Document:

Amendment to Lease Agreement

 Exhibit 10.4 
 

 
  

			
	

	  	 November 1, 2011
  

John Sharp
 Chief Financial Officer

LIGAND PHARMACEUTICALS, INC.
 11085 N. Torrey Pines Road
 San Diego, CA 92121

 

RE:    CONFIRMATION OF
SHORT-TERM LEASE EXTENSION
  
 Dear John:
  
 Please allow this
letter to serve as confirmation of a short-term extension of the lease by and between HCP TPSP, LLC (“Landlord”) and Ligand Pharmaceuticals Incorporated (“Tenant”) dated August 7, 2009 for the premises located at 11085 North
Torrey Pines Road in San Diego, California (the “Lease”). The expiration date of the Lease, which is presently December 31, 2011, is hereby extended to June 30, 2012 (the “Extended Term”).

 
 Prior to the start of the Extended Term, Tenant shall vacate and surrender the Third
Floor Premises (as that term is defined in the Lease) in accordance with the terms and conditions of the Lease.
  
 During the Extended Term, the following shall apply:
  

•      The Premises (as that term is defined in the Lease) shall be reduced to
consist of only the First Floor Premises (as that term is defined in the Lease).
  
 •      The Monthly Installment of the Basic Annual Rent shall be adjusted to $26,448.
  

•      Tenant’s Share (as defined in Lease Section 7.2.6) shall be
reduced to 3.49%.
  

•      Within 60 days of the commencement of the Extended Term, Landlord shall
refund to Tenant $135,085.40 of the Security Deposit under the Lease, which is a pro rata portion of the existing Security Deposit relating to the Third Floor Premises, subject to any offset rights against the Security Deposit that Landlord may have
pursuant the Lease.
  

•      In the event that Landlord requires access to the Premises in order to
prepare it for a new tenant, Landlord shall have the right to relocate Tenant, at Landlord’s sole expense, to

 November 1, 2011 

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		  	 reasonably comparable office space within the business park (including the Third Floor Premises) (the
“Relocation Premises”). The parties acknowledge (i) that reasonably-comparable office space would mean space with reasonably comparable tenant improvements as well as reasonably comparable information technology improvements and
accessibility consistent with the existing First Floor Premises, (ii) that the office space located within Third Floor Premises would satisfy the “reasonably comparable office space” standard set forth above and (iii) if the
Relocation Premises is not located within the Third Floor Premises, Landlord will provide Tenant with no less than 6 weeks notification to Tenant of the need for office relocation for Tenant to work IT infrastructure upgrades to ensure service
continuation. The square footage of the Relocation Premises shall not be less than the square footage of the First Floor Premises and in no event will Tenant’s rent be increased in the event the Relocation Premises square footage exceeds the
First Floor Premises square footage.
  
 •      Tenant shall cause (or otherwise cooperate with Landlord to cause) the permit/license for the emergency generator currently serving the Third Floor Premises to be
transferred to Landlord. Landlord will pay for any associated governmental transfer fee.

		
		  	 All other terms and conditions of the Lease shall remain in full force and effect during the Extended Term.

 
 Please do not hesitate to contact me if you have any questions. If you find the
above referenced terms acceptable, please evidence your agreement by executing below and returning a copy to me at your earliest convenience.

			
		  	Sincerely,	  	Acknowledged and Agreed:
				
		  	

	  	By:	  	 

		  	Jon Bergschneider	  		  	
					
		  	Cc:	 	HCP TPSP, LLC c/o HCP, Inc. – M. Dorris & D. Cressman	  	Title	  	 VP, FINANCE & CFO

		  		 	 HCP TPSP, LLC c/o HCP, Inc. – Legal Department (J. Park)
 Cushman Wakefield Property Management – M. Egan
	  		  	
		  		 		  	Date:	  	 11/1/11License Agreement

 EXHIBIT 10.6 
 LICENSE AGREEMENT 
 This LICENSE AGREEMENT (the
“Agreement”) is executed as of October 7, 2011 (the “Effective Date”) by and between Ligand Pharmaceuticals Incorporated, a corporation organized under the laws of Delaware and having a place of business
at 11085 North Torrey Pines Road, Suite 300, La Jolla, CA, 92037 (“Ligand”) and Chiva Pharmaceuticals, Inc. a corporation organized under the laws of the Cayman Islands whose registered office is situated at Scotia Centre,
4th Floor, P.O. Box 2804, George Town, Grand Cayman KY1-1112, Cayman Islands (“Chiva”). Ligand and Chiva are each referred to herein by name or, individually, as a “Party” or, collectively, as
“Parties.” 
 BACKGROUND 
 WHEREAS, Ligand owns or has rights under certain patent rights and know-how which relate to Fablyn (as defined below); 
 WHEREAS, Chiva desires to obtain an exclusive worldwide license under such patent rights and know-how for the development and commercialization of Fablyn as set forth herein; and 

WHEREAS, Ligand desires to grant such license to Chiva, all in accordance with the terms and conditions herein. 

NOW, THEREFORE, in consideration of the mutual covenants and agreements provided herein below and other consideration, the receipt
and sufficiency of which is hereby acknowledged, Ligand and Chiva hereby agree as follows: 
 ARTICLE 1 

DEFINITIONS 
 As used in this Agreement, capitalized terms shall have the meanings indicated in this Article 1 or as specified elsewhere in this Agreement: 

1.1 “Affiliate” means, with respect to a Person, any Person that is controlled by, controls,
or is under common control with such first Person, as the case may be. For purposes of this Section 1.1, the term “control” means (a) direct or indirect ownership of [***] or more of the voting interest in the entity in question, or [***] or
more interest in the income of the entity in question; provided, however, that if local Law requires a minimum percentage of local ownership of greater than [***], control will be established by direct or indirect beneficial ownership
of [***] of the maximum ownership percentage that may, under such local Law, be owned by foreign interests, or (b) possession, directly or indirectly, of the power to direct or cause the direction of management or policies of the entity in
question (whether through ownership of securities or other ownership interests, by contract or otherwise). 

  

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the omitted portions. 

  
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 1.2 “Chiva Indemnitees” has the meaning set forth in
Section 8.2. 
 1.3 “Claim Notice” has the meaning set forth in Section 8.3.

 1.4 “Clinical Trial” means an investigation in human subjects and/or patients intended to discover or
verify the clinical, pharmacological and/or other pharmacodynamic effects of Product, and/or to identify any adverse reactions to Product, and/or to study absorption, distribution, metabolism, and/or excretion of Product with the objective of
ascertaining its safety, activity and/or efficacy. 
 1.5 “Confidential Information” means any
information of a confidential and proprietary nature, including know-how, information, invention disclosures, patent applications, proprietary materials and/or technologies, economic information, business or research strategies, trade secrets, and
material embodiments thereof, disclosed by a Party to the other Party and characterized to the receiving Party as confidential. 

1.6 “Control” or “Controlled” means, with respect to any information, material or intellectual
property right, that a Party owns or has a license to such information, material or intellectual property right, as applicable, and has the ability to grant to the other Party access to, or a license or sublicense under, such information, material
or intellectual property right as provided under the terms of this Agreement. 
 1.7 “Develop” or
“Development” means pre-clinical and clinical research and development activities, including toxicology and other pre-clinical development efforts, stability testing, process development, formulation development, delivery system
development, quality assurance and quality control development, statistical analysis, clinical pharmacology, clinical studies (including Clinical Trials), regulatory affairs, and Regulatory Approval and clinical study regulatory activities.

 1.8 “Dispute” has the meaning set forth in Section 11.11. 

1.9 “Executive” shall mean for Ligand, the Chief Executive Officer of Ligand (or such individual’s
designee), and, for Chiva, the Chief Executive Officer of Chiva (or such individual’s designee). If either position is vacant or either position does not exist, then the person having the most nearly equivalent position (or such
individual’s designee) shall be deemed to be the Executive of the relevant Party. 
 1.10
“Fablyn” [***]. 

1.11 “Fablyn Know-How” means all Know-How Controlled by Ligand or any of its Affiliates as of the Effective Date
that is (a) necessary in connection with the making, using, selling, offering to sell, exporting and importing of Product in the Territory and (b) not included in the Fablyn Patents. 

  

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 1.12 “Fablyn Patents” means those Patents Controlled by Ligand or
any of its Affiliates listed in Schedule 1.12 attached hereto. 
 1.13 “Fablyn Technology”
means the Fablyn Know-How and the Fablyn Patents. 
 1.14 “FD&C Act” means the U.S. Federal Food,
Drug, and Cosmetic Act (21 U.S.C. §301, et seq.), including any amendments or supplements thereto. 
 1.15
“FDA” means the U.S. Food and Drug Administration, or any successor agency thereto. 
 1.16
“Field” means the treatment or prevention of human diseases. 
 1.17 “First Commercial
Sale” means the first sale of Product by Chiva or its Affiliates or sublicensees to a Third Party for which payment (cash or non-cash) has been received in any country in the Territory. 

1.18 “Governmental Entity” means any regional, central, federal, state, provincial or local court, commission or
governmental, regulatory or administrative body, board, bureau, agency, instrumentality, authority or tribunal or any subdivision thereof. 
 1.19 “Improvement” means any discovery, invention, contribution, method, finding, or improvement, whether or not patentable, and all intellectual property therein, that is
conceived, reduced to practice, or otherwise developed by or on behalf of a Party, during the Term, that is a modification, improvement or enhancement to the Fablyn Patents and is dominated by the claims of one or more of the patent rights described
in Section 1.12. 
 1.20 “IND” means an Investigational New Drug application, Clinical Study
Application, Clinical Trial Exemption, or similar application or submission for approval to conduct human clinical investigations filed with or submitted to a Regulatory Authority in the applicable jurisdiction in conformance with the requirements
of such Regulatory Authority. 
 1.21 “Intellectual Property Rights” means Patents, copyrights, trade
secrets, database rights, proprietary know-how and similar rights of any type (excluding trademarks) under the laws of any Governmental Entity, including all applications, registrations, extensions and renewals relating to any of the foregoing.

 1.22 “Know-How” means all technical information and other technical subject matter, proprietary
methods, ideas, concepts, formulations, discoveries, inventions, devices, technology, trade secrets, compositions, designs, formulae, know-how, show-how, specifications, drawings, techniques, results, data, processes, methods, procedures and/or
designs, whether or not patentable. 
 1.23 “Law” means, individually and collectively, any and all
laws, ordinances, orders, rules, rulings, directives and regulations of any kind whatsoever of any Governmental Entity or Regulatory Authority within the applicable jurisdiction. 

1.24 “Ligand Indemnitees” has the meaning set forth in Section 8.1. 

  
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 1.25 “Major European Market” means the European Union as a whole or
any one of the following countries: the United Kingdom, France, Germany, Italy and Spain (or, for patent purposes, the European Patent Office). 
 1.26 “Major Market” means each of the United States, Japan and Major European Market. 
 1.27 “NDA” means a “New Drug Application,” as defined in the FD&C Act and applicable regulations promulgated thereunder by the FDA and all amendments and supplements
thereto filed with the FDA, or the equivalent application filed with any Regulatory Authority, including all documents, data, and other information concerning Product which are necessary for gaining Regulatory Approval to market and sell Product in
the relevant jurisdiction. 
 1.28 “Net Sales” means gross amounts invoiced by or on
behalf of Chiva and any of its Affiliates or sublicensees for Product sold to Third Parties who are not Affiliates or sublicensees of Chiva, unless such Affiliate or sublicensee is the end user of Product, in which case the amount billed therefor
shall be deemed to be the amount that would be billed to a Third Party end user in bona fide, arms-length transactions, less the following deductions, as determined in accordance with Chiva’s usual and customary accounting methods, which are in
accordance with United States GAAP (as generally and consistently applied throughout Chiva’s organization) to the extent included in the gross invoiced sales price of Product or otherwise directly paid or incurred by Chiva, its Affiliates or
sublicensees with respect to the sale of Product:
[***]; and [***] to the extent such amounts are [***] listed above and are
[***]. 
 1.29 “Patents” means all: (a) United States and foreign patents, re-examinations,
reissues, renewals, extensions and term restorations, inventors’ certificates and counterparts thereof; and (b) pending applications for United States and foreign patents, including, without limitation, provisional applications,
continuations, continued prosecution, divisional and substitute applications, and counterparts thereof. 
 1.30
“Person” means any individual, corporation, partnership, association, joint-stock company, trust, unincorporated organization or government or political subdivision thereof. 

1.31 [***] means the [***] by and between Ligand and [***]. 

1.32 “Product” means any product intended for use in the Field that contains Fablyn, whether alone or in
combination with other active pharmaceutical ingredients. 
 1.33 “Prosecute” or
“Prosecution” means, with respect to Patents, the filing for, prosecuting, responding to oppositions, nullity actions, re-examinations, revocation actions and similar proceedings (including without limitation conducting or
participating in interference and oppositions) filed by Third Parties against, and maintaining, Patents. 
 1.34
“Regulatory Approval” means, with respect to a country or jurisdiction within the Territory, (i) any approvals, licenses, registrations or authorizations necessary for the manufacture, marketing and sale of a Product in such
country or jurisdiction, and (ii) where relevant, pricing approvals necessary to obtain reimbursement from a Governmental Entity with respect to a Product in such country or jurisdiction. 

  

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 1.35 “Regulatory Authority” means any national (e.g., the FDA),
supranational (e.g., the EMEA), regional, state or local regulatory agency, department bureau, commission, council or other Governmental Entity in any jurisdiction of the world involved in the granting of Regulatory Approval for pharmaceutical
products. 
 1.36 “Regulatory Documentation” means all submissions to Regulatory Authorities and other
Governmental Entities, including for Clinical Trials, preclinical trials, tests, and biostudies, relating to a Product, including all INDs, NDAs and Regulatory Approvals, as well as all correspondence with Governmental Entities (registration and
licenses, pricing and reimbursement correspondence, regulatory drug lists, advertising and promotion documents), adverse event files, complaint files, manufacturing records and inspection reports. 

1.37 “Research Plan” has the meaning set forth in Section 4.2(a). 

1.38 “Sublicense Agreement” has the meaning set forth in Section 2.3. 

1.39 “Term” has the meaning set forth in Section 10.1. 

1.40 “Territory” means all of the countries in the world, and their territories and possessions. 

1.41 “Third Party” means any Person other than Ligand, Chiva or any Affiliate of either Ligand or Chiva.

 1.42 “Valid Claim” means (a) any claim of an issued and unexpired patent within the Fablyn
Patents that has not been held unenforceable or invalid by a court or other governmental agency of competent jurisdiction in a decision that is not appealed or is unappealable, and which patent has not been disclaimed or admitted to be invalid or
unenforceable through reissue or otherwise, or (b) a pending claim in a pending patent application within the Fablyn Patents that has not been abandoned, finally rejected, or expired without the possibility of appeal or refilling. 

1.43 Unless the context of this Agreement otherwise requires: (a) words of any gender include each other gender;
(b) words using the singular or plural number also include the plural or singular number, respectively; (c) the terms “hereof,” “herein,” “hereby” and derivative or similar words refer to this entire
Agreement; (d) the terms “Article,” “Section” or “Exhibit” refer to the specified Article, Section or Exhibit of this Agreement; (e) the term “or” has, except where otherwise indicated, the inclusive
meaning represented by the phrase, “and/or”; and (f) the term “including” means “including without limitation.” Whenever this Agreement refers to a number of days, such number shall refer to calendar days.

  
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 ARTICLE 2 
 LICENSES AND TECHNOLOGY TRANSFER 
 2.1 Exclusive
License for the Products. During the Term, subject to the terms and conditions of this Agreement and the
[***], Ligand hereby grants to Chiva and its Affiliates an exclusive,
royalty-bearing right and license under the Fablyn Technology to make, have made, use, sell, have sold, import and export Products in the Field in the Territory. For clarity, in the foregoing sentence, “exclusive” means that Licensor shall
not for its own account, and shall not grant to any third party the right and license under the Fablyn Technology to make, have made, use, sell, have sold, import and export Products in the Field in the Territory. Chiva acknowledges the rights
retained by [***]. 
 2.2 Rights to Improvements.  

(a) Chiva and its sublicensees shall have a right to make Improvements to the Fablyn Technology, and to utilize such Improvements
to make, have made, use, sell, have sold and import Products in the Territory. 
 2.3
Sublicenses. The rights and licenses granted pursuant to Section 2.1, include the right to grant sublicenses pursuant to a written sublicense agreement (each a “Sublicense Agreement”); provided,
however, that (i) any such Sublicense Agreement shall be consistent with and subject to the terms and conditions of this Agreement; (ii) Chiva shall remain fully responsible to Ligand for the performance of its sublicensee(s);
(iii) Chiva shall reserve the right under each Sublicense Agreement to conduct an audit of its sublicensee in a comparable manner to Section 3.9 of this Agreement; (v) Chiva shall provide a complete, executed copy of any
Sublicense Agreement within [***] of execution thereof; (v) each sublicense granted by Chiva shall terminate no later than termination of this Agreement, unless otherwise agreed by the Parties; and (vi) each sublicense granted pursuant to
any Sublicense Agreement shall be subordinate to the
[***]. Chiva shall remain obligated to make all payments
due to Ligand under the terms of this Agreement with respect to the activities of its sublicensees. 
 2.4 Technology
Transfer. Within [***] after the Effective Date, to the extent not previously provided to Chiva or otherwise in Chiva’s possession, Ligand shall use commercially reasonable efforts to disclose and provide to Chiva essential or necessary
Fablyn Technology and Regulatory Documentation critical to or necessary for making or using Products in existence and reasonably available to Ligand as of the Effective Date. Following such [***] period, Ligand shall reasonably consider any
commercially reasonable request by Chiva to disclose and provide additional essential or necessary Fablyn Technology and Regulatory Documentation critical to or necessary for making or using Products in existence and reasonably available to Ligand
as of the Effective Date. For clarity, Chiva and its European affiliates or partners will be solely responsible for the transfer of European Regulatory Documentation from [***] and be fully accountable for addressing any and all post-approval
obligations from regulatory agencies worldwide. For the avoidance of doubt, Chiva shall pay all costs and expenses related to the Fablyn program that are associated with such Technology Transfer, including all such costs and expenses associated with
transfer of Fablyn Technology and Regulatory Documentation. 

  

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 2.5 No Other Rights. Ligand and Chiva each acknowledges and agrees that,
except as expressly granted under this Agreement, no right, title, or interest of any nature whatsoever is granted whether by implication, estoppel, reliance, or otherwise, by either Party to the other Party. All rights with respect to technology,
Patents or other Intellectual Property Rights that are not specifically granted herein are reserved. 
 2.6
Bankruptcy. All rights and licenses granted under or pursuant to this Agreement, including amendments hereto, are, for all purposes of 11 U.S.C. § 365(n), licenses of rights to intellectual property as defined in the United States
Bankruptcy Code, and any comparable Law of a relevant jurisdiction. Each Party may elect to retain and may fully exercise all of its rights and elections under 11 U.S.C. § 365(n). 

ARTICLE 3 

COMPENSATION 
 3.1 License Issuance Fee. In partial consideration of the rights and licenses granted by Ligand hereunder, Chiva shall pay a one-time, non-refundable and non-creditable license issuance fee
of four million U.S. Dollars (U.S. $4,000,000) in three installments: a first payment of five hundred thousand U.S. Dollars (U.S. $500,000) within [***] of the Effective Date, a second payment of two million U.S. Dollars (U.S.$2,000,000) on or before December 1st, 2011, and a third and final payment of one million five hundred
thousand U.S. Dollars (U.S.$1,500,000) on or before June 1, 2012. 
 3.2 Milestone Payments. 

In further consideration of the rights and licenses granted by Ligand hereunder, Chiva shall pay to Ligand the non-refundable and
non-creditable milestone payments set forth below within [***] of the achievement by Chiva or its Affiliates or sublicensees of each of the corresponding events: 
  

			
	 Milestone
	  	 Payment

		
	First commercial sale of a Product in any European Union member country before Dec. 31, 2012	  	One million U.S. Dollars (U.S.$1,000,000)
		
	First commercial sale of a Product in Japan	  	Two million U.S. Dollars (U.S.$2,000,000)
		
	Achievement of five hundred million U.S. dollars (U.S.$500,000,000) in total cumulative Net Sales in the Territory	  	Ten million U.S. Dollars (U.S.$10,000,000)

  

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 For clarity, it is expressly agreed that the milestone payments set forth in each column
above will be payable once only for each Product to achieve the event. 
 3.3 Payment of Royalties 

(a) Royalty Rates. In further consideration of the rights and licenses granted by Ligand hereunder, Chiva shall pay to
Ligand five percent (5%) of aggregate Net Sales. If a generic version of a Product enters the market, then the royalty rate will be reduced by [***] for that Product from [***]. 

(b) Sublicensing. In the event Chiva grants a sublicense under Section 2.3 to a sublicensee to make, use,
import, sell, offer to sell, import or export a Product, such Sublicense Agreement shall require the sublicensee to account for and report its Net Sales on the same basis as if such sales were Net Sales, and Chiva shall pay royalties on such sales
as if the Net Sales of the sublicensees were Net Sales of Chiva. 
 (c) Payment of Royalties.
Chiva shall pay on a [***] basis all royalties due and
payable on Net Sales in each [***] pursuant to this Section 3.3 within [***] after the last day of each [***] in which the applicable Net Sales underlying such royalties were billed or invoiced by Chiva. 

(d) Royalty Term. The obligation of Chiva to pay royalties to Ligand under this Section 3.3 shall commence on
the date of the First Commercial Sale of a Product and continue, on a country-by-country basis and on a Product-by-Product basis, until the later of (i) expiration or other termination of all Fablyn Patents containing one or more Valid Claims
that would be infringed by the manufacture, sale, offer for sale, use or importation of such Product in such country, or (ii) ten (10) years from the First Commercial Sale of such Product in such country. Thereafter, Chiva shall have a
paid up, royalty-free license with respect to such Product in the applicable country. 
 3.4 Payment Method. All
payments made by Chiva under this Agreement shall be made in U.S. Dollars, and such payments shall be made by check or wire transfer to one or more bank accounts to be designated in writing by Ligand. 

3.5 Currency Conversion. In the event that Products are sold in currencies other than U.S. Dollars, Net Sales shall be
calculated by Chiva in accordance with U.S. generally accepted accounting principles, consistently applied. Net Sales in currencies other than U.S. Dollars shall be converted into U.S. Dollars using the average official rate of exchange for such
currencies published in The Wall Street Journal, Eastern Edition, [***]. If an exchange rate for any particular currency is not published in The Wall Street Journal, the rate of exchange to be used for such currency shall
be determined using average conversion rates published by the Bank of China or such conversion rates that generally are accepted in the industry [***]. 
 3.6 Late Payment Interest. Any payment due and payable to Ligand under the terms and conditions of this Agreement, including any royalty payment, made by Chiva after the date

  

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such payment is due and payable shall bear interest as of the day after the date such payment was due and payable and shall continue to accrue such interest until such payment is made at a rate
equal to the lesser of either (a) [***], as of the date such payment was due and payable, or (b) the maximum rate permitted by applicable Law; provided, however, that the total interest accrued shall be no greater than [***]
of the payment due and payable. 
 3.7 Records and Reports. All payments made to Ligand hereunder shall be
accompanied by a written statement setting forth in reasonable detail the calculation thereof, including, for example, in the case of royalty payments, the gross amount billed or invoiced by Chiva, its Affiliate or sublicensee for sale or other
disposition of Product on a country-by-country basis in the local currency, itemized deductions against such gross amount in accordance with Section 1.28, Net Sales on a country-by-country basis, and, if applicable, the exchange rate
utilized to convert a local currency to U.S. Dollars. Chiva shall maintain complete and accurate records sufficient to enable accurate calculation of royalties and other payments due Ligand hereunder. Such records and books of account shall be
preserved by Chiva for a period of [***] after the end of the period covered by such records and books of account, which obligation shall survive expiration or termination of this Agreement. Chiva must ensure that its sublicensees provide reports
and keep records in a manner consistent with this Section 3.7. Chiva shall provide reports received from sublicensees to Ligand with the applicable payment. 
 3.8 Taxes. Chiva may withhold from payment made to Ligand under this Agreement any income tax required to be withheld by Chiva under the laws of the country or jurisdiction where Chiva has
commercially sold Products. If any tax is withheld by Licensee, Licensee shall provide Licensor receipts or other evidence of such withholding and payment to the appropriate tax authorities on a timely basis following that tax payment. Each Party
agrees to cooperate with the other Party in claiming refunds or exemptions from such deductions or withholdings under any relevant agreement or treaty which is in effect. The Parties shall discuss applicable mechanisms for minimizing such taxes to
the extent possible in compliance with applicable law. In addition, the Parties shall cooperate in accordance with applicable law to minimize indirect taxes (such as value added tax, sales tax, consumption tax and other similar taxes) in connection
with this Agreement. 
 3.9 Audit Rights. Chiva shall permit an independent public accountant
designated by Ligand and reasonably acceptable to Chiva, to have access, no more than [***] in each [***] during the Term and no more than [***] during the [***] following the expiration or termination of this Agreement, during regular business hours and upon at least [***] written notice, to
Chiva’s records and books to the extent necessary to determine the accuracy of Net Sales reported, and payments made, by Chiva to Ligand within the [***] immediately preceding such an audit. The independent public accountant shall be under a
confidentiality obligation to Chiva to disclose to Ligand only (a) the accuracy of Net Sales reported and the basis for royalty and other payments made to Ligand under this Agreement and (b) the difference, if any, such reported and paid
amounts vary from amounts determined as a result of the audit. If such examination results in a determination that Net Sales or payments have been misstated, over or under paid amounts due shall be paid promptly to the appropriate Party. If Net
Sales are understated by greater than [***], the fees and expenses of such accountant shall be paid by Chiva; otherwise the fees and expenses of such accountant shall be paid by Ligand. All matters reviewed by such independent public accountant
shall be deemed Confidential Information of Chiva and shall subject to ARTICLE 6. 

  

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 ARTICLE 4 
 PRODUCT ACTIVITIES 
 4.1 Diligence. Chiva shall diligently Develop,
manufacture and sell Products, and shall use commercially reasonable efforts to develop markets for Products, in both cases either directly or through a sublicensee. In addition, Chiva, either directly or through a sublicensee, shall achieve the
events described in Schedule 4.1 within the time periods set forth in Schedule 4.1. Chiva, either directly or through a sublicensee, shall obtain all necessary Regulatory Approvals in each country where Products are made,
used, sold, imported, or offered for sale. Ligand may terminate the license for each specific territory listed in Schedule 4.1 in accordance with Section 10.2(b) if Chiva (i) fails to achieve the milestone in that
territory by the milestone achievement date as set out in Schedule 4.1 (or such later date as may be agreed by the Parties in writing) or (ii) has not sold Product for any [***] after Chiva’s First Commercial Sale of a
Product 
 4.2 Research Plan; Progress Reports. 

(a) Chiva shall develop a research plan detailing the work it will perform and associated timelines to Develop
Products and to obtain Regulatory Approval and sell Products (the “Research Plan”). Chiva will provide a copy of the Research Plan to Ligand within [***] of the Effective Date and any updates as these become available from time to time. 

(b) By [***] and [***] of each year, Chiva shall submit a written report to Ligand covering the preceding [***] period. Each
report will describe: Chiva’s progress in accordance with the Research Plan and towards commercialization of Products, including work completed, key scientific discoveries, summary of work-in-progress, current schedules or anticipated events or
milestones, market plans for introduction of Product, and significant corporate transaction(s) involving Products. Chiva shall also provide to Ligand copies of any reports received from its sublicensees, within [***] of receipt. 

  

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 4.3 Regulatory Responsibilities. 

(a) The Parties shall meet periodically as needed to discuss the regulatory plans and strategies for Products in the Field in the
Territory. Ligand has the rights to request copies of Regulatory Documentation and significant correspondence to and from all Regulatory Authorities Controlled by Chiva related to Products in the Field in the Territory. Each Party shall provide the
other Party with reasonable cooperation and assistance in connection with regulatory activities for Products in the Field in the Territory, including responding to reasonable requests by the other Party for additional Regulatory Documentation (and
information and clinical data contained therein) related to Products. 
 (b) To the extent permitted by the applicable
Regulatory Authority, Chiva shall allow representatives of Ligand to participate in any material scheduled conference calls and meetings between Chiva and the Regulatory Authority. If Ligand elects not to participate in such calls or meetings, Chiva
shall keep Ligand reasonably apprised of the discussions between Chiva and the Regulatory Authority that take place during such calls or meetings. 
 (c) Chiva shall be responsible for ensuring, at its sole expense, that the Development and commercialization of all Products in the applicable jurisdiction within the Territory are in compliance
with applicable Laws in all material respects, including all rules and regulations promulgated by applicable Regulatory Authorities. Specifically and without limiting the foregoing, Chiva shall file all compliance filings, certificates and safety
reporting for the Products at its sole expense in its applicable Territory. 

  
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 ARTICLE 5 
 INTELLECTUAL PROPERTY 
 5.1 Patent Maintenance and Prosecution.

 (a) [***] Prosecute the Fablyn Patents that are Controlled by Ligand; provided, however, Ligand shall make available to
Chiva copies of material correspondence with any patent office regarding the Fablyn Patents to the extent they relate to Products. Chiva shall have the right to comment upon the Prosecution of the Fablyn Patents, and Ligand shall reasonably consider
any such comments. Chiva shall reimburse Ligand for all reasonable costs associated with the Prosecution of the Fablyn Patents. In the event that Ligand decides to cease activities relating to Prosecuting any Fablyn Patents, Ligand shall provide
written notice thereof to Chiva and, prior to taking action that would result in the abandonment of any such Patent, Ligand shall engage in good faith discussions with Chiva, such discussions to occur at least [***] prior to the date when government
rights would be lost as a consequence of abandonment of such Patent. 
 (b) Chiva shall, at Chiva’s sole cost and
expense, and in its sole discretion, Prosecute any Patents covering Improvements. In the event that Chiva decides to cease activities relating to Prosecuting any such Patents, Chiva shall provide written notice thereof to Ligand and, prior to taking
action that would result in the abandonment of any Patent covering such Improvement, Chiva shall engage in good faith discussions with Ligand, such discussions to occur at least [***] prior to the date when government rights would be lost as a
consequence of abandonment of such Patent. 
 5.2 Fablyn Patent and Fablyn Know-How Enforcement and Defense. 

(a) Notification. Each Party shall notify the other Party of any infringement of any of the Fablyn Patents or
misappropriation of any of the Fablyn Know-How by a Third Party in the Field which becomes known to such Party, and of any claim of infringement by a Third Party that the activities of a Party infringe patent rights or misappropriate other
Intellectual Property Rights of such Third Party. 
 (b) Fablyn Patents. As between the Parties, Ligand shall have
the first right, but not an obligation, to initiate, maintain and control, at Ligand’s expense, legal action against any infringement of the Fablyn Patents by a Third Party in the Field. In the event that Ligand initiates legal action against
infringement of the Fablyn Patents by a Third Party, Ligand shall notify Chiva in writing. Thereafter, Chiva shall have a right, in Chiva’s sole discretion and, notwithstanding Section 5.3, at Chiva’s expense, to join or
otherwise participate or not to join or otherwise participate in such legal action with legal counsel selected by Chiva. Any recovery received by Ligand from legal action initiated pursuant to this Section 5.2(b), whether by judgment,
award, decree or settlement, shall be used first to reimburse Ligand for Ligand’s out-of-pocket costs and expenses actually incurred in pursuing such legal action, and second to reimburse Chiva for Chiva’s costs and expenses actually
incurred in connection with such legal action. The remainder of any recovery or distribution received by Ligand under this Section 5.2(b), after reimbursement of costs and expenses of Ligand and Chiva, shall be [***]. 

  

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 5.3 Cooperation. In any suit, proceeding or dispute
involving the infringement of any of the Fablyn Patents in the Field or misappropriation of any of the Fablyn Know-How in the Field, the Parties shall provide each other with reasonable cooperation, and, upon the request and at the expense of the
Party bringing suit, the other Party shall make available to the Party bringing suit, at reasonable times and under appropriate conditions, all relevant personnel, records, papers, information, samples, specimens, and the like in its possession.
Notwithstanding any other provision of this ARTICLE 5, [***]. 

ARTICLE 6 

CONFIDENTIALITY 
 6.1 Confidentiality Obligations. Each Party agrees that, during the Term and for [***] thereafter, all Confidential Information of the other Party shall be maintained in strict confidence,
and shall not be used for any purpose other than the purposes expressly permitted by this Agreement, and, subject to Section 6.2, shall not be disclosed to any Third Party. The foregoing obligations will not apply to any portion of
Confidential Information to the extent that it can be established by competent proof that such portion: 
 (a) was
already known to the recipient as evidenced by its written records, other than under an obligation of confidentiality, at the time of disclosure; 
 (b) was generally available to the public or was otherwise part of the public domain at the time of its disclosure to the recipient; 

(c) became generally available to the public or otherwise becomes part of the public domain after its disclosure and other than
through any act or omission of the recipient in breach of this Agreement; or 
 (d) was subsequently lawfully disclosed
to the recipient by a Third Party other than in contravention of a confidentiality obligation of such Third Party to the disclosing party. 
 6.2 Permitted Usage. Each Party may use and disclose Confidential Information of the other Party, in accordance with this Agreement, as follows: (a) under appropriate
confidentiality provisions no less restrictive than those in this Agreement, in connection with the performance of its obligations or exercise of rights granted to or retained by such Party; (b) in connection with the Prosecution or enforcement
of Fablyn Patents or Improvements, in accordance with this Agreement; or (c) in connection with prosecuting or defending litigation, complying with applicable governmental regulations, filing for, obtaining and maintaining Regulatory Approvals,
or as otherwise required by Law, but provided that if a Party is required by Law to make any disclosure of the other Party’s Confidential Information, it will give reasonable advance notice to the other Party of such disclosure requirement, it
will disclose only for the sole purpose of and solely to the extent required by such Law, and it will use its reasonable efforts to secure confidential treatment of such Confidential Information required to be disclosed. 

  

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 6.3 Terms of Agreement. The terms of this Agreement shall be Confidential
Information of both Parties, and subject to the terms of this ARTICLE 6. Notwithstanding the foregoing, either Party may make a disclosure of terms of this Agreement (i) to any financial advisors, accountants, potential sublicensees,
investors, or potential acquirers, (ii) if required by applicable Law, or (iii) as otherwise permitted pursuant to Section 6.4. Except as otherwise permitted for disclosures pursuant to Section 6.4, the disclosing
Party shall use all commercially reasonable efforts to preserve the confidentiality of this Agreement and the terms thereof notwithstanding any required disclosure. A Party will give the other Party written notice of any required disclosure under
(ii) above, which notice shall, to the extent reasonably practicable, be given a reasonable period of time in advance of such required disclosure. In the event either Party is required to file this Agreement with the U.S. Securities and
Exchange Commission or any comparable Chinese or other non-U.S. Governmental Entity, such Party shall apply for confidential treatment of this Agreement to the fullest extent permitted by applicable Law, shall provide the other Party a copy of the
confidential treatment request far enough in advance of its filing to give the other Party a meaningful opportunity to comment thereon, and shall incorporate in such confidential treatment request any reasonable comments of the other Party.

 6.4 Public Announcements. The Parties will mutually agree on a press release to be issued upon execution of
this Agreement or reasonably soon thereafter. Neither Party shall make any subsequent public announcement concerning this Agreement or the terms hereof not previously made public without the prior written approval of the other Party, such consent
not be unreasonably withheld or delayed by such other Party, with regard to the form, content, and precise timing of such announcement, except as may be required to be made by either Party in order to comply with applicable Law, regulations, court
orders, or tax, securities filings, financing arrangements, acquisitions, or sublicenses. Prior to any such public announcement, the Party wishing to make the announcement will submit a draft of the proposed announcement to the other Party in
sufficient time to enable such other Party to consider and comment thereon. 
 ARTICLE 7 

REPRESENTATIONS, WARRANTIES AND COVENANTS 
 7.1 General. Each Party represents and warrants to the other that: 

(a) it is duly organized and validly existing under the Law of the jurisdiction of its incorporation, and has full corporate power
and authority to enter into this Agreement and to carry out the provisions hereof; 
 (b) it is qualified to do business
and is in good standing in each jurisdiction in which it conducts business; 
 (c) it is duly authorized to execute and
deliver this Agreement and to perform its obligations hereunder, and the individual executing this Agreement on its behalf has been duly authorized to do so by all requisite corporate action; 

  
 14 

 (d) this Agreement is legally binding upon it and enforceable in accordance with its
terms and the execution, delivery and performance of this Agreement by it does not conflict with any agreement, instrument or understanding, oral or written, to which it is a party or by which it may be bound, nor violate any material Law; and

 (e) it is not aware of any action, suit or inquiry or investigation instituted by any Person which questions or
threatens the validity of this Agreement. 
 7.2 Representations and Covenants of Chiva. 

(a) Chiva has not, directly or indirectly, offered, promised, paid, authorized or given, and will not in the future, offer,
promise, pay, authorize or give, money or anything of value, directly or indirectly, to any Government Official (as defined below) or Other Covered Party (as defined below) for the purpose of: (i) influencing any act or decision of the
Government Official or Other Covered Party; (ii) inducing the Government Official or Other Covered Party to do or omit to do an act in violation of a lawful duty; (iii) securing any improper advantage; or (iv) inducing the Government
Official or Other Covered Party to influence the act or decision of a government or government instrumentality, in order to obtain or retain business, or direct business to, any person or entity, in any way related to this Agreement. 

For purposes of this Agreement: (i) “Government Official” means any official, officer, employee or representative of: (A) any
federal, state, provincial, county or municipal government or any department or agency thereof; (B) any public international organization or any department or agency thereof; or (C) any company or other entity owned or controlled by any
government; and (ii) “Other Covered Party” means any political party or party official, or any candidate for political office. 
 (b) Chiva maintains a system of internal accounting controls sufficient to provide reasonable assurances that transactions are recorded as necessary to permit preparation of financial statements in
conformity with generally accepted accounting principles and to maintain accountability for assets, including records of payments to any third parties, Government Officials and Other Covered Parties. 

(c) Anti-Corruption Compliance. 
 (1) Chiva and its Affiliates agree to comply with all applicable anti-corruption laws, including, without limitation: Foreign Corrupt Practices Act of 1977, as amended (“FCPA”); the
anti-corruption laws of China; and all laws enacted to implement the OECD Convention on Combating Bribery of Foreign Officials in International Business Transactions. 
 (2) Chiva is not aware of any Government Official or Other Covered Party having any financial interest in the subject matter of this Agreement or in any way personally benefiting, directly or indirectly,
from this Agreement. 
 (3) No political contributions or charitable donations shall be given, offered, promised or paid at the
request of any Government Official or Other Covered Party that is in any way related to this Agreement or any related activity, without Ligand’s prior written approval. 

  
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 (4) In the event that Chiva violates the FCPA, the anti-corruption laws of China or any
applicable anti-corruption law or breaches any provision in this Section, Ligand shall have the right to unilaterally terminate this Agreement. In addition, Chiva shall defend, indemnify and hold harmless Ligand from and against any and all costs,
damages, losses, liabilities, expenses, judgments, fines, settlements and any other amounts of any nature, including reasonable attorneys’ fees arising from any intentionally improper payment made in violation of the FCPA, any applicable
anti-corruption laws or this Section, with the knowledge of the Company. 
 7.3 Representations of Ligand. 

(a) Ligand is the exclusive licensee of the Fablyn Patents and Fablyn Know-How as of the Effective Date
pursuant and subject to the [***].‡‡‡‡‡ There are no adverse actions, suits, or claims
pending or to the knowledge of Ligand, threatened against Ligand in any court or by or before any governmental body or agency with respect to the Fablyn Patents and Fablyn Know-How and, to the actual knowledge of Ligand, there are no Third Party
patents which would reasonably be expected to give rise to such actions, suits or claims. 
 (b) Ligand has not initiated
or been involved in any proceedings or claims in which it alleges that any Third Party is or was infringing or misappropriating the Fablyn Technology, nor have any proceedings been threatened by Ligand, nor to the knowledge of Ligand is there any
valid basis for any such proceeding. 
 7.4 Covenants of Ligand. Ligand covenants that it will not, during the
Term, undertake any obligation, or grant any right, license, interest or lien, that conflicts with its obligations, or the rights and licenses granted to Chiva, under the terms of this Agreement, or impairs the rights granted by Ligand to Chiva
under the terms of this Agreement. 
 7.5 Disclaimer. EXCEPT AS PROVIDED IN THIS ARTICLE 7, NEITHER PARTY
MAKES ANY REPRESENTATION OR WARRANTY (EXPRESS, IMPLIED, STATUTORY OR OTHERWISE) WITH RESPECT TO THE SUBJECT MATTER OF THIS AGREEMENT, AND EACH PARTY SPECIFICALLY DISCLAIMS ANY AND ALL IMPLIED WARRANTIES OR CONDITIONS OF MERCHANTABILITY AND FITNESS
FOR A PARTICULAR PURPOSE, AND ALL WARRANTIES AND CONDITIONS OF THE VALIDITY OF THE FABLYN PATENTS OR NONINFRINGEMENT OF THIRD PARTY INTELLECTUAL PROPERTY RIGHTS. THIS SECTION 7.5 SHALL NOT BE CONSTRUED TO LIMIT EITHER PARTY’S OBLIGATIONS
UNDER ARTICLE 8. 
 ARTICLE 8 
 INDEMNIFICATION 
 8.1 Indemnification by Chiva. Chiva shall
indemnify, defend and hold Ligand and its Affiliates, agents, employees, officers, and directors (the “Ligand Indemnitees”) harmless from and against any and all liability, damage, loss, cost, or expense (including without
limitation reasonable attorneys’ fees) arising out of Third Party claims or suits related to: (a) breach by 

  

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Chiva of any of its representations, warranties, or covenants under this Agreement; (b) the negligence or willful misconduct of Chiva or its Affiliates, and its or their directors, officers,
agents, employees, or consultants; and (c) any exploitation by, or under the authority of, Chiva of the licenses granted under Section 2.1, (including by any Affiliate or sublicensee); provided, however, that
Chiva’ obligations pursuant to this Section 8.1 will not apply to the extent such claims or suits result from the negligence or willful misconduct of any of the Ligand Indemnitees or breach by Ligand of its representations,
warranties, or covenants set forth in this Agreement, or to the extent that Ligand has indemnification obligations with respect to such claims or suits under Section 8.2. 

8.2 Indemnification by Ligand. Ligand shall indemnify, defend, and hold Chiva and its Affiliates, sublicensees, agents,
employees, officers, and directors (the “Chiva Indemnitees”) harmless from and against any and all liability, damage, loss, cost, or expense (including without limitation reasonable attorneys’ fees) arising out of Third Party
claims or suits related to: (a) breach by Ligand of any of its representations, warranties, or covenants under this Agreement; (b) the negligence or willful misconduct of Ligand or its Affiliates, and its or their directors, officers,
agents, employees, or consultants; provided, however, that Ligand’s obligations pursuant to this Section 8.2 will not apply to the extent such claims or suits result from the negligence or willful misconduct of any of
the Chiva Indemnitees or breach by Chiva of its representations, warranties, or covenants set forth in this Agreement, or to the extent that Chiva has indemnification obligations with respect to such claims or suits under Section 8.1.

 8.3 Procedure. As a condition to a Party’s right to receive indemnification under
Section 8.1 or Section 8.2, it shall: (a) promptly deliver notice in writing (a “Claim Notice”) to the other Party as soon as it becomes aware of a claim or suit for which indemnification may be sought
pursuant to Section 8.1 or Section 8.2 (provided that the failure to give a Claim Notice promptly shall not prejudice the rights of an indemnified Party except to the extent that the failure to give prompt notice materially
adversely affects the ability of the indemnifying Party to defend the claim or suit); (b) cooperate with the indemnifying Party in the defense of such claim or suit, at the expense of the indemnifying Party; and (c) if the indemnifying
Party confirms in writing to the indemnified Party its intention to defend such claim or suit within [***] after receipt of the Claim Notice, permit the indemnifying Party to control the defense of such claim or suit, including without limitation the right to select defense counsel; provided, however,
if the indemnifying Party fails to (i) provide such confirmation in writing within such [***] period or (ii) after providing such confirmation, diligently and reasonably defend such suit or claim at any time, the indemnifying Party’s
right to defend the claim or suit shall terminate immediately in the case of (i) and otherwise upon [***] written notice by the indemnified Party to the indemnifying Party, and the indemnified Party may assume the defense of such claim or suit
at the sole expense of the indemnifying Party but may not settle or compromise such claim or suit without the consent of the indemnifying Party, not to be unreasonably withheld or delayed. In no event, however, may the indemnifying Party compromise
or settle any claim or suit in a manner which admits fault or negligence on the part of any indemnified Party or that otherwise materially affects such indemnified Party’s rights under this Agreement or requires any payment by an indemnified
Party without the prior written consent of such indemnified Party. Except as expressly provided above, the indemnifying Party will have no liability under this ARTICLE 8 with respect to claims or suits settled or compromised without its prior
written consent. 

  

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 ARTICLE 9 
 LIMITATION OF LIABILITY 
 9.1 EXCEPT FOR ANY LIABILITY THAT IS THE
CONSEQUENCE OF WILLFUL MISCONDUCT OF A PARTY, IN NO EVENT SHALL EITHER PARTY BE LIABLE TO THE OTHER PARTY FOR ANY SPECIAL, CONSEQUENTIAL, EXEMPLARY OR INCIDENTAL DAMAGES (INCLUDING LOST OR ANTICIPATED REVENUES OR PROFITS RELATING TO THE SAME),
HOWEVER CAUSED AND ON ANY THEORY OF LIABILITY ARISING OUT OF THIS AGREEMENT, WHETHER SUCH CLAIM IS BASED ON CONTRACT, TORT (INCLUDING NEGLIGENCE) OR OTHERWISE, AND WHETHER OR NOT SUCH PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH DAMAGE. THESE
LIMITATIONS SHALL APPLY NOTWITHSTANDING ANY FAILURE OF ESSENTIAL PURPOSE OF ANY LIMITED REMEDY PROVIDED HEREIN. THIS ARTICLE 9 SHALL NOT BE CONSTRUED TO LIMIT EITHER PARTY’S OBLIGATIONS UNDER ARTICLE 8. 

ARTICLE 10 

TERM AND TERMINATION 
 10.1 Term. Unless terminated earlier pursuant to Section 10.2, the term of this Agreement shall commence on the Effective Date and continue in full force and effect until, and
terminate upon, the expiration, lapse or invalidation of the last to expire of the Fablyn Patents (the “Term”). 
 10.2 Termination. 
 (a) For Convenience.
Any provision herein notwithstanding, Chiva shall have the right to terminate this Agreement in its entirety at will upon [***] prior written notice to Ligand. 
 (b) For Material Breach. If either Party shall at any time breach any material term, condition or agreement herein, and shall fail to have initiated and actively pursued remedy of any such default
or breach within sixty (60) days after receipt of written notice thereof by the other Party, that other Party may, at its option, terminate this Agreement and revoke any rights and licenses herein. Any termination of this Agreement under this
Section 10.2(b) shall not, however, prejudice the right of the Party who terminates this Agreement to recover any payment due at the time of such cancellation, and it being understood that if within sixty (60) days after receipt of
any such notice the breaching Party shall have initiated and actively pursued remedy of its default, then the rights and licenses herein granted shall remain in force as if no breach or default had occurred on the part of the breaching Party, unless
such breach or default is not in fact remedied within sixty (60) days of such notice. 

  

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 10.3 Effect of Termination/Expiration. 

(a) Rights and Obligations Upon Expiration. Upon expiration (but not earlier termination) of this Agreement, all rights and
licenses granted by Ligand to Chiva hereunder that were in effect immediately prior to the effective date of such expiration shall become irrevocable, perpetual and fully-paid. 

(b) Rights and Obligations Upon Termination. As of the effective date of a termination (but not expiration) of this
Agreement for any reason, this Agreement and all rights and licenses granted to Chiva under Section 2.1 and any right and licenses to Improvements granted to Chiva shall terminate and all rights in the Fablyn Technology and any
Improvements shall revert or be assigned to Ligand; (ii) Chiva shall return to Ligand the Fablyn Know-How and shall transfer to Ligand all then-existing Regulatory Documentation; and (iii) each Party shall return to the other Party and
cease using all Confidential Information of the other; provided, however, each Party may retain one (1) copy of such Confidential Information for archival purposes. 

(c) Accrued Rights. Termination or expiration of this Agreement for any reason will be without prejudice to any rights that
will have accrued to the benefit of a Party prior to such termination or expiration. Such termination or expiration will not relieve a Party from accrued payment obligations or from obligations which are expressly indicated to survive termination or
expiration of this Agreement. 
 (d) Survival. All rights and obligations of the Parties which by intent or
meaning have validity beyond or by their nature apply or are to be performed or exercised after the termination or expiration of this Agreement shall survive the termination or expiration of this Agreement for the period so specified, if any, or for
perpetuity. 
 ARTICLE 11 
 GENERAL PROVISIONS 
 11.1 Entire Agreement. The
Parties acknowledge that this Agreement, together with the exhibits and schedules attached hereto, sets forth the entire agreement and understanding of the Parties as to the subject matter hereof, and supersedes all prior and contemporaneous
discussions, agreements and writings in respect hereto. No waiver, modification, amendment or alteration of any provision of this Agreement will be valid or effective unless made in writing and signed by each of the Parties. 

11.2 Modification; Waiver. This Agreement may not be altered, amended or modified in any way except by a writing signed by
both Parties. The failure of a Party to enforce any rights or provisions of the Agreement shall not be construed to be a waiver of such rights or provisions, or a waiver by such Party to thereafter enforce such rights or provisions or any other
rights or provisions hereunder. No waiver shall be effective unless made in writing and signed by the waiving Party. 

11.3 Further Assurances. Each Party agrees to execute, acknowledge, and deliver such further instruments and to do all such
other acts as may be necessary or appropriate in order to carry out the express provisions of this Agreement. 
 11.4
Force Majeure. Neither Party shall be held responsible for any delay or failure in performance hereunder caused by strikes, embargoes, unexpected government requirements, civil or military authorities, acts of God, earthquake, or by the
public enemy or other causes reasonably 

  
 19 

 
beyond such Party’s control and without such Party’s fault or negligence; provided that the affected Party notifies the unaffected Party as soon as reasonably possible, and
resumes performance hereunder as soon as reasonably possible following cessation of such force majeure event; and provided further that no such delay or failure in performance shall continue for more than [***]. In the event that a delay or failure in performance by affected Party
under this Section 11.4 continues longer than [***], then the unaffected Party may terminate this Agreement in accordance with the terms and conditions of Section 10.2(b). 

11.5 Assignments. Neither this Agreement nor any interest hereunder may be assigned, nor any other obligation delegated, by
a Party without the prior written consent of the other Party; provided, however, that a Party shall have the right to assign this Agreement without consent of the other Party to an Affiliate of the assigning Party or to any successor
in interest to the assigning Party by operation of law, merger, consolidation, or other business reorganization or the sale of all or substantially all of its assets relating to the subject matter of this Agreement in a manner such that the
assigning Party will remain liable and responsible for the performance and observance of all of its duties and obligations hereunder. This Agreement shall be binding upon successors and permitted assigns of the Parties. Any assignment not in
accordance with this Section 11.5 will be null and void. 
 11.6 Performance by Affiliates. The
Parties recognize that each may perform some or all of its obligations under this Agreement through its Affiliates or may exercise some or all of its rights under this Agreement through its Affiliates; provided, however, that each
Party shall remain responsible and be the guarantor of the performance by its Affiliates and shall cause its Affiliates to comply with the provisions of this Agreement in connection with such performance. In particular and without limitation, all
Affiliates of a Party that receive Confidential Information of the other Party pursuant to this Agreement shall be governed and bound by all obligations set forth in ARTICLE 6. Each Party will prohibit all of its Affiliates from taking any
action that such Party is prohibited from taking under this Agreement as if such Affiliates were parties to this Agreement. 

11.7 Relationship of the Parties. The Parties shall perform their obligations under this Agreement as independent
contractors and nothing in this Agreement is intended or will be deemed to constitute a partnership, agency or employer-employee relationship between the Parties. Neither Party will have any right, power or authority to assume, create, or incur any
expense, liability, or obligation, express or implied, on behalf of the other. 
 11.8 No Use of Names. Except as
otherwise required under applicable Law, or as otherwise permitted under Section 6.4, neither Party will use the name of the other Party in its advertising, press releases or promotional materials without the prior written consent of
such other Party. 
 11.9 Notices. Any notice, request, delivery, approval or consent required or permitted to be
given under this Agreement will be in writing and will be deemed to have been sufficiently given if delivered in person (in which case, it will be effective upon delivery), transmitted by facsimile (receipt verified; in which case, it will be
effective upon delivery) or by express courier 

  

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service (signature required; in which case, it will be effective two business days after being deposited with such courier service) or by registered letter, return receipt requested (or its
equivalent; in which case, it will be effective five business days after being mailed), provided, however, no postal strike or other disruption is then in effect or comes into effect within two (2) days after such mailing, to the Party
to which it is directed at its address or facsimile number shown below or such other address or facsimile number as such Party will have last given by notice to the other Party. 

 

			
	If to Ligand:	  	Ligand Pharmaceuticals Incorporated
		  	11085 North Torrey Pines Road, Suite 300
		  	La Jolla, CA, 92037
		  	Attention: General Counsel
		  	Fax: (858) 550-7272
	  
 With a copy to (which shall not
constitute notice hereunder):
  

		  	Latham & Watkins LLP
		  	12636 High Bluff Drive, Suite 400
		  	San Diego, CA, 92130
		  	Attention: Faye H. Russell, Esq.
		  	Fax: (858) 523-5450
		
	If to Chiva:	  	Chiva Pharmaceuticals, Inc.
		  	c/o 22nd Floor, Hang Lung Centre,
		  	2-20 Paterson Street, Causeway Bay,
		  	Hong Kong
		  	Attention: Legal Counsel
		  	Fax: (852) 2577 3509

 11.10 Governing Law. The rights and obligations of the Parties under this Agreement shall
be governed, and shall be interpreted, construed, and enforced, in all respects by the Law of the State of California, without giving effect to any conflict of Law rule that would result in the application of the Law of any jurisdiction other than
the internal Law of the State of California to the rights and duties of the Parties. 
 11.11 Dispute Resolution.
The Parties agree that the procedures set forth in this Section 11.11 shall be the exclusive mechanism for resolving any bona fide disputes, controversies or claims (collectively, “Disputes”) between the Parties that
arise from time to time pursuant to this Agreement relating to any Party’s rights and/or obligations hereunder that cannot be resolved through good faith negotiation between the Parties. 

(a) Executive Mediation. Any Dispute shall first be referred to an Executive from each Party for attempted resolution by
good faith negotiations. Any such Dispute shall be 

  
 21 

 
submitted to such Executives no later than [***] following
such request by either Party. Such Executives shall attempt in good faith to resolve any such Dispute within [***] after submission of the Dispute. In the event the Executives are unable to resolve the Dispute, the Parties shall otherwise negotiate
in good faith and use reasonable efforts to settle. 
 (b) Arbitration. If the Parties are not able to fully
settle a Dispute pursuant to Section 11.11(a) above, and a Party wishes to pursue the matter, each such Dispute that is not an Excluded Claim shall be finally resolved by binding arbitration in accordance with the Commercial Arbitration
Rules and Supplementary Procedures for Large Complex Disputes of the American Arbitration Association (“AAA”), and judgment on the arbitration award may be entered in any court having jurisdiction thereof. 

(1) The arbitration shall be conducted by a panel of three persons experienced in the pharmaceutical business.
Within [***] after initiation of arbitration, each Party shall select one person to act as arbitrator and the two Party-selected arbitrators shall select a third arbitrator within [***] of their appointment. If the arbitrators selected by the
Parties are unable or fail to agree upon the third arbitrator, the third arbitrator shall be appointed by the AAA. The place of arbitration shall be [***], and all proceedings and communications shall be in English. 

(2) Either Party may apply to the arbitrators for interim injunctive relief until the arbitration award is rendered or the controversy
is otherwise resolved. Either Party also may, without waiving any remedy under this Agreement, seek from any court having jurisdiction any injunctive or provisional relief necessary to protect the rights or property of that Party pending the
arbitration award. The arbitrators shall have no authority to award punitive or any other type of damages not measured by a Party’s compensatory damages. Each Party shall bear its own costs and expenses and attorneys’ fees and [***].

 (3) Except to the extent necessary to confirm an award or as may be required by Law, neither a Party nor an arbitrator may
disclose the existence, content, or results of an arbitration without the prior written consent of both Parties. In no event shall an arbitration be initiated after the date when commencement of a legal or equitable proceeding based on the dispute,
controversy or claim would be barred by the applicable California statute of limitations. 
 (c) As used in this Section,
the term “Excluded Claim” shall mean a Dispute that concerns (a) the validity or infringement of a patent, trademark or copyright; or (b) any antitrust, anti-monopoly or competition law or regulation, whether or not statutory.
For all Excluded Claims, the Parties hereby submit to the exclusive jurisdiction of the courts of the State of California, in and for the County of San Diego, or of the United States of America for the Southern District of California. 

  

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 11.12 Headings. The article, section and subsection headings contained herein
are for the purposes of convenience only and are not intended to define or limit the contents of the articles, sections or subsections to which such headings apply. 
 11.13 Severability. When possible, each provision of this Agreement will be interpreted in such manner as to be effective and valid under Law, but, if any provision of this Agreement is held
to be prohibited by or invalid under Law, such provision will be ineffective but only to the extent of such prohibition or invalidity, without invalidating the remainder of such provision or of this Agreement. The Parties will make a good faith
effort to replace the invalid or unenforceable provision with a valid one which in its economic effect is most consistent with the invalid or unenforceable provision. 
 11.14 Counterparts. This Agreement may be executed in counterparts (including by facsimile or electronic signature), each of which shall be deemed an original and all of which together shall
constitute one instrument. 
 [Signature Page Follows] 

  
 23 

 IN WITNESS WHEREOF, the Parties have executed this Agreement in duplicate originals by their
duly authorized representatives as of the Effective Date. 
  

									
	LIGAND PHARMACEUTICALS INCORPORATED	 		 	CHIVA PHARMACEUTICALS, INC.
			
	(“Ligand”)	 		 	(“Chiva”)
					
	By:	 	 /s/ Charles Berkman
	 		 	By:	 	 /s/ Zhigian (David) Xi

					
	Name:	 	 Charles Berkman
	 		 	Name:	 	 Zhigian (David) Xi

					
	Title:	 	 Vice President, General Counsel
	 		 	Title:	 	 Chief Executive Officer

					
		 	 & Secretary
	 		 		 	

 [Signature Page of License Agreement] 

 EXHIBIT A 
 Fablyn 
 [TO BE PROVIDED] 

 EXHIBIT A 
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 Schedule 1.12 
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	*** 	 Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	*** 	 Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to
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	 [***]
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	 [***]
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	 [***]
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	*** 	 Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	*** 	 Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to
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	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
								
	 [***]
	  	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  

  

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	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  

  

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	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
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	 [***]
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	*** 	 Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
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	*** 	 Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to
the omitted portions. 

  
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
								
	 [***]
	  	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
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	 [***]
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the omitted portions. 

  
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	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
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	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
	  	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	*** 	 Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to
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 56 

																											
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	*** 	 Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  

  

																											
	 [***]
	  	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 
	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
	  	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 	  	 	 
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	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	 [***]
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	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  

  

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	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
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	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  
	 [***]
	  	[***]	  	 	[***]	  	  				  				  	 	[***]	  	  	 	[***]	  	  	 	[***]	  

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 Schedule 4.1 

 

			
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	***	 Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted portions.

Source: [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00196-of-00352.parquet"}, [{"source": "alea-institute/alea-institute/kl3m-data-edgar-agreements/train-00196-of-00352.parquet"}]]