Document:

Restricted Stock Award Agreement, dated January 15, 2008, by and between Jason C

 Exhibit 10.27 
 Jason Cole 
 Name of Employee 
 COMBINATORX, INCORPORATED 
 2004 Incentive Plan 
 Restricted Stock Award Agreement 
 CombinatoRx,
Incorporated 
 245 First Street 
 Sixteenth Floor 
 Cambridge, MA 02142 
 Attn: Alexis Borisy 
 Ladies and Gentlemen: 
 The undersigned
(i) acknowledges that on January 15, 2008, he received an award (the “Award”) of restricted stock from CombinatoRx, Incorporated (the “Company”) under the 2004 Incentive Plan (the “Plan”), (ii) hereby
agrees to amend the terms of such award, subject to the terms set forth below and in the Plan; (iii) further acknowledges receipt of a copy of the Plan as in effect on the date hereof; and (iv) agrees with the Company as follows:

  

	 	1.	Effective Date. This Agreement shall take effect as of January 15, 2008, which is the date of grant of the Award. 

  

	 	2.	Shares Subject to Award. The Award consists of 25,000 shares (the “Shares”) of common stock of the Company (“Stock”). The undersigned’s rights
to the Shares are subject to the restrictions described in this Agreement and the Plan (which is incorporated herein by reference with the same effect as if set forth herein in full) in addition to such other restrictions, if any, as may be imposed
by law. 

  

	 	3.	Meaning of Certain Terms. Except as otherwise expressly provided, all terms used herein shall have the same meaning as in the Plan. The term “vest” as used
herein with respect to any Share means the lapsing of the restrictions described herein with respect to such Share. 

  

	 	4.	Nontransferability of Shares. The Shares acquired by the undersigned pursuant to this Agreement shall not be sold, transferred, pledged, assigned or otherwise
encumbered or disposed of except as provided below and in the Plan. 

  

	 	5.	Accelerated Vesting of Unvested Shares After a Change of Control. If a Change of Control (as defined below) occurs, and within two (2) years following the
consummation date of such Change of Control the Company terminates employment of the undersigned other than for Cause (as defined below), then all unvested Shares will immediately become vested. 

 For purposes of this Agreement, the term “Change of Control” shall mean: (a) a sale, merger or consolidation after which securities
possessing more than fifty (50%) percent of the total combined voting power of the Company’s outstanding securities have been transferred to or 

 
acquired by a person or persons different from the persons who held such percentage of the total combined voting power immediately prior to such transaction;
or (b) the sale, transfer or other disposition of all or substantially all of the Company’s assets to one or more persons (other than a wholly owned subsidiary of the Company or a parent company whose stock ownership after the transaction
is the same as the Company’s ownership before the transaction); or (c) an acquisition, merger or similar transaction or a divestiture of a substantial portion of the Company’s business after which the role of the undersigned is not
substantially the same as such role prior to the transaction. 
 For the purposes of this Agreement, the term “Cause” shall mean
(a) the conviction of the undersigned of any felony; (b) the willful failure to perform or gross negligence in the performance of the duties and responsibilities of the undersigned in accordance with the terms or requirements of her
employment; (c) material breach by the undersigned of any terms or requirements of her employment, which breach continues or remains uncured after thirty (30) days’ notice to the undersigned setting forth in reasonable detail the
nature of such breach; or (d) engaging in material fraudulent conduct toward the Company. 
  

	 	6.	Forfeiture Risk. If the undersigned ceases to be employed by the Company and its subsidiaries because of death or disability or for any reason other than as specified
in Section 5 above, any then outstanding and unvested Shares acquired by the undersigned hereunder shall be automatically and immediately forfeited. With respect to any Shares that are forfeited under this Section 6, the undersigned hereby
(i) appoints the Company as the attorney-in-fact of the undersigned to take such actions as may be necessary or appropriate to effectuate a transfer of the record ownership of any such shares that are unvested and forfeited hereunder,
(ii) agrees to deliver to the Company, as a precondition to the issuance of any certificate or certificates with respect to unvested Shares hereunder, one or more stock powers, endorsed in blank, with respect to such Shares, and
(iii) agrees to sign such other powers and take such other actions as the Company may reasonably request to accomplish the transfer or forfeiture of any unvested Shares that are forfeited hereunder. 

  

	 	7.	Retention of Certificates. Any certificates representing unvested Shares shall be held by the Company. If unvested Shares are held in book entry form, the undersigned
agrees that the Company may give stop transfer instructions to the depository to ensure compliance with the provisions hereof. 

  

	 	8.	Vesting of Shares. The shares acquired hereunder shall vest in accordance with the provisions of this Section 8 and applicable provisions of the Plan, as follows:
25% percent of the Shares on January 15, 2009 and an additional 25% on each anniversary thereafter until January 15, 2012. 

 Notwithstanding the foregoing, no shares shall vest on any vesting date specified above unless the undersigned is then, and since the date of grant has continuously been, employed by the Company or its subsidiaries. 
  

	 	9.	Legends. Any certificates representing unvested Shares shall be held by the Company, and any such certificate shall contain legends substantially in the following
form: 

 THE TRANSFERABILITY OF THIS CERTIFICATE AND THE SHARES OF STOCK REPRESENTED HEREBY ARE SUBJECT TO THE TERMS AND
CONDITIONS (INCLUDING FORFEITURE) OF THE 2004 INCENTIVE PLAN AND A RESTRICTED STOCK AWARD AGREEMENT ENTERED INTO BETWEEN THE 

  

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REGISTERED OWNER AND COMBINATORX, INCORPORATED. COPIES OF SUCH PLAN AND AGREEMENT ARE ON FILE IN THE OFFICES OF COMBINATORX, INCORPORATED. 
 THESE SECURITIES HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED, OR HYPOTHECATED
IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THE SECURITIES UNDER SAID ACT OR AN OPINION OF COUNSEL SATISFACTORY TO THE COMPANY, THAT SUCH REGISTRATION IS NOT REQUIRED. 
 As soon as practicable following the vesting of any such Shares the Company shall cause a certificate or certificates covering such vested Shares to be
issued and delivered to the undersigned without the first legend set forth above referencing the Restricted Stock Award Agreement. If any Shares are held in book-entry form, the Company may take such steps as it deems necessary or appropriate to
record and manifest the restrictions applicable to such Shares. 
  

	 	10.	Dividends, etc.. The undersigned shall be entitled to (i) receive any and all dividends or other distributions paid with respect to those Shares of which he is
the record owner on the record date for such dividend or other distribution, and (ii) vote any Shares of which he is the record owner on the record date for such vote; provided, however, that any property (other than cash) distributed
with respect to a share of Stock (the “associated share”) acquired hereunder, including without limitation a distribution of Stock by reason of a stock dividend, stock split or otherwise, or a distribution of other securities with respect
to an associated share, shall be subject to the restrictions of this Agreement in the same manner and for so long as the associated share remains subject to such restrictions, and shall be promptly forfeited if and when the associated share is so
forfeited; and further provided, that the Administrator may require that any cash distribution with respect to the Shares other than a normal cash dividend be placed in escrow or otherwise made subject to such restrictions as the
Administrator deems appropriate to carry out the intent of the Plan. References in this Agreement to the Shares shall refer, mutatis mutandis, to any such restricted amounts. 

  

	 	11.	Sale of Vested Shares. The undersigned understands that he will be free to sell any Share once it has vested, subject to (i) satisfaction of any applicable tax
withholding requirements with respect to the vesting or transfer of such Share; (ii) the completion of any administrative steps (for example, but without limitation, the transfer of certificates) that the Company may reasonably impose; and
(iii) applicable requirements of federal and state securities laws. 

  

	 	12.	Certain Tax Matters. The undersigned expressly acknowledges the following: 

  

	 	a.	The undersigned has been advised to confer promptly with a professional tax advisor to consider whether the undersigned should make a so-called “83(b) election” with
respect to the Shares. Any such election, to be effective, must be made in accordance with applicable regulations and within thirty (30) days following the date of this Award. The Company has made no recommendation to the undersigned with
respect to the advisability of making such an election. 

  

	 	b.	 The award or vesting of the Shares acquired hereunder, and the payment of dividends with respect to such Shares, may give rise to “wages” subject to
withholding. The undersigned expressly acknowledges and agrees that his rights hereunder are subject 

  

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to his promptly paying to the Company in cash (or by such other means as may be acceptable to the Company in its discretion, including, if the Administrator
so determines, by the delivery of previously acquired Stock or shares of Stock acquired hereunder or by the withholding of amounts from any payment hereunder) all taxes required to be withheld in connection with such award, vesting or payment.

  

	
	Very truly yours,
	
	 /s/ Jason F. Cole

	(Signature of Employee)

 Dated: January 15, 2008 
  

			
	The foregoing Restricted Stock Award Agreement is hereby accepted:
	
	COMBINATORX, INCORPORATED
		
	By	 	 /s/ Alexis Borisy

  

 -4-Letter Agreement, dated February 7, 2008, between Curtis Keith and the Registran

 Exhibit 10.28 
 February 7, 2008 
 Curtis Keith 
 115 Pembroke
St., Apt. #3 
 Boston, MA 02118 
 Dear Curtis: 
 This letter agreement is regarding your outstanding options to purchase shares of common stock of CombinatoRx, Incorporated (the “Company”) and changes to the
Stock Option Agreements (“Agreements”) previously entered into from time to time between you and the Company. 
  

	 	1.	As of your last day of employment with the Company, you have vested and exercisable options to purchase 272,135 (two hundred seventy-two thousand one hundred thirty-five) shares of
the Company’s common stock (the “Vested Options”). No further vesting shall take place for these previously granted options and the maximum number of shares which may be purchased by you pursuant to the Agreements is 272,135 (two
hundred seventy-two thousand one hundred thirty-five) shares of common stock. 

  

	 	2.	The Agreements are all hereby modified such that the requirements of continuous employment set forth in the Agreements (solely for purposes of exercising the Vested Options) are
hereby amended to substitute your continuous involvement as a member of the CombinatoRx Scientific Advisory Board or engagement as a consultant to the Company as the service requirement. As a result, whenever your continuous involvement with the
Scientific Advisory Board or engagement as a consultant to the Company ends, you will have 90 days to exercise the Vested Options. If the Vested Options are unexercised within 90 days thereafter, the vested and unexercised options will be
irrevocably cancelled. 

  

	 	3.	Notwithstanding the provisions of any section of the Agreements, the Agreements shall now be deemed not to be an option qualifying as an incentive stock options within the meaning
of Section 422 of the Internal Revenue Code of 1986, as amended or replaced from time to time. 

  

	 	4.	As modified hereby, the Agreements shall continue in force in accordance with their terms. 

 If you agree to the terms of this letter, please countersign one copy of this letter and return it in the enclosed stamped envelope. 
 Best regards, 
  

			
	 /s/ Alexis Borisy

	Alexis Borisy
	President and Chief Executive Officer

  

			
	Agreed by:	 	 /s/ Curtis Keith

		 	Curtis Keith

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