Document:

EXHIBIT 10.1
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               FOURTEENTH AMENDMENT TO LOAN AND SECURITY AGREEMENT
               ---------------------------------------------------

     This Fourteenth Amendment to Loan and Security Agreement (the "Fourteenth
Amendment") is made as of March 31, 2006 by and between Proliance International,
Inc., ("Proliance"), Ready Aire, Inc. ("RA"; together with Proliance, the
"Borrowers"), Proliance International, S.A. de C.V. ("Proliance Mexico") and
Radiadores GDI, S.A. de C.V. ("Radiadores"; together with Proliance Mexico, the
"Obligors"), and Wachovia Capital Finance Corporation (New England), formerly
known as Congress Financial Corporation (New England), as lender (the "Lender").

     WHEREAS, the Lender, Borrowers and Obligors are parties to that certain
Loan and Security Agreement dated as of January 4, 2001, as amended by the First
Amendment to Loan and Security Agreement dated as of July 2001 ("First
Amendment"), the Second Amendment to Loan and Security Agreement dated as of
July 30, 2001 ("Second Amendment"), the Third Amendment to Loan and Security
Agreement dated as of November 27, 2001 ("Third Amendment"), the Fourth
Amendment to Loan and Security Agreement dated as of December 31, 2001 ("Fourth
Amendment"), the Fifth Amendment to Loan and Security Agreement dated as of
February 20, 2002 ("Fifth Amendment"), the Sixth Amendment to Loan and Security
Agreement dated as of December 31, 2001 ("Sixth Amendment"), the Seventh
Amendment to Loan and Security Agreement dated as of July 1, 2002 ("Seventh
Amendment"), the Eighth Amendment to Loan and Security Agreement dated as of
November 22, 2002 ("Eighth Amendment"), the Ninth Amendment to Loan and Security
Agreement dated as of December 27, 2002 ("Ninth Amendment"), the Tenth Amendment
to Loan and Security Agreement dated as of November 19, 2004 (the "Tenth
Amendment"), the Eleventh Amendment to Loan and Security Agreement dated as of
March 2, 2005 (the "Eleventh Amendment"), the Twelfth Amendment to Loan and
Security Agreement dated as of July 21, 2005 (as amended by that certain
Amendment to Twelfth Amendment dated September 30, 2005 and that certain Second
Amendment to Twelfth Amendment dated November 30, 2005, the "Twelfth
Amendment"), and the Thirteenth Amendment to Loan and Security Agreement dated
as of October 20, 2005 (the "Thirteenth Amendment") (as amended hereby and as
the same may be supplemented, amended, restated or modified from time to time,
the "Loan Agreement"); all capitalized terms not otherwise defined herein shall
have the meanings given such terms in the Loan Agreement;

     WHEREAS, Borrowers have requested that Lender amend certain provisions of
the Loan Agreement as set forth herein; and

     WHEREAS, the Lender has agreed to amend certain provisions of the Loan
Agreement subject to the terms and conditions hereof;

     NOW THEREFORE, based on these premises, and in consideration of the mutual
promises contained herein and for other good and valuable consideration, the
receipt and sufficiency of which are hereby acknowledged by the parties, the
Borrowers, the Obligors

and the Lender hereby agree as follows:

           1. Amendments to Loan Agreement.

           1.1. Definitions. The following definitions are added to Section 1 of
the Loan Agreement in proper alphabetical order (such definitions hereby replace
in entirety the same definitions set forth in the Loan Agreement):

               (a) "Capital Stock" shall mean, with respect to any Person, any
           and all shares, interests, participations or other equivalents
           (however designated) of such Person's capital stock, partnership
           interests or limited liability company interests at any time
           outstanding, and any and all rights, warrants or options exchangeable
           for or convertible into such capital stock or other interests (but
           excluding any debt security that is exchangeable for or convertible
           into such capital stock).

               (b) "EBITDA" shall mean the sum, without duplication, of the
           following for any applicable period as determined on a consolidated
           basis in accordance with GAAP for Proliance and its wholly owned
           Subsidiaries: (a) Net Income (but excluding Net Income of, or gain
           from the sale of, G&O Manufacturing Company, Inc.), plus (b) interest
           expense on all indebtedness to the extent deducted in determining Net
           Income, plus (c) taxes on income to the extent deducted in
           determining Net Income, plus (d) depreciation expense to the extent
           deducted in determining Net Income, plus (e) amortization expense to
           the extent deducted in determining Net Income, minus (f) non-cash
           gain or plus non-cash loss from the sale of assets, other than sales
           in the ordinary course of business but only to the extent added to or
           deducted in determining Net Income, and minus (g) negative goodwill
           to the extent added in determining Net Income.

               (c) "Fixed Charge Coverage Ratio" shall mean, for any applicable
           period as determined in accordance with GAAP on a consolidated basis
           for Proliance and its wholly owned Subsidiaries, the ratio of (a)
           EBITDA minus Capital Expenditures made in cash to (b) Fixed Charges.

               (d) "Fixed Charges" shall mean, for any applicable period as
           determined in accordance with GAAP on a consolidated basis for
           Proliance and its wholly owned Subsidiaries, the amount equal to
           (without duplication): (a) the aggregate amount of interest,
           including payments in the nature of interest under capital leases,
           paid or accrued by Proliance and its wholly owned Subsidiaries
           (whether such interest is reflected as an item of expense or

                                       2

           capitalized) on Indebtedness, plus (b) the aggregate amount of all
           mandatory scheduled payments, prepayments and sinking fund payments,
           in each case with respect to principal paid or accrued by Proliance
           and its wholly owned Subsidiaries in respect of Indebtedness except
           for principal payments made on account of Revolving Loans (with the
           exception of such payments made upon a permanent reduction in the
           Revolving Loan Ceiling) plus (c) any dividends or distributions paid
           or payable by Proliance and its wholly owned Subsidiaries (other than
           dividends or distributions paid or payable from any such Subsidiary
           to Proliance) plus (d) income taxes paid by Proliance or its wholly
           owned Subsidiaries.

               (e) "Net Income" shall mean the net income (or loss) of Proliance
           and its wholly owned Subsidiaries on a consolidated basis as
           determined in accordance with GAAP.

               (f) "Subsidiary" or "subsidiary" shall mean, with respect to any
           Person, any corporation, limited liability company, limited liability
           partnership or other limited or general partnership, trust,
           association or other business entity of which an aggregate of at
           least a majority of the outstanding Capital Stock or other interests
           entitled to vote in the election of the board of directors of such
           corporation (other than Capital Stock of any other class or classes
           of such corporation having such voting power by reason of the
           happening of any contingency), managers, trustees or other
           controlling persons, or an equivalent controlling interest therein,
           of such Person is, at the time, directly or indirectly, owned by such
           Person and/or one or more subsidiaries of such Person.

           1.2. Financial Covenants.

               (a) Minimum EBITDA. Section 9.20 of the Loan Agreement is hereby
deleted in its entirety and the following is substituted in lieu thereof:

           "9.20 Minimum EBITDA. Borrowers shall achieve, on a consolidated
           basis, EBITDA of not less than the amounts set forth below for the
           twelve consecutive month periods ending on the dates set forth below:

           ---------------------------------------------------------------------
           Test Date                                          Amount
           ---------------------------------------------------------------------
           December 31, 2005                                  ($21,800,000)
           ---------------------------------------------------------------------
           March 31, 2006                                     ($21,800,000)
           ---------------------------------------------------------------------
           June 30, 2006                                      ($12,500,000)
           ---------------------------------------------------------------------

                                       3

           ---------------------------------------------------------------------
           September 30, 2006                                  $4,000,000
           ---------------------------------------------------------------------
           December 31, 2006                                   $18,500,000
           ---------------------------------------------------------------------
           March 31, 2007                                      $20,000,000
           ---------------------------------------------------------------------
           June 30, 2007                                       $20,000,000
           ---------------------------------------------------------------------
           September 30, 2007                                  $21,200,000
           ---------------------------------------------------------------------

           Compliance with the foregoing EBITDA covenant will not be required on
           any test date if Excess Availability equals or exceeds $15,000,000 at
           all times during the calendar quarter immediately preceding such test
           date."

               (b) Minimum Excess Availability. Section 9.20A is hereby deleted
in its entirety and the following is substituted in lieu thereof:

           "9.20A Minimum Excess Availability. The Borrowers shall maintain
           Excess Availability equal to or in excess of (i) $3,000,000 from
           March 31, 2006 through May 31, 2006 and (ii) $5,000,000 from June 1,
           2006 through June 30, 2006. Solely for the purpose of this Section
           9.20A, Excess Availability shall be determined without regard to the
           limitation that the Maximum Credit and the Revolving Loan Ceiling
           place on the Revolving Loans available to the Borrowers."

               (c) Fixed Charge Coverage Ratio. The following Section 9.20C is
hereby added to the Loan Agreement in proper numerical order:

           "9.20C Fixed Charge Coverage Ratio. On December 31, 2007, and on each
           March 31, June 30, September 30 and December 31 thereafter, in each
           case for the twelve months then ended, Borrowers shall maintain, on a
           consolidated basis, a Fixed Charge Coverage Ratio (as defined herein)
           of not less than 1.00 to 1.00.

           Compliance with the foregoing Fixed Charge Coverage Ratio covenant
           will not be required on any test date if Excess Availability equals
           or exceeds $15,000,000 at all times during the three month period
           immediately preceding such test date."

           2. Limited Waiver. The Borrowers have requested that certain
covenants set forth in Section 1.3 of the Fourth Amendment and Section 5.13 of
the Twelfth Amendment be waived, and Lender, subject to the terms, conditions
and covenants set forth in this Section 2, has agreed to the following,

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               2.1. Deposit Account Control Agreements. Subject to the terms,
           conditions and covenants set forth in this Section 2, the Lender
           hereby waives the Borrowers' obligation under Section 1.3 of the
           Fourth Amendment and Section 5.13 of the Twelfth Amendment to deliver
           to the Lender a deposit account control agreement with respect to
           Account # 646927012 (the "Account") held in the name of Proliance at
           JPMorgan Chase Bank, N.A., provided that the Borrowers covenant and
           agree not to maintain more than $25,000 in the Account at any time.
           Upon the occurrence of an Event of Default or Borrowers' failure to
           comply with the covenant set forth in the first sentence of this
           Section 2.1, and at the direction of the Lender, Borrowers shall
           promptly (but in any event within one Business Day) (i) close the
           Account and (ii) transfer by wire all funds then held in the Account
           to the Payment Account of the Lender.

               2.2. Limited Waiver. The limited waiver set forth in this Section
           2 is and shall be effective solely for the specific instance and
           purpose described herein and is not and shall not be applicable to
           any other provision of the Loan Agreement or the other Financing
           Agreements or to any future event or condition. The execution and
           delivery of this limited waiver by the Lender shall not be construed
           as a waiver by the Lender of any other term, covenant, condition or
           agreement under the Loan Agreement or the other Financing Agreements.

           3. Conditions Precedent. The following are all of the conditions
precedent to the effectiveness of this Fourteenth Amendment and the agreements
of the Lender hereunder:

               3.1. payment to Lender in immediately available funds of all
           documented out-of-pocket expenses, including, without limitation,
           reasonable attorneys' fees and disbursements, incurred by the Lender
           through the date hereof, in accordance with Section 7 hereof;

               3.2. receipt by Lender of this Fourteenth Amendment, duly
           executed by the Borrowers and Obligors;

               3.3. each of the representations and warranties set forth in
           Section 4 hereof is true, accurate and correct in all material
           respects as of the date hereof (or such other date referenced in
           Section 4 hereof).

           4. Representations and Warranties. Each Borrower and Obligor jointly
and severally represents and warrants to Lender the following, as applicable:

               4.1. Organization and Qualification. Each of the Borrowers and
           Obligors is duly incorporated or formed, as applicable, validly
           existing, and in good standing under the laws of their respective
           jurisdictions of incorporation or formation, as applicable. Each
           Borrower and Obligor is duly qualified to do business and is in good
           standing as a foreign corporation or other applicable organization in
           all states and jurisdictions in which the failure to be so qualified

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           would have a material adverse effect on the financial condition,
           business or properties of such Borrower or Obligor.

               4.2. Power and Authority. Each Borrower and Obligor are duly
           authorized and empowered to enter, deliver, and perform this
           Fourteenth Amendment. The execution, delivery, and performance of
           this Fourteenth Amendment has been duly authorized by all necessary
           corporate action of each of the applicable Borrowers and Obligors.
           The execution, delivery and performance of this Fourteenth Amendment
           do not and will not (i) require any consent or approval of the
           shareholders of the Borrowers or the Obligors; (ii) contravene the
           charter or by-laws or equivalent organizational documents of any of
           the Borrowers or Obligor; (iii) violate or cause any Borrower or
           Obligor to be in default under, any provision of any law, rule,
           regulation, order, writ, judgment, injunction, decree, determination
           or award in effect having applicability to such Borrower or Obligor;
           (iv) result in a breach of or constitute a default under any
           indenture or loan or credit agreement or any other agreement, lease
           or instrument to which any Borrower or Obligor is a party or by which
           such Borrower's or Obligor's properties may be bound or affected,
           which breach or default is reasonably likely to have a material
           adverse effect on the financial condition, business or properties of
           such Borrower or Obligor; or (v) result in, or require, the creation
           or imposition of any lien (other than the liens set forth in Schedule
           8.4 to the Loan Agreement) upon or with respect to any of the
           properties now owned or hereafter acquired by any Borrower or
           Obligor.

               4.3. Legally Enforceable Agreement. This Fourteenth Amendment is
           a legal, valid and binding obligation of each of the Borrowers and
           Obligors and is enforceable against each of the Borrowers and
           Obligors in accordance with the terms hereof subject to bankruptcy,
           reorganization, moratorium or similar laws affecting the enforcement
           of creditors' rights generally.

               4.4. Continuous Nature of Representations and Warranties. Each
           Borrower confirms and agrees that, except for the amendments to the
           Loan Agreement provided herein and in the other previously executed
           amendments to the Loan Agreement, (a) all representations and
           warranties contained in the Loan Agreement and in the other Financing
           Agreements (as amended prior to the date hereof and pursuant to this
           Fourteenth Amendment) are on the date hereof true and correct in all
           material respects (except with respect to deviations therefrom
           permitted under Article 9 of the Loan Agreement) except to the extent
           that such representations and warranties expressly relate to a
           specific earlier date in which case the Borrowers confirm, reaffirm
           and restate such representations and warranties as of such earlier
           date, (b) all Information Certificates delivered in conjunction with
           the Loan Agreement and the Twelfth Amendment to Loan and Security
           Agreement dated as of July 21, 2005, as the same may be amended
           and/or restated, remain true and correct in all material respects and
           (c) it is unconditionally, absolutely, and jointly and severally
           liable for the punctual and full performance and payment of all
           Obligations, including, without limitation, all termination fees
           under Section 12.1(c) of the Loan Agreement, charges, fees, expenses
           and costs (including attorneys' fees and expenses) under the
           Financing Agreements, and that

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           no Borrower has any defenses, counterclaims or setoffs with respect
           to full, complete and timely payment of all Obligations.

           5. Acknowledgement of Obligations. Each Obligor, for value received,
hereby consents to the Borrowers' execution and delivery of this Fourteenth
Amendment, and the performance by the Borrowers of their respective agreements
and obligations hereunder. The Borrowers' performance and/or consummation of any
transaction or matter contemplated under this Fourteenth Amendment shall not
limit, restrict, extinguish or otherwise impair any of the Obligors' obligations
to Lender with respect to the Financing Agreements, as applicable. Each Obligor
acknowledges that it is unconditionally liable to Lender for the full and
complete payment of all Obligations, including, without limitation, all charges,
fees, expenses and costs (including attorney's fees and expenses) under the
Financing Agreements and that such Obligor has no defenses, counterclaims or
setoffs with respect to full, complete and timely payment of any and all
Obligations.

           6. Confirmation of Liens. Each Borrower and Obligor acknowledges,
confirms and agrees that the Financing Agreements, as amended hereby, are
effective to grant to Lender duly perfected, valid and enforceable first
priority security interests in and liens on the Collateral described therein,
except for liens permitted under Sections 8.4 and 9.8 and Schedule 8.4 of the
Loan Agreement, and that the locations for such Collateral specified in the
Financing Agreements have not changed except as provided herein or as previously
disclosed to the Lender. Each Borrower and Obligor further acknowledges and
agrees that all Obligations of the Borrowers are and shall be secured by the
Collateral.

           7. Miscellaneous. All capitalized terms not otherwise defined herein
shall have the meanings ascribed to them in the Financing Agreements. Borrowers
hereby agree to pay to Lender all reasonable attorney's fees and costs which
have been incurred or may in the future be incurred by Lender in connection with
the negotiation, preparation, performance and enforcement of this Fourteenth
Amendment and any other documents and agreements prepared and/or reviewed in
connection herewith. The undersigned confirm that the Financing Agreements
remain in full force and effect without amendment or modification of any kind,
except for as set forth in this Fourteenth Amendment (and as set forth in any
previously executed amendments to the Loan Agreement). The Borrowers and
Obligors further confirm that no Event of Default or events which with notice or
the passage of time or both would constitute an Event of Default have occurred
and are continuing. The execution and delivery of this Fourteenth Amendment by
Lender shall not be construed as a waiver by Lender of any Event of Default
under the Financing Agreements. This Fourteenth Amendment shall be deemed to be
a Financing Agreement and, together with the other Financing Agreements,
constitute the entire agreement between the parties with respect to the subject
matter hereof and supersedes all prior dealings, correspondence, conversations
or communications between the parties with respect to the subject matter hereof.

                      REST OF PAGE LEFT INTENTIONALLY BLANK

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                        Signature page to Fourteenth Amendment to Loan Agreement

     IN WITNESS WHEREOF, the Borrowers, the Obligors, and the Lender have
executed this Fourteenth Amendment as of the date first above written, by their
respective officers hereunto duly authorized, under seal.

                                             BORROWERS:

WITNESS                                      PROLIANCE INTERNATIONAL, INC.

/s/ R. C. Freeman                            By: /s/ R. A. Wisot
----------------------------------               -----------------------------
                                             Title: Vice President

                                             READY AIRE, INC.

/s/ R. C. Freeman                            By: /s/ R. A. Wisot
----------------------------------           ---------------------------------
                                             Title: Vice President

                                       8

                        Signature page to Fourteenth Amendment to Loan Agreement

                                             OBLIGORS:
                                             ---------

                                             PROLIANCE INTERNATIONAL, S.A. de
                                             C.V.

/s/ R. C. Freeman                            By: /s/ R. A. Wisot
----------------------------------               ------------------------------
                                             Title: Vice President
                                                    ---------------------------

                                             RADIADORES GDI, S.A. de C.V.

/s/ R. C. Freeman                            By: /s/ R. A. Wisot
----------------------------------               ------------------------------
                                             Title: Vice President
                                             ----------------------------------

                                             LENDER:
                                             -------

                                             WACHOVIA CAPITAL FINANCE
                                             CORPORATION (NEW ENGLAND)

/s/ Michelle Simon Long                      By: /s/ Willis A. Williams
----------------------------------               ------------------------------
                                             Title: Vice President
                                             ----------------------------------

                                       9CONSULTING AGREEMENT

This CONSULTING AGREEMENT (the "AGREEMENT"), is made as of April 1, 2006 (the
"EFFECTIVE DATE") by and between:

VION PHARMACEUTICALS, INC.       a Delaware corporation, having a place of
                                 business located at 4 Science Park, New Haven,
                                 Connecticut, Telephone (203) 498-4210,
                                 Telecopier (203) 498-4211

                                                (hereinafter, the "COMPANY") and

T W DOYLE CONSULTING INC.        a Connecticut corporation, having a place of
                                 business located at 5 Wellsweep Lane,
                                 Killingworth CT 06419-1384, Telephone (860)
                                 663-2342

                                                          (hereinafter, "TWDC").

WHEREAS TWDC is willing to provide the Company with consulting services pursuant
to the terms of this Agreement and Company is willing to receive such services.

NOW, THEREFORE, TWDC and the Company hereby agree as follows:

1.   Consulting Services.

     (a) Description of Services. The Company hereby contracts with and retains
TWDC to obtain its services as a consultant to the Company to act in such
capacities and to perform such services, and at such times, as are reasonably
pre-authorized by the Company. TWDC's services hereunder shall be rendered
through the services of Terrence Doyle, Ph.D. ("CONSULTANT"). Consultant shall
perform certain services to the Company, at the Company's request, to assist in
the search, evaluation and institution of discovery and pre-clinical development
programs (the "SERVICES") in the field of anti-cancer compounds being pursued by
the Company during the term of this agreement (the "COMPANY'S FIELD OF
RESEARCH").

     (b) Availability of the Consultant. TWDC and the Company mutually agree
that Consultant shall be available to work on the Company's projects at the
discretion of the Company. Travel time incurred by Consultant in connection with
travel pre-authorized by the Company shall be deemed time spent on the Company's
projects. Travel time incurred by Consultant to and from New Haven county,
including to and from the Company's place of business, shall not be billable to
the Company. Consultant shall devote his best efforts, consistent with the terms
and provisions hereof, to performing the Services.

2.   Term and Expiration.

     (a) Term. The term of this Agreement shall become effective on the
Effective Date, and remain in effect until March 31, 2008, subject to earlier
termination as provided herein. The term of this Agreement may be renewed by
mutual consent of both parties for one additional year by written amendment.

     (b) Termination. Notwithstanding Paragraph 2(a), either party may terminate
this Agreement at any time upon thirty (30) days prior written notice to the
other. In addition, if Consultant's employment with TWDC is terminated for any
reason, including physical or mental disability or death, TWDC shall notify the
Company of such termination and this Agreement shall terminate immediately
effective upon termination of Consultant's employment.

     (c) Payment upon Termination. Upon termination, the Company shall be
obligated to pay, within five (5) days of the effective date of termination, all
amounts owing to TWDC for Services completed prior to the termination date and
related expenses, if any, in accordance with the provisions of Paragraph 3
(Compensation) hereof.

3.   Compensation.

     (a) Fees. For all services provided hereunder, the Company shall pay TWDC
at the rate of $150.00 per hour of services performed by Consultant (the
"FEES"). The hourly fee rate will be reviewed annually and adjusted to reflect
any increases or decreases due to inflation as measured by the Consumer Price
Index. Consultant will notify the Company in writing of any such rate adjustment
in advance of providing services to be billed at the adjusted rate. TWDC shall
send a monthly itemized invoice of time spent by Consultant on the Company's
projects to the Company after provision of Services. Invoices and any other
written notices shall be sent to the attention of Karen Schmedlin, c/o Vion
Pharmaceuticals, Inc., 4 Science Park, New Haven, CT 06511. Payment shall be due
within twelve (12) days of the Company's receipt of such invoice. Payments will
be made via wire transfer in U.S. funds.

     (b) Expenses. The Company shall reimburse Consultant for any business and
reasonable travel and related expenses incurred by Consultant in connection with
the Services to be provided by Consultant at any location other than TWDC's
facility, provided that the travel is pre-authorized by the Company, that
Consultant arranges economy airfare through the Company's designated travel
agent, and that all such expenses are properly documented using the Company's
travel and expense report and supported by receipts.

     (c) Taxes. The parties agree that Consultant is an employee of TWDC and
will not be classified or treated as an employee the Company for any purpose.
TWDC shall file, on a timely basis, all income and employment tax returns and
make any withholdings and payments required to be made under applicable law with
respect to the amounts provided to Consultant as compensation for the services
provided hereunder. Neither party, nor such party's directors, officers,
employees or agents, shall bind or make any commitment on behalf of the other
party.

                                        2

4.   Property of the Company.

     (a) Definition. For the purposes of this Agreement, the term "INVENTIONS"
shall mean all discoveries, inventions, improvements, developments, products,
processes, procedures, techniques, formulae, works, computer programs, drawings,
designs, notes, documents, information and materials, whether or not protectable
by copyright, patent or trademark or as a trade secret, made, conceived,
developed or reduced to practice by Consultant, alone or with others.

     (b) Ownership; Assignment of Ownership and Confidentiality.

          (i) Proprietary Information and Inventions Agreement. TWDC and the
     Company agree that they are each bound by the terms and conditions of the
     Confidentiality Disclosure Agreement, attached hereto as Schedule A, and
     that Consultant shall be required to execute same before commencing the
     Services.

          (ii) Ownership. TWDC acknowledges and agrees that the Company shall
     have the sole right to any and all right, title and interest in and to all
     Inventions related to the Company's Field of Research including but not
     limited to, all copyrights, patent rights, trade secret rights and
     trademark rights related thereto,

          (iii) Assignment. Any and all right, title and interest in and to all
     Inventions, including but not limited to, all copyrights, patent rights,
     trade secret rights and trademark rights related thereto, developed in the
     course of performing Services under this Agreement are the sole property of
     the Company. Such Inventions conceived or reduced to practice by the
     consultant shall be, to the extent permitted by law, "works made for hire"
     and TWDC shall assign any and all rights in such Inventions to the Company.
     The Company shall have the sole right to determine the treatment of such
     Inventions, including the right to keep them as trade secrets, to file and
     execute patent applications on them, to use and disclose them without prior
     patent application, to file registrations for copyrights or trademarks on
     them in its own name, or to follow any other procedure that the Company
     deems appropriate.

          (iv) Expenses. The Company shall pay for all expenses in connection
     with any assignment of Inventions by TWDC in accordance with clause (iii)
     above and any assistance provided by Consultant at the Company's request to
     protect the Company's rights in any Inventions. Other than such acts as are
     reasonably required for any assignment of Inventions in accordance with
     clause (iii) above, TWDC shall not be required to take any legal or other
     actions for the benefit of the Company.

5. Indemnification. TWDC hereby agrees to indemnify and hold harmless the
Company and its directors, officers, stockholders, agents and employees, from
and against all claims, liabilities, losses, damages, and expenses as incurred
(including reasonable legal fees), joint or several (including actions or
proceedings in respect thereof) (collectively "Losses"), relating to or arising
out of its or Consultant's

                                        3

performance of the Services, resulting from TWDC or Consultant's gross
negligence, wilful misconduct or bad faith in connection with the Services. The
Company hereby agrees to indemnify and hold harmless TWDC and its directors,
officers, stockholders, agents and employees (including Consultant), from and
against all Losses, relating to or arising out of the Services or any
transaction or matter which is related to the subject matter of the Services,
resulting from the Company's gross negligence, wilful misconduct or bad faith in
connection with the Services.

6. Solicitation of Employment. During the term of this Agreement and for a
period of two (2) years thereafter, (a) TWDC agrees not to solicit or encourage
any employee of the Company to leave the Company or to devote less than all of
such employee's efforts to the Company and (b) the Company shall not solicit or
encourage any employee of TWDC to leave TWDC or to devote less than all of such
employee's efforts to TWDC.

7. Survival of Obligations. The obligations of Paragraphs 2(c), 3, 4, 5 and 6
hereof will survive any expiration or earlier termination of this Agreement.

8. Remedies. In the event of any violation of provisions of Paragraphs 4, 5 or 6
hereof, the Company shall have the right, in addition to any other rights it may
have, to obtain in any court of competent jurisdiction injunctive relief to
restrain such breach or threatened breach.

9. Notices. Any notice required or permitted hereunder shall be given in writing
and shall be deemed effective if given as follows: (a) upon personal delivery;
(b) three (3) days after deposit in the mail by certified or registered mail
(return receipt requested); (c) one (1) business day after deposit with any
return receipt express courier (prepaid); or (d) one (1) business day after
transmission by telecopier, addressed to the other party at its address (or
facsimile number, in the case of transmission by telecopier) as shown above, or
to such other address as such party may designate in writing from time to time
to the other party.

10. Governing Law; Severability. This Agreement shall be governed by and
construed and enforced in accordance with the laws of the State of Connecticut,
regardless of its or any other jurisdiction's conflicts of laws provisions. If
any provision of this Agreement is determined by a court of law to be illegal,
invalid or unenforceable, then such provision shall be enforced to the maximum
extent possible and the other provisions shall remain in full force and effect.

11. Complete Understanding; Modification. This Agreement (including any exhibits
or schedules hereto) constitutes the full and complete understanding of the
parties hereto and supersedes all prior understanding and agreements. Any
waiver, modification or amendment of any provision of this Agreement shall be
effective only if in writing and signed by the parties hereto.

                                      * * *

                                        4

IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date first written above.

VION PHARMACEUTICALS, INC.

By: /s/ Alan Kessman
    ----------------
Name: Alan Kessman
Title: CEO

T W DOYLE CONSULTING INC.

By: /s/ Terrence W. Doyle
    ---------------------
Name: Terrence W. Doyle
Title: President

                                        5

                                                                      SCHEDULE A

                             PROPRIETARY INFORMATION
                            AND INVENTIONS AGREEMENT
                            ------------------------

The following confirms an agreement between Terrence W. Doyle and Vion
Pharmaceuticals, Inc., a Delaware corporation (the "Company"). This agreement is
a material part of the consideration for my Consulting Agreement with the
Company:

     1. I recognize that the Company is engaged in a continuous program of
research, development and production in cancer treatment. I also recognize that
the Company possesses or has rights to information which has commercial value in
the Company's business ("Proprietary Information"). For example, Proprietary
Information includes, without limitation, inventions (patentable or otherwise),
improvements, business strategies, product ideas, formulas, processes,
copyrightable or patentable material, schematics, biological material (including
cell lines antibodies, c-DNAs, antisense nucleotides, proteins, vectors, new
chemical entities, media, reagents and related materials) and techniques for
their handling and use, any other confidential or proprietary information of the
Company, or its customers or clients which I may learn of, or be exposed to,
from time to time prior to and during the term of my Consulting Agreement and as
a direct consequence of those activities. Specifically excluded is information
obtained by me as part of other activities not associated with my consulting
activities for Vion

     2. I understand and agree that my Consulting Agreement creates a
relationship of confidence and trust between me and the Company with respect to
(i) all Proprietary Information, and (ii) the confidential information of others
with which the Company has a business relationship. At all times, both during my
Consulting Agreement with the Company and after its termination, I will keep in
confidence and trust all such information, and I will not use or disclose any
such information without the written consent of the Company, except as may be
necessary in the ordinary course of performing my duties to the Company or as
may be required by law. I understand that should I violate this agreement by
disclosing any such Proprietary Information and/or confidential information, the
Company will seek to recover damages by initiating legal action against me and
possibly the party or parties to whom I made the disclosure, and will criminally
prosecute under the Economic Espionage Act of 1996.

                                        1

     3. In addition, I hereby agree as follows:

     (a) All Proprietary Information disclosed to me in consequence of my
consulting as defined in this agreement and the Consulting Agreement dated April
1, 2006, shall be the sole property of the Company and its assigns, and the
Company and its assigns shall be the sole owner of all trade secrets, patents,
copyrights, and other rights in connection therewith. I hereby assign to the
Company any rights I may have or acquire in such Proprietary Information.

     (b) All documents, records, apparatus, equipment and other physical
property whether or not pertaining to Proprietary Information, furnished to me
by the Company or produced by me or others in connection with my Consulting
Agreement shall be and remain the sole property of the Company. I shall return
to the Company all such materials and property as and when requested by the
Company. Even if the Company does not so request, I shall return all such
material and property upon the termination of the Consulting Agreement by me or
by the Company for any reason, and I will not take with me any such material or
property or any reproduction thereof upon such termination.

     (c) I will promptly disclose to the Company, or any persons designated by
it, all improvements, inventions, works or authorship, formulas, ideas,
processes, techniques, know-how and data, whether or not patentable
(collectively, "Inventions"), made or conceived, reduced to practice or learned
by me, either alone or jointly with others, during the term and as a direct
consequence of my Consulting during the term of and as defined by this agreement
and the Consulting Agreement dated April 1, 2006.

     (d) All Inventions which I conceive, develop or have developed (in whole or
in part, either alone or jointly with others) and (i) use or have used
equipment, supplies facilities or trade secret information of the Company, or
(ii) use or have used the hours for which I am to be or was compensated by the
Company, or (iii) which relate at the time of conception or reduction to
practice thereof to the business of the Company or to its actual or demonstrably
anticipated research and development (iv) which result from any work performed
by me for the Company shall be the sole property of the Company and its assigns
(and to the fullest extent permitted by law shall be deemed works made for
hire), and the Company and its assigns shall be the sole owner of all patents,
copyrights and other rights in connection therewith. I hereby assign to the
Company any rights I may have or acquire in such Inventions. I agree that any
Invention required to be disclosed under paragraph (c) above during the term of
my Consulting Agreement shall be presumed to have been conceived during the term
of my Consulting Agreement with the Company. I understand that I may overcome
the presumption by showing that such Invention was conceived after the
termination of my Consulting Agreement.

     (e) With respect to Inventions described in paragraph (d) above, I will
assist the Company in every proper way (but at the Company's expense) to obtain
and from time to time enforce patents, copyrights or other rights on said
Inventions in any and all countries, and will execute all documents reasonably
necessary or appropriate for this purpose. This obligation shall survive the
termination of my Consulting Agreement, but the Company shall compensate me at a
reasonable rate after such termination for time actually spent by me at the

                                        2

Company's request on such assistance. In the event that the Company is unable
for any reason whatsoever to secure my signature to any document reasonably
necessary or appropriate for any of the foregoing purposes, (including renewals,
extensions, continuations, divisions or continuations in part), I hereby
irrevocably designate and appoint the Company and its duly authorized officers
and agents, as my agents and attorneys-in-fact to act for and in my behalf and
instead of me, but only for the purpose of executing and filing any such
document and doing all other lawfully permitted acts to accomplish the foregoing
purposes with the same legal force and effect as if executed by me.

     (f) So that the Company may be aware of the extent of any other demands
upon my time and attention, I will disclose to the Company (such disclosure to
be held in confidence by the Company) the nature and scope of any other business
activity in which I am or become engaged during the term of my Consulting
Agreement, and I will not engage in any business activity which is related to
the Company's business or its actual or demonstrably anticipated research and
development.

     (g) I will not now or in the future disrupt, damage, impair or interfere
with the business of the Company, whether by way of interfering with or raiding
its employees, disrupting its relationships with customers, agents, vendors,
distributors or representatives, or otherwise. During the term of my Consulting
Agreement with the Company and for a period of one year after termination of my
Consulting Agreement, I agree not to solicit any employees of the Company to
work for an employer which competes with the Company. I understand that I am not
restricted from being employed by or engaged in a competing business after
termination of my Consulting Agreement by the Company.

     (h) It is understood that the Consultant will make the Company aware of any
academic activities which may be related to the interests of the Company but
this agreement will in no way constrain the Consultant's usual and normal
academic pursuits.

     4. I represent that my execution of this Agreement, my Consulting Agreement
with the Company and my performance of my proposed duties to the Company in the
development of its business will not violate any obligation I may have to any
present or former employer, including any obligation to keep confidential any
proprietary or confidential information of any such employer. I have not entered
into, and I will not enter into, any agreement which conflicts with or would, if
performed by me, cause me to breach this Agreement.

     5. In the course of performing my duties to the Company, I will not utilize
any proprietary or confidential information of any present or former employer.

     6. I agree that this Agreement does not constitute an employment
relationship or agreement and that, unless otherwise provided in a written
contract signed by both the Company and me, (i) my relationship with the Company
is as an independent contractor, and (ii) I shall have the right to terminate my
independent contractor relationship,

                                        3

and the Company shall have the right to terminate my independent contractor
relationship, under the terms and conditions of the Consulting Agreement, with
or without cause.

     7. This Agreement shall be effective on the date signed, shall be binding
upon me, my heirs, executors, assigns and administrators and shall inure to the
benefit of the Company, its successors and assigns.

Dated  March 31, 2006                              Accepted and Agreed to:
                                                   VION PHARMACEUTICALS, INC.

By: /s/ Terrence W. Doyle                          By: /s/ Alan Kessman
    ---------------------                              ----------------
    Terrence W. Doyle                                  Alan Kessman
                                                       CEO

                                        4

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