Document:

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                                                                   Exhibit 10.72

                                           ***TEXT OMITTED AND FILED SEPARATELY
                                               CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(b)(4)
                                                                  AND 240.24B-2

                                 2003 AMENDMENT
                  TO THE RENEWED DISTRIBUTORSHIP AGREEMENT AND
                   THE DISTRIBUTORSHIP ARRANGEMENTS AGREEMENT
                               DATED MAY 2ND, 1997

This amendment is entered into as of the 2nd day of May 2003 by and between
Gen-Probe Incorporated, a Delaware corporation, with its principal place of
business located at 10210 Genetic Center Drive, San Diego, California 92121
("GEN-PROBE) and bioMerieux S.A., a French corporation, having its principal
place of business at Chemin de l'Orme, 69280 Marcy L'Etoile, France
("BIOMERIEUX").

                                    RECITALS

A.    GEN-PROBE and BIOMERIEUX have entered into a Distribution Agreement and a
      Distributorship Arrangements Agreement ("the Agreements") both dated May
      2nd, 1997, under which GEN-PROBE has appointed BIOMERIEUX as its exclusive
      distributor for the sales of certain products in certain specified
      countries.

B.    The Distributorship Arrangements Agreement has been modified twice from
      its date of conclusion, by way of amendments, in order to (i) delete
      Singapore from the list of countries identified as Phase II Countries, and
      (ii) to include Poland, a Phase III Country, into the definition of the
      Territory pursuant to Section 1.5 of the Distributorship Arrangement
      Agreement.

C.    The Distribution Agreement has been modified once from its date of
      conclusion, by way of amendment dated February 2, 1998, in order to (i)
      modify the wording of Section 3.3 of the Distribution Agreement, and (ii)
      to delete Exhibit C to the Distribution Agreement.

D.    The Distribution Agreement and the Distribution Arrangements Agreement are
      sometimes collectively referred to in this Amendment as "the Distribution
      Agreements."

E.    The original term of the Distribution Agreements has been extended by a
      Renewal Amendment signed by the parties as of November 23, 1999.

F.    Gen-Probe and BIOMERIEUX have entered into a Authorized Representative
      Appointment Agreement dated July 15, 1998 in order to comply with the
      requirements of the Council Directive 93/42/EEC of June 14, 1993
      concerning medical devices and the sale of the Gen-Probe Collection Kits
      in Europe.

G.    GEN-PROBE and BIOMERIEUX have expressed their mutual interest in extending
      the Distribution Agreements and have therefore decided to enter into this
      2003 Amendment to the renewed Distribution Agreements.

                                       1
<PAGE>

                                    AMENDMENT

Now, therefore, in consideration of the mutual commitments set forth below, the
parties hereto as follows:

1.    Definitions. Capitalized terms not otherwise defined herein shall have the
      meaning ascribed to them in the Agreements.

2.    The parties hereto mutually agree to renew the Term of the Agreements for
      a further period of three (3) years, starting from May 2nd, 2003 (the
      "Renewed Term"), unless earlier terminated according to the provisions of
      the Agreements. No less than one year prior to the scheduled expiration of
      the Renewed Term, the parties shall commence good faith negotiations
      regarding another possible extension of the Renewed Term on mutually
      acceptable terms, provided that, unless the parties shall have reached
      mutual agreement on the terms and conditions of such an extension within
      six (6) months of the scheduled expiration of the Renewed Term, the
      Renewed Term shall automatically expire on the date set forth in the first
      section of this Section 2.

3.    Notwithstanding the provisions of the foregoing Paragraph 2, during the
      Renewed Term, either party may terminate the Agreements as of their
      anniversary date in any year by giving notice to the other party at least
      120 days prior to the anniversary date of an intention to terminate or
      seek amendment of the Agreements. Furthermore, during the Renewed Term of
      the Agreements, GEN-PROBE shall have the additional right and option to
      terminate the Agreements, by giving 90-days notice, if BIOMERIEUX's
      purchases of GEN-PROBE products under the Distribution Agreement during
      any period of not less than [...***...] fall [...***...] or more below
      purchases for the corresponding period of the prior year. The calculation
      of the amount of decrease in BIOMERIEUX's purchases from GEN-PROBE for
      purposes of the preceding sentence shall exclude any decline in
      BIOMERIEUX's purchases from GP due to (i) sales of APTIMA Products by
      GEN-PROBE from former customers for GP products and/or (ii) any recalls of
      product by GEN-PROBE.

4.    The Parties mutually agree to amend the Distribution Agreement with the
      updated Product list and Parts list Pricing which is attached to this
      Amendment as Attachment A.

5.    The Parties mutually agree to amend the Distribution Arrangements
      Agreement to define the Territories as those countries listed on
      Attachment B to this Amendment.

6.    As the manufacturer and as outlined in the 93/42/EEC Directive and
      98/79/EC Directive (collectively the "Directives"), Gen-Probe is aware of
      the terms of the Directives and acknowledges its obligations as the
      manufacturer for the compliance of Products which are provided to
      bioMerieux for distribution into the EEC. In conjunction with the
      Directives, Gen-Probe also warrants to provide bioMerieux the following:

      A.    Gen-Probe will provide a 6-language standard Product. Additional
            languages will be mutually discussed in the future.

      B.    Gen-Probe will provide bioMerieux with the following materials:

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       2
<PAGE>

            -     The declaration of conformity for the Products covered by the
                  Directives and any relevant updates thereof, and

            -     A copy of the safety data sheet written in English for
                  Products considered to contain a dangerous substance as
                  defined in directives 67/548/EEC and 1999/45/EC and any
                  relevant updates thereof.

      C.    Both Parties agree to authorize and conduct audits in the premises
            involved in the manufacturing, packaging, storage and shipment of
            the Products as required by the Directives.

      D.    Gen-Probe agrees to implement appropriate corrective and / or
            preventative actions for complaints relating to the Products.

7.    For the MTC-NI Product, sold into the Industrial Marketplace (Non Clinical
      sites) the Distribution rights of this Product will change from Exclusive
      to Co-Exclusive.

8.    Except as expressly modified hereby, all terms and conditions of the
      original Distribution Agreements (as previously amended) shall remain
      unchanged and in full force and effect.

AGREED TO AND ACCEPTED BY:

GEN-PROBE INCORPORATED                            BIOMERIEUX S.A.

By: /s/ Henry L. Nordhoff                         By: /s/ Benoit Adelus
    ---------------------                            -----------------
Name: Henry L. Nordhoff                           Name: Benoit Adelus
Title: President & CEO                            Title: Chief Executive Officer

                                       3
<PAGE>

                                  ATTACHMENT A
                            PRODUCT LIST WITH PRICING

<TABLE>
<CAPTION>
 CAT #                               DESCRIPTION                                     U.O.M.                   NEW PRICE
 -----                               -----------                                     ------                   ---------
<S>                 <C>                                                              <C>                   <C>
1791F               DETECTION REAGENT KIT                                             Kit                  $   [...***...]
1792F               PACE 2 CHLAMYDIA TRACHOMATIS                                      Kit                  $   [...***...]
1793F               PACE 2 NEISSERIA GONORRHOEAE                                      Kit                  $   [...***...]
2325F               STD PROFICIENCY PANEL, 3 VIALS/BOX                                Kit                  $   [...***...]
2930F               FAST EXPRESS REAGENT KIT                                          Kit                  $   [...***...]
3275F               MALE COLLECTION KITS                                              Kit                  $   [...***...]
3300F               FEMALE COLLECTION KITS                                            Kit                  $   [...***...]
3548F               PACE 2 C. TRACHOMATIS PROBE COMPETITION ASSAY                     Kit                  $   [...***...]
3549F               PACE 2 N. GONORRHOEAE PROBE COMPETITION ASSAY                     Kit                  $   [...***...]
3905F               PACE 2C FOR C. TRACHOMATIS & N. GONORRHOEAE                       Kit                  $   [...***...]
1001F               AMPLIFIED M. TUBERCULOSIS DIRECT                                  Kit                  $   [...***...]
1043F               MTD CONTROLS                                                      Kit                  $   [...***...]
LR0019F             MTD NEG. CONTROL                                                  Each                 $   [...***...]
LR0030F             MTD POS. CONTROL                                                  Each                 $   [...***...]
3890F               GROUP A STREPTOCOCCUS DIRECT                                      Kit                  $   [...***...]
4573F               MYCOPLASMA T.C. NON-ISOTOPIC (MTC-NI)                             Kit                  $   [...***...]
301012F             AMPLIFIED CHLAMYDIA TRACHOMATIS                                   Kit                  $   [...***...]
301015F             SWAB PROCESS, AMPLIFIED CT                                        Kit                  $   [...***...]
301016F             URINE PROCESS, AMPLIFIED CT                                       Kit                  $   [...***...]
2810F               ACCUPROBE CAMPYLOBACTER                                           Kit                  $   [...***...]
2815F               ACCUPROBE ENTEROCOCCUS                                            Kit                  $   [...***...]
2820F               ACCUPROBE GROUP B STREPTOCOCCUS                                   Kit                  $   [...***...]
2825F               ACCUPROBE HAEMOPHILUS INFLUENZAE                                  Kit                  $   [...***...]
2830F               ACCUPROBE NEISSERIA GONORRHOEAE                                   Kit                  $   [...***...]
2865F               ACCUPROBE STREPTOCOCCUS PNEUMONIAE                                Kit                  $   [...***...]
2875F               ACCUPROBE STAPHYLOCOCCUS AUREUS                                   Kit                  $   [...***...]
2920F               ACCUPROBE LISTERIA MONOCYTOGENES                                  Kit                  $   [...***...]
2925F               ACCUPROBE GROUP A STREPTOCOCCUS                                   Kit                  $   [...***...]
2800F               ACCUPROBE GENERIC REAGENT KIT                                     Kit                  $   [...***...]
2890F               ACCUPROBE BLASTOMYCES DERMATITIDIS                                Kit                  $   [...***...]
2895F               ACCUPROBE COCCIDIOIDES IMMITIS                                    Kit                  $   [...***...]
2910F               ACCUPROBE HISTOPLASMA CAPSULATUM                                  Kit                  $   [...***...]
2835F               ACCUPROBE MYCOBACTERIUM AVIUM                                     Kit                  $   [...***...]
2840F               ACCUPROBE M. INTRACELLULARE                                       Kit                  $   [...***...]
2845F               ACCUPROBE M. AVIUM COMPLEX                                        Kit                  $   [...***...]
2850F               ACCUPROBE MYCOBACTERIUM GORDONAE                                  Kit                  $   [...***...]
2855F               ACCUPROBE MYCOBACTERIUM KANSASII                                  Kit                  $   [...***...]
2860F               ACCUPROBE M TUBERCULOSIS COMPLEX                                  Kit                  $   [...***...]
2775F               GEN-PROBE HEAT BATH (20 tube capacity)                            Each                 $   [...***...]
3100i               LEADER(R) 50i                                                     Each                 $   [...***...]
4006                GEN-PROBE HEAT BATH (50 tube capacity)                            Each                 $   [...***...]
1639F               PACE(R) MAGNETIC SEPARATION UNIT (80 tube capacity)               Each                 $   [...***...]
1714                BOTTLE TOP DISPENSER (2mL)                                        Each                 $   [...***...]
1847F               LEADER(R) PRINTER PAPER (1 roll/pack)                             Package              $   [...***...]
</TABLE>
                                               *CONFIDENTIAL TREATMENT REQUESTED

<PAGE>

<TABLE>
<CAPTION>
 CAT #                                       DESCRIPTION                             U.O.M.                   NEW PRICE
 -----                                       -----------                             ------                   ---------
<S>                 <C>                                                              <C>                   <C>
2065F               PACE(R) REACTION TUBES (120 tubes/box)                            Box                  $   [...***...]
2085F               PACE(R) SEALING CARDS (35/pack)                                   Package              $   [...***...]
2113                EPPENDORF REPEAT PIPETTOR                                         Each                 $   [...***...]
2168F               TRITIUM STANDARD                                                  Each                 $   [...***...]
2440F               POLYPROPYLENE TUBES (250 tubes/pack)                              Package              $   [...***...]
2775A               HEATING BLOCK INSERT (20 tube capacity)                           Each                 $   [...***...]
3078                BOTTLE TOP DISPENSER (5mL)                                        Each                 $   [...***...]
3919                WASH BOTTLE & CAP ASSEMBLY (200 ml capacity)                      Each                 $   [...***...]
3994F               50-WELL STRIP RACK SYSTEM (50 tubes)                              Each                 $   [...***...]
4008                BLUE SNAP CAPS (150/package)                                      Package              $   [...***...]
4027F               SONICATOR RACK (50 hole)                                          Each                 $   [...***...]
4085F               PLUGGED PIPETTE TIPS (175 mL - 1 case, 6 boxes/case, 120/box)     Case                 $   [...***...]
4224F               PLUGGED PIPET TIPS, EXT. LENGTH 250 mL (6 boxes/case)             Case                 $   [...***...]
4316F               PLUGGED PIPET TIPS, 1250 mL (6 boxes/case)                        Case                 $   [...***...]
1042F               LDR CHECK-D                                                       Each                 $   [...***...]
</TABLE>

                                               *CONFIDENTIAL TREATMENT REQUESTED

<PAGE>

                                  ATTACHMENT B
                        TERRITORIES COVERED BY BIOMERIEUX

EUROPE :

France (Oct 97)
Germany (Jan 98)
Italy (Feb 98)
Spain (Jan 98)
UK (Jan 98)
Ireland (sales made through UK) (Jan 99)
Portugal (Jan 98)
Greece (June 98)
Switzerland (Jan 98)
Belgium (Jan 98)
Luxembourg (sales made through Belgium) (Jan 98)
The Netherlands (Jan 98)

Austria (Jan 98)
Czech Republic (Sales made through Austria) (Jan 98)
Hungary (Sales made through Austria) (Jan 98)
Slovakia (Sales made through Austria) (Jan 98)
Romania
Tunisia
Croatia (Sales made through A&B) (Jan 98)
Macedonia (Sales made through Avicena) (April 00)
Slovenia (Sales made through Mikro-polo) (Jan 98)
Poland (Oct 98) Liechtenstein (Sales made through Switzerland)
Malta (Jan 98)
Iceland

LATIN AMERICA :

Argentina (June 99)
Columbia
Mexico (Jan 00)

ASIA & PACIFIC :

Australia (Jan 98)
New Zealand (sales made through Australia) (Jan 99)
China (Jan 01)
Taiwan (March 03)
India (May 00)<PAGE>

                                                                   Exhibit 10.73

                                            ***TEXT OMITTED AND FILED SEPARATELY
                                                CONFIDENTIAL TREATMENT REQUESTED
                                           UNDER 17 C.F.R. SECTIONS 200.80(b)(4)
                                                                   AND 240.24B-2

                                SUPPLY AGREEMENT

This Supply Agreement ("Agreement") is entered into this 1st day of January,
2002 ("Effective Date") by and between:

GEN-PROBE INCORPORATED, a Delaware corporation, with its principal place of
business at 10210 Genetic Center Drive, San Diego, California 92121-4362
("Gen-Probe") and

MGM INSTRUMENTS, INC., a Nevada corporation, with its principal place of
business at 925 Sherman Avenue, Hamden, Connecticut 06514 ("MGM").

                                    RECITALS

      WHEREAS, Gen-Probe is in the business of developing, marketing, and
selling medical diagnostic products;

      WHEREAS, MGM is in the business of manufacturing and selling medical
diagnostics instrumentation devices;

      WHEREAS, Gen-Probe desires to have MGM manufacture and supply certain
medical diagnostics instrumentation devices to Gen-Probe for sale or lease to
Gen-Probe's customers; and

      WHEREAS, MGM is willing to manufacture and supply such medical diagnostics
instrumentation devices to Gen-Probe according to the terms and conditions
hereinafter set forth;

      NOW THEREFORE, in consideration of the mutual covenants contained herein,
Gen-Probe and MGM agree as follows:

1.    DEFINITIONS

      1.1 "ATP" shall mean the final Acceptance Test Procedures for the
commercial production of the Instruments, referenced in Exhibit A, attached
hereto and incorporated by reference herein, as they may be modified from time
to time in accordance with Article 3 of this Agreement.

      1.2 "Decontamination Procedures" shall mean the cleaning procedures to be
used prior to the return of an instrument to MGM, attached hereto as Exhibit F
and incorporated by reference herein.

      1.3 "Instrument" or "Instruments" shall mean those items identified in
Exhibit C, which is attached hereto and incorporated by reference herein.

      1.4 "Specifications" shall mean the specifications and drawings of the
Instruments provided by Gen-Probe as they may be modified from time to time in
accordance with Article 3 of this Agreement.

                                       1
<PAGE>

      1.5 "Supply Term" shall have the meaning set forth in Section 4.1.

      1.6 "Warranty Period" shall have the meaning set forth in Section 10.3(a).

2.    SCOPE OF WORK TO BE PERFORMED BY MGM AND GEN-PROBE

      2.1 MGM shall manufacture, supply, and deliver the Instruments and Parts,
as defined below, in accordance with the terms of this Agreement and in
accordance with the Specifications.

      2.2 Gen-Probe may purchase spare parts listed on Exhibit E, attached
hereto and incorporated by reference herein (collectively, "Parts"), and
Instruments from MGM under this Agreement and then resell, rent, lease, or
otherwise dispose of such Instruments and Parts to users and distributors.

3.    MODIFICATIONS TO SPECIFICATIONS AND TESTING PROCEDURES

      3.1 During the term of this Agreement, either party can propose changes to
the Specifications and ATP which may enhance the Instrument's performance or
reliability, or may make it easier or more economical to manufacture, handle or
repair, or which otherwise may be an improvement thereof. Such proposals shall
be made in writing describing the change in detail and effect on the technical
specifications, spare parts, the compatibility of any part, component or
performance. Such proposals shall also include an estimate of the change in the
price, if any, for the Instrument.

      3.2 MGM may not modify any component or part of the Instrument that may
affect form, fit, function, or appearance of the Instrument without obtaining
the prior written approval of Gen-Probe. Gen-Probe may at any time require
reasonable modifications which are directed to achieve compliance with the
Specifications or regulatory requirements. MGM will make any other modifications
to the Instrument reasonably requested by Gen-Probe. If the proposed
modifications will materially increase or decrease MGM's costs, the parties
agree that such changes will be implemented only after the parties have agreed
to a revised pricing schedule, reflecting such increased or decreased costs.

      3.3 All engineering changes shall be accomplished by Gen-Probe's written
acceptance of an Engineering Change Notice ("ECN"). Engineering changes that
result in an alteration of the form, fit, function, or appearance of a part,
assembly, Instrument or the device performance specifications shall be subject
to Sections 3.1 and 3.2, above.

      3.4 Modifications pursuant to this Article 3 does not require an amendment
to this Agreement, and all agreed upon modifications will automatically be
incorporated herein.

                                       2
<PAGE>

4.    SUPPLY OF INSTRUMENT AND PARTS

      4.1 The Instrument Supply Term shall commence on the Effective Date and
shall continue through December 31, 2005 ("Term"). Prior to the end of the Term,
the parties may agree to renew this Agreement for either one-, two-, or
three-year periods on the same terms and conditions by executing a Renewal
Agreement, an example of which is attached hereto as Exhibit G and incorporated
by reference herein.

      4.2 Gen-Probe shall submit purchase orders to MGM for its [...***...]
requirements of Instruments [...***...] in advance of the start of each
[...***...]. Gen-Probe shall further provide MGM a nonbinding [...***...]
rolling forecast as available.

      4.3 MGM shall, during the Term (including renewal periods) and for a
period of five (5) years after delivery of the last Instrument purchased
hereunder by Gen-Probe or its customers, supply or arrange to supply to
Gen-Probe or its customers all Parts for service and repair of the Instruments.
All Parts shall be identified and coded by MGM in the following categories: "A"
are items manufactured by MGM; "B" are items manufactured for MGM; and "C" are
items supplied only through a commercial source other than MGM. MGM will be
required to supply all Parts categorized as A and B or notify Gen-Probe of
alternate sources for category B. If MGM is not capable of supplying category A
Parts, it will provide Gen-Probe with detailed documentation including, but not
limited to, parts drawings, specifications, assembly instructions, and quality
specifications which will allow Gen-Probe to source these items from other
suppliers.

      4.4 MGM will manufacture all Instruments with packaging, labels, colors,
and markings as specified by Gen-Probe.

5.    PRICING

      5.1 The prices payable by Gen-Probe to MGM for each Instrument for the
current calendar year are set forth in Exhibit C. MGM warrants that said prices
are [...***...] prior to the start of a [...***...], MGM will provide a new
price list for the [...***...], based upon [...***...] forecast provided by
Gen-Probe. The prices shall be [...***...].

      5.2 Additional discounts/repayments for each calendar year may be agreed
upon by Gen-Probe and MGM, and any such additional discount/repayments will be
set forth in and made a part of Exhibit D, which is attached hereto, without the
necessity of amending this Agreement.

      5.3 Parts and materials shall be priced as shown on Exhibit E. These items
will be appropriately wrapped, packaged, and identified with Gen-Probe's and
MGM's part numbers, revision and description.

      5.4 All payments hereunder shall be in United States dollars. Terms of
payment for all invoices, [...***...], are [...***...].

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       3
<PAGE>

      5.5 Gen-Probe shall pay MGM a [...***...] on Instruments within
[...***...] days of each order placed as set out in Section 4.2. Terms of
payment for [...***...] will be [...***...];[...***...] will be given on
[...***...].

6.    RELIABILITY TESTING, SHIPMENT AND ACCEPTANCE

      6.1 MGM shall test all Instruments in accordance with the ATP and shall
deliver to Gen-Probe the Final Acceptance Test Data Sheet with the ATP. MGM will
pack all Instruments ordered hereunder suitably for shipment in accordance with
the accepted industry standards.

      6.2 MGM shall deliver Instruments in accordance with the schedule of
purchase orders placed by Gen-Probe. Title and risk of loss shall pass to
Gen-Probe at the MGM manufacturing facility. Freight will be collect with
carrier assigned by Gen-Probe.

      6.3 Upon delivery of any Instrument, Gen-Probe and/or its designee shall
have the right to inspect and test such item for defects and will notify MGM of
its acceptance or rejection thereof. Instrument shall be deemed accepted if not
rejected within [...***...] working days of receipt. Any Instrument rejected
shall be returned to MGM at MGM's cost with a written explanation specifying the
reason for such return; and MGM, at its sole cost, shall repair such defects or
replace such defective parts and reship such item or replacement to its original
destination within [...***...] of The Instrument's receipt by MGM.

      6.4 Gen-Probe will provide metrics of the incoming quality of Instruments
and spare parts as well as the quality of Instruments delivered to customers;
frequency to be at least quarterly. A continuous improvement process will be
established between the parties, with a minimum of one (1) meeting each quarter.

7.    SERVICE, MANUALS AND REPLACEMENT PARTS

      7.1 It is understood that upon delivery and acceptance of an Instrument by
Gen-Probe or its designee, all field service and maintenance shall be the
responsibility of Gen-Probe, except as otherwise required or provided in Article
10.

      7.2 MGM shall prepare and provide, at its cost, appropriate Operator's and
Service Manuals relating to each Instrument. The Operator's Manual shall
instruct the user of the Instrument regarding the proper usage and operation of
the unit, including all safety precautions and warnings necessary to adequately
inform the user of the potential for injury or harm from the use or operation of
the Instrument. The Service Manual shall instruct the service technician
regarding the proper diagnostics, testing, repair, maintenance, and other
required service of the Instrument, as well as all safety precautions and
warnings needed to adequately inform the service technician of the potential for
injury or harm from the service or use of the Instrument.

      7.3 MGM shall prepare in English the appropriate Service Manuals and
Operator's Manuals for the Instruments, including all schematics required for
the proper

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       4
<PAGE>

operation or service of the Instruments. MGM shall provide one copy of the
Operator's Manual with each lnstrument delivered at no additional cost over the
Instrument price. Gen-Probe shall have the right to make copies of the
Operator's Manual and Service Manual, including all schematics required to
service the Instruments and to provide such Operator's Manuals, Service Manuals
and schematics to its customers and any independent service organization which
it may designate to service Instruments.

8.    TERMINATION

      8.1 Either party may terminate this Agreement upon written notice to the
other party if the other party commits a material breach of this Agreement and
fails to cure such material breach within [...***...] after said written notice
identifying the breach.

      8.2 In addition to other provisions herein which survive termination or
expiration, termination or expiration of this Agreement shall not relieve MGM of
its obligations or warranties outlined in Section 10.3 and to supply Parts as
outlined in Section 4.3.

      8.3 Either party may terminate this Agreement for its convenience after
providing the other party a [...***...] prior written notice.

9.    FORCE MAJEURE

      9.1 Each party shall be excused from the performance of its obligations
hereunder in the event performance of this Agreement is prevented by a force
majeure and such excuse shall continue as long as the condition constituting
such force majeure continues, plus thirty (30) days after the termination of
such condition.

      9.2 For purposes of this Agreement, force majeure is defined as follows:
Causes beyond the control of MGM or Gen-Probe, including acts of God, war, any
regulations, acts, rules, orders, proclamations, requirements or laws of any
government, civil commotion, strike, lockout or other industrial dispute,
destruction of production facilities or material by fire, water, earthquake or
storm, plant breakdown or failure of equipment, inability to obtain equipment
and/or supplies, epidemics and failure of public utilities or common carriers or
by any circumstances whatsoever beyond a party's reasonable control.

10.   REPRESENTATIONS AND WARRANTIES

      10.1 MGM represents and warrants to Gen-Probe that it has full corporate
authority to enter into this Agreement, to consummate the transactions, and to
fulfill its obligations set forth herein.

      10.2 Gen-Probe represents and warrants to MGM that (i) it has full
corporate authority to enter into this Agreement, (ii) it will sell MGM products
with usage guidelines recommended by MGM, and (iii) it will not alter and sell
lnstruments in a manner not approved by MGM.

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       5
<PAGE>

      10.3 MGM will provide the following product warranty to Gen-Probe and its
customers/clients:

            10.3.1 The Instruments and Parts delivered will (i) perform in
accordance with the requirements of the Specifications, the ATP, and Article 12
of this Agreement; and (ii) be free from defects in material, design, and
workmanship for a period of twelve (12) months beginning from the date of
delivery of the lnstrument to Gen-Probe's customer, or eighteen (18) months
beginning from the date of delivery to Gen-Probe, whichever is longer (the
"Warranty Period"). As to any such lnstrument defect, MGM shall be relieved of
all obligations of liability under this Section 10.3.1 if the Instrument is
operated with any accessory or part not manufactured in accordance with the
approved Specifications, or is operated with any fluid or material not jointly
approved by MGM and Gen-Probe, or is not operated or maintained in accordance
with the Operator's and/or Service Manuals.

            10.3.2 Should any of the Instruments or Parts fail to conform with
the foregoing warranty under normal and proper use and maintenance, MGM shall,
upon receipt of prompt notice thereof, at MGM's option (i) replace without
charge any Instrument or Part manufactured by it which is found to be defective;
or (ii) repair such Instrument or Part at MGM's sole expense upon return to
MGM's facility in a decontaminated condition pursuant to Decontamination
Procedures as outlined in Exhibit F; or (iii) pay Gen-Probe to repair such
Instrument or Part. In all cases, MGM shall pay all shipping costs.

            10.3.3 After acceptance of an Instrument by Gen-Probe and delivery
to a customer, all non-warranty field service and maintenance of the Instrument
conducted at the customer site shall be the responsibility of Gen-Probe or its
designee.

11.   CONFIDENTIALITY OBLIGATIONS

      All proprietary and confidential information in connection with the
activities contemplated herein (including, without limitation, technical
information, marketing information, and vendor information) exchanged between
MGM and Gen-Probe during the Term and for a period of seven years following
termination or expiration shall be treated as confidential information of the
disclosing party, and the receiving party shall never use such information for
any purpose other than furtherance of this Agreement, or disclose such
information to any third party without the prior written approval of the other
party unless such information (a) has become public knowledge through no fault
of the party receiving such information, (b) lawfully comes to such party from a
third party under no obligation of confidentiality with respect to such
information, (c) was in the possession of such party as evidenced by its written
records prior to the date of disclosure, (d) was independently developed by
receiving party as evidenced by its written records or (e) is required by law or
regulation to be disclosed, provided that the party so required to disclose
confidential information shall give the disclosing party sufficient notice (in
no case less than four (4) days) of the proposed disclosure to oppose or limit
disclosure or to seek a protective order for such information. Both parties
shall use the same precautions to prevent the unauthorized disclosure of

                                       6
<PAGE>

confidential information to third parties that they take to prevent the
unauthorized disclosure of their own confidential information.

12.   COMPLIANCE WITH LAW: QUALITY ASSURANCE POLICY

      12.1 With respect to all instruments and Parts sold to Gen-Probe
hereunder, MGM agrees to manufacture and furnish same in compliance with all
applicable federal, state, and local laws and regulations including, but not
limited to: (a) the Federal Food, Drug and Cosmetics Act, as amended, including,
without limitation, then current Good Manufacturing Practices as established by
the United States Food and Drug Administration, (b) Canadian CSA Standards, (c)
European Community Council Directive 89/336/EEC, the EMC Directive and Directive
73/23/EEC, the Low Voltage Directive, and (d) the Japanese Ministry of Health
and Welfare Koseisho guidelines, including, but not limited to, all Japanese
electrical requirements.

      12.2 Gen-Probe may, at its expense, inspect and audit lnstrument
manufacture and handling at MGM's facilities to confirm compliance with Section
12.1 above. The date and time of such inspections shall be mutually agreed upon.

13.   ASSIGNMENT

      Neither party shall have any right or ability to assign, transfer, or
sublicense any obligations or benefit under this Agreement without the written
consent of the other party except that either party may, without restriction,
assign and transfer this Agreement and its rights and obligations hereunder to
any affiliate who succeeds to substantially all its business or assets.

14.   INDEPENDENT CONTRACTOR

      Notwithstanding any provision hereof, for all purposes of this Agreement
each party shall act as an independent contractor and not as a partner, joint
venturer, franchisee, employee, agent, representative, or participant of or with
the other for any purpose whatsoever. MGM agrees that all services hereunder
will be rendered by MGM as an independent contractor. Neither party shall have
any right or authority whatsoever to assume or to create any obligation or
responsibility, express or implied, on behalf of the other party.

15.   HEADINGS

      The headings in this Agreement are for reference purposes only and shall
not affect in any way the meaning or interpretation of this Agreement.

16.   ARBITRATION

      Any controversy, claim or dispute existing out of or relating to this
Agreement, or the breach thereof, shall be resolved by binding arbitration, with
any proceedings or hearings to take place in a mutually agreed upon location;
and any judgment upon the award rendered by arbitration may be entered in any
Court having jurisdiction. If

                                       7
<PAGE>

arbitration is necessary pursuant to this paragraph, the parties shall agree
upon a single arbitrator. If the parties are unable to agree on an arbitrator,
then they will obtain nominations of three potential arbitrators from
JAMS/Endispute and each party will have the right to strike one candidate's name
from the list. JAMS/Endispute will then designate the arbitrator. Any
arbitration award shall also include, but shall not be limited to, any and all
court or arbitration costs, attorney fees and any other costs or charges
reasonably necessary to adjudicate the controversy, in addition to any and all
damages deemed fair by the Arbitrator(s). Nothing contained herein shall deprive
any party of its right to obtain injunctive or other equitable relief.

17.   THIRD PARTY LEGAL ACTIONS

      17.1 Each party shall be obligated to ensure that the other party is
promptly notified concerning any of the legal actions instituted during the term
of this Agreement which could effect the other or concern the subject matter of
this Agreement.

      17.2 Each party shall be responsible for its own defense in any action
brought against that party under this Agreement.

      17.3 Each party agrees to provide reasonable cooperation and assistance to
the other in connection with any third party suit, without any charge therefor
other than reasonable out-of-pocket expenses.

18.   NOTICES

      Any notices given by one party to the other hereunder shall be in the
English language and shall be sent to the address/fax number set forth below
(provided that any party may at any time change its address for notice or other
such information by giving written notice thereof in accordance with this
Section), and shall be deemed to be duly given upon the earliest of (a) hand
delivery, (b) the first business day after sending by reputable overnight
delivery service for next-day delivery, (c) the third business day after sending
by first class United States mail, postage prepaid, (d) the time of successful
facsimile transmission (or in the event the time of receipt of the fax in the
city where the fax is received is not during regular business hours on a
business day, then at the customary hour for the opening of business on the next
business day), provided that a complete copy of the notice is also sent by first
class United States mail (postage prepaid) on the same day as facsimile
transmission or on the next business day, or (e) the date actually received by
the other party:

            To GEN-PROBE:     Gen-Probe Incorporated
                              Attention:  Henry L. Nordhoff
                              Chairman, President, & Chief Executive Officer
                              10210 Genetic Center Drive
                              San Diego, CA 92121
                              Fax:  [...***...]
                              cc:  General Counsel - Fax: [...***...]

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       8
<PAGE>

            To MGM:           MGM Instruments, Inc.
                              Attention: George Mismas, Chief Executive Officer
                              925 Sherman Avenue
                              Hamden CT 06514
                              Fax:  [...***...]

19.   GOVERNING LAW

      The laws of the State of California shall govern this Agreement without
regard to its conflicts of laws principles. All actions arising therefrom shall
be brought in the State Court of California located in San Diego, California or,
in the case of federal jurisdiction, in the United States District Court for the
Southern District of California. The parties hereby submit to the venue and
personal jurisdiction of such courts.

20.   SURVIVABILITY

      The following provisions shall survive the termination or expiration of
this Agreement: Articles 1, 10, 11, 12, 13, 15, 16, 17, 18, and 19 and Sections
4.3, 4.4, and 8.2.

21.   ENTIRE AGREEMENT

      This Agreement constitutes the entire agreement and understanding between
the parties with respect to the subject matter hereof and there are no promises,
representations, conditions, warranties, commitments, understandings, provisions
or terms related thereto other than those set forth in this Agreement, and this
Agreement supersedes all previous understandings, agreements and representations
between the parties, written or oral with respect to the subject matter hereof.
The provisions of this Agreement may not be waived, changed, modified, or
amended except by a writing signed by both parties.

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       9
<PAGE>

      IN WITNESS WHEREOF, the parties have caused this Agreement to be executed
by their duly authorized representatives as of the date first written above.

GEN-PROBE INCORPORATED                            MGM INSTRUMENTS, INC.

By:/s/ Henry L. Nordhoff                          By:/s/ George Mismas
   ------------------------------------              --------------------------
   Henry L. Nordhoff                                 George Mismas
   Chairman, President, & CEO                        Chief Executive Officer

                                       10
<PAGE>

                                  EXHIBIT LLST

"A"   FINAL ACCEPTANCE TEST PROCEDURES ("ATP")

"B"   (INTENTIONALLY OMITTED)

"C"   LlST OF INSTRUMENTS/PRICING

"D"   ADDITIONAL DISCOUNTS AND REPAYMENTS

"E"   SPARE PARTS PRICE LlST

"F"   DECONTAMINATION PROCEDURES

"G"   RENEWAL AGREEMENT FORM

"H"   AGREEMENT AMENDMENT FORM

                                       11
<PAGE>

                                    EXHIBIT A

                    FINAL ACCEPTANCE TEST PROCEDURES ("ATP")

The appropriate Final Acceptance Test Procedure shall be referenced by MGM in
their final inspection documentation per Section 6.1. Final Acceptance Test
Procedures are subject to revision per Section 3. Gen-Probe shall update MGM as
revisions occur.

<TABLE>
<CAPTION>
ATP NUMBER                         DESCRIPTION
----------                         -----------
<S>                                <C>
[...***...]                        [...***...]
[...***...]                        [...***...]
[...***...]                        [...***...]
[...***...]                        [...***...]
[...***...]                        [...***...]
</TABLE>

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       12
<PAGE>

                                    EXHIBIT B

                             (INTENTIONALLY OMITTED)

                                       13
<PAGE>

                                    EXHIBIT C

                           LIST OF INSTRUMENTS/PRICING

<TABLE>
<CAPTION>
MGM CATALOG #
PART NUMBER               GEN-PROBE           DESCRIPTION                 U. S. DOLLAR PRICE
-----------               ---------           -----------                 ------------------
<S>                       <C>                 <C>                         <C>
[...***...]               [...***...]         [...***...]                     [...***...]
[...***...]               [...***...]         [...***...]                     [...***...]
[...***...]               [...***...]         [...***...]                     [...***...]
[...***...]               [...***...]         [...***...]                     [...***...]
[...***...]               [...***...]         [...***...]                     [...***...]
[...***...]               [...***...]         [...***...]                     [...***...]
[...***...]               [...***...]         [...***...]                     [...***...]
[...***...]               [...***...]         [...***...]                     [...***...]
</TABLE>

                                               *CONFIDENTIAL TREATMENT REQUESTED

                                       14
<PAGE>

                                    EXHIBIT E

                             SPARE PARTS PRICE LIST

                                   (ATTACHED)

                                       15
<PAGE>

                                   Page 1 of 5

                                    EXHIBIT E

<TABLE>
<CAPTION>
                         GEN-PROBE                                         2002 SPARE
  MGM P/N                   P/N                 DESCRIPTION               PARTS PRICING
  -------                   ---                 -----------               -------------
<S>                      <C>                    <C>                       <C>
[...***...]
</TABLE>

                                               *CONFIDENTIAL TREATMENT REQUESTED

<PAGE>

                                   Page 2 of 5

<TABLE>
<CAPTION>
                         GEN-PROBE                                         2002 SPARE
  MGM P/N                   P/N                 DESCRIPTION               PARTS PRICING
  -------                   ---                 -----------               -------------
<S>                      <C>                    <C>                       <C>
[...***...]
</TABLE>

                                               *CONFIDENTIAL TREATMENT REQUESTED

<PAGE>

                                   Page 3 of 5

<TABLE>
<CAPTION>
                         GEN-PROBE                                         2002 SPARE
  MGM P/N                   P/N                 DESCRIPTION               PARTS PRICING
  -------                   ---                 -----------               -------------
<S>                      <C>                    <C>                       <C>
[...***...]
</TABLE>

                                               *CONFIDENTIAL TREATMENT REQUESTED

<PAGE>

                                   Page 4 of 5

<TABLE>
<CAPTION>
                         GEN-PROBE                                         2002 SPARE
  MGM P/N                   P/N                 DESCRIPTION               PARTS PRICING
  -------                   ---                 -----------               -------------
<S>                      <C>                    <C>                       <C>
[...***...]
</TABLE>

                                               *CONFIDENTIAL TREATMENT REQUESTED

<PAGE>

                                   Page 5 of 5

<TABLE>
<CAPTION>
                         GEN-PROBE                                         2002 SPARE
 MGM P/N                    P/N                 DESCRIPTION               PARTS PRICING
 -------                    ---                 -----------               -------------
<S>                      <C>                    <C>                       <C>
[...***...]
</TABLE>

                                               *CONFIDENTIAL TREATMENT REQUESTED

<PAGE>

                                    EXHIBIT F

                           DECONTAMINATION PROCEDURES

1.    PURPOSE: To define procedures for the cleaning and disinfecting of
      instruments returned to Gen-Probe for service and repair.

2.    SCOPE: This procedure will be followed when a specific procedure is not
      included in the QOP for the Instrument. It is intended for lnstruments
      returned to Gen-Probe from a customer site prior to performing any service
      or repair work. It does not apply to new lnstruments received from a
      manufacturer or vendor.

3.    REFERENCE DOCUMENTS:

      QOP 0011 General Instrumentation Operating Procedure

4.    SUPPLIES:

      4.1   10% Bleach solution. Prepare by diluting 1 part by volume commercial
            bleach (containing ca. 5% sodium hypochlorite) with 9 parts by
            volume Dl or AE water. Label prepared solution with date of
            preparation. Use within one week of preparation date.

      4.2   Paper towels

      4.3   Lab coat

      4.4   Latex or nitrile gloves

      4.5   lnstrument Repair Report

5     PREPARATION PROCEDURE:

      5.1   Before proceeding with the cleaning procedure, ensure that you are
            wearing a lab coat and protective gloves.

      5.2   Prepare area by ensuring that there is sufficient quantity of 10%
            bleach solution prepared and the lab area is clean and there are
            sufficient supplies such as paper towels, etc.

      5.3   Each instrument that is brought into the area designated for
            cleaning cannot be removed from the area until the cleaning
            procedure is complete.

      5.4   Initiate an lnstrument Repair Report form or Quality Control Form
            ("QCF"), as appropriate for each instrument. Complete the top
            portion of the form.

                                       16
<PAGE>

                                    EXHIBIT F

                     DECONTAMINATION PROCEDURES (Continued)

6     CLEANING PROCEDURE

      6.1   Open carton containing the instrument and place it on a bench or
            cart. Set aside all packing material and the carton. If these items
            cannot be reused, discard in the appropriate waste container.

      6.2   Wipe down the outside of the instrument with the 10% bleach
            solution. Open lid and inspect interior chamber. lnspect for any
            solutions returned by the customer and dispose of them properly. If
            there is any doubt, contact the Biological safety officer. Discard
            any returned tubes.

      6.3   Wipe the inside chamber(s) thoroughly with the 10% bleach solution.
            Do not use excessive solution or allow any "puddling" of the
            cleaning solution.

      6.4   lnspect for any reagent damage and note this on the lnstrument
            Repair Report. Record on the lnstrument Repair Report any missing
            components such as pump assembly, power cord, cassettes, etc. that
            should have been included with the instrument.

      6.5   Thoroughly dry all surfaces with paper towels.

      6.6   After cleaning, move instrument into the repair area. Document on
            the instrument QOP or QCF that the cleaning procedure has been
            completed.

      6.7   Dispose of all used supplies. Do not return unused cleaning solution
            to the stock bottles.

      6.8   Notify your supervisor of any irregularities.

                                       17
<PAGE>

                                    EXHIBIT G

                                RENEWAL AGREEMENT
                                 RENEWAL NUMBER

      THIS RENEWAL AGREEMENT is made and entered into as of ________________, by
and between:

MGM INSTRUMENTS, INC., with offices at 925 Sherman Avenue, Hamden, Connecticut
06514 ("MGM") and

GEN-PROBE INCORPORATED, with offices at 10210 Genetic Center Drive, San Diego,
California 92121-4362 ("Gen-Probe")

                                    RECITALS

      WHEREAS, MGM and Gen-Probe entered into a Supply Agreement ("Agreement")
having an effective date of ;

      WHEREAS, MGM and Gen-Probe wish to amend the Agreement;

      NOW, THEREFORE, the parties agree as follows:

                                      TERMS

1. The term of the Agreement shall be extended for the time period commencing
and terminating .

2. All other terms and conditions remain unchanged and in full force and effect.

3. This Renewal Agreement shall become effective on .

      IN WITNESS WHEREOF, the parties have entered into this Renewal Agreement
on the day and year written above.

GEN-PROBE INCORPORATED                           MGM INSTRUMENTS, INC.

By: ___________________________________          By:____________________________
      Henry L. Nordhoff                          George Mismas
      President & Chief Executive Officer        Chief Executive Officer

                                       18
<PAGE>

                                    EXHIBIT H

                                SUPPLY AGREEMENT
                                AMENDMENT NUMBER

      THIS SUPPLY AGREEMENT AMENDMENT is made and entered into as of , by and
between:

MGM INSTRUMENTS, INC. ("MGM"), with offices at 925 Sherman Avenue, Hamden,
Connecticut 06514 and

GEN-PROBE INCORPORATED ("Gen-Probe"), with offices at 10210 Genetic Center
Drive, San Diego, California 92121.

                                    RECITALS

      WHEREAS, MGM and Gen-Probe entered into a Supply Agreement having an
effective date of ("Agreement");

      WHEREAS, MGM and Gen-Probe wish to amend the Agreement;

      NOW, THEREFORE, the parties agree as follows:

                                      TERMS

1. The terms of the Agreement shall be amended as follows:

2. All other terms and conditions remain unchanged and in full force and effect.

3. This Agreement Amendment shall become effective on .

      IN WITNESS WHEREOF, the parties have entered into this Amendment Agreement
by their duly authorized representatives.

GEN-PROBE INCORPORATED                        MGM INSTRUMENTS, INC.

By: __________________________________        By: ______________________________
      Henry L. Nordhoff                       George Mismas
      President & Chief Executive Officer     Chief Executive Officer

                                       19

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