Document:

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                                                                    EXHIBIT 4.16

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                            ECHOSTAR DBS CORPORATION

                          10 3/8% SENIOR NOTES DUE 2007

                          FIRST SUPPLEMENTAL INDENTURE

                          Dated as of December 31, 2003

                         U.S. Bank National Association

                                     Trustee

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                  FIRST SUPPLEMENTAL INDENTURE, dated as of December 31, 2003
(the "Supplemental Indenture"), among EchoStar DBS Corporation, a Colorado
corporation (the "Company"), EchoStar Satellite Operating Corporation, a
Colorado corporation (the "New Guarantor"), and U.S. Bank National Association,
as trustee (the "Trustee"), to the indenture, dated as of November 12, 2002 (the
"Original Indenture"), by and between the Company, the Guarantors (as defined in
the Original Indenture) and the Trustee, for the 10 3/8% Senior Notes due 2007
(the "Notes") of the Company.

                                    RECITALS

                  The Company, the Guarantors and the Trustee have heretofore
executed and delivered the Original Indenture providing for the issuance of the
Notes.

                  The Company or one of the Guarantors has determined to
transfer property or assets to the New Guarantor.

                  Pursuant to Section 4.13 of the Original Indenture, the
Company and the New Guarantor have duly authorized the execution and delivery of
this Supplemental Indenture to provide for the addition of the New Guarantor to
the list of Guarantors under the Original Indenture.

                  New Guarantor has executed and delivers herewith the guarantee
(the "New Guarantee") attached hereto as Exhibit A.

                  All things necessary (i) to make the New Guarantee when
executed by the New Guarantor and delivered hereunder the valid obligations of
the New Guarantor and (ii) to make this Supplemental Indenture a valid agreement
of the Company and the New Guarantor, all in accordance with their respective
terms, have been done.

                  In consideration of the premises and the covenants and
agreements contained herein, and for other good and valuable consideration the
receipt of which is hereby acknowledged, it is mutually agreed as follows for
the equal and ratable benefit of the Holders of the Notes.

Section 1.        Additional Subsidiary Guarantee.

                  Pursuant to Section 4.13 of the Original Indenture, New
Guarantor is hereby made a party to the Original Indenture as a "Guarantor", and
as a "Guarantor" the New Guarantor unconditionally guarantees all of the
Company's obligations under the Notes on the terms set forth in the Original
Indenture.

Section 2.        Effect on the Original Indenture.

                  Except as amended by this Supplement Indenture, the Original
Indenture shall remain in full force and effect and is hereby ratified and
confirmed.

Section 3.        Governing Law.

                  The internal law of the State of New York shall govern and be
used to construe this Supplemental Indenture and the New Guarantee.

                                       1
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Section 4.        Defined Terms.

                  Unless otherwise indicated, capitalized terms used in this
Supplemental Indenture and not defined shall have the respective meanings
assigned to them in the Original Indenture.

Section 5.        Counterpart Originals.

                  The parties may sign any number of copies of this Supplemental
Indenture. Each signed copy shall be an original, but all of them together
represent the same agreement.

Section 6.        Effect of Headings.

                  Section headings herein are for convenience only and shall not
affect the construction hereof.

Section 7.        Severability.

                  In case any provision in this Supplemental Indenture shall be
invalid, illegal or unenforceable, the validity, legality and enforceability of
the remaining provisions shall not in any way be effected or impaired thereby.

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                  IN WITNESS WHEREOF, the parties hereto have caused this
Supplemental Indenture to be duly executed as of the day and year first above
written.

                                       ECHOSTAR DBS CORPORATION,
                                         a Colorado corporation

                                       By: /s/ David K. Moskowitz
                                          --------------------------------------
                                          Name:  David K. Moskowitz
                                          Title: Senior Vice President

                                       U.S. BANK NATIONAL ASSOCIATION,
                                         as Trustee

                                       By: /s/ Richard H. Prokosch
                                          --------------------------------------
                                          Name:  Richard H. Prokosch
                                          Title: Vice President

                                       ECHOSTAR SATELLITE OPERATING CORPORATION,
                                         as New Guarantor

                                       By: /s/ David K. Moskowitz
                                          --------------------------------------
                                          Name:  David K. Moskowitz
                                          Title: Senior Vice President

<PAGE>
                                                                       Exhibit A

                                    GUARANTEE

                  EchoStar Satellite Operating Corporation and its successors
under the Indenture, dated as of November 12, 2002 (the "Indenture"), among
EchoStar DBS Corporation (the "Company"), the Guarantors (as defined in the
Indenture, as supplemented) and U.S. Bank National Association (the "Trustee"),
for the 10 3/8% Senior Notes due 2007 (the "Notes") of the Company, jointly and
severally with any other Guarantors, hereby irrevocably and unconditionally
guarantees (i) the due and punctual payment of the principal of, premium, if
any, and interest on the Notes, whether at maturity, by acceleration or
otherwise, the due and punctual payment of interest on the overdue principal of
and interest, if any, on the Notes, to the extent lawful, and the due and
punctual performance of all other obligations of the Company to the Holders or
the Trustee all in accordance with the terms set forth in Article 10 of the
Indenture, (ii) in case of any extension of time of payment or renewal of any
Notes or any of such other obligations, that the same will be promptly paid in
full when due or performed in accordance with the terms of the extension or
renewal, whether at stated maturity, by acceleration or otherwise and (iii) has
agreed to pay any and all costs and expenses (including reasonable attorneys'
fees) incurred by the Trustee or any Holder in enforcing any rights under this
Guarantee. Capitalized terms used herein have the meanings assigned to them in
the Indenture, as amended and supplemented, unless otherwise indicated.

                  No stockholder, officer, director or incorporator, as such,
past, present or future, of EchoStar Satellite Operating Corporation shall have
any personal liability under this Guarantee by reason of his or its status as
such stockholder, officer, director or incorporator. This Guarantee shall be
binding upon EchoStar Satellite Operating Corporation and its successors and
assigns and shall inure to the benefit of the successors and assigns of the
Trustee and the Holders and, in the event of any transfer or assignment of
rights by any Holder or the Trustee, the rights and privileges herein conferred
upon that party shall automatically extend to and be vested in such transferee
or assignee, all subject to the terms and conditions hereof.

                  This Guarantee shall not be valid or obligatory for any
purpose until the certificate of authentication on the Note upon which this
Guarantee is noted shall have been executed by the Trustee under the Indenture
by the manual signature of one of its authorized officers.

                  THE TERMS OF ARTICLE 10 OF THE INDENTURE ARE INCORPORATED
HEREIN BY REFERENCE.

                  This Guarantee shall be governed by and construed in
accordance with the laws of the State of New York.

                                        ECHOSTAR SATELLITE OPERATING
                                        CORPORATION

                                        By: /s/ David K. Moskowitz
                                           -------------------------------------
                                           Name:  David K. Moskowitz
                                           Title: Senior Vice Presidentexv10w008

 

Exhibit 10.008

LEASE TERMINATION AGREEMENT

     This LEASE TERMINATION AGREEMENT (the “Agreement”) is made and entered
into as of the 15 day of October, 2003, by and between Cygnus, Inc., a
Delaware corporation (“Tenant”) and Metropolitan Life Insurance Company, a New
York corporation (“Landlord”).

Recitals:

     A. Metropolitan’s predecessor in interest as Landlord (Seaport Centre
Venture Phase I, a California general partnership, herein, the “Venture”) and
Tenant’s predecessor in interest as Tenant (Cygnus Research Corporation, a
California corporation) entered into that certain written Lease dated September
27, 1988 (the “Original Lease”), for certain premises of approximately 20,880
square feet of space in Building 8 of Phase I (“Building 8 Space”), located at
701 Galveston Street, Redwood City, California, all as more particularly
described in the Original Lease, which Original Lease included Rider No. 1 To
Seaport Centre Standard Lease and Exhibits A, A-1, B & C.

     B. The Venture and Tenant’s predecessor in interest as Tenant at the time
(then, Cygnus Therapeutic Systems, a California corporation) entered into that
certain written First Amendment To Ten-Year Industrial Net Lease Agreement
dated May 15, 1992 (the “First Amendment”) for certain space in Building 5 of
Phase I (“Building 5 Space”), and that certain written Second Amendment To
Ten-Year Industrial Net Lease Agreement dated August 8, 1992 (the “Second
Amendment”) for certain space of approximately 11,158 square feet in Building 3
of Phase I (“Building 3 Space”), whose current street address remains 501
Chesapeake Street, Redwood City, California.

     C. Landlord and Tenant entered into that certain written Third Amendment
to Ten-Year Industrial Net Lease Agreement dated as of June 8, 1998 (the “Third
Amendment”) pursuant to which the expiration of the lease for Building 5 was
acknowledged.

     D. Landlord and Tenant entered into that certain written Fourth Amendment
to Ten-Year Industrial Net Lease Agreement dated as of October 18, 2002 (the
“Fourth Amendment”).

     E. The Original Lease, as amended prior to this Amendment, is referred to
as the “Existing Lease”. The “Existing Premises”, prior to this Amendment,
shall mean the “Building 3 Space” (as defined in the Third Amendment,
approximately 11,158 square feet in Building 3 of Phase I, whose current street
address remains 501 Chesapeake Street, Redwood City, California) as further
described on Exhibit A.

     F. Tenant subleases the Building 3 Space to Maxygen, Inc. (“Maxygen”)
pursuant to that certain Sublease between Tenant and Maxygen dated as of March
30, 2001 (the “Sublease”) and desires to surrender the Building 3 Space to
Landlord. Landlord and Tenant desire to provide for (i) Tenant’s surrender of
the Building 3 Space; and (ii) termination of the Existing Lease, in strict
accordance with the terms and conditions set forth herein.

     NOW THEREFORE, in consideration of the mutual terms and conditions herein
contained, the parties hereby agree as follows:

     1. Initial Provisions.

     (a) Definitions. Unless otherwise defined herein, all capitalized terms
have the meanings ascribed to them in the Existing Lease.

     (b) Condition Precedent. This Agreement and the obligations of each
party hereunder are expressly subject to the condition precedent of Landlord
successfully entering into and obtaining a legally binding new written lease
with Codexis, Inc. (“Codexis”) for the Existing Premises satisfactory in all
respects in form and substance to Landlord, in Landlord’s sole discretion (the
“Codexis Lease”). If such condition precedent is not satisfied, unless waived
in writing by Landlord in its sole discretion, this Amendment shall be null and
void, and of no force or effect, and the Existing Lease shall remain in full

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force and effect unmodified by this Agreement. Landlord shall give Tenant
written notice of the satisfaction of this condition precedent or of Landlord’s
written waiver of this condition precedent.

     2. Termination. The Term of the Lease is hereby amended to terminate and
expire on the 15th day of October, 2003 (the “Effective Date”). Any and all
options and rights of Tenant to extend the Term or expand the Existing Premises
are hereby terminated and of no further force or effect. On the Effective
Date, the Existing Premises shall be surrendered by Tenant. Tenant shall fully
comply with all obligations under the Existing Lease through the Effective
Date, including, without limitation, those provisions relating to the condition
of the Existing Premises, and the return of possession of the Existing Premises
as set forth in Article Twenty-Eight of the Existing Lease. On or before the
Effective Date, Tenant shall deliver to Landlord any plans and specifications,
maintenance records, permits, and licenses pertaining to the Existing Premises
or to any improvements thereon, or to both (but not pertaining to Tenant’s
business conducted therein) in the possession of Tenant.

     Notwithstanding anything to the contrary contained in the Existing Lease, it is
understood and agreed that Tenant shall have the following restoration
obligations (collectively, the “Restoration Obligations”): (a) Tenant shall
remove from the Existing Premises, the Building and the Project all signs
relating to the identity of the occupant and/or the business conducted in the
Existing Premises, and shall restore each affected area to its condition prior
to the installation of such signs, at Tenant’s sole cost and expense; (b)
Tenant shall remove from the Existing Premises those items described in the
Existing Lease, including without limitation, Article 28 of the Original Lease,
and shall restore the Existing Premises as described in the Existing Lease,
except if and to the extent otherwise specified on Exhibit B, at Tenant’s sole
cost and expense; and (c) those items specified on Exhibit C attached hereto
and made a part hereof (the “Codexis Improvements”) shall be the sole and
exclusive property of Codexis, Inc., who will be the new tenant of the Existing
Premises, subject to the terms of its lease with Landlord and Tenant hereby
acknowledges that, on the Effective Date or earlier termination of the Existing
Lease, Tenant shall have no interest in the Codexis Improvements. The parties
hereto agree that a final walkthrough of the Existing Premises shall be
conducted by Tenant, Landlord and Subtenant (as described in the Joinder below)
at a mutually agreeable time and Exhibits B and C are subject to modification
following said walkthrough.

     3. Payments; Consideration; Security Deposit. Tenant shall continue to
pay all Rent and other charges under the Lease accruing through the Effective
Date, all of which shall be prorated through the Effective Date in accordance
with Article Five of the Existing Lease and as provided herein. Any
undetermined Rent and other charges may be billed to Tenant when determined
(and Tenant’s obligation to pay the same shall survive termination of the
Existing Lease), or Landlord may reasonably estimate such charges and require
that Tenant pay the same within ten (10) days after Landlord bills the same,
subject to adjustment after the actual Rent and other charges have been
determined. Tenant agrees to indemnify and hold Landlord harmless against any
utility charges or other charges relating to the Existing Premises resulting
from contracts between Tenant and utility suppliers which are the obligation of
Tenant under the Existing Lease and which accrue on or before the Effective
Date. As additional consideration for this Agreement, and to cover Landlord’s
administrative, processing and legal fees, and to reimburse Landlord for any
loss of rentals that may hereafter be sustained after the Effective Date as a
result of this Agreement:

(a) Tenant shall pay the amount of Fifty Thousand Three Hundred
Forty-Three and 21/100 Dollars ($50,343.21) in cash or certified
funds, as additional Rent under the Lease, on or before the
Effective Date and Tenant shall forward such sums as it received
from Subtenant pursuant to the Joinder below; and

(b) Tenant shall pay Landlord any rent tax, sales tax, service tax
or other tax, if any, due on the foregoing amounts.

     4. Release. In consideration of Landlord executing this Agreement, except
to the extent of Landlord’s obligations expressly set forth in this Agreement,
Tenant hereby releases and forever discharges Landlord, and its partners,
officers, directors, agents, property manager, trustees, beneficiaries, and
employees (collectively, “Releasees”), of and from any and all claims, acts,
damages,

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demands, rights of action and causes of action which Tenant ever had, now has,
or in the future may have, against Releasees, arising from or in any way
connected with the Existing Lease, or Landlord’s management or operation of the
Building (those matters and only those above-described matters released by
Landlord and Tenant respectively are referred to collectively as the “Released
Matters”). Tenant understands and agrees that by Landlord’s execution of this
Agreement, Releasees do not admit any liability of any nature whatsoever. This
Agreement is made entirely as a compromise and for the purpose of terminating
the Lease.

“With respect to the Released Matters, both parties expressly waive any
and all rights which they may have under Section 1542 of the Civil Code
of the State of California, which provides as follows:

A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES
NOT KNOW OR SUSPECT TO EXIST IN HIS FAVOR AT THE TIME OF EXECUTING
THE RELEASE, WHICH IF KNOWN BY HIM MUST HAVE MATERIALLY AFFECTED
HIS SETTLEMENT WITH THE DEBTOR.”

     5. Representations.

     (a) Each party represents to the other that it has full power and
authority to execute this Agreement.

     (b) Tenant represents that:

(i) It has not made any assignment, sublease, transfer, conveyance
or other disposition of the Existing Lease or any interest in the
Existing Lease or the Existing Premises, and has no knowledge of
any existing or threatened claim, demand, obligation, liability,
action or cause of action arising from or in any manner connected
with the Existing Lease or the Existing Premises by any other
party;

(ii) All subleases, concessions, and other rights of use and
occupancy of the Existing Premises, insurance policies, and
maintenance and service contracts which Landlord has not previously
elected in writing to continue, if any, have been legally
terminated or will be terminated prior to the Effective Date. No
cause of action against Landlord exists as of the date of this
Agreement nor will exist in the future in any party to a sublease,
concession, agreement for use or occupancy, or insurance policy or
maintenance or service contract, based on the breach of any
contract or obligation arising from the termination of the Existing
Lease;

(iii) There are no outstanding contracts for the supply of labor or
material as of the date of this Agreement, and no work has been
done or is being done, nor have materials been delivered in, about,
or to the Existing Premises which has or have not been fully paid
for, for which a mechanics’ lien could be asserted and/or
foreclosed under the lien laws of the State of California;

(iv) Tenant is the owner of the entire interest of tenant pursuant
to the Existing Lease subject to no liens, claims or encumbrances,
except for the claims, if any, of the Subtenant under the Sublease;

(v) The Existing Premises are now and will on the Effective Date be
clean and in good order, condition and repair, reasonable wear and
tear excepted; and

(vi) No litigation arising out of or in any way connected with
Tenant’s interest under the Existing Lease or occupancy of the
Existing Premises is pending or threatened.

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     (c) The obligations of each party with respect to its representations and
warranties under this Section survive the expiration or sooner termination of
the Term of the Existing Lease.

     6. Holding Over. Any holding over of possession of the Existing Premises
or any part thereof by Tenant after the Effective Date shall be governed by the
provisions of Article Thirty-six of the Existing Lease. The foregoing
provisions shall not serve to extend the Term (although Tenant shall be bound
to comply with all provisions of the Existing Lease until Tenant vacates
Existing Premises).

     7. No Release of Accrued Obligations. Neither this Agreement nor the
acceptance by Landlord of the Existing Premises and the termination of the
Lease shall in any way:

(a) be deemed to excuse or release Tenant from any obligation or
liability, including without limitation any obligation or liability
under provisions of the Existing Lease to indemnify, defend and
hold harmless Landlord or other parties, or with respect to any
breach or breaches of the Existing Lease, which obligation or
liability (i) first arises on or prior to the date Tenant ceases to
use or hold possession of part or all of the Existing Premises or
(ii) arises out of or is incurred in connection with events or
other matters which took place on or prior to the date Tenant
ceases to use or hold possession of part or all of the Existing
Premises, or

(b) affect any obligation under the Existing Lease which by its
terms is intended to survive the expiration or sooner termination
of the Existing Lease.

     8. Contingency Regarding Termination Fee. If any payment, or any part
thereof, made in connection with this Agreement or the Existing Lease is
subsequently invalidated, declared to be fraudulent or preferential, set aside
or avoided and/or required to be rescinded or returned by the Landlord for any
reason whatsoever (including, but not limited to, the insolvency, bankruptcy or
reorganization of Tenant) then the release of Tenant by Landlord will, at the
election of Landlord, be voided as if never made, and the liability of Tenant
to Landlord for loss of Rent and other damages caused by Tenant’s default under
the Existing Lease shall not be limited or released by this Agreement and shall
be revived, reinstated and restored, and shall exist as if this Agreement had
not compromised and limited such liability, and in such event the Existing
Lease and Tenant’s right to possession of the Existing Premises shall remain
terminated as of the Effective Date and then Landlord’s claims and remedies
against Tenant shall be for the full amount of monetary damages caused by
Tenant’s default under the Existing Lease as would be recoverable under Section
1951.2 of the California Civil Code upon abandonment of the Existing Premises
by Tenant as of the Effective Date and/or termination of the Existing Lease as
of the Effective Date because of Tenant’s default.

     9. Brokerage. Each of Landlord and Tenant respectively represents and
warrants to the other that neither it nor anyone acting on its behalf has dealt
with any real estate broker or finder who might be entitled to a commission
based upon the subject matter of this Agreement and no discussions or
negotiations were had with any broker or finder concerning the subject matter
of this Agreement. Each of Landlord and Tenant respectively agrees to
indemnify and defend the other against and hold the other harmless from any
claims of brokerage commissions arising out of any discussions or negotiations
allegedly had by the indemnifying party with any other broker or brokers in
connection with this Agreement.

     10. Notices. All bills, statements, consents, notices, requests, demands
or communications which either party may desire or be required to give to the
other hereunder shall be in writing and delivered to the other party at the
addresses and by one of the methods provided under the Existing Lease.

     11. Waiver. No failure or delay by a party to insist upon the strict
performance of any term, condition or covenant of this Agreement, or to
exercise any right, power or remedy hereunder shall constitute a waiver of the
same or any other term of this Agreement or preclude such party from enforcing
or exercising the same or any such other term, conditions, covenant, right,
power or remedy at any later time.

4

 

     12. Agreement to Perform Necessary Acts. Each party agrees that upon
demand therefor, it shall promptly perform all further acts and execute,
acknowledge and deliver all further instructions, instruments and documents
which may be reasonably necessary or useful to carry out the provisions of this
Agreement or to evidence, perfect or otherwise effectuate the rights and
remedies relating to this Agreement.

     13. Attorneys’ Fees; Costs of Dispute Resolution. Each party to this
Agreement agrees to bear its own attorneys’ fees and costs incurred in
connection with the discussions preceding, negotiations for and documentation
of this Agreement. In the event any party brings any suit or other proceeding
with respect to the subject matter or enforcement of this Agreement or the
Existing Lease as amended by this Agreement, the prevailing party (as
determined by the court, agency or other authority before which such suit or
proceeding is commenced) shall, in addition to such other relief as may be
awarded, be entitled to recover attorneys’ fees, expenses and costs of
investigation as actually incurred (including without limitation court costs,
expert witness fees, costs and expenses of investigation, and all attorneys’
fees, costs and expenses in any such suit or proceeding, including without
limitation in any action or participation in or in connection with any case or
proceeding under the Bankruptcy Code, 11 United States Code Sections 101 et
seq., or any successor statutes, in establishing or enforcing the right to
indemnification, in appellate proceedings, or in connection with the
enforcement or collection of any judgment obtained in any such suit or
proceeding).

     14. No Disclosure. Tenant agrees that it shall not disclose any of the
matters set forth in this Agreement or disseminate or distribute any
information concerning the terms, details or conditions hereof to any person,
firm or entity without obtaining the express written approval of Landlord.

     15. No Offer. This Agreement shall not be binding until executed and
delivered by both parties. This Agreement shall not be relied upon by any
other party, individual, corporation, partnership or other entity as a basis
for terminating its lease with Landlord.

     16. Whole Agreement. The mutual obligations of the parties as provided
herein are the sole consideration for this Agreement, and no representations,
promises or inducements have been made by the parties other than as appear in
this Agreement. This Agreement may not be amended except in writing signed by
both parties.

     17. Severability. If any provision of this Agreement or the application
thereof to any person or circumstances shall be invalid or unenforceable to any
extent, the remainder of this Agreement and the application of such provision
to other persons or circumstances, other than those to which it is held
invalid, shall not be affected thereby and shall be enforced to the furthest
extent permitted by law, provided that the invalidity of such provision does
not materially affect the benefits accruing to any party hereto.

     18. Memorandum of Mutual Cancellation of Lease. Notwithstanding any
provision of the Lease to the contrary, along with Tenant’s delivery to
Landlord of this Agreement signed by Tenant, Tenant shall deliver to Landlord
triplicate originals of a signed and notarized Memorandum of Mutual
Cancellation of Lease in the form attached hereto as Exhibit D (the “Memorandum
of Termination of Lease”). Landlord shall hold such Memorandum of Termination
of Lease unless and until the condition precedent is satisfied (or waived in
writing by Landlord) as provided in Section 1(b) of this Agreement and the
Effective Date occurs, and thereupon Landlord shall be entitled to execute,
date and record such Memorandum of Termination of Lease in the Official Records
of the County in which the Premises is located. If the condition precedent is
not satisfied or waived in writing by Landlord, then Landlord shall destroy and
dispose of such Memorandum of Termination of Lease.

     19. Miscellaneous. Warranties, representations, agreements, and
obligations contained in this Agreement shall survive the execution and
delivery of this Agreement and shall survive any and all
performances in accordance with this Agreement. This Agreement may be executed
in any number of counterparts which together shall constitute the Agreement.
This Agreement and the terms and provisions hereof shall inure to the benefit
of and be binding upon the heirs, successors and assigns of the parties. This
Agreement shall be construed and enforced in accordance with the laws of the
state in

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which the Building is located. In the event of a conflict between the
terms and provisions of this Agreement and those contained in the Lease, the
terms and provisions of this Agreement shall control.

     20. Counterparts. This Amendment may be executed in duplicates or
counterparts, or both, and such duplicates or counterparts together shall
constitute but one and the same instrument. Each duplicate and counterpart
shall be equally admissible in evidence, and each original shall fully bind
each party who has executed it. The parties contemplate that they may be
executing counterparts of this Amendment transmitted by facsimile and agree and
intend that a signature by facsimile machine shall bind the party so signing
with the same effect as though the signature were an original signature.

     IN WITNESS WHEREOF, the parties have executed this Agreement as of the
date first above written.

	 	 	 	 	 
	TENANT:         	Cygnus, Inc.,

a Delaware corporation

 	 
	 	By:  	/s/   Craig W. Carlson
 	 
	 	 	Print Name:  	 Craig W. Carlson 	 
	 	 	Title:  	Sr VP, CFO & COO
	 
	 	 	 	(Chairman of Board, President or Vice President)
	 
	 	 	Date:  	10/22/03 	 
	 
	 	 	 
	 	By:  	               /s/ Barbara G. McClung
 	 
	 	 	Print Name:  	Barbara G. McClung 	 
	 	 	Title:  	Secretary
	 
	 	 	Title:  	(Secretary, Assistant Secretary, CFO or Assistant Treasurer)
	 
	 	 	Date:   	
10/22/03 	 
	 
	LANDLORD:       	Metropolitan Life Insurance Company,

a New York corporation

 	 
	 	By:  	/s/ Joel R. Redmon
 	 
	 	 	Print Name:  	Joel R. Redmon 	 
	 	 	Title:  	Asst VP
	 
	 	 	Date:  	10/29/03 	 
	 

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JOINDER BY SUBTENANT

TO

LEASE TERMINATION AGREEMENT

     Maxygen, Inc. is the Subtenant (the “Subtenant”) under that certain
Sublease between Subtenant and Cygnus, Inc. , as Sublandlord, dated as of March
30, 2001 (the “Sublease”) under which Subtenant subleases from Sublandlord
certain space known as the “Building 3 Space” consisting of approximately
11,158 square feet in Building 3 of Phase I of Seaport Centre, whose current
street address is 501 Chesapeake Street, Redwood City, California. Subtenant
hereby consents to and joins in the foregoing Lease Termination Agreement and
agrees that its right, title and interest, as Subtenant, in and to the Existing
Premises (as defined in the Lease Termination Agreement) shall be governed by
the terms of the Lease Termination Agreement as if it were the tenant
thereunder, including, but not limited to the provisions of Section 4 thereof.

“With respect to the Released Matters, both parties expressly waive any
and all rights which they may have under Section 1542 of the Civil Code
of the State of California, which provides as follows:

A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE CREDITOR DOES
NOT KNOW OR SUSPECT TO EXIST IN HIS FAVOR AT THE TIME OF EXECUTING
THE RELEASE, WHICH IF KNOWN BY HIM MUST HAVE MATERIALLY AFFECTED
HIS SETTLEMENT WITH THE DEBTOR.”

In addition, Subtenant hereby agrees that:

(a) Subtenant shall pay Sublandlord the amount of FiftySix Thousand
Four Hundred Twenty-Four and 46/100 Dollars ($56,424.46) in cash or
certified funds, as additional Rent under the Sublease, on or
before the Effective Date; and

(b) Subtenant shall pay Sublandlord any rent tax, sales tax,
service tax or other tax, if any, due on the foregoing amounts.

     Dated this 22 day of Oct, 2003.

	 	 	 	 	 
	 	Maxygen, Inc.,

a Delaware corporation

 	 
	 	By:  	/s/ Lawrence W. Briscoe
 	 
	 	Its	CFO 	 
	 	 	 	 
	 

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EXHIBIT A

(Lease Termination Agreement with Cygnus, Inc.)

Building 3 Space

8

 

EXHIBIT B

(Lease Termination Agreement with Cygnus, Inc.)

Restoration Requirements

NONE

9

 

EXHIBIT C

(Lease Termination Agreement with Cygnus, Inc.)

CODEXIS IMPROVEMENTS

501 CHESAPEAKE DRIVE

	 	 	 
	LAB OR AREA
	 	DESCRIPTION OF TENANT IMPROVEMENTS

	BIO-PROCESS

	 	BUILD BIO-PROCESS LAB AND INSTALL PLUMBING, ELECTRICAL HVAC and
COLD ROOM)
	 
	 	 
	REAR OF BLDG.

	 	BUILD ENCLOSURE AND INSTALL A 125 KVA ONAN

EMERGENCY GENERATOR
	 
	 	 
	REAR OF BLDG.

	 	BUILD ENCLOSURE AND INSTALL 2 DOOR HAZARDOUS

MATERIAL CONTAINER

FOR SPECIFIC PLANS SEE “New Lab Remodel Tenant Improvement Project #2001-008;
Architect: Hitech; For Record Drawings Dated 12-12-01 including A-01.0/A4.2,
S-1/S-3, P-0/P-4, M-0/M-2, LA-1.0” AND “Wittmers Electric Inc. Power Plan,
Lighting Plan, Panel Schedule and Roof Plan E-1/E-5 Dated 12-10-01”, AND
“FireStop New Lab Remodel Tenant Improvement #FP-1 dated 7-11-01

AND

     Revised As-Builts for work subsequent to 12-12-01 but before 10-15-03.

10

 

EXHIBIT D

(Lease Termination Agreement with Cygnus, Inc.)

Memorandum of Termination of Lease

RECORDING REQUESTED BY

AND WHEN RECORDED RETURN TO:

Unrecorded Lease, less than 35 years: No Tax Due

MEMORANDUM OF TERMINATION OF LEASE

THIS MEMORANDUM OF TERMINATION OF LEASE (“Memorandum”) is made as of October
   , 2003, by and between Metropolitan Life Insurance Company, a New York
corporation (“Lessor”), and Cygnus, Inc., a Delaware corporation (“Lessee”).

RECITALS

A. Lessor and Lessee entered into that certain unrecorded lease a memorandum of
which is recorded          , 19   in Book    , page    ,
as Instrument No.    ,          Official Records (the “Lease”) with
respect to the real property described in Exhibit A attached hereto (the
“Property”).

B. Lessor and Lessee desire to terminate the Lease as it affects the Property
while preserving certain personal covenants contained in the Lease,NOW,
THEREFORE, the parties agree as follows:

	1.	 	Lessor and Lessee hereby agree and acknowledge that the Lease is
terminated, and is of no further force or effect, effective as of the date
of this Memorandum, subject to paragraph 2 hereof.
	 
	2.	 	This Memorandum shall be binding on and inure to the benefit of the
parties hereto and their heirs, executors, administrators, successors and
assigns.
	 
	3.	 	This Memorandum may be executed in any number of counterparts, each of
which when executed and delivered will be deemed to be an original and all
of which, taken together, will be deemed to be one and the same
instrument.

11

 

	 	 	IN WITNESS WHEREOF, the parties hereto have executed this Memorandum as of
the date first above written.

	 	 	 	 	 
	LESSEE:       	Cygnus, Inc.,

a Delaware corporation

 	 
	 	By:  	/s/ Craig W. Carlson
 	 
	 	 	Print Name:  	Craig W. Carlson 	 
	 	 	Title:  	Sr VP, CFO & COO
	 

	 	 	 	(Chairman of Board, President or Vice President)
	 
	 	 	Date:   	
10/22/03 	 
	 
	 	 	 
	 	By:  	             /s/ Barbara G. McClung
 	 
	 	 	Print Name:  	 Barbara G. McClung 	 
	 	 	Title:  	Secretary
	 
	 	 	 	(Secretary, Assistant Secretary, CFO or Assistant Treasurer)
	 
	 	 	Date:   	10/22/03 	 
	 
	LESSOR:       	Metropolitan Life Insurance Company,

a New York corporation

 	 
	 	By:  	 	 
	 	 	Print Name:  	 	 
	 	 	Title:  	 	 
	 	 	Date:  	 	 
	 

12

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