Document:

401(k) Plan Amendment

 Exhibit 10.33 
 TRIMERIS, INC. EMPLOYEE 401(K) PLAN 
 Amendment 2006-1 Dated December      ,
2006 

 Trimeris, Inc. Employee 401(k) Plan 
  

	 	 ̈	(3)     As a discretionary nonelective contribution. 

  

	 	 ̈	(4)     To reduce nonelective contributions. 

  

	x	(b) Nonelective contribution forfeitures. To the extent attributable to Employer nonelective contributions: (Choose one of (1) through (4))

  

	 	x	(1)     As a discretionary nonelective contribution. 

  

	 	 ̈	(2)     To reduce nonelective contributions. 

  

	 	 ̈	(3)     As a discretionary matching contribution. 

  

	 	 ̈	(4)     To reduce matching contributions. 

  

	 ̈	(c) Reduce administrative expenses. First to reduce the Plan’s ordinary and necessary administrative expenses for the Plan Year and then allocate any remaining
forfeitures in the manner described in Sections 3.05(a) or (b) as applicable. 

 Timing of forfeiture allocation. The Plan
Administrator will allocate forfeitures under Section 3.05 in the Plan Year: (Choose one of(d) or (e)) 
  

	x	(d)     In which the forfeiture occurs. 

  

	 ̈	(e)     Immediately following the Plan Year in which the forfeiture occurs. 

  

	18.	ALLOCATION CONDITIONS (3.06). 

 Allocation conditions.
The Plan does not apply any allocation conditions to deferral contributions, 401(k) safe harbor contributions (under Section 3.01(d)) or to Davis-Bacon contributions (except as the Davis-Bacon contract provides). To receive an allocation of
matching contributions, nonelective contributions, qualified nonelective contributions or Participant forfeitures, a Participant must satisfy the following allocation condition(s): (Choose one or more of (a) through (i) as applicable)

  

	 ̈	(a) Hours of Service condition. The Participant must complete at least the specified number of Hours of Service (not exceeding 1,000) during the Plan Year:
            . 

  

	x	(b) Employment condition. The Participant must be employed by the Employer on the last day of the Plan Year (designate time period). 

  

	 ̈	(c) No allocation conditions. 

  

	 ̈	(d) Elapsed Time Method. The Participant must complete at least the specified number (not exceeding 182) of consecutive calendar days of employment with the Employer
during the Plan Year:             . 

  

	 ̈	(e) Termination of Service/501 Hours of Service coverage rule. The Participant either must be employed by the Employer on the last day of the Plan Year or must complete
at least 501 Hours of Service during the Plan Year. If the Plan uses the Elapsed Time Method of crediting Service, the Participant must complete at least 91 consecutive calendar days of employment with the Employer during the Plan Year.

  

	 ̈	(f) Special allocation conditions for matching contributions. The Participant must complete at least
             Hours of Service during the                      (designate
time period) for the matching contributions made for that time period. 

  

	 ̈	(g) Death, Disability or Normal Retirement Age. Any condition specified in Section 3.06
                     applies if the Participant incurs a Separation from Service during the Plan Year on account of:
                     (e.g., death, Disability or Normal Retirement Age). 

  

	 ̈	(h) Suspension of allocation conditions for coverage. The suspension of allocation conditions of Plan Section 3.06(E) applies to the Plan. 

 

	x	(i) Limited allocation conditions. The Plan does not impose an allocation condition for the following types of contributions: 2006 matching contributions for all
Participants laid off in connection with the Employer’s December 2006 reduction in force. [Note: Any election to limit the Plan’s allocation conditions to certain contributions must be the same for all Participants, be
definitely determinable and not discriminate in favor of Highly Compensated Employees.] 

  

 10 

 Trimeris, Inc. Employee 401(k) Plan 
 Execution Page 
 The Trustee (and Custodian, if applicable), by executing this
Adoption Agreement, accepts its position and agrees to all of the obligations, responsibilities and duties imposed upon the Trustee (or Custodian) under the Prototype Plan and Trust. The Employer hereby agrees to the provisions of this Plan and
Trust, and in witness of its agreement, the Employer by its duly authorized officers, has executed this Adoption Agreement, and the Trustee (and Custodian, if applicable) has signified its acceptance, on: December 3, 2006. 
  

			
	
	Name of Employer: Trimeris, Inc.
	
	Employer’s EIN: 56-1808663
		
	Signed:	 	/s/ Dani Bolognesi
		
		 	Dani Bolognesi / CEO & CSO
		 	[Name/Title]
	Name(s) of Trustee:
		
		 	Prudential Trust Company
		
		 	  
		
		 	  
		
		 	  
		
		 	  
	
	Trust EIN (Optional):
		 	        n/a
		
	Signed:	 	  
		
		 	  
		 	[Name/Title]
	Signed:	 	  
		
		 	  
		 	[Name/Title]
	Signed:	 	  
		
		 	  
		 	[Name/Title]
	Signed:	 	  
		
		 	  
		 	[Name/Title]
	Signed:	 	  
		
		 	  
		 	[Name/Title]
	
	Name of Custodian (Optional):
		 	        n/a
		
	Signed:	 	  
		
		 	  
		 	[Name/Title]

 31. Plan Number. The 3-digit plan number the Employer assigns to this Plan for ERISA reporting
purposes (Form 5500 Series) is: 001. 
 Use of Adoption Agreement. Failure to complete properly the elections in this Adoption Agreement may
result in disqualification of the Employer’s Plan. The Employer only may use this Adoption Agreement in conjunction with the basic plan document referenced by its document number on Adoption Agreement page one. 
 Execution for Page Substitution Amendment Only. If this paragraph is completed, this Execution Page documents an amendment to Adoption Agreement
Section(s) 18i effective December 1, 2006, by substitute Adoption Agreement page number(s) 10. 
 Prototype Plan Sponsor. The Prototype Plan
Sponsor identified on the first page of the basic plan document will notify all adopting employers of any amendment of this Prototype Plan or of any abandonment or discontinuance by the Prototype Plan Sponsor of its maintenance of this Prototype
Plan. For inquiries regarding the adoption of the Prototype Plan, the Prototype Plan 
  

 17 

 Trimeris, Inc. Employee 401(k) Plan 
 Sponsor’s intended meaning of any Plan provisions or the effect of the opinion letter issued to the Prototype Plan Sponsor, please contact the Prototype Plan Sponsor at the following address and telephone number:
P.O. Box 10096, Raleigh NC 27605, 919.783.6400. 
 Reliance on Sponsor Opinion Letter. The Prototype Plan Sponsor has obtained from the IRS an opinion
letter specifying the form of this Adoption Agreement and the basic plan document satisfy, as of the date of the opinion letter, Code §401. An adopting Employer may rely on the Prototype Sponsor’s IRS opinion letter only to the
extent provided in Announcement 2001-77, 2001-30 I.R.B. The Employer may not rely on the opinion letter in certain other circumstances or with respect to certain qualification requirements, which are specified in the opinion letter and in
Announcement 2001-77. In order to have reliance in such circumstances or with respect to such qualification requirements, the Employer must apply for a determination letter to Employee Plans Determinations of the Internal Revenue Service.

  

 18Letter of Agreement

 Exhibit 10.37 
 [LETTERHEAD OF ROCHE PHARMACEUTICALS] 
 Dr. Dani Bolognesi 
 Trimeris, Inc. 
 3500 Paramount Parkway 
 Morrisville, NC 27560 
 U.S.A. 
 Basel, 13 March 2007 
 Re: Roche/Trimeris Research Agreement dated
January 1, 2000 (as amended) 
 Dear Dani: 
 Roche elects
to Opt Out pursuant to Article 5 of the Third Amendment to the Research Agreement and Accord. Accordingly, the rights and obligations set forth in Article 5(a) through (e) are activated. In addition, Trimeris will have the right to develop and
commercialize TRI-1144 as it chooses. Trimeris will pay to Roche a royalty of one percent (1%) of Net Sales of all products containing TRI-1144 in every country in which Trimeris owns an unexpired patent that claims the making, using, selling,
offering for sale, or importing of TRI-1144, up to an aggregated total on royalties set at twenty-four million dollars (US$24,000,000). 
 Pursuant to
Paragraph 5 of the Third Amendment to the Research Agreement and Accord, Roche retains its right to develop up to five (5) Penzberg peptides subject to Trimeris’ right to co-develop any such peptide accepted by Roche into development
before December 31, 2008. 
 Roche and Trimeris will share all costs associated with the TRI-1144 joint research program for 2007, through the date of
execution of this letter. 
 This letter is being provided in duplicate originals. If Trimeris agrees with the above paragraph, please sign and return one
original. 
  

	
	Best regards,
	
	 /s/ William M. Burns

	William M. Burns
	
	Agreed and Accepted:
	
	Trimeris, Inc.
	
	 /s/ Dani P. Bolognesi

	Dani P. Bolognesi, Ph.D., Chief Executive OfficerNON-QUALIFIED STOCK OPTION AGREEMENT

 Exhibit 10.29 
 Employee 
 You have been
granted a Non-Qualified Stock Option to purchase [number of options granted] shares of Common Stock of the Company, subject to the terms and conditions (i) in the Company’s 2000 Stock Incentive Plan, as amended from time to time (the
“Plan”), and (ii) as set forth in Exhibit A, attached hereto and made a parthereof (together with this letter, the “Agreement”), as follows: 
  

			
	 Date of Agreement/ Grant:
	 	[grant date]
	 Non-Qualified Stock Options Granted:
	 	[number of options granted]
		
	 Exercise Price Per Share:
	 	[fair market value on grant date]
	 Total Exercise Price
	 	[number of options granted multiplied by exercise price]
	 Expiration Date:
	 	[to be determined]
	 Vesting Schedule:
	 	25% per year for 4 years

 Please indicate your acceptance by executing two (2) original copies of this Agreement and
returning one (1) original copy by U.S. Mail to Cindy Freeze. 
 Very truly yours, 
 Martin L. Vaughan, III 
 By my signature below, I hereby acknowledge receipt of this Award on the date shown above, which has been issued to me under the terms and conditions of the Plan. I further acknowledge receipt of the copy of the Plan and agree to conform to
all of the terms and conditions of the Award and the Plan. 
  

							
	 Signature:
	 	  	  	Date:	  	  
		 	Optionee’s Name	  		  	

 Note: If there are any discrepancies in the name or address shown above, please make the appropriate corrections
on this form. 
  

 EXHIBIT A 
 TERMS
AND CONDITIONS 
 STOCK OPTION AGREEMENT 
 1. Exercise of Option. Except as provided in paragraphs 4, 5, 6, 11 and 12 of these Terms and Conditions, this Option shall be exercisable as set forth in the Vesting Schedule for each full year, up to a total of four (4) full
years, that Optionee continues to be employed by the Company after the date of this Agreement. Once this Option has become exercisable with respect to any portion of the total number of shares in accordance with the preceding sentence, it shall
continue to be exercisable with respect to such shares until the termination of Optionee’s rights hereunder pursuant to paragraphs 4, 5 or 6, or until the Expiration Date. A partial exercise of this Option shall not affect Optionee’s right
to exercise subsequently this Option with respect to the remaining shares that are exercisable, subject to the conditions of the Plan and this Agreement. 
 2. Method of Exercising and Payment for Shares. This Option may be exercised only by written notice delivered to the attention of the Company’s Secretary at the Company’s principal office. The written
notice shall specify the number of shares being acquired pursuant to the exercise of the Option when such Option is being exercised in part in accordance with the Vesting Schedule. The exercise date shall be the date such notice is received by the
Company. Such notice shall be accompanied by payment of the Option price in full for each share (a) in cash (United States dollars) or by cash equivalent acceptable to the Company, or (b) by a cashless exercise pursuant to Section IX(2) of
the Plan. 
 3. Nontransferability. This Option is nontransferable except, in the event of the Optionee’s death, by will or by
the laws of descent and distribution subject to the terms hereof. During Optionee’s lifetime, this Option may be exercised only by Optionee. 
 4. Exercise in the Event of Death. This Option shall be exercisable in full in the event that Optionee dies while employed by the Company or an Affiliate and prior to the Expiration Date of this Option. In that event, this Option may
be exercised by Optionee’s estate, or the person or persons to whom his rights under this Option shall pass by will or the laws of descent and distribution. Optionee’s estate or such persons must exercise this Option, if at all, within one
year of the date of Optionee’s death or during the remainder of the period preceding the Expiration Date, whichever is shorter, but in no event may the Option be exercised prior to the expiration of six (6) months from the date of the
grant of the Option. 
 5. Exercise in the Event of Permanent and Total Disability. This Option shall be exercisable in full if
Optionee becomes Disabled while employed by the Company or an Affiliate and prior to the Expiration Date of this Option. In that event, Optionee must exercise this Option, if at all, within one year of the date he becomes Disabled or during the
remainder of the period preceding the Expiration Date, whichever is shorter, but in no event may the Option be exercised prior to the expiration of six (6) months from the date of the grant of the Option. 
 6. Exercise After Termination of Employment. In the event that the Optionee retires from employment with the Company after attaining age 62 and
serving at least 10 consecutive years with the Company or an Affiliate or predecessor thereof, then this Option shall be exercisable in full but must be exercised by the Optionee, if at all, within one year following his retirement date or during
the remainder of the period preceding the Expiration Date, whichever is shorter, but in no event may the Option be exercised prior to the expiration of six (6) months from the date of the grant of the Option. In all events other than those
events addressed in paragraphs 4 or 5 or the foregoing sentence of this paragraph 6, in which Optionee ceases to be employed by the Company: (a) Optionee, subject to the provisions of paragraph 12, may exercise the Option in whole or in part
with respect to that number of shares which are exercisable by him under the Vesting Schedule on the date his employment terminated, and (b) this Option must be exercised by Optionee, if at all, within ninety (90) days following the date
upon which he ceases to be employed by the Company or during the remainder of the period preceding the Expiration Date, whichever is shorter, but in no event may the Option be exercised prior to the expiration of six (6) months from the date of
the grant of the Option. 
 7. Fractional Shares. Fractional shares shall not be issuable hereunder, and when any provision hereof may
entitle Optionee to a fractional share such fraction shall be disregarded. 
 8. No Right to Continued Employment. This Option does
not confer upon Optionee any right with respect to continuance of employment by the Company or an Affiliate, nor shall it interfere in any way with the right of the Company or an Affiliate to terminate his employment at any time. 
 9. Investment Representation. Optionee agrees that, unless such shares previously have been registered under the Securities Act of 1933, as
amended (the “Securities Act”): (i) any shares purchased by him hereunder will be purchased 

 
for investment and not with a view to distribution or resale and (ii) until such registration, certificates representing such shares may bear an
appropriate legend to assure compliance with the Securities Act. This investment representation shall terminate when such shares have been registered under the Securities Act. 
 10. Change in Capital Structure. Subject to any required action by the shareholders of the Company, the number of shares of Common Stock covered
by this Option, and the price per share thereof, shall be proportionately adjusted by the Company for any increase or decrease in the number of issued and outstanding shares of Common Stock of the Company resulting from any stock dividend (but only
on the Common Stock), stock split, combination, reclassification, recapitalization or general issuance to holders of Common Stock of rights to purchase Common Stock at substantially below its then fair market value, or any change in the number of
such shares outstanding effected without receipt of cash or property or labor or services by the Company, or any spin-off or other distribution of assets to shareholders. 
 In the event of a change in the Common Stock of the Company as presently constituted, which is limited to a change of all or a part of its authorized shares without par value into the same number of shares with a par
value, or any subsequent change into the same number of shares with a different par value, the shares resulting from any such change shall be deemed to be the Common Stock within the meaning of the Plan. 
 The grant of this Option pursuant to the Plan shall not affect in any way the right or power of the Company to make adjustments, reclassifications,
reorganizations or changes of its capital or business structure or to merge or to consolidate or to dissolve, liquidate or sell, or transfer all or any part of its business or assets. 
 11. Change of Control. Notwithstanding any other provision of this Agreement to the contrary, in the event of a Change of Control, the provisions
of Section XIII(3) of the Plan shall apply to this Option. 
 12. Forfeiture of Certain Gains. 
 (a) Termination for Cause. If Optionee’s employment is terminated for “Cause” within one year of any exercise of
this Option, in whole or in part, the Optionee shall pay to the Company an amount equal to the gain realized by Optionee from such exercise represented by the excess of the Fair Market Value on the date of exercise over the Option price multiplied
by the number of shares purchased, without regard to any subsequent market price increase or decrease (“Option Gain”). For purposes of this paragraph, “Cause” shall have the meaning ascribed to it in any employment agreement
between the Optionee and the Company that is in effect at the time of termination and, if no such agreement exists, it shall mean: 
 (i) the willful and continued failure of the Optionee to perform substantially the Optionee’s duties with the Company or one of its affiliates (other than any such failure resulting from incapacity due to physical or mental illness),
after a written demand for substantial performance is delivered to the Optionee by the Company which specifically identifies the manner in which the Company believes that the Optionee has not substantially performed the Optionee’s duties, or

 (ii) the willful engaging by the Optionee in illegal conduct or gross misconduct which is materially and demonstrably
injurious to the Company. 
 (b) Forfeiture if Optionee Engages in Certain Activities. If Optionee, between the date
hereof and one year after the date of termination of Optionee’s employment, engages in any activity in competition with any activity of the Company, or inimical, contrary or harmful to the interests of the Company, including but not limited to
(i) accepting employment with or serving as a consultant advisor or in any other capacity to an employer that is in competition with or acting against the interests of the Company, (ii) disclosing or misusing any confidential information
or material concerning the Company or (iii) participating in any hostile takeover attempt, then (1) this Option, including any vested but unexercised shares, shall terminate effective the date on which Optionee enters into such activity,
unless terminated sooner by operation of another term or condition of this Agreement or the Plan, and (2) the Optionee shall pay to the Company an amount equal to the Option Gain realized by Optionee from any exercise of this Option, in whole
or in part, within one year of the date such activity began. 
 (c) Right of Set-off. Optionee hereby consents to a
deduction from any amounts owed by the Company to Optionee from time to time (including amounts owed as wages or other compensation, fringe benefits or vacation pay, to the extent of any amounts Optionee owes the Company under paragraphs 12(a) and
(b). Whether or not the Company elects to make any set-off in whole or in part, if Company does not recover by means of set-off the full amount owed by Optionee under paragraphs 12(a) and (b), Optionee agrees to immediately pay the unpaid balance to
the Company. 
 13. Governing Law. This Agreement shall be governed by and construed and enforced in accordance with the laws of the
Commonwealth of Virginia, except to the extent that federal law shall be deemed to apply. 

 14. Conflicts. In the event of any conflict between the provisions of the Plan as in effect on
the date hereof and the provisions of this Agreement, the provisions of the Plan shall govern. All references herein to the Plan shall mean the Plan as in effect on the date hereof. 
 15. Optionee Bound by Plan. Optionee hereby acknowledges receipt of a copy of the Plan and agrees to be bound by all the terms and provisions
thereof. 
 16. Binding Effect. Subject to the limitations stated above and in the Plan, this Agreement shall be binding upon and
inure to the benefit of the legatees, distributes, and personal representatives of Optionee and the successors of the Company. 
 17.
Gender. All pronouns used herein shall be deemed to refer to either the male or female as appropriate. 
 18. Notice and Consent to
Electronic Delivery. The Company expects to deliver notices and certain documents relating to its employee benefit plans by posting the information on the Company’s web site, intranet or electronic bulletin board or transmitting the
material to employees by e-mail. These documents include employee benefits plans and any amendments thereto, election forms, prospectuses, supplements to prospectuses, annual reports to shareholders, informational brochures and similar
information. The Company will provide you with e-mail notification of the posting of any of the foregoing documents. This method of notification and access to documents relating to employee benefit plans will be in lieu of paper delivery of the
same documents. To satisfy legal requirements, your signature is an affirmative election to accept electronic notification and delivery of these documents in lieu of paper delivery, as well as all other terms of the award. 
 19. Defined Terms. All terms used herein that are defined in the Plan shall have the meanings given to them in the Plan.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00119-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00119-of-00352.parquet"}], [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00119-of-00352.parquet"}]]