Document:

EX-4.1

 Exhibit 4.1 
  

 

 The Corporation shall furnish without charge to each stockholder who so requests a statement of
the powers, designations, preferences and relative, participating, optional or other special rights of each class of stock of the Corporation or series thereof and the qualifications, limitations or restrictions of such preferences and/or rights.
Such requests shall be made to the Corporation’s Secretary at the principal office of the Corporation. 
 KEEP THIS CERTIFICATE IN A
SAFE PLACE. IF IT IS LOST, STOLEN, OR DESTROYED THE CORPORATION WILL REQUIRE A BOND INDEMNITY AS A CONDITION TO THE ISSUANCE OF A REPLACEMENT CERTIFICATE. 

The following abbreviations, when used in the inscription on the face of this certificate, shall be construed as though they were written out
in full according to applicable laws or regulations: 
  

															
	TEN COM	 	–	 	as tenants in common	 	UNIF GIFT MIN ACT	 	–                               	 	Custodian                                  
                                         
          
	TEN ENT	 	–	 	as tenants by the entireties	 		 	                (Cust)	 	                                    
        (Minor)
	JT TEN	 	–	 	as joint tenants with right of survivorship and not as tenants in common	 		 	under Uniform Gifts to Minors
		 		 	 		 	Act                                   
                                         
                                         
        
		 		 	 		 		 		 	        (State)	  	
	COM PROP	 	–	 	as community property	 	UNIF TRF MIN ACT	 	–                               	 	Custodian (until age                        )
		 		 		 		 	            (Cust)	 	
		 		 		 		 	                                	 	under Uniform Transfers
		 		 		 		 	            (Minor)	 		  	
		 		 		 		 	to Minors Act
                                         
                                         
                            
		 		 		 		 		 	                                    
            (State)

 Additional abbreviations may also be used though not in the above list. 

 

			
	FOR VALUE RECEIVED,                                 
                                         
  	  	hereby sell(s), assign(s) and transfer(s) unto

  

					
	PLEASE INSERT SOCIAL SECURITY OR OTHER	 		 	
	IDENTIFYING NUMBER OF ASSIGNEE	 		 	
	 	 		 	
	 	 		 	

  

	
	  
 (PLEASE PRINT OR
TYPEWRITE NAME AND ADDRESS, INCLUDING ZIP CODE, OF ASSIGNEE)

	
	  

	
	  

	
	                                      
                                         
                                         
                                         
                                         
   shares
	of the capital stock represented by within Certificate, and do hereby irrevocably constitute and appoint
	                                      
                                         
                                         
                                         
                           attorney-in-fact
	to transfer the said stock on the books of the within named Corporation with full power of the substitution in the premises.

Dated                         
                                         
                        
  

							
		 	x	 	                                    
                                         
                                         
                                         
       
			
		 	x	 	                                   
                                         
                                         
                                         
        
	Signature(s) Guaranteed:        	 		 	NOTICE:	 	THE SIGNATURE TO THIS ASSIGNMENT MUST CORRESPOND WITH THE NAME AS WRITTEN UPON THE FACE OF THE CERTIFICATE IN EVERY PARTICULAR, WITHOUT ALTERATION OR ENLARGEMENT OR ANY CHANGE WHATSOEVER.
		 		 		 
		 		 		 

  

			
	By	 	  

	THE SIGNATURE(S) SHOULD BE GUARANTEED BY AN ELIGIBLE GUARANTOR INSTITUTION, (BANKS, STOCKBROKERS, SAVINGS AND LOAN ASSOCIATIONS AND CREDIT UNIONS WITH MEMBERSHIP IN AN APPROVED SIGNATURE
GUARANTEE MEDALLION PROGRAM), PURSUANT TO S.E.C. RULE 17Ad-15. GUARANTEES BY A NOTARY PUBLIC ARE NOT ACCEPTABLE. SIGNATURE GUARANTEES MUST NOT BE DATED.EX-4.2

 Exhibit 4.2 

KURA ONCOLOGY, INC. 

REGISTRATION RIGHTS AGREEMENT 

This REGISTRATION RIGHTS AGREEMENT (this “Agreement”) is made as of March 6, 2015, by and among (i) Kura Oncology,
Inc., a Delaware corporation (the “Company”), (ii) each person listed on Schedule A attached hereto (together with any transferees who become parties hereto as “Investors” pursuant to
Section 8(f), each individually, an “Investor” and collectively, the “Investors”), (iii) each officer or director of the Company or holder of Outstanding Capital Stock (as defined below) who becomes
a party hereto as an “Existing Stockholder” by signing Exhibit A attached hereto, as listed on Schedule B (together with any transferees who become parties hereto as “Existing Stockholders” pursuant to
Section 8(f), each individually, an “Existing Stockholder” and collectively, the “Existing Stockholders”), and (iv) Zeta Acquisition Corp. III, a Delaware corporation (“Zeta”), but
only for purposes of assuming all of the Company’s rights, duties and obligations hereunder pursuant to Section 8. The Investors and Existing Stockholders are referred to herein, collectively, as the “Stockholders”.
In the event that a Person is both an Investor and an Existing Stockholder, then, to the extent that the provisions of this Agreement apply differently to Investors than Existing Stockholders, such provisions shall apply to such Person as an
Investor with respect to the shares of Common Stock acquired pursuant to the Purchase Agreement (as defined herein) and as an Existing Stockholder with respect to the shares of Common Stock that were Outstanding Capital Stock. Capitalized terms used
herein and not otherwise defined shall have the meanings ascribed to them in Section 8(q) herein. 
 BACKGROUND 

The Company has agreed to issue and sell to the Investors, and the Investors have agreed to purchase from the Company, up to an aggregate of
18,971,136 shares of the Company’s common stock, par value $0.001 per share (the “Common Stock”), upon the terms and conditions set forth in that certain Common Stock Purchase Agreement, dated of even date herewith, by and
among the Company and the Investors (the “Purchase Agreement”). As a condition to the closing of the transactions contemplated by the Purchase Agreement (the “Closing”), the officers, directors and existing
stockholders of the Company are required to become counterparties to this Agreement as Existing Stockholders and Stockholders. 

AGREEMENT 

1. Shelf Registration. So long as any Registrable Shares are outstanding, the Company shall take the following actions: 

(a) The Company shall, as soon as practicable but in any event by the Filing Deadline, file with the Securities and Exchange
Commission (the “Commission”), and thereafter use its reasonable best efforts to cause to be declared effective as soon as practicable, an initial registration statement (the “Shelf Registration Statement”) on an
appropriate form under the Securities Act relating to the offer and sale of the Registrable Shares by the Holders thereof from time to time in accordance with the methods of distribution set forth in the Shelf Registration Statement and Rule 415
under the Securities 

 
Act (hereinafter, the “Shelf Registration”). Such Shelf Registration Statement shall include the plan of distribution attached hereto as Exhibit B, as may be modified
in response to any comments received from the Commission. 
 Notwithstanding the foregoing, if the Commission prevents the
Company from including any or all of the Registrable Shares on the initial Shelf Registration Statement due to limitations on the use of Rule 415 of the Securities Act for the resale of the Registrable Shares by the Holders (a “Rule 415
Limitation”), the initial Shelf Registration Statement shall register the resale of a number of shares of Common Stock which is equal to the maximum number of shares as is permitted by the Commission, and, subject to the provisions of this
Section 1(a), the Company shall continue to use its reasonable best efforts to register all remaining Registrable Shares as set forth in this Section 1. In such event, the Registrable Shares to be registered pursuant to
the initial Shelf Registration Statement that were originally issued pursuant to the Purchase Agreement shall be included prior to any other Registrable Shares, provided, however, that, in accordance with the foregoing, the number of
shares to be included that were Outstanding Capital Stock shall be reduced pro rata among the Registrable Shares that were Outstanding Capital Stock and the number of shares to be included that were originally issued pursuant to the
Purchase Agreement shall be reduced pro rata among the Registrable Shares that were originally issued pursuant to the Purchase Agreement. The Company shall continue to use its reasonable best efforts to register all remaining
Registrable Shares as promptly as practicable in accordance with the applicable rules, regulations and guidance of the Commission, but in no event will the Company be required to file a subsequent Shelf Registration Statement with respect to the
registration of the resale of Registrable Shares held by the Holders earlier than 180 calendar days following the effective date of the initial Shelf Registration Statement. Notwithstanding anything herein to the contrary, if the Commission, by
written comment, limits the Company’s ability to file, or prohibits or delays the filing of, a Shelf Registration Statement with respect to any or all the Registrable Shares which were not included in the initial Shelf Registration Statement (a
“Subsequent Shelf Limitation”), the Company’s compliance with such limitation, prohibition or delay solely to the extent of such limitation, prohibition or delay shall not be a breach or default by the Company under this
Agreement and shall not be deemed a failure by the Company to use “reasonable efforts,” “reasonable best efforts” or “best efforts” as set forth above or elsewhere in this Agreement and shall not require the payment of
any liquidated damages by the Company under this Agreement (including pursuant to Section 1(d)). Unless otherwise specifically stated herein, the term “Shelf Registration Statement” shall refer individually to the initial
Shelf Registration Statement and to each subsequent Shelf Registration Statement, if any. 
 (b) The Company shall use its
reasonable best efforts to keep the Shelf Registration Statement continuously effective, in order to permit the prospectus included therein to be lawfully delivered by the Holders of the Registrable Shares included therein, until the earlier of
(i) the date on which all Registrable Shares cease to be Registrable Shares and (ii) the later of the third anniversary of the date (A) the Shelf Registration Statement is declared effective and (B) all Registrable Shares held by
Holders who have delivered a Notice and Questionnaire to the Company in accordance with Section 3(a) have been registered pursuant to the Shelf Registration Statement to the extent required by Section 1(a) (such period being
called the “Shelf Registration Period”). The Company shall be 

 
deemed not to have used its reasonable best efforts to keep the Shelf Registration Statement effective during the Shelf Registration Period if it voluntarily takes, or fails to take, any action
that would directly result in Holders of Registrable Shares covered thereby not being able to offer and sell such Registrable Shares during such period, unless such action is required by applicable law or except as provided
in Section 3(h). 
 (c) Notwithstanding any other provisions of this Agreement to the contrary, the Company
shall cause (i) the Shelf Registration Statement (as of the effective date of the Shelf Registration Statement), any amendment thereof (as of the effective date thereof) or supplement thereto (as of its date), (A) to comply in all material
respects with the applicable requirements of the Securities Act and the rules and regulations of the Commission and (B) not to contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or
necessary in order to make the statements therein not misleading, and (ii) any related prospectus, preliminary prospectus or Free Writing Prospectus and any amendment thereof or supplement thereto, as of its date, (A) to comply in all
material respects with the applicable requirements of the Securities Act and the rules and regulations of the Commission and (B) not to contain any untrue statement of a material fact or omit to state a material fact required to be stated
therein or necessary in order to make the statements therein, in light of the circumstances under which they were made, not misleading; provided, however, the Company shall have no such obligations or liabilities with respect to any
written information pertaining to any Holder and furnished to the Company by or on behalf of such Holder specifically for inclusion therein. 

(d) If (i) the initial Shelf Registration Statement is not filed by the Filing Deadline, (ii) the initial Shelf
Registration Statement is not declared effective by the Effectiveness Deadline, or (iii) the Company suspends (other than as permitted pursuant to Section 3(h)(iv) or as required to satisfy a request under Section 3(a))
or terminates the Shelf Registration Statement prior to the expiration of the Shelf Registration Period, and such suspension or termination, alone exceeds 30 consecutive days, or when taken together with all other suspensions during the preceding
12-month period, if any, exceeds 60 days in the aggregate (the “Permissible Deferral Period”), then in each such case the Company will make pro rata payments to each Investor that continues to hold Registrable Shares, as
liquidated damages and not as a penalty, in an amount equal to 1.0% of the aggregate purchase price paid by such Investor to acquire the Registrable Shares issued pursuant to the Purchase Agreement then held by such Investor for each 30-calendar day
period (or pro rata portion thereof) following (A) the Filing Deadline through and until the Company shall have filed the initial Shelf Registration Statement with the Commission, (B) the Effectiveness Deadline through and
until the initial Shelf Registration Statement is declared effective, or (C) any Permissible Deferral Period during which the Shelf Registration Statement is unavailable (for the purposes of this paragraph, each such period shall be referred to
as a “Blackout Period” for the Shelf Registration Statement); provided, however, that in no event shall the aggregate liquidated damages payable by the Company to any Investor exceed 5% of the aggregate purchase price
paid by such Investor for all Common Stock acquired by such Investor pursuant to the Purchase Agreement (for the avoidance of doubt, if an Investor holds Registrable Shares initially issued pursuant to the Purchase Agreement and also holds
Registrable Shares that were Outstanding Capital Stock, then only the Registrable Shares issued pursuant to the Purchase Agreement and 

 
not any Registrable Shares that were Outstanding Capital Stock shall be subject to the damages set forth in this Section 1(d)). The amounts payable as liquidated damages pursuant
to this paragraph shall be paid in lawful money of the United States within three (3) Business Days of the last day of each 30-calendar day period following the commencement of a Blackout Period until the termination of such Blackout Period.

 2. Additional Registration Rights. Until the effective date of the Shelf Registration Statement for all Investors and,
following such effective date and during the Shelf Registration Period, for any Investor only at such time and to the extent any Registrable Shares then held by such Investor are not registered pursuant to the Shelf Registration Statement (or the
Shelf Registration Statement is otherwise unavailable) for any reason other than such Investor’s failure to deliver a Notice and Questionnaire to the Company in accordance with Section 3(a) or a Rule 415 Limitation, the Investors
(as applicable) shall have additional rights with respect to any Registrable Shares, as follows (for clarity, as used in this Section 2, (i) any reference to “Holder,” “Holders,” “Investor,”
“Investors” and “Institutional Investors” shall apply only to any such parties that are entitled to registration rights pursuant to this Section 2 at the applicable time, and (ii) any reference to
“Registrable Shares” shall apply only to any Registrable Shares to which the registration rights pursuant to this Section 2 apply at the applicable time): 

(a) Form S-3 Demand Registration. 

(i) If at any time when it is eligible to use a Form S-3 registration statement, the Company receives a request from
Institutional Investors holding at least a majority of the Registrable Shares issued to the Institutional Investors in the Offering then outstanding that the Company file a Form S-3 registration statement covering at least 20% of the
outstanding Registrable Shares of such Institutional Investors (the “Initiating Holders”), then the Company shall (i) within ten (10) days after the date such request is given, give a notice (a “Demand
Notice”) to all Investors other than the Initiating Holders; and (ii) as soon as reasonably practicable, and in any event within forty five (45) days after the date such request is given by the Initiating Holders, file a Form S-3
registration statement under the Securities Act covering all Registrable Shares requested to be included in such registration by such Investors, as specified by notice given by each such Investor to the Company within twenty (20) days of the
date the Demand Notice is given, and in each case, subject to the limitations set forth in Sections 2(a)(ii) and (iii) and Section 2(c). 

(ii) Notwithstanding the foregoing obligations, if the Company furnishes to Investors requesting a registration pursuant
to Section 2(a)(i) a certificate signed by the Company’s chief executive officer stating that in the good faith judgment of the Company’s board of directors it would be materially detrimental to the Company and its
stockholders for such registration statement to either become effective or remain effective for as long as such registration statement otherwise would be required to remain effective, because such action would (A) materially interfere with a
significant acquisition, corporate reorganization, or other similar transaction involving the Company, (B) require premature disclosure of material information that the Company has a bona fide business purpose for preserving as confidential, or
(C) render the Company unable to comply with requirements under the Securities Act or Exchange Act, then the Company shall have the right to defer taking action 

 
with respect to such filing, and any time periods with respect to filing or effectiveness thereof shall be tolled correspondingly, for a period of not more than ninety
(90) days; provided, however, that the Company may not invoke this right more than once in any twelve (12) month period. 

(iii) The Company shall not be obligated to effect, or to take any action to effect, any registration pursuant
to Section 2(a)(i): (A) during the period that is thirty (30) days before the Company’s good faith estimate of the date of filing of, and ending on the date that is ninety (90) days after the effective date of, a
Company-initiated registration other than an Excluded Registration, provided that the Company is actively employing in good faith commercially reasonable efforts to cause such registration statement to become effective; or
(B) if the Company has effected two (2) registrations pursuant to Section 2(a)(i) within the twelve (12) month period immediately preceding the date of such request. A registration shall not be counted as
“effected” for purposes of this Section 2(a)(iii) until such time as the applicable registration statement has been declared effective by the Commission, unless the Initiating Holders withdraw their request for such
registration, in which case such withdrawn registration statement shall be counted as “effected” for purposes of this Section 2(a)(iii); provided that if, at the time of such withdrawal, the Investors
shall have learned of a material adverse change in the condition, business, or prospects of the Company from that known to the Investors at the time of their request and have withdrawn the request with reasonable promptness after learning of such
information, then such withdrawn registration statement shall not be deemed “effected” for purposes hereof. 

(b) Piggyback Registration Rights. If the Company proposes to register any of its Common Stock in a firm commitment
underwritten offering, the Company shall, at such time, promptly give each Investor notice of such registration. Upon the request of each Investor given within fifteen (15) days after such notice is given by the Company, the Company shall,
subject to the provisions of Section 2(c), cause to be registered all of the Registrable Shares that each such Investor has requested to be included in such registration. The Company shall have the right to terminate or withdraw any
registration initiated by it under this Section 2(b) before the effective date of such registration, whether or not any Investor has elected to include Registrable Shares in such registration. 

(c) Underwriting Requirements. The Company shall not be required to include any of the Holders’ Registrable
Shares in an underwritten offering under Section 2(a) or 2(b) hereof unless the Holders accept the terms of the underwriting as agreed upon between the Company and its underwriters, and then only in such quantity as the
underwriters in their sole discretion determine will not jeopardize the success of the offering by the Company. If the total number of securities, including Registrable Shares, requested by Holders to be included in such offering exceeds the number
of securities to be sold (other than by the Company) that the underwriters in their reasonable discretion determine is compatible with the success of the offering, then the Company shall be required to include in the offering only that number of
such securities, including Registrable Shares, which the underwriters and the Company in their sole discretion determine will not jeopardize the success of the offering. If the underwriters determine that less than all of the Registrable Shares
requested to be registered can be included in such offering, then the Registrable 

 
Shares that are included in such offering shall be allocated among the selling Holders in proportion (as nearly as practicable to) the number of Registrable Shares owned by each selling Holder or
in such other proportions as shall mutually be agreed to by all such selling Holders. Notwithstanding the foregoing, in no event shall the number of Registrable Shares included in the offering that are held by Investors be reduced unless all other
securities (other than securities to be sold by the Company) are subject to a comparable pro rata cutback. For purposes of the provision in this Section 2(c) concerning apportionment, for any selling Holder that is a partnership,
limited liability company, or corporation, the partners, members, retired partners, retired members, stockholders, and Affiliates of such Holder, shall be deemed to be a single “selling Holder,” and any pro rata reduction with respect to
such “selling Holder” shall be based upon the aggregate number of Registrable Shares owned by all Persons included in such “selling Holder,” as defined in this sentence. Notwithstanding the foregoing, in the event of an
underwritten public offering pursuant to which Holders of Registrable Shares request participation pursuant to Section 2(b) hereof within one year after the date hereof, the Registrable Shares to be registered pursuant to such piggy back
rights that were originally issued pursuant to the Purchase Agreement shall be included prior to any other Registrable Shares and, in accordance with the foregoing, the number of shares to be included that were Outstanding Capital Stock shall be
reduced pro rata among the Registrable Shares that were Outstanding Capital Stock and the number of shares to be included that were originally issued pursuant to the Purchase Agreement shall be reduced pro rata among the Registrable
Shares that were originally issued pursuant to the Purchase Agreement. 
 (d) Incorporation of Other Rights and
Obligations under this Agreement. The rights and obligations of the Company and the Holders pursuant to Sections 3 through 8 of this Agreement shall apply with respect to this Section 2 as if the registration statement filed
by the Company pursuant to this Section 2 was a Shelf Registration Statement. 
 3. Registration Procedures. In
connection with the Shelf Registration contemplated by Section 1 hereof, the following provisions shall apply: 

(a) At the time the Commission declares the Shelf Registration Statement effective, each Holder shall be named as a selling
stock holder in the Shelf Registration Statement and the related prospectus in such a manner as to permit such Holder to deliver such prospectus to purchasers of Registrable Shares included in the Shelf Registration Statement in accordance with
applicable law, subject to the terms and conditions hereof; provided, however, that the Company agrees to name as a selling stockholder in the Shelf Registration Statement only each Holder from which the Company has received a
Notice and Questionnaire in the form attached hereto as Exhibit C (a “Notice and Questionnaire”), on or prior to the third (3rd) Business Day before the
effective date of the Shelf Registration Statement. From and after the date the Shelf Registration Statement is declared effective, any Institutional Investor not named as a selling stockholder in the Shelf Registration Statement at the time of
effectiveness and who completes a Notice and Questionnaire may request that the Company amend or supplement the Shelf Registration Statement to include such Institutional Investor as a selling stockholder, and the Company shall, as promptly as
practicable and in any event upon the later of (x) five (5) Business Days after such date or (y) five (5) Business Days after the expiration of any Deferral 

 
Period (as defined in Section 3(h)) that is either in effect or put into effect within five (5) Business Days of such date: 

(i) if required by applicable law, prepare and file with the Commission a post-effective amendment to the Shelf Registration
Statement or prepare and, if required by applicable law, file a supplement to the related prospectus or a supplement or amendment to any document incorporated therein by reference or file with the Commission any other required document so that the
Institutional Investor is named as a selling stockholder in the Shelf Registration Statement and the related prospectus in such a manner as to permit such Institutional Investor to deliver such prospectus to purchasers of such Institutional
Investor’s Registrable Shares included in the Shelf Registration Statement in accordance with applicable law and, if the Company shall file a post-effective amendment to the Shelf Registration Statement, use its reasonable best efforts to cause
such post-effective amendment to be declared effective under the Securities Act as promptly as is practicable; 
 (ii)
provide such Holder copies of any documents filed pursuant to Section 3(a)(i); and 
 (iii) notify such
Institutional Investor as promptly as practicable after the effectiveness under the Securities Act of any post-effective amendment filed pursuant to Section 3(a)(i); 

provided, that if the request by such Institutional Investor is delivered during a Deferral Period, the Company shall so inform the
Institutional Investor making such request and shall take the actions set forth in clauses (i), (ii) and (iii) above upon expiration of the Deferral Period in accordance with
this Section 3(a) and Section 3(h) of this Agreement. 
 (b) The Company shall
notify the Holders of the Registrable Shares included within the coverage of the Shelf Registration Statement (which notice may, at the discretion of the Company (or as required pursuant to Section 3(h)), state that it constitutes a
Deferral Notice, in which event the provisions of Section 3(h) shall apply): 
 (i) when the Shelf
Registration Statement or any amendment thereto has been filed with the Commission and when the Shelf Registration Statement or any post-effective amendment thereto has become effective; 

(ii) of any request by the Commission for amendments or supplements to the Shelf Registration Statement or the prospectus
included therein or for additional information; 
 (iii) of the issuance by the Commission of any stop order suspending the
effectiveness of the Shelf Registration Statement or the initiation of any proceedings for that purpose and of any other action, event or failure to act that would cause the Shelf Registration Statement not to remain effective; 

(iv) of the receipt by the Company of any notification with respect to the suspension of the qualification or exemption from
qualification of any Registrable Shares for sale in any jurisdiction or the initiation of any proceeding for such purpose; and 

(v) of the occurrence of any Material Event (as defined in Section 3(h)). 

 Any notice delivered in connection with any of the events described in
Sections 3(b)(i) through (iv) shall include copies of any written correspondence or other documents received by the Company from the Commission or any other regulatory body (including any exchange upon which the
Registrable Shares are then traded) relating thereto. 
 (c) The Company shall use its reasonable best efforts to obtain the
withdrawal at the earliest possible time of any stop order suspending the effectiveness of the Shelf Registration Statement and the elimination of any other impediment to the continued effectiveness of the Shelf Registration Statement. 

(d) The Company shall promptly furnish to each Holder of Registrable Shares included within the coverage of the Shelf
Registration Statement, without charge, if the Holder so requests in writing, conformed copies of the Shelf Registration Statement and any post-effective amendment thereto, including financial statements and schedules and all exhibits thereto
(including those, if any, incorporated by reference). 
 (e) The Company shall promptly deliver to each Holder of Registrable
Shares included within the coverage of the Shelf Registration Statement, without charge, ten (10) copies of the prospectus (including each preliminary prospectus) included in the Shelf Registration Statement and any amendment thereof or
supplement thereto and any Free Writing Prospectus used in connection therewith as such Holder may reasonably request. The Company consents, subject to the provisions of this Agreement and except during such periods that a Deferral Notice is
outstanding and has not been revoked, to the use of the prospectus and each amendment or supplement thereto used in connection therewith by each of the selling Holders in connection with the offering and sale of the Registrable Shares covered by the
prospectus, or any amendment or supplement thereto, included in the Shelf Registration Statement. 
 (f) The Company shall
use reasonable efforts to register or qualify, or cooperate with the Holders of the Registrable Shares included in the Shelf Registration Statement and their respective counsel in connection with the registration or qualification of, the resale of
the Registrable Shares under the securities or “blue sky” laws of such states of the United States as any Holder requests in writing and to do any and all other acts or things necessary or advisable to enable the offer and sale in such
jurisdictions of the Registrable Shares covered by the Shelf Registration Statement; provided, however, that the Company shall not be required to (i) qualify generally to do business in any jurisdiction where it is not then so
qualified or (ii) take any action that would subject it to general service of process or to taxation in any jurisdiction to which it is not then so subject. 

(g) The Company shall, at its sole expense, upon notice from any Holder of Registrable Shares timely prepare and deliver
certificates representing the Registrable Shares to be delivered to a transferee pursuant to the Shelf Registration Statement, which certificates shall be free of any restrictive legends and in such denominations and registered in such names as the
Holders may request. 
 (h) Upon (i) the issuance by the Commission of a stop order suspending the effectiveness of the
Shelf Registration Statement or the initiation of proceedings with respect to the Shelf Registration Statement under Section 7(d) or 7(e) of the Securities Act, (ii) the occurrence of any event or the existence of any fact (a
“Material Event”) as a result of which (x) the Shelf Registration Statement shall contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to

 
make the statements therein not misleading or (y) any prospectus included in the Shelf Registration Statement shall contain any untrue statement of a material fact or omit to state any
material fact required to be stated therein or necessary to make the statements therein, in the light of the circumstances under which they were made, not misleading, (iii) the occurrence or existence of any pending corporate development that,
in the reasonable judgment of the Company, makes it necessary to suspend the availability of the Shelf Registration Statement and the related prospectus for a period of time, or (iv) the Company’s having filed a document pursuant to
Section 13(a), 13(c), 14 or 15(d) of the Exchange Act that, in the reasonable judgment of the Company, must be included in the Shelf Registration Statement pursuant to a post-effective amendment to the Shelf Registration Statement or supplement
to the related prospectus (any such document, an “Exchange Act Report”): 
 (A) in the case of clause
(ii) above, subject to clause (C) below, as promptly as practicable, the Company shall prepare and file, if necessary pursuant to applicable law, a post-effective amendment to the Shelf Registration Statement or a supplement to the related
prospectus or any document incorporated therein by reference or file any other required document that would be incorporated by reference into the Shelf Registration Statement and related prospectus so that (1) the Shelf Registration Statement
does not contain any untrue statement of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein not misleading and (2) such prospectus does not contain any untrue statement
of a material fact or omit to state any material fact required to be stated therein or necessary to make the statements therein, in light of the circumstances under which they were made, not misleading, as thereafter delivered to the purchasers of
the Registrable Shares being sold thereunder, and, in the case of a post-effective amendment to the Shelf Registration Statement, subject to the next sentence, use reasonable best efforts to cause it to be declared effective as promptly as is
practicable; 
 (B) in the case of clause (iv) above, subject to clause (C) below, as promptly as practicable, but
in no event more than five (5) Business Days, following the Company’s filing of an Exchange Act Report, the Company shall prepare and file, if necessary, pursuant to applicable law, a post-effective amendment to the Shelf Registration
Statement or a supplement to the related prospectus incorporating by reference the Exchange Act Report into the Shelf Registration Statement or including within such post-effective amendment or supplement the information contained in the related
Exchange Act Report; and 
 (C) the Company shall give notice to the Holders with respect to the Shelf Registration
Statement, that the availability of the Shelf Registration Statement is suspended (a “Deferral Notice”) and, upon receipt of any Deferral Notice, each Holder agrees not to sell any Registrable Shares pursuant to the Shelf
Registration Statement until such Holder’s receipt of copies of the supplemented or amended prospectus provided for in clause (A) or (B) above, or until it is advised in writing by the Company that the prospectus may be used, and has
received copies of any additional or supplemental filings that are incorporated or deemed incorporated by reference in such prospectus. 

 The Company will use its reasonable best efforts to ensure that the use of the prospectus with
respect to the Shelf Registration Statement may be resumed (w) in the case of clause (i) above, as promptly as is practicable, (x) in the case of clause (ii) above, as soon as, in the reasonable judgment of the Company, public
disclosure of such Material Event would not be prejudicial to or contrary to the material interests of the Company, (y) in the case of clause (iii) above, as soon as, in the reasonable judgment of the Company, such suspension is no longer
necessary; provided, that in no event shall (A) any suspension arising from events described in clauses (ii) and (iii) above exceed 30 days, (B) the aggregate duration of all suspensions arising from events described
in clauses (ii) and (iii) above exceed 60 days in any 12-month period, or (C) a suspension arising from an event described in clause (ii) or clause (iii) above be invoked more than twice in any 12-month period or arise
within thirty (30) days after the termination of a previous suspension, and (z) in the case of clause (iv) above, as soon as practicable following the filing of the Exchange Act Report, but in no event sooner than the Commission has
declared the post-effective amendment, if applicable, effective. Any such period during which the availability of the Shelf Registration Statement and any related prospectus is suspended is referred to as the “Deferral Period.” 

(i) The Company will comply with all rules and regulations of the Commission to the extent and so long as they are applicable
to the Shelf Registration and will make generally available to its security holders (or otherwise provide in accordance with Section 11(a) of the Securities Act) an earnings statement (which need not be audited) satisfying the provisions of
Section 11(a) of the Securities Act and Rule 158 thereunder, no later than forty-five (45) days after the end of a 12-month period (or ninety (90) days, if such period is a fiscal year) beginning with the first month of the
Company’s first fiscal quarter commencing after the effective date of the Shelf Registration Statement, which statement shall cover such 12-month period. 

(j) If requested in writing in connection with a disposition of Registrable Shares pursuant to the Shelf Registration
Statement, the Company shall make reasonably available for inspection during normal business hours by a representative for the Holders of a majority of the number of such Registrable Shares or any individual Institutional Investor that so requests,
any broker-dealers, attorneys and accountants retained by such holders, and any attorneys or other agents retained by a broker-dealer engaged by such Holders, all relevant financial and other records and pertinent corporate documents and properties
of the Company and its subsidiaries, and cause the appropriate officers, directors and employees of the Company and its subsidiaries to make reasonably available for inspection during normal business hours on reasonable notice all relevant
information reasonably requested by such representative for the Holders or any individual Institutional Investor, or any such broker-dealers, attorneys or accountants in connection with such disposition, in each case as is customary for similar
“due diligence” examinations; provided, that such persons shall first agree in writing with the Company that any information that is reasonably and in good faith designated by the Company in writing as confidential at the time of
delivery of such information shall be kept confidential by such persons and shall be used solely for the purposes of exercising rights under this Agreement, unless (i) disclosure of such information is required by court or administrative order
or is necessary to respond to inquiries of regulatory authorities, (ii) disclosure of such information is required by law (including any disclosure 

 
requirements pursuant to federal securities laws in connection with the filing of the Shelf Registration Statement or the use of any prospectus or Free Writing Prospectus referred to in this
Agreement) or (iii) such information becomes generally available to the public other than as a result of a disclosure or failure to safeguard by any such person, and provided further that the foregoing inspection and information gathering
shall, to the greatest extent possible, be coordinated on behalf of all the Holders and the other parties entitled thereto by one legal counsel designated by the Lead Investor and reasonably acceptable to the Company (a “Lead Investor
Counsel”). 
 (k) The Company shall (i) permit such Lead Investor Counsel to review and comment upon
(A) the Shelf Registration Statement at least five (5) Business Days prior to its filing with the Commission and (B) all Free Writing Prospectuses and all amendments and supplements to the Shelf Registration Statement within a
reasonable number of days, but in any event not less than two (2) Business Days, prior to their filing with the Commission, and (ii) not file the Shelf Registration Statement or amendment thereof or supplement thereto or any Free Writing
Prospectus in a form to which such Lead Investor Counsel reasonably objects. The Company shall furnish to such Lead Investor Counsel, without charge, (x) copies of any correspondence from the Commission or the staff of the Commission to the
Company or its representatives relating to the Shelf Registration Statement or any document incorporated by reference therein, (y) promptly after the same is prepared and filed with the Commission, one copy of the Shelf Registration Statement
and any amendment(s) thereto, including financial statements and schedules, all documents incorporated therein by reference, if requested by a Holder, and all exhibits thereto; and (z) promptly upon the effectiveness of the Shelf Registration
Statement, one copy of the prospectus included in the Shelf Registration Statement and all amendments and supplements thereto. The Company shall reasonably cooperate with such Lead Investor Counsel in performing the Company’s obligations
pursuant to this Section 3. 
 (l) If requested by a Holder, the Company shall as soon as practicable
(i) incorporate in a prospectus supplement or post-effective amendment such information as such Holder requests to be included therein relating to the sale and distribution of Registrable Shares, including, without limitation, information with
respect to the number of Registrable Shares being offered or sold, the purchase price being paid therefor and any other terms of the offering of the Registrable Shares to be sold in such offering; (ii) make all required filings of such
prospectus supplement or post-effective amendment after being notified of the matters to be incorporated in such prospectus supplement or post-effective amendment; and (iii) supplement or make amendments to any Shelf Registration Statement if
reasonably requested by a Holder holding any Registrable Shares. 
 4. Holder’s Obligations; Lock-Up Agreements. 

(a) Shelf Registration Statement. Each Holder agrees that no Holder of Registrable Shares shall be entitled to sell
any of such Registrable Shares pursuant to the Shelf Registration Statement or to receive a prospectus relating thereto, unless such Holder has furnished the Company with a Notice and Questionnaire as required pursuant
to Section 3(a) hereof (including the information required to be included in such Notice and Questionnaire) and the information set forth in the next sentence, unless the Company in its sole discretion determines to
include the Registrable Shares in the Shelf 

 
Registration after receiving similar information as would be contained in the Notice and Questionnaire from sources that it deems to be reliable. Each such Holder agrees promptly to furnish to
the Company all information required to be disclosed in order to make the information previously furnished to the Company by such Holder not misleading and any other information regarding such Holder and the distribution of such Registrable Shares
as may be required to be disclosed in the Shelf Registration Statement under applicable law or pursuant to Commission comments. Each Holder further agrees not to sell any Registrable Shares pursuant to the Shelf Registration Statement without
delivering, or causing to be delivered, the prospectus included in such Shelf Registration Statement to the purchaser thereof (or otherwise delivering such a prospectus in accordance with applicable law). 

(b) Full Lock-Up Agreement of the Existing Stockholders.

(i) Subject to Section 4(b)(ii), each Existing Stockholder hereby agrees that, for a period (the “Lock-Up
Period”) beginning on the Closing and ending on the later of (i) 180 calendar days after the date on which the Zeta common stock is listed for trading on the New York Stock Exchange, the NYSE-Mkt, or the NASDAQ Stock Market (each a
“National Exchange”) or (ii) twelve (12) months after the Closing, such Existing Stockholder shall not sell, transfer, dispose of, contract to sell, sell any option or contract to purchase, or otherwise transfer or dispose
of, directly or indirectly, any shares of Zeta common stock beneficially owned by such Existing Stockholder or any securities convertible into or exercisable or exchangeable therefor (collectively, the “Existing Stockholder Restricted
Shares”); provided, however, that Section 4(c) and not this Section 4(b) shall apply to any shares of Zeta common stock that are issued in the Merger in exchange for shares of Common Stock acquired by an
Existing Stockholder pursuant to the Purchase Agreement. Notwithstanding the foregoing, the Existing Stockholders may exchange the shares of Common Stock beneficially owned by them for shares of Zeta common stock pursuant to the Merger. 

(ii) Notwithstanding Section 4(b)(i), and subject to the conditions below, following the Merger, an Existing
Stockholder may transfer his, her or its Existing Stockholder Restricted Shares, provided that each donee, trustee, distributee, or transferee, as the case may be (except in the case of clause (E)), signs an Adoption Agreement or other instrument
agreeing to the provisions of Section 4(b) hereof: 
 (A) as a bona fide gift or gifts; 

(B) to any immediate family member of the Existing Stockholder or any trust for the direct or indirect benefit of the Existing
Stockholder or the immediate family of the Existing Stockholder (for purposes hereof, “immediate family” shall mean any relationship by blood, marriage or adoption, not more remote than first cousin); 

(C) by operation of law, including domestic relations orders; 

(D) by testate succession or intestate distribution; 

 (E) as a forfeiture of shares of Zeta common stock or other securities solely to
Zeta in a transaction exempt from Section 16(b) of the Exchange Act in connection with the payment of taxes due upon the exercise of options to purchase Zeta common stock or vesting of other securities pursuant to any Company or Zeta employee
benefit plan; 
 (F) as a distribution to limited partners, members, stockholders or other securityholders of the Existing
Stockholder (or their equivalents under the jurisdiction of organization of the Existing Stockholder) or, if the Existing Stockholder is a trust, to the beneficiaries of the Existing Stockholder; or 

(G) to the Existing Stockholder’s affiliates or to any investment fund or other entity controlled or managed by, or under
common control or management by, the Existing Stockholder. 
 Furthermore, during the Lock-Up Period, each Existing
Stockholder may (x) sell shares of Zeta common stock purchased by the Existing Stockholder on the open market or in connection with any follow-on securities offering by Zeta after the Merger (subject to any lock-up agreement that may be entered
into in connection with such offering), (y) exercise any stock options granted pursuant to the Company’s or Zeta’s equity incentive plans or warrants to purchase Zeta common stock, so long as the shares of Zeta common stock received
upon such exercise shall remain subject to the terms of Section 4(b) of this Agreement, or (z) establish a contract, instruction or plan (a “Rule 10b5-1 Plan”) that complies with the requirements of Rule
10b5-1(c)(1) under the Exchange Act at any time during the Lock-Up Period (provided that, during the Lock-Up Period, the Existing Stockholder shall not transfer any of the Zeta common stock or other securities under such Rule 10b5-1 Plan except as
provided herein). 
 (c) Limited Lock-Up Agreement of the Investors. Each Investor hereby agrees that, for a
period beginning on the date of the Closing and ending on the earlier of (i) the date on which the Zeta common stock is listed on the OTC Bulletin Boards, OTCQB, OTCQX or a National Exchange and (ii) 180 calendar days following the date of
the Closing, such Investor shall not sell, transfer, dispose of, contract to sell, sell any option or contract to purchase, or otherwise transfer or dispose of, directly or indirectly, any shares of Zeta common stock as are issued in the Merger (the
“Investor Restricted Shares”) and beneficially owned by such Investor or any securities convertible into or exercisable or exchangeable for such Investor Restricted Shares. In addition, each Investor that is not an Institutional
Investor shall continue to hold at least one hundred (100) Investor Restricted Shares until the Zeta common stock is listed on a National Exchange. Notwithstanding the foregoing, (i) the Investors may exchange the shares of Common Stock
beneficially owned by them for shares of Zeta common stock pursuant to the Merger, and (ii) following the Merger, an Institutional Investor may transfer the Investor Restricted Shares held by such Institutional Investor (provided that each
trustee, distributee or transferee, as the case may be, signs an Adoption Agreement or other instrument agreeing to the provisions of this Section 4(c)): (x) as a distribution to limited partners, members, stockholders or other
securityholders of the Institutional Investor (or 

 
their equivalents under the jurisdiction of organization of the Institutional Investor) or, if the Institutional Investor is a trust, to the beneficiaries of the Institutional Investor; or
(y) to the Institutional Investor’s affiliates or to any investment fund or other entity controlled or managed by, or under common control or management by, the Institutional Investor. Any discretionary waiver or termination of the lock-up
restrictions set forth in this Section 4(c) by the Company or any underwriter shall apply pro rata to all Investors subject to such restrictions, based on the number of shares subject to such agreements. 

(d) Securities Law Compliance. The Holders will not make any transfer or disposition of any of the Registrable
Shares except in compliance with the Securities Act or pursuant to an exemption therefrom. 
 5. Registration Expenses. 

(a) All fees and expenses incident to the Company’s performance of and compliance with this Agreement will be borne by the
Company, regardless of whether the Shelf Registration Statement is ever filed or becomes effective, including without limitation: 

(i) all registration and filing fees and expenses; 

(ii) all fees and expenses of compliance with federal securities and state “blue sky” or securities laws; 

(iii) all expenses of printing (including, without limitation, printing certificates and prospectuses), messenger and delivery
services and telephone; 
 (iv) all fees and disbursements of counsel for the Company; 

(v) all application and filing fees in connection with listing on a national securities exchange or automated quotation system
pursuant to the requirements hereof; and 
 (vi) all fees and disbursements of independent certified public accountants of
the Company (including, without limitation, the expenses of any special audit required by or incident to such performance). 
 The Company
will bear its internal expenses (including, without limitation, all salaries and expenses of its officers and employees performing legal or accounting duties), the expenses of any annual audit and the fees and expenses of any person, including
special experts, retained by the Company. 
 (b) In connection with the filing of the Shelf Registration Statement, the
Company will reimburse the reasonable fees and disbursements of the Lead Investor Counsel, such amount not to exceed $25,000. In connection with the filing of one or more registration statements in compliance with Section 2 hereof, the
Company will reimburse the reasonable fees and disbursements of the Lead Investor Counsel, such amount not to exceed $25,000 in the aggregate (in addition to and not including the $25,000 described in the prior sentence). The reimbursements
described in this Section 5(b) are separate from and in addition to those described in Section 7 of the Purchase Agreement. 

6. Indemnification. 

(a) The Company agrees to indemnify and hold harmless each Holder of the Registrable Shares included within the coverage of the
Shelf Registration Statement, the 

 
directors, officers, employees, Affiliates and agents of each such Holder and each person who controls any such Holder within the meaning of the Securities Act or the Exchange Act (collectively,
the “Holder Indemnified Parties”) from and against any losses, claims, damages or liabilities, joint or several, or any actions in respect thereof to which each Holder Indemnified Party may become subject under the Securities Act or
the Exchange Act, insofar as such losses, claims, damages, liabilities or actions arise out of or are based upon (i) any untrue statement or alleged untrue statement of a material fact contained in the Shelf Registration Statement or in any
amendment thereof, in each case at the time such became effective under the Securities Act, or in any Disclosure Package, prospectus or in any amendment thereof or supplement thereto, or (ii) the omission or alleged omission to state therein a
material fact required to be stated therein or necessary to make the statements therein (in the case of the Disclosure Package or any prospectus, in the light of the circumstances under which they were made) not misleading, and shall reimburse, as
incurred, the Holder Indemnified Parties for any legal or other expenses reasonably incurred by them in connection with investigating or defending any such loss, claim, damage, liability or action in respect
thereof; provided, however, that the Company shall not be liable in any such case to the extent that such loss, claim, damage or liability arises out of or is based upon any untrue statement or omission made in the Shelf
Registration Statement, the Disclosure Package, any prospectus or in any amendment thereof or supplement thereto in reliance upon and in conformity with written information pertaining to such Holder and furnished to the Company by or on behalf of
such Holder Indemnified Party specifically for inclusion therein; provided further, however, that the Company shall not be liable in any such case to the extent that such loss, claim, damage or liability arises out of or is based upon
any untrue statement or alleged untrue statement or omission or alleged omission made in the Disclosure Package, where (i) such statement or omission had been eliminated or remedied in any subsequently filed amended prospectus, prospectus
supplement or Free Writing Prospectus (the Disclosure Package, together with such updated documents, the “Updated Disclosure Package”), the filing of which the applicable Holder had been notified in accordance with the terms of this
Agreement, (ii) such Updated Disclosure Package was available at the time the Holder sold Registrable Shares under the Shelf Registration Statement, (iii) such Updated Disclosure Package was not furnished by the Holder to the person or
entity asserting the loss, liability, claim, damage or liability at or prior to the time such furnishing is required by the Securities Act and (iv) the Updated Disclosure Package would have cured the defect giving rise to such loss, liability,
claim, damage or action; and provided further, however, that this indemnity agreement will be in addition to any liability that the Company may otherwise have to such Holder Indemnified Party. Such indemnity shall remain in
full force and effect regardless of any investigation made by or on behalf of any Holder Indemnified Parties and shall survive the transfer of the Registrable Shares by any Holder. 

(b) Each Holder of the Registrable Shares covered by the Shelf Registration Statement severally, and not jointly, agrees to
indemnify and hold harmless the Company, each of its directors, each of its officers who signs the Shelf Registration Statement, as well as any officers, employees, Affiliates and agents of the Company, and each person, if any, who controls the
Company within the meaning of the Securities Act or the Exchange Act (a “Company Indemnified Party”) from and against any losses, claims, damages or liabilities or any actions in respect thereof, to which a Company Indemnified Party
may 

 
become subject under the Securities Act or the Exchange Act, insofar as such losses, claims, damages, liabilities or actions arise out of or are based upon (i) any untrue statement or
alleged untrue statement of a material fact contained in the Shelf Registration Statement or in any amendment thereof, in each case at the time such became effective under the Securities Act, or in any Disclosure Package, prospectus or in any
amendment thereof or supplement thereto, or (ii) the omission or alleged omission to state therein a material fact required to be stated therein or necessary to make the statements therein (in the case of the Disclosure Package or any
prospectus, in the light of the circumstances under which they were made) not misleading, but in each case only to the extent that the untrue statement or omission or alleged untrue statement or omission was made in reliance upon and in conformity
with written information pertaining to such Holder and furnished to the Company by or on behalf of such Holder specifically for inclusion therein; and, subject to the limitation set forth immediately preceding this clause, shall reimburse, as
incurred, the Company Indemnified Parties for any legal or other expenses reasonably incurred by them in connection with investigating or defending any loss, claim, damage, liability or action in respect thereof. This indemnity agreement will be in
addition to any liability that such Holder may otherwise have to the Company Indemnified Parties. Notwithstanding any other provision of this Section 6(b), no Holder shall be required to indemnify or hold harmless any Company
Indemnified Party in an amount in excess of the amount by which the net proceeds received by such Holder from the sale of the Registrable Shares pursuant to the Shelf Registration Statement exceeds the amount of damages that such Holder has
otherwise been required to pay by reason of such untrue statement or omission. 
 (c) Promptly after receipt by a Holder
Indemnified Party or a Company Indemnified Party (each, an “Indemnified Party”) of notice of the commencement of any action or proceeding (including a governmental investigation), such Indemnified Party will, if a claim in respect
thereof is to be made against the indemnifying party under this Section 6, notify the indemnifying party of the commencement thereof; but the omission to so notify the indemnifying party will not relieve the indemnifying party from
liability under paragraph (a) or (b) above unless and to the extent it did not otherwise learn of such action and the indemnifying party has been materially prejudiced by such failure. In case any such action is brought against any
Indemnified Party, and it notifies the indemnifying party of the commencement thereof, the indemnifying party will be entitled to participate therein and, to the extent that it may wish, jointly with any other indemnifying party similarly notified,
to assume the defense thereof, with counsel reasonably satisfactory to such Indemnified Party (who shall not, except with the consent of the Indemnified Party, be counsel to the indemnifying party), and after notice from the indemnifying party to
such Indemnified Party of its election so to assume the defense thereof the indemnifying party will not be liable to such Indemnified Party under this Section 6 for any legal or other expenses, other than reasonable costs of
investigation, subsequently incurred by such Indemnified Party in connection with the defense thereof; provided, however, if such Indemnified Party shall have been advised by counsel that there are one or more defenses
available to it that are in conflict with those available to the indemnifying party (in which case the indemnifying party shall not have the right to direct the defense of such action on behalf of the Indemnified Party), the reasonable fees and
expenses of such Indemnified Party’s counsel shall be borne by the indemnifying party. In no event shall the 

 
indemnifying party be liable for the fees and expenses of more than one counsel (together with appropriate local counsel) at any time for any Indemnified Party in connection with any one action
or separate but substantially similar or related actions arising in the same jurisdiction out of the same general allegations or circumstances. No indemnifying party shall, without the prior written consent of the Indemnified Party (not to be
unreasonably withheld or delayed), effect any settlement of any pending or threatened action in respect of which any Indemnified Party is or could have been a party and indemnity could have been sought hereunder by such Indemnified Party unless such
settlement (i) includes an unconditional release of such Indemnified Party from all liability on any claims that are the subject matter of such action and (ii) does not include a statement as to or an admission of fault, culpability or a
failure to act by or on behalf of any Indemnified Party. 
 (d) If the indemnification provided for in
this Section 6 is unavailable or insufficient to hold harmless an Indemnified Party under subsections (a) or (b) above, then each indemnifying party shall contribute to the amount paid or payable by such Indemnified
Party as a result of the losses, claims, damages or liabilities (or actions in respect thereof) referred to in subsection (a) or (b) above in such proportion as is appropriate to reflect the relative fault of the indemnifying party or
parties on the one hand and the Indemnified Party on the other in connection with the statements or omissions that resulted in such losses, claims, damages or liabilities (or actions in respect thereof) as well as any other relevant equitable
considerations. The relative fault of the parties shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of a material fact or the omission or alleged omission to state a material fact relates to
information supplied by the Company on the one hand or the Holder or Holder Indemnified Party, as the case may be, on the other, and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such
statement or omission. The amount paid by an Indemnified Party as a result of the losses, claims, damages or liabilities referred to in the first sentence of this subsection (d) shall be deemed to include any legal or other expenses reasonably
incurred by such Indemnified Party in connection with investigating or defending any action or claim that is the subject of this subsection (d). The parties agree that it would not be just and equitable if contributions were determined
by pro rata allocation (even if the Holders were treated as one entity for such purpose) or any other method of allocation that does not take account of the equitable considerations referred to above. Notwithstanding any other
provision of this Section 6(d), no Holder shall be required to contribute any amount in excess of the amount by which the net proceeds received by such Holder from the sale of the Registrable Shares pursuant to the Shelf
Registration Statement exceeds the amount of damages that such Holder has otherwise been required to pay by reason of such untrue or alleged untrue statement or omission or alleged omission. No person guilty of fraudulent misrepresentation (within
the meaning of Section 11(f) of the Securities Act) shall be entitled to contribution from any person who was not guilty of such fraudulent misrepresentation. 

(e) The agreements contained in this Section 6 shall survive the sale of the Registrable Shares pursuant
to the Shelf Registration Statement and shall remain in full force and effect, regardless of any termination or cancellation of this Agreement or any investigation made by or on behalf of any Indemnified Party. 

 7. Information Requirements. The Company covenants that, if at any time before the end of the
applicable Shelf Registration Period, the Company is not subject to the reporting requirements of the Exchange Act, it will take such further action as may be required from time to time to enable the Holders to sell Registrable Shares without
registration under the Securities Act within the limitation of the exemptions provided by Rules 144 and 144A (including the requirements of Rule 144A(d)(4) under the Securities Act). Upon the request of any Holder of Registrable Shares, the Company
shall deliver to such Holder a written statement as to whether it has complied with such requirements. 
 8. Miscellaneous. 

(a) Recapitalizations, Exchanges, Etc. The provisions of this Agreement shall apply to the full extent set
forth herein with respect to (i) the Registrable Shares, (ii) any and all securities of the Company into which the Registrable Shares are converted, exchanged or substituted in any recapitalization or other capital reorganization by the
Company and (iii) any and all equity securities of the Company or any successor or assign of the Company (whether by merger, consolidation, sale of assets or otherwise) which may be issued in respect of, in conversion of, in exchange for or in
substitution of, the shares of Registrable Shares and shall be appropriately adjusted for any stock dividends, splits, reverse splits, combinations, recapitalizations and the like occurring after the date hereof. The Company shall cause any
successor or assign (whether by merger, consolidation, sale of assets or otherwise) to assume this Agreement or enter into a new registration rights agreement with the Holders on terms substantially the same as this Agreement as a condition of any
such transaction. 
 (b) No Inconsistent Agreements. The Company will not on or after the date of this
Agreement enter into any agreement with respect to its securities that is inconsistent with the rights granted to the Holders in this Agreement or otherwise conflicts with the provisions hereof. The rights granted to the Holders hereunder do not in
any way conflict with and are not inconsistent with the rights granted to the holders of the Company’s securities under any agreement in effect on the date hereof. Prior to the expiration of the Shelf Registration Period, without the consent of
the Institutional Investors holding a majority of then outstanding Registrable Shares held by all Institutional Investors, the Company shall not enter into any agreement with any holder or prospective holder of securities of the Company that
provides for registration rights that are pari passu or senior to those held by the Investors pursuant to this Agreement. 

(c) Interpretation. Section, Schedule, and Exhibit references are to this Agreement, unless otherwise specified.
All references to instruments, documents, contracts, and agreements are references to such instruments, documents, contracts and agreements as the same may be amended, supplemented and otherwise modified from time to time, unless otherwise
specified. The word “including” shall mean “including, without limitation.” 
 (d) Amendments and
Waivers. The provisions of this Agreement may not be amended, modified or supplemented, and waivers or consents to departures from the provisions hereof may not be given, except by the written consent of the Company and the Institutional
Investors holding a majority of then outstanding Registrable Shares held by all Institutional Investors; provided, however, that any amendment, modification or waiver of this Agreement that applies only to Existing Stockholders may be
obtained with the 

 
written consent of the Company and the Holders holding a majority of then outstanding Registrable Shares held by Existing Stockholders and the Holders of a majority of the then outstanding
Registrable Shares that were Outstanding Capital Stock and the majority of the then outstanding Registrable Shares held by all Institutional Investors; and provided further, that notwithstanding the foregoing, any amendment or
modification of or supplement to this Agreement which would materially and adversely affect any Investor in a manner that is disproportionate to the other Investors will be binding upon and enforceable against such Investor only with such
Investor’s prior written consent. Each Holder of Registrable Shares outstanding at the time of any such amendment, modification, supplement, waiver or consent or thereafter shall be bound by any such amendment, modification, supplement, waiver
or consent effected pursuant to this Section 8(d), whether or not any notice, writing or marking indicating such amendment, modification, supplement, waiver or consent appears on the Registrable Shares. Any amendment, supplement or
modification of or to any provision of this Agreement, any waiver of any provision of this Agreement, and any consent to any departure from the terms of any provision of this Agreement shall be effective only in the specific instance and for the
specific purpose for which made or given. No failure or delay on the part of any party in exercising any right, power or remedy hereunder shall operate as a waiver thereof, nor shall any single or partial exercise of any such right, power or remedy
preclude any other or further exercise thereof or the exercise of any right, power or remedy. The remedies provided for herein are cumulative and are not exclusive of any remedies that may be available to a party at law or in equity or otherwise. A
copy of each amendment, modification or supplement to this Agreement shall be delivered by the Company to each Holder within five (5) Business Days of its effectiveness; provided that no Holder will be bound by such amendment
until a copy of such amendment has been given to such Holder in accordance with Section 8(e) below. No amendment, modification or supplement to this Agreement shall be binding on any Holder until such Holder shall have received written
notice of the adoption thereof in accordance with this Section 8(d). 
 (e) Notices. All notices
and other communications provided for or permitted hereunder shall be made in writing and shall be given by registered or certified mail, return receipt requested, telecopy, air courier guaranteeing overnight delivery or personal delivery to the
following addresses: 
 (i) if to the Company (or to Zeta after the closing of the Merger), at its address as follows: 

Kura Oncology, Inc. 

11119 N. Torrey Pines Road, Ste. 125 

La Jolla, CA 92037 

Attention: Heidi Henson, Chief Financial Officer 

Telephone No.: (858) 500-8804 

E-mail: heidi@kuraoncology.com 

with a copy to: 

 Cooley LLP 

4401 Eastgate Mall 

San Diego, CA 92121 

Attention: Charles Bair 

Telephone No.: (858) 550-6142 

E-mail: cbair@cooley.com 

(ii) if to a Holder, at the most current address shown for such Holder in the records of the Company; 

or to such other address as the Company or such Holder may designate in writing. All notices and communications shall be deemed to have been
duly given: at the time delivered by hand, if personally delivered; upon actual receipt if sent by certified mail, return receipt requested, or regular mail, if mailed; when receipt acknowledged, if sent via facsimile; and upon actual receipt when
delivered to an air courier guaranteeing overnight delivery. 
 (f) Successors and Assigns. This Agreement shall
inure to the benefit of and be binding upon the successors and permitted assigns of the parties hereto as hereinafter provided. The rights of the Holders contained in this Agreement shall be automatically transferred to the transferee of any
Registrable Shares, provided, that (i) such transfer consists of at least fifty thousand (50,000) Registrable Shares (or, with respect to any Holder who initially held at least one hundred thousand (100,000) Registrable
Shares, such lesser number of shares as then held by such Holder); (ii) such transferee agrees to become a party to this Agreement and be fully bound by, and subject to, all of the terms and conditions of this Agreement as though an original
party hereto by signing an Adoption Agreement in the form attached hereto as Exhibit A; (iii) immediately following such transfer the further disposition of such securities by the transferee is restricted under the Securities Act or
applicable state securities laws if so required; and (iv) such transfer shall have been conducted in accordance with all applicable federal and state securities laws. All of the obligations of the Company hereunder shall survive any such
transfer. 
 Neither this Agreement nor any of the rights or duties of the Company set forth herein shall be assigned by the
Company, in whole or in part. Notwithstanding the foregoing, upon the consummation of the Merger and with respect to all times following the consummation of the Merger, (i) the Company shall, and hereby does, irrevocably assign all of its
rights, duties and obligations under this Agreement to Zeta and (ii) Zeta, by executing this Agreement as an anticipated successor and assign to the Company, does hereby irrevocably assume, effective upon the consummation of the Merger, all of
the Company’s rights, duties and obligations under this Agreement, including the Company’s obligation to register the Registrable Shares (the “Zeta Assignment”). All parties to this Agreement hereby consent to the
assignment and assumption contemplated between the Company and Zeta set forth in this paragraph. Further to and not in derogation of the foregoing, following the consummation of the Merger, those shares of the common stock, par value $0.001 per
share, of Zeta (“Zeta Stock”) issued to Stockholders in connection with the Merger shall constitute Registrable Shares for all purposes hereunder. For the avoidance of doubt and by way of example, the Company, the Investors and Zeta
acknowledge and agree that, as a result of the Zeta Assignment, (y) the obligation to file 

 
and keep effective the Shelf Registration Statement shall be assumed and undertaken by Zeta, and (z) the covenants regarding registration rights and indemnification of the Stockholders set
forth herein shall be binding on Zeta. 
 (g) Counterparts. This Agreement may be executed in any number of
counterparts and by different parties hereto in separate counterparts, each of which counterpart, when so executed and delivered, shall be deemed to be an original and all of which counterparts, taken together, shall constitute one and the same
agreement. 
 (h) Headings. The headings in this Agreement are for convenience of reference only and shall not
limit or otherwise affect the meaning hereof. 
 (i) Governing Law. This Agreement shall be governed by, and
construed in accordance with, the laws of the State of New York without regard to principles of conflicts of laws. 

(j) Submission to Jurisdiction. The parties to this Agreement (i) irrevocably submit to the exclusive
jurisdiction of any state or federal courts located in New York County, New York in connection with any disputes arising out of or relating to this Agreement and (ii) waive any claim of improper venue or any claim that those courts are an
inconvenient forum. The parties to this Agreement agree that mailing of process or other papers in connection with any such action or proceeding in the manner provided in Section 8(e) or in such other manner as may be permitted
by applicable laws, shall be valid and sufficient service thereof. 
 (k) Severability. If any term or other
provision of this Agreement is invalid, illegal or incapable of being enforced by virtue of any applicable law, or due to any public policy, all other conditions and provisions of this Agreement shall nevertheless remain in full force and effect so
long as the economic or legal substance of the transactions contemplated hereby is not affected in any manner materially adverse to any party. Upon such determination that any term or other provision is invalid, illegal or incapable of being
enforced, the parties hereto shall negotiate in good faith to modify this Agreement so as to effect the original intent of the parties as closely as possible in an acceptable manner so that the transactions contemplated hereby are fulfilled to the
extent possible. 
 (l) Entire Agreement. This Agreement is intended by the parties as a final expression of
their agreement and is intended to be a complete and exclusive statement of the agreement and understanding of the parties hereto in respect of the subject matter contained herein, superseding all prior agreements and understandings among the
parties with respect to such subject matter. 
 (m) Further Assurances. Each of the parties shall execute such
documents and perform such further acts as may be reasonably required or desirable to carry out or to perform the provisions of this Agreement. 

(n) Termination. This Agreement and the obligations of the parties hereunder shall terminate upon the end of the
Shelf Registration Period; provided, however, that the obligations arising under Sections 5, 6 and 7 shall remain in effect in accordance with their terms. 

(o) Securities Held by the Company. Whenever the consent or approval of Holders of a specified number of
Registrable Shares is required hereunder, shares of Common 

 
Stock held by the Company or its subsidiaries shall not be counted in determining whether such consent or approval was given by the Holders of such required percentage. 

(p) Independent Nature of Obligations. The obligations of each Investor under this Agreement are several and not
joint with the obligations of any other Investor, and no Investor shall be responsible in any way for the performance of the obligations of any other Investor under this Agreement. The failure or waiver of performance under this Agreement by any
Investor shall not excuse performance by any other Investor. Each Investor shall be entitled to independently protect and enforce its rights, including, without limitation, the rights arising out of this Agreement, and it shall not be necessary for
any other Investor to be joined as an additional party in any proceeding for such purpose. 
 (q) Definitions.
The following terms shall have the following meanings: 
 “Affiliate” means, with respect to any specified
person, an “affiliate,” as defined in Rule 144(a)(1) of the Securities Act, of such person. 

“Agreement” shall have the meaning set forth in the recitals hereto. 

“Blackout Period” shall have the meaning set forth in Section 1(d). 

“Business Day” shall mean any day other than a Saturday, Sunday or other day on which banks in the State of
New York are required or authorized to close. 
 “Closing” shall have the meaning set forth in the recitals
hereto. 
 “Commission” shall have the meaning set forth in Section 1(a). 

“Common Stock” shall have the meaning set forth in the recitals hereto. 

“Company” shall have the meaning set forth in the recitals hereto. 

“Company Indemnified Party” shall have the meaning set forth in Section 6(b). 

“Deferral Notice” shall have the meaning set forth in Section 3(h)(C). 

“Deferral Period” shall have the meaning set forth in Section 3(h). 

“Demand Notice” shall have the meaning set forth in Section 2(a)(i). 

“Disclosure Package” means, with respect to any offering of securities, (i) the preliminary prospectus,
(ii) each Free Writing Prospectus and (iii) all other information, in each case, that is deemed, under Rule 159 promulgated under the Securities Act, to have been conveyed to purchasers of securities at the time of sale of such securities
(including, without limitation, a contract of sale). 
 “Effectiveness Deadline” shall mean the date that is
120 days after the date of this Agreement (or the date that is 150 days after the date of this Agreement, if the Shelf Registration Statement is reviewed by the Commission). 

“Exchange Act” means the Securities Exchange Act of 1934, as amended, and the rules and regulations
promulgated thereunder. 
 “Exchange Act Report” shall have the meaning set forth
in Section 3(h). 
 “Excluded Registration” means (i) a registration relating to the
sale of securities to employees of the Company or a subsidiary pursuant to a stock option, stock purchase, or similar plan or (ii) a registration relating to an SEC Rule 145 transaction. 

“Existing Stockholder” shall have the meaning set forth in the recitals hereto. 

 “Existing Stockholder Restricted Shares” shall have the meaning
set forth in Section 4(b)(i). 
 “Filing Deadline” shall mean the date that is 60 days after the
date of this Agreement. 
 “Free Writing Prospectus” means any “free writing prospectus” as
defined in Rule 405 promulgated under the Securities Act. 
 “Holder” means a holder of record of
Registrable Shares. 
 “Holder Indemnified Party” shall have the meaning set forth
in Section 6(a). 
 “Indemnified Party” shall have the meaning set forth
in Section 6(c). 
 “Initiating Holders” shall have the meaning set forth
in Section 2(a)(i). 
 “Institutional Investors” shall mean the Investors listed on
Schedule IV attached to the Purchase Agreement. 
 “Investor” shall have the meaning set forth in the
recitals hereto. 
 “Investor Restricted Shares” shall have the meaning set forth in
Section 4(c). 
 “Lead Investor” shall mean EcoR1. 

“Lead Investor Counsel” shall have the meaning set forth in Section 3(j). 

“Lock-Up Period” shall have the meaning set forth in Section 4(b)(i). 

“Material Event” shall have the meaning set forth in Section 3(h). 

“Merger” means that transaction contemplated by the Agreement and Plan of Merger with Zeta, and Kura
Operations, Inc., a Delaware corporation and wholly-owned subsidiary of Zeta (“Merger Sub”), pursuant to which Merger Sub with merge with and into the Company, with the Company remaining as the surviving corporation. 

“National Exchange” shall have the meaning set forth in Section 4(b). 

“Notice and Questionnaire” shall have the meaning set forth in Section 3(a). 

“Outstanding Capital Stock” means each share of capital stock of the Company outstanding immediately prior to
the Closing. 
 “Permissible Deferral Period” shall have the meaning set forth
in Section 1(d). 
 “Person” means any individual, partnership, joint-stock company,
corporation, limited liability company, trust or unincorporated organization, and a government or agency or political subdivision thereof. 

“Purchase Agreement” shall have the meaning set forth in the recitals hereto. 

“Registrable Shares” means (A) each share of Common Stock acquired by the Investors pursuant to the
Purchase Agreement, (B) each share of Outstanding Capital Stock held by the Existing Stockholders, and (C) any stock of the Company or Zeta issued as a dividend or other distribution with respect to or in exchange for, the capital stock
referred to in clauses (A) and (B) above (including, but not limited to, shares Zeta Stock issued in exchange of such shares in the Merger); until the date on which all of the Registrable Shares then owned by such Holder have been
effectively registered under the Securities Act and disposed of in accordance with such registration statement. 

“Rule 10b5-1 Plan” shall have the meaning set forth in Section 4(b)(ii). 

 “Rule 415 Limitation” shall have the meaning set forth
in Section 1(a). 
 “Securities Act” means the Securities Act of 1933, as amended, and the
rules and regulations promulgated thereunder. 
 “Shelf Registration” shall have the meaning set forth
in Section 1(a). 
 “Shelf Registration Period” shall have the meaning set forth
in Section 1(b). 
 “Shelf Registration Statement” shall have the meaning set forth
in Section 1(a). 
 “Stockholder” shall have the meaning set forth in the recitals hereto.

 “Subsequent Shelf Limitation” shall have the meaning set forth in Section 1(a). 

“Updated Disclosure Package” shall have the meaning set forth in Section 6(a). 

“Zeta” shall have the meaning set forth in the recitals hereto. 

“Zeta Assignment” shall have the meaning set forth in Section 8(f). 

“Zeta Stock” shall have the meaning set forth in Section 8(f). 

[The remainder of this page is intentionally left blank.] 

 IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the date first
above written. 
  

			
	 THE CORPORATION:
  

KURA ONCOLOGY, INC.

		
	By:		 /s/ Troy Wilson

	Name:		Troy Wilson, Ph.D.
	Title:		Chief Executive Officer

 
			
	As the successor and assign to the Corporation pursuant to Section 8 hereof:
	
	ZETA ACQUISITION CORP. III
		
	By:		 /s/ John Pappajohn

	Name: John Pappajohn
	Title: President and Director and Principal Executive Officer

  

			
			INVESTORS:
		
			[Signature Pages Attached]

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