Document:

Amendment No. 1 to Lease Agreement, dated November 1, 2005

 Exhibit 10.28 
 FIRST AMENDMENT OF LEASE 
 This FIRST AMENDMENT OF LEASE is made as of the 1st day of
November, 2005 between BELLEMEAD DEVELOPMENT CORPORATION, a Delaware corporation (“Landlord”), having an address c/o The Gale Management Company, L.L.C., Park Avenue at Morris County, 100 Campus Drive, Suite 200, Florham Park, New
Jersey 07932 and ORCHID CELLMARK INC., a Delaware corporation, having an office at 4390 Route One, Princeton, New Jersey 08540 (hereinafter called “Tenant”) and a Federal Taxpayer Identification Number of 223392819. 
 W I T N E S S E T H : 
 WHEREAS: 
 A. Landlord and Orchid
Biosciences, Inc., the name by which Tenant was formerly known, heretofore entered into a certain lease dated December 19, 2000 (said lease as it may have been or may hereafter be amended is hereinafter called the “Lease”) with
respect to 21,014 rentable square feet (“Demised Premises”) on the first (1st) floor in the
office building known as and located at 4390 Route One, Princeton, New Jersey for a term ending on June 30, 2006; 
 B. Landlord and
Tenant are desirous of extending the term of the Lease by four (4) years and eight (8) months so that its expiration date is February 28, 2011; 
 C. Landlord and Tenant are desirous of having Tenant surrender pursuant to Section 2 hereof a 9,940 rentable square foot portion (the “Surrender Space”) of the Demised Premises, as shown on
Schedule A, attached hereto and made a part hereof; and 
 D. The parties hereto desire to further modify the Lease in certain other
respects. 
 NOW, THEREFORE, in consideration of the promises and mutual covenants hereinafter contained, the parties hereto modify the Lease
as follows: 
 1. DEFINED TERMS. Except as specifically provided otherwise in this First Amendment of Lease, all defined terms
contained in this First Amendment of Lease shall, for the purposes hereof, have the same meaning ascribed to them in the Lease. 

 2. SURRENDER SPACE. (A) Tenant shall deliver the Surrender Space to Landlord by the Requested
Surrender Date (hereinafter defined) in the same physical condition and state of repair that would apply to the Surrender Space if the Requested Surrender Date were the Expiration Date. Subject to the next sentence, the Requested Surrender
Date shall be the date falling thirty (30) days after Landlord receives and gives Tenant either a temporary or permanent certificate of occupancy from the governmental authority having jurisdiction over the Building for the Demised
Premises, exclusive of the Surrender Space. If any work, labor, materials or services are performed or furnished in all or any part of the Demised Premises that are not included in the Construction Plan, attached hereto as Schedule B and made a part
hereof, or if Tenant requests materials or work that differs from the materials or work in the Demised Premises as of the date hereof, then, notwithstanding anything contained to the contrary in the immediately preceding sentence, the Requested
Surrender Date shall be January 31, 2006. The earliest date on or after the Requested Surrender Date by when Tenant has delivered to Landlord the Surrender Space in the physical condition and state of repair as required hereunder is hereinafter
called the “Actual Surrender Date”. 
 (B) If the Actual Surrender Date occurs after the Requested Surrender Date,
then, commencing on the Requested Surrender Date, Tenant shall be deemed a tenant at sufferance unlawfully holding over in the Surrender Space and Tenant shall be liable to Landlord under Article 21 of the Lease as if the Requested 

  

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Surrender Date were the Expiration Date. As of the Actual Surrender Date, Exhibit A to the Lease shall be deemed to have excluded therefrom the Surrender
Space shown on Schedule A to this First Amendment of Lease. Nothing contained in this Paragraph shall be deemed to constitute a release or discharge of Tenant with respect to any outstanding and unsatisfied obligation or liability, whether unbilled
or calculated, accrued or incurred under the Lease, such as, but not limited to, Minimum Rent, Adjusted Minimum Rent, additional rent and other charges payable by Tenant, up to and including the Actual Surrender Date. If the Actual Surrender Date
occurs on or before the Requested Surrender Date, then, Tenant shall not be required to pay Landlord an amount equal to the sum total of the four (4) monthly Adjusted Minimum Rent installments referenced in Section 4.(c) hereof.

 3. TERM. Notwithstanding anything to the contrary contained in the Lease, the date set forth in the Lease for the expiration
thereof is hereby modified so that the Expiration Date shall be February 28, 2011. The parties agree that the Initial Term referenced in Section 3.4 of the Lease commenced on June 28, 2001 and ends on June 30, 2006. 

4. MINIMUM RENT. (A) The Lease is hereby amended to provide that the Minimum Rent, on an annual basis, shall be: 
 (i) Subject to Section 4.(C) hereof, TWO HUNDRED THIRTY EIGHT THOUSAND NINETY ONE AND 00/100 DOLLARS ($238,091.00) for the period beginning on
November 1, 2005 and ending on February 28, 2008, payable in advance on the first day of each calendar month in equal monthly installments of NINETEEN THOUSAND EIGHT HUNDRED FORTY AND 92/100 DOLLARS ($19,840.92); and 
 (ii) TWO HUNDRED FORTY NINE THOUSAND ONE HUNDRED SIXTY FIVE AND 00/100 DOLLARS ($249,165.00) for the period beginning on March 1, 2008 and ending on
the new Expiration Date of February 28, 2011, payable in advance on the first day of each calendar month in equal monthly installments of TWENTY THOUSAND SEVEN HUNDRED SIXTY THREE AND 75/100 DOLLARS ($20,763.75). 
  

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 (B) On the date hereof, Tenant shall give Landlord a fully and accurately completed W-9 Federal tax form
that has been properly executed by a duly authorized corporate officer of Tenant. 
 (C) Provided, prior to November 1, 2005, Tenant has
not breached any material term of the Lease (after receipt of any required written notice and beyond the expiration of any applicable grace period), then, Landlord agrees that the monthly installment of Adjusted Minimum Rent due on November 1,
2005 for November, 2005 shall be waived. Provided, prior to December 1, 2005, Tenant has not breached any material term of the Lease (after receipt of any required written notice and beyond the expiration of any applicable grace period), then,
Landlord agrees that the monthly installment of Adjusted Minimum Rent due on December 1, 2005 for December, 2005 shall be waived. Provided, prior to January 1, 2006, Tenant has not breached any material term of the Lease (after receipt of
any required written notice and beyond the expiration of any applicable grace period), then, Landlord agrees that the monthly installment of Adjusted Minimum Rent due on January 1, 2006 for January, 2006 shall be waived. Provided, prior to
February 1, 2006, Tenant has not breached any material term of the Lease (after receipt of any required written notice and beyond the expiration of any applicable grace period), then, Landlord agrees that the monthly installment of Adjusted
Minimum Rent due on February 1, 2006 for February, 2006 shall be waived. 
 5. REDUCED SIZE OF DEMISED PREMISES.
(A) Section 1.1(g) of the Lease shall be amended as of the date hereof to provide that beginning on November 1, 2005, and at all times thereafter, the Demised Premises shall be deemed to contain 11,074 rentable square feet.
Section 1.1(h) of the Lease shall be amended as of the date hereof to provide that beginning on November 1, 2005, and at all times thereafter, Tenant’s Occupancy Percentage, for 

  

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purposes of computing Tenant’s Share of Taxes and Tenant’s Share of Operating Costs arising solely from and related only to Taxes and Operating
Costs accruing after, not before, November 1, 2005, shall be deemed to be 17.4%. 
 (B) Notwithstanding anything contained to the the
contrary in Section 5.(A) hereof, the terms of Section 2.(B) hereof and Article 21 of the Lease shall prevail, govern and control if the Actual Surrender Date occurs after the Requested Surrender Date. 
 6. ESCALATIONS. For purposes of computing the additional rent accruing on and after November 1, 2005 that is due Landlord under
Section 6.1(a) of the Lease, as of November 1, 2005, (A) Section 1.1(i) of the Lease shall be deleted and replaced with the following new Section 1.1(i): 
 Base Taxes: The amount determined by multiplying (a) the real estate tax rate in effect on the date of this First Amendment of Lease and
(b) the assessed valuation of the Real Estate for the calendar year ending December 31, 2006, as such assessed valuation is or may be ultimately determined by final administrative or judicial proceeding, or by abatement by an appropriate
taxing authority. 
 ; and (B) Section 1.1(j) of the Lease shall be deleted and replaced with the following new Section 1.1(j): “First
Operating Year and First Tax Year: Year ending December 31, 2006”. For purposes of computing the additional rent accruing on and after November 1, 2005 that is due Landlord under Section 6.2(a) of the Lease, as of
November 1, 2005, Section 1.1(j) of the Lease shall be deleted and replaced with the new Section 1.1(j) recited in Section 6.(B) hereof. 
 7. BROKERAGE. (A) Tenant hereby represents and warrants that it has retained in writing The Staubach Company to act on Tenant’s behalf in connection with this First Amendment of Lease. Tenant also
represents that it has had no dealings or communications with any real estate broker or agent in connection with this First Amendment of Lease, except The Staubach Company 

  

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and the Gale Real Estate Advisors Company, L.L.C. (the “Brokers”). Tenant agrees to defend indemnify and hold Landlord, its
affiliates and/or subsidiaries and the partners, directors, officers of Landlord and its affiliates and/or subsidiaries harmless from and against any and all costs, expenses or liability (including reasonable attorney’s fees, court costs and
disbursements) for any commission or other compensation claimed by any broker or agent, excluding the Brokers, in connection with this First Amendment of Lease. 
 (B) Landlord covenants, represents and warrants that Landlord has had no dealing or communications with any broker or agent in connection with the consummation of this First Amendment of Lease, except the Brokers.
Landlord shall remit to the Brokers a real estate brokerage commission in connection with this First Amendment of Lease if, as and when earned, due and payable pursuant to the terms of a separate written agreement between Landlord and each of the
Brokers. If: (i) Landlord defaults under its separate written agreement with either or both Brokers regarding this First Amendment of Lease and the aggrieved Broker(s) make(s) a claim for commission against Tenant or (ii) Landlord has in
fact dealt or communicated with a broker or agent, other than the Brokers, in connection with this First Amendment of Lease, and a claim for commission is made against Tenant by such other broker or agent with whom Landlord has dealt, then, in
either case, Landlord shall pay, defend, indemnify and hold harmless Tenant, its partners, directors, officers and their affiliates and/or subsidiaries from and against any and all costs, expenses, including reasonable attorney’s fees (prior to
settlement, at trial or on appeal), court costs and disbursements, or liability for any commission or other compensation sought out of any such claim. 
 8. CORPORATE AUTHORITY. Tenant represents that the undersigned officer of the Tenant corporation has been duly 

  

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authorized on behalf of the Tenant corporation to enter into this First Amendment of Lease in accordance with the terms, covenants and conditions set forth
herein, and, upon Landlord’s request, Tenant shall deliver an appropriate certification by the corporate secretary of the Tenant corporation to the foregoing effect. 
 9. LEASE RATIFICATION. Except as expressly amended by this First Amendment of Lease, the Lease, and all terms, covenants and conditions thereof, shall remain in full force and effect and is hereby in all
respects ratified and confirmed. 
 10. NO ORAL CHANGES. This First Amendment of Lease may not be changed orally, but only by a
writing signed by both Landlord and Tenant. 
 11. NO DEFAULT. Tenant confirms that (i) Landlord has complied with all of its
obligations contained in the Lease and (ii) no event has occurred and no condition exists which, with the passage of time or the giving of notice, or both, would constitute a default by Landlord under the Lease. 
 12. NON-BINDING DRAFT. The mailing or delivery of this document by Landlord or its agent to Tenant, its agent or attorney shall not be deemed an
offer by the Landlord on the terms set forth in such document or draft, and such document or draft may be withdrawn or modified by Landlord or its agent at any time and for any reason. The purpose of this section is to place Tenant on notice that
this document or draft shall not be effective, nor shall Tenant have any rights with respect hereto, unless and until Landlord shall execute and accept this document. No representations or promises shall be binding on the parties hereto except those
representations and promises contained in a fully executed copy of this document or in some future writing signed by Landlord and Tenant. 
 13. RENEWAL OPTION. Tenant shall have a single option to renew the Lease for only one (1) term of five (5) years in 

  

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accordance with and subject to Article 51 of the Lease, except that: (i) the Renewal Term shall commence on March 1, 2011 and expire on the last
day of February in 2016; (ii) solely for purposes of Article 51, and for no other purpose whatsoever, the “Initial Term” shall be the four (4) year and eight (8) month period beginning July 1, 2006 and ending
February 28, 2011; (iii) the Minimum Rent during the Renewal Term shall be the greater of: (1) the Market Rent (defined in Section 51.4(b) of the Lease) or (2) the Adjusted Minimum Rent as of February 28, 2011,
(iv) the First Tax Year and First Operating Year during the Renewal Term shall be either: (1) 2011 if the Minimum Rent during the Renewal Term is Market Rent or (2) 2006 if the Minimum Rent during the Renewal term is the Adjusted
Minimum Rent as of February 28, 2011; and (v) Tenant’s Renewal Notice (defined in Section 51.2(a) of the Lease) shall be null and void and without legal force or binding effect unless received by Landlord no later than
May 31, 2010 (time being of the essence) but no sooner than December 31, 2009 (time being of the essence). 
 14. EXPANSION
OPTION. As of the date hereof, Tenant shall have a right of first offer, in accordance with and subject to Article 52 of the Lease, except that: (i) the Option Space shall mean space on the first (1st) floor of the Building that is contiguous to the Demised Premises and (ii) the phrase “; provided, however that... with
Section 52.1 hereof.” on lines 21 through 28 of Section 52.2 of the Lease is hereby rendered null and void and without legal force or binding effect. 
 15. NOTICES. On and after the date hereof, all notices to Landlord from Tenant shall be invalid (at Landlord’s option) unless, and shall be valid (at Landlord’s option) only if, in writing, sent
postage prepaid via certified mail, return receipt requested and addressed to Landlord as follows: 
 Bellemead Development Corporation

 c/o The Gale Management Company, L.L.C. 
 Park Avenue at Morris County 
 100 Campus Drive, Suite 200 
 Florham Park, New Jersey 07932 
 Attention:
Marc Leonard Ripp, Esq. 
                   Counsel

  

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 16. PARKING. At all times after the Requested Surrender Date, Tenant’s License for Allotted
Parking, referenced in Sections 1.1(q) and 10.2 of the Lease, shall be for forty four (44) cars. 
 17. PHYSICAL CONDITION.
(A) Tenant acknowledges that, as of the date hereof, Tenant is in occupancy of the Demised Premises and hereby accepts the Demised Premises in their “as is” physical condition and state of repair as of November 1, 2005. In this
regard, Landlord shall have no obligation to do any work, perform any services or grant any construction allowances, except as otherwise provided in Section 17.(B) hereof. 
 (B) Subject to the terms of this Section 17. (B), if, within ten (10) business days (time being of the essence) after Tenant receives from
Landlord plans and specifications prepared by Landlord for certain renovation work in the Demised Premises (“Renovation Work”) to be performed by The Gale Construction Company, L.L.C. (“Gale”), Landlord receives
from Tenant in writing Tenant’s written approval of such plans and specifications, then, Landlord shall give Tenant, upon Gale’s completion of the Renovation Work (the “Payment Date”), the Construction Credit (hereinafter
defined) to be applied only against Gale’s invoice to Tenant for the Renovation Work. Tenant agrees that said invoice from Gale may include: (a) Gale’s standard mark-ups for profit, overhead and general conditions and/or (b) a
fee established by Landlord for any supervisory, administrative and/or coordination services that Landlord may (but shall not be obligated to) perform in connection with the Renovation Work. Landlord and Tenant shall reasonably cooperate with each
other in promptly reviewing all plans and specifications. The plans and specifications shall be prepared by 

  

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Landlord at Tenant’s expense, but subject to the Construction Credit. The Construction Credit shall equal $102,965.00. Landlord’s obligation
to grant the Construction Credit to Tenant on the Payment Date shall be strictly conditioned upon and subject to each of the following: 
  

	 	(i)	Tenant shall not have breached (after receipt of any required written notice and beyond the expiration of any applicable grace period) any material term of the Lease on or before
the Payment Date; and 

  

	 	(ii)	Gale must perform the Renovation Work. 

 (C) Subject to
the Construction Credit, the cost charged by Gale to perform any work shall be borne entirely by Tenant, shall be payable by Tenant to Landlord as additional rent upon Landlord’s demand. Subject to Section 17.(D) hereof, if the amount due
to Gale for work performed is less than the Construction Credit, then, Tenant shall be deemed to have automatically forfeited said entire difference. 
 (D) If, by the date falling two (2) years after the date hereof, all or any portion of the Construction Credit remains unexpended, then, subject to the balance of this Section 17.(D), Tenant shall receive a
credit equal to of the lesser of: (a) that part of the Construction Credit remaining unexpended as of the date falling two (2) years after the date hereof, or (b) $55,370.00, which amount represents the product of $5.00 and 11,074.
The credit, if any, due Tenant under the immediately preceding sentence shall be applicable only against Minimum Rent attributable to, and due within, the period beginning on the date falling two (2) years and one (1) day after the date
hereof and ending on the date falling three (3) years after the date hereof. Tenant agrees and understands that if it is entitled to a credit computed in accordance with Section 17.(D)(b) hereof, Tenant shall be deemed to have
automatically forfeited the difference 

  

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between (1) the unexpended portion of the Construction Credit and (2) $55,370.00. Tenant shall be entitled to a credit under this
Section 17.(D) only if, and shall be entitled to no credit whatsoever unless, (i) Landlord receives from Tenant, no earlier than the date falling two (2) years and one (1) day after the date hereof, but no later than the date
falling three (3) years after the date hereof (time being of the essence), a written notice specifically referencing this Section 17.(D) and (ii) no breach of a material term under the Lease has occurred (after receipt of any required
written notice and beyond the expiration of any applicable grace period) before the date falling two (2) years and (1) day after the date hereof. 
 18. AUTOMATIC RENT DEBITS. As of the date hereof, the following Article 54 shall be deemed added to and made a part of the Lease: 
 54. AUTOMATIC RENT DEBITS 
 54.1 Automatic Rent Debits. Tenant agrees that all Minimum Rent, Adjusted Minimum Rent, and additional rent (collectively “Rent”) due under the Lease shall be paid by automatic debits
pursuant to and in accordance with the terms of this Article. 
 54.2 Transfer Account. On the date hereof, Tenant
shall deliver to Landlord either a check marked “VOID” or a savings account withdrawal slip, to indicate (i) the account from which Tenant desires its payments of Rent to be electronically transferred (the “Account”)
and (ii) the ABA routing number of the financial institution at which the Account is located. Tenant may not change or terminate the Account without prior written consent of Landlord, which consent of Landlord shall not be unreasonably
withheld, delayed or conditioned. Within ten (10) days after Landlord’s written demand, Tenant, at its expense, shall establish a replacement Account with any financial institution that Landlord identifies in writing to Tenant. Tenant, at
its expense, shall, within ten (10) days after Landlord’s written demand, complete, execute, acknowledge and deliver all documents, and otherwise undertake at Tenant’s expense all other measures, as Landlord may request to carry out
the provisions of this Article. 
  

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 54.3 Charge Authorization. Tenant authorizes Landlord and its bank
(“Agent”) to debit the Account monthly in an amount equal to the total Rent required of Tenant under the Lease on the date such payment is due. Tenant acknowledges and agrees that, subject to this Section and Section 54.4
hereof, for the entire Lease term, including all renewals and extensions, Landlord or Agent will debit monthly payments of Rent from the Account. Tenant acknowledges and agrees that the debits to the Account made or attempted to be made by Landlord
or Agent in no way lessen or alter Tenant’s obligations under the Lease, including, without limitation, those provisions regarding the amount of Rent, the amount of all adjustments to Rent, when payments are due, the application of payments and
the assessment of late payment charges and interest on delinquent rental payments. Tenant shall at all times be solely responsible for all fees, charges and expenses in any way related to (i) opening, maintaining and/or closing the Account or
(ii) any transfers in or from the Account. Tenant shall at all times maintain sufficient funds in the Account to cover the amount of each monthly debit to be made by Landlord or Agent under this Article. The failure to so maintain such funds
shall constitute a material monetary default by Tenant under the Lease. Tenant agrees that a copy of this Article may be delivered by Landlord to any financial institution for the purpose of confirming to that financial institution that Landlord, or
its Agent, is authorized to debit the Account monthly in accordance with and subject to the terms of this Article. 
 54.4
Termination. Upon no less than ten (10) days prior written notice to Tenant, Landlord may, at any time and from time to time, discontinue the automatic monthly debiting of the Account and require Tenant to pay all Rent by check or
electronic funds transfer to the address and in the manner required by Landlord. If Landlord opts to discontinue the automatic debiting of the Account, Landlord may thereafter, upon no less than ten (10) day’s prior written demand to
Tenant, reinstitute the automatic debiting of the Account in the same manner and subject to the same terms and conditions as are provided in this Article. 
 19. USA PATRIOT ACT. Tenant represents, warrants and covenants, to the best of its information, knowledge and belief, that neither Tenant nor any of its officers, directors or members (i) is listed on the
Specially Designated Nationals and Blocked Persons List maintained by the Office of Foreign Asset Control, 

  

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Department of the Treasury (“OFAC”) pursuant to Executive Order No. 13224, 66 Fed. Reg. 49079 (Sept. 25,
2001)(“Order”) and all applicable provisions of Title III of the USA PATRIOT ACT (Public Law No. 107-56 (October 26, 2001)); (ii) is listed on the Denied Persons List and Entity List maintained by the United States
Department of Commerce; (iii) is listed on the List of Terrorists and List of Disbarred Parties maintained by the United States Department of State, (iv) is listed on any list or qualification of “Designated Nationals” as defined
in the Cuban Assets Control Regulations 31 C.F.R. Part 515; (v) is listed on any other publicly available list of terrorists, terrorist organizations or narcotics traffickers maintained by the United States Department of State, the United
States Department of Commerce or any other governmental authority or pursuant to the Order, the rules and regulations of OFAC (including, without limitation, the Trading with the Enemy Act, 50 U.S.C. App. 1-44; the International Emergency Economic
Powers Act, 50 U.S.C. §§ 1701-06; the unrepealed provision of the Iraqi Sanctions Act, Publ.L. No. 101-513; the United Nations Participation Act, 22 U.S.C. § 2349 aa-9; The Cuban Democracy Act, 22 U.S.C. §§ 60-01-10;
The Cuban Liberty and Democratic Solidarity Act, 18.U.S.C. §§ 2332d and 233; and The Foreign Narcotic Kingpin Designation Act, Publ. L. No. 106-201, all as may be amended from time to time); or any other applicable requirements
contained in any enabling legislation or other Executive Orders in respect of the Order (the Order and such other rules, regulations, legislation or orders are collectively called the “Orders”); (vi) is engaged in activities
prohibited in the Orders; or (vii) has been convicted, pleaded nolo contendere, indicted, arraigned or custodially detained on charges involving money laundering or predicate crimes to money laundering, drug trafficking terrorist-related
activities or other money laundering predicate crimes or in connection with the Bank Secrecy Act (31 U.S.C. §§ 5311 et. seq.). 
  

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 20. SECURITY DEPOSIT. (A) Notwithstanding anything contained to the contrary in Sections
8.1(b), 8.2 and 8.3 of the Lease, but subject to the terms of Section 20.(B) hereof, Tenant shall give Landlord by no later than ten (10) business days after the date hereof (time being of the essence) a new Letter of Credit by and drawn
on a bank or trust company reasonably acceptable to Landlord for its account in the amount of $122,650.98. This Letter of Credit due from Tenant on the date hereof shall be an “evergreen” letter of credit which, subject to
Section 20.(B) hereof, shall remain effective during the entire term of this Lease, as it may be renewed or extended from time to time, so that the Letter of Credit may be drawn down through and including April 30, 2011, the date falling
two (2) months after the new Expiration Date of February 28, 2011. Provided Tenant strictly and timely complies with this Section 20.(A) and has not breached any material term of the Lease (after receipt of any required written notice
and beyond the expiration of any applicable grace period), Landlord shall return to Tenant after the date hereof: (i)the existing $122,650.98 letter of credit that was due from Tenant to Landlord on December 19, 2000 pursuant to
Section 8.1(a) of the Lease and (ii) the $10,000.00 cash portion of the Security referenced in Section 8.1(a)(i) of the Lease. 
 (B) Provided: (i) Tenant has not breached any material term of the Lease (after receipt of any required written notice and beyond the expiration of any applicable grace period) on or before December 14, 2006, (ii) Landlord
receives from Tenant a written demand notice referring to this Section 20.(B) no earlier than December 15, 2006, but no later than December 31, 2006, (iii) Landlord receives from Tenant, simultaneously with the written demand
notice referenced in subsection (ii) hereof, a 

  

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revised Letter of Credit in the sum of $41,527.50 containing the “evergreen” feature as described in Section 20.(A) hereof and
(iv) Landlord has not presented the $122,650.98 Letter of Credit due on the date hereof referenced in Section 20.(A) hereof, drawn thereon and applied or retained all or any part of the proceeds thereof, then, Landlord shall return to
Tenant the $122,650.98 Letter of Credit that was due on the date hereof. If Landlord so returns to Tenant the $122,650.98 Letter of Credit and Landlord at any time presents the $41,527.50 Letter of Credit, draws thereon (only after Tenant breaches a
material term of the Lease and fails to cure such breach after receipt of any required written notice and beyond the expiration of any applicable grace period) and applies or retains all or any part of the proceeds thereof, then, Tenant shall
forthwith deliver to Landlord a Letter of Credit in the sum of $41,527.50 that Landlord may hold for the entire term (as same may be renewed or extended) and present for payment, draw thereon and apply or retain the proceeds thereof. Notwithstanding
anything contained to the contrary in the immediately preceding sentence, none of Landlord’s rights or remedies at law, in equity or under the Lease, including, but not limited to Section 34.3 of the Lease, shall be diminished, abrogated,
waived, or restricted. 
 INTENTIONALLY LEFT BLANK 
  

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 IN WITNESS WHEREOF, the parties hereto have caused this First Amendment of Lease to be executed on the
day and year first written above. 
  

									
	 Signed and delivered
	 		 	
			
	 ATTESTED BY:
	 		 	 LANDLORD:

			
		 		 	 BELLEMEAD DEVELOPMENT CORPORATION

				
	 /s/ Joanne F. Meisler
	 		 	 By:
	 	 /s/ Adrian P. Slootmaker

	 Joanne F. Meisler, Esq.
 Corporate Secretary
	 		 		 	 Adrian Slootmaker
 Senior Vice President

			
	 APPLY CORPORATE SEAL HERE
	 		 	
			
	 WITNESSED BY:
	 		 	 AGENT FOR LANDLORD:

			
		 		 	 THE GALE MANAGEMENT COMPANY, L.L.C.

				
	 /s/ Marc Leonard Ripp
	 		 	 By:
	 	 /s/ Mark Yeager

	 Marc Leonard Ripp, Esq.
	 		 		 	 Mark Yeager

		 		 		 	 President

			
	 WITNESSED BY:
	 		 	 TENANT:

			
		 		 	 ORCHID CELLMARK INC.

				
	 /s/ Vera Telesh
	 		 	 By:
	 	 /s/ Raymond J. Land

	 Name: Vera Telesh
	 		 		 	 Name: Raymond J. Land

	             (please print)
	 		 		 	                 (please print)

		 		 		 	 Title CFO

		 		 		 	                 (please print)

  

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 SCHEDULE A 
 Floor Plan of 9,960 Rentable Square Foot 
 Surrender Space 

 SCHEDULE B 
 Construction PlanEmployment Agreement dated December 21, 2005

 Exhibit 10.29 
 December 21, 2005 
 Mr. Gordon Brown 
 87 Addis Drive 
 Churchville, PA 18966 
  

	Dear	Gordon: 

 We are pleased to make the following employment offer to you as
Senior Vice President—Global Lab Operations reporting directly to Paul Kelly, MD, President and Chief Executive Officer. We are looking forward to working with you and feel confident that you can add significant value to Orchid Cellmark (the
“Company”). The terms of your employment are detailed below. This letter agreement is referred to herein as the “Agreement.” 
  

			
	Base Salary:	  	$17,916.66 pre-tax per month (paid monthly, less applicable taxes and deductions). This is the equivalent of $215,000.00 annually.
		
	 Annual Bonus
 Target:
	  	Up to 30% of your base salary. Your annual bonus is based upon the number of full months employed in the performance year. The decision to award a bonus and the amount of the bonus, if any,
will be decided by the Company’s Board of Directors in its sole discretion based on your contribution and the Company’s performance.
		
	Equity:	  	It will be recommended that you be granted stock options to purchase 100,000 shares of Orchid Cellmark Inc. Common Stock pursuant to the Orchid 2005 Stock Plan, which describes this aspect of
your compensation. All stock option grants are contingent upon approval by the Compensation Committee of Orchid’s Board of Directors and are priced according to the grant date. The exercise price will be the closing price of the stock on the
grant date. These stock options will vest either based upon performance factors to be determined between you and Dr. Kelly; provided, that the performance factors will provide the opportunity for the stock options to be fully vested within three (3)
years of your Hire Date, or they will vest based upon time pro rata on a monthly basis over four (4) years. Orchid’s Stock Plan Administrator will provide you with a copy of the Plan and your Stock Option Agreement shortly after the
commencement of your employment.

			
	Mr. Gordon Brown	  	
		
		  	Additional option grants may be considered annually based upon your performance against objectives, your general contribution towards the Company’s success, and the Company’s
business situation, all as determined solely at the discretion of the Board of Directors.
		
	Benefits Plan:	  	As a full-time employee, you are eligible to participate in the Company sponsored medical, dental, vision, life and other insurance plans at some cost to you. The Human Resource Department
will provide you with detailed information on our current benefits at your new employee orientation. Your coverage will begin on your start date. Should you have any questions in the interim, please feel free to call Lauren Vazquez at (609)
750-2390.
		
	Executive Deferred Compensation:	  	The Company will contribute 5% of your annual base salary each year to an executive deferred compensation plan.
		
	Severance:	  	 If you receive written notice of termination from the Company that your employment is being terminated without “Cause”, or you give
written notice of resignation to the Company due to a “Constructive Dismissal”, or you receive written notice of termination from the Company that your employment is being terminated as a result of a “Change of Control” within
one (1) year following the Change of Control, then you shall be entitled to the following:
  
 Twelve (12) months of continued base salary (payable one-third within thirty (30) days after termination and the balance payable in twelve equal installments at the same time as your salary would otherwise be payable), plus at the end of
such twelve (12) month period the Company will pay to you an amount equal to a prorated portion of your bonus determined from January 1 of the year your employment terminated through the date of termination. In addition, during such twelve (12)
month period, if you elect continued coverage under COBRA, the Company will reimburse you for the same portion of your health insurance premiums for you and your family, to the same extent the Company paid those premiums during your employment. All
payments shall be less applicable taxes and deductions.
  
 For purposes of this Agreement
“Cause” shall mean that you have either (1) intentionally committed an act or omission that materially harms the Company; (2) been grossly negligent in performance of your duty to the Company, which is incapable of cure or not cured within
ten (10) business days of the date of receipt by you of notice of its existence; (3) committed an act of moral turpitude; (4) committed an act of fraud or material dishonesty in discharging your

  

 2 

			
	Mr. Gordon Brown	 	
		 	  
 duties to the Company; (5) materially breached this Agreement or any other
agreement you have with the Company; (6) breached any code of conduct or ethics or similar policy in effect at the Company, as all of the foregoing may be amended from time to time; or (7) engaged in any other act or commission that may be deemed
grounds for a “cause” termination under Delaware state law.
  
 For purposes of
this Agreement “Constructive Dismissal” shall mean the occurrence, without your express written consent, of any of the following: (i) a substantial diminution in the nature or status of your position, authority or primary duties or
responsibilities; or (ii) a material breach by the Company of this Agreement; provided, that there shall be no Constructive Dismissal unless you provide the Board of Directors and the Chief Executive Officer with written notice reasonably detailing
the purported basis for the Constructive Dismissal and the Company fails to remedy within sixty (60) business days after its receipt of such notice.
  
 For purposes of this agreement “Change of Control” means the occurrence of any of the following events:
  
 (i)     Ownership. Any
“Person” (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended) becomes the “Beneficial Owner” (as defined in Rule 13d-3 under said Act), directly or indirectly, of securities of the
Company representing 50% or more of the total voting power represented by the Company’s then outstanding voting securities (excluding for this purpose the Company or its Affiliates or any employee benefit plan of the Company) pursuant to a
transaction or a series of related transactions which the Board of Directors does not approve; or
  
 (ii)    Merger/Sale of Assets. A merger or consolidation of the Company whether or not approved by the Board
of Directors, other than a merger or consolidation which would result in the voting securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into voting securities
of the surviving entity or the parent of such entity) at least 50% of the total voting power represented by the voting securities of the Company or such surviving entity or parent of such corporation outstanding immediately after such merger or
consolidation, or the consummation of an agreement for the sale or disposition by the Company of all or substantially all of the Company’s assets. “Substantially all of the Company’s assets” shall be deemed to include the assets
of all business unites and /or divisions of the Company and all of its affiliates.

  

 3 

 Mr. Gordon Brown 
  

			
		
	Stock Purchase	  	You will be expected to purchase in the open-market either prior to or within six (6) months after your Hire Date, ten thousand dollars ($10,000) worth of the Common Stock of the Company, and
provide evidence thereof to the Vice President—Legal Affairs.
		
	Vacation:	  	You will be granted 5 weeks vacation annually which will accrue on a monthly basis.
		
	Sick Days:	  	Employees are allowed 5 sick days per year.
		
	Hire Date:	  	January 1, 2006.

 Dr. Kelly and you have discussed the possibility that the Company may seek to appoint a Chief Operating
Officer in the next twelve months. Subject to your performance and the performance of the Company, the Company expects that you would be considered for this position. However, you acknowledge and agree that the decision to appoint a Chief Operating
Officer or to appoint you as the Chief Operating Officer is subject to approval by the Company’s Board of Directors in its sole discretion, and that the Company shall have no liability or obligation to you if no Chief Operating Officer is
appointed or if you are not appointed as the Chief Operating Officer at any time. 
 Your employment with Orchid Cellmark is
contingent upon the following standard items: 
  

	 	(i)	your successful completion of a credit history check through our background screening process; 

  

	 	(ii)	you sign and be subject to a standard form of Employee Agreement (a copy of which is provided with this letter) and complete all appropriate forms provided to you during the
transition process; and 

  

	 	(iii)	the terms of your employment shall remain confidential. 

 Failure to meet any of these contingencies outlined above will make you ineligible for employment. 
 Anything in this
Agreement to the contrary notwithstanding, you acknowledge and agree that your employment with the Company is on an at will basis and is for no specified term and may be terminated by the Company at any time, with or without Cause. 
 This Agreement represents the Company’s and your entire understanding with respect to the subject matter hereof and supersedes all previous understandings, written
or oral, between the Company and you concerning the subject matter hereof. This Agreement may be amended or modified only in a writing signed by both a duly authorized officer of the Company and you. No oral waiver, amendment or modification shall
be effective under any circumstances whatsoever. This Agreement shall be governed by the laws of the State of Delaware. 
  

 4 

 Mr. Gordon Brown 
 If you
accept the above-described offer, please sign and return the original copy; the second copy is for your records. I look forward to your joining Orchid Cellmark. 
  

	
	 Sincerely,

	
	 /s/ Paul Kelly

	 Paul Kelly
 President and CEO

 Enclosures: 
 Offer Letter Package 
 ACKNOWLEDGMENT:

 I have read, understand and accept the foregoing terms and conditions of employment. I further understand that while my salary, benefits, job title
and job duties may change from time to time without written modification of this agreement, the at-will term of my employment (i.e., my right and the Company’s right to terminate our employment relationship at any time, with or without cause)
is a term of employment that cannot be altered or modified except in writing and signed by me and Orchid Cellmark’s CEO or Vice President—Legal Affairs. 
  

									
					
	 Name:
	 	 /s/ Gordon Brown
	 		 	 Date:
	 	 12/21/2005

  

 5

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