Document:

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                                                              Exhibit 10.49

October 1, 2004

Mr. Michael Morrison
[To Address on File
With Human Resources
Department]

Dear Mr. Morrison:

The terms and understanding of your consultancy for Allied World Assurance
Holdings, Ltd is that you will work exclusively for Allied World Assurance
Holdings, Ltd assisting, among other things with the organizational development
and structure.

Allied World Assurance Holdings, Ltd will pay you a retainer of $12,500 per
month for your services, and such payments will be paid on the 30th of each
month.

Allied World Assurance Holdings, Ltd will also pay all customary expenses
associated with your work. When practical, please submit expenses monthly,
within 30 days of being incurred.

Please confirm that these arrangements are satisfactory by signing and retaining
this copy for your records.

Sincerely,

/s/ Scott Carmilani

Scott Carmilani
President and CEO

Signature:  /s/ Michael Morrison          Date:             10/1/04
            ------------------------------       -------------------------------<PAGE>
                                                                   Exhibit 10.19

[AMICUS LOGO]
AMICUS
Therapeutics--------------------------------------------------------------------

May 12, 2006

Mr. Mark Simon
37 Kennedy Lane
Morristown NJ. 07960

Dear Mark:

         On behalf of Amicus Therapeutics, Inc. (the "Company"), I am pleased to
confirm our offer to you for the position of Senior Vice President Business
Development reporting to me. Your start date will be mutually agreed upon but no
later then June 12, 2006. With this offer you agree to devote no less then 30
hrs per week of your time and professional efforts to Amicus Therapeutics.

         Prior to the commencement of your employment you will be required to
execute the Company's Confidentiality, Disclosure and Non-Competition Agreement.
A copy of this agreement is attached. In addition, as a condition of employment
Amicus requires a pre-employment drug screening.

         In consideration for all your services to be rendered to the Company
your annual base salary will be $100,000, to be paid bi-weekly in accordance
with the Company's payroll practices. Upon the completion of mutually agreed
upon individual goals and objectives as well as the achievement of specific
Company goals, you will be eligible to receive a year end bonus target of 25% of
your base salary, prorated for your date of hire, minus customary deductions.

         Upon approval by the Board of Directors, you will receive an incentive
stock option to purchase 375,000 shares of the Company's common stock, par value
$.01 per share (the "Common Stock") pursuant to a stock option agreement in form
and substance acceptable to the Company. The options will become exercisable
over a four-year period as follows: 25% on the first anniversary of the date of
grant, and the remaining 75% in equal monthly increments thereafter. The
exercise price of the options will be the fair market value of the Company's
common stock on the date of grant. Shares issuable upon exercise of each option
will be subject to certain transfer restrictions including the right of first
refusal. Additionally, exercise of the options will be governed in accordance
with the provisions of the Company's stock option plan.

         You will be eligible to participate in the Company's health benefits
program and are eligible to participate in the Company's 401(k) as well as any
other employee benefit plan(s) that are generally made available by the Company
to its employees from time to time when and as the Company may make them
available.

--------------------------------------------------------------------------------
 6 Cedar Brook Drive   Cranbury, NJ 08512    T: 609-662-2000     F: 609-662-2001
                           www.amicustherapeutics.com
<PAGE>
Mr. Mark Simon
May 12, 2006
Page #2 of 3

         You will be eligible for paid Company holidays as outlined in our
Holiday Policy and you will be eligible for twenty (20) days paid vacation,
three weeks during the year and one between Christmas and New Years. Vacation
accrues on a monthly basis. Because the Company expects to regularly review its
benefit programs to keep them up to date and competitive, these programs are
subject to periodic adjustments so that certain features may be added, modified
or deleted over time.

         If you are terminated without Cause, you will be eligible for a
continuation of six (6) months salary, an additional six (6) months of option
vesting, plus payment of a bonus payment equal to the bonus earned in the
preceding year. "Cause" means for any of the following reasons: (i) willful or
deliberate misconduct by you that materially damages the company; (ii)
misappropriation of company assets; (iii) conviction of or a plea of guilty or
"no contest" to, a felony; or (iv) any willful disobedience of the lawful and
unambiguous instructions of the CEO of the company; provided that the CEO has
given you written notice of such disobedience or neglect and you have failed to
cure such disobedience or neglect within a period reasonable under the
circumstances.

         If there is a Change in Control Event and you resign for Good Reason or
are terminated without Cause within six months of such Change in Control Event,
then (i) you will be entitled to receive a continuation of twelve (12) months
salary, plus payment of a bonus payment equal to the bonus earned in the
preceding year and (ii) all unvested stock options will have their remaining
vesting schedule accelerated so that all stock options are fully vested.

         "Change in Control Event" means any of the following: (i) any person or
entity (except for a current stockholder) becomes the beneficial owner of
greater than 50% of the then outstanding voting power of the company; (ii) a
merger or consolidation with another entity where the voting securities of the
company outstanding immediately before the transaction constitute less than a
majority of the voting power of the voting securities of the company or the
surviving entity outstanding immediately after the transaction, or (iii) the
sales or disposition of all or substantially all of the company's assets. "Good
Reason" means (i) a change in your position with the company or its successor
that materially reduces your title, duties or level of responsibility; or (ii)
the relocation of the company or its successor greater than 50 miles away from
the then current location of the company's principal offices.

         Your right to receive accelerated vesting and severance payments
pursuant to the preceding three paragraphs shall be subject to the condition
that you execute a full release and waiver of all claims against the company and
related parties, in a form acceptable to the company.

         There is a two (2) year term on this agreement that will automatically
renew unless either party provides a thirty (30) day notice of termination.
<PAGE>

Mr. Mark Simon
May 12, 2006
Page #3 of 3

         In accordance with the Immigration and Naturalization Control Act, all
new employees must provide documentation that they have the legal right to work
in the United States. A copy of Form I-9 and a list of the acceptable documents
confirming your right to work in the United States are also attached for your
convenience.

         To indicate your acceptance of our offer, please sign one copy of this
letter in the space indicated below and return it to the attention of Nicole
Schaeffer, Vice President of Human Resources & Leadership Development by May 19,
2006. Acceptance of this offer constitutes your agreement with all of the above
terms and conditions of employment with Amicus Therapeutics, Inc., and
constitutes agreement to conform to Amicus Therapeutics, Inc. rules and
procedures. By signing below, you agree that no other promises, express or
implied, have been made to you either verbally or in writing and that no further
modifications to these terms and conditions will be effective except by a
written agreement signed by the Chief Executive Officer of the Company and you.

         The formality of this letter not withstanding, I extend my personal
best wishes and sincere pleasure that you are joining our team. I look forward
to working with you.

Sincerely,

John F. Crowley
President & CEO

I accept the offer of employment under the terms and conditions stated above. No
other promises, express or implied, have been made to me either verbally or in
writing.

By:                                                Date:
   -------------------------------------------         -------------------------
                  Mark Simon<PAGE>

                                                                    Exhibit 10.1

                      Amendments to the Visteon Corporation
               Supplemental Executive Retirement Plan (the "SERP")

                                  June 15, 2006

Amendments to the SERP Traditional Program

A. The component of the SERP which generally is applicable to employees who had
commenced participation in the SERP prior to January 1, 2002 (the "SERP
Traditional Program") is amended, effective June 30, 2006, in the following
respects:

     1. Employment after June 30, 2006 will not be recognized for purposes of
determining an employee's Credited Service to the extent that service is used to
calculate the amount of any retirement benefit to which a covered employee is
entitled.

     2. An employee's Final Five Year Average Base Salary and Eligibility
Service will be determined in accordance with the terms of the SERP Traditional
Program, taking into account the employee's eligible Monthly Base Salary (as
defined in the SERP Traditional Program) through the first date on which the
employee retires from or otherwise ceases to be employed in a Covered Employment
Classification (as defined in the SERP Traditional Program) with the Corporation
and its affiliates.

     3. Covered Employment Classification (as defined in the SERP Traditional
Program) shall include employees who were classified as Senior Leaders on
January 1, 2006 and subsequently reclassified as Senior Directors due to the
elimination of the Senior Leader classification and not as a result of a
demotion or change in job responsibilities.

     4. The Applicable Percentage set forth in Section 2.03 (a) of the SERP
Traditional Program shall remain .20% for employees who were classified as
Senior Leaders on January 1, 2006 and subsequently reclassified as Executive
Leaders due to the elimination of the Senior Leader classification and not as a
result of promotion or a change in job responsibilities. The Applicable
Percentage for such Senior Leaders who were reclassified as Senior Directors
subsequent to January 1, 2006 shall be .20%.

     5. A participant in the SERP Traditional Program who terminates employment
after June 30, 2006 will be eligible to receive a benefit under the SERP
Traditional Program upon attaining a SERP Eligibility Date (as defined in the
SERP BalancePlus Program.)

Amendments to the SERP BalancePlus Program

B. The component of the SERP which generally is applicable to employees who
commenced participation in the SERP after December 31, 2001 (the "SERP
BalancePlus Program") is amended, effective June 30, 2006, in the following
respects:

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     1. Employees of the Corporation or a participating affiliate who are active
participants in the SERP Traditional Program on June 30, 2006 (each, an
"Affected Employee") will begin participation in the SERP BalancePlus Program on
July 1, 2006.

     2. An Affected Employee's benefit under the SERP BalancePlus Program will
be determined solely by reference to the Affected Employee's Compensation and
Final Average Compensation (as such terms are defined in the SERP BalancePlus
Program).

     3. Final Average Compensation for purposes of determining pension equity
accruals shall be the sum of (i) final average compensation as defined in the
BalancePlus Program as in effect on June 29, 2006, determined without regard to
the compensation limitation of Code Section 401(a)(17) of the Internal Revenue
Code, and (ii) the average of the three highest consecutive Annual Incentive
amounts paid to the participant (or that would have been paid to the participant
except for the participant's election to defer all or a portion of such
payment.)

     4. The minimum target incentive level required for at least five years in
order to attain a SERP Eligibility Date (as defined in the SERP BalancePlus
Program) shall be reduced to 30% from 40%.

                                        2

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