Document:

EX-4.2

 Exhibit 4.2 

PERSONALIS, INC. 

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 

THIS AMENDED AND RESTATED INVESTOR RIGHTS
AGREEMENT (the “Agreement”) is entered into as of the 16th day of December, 2014, by and among PERSONALIS, INC., a Delaware corporation (the
“Company”) and the investors listed on Exhibit A hereto, referred to hereinafter as the “Investors” and each individually as an “Investor.” 

RECITALS 

WHEREAS, certain Investors are purchasing shares of the Company’s Series C Preferred Stock pursuant to that
certain Series C Preferred Stock Purchase Agreement (the “Purchase Agreement”) of even date herewith; (the “Financing”); 

WHEREAS, the obligations in the Purchase Agreement are conditioned upon the execution and
delivery of this Agreement; 
 WHEREAS, certain of the Investors (the “Prior Investors”) are
holders of the Company’s Series A Preferred Stock and Series B Preferred Stock; 

WHEREAS, the Prior Investors and the Company are parties to the Amended and Restated
Investor Rights Agreement dated October 1, 2013 (the “Prior Agreement”); 
 WHEREAS, the
parties to the Prior Agreement desire to amend and restate the Prior Agreement and accept the rights and covenants hereof in lieu of their rights and covenants under the Prior Agreement; and 

WHEREAS, in connection with the consummation of the Financing, the parties desire to enter
into this Agreement in order to grant registration, information rights and other rights to the Investors as set forth below. 

NOW, THEREFORE, in consideration of these premises and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged, the parties hereto agree as follows: 
 SECTION 1. GENERAL. 

1.1 Definitions. As used in this Agreement the following terms shall have the following respective meanings: 

(a) “Exchange Act” means the Securities Exchange Act of 1934, as amended. 

(b) “Form S-3” means such form under the Securities Act as in effect on
the date hereof or any successor or similar registration form under the Securities Act subsequently adopted by the SEC which permits inclusion or incorporation of substantial information by reference to other documents filed by the Company with the
SEC. 

  
 1. 

 (c) “Holder” means any person owning of record Registrable
Securities that have not been sold to the public or any assignee of record of such Registrable Securities in accordance with Section 2.9 hereof. 

(d) “Initial Offering” means the Company’s first firm commitment underwritten public offering of its Common
Stock registered under the Securities Act. 
 (e) “Register,” “registered,” and
“registration” refer to a registration effected by preparing and filing a registration statement in compliance with the Securities Act, and the declaration or ordering of effectiveness of such registration statement or
document. 
 (f) “Registrable Securities” means (a) Common Stock of the Company issuable or issued upon
conversion of the Shares, (b) shares of Common Stock issuable upon exercise of that certain warrant to purchase Common Stock held by Abingworth Bioventures V LP dated as of August 4, 2011, and (c) any Common Stock of the Company
issued as (or issuable upon the conversion or exercise of any warrant, right or other security which is issued as) a dividend or other distribution with respect to, or in exchange for or in replacement of, such above-described securities.
Notwithstanding the foregoing, Registrable Securities shall not include any securities (i) sold by a person to the public either pursuant to a registration statement or Rule 144 or (ii) sold in a private transaction in which the
transferor’s rights under Section 2 of this Agreement are not assigned. 
 (g) “Registrable Securities then
outstanding” shall be the number of shares of the Company’s Common Stock that are Registrable Securities and either (a) are then issued and outstanding or (b) are issuable pursuant to then exercisable or convertible
securities. 
 (h) “Registration Expenses” shall mean all expenses incurred by the Company in complying with
Sections 2.2, 2.3 and 2.4 hereof, including, without limitation, all registration and filing fees, printing expenses, fees and disbursements of counsel for the Company, reasonable fees and disbursements not to exceed seventy-five thousand
dollars ($75,000) of a single special counsel for the Holders, blue sky fees and expenses and the expense of any special audits incident to or required by any such registration (but excluding the compensation of regular employees of the
Company which shall be paid in any event by the Company). 
 (i) “SEC” or “Commission”
means the Securities and Exchange Commission. 
 (j) “Securities Act” shall mean the Securities Act of
1933, as amended. 
 (k) “Selling Expenses” shall mean all underwriting discounts and selling commissions
applicable to the sale. 
 (l) “Series A Preferred Stock” shall mean the Company’s Series A
Preferred Stock, par value $0.0001 per share. 
 (m) “Series B Preferred Stock” shall mean the Company’s
Series B Preferred Stock, par value $0.0001 per share. 

  
 2. 

 (n) “Series C Preferred Stock” shall mean the Company’s
Series C Preferred Stock, par value $0.0001 per share. 
 (o) “Shares” shall mean shares of the Company’s
Series A Preferred Stock, Series B Preferred Stock and Series C Preferred Stock held from time to time by the Investors listed on Exhibit A hereto and their permitted assigns. 

(p) “Special Registration Statement” shall mean (i) a registration statement relating to any employee
benefit plan or (ii) with respect to any corporate reorganization or transaction under Rule 145 of the Securities Act, any registration statements related to the issuance or resale of securities issued in such a transaction or (iii) a
registration related to stock issued upon conversion of debt securities. 
 SECTION 2. REGISTRATION; RESTRICTIONS ON TRANSFER. 

2.1 Restrictions on Transfer. 

(a) Each Holder agrees not to make any disposition of all or any portion of the Shares or Registrable Securities unless and until: 

(i) there is then in effect a registration statement under the Securities Act covering such proposed disposition and such disposition
is made in accordance with such registration statement; or 
 (ii) (A) The transferee has agreed in writing to be bound by the
terms of this Agreement, (B) such Holder shall have notified the Company of the proposed disposition and shall have furnished the Company with a detailed statement of the circumstances surrounding the proposed disposition, and (C) if
reasonably requested by the Company, such Holder shall have furnished the Company with an opinion of counsel, reasonably satisfactory to the Company, that such disposition will not require registration of such shares under the Securities Act. It is
agreed that the Company will not require opinions of counsel for transactions made pursuant to Rule 144, except in unusual circumstances. After its Initial Offering, the Company will not require any transferee pursuant to Rule 144 to be bound by the
terms of this Agreement if the shares so transferred do not remain Registrable Securities hereunder following such transfer. 
 (b)
Notwithstanding the provisions of subsection (a) above, no such restriction shall apply to a transfer by a Holder that is (A) a partnership transferring to its partners or former partners in accordance with partnership interests,
(B) a corporation transferring to a wholly-owned subsidiary or a parent corporation that owns all of the capital stock of the Holder, (C) a limited liability company transferring to its members or former members in accordance with their
interest in the limited liability company, or (D) an individual transferring to the Holder’s family member or trust for the benefit of an individual Holder; provided that in each case the transferee will agree in writing to be
subject to the terms of this Agreement to the same extent as if he were an original Holder hereunder. 
 (c) Each certificate
representing Shares or Registrable Securities shall be stamped or otherwise imprinted with legends substantially similar to the following (in addition to any legend required under applicable state securities laws): 

  
 3. 

 THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933
(THE “ACT”) AND MAY NOT BE OFFERED, SOLD OR OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR HYPOTHECATED UNLESS AND UNTIL REGISTERED UNDER THE ACT OR UNLESS THE COMPANY HAS RECEIVED AN OPINION OF COUNSEL SATISFACTORY TO THE
COMPANY AND ITS COUNSEL THAT SUCH REGISTRATION IS NOT REQUIRED. 
 THE SALE, PLEDGE, HYPOTHECATION OR TRANSFER OF THE SECURITIES REPRESENTED
BY THIS CERTIFICATE IS SUBJECT TO THE TERMS AND CONDITIONS OF A CERTAIN INVESTOR RIGHTS AGREEMENT BY AND BETWEEN THE STOCKHOLDER AND THE COMPANY. COPIES OF SUCH AGREEMENT MAY BE OBTAINED UPON WRITTEN REQUEST TO THE SECRETARY OF THE COMPANY. 

(d) The Company shall be obligated to reissue promptly unlegended certificates at the request of any Holder thereof if the Company has
completed its Initial Offering and the Holder shall have obtained an opinion of counsel (which counsel may be counsel to the Company) reasonably acceptable to the Company to the effect that the securities proposed to be disposed of may lawfully be
so disposed of without registration, qualification and legend, provided that the second legend listed above shall be removed only at such time as the Holder of such certificate is no longer subject to any restrictions hereunder. 

(e) Any legend endorsed on an instrument pursuant to applicable state securities laws and the stop-transfer instructions with respect to
such securities shall be removed upon receipt by the Company of an order of the appropriate blue sky authority authorizing such removal. 

2.2 Demand Registration. 

(a) Subject to the conditions of this Section 2.2, if the Company shall receive a written request from the Holders of a majority of
the Registrable Securities (the “Initiating Holders”) that the Company file a registration statement under the Securities Act covering the registration of at least twenty percent (20%) of the Registrable Securities
then outstanding (with an anticipated aggregate offering price, net of underwriting discounts and commissions, of at least $20,000,000), then the Company shall, within thirty (30) days of the receipt thereof, give written notice of such
request to all Holders, and subject to the limitations of this Section 2.2, effect, as expeditiously as reasonably possible, the registration under the Securities Act of all Registrable Securities that all Holders request to be registered. 

(b) If the Initiating Holders intend to distribute the Registrable Securities covered by their request by means of an underwriting, they
shall so advise the Company as a part of their request made pursuant to this Section 2.2 or any request pursuant to Section 2.4 and the Company shall include such information in the written notice referred to in Section 2.2(a) or

  
 4. 

 
Section 2.4(a), as applicable. In such event, the right of any Holder to include its Registrable Securities in such registration shall be conditioned upon such Holder’s participation in
such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their securities through such underwriting shall enter into an underwriting
agreement in customary form with the underwriter or underwriters selected for such underwriting by the Holders of a majority of the Registrable Securities held by all Initiating Holders (which underwriter or underwriters shall be reasonably
acceptable to the Company). Notwithstanding any other provision of this Section 2.2 or Section 2.4, if the underwriter advises the Company that marketing factors require a limitation of the number of securities to be underwritten
(including Registrable Securities) then the Company shall so advise all Holders of Registrable Securities that would otherwise be underwritten pursuant hereto, and the number of shares that may be included in the underwriting shall be allocated to
the Holders of such Registrable Securities on a pro rata basis based on the number of Registrable Securities held by all such Holders (including the Initiating Holders). Any Registrable Securities excluded or withdrawn from such
underwriting shall be withdrawn from the registration. 
 (c) The Company shall not be required to effect a registration pursuant to
this Section 2.2: 
 (i) prior to the earlier of (A) the third anniversary of the date of this Agreement or (B) of the
expiration of the restrictions on transfer set forth in Section 2.11 following the Initial Offering; 
 (ii) after the Company
has effected two (2) registrations pursuant to this Section 2.2, and such registrations have been declared or ordered effective; 

(iii) during the period starting with the date of filing of, and ending on the date one hundred eighty (180) days following the
effective date of the registration statement pertaining to the Initial Offering (or such longer period as may be determined pursuant to Section 2.11 hereof); provided that the Company makes reasonable good faith efforts to cause such
registration statement to become effective; 
 (iv) if within thirty (30) days of receipt of a written request from Initiating
Holders pursuant to Section 2.2(a), the Company gives notice to the Holders of the Company’s intention to file a registration statement for its Initial Offering within ninety (90) days; 

(v) if the Company shall furnish to Holders requesting a registration statement pursuant to this Section 2.2 a certificate signed
by the Chairman of the Board stating that in the good faith judgment of the Board of Directors of the Company, it would be seriously detrimental to the Company and its stockholders for such registration statement to be effected at such time, in
which event the Company shall have the right to defer such filing for a period of not more than one hundred twenty (120) days after receipt of the request of the Initiating Holders; provided that such right to delay a request shall be
exercised by the Company not more than once in any twelve (12) month period and provided further, that the Company shall not register any securities for the account of itself or any other stockholder during such one hundred twenty
(120) day period (other than a registration relating solely to the sale of securities of participants in a Company stock plan, a registration relating to a corporate reorganization or transaction under Rule

  
 5. 

 
145 of the Securities Act, a registration on any form that does not include substantially the same information as would be required to be included in a registration statement covering the sale of
the Registrable Securities, or a registration in which the only Common Stock being registered is Common Stock issuable upon conversion of debt securities that are also being registered); 

(vi) if the Initiating Holders propose to dispose of shares of Registrable Securities that may be immediately registered on Form S-3 pursuant to a request made pursuant to Section 2.4 below; or 
 (vii) in any
particular jurisdiction in which the Company would be required to qualify to do business or to execute a general consent to service of process in effecting such registration, qualification or compliance. 

2.3 Piggyback Registrations. The Company shall notify all Holders of Registrable Securities in writing at least fifteen
(15) days prior to the filing of any registration statement under the Securities Act for purposes of a public offering of securities of the Company (including, but not limited to, registration statements relating to secondary offerings
of securities of the Company, but excluding Special Registration Statements) and will afford each such Holder an opportunity to include in such registration statement all or part of such Registrable Securities held by such Holder. Each Holder
desiring to include in any such registration statement all or any part of the Registrable Securities held by it shall, within fifteen (15) days after the above-described notice from the Company, so notify the Company in writing. Such notice
shall state the intended method of disposition of the Registrable Securities by such Holder. If a Holder decides not to include all of its Registrable Securities in any registration statement thereafter filed by the Company, such Holder shall
nevertheless continue to have the right to include any Registrable Securities in any subsequent registration statement or registration statements as may be filed by the Company with respect to offerings of its securities, all upon the terms and
conditions set forth herein. 
 (a) Underwriting. If the registration statement of which the Company gives notice under this
Section 2.3 is for an underwritten offering, the Company shall so advise the Holders of Registrable Securities. In such event, the right of any such Holder to include Registrable Securities in a registration pursuant to this Section 2.3
shall be conditioned upon such Holder’s participation in such underwriting and the inclusion of such Holder’s Registrable Securities in the underwriting to the extent provided herein. All Holders proposing to distribute their Registrable
Securities through such underwriting shall enter into an underwriting agreement in customary form with the underwriter or underwriters selected for such underwriting by the Company. Notwithstanding any other provision of this Agreement, if the
Company determines in good faith, based on consultation with the underwriter, that marketing factors require a limitation of the number of shares to be underwritten, the number of shares that may be included in the underwriting shall be allocated,
first, to the Company; second, to the Holders on a pro rata basis based on the total number of Registrable Securities held by the Holders; and third, to any stockholder of the Company (other than a Holder) on a pro rata basis;
provided, however, that no such reduction shall reduce the amount of Registrable Securities of the selling Holders included in the registration below twenty percent (20%) of the total amount of securities included in such registration, unless
such offering is the Initial Offering and such registration does not include shares of any other selling stockholders, in which event any or all of the Registrable Securities of the Holders may be excluded in accordance with the immediately
preceding clause. In no event 

  
 6. 

 
will shares of any other selling stockholder be included in such registration that would reduce the number of shares which may be included by Holders without the written consent of Holders of not
less than: (i) a majority of the Registrable Securities proposed to be sold in the offering, and (ii) the holders of a majority of Preferred Stock, voting as a separate class. If any Holder disapproves of the terms of any such
underwriting, such Holder may elect to withdraw therefrom by written notice to the Company and the underwriter, delivered at least ten (10) business days prior to the effective date of the registration statement. Any Registrable Securities
excluded or withdrawn from such underwriting shall be excluded and withdrawn from the registration. For any Holder which is a partnership, limited liability company or corporation, the partners, retired partners, members, retired members and
stockholders of such Holder, or the estates and family members of any such partners, retired partners, members and retired members and any trusts for the benefit of any of the foregoing person shall be deemed to be a single “Holder,” and
any pro rata reduction with respect to such “Holder” shall be based upon the aggregate amount of shares carrying registration rights owned by all entities and individuals included in such “Holder,” as defined in this
sentence. 
 (b) Right to Terminate Registration. The Company shall have the right to terminate or withdraw any registration initiated
by it under this Section 2.3 whether or not any Holder has elected to include securities in such registration. The Registration Expenses of such withdrawn registration shall be borne by the Company in accordance with Section 2.5 hereof.

 2.4 Form S-3 Registration. In case the Company shall receive from at least twenty
percent (20%) of the Holders of Registrable Securities a written request or requests that the Company effect a registration on Form S-3 (or any successor to Form
S-3) or any similar short-form registration statement and any related qualification or compliance with respect to all or a part of the Registrable Securities owned by such Holders, the Company will: 

(a) promptly give written notice of the proposed registration, and any related qualification or compliance, to all other Holders of
Registrable Securities; and 
 (b) as soon as practicable, effect such registration and all such qualifications and compliances as may
be so requested and as would permit or facilitate the sale and distribution of all or such portion of such Holders’ Registrable Securities as are specified in such request, together with all or such portion of the Registrable Securities of any
other Holder or Holders joining in such request as are specified in a written request given within fifteen (15) days after receipt of such written notice from the Company; provided, however, that the Company shall not be obligated to
effect any such registration, qualification or compliance pursuant to this Section 2.4: 
 (i) if
Form S-3 is not available for such offering by the Holders; 
 (ii) if the Holders,
together with the holders of any other securities of the Company entitled to inclusion in such registration, propose to sell Registrable Securities and such other securities (if any) at an aggregate price to the public of less than one
million dollars ($1,000,000); 

  
 7. 

 (iii) if within thirty (30) days of receipt of a written request from such
Holders pursuant to this Section 2.4, the Company gives notice to such Holders of the Company’s intention to make a public offering within ninety (90) days, other than pursuant to a Special Registration Statement; 

(iv) if the Company shall furnish to the Holders a certificate signed by the Chairman of the Board of Directors of the Company stating
that in the good faith judgment of the Board of Directors of the Company, it would be seriously detrimental to the Company and its stockholders for such Form S-3 registration to be effected at such time,
in which event the Company shall have the right to defer the filing of the Form S-3 registration statement for a period of not more than one hundred twenty (120) days after receipt of the request of
the Holders under this Section 2.4; provided that such right to delay a request shall be exercised by the Company not more than once in any twelve (12) month period and provided further, that the Company shall not register
any securities for the account of itself or any other stockholder during such one hundred twenty (120) day period (other than a registration relating solely to the sale of securities of participants in a Company stock plan, a registration
relating to a corporate reorganization or transaction under Rule 145 of the Securities Act, a registration on any form that does not include substantially the same information as would be required to be included in a registration statement covering
the sale of the Registrable Securities, or a registration in which the only Common Stock being registered is Common Stock issuable upon conversion of debt securities that are also being registered); 

(v) if the Company has, within the twelve (12) month period preceding the date of such request, already effected two
(2) registrations on Form S-3 for the Holders pursuant to this Section 2.4; or 

(vi) in any particular jurisdiction in which the Company would be required to qualify to do business or to execute a general consent to
service of process in effecting such registration, qualification or compliance. 
 (c) Subject to the foregoing, the Company shall
file a Form S-3 registration statement covering the Registrable Securities and other securities so requested to be registered as soon as practicable after receipt of the requests of the Holders.
Registrations effected pursuant to this Section 2.4 shall not be counted as demands for registration or registrations effected pursuant to Section 2.2. 

2.5 Expenses of Registration. Except as specifically provided herein, all Registration Expenses incurred in connection with any
registration, qualification or compliance pursuant to Section 2.2, 2.3 or 2.4 herein shall be borne by the Company. All Selling Expenses incurred in connection with any registrations hereunder, shall be borne by the holders of the securities so
registered pro rata on the basis of the number of shares so registered. The Company shall not, however, be required to pay for expenses of any registration proceeding begun pursuant to Section 2.2 or 2.4, the request of which has been
subsequently withdrawn by the Initiating Holders unless (a) the withdrawal is based upon material adverse information concerning the Company of which the Initiating Holders were not aware at the time of such request or (b) the Holders of a
majority of Registrable Securities agree to deem such registration to have been effected as of the date of such withdrawal for purposes of determining whether the Company shall be obligated 

  
 8. 

 
pursuant to Section 2.2(c) or 2.4(b)(v), as applicable, to undertake any subsequent registration, in which event such right shall be forfeited by all Holders. If the Holders are required to
pay the Registration Expenses, such expenses shall be borne by the holders of securities (including Registrable Securities) requesting such registration in proportion to the number of shares for which registration was requested. If the Company is
required to pay the Registration Expenses of a withdrawn offering pursuant to clause (a) above, then such registration shall not be deemed to have been effected for purposes of determining whether the Company shall be obligated pursuant to
Section 2.2(c) or 2.4(b)(v), as applicable, to undertake any subsequent registration. 
 2.6 Obligations of the Company.
Whenever required to effect the registration of any Registrable Securities, the Company shall, as expeditiously as reasonably possible: 

(a) prepare and file with the SEC a registration statement with respect to such Registrable Securities and use all reasonable efforts to
cause such registration statement to become effective, and, upon the request of the Holders of a majority of the Registrable Securities registered thereunder, keep such registration statement effective for up to thirty (30) days or, if earlier,
until the Holder or Holders have completed the distribution related thereto; provided, however, that at any time, upon written notice to the participating Holders and for a period not to exceed sixty (60) days thereafter (the
“Suspension Period”), the Company may delay the filing or effectiveness of any registration statement or suspend the use or effectiveness of any registration statement (and the Initiating Holders hereby agree not to offer or
sell any Registrable Securities pursuant to such registration statement during the Suspension Period) if the Company reasonably believes that there is or may be in existence material nonpublic information or events involving the Company, the failure
of which to be disclosed in the prospectus included in the registration statement could result in a Violation (as defined below). In the event that the Company shall exercise its right to delay or suspend the filing or effectiveness of a
registration hereunder, the applicable time period during which the registration statement is to remain effective shall be extended by a period of time equal to the duration of the Suspension Period. The Company may extend the Suspension Period for
an additional consecutive sixty (60) days with the consent of the holders of a majority of the Registrable Securities registered under the applicable registration statement, which consent shall not be unreasonably withheld. No more than two
(2) such Suspension Periods shall occur in any twelve (12) month period. If so directed by the Company, all Holders registering shares under such registration statement shall (i) not offer to sell any Registrable Securities
pursuant to the registration statement during the period in which the delay or suspension is in effect after receiving notice of such delay or suspension; and (ii) use their best efforts to deliver to the Company (at the Company’s expense)
all copies, other than permanent file copies then in such Holders’ possession, of the prospectus relating to such Registrable Securities current at the time of receipt of such notice. Notwithstanding the foregoing, the Company shall not be
required to file, cause to become effective or maintain the effectiveness of any registration statement other than a registration statement on Form S-3 that contemplates a distribution of securities on a
delayed or continuous basis pursuant to Rule 415 under the Securities Act. 
 (b) Prepare and file with the SEC such amendments
and supplements to such registration statement and the prospectus used in connection with such registration statement as may be necessary to comply with the provisions of the Securities Act with respect to the disposition of all securities covered
by such registration statement for the period set forth in subsection (a) above. 

  
 9. 

 (c) Furnish to the Holders such number of copies of a prospectus, including a
preliminary prospectus and final prospectus, in conformity with the requirements of the Securities Act, and such other documents as they may reasonably request in order to facilitate the disposition of Registrable Securities owned by them. 

(d) Use its reasonable efforts to register and qualify the securities covered by such registration statement under such other securities
or blue sky laws of such jurisdictions as shall be reasonably requested by the Holders; provided that the Company shall not be required in connection therewith or as a condition thereto to qualify to do business or to file a general consent
to service of process in any such states or jurisdictions. 
 (e) In the event of any underwritten public offering, enter into and
perform its obligations under an underwriting agreement, in usual and customary form, with the managing underwriter(s) of such offering. Each Holder participating in such underwriting shall also enter into and perform its obligations under such an
agreement. 
 (f) Notify each Holder of Registrable Securities covered by such registration statement at any time when a prospectus
relating thereto is required to be delivered under the Securities Act of the happening of any event as a result of which the prospectus included in such registration statement, as then in effect, includes an untrue statement of a material fact or
omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing. The Company will use reasonable efforts to amend or supplement such prospectus
in order to cause such prospectus not to include any untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then
existing. 
 (g) Notify each selling Holder, promptly after the Company receives notice thereof, of the time when such registration
statement has been declared effective or a supplement to any prospectus forming a part of such registration statement has been filed. 

(h) Cause all such Registrable Securities registered hereunder to be listed on each securities exchange on which similar securities
issued by the Company are then listed. 
 (i) Provide a transfer agent and registrar for all Registrable Securities registered
pursuant hereunder and a CUSIP number for all such Registrable Securities, in each case not later than the effective date of such registration. 

(j) Use its reasonable efforts to furnish, on the date that such Registrable Securities are delivered to the underwriters for sale, if
such securities are being sold through underwriters, (i) an opinion, dated as of such date, of the counsel representing the Company for the purposes of such registration, in form and substance as is customarily given to underwriters in an
underwritten public offering, addressed to the underwriters, if any, and (ii) a letter, dated as of such date, from the independent certified public accountants of the Company, in form and substance as is customarily given by independent
certified public accountants to underwriters in an underwritten public offering addressed to the underwriters. 

  
 10. 

 2.7 Delay of Registration; Furnishing Information. 

(a) No Holder shall have any right to obtain or seek an injunction restraining or otherwise delaying any such registration as the result
of any controversy that might arise with respect to the interpretation or implementation of this Section 2. 
 (b) It shall be a
condition precedent to the obligations of the Company to take any action pursuant to Section 2.2, 2.3 or 2.4 that the selling Holders shall furnish to the Company such information regarding themselves, the Registrable Securities held by them
and the intended method of disposition of such securities as shall be required to effect the registration of their Registrable Securities. 

(c) The Company shall have no obligation with respect to any registration requested pursuant to Section 2.2 or Section 2.4 if
the number of shares or the anticipated aggregate offering price of the Registrable Securities to be included in the registration does not equal or exceed the number of shares or the anticipated aggregate offering price required to originally
trigger the Company’s obligation to initiate such registration as specified in Section 2.2 or Section 2.4, whichever is applicable. 

2.8 Indemnification. In the event any Registrable Securities are included in a registration statement under Sections 2.2,
2.3 or 2.4: 
 (a) To the extent permitted by law, the Company will indemnify and hold harmless each Holder, the partners, members,
officers and directors of each Holder, any underwriter (as defined in the Securities Act) for such Holder and each person, if any, who controls such Holder or underwriter within the meaning of the Securities Act or the Exchange Act, against any
losses, claims, damages, or liabilities (joint or several) to which they may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages or liabilities (or actions in respect
thereof) arise out of or are based upon any of the following statements, omissions or violations (collectively a “Violation”) by the Company: (i) any untrue statement or alleged untrue statement of a material fact
contained in such registration statement or incorporated reference therein, including any preliminary prospectus or final prospectus contained therein or any amendments or supplements thereto, (ii) the omission or alleged omission to state
therein a material fact required to be stated therein, or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation by the Company of the Securities Act, the Exchange Act, any state securities law or
any rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities law in connection with the offering covered by such registration statement; and the Company will reimburse each such Holder, partner, member,
officer, director, underwriter or controlling person for any legal or other expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action; provided, however, that the
indemnity agreement contained in this Section 2.8(a) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or action if such settlement is effected without the consent of the Company, which consent shall not
be unreasonably withheld or delayed, nor shall the Company be liable in any such case for any such loss, claim, damage, liability or action to the extent that it arises out of or is based upon a Violation which occurs in reliance upon and in
conformity with written information furnished expressly for use in connection with such registration by such Holder, partner, member, officer, director, underwriter or controlling person of such Holder. 

  
 11. 

 (b) To the extent permitted by law, each Holder will, if Registrable Securities held
by such Holder are included in the securities as to which such registration qualifications or compliance is being effected, indemnify and hold harmless the Company, each of its directors, its officers and each person, if any, who controls the
Company within the meaning of the Securities Act, any underwriter and any other Holder selling securities under such registration statement or any of such other Holder’s partners, directors or officers or any person who controls such Holder,
against any losses, claims, damages or liabilities (joint or several) to which the Company or any such director, officer, controlling person, underwriter or other such Holder, or partner, director, officer or controlling person of such other Holder
may become subject under the Securities Act, the Exchange Act or other federal or state law, insofar as such losses, claims, damages or liabilities (or actions in respect thereto) arise out of or are based upon any of the following statements:
(i) any untrue statement or alleged untrue statement of a material fact contained in such registration statement or incorporated reference therein, including any preliminary prospectus or final prospectus contained therein or any amendments or
supplements thereto, (ii) the omission or alleged omission to state therein a material fact required to be stated therein, or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation by the
Company of the Securities Act (collectively, a “Holder Violation”), in each case to the extent (and only to the extent) that such Holder Violation occurs in reliance upon and in conformity with written information furnished
by such Holder under an instrument duly executed by such Holder and stated to be specifically for use in connection with such registration; and each such Holder will reimburse any legal or other expenses reasonably incurred by the Company or any
such director, officer, controlling person, underwriter or other Holder, or partner, officer, director or controlling person of such other Holder in connection with investigating or defending any such loss, claim, damage, liability or action if it
is judicially determined that there was such a Holder Violation; provided, however, that the indemnity agreement contained in this Section 2.8(b) shall not apply to amounts paid in settlement of any such loss, claim, damage, liability or
action if such settlement is effected without the consent of the Holder, which consent shall not be unreasonably withheld or delayed; provided further, that in no event shall any indemnity under this Section 2.8 exceed the net proceeds
from the offering received by such Holder. 
 (c) Promptly after receipt by an indemnified party under this Section 2.8 of notice
of the commencement of any action (including any governmental action), such indemnified party will, if a claim in respect thereof is to be made against any indemnifying party under this Section 2.8, deliver to the indemnifying party a written
notice of the commencement thereof and the indemnifying party shall have the right to participate in, and, to the extent the indemnifying party so desires, jointly with any other indemnifying party similarly noticed, to assume the defense thereof
with counsel mutually satisfactory to the parties; provided, however, that an indemnified party shall have the right to retain its own counsel, with the fees and expenses thereof to be paid by the indemnifying party, if representation of such
indemnified party by the counsel retained by the indemnifying party would be inappropriate due to actual or potential differing interests between such indemnified party and any other party represented by such counsel in such proceeding. The failure
to deliver written notice to the indemnifying party within a reasonable time of the commencement of any such action shall relieve such indemnifying party of any liability to the indemnified party under this Section 2.8 to the extent, and only
to the extent, prejudicial to its ability to defend such action, but the omission so to deliver written notice to the indemnifying party will not relieve it of any liability that it may have to any indemnified party otherwise than under this
Section 2.8. 

  
 12. 

 (d) If the indemnification provided for in this Section 2.8 is held by a court
of competent jurisdiction to be unavailable to an indemnified party with respect to any losses, claims, damages or liabilities referred to herein, the indemnifying party, in lieu of indemnifying such indemnified party thereunder, shall to the extent
permitted by applicable law contribute to the amount paid or payable by such indemnified party as a result of such loss, claim, damage or liability in such proportion as is appropriate to reflect the relative fault of the indemnifying party on the
one hand and of the indemnified party on the other in connection with the Violation(s) or Holder Violation(s) that resulted in such loss, claim, damage or liability, as well as any other relevant equitable considerations. The relative fault of the
indemnifying party and of the indemnified party shall be determined by a court of law by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission to state a material fact relates to
information supplied by the indemnifying party or by the indemnified party and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission; provided that in no event
shall any contribution by a Holder hereunder exceed the net proceeds from the offering received by such Holder. 
 (e) The obligations
of the Company and Holders under this Section 2.8 shall survive completion of any offering of Registrable Securities in a registration statement and, with respect to liability arising from an offering to which this Section 2.8 would apply
that is covered by a registration filed before termination of this Agreement, such termination. No indemnifying party, in the defense of any such claim or litigation, shall, except with the consent of each indemnified party, consent to entry of any
judgment or enter into any settlement which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such indemnified party of a release from all liability in respect to such claim or litigation. 

2.9 Assignment of Registration Rights. The rights to cause the Company to register Registrable Securities pursuant to this
Section 2 may be assigned by a Holder to a transferee or assignee of Registrable Securities (for so long as such shares remain Registrable Securities) that (a) is a subsidiary, parent, general partner, limited partner, retired partner,
member or retired member, or stockholder of a Holder that is a corporation, partnership or limited liability company, (b) is a Holder’s family member or trust for the benefit of an individual Holder, or (c) acquires at least five
percent (5%) of the then outstanding shares of Registrable Securities (as adjusted for stock splits and combinations); provided, however, (i) the transferor shall, within ten (10) days after such transfer, furnish to the
Company written notice of the name and address of such transferee or assignee and the securities with respect to which such registration rights are being assigned and (ii) such transferee shall agree to be subject to all restrictions set forth
in this Agreement. 
 2.10 Limitation on Subsequent Registration Rights. Other than as provided in Section 5.10, after the
date of this Agreement, the Company shall not enter into any agreement with any holder or prospective holder of any securities of the Company that would grant such holder rights to demand the registration of shares of the Company’s capital
stock, or to include such shares in a registration statement that would reduce the number of shares includable by the Holders. 

  
 13. 

 2.11 “Market
Stand-Off” Agreement. Each Holder hereby agrees that such Holder shall not sell, transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or
similar transaction with the same economic effect as a sale, any Common Stock (or other securities) of the Company held by such Holder (other than those included in the registration) (i) during the
180-day period following the effective date of the Initial Offering (or such longer period, not to exceed 34 days after the expiration of the 180-day period, as the
underwriters or the Company shall request in order to facilitate compliance with NASD Rule 2711 or NYSE Member Rule 472 or any successor or similar rule or regulation), and (ii) the 90-day period
following the effective date of a registration statement of the Company filed under the Securities Act (or such longer period, not to exceed 34 days after the expiration of the 90-day period, as the
underwriters or the Company shall request in order to facilitate compliance with NASD Rule 2711 or NYSE Member Rule 472 or any successor or similar rule or regulation); provided, that, with respect to (i) and (ii) above, all officers and
directors of the Company and holders of at least one percent (1%) of the Company’s voting securities are bound by and have entered into similar agreements. The obligations described in this Section 2.11 shall not apply to a registration
relating solely to employee benefit plans on Form S-1 or Form S-8 or similar forms that may be promulgated in the future, or a registration relating solely to a
transaction on Form S-4 or similar forms that may be promulgated in the future. 
 2.12
Agreement to Furnish Information. Each Holder agrees to execute and deliver such other agreements as may be reasonably requested by the Company or the underwriter that are consistent with the Holder’s obligations under
Section 2.11 or that are necessary to give further effect thereto. In addition, if requested by the Company or the representative of the underwriters of Common Stock (or other securities) of the Company, each Holder shall provide, within ten
(10) days of such request, such information as may be required by the Company or such representative in connection with the completion of any public offering of the Company’s securities pursuant to a registration statement filed under the
Securities Act. The obligations described in Section 2.11 and this Section 2.12 shall not apply to a Special Registration Statement. The Company may impose stop-transfer instructions with respect to the shares of Common Stock (or other
securities) subject to the foregoing restriction until the end of said day period. Each Holder agrees that any transferee of any shares of Registrable Securities shall be bound by Sections 2.11 and 2.12. The underwriters of the Company’s
stock are intended third party beneficiaries of Sections 2.11 and 2.12 and shall have the right, power and authority to enforce the provisions hereof as though they were a party hereto. 

2.13 Rule 144 Reporting. With a view to making available to the Holders the benefits of certain rules and regulations of the SEC
which may permit the sale of the Registrable Securities to the public without registration, the Company agrees to use its best efforts to: 

(a) Make and keep public information available, as those terms are understood and defined in SEC Rule 144 or any similar or
analogous rule promulgated under the Securities Act, at all times after the effective date of the first registration filed by the Company for an offering of its securities to the general public; 

  
 14. 

 (b) take such action, including voluntary registration of its Common Stock under
Section 12 of the Exchange Act, as is necessary to enable the Holders to utilize Form S-3 for the sale of their Registrable Securities; 

(c) File with the SEC, in a timely manner, all reports and other documents required of the Company under the Securities Act and the
Exchange Act; and 
 (d) So long as a Holder owns any Registrable Securities, furnish to such Holder forthwith upon request: a written
statement by the Company as to its compliance with the reporting requirements of said Rule 144 of the Securities Act, and of the Exchange Act (at any time after it has become subject to such reporting requirements); a copy of the most recent annual
or quarterly report of the Company filed with the Commission; and such other reports and documents as a Holder may reasonably request in connection with availing itself of any rule or regulation of the SEC allowing it to sell any such securities
without registration. 
 2.14 Termination of Registration Rights. The right of any Holder to request registration or inclusion
of Registrable Securities in any registration pursuant to Section 2.2, Section 2.3, or Section 2.4 hereof shall terminate upon the earlier of: (i) the date three (3) years following a Qualified Public Offering (as
defined in the Amended and Restated Certificate of Incorporation of the Company, of even date herewith (the “Amended Charter”)) that results in the conversion of all outstanding shares of Preferred stock; (ii) such time
as such Holder holds less than one percent (1%) of the Company’s outstanding Common Stock (treating all shares of Preferred Stock on an as converted basis), the Company has completed its Initial Offering and all Registrable Securities of the
Company issuable or issued upon conversion of the Shares held by and issuable to such Holder (and its affiliates) may be sold pursuant to Rule 144 during any ninety (90) day period, or (iii) after consummation of a Liquidation Event (as
defined in the Amended Charter). Upon such termination, such shares shall cease to be “Registrable Securities” hereunder for all purposes. 

SECTION 3. COVENANTS OF THE COMPANY. 

3.1 Basic Financial Information and Reporting. 

(a) The Company will maintain true books and records of account in which full and correct entries will be made of all its business
transactions pursuant to a system of accounting established and administered in accordance with generally accepted accounting principles consistently applied (except as noted therein or as disclosed to the recipients thereof), and will set aside on
its books all such proper accruals and reserves as shall be required under generally accepted accounting principles consistently applied. 

(b) To the extent requested by a Major Investor (as defined below), as soon as practicable after the end of each fiscal year of the
Company, and in any event within one hundred twenty (120) days thereafter, the Company will furnish such Major Investor a balance sheet of the Company, as at the end of such fiscal year, and a statement of income and a statement of cash
flows of the Company, for such year, all prepared in accordance with generally accepted accounting principles consistently applied (except as noted therein or as disclosed to the recipients thereof) and setting forth in each case in comparative form
the figures for the previous fiscal year, all in reasonable detail. Such financial statements shall be accompanied by a report and opinion thereon by independent public accountants of national standing selected by the Company’s Board of
Directors. 

  
 15. 

 (c) To the extent requested by a Major Investor (as defined below), the Company will
furnish such Major Investor, as soon as practicable after the end of each quarterly accounting period in each fiscal year of the Company, and in any event within forty-five (45) days thereafter, a balance sheet of the Company as of the
end of each such quarterly period, and a statement of income and a statement of cash flows of the Company for such period and for the current fiscal year to date, prepared in accordance with generally accepted accounting principles
consistently applied (except as noted therein or as disclosed to the recipients thereof), with the exception that no notes need be attached to such statements and year-end audit adjustments may not have been
made. 
 (d) So long as an Investor (with its affiliates) shall own not less than five percent (5%) of the Preferred Stock of the
Company (as adjusted for stock splits and combinations) (a “Major Investor”), the Company will furnish each such Major Investor: (i) at least thirty (30) days prior to the beginning of each fiscal year an annual
budget and operating plans for such fiscal year (and as soon as available, any subsequent written revisions thereto); and (ii) as soon as practicable after the end of each month, and in any event within twenty (20) days thereafter, a
balance sheet of the Company as of the end of each such month, and a statement of income and a statement of cash flows of the Company for such month and for the current fiscal year to date, including a comparison to plan figures for such period,
prepared in accordance with generally accepted accounting principles consistently applied (except as noted thereon), with the exception that no notes need be attached to such statements and year-end audit
adjustments may not have been made. 
 If, for any period, the Company has any subsidiary whose accounts are consolidated with those of the Company, then in
respect of such period the financial statements delivered pursuant to the foregoing sections shall be the consolidated and consolidating financial statements of the Company and all such consolidated subsidiaries. 

3.2 Inspection Rights. Each Major Investor shall have the right to visit and inspect any of the properties of the Company or any
of its subsidiaries, and to discuss the affairs, finances and accounts of the Company or any of its subsidiaries with its officers, and to review such information as is reasonably requested all at such reasonable times and as often as may be
reasonably requested; provided, however, that the Company shall not be obligated under this Section 3.2 with respect to a competitor of the Company or with respect to information which the Board of Directors determines in good faith is
confidential or attorney-client privileged and should not, therefore, be disclosed. 
 3.3 Confidentiality of Records. Each
Investor agrees to use the same degree of care as such Investor uses to protect its own confidential information to keep confidential any information furnished to such Investor pursuant to Section 3.1 and 3.2 hereof that the Company identifies
as being confidential or proprietary (so long as such information is not in the public domain), except that such Investor may disclose such proprietary or confidential information (i) to any partner, subsidiary or parent of such Investor as
long as such partner, subsidiary or parent is 

  
 16. 

 
advised of and agrees or has agreed to be bound by the confidentiality provisions of this Section 3.3 or comparable restrictions; (ii) at such time as it enters the public domain
through no fault of such Investor; (iii) that is communicated to it free of any obligation of confidentiality; (iv) that is developed by Investor or its agents independently of and without reference to any confidential information
communicated by the Company; (v) as required by applicable law or (vi) to any legal counsel or accountants of an Investor as long as such legal counsel or accountant is advised of and agrees to be bound by the confidentiality provisions of
this Section 3.3 or comparable restrictions. 
 3.4 Reservation of Common Stock. The Company will at all times reserve and
keep available, solely for issuance and delivery upon the conversion of the Preferred Stock, all Common Stock issuable from time to time upon such conversion. 

3.5 Stock Vesting. Unless otherwise approved by the Board of Directors, all stock options and other stock equivalents issued
after the date of this Agreement to employees, directors, consultants and other service providers shall be subject to vesting as follows: (a) twenty-five percent (25%) of such stock shall vest at the end of the first year following the earlier
of the date of issuance or such person’s services commencement date with the Company, and (b) seventy-five percent (75%) of such stock shall vest over the remaining three (3) years. Unless otherwise approved by the Board of Directors,
if an employee is terminated or resigns from the Company for any reason, all unvested options will expire immediately, and the employee will have ninety (90) days to exercise all vested options, after which time, all unexercised vested options
will expire. 
 3.6 Protective Provision. So long as at least 1,000,000 shares of Preferred Stock remain outstanding (as
adjusted for stock splits and combinations), in the aggregate, the Company will not, without approval of the Board of Directors, do any of the following: (i) make any capital expenditures (including expenditures under capitalized leases) that
are more than ten (10%) in excess of the annual budget approved by the Board of Directors, (ii) incur any indebtedness of more than $1,000,000 in the aggregate, (iii) agree to any sale, transfer, disposition, or license of any intellectual
property rights of the Company or other Company assets, except in the ordinary course of business; (iv) use any Company assets for the redemption, retirement, purchase or acquisition, directly or indirectly, of any of the Company’s stock,
options or convertible debt, (v) enter into or be a party to any transaction with any director, officer or employee of the Company, except transactions made in the ordinary course of business and pursuant to reasonable requirements of the
Company’s business and upon fair and reasonable terms; or (vi) change the principal business of the Company, enter new lines of business, or exit the current line of business. 

3.7 Director and Officer Insurance. The Company will use its best efforts to maintain (unless otherwise approved by the
Company’s Board of Directors) in full force and effect director and officer liability insurance in the amount as determined by a majority of the Company’s Board of Directors. 

3.8 Proprietary Information and Inventions Agreement. The Company shall require all employees to execute and deliver a
proprietary information and inventions agreement substantially in a form approved by the Company’s counsel or Board of Directors and shall obtain from all consultants a proprietary information and inventions assignment. 

  
 17. 

 3.9 Directors’ Liability and Indemnification. The Amended
Charter and Bylaws shall provide (a) for elimination of the liability of director to the maximum extent permitted by law and (b) for indemnification of directors for acts on behalf of the Company to the maximum extent permitted by law. In
addition, the Company shall enter into and use its best efforts to at all times maintain indemnification agreements, substantially in a form approved by the Company’s counsel or Board of Directors, with each of its directors to indemnify such
directors to the maximum extent permissible under applicable law. 
 3.10 Qualified Small Business. The Company will use
reasonable efforts to comply with the reporting and recordkeeping requirements of Section 1202 of the Internal Revenue Code of 1986, as amended (the “Code”), any regulations promulgated thereunder and any
similar state laws and regulations, and agrees not to repurchase any stock of the Company if such repurchase would cause the Shares not to so qualify as “Qualified Small Business Stock,” so long as the Company’s Board of Directors
determines that it is in the best interests of and not unduly burdensome to the Company to comply with the provisions of Section 1202 of the Code. 

3.11 Termination of Covenants. All covenants of the Company contained in Section 3 of this Agreement (other than the
provisions of Sections 3.3 and 3.7) shall expire and terminate as to each Investor upon the earlier of (i) the effective date of the registration statement pertaining to an Initial Offering or (ii) upon an
“Acquisition” (as defined in the Amended Charter). 
 3.12 Director’s Expenses. The Company shall reimburse non-employee directors for all reasonable travel and other expenses incurred in attending meetings of the Board of Directors. 

SECTION 4. RIGHTS OF FIRST REFUSAL. 

4.1 Subsequent Offerings. Subject to applicable securities laws, each Major Investor shall have a right of first refusal to
purchase its pro rata share of all Equity Securities, as defined below, that the Company may, from time to time, propose to sell and issue after the date of this Agreement, other than the Equity Securities excluded by Section 4.6 hereof.
Each Investor’s pro rata share is equal to the ratio of (a) the number of shares of the Company’s Common Stock (including all shares of Common Stock issuable or issued upon conversion of the Shares or upon the exercise of
outstanding warrants or options) of which such Investor is deemed to be a holder immediately prior to the issuance of such Equity Securities to (b) the total number of shares of the Company’s outstanding Common Stock (including all shares
of Common Stock issued or issuable upon conversion of the Shares or upon the exercise of any outstanding warrants or options) immediately prior to the issuance of the Equity Securities. The term “Equity Securities” shall mean
(i) any Common Stock, Preferred Stock or other security of the Company, (ii) any security convertible into or exercisable or exchangeable for, with or without consideration, any Common Stock, Preferred Stock or other security (including
any option to purchase such a convertible security), (iii) any security carrying any warrant or right to subscribe to or purchase any Common Stock, Preferred Stock or other security or (iv) any such warrant or right. 

4.2 Exercise of Rights. If the Company proposes to issue any Equity Securities, it shall give each Major Investor written
notice of its intention, describing the Equity Securities, the price and the terms and conditions upon which the Company proposes to issue the same. Each Major Investor shall have fifteen (15) days from the giving of such notice to agree
to purchase up 

  
 18. 

 
to its pro rata share of the Equity Securities for the price and upon the terms and conditions specified in the notice by giving written notice to the Company and stating therein the
quantity of Equity Securities to be purchased. Notwithstanding the foregoing, the Company shall not be required to offer or sell such Equity Securities to any Major Investor who would cause the Company to be in violation of applicable federal
securities laws by virtue of such offer or sale. 
 4.3 Issuance of Equity Securities to Other Persons. If not all of the Major
Investors elect to purchase their entire pro rata share of the Equity Securities, then the Company shall promptly notify in writing the Major Investors who do so elect (each, a “Fully Exercising Investor”) and
shall offer each such Fully Exercising Investor the right to acquire such unsubscribed shares on a pro rata basis. Each Fully Exercising Investor shall have five (5) days after receipt of such notice to notify the Company of its
election to purchase all or a portion thereof of the unsubscribed shares. The Company shall have ninety (90) days thereafter to sell the Equity Securities in respect of which the Major Investor’s or Fully Exercising Investors rights
were not exercised, at a price not lower and upon general terms and conditions not materially more favorable to the purchasers thereof than specified in the Company’s notice to the Major Investors pursuant to Section 4.2 hereof. If the
Company has not sold such Equity Securities within ninety (90) days of the notice provided pursuant to Section 4.2, the Company shall not thereafter issue or sell any Equity Securities, without first reoffering such securities to the
Major Investors in the manner provided above. 
 4.4 Termination and Waiver of Rights of First Refusal. The rights of
first refusal established by this Section 4 shall not apply to, and shall terminate upon the earlier of (i) the effective date of the registration statement pertaining to the Company’s Initial Offering or (ii) an Acquisition.
Notwithstanding Section 5.5 hereof, the rights of first refusal established by this Section 4 may be amended, or any provision waived with and only with the written consent of the Company and the Major Investors holding a majority
of the Registrable Securities held by all Major Investors, or as permitted by Section 5.5. 
 4.5 Assignment of Rights of
First Refusal. The rights of first refusal of each Major Investor under this Section 4 may be assigned to the same parties, subject to the same restrictions as any transfer of registration rights pursuant to Section 2.9. 

4.6 Excluded Securities. The rights of first refusal established by this Section 4 shall have no application to any of the
following Equity Securities: 
 (a) shares of Common Stock and/or options, warrants or other Common Stock purchase rights and the
Common Stock issued pursuant to such options, warrants or other rights (as adjusted for any stock dividends, combinations, splits, recapitalizations and the like after the date hereof) issued or to be issued after the date hereof to employees,
officers or directors of, or consultants or advisors to the Company or any subsidiary, pursuant to stock purchase or stock option plans or other arrangements that are approved by the Board of Directors; 

(b) stock issued or issuable pursuant to any rights or agreements, options, warrants or convertible securities outstanding as of the
date of this Agreement; and stock issued pursuant to any such rights or agreements granted after the date of this Agreement, so long as the rights of first refusal established by this Section 4 were complied with, waived, or were inapplicable
pursuant to any provision of this Section 4.6 with respect to the initial sale or grant by the Company of such rights or agreements; 

  
 19. 

 (c) any Equity Securities issued for consideration other than cash pursuant to a
merger, consolidation, acquisition or similar business combination; 
 (d) any Equity Securities issued in connection with any stock
split, stock dividend or recapitalization by the Company; 
 (e) any Equity Securities issued pursuant to any equipment loan or
leasing arrangement, real property leasing arrangement, or debt financing from a bank or similar financial or lending institution; 
 (f)
any Equity Securities that are issued by the Company pursuant to a registration statement filed under the Securities Act; 
 (g)
any Equity Securities issued in connection with strategic transactions involving the Company and other entities, including, without limitation (i) joint ventures, manufacturing, marketing or distribution arrangements or (ii) technology
transfer or development arrangements; and 
 (h) any Equity Securities issued by the Company pursuant to the terms of Section 2.2
of the Purchase Agreement. 
 SECTION 5. MISCELLANEOUS. 

5.1 Governing Law. This Agreement shall be governed by and construed under the laws of the State of California in all
respects as such laws are applied to agreements among California residents entered into and to be performed entirely within California, without reference to conflicts of laws or principles thereof. The parties agree that any action brought by either
party under or in relation to this Agreement, including without limitation to interpret or enforce any provision of this Agreement, shall be brought in, and each party agrees to and does hereby submit to the jurisdiction and venue of, any state or
federal court located in the County of Santa Clara, California. 
 5.2 Successors and Assigns. Except as otherwise expressly
provided herein, the provisions hereof shall inure to the benefit of, and be binding upon, the parties hereto and their respective successors, assigns, heirs, executors, and administrators and shall inure to the benefit of and be enforceable by each
person who shall be a holder of Registrable Securities from time to time; provided, however, that prior to the receipt by the Company of adequate written notice of the transfer of any Registrable Securities specifying the full name and
address of the transferee, the Company may deem and treat the person listed as the holder of such shares in its records as the absolute owner and holder of such shares for all purposes, including the payment of dividends or any redemption price.

  
 20. 

 5.3 Entire Agreement. This Agreement, the exhibits and schedule hereto, the
Purchase Agreement and the other documents delivered pursuant thereto constitute the full and entire understanding and agreement between the parties with regard to the subjects hereof and no party shall be liable or bound to any other in any manner
by any oral or written representations, warranties, covenants and agreements except as specifically set forth herein and therein. Each party expressly represents and warrants that it is not relying on any oral or written representations, warranties,
covenants or agreements outside of this Agreement. 
 5.4 Severability. In the event one or more of the provisions of this
Agreement should, for any reason, be held to be invalid, illegal or unenforceable in any respect, such invalidity, illegality, or unenforceability shall not affect any other provisions of this Agreement, and this Agreement shall be construed as if
such invalid, illegal or unenforceable provision had never been contained herein. 
 5.5 Amendment and Waiver. 

(a) Except as otherwise expressly provided, this Agreement may be amended or modified, and the obligations of the Company and the rights
of the Holders under this Agreement may be waived, only upon the written consent of the Company and the holders of a majority of the then-outstanding Registrable Securities. 

(b) For the purposes of determining the number of Holders or Investors entitled to vote or exercise any rights hereunder, the Company
shall be entitled to rely solely on the list of record holders of its stock as maintained by or on behalf of the Company. 
 5.6
Delays or Omissions. It is agreed that no delay or omission to exercise any right, power, or remedy accruing to any party, upon any breach, default or noncompliance by another party under this Agreement shall impair any such right, power,
or remedy, nor shall it be construed to be a waiver of any such breach, default or noncompliance, or any acquiescence therein, or of any similar breach, default or noncompliance thereafter occurring. It is further agreed that any waiver, permit,
consent, or approval of any kind or character on any party’s part of any breach, default or noncompliance under the Agreement or any waiver on such party’s part of any provisions or conditions of this Agreement must be in writing and shall
be effective only to the extent specifically set forth in such writing. All remedies, either under this Agreement, by law, or otherwise afforded to any party, shall be cumulative and not alternative. 

5.7 Notices. All notices required or permitted hereunder shall be in writing and shall be deemed effectively given: (a) upon
personal delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the recipient; if not, then on the next business day, (c) five (5) days after having been
sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one (1) day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. All
communications shall be sent to the party to be notified at the address as set forth on the signature pages hereof or Exhibit A hereto or at such other address or electronic mail address as such party may designate by ten (10) days advance
written notice to the other parties hereto. 
 5.8 Attorneys’ Fees. In the event that any suit or action is
instituted under or in relation to this Agreement, including without limitation to enforce any provision in this Agreement, the prevailing party in such dispute shall be entitled to recover from the losing party all fees, costs and expenses of
enforcing any right of such prevailing party under or with respect to this Agreement, including without limitation, such reasonable fees and expenses of attorneys and accountants, which shall include, without limitation, all fees, costs and expenses
of appeals. 

  
 21. 

 5.9 Titles and Subtitles. The titles of the sections and subsections of this
Agreement are for convenience of reference only and are not to be considered in construing this Agreement. 
 5.10 Additional
Investors. Notwithstanding anything to the contrary contained herein, if the Company shall issue additional shares of its Preferred Stock pursuant to the Purchase Agreement, any purchaser of such shares of Preferred Stock shall become a party to
this Agreement by executing and delivering an additional counterpart signature page to this Agreement and shall be deemed an “Investor,” a “Holder” and a party hereunder. Notwithstanding anything to the contrary contained herein,
if the Company shall issue Equity Securities in accordance with Section 4.6 (c), (e) or (h) of this Agreement, any purchaser of such Equity Securities may become a party to this Agreement by executing and delivering an additional
counterpart signature page to this Agreement and shall be deemed an “Investor,” a “Holder” and a party hereunder. 

5.11 Counterparts. This Agreement may be executed in any number of counterparts, each of which shall be an original, but all of
which together shall constitute one instrument. 
 5.12 Aggregation of Stock. All shares of Registrable Securities held or
acquired by affiliated entities or persons or persons or entities under common management or control shall be aggregated together for the purpose of determining the availability of any rights under this Agreement. 

5.13 Pronouns. All pronouns contained herein, and any variations thereof, shall be deemed to refer to the masculine, feminine or
neutral, singular or plural, as to the identity of the parties hereto may require. 
 5.14 Termination. This Agreement shall
terminate and be of no further force or effect upon the earlier of (i) an Acquisition of the Company; or (ii) the date three (3) years following the closing of the Initial Offering. 

[THIS SPACE INTENTIONALLY LEFT BLANK] 

  
 22. 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

	
	COMPANY:
	
	PERSONALIS, INC.
	
	 /s/ John West

	John West
	President and Chief Executive Officer

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

			
	INVESTOR:
	
	LIGHTSPEED VENTURE PARTNERS VIII, L.P.
		
	By:	 	Lightspeed General Partner VIII, L.P.,
		 	its general partner
		
	By:	 	 Lightspeed Ultimate General Partner VIII,

Ltd., its general partner

 
			
		
	By:	 	 /s/ Christopher Schaepe

	Name:	 	Christopher Schaepe
	Title:	 	Duly authorized signatory
		
	Address:	 	2200 Sand Hill
		 	Menlo Park, CA 94025

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

			
	INVESTOR:
	
	 LIGHTSPEED VENTURE PARTNERS SELECT,

L.P.

		
	By:	 	Lightspeed General Partner Select, L.P.,
		 	its general partner
		
	By:	 	 Lightspeed Ultimate General Partner
 Select,
Ltd., its general partner

 
			
		
	By:	 	 /s/ Christopher Schaepe

	Name:	 	Christopher Schaepe
	Title:	 	Duly authorized signatory
		
	Address:	 	2200 Sand Hill
		 	Menlo Park, CA 94025

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

			
	INVESTOR:
	
	ABINGWORTH BIOVENTURES V LP
	Acting by its manager Abingworth LLP
		
	By:	 	 /s/ [illegible]

	Name:	 	[illegible]
	Title:	 	Partner

  

			
	Address:	 	 c/o Abingworth LLP
 38 Jermyn St.

London SW1Y/6DN
 United Kingdom

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.  

 

			
	INVESTOR:
	
	MDV IX, L.P., as nominee for
	MDV IX, L.P., and MDV ENF IX, L.P
		
	By:	 	 /s/ Brett Teele

	Name:	 	Brett Teele
	Title:	 	CFO & Authorized Signatory

 
			
		
	Address:	 	 3000 Sand Hill Road
 Bldg 3., Ste 290

Menlo Park, CA 94025

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

			
	INVESTOR:
	
	 THE BOARD OF TRUSTEES OF THE
LELAND
 STANFORD JUNIOR UNIVERSITY
(PVF)

 
			
		
	By:	 	 /s/ Martina S. Poquet

	Name:	 	Martina S. Poquet
	Title:	 	Managing Director - Separate Investments
		
	Address:	 	Direct Investments
		 	 Stanford Management Company
 635 Knight
Way
 Stanford, California 94305-7297

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

			
	INVESTOR:
	
	 THE BOARD OF TRUSTEES OF THE
LELAND
 STANFORD JUNIOR UNIVERSITY (DAPER I)

	
	 THE BOARD OF TRUSTEES OF THE
LELAND
 STANFORD JUNIOR UNIVERSITY
(SBST)

 
			
		
	By:	 	 /s/ Martina S. Poquet

	Name:	 	Martina S. Poquet
	Title:	 	 Managing Director - Separate Investments 

		
	Address:	 	Stanford Management Company
		 	 635 Knight Way
 Stanford, CA 94305-7297

Attn: Direct Investments

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

			
	 INVESTOR:
  

GC&H INVESTMENTS, LLC

 
			
		
	 By:
	 	 /s/ Jim Kindler

	 Name:
	 	Jim Kindler
	 Title:
	 	Manager
		
	 Address:
	 	101 California Street, 5th Floor
		 	San Francisco, CA 94111

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

			
	INVESTOR:
	
	 Charles E Murphy III & Reva Murphy Jt

Rev Tr CE Murphy III TTEE Et Al

 
			
		
	By:	 	 /s/ Charles E. Murphy III

	Name:	 	Charles E. Murphy III

 
			
	Title (if applicable):	 	Trustee

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.  

 

			
	INVESTOR: 
	
	 K.C. & Diane Murphy Family Trust

K.C.H. Murphy TTEE Et Al u/a dtd 6/2/09

		
	By:	 	 /s/ Kenneth C. H. Murphy    /s/ Diane Murphy

	Name:	 	 Kenneth C. H. Murphy
 Diane
Murphy

 
			
	Title (if applicable):	 	Trustees

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.  

 

			
	INVESTOR: 
	
	 US Trust
 Derek Lagemann
Generations Tr u/a dtd
 8/6/98, Carter S. Bacon Jr. Trustee

		
	By:	 	 /s/ Carter Bacon

	Name:	 	Carter Bacon

 
			
	Title (if applicable):	 	Trustee

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

  

			
	INVESTOR: 
	
	 US Trust
 Derek Lagemann
2000 Irrev Tr u/a dtd
 3/29/2000, Carter S. Bacon Jr. & Peter

J. Lagemann, TTEES

		
	By:	 	 /s/ Carter Bacon

	Name:	 	Carter Bacon

 
			
	Title (if applicable):	 	Trustee

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the
parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

			
	INVESTOR: 
	
	 US Trust
 Derek Lagemann
2000 Irrev Tr u/a dtd
 3/29/2000, Carter S. Bacon Jr. & Peter

J. Lagemann, TTEES

		
	By:	 	 /s/ Peter J. Lagemann

	Name:	 	Peter J. Lagemann

 
			
	Title (if applicable):	 	Trustee

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

			
	INVESTOR: 
	
	 Beatrice E. Dunn

		
	By:	 	 /s/ Beatrice E. Dunn

	Name:	 	Beatrice E. Dunn

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof.  

 

			
	INVESTOR: 
	
	 Peter J. Lagemann

		
	By:	 	 /s/ Peter J. Lagemann

	Name:	 	Peter J. Lagemann

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of date set forth in the first paragraph hereof. 

 

			
	INVESTOR: 
	
	 US Trust FBO Peter J. Lagemann, Carter S. Bacon Jr. & Laurence A. Shadek, Trustees

		
	By:	 	 /s/ Carter Bacon

	Name:	 	Carter Bacon

 
			
	Title (if applicable):	 	Trustee

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth in the first paragraph hereof. 

 

			
	INVESTOR: 
	
	 US Trust FBO Peter J. Lagemann, Carter S. Bacon Jr. & Laurence A. Shadek, Trustees

		
	By:	 	 /s/ Laurence A. Shadek

	Name:	 	Laurence A. Shadek

 
			
	Title (if applicable):	 	Trustee

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 Mark P. Sperry

		
	By:	 	 /s/ Mark P. Sperry

	Name:	 	Mark P. Sperry

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 Corydon S. Sperry Jr. MD

		
	By:	 	 /s/ Corydon S. Sperry Jr. MD

	Name:	 	Corydon S. Sperry Jr. MD

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 Cassandra Ordway

		
	By:	 	 /s/ Cassandra S. Ordway

	Name:	 	Cassandra S. Ordway

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 Duck Pond Partners

		
	By:	 	 /s/ Laurence A. Shadek

	Name:	 	Laurence A. Shadek

 
			
	Title (if applicable):	 	President of the General Partner

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 Peter Waltman & Noami Waltman Jt.

		
	By:	 	 /s/ Peter Waltman & Noami Waltman

	Name:	 	Peter & Noami Waltman

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 The THW Group, L.P.

		
	By:	 	 /s/ Peter Waltman

	Name:	 	Peter Waltman

 
			
	Title (if applicable):	 	 Managing Partner

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 O.B. Joyful Dynasty Tr

Joy Stillman & Shirley Els Ttees
 u/a dtd
08/05/2008

		
	By:	 	 /s/ Joy Stillman

	Name:	 	Joy Stillman

 
			
	Title (if applicable):	 	 Trustee

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 Trieber Ventures LLC

		
	By:	 	 /s/ Edward Trieber

	Name:	 	Edward Trieber

 
			
	Title (if applicable):	 	 Managing Member

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 Pamela G. Upson

		
	By:	 	 /s/ Pamela G. Upson

	Name:	 	Pamela G. Upson

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 James Upson

		
	By:	 	 /s/ James M. Upson

	Name:	 	James M. Upson

 
			
	Title (if applicable):	 	 n/a

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 Derek W. Upson

		
	By:	 	 /s/ Derek Upson

	Name:	 	Derek Upson

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 Candace Bignell & Christopher Bignell Jt Ten

		
	By:	 	 /s/ Candace U. Bignell & Christopher S. Bignell

	Name:	 	Candace U. Bignell & Christopher S. Bignell

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 William J. Korntheuer

		
	By:	 	 /s/ William J. Korntheuer

	Name:	 	William J. Korntheuer

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 Charles R. McDermott

		
	By:	 	 /s/ Charles R. McDermott

	Name:	 	Charles R. McDermott

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of the date set forth
in the first paragraph hereof. 
  

			
	INVESTOR: 
	
	 Philip Ordway

		
	By:	 	 /s/ Philip W. Ordway

	Name:	 	Philip W. Ordway

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of December 24, 2014.

  

			
	INVESTOR: 
	
	 American Estate & Trust IRA

FBO Marion T. Boyer

		
	By:	 	 /s/ Marion T. Boyer

	Name:	 	Marion T. Boyer

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of December 24, 2014.

  

			
	INVESTOR: 
	
	 American Estate & Trust IRA

FBO Michael A. Jones

		
	By:	 	 /s/ Michael A. Jones

	Name:	 	Michael A. Jones

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of December 24, 2014.

  

			
	INVESTOR: 
	
	 Benjamin Burditt

Individual Retirement Plan
 RBC Capital Markets LLC
Cust

		
	By:	 	 /s/ Benjamin A. Burditt

	Name:	 	Benjamin A. Burditt

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of December 26, 2014.

  

			
	INVESTOR: 
	
	 American Estate & Trust IRA

FBO Lorraine J. Prentis

		
	By:	 	 /s/ Lorraine J. Prentis

	Name:	 	Lorraine J. Prentis

 
			
	Title (if applicable):	 	  

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of January 12, 2015.

  

			
	INVESTOR:
	
	 FREDERICK J. DOTZLER AND CASSANDRA L. DOTZLER
TRUSTEES OF THE DOTZLER FAMILY TRUST UDT, DATED AUGUST 9, 2001

		
	By:	 	 /s/ Frederick J. Dotzler

	Name:	 	Frederick J. Dotzler
	Title:	 	Trustee
		
	Address:	 	19438 Burgundy Way
		 	Saratoga, CA 95070

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS
WHEREOF, the parties hereto have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of January 7, 2015.

  

			
	INVESTORS:
	
	TITUS TRADING CORPORATION
		
	By:	 	 /s/ Stella Mitchell-Voisin    /s/ P.J. Welch

	Name:	 	Stella Mitchell-Voisin     Philippa Welch
	Title:	 	For Ruby Directors Limited and Emerald Directors Limited, Directors, Titus Trading Corporation

  
 Signature Page to

 Personalis, Inc. Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of January 7, 2015. 

 

			
	INVESTORS:
	
	ST. CHRISTOPHER CORPORATION
		
	By:	 	 /s/ Stella Mitchell-Voisin    /s/ P.J. Welch

	Name:	 	Stella Mitchell-Voisin     Philippa Welch
	Title:	 	For Ruby Directors Limited and Emerald Directors Limited, Directors, St. Christopher Corporation

  
 Signature Page to

 Personalis, Inc. Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of January 12, 2015. 

 

			
	INVESTORS:
	
	 ARD CORPORATION

		
	By:	 	 /s/ Susie Taylor & Nadine Morin

	Name:	 	 Susie Taylor & Nadine Morin

	Title:	 	 Authorised Signatures

  
 Signature Page to

 Personalis, Inc. Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of January 12, 2015. 

 

			
	INVESTOR:
	
	 Signed as a deed by PROVIDENCE INVESTMENT COMPANY LIMITED
acting by a director and its secretary or two directors

		
	By:	 	 /s/ [illegible]

	Name:	 	 IAN CUMING [illegible]

	Title:	 	 Director

		
	Address:	 	La Motte Chambers
		 	 St. Helier, Jersey
 JEI IPB, Channel Islands

Attention: Ian Cuming, Director of Providence

  
 Signature Page to

 Personalis, Inc. Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of 12 January, 2015. 

 

			
	INVESTORS:
	
	 RONA MARIA JONES DECLARATION OF
TRUST DATED 06/03/1992, ANTHONY A. JONES, TRUSTEE

		
	By:	 	 /s/ Anthony A. Jones

	Name:	 	 Anthony A. Jones

	Title:	 	 Trustee

  
 Signature Page to

 Personalis, Inc. Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of Jan. 5, 2015. 

 

			
	INVESTORS:
	
	 JULIEN N. VACHON

		
	By:	 	 /s/ Julien N. Vachon

	Name:	 	 Julien N. Vachon

	Title:	 	  

	
	NATIONAL FINANCIAL SERVICES FBO JULIEN N. VACHON IRA
		
	By:	 	 /s/ Julien N. Vachon

	Name:	 	Julien N. Vachon
	Title:	 	  

  
 Signature Page to

 Personalis, Inc. Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of 1/7, 2015. 

 

			
	INVESTORS:
	
	 AMERICAN ESTATE & TRUST IRA FBO

FREDERICK M. SEIFERT

		
	By:	 	 /s/ Frederick M. Seifert

	Name:	 	 Frederick M. Seifert

	Title:	 	  

  
 Signature Page to

 Personalis, Inc. Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of 1/30, 2015. 

 

			
	 PURCHASER:

	
	 THE BOARD OF TRUSTEES OF THE
LELAND
 STANFORD JUNIOR UNIVERSITY (DAPER1)

		
	By:	 	 /s/ Martina Poquet

	Name:	 	 Martina Poquet

	Title:	 	 Managing Director, Separate Investments

		
	Address:	 	Direct Investments
		 	 Stanford Management Company
 635 Knight Way

Stanford, California 94305-7297

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 IN WITNESS WHEREOF, the parties hereto
have executed this AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT as of 1/30, 2015. 

 

			
	 PURCHASER:

	
	 THE BOARD OF TRUSTEES OF THE
LELAND
 STANFORD JUNIOR UNIVERSITY (SBST)

		
	By:	 	 /s/ Martina Poquet

	Name:	 	 Martina Poquet

	Title:	 	 Managing Director, Separate Investments

		
	Address:	 	Direct Investments
		 	 Stanford Management Company
 635 Knight Way

Stanford, California 94305-7297

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights Agreement 

 EXHIBIT A 

SCHEDULE OF INVESTORS 
 Series A
Investors 
 Abingworth Bioventures V LP 
 MDV IX, L.P. 

MDV ENF IX, L.P. 
 Lightspeed Venture Partners VIII, L.P. 

Frederick J. Dotzler and Cassandra L. Dotzler, Trustees of the Dotzler Family Trust UDT Dated August 9, 2001 

GC&H Investments, LLC 
 Providence Investment Company Limited

 The Board of Trustees of the Leland Stanford Junior University (DAPER I) 

The Board of Trustees of the Leland Stanford Junior University (SBST) 

The Board of Trustees of the Leland Stanford Junior University (PVF) 

Series B Investors 
 Abingworth Bioventures V LP 

MDV IX, L.P. 
 MDV ENF IX, L.P. 

Lightspeed Venture Partners VIII, L.P. 
 Frederick J. Dotzler and
Cassandra L. Dotzler, Trustees of the Dotzler Family Trust UDT Dated August 9, 2001 
 GC&H Investments, LLC 

Providence Investment Company Limited 
 The Board of Trustees of
the Leland Stanford Junior University (DAPER I) 
 The Board of Trustees of the Leland Stanford Junior University (SBST) 

The Board of Trustees of the Leland Stanford Junior University (PVF) 

Charles E Murphy III & Reva Murphy Jt 
 Rev Tr CE Murphy
III TTEE Et Al 
 K.C. & Diane Murphy Family Trust 
 K.C.H.
Murphy TTEE Et Al u/a dtd 6/2/09 
 US Trust 
 Derek Lagemann
Generations Tr u/a dtd 
 8/6/98, Carter S. Bacon Jr. Trustee 

US Trust 
 Derek Lagemann 2000 Irrev Tr u/a dtd 

3/29/2000, Carter S. Bacon Jr. & Peter 
 J. Lagemann, TTEES

 Julien N. Vachon 

  
 Exhibit to 

Personalis, Inc. Amended and Restated Investor Rights Agreement 

 National Financial Services 

FBO Julien N. Vachon IRA 
 Beatrice E. Dunn 

Peter J. Lagemann 
 Peter E.G. Bruckmann 

James W.B. Bruckmann 
 David P.K. Bruckmann 

William M. Barnum 
 Mark P. Sperry 

Corydon S. Sperry Jr. MD 
 Cassandra Ordway 

Duck Pond Partners 
 Peter Waltman & Naomi Waltman Jt.

 The THW Group, L.P. 
 American Estate & Trust IRA

 FBO Marion T. Boyer 
 Rona Maria Jones Declaration of Trust
dated 06/03/1992, Anthony A. Jones, Trustee 
 American Estate & Trust IRA 

FBO Michael A. Jones 
 Lorraine Prentis 

American Estate & Trust IRA 
 FBO Frederick M. Seifert

 O.B. Joyful Dynasty Tr 
 Joy Stillman & Shirley Els
Ttees 
 u/a dtd 08/05/2008 
 Trieber Ventures LLC 

Pamela G. Upson 
 Series C Investors 

Lightspeed Venture Partners Select, L.P. 
 Lightspeed Venture
Partners VIII, L.P. 
 Abingworth Bioventures V LP 
 MDV IX,
L.P. 
 MDV ENF IX LP 
 The Board of Trustees of the Leland
Stanford Junior University (PVF) 
 GC&H Investments, LLC 
  

  
 Exhibit to 

Personalis, Inc. Amended and Restated Investor Rights Agreement 

 Charles E. Murphy III & Reva Murphy Jt Rev Tr 

CE Murphy III TTEE Et Al 
 K.C. & Diane Murphy Family Trust
K.C.H. 
 Murphy TTEE Et Al u/a dtd 6/2/09 
 US Trust Derek
Lagemann Generations Tr u/a 
 dtd 8/6/98, Carter S. Bacon Jr. Trustee 

US Trust Derek Lagemann 2000 Irrev Tr u/a 
 dtd 3/29/2000, Carter
S. Bacon Jr. & Peter J. Lagemann, TTEES 
 Beatrice E. Dunn 

Peter J. Lagemann 
 US Trust FBO Peter J. Lagemann, 

Carter S. Bacon Jr. & Laurence a. Shadek Trustees 
 Mark P.
Sperry 
 Corydon S. Sperry Jr. M.D. 
 Cassandra Ordway 

Duck Pond Partners, L.P. 
 Peter Waltman & Naomi Waltman
Jt. 
 The THW Group, L.P. 
 O.B. Joyful Dynasty Tr Joy
Stillman & Shirley 
 Els Ttees u/a dtd 08/05/2008 

Trieber Ventures LLC 
 Pamela G. Upson 

James Upson 
 Derek W. Upson 

Candace Bignell & Christopher Bignell Jt. Ten 
 William
J Korntheuer 
 Charles R. McDermott 
 Philip Ordway 

American Estate & Trust IRA FBO Marion T. Boyer 

American Estate & Trust IRA FBO Michael A. Jones 

Benjamin Burditt Individual Retirement Plan 
 RBC Capital Markets
LLC Cust 

  
 Exhibit to 

Personalis, Inc. Amended and Restated Investor Rights Agreement 

 American Estate & Trust IRA FBO Lorraine J. Prentis 

Abingworth Bioventures V LP 
 Titus Trading Corporation 

St. Christopher Corporation 
 ARD Corporation 

Frederick J. Dotzler and Cassandra L. Dotzler, 
 Trustees of the
Dotzler Family Trust UDT dated August 9, 2001 
 Providence Investment Company Limited 

Julien N. Vachon 
 Rona Maria Jones Declaration of Trust 

dated 06/03/1992, Anthony A. Jones, Trustee 
 National Financial
Services FBO Julien N. Vachon IRA 
 American Estate & Trust IRA FBO Frederick M. Seifert 

The Board of Trustees of the Leland Stanford Junior University (SBST) 

The Board of Trustees of the Leland Stanford Junior University (PVF) 

Rona Maria Jones Declaration of Trust 
 dated 06/03/1992, Anthony
A. Jones, Trustee 
 Charles Vachon & Virginia Vachon Jt Ten 

Derek Lagemann Trust f/b/o Carter S. Bacon, Jr. 
 Derek Lagemann
Trust f/b/o Children of Peter Lagemann 
 Derek Lagemann Trust f/b/o Robin Greenwood 

Dorothy S Lagemann 
 Edward W. Seifert & Anita A. Seifert

 Eric K Bacon 
 GST Trust U/W Martha S. Bacon, Hoyt W. Bacon,
Trustee 
 Henry Miller 
 Hoyt W Bacon 

Mark H Scott-Paine 
 Mats Andersson & Kristina Andersson
Jt Ten 

  
 Exhibit to 

Personalis, Inc. Amended and Restated Investor Rights Agreement 

 Michael Scrivens 

Pamela G. Upson Trust, Pamela G. Upson & Gilbert M. Upson TTEES, u/a dtd 09/12/1996 

PENSCO Trust Company LLC, Custodian for Bruce Oberfest & Associates Profit Sharing/401k Plan FBO Bruce Oberfest, Custodian Only 

PENSCO Trust Company LLC, Custodian for Bruce Oberfest & Associates Profit Sharing/401k Plan FBO Gail Oberfest, Custodian Only 

Philip W. Ordway, Trustee of the Philip W. Ordway Trust Created by Agreement dated September 13, 2016 

Proship Limited Retirement Tr 
 Ramana Lagemann 

Richard E. Gentilli & Jane C. Gentilli Jt Ten 

  
 Signature Page to

 Personalis, Inc. Amended and Restated Investor Rights AgreementEX-4.3

 Exhibit 4.3 

THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR
THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN SECTIONS 5.3 AND 5.4 BELOW, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR IN FORM AND SUBSTANCE SATISFACTORY TO THE
COMPANY, SUCH OFFER, SALE, PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION. 
 WARRANT TO PURCHASE STOCK 

Company: PERSONALIS, INC. 
 Number of Shares:
89,956 
 Type/Series of Stock: Series B Preferred Stock 

Warrant Price: $1.15 per share 
 Issue Date:
September 25, 2014 
 Expiration Date: September 25, 2024 See also Section 5.1(b). 

			
	Credit Facility:	  	This Warrant to Purchase Stock (“Warrant”) is issued in connection with that certain Loan and Security Agreement of even date herewith between Silicon Valley Bank and the Company (the “Loan
Agreement”).

 THIS WARRANT CERTIFIES THAT, for good and valuable consideration, SILICON VALLEY BANK (together with any
successor or permitted assignee or transferee of this Warrant or of any shares issued upon exercise hereof, “Holder”) is entitled to purchase the number of fully paid and non-assessable shares (the
“Shares”) of the above-stated Type/Series of Stock (the “Class”) of the above-named company (the “Company”) at the above-stated Warrant Price, all as set forth above and as
adjusted pursuant to Section 2 of this Warrant, subject to the provisions and upon the terms and conditions set forth in this Warrant. Reference is made to Section 5.4 of this Warrant whereby Silicon Valley Bank shall transfer this Warrant
to its parent company, SVB Financial Group. 
 SECTION 1. EXERCISE. 

1.1 Method of Exercise. Holder may at any time and from time to time through the Expiration Date exercise this Warrant, in whole or in
part, by delivering to the Company the original of this Warrant together with a duly executed Notice of Exercise in substantially the form attached hereto as Appendix 1 and, unless Holder is exercising this Warrant pursuant to a cashless exercise
set forth in Section 1.2, a check, wire transfer of same-day funds (to an account designated by the Company), or other form of payment acceptable to the Company for the aggregate Warrant Price for the Shares being purchased. 

1.2 Cashless Exercise. On any exercise of this Warrant, in lieu of payment of the aggregate Warrant Price in the manner as specified in
Section 1.1 above, but otherwise in accordance with the requirements of Section 1.1, Holder may elect to receive Shares equal to the value of this Warrant, or portion hereof as to which this Warrant is being exercised as set forth in the
following sentence. Thereupon, the Company shall issue to Holder such number of fully paid and non-assessable Shares as are computed using the following formula: 

X = Y(A-B)/A 

  
 1 

 where: 
  

			
	 X =
	  	the number of Shares to be issued to Holder;
		
	 Y =
	  	the number of Shares with respect to which this Warrant is being exercised (inclusive of the Shares surrendered to the Company in payment of the aggregate Warrant Price);
		
	 A =
	  	the Fair Market Value (as determined pursuant to Section 1.3 below) of one Share; and
		
	 B =
	  	the Warrant Price.

 1.3 Fair Market Value. If the Company’s common stock is then traded or quoted on a nationally
recognized securities exchange, inter-dealer quotation system or over-the-counter market (a “Trading Market”) and the Class is common stock, the fair market value of a Share shall be the closing price or last sale price of a
share of common stock reported for the Business Day immediately before the date on which Holder delivers this Warrant together with its Notice of Exercise to the Company. If the Company’s common stock is then traded in a Trading Market and the
Class is a series of the Company’s convertible preferred stock, the fair market value of a Share shall be the closing price or last sale price of a share of the Company’s common stock reported for the Business Day immediately before the
date on which Holder delivers this Warrant together with its Notice of Exercise to the Company multiplied by the number of shares of the Company’s common stock into which a Share is then convertible. If the Company’s common stock is not
traded in a Trading Market, the Board of Directors of the Company shall determine the fair market value of a Share in its reasonable good faith judgment; provided, however, that if this Warrant is exercised in connection with the Company’s IPO
(as defined below), the fair market value of one Share shall be the per share offering price to the public of the Company’s initial public offering. 

1.4 Delivery of Certificate and New Warrant. Within a reasonable time after Holder exercises this Warrant in the manner set forth in
Section 1.1 or 1.2 above, the Company shall deliver to Holder a certificate representing the Shares issued to Holder upon such exercise and, if this Warrant has not been fully exercised and has not expired, a new warrant of like tenor
representing the Shares not so acquired. 
 1.5 Replacement of Warrant. On receipt of evidence reasonably satisfactory to the Company
of the loss, theft, destruction or mutilation of this Warrant and, in the case of loss, theft or destruction, on delivery of an indemnity agreement reasonably satisfactory in form, substance and amount to the Company or, in the case of mutilation,
on surrender of this Warrant to the Company for cancellation, the Company shall, within a reasonable time, execute and deliver to Holder, in lieu of this Warrant, a new warrant of like tenor and amount. 

1.6 Treatment of Warrant Upon Acquisition of Company. 

(a) Acquisition. For the purpose of this Warrant, “Acquisition” means any transaction or series of related
transactions involving: (i) the sale, lease, exclusive license, or other disposition of all or substantially all of the assets of the Company (ii) any merger or consolidation of the Company into or with another person or entity (other than
a merger or consolidation effected exclusively to change the Company’s domicile), or any other corporate reorganization, in which the stockholders of the Company in their capacity as such immediately prior to such merger, consolidation or
reorganization, own less than a majority of the Company’s (or the surviving or successor entity’s) 

  
 2 

 
outstanding voting power immediately after such merger, consolidation or reorganization; or (iii) any sale or other transfer by the stockholders of the Company of shares representing at
least a majority of the Company’s then-total outstanding combined voting power. For the avoidance of doubt, “Acquisition” shall exclude any transaction in which the Company sells and issues its capital stock to venture capital
investors for capital raising purposes in a bona fide round of preferred stock financing. 
 (b) Treatment of Warrant at Acquisition.
In the event of an Acquisition in which the consideration to be received by the Company’s stockholders consists solely of cash, solely of Marketable Securities or a combination of cash and Marketable Securities (a “Cash/Public
Acquisition”), and the fair market value of one Share as determined in accordance with Section 1.3 above would be greater than the Warrant Price in effect on such date immediately prior to such Cash/Public Acquisition, and Holder
has not exercised this Warrant pursuant to Section 1.1 above as to all Shares, then this Warrant shall automatically be deemed to be Cashless Exercised pursuant to Section 1.2 above as to all Shares effective immediately prior to and
contingent upon the consummation of a Cash/Public Acquisition. In connection with such Cashless Exercise, Holder shall be deemed to have restated each of the representations and warranties in Section 4 of the Warrant as the date thereof and the
Company shall promptly notify Holder of the number of Shares (or such other securities) issued upon exercise. In the event of a Cash/Public Acquisition where the fair market value of one Share as determined in accordance with Section 1.3 above
would be less than the Warrant Price in effect immediately prior to such Cash/Public Acquisition, then this Warrant will expire immediately prior to the consummation of such Cash/Public Acquisition and shall no longer be exercisable. 

(c) Upon the closing of any Acquisition other than a Cash/Public Acquisition defined above, the acquiring, surviving or successor entity shall
assume the obligations of this Warrant, and this Warrant shall thereafter be exercisable for the same securities and/or other property as would have been paid for the Shares issuable upon exercise of the unexercised portion of this Warrant as if
such Shares were outstanding on and as of the closing of such Acquisition, subject to further adjustment from time to time in accordance with the provisions of this Warrant. 

(d) As used in this Warrant, “Marketable Securities” means securities meeting all of the following requirements,
determined as of immediately prior to the closing of an Acquisition: (i) the issuer thereof is then subject to the reporting requirements of Section 13 or Section 15(d) of the Securities Exchange Act of 1934, as amended (the
“Exchange Act”), and is then current in its filing of all required reports and other information under the Act and the Exchange Act; (ii) the class and series of shares or other security of the issuer that would be
received by Holder in connection with the Acquisition were Holder to exercise this Warrant on or prior to the closing thereof is then traded in Trading Market, and (iii) following the closing of such Acquisition, Holder would not be restricted
from publicly re-selling all of the issuer’s shares and/or other securities that would be received by Holder in such Acquisition were Holder to exercise or convert this Warrant in full on or prior to the closing of such Acquisition, except to
the extent that any such restriction (x) arises solely under federal or state securities laws, rules or regulations, and (y) does not extend beyond six (6) months from the closing of such Acquisition. 

SECTION 2. ADJUSTMENTS TO THE SHARES AND WARRANT PRICE. 

2.1 Stock Dividends, Splits, Etc. If the Company declares or pays a dividend or distribution on the outstanding shares of the Class
payable in common stock or other securities or property (other than cash), then upon exercise of this Warrant, for each Share acquired, Holder shall receive, without additional cost to Holder, the total number and kind of securities and property
which 

  
 3 

 
Holder would have received had Holder owned the Shares of record as of the date the dividend or distribution occurred. If the Company subdivides the outstanding shares of the Class by
reclassification or otherwise into a greater number of shares, the number of Shares purchasable hereunder shall be proportionately increased and the Warrant Price shall be proportionately decreased. If the outstanding shares of the Class are
combined or consolidated, by reclassification or otherwise, into a lesser number of shares, the Warrant Price shall be proportionately increased and the number of Shares shall be proportionately decreased. 

2.2 Reclassification, Exchange, Combinations or Substitution. Upon any event whereby all of the outstanding shares of the Class are
reclassified, exchanged, combined, substituted, or replaced for, into, with or by Company securities of a different class and/or series, then from and after the consummation of such event, this Warrant will be exercisable for the number, class and
series of Company securities that Holder would have received had the Shares been outstanding on and as of the consummation of such event, and subject to further adjustment thereafter from time to time in accordance with the provisions of this
Warrant. The provisions of this Section 2.2 shall similarly apply to successive reclassifications, exchanges, combinations substitutions, replacements or other similar events. 

2.3 Conversion of Preferred Stock. If the Class is a class and series of the Company’s convertible preferred stock, in the event
that all outstanding shares of the Class are converted, automatically or by action of the holders thereof, into common stock pursuant to the provisions of the Company’s Certificate of Incorporation, including, without limitation, in connection
with the Company’s initial, underwritten public offering and sale of its common stock pursuant to an effective registration statement under the Act (the “IPO”), then from and after the date on which all outstanding
shares of the Class have been so converted, this Warrant shall be exercisable for such number of shares of common stock into which the Shares would have been converted had the Shares been outstanding on the date of such conversion, and the Warrant
Price shall equal the Warrant Price in effect as of immediately prior to such conversion divided by the number of shares of common stock into which one Share would have been converted, all subject to further adjustment thereafter from time to time
in accordance with the provisions of this Warrant. 
 2.4 Adjustments for Diluting Issuances. Without duplication of any adjustment
otherwise provided for in this Section 2, the number of shares of common stock issuable upon conversion of the Shares shall be subject to anti-dilution adjustment from time to time in the manner set forth in the Company’s Certificate of
Incorporation as if the Shares were issued and outstanding on and as of the date of any such required adjustment. 
 2.5 No Fractional
Share. No fractional Share shall be issuable upon exercise of this Warrant and the number of Shares to be issued shall be rounded down to the nearest whole Share. If a fractional Share interest arises upon any exercise of the Warrant, the
Company shall eliminate such fractional Share interest by paying Holder in cash the amount computed by multiplying the fractional interest by (i) the fair market value (as determined in accordance with Section 1.3 above) of a full Share,
less (ii) the then-effective Warrant Price. 
 2.6 Notice/Certificate as to Adjustments. Upon each adjustment of the Warrant
Price, Class and/or number of Shares, the Company, at the Company’s expense, shall notify Holder in writing within a reasonable time setting forth the adjustments to the Warrant Price, Class and/or number of Shares and facts upon which such
adjustment is based. The Company shall, upon written request from Holder, furnish Holder with a certificate of its Chief Financial Officer, including computations of such adjustment and the Warrant Price, Class and number of Shares in effect upon
the date of such adjustment. 

  
 4 

 SECTION 3. REPRESENTATIONS AND COVENANTS OF THE COMPANY. 

3.1 Representations and Warranties. The Company represents and warrants to, and agrees with, Holder as follows: 

(a) As of the Issue Date, the initial Warrant Price referenced on the first page of this Warrant is not greater than the price per share at
which shares of the Class were last sold and issued prior to the Issue Date hereof in an arms-length transaction in which at least $500,000 of such shares were sold. 

(b) All Shares which may be issued upon the exercise of this Warrant, and all securities, if any, issuable upon conversion of the Shares,
shall, upon issuance, be duly authorized, validly issued, fully paid and non-assessable, and free of any liens and encumbrances except for restrictions on transfer provided for herein, under the Company’s Certificate of Incorporation, Bylaws,
as amended from time to time, and Investor Rights Agreement, as amended from time to time (the “Investor Rights Agreement”), or under applicable federal and state securities laws. The Company covenants that it shall at all
times cause to be reserved and kept available out of its authorized and unissued capital stock such number of shares of the Class, common stock and other securities as will be sufficient to permit the exercise in full of this Warrant and the
conversion of the Shares into common stock or such other securities. 
 (c) The Company’s capitalization table attached hereto as
Schedule 1 is true and complete, in all material respects, as of the Issue Date. 
 3.2 Notice of Certain Events. If the Company
proposes at any time to: 
 (a) declare any dividend or distribution upon the outstanding shares of the Class or common stock, whether in
cash, property, stock, or other securities and whether or not a regular cash dividend; 
 (b) offer for subscription or sale pro rata to the
holders of the outstanding shares of the Class any additional shares of any class or series of the Company’s stock (other than pursuant to contractual pre-emptive rights); 

(c) effect any reclassification, exchange, combination, substitution, reorganization or recapitalization of the outstanding shares of the
Class; 
 (d) effect an Acquisition or to liquidate, dissolve or wind up; or 

(e) effect an IPO; 
 then, in connection with
each such event, the Company shall give Holder: 
 (1) at least seven (7) Business Days prior written notice of the date
on which a record will be taken for such dividend, distribution, or subscription rights (and specifying the date on which the holders of outstanding shares of the Class will be entitled thereto) or for determining rights to vote, if any, in respect
of the matters referred to in (a) and (b) above; 

  
 5 

 (2) in the case of the matters referred to in (c) and (d) above at
least seven (7) Business Days prior written notice of the date when the same will take place (and specifying the date on which the holders of outstanding shares of the Class will be entitled to exchange their shares for the securities or other
property deliverable upon the occurrence of such event and such reasonable information as Holder may reasonably require regarding the treatment of this Warrant in connection with such event giving rise to the notice); and 

(3) with respect to the IPO, at least seven (7) Business Days prior written notice of the date on which the Company
proposes to file its registration statement in connection therewith. 
 Company will also provide information requested by Holder that is reasonably
necessary to enable Holder to comply with Holder’s accounting or reporting requirements. 
 SECTION 4. REPRESENTATIONS, WARRANTIES OF
HOLDER. 
 Holder represents and warrants to the Company as follows: 

4.1 Purchase for Own Account. This Warrant and the securities to be acquired upon exercise of this Warrant by Holder are being acquired
for investment for Holder’s account, not as a nominee or agent, and not with a view to the public resale or distribution within the meaning of the Act. Holder also represents that it has not been formed for the specific purpose of acquiring
this Warrant or the Shares. 
 4.2 Disclosure of Information. Holder is aware of the Company’s business affairs and financial
condition and has received or has had full access to all the information it considers necessary or appropriate to make an informed investment decision with respect to the acquisition of this Warrant and its underlying securities. Holder further has
had an opportunity to ask questions and receive answers from the Company regarding the terms and conditions of the offering of this Warrant and its underlying securities and to obtain additional information (to the extent the Company possessed such
information or could acquire it without unreasonable effort or expense) necessary to verify any information furnished to Holder or to which Holder has access. 

4.3 Investment Experience. Holder understands that the purchase of this Warrant and its underlying securities involves substantial risk.
Holder has experience as an investor in securities of companies in the development stage and acknowledges that Holder can bear the economic risk of such Holder’s investment in this Warrant and its underlying securities and has such knowledge
and experience in financial or business matters that Holder is capable of evaluating the merits and risks of its investment in this Warrant and its underlying securities and/or has a preexisting personal or business relationship with the Company and
certain of its officers, directors or controlling persons of a nature and duration that enables Holder to be aware of the character, business acumen and financial circumstances of such persons. 

4.4 Accredited Investor Status. Holder is an “accredited investor” within the meaning of Regulation D promulgated under the
Act. 

  
 6 

 4.5 The Act. Holder understands that this Warrant and the Shares issuable upon
exercise hereof have not been registered under the Act in reliance upon a specific exemption therefrom, which exemption depends upon, among other things, the bona fide nature of Holder’s investment intent as expressed herein. Holder understands
that this Warrant and the Shares issued upon any exercise hereof must be held indefinitely unless subsequently registered under the Act and qualified under applicable state securities laws, or unless exemption from such registration and
qualification are otherwise available. Holder is aware of the provisions of Rule 144 promulgated under the Act. 
 4.6 Market Stand-off
Agreement. Holder agrees that the Shares shall be subject to the Market Standoff provisions in Section 2.11 of the Investor Rights Agreement or similar agreement. 

4.7 No Voting Rights; No Stockholder Rights. Holder, as a Holder of this Warrant, will not have any voting rights or otherwise be
entitled to any other rights afforded to a stockholder of the Company until the exercise of this Warrant. 
 SECTION 5. MISCELLANEOUS. 

5.1 Term and Automatic Conversion Upon Expiration. 

(a) Term. Subject to the provisions of Section 1.6 above, this Warrant is exercisable in whole or in part at any time and from time
to time on or before 6:00 PM, Pacific time, on the Expiration Date and shall be void thereafter. 
 (b) Automatic Cashless Exercise upon
Expiration. In the event that, upon the Expiration Date, the fair market value of one Share (or other security issuable upon the exercise hereof) as determined in accordance with Section 1.3 above is greater than the Warrant Price in effect
on such date, then this Warrant shall automatically be deemed on and as of such date to be exercised pursuant to Section 1.2 above as to all Shares (or such other securities) for which it shall not previously have been exercised, and the
Company shall, within a reasonable time, deliver a certificate representing the Shares (or such other securities) issued upon such exercise to Holder. 

5.2 Legends. The Shares (and the securities issuable, directly or indirectly, upon conversion of the Shares, if any) shall be imprinted
with a legend in substantially the following form (as well as any other legends required by the Company’s Certificate of Incorporation, Bylaws, each as amended from time to time, and the Investor Rights Agreement, as applicable): 

(a) Securities Law Legend: 

THE SHARES EVIDENCED BY THIS CERTIFICATE HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE
“ACT”), OR THE SECURITIES LAWS OF ANY STATE AND, EXCEPT AS SET FORTH IN THAT CERTAIN WARRANT TO PURCHASE STOCK ISSUED BY THE ISSUER TO SILICON VALLEY BANK DATED
SEPTEMBER        , 2014, MAY NOT BE OFFERED, SOLD, PLEDGED OR OTHERWISE TRANSFERRED UNLESS AND UNTIL REGISTERED UNDER SAID ACT AND LAWS OR IN FORM AND SUBSTANCE SATISFACTORY TO THE ISSUER, SUCH OFFER, SALE,
PLEDGE OR OTHER TRANSFER IS EXEMPT FROM SUCH REGISTRATION. 

  
 7 

 (b) Market Stand-Off Legend: 

THE SHARES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO RESTRICTIONS ON TRANSFERABILITY AND RESALE, INCLUDING A LOCK-UP PERIOD IN THE EVENT
OF AN INITIAL PUBLIC OFFERING, AS SET FORTH IN THAT CERTAIN WARRANT TO PURCHASE STOCK ISSUED BY THE ISSUER TO SILICON VALLEY BANK DATED SEPTEMBER 25, 2014, PURSUANT TO WHICH THESE SHARES WERE ISSUED. 

5.3 Compliance with Securities Laws on Transfer. This Warrant and the Shares issuable upon exercise of this Warrant (and the securities
issuable, directly or indirectly, upon conversion of the Shares, if any) may not be transferred or assigned in whole or in part except in compliance with applicable federal and state securities laws by the transferor and the transferee (including,
without limitation, the delivery of investment representation letters and legal opinions reasonably satisfactory to the Company, as reasonably requested by the Company). The Company shall not require Holder to provide an opinion of counsel if the
transfer is to SVB Financial Group (Silicon Valley Bank’s parent company) or any other affiliate of Holder, provided that any such transferee is an “accredited investor” as defined in Regulation D promulgated under the Act.
Additionally, the Company shall also not require an opinion of counsel if there is no material question as to the availability of Rule 144 promulgated under the Act; provided that, Holder represents that it has complied with Rule 144 in reasonable
detail, the selling broker represents that it has complied with Rule 144, and the Company is provided with a copy of Holder’s notice of proposed sale. 

5.4 Transfer Procedure. After receipt by Silicon Valley Bank of the executed Warrant, Silicon Valley Bank will transfer all of this
Warrant to its parent company, SVB Financial Group. By its acceptance of this Warrant, SVB Financial Group hereby makes to the Company each of the representations and warranties set forth in Section 4 hereof and agrees to be bound by all of the
terms and conditions of this Warrant as if the original Holder hereof. Subject to the provisions of Section 5.3 and upon providing the Company with written notice, SVB Financial Group and any subsequent Holder may transfer all or part of this
Warrant or the Shares issuable upon exercise of this Warrant (or the securities issuable directly or indirectly, upon conversion of the Shares, if any) to any transferee, provided, however, in connection with any such transfer, SVB Financial Group
or any subsequent Holder will give the Company notice of the portion of the Warrant being transferred with the name, address and taxpayer identification number of the transferee and Holder will surrender this Warrant to the Company for reissuance to
the transferee(s) (and Holder if applicable); and provided further, that any subsequent transferee other than SVB Financial Group shall agree in writing with the Company to be bound by all of the terms and conditions of this Warrant. Notwithstanding
any contrary provision herein, at all times prior to the IPO, Holder may not, without the Company’s prior written consent, transfer this Warrant or any portion hereof, or any Shares issued upon any exercise hereof, or any shares or other
securities issued upon any conversion of any Shares issued upon any exercise hereof, to any person or entity who directly competes with the Company, except in connection with an Acquisition of the Company by such a direct competitor. 

5.5 Notices. All notices and other communications hereunder from the Company to Holder, or vice versa, shall be deemed delivered and
effective (i) when given personally, (ii) on the third (3rd) Business Day after being mailed by first-class registered or certified mail, postage prepaid, (iii) upon actual
receipt if given by facsimile or electronic mail and such receipt is confirmed in writing by 

  
 8 

 
the recipient, or (iv) on the first Business Day following delivery to a reliable overnight courier service, courier fee prepaid, in any case at such address as may have been furnished to
the Company or Holder, as the case may be, in writing by the Company or such Holder from time to time in accordance with the provisions of this Section 5.5. All notices to Holder shall be addressed as follows until the Company receives notice
of a change of address in connection with a transfer or otherwise: 
 SVB Financial Group 

Attn: Treasury Department 

3003 Tasman Drive, HC 215 

Santa Clara, CA 95054 

Telephone: (408) 654-7400 

Facsimile: (408) 988-8317 

Email address: derivatives@svb.com 

Notice to the Company shall be addressed as follows until Holder receives notice of a change in address: 

Personalis, Inc. 

Attn: VP Finance & Administration 

1350 Willow Road 

Menlo Park, CA 94025 

Telephone: 650-752-1300 

Facsimile: 650-752-1301 

Email:                   
          
 5.6 Waiver. This Warrant and any term hereof may be changed, waived,
discharged or terminated (either generally or in a particular instance and either retroactively or prospectively) only by an instrument in writing signed by the party against which enforcement of such change, waiver, discharge or termination is
sought. 
 5.7 Attorney’s Fees. In the event of any dispute between the parties concerning the terms and provisions of this
Warrant, the party prevailing in such dispute shall be entitled to collect from the other party all costs incurred in such dispute, including reasonable attorneys’ fees. 

5.8 Counterparts; Facsimile/Electronic Signatures. This Warrant may be executed in counterparts, all of which together shall constitute
one and the same agreement. Any signature page delivered electronically or by facsimile shall be binding to the same extent as an original signature page with regards to any agreement subject to the terms hereof or any amendment thereto. 

5.9 Governing Law. This Warrant shall be governed by and construed in accordance with the laws of the State of Delaware, without giving
effect to its principles regarding conflicts of law. 
 5.10 Headings. The headings in this Warrant are for purposes of reference only
and shall not limit or otherwise affect the meaning of any provision of this Warrant. 
 5.11 Business Days. “Business
Day” is any day that is not a Saturday, Sunday or a day on which Silicon Valley Bank is closed. 
 [Signature page follows] 

  
 9 

 IN WITNESS WHEREOF, the parties have caused this Warrant to Purchase Stock to be executed by
their duly authorized representatives effective as of the Issue Date written above. 
 “COMPANY” 

PERSONALIS, INC. 
  

			
	By:	 	 /s/ John West

	Name:	 	John West
		 	(Print)
	Title:	 	CEO
	
	“HOLDER”
	
	SILICON VALLEY BANK
		
	By:	 	 /s/ Shawn Parry

	Name:	 	Shawn Parry
		 	(Print)
	Title:	 	V.P.

 APPENDIX 1  

NOTICE OF EXERCISE 
 1.
The undersigned Holder hereby exercises its right purchase                 shares of the Common/Series
                Preferred [circle one] Stock of PERSONALIS, INC. (the “Company”) in accordance with the attached Warrant To Purchase Stock, and
tenders payment of the aggregate Warrant Price for such shares as follows: 
  

	 	[    ]	 check in the amount of $
                payable to order of the Company enclosed herewith 

  

	 	[    ]	 Wire transfer of immediately available funds to the Company’s account 

 

	 	[    ]	 Cashless Exercise pursuant to Section 1.2 of the Warrant 

 

	 	[    ]	 Other [Describe]
                                         
                                         
                                         
                      

2. Please issue a certificate or certificates representing the Shares in the name specified below: 

 

					
		  	  
 Holder’s
Name
	  	
			
		  	  
	  	                                
			
		  	  
	  	
		  	 (Address)
	  	

 3. By its execution below and for the benefit of the Company, Holder hereby restates each of the
representations and warranties in Section 4 of the Warrant to Purchase Stock as of the date hereof. 
  

			
	HOLDER:
	  

		
	By:	 	          

	Name:	 	          

	Title:	 	          

	(Date):	 	          

  

  
 Appendix 1 

 SCHEDULE 1  

Company Capitalization Table 

See attached 

  
 Schedule 1

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