Document:

Exhibit 10.2

 

 

VENTURE LOAN AGREEMENT

 

By and between

 

Biophytis S.A.

 

as Issuer

 

and

 

Kreos Capital V (UK) Ltd.

 

As Subscriber

 

September 10th 2018

 

 

 

 

Table of contents

 

	
1.
    	
Definitions and   interpretation
    	
4
    
	
 
    	
 
    	
 
    
	
2.
    	
Bonds and Warrants   Issue
    	
7
    
	
 
    	
 
    	
 
    
	
3.
    	
Completion of issuance   of Tranche A
    	
7
    
	
 
    	
 
    	
 
    
	
4.
    	
Conditions Precedent to   the issuance of Tranche B, Tranche C and Tranche D
    	
8
    
	
 
    	
 
    	
 
    
	
5.
    	
Commitments
    	
8
    
	
 
    	
 
    	
 
    
	
6.
    	
Representations and   warranties
    	
11
    
	
 
    	
 
    	
 
    
	
7.
    	
Remedies and waivers
    	
13
    
	
 
    	
 
    	
 
    
	
8.
    	
Severability
    	
13
    
	
 
    	
 
    	
 
    
	
9.
    	
Notices
    	
13
    
	
 
    	
 
    	
 
    
	
10.
    	
Fees and expenses
    	
14
    
	
 
    	
 
    	
 
    
	
11.
    	
Law and jurisdiction
    	
15
    
	
 
    	
 
    	
 
    
	
Schedule   1
    	
16
    

 

2

 

Venture loan agreement

 

This venture loan agreement (hereinafter referred to as the “Venture Loan Agreement”) is entered into on September 10th, 2018, by and between:

 

1.                            Biopthytis S.A., a limited company (société anonyme) incorporated under the laws of France, with a share capital of EUR 2,692,682.60 having its registered office at 14, avenue de l’Opéra — 75001 Paris, France, registered under single identification number 492 002 225 RCS Paris, listed on the Euronext Growth organized multilateral trading facility under ISIN code FR0012816825, represented by Mr. Stanislas Veillet, in his capacity of chief executive officer (Président Directeur Général),

 

(hereinafter referred to as the “Issuer” or the “Company”)

 

ON THE FIRST PART

 

AND

 

2.                            Kreos Capital V (UK) Limited, a private limited company incorporated under the laws of England, having its registered office at 5th Floor, 25-28 Old Burlington Street, London W1S 3AN, United Kingdom, registered under identification number 09728300, represented by Mr. Maurizio Petitbon, in his capacity of Director, duly authorised for the purposes hereof;

 

(hereinafter referred to as the “Subscriber” or “Kreos”)

 

ON THE SECOND PART

 

Issuer and Subscriber being hereinafter referred to individually as a “Party” and collectively as the “Parties”.

 

Whereas

 

(A)                     The Subscriber is a venture debt provider, the business of which consists in making investments in high technology and life science companies throughout Europe.

 

(B)                     The Issuer is a French société anonyme, created in 2006, specializing in creating drugs to treat degenerative illnesses associated with aging for which no treatment is available to date. Its most advanced programmes relate to sarcopenia (loss of muscle functionality) and age-related macular degeneration (AMD).

 

(C)                     In order to finance the development of the Issuer’s business in general, the Subscriber has agreed to subscribe to a Bonds Issue by the Issuer for a nominal amount of up to ten million euros (EUR 10,000,000.00) as per a term sheet dated December 21st, 2017 and signed on December 22nd, 2017 (the “Term Sheet”).

 

(D)                     In accordance with the Term Sheet, on February 2nd, 2018, the Issuer paid to the Subscriber an amount of EUR 35,000.00 plus VAT (the “Deposit”) to cover costs, fees and expenses including, without limitation, costs of due diligence and fees of lawyers, valuers and consultants.

 

3

 

(E)                     On June 4th, 2018, the Issuer’s general meeting empowered, through its 8th resolution, the Issuer’s board of directors (conseil d’administration) to issue warrants giving access to the Issuer’s capital.

 

(F)                      On July 10 2018, the Issuer’s board of directors (conseil d’administration) empowered the chief executive officer (directeur general) of the Company to negotiate and enter into this Venture Loan Agreement and the related Issue Documents.

 

(G)                    The Parties have met to determine the terms and conditions of the transaction contemplated by the Term Sheet, which is the subject hereof.

 

NOW, THEREFORE, IT HAS BEEN AGREED AS FOLLOWS:

 

1.                            Definitions and interpretation

 

1.1                     In this Venture Loan Agreement, unless the context otherwise specifically provides, the following expressions shall have the following meanings:

 

	
Bonds
    	
 
    	
means the bonds (obligations within   the meaning assigned in article 213-5 of the French monetary and financial   Code) to be issued by the Issuer under the Bonds Issue;
    
	
 
    	
 
    	
 
    
	
Bonds Issue
    	
 
    	
means the issue of up to 10,000,000 Bonds carried   out pursuant to this Venture Loan Agreement in accordance with the Bonds   Issue Agreement;
    
	
 
    	
 
    	
 
    
	
Bonds Issue Agreement
    	
 
    	
means the bonds issue agreement entered into by the   Issuer and Subscriber in relation to the Bonds Issue and the Warrants as of   the date hereof;
    
	
 
    	
 
    	
 
    
	
Business Day
    	
 
    	
means a day (excepting Saturdays and Sundays) on   which banks operate in Paris;
    
	
 
    	
 
    	
 
    
	
Business Division Pledge   Agreement
    	
 
    	
means the pledge agreement entered into by the   Issuer and Subscriber as of the date hereof in relation to the pledged   business division as defined in article 3.2 of the Business Division Pledge   Agreement;
    
	
 
    	
 
    	
 
    
	
Completion Date
    	
 
    	
shall have the meaning set forth under section 3;
    
	
 
    	
 
    	
 
    
	
Deposit
    	
 
    	
shall have the meaning set forth in recital D of the   Preamble;
    
	
 
    	
 
    	
 
    
	
Drawdown Notice
    	
 
    	
shall have the meaning set forth in the Bonds Issue   Agreement;
    
	
 
    	
 
    	
 
    
	
Event of Default
    	
 
    	
shall have the meaning set forth in the Bonds Issue   Agreement;
    
	
 
    	
 
    	
 
    
	
Final Redemption Date
    	
 
    	
means the date on which all amounts due under the   Issue Documents have been unconditionally and irrevocably paid and discharged   in full;
    
	
 
    	
 
    	
 
    
	
Group
    	
 
    	
means the Issuer and any Subsidiary of the Issuer   from time to time;
    
	
 
    	
 
    	
 
    
	
Indebtedness
    	
 
    	
means (i) any outstanding amount to be repaid   pursuant to one or more credit facility agreements or the issue of bonds,   notes, debentures, loan stock or any similar instrument, and (ii) the   amount of any outstanding liability in respect of any guarantee for any of   the items referred to in paragraph (i), it being understood
    

 

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that any amount calculated under this definition may   only be counted once, even if an item may qualify under various paragraphs;   for the avoidance of doubt, any debt instruments issued as part of a variable   rate equity financing, including redeemable (or convertible) bonds with share   subscription warrants attached shall not be considered as Indebtedness;
    
	
 
    	
 
    	
 
    
	
Intellectual Property
    	
 
    	
means all subsisting intellectual property rights   owned by the Issuer (or Subsidiary) in any part of the world including   patents and rights of a similar nature, applications for patents and such   rights, divisions, prolongations, renewals, extensions, supplementary   protection certificates and continuations of such applications for patents,   registered and unregistered trademarks or trade names, registered and   unregistered service marks, registered and unregistered designs, utility   models (in each case for their full period and all extensions and renewals of   them), applications for any of them and the right to apply for any of them in   any part of the world, inventions, processes, software, formulae, technology   (whether patentable or not) data, specifications, business or trade secrets,   technical information, confidential information, know-how, business names,   brand names, domain names, database rights, copyright and rights in the   nature of database rights and copyright, design rights;
    
	
 
    	
 
    	
 
    
	
Issue
    	
 
    	
means the Bonds Issue and the issue of Warrants;
    
	
 
    	
 
    	
 
    
	
Issue Documents
    	
 
    	
means this Venture Loan Agreement, the Bonds Issue   Agreement, the Terms and Conditions of the Warrants, each of the Security   Documents, any document executed pursuant to any such document and any other   document designated as such in writing by the Issuer and the Subscriber;
    
	
 
    	
 
    	
 
    
	
Issuer
    	
 
    	
means Biopthytis S.A., a limited company (société anonyme) incorporated under the laws of France,   with a share capital of EUR 2,692,682.60 having its registered office at 14,   avenue de l’Opéra — 75001 Paris, France, registered under single   identification number 492 002 225 RCS Paris, listed on the Euronext   Growth organized multilateral trading facility under ISIN code ISIN   FR0012816825;
    
	
 
    	
 
    	
 
    
	
Newly Generated IP
    	
 
    	
means any Intellectual Property rights of the same   nature as those referred to in article 3.2 (ii) (a) and (b) of   the Business Division Pledge Agreement, which the Issuer or any Subsidiary   may become the owner of in any way whatsoever after the date of this   Agreement.
    
	
 
    	
 
    	
 
    
	
Person
    	
 
    	
shall mean and include an individual, a partnership,   a corporation, a business trust, a joint stock company, a limited liability   company, an unincorporated association or other entity and any domestic or   foreign national, state or local government, any political subdivision   thereof, and any department, agency, authority or bureau of any of the   foregoing;
    
	
 
    	
 
    	
 
    
	
Pledged Intellectual Property
    	
 
    	
means the Intellectual Property falling in the scope   of the Business Division Pledge Agreement from time to time;
    
	
 
    	
 
    	
 
    
	
Security Documents
    	
 
    	
means the Business Division Pledge Agreement and any   document entered into by any person (including Subsidiaries) from time to   time creating any Security Interest, directly or indirectly, for the   obligations of the Issuer under this Venture Loan Agreement and ancillary documents   at Subscriber’s request;
    
	
 
    	
 
    	
 
    
	
Security Interest
    	
 
    	
means any mortgage, charge, assignment, pledge,   lien, contractual right of set-off, hypothecation, encumbrance, priority or   other security interest or any 
    

 

5

 

	
 
    	
 
    	
arrangement which has substantially the same   commercial or substantive effect as the creation of security;
    
	
 
    	
 
    	
 
    
	
Subscriber(s)
    	
 
    	
means Kreos Capital V (UK) Limited any subsequent   Person(s) entered in the securities register which the Issuer under this   Agreement is required to maintain, as holder(s) of the Bonds;
    
	
 
    	
 
    	
 
    
	
Subsidiary
    	
 
    	
means, with respect to the Issuer,   (i) Instituto Biophytis Do Brasil Serviços, Comercio, Importação E   Exportação De Alimentos LTDA, a company registered under the laws of Brasil   with a share capital of BRL 898.632, whose registered office is located at   Av. Prof. Lineu Prestes N°2.242 Cidade Universitaria, na cidade de São Paulo,   Estade de São Paulo, CEP 05508-000, Setor D, Bloco 4, CIETEC and registered   under number CNPJ/MF 08.308.555/0001-07, (ii) Biophytis Inc., a company   registered under the laws of the State of Delaware with a share capital of   USD 1,000, whose registered office is located at Corpomax Inc, 2915 Ogletown   Rd, NEWARK, DE 19713 and registered under number 5873213 and (iii) any   other person which would come to be directly or indirectly controlled by or   under direct or indirect control of the Issuer. For purpose of this   definition, control shall have the meaning ascribed to “contrôle”   under article L.233-3 of the French Commercial Code;
    
	
 
    	
 
    	
 
    
	
Terms and Conditions of the   Warrants
    	
 
    	
means the terms and conditions of the Warrants as   set forth in Schedule 2.2 (b) of the Bonds Issue Agreement.
    
	
 
    	
 
    	
 
    
	
Warrants
    	
 
    	
means the warrants (bons de   souscription d’action) governed by the provisions of article   228-91 of the French commercial Code to be issued by Issuer and attached to   Tranche A under the Bonds Issue Agreement.
    

 

1.2                     In this Venture Loan Agreement, except as otherwise provided or where clearly inconsistent in the light of the context:

 

	
(i)
    	
 
    	
words importing the singular include the plural and vice versa;
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
words denoting gender include every gender;
    
	
 
    	
 
    	
 
    
	
(iii)
    	
 
    	
words denoting persons include bodies corporate or unincorporate;
    
	
 
    	
 
    	
 
    
	
(iv)
    	
 
    	
a section, clause, sub-clause or Schedule is to a   section, clause, sub-clause or Schedule, as the case may be, of or to this   Venture Loan Agreement;
    
	
 
    	
 
    	
 
    
	
(v)
    	
 
    	
any provision of a statute shall be construed as a   reference to that provision as amended, modified, re-enacted or extended from   time to time;
    
	
 
    	
 
    	
 
    
	
(vi)
    	
 
    	
words and expressions in the French language defined   in the French Commercial Code (Code de commerce)   or the French Monetary and Financial Code (Code   monétaire et financier) as amended shall bear the same meanings   herein, and
    
	
 
    	
 
    	
 
    
	
(vii)
    	
 
    	
capitalised terms not defined herein shall have the   meaning given to them in the Bonds Issue Agreement.
    

 

1.3                     The headings in this Venture Loan Agreement are for ease of reference only and shall not affect the construction of this Agreement.

 

1.4                     Should any conflicts occur between this Agreement and any of the Issue Documents, the Parties agree that this Venture Loan Agreement’s provisions shall prevail.

 

6

 

2.                            Bonds and Warrants Issue

 

2.1                     Subject to the deliveries and the conditions precedent set forth in article 3 and 4 hereof, Issuer shall issue and Subscriber shall subscribe to (i) Warrants and (ii) Bonds for a total nominal amount of up to ten million Euros (EUR 10,000,000.00), with a par value of EUR 1.00 per Bond covering several tranches as follows:

 

	
(i)
    	
 
    	
A   first tranche of Bonds (the “Tranche A”)   for a total nominal amount of EUR 2,500,000.00 divided into   (i) 2,057,523 Bonds and (ii) 442,477 Bonds with Warrants attached,   to be subscribed at Issuer’s discretion subject to the deliveries set forth   in article 3 below, in a single full drawdown, on the Completion Date   (subject to clause 2.2 below). Warrants, having the characteristics described   in Appendix 2.2(b) of the Bonds Issue Agreement, shall be attached to   the Tranche A Bonds, the number of which shall be determined as provided in   clause 2.2 of the Bonds Issue Agreement.
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
A   second tranche of Bonds (“Tranche B”)   for a total nominal amount of EUR 2,500,000.00, to be subscribed at Issuer’s   discretion, subject to the conditions precedent set forth in article 4 below,   in a single full drawdown, at any time from and subject to the cumulative   fulfilment of such conditions until September 30th, 2018 (subject to clause 2.2 below).
    
	
 
    	
 
    	
 
    
	
(iii)
    	
 
    	
A   third tranche of Bonds (“Tranche C”)   for a total nominal amount of EUR 2,500,000.00, to be subscribed at Issuer’s   discretion, subject to the conditions precedent set forth in article 4 below,   in a single full drawdown, at any time from and subject to the cumulative   fulfilment of such conditions until December 31st, 2018 (subject to clause 2.2 below).
    
	
 
    	
 
    	
 
    
	
(iv)
    	
 
    	
A   fourth tranche of Bonds (“Tranche D”)   for a total nominal amount of EUR 2,500,000.00, to be subscribed at Issuer’s   discretion, subject to the conditions precedent set forth in article 4 below,   in a single full drawdown, at any time from and subject to the cumulative   fulfilment of such conditions until March 31st, 2019 (subject to clause 2.2 below).
    

 

2.2                     In the event one or several of the Tranches has not been drawn by Issuer during its respective availability period, the Issuer may defer the drawdown of one single undrawn Tranche, subject to the deliveries and conditions precedent set forth in articles 3 and 4 below, and draw such Tranche in a single drawdown, at any time from and subject to the cumulative fulfilment of such deliveries and conditions between April 1st, 2019 and June 30th, 2019.

 

2.3                     The issue of the Bonds, their ranking, applicable interests and repayment schedules, and all relevant provisions shall be governed by a bonds issue agreement in the form of Schedule 2 hereto (the “Bonds Issue Agreement”).

 

3.                            Completion of issuance of Tranche A

 

The effective subscription of Tranche A Bonds in accordance with the terms of the Bonds Issue Agreement will take place on the date of execution of this Venture Loan Agreement upon fulfilment of the last of the following deliveries which are provided for to the sole benefit of the Subscriber (the “Completion Date”), who may waive them in writing, being specified that if such deliveries are not communicated, and not waived by the Subscriber, this Venture Loan Agreement will be terminated, without prejudice to any rights which have accrued to any Party prior to such termination and to the surviving provisions of this Venture Loan Agreement, and the Parties hereto will be released on this date from any commitment resulting herefrom except for those resulting from article 11 below (being however specified, for the avoidance of doubt, that the Subscriber shall be entitled to permanently retain the Deposit):

 

(i)                           Approval by the Issuer’s chief executive officer (directeur general), in accordance with the provisions of article L.225-35 of the French commercial Code, of (a) the terms and conditions of the Bonds Issue Agreement in agreed form, (b) the granting of the Security Interest created under the Security Documents in relation to the Bonds Issue and, (c) the terms and conditions of the Security Documents

 

7

 

in agreed form, and (d) the Terms and Conditions of the Warrants in agreed form, in accordance with the draft terms and conditions attached as Appendix 2.2(b) of the Bonds Issue Agreement in Schedule 2 hereto;

 

(ii)                        Execution by the Parties of the Bonds Issue Agreement and the Security Documents;

 

(iii)                     Issuance of the Tranche A Bonds with Warrants attached by the Issuer’s chief executive officer (directeur général) in accordance with the terms and conditions of the Bonds Issue Agreement;

 

(iv)                    Confirmation by the Issuer that there is (and shall be on the funding date), no other external indebtedness than the existing indebtedness constituted of:

 

·                               Subsidy by BPIFrance Financement for an amount of EUR 228,782.82 for “Développement Clinique d’un extrait de Quinoa actif sur le Syndrome Métabolique”;

 

·                               Subsidy by BPIFrance Financement for an amount of EUR 1,100,000 for “Production des lots cliniques, phase préclinique réglementaire et Clinique de phase 1 de BIO101 pour le traitement de l’obésité sarcophénique” dated November 30th 2016;

 

·                               Subsidy by BPIFrance Financement for an amount of EUR 260,000 for “Caractérisation in vitro, in vivo et pharmacocinétique d’un candidat medicament” dated December 4th 2015; and

 

·                               Seed participating loan OSEO for an amount of EUR 150,000 dated November 4th 2008.

 

(v)                       Confirmation by the Issuer that no Event of Default has occurred or is continuing (or will be continuing on the funding date);

 

(vi)                    The Issuer having served a first Drawdown Notice five (5) Business Days before the requested subscription and funding date.

 

4.                            Conditions Precedent to the issuance of Tranche B, Tranche C and Tranche D

 

The Subscriber’s commitment to subscribe to the Bonds under Tranche B, Tranche C or Tranche D (at Issuer’s discretion but only in whole) shall be subject to the following conditions, all of which are provided for to the sole benefit of the Subscriber who may waive them in writing before the end of the relevant availability period:

 

	
(i)
    	
 
    	
The   actual full drawdown of Tranche A,
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
The   absence on the date of the Drawdown Notice in accordance with the Bonds Issue   Agreement of a continuing Event of Default (within the meaning assigned in   the Bonds Issue Agreement) under any already drawn Tranche,
    
	
 
    	
 
    	
 
    
	
(iii)
    	
 
    	
The Issuer having served a   Drawdown Notice fifteen (15) days before the requested subscription and   funding date, which will not be later than the expiry date of the   availability of such Tranche as set forth in the relevant paragraph of clause   2.1 (or 2.2 in relation to a carried Tranche).
    

 

5.                            Commitments

 

5.1                     The Issuer undertakes with the Subscriber that, from the date of this Venture Loan Agreement and for so long as any amount is or may be outstanding under this Venture Loan Agreement, and except with the prior written consent of the Subscriber, it shall:

 

8

 

5.1.1           Authorisations

 

obtain, maintain in force and effect and comply in all material respects with the terms of all authorisations, approvals, licences, exemptions, notarisations and consents required in or by any applicable laws and regulations in connection with its business;

 

5.1.2           Litigation

 

promptly upon becoming aware of them, deliver to the Subscriber details of any material litigation, arbitration or administrative proceedings which are current or pending, and which can reasonably be considered as likely to, if adversely determined, have a Material Adverse Effect (as defined in the Bonds Issue Agreement); or result in a cost or liability for the Issuer of more than EUR 200,000;

 

5.1.3           Events of Default

 

promptly inform the Subscriber of the occurrence of any Event of Default (within the meaning assigned in the Bonds Issue Agreement) and, upon receipt of a written request to that effect from the Subscriber, confirm to the Subscriber that, save as previously notified to the Subscriber or as notified in that confirmation, no such event has occurred;

 

5.1.4           Negative pledge

 

without prejudice to the Security Documents and save as otherwise authorized in such Security Documents, not:

 

	
(i)
    	
 
    	
create, purport to create or allow to subsist, any   Security Interest over the whole or any part of the Pledged Intellectual   Property Rights (or any other charged asset) other than in the ordinary   course of business; or
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
permit or agree to any variation of the rights   attaching to the whole or any part of any asset affected by a Security   Interest other than the Business Division Pledge Agreement; or
    
	
 
    	
 
    	
 
    
	
(iii)
    	
 
    	
convey, assign, transfer, or agree to convey, assign   or transfer the whole or any part of the any asset affected by a Security   Interest other than the Business Division Pledge Agreement; or
    
	
 
    	
 
    	
 
    
	
(iv)
    	
 
    	
while any amount is outstanding in relation to this   Venture Loan Agreement, pledge or dispose in any other way, without   Subscriber’s prior written consent or as authorised in the Security   Documents, of all or part of the Intellectual Property rights other than the   Pledged Intellectual Property rights. It being specified that a breach of   such commitment shall be an Event of Default (within the meaning assigned in   the Bonds Issue Agreement) and shall entitle Subscriber to recover all   outstanding amounts under this Venture Loan Agreement and ancillary   documents.
    

 

In the event the conditions to the release of the Security Interest as set forth in clause 13.4 of the Business Division Pledge Agreement would not be met, the Subscriber and Issuer will negotiate in good faith alternative solutions to preserve both the Subscriber’s global level of Security Interest and the Issuer’s commercial attractivity.

 

5.1.5           Distribution of dividends

 

So long as any amount is or may be outstanding under this Venture Loan Agreement and ancillary documents, Issuer shall refrain from distributing any dividends or any other amounts eligible under French corporate law without the prior formal consent of Kreos in writing.

 

9

 

5.1.6           Insurance

 

So long as any amount is or may be outstanding under this Venture Loan Agreement, the Issuer shall obtain and maintain at its own expense insurance cover in relation to its business and assets of a type and in an amount as is usual for prudent companies its size carrying on a business such as that carried on by it.

 

5.1.7           Indebtedness

 

Unless otherwise expressly authorised by Subscriber, not to incur any new Indebtedness, with the exception of the following:

 

	
(i)
    	
 
    	
Indebtedness up to EUR   100,000 incurred in the normal course of business (or with the prior written   approval of the Borrower) provided it is unsecured and subordinated to the   Bonds in all respects,
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
Any unsecured Indebtedness   made available by public agencies (BPI France and alike) incurred for the   purposes of financing research and development which shall be considered as   incurred in the normal course of business, provided they are unsecured and   expressly subordinated to the Bonds and Warrants in all respects, and, more   generally, that relevant agreements contain usual provisions in such matters   and do not adversely affect the position of the Subscriber as a creditor, and
    
	
 
    	
 
    	
 
    
	
(iii)
    	
 
    	
Indebtedness resulting from   a sale and lease back arrangement on real estate property.
    

 

5.1.8           Subordination

 

Unless otherwise expressly authorised by Subscriber, not to enter into any Indebtedness senior to any rights and interests created by (i) this Agreement, and (ii) the Bonds Issue Agreement.

 

5.2                     The Issuer further undertakes that, from the date of this Venture Loan Agreement and for so long as any amount is or may be outstanding under this Venture Loan Agreement, the Subscriber will have the right to:

 

	
(i)
    	
 
    	
receive   all information sent to the board of directors (conseil d’administation) of the   Borrower at the same time as their members;
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
receive   annual audited consolidated financial statements within 180 days of year-end   or, if sooner, at the same time they are provided to any investor in the   Issuer; and
    
	
 
    	
 
    	
 
    
	
(iii)
    	
 
    	
receive   annual operating, budgets and projections (and revisions thereto) within 10   days of board approval
    

 

Subscriber acknowledges that, as a consequence, from the date of this Venture Loan Agreement, it will be listed as a permanent insider with respect to Issuer.

 

5.3                     Until the Final Redemption Date, and for the first time on 30 June 2019, the Issuer and the Subscriber shall conduct a yearly review of the Newly Generated Intellectual Property based on the Issuer’s activity and financial position. To the extent that, upon completion of such yearly review, the Subscriber, acting reasonably and in good faith, determines that the value of the Pledged Intellectual Property has decreased to a point where the Subscriber’s receivable against the Issuer under the Bonds Issue Agreement is no longer adequately protected, the Issuer and the Subscriber shall jointly determine in good faith which Newly Generated Intellectual Property rights to include in the scope of the Business Division Pledge Agreement in accordance with the provisions of section 3.2 (c) of such agreement in order to compensate for such decrease.

 

10

 

In the event of a dispute between the Issuer and the Subscriber in connection with the outcome of such review and/or grant of a pledge over Newly Generated Intellectual Property, it will be resolved in accordance with the expertise process set forth in the provisions of section 17 of the Business Division Pledge agreement.

 

6.                            Representations and warranties

 

The Issuer makes the representations and warranties in clause 6.1 to clause 6.14 on the date of this Agreement, and, where applicable, on each Interest Payment Date (as defined in the Bonds Issue Agreement), by reference to the facts and circumstances existing on each such date. The Issuer acknowledges that the Subscriber has subscribed the Bonds and Warrants in reliance to those representations and warranties.

 

6.1                     Due incorporation

 

	
(i)
    	
 
    	
It is a duly incorporated limited liability company   validly existing under the law of its jurisdiction of incorporation; and
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
It has the power to own its assets and carry on its   business as it is being conducted.
    

 

6.2                     Powers

 

It has the power and authority to execute, deliver and perform its obligations under the Issue Document and the transactions contemplated by them.

 

6.3                     Non-contravention

 

The execution, delivery and performance of the obligations in, and transactions contemplated by, the Issue Document to which it is a party do not and will not contravene or conflict with:

 

	
(i)
    	
 
    	
its constitutional documents;
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
any agreement or instrument binding on it or   constitute a default or termination event (however described) under any such   agreement or instrument; or
    
	
 
    	
 
    	
 
    
	
(iii)
    	
 
    	
to the knowledge of the Issuer, any law or   regulation or judicial or official order, applicable to it.
    

 

6.4                     Authorisations

 

It has taken all necessary action and obtained all required or desirable authorisations to enable it to execute, deliver and perform its obligations under the Issue Documents and the transactions contemplated by them and to make them admissible in evidence in its jurisdiction of incorporation. Any such authorisations are in full force and effect.

 

6.5                     Binding obligations

 

	
(i)
    	
 
    	
its obligations under the Issue Document to which it   is a party are legal, valid, binding and enforceable; and
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
the Security Documents create (or, once entered   into, will create) valid, legally binding and enforceable Security Interests   for the obligations expressed to be secured by them.
    

 

11

 

6.6                     Choice of law

 

The choice of governing law of the Issue Documents will be recognised and enforced in its relevant jurisdictions.

 

Any judgement obtained in relation to an Issue Document in the jurisdiction of the governing law of that Issue Document will be recognised and enforced in its relevant jurisdictions.

 

6.7                     No default

 

No Event of Default has occurred or is continuing.

 

6.8                     Information

 

The information, in written or electronic format, supplied to the Subscriber by the Issuer or on its behalf in connection with the Issue and the Issue Document was, at the time it was supplied or at the date it was stated to be given (as the case may be):

 

	
(i)
    	
 
    	
if it was factual information true and accurate in   all material respects; and
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
not misleading in any material respect, nor rendered   misleading by a failure to disclose other information,
    

 

except to the extent that it was amended, superseded or updated by more recent information supplied to the Subscriber by the Issuer or on its behalf.

 

6.9                     Financial statements

 

Each set of financial statements delivered to the Subscriber in respect of the Issuer was prepared in accordance with standards and practices generally accepted in its jurisdiction of incorporation and gives a true and fair view of (if audited) or fairly represents (if unaudited) its financial condition and operations during the relevant accounting period and was approved by its directors in compliance with applicable laws.

 

6.10              No material adverse change

 

There has been no material adverse change in the business, assets, financial condition or trading position of the Issuer since the date of this agreement.

 

6.11              No litigation

 

No litigation, arbitration or administrative proceedings are taking place, pending or, to the Issuer knowledge, threatened against the Issuer, any of its directors or any of its assets, which, is likely to be adversely determined and if adversely determined, might reasonably be expected to have a Material Adverse Effect (as defined in the Bonds Issue Agreement).

 

6.12              Pari passu

 

Its payment obligations under the Issue Documents rank at least pari passu with all existing and future unsecured and unsubordinated obligations (including contingent obligations), except for those mandatorily preferred by law applying to companies generally.

 

6.13              Ownership of material assets

 

It is the legal and beneficial owner of, and has valid a title to, all its material assets and no Security Interest exists over its assets except for the security created by the Security Documents.

 

12

 

6.14              Centre of main interests and establishments

 

For the purposes of Council Regulation 1346/2000 on insolvency proceedings (Insolvency Regulation), its “centre of main interests” (as that term is used in article 3(1) of the Insolvency Regulation) is its jurisdiction of incorporation.

 

7.                            Remedies and waivers

 

7.1                     No failure, delay or other relaxation or indulgence on the part of the Subscriber to exercise any power, right or remedy shall operate as a waiver thereof nor shall any single or partial exercise or waiver of any power, right or remedy preclude its further exercise or the exercise of any other power, right or remedy.

 

7.2                     All rights of the Subscriber contained in this Venture Loan Agreement are in addition to all rights vested or to be vested in it pursuant to the other Issue Documents, common law or statute.

 

7.3                     Each Party hereby acknowledges that the provisions of article 1195 of the French Code civil shall not apply to it with respect to its obligations under the Issue Documents and that it shall not be entitled to make any claim under article 1195 of the French Code civil.

 

8.                            Severability

 

Each of the provisions of this Venture Loan Agreement is severable and distinct from the others and if at any time one or more of such provisions is or becomes invalid, illegal or unenforceable the validity, legality and enforceability of the remaining provisions hereof shall not in any way be affected or impaired thereby.

 

9.                            Notices

 

9.1                     All notices, demands or other communications under or in connection with this Venture Loan Agreement may be given by letter, facsimile or other comparable means of communication addressed to the person at the address identified with its signature below.

 

	
To Issuer:
    	
 
    	
Biophytis S.A.
    
	
 
    	
 
    	
A l’attention de Monsieur Stanislas Veillet
    
	
 
    	
 
    	
Président Directeur Général
    
	
 
    	
 
    	
and Monsieur Jean-Christophe Montigny
    
	
 
    	
 
    	
Directeur administratif et financier
    
	
 
    	
 
    	
14, avenue de l’Opera
    
	
 
    	
 
    	
75001 Paris
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
E-mail: stanislas.veillet@biophytis.com and   jc.montigny@biophytis.com
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
With copy (for information purposes) to:
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Monsieur Marc Fredj
    
	
 
    	
 
    	
Avocat associé
    
	
 
    	
 
    	
Reed Smith LLP
    
	
 
    	
 
    	
112, avenue Kléber
    
	
 
    	
 
    	
75116 Paris
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
E-mail: mfredj@reedsmith.com
    

 

13

 

	
 
    	
 
    	
Fax: 01.76.70.41.19
    
	
 
    	
 
    	
 
    
	
To Subscriber:
    	
 
    	
Kreos Capital V (UK) Ltd.
    
	
 
    	
 
    	
To the attention of Mr. Maurizio Petitbon
    
	
 
    	
 
    	
5th Floor, 25-28   Old Burlington Street
    
	
 
    	
 
    	
London W1S 3AN
    
	
 
    	
 
    	
United Kingdom
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Email: maurizio@kreoscapital.com
    
	
 
    	
 
    	
Fax: +44 20 7409 1034
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
With copy (for information purposes) to:
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Monsieur Laurent Cavallier
    
	
 
    	
 
    	
Avocat associé
    
	
 
    	
 
    	
Reinhart Marville Torre
    
	
 
    	
 
    	
58, avenue Kleber
    
	
 
    	
 
    	
75116 Paris
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
E-mail: cavallier@rmt.fr
    
	
 
    	
 
    	
Fax: +33 (0)1 53 96 04 20
    

 

9.2                     Any such communication will be deemed to be given as follows:

 

	
(i)
    	
 
    	
if personally delivered, at the time of delivery, as   documented by a receipt;
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
if by letter, on the date entered by the addressee   on the receipt in the case of delivery by hand or on the date when delivery   is first attempted in the case of a recorded delivery letter with   acknowledgement of receipt; and
    
	
 
    	
 
    	
 
    
	
(iii)
    	
 
    	
if by email transmission or comparable means of   communication during the business hours of the addressee then on the day of   transmission, otherwise on the next following Business Day.
    

 

9.3                     In proving such service it shall be sufficient to prove that personal delivery was made or that such letter was properly stamped first class, addressed and delivered to the postal authorities or in the case of email transmission or other comparable means of communication that a confirming hard copy was provided promptly after transmission.

 

10.                     Fees and expenses

 

10.1              On Completion Date, Issuer shall pay to Subscriber a transaction fee equal to one point twenty-five per cent (1.25 %) of the global amount of the Bonds Issue, i.e. EUR 125,000.00. Subscriber may set off such fee against the subscription price of the Tranche A Bonds.

 

10.2              The Issuer will cover its own legal costs and all Subscriber’s reasonable legal costs relating to the negotiation, preparation and execution of the Venture Loan Agreement, Issue Documents and ancillary documents and the completion of the transactions in connection therewith, up to an amount of EUR 35,000.00 (excluding VAT and costs). The Issuer will be responsible for all expenses in connection with the security including taxes assessments, insurance premiums, all costs of operation, repair and maintenance of equipment and other assets used as security and any fees and taxes relating to security filings.

 

14

 

The Subscriber is hereby expressly authorised to use the outstanding balance of the Deposit to cover such costs, being specified the balance of the Deposit, if any, shall be repaid by the Subscriber upon drawdown of Tranche A.

 

10.3              The Issuer shall pay all stamp, documentary, registration and other like duties or taxes to which this Venture Loan Agreement, or any judgment given in connection with this Venture Loan Agreement is or at any time may be subject and shall, from time to time on demand of the Subscriber, forthwith indemnify the Subscriber against any liabilities, costs, claims and expenses reasonably incurred as a result of any failure to pay or any delay in paying any such amounts

 

10.4              At each Discharge Date (within the meaning of the Bonds Issue Agreement), or in case of termination or expiry of the Issue Documents, the Issuer shall pay an additional sum equal to four per cent (4.00 %) of the amounts drawn down under the relevant Tranche (or the cumulated drawn Tranches in case of a termination or expiry of the Issue Documents).

 

10.5              All fees and expenses payable pursuant to this article are excluding VAT and shall be paid together with VAT (if any) properly chargeable thereon.

 

10.6              From the Final Redemption Date, the Subscriber shall promptly release all its Security Interest.

 

11.                     Law and jurisdiction

 

11.1              This Venture Loan Agreement is governed by and shall be construed in accordance with French law.

 

11.2              Any dispute concerning the validity, interpretation or performance of this Venture Loan Agreement will be submitted to the Tribunal de commerce (commercial court) of Paris.

 

Executed in Paris

in two (2) originals

On September 10th, 2018

 

 

	
/s/ Stanislas Veillet
    	
 
    	
/s/ Maurizio Petitbon
    
	
Biophytis   S.A.
    	
 
    	
Kreos Capital V (UK) Limited
    
	
Mr. Stanislas   Veillet
    	
 
    	
Mr. Maurizio Petitbon
    

 

15

 

Schedule 1

 

Template Bonds Issue Agreement

 

16Exhibit 10.3

 

 

BONDS ISSUE AGREEMENT

 

By and between

 

Biophytis S.A.

 

as Issuer

 

and

 

Kreos Capital V (UK) LTD.

 

As Subscriber

 

September 10th 2018

 

 

 

 

Table of contents

 

	
1.
    	
Definitions and   interpretation
    	
4
    
	
 
    	
 
    	
 
    
	
2.
    	
Issue and subscription
    	
7
    
	
 
    	
 
    	
 
    
	
3.
    	
Purpose of the Issue
    	
8
    
	
 
    	
 
    	
 
    
	
4.
    	
Ranking
    	
8
    
	
 
    	
 
    	
 
    
	
5.
    	
Interest
    	
8
    
	
 
    	
 
    	
 
    
	
6.
    	
Repayment, purchase and   cancellation
    	
9
    
	
 
    	
 
    	
 
    
	
7.
    	
Taxation
    	
9
    
	
 
    	
 
    	
 
    
	
8.
    	
Undertakings
    	
10
    
	
 
    	
 
    	
 
    
	
9.
    	
Events of default
    	
10
    
	
 
    	
 
    	
 
    
	
10.
    	
Register and   certificates
    	
12
    
	
 
    	
 
    	
 
    
	
11.
    	
Transmission and   transfer
    	
13
    
	
 
    	
 
    	
 
    
	
12.
    	
Procedures for payment
    	
13
    
	
 
    	
 
    	
 
    
	
13.
    	
Rights of single or   multiple Bondholders and Warrant Holders
    	
13
    
	
 
    	
 
    	
 
    
	
14.
    	
Remedies and waivers
    	
14
    
	
 
    	
 
    	
 
    
	
15.
    	
Severability
    	
14
    
	
 
    	
 
    	
 
    
	
16.
    	
Notices
    	
14
    
	
 
    	
 
    	
 
    
	
17.
    	
Law and jurisdiction
    	
16
    
	
 
    	
 
    	
 
    
	
List of Appendixes
    	
17
    

 

2

 

Bonds Issue Agreement

 

This agreement (hereinafter referred to as the “Agreement” or “Bonds Issue Agreement”) is entered into on September 10th, 2018, by and between:

 

1.                            Biopthytis S.A., a limited company (société anonyme) incorporated under the laws of France, with a share capital of EUR 2,692,682.60 having its registered office at 14, avenue de l’Opéra — 75001 Paris, France, registered under single identification number 492 002 225 RCS Paris, listed on the Euronext Growth organized multilateral trading facility under ISIN code FR0012816825, represented by Mr. Stanislas Veillet, in his capacity of chief executive officer (Président Directeur Général),

 

(hereinafter referred to as the “Issuer”)

 

ON THE FIRST PART

 

AND

 

2.                            Kreos Capital V (UK) Limited, a private limited company incorporated under the laws of England, having its registered office at 5th Floor, 25-28 Old Burlington Street, London W1S 3AN, United Kingdom, registered under identification number 09728300, represented by Mr. Maurizio Petitbon, in his capacity of Director, duly authorised for the purposes hereof;

 

(hereinafter referred to as the “Subscriber” or “Kreos”)

 

ON THE SECOND PART

 

Issuer and Subscriber being hereinafter referred to individually as a “Party” and collectively as the “Parties”.

 

Whereas

 

(A)                     The Subscriber is a venture debt provider, the business of which consists in making investments in high technology and life science companies throughout Europe.

 

(B)                     The Issuer is a French société anonyme, created in 2006, specializing in creating drugs to treat degenerative illnesses associated with aging for which no treatment is available to date. Its most advances programmes relate to sarcopenia (loss of muscle functionality) and age-related macular degeneration (armd).

 

(C)                     In order to finance the development of the Issuer’s business in general, the Subscriber has agreed to subscribe to an issue of Bonds and Warrants by the Issuer for a nominal amount of up to ten million euros (EUR 10,000,000.00) subject to and upon the terms and conditions of the venture loan agreement entered into between the Parties on the date herof (hereinafter referred to as the “Venture Loan Agreement”).

 

(D)                     The Parties have agreed upon the terms and conditions of the Issue as set forth herein.

 

3

 

NOW, THEREFORE, IT HAS BEEN AGREED AS FOLLOWS:

 

1.                            Definitions and interpretation

 

1.1                     In this Agreement, unless the context otherwise specifically provides, the following expressions shall have the following meanings:

 

	
Agreement
    	
 
    	
shall have the meaning set forth in the preamble;
    
	
 
    	
 
    	
 
    
	
Bondholder(s)
    	
 
    	
means the person(s), including the Subscriber and   any subsequent person(s) entered in the Register which the Issuer is   required to maintain under this Agreement, as holder(s) of Bonds and as   may be represented by the bondholders’ representative (représentant   de la masse);
    
	
 
    	
 
    	
 
    
	
Bonds
    	
 
    	
means the bonds (obligations   within the meaning assigned in article 213-5 of the French monetary and   financial Code) issued in Euros by the chief executive officer (directeur general) of the Issuer in accordance with this   Agreement and decisions of the board of directors (conseil   d’administration) of the Issuer dated July 10th 2018 empowering the chief executive officer   (directeur general) of the Company to   negotiate and enter into a venture loan agreement of EUR 10,000,000 divided   into 4 tranches with 10% of warrants (bons de souscription   d’actions) and a pledge over business division pursuant to   decisions of the Issuer’s general meeting dated June 4th 2018 empowering, through its 8th resolution, the Issuer’s board of directors   (conseil d’administration) to issue   warrants giving access to the Issuer’s capital;
    
	
 
    	
 
    	
 
    
	
Business Day
    	
 
    	
means a day (excepting Saturdays and Sundays) on   which banks operate in Paris;
    
	
 
    	
 
    	
 
    
	
Change of Control
    	
 
    	
means the de-listing of the Issuer;
    
	
 
    	
 
    	
 
    
	
Discharge Date
    	
 
    	
means with respect to any drawdown under any Tranche,   the 36th Repayment Date (or such date of actual early   payment in case of a Prepayment or acceleration of the Bonds or more   generally such earlier date or dates as the same shall become repayable in   accordance with this Agreement and/or the Venture Loan Agreement);
    
	
 
    	
 
    	
 
    
	
Drawdown Date
    	
 
    	
means with respect to any drawdown under any   Tranche, the day on which the Bonds are subscribed and paid up by the   Subscriber;
    
	
 
    	
 
    	
 
    
	
Drawdown Notice
    	
 
    	
means a notice from Issuer requesting Subscriber to   subscribe to Bonds in accordance with this Agreement;
    
	
 
    	
 
    	
 
    
	
Event of Default
    	
 
    	
means any of those events set out in Article 9   (Events of Default);
    
	
 
    	
 
    	
 
    
	
Final Redemption Date
    	
 
    	
means the date on which all amounts due under the   Issue Documents have been unconditionally and irrevocably paid and discharged   in full;
    
	
 
    	
 
    	
 
    
	
First Interest Payment Date
    	
 
    	
means with respect to any drawdown under any   Tranche, the first day of a calendar month being or following the date of   drawdown, as specified in the Drawdown Notice;
    

 

4

 

	
Interest Payment
    	
 
    	
means interest payments due by the Issuer to the   Subscriber pursuant to this Agreement;
    
	
 
    	
 
    	
 
    
	
Interest Payment Date
    	
 
    	
means with respect to any drawdown under any   Tranche, the First Interest Payment Date, and then the first Business Day of   each subsequent calendar month;
    
	
 
    	
 
    	
 
    
	
Interest Period
    	
 
    	
means with respect to any drawdown under any   Tranche, a period commencing on and including an Interest Payment Date and   ending on the day prior to the next following Interest Payment Date. Every   Interest Period shall have a duration of one calendar month, being however   specified that (i) in the event any Drawdown Date would not be the First   Interest Payment Date, interest will accrue on the period elapsing between   the Drawdown Date and the First Interest Payment Date in accordance with the   provisions of Article 5.1 and 5.2, and (ii) in the event the   Discharge Date is later than the 36th Interest Period, the last Interest Period   will commence on the date of the Interest Payment Date immediately preceding   the Discharge Date and end on such Discharge Date;
    
	
 
    	
 
    	
 
    
	
Issue
    	
 
    	
means the issue of (i) Warrants and   (ii) 10,000,000 Bonds carried out by the chief executive officer (directeur général) of the Issuer pursuant to this   Agreement;
    
	
 
    	
 
    	
 
    
	
Issue Documents
    	
 
    	
has the meaning ascribed to it in the Venture Loan   Agreement;
    
	
 
    	
 
    	
 
    
	
Material Adverse Effect
    	
 
    	
means a material adverse effect on either the   business / or the operations of the Issuer, and its ability to comply with   any of its payment obligations under the Agreement;
    
	
 
    	
 
    	
 
    
	
Person
    	
 
    	
shall mean and include an individual, a partnership,   a corporation, a business trust, a joint stock company, a limited liability   company, an unincorporated association or other entity and any domestic or   foreign national, state or local government, any political subdivision   thereof, and any department, agency, authority or bureau of any of the   foregoing;
    
	
 
    	
 
    	
 
    
	
Prepayment
    	
 
    	
has the meaning ascribed to it in Article 6.3;
    
	
 
    	
 
    	
 
    
	
Register
    	
 
    	
has the meaning ascribed to it in Article 10.2;
    
	
 
    	
 
    	
 
    
	
Repayment Date
    	
 
    	
means with respect to any drawdown under any   Tranche, for the first time, April 1st, 2019 (or, as regards any   Tranche drawn under the provisions of clause 2.5, the first Interest Payment   Date in, relation to the relevant Tranche), and then subsequent Interest   Payment Dates (or the date of any Prepayment or acceleration of the Bonds or   more generally such earlier date or dates as the same shall become repayable   in accordance with this Agreement and/or the Venture Loan Agreement);
    
	
 
    	
 
    	
 
    
	
Security Documents
    	
 
    	
means any document entered into by any person   (including subsidiaries, if any) from time to time creating any Security   Interest, directly or indirectly, for the obligations of the Issuer under the   Venture Loan Agreement;
    
	
 
    	
 
    	
 
    
	
Security Interest
    	
 
    	
means any mortgage, charge, assignment, pledge,   lien, contractual right of set-off, hypothecation, encumbrance, priority or   other security interest or any 
    

 

5

 

	
 
    	
 
    	
arrangement which has substantially the same   commercial or substantive effect as the creation of security;
    
	
 
    	
 
    	
 
    
	
Subscriber(s)
    	
 
    	
means Kreos Capital V (UK) Limited any subsequent   Person(s) entered in the securities register which the Issuer under this   Agreement is required to maintain, as holder(s) of the Bonds;
    
	
 
    	
 
    	
 
    
	
Terms and Conditions of the Warrants
    	
 
    	
means the terms and conditions of the Warrants as   set forth in Schedule2.2 (b) hereof;
    
	
 
    	
 
    	
 
    
	
Tranche(s)
    	
 
    	
means (i) individually Tranche A, Tranche B,   Tranche C and Tranche D and (ii) collectively Tranches A and/or B and/or   C and/or D and/or Tranche under Article 2.6;
    
	
 
    	
 
    	
 
    
	
Tranche A
    	
 
    	
has the meaning ascribed to it in Article 2.2;
    
	
 
    	
 
    	
 
    
	
Tranche B
    	
 
    	
has the meaning ascribed to it in Article 2.3;
    
	
 
    	
 
    	
 
    
	
Tranche C
    	
 
    	
has the meaning ascribed to it in Article 2.4;
    
	
 
    	
 
    	
 
    
	
Tranche D
    	
 
    	
has the meaning ascribed to it in Article 2.5;
    
	
 
    	
 
    	
 
    
	
Warrants
    	
 
    	
means the warrants (bons de   souscription d’actions governed by the provisions of article   228-91 of the French commercial Code) issued in Euros by the chief executive   officer (directeur general) of the Issuer in   accordance with this Agreement and decisions of the board of directors (conseil d’administration) of the Issuer dated July 10th 2018 empowering the chief executive officer   (directeur general) of the Company to   negotiate and enter into a venture loan agreement of EUR 10,000,000 divided   into 4 tranches with 10% of warrants (bons de souscription   d’actions) and a pledge business division pursuant to decisions of   the Issuer’s general meeting dated June 4th 2018 empowering, through its 8th resolution, the Issuer’s board of directors   (conseil d’administration) to issue   warrants giving access to the Issuer’s capital.
    

 

1.2                     In this Agreement, except as otherwise provided or where clearly inconsistent in the light of the context:

 

(i)                           words importing the singular include the plural and vice versa;

 

(ii)                        words denoting gender include every gender;

 

(iii)                     words denoting persons include bodies corporate or unincorporate;

 

(iv)                    a section, clause, sub-clause or Appendix is to a section, clause, sub-clause or Appendix, as the case may be, of or to this Bonds Issue Agreement;

 

(v)                       any provision of a statute shall be construed as a reference to that provision as amended, modified, re-enacted or extended from time to time;

 

(vi)                    words and expressions in the French language defined in the French Commercial Code (Code de commerce) or the French Monetary and Financial Code (Code monétaire et financier) as amended shall bear the same meanings herein, and

 

(vii)                 capitalised terms not defined herein shall have the meaning given to them in the Venture Loan Agreement.

 

6

 

1.3                     The headings in this Agreement are for ease of reference only and shall not affect the construction of this Agreement.

 

1.4                     Should any conflicts occur between this Agreement and any of the Issue Documents, the Parties agree that the Venture Loan Agreement’s provisions shall prevail.

 

2.                          Issue and subscription

 

2.1                     The Bonds shall be issued, in four Tranches, by the Issuer in registered form exclusively reserved to the Subscriber, for a maximum nominal amount of ten million Euros (EUR 10,000,000), with a par value of one Euro (EUR 1.00) per Bond as decided by the Issuer’s chief executive officer (directeur general) in accordance with article L.228-40 of the French commercial Code (Code de commerce) and article L. 411-2 II 2 of the French Monetary and Financial Code (Code monétaire et financier). The Bonds will confer rights to the Subscriber and any subsequent Bondholder as from their subscription.

 

2.2                     Tranche A

 

Subscriber will subscribe to a first tranche (the “Tranche A”) of (i) two millions fifty-seven thousand five hundred twenty-three (2,057,523) Bonds and (ii) four hundred forty-two thousand four hundred seventy-seven (442,477) Bonds with Warrants attached, in one single drawdown, subject to the deliveries set forth in Article 3 of the Venture Loan Agreement, pursuant to a Drawdown Notice in accordance with the template attached as Appendix 2.2 (a) hereto. Warrants, having the characteristics described in Appendix 2.2 (b), shall be attached to the Tranche A. Upon issuance, the Warrants shall be detached from the Tranche A Bonds.

 

2.3                     Tranche B

 

Subscriber will have the possibility, at Issuer’s request, to subscribe to a second tranche (the “Tranche B”) of two million five hundred thousand (2,500,000) Bonds in one single drawdown of EUR 2,500,000, subject to the conditions precedent set forth in Article 4 of the Venture Loan Agreement pursuant to a Drawdown Notice in accordance with the template attached as Appendix 2.2 (a) hereto.

 

2.4                     Tranche C

 

Subscriber will have the possibility, at Issuer’s request, to subscribe to a third tranche (the “Tranche C”) of two million five hundred thousand (2,500,000) Bonds in one single drawdown of EUR 2,500,000, subject to the conditions precedent set forth in Article 4 of the Venture Loan Agreement pursuant to a Drawdown Notice in accordance with the template attached as Appendix 2.2 (a) hereto.

 

2.5                     Tranche D

 

Subscriber will have the possibility, at Issuer’s request, to subscribe a fourth tranche (the “Tranche D”) to two million five hundred thousand (2,500,000) Bonds in one single drawdown of EUR 2,500,000, subject to the conditions precedent set forth in Article 4 of the Venture Loan Agreement pursuant to a Drawdown Notice in accordance with the template attached as Appendix 2.2 (a) hereto.

 

2.6                     In the event one or several of the Tranches has not been drawn by Issuer during their availability period, the Issuer may defer the drawdown of one single undrawn Tranche, subject to the deliveries and conditions precedent set forth in Articles 3 and 4 of the Venture Loan Agreement, and draw such Tranche in a single drawdown, at any time from and subject to the cumulative fulfilment of such deliveries and conditions between April 1st, 2019 and June 30st, 2019, pursuant to a Drawdown Notice in accordance with the template attached as Appendix 2.2 (a) hereto.

 

7

 

2.7                     Subscription of the Bonds and Warrants will be wholly paid up by the Subscriber, by bank transfer, to the following account:

 

Banque NEUFLIZE OBC

3, avenue Hoche

75008 Paris, France

IBAN : FR76 3078 8001 0008 7421 1000 162

BIC : NSMBFRPPXXX

 

Concurrently with such transfer, the Subscriber shall send to the Issuer a subscription form in the form of Appendix 2.7 hereto.

 

3.                          Purpose of the Issue

 

3.1                     The Issuer shall apply the proceeds of Tranche A, Tranche B, Tranche C and Tranche D towards general working capital purposes, and agrees that it will not use the whole or any part of the proceeds of the Issue in contravention of any applicable law.

 

3.2                     Without prejudice to the above, the Subscriber shall not be under any obligation to concern itself with the application of the proceeds of the Issue.

 

4.                            Ranking

 

Each of the Bonds shall rank pari passu equally and rateably inter se without any discrimination or preference and as direct, unconditional, unsubordinated obligations, secured as set out in the Security Documents, being specified any existing loans between the Issuer and any Subsidiary (as defined in the Venture Loan Agreement) will be subordinated to and rank after the rights and interests created by the Issuer in favour of the Bondholder(s) under the Issue Documents.

 

5.                          Interest

 

5.1                     Interest on each drawdown under each Tranche shall accrue on the principal moneys outstanding on the relevant Bonds at a fixed interest rate of ten per cent (10.00 %) per annum, payable in cash, in a number of instalments equal to thirty six, increased by the number of Interest Periods elapsed between the First Interest Payment Date and March 31st, 2019, as set out in the payment schedule attached as Appendix 5.1, commencing with fixed interest payments until March 31st, 2019, and followed by thirty six (36) decreasing interest payments based on a 3.2001 % repayment rate on the outstanding nominal and interest, as set out in column 8 (Interest) of the payment schedule attached as Appendix 5.1.

 

5.2                     In the event that the drawdown on a Tranche is deferred in accordance with the provisions of clause 2.6, no fixed interest payments shall be due and the interest shall be payable at a fixed interest rate of ten per cent (10.00 %) per annum on thirty-six (36) decreasing interest payments based on a 3.2001 % repayment rate on the outstanding nominal and interest, as set out in column 8 (Interest) of the payment schedule attached as Appendix 5.1. starting on the First Interest Payment Date pertaining to such deferred Tranche.

 

5.3                     In both of the situations set out in clause 5.1 and 5.2, in the event any amount is drawn prior to the first day of any month, interest shall accrue on moneys outstanding as of their effective transfer date to Issuer until the First Interest Payment date (on the basis of a daily 1/30th of the monthly fixed interest payment set out in clause 5.1) and shall be paid by way of set-off with the funds to be transferred by Subscriber to Issuer.

 

8

 

5.4                     Interest shall be paid in respect of each Interest Period on each Interest Payment Date. To the extent interest is not paid for at least one (1) year on any Interest Payment Date, further interest shall accrue on any such interest not so paid in accordance with Article 1343-2 of the French Civil Code (Code civil) at the rate specified in Article 5.7 hereunder. Interest shall be calculated on the basis of a three hundred and sixty-five (365) day year and shall be deemed to accrue on the Bonds from day to day.

 

5.5                     Each interest payment shall be made to the Subscriber(s), on each Interest Payment Date before 11.00 AM Paris time, and the Subscriber shall be deemed, for the purposes of this Agreement, to be the holder, on such date for payment of interest, of the Bonds held by him on such preceding date notwithstanding any intermediate transfer or transmission of any such Bonds.

 

5.6                     Interest on the principal moneys outstanding on any Bonds becoming liable to repayment under any provision hereof shall cease to accrue as from the due date for repayment of such principal moneys unless repayment of any such principal moneys and/or payment of any such interest is not effected in which event interest shall continue to accrue at the rate specified in Article 5.7 on the amount which remains unpaid until actual payment in full of such principal moneys and interest is made.

 

5.7                     Should the Issuer fail to pay any outstanding nominal sum (including the amount payable by Issuer under clause 10.4 of the Venture Loan Agreement) on its due date for payment under this Agreement, the Issuer shall pay interest on such sum from the due date up to the date of actual payment (as well after as before judgment) at a rate which shall be the higher of (i) three times the legal interest rate and (ii) the sum of (a) three per cent (3 %) per annum and (b) the interest rate set out under Article 5.1 above.

 

6.                          Repayment, purchase and cancellation

 

6.1                     For each Tranche, the Issuer shall repay the Bonds at their principal amount on a monthly basis, in thirty-six (36) increasing repayments, being specified that each instalment is due in advance, on each Repayment Date in accordance with the payment schedule attached as Appendix 5.1, the last repayment from the Issuer having to occur on the 35th Interest Payment Date as an effect of clause 6.5.

 

6.2                     The repayments shall be made net to Subscriber pursuant to Article 7.

 

6.3                     The Issuer shall have the right, at any time but with no less than thirty (30) days prior notice to Subscriber, to prepay or purchase the Bonds, exclusively in whole (a “Prepayment”). The Prepayment shall be equal to (i) the principal outstanding amount under the Issue, plus (ii) the sum of all interest repayments which would have been paid throughout the remainder of the term of the relevant Tranche discounted by ten percent (10.00%) per annum. A discount calculation example is attached as Appendix 6.3 hereto.

 

6.4                     Any Bonds repaid or purchased by the Issuer shall be cancelled and the Issuer shall not be entitled to keep the same alive for the purposes of re-issue or to re-issue the same.

 

6.5                     Notwithstanding any contrary provision in this Agreement, the last instalment (including principal and interest) under each Tranche shall be paid by Issuer in advance, by way of set-off with the funds to be transferred by Subscriber to Issuer on each Drawdown Date, as a deposit to be held by Subscriber and applied in or towards payment of the last monthly repayment.

 

7.                          Taxation

 

7.1                     The Subscriber being established outside the Republic of France, interest and other revenues in respect of the Bonds benefit under present law from the exemption provided for in Article 131 quarter and Article 125 A III of the French General Tax Code (Code Général des Impôts) from withholding tax. Accordingly, such payments do not give right to any tax credit under any French tax law.

 

9

 

7.2                     The Subscriber shall provide Issuer with the tax residence statement as may be required by French tax authorities in order for the Issuer to rely on the exemption mentioned in Article 7.1.

 

7.3                     Except where directly caused by the Subscriber (including the change of tax residence, absence of delivery of the tax residence statement referred to in Article 7.2), in the event that it is required that payments of principal or interest in respect of the Bonds be subject to withholding or deduction in respect of any taxes or duties whatsoever (a “Tax Deduction”), the Issuer will pay such additional amounts as may be necessary so that the Subscriber, after such withholding or deduction, receive the full amount due to the Subscriber. For that purpose, the amount of interest due to the Subscriber shall be increased in order that the net amount received by the Subscriber after the required withholding or deduction shall equal the amount that would have been received, had such withholding or deduction not been made, it being specified that no additional payment shall be made should the Subscriber benefit from a reimbursement of such Tax Deduction.  The provisions of this Article 7.3 shall not apply if (i) any regulation applicable in the country of residence of the Issuer prohibits the Issuer from assuming the charge of the Tax Deduction, and/or (ii) the Tax Deductions which represent a tax credit, or can be used as a deduction or offset against the Subscribers’ tax.

 

7.4                     However, no such additional amounts shall be payable with respect to any Bond to the Subscriber (or to a third party on behalf of the Subscriber) who is liable to such taxes or duties in respect of such Bond by reason of his having some connection with the Republic of France other than merely being the holder of the Bond — to be clarified.

 

8.                          Undertakings

 

The Issuer undertakes with the Subscriber that, from the date of this Agreement and for so long as any amount is or may be outstanding under this Agreement, it shall comply with the commitments set forth in Article 5 (Commitments) of the Venture Loan Agreement.

 

9.                          Events of default

 

Each of the following events, facts or circumstances constitutes an Event of Default:

 

9.1                     Non-payment

 

The Issuer fails, after being notified by the Subscriber, to pay in full on the due date any sum due from it under this Agreement in the currency and in the manner specified in this Agreement save where such payment is made within five (5) Business Days of the due date and such failure is solely due to an administrative or systems error in the transmission of funds;

 

9.2                     Breach of financial information obligations

 

The Issuer fails to duly perform or comply with any of the financial information obligations expressed to be assumed by it in Article 5.2 of the Venture Loan Agreement and where such non-performance or non-compliance is capable of remedy, has not been remedied within ten (10) Business Days of the notice of that breach by the Subscriber to the Issuer;

 

9.3                     Breach of other obligations

 

The Issuer fails to duly perform or comply with any other material obligation expressed to be assumed by it in any of the Issue Documents to which it is a party and where such non-performance or non-compliance, is capable of remedy, has not been remedied within ten (10) Business Days of the notice of that breach by the Subscriber to the Issuer;

 

10

 

9.4                     Breach of ranking obligations

 

The Issuer is in breach of the ranking obligations under Article 4.1.8 (Commitments) of the Venture Loan Agreement and/or Article 4 (ranking) of this Agreement.

 

9.5                   Cross-default

 

Any indebtedness of the Issuer exceeding two hundred and fifty thousand euros (€1250,000), including, but not exclusively, as a result of any loan taken out, any bond agreement entered into, or any lease agreement entered into as the lessee, is not paid when due or within any applicable grace period, any indebtedness of the Issuer is declared to be or otherwise becomes due and payable before its specified maturity as a result of an event of default, or any creditor or creditors of the Issuer become entitled to declare indebtedness of the Issuer, due and payable before its specified maturity as a result of an event of default, except where (i) such event of default results from a breach of its obligations by a business counterparty or (ii) a business counterpart is a provider of the Issuer, and the absence of payment is made in the ordinary course of business and does not exceed five (5) Business Days;

 

9.6                     Insolvency

 

If and when applicable, the Issuer is unable to pay its debts as they fall due, with its available assets (“état de cessation des paiements”) or otherwise admits its inability to pay its debts as they fall due, or commences negotiations with any one or more of its creditors with a view to the general readjustment or rescheduling of its Indebtedness, or makes a general assignment for the benefit of, or a composition with, its creditors, whether or not through the appointment of an administrator (“administrateur judiciaire” ou “liquidateur judiciaire”), in the framework of a conciliation or safeguard procedure.

 

9.7                     Cessation of business

 

If the Issuer ceases to carry on the business it carries on at the date hereof as mentioned in section (B) of the preamble hereof, or enters into any new business that is not directly related to such business;

 

9.8                     Change of control

 

Unless otherwise agreed by the Subscriber, which opinion shall be delivered within ten (10) Business Days from the receipt by the Subscriber of a notification informing him of the potential Change of Control and the circumstances thereof, there is a Change of Control of the Issuer;

 

9.9                     Validity of agreement

 

At any time any act, condition or thing required to be done, fulfilled or performed by it in order:

 

	
(i)
    	
 
    	
to enable the Issuer lawfully to enter into,   exercise its rights under or perform the obligations expressed to be assumed   by it in the Issue Documents to which it is a party;
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
to ensure that the obligations expressed to be   assumed by the Issuer in the Issue Documents to which it is a party are and   remain legal, valid and binding;
    
	
 
    	
 
    	
 
    
	
(iii)
    	
 
    	
to make the Issue Documents to which it is a party   admissible in evidence in France;
    

 

is not done, fulfilled or performed within any time available to ensure compliance with the same;

 

11

 

9.10              Unlawfulness

 

If, at any time it is or becomes unlawful for the Issuer to perform or comply with any or all of its material obligations under the Issue Documents or if any of the material obligations of the Issuer under the Issue Documents are not, or cease to be, legal, valid and binding;

 

9.11              Material adverse change

 

The occurrence of any facts, circumstances event which have or which can reasonably be considered as likely to have a Material Adverse Effect (including (i) any payment default or event or circumstance occurs which, with the giving of notice, lapse of time, determination of materiality, the fulfillment of any other applicable condition or any combination of the foregoing constitutes a default (howsoever described) under any contract (including, without limitation, any leasing contracts) to an extent or in a manner which will have or which can reasonably be considered as likely to have a Material Adverse Effect, or (ii) any litigation, arbitration or administrative proceedings are commenced which give grounds in the reasonable opinion of an independent lawyer appointed by both parties for belief that a Material Adverse Effect will result there from); it being understood that as from the day the notice of that circumstance is given by the Subscriber to the Issuer, a ten (10) Business Day period of grace during which the Subscriber does not seek the repayment of the sums owed by the Issuer under the Issue Documents nor enforce any of its Security Interest is then granted to the Issuer in order for him, or as the case may be, its shareholders, either (i) to organize the repayment of these sums or (ii) to take all necessary actions which in the sole reasonable opinion of the Subscriber are of nature to enable the Issuer to continue to perform the Agreement in all its material provisions until the Final Redemption Date;

 

9.14            Occurrence of an Event of Default

 

In case an Event of Default has occurred, or, in the event remedial periods are provided herein, is continuing after such remedial periods has elapsed, the Subscriber may notify such Event of Default to the Issuer and at its discretion, decide that all moneys outstanding under the Bonds shall become immediately repayable and all interest accrued but unpaid shall become immediately payable, together with any other sums then owed by the Issuer under any Issue Documents, subject to Subscriber (or in case of a “masse”, the Subscribers representative) giving written notice to the Issuer to that effect no sooner than five (5) Business Days from notification of the Event of Default, provided, where such Event of Default may be remedied, that has not been remedied to the reasonable satisfaction of the Subscriber.

 

10.                     Register and certificates

 

10.1              The Issuer shall at all time keep at its registered office an accurate register of the Bonds (the “Register”) in accordance with provisions of article L. 228-1 al. 6 of the French commercial Code (Code de commerce) or have such Register duly held by an authorised agent.

 

10.2              The Issuer shall at all time ensure that the Register shows in accordance with French law:

 

(i)                           All transfers, redemption and changes of ownership in respect of the Bonds;

 

(ii)                        The names and addresses of all Bondholders.

 

The Issuer shall at all time ensure that the Register is available to the Bondholders for inspection, provided that the Bondholders give the Issuer reasonable prior notice in writing.

 

12

 

10.3              Any Bondholder and any Warrant Holder shall be entitled to receive free of charge, upon written request sent to the Issuer, a securities account statements showing evidence of the ownership of the Bonds held by him and one copy of the Agreement.

 

11.                     Transmission and transfer

 

11.1              The Bonds shall not be transferrable by the Subscriber, except (i) with the prior written consent of the Issuer or (ii) to an entity controlled by the Subscriber (within the meaning of control as defined in article L. 233-3 of the French Commercial code) or (iii) as part of a transfer of the Bondholder’s global asset portfolio of securities or of the healthcare branch of such portfolio of securities. Transfers of the Bonds shall be effected by an instrument in writing in the usual common form signed by the transferor and shall be notified to the Issuer at the latest thirty (30) Business Days prior to the transmission or transfer. Such notice shall include the specific identity of the transmittee(s) or transferee(s) and, the identity of the controlling shareholder(s), and a confirmation from the transmittee(s) or transferee(s) of its adhesion to the terms of this Agreement.

 

11.2              Every instrument of transfer must be left at the Issuer’s registered office accompanied by the transfer form of the Bonds to be transferred to prove the title of the transferor or his right to transfer the Bonds and, if the instrument shall be executed by some other person on behalf of the transferor, the authority of that person so to do.

 

11.3              To be effective vis-à-vis the Issuer and third parties, any transfer of Bonds shall be registered in the Register kept by the Issuer and the transferor of any Bonds shall be deemed to be the holder of such Bonds until the name of the transferee is entered into the securities accounts in respect thereof. The Issuer shall, within ten (10) Business Days of receipt of documents reasonably necessary to effect a transfer of the Bonds, enter the name of the transferee in the Register.

 

11.4              No fee may be charged to the Subscriber upon subscription of the Bonds and in connection with the initial registration of the Bonds or other document relating to or affecting the original title to any Bonds.

 

11.5              Any transferee that becomes a Bondholder, by whatever means and for whatever reason, shall have the benefit of, and be subject to, all of the rights and obligations arising under this Agreement as regards Bonds.

 

11.6              The Bonds shall not be offered to the public for subscription or purchase and shall not be capable of being dealt in on any stock exchange and no application shall be made to any stock exchange for permission to deal in or for an official or other quotation for the Bonds.

 

12.                     Procedures for payment

 

Any principal, interest or other moneys repayable or payable hereunder on or in respect of any Bonds may be paid by transfer to the bank account designated in writing by the Subscriber.

 

At the time of Issue, this account shall be:

 

	
Bank Name:
    	
 
    	
SVB
    
	
Account Name:
    	
 
    	
Kreos Capital V (UK) Ltd
    
	
IBAN:
    	
 
    	
 
    
	
SWIFT:
    	
 
    	
 
    

 

13

 

13.                     Rights of single or multiple Bondholders and Warrant Holders

 

13.1              For as long as the Subscriber is single, it shall exercise under its own name, all rights and powers reserved by the French Commercial Code (Code de commerce) to the “Masse” under the meaning of Article L. 228-46 of the French Commercial Code (Code de commerce) and to Bondholder’s meetings notably for events referred to in Article L. 228-65 of the French commercial Code, as regards the holding of Bonds.

 

13.2              All Bonds issued after the first Tranche, if any, shall be assimilated to the Bonds of the first Tranche and the holders of such Bonds shall be regarded as Bondholder(s) within the meaning of this Agreement and the Venture Loan Agreement and shall form part of the same Masse. For the avoidance of doubt, the holder(s) of the Warrants, after they have been detached from the Bonds, shall not form part of the same Masse.

 

13.3              As soon as the Bonds are held by more than one holder, the rights of several Bondholders will be governed, in addition to this Agreement, by the provisions of the French commercial Code (Code de commerce), applicable to the Masse.

 

14.                     Remedies and waivers

 

14.1              No failure, delay or other relaxation or indulgence on the part of the Subscriber to exercise any power, right or remedy shall operate as a waiver thereof nor shall any single or partial exercise or waiver of any power, right or remedy preclude its further exercise or the exercise of any other power, right or remedy.

 

14.2              All rights of the Subscriber contained in this Agreement are in addition to all rights vested or to be vested in it pursuant to the other Issue Documents, common law or statute.

 

14.3              Each Party hereby acknowledges that the provisions of article 1195 of the French Code civil shall not apply to it with respect to its obligations under the Issue Documents and that it shall not be entitled to make any claim under article 1195 of the French Code civil.

 

15.                     Severability

 

15.1              Each of the provisions of this Agreement and any Issue Document is severable and distinct from the others and if at any time one or more of such provisions is or becomes invalid, illegal or unenforceable the validity, legality and enforceability of the remaining provisions hereof shall not in any way be affected or impaired thereby.

 

15.2              In such case, the Issuer shall do its best effort take appropriate actions to replace such provision with an economically equivalent provision which is valid, legal and enforceable, such commitment being, for the avoidance of doubt, a material commitment.

 

16.                     Notices

 

16.1              All notices, demands or other communications under or in connection with this Agreement may be given by letter, facsimile or other comparable means of communication addressed to the person at the address identified with its signature below.

 

	
To Issuer:
    	
 
    	
Biophytis S.A.
    
	
 
    	
 
    	
A l’attention de Monsieur Stanislas Veillet
    
	
 
    	
 
    	
Président Directeur Général
    
	
 
    	
 
    	
and Monsieur Jean-Christophe Montigny
    
	
 
    	
 
    	
Directeur administratif et financier
    
	
 
    	
 
    	
14, avenue de l’Opéra
    
	
 
    	
 
    	
75001 Paris
    

 

14

 

	
 
    	
 
    	
E-mail: stanislas.veillet@biophytis.com and   jc.montigny@biophytis.com
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
With copy (for information purposes) to:
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Monsieur Marc Fredj
    
	
 
    	
 
    	
Avocat associé
    
	
 
    	
 
    	
Reed Smith LLP
    
	
 
    	
 
    	
112, avenue Kléber
    
	
 
    	
 
    	
75116 Paris
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
E-mail: mfredj@reedsmith.com
    
	
 
    	
 
    	
Fax: 01.76.70.41.19
    
	
 
    	
 
    	
 
    
	
To Subscriber:
    	
 
    	
Kreos Capital V (UK) Ltd.
    
	
 
    	
 
    	
To the attention of Mr. Maurizio Petitbon
    
	
 
    	
 
    	
5th Floor, 25-28   Old Burlington Street
    
	
 
    	
 
    	
London W1S 3AN
    
	
 
    	
 
    	
United Kingdom
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Email: maurizio@kreoscapital.com
    
	
 
    	
 
    	
Fax: +44 20 7409 1034
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
With copy (for information purposes) to:
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
Monsieur Laurent Cavallier
    
	
 
    	
 
    	
Avocat associé
    
	
 
    	
 
    	
Reinhart Marville Torre
    
	
 
    	
 
    	
58, avenue Kleber
    
	
 
    	
 
    	
75116 Paris
    
	
 
    	
 
    	
 
    
	
 
    	
 
    	
E-mail: cavallier@rmt.fr
    
	
 
    	
 
    	
Fax: +33 (0)1 53 96 04 20
    

 

16.2              Any such communication will be deemed to be given as follows:

 

	
(i)
    	
 
    	
if personally delivered, at the time of delivery, as   documented by a receipt;
    
	
 
    	
 
    	
 
    
	
(ii)
    	
 
    	
if by letter, on the date entered by the addressee   on the receipt in the case of delivery by hand or on the date when delivery   is first attempted in the case of a recorded delivery letter with   acknowledgement of receipt; and
    
	
 
    	
 
    	
 
    
	
(iii)
    	
 
    	
if by facsimile transmission or comparable means of   communication during the business hours of the addressee then on the day of   transmission, otherwise on the next following Business Day.
    

 

16.3              In proving such service it shall be sufficient to prove that personal delivery was made or that such letter was properly stamped first class, addressed and delivered to the postal authorities or in the case of facsimile transmission or other comparable means of communication that a confirming hard copy was provided promptly after transmission.

 

15

 

17.                     Law and jurisdiction

 

17.1              This Agreement is governed by and shall be construed in accordance with French law.

 

17.2              Any dispute concerning the validity, interpretation or performance of this Agreement will be submitted to the Tribunal de commerce (commercial court) of Paris.

 

Executed in Paris

in two (2) originals

On September 10th, 2018

 

 

	
/s/ Stanislas Veillet
    	
 
    	
/s/ Maurizio Petitbon
    
	
Biophytis   S.A.
    	
 
    	
Kreos Capital V (UK)   Limited
    
	
Mr. Stanislas   Veillet
    	
 
    	
Mr. Maurizio Petitbon
    

 

16

 

List of Appendixes

 

	
Appendix 2.2 (a)
    	
Template Drawdown   Notice
    
	
 
    	
 
    
	
Appendix 2.2 (b)
    	
Terms and conditions of   the Warrants
    
	
 
    	
 
    
	
Appendix 2.7
    	
Template subscription   form
    
	
 
    	
 
    
	
Appendix 5.1
    	
Amortization and   repayment schedule
    
	
 
    	
 
    
	
Appendix 6.3
    	
Prepayment discount   example
    

 

17

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