Document:

exv10w1

 

Exhibit 10.1

Portions of this agreement have been omitted and separately filed with the SEC with a request
for confidential treatment. The location of those omissions have been noted by [**].

FORM OF HENRY SCHEIN, INC. DISTRIBUTION AGREEMENT

          This Distribution Agreement (“Agreement”) is made and entered into as of July 29, 2005
(“Effective Date”) by and between Henry Schein, Inc. (“HSI”), on behalf of itself and its
wholly-owned U.S. subsidiaries (“Subsidiaries”) to participate under this Agreement (HSI and the
Subsidiaries, individually and collectively referred to herein as “Buyer”), having its principal
place of business at 135 Duryea Road, Melville, New York 11747, and Laserscope (“Seller”), having
its principal place of business at 3070 Orchard Drive, San Jose, California 95134.

          In consideration of the mutual covenants contained in this Agreement, and for other good and
valuable consideration, the sufficiency of which is acknowledged by both parties, the parties above
agree as follows:

1.    Appointment. Subject to the terms and conditions set forth herein, Seller appoints Buyer as its
nonexclusive national distributor for the resale of all products of Seller listed on Exhibit
A (the “Products”) to physicians and physician practices within the United States of America
including the District of Columbia, all 50 states, and all its territories and possessions (the
“Territory”), and Buyer accepts such appointment. Subject to the terms and conditions set forth
herein, such appointment shall be in effect for a period of three (3) years following the Effective
Date and shall continue automatically in effect for successive terms of three (3) years each until
terminated as described in Section 12 below. Buyer’s rights hereunder are non-assignable
(except in accordance with Section 14(d) below), non-licensable and non-sublicensable.

2.    Price. Seller shall sell the Products to Buyer in such quantities as Buyer may order and at the
[**] delivered to Buyer’s principal place of business. [**].

3.    Representations and Warranties.

          3.1    Seller hereby represents and warrants to Buyer that:

          (a)    All corporate actions on the part of Buyer, its respective officers, directors and
shareholders necessary for the authorization, execution and delivery of this Agreement and the
performance of all obligations of it hereunder have been taken or will be taken prior to the
execution hereof, and the Agreement, when executed and delivered by the parties, shall constitute
valid and legally binding obligations of the parties, enforceable against the respective parties in
accordance with its terms;

          (b)    Seller will convey to Buyer good title to the Products, free and clear of all security
interests, liens or other encumbrances of any kind or character;

          (c)    Seller has manufactured, packaged and is selling the Products to Buyer in compliance with
all applicable federal, state, and local laws, rules and regulations (including, without
limitation, applicable laws regarding labeling, environmental protection, shipping, labor, customs
regulations, country of origin requirements and the Foreign Corrupt Practices Act, and any
applicable ISO standards) and shall not violate any trademark, trade dress, trade name, trade
secret, patent, or copyright. None of the Products when disposed of will constitute “hazardous
waste” under regulations (the “Regulations”) promulgated by the Environmental Protection Agency
under Subpart C of the Solid Waste Disposal Act, as amended by the Resource Conservation and
Recovery Act of 1976, as amended, or if any of the Products when disposed of will constitute
“hazardous waste” under the Regulations, Seller has notified Buyer as to the identity of such
Products;

	 	(d)	 	[**];

	 	(e)	 	[**];

	 	(f)	 	[**]; and

	 	(g)	 	[**].

	 	3.2	 	Buyer represents and warrants to Seller that:

[**]
Confidential or proprietary information redacted.

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          (a)    All corporate actions on the part of Seller, its respective officers, directors and
shareholders necessary for the authorization, execution and delivery of this Agreement and the
performance of all obligations of it hereunder have been taken or will be taken prior to the
execution hereof, and the Agreement, when executed and delivered by the parties, shall constitute
valid and legally binding obligations of the parties, enforceable against the respective parties in
accordance with its terms.

          (b)    Buyer has been duly registered and organized in accordance with any and all applicable
laws, has received any and all necessary governmental authorizations to enter into and perform its
obligations under this Agreement, and that its entry into and performance under this Agreement will
not violate applicable laws.

          (c)    Buyer is duly registered with all necessary tax authorities and is in compliance with all
payment obligations, including tax obligations, in accordance with applicable laws.

          (d)    Buyer’s bank accounts have been established and operated in accordance with applicable
laws. All transactions of Buyer required to be carried out through authorized banks have been so
carried out. Buyer has not and will not breach any currency regulation or currency control
legislation, or any bank secrecy act, rules or regulations.

4.   Duties of the Parties

          4.1.   Seller’s Duties. Seller hereby agrees, as long as this Agreement is in effect, as
follows:

          (a)    [**];

          (b)    During the term of this Agreement, Seller shall maintain commercial general liability
insurance with minimum limits of coverage of [**]. The policy shall be an occurrence-based and not
claims-made policy, except that Seller may provide a claims-made policy based upon Seller’s
representation and warranty as follows: Seller hereby represents and warrants that [**] it shall
continue to renew its product liability coverage for the term of this Agreement [**]. In the event
that Buyer determines that Seller is not complying with its insurance obligations hereunder, Buyer
may purchase and/or renew such insurance coverage necessary for Seller to comply with Seller’s
insurance obligations hereunder. Seller shall reimburse Buyer for such costs incurred, and Buyer
may offset the cost of such insurance against any amounts it owes Seller. This occurrence-based or
claims-made coverage shall insure against [**]. Upon execution of this Agreement, Seller shall
provide Buyer with a certificate of insurance [**] with respect to all forms of coverage available
to Seller pursuant to its policy or policies of general liability insurance, including but not
limited to the forms of coverage identified above, and with the limits of liability specified
above. Seller shall furnish to Buyer a certificate of insurance evidencing such coverage,
certifying that the policy or policies of insurance described therein will not be altered, modified
or canceled in any way that adversely affects Buyer’s interest hereunder without giving Buyer [**]
written notice;

          (c)    Subject to Section 8 hereof, Seller shall promptly satisfy Buyer’s orders for the
Products, to enable Buyer to maintain a supply of the Products sufficient to provide adequate and
timely service to Buyer’s customers; and

          (d)    Seller will provide notice to Buyer of any regulatory action related to its operations
that is likely to have a material adverse effect on Seller’s ability to comply or perform under
this Agreement and Seller shall be responsible, if required by applicable Legal Requirements, for
notifying the appropriate federal, state and local authorities of any customer complaints or other
occurrences regarding the Products, evaluating all complaints and responding to Buyer in writing on
the resolution of any complaints from Buyer for its customers.

          4.2    Buyer’s Duties. Buyer hereby agrees, as long as this Agreement is in effect, as follows:

          (a)    Buyer shall [**] promote the products and to satisfy customer demand for the Products;

          (b)    Buyer, at least [**] each year, shall provide reasonable time for certain of its sales
personnel to meet with a sales representative of Seller;

          (c)    Buyer shall actively promote, distribute and sell Products only within the Territory, and
neither Buyer nor its Subsidiaries shall promote or solicit orders for Product or sell, offer to
sell or otherwise distribute Product outside the Territory, or where they ought reasonably to be
aware that the ultimate destination for Product is outside the Territory. Buyer and its
Subsidiaries and their respective employees and agents shall not promote Product for any
indications not approved for such Product by the United

[**]
Confidential or proprietary information redacted.

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States Food and Drug Administration. Buyer shall forward to Seller all inquiries relating to
Products from customers or potential customers outside the Territory;

          (d)    Buyer shall not make any alterations or knowingly permit any alterations to be made to
Product (including without limitation labeling, instructions or equipment) without Seller’s express
written consent, which consent may be withheld in Seller’s sole discretion;

          (e)    Buyer shall, and shall require its Subsidiaries to, conduct all promotion, marketing,
distribution and sale of Products, including, without limitation, handling, inventory and storage
of Product, in compliance with all applicable laws and regulations and all applicable rules and
requirements of Seller;

          (f)    Buyer shall, at its expense, obtain and maintain in full force and effect throughout the
term of this Agreement any and all licenses and approvals necessary for its distribution and sale
of Product in the Territory, in full compliance with all applicable laws and regulations. Buyer
shall not use any advertisement or marketing material on, with respect to or relating to any
Product unless such advertisement or marketing material has been provided by Seller or has first
been submitted to and approved by Seller in advance in writing;

          (g)    Buyer shall provide notice to Seller of any regulatory action related to its operations
that is likely to have a material adverse effect on Buyer’s ability to comply or perform under this
Agreement;

          (h)    Buyer shall not, without Seller’s prior written consent, appoint any subdistributors or
agents to promote and/or distribute Products. Further, notwithstanding any such appointment, or
Seller’s approval thereof, Buyer shall at all times remain fully liable for performance of its
subdistributors and/or agents and Buyer hereby agrees to indemnify and hold harmless Seller from
all damages, losses, costs or expenses arising in any manner from any act or omission on the part
of its subdistributors or agents;

          (i)    Buyer shall promptly furnish Seller with copies of any correspondence or other
communications from its customers with respect to the use of the Products, Product applications,
suggestions for modification of or improvement to the Products, and other pertinent information;
and

          (j)    The Products are offered for sale and manufactured by Seller. Such sale does not convey
or license to Buyer the right to, and Buyer shall not, directly or indirectly, manufacture,
duplicate or otherwise copy or reproduce any of the Products or any portion thereof. In addition,
Buyer shall not, directly or indirectly, reverse engineer any of the Products or any portion
thereof, including without limitation, any designs, assemblies, lasers, fiber optics, circuits,
firmware or software contained therein. Buyer will take appropriate steps to inform its customers
of and assure compliance with these restrictions.

          (k)    As a condition to amendment of the definition of “Products” pursuant hereto, Buyer shall
take such actions as Seller may deem necessary or appropriate to ensure end user compliance with
the Seller’s policies, procedures and restrictions of use of such new Products.

4.3 [**].

4.4 [**].

5.         Shipment, Risk of Loss and Title. All shipments of Products (other than drop shipments directly
from Seller to Buyer’s customers) shall be shipped by Seller [**], with risk of loss and title to
Products to pass to Buyer upon [**], unless otherwise specified in an agreement signed by the
parties hereto. Drop shipments of Products directly from Seller to Buyer’s customers shall be
shipped by Seller [**], with risk of loss and title to Products to pass to Buyer [**]. [**].

6.         Defective Products. In the event that any of the Products when delivered to recipient do not
conform to Seller’s warranty or are otherwise defective or damaged as delivered to the recipient,
recipient shall notify Seller as to such condition promptly upon recipient’s discovery of same, and
shall provide Seller with a reasonable opportunity to inspect such Products. Seller shall, in its
sole discretion, either repair or replace or shall refund the invoice price associated with, any
Products which do not conform to Seller’s warranty or are otherwise defective or damaged as
delivered to the recipient, upon the return of such Products to Seller. All transportation charges
for the return of such Products shall be paid by [**].

7.         Returned Products

[**] Confidential or proprietary information redacted.

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          7.1         Pre-authorized Returns. In the event that (i) Seller fails to correctly fill any of
Buyer’s orders for Products, or (ii) Products are discontinued and unsalable, or (iii) the Products
are subject to an injunction or governmental order or regulation which suspends the marketability
of the Products, or (iv) the Products are subject to expiration dating and have a remaining “shelf
life” of less than [**] (unless otherwise agreed to by the parties and attached as an Exhibit
hereto) of their total “shelf life,” or (v) Products are returnable without authorization pursuant
to any written agreement between Buyer and Seller, then Buyer shall have the right to return the
affected Products to Seller and to receive a refund of the invoice price for such Products. Unless
otherwise agreed, Buyer shall return all Products to Seller by Seller’s catalog and/or lot numbers.
All transportation charges resulting from the return of Products pursuant to this Subsection
7.1 shall be paid [**].

          7.2         Other Returns. For specific Products purchased by and shipped directly to Buyer pursuant
to a purchase order indicating that such Products are not being purchased for resale to a specified
third party (i.e. such Products are being purchased for Buyer’s inventory), Buyer shall have the
right to return for its convenience any such specific Product to Seller within [**] of its delivery
to Buyer, provided such Product is identified by applicable serial number and is in new and
unopened condition (with sufficient expiration dating, if applicable). For any Products shipped
directly to Buyer for consignment, Buyer shall have the right to return a number of Products agreed
in writing in advance by Seller and Buyer that are in new and unopened condition (with sufficient
expiration dating, if applicable) to Seller [**]. Seller shall provide a return authorization to
Buyer for such returns pursuant to this Subsection 7.2 within [**] of a request for return
authorization. Seller shall credit Buyer, within [**] from the date of the return, the amount of
the invoice price associated with all Products returned pursuant to this Subsection 7.2. [**]
shall pay all transportation charges associated with the return of such Products to Seller pursuant
to Subsection 7.2. [**].

8.         Excusable Delays. Seller shall not be charged with any liability for delay or non-delivery of
the Products when due to delays of suppliers, acts of God or the public enemy, compliance in good
faith with any applicable foreign or domestic governmental regulation or order whether or not
proven to be valid, riots, labor disputes, unusually severe weather or any other cause beyond the
reasonable control of Seller. Seller shall give Buyer written notification of any material or
indefinite delay due to such causes. Within [**] after receipt of any such notification from
Seller, Buyer shall instruct Seller in writing that the portion of Buyer’s order affected by such
delay is either (i) affirmed, and the time for performance extended for as many days as such causes
actually retard deliveries; or (ii) terminated.

9.         Taxes. Buyer is responsible for all taxes (excluding Seller’s income taxes) arising from
Seller’s sale of the Products to Buyer. If Buyer claims exemption from any taxes related to such
sales, Buyer shall supply such documentation as Seller is required to collect to support such
exemption. Seller shall include amounts on its invoices for any taxes related to such sales that
it is required to collect under applicable laws and will remit them to the appropriate governmental
agencies. Buyer agrees to pay for any taxes related to such sales that are billed on Seller’s
invoices. Buyer is solely responsible for the payment of any other taxes arising from its purchase
of the Products. Buyer agrees to pay Seller for any additional taxes related to such sales
(excluding Seller’s income taxes) that are assessed by governmental agencies.

10.         Trademarks and Other Intellectual Property: Use of Buyer’s Name.

          10.1         All Seller trademarks (the “Trademarks”) and derivatives thereof relating to Products,
and all technology and other Intellectual Property (as defined below), are the sole and exclusive
property of Seller. Seller hereby grants Buyer permission to use the Trademarks in the Territory
for the limited purpose of Buyer performing its rights and obligations under this Agreement during
the Term. Products shall be promoted, sold and distributed only under the Trademarks. Buyer shall
ensure that each use of and reference to any of the Trademarks (by Buyer or its Subsidiaries) is
accompanied by a statement that it is a registered trademark of Seller. Seller may, in its sole
discretion, modify or discontinue the use of any trademark and/or use one or more additional or
substitute marks or names, and Buyer and its Subsidiaries shall be obligated to do the same in
connection with marketing and selling Products.

          For purposes of this Agreement, “Intellectual Property” means all of Seller’s worldwide
patents, software, Trademarks, trade names, inventions, copyrights, regulatory approvals, know-how,
Trade Secrets, and all the goodwill associated therewith, and all other intellectual property
rights, in existence as of the effective date of this Agreement or hereafter developed or acquired
by Seller, relating to the design, manufacture, operation or maintenance of the Products.

          For purposes of this Agreement, “Trade Secrets” means any formula, pattern, device, or
compilation of information which is used in Seller’s business and which provides competitive
advantage to Seller and which is not known or used by Seller’s competitors or the public. This
term includes, but is not limited to, formulas, compounds, manufacturing or servicing processes,
methods for treating or preserving materials, patterns for the design or operation of machines and
devices, materials filed with governmental agencies, regulatory submission with government
agencies, customer lists, and information relating to the marketing of Seller’s products and
services.

[**] Confidential or proprietary information redacted.

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          10.2         Neither Buyer nor its Subsidiaries shall: (i) use the Trademarks in any way that might
prejudice their distinctiveness or validity or the goodwill of Seller therein; (ii) use any
Trademark in connection with the sale of any other product, or use any other trademark other than
the Trademarks, in connection with Products; (iii) modify Products or its labeling or packaging or
alter, obscure, or remove the Trademarks, indication of the source of origin, other means of
identification or other markings used on or in relation to Product; or (iv) at any time during or
after the term of this Agreement challenge or assist others to challenge the Trademarks or the
registration thereof, or use or make any application for registration in the Territory of any
trademarks or tradenames so resembling any trademark or tradename of Seller (including, without
limitation, any Trademark) as to be likely to cause confusion or deception. [**].

          10.3         The Product(s) may contain software which is proprietary to Seller. Seller at all times
retains ownership of and title to the software supplied with a Product, and to the Trade Secrets
(as defined herein) embodied in such software. Subject to the terms of this Agreement, Seller
grants Buyer a non-exclusive license to use such software in the form(s) and on the medium(s) which
is/are delivered. The use of these programs are for the purpose of operating the Product(s) in
accordance with the instructions in the Operator’s Manual(s) and for no other purposes. Buyer may
not reverse assemble or reverse compile such software, nor make any copy of such software or apply
any techniques to derive the Trade Secrets embodied therein. No licenses are granted by Seller to
Buyer under this Agreement, whether by implication, estoppel or otherwise, except as expressly set
forth herein.

          104         In the event Buyer becomes aware of any infringement of, or threatened or suspected
infringement of, or challenge to any Trademark or other Intellectual Property of Seller, Buyer
shall notify Seller immediately. Seller shall investigate any alleged violation and may take legal
action as it deems appropriate to resolve the issue and to prevent others from infringing on its
Intellectual Property rights within the Territory. At Seller’s reasonable request, and at Seller’s
expense, Buyer shall cooperate with and assist Seller in connection with any such infringement.

          10.5         Except only for the limited rights as expressly permitted hereunder, and then only as
necessary for the proper performance of Buyer’s obligations hereunder, Buyer hereby acknowledges
that it shall acquire no rights, express or implied, in respect of any of Seller’s Intellectual
Property, including the tradenames or trademarks of Seller (including but not limited to the
Trademarks) or of the goodwill associated therewith and that all such rights and goodwill are, and
shall remain, vested in Seller.

          10.6         Buyer will not do, nor will Buyer allow or authorize its Subsidiaries or anyone else to
do, any act which would or might invalidate or be inconsistent with the Intellectual Property of
Seller (including the Trademarks), and Buyer shall not omit or allow or authorize anyone to omit to
do any act which, by its omission, would have that effect.

11.         [**].

12.         Termination.

          12.1 Either party hereto may terminate this Agreement, as follows: (1) for cause, upon [**]
written notice to the other party, in the event that the other party: (i) shall fail to perform
any of the obligations in this Agreement (unless such failure is caused by a material act or
omission by the other party) and such failure shall continue for a period of [**] after written
notice thereof; or (ii) shall become insolvent, file a voluntary petition under any law relating to
bankruptcy or insolvency, or shall become unable to pay its debt when due; or (2) without cause, by
giving the other party [**] advance written notice thereof.

          12.2         Upon expiration or termination of this Agreement, Buyer will return to Seller, at [**]
expense (1) all sales promotion materials and aids provided hereunder and (2) any tools or
equipment loaned or furnished to Buyer pursuant to this Agreement. Buyer also shall furnish Seller
with the names and addresses of (1) customers that have purchased or otherwise acquired Products
from Buyer, and (2) any persons or entities that have assisted in the sale or distribution of the
Products.

          12.3         The provisions of this Agreement expressly concerning obligations of records and payment,
confidentiality and non-disclosure, indemnification, termination, and provisions concerning Product
warranties, no right to manufacture or copy, no reverse engineering, intellectual property rights,
and limitations of liability, shall survive any expiration or termination of this Agreement for any
reason.

          12.4         IN THE EVENT OF TERMINATION BY EITHER PARTY IN ACCORDANCE WITH ANY OF THE PROVISIONS OF
THIS AGREEMENT AND SUBJECT TO SECTION 13.4, NEITHER PARTY SHALL BE LIABLE TO THE OTHER, AND EACH
PARTY HEREBY EXPRESSLY WAIVES ALL RIGHTS, BECAUSE OF SUCH TERMINATION, FOR COMPENSATION,
REIMBURSEMENT OR DAMAGES ON ACCOUNT OF THE LOSS OF PROSPECTIVE PROFITS OR ANTICIPATED SALES OR ON
ACCOUNT OF EXPENDITURES, INVENTORY, INVESTMENTS, LEASES OR

[**] Confidential or proprietary information redacted.

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COMMITMENTS IN CONNECTION WITH THE BUSINESS OR GOODWILL OF SELLER OR BUYER. TERMINATION SHALL
NOT, HOWEVER, RELIEVE EITHER PARTY OF OBLIGATIONS INCURRED PRIOR TO THE TERMINATION.

13. Confidentiality and Non-Disclosure.

          13.1         As used herein, “Confidential Information” shall mean any information relating to the
business of the disclosing party which the disclosing party has marked as “confidential,”
designated as confidential in this Agreement or, in the case of oral information, has identified as
confidential in writing to the receiving party within thirty (30) days of disclosure.
Notwithstanding the foregoing, information which is orally or visually disclosed to the receiving
party by the disclosing party, or is disclosed in writing without an appropriate letter,
proprietary stamp or legend, shall constitute Confidential Information if it would be apparent to a
reasonable person, familiar with the disclosing party’s business and the industry in which it
operates, that such information is of a confidential or proprietary nature. The pricing and
pricing terms in this Agreement and any other agreement between Seller and Buyer shall be deemed
“Confidential Information.” Notwithstanding anything to the contrary in this Section 13,
Confidential Information shall not include: information that is approved for public release by the
written authorization of the disclosing party; information that was disclosed to the receiving
party by a third party having the legal right to make such disclosure, or which the receiving party
can establish was in its lawful possession prior to its receipt thereof from the disclosing party;
information that is in the public domain prior to the receiving party’s receipt thereof from the
disclosing party, or which subsequently becomes a part of the public domain other than by the
receiving party’s negligence or wrongful act; such information required to be disclosed by law,
governmental or regulatory request or legal process; or information that the receiving party can
establish was independently developed without breach of this Agreement or use of Confidential
Information.

          13.2         Non-disclosure. Except to the extent permitted under this Section 13, each
party: (i) shall not disclose Confidential Information of the other party to any third party
without first obtaining the express written permission of the disclosing party; (ii) shall use
Confidential Information of the other party only as is necessary to fulfill its obligations
pursuant to this Agreement; (iii) shall limit such disclosure to any of its officers, employees or
agents on a need-to-know basis for purposes of fulfilling its obligations under this Agreement,
provided that any such non-employees of recipient are bound by this Agreement or confidentiality
obligations substantially similar to those set forth in this Agreement; and (iv) may disclose this
agreement, any amendments, and such Confidential Information to its outside attorneys and
independent accountants, on a need to know basis. Notwithstanding the foregoing, Confidential
Information of the other party may be disclosed pursuant to a subpoena or court order, provided
that the receiving party gives prompt notice to the disclosing party that it intends to make such
disclosure so that the other party can take any appropriate steps it deems necessary to limit the
extent of such disclosure or to seek protection of such disclosure.

          13.3         Nothing in this Section shall impair either party’s compliance with any requirements of
the Securities and Exchange Commission or the national securities exchange or other stock market on
which such Party’s securities are traded. In connection with any filing by either Party of a copy
of this Agreement with the Securities and Exchange Commission (or the national securities exchange
or other stock market on which such Party’s securities are traded), the filing party shall endeavor
to obtain confidential treatment of economic and trade secret information.

          13.4         Effect of Termination or Expiration. Upon termination or expiration of this Agreement,
each party shall return to the other party or destroy any Confidential Information of the other
party and provide a written verification of such return or destruction. Each party’s obligation to
maintain the confidentiality of Confidential Information shall survive [**] following termination
or expiration of this Agreement.

14.      Miscellaneous.

          (a)         The relationship between the parties hereto shall be that of independent contracting
parties. Under no circumstances will either party hereto act or attempt to act, or represent
itself, directly or indirectly, as an agent of the other party hereto except as expressly permitted
herein. All sales and other agreements between Buyer and its customers are Buyer’s exclusive
responsibility and do not affect Buyer’s obligations under this Agreement. Buyer shall assume sole
responsibility for all claims, damages, obligations, injuries and liabilities, including
non-compliance with local regulatory requirements, arising from its acts or omissions or the acts
or omissions of its employees, servants, agents clients, or representatives.

          (b)         This Agreement and the transactions provided for herein are to be governed by and
construed in accordance with the laws of the State of California without regard to laws dictating
choice of law or resolving conflicts of laws. The parties hereby agree that any action that arises
from this agreement shall be subject to the exclusive jurisdiction of the courts within Santa Clara
County in the State of California.

[**] Confidential or proprietary information redacted.

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          (c)         This Agreement embodies the entire agreement and understanding between the parties hereto
and supersedes all prior agreements and understandings relating to the subject matter hereof. No
subsequently delivered invoice, purchase order, acknowledgment, confirmation, standard terms and
conditions or similar document, whether submitted in writing, electronically, or via fax,
containing terms inconsistent herewith shall be effective to amend or modify this Agreement unless
such document expressly states the intention to do so and is signed by both parties hereto. The
failure on the part of either party to exercise or enforce any right under this Agreement shall not
be deemed to be a waiver of any such right or similar subsequent rights or operate to bar the
exercise of enforcement thereof at anytime or times thereafter.

          (d)         Neither party may assign this Agreement or any of its rights, duties or obligations
hereunder without the prior written consent of the other party, which consent shall not be
unreasonably withheld or delayed; provided that either party may assign this Agreement and its
rights, duties and obligations hereunder to a successor entity in connection with the sale of all
or substantially all of its assets or the merger, acquisition or other consolidation of such party
with or into another party, and the other party’s consent shall not be required hereunder in
connection therewith. This Agreement shall be binding upon and inure to the benefit of the
permitted assigns and successors in interest of the respective parties.

          (e)         All notices, requests, demands and other communications called for or contemplated herein
shall be in writing and sent by commercial courier or commercial overnight delivery service (e.g.,
FedEx, DHL) , to the address shown on the first page of this Agreement, or at such other address,
as either party may designate in writing. A notice shall be deemed delivered upon the date of its
actual receipt.

          (f)         All sales by Buyer shall be exclusive of Seller’s service contract revenue. All service
contract revenues shall be handled directly through the Seller’s organization.

          (g)         Neither party shall provide any compensation or other benefit to the other party’s
employees without the prior written consent of such other party and each party hereto agrees to
promptly disclose any financial relationships between it and any of the other party’s employees
which may give rise to a conflict of interest between such employee and his employer.

          (h)         No right, express or implied, is granted to Seller hereunder to use in any manner any
name, trade name, trademark or service mark of Buyer, and no right, express or implied, is granted
to Buyer hereunder to use in any manner any name, trade name, trademark or service mark of Seller.

          (i)         If any court or other competent authority holds any provision of this Agreement to be void
or unenforceable in whole or part, this Agreement shall continue to be valid as to the other
provisions and the remainder of the affected provision.

          (j)         This Agreement may be executed in two or more counterparts, each of which shall be deemed
an original and all of which together shall constitute one and the same instrument.

          IN WITNESS WHEREOF, the parties hereto have duly executed this Agreement as of the day and
year first above written.

	 	 	 
	(“Buyer”)	 	
(“Seller”)
	HENRY SCHEIN, INC	 	
LASERSCOPE
	 
	By:

 

Its:
 
	 	
By:

 

Its:  President and Chief Executive Officer
 

	Date:

 
	 	
Date:

 

[**] Confidential or proprietary information redacted.

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Exhibit A

Products

[**]

[**] Confidential or proprietary information redacted.

8exv4w4

 

Exhibit 4.4

THESE SECURITIES AND THE SECURITIES FOR WHICH THESE SECURITIES ARE EXERCISABLE HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “SECURITIES ACT”), OR ANY STATE
SECURITIES LAWS AND ARE BEING OFFERED AND SOLD ONLY PURSUANT TO OFFERS AND SALES THAT OCCUR OUTSIDE
THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE SECURITIES ACT. THESE SECURITIES
AND THE SECURITIES FOR WHICH THESE SECURITIES ARE EXERCISABLE MAY NOT BE RE-OFFERED, SOLD,
ASSIGNED, TRANSFERRED, PLEDGED, ENCUMBERED OR OTHERWISE DISPOSED OF IN THE ABSENCE OF SUCH
REGISTRATION OR UNLESS THE TRANSACTION IS EXEMPT FROM, OR NOT SUBJECT TO, REGISTRATION. THE HOLDER
OF THESE SECURITIES BY ITS ACCEPTANCE HEREOF AGREES TO OFFER, SELL OR OTHERWISE TRANSFER THESE
SECURITIES AND THE SECURITIES FOR WHICH THESE SECURITIES ARE EXERCISABLE PRIOR TO THE DATE THAT IS
TWO YEARS AFTER THE LATER OF THE ORIGINAL ISSUE DATE HEREOF AND THE LAST DATE ON WHICH THE COMPANY
OR ANY AFFILIATE OF THE COMPANY WAS THE OWNER OF THESE SECURITIES AND THE SECURITIES FOR WHICH
THESE SECURITIES ARE EXERCISABLE, ONLY (A) TO THE COMPANY, (B) PURSUANT TO A REGISTRATION STATEMENT
WHICH HAS BEEN DECLARED EFFECTIVE UNDER THE SECURITIES ACT, (C) PURSUANT TO OFFERS AND SALES TO
NON-U.S. PERSONS THAT OCCUR OUTSIDE THE UNITED STATES WITHIN THE MEANING OF REGULATION S UNDER THE
SECURITIES ACT IN A TRANSACTION MEETING THE REQUIREMENTS OF RULE 904 UNDER THE SECURITIES ACT, OR
(D) PURSUANT TO ANOTHER AVAILABLE EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE SECURITIES
ACT, SUBJECT TO THE COMPANY’S RIGHT PRIOR TO ANY OFFER, SALE OR TRANSFER PURSUANT TO CLAUSE (C) OR
(D) TO REQUIRE THE DELIVERY OF AN OPINION OF COUNSEL, CERTIFICATES AND/OR OTHER INFORMATION
REASONABLY SATISFACTORY TO THE COMPANY. THE HOLDER OF THESE SECURITIES BY ITS ACCEPTANCE HEREOF
FURTHER AGREES NOT TO ENGAGE IN HEDGING TRANSACTIONS INVOLVING THESE SECURITIES AND THE SECURITIES
FOR WHICH THESE SECURITIES ARE EXERCISABLE UNLESS SUCH TRANSACTIONS MEET THE REQUIREMENTS OF AND
COMPLY WITH THE SECURITIES ACT.

INTROGEN THERAPEUTICS, INC.

STOCK PURCHASE WARRANT

	 	 	 	 	 
	Warrant No. [___]
	 	 
	 	Dated: [___]

     Introgen Therapeutics, Inc., a Delaware corporation (the “Company”), hereby certifies
that, for value received, [___] or its registered assigns (the “Holder”), is
entitled to purchase from the Company up to a total of [___] shares of common stock, $0.001
par value per share (the “Common Stock”), of the Company (each such share, a “Warrant
Share” and all such shares, the “Warrant Shares”) at an exercise price equal to $[___]
per share (as adjusted from time to time as provided in Section 8, the “Exercise
Price”), at any time and from time to time from and after the second anniversary of the date
hereof until the earlier to occur of (i) December [___], 2009 and (ii) immediately prior to a Change
of Control, as such term is defined below (such earlier date, the “Expiration Date”), and
subject to the following terms and conditions. This Warrant (this “Warrant”) is issued
pursuant to that certain Placement Agent Agreement dated December 6, 2004, by and among the Company
and Mulier Capital Limited (the “Placement Agent Agreement”). For purposes of this
Warrant, a “Change of Control” shall mean (i) the merger or consolidation of the Company
with or into another person in which the Company is not the surviving entity, (ii) the sale of all
or substantially all of the Company’s assets in one or a series of related transactions or (iii) a
change in ownership of the Company’s voting securities, other than a transaction or series of
transactions in which the holders of the Company’s voting securities outstanding immediately prior
to such transaction continue to retain (either by such voting securities remaining outstanding or
by

 

such voting securities being converted into voting securities of the surviving entity) at
least fifty percent (50%) of the total voting power represented by the voting securities of the
Company or such surviving entity outstanding immediately after such transaction or series of
transactions.

     1. Definitions. In addition to the terms defined elsewhere in this Warrant,
capitalized terms that are not otherwise defined herein have the meanings given to such terms in
the Placement Agent Agreement.

     2. Registration of Warrant. The Company shall register this Warrant, upon records to
be maintained by the Company for that purpose (the “Warrant Register”), in the name of the
record Holder hereof from time to time. The Company may deem and treat the registered Holder of
this Warrant as the absolute owner hereof for the purpose of any exercise hereof or any
distribution to the Holder, and for all other purposes, absent actual notice to the contrary.

     3. Registration of Transfers. The Company shall register the transfer of any portion
of this Warrant in the Warrant Register, upon surrender of this Warrant, with the Form of
Assignment attached hereto duly completed and signed, to the Transfer Agent or to the Company at
its address specified herein. Upon any such registration or transfer, a new warrant to purchase
Common Stock, in substantially the form of this Warrant (any such new warrant, a “New
Warrant”), evidencing the portion of this Warrant so transferred shall be issued to the
transferee and a New Warrant evidencing the remaining portion of this Warrant not so transferred,
if any, shall be issued to the transferring Holder. The acceptance of the New Warrant by the
transferee thereof shall be deemed the acceptance by such transferee of all of the rights and
obligations of a holder of a Warrant.

     4. Exercise and Duration of Warrants.

          (a) This Warrant shall be exercisable by the registered Holder at any time and from time to
time on or after the second anniversary of the date hereof until the Expiration Date.
Notwithstanding the foregoing, in the event a Change of Control is consummated before the second
anniversary of the date hereof, then the Warrant shall be exercisable immediately prior to the
closing of such Change of Control. At 5:00 P.M., Austin, Texas time, on the Expiration Date, the
portion of this Warrant not exercised prior thereto shall be and become void and of no value. If
the Company intends to consummate a Change of Control, then the Company shall deliver to the Holder
a notice describing the material terms and conditions of such transaction, at least ten (10)
calendar days prior the consummation of such Change of Control; provided, however, that the failure
to deliver such notice or any defect therein shall not affect the validity of the Change of
Control.

          (b) A Holder may exercise this Warrant by delivering to the Company (i) an Exercise Notice, in
the form attached hereto, appropriately completed and duly signed, and (ii) payment of the Exercise
Price for the number of Warrant Shares as to which this Warrant is being exercised (which may take
the form of a “cashless exercise” if so indicated in the Exercise Notice), and the date such items
are delivered to the Company (as determined in accordance with the notice provisions hereof) is an
“Exercise Date.” Execution and delivery of the Exercise Notice shall have the same effect
as cancellation of the original Warrant and issuance of a New Warrant evidencing the right to
purchase the remaining number of Warrant Shares.

-2-

 

     5. Delivery of Warrant Shares.

          (a) Upon exercise of this Warrant and surrender of the original Warrant at the offices of the
Company, the Company shall promptly (but in no event later than three business days after the
Exercise Date) issue or cause to be issued and cause to be delivered to or upon the written order
of the Holder and in such name or names as the Holder may designate, a certificate for the Warrant
Shares issuable upon such exercise. The Holder, or any Person so designated by the Holder to
receive Warrant Shares, shall be deemed to have become holder of record of such Warrant Shares as
of the Exercise Date.

          (b) This Warrant is exercisable, either in its entirety or, from time to time, for a portion
of the number of Warrant Shares. Upon surrender of this Warrant following one or more partial
exercises, the Company shall issue or cause to be issued, at its expense, a New Warrant evidencing
the right to purchase the remaining number of Warrant Shares.

     6. Charges, Taxes and Expenses. Issuance of certificates for shares of Common Stock
upon exercise of this Warrant shall be made without charge to the Holder for any United States
issue or transfer tax, transfer agent fee or other incidental United States tax or expense in
respect of the issuance of such certificates, all of which taxes and expenses shall be paid by the
Company; provided, however, that the Company shall not be required to pay any income or value added
tax which may be payable in respect of the issuance of the Warrants or any Warrant Shares, or in
respect of any transfer involved in the registration of any certificates for Warrant Shares or
Warrants in a name other than that of the Holder or an Affiliate thereof. The Holder shall be
responsible for all other tax liability that may arise as a result of receiving, holding or
transferring this Warrant or receiving Warrant Shares upon exercise hereof.

     7. Reservation of Warrant Shares. The Company covenants that it will at all times
reserve and keep available out of the aggregate of its authorized but unissued and otherwise
unreserved Common Stock, solely for the purpose of enabling it to issue Warrant Shares upon
exercise of this Warrant as herein provided, the number of Warrant Shares which are then issuable
and deliverable upon the exercise of this entire Warrant, free from preemptive rights or any other
contingent purchase rights of persons other than the Holder (taking into account the adjustments
and restrictions of Section 8 herein). The Company covenants that all Warrant Shares so
issuable and deliverable shall, upon issuance and the payment of the applicable Exercise Price in
accordance with the terms hereof, be duly and validly authorized, issued and fully paid and
nonassessable. The Company will take all such action as may be necessary to assure that such
shares of Common Stock may be issued as provided herein without violation of any applicable law or
regulation or of any requirements of any securities exchange or automated quotation system upon
which the Common Stock may be listed.

     8. Certain Adjustments. The Exercise Price and number of Warrant Shares issuable upon
exercise of this Warrant are subject to adjustment from time to time as set forth in this
Section 8.

          (a) Stock Dividends and Splits. If the Company, at any time while this Warrant is
outstanding, (i) pays a stock dividend on its Common Stock or otherwise makes a distribution on any

-3-

 

class of capital stock that is payable in shares of Common Stock, (ii) subdivides outstanding
shares of Common Stock into a larger number of shares, or (iii) combines outstanding shares of
Common Stock into a smaller number of shares, then in each such case the Exercise Price shall be
multiplied by a fraction of which the numerator shall be the number of shares of Common Stock
outstanding immediately before such event and of which the denominator shall be the number of
shares of Common Stock outstanding immediately after such event. Any adjustment made pursuant to
clause (i) of this paragraph shall become effective immediately after the record date for the
determination of stockholders entitled to receive such dividend or distribution, and any adjustment
pursuant to clause (ii) or (iii) of this paragraph shall become effective immediately after the
effective date of such subdivision or combination.

          (b) Pro Rata Distributions. If the Company, at any time while this Warrant is
outstanding, distributes to holders of Common Stock (i) evidences of its indebtedness, (ii) any
security (other than a distribution of Common Stock covered by the preceding paragraph), (iii)
rights or warrants to subscribe for or purchase any security, or (iv) any other asset, including
cash (in each case, “Distributed Property”), then in each such case the Exercise Price in
effect immediately prior to the record date fixed for determination of stockholders entitled to
receive such distribution shall be adjusted (effective on such record date) to equal the product of
such Exercise Price times a fraction of which the denominator shall be the average of the closing
prices for the Company’s Common Stock for the five trading days immediately prior to (but not
including) such record date and of which the numerator shall be such average less the then fair
market value of the Distributed Property distributed in respect of one outstanding share of Common
Stock, as determined (except in the case of cash) by the Company’s independent certified public
accountants that regularly examine the financial statements of the Company (an
“Appraiser”). In such event, the Holder, after receipt of the determination by the
Appraiser, shall have the right to select an additional appraiser (which shall be a recognized
accounting firm mutually acceptable to both the Holder and the Company), in which case such fair
market value shall be deemed to equal the average of the values determined by each of the Appraiser
and such appraiser.

          (c) Number of Warrant Shares. Simultaneously with any adjustment to the Exercise
Price pursuant to paragraph (a) of this Section 8, the number of Warrant Shares that may be
purchased upon exercise of this Warrant shall be increased or decreased proportionately, so that
after such adjustment the aggregate Exercise Price payable hereunder for the increased or decreased
number of Warrant Shares shall be the same as the aggregate Exercise Price in effect immediately
prior to such adjustment.

          (d) Calculations. All calculations under this Section 8 shall be made to the
nearest cent or the nearest 1/100th of a share, as applicable. The number of shares of Common
Stock outstanding at any given time shall not include shares owned or held by or for the account of
the Company, and the disposition of any such shares shall be considered an issue or sale of Common
Stock.

          (e) Notice of Adjustments. Upon the occurrence of each adjustment pursuant to this
Section 8, the Company at its expense will promptly compute such adjustment in accordance
with the terms of this Warrant and prepare a certificate setting forth such adjustment, including a
statement of the adjusted Exercise Price and adjusted number or type of Warrant Shares or other

-4-

 

securities, cash or property issuable upon exercise of this Warrant (as applicable),
describing the transactions giving rise to such adjustments and showing in detail the facts upon
which such adjustment is based. Upon written request, the Company will promptly deliver a copy of
each such certificate to the Holder and to the Company’s Transfer Agent.

     9. Representations, Warranties and Covenants of Holder.

          (a) The Holder understands and acknowledges that the Warrant and the Warrant Shares must be
held by the Holder indefinitely, and that the Holder must therefore bear the economic risk of such
investment indefinitely, unless a subsequent disposition thereof is registered under the Securities
Act or is exempted from such registration.

          (b) The Holder has such knowledge and experience in financial and business matters that it is
capable of evaluating the merits and risks of the purchase of this Warrant and the Warrant Shares
purchasable pursuant to the terms of this Warrant and of protecting its interests in connection
therewith.

          (c) The Holder agrees that for a period of five (5) years after the date of issuance of this
Warrant, it shall not purchase or sell, or make any offer to purchase or offer to sell, derivative
securities relating to the Company’s securities, whether or not issued by the Company, such as
exchange traded options to purchase or sell the Company’s securities (“puts” and “calls”), engage
in short sales or short sales “against the box” in the Company’s securities, or pledge or loan the
warrants or other Company securities in connection with any such transaction.

          (d) The Holder confirms that it is an authorized person for the purposes of the Financial
Services and Markets Act 2000.

          (e) The Holder is a not a U.S. Person and is not acquiring this Warrant for the account or
benefit of any U.S. Person. All capitalized terms used in this Section 9(e) but not
otherwise defined shall have the meaning given such terms in Regulation S.

               (i) The Holder has been advised and acknowledges that:

                    (A) the Warrant and the Warrant Shares have not been registered under the Securities Act by
reason of their issuance in a transaction exempt from the registration and prospectus delivery
requirements of the Securities Act pursuant to Regulation S thereunder and may not be offered or
sold within the United States or to, or for the account or benefit of, U.S. Persons except in
accordance with Regulation S or pursuant to an exemption from the registration requirements of the
Securities Act.

                    (B) it is a condition to the availability of the Regulation S “safe harbor” that the Warrant
and the Warrant Shares not be offered or sold in the United States or to a U.S. Person until the
expiration of a period of one year following the Closing Date; and

                    (C) notwithstanding the foregoing and subject to the exercisability of this Warrant, prior to
the expiration of one year after the date of this Warrant (the “Restricted Period”), this
Warrant and the Warrant Shares (to the extent this Warrant is exercisable) may be

-5-

 

offered and sold by the holder thereof only if such offer and sale is made in compliance with
the terms of this Warrant and either: (A) if the offer or sale is within the United States or to
or for the account of a U.S. Person, the securities are offered and sold pursuant to an effective
registration statement or pursuant to an exemption from the registration requirements of the
Securities Act; or (B) the offer and sale is outside the United States and to other than a U.S.
Person.

               (ii) The Holder agrees that with respect to this Warrant and the Warrant Shares until the
expiration of the Restricted Period:

                    (A) the Holder, its agents or its representatives have not and will not solicit offers to buy,
offer for sale or sell this Warrant or any of the Warrant Shares, or any beneficial interest
therein in the United States or to or for the account of a U.S. Person during the Restricted
Period;

                    (B) notwithstanding the foregoing, prior to the expiration of the Restricted Period, this
Warrant and the Warrant Shares (to the extent this Warrant is exercisable) may be offered and sold
by the Holder only if such offer and sale is made in compliance with the terms of this Warrant and
either: (A) if the offer or sale is within the United States or to or for the account of a U.S.
Person, the securities are offered and sold pursuant to an effective registration statement or
pursuant to an exemption from the registration requirements of the Securities Act; or (B) the offer
and sale is outside the United States and to other than a U.S. Person; and

                    (C) the Holder shall not engage in hedging transactions with regard to this Warrant or the
Warrant Shares unless in compliance with the Securities Act and Section 9(c) of this
Warrant.

The foregoing restrictions are binding upon subsequent transferees of this Warrant and/or the
Warrant Shares, except for transferees pursuant to an effective registration statement. The Holder
agrees that after the Restricted Period, this Warrant and the Warrant Shares (to the extent this
Warrant is exercisable) may be offered or sold within the United States or to or for the account of
a U.S. Person only pursuant to applicable securities laws.

               (iii) The Holder has not engaged, nor is it aware that any party has engaged, and the Holder
will not engage or cause any third party to engage, in any directed selling efforts (as such term
is defined in Regulation S) in the United States with respect to this Warrant or the Warrant
Shares.

               (iv) The Holder: (i) is domiciled and has its principal place of business outside the United
States; (ii) certifies it is not a U.S. person and is not acquiring this Warrant or the Warrant
Shares for the account or benefit of any U.S. person; and (iii) represents that at the time of the
issuance of this Warrant, the Holder or persons acting on the Holder’s behalf in connection
therewith will be located outside the United States.

               (v) At the time of offering to the Holder and communication of the Holder’s order to purchase
this Warrant or the Warrant Shares (to the extent this Warrant is

-6-

 

exercisable) and at the time of the Holder’s execution of this Warrant, the Holder or persons
acting on the Holder’s behalf in connection therewith were located outside the United States.

               (vi) the Holder acknowledges that the Company shall make a notation in the Warrant Register
and in its stock books regarding the restrictions on transfer set forth in this Section
9(e) and shall transfer such shares on the books of the Company only to the extent consistent
therewith.

In particular, the Holder acknowledges that the Company shall refuse to register any transfer of
this Warrant or the Warrant Shares not made in accordance with the provisions of Regulation S,
pursuant to registration under the Securities Act or pursuant to an available exemption from
registration.

     10. Restrictive Legend. The Holder understands and agrees that each certificate held
by the Holder representing the Warrant Shares, or any other securities issued in respect of the
Warrant Shares upon any stock split, stock dividend, recapitalization, merger, consolidation or
similar event, shall bear the following legend (in addition to any legend required by applicable
state securities laws):

THE SECURITIES REPRESENTED HEREBY HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
OF 1933, AS AMENDED (THE “SECURITIES ACT”), AND MAY NOT BE SOLD, TRANSFERRED,
ASSIGNED, PLEDGED OR HYPOTHECATED EXCEPT IN ACCORDANCE WITH THE PROVISIONS OF
REGULATION S PROMULGATED UNDER THE SECURITIES ACT, PURSUANT TO REGISTRATION UNDER
THE SECURITIES ACT OR PURSUANT TO AN AVAILABLE EXEMPTION FROM REGISTRATION. HEDGING
TRANSACTIONS INVOLVING THE SECURITIES REPRESENTED HEREBY MAY NOT BE CONDUCTED UNLESS
IN COMPLIANCE WITH THE SECURITIES ACT. THIS CERTIFICATE MUST BE SURRENDERED TO THE
COMPANY OR ITS TRANSFER AGENT AS A CONDITION PRECEDENT TO THE SALE, PLEDGE,
HYPOTHECATION OR ANY OTHER TRANSFER OF ANY INTEREST IN ANY OF THE SECURITIES
REPRESENTED BY THIS CERTIFICATE.

     11. Payment of Exercise Price. The Holder shall pay the Exercise Price in one of the
following manners:

          (a) Cash Exercise. The Holder may deliver immediately available funds; or

          (b) Cashless Exercise. The Holder may satisfy its obligation to pay the Exercise
Price through a “cashless exercise,” in which event the Company shall issue to the Holder the
number of Warrant Shares determined as follows:

	 	 	 
	

	 	X = Y [(A-B)/A]
	 
	 	 
	where:
	 	 
	 
	 	 
	

	 	X = the number of Warrant Shares to be issued to the Holder.
	 
	 	 

-7-

 

	 	 	 
	

	 	Y = the number of Warrant Shares with respect to which this Warrant is
	

	 	being exercised.
	 
	 	 
	

	 	A = the average of the closing prices for the five trading days
	

	 	immediately prior to (but not including) the Exercise Date.
	 
	 	 
	

	 	B = the Exercise Price.

     For purposes of Rule 144 promulgated under the Securities Act, it is intended, understood and
acknowledged that the Warrant Shares issued in a cashless exercise transaction shall be deemed to
have been acquired by the Holder, and the holding period for the Warrant Shares shall be deemed to
have commenced, on the date this Warrant was originally issued pursuant to the Placement Agent
Agreement.

     12. Fractional Shares. The Company shall not be required to issue or cause to be
issued fractional Warrant Shares on the exercise of this Warrant. If any fraction of a Warrant
Share would, except for the provisions of this Section, be issuable upon exercise of this Warrant,
the number of Warrant Shares to be issued will be rounded up to the nearest whole share.

     13. Notices. Any and all notices or other communications or deliveries hereunder
(including without limitation any Exercise Notice) shall be in writing and shall be deemed given
and effective on the earliest of (i) the date of transmission, if such notice or communication is
delivered via facsimile prior to 5:00 p.m. (Austin, Texas time) on any business day, (ii) the next
business day after the date of transmission, if such notice or communication is delivered via
facsimile on a day that is not a business day or later than 5:00 p.m. (Austin, Texas time) on any
business day, (iii) the business day following the date of mailing, if sent by nationally
recognized overnight courier service, or (iv) upon actual receipt by the party to whom such notice
is required to be given. The address for such notices or communications to the Company shall be as
set forth in the Placement Agent Agreement, and for the Holder shall be as follows:

     [___]

     [___]

     [___]

     14. Miscellaneous.

          (a) This Warrant shall be binding on and inure to the benefit of the parties hereto and their
respective successors and assigns. Subject to the preceding sentence, nothing in this Warrant
shall be construed to give to any Person other than the Company and the Holder any legal or
equitable right, remedy or cause of action under this Warrant. This Warrant may be amended only in
writing signed by the Company and the Holder or their respective successors and assigns.

          (b) The Company will not, by amendment of its governing documents or through any
reorganization, transfer of assets, consolidation, merger, dissolution, issue or sale of securities
or any other voluntary action, avoid or seek to avoid the observance or performance of any of the
terms

-8-

 

of this Warrant, but will at all times in good faith assist in the carrying out of all such
terms and in the taking of all such action as may be necessary or appropriate in order to protect
the rights of the Holder against impairment. Without limiting the generality of the foregoing, the
Company (a) will not increase the par value of any Warrant Shares above the amount payable therefor
on such exercise, (b) will take all such action as may be reasonably necessary or appropriate in
order that the Company may validly and legally issue fully paid and nonassessable Warrant Shares on
the exercise of this Warrant, and (c) will not close its stockholder books or records in any manner
which interferes with the timely exercise of this Warrant.

          (c) GOVERNING LAW; VENUE. THE CORPORATE LAWS OF THE STATE OF DELAWARE SHALL GOVERN
ALL ISSUES CONCERNING THE RELATIVE RIGHTS OF THE COMPANY, ITS STOCKHOLDERS AND THE HOLDER OF THIS
WARRANT. EACH PARTY HEREBY IRREVOCABLY SUBMITS TO THE EXCLUSIVE JURISDICTION AND VENUE OF THE
STATE AND FEDERAL COURTS SITTING IN AUSTIN, TEXAS, FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR
IN CONNECTION HEREWITH OR WITH ANY TRANSACTION CONTEMPLATED HEREBY OR DISCUSSED HEREIN, AND HEREBY
IRREVOCABLY WAIVES, AND AGREES NOT TO ASSERT IN ANY SUIT, ACTION OR PROCEEDING, ANY CLAIM THAT IT
IS NOT PERSONALLY SUBJECT TO THE JURISDICTION OF ANY SUCH COURT, THAT SUCH SUIT, ACTION OR
PROCEEDING IS IMPROPER. EACH PARTY HEREBY IRREVOCABLY WAIVES PERSONAL SERVICE OF PROCESS AND
CONSENTS TO PROCESS BEING SERVED IN ANY SUCH SUIT, ACTION OR PROCEEDING BY MAILING A COPY THEREOF
VIA REGISTERED OR CERTIFIED MAIL OR OVERNIGHT DELIVERY (WITH EVIDENCE OF DELIVERY) TO SUCH PARTY AT
THE ADDRESS IN EFFECT FOR NOTICES TO IT UNDER THIS AGREEMENT AND AGREES THAT SUCH SERVICE SHALL
CONSTITUTE GOOD AND SUFFICIENT SERVICE OF PROCESS AND NOTICE THEREOF. NOTHING CONTAINED HEREIN
SHALL BE DEEMED TO LIMIT IN ANY WAY ANY RIGHT TO SERVE PROCESS IN ANY MANNER PERMITTED BY LAW.

          (d) The headings herein are for convenience only, do not constitute a part of this Warrant and
shall not be deemed to limit or affect any of the provisions hereof.

          (e) In case any one or more of the provisions of this Warrant shall be invalid or
unenforceable in any respect, the validity and enforceability of the remaining terms and provisions
of this Warrant shall not in any way be affected or impaired thereby and the parties will attempt
in good faith to agree upon a valid and enforceable provision which shall be a commercially
reasonable substitute therefor, and upon so agreeing, shall incorporate such substitute provision
in this Warrant.

[Remainder of Page Intentionally Left Blank.]

-9-

 

     IN WITNESS WHEREOF, the Company has caused this Warrant to be duly executed by its authorized
officer as of the date first indicated above, and Holder has agreed to the terms hereof.

	 	 	 
	 

	 	INTROGEN THERAPEUTICS, INC.
	 
	 	 
	 

	 	By:  

	 

	 	Name:  

	 

	 	Title:  

	 
	 	 
	 

	 	ACCEPTED:
	 
	 	 
	 
	 	 

	 

	 	[                     ]

 

FORM OF EXERCISE NOTICE

     (To be executed by the Holder to exercise the right to purchase shares of Common Stock under
the foregoing Warrant)

	 	 	 
	To:

	 	Introgen Therapeutics, Inc.
	

	 	301 Congress Avenue, Suite 1850
	

	 	Austin, Texas 78701
	

	 	Attn: Secretary

The undersigned is the Holder of Warrant No. ___(the “Warrant”) issued by Introgen
Therapeutics, Inc., a Delaware corporation (the “Company”). Capitalized terms used herein
and not otherwise defined have the respective meanings set forth in the Warrant.

	1.	 	The Warrant is currently exercisable to purchase a total of ___Warrant Shares.
	 
	2.	 	The undersigned Holder hereby exercises its right to purchase ___Warrant Shares
pursuant to the Warrant.
	 
	3.	 	The Holder intends that payment of the Exercise Price shall be made as (check one):

                    o“          Cash Exercise” under Section 11(a)

                    o“          Cashless Exercise” under Section 11(b)

	4.	 	If the holder has elected a Cash Exercise, the holder shall pay the sum of $___to
the Company in accordance with the terms of the Warrant.
	 
	5.	 	Pursuant to this exercise, the Company shall deliver to the holder ___Warrant
Shares in accordance with the terms of the Warrant.
	 
	6.	 	Following this exercise, the Warrant shall be exercisable to purchase a total of ___
Warrant Shares.

	 	 	 
	Dated: 

	 	Name of Holder:
	 

	 	
	 

	 	(Print) 

	 

	 	
	 

	 	By:  

	 

	 	Name:  

	 

	 	Title:  

	 

	 	
	 

	 	(Signature must conform in all respects to name of holder as specified on the face of the Warrant)

-2-

 

FORM OF ASSIGNMENT

[To be completed and signed only upon transfer of Warrant]

     FOR VALUE RECEIVED, the undersigned hereby sells, assigns and transfers unto
___the right represented by the within Warrant to purchase ___
shares of Common Stock of Introgen Therapeutics, Inc. to which the within Warrant relates and
appoints ___attorney to transfer said right on the books of Introgen
Therapeutics, Inc. with full power of substitution in the premises.

	 	 	 
	Dated: 

	 	 
	

	 	

	 

	 	(Signature must conform in all respects to name
	 

	 	of holder as specified on the face of the
	 

	 	Warrant)
	 
	 	 
	 

	 	

	 

	 	Address of Transferee
	 

	 	
	 

	 	

	 

	 	;

	 
	 	 
	In the presence of:

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