Document:

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                                                                   EXHIBIT 10.22

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                                SUPPLY AGREEMENT
                                     BETWEEN
                                 CIMA LABS INC.
                                       AND
                       AMERICAN HOME PRODUCTS CORPORATION
                              ESI LEDERLE DIVISION

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                                SUPPLY AGREEMENT

                  THIS SUPPLY AGREEMENT is signed this 14th day of January 2000
between CIMA LABS., a corporation organized and existing under the laws of the
State of with offices located at 10000 Valley View Road, Eden Prairie, Minnesota
55344-9361 (hereafter, together with its Affiliates, referred to "CIMA"), and
American Home Products Corporation (acting through its division, ESI Lederle), a
corporation organized and existing under the laws of the State of Delaware with
offices located at 130 North Radnor-Chester Road, St. Davids, Pennsylvania 19087
("ESI").

                                    ARTICLE I
                                   DEFINITIONS

         1.1 [...***...]

         1.2 ADVERSE DRUG EXPERIENCE means the definition in the current 21 CFR
" Sections 312.32 and 314.80, as in effect from time to time.

         1.3 AFFILIATE means (i) any Person which at the time of determination
is directly or indirectly controlled by any party hereto; (ii) any Person which
at the time of determination directly or indirectly controls any party hereto;
or (iii) any Person which is under the direct or indirect control of any such
Person as described in subparagraphs

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(i) or (ii). "Control" shall in this Section mean ownership of greater than
fifty percent (50%) of the voting stock or other voting interests in the Person
in question. For purposes of this Agreement, Immunex Corporation shall not be
considered to be an affiliate of ESI.

         1.4 AGENCY means any governmental regulatory authority responsible for
granting approvals, including Pricing Approvals, for the sale of a Product in a
country in the Territory.

         1.5 COMMERCIALLY REASONABLE EFFORTS means efforts and resources
normally used by a party for a compound or product owned by it or to which it
has rights, which is of similar market potential at a similar stage in its
product life, taking into account the competitiveness of the marketplace, the
proprietary position of the compound or product, the regulatory structure
involved, the profitability of the applicable products, and other relevant
factors. It is anticipated that the level of efforts and resources may change at
different times during the product life cycle of a compound or product.

         1.6 CONTROL OR CONTROLLED in the context of intellectual property
rights means rights to intellectual property sufficient to allow a grant of
rights without any obligation to any Third Party.

         1.7 [...***...]

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         1.8 DEVELOPMENT AND LICENSE AGREEMENT means the Development and
License Agreement between the parties signed contemporaneously with this
Agreement

         1.9 EFFECTIVE DATE means the effective date of the Development and
License Agreement.

         1.10 EXTENDED TERM shall have the meaning set forth in Section 9.1.

         1.11 FDA means the United States Food and Drug Administration, or any
successor thereto.

         1.12 GOOD MANUFACTURING PRACTICE OR GMP means the current standards for
the manufacture of pharmaceuticals, as set forth in the United States Federal,
Food, Drug and Cosmetics Act and applicable regulations promulgated thereunder,
as amended from time to time, and such standards of good manufacturing practices
as are required by the European Union and other organizations and governmental
agencies in countries in which Product is intended to be sold, to the extent
such standards are not inconsistent with United States GMP.

         1.13 INITIAL TERM shall have the meaning set forth in Section 9.1

         1.14 LAUNCH DATE means the date of first commercial shipment of a
Product by ESI or its Affiliates or their respective subdistributors of Product
to Third Parties in a country of the Territory.

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         1.15 MAJOR COUNTRY means any of the United States, Germany, or the
United Kingdom. The foregoing countries may also collectively be referred to as
Major Countries.

         1.16 NDA means a New Drug Application, as defined in the United States
Food, Drug and Cosmetic Act, as amended, and applicable FDA rules and
regulations.

         1.17 PERSON shall mean an individual, a corporation, a partnership, an
association, a trust or other entity or organization, including a government or
political subdivision or an agency thereof.

         1.18 PRICING APPROVAL means any approval for price or reimbursement as
may be necessary or appropriate as a prerequisite for marketing Product in a
particular country of the Territory.

         1.19 PRODUCT means rapid dissolving tablets containing 10 milligrams
Active Ingredient meeting the Specifications.

         1.20 REGULATORY APPROVAL means the product license or marketing
approval necessary as a prerequisite for marketing Product in a particular
country in the Territory.

         1.21 REGULATORY DOCUMENTS means all regulatory submissions, Regulatory
Approvals, and Pricing Approvals.

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         1.22 SPECIFICATIONS means the initial specifications for the Product as
set forth in Exhibit A hereto, as may be amended from time to time by the
parties in the course of Product development and in accordance with the
regulatory submissions and/or Regulatory Approvals, or as otherwise required by
regulatory authorities.

         1.23 TECHNICAL INFORMATION means (a) techniques and data, including
ideas, inventions (including patentable inventions), practices, methods,
knowledge, know-how, trade secrets, skill, experience, documents, apparatus,
clinical and regulatory strategies, test data, including pharmacological,
toxicological and clinical test data, analytical and quality control data,
manufacturing, patent data or descriptions relating to Product, and (b) chemical
formulations, compositions of matter, product samples and assays relating to
Product.

         1.24 TERM shall have the meaning set forth in Section 9.1

         1.25 TERRITORY means the world.

         1.26 THIRD PARTY means any Person other than a party to this Agreement
or an Affiliate of a party to this Agreement.

                                   ARTICLE II
                            SUPPLY AND MANUFACTURING

         2.1 MANUFACTURING During the Term of this Agreement, CIMA shall
manufacture and supply ESI with, and ESI shall purchase from CIMA Product in

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accordance with the terms specified in this Article II. Subject to Section 2.9,
ESI shall exclusively purchase all of ESI's requirements of Product from CIMA
and CIMA shall exclusively supply Product to ESI.

         2.2 [...***...]

         2.3 FORECASTS

         (a) [...***...], ESI shall provide to CIMA a non-binding rolling three
(3) year Product forecast (based on calendar years and updated at least
semi-annually) for long-term manufacturing planning purposes.

         (b) During the Term of this Agreement, ESI shall provide CIMA on a
calendar basis, with a non-binding one (1) year rolling forecast, providing CIMA
with a written estimate of the quantities of Product required during the next
four (4) calendar half years. Each such quarterly estimate shall contain an
update of the immediately preceding estimate with respect to the calendar
quarters referred to in such preceding estimate.

         2.4 FIRM ORDERS

         (a ) [...***...]

         (b) Notwithstanding the foregoing, CIMA has the right to satisfy ESI's
firm order requirements pursuant to this Article II by supplying ESI with
Product in full batch

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quantities provided that CIMA may round up or down ESI's actual order for
Product to the nearest full batch.

         2.5      LIMITS ON FIRM ORDERS

                   If a firm order made pursuant to Section 2.4 is greater than
one hundred fifty percent (150%) of the one (1) year rolling forecast received
by CIMA for such ninety (90) day period, then CIMA shall use Commercially
Reasonable Efforts, but shall not be obligated, to ship that portion of the
excess over one hundred fifty percent (150%).

         2.6 CANCELLATIONS OF ORDERS If ESI cancels a firm order made pursuant
to Section 2.4, then ESI shall reimburse CIMA for all costs incurred by CIMA as
a result of such cancellation of such order, including materials, labor, work in
progress, obsolete inventory disposal and overhead; but this obligation shall
not cover capital costs.

         2.7 PAYMENT TERMS

         (a) [...***...]

         (b) [...***...]

         (c) In the event the Actual Amount for Product purchased by ESI in a
calendar half year is less than the Estimated Amount for that calendar half
year, then CIMA shall pay to ESI such difference amount with CIMA's report for
that calendar half

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year. In the event the Actual Amount for Product purchased by ESI in a calendar
half year is greater than the Estimated Amount for that calendar half year, then
ESI shall pay to CIMA such greater amount within fourteen (14) days of ESI's
receipt of CIMA's invoice for such amount with regard to ESI's purchases of
Product in that calendar half year.

         2.8 QUALITY ASSURANCE

             (a) Prior to the shipment of Product to ESI, CIMA shall test
         representative samples of each of the batch(es) to be shipped in
         accordance with validated, approved methods of analysis defined in the
         Specifications. CIMA shall provide ESI with a Certificate of Analysis
         for each batch of Product shipped to ESI stating that the Product so
         shipped conforms to the Specifications. The Certificate of Analysis
         shall be in a format agreed upon by the parties.

             (b) CIMA shall retain production samples and batch records from
         each batch of Product for the longer of (i) five (5) years after the
         manufacture of each such batch of Product or (ii) the time period
         required under GMP. Upon request, CIMA shall provide ESI's Quality
         Control Department with production samples of Product and/or copies of
         completed Batch records.

             (c) Master batch process documentation will be prepared and
         approved by CIMA as per its normal procedures. The parties agree that

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         deviations from master batch process documentation may be necessary
         from time to time. Such deviations shall be discussed with ESI before
         any proposed shipment of Product. Individual batch process
         documentation shall be photocopied from the approval master and issued
         for each batch as per CIMA's routine system. Original batch records
         will be filed securely by CIMA. CIMA will perform all in-process
         control tests demanded by the approved batch process.

             (d) ESI shall have the right to test Product to verify compliance
         with Specifications and applicable Regulatory Approvals and CIMA shall
         supply ESI with its testing procedures. ESI may, by written notice
         provided to CIMA within sixty (60) days of ESI's receipt of a shipment
         of Product, reject all or part of such shipment of Product if, based
         upon the testing of such Product conducted under this Section 2.8, such
         Product does not comply with the Specifications or applicable
         Regulatory Approvals. If ESI fails to notify CIMA within such sixty
         (60) day period, that it is rejecting such Product, ESI shall be deemed
         to have accepted such Product.

             (e) If CIMA, after good faith consultation with ESI, disputes any
         finding by ESI that Product does not comply with the Specifications or
         applicable Regulatory Approvals, samples of such Product shall be
         forwarded to a Third Party jointly selected by ESI and CIMA for
         analysis, which analysis shall be

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         performed in compliance with applicable regulatory requirements. The
         findings of such Third Party regarding whether Product complies with
         the Specifications and the applicable Regulatory Approvals shall be
         binding upon the parties for purposes of this Section 2.8. The cost of
         such analysis by such Third Party shall be borne by the party whose
         findings differed from those generated by such Third Party.

             (f) If as determined in accordance with this Section 2.8, a
         shipment of Product does not conform to the Specifications or
         applicable Regulatory Approvals, CIMA shall replace such shipment free
         of charge with a substitute shipment which meets such Specifications
         and applicable Regulatory Approvals according to the following time
         frame: If the Product is in inventory then conforming Product will be
         shipped so as to arrive as soon as practicable. If the Product is not
         in inventory, CIMA will take all reasonable steps to ensure expeditious
         manufacture of conforming Product which will be shipped on the next
         shipping day after completion of manufacture so as to arrive as soon as
         possible thereafter. In the event that testing at ESI indicates that
         Product does not conform with Specifications or applicable Regulatory
         Approvals: (i) ESI shall immediately notify CIMA (ii) ESI and CIMA
         shall mutually agree on an investigation program to determine the cause
         of the discrepancy and the

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         outcome of this investigation shall be used to determine disposition of
         the batch; (iii) where appropriate, given the timetable for the agreed
         upon investigation program, CIMA shall take all reasonable steps to
         ensure expeditious manufacture and shipment of conforming Product; and
         (iv) shipment of such replacement Product shall take place the next
         shipping day following completion of analytical work to demonstrate
         conformance with Specifications and applicable Regulatory Approvals.
         Shipment shall be by the quickest agreed route. At CIMA's expense and
         at ESI's sole option: the non-conforming shipment shall be (i) returned
         to CIMA; or (ii) disposed of by ESI, upon final determination in
         accordance with this Section 2.8 that it does not meet the
         Specifications or applicable Regulatory Approvals. If the
         non-conformity in the Product is due to a non-conformity of the Active
         Ingredient with the Specifications at the time of its delivery to CIMA,
         then the Replacement Product manufactured and shipped by CIMA under
         this Section 2.8 and the disposal of the non-conforming shipment shall
         be at the sole cost and expense of ESI.

         2.9 [...***...]

         2.10 NOTIFICATION OF INSPECTIONS Each party agrees to notify the other
within two (2) business days of its receipt of notification of any inquiries,
notifications, or inspection activity by any Agency, regulatory authority or
other authority in regard to

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or affecting Product. The recipient party shall provide a reasonable description
to the other party of any such governmental inquiries, notifications or
inspections promptly (but in no event later than five (5) calendar days) after
notification of completion of such visit or inquiry. The recipient party shall
furnish to the other party, (i) within two (2) business days after receipt any
report or correspondence issued by the Agency or regulatory authority in
connection with such visit or inquiry, including but not limited to, any FDA
Form 483, Establishment Inspection Reports or warning letters and (ii) at the
same time it provides to any Agency or regulatory authority, copies of any and
all documents, responses or explanations relating to items set forth above, in
each case purged only of trade secrets of the recipient that are unrelated to
the obligations under this Agreement or are unrelated to Product. In the event
such governmental agency or authority requests or requires any action to be
taken to address any citations, the recipient agrees, after consultation with
the other party, to take such action as necessary to address such citations ,
and agrees to cooperate with the other party with respect to any such citation
and/or action taken with respect thereto.

         2.11 INSPECTION BY ESI CIMA shall permit ESI (at its own expense) to
visit, during normal business hours and with reasonable advance notice CIMA's
manufacturing facility(ies) and warehouse, subject to the confidentiality
provisions of this Agreement, for the purposes of (a) observing the manufacture,
packaging, testing

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and warehousing of Product and to inspect for compliance with GMP's, applicable
regulatory requirements, the requirements of any applicable Regulatory
Approvals, and environmental monitoring, (b) solving technical or quality
problems, (c) examining the premises, equipment, procedures and personnel used
when producing, testing or controlling Product and (d) all books and records
relating to (a), (b) or (c). CIMA representatives shall be entitled to accompany
ESI representatives on any such inspection.

         2.12 ENVIRONMENTAL AND OTHER LAWS AND REGULATIONS

         (a) In carrying out its obligations under this Agreement, CIMA shall
comply with all applicable environmental, health and safety laws (current or as
amended or added, collectively "Laws"), and shall be solely responsible for
determining how to comply with same. CIMA represents and warrants that it has
the appropriate skills, personnel, equipment, permits or approvals necessary to
perform its services under this Agreement in compliance with all applicable
Laws.

         (b) CIMA shall notify ESI, in writing, no later than one (1) business
day after the event, of any circumstances, including the receipt of any notice,
warning, citation, finding, report or service of process, relating to compliance
with the Laws, or the occurrence of any release, spill, upset or discharge of
"Hazardous Active Ingredients" as defined by the Comprehensive Environmental
Response, Compensation and

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Liability Act of 1980, as amended, which relates to CIMA's ability to
manufacture or supply Product. ESI reserves the right to conduct an
environmental inspection of CIMA's facility(ies), during normal business hours
and with reasonable advance notice, for the purpose of determining compliance
with this Section 2.12(b), no more frequently than once per year during the term
hereof and under conditions of confidentiality as provided under Article VIII.
Upon CIMA's request, ESI shall share the results of any environmental inspection
with CIMA. Such inspection, if it occurs, does not relieve CIMA of its sole
obligation to comply with the Laws and does not constitute a waiver of any right
otherwise available to ESI.

         2.13 SPECIFICATIONS AMENDMENTS The Specifications shall be amended or
supplemented to comply with GMPs and to comply with any applicable Agency
directive and may also be amended or supplemented (including, without
limitation, for the purpose of incorporating improvements) from time to time. In
the event CIMA intends to amend the Specifications, ESI shall receive prompt
advance notice of any such amendments. No such amendment shall be filed with any
applicable Agency or otherwise become effective without the prior written mutual
approval of ESI and CIMA. In the event that after the parties have initially
agreed upon the Specifications, ESI requests that the Specifications be amended,
CIMA shall receive prompt advance notice of any such amendment for the purpose
of determining what, if any, impact the

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proposed amendment would have on the manufacture of Product for ESI hereunder
and ESI shall reimburse CIMA for the actual costs incurred by CIMA (provided
that such costs are approved in writing by ESI prior to being incurred by CIMA)
because such amendment requires changes to be made in the processes, equipment,
testing procedures, or components used to manufacture Product for ESI hereunder.
Such costs may include, without limitation, validation of new processes,
equipment and facilities, development of testing methods and start-up costs. Any
costs incurred by CIMA in implementing an amendment of the Specifications under
this Section shall not be included in CIMA's Direct Manufacturing Cost.

         2.14 APPROVAL FOR MANUFACTURING CHANGES; THIRD PARTY MANUFACTURING CIMA
agrees that no changes will be made to any materials, equipment or methods of
production or testing which are specified in the Specifications or any
Regulatory Approval by any Agency for Product without ESI's prior written
approval, which approval shall not be unreasonably withheld. Under no
circumstances will CIMA contract out all or any part of the manufacturing of
Product to a Third Party without prior written approval from ESI.

         2.15 PERMITTED SUBCONTRACTORS CIMA shall ensure that the permitted
contract manufacturers for the manufacture of Product have sufficient knowledge
and expertise to carry out the manufacture of Product and other subcontracted

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responsibilities. In addition CIMA shall ensure that (i) each such contract
manufacturer shall be in compliance with GMPs and shall be under the inspection
of all relevant Agencies and audited to be in compliance therewith, and (ii) ESI
will have the right to inspect and audit each such subcontractor's facilities
and records as provided in Section 2.11 hereof.

                                   ARTICLE III
                                ACTIVE INGREDIENT

         3.1 SUPPLY OF ACTIVE INGREDIENT

             (a) ESI agrees to supply CIMA, at no charge, all Active Ingredient
                 CIMA requires for the manufacture of Product under this
                 Agreement and CIMA agrees to use all and only, Active
                 Ingredient supplied by ESI exclusively in the manufacture of
                 Product.

             (b) As of the time of delivery to CIMA, all Active Ingredient will
                 conform to the Specifications.

             (c) CIMA shall procure all ingredients other than the Active
                 Ingredient used in the manufacture of Product, including
                 excipients, inactive ingredients, imprinting materials,
                 packaging and labeling materials unless otherwise mutually
                 agreed to by the parties.

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             (d) CIMA agrees to notify ESI in writing of its requirements for
                 Active Ingredient in a timely manner so as to assure the timely
                 filling of ESI's purchase orders for Product. In the event that
                 ESI fails to have supplied CIMA with sufficient quantities of
                 conforming Active Ingredient at least sixty days prior to the
                 due date for delivery of a Product order, CIMA will be relieved
                 of its obligation to timely fill ESI's purchase orders for such
                 Product to the extent prevented by ESI's failure to have Active
                 Ingredient timely delivered.

             (e) Upon receipt of Active Ingredient, CIMA shall promptly, and in
                 no event later than thirty (30) business days following
                 receipt, sample and analyze the same to assure that it complies
                 with the applicable Specifications. CIMA agrees to provide ESI
                 with the results of such analysis as soon as reasonably
                 possible, but in no event later than CIMA's manufacture of
                 Product containing such Active Ingredient, and to keep, true,
                 accurate and complete records of all such sampling and
                 analyses, which records shall at all reasonable times be
                 available for examination, audit and copying by ESI and its
                 representatives.

             (f) In the event that any Active Ingredient is determined by CIMA
                 not

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                 to be in compliance with applicable Specifications, CIMA shall
                 immediately notify ESI and shall follow all instructions of ESI
                 regarding, and be responsible for, re-analysis, sampling,
                 processing, return, disposal or destruction, including
                 certification of destruction, of such non-conforming Active
                 Ingredient.

             (g) If CIMA and ESI disagree as to whether any Active Ingredient
                 meets the applicable Specifications, the matter will be
                 submitted to an independent testing laboratory, acceptable to
                 both parties, for analysis, which analysis shall be performed
                 in compliance with applicable regulatory requirements. If the
                 Active Ingredient is determined to be non-conforming, ESI will
                 reimburse CIMA for CIMA's out-of-pocket expenses relating to
                 re-analysis, sampling, processing, returns, disposal and/or
                 destruction thereof.

         3.2 USE OF ACTIVE INGREDIENT

             (a) Title to all Active ingredient supplied to CIMA by ESI shall at
                 all times remain in ESI. CIMA shall clearly mark such Active
                 Ingredient as the property of ESI and keep such Active
                 Ingredient separate and apart from other raw materials.

             (b) CIMA shall not at any time sell or offer for sale, assign,
                 mortgage,
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                           pledge, or allow any lien to be created upon the
                           Active Ingredient provided by ESI or any portion
                           thereof.

                       (c) At the termination of this Agreement, CIMA shall
                           surrender to ESI all Active Ingredient in CIMA's
                           possession.

                       (d) CIMA shall be responsible for all loss or damage,
                           howsoever occasioned, in Active Ingredient at all
                           times it is in the possession of CIMA excepting only
                           reasonable loss necessarily inherent in the
                           manufacturing process. The parties agree that the
                           amount of Active Ingredient loss reasonable to the
                           Product's manufacturing process shall in no event be
                           more than six percent (6%) per batch or more than
                           four percent (4%) per any twelve month production
                           period. CIMA shall permit ESI, during normal business
                           hours and upon reasonable advance written notice,
                           access to all records necessary to determine and
                           verify Active Ingredient loss or damages. CIMA shall
                           reimburse ESI for all costs and expenses (including
                           shipping costs incurred by ESI in replacing Active
                           Ingredient lost or damaged but not Active Ingredient
                           which is determined by on analysis pursuant to
                           Paragraph 5.1(g) not to be in compliance with the
                           Specifications.

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                       (e) ESI shall not be liable for any damage, loss or
                           injury directly or indirectly resulting from the
                           storage or handling by CIMA of any Active Ingredient.

                                   ARTICLE IV
                              REGULATORY COMPLIANCE

         4.1 ADVERSE DRUG EXPERIENCES In order for the parties to comply with
their respective responsibilities under this Article IV and otherwise relating
to the reporting of Adverse Drug Experiences, to the extent either party
receives any information regarding Adverse Drug Experiences related to use of
Product, such party shall promptly provide the other party with such information
in accordance with the Adverse Event Reporting Procedures set forth in Exhibit B
hereto (as may be amended from time to time upon written agreement of the
parties).

         4.2 PRODUCT COMPLAINTS ESI shall be solely responsible for interacting
with the public with respect to customer complaints regarding Product quantity.
With respect to any such complaints, each party shall have the responsibility
for promptly conducting an investigation of any activities conducted by it under
this Agreement which may be relevant to the complaint. Each party shall inform
the other party of the nature, scope and details of any such complaint which
requires an investigation by the other party, and each party shall promptly
report the results of such investigation to the
<PAGE>   22

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

other party. Either party shall cooperate in any investigation by the other
party of each such complaint which involves the parties' duties under this
Agreement.

         4.3 COMPLIANCE ISSUES The parties acknowledge that the export of
technical data, materials or products is subject to the exporting party
receiving the necessary export licenses and that the parties cannot be
responsible for any delays attributable to export controls which are beyond the
reasonable control of either party. The parties agree that regardless of any
disclosure made by the party receiving an export of any ultimate destination of
any technical data, materials or products, the receiving party will not
re-export either directly or indirectly, any technical data, material or
products without first obtaining the applicable validated or general license
form the United States Department of Commerce.

                                    ARTICLE V
                               PAYMENT PROVISIONS

         5.1 INSPECTION OF RECORDS The parties shall maintain at their offices,
accurate and complete books and records consistent with sound business and
accounting practices and in such form and in such detail as to enable the amount
of payments payable under this Agreement by the respective party to be
determined. ESI and CIMA shall permit an independent certified accountant
(subject to obligations of confidentiality) appointed by the other party and
reasonably acceptable to ESI or

<PAGE>   23

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

CIMA(as applicable), at the other party's expense, to examine such books and
records at all reasonable times for the sole purpose of (i) verifying ESI's or
CIMA's (as applicable) reports and accounting submitted to the other party
hereunder and (ii) determining the correctness of payments. In the event of any
underpayment of any payment by at least five percent (5%), the costs of such
inspection shall be borne by the party who made such underpayment and such
underpayment shall be forthwith paid by such party to the other party with
interest at the rate specified in Section 5.3.

         5.2 PAYMENTS Each party shall make all payments due to the other party
hereunder by wire transfer in immediately available funds to an account
designated by the payee party.

         5.3 INTEREST The parties shall pay interest on any amounts overdue
under this Agreement at a rate equal to the U.S. dollar prime or equivalent rate
quoted by Citibank N.A. or another mutually acceptable bank, as in effect during
the period from the date due until payment.

                                   ARTICLE VI
                         REPRESENTATIONS AND WARRANTIES

         6. REPRESENTATION AND WARRANTIES OF EACH PARTY Each of CIMA and ESI
hereby represents, warrants and covenants to the other party hereto as follows:

<PAGE>   24

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

         (a) it is a corporation or entity duly organized and validly existing
under the laws of the state or other jurisdiction of incorporation or formation;

         (b) the execution, delivery and performance of this Agreement by such
party has been duly authorized by all requisite corporate action and does not
require any shareholder action or approval;

         (c) it has the power and authority to execute and deliver this
Agreement and to perform its obligations hereunder; and

         (d) the execution, delivery and performance by such party of this
Agreement and its compliance with the terms and provisions hereof does not and
will not conflict with or result in a breach of any of the terms and provisions
of or constitute a default under (ii) a loan agreement, guaranty, financing
agreement, agreement affecting a product or other agreement or instrument
binding or affecting it or its property (ii) the provisions of its charter or
operative documents or bylaws; or (iii) any order, writ, injunction or decree of
any court or governmental authority entered against it or by which any of its
property is bound.

         6.2 REPRESENTATIONS AND WARRANTIES OF CIMA In addition to the
representations and warranties made by CIMA under Section 6.1 above, CIMA hereby
further represents and warrants to ESI that:

<PAGE>   25

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

         (a) At the time of delivery of Product to the specified point of
delivery, Product shall (i) have been manufactured, stored and shipped in
accordance with GMPs, as applicable, and all other applicable laws, rules,
regulations or requirements in effect at the time of manufacture in the country
of manufacture (for example, in accordance with the procedures described in the
applicable Regulatory Approval); (ii) conform to the Specifications; (iii)) meet
the provisions of the Specifications; (iv) shall not be adulterated or
misbranded as provided for under any applicable law, order or regulation in
effect in the country of manufacture and the country in which Product is being
sold; (v) shall have been manufactured and have shelf-life in accordance with
[to be discussed]; and (vi) have been shipped in accordance with approved
procedures agreed between ESI and CIMA.

         (b) It shall have good and marketable title to all Product delivered to
ESI.

         6.3 NO INCONSISTENT AGREEMENTS Neither party has in effect and after
the Effective Date neither party shall enter into any oral or written agreement
or arrangement that would be inconsistent with its obligations under this
Agreement.

         6.4 REPRESENTATION BY LEGAL COUNSEL Each party hereto represents that
it has been represented by legal counsel in connection with this Agreement and
acknowledges that it has participated in the drafting hereof. In interpreting
and applying the terms and provisions of this Agreement, the parties agree that
no
<PAGE>   26

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

presumption shall exist or be implied against the party which drafted such terms
and provisions.

                              ARTICLE VII
                            INDEMNIFICATION

         7.1 INDEMNIFICATION BY ESI ESI shall indemnify, defend and hold
harmless CIMA and its Affiliates, and each of its and their respective
employees, officers, directors and agents (each a "CIMA Indemnified Party") from
and against any all liability, loss, damage, cost and expense (including
reasonable attorney's fees) (collectively, a "Liability") which the CIMA
Indemnified Party may incur, suffer or be required to pay resulting form or
arising in connection with (i) the breach by ESI of any representation or
warranty contained in this Agreement, or (ii) the manufacture, promotion,
distribution, use, testing, marketing, sale or other disposition of Product by
ESI, its Affiliates or sublicenses. Notwithstanding the foregoing, ESI shall
have no obligation under this Agreement to indemnify, defend or hold harmless
any CIMA Indemnified Party with respect to claims, demands, costs or judgments
which result from either (x) the failure of Product supplied by CIMA or its
Affiliates to comply with the Specifications or the applicable Regulatory
Approvals or (y) the willful misconduct or negligent acts or omissions of CIMA,
its Affiliates, or any of their respective employees, officers, directors or
agents.
<PAGE>   27

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

         7.2 INDEMNIFICATION BY CIMA CIMA shall indemnify, defend and hold
harmless ESI and its Affiliates, and each of its and their respective employees,
officers, directors and agents (each, an "ESI Indemnified Party") form and
against any Liability which the ESI Indemnified Party may incur, suffer or be
required to pay resulting from or arising in connection with the breach by CIMA
of any representation or warranty contained in this Agreement. Notwithstanding
the foregoing, CIMA shall have no obligation under this Agreement to indemnify,
defend, or hold harmless any ESI Indemnified Party with respect to claims,
demands, costs of judgments which result from the willful misconduct or
negligent acts or omissions of ESI, its Affiliates, or sublicensees or any of
their respective employees, officers, directors or agents.

         7.3 CONDITIONS TO INDEMNIFICATION The obligations of the indemnifying
party under Sections 7.1 and 7.2 are conditioned upon delivery of written notice
to the indemnifying party of any potential Liability promptly after the
indemnified party becomes aware of such potential Liability, provided, however,
that the failure to give such notice promptly shall not impair a party's rights
to indemnification under this Article VII unless the delay in providing such
notice has a material adverse effect on the ability of the indemnifying party to
defend against such Liability. The indemnifying party shall have the right to
assume the defense of any suit or claim related to the Liability if it has
assumed responsibility for the suit or claim in writing; however, if in the
<PAGE>   28

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

reasonable judgment of the indemnified party, such suit or claim involves an
issue or matter which could have a materially adverse effect on the business
operations or assets of the indemnified party, the indemnified party may waive
its rights to indemnity under this Agreement and control the defense or
settlement thereof, but in no event shall any such waiver be construed as a
waiver of any indemnification rights such party may have at law or in equity. If
the indemnifying party defends the suit or claim, the indemnified party may
participate in (but not control) the defense thereof at its sole cost and
expense.

         7.4 SETTLEMENTS Neither party may settle a claim of action related to a
Liability without the consent of the other party, if such settlement would
impose any monetary obligation on the other party or require the other party to
submit to an injunction or otherwise limit the other party's rights under this
Agreement. Any payment made by a party to settle any such claim or action shall
be at its own cost and expense except in the event that such payment was made
with the prior written consent of the indemnifying party, in which case such
payment will be subject to the indemnification obligations of the parties as set
forth in this Article VII.

         7.5 INSURANCE Each party further agrees to obtain and maintain, during
the term of this Agreement, Comprehensive General Liability Insurance, including
Products Liability Insurance, with reputable and financially secure insurance
carriers to cover its
<PAGE>   29

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

indemnification obligations under Section 7.1or 7.2, as applicable, or, in the
case of ESI, self-insurance, in each case with limits of not less than five
million dollars ($5,000,000.00) per occurrence and ten million dollars
($10,000,000.00) in the aggregate.

                                  ARTICLE VIII
                                CONFIDENTIALITY

         8.1 NONDISCLOSURE During the Term of this Agreement and for a period of
five (5) years thereafter, all proprietary and confidential business, technical,
scientific and/or regulatory information, including Technical Information,
disclosed to the receiving party or its Affiliates (herein collectively, the
(Receiving Party) by the other party or its Affiliates (herein collectively, the
(Disclosing Party) hereunder or under the existing Confidentiality Agreement
between the parties, which is marked as confidential at the time of disclosure,
or if disclosed or obtained orally or visually (or otherwise in a non-written
form), was described or summarized in a writing or other tangible form and
identified as confidential and forwarded to the Receiving Party within thirty
(30) days of such disclosure (collectively, Confidential Information), shall be
deemed to be confidential and shall be treated as such by the Receiving Party
and shall not be disclosed, in whole or in part, by the Receiving Party to any
other Person except as expressly set forth herein, and shall be used only for
the purposes of this
<PAGE>   30

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

Agreement. Notwithstanding the foregoing these mutual obligations of
confidentiality shall not apply to any information to the extent that such
information is:

         (i) independently developed by such party as documented by prior
written records outside the scope and not in violation of this Agreement;

         (ii) legally in the public domain at the time of its receipt or
thereafter legally becomes part of the public domain through no fault of the
recipient;

         (iii) received without an obligation of confidentiality from a Third
Party having the right to disclose such information;

         (iv) released from the restrictions of this Article VIII by the express
written consent of the Disclosing Party;

         (v) as may be required for securing Regulatory Approval, or as may be
required to be disclosed to an Agency or as otherwise required by a court order
or any law or regulation (including, as may be required in connection with any
filings made with the Securities and Exchange Commission or by the disclosure
policies of a major stock exchange in the Territory); provided, however, that at
the other party's request, the disclosing party shall request that the relevant
legal or regulatory authority, or major stock exchange, treat as confidential
any Confidential Information of either party included in any such disclosure and
generally use diligent efforts to seek confidential treatment where available.
<PAGE>   31

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

         8.2 SCOPE OF CONFIDENTIALITY

         CIMA and ESI agree to limit the disclosure of any Technical Information
and other Confidential Information received hereunder to such Affiliates,
employees, consultants and distributors as are necessary to carry out the
provisions of this Agreement and who are likewise bound by provisions equivalent
to this Article VIII, except that, ESI may disclose Confidential Information to
actual or potential sublicenses and subdistributors, provided that they are
likewise bound by confidentiality provisions similar to, or more stringent than,
those set forth in this Article VIII. The parties shall take reasonable measures
to assure that no unauthorized use or disclosure is made by Persons to whom
access to such Confidential Information is granted.

                                   ARTICLE IX
                              TERM AND TERMINATION

         9.1 TERM This Agreement shall be effective as of the Effective Date,
and, unless sooner terminated by mutual agreement or pursuant to any other
provision of this Agreement, shall continue in full force and effect in each
country of the Territory for a period of ten (10) years after the Launch Date of
Product in the first Major Country of the Territory which shall be deemed to
occur no later than six (6) months after obtaining
<PAGE>   32

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

Regulatory Approval or where applicable, Pricing Approval, in the first Major
Country of the Territory (the Initial Term). After the Initial Term, this
Agreement shall be automatically renewed for successive two (2) year periods
(each, an Extended Term), unless ESI notifies CIMA of ESI's intent not to renew
this Agreement at least nine (9) months prior to the expiration of the Initial
Term or the then current Extended Term. The Term shall include the Initial Tem
and any Extended Term. If the Development and License Agreement is terminated
for any reason other than expiration, then this Agreement shall automatically
terminate.

         9.2 TERMINATION FOR DEFAULT Each party may terminate this Agreement as
a whole if the other party commits a material breach of any material obligation
under this Agreement and fails to remedy such breach within sixty (60) days (or,
in the case of a late payment, ten (10) business days of notice of such breach,
or other longer period of time if mutually agreed.

         9.3 TERMINATION BY ESI ESI shall have the right, in its sole
discretion, to terminate this Agreement at any time during the Term of this
Agreement upon six (6) months' prior written notice to CIMA.

         9.4 NO DAMAGES UPON EXPIRATION OR TERMINATION Except as otherwise set
forth in this Agreement, neither party shall be entitled to any compensation
whatsoever
<PAGE>   33

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

as a result of expiration or termination of this Agreement, but without limiting
either party's damages for any breach of this Agreement.

         9.5 CONTINUING OBLIGATIONS Termination or expiration of this Agreement
for any reason shall be without prejudice to any obligations which shall have
accrued to the benefit of either party prior to such termination or expiration.
Upon termination or expiration of this Agreement, any payments owed to the other
party on or before the effective date of termination would be due within thirty
(30) days of the effective date of such termination or expiration. The following
provisions of this Agreement shall survive expiration or termination hereof:
Articles VIII, IX, and XI.

                                    ARTICLE X
                                  PUBLICATIONS

         10.1 PUBLICATIONS The parties shall mutually agree upon publications
and the publication strategy with respect to work undertaken by the parties
relating to Product, and neither party shall publish any result or study
generated or developed under this Agreement except upon review by the other
party at least sixty (60) days prior to submission of an abstract or manuscript
for publication.
<PAGE>   34

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

                                   ARTICLE XI
                                  MISCELLANEOUS

         11.1 FORCE MAJEURE Neither party shall be liable for delay or failure
to perform its obligations hereunder for so long as that failure or delay is the
result of an event beyond its control which it could not have avoided by the
exercise of reasonable diligence, (a force majeure event), provided that such
party uses Commercially Reasonable Efforts to comply with the terms of this
Agreement as soon as practicable. A party asserting a force majeure event shall
notify the other party promptly, giving an indication of the likely extent and
duration thereof.

         11.2 ASSIGNMENT; SUCCESSORS AND ASSIGNS Neither party shall at any
time, without obtaining the prior written consent of the other party, assign or
transfer this Agreement to any Person. Notwithstanding the foregoing, each party
shall be permitted to assign this Agreement to its Affiliates or to perform this
Agreement, in whole or in part, through its Affiliates, provided that such party
shall be primarily liable and responsible for performance by such Affiliate
hereunder; and each party may also assign this Agreement to any successor by
merger or upon a sale of all or substantially all of its assets. This Agreement
shall be binding upon and shall inure to the benefit of the parties and their
successors and permitted assigns.
<PAGE>   35

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

         11.3 NOTICES Any notices required or permitted to be given hereunder
shall be in writing in the English language and shall be delivered by
international courier service (requiring signature upon receipt) or sent by
first class air mail, postage prepaid, or telefax (confirmed by phone
conversation with the recipient) to the addresses set forth below. The parties
may change the address at which notice is to be given by giving notice to the
other party as herein provided. All notices shall be deemed effective upon
receipt by the party to whom it is addressed.

If to CIMA:       CIMA, Labs. Inc.
                  10000 Valley View Road
                  Eden Prairie, MN  55344
                  Attention:  Dr. John Siebert
                              President and CEO
                  Telephone: (612) 947-8762
                  Telefax:   (612) 947-8770
<PAGE>   36

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

If to ESI:                               With a copy to:
ESI Lederle                              American Home Products Corporation
130 North Radnor-Chester Road            5 Giralda Farms
St. Davids, Pennsylvania 19087           Madison, New Jersey 07940

Attention:  President                    Attention:
Telephone: (610) 971-4550                Senior Vice President & General Counsel
Telefax:  (610) 995-3394                 Telephone: (973) 660-6040
                                         Telefax: (973) 660-7050

         11.4 GOVERNING LAW AND JURISDICTION This Agreement and its execution,
validity and interpretation shall be governed in all respects in accordance with
the laws of the State of New York, excluding conflicts of law rules.

         11.5 SEVERABILITY In the event that any provision of this Agreement
shall be held to be unenforceable, invalid or in contravention of applicable
law, such provision shall be of no effect, and the parties shall negotiate in
good faith to replace such provision with a provision which effects to the
extent possible the original intent of such provision.

         11.6 COMPLETE AGREEMENT; MODIFICATIONS This Agreement, together with
the Development and License Agreement and all Exhibits attached to each,
constitutes the entire Agreement between the parties with respect to the present
subject matter, all prior negotiations, agreements and understandings being
expressly canceled hereby. This Agreement may be amended only by a written
agreement embodying the full terms of the amendment signed by authorized
representatives of both parties.
<PAGE>   37

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(B)(4)
                                                            200.83 AND 204.24B-2

         11.7 NO AGENCY Neither party shall by virtue of this Agreement have any
power to bind the other to any obligation nor shall this Agreement create any
relationship of agency, partnership or joint venture.

         11.8 NO WAIVER No term or condition of this Agreement shall be
considered waived unless reduced to writing and duly executed by an officer of
the waiving party. Any waiver by any party of a breach of any term or condition
of this Agreement will not be considered as a waiver of any subsequent breach of
this Agreement, of that term or condition or any other term or condition hereof.

         11.9 COUNTERPARTS This Agreement may be executed in counterparts, each
of which together shall constitute one and the same Agreement.

         IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first above written.

CIMA LABS INC.                             ESI LEDERLE

By: /s/ John M. Siebert                    By: /s/ Mike Dey
Name: John M Siebert                       Name: Mike Dey
Title: President and CEO                   Title: President<PAGE>   1
                                                                 EXHIBIT 10.1(c)

                              LENDER CONSENT LETTER

                      CHARTER COMMUNICATIONS OPERATING, LLC
                   CREDIT AGREEMENT DATED AS OF MARCH 18, 1999
                                 THIRD AMENDMENT

To:      The Chase Manhattan Bank, as Administrative Agent
         270 Park Avenue
         New York, New York 10017

         Bank of America, N.A., as Administrative Agent
         901 Main Street
         Dallas, Texas 75202

Ladies and Gentlemen:

                  Reference is made to the CREDIT AGREEMENT, dated as of March
18, 1999, as amended by the First Amendment dated as of June 28, 1999 and the
Second Amendment dated as of December 14, 1999 (the "Credit Agreement"), among
CHARTER COMMUNICATIONS OPERATING, LLC (the "Borrower"), CHARTER COMMUNICATIONS
HOLDINGS LLC, the Lenders parties to the Credit Agreement, the Documentation
Agents and Syndication Agents named therein and THE CHASE MANHATTAN BANK and
BANK OF AMERICA, N.A., as Administrative Agents (in such capacity, the
"Administrative Agents").

                  The Borrower has requested amendments to the Credit Agreement
on the terms described in the Third Amendment to the Credit Agreement in the
form attached hereto as Exhibit A (the "Third Amendment").

                  Pursuant to Section 10.1 of the Credit Agreement, the
undersigned Lender hereby consents to the execution by the Administrative Agents
of the Third Amendment.

                              Very truly yours,

                              --------------------------------------------------
                              (NAME OF LENDER)

                              By
                                ------------------------------------------------
                                Name:
                                Title:

Dated as of February 24, 2000

<PAGE>   2

                                                                       EXHIBIT A

                  THIRD AMENDMENT, dated as of February 24, 2000 (this "Third
Amendment"), to the CREDIT AGREEMENT, dated as of March 18, 1999, as amended by
the First Amendment dated as of June 28, 1999 and the Second Amendment dated as
of December 14, 1999 (the "Credit Agreement"), among CHARTER COMMUNICATIONS
OPERATING, LLC (the "Borrower"), CHARTER COMMUNICATIONS HOLDINGS LLC, the
Lenders parties to the Credit Agreement, the Documentation Agents and
Syndication Agents named therein and THE CHASE MANHATTAN BANK and BANK OF
AMERICA, N.A., as Administrative Agents (in such capacity, the "Administrative
Agents"). Terms defined in the Credit Agreement shall be used in this Third
Amendment with their defined meanings unless otherwise defined herein.

                              W I T N E S S E T H :

                  WHEREAS, the Borrower wishes to amend the Credit Agreement in
the manner set forth herein; and

                  WHEREAS, each of the parties hereto is willing to enter into
this Third Amendment on the terms and subject to the conditions set forth
herein;

                  NOW, THEREFORE, in consideration of the premises and for other
good and valuable consideration the receipt and sufficiency of which is hereby
acknowledged, the parties hereto hereby agree as follows:

         SECTION I.        AMENDMENTS TO CREDIT AGREEMENT.

                  1. Section 1.1. Section 1.1 of the Credit Agreement is hereby
amended by adding the following new definitions in the appropriate alphabetical
order:

                  "Qualified Indebtedness": (a) with respect to a Qualified
         Parent Company, any Indebtedness (i) which is issued in a Rule 144A
         private placement or registered public offering, (ii) which is not held
         by any member of the Charter Group and (iii) as to which 100% of the
         Net Cash Proceeds thereof are used by such Qualified Parent Company to
         make Investments in one or more of its Subsidiaries engaged
         substantially in businesses of the type described in Section 7.14(a)
         and/or to refinance other Qualified Indebtedness or Indebtedness of the
         Borrower and (b) with respect to an Affiliate of the Borrower, any
         Indebtedness as to which 100% of the Net Cash Proceeds thereof were
         contributed to the Borrower.

                  "Qualified Parent Company": Charter Communications Holding
         Company, LLC or any of its direct or indirect Subsidiaries, in each
         case provided that the Borrower shall be a direct or indirect
         Subsidiary of such Person.

                  2. Section 2.1(c). Section 2.1(c) of the Credit Agreement is
hereby amended by changing the amount "$500,000,000" contained in clause (iv)(w)
of the penultimate sentence thereof to the amount "$1,000,000,000".

                  3. Section 7.1(a). Section 7.1(a) of the Credit Agreement is
hereby amended and restated in its entirety as follows:

                           (a) Consolidated Leverage Ratio. Permit the
         Consolidated Leverage Ratio determined as of the last day of any fiscal
         quarter of the Borrower ending during any period set forth below to
         exceed the ratio set forth below opposite such period:

<PAGE>   3

<TABLE>
<CAPTION>
                         Period                     Consolidated Leverage Ratio
                         ------                     ---------------------------
<S>               <C>                               <C>
                  04/01/99 - 12/31/01                       5.00 to 1.0
                  01/01/02 - 12/31/02                       4.50 to 1.0
                  01/01/03 - 06/30/03                       4.25 to 1.0
                  07/01/03 and thereafter                   4.00 to 1.0"
</TABLE>
                  4. Section 7.6(b). Section 7.6(b) of the Credit Agreement is
hereby amended and restated in its entirety as follows:

                  "(b) the Borrower may make distributions (directly or
         indirectly) to any Qualified Parent Company or any Affiliate of the
         Borrower for the purpose of enabling such Person to make scheduled
         interest payments in respect of its Qualified Indebtedness, provided
         that (i) no Default or Event of Default shall have occurred and be
         continuing or would result therefrom, (ii) each such distribution shall
         be made on a Threshold Transaction Date (except in the case of any
         distribution made for the purpose of paying interest on (x) Qualified
         Indebtedness as to which 100% of the Net Cash Proceeds thereof were
         contributed to the Borrower as a capital contribution, (y) Qualified
         Indebtedness incurred to refinance such Qualified Indebtedness or
         (z) the Senior Notes or any Indebtedness incurred to refinance the
         Senior Notes) and (iii) each such distribution shall be made no earlier
         than three Business Days prior to the date the relevant interest
         payment is due;"

                  5. Section 7.6(c). Clause (i) of Section 7.6(c) of the Credit
Agreement is hereby amended and restated in its entirety as follows:

         "(i) the Borrower may make distributions to Charter Holdings to be used
         to repurchase, redeem or otherwise acquire or retire for value any
         Equity Interests of Charter Holdings or Charter Communications Inc.
         held by any member of management of Charter Holdings, the Borrower or
         any of its Subsidiaries pursuant to any management equity subscription
         agreement or stock option agreement in effect as of the Stage One
         Closing Date, provided that the aggregate amount of such distributions
         shall not exceed $10,000,000 in any fiscal year of the Borrower"

         SECTION II.       MISCELLANEOUS.

                  1. No Change. Except as expressly provided herein, no term or
provision of the Credit Agreement shall be amended, modified or supplemented,
and each term and provision of the Credit Agreement shall remain in full force
and effect.

                  2. Effectiveness. This Third Amendment shall become effective
as of the date hereof upon receipt by the Administrative Agents of
(a) counterparts hereof duly executed by Holdings and the Borrower and
(b) consent letters authorizing the Administrative Agents to enter into this
Third Amendment from the Required Lenders.

                  3. Counterparts. This Third Amendment may be executed by the
parties hereto in any number of separate counterparts, and all of said
counterparts taken together shall be deemed to constitute one and the same
instrument.

                  4. Governing Law. THIS THIRD AMENDMENT AND THE RIGHTS AND
OBLIGATIONS OF THE PARTIES UNDER THIS THIRD AMENDMENT SHALL BE GOVERNED BY, AND
CONSTRUED AND INTERPRETED IN ACCORDANCE WITH, THE LAW OF THE STATE OF NEW YORK.
                  IN WITNESS WHEREOF, the parties hereto have caused this Third
Amendment to be duly executed and delivered as of the day and year first above
written.

<PAGE>   4
                                                                               3

                                 CHARTER COMMUNICATIONS HOLDINGS LLC

                                 By:
                                    -------------------------------------------
                                    Name: Eloise A. Engman
                                    Title: Vice President

                                 CHARTER COMMUNICATIONS OPERATING, LLC

                                 By:
                                    -------------------------------------------
                                    Name: Eloise A. Engman
                                    Title: Vice President

                                 THE CHASE MANHATTAN BANK,
                                    as an Administrative Agent

                                 By:
                                    -------------------------------------------
                                    Name:
                                    Title:

                                 BANK OF AMERICA, N.A., as an Administrative
                                 Agent

                                 By:
                                    -------------------------------------------
                                    Name:
                                    Title:

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00005-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00005-of-00352.parquet"}]]