Document:

<PAGE>

                                                            HECO Exhibit 10.7(d)
                                                            --------------------

                                                                  EXECUTION COPY

                              GUARANTEE AGREEMENT

                                    between

                               TECO ENERGY, INC.

                                      and

                      HAWAII ELECTRIC LIGHT COMPANY, INC.

     THIS GUARANTEE AGREEMENT ("Guarantee") is made as of this 8/th/ day of
                                                               -----
November, 1999 by and between HAWAII ELECTRIC LIGHT COMPANY, INC. ("HELCO"), a
Hawaii corporation, with principal offices in Hilo, Hawaii, and TECO Energy,
Inc. ("Guarantor"), a Florida corporation, with principal offices in Tampa,
Florida.

                             W I T N E S S E T H:
                             - - - - - - - - - -

     WHEREAS, HELCO is a regulated public utility engaged in the business of
generation, transmission and distribution of electric power to customers on the
island of Hawaii, Hawaii; and

     WHEREAS, Hamakua Energy Partners, L.P., a Hawaii limited partnership, with
principal offices in Charlotte, North Carolina doing business in Hawaii
("SELLER"), is an affiliate of Guarantor; and

     WHEREAS, Encogen Hawaii, L.P., a Delaware limited partnership ("ENCOGEN")
and HELCO entered into a Power Purchase Agreement, dated as of October 22, 1997
(the "Agreement"), whereby ENCOGEN was obligated to construct, operate and
maintain a 60 MW (net) cogeneration facility (the "Facility") at Haina, Hawaii
and HELCO was obligated to purchase the electric output from the Facility over a
period of thirty (30) years; and

     WHEREAS, HELCO was willing to enter into the assignment of the Agreement
only if the Guarantor enters into this Guarantee with HELCO; and

     WHEREAS, to induce HELCO to enter into the assignment of the Agreement,
Guarantor is willing to enter in this Guarantee with HELCO.

     NOW, THEREFORE, in consideration of these premises and other good and
valuable consideration, the receipt and sufficiency of which are hereby
acknowledged, Guarantor hereby represents, warrants, covenants and agrees with
HELCO as follows:
<PAGE>

          1.   Definitions. All capitalized terms used herein and not defined
               -----------
herein, and which are defined in, or by reference in, the Agreement, as the
Agreement may be amended from time to time in accordance with its terms, shall
have the meanings specified in the Agreement.

          2.   Guarantee.
               ---------

               a.   Subject to the limitations contained in Section 3, Guarantor
hereby guarantees to HELCO the due and punctual payment, as and when due, of
fifty percent (50%) (the "Proportionate Share") of all sums payable by SELLER to
HELCO as the result of the nonperformance of obligations under the Agreement or
other events or circumstances during the term of the Agreement. This Guarantee
is one of two identical Guarantees being provided by Guarantor and J.A. Jones,
Inc. in accordance with Section 21.1 of the Agreement, each of which constitutes
a several, not joint, obligation of Guarantor and J.A. Jones, Inc.,
respectively, with respect to any sums payable by SELLER to HELCO under the
Agreement. In no event shall HELCO have recourse against Guarantor in excess of
the lesser of its Proportionate Share of SELLER's payment obligations or the
limits set forth in Section 3 below.

               b.   The Guarantee is a primary and original obligation of
Guarantor and is an absolute, unconditional, continuing and irrevocable
guarantee and is in no way conditioned or contingent upon any attempt to collect
payment from or proceed against SELLER except as stated otherwise herein. This
Guarantee shall remain in full force and effect until the earlier to occur of
the following events: (i) all of SELLER's obligations under the Agreement
including, without limitation, any obligations for breach thereof, have been
fulfilled; (ii) this Guarantee has been substituted for in accordance with
Section 21.1 of the Agreement, or (iii) the termination of the Agreement;
provided, that obligations arising prior to such termination date shall survive
--------
such termination. Any notice required to be given by HELCO to SELLER under the
Agreement shall also be given by HELCO to Guarantor at:

                          TECO Energy, Inc.
                          702 N. Franklin Street
                          Tampa, Florida 33602
                          (813) 228-1804 (telephone)
                          (813) 228-1328 (facsimile)

(or such other address as Guarantor may designate in writing to HELCO).
Guarantor shall have the same opportunity to cure defaults by SELLER under the
Agreement as SELLER shall have; provided, however, that no time period provided
in the Agreement for cure shall be extended or start anew by virtue of this
sentence.

          In the event that the Agreement shall be terminated as a result of the
rejection or disaffirmance thereof by any trustee, receiver or liquidating
agency of SELLER or any of its properties, in any assignment for the benefit of
creditors or any bankruptcy, insolvency, reorganization, arrangement,
composition, readjustment, liquidation, dissolution or similar proceeding.
Guarantor's obligations hereunder shall continue to the same extent as if such
Agreement had not been so rejected or disaffirmed. Guarantor shall, and does
hereby waive all rights and benefits which might relieve, in whole or in part,
Guarantor from the performance of

                                       2
<PAGE>

its duties and obligations hereunder by reason of any such proceeding, and
Guarantor agrees that it shall be liable for all sums and obligations guaranteed
by this Guarantee without regard to any modification, limitation or discharge of
the liability of SELLER that may result from any such proceeding.

          3.   Guarantee Limits. Guarantor's obligations under Section 2(a)
               ----------------
hereof in the aggregate shall be limited to the amounts shown below with respect
to sums as payable by SELLER to HELCO pursuant to the Agreement as the result of
events or circumstances during the period shown opposite such amounts:

               Period                                  Amount*
               ------                                  ------

Until PUC Approval                                   $      -0-
From PUC Approval through Closing Date               $  100,000
From the Closing Date through the Phase 2            $  500,000
In-Service Date
From Phase 2 In-Service Date to end of Term          $1,500,000

*Guarantor's obligations in any given period shall be reduced by any amounts
paid by Guarantor with respect to such obligations in all preceding periods.

As used above, "PUC Approval" shall mean the date that the PUC order referred to
in Section 23.14 of the Agreement becomes final and non-applicable.

          4.   Generally. Guarantor shall not be liable under Section 2 of this
               ---------
Guarantee to any extent greater than if it had been the contracting party (in
place of SELLER) under the Agreement, and all the representations and warranties
made by Guarantor in Section 5 hereof in respect of this Guarantee were true in
respect of the Agreement as well as the Guarantee and notwithstanding any
bankruptcy or insolvency of SELLER. In addition, Guarantor shall have no
obligation under Section 2(a) of this Guarantee for any claim for payment,
performance or otherwise attributable to events or circumstances during the
period prior to the Phase 2 In-Service Date, not asserted by HELCO in writing
within one hundred eighty (180) days after the Phase 2 In-Service Date.

          5.   Representations and Warranties. Guarantor represents and warrants
               ------------------------------
as follows:

               a.   Guarantor has full power, authority and legal right to
execute and deliver and perform its obligations under this Guarantee. This
Guarantee has been duly executed and delivered by Guarantor and constitutes a
legal, valid and binding obligation of Guarantor, enforceable in accordance with
its terms, except to the extent that such enforcement may be limited by any
bankruptcy, reorganization, insolvency, moratorium or similar laws affecting
generally the enforcement of creditors" rights from time to time in effect and
general principles of equity.

                                       3
<PAGE>

          b.   No consent, authorization or approval of, or filing with, any
federal, state, municipal or other governmental department, commission, board,
bureau, agency or instrumentality, domestic or foreign, is or has been required
in respect of Guarantor in connection with the execution, delivery or
performance by Guarantor of this Guarantee, or the compliance by Guarantor with
any of the terms and provisions hereof.

          c.   The execution and delivery of, and performance by Guarantor of
its obligations under this Guarantee will not result in a violation of, or be in
conflict with, any provision of the articles of incorporation or bylaws of
Guarantor, or result in a violation of, or be in conflict with, or constitute a
default or an event which would, with notice or lapse of time, or both, become a
default under, any mortgage, indenture, contract, agreement or other instrument
to which Guarantor is a party or by which it or its property is bound, or result
in a violation of, or be in conflict with, or result in a breach of, any term or
provision of any judgment, order, decree or aware of any court, arbitration or
governmental or public instrumentality binding upon Guarantor or its property,
which individually or in the aggregate would materially adversely affect
Guarantor's ability to perform its obligations under this Guarantee.

          d.   Guarantor is not in default, and no condition exists which, with
notice of lapse of time, or both, would constitute a default by Guarantor under
any mortgage, loan agreement, deed or trust, indenture or other agreement with
respect thereto, evidence of indebtedness or other instrument of a material
nature, to which it is party or by which it is bound, or in violation of, or in
default under, any rule, regulation, order, writ, judgment, injunction or decree
of any court, arbitration or federal, state, municipal or other governmental
authority, commission, board, bureau, agency, or instrumentality, domestic or
foreign, which individually or in the aggregate would materially adversely
affect Guarantor's ability to perform its obligations under this Guarantee.

          e.   There is no action, suit, proceeding, inquiry or investigation,
at law or in equity, or before or by any court, public board or body, pending
against Guarantor, or of which Guarantor has otherwise received official notice,
or which to the knowledge of Guarantor is threatened against Guarantor, wherein
an adverse decision, ruling or finding would have a material adverse effect on
the Guarantor's financial position or its ability to perform its obligations
under this Guarantee.

          f.   All agreements, representations and warranties contained herein
or made in writing by or on behalf of Guarantor in connection with the
transaction contemplated hereby shall survive the execution and delivery of this
Guarantee.

     6.   Notice. Guarantor shall give written notice to HELCO and SELLER within
          ------
ten (10) days after (i) the occurrence of any event or circumstance that results
in any of the representations and warranties made by Guarantor in Section 5
ceasing to be accurate, or (ii) the occurrence, with respect to Guarantor, of
any of the events specified in paragraphs (10) or (11) of Section 7.1A of the
Agreement as constituting an Event of Default upon the occurrence thereof with
respect to SELLER. Such notice shall describe, with reasonable particularity,
the event or circumstance that has caused such result and shall specify the
effect thereof on all representations and warranties of Guarantor that are
affected thereby.

                                       4
<PAGE>

     7.   Miscellaneous.
          -------------

          a.   Severability. If any term or provision of this Guarantee or the
               ------------
application thereof to any person, entity or circumstance shall to any extent be
invalid or unenforceable, the remainder of this Guarantee, or the application of
such term or provision to persons, entities or circumstances other than those as
to which it is invalid or unenforceable, shall not be affected thereby, and each
term and provision of this Guarantee shall be valid and enforceable to the
fullest extent permitted by law.

          b.   No Waiver. Except as specifically provided otherwise herein, the
               ---------
failure of either parry to enforce at any time any of the provisions of this
Guarantee, or to require at any time performance by the other party of any of
the provisions thereof, shall in no way be construed to be a waiver of such
provisions, nor in any way to affect the validity of this Guarantee or any part
hereof, or the right of such party thereafter to enforce every such provision.

          c.   Modification. No modification or waiver of all or any part of
               ------------
this Guarantee shall be valid unless it is reduced to writing and signed by both
parties.

          d.   Governing Law and Interpretation. Interpretation and performance
               --------------------------------
of this Guarantee shall be in accordance with, and shall be controlled by, the
laws of the State of Hawaii, other than the laws thereof that would require
reference to the laws of any other jurisdiction.

          e.   Counterparts. this Guarantee may be executed in several
               ------------
counterparts and all such executed counterparts shall constitute one agreement,
binding on both parties thereto, notwithstanding that both parties may not be
signatories to the original or the same counterpart.

          f.   Successors and Assigns. This Guarantee shall be binding upon
               ----------------------
Guarantor and its successors and assigns and all persons claiming under or
though Guarantor or any such successor or assign, and shall inure to the benefit
of, and be enforceable by, HELCO.

          g.   Consolidation. In the event that HELCO brings an action to
               -------------
enforce this Guarantee during the pendency of any proceeding (arbitration or
otherwise) between HELCO and SELLER, Guarantor shall have the option to join
such enforcement action with any such pending proceeding. Moreover, Guarantor
shall have the option to join any such proceeding first brought against
Guarantor with any subsequent proceeding brought against SELLER. In each of the
cases described above, such joinder option shall extend until such time as a
final judgment is rendered in the relevant proceeding.

                                       5
<PAGE>

     IN WITNESS WHEREOF, HELCO and Guarantor have caused this Guarantee to be
executed by their respective duly authorized officers as of the date first above
written.

               HELCO          HAWAII ELECTRIC LIGHT COMPANY, INC.

                              By /s/ Warren H. W. Lee
                                 --------------------------------------
                                 Its President
                                 --------------------------------------

                              By /s/ Edward Y. Hirata
                                 --------------------------------------
                                 Its Vice President
                                 --------------------------------------

               Guarantor      TECO ENERGY, INC.

                              By /s/ Gordon L. Gillette
                                 --------------------------------------
                                 Gordon L. Gillette
                                 Vice President-Finance and
                                    Chief Financial Officer

                                       6<PAGE>

                                                                   Exhibit 10.22

STATE OF NORTH CAROLINA

COUNTY OF DURHAM

                   LEASE ASSIGNMENT AND MODIFICATION AGREEMENT

         THIS LEASE ASSIGNMENT AND MODIFICATION AGREEMENT (the "Agreement") is
made and entered into as of July ____, 2001 by and among BLUE CROSS AND BLUE
SHIELD of NORTH CAROLINA, a North Carolina corporation and a licensee of the
Blue Cross and Blue Shield Association ("Assignor"), TRIMERIS, INC., a Delaware
corporation ("Assignee"), and HAMAD JASSIM ALTHANI ("Landlord").

                              STATEMENT OF PURPOSE
                              --------------------

         Assignor is the current tenant under that certain Lease Agreement with
Landlord dated as of November 8, 1994 as amended by First Amendment to Lease
dated December 15, 1995 and by Second Amendment to Lease dated February 1, 1999
(the Lease Agreement as amended being hereinafter referred to as the "Existing
Lease") demising approximately 15,658 rentable square feet on the third floor of
the South Park Office Center located at 3518 Westgate Drive, Durham, North
Carolina and more particularly described in the Lease (the "Premises");

         Assignee currently occupies the Premises pursuant to a Sublease
Agreement dated May 12, 1999 (the "Sublease") by and between Assignor as
"Sublandlord" and Assignee as "Subtenant";

         Assignor desires to terminate the Sublease and assign to Assignee all
of its right, title and interest in and to the Existing Lease, and Assignee
desires to assume the Assumed Obligations (as hereinafter defined);

         Assignor has requested that Landlord consent to the assignment of the
Existing Lease to Assignee and Landlord is willing to consent to same on the
following terms and conditions; and

         Landlord, Assignor and Assignee desire to modify certain terms and
conditions of the Existing Lease including, but not limited to, the base rent
payable by Assignee for the remainder of the Lease Term. For purposes hereof,
the Existing Lease as modified by this Agreement is referred to as the "Lease."
All capitalized terms not otherwise defined herein shall have the meanings set
forth in the Existing Lease.

         NOW, THEREFORE, in consideration of the agreements contained herein and
other good and valuable consideration, the receipt and adequacy of which are
hereby acknowledged, the parties hereto agree as follows:

                                       1

<PAGE>

                                    AGREEMENT
                                    ---------

     1.    Assignment of Lease.  Effective as of December 31, 2001 (the
           -------------------
"Assignment Commencement Date"), Assignor does hereby assign, transfer, and set
over unto Assignee all of the right, title and interest of Assignor in, to and
under the Lease, as herein amended. Assignor, simultaneously herewith, assigns
to Assignee, all of Assignor's right, title, and interest in and to the
leasehold improvements and all remaining tangible personal property (if any)
located in the Premises including, without limitation, equipment, office
supplies, furniture and fixtures (collectively, the "Assigned Property").

     Assignee hereby assumes and accepts the foregoing assignment on the terms
and conditions set forth herein and effective upon the Assignment Commencement
Date, assumes and agrees to keep, observe and perform all of the terms,
covenants, agreements, conditions and obligations of the Lease on the part of
the Assignor to be kept, observed and performed which accrue on or after the
Assignment Commencement Date, including, without limitation, the payment of all
rent (as modified by Section 5 below), additional costs, payments and charges
which accrue after the Assignment Commencement Date (collectively, the "Assumed
Obligations"), with the same force and effect as if the Assignee instead of
Assignor had originally signed the Lease, and agrees that it shall, from and
after the Assignment Commencement Date, be liable to Landlord and its respective
successors and assigns, for any failure to keep, observe or perform the same.
Assignee shall not be liable to Landlord for any matters accruing under the
Lease prior to the Assignment Commencement Date. Assignor shall not be liable to
Landlord for any matters accruing under the Lease after the Assignment
Commencement Date.

     Assignee acknowledges that it currently occupies the Premises under the
Sublease and accepts same in its "as-is, where-is" condition with no obligation
on the part of Assignor or Landlord to make any improvements to the same.

     2.    Indemnity. Assignee agrees to indemnify, defend and hold harmless
           ---------
Assignor and all its affiliates, subsidiaries, related corporations, related
partnerships, officers, directors, employees and agents from and against any and
all liabilities, claims, suits, actions, losses, damages, penalties, costs and
expenses (including, without limitation, attorneys' fees and disbursements) due
to or arising out of or related to Assignee's use, possession or occupancy of
the Premises and/or the Assigned Property, the exercise of any rights with
respect to the Lease, the Premises and/or the Assigned Property and/or any
failure to keep, observe and perform the Assumed Obligations with respect to any
period from and after the Assignment Commencement Date.

     Assignor agrees to indemnify, defend and hold harmless Assignee and all its
affiliates, subsidiaries, related corporations, related partnerships, officers,
directors, employees and agents from and against any and all liabilities,
claims, suits, actions, losses, damages, penalties, costs and expenses
(including, without limitation, attorneys' fees and disbursements) due to or
arising out of or related to Assignor's use, possession or occupancy of the
Premises and/or the Assigned Property, the exercise of any rights with respect
to the Lease, the Premises and/or the Assigned

                                       2

<PAGE>

Property and/or any failure to keep, observe and perform the terms, covenants,
agreements, conditions and obligations of the Lease on the part of the Assignor
to be kept, observed and performed with respect to any period prior to and
including the Assignment Commencement Date.

     3.    Consent to Assignment. Notwithstanding the provisions of Section 21
           ---------------------
of the Existing Lease, Landlord does hereby consent to Assignor's assignment of
the Lease to Assignee. Landlord's consent to this assignment does not constitute
a waiver of its right to consent to any subsequent assignment of the Lease.
Assignor, by its execution below, hereby acknowledges its continuing liability
to Landlord under the Lease with respect to all matters accruing prior to the
Assignment Commencement Date and agrees and acknowledges that its liability to
Landlord thereunder is not waived, discharged, modified, released, amended, or
otherwise altered by the assignment described herein. Assignee, by its execution
below, hereby acknowledges its liability to Landlord under the Lease (as herein
modified) with respect to all matters accruing as of and after the Assignment
Commencement Date. Landlord acknowledges that Assignor shall have no liability
with respect to any obligations accruing under the Lease after the Assignment
Commencement Date.

     4.    Term; Expiration Date: The "Term" of this Lease shall be one (1) year
           ---------------------
commencing as of the Assignment Commencement Date and expiring on the first
(1st) anniversary of the Assignment Commencement Date. The Renewal Options set
forth in Exhibit E of the Lease and in Section 5 of the First Amendment to Lease
are hereby deleted and shall be of no further force and effect, and Assignee
shall have no rights to renew the Term of this Lease.

     5.    Modification of Rent. Beginning on the Assignment Commencement Date,
           --------------------
Assignee agrees to pay to Landlord, at the address set forth in Section 9
hereinbelow, Annual Rent in the amount of Three Hundred Eighty Three Thousand
Six Hundred Twenty-One and 04/100 Dollars ($383,621.04) for the Lease Term,
payable in monthly installments of Thirty One Thousand Nine Hundred Sixty-Eight
and 42/100 Dollars ($31,968.42) in accordance with the terms and conditions of
the Lease. Assignee shall continue to pay all additional rent and other sums
payable under the Lease accruing from and after the Assignment Commencement Date
pursuant to the terms and conditions of the Lease.

     6.    Security Deposit: Notwithstanding the provisions of Section 21 of the
           ----------------
Sublease, the $23,656.53 deposit which Assignor (as Sublandlord) holds will be
transferred to Landlord on the Assignment Commencement Date.

     7.    Operating Expenses: In addition to the Annual Rent set forth in
           ------------------
Section 5 of this Agreement, Assignee agrees to pay Landlord its pro-rata share
of the operating expenses (as defined in the Lease) of Landlord for the building
and/or the project of which the Premises is a part, in excess of the sum of Five
and 35/100 Dollars ($5.35) per rentable square foot pursuant to the terms and
conditions of the Lease.

     8.    Termination of Sublease. Assignor and Assignee agree that effective
           -----------------------
as of the Assignment Commencement Date, the Sublease shall be deemed terminated
and of no further force and effect.

                                       3

<PAGE>

     9.    Notice. Any notice required to be given by any party to another shall
           ------
be in writing and shall be (a) delivered personally, and the giving of such
notice shall be complete on the date of deliver; (b) sent by reputable overnight
delivery service, and the giving of such notice shall be complete on the
immediately succeeding business day after such notice is deposited with such
delivery service, or (c) sent by United States registered or certified mail,
postage prepaid, return receipt requested, and the giving of such notice shall
be complete on the immediately succeeding second business day after such notice
is deposited into the U.S. mail; at the following addresses:

     Assignor:
     --------

     If by Regular Mail:

     Blue Cross and Blue Shield of North Carolina
     Post Office Box 2291
     Durham, North Carolina 27702-2291
     Attention: Director of Corporate Services, Michael Patrick

     If by Overnight Mail:

     Blue Cross and Blue Shield of North Carolina
     5901 Chapel Hill Road
     Durham, North Carolina 27707-0718
     Attention: Director of Corporate Services, Michael Patrick

     Assignee:
     --------
     Trimeris, Inc.
     Two University Place, Suite 100
     4727 University Drive
     Durham, North Carolina 27707
     Attention: Chief Financial Officer

     Landlord:
     --------
     Hamad Jassim Althani
     c/o  Tri Properties, Inc.
     4309 Emperor Blvd., Suite 110
     Durham, North Carolina  27703

     10.   Miscellaneous.
           -------------

     a.  This Agreement shall bind and inure to the benefit of Landlord,
Assignor, Assignee, and their respective successors and assigns.

     b.  Landlord and Assignor represent and warrant that the Lease is currently
in full force and effect and constitutes the entire agreement between Landlord
and Assignor. The copy of the

                                       4

<PAGE>

Lease attached hereto as Exhibit A is a true and correct copy of the Lease and
                         ---------
all amendments, supplements and modifications thereof. Landlord acknowledges and
agrees that there exists no Event of Default under the Lease or any event which,
with the passage of any applicable notice and/or grace period without remedy,
would constitute an Event of Default.

     c. This Agreement may be executed in one or more counterparts, each of
which shall be deemed an original hereof and all of which shall be considered
one and the same instrument.

     d. Each of Landlord, Assignor and Assignee certifies and represents (each
with respect to itself) that it has the power and authority to enter into this
Agreement and that this Agreement has been duly authorized by all necessary
action of each of them.

     e. The parties hereto acknowledge and agree that all terms of the Existing
Lease shall remain in full force and effect without modification except as set
forth herein.

     f. This Agreement shall be construed and governed by the laws of the State
of North Carolina.

     IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of
the date first written above.

                                 ASSIGNOR:

                                 BLUE CROSS AND BLUE SHIELD
                                 of NORTH CAROLINA,
                                 a North Carolina corporation and a licensee
                                 of the Blue Cross and Blue Shield Association

                                 By:  /s/ DANIEL E. GLASER
                                 Name: Daniel E. Glaser
                                 Title: Senior Vice President

                                 Date:  9/23/01

                                 ASSIGNEE:

                                 TRIMERIS, INC.,
                                 a Delaware corporation

                                 By:  /s/ DANI BOLOGNESI
                                 Name: Dani Bolognesi
                                 Title:  CEO

                                 Date: 9/18/01

                                       5

<PAGE>

                                    LANDLORD:

                                    HAMAD JASSIM ALTHANI by RAJAI ZUMOT

                                    By:  /s/ RAJAI ZUMONT
                                         ----------------
                                    Name:    Rajai Zumot
                                    Title:   Agent

                                    Date: Sept. 27, 2001

                                       6

<PAGE>

                                    EXHIBIT A
                                    ---------

                                   THE LEASE*

* Previously filed with the Commission and incorporated by reference to
Trimeris' Quarterly Report on Form 10-Q for the quarter ended June 30, 1999.

                                       7

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