Document:

Exclusive License Agreement

 Exhibit 10.2 
 Confidential Treatment has been requested for portions of this exhibit. The copy filed herewith omits the information subject to the confidentiality request. Omissions are designated “***”. A
complete version of this exhibit has been filed separately with the Securities and Exchange Commission. 
 EXCLUSIVE LICENSE
AGREEMENT 
 This Exclusive License Agreement (this “Agreement”) is made and entered into effective
as of September 29, 2011 (the “Effective Date”) between, on the one hand, Intellect Neurosciences, Inc., a corporation organized under the laws of Delaware (“Intellect Neurosciences”) and
Intellect USA, Inc., a corporation organized under the laws of Delaware (“Intellect USA” and, collectively with Intellect Neurosciences, “INS”), and, on the other hand, ViroPharma Incorporated, a
corporation organized under the laws of Delaware (“ViroPharma”). INS and ViroPharma are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

 RECITALS 
 WHEREAS, INS owns or controls certain information, data and intellectual property relating to a chemical compound known as OX1; 

WHEREAS, ViroPharma desires to develop and commercialize one or more products relating to such data and intellectual property;

 WHEREAS, INS desires to grant certain licenses to ViroPharma, and ViroPharma desires to obtain certain licenses from
INS, to develop and commercialize one or more such products in accordance with the terms and conditions of this Agreement; and 

WHEREAS, the Parties acknowledge and agree that INS currently has and will have development and commercialization programs,
including, but not limited to, with respect to Alzheimer’s Disease, that are unrelated to this Agreement. 
 NOW,
THEREFORE, in consideration of the foregoing premises and the mutual promises and covenants of the Parties contained herein, the Parties, intending to be legally bound, do hereby agree as follows: 

ARTICLE 1 

DEFINITIONS 
 Unless otherwise specifically provided herein, the following terms shall have the following meanings: 
 1.1 “Academic Indemnitees” has the meaning set forth in Section 11.1.2. 
 1.2 “Academic License” means the Amended and Restated License Agreement, effective as of September 29, 2011, by and among NYU, SAMSF and Intellect USA, Inc. 

 1.3 “Academic Losses” has the meaning set forth in
Section 11.1.2. 
 1.4 “Acceptance” means, with respect to an NDA, the occurrence of the earlier
of: (a) the expiration of the period specified in applicable regulations for any notice by the FDA that such NDA will not be accepted for review, without ViroPharma or one of its Affiliates having received such notice from the applicable
Regulatory Authority; or (b) the receipt by ViroPharma or one of its Affiliates from the applicable Regulatory Authority that the NDA will be accepted for review, provided that in any case, if no such period for acceptance is provided
for in the applicable regulations, then the NDA shall be deemed “accepted” on the date such NDA was submitted. 
 1.5
“Acquisition” with respect to a Party, means a merger, acquisition (whether of all of the stock or all or substantially all of the assets of a Person or any operating or business division of a Person) or similar transaction
by or with the Party, other than a Change in Control of the Party. 
 1.6 “Affiliate” means, with
respect to a Party, licensee or sublicensee, any Person that, directly or indirectly, through one or more intermediaries, controls, is controlled by or is under common control with such Party, licensee or sublicensee, as the case may be. For
purposes of this definition, “control” and, with correlative meanings, the terms “controlled by” and “under common control with” as used with respect to a Person (including a
Party, licensee or sublicensee) means (a) the possession, directly or indirectly, of the power to direct, or cause the direction of, the management or policies of such Person (including a Party, licensee or sublicensee), whether through the
ownership of voting securities, by contract relating to voting rights or corporate governance, or otherwise, or (b) the ownership, directly or indirectly, of more than fifty percent (50%) of the voting securities or other ownership
interest of a Person (including a Party, licensee or sublicensee). 
 1.7 “Agreement” has the meaning
set forth in the Preamble. 
 1.8 “***” means (a) the ***, other than *** and ***, and also (b) the *** in
***, and includes the ***. 
 1.9 “Applicable Law” means applicable laws, rules and regulations,
including but not limited to any rules, regulations, guidelines or other requirements of any Regulatory Authority, that may be in effect from time to time. 
 1.10 “Asset Transfer Agreement” has the meaning set forth in Section 10.3.6. 
 1.11 “Board of Directors” has the meaning set forth in Section 1.18.1. 
 1.12 “Breaching Party” has the meaning set forth in Section 12.2. 
 1.13 “Business Day” means a day other than a Saturday, Sunday or a day on which banking institutions in New York, New York are required or permitted by law to remain closed.

  
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 1.14 “Calendar Quarter” means each successive period of three
(3) calendar months commencing on January 1, April 1, July 1 and October 1. 
 1.15
“Calendar Year” means each successive period of twelve (12) calendar months commencing on January 1 and ending on December 31. 
 1.16 “***” has the meaning set forth in Section 10.3.12. 
 1.17
“***” has the meaning set forth in Section 10.3.12. 
 1.18 “Change in Control,” with
respect to a Party, shall be deemed to have occurred if any of the following occurs after the Effective Date: 
 1.18.1. any
“person” or “group” (as such terms are defined below) (a) is or becomes the “beneficial owner” (as defined below), directly or indirectly, of shares of capital stock or other interests (including partnership
interests) of such Party then outstanding and normally entitled (without regard to the occurrence of any contingency) to vote in the election of the directors, managers or similar supervisory positions (“Voting Stock”) of
such Party representing fifty percent (50%) or more of the total voting power of all outstanding classes of Voting Stock of such Party or (b) has the power, directly or indirectly, to elect a majority of the members of the Party’s
board of directors or similar governing body (“Board of Directors”); or 
 1.18.2. such Party enters
into a merger, consolidation or similar transaction with another Person (whether or not such Party is the surviving entity) and as a result of such merger, consolidation or similar transaction (a) the members of the Board of Directors of such
Party immediately prior to such transaction constitute less than a majority of the members of the Board of Directors of such Party or such surviving Person immediately following such transaction or (b) the Persons that beneficially owned,
directly or indirectly, the shares of Voting Stock of such Party immediately prior to such transaction cease to beneficially own, directly or indirectly, shares of Voting Stock of such Party representing at least a majority of the total voting power
of all outstanding classes of Voting Stock of the surviving Person in substantially the same proportions as their ownership of Voting Stock of such Party immediately prior to such transaction; or 

1.18.3. such Party sells or transfers to any Third Party, in one or more related transactions, properties or assets representing all or
substantially all of such Party’s consolidated total assets; or 
 1.18.4. the holders of capital stock of such Party
approve a plan or proposal for the liquidation or dissolution of such Party. 
 For the purpose of this definition of Change in
Control, (a) “person” and “group” have the meanings given such terms under Section 13(d) and 14(d) of the United States Securities Exchange Act of 1934 and the term “group” includes any group acting for the
purpose of acquiring, holding or disposing of securities within the meaning of Rule 13d-5(b)(1) under the said Act, (b) a “beneficial owner” shall be determined in accordance with Rule 13d-3 under the aforesaid Act, and (c) the
terms “beneficially owned” and “beneficially own” shall have meanings correlative to that of “beneficial owner.” 

  
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 1.19 “Clinical Data” means all Information with respect to the
Licensed Products made, collected or otherwise generated under or in connection with the Clinical Trials for the Licensed Products, including any data, reports and results with respect thereto. 

1.20 “Clinical Trial” means a Phase I Clinical Trial, Phase II Clinical Trial, Phase III Clinical Trial, Phase IV
Clinical Trial or Phase V Clinical Trial and such other tests and studies in humans that are required by Applicable Law to obtain or maintain Regulatory Authorization of a Licensed Product, and “Clinical Trials” means all of
the foregoing clinical trials. 
 1.21 “Commercialization” means any and all activities (whether before
or after Regulatory Authorization) directed to the marketing, detailing and promotion of the Licensed Products after Regulatory Authorization for commercial sale has been obtained, and shall include marketing, promoting, detailing, marketing
research, Manufacturing, distributing, offering to commercially sell and commercially selling the Licensed Products, importing, exporting or transporting the Licensed Products for commercial sale and regulatory affairs with respect to the foregoing.
When used as a verb, “Commercializing” means engaging in Commercialization and “Commercialize” and “Commercialized” shall have corresponding meanings. 

1.22 “Commercially Reasonable Efforts” means, with respect to the research, Development, Commercialization or
other Exploitation of a particular Licensed Product, the efforts and resources commonly used in the research-based pharmaceutical industry for products with similar commercial and scientific potential, taking into account all relevant factors
including, as applicable and without limitation, stage of development, mechanism of action, efficacy and safety relative to competitive products in the marketplace, actual or anticipated Regulatory Authority approved labeling, the nature and extent
of market exclusivity (including patent coverage and regulatory exclusivity), cost and likelihood of obtaining Commercialization Regulatory Approval, and actual or projected profitability, in all cases, as applicable, on a market-by-market and
indication-by-indication basis for a particular Licensed Product. 
 1.23 “Competitor” means any Person
that derives a material portion of its revenues from *** or *** intended for ***, which ***, in the case of *** or ***, are the subject of *** for *** and, in the case of *** or *** and *** which are directly competitive in *** or *** with *** or
*** or *** from which ***, and, in the *** or ***, for which *** has *** or *** in the ***. 
 1.24 “Confidential
Information” has the meaning set forth in Section 9.1. 
 1.25 “Control” means, with
respect to any item of Information, Regulatory Documentation, Patent, Trademark or other intellectual property right, possession of the right, whether directly or indirectly, and whether by ownership, license or otherwise (other than by operation of
any license and other grants hereunder), to assign or grant a license, sublicense or other right to or under such Information, Regulatory Documentation, Patent, Trademark or other intellectual property right as provided for herein without violating
the terms of any agreement or other arrangement with any Third Party, including the Academic License. With respect to any intellectual property rights owned by a Third Party and Controlled under the terms of a license or other agreement, a Party
will be deemed to Control such intellectual property rights solely to the 

  
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extent that the applicable agreement remains in effect and permits such Control, and the grant of rights in such intellectual property is conditioned on the acceptance by the Party granted such
rights of any undertaking or obligations established by the applicable license or other agreement. 
 1.26 “Data
Exclusivity” means a marketing or data exclusivity right conferred as a result of (a) designation as a drug for rare diseases or conditions under Sections 525 et seq. of the FDC Act, (b) an exclusive right to sell under
an NDA pursuant to Section 505(j)(5)(F)(ii), (iii) and (iv) or 505(c)(3)(E)(ii), (iii) and (iv) of the FDC Act or any relevant subsequent legislation, rules or regulations, (c) the exclusive right granted by the FDA
upon completion of pediatric studies requested by the FDA under Section 505A of the FDC Act, (d) Article 10 of EU Directive 2001/83/EC and/or Article 3(3) of EU Regulation 726/2004/EC or (e) EU Regulations 141/2000/EC and/or
847/2000/EC, as applicable, or any equivalent or similar rights in the Territory, successor legislations of any of the foregoing or subsequent legislation that has the effect of extending marketing or data exclusivity right to a pharmaceutical
product. 
 1.27 “Development” means all activities related to pre-clinical and clinical testing, test
method development and stability testing, toxicology, formulation, process development, manufacturing scale-up, qualification and validation, quality assurance/quality control, Clinical Trials, including Manufacturing in support thereof, statistical
analysis and report writing, the preparation and submission of Regulatory Documentation, regulatory affairs with respect to the foregoing and all other activities necessary or reasonably useful or otherwise requested or required by a Regulatory
Authority as a condition or in support of obtaining, maintaining or modifying a Regulatory Authorization. When used as a verb, “Develop” means to engage in Development. 

1.28 “Dispute” has the meaning set forth in Section 13.7.1. 

1.29 “EU” means the European Union, as its membership may be altered from time to time, and any successor
thereto. As of the Effective Date, the member countries of the EU are Austria, Belgium, Bulgaria, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, The
Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden and the United Kingdom. 
 1.30
“Exploit” means to make, have made, import, use, sell or offer for sale, including to research, Develop, Commercialize, register, Manufacture, have Manufactured, hold or keep (whether for disposal or otherwise), have used,
export, transport, distribute, promote, market or have sold or otherwise dispose of, and “Exploitation” means the act of Exploiting a product or process. 

1.31 “FDA” means the United States Food and Drug Administration, and any successor agency thereto. 

1.32 “FDC Act” means the Federal Food, Drug, and Cosmetic Act, as amended. 

1.33 “Field” means all use of Licensed Products in humans and animals, including (a) all indications of
Licensed Products for the diagnosis, treatment, management or prevention of any disease or condition in humans or animals and (b) all consumption of Licensed Products by humans or animals (including by way of *** or ***). 

  
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 1.34 “First Commercial Sale” means, with respect to a Licensed
Product and country, the first sale for use of such Licensed Product in such country after any and all Regulatory Authorizations necessary for commercial sale of such Licensed Product in such country have been obtained. 

1.35 “GAAP” means United States generally accepted accounting principles consistently applied. 

1.36 “Good Manufacturing Practice” or “GMP” means the current good manufacturing
practices applicable from time to time to the manufacturing of a Licensed Product or any intermediate thereof pursuant to Applicable Law. 
 1.37 “Hatch-Waxman Act” means the Drug Price Competition and Patent Term Restoration Act of 1984, as amended. 

1.38 “Improvements” means any and all Information and inventions that are conceived, discovered, developed or
otherwise made by or on behalf of a Party or the Parties in connection with the work conducted under or in connection with this Agreement, whether patentable or not. 
 1.39 “IND” means an investigational new drug application as defined in the FDC Act, and the regulations promulgated thereunder, submitted to the FDA for authorization to commence
Clinical Trials or its equivalent in other countries or regulatory jurisdictions. 
 1.40 “Indemnification Claim
Notice” has the meaning set forth in Section 11.3. 
 1.41 “Indemnified Party” has the
meaning set forth in Section 11.3. 
 1.42 “Information” means all technical, scientific and other
know-how and information, trade secrets, knowledge, technology, means, methods, processes, practices, formulae, instructions, skills, techniques, procedures, experiences, expressed ideas, technical assistance, designs, drawings, assembly procedures,
computer programs, apparatuses, specifications, data, results and other material, including: biological, chemical, pharmacological, toxicological, pharmaceutical, physical and analytical, pre-clinical, clinical, safety, manufacturing and quality
control data and information, including study designs and protocols; assays and biological methodology (whether or not confidential, proprietary, patented or patentable) in written, electronic or any other form known as of the Effective Date or
hereafter developed. 
 1.43 “Initial Regulatory Authorization” of a Licensed Product for an indication
means (a) with respect to the United States, the approval by the FDA and, (b) with respect to a country or jurisdiction other than the United States, the approval by the applicable Regulatory Authorities of the NDA with respect to such
Licensed Product for such indication in the applicable regulatory jurisdiction. 

  
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 1.44 “Initiate” means, with respect to a Clinical Trial, the first
date that a subject or patient is dosed in such Clinical Trial. 
 1.45 “INS” has the meaning set forth
in the Preamble. 
 1.46 “INS Know-How” means all Information Controlled by INS or any of its Affiliates
as of the Effective Date or at any time during the term of this Agreement to the extent such Information or any portion thereof could be considered infringed or misappropriated by the practice of the OX1 Technology, absent the license granted herein
whether or not patented or patentable, but excluding any Information to the extent covered or claimed by published INS Patents. 

1.47 “INS Patents” means all of the Patents that are Controlled by INS or any of its Affiliates as of the
Effective Date or at any time during the term of this Agreement to the extent such Patents include one or more Valid Claims which would be infringed by the practice of the OX1 Technology, absent the license granted herein. Without limitation of the
foregoing, the INS Patents shall include those Patents listed on Schedule 1.47, and any substitutions, divisions, continuations, continuations-in-part, reissues, renewals, registrations, confirmations, re-examinations, extensions,
supplementary protection certificates, and any international or foreign equivalent of any Patent listed in such Schedule. 

1.48 “INS Technology” means the INS Know-How and the INS Patents. 

1.49 “Invoiced Sales” has the meaning set forth in Section 1.57. 

1.50 “Knowledge” means the good faith understanding of any vice president, any senior vice president, or the
president or chief executive officer of a Party of the facts and information then in such individual’s possession and, *** and ***, after due inquiry. 
 1.51 “Labeling” means, with respect to a Licensed Product and country or regulatory jurisdiction, (a) the Regulatory Authority-approved full prescribing information for such
Licensed Product for such country, including any required patient information and (b) all labels and other written, printed or graphic matter upon a container, wrapper or otherwise, including any package insert, utilized with or for the
marketing, sale or other Commercialization of such Licensed Product in such country. 
 1.52 “Licensed
Product” means any form or dosage of pharmaceutical, biological or other composition or preparation in finished form labeled and packaged for sale by prescription, over-the-counter, as ***, as *** or by any other method that
(a) contains OX1 (including a product that contains OX1 together with one or more other ingredients (which may be either combined in a single formulation or bundled with separate formulations but sold as one product)); and (b) the
Development, Manufacture, Commercialization, or Exploitation of which utilizes or practices the OX1 Technology or any portion thereof. 
 1.53 “Listed Orphan Indication(s)” means each and any of the following: ***, and ***. 
 1.54 “Losses” has the meaning set forth in Section 11.1.1. 

  
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 1.55 “Manufacture” and “Manufacturing” means
all activities related to the production, manufacture, processing, formulation, filling, finishing, packaging, labeling, shipping, handling, holding, storage and warehousing of a Licensed Product or any intermediate thereof, including process
development, process qualification and validation, scale-up, pre-clinical, clinical and commercial manufacture and analytic development, product characterization, stability testing, quality assurance and quality control. 

1.56 “Mindset (USA)” has the meaning set forth in Section 10.3.6. 

1.57 “NDA” means a new drug application as defined in the FDC Act, and the regulations promulgated thereunder, or
any corresponding application for Regulatory Authorization in a country or jurisdiction other than the United States. 
 1.58
“Net Sales” shall mean, for any period, the gross amount invoiced by ViroPharma, its Sublicensees or any of its or their respective Affiliates for the sale or transfer of Licensed Products (the “Invoiced
Sales”), less deductions for: (a) normal and customary trade, quantity and cash discounts, credits, and sales returns and allowances, including (i) those granted on account of price adjustments, billing errors, rejected goods,
damaged goods and returns, (ii) administrative and other fees and reimbursements and similar payments actually made to wholesalers and other distributors, buying groups, pharmacy benefit management organizations, health care insurance carriers
and other customers or institutions in connection with the sale of Licensed Products, (iii) allowances, rebates and fees incurred on the sale of Licensed Product, and (iv) chargebacks; (b) freight, postage, shipping and insurance
expenses to the extent that such items are incurred on the sale of Licensed Product; (c) customs and excise duties and other duties related to the sales to the extent that such items are incurred on the sale of Licensed Product;
(d) rebates and similar adjustments made with respect to sales paid for by any governmental or regulatory authority; (e) sales and other taxes and duties directly related to the sale or delivery of Licensed Product(s) (but not including
taxes assessed against the income derived from such sale); (f) any other similar and customary deductions that are substantially similar to any of the foregoing; and (g) any such invoiced amounts that are not collected by ViroPharma, its
Sublicensees or any of its or their respective Affiliates; provided that such uncollected amount shall not exceed two percent (2%) of the invoiced amounts, less deductions under clauses (a) through (f) above. Deductions
pursuant to clause (g) above shall be taken in the Calendar Quarter in which the bad debt was recorded. For purposes of determining Net Sales, a Licensed Product shall be deemed to be sold when invoiced and a “sale” shall not include
transfers or dispositions of such Licensed Product for use in any pre-clinical experiment, research or in any Clinical Trial or as samples, in each case, without charge or for a de minimis charge. ViroPharma’s, any of its Sublicensee’s or
its or their respective Affiliate’s transfer of Licensed Product to an Affiliate or Sublicensee shall not result in any Net Sales, unless such Licensed Product is used by such Affiliate or Sublicensee in the course of its commercial activities.

 1.59 “NYU” means New York University. 

1.60 “Orphan Indication” means (a) a disease or condition that affects fewer than 200,000 people in the
United States or, if the drug is a vaccine, diagnostic drug, or preventive drug, the persons to whom the drug will be administered in the United States are fewer than 200,000 per year or (b) a disease or condition that meets the applicable
requirements of other Regulatory Authorities. 

  
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 1.61 “OX1” means: (a) 3-(3-indolyl) propionic acid or more
commonly indole-3-propionic acid or 3-IPA, including but not restricted to *** and ***, and *** and (b) ***. 
 1.62
“OX1 Technology” means (a) all chemical forms, compositions and methods of making OX1, and/or (b) all methods for the diagnosis, prevention and/or treatment of diseases and conditions, which methods employ OX1.

 1.63 “Party” and “Parties” has the meaning set forth in the Preamble.

 1.64 “Patents” means (a) all national, regional and international patents and patent
applications, including provisional patent applications, (b) all patent applications filed which are entitled to claim priority from such patents, patent applications or provisional applications, including divisionals, continuations,
continuations-in-part (other than with respect to new subject matter that would not otherwise be covered in this Agreement), provisionals, converted provisionals and continued prosecution applications, (c) any and all patents that have issued
or in the future issue from the foregoing patent applications ((a) and (b)), including utility models, petty patents and design patents and certificates of invention, and (d) any and all extensions or restorations by existing or future
extension or restoration mechanisms, including revalidations, reissues, re-examinations and extensions (including any supplementary protection certificates and the like) of the foregoing patents or patent applications ((a), (b) and (c)).

 1.65 “Payments” has the meaning set forth in Section 6.4.1. 

1.66 “Person” means an individual, sole proprietorship, partnership, limited partnership, limited liability
partnership, corporation, limited liability company, business trust, joint stock company, trust, unincorporated association, joint venture or other similar entity or organization, including a government or political subdivision, department or agency
of a government. 
 1.67 “Phase I Clinical Trial” means a human clinical trial of a Licensed Product,
the principal purpose of which is a preliminary determination of safety in healthy individuals or patients. A Phase I Clinical Trial shall be deemed to have commenced when the first patient in such study has been dosed. 

1.68 “Phase II Clinical Trial” means a human clinical trial of a Licensed Product, the principal purpose of which
is an initial determination of safety and efficacy in the target patient population. A Phase II Clinical Trial shall be deemed to have commenced when the first patient in such study has been dosed. 

1.69 “Phase III Clinical Trial” means a human clinical trial of a Licensed Product the purpose of which is to
establish the safety and efficacy of the Licensed Product for its intended use in the patient population for which it is intended and to serve as the basis for Regulatory Authorization. A Phase III Clinical Trial shall be deemed to have commenced
when the first patient in such study has been dosed. 

  
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 1.70 “Phase IV Clinical Trial” means a
post-registration human clinical trial conducted in any country or countries and required as a condition to, or for the maintenance of, any Regulatory Authorization for a Licensed Product. 

1.71 “Phase V Clinical Trial” means a post-registration human clinical trial conducted in any
country or countries and not required as a condition to, or for the maintenance of, any Regulatory Authorization for a Licensed Product in the Territory. For avoidance of doubt, such Phase V Clinical Trials are commonly referred to as
“marketing” Clinical Trials. 
 1.72 “Product Trademarks” means, with respect to a Licensed
Product, the Trademark(s) for such Licensed Product used by ViroPharma or its Affiliates or its or their respective Sublicensees on or in connection with such Licensed Product (but excluding any ViroPharma corporate name or similar designation) and
any registrations thereof or any pending applications relating thereto. 
 1.73 “Recalls” has the
meaning set forth in Section 8.2. 
 1.74 “Regulatory Authority” means any supra-national, federal,
national, regional, state, provincial or local regulatory agencies, departments, bureaus, commissions, councils or other government entity, including FDA, and notified authority regulating or otherwise exercising authority with respect to the
Exploitation (including the determination of pricing/reimbursement) of Licensed Products in any country or other jurisdiction. 

1.75 “Regulatory Authorization” means, with respect to a Licensed Product and country or regulatory jurisdiction,
any and all approvals, registrations, certificates, licenses or authorizations of any Regulatory Authority necessary to commercially distribute, sell or market or otherwise Commercialize such Licensed Product in such country or regulatory
jurisdiction, including, where applicable: (a) pricing or reimbursement approval in such country or regulatory jurisdiction; (b) pre- and post-approval manufacturing and marketing authorizations (including any prerequisite marketing
approval or authorization related thereto); (c) labeling approval; and (d) technical, medical and scientific licenses. 
 1.76 “Regulatory Documentation” means, with respect to any Licensed Product, all applications, registrations, licenses, authorizations and approvals, all correspondence submitted
to or received from the Regulatory Authorities (including minutes and official contact reports relating to any communications with any Regulatory Authority), and all supporting documents and all Clinical Trials and tests, in each case, relating to
the Licensed Product, and all data contained in any of the foregoing, including promotion documents, Clinical Data, period safety update reports, adverse event files and complaint files, Manufacturing records (including any chemistry, manufacturing
or control data) and, if applicable, any updates or supplements to any of the foregoing. 
 1.77 “SAMSF”
means the South Alabama Medical Science Foundation. 
 1.78 “Sublicensee” means a Person, other than an
Affiliate, that is granted a sublicense by ViroPharma under the license grants in Section 2.1, as provided in Section 2.2. 
 1.79 “Territory” means the entire world. 

  
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 1.80 “Third Party” means any Person other than INS, ViroPharma and
their respective Affiliates. 
 1.81 “Third Party Claims” has the meaning set forth in
Section 11.1.1. 
 1.82 “Trademark” shall include any word, name, symbol, color, designation or
device or any combination thereof, including any trademark, trade dress, brand mark, service mark, trade name, brand name, logo or business symbol, whether or not registered. 
 1.83 “United States” means the United States of America, its territories and possessions (including the District of Columbia and Puerto Rico). 

1.84 “Valid Claim” means, with respect to a particular country, (a) any claim of an issued and unexpired
Patent in such country that (i) has not been held permanently revoked, unenforceable or invalid by a decision of a court or governmental agency of competent jurisdiction, which decision is unappealable or unappealed within the time allowed for
appeal and (ii) has not been abandoned, disclaimed, denied or admitted to be invalid or unenforceable through reissue or disclaimer or otherwise in such country; or (b) a claim contained in a pending Patent application that was filed prior
to the Effective Date and is being prosecuted in good faith and has not been abandoned or finally disallowed without the possibility of appeal or re-filing of the application, provided that such prosecution has not been ongoing for more than
*** from the date such Patent application was filed. 
 1.85 “VAT” has the meaning set forth in
Section 6.4.2. 
 1.86 “ViroPharma” has the meaning set forth in the Preamble. 

1.87 “ViroPharma Improvements” has the meaning set forth in Section 7.1.2. 

1.88 “ViroPharma Know-How” means all Information (including ViroPharma Improvements and Clinical Data) Controlled
by or on behalf of ViroPharma, its Sublicensees or any of its or their respective Affiliates as of the Effective Date or at any time during the term of this Agreement that is used by or on behalf of ViroPharma, its Sublicensees or any of its or
their respective Affiliates, pursuant to this Agreement, in the development, commercialization or other Exploitation of Licensed Products, to the extent necessary or useful in the Exploitation of Licensed Products, whether or not patented or
patentable. 
 1.89 “ViroPharma Patents” means any Patent that claims or covers (a) any ViroPharma
Improvement or (b) any other Improvement that is conceived or reduced to practice, or that is otherwise Controlled (other than by virtue of the licenses granted hereunder), by or on behalf of ViroPharma, its Sublicensees or any of its or their
respective Affiliates under or in connection with the research, development, commercialization or other Exploitation of the Licensed Products and, in either case ((a) or (b)), is reasonably commercially relevant to the Exploitation of Licensed
Products. 
 1.90 “ViroPharma Technology” means ViroPharma Improvements, ViroPharma Know-How and
ViroPharma Patents. 

  
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 1.91 “Voting Stock” has the meaning set forth in
Section 1.18.1. 
 ARTICLE 2 
 GRANT OF RIGHTS; MAINTENANCE OF ACADEMIC LICENSE; COVENANT NOT TO COMPETE 

2.1 Grants to ViroPharma. 
 2.1.1. Subject to the terms and conditions of this Agreement, INS hereby grants to ViroPharma: 
 (a) an exclusive (including with regard to INS and its Affiliates), royalty-bearing right and license, with the right to grant sublicenses in accordance with Section 2.2, under the INS Technology
(excluding the INS Technology licensed to INS under the Academic License), to import, make, have made, use, sell, offer for sale, and otherwise Exploit Licensed Products in the Field in the Territory; 

(b) an exclusive (including with regard to INS and its Affiliates) right of reference, with the right to grant sublicenses and further
rights of reference in accordance with Section 2.2, under the Regulatory Documentation Controlled by INS or any of its Affiliates, if any, to Exploit the Licensed Products in the Field in the Territory; and 

(c) subject to the terms of the Academic License, an exclusive sublicense to the INS Technology licensed to INS under the Academic
License to import, make, have made, use, sell, offer for sale, and otherwise Exploit Licensed Products in the Territory. 
 2.2
Sublicenses. The rights and licenses granted to ViroPharma under Section 2.1 shall include the right to grant sublicenses (or further rights of reference), through multiple tiers of Sublicensees, provided that ViroPharma shall
provide to INS a written notice setting forth in reasonable detail the nature of such sublicense and the identity of the Sublicensee, unless such sublicenses are granted by ViroPharma in connection with Development activities or to Third Party
distributors, or other ordinary course Sublicensees, in which case no such notice shall be necessary. ViroPharma will assure that any Sublicensee at any tier shall be required to perform its obligations in a manner materially consistent with
ViroPharma’s obligations under this Agreement and the Academic License, and ViroPharma hereby guarantees the performance of its Affiliates and Sublicensees pursuant to the terms of such sublicense agreements; provided, however, the grant
of all such sublicenses shall not relieve ViroPharma of its obligations under this Agreement, except to the extent such obligations are satisfactorily performed by such Sublicensee. Any such sublicenses shall be consistent with and subject to the
terms and conditions of this Agreement in all material respects. 
 2.3 No Implied Rights; Reservation of Rights. For the
avoidance of doubt, as between the Parties: 
 2.3.1. ViroPharma, its Sublicensees and its and their respective Affiliates
shall have no right, express or implied, with respect to the INS Technology except as expressly provided in this Agreement; and 

  
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 2.3.2. INS and its Affiliates shall have no right, express or implied, with respect to the
ViroPharma Technology except as expressly provided in this Agreement. 
 2.3.3. The United States government retains rights in
intellectual property funded under any grant or similar contract with a Federal agency pursuant to 35 USC § 200-212. The sublicenses under the Academic License granted under Section 2.1.1(c) are expressly subject to all applicable United
States government rights. 
 2.4 Maintenance of the Academic License. Until the expiration or termination of this
Agreement: 
 2.4.1. INS shall not breach, or commit a default under the Academic License, which breach or default could give
rise, whether immediately or with the passage of time, to termination of the Academic License or to any restriction of INS’s rights thereunder in a manner that could adversely affect the rights granted by INS to ViroPharma under this Agreement.

 2.4.2. INS shall exercise all rights under the Academic License to preserve in full the value of such Academic License and
shall consult with ViroPharma in the event that any future action or failure to act by INS thereunder could adversely affect the rights granted by INS to ViroPharma under this Agreement. 

2.4.3. Without the prior consent of ViroPharma, INS shall not amend, terminate or allow to lapse the Academic License if such amendment,
termination or lapse could adversely affect the rights granted by INS to ViroPharma under this Agreement. 
 2.4.4. INS timely
shall cause NYU and/or SAMSF, as applicable, to send a copy of any notice or other communication under any Academic License asserting that INS is in breach of any provision thereunder to ViroPharma. In addition, in the event that INS receives any
such notice or other communication, INS shall promptly, and in any case within five (5) Business Days, notify ViroPharma of such notice or other communication. INS shall promptly remedy such breach or make such payment, failing which ViroPharma
shall have the right, at ViroPharma’s sole option, to pay any disputed amounts to NYU and/or SAMSF, as applicable, on behalf of INS and thereafter deduct one hundred percent (100%) of such amounts from any subsequent amounts due from
ViroPharma to INS under this Agreement, provided such right is in addition to any other rights or remedies ViroPharma may have under this Agreement. 
 2.5 Non-Compete. 
 2.5.1. During the term of this Agreement, except for
any activities undertaken in connection with the transfer of the OX1 Technology contemplated by Section 3.2.1, INS (or any successor or assign of INS) shall not, and shall not permit any of its Affiliates (or any successor or assign of any such
Affiliate) to, research, develop, market or sell (or enter into any license or sublicense arrangement with any Third Party to effect the foregoing) in the Field in any country in the Territory (a) any pharmaceutical or biological composition,
preparation or other type of product (including any over-the-counter product) that contains OX1 (including any such product that contains OX1 together with one or more other 

  
 13 

 
ingredients (which may be either combined in a single formulation or bundled with separate formulations but sold as one product)) and/or (b) any *** or *** that contains OX1 (including any
such product that contains OX1 together with one or more other ingredients (which may be either combined in a single formulation or bundled with separate formulations but sold as one product)). 

2.5.2. During the term of this Agreement, INS (or any successor or assign of INS) shall not, and shall not permit any of its Affiliates
(or any successor or assign of any such Affiliate) to, research, develop, market or sell (or enter into any license or sublicense arrangement with any Third Party to effect the foregoing) in the Field in any country in the Territory any
pharmaceutical or biological composition, preparation or other type of product (including any over-the-counter product) that is Developed for a Listed Orphan Indication. 
 2.5.3. If a court of competent jurisdiction determines that the restrictions set forth in this Section 2.5 are too broad or otherwise unreasonable under Applicable Law, including with respect to
duration, geographic scope or space, the court is hereby requested and authorized by the Parties hereto to revise the foregoing restriction to include the maximum restrictions allowable under Applicable Law. Each of the Parties hereto acknowledges,
however, that (a) this Section 2.5 has been negotiated by the Parties, (b) the geographical and time limitations on activities are reasonable, valid and necessary in light of the circumstances pertaining to the Parties and necessary
for the adequate protection of the Licensed Products, and (c) ViroPharma would not have entered in this Agreement without the protection afforded it by this Section 2.5. 

ARTICLE 3 

DEVELOPMENT 
 3.1 Development of Licensed Products. 
 3.1.1. ViroPharma shall use its
Commercially Reasonable Efforts on a continuous basis to Develop a Licensed Product for an Orphan Indication in *** and *** of *** in ***. As of the Effective Date, ViroPharma acknowledges that its current intent is to use its Commercially
Reasonable Efforts to Develop a Licensed Product for the treatment of Friedreich’s Ataxia, which intent may change from time to time. Without limiting the foregoing, ViroPharma shall (a) Initiate a Phase II Clinical Trial *** of the
Effective Date; provided, however, that *** to *** the *** of *** to Initiate the Phase II Clinical Trial *** shall *** a *** of this provision; and (b) *** to *** the *** and the *** to *** for *** from the *** in *** and from the ***;
and *** and ***, to ***; provided, however, that the provisions of this Section 3.1.1(b) are subject, ***, in the *** of *** under this Agreement, to *** of a *** to *** for a *** in *** and/or in ***. 

3.1.2. ViroPharma shall not be liable to INS for the failure to successfully develop Licensed Products and/or obtain Regulatory
Authorizations for Licensed Products in the Territory. 

  
 14 

 3.2 Technology and Materials Transfer; Introductions and Assistance. 

3.2.1. Technology Transfer. Without limiting the provisions of Section 3.1, promptly following the Effective Date, the
Parties shall coordinate a transfer to ViroPharma of the INS Technology set forth on Schedule 3.2.1. 
 3.2.2.
Materials Transfer. Promptly after the Effective Date, the Parties shall coordinate the transfer from INS to ViroPharma of the physical materials relating to Licensed Products set forth on Schedule 3.2.2. 

3.2.3. Introductions and Assistance.  
 (a) Promptly after the Effective Date, and at ViroPharma’s request, INS shall use its Commercially Reasonable Efforts to facilitate ViroPharma’s entry into manufacturing and/or other services
agreements with *** for the provision of services relating to the Development of the Licensed Products as desired by ViroPharma, it being understood and agreed between INS and ViroPharma that ViroPharma will not assume any liabilities or obligations
due and owing from INS to *** under the ***. In addition, INS will terminate the *** without, however, adversely affecting INS’s obligation to coordinate the transfer of physical materials pursuant to Section 3.2.2 and to perform its
obligations pursuant to Section 10.3.12. 
 (b) Promptly after the Effective Date, INS shall introduce ViroPharma to and,
at ViroPharma’s discretion, INS shall use its Commercially Reasonable Efforts to facilitate ViroPharma’s entry into commercial relationships with each of ***, and *** or any of their respective affiliates, as applicable, for the provision
of services relating to the Development of the Licensed Products as desired by ViroPharma, it being understood and agreed between INS and ViroPharma that ViroPharma will not assume any liabilities or obligations due and owing from INS to any of ***,
or *** or any of their respective affiliates, as applicable, under any existing relationships with such parties. 
 3.2.4.
Personnel Assistance.  
 (a) For a period of *** after the Effective Date, in addition to the transfer of INS Technology
contemplated by Section 3.2.1, INS shall make its personnel reasonably available, including by telephone, e-mail and through face-to-face meetings (which face-to-face meetings shall be conducted at ViroPharma’s reasonable request and
expense (for ***), to facilitate the transfer of INS’s OX1 program to ViroPharma. 
 (b) During such *** period,
ViroPharma shall compensate INS for all time requested by ViroPharma and spent by *** providing assistance requested by ViroPharma hereunder at the rate of US$*** per day or fraction thereof. 

(c) Following such *** period, ViroPharma and INS may mutually agree to extend the time period during which INS shall make ***
reasonably available, and ViroPharma may request *** assistance at a reasonable cost to be agreed upon by the Parties. 
 (d)
INS will submit invoices, or summaries of time spent (when services are provided at no charge), for services provided by INS personnel pursuant to this 

  
 15 

 
Section 3.2.4 to ViroPharma on a monthly basis, and each such invoice or summary of activities performed in response to ViroPharma’s request hereunder and the number of hours or days
spent performing each such activity. Invoices will be payable by ViroPharma within *** days after receipt thereof. 
 (e) In
addition to the foregoing, INS shall, at ViroPharma’s request, facilitate ViroPharma’s entry into consulting relationships with any of INS’s consultants identified by ViroPharma, including by not asserting any rights or claims that
INS may have under any consulting agreement to prohibit such consultants from working with third parties. 
 ARTICLE 4

 COMMERCIALIZATION 
 4.1 In General – Commercialization of Licensed Products. As between the Parties, ViroPharma shall have the sole right and obligation to Commercialize the Licensed Products in the Field in the
Territory at its own cost and expense in accordance with this Agreement. Without limitation of the foregoing, ViroPharma shall, and shall cause its Sublicensees and its and their respective Affiliates to use Commercially Reasonable Efforts to
Commercialize (a) at least one Licensed Product in the Field in *** following (i) the *** of *** for *** of *** in *** and (ii) *** pursuant to the *** at the *** of ***, the *** of *** for *** by the *** in *** with ***; and
(b) at least one Licensed Product in the Field in *** following (i) the receipt of all Regulatory Authorizations necessary for commercial sale of such Licensed Product in *** and (ii) *** pursuant to the *** at the *** of ***, the ***
of *** for *** by the *** in *** with the ***. 
 ARTICLE 5 

REGULATORY MATTERS 
 5.1 Regulatory Responsibilities. 
 5.1.1. For the avoidance of doubt,
ViroPharma’s rights under the licenses granted in Section 2.1 include the exclusive right to: 
 (a) obtain orphan
drug designation for Licensed Products from the FDA in accordance with 21 CFR 316 and from the applicable foreign Regulatory Authority in accordance with the applicable requirements administered by such Regulatory Authority, 

(b) implement Clinical Trials and related Development activities that are conducted in support of Regulatory Authorizations for Licensed
Products or Commercialization of Licensed Products, 
 (c) obtain and maintain Regulatory Authorizations for the Licensed
Products in the Field in the Territory, including all regulatory filings and applications for relevant Regulatory Authorizations, and 
 (d) prepare and deliver other communications with Regulatory Authorities in regard to the Development and Commercialization of Licensed Products in the Field in the Territory, including (i) all
correspondence submitted to Regulatory Authorities 

  
 16 

 
related to the design, conduct or results of non-clinical trials and Clinical Trials for Licensed Products, (ii) all correspondence submitted to Regulatory Authorities related to the
Manufacture of Licensed Products, (iii) all pricing and reimbursement approval proceedings relating to the Exploitation of any Licensed Product, (iv) all drug naming approval proceedings, and (v) all proposed Labeling; 

provided, however, that the foregoing list of rights does not constitute, and shall not be deemed to constitute, independent obligations of ViroPharma,
it being acknowledged and agreed that ViroPharma’s obligations with respect to the Development and Commercialization of Licensed Products are set forth, in their entirety, in Sections 3.1 and 4.1. 

5.1.2. Subject to Article 12, all Regulatory Authorizations and related submissions relating to Licensed Products in the Field in the
Territory shall be the property of ViroPharma and held in the name of ViroPharma. 
 ARTICLE 6 

CONSIDERATION 
 6.1 Payments to INS. In partial consideration of the licenses and other rights granted herein, ViroPharma shall make the following payments to INS: 

6.1.1. Up-Front Payment. ViroPharma shall pay a one-time patent license fee in the amount of Six Million Five Hundred Thousand
Dollars ($6,500,000) within *** days of the Effective Date of this Agreement. 
 6.1.2. Milestone Payments. ViroPharma
shall pay INS the following milestone payments on achievement by ViroPharma or any of its Affiliates or Sublicensees of each of the following milestones with respect to a Licensed Product during the term of this Agreement, within *** days after the
achievement of the relevant milestone, calculated as follows: 
 (a) upon the *** of *** by the *** in *** with ***, ***;

 (b) upon the *** of a *** of ***, ***; 
 (c) upon *** by ***, or one of its Affiliates, of the *** in ***, ***; 
 (d) upon
*** by ***, or one of its Affiliates, of the *** in ***, ***; and 
 (e) in the event that the *** in *** and the *** in either
*** or ***, then the *** in *** shall *** at ***, notwithstanding the fact that the *** in ***. 
 6.1.3. Milestones Payable
Only Once. Each specified milestone payment shall be payable only once, regardless of the number of times the corresponding milestone may be achieved. Accordingly, the aggregate amount of all milestone payments that may become due under
Section 6.1.2 is One Hundred Twenty Million Dollars ($120,000,000). 

  
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 6.1.4. Milestone Notice. ViroPharma shall notify INS within ten (10) Business
Days of any determination, completion or approval that would trigger a payment by ViroPharma to INS under Section 6.1.2 and the amount of the payment required and shall pay such amount as provided herein. 

6.2 Royalties. 
 6.2.1. In General. Subject to Section 6.2.3, ViroPharma shall pay to INS (or with respect to Section 6.2.1(c) directly to NYU and/or SAMSF at INS’s direction) a royalty on Net Sales
of the Licensed Products in an amount equal to the following percentages during each full or partial Calendar Year: 
 (a) ***
percent (***%) of the Net Sales of the Licensed Products in a Calendar Year up to *** Dollars ***; 
 (b) *** percent (***%) of
the Net Sales of the Licensed Products in a Calendar Year in excess of *** Dollars ***; and 
 (c) *** percent (***%) of the
Net Sales of the Licensed Products in a Calendar Year for the accounts of each of NYU and SAMSF, for an aggregate of *** of the Net Sales of the Licensed Products in a Calendar Year. 

6.2.2. Royalty Term. ViroPharma’s obligations to pay royalties under this Section 6.2 shall terminate with respect to
each Licensed Product, on a country-by-country basis (a) with respect to royalties payable pursuant to Sections 6.2.1(a) or 6.2.1(b), upon the later of (i) the *** anniversary of the First Commercial Sale of such Licensed Product in such
country and (ii) the first date on which there is no longer either (A) a Valid Claim of any INS Patent that would be infringed by the Exploitation of such Licensed Product in such country in the absence of the license grants hereunder, or
(B) any Data Exclusivity with respect to such Licensed Product in such country; and (b) with respect to royalties payable pursuant to Section 6.2.1(c), upon the expiry of the obligation to pay royalties pursuant to the Academic
License. Upon termination of the royalty obligations of ViroPharma under this Section 6.2 with respect to a Licensed Product in a particular country, the license grants to ViroPharma in Section 2.1 in respect of such Licensed Product in
such country shall become non-exclusive and fully paid-up with respect to such Licensed Product in such country. 
 6.2.3.
Royalty Step-Down. The royalties payable pursuant to Sections 6.2.1(a) and 6.2.1(b) shall be reduced by *** (***%) on a country-by-country basis during any period in which there (i) are no Valid Claims of any INS Patent that would be
infringed by the Exploitation of such Licensed Product in such country in the absence of the license grants hereunder, or (ii) is no Data Exclusivity with respect to such Licensed Product in such country. 

6.2.4. Royalty Payments. Running royalties shall be payable on a ***, within *** days after the end of each ***, based upon the
aggregate Net Sales in the Field in the Territory during such ***. Royalties shall be calculated in accordance with GAAP and with the terms of this Article 6. Only one royalty payment shall be due on Net Sales even though the sale or use of a
Licensed Product may be covered by more than one Patent in a country. 

  
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 6.2.5. Royalty Statements. Each royalty payment hereunder shall be accompanied by a
statement in sufficient detail to allow for the calculation of royalties due hereunder, including by showing, on a country-by-country basis, at a minimum, for the applicable Calendar Year (a) Invoiced Sales and Net Sales, (b) the number of
units of each Licensed Product sold in such country during such Calendar Year, (c) a detailed breakdown of any deductions from the Invoiced Sales to obtain Net Sales, and (d) the amount of royalties due on such Net Sales. 

6.2.6. Sublicense Revenue. For the avoidance of doubt, any and all Net Sales by Sublicensees shall be included in Net Sales
calculations for purposes of this Section 6.2 and ViroPharma shall pay INS the amount equal to the royalties that would have been owed by ViroPharma with respect to such Sublicensee sales had those sales been considered Net Sales by ViroPharma.

 6.3 Mode of Payment. All payments to INS under this Agreement shall be made by deposit of Dollars in the requisite
amount to such bank account as INS may from time to time designate by notice to ViroPharma. Payments shall be calculated using a currency exchange rate equal to the arithmetic mean of the daily exchange rates (obtained as described below) during the
applicable Calendar Year. Each daily exchange rate shall be obtained from the Reuters Daily Rate Report or The Wall Street Journal, Eastern Edition or, if not so available, as otherwise agreed by the Parties. 

6.4 Taxes.  
 6.4.1. INS alone shall be responsible for paying any and all taxes (other than withholding taxes required by Applicable Law to be paid by ViroPharma) levied on account of, or measured in whole or in part
by reference to, any payments it receives from ViroPharma relating to royalties, milestones, and other amounts payable by ViroPharma to INS pursuant to this Agreement (“Payments”). ViroPharma shall deduct or withhold from the
Payments any taxes that it is required by Applicable Law to deduct or withhold. Notwithstanding the foregoing, if INS is entitled under any applicable tax treaty to a reduction of rate of, or the elimination of, applicable withholding tax, it may
deliver to ViroPharma or the appropriate governmental authority (with the assistance of ViroPharma to the extent that this is reasonably required and is expressly requested in writing) the prescribed forms necessary to reduce the applicable rate of
withholding or to relieve ViroPharma of its obligation to withhold tax, and ViroPharma shall apply the reduced rate of withholding, or dispense with withholding, as the case may be, provided that ViroPharma has received evidence, in a form
reasonably satisfactory to ViroPharma, of INS’s delivery of all applicable forms (and, if necessary, its receipt of appropriate governmental authorization) at least fifteen (15) days prior to the time that the Payments are due. If, in
accordance with the foregoing, ViroPharma withholds any amount, it shall pay to INS the balance when due, make timely payment to the proper taxing authority of the withheld amount and send to INS proof of such payment within ten (10) days
following such payment. ViroPharma shall be responsible for any sales or other similar tax that INS may be required to collect with respect to the Payments. 
 6.4.2. Value Added Tax. Notwithstanding anything contained in Section 6.4.1, this Section 6.4.2 shall apply with respect to value added tax (“VAT”). All

  
 19 

 
Payments are exclusive of VAT. If any VAT is chargeable in respect of any Payments, ViroPharma shall pay VAT at the applicable rate in respect of any such Payments following the receipt of a VAT
invoice in the appropriate form issued by INS in respect of those Payments, such VAT to be payable on the later of the due date of the payment of the Payments to which such VAT relates and sixty (60) days after the receipt by ViroPharma of the
applicable invoice relating to that VAT payment. 
 6.5 Financial Records. ViroPharma shall, and shall cause its
Sublicensees and its and their respective Affiliates to, keep complete and accurate financial books and records pertaining to the Invoiced Sales (including any deductions therefrom) and Net Sales of Licensed Products in sufficient detail to
calculate the royalties and other amounts payable under this Agreement. Such books and records shall be retained by ViroPharma, its Sublicensees and its and their Affiliates, until the later of (a) three (3) years after the end of the
period to which such books and records pertain and (b) the expiration of the applicable tax statute of limitations (or any extensions thereof), or for such longer period as may be required by Applicable Law. 

ARTICLE 7 

INTELLECTUAL PROPERTY 
 7.1 Ownership of Intellectual Property. 
 7.1.1. Existing Rights.
Each Party shall remain the sole owner of any and all intellectual property rights, including any ownership or property rights in materials, owned by it at the Effective Date. 

7.1.2. Ownership of Improvements. Improvements which are made or generated exclusively by or on behalf of ViroPharma, its
Sublicensees or its or their respective Affiliates (“ViroPharma Improvements”) will be owned by ViroPharma. 
 7.2 Maintenance and Prosecution of Patents. 
 7.2.1. INS Patents.
INS shall have the first right, but not the obligation, to prepare, file, prosecute and maintain INS Patents and shall be responsible for related interference, re-issuance, re-examination and opposition proceedings; provided,
however, if INS plans to abandon any such Patent, INS shall notify ViroPharma in writing at least ninety (90) days in advance of the due date of any payment or other action that is required to prepare, file, prosecute or maintain such
Patent, and ViroPharma may elect, upon written notice within such ninety (90) day period to INS, to make such payment or take such action, at ViroPharma’s expense and in INS’s name, and INS shall reasonably cooperate with ViroPharma
in connection with such maintenance activities; provided, however, that control of the preparation, filing, prosecution and maintenance of Patents Controlled by INS pursuant to the Academic License is limited by the terms of the Academic License and
ViroPharma’s right to prepare, file, prosecute or maintain any INS Patent Controlled by INS pursuant to the Academic License is subject to approval by NYU or SAMSF (as applicable). Except as expressly permitted in this Section 7.2.1,
ViroPharma shall have no right to prepare, file, prosecute or maintain any INS Patent. 

  
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 7.2.2. ViroPharma Patents. ViroPharma shall have the first right, but not the
obligation, to prepare, file, prosecute and maintain ViroPharma Patents and shall be responsible for related interference, re-issuance, re-examination and opposition proceedings; provided, however, if ViroPharma plans to abandon any
such Patent, ViroPharma shall notify INS in writing at least ninety (90) days in advance of the due date of any payment or other action that is required to prepare, file prosecute or maintain such Patents, and INS may elect, upon written notice
within such ninety (90) day period to ViroPharma, to make such payment or take such action, at INS’s expense and in ViroPharma’s name, and ViroPharma shall reasonably cooperate with INS in connection with such maintenance activities.
Except as expressly permitted in this Agreement, INS shall have no right to prepare, file, prosecute or maintain any ViroPharma Patent. 
 7.3 Enforcement of Patents. 
 7.3.1. Notice. If any INS Patent or
any ViroPharma Patent is allegedly or actually infringed by a Third Party, the Party first having knowledge of such infringement shall promptly notify the other Party in writing. The notice shall set forth the facts of that infringement, as known by
the Party providing the notification, in reasonable detail. 
 7.3.2. INS Patents. INS shall have the first right, but
not the obligation, through counsel reasonably acceptable to ViroPharma, to control the prosecution of any infringement described in Section 7.3.1 relating to the INS Patents or, subject to the provisions of this Section 7.3.2, to grant
the infringing Third Party adequate rights and licenses necessary for continuing such activities; provided, however, that INS may not grant the infringing Third Party any right or license to Exploit Licensed Products in the Territory in the
Field without ViroPharma’s prior written consent, which shall not be unreasonably withheld; and provided, further, that prosecution of infringements of the INS Technology Controlled by INS pursuant to the Academic License is subject to
the terms of the Academic License. If INS does not initiate an infringement action within ninety (90) days (or twenty-five (25) days in the case of an action brought under the Hatch-Waxman Act or within the timeframe of any other relevant
regulatory or statutory framework that may govern) of learning of the infringement, or earlier notifies ViroPharma in writing of its intent not to so initiate an action, and INS has not granted such infringing Third Party rights and licenses to
continue its otherwise infringing activities, then ViroPharma shall have the right, but not the obligation, to bring such an action; provided, however, that the non-controlling Party shall have the right, at its own expense, to be
represented in any such action by counsel of its own choice. No settlement or consent judgment or other voluntary final disposition of a suit under this Section 7.3.2 may be entered into without the joint consent of INS and ViroPharma, such
consent not to be unreasonably withheld or delayed. On request of INS, ViroPharma shall join any such action as a party plaintiff. 
 7.3.3. ViroPharma Patents. ViroPharma shall have the first right, but not the obligation, through counsel reasonably acceptable to INS, to control the prosecution of any infringement described in
Section 7.3.1 relating to the ViroPharma Patents or, subject to the provisions of this Section 7.3.3, to grant the infringing Third Party adequate rights and licenses necessary for continuing such activities. If ViroPharma does not
initiate an infringement action within ninety (90) days (or twenty-five (25) days in the case of an action brought under the Hatch-Waxman Act or within the timeframe of any other relevant regulatory or statutory

  
 21 

 
framework that may govern) of learning of the infringement, or earlier notifies INS in writing of its intent not to so initiate an action, and ViroPharma has not granted such infringing Third
Party rights and licenses to continue its otherwise infringing activities, then INS shall have the right, but not the obligation, to bring such an action; provided, however, that the non-controlling Party shall have the right, at its
own expense, to be represented in any such action by counsel of its own choice. No settlement or consent judgment or other voluntary final disposition of a suit under this Section 7.3.3 may be entered into without the joint consent of INS and
ViroPharma, such consent not to be unreasonably withheld or delayed. 
 7.3.4. Enforcement Procedure. In the event a
Party is entitled to and brings an infringement action in accordance with this Section 7.3, the other Party shall cooperate fully, including furnishing of a power of attorney, being joined as a party plaintiff in such action, providing access
to relevant documents and other evidence and making its employees available at reasonable business hours. If a Party pursues an action against such alleged infringement, it shall consider in good faith any comments from the other Party and shall
keep the other Party reasonably informed of any steps taken to preclude such infringement. 
 7.3.5. Costs and Recovery.
Each Party shall *** relating to any enforcement action commenced pursuant to this Section 7.3. Any damages or other amounts collected shall be *** to *** the Party that *** to *** the *** for *** and *** in ***, and *** to *** the ***
Party for *** and *** in ***. Any remainder after such reimbursement is made shall be *** the *** to *** the *** of the *** under this Agreement with respect to the Licensed Products. If and to the extent required under the Academic License, ***
shall *** any *** it pursuant to the *** to *** and *** to *** the *** of *** and *** under *** of the ***. 
 7.4
Infringement Claims by Third Parties. 
 7.4.1. Defense of Third Party Claims. If a Third Party asserts that a
Patent or other intellectual property right (other than Trademarks, which shall be governed by Section 7.6) owned or controlled by it is infringed by the Exploitation of the INS Technology, the Party first obtaining knowledge of such a claim
shall immediately provide the other Party notice of such claim along with the related facts in reasonable detail. ViroPharma shall have the first right, but not the obligation, through counsel reasonably acceptable to INS, to control the defense of
any such claim. If ViroPharma does not accept control of the defense of such claim within ninety (90) days (or twenty-five (25) days in the case of an action brought under the Hatch-Waxman Act or within the timeframe of any other relevant
regulatory or statutory framework that may govern) of learning of the claim, or earlier notifies INS in writing of its intent not to so assume control of such defense, then INS shall have the right, but not the obligation, to defend against such
claim; provided, however, that the non-controlling Party shall have the right, at its own expense, to be represented in any such action by counsel of its own choice. 

7.4.2. Settlement of Third Party Claims. The Party that controls the defense of a given claim shall also have the right to
control settlement of such claim; provided, however, that (a) no settlement shall be entered into by such controlling Party without the prior written consent of the non-controlling Party if such settlement would adversely affect
or diminish the rights and benefits of the non-controlling Party under this Agreement or impose 

  
 22 

 
any new obligations or adversely affect any obligations of the non-controlling Party under this Agreement and (b) the controlling Party shall not be entitled to settle any such Third Party
claim by granting a license or covenant not to sue under or with respect to the non-controlling Party’s intellectual property rights without the prior written consent of the non-controlling Party, not to be unreasonably withheld or delayed.

 7.4.3. Allocation of Costs. Each Party shall bear its own costs and expenses relating to any defense pursuant to this
Section 7.4. Any damages or other amounts collected shall be first allocated to reimburse the Party that has exercised its right to control the defense of the claim for its costs and expenses in making such recovery, and second to reimburse the
other Party for its costs and expenses in making such recovery. Any remainder after such reimbursement is made shall be *** the *** to *** the *** of *** under this Agreement with respect to the Licensed Products. If and to the extent required under
the Academic License, *** shall *** any *** it pursuant to the *** to *** and *** in accordance with *** of the ***. 

7.4.4. Assistance. Each Party shall provide to the other Party all reasonable assistance requested by the other Party in
connection with any action, claim or suit under this Section 7.4, at the requesting Party’s expense, including allowing such other Party access to the assisting Party’s files and documents and to the assisting Party’s personnel
who may have possession of relevant information. In particular, the assisting Party shall promptly make available to the other Party all information in its possession or control that it is aware shall assist the other Party in responding to any such
action, claim or suit. 
 7.5 Invalidity or Unenforceability Defenses or Actions.  

7.5.1. Third Party Defense or Counterclaim. If a Third Party asserts, as a defense or as a counterclaim in any infringement
action under Section 7.3, that any INS Patent or ViroPharma Patent is invalid or unenforceable, then the Party pursuing such infringement action shall promptly give written notice to the other Party. With respect to the INS Patents, INS shall
have the first right, but not the obligation, through counsel reasonably acceptable to ViroPharma, to respond to such defense or defend against such counterclaim (as applicable) and, if ViroPharma (or its Sublicensees or any of its or their
respective Affiliates) is pursuing the applicable infringement action under Section 7.3, ViroPharma (or its Sublicensees or any of its or their respective Affiliates) shall allow INS to control such response or defense (as applicable)
provided, that control of the defense of the INS Technology Controlled by INS pursuant to the Academic License is subject to the terms of the Academic License. With respect to the ViroPharma Patents, ViroPharma shall have the first right, but
not the obligation, through counsel reasonably acceptable to INS, to respond to such defense or defend against such counterclaim (as applicable) and, if INS is pursuing the applicable infringement action under Section 7.3, INS shall allow
ViroPharma to control such response or defense (as applicable). Any costs and expenses with respect to such response or defense against such counterclaim shall be borne by the Party controlling such response or defense. If either Party (and such
Party’s licensors, to the extent permitted by its agreements therewith, and Sublicensees, if any) determines not to assume or fails to assume such defense within relevant timeframes, the other Party shall, at its sole cost and expense, have the
right to defend against such action or claim; provided, however, that such other Party shall obtain the written consent of INS, with respect to 

  
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the INS Patents, or ViroPharma, with respect to the ViroPharma Patents, prior to ceasing to defend, settling or otherwise compromising any such action or claim, such consent not to be
unreasonably withheld or delayed. 
 7.5.2. Third Party Declaratory Judgment or Similar Action. If a Third Party
asserts, in a declaratory judgment action or similar action or claim filed by such Third Party, that any INS Patent or ViroPharma Patent is invalid or unenforceable, then the Party first becoming aware of such action or claim shall promptly give
written notice to the other Party. With respect to the INS Patents, INS shall have the first right, but not the obligation, through counsel reasonably acceptable to ViroPharma, to defend against such action or claim provided, that control of
the defense of the INS Technology Controlled by INS pursuant to the Academic License is subject to the terms of the Academic License. With respect to the ViroPharma Patents, ViroPharma (or its Sublicensees or any of its or their respective
Affiliates) shall have the first right, but not the obligation, through counsel reasonably acceptable to INS, to defend against such action or claim. Any costs and expenses with respect to such defense shall be borne by the Party controlling such
response or defense. If either Party determines not to assume such defense or fails to assume such defense within forty-five (45) days (or twenty (20) days in the case of an action brought under the Hatch-Waxman Act or within the timeframe
of any other relevant regulatory or statutory framework that may govern) of learning of the action, the other Party shall, at its sole cost and expense, have the right to defend against such action or claim; provided, however, that
such other Party shall obtain the written consent of INS, with respect to the INS Patents, or ViroPharma, with respect to the ViroPharma Patents, prior to ceasing to defend, settling or otherwise compromising any such action or claim, such consent
not to be unreasonably withheld or delayed. 
 7.5.3. Assistance. Each Party shall provide to the other Party all
reasonable assistance requested by the other Party in connection with any action, claim or suit under this Section 7.5, at the requesting Party’s expense, including allowing such other Party access to the assisting Party’s files and
documents and to the assisting Party’s personnel who may have possession of relevant information. In particular, the assisting Party shall promptly make available to the other Party all information in its possession or control that it is aware
would assist the other Party in responding to any such action, claim or suit. 
 7.6 Third Party Licenses. If the
Exploitation of INS Technology by ViroPharma, its Sublicensees or any of its or their respective Affiliates hereunder infringes or misappropriates any Patent or other intellectual property right of a Third Party in any country, such that ViroPharma,
its Sublicensees or any of its or their respective Affiliates cannot Exploit INS Technology in such country as permitted hereunder without infringing the Patent or intellectual property right of such Third Party, then ViroPharma (or its Sublicensees
or any of its or their respective Affiliates) shall have the first right, but not the obligation, to take the lead in negotiating the terms of an appropriate license from such Third Party, provided that if ViroPharma (or its Sublicensees or
any of its or their respective Affiliates) does not take such lead, then INS may do so; provided further, that the negotiating Party shall obtain the written consent of such other Party prior to entering into any such license, such consent
not to be unreasonably withheld or delayed. Irrespective of the Party that actually obtains such license, *** to *** it *** to *** pursuant to *** the *** of (a) *** (i) ***, (ii) *** to ***, and (iii) the *** of *** to ***, in
each case ((i), (ii) and (iii)) *** and (b) *** or *** to *** and *** in *** of *** of ***, in each case ((a) and (b)) to *** to such *** in *** for the *** of a ***; provided, however that the *** of *** (***) of the *** to ***
pursuant to ***. 

  
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 7.7 Product Trademarks. 

7.7.1. Ownership of Product Trademarks. Subject to Article 12, as between the Parties, ViroPharma shall own and retain all right,
title and interest in and to the Product Trademarks. 
 7.7.2. Maintenance, Prosecution and Enforcement of Product
Trademarks. As between the Parties, ViroPharma (or its Sublicensees or any of its or their respective Affiliates) shall control the registration, prosecution, maintenance, enforcement and defense of the Product Trademarks. 

ARTICLE 8 

ADVERSE EVENT REPORTING; RECALLS AND WITHDRAWALS; 
 PROGRESS REPORTS 
 8.1 Adverse Event Reporting. 

8.1.1. Complaints. ViroPharma shall maintain a record of any and all complaints it receives with respect to Licensed Products.

 8.1.2. Adverse Event Reporting. ViroPharma shall be responsible for reporting adverse events in the Field in the
Territory to the Regulatory Authorities pursuant to Applicable Law. INS shall provide ViroPharma with all information in its possession necessary for ViroPharma to comply with its pharmacovigilance responsibilities in the Territory. 

8.1.3. Drug Safety Information. ViroPharma shall have the sole right to create and maintain a master drug safety database which
shall cross-reference any adverse event relating to a Licensed Product occurring anywhere in the Territory. ViroPharma shall be the sole owner of this master drug safety database. 

8.2 Recalls and Withdrawals. In the event that any Regulatory Authority orders or requests a recall, stop sale, field correction
or market withdrawal or takes similar action (collectively, “Recalls”) in connection with a Licensed Product or in the event ViroPharma determines that an event, incident or circumstance has occurred that may result in the
need for a Recall of a Licensed Product, ViroPharma shall promptly advise INS. ViroPharma shall decide whether to conduct any such Recall (except in the case of a government-mandated Recall) and the manner in which any such Recall shall be
conducted, and shall bear the expenses of any Recall. 
 8.3 Development and Commercialization Reports. ViroPharma shall
keep INS reasonably informed of the progress of its efforts to Develop and Commercialize Products. Without limiting the foregoing, ViroPharma shall, *** the *** of *** a *** to *** and *** the ***. 

  
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 8.4 Inspection Rights. No more than *** in any *** period and on reasonable advance
notice and during regular business hours, INS, NYU, SAMSF or their authorized representative shall each have the right to inspect the records and other relevant documentation of ViroPharma or of any Affiliate or Sublicensee engaged in the
Development, Manufacture, or Commercialization of Licensed Products insofar as they relate to Development, Manufacture, or Commercialization of Licensed Product, provided that the inspection of financial records will be governed by the terms of
Section 13.18.2. 
 ARTICLE 9 
 CONFIDENTIALITY AND NON-DISCLOSURE 
 9.1 Confidentiality Obligations.
At all times during the term and for a period of *** years following termination or expiration hereof, each Party shall, and shall cause its Affiliates and sublicensees and its and their respective officers, directors, employees and agents, and,
in addition, INS shall cause each of NYU and SAMSF, to, keep completely confidential and not publish or otherwise disclose and not use, directly or indirectly, for any purpose, any Confidential Information furnished or otherwise made known to it,
directly or indirectly, by the other Party, except to the extent such disclosure or use is expressly permitted by the terms of this Agreement or is reasonably necessary for the performance of this Agreement. “Confidential
Information” means any information provided by one Party to the other Party relating to the INS Technology, OX1, the Licensed Products (including any Regulatory Documentation and Regulatory Authorizations and any information or data
contained therein), any Development or Commercialization of the Licensed Products or the scientific, regulatory or business affairs or other activities of either Party and specifically includes the terms of this Agreement. Notwithstanding the
foregoing, Confidential Information shall not include any information that: 
 9.1.1. is or hereafter becomes part of the
public domain by public use, publication, general knowledge or the like through no wrongful act, fault or negligence on the part of the receiving Party; 
 9.1.2. can be demonstrated by documentation or other competent proof to have been in the receiving Party’s possession prior to disclosure by the disclosing Party without any obligation of
confidentiality with respect to said information; 
 9.1.3. is subsequently received by the receiving Party from a Third Party
who is not bound by any obligation of confidentiality with respect to said information; 
 9.1.4. has been published by a Third
Party (other than a sublicensee) or otherwise enters the public domain through no fault of the receiving Party in breach of this Agreement; or 
 9.1.5. can be demonstrated by documentation or other competent evidence to have been independently developed by or for the receiving Party without reference to the disclosing Party’s Confidential
Information. 
 Specific aspects or details of Confidential Information shall not be deemed to be within the public domain or in
the possession of the receiving Party merely because the Confidential 

  
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Information is embraced by more general information in the public domain or in the possession of the receiving Party. Further, any combination of Confidential Information shall not be considered
in the public domain or in the possession of the receiving Party merely because individual elements of such Confidential Information are in the public domain or in the possession of the receiving Party unless the combination and its principles are
in the public domain or in the possession of the receiving Party. 
 9.2 Trade Secrets. Notwithstanding the time
limitation provided in Section 9.1, Confidential Information that constitutes a trade secret under New York law or the Uniform Trade Secrets Act and is so identified to the receiving Party by the disclosing Party in writing shall be maintained
confidential indefinitely. 
 9.3 Permitted Disclosures. Each Party may disclose Confidential Information to the extent
that such disclosure is: 
 9.3.1. Made in response to a valid order of a court of competent jurisdiction or other
supra-national, federal, national, regional, state, provincial or local governmental or regulatory body of competent jurisdiction or, if in the reasonable opinion of the receiving Party’s legal counsel, such disclosure is otherwise required by
law; provided, however, that the receiving Party shall first have given notice to the disclosing Party and given the disclosing Party a reasonable opportunity to quash such order and to obtain a protective order requiring that the
Confidential Information and documents that are the subject of such order be held in confidence by such court or agency or, if disclosed, be used only for the purposes for which the order was issued; and provided further that if a disclosure
order is not quashed or a protective order is not obtained, the Confidential Information disclosed in response to such court or governmental order shall be limited to that information which is legally required to be disclosed in response to such
court or governmental order; 
 9.3.2. Made by the receiving Party to the Regulatory Authorities as required in connection with
any filing in relation to a Regulatory Authorization; provided, however, that reasonable measures shall be taken to assure confidential treatment of such information; 

9.3.3. Made by the receiving Party to its sublicensees or its or their respective Affiliates or by the receiving Party, its sublicensees
or its or their respective Affiliates to its or their respective attorneys, auditors, advisors, consultants, contractors, existing or prospective collaboration partners or licensees or other Third Parties as may be necessary or useful in connection
with the Manufacture or Exploitation of the Licensed Products or otherwise in connection with the performance of its obligations or exercise of its rights as contemplated by this Agreement; provided, however, that such Persons shall be
subject to obligations of confidentiality and non-use with respect to such Confidential Information substantially similar to the obligations of confidentiality and non-use of the receiving Party pursuant to this Article 9; provided further
that each Party shall remain responsible for any failure by its sublicensees or its or their respective Affiliates, attorneys, auditors, advisors, consultants, contractors, existing or prospective collaboration partners or licensees or other Third
Parties to treat such Confidential Information as required under this Article 9 (as if such sublicensees, Affiliates, attorneys, auditors, advisors, consultants, contractors, existing or prospective collaboration partners or licensees and other
Third Parties were Parties directly bound to the requirements of this Article 9). 

  
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 9.3.4. Made by the receiving Party to existing or potential acquirers or merger candidates;
investment bankers; or existing or potential investors, venture capital firms or other financial institutions or investors for purposes of obtaining financing, each of whom prior to disclosure must be bound by obligations of confidentiality and
non-use with respect to such Confidential Information substantially similar to the obligations of confidentiality and non-use of the receiving Party pursuant to this Article 9; provided, however, that INS shall make no such disclosure
to a Competitor, without obtaining ViroPharma’s prior consent in writing. 
 9.4 Use of Name. Neither Party shall
mention or otherwise use the name, insignia, symbol, Trademark, trade name or logotype of the other Party, NYU or SAMSF (or any abbreviation or adaptation thereof) in any publication, press release, marketing and promotional material or other form
of publicity without the prior written approval of such other Party, NYU or SAMSF, as applicable in each instance. The restrictions imposed by this Section shall not prohibit either Party from making any disclosure identifying the other Party
(a) as a counterparty to this Agreement to its investors, accountants and attorneys (b) that is required by Applicable Law or the requirements of a national securities exchange or another similar regulatory body (provided that any
such disclosure shall be governed by this Article 9), or (c) with respect to which consent has previously been obtained. Further, the restrictions imposed on each Party under this Section 9.4 are not intended, and shall not be construed,
to prohibit a Party from identifying the other Party in its internal business communications, provided that any Confidential Information in such communications remains subject to this Article 9. 

9.5 Press Releases. 
 9.5.1. The Parties shall agree on the form of the press releases for the public announcement of the execution of this Agreement and the Parties will cooperate in the releases thereof as soon as
practicable after the signature of this Agreement by the Parties. The Parties shall also agree on the contents of the Form 8-K and any other filings required by the Securities and Exchange Commission to be made by either Party. Press releases or
other similar public communication by ViroPharma relating to this Agreement, including upon termination of this Agreement by ViroPharma pursuant to Section 12.3, shall be approved in advance by INS, which approval shall not be unreasonably
withheld or delayed, except for those communications required by Applicable Law (provided that INS is given a reasonable opportunity to review and comment on any such press release or public communication in advance thereof), disclosures of
information for which consent has previously been obtained, information that has been previously disclosed publicly or as otherwise set forth in this Agreement. 
 9.5.2. Other than as set forth in Section 9.5.1, INS shall not issue any press release or other similar public communication relating to this Agreement, except for those communications required by
Applicable Law or as otherwise set forth in this Agreement. Notwithstanding the foregoing, INS may issue press releases or other similar public communications where (i) ViroPharma issues any such press release or public communication relating
to this Agreement and the INS press release or public communication includes 

  
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substantially the same information, (ii) INS shall be permitted to disclose on its website the existence of this Agreement and its general terms or (iii) a milestone payment set forth
in Section 6.1.2 has been made, provided, however, that ViroPharma is given a reasonable opportunity to review and comment on any such press release, website disclosure, or public communication in advance thereof. A Party may
further, subject to Section 9.3.4, (a) disclose the existence of this Agreement and (b) disclose the terms of this Agreement under obligations of confidentiality to such Party’s Affiliates, investors, prospective investors,
strategic partners, licensing partners, lenders, prospective lenders, acquirors, prospective acquirors, permitted sublicensees, prospective sublicensees, employees, consultants, agents and subcontractors in connection with such Party’s
activities hereunder and in connection with such Party’s financing activities. Without limiting the foregoing, the portion of any investor presentation prepared by a Party that includes the existence and terms of this Agreement shall be
approved in advance by the other Party prior to the presentation. The presenting Party shall not be required to obtain additional approval of a substantially similar presentation of the existence and terms of this Agreement following the approval
referenced in the preceding sentence. 
 9.6 Patient Information. The Parties agree to abide (and to cause their
respective Affiliates and sublicensees to abide) and to take (and to cause their respective Affiliates and sublicensees to take) all reasonable and appropriate actions to ensure that all Third Parties conducting or assisting with any clinical
development activities hereunder in accordance with, and subject to the terms of, this Agreement, shall abide, to the extent applicable, by all Applicable Law concerning the confidentiality or protection of patient identifiable information or
patient’s protected health information, including the regulations at 45 C.F.R. Parts 160 and 164 and where relevant, the applicable national laws implementing the European Parliament and Council Directive 95/46/EC on the protection of
individuals with regard to the processing of personal data and on the free movement of such data of 24 October 1995 and any other Applicable Law, in the course of their performance under this Agreement. 

9.7 Publications. INS recognizes that the publication of papers by ViroPharma regarding results of and other information regarding
activities under this Agreement, including oral presentations and abstracts, may be beneficial to both Parties, provided such publications are subject to reasonable controls to protect Confidential Information and avoid loss of potentially
patentable rights in Improvements. In particular, it is the intent of the Parties to maintain the confidentiality of any Confidential Information included in any Patent application until such Patent application has been filed. Accordingly, INS shall
have the right to review and approve any paper proposed for publication by ViroPharma, including any oral presentation or abstract, which includes INS’s Confidential Information. Before any such paper is submitted for publication or an oral
presentation is made, ViroPharma shall deliver a complete copy of the paper or materials for oral presentation to INS at least thirty (30) days prior to submitting the paper to a publisher or making the presentation. INS shall review any such
paper and give its comments to ViroPharma within twenty (20) days of the delivery of such paper to the other Party. With respect to oral presentation materials and abstracts, INS shall make reasonable efforts to expedite review of such
materials and abstracts, and shall return such items as soon as practicable to ViroPharma with appropriate comments, if any, but in no event later than twenty (20) days from the date of delivery to INS. Failure to respond within such twenty
(20) days shall be deemed approval to publish or present. If approval is not given or deemed given, ViroPharma may refer the Dispute in accordance with Section 13.7 for resolution. Notwithstanding the

  
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foregoing, ViroPharma shall comply with INS’s reasonable request to delete references to INS’s Confidential Information in any such paper and shall withhold publication of any such
paper or any presentation of same for an additional sixty (60) days in order to permit the Parties to obtain patent protection if either Party deems it necessary. Any publication shall include recognition of the contributions of the other
Party, and the contributions of Daniel Chain to the Development of Licensed Products, according to standard practice for assigning scientific credit, either through authorship or acknowledgement, as may be appropriate. For the avoidance of doubt,
INS shall not publish any paper, including any oral presentation or abstract, which contains Clinical Data or pertains to the results of Clinical trials or other studies relating to the Licensed Products and or the INS Technology or includes other
Information generated under this Agreement or which includes ViroPharma’s Confidential Information. 
 ARTICLE 10

 REPRESENTATIONS, WARRANTIES AND COVENANTS 
 10.1 Representations, Warranties and Covenants. Each Party hereby represents and warrants to the other Party as of the Effective Date as follows: 

10.1.1. Corporate Authority. Such Party (a) has the power and authority and the legal right to enter into this Agreement and
perform its obligations hereunder and (b) has taken all necessary action on its part required to authorize the execution and delivery of this Agreement and the performance of its obligations hereunder. This Agreement has been duly executed and
delivered by such Party and constitutes a legal, valid and binding obligation of such Party and is enforceable against it in accordance with its terms subject to the effects of bankruptcy, insolvency or other laws of general application affecting
the enforcement of creditor rights and judicial principles affecting the availability of specific performance and general principles of equity, whether enforceability is considered in a proceeding at law or in equity; 

10.1.2. Litigation. There is no pending or, to such Party’s Knowledge, threatened litigation (and such Party has not
received any communication) that alleges that such Party’s activities related to this Agreement have violated or that by conducting the activities as contemplated herein such Party would violate, any of the Patent, Trademark or other
intellectual property rights of any other Person; 
 10.1.3. Consents and Approvals. All necessary consents, approvals
and authorizations of all regulatory and governmental authorities and other Persons required to be obtained by such Party in connection with the execution and delivery of this Agreement and the performance of its obligations hereunder have been
obtained; and 
 10.1.4. Conflicts. The execution and delivery of this Agreement and the performance of such
Party’s obligations hereunder (a) do not conflict with or violate any requirement of Applicable Law or any provision of the articles of incorporation or bylaws of such Party in any material way and (b) do not conflict with, violate or
breach or constitute a default or require any consent under, any contractual obligation or court or administrative order by which such Party is bound. 

  
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 10.2 Additional Representations, Warranties and Covenants of ViroPharma. ViroPharma
represents, warrants and covenants to INS that: 
 10.2.1. (a) ViroPharma is a corporation duly organized and in good
standing under the laws of Delaware and (b) ViroPharma has full power and authority and the legal right to own and operate its property and assets and to carry on its business as it is now being conducted and as it is contemplated to be
conducted by this Agreement; and 
 10.2.2. Neither ViroPharma nor any of its Affiliates has been debarred or is subject to
debarment and neither ViroPharma nor any of its Affiliates will use in any capacity, in connection with the services to be performed under this Agreement, any Person who has been debarred pursuant to Section 306 of the FDC Act or who is the
subject of a conviction described in such section. ViroPharma shall inform INS in writing immediately if it or any Person who is performing services hereunder is debarred or is the subject of a conviction described in Section 306 or if any
action, suit, claim, investigation or legal or administrative proceeding is pending or, to the best of ViroPharma’s Knowledge, is threatened, relating to the debarment or conviction of ViroPharma or any Person performing services hereunder.

 10.3 Additional Representations, Warranties and Covenants of INS. INS represents, warrants and covenants to ViroPharma
that: 
 10.3.1. Each of Intellect Neurosciences and Intellect USA (a) is a corporation duly organized and in good
standing under the laws of Delaware and (b) has full power and authority and the legal right to own and operate its property and assets and to carry on its business as it is now being conducted and as is contemplated to be conducted by this
Agreement; 
 10.3.2. Intellect USA is a wholly-owned subsidiary of Intellect Neurosciences. Intellect owns all of the issued
and outstanding capital stock of Intellect USA free and clear of all security interests, liens, charges or encumbrances and Intellect USA has no outstanding options, warrants or rights to purchase capital stock or other securities of Intellect USA
other than the capital stock of Intellect USA owned by Intellect Neurosciences. Intellect Neurosciences has no subsidiaries other than Intellect USA. Intellect USA has no subsidiaries other than Intellect Neurosciences (Israel) Ltd.; 

10.3.3. Neither INS nor any of its Affiliates has been debarred or is subject to debarment and neither INS nor any of its Affiliates
will use in any capacity, in connection with the services to be performed under this Agreement, any Person who has been debarred pursuant to Section 306 of the FDC Act or who is the subject of a conviction described in such section. INS shall
inform ViroPharma in writing immediately if it or any Person who is performing services hereunder is debarred or is the subject of a conviction described in Section 306 or if any action, suit, claim, investigation or legal or administrative
proceeding is pending or, to the best of INS’s Knowledge, is threatened, relating to the debarment or conviction of INS or any Person performing services hereunder; 
 10.3.4. As of the Effective Date: (a)(i) INS Controls the INS Technology and is entitled to grant the licenses specified herein, (ii) the INS Patents are subsisting and are

  
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not invalid or unenforceable in whole or in part and (iii) INS’s right, title and interest in and to the INS Technology is free and clear of any liens, charges and encumbrances;
(b) the INS Patents listed on Schedule 1.47 are being procured from the respective Patent offices in accordance with Applicable Law; (c) *** actual infringement or threatened infringement of the INS Patents or any actual
misappropriation or threatened misappropriation of the INS Know-How by any Person; (d) there are no claims or litigation that have been brought and INS has no Knowledge of any claims or litigation that have been threatened by any Person
alleging that the INS Patents are invalid or unenforceable; and (e) *** Patent or other intellectual property right Controlled by a Third Party that would be infringed or misappropriated by ViroPharma’s Exploitation of the Licensed
Products in the Territory in the Field as contemplated hereby; 
 10.3.5. Intellect USA is the sole and exclusive licensee in
and to the INS Technology Controlled by INS pursuant to the Academic License, and INS is entitled to make the license grants set forth in Section 2.1 hereof. Schedule 10.3.5 to this Agreement is complete and accurate in all respects,
including INS’s claim of title to the Academic License; 
 10.3.6. The Asset Transfer Agreement between Mindset
Biopharmaceuticals (USA), Inc. (“Mindset (USA)”) and Intellect Neurosciences, Inc. (now Intellect USA, Inc.) dated June 22, 2005, and any related assignments (the “Asset Transfer Agreement”),
transferred and assigned to Intellect USA any and all right, title and interest in and to any OX1 Technology owned or Controlled by Mindset (USA) and all of its Affiliates, subsidiaries, and predecessors in interest, including Mindset Ltd.,
MindGenix, Inc., and Mindset Biopharmaceuticals, Ltd. INS has provided ViroPharma with a true and accurate copy of the Asset Transfer Agreement; 
 10.3.7. INS has provided ViroPharma a true and complete copy of the Academic License and all material correspondence between INS and NYU and/or SAMSF; including each Annual Report (as such term is defined
in the Academic License) provided pursuant to Section 6(c) of the Academic License and any and all notices required or permitted to be given to INS by NYU and/or SAMSF under the Academic License, and, (i) the Academic License is in full
force and effect in accordance with its terms; (ii) INS is in compliance in all material respects with its obligations under the Academic License; (iii) INS has not received notice that it is in breach of its obligations under the Academic
License; (iv) no term or provision of this Agreement constitutes or gives rise to, or shall constitute or give rise to, a breach of the Academic License; (vi) INS has not breached any material term of the Academic License; (vii) other
than the sublicense granted to ViroPharma pursuant to Section 2.1.1(c), INS has not granted and shall not grant any sublicenses under the Academic License; and (viii) there is no basis for termination of the Academic License; 

10.3.8. Except as explicitly included in the Academic License and in this Agreement, INS has not made any representation, warranty or
covenant to NYU or SAMSF regarding INS’s, ViroPharma’s or any other Person’s efforts relating to the Development or Commercialization of Licensed Products; 
 10.3.9. INS has provided ViroPharma, in a form acceptable to ViroPharma, written consents from NYU and SAMSF to the sublicense under the Academic License contemplated by this Agreement, which consents
include waivers from NYU and SAMSF of any past defaults by INS under the Academic License; 

  
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 10.3.10. All works of authorship and all other materials subject to copyright protection
included in INS Technology are original and were either created by INS employees or employees of a predecessor in interest to INS within the scope of their employment or are otherwise works made for hire, or all right, title and interest in and to
such materials have been validly and fully assigned and transferred to INS; 
 10.3.11. All rights in all inventions and
discoveries, made, developed or conceived by any employee or independent contractor of INS or of any predecessor in interest to INS during the course of employment (or other retention) by INS or any predecessor in interest to INS and relating to or
included in INS Technology have been validly and fully assigned and transferred to INS; 
 10.3.12. INS and its predecessors in
interest have worked with *** and its Affiliates (collectively, “***”) in connection with the manufacture of supplies for clinical use and testing of OX1, including stability testing, pursuant to two services agreements (collectively, with
other agreements, proposals, and ancillary documents, the “***”). In connection with the ***: (a) *** has manufactured certain physical materials including OX1 for INS and any payments for such materials have paid in full by INS and
INS holds title to such materials; (b) *** is storing the physical materials manufactured by *** set forth on Schedule 3.2.2 without charge for the benefit of INS; (c) INS owns all Information created in connection with the *** and
the sole extant deliverable is one stability report held by *** for which INS shall make payment to *** promptly following receipt of the up-front payment pursuant to Section 6.1.1 thereby entitling INS to receipt of such report and INS shall
deliver such report to ViroPharma promptly upon receipt; and (d) to the extent that *** developed any inventions, improvements or know-how in the course of the ***, *** has retained no interest in such inventions, improvements or know-how, INS
is the sole owner of such inventions, improvements or know-how and such inventions, improvements or know-how are included in the INS Know-How; 
 10.3.13. (a) As of the Effective Date, INS has caused any security interest, lien, charge or encumbrance on any INS securities secured in whole or in part by INS’s assets, including the INS
Technology and INS’s rights under the Academic License to be discharged and has provided to ViroPharma sufficient documentary evidence of same; and (b) INS shall not, and shall not permit any Affiliate to, create any security interest,
lien, charge or encumbrance on any part of the INS Technology, INS’s rights under the Academic License or this Agreement; 

10.3.14. All data and other information provided by INS and its agents in connection with ViroPharma’s due diligence investigation
of this transaction was, to INS’s Knowledge, genuine and did not contain any untrue statement of a material fact or omit to state a material fact necessary in order to make the statements made not misleading; 

  
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 10.3.15. INS has provided ViroPharma with complete and accurate copies of all Regulatory
Documentation relating to any Licensed Product, including all Regulatory Documentation filed with or delivered to any Regulatory Authority to date; 
 10.3.16. INS has title free and clear of any liens, charges and encumbrances to the INS Technology and to the Information, including Clinical Data, pre-clinical data and reports, and materials set forth
in Schedules 3.2.1 and 3.2.2; 
 10.3.17. INS owns all Clinical Data arising from each of the Phase I Clinical
Trials conducted by *** and the sole extant deliverable due from *** is the final report and associated certifications for the *** for which INS shall make payment to *** promptly following receipt of the up-front payment pursuant to
Section 6.1.1 thereby entitling INS to receipt of such report and INS shall deliver such report to ViroPharma promptly upon receipt; 
 10.3.18. INS owns all Information arising from the ***, conducted by *** and the sole extant deliverable due from *** is the final report and any associated certifications for such study for which INS
shall make payment to *** promptly following receipt of the up-front payment pursuant to Section 6.1.1 thereby entitling INS to receipt of such report and INS shall deliver such report to ViroPharma promptly upon receipt; and 

10.3.19. INS owns all Information arising from the *** conducted by an affiliate of *** and the sole extant deliverable due from such
affiliate of *** is the final report for the twenty-four month pull conducted by such affiliate of *** for which INS is entitled to receipt and INS shall deliver such report to ViroPharma promptly upon receipt. 

10.4 Offset. 
 10.4.1. If and to the extent that INS breaches any of the representations, warranties or covenants set forth in Sections *** and *** and ViroPharma can take reasonable action to remedy such breach and
restore ViroPharma to the position it would have been in had such INS breach not occurred and receive the full benefit of the bargain hereunder, then ViroPharma shall have the right, in addition to any other rights or remedies ViroPharma may have
under this Agreement, to take such action and offset all reasonable payments to third parties related to such remedy, including attorneys’ fees, from any amounts due from ViroPharma to INS under this Agreement, provided that ViroPharma complies
with the provisions of Section 10.4.2 when it exercises such rights. 
 10.4.2. If and to the extent that ViroPharma
indemnifies any Academic Indemnitee pursuant to Section 11.1.2 for Academic Losses arising as a result of or relating to INS’s action or omission under the Academic License, then ViroPharma shall have the right, in addition to any other
rights or remedies ViroPharma may have under this Agreement, to offset all payments to such Academic Indemnitee, in addition to ViroPharma’s reasonable attorneys’ fees, from any amounts due from ViroPharma to INS under this Agreement,
provided that ViroPharma complies with the provisions of Section 10.4.3 when it exercises such rights. 
 10.4.3. Upon a
determination by ViroPharma that it wishes to exercise the rights set forth in Section 10.4.1 or 10.4.2, ViroPharma shall, prior to the exercise of such rights: (a) provide INS with thirty (30) days’ prior written notice of
ViroPharma’s determination 

  
 34 

 
to exercise its right to offset and a reasonably detailed calculation thereof; (b) prior to or during such thirty (30) day period consult with INS, to the extent that INS makes itself
reasonably available, in good faith for the purpose of trying to resolve any dispute or incident relating thereto; and, only with respect to the rights set forth in Section 10.4.1, (c) prior to or during such thirty (30) day period,
unless waived in writing by INS, initiate litigation against INS alleging breach of any of the representations, warranties and/or covenants set forth in Sections *** and/or *** as applicable; and provided further, that the Parties shall have the
right to take the actions set forth in this Section 10.4 notwithstanding the provisions of Section 13.7. In the event that INS disputes a proposed offset amount and such proposed offset amount remains in dispute following good faith
consultation, ViroPharma shall reduce the next payments due under this Agreement by an amount not to exceed the amount so disputed and pay such disputed amount into an escrow account pursuant to an agreement with an escrow agent unrelated to either
Party and reasonably chosen by ViroPharma with instructions to dispose of the escrowed funds according to the final order resulting from the judicial proceeding thereon, or as subsequently agreed to by the Parties. 

10.5 Disclaimer of Warranty. EXCEPT FOR THE EXPRESS WARRANTIES SET FORTH IN SECTIONS 10.1, 10.2 AND 10.3, NEITHER PARTY MAKES ANY
REPRESENTATIONS OR GRANTS ANY WARRANTY, EXPRESS OR IMPLIED, EITHER IN FACT OR BY OPERATION OF LAW, BY STATUTE OR OTHERWISE, AND EACH PARTY SPECIFICALLY DISCLAIMS ANY OTHER WARRANTIES, WHETHER WRITTEN OR ORAL, OR EXPRESS OR IMPLIED, INCLUDING ANY
WARRANTY OF QUALITY, MERCHANTABILITY OR FITNESS FOR A PARTICULAR USE OR PURPOSE OR ANY WARRANTY AS TO THE VALIDITY OF ANY PATENTS OR THE NON-INFRINGEMENT OF ANY INTELLECTUAL PROPERTY RIGHTS OF THIRD PARTIES. WITHOUT LIMITING THE FOREGOING, INS MAKES
NO WARRANTY, EXPRESS OR IMPLIED, WITH RESPECT TO THE SUITABILITY OF ANY MATERIALS FOR USE IN CLINICAL TRIALS. 
 ARTICLE 11

 INDEMNIFICATION 
 11.1 Indemnification by ViroPharma.  
 11.1.1. ViroPharma shall indemnify
INS, its Affiliates and their respective directors, officers, employees and agents, and defend and save each of them harmless, from and against any and all losses, damages, liabilities, costs, fees and expenses (including reasonable attorneys’
fees and expenses) (collectively, “Losses”) in connection with any and all suits, actions, investigations, claims or demands of Third Parties (collectively, “Third Party Claims”) arising from or
occurring as a result of: (a) the breach by ViroPharma, its Sublicensees or any of its or their respective Affiliates of any representation, warranty, covenant, undertaking or other term contained in this Agreement; (b) the negligence or
willful misconduct on the part of ViroPharma, its Sublicensees or any of its or their respective Affiliates in performing its or their obligations under this Agreement; or (c) the Exploitation by ViroPharma, its Sublicensees or any of its or
their respective Affiliates of the Licensed Products, except in each case ((a), (b) and (c)) for those Losses for which INS has an obligation to indemnify ViroPharma pursuant to Section 11.2 hereof, as to which Losses each Party shall

  
 35 

 
indemnify the other to the extent of their respective responsibility for the Losses; provided, however, that ViroPharma shall not be obligated to indemnify INS for any Losses to the
extent that such Losses arise as a result of negligence or willful misconduct on the part of INS or any of its Affiliates or Sublicensees. 
 11.1.2. In addition, ViroPharma shall indemnify NYU and SAMSF and their trustees, officers, medical and professional staff, employees, students and agents and their respective successors, heirs and
assigns (the “Academic Indemnitees”) against any liability, damage, loss or expense (including reasonable attorneys’ fees and expenses of litigation) (“Academic Losses”) incurred or imposed upon
the Academic Indemnitees, as provided in the Academic License, substituting ViroPharma for INS under the Academic License, mutatis mutandis, with respect for such indemnification obligations, it being acknowledged and agreed, that ViroPharma
shall not be obligated to indemnify NYU or SAMSF for any Academic Losses for which INS has responsibility under the applicable Academic License or otherwise to the extent that such Academic Losses arise out of or relate to (a) events or
circumstances that occurred prior to the Effective Date, or (b) actions or omissions of INS, or its Affiliates or licensees or sublicensees, taken or omitted to be taken under the Academic License that are independent from this Agreement,
including any exploitation of any University Research Technology (as such term is defined in the Academic License) that is outside the scope of this Agreement and the exclusive sublicense granted by INS to ViroPharma under Section 2.1(c) of
this Agreement, including, for the avoidance of doubt, the *** and/or *** of the ***. 
 11.2 Indemnification by INS. INS
shall indemnify ViroPharma, its Affiliates and their respective directors, officers, employees and agents, and defend and save each of them harmless, from and against any and all Losses in connection with any and all Third Party Claims arising from
or occurring as a result of: (a) the breach by INS, its licensees or its sublicensees or any of its or their respective Affiliates of any representation, warranty, covenant, undertaking or other term contained in this Agreement; (b) the
negligence or willful misconduct on the part of INS, its licensees or its sublicensees or any of its or their respective Affiliates in performing its or their obligations under this Agreement; and/or (c) any actions or omissions of INS, or its
Affiliates or licensees or sublicensees, taken or omitted to be taken under the Academic License that are independent from this Agreement, including any exploitation of any University Research Technology (as such term is defined in the Academic
License) that is outside the scope of this Agreement and the exclusive sublicense granted by INS to ViroPharma under Section 2.1(c) of this Agreement, including, for the avoidance of doubt, the possible development and/or exploitation of the
compound melatonin, except in each case ((a) and (b)) for those Losses for which ViroPharma has an obligation to indemnify INS pursuant to Section 11.1 hereof, as to which Losses each Party shall indemnify the other to the extent of their
respective responsibility for the Losses; provided, however, that INS shall not be obligated to indemnify ViroPharma for any Losses to the extent that such Losses arise as a result of negligence or willful misconduct on the part of
ViroPharma or any of its Affiliates or Sublicensees. 
 11.3 Notice of Claim. All indemnification claims in respect of a
Party, its Affiliates or their respective directors, officers, employees and agents shall be made solely by such Party to this Agreement (the “Indemnified Party”). The Indemnified Party shall give the indemnifying Party
prompt written notice (an “Indemnification Claim Notice”) of any Losses or discovery of fact upon which such indemnified Party intends to base a request for 

  
 36 

 
indemnification under Section 11.1 or 11.2, but in no event shall the indemnifying Party be liable for any Losses that result from any delay in providing such notice. Each Indemnification
Claim Notice must contain a description of the claim and the nature and amount of such Loss (to the extent that the nature and amount of such Loss is known at such time). The Indemnified Party shall furnish promptly to the indemnifying Party copies
of all papers and official documents received in respect of any Losses and Third Party Claims. 
 11.4 Control of Defense.
Except as may be otherwise provided in the Academic License with respect to indemnification of NYU or SAMSF, the defense of any Third Party Claim shall be conducted as follows: 

11.4.1. Control by Indemnifying Party. At its option, the indemnifying Party may assume the defense of any Third Party Claim by
giving written notice to the Indemnified Party within thirty (30) days after the indemnifying Party’s receipt of an Indemnification Claim Notice. The assumption of the defense of a Third Party Claim by the indemnifying Party shall not be
construed as an acknowledgment that the indemnifying Party is liable to indemnify the Indemnified Party in respect of the Third Party Claim, nor shall it constitute a waiver by the indemnifying Party of any defenses it may assert against the
Indemnified Party’s claim for indemnification. Upon assuming the defense of a Third Party Claim, the indemnifying Party may appoint as lead counsel in the defense of the Third Party Claim any legal counsel selected by the indemnifying Party. In
the event the indemnifying Party assumes the defense of a Third Party Claim, the Indemnified Party shall immediately deliver to the indemnifying Party all original notices and documents (including court papers) received by the Indemnified Party in
connection with the Third Party Claim. Should the indemnifying Party assume the defense of a Third Party Claim, except as provided in Section 11.4.2, the indemnifying Party shall not be liable to the Indemnified Party for any legal expenses
subsequently incurred by such Indemnified Party in connection with the analysis, defense or settlement of the Third Party Claim. In the event that it is ultimately determined that the indemnifying Party is not obligated to indemnify, defend or hold
harmless the Indemnified Party from and against the Third Party Claim, the Indemnified Party shall reimburse the indemnifying Party for any and all costs and expenses (including attorneys’ fees and costs of suit) and any Third Party Claims
incurred by the indemnifying Party in its defense of the Third Party Claim. 
 11.4.2. Right to Participate in Defense.
Without limiting Section 11.4.1 above, any Indemnified Party shall be entitled to participate in, but not control, the defense of such Third Party Claim and to employ counsel of its choice for such purpose; provided, however,
that such employment shall be at the Indemnified Party’s own expense unless (a) the employment thereof has been specifically authorized by the indemnifying Party in writing, (b) the indemnifying Party has failed to assume the defense
and employ counsel in accordance with Section 11.4.1 (in which case the Indemnified Party shall control the defense) or (c) the interests of the indemnitee and the indemnifying Party with respect to such Third Party Claim are sufficiently
adverse to prohibit the representation by the same counsel of both Parties under Applicable Law, ethical rules or equitable principles. 
 11.4.3. Settlement. With respect to any Losses relating solely to the payment of money damages in connection with a Third Party Claim and that shall not result in

  
 37 

 
the Indemnified Party’s becoming subject to injunctive or other relief or otherwise adversely affecting the business of the Indemnified Party in any manner, and as to which the indemnifying
Party shall have acknowledged in writing the obligation to indemnify the Indemnified Party hereunder, the indemnifying Party shall have the sole right to consent to the entry of any judgment, enter into any settlement or otherwise dispose of such
Loss, on such terms as the indemnifying Party, in its sole discretion, shall deem appropriate. With respect to all other Losses in connection with Third Party Claims, where the indemnifying Party has assumed the defense of the Third Party Claim in
accordance with Section 11.4.1, the indemnifying Party shall have authority to consent to the entry of any judgment, enter into any settlement or otherwise dispose of such Loss, provided it obtains the prior written consent of the
Indemnified Party (which consent shall not be unreasonably withheld or delayed). The indemnifying Party shall not be liable for any settlement or other disposition of a Loss by an Indemnified Party that is reached without the written consent of the
indemnifying Party. Regardless of whether the indemnifying Party chooses to defend or prosecute any Third Party Claim, no Indemnified Party shall, and the Indemnified Party shall ensure that no indemnitee shall, admit any liability with respect to
or settle, compromise or discharge, any Third Party Claim without the prior written consent of the indemnifying Party, such consent not to be unreasonably withheld or delayed. 

11.4.4. Cooperation. Regardless of whether the indemnifying Party chooses to defend or prosecute any Third Party Claim, the
Indemnified Party shall, and shall cause each indemnitee to, cooperate in the defense or prosecution thereof and shall furnish such records, information and testimony, provide such witnesses and attend such conferences, discovery proceedings,
hearings, trials and appeals as may be reasonably requested in connection therewith. Such cooperation shall include access during normal business hours afforded to the indemnifying Party to, and reasonable retention by the Indemnified Party of,
records and information that are reasonably relevant to such Third Party Claim, and making indemnitees, employees and agents available on a mutually convenient basis to provide additional information and explanation of any material provided
hereunder, and the indemnifying Party shall reimburse the Indemnified Party for all its reasonable out-of-pocket expenses in connection therewith. 
 11.4.5. Expenses. Except as provided above, the costs and expenses, including fees and disbursements of counsel, incurred by the Indemnified Party in connection with any claim shall be reimbursed
on a Calendar Quarter basis by the indemnifying Party, without prejudice to the indemnifying Party’s right to contest the Indemnified Party’s right to indemnification and subject to refund in the event the indemnifying Party is ultimately
held not to be obligated to indemnify the Indemnified Party. 
 11.5 Limitation on Damages and Liability. EXCEPT IN
CIRCUMSTANCES OF INTENTIONAL MISCONDUCT BY A PARTY OR ITS AFFILIATES OR SUBLICENSEES (OR WITH RESPECT TO VIROPHARMA, ITS DISTRIBUTORS) OR WITH RESPECT TO THIRD PARTY CLAIMS UNDER SECTION 11.1 OR 11.2, NEITHER PARTY NOR ANY OF ITS AFFILIATES SHALL BE
LIABLE FOR SPECIAL, INDIRECT, INCIDENTAL OR CONSEQUENTIAL DAMAGES, OR FOR LOST PROFITS, MILESTONES OR ROYALTIES, WHETHER IN CONTRACT, WARRANTY, NEGLIGENCE, TORT, STRICT LIABILITY OR OTHERWISE, ARISING OUT OF (A) THE DEVELOPMENT, MANUFACTURE,
USE OR SALE OF THE LICENSED 

  
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PRODUCTS UNDER THIS AGREEMENT, (B) THE USE OF OR REFERENCE TO THE PATENTS, KNOW-HOW OR REGULATORY DOCUMENTATION LICENSED HEREUNDER OR (C) ANY BREACH OF OR FAILURE TO PERFORM ANY OF THE
PROVISIONS OF THIS AGREEMENT. 
 11.6 Insurance. Each Party shall maintain, at its sole cost and expense, an adequate
liability insurance or self-insurance program (including product liability insurance) to protect against potential liabilities and risk arising out of activities to be performed under this Agreement and any agreement related hereto and upon such
terms (including coverages, deductible limits and self-insured retentions) as are customary in the pharmaceutical industry generally for the activities to be conducted by such Party under this Agreement. Such liability insurance or self-insurance
program shall insure against all types of liability, including personal injury, physical injury or property damage arising out of the Exploitation of a Licensed Product. ViroPharma shall designate INS as an additional insured under its applicable
insurance policies and shall provide INS with a certificate of insurance evidencing such coverage. For such time as a sublicense of rights under the Academic License exists hereunder, ViroPharma will further comply with the insurance obligations of
the Academic License, substituting ViroPharma for INS, mutatis mutandis, with respect to such obligations. This Section 11.6 shall not create any limitation on a Party’s liability to the other under this Agreement. 

ARTICLE 12 

TERM AND TERMINATION 
 12.1 Term. This Agreement shall become effective on the Effective Date and, unless earlier terminated pursuant to Section 12.2, 12.3 or 12.4 hereof, shall continue on a Licensed
Product-by-Licensed Product and country-by-country basis until the expiration of the last royalty obligation with respect to such Licensed Product in such country pursuant to Sections 6.2.1 and 6.2.2. 

12.2 Termination for Material Breach. Any material failure by a Party (the “Breaching Party”) to comply
with any of its material obligations contained in this Agreement shall entitle the Party not in default to give to the Breaching Party written notice specifying the nature of the default, requiring the Breaching Party to make good or otherwise cure
such default, and stating its intention if such default is not cured to terminate this Agreement. If such default is not cured within *** days after the receipt of such notice (or, if such default cannot be cured within such *** day period, if the
Breaching Party does not commence actions to cure such default within such period and thereafter diligently continue such actions or if such default is not otherwise cured within *** days after the receipt of such notice, except in the case of a
payment default, as to which the Breaching Party shall have only a *** day cure period, provided, however, that such *** day cure period shall be stayed with respect to any portion of any payment default subject to a Dispute), the
Party not in default shall be entitled, on written notice to the Breaching Party, without prejudice to any other rights conferred on it by this Agreement, and in addition to any other remedies available to it at law or in equity, to terminate this
Agreement in its entirety. 
 12.3 Other Termination by ViroPharma. If ViroPharma determines, in its sole and absolute
discretion, that it is not feasible or desirable to pursue the Development or 

  
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Commercialization of Licensed Products contemplated by this Agreement, including (without thereby in any way limiting ViroPharma’s sole and absolute discretion) for scientific, technical,
regulatory or commercial reasons (including safety or efficacy reasons), reasons relating to the present or future marketability or profitability of such Licensed Products, or reasons relating to the identity of any successor to INS or relations
between ViroPharma and any such successor, then ViroPharma may, by written notice to INS, terminate this Agreement in its entirety upon *** days’ prior written notice to INS. 

12.4 Termination Upon Insolvency. Either Party may terminate this Agreement if, at any time, the other Party shall (a) file
in any court or agency pursuant to any statute or regulation of any state, country or jurisdiction a petition in bankruptcy or insolvency or for reorganization or for an arrangement or for the appointment of a receiver or trustee of such other Party
or of its assets, (b) propose a written agreement of composition or extension of its debts outside the ordinary course of its business, (c) be served with an involuntary petition against it, filed in any insolvency proceeding, and such
petition shall not be dismissed within sixty (60) days after the filing thereof, (d) propose or be a party to any dissolution or liquidation, (e) make an assignment for the benefit of its creditors, or (f) admit in writing its
inability generally to meet its obligations as they fall due in the general course. 
 12.5 Rights in Bankruptcy. All
rights and licenses granted under or pursuant to this Agreement by INS or ViroPharma are, and shall otherwise be deemed to be, for purposes of Section 365(n) of the United States Bankruptcy Code, licenses of rights to “intellectual
property” as defined under Section 101 of the United States Bankruptcy Code. The Parties agree that the Parties, as licensees of such rights under this Agreement, shall retain and may fully exercise all of their rights and elections under
the United States Bankruptcy Code. The Parties further agree that, in the event of the commencement of a bankruptcy proceeding by or against a Party under the United States Bankruptcy Code, the Party hereto that is not a party to such proceeding
shall be entitled to a complete duplicate of (or complete access to, as appropriate) any such intellectual property and all embodiments of such intellectual property, which, if not already in the non-subject Party’s possession, shall be
promptly delivered to it (a) following any such commencement of a bankruptcy proceeding upon the non-subject Party’s written request therefor, unless the Party subject to such proceeding continues to perform all of its obligations under
this Agreement or (b) if not delivered under clause (a) above, following the rejection of this Agreement by or on behalf of the Party subject to such proceeding upon written request therefor by the non-subject Party. 

12.6 Licenses and Assignments Upon Termination (but Not Expiration). Except as provided below in this Section 12.6, upon any
termination of this Agreement: 
 12.6.1. the licenses granted by INS to ViroPharma under Section 2.1 shall terminate in
their entirety; 
 12.6.2. Except with respect to ViroPharma’s termination of this Agreement under Section 12.2,
ViroPharma shall, and does hereby, grant, and shall cause its Sublicensees and its and their respective Affiliates to so grant, to INS, subject to any agreement existing as of the Effective Date between ViroPharma and any Third Party governing the
ViroPharma Technology, an exclusive, perpetual, irrevocable, worldwide, royalty-bearing 

  
 40 

 
(solely as provided in Section 12.7.6) license, with the right to grant sublicenses through multiple tiers of sublicensees, without the consent of ViroPharma, under the ViroPharma Technology
to Exploit the Licensed Products for all purposes; and 
 12.6.3. Subject to any agreement existing as of the Effective Date
between ViroPharma and any Third Party governing the ViroPharma Technology, ViroPharma shall, and does hereby, and shall cause its Sublicensees and its and their respective Affiliates to, transfer, convey, assign and deliver to INS, and INS hereby
accepts, all right, title and interest in and to, (a) the Licensed Products, including any related Information and inventions, and any Improvements with respect thereto (including ViroPharma Know-How and all material aspects of Confidential
Information Controlled by ViroPharma as of the date of termination with respect to the Licensed Products), (b) any Regulatory Authorizations and related Regulatory Documentation and correspondence with Regulatory Authorities with respect to any
Licensed Product, (c) any Product Trademarks, any other Trademarks (including any goodwill associated therewith), any generic names and any domain names incorporating the same that were used by, or developed for use by, ViroPharma in connection
with any Licensed Product and (d) to the extent requested by INS in writing, any agreements with any Third Parties with respect to any Licensed Product (including agreements with contract research organizations, clinical sites and
investigators). 
 12.7 Additional Consequences of Termination. 

12.7.1. Sale of Inventory. In the event of any termination of this Agreement, ViroPharma may continue to sell its existing
inventories and any work-in-process of Licensed Products until the occurrence of either: (a) ViroPharma’s completion of the transfer of all Regulatory Authorizations and related Regulatory Documentation for Licensed Products and completion
of performance under all then-existing contracts with Third Parties for the marketing, sale or manufacture of Licensed Products, or (b) INS’s directing ViroPharma to halt all sales of Licensed Products by written notice. If either such
event occurs prior to the sale of all of ViroPharma’s inventories and work-in-process of Licensed Products and the performance by ViroPharma of its obligations under such Third Party contracts, then ViroPharma shall ***, and INS shall *** and
*** and ***, and thereafter ***. 
 12.7.2. Return of INS Materials and Information. Except as reasonably required for
the exercise of its rights under the last sentence of Section 6.2.2, upon the expiration or any termination of this Agreement, ViroPharma, at the request of INS, shall return or, at the election of ViroPharma, use reasonable efforts to destroy,
and thereafter provide to INS written certification evidencing such destruction, all data, files, records and other materials in its possession or control relating to the INS Technology, or containing or comprising INS’s Information and
inventions or other Confidential Information (except one copy of which may be retained solely for archival purposes) with respect to the terminated Licensed Product(s). 
 12.7.3. Effect of Termination on Sublicenses Granted by ViroPharma. In the event that this Agreement is terminated pursuant to this Article 12, INS will grant to each Sublicensee a license of the
same rights under this Agreement conferred on the Sublicensee by the sublicense agreement on substantially those same terms and conditions 

  
 41 

 
as are contained in the applicable sublicense agreement, including the financial terms contained therein, provided that, at such time the Sublicensee is not in material breach of the applicable
sublicense agreement; and further provided that INS shall not be obligated to provide Development or any other support, including financial support, to any Sublicensee. Notwithstanding the foregoing, until such license is granted by INS, each
sublicense entered into by ViroPharma or any of its Affiliates with a Sublicensee pursuant to Section 2.2 shall survive the termination of this Agreement, except to the extent that any such Sublicensee under any such sublicense agreement is in
material breach of this Agreement or such sublicense agreement, in which case INS shall have the right to terminate any such sublicense agreement; and further provided that while such sublicense is in effect, to the extent that ViroPharma has agreed
under such sublicense to provide Development or other support, including financial support, to any such Sublicensee, such support obligations shall be suspended until such license is granted by INS. Notwithstanding any provision to the contrary, any
sublicense agreement entered into by ViroPharma with any of its Affiliates shall terminate upon the termination of this Agreement. 
 12.7.4. Milestone Payments; Royalties. Following any termination of this Agreement, ViroPharma shall not be responsible for (a) any milestone payments for milestone events that are achieved
under Section 6.1.2 following the effective date of such termination or (b) any royalty payments that accrue under Section 6.2 following the effective date of such termination, except in each case ((a) and (b)) with respect to any
sales of Licensed Products made by ViroPharma, either itself or through an Affiliate, Sublicensee or Sublicensee’s Affiliate, pursuant to Section 12.7.1. 
 12.7.5. Assistance. Without limiting INS’s rights under other provisions of this Article 12, in the event of any termination of this Agreement, ViroPharma shall, and shall cause its
Sublicensees and its and their respective Affiliates to, at the request and expense of INS, provide INS with such assistance as is reasonably necessary to effectuate a smooth and orderly transition of any such Development, Commercialization and
other Exploitation activities, including any ongoing Clinical Trials, to INS or its designee so as to minimize any disruption of such activities. 
 12.7.6. Royalties to ViroPharma. In consideration of the license rights granted by ViroPharma to INS under this Article 12 and the assignment of Regulatory Authorizations and related Regulatory
Documentation as contemplated by this Article 12, INS shall pay to ViroPharma for each Licensed Product sold by INS, its (sub)licensees or its or their respective Affiliates anywhere in the world a royalty of *** (***) of Net Sales (substituting INS
for ViroPharma in the definition thereof) during each full or partial Calendar Year following termination of this Agreement; provided, however, that INS’s obligation to pay royalties under this Section 12.7.6 shall terminate after the
aggregate royalties paid under this Section 12.7.6 shall equal the sum of (a) all payments made by ViroPharma and its Sublicensees pursuant to Sections 6.1.1 (Up-Front Payment), 6.1.2 (Milestone Payments), and 6.2 (Royalties) prior to
termination of this Agreement and (b) all documented Development expenses incurred by ViroPharma, its Affiliates or Sublicensees in connection with the Development of Licensed Product prior to termination of this Agreement. Subject to the
royalties for which provision is made in the preceding sentence, such Net Sales shall be the absolute property of INS. The royalties contemplated by this Section 12.7.6 shall be payable by INS to ViroPharma in accordance with the provisions of
Sections 6.2.4, 6.2.5, and 6.2.6, mutatis mutandis and Section 13.18. 

  
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 12.7.7. Accrued Rights. Termination or expiration of this Agreement for any reason
shall be without prejudice to any rights that shall have accrued to the benefit of a Party prior to such termination or expiration. Such termination or expiration shall not relieve a Party from obligations that are expressly indicated to survive the
termination or expiration of this Agreement. 
 12.7.8. Survival. Without limiting the foregoing, Sections 2.3, 6.2.2,
6.3, 6.4, 6.5, 7.1, Article 8 (in respect of Licensed Product sold prior to the expiration or termination of this Agreement or pursuant to Section 12.7.1), Article 9, Sections 10.4 and 10.5, Article 11, this Article 12, and Sections 13.3, 13.4,
13.5, 13.6, 13.7, 13.8, 13.9, 13.10, 13.11, 13.12, 13.13, 13.14, 13.15, 13.18, 13.19 and 13.20 of this Agreement shall survive the termination or expiration of this Agreement for any reason. 

ARTICLE 13 

MISCELLANEOUS 
 13.1 Force Majeure. Neither Party shall be held liable or responsible to the other Party or be deemed to have defaulted under or breached this Agreement for failure or delay in fulfilling or
performing any term of this Agreement (other than an obligation to make payments) when such failure or delay is caused by or results from events beyond the reasonable control of the non-performing Party, including fires, floods, earthquakes,
embargoes, shortages, epidemics, quarantines, war, acts of war (whether war be declared or not), terrorist acts, insurrections, riots, civil commotion, strikes, lockouts or other labor disturbances (whether involving the workforce of the
non-performing Party or of any other Person), acts of God or acts, omissions or delays in acting by any governmental authority. The non-performing Party shall notify the other Party of such force majeure within thirty (30) days after such
occurrence by giving written notice to the other Party stating the nature of the event, its anticipated duration, and any action being taken to avoid or minimize its effect. The suspension of performance shall be of no greater scope and no longer
duration than is necessary and the non-performing Party shall use commercially reasonable efforts to remedy its inability to perform. In the event that such force majeure event lasts for more than ninety (90) days, such suspension of
performance shall be deemed a material breach of this Agreement and such other Party shall have the right to terminate this Agreement pursuant to Section 12.2. 
 13.2 Change in Control. 
 13.2.1. Either Party (or its successor)
shall provide the other Party with written notice of any Change in Control of such Party within two (2) Business Days following the closing date of such transaction. 
 13.2.2. In the event the Change in Control of INS or Acquisition involving INS involves a Competitor, will result in INS controlling, being controlled by, or being under common control with a Competitor,
or will result in INS or any Person controlling, controlled by, or under common control with INS being involved in the Exploitation of (a) any 

  
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pharmaceutical or biological composition, preparation or other type of product (including any over-the-counter product) that (i) contains OX1 (including any such product that contains OX1
together with one or more other ingredients (which may be either combined in a single formulation or bundled with separate formulations but sold as one product)) and/or (ii) is Developed for any Listed Orphan Indication, and/or (b) any ***
or *** that contains OX1 (including any such product that contains OX1 together with one or more other ingredients (which may be either combined in a single formulation or bundled with separate formulations but sold as one product)), then ViroPharma
shall have the right, in its sole and absolute discretion, by written notice delivered to INS (or its successor) at any time during the one hundred eighty (180) days following the written notice contemplated by Section 13.2.1, to *** of
*** for *** to *** of *** to *** by *** for the ***. For clarity, all other provisions of this Agreement shall remain in full force and effect. 
 13.3 Export Control. This Agreement is made subject to any restrictions concerning the export of products or technical information from the United States or other countries that may be imposed on
related to the Parties from time to time. Each Party agrees that it will not export, directly or indirectly, any technical information acquired from the other Party under this Agreement or any products using such technical information to a location
or in a manner that at the time of export requires an export license or other governmental approval, without first obtaining the written consent to do so from the appropriate agency or other governmental entity in accordance with Applicable Law.

 13.4 Assignment. Without the prior written consent of the other Party hereto, neither Party shall sell, transfer,
assign, delegate, pledge or otherwise dispose of, whether voluntarily, involuntarily, by operation of law or otherwise, this Agreement or any of its rights or duties hereunder; provided, however, that either Party may, without such
consent, assign or transfer this Agreement or any of its rights and obligations hereunder to (a) an Affiliate of such Party; or (b) to any Third Party with which it merges or consolidates, or to which it transfers all or substantially all
of its assets to which this Agreement relates if in any such event (i) the assigning Party (provided that it is not the surviving entity) remains jointly and severally liable with the relevant Affiliate or Third Party assignee under this
Agreement, and (ii) the relevant Affiliate assignee, Third Party assignee or surviving entity assumes in writing all of the assigning Party’s obligations under this Agreement. Any attempted assignment or delegation in violation of the
preceding sentence shall be void and of no effect. All validly assigned and delegated rights and obligations of the Parties hereunder shall be binding upon and inure to the benefit of and be enforceable by and against the successors and permitted
assigns of INS or ViroPharma, as the case may be. In the event either Party seeks and obtains the other Party’s consent to assign or delegate its rights or obligations to another party, the assignee or transferee shall assume all obligations of
its assignor or transferor under this Agreement. Notwithstanding any provision in this Agreement to the contrary, there shall be no limitation or restriction on any assignment by ViroPharma of its rights under this Agreement as collateral to a
lender or financing or funding source or on any subsequent assignment by such assignee. 
 13.5 Severability. If any
provision of this Agreement is held to be illegal, invalid or unenforceable under any present or future law, and if the rights or obligations of either Party under this Agreement will not be materially and adversely affected thereby, (a) such
provision shall be fully severable, (b) this Agreement shall be construed and enforced as if such 

  
 44 

 
illegal, invalid or unenforceable provision had never comprised a part hereof, (c) the remaining provisions of this Agreement shall remain in full force and effect and shall not be affected
by the illegal, invalid or unenforceable provision or by its severance herefrom and (d) in lieu of such illegal, invalid or unenforceable provision, there shall be added automatically as a part of this Agreement a legal, valid and enforceable
provision as similar in terms to such illegal, invalid or unenforceable provision as may be possible and reasonably acceptable to the Parties. To the fullest extent permitted by applicable law, each Party hereby waives any provision of law that
would render any provision hereof illegal, invalid or unenforceable in any respect. 
 13.6 Governing Law, Jurisdiction,
Venue and Service. 
 13.6.1. Governing Law. This Agreement shall be governed by and construed in accordance
with the laws of the State of New York, excluding any conflicts or choice of law rule or principle that might otherwise refer construction or interpretation of this Agreement to the substantive law of another jurisdiction. The Parties agree to
exclude the application to this Agreement of the United Nations Convention on Contracts for the International Sale of Goods. 

13.6.2. Jurisdiction. Subject to Sections 13.7 and 13.11, the Parties hereby irrevocably and unconditionally consent to the
exclusive jurisdiction of the courts of the State of New York and the United States District Court for the Southern District of New York, in either case sitting in the Borough of Manhattan in the City of New York, for any action, suit or proceeding
(other than appeals therefrom) arising out of or relating to this Agreement, and agree not to commence any action, suit or proceeding (other than appeals therefrom) related thereto except in such courts. The Parties irrevocably and unconditionally
waive their right to a jury trial. 
 13.6.3. Venue. The Parties further hereby irrevocably and unconditionally waive
any objection to the laying of venue of any action, suit or proceeding (other than appeals therefrom) arising out of or relating to this Agreement in the courts of the State of New York or in the United States District Court for the Southern
District of New York, in either case sitting in the Borough of Manhattan in the City of New York, and hereby further irrevocably and unconditionally waive and agree not to plead or claim in any such court that any such action, suit or proceeding
brought in any such court has been brought in an inconvenient forum. 
 13.6.4. Service. Each Party further agrees that
service of any process, summons, notice or document by registered mail to its address set forth in Section 13.8 shall be effective service of process for any action, suit or proceeding brought against it under this Agreement in any such court.

 13.7 Dispute Resolution. 
 13.7.1. General. Except as provided in Section 10.4, if a dispute arises between the Parties in connection with or relating to this Agreement or any document or instrument delivered in
connection herewith (a “Dispute”), then either Party shall have the right to refer such Dispute to the chief executive officers of the Parties (or their designees) who shall

  
 45 

 
confer for attempted resolution of the Dispute by good faith negotiations during a period of thirty (30) Business Days. Any final decision mutually agreed to by such officers shall be
conclusive and binding on the Parties. In the event the chief executive officers are not able to resolve such Dispute within such thirty (30) Business Day period, then either of such officers may request, within five (5) Business Days
after the expiration of such period, that the Parties attempt non-binding mediation of any such Dispute for a period not to exceed thirty (30) Business Days. Upon any such request, the Parties shall participate in good faith in such non-binding
mediation. If the Dispute remains unresolved after such thirty (30)-Business Day mediation period, or if neither of such representatives so requests such non-binding mediation, then except as provided in Sections 13.7.2 and 13.18.3 and with respect
to any matter for which consent or approval is assigned to the Parties jointly, either Party may, by written notice to the other Party, initiate litigation for resolution of such Dispute. 

13.7.2. Interim Relief. Notwithstanding anything herein to the contrary, nothing in this Section 13.7 shall preclude either
Party from seeking interim or provisional relief, including a temporary restraining order, preliminary injunction or other interim equitable relief concerning a Dispute, if necessary to protect the interests of such Party. This Section 13.7.2
shall be specifically enforceable. 
 13.8 Notices. 

13.8.1. Notice Requirements. Any notice, request, demand, waiver, consent, approval or other communication permitted or required
under this Agreement shall be in writing, shall refer specifically to this Agreement and shall be deemed given only if delivered by hand or sent by facsimile transmission (with transmission confirmed) or by internationally recognized overnight
delivery service that maintains records of delivery, addressed to the Parties at their respective addresses specified in Section 13.8.2 or to such other address as the Party to whom notice is to be given may have provided to the other Party in
accordance with this Section 13.8. Such Notice shall be deemed to have been given as of the date delivered by hand or transmitted by facsimile (with transmission confirmed) or on the second Business Day (at the place of delivery) after deposit
with an internationally recognized overnight delivery service. Any notice delivered by facsimile shall be confirmed by a hard copy delivered as soon as practicable thereafter. This Section 13.8 is not intended to govern the day-to-day business
communications necessary between the Parties in performing their obligations under the terms of this Agreement. 

  
 46 

 13.8.2. Address for Notice.  

If to INS, to: 

Intellect Neurosciences Inc 
 45 West 36th Street 
 3rd Floor 

New York, NY 10018 
 Attention: Daniel G. Chain, Ph.D., Chairman & CEO 
 Fax: (212) 448 9600

 with a copy (which shall not constitute notice) to: 
 Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. 
 666 Third Avenue 

New York, New York 10017 
 Attention: Joel Papernik, Esquire 
 Facsimile: (212) 983-3115 

If to ViroPharma, to: 
 ViroPharma Incorporated 
 730 Stockton Drive 

Exton, Pennsylvania 19341 
 Attention: J. Peter Wolf, General Counsel 
 Facsimile: (610) 458-7380

 with a copy (which shall not constitute notice) to: 
 DLA Piper LLP (US) 
 The Marbury Building 

6225 Smith Avenue 
 Baltimore, MD 21209 
 Attention: Howard S. Schwartz, Esq. 

Facsimile: (410) 580-3251 
 13.9 Entire Agreement; Modifications. This Agreement, together with the Schedules and Exhibits attached hereto, sets forth and constitutes the entire agreement and understanding between the Parties
with respect to the subject matter hereof and all prior agreements, understandings, promises and representations, whether written or oral, with respect 

  
 47 

 
thereto are superseded hereby. Each Party confirms that it is not relying on any representations or warranties of the other Party except as specifically set forth herein. No amendment,
modification, release or discharge shall be binding upon the Parties unless in writing and duly executed by authorized representatives of both Parties. 
 13.10 English Language. This Agreement shall be written and executed in, and all other communications under or in connection with this Agreement shall be in, the English language. Any translation
into any other language shall not be an official version thereof, and in the event of any conflict in interpretation between the English version and such translation, the English version shall control. 

13.11 Equitable Relief. The Parties acknowledge and agree that the restrictions set forth in Section 2.5, Article 7 and
Article 9 are reasonable and necessary to protect the legitimate interests of the other Party and that such other Party would not have entered into this Agreement in the absence of such restrictions, and that any breach or threatened breach of any
provision of Section 2.5, Article 7 or Article 9 may result in irreparable injury to such other Party for which there will be no adequate remedy at law. In the event of a breach or threatened breach of any provision of Section 2.5, Article
7 and Article 9, the non-breaching Party shall be authorized and entitled to obtain from any court of competent jurisdiction injunctive relief, whether preliminary or permanent, specific performance and an equitable accounting of all earnings,
profits and other benefits arising from such breach, which rights shall be cumulative and in addition to any other rights or remedies to which such non-breaching Party may be entitled in law or equity. Both Parties agree to waive, to the maximum
extent permitted by Applicable Law, any requirement that the other (a) post a bond or other security as a condition for obtaining any such relief and (b) show irreparable harm, balancing of harms, consideration of the public interest or
inadequacy of monetary damages as a remedy. Nothing in this Section 13.11 is intended, or should be construed, to limit either Party’s right to equitable relief or any other remedy for a breach of any other provision of this Agreement.

 13.12 Waiver and Non-Exclusion of Remedies. Any term or condition of this Agreement may be waived at any time by the
Party that is entitled to the benefit thereof, but no such waiver shall be effective unless set forth in a written instrument duly executed by or on behalf of the Party waiving such term or condition. The waiver by either Party hereto of any right
hereunder or of the failure to perform or of a breach by the other Party shall not be deemed a waiver of any other right hereunder or of any other breach or failure by said other Party whether of a similar nature or otherwise. 

13.13 No Benefit to Third Parties. The representations, warranties, covenants and agreements set forth in this Agreement are for
the sole benefit of the Parties hereto and their successors and permitted assigns, and they shall not be construed as conferring any rights on any other Persons. 
 13.14 Further Assurance. Each Party shall duly execute and deliver, or cause to be duly executed and delivered, such further instruments and do and cause to be done such further acts and things,
including the filing of such assignments, agreements, documents and instruments, as may be necessary or as the other Party may reasonably request in connection with this Agreement or to carry out more effectively the provisions and purposes hereof,
or to better assure and confirm unto such other Party its rights and remedies under this Agreement. 

  
 48 

 13.15 Relationship of the Parties. It is expressly agreed that INS, on the one hand,
and ViroPharma, on the other hand, shall be independent contractors and that the relationship between the two Parties shall not constitute a partnership, joint venture or agency. Neither INS, on the one hand, nor ViroPharma, on the other hand, shall
have the authority to make any statements, representations or commitments of any kind, or to take any action, which shall be binding on the other, without the prior written consent of the other Party to do so, such consent not to be unreasonably
withheld or delayed. All persons employed by a Party shall be employees of such Party and not of the other Party and all costs and obligations incurred by reason of any such employment shall be for the account and expense of such Party. 

13.16 Performance by Affiliates. Each of INS and ViroPharma acknowledges that certain obligations under this Agreement may be
performed by Affiliates of INS and ViroPharma. Each of INS and ViroPharma guarantees performance of this Agreement by any of its Affiliates. 
 13.17 Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be deemed an original, but all of which together shall constitute one and the same instrument.
This Agreement may be executed by scanned and electronically or facsimile transmitted signatures and such signatures shall be deemed to bind each Party hereto as if they were original signatures. 

13.18 Payments; Audits. 
 13.18.1. Interest on Late Payments. If any payment due to a Party under this Agreement is not paid when due, then the owing Party shall pay interest thereon (before and after any judgment) at an
annual rate (but with interest accruing on a daily basis) equal to the lesser of (a) the prime rate as reported on the first Business Day of each month such payment is overdue in The Wall Street Journal, Eastern Edition, plus ***
percentage points, and (b) the maximum rate permitted by Applicable Law. Interest payable under this Section 13.18.1 shall run from the day following the date upon which payment of the relevant principal sum became due through the date of
payment thereof in full together with such interest. 
 13.18.2. Audit. Each Party shall have the right to have an
independent certified public accounting firm of internationally recognized standing, and reasonably acceptable to the other Party, provided with access by such other Party during normal business hours, and upon reasonable prior written notice, to
examine only those records of such other Party (and its Affiliates and sublicensees) as may be reasonably necessary to determine, with respect to any Calendar Year ending not more than three (3) years prior to the auditing Party’s request,
the correctness or completeness of any payment made under this Agreement. Such examinations may not (a) be conducted more than once in any *** period (unless a previous audit during such *** period revealed an underpayment with respect to such
period or the audited Party restates or revises such books and records for such period) or (b) be repeated for any Calendar Year. Results of such audit shall (i) be (A) limited to information relating to the Licensed Products,
(B) made available to both Parties in writing and (C) subject to Article 10 

  
 49 

 
and (ii) not reveal any specific information of the audited Party to the auditing Party other than (A) whether the audited Party is in compliance with its payment obligations under this
Agreement and (B) the amount of any additional payment owed to the auditing Party or excess payment reimbursable to the audited Party. Except as provided below, the cost of this examination shall be borne by the auditing Party, unless the audit
reveals a variance of more than five percent (5%) from the reported amounts, in which case the audited Party shall bear the cost of the audit. Unless disputed pursuant to Section 13.18.3, if such audit concludes that additional payments
were owed or that excess payments were made during such period, the audited Party shall pay the additional amounts, with interest from the date originally due as provided in Section 13.18.1, or the auditing Party shall reimburse such excess
payments, with interest from the date of original payment as provided in Section 13.18.1, within sixty (60) days after the date on which such auditor’s written report is delivered to the Parties. 

13.18.3. Audit Dispute. In the event of a Dispute of any audit under Section 13.18.2, INS and ViroPharma shall work in good
faith to resolve the disagreement. If the Parties are unable to reach a mutually acceptable resolution of any such Dispute within thirty (30) days, the Dispute shall be resolved in accordance with Section 13.7. 

13.18.4. Confidentiality. The receiving Party shall treat all information subject to review under this Section 13 in
accordance with the confidentiality provisions of Article 10. 
 13.19 References. Unless otherwise specified,
(a) references in this Agreement to any Article, Section, Schedule or Exhibit shall mean references to such Article, Section, Schedule or Exhibit of this Agreement, (b) references in any section to any clause are references to such clause
of such section and (c) references to any agreement, instrument or other document in this Agreement refer to such agreement, instrument or other document as originally executed or, if subsequently varied, replaced or supplemented from time to
time, as so varied, replaced or supplemented and in effect at the relevant time of reference thereto. 
 13.20 Construction.
Except where the context otherwise requires, wherever used, the singular shall include the plural, the plural the singular, the use of any gender shall be applicable to all genders and the word “or” is used in the inclusive sense
(and/or). The captions of this Agreement are for convenience of reference only and in no way define, describe, extend or limit the scope or intent of this Agreement or the intent of any provision contained in this Agreement. The term
“including” as used herein shall mean including, without limiting the generality of any description preceding such term. The language of this Agreement shall be deemed to be the language mutually chosen by the Parties and no rule of strict
construction shall be applied against either Party hereto. 
 [The remainder of this page has been intentionally left blank.]

  
 50 

 IN WITNESS WHEREOF, the Parties have executed this Agreement in duplicate originals by their proper
officers as of the date first written above. 
  

			
	INTELLECT NEUROSCIENCES, INC.
		
	By:	 	  

		
	Name:	 	  

		
	Title:	 	  

	
	INTELLECT USA, INC.
		
	By:	 	  

		
	Name:	 	  

		
	Title:	 	  

  

[SIGNATURE PAGE TO LICENSE AGREEMENT] 

			
	VIROPHARMA INCORPORATED
		
	By:	 	  

		
	Name:	 	  

		
	Title:	 	  

  

[SIGNATURE PAGE TO LICENSE AGREEMENT] 

 Schedule 1.47 

INS Patents 
  

																											
	COUNTRY	  	F&R Reference	  	TYPE	 	  	FILE	 	  	SERIALNO	 	  	ISSUE	 	  	PATENTNO	 	  	STATUS	 
								
	 ***
	  		  				  				  				  				  				  			
	 ***
	  		  				  				  				  				  				  			
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  
								
	COUNTRY	  	F&R Reference	  	TYPE	 	  	FILE	 	  	SERIALNO	 	  	ISSUE	 	  	PATENTNO	 	  	STATUS	 
								
	 ***
	  		  				  				  				  				  				  			
	 ***
	  		  				  				  				  				  				  			
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  

  
 Schedule 1.47
Page 1 

																											
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  	  	 	***	  
								
	 ***
	  	***	  	 	***	  	  	 	***	  	  	 	***	  	  				  				  	 	***	  

  
 Schedule 1.47
Page 2 

 Schedule 3.2.1 

Transferred Technology 
 INS shall, *** after the Effective Date, provide to ViroPharma, in such form and format as ViroPharma may reasonably request, all *** and *** from or relating to: 

*** 

  
 Schedule
3.2.1, Page-1 

 Schedule 3.2.2 

Transferred Materials 
 ***, including the following: 
 ***. 

***, including the following: 

*** 

  
 Schedule
3.2.2, Page-1 

 Schedule 10.3.5 

INS History and Academic License Chain of Title 
 In February 1997, Dr. Daniel Chain formed Mindset Limited (“Mindset BVI”), a British Virgin Islands corporation. 
 On August 10, 1998, Mindset BVI acquired the NYU License and SAMSF License. 
 In July 1999,
Dr. Chain founded Mindset Biopharmaceuticals USA, Inc., a Delaware corporation (“Mindset USA”), and Mindset Ltd., an Israeli corporation, as a wholly-owned subsidiary of Mindset USA (“Mindset
Israel”). 
 In December, 2001 MPM Capital, a private equity fund, and Clal Biotechnology Industries
(“CBI”) signed final agreements to invest a total of $15 million in Mindset USA. 
 In 2001, Dr. Chain founded
MindGenix Inc., a contract drug testing company, as a subsidiary of Mindset USA. MindGenix performed contract testing of drugs in an Alzheimer’s transgenic mouse model for third-party pharmaceutical companies and for Mindset USA/Mindset Israel.

 In September 2002, Mindset BVI entered into amendments to the NYU License and SAMSF License, which, among other things, assigned the licenses
to Mindset USA. 
 Intellect Neurosciences, Inc. was incorporated in Delaware on April 25, 2005 under the name Eidetic Biosciences, Inc.
and changed its name to Mindset Neurosciences, Inc. on April 28, 2005, to Lucid Neurosciences, Inc. on May 17, 2005 and to Intellect Neurosciences, Inc. on May 20, 2005. 
 Effective June 23, 2005, Intellect entered into an agreement (the “Asset Transfer Agreement”) with Mindset USA. to acquire from Mindset USA certain intellectual property
related assets, including the NYU License and the SAMSF License, patents, patent applications, trademarks, licenses, know-how inventions and certain inventories. The Asset Transfer Agreement included the purchase of all of Mindset USA’s debt to
disinterested creditors and a contribution toward the settlement of creditors of Mindset Israel including its former employees. 
 Effective
June 28, 2005, New York University and University of South Alabama Medical Science Foundation consented to the assignments of the NYU License and SAMSF License, respectively, from Mindset USA to Intellect Neurosciences, Inc. 

In October 2005, Dr. Chain resigned as CEO of Mindset USA and assumed the role of Chairman & CEO of Intellect Neurosciences, Inc.

 On January 25, 2007, GlobePan Resources, Inc. (“GlobePan”) entered into an agreement and plan of merger with
Intellect Neurosciences, Inc. and INS Acquisition, Inc. (“Acquisition Sub”) a wholly-owned Delaware subsidiary of GlobePan, pursuant to which Acquisition Sub merged with and into Intellect Neurosciences, Inc., Acquisition Sub
ceased to exist and Intellect Neurosciences, Inc. survived the merger and became the wholly-owned subsidiary of GlobePan. Intellect Neurosciences, Inc., the surviving entity in the merger, then changed its name to Intellect USA, Inc. and GlobePan
changed its name to Intellect Neurosciences, Inc. 

  
 Schedule
10.3.5, Page 1Exhibit 10.1

 Exhibit 10.1 
 LOCKHEED MARTIN CORPORATION 
 DEFERRED MANAGEMENT INCENTIVE

 COMPENSATION PLAN 
 (As Amended and Restated Effective October 25, 2011) 
 ARTICLE I

 PURPOSES OF THE PLAN 
 The purposes of the Lockheed Martin Corporation Deferred Management Incentive Compensation Plan (the “Deferral Plan”) are to provide certain key management employees of Lockheed Martin
Corporation and its subsidiaries (the “Company”) the opportunity to defer receipt of (i) Incentive Compensation awards under the Lockheed Martin Corporation Management Incentive Compensation Plan (the “MICP”); (ii) Long
Term Incentive Award payments under the Lockheed Martin Corporation 1995 Omnibus Performance Award Plan (the “Omnibus Plan”) and the Lockheed Martin Corporation Amended and Restated 2003 Incentive Performance Award Plan (the “IPA
Plan”); and (iii) certain benefits payable under the Lockheed Martin Corporation Post-Retirement Death Benefit Plan for Elected Officers (“Death Benefit Plan”). Providing this opportunity to defer income under the Deferral Plan
will encourage key employees to maintain a financial interest in the Company’s performance. Except as expressly provided hereinafter, the provisions of this Deferral Plan and the MICP, the Omnibus Plan, the IPA Plan, and the Death Benefit Plan
shall be construed and applied independently of each other. 
 The Deferral Plan applies solely to MICP awards, Long Term
Incentive Award payments under the Omnibus Plan and the IPA Plan, and certain payments under the Death Benefit Plan, and expressly does not apply to any special awards which may be made under any of the Company’s other incentive plans, except
and to the extent specifically provided under the terms of such other incentive plans and the relevant awards. 
 The Deferral
Plan was amended and restated, effective January 1, 2005, in order to comply with the requirements of Code section 409A. The 2005 amendment and restatement of the Deferral Plan applied only to the portion of a Participant’s Account Balance
that is earned or becomes vested on or after January 1, 2005 (and any earnings or losses attributable to that portion). The portion of a Participant’s Account Balance that was earned and vested prior to January 1, 2005 (and any
earnings or losses attributable to that portion) shall be governed by the terms of the Deferral Plan in effect on December 31, 2004, which is attached hereto as Appendix A. The Deferral Plan was subsequently amended and restated, effective
January 1, 2007, to permit eligible executives of the Company to defer payments that are available to them pursuant to the partial termination of the Death Benefit Plan. 
 The Deferral Plan was amended and restated, effective January 1, 2008 to modify the annual installment payment option to conform to other nonqualified plans maintained by the

 
Company. The Deferral Plan and Appendix A were further amended and restated, effective January 1, 2008, to provide for new investment options in which Participants may invest their Account
Balances, whether earned and vested before or after January 1, 2005. The addition of the new investment option in Appendix A is not intended to constitute a material modification within the meaning of Code section 409A. 

The Deferral Plan was amended and restated, effective June 26, 2008, to clarify certain provisions in accordance with the final
Treasury regulations issued under Code section 409A, and to make other administrative changes. The Deferral Plan was amended and restated, effective December 31, 2008, to clarify additional provisions in accordance with the final Treasury
regulations issued under Code section 409A and to make other administrative clarifications. The Deferral Plan was amended and restated, effective February 26, 2009, to prospectively eliminate an investment option and change the number of
available installment payments. 
 The Deferral Plan was amended and restated, effective December 31, 2010, to clarify
additional provisions in accordance with the final Treasury regulations issued under Code section 409A and to make other administrative clarifications. The Deferral Plan is hereby amended and restated to reflect changes to the administrative
requirements for Company Deferrals for certain Long Term Incentive Awards issued in 2011 and later years and to permit participants in the Sandia National Laboratories, Inc. Long Term Incentive Performance Award Plan to defer cash awards to the
Deferral Plan. 
 ARTICLE II 
 DEFINITIONS 
 Unless the context indicates otherwise, the following words
and phrases shall have the meanings hereinafter indicated: 
 1. ACCOUNT — The bookkeeping account maintained by the
Company for each Participant which is credited with the Participant’s Deferred Compensation and earnings (or losses) attributable to the investment options selected by the Participant, and which is debited to reflect distributions and
forfeitures; the portions of a Participant’s Account allocated to different investment options and the portions attributable to the deferral of Incentive Compensation awards, Long Term Incentive Award payments, and Death Benefit payments will
be accounted for separately. 
 2. ACCOUNT BALANCE — The total amount credited to a Participant’s Account at any point
in time, including the portions of the Account allocated to each investment option. 
 3. AWARD YEAR — As to Incentive
Compensation, the calendar year with respect to which an Eligible Employee is awarded Incentive Compensation; as to a Long Term Incentive Award payment and the related Company Deferral, the first calendar year in the Performance Period for which the
Long Term Incentive Award is effective with respect to an Eligible Employee. 

  
 2 

 4. BENEFICIARY — The person or persons (including a trust or trusts) validly designated
by a Participant, on the form provided by the Company, to receive distributions of the Participant’s Account Balance, if any, upon the Participant’s death. In the absence of a valid designation, or if the designated Beneficiary has
predeceased the Participant, the Participant’s Beneficiary shall be the personal representative of the Participant’s estate in the event of a Participant’s death. A Participant may amend his or her Beneficiary designation at any time
before the Participant’s death. 
 5. BOARD — The Board of Directors of Lockheed Martin Corporation. 

6. CODE — the Internal Revenue Code of 1986, as amended from time to time, including the regulations and guidance of general
applicability thereunder. 
 7. COMMITTEE — The committee described in Section 1 of Article VIII. 

8. COMMON STOCK — The $1.00 par value common stock of the Company. 

9. COMPANY — Lockheed Martin Corporation and its Subsidiaries. 

10. COMPANY DEFERRALS — The amount deferred by the Company, and not at the election of the Participant, for a two-year (one-year, if
applicable) period following the end of a Performance Period for a Long Term Incentive Award. 
 11. COMPANY STOCK INVESTMENT
OPTION — The investment option under which the amount credited to a Participant’s Account will be based on the market value and investment return of the Company’s Common Stock. 

12. DEATH BENEFIT — The amount payable to an Eligible Employee pursuant to Article X, Section 1 of the Death Benefit Plan.

 13. DEATH BENEFIT PLAN — The Lockheed Martin Corporation Post-Retirement Death Benefit Plan for Elected Officers.

 14. DEFERRAL AGREEMENT — The written agreement executed by an Eligible Employee on the form provided by the Company
under which the Eligible Employee elects to defer Incentive Compensation for an Award Year, a Long Term Incentive Award and any related Company Deferral for an Award Year, or a Death Benefit payable pursuant to the Death Benefit Plan. 

15. DEFERRAL PLAN — The Lockheed Martin Corporation Deferred Management Incentive Compensation Plan, adopted by the Board on
July 27, 1995, and as amended from time to time. 
 16. DEFERRED COMPENSATION — The amount of Incentive Compensation
credited to a Participant’s Account under the Deferral Plan, the amount of any Long Term Incentive Award payment credited to a Participant’s Account under the Deferral Plan 

  
 3 

 
(other than Company Deferrals), and the amount of the Death Benefit payment credited to a Participant’s Account under the Deferral Plan. 

17. ELIGIBLE EMPLOYEE — An employee of the Company who is a participant in the MICP, who receives a Long Term Incentive Award under
the Omnibus Plan, the IPA Plan, or the Sandia National Laboratories, Inc. Long Term Performance Award Plan, or who is eligible to receive a Death Benefit under the Death Benefit Plan, and who has satisfied such additional requirements for
participation in this Deferral Plan as the Committee may from time to time establish. In the exercise of its authority under this provision, the Committee shall limit participation in the Plan to employees whom the Committee believes to be a select
group of management or highly compensated employees within the meaning of Title I of the Employee Retirement Income Security Act of 1974, as amended. 
 18. EXCHANGE ACT — The Securities Exchange Act of 1934. 
 19. INCENTIVE
COMPENSATION — The MICP amount granted to an employee for an Award Year. 
 20 IPA PLAN — The Lockheed Martin
Corporation Amended and Restated 2003 Incentive Performance Award Plan. 
 21. INTEREST OPTION — The investment option
under which earnings will be credited to a Participant’s Account based on the interest rate applicable under Cost Accounting Standard 415, Deferred Compensation. 
 22. INVESTMENT FUND OPTION — The investment option under which earnings will be credited to a Participant’s Account based on the market value and investment return of the investment options
(including target date funds and core funds (and successor funds), and excluding the Company Stock Fund, ESOP Fund, and Self-Managed Account) that are available to participants pursuant to the terms of the Qualified Savings Plan, provided that the
Committee retains the discretion to add certain funds to, or to exclude certain funds from, the Investment Fund Option. 
 23.
LONG TERM INCENTIVE AWARD — A long term incentive performance award granted to an employee under the Omnibus Plan, the IPA Plan, or the Sandia National Laboratories, Inc. Long Term Incentive Award Plan. 

24. MICP — The Lockheed Martin Corporation Management Incentive Compensation Plan or the 2006 Lockheed Martin Corporation Management
Incentive Compensation Plan (for incentive compensation awarded after February 1, 2006). 
 25. OMNIBUS PLAN — The
Lockheed Martin Corporation 1995 Omnibus Performance Award Plan. 
 26. PARTICIPANT — An Eligible Employee for whom
Incentive Compensation, a Long Term Incentive Award payment, or a Death Benefit payment has been deferred for one or more years under this Deferral Plan; the term shall include a former employee whose Deferred Compensation has not been fully
distributed. 

  
 4 

 27. PAYMENT DATE — As to any Participant, the January 15 or July 15 on or
about on which payment to the Participant is to be made or to begin in accordance with Article V. 
 28. PERFORMANCE PERIOD
— The period set forth in a Long Term Incentive Award over which the Company’s performance is measured by reference to total stockholder return to determine whether any payment will be made under such Long Term Incentive Award. 

29. QUALIFIED SAVINGS PLAN — The Lockheed Martin Corporation Salaried Savings Plan or any successor plan. 

30. SECTION 16 PERSON — A Participant who is subject to the reporting and short-swing liability provisions of Section 16 of the
Securities Exchange Act of 1934 on the date a Deferral Agreement or other election form is delivered to the Company in accordance with the terms of this Deferral Plan. 
 31. SPECIFIED EMPLOYEE — A Participant who is reasonably determined to a be a “specified employee” within the meaning of Code section 409A(2)(B)(i) as of December 31 of a calendar year
and who shall be treated as such for the 12-month period beginning the next April 1 and for twelve calendar months thereafter. 
 32. SUBSIDIARY — As to any person, any corporation, association, partnership, joint venture or other business entity of which 50% or more of the voting stock or other equity interests (in the case of
entities other than corporation), is owned or controlled (directly or indirectly) by that entity, or by one or more of the Subsidiaries of that entity, or by a combination thereof. 

32A. TERMINATION OF EMPLOYMENT — A separation from service as such term is defined in Code section 409A and the regulations
thereunder. 
 33. TRADING DAY — A day upon which transactions with respect to Company Common Stock are reported in the
consolidated transaction reporting system. 
 ARTICLE III 

ELECTION OF DEFERRED AMOUNT 
 1. Timing of Deferral Elections. 
 (a) Incentive
Compensation. An Eligible Employee may elect to defer Incentive Compensation for an Award Year by executing and delivering to the Company a Deferral Agreement no later than June 30 of the Award Year. 

(b) Long Term Incentive Awards and Company Deferrals. An Eligible Employee may elect to defer the payment of a
Long Term Incentive Award and a Company Deferral for an Award Year by executing and delivering to the Company a Deferral Agreement as of a date specified by the Senior Vice 

  
 5 

 
President, Human Resources, which shall be no later than six months prior to the end of the Performance Period. 

(c) Irrevocability of Elections. No Eligible Employee shall have the right to modify or revoke a Deferral Agreement
after the applicable deadline described in Section 1(a), Section 1(b), or Section 1(d) of this Article III for delivering a Deferral Agreement to the Company, provided no Section 16 Person shall have the right to modify or revoke
a Deferral Agreement after such applicable deadline or, if earlier, after the date the agreement has been delivered to the Company. The Senior Vice President, Human Resources may establish policies and procedures to determine when a Deferral
Agreement or other election called for under this Plan has been delivered to the Company. Each Deferral Agreement that relates to an Award Year shall apply only to amounts deferred in that Award Year, and a separate Deferral Agreement must be
completed for each Award Year for which an Eligible Employee defers Incentive Compensation or a Long Term Incentive Award. A Deferral Agreement relating to a Death Benefit payment shall relate only to such Death Benefit payment. 

(d) Death Benefit. An Eligible Employee may elect to defer a Death Benefit payable under the Death Benefit Plan by
executing and delivering to the Company a Deferral Agreement no later than the date specified by the Senior Vice President, Human Resources in accordance with Code section 409A. 

2. Amount of Deferral Elections. An Eligible Employee’s deferral election may be stated as: 

(a) a dollar amount which is at least $5,000 and is an even multiple of $1,000; 

(b) the greater of $5,000 or a designated percentage of the Eligible Employee’s Incentive Compensation, Long Term
Incentive Award payment, or Death Benefit payment; 
 (c) the excess of the Eligible Employee’s Incentive
Compensation, Long Term Incentive Award payment, or Death Benefit payment over a dollar amount specified by the Eligible Employee; or 
 (d) all of the Eligible Employee’s Incentive Compensation, Long Term Incentive Award payment, or Death Benefit payment. 
 In the case of a deferral election under paragraph (c) of this Section 2, an Eligible Employee’s deferral election shall be effective only if the resulting excess amount is at least $5,000.

 3. Effect of Taxes on Deferred Compensation. The amount that would otherwise be deferred and credited to an Eligible
Employee’s Account will be reduced by the amount of any tax that the Company is required to withhold with respect to the Deferred Compensation. The reduction for taxes shall be made proportionately out of amounts otherwise

  
 6 

 
allocable to the Interest Option, the Company Stock Investment Option, or the Investment Fund Option. 
 4. Multiple Awards. In the case of an Eligible Employee who receives more than one Long Term Incentive Award with respect to the same Performance Period, the elections made by the Eligible Employee
under this Article III as well as under Articles V and VI for the first Long Term Incentive Award granted to the Eligible Employee with respect to a Performance Period shall be deemed to be the elections made by that Eligible Employee for any other
Long Term Incentive Awards granted to that Eligible Employee with respect to that same Performance Period. 
 5. Company
Deferrals. Pursuant to the terms of certain Long Term Incentive Awards issued under the Omnibus Plan or the IPA Plan, 50% of the amount payable at the end of the Performance Period will be automatically deferred until the second anniversary (or
first anniversary, if applicable) of the last day of the Performance Period with respect to a particular award. The Company may establish an account for Company Deferrals under the Company Stock Investment Option of this Deferral Plan. However, the
terms governing the Company Deferrals will be governed for the two year (one year, if applicable) period of deferral by the terms of the award agreement entered into under the Omnibus Plan or the IPA Plan with respect to the Long Term Incentive
Award and not by this Deferral Plan except to the extent the award agreement expressly refers to the terms of this Deferral Plan. Notwithstanding the foregoing, if the Participant elects to defer the Company Deferrals beyond the second (or first, if
applicable) anniversary of the end of the Performance Period, the deferrals will be treated as made under this Deferral Plan for the period following the second (or first, if applicable) anniversary of the end of the Performance Period. 

ARTICLE IV 

CREDITING OF ACCOUNTS 
 1. Crediting of Deferred Compensation. Incentive Compensation or a Long Term Incentive Award payment, that a Participant has elected to defer under this Deferral Plan shall be credited to the
Participant’s Account as of the Trading Day set by action of the Committee or, if the Committee does not act to set such a day, on the second Trading Day which follows the date of approval of the related Incentive Compensation or Long Term
Incentive Award payment (other than Company Deferrals). A Death Benefit payment that a Participant has elected to defer under this Deferral Plan shall be credited to the Participant’s Account as of the date on which the amount of the Death
Benefit payment was determined and paid to eligible employees absent any election to defer. If the Company establishes an account for Company Deferrals pursuant to Section 5 of Article III, the Company Deferrals shall be credited to such
account as of the last Trading Day in the Performance Period. Any Deferred Compensation credits under this Section 1 which are allocable to the Interest Option shall be credited at the dollar amount of such credits. Any Deferred Compensation
and Company Deferral credits under this Section 1 which are allocable to the Company Stock Investment Option shall be credited as if the dollar amount of credits had been invested in the Company’s Common Stock at the published closing
price of the Company’s Common Stock on the applicable Trading Day described in this Section 1. Any Deferred Compensation and Company Deferral credits under 

  
 7 

 
this Section 1 which are allocable to the Investment Fund Option shall be credited as if the dollar amount of credits had been invested in the applicable fund at the published closing price
of the applicable fund on the applicable Trading Day described in this Section 1. 
 2. Crediting of Earnings.

 (a) General Rules. 

(i) Earnings (or losses) shall be credited to a Participant’s Account based on the investment option or options to
which the Account has been allocated beginning with the applicable Trading Day described in this Article IV. 

(ii) Any amount distributed from a Participant’s Account in cash pursuant to Article V shall be credited with
earnings (or losses) through the Trading Day that is four (4) business days prior to the date on which a distribution is to be made. Any amount distributed from a Participant’s Account in stock pursuant to Article V shall be credited with
earnings (or losses) through the last Trading Day preceding the date on which a distribution is to be made. 

(iii) Company Deferrals shall be credited with earnings (or losses) through the last Trading Day in the period which ends
on the second anniversary (first anniversary, if applicable) of the end of the applicable Performance Period unless deferred further pursuant to a Deferral Agreement. 

(b) Interest Option. The portion of a Participant’s Account allocated or reallocated to the Interest Option
shall be credited with interest, valued daily, while so allocated or reallocated at a rate equivalent to the then published rate for computing the present value of future benefits at the time cost is assignable under Cost Accounting Standard 415,
Deferred Compensation, as determined by the Secretary of the Treasury on a semi-annual basis pursuant to Pub. L. 92-41, 85 Stat. 97. Effective with respect to amounts deferred on or after February 26, 2009, no Incentive Compensation may be
invested in the Interest Option. Amounts deferred prior to February 26, 2009 may remain invested in the Interest Option until such amounts are transferred to the Company Stock Investment Option or the Investment Fund Option on or after
July 1, 2009. No amounts may be credited or reallocated to the Interest Option on or after July 1, 2009. 
 (c) Company Stock Investment Option. 
 (i) The portion of a
Participant’s Account allocated to the Company Stock Investment Option shall be credited when so allocated on the applicable Trading Day described in this Article IV as if such amount had been invested in the Company’s Common Stock at the
published closing price of the Company’s Common Stock on such Trading Day. 
 (ii) The portion of the
Participant’s Account Balance allocated to the Company Stock Investment Option shall reflect any post-allocation appreciation or depreciation in the market value of the Company’s Common Stock based on the

  
 8 

 
published closing price of the stock on each Trading Day and shall reflect dividends paid and any other distributions made with respect to the Company’s Common Stock. 

(iii) Cash dividends shall be treated as if such dividends had been reinvested in the Company’s Common Stock at the
published closing price of the Company’s Common Stock on the Trading Day on which the cash dividend is paid or, if the dividend is paid on a day which is not a Trading Day, on the Trading Day which immediately precedes the day the dividend is
paid. 
 (d) Investment Fund Option. Earnings (or losses) shall be credited to a Participant’s
Account based on the investment option or options within the Investment Fund Option to which his or her Account has been allocated. The manner in which earnings (or losses) are credited under each of the investment options shall be determined in the
same manner as under the Qualified Savings Plan. The procedures for directing the allocation and reallocation among the investment options in the Investment Fund Option shall be the same as the procedures for making allocations under the Qualified
Savings Plan. 
 3. Election of Investment Options. A Participant’s initial investment elections for a particular
type of award for an Award Year or a Death Benefit shall be made in his or her Deferral Agreement for such Award Year or Death Benefit, and no Participant shall have the right to modify or revoke any such election after the time the Participant no
longer has the right to make or revoke a Deferral Agreement under Section 1 of Article II. A Participant’s allocations between investment options shall be subject to such minimum allocations as the Committee may establish. In the event a
Participant fails to specify an investment election in his or her Deferral Agreement, the amount subject to that Deferral Agreement shall be deemed allocated to the Interest Option for amounts credited before December 31, 2008 and to the
default option designated under the Qualified Savings Plan for amounts credited on or after December 31, 2008. 
 4.
Reallocation Among Investment Options. Effective June 16, 2008, a Participant may reallocate the portion of his Account Balance that is invested in the Interest Option and the Investment Fund Option to the Interest Option (through
June 30, 2009), the Company Stock Investment Option, and the various investment funds in the Investment Fund Option, subject to the trading restrictions that apply to the transfer and reallocation of investments under the terms of the Qualified
Savings Plan, applied as if such Qualified Savings Plan restrictions also pertain to the Interest Option; provided that a Participant may not at any time reallocate the portion of his Account Balance that has been invested at any time in the Company
Stock Investment Option. Notwithstanding the foregoing, any election by a Section 16 Person to reallocate any portion of his Account Balance to the Company Stock Investment Option shall only become effective if the election is made at least six
months following the most recent election with respect to any plan of the Corporation that involved the disposition of the Corporation’s equity securities pursuant to a “Discretionary Transaction” (as defined in Exchange Act Rule
16b-3). No amounts may be credited or reallocated to the Interest Option on or after July 1, 2009. 

  
 9 

 ARTICLE V 
 PAYMENT OF BENEFITS 
 1. General. 

(a) Account Balance and Elections. The Company’s liability to pay benefits to a Participant or Beneficiary
under this Deferral Plan shall be measured by and shall in no event exceed the Participant’s Account Balance. Except as otherwise provided in this Deferral Plan (including but not limited to Section 5 of Article III with respect to Company
Deferrals), a Participant’s Account Balance shall be paid to him in accordance with the Participant’s elections under this Article V. 
 (b) Cash and Stock Payments. All benefit payments shall be made in cash to the extent a Participant’s Account is allocated to the Interest Option or Investment Fund Option or is attributable
to Company Deferrals and shall be made in whole shares of the Company’s Common Stock to the extent that a Participant’s Account is allocated to the Company Stock Investment Option (other than with respect to Company Deferrals) and, except
as otherwise provided, shall reduce allocations to the Interest Option, Investment Fund Option, and the Company Stock Investment Option in the same proportions that the Participant’s Account Balance is allocated between those investment options
at the end of the month preceding the date of distribution. Notwithstanding the foregoing, no amount of Deferred Compensation attributable to the Company Stock Investment Option shall be distributed to a Section 16 Person under this Deferral
Plan unless such amount was allocated to the Company Stock Investment Option in accordance with Section 1 of Article IV at least six months prior to the date of distribution. At the Company’s discretion a distribution of Common Stock may
be made directly to a Participant or to a brokerage account opened in the name of the Participant. When an Account is distributed in a lump sum or, if an Account is distributed in installments, cash shall be distributed (or withheld for payment of
applicable taxes) at that time in lieu of any fractional share of Common Stock. The cash distribution in lieu of fractional shares shall be based on the published closing price of the Company’s Common Stock on the last Trading Day preceding the
date the distribution is scheduled to be made. 
 2. Election for Commencement of Payment. At the time a Participant
completes a Deferral Agreement, he or she shall elect from among the following options governing the date on which the payment of benefits shall commence: 
 (a) Payment to begin on the Payment Date next following the date of the Participant’s Termination of Employment with the Company for any reason. 

  
 10 

 (b) Payment to begin on the first Payment Date of the year next following
the year in which the Participant has a Termination of Employment with the Company for any reason. 
 (c) Payment
to begin on the first Payment Date of the year next following the date on which the Participant has both had a Termination of Employment with the Company for any reason and attained the age designated by the Participant in the Deferral Agreement.

 Notwithstanding a Participant’s election or any other provision of the Deferral Plan, the following specific rules apply to Participants
who are Section 16 Persons or Specified Employees. Subject to the rules regarding distributions to a Specified Employee, any payment of benefits in the form of shares of Common Stock that would result in a nonexempt short-swing transaction
under Section 16(b) of the Exchange Act shall be delayed until the earliest date upon which the Company reasonably anticipates that the distribution either would not result in a nonexempt short-swing transaction or would otherwise not result in
liability under Section 16(b) of the Exchange Act. Any distributions to a Specified Employee (including a Section 16 Person) on account of a termination of employment shall commence or be made on the Payment Date determined pursuant to the
Specified Employee’s election (or as otherwise provided under this Deferral Plan), except that if such Payment Date would be within six (6) months of the date of the Specified Employee’s Termination of Employment from the Company,
distributions shall commence or be made on the next date that is at least six (6) months following such termination of employment, regardless of whether such date is a Payment Date. 

3. Election for Form of Payment. At the time a Participant completes a Deferral Agreement, he or she shall elect the form of
payment of his or her Deferred Compensation for the specified Award Year or Death Benefit, as applicable, from among the following options: 
 (a) A lump sum. 
 (b) Annual installment payments for a period of
years designated by the Participant not to exceed: 
 (i) Fifteen (15) annual installments for
distributions commencing prior to January 1, 2008: 
 (ii) Twenty (20) annual installments for
distributions commencing on or after January 1, 2008 and prior to January 1, 2010: 
 (iii)
Twenty-Five (25) annual installments for distributions commencing on or after January 1, 2010; 
 Such election shall
be irrevocable except as provided in Section 4 of this Article V. The amount of each annual payment shall be determined by dividing the Participant’s Account Balance at the end of the month prior to such payment by

  
 11 

 
the number of installment payments then remaining in the designated installment period. 
 Notwithstanding the foregoing, if the Account Balance of a Participant who is entitled to begin payment equals $10,000 or less, the Participant’s Account Balance shall be paid in a single lump sum
payment in full discharge of all liabilities with respect to such benefits. 
 4. Prospective Change of Payment
Elections. 
 (a) If a Participant has different payment options in effect with respect to his or her Account
Balance, the Company shall maintain sub-accounts for the Participant to determine the amounts subject to each payment election. 
 (b) In the event a Participant does not make a valid election with respect to the commencement of payment and form of benefit for an Award Year or for a Death Benefit, the Participant will be deemed to
have elected that payment of benefits with respect to that Award Year or Death Benefit be made in a lump sum on or about the Payment Date next following the date of the Participant’s termination of employment. 

(c) A Participant’s election with respect to an Award Year or Death Benefit (including a “deemed election”
in accordance with the preceding paragraph) shall remain in effect unless and until such election is modified by a subsequent election in accordance with (d) below. 

(d) Notwithstanding anything to the contrary in this Article V, a Participant may make a new election with respect to the
commencement of payment and form of payment with respect to any sub-account maintained for Award Years or a Death Benefit or with respect to his or her entire Account Balance. A new election under this section shall be made by executing and
delivering to the Company an election in such form as prescribed by the Company. To constitute a valid election by a Participant making a prospective change to a previous election, (i) the prospective election must be executed and delivered to
the Company at least twelve (12) months before the date the first payment would be due under the Participant’s previous election, and (ii) the first payment must be delayed by at least sixty (60) months from the date the first
payment would be due under the Participant’s previous election, and (iii) such change in election shall not be given effect until twelve 12 months from the date that the change in election is delivered to the Company. In the event an
election fails to satisfy the provisions set forth in this paragraph, such election shall be void and, if such an election is void, payment shall be made in accordance with the most recent election which was valid. 

(e) Notwithstanding the above, for periods prior to January 1, 2009, (or such later date as may be provided by the
Internal Revenue Service in guidance of general applicability), the Senior Vice President, Human Resources 

  
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may provide alternative rules for elections with respect to the commencement of payment and form of payment that conform to the rules provided in Notice 2005-1, and subsequent Internal Revenue
Service guidance providing transition relief under Code section 409A. 
 (f) A Participant may not make or modify
an election with respect to commencement of payment or form of payment after the date a Participant terminates employment. 

5. Distribution upon Early Termination. Notwithstanding a Participant’s payment elections under this Article V, subject to
the requirements of Code section 409A, if the Participant terminates employment with the Company, other than by reason of death or disability (as defined in Section 8(b) of this Article V), and before the Participant has attained age 55, except
as provided in Section 5 of Article III with respect to Company Deferrals, the Participant’s Account Balance shall be distributed to him or her in a lump sum on or about the Payment Date next following the date of the Participant’s
Termination of Employment with the Company; provided, however, that if a distribution in accordance with the provisions of this Section 6 from the portion of the Participant’s Account allocated to the Company Stock Investment Option would
otherwise result in a nonexempt short-swing transaction under Section 16(b) of the Exchange Act, the date of distribution with respect to such portion to such Section 16 Person shall be delayed until the earliest date upon which the
Company reasonably anticipates that the distribution either would not result in a nonexempt short-swing transaction or would otherwise not result in liability under Section 16(b) of the Exchange Act. Distributions under this Section 5 are
subject to any delay in distribution required for Specified Employees as provided in Section 2 of this Article V. 
 6.
Acceleration Upon Conflict of Interest. Notwithstanding a Participant’s payment elections under this Article V, if following a Participant’s termination of employment with the Company, the Participant takes a position (or accepts a
position) with a governmental entity, agency, or instrumentality and that employer has determined that the Participant’s continued participation in the Plan may constitute a conflict of interest precluding the Participant from continuing in his
position (or from accepting an offered position) with that employer or subjecting the Participant to penalty, sanction, or otherwise limiting the Participant’s responsibilities for that employer, except as provided in Section 5 of Article
III with respect to Company Deferrals, then, to the extent reasonably necessary, the Participant’s Account Balance shall be distributed to him or her in a lump sum as soon as practical (but no later than 90 days) following the later of
(i) the date on which the Participant commences employment with the government employer; or (ii) the date on which it is determined or indicated that the conflict of interest may exist; provided, however, that if a distribution in
accordance with the provisions of this Section 6 from the portion of the Participant’s Account allocated to the Company Stock Investment Option would otherwise result in a nonexempt short-swing transaction under Section 16(b) of the
Exchange Act, the date of distribution with respect to such portion to such Section 16 Person shall be delayed until the earliest date upon which the Company reasonably anticipates that the distribution either would not result in a nonexempt
short-swing transaction or would otherwise not result in liability under Section 16(b) of the Exchange Act. This Section 6 of Article V shall apply, however, only to the extent that the accelerated payment upon a conflict of interest
determination conforms to Code section 409A. 

  
 13 

 7. Benefits Payable Upon Death. Upon the death of a Participant before a complete
distribution of his or her Account Balance, the Account Balance will be paid to the Participant’s Beneficiary in accordance with the payment elections applicable to the Participant. If a Participant dies while actively employed or otherwise
before the payment of benefits has commenced, payments to the Beneficiary shall commence on the date payments to the Participant would have commenced, taking account of the Participant’s Termination of Employment (by death or before) and, if
applicable, by postponing commencement until after the date the Participant would have attained the commencement age specified by the Participant. Whether the Participant dies before or after the commencement of distributions, payments to the
Beneficiary shall be made for the period or remaining period elected by the Participant. 
 8. Early Distributions in Special
Circumstances. Notwithstanding a Participant’s payment elections under this Article V, a Participant or Beneficiary may request an earlier distribution in the following limited circumstances (except as provided in Section 5 of Article
III with respect to Company Deferrals): 
 (a) Hardship Distributions. A Participant may apply for a
hardship distribution pursuant to this Section 8(a) on such form and in such manner as the Committee shall prescribe and, subject to the last sentence of this Section 8(a) with respect to Section 16 Persons, the Committee shall have
the power and discretion at any time to approve a payment to a Participant if the Committee determines that the Participant is suffering from an unforeseeable severe financial emergency (within the meaning of Code section 409A(A)(2)(A)(vi) and
409A(A)(2)((B)(ii)) caused by circumstances beyond the Participant’s control which would cause a hardship to the Participant unless such payment were made. Any such hardship payment will be in a lump sum and will not exceed the lesser of
(i) the amount necessary to satisfy the financial emergency (taking account of the income tax liability associated with the distribution), or (ii) the Participant’s Account Balance; provided, however, that if a distribution in
accordance with the provisions of this Section 8(a) from the portion of the Participant’s Account allocated to the Company Stock Investment Option would otherwise result in a nonexempt short-swing transaction under Section 16(b) of
the Exchange Act, the date of distribution with respect to such portion to such Section 16 Person shall be delayed until the earliest date upon which the Company reasonably anticipates that the distribution either would not result in a
nonexempt short-swing transaction or would otherwise not result in liability under Section 16(b) of the Exchange Act. The Committee’s determination under this Section 8(a) shall conform to the requirements of Code section
409A(a)(2)(B)(iv). 
 (b) Disability. If the Committee determines that a Participant has become
permanently disabled within the meaning of Section 409A(a)(2)(C) of the Code before the Participant’s entire Account Balance has been distributed, the Participant’s remaining Account Balance will be distributed within 90 days in a
lump sum payment; provided, however, that if a distribution in accordance with the provisions of this Section 8(b) from the portion of the Participant’s Account allocated to the Company Stock Investment Option would otherwise result in a
nonexempt short-swing transaction under Section 16(b) of the Exchange Act, the 

  
 14 

 
date of distribution with respect to such portion to any Section 16 Person shall be delayed until the earliest date upon which the Company reasonably anticipates that the distribution either
would not result in a nonexempt short-swing transaction or would otherwise not result in liability under Section 16(b) of the Exchange Act. 
 9. Acceleration upon Change in Control. 
 (a)
Notwithstanding any other provision of the Deferral Plan, except as provided in Section 5 of Article III with respect to Company Deferrals, the Account Balance of each Participant shall be distributed in a single lump sum within fifteen
(15) calendar days following a “Change in Control.” 
 (b) For purposes of this Deferral Plan, a
Change in Control shall include and be deemed to occur upon the following events: 
 (i) A tender offer or
exchange offer is consummated for the ownership of securities of the Company representing 25% or more of the combined voting power of the Company’s then outstanding voting securities entitled to vote in the election of directors of the Company.

 (ii) The Company is merged, combined, consolidated, recapitalized or otherwise reorganized with one or more
other entities that are not the Company’s Subsidiaries and, as a result of the merger, combination, consolidation, recapitalization or other reorganization, less than 75% of the outstanding voting securities of the surviving or resulting
corporation shall immediately after the event be owned in the aggregate by the stockholders of the Company (directly or indirectly), determined on the basis of record ownership as of the date of determination of holders entitled to vote on the
action (or in the absence of a vote, the day immediately prior to the event). 
 (iii) Any person (as this term
is used in Sections 3(a)(9) and 13(d)(3) of the Exchange Act, but excluding any person described in and satisfying the conditions of Rule 13d-1 (b)(1) thereunder), becomes the beneficial owner (as defined in Rule 13d-3 under the Exchange Act),
directly or indirectly, of securities of the Company representing 25% or more of the combined voting power of the Company’s then outstanding securities entitled to vote in the election of directors of the Company. 

(iv) At any time within any period of two years after a tender offer, merger, combination, consolidation,
recapitalization, or other reorganization or a contested election, or any combination of these events, the “Incumbent Directors” shall cease to constitute at least a majority of the authorized number of members of the Board. For purposes
hereof, “Incumbent Directors” shall mean the persons who were members of the Board immediately before the first of these events and the persons who 

  
 15 

 
were elected or nominated as their successors or pursuant to increases in the size of the Board by a vote of at least three-fourths of the Board members who were then Board members (or successors
or additional members so elected or nominated). 
 (v) The stockholders of the Company approve a plan of
liquidation and dissolution or the sale or transfer of substantially all of the Company’s business and/or assets as an entirety to an entity that is not a Company Subsidiary. 

Notwithstanding the foregoing, no distribution shall be made solely on account of a Change in Control and prior to the benefit
commencement date specified in Section 2 of Article V unless the Change in Control is an event qualifying for a distribution of deferred compensation under both the definition of Change in Control in this Plan and in
Section 409A(a)(2)(A)(v) of the Code. 
 (c) Notwithstanding the provisions of Section 9(a), if a
distribution in accordance with the provisions of Section 9(a) would result in a nonexempt short-swing transaction under Section 16(b) of the Exchange Act with respect to any Section 16 Person, then the date of distribution to such
Section 16 Person shall be delayed until the earliest date upon which the Company reasonably anticipates that the distribution either would not result in a nonexempt short-swing transaction or would otherwise not result in liability under
Section 16(b) of the Exchange Act. 
 (d) This Section 9 shall apply only to a Change in Control of
Lockheed Martin Corporation and shall not cause immediate payout of Deferred Compensation in any transaction involving the Company’s sale, liquidation, merger, or other disposition of any subsidiary. 

(e) The Committee may cancel or modify this Section 9 at any time prior to a Change in Control. In the event of a
Change in Control, this Section 9 shall remain in force and effect, and shall not be subject to cancellation or modification for a period of five years, and any defined term used in Section 9 shall not, for purposes of Section 9, be
subject to cancellation or modification during the five-year period. 
 10. Deductibility of Payments. Subject to the
provisions of Code section 409A, in the event that the Company reasonably anticipates that the payment of benefits in accordance with the Participant’s election under Section 3 of this Article VI would prevent the Company from claiming an
income tax deduction with respect to any portion of the benefits paid under Code section 162(m), the Committee shall have the right to delay the timing of distributions from the Participant’s Account as necessary to maximize the Company’s
tax deductions. In the exercise of its discretion to adopt a delayed distribution schedule, the Committee shall undertake to have distributions made at such times and in such amounts as the Company reasonably anticipates, or should reasonably
anticipate, that if the payment is made during such year, the deduction will not be barred by Code section 162(m) or upon a Termination of Employment in accordance with Treasury Regulation section 1.409A-2(b)(7)(i), consistent with the objective of
maximum 

  
 16 

 
deductibility for the Company. The Committee shall have no authority to reduce a Participant’s Account Balance or to pay aggregate benefits less than the Participant’s Account Balance
in the event that all or a portion thereof would not be deductible by the Company. All scheduled payments under this Plan and any other plan required to be aggregated with this Plan must be delayed in order for such payment to be delayed pursuant to
this Section 8. 
 11. Change of Law. Notwithstanding anything herein to the contrary, if the Committee determines
in good faith, based on consultation with counsel and in accordance with the requirements of Code section 409A, that the Federal income tax treatment or legal status of the Plan has or may be adversely affected by a change in the Code, Title I of
the Employee Retirement Income Security Act of 1974, or other applicable law or by an administrative or judicial construction thereof, the Committee may direct that the Accounts of affected Participants or of all Participants be distributed as soon
as practicable after such determination is made, to the extent deemed necessary or advisable by the Committee to cure or mitigate the consequences, or possible consequences of, such change in law or interpretation thereof. 

12. Tax Withholding. To the extent required by law, the Company shall withhold from benefit payments hereunder, or with respect to
any Incentive Compensation, Long Term Incentive Award, or Death Benefit payment deferred hereunder or credit contributed by the Company under Article IV, any Federal, state, or local income or payroll taxes required to be withheld and shall furnish
the recipient and the applicable government agency or agencies with such reports, statements, or information as may be legally required. 
 ARTICLE VI 
 EXTENT OF PARTICIPANTS’ RIGHTS 

1. Unfunded Status of Plan. This Deferral Plan constitutes a mere contractual promise by the Company to make payments in the
future, and each Participant’s rights shall be those of a general, unsecured creditor of the Company. No Participant shall have any beneficial interest in any specific assets that the Company may hold or set aside in connection with this
Deferral Plan. Notwithstanding the foregoing, to assist the Company in meeting its obligations under this Deferral Plan, the Company may set aside assets in a trust described in Revenue Procedure 92-64, 1992-2 C.B. 422, and the Company may direct
that its obligations under this Deferral Plan be satisfied by payments out of such trust. The assets of any such trust will remain subject to the claims of the general creditors of the Company. It is the Company’s intention that the Deferral
Plan be unfunded for Federal income tax purposes and for purposes of Title I of the Employee Retirement Income Security Act of 1974. 
 2. Nonalienability of Benefits. A Participant’s rights under this Plan shall not be assignable or transferable and any purported transfer, assignment, pledge or other encumbrance or attachment
of any payments or benefits under this Plan, or any interest therein shall not be permitted or recognized, other than the designation of, or passage of payment rights to, a Beneficiary. Notwithstanding, any portion of a Participant’s benefit
under this Plan may be paid to a spouse, former spouse, or child pursuant to the terms of a domestic relations order (which shall be interpreted and administered in accordance with Code sections

  
 17 

 
414(p)(1)(B) and 409A), provided that the form of payment designated in such order is a lump sum payment described in Section 3(a) of Article V of this Deferral Plan. 

ARTICLE VII 
 AMENDMENT OR TERMINATION 
 1. Amendment. The Board or its
authorized delegate may amend, modify, suspend or discontinue this Deferral Plan at any time subject to any shareholder approval that may be required under applicable law, provided, however, that no such amendment shall have the effect of reducing a
Participant’s Account Balance or postponing the time when a Participant is entitled to receive a distribution of his Account Balance. Further, no amendment may alter the formula for crediting interest to Participants’ Accounts with respect
to amounts for which deferral elections have previously been made, unless the amended formula is not less favorable to Participants than that previously in effect, or unless each affected Participant consents to such change. 

2. Termination. The Board reserves the right to terminate this Plan at any time and to pay all Participants their Account
Balances in any form and at such times that the Board reasonably determines in its discretion is appropriate and conforms to the requirements of Code section 409A; provided, however, that if a distribution in accordance with the provisions of this
Section 2 would otherwise result in a nonexempt short-swing transaction under Section 16(b) of the Exchange Act, the date of distribution with respect to any Section 16 Person shall be delayed until the earliest date upon which the
distribution either would not result in a nonexempt short-swing transaction or would otherwise not result in liability under Section 16(b) of the Exchange Act. 
 3. Transfer of Liability. The Board reserves the right to transfer to another entity all of the obligations of Company with respect to a Participant under this Plan if such entity agrees pursuant
to a binding written agreement to assume all of the obligations of the Company under this Plan with respect to such Participant. 

ARTICLE VIII 
 ADMINISTRATION 
 1. The Committee. This Deferral Plan shall be
administered by the Management Development and Compensation Committee of the Board or such other committee of the Board as may be designated by the Board and constituted so as to permit this Deferral Plan to comply with the disinterested
administration requirements of Rule 16b-3 of the Exchange Act. The members of the Committee shall be designated by the Board. A majority of the members of the Committee (but not fewer than two) shall constitute a quorum. The vote of a majority of a
quorum or the unanimous written consent of the Committee shall constitute action by the Committee. The Committee and the Claims Administrator (identified in Section 6 below) shall have full authority to interpret the Plan, and interpretations
of the Plan by the Committee or the Claims Administrator shall be final and binding on all parties. Notwithstanding anything contained in the Deferral Plan or in any document issued under the 

  
 18 

 
Deferral Plan, it is intended that the Deferral Plan will at all times conform to the requirements of Code section 409A and any regulations or other guidance issued thereunder, and that the
provisions of the Deferral Plan will be interpreted to meet such requirements. If any provision of the Deferral Plan is determined not to conform to such requirements, the Deferral Plan shall be interpreted to omit such offending provision. 

 2. Delegation and Reliance. The Committee has delegated to the officers or employees of the Company the authority to
execute and deliver those instruments and documents, to do all acts and things, and to take all other steps deemed necessary, advisable or convenient for the effective administration of this Deferral Plan in accordance with its terms and purpose,
except that the Committee has not delegated (and may not delegate) any authority the delegation of which would cause this Deferral Plan to fail to satisfy the applicable requirements of Rule 16b-3. In making any determination or in taking or not
taking any action under this Deferral Plan, the Committee or its delegate may obtain and rely upon the advice of experts, including professional advisors to the Company. No member of the Committee or officer of the Company who is a Participant
hereunder may participate in any decision specifically relating to his or her individual rights or benefits under the Deferral Plan. 
 3. Exculpation and Indemnity. Neither the Company nor any member of the Board or of the Committee, nor any other person participating in any determination of any question under this Deferral Plan,
or in the interpretation, administration or application thereof, shall have any liability to any party for any action taken or not taken in good faith under this Deferral Plan or for the failure of the Deferral Plan or any Participant’s rights
under the Deferral Plan to achieve intended tax consequences, to qualify for exemption or relief under Section 16 of the Exchange Act and the rules thereunder, or to comply with any other law, compliance with which is not required on the part
of the Company. 
 4. Facility of Payment. If a minor, person declared incompetent, or person incapable of handling the
disposition of his or her property is entitled to receive a benefit, make an application, or make an election hereunder, the Committee or the Claims Administrator may direct that such benefits be paid to, or such application or election be made by,
the guardian, legal representative, or person having the care and custody of such minor, incompetent, or incapable person. Any payment made, application allowed, or election implemented in accordance with this Section shall completely discharge the
Company and the Committee (or the Claims Administrator) from all liability with respect thereto. 
 5. Proof of Claims.
The Committee or the Claims Administrator may require proof of the death, disability, incompetency, minority, or incapacity of any Participant or Beneficiary and of the right of a person to receive any benefit or make any application or election.

 6. Claim Procedures. The procedures when a claim under this Deferral Plan is wholly or partially denied by the Claims
Administrator are as follows: 
 (a) The Claims Administrator shall, within 90 days after receipt of a claim,
furnish to claimant a written notice setting forth, in a manner calculated to be understood by claimant: (1) the specific reason or reasons for the denial; (2) 

  
 19 

 
specific reference to pertinent Deferral Plan provisions on which the denial is based; (3) a description of any additional materials or information necessary for the claimant to perfect the
claim and an explanation of why such material or information is necessary; (4) an explanation of the steps to be taken if the claimant wishes to have the denial reviewed; and (5) a statement of the claimant’s right to bring a civil
action under section 502(a) of ERISA following an adverse determination on review. The 90-day period may be extended for not more than an additional 90 days if special circumstances make such an extension necessary. The Claims Administrator shall
give the claimant, before the end of the initial 90-day period, a written notice of such extension, stating such special circumstances and the date by which the Claims Administrator expects to render a decision. 

(b) By a written application filed with the Claims Administrator within 60 days after receipt by claimant of the written
notice described in paragraph (a), the claimant or his duly authorized representative may request review of the denial of his claim. 
 (c) In connection with such review, the claimant or his duly authorized representative may submit issues, comments, documents, records and other information relating to the claim for benefits to the
Claims Administrator. In addition, the claimant will be provided, upon request and free of charge, reasonable access to and copies of all documents, records, or other information “relevant” to claimant’s claim for benefits. A
document, record, or other information is “relevant” if it: (1) was relied upon in making the benefit determination; (2) was submitted, considered or generated in the course of making the benefit determination, without regard to
whether such document, record or information was relied upon in making the benefit determination; or (3) demonstrates compliance with administrative processes and safeguards required under Federal law. 

(d) The Deferral Plan will provide an impartial review that takes into account all comments, records and other
information submitted by the claimant relating to the claim, without regard to whether such information was submitted or considered in the initial benefit determination. The Claims Administrator shall make a decision and furnish such decision in
writing to the claimant within 60 days after receipt by the Claims Administrator of the request for review. This period may be extended to not more than 120 days after such receipt if special circumstances make such an extension necessary. The
claimant will be notified in writing prior to the expiration of the original 60-day period if such an extension is required, and such notice will include the reason for the extension and the date by which it is expected that a decision will be
reached. The decision on review shall be in writing, set forth in a manner calculated to be understood by the claimant and shall include: (1) the specific reasons for the decision; (2) specific reference to the pertinent Deferral Plan
provisions on which the decision is based; (3) a statement that the claimant is entitled to receive, upon request and free of charge, reasonable access to and copies of all documents, records, and other information “relevant” to the
claimant’s claim for benefits; (4) a description of any additional material or information necessary for the claimant to perfect the claim and an explanation of 

  
 20 

 
why such material or information is necessary; (5) a statement describing any voluntary appeal procedures and the claimant’s right to obtain information about such procedures, if any;
and (6) a statement of the claimant’s right to bring a civil action under section 502(a) of ERISA following an adverse benefit determination on review. If in the event that the reviewing committee must make a determination of disability in
order to decide a claim, the reviewing committee shall follow the special claims procedures for disability benefits described in Department of Labor Regulation section 2560.503-1(d). The reviewing committee shall render a decision within a
reasonable time (not to exceed 90 days) after the claimant’s request for review, rather than within 120 days as set forth in the above paragraph. 
 (e) The Claims Administrator shall be the Lockheed Martin Corporation Savings Plan Administrative Committee. Notwithstanding the foregoing, with respect to claims and appeals brought by elected officers
of the Company, the Claims Administrator shall be the Committee. 
 ARTICLE IX 

GENERAL AND MISCELLANEOUS PROVISIONS 
 1. No Guarantee of Employment or Award. Neither this Deferral Plan, a Company Deferral nor a Participant’s Deferral Agreement, either singly or collectively, shall in any way obligate the
Company to continue the employment of a Participant with the Company, nor does either this Deferral Plan, a Company Deferral or a Deferral Agreement limit the right of the Company at any time and for any reason to terminate the Participant’s
employment. In no event shall this Deferral Plan, a Company Deferral or a Deferral Agreement, either singly or collectively, by their terms or implications constitute an employment contract of any nature whatsoever between the Company and a
Participant. In no event shall this Deferral Plan, a Company Deferral or a Deferral Agreement, either singly or collectively, by their terms or implications in any way obligate the Company to award Incentive Compensation, grant any award under the
Omnibus Plan or IPA Plan, pay any Death Benefit, or make any Long Term Incentive Award payment to any Eligible Employee for any Award Year, whether or not the Eligible Employee is a Participant in the Deferral Plan for that Award Year, nor in any
other way limit the right of the Company to change an Eligible Employee’s compensation or other benefits. 
 2.
Notice. Any written notice to the Company referred to herein shall be made by mailing or delivering such notice to the Company at 6801 Rockledge Drive, Bethesda, Maryland 20817, to the attention of the Senior Vice President, Human Resources.
Any written notice to a Participant shall be made by delivery to the Participant in person, through electronic transmission, or by mailing such notice to the Participant at his or her last-known place of residence or business address. 

3. Performance of Acts. In the event it should become impossible for the Company or the Committee to perform any act required by
this Deferral Plan, the Company or the Committee may perform such other act as it in good faith determines will most nearly carry out the intent and the purpose of this Deferral Plan. 

  
 21 

 4. Employee Consent. By electing to become a Participant hereunder, each Eligible
Employee shall be deemed conclusively to have accepted and consented to all of the terms of this Deferral Plan. 
 5. Terms
Binding. The provisions of this Deferral Plan and the Deferral Agreements hereunder shall be binding upon and inure to the benefit of the Company, its successors, and its assigns, and to the Participants and their heirs, executors,
administrators, and legal representatives. 
 6. Copy of Plan. A copy of this Deferral Plan shall be available for
inspection by Participants or other persons entitled to benefits under the Deferral Plan at reasonable times at the offices of the Company. 
 7. State Law. The validity of this Deferral Plan or any of its provisions shall be construed, administered, and governed in all respects under and by the laws of the State of Maryland, except as to
matters of Federal law. If any provisions of this instrument shall be held by a court of competent jurisdiction to be invalid or unenforceable, the remaining provisions hereof shall continue to be fully effective. 

8. Regulatory Requirements. This Deferral Plan and its operation, including but not limited to, the mechanics of deferral
elections, the reallocation of all or a portion of a Participant’s Account Balance, the issuance of securities, if any, or the payment of cash hereunder is subject to compliance with all applicable Federal and state laws, rules and regulations
(including but not limited to state and Federal insider trading, registration, reporting and other securities laws) and such other approvals by any listing, regulatory or governmental authority as may, in the opinion of counsel for the Company, be
necessary or advisable in connection therewith. 
 9. Section 16 of Exchange Act. It is the intent of the Company
that this Deferral Plan satisfy and be interpreted in a manner, that, in the case of Participants who are or may be Section 16 Persons, satisfies any applicable requirements of Rule 16b-3 of the Exchange Act or other exemptive rules under
Section 16 of the Exchange Act and will not subject Section 16 Persons to short-swing profit liability thereunder. If any provision of this Deferral Plan would otherwise frustrate or conflict with the intent expressed in this
Section 9, that provision to the extent possible shall be interpreted and deemed amended so as to avoid such conflict. To the extent of any remaining irreconcilable conflict with this intent, the provision shall be deemed disregarded.
Similarly, any action or election by a Section 16 Person with respect to the Deferral Plan to the extent possible shall be interpreted and deemed amended so as to avoid liability under Section 16 or, if this is not possible, to the extent
necessary to avoid liability under Section 16, shall be deemed ineffective. Notwithstanding anything to the contrary in this Deferral Plan, the provisions of this Deferral Plan may at any time be bifurcated by the Board or the Committee in any
manner so that certain provisions of this Deferral Plan are applicable solely to Section 16 Persons. Notwithstanding any other provision of this Deferral Plan to the contrary, if a distribution which would otherwise occur is prohibited or
proposed to be delayed because of the provisions of Section 16 of the Exchange Act or the provisions of the Deferral Plan designed to ensure compliance with Section 16, the Section 16 Person involved may affirmatively elect in writing
to have the distribution occur in 

  
 22 

 
any event; provided that the Section 16 Person shall concurrently enter into arrangements satisfactory to the Committee in its sole discretion for the satisfaction of any and all
liabilities, costs and expenses arising from this election. 
 10. Securities Laws. This Deferral Plan, allocations to
and from the Company Stock Investment Option and the issuance and delivery of shares of Common Stock and/or other securities or property or the payment of cash under this Deferral Plan, are subject to compliance with all applicable Federal and state
laws, rules and regulations (including but not limited to state and Federal insider trading, registration, reporting and other securities laws and Federal margin requirements) and to such approvals by any listing, regulatory or governmental
authority as may, in the opinion of counsel for the Company be necessary or advisable to comply with all legal requirements. Any securities delivered under this Deferral Plan shall be subject to such restrictions (and the person acquiring such
securities shall, if requested by the Company provide such evidence, assurance and representations to the Company as to compliance with any thereof) as counsel to the Company may deem necessary or desirable to assure compliance with all applicable
legal requirements. 
 11. Electronic Notice and Signatures. Whenever a signature notice or delivery of a document is
required or appropriate under this Deferral Plan, signature, notice or delivery may be accomplished by paper or written format or, to the extent authorized by the Committee, by electronic means. In the event the Committee authorizes electronic means
for the signature, notice or delivery of a document under this Deferral Plan, the electronic record or confirmation of that signature, notice or delivery maintained by or on behalf of the Committee shall for purposes of this Deferral Plan be treated
as if it was a written signature or notice and was delivered in the manner provided herein for a written document. 
 ARTICLE
X 
 EFFECTIVE DATE 
 This Deferral Plan was originally adopted by the Board on July 27, 1995 and became effective upon adoption to awards of Incentive Compensation for the Company’s fiscal year ending
December 31, 1995 and subsequent fiscal years. Subsequent amendments to the Deferral Plan are effective as of the date stated in the amendment or the adopting resolution. 
 This Deferral Plan has been amended and restated effective as of the date stated on the first page herein. 

  
 23 

 APPENDIX A 
 This Appendix A shall govern the portion of a Participant’s Account Balance that was earned and vested prior to January 1, 2005 (and any earnings attributable to that portion). This Appendix A
shall not apply to the portion of a Participant’s Account Balance that is earned or becomes vested on or after January 1, 2005 (and any earnings attributable to that portion). 

ARTICLE I 
 PURPOSES OF THE PLAN 
 The purposes of the Lockheed Martin Corporation
Deferred Management Incentive Compensation Plan (the “Deferral Plan’) are to provide certain key management employees of Lockheed Martin Corporation and its subsidiaries (the “Company”) the opportunity to defer receipt of
(i) Incentive Compensation awards under the Lockheed Martin Corporation Management Incentive Compensation Plan (the “MICP”) and (ii) Long Term Incentive Award payments under the Lockheed Martin Corporation 1995 Omnibus
Performance Award Plan (the “Omnibus Plan”) and the Lockheed Martin Corporation 2003 Incentive Performance Award Plan (the “IPA Plan”). Providing this opportunity to defer income under the Deferral Plan will encourage key
employees to maintain a financial interest in the Company’s performance. Except as expressly provided hereinafter, the provisions of this Deferral Plan and the MICP, the Omnibus Plan and the IPA Plan shall be construed and applied independently
of each other. 
 The Deferral Plan applies solely to MICP awards and Long Term Incentive Award payments under the Omnibus Plan
and the IPA Plan and expressly does not apply to any special awards which may be made under any of the Company’s other incentive plans, except and to the extent specifically provided under the terms of such other incentive plans and the
relevant awards. 
 ARTICLE II 
 DEFINITIONS 
 Unless the context indicates otherwise, the following words
and phrases shall have the meanings hereinafter indicated: 
 1. ACCOUNT — The bookkeeping account maintained by the
Company for each Participant which is credited with the Participant’s Deferred Compensation and earnings (or losses) attributable to the investment options selected by the Participant, and which is debited to reflect distributions and
forfeitures; the portions of a Participant’s Account allocated to different investment options and the portions attributable to the deferral of Incentive Compensation awards and Long Term Incentive Award payments will be accounted for
separately. 

  
 24 

 2. ACCOUNT BALANCE — The total amount credited to a Participant’s Account at any
point in time, including the portions of the Account allocated to each investment option. 
 3. AWARD YEAR — As to
Incentive Compensation, the calendar year with respect to which an Eligible Employee is awarded Incentive Compensation; as to a Long Term Incentive Award payment and the related Company Deferral, the first calendar year in the Performance Period for
which the Long Term Incentive Award is effective with respect to an Eligible Employee. 
 4. BENEFICIARY — The person or
persons (including a trust or trusts) validly designated by a Participant, on the form provided by the Company, to receive distributions of the Participant’s Account Balance, if any, upon the Participant’s death. In the absence of a valid
designation, or if the designated Beneficiary has predeceased the Participant, the Participant’s Beneficiary shall be the personal representative of the Participant’s estate in the event of a Participant’s death. A Participant may
amend his or her Beneficiary designation at any time before the Participant’s death. 
 5. BOARD — The Board of
Directors of Lockheed Martin Corporation. 
 6. COMMITTEE — The committee described in Section 1 of Article VIII.

 7. COMMON STOCK — The $1.00 par value common stock of the Company. 

8. COMPANY — Lockheed Martin Corporation and its subsidiaries. 

9. COMPANY DEFERRALS — The amount deferred by the Company, and not at the election of the Participant, for the two-year period
following the end of a Performance Period for a Long Term Incentive Award. 
 10. COMPANY STOCK INVESTMENT OPTION — The
investment option under which the amount credited to a Participant’s Account will be based on the market value and investment return of the Company’s Common Stock. 
 11. DEFERRAL AGREEMENT — The written agreement executed by an Eligible Employee on the form provided by the Company under which the Eligible Employee elects to defer Incentive Compensation for an
Award Year, or a Long Term Incentive Award and any related Company Deferral for an Award Year. 
 12. DEFERRAL PLAN — The
Lockheed Martin Corporation Deferred Management Incentive Compensation Plan, adopted by the Board on July 27, 1995, and as amended from time to time. 
 13. DEFERRED COMPENSATION — The amount of Incentive Compensation credited to a Participant’s Account under the Deferral Plan and the amount of any Long Term Incentive Award payment credited to a
Participant’s Account under the Deferral Plan (other than Company Deferrals). 

  
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 14. ELIGIBLE EMPLOYEE — An employee of the Company who is a participant in the MICP or
who receives a Long Term Incentive Award under the Omnibus Plan or the IPA Plan and who has satisfied such additional requirements for participation in this Deferral Plan as the Committee may from time to time establish. In the exercise of its
authority under this provision, the Committee shall limit participation in the Plan to employees whom the Committee believes to be a select group of management or highly compensated employees within the meaning of Title I of the Employee Retirement
Income Security Act of 1974, as amended. 
 15. EXCHANGE ACT — The Securities Exchange Act of 1934. 

16. INCENTIVE COMPENSATION — The MICP amount granted to an employee for an Award Year. 

17. IPA PLAN — The Lockheed Martin Corporation 2003 Incentive Performance Award Plan. 

18. INTEREST OPTION — The investment option under which earnings will be credited to a Participant’s Account based on the
interest rate applicable under Cost Accounting Standard 415, Deferred Compensation. 
 19. INVESTMENT FUND OPTION — The
investment option under which earnings (or losses) will be credited to a Participant’s Account based on the market value and investment return of the investment options (including target date funds and core funds (and successor funds), and
excluding the Company Stock Fund, ESOP Fund, and Self-Managed Account) that are available to participants pursuant to the terms of the Qualified Savings Plan, provided that the Committee retains the discretion to add certain funds to, or to exclude
certain funds from, the Investment Fund Option. 
 20. LONG TERM INCENTIVE AWARD — A long term incentive award granted to
an employee under the Omnibus Plan or the IPA Plan. 
 21. MICP — The Lockheed Martin Corporation Management Incentive
Compensation Plan. 
 22. OMNIBUS PLAN — The Lockheed Martin Corporation 1995 Omnibus Performance Award Plan. 

23. PARTICIPANT — An Eligible Employee for whom Incentive Compensation or a Long Term Incentive Award payment has been deferred for
one or more years under this Deferral Plan; the term shall include a former employee whose Deferred Compensation has not been fully distributed. 
 24. PAYMENT DATE — As to any Participant, the January 15 or July 15 on or about on which payment to the Participant is to be made or to begin in accordance with Article V. 

  
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 25. PERFORMANCE PERIOD — The period set forth in a Long Term Incentive Award over
which the Company’s performance is measured by reference to total stockholder return to determine whether any payment will be made under such Long Term Incentive Award. QUALIFIED SAVINGS PLAN — The Lockheed Martin Corporation Salaried
Savings Plan or any successor plan. 
 26. REALLOCATION EFFECTIVE DATE — The date a reallocation elected by a Participant
or Beneficiary under Section 6(a) of Article IV is effected, which shall be the June 30, July 31, August 31 or September 30 immediately following the end of the Reallocation Election Period in which his or her
election under Section 6(a) becomes irrevocable. 
 27. REALLOCATION ELECTION PERIOD — A period in which a
Participant or Beneficiary may under Section 6(a) of Article IV elect a reallocation of his or her Account Balance from one investment option to another investment option, and there shall be four such election periods: June 1 through
June 15, 2004, June 16 through July 15, 2004, July 16 through August 15, 2004 and August 16 through September 15, 2004. 
 28. SECTION 16 PERSON — A Participant who is subject to the reporting and short-swing liability provisions of Section 16 of the Securities Exchange Act of 1934 on the date a Deferral Agreement
or other election form is delivered to the Company in accordance with the terms of this Deferral Plan. 
 29. SUBSIDIARY —
As to any person, any corporation, association, partnership, joint venture or other business entity of which 50% or more of the voting stock or other equity interests (in the case of entities other than corporation), is owned or controlled (directly
or indirectly) by that entity, or by one or more of the Subsidiaries of that entity, or by a combination thereof. 
 30.
TRADING DAY — A day upon which transactions with respect to Company Common Stock are reported in the consolidated transaction reporting system. 
 ARTICLE III 
 ELECTION OF DEFERRED AMOUNT 

1. Timing of Deferral Elections. 
 (a) Incentive Compensation. An Eligible Employee may elect to defer Incentive Compensation for an Award Year by executing and delivering to the Company a Deferral Agreement no later than
October 31 of the Award Year, provided that any election by a Section 16 Person shall be subject to the provisions of Section 4 of Article IV. 
 (b) Long Term Incentive Awards and Company Deferrals. An Eligible Employee may elect to defer the payment of a Long Term Incentive Award and a Company Deferral for an Award Year by executing and
delivering to the Company a Deferral 

  
 27 

 
Agreement no later than October 31 of the Award Year, provided that any election by a Section 16 Person shall be subject to the provisions of Section 4 of Article IV. 

(c) Irrevocability of Elections. No Eligible Employee shall have the right to modify or revoke a Deferral Agreement for an Award
Year after the applicable deadline described in Section 1(a) and Section 1(b) of this Article III for delivering a Deferral Agreement to the Company for such Award Year, provided no Section 16 Person shall have the right to modify or
revoke a Deferral Agreement after such applicable deadline or, if earlier, after the date the agreement has been delivered to the Company. The Committee may establish policies and procedures to determine when a Deferral Agreement or other election
called for under this Plan has been delivered to the Company. Each Deferral Agreement shall apply only to amounts deferred in that Award Year and a separate Deferral Agreement must be completed for each Award Year for which an Eligible Employee
defers Incentive Compensation or a Long Term Incentive Award. 
 2. Amount of Deferral Elections. An Eligible
Employee’s deferral election may be stated as: 
 (a) a dollar amount which is at least $5,000 and is an even multiple of
$1,000, 
 (b) the greater of $5,000 or a designated percentage of the Eligible Employee’s Incentive Compensation or Long
Term Incentive Award payment (adjusted to the next highest multiple of $1,000), 
 (c) the excess of the Eligible
Employee’s Incentive Compensation or Long Term Incentive Award payment over a dollar amount specified by the Eligible Employee (which must be an even multiple of $1,000), or 

(d) all of the Eligible Employee’s Incentive Compensation or Long Term Incentive Award payment. 

An Eligible Employee’s deferral election shall be effective only if the Participant is awarded, in the case of Incentive Compensation, at least
$10,000 of Incentive Compensation for that Award Year, or in the case of Long Term Incentive Award, at least $10,000 is payable to the Participant in cash at the conclusion of the Performance Period applicable to a Long Term Incentive Award payment.
In addition, in the case of a deferral election under paragraph (c) of this Section 2, an Eligible Employee’s deferral election shall be effective only if the resulting excess amount is at least $5,000. 

3. Effect of Taxes on Deferred Compensation. The amount that would otherwise be deferred and credited to an Eligible
Employee’s Account will be reduced by the amount of any tax that the Company is required to withhold with respect to the Deferred Compensation. The reduction for taxes shall be made proportionately out of amounts otherwise allocable to the
Interest Option and the Company Stock Investment Option. 
 4. Multiple Awards. In the case of an Eligible Employee who
receives more than one Long Term Incentive Award with respect to the same Performance Period, the 

  
 28 

 
elections made by the Eligible Employee under this Article III as well as under Articles V and VI for the first Long Term Incentive Award granted to the Eligible Employee with respect to a
Performance Period shall be deemed to be the elections made by that Eligible Employee for any other Long Term Incentive Awards granted to that Eligible Employee with respect to that same Performance Period. 

5. Company Deferrals. Pursuant to the terms of the Long Term Incentive Awards, 50% of the amount payable at the end of the
Performance Period will be automatically deferred until the second anniversary of the last day of the Performance Period with respect to a particular award. The Company may establish an account for Company Deferrals under the Company Stock
Investment Option of this Deferral Plan. However, the terms governing the Company Deferrals will be governed for the two year period of deferral by the terms of the award agreement entered into under the Omnibus Plan or the IPA Plan with respect to
the Long Term Incentive Award and not by this Deferral Plan except to the extent the award agreement expressly refers to the terms of this Deferral Plan. Notwithstanding the foregoing, if the Participant elects to defer the Company Deferrals beyond
the second anniversary of the end of the Performance Period, the deferrals will be treated as made under this Deferral Plan for the period following the second anniversary of the end of the Performance Period. 

ARTICLE IV 

CREDITING OF ACCOUNTS 
 1. Crediting of Deferred Compensation. Incentive Compensation or a Long Term Incentive Award payment that a Participant has elected to defer under this Deferral Plan shall be credited to the
Participant’s Account as of the Trading Day set by action of the Committee or, if the Committee does not act to set such a day, on the second Trading Day which follows the date of approval of the related Incentive Compensation or Long Term
Incentive Award. If the Company establishes an account for Company Deferrals pursuant to Section 5 of Article III, the Company Deferrals shall be credited to such account as of the last Trading Day in the Performance Period. Any Deferred
Compensation credits under this Section 1 which are allocable to the Interest Option shall be credited at the dollar amount of such credits. Any Deferred Compensation and Company Deferral credits under this Section 1 which are allocable to
the Company Stock Investment Option shall be credited as if the dollar amount of credits had been invested in the Company’s Common Stock at the published closing price of the Company’s Common Stock on the applicable Trading Day described
in this Section 1. Any Deferred Compensation and Company Deferral credits under this Section 1 which are allocable to the Investment Fund Option shall be credited as if the dollar amount of credits had been invested in the applicable fund
at the published closing price of the applicable fund on the applicable Trading Day described in this Section 1. 
 2.
Crediting of Earnings (Losses) and Reallocations. 
 (a) General Rules. 

  
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 (i) Earnings (or losses) shall be credited to a Participant’s Account
based on the investment option or options to which the Account has been allocated beginning with the applicable Trading Day described in this Article IV. 
 (ii) Earnings (or losses) on amounts reallocated in accordance with this Article IV shall be credited to the Participant’s Account as of the applicable day or Trading Day described for such
reallocation in this Article IV. 
 (iii) Any amount distributed from a Participant’s Account in cash
pursuant to Article V shall be credited with earnings (or losses) through the Trading Day that is four (4) business days prior to the Payment Date on which a distribution is to be made. Any amount distributed from a Participant’s Account
in stock pursuant to Article V shall be credited with earnings (or losses) through the last Trading Day preceding the date on which a distribution is to be made. 

(iv) Company Deferrals shall be credited with earnings (or losses) through the last Trading Day in the period which ends
on the second anniversary of the end of the applicable Performance Period unless deferred further pursuant to a Deferral Agreement. 
 (b) Interest Option. The portion of a Participant’s Account allocated or reallocated to the Interest Option shall be credited with interest, valued daily, while so allocated or reallocated at
a rate equivalent to the then published rate for computing the present value of future benefits at the time cost is assignable under Cost Accounting Standard 415, Deferred Compensation, as determined by the Secretary of the Treasury on a semi-annual
basis pursuant to Pub. L. 92-41, 85 Stat. 97. No amounts may be reallocated to the Interest Option on or after July 1, 2009. Amounts deferred prior to January 1, 2005 may remain invested in the Interest Option until such amounts are
transferred to the Company Stock Investment Option or the Investment Fund Option on or after July 1, 2009. 

(c) Company Stock Investment Option. 

(i) The portion of a Participant’s Account allocated or reallocated to the Company Stock Investment Option shall be
credited when so allocated or reallocated on the applicable Trading Day described in this Article IV as if such amount had been invested in the Company’s Common Stock at the published closing price of the Company’s Common Stock on such
Trading Day. 
 (ii) The portion of the Participant’s Account Balance allocated to the Company Stock
Investment Option shall reflect any post-allocation appreciation or depreciation in the market value of the Company’s Common Stock based on the published closing price of the stock on each Trading Day and shall reflect dividends paid and any
other distributions made with respect to the Company’s Common Stock. 
 (iii) Cash dividends shall be
treated as if such dividends had been reinvested in the Company’s Common Stock at the published closing price of the 

  
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Company’s Common Stock on the Trading Day on which the cash dividend is paid or, if the dividend is paid on a day which is not a Trading Day, on the Trading Day which immediately precedes
the day the dividend is paid. 
 (iv) If any portion of a Participant’s Account was reallocated in
accordance with paragraph 5 (or paragraph 4 prior to October 1, 2004) of this Article IV from the Company Stock Investment Option to the Interest Option or the , the reallocation shall be credited to the Interest Option as if the Company’s
Common Stock had been bought or sold at the published closing price of the Company’s Common Stock on the Trading Day on which the reallocation is effective, or if the reallocation is effective as of the day that is not a Trading Day, the
Trading Day which immediate precedes the effective date of the reallocation. 
 (d) Investment Fund
Option. Earnings (or losses) shall be credited to a Participant’s Account based on the investment option or options within the Investment Fund Option to which his or her Account has been allocated. The manner in which earnings (or losses)
are credited under each of the investment options shall be determined in the same manner as under the Qualified Savings Plan. The procedures for directing the allocation and reallocation among the investment options in the Investment Fund Option
shall be the same as the procedures for making allocations under the Qualified Savings Plan. 
 3. Election of Investment
Options. A Participant’s initial investment elections for a particular type of award for an Award Year shall be made in his or her Deferral Agreement for such Award Year, and no Participant shall (except as provided for in Section 6
and Section 7 of this Article IV) have the right to modify or revoke any such election after the time the Participant no longer has the right to modify or revoke a Deferral Agreement under Section 1 of Article III. A Participant’s
allocations between investment options shall be subject to such minimum allocations as the Committee may establish. 
 4.
Special Rule for Section 16 Persons. An election by a Section 16 Person to have any Deferred Compensation allocated to the Company Stock Investment Option shall be effective on the Trading Day described in Section 1 of this
Article IV unless he or she delivers the related Deferral Agreement to the Company less than six months before such Trading Day. If he or she delivers the related Deferral Agreement to the Company less than six months before such date, his or her
Company Stock Investment Option election automatically shall be treated as an Interest Option election under Section 1 of this Article IV until the first Trading Day of the seventh month following the month in which the Deferral Agreement is
delivered to the Company. The Deferred Compensation so allocated to the to the Interest Option together with any related interest credits shall by operation of this Deferral Plan automatically be reallocated and credited to the Company Stock
Investment Option on such Trading Day in accordance with Section 2(b) of this Article IV. 
 Reallocations to Interest
Option (deleted effective September 30, 2004). If benefit payments to a Participant or Beneficiary are to be paid or commenced to be paid over a period that extends more than six months after the date of the Participant’s termination
of employment with the Company, the Participant or Beneficiary, as applicable, may make a one-time 

  
 31 

 
irrevocable election under this Section 5 at any time after the Participant’s termination of employment and before the completion of benefit payments to have the portion of the
Participant’s Account that is allocated to the Company Stock Investment Option reallocated to the Interest Option. A reallocation under this Section 5 shall take effect as of the first Trading Day of the month following the month in which
an executed reallocation election is delivered to the Company, provided an election by a Participant or Beneficiary who is a Section 16 Person on the date the election is delivered to the Company shall be effective only if such election
satisfies on such date all the requirements of the exemption under Rule l6b-3 of the Exchange Act for a “discretionary transaction” or otherwise would not result in a short swing profit recovery pursuant to Rule 16b-3 under the Exchange
Act. In the event such election does not satisfy the exemption pursuant to Rule l6b-3 under the Exchange Act for a “discretionary transaction” and if giving effect to the election would result in liability under Section 16(b) of the
Exchange Act, the election shall not be given effect until the first Trading Day of the month following the month in which the election could be given effect without creating liability under Section 16(b) of the Exchange Act. Notwithstanding
anything herein to the contrary, no election may be made under this Section 5 after September 15, 2004, and any such election made during September 2004 will be valued and take effect as of September 30, 2004. 

5. One-Time Reallocation Right. 
 (a) General Rule. Subject to Section 5(b) of this Article IV, a Participant or Beneficiary may during a Reallocation Election Period execute and deliver to the Company an election made on such
form and in such manner as prescribed by the Committee to the Company to reallocate all or a portion (in five (5) percent increments) of his or her Account Balance (other than Company Deferrals) which is then allocated to one investment option
to the other investment option. Any such election shall be irrevocable when received by the Company, and the reallocation which the Participant or Beneficiary elects shall be effective as of the Reallocation Effective Date that immediately follows
the end of the Reallocation Election Period in which his or her election becomes irrevocable. Only one reallocation election may be made by a Participant or Beneficiary with the result that a reallocation made in one Reallocation Election Period
will preclude a reallocation election in a subsequent Reallocation Election Period. 
 (b) Exception. If a Participant or
a Beneficiary is a Section 16 Person on any date in a Reallocation Election Period and delivers an election to the Company in such period, such election shall have no force or effect under Section 6(a) unless such election complies with
the exemption under Rule l6b-3 of the Exchange Act for a “discretionary transaction”. 
 (c) Additional Credit.
The Company shall credit to the Account of each Participant or Beneficiary that has Deferred Compensation (other than Company Deferrals) credited to the Stock Investment Option as of September 30, 2004 an amount equal to the greater of
(i) $24.95 per Account Balance; or (ii) $0.10 for each whole share of Common Stock reflected in the Participant’s or Beneficiary’s Account Balance (exclusive of Company Deferrals). Such amount shall be allocated and credited to
the Interest Option as of September 30, 2004, after taking into account any reallocation under Section 6(a) of this Article IV. 

  
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 6. Reallocation Among Investment Options. Effective June 16, 2008, a
Participant may reallocate the portion of his Account Balance that is invested in the Interest Option and the Investment Fund Option to the Interest Option (through June 30, 2009), the Company Stock Investment Option, and the various investment
funds in the Investment Fund Option, subject to the trading restrictions that apply to the transfer and reallocation of investments under the terms of the Qualified Savings Plan, applied as if such Qualified Savings Plan restrictions also pertain to
the Interest Option; provided that a Participant may not at any time reallocate the portion of his Account Balance that is invested at any time in the Company Stock Investment Option. Notwithstanding the foregoing, any election by a Section 16
Person to reallocate any portion of his Account Balance to the Company Stock Investment Option shall only become effective if the election is made at least six months following the most recent election with respect to any plan of the Corporation
that involved the disposition of the Corporation’s equity securities pursuant to a “Discretionary Transaction” (as defined in Exchange Act Rule 16b-3). . No amounts may be reallocated to the Interest Option on or after July 1,
2009. 
 ARTICLE V 
 PAYMENT OF BENEFITS 
 1. General. 

(a) Account Balance and Elections. The Company’s liability to pay benefits to a Participant or Beneficiary under this
Deferral Plan shall be measured by and shall in no event exceed the Participant’s Account Balance. Except as otherwise provided in this Deferral Plan (including but not limited to Section 5 of Article III with respect to Company
Deferrals), a Participant’s Account Balance shall be paid to him in accordance with the Participant’s elections under this Article V. 
 (b) Cash Only Payment. With respect to benefit payments made on a Payment Date which is on or before September 30, 2004, all such benefit payments shall be made in accordance with the terms of
this Deferral Plan as in effect on such date in cash and, except as otherwise provided under such terms, shall reduce allocations to the Interest Option and the Company Stock Investment Option in the same proportions that the Participant’s
Account Balance is allocated between those investment options at the end of the month preceding the date of distribution. Notwithstanding the foregoing, no amount of Deferred Compensation shall be distributed to a Section 16 Person under this
Deferral Plan which is attributable to the Stock Investment Option unless such amount was allocated to the Participant’s Account in accordance with Section 1 of Article 4 at least six months prior to the date of distribution or no portion
of such amount was allocated to the Company Stock Investment Option in the six months prior to distribution. 
 (c) Cash and
Stock Payments. With respect to benefit payments made after September 30, 2004, all such benefit payments shall be made in cash to the extent a Participant’s Account is allocated to the Interest Option or Investment Fund Option or is
attributable to Company Deferrals and shall be made in whole shares of the Company’s Common Stock to the 

  
 33 

 
extent that a Participant’s Account is allocated to the Company Stock Investment Option (other than with respect to Company Deferrals) and, except as otherwise provided, shall reduce
allocations to the Interest Option, the Investment Fund Option, and the Company Stock Investment Option in the same proportions that the Participant’s Account Balance is allocated between those investment options at the end of the month
preceding the date of distribution (for distributions occurring prior to June 16, 2008) or the Trading Day that is four (4) business days prior to the date of the distribution (for distributions occurring on or after June 16, 2008).
Notwithstanding the foregoing, no amount of Deferred Compensation shall be distributed to a Section 16 Person under this Deferral Plan unless such amount was allocated to the Participant’s Account in accordance with Section 1 of
Article 4 at least six months prior to the date of distribution. At the Company’s discretion a distribution of Common Stock may be made directly to a Participant or to a brokerage account opened in the name of the Participant. When an Account
is distributed in a lump sum or, if an Account is distributed in installments, when the final installment is made, cash shall be distributed (or withheld for applicable taxes) at that time in lieu of any fractional share of Common Stock. The cash
distribution in lieu of fractional shares shall be based on the published closing price of the Company’s Common Stock on the last Trading Day preceding the date the distribution is scheduled to be made. 

2. Election for Commencement of Payment. At the time a Participant first completes a Deferral Agreement, he or she shall elect
from among the following options governing the date on which the payment of benefits shall commence: 
 (a) Payment to begin on
the Payment Date next following the date of the Participant’s termination of employment with the Company for any reason. 

(b) Payment to begin on the first Payment Date of the year next following the year in which the Participant terminates employment with
the Company for any reason. 
 (c) Payment to begin on the Payment Date next following the date on which the Participant has
both terminated employment with the Company for any reason and attained the age designated by the Participant in the Deferral Agreement. 

Notwithstanding a Participant’s election, any payment of benefits in the form of shares of Common Stock that would otherwise commence within six
months of the date on which a Participant ceased to be Section 16 Person shall not be paid on that date but instead shall be paid on the first Payment Date that is at least six months after the date on which that Participant ceased to be a
Section 16 Person. 
 3. Election for Form of Payment. At the time a Participant first completes a Deferral
Agreement, he or she shall elect the form of payment of his or her Account Balance from among the following options: 
  

	 	(A)	A lump sum. 

  

	 	(B)	 Annual installment payments for a period of years designated by the Participant, which shall not exceed fifteen (15) annual installments. The
amount of each annual payment shall be determined by dividing the Participant’s Account Balance at the 

  
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end of the month prior to such payment by the number of installment payments then remaining in the designated installment period. The installment period may be shortened, in the sole discretion
of the Committee, if the Committee at any time determines that the amount of the annual payments that would be made to the Participant during the designated installment period would be too small to justify the maintenance of the Participant’s
Account and the processing of payments. 

 4. Prospective Change of Payment Elections. 

(a) Notwithstanding anything to the contrary in this Article V, a Participant may make an election with respect to the commencement of
payment (from among the options set forth in Section 2(A), (B), or (C) above) and form of payment (from among the options set forth in Section 3(A) or (B) above) of his or her entire Account Balance, or with respect to specific
Award Years, by executing and delivering to the Company an election form on or after October 1, 2002 in such form as prescribed by the Company. If a Participant has different payment options in effect with respect to his or her Account Balance,
the Company shall maintain sub-accounts for the Participant to determine the amounts subject to each payment election; however, no election or modification of an election will be accepted if it would require the Company to maintain more than five
sub-accounts within the Participant’s Account in order to make payments in accordance with the Participant’s elections. 
 (b) In the event a Participant does not make a valid election with respect to the commencement of payment and form of benefit for an Award Year commencing on or after October 1, 2002, the Participant
will be deemed to have elected that payment of benefits with respect to that Award Year be made in a lump sum on or about the Payment Date next following the date of the Participant’s termination of employment. 

(c) A Participant’s election with respect to an Award Year (including a “deemed election” in accordance with the preceding
paragraph) shall remain in effect unless and until such election is modified by a subsequent election in accordance with the second preceding paragraph above. 
 (d) To constitute a valid election by a Participant making a prospective change to a previous election, the prospective election must be executed and delivered to the Company (i) at least six months
before the date the first payment would be due under the Participant’s previous election and (ii) in a different calendar year than the date the first payment would be due under the Participant’s previous election. In the event an
election fails to satisfy the provisions set forth in this paragraph, such election shall be void and, if such an election is void, payment shall be made in accordance with the most recent election which was valid. In addition, no prospective
election will be considered valid to the extent the prospective election would (i) result in a payment being made within six months of the date of the prospective election or (ii) result in a payment under the prospective election in the
same calendar year as the date of the prospective election. In the event a prospective election fails to satisfy the provisions set forth in the preceding sentence, the first payment under the prospective election will be

  
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delayed until the first Payment Date that is both (i) at least six months after the date of the prospective election and (ii) in a calendar year after the date of the prospective
election. 
 (e) A Participant may not make or modify an election with respect to commencement of payment or form of payment
after the date a Participant terminates employment. 
 5. Acceleration upon Early Termination. Notwithstanding a
Participant’s payment elections under this Article V, if the Participant terminates employment with the Company other than by reason of layoff, death or disability and before the Participant is eligible to commence receiving retirement benefits
under a pension plan maintained by the Company (or before the Participant has attained age 55 if the Participant does not participate in such a pension plan), except as provided in Section 5 of Article III with respect to Company Deferrals, the
Participant’s Account Balance shall be distributed to him or her in a lump sum on or about the Payment Date next following the date of the Participant’s termination of employment with the Company; provided, however, that if a distribution
in accordance with the provisions of this Section 5 would otherwise result in a nonexempt short-swing transaction under Section 16(b) of the Exchange Act, the date of distribution with respect to any Section 16 Person shall be delayed
until the earliest date upon which the distribution either would not result in a nonexempt short-swing transaction or would otherwise not result in liability under Section 16(b) of the Exchange Act. 

6. Acceleration Upon Conflict of Interest. Notwithstanding a Participant’s payment elections under this Article V, if
following a Participant’s termination of employment with the Company, the Participant takes a position (or accepts a position) with a governmental entity, agency, or instrumentality and that employer has determined or indicated that the
Participant’s continued participation in the Plan may constitute a conflict of interest precluding the Participant from continuing in his position (or from accepting an offered position) with that employer or subjecting the Participant to
penalty, sanction, or otherwise limiting the Participant’s responsibilities for that employer, except as provided in Section 5 of Article III with respect to Company Deferrals, then the Participant’s Account Balance shall be
distributed to him or her in a lump sum as soon as practical following the later of (i) the date on which the Participant commences employment with the government employer; or (ii) the date on which it is determined or indicated that the
conflict of interest may exist. This Section 6 shall be applicable only to the extent that such distribution conforms to Code section 409A. 
 7. Death Benefits. 
 (a) General Rule. Upon the death of a
Participant before a complete distribution of his or her Account Balance, the Account Balance will be paid to the Participant’s Beneficiary in accordance with the payment elections applicable to the Participant. If a Participant dies while
actively employed or otherwise before the payment of benefits has commenced, payments to the Beneficiary shall commence on the date payments to the Participant would have commenced, taking account of the Participant’s termination of employment
(by death or before) and, if applicable, by postponing commencement until after the date the Participant would have attained the commencement age specified by the Participant. 

  
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Whether the Participant dies before or after the commencement of distributions, payments to the Beneficiary shall be made for the period or remaining period elected by the Participant.

 (b) Special Rule. Notwithstanding Section 7(a) of this Article V, in the event that a Participant dies before the
Participant’s entire Account Balance has been distributed, the Committee, in its sole discretion, may modify the timing of distributions from the Participant’s Account, including the commencement date and number of distributions, if it
concludes that such modification is necessary to relieve the financial burdens of the Participant’s Beneficiary; provided, however, that if a distribution in accordance with the provisions of this Section 7(b) from the portion of the
Participant’s Account allocated to the Company Stock Investment Option would otherwise result in a nonexempt short-swing transaction under Section 16(b) of the Exchange Act, the date of distribution with respect to such portion to any
Section 16 Person shall be delayed until the earliest date upon which the distribution either would not result in a nonexempt short-swing transaction or would otherwise not result in liability under Section 16(b) of the Exchange Act.

 8. Early Distributions in Special Circumstances. Notwithstanding a Participant’s payment elections under this
Article V, a Participant or Beneficiary may request an earlier distribution in the following limited circumstances (except as provided in Section 5 of Article III with respect to Company Deferrals): 

(a) Hardship Distributions. A Participant may apply for a hardship distribution pursuant to this Section 8(a)
on such form and in such manner as the Committee shall prescribe and, subject to the last sentence of this Section 8(a) with respect to Section 16 Persons, the Committee shall have the power and discretion at any time to approve a payment
to a Participant if the Committee determines that the Participant is suffering from a serious financial emergency caused by circumstances beyond the Participant’s control which would cause a hardship to the Participant unless such payment were
made. Any such hardship payment will be in a lump sum and will not exceed the lesser of (i) the amount necessary to satisfy the financial emergency (taking account of the income tax liability associated with the distribution), or (ii) the
Participant’s Account Balance; provided, however, that if a distribution in accordance with the provisions of this Section 8(a) from the portion of the Participant’s Account allocated to the Company Stock Investment Option would
otherwise result in a nonexempt short-swing transaction under Section 16(b) of the Exchange Act, the date of distribution with respect to such portion to such Section 16 Person shall be delayed until the earliest date upon which the
distribution either would not result in a nonexempt short-swing transaction or would otherwise not result in liability under Section 16(b) of the Exchange Act. 

(b) Withdrawal with Forfeiture. A Participant may elect on such form and in such manner as the Committee shall
prescribe at any time to withdraw ninety percent (90%) of the amount credited to the Participant’s Account. If such a withdrawal is made, the remaining ten percent (10%) of the Participant’s Account shall be permanently
forfeited, and the Participant will be prohibited from deferring any amount under the Deferral Plan for the Award Year in which 

  
 37 

 
the withdrawal is received (or the first Award Year in which any portion of the withdrawal is received); provided, however, that if a distribution in accordance with the provisions of this
Section 8(b) from the portion of the Participant’s Account allocated to the Company Stock Investment Option would otherwise result in a nonexempt short-swing transaction under Section 16(b) of the Exchange Act, the date of
distribution with respect to such portion to any Section 16 Person shall be delayed until the earliest date upon which the distribution either would not result in a nonexempt short-swing transaction or would otherwise not result in liability
under Section 16(b) of the Exchange Act. 
 (c) Disability. If the Committee determines that a
Participant has become permanently disabled before the Participant’s entire Account Balance has been distributed, the Committee, in its sole discretion, may modify the timing of distributions from the Participant’s Account, including the
commencement date and number of distributions, if it concludes that such modification is necessary to relieve the financial burdens of the Participant; provided, however, that if a distribution in accordance with the provisions of this
Section 8(c) from the portion of the Participant’s Account allocated to the Company Stock Investment Option would otherwise result in a nonexempt short-swing transaction under Section 16 (b) of the Exchange Act, the date of
distribution with respect to such portion to any Section 16 Person shall be delayed until the earliest date upon which the distribution either would not result in a nonexempt short-swing transaction or would otherwise not result in liability
under Section 16(b) of the Exchange Act. 
 9. Acceleration upon Change in Control. 

(a) Notwithstanding any other provision of the Deferral Plan, except as provided in Section 5 of Article III with
respect to Company Deferrals, the Account Balance of each Participant shall be distributed in a single lump sum within fifteen (15) calendar days following a “Change in Control.” 

(b) For purposes of this Deferral Plan, a Change in Control shall include and be deemed to occur upon the following
events: 
 (1) A tender offer or exchange offer is consummated for the ownership of securities of the Company
representing 25% or more of the combined voting power of the Company’s then outstanding voting securities entitled to vote in the election of directors of the Company. 

(2) The Company is merged, combined, consolidated, recapitalized or otherwise reorganized with one or more other entities
that are not Subsidiaries and, as a result of the merger, combination, consolidation, recapitalization or other reorganization, less than 75% of the outstanding voting securities of the surviving or resulting corporation shall immediately after the
event be owned in the aggregate by the stockholders of the Company (directly or indirectly), determined on the basis of record ownership as of the date of determination of holders 

  
 38 

 
entitled to vote on the action (or in the absence of a vote, the day immediately prior to the event) 
 (3) Any person (as this term is used in Sections 3(a)(9) and 13(d)(3) of the Exchange Act, but excluding any person described in and satisfying the conditions of Rule 13d-1 (b)(1) thereunder), becomes the
beneficial owner (as defined in Rule 13d-3 under the Exchange Act), directly or indirectly, of securities of the Company representing 25% or more of the combined voting power of the Company’s then outstanding securities entitled to vote in the
election of directors of the Company. 
 (4) At any time within any period of two years after a tender offer,
merger, combination, consolidation, recapitalization, or other reorganization or a contested election, or any combination of these events, the “Incumbent Directors” shall cease to constitute at least a majority of the authorized number of
members of the Board. For purposes hereof, “Incumbent Directors” shall mean the persons who were members of the Board immediately before the first of these events and the persons who were elected or nominated as their successors or
pursuant to increases in the size of the Board by a vote of at least three-fourths of the Board members who were then Board members (or successors or additional members so elected or nominated) 

(5) The stockholders of the Company approve a plan of liquidation and dissolution or the sale or transfer of
substantially all of the Company’s business and/or assets as an entirety to an entity that is not a Subsidiary. 
 (c) Notwithstanding the provisions of Section 9(a), if a distribution in accordance with the provisions of Section 9(a) would result in a nonexempt short-swing transaction under
Section 16(b) of the Exchange Act with respect to any Section 16 Person, then the date of distribution to such Section 16 Person shall be delayed until the earliest date upon which the distribution either would not result in a
nonexempt short-swing transaction or would otherwise not result in liability under Section 16(b) of the Exchange Act. 
 (d) This Section 9 shall apply only to a Change in Control of Lockheed Martin Corporation and shall not cause immediate payout of Deferred Compensation in any transaction involving the Company’s
sale, liquidation, merger, or other disposition of any subsidiary. 
 (e) The Committee may cancel or modify
this Section 9 at any time prior to a Change in Control. In the event of a Change in Control, this Section 9 shall remain in force and effect, and shall not be subject to cancellation or modification for a period of five years, and any
defined term used in Section 9 shall not, for purposes of Section 9, be subject to cancellation or modification during the five-year period. 

  
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 10. Deductibility of Payments. In the event that the payment of benefits in
accordance with the Participant’s elections under this Article V would prevent the Company from claiming an income tax deduction with respect to any portion of the benefits paid, the Committee shall have the right to modify the timing of
distributions from the Participant’s Account as necessary to maximize the Company’s tax deductions. In the exercise of its discretion to adopt a modified distribution schedule, the Committee shall undertake to have distributions made at
such times and in such amounts as most closely approximate the Participant’s elections, consistent with the objective of maximum deductibility for the Company. The Committee shall have no authority to reduce a Participant’s Account Balance
or to pay aggregate benefits less than the Participant’s Account Balance in the event that all or a portion thereof would not be deductible by the Company. 
 11. Change of Law. Notwithstanding anything to the contrary herein, if the Committee determines in good faith, based on consultation with counsel, that the Federal income tax treatment or legal
status of the Plan has or may be adversely affected by a change in the Code, Title I of the Employee Retirement Income Security Act of 1974, or other applicable law or by an administrative or judicial construction thereof, the Committee may direct
that the Accounts of affected Participants or of all Participants be distributed as soon as practicable after such determination is made, to the extent deemed necessary or advisable by the Committee to cure or mitigate the consequences, or possible
consequences of, such change in law or interpretation thereof. 
 12. Tax Withholding. To the extent required by law,
the Company shall withhold from benefit payments hereunder, or with respect to any Incentive Compensation or Long Term Incentive Award payment deferred hereunder or credit contributed by the Company under Article IV, any Federal, state, or local
income or payroll taxes required to be withheld and shall furnish the recipient and the applicable government agency or agencies with such reports, statements, or information as may be legally required. 

ARTICLE VI 

EXTENT OF PARTICIPANTS’ RIGHTS 
 1. Unfunded Status of Plan. This Deferral Plan constitutes a mere contractual promise by the Company to make payments in the future, and each Participant’s rights shall be those of a general,
unsecured creditor of the Company. No Participant shall have any beneficial interest in any specific assets that the Company may hold or set aside in connection with this Deferral Plan. Notwithstanding the foregoing, to assist the Company in meeting
its obligations under this Deferral Plan, the Company may set aside assets in a trust described in Revenue Procedure 92-64, 1992-2 C.B. 422, and the Company may direct that its obligations under this Deferral Plan be satisfied by payments out of
such trust. The assets of any such trust will remain subject to the claims of the general creditors of the Company. It is the Company’s intention that the Deferral Plan be unfunded for Federal income tax purposes and for purposes of Title I of
the Employee Retirement Income Security Act of 1974. 
 2. Nonalienability of Benefits. A Participant’s rights
under this Deferral Plan shall not be assignable or transferable and any purported transfer, assignment, pledge or 

  
 40 

 
other encumbrance or attachment of any payments or benefits under this Deferral Plan, or any interest therein shall not be permitted or recognized, other than the designation of, or passage of
payment rights to, a Beneficiary. Notwithstanding, any portion of a Participant’s benefit under this Plan may be paid to a spouse or former spouse pursuant to the terms of a domestic relations order (as defined in Code section 414(p)(1)(B)),
provided that the form of payment designated in such order is one that is provided for under Section 3 of Article V of this Deferral Plan. 
 ARTICLE VII 
 AMENDMENT OR TERMINATION 

1. Amendment. The Board or its authorized delegate may amend, modify, suspend or discontinue this Deferral Plan at any time
subject to any shareholder approval that may be required under applicable law, provided, however, that no such amendment shall have the effect of reducing a Participant’s Account Balance or postponing the time when a Participant is entitled to
receive a distribution of his Account Balance. Further, no amendment may alter the formula for crediting interest to Participants’ Accounts with respect to amounts for which deferral elections have previously been made, unless the amended
formula is not less favorable to Participants than that previously in effect, or unless each affected Participant consents to such change. 
 2. Termination. The Board reserves the right to terminate this Plan at any time and to pay all Participants their Account Balances in a lump sum immediately following such termination or at such
time thereafter as the Board may determine; provided, however, that if a distribution in accordance with the provisions of this Section 2 would otherwise result in a nonexempt short-swing transaction under Section 16(b) of the Exchange
Act, the date of distribution with respect to any Section 16 Person shall be delayed until the earliest date upon which the distribution either would not result in a nonexempt short-swing transaction or would otherwise not result in liability
under Section 16(b) of the Exchange Act. 
 3. Transfer of Liability. The Board reserves the right to transfer to
another entity all of the obligations of Company with respect to a Participant under this Plan if such entity agrees pursuant to a binding written agreement to assume all of the obligations of the Company under this Plan with respect to such
Participant. 
 ARTICLE VIII 
 ADMINISTRATION 
 1. The Committee. This Deferral Plan shall be
administered by the Compensation Committee of the Board or such other committee of the Board as may be designated by the Board and constituted so as to permit this Deferral Plan to comply with the disinterested administration requirements of Rule
16b-3 of the Exchange Act. The members of the Committee shall be designated by the Board. A majority of the members of the Committee (but not fewer than two) shall constitute a quorum. The vote of a majority of a quorum or the unanimous written
consent of the Committee shall constitute action by the Committee. The 

  
 41 

 
Committee or its delegate shall have full authority to interpret the Plan, and interpretations of the Plan by the Committee or its delegate shall be final and binding on all parties. 

2. Delegation and Reliance. The Committee may delegate to the officers or employees of the Company the authority to execute and
deliver those instruments and documents, to do all acts and things, and to take all other steps deemed necessary, advisable or convenient for the effective administration of this Deferral Plan in accordance with its terms and purpose, except that
the Committee may not delegate any authority the delegation of which would cause this Deferral Plan to fail to satisfy the applicable requirements of Rule 16b-3. In making any determination or in taking or not taking any action under this Deferral
Plan, the Committee may obtain and rely upon the advice of experts, including professional advisors to the Company. No member of the Committee or officer of the Company who is a Participant hereunder may participate in any decision specifically
relating to his or her individual rights or benefits under the Deferral Plan. 
 3. Exculpation and Indemnity. Neither
the Company nor any member of the Board or of the Committee, nor any other person participating in any determination of any question under this Deferral Plan, or in the interpretation, administration or application thereof, shall have any liability
to any party for any action taken or not taken in good faith under this Deferral Plan or for the failure of the Deferral Plan or any Participant’s rights under the Deferral Plan to achieve intended tax consequences, to qualify for exemption or
relief under Section 16 of the Exchange Act and the rules thereunder, or to comply with any other law, compliance with which is not required on the part of the Company. 
 4. Facility of Payment. If a minor, person declared incompetent, or person incapable of handling the disposition of his or her property is entitled to receive a benefit, make an application, or
make an election hereunder, the Committee or its delegate may direct that such benefits be paid to, or such application or election be made by, the guardian, legal representative, or person having the care and custody of such minor, incompetent, or
incapable person. Any payment made, application allowed, or election implemented in accordance with this Section shall completely discharge the Company and the Committee (or its delegate) from all liability with respect thereto. 

5. Proof of Claims. The Committee or its delegate may require proof of the death, disability, incompetency, minority, or
incapacity of any Participant or Beneficiary and of the right of a person to receive any benefit or make any application or election. 
 6. Claim Procedures. If a claim under this Deferral Plan is denied by the Committee, the Committee or its delegate shall communicate such denial and shall provide an opportunity to appeal such
denial in a manner which the Committee deems appropriate under the circumstances, which may include following the then applicable claims procedures under the Employee Retirement Income Security Act of 1974, as amended. 

  
 42 

 ARTICLE IX 
 GENERAL AND MISCELLANEOUS PROVISIONS 
 1. No Guarantee of Employment or
Award. Neither this Deferral Plan, a Company Deferral nor a Participant’s Deferral Agreement, either singly or collectively, shall in any way obligate the Company to continue the employment of a Participant with the Company, nor does either
this Deferral Plan, a Company Deferral or a Deferral Agreement limit the right of the Company at any time and for any reason to terminate the Participant’s employment. In no event shall this Deferral Plan, a Company Deferral or a Deferral
Agreement, either singly or collectively, by their terms or implications constitute an employment contract of any nature whatsoever between the Company and a Participant. In no event shall this Deferral Plan, a Company Deferral or a Deferral
Agreement, either singly or collectively, by their terms or implications in any way obligate the Company to award Incentive Compensation, grant any award under the Omnibus Plan or IPA Plan or make any Long Term Incentive Award payment to any
Eligible Employee for any Award Year, whether or not the Eligible Employee is a Participant in the Deferral Plan for that Award Year, nor in any other way limit the right of the Company to change an Eligible Employee’s compensation or other
benefits. 
 2. Affect on Retirement Plans. Neither Incentive Compensation nor Long Term Incentive Award payments
deferred under this Deferral Plan shall be treated as compensation for purposes of calculating the amount of a Participant’s benefits or contributions under any pension, retirement, or other plan maintained by the Company, except as provided in
such other plan. 
 3. Notice. Any written notice to the Company referred to herein shall be made by mailing or
delivering such notice to the Company at 6801 Rockledge Drive, Bethesda, Maryland 20817, to the attention of the Vice President, Human Resources. Any written notice to a Participant shall be made by delivery to the Participant in person, through
electronic transmission, or by mailing such notice to the Participant at his or her last-known place of residence or business address. 
 4. Performance of Acts. In the event it should become impossible for the Company or the Committee to perform any act required by this Deferral Plan, the Company or the Committee may perform such
other act as it in good faith determines will most nearly carry out the intent and the purpose of this Deferral Plan. 
 5.
Employee Consent. By electing to become a Participant hereunder, each Eligible Employee shall be deemed conclusively to have accepted and consented to all of the terms of this Deferral Plan and all actions or decisions made by the Company,
the Board, or Committee with regard to the Deferral Plan. 
 6. Terms Binding. The provisions of this Deferral Plan and
the Deferral Agreements hereunder shall be binding upon and inure to the benefit of the Company, its successors, and its assigns, and to the Participants and their heirs, executors, administrators, and legal representatives. 

  
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 7. Copy of Plan. A copy of this Deferral Plan shall be available for inspection by
Participants or other persons entitled to benefits under the Deferral Plan at reasonable times at the offices of the Company. 

8. State Law. The validity of this Deferral Plan or any of its provisions shall be construed, administered, and governed in all
respects under and by the laws of the State of Maryland, except as to matters of Federal law. If any provisions of this instrument shall be held by a court of competent jurisdiction to be invalid or unenforceable, the remaining provisions hereof
shall continue to be fully effective. 
 9. Regulatory Requirements. This Deferral Plan and its operation, including but
not limited to, the mechanics of deferral elections, the reallocation of all or a portion of a Participant’s Account Balance, the issuance of securities, if any, or the payment of cash hereunder is subject to compliance with all applicable
Federal and state laws, rules and regulations (including but not limited to state and Federal insider trading, registration, reporting and other securities laws) and such other approvals by any listing, regulatory or governmental authority as may,
in the opinion of counsel for the Company, be necessary or advisable in connection therewith. 
 10. Section 16 of
Exchange Act. It is the intent of the Company that this Deferral Plan satisfy and be interpreted in a manner, that, in the case of Participants who are or may be Section 16 Persons, satisfies any applicable requirements of Rule 16b-3 of the
Exchange Act or other exemptive rules under Section 16 of the Exchange Act and will not subject Section 16 Persons to short-swing profit liability thereunder. If any provision of this Deferral Plan would otherwise frustrate or conflict
with the intent expressed in this Section 10, that provision to the extent possible shall be interpreted and deemed amended so as to avoid such conflict. To the extent of any remaining irreconcilable conflict with this intent, the provision
shall be deemed disregarded. Similarly, any action or election by a Section 16 Person with respect to the Deferral Plan to the extent possible shall be interpreted and deemed amended so as to avoid liability under Section 16 or, if this is
not possible, to the extent necessary to avoid liability under Section 16, shall be deemed ineffective. Notwithstanding anything to the contrary in this Deferral Plan, the provisions of this Deferral Plan may at any time be bifurcated by the
Board or the Committee in any manner so that certain provisions of this Deferral Plan are applicable solely to Section 16 Persons. Notwithstanding any other provision of this Deferral Plan to the contrary, if a distribution which would
otherwise occur is prohibited or proposed to be delayed because of the provisions of Section 16 of the Exchange Act or the provisions of the Deferral Plan designed to ensure compliance with Section 16, the Section 16 Person involved
may affirmatively elect in writing to have the distribution occur in any event; provided that the Section 16 Person shall concurrently enter into arrangements satisfactory to the Committee in its sole discretion for the satisfaction of any and
all liabilities, costs and expenses arising from this election. 
 11. Securities Laws. This Deferral Plan, allocations
to and from the Company Stock Investment Option and the issuance and delivery of shares of Common Stock and/or other securities or property or the payment of cash under this Deferral Plan, are subject to compliance with all applicable Federal and
state laws, rules and regulations (including but not limited to state and Federal insider trading, registration, reporting and other securities laws and 

  
 44 

 
Federal margin requirements) and to such approvals by any listing, regulatory or governmental authority as may, in the opinion of counsel for the Company be necessary or advisable to comply with
all legal requirements. Any securities delivered under this Deferral Plan shall be subject to such restrictions (and the person acquiring such securities shall, if requested by the Company provide such evidence, assurance and representations to the
Company as to compliance with any thereof) as counsel to the Company may deem necessary or desirable to assure compliance with all applicable legal requirements. 
 12. 1995 Awards. Notwithstanding any other provision of this Deferral Plan, each Eligible Employee who is a Section 16 Person and has entered into a Deferral Agreement prior to the initial
distribution of a prospectus relating to this Deferral Plan shall be entitled, during a ten-business-day period following the initial distribution of that prospectus, to make an irrevocable election to (i) receive a distribution of all or any
portion of his or her Account Balance attributable to Deferred Compensation for the 1995 Award Year during the seventh month following the month of the election, or (ii) reallocate all or any part of his or her Account Balance attributable to
Deferred Compensation for the 1995 Award Year to a different investment option as of the end of the sixth month following the month of the election. 
 13. Limits on Accounts. At no time shall the aggregate Account Balances of all Participants to the extent allocated to the Company Stock Investment Option exceed an amount equal to the then fair
market value of 5,000,000 shares of the Company’s Common Stock, nor shall the cumulative amount of Incentive Compensation and Long Term Incentive Award payments deferred under this Deferral Plan by all Eligible Employees for all Award Years
exceed $250,000,000. 
 14. Electronic Notice and Signatures. Whenever a signature notice or delivery of a document is
required or appropriate under this Deferral Plan, signature, notice or delivery may be accomplished by paper or written format or, to the extent authorized by the Committee, by electronic means. In the event the Committee authorizes electronic means
for the signature, notice or delivery of a document under this Deferral Plan, the electronic record or confirmation of that signature, notice or delivery maintained by or on behalf of the Committee shall for purposes of this Deferral Plan be treated
as if it was a written signature or notice and was delivered in the manner provided herein for a written document. 
 ARTICLE
X 
 EFFECTIVE DATE AND SHAREHOLDER APPROVAL 
 This Deferral Plan was adopted by the Board on July 27, 1995 and became effective upon adoption to awards of Incentive Compensation for the Company’s fiscal year ending December 31, 1995
and subsequent fiscal years; provided, however, that with respect to Section 16 Persons, the availability of the Company Stock Investment Option is conditioned upon the approval of this Deferral Plan by the stockholders of Lockheed Martin
Corporation. In the event that this Deferral Plan is not approved by the stockholders, then Section 16 Persons shall not be entitled to have Deferred Compensation allocated to the Company Stock Investment Option; any prior elections by
Section 16 Persons to have allocations made to the Company Stock Investment Option shall retroactively be deemed ineffective, and the Account Balances of 

  
 45 

 
those Section 16 Persons shall be restated as if all of their Deferred Compensation had been allocated to the Interest Option at all times. Subsequent amendments to the Deferral Plan are
effective as of the date stated in the amendment or the adopting resolution. 
 This Deferral Plan has been amended and restated
effective as of the date stated on the first page herein. 

  
 46

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