Document:

Exhibit 10.4

L  E
A  S  E   A  G  R  E  E  M
E  N  T

BY AND BETWEEN:

EASTPARK AT 8A

“Landlord”

- and -

LINGUAGEN CORP.

“Tenant”

	
  PREMISES:

  	
  2005 Eastpark Boulevard

  
	
   

  	
  Cranbury, New Jersey 08512

  

 

DATED:    December 9, 2002

AGREEMENT, made December 9, 2002, between Eastpark at
8A, a general partnership, 1000 Eastpark Boulevard, Cranbury, New Jersey 08512,
“Landlord”; and Linguagen, Corp., 215 College Road, Paramus, New Jersey 07652, “Tenant”.

W  I  T
N  E  S  S  E  T  H  :

WHEREAS, the Landlord intends to lease to the Tenant
the suite at 2005 Eastpark Boulevard, Cranbury, New Jersey 08512 (“Building”),
constituting a portion of the office/industrial park known as Eastpark at 8A (“Office
Park”); and

WHEREAS, the parties hereto wish to mutually define
their rights, duties, and obligations in connection with the Lease.

NOW,
THEREFORE, in consideration of the promises set forth herein, the Landlord
leases unto the Tenant and the Tenant rents from the Landlord the leased
premises described in Paragraph 1, and the Landlord and Tenant do hereby
mutually covenant and agree as follows:

1.                         LEASED PREMISES

The
leased premises shall consist of 5,100 rentable square feet of office and
laboratory space (“Leased Premises”) as measured from outside of exterior walls
to center line of common walls, together with all existing improvements, and
all easements, tenements, appurtenances, hereditaments, rights and privileges
appurtenant thereto, and any and all fixtures and equipment which have been
installed in the Building by the Landlord for the use of the Tenant in its
occupancy of the Leased Premises. Tenant shall also have the right to use all
common areas of the Office Park in a similar manner as other Office Park
tenants. Tenant shall have the right of 24 hours per day, 365 days per year
access to the Leased Premises, Office Park, and parking areas.

2.                         TERM OF LEASE

The
term of the Lease shall be five years, to commence on the later of (a) December
1, 2002, and (b) the issuance of
a C.C.O. (“Commencement Date”), and to end on the last day of the month in
which occurs the fifth (5th) anniversary of
the Commencement Date.

Initial: Landlord

Tenant

Lease Version Date: 11-22-02

3.                         TENANT IMPROVEMENTS

3.1   The
Tenant shall accept the Leased Premises in its existing condition, subject to
Landlord painting the interior walls and replacing the carpet with new
commercial grade carpeting in a complementary color to the walls.

3.2   To
the extent installed by Tenant, Tenant shall be responsible for the design and
installation of its own phone, data, communication, fire alarm, and security
systems.

3.3   All
mechanical units and equipment provided as a part of the Leased Premises shall
be in operating condition at the Commencement Date.

4.                         RENT

4.1   Tenant
shall pay, as rent for the Leased Premises, an annual base rent per square foot
of $32.00, for an aggregate annual base rent of $163,200.00 (“Base Rent”),
payable monthly in the sum of $13,600.00. The annual Base Rent shall be payable
in advance in equal monthly installments on the first day of each calendar
month.

4.2   Tenant
shall pay the following, which shall be referred to herein as “Additional Rent”;

(a)                          A fee per square foot for the Common Area
Expenses (as hereafter defined) and real estate taxes; and

(b)                         Any other charges as provided in this Lease.
The Base Rent and Additional Rent shall be referred to hereafter as “Rent.”

4.3   Tenant
covenants to pay the Rent in lawful money of the United States which shall be
legal tender for the payment of all debts, public and private, at the time of
payment. Such Rent shall be paid to Landlord at its office address hereinabove
set forth, or at such other place as Landlord may, from time to time, designate
by notice to Tenant.

4.4   The
Rent shall be payable by Tenant without any set-off or deduction of any kind or
nature whatsoever and without notice or demand. The sum of all increases
required to be paid as Additional Rent or Base Rent in accordance with this
Lease, shall be paid to Landlord within ten (10) days following the giving of
notice hereof by Landlord of such increases.

 2
 

5.                         PARKING
AND USE OF EXTERIOR AREA

The
Tenant shall have the right to use parking spaces on a non-exclusive basis in
common with other tenants of the Building. Landlord reserves the right to allocate
specific parking spaces if it chooses, but at all times Tenant shall have
reasonably sufficient parking available for its use. The Landlord and Tenant
mutually agree that they will not block, hinder or otherwise obstruct the
access driveways and parking areas so as to impede the free flow of vehicular
traffic on the property. In connection with the use of the loading platforms,
if any, Tenant agrees that it will not use the same so as to unreasonably
interfere with the use of the access driveways and parking areas. Tenant shall
not store trailers or other vehicles on any portion of the access driveways or
parking areas, and may not utilize any portion of the land or Building outside
of the Leased Premises for any purpose unless consented to in advance by
Landlord.

6.                         USE

The
Tenant covenants and agrees to use and occupy the Leased Premises only as an
office and laboratory, which use is expressly subject to all applicable zoning
ordinances, rules and regulations of any governmental instrumentalities, boards
or bureaus having jurisdiction thereof. Tenant’s use of the Leased Premises
shall not interfere with the peaceable and quiet use and enjoyment by other
tenants at their respective leased premises located at the Building or in the
Office Park, nor shall Tenant’s activities cause Landlord to be in default
under its leases with such other tenants.

7.                         REPAIRS
AND MAINTENANCE

7.1   Tenant
shall generally maintain and repair the Leased Premises, in a good and
workmanlike manner, and shall, at the expiration of the term, deliver the
Leased Premises in good order and condition, damages by fire or casualty, the
elements and ordinary wear and tear excepted. Tenant covenants and agrees that
it shall not cause or permit any waste, damage or disfigurement to the Leased
Premises, or any overloading of the floors. Tenant shall maintain and make all
repairs to the floor surface, plumbing and electrical systems (including all
ballasts and fluorescent fixtures) and the entire HVAC system located within
the Leased Premises. Landlord shall be responsible for repairs necessary to the
roof, exterior and load-bearing walls, and electric and plumbing systems to the
point where they enter the Leased Premises, unless repair is necessitated by
any act of Tenant, or

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its agents, employees or
contractors. If, however, any repair or maintenance is required due to the acts
or omissions of Landlord, its agents, contractors or employees, Landlord will
promptly repair the damage, the cost of such repair to be at Landlord’s
expense. Landlord will maintain and repair all other portions of the Office
Park of which the Building is a part in a proper operating and reasonably safe
condition.

7.2   The
Tenant shall, at its own cost and expense, pay all metered utility and service
charges, including gas and electric servicing the Leased Premises. Landlord
shall have the option to install, at its own cost, a separate water meter and
invoice Tenant directly for its water usage. The Tenant agrees to maintain all
leased areas at a minimum temperature of 45 degrees, excluding cold rooms or
other rooms specifically designed for a lower temperature, to prevent the
freezing of domestic water and sprinkler pipes. Tenant shall not store any
items outside the Leased Premises, and shall deliver its garbage and recyclables
to the central receiving area on the lot. Tenant shall dispose of all
hazardous/medical waste with an approved hauler at its own cost.

7.3   Landlord
shall provide the following during the term of this Lease:

(a)                          Cooperate with all utility companies providing
water, gas and electrical service to the point where they enter the Leased
Premises for Tenant’s permitted uses;

(b)                         Extermination and pest control when necessary;

(c)                          24-hour access to the Leased Premises;

(d)                         Maintain the fire sprinkler system; and

(e)                          Maintain the common areas of the Office Park,
in a manner similar to other office parks in the area, with the cost to be
passed on to Tenant as set forth in Paragraph 8.

7.4   Landlord
does not warrant that any services Landlord or any public utilities supply will
not be interrupted. Services may be interrupted because of accidents, repairs,
alterations, improvements or any other reasons beyond the reasonable control of
Landlord. If, however, in the event of an interruption of service or supply
which is either within or outside of Landlord’s control, Tenant is unable to
conduct its business in the Leased Premises for a period of thirty (30) days,
or a total of sixty (60) days in a ninety (90) day period, then the rent
payable hereunder shall abate until such condition is remedied.

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8.                         COMMON AREA EXPENSES, TAXES AND INSURANCE

8.1   The
Tenant shall pay to the Landlord, monthly, as Additional Rent an amount equal
to Tenant’s proportionate share of the cost of the following items (“Common
Area Expenses”). The cost for capital improvements to the Building or Office
Park shall not be included in Common Area Expenses. Tenant’s share of the
Common Area Expenses shall be known as its “Proportionate Share.”

(a)                          The costs incurred by the Landlord for real
estate taxes and the operation, maintenance or repair of the following items in
the Office Park;

	
  (1)

  	
  lawns and landscaping;

  
	
   

  	
   

  
	
  (2)

  	
  water and standby sprinkler charges;

  
	
   

  	
   

  
	
  (3)

  	
  exterior lighting;

  
	
   

  	
   

  
	
  (4)

  	
  exterior sewer lines;

  
	
   

  	
   

  
	
  (5)

  	
  exterior utility lines;

  
	
   

  	
   

  
	
  (6)

  	
  repair and maintenance of any signs serving the
  Office Park;

  
	
   

  	
   

  
	
  (7)

  	
  snow removal;

  
	
   

  	
   

  
	
  (8)

  	
  normal garbage disposal and recycling;

  
	
   

  	
   

  
	
  (9)

  	
  general ground maintenance;

  
	
   

  	
   

  
	
  (10)

  	
  parking lot, driveways and walkways;

  
	
   

  	
   

  
	
  (11)

  	
  maintenance contracts for the roof;

  
	
   

  	
   

  
	
  (12)

  	
  pest control;

  
	
   

  	
   

  
	
  (13)

  	
  central station monitoring for fire sprinkler
  system; and

  
	
   

  	
   

  
	
  (14)

  	
  other ordinary maintenance expenses normally
  incurred by Landlord relating to the Building and common areas of the Office
  Park;

  

 

(b)                         The cost of the annual insurance premiums
charged to the Landlord for insurance coverage which insure the buildings in
the Office Park. The insurance shall be for the full replacement value of all
insurable improvements with any customary extensions of coverage including, but
not limited to, vandalism, malicious mischief, sprinkler damage and
comprehensive liability, and insurance for one year’s rent. The Landlord shall
maintain said insurance in effect at all times hereunder. Any increase in the
insurance premiums due to a change in rating of the Building

 5
 

which is solely attributable to Tenant’s use, or due
to special Tenant equipment, shall be paid entirely by the Tenant. Tenant
expressly acknowledges that Landlord shall not maintain insurance on Tenant’s
furniture, fixtures, machinery, inventory, equipment or other personal
property. Tenant shall at all times, at its own cost and expense, carry
sufficient “All Risk” property insurance on a replacement cost basis to avoid
any coinsurance penalties in applicable policies on all of Tenant’s furniture,
furnishings, fixtures, machinery, equipment and installations as well as on any
alterations or improvements made to the Leased Premises by Tenant at its own
cost and expense subsequent to the Commencement Date. Such coverage is to
include property undergoing additions and alterations, and shall cover the
value of equipment and supplies awaiting installations. On an annual basis,
Tenant shall furnish Landlord with certificates of the existence of such
insurance; and

(c)                          The real estate and personal property taxes
assessed against the Office Park for land, building and improvements, along
with any levy for the installation of local improvements affecting the Office
Park assessed by any governmental body having jurisdiction thereof. The real
estate tax obligation of the Tenant shall include any tax or imposition for
parking log usage that may be levied by any governmental body having
jurisdiction thereof. In addition to its Proportionate Share of the above
items, Tenant shall pay directly all real estate taxes assessed by the
municipality on its Tenant improvements; and

(d)                         A management fee of three (3%) percent of the
Tenant’s Base Rent.

8.2   Tenant’s
Share of Common Area Expenses for any calendar year, part of which falls within
the term of this Lease and part of which does not, shall be appropriately
prorated. Tenant shall not be obligated to pay any part of (1) any taxes on the
income of the Landlord or the holder of an underlying mortgage and any taxes on
the income of the lessor under any underlying lease, (2) any corporation,
unincorporated business or franchise taxes, (3) any estate gift, succession or
inheritance taxes, (4) any capital gains, mortgage recording or transfer taxes,
(5) any taxes or assessments attributable to any sign attached to, or located
on, the Building or the land, or (6) any similar taxes imposed on the Landlord,
the holder of any underlying mortgage or the lessor under any underlying lease.

8.3   During
the first year of the lease term, the Tenant shall pay $3.00 per square foot as
its Proportionate Share. For each subsequent calendar year of the Term,
Landlord shall

 6
 

provided Tenant with Landlord’s estimate of the Tenant’s
Proportionate Share by February 28th. Within ninety (90) days of the expiration
of each calendar year of the Term, the Landlord shall furnish to Tenant a
detailed breakdown of the actual Common Area Expenses. Tenant shall have the
right, within sixty (60) days of receipt of the breakdown, and during normal
business hours, to examine Landlord’s books and records with respect to the
Common Area Expenses. In the event Tenant’s Proportionate Share shall be
greater than the aggregate paid by the Tenant during the prior period, Tenant
shall pay any difference, in one lump sum within thirty (30) days after demand.
In the event Tenant shall have overpaid its Proportionate Share, any such
overage shall be applied to the Common Area Expenses prospectively due under
the Lease. This procedure shall be followed during each year of the lease term,
and at the expiration of the Lease, any overage or underage shall be credited
or paid after computation by the Landlord, which obligation of Landlord and
Tenant shall survive the expiration of the lease term.

8.4   If
at any time during the term of this lease the method or scope of taxation
prevailing at the commencement of the lease term shall be altered, such
substituted tax or imposition shall be payable and discharged by the Tenant in
the manner required pursuant to the law which shall authorize such change.

8.5   The
Tenant covenants and agrees that it will, at its sole cost and expense, carry
liability insurance covering the Leased Premises in the minimum amount of
$1,000,000.00 per accident for one (1) person, $3,000,000.00 per accident for
two (2) or more persons, and a minimum amount of $300,000.00 for properly
damage. The Tenant shall add the Landlord as an additional insured on such
policy and will furnish Landlord with a certificate of said liability insurance
prior to the Commencement Date and annually thereafter. The certificate shall
contain a clause that the policy will not be canceled except on ten (10) days
written notice to the Landlord.

8.6   The
parties covenant and agree that the insurance policies required to be furnished
in accordance with the terms and conditions of this Lease, or in connection
with insurance policies which they obtain insuring such insurable interest as
Landlord or Tenant may have in its own properties, whether personal or real,
shall expressly waive any right of subrogation on the part of the insurer
against the Landlord or Tenant. Landlord and Tenant each waives all right of
recovery

 7
 

against the other, its agents or employees for any loss, damage or
injury of any nature whatsoever to property or person for which the waiving
party is required by this Lease to carry insurance.

9.                         SIGNS

Landlord
will provide a monument sign listing all of the tenants in the Office Park. At
its sole expense, the Tenant shall have the right to install on the entrance
door to the Leased Premises, only such signs as are required by Tenant for the
purpose of identifying the Tenant.

10.                   ASSIGNMENT AND SUBLETTING

10.1   The
Tenant may not assign or sublet the Leased Premises without Landlord’s consent,
which shall not be unreasonably withheld. Tenant shall advise the Landlord in
writing, by certified mail, return receipt requested of its desire to assign or
sublease and Landlord shall have forty-five (45) days from receipt of such
notice to notify Tenant whether it rejects or consents to the assignment or
sublease, or elects to re-capture pursuant to the following. Landlord shall
also have the option to elect to re-capture the Leased Premises and terminate
the Lease. If Landlord elects to recapture the Leased Premises, Tenant shall
surrender the Leased Premises no later than ninety (90) days after Landlord’s
written notice of its election to recapture.

10.2   The
Landlord’s consent shall not be required and the terms and conditions of
Paragraph 10.1 shall not apply as to Landlord’s right to recapture if the
Tenant assigns or subleases the Leased Premises to a parent, subsidiary,
affiliate or a company into which Tenant is merged or with which Tenant is
consolidated, or to the purchaser of all or substantially all of the assets of
Tenant.

10.3   In
connection with any permitted assignment or subletting, (i) the Tenant shall
pay monthly to the Landlord fifty (50%) percent of any increment in rent
received by Tenant per square foot over the rent then in effect during the year
of the assignment or subletting, which payment shall be made monthly together
with the required rent hereunder; and (ii) if Tenant receives any consideration
or value for such assignment or subletting, Landlord shall be paid fifty (50%)
percent of any such consideration or value within ten (10) days after receipt
of the same by Tenant. As a condition hereunder, Tenant warrants and represents
to Landlord that it will furnish to Landlord a copy of all pertinent documents
with respect to any such assignment or subletting so as to establish Tenant’s
obligation to Landlord hereunder.

 8
 

10.4   In
the event of any assignment or subletting permitted by the Landlord, the Tenant
shall remain and be directly and primarily responsible for payment and
performance of the within Lease obligations, and the Landlord reserves the
right, at all times, to require and demand that the Tenant pay and perform the
terms and conditions of this Lease. In the case of a complete recapture, Tenant
shall be released from all further liability with respect to the recaptured
space. No such assignment or subletting shall be made to any Tenant who shall
occupy the Leased Premises for any use other than that which is permitted to
the Tenant, or for any use which may be deemed inappropriate for the Building
or extra hazardous, or which would in any way violate applicable laws,
ordinances or rules and regulations of governmental boards and bodies having
jurisdiction.

11.                   FIRE
AND CASUALTY

11.1   In
case of any damage to or destruction of any portion of the building of which
the Leased Premises is a part by fire or other casualty occurring during the
term of this Lease (or previous thereto), which shall render at least one-third
(1/3rd) of the floor area of the Leased Premises or
the building untenantable or unfit for occupancy, which damage cannot be
repaired within one hundred eighty (180) days from the happening of such
casualty, using reasonable diligence (“Total Destruction”) then the term hereby
created shall, at the option of the Landlord, upon written notice to the Tenant
within fifteen (15) days of such fire or casualty, cease and become null and
void from the date of such Total Destruction. In such event the Tenant shall
immediately surrender the Leased Premises to the Landlord and this Lease shall
terminate. The Tenant shall only pay rent to the time of such Total
Destruction. However, in the event of Total Destruction if the Landlord shall
elect not to cancel this Lease within the 15-day period, the Landlord shall
repair and restore the same to substantially the same condition as it was prior
to the damage or destruction, with reasonable speed and dispatch. The rent
shall not be accrued after said damage or while the repairs and restorations
are being made, but shall recommence immediately after the premises are
restored as evidenced by the issuance of a CO/CA by municipal authorities. In
any case where Landlord must restore, consideration shall be given for delays
under the Force Majeure paragraph in this Lease. Whether or not this Lease has
been terminated as a result of a casualty, in every instance, all insurance
proceeds payable as a result of damage or destruction to the Building shall be
paid to Landlord as its sole and exclusive property.

 9
 

11.2   In
the event of any other casualty which shall not be tantamount to Total
Destruction the Landlord shall repair and restore the Building and the Leased
Premises to substantially the same condition as they were prior to the damage
or destruction, with reasonable speed and dispatch. The rent shall abate or
shall be equitably apportioned as to any portion of the Leased Premises which
shall be unfit for occupancy by the Tenant, or which cannot be used by the
Tenant to conduct its business. The rent shall recommence immediately upon
restoration of the Leased Premises as evidenced by the issuance of a CO/CA by
municipal authorities.

11.3   In
the event of any casualty caused by an event which is not covered by Landlord’s
insurance policy, the Landlord may elect to treat the casualty as though it had
insurance or it may terminate the Lease. If it treats the casualty as though it
had insurance then the provisions of this paragraph shall apply. The Landlord
shall serve a written notice upon the Tenant within fifteen (15) days of the casualty
specifying the election which it chooses to make.

11.4   In
the event the Landlord rebuilds, the Tenant agrees, at its cost and expense, to
forthwith remove any and all of its equipment, fixtures, stock and personal
property in order to permit Landlord to expedite the construction. The Tenant
shall assume at its sole risk the responsibility for damage to or security of
such fixtures and equipment in the event that any portion of the building area
has been damaged and is not secure.

12.                   COMPLIANCE
WITH LAWS, RULES AND REGULATIONS

12.1   (a)                               The Tenant agrees that upon acceptance and
occupancy of the Leased Premises, it will, at its own cost and expense, comply
with all statutes, ordinances, rules, orders, regulations and requirements of
the Federal, State and Municipal governments arising from the operations of
Tenant at the Leased Premises. The Tenant also agrees that it will not commit
any nuisance or excessive noise, and will dispose of all garbage and waste in
connection with its operations so as to avoid unreasonable emissions of dirt,
fumes, odors or debris.

(b)                         The Tenant agrees, at its own cost and
expense, to comply with such regulations or requests as may be required by the
fire or liability insurance carriers providing insurance for the Leased Premises,
and the Board of Fire Underwriters, in connection with Tenant’s use and
occupancy of the Leased Premises.

 10
 

12.2   In
case the Tenant shall fail to comply with all material provisions of the
aforesaid statutes, ordinances, rules orders, regulations and requirements then
the Landlord may, after ten (10) days notice (except for emergency repairs,
which may be made immediately), enter the Leased Premises and take any
reasonable actions to comply with them, at the cost and expense of the Tenant.
The cost thereof shall be added to the next month’s rent and shall be due and
payable as such, or the Landlord may deduct the same from the balance of any
sum remaining in the Landlord’s hands. This provision is in addition to the
right of the Landlord to terminate this Lease by reason of any default on the
part of the Tenant. However, in the event that all necessary repairs are made
by Tenant, the initial failure to comply with the aforesaid laws and
regulations shall not constitute an event of default.

12.3   Tenant
expressly covenants and agrees to indemnify, defend and save the Landlord
harmless against any claim, damage, liability, cost, penalties, or fines which
the Landlord may suffer as a result of air, ground or water pollution caused by
the Tenant in its use of the Leased Premises. The Tenant covenants and agrees
to notify the Landlord immediately of any claim or notice served upon it with
respect to any claim that the Tenant is causing air, ground or water pollution;
and the Tenant shall take immediate steps to halt, remedy or cure any pollution
of air, ground or water caused by the Tenant by its use of the Leased Premises.

12.4   Tenant
expressly covenants and agrees to fully  comply
with the provisions of the New Jersey Industrial Site Recovery Act (N.J.S.A.
13:1K-6, et seq.) “ISRA”, and its regulations, prior to the termination of the
Lease or at any time that any action of the Tenant triggers the applicability
of ISRA. In particular, the Tenant agrees that it shall comply with the
provisions of ISRA in the event of any “closing, terminating or transferring”
of Tenant’s operations, as defined by and in accordance with the regulations,
In the event evidence of such compliance is not delivered to the Landlord prior
to surrender of the Leased Premises by the Tenant to the Landlord, it is
understood and agreed that the Tenant shall be liable to pay to the Landlord an
amount equal to two times the Base Rent then in effect, together with all
applicable Additional Rent from the date of such surrender until such time as
evidence of compliance with ISRA has been delivered to the Landlord, and
together with any costs and expenses incurred by Landlord in enforcing Tenant’s
obligations under this paragraph. Evidence of compliance, as used herein, shall
mean a “letter of non-

 11
 

applicability” issued by the
New Jersey Department of Environmental Protection (“NJDEP”), an approved “negative
declaration” or a “remediation action plan” which has been fully implemented
and approved by NJDEP, or other equivalent document as may then be prescribed
by applicable regulations. Evidence of compliance shall be delivered to the
Landlord, together with copies of all submissions made to the NJDEP, including
all environmental reports, test results and other supporting documentation. In
addition to the above, Tenant agrees that it shall cooperate with Landlord in
the event ISRA is applicable to any portion of the property of which the Leased
Premises are a part. In such case, Tenant agrees that it shall fully cooperate
with Landlord in connection with any information or documentation which may be
requested by the NJDEP. In the event that any remediation of the Property is
required in connection with the conduct by Tenant of its business at the Leased
Premises, Tenant expressly covenants and agrees that it shall be responsible
for that portion of the remediation which is attributable to the Tenant’s
operation. Tenant hereby represents and warrants that its Standard Industrial
Classification No. is 8731, and that Tenant shall not generate, manufacture,
refine, transport, treat, store, handle or dispose of “hazardous substances” as
the same are defined under ISRA and the regulations promulgated pursuant
thereto, except in strict compliance with all governmental rules, regulations
and procedures. Tenant hereby agrees that it shall promptly inform Landlord of
any change in its SIC number and obtain Landlord’s consent for any change in
the nature of the business to be conducted in the Leased Premises. The within
covenants shall survive the expiration or earlier termination of the lease
term.

12.5   Landlord
represents and warrants to Tenant that it has no knowledge of any substance,
chemical, or waste on the Property that is identified as hazardous, toxic, or
dangerous (collectively, “Substance”) in any applicable federal, state, or
local law or regulation. Tenant will not introduce or use any Substance within
the Building or Office Park in violation of any applicable law. Landlord will
have sole responsibility for the identification, investigation, monitoring, and
remediation and/or cleanup of any Substance discovered at the Building or
Office Park unless the presence or release of the Substance is caused by the
activities of Tenant.

12.6   Landlord
represents and warrants, to the best of its knowledge, to Tenant that the
Office Park, and all improvements located thereon, are in substantial
compliance with building, life/safety, disability and other laws, codes and
regulations of applicable governmental authorities.

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13.                   INSPECTION
BY LANDLORD

The Tenant agrees that the Landlord shall have the
right to enter into the Leased Premises at all reasonable hours for the purpose
of examining the same upon reasonable advance notice of not less than
twenty-four (24) hours (except in the event of emergency), or to make such
repairs as are necessary. Any repair shall not unduly interfere with Tenant’s
use of the Leased Premises.

14.                   DEFAULT
BY TENANT

14.1   Each of the following shall be
deemed a default by Tenant and a breach of this Lease:

	
  (a)

  	
  (1)

  	
  filing of a petition by the Tenant for adjudication
  as a bankrupt, or for reorganization, or for an arrangement under any federal
  or state statute, except in a Chapter 11 Bankruptcy where the rent and
  Additional Rent stipulated herein is being paid and the terms of the Lease
  are being complied with;

  
	
   

  	
   

  	
   

  
	
   

  	
  (2)

  	
  dissolution or liquidation of the Tenant;

  
	
   

  	
   

  	
   

  
	
   

  	
  (3)

  	
  appointment of a permanent receiver or a permanent
  trustee of all or substantially all of the property of the Tenant, if such
  appointment shall not be vacated within sixty (60) days, provided the rent
  and Additional Rent stipulated herein is being paid and the terms of the
  Lease are being complied with, during said sixty (60) day period;

  
	
   

  	
   

  	
   

  
	
   

  	
  (4)

  	
  taking possession of the property of the Tenant by a
  governmental officer or agency pursuant to statutory authority for
  dissolution, rehabilitation, reorganization or liquidation of the Tenant if
  such taking of possession shall not be vacated within sixty (60) days,
  provided the rent and Additional Rent stipulated herein is being paid and the
  terms of the Lease are being complied with, during said sixty (60) day
  period;

  
	
   

  	
   

  	
   

  
	
   

  	
  (5)

  	
  making by the Tenant of an assignment for the
  benefit of creditors;

  
	
   

  	
   

  	
   

  
	
   

  	
  (6)

  	
  abandonment, desertion or vacation of the Leased
  Premises by the Tenant; and

  
	
   

  	
   

  	
   

  
	
   

  	
  (7)

  	
  failure of the Tenant to move into or take
  possession of the Leased Premises within fifteen (15) days of the
  Commencement Date.

  

 

 13
 

(b)                         Default in the payment of the rent or
Additional Rent herein reserved or any part thereof, which continues for ten
(10) days. For the first instance of overdue Rent or Additional Rent in any
twelve (12) month period, Landlord shall provide notice to Tenant and an
additional ten (10) days to cure.

(c)                          A default in the performance of any other
covenant or condition which this Lease requires the Tenant to perform, for a
period of fifteen (15) days after notice. However, no default on the part of
Tenant shall be deemed to exist if it diligently commences efforts to rectify
same and Landlord is indemnified against loss or liability arising from the
default.

14.2   In the event of any default set
forth above, Landlord may serve written notice upon the Tenant electing to
terminate this Lease upon a specified date not less than ten (10) days after
the date of serving such notice and this Lease shall then expire on the date so
specified as if that date had been originally fixed as the expiration date of
the term herein granted.

14.3   In case this Lease shall be
terminated due to Tenant’s default as set forth above, Landlord or its agents
may, immediately or any time thereafter, re-enter and resume possession of the
Leased Premises or such part thereof, and remove all persons and property
therefrom, either by summary proceedings or a suitable action or proceeding at
law, without being liable for any damages therefor. No re-entry by Landlord
shall be deemed an acceptance of a surrender of this Lease. However, if the
Tenant is in default and moves out, or is dispossessed, and fails to remove any
property, machinery, equipment and fixtures or other property within ten (10)
days of the date Landlord sends a written notice to the last known address of
the Tenant, then the property, machinery, equipment and fixtures or other
property left at the Leased Premises shall, at the option of the Landlord, be
conclusively presumed to be abandoned and may be disposed of by the Landlord
without accounting to Tenant for any of the proceeds, or the Landlord may
remove such property and charge the reasonable cost and expense of removal and
storage to the Tenant before disposing of such property. The Tenant shall be
liable for any damage that it causes in the removal of said property from the
Leased Premises.

14.4   In case this Lease shall be
terminated, due to Tenant’s default as set forth above Landlord may re-let the
whole or any portion of the Leased Premises for any period equal to or greater
or less than the remainder of the then current term, for any sum which it may
deem

 14
 

reasonable, to any tenant
which it may deem suitable and satisfactory, and for any use and purpose which
it may deem appropriate. In connection with any such lease, Landlord may make
such changes in the character of the improvements on the Leased Premises as
Landlord may determine to be appropriate or helpful in effecting such lease and
may grant concessions or free rent. Landlord shall make reasonable efforts to
re-let the Leased Premises. Landlord shall not in any event be required to pay
Tenant any sums received by Landlord on such re-letting of the Leased Premises.

14.5   In the event this Lease is
terminated due to Tenant’s default as set forth above, and whether or not the
Leased Premises be re-let, Landlord shall be entitled to recover from the
Tenant all rent due and all expenses, including reasonable counsel fees,
incurred by Landlord in recovering possession of the Leased Premises, and all
reasonable costs and charges for the care of the Leased Premises while vacant,
which damages shall be due at such time as they are incurred by Landlord; and
all other damages set forth in this Paragraph 14 and in Paragraph 15. Without
any previous notice or demand, separate actions may be maintained by Landlord
against Tenant from time to time to recover any damages which have become due
and payable to the Landlord without waiting until the end of the term.

15.                   LIABILITY OF
TENANT FOR DEFICIENCY

In the event that the relation of the Landlord and
Tenant terminates by reason of:

(a)             a default by the Tenant and the re-entry of
the Landlord as permitted herein;

(b)            by the ejectment of the Tenant by summary
proceedings or other judicial proceedings;

(c)             after the abandonment of the Leased Premises
by the Tenant, it is hereby agreed that the Tenant shall remain liable to pay
in monthly payments the rent and any other charges which shall accrue. The
Tenant expressly agrees to pay a portion of Landlord’s damages for such breach
of this Lease the difference between the Rent herein and the rent received, if
any, by the Landlord, during the remainder of the unexpired term.

16.                   NOTICES

All
notices required by this Lease shall be given either by certified mail, return
receipt requested, or overnight courier, or personal delivery with receipt, at
the address set forth on the first page of this Lease, and/or such other place
as the parties may designate in writing, with a copy, in the

 15
 

case of Tenant, to Price, Meese, Shulman & D’Aiminio,
P.C., Mack-Cali Corporate Center, 50 Tice Boulevard, Third Floor, Woodcliff Lake,
New Jersey 07677, Attention: Michael K. Breen, Esq.

17.                   NON-WAIVER
BY LANDLORD

The failure of Landlord to insist upon the strict
performance of any of the terms of this Lease, or to exercise any option
contained herein, shall not be construed as a waiver of any such term.
Acceptance by Landlord of performance of anything required by this Lease to be
performed, with the knowledge of the breach of any term of this Lease, shall
not he deemed a waiver of such breach, nor shall acceptance of rent in a lesser
amount than is due (regardless of any endorsement on any check, or any
statement in any letter accompanying any payment of rent) be construed either
as an accord and satisfaction or in any manner other than as payment on account
of the earliest rent then unpaid by Tenant. No waiver by Landlord of any term
of this Lease shall be deemed to have been made unless expressed in writing and
signed by Landlord.

18.                   RIGHT OF
TENANT TO MAKE ALTERATIONS AND IMPROVEMENTS

The Tenant may not make alterations, additions or
improvements to the Leased Premises, or change the door locks or window
coverings, or in any way alter access to the Leased Premises without the
consent of the Landlord. Landlord agrees to review any alterations, additions,
or improvements proposed by Tenant within fifteen (15) days of receipt of plans
and specifications, and advise Tenant of its decision. Any approval given is
not intended to subject the Landlord’s property to liability under any lien
law. Tenant shall be responsible for obtaining at its own cost and expense all
licenses, permits and approvals that may be required by any governmental entity
having jurisdiction over the approved alterations, additions and/or
improvements. Tenant shall furnish to Landlord as-built drawings of any alterations,
additions or improvements which are made. Notwithstanding the foregoing,
Landlord’s consent shall not be required for any interior, non-structural,
non-mechanical alteration for which, in each instance, (i) the cost of
performing does not exceed $5,000.00, and (ii) does not require a Building
Permit.

19.                   NON-LIABILITY
OF LANDLORD

Tenant agrees to assume all risk of damage to its
property, equipment and fixtures occurring in or about the Leased Premises,
whatever the cause of such damage or casualty, except when caused by the
Landlord’s gross negligence or willful misconduct. Landlord shall not be liable

 16
 

for any damage or injury to property or person caused
by or resulting from steam, electricity, gas, water, rain, ice or snow, or any
leak or flow from or into any part of the building, or from any damage or
injury resulting or arising from any other cause or happening whatsoever,
except when caused by the Landlord’s gross negligence or willful misconduct.

20.                   RESERVATION
OF EASEMENT

Landlord reserves the right, easement and privilege
to enter on the Leased Premises in order to install, at its own cost and
expense, any utility lines and services in connection therewith as may be
required by the Landlord. It is understood and agreed that if such work as may be
required by Landlord requires any interior installation, or displaces any
exterior paving or landscaping, the Landlord shall at its own cost and expense,
restore such items, to substantially the same condition as they were before
such work. The Landlord covenants that the foregoing work shall not
unreasonably interfere with the normal operation of Tenant’s business.

21.                   STATEMENT OF
ACCEPTANCE

Upon the delivery of the Leased Premises to the
Tenant the Tenant covenants and agrees that it will furnish to Landlord a
statement which shall set forth the Date of Commencement and the Date of
Expiration of the lease term.

22.                   FORCE
MAJEURE

Except for the obligation of the Tenant to pay Rent
and other charges, the period of time during which the Landlord or Tenant is
prevented from performing any act required to be performed under this Lease by
reason of fire, catastrophe, strikes, lockouts, civil commotion, weather
conditions, acts of God, government prohibitions or preemptions or embargoes,
inability to obtain material or labor by reason of governmental regulations,
the act or default of the other party, or other events beyond the reasonable
control of Landlord or Tenant, as the case may be, shall be added to the time
for performance of such act.

23.                   STATEMENTS
BY LANDLORD AND TENANT

Landlord and Tenant agree at any time and from time
to time upon not less than five (5) business days prior notice from the other
to execute, acknowledge and deliver to the party requesting same, a statement
in writing, certifying that this Lease is unmodified and in full force and
effect (or if there have been modifications, that the same is in full force and
effect as modified and

 17
 

stating the modifications),
that it is not in default (or if claimed to be in default, stating the amount
and nature of the default) and specifying the dates to which the Rent and other
charges have been paid in advance.

24.                   CONDEMNATION

24.1   If due to condemnation, (i)
more than fifteen (15%) percent of the Leased Premises is taken or rendered
untenantable, or (ii) more than twenty-five (25%) percent of the ground is
taken (including parking areas, but excluding front, side and rear set back
areas) and, in Landlord’s reasonable opinion, said taking unreasonably or
unduly interferes with the use of the Leased Premises, the lease term created
shall terminate from the date when the authority exercising the power of
eminent domain takes or interferes with the use of the Property. The Tenant
shall be responsible for the payment of Rent until the time of surrender. In
any event, no part of the Landlord’s condemnation award shall be claimed by the
Tenant. Without diminishing Landlord’s award, the Tenant shall have the right
to make a claim against the condemning authority for such independent claim
which it may have.

24.2   In the event of any partial
taking which would not be cause for termination of the Lease, or in the event
of any taking in excess of the percentages provided above and Tenant retains
the balance of the Leased Premises remaining after such taking, then the Rent
shall abate in an amount to be mutually agreed upon between the Landlord and
Tenant based on the relationship that the character of the property prior to
the taking bears to the property which shall remain after the condemnation. The
Landlord shall, to the extent permitted by applicable law and as the same may
be practicable, promptly make such repairs and alterations in order to restore
the Building and/or improvements to a usable condition to the extent of any
condemnation award received by Landlord.

25.                   LANDLORD’S
REMEDIES

25.1   The rights and remedies given
to the Landlord in this Lease are distinct, separate and cumulative remedies,
and no one of them, whether or not exercised by the Landlord, shall be deemed
to be in exclusion of any of the others.

25.2   In
addition to any other legal remedies for violation or breach of this Lease by
the Tenant or by anyone holding or claiming under the Tenant such violation or
breach shall be restrainable by injunction at the suit of the Landlord.

 18
 

25.3   No
receipt of money by the Landlord from any receiver, trustee or custodian or
debtors in possession shall reinstate, or extend the term of this Lease or
affect any notice theretofore given to the Tenant, or to any such receiver,
trustee, custodian or debtor in possession, or operate as a waiver or estoppel
of the right of the Landlord to recover possession of the Leased Premises for
any of the causes therein enumerated by any lawful remedy; and the failure of
the Landlord to enforce any covenant or condition by reason of its breach by
the Tenant shall not be deemed to void or affect the right of the Landlord to
enforce the same covenant or condition on the occasion of any subsequent
default or breach.

26.                   QUIET
ENJOYMENT

The Landlord covenants that the Tenant, on paying the
Rent and performing the covenants and conditions contained in this Lease, may
peaceably and quietly have, hold and enjoy the Leased Premises, in the manner
of a multi-tenanted building, for the Lease term.

27.                   SURRENDER
OF PREMISES

On the last day, or earlier permitted termination of
the Lease, Tenant shall quit and surrender the Leased Premises in good and
orderly condition and repair (reasonable wear and tear, and damage by fire or
other casualty excepted) and shall deliver and surrender the Leased Premises to
the Landlord peaceably, together with all Tenant Improvements. The Landlord
reserves the right, however, to require the Tenant at its cost and expense to
remove any alterations or improvements installed by the Tenant, and restore the
Leased Premises to its original state, normal wear and tear excepted. Prior to
the expiration of the Lease term the Tenant shall remove all of its tangible
property, fixtures and equipment from the Leased Premises. All property not
removed by Tenant shall be deemed abandoned by Tenant, and Landlord reserves
the right to charge the reasonable cost of such removal and disposal to the
Tenant. If the Leased Premises are not surrendered at the end of the Lease
term, the Tenant shall be liable for double rent under N.J.S.A. 2A:42-6,
and Tenant shall indemnify Landlord against loss or liability resulting from
delay by Tenant in surrendering the Leased Premises, including, without
limitation any claims made by any succeeding tenant founded on the delay, and
any loss of income suffered by Landlord. These covenants shall survive the
termination of the Lease.

 19
 

28.                   INDEMNITY

Landlord indemnifies and agrees to defend Tenant
against and holds Tenant harmless from any and all costs (including reasonable
attorney’s fees) and claims of liability or loss which arise out of Landlord’s
ownership, use, and occupancy of the Office Park or Building. The indemnity
obligations under this Section will survive termination of this Lease
Agreement.

Anything in this Lease to the contrary
notwithstanding, and without limiting the Landlord and/or Tenant’s obligation
to provide insurance hereunder, the Landlord and/or Tenant covenants and agrees
that it will indemnify, defend and save harmless the Landlord against and from
all liabilities, obligations, damages, penalties, claims, costs, charges and
expenses, including without limitation reasonable attorneys’ fees, which may be
imposed upon or incurred by Landlord and/or Tenant by reason of any of the
following occurring during the term of this Lease:

(a)             Any matter, cause or thing arising out of
Landlord and/or Tenant’s use, occupancy, control or management of the Leased
Premises and any part thereof.

(b)            Any negligence on the part of the Landlord
and/or Tenant or any of its agents, employees, licensees or invitees, arising
in or about the Leased Premises.

(c)             Any failure on the part of Landlord and/or
Tenant to perform or comply with any of its covenants, agreements, terms or
conditions contained in this Lease.

Landlord and/or Tenant shall promptly notify the
other of any such claim asserted against it and shall promptly send to the
other copies of all papers or legal process served upon it in connection with
any action or proceeding brought against Landlord and/or Tenant.

29.                   BIND AND CONSTRUE CLAUSE

The terms, covenants and conditions of this Lease
shall be binding upon, and inure to the benefit of, each of the parties hereto
and their respective heirs, successors and assigns. If any one of the
provisions of this Lease shall be held to be invalid by a court of competent
jurisdiction, such adjudication shall not affect the validity or enforceability
of the remaining portions of this Lease. The parties each acknowledge to the
other that this Lease has been drafted by both parties, after consultation with
their attorneys, and in the event of any dispute, the provisions are not to be
interpreted against either party as the drafter of the Lease.

 20
 

30.                   INCLUSIONS

The neuter gender when used herein, shall include all
persons and corporations, and words used in the singular shall include words in
the plural where the text of the instrument so requires.

31.                   DEFINITION
OF TERM “LANDLORD”

When the term “Landlord” is used in this Lease it
shall be construed to mean and include only the entity which is the owner of
title to the building. Upon the transfer by the Landlord of the title, the
Landlord shall advise the Tenant in writing by certified mail, return receipt
requested, of the name of the Landlord’s transferee, in such event, the
Landlord shall be automatically freed and relieved from and after the date of
such transfer of title of all personal liability with respect to the
performance of any of the covenants and obligations on the part of the Landlord
herein contained to be performed, provided any such transfer and conveyance by
the Landlord is expressly subject to the assumption by the transferee of the
obligations of the Landlord hereunder.

32.                   COVENANTS OF FURTHER ASSURANCES

If, in connection with obtaining financing for the
improvements on the Leased Premises, the mortgage lender shall request
reasonable modifications in this Lease as a condition to such financing, Tenant
will not unreasonably withhold, delay or refuse its consent thereto, provided
that such modifications do not in Tenant’s reasonable judgment increase the
obligations of Tenant hereunder or materially adversely affect the leasehold
interest hereby created or Tenant’s use and enjoyment of the Leased Premises.

33.                   COVENANT AGAINST LIENS

Tenant agrees that it shall not encumber, or permit
to be encumbered, the Leased Premises or the fee thereof by any lien, charge or
encumbrance, and Tenant shall have no authority to mortgage or hypothecate this
Lease in any way whatsoever. Any violation of this Paragraph shall be
considered a breach of this Lease.

34.                   SUBORDINATION

This Lease shall be subject and subordinate at all
times to the lien of any mortgages or ground leases or other encumbrances now
or hereafter placed on the land, Building and Leased Premises without the
necessity of any further instrument or act on the part of Tenant to effectuate

 21
 

such subordination. However,
Tenant agrees to execute such further documents evidencing the subordination of
the Lease to the lien of any mortgage or ground lease as shall be desired by
Landlord within five (5) business days. Tenant appoints Landlord the attorney
in fact of the Tenant irrevocably, to execute and deliver any such instrument
or instruments for and in the name of Tenant, with a copy of the signed
document sent to Tenant and Tenant’s legal advisor.

35.                   EXCULPATION OF LANDLORD

The Landlord’s principals shall not have any personal
obligation for the payment of any indebtedness or for the performance of any
obligation under this Lease. The performance of Landlord’s obligations
expressed herein may be enforced only against the assets of Landlord known as
1000 Eastpark Boulevard, 2000 Eastpark Boulevard (a/k/a the Building), 3000
Eastpark Boulevard, and the land of which the Leased Premises are apart, and
the rents, issues, and profits thereof. The Tenant agrees that no deficiency
judgment or other judgment for money damages shall be entered by it against the
Landlord’s principals personally in any action. Notwithstanding anything to the
contrary set forth in this Lease, it is specifically understood and agreed by
Landlord that there shall be absolutely no personal liability on the part of
Tenant or on the part of the partners of Tenant with respect to any of the
terms, covenants, and conditions of this Lease, and Landlord shall look solely
to the equity, if any, of Tenant in the event of any breach by Tenant of any of
the terms, covenants, and conditions of this Lease to be performed by Tenant;
such exculpation of personal liability to be absolute and without any exception
whatsoever.

36.                   NET RENT

It is the intent of the Landlord and Tenant that this
Lease shall yield, net to Landlord, the Base Rent specified and all Additional
Rent and charges in each month during the term of the Lease, and that all
costs, expenses and obligations of every kind relating to the Leased Premises
shall be paid by the Tenant, unless expressly assumed by the Landlord.

37.                   SECURITY

Upon execution of this Lease, the Tenant shall
deposit with the Landlord two (2) months Base Rent ($27,200.00) as security for
the full and faithful performance of its obligations under this Lease. Upon
termination of this Lease, and providing the Tenant is not in default hereunder
and has performed all of the conditions of this Lease, the Landlord shall
return the security

 22
 

deposit to the Tenant within thirty  (30) days. Tenant covenants and agrees
that it will not assign, pledge, hypothecate, mortgage or otherwise encumber
the security during the term of this Lease. It is expressly understood and
agreed that the Landlord shall not be required to segregate the security.

38.                   BROKERAGE

The parties mutually represent to each other that
Insignia/ESG is the only broker who negotiated and consummated the within
transaction, and that neither party dealt with any other broker in connection
with the Lease. In the event either party violates this representation, it
shall indemnify, defend and hold the other party harmless from all claims and
damages. It is agreed that the Landlord shall be responsible, at its sole cost
and expense, to pay the brokerage commission in connection with this Lease.

39.                   LATE CHARGES

In addition to any other remedy, a late charge of one
and one-half (1-1/2%) percent per month, retroactive to the date Rent was due,
shall be due and payable, without notice from Landlord, on any portion of Rent
or other charges not paid within five (5) days of the due date.

40.                   PRESS RELEASES

Subject to the prior written approval of Tenant
(which shall not be unreasonably withheld), Landlord shall have the right to
announce the execution of this Lease, the parties hereto, and the real estate
brokers involved in such press releases as Landlord shall deem advisable. In
addition, Tenant shall permit Landlord to use its name and photographs of the
Leased Premises (all photographs being subject to Tenant’s prior consent) in
Landlord’s marketing brochures and materials, and Tenant agrees to reasonably
cooperate with Landlord in such regard, but at no cost or expense to Tenant.

41.                   WAIVER OF JURY TRIAL

Landlord and Tenant both irrevocably waive a trial by
jury in any action or proceeding between them or their successors or assigns
arising out of this Lease or any of its provisions, or Tenant’s use or
occupancy of the Leased Premises. In any suit instituted by either Landlord or
Tenant, including for the collection of rent or for possession of the Leased
Premises, the losing party shall reimburse the prevailing party for all
reasonable expenses incurred by the prevailing party in connection therewith,
including, but not limited to, reasonable attorney’s fees.

 23
 

42.                   LAWS
OF NEW JERSEY

Without
regard to principles of conflicts of laws, the validity, interpretation,
performance and enforcement of this Lease shall be governed by and construed in
accordance with the laws of the State of New Jersey. The sole and exclusive venue
for any dispute between the parties shall be in Middlesex County, New Jersey.

43.                   OPTION
TO RENEW

Provided
the Tenant is not in default hereunder, it has the right to renew the Lease,
for one (1) five-year period, to commence at the end of the initial term of
this Lease. The renewal shall be upon the same terms and conditions as
contained in this Lease, except as follows:

(a)             The original Base
Rent of $163,200.00 shall be increased by fifteen (15%) percent to $187,680.00
annually, which shall be payable monthly at the rate of $15,640.00.

(b)            The option of the
Tenant to renew this Lease is expressly conditioned upon the Tenant delivering
to the Landlord a notice, in writing, by certified mail, return receipt
requested, one hundred twenty (120) days prior to the date fixed for
termination of the original Lease term.

44.                   ADJACENT
SPACE

The
unit adjacent to the Leased Premises is currently vacant and consists of
approximately 5,100 square feet of space (the “Adjacent Space”). During the
Term, and prior to Landlord entering into substantive negotiations with any
prospective tenant, Landlord shall provide notice to Tenant (the “Adjacent
Space Offer”) consisting of an offer to lease the Adjacent Space under a
specified rent and term (with all other terms and conditions being identical to
this Lease). Tenant shall have ten (10) days to accept the Adjacent Space
Offer, after which the Adjacent Space Offer shall expire. Tenant agrees to keep
the terms of the Adjacent Space Offer strictly confidential. In the event that
the Tenant, during the term of this Lease, enters into a further lease
agreement whereby it rents the entire Adjacent Space, then the rent on these
Leased Premises (2005 Eastpark Boulevard) shall decrease to $28.00/square foot,
effective with the commencement date of the lease on the Adjacent Space. The
minimum term for the leasing of this Adjacent Space shall be five (5) years.

 24
 

IN WITNESS WHEREOF, the
parties hereto have executed this document on the date first above written.

	
  

  	
  EASTPARK AT 8A, a general partnership

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
  Date:

  	
  12-9-02

  	
   

  	
  By:

  	
  /s/ A. Joseph Stern

  	
   

  
	
   

  	
   

  	
  A. Joseph Stern, Partner

  
	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  
	
   

  	
  LINGUAGEN CORP.

  
	
   

  	
   

  
	
   

  	
   

  
	
  Date:

  	
  12-11-02

  	
   

  	
  By:

  	
  /s/ Richard C. Lufkin

  	
   

  
	
   

  	
   

  	
  Tenant

  	
   

  
							

 

 25Exhibit 10.5

AGREEMENT
BETWEEN

ALBERT

EINSTEIN HEALTHCARE NETWORK

AND

LINGUAGEN

This Agreement is entered
into by and between Linguagen Corp., a Delaware corporation (“Linguagen”),
and Albert Einstein Healthcare Network (“AEHN”), a non-profit
corporation in Philadelphia, PA, as of September 30, 2005 (the “Effective
Date”).

WHEREAS, Linguagen wishes
to use AEHN’s animal facilities located at 5501 Old York Road, Philadelphia, PA
19141 (“Facility”) for executing Linguagen Protocols (as defined below)
and AEHN has unoccupied space which is available in its Facility that may be
leased to Linguagen for its use.

WHEREAS, Linguagen in
conjunction with its use of the Facility for performing its Protocol proposes
to retain the services of AEHN to care and maintain its laboratory animals (“Services”).

NOW, THEREFORE, in
consideration of the mutual covenants contained herein, the parties hereby
agree to be legally bound as follows:

ARTICLE
I – STATEMENT OF WORK

AEHN shall make the
Facility available and perform Services for Linguagen in connection with
Linguagen’s protocol attached hereto as Exhibit A and any additional
protocols that Linguagen may from time to time perform at the Facility
(collectively, “Protocols”). Notwithstanding the foregoing, all
Protocols must be approved by AEHN’s Institutional Animal Care and Use
Committee “IACUC”) in accordance with the “Animal Use Protocol” attached
hereto as Exhibit B. In addition to Linguagen personnel authorized to
conduct Protocols at the Facility, Linguagen shall be allowed to have visitors
at the Facility, provided, that such visitors shall be supervised by either
Linguagen personnel or AEHN personnel at all times.

ARTICLE
II – PERIOD OF PERFORMANCE

This Agreement shall
begin on September 30, 2005 and shall not extend beyond September 30, 2006
unless the period is extended in writing by mutual agreement of the parties.

ARTICLE
III – CONSIDERATION

Linguagen shall pay AEHN
in accordance with the budget attached hereto as Exhibit C (“Budget”).
AEHN shall submit a detailed invoice for all amounts payable under this
Agreement on the last business day of each month in which the Facility is used
by Linguagen or on which AEHN performs Services. Payment of any undisputed
amounts shall be made within thirty (30) days of receipt of a proper invoice.
Checks shall be made payable to Albert Einstein Healthcare Network and sent to:

Attention: Dan Lyons

Office for Research and Technology Development

Albert Einstein Healthcare Network

 1
 

5501 Old York Road, Korman 100

Philadelphia, PA 19141

AEHN Tax ID number is
23-2290323

ARTICLE
IV – INTELLECTUAL PROPERTY RIGHTS

A.                     Linguagen
shall have worldwide right, title and interest in and to any and all
inventions, original works of authorship, findings, conclusions, data,
discoveries, developments, concepts, improvements, trade secrets, techniques,
processes and know-how, whether or not patentable or registrable under patent,
copyright or similar laws, that AEHN (through its employees) may solely or
jointly conceive, develop or reduce to practice, or cause to be conceived,
developed or reduced to practice, in the performance of the Services
(collectively, the “Inventions”), including any and all moral rights and
intellectual property rights inherent therein and appurtenant thereto,
including, but not limited to, all patent rights, copyrights, trademarks,
know-how and trade secrets and the rights to apply for the same (collectively, “Intellectual
Property Rights”.

B.                       Upon
the request and at the expense of Linguagen, AEHN shall execute and deliver any
and all instruments and documents and take such other acts as may be necessary
or desirable to document the assignment and transfer described in Paragraph A
of Article IV herein or to enable Linguagen to secure its rights in the
Inventions and Intellectual Property Rights relating thereto in any and all
jurisdictions, or to apply for, prosecute and enforce Intellectual Property
Rights in any and all jurisdictions with respect to any Inventions or to obtain
any extension, validation, re-issue, continuance or renewal of any such
Intellectual Property Right. Without limiting the foregoing, AEHN shall
disclose to Linguagen all pertinent information and data with respect thereto
and shall execute all applications, specifications, oaths and all other
instruments which Linguagen deems necessary in order to apply for and obtain
such rights and in order to assign and convey to Linguagen the sole and
exclusive right, title and interest in and to such Inventions and any
Intellectual Property Rights relating thereto. If Linguagen is unable for any
other reason to secure AEHN’s signature to apply for or to pursue any
application for any United States or foreign patent, trademark, copyright or
other registration covering Inventions assigned to Linguagen hereunder, then
AEHN hereby irrevocably designates and appoints Linguagen and its duly
authorized officers and agents as AEHN’s agent and attorney in fact, to act for
and in AEHN’s behalf and stead to execute and file any such applications and to
do all other lawfully permitted acts to further the prosecution and issuance of
letters patent or trademark, copyright or other registrations thereon with the
same legal force and effect as if executed by AEHN.

ARTICLE
V – ADMINISTRATIVE PERSONNEL

The contract
administrator for AEHN is Mary Klein and the technical administrator for AEHN
is Dan Lyons. The above personnel at AEHN can be contacted at (215) 456-7215.
The technical and contract administrator for Linguagen is Heather Kaminski, who
can he contacted at (609)-860-1500.

 2
 

ARTICLE VI – TERMINATION

Either party may
terminate this Agreement upon thirty (30) days written notification to the
other party.

A.                     In
the event of termination by Linguagen, AEHN will be reimbursed for any non-
cancelable obligations properly and reasonably incurred prior to the date of
notice of termination

B.                       In
the event of early termination without “cause” by AEHN, AEHN will provide
general cooperation and assistance in the transfer of all animals housed at
AEHN’s Facility and shall reimburse Linguagen for all reasonable costs
associated with such transfer. For purposes of clarity “cause” shall mean
Linguagen’s failure to perform any of the following obligations: (a) to make
payments of any undisputed amount due under the terms of this agreement within
thirty (30) days of receipt of the proper invoice, (b) to comply with the Guide
for the Care of Use of Laboratory Animals included in the Animal Use Protocol
attached hereto as Exhibit B, (c) to comply with AEHN’s attending veterinarian
orders and/or instructions, or (d) to properly monitor Linguagen personnel at
the Facility for any condition or behavior which might reasonably and adversely
affect the working environment at the Facility, or (e) to replace disruptive or
offending Linguagen personnel from the Facility upon the reasonable request of
AEHN.

ARTICLE
VII – INDEMNIFICATION

A.                     Linguagen
shall defend, indemnify and hold harmless AEHN, its trustees, officers, agents,
and employees from any and all liabilities, loss or damages, costs, judgments,
claims, actions or suits (“Claims”) arising out of or in connection with
the activities carried out pursuant to this Agreement. Notwithstanding the
foregoing, Linguagen shall not be obligated to indemnify for any Claim where
(a) such Claim is caused by gross negligence or willful malfeasance of AEHN,
its IACUC, trustees, officers, agents, or employees, (b) Linguagen is not
promptly notified of such Claim, (c) Linguagen does not have sole control over
the defense and settlement of such Claim, or (d) Linguagen does not have the
right to select defense counsel and to direct the defense or settlement of such
Claim.

B.                       AEHN
shall defend, indemnify and hold harmless Linguagen, its, officers, board
members, agents, and employees from any and all Claims arising from (a) a
material breach of this Agreement by AEHN, or any other trustee, officer,
agent, or employee of AEHN, or (b) gross negligence or intentional misconduct
on the part of AEHN or any trustee, officer, agent or employee of AEHN.
Notwithstanding the foregoing, AEHN shall not be obligated to indemnify for any
Claim where (a) such Claim is caused by gross negligence or willful malfeasance
of Linguagen, its officers, agents, or employees, (b) AEHN is not promptly
notified of such Claim, (c) AEHN does not have sole control over the defense
and settlement of such Claim, or (d) AEHN does not have the right to

 3
 

select defense counsel and to direct the defense or
settlement of such Claim.

C.                       The
indemnifying party shall provide a diligent defense against or settlement of
any claims brought or actions filed with respect to the subject of the
indemnity contained herein, whether such claims or actions are rightfully or
wrongfully brought or filed. The indemnifying party shall have the right to
settle Claims at its sole expense, provided, that the indemnifying party may
not settle a claim without the written consent of the indemnified party, which
consent shall not be unreasonably withheld or delayed.

D.                      The
indemnitee shall cooperate with indemnifying party and its legal
representatives in the investigation and defense of any Claim under this
Agreement. In the event a Claim is asserted, the indemnitee shall have the
right to select and to obtain representation by separate legal counsel. If the
indemnitee exercises such right, all costs and expenses incurred by indemnitee
for such separate counsel shall be borne solely by the indemnitee.

ARTICLE
VIII – USE OF NAMES

AEHN and Linguagen will
obtain prior written permission from each other before using the name, symbols
and/or marks of the other in any form of publicity in connection with the
Agreement. Notwithstanding the foregoing, such written approval shall not be
required for disclosure (a) by either party of the existence of this Agreement,
(b) Linguagen’s use of the name, symbols and/or marks of AEHN as the operative
site where the Protocol was performed, or (c) as required by law.

ARTICLE
IX – ENTIRE AGREEMENT

This Agreement
constitutes the entire agreement between the parties regarding the subject
matter herein. Any changes to this Agreement shall be made in writing and must
be signed by authorized representatives or designees of each party. No waiver
of any rights under this Agreement shall be effective unless in writing signed
by the party to be charged. A waiver of a breach or violation of any provision
of this Agreement will not constitute or be construed as a waiver of any
subsequent breach or violation of that provision or as a waiver of any breach
or violation of any other provision of this Agreement.

ARTICLE
X – MISCELLANEOUS

A.                     All
notices and other communications required or permitted hereunder shall be in
writing and deemed to have been given when hand delivered, sent by facsimile or
mailed by registered or certified mail or overnight courier with tracking
capabilities, as follows or as a party may otherwise notify to the other in
accordance with this Section 5.2 (provided, that such notice of change
of address or recipient shall be deemed given only when received at the address
listed below.

B.                       This
Agreement shall be governed and interpreted in accordance with the law of the
Commonwealth of Pennsylvania without giving effect to any conflict of laws

 4
 

provisions. The parties agree that any dispute or
controversy arising out of or relating to any interpretation, construction,
performance or breach of this Agreement may be brought in the United States
District Court in Pennsylvania, or if such court does not accept jurisdiction
or will not accept jurisdiction, in any court of general jurisdiction in the
Commonwealth of Pennsylvania.

C.                       If
any provision of this Agreement or application thereof to anyone or under any
circumstances is adjudicated to be invalid or unenforceable in any
jurisdiction, such invalidity or unenforceability shall not affect any other
provision or application of this Agreement which can be given effect without
the invalid or unenforceable provision or application and shall not invalidate
or render unenforceable such provision or application in any other
jurisdiction.

D.                      This Agreement may be executed in two counterparts and by facsimile,
each of which shall be deemed to be an original as against any party whose
signature appears thereon, but both of which together shall constitute but one
and the same instrument.

[SIGNATURE PAGE FOLLOWS]

 5

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as
of the 30 day of September, 2005.

	
  LINGUAGEN CORP

  2005 Eastpark Boulevard

  Cranbury, NJ 08512-3515

  	
   

  	
  ALBERT EINSTEIN

  HEALTHCARE NETWORK

  Office for Research and Technology

  5501 Old York Road, Korman 100

  Philadelphia, PA 19141

  

 

	
  /s/ Scott Horvitz

  	
   

  	
   

  	
  /s/ Mary Klein

  	
   

  
	
  Scott Horvitz

  Chief Financial Officer

  	
   

  	
  Mary Klein, PhD

  Director, Office of Research and

  Technology Development

  

 

	
  9.30.05

  	
   

  	
   

  	
  10/6/05

  	
   

  
	
  Date

  	
   

  	
  Date

  

 

	
  Approved

  	
  Illegible

  	
   

  
	
  Finance

  	
  9/30/05

  	
   

  
	
  Legal

  	
  Illegible

  	
   

  
					

 

 1

Exhibit A

Animal Use Protocol

	
  Albert
  Einstein Healthcare Network

  
	
  Animal
  Care Committee

  
	
  ANIMAL
  USE PROTOCOL APPLICATION

  

A.                       Administrative
Information

1.                         INDICATE
YOUR SELECTION BY CHECKING ALL THAT ARE APPROPRIATE.

	
  x

  	
   

  	
  New:

  
	
  o

  	
   

  	
  Renewal:

  
	
  o

  	
   

  	
  Revision:

  
	
  o

  	
   

  	
  Pilot Study:

  
	
  o

  	
   

  	
  Other:

  

 

2.                         PROTOCOL
TITLE:                          Lickometer
Taste Testing in Mice

3.                         PRINCIPAL
INVESTIGATOR(S):                         Kyle Palmer, PhD

4.                         PHONE:                       609-860-1500
x226

5.                         BEEPER:                   609-858-8797

6.                         E-MAIL:                       kyle.palmer@linguagen.com

7.                         DEPARTMENT/LOCATION:
:  Linguagen Corp.

8.                         DEPARTMENT
CHAIRPERSON:

9.                         TECHNICIAN(S)/CO-INVESTIGATOR(S)DEPT.(S)           TITLE(S)            PHONE

Heather Kaminski, Senior Research Associate     609-860-1500 x 216

10.                  CONTACT PERSON (S) FOR AFTER NORMAL WORKING
HOURS: List name(s) to contact in the event there is a need to reach
a protocol participant for animal care problems that occur after normal working
hours or when the Principal Investigator is not available. Heather Kaminski.
908-578-6859

B.                       PROJECT
DESCRIPTION

1.                         START
DATE:                       October
2005

2.                         FINISH
DATE:                        October
2008

 1
 

3.                         PURPOSE: To
ascertain difference in taste preference of solutions containing either a
standard tastant or a novel compound tastant in mice.

4.                         ABSTRACT: In order to determine taste preference in mice we
will be using a behavioral study known as a lickometer test. This test will
allow us to determine if there is an aversion to a liquid substance based on
the taste of the animal. We want to use this assay in order to determine if a
substance can be used to alleviate an aversive bitter taste to mice. These
substances will be important because they can potentially be used to modify
bitter taste in human which can help patients comply with oral regimens

5.                         LAYMAN’S
PARAGRAPH: Humans have an aversion to bitter taste which is beneficial in
avoiding toxic compounds. However, when prescribing oral suspension of drugs,
especially in pediatric and geriatric patients, aversion the the bitterness of
the drugs leads to a lack of compliance. In order to monitor substance which
may block bitter taste we will be using mice to measure aversion. This aversion
is measured through a behavioral apparatus called a lickometer. The lickometer
is a modified mouse cage which allows a mouse to “taste” a small amount of
liquid during a short period of time. The number of licks or tastes the mouse
takes is recorded by computer. This number is then used in comparison to a
nonbitter compound, usually water, to determine if the compound does not taste
well to the animal. In this manner one can add additional compounds to bitter
ones to monitor any effect they may have in alleviating the aversive taste to
mice.

6.                         DESCRIBE
METHODS AND PROCEDURES SPECIFIC TO THE ANIMAL USE IN THE PROTOCOL: Mice
will be tested in an automated lickometer referred to as the ‘Davis Rig’ (DiLog
Instruments, Tallahassee, FL) The Davis Rig allows presentation of up to 16
different taste stimuli within a single behavioral session, with duration and
order of stimuli presentation at control of technician. The test chamber is a
rectangular cage made of plastic with a wire mesh floor. An opening in the
center of the front wall gives animals access to a sipper tube that contains a
taste solution. Fluid access is controlled by a computer operated shutter. The
amount of licks will be monitored for each session using a high frequency AC
contact circuit. Mice will be water deprived ON (~15 hours) prior to the
initial test session of the week. Mice will have access to water ad libitum in
their own cages except during the initial ON restriction. The first session
will allow mice to learn that water is available to them through the sipper
tube by exposing the animal to the open sipper tube containing distilled water
for 20 minutes. The next session will allow the mouse to learn brief-access
trials. The same distilled water will be used in this trial but instead of 20
minutes the animal will be exposed to 15 second intervals of open shutter until
30 trials were reached. Testing will occur over the next three days in three
identical sessions. The 30 trials will now be broken into 5 blocks of 6 trials
each where each of the 6 trials contains a different tastant solution. Mice
will be kept in the rigs no more then 30 minutes per trial. Number of licks
again will be monitored and compared to a set of standard compounds including
quinine, ranitidine, and cyclohexamide. Mice will be weighed periodically to
monitor weight loss and mice losing more then 20% body weight will be removed
from testing. After a 5 day test mice will be given a rest period before
another test begins.

 2
 

C.                       ANIMAL
SELECTION

1.                         SPECIES:               Mus musculus

2.                         STRAIN:                   C57/BI6

3.                         SEX:     F/M

4.                         AGE
AND/OR WEIGHT RANGE:                             18-20g

5.                         SOURCE: Taconic

PLEASE JUSTIFY THE SELECTION OF A VENDOR NOT
ON THE LIST:

6.                         JUSTIFY
THE USE OF LIVING ANIMALS: The complexity of the processes being study
cannot be duplicated or modeled in simpler systems.

7.                         JUSTIFY
THE APPROPRIATENESS OF THE SPECIES SELECTED FOR THE STUDY: This species
provides a good model for duplicating the human response to aversive bitter
tastes.

8.                         TOTAL
NUMBER OF ANIMALS TO BE USED IN THIS PROTOCOL:   120

9.                         RATIONALE
FOR DETERMINING THE NUMBER OF ANIMALS NEEDED: We will use 4 groups of ten
animals each. Group 1 will have water and compound A. Group 2 will have water
and drug B. Group 3 will have x and standard A. Group 4 will be controls (water
and no drugs). Data will be compared using a Student’s “T” test. From previous
experiments, we estimate that ten will be an adequate group size to show
significant results. Each of the 4 groups can be used for 3 (1 week) studies.

D.                       PRE-ANESTHESIA
/ ANESTHESIA / SEDATIVES / ANALGESICS

1.                          If Sedation, analgesics, tranquilizers. and /or
anesthesia is (are) used, please Identify below. (see appendices for
recommendations)

a.

	
  PRE-ANESTHETIC OR

  SEDATIVE AGENT

  	
   

  	
  DOSE

  	
   

  	
  ROUTE

  	
   

  	
  VOLUME

  	
   

  	
  FREQUENCY

  OF DOSING

  	
   

  	
  DURATION OF

  TREATMENT

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  N/A

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
     

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  

 

b.

	
  ANESTHETIC DRUG

  	
   

  	
  INITIAL

  DOSE

  	
   

  	
  SUPPLEMENT

  DOSE

  	
   

  	
  ROUTE

  	
   

  	
  EXPECTED TIME UNDER

  ANESTHESIA

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  N/A

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
     

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  

 3
 

c.

	
  1.               POST-ANALGESIC

  OR SEDATIVE

  AGENT

  	
   

  	
  DOSE

  	
   

  	
  ROUTE

  	
   

  	
  VOLUME

  	
   

  	
  FREQUENCY

  OF DOSING

  	
   

  	
  DURATION OF

  TREATMENT

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  N/A

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
     

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  

 

2.                         ANESTHESIA
MONITORING (check all techniques that will be used for assessing adequate
anesthesia level. Also indicate the frequency of monitoring.

	
  o

  	
   

  	
  Response to toe/skin pinch - frequency:

  
	
  o

  	
   

  	
  Palpebral/corneal reflex - frequency:

  
	
  o

  	
   

  	
  Assessment of jaw and/or skeletal muscle tone -
  frequency:

  
	
  o

  	
   

  	
  Monitoring of physiological response:

  
	
   

  	
   

  	
  Instrumentation
  for heart rate monitoring: (Name device)

  
	
   

  	
   

  	
  Instrumentation
  for blood pressure monitoring: (Name device.)

  
	
   

  	
   

  	
  o    Other: Explain:

  

 

E.                         EUTHANASIA

1.                        METHOD OF
EUTHANASIA (See recommended methods of euthanasia in the appendices.)

o                     Overdose of anesthetic:

	
  Identify Anesthetic

  	
   

  	
  Approximate Amount

  	
   

  	
  Route

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
     

  	
   

  	
   

  	
   

  	
   

  	
   

  

 

o                     Cervical dislocation with
anesthesia or sedation:

	
  Identify Anesthetic

  	
   

  	
  Approximate Amount

  	
   

  	
  Route

  	
   

  
	
  

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
     

  	
   

  	
   

  	
   

  	
   

  	
   

  

 

o                     Cervical dislocation without
anesthesia or sedation:

o                     Exsanguination under anesthesia or
sedation:

	
  Identify Anesthetic

  	
   

  	
  Approximate Amount

  	
   

  	
  Route

  	
   

  
	
  

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
     

  	
   

  	
   

  	
   

  	
   

  	
   

  

 

x                   CO2 chamber

o                     Other:

o                     If the animals are not euthanized
at the END of the study, what will happen to them?

 4
 

2.                        STUDY END
POINT FOR ANIMALS (SELECT ALL THAT APPLY):

Experimental endpoint criteria must be specified.

	
  o

  	
   

  	
  Euthanized per protocol without treatment or
  experimentation.

  
	
  o

  	
   

  	
  Euthanized per protocol after defined period of
  time (days/months)

  
	
   

  	
   

  	
  Define
  period:

  

x                   Euthanized per protocol after
completion of the experimental protocol.

	
  o

  	
   

  	
  Euthanized per protocol at development of
  specific signs.

  
	
   

  	
   

  	
  Explain:

  
	
  o

  	
   

  	
  Euthanized per protocol when moribund.

  
	
  o

  	
   

  	
  The animal may die as a result of the
  experimental treatment.

  
	
   

  	
   

  	
  Explain
  why this is necessary:

  

 

F.                         RESTRAINT
/ DEPRIVATION

1.                         RESTRAINTS:
Describe any proposed restraint (other than short-term hand-held restraint)
to be used on awake animals.

x NO - Prolonged
restraint will not be used.

o YES - Prolonged restraint will be used.

a.                          Justification:

b.                          Description:

c.                          Duration:
State the duration of the restraint including the length, frequency and
rest periods between restraint periods

d.                          Conditioning
and monitoring: Describe steps to be taken to condition the animals to the
restraining device and assure the comfort and well being of the animals.

2.                         DEPRIVATION
(Food or water restriction)

o NO - Food or water deprivation will not
take place.

x YES - Food or water deprivation will take
place.

e.                          Justification:                                 in
order for the animals to adopt proper behavior in the lickometers a motivation
is needed. The motivation in this case is thirst. The motivation is not
possible without the deprivation.

f.                            Description:   Mice will be water deprived
ON (~15 hours) prior to the initial test session of the week. The first session
will allow mice to learn that water is available to them through the sipper
tube by exposing the animal to the open sipper tube containing distilled water
for 20 minutes.

g.                         Duration:
24 hour before study

h.                         Conditioning
and monitoring: The animals will be monitored for signs of dehydration,

 5
 

such as weight loss. Mice losing more then 20% of body
weight will be removed from the study.

G.                       PAIN/DISTRESS

1.                         CATEGORY OF RESEARCH: The investigator
should check the appropriate category(ies) of experimentation and the number of
animals used in each.

x                   A: Number of animals:    120     

The research involves either no pain
or potentially involves momentary, slight pain, discomfort or distress,
includes simple invasive procedures (e.g., injection, blood sampling),
collection of tissues preceded by standard euthanasia, behavioral testing
without stress.

o                     B: Number of animals:         

The research potentially involves
minor short-term pain, discomfort or distress which will be treated with
appropriate anesthetics/analgesics. Includes terminal anesthetic surgery, minor
survival surgery with anesthesia and without significant postoperative pain
(e.g., biopsy) and/or implantation of minor chronic catheters (e.g., femoral
arterial and venous catheters, flow probes, etc.) and/or short-term physical
restraint (<60 minutes) of awake animals and/or induction of minor
behavioral stress.

o                     C: Number of animals:         

The research involves procedures
potentially inducing moderate pain, discomfort or distress which will be treated
with appropriate anesthetics/analgesics and/or chronic maintenance of animals
with a disease/functional deficit, includes major survival surgery with
anesthesia (e.g., orthopedic surgery on major skeletal components, bowel
resection, cardiac surgery, adrenalectomy) and/or inducement of a functional
deficit (e.g., non-painful tumor inducement, inflammation induced by adjuvants,
inducement of glaucoma, heart failure inducement), and/or physical restraint
(>60 minutes) of awake animals and/or induction of more than minor
behavioral stress.

o                     D: Number of animals:         

The research potentially involves
pain, discomfort or distress (greater than that attending routine injection)
which cannot/will not be alleviated through the administration of appropriate
anesthetic, analgesic or tranquilizer drugs. Examples include pain research,
radiation testing, toxicity testing and carcinogenesis experiments where
animals become moribund.

In order for a protocol to qualify as
category A, B or C, appropriate anesthetics or analgesics must be used if the
animal will experience more than momentary slight pain. Momentary slight pain
is defined as pain no greater than the level and duration of pain attending a
routine injection. Alternately, the animal must be immediately euthanized upon
evidence of such pain or the protocol is classified as category D.

H.                       REGULATORY
QUESTIONS

1.                         THE
ANIMAL WELFARE ACT’S “DUPLICATE EXPERIMENTS” QUESTION

a.                          Describe
the methods that were used to assure the Animal Care Committee that the animal
activities in this protocol do not unnecessarily duplicate previous
experiments.

Medline search describes similar methos but the use of
novel compounds and the direct application of these methods for taste research
is novel. Search was conducted on 08/29/05

 6
 

b.                         Indicate
resources / scientific literature used:

	
  x

  	
   

  	
  MEDLINE

  	
   

  	
  (inclusive dates  Nov 1980 -August
  2005  )

  
	
  o

  	
   

  	
  INDEX MEDICUS

  	
   

  	
  (inclusive dates                    )

  
	
  o

  	
   

  	
  AGRICOLA

  	
   

  	
  (inclusive dates                    )

  
	
  o

  	
   

  	
  EMBASE

  	
   

  	
  (inclusive dates                    )

  
	
  o

  	
   

  	
  CURRENT RESEARCH INFORMATION
  SERVICE  (inclusive
  dates                    )

  
	
  o

  	
   

  	
  Animal Welfare Information Center
  (see appendices)

  
	
  o

  	
   

  	
  Peer review by:

  
	
  o

  	
   

  	
  Consultation with an expert in the
  area of investigation (briefly describe; name, position, etc.

  
	
  o

  	
   

  	
  Other:

  

c.                         Key words
used in the search for alternatives:    Lickometer, mice, taste
testing

2.                         THE
ANIMAL WELFARE ACT’S “ALTERNATIVE” QUESTION

ALTERNATIVES TO POTENTIALLY PAINFUL PROCEDURES:

a.                         Describe
the methods that were used to assure the ACC that the Principal Investigator
considered alternatives to procedures that may cause more than momentary or
slight pain or distress to the animals. Provide a written narrative description
of the methods and resources.                   No
painful methods are being used

 

 

b.                         Indicate
resources / scientific literature used:

	
  o

  	
   

  	
  MEDLINE

  	
   

  	
  (inclusive dates                    )

  
	
  o

  	
   

  	
  INDEX MEDICUS

  	
   

  	
  (inclusive dates                    )

  
	
  o

  	
   

  	
  AGRICOLA

  	
   

  	
  (inclusive dates                    )

  
	
  o

  	
   

  	
  EMBASE

  	
   

  	
  (inclusive dates                    )

  
	
  o

  	
   

  	
  CURRENT RESEARCH INFORMATION
  SERVICE (inclusive dates                    )

  
	
  o

  	
   

  	
  Animal Welfare Information Center (see appendices)

  
	
  o

  	
   

  	
  Peer review by:

  
	
  o

  	
   

  	
  Consultation with an expert in the
  area of investigation (briefly describe; name, position, etc.

  
	
  o

  	
   

  	
  Other:

  

 

c.                         Keywords
used in the search for alternatives.:

 7
 

I.                            OTHER

1.                         Do any of
the proposed procedures involve the use of Biohazardous materials?

x                        NO - BIOHAZARDOUS materials will not be used in
or disposed of by CAF.

o                          YES - BIOHAZARDOUS materials will be used. (“Application
for the Use of Biohazardous

    Materials and Animals” must be submitted with the
Animal Use Protocol):

o                          Laser Use (Laser Task Force)

o                       Radioisotopes (Radiation Safety Committee)

o                       Carcinogens, Teratogens, Mutagens, Chemicals

o                       Transmissible/Infectious Agents/Organisms

o                       Recombinant DNA

o                       Other:

2.                         Will
tumor cells, tissue, sera or other biologies from either animal or human
sources be used in or on animal as part of the protocol?

x                     NO

o                       YES

a.                         Please
describe precautions that should be observed with materials or with live/dead
animals.

b.                        Describe
the tests used to check the tissues and cells for inadvertent contamination by
viruses or mycoplasma.

3.                         ANTIBODY
PRODUCTION

o                     Polyclonal antibodies:

o                     Monoclonal antibodies:

o                      Adjuvants used.

Adjuvant                       
(If Freund’s Complete Adjuvant is used, See ACC guidelines)

Route of administration:

Amount injected:

Site preparation:

4.                         TRANSGENIC
MICE

Will
transgenic mice be used?

o                     NO

o                     YES                                              Source:
                     

Health status: (Describe the tests used to check the
animals for inadvertent contamination by viruses or mycoplasma.)

5.                         Will
animals be transported to or through patient care areas? (This includes
hallways in Korman Research Pavilion.)

x                    NO

o                      YES                                              Identify:

Need:

Measures used to protect patients and hospital staff
from possible allergic or emotional reactions:

Describe route and methods used to move/hide animals
from view:

 8
 

6.                         Will
there be a need to house animals outside of the animal facility for more than
12 hours?

x                    NO

o                      YES           Room Number                
Building                

Please provide justification:

Describe precautions used to prevent contamination of
the area by the animals (e.g., smells, dander) and procedures to assure that
the animals are maintained in a humane manner.

J.                         PERSONNEL
QUALIFICATIONS / INFORMATION

Attach forms:

	
  Principal Investigator Qualifications in Animal
  Care and Use

  	
   

  	
  Attached: x

  
	
  Support
  Personnel Qualifications in Animal Care and Use

  	
   

  	
  Attached: x

  

 

Do you foresee any potential safety concerns beyond
the normal possibility of animal bites, animal scratches, zoonoses, and
allergens when accomplishing this protocol?

x                    NO

o                      YES

What are those concerns and what precautions will be
taken?

K.                       ASSURANCE
STATEMENTS AND SIGNATURES

“I accept and will conform to all federal and state laws and guidelines
and all institutional policies and procedures concerning the care and use of
animals in research, teaching, and testing. I understand that I have a
responsibility to notify the Animal Care Committee in writing of any
substantive changes in the proposed project, changes in personnel assigned to
work under this application, or in the number of animals or the species to be
used, prior to proceeding with any animal use in such modified projects.

	
  /s/ Illegible

  	
   

  
	
  Signature of Principal Investigator:

  

 

The information provided in the Animal Use Protocol form accurately
reflects the nature of the activities proposed.

	
  /s/ Illegible

  	
  9/26/05

  
	
  Signature of Department Chair

  

 

 9
 

Only one copy of this
page should submitted to the ACC committee coordinator. This funding source
information should not be included in the copies for distribution to the ACC.

L.                        FUNDING
SOURCES:

1.                         EXTERNAL
FUNDING

a.                         Please
provide name of the source Linguagen Corporation

It is important that researchers who are applying for
PHS funds read Pages 17-18, “Vertebrate Animals”, of the grant application
package and complete Section 2F. You may call the ORTD office at 456-7217 if
you have questions or need additional information.

b.                         Grant
Title:

c.                         Amount of
grant or contract:

d.                         Does the
award Include administrative

o                     NO

o                     YES, please
give dollar amount:

e.                         Does the
agency to which you are applying for fund require an institution approved
animal use protocol?

o                     NO

o                     YES

2.                         INTERNAL
FUNDING

x                   NO

o                     YES:

o           Department:

o           AESG:

o           Other

Most, but not all, granting agencies allow to apply for a grant before
the animal use protocol has been approved. If your protocol has been submitted,
but is not yet approved, indicate to the granting agency that the protocol is “pending”.
NIH and NSF normally allow sixty days for approval after the deadline date for
the grant. If no approval from the ACC follows within sixty days of the
deadline date for the grant application, the agency will normally discard your
grant application.

Some funding agencies (such as American Heart Association) require that
the protocol be approved before the grant is submitted. Investigators are
responsible for knowing the requirements of their particular agency.

 10

EXHIBIT B 

Animal Use Protocol Application Instructions

	
  Albert
  Einstein Healthcare Network

  Animal Care Committee

  ANIMAL USE PROTOCOL APPLICATION INSTRUCTIONS (to be used with the

  application form)

  

 

1.                         Regulating
and Accrediting Agencies

2.                         AEHN
Animal Care Committee Responsibility

3.                         Annual
Review Process

4.                         Guidelines/Instructions
for completing the Animal Use Protocol Application

A.                      ADMINISTRATIVE
INFORMATION

B.                      PROJECT
DESCRIPTION

C.                      ANIMAL
SELECTION

D.                      PRE-ANESTHESIA
/ ANESTHESIA / SEDATIVES / ANALGESICS

E.                        EUTHANASIA

F.                        RESTRAINT
/ DEPRIVATION

G.                      PAIN /
DISTRESS

H.                      REGULATORY
QUESTIONS

I.                           OTHER

J.                        SIGNATURE
STATEMENTS

K.                      PERSONNEL
QUALIFICATIONS / INFORMATION

L.                       FUNDING
(only need to furnish one copy for the Office for Research and Technology

Development)

M.                    APPENDICES

1.                         Regulating
and Accrediting Agencies

A.                       Animal
Welfare Act - Federal regulations under the Animal Welfare Act mandate
registration with the United States Department of Agriculture, Animal and Plant
Health Inspection Service, Regulatory Enforcement and Animal Care, Animal Care
Division. AEHN is registered as a Class “R”, Registered Research Facility and
as such is subject to the Animal Welfare Act regulations including unscheduled
inspections by the United States Department of Agriculture.

B.                       Health
Research Extension Act of 1985 - Under the requirements of the Health
Research Extension Act of 1985, AEHN as a recipient of Public Health Service
funding is registered with the Public Health Service, Department of Health and
Human Services, Office for Protection from Research Risks (OPRR), National
Institutes of Health and is subject to its rules and regulations. As required
by the Public Health Services (PHS), Policy on Humane Care and Use of
Laboratory Animals, AEHN must provide an acceptable written Animal Welfare
Assurance to OPRR. Our Assurance states we will follow the recommendations in
the Guide for the Care and Use of Laboratory
Animals.

C.                       Association
for Assessment and Accreditation of Laboratory Animal Care (AAALAC) - AEHN’s
accreditation provides an independent, rigorous assessment of our Animal Care
and Use Program. Maintenance of AAALAC accreditation is affirmation of the
animal program’s accountability and its efforts to promote ethical practices in
the care in the use of animals. Many granting organizations strongly recommend
an accredited animal program. Government agencies regard AAALAC accreditation
as evidence of program excellence and compliance with all policies and
regulations.

2.                         Albert
Einstein Medical Center Animal Care Committee Responsibility

All research and training involving the use of animals must have an
approved Animal Use Protocol on file with the Office for Research and
Technology Development. Animal Use Protocols are reviewed by an appointed
Animal Care Committee (ACC). The ACC is appointed by the Vice President and
General Director of AEHN as proscribed by the Animal Welfare Act and the PHS
policy. The ACC includes: scientists experienced in animal research,
non-scientists, one member not affiliated with AEMC, and a veterinarian
experienced in laboratory animals.

The ACC is also proscribed by the Animal Welfare Act and the PHS policy
to conduct semi-annual reviews of the Animal Care Program, inspections of the
animal facilities, and animal use areas. The Animal Use Protocols and the
Animal Care Committee minutes are subject to review by United States Department
of Agriculture inspectors, AEHN’s accrediting agency (Association for
Assessment and Accreditation of Laboratory Animal Care) site visitors,
officials from granting agencies (e.g., NIH) and authorized Office for
Protection from Research Risks other Public Health Service (PHS)
representatives. The ACC also investigates reported concerns regarding the
humane care and use of animals at the AEHN.

3.                         Annual
Review Process

Animal Use Protocols that have been approved by the
ACC are reviewed annually. The review process will proceed as follows:

1.                          An
annual review notice and form is sent out to the Principal Investigator
approximately two weeks prior to the protocol anniversary date. The ACC will
request the following: a notice of any substantial changes to the original
protocol, a progress summary, notice of completion, or a reason for not
completing the protocol. The annual review form should be returned within two
weeks. If the annual review form is received within that time and approved by
the Committee, an approval letter is sent to the Investigator. If more
information is required, the Investigator will be notified.

2.                          A
second notice is sent out if the annual review form has not been returned
within two weeks. The due date for this notice is also two weeks.

3.                          Final
notice is sent out with a two week due date. This allows the Investigator a
total of six weeks in which to respond to the request for an annual review.

4.                          If
no response to the final notice is received within two weeks, the protocol is
inactivated and the Investigator is notified. Animals can no longer be ordered
or housed under this protocol. Animals being housed in the Facility under the
inactivated protocol must be disposed of within two weeks.

5.                          A
new protocol form must be submitted if the Investigator decides to resume work
on an inactivated protocol.

6.                          If
you have any questions or concerns, address them to the ACC Coordinator at
215-456-7217.

7.                          After
three years, you will be requested to update your protocol by submitting a new
form. The notification process is the same as the one outlined above.

PI’s who use animals in their laboratories should expect visits by a
subcommittee of the ACC at approximately six month intervals. In addition to
looking at the facilities during the laboratory visits, the ACC members will
observe animal procedures, if in progress, discuss animal use

procedures described in the
applicable protocol(s) with the research staff, inspect drugs and materials
intended for in vivo use, and inspect research animal records

4.                         Guidelines/Instructions
for completing the Animal Use Protocol Application.

1.                          Animal
Use Protocols must be submitted to the Office for Research and Technology
Development (ORTD) for distribution to the members of the ACC. The ACC is
scheduled to meet on the second Monday of the month. Completed Animal Use
Protocol forms must be received by ORTD ten working days prior to the meeting.
The ORTD is located in the Korman Research Pavilion, Room 100 (ext. 6-7217).
The ACC Coordinator serves as the point of contact for information regarding
the ACC.

2.                          The Animal Use Protocol form must be typed.
Submit eight copies of the completed Animal Use Protocol. Please make sure
all abbreviations are clarified. The application is available on diskette.

3.                          It
will be necessary for the Principal Investigator or an appropriate substitute
to attend the ACC meeting to present a brief summary and to clarify points in
the Animal Use Protocol.

4.                          Separate
Animal Use Protocol forms must be completed for each animal use procedure and
for each species.

5.                          The
Animal Welfare Act requires the ACC to verify the qualifications of those who
are involved in the animal use of the research. To fulfill this responsibility
the Animal Care Committee asks that a record of animal use experience,
training, and intended training of all personnel be included with each Animal
Use Protocol. Please use the following forms and attach them to the protocol:

Principal
Investigator Qualifications in Animal Care and Use form 

Support Personnel Qualifications in
Animal Care and Use form

6.                          The
institutional attending veterinarian and the AEMC’s Central Animal Facility
staff (ext. .6-7159) will assist investigators in completing the Animal Use
Protocol forms, train personnel, and conduct procedures described in the
protocol.

7.                          Investigators
needing to make modifications (e.g., small increases in number of animals,
change of anesthesia, adding personnel) to their approved Animal Use Protocol
can submit a brief addendum to the ACC. Please use the Request to Modify an Approved Animal Use Protocol form.

8.                          The
Animal Care Committee will send written notice of approval, approval with
modifications, disapproval or disapproval with suggestions to allow approval.
An ACC approved Animal Use Protocol will be assigned a number. Animals can not
be used without an approved Animal Use Protocol.

A.                       Administrative
Information

1.                                                            INDICATE YOUR
SELECTION BY CHECKING ALL THAT ARE APPROPRIATE.

o                      New: The
research or training protocol has not been reviewed and/or approved previously.

o                      Renewal: This
research or training protocol was approved previously by ACC, but is
approaching the end of its 3 year approval period. Provide the previously
approved Animal Protocol Use number.

o                      Revision: A
resubmitted modified tabled protocol.

o                      Pilot Study:

o                       Other:

2.                         PROTOCOL
TITLE: Self-explanatory.

3.                         PRINCIPAL
INVESTIGATOR(S): The person with overall responsibility for the animal care
and use activities, the personnel involved with the animal procedures and
charges incurred by the animal facility.

4.                         PHONE: Self-explanatory.

5.                         BEEPER: Self-explanatory.

6.                         E-MAIL: Self-explanatory.

7.                         DEPARTMENT/LOCATION:
Self-explanatory.

8.                         DEPARTMENT
CHAIRPERSON: Self-explanatory

9.                         TECHNICIAN(S)/CO-INVESTIGATOR(S)
DEPT.(S)                                                                  TITLE(S)
                                                   PHONE

List all personnel involved in the live  animal-related activities of the
protocol. Also complete a “Qualifications in

   Animal Care and Use” form for each individual
listed.

10.                  CONTACT PERSON
(S) FOR AFTER NORMAL WORKING HOURS: List name(s) to contact in the event
there is a need to reach a protocol participant for animal care problems that
occur after normal working hours or when the Principal Investigator is not
available.

B.                       PROJECT
DESCRIPTION

1.                         START
DATE: Self-explanatory

2.                         FINISH
DATE: Self-explanatory - An approved Animal Use Protocol has a three year
life.

3.                         PURPOSE: What
are the specific scientific objectives (aims) of the research?

4.                         ABSTRACT:
The abstract should state the purpose of the study, objectives, and
describe the basic procedures or techniques. The abstract should be written in
terms understandable by a non-scientist.

5.                         LAYMAN’S
PARAGRAPH: Give a brief overview of the protocol including potential value
to human and animal health, the advancement of science, or the good of society.
The overview must be in terms that nonscientists and lay members of the
committee can understand.

6.                         DESCRIBE
METHODS AND PROCEDURES SPECIFIC TO THE ANIMAL USE IN THE PROTOCOL: (The
methods section should be written in terms understandable by a non-scientist.)

Specifically address the following
that apply to your project:

o                       Injections: (Describe the routes, amounts,
site preparation)

o                       Special diets, food, or water treatments: (Describe  the diet or water treatment, any
anticipated nutritional deficit, and special housing needs.)

o                       Blood
sampling: (Describe the techniques, volumes, frequency, and anesthesia.)
(see appendices)

o                       Invasive sampling of urine/feces: (Describe
the techniques, volumes, frequency, anesthesia.)

o                       Collection of tissues: (Describe the method
of collection and anesthesia.)

o                       Non-survival surgery: (Describe the
procedure, duration, and anesthesia)

o                       Single survival surgery: (Describe the
procedure, duration, anesthesia, and postoperative care provisions) - Aseptic
techniques must be used on most animals, including rabbits, that undergo major
survival surgery. This technique includes wearing of sterile surgical gloves,
gowns, caps, face masks; use of sterile instruments; and aseptic preparation of
surgical field. Details of the procedure should include how

instruments and materials are sterilized. Survival
surgery on rodents does not require a special facility but should be performed
using sterile instruments, surgical gloves, and aseptic procedure to prevent
clinical infections. Include: the frequency of observations during anesthetic
recovery, frequency of examinations, support therapy, criteria used to assess
pain (see appendices), and administration of pain relieving drugs.

o                      Multiple
survival surgeries involving an individual animal: (Describe the
procedures, duration, anesthesia, postoperative care, provisions for each
procedure; explain how surgeries are related.)

o                      Indwelling
catheters or implants: (Describe the site(s), type(s), and
maintenance/monitoring procedures.)

o                      Administration of drugs/reagents/cells/etc.
(Describe the agent, route of administration and frequency, anesthesia,
anticipated side effects, and monitoring procedures.)

o                      Antibody production: (Indicate the route of
administration, adjuvant use, frequency, and collection procedures.)

o                      Tumor transplantation: (Describe any
anticipated functional deficit to the animal, monitoring protocol and,
endpoints used.)

o                      Toxicity
testing: (Describe the procedure, anticipated side effects, and endpoint)

o                      Behavioral testing without significant restraint or
noxious stimuli: (Describe.)

o                      Behavioral
testing with significant restraint or noxious stimuli: (Describe testing
and provide rationale for degree of restraint or stimulus.)

o                      Procedures involving potential pain where
pain-relieving methods will not be used: (Completely
describe procedures.)

o                      Human safety
concerns or hazards: (Describe the intended use of materials which may have
possible hazards and means available to ensure the safety.)

o                      Paralytic Agents: Neuromuscular blocking
agents create a significant animal welfare concern since paralyzed animals are
difficult to monitor for anesthetic effectiveness. Scientific justification for
the use of paralytic agents must be documented. (Describe steps taken to assure
that the animal is under anesthesia or analgesic. List the agent used, dose,
route, and frequency.)

o                      Anticipated animal health changes: (Describe
possible health changes, methods to monitor changes, and contingencies for
dealing with the changes or complications. State the criteria for removing
animals from the study. See appendices: 4,5,6)

o                      Special husbandry: instructions or
considerations

C.                       ANIMAL
SELECTION

1.              SPECIES: (mouse,
rat, rabbit, dog, pig, etc.)

2.              STRAIN: (for
rodents and rabbits)

3.              SEX: (male,
female, or either)

4.              AGE AND/OR WEIGHT
RANGE:

5.              SOURCE: Name of
the vendor(s) supplying the animals.

Approved Vendor list on
file in the Central Animal Facility (x7159)

PLEASE JUSTIFY THE SELECTION OF A
VENDOR NOT ON THE LIST:.

6.              JUSTIFY THE USE OF
LIVING ANIMALS: Consider the following:

·                  The complexity
of the processes being study cannot be duplicated or modeled in simpler
systems.

·                            There
is not enough information known about the processes being studied to design
non-living models.

·                            Preclinical
studies or training in living animals are necessary prior to human testing or
use.

1.                         JUSTIFY
THE APPROPRIATENESS OF THE SPECIES SELECTED FOR THE STUDY:

What anatomical,
physiological, or other characteristics/factors did you use to select the
species in consideration of the scientific objectives of the research? Consider
the following:

·                            There
exists an immense amount of data for this species allowing comparison ....

·                            The
anatomy or physiology of this species is uniquely suited to the study because
.....

·                            This
species provides a good model for duplicating the human ....

·                            This
species is the phylogentically lowest that provides adequate size, tissue, or
anatomy for the proposed study.

1.                         TOTAL
NUMBER OF ANIMALS TO BE USED IN THIS PROTOCOL:

Estimate the total number of animals needed over the three year life of
the protocol. An account of the number of the animals ordered will be
maintained by the Central Animal Facility. To exceed the approved number, a “Request to Modify an Animal Use Protocol” must
be submitted to the ACC.

9.                         RATIONALE
FOR DETERMINING THE NUMBER OF ANIMALS NEEDED:

Investigators need to provide a clear and logical
thought process that explains why they have selected the specific number of
animals that they show on their protocol. Additionally, the investigator must
show that the number is a reasonable minimum for
the scientific goals of the study. Please do not copy the statements below. The
goal is not for investigators to have a “blanket” statement, acceptable for all
situations. The goal is for investigators to clearly communicate to the ACC
their own rationale for choosing particular numbers.

Example
statements:

“We will use 4 groups of twenty animals each. Group 1
will have x and drug A. Group 2 will have x and drug B. Group 3 will have x and
both drugs. Group 4 will be controls (no x and no drugs). Data will be compared
using a Student’s “T” test. From previous experiments, we estimate that twenty
will be an adequate group size to show significant results.”

“This is a preliminary study to develop and show the
feasibility of a new surgical technique. We estimate that it may require as
many as twenty animals for us to refine our skills technique adequately to give
the  technique a fair evaluation.”

“This study involves a very small number of animals
(6-10). The variance that will be associated with this data is unknown. The
small number of animals used in this study will provide us with an estimate of
the range and variance of this data.”

“Based on the PI’s experience using these methods in
similar studies, and reviews of related use in peer reviewed published studies,
the number of animals requested is the minimum necessary to meet the scientific
objectives of the proposed research and to provide scientifically meaningful
data.”

D.                       PRE-ANESTHESIA
/ ANESTHESIA / SEDATIVES / ANALGESICS

1.                         If
Sedation, analgesics, tranquilizers, and /or anesthesia is (are) used, please
identify.

(See Appendices for suggested methods). Also, the attending
vet is available for consultation, x7217.

2.                         ANESTHESIA
MONITORING (check all techniques that will be used for assessing adequate
anesthesia level. Also indicate the frequency of monitoring.

o                      Response to toe/skin pinch - frequency:

o                      Palpebral/corneal reflex - frequency:

o                      Assessment of jaw and/or skeletal muscle tone -
frequency:

o                      Monitoring of physiological response:

Instrumentation for heart rate monitoring: (Name device)

Instrumentation for blood pressure monitoring: (Name device.)

o                      Other: Explain:

E.                         EUTHANASIA

Euthanasia means the humane destruction of an animal accomplished by a
method that provides rapid unconsciousness and subsequent death without
evidence of pain or distress, or a method that utilizes anesthesia produced by
an agent that causes painless loss of consciousness and subsequent death.

The Animal Care Committee follows the guidelines established by the
American Veterinary Medical Association Panel (AVMA). Suggested methods are
included in the appendicies. The complete text from the AVMA Panel is available
from the CAP (extension x7159)

1.                        METHOD OF
EUTHANASIA (See recommended methods of euthanasia in the appendices.)

o                       Overdose
of anesthetic:

	
  Identify Anesthetic

  	
   

  	
  Approximate

  Amount

  	
   

  	
  Route

  	
   

  
	
     

  	
   

  	
   

  	
   

  	
   

  	
   

  

 

o                       Cervical
dislocation with anesthesia or sedation:

	
  Identify Anesthetic

  	
   

  	
  Approximate

  Amount

  	
   

  	
  Route

  	
   

  
	
     

  	
   

  	
   

  	
   

  	
   

  	
   

  

 

o                       Cervical
dislocation without anesthesia or sedation:

Justify the reason for not using
anesthesia of sedation: The AVMA states “until additional
information is available to better define the nature of the persistent EEG
activity, this technique should be used in research settings only when
scientifically justified by the user and approved by” the ACC.

o                       Exsanguination
under anesthesia or sedation:

	
  Identify Anesthetic

  	
   

  	
  Approximate

  Amount

  	
   

  	
  Route

  	
   

  
	
     

  	
   

  	
   

  	
   

  	
   

  	
   

  

 

o                       CO2 chamber

o                       Other:

o                       If the animals are not euthanized at the of the study, what will happen
to them?

2.                        STUDY END
POINT FOR ANIMALS (SELECT ALL THAT APPLY):

Experimental endpoint criteria must be specified.

o                       Euthanized per protocol without treatment or
experimentation.

o                       Euthanized per protocol after defined period of time
(days/months)

Define
period:

o                       Euthanized per protocol after completion of the
experimental protocol.

o                       Euthanized per protocol at development of specific
signs.

Explain:
(see appendices for examples of endpoint criteria)

o                       Euthanized per protocol when moribund.

o                       The animal may die as a result of the experimental
treatment.

Explain why this is necessary:

F.                                                           RESTRAINT
/ DEPRIVATION

1.                                                           RESTRAINTS:. Describe
any proposed restraint (other than short-term, hand-held restraint) to be used
on awake animals. Note: Physical restraint procedures should be used on awake
animals only after alternative procedures have been considered and found to be
inadequate. If restraint is necessary, the device must provide the animal with
the greatest opportunity to assume its normal postural adjustments, and the
duration of restraint must be minimized.

o                       NO -
Prolong restraint will not be used.

o                       YES -
Prolong restraint will be used.

a.                         Justification:
Justify the need for restraint.

b.                         Description:
Identify or describe the restraint device.

c.                         Duration:
State the duration of the restraint including the length, frequency, and rest
periods between restraint periods

d.                         Conditioning
and monitoring: Describe steps to be taken to condition the animals to the
restraining device and assure the comfort and well being of the animals.

2.                         DEPRIVATION
(Food or water restriction)

o                       NO - Food or water deprivation will not take
place.

o                       YES - Food or water deprivation will take place.

a.                         Justification:

b.                         Description:

c.                         Duration:

d.                         Conditioning
and monitoring:

G.                                                          PAIN / DISTRESS

1.                          CATEGORY OF RESEARCH: The investigator
should check the appropriate category(ies) of experimentation and the number of
animals used in each.

o                      A: Number of animals:

The research involves either no pain
or potentially involves momentary, slight pain, discomfort or distress.
Includes simple invasive procedures (e.g., injection, blood sampling),
collection of tissues preceded by standard euthanasia, behavioral testing
without stress.

o                      B: Number of animals:

The research potentially involves
minor short-term pain, discomfort, or distress which will be treated with
appropriate anesthetics/analgesics. Includes terminal anesthetic surgery, minor
survival surgery with anesthesia, and without significant postoperative pain
(e.g., biopsy) and/or implantation of minor chronic catheters (e.g., femoral
arterial and venous catheters, flow probes, etc.) and/or short-term physical
restraint (<60 minutes) of awake animals and/or induction of minor
behavioral stress.

o                      C: Number of animals:

The research involves procedures
potentially inducing moderate pain, discomfort, or distress which will be
treated with appropriate anesthetics/analgesics and/or chronic maintenance of
animals with a disease/functional deficit. Includes major survival surgery with
anesthesia (e.g., orthopedic surgery on major skeletal components, bowel
resection, cardiac surgery, adrenalectomy) and/or inducement of a functional
deficit (e.g., non-painful tumor inducement, inflammation induced by adjuvants,
inducement of glaucoma, heart failure inducement), and/or physical restraint
(>60 minutes) of awake animals and/or induction of more than minor behavioral
stress.

o                      D: Number of animals:

The research potentially involves
pain, discomfort, or distress (greater than that attending routine injection)
which cannot/will not be alleviated through the administration of appropriate
anesthetic, analgesic or tranquilizer drugs. Examples include: pain research,
radiation testing, toxicity testing and carcinogenesis experiments where
animals become moribund.

In order for a protocol to qualify as
category A, B or C, appropriate anesthetics or analgesics must be used if the
animal will experience more than momentary slight pain. Momentary slight pain
is defined as pain no greater than the level and duration of pain attending a
routine injection. Alternately, the animal must be immediately euthanized upon
evidence of such pain or the protocol is classified as category D.

H.                                                         REGULATORY
QUESTIONS

1.                         THE
ANIMAL WELFARE ACT’S “DUPLICATE EXPERIMENTS” QUESTION

According to the Animal Welfare Act, the ACC is required to determine
whether a reasonable good faith effort was made by the principal investigator
in determining that a proposed experiment is not duplicative. The ACC will be
held responsible if it is subsequently determined that an experiment is
unnecessarily duplicative and that a good faith review of available sources would
have indicated as much.

a.                         Describe
the methods that were used to assure the Animal Care Committee that the animal
activities in this protocol do not unnecessarily duplicate previous
experiments.

b.                         Indicate
resources / scientific literature used:

	
  o

  	
   

  	
  MEDLINE

  	
  (inclusive dates)

  
	
  o

  	
   

  	
  INDEX MEDICUS

  	
  (inclusive dates)

  
	
  o

  	
   

  	
  AGRICOLA

  	
  (inclusive dates)

  
	
  o

  	
   

  	
  EMBASE

  	
  (inclusive dates)

  
	
  o

  	
   

  	
  CURRENT RESEARCH INFORMATION SERVICE

  	
  (inclusive dates)

  
	
  o

  	
   

  	
  Animal Welfare Information Center (see
  appendices)

  
	
  o

  	
   

  	
  Peer review by:

  
	
  o

  	
   

  	
  Consultation
  with an expert in the area of investigation (briefly describe; name,
  position, etc.

  
	
  o

  	
   

  	
  Other:

  
							

c.                         Key words
used in the search for alternatives:

2.                         THE
ANIMAL WELFARE ACT’S “ALTERNATIVE” QUESTION

ALTERNATIVES TO POTENTIALLY PAINFUL PROCEDURES. The use of procedures
potentially causing more than momentary or slight pain or distress to an animal
even though that pain will be relieved by administration of proper drugs,
requires investigators consider alternative procedures and provide a written
description of the methods and sources used to determine that alternatives were
not available and/or were scientifically unacceptable. Note: In designing the
experiment, the investigator should choose procedures that have the least
amount of potential pain, discomfort, distress, or morbidity in consideration
of any limitations imposed by the objectives of the research. Examples include
reduction of the number of required surgeries, less invasive surgery, use of a
less toxic adjuvant, selection of the earliest possible endpoint. This section
should clearly justify why less potentially painful procedures cannot be used
to achieve the specific objectives of the research. This section must also
include a description of the search strategy used to explore alternatives
(e.g., databases consulted, key words used). USDA inspectors require a
description of the key words used in the search of alternatives. Investigators
should be ready to present the results of their searches to the ACC, USDA,  and NIH. USDA inspectors regularly review the
ACC’s records.

a.                         Describe
the methods that were used to assure the ACC that the Principal Investigator
considered alternatives to procedures that may cause more than momentary or
slight pain or distress to the animals. Provide a written narrative description
of the methods and resources.

b.                         Indicate
resources / scientific literature used:

	
  o

  	
   

  	
  MEDLINE

  	
  (inclusive dates)

  
	
  o

  	
   

  	
  INDEX MEDICUS

  	
  (inclusive dates)

  
	
  o

  	
   

  	
  AGRICOLA

  	
  (inclusive dates)

  
	
  o

  	
   

  	
  EMBASE

  	
  (inclusive dates)

  
	
  o

  	
   

  	
  CURRENT RESEARCH INFORMATION SERVICE (inclusive
  dates)

  
	
  o

  	
   

  	
  Animal Welfare Information Center (see
  appendices)

  
	
  o

  	
   

  	
  Peer review by:

  
	
  o

  	
   

  	
  Consultation
  with an expert in the area of investigation (briefly describe; name,
  position, etc.

  
	
  o

  	
   

  	
  Other:

  
						

 

c.                          Keywords
used in the search for alternatives.

I.                            OTHER

1.                         Do any of
the proposed procedures involve the use of Biohazardous materials?

o                      NO - BIOHAZARDOUS materials will not be used in
or disposed of by CAF.

o                      YES - BIOHAZARDOUS materials will be used. (“Application
for the Use of Biohazardous Materials and Animals” must be submitted with the
Animal Use Protocol):

o                      Laser Use (Laser Task Force)

o                      Radioisotopes (Radiation Safety Committee)

o                      Carcinogens, Teratogens, Mutagens, Chemicals

o                      Transmissible/Infectious Agents/Organisms

o                      Recombinant DNA

o                      Other:

2.                         Will
tumor cells, tissue, sera or other biologies from either animal or human
sources be used in or on animal as part of the protocol?

o                       NO

o                       YES:

a.               Please describe
precautions that should be observed with materials or with live/dead animals.

b.              Describe
the tests used to check the tissues and cells for inadvertent contamination by
viruses or mycoplasma.

3.                         ANTIBODY
PRODUCTION

o                      Polyclonal
antibodies:

o                      Monoclonal antibodies:

o                      Adjuvants used.

Adjuvant (If Freund’s
Complete Adjuvant is used, See ACC guidelines)

Route of administration:

Amount injected:

Site preparation:

4.                         TRANSGENIC
MICE

Will
transgenic mice be used?

o                      NO

o                      YES:                                             Source:

Health status: (Describe
the tests used to check the animals for inadvertent contamination by viruses or
mycoplasma.)

5.                         Will
animals be transported to or through patient care areas? (This includes
hallways in Korman Research Pavilion.)

o                       NO

o                       YES:                                          Identify:

Need:

Measures used to protect patients and hospital staff
from possible allergic or emotional
reactions:

Describe route and methods used to move/hide animals
from view:

 

6.                         Will
there be a need to house animals outside of the animal facility for more than
12 hours?

o                       NO

o                       YES                                                Room
Number:                                                          Building:

Please provide justification:

Describe precautions used to prevent contamination of
the area by the animals (e.g., smells, dander) and procedures to assure that
the animals are maintained in a humane manner.

J.                         PERSONNEL
QUALIFICATIONS/INFORMATION

Attach forms:

Principal Investigator Qualifications
in Animal Care and Use

Support Personnel Qualifications in Animal Care and Use

1.                         Occupational
Health

Continuum, Occupational Health Specialists provides occupational health
and workers’ compensation medical services to all
employees at AEHN. If an employee experiences an occupational injury
in the animal facility between the hours of 8:30 AM to 4:30 PM, Monday through
Friday, they are to notify their supervisor or call Occupational Health Office
at 215-456-9061. Arrangements will
be made for the employee be to transported to an Continuum, Employee Health
Office. If an injury occurs after hours they will be treated at the Emergency
Medicine Department. An employee must have an Incident Report with them for
either site. These Incident Reports are available from the CAF office.
Questions regarding this program can be addressed to Ted Feldman, Program
Director for Continuum at 215-533-9424.

Personnel should be instructed to notify their supervisors of potential
or known exposures and of suspected health hazards and illnesses. Employees
experiencing needle sticks or pathogen exposure must seek treatment
immediately.

Personal protective equipment e.g., surgical
masks, exam gloves, isolation gowns, is provided in the animal facility. Also,
along with the animal restrain devices and animal handling gloves, animal
handling videos and training are available through the CAF.

K.                       ASSURANCE
STATEMENTS AND SIGNATURES

“I accept and will conform to all federal and state laws and guidelines
and all institutional policies and procedures concerning the care and use of
animals in research, teaching and testing. I understand that I have a
responsibility to notify the Animal Care Committee in writing of any
substantive changes in the proposed project, changes in personnel assigned to
work under this

application, or in the number of animals or the species to be used,
prior to proceeding with any animal use in such modified projects.

Signature of Principal Investigator and date are required.

The principal investigator ensures that the information provided in the
Animal Use Protocol form accurately reflects the nature of the activities
proposed.

Only one copy of this page
should be submitted to the ACC committee coordinator. This funding source
information should not be included in the copies for distribution to the ACC.

L.                                         FUNDING
SOURCES:

1.                         EXTERNAL
FUNDING

a.                         Please
provide name of the source.

It is important that researchers who are applying for
PHS funds read Pages 17-18, “Vertebrate Animals,” of the grant application
package and complete Section 2F. You may call the ORTD office at 456-7217 if
you have questions or need additional information.

b.                         Grant
Title:

c.                         Amount of
grant or contract:

d.                         Does the
award include administrative

o                       NO

o                       YES, please give dollar amount:

e.                         Does the
agency to which you are applying for fund require an institution approved
animal use protocol?

o                       NO

o                       YES

2.                         INTERNAL
FUNDING

o                       NO

o                       YES:

o            Department:

o            AESG:

o            other

Most, but not all, granting agencies allow to apply for a grant before
the animal use protocol has been approved. If your protocol has been submitted,
but is not yet approved, indicate to the granting agency that the protocol is “pending”.
NIH and NSF normally allow sixty days for approval after the deadline date for
the grant. If no approval from the ACC follows within sixty days of the
deadline date for the grant application, the agency will normally discard your
grant application.

Some funding agencies (such as American Heart Association) require that
the protocol be approved before the grant is submitted. Investigators are
responsible for knowing the requirements of their particular agency.

M.                                      APPENDICES

1.                         Recommended
methods of euthanasia according to species:

	
  Species

  	
   

  	
  Method

  	
   

  	
  Route

  	
   

  	
  Dose

  
	
  Rodents

  	
   

  	
  CO2 asphyxiation

  	
   

  	
  inhalation

  	
   

  	
  until death

  
	
   

  	
   

  	
  cervical dislocation(1)

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  pentobarbital

  	
   

  	
  IV

  	
   

  	
  150 mg/kg

  
	
   

  	
   

  	
  decapitation(1)

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
  exsanguination(2)

  	
   

  	
   

  	
   

  	
   

  
	
  Rabbits

  	
   

  	
  Euthanasia Solution

  	
   

  	
  IV, IC(3)

  	
   

  	
  0.3 ml/kg

  
	
   

  	
   

  	
  pentobarbital

  	
   

  	
  IV, IC(3)

  	
   

  	
  70-100 mg/kg

  
	
  Cats
  and Dogs

  	
   

  	
  Euthanasia Solution

  	
   

  	
  IV

  	
   

  	
  0.3 ml/kg

  
	
   

  	
   

  	
  pentobarbital

  	
   

  	
  IV

  	
   

  	
  75-100 mg/kg

  
	
  Swine

  	
   

  	
  Euthanasia Solution

  	
   

  	
  IV

  	
   

  	
  0.3 ml/kg

  
	
   

  	
   

  	
  pentobarbital

  	
   

  	
  IV

  	
   

  	
  75-100 mg/kg

  

 

(1) Cervical
dislocation and decapitation without anesthesia is used only when anesthetics
would interfere with experimental results. These techniques can be performed
without anesthesia only when scientifically justified by the PI and approved by
the ACC. Cervical dislocation is limited to mice and small rats weighing less
than 200 grams,

(2) Technique
should only be done in sedated, or anesthetized animals.

(3) Animal must be sedated or tranquilized before IC
procedure.

2.                         Anesthesia
recommendations

	
  Species

  	
   

  	
  Drug

  	
   

  	
  Dose

  	
   

  	
  Route

  
	
  Mouse

  	
   

  	
  ketamine/acepromazine

  	
   

  	
   

  	
   

  	
  IM

  
	
  Rat

  	
   

  	
  ketamine/acepromazine

  	
   

  	
   

  	
   

  	
  IM

  
	
   

  	
   

  	
  ketamine/xylazine

  	
   

  	
   

  	
   

  	
  IM

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Rabbit

  	
   

  	
  ketamine/xylazine

  	
   

  	
   

  	
   

  	
  IM

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Pig

  	
   

  	
  Telazol/ketamine/xylazine

  	
   

  	
  2.2 mg/kg of each component

  	
   

  	
  IM

  
	
   

  	
   

  	
  Halothane

  	
   

  	
  to effect (2-3%)

  	
   

  	
  inhaled

  
	
   

  	
   

  	
  Isoflurane

  	
   

  	
  to effect(2)

  	
   

  	
  inhaled

  

 

3.                         Analgesic
recommendations

	
  Species

  	
   

  	
  Drug

  	
   

  	
  Dose

  	
   

  	
  Route

  
	
  Mouse

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Rat

  	
   

  	
  Butorphanol tartrate

  	
   

  	
  0.04 mg/kg

  	
   

  	
  SQ

  
	
   

  	
   

  	
  Acetaminophen

  	
   

  	
  110-305 mg/kg [2 mg/ml

  	
   

  	
  PO

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Rabbit

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  
	
  Pig

  	
   

  	
   

  	
   

  	
   

  	
   

  	
   

  

 

4.                         Possible parameters
for evaluation of pain.

·                            Attempting
to protect, move away, or bite

·                            Crying
out when palpated or forced to use affected areas

·                            Licking,
biting, scratching, shaking, or rubbing

·                            Pacing,
lying down and getting up, or shifting weight

·                            Significant
decrease in mobility

·                            Unusual
length of time for recumbency

·                            Reluctance
to move or difficulty in rising

·                            Head
down, tucked abdomen, hunched, facial distortion, or pallor

5.                         Methods
that could be used for monitoring health changes.

·                             Weigh
animals on a regular basis.

·                             Observe
for changes in behavior, activity, or posture.

·                             Observe
for evidence of pain or discomfort in a localized area.

·                             Observe
procedural area for redness, swelling, or discharge.

·                             Observe
for decreased ability to move.

·                             Monitor
food or water consumption

6.                         Endpoint
criteria for removing animals from a study.

·                             Veterinary
opinion

·                             percentage
body weight or loss (example: a loss more than 15% of body weight)

·                             inability
to move

·                             inability
to eat of drink adequately

·                             markedly
reduced response to stimuli

·                             tumor
size

·                             behavioral
abnormalities

·                             signs
of toxicity.

7.                         Animal Welfare Information Center (AWIC) (Your tax dollars at
work.): National Agricultural Library, 10301 Baltimore Blvd., Beltsville, MD
20705, Voice: (301) 504-6212, Fax: (301) 504-5472, Internet:
http://www.nal.usda.gov/awic/. This center can assist investigators in
searching for alternatives and/or perform the search and charge for all online
costs that exceed $25.00.

8.                         Calculation
for the amount of blood you can safely collect from a given animal.

	
  Safe amount of blood volume:

  	
   

  	
  20%

  
	
  Example:

  	
   

  	
   

  
	
   

  	
  4.55 kg

  	
   

  

 

 

	
  weight

  	
  X

  	
  0.06 percent blood volume of body

  
	
   

  	
  0.27 kg

  	
   

  
	
   

  	
  X

  	
  1000.00 mls
  of blood per unit weight

  270.00 mls of blood in the animal

  
	
   

  	
  X

  	
         0.20
  safely take 20% of total blood

  
	
  volume

  	
   

  	
   

  
	
   

  	
   

  	
  54.00 mls can be safely collected

  
				

 

EXHIBIT C

Budget

	
  Principal
  Investigator:

  	
  Heather Kaminski

  
	
  Protocol
  Title:

  	
  Lickometer
  Testing in Mice

  
	
  Company:

  	
  Linguagen

  

 

Research Animals

·                            Linguagen
will purchase all rodents to be used in this protocol.

·                            Linguagen
staff will coordinate animal orders with the CAF staff

·                            Invoices
for animal purchases will be sent directly from the vendors to Linguagen.

Animal Housing and
Care

·                            CAF
will supply standard rodent cages, shelving units, bedding, feed and staff to
provide daily animal care.

·                            CAF
will supply veterinarian services as needed

·                            CAF
staff will prepare (sanitizing and sterilizing) cages for rodent housing.

·                            CAF
will charge $0.79 per cage per day for housed mice.

·                            CAF
will charge $0.97 per cage per day for housed rats.

·                            Estimated
cage count for this budget: 20 to 100 cages per day ($135 to $675 / wk).

·                            CAF
will euthanize and dispose of rodents at Linguagen staff’s request.

Supplies

·                            Linguagen
will provide lab supplies necessary for the procedures described in the
protocol

·                            The
estimate amount is for miscellaneous materials supplied by CAF.

Labor

·                            $12.25
per half hour (non-overtime rate for services other then rodent housing)

·                            The
estimated amount is for possible CAF labor/technician services provided to
Linguagen.

Indirect Costs on the above categories
- 25% (Includes telephone, janitorial service, heating/air conditioning and
electric. All costs associated with the DSL line will be billed directly to
Linguagen.)

Other

·                             Rental
Space

$2.175/month

·                              Cost
per sq. ft. - $25.00 / sq. ft. / year

·                              Total
Space - Approx. l044 sq.ft.

	
  ·                             Lab Space - Room A117
  (Approx. 24’ x 12’)

  	
  288 sq. ft.

  
	
  ·                             Animal
  Housing - Room A114 (Approx. 24’ x 24’)

  	
  576 sq. ft.

  
	
  ·                             Office
  Space - Room A203 (Approx. 10’ x 18’)

  	
  180 sq. ft

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