex HC	  		  		  	10/01/05	  	09/30/07	  	0.1400	  	0.0300	  	MHA	  	GPO	  	0.1700	  	A
														
	 NC MUTUAL
	  	010106NCM	  	6733691016	  	Histex HC	  		  		  	01/01/05	  	06/30/06	  	0.0500	  	—  	  	NCM	  	WHLS	  	0.0500	  	A

																											
	 OPTISOURCE
	  	050106OPT	  	6733691016	  	Histex HC	  		  		  	05/01/06	  	12/31/06	  	0.1100	  	—  	  	OPT	  	GPO	  	0.1100	  	A
	 PBA HEALTH
	  	112205PBA	  	6733691016	  	Histex HC	  		  		  	11/22/05	  	12/31/07	  	0.0800	  	0.0200	  	PBA	  	GPO	  	0.1000	  	A
	 PUBLIC HEALTH SERVICE
	  	070102PHS	  	6733691016	  	Histex HC	  	14	  		  	04/01/06	  	06/30/06	  	0.3367	  	—  	  	PHS	  	GOV	  	0.3367	  	A
	 PUBLIC HEALTH SERVICE
	  	070102PHS	  	6733691016	  	Histex HC	  	15	  		  	07/01/06	  	09/30/06	  	0.5275	  	—  	  	PHS	  	GOV	  	0.5275	  	A
	 WELLPOINT
	  	011204WLP	  	6733691016	  	Histex HC	  		  		  	10/01/03	  	09/30/06	  	0.1200	  	—  	  	WLP	  	PBM	  	0.1200	  	A
														
	Histex Liquid	  		  		  		  		  		  		  		  		  		  		  		  		  	
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733627516	  	Histex Liquid	  	1	  		  	04/01/03	  	12/31/06	  	0.1000	  	0.0300	  	PCS	  	PBM	  	0.1300	  	A
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733627516	  	Histex Liquid	  	2	  		  	04/01/03	  	12/31/06	  	0.1100	  	0.0300	  	PCS	  	PBM	  	0.1400	  	A
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733627516	  	Histex Liquid	  	3	  		  	04/01/03	  	12/31/06	  	0.1100	  	0.0300	  	PCS	  	PBM	  	0.1400	  	A
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733627516	  	Histex Liquid	  	4	  		  	04/01/03	  	12/31/06	  	0.1200	  	0.0300	  	PCS	  	PBM	  	0.1500	  	A
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733627516	  	Histex Liquid	  	5	  	Medicare	  	06/01/04	  	12/31/06	  	0.3000	  	0.0300	  	PCS	  	PBM	  	0.3300	  	A
	 FEDERAL SUPPLY SCHEDULE
	  	090103FSS	  	6733627516	  	Histex Liquid	  		  		  	09/01/03	  	12/31/99	  	0.2885	  	—  	  	FSS	  	GOV	  	0.2600	  	A
	 MCKESSON
	  	031504MCK	  	6733627516	  	Histex Liquid	  		  		  	03/15/04	  	12/31/99	  	0.2430	  	—  	  	MCK	  	WHLS	  	0.2430	  	A
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733627516	  	Histex Liquid	  	2	  	MailOrder	  	07/01/03	  	06/30/07	  	0.2500	  	—  	  	MMH	  	PBM	  	0.2500	  	A
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733627516	  	Histex Liquid	  	3	  	Medicare	  	03/15/04	  	06/30/06	  	0.2310	  	—  	  	MMH	  	PBM	  	0.2310	  	A
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733627516	  	Histex Liquid	  		  		  	07/01/03	  	06/30/07	  	0.2200	  	0.0300	  	MMH	  	PBM	  	0.2500	  	A
	 MHA
	  	100105MHA	  	6733627516	  	Histex Liquid	  		  		  	10/01/05	  	09/30/07	  	0.1400	  	0.0300	  	MHA	  	GPO	  	0.1700	  	A
	 OPTISOURCE
	  	050106OPT	  	6733627516	  	Histex Liquid	  		  		  	05/01/06	  	12/31/06	  	0.0200	  	—  	  	OPT	  	GPO	  	0.0200	  	A
	 PUBLIC HEALTH SERVICE
	  	070102PHS	  	6733627516	  	Histex Liquid	  	14	  		  	04/01/06	  	06/30/06	  	0.1831	  	—  	  	PHS	  	GOV	  	0.1831	  	A
	 PUBLIC HEALTH SERVICE
	  	070102PHS	  	6733627516	  	Histex Liquid	  	15	  		  	07/01/06	  	09/30/06	  	0.1831	  	—  	  	PHS	  	GOV	  	0.1831	  	A
	 WELLPOINT
	  	011204WLP	  	6733627516	  	Histex Liquid	  		  		  	10/01/03	  	09/30/06	  	0.1200	  	—  	  	WLP	  	PBM	  	0.1200	  	A
														
	Histex PD	  		  		  		  		  		  		  		  		  		  		  		  		  	
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733625416	  	Histex PD	  	1	  		  	04/01/03	  	12/31/06	  	0.1000	  	0.0300	  	PCS	  	PBM	  	0.1300	  	A
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733625416	  	Histex PD	  	2	  		  	04/01/03	  	12/31/06	  	0.1200	  	0.0300	  	PCS	  	PBM	  	0.1500	  	A
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733625416	  	Histex PD	  	3	  		  	04/01/03	  	12/31/06	  	0.1200	  	0.0300	  	PCS	  	PBM	  	0.1500	  	A
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733625416	  	Histex PD	  	4	  		  	04/01/03	  	12/31/06	  	0.1400	  	0.0300	  	PCS	  	PBM	  	0.1700	  	A
	 AHOLD
	  	010106AHD	  	6733625416	  	Histex PD	  		  		  	01/01/06	  	12/31/06	  	0.2500	  	—  	  	AHD	  	RET	  	0.2500	  	A
	 APN
	  	070105APN	  	6733625416	  	Histex PD	  		  		  	07/01/05	  	06/30/06	  	0.0700	  	0.0200	  	APN	  	GPO	  	0.0900	  	A
	 EPIC PHARMACIES
	  	021506EPI	  	6733625416	  	Histex PD	  		  		  	02/15/06	  	03/31/07	  	0.2500	  	—  	  	EPI	  	GPO	  	0.2500	  	A
	 FEDERAL SUPPLY SCHEDULE
	  	090103FSS	  	6733625416	  	Histex PD	  		  		  	09/01/03	  	12/31/99	  	0.2600	  	—  	  	FSS	  	GOV	  	0.2600	  	A

  

 -2- 

																											
	 KROGER
	  	040106KRO	  	6733625416	  	Histex PD	  		  		  	04/01/06	  	12/31/06	  	0.2700	  	—  	  	KRO	  	RET	  	0.2700	  	A
	 MCKESSON
	  	031504MCK	  	6733625416	  	Histex PD	  		  		  	03/15/04	  	12/31/99	  	0.2430	  	—  	  	MCK	  	WHLS	  	0.2430	  	A
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733625416	  	Histex PD	  	2	  	MailOrder	  	07/01/03	  	06/30/07	  	0.2500	  	—  	  	MMH	  	PBM	  	0.2500	  	A
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733625416	  	Histex PD	  	3	  	Medicare	  	03/15/04	  	06/30/06	  	0.2310	  	—  	  	MMH	  	PBM	  	0.2310	  	A
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733625416	  	Histex PD	  		  		  	07/01/03	  	06/30/07	  	0.2200	  	0.0300	  	MMH	  	PBM	  	0.2500	  	A
	 MHA
	  	100105MHA	  	6733625416	  	Histex PD	  		  		  	10/01/05	  	09/30/07	  	0.1400	  	0.0300	  	MHA	  	GPO	  	0.1700	  	A
	 OPTISOURCE
	  	050106OPT	  	6733625416	  	Histex PD	  		  		  	05/01/06	  	12/31/06	  	0.1100	  	—  	  	OPT	  	GPO	  	0.1100	  	A
	 PBA HEALTH
	  	112205PBA	  	6733625416	  	Histex PD	  		  		  	11/22/05	  	12/31/07	  	0.2300	  	0.0200	  	PBA	  	GPO	  	0.2500	  	A
	 PEYTON/KROGER
	  	040106PEY	  	6733625416	  	Histex PD	  		  		  	04/01/06	  	12/31/06	  	0.2700	  	—  	  	PEY	  	RET	  	0.2700	  	A
	 PHARMACY SELECT
	  	010106PSE	  	6733625416	  	Histex PD	  		  		  	01/01/06	  	12/31/06	  	0.2500	  	—  	  	PSE	  	GPO	  	0.2500	  	A
	 PUBLIC HEALTH SERVICE
	  	070102PHS	  	6733625416	  	Histex PD	  	14	  		  	04/01/06	  	06/30/06	  	0.3720	  	—  	  	PHS	  	GOV	  	0.3720	  	A
	 PUBLIC HEALTH SERVICE
	  	070102PHS	  	6733625416	  	Histex PD	  	15	  		  	07/01/06	  	09/30/06	  	0.3720	  	—  	  	PHS	  	GOV	  	0.3720	  	A
	 WELLPOINT
	  	011204WLP	  	6733625416	  	Histex PD	  		  		  	10/01/03	  	09/30/06	  	0.1200	  	—  	  	WLP	  	PBM	  	0.1200	  	A
														
	Histex SR	  		  		  		  		  		  		  		  		  		  		  		  		  	
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733608901	  	Histex SR	  	1	  		  	04/01/03	  	12/31/06	  	0.1000	  	0.0300	  	PCS	  	PBM	  	0.1300	  	A
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733608901	  	Histex SR	  	2	  		  	04/01/03	  	12/31/06	  	0.1100	  	0.0300	  	PCS	  	PBM	  	0.1400	  	A
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733608901	  	Histex SR	  	3	  		  	04/01/03	  	12/31/06	  	0.1100	  	0.0300	  	PCS	  	PBM	  	0.1400	  	A
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733608901	  	Histex SR	  	4	  		  	04/01/03	  	12/31/06	  	0.1200	  	0.0300	  	PCS	  	PBM	  	0.1500	  	A
	 ADVANCE PCS HEALTH (CareMark)
	  	040103PCS	  	6733608901	  	Histex SR	  	5	  	Medicare	  	06/01/04	  	12/31/06	  	0.1700	  	0.0300	  	PCS	  	PBM	  	0.2000	  	A
	 AHOLD
	  	010106AHD	  	6733608901	  	Histex SR	  		  		  	01/01/06	  	12/31/06	  	0.2000	  	—  	  	AHD	  	RET	  	0.2000	  	A
	 AMERICAN PHARMACY CO-OP
	  	070105APC	  	6733608901	  	Histex SR	  		  		  	07/01/05	  	12/31/06	  	0.2000	  	—  	  	APC	  	RET	  	0.2000	  	A
	 API
	  	070105API	  	6733608901	  	Histex SR	  		  		  	07/01/05	  	12/31/06	  	0.2000	  	0.0200	  	API	  	RET	  	0.2200	  	A
	 APN
	  	070105APN	  	6733608901	  	Histex SR	  		  		  	07/01/05	  	06/30/06	  	0.0700	  	0.0200	  	APN	  	GPO	  	0.0900	  	A
	 EPIC PHARMACIES
	  	021506EPI	  	6733608901	  	Histex SR	  		  		  	02/15/06	  	03/31/07	  	0.2000	  	—  	  	EPI	  	GPO	  	0.2000	  	A
	 FEDERAL SUPPLY SCHEDULE
	  	090103FSS	  	6733608901	  	Histex SR	  		  		  	09/01/03	  	12/31/99	  	0.2887	  	—  	  	FSS	  	GOV	  	0.2600	  	A
	 KROGER
	  	040106KRO	  	6733608901	  	Histex SR	  		  		  	04/01/06	  	12/31/06	  	0.2700	  	—  	  	KRO	  	RET	  	0.2700	  	A
	 MCKESSON
	  	031504MCK	  	6733608901	  	Histex SR	  		  		  	03/15/04	  	12/31/99	  	0.2430	  	—  	  	MCK	  	WHLS	  	0.2430	  	A
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733608901	  	Histex SR	  	2	  	MailOrder	  	07/01/03	  	06/30/07	  	0.2500	  	—  	  	MMH	  	PBM	  	0.2500	  	A
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733608901	  	Histex SR	  	3	  	Medicare	  	03/15/04	  	06/30/06	  	0.1309	  	—  	  	MMH	  	PBM	  	0.1309	  	A
	 MEDCO HEALTH SOLUTIONS
	  	070103MMH	  	6733608901	  	Histex SR	  		  		  	07/01/03	  	06/30/07	  	0.2200	  	0.0300	  	MMH	  	PBM	  	0.2500	  	A
	 MHA
	  	100105MHA	  	6733608901	  	Histex SR	  		  		  	10/01/05	  	09/30/07	  	0.1400	  	0.0300	  	MHA	  	GPO	  	0.1700	  	A

  

 -3- 

																											
	 NC MUTUAL
	  	010106NCM	  	6733608901	  	Histex SR	  		  		  	01/01/05	  	06/30/06	  	0.0500	  	—  	  	NCM	  	WHLS	  	0.0500	  	A
	 OPTISOURCE
	  	050106OPT	  	6733608901	  	Histex SR	  		  		  	05/01/06	  	12/31/06	  	0.1100	  	—  	  	OPT	  	GPO	  	0.1100	  	A
	 PBA HEALTH
	  	112205PBA	  	6733608901	  	Histex SR	  		  		  	11/22/05	  	12/31/07	  	0.2300	  	0.0200	  	PBA	  	GPO	  	0.2500	  	A
	 PEYTON/KROGER
	  	040106PEY	  	6733608901	  	Histex SR	  		  		  	04/01/06	  	12/31/06	  	0.2700	  	—  	  	PEY	  	RET	  	0.2700	  	A
	 PHARMACY SELECT
	  	010106PSE	  	6733608901	  	Histex SR	  		  		  	01/01/06	  	12/31/06	  	0.2000	  	—  	  	PSE	  	GPO	  	0.2000	  	A
	 PUBLIC HEALTH SERVICE
	  	070102PHS	  	6733608901	  	Histex SR	  	14	  		  	04/01/06	  	06/30/06	  	0.4500	  	—  	  	PHS	  	GOV	  	0.4500	  	A
	 PUBLIC HEALTH SERVICE
	  	070102PHS	  	6733608901	  	Histex SR	  	15	  		  	07/01/06	  	09/30/06	  	0.4500	  	—  	  	PHS	  	GOV	  	0.4500	  	A
	 WELLPOINT
	  	011204WLP	  	6733608901	  	Histex SR	  		  		  	10/01/03	  	09/30/06	  	0.1200	  	—  	  	WLP	  	PBM	  	0.1200	  	A

  

 -4- 

 Article 6.7 Seller Disclosure Schedule 
 Exhibit A Inventory at Distribution Center as of October 3, 2006 

 Trade Stock in DDN as of 10/03/2006 
  

												
	 NDC Description
	  	NDC	  	LotExpDate	  	Lot#	  	Qty	  	Value
	 Histex HC
	  	6733691016	  	20070731	  	2065	  	414	  	$	2,182
		  		  	20080331	  	1376	  	3,831	  	$	20,189
	 Histex HC Total
	  		  		  		  	4,245	  	$	22,371
	 Histex Liquid
	  	6733627516	  	20090131	  	24	  	2244	  	$	6912
		  		  	20090228	  	804	  	3,972	  	$	12,234
	 Histex Liquid Total
	  		  		  		  	6,312	  	$	19,145
	 Histex PD
	  	6733625416	  	20070630	  	1845	  	587	  	$	1,597
		  		  	20080331	  	1606	  	3,932	  	$	10,695
	 Histex PD Total
	  		  		  		  	4,519	  	$	12,292
	 Histex SR
	  	6733608901	  	20071130	  	6087	  	1,497	  	$	7,336
		  		  		  		  		  	 	 
	 Total Histex
	  		  		  		  		  	$	61,143
		  		  		  		  		  	 	 

 Schedule A 
 Rivers Edge Return Liability Calculation 

												
	 	  	Lot	  	Qty	  	Expiry Date	  	Lot
Qty	  	Rivers
Edge
Liability	 
	 Histex SR 100ct
	  	6087	  	1497	  	11/30/2007	  	4885	  	30.64	%
	 Histex Liq
	  	24	  	2244	  	1/31/2009	  	3985	  	56.31	%
	 Histex Liq
	  	804	  	3972	  	2/28/2009	  	3996	  	99.40	%

 Exhibit B Wholesaler Inventory 
 Inventory at McKesson, Cardinal and Amerisource as of August 30, 2006 
  

									
	 	  	Cardinal	  	Amerisource	  	McKesson	  	Total
	 Histex SR Capsules
	  	144	  	129	  	320	  	593
	 Histex HC Liquid
	  	158	  	86	  	534	  	778
	 Histex Pd Liquid
	  	113	  	24	  	321	  	458
	 Histex Liquid
	  	74	  	40	  	164	  	278

  

 -2- 

 Exhibit C 
 Products and NDC Codes 
  

			
	 Products
	  	 NDC Codes

		
	 Histex Liquid
	  	 67336-0275-16

		
	 Histex HC
	  	 67336-0910-16

		
	 Histex PD
	  	 67336-0254-16

		
	 Histex SR
	  	 67336-0089-01

		
	 Histex CT
	  	 67336-0258-01

  

 -3-

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00112-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00112-of-00352.parquet"}]]