Document:

EX-10.6

 Exhibit 10.6 

LEASE AGREEMENT 
 THIS
LEASE AGREEMENT (this “Lease”) is made this 21 day of December, 2011, between ARE-MA REGION NO. 38, LLC, a Delaware limited liability company (“Landlord”), and SAGE THERAPEUTICS, INC., a Delaware
corporation (“Tenant”). 
 BASIC LEASE PROVISIONS 

 

			
	Address:	  	215 First Street, Cambridge, MA 02142
		
	Premises:	  	That portion of the second floor of the Building (as defined below) containing approximately 5,900 rentable square feet, as determined by Landlord, as shown on Exhibit A.
		
	Shared Conference Facility:	  	That portion of the Building depicted as the “Shared Conference Facility” on Exhibit C attached hereto, subject to adjustment and relocation by Landlord from time to time.
		
	Project:	  	The real property on which the Building is located, together with all improvements thereon and appurtenances thereto as described on Exhibit D.
		
	Building:	  	That building located on the Project and commonly known and numbered as 215 First Street, Cambridge, Massachusetts.
		
	Base Rent:	  	Months 1 – 12: $37.50 per rsf of the Premises per year
		  	Months 13 – 24: $38.50 per rsf of the Premises per year
		  	Months 25 – 36: $39.50 per rsf of the Premises per year
		  	Months 37 – 48: $40.50 per rsf of the Premises per year
		  	Months 49 – 60: $41.50 per rsf of the Premises per year
		
	Rentable Area of Premises:	  	Approximately 5,900 rentable square feet.
		
	Rentable Area of Project:	  	Approximately 366,719 rentable square feet.
		
	Tenant’s Share:	  	1.61%.
		
	Security Deposit:	  	$38,842
		
	Target Commencement Date:	  	February 15, 2012
		
	Base Year for Operating Expenses:	  	2012
		
	Base Year for Taxes:	  	July 1, 2012 – June 30, 2013
		
	Term:	  	Beginning on the Commencement Date and ending 60 months from the first day of the first full month commencing on or after the Commencement Date.
		
	Permitted Use:	  	Office and related uses consistent with the character of the Project and otherwise in compliance with the provisions of Section 7 hereof.

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	Address for Rent Payment:	  	Landlord’s Notice Address:	  	Tenant’s Notice Address:
	P.O. Box 975383	  	385 East Colorado Boulevard,	  	215 First Street, Suite 430
	Dallas, TX 75397-5383	  	 Suite 299
 Pasadena, CA 91101

Attention: Corporate Secretary
 Facsimile: 626-578-0770
	  	 Cambridge, MA 02142
 Attention: Lease
Administrator

 1. Lease of Premises; Right to Use Common Areas; License to Shared Areas. 

(a) Lease of Premises; Common Areas. Upon and subject to all of the terms and conditions hereof, Landlord hereby leases the Premises to
Tenant and Tenant hereby leases the Premises from Landlord. The portions of the Project that are for the non-exclusive use of tenants of the Project (including but not limited to the restrooms, elevators, stairways, lobbies, corridors, walkways and
Building entrances) are collectively referred to herein as the “Common Areas.” Tenant shall have the non-exclusive right to use the Common Areas of the Project, excluding the (i) shared science facility located at the Project,
which Tenant shall have no right to use, and (ii) Shared Conference Facility to which Tenant’s rights are as set forth in Section 1(b) below. Landlord reserves the right to modify, reconfigure and relocate the Common Areas,
provided that such modifications, reconfigurations or relocations do not affect Tenant’s use of the Premises for the Permitted Use. Notwithstanding the foregoing, no interruption in Building Systems, services or Utilities, from any cause
whatsoever, in connection with any work to effect any such modification, reconfiguration or relocation shall result in eviction or constructive eviction of Tenant, termination of this Lease or the abatement of Rent. Landlord reserves the right to
change the form of ownership of the Project or any part thereof. From and after the Commencement Date through the expiration of the Term, Tenant shall have access to the Building and the Premises 24 hours a day, 7 days a week, except in the case of
emergencies, as the result of Legal Requirements, the performance by Landlord of any installation, maintenance or repairs, or any other temporary interruptions, and otherwise subject to the terms of this Lease. 

(b) Shared Conference Facility. Concurrently with the execution and delivery of this Lease by Tenant, Tenant shall execute and deliver
to Landlord a license agreement in the form attached as Exhibit E attached hereto (the “License Agreement”). Tenant shall have the non-exclusive right to use the Shared Conference Facility pursuant to the terms and conditions
of the License Agreement. Tenant shall have no right to use or access the Shared Conference Facility, except as provided in the License Agreement. 

2. Delivery; Acceptance of Premises; Commencement Date. Landlord shall use reasonable efforts to deliver the Premises to Tenant on or
before the Target Commencement Date, vacant, broom clean and free of all occupants, personal property and debris, with Landlord’s Work Substantially Completed (“Delivery” or “Deliver”). If Landlord fails to so
Deliver the Premises on or before the Target Commencement Date, Landlord shall not be liable to Tenant for any loss or damage resulting therefrom, and this Lease shall not be void or voidable except as provided herein. If Landlord does not Deliver
the Premises within 60 days of the Target Commencement Date for any reason other than Force Majeure delays and Tenant Delays, this Lease may be terminated by Landlord or Tenant by written notice to the other (except that Landlord shall have no right
to terminate this Lease other than in the event of Force Majeure), and if so terminated by either: (a) any Rent paid prior to the date of such termination (except any Rent paid for any time period that Tenant occupied the Premises and conducted
its business therein) the Security Deposit, or any balance thereof (i.e., after deducting therefrom all amounts to which Landlord is entitled under the provisions of this Lease), shall be returned to Tenant, and (b) neither Landlord nor Tenant shall
have any further rights, duties or obligations under this Lease, except with respect to provisions which expressly survive termination of this Lease. As used herein, the terms “Landlord’s Work,” “Tenant Delays”
and “Substantially Completed” shall have the meanings set forth for such terms in the work letter attached to this Lease as Exhibit F (“Work Letter”). If neither Landlord nor Tenant elects to void this Lease
within 5 business days of the lapse of such 60 day period pursuant to this Section 2, such right to void this Lease shall be waived and this Lease shall remain in full force and effect. In addition to Landlord’s Work, Landlord shall
install carpet in the break room area only of the premises located directly above the Premises. Landlord shall endeavor to complete such carpet installation prior to the Commencement Date. 

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 The
“Commencement Date” shall be the earlier of: (i) the date Landlord Delivers the Premises to Tenant; and (ii) the date Landlord could have Delivered the Premises but for Tenant Delays; provided, however, that in no event
shall the Commencement Date occur prior to February 1, 2012. Upon request of Landlord, Tenant shall execute and deliver a written acknowledgment of the Commencement Date and the expiration date of the Term when such are established in the form
of the “Acknowledgement of Commencement Date” attached to this Lease as Exhibit G; provided, however, Tenant’s failure to execute and deliver such acknowledgment shall not affect Landlord’s rights hereunder.
The “Term” of this Lease shall be as defined above in the Basic Lease Provisions and the Extension Term which Tenant may elect pursuant to Section 34 hereof. 

Except as set forth in this Lease: (i) Tenant shall accept the Premises in their condition as of the Commencement Date, subject to all
applicable Legal Requirements (as defined in Section 7 hereof); (ii) Landlord shall have no obligation for any defects in the Premises; and (iii) Tenant’s taking possession of the Premises shall be conclusive evidence that
Tenant accepts the Premises and that the Premises were in good condition at the time possession was taken. The Premises shall be delivered to Tenant without any furniture. 

Subject to the provisions of Section 6 of the Work Letter, Landlord shall permit Tenant access to the Premises commencing on the
date that is 30 days prior to the Commencement Date for Tenant’s installation and set up of its operational wiring and work stations, furniture and other equipment in the Premises (“FF&E Installation”), provided that such
FF&E Installation is coordinated with Landlord, and Tenant complies with the Lease and all other reasonable restrictions and conditions Landlord may impose. All such access shall be during normal business hours. Any access to the Premises by
Tenant before the Commencement Date shall be subject to all of the terms and conditions of this Lease, excluding the obligation to pay Base Rent and Operating Expenses. 

Tenant agrees and acknowledges that neither Landlord nor any agent of Landlord has made any representation or warranty with respect to the
condition of all or any portion of the Premises or the Project, and/or the suitability of the Premises or the Project for the conduct of Tenant’s business, and Tenant waives any implied warranty that the Premises or the Project are suitable for
the Permitted Use. This Lease constitutes the complete agreement of Landlord and Tenant with respect to the subject matter hereof and supersedes any and all prior representations, inducements, promises, agreements, understandings and negotiations
which are not contained herein. 
 3. Base Rent. 

(a) The first month’s Base Rent and Security Deposit shall be due and payable on delivery of an executed copy of this Lease to Landlord.
Tenant shall pay to Landlord in advance, equal monthly installments of Base Rent on or before the first day of each calendar month during the Term hereof, in lawful money of the United States of America, at the office or address of Landlord for
payment of Rent set forth above. If the Commencement Date is other than the first day of a calendar month, the difference between the first full calendar month’s Base Rent paid pursuant to the first sentence of this Section 3(a),
and the prorated Base Rent for the fractional month in which the Commencement Date occurs shall be applied by Landlord to the first full calendar month after the Commencement Date. Base Rent shall be increased during the Base Term as provided for in
the schedule set forth on page 1 of this Lease. Base Rent adjustments for any fractional calendar month shall be prorated. 
 (b) In
addition to Base Rent, Tenant agrees to pay to Landlord as additional rent (“Additional Rent”): (i) Tenant’s Share of “Excess Operating Expenses” (as defined in Section 4), and (ii) any and all other
amounts Tenant assumes or agrees to pay under the provisions of this Lease, including, without limitation, any and all other sums that may become due by reason of any default of Tenant or failure to comply with the agreements, terms, covenants and
conditions of this Lease to be performed by Tenant, after any applicable notice and cure period. Tenant’s obligation to pay Base Rent and Additional Rent hereunder are collectively referred to herein as “Rent”. 

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 4. Operating
Expense Payments. Landlord shall deliver to Tenant a written estimate of Excess Operating Expenses for each calendar year during the Term after the Base Year for Operating Expenses (together, the “Annual Estimate of Excess Operating
Expenses”), which may be revised by Landlord from time to time during such calendar year. During each month of the Term after the Base Year for Operating Expenses, on the same date that Base Rent is due, Tenant shall pay Landlord an amount
equal to 1/12th of Tenant’s Share of Operating Expenses and 1/12th of Tenant’s Share of the Annual Estimate of Excess Operating Expenses as shown on the Annual Estimate of Excess Operating Expenses. Payments for any fractional calendar
month shall be prorated. The term “Excess Operating Expenses” means (i) with respect to Operating Expenses (other than Taxes), Operating Expenses (other than Taxes) for the applicable year in excess of Operating Expenses for
the Base Year for Operating Expenses, and (ii) with respect to Taxes, Taxes for the applicable year in excess of Taxes for the Base Year for Taxes. 

The term “Operating Expenses” means all costs and expenses of any kind or description whatsoever incurred or accrued each
calendar year by Landlord with respect to the Project (including, without duplication, Taxes (as defined below in this Section 4), transportation services (including costs associated with Landlord’s participation in the EZ-Ride
shuttle or a successor shuttle service), capital repairs, replacements and improvements to the Project the purpose of which is to reduce Operating Expenses and/or to comply with Legal Requirements first made effective after the date of this Lease,
which capital repairs, replacements and capital improvements are in each case amortized over the lesser of 7 years and the useful life of such capital items, and the costs of Landlord’s third party property manager (which shall not exceed 3% of
Base Rent) or, if there is no third party property manager, administration rent in the amount of 3.0% of Base Rent), excluding only: 
 (a)
the original construction costs of the Project and renovation prior to the date of the Lease and costs of correcting defects in such original construction or renovation; 

(b) capital expenditures for expansion of the Project or capital improvements that are not for the purpose of reducing Operating Expenses
and/or complying with Legal Requirements first made effective after the date of this Lease; 
 (c) interest, principal payments of Mortgage
(as defined in Section 23) debts of Landlord, financing costs and amortization of funds borrowed by Landlord, whether secured or unsecured and all payments of base rent (but not taxes or operating expenses) under any ground lease or
other underlying lease of all or any portion of the Project; 
 (d) depreciation of the Project (except for those capital improvements, the
cost of which are includable in Operating Expenses as provided above in this Section 4); 
 (e) advertising, legal and space
planning expenses and leasing commissions and other costs and expenses incurred in procuring and leasing space to tenants for the Project, including any leasing office maintained in the Project, free rent and construction allowances for tenants;

 (f) legal and other expenses incurred in the negotiation or enforcement of leases; 

(g) completing, fixturing, improving, renovating, painting, redecorating or other work, which Landlord pays for or performs for other tenants
within their premises, and costs of correcting defects in such work; 
 (h) costs of utilities outside normal business hours sold to tenants
of the Project; 

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 (i) costs to be
reimbursed by other tenants of the Project or Taxes to be paid directly by Tenant or other tenants of the Project, whether or not actually paid; 

(j) salaries, wages, benefits and other compensation paid to officers and employees of Landlord who are not assigned in whole or in part to
the operation, management, maintenance or repair of the Project; 
 (k) general organizational, administrative and overhead costs relating
to maintaining Landlord’s existence, either as a corporation, partnership, or other entity, including general corporate, legal and accounting expenses; 

(l) costs (including attorneys’ fees and costs of settlement, judgments and payments in lieu thereof) incurred in connection with
disputes with tenants, other occupants, or prospective tenants, and costs and expenses, including legal fees, incurred in connection with negotiations or disputes with employees, consultants, management agents, leasing agents, purchasers or
mortgagees of the Building; 
 (m) costs incurred by Landlord due to the violation by Landlord, its employees, agents or contractors or any
tenant of the terms and conditions of any lease of space in the Project or any Legal Requirement (as defined in Section 6); 

(n) penalties, fines or interest incurred as a result of Landlord’s inability or failure to make payment of Taxes and/or to file any tax
or informational returns when due, or from Landlord’s failure to make any payment of Taxes required to be made by Landlord hereunder before delinquency; 

(o) overhead and profit increment paid to Landlord or to subsidiaries or affiliates of Landlord for goods and/or services in or to the Project
to the extent the same exceeds the costs of such goods and/or services rendered by unaffiliated third parties on a competitive basis; 
 (p)
costs of Landlord’s charitable or political contributions, or of fine art maintained at the Project; 
 (q) costs in connection with
services (including electricity), items or other benefits of a type which are not standard for the Project and which are not available to Tenant without specific charges therefor, but which are provided to another tenant or occupant of the Project,
whether or not such other tenant or occupant is specifically charged therefor by Landlord; 
 (r) costs incurred in the sale or refinancing
of the Project; 
 (s) net income taxes of Landlord or the owner of any interest in the Project, franchise, capital stock, gift, estate or
inheritance taxes or any federal, state or local documentary taxes imposed against the Project or any portion thereof or interest therein; 

(t) any expenses otherwise includable within Operating Expenses to the extent actually reimbursed by persons other than tenants of the Project
under leases for space in the Project; and 
 (u) costs incurred in connection with the clean-up, response action or remediation of
Hazardous Materials on the Project or in the Premises that Tenant demonstrates to Landlord’s reasonable satisfaction were present on the Project or in the Premises prior to the date of this Lease, except to the extent Tenant and/or any of the
Tenant Parties have exacerbated or contributed to such contamination. 
 Within 90 days after the end of each calendar year (or such longer
period as may be reasonably required), Landlord shall furnish to Tenant a statement (an “Annual Statement”) showing in reasonable detail: (a) the actual totals of Operating Expenses, Tenant’s Share of Excess Operating Expenses,
in 

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each case for the previous calendar year, and (b) the total of Tenant’s payments in respect of Excess Operating Expenses for such year. If Tenant’s Share of actual Excess Operating
Expenses for such year exceeds Tenant’s payments of Excess Operating Expenses for such year, the excess shall be due and payable by Tenant as Rent within 30 days after delivery of such Annual Statement to Tenant. If Tenant’s payments of
Excess Operating Expenses for such year exceed Tenant’s Share of actual Excess Operating Expenses for such year, Landlord shall pay the excess to Tenant within 30 days after delivery of such Annual Statement, except that after the expiration,
or earlier termination of the Term or if Tenant is delinquent in its obligation to pay Rent, Landlord shall pay the excess to Tenant after deducting all other amounts due Landlord. 

The Annual Statement shall be final and binding upon Tenant unless Tenant, within 90 days after Tenant’s receipt thereof, shall contest
any item therein by giving written notice to Landlord, specifying each item contested and the reason therefor. If, during such 90 day period, Tenant reasonably and in good faith questions or contests the accuracy of Landlord’s statement of
Tenant’s Share of Excess Operating Expenses, Landlord will provide Tenant with access to Landlord’s books and records relating to the operation of the Project and such information as Landlord reasonably determines to be responsive to
Tenant’s questions (the “Expense Information”). If after Tenant’s review of such Expense Information, Landlord and Tenant cannot agree upon the amount of Tenant’s Share of Excess Operating Expenses then Tenant shall
have the right to have an independent public accounting firm selected by Tenant, working pursuant to a fee arrangement other than a contingent fee (at Tenant’s sole cost and expense) and approved by Landlord (which approval shall not be
unreasonably withheld or delayed), audit and/or review the Expense Information for the year in question (the “Independent Review”). The results of any such Independent Review shall be binding on Landlord and Tenant. If the
Independent Review shows that the payments actually made by Tenant with respect to Excess Operating Expenses for the calendar year in question exceeded Tenant’s Share of Excess Operating Expenses for such calendar year, Landlord shall at
Landlord’s option either (i) credit the excess amount to the next succeeding installments of estimated Excess Operating Expenses or (ii) pay the excess to Tenant within 30 days after delivery of such statement, except that after the
expiration or earlier termination of this Lease or if Tenant is delinquent in its obligation to pay Rent, Landlord shall pay the excess to Tenant after deducting all other amounts due Landlord. If the Independent Review shows that Tenant’s
payments with respect to Excess Operating Expenses for such calendar year were less than Tenant’s Share of Excess Operating Expenses for the calendar year, Tenant shall pay the deficiency to Landlord within 30 days after delivery of such
statement. If the Independent Review shows that Tenant has overpaid with respect to Excess Operating Expenses by more than 5% then Landlord shall reimburse Tenant for all costs incurred by Tenant for the Independent Review. 

Excess Operating Expenses for the calendar years in which Tenant’s obligation to share therein begins and ends shall include Excess
Operating Expenses for whole calendar months in such calendar years and any partial calendar months shall be prorated. Notwithstanding anything set forth herein to the contrary, if the Project is not at least 95% occupied on average during any year
of the Term, for such year those expenses included in Tenant’s Share of Excess Operating Expenses that vary with the level of occupancy of the Building shall be computed as though the Project had been 95% occupied on average during such year.

 “Tenant’s Share” shall be the percentage set forth in the Basic Lease Provisions as Tenant’s Share as
reasonably adjusted by Landlord for changes in the physical size of the Premises or the Project occurring thereafter. Landlord may equitably increase Tenant’s Share for any item of expense or cost reimbursable by Tenant that relates to a
repair, replacement, or service that benefits only the Premises or only a portion of the Project that includes the Premises or that varies with occupancy or use. 

Landlord shall pay, as part of Operating Expenses, all taxes, levies, fees, assessments and governmental charges of any kind, existing as of
the Commencement Date or thereafter enacted (collectively referred to as “Taxes”), imposed by any federal, state, regional, municipal, local or other governmental authority or agency, including, without limitation, quasi-public
agencies (collectively, “Governmental Authority”) during the Term, including, without limitation, all Taxes: (i) imposed on or 

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measured by or based, in whole or in part, on rent payable to (or gross receipts received by) Landlord under this Lease and/or from the rental by Landlord of the Project or any portion thereof,
or (ii) based on the square footage, assessed value or other measure or evaluation of any kind of the Premises, or the Project, or (iii) assessed or imposed by or on the operation or maintenance of any portion of the Premises, or the
Project, including parking, or (iv) assessed or imposed by, or at the direction of, or resulting from Legal Requirements, or interpretations thereof, promulgated by, any Governmental Authority, or (v) imposed as a license or other fee,
charge, tax or assessment on Landlord’s business or occupation of leasing space in the Project. Landlord may contest by appropriate legal proceedings the amount, validity, or application of any Taxes or liens securing Taxes. Taxes shall not
include any net income taxes imposed on Landlord except to the extent such net income taxes are in substitution for any Taxes payable hereunder, nor franchise, conveyance, excess profit taxes, transfer taxes, capital stock taxes, estate taxes or
excise taxes. Operating Expenses hereunder shall also include the cost of tax monitoring services provided to Landlord with respect to the Project. Tenant shall pay, prior to delinquency, any and all Taxes levied or assessed against any personal
property or trade fixtures placed by Tenant in the Premises, whether levied or assessed against Landlord or Tenant. If any Taxes on Tenant’s personal property or trade fixtures are levied against Landlord or Landlord’s property, or if the
assessed valuation of the Project is increased by a value attributable to improvements in or alterations to the Premises, whether owned by Landlord or Tenant and whether or not affixed to the real property so as to become a part thereof, higher than
the base valuation on which Landlord from time-to-time allocates Taxes to all tenants in the Project, Landlord shall have the right, but not the obligation, to pay such Taxes. Landlord’s determination of any excess assessed valuation shall be
binding and conclusive, absent manifest error. The amount of any such payment by Landlord shall constitute Additional Rent due from Tenant to Landlord immediately upon demand. If Landlord shall receive any abatement or refund of Taxes that does not
derive from any vacancy in the Building or rent losses and such abatement or refund is for a time period for which Tenant has made payments during the Term, then out of any balance remaining after deducting Landlord’s expenses incurred in
obtaining such refund or abatement, Landlord shall, at Landlord’s option, either (i) credit the excess amount determined by Landlord to be attributable to the Premises to the next succeeding installments of estimated Taxes or (ii) pay
the excess amount determined by Landlord to be attributable to the Premises to Tenant within 30 days after delivery of the Annual Statement, except that after the expiration or earlier termination of this Lease or if Tenant is delinquent in its
obligation to pay Rent, Landlord shall pay such excess amount determined by Landlord to be attributable to the Premises to Tenant after deducting all other amounts due Landlord. Nothing contained in this Lease shall obligate Landlord to seek a
refund or abatement of Taxes. 
 5. Security Deposit. Tenant shall deposit with Landlord, upon delivery of an executed copy of this
Lease to Landlord, a security deposit (the “Security Deposit”) for the performance of all of Tenant’s obligations hereunder in the amount set forth in the Basic Lease Provisions, which Security Deposit shall be in the form of
an unconditional and irrevocable letter of credit (the “Letter of Credit”): (i) in form and substance reasonably satisfactory to Landlord, (ii) naming Landlord as beneficiary, (iii) expressly allowing Landlord to draw upon it
at any time from time to time by delivering to the issuer notice that Landlord is entitled to draw thereunder, (iv) issued by a FDIC-insured financial institution satisfactory to Landlord, and (v) redeemable by presentation of a sight draft (which
may be presented by delivery by overnight courier) at the financial institution’s offices in the United States. With respect to any Letter of Credit given as a Security Deposit or Additional Security Deposit (as defined below) hereunder, if
Tenant does not provide Landlord with a substitute Letter of Credit complying with all of the requirements hereof at least 10 days before the stated expiration date of any then current Letter of Credit, Landlord shall have the right to draw the full
amount of the current Letter of Credit and hold the funds drawn in cash without obligation for interest thereon as the Security Deposit and, if applicable, the Additional Security Deposit. The Security Deposit and Additional Security Deposit, if
any, shall be held by Landlord as security for the performance of Tenant’s obligations under this Lease. The Security Deposit and, if any, Additional Security Deposit do not constitute an advance rental deposit or a measure of Landlord’s
damages in case of Tenant’s default. Upon each occurrence of a Default (as defined in Section 16), Landlord may use all or any part of the Security Deposit and, if any, the Additional Security Deposit to pay delinquent payments due under
this Lease, and the cost of any damage, injury, expense or liability caused by such Default, without prejudice to any other remedy provided herein or provided by law 

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Tenant hereby waives the provisions of any law, now or hereafter in force, which provide that Landlord may claim from a security deposit only those sums reasonably necessary to remedy defaults in
the payment of Rent, to repair damage caused by Tenant or to clean the Premises, it being agreed that Landlord may, in addition, claim those sums reasonably necessary to compensate Landlord for any other loss or damage, foreseeable or unforeseeable,
caused by the act or omission of Tenant or any officer, employee, agent or invitee of Tenant. Upon any such use of all or any portion of the Security Deposit and/or Additional Security Deposit, Tenant shall, within 5 days after demand from Landlord,
restore the Security Deposit to its original amount. If Tenant shall fully perform every provision of this Lease to be performed by Tenant, the Security Deposit, or any balance thereof (i.e., after deducting therefrom all amounts to which Landlord
is entitled under the provisions of this Lease), shall be returned to Tenant (or, at Landlord’s option, to the last assignee of Tenant’s interest hereunder) within 90 days after the expiration or earlier termination of this Lease. 

6. Use. The Premises shall be used solely for the Permitted Use set forth in the Basic Lease Provisions, in compliance with all laws,
orders, judgments, ordinances, regulations, codes, directives, permits, licenses, covenants and restrictions now or hereafter applicable to the Premises, and the use and occupancy thereof (collectively, “Legal Requirements”). Tenant
will use the Premises in a careful, safe and proper manner and will not commit waste, overload the floor or structure of the Premises, subject the Premises to use that would damage the Premises or obstruct or interfere with the rights of Landlord or
other tenants or occupants of the Project, including conducting or giving notice of any auction, liquidation, or going out of business sale on the Premises, or using or allowing the Premises to be used for any unlawful purpose. 

7. Holding Over. If Tenant remains in possession of the Premises after the expiration or earlier termination of the Term without the
express written consent of Landlord, (A) Tenant shall become a tenant at sufferance upon the terms of this Lease except that the monthly rental shall be equal to 150% of the Rent in effect during the last 30 days of the Term, and
(B) Tenant shall be responsible for all damages suffered by Landlord resulting from or occasioned by Tenant’s holding over, including consequential damages. Acceptance by Landlord of Rent after the expiration of the Term or earlier
termination of this Lease shall not result in a renewal or reinstatement of this Lease. 
 8. Parking. Subject to all matters of
record, Force Majeure, a casualty or Taking (as defined in Section 15 below) and the exercise by Landlord of its rights hereunder, Landlord shall make available to Tenant at then-current market rates from time to time a license for 6
parking spaces in the surface parking lots at the Project or at the “Brown Lot” at 100 Binney Street, Cambridge, Massachusetts, all of such parking spaces to be on a non-reserved basis; provided, however, that Tenant shall be required to
pay for the number of parking spaces that Tenant from time to time elects to license pursuant to this Section 8 (not to exceed 6 parking spaces). As of the Commencement Date, the market parking rate for the parking spaces in such surface
lots is $220 per parking space per month. Tenant shall notify Landlord prior to the Commencement Date as to how many parking spaces (not to exceed 6) that Tenant will initially license hereunder and Tenant shall give Landlord 30 days’ notice if
it wishes to license additional spaces during the Term, up to 6 spaces in the aggregate hereunder. Landlord shall not be responsible for enforcing Tenant’s parking rights against any third parties, including without limitation other tenants of
the Project. Landlord shall have the right, exercisable by notice to Tenant given at any time during the Term, to relocate all or a portion of the parking spaces made available to Tenant hereunder to another location within a 7-minute walk of the
Building. 
 9. Utilities, Services. 

(a) The hours of operation of the Project are 8:00 a.m. to 6:00 p.m., Monday through Friday and 8:00 a.m. to 1:00 p.m. on Saturday, legal
holidays excepted. Landlord shall provide, subject to the terms of this Section 9, water, electricity, heat and air conditioning (“HVAC”)(during such hours of operation), light, power, passenger elevator service,
telephone (to the central demarcation room only), sewer, and other utilities (including gas and fire sprinklers to the extent the Project is plumbed for such services) to the Premises, the Common Areas and the Shared Conference Facility, and, for
the Premises, 

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Common Areas and Shared Conference Facility, refuse and trash collection and janitorial services (collectively, “Utilities”). Upon request, Landlord shall make available at
Tenant’s sole cost and expense after hours HVAC. The minimum use of after hours HVAC and the cost thereof shall be determined by Landlord and may thereafter be amended by Landlord as the same may change from time to time upon reasonable advance
notice to Tenant. Landlord shall pay, as part of Operating Expenses or subject to Tenant’s reimbursement obligation, for all Utilities used on the Premises, all maintenance charges for Utilities, and any storm sewer charges or other similar
charges for Utilities imposed by any Governmental Authority or Utility provider, and any taxes, penalties, surcharges or similar charges thereon. Electricity serving the Premises will be separately submetered, at Landlord’s expense, and
electricity to the Premises shall be charged directly to Tenant by Landlord. Landlord may cause, at Landlord’s expense, any other Utilities to be separately metered or charged directly to Tenant by the provider. Tenant shall pay directly to the
Utility provider, prior to delinquency, any separately metered Utilities and services which may be furnished to Tenant or the Premises during the Term. Tenant shall pay, as part of Operating Expenses, its share of all charges for jointly metered
Utilities based upon consumption, as reasonably determined by Landlord. No interruption or failure of Utilities, from any cause whatsoever, shall result in eviction or constructive eviction of Tenant, termination of this Lease or the abatement of
Rent. Tenant agrees to limit use of water and sewer with respect to Common Areas to normal restroom use. 
 (b) Landlord shall, as an
Operating Expense, provide janitorial services and trash collection for the Premises, and a dumpster and/or compactor at the loading dock for use by Tenant in common with others entitled thereto for the disposal of non-hazardous and non-controlled
substances and material. 
 (c) Tenant may use the freight elevator and loading dock in common with others entitled thereto at no additional
charge. The regular hours of operation of the freight elevator and loading dock are 24 hours per day, 7 days per week, subject to downtime for maintenance and repairs. Tenant shall provide Landlord with advance written notice prior to Tenant’s
use of the freight elevator and/or loading dock outside of the hours of operation of the Project set forth in Section 9(a) above. 

10. Alterations; Tenant’s Property. Any alterations, additions, or improvements made to the Premises by or on behalf of Tenant,
including additional locks or bolts of any kind or nature upon any doors or windows in the Premises, but excluding installation, removal or realignment of furniture systems (other than removal of furniture systems owned or paid for by Landlord) not
involving any modifications to the structure or connections (other then by ordinary plugs or jacks) to Building Systems (as defined in Section 11(a) below) (“Alterations”) shall be subject to Landlord’s prior
written consent, which may be given or withheld in Landlord’s sole discretion if any such Alteration affects the structure or Building Systems, but which shall otherwise not be unreasonably withheld or delayed. If Landlord approves any
Alterations, Landlord may impose such conditions on Tenant in connection with the commencement, performance and completion of such Alterations as Landlord may deem appropriate in Landlord’s reasonable discretion. Tenant agrees to take such
steps as may be required, or as otherwise directed by Landlord, with respect to contractors and subcontractors performing any Alterations to ensure that no labor disruption, strikes, pickets, protests or other similar labor actions occur on or about
the Premises in connection with the performance of work on any Alterations. Any request for approval of Alterations shall be in writing, delivered not less than 15 business days in advance of any proposed construction, and accompanied by plans,
specifications, bid proposals, work contracts and such other information concerning the nature and cost of the Alterations as may be reasonably requested by Landlord, including the identities and mailing addresses of all persons performing work or
supplying materials. Landlord’s right to review plans and specifications and to monitor construction shall be solely for its own benefit, and Landlord shall have no duty to ensure that such plans and specifications or construction comply with
applicable Legal Requirements. Tenant shall cause, at its sole cost and expense, all Alterations to comply with insurance requirements and with Legal Requirements and shall implement at its sole cost and expense any alteration or modification
required by Legal Requirements as a result of any Alterations. Tenant shall pay to Landlord, as Additional Rent, within 10 days after demand Landlord’s out-of-pocket expenses for plan review, coordination, scheduling and supervision in
connection with any Alterations. 

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Before Tenant begins any Alteration, Landlord may post on and about the Premises notices of non-responsibility pursuant to applicable law. Tenant shall reimburse Landlord for, and indemnify and
hold Landlord harmless from, any expense incurred by Landlord by reason of faulty work done by Tenant or its contractors, delays caused by such work, or inadequate cleanup. 

Tenant shall furnish security or make other arrangements satisfactory to Landlord to assure payment for the completion of all Alterations work
free and clear of liens, and shall provide (and cause each contractor or subcontractor to provide) certificates of insurance for workers’ compensation and other coverage in amounts and from an insurance company satisfactory to Landlord
protecting Landlord against liability for personal injury or property damage during construction. Upon completion of any Alterations, Tenant shall deliver to Landlord: (i) sworn statements setting forth the names of all contractors and
subcontractors who did the work and final lien waivers from all such contractors and subcontractors; and (ii) “as built” plans for any such Alteration. 

Other than (i) the items, if any, listed on Exhibit H attached hereto, (ii) any items agreed by Landlord in writing to be
included on Exhibit H in the future, and (iii) any trade fixtures, machinery, equipment and other personal property not installed by Landlord which may be removed without material damage to the Premises, which damage shall be repaired
(including capping or terminating utility hook-ups behind walls) by Tenant during the Term (collectively, “Tenant’s Property”), all property of any kind paid for or installed by Landlord or its contractor as part of the Tenant
Improvements, Alterations, real property fixtures, built-in machinery and equipment, built-in cabinets and other similar additions and improvements built into the Premises so as to become an integral part of the Premises, such as electrical and
mechanical equipment and systems, and any power generator and transfer switch (collectively, “Installations”) shall be and shall remain the property of Landlord during the Term and following the expiration or earlier termination of
the Term, shall not be removed by Tenant at any time during the Term and shall remain upon and be surrendered with the Premises as a part thereof in accordance with Section 24 following the expiration or earlier termination of this
Lease; provided, however, that Landlord shall, at the time its approval of such Installation is requested notify Tenant in writing if Landlord elects to cause Tenant to remove such Installation upon the expiration or earlier
termination of this Lease. If Landlord so elects, Tenant shall remove such Installation upon the expiration or earlier termination of this Lease and restore any damage caused by or occasioned as a result of such removal, including, when removing any
of Tenant’s Property which was plumbed, wired or otherwise connected to any of the Building’s plumbing, electrical or other Building Systems, capping off all such connections behind the walls of the Premises and repairing any holes. During
any such restoration period, Tenant shall pay Rent to Landlord as provided herein as if said space were otherwise occupied by Tenant. 
 11.
Repairs. 
 (a) Landlord’s Repairs. Landlord, as an Operating Expense, shall maintain all of the structural, exterior,
parking and other Common Areas of the Project, including HVAC, plumbing, fire sprinklers, elevators and all other building systems serving the Premises and other portions of the Project (“Building Systems”), in good repair,
reasonable wear and tear and uninsured losses and damages caused by Tenant, or by any of Tenant’s agents, servants, employees, invitees and contractors (individually, a “Tenant Party” and collectively, “Tenant
Parties”) excluded. Subject to the provisions of the last paragraph of Section 14, Landlord shall repair losses and damages caused by Tenant or any Tenant Party at Tenant’s sole cost and expense. Such maintenance and
repairs by Landlord under this Section shall include Landlord’s making such replacements as Landlord may deem necessary in its sole discretion. Landlord reserves the right to stop building system services when necessary by reason of accident or
emergency, or for repairs, alterations or improvements. Landlord shall have no responsibility or liability for failure to supply building system services during any such period of interruption; provided, however, that Landlord shall
give Tenant 24 hours advance notice of any planned stoppage of building system services for routine maintenance, repairs, alterations or improvements. Landlord shall not be liable for any failure to make any repairs or to perform any maintenance
unless such failure shall persist for an unreasonable time after Tenant’s written notice of the need for such repairs or maintenance. Tenant waives its rights under any state or local law to terminate this Lease or to make such repairs at

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Landlord’s expense and agrees that the parties’ respective rights with respect to such matters shall be solely as set forth herein. Repairs required as the result of fire, earthquake,
flood, vandalism, war, or similar cause of damage or destruction shall be controlled by Section 15. 
 (b) Tenant’s
Repairs. Subject to Section 11(a) and Section 15 hereof, Tenant, at its expense, shall repair, replace and maintain in good condition, reasonable wear and tear and damage covered by Section 15 excepted, all
portions of the Premises, including, without limitation, entries, doors, ceilings, interior windows (excluding exterior glass), interior walls, and the interior side of demising walls. Such repair and replacement may include capital expenditures and
repairs whose benefit may extend beyond the Term. Should Tenant fail to make any such repair or replacement or fail to maintain the Premises, Landlord shall give Tenant notice of such failure. If Tenant fails to commence cure of such failure within
10 days of Landlord’s notice, and thereafter diligently prosecute such cure to completion, Landlord may perform such work and shall be reimbursed by Tenant within 10 days after demand therefor; provided, however, that if such failure by Tenant
creates or could create an emergency, Landlord may immediately commence cure of such failure and shall thereafter be entitled to recover the costs of such cure from Tenant. Subject to Section 14 and Section 15, Tenant shall
bear the full uninsured cost of any repair or replacement to any part of the Project that results from damage caused by Tenant or any Tenant Party and any repair that benefits only the Premises. 

12. Liens. Tenant shall discharge, by bond or otherwise, any liens filed against the Premises or against the Project arising out of
work performed or claimed to have been performed, materials furnished or claimed to have been or obligations incurred or claimed to have been incurred by Tenant within 10 days after Tenant receives notice of the filing thereof, at Tenant’s sole
cost. 
 13. Indemnification. Tenant hereby indemnifies and agrees to defend, save and hold Landlord harmless from and against any
and all claims for injury or death to persons or damage to property (i) occurring within the Premises and arising directly or indirectly out of use or occupancy of the Premises, unless caused solely by the willful misconduct or negligence of
Landlord, (ii) occurring outside of the Premises (including without limitation in the Shared Conference Facility) and arising directly or indirectly out of an act or omission of Tenant, or (iii) arising directly or indirectly out of or a
breach or default by Tenant in the performance of any of its obligations hereunder or under the License Agreement. Landlord shall not be liable to Tenant for, and Tenant assumes all risk of damage to, personal property (including, without
limitation, loss of records kept within the Premises or any part of the Project). Tenant further waives any and all claims for injury to Tenant’s business or loss of income relating to any such damage or destruction of personal property
(including, without limitation, any loss of records). Landlord shall not be liable for any damages arising from any act, omission or neglect of any tenant in the Project or of any other third party. 

14. Insurance. Landlord shall, as an Operating Expense, maintain such insurance covering the Project as Landlord shall reasonably
determine. Tenant, at its sole cost and expense, shall maintain during the Term: all risk property insurance with business interruption and extra expense coverage, covering the full replacement cost of all property and improvements installed or
placed in the Premises by Tenant at Tenant’s expense; workers’ compensation insurance with no less than the minimum limits required by law; employer’s liability insurance with such limits as required by law; and commercial general
liability insurance, with a minimum limit of not less than $2,000,000 per occurrence for bodily injury and property damage with respect to the Premises and Shared Conference Facility. The commercial general liability insurance policy shall name
Landlord, its officers, directors, employees, managers, members and agents (individually, a “Landlord Party” and collectively, “Landlord Parties”) and Alexandria Real Estate Equities, Inc., as additional insureds;
insure on an occurrence and not a claims-made basis; be issued by insurance companies which have a rating of not less than policyholder rating of A- and financial category rating of at least Class VIII in “Best’s Insurance Guide”;
shall not be cancelable for nonpayment of premium unless 10 days prior written notice shall have been given to Landlord from the insurer; contain a hostile fire endorsement and a contractual liability endorsement; and provide primary coverage to
Landlord (any policy issued to Landlord providing duplicate or similar coverage shall be deemed excess over Tenant’s policies). Certificates of insurance showing the limits of coverage required hereunder and

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showing Landlord as an additional insured, along with reasonable evidence of the payment of premiums for the applicable period, shall be delivered to Landlord by Tenant upon commencement of the
Term and upon each renewal of said insurance. Tenant’s policy may be a “blanket policy” with an aggregate per location endorsement which specifically provides that the amount of insurance shall not be prejudiced by other losses
covered by the policy. Tenant shall, at least 5 days prior to the expiration of such policies, furnish Landlord with renewal certificates. 

In each instance where insurance is to name Landlord as an additional insured, Tenant shall upon written request of Landlord also designate
and furnish certificates so evidencing Landlord as additional insured to: (i) any lender of Landlord holding a security interest in the Project or any portion thereof and any servicer in connection therewith, (ii) the landlord under any
lease wherein Landlord is tenant of the real property on which the Project is located, if the interest of Landlord is or shall become that of a tenant under a ground or other underlying lease rather than that of a fee owner, and/or (iii) any
management company retained by Landlord to manage the Project. 
 The property insurance obtained by Landlord and Tenant shall include a
waiver of subrogation by the insurers and all rights based upon an assignment from its insured, against Landlord or Tenant, and their respective officers, directors, employees, managers, members and agents (“Related Parties”), in
connection with any loss or damage thereby insured against. Neither party nor its respective Related Parties shall be liable to the other for loss or damage caused by any risk insured against under property insurance required to be maintained
hereunder, and each party waives any claims against the other party, and its respective Related Parties, for such loss or damage. The failure of a party to insure its property shall not void this waiver. Landlord and its respective Related Parties
shall not be liable for, and Tenant hereby waives all claims against such parties for, business interruption and losses occasioned thereby sustained by Tenant or any person claiming through Tenant resulting from any accident or occurrence in or upon
the Premises or the Project from any cause whatsoever. If the foregoing waivers shall contravene any law with respect to exculpatory agreements, the liability of Landlord or Tenant shall be deemed not released but shall be secondary to the
other’s insurer. 
 15. Condemnation and Casualty. If at any time during the Term the Premises, Common Areas or Project is in
whole or in part (i) materially damaged or destroyed by a fire or other casualty, or (ii) taken for any public or quasi-public use under governmental law, ordinance, or regulation, or by right of eminent domain, or by private purchase in
lieu thereof (a “Taking”), then this Lease shall, at the written election of Landlord delivered to Tenant within sixty (60) days following such casualty or taking, terminate as of the date of such damage, destruction or Taking.
If at any time during the Term the Premises or Common Areas are in whole or in part (i) materially damaged or destroyed by a fire or other casualty, or (ii) subject to a Taking, then this Lease shall, at the written election of Tenant delivered
to Landlord within sixty (60) days following such casualty or taking, terminate as of the date of such damage, destruction or Taking. Unless either Landlord or Tenant so elects to terminate this Lease, Landlord shall, subject to receipt of
sufficient insurance proceeds (with any deductible to be treated as a current Operating Expense), promptly restore the Premises and Common Areas (excluding the improvements installed by Tenant or by Landlord and paid for by Tenant), subject to
delays arising from the collection of insurance proceeds, from Force Majeure events. 
 If neither Tenant nor Landlord elect to terminate
this Lease pursuant to the immediately preceding paragraph, Rent shall be abated from the date of discovery of such damage or destruction until the Premises or Common Areas are repaired and restored, in the proportion which the area of the Premises,
if any, which is not usable by Tenant bears to the total area of the Premises, unless Landlord provides Tenant with other space during the period of repair that is suitable for the temporary conduct of Tenant’s business. Such abatement shall be
the sole remedy of Tenant, and except as provided in this Section 15, Tenant waives any right to terminate the Lease by reason of damage or casualty loss, provided that, if Landlord shall fail to restore the Premises or Common
Areas within 12 months of the end of the 60-day period referred to in the first and second sentences of the immediately preceding paragraph), Tenant shall have a further right to terminate this Lease by written notice to Landlord delivered within 60
days after the expiration of such 12-month period, provided further, that if Landlord completes such restoration within 30 days after receipt of Tenant’s termination notice, such termination notice shall be void and this Lease shall continue in
full force and effect. 

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 The provisions of
this Lease, including this Section 15, constitute an express agreement between Landlord and Tenant with respect to any and all damage to, or destruction of, all or any part of the Premises, or any other portion of the Project, and any
statute or regulation which is now or may hereafter be in effect shall have no application to this Lease or any damage or destruction to all or any part of the Premises or any other portion of the Project, the parties hereto expressly agreeing that
this Section 15 sets forth their entire understanding and agreement with respect to such matters. Upon any fire or other casualty or Taking, Landlord shall be entitled to receive the entire proceeds of the insurance maintained by
Landlord and the entire price or award from any such Taking without, in either case, any payment to Tenant, and Tenant hereby assigns to Landlord Tenant’s interest, if any, in such proceeds or award, except that Tenant shall have the right, to
the extent that same shall not diminish Landlord’s award, to make a separate claim against the condemning authority (but not Landlord) for such compensation as may be separately awarded or recoverable by Tenant for moving expenses and damage to
Tenant’s trade fixtures, if a separate award for such items is made to Tenant. 
 16. Events of Default. Each of the following
events shall be a default (“Default”) by Tenant under this Lease: 
 (a) Payment Defaults. Tenant shall fail to pay
any installment of Rent or any other payment hereunder when due; provided, however, that Landlord will give Tenant notice and an opportunity to cure any failure to pay Rent within 3 business days of any such notice not more than once
in any 12 month period and Tenant agrees that such notice shall be in lieu of and not in addition to, or shall be deemed to be, any notice required by law; provided, further, however, that no such notice or opportunity to cure
shall be required for any failure by Tenant to pay the first month’s Base Rent and deliver the Security Deposit to Landlord at such time as required pursuant to Section 3(a) above. 

(b) Insurance. Any insurance required to be maintained by Tenant pursuant to this Lease shall be canceled or terminated or shall expire
or shall be reduced or materially changed, or Landlord shall receive a notice of nonrenewal of any such insurance and Tenant shall fail to obtain replacement insurance at least 10 days before the expiration of the current coverage. 

(c) Improper Transfer. Tenant shall assign, sublease or otherwise transfer or attempt to transfer all or any portion of Tenant’s
interest in this Lease or the Premises except as may be expressly permitted herein, or Tenant’s interest in this Lease shall be attached, executed upon, or otherwise judicially seized and such action is not released within 90 days of the
action. 
 (d) Liens. Tenant shall fail to discharge or otherwise obtain the release of any lien upon the Premises in violation of
this Lease within 10 days after any such lien is filed against the Premises. 
 (e) Insolvency Events. Tenant or any guarantor or
surety of Tenant’s obligations hereunder shall: (A) make a general assignment for the benefit of creditors; (B) commence any case, proceeding or other action seeking to have an order for relief entered on its behalf as a debtor or to
adjudicate it a bankrupt or insolvent, or seeking reorganization, arrangement, adjustment, liquidation, dissolution or composition of it or its debts or seeking appointment of a receiver, trustee, custodian or other similar official for it or for
all or of any substantial part of its property (collectively a “Proceeding for Relief”); (C) become the subject of any Proceeding for Relief which is not dismissed within 90 days of its filing or entry; or (D) die or suffer a
legal disability (if Tenant, guarantor, or surety is an individual) or be dissolved or otherwise fail to maintain its legal existence (if Tenant, guarantor or surety is a corporation, partnership or other entity). 

(f) Estoppel Certificate or Subordination Agreement. Tenant fails to execute any document required from Tenant under Sections 19
or 23 within 5 business days after a second notice requesting such document. 

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 (g) Default under
License. Tenant shall be in default or breach of any of its obligations under the License beyond any cure period as may be expressly set forth in the License. 

(h) Other Defaults. Tenant shall fail to comply with any provision of this Lease other than those specifically referred to in this
Section 16, and, except as otherwise expressly provided herein, such failure shall continue for a period of 30 days after written notice thereof from Landlord to Tenant, provided that if the nature of such default is such that it cannot
be cured by the payment of money and reasonably requires more than 30 days to cure, then Tenant shall not be deemed to be in Default if Tenant commences such cure within 30 days of the aforesaid notice from Landlord and thereafter diligently
prosecutes such cure to completion within 90 days of the aforesaid notice from Landlord. Any notice given under this Section 16(h) shall: (i) specify the alleged default, (ii) demand that Tenant cure such default, (iii) be
in lieu of, and not in addition to, or shall be deemed to be, any notice required under any provision of applicable law, and (iv) not be deemed a forfeiture or a termination of this Lease unless Landlord elects otherwise in such notice. 

17. Landlord’s Remedies. 

(a) Payment By Landlord; Interest. Upon a Default by Tenant hereunder, Landlord may, without waiving or releasing any obligation of
Tenant hereunder, make such payment or perform such act that is the subject of the Default. All reasonable sums so paid or incurred by Landlord, together with interest thereon, from the date such sums were paid or incurred, at the annual rate equal
to 12% per annum or the highest rate permitted by law (the “Default Rate”), whichever is less, shall be payable to Landlord on demand as Additional Rent. Nothing herein shall be construed to create or impose a duty on Landlord
to mitigate any damages resulting from Tenant’s Default hereunder. 
 (b) Late Payment Rent. Late payment by Tenant to Landlord
of Rent and other sums due will cause Landlord to incur costs not contemplated by this Lease, the exact amount of which will be extremely difficult and impracticable to ascertain. Such costs include, but are not limited to, processing and accounting
charges and late charges which may be imposed on Landlord under any Mortgage covering the Premises. Therefore, if any installment of Rent due from Tenant is not received by Landlord within 5 days after the date such payment is due, Tenant shall pay
to Landlord an additional sum equal to 6% of the overdue Rent as a late charge. The parties agree that this late charge represents a fair and reasonable estimate of the costs Landlord will incur by reason of late payment by Tenant. In addition to
the late charge, Rent not paid when due shall bear interest at the Default Rate from the 5th day after the date due until paid. 
 (c)
Other Remedies. Upon and during the continuance of a Default, Landlord, at its option, without further notice or demand to Tenant, shall have in addition to all other rights and remedies provided in this Lease, at law or in equity, the option
to pursue any one or more of the following remedies, each and all of which shall be cumulative and nonexclusive, without any notice or demand whatsoever. No cure in whole or in part of such Default by Tenant after Landlord has taken any action
beyond giving Tenant notice of such Default to pursue any remedy provided for herein (including retaining counsel to file an action or otherwise pursue any remedies) shall in any way affect Landlord’s right to pursue such remedy or any other
remedy provided Landlord herein or under law or in equity, unless Landlord, in its sole discretion, elects to waive such Default. 
 This
Lease and the Term and estate hereby granted are subject to the limitation that whenever a Default shall have happened and be continuing, Landlord shall have the right, at its election, then or thereafter while any such Default shall continue and
notwithstanding the fact that Landlord may have some other remedy hereunder or at law or in equity, to give Tenant written notice of Landlord’s intention to terminate this Lease on a date specified in such notice, which date shall be not less
than 5 days after the giving of such notice, and upon the date so specified, this Lease and the estate hereby granted shall expire and terminate with the same force and effect as if the date specified in such notice were the date hereinbefore fixed
for the expiration of this Lease, and all rights of Tenant hereunder shall expire and terminate, and Tenant shall be liable as hereinafter in this Section 17(c) provided. If any such notice is

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given, Landlord shall have, on such date so specified, the right of re-entry and possession of the Premises and the right to remove all persons and property therefrom and to store such property
in a warehouse or elsewhere at the risk and expense, and for the account, of Tenant. Should Landlord elect to re-enter as herein provided or should Landlord take possession pursuant to legal proceedings or pursuant to any notice provided for by law,
Landlord may from time to time re-let the Premises or any part thereof for such term or terms and at such rental or rentals and upon such terms and conditions as Landlord may deem advisable, with the right to make commercially reasonable alterations
in and repairs to the Premises. 
 (i) In the event of any termination of this Lease as in this Section 17
provided or as required or permitted by law or in equity, Tenant shall forthwith quit and surrender the Premises to Landlord, and Landlord may, without further notice, enter upon, re-enter, possess and repossess the same by summary proceedings,
ejectment or otherwise, and again have, repossess and enjoy the same as if this Lease had not been made, and in any such event Tenant and no person claiming through or under Tenant by virtue of any law or an order of any court shall be entitled to
possession or to remain in possession of the Premises. Landlord, at its option, notwithstanding any other provision of this Lease, shall be entitled to recover from Tenant, as and for liquidated damages, the sum of; 

(A) all Base Rent, Additional Rent and other amounts payable by Tenant hereunder then due or accrued and unpaid: and 

(B) the amount equal to the aggregate of all unpaid Base Rent and Additional Rent which would have been payable if this Lease
had not been terminated prior to the end of the Term then in effect, discounted to its then present value in accordance with accepted financial practice using a rate of 5% per annum, for loss of the bargain; and 

(C) all other damages and expenses (including attorneys’ fees and expenses), if any, which Landlord shall have sustained
by reason of the breach of any provision of this Lease; less 
 (D) the net proceeds of any re-letting actually received by
Landlord and (ii) the amount of damages which Tenant proves could have been avoided had Landlord taken reasonable steps to mitigate its damages. 

(ii) Nothing herein contained shall limit or prejudice the right of Landlord, in any bankruptcy or insolvency proceeding, to
prove for and obtain as liquidated damages by reason of such termination an amount equal to the maximum allowed by any bankruptcy or insolvency proceedings, or to prove for and obtain as liquidated damages by reason of such termination, an amount
equal to the maximum allowed by any statute or rule of law whether such amount shall be greater or less than the excess referred to above. 

(iii) Nothing in this Section 17 shall be deemed to affect the right of either party to indemnifications pursuant
to this Lease. 
 (iv) If Landlord terminates this Lease upon the occurrence of a Default, Tenant will quit and surrender the
Premises to Landlord or its agents, and Landlord may, without further notice, enter upon, re-enter and repossess the Premises by summary proceedings, ejectment or otherwise. The words “enter”, “re-enter”, and “re-entry”
are not restricted to their technical legal meanings. 
 (v) If either party shall be in default in the observance or
performance of any provision of this Lease, and an action shall be brought for the enforcement thereof in which it shall be determined that such party was in default, the party in default shall pay to the other all fees, costs and other expenses
which may become payable as a result thereof or in connection therewith, including attorneys’ fees and expenses. 

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 (vi)
If Tenant shall default in the keeping, observance or performance of any covenant, agreement, term, provision or condition herein contained, Landlord, without thereby waiving such default, may perform the same for the account and at the expense of
Tenant (a) immediately or at any time thereafter and without notice in the case of emergency or in case such default will result in a violation of any legal or insurance requirements, or in the imposition of any lien against all or any portion
of the Premises, and (b) in any other case if such default continues after any applicable cure period provided in Section 16. All reasonable costs and expenses incurred by Landlord in connection with any such performance by it for
the account of Tenant and also all reasonable costs and expenses, including attorneys’ fees and disbursements incurred by Landlord in any action or proceeding (including any summary dispossess proceeding) brought by Landlord to enforce any
obligation of Tenant under this Lease and/or right of Landlord in or to the Premises, shall be paid by Tenant to Landlord within 10 days after demand. 

(vii) Independent of the exercise of any other remedy of Landlord hereunder or under applicable law, Landlord may conduct an
environmental test of the Premises subject to and as more particularly described in Section 26(c), at Tenant’s expense. 

(viii) In the event that Tenant is in breach or Default under this Lease, whether or not Landlord exercises its right to
terminate or any other remedy, Tenant shall reimburse Landlord upon demand for any costs and expenses that Landlord may incur in connection with any such breach or Default, as provided in this Section 17(c). Such costs shall include
reasonable legal fees and costs incurred for the negotiation of a settlement, enforcement of rights or otherwise. Tenant shall also indemnify Landlord against and hold Landlord harmless from all costs, expenses, demands and liability, including
without limitation, reasonable legal fees and costs Landlord shall incur if Landlord shall become or be made a party to any claim or action instituted by Tenant against any third party, or by or against any person holding any interest under or using
the Premises by license of or agreement with Tenant. 
 (d) Except as otherwise provided in this Section 17, no right or remedy
herein conferred upon or reserved to Landlord is intended to be exclusive of any other right or remedy, and every right and remedy shall be cumulative and in addition to any other legal or equitable right or remedy given hereunder, or now or
hereafter existing. No waiver of any provision of this Lease shall be deemed to have been made unless expressly so made in writing. Landlord shall be entitled, to the extent permitted by law, to seek injunctive relief in case of the violation, or
attempted or threatened violation, of any provision of this Lease, or to seek a decree compelling observance or performance of any provision of this Lease, or to seek any other legal or equitable remedy. 

18. Assignment and Subletting. 

(a) General Prohibition. Without Landlord’s prior written consent subject to and on the conditions described in this
Section 18, Tenant shall not, directly or indirectly, voluntarily or by operation of law, assign this Lease or sublease the Premises or any part thereof or mortgage, pledge, or hypothecate its leasehold interest or grant any concession
or license within the Premises, and any attempt to do any of the foregoing shall be void and of no effect. Except as expressly permitted in this Section 18(a), if Tenant is a corporation, partnership or limited liability company, the
shares or other ownership interests thereof which are not actively traded upon a stock exchange or in the over-the-counter market, a transfer or series of transfers whereby 50% or more of the issued and outstanding shares or other ownership
interests of such corporation are, or voting control is, transferred (but excepting transfers upon deaths of individual owners) from a person or persons or entity or entities which were owners thereof at time of execution of this Lease to persons or
entities who were not owners of shares or other ownership interests of the corporation, partnership or limited liability company at time of execution of this Lease, shall be deemed an assignment of this Lease requiring the consent of Landlord as
provided 

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in this Section 18. Notwithstanding the foregoing, any public offering of shares or other ownership interest in Tenant or any private equity financing by one or more investors who
regularly invest in private biotechnology companies, for which Tenant has given Landlord prior (to the extent prior notice is permitted by applicable law) or concurrent written notice, shall not be deemed an assignment. Such prior written notice
shall be treated by Landlord as confidential information. 
 (b) Permitted Transfers. If Tenant desires to assign, sublease (in whole
or in part), hypothecate or otherwise transfer this Lease or sublet the Premises, other than pursuant to a Permitted Assignment (as defined below), then at least 15 business days, but not more than 45 business days, before the date Tenant desires
the assignment or sublease to be effective (the “Assignment Date”), Tenant shall give Landlord a notice (the “Assignment Notice”) containing such information about the proposed assignee or sublessee, including the
proposed use of the Premises and any Hazardous Materials proposed to be used, stored handled, treated, generated in or released or disposed of from the Premises, the Assignment Date, any relationship between Tenant and the proposed assignee or
sublessee, and all material terms and conditions of the proposed assignment or sublease, including a copy of any proposed assignment or sublease in its final form, and such other information as Landlord may deem reasonably necessary or appropriate
to its consideration whether to grant its consent. Landlord may, by giving written notice to Tenant within 15 business days after receipt of the Assignment Notice: (i) grant such consent, (ii) refuse such consent, in its sole and absolute
discretion, to any proposed assignment, hypothecation or other transfer other than a subletting, (iii) refuse such consent, in its reasonable discretion, to a proposed subletting (provided that Landlord shall further have the right to review
and approve or disapprove the proposed form of sublease prior to the effective date of any such subletting), or (iv) with respect to any proposed assignment, hypothecation or transfer, or with respect to any proposed subletting for the
remainder of the Term of more than 50% of the Premises (taken together with any prior sublettings), terminate this Lease with respect to the space described in the Assignment Notice as of the Assignment Date (an “Assignment
Termination”). If Landlord delivers notice of its election to exercise an Assignment Termination, Tenant shall have the right to withdraw such Assignment Notice by written notice to Landlord of such election within 5 business days after
Tenant’s receipt of Landlord’s notice electing to exercise the Assignment Termination. If Tenant withdraws such Assignment Notice, this Lease shall continue in full force and effect. If Tenant does not withdraw such Assignment Notice, this
Lease, and the term and estate herein granted, shall terminate as of the Assignment Date with respect to the space described in such Assignment Notice. No failure of Landlord to exercise any such option to terminate this Lease, or to deliver a
timely notice in response to the Assignment Notice, shall be deemed to be Landlord’s consent to the proposed assignment, sublease or other transfer. Tenant shall pay to Landlord a fee equal to One Thousand Five Hundred Dollars ($1,500) in
connection with its consideration of any Assignment Notice and/or its preparation or review of any consent documents. 
 (c) In considering
whether or not to consent to any proposed sublease under clause (iii) of Section 18(b) above, Landlord shall be deemed to have acted reasonably if consent is refused for any of the following reasons: (A) the business or
financial reputation of the proposed sublessee, or the business or financial reputation of any of the respective principals or officers thereof, is objectionable in Landlord’s judgment, (B) the proposed sublessee is engaged in areas of
scientific research or other business concerns that are reasonably likely in Landlord’s judgment to attract negative publicity about, or protest at, the Building, or its proposed use of the Premises will violate any applicable Legal
Requirement, (C) the proposed sublessee is at that time an occupant of the Project (and Landlord has comparable available space in the Project) or negotiating with Landlord or an affiliate thereof for the lease of other space in the Project,
(D) the proposed sublessee does not have a creditworthiness, as of the date of transfer, sufficient to support the financial obligations it would incur under the proposed sublease in Landlord’s judgment, (E) the proposed sublessee is a
governmental agency, (F) in Landlord’s judgment the use of the Premises by the proposed sublessee would entail any alterations that would lessen the value of the leasehold improvements in the Premises, or would require increased services
by Landlord, (G) Landlord has received from any other landlord to the proposed sublessee a negative report concerning such other landlord’s experience with the proposed sublessee, (H) Landlord has experienced previous defaults by or
is in litigation with the proposed sublessee, (I) the proposed sublease will create a vacancy elsewhere in the Project or at any other property owned in whole or in part by Landlord or any of its affiliates and located in Massachusetts, or
(J) the sublease is prohibited by Landlord’s lender, if any. 

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 (d) Notwithstanding
the foregoing, (i) Landlord’s consent to an assignment of this Lease or a subletting of any portion of the Premises to any entity controlling, controlled by or under common control with Tenant shall not be required, provided that Landlord
shall have the right to reasonably approve the form of any such sublease or assignment; and (ii) Tenant shall have the right to assign this Lease, upon 10 days prior written notice to Landlord but without obtaining Landlord’s prior written
consent, to a corporation or other entity which is a successor-in-interest to Tenant, by way of merger, consolidation or corporate reorganization, or by the purchase of all or substantially all of the assets or the ownership interests of Tenant
provided that (i) such merger or consolidation, or such acquisition or assumption, as the case may be, is for a good business purpose and not principally for the purpose of transferring the Lease, and (ii) the net worth (as determined in
accordance with generally accepted accounting principles (“GAAP”)) of the assignee is not less than the net worth (as determined in accordance with GAAP) of Tenant as of the date of Tenant’s most current quarterly or annual
financial statements, and (iii) such assignee shall agree in writing to assume all of the terms, covenants and conditions of this Lease arising after the effective date of the assignment. The subletting and assignment described in clauses
(i) and (ii) of this paragraph are referred to as a “Permitted Assignment.” 
 (e) Additional Conditions.
As a condition to any such assignment or subletting, whether or not Landlord’s consent is required, Landlord may require: 

(i) that any assignee or subtenant agree, in writing at the time of such assignment or subletting, that if Landlord gives such
party notice that Tenant is in Default under this Lease, such party shall thereafter make all payments otherwise due Tenant directly to Landlord, which payments will be received by Landlord without any liability except to credit such payment against
those due under the Lease, and any such third party shall agree to attorn to Landlord or its successors and assigns should this Lease be terminated for any reason; provided, however, in no event shall Landlord or its successors or
assigns be obligated to accept such attornment; and 
 (ii) a list of Hazardous Materials, certified by the proposed assignee
or sublessee to be true and correct, which the proposed assignee or sublessee intends to use, store, handle, treat, generate in or release or dispose of from the Premises, together with copies of all documents relating to such use, storage,
handling, treatment, generation, release or disposal of Hazardous Materials by the proposed assignee or subtenant in the Premises or on the Project, prior to the proposed assignment or subletting, including, without limitation: permits; approvals;
reports and correspondence; storage and management plans; plans relating to the installation of any storage tanks to be installed in or under the Project (provided, said installation of tanks shall only be permitted after Landlord has given its
written consent to do so, which consent may be withheld in Landlord’s sole and absolute discretion); and all closure plans or any other documents required by any and all federal, state and local Governmental Authorities for any storage tanks
installed in, on or under the Project for the closure of any such tanks. Neither Tenant nor any such proposed assignee or subtenant is required, however, to provide Landlord with any portion(s) of the such documents containing information of a
proprietary nature which, in and of themselves, do not contain a reference to any Hazardous Materials or hazardous activities. 
 (f) No
Release of Tenant, Sharing of Excess Rents. Notwithstanding any assignment or subletting, Tenant and any guarantor or surety of Tenant’s obligations under this Lease shall at all times remain fully and primarily responsible and liable for
the payment of Rent and for compliance with all of Tenant’s other obligations under this Lease. If the Rent due and payable by a sublessee or assignee (or a combination of the rental payable under such sublease or assignment plus any bonus or
other consideration therefor or incident thereto in any form) exceeds the sum of the rental payable under this Lease, which shall be prorated for a sublease of less than all of the Premises (excluding however, any Rent payable under this Section)
and actual and reasonable brokerage fees, free rent included as an inducement, legal costs and any design or construction fees directly related to and required pursuant to 

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the terms of any such sublease or any reasonable services fees payable by subtenant to Tenant for the costs to Tenant to provide typical office services such as coffee machines, telephones and
fax machines (“Excess Rent”), then Tenant shall be bound and obligated to pay Landlord as Additional Rent hereunder 50% of such Excess Rent within 10 days following receipt thereof by Tenant. If Tenant shall sublet the Premises or
any part thereof, Tenant hereby immediately and irrevocably assigns to Landlord, as security for Tenant’s obligations under this Lease, all rent from any such subletting, and Landlord as assignee and as attorney-in-fact for Tenant, or a
receiver for Tenant appointed on Landlord’s application, may collect such rent and apply it toward Tenant’s obligations under this Lease; except that, until the occurrence of a Default, Tenant shall have the right to collect such rent.

 (g) No Waiver. The consent by Landlord to an assignment or subletting shall not relieve Tenant or any assignees of this Lease or
any sublessees of the Premises from obtaining the consent of Landlord to any further assignment or subletting nor shall it release Tenant or any assignee or sublessee of Tenant from full and primary liability under the Lease. The acceptance of Rent
hereunder, or the acceptance of performance of any other term, covenant, or condition thereof, from any other person or entity shall not be deemed to be a waiver of any of the provisions of this Lease or a consent to any subletting, assignment or
other transfer of the Premises. 
 (h) Prior Conduct of Proposed Transferee. Notwithstanding any other provision of this
Section 18, if (i) the proposed assignee or sublessee of Tenant has been required by any prior landlord, lender or Governmental Authority to take remedial action in connection with Hazardous Materials contaminating a property, where
the contamination resulted from such party’s action or use of the property in question, (ii) the proposed assignee or sublessee is subject to an enforcement order issued by any Governmental Authority in connection with the use, storage,
handling, treatment, generation, release or disposal of Hazardous Materials (including, without limitation, any order related to the failure to make a required reporting to any Governmental Authority), or (iii) because of the existence of a
pre-existing environmental condition in the vicinity of or underlying the Project, the risk that Landlord would be targeted as a responsible party in connection with the remediation of such pre-existing environmental condition would be materially
increased or exacerbated by the proposed use of Hazardous Materials by such proposed assignee or sublessee, Landlord shall have the absolute right to refuse to consent to any assignment or subletting to any such party. 

19. Estoppel Certificate. Tenant shall, within 10 business days of written notice from Landlord, execute, acknowledge and deliver an
estoppel certificate on any form reasonably requested by a proposed lender or purchaser. 
 20. Quiet Enjoyment. So long as Tenant
shall perform all of the covenants and agreements herein required to be performed by Tenant, Tenant shall, subject to the terms of this Lease, at all times during the Term, have peaceful and quiet enjoyment of the Premises against any person
claiming by, through or under Landlord. 
 21. Prorations. All prorations required or permitted to be made hereunder shall be made on
the basis of a 360-day year and 30-day months. 
 22. Rules and Regulations. Tenant shall, at
all times during the Term and any extension thereof, comply with all reasonable rules and regulations at any time or from time to time established by Landlord covering use of the Premises and the Project. The current rules and regulations are
attached hereto as Exhibit I. If there is any conflict between said rules and regulations and other provisions of this Lease, the terms and provisions of this Lease shall control. Landlord shall not have any liability or obligation for the
breach of any rules or regulations by other tenants in the Project and shall not enforce such rules and regulations in a discriminatory manner. 

23. Subordination. This Lease and Tenant’s interest and rights hereunder are and shall be subject and subordinate at all times to
the lien of any Mortgage now existing or hereafter created on or against the Project or the Premises, and all amendments, restatements, renewals, modifications, 

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consolidations, refinancing, assignments and extensions thereof, without the necessity of any further instrument or act on the part of Tenant. Tenant agrees, at the election of the Holder of any
such Mortgage, to attorn to any such Holder. Tenant agrees within 10 business days after demand to execute, acknowledge and deliver such instruments confirming such subordination and/or attornment as shall be reasonably requested by any such Holder.
Upon request of Tenant, Landlord shall use commercially reasonable efforts to obtain from any future Holder of a Mortgage on the Project, if any, an agreement of non-disturbance, which agreement may also contain provisions for subordination,
attornment and other terms and conditions of Holder. The term “Mortgage” whenever used in this Lease shall be deemed to include deeds of trust, security assignments, ground leases or other superior leases and any other encumbrances,
and any reference to the “Holder” of a Mortgage shall be deemed to include the beneficiary under a deed of trust. Landlord represents that the Project is currently not encumbered by a Mortgage as of the date of this Lease. 

24. Surrender. Upon the expiration of the Term or earlier termination of Tenant’s right of possession, Tenant shall surrender the
Premises to Landlord in the same condition as received, subject to any Alterations or Installations permitted by Landlord to remain in the Premises, free of Hazardous Materials brought upon, kept, used, stored, handled, treated, generated in, or
released or disposed of from, the Premises by any person other than a Landlord Party, broom clean, ordinary wear and tear and casualty loss and condemnation covered by Sections 15 excepted. 

Tenant shall immediately return to Landlord all keys and/or access cards to parking, the Project, restrooms or all or any portion of the
Premises furnished to or otherwise procured by Tenant. If any such access card or key is lost, Tenant shall pay to Landlord, at Landlord’s election, either the cost of replacing such lost access card or key or the cost of reprogramming the
access security system in which such access card was used or changing the lock or locks opened by such lost key. Any Tenant’s Property, Alterations and property not so removed by Tenant as permitted or required herein shall be deemed abandoned
and may be stored, removed, and disposed of by Landlord at Tenant’s expense, and Tenant waives all claims against Landlord for any damages resulting from Landlord’s retention and/or disposition of such property. All obligations of Tenant
hereunder not fully performed as of the termination of the Term, including the obligations of Tenant under Section 26 hereof, shall survive the expiration or earlier termination of the Term, including, without limitation, indemnity
obligations, payment obligations with respect to Rent and obligations concerning the condition and repair of the Premises. 
 25. Waiver
of Jury Trial. TENANT AND LANDLORD WAIVE ANY RIGHT TO TRIAL BY JURY OR TO HAVE A JURY PARTICIPATE IN RESOLVING ANY DISPUTE, WHETHER SOUNDING IN CONTRACT, TORT, OR OTHERWISE, BETWEEN LANDLORD AND TENANT ARISING OUT OF THIS LEASE OR ANY OTHER
INSTRUMENT, DOCUMENT, OR AGREEMENT EXECUTED OR DELIVERED IN CONNECTION HEREWITH OR THE TRANSACTIONS RELATED HERETO. 
 26. Environmental
Requirements. 
 (a) Generally. Except for Hazardous Material contained in products customarily used by tenants in de minimis
quantities for ordinary cleaning and office purposes, Tenant shall not permit or cause any party to bring any Hazardous Material upon the Premises or the Project or use, store, handle, treat, generate, manufacture, transport, release or dispose of
any Hazardous Material in, on or from the Premises or the Project without Landlord’s prior written consent which may be withheld in Landlord’s sole discretion. Tenant, at its sole cost and expense, shall operate its business in the
Premises in strict compliance with all Environmental Requirements and shall remove or remediate in a manner satisfactory to Landlord any Hazardous Materials released on or from the Project by Tenant or any Tenant Party. Tenant shall complete and
certify disclosure statements as requested by Landlord from time to time relating to Tenant’s use, storage, handling, treatment, generation, manufacture, transportation, release or disposal of Hazardous Materials on or from the Premises. The
term “Environmental Requirements” means all applicable present and future statutes, regulations, ordinances, rules, codes, judgments, orders or other similar enactments of any Governmental Authority regulating or relating to health,
safety, or environmental conditions on, under, or about the Premises or the Project, or the environment, including 

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without limitation, the following: the Comprehensive Environmental Response, Compensation and Liability Act; the Resource Conservation and Recovery Act, and all state and local counterparts
thereto, and any regulations or policies promulgated or issued thereunder. The term “Hazardous Materials” means and includes any substance, material, waste, pollutant, or contaminant listed or defined as hazardous or toxic, or
regulated by reason of its impact or potential impact on humans, animals and/or the environment under any Environmental Requirements, asbestos and petroleum, including crude oil or any fraction thereof, natural gas liquids, liquefied natural gas, or
synthetic gas usable for fuel (or mixtures of natural gas and such synthetic gas). As defined in Environmental Requirements, Tenant is and shall be deemed to be the “operator” of Tenant’s “facility” and the
“owner” of all Hazardous Materials brought on the Premises by Tenant or any Tenant Party, and the wastes, by-products, or residues generated, resulting, or produced therefrom. 

(b) Indemnity. Tenant hereby indemnifies and shall defend and hold Landlord and each of the Landlord Parties harmless from any and all
actions (including, without limitation, remedial or enforcement actions of any kind, administrative or judicial proceedings, and orders or judgments arising out of or resulting therefrom), costs, claims, damages (including, without limitation,
punitive damages and damages based upon diminution in value of the Premises or the Project, or the loss of, or restriction on, use of the Premises or any portion of the Project), expenses (including, without limitation, attorneys’,
consultants’ and experts’ fees, court costs and amounts paid in settlement of any claims or actions), fines, forfeitures or other civil, administrative or criminal penalties, injunctive or other relief (whether or not based upon personal
injury, property damage, or contamination of, or adverse effects upon, the environment, water tables or natural resources), liabilities or losses (collectively, “Environmental Claims”) which arise during or after the Term as a
result of such breach by Tenant of its obligations stated in the preceding sentence or as a result of such contamination. This indemnification of Landlord by Tenant includes, without limitation, costs incurred in connection with any investigation of
site conditions or any cleanup, remedial, removal, or restoration work required by any federal, state or local Governmental Authority because of Hazardous Materials present in the air, soil or ground water above, on, or under the Premises. Without
limiting the foregoing, if the presence of any Hazardous Materials on the Premises, the Project or any adjacent property caused or permitted by Tenant or any Tenant Party results in any contamination of the Premises, the Project or any adjacent
property. Tenant shall promptly take all actions at its sole expense and in accordance with applicable law as are necessary to return the Premises, the Project or any adjacent property to the condition existing prior to the time of such
contamination, provided that Landlord’s approval of such action shall first be obtained, which approval shall not unreasonably be withheld so long as such actions would not potentially have any material adverse long-term or short-term effect on
the Premises or the Project. Notwithstanding anything to the contrary contained in this Section 26(b), Tenant shall not be responsible for the clean up or remediation of, and the indemnification and hold harmless obligation set forth in
this paragraph shall not apply to contamination on the Project or in the Premises that Tenant can demonstrate to Landlord’s reasonable satisfaction was present on the Project or in the Premises prior to the date of this Lease or in the case of
contamination in the Shared Conference Facility was not caused by an act or omission of Tenant, except in any case to the extent Tenant and/or any of the Tenant Parties have exacerbated or contributed to such contamination, and provided that it is
understood that Tenant shall have the burden of proof with respect to whether such contamination was present on the Project or in the Premises prior to the date of this Lease or whether such contamination in the Shared Conference Facility was not
caused by an act or omission of Tenant. 
 (c) Landlord’s Tests. Landlord shall have access to, and a right to perform
inspections and tests of the Premises to determine Tenant’s compliance with Environmental Requirements, its obligations under this Section 26, or the environmental condition of the Premises or the Project. In connection with such
testing, upon the request of Landlord, Tenant shall deliver to Landlord or its consultant such nonproprietary information concerning the use of Hazardous Materials in or about the Premises by Tenant or any Tenant Party. Access to the Premises shall
be granted to Landlord upon Landlord’s prior notice to Tenant and at such times so as to minimize, so far as may be reasonable under the circumstances, any disturbance to Tenant’s operations. Such inspections and tests shall be conducted
at Landlord’s expense, unless such inspections or tests reveal that Tenant has not complied with any Environmental 

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Requirement, in which case Tenant shall reimburse Landlord for the reasonable cost of such inspection and tests. Tenant shall, at its sole cost and expense, promptly and satisfactorily remediate
any environmental conditions for which Tenant is responsible pursuant to this Section 26 and that are identified by such testing in accordance with all Environmental Requirements. Landlord’s receipt of or satisfaction with any
environmental assessment in no way waives any rights that Landlord may have against Tenant. 
 (d) Tenant’s Obligations.
Tenant’s obligations under this Section 26 shall survive the expiration or earlier termination of the Lease. During any period of time after the expiration or earlier termination of this Lease required by Tenant or Landlord to
complete the removal from the Premises of any Hazardous Materials for which Tenant is responsible under this Lease (including, without limitation, the release and termination of any licenses or permits restricting the use of the Premises and the
completion of the approved Surrender Plan), Tenant shall continue to pay the full Rent in accordance with this Lease for any portion of the Premises not relet by Landlord in Landlord’s sole discretion, which Rent shall be prorated daily. 

(e) Asbestos. 

(i) Notification of Asbestos. Landlord hereby notifies Tenant of the presence of asbestos-containing materials
(“ACMs”) and/or presumed asbestos-containing materials (“PACMs”) within or about the Premises in the locations identified in Exhibit J attached hereto. 

(ii) Tenant Acknowledgement. Tenant hereby acknowledges receipt of the notification in paragraph (i) of this
Section 26 and understand that the purpose of such notification is to make Tenant, and any agents, employees, and contractors of Tenant, aware of the presence of ACMs and/or PACMs within or about the Building in order to avoid or
minimize any damage to or disturbance of such ACMs and/or PACMs. 
  

					
		 	 

	 	
		 	Tenant’s Initials	 	

 (iii) Acknowledgement from Contractors/Employees. Tenant shall give Landlord at least 14
days’ prior written notice before conducting, authorizing or permitting any of the activities listed below within or about the Premises, and before soliciting bids from any person to perform such services. Such notice shall identify or describe
the proposed scope, location, date and time of such activities and the name, address and telephone number of each person who may be conducting such activities. Thereafter, Tenant shall grant Landlord reasonable access to the Premises to determine
whether any ACMs or PACMs will be disturbed in connection with such activities. Tenant shall not solicit bids from any person for the performance of such activities without Landlord’s prior written approval (such approval not to be unreasonably
withheld). Upon Landlord’s request, Tenant shall deliver to Landlord a copy of a signed acknowledgement from any contractor, agent, or employee of Tenant acknowledging receipt of information describing the presence of ACMs and/or PACMs within
or about the Premises in the locations identified in Exhibit J prior to the commencement of such activities. Nothing in this Section 26 shall be deemed to expand Tenant’s rights under the Lease or otherwise to conduct,
authorize or permit any such activities. 
 (A) Removal of thermal system insulation (“TSI”) and surfacing
ACMs and PACMs (i.e., sprayed-on or troweled-on material, e.g., textured ceiling paint or fireproofing material); 
 (B)
Removal of ACMs or PACMs that are not TSI or surfacing ACMs or PACMs; or 
 (C) Repair and maintenance of operations that are
likely to disturb ACMs or PACMs. 

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 27. Tenant’s
Remedies/Limitation of Liability. Landlord shall not be in default hereunder unless Landlord fails to perform any of its obligations hereunder within 30 days after written notice from Tenant specifying such failure (unless such performance will,
due to the nature of the obligation, require a period of time in excess of 30 days, then after such period of time as is reasonably necessary), provided, however, that if the nature of Landlord’s obligation arises from an emergency condition
and Tenant provides notice to Landlord (which may be telephonic if followed by written notice on the same day describing the emergency condition in reasonable detail, including without limitation the emergency nature of the condition and specifying
in all capital letters and boldface type that the condition is an emergency and response is required by Landlord pursuant to the Lease), then Landlord shall respond within a reasonable period after receipt of such notice of the emergency condition.
Upon any default by Landlord, Tenant shall give notice by registered, certified or overnight mail to any Holder of a Mortgage covering the Premises and to any landlord of any lease of property in or on which the Premises are located and Tenant shall
offer such Holder and/or landlord a reasonable opportunity to cure the default, including time to obtain possession of the Project by power of sale or a judicial action if such should prove necessary to effect a cure; provided Landlord shall
have furnished to Tenant in writing the names and addresses of all such persons who are to receive such notices. All obligations of Landlord hereunder shall be construed as covenants, not conditions; and, except as may be otherwise expressly
provided in this Lease, Tenant may not terminate this Lease for breach of Landlord’s obligations hereunder. 
 28. Inspection and
Access. Subject to the next sentence, Landlord and its agents, representatives, and contractors may enter the Premises at any reasonable time to inspect the Premises and to make such repairs as may be required or permitted pursuant to this
Lease, to perform such environmental tests as may be reasonably required to confirm Tenant’s compliance with the terms hereof and for any other business purpose. Landlord and Landlord’s representatives may enter the Premises during
business hours on not less than 48 hours advance written notice (except in the case of emergencies in which case no such notice shall be required and such entry may be at any time) for the purpose of effecting any such repairs, inspecting the
Premises, showing the Premises to prospective purchasers and, during the last year of the Term, to prospective tenants or for any other business purpose. 

29. Security. Tenant acknowledges and agrees that security devices and services, if any, while intended to deter crime may not in given
instances prevent theft or other criminal acts and that Landlord is not providing any security services with respect to the Premises, Shared Conference Facility or Common Areas. Tenant agrees that Landlord shall not be liable to Tenant for, and
Tenant waives any claim against Landlord with respect to, any loss by theft or any other damage suffered or incurred by Tenant in connection with any unauthorized entry into the Premises, Shared Conference Facility or Common Areas or any other
breach of security with respect to the Premises, Shared Conference Facility, Common Areas or other portion of the Project. Tenant shall be solely responsible for the personal safety of Tenant’s officers, employees, agents, contractors, guests
and invitees while any such person is in, on or about the Premises and/or the Project. Tenant shall at Tenant’s cost obtain insurance coverage to the extent Tenant desires protection against such criminal acts. 

30. No Broker; Entire Agreement; Amendment. Landlord and Tenant each represents and warrants that it has not dealt with any broker,
agent or other person (collectively, “Broker) in connection with this transaction and that no Broker brought about this transaction, other than Cushman & Wakefield of Massachusetts and Richards Barry Joyce & Partners,
whose commission shall be paid by Landlord pursuant to a separate agreement. Landlord and Tenant each hereby agree to indemnify and hold the other harmless from and against any claims by any Broker, other than the broker, if any named in this
Section 30, claiming a commission or other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this leasing transaction. This Lease constitutes the entire agreement between Landlord and
Tenant pertaining to the lease of the Premises and supersedes all other agreements, whether oral or written, pertaining to the lease of the Premises, and no other 

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agreements with respect thereto shall be effective. Any amendments or modifications of this Lease shall be in writing and signed by both Landlord and Tenant, and any other attempted amendment or
modification of this Lease shall be void. 
 31. Limitation on Landlord’s Liability. NOTWITHSTANDING ANYTHING SET FORTH HEREIN
OR IN ANY OTHER AGREEMENT BETWEEN LANDLORD AND TENANT TO THE CONTRARY: (A) LANDLORD SHALL NOT BE LIABLE TO TENANT OR ANY OTHER PERSON FOR (AND TENANT AND EACH SUCH OTHER PERSON ASSUME ALL RISK OF) LOSS, DAMAGE OR INJURY, WHETHER ACTUAL OR
CONSEQUENTIAL TO: TENANT’S PERSONAL PROPERTY OF EVERY KIND AND DESCRIPTION, INCLUDING, WITHOUT LIMITATION TRADE FIXTURES EQUIPMENT, INVENTORY, SCIENTIFIC RESEARCH, SCIENTIFIC EXPERIMENTS, LABORATORY ANIMALS, PRODUCT, SPECIMENS, SAMPLES, AND/OR
SCIENTIFIC, BUSINESS, ACCOUNTING AND OTHER RECORDS OF EVERY KIND AND DESCRIPTION KEPT AT THE PREMISES AND ANY AND ALL INCOME DERIVED OR DERIVABLE THEREFROM; (B) THERE SHALL BE NO PERSONAL RECOURSE TO LANDLORD FOR ANY ACT OR OCCURRENCE IN, ON OR
ABOUT THE PREMISES OR ARISING IN ANY WAY UNDER THIS LEASE OR ANY OTHER AGREEMENT BETWEEN LANDLORD AND TENANT WITH RESPECT TO THE SUBJECT MATTER HEREOF AND ANY LIABILITY OF LANDLORD HEREUNDER SHALL BE STRICTLY LIMITED SOLELY TO LANDLORD’S
INTEREST IN THE PROJECT OR ANY PROCEEDS FROM SALE OR CONDEMNATION THEREOF AND ANY INSURANCE PROCEEDS PAYABLE IN RESPECT OF LANDLORD’S INTEREST IN THE PROJECT OR IN CONNECTION WITH ANY SUCH LOSS; AND (C) IN NO EVENT SHALL ANY PERSONAL
LIABILITY BE ASSERTED AGAINST LANDLORD OR ITS OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS IN CONNECTION WITH THIS LEASE NOR SHALL ANY RECOURSE BE HAD TO ANY OTHER PROPERTY OR ASSETS OF LANDLORD OR ANY OF LANDLORD’S OFFICERS,
DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS. UNDER NO CIRCUMSTANCES SHALL LANDLORD OR ANY OF LANDLORD’S OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS BE LIABLE FOR INJURY TO TENANT’S BUSINESS OR FOR ANY LOSS OF INCOME OR PROFIT
THEREFROM. 
 32. Severability. If any clause or provision of this Lease is illegal, invalid or unenforceable under present or future
laws, then and in that event, it is the intention of the parties hereto that the remainder of this Lease shall not be affected thereby. 

33. Signs; Exterior Appearance. Tenant shall not: (i) attach anything at any time to any outside wall of the Project,
(ii) use any window coverings or sunscreen other than Landlord’s standard window coverings, (iii) place any articles on the window sills, (iv) place any items on any exterior balcony, or (v) paint, affix or exhibit any signs
or any kind in the Premises which can be viewed from the exterior of the Premises. Interior signs on doors, signage at the entrance of the Premises and the directory tablet, in each case in Building standard form, shall be provided by Landlord at
Landlord’s sole cost and expense. 
 34. Right to Extend Term. Tenant shall have the right to extend the Term of the Lease upon
the following terms and conditions: 
 (a) Extension Right. Tenant shall have 1 right (the “Extension Right”) to
extend the term of this Lease for 3 years (the “Extension Term”) on the same terms and conditions as this Lease (other than Base Rent) by giving Landlord written notice of its election to exercise the Extension Right at least 9
months prior to the expiration of the original Term of the Lease. Promptly after receipt of Tenant’s exercise notice, Landlord shall provide Tenant with Landlord’s determination of the Market Rate for the Extension Term. 

Upon the commencement of the Extension Term, Base Rent shall be payable at 95% of the Market Rate (as defined below). Base Rent shall
thereafter be adjusted on each annual anniversary of the commencement of such Extension Term by a percentage as determined by Landlord and agreed to by Tenant at the time the Market Rate is determined. As used herein, “Market Rate”
shall mean the then market rental rate for office space in East Cambridge of comparable age, quality, level of finish and 

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proximity to amenities and public transit. The Market Rate shall initially be determined by Landlord and submitted to Tenant for its consideration. If, on or before the date which is 120 days
prior to the expiration of the original Term of this Lease, Tenant has not agreed with Landlord’s determination of the Market Rate after negotiating in good faith, Tenant may by written notice to Landlord not later than 120 days prior to the
expiration of the original Term of this Lease, elect arbitration as described in Section 34(b) below. If Tenant has not agreed with Landlord’s determination of the Market Rate and does not elect such arbitration prior to the date
that is 120 days prior to the expiration of the original Term, Tenant shall be deemed to have waived any right to extend. 
 (b)
Arbitration. Within 10 days of Tenant’s notice to Landlord of its election to arbitrate Market Rate and escalations, each party shall deliver to the other a proposal containing the Market Rate and escalations that the submitting party
believes to be correct (“Extension Proposal”). If either party fails to timely submit an Extension Proposal, the other party’s submitted proposal shall determine the Base Rent and escalations for the Extension Term. If both
parties submit Extension Proposals, then Landlord and Tenant shall meet within 7 days after delivery of the last Extension Proposal and make a good faith attempt to mutually appoint a single Arbitrator (and defined below) to determine the Market
Rate and escalations. If Landlord and Tenant are unable to agree upon a single Arbitrator, then each shall, by written notice delivered to the other within 10 days after the meeting, select an Arbitrator. If either party fails to timely give notice
of its selection for an Arbitrator, the other party’s submitted proposal shall determine the Base Rent for the Extension Term. The 2 Arbitrators so appointed shall, within 5 business days after their appointment, appoint a third Arbitrator. If
the 2 Arbitrators so selected cannot agree on the selection of the third Arbitrator within the time above specified, then either party, on behalf of both parties, may request such appointment of such third Arbitrator by application to any state
court of general jurisdiction in the jurisdiction in which the Premises are located, upon 10 days prior written notice to the other party of such intent. 

The decision of the Arbitrator(s) shall be made within 30 days after the appointment of a single Arbitrator or the third Arbitrator, as
applicable. The decision of the single Arbitrator shall be final and binding upon the parties. The average of the two closest Arbitrators in a three Arbitrator panel shall be final and binding upon the parties. Each party shall pay the fees and
expenses of the Arbitrator appointed by or on behalf of such party and the fees and expenses of the third Arbitrator shall be borne equally by both parties. If the Market Rate and escalations not determined by the first day of the Extension Term,
then Tenant shall pay Landlord Base Rent in an amount equal to the Base Rent in effect immediately prior to the Extension Term and increased by the Rent Adjustment Percentage until such determination is made. After the determination of the Market
Rate and escalations, the parties shall make any necessary adjustments to such payments made by Tenant. Landlord and Tenant shall then execute an amendment recognizing the Market Rate and escalations for the Extension Term. 

An “Arbitrator” shall be any person appointed by or on behalf of either party or appointed pursuant to the provisions hereof
and: (i) shall be (A) a member of the American Institute of Real Estate Appraisers with not less than 10 years of experience in the appraisal of improved office and high tech or life sciences space in the greater Boston metropolitan area,
or (B) a licensed commercial real estate broker with not less than 15 years experience representing landlords and/or tenants in the leasing of improved office and high tech or life sciences space in the greater Boston metropolitan area,
(ii) devoting substantially all of their time to professional appraisal or brokerage work, as applicable, at the time of appointment and (iii) be in all respects impartial and disinterested. 

(c) Rights Personal. The Extension Right is personal to Tenant (and successors pursuant to a Permitted Assignment) and not assignable
without Landlord’s consent, which may be granted or withheld in Landlord’s sole discretion separate and apart from any consent by Landlord to an assignment of Tenant’s interest in the Lease. 

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 (d)
Exceptions. Notwithstanding anything set forth above to the contrary, the Extension Right shall not be in effect and Tenant may not exercise the Extension Right: 

(i) during any period of time that Tenant is in Default under any provision of this Lease; or 

(ii) if Tenant has been in Default under any provision of this Lease 3 or more times, whether or not the Defaults are cured,
during the 12 month period immediately prior to the date that Tenant intends to exercise the Extension Right, whether or not the Defaults are cured. 

(e) No Extensions. The period of time within which the Extension Right may be exercised shall not be extended or enlarged by reason of
Tenant’s inability to exercise the Extension Right. 
 (f) Termination. The Extension Right shall terminate and be of no further
force or effect even after Tenant’s due and timely exercise of the Extension Right, if, after such exercise, but prior to the commencement date of the Extension Term, (i) Tenant fails to timely cure any default by Tenant under this Lease;
or (ii) Tenant has Defaulted 3 or more times during the period from the date of the exercise of the Extension Right to the date of the commencement of the Extension Term, whether or not such Defaults are cured. 

35. Right of First Refusal. 

(a) Expansion in the Building. Subject to rights granted to other tenants of the Project prior to the date of this Lease, each time
during the Base Term that Landlord intends to accept a written proposal (the “Pending Deal”) to lease the Available Space (as hereinafter defined) to a third party, Landlord shall deliver to Tenant written notice (the
“Pending Deal Notice”) of the existence of such Pending Deal. For purposes of this Section 35(a), “Available Space” shall mean those certain portions of the second floor of the Project shown on
Exhibit A, which is not occupied by a tenant or which is occupied by an existing tenant whose lease is expiring within 6 months or less and such tenant does not wish to renew (whether or not such tenant has a right to renew) its occupancy of
such space. Tenant shall be entitled to exercise its right under this Section 35(a) only with respect to the entire Available Space described in such Pending Deal Notice. Within 5 business days after Tenant’s receipt of the Pending
Deal Notice, Tenant shall deliver to Landlord written notice (the “Space Acceptance Notice”) if Tenant elects to lease the Available Space. Tenant’s right to receive the Pending Deal Notice and election to lease or not lease
the Available Space pursuant to this Section 35(a) is hereinafter referred to as the “Right of First Refusal.” If Tenant elects to lease the Available Space described in the Pending Deal Notice by delivering the Space
Acceptance Notice within the required 5 business day period, Tenant shall be deemed to agree to lease the Available Space on the same general terms and conditions as this Lease except that the terms of this Lease shall be modified to reflect the
terms of the Pending Deal. The term of the Lease with respect to the Available Space shall be the term reflected in the Pending Deal, which Tenant acknowledges and agrees may not be co-terminous with the Term of this Lease with respect to the
Premises. Notwithstanding anything to the contrary contained herein, in no event shall the Work Letter apply to the Available Space. If Tenant fails to deliver a Space Acceptance Notice to Landlord within the required 5 business day period, Tenant
shall be deemed to have waived its rights under this Section 35(a) with respect to the Available Space identified in the Pending Deal Notice and Landlord shall have the right to lease such Available Space to the third party subject to
the Pending Deal (or an affiliate of such third party) (“Pending Deal Party”). Notwithstanding the foregoing, Tenant’s Right of First Refusal shall be restored if Landlord fails to enter into an agreement to lease the Available
Space to the Pending Deal Party within 6 months after Landlord’s delivery of the Pending Deal Notice to Tenant; provided, however, that in no event shall the Right of First Refusal continue after the expiration of the Base Term. In no event
shall Landlord be required to disclose the identity of any Pending Deal Party to Tenant. 
 (b) Amended Lease. If: (i) Tenant
fails to timely deliver a Space Acceptance Notice, or (ii) after the expiration of a period of 10 days after Landlord’s delivery to Tenant of a lease amendment or lease agreement for Tenant’s lease of the Available Space, no
lease amendment or lease agreement for the Available Space acceptable to both parties each in their sole and absolute discretion, has been executed, Tenant shall be deemed to have waived its right to lease such Available Space. 

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 (c)
Exceptions. Notwithstanding the above, the Right of First Refusal shall, at Landlord’s option, not be in effect and may not be exercised by Tenant: 

(i) during any period of time that Tenant is in Default under any provision of the Lease; or 

(ii) if Tenant has been in Default under any provision of the Lease 3 or more times, whether or not the Defaults are cured,
during the 12 month period prior to the date on which Tenant seeks to exercise the Right of First Refusal. 
 (d) Termination. The
Right of First Refusal shall, at Landlord’s option, terminate and be of no further force or effect even after Tenant’s due and timely exercise of the Right of First Refusal, if, after such exercise, but prior to the commencement date of
the lease of such Available Space, (i) Tenant fails to timely cure any Default by Tenant under the Lease; or (ii) Tenant has Defaulted 3 or more times during the period from the date of the exercise of the Right of First Refusal to the
date of the commencement of the lease of the Available Space, whether or not such Defaults are cured. 
 (e) Rights Personal. The
Right of First Refusal is personal to Tenant (and successors pursuant to a Permitted Assignment) and is not assignable without Landlord’s consent, which may be granted or withheld in Landlord’s sole discretion separate and apart from any
consent by Landlord to an assignment of Tenant’s interest in the Lease. 
 (f) No Extensions. The period of time within which
the Right of First Refusal may be exercised shall not be extended or enlarged by reason of Tenant’s inability to exercise the Right of First Refusal. 

36. Miscellaneous. 
 (a)
Notices. Except as otherwise provided herein, all notices or other communications between the parties shall be in writing and shall be deemed duly given upon delivery or refusal to accept delivery by the addressee thereof if delivered in
person, confirmed receipt by facsimile, or upon delivery if delivered by reputable overnight guaranty courier or certified mail return receipt requested, addressed and sent to the parties at their addresses set forth above. Landlord and Tenant may
from time to time by written notice to the other designate another address for receipt of future notices. 
 (b) Recordation. Neither
this Lease nor a memorandum of lease shall be filed by or on behalf of Tenant in any public record. Landlord may prepare and file, and upon request by Landlord Tenant will execute, a memorandum of lease. 

(c) Interpretation. The normal rule of construction to the effect that any ambiguities are to be resolved against the drafting party
shall not be employed in the interpretation of this Lease or any exhibits or amendments hereto. The captions inserted in this Lease are for convenience only and in no way define, limit or otherwise describe the scope or intent of this Lease, or any
provision hereof, or in any way affect the interpretation of this Lease. 
 (d) Not Binding Until Executed. The submission by
Landlord to Tenant of this Lease shall have no binding force or effect, shall not constitute an option for the leasing of the Premises, nor confer any right or impose any obligations upon either party until execution of this Lease by both parties.

 (e) Limitations on Interest. It is expressly the intent of Landlord and Tenant at all times to comply with applicable law
governing the maximum rate or amount of any interest payable on or in connection with this Lease. If applicable law is ever judicially interpreted so as to render usurious any interest called for under this Lease, or contracted for, charged, taken,
reserved, or received with respect to this Lease, then it is Landlord’s and Tenant’s express intent that all excess amounts theretofore 

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collected by Landlord be credited on the applicable obligation (or, if the obligation has been or would thereby be paid in full, refunded to Tenant), and the provisions of this Lease immediately
shall be deemed reformed and the amounts thereafter collectible hereunder reduced, without the necessity of the execution of any new document, so as to comply with the applicable law, but so as to permit the recovery of the fullest amount otherwise
called for hereunder. 
 (f) Choice of Law. Construction and interpretation of this Lease shall be governed by the internal laws of
the state in which the Premises are located, excluding any principles of conflicts of laws. 
 (g) Time. Time is of the essence as to
the performance of Tenant’s obligations under this Lease. 
 (h) Force Majeure. Except for the payment of Rent, neither Landlord
nor Tenant shall be held responsible or liable for delays in the performance of its obligations hereunder when caused by, related to, or arising out of acts of God, strikes, lockouts, or other labor disputes, embargoes, quarantines, weather,
national, regional, or local disasters, calamities, or catastrophes, inability to obtain labor or materials (or reasonable substitutes therefor) at reasonable costs or failure of, or inability to obtain, utilities necessary for performance,
governmental restrictions, orders, limitations, regulations, or controls, national emergencies, delay in issuance or revocation of permits, enemy or hostile governmental action, terrorism, insurrection, riots, civil disturbance or commotion, fire or
other casualty, and other causes or events beyond their reasonable control (individually or collectively, “Force Majeure”), it being understood that Force Majeure shall not include financial difficulties of Landlord or Tenant, if
any. 
 (i) Financial Information. Tenant shall furnish Landlord with true and complete copies of (i) Tenant’s most recent
audited annual financial statements within 90 days of the end of each of Tenant’s fiscal years during the Term, (ii) Tenant’s most recent unaudited quarterly financial statements within 45 days of the end of each of Tenant’s
first three fiscal quarters of each of Tenant’s fiscal years during the Term, (iii) at Landlord’s request from time to time but not more than once in any 12 month period, updated business plans, including cash flow projections and/or
pro forma balance sheets and income statements, all of which shall be treated by Landlord as confidential information belonging to Tenant, (iv) corporate brochures and/or profiles prepared by Tenant for prospective investors, and (v) any
other financial information or summaries that Tenant typically provides to its lenders or shareholders. Notwithstanding the foregoing, in no event shall Tenant be required to provide any financial information to Landlord which Tenant does not
otherwise prepare (or cause to be prepared) for its own purposes. 
 (j) OFAC. Tenant, and all beneficial owners of Tenant, are
currently (a) in compliance with, and shall at all times during the Term of this Lease remain in compliance with, the regulations of the Office of Foreign Assets Control (“OFAC”) of the U.S. Department of Treasury and any
statute, executive order, or regulation relating thereto (collectively, the “OFAC Rules”), (b) not listed on, and shall not during the Term of this Lease be listed on, the Specially Designated Nationals and Blocked Persons List
maintained by OFAC and/or on any other similar list maintained by OFAC or other governmental authority pursuant to any authorizing statute, executive order, or regulation, and (c) not a person or entity with whom a U.S. person is prohibited
from conducting business under the OFAC Rules. 
 (k) Incorporation by Reference. All exhibits and addenda attached hereto are hereby
incorporated into this Lease and made a part hereof. If there is any conflict between such exhibits or addenda and the terms of this Lease, such exhibits or addenda shall control, except in the case of conflict between the Rules and Regulations in
Exhibit I. In the event of any conflict between the Rules and Regulations in Exhibit I and the Lease, the Lease shall control. 

(l) No Accord and Satisfaction. No payment by Tenant or receipt by Landlord of a lesser amount than the monthly installment of Base
Rent or any Additional Rent will be other than on account of the earliest stipulated Base Rent and Additional Rent, nor will any endorsement or statement on any check or letter accompanying a check for payment of any Base Rent or Additional Rent be
an accord and satisfaction. Landlord may accept such check or payment without prejudice to Landlord’s right to recover the balance of such Rent or to pursue any other remedy provided in this Lease. 

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 (m) Hazardous
Activities. Notwithstanding any other provision of this Lease, Landlord, for itself and its employees, agents and contractors, reserves the right to refuse to perform any repairs or services in any portion of the Premises which, pursuant to
Tenant’s routine safety guidelines, practices or custom or prudent industry practices, require any form of protective clothing or equipment other than safety glasses. In any such case, Tenant shall contract with parties who are acceptable to
Landlord, in Landlord’s reasonable discretion, for all such repairs and services, and Landlord shall, to the extent required, equitably adjust Tenant’s Share of Operating Expenses in respect of such repairs or services to reflect that
Landlord is not providing such repairs or services to Tenant. 
 [ Signatures on next page ] 

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 IN WITNESS WHEREOF,
Landlord and Tenant have executed this Lease as of the day and year first above written. 
  

			
	TENANT:
	
	 SAGE THERAPEUTICS, INC.,
 a
Delaware corporation

		
	By:	 	 /s/ KEVIN STARR

	Its:	 	 KEVIN STARR, PRESIDENT

  

							
	LANDLORD:
	
	ARE-MA REGION NO. 38, LLC, a Delaware limited liability corporation
		
	By:	 	 Alexandria Real Estate Equities, L.P.,

a Delaware limited partnership,
 managing member

			
		 	By:	 	ARE-QRS Corp., a Maryland corporation, general partner
				
		 		 	By:	 	 /s/ Eric S. Johnson

		 		 	Its:	 	  

		 		 		 	Eric S. Johnson
		 		 		 	Vice President
		 		 		 	Real Estate Legal Affairs

 215 First/Sage - Page 1 

 
 EXHIBIT A TO LEASE 

DESCRIPTION OR PLAN OF PREMISES 
  

 

 215 First/Sage - Page 1 

 
 EXHIBIT B TO LEASE 

INTENTIONALLY OMITTED 

 215 First/Sage - Page 1 

 
 EXHIBIT C TO LEASE 

DESCRIPTION OR PLAN OF SHARED CONFERENCE FACILITY 
  

 

 215 First/Sage - Page 1 

 
 EXHIBIT D TO LEASE 

DESCRIPTION OF PROJECT 

A certain parcel of land with the buildings thereon, in Cambridge, Middlesex County, Massachusetts, known as and numbered 215 First Street,
and bounded and described as follows: 
 Beginning at the northwest corner of Athenaeum Street and First Street, said point being the
southeasterly corner of the parcel; 
 Thence running N 80 degrees 12’27” W, a distance of 399.30 feet along the northerly line of
said Athenaeum Street; 
 Thence turning and running N 09 degrees 43’10” E, a distance of 200.00 feet along the easterly line of
Second Street; 
 Thence turning and running S 80 degrees 12’27” E, a distance of 399.41 feet along the southerly line of Munroe
Street; 
 Thence turning and running S 09 degrees 45’06” W, a distance of 200.00 feet along the westerly line of First Street to
the point of beginning. 
 The above described parcel contains 79,871 square feet, more or less. 

 215 First/Sage - Page 1 

 
 EXHIBIT E TO LEASE 

LICENSE AGREEMENT 

THIS LICENSE AGREEMENT (this “Agreement”), dated as of
            , 2011, is made and entered into by and between ARE-MA REGION NO. 38, LLC, a Delaware limited liability company (“Licensor”), and SAGE THERAPEUTICS,
INC., a Delaware corporation (“Licensee”), with reference to the following Recitals: 
 RECITALS 

A. Licensor is the owner of that certain property commonly known as 215 First Street, Cambridge, Massachusetts (the
“Property”). 
 B. Concurrently herewith, Licensee and Licensor are entering into that certain Lease Agreement (the
“Lease”) for certain space located at the Property and more particularly described therein (the “Premises”). All initially capitalized terms used herein but not otherwise defined shall have the respective meanings
ascribed thereto in the Lease. 
 C. Licensee desires to have, and Licensor desires to grant to Licensee, certain rights to access
and use a certain area of the Property described as the “Shared Conference Facility” on Exhibit 1 attached hereto, all in accordance with the terms and provisions set forth below. 

AGREEMENT 
 For and in
consideration of the covenants and premises herein contained and other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, the parties hereby agree as follows: 

1. License; Scheduling and Fees for Shared Conference Facility. 

(a) License. Licensor hereby grants Licensee, and Licensee hereby accepts, a non-exclusive license to use the Shared Conference
Facility subject to the terms and provisions of this Agreement. 
 (b) Scheduling and Fees for Shared Conference Facility. Use
by Licensee of the Shared Conference Facility shall be in common with others entitled to use the Shared Conference Facility in accordance with scheduling procedures reasonably determined by Licensor. Licensor shall use commercially reasonable
efforts to schedule users on a first-come, first-served basis, but Licensor reserves the right to exercise its discretion in the event of conflicting scheduling requests among users. The first two occasions in a calendar month that Licensee uses the
Shared Conference Facility shall be at no charge for such use, and thereafter Licensee shall pay the hourly charges established by Licensor from time to time for use of the Shared Conference Facility. The current hourly charge for the use of the
Shared Conference Facility as of the date of this Lease is $200 per hour and is subject to change as determined by Licensor from time to time. Payment of such hourly charges shall be made within 10 days of invoice therefor, and Licensor reserves the
right to require an advance deposit from time to time. 
 2. Use. Licensee shall exercise its limited rights hereunder in compliance with all
laws, orders, judgments, ordinances, regulations, codes, directives, permits, licenses, covenants and restrictions now or hereafter applicable to the Property or Shared Conference Facility and the use and occupancy thereof, including the rules and
regulations attached as Exhibit 3 hereto, as the same may be revised by Licensor from time to time. 

 215 First/Sage - Page 2 

 
 3. Term. The term of this Agreement shall commence on the Commencement
Date set forth in the Lease (the “Commencement Date”) and continue until the earlier to occur of (a) the last day on which Licensee is entitled to occupy the Premises pursuant to the terms of the Lease, (b) the date this
Agreement is sooner terminated pursuant to its terms, and (c) the date the Lease is sooner terminated pursuant to its terms. The period between the Commencement Date and the date of termination of this Agreement shall be the
“Term.” 
 4. Relocation and Modification of Shared Conference Facility. Licensor shall have the right at any time to
reconfigure, relocate or modify the Shared Conference Facility from time to time and to revise or expand any of the services (if any) provided therein; provided, however, that such reconfiguration, relocation or modification of the respective
facility or any revision or expansion of services shall not materially adversely affect Tenant’s use of such facility or service as permitted pursuant to this Agreement. 

5. Interference. Licensee shall use the Shared Conference Facility in a manner that will not interfere with the rights of any tenants, other
licensees or Licensor’s service providers. Licensor assumes no responsibility for enforcing Licensee’s rights or for protecting the Shared Conference Facility from interference or use from any person, including, without limitation, tenants
or other licensees of the Property. 
 6. Default by Licensee. 

(a) It is mutually agreed that Licensee shall be in default hereunder (“Default”), 

(i) if Licensee fails to comply with any of the terms or provisions of this Agreement, and fails to cure such default within 30
days after the date of delivery of written notice of default from Licensor, provided that if the nature of such default is such that it cannot be cured by the payment of money and reasonably requires more than 30 days to cure, then Licensee shall
not be deemed to be in Default under this License if Licensee commences such cure within 30 days of the aforesaid notice from Licensor and thereafter diligently prosecutes such cure to completion within 90 days of the aforesaid notice from Licensor;
or 
 (ii) with respect to the Shared Conference Facility, if Licensee fails to pay any fees or charges for use of the Shared
Conference Facility or other amounts required hereunder when due pursuant to this Agreement; provided, however, that Licensor will give Licensee notice and an opportunity to cure any failure to pay such fees or charges within 3 business days of any
such notice not more than once in any 12 month period and Licensee agrees that such notice shall be in lieu of and not in addition to, or shall be deemed to be, any notice required by law or 

(iii) during the occurrence and continuation of any Default (as defined in the Lease) under the Lease. 

(b) In the event of any Default by Licensee hereunder, Licensor shall be entitled to all rights and remedies provided for Landlord under the
Lease, and all other rights and remedies provided at law or in equity, including without limitation, termination of this Agreement and the license granted hereunder. 

7. Indemnification and Limitation of Liability. 

(a) Licensor’s sole obligation for providing standby generators or any other standby power equipment, other equipment, systems,
furnishings or personal property to the Shared Conference Facility, whether or not affixed to the Building (collectively, “Equipment”) shall be (i) to provide such Equipment as is determined by Licensor in its sole and absolute
discretion, and (ii) to contract with a third party (determined by Licensor to be qualified) to maintain the Equipment that is deemed by Licensor (in its reasonable professional discretion) to need periodic maintenance per the
manufacturer’s standard 

 215 First/Sage - Page 3 

 
 
maintenance guidelines. Licensor shall have no obligation to provide Licensee with operational Equipment, back-up Equipment or back-up utilities or to supervise, oversee or confirm that the third
party maintaining the Equipment is maintaining the Equipment as per the manufacturer’s standard guidelines or otherwise. During any period of replacement, repair or maintenance of the Equipment when such Equipment is not operational, including
any delays thereto due to the inability to obtain parts or replacements, Licensor shall have no obligation to provide Licensee with alternative or back-up Equipment or alternative sources of utilities. Licensee expressly acknowledges and agrees that
Licensor does not guaranty that the Equipment will be operational at all times, will function or perform adequately, or that emergency power will be available to the Premises when needed, and Licensor shall not be liable for any damages resulting
from the failure of such Equipment. Licensee hereby releases Licensor from and against any and all claims arising directly or indirectly out of or relating to the Equipment, or the existence, use of failure thereof, unless caused solely by the
willful misconduct or gross negligence of Licensor. The terms and provisions of this Section 7(a) shall survive the expiration or earlier termination of this Agreement. 

(b) NOTWITHSTANDING ANYTHING SET FORTH HEREIN OR IN ANY OTHER AGREEMENT BETWEEN LICENSOR AND LICENSEE TO THE CONTRARY: (i) LICENSOR SHALL
NOT BE LIABLE TO LICENSEE OR ANY OTHER PERSON FOR (AND LICENSEE AND EACH SUCH OTHER PERSON ASSUME ALL RISK OF) LOSS, DAMAGE OR INJURY, WHETHER ACTUAL OR CONSEQUENTIAL TO PERSONAL PROPERTY OF EVERY KIND AND DESCRIPTION, INCLUDING, WITHOUT LIMITATION,
TRADE FIXTURES, EQUIPMENT, INVENTORY, SCIENTIFIC RESEARCH, SCIENTIFIC EXPERIMENTS, LABORATORY ANIMALS, PRODUCT, SPECIMENS, SAMPLES, AND/OR SCIENTIFIC, BUSINESS, ACCOUNTING AND OTHER RECORDS OF EVERY KIND AND DESCRIPTION AND ANY AND ALL INCOME
DERIVED OR DERIVABLE THEREFROM; and (ii) THERE SHALL BE NO PERSONAL RECOURSE TO LICENSOR FOR ANY ACT OR OCCURRENCE IN, ON OR ABOUT THE PREMISES, SHARED CONFERENCE FACILITY OR PROJECT OR ARISING IN ANY WAY UNDER THIS LICENSE AGREEMENT OR ANY
OTHER AGREEMENT BETWEEN LICENSOR AND LICENSEE WITH RESPECT TO THE SUBJECT MATTER HEREOF AND ANY LIABILITY OF LICENSOR HEREUNDER SHALL BE STRICTLY LIMITED SOLELY TO LICENSOR’S INTEREST IN THE PROJECT OR ANY PROCEEDS FROM SALE OR CONDEMNATION
THEREOF AND ANY INSURANCE PROCEEDS PAYABLE IN RESPECT OF LICENSOR’S INTEREST IN THE PROJECT OR IN CONNECTION WITH ANY SUCH LOSS; AND (iii) IN NO EVENT SHALL ANY PERSONAL LIABILITY BE ASSERTED AGAINST LICENSOR OR ANY OF ITS OFFICERS,
DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS IN CONNECTION WITH THIS LICENSE AGREEMENT NOR SHALL ANY RECOURSE BE HAD TO ANY OTHER PROPERTY OR ASSETS OF LICENSOR OR ANY OF LICENSOR’S OFFICERS, DIRECTORS, EMPLOYEES, AGENTS OR CONTRACTORS. 

(c) Licensee acknowledges and agrees that there are no warranties of any kind, whether express or implied, made by Licensor or otherwise with
respect to the Shared Conference Facility or any services (if any) provided in the Shared Conference Facility, and Licensee disclaims any and all such warranties. 

(d) Licensor shall not be in default hereunder unless Licensor fails to perform any of its obligations hereunder within thirty (30) days
after written notice from Licensee specifying such failure, with such extension of time by reason of Force Majeure as may be reasonably necessary; provided, however, that if the nature of Licensor’s obligation arises from an emergency condition
and Licensee provides notice to Licensor (which may be telephonic if followed by written notice on the same day describing the emergency condition in reasonable detail, including without limitation the emergency nature of the condition and
specifying in all capital letters and boldface type that the condition is an emergency and response is required by Licensor pursuant to this Agreement), then Licensor shall respond within a reasonable period after receipt of such notice of the
emergency condition.. Licensee’s sole remedy for any breach or default by Licensor hereunder shall be to terminate this Agreement and Licensee hereby, to the maximum extent possible, knowingly waives the provisions of any law or regulation, now
or hereafter in effect which provides additional or other remedies to Licensee as a result of any breach by Licensor hereunder or under any such law or regulation. 

 215 First/Sage - Page 4 

 
 8. Miscellaneous. 

(a) This Agreement, together with the Lease, constitutes the entire agreement and understanding between the parties, and supersedes all
offers, negotiations and other agreements concerning the subject matter contained herein. Any amendments to this Agreement must be in writing and executed by both parties. 

(b) If any clause or provision of this Agreement is illegal, invalid or unenforceable under present or future laws, then and in that event, it
is the intention of the parties hereto that the remainder of this Agreement shall not be affected thereby. 
 (c) This Agreement shall be
binding on and inure to the benefit of the successors and permitted assigns of the respective parties. 
 (d) All notices or other
communications between the parties shall be in writing and shall be deemed duly given upon delivery or refusal to accept delivery by the addressee thereof if delivered in person, or upon actual receipt if delivered by reputable overnight guaranty
courier, addressed and sent to the parties at their addresses set forth in the Lease (as the same may be revised from time to time in accordance with the terms of the Lease). 

(e) The license granted hereunder is appurtenant to Licensee’s leasehold interest in the Premises and may not be assigned or otherwise
pledged or transferred, directly or indirectly, except in connection with any assignment of the Lease or sublease of the Premises to which Landlord consents or is otherwise permitted under the Lease. In the event of a permitted assignment of the
Lease, this Agreement shall automatically be assigned thereby, and thereupon the assigning Licensee shall have no further rights to use or access the Shared Conference Facility. No assignment or other transfer of the Lease or of this License shall
release Licensee of its obligations hereunder. 
 (f) This Agreement shall be construed, interpreted, governed and enforced pursuant to the
laws of the state in which the Property is located. 
 (g) This Agreement may be executed in multiple counterparts but all counterparts
taken together shall constitute a single document. 
 (h) Time is of the essence of each and every provision of this Agreement. 

(i) The parties to this Agreement hereby acknowledge that each such party and its counsel have participated in the negotiation and preparation
of this Agreement, and this Agreement shall be construed and interpreted without regard to any presumption or other rule requiring construction against the party causing the Agreement to be drafted. 

(j) Licensee acknowledges that its use of the Shared Conference Facility are non-exclusive and will be subject to the use of other tenants and
licensees of the Property. Licensee acknowledges that it will be important for all such users to cooperate with each other to maintain the confidentiality of each party’s documents and operations as well as information a party may hold under
confidential arrangements with third parties. Licensee shall maintain and treat as confidential and secret all information and materials which may intentionally or unintentionally be disclosed to it in connection with such shared occupancy (the
“Confidential Information”). Licensee shall not disclose Confidential Information to any third party and will take appropriate action by instruction, agreement or otherwise with its employees, agents, affiliates, associates,
representatives, contractors and invitees to ensure that security of the Confidential Information is maintained. Notwithstanding the foregoing, Licensee may disclose Confidential Information to the extent that (a) disclosure is compelled by
judicial or administrative process or other requirements of law, or (b) Licensee can show that such Confidential Information (i) was publicly available prior to the date of this Agreement or thereafter became publicly available without

 215 First/Sage - Page 5 

 
 
violation of this Agreement by Licensee or its employees, agents, affiliates, associates, representatives, contractors or invitees, or (ii) became available to Licensee by means other than
its use of or access to the Shared Conference Facility. The provisions of this Section 8(i) shall survive the expiration or earlier termination of this Agreement. 

[Signatures On Next Page] 

 215 First/Sage - Page 6 

 
 IN WITNESS WHEREOF, Licensor and Licensee have caused this
Agreement to be executed by their duly authorized representatives as of the date first above written. 
  

							
	LICENSEE:
	
	 SAGE THERAPEUTICS, INC.,
 a
Delaware corporation

		
	By:	 	  

	Its:	 	  

	
	LICENSOR:
	
	ARE-MA REGION NO. 38, LLC, a Delaware limited liability corporation
		
	By:	 	Alexandria Real Estate Equities, L P.,
		 	a Delaware limited partnership,
		 	managing member
			
		 	By:	 	ARE-QRS Corp., a Maryland
		 		 	corporation, general partner
				
		 		 	By:	 	  

		 		 	Its:	 	  

 215 First/Sage - Page 7 

 
 EXHIBIT 1 TO LICENSE AGREEMENT 

DESCRIPTION OR PLAN OF SHARED CONFERENCE FACILITY 
  

 

 215 First/Sage - Page 8 

 
 EXHIBIT 2 TO LICENSE AGREEMENT 

RULES AND REGULATIONS 
 Rules and
regulations (if any) will be established and implemented by Licensor during the Term. 

 215 First/Sage - Page 1 

 
 EXHIBIT F TO LEASE 

WORK LETTER 
 THIS
WORK LETTER dated December 21, 2011 (this “Work Letter”) is made and entered into by and between ARE-MA REGION NO. 38, LLC, a Delaware limited liability company (“Landlord”), and SAGE THERAPEUTICS,
INC., a Delaware corporation (“Tenant”), and is attached to and made a part of the Lease Agreement dated December 21, 2011 (the “Lease”), by and between Landlord and Tenant. Any initially capitalized terms
used but not defined herein shall have the meanings given them in the Lease. 
 1. General Requirements. 

(a) Tenant’s Authorized Representative. Tenant designates Kimi Iguchi and Kiran Reddy (either such individual acting alone,
“Tenant’s Representative”) as the only persons authorized to act for Tenant pursuant to this Work Letter. Landlord shall not be obligated to respond to or act upon any request, approval, inquiry or other communication
(“Communication”) from or on behalf of Tenant in connection with this Work Letter unless such Communication is in writing from Tenant’s Representative. Tenant may change either Tenant’s Representative at any time upon not
less than 5 business days advance written notice to Landlord. Neither Tenant nor Tenant’s Representative shall be authorized to direct Landlord’s contractors in the performance of Landlord’s Work (as hereinafter defined). 

(b) Landlord’s Authorized Representative. Landlord designates Jeff McComish and Joe Maguire (either such individual acting alone,
“Landlord’s Representative”) as the only persons authorized to act for Landlord pursuant to this Work Letter. Tenant shall not be obligated to respond to or act upon any request, approval, inquiry or other Communication from or
on behalf of Landlord in connection with this Work Letter unless such Communication is in writing from Landlord’s Representative. Landlord may change either Landlord’s Representative at any time upon not less than 5 business days advance
written notice to Tenant. Landlord’s Representative shall be the sole persons authorized to direct Landlord’s contractors in the performance of Landlord’s Work. 

(c) Architects, Consultants and Contractors. Landlord and Tenant hereby acknowledge and agree that: (i) the general contractor and
any subcontractors for the Tenant Improvements shall be selected by Landlord, subject to Tenant’s approval, which approval shall not be unreasonably withheld, conditioned or delayed, and (ii) R.E. Dineen shall be the architect (the
“TI Architect”) for the Tenant Improvements. 
 2. Tenant Improvements. 

(a) Tenant Improvements Defined. As used herein, “Tenant Improvements” shall mean all improvements to the Project of a
fixed and permanent nature as shown on the TI Construction Drawings, as defined in Section 2(c) below. Other than Landlord’s Work (as defined in Section 3(a) below, Landlord shall not have any obligation whatsoever with
respect to the finishing of the Premises for Tenant’s use and occupancy. 
 (b) Tenant’s Space Plans. Landlord and Tenant
acknowledge and agree that that certain plan PL-4A dated October 27, 2011, prepared by the TI Architect attached hereto as Exhibit K (the “Space Plan”), the Basis of Design attached to this Work Letter as Schedule 1
and the general contractor’s proposal attached to this Work Letter as Schedule 2 have been approved by both Landlord and Tenant (“General Contractor Proposal”). Landlord and Tenant further acknowledge and agree that any
changes to the Space Plan constitute a Change Request the cost of which changes shall be paid for by Tenant. Tenant shall be solely responsible for all costs incurred by Landlord to alter the Building (or Landlord’s plans for the Building) as a
result of Tenant’s requested changes. 

 215 First/Sage - Page 2 

 
 (c) Working Drawings. Landlord shall cause the TI Architect to
prepare and deliver to Tenant for review and comment construction plans, specifications and drawings for the Tenant Improvements (“TI Construction Drawings”), which TI Construction Drawings shall be prepared substantially in
accordance with the Space Plan . Tenant shall be solely responsible for ensuring that the TI Construction Drawings reflect Tenant’s requirements for the Tenant Improvements. Tenant shall deliver its written comments on the TI Construction
Drawings to Landlord not later than 10 business days after Tenant’s receipt of the same; provided, however, that Tenant may not disapprove any matter that is consistent with the Space Plan without submitting a Change Request. Landlord and the
TI Architect shall consider all such comments in good faith and shall, within 10 business days after receipt, notify Tenant how Landlord proposes to respond to such comments, but Tenant’s review rights pursuant to the foregoing sentence shall
not delay the design or construction schedule for the Tenant Improvements. Any disputes in connection with such comments shall be resolved in accordance with Section 2(d) hereof. Provided that the design reflected in the TI Construction
Drawings is consistent with the Space Plan, Tenant shall approve the TI Construction Drawings submitted by Landlord, unless Tenant submits a Change Request. Once approved by Tenant, subject to the provisions of Section 4 below, Landlord
shall not materially modify the TI Construction Drawings except as may be reasonably required in connection with the issuance of the TI Permit (as defined in Section 3(b) below). 

(d) Approval and Completion. It is hereby acknowledged by Landlord and Tenant that the TI Construction Drawings must be
completed and approved no later than December 21, 2011, in order for the Landlord’s Work to be Substantially Complete by the Target Commencement Date (as defined in the Lease). Upon any dispute regarding the design of the Tenant
Improvements, which is not settled within 10 business days after notice of such dispute is delivered by one party to the other. Tenant may make the final decision regarding the design of the Tenant Improvements, provided (i) Tenant acts
reasonably and such final decision is either consistent with or a compromise between Landlord’s and Tenant’s positions with respect to such dispute, (ii) that all increases in costs and expenses resulting from any such decision by
Tenant shall be payable by Tenant, and (iii) Tenant’s decision will not affect the base Building, structural components of the Building or any Building systems. Any changes to the TI Construction Drawings following Landlord’s and
Tenant’s approval of same requested by Tenant shall be processed as provided in Section 4 hereof. 
 3. Performance of
Landlord’s Work. 
 (a) Definition of Landlord’s Work. As used herein, “Landlord’s Work” shall
mean the work of constructing the Tenant Improvements. 
 (b) Commencement and Permitting. Landlord shall commence construction of
the Tenant Improvements upon obtaining a building permit (the “TI Permit”) authorizing the construction of the Tenant Improvements consistent with the TI Construction Drawings approved by Tenant. The cost of obtaining the TI Permit
shall be payable by Landlord. Tenant shall assist Landlord in obtaining the TI Permit. If any Governmental Authority having jurisdiction over the construction of Landlord’s Work or any portion thereof shall impose terms or conditions upon the
construction thereof that: (i) are inconsistent with Landlord’s obligations hereunder, (ii) increase the cost of constructing Landlord’s Work, or (iii) will materially delay the construction of Landlord’s Work, Landlord
and Tenant shall reasonably and in good faith seek means by which to mitigate or eliminate any such adverse terms and conditions. 
 (c)
Completion of Landlord’s Work. Landlord shall (i) substantially complete or cause to be substantially completed Landlord’s Work in a good and workmanlike manner, in accordance with the TI Permit subject, in each case, to Minor
Variations and normal “punch list” items of a non-material nature that do not interfere with the use of the Premises, and (ii) obtain a certificate or temporary certificate of occupancy (or an equivalent approval) for the Premises
permitting lawful occupancy of the Premises (but specifically excluding any permits, licenses or other governmental approvals required to be obtained in connection with Tenant’s operations in the Premises)(“Substantial
Completion” or “Substantially Complete”). Upon Substantial Completion of Landlord’s Work, Landlord shall require the TI Architect and the general contractor to execute and deliver, for the benefit of Tenant and
Landlord, a Certificate of 

 215 First/Sage - Page 3 

 
 
Substantial Completion in the form of the American Institute of Architects (“AIA”) document G704. For purposes of this Work Letter, “Minor Variations” shall mean
any modifications reasonably required: (i) to comply with all applicable Legal Requirements and/or to obtain or to comply with any required permit (including the TI Permit); (ii) to comply with any request by Tenant for modifications to
Landlord’s Work; (iii) to comport with good design, engineering, and construction practices that are not material; or (iv) to make reasonable adjustments for field deviations or conditions encountered during the construction of
Landlord’s Work. 
 (d) Selection of Materials. Where more than one type of material or structure is indicated on the TI
Construction Drawings approved by Landlord and Tenant, the option will be selected at Landlord’s sole and absolute subjective discretion. As to all building materials and equipment that Landlord is obligated to supply under this Work Letter,
Landlord shall select the manufacturer thereof in its sole and absolute subjective discretion. 
 (e) Delivery of the Premises. When
Landlord’s Work is Substantially Complete, subject to the remaining terms and provisions of this Section 3(e), Tenant shall accept the Premises. Tenant’s taking possession and acceptance of the Premises shall not constitute a
waiver of: (i) any warranty with respect to workmanship (including installation of equipment) or material (exclusive of equipment provided directly by manufacturers), (ii) any non-compliance of Landlord’s Work with applicable Legal
Requirements, or (iii) any claim that Landlord’s Work was not completed substantially in accordance with the TI Construction Drawings (subject to Minor Variations and such other changes as are permitted hereunder) (collectively, a
“Construction Defect”). Tenant shall have one year after Substantial Completion within which to notify Landlord of any such Construction Defect discovered by Tenant, and Landlord shall use reasonable efforts to remedy or cause the
responsible contractor to remedy any such Construction Defect within 30 days thereafter. Notwithstanding the foregoing, Landlord shall not be in default under the Lease if the applicable contractor, despite Landlord’s reasonable efforts, fails
to remedy such Construction Defect within such 30-day period, in which case Landlord shall have no further obligation with respect to such Construction Defect other than to cooperate, at no cost to Landlord, with Tenant should Tenant elect to pursue
a claim against such contractor. 
 (f) Tenant shall be entitled to receive the benefit of all construction warranties and
manufacturer’s equipment warranties relating to equipment installed in the Premises. If requested by Tenant, Landlord shall attempt to obtain extended warranties from manufacturers and suppliers of such equipment, but the cost of any such
extended warranties shall be borne solely by Tenant. Landlord shall promptly undertake and complete, or cause to be completed, all punch list items. 

(g) Commencement Date Delay. Except as otherwise provided in the Lease, Delivery of the Premises shall occur when Landlord’s Work
has been Substantially Completed, except to the extent that completion of Landlord’s Work shall have been actually delayed by any one or more of the following causes (“Tenant Delay”): 

(i) Tenant’s Representative was not available within 1 business day to give or receive any Communication or to take any
other action required to be taken by Tenant hereunder; 
 (ii) Tenant’s request for Change Requests (as defined in
Section 4(a) below) whether or not any such Change Requests are actually performed; 
 (iii) Construction of any
Change Requests; 
 (iv) Tenant’s request for materials, finishes or installations requiring unusually long lead times;

 (v) Tenant’s delay in reviewing, revising or approving plans and specifications beyond the periods set forth herein;

 215 First/Sage - Page 4 

 
 (vi) Tenant’s delay in providing information
critical to the normal progression of the Project. Tenant shall provide such information as soon as reasonably possible, but in no event longer than one week after receipt of any request for such information from Landlord; 

(vii) Tenant’s delay in making payments to Landlord for Excess TI Costs (as defined in Section 5(b) below); or

 (viii) Any other act or omission by Tenant or any Tenant Party (as defined in the Lease), or persons employed by any of
such persons. 
 If Delivery is delayed for any of the foregoing reasons, then Landlord shall cause the TI Architect to certify the date on which the Tenant
Improvements would have been completed but for such Tenant Delay and such certified date shall be the date of Delivery. 
 4.
Changes. Any changes requested by Tenant to the Tenant Improvements after the delivery and approval by Landlord of the Space Plan shall be requested and instituted in accordance with the provisions of this Section 4 and shall be
subject to the written approval of Landlord and the TI Architect, such approval not to be unreasonably withheld, conditioned or delayed. 

(a) Tenant’s Request For Changes. If Tenant shall request changes to the Tenant Improvements (“Changes”), Tenant
shall request such Changes by notifying Landlord in writing in substantially the same form as the AIA standard change order form (a “Change Request”), which Change Request shall detail the nature and extent of any such Change. Such
Change Request must be signed by Tenant’s Representative. Landlord shall, before proceeding with any Change, respond to Tenant as soon as is reasonably possible with an estimate of: (i) the time it will take, and (ii) the
architectural and engineering fees and costs that will be incurred, to analyze such Change Request (which costs shall be paid by Tenant to the extent actually incurred, whether or not such change is implemented). Landlord shall thereafter submit to
Tenant in writing, within 5 business days of receipt of the Change Request (or such longer period of time as is reasonably required depending on the extent of the Change Request), an analysis of the additional cost or savings involved, including,
without limitation, architectural and engineering costs and the period of time, if any, that the Change will extend the date on which Landlord’s Work will be Substantially Complete. Any such delay in the completion of Landlord’s Work
caused by a Change, including any suspension of Landlord’s Work while any such Change is being evaluated and/or designed, shall be Tenant Delay. 

(b) Implementation of Changes. If Tenant: (i) approves in writing the cost or savings and the estimated extension in the time for
completion of Landlord’s Work, if any, and (ii) deposits with Landlord any Excess TI Costs required pursuant to Section 5(b) below in connection with such Change, Landlord shall cause the approved Change to be instituted.
Notwithstanding any approval or disapproval by Tenant of any estimate of the delay caused by such proposed Change, the TI Architect’s determination of the amount of Tenant Delay in connection with such Change shall be final and binding on
Landlord and Tenant. 
 5. Costs. 

(a) TI Costs. Landlord shall be responsible for all hard and soft costs and expenses for the design and performance of Landlord’s
Work including, without limitation, design, permits and construction costs in connection with the construction of the Tenant Improvements, including, without limitation, the cost of preparing the TI Construction Drawings and the Space Plan, the cost
of rotating one of the exposed HVAC systems to a mutually agreed upon location within the Premises, the cost of constructing the demising corridor shown on the Space Plan and Landlord’s out-of-pocket expenses (collectively, “TI
Costs”). Notwithstanding anything to the contrary contained herein, in no event shall Landlord be required to pay for any furniture, personal property or other non-Building system materials or equipment, including, but not limited to,
Tenant’s voice or data cabling, not incorporated into the Tenant Improvements. 

 215 First/Sage - Page 5 

 
 (b) Excess TI Costs. Notwithstanding anything to the contrary
contained herein, Tenant acknowledges and agrees that Landlord shall have no responsibility for any costs arising from or related to Tenant’s changes to the Space Plan or TI Construction Drawings, Tenant Delays, the cost of Changes and Change
Requests or the cost of all of the items listed on page 3 of the General Contractor Proposal selected by Tenant (collectively, “Excess TI Costs”). Tenant shall deposit with Landlord 50% of the Excess TI Costs as a condition
precedent to Landlord’s obligation to complete the Tenant Improvements and the remaining 50% of the Excess TI Costs upon Substantial Completion of the Tenant Improvements. If Tenant fails to deposit any Excess TI Costs with Landlord, Landlord
shall have all of the rights and remedies set forth in the Lease for nonpayment of Rent (including, but not limited to, the right to interest at the Default Rate and the right to assess a late charge). For purposes of any litigation instituted with
regard to such amounts, those amounts will be deemed Rent under the Lease. 
 6. Tenant Access. 

(a) Tenant’s Access Rights. Landlord hereby agrees to permit Tenant access, at Tenant’s sole risk and expense, to the
Building (i) 30 days prior to the Commencement Date to perform any work (“Tenant’s Work”) required by Tenant other than Landlord’s Work, provided that such Tenant’s Work is coordinated with the TI Architect and
the general contractor, and complies with the Lease and all other reasonable restrictions and conditions Landlord may impose, and (ii) prior to the completion of Landlord’s Work, to inspect and observe work in process; all such access
shall be during normal business hours or at such other times as are reasonably designated by Landlord. Notwithstanding the foregoing, Tenant shall have no right to enter onto the Premises or the Project unless and until Tenant shall deliver to
Landlord evidence reasonably satisfactory to Landlord demonstrating that any insurance reasonably required by Landlord in connection with such pre-commencement access (including, but not limited to, any insurance that Landlord may require pursuant
to the Lease) is in full force and effect. Any entry by Tenant shall comply with all established safety practices of Landlord’s contractor and Landlord until completion of Landlord’s Work and acceptance thereof by Tenant. 

(b) No Interference. Neither Tenant nor any Tenant Party (as defined in the Lease) shall interfere with the performance of
Landlord’s Work, nor with any inspections or issuance of final approvals by applicable Governmental Authorities, and upon any such interference, Landlord shall have the right to exclude Tenant and any Tenant Party from the Premises and the
Project until Substantial Completion of Landlord’s Work. 
 (c) No Acceptance of Premises. The fact that Tenant may, with
Landlord’s consent, enter into the Project prior to the date Landlord’s Work is Substantially Complete for the purpose of performing Tenant’s Work shall not be deemed an acceptance by Tenant of possession of the Premises, but in such
event Tenant shall defend with counsel reasonably acceptable by Landlord, indemnify and hold Landlord harmless from and against any loss of or damage to Tenant’s property, completed work, fixtures, equipment, materials or merchandise, and from
liability for death of, or injury to, any person, caused by the act or omission of Tenant or any Tenant Party. 
 7. Miscellaneous.

 (a) Consents. Whenever consent or approval of either party is required under this Work Letter, that party shall not unreasonably
withhold, condition or delay such consent or approval, unless expressly set forth herein to the contrary. 
 (b) Modification. No
modification, waiver or amendment of this Work Letter or of any of its conditions or provisions shall be binding upon Landlord or Tenant unless in writing signed by Landlord and Tenant. 

 215 First/Sage - Page 6 

 
 Schedule 1 

Basis of Design 
  

			
	

	  	 Sage Therapeutics
  

215 First Street
 Cambridge, Massachusetts

		
	Members of:	  	
		
	American Institute	  	10 December 2011
	of Architects	  	
		
	Boston Society	  	BASIS OF DESIGN – ROOM DATA SHEETS
	of Architects	  	
		  	 Reception

		  	 Office

		  	 Open Office

		  	 Telephone Room

		  	 Closet

		  	 Conference Room

		  	 Large Conference Room

		  	 Break Room

		  	 Copy/Mail/Storage Rooms

		  	 Server Room

 123 North Washington Street, Boston, Massachusetts 02114-2134 tel 617 227 7727 fax 617 227 1870 

 215 First/Sage - Page 7 

 

					
	Sage Therapeutics	  	ROOM DATA SHEET	  	Project No. 11186.11
	215 First Street, Floor 2	  		  	
	Cambridge	  		  	

  

			
	ROOM NAME/NUMBER:	  	Reception
		  	Room No. 201
		
	FUNCTION:	  	Office support space.
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	Existing carpet tile to remain. New Wall Base – 4” high straight vinyl.
		
	 Wall Finish:
	  	Tenant Standard eggshell finish, latex paint.
		
	 Ceiling Height/Finish:
	  	Open to structure above. No finished ceiling.
		
	 Door/Frame/Hardware:
	  	3’-0” x 7’-0” tempered glass entrance door and hardware.
		
	 Glazing:
	  	7’-0” high x 8’-8” long clear, tempered glass wall panels with glazing channels top & bottom and clear silicone joints.
		
	 Casework:
	  	None
		
	EQUIPMENT:	  	None
		
	ENGINEERING SYSTEMS:	  	
		
	 Plumbing:
	  	None
		
	 HVAC:
	  	Base building system sized to adequately maintain a cooling temperature of an inside condition of 75 degrees F, dry bulb at 50% relative humidity; with outside condition of 91 degrees F and 74 degrees F wet bulb during summer and
72 degrees F dry bulb inside at zero degree dry bulb outside during the winter.
	 Electrical:
	  	
		
	 Lighting:
	  	Reuse existing suspended, direct/indirect fluorescent fixtures; industry standard foot-candle level for office environments.
		
	 Power:
	  	Three, duplex convenience power outlets.
		
	 Communications:
	  	Two, single-gang wall box with pull string.

  

			
	R E Dinneen Architects & Planners, Inc.	  	
	123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870	  	10 December 2011

 215 First/Sage - Page 8 

 

					
	Sage Therapeutics	  	ROOM DATA SHEET	  	Project No. 11186.11
	215 First Street, Floor 2	  		  	
	Cambridge	  		  	

  

			
	ROOM NAME/NUMBER:	  	Office
		  	Room Nos. 206, 207, 208, 209, 210, 211, 212, 213, 214, 215 & 216.
		
	FUNCTION:	  	Private office.
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	Existing carpet tile in remain. New Wall Base – 4” high straight vinyl.
		
	 Wall Finish:
	  	Tenant Standard eggshell finish, latex paint.
		
	 Ceiling Height/Finish:
	  	Open to structure above. No finished ceiling.
		
	 Door/Frame/Hardware:
	  	 Tenant Standards: Door – 3’-0” x 7’-0” solid core, clear finished birch face veneers, with full vision panel.

Frame – 3’-0” x 9’-0” with clerestory glazing; hollow metal, alkyd enamel paint finish.

Hardware – Falcon T Series Cylindrical Lockset. A Lever Design with Rose, both in finish 626 “satin chromium plated”. Hinge – Hager full
mortise BB1279 ANSI A8112, 4-1/2” x 4-1/2” steel. Silencer – 1. Floor stop – Hager 243F in finish “satin chrome”.

		
	 Glazing:
	  	2’-0” x8’-0” frameless, clerestory glazing; clear silicone joints: top at 9’-0” AFF: all Offices except Nos. 206 & 211.
		
	 Casework:
	  	None.
		
	EQUIPMENT:	  	One, wall-mounted 4’x4’ dry marker board.
		
	ENGINEERING SYSTEMS:	  	
		
	 Plumbing:
	  	None.
		
	 HVAC:
	  	Base building system sized to adequately maintain a cooling temperature of an inside condition of 75 degrees F, dry bulb at 50% relative humidity; with outside condition of 91 degrees F and 74 degrees F wet bulb during summer and
72 degrees F dry bulb inside at zero degree dry bulb outside during the winter.
	 Electrical:
	  	
		
	 Lighting:
	  	Reuse existing suspended, direct/indirect fluorescent fixtures; industry standard foot-candle level for office environments.
		
	 Power:
	  	One double-duplex and one duplex convenience power outlets.
		
	 Communications:
	  	Single-gang wall box with string.

  

			
	R E Dinneen Architects & Planners, Inc.	  	
	123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870	  	10 December 2011

 215 First/Sage - Page 9 

 

					
	Sage Therapeutics	  	ROOM DATA SHEET	  	Project No. 11186.11
	215 First Street, Floor 2	  		  	
	Cambridge	  		  	

  

			
	ROOM NAME/NUMBER:	  	Open Office
		  	Room No. 217
		
	FUNCTION:	  	General office work environment.
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	Existing carpet tile to remain. New Wall Base – 4” high straight vinyl.
		
	 Wall Finish:
	  	Tenant Standard eggshell finish, latex paint.
		
	 Ceiling Height/Finish:
	  	Open to structure above. No finished ceiling.
		
	 Door/Frame/Hardware:
	  	None.
		
	 Millwork:
	  	None.
		
	EQUIPMENT:	  	None.
		
	ENGINEERING SYSTEMS:	  	
		
	 Plumbing:
	  	None.
		
	 HVAC:
	  	Base building system sized to adequately maintain a cooling temperature of an inside condition of 75 degrees F, dry bulb at 50% relative humidity; with outside condition of 91 degrees F and 74 degrees F wet bulb during summer and
72 degrees F dry bulb inside at zero degree dry bulb outside during the winter.
	 Electrical:
	  	
		
	 Lighting:
	  	Reuse existing suspended, direct/indirect fluorescent fixtures; industry standard foot-candle level for office environments
		
	 Power:
	  	Power feeds to four systems furniture workstation clusters. Fed down columns.
		
	 Communications:
	  	Multiple locations: single-gang wall box with pull string. Fed down columns.

  

			
	R E Dinneen Architects & Planners, Inc.	  	
	123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870	  	10 December 2011

 215 First/Sage - Page 10 

 

					
	Sage Therapeutics	  	ROOM DATA SHEET	  	Project No. 11186.11
	215 First Street, Floor 2	  		  	
	Cambridge	  		  	

  

			
	ROOM NAME/NUMBER:	  	Telephone Room
		  	Rooms Nos. 204, 205
		
	FUNCTION:	  	Private telephone booth within the suite.
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	Existing carpet tile flooring to remain. New Wall Base – 4” high straight vinyl.
		
	 Wall Finish:
	  	Tenant Standard eggshell finish, latex paint.
		
	 Ceiling Height/Finish:
	  	Open to structure above. No finished ceiling.
		
	 Door/Frame/Hardware:
	  	 Tenant Standard: Door – 3’-0” x 7’-0” solid core with clear finished, birch face veneers and with full vision
panel.
 Frame – Hollow metal, alkyd enamel paint finish

Hardware – Falcon T Series Cylindrical Lockset, A Lever Design with Rose, both in finish 626 “satin chromium plated”; Hinge – Stanley full
mortise FBB179 ANSI A8112, 4-1/2” x 4-1/2” steel; Silencers; Floor stop – Rockwood 441 in finish “satin chrome”.

		
	 Millwork:
	  	None.
		
	EQUIPMENT:	  	None
		
	ENGINEERING SYSTEMS:	  	
		
	 Plumbing:
	  	None
		
	 HVAC:
	  	Conditioned air from adjacent Reception Area.
		
	 Electrical:
	  	
		
	 Lighting:
	  	Wall mounted fluorescent light fixture.
		
	 Power:
	  	Duplex convenience power outlet.
		
	 Communications:
	  	Single-gang wall box with pull string.

  

			
	R E Dinneen Architects & Planners, Inc.	  	
	123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870	  	10 December 2011

 215 First/Sage - Page 11 

 

					
	Sage Therapeutics	  	ROOM DATA SHEET	  	Project No. 11186.11
	215 First Street, Floor 2	  		  	
	Cambridge	  		  	

  

			
	ROOM NAME/NUMBER:	  	Closet
		  	Room No. 202
		
	FUNCTION:	  	Coat storage space within the suite.
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	Existing carpet tile to remain. New Wall Base – 4” high straight vinyl.
		
	 Wall Finish:
	  	Tenant Standard eggshell finish, latex paint.
		
	 Ceiling Height/Finish:
	  	Open to structure above. No finished ceiling.
		
	 Door/Frame/Hardware:
	  	 Tenant Standards: Door – Pair 3 -0” x 7’-0” solid core with birch face veneers for clear finish.

Frame – Hollow metal, alkyd enamel paint finish
 Hardware
– Falcon T Series dummy pulls, A Lever Design with Rose, both in finish 626 “satin chromium plated”; Hinge – Stanley full mortise FBB179 ANSI A8112, 4-1/2” x 4-1/2” steel; Silencers; Floor stop – Rockwood 441 in
finish “satin chrome”

		
	 Millwork:
	  	Coat rod with plastic laminate finished hat shelf
		
	EQUIPMENT:	  	None
		
	ENGINEERING SYSTEMS:	  	
		
	 Plumbing:
	  	None
		
	 HVAC:
	  	Conditioned air from adjacent Reception Area.
		
	 Electrical:
	  	
		
	 Lighting:
	  	Wall mounted fluorescent light fixture with jamb activated switching.
		
	 Power:
	  	None.
		
	 Communications:
	  	None.

  

			
	R E Dinneen Architects & Planners, Inc.	  	
	123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870	  	10 December 2011

 215 First/Sage - Page 12 

 

					
	Sage Therapeutics	  	ROOM DATA SHEET	  	Project No. 11186.11
	215 First Street, Floor 2	  		  	
	Cambridge	  		  	

  

			
	ROOM NAME/NUMBER:	  	Conference Room
		  	Room No. 203
		
	FUNCTION:	  	Office support area used for meetings.
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	Exiting carpet tile flooring to remain. New Wall Base – 4” high straight vinyl.
		
	 Wall Finish:
	  	Tenant Standard eggshell finish, latex paint.
		
	 Ceiling Height/Finish:
	  	Open to structure above. No finished ceiling.
		
	 Door/Frame/Hardware:
	  	3’-0” x 7’-0” frameless, clear tempered glass door with hardware.
		
	 Glazing:
	  	7’-0” high x 5’-0” long clear, tempered glass wall panels with glazing channels top & bottom and with clear silicone joints.
		
	 Millwork:
	  	None.
		
	EQUIPMENT:	  	One, wall-mounted 4’x4’ dry marker board.
		
	ENGINEERING SYSTEMS:	  	
		
	 Plumbing:
	  	None.
		
	 HVAC:
	  	Base building system sized to adequately maintain a cooling temperature of an inside condition of 75 degrees F, dry bulb at 50% relative humidity; with outside condition of 91 degrees F and 74 degrees F wet bulb during summer and
72 degrees F dry bulb inside at zero degree dry bulb outside during the winter.
		
	 Electrical:
	  	
		
	 Lighting:
	  	Reuse existing suspended, direct/indirect fluorescent fixtures; industry standard foot-candle level for office environments
		
	 Power:
	  	Three duplex convenience power outlets.
		
	 Communications:
	  	One, single-gang wall box with pull string.

  

			
	R E Dinneen Architects & Planners, Inc.	  	
	123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870	  	10 December 2011

 215 First/Sage - Page 13 

 

					
	Sage Therapeutics	  	ROOM DATA SHEET	  	Project No. 11186.11
	215 First Street, Floor 2	  		  	
	Cambridge	  		  	

  

			
	ROOM NAME/NUMBER:	  	Large Conference Room
		  	Room No. 219
		
	FUNCTION:	  	Office support area used for meetings.
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	Existing carpet tile flooring to remain. New Wall Base – 4” high straight vinyl.
		
	 Wall Finish:
	  	Tenant Standard eggshell finish, latex paint.
		
	 Ceiling Height/Finish:
	  	Open to structure above. No finished ceiling.
		
	 Door/Frame/Hardware:
	  	 Tenant Standards: Door – 3’-0” x 7”-0 solid core with clear finished, birch face veneers and with full glass lite.

Frame – Hollow metal, alkyd enamel paint finish. 9’-0” high with clerestory glazing.

Hardware – Falcon T Series Cylindrical Lockset, A Lever Design with Rose, both in finish 626 “satin chromium plated”; Hinge – Stanley full
mortise FBB179 ANSI A8112, 4-1/2” x 4-1/2” steel; Silencers; Floor stop – Rockwood 441 in finish “satin chrome”.

		
	 Glazing:
	  	2’-0”x14’-0” frameless, clerestory glazing; clear silicone joints; top at 9’-0” AFF.
		
	 Millwork:
	  	None.
		
	EQUIPMENT:	  	Modernfold Acousti-Seal 933 movable wall system; 9’-0” high x 20’ -0” long. One, 4’x8’ wall-mounted dry marker board.
		
	ENGINEERING SYSTEMS:	  	
		
	 Plumbing:
	  	None
		
	 HVAC:
	  	Base building system sized to adequately maintain a cooling temperature of an inside condition of 75 degrees F, dry bulb at 50% relative humidity; with outside condition of 91 degrees F and 74 degrees F wet bulb during summer and
72 degrees F dry bulb inside at zero degree dry bulb outside during the winter.
		
	 Electrical:
	  	
		
	 Lighting:
	  	Reuse existing suspended, direct/indirect fluorescent fixtures; industry standard foot-candle level for office environments.
		
	 Power:
	  	Four duplex convenience power outlets. Add Alternate; Provide floor box under table with powered data A-V capabilities Provide 1” conduit from floor box to adjacent partition; terminate conduit 12” AFF
		
	 Communications:
	  	Two, single-gang wall box with pull string.

  

			
	R E Dinneen Architects & Planners, Inc.	  	
	123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870	  	10 December 2011

 215 First/Sage - Page 14 

 

					
	Sage Therapeutics	  	ROOM DATA SHEET	  	Project No. 11186.11
	215 First Street, Floor 2	  		  	
	Cambridge	  		  	

  

			
	ROOM NAME/NUMBER:	  	Break Room
		  	Room No. 218
		
	FUNCTION:	  	Support space providing access to beverage service, sink and consumables storage.
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	Vinyl plank flooring at serving area: existing carpet tiles in eating area. New Wall Base – 4” high coved vinyl.
		
	 Wall Finish:
	  	Tenant Standard eggshell finish, latex paint.
		
	 Ceiling Height/Finish:
	  	Open to structure above. No finished ceiling.
		
	 Door/Frame/Hardware:
	  	None.
		
	 Glazing:
	  	None.
		
	 Millwork:
	  	P. Lam. finished base cabinets, wall cabinets and countertops with full height splash. P. Lam. finished island with base cabinets and countertop.
		
	EQUIPMENT:	  	Standard duty stainless steel refrigerator and dishwasher. Utilities provided to support Tenant furnished microwave and coffeemaker.
		
	ENGINEERING SYSTEMS:	  	
		
	 Plumbing:
	  	Stainless steel, ADA accessible sink with hot/cold water faucet; water for coffeemaker; dishwasher with domestic hot water heater.
		
	 HVAC:
	  	Base building system sized to adequately maintain a cooling temperature of an inside condition of 75 degrees F. dry bulb at 50% relative humidity; with outside condition of 91 degrees F and 74 degrees F wet bulb during summer and
72 degrees F dry bulb inside at zero degree dry bulb outside during the winter
	 Electrical:
	  	
		
	 Lighting:
	  	Reuse existing suspended, direct/indirect fluorescent fixtures; industry standard foot-candle level for office environments.
		
	 Power:
	  	Three duplex convenience power outlets, one GFI convenience power outlet.
		
	 Communications:
	  	None.

  

			
	R E Dinneen Architects & Planners, Inc.	  	
	123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870	  	10 December 2011

 215 First/Sage - Page 15 

 

					
	Sage Therapeutics	  	ROOM DATA SHEET	  	Project No. 11186.11
	215 First Street, Floor 2	  		  	
	Cambridge	  		  	

  

			
	ROOM NAME/NUMBER:	  	Copy/Mail/Storage Room
		  	Room No. 220.221
		
	FUNCTION:	  	Mail room and copier location
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	Existing carpet tile flooring to remain. New Wall Base – 4” high straight vinyl.
		
	 Wall Finish:
	  	Tenant Standard eggshell finish, latex paint.
		
	 Ceiling Height/Finish:
	  	Open to structure above. No finished ceiling.
		
	 Door/Frame/Hardware:
	  	None.
		
	 Millwork:
	  	P. Lam. finished base cabinets with countertop; Two high, P. Lam. finished, adjustable shelving oil standards and brackets.
		
	EQUIPMENT:	  	Postage scale, postage meter, copier, all by Tenant.
		
	ENGINEERING SYSTEMS:	  	
		
	 Plumbing:
	  	None.
		
	 HVAC:
	  	Base building system sized to adequately maintain a cooling temperature of an inside condition of 75 degrees F, dry bulb at 50% relative humidity; with outside condition of 91 degrees F and 74 degrees F wet bulb during summer and
72 degrees F dry bulb inside at zero degree dry bulb outside during the winter.
	 Electrical:
	  	
		
	 Lighting:
	  	Reuse existing suspended, direct/indirect fluorescent fixtures; industry standard foot-candle level for office environments.
		
	 Power:
	  	Six, duplex convenience power outlets.
		
	 Communications:
	  	Three, single-gang wall box with pull string.

  

			
	R E Dinneen Architects & Planners, Inc.	  	
	123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870	  	10 December 2011

 215 First/Sage - Page 16 

 

					
	Sage Therapeutics	  	ROOM DATA SHEET	  	Project No. 11186.11
	215 First Street, Floor 2	  		  
	Cambridge	  		  	

  

			
	ROOM NAME/NUMBER:	  	Server Room
		  	Room No. 222
		
	FUNCTION:	  	Data communications support environment.
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	12”xl2”x1/8” vinyl composition tile. Base – 4” high vinyl.
		
	 Wall Finish:
	  	Eggshell finish latex paint. Provide painted, plywood backboard. 4’-0” high by full width of room.
		
	 Ceiling Height/Finish:
	  	Open to structure above. No finished ceiling.
		
	 Door/Frame/Hardware:
	  	 Door – 3’-0” x 7’-0” solid core with natural finished birch face veneers and with air transfer grille.

Frame – Hollow metal, alkyd enamel paint finish.
 Hardware
– Uni-Cam push-button lockset; finish 626 “satin chromium plated”. Hinge – Hager full mortise BB1279 ANSI A8112, 4-1/2” x 4-1/2” steel. Closer; silencers. Floor stop – Hager 243F in finish “satin
chrome”.

		
	 Casework:
	  	None.
		
	EQUIPMENT:	  	Two 24”x42” Data Racks and One 24”x24” Telco Rack, furnished and installed by Tenant.
		
	ENGINEERING SYSTEMS:	  	
		
	 Plumbing:
	  	None.
		
	 HVAC:
	  	1.5 ton, ductless, split air conditioning system. Add Alternate Exhaust fan (500 CFM) powered thru Tenant’s UPS.
	 Electrical:
	  	
		
	 Lighting:
	  	1’-0” x 4’-0” suspended, direct/indirect fluorescent fixtures.
		
	 Power:
	  	 1 – 120v 20 amp. dedicated outlet, NEMA 5-20R.

Add Alternate, add to above – 2 – 208v 30 amp outlets. NEMA 1.6-30R

		
	 Communications:
	  	Fire alarm module for release of access system

  

			
	R E Dinneen Architects & Planners, Inc.	  	
	123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870	  	10 December 2010

 215 First/Sage - Page 17 

 
 Schedule 2 

General Contractor Proposal 
  

			
	

	  	PROPOSAL
		
	180 Main Street, North Easton, MA 02356	  	
	 T 508.230.2600            F 508.238.0557

www.verteccorp.com
	  	DATE:             12/13/2011

  

					
	PROJECT:	  	 Sage Therapeutics

Interior fit-up

			
	 TRADE
	  	 SCOPE
	  	 Price

		
	GENERAL CONDITIONS	  	
		  	On site management	  	
		  	Office management	  	
		  	Temporary protection	  	
		  	Permits	  	
		  	Disposal & cleanup	  	
	Costs based on Sage Therapeutics, LEI and back area being done simultaneously	  	
	DEMOLITION	  	
		  	Interior demolition	  	
	FINISH CARPENTRY WORK	  	
		  	Counter tops and high table/bar island	  	
		  	Base cabinets	  	
		  	Wall cabinets	  	
		  	Marker boards	  	
		  	Install doors	  	
		  	Install and trim out transom window	  	
	ROOFING	  	
		  	Patch roof as required for a/c lines to computer room	  	
	DOORS/FRAMES/HARDWARE	  	
		  	Wood full-lite doors with sidelights in HM frames	  	
		  	Wood solid core doors	  	
	GLASS & GLAZING	  	
		  	Interior aluminum glazing system and door at entrance	  	
		  	Glazing at doors and borrowed lite office windows	  	
	DRYWALL	  	
		  	New metal stud partitions and insulation - level 4 finish	  	
	FLOORING	  	 	  	
		  	Vinyl plank at serving area in lunch room	  	
		  	Remove, alter and reinstall existing carpet tiles	  	
		  	Resilient base at GWB walls	  	

 215 First/Sage - Page 18 

 
  

					
	PAINTING	  	                     
		  	Includes painting of new partitions, doors frames.	  	
	SPECIALTIES	  	
		  	White boards (16) and accordian wall	  	
	APPLIANCES	  	
		  	Standard duty stainless steel refrigerator and dishwasher	  	
	FIRE PROTECTION	  	
		  	Tie into existing system and add heads as required.	  	
	PLUMBING	  	
		  	Sink in lunch area	  	
		  	Includes supply and waste to closest stack	  	
	HVAC	  	
		  	Reconfigure existing system to accommodate new spaces	  	
		  	Relocate and rotate one existing AHU	  	
	ELECTRICAL	  	
		  	Relocation and modifications to existing lighting	  	
		  	Controls for new lighting	  	
		  	Power distribution for alterations	  	
		  	Conduits and pull strings for tel/data	  	
		  	New code lighting for eggress	  	
		  	All circuits to be tied in and originate from the existg elec panel	  	
	 	  	SUBTOTAL	  	
		  	DESIGN & ENGINEERING COSTS	  	
		  	OVERHEAD & PROFIT	  	
		  	PROJECT CONTINGENCY	  	
		  	TOTAL	  	

 215 First/Sage - Page 19 

 
  
 

 
 Sage Therapeutics 

12/13/11 
 Alternates 

 

													
	 Alt #
	 	  	 Location/room
	  	 Description
	  	 Type
	  	Amount	 
	 	1	  	  	All areas	  	 Furnish and install Tel/Data wiring
	  	Add	  	$	16,913	  
	 	2	  	  	Conf rm 220	  	 Add electric operated projection screen to conference room
	  	Add	  	$	4,400	  
	 	3	  	  	All areas	  	 Furnish clear glass marker boards in lieu of white standard-inc offices - 16ea
	  	Add	  	$	24,024	  
	 	4	  	  	Existing	  	 Relocate existing air handling unit Cost for each (1 in base once)
	  	Add	  	$	6,750	  
	 	5	  	  	Conf rm 220	  	 Add 3’x9’ butt glazed area in front of kitchen
	  	Add	  	$	4,811	  
	 	6	  	  	Offices & conf 220	  	 Add full glass doors to offices, kitchen and conference rooms - 13ea
	  	Add	  	$	33,605	  
	 	7	  	  	Per unit	  	 Add for individually controlled electric baseboard heat in offices Per 4’ unit
	  	Add/ea	  	$	1,161	  
	 	8	  	  	Reception 201	  	 Add for card access system to Sage space entrance
	  	Add	  	$	5,000	  
	 	9	  	  	Conf rm 220	  	 Add for marker board at both sides of accordian wall
	  	Add	  	$	3,500	  
	 	10	  	  	Conf rm 220	  	 Add floor box w/power/data/AV w/1” conduit
	  	Add	  	$	3,210	  
	 	11	  	  	Break rm 218	  	 Add 12’ of under cabinet fluorescent lights.
	  	Add	  	$	660	  
	 	12	  	  	Closet 202	  	 Add wall mounted fluorescent light fixture w/ jamb switch
	  	Add	  	$	605	  
	 	13	  	  	Copy 219	  	 Add 6 duplex receptacles fed from 3-20 amp circuits
	  	Add	  	$	1,485	  
	 	14	  	  	Server 222	  	 Add exhaust fan
	  	Add	  	$	1,320	  
	 	15	  	  	Server 222	  	 Add 1-120V, 20 amp 2-208V, 20 amp circuits w/outlets
	  	Add	  	$	968	  
	 	16	  	  	Server 222	  	 Add fire alarm module for release of access system
	  	Add	  	$	1,375	  
	 	17	  	  	All areas	  	 Add turnclocks to automatically shut down baseboard heaters
	  	Add	  	$	1,615	  

 215 First/Sage - Page 1 

 
 EXHIBIT G TO LEASE 

ACKNOWLEDGMENT OF COMMENCEMENT DATE 

This ACKNOWLEDGMENT OF COMMENCEMENT DATE is made this      day of
            ,     , between ARE-MA REGION NO. 38, LLC, a Delaware limited liability company (“Landlord”), and SAGE THERAPEUTICS, INC., a
Delaware corporation (“Tenant”), and is attached to and made a part of the Lease dated             ,    (the “Lease”), by and between
Landlord and Tenant. Any initially capitalized terms used but not defined herein shall have the meanings given them in the Lease. 

Landlord and Tenant hereby acknowledge and agree, for all purposes of the Lease, that the Commencement Date of the Base Term of the Lease is
            ,     and the termination date of the Base Term of the Lease shall be midnight on             ,
    . In case of a conflict between this Acknowledgment of Commencement Date and the Lease, this Acknowledgment of Commencement Date shall control for all purposes. 

IN WITNESS WHEREOF, Landlord and Tenant have executed this ACKNOWLEDGMENT OF COMMENCEMENT DATE to be effective on the date first above
written. 
  

							
	TENANT:
	
	SAGE THERAPEUTICS, INC.,
a Delaware corporation
		
	By:	 	  

	Its:	 	  

	
	LANDLORD:
	
	ARE-MA REGION NO. 38, LLC, a Delaware limited liability corporation
		
	By:	 	Alexandria Real Estate Equities, L.P.,
a Delaware limited partnership, managing member
			
		 	By:	 	ARE-QRS Corp., a Maryland corporation, general partner
				
		 		 	By:	 	  

		 		 	Its:	 	  

 215 First/Sage - Page 1 

 
 EXHIBIT H TO LEASE 

TENANT’S PERSONAL PROPERTY 

None. 

			
	Rules and Regulations	  	215 First/Sage - Page 1

  

EXHIBIT I TO LEASE 

Rules and Regulations 

1. The sidewalk, entries, and driveways of the Project shall not be obstructed by Tenant, or any Tenant Party, or used by them for any purpose
other than ingress and egress to and from the Premises. 
 2. Tenant shall not place any objects, including antennas, outdoor furniture,
etc., in the parking areas, landscaped areas or other areas outside of its Premises, or on the roof of the Project. 
 3. Except for animals
assisting the disabled, no animals shall be allowed in the offices, halls, or corridors in the Project. 
 4. Tenant shall not disturb the
occupants of the Project or adjoining buildings by the use of any radio or musical instrument or by the making of loud or improper noises. 

5. If Tenant desires telegraphic, telephonic or other electric connections in the Premises, Landlord or its agent will direct the electrician
as to where and how the wires may be introduced; and, without such direction, no boring or cutting of wires will be permitted Any such installation or connection shall be made at Tenant’s expense. 

6. Tenant shall not install or operate any steam or gas engine or boiler, or other mechanical apparatus in the Premises, except as
specifically approved in the Lease. The use of oil, gas or inflammable liquids for heating, lighting or any other purpose is expressly prohibited. Explosives or other articles deemed extra hazardous shall not be brought into the Project. 

7. Parking any type of recreational vehicles is specifically prohibited on or about the Project. Except for the overnight parking of operative
vehicles, no vehicle of any type shall be stored in the parking areas at any time. In the event that a vehicle is disabled, it shall be removed within 48 hours. There shall be no “For Sale” or other advertising signs on or about any parked
vehicle. All vehicles shall be parked in the designated parking areas in conformity with all signs and other markings. All parking will be open parking, and no reserved parking, numbering or lettering of individual spaces will be permitted except as
specified by Landlord. 
 8. Tenant shall maintain the Premises free from rodents, insects and other pests. 

9. Landlord reserves the right to exclude or expel from the Project any person who, in the judgment of Landlord, is intoxicated or under the
influence of liquor or drugs or who shall in any manner do any act in violation of the Rules and Regulations of the Project. 
 10. Tenant
shall not cause any unnecessary labor by reason of Tenant’s carelessness or indifference in the preservation of good order and cleanliness. Landlord shall not be responsible to Tenant for any loss of property on the Premises, however occurring,
or for any damage done to the effects of Tenant by the janitors or any other employee or person. 
 11. Tenant shall give Landlord prompt
notice of any defects in the water, lawn sprinkler, sewage, gas pipes, electrical lights and fixtures, heating apparatus, or any other service equipment affecting the Premises. 

12. Tenant shall not permit storage outside the Premises, including without limitation, outside storage of trucks and other vehicles, or
dumping of waste or refuse or permit any harmful materials to be placed in any drainage system or sanitary system in or about the Premises. 

			
	Rules and Regulations	  	215 First/Sage - Page 2

  

13. All moveable trash receptacles provided by the trash disposal firm for the Premises must be kept in the trash enclosure areas, if any,
provided for that purpose. 
 14. No auction, public or private, will be permitted on the Premises or the Project. 

15. No awnings shall be placed over the windows in the Premises except with the prior written consent of Landlord. 

16. The Premises shall not be used for lodging, sleeping or cooking (except that Tenant may use microwave ovens, toasters and coffee makers in
the Premises for the benefit of Tenant’s employees and contractors in an area designated for such items, but only if the use thereof is at all times supervised by the individual using the same) or for any immoral or illegal purposes or for any
purpose other than that specified in the Lease. No gaming devices shall be operated in the Premises. 
 17. Tenant shall ascertain from
Landlord the maximum amount of electrical current which can safely be used in the Premises, taking into account the capacity of the electrical wiring in the Project and the Premises and the needs of other tenants, and shall not use more than such
safe capacity. Landlord’s consent to the installation of electric equipment shall not relieve Tenant from the obligation not to use more electricity than such safe capacity. 

18. Tenant assumes full responsibility for protecting the Premises from theft, robbery and pilferage. 

19. Tenant shall not install or operate on the Premises any machinery or mechanical devices of a nature not directly related to Tenant’s
ordinary use of the Premises and shall keep all such machinery free of vibration, noise and air waves which may be transmitted beyond the Premises. 

 215 First/Sage - Page 1 

 
 EXHIBIT J TO LEASE 

NOTIFICATION OF THE PRESENCE OF ASBESTOS CONTAINING MATERIALS 

This notification provides certain information about asbestos within or about the Premises at 215 First Street, Cambridge, MA (“Building”).

 Historically, asbestos was commonly used in building products used in the construction of buildings across the country. Asbestos-containing building
products were used because they are fire-resistant and provide good noise and temperature insulation. Because of their prevalence, asbestos-containing materials, or ACMs, are still sometimes found in buildings today. 

No ACMs were identified in an asbestos survey of the building conducted in 2007. However, to avoid damage, several materials were not sampled and are presumed
asbestos-containing materials or PACMs as listed in the following table: 
  

			
	 Material Description
	  	 Material Location

	Ceramic tile adhesive and grout	  	Throughout restrooms; ground floor hallways; first floor lobby and hallways
	Built-up roofing beneath rubber	  	Throughout roof
	Flashing cement	  	Roof
	Flex connectors on HVAC units	  	Roof

 The PACMs described above were observed to be in good condition and may be managed in place. Because ACMs may be present
within or about the Building, we have hired an independent environmental consulting firm to prepare an operations and maintenance program (“O&M Program”). The O&M Program is designed to minimize the potential of any harmful
asbestos exposure to any person within or about the Building. The O&M Program includes a description of work methods to be taken in order to maintain any ACMs or PACMs within or about the Building in good condition and to prevent any significant
disturbance of such ACMs or PACMs. Appropriate personnel receive regular periodic training on how to properly administer the O&M Program. 
 The O&M
Program describes the risks associated with asbestos exposure and how to prevent such exposure through appropriate work practices. ACMs and PACMs generally are not thought to be a threat to human health unless asbestos fibers are released into the
air and inhaled. This does not typically occur unless (1) the ACMs are in a deteriorating condition, or (2) the ACMs have been significantly disturbed (such as through abrasive cleaning, or maintenance or renovation activities). If
inhaled, asbestos fibers can accumulate in the lungs and, as exposure increases, the risk of disease (such as asbestosis or cancer) increases. However, measures to minimize exposure, and consequently minimize the accumulation of asbestos fibers,
reduce the risks of adverse health effects. 
 The O&M Program describes a number of activities that should be avoided in order to prevent a release of
asbestos fibers. In particular, you should be aware that some of the activities which may present a health risk include moving, drilling, boring, or otherwise disturbing ACMs. Consequently, such activities should not be attempted by any person not
qualified to handle ACMs. 
 The O&M Program is available for review during regular business hours at Landlord’s office located at 700 Technology
Square, Suite 302, Cambridge, MA 02139. 

 215 First/Sage - Page 1 

 
 EXHIBIT K TO LEASE 

SPACE PLAN 
  

 

 FIRST AMENDMENT TO LEASE 

THIS FIRST AMENDMENT TO LEASE (this “First Amendment”) is made as of October 26, 2012, by and between ARE-MA REGION
NO. 38, LLC, a Delaware limited liability company (“Landlord”), and SAGE THERAPEUTICS, INC., a Delaware corporation (“Tenant”). 

RECITALS 
 A.
Landlord and Tenant are now parties to that certain Lease Agreement dated as of December 21, 2011 (the “Lease”). Pursuant to the Lease, Tenant leases certain premises consisting of approximately 5,900 rentable square feet of
space (“Original Premises”) in a building located at 215 First Street, Cambridge, Massachusetts (“Building”). The Original Premises are more particularly described in the Lease. Capitalized terms used herein without
definition shall have the meanings defined for such terms in the Lease. 
 B. Landlord and Tenant desire, subject to the terms and
conditions set forth below, to amend the Lease to, among other things, expand the size of the Original Premises by adding approximately 600 rentable square feet of space on the second floor of the Building. 

NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by this reference, the mutual promises and
conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 

 

	1.	Expansion Premises. In addition to the Original Premises, commencing on the Expansion Premises Commencement Date (as defined below), Landlord leases to Tenant, and Tenant leases from Landlord, that certain
portion of the second floor of the Building, containing approximately 600 rentable square feet, as shown on Exhibit A attached hereto (the “Expansion Premises”). 

 

	2.	Delivery. Landlord shall use reasonable efforts to deliver the Expansion Premises to Tenant on or before the Target Expansion Premises Commencement Date with Landlord’s Work Substantially Completed
(“Delivery” or “Deliver”). If Landlord fails to timely Deliver the Expansion Premises, Landlord shall not be liable to Tenant for any loss or damage resulting therefrom, and the Lease with respect to the Expansion
Premises shall not be void or voidable. As used herein, the terms “Landlord’s Work” and “Substantially Completed” shall have the meanings set forth for such terms in the work letter attached to this First
Amendment as Exhibit B (“Expansion Premises Work Letter”). 

 The “Expansion Premises
Commencement Date” shall be the date that Landlord delivers the Expansion Premises to Tenant. The “Target Expansion Premises Commencement Date” shall be January 1, 2013. Upon request of Landlord, Tenant shall execute
and deliver a written acknowledgment of the Expansion Premises Commencement Date and the expiration date of the Lease in a form substantially similar to the form of the “Acknowledgement of Commencement Date” attached to the Lease as
Exhibit G; provided, however. Tenant’s failure to execute and deliver such acknowledgment shall not affect Landlord’s rights hereunder. 

Except as set forth in the Expansion Premises Work Letter: (i) Tenant shall accept the Expansion Premises in their condition as of the
Expansion Premises Commencement Date, subject to all applicable Legal Requirements; (ii) Landlord shall have no obligation for any defects in the Expansion Premises; and (iii) Tenant’s taking possession of the Expansion Premises shall
be conclusive evidence that Tenant accepts the Expansion Premises and that the Expansion Premises were in good condition at the time possession was taken. The Expansion Premises shall be delivered to Tenant without any furniture. 

  
 1 

 Tenant agrees and acknowledges that neither Landlord nor any agent of Landlord has made any
representation or warranty with respect to the condition of all or any portion of the Expansion Premises, and/or the suitability of the Expansion Premises for the conduct of Tenant’s business, and Tenant waives any implied warranty that the
Expansion Premises are suitable for the Permitted Use. 
  

	3.	Definition of Premises. Commencing on the Expansion Premises Commencement Date, the defined term “Premises” on Page 1 of the Lease is deleted in its entirety and replaced with the
following: 

 “Premises: That portion of the second floor of the Building (as defined below)
containing approximately 6,500 rentable square feet, consisting of (i) approximately 5,900 rentable square feet (“Original Premises”), and (ii) approximately 600 rentable square feet (“Expansion
Premises”), all as determined by Landlord, as shown on Exhibit A.” 
 Exhibit A attached to the Lease is hereby
amended to include Exhibit A attached to this First Amendment. 
  

	4.	Base Rent. Tenant shall continue to pay Base Rent for the Original Premises as provided for in the Lease through the Expiration Date (as defined in Section 6 below). Commencing on the Expansion
Premises Commencement Date and continuing through the Expiration Date, Tenant shall pay Base Rent per square foot of the Expansion Premises in an amount equal to the per square foot amount of Base Rent payable for the Original Premises, as adjusted
pursuant to the schedule set forth on the first page of the Lease. 

  

	5.	Tenant’s Share. Commencing on the Expansion Premises Commencement Date, the defined term “Tenant’s Share” on page 1 of the Lease is deleted in its entirety and replaced with the
following: 

 “Tenant’s Share: 1.77%” 

 

	6.	Base Term. Commencing on the Expansion Premises Commencement Date, the defined term “Base Term” on page 1 of the Lease is deleted in its entirety and replaced with the following:

 “Base Term: Beginning (i) with respect to the Original Premises, on the Commencement Date,
and (ii) with respect to the Expansion Premises, on the Expansion Premises Commencement Date and, with respect to the entire Premises ending on February 28, 2017 (“Expiration Date”).” 

 

	7.	Rentable Area of Premises. Commencing on the Expansion Premises Commencement Date, the defined term “Rentable Area of Premises” on page 1 of the Lease is deleted in its entirety and
replaced with the following: 

 “Rentable Area: Approximately 6,500 square feet” 

 

	8.	Parking. Commencing on the Expansion Premises Commencement Date, Tenant’s license for parking at the surface parking lots at the Project or at the “Brown Lot” at 100 Binney Street,
Cambridge, Massachusetts, pursuant to Section 8 of the Lease, shall be increased by 1 parking space so that Tenant shall have a license to use a total of 7 parking spaces. Commencing on the Expansion Premises Commencement Date, Tenant
shall pay, as Additional Rent, $220 per month for such additional parking space. 

  
 2 

	9.	Tenant’s Notice Address. Commencing on the date of this First Amendment, the defined term “Tenant’s Notice Address” on page 2 of the Lease is deleted in its entirety and replaced
with the following: 

 “Tenant’s Notice Address: 

215 First, Suite 230 

Cambridge, MA 02142 

Attn: Lease Administrator” 
  

	10.	Brokers. Landlord and Tenant each represents and warrants that it has not dealt with any broker, agent or other person (collectively, “Broker”) in connection with the transaction reflected
in this First Amendment and that no Broker brought about this transaction, other than Richards, Barry Joyce & Partners and Cushman & Wakefield. Landlord and Tenant each hereby agrees to indemnify and hold the other harmless from
and against any claims by any Broker claiming a commission or other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this leasing transaction. 

 

	11.	Miscellaneous. 

 a. This First Amendment is the entire agreement between
the parties with respect to the subject matter hereof and supersedes all prior and contemporaneous oral and written agreements and discussions. This First Amendment may be amended only by an agreement in writing, signed by the parties hereto. 

b. This First Amendment is binding upon and shall inure to the benefit of the parties hereto, their respective agents, employees,
representatives, officers, directors, divisions, subsidiaries, affiliates, assigns, heirs, successors in interest and shareholders. 

c. This First Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which when
taken together shall constitute one and the same instrument. The signature page of any counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided such signature page is attached to any other
counterpart identical thereto except having additional signature pages executed by other parties to this First Amendment attached thereto. 

d. Except as amended and/or modified by this First Amendment, the Lease is hereby ratified and confirmed and all other terms of the
Lease shall remain in full force and effect, unaltered and unchanged by this First Amendment. In the event of any conflict between the provisions of this First Amendment and the provisions of the Lease, the provisions of this First Amendment shall
prevail. Whether or not specifically amended by this First Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of this First Amendment. 

  
 3 

 IN WITNESS WHEREOF, the parties hereto have executed this First Amendment as of the day
and year first above written. 
  

							
	TENANT:
	
	 SAGE THERAPEUTICS, INC.,
 a
Delaware corporation

		
	By:	 	

	Its:	 	 
	
	LANDLORD:
	
	 ARE-MA REGION NO. 38, LLC,
 a
Delaware limited liability corporation

		
	By:	 	 ALEXANDRIA REAL ESTATE EQUITIES, L.P.,

a Delaware limited partnership, managing member

			
		 	By:	 	ARE-QRS CORP.,
		 		 	 a Maryland corporation,
 general
partner

				
		 		 	By:	 	 /s/ Eric S. Johnson

		 		 	Its:	 	  

		 		 		 	Eric S. Johnson
		 		 		 	Vice President
		 		 		 	Real Estate Legal Affairs

  
 4 

 EXHIBIT A 

The Expansion Premises 
  

 

  
 A-1 

 EXHIBIT B 

Expansion Premises Work Letter 

THIS EXPANSION PREMISES WORK LETTER dated October 26, 2012 (this “Expansion Premises Work Letter”) is made and entered
into by and between ARE-MA REGION NO. 38, LLC, a Delaware limited liability company (“Landlord”), and SAGE THERAPEUTICS, INC., a Delaware corporation (“Tenant”), and is attached to and made a part of
that certain Lease Agreement dated as of December 21, 2011, as amended by that certain First Amendment to Lease of even date herewith (as amended, the “Lease”), by and between Landlord and Tenant. Any initially capitalized
terms used but not defined herein shall have the meanings given them in the Lease. 
 1. General Requirements. 

(a) Tenant’s Authorized Representative. Tenant designates Kimi Iguchi and Kiran Reddy (either such individual acting alone,
“Tenant’s Representative”) as the only persons authorized to act for Tenant pursuant to this Expansion Premises Work Letter. Landlord shall not be obligated to respond to or act upon any request, approval, inquiry or
other communication (“Communication”) from or on behalf of Tenant in connection with this Expansion Premises Work Letter unless such Communication is in writing from Tenant’s Representative. Tenant may change either
Tenant’s Representative at any time upon not less than 5 business days advance written notice to Landlord. Neither Tenant nor Tenant’s Representative shall be authorized to direct Landlord’s contractors in the performance of
Landlord’s Work (as hereinafter defined). 
 (b) Landlord’s Authorized Representative. Landlord designates Jeff McComish
and Joe Maguire (either such individual acting alone, “Landlord’s Representative”) as the only persons authorized to act for Landlord pursuant to this Expansion Premises Work Letter. Tenant shall not be obligated to respond to
or act upon any request, approval, inquiry or other Communication from or on behalf of Landlord in connection with this Expansion Premises Work Letter unless such Communication is in writing from Landlord’s Representative. Landlord may change
either Landlord’s Representative at any time upon not less than 5 business days advance written notice to Tenant. Landlord’s Representative shall be the sole persons authorized to direct Landlord’s contractors in the performance of
Landlord’s Work. 
 (c) Architects, Consultants and Contractors. Landlord and Tenant hereby acknowledge and agree that:
(i) the general contractor and any subcontractors for the Tenant Improvements shall be selected by Landlord, subject to Tenant’s approval, which approval shall not be unreasonably withheld, conditioned or delayed, and (ii) R.E. Dineen
shall be the architect (the “TI Architect”) for the Tenant Improvements. 
 2. Tenant Improvements. 

(a) Tenant Improvements Defined. As used herein, “Tenant Improvements” shall mean all improvements to the Expansion
Premises of a fixed and permanent nature as shown on the TI Construction Drawings, as defined in Section 2(c) below. Other than Landlord’s Work (as defined in Section 3(a) below, Landlord shall not have any obligation
whatsoever with respect to the finishing of the Expansion Premises for Tenant’s use and occupancy. 
 (b) Tenant’s Space
Plans. Landlord and Tenant acknowledge and agree that that certain plan PL-2 dated April 20, 2012, prepared by the TI Architect attached hereto as Schedule 1 (the “Space Plan”), the Basis of Design attached hereto as
Schedule 2 and the Scope of Work attached hereto as Schedule 3 have been approved by both Landlord and Tenant. Landlord and Tenant further acknowledge and agree that any changes to the Space Plan constitute a Change Request the cost of
which changes shall be paid for by Tenant. Tenant shall be solely responsible for all costs incurred by Landlord to alter the Building (or Landlord’s plans for the Building) as a result of Tenant’s requested changes. 

  
 B-1 

 (c) Working Drawings. Landlord shall cause the TI Architect to prepare and deliver to
Tenant for review and comment construction plans, specifications and drawings for the Tenant Improvements (“TI Construction Drawings”), which TI Construction Drawings shall be prepared substantially in accordance with the Space
Plan. Tenant shall be solely responsible for ensuring that the TI Construction Drawings reflect Tenant’s requirements for the Tenant Improvements. Tenant shall deliver its written comments on the TI Construction Drawings to Landlord not later
than 10 business days after Tenant’s receipt of the same; provided, however, that Tenant may not disapprove any matter that is consistent with the Space Plan without submitting a Change Request. Landlord and the TI Architect shall consider all
such comments in good faith and shall, within 10 business days after receipt, notify Tenant how Landlord proposes to respond to such comments, but Tenant’s review rights pursuant to the foregoing sentence shall not delay the design or
construction schedule for the Tenant Improvements. Any disputes in connection with such comments shall be resolved in accordance with Section 2(d) hereof. Provided that the design reflected in the TI Construction Drawings is consistent
with the Space Plan, Tenant shall approve the TI Construction Drawings submitted by Landlord, unless Tenant submits a Change Request. Once approved by Tenant, subject to the provisions of Section 4 below, Landlord shall not materially
modify the TI Construction Drawings except as may be reasonably required in connection with the issuance of the TI Permit (as defined in Section 3(b) below). 

(d) Approval and Completion. It is hereby acknowledged by Landlord and Tenant that the TI Construction Drawings must be completed and
approved no later than October 15, 2012, in order for the Landlord’s Work to be Substantially Complete by the Target Commencement Date (as defined in the Lease). Upon any dispute regarding the design of the Tenant Improvements, which is
not settled within 10 business days after notice of such dispute is delivered by one party to the other, Tenant may make the final decision regarding the design of the Tenant Improvements, provided (i) Tenant acts reasonably and such final
decision is either consistent with or a compromise between Landlord’s and Tenant’s positions with respect to such dispute, (ii) that all increases in costs and expenses resulting from any such decision by Tenant shall be payable by
Tenant, and (iii) Tenant’s decision will not affect the base Building, structural components of the Building or any Building systems. Any changes to the TI Construction Drawings following Landlord’s and Tenant’s approval of same
requested by Tenant shall be processed as provided in Section 4 hereof. 
 3. Performance of Landlord’s Work. 

(a) Definition of Landlord’s Work. As used herein, “Landlord’s Work” shall mean the work of constructing the
Tenant Improvements. 
 (b) Commencement and Permitting. Landlord shall commence construction of the Tenant Improvements upon
obtaining a building permit (the “TI Permit”) authorizing the construction of the Tenant Improvements consistent with the TI Construction Drawings approved by Tenant. The cost of obtaining the TI Permit shall be payable by Landlord.
Tenant shall assist Landlord in obtaining the TI Permit. If any Governmental Authority having jurisdiction over the construction of Landlord’s Work or any portion thereof shall impose terms or conditions upon the construction thereof that:
(i) are inconsistent with Landlord’s obligations hereunder, (ii) increase the cost of constructing Landlord’s Work, or (iii) will materially delay the construction of Landlord’s Work, Landlord and Tenant shall
reasonably and in good faith seek means by which to mitigate or eliminate any such adverse terms and conditions. 
 (c) Completion of
Landlord’s Work. Landlord shall (i) substantially complete or cause to be substantially completed Landlord’s Work in a good and workmanlike manner, in accordance with the TI Permit subject, in each case, to Minor Variations and
normal “punch list” items of a non-material nature that do not interfere with the use of the Expansion Premises, and (ii) obtain a certificate or temporary certificate of occupancy (or an equivalent approval) for the Expansion
Premises permitting lawful 

  
 B-2 

 
occupancy of the Expansion Premises (but specifically excluding any permits, licenses or other governmental approvals required to be obtained in connection with Tenant’s operations in the
Expansion Premises) (“Substantial Completion” or “Substantially Complete”). Upon Substantial Completion of Landlord’s Work, Landlord shall require the TI Architect and the general contractor to execute and
deliver, for the benefit of Tenant and Landlord, a Certificate of Substantial Completion in the form of the American Institute of Architects (“AIA”) document G704. For purposes of this Expansion Premises Work Letter, “Minor
Variations” shall mean any modifications reasonably required: (i) to comply with all applicable Legal Requirements and/or to obtain or to comply with any required permit (including the TI Permit); (ii) to comply with any request
by Tenant for modifications to Landlord’s Work; (iii) to comport with good design, engineering, and construction practices that are not material; or (iv) to make reasonable adjustments for field deviations or conditions encountered
during the construction of Landlord’s Work. 
 (d) Selection of Materials. Where more than one type of material or structure is
indicated on the TI Construction Drawings approved by Landlord and Tenant, the option will be selected at Landlord’s sole and absolute subjective discretion. As to all building materials and equipment that Landlord is obligated to supply under
this Expansion Premises Work Letter, Landlord shall select the manufacturer thereof in its sole and absolute subjective discretion. 
 (e)
Delivery of the Expansion Premises. When Landlord’s Work is Substantially Complete, subject to the remaining terms and provisions of this Section 3(e), Tenant shall accept the Expansion Premises. Tenant’s taking
possession and acceptance of the Expansion Premises shall not constitute a waiver of: (i) any warranty with respect to workmanship (including installation of equipment) or material (exclusive of equipment provided directly by manufacturers),
(ii) any non-compliance of Landlord’s Work with applicable Legal Requirements, or (iii) any claim that Landlord’s Work was not completed substantially in accordance with the TI Construction Drawings (subject to Minor Variations
and such other changes as are permitted hereunder) (collectively, a “Construction Defect”). Tenant shall have one year after Substantial Completion within which to notify Landlord of any such Construction Defect discovered by
Tenant, and Landlord shall use reasonable efforts to remedy or cause the responsible contractor to remedy any such Construction Defect within 30 days thereafter. Notwithstanding the foregoing, Landlord shall not be in default under the Lease if the
applicable contractor, despite Landlord’s reasonable efforts, fails to remedy such Construction Defect within such 30-day period, in which case Landlord shall have no further obligation with respect to such Construction Defect other than to
cooperate, at no cost to Landlord, with Tenant should Tenant elect to pursue a claim against such contractor. 
 (f) Tenant shall be
entitled to receive the benefit of all construction warranties and manufacturer’s equipment warranties relating to equipment installed in the Expansion Premises. If requested by Tenant, Landlord shall attempt to obtain extended warranties from
manufacturers and suppliers of such equipment, but the cost of any such extended warranties shall be borne solely by Tenant. Landlord shall promptly undertake and complete, or cause to be completed, all punch list items. 

(g) Commencement Date Delay. Except as otherwise provided in the Lease, Delivery of the Expansion Premises shall occur when
Landlord’s Work has been Substantially Completed, except to the extent that completion of Landlord’s Work shall have been actually delayed by any one or more of the following causes (“Tenant Delay”): 

(i) Tenant’s Representative was not available within 1 business day to give or receive any Communication or to take any
other action required to be taken by Tenant hereunder; 
 (ii) Tenant’s request for Change Requests (as defined in
Section 4(a) below) whether or not any such Change Requests are actually performed; 
 (iii) Construction of any
Change Requests; 

  
 B-3 

 (iv) Tenant’s request for materials, finishes or installations requiring
unusually long lead times; 
 (v) Tenant’s delay in reviewing, revising or approving plans and specifications beyond the
periods set forth herein; 
 (vi) Tenant’s delay in providing information critical to the normal progression of the
Project. Tenant shall provide such information as soon as reasonably possible, but in no event longer than one week after receipt of any request for such information from Landlord; 

(vii) Tenant’s delay in making payments to Landlord for Excess TI Costs (as defined in Section 5(b) below); or

 (viii) Any other act or omission by Tenant or any Tenant Party (as defined in the Lease), or persons employed by any of
such persons. 
 If Delivery is delayed for any of the foregoing reasons, then Landlord shall cause the TI Architect to certify the date on which the Tenant
Improvements would have been completed but for such Tenant Delay and such certified date shall be the date of Delivery. 
 4.
Changes. Any changes requested by Tenant to the Tenant Improvements after the delivery and approval by Landlord of the Space Plan shall be requested and instituted in accordance with the provisions of this Section 4 and shall be
subject to the written approval of Landlord and the TI Architect, such approval not to be unreasonably withheld, conditioned or delayed. 

(a) Tenant’s Request For Changes. If Tenant shall request changes to the Tenant Improvements (“Changes”), Tenant
shall request such Changes by notifying Landlord in writing in substantially the same form as the AIA standard change order form (a “Change Request”), which Change Request shall detail the nature and extent of any such Change. Such
Change Request must be signed by Tenant’s Representative. Landlord shall, before proceeding with any Change, respond to Tenant as soon as is reasonably possible with an estimate of: (i) the time it will take, and (ii) the
architectural and engineering fees and costs that will be incurred, to analyze such Change Request (which costs shall be paid by Tenant to the extent actually incurred, whether or not such change is implemented). Landlord shall thereafter submit to
Tenant in writing, within 5 business days of receipt of the Change Request (or such longer period of time as is reasonably required depending on the extent of the Change Request), an analysis of the additional cost or savings involved, including,
without limitation, architectural and engineering costs and the period of time, if any, that the Change will extend the date on which Landlord’s Work will be Substantially Complete. Any such delay in the completion of Landlord’s Work
caused by a Change, including any suspension of Landlord’s Work while any such Change is being evaluated and/or designed, shall be Tenant Delay. 

(b) Implementation of Changes. If Tenant: (i) approves in writing the cost or savings and the estimated extension in the time for
completion of Landlord’s Work, if any, and (ii) deposits with Landlord any Excess TI Costs required pursuant to Section 5(b) below in connection with such Change, Landlord shall cause the approved Change to be instituted.
Notwithstanding any approval or disapproval by Tenant of any estimate of the delay caused by such proposed Change, the TI Architect’s determination of the amount of Tenant Delay in connection with such Change shall be final and binding on
Landlord and Tenant. 
 5. Costs. 

(a) TI Costs. Landlord shall be responsible for all hard and soft costs and expenses for the design and performance of Landlord’s
Work including, without limitation, design, permits and construction costs in connection with the construction of the Tenant Improvements, including, without limitation, the 

  
 B-4 

 
cost of preparing the TI Construction Drawings and the Space Plan and Landlord’s out-of-pocket expenses (collectively, “TI Costs”). Notwithstanding anything to the contrary
contained herein, in no event shall Landlord be required to pay for any furniture, personal property or other non-Building system materials or equipment, including, but not limited to, Tenant’s voice or data cabling, not incorporated into the
Tenant Improvements. 
 (b) Excess TI Costs. Notwithstanding anything to the contrary contained herein, Tenant acknowledges and
agrees that Landlord shall have no responsibility for any costs arising from or related to Tenant’s changes to the Space Plan or TI Construction Drawings, Tenant Delays, the cost of Changes and Change Requests (collectively, “Excess TI
Costs”). Tenant shall deposit with Landlord 50% of the Excess TI Costs as a condition precedent to Landlord’s obligation to complete the Tenant Improvements and the remaining 50% of the Excess TI Costs upon Substantial Completion of
the Tenant Improvements. If Tenant fails to deposit any Excess TI Costs with Landlord, Landlord shall have all of the rights and remedies set forth in the Lease for nonpayment of Rent (including, but not limited to, the right to interest at the
Default Rate and the right to assess a late charge). For purposes of any litigation instituted with regard to such amounts, those amounts will be deemed Rent under the Lease. 

6. Tenant Access. 
 (a)
Tenant’s Access Rights. Landlord hereby agrees to permit Tenant access, at Tenant’s sole risk and expense, to the Expansion Premises (i) 14 days prior to the Commencement Date to perform any work (“Tenant’s
Work”) required by Tenant other than Landlord’s Work, provided that such Tenant’s Work is coordinated with the TI Architect and the general contractor, and complies with the Lease and all other reasonable restrictions and
conditions Landlord may impose, and (ii) prior to the completion of Landlord’s Work, to inspect and observe work in process; all such access shall be during normal business hours or at such other times as are reasonably designated by
Landlord. Any entry by Tenant shall comply with all established safety practices of Landlord’s contractor and Landlord until completion of Landlord’s Work and acceptance thereof by Tenant. 

(b) No Interference. Neither Tenant nor any Tenant Party (as defined in the Lease) shall interfere with the performance of
Landlord’s Work, nor with any inspections or issuance of final approvals by applicable Governmental Authorities, and upon any such interference, Landlord shall have the right to exclude Tenant and any Tenant Party from the Expansion Premises
and the Project until Substantial Completion of Landlord’s Work. 
 (c) No Acceptance of Expansion Premises. The fact that
Tenant may, with Landlord’s consent, enter into the Expansion Premises prior to the date Landlord’s Work is Substantially Complete for the purpose of performing Tenant’s Work shall not be deemed an acceptance by Tenant of possession
of the Expansion Premises, but in such event Tenant shall defend with counsel reasonably acceptable by Landlord, indemnify and hold Landlord harmless from and against any loss of or damage to Tenant’s property, completed work, fixtures,
equipment, materials or merchandise, and from liability for death of, or injury to, any person, caused by the act or omission of Tenant or any Tenant Party. 

7. Miscellaneous. 
 (a)
Consents. Whenever consent or approval of either party is required under this Expansion Premises Work Letter, that party shall not unreasonably withhold, condition or delay such consent or approval, unless expressly set forth herein to the
contrary. 
 (b) Modification. No modification, waiver or amendment of this Expansion Premises Work Letter or of any of its
conditions or provisions shall be binding upon Landlord or Tenant unless in writing signed by Landlord and Tenant. 

  
 B-5 

 Schedule 1 

Space Plan 
  

 

  
 B-6 

 Schedule 2 

Basis of Design 
 Sage Therapeutics
Expansion 
 215 First Street, Floor 2 
 Cambridge,
Massachusetts 
 ARCHITECTURAL – BASIS OF DESIGN 

PART I – GENERAL 
 The scope of this improvement project is
predicated on the following: to provide new tenant improvements to meet the specific demands of Sage Therapeutics and State and local codes; and to provide new construction systems and materials In match the existing design and finish standards in
place. 
  

	1.0	ARCHITECTURAL – BASIS OF DESIGN 

  

	 	A.	Codes and Standard 

  

	 	1.	Codes and standards pertaining to this section will include, but not be limited to the following: 

  

	 	a.	International Building Code 2009 

  

	 	b.	International Existing Building Code 2009 

  

	 	c.	Massachusetts Architectural Access Board Regs. CMR 521. 

  

	 	d.	Americans With Disabilities Act and Architectural Barriers Act – Accessibility Guidelines 2004 

  

	 	e.	National Fire Protection Association (NFPA). 

  

	 	B.	Interior Finishes include the following: 

  

	 	1.	Flooring and Base 

  

	 	a.	Carpeting, installed in the direct glue-down method, with 4” high vinyl wall base. 

  

	 	2.	Walls 

  

	 	a.	Latex painted gypsum wall board. 

  

	 	3.	Ceilings 

  

	 	a.	No finished ceilings in Office Areas: open to structure above. 

  

	 	C.	Interior Partitions 

  

	 	a.	Full height, metal stud and gypsum wall board with unfaced acoustic batt insulation. 

  

	 	D.	Doors and Hardware to include the following: 

  

	 	1.	Doors and Frames 

  

	 	a.	Solid core wood doors with natural finished maple veneer. 

  

	 	b.	Hollow metal frame with painted finish. 

  

	 	2.	Door Hardware 

  

	 	a.	Lever handle, cylindrical locksets. 

  

	 	b.	Heavy duly ball bearing hinges. 

  

	 	c.	Door stops. 

  

					
	 R. E. Dinneen Architects
 & Planners,
Inc.
	  	 ARCHITECTURAL – BASIS OF DESIGN

Page 1 of 2
	  	015 October 2012

 B-7 

 Sage Therapeutics Expansion 

215 First Street, Floor 2 
 Cambridge, Massachusetts 

 

	 	3.	Interior glazing 

  

	 	a.	Full size, clear safety glass vision panels for office doors. 

  

	 	E.	Lighting 

 Office 
  

	 	a.	Pendant mounted fluorescent light fixtures. 

 END OF SECTION 

  

					
	 R. E. Dinneen Architects
 & Planners,
Inc.
	  	 ARCHITECTURAL – BASIS OF DESIGN

Page 2 of 2
	  	015 October 2012

 B-8 

 Schedule 3 

Scope of Work 
  

 
 Alexandria Real Estate 

215 First Street, Cambridge, MA 
 Sage Therapeutics
Expansion 
 Bid Estimate 
  

					
	 Division/Description
	  	Qty	  	UM
			
	 Demolition
	  		  	
		
	 Existing flooring
	  	to remain
	 Remove existing partitions & millwork per plan
	  		  	
	 Temp protection & isolation
	  		  	
	 Laborer for temp protection
	  		  	
	 Dumpsters for demolition
	  	 	  	 
			
	 Rough and Finish Carpentry
	  		  	
			
	 Miscellaneous rough carpentry.
	  		  	
	 Install doors & hardware
	  	5 ea
			
	 Thermal and Moisture Protection
	  	 	  	 
			
	 Doors, Frames and Hardware
	  		  	
		
	 3 x 6’-8” wood doors, frames & hardware
	  	5 ea
	 Specialty hardware / Card access systems
	  	EXCLUDED
			
	 Glass and Glazing
	  		  	
			
	 Full door glazing
	  		  	
	 Borrowed lites / transom glass
	  	EXCLUDED
			
	 Gypsum Drywall
	  		  	
			
	 Full ht. GWB partitions
	  		  	
	 GWB soffits & ceilings
	  	EXCLUDED
	 Install door frames
	  		  	
	 Delivery / loading & distribution
	  	 	  	 
			
	 Acoustic Ceilings
	  		  	
	 	  	No work

  
 Page 1 of 3 

B-9 

					
	 Division/Description
	  	Qty	  	UM
	 Flooring Systems
	  		  	
		
	 Carpet
	  	Existing to remain
	 Allowance to patch at demo as required (labor only)
	  	1 alw
	 Patch carpet materials (from ARE stock)
	  		  	
	 Vinylbase
	  	275 lf
			
	 Painting
	  		  	
		
	 Paint new & existing walls as required
	  	1 ls
	 Paint door frames
	  	5 ea
	 Paint exposed mechanical (duct, etc.)
	  	 	  	 
			
	 Specialties
	  		  	
		
	 Cubicles & office furniture
	  	By others
	 Telephone & AV systems
	  	By others
			
	 Fire Protection
	  		  	
		
	 Rework sprinkler heads for new layout
	  	1 ls
			
	 Plumbing
	  	 	  	 
			
	 HVAC
	  		  	
		
	 New 1.5 split heat pump system
	  	1 ls
	 New duct distribution per new layout
	  	1 ls
	 Local t-stat
	  	1ea
	 Locate ACCU in existing mezz
	  	1 ea
			
	 Electrical, Fire Alarm
	  		  	
		
	 New & relocated lighting to match existing
	  	1 ls
	 General power wiring to match existing
	  	1 ls
	 Emerg. Exit lighting per code
	  	1 ls
	 Fire alarm
	  	not req’d
	 Tele / data & security wiring
	  	EXCLUDED
			
	 General
	  		  	
		
	 Premium time/Second Shift allowance
	  	EXCLUDED

  
 Page 2 of 3 

B-10 

					
	 Division/Description
	  	 Qty
	  	 UM

	 Supervison & management
	  	
		
	 Project Superintendent.
	  	3 wks
	 Second Shift Superintendent
	  	EXCLUDED
	 Preconstruction
	  	
	 Project Manager
	  	1 ls
	 Project Admin Assistant.
	  	1 ls
	 Project Accountant.
	  	1 ls
		
	 General Conditions
	  	 
		
	 Engineering
	  	
		
	 Architectural services (RE Dinneen)
	  	1 qt
	 MEPFP Engineering (AHA)
	  	1 qt
	 Structural engineering (TBD)
	  	EXCLUDED
		
	 Insurance and Permits
	  	
			
	 General Liability Insurance
	  	0.70%	  	
	 Building Permits
	  	1.50%	  	 
		
	 Contingency
	  	 1 ls

		
	 FEE
	  	 1 ls

		
	 Total budget
	  	 

  
 Page 3 of 3 

B-11 

 SECOND AMENDMENT TO LEASE 

THIS SECOND AMENDMENT TO LEASE (this “Second Amendment”) is made as of May 9, 2013, by and between ARE-MA REGION NO. 38, LLC, a Delaware limited liability company (“Landlord”), and SAGE THERAPEUTICS, INC., a Delaware corporation (“Tenant”). 

RECITALS 
 A.
Landlord and Tenant are now parties to that certain Lease Agreement dated as of December 21, 2011, as amended by that certain First Amendment to Lease dated as of October 26, 2012 (as amended, the “Lease”). Pursuant to the
Lease, Tenant leases certain premises consisting of approximately 6,500 rentable square feet of space (“Existing Premises”) in a building located at 215 First Street, Cambridge, Massachusetts (“Building”). The
Existing Premises are more particularly described in the Lease. Capitalized terms used herein without definition shall have the meanings defined for such terms in the Lease. 

B. Landlord and Tenant desire, subject to the terms and conditions set forth below, to amend the Lease to, among other things, expand
the size of the Existing Premises by adding approximately 4,100 rentable square feet of space on the second floor of the Building. 

NOW, THEREFORE, in consideration of the foregoing Recitals, which are incorporated herein by this reference, the mutual promises and
conditions contained herein, and for other good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, Landlord and Tenant hereby agree as follows: 

 

	1.	Second Expansion Premises. In addition to the Existing Premises, commencing on the Second Expansion Premises Commencement Date (as defined below), Landlord leases to Tenant, and Tenant leases from
Landlord, that certain portion of the second floor of the Building, containing approximately 4,100 rentable square feet, as shown on Exhibit A attached hereto (the “Second Expansion Premises”). 

 

	2.	Delivery. Landlord shall use reasonable efforts to deliver the Second Expansion Premises to Tenant on or before the Target Second Expansion Premises Commencement Date with Landlord’s Work
Substantially Completed (“Delivery” or “Deliver”). If Landlord fails to timely Deliver the Second Expansion Premises, Landlord shall not be liable to Tenant for any loss or damage resulting therefrom, and the Lease
with respect to the Second Expansion Premises shall not be void or voidable. As used herein, the terms “Landlord’s Work” and “Substantially Completed” shall have the meanings set forth for such terms in the
work letter attached to this Second Amendment as Exhibit B (“Second Expansion Premises Work Letter”). 

The “Second Expansion Premises Commencement Date” shall be the date that Landlord delivers the Second Expansion Premises to
Tenant. The “Target Expansion Premises Commencement Date” shall be July 19, 2013. Upon request of Landlord, Tenant shall execute and deliver a written acknowledgment of the Second Expansion Premises Commencement Date in a form
substantially similar to the form of the “Acknowledgement of Commencement Date” attached to the Lease as Exhibit G; provided, however, Tenant’s failure to execute and deliver such acknowledgment shall not
affect Landlord’s rights hereunder. 
 Except as set forth in the Second Expansion Premises Work Letter: (i) Tenant shall accept
the Second Expansion Premises in their condition as of the Second Expansion Premises Commencement Date, subject to all applicable Legal Requirements; (ii) Landlord shall have no obligation for any defects in the Second Expansion Premises; and
(iii) Tenant’s taking possession of the Second Expansion Premises shall be conclusive evidence that Tenant accepts the Second Expansion Premises and that the Second Expansion Premises were in good condition at the time possession was
taken. The Second Expansion Premises shall be delivered to Tenant without any furniture. 

  
 1 

 Tenant agrees and acknowledges that neither Landlord nor any agent of Landlord has made any
representation or warranty with respect to the condition of all or any portion of the Second Expansion Premises, and/or the suitability of the Second Expansion Premises for the conduct of Tenant’s business, and Tenant waives any implied
warranty that the Second Expansion Premises are suitable for the Permitted Use. 
  

	3.	Definition of Premises. Commencing on the Second Expansion Premises Commencement Date, the defined term “Premises” on Page 1 of the Lease is deleted in its entirety and replaced with the
following: 

 “Premises: That portion of the second floor of the Building (as defined below)
containing approximately 10,600 rentable square feet, consisting of (i) approximately 5,900 rentable square feet (“Original Premises”), (ii) approximately 600 rentable square feet (“Expansion Premises”),
and approximately 4,100 rentable square feet (“Second Expansion Premises”), all as determined by Landlord, as shown on Exhibit A.” 

Exhibit A attached to the Lease is amended as of the Second Expansion Premises Commencement Date to include Exhibit A attached to
this Second Amendment. 
  

	4.	Base Rent. Tenant shall continue to pay Base Rent for the Existing Premises as provided for in the Lease through the Expiration Date (as defined in Section 6 below). Commencing on the Second
Expansion Premises Commencement Date, Tenant shall pay Base Rent for the Second Expansion Premises in the amount of $25.00 per rentable square foot of the Second Expansion Premises per year. Base Rent for the Second Expansion Premises shall be
increased on each annual anniversary of Second Expansion Premises Commencement Date (each an “Adjustment Date”) by multiplying the Base Rent payable for the Second Expansion Premises immediately before such Adjustment Date by 3% and
adding the resulting amount to the Base Rent payable for the Second Expansion Premises immediately before such Adjustment Date. Base Rent for the Second Expansion Premises, as so adjusted, shall thereafter be due as provided herein. Base Rent
adjustments for any fractional calendar month shall be prorated. 

  

	5.	Tenant’s Share. Commencing on the Second Expansion Premises Commencement Date, the defined term “Tenant’s Share” on page 1 of the Lease is deleted in its entirety and replaced
with the following: 

 “Tenant’s Share for Original Premises and Expansion Premises:
1.77% 
 Tenant’s Share for Second Expansion Premises: 1.12%” 

Notwithstanding anything to the contrary contained in the Lease, (i) the Base Year for Operating Expanses with respect to the Second
Expansion Premises only shall be 2013, (ii) the Base Year for Taxes with respect to the Second Expansion Premises only shall be July 1, 2013 – June 30, 2014, and (iii) Operating Expenses for the Second Expansion Premises
shall include the costs of Landlord’s third party manager (which shall not exceed 5% of Base Rent) or, if there is no third party property manager, administration rent in the amount of 5.0% of Base Rent. 

 

	6.	Base Term. Commencing on the Second Expansion Premises Commencement Date, the defined term “Base Term” on page 1 of the Lease is deleted in its entirety and replaced with the following:

 “Base Term: Beginning (i) with respect to the Original Premises, on the Commencement Date,
(ii) with respect to the Expansion Premises, on the Expansion Premises Commencement 

  
 2 

 
Date, and (iii) with respect to the Second Expansion Premises, on the Second Expansion Premises Commencement Date and, with respect to the entire Premises ending on February 28, 2017
(“Expiration Date”).” 
  

	7.	Rentable Area of Premises. Commencing on the Second Expansion Premises Commencement Date, the defined term “Rentable Area of Premises” on page 1 of the Lease is deleted in its entirety and
replaced with the following: 

 “Rentable Area: Approximately 10,600 square feet” 

 

	8.	Parking. Commencing on the Second Expansion Premises Commencement Date, Tenant’s license for parking at the surface parking lots at the Project or at the “Brown Lot” at 100 Binney Street,
Cambridge, Massachusetts, pursuant to Section 8 of the Lease, shall be increased by 4 parking space so that Tenant shall have a license to use a total of 11 parking spaces. Commencing on the Second Expansion Premises Commencement Date,
Tenant shall pay, as Additional Rent, $220 per month for such additional parking space. 

  

	9.	Right of First Refusal. Section 35 of the Lease is hereby deleted in its entirety and of no further force or effect and Tenant shall have no further rights of first refusal under the Lease.

  

	10.	Brokers. Landlord and Tenant each represents and warrants that it has not dealt with any broker, agent or other person (collectively, “Broker”) in connection with the transaction reflected
in this Second Amendment and that no Broker brought about this transaction, other than Richards, Barry Joyce & Partners and Cushman & Wakefield. Landlord and Tenant each hereby agrees to indemnify and hold the other harmless from
and against any claims by any Broker claiming a commission or other form of compensation by virtue of having dealt with Tenant or Landlord, as applicable, with regard to this leasing transaction. 

 

	11.	Miscellaneous. 

 a. This Second Amendment is the entire agreement between
the parties with respect to the subject matter hereof and supersedes all prior and contemporaneous oral and written agreements and discussions. This Second Amendment may be amended only by an agreement in writing, signed by the parties hereto. 

b. This Second Amendment is binding upon and shall inure to the benefit of the parties hereto, their respective successors and assigns.

 c. This Second Amendment may be executed in any number of counterparts, each of which shall be deemed an original, but all of which
when taken together shall constitute one and the same instrument. The signature page of any counterpart may be detached therefrom without impairing the legal effect of the signature(s) thereon provided such signature page is attached to any other
counterpart identical thereto except having additional signature pages executed by other parties to this Second Amendment attached thereto. 

d. Except as amended and/or modified by this Second Amendment, the Lease is hereby ratified and confirmed and all other terms of the
Lease shall remain in full force and effect, unaltered and unchanged by this Second Amendment. In the event of any conflict between the provisions of this Second Amendment and the provisions of the Lease, the provisions of this Second Amendment
shall prevail. Whether or not specifically amended by this Second Amendment, all of the terms and provisions of the Lease are hereby amended to the extent necessary to give effect to the purpose and intent of this Second Amendment. 

  
 3 

 IN WITNESS WHEREOF, the parties hereto have executed this Second Amendment as of the day
and year first above written. 
  

							
	TENANT:
	
	 SAGE THERAPEUTICS, INC.,

a Delaware corporation

		
	By:	 	

		 	  

	Its:	 	  

	
	LANDLORD:
	
	 ARE-MA REGION NO. 38, LLC,
 a
Delaware limited liability company

		
	By:	 	 ALEXANDRIA REAL ESTATE EQUITIES, L.P.,

a Delaware limited partnership, managing member

			
		 	By:	 	ARE-QRS CORP.,
		 		 	a Maryland corporation,
		 		 	general partner
				
		 		 	By:	 	 /s/ Eric S. Johnson

		 		 	Its:	 	  

		 		 		 	Eric S. Johnson
		 		 		 	Vice President
		 		 		 	Real Estate Legal Affairs

  
 4 

 EXHIBIT A 

The Second Expansion Premises 
  

 

  
 A-1 

 EXHIBIT B 

Second Expansion Premises Work Letter 

THIS SECOND EXPANSION PREMISES WORK LETTER dated May 9, 2013 (this “Second Expansion Premises Work Letter”) is made and
entered into by and between ARE-MA REGION NO. 38, LLC, a Delaware limited liability company (“Landlord”), and SAGE THERAPEUTICS, INC., a Delaware corporation (“Tenant”), and is attached to and
made a part of that certain Lease Agreement dated as of December 21, 2011, as amended by that certain First Amendment to Lease dated as of October 26, 2012, and as further amended by that certain Second Amendment to Lease of even date
herewith (as amended, the “Lease”), by and between Landlord and Tenant. Any initially capitalized terms used but not defined herein shall have the meanings given them in the Lease. 

1. General Requirements. 

(a) Tenant’s Authorized Representative. Tenant designates Kimi Iguchi and Kiran Reddy (either such individual acting alone,
“Tenant’s Representative”) as the only persons authorized to act for Tenant pursuant to this Second Expansion Premises Work Letter. Landlord shall not be obligated to respond to or act upon any request, approval, inquiry or
other communication (“Communication”) from or on behalf of Tenant in connection with this Second Expansion Premises Work Letter unless such Communication is in writing from Tenant’s Representative. Tenant may change either
Tenant’s Representative at any time upon not less than 5 business days advance written notice to Landlord. Neither Tenant nor Tenant’s Representative shall be authorized to direct Landlord’s contractors in the performance of
Landlord’s Work (as hereinafter defined). 
 (b) Landlord’s Authorized Representative. Landlord designates Jeff McComish
and Joe Maguire (either such individual acting alone, “Landlord’s Representative”) as the only persons authorized to act for Landlord pursuant to this Second Expansion Premises Work Letter. Tenant shall not be obligated to
respond to or act upon any request, approval, inquiry or other Communication from or on behalf of Landlord in connection with this Second Expansion Premises Work Letter unless such Communication is in writing from Landlord’s Representative.
Landlord may change either Landlord’s Representative at any time upon not less than 5 business days advance written notice to Tenant. Landlord’s Representative shall be the sole persons authorized to direct Landlord’s contractors in
the performance of Landlord’s Work. 
 (c) Architects, Consultants and Contractors. Landlord and Tenant hereby acknowledge and
agree that: (i) the general contractor and any subcontractors for the Tenant Improvements shall be selected by Landlord, subject to Tenant’s approval, which approval shall not be unreasonably withheld, conditioned or delayed, and
(ii) R.E. Dineen shall be the architect (the “TI Architect”) for the Tenant Improvements. 
 2. Tenant
Improvements. 
 (a) Tenant Improvements Defined. As used herein, “Tenant Improvements” shall mean all
improvements to the Second Expansion Premises of a fixed and permanent nature as shown on the TI Construction Drawings, as defined in Section 2(c) below. Other than Landlord’s Work (as defined in Section 3(a) below,
Landlord shall not have any obligation whatsoever with respect to the finishing of the Second Expansion Premises for Tenant’s use and occupancy. 

(b) Tenant’s Space Plans. Landlord and Tenant acknowledge and agree that that certain plan attached hereto as Schedule 1
(the “Space Plan”) and the Basis of Design attached hereto as Schedule 2 have been approved by both Landlord and Tenant. Landlord and Tenant further acknowledge and agree that any changes to the Space Plan constitute a Change
Request the cost of which changes shall be paid for by Tenant. Tenant shall be solely responsible for all costs incurred by Landlord to alter the Building (or Landlord’s plans for the Building) as a result of Tenant’s requested changes.

  
 B-1 

 (c) Working Drawings. Landlord shall cause the TI Architect to prepare and deliver to
Tenant for review and comment construction plans, specifications and drawings for the Tenant Improvements (“TI Construction Drawings”), which TI Construction Drawings shall be prepared substantially in accordance with the Space
Plan. Tenant shall be solely responsible for ensuring that the TI Construction Drawings reflect Tenant’s requirements for the Tenant Improvements. Tenant shall deliver its written comments on the TI Construction Drawings to Landlord not later
than 10 business days after Tenant’s receipt of the same; provided, however, that Tenant may not disapprove any matter that is consistent with the Space Plan without submitting a Change Request. Landlord and the TI Architect shall consider all
such comments in good faith and shall, within 10 business days after receipt, notify Tenant how Landlord proposes to respond to such comments, but Tenant’s review rights pursuant to the foregoing sentence shall not delay the design or
construction schedule for the Tenant Improvements. Any disputes in connection with such comments shall be resolved in accordance with Section 2(d) hereof. Provided that the design reflected in the TI Construction Drawings is consistent
with the Space Plan, Tenant shall approve the TI Construction Drawings submitted by Landlord, unless Tenant submits a Change Request. Once approved by Tenant, subject to the provisions of Section 4 below, Landlord shall not materially
modify the TI Construction Drawings except as may be reasonably required in connection with the issuance of the TI Permit (as defined in Section 3(b) below). 

(d) Approval and Completion. It is hereby acknowledged by Landlord and Tenant that the TI Construction Drawings must be completed and
approved no later than May 16, 2013, in order for the Landlord’s Work to be Substantially Complete by the Target Second Expansion Premises Commencement Date (as defined in the Lease). Upon any dispute regarding the design of the Tenant
Improvements, which is not settled within 10 business days after notice of such dispute is delivered by one party to the other, Tenant may make the final decision regarding the design of the Tenant Improvements, provided (i) Tenant acts
reasonably and such final decision is either consistent with or a compromise between Landlord’s and Tenant’s positions with respect to such dispute, (ii) that all increases in costs and expenses resulting from any such decision by
Tenant shall be payable by Tenant, and (iii) Tenant’s decision will not affect the base Building, structural components of the Building or any Building systems. Any changes to the TI Construction Drawings following Landlord’s and
Tenant’s approval of same requested by Tenant shall be processed as provided in Section 4 hereof. 
 3. Performance of
Landlord’s Work. 
 (a) Definition of Landlord’s Work. As used herein, “Landlord’s Work” shall
mean the work of constructing the Tenant Improvements. 
 (b) Commencement and Permitting. Landlord shall commence construction of
the Tenant Improvements upon obtaining a building permit (the “TI Permit”) authorizing the construction of the Tenant Improvements consistent with the TI Construction Drawings approved by Tenant. The cost of obtaining the TI Permit
shall be payable by Landlord. Tenant shall assist Landlord in obtaining the TI Permit. If any Governmental Authority having jurisdiction over the construction of Landlord’s Work or any portion thereof shall impose terms or conditions upon the
construction thereof that: (i) are inconsistent with Landlord’s obligations hereunder, (ii) increase the cost of constructing Landlord’s Work, or (iii) will materially delay the construction of Landlord’s Work, Landlord
and Tenant shall reasonably and in good faith seek means by which to mitigate or eliminate any such adverse terms and conditions. 
 (c)
Completion of Landlord’s Work. Landlord shall (i) substantially complete or cause to be substantially completed Landlord’s Work in a good and workmanlike manner, in accordance with the TI Permit subject, in each case, to Minor
Variations and normal “punch list” items of a non-material nature that do not interfere with the use of the Second Expansion Premises, and (ii) obtain a certificate or temporary certificate of occupancy (or an equivalent approval) for
the Second Expansion Premises 

  
 B-2 

 
permitting lawful occupancy of the Second Expansion Premises (but specifically excluding any permits, licenses or other governmental approvals required to be obtained in connection with
Tenant’s operations in the Second Expansion Premises)(“Substantial Completion” or “Substantially Complete”). Upon Substantial Completion of Landlord’s Work, Landlord shall require the TI Architect and the
general contractor to execute and deliver, for the benefit of Tenant and Landlord, a Certificate of Substantial Completion in the form of the American Institute of Architects (“AIA”) document G704. For purposes of this Second
Expansion Premises Work Letter, “Minor Variations” shall mean any modifications reasonably required: (i) to comply with all applicable Legal Requirements and/or to obtain or to comply with any required permit (including the TI
Permit); (ii) to comply with any request by Tenant for modifications to Landlord’s Work; (iii) to comport with good design, engineering, and construction practices that are not material; or (iv) to make reasonable adjustments for
field deviations or conditions encountered during the construction of Landlord’s Work. 
 (d) Selection of Materials. Where more
than one type of material or structure is indicated on the TI Construction Drawings approved by Landlord and Tenant, the option will be selected at Landlord’s sole and absolute subjective discretion. As to all building materials and equipment
that Landlord is obligated to supply under this Second Expansion Premises Work Letter, Landlord shall select the manufacturer thereof in its sole and absolute subjective discretion. 

(e) Delivery of the Second Expansion Premises. When Landlord’s Work is Substantially Complete, subject to the remaining terms and
provisions of this Section 3(e), Tenant shall accept the Second Expansion Premises. Tenant’s taking possession and acceptance of the Second Expansion Premises shall not constitute a waiver of: (i) any warranty with respect to
workmanship (including installation of equipment) or material (exclusive of equipment provided directly by manufacturers), (ii) any non-compliance of Landlord’s Work with applicable Legal Requirements, or (iii) any claim that
Landlord’s Work was not completed substantially in accordance with the TI Construction Drawings (subject to Minor Variations and such other changes as are permitted hereunder) (collectively, a “Construction Defect”). Tenant
shall have one year after Substantial Completion within which to notify Landlord of any such Construction Defect discovered by Tenant, and Landlord shall use reasonable efforts to remedy or cause the responsible contractor to remedy any such
Construction Defect within 30 days thereafter. Notwithstanding the foregoing, Landlord shall not be in default under the Lease if the applicable contractor, despite Landlord’s reasonable efforts, fails to remedy such Construction Defect within
such 30-day period, in which case Landlord shall have no further obligation with respect to such Construction Defect other than to cooperate, at no cost to Landlord, with Tenant should Tenant elect to pursue a claim against such contractor. 

(f) Tenant shall be entitled to receive the benefit of all construction warranties and manufacturer’s equipment warranties relating to
equipment installed in the Second Expansion Premises. If requested by Tenant, Landlord shall attempt to obtain extended warranties from manufacturers and suppliers of such equipment, but the cost of any such extended warranties shall be borne solely
by Tenant. Landlord shall promptly undertake and complete, or cause to be completed, all punch list items. 
 (g) Commencement Date
Delay. Except as otherwise provided in the Lease, Delivery of the Second Expansion Premises shall occur when Landlord’s Work has been Substantially Completed, except to the extent that completion of Landlord’s Work shall have been
actually delayed by any one or more of the following causes (“Tenant Delay”): 
 (i) Tenant’s
Representative was not available within 1 business day to give or receive any Communication or to take any other action required to be taken by Tenant hereunder; 

(ii) Tenant’s request for Change Requests (as defined in Section 4(a) below) whether or not any such Change
Requests are actually performed; 
 (iii) Construction of any Change Requests; 

  
 B-3 

 (iv) Tenant’s request for materials, finishes or installations requiring
unusually long lead times; 
 (v) Tenant’s delay in reviewing, revising or approving plans and specifications beyond the
periods set forth herein; 
 (vi) Tenant’s delay in providing information critical to the normal progression of the
Project. Tenant shall provide such information as soon as reasonably possible, but in no event longer than one week after receipt of any request for such information from Landlord; 

(vii) Tenant’s delay in making payments to Landlord for Excess TI Costs (as defined in Section 5(b) below); or

 (viii) Any other act or omission by Tenant or any Tenant Party (as defined in the Lease), or persons employed by any of
such persons. 
 If Delivery is delayed for any of the foregoing reasons, then Landlord shall cause the TI Architect to certify the date on which the Tenant
Improvements would have been completed but for such Tenant Delay and such certified date shall be the date of Delivery. 
 4.
Changes. Any changes requested by Tenant to the Tenant Improvements after the delivery and approval by Landlord of the Space Plan shall be requested and instituted in accordance with the provisions of this Section 4 and shall be
subject to the written approval of Landlord and the TI Architect, such approval not to be unreasonably withheld, conditioned or delayed. 

(a) Tenant’s Request For Changes. If Tenant shall request changes to the Tenant Improvements (“Changes”), Tenant
shall request such Changes by notifying Landlord in writing in substantially the same form as the AIA standard change order form (a “Change Request”), which Change Request shall detail the nature and extent of any such Change. Such
Change Request must be signed by Tenant’s Representative. Landlord shall, before proceeding with any Change, respond to Tenant as soon as is reasonably possible with an estimate of: (i) the time it will take, and (ii) the
architectural and engineering fees and costs that will be incurred, to analyze such Change Request (which costs shall be paid by Tenant to the extent actually incurred, whether or not such change is implemented). Landlord shall thereafter submit to
Tenant in writing, within 5 business days of receipt of the Change Request (or such longer period of time as is reasonably required depending on the extent of the Change Request), an analysis of the additional cost or savings involved, including,
without limitation, architectural and engineering costs and the period of time, if any, that the Change will extend the date on which Landlord’s Work will be Substantially Complete. Any such delay in the completion of Landlord’s Work
caused by a Change, including any suspension of Landlord’s Work while any such Change is being evaluated and/or designed, shall be Tenant Delay. 

(b) Implementation of Changes. If Tenant: (i) approves in writing the cost or savings and the estimated extension in the time for
completion of Landlord’s Work, if any, and (ii) deposits with Landlord any Excess TI Costs required pursuant to Section 5(b) below in connection with such Change, Landlord shall cause the approved Change to be instituted.
Notwithstanding any approval or disapproval by Tenant of any estimate of the delay caused by such proposed Change, the TI Architect’s determination of the amount of Tenant Delay in connection with such Change shall be final and binding on
Landlord and Tenant. 
 5. Costs. 

(a) TI Costs. Landlord shall be responsible for all hard and soft costs and expenses for the design and performance of Landlord’s
Work including, without limitation, design, permits and construction costs in connection with the construction of the Tenant Improvements, including, without limitation, the 

  
 B-4 

 
cost of preparing the TI Construction Drawings and the Space Plan and Landlord’s out-of-pocket expenses, up to $50.00 per rentable square foot of the Second Expansion Premises, or $205,000
in the aggregate (collectively, “TI Costs”). Notwithstanding anything to the contrary contained herein, in no event shall Landlord be required to pay for any furniture, personal property or other non-Building system materials or
equipment, including, but not limited to, Tenant’s voice or data cabling, not incorporated into the Tenant Improvements. 
 (b)
Excess TI Costs. Notwithstanding anything to the contrary contained herein, Tenant acknowledges and agrees that Landlord shall have no responsibility for any costs arising from or related to Tenant’s changes to the Space Plan or TI
Construction Drawings, Tenant Delays, the cost of Changes and Change Requests and any TI Costs in excess of to $50.00 per rentable square foot of the Second Expansion Premises (collectively, “Excess TI Costs”). Tenant shall deposit
with Landlord 50% of the Excess TI Costs as a condition precedent to Landlord’s obligation to complete the Tenant Improvements and the remaining 50% of the Excess TI Costs upon Substantial Completion of the Tenant Improvements. If Tenant fails
to deposit any Excess TI Costs with Landlord, Landlord shall have all of the rights and remedies set forth in the Lease for nonpayment of Rent (including, but not limited to, the right to interest at the Default Rate and the right to assess a late
charge). For purposes of any litigation instituted with regard to such amounts, those amounts will be deemed Rent under the Lease. 
 6.
Tenant Access. 
 (a) Tenant’s Access Rights. Landlord hereby agrees to permit Tenant access, at Tenant’s sole risk
and expense, to the Second Expansion Premises (i) 14 days prior to the Commencement Date to perform any work (“Tenant’s Work”) required by Tenant other than Landlord’s Work, provided that such Tenant’s Work is
coordinated with the TI Architect and the general contractor, and complies with the Lease and all other reasonable restrictions and conditions Landlord may impose, and (ii) prior to the completion of Landlord’s Work, to inspect and observe
work in process; all such access shall be during normal business hours or at such other times as are reasonably designated by Landlord. Any entry by Tenant shall comply with all established safety practices of Landlord’s contractor and Landlord
until completion of Landlord’s Work and acceptance thereof by Tenant. 
 (b) No Interference. Neither Tenant nor any Tenant
Party (as defined in the Lease) shall interfere with the performance of Landlord’s Work, nor with any inspections or issuance of final approvals by applicable Governmental Authorities, and upon any such interference, Landlord shall have the
right to exclude Tenant and any Tenant Party from the Second Expansion Premises until Substantial Completion of Landlord’s Work. 
 (c)
No Acceptance of Second Expansion Premises. The fact that Tenant may, with Landlord’s consent, enter into the Second Expansion Premises prior to the date Landlord’s Work is Substantially Complete for the purpose of performing
Tenant’s Work shall not be deemed an acceptance by Tenant of possession of the Second Expansion Premises, but in such event Tenant shall defend with counsel reasonably acceptable by Landlord, indemnify and hold Landlord harmless from and
against any loss of or damage to Tenant’s property, completed work, fixtures, equipment, materials or merchandise, and from liability for death of, or injury to, any person, caused by the act or omission of Tenant or any Tenant Party. 

7. Miscellaneous. 
 (a)
Consents. Whenever consent or approval of either party is required under this Second Expansion Premises Work Letter, that party shall not unreasonably withhold, condition or delay such consent or approval, unless expressly set forth herein to
the contrary. 
 (b) Modification. No modification, waiver or amendment of this Second Expansion Premises Work Letter or of any of
its conditions or provisions shall be binding upon Landlord or Tenant unless in writing signed by Landlord and Tenant. 

  
 B-5 

 Schedule 1 

Space Plan 
  

 

  
 B-6 

 Schedule 2 

Basis of Design 
  

			
	

	  	 Sage Therapeutics
 Expansion

 
 215 First Street

Cambridge, Massachusetts
  

	  

  

			
	Members of:	  	
		
	American Institute of Architects	  	
		
	Boston Society of Architects	  	2 May 2013
		
		  	BASIS OF DESIGN – ROOM DATA SHEETS
		
		  	 Open Office
 Conference Room 203, 205, &
207

 123 North Washington Street, Boston, Massachusetts 02114-2134    tel 617 227
7727    fax: 617 227 1870 

  
 B-7 

					
	 Sage Therapeutics – Expansion
 215
First Street, Floor 2
 Cambridge, Massachusetts
	  	ROOM DATA SHEET	  	Project No. 13116.11

  

			
	ROOM NAME/NUMBER:	  	 Open Office
 Room Nos. 201, 206, 208
(Huddle Area)

		
	FUNCTION:	  	General office work environment.
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	New broadloom carpet. New wall base – 4” high straight vinyl.
		
	 Wall Finish:
	  	Tenant standard eggshell finish, latex paint.
		
	 Ceiling:
	  	Open to structure above. No finished ceiling, except at Room 201 existing acoustic tile soffit area.
		
	 Door/Frame/Hardware:
	  	Entrance Doors: 3’-0” x 7’-0” solid core, clear finished, birch face veneers with full vision panel; tenant standard entrance lockset (Schlage).
		
	 Glazing:
	  	(4) 2’-9” tall x 5’-0” long, clear tempered glass wall panels with glazing channels tap & bottom and clear silicone joints, at 7’-8” above finished floor level.
		
	 Millwork:
	  	None.
		
	EQUIPMENT:	  	None.
		
	ENGINEERING SYSTEMS:	  	
		
	 Fire Protection:
	  	Re-work existing sprinkler layout to support new plan.
		
	 Plumbing:
	  	None.
		
	 HVAC:
	  	Base building system sized to adequately maintain a cooling temperature of an inside condition of 75 degrees F, dry bulb at 50% relative humidity; with outside condition of 91 degrees F and 74 degrees F wet bulb during summer and
72 degrees F dry bulb inside at zero degree dry bulb outside during the winter.
		
	 Electrical:
	  	
		
	 Lighting:
	  	Suspended, direct/indirect fluorescent fixtures; industry standard foot-candle level for office environments.
		
	 Power:
	  	Power feeds to systems furniture workstation clusters.
		
	 Communications:
	  	Multiple locations: single-gang wall box with pull string.

  

			
	 R E Dinneen Architects & Planners, Inc.

123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870
	  	10 December 2011

  
 B-8 

					
	 Sage Therapeutics – Expansion
 215
First Street, Floor 2
 Cambridge, Massachusetts
	  	ROOM DATA SHEET	  	Project No. 13116.11

  

			
	ROOM NAME/NUMBER:	  	 Conference Room
 Room No.
203

		
	FUNCTION:	  	Office support area used for meetings.
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	New broadloom carpet. New wall base – 4” high straight vinyl.
		
	 Wall Finish:
	  	Tenant standard eggshell finish, latex paint.
		
	 Ceiling:
	  	Existing to remain; No finished ceiling.
		
	 Door/Frame/Hardware:
	  	Existing to remain.
		
	 Millwork:
	  	None.
		
	EQUIPMENT:	  	None.
		
	ENGINEERING SYSTEMS:	  	
		
	 Fire protection:
	  	Existing to Remain
		
	 Plumbing:
	  	None.
		
	 HVAC:
	  	Base building system sized to adequately maintain a cooling temperature of an inside condition of 75 degrees F, dry bulb at 50% relative humidity; with outside condition of 91 degrees F and 74 degrees F wet bulb during summer and
72 degrees F dry bulb inside at zero degree dry bulb outside during the winter.
		
	 Electrical:
	  	
		
	 Fire Alarm:
	  	Update per conference room public use code requirements
		
	 Lighting:
	  	Existing to remain: surface mounted and suspended 2x4 parabolic fixtures.
		
	 Power:
	  	Existing to remain
		
	 Communications:
	  	One, single-gang wall box with pull string.

  

			
	 R E Dinneen Architects & Planners, Inc.

123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870
	  	10 December 2011

  
 B-9 

					
	 Sage Therapeutics – Expansion
 215
First Street, Floor 2
 Cambridge, Massachusetts
	  	ROOM DATA SHEET	  	Project No. 13116.11

  

			
	ROOM NAME/NUMBER:	  	 Conference Room
 Room No.
205

		
	FUNCTION:	  	Office support area used for meetings.
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	New broadloom carpet. New wall base – 4” high straight vinyl.
		
	 Wall Finish:
	  	Tenant standard eggshell finish, latex paint.
		
	 Ceiling:
	  	Open to structure above. No finished ceiling, except at elliptical-shaped acoustic ceiling tile “cloud”: Armstrong “Ultima” #194289, beveled, tegular edge, 24”x24”, white tile; Armstrong
“Suprafine XL”, 9/16” exposed tee, white grid.
		
	 Door/Frame/Hardware:
	  	Tenant standard door: 3’-0” x 7’-0” solid core, clear finished, birch face veneers and full vision panel; Tenant standard passage lockset (Schlage).
		
	 Glazing:
	  	2’-9” x 3’-4” long clear, tempered glass wall panel with glazing channels top & bottom and clear silicone joints, at 7’-8” above finished floor level.
		
	 Millwork:
	  	None.
		
	EQUIPMENT:	  	None.
		
	ENGINEERING SYSTEMS:	  	
		
	 Fire Protection:
	  	Re-work existing sprinkler layout to support new plan.
		
	 Plumbing:
	  	None.
		
	 HVAC:
	  	Base building system sized to adequately maintain a cooling temperature of an inside condition of 75 degrees F, dry bulb at 50% relative humidity; with outside condition of 91 degrees F and 74 degrees F wet bulb during summer and
72 degrees F dry bulb inside at zero degree dry bulb outside during the winter.
		
	 Electrical:
	  	
		
	 Fire Alarm:
	  	Provide fire alarm per code for conference room public use status
		
	 Lighting:
	  	Reuse existing suspended track lighting and recessed downlights; industry standard foot-candle level for office environments.
		
	 Power:
	  	Three duplex convenience power outlets.
		
	 Communications:
	  	Two, single-gang wall box with pull string.

  

			
	 R E Dinneen Architects & Planners, Inc.

123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870
	  	10 December 2011

  
 B-10 

					
	 Sage Therapeutics – Expansion
 215
First Street, Floor 2
 Cambridge, Massachusetts
	  	ROOM DATA SHEET	  	Project No. 13116.11

  

			
	ROOM NAME/NUMBER:	  	 Conference Room
 Room No.
207

		
	FUNCTION:	  	Office support area used for meetings.
		
	ARCHITECTURAL:	  	
		
	 Flooring:
	  	New broadloom carpet. New wall base – 4” high straight vinyl.
		
	 Wall Finish:
	  	Tenant standard eggshell finish, latex paint.
		
	 Ceiling:
	  	ACT system: Armstrong “Ultima” #194289, beveled, tegular edge, 24”x24”, white tile; Armstrong “Suprafine XL”, 9/16” exposed tee, white grid.
		
	 Door/Frame/Hardware:
	  	3’-0” x 8’-0” frameless, clear tempered glass door with hardware.
		
	 Glazing:
	  	(3) 8’-0” high x 3’-0” wide clear, tempered glass wall panels with glazing channels top & bottom and clear silicone joints; glass panels provided by tenant sub-leasee.
		
	 Millwork:
	  	None.
		
	EQUIPMENT:	  	None.
		
	ENGINEERING SYSTEMS:	  	
		
	 Fire Protection:
	  	Re-work existing sprinkler layout to support new plan.
		
	 Plumbing:
	  	None.
		
	 HVAC:
	  	Base building system sized to adequately maintain a cooling temperature of an inside condition of 75 degrees F, dry bulb at 50% relative humidity; with outside condition of 91 degrees F and 74 degrees F wet bulb during summer and
72 degrees F dry bulb inside at zero degree dry bulb outside during the winter.
		
	 Electrical:
	  	
		
	 Fire Alarm:
	  	Provide fire alarm per code for conference room public use status
		
	 Lighting:
	  	Reuse existing recessed, direct/indirect, basket, fluorescent fixtures; industry standard foot-candle level for office environments.
		
	 Power:
	  	Three duplex convenience power outlets.
		
	 Communications:
	  	Two, single-gang wall box with pull string.

  

			
	 R E Dinneen Architects & Planners, Inc.

123 North Washington Street, Boston, MA 02114 tel 617 227 7727 fax 617 227 1870
	  	10 December 2011

  
 B-11EX-10.7

 Exhibit 10.7 

Sage Therapeutics, Inc. 
 July 18,
2013 
 Jeffrey M. Jonas, M.D. 
 118 11th Street 

Del Mar, CA 92014 

	Re:	Employment by Sage Therapeutics, Inc. 

 Dear Jeff: 

Sage Therapeutics, Inc. (the “Company”) is pleased to confirm its revised offer to employ you as Chief Executive Officer (CEO). As CEO you will be
reporting to the Sage Therapeutics Board of Directors (BOD). 
 In the role of CEO, you will: 

 

	 	•	 	Work with the BOD and senior management to formulate and communicate a compelling vision and strategic direction for the company; evaluate alternative strategies; identify competitive issues; capitalize on platform
technology and develop and implement operating plans to achieve objectives. 

  

	 	•	 	Oversee all company activities to ensure SAGE meets its research, development, and financial milestones and all other objectives including clinical, regulatory, and business development. 

 

	 	•	 	Develop and maintain strategic partnerships with external companies, overseeing critical activities to ensure research and development commitments and related projects are fulfilled. 

 

	 	•	 	Serve as the primary spokesperson for company, establishing and communicating the company’s image, and enhancing its visibility among potential partners. 

 

	 	•	 	Build additional organizational experience to bear within the management team. Work with the Board and senior management team to manage uncertainty while maintaining an entrepreneurial environment. 

 

	 	•	 	Ensure that qualified research and development and managerial personnel are attracted and retained; manage performance by providing feedback, teaching and development opportunities 

 

	 	•	 	Represent SAGE in scientific conferences, presentations, Industry and Investment groups. 

  

	 	•	 	Build and maintain solid working relationships with key opinion leaders and investors. 

  

	 	•	 	Foster an internal atmosphere that supports individual accountability, transparency, open communication and respect to enable employees to focus on the Company’s mission. 

Your effective date of hire as a regular employee (the “Start Date”) will be August 12, 2013. 

Your compensation for this position will be at the rate of $425,000 per year, payable monthly in accordance with the Company’s normal pay schedule. For
the first several weeks of employment you 

 
will be working part-time, and be compensated at 50% of your normal pay rate until you are able to commence working full time, which will be no later than September 3, 2013. At that time
your salary will be increased to your full time rate. You will be eligible to participate each year in the Company’s annual target bonus pool plan of up to 40% of your base salary based upon achievement of both corporate and personal goals, as
agreed to between you and the BOD. You must be employed on the date on which the annual bonus is paid in order to receive it. 
 Sage Therapeutics
acknowledges that you currently reside in California and that you desire to accept this job as a full time position in Massachusetts. As a condition of your employment, you are expected to be on-site at the Company’s offices in Cambridge,
Massachusetts for 5 days per week. Since you are choosing not to relocate at this time but instead to commute. The Company will provide you with a sign- on bonus of $350,000 which will be paid to you in two installments. You will receive the first
payment of $225,000 during your first month of employment and it will be subject to customary deductions and withholdings as required by law. You will receive the second payment of $125,000 upon the first anniversary of your Start Date with Sage. In
addition, the Company will provide monthly temporary housing costs of up to $3,000 per month for the first six months of your employment with the Company. Should you voluntarily leave the Company, other than for death or disability, within 6 months
of receiving either the sign on bonus payments or the temporary housing payments, you will be obligated to return the gross amount of the payments to the company within 30 Days of your departure date. As a full time employee, you may participate in
any and all bonus and benefit programs that the Company establishes and makes available to its employees from time to time, provided you are eligible under (and subject to all provisions of the plan documents governing those programs). Current
benefits Include participation in a company sponsored health care plan, dental plan, short term disability Insurance, long term disability Insurance, 401k plan, 15 days of paid vacation and parking benefit. The Company, however, reserves the right
to modify, terminate, or replace its employee benefit plans and policies. 
 Subject to the approval of the Board of Directors of the Company (the
“Board”), in connection with the commencement of your employment, the Board will grant you an option to purchase 2,210,000 shares of the Company’s common stock (the “Option”). The Option will be granted following the
commencement of your employment. The exercise price of the Option will be at least equal to the fair market value of the Company’s common stock on the date of grant, and the Board of Directors may elect to seek a third party valuation of such
fair market value, which could delay the date that the Option is granted. The Option will be subject to the terms and conditions of the Company’s then- current stock option plan and form of stock option agreement. These options will vest as
follows: one quarter of the shares will vest on the first anniversary of the Start Date, and following that, 1/48th of the shares will vest on a monthly basis, In arrears. Vesting is contingent on your continued full-time employment with the
Company. 
 We have also discussed the possibility of implementing a more formal structure around guidelines for severance, change of control and
accelerated vesting in the event of a transaction or change of control. We agree that we will address in good faith and work thru new recommendations with the board as part of adopting an overall compensation philosophy for the company. 

You will perform your services from the Company’s offices in Cambridge, MA. It is understood that you are an “at-will” employee. You are not
being offered employment for a definite period of time, and either you or the Company may terminate the employment relationship at any time and for any reason, with or without cause or prior notice and without additional compensation to you. 

  
 -2- 

 Enclosed for your review is a “Non-Solicitation, Confidentiality and Assignment Agreement” (the
“Agreement”). 
 This offer of employment is conditioned on your willingness to sign and abide by the terms of the Agreement. You will be expected
to sign the Agreement before you report for work. 
 In making this offer, the Company understands, and in accepting it you represent that you are not under
any obligation to any former employer or any person or entity which would prevent, limit, or impair in any way the performance by you of your duties as an employee of the Company. 

The Immigration Reform and Control Act requires employers to verify the employment eligibility and identity of new employees. You will be required to complete
a Form I-9 which will be provided to you before the Start Date. Please bring the appropriate documents listed on that form with you when you report for work. We will not be able to employ you if you fail to comply with this requirement. Also, this
offer is subject to satisfactory reference checks if necessary. 
 This letter agreement and the Agreement referenced above constitute the complete
agreement between you and the Company, contain all of the terms of your employment with the Company and supersede any prior agreements, representations or understandings (whether written, oral or implied) between you and the Company. This letter
agreement may not be amended or modified, except by an express written agreement signed by both you and a duly authorized officer of the Company, although your job duties, title, reporting relationship, compensation and benefits may change from time
to time, at the Company’s option. 
 Please indicate your acceptance of this offer by signing and returning the enclosed copy of this letter no later
than 5pm ET on July 31, 2013. 
 Please indicate your acceptance of this offer by signing and returning a copy to Kimi Iguchi. We look
forward to your joining the Company and are pleased that you will be working with us. 
  

	
	Very truly yours,
	
	

	Kevin Starr
	President & Chief Executive Officer
	Sage Therapeutics, inc.

  

	
	Accepted and Agreed
	
	

	  
 Jeffrey M. Jonas, M.D.

	
	 7/31/13

	Date

  
 -3-

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