Document:

Exhibit 10.18

 

 

 

 

RIVERSIDE CENTER

TWO RIVERSIDE CENTER

NEWTON, MASSACHUSETTS

 

 

OFFICE LEASE AGREEMENT

 

BETWEEN

 

 

HINES GLOBAL REIT RIVERSIDE CENTER, LLC,

a Delaware limited liability company

(“LANDLORD”)

 

 

AND

 

 

CLEMENTIA PHARMACEUTICALS USA, INC.,

a Delaware corporation

(“TENANT”)

 

 

 

 

 

 

     

     

    

 

OFFICE LEASE AGREEMENT

 

THIS OFFICE LEASE AGREEMENT (this “Lease”)
is made and entered into as of February 13, 2019, by and between HINES GLOBAL REIT .RIVERSIDE CENTER, LLC, a Delaware limited
liability company (“Landlord”), and CLEMENTIA PHARMACEUTICALS USA, INC., a Delaware corporation (“Tenant”).
The following exhibits and attachments are incorporated into and made a part of this Lease: Exhibit A (Outline and
Location of Premises), Exhibit B (Expenses and Taxes), Exhibit C (Work Letter), Exhibit D (Commencement
Letter), Exhibit E (Building Rules and Regulations), Exhibit F (Additional Provisions), and Exhibit G
(Guaranty).

 

1.             
Basic Lease Information.

 

1.01       
“Building” shall mean the building located at 275 Grove Street, Newton, Massachusetts 02466, and commonly
known as Riverside Center. Landlord and Tenant acknowledge that the “Building”, as defined herein, consists of three
buildings commonly known as One Riverside Center, Two Riverside Center and Three Riverside Center. “Rentable Square Footage
of the Building” is deemed to be 504,945 square feet.

 

1.02       
“Premises” shall mean the area shown on Exhibit A to this Lease. The Premises is located
on the first (1st) floor of Two Riverside Center and known as Suite 2- 130. The “Rentable Square Footage of the Premises”
is deemed to be 9,074 square feet. Landlord and Tenant stipulate and agree that the Rentable Square Footage of the Building and
die Rentable Square Footage of the Premises are correct.

 

1.03       
“Base Rent”:

 

	Rent Year*	Monthly Base Rent	Annual Base 

Rent per RSF
	Commencement Date - Rent Commencement Date	$-0-	$-0-
	Rent Year 1	$35,917.92	$47.50
	Rent Year 2	$36,674.08	$48.50
	Rent Year 3	$37,430.25	$49.50
	Rent Year 4	$38,186.42	$50.50
	Rent Year 5	$38,942.58	$51.50

 

 

*“Rent Year” shall be defined as a twelve-(12)-month
period beginning on the Rent Commencement Date or an anniversary of the Rent Commencement Date, except that if the Rent Commencement
Date does not fall on the first day of a calendar month, then the first Rent Year shall begin on the Rent Commencement Date and
end on the last day of the month containing the first anniversary of the Rent Commencement Date, and each succeeding Rent Year
shall begin on the day following the last clay of the prior Rent Year, and the Monthly Base Rent for the first month of such Rent
Year shall be appropriately prorated.

 

     

     

    

 

1.04       
“Tenant’s Pro Rata Share”: 1.80%.

 

1.05       
“Base Year” for Taxes (defined in Exhibit B): Fiscal Year (defined below) 2020 (i.e., July
1, 2019, to June 30, 2020); “Base Year” for Expenses (defined in Exhibit B): calendar year 2019.

 

For purposes hereof, “Fiscal Year” shall
mean the Base Year for Taxes and each period of July 1 to June 30 thereafter.

 

1.06       
“Term”: The period commencing on the Commencement Date (defined below) and, unless extended or terminated
earlier in accordance with this Lease, ending on the last day of the sixty-first (61st) full calendar month following the Commencement
Date (the “Termination Date”). The “Commencement Date” shall mean the date on which the Landlord
Work (defined in Section 1.14) is Substantially Complete (defined in Exhibit C). The parties anticipate that the Landlord
Work will be Substantially Complete oh or about May 1, 2019 (the “Target Commencement Date”). The “Rent
Commencement Date” shall be the date that is one (1) month following the Commencement Date. Tenant shall have the option
to extend the Term for one (1) additional period of five (5) years, as more particularly set forth in Section 2 of Exhibit F
attached hereto.

 

1.07       
“Allowance”: An amount not to exceed $362,960.00, as further described in the attached Exhibit C.

 

1.08       
“Security Deposit”: $215,507.50 (i.e., six (6) Monthly Base Rent payments), as more fully described in
Section 6.

 

1.09       
“Guarantor(s)”: Clementia Pharmaceuticals, Inc., a Quebec corporation.

 

1.10       
“Brokers”: Jones Lang LaSalle (“Tenant’s Broker”), which represented Tenant
in connection with this transaction, and Cushman & Wakefield (“Landlord’s Broker”), which represented
Landlord in connection with this transaction.

 

1.11       
“Permitted Use”: General Business Office.

 

1.12       
“Notice Address(es)”:

 

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	Landlord:	Tenant:
	 	 
	
        Hines Global REIT Riverside Center, LLC

        c/o Hines Global REIT Inc.

        2800 Post Oak Boulevard,

        Suite 4800

        Houston, Texas 77056

        Attention: Sherri Shugart
	
        Prior to the Commencement Date:

         

        Clementia Pharmaceuticals USA, Inc.

        275 Grove Street, Suite 2-400

        Newton, MA 02466

        Attention: Jeff Packman

	 	 
	With copies of any notices to Landlord shall be sent to:	With copies of any notices to Tenant to be 

sent via email to 

accounting@clementiapharma.com
	 	 
	
        Hines Interests Limited Partnership

        275 Grove Street

        Newton, MA 02466

        Attention: Property Manager

         

        And

         

        Goulston & Storrs, P.C.

        400 Atlantic Avenue

        Boston, Massachusetts 02110

        Attention: Riverside Center/Newton, Massachusetts

        
	
        From and after the Commencement Date:

         

        Clementia Pharmaceuticals USA, Inc.

        275 Grove Street, Suite 2-130

        Newton, MA 02466

        Attention: Jeff Packman

         

        With copies of any notices to Tenant to be 

sent via email to 

accounting@clementiapharma.com

 

1.13       
 “Business Day(s)” are Monday through Friday of each week, exclusive of New Year’s Day, Presidents’
Day, Memorial Day, Independence Day, Labor Day, Thanksgiving Day and Christmas Day (“Holidays”). Landlord may
designate additional Holidays that are commonly recognized by other office buildings in the area where the Building is located.
“Building Service Hours” are 8:00 A.M. to 6:00 P.M. on Business Days and 8:00 A.M. to 1:00 P.M. on Saturdays.

 

1.14       
“Landlord Work” means the work that Landlord is obligated to perform in the Premises pursuant to a separate
agreement (the “Work Letter”) attached to this Lease as Exhibit C.

 

1.15       
“Property” means the Building and the parcel(s) of land on which it is located and, at Landlord’s
discretion, the parking facilities and other improvements, if any, serving the Building and the parcel(s) of land on which they
are located.

 

1.16       
Tenant shall not record this Lease or any memorandum or notice hereof without Landlord’s prior written consent. If
this Lease is terminated before the Term expires, upon Landlord’s request, the parties shall execute, deliver and record
an instrument acknowledging the above and the date of the termination of this Lease, and Tenant appoints Landlord its attorney-in-fact
in its name and behalf to execute the instrument if Tenant shall fail to execute and deliver the instrument after Landlord’s
request therefor within ten (10) days.

 

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2.             
Lease Grant.

 

Landlord hereby leases the Premises to Tenant and Tenant hereby
leases the Premises from Landlord. Tenant has the non-exclusive right, at no additional charge to Tenant, to use any portions of
the Property that are designated by Landlord for the common use of tenants and others (the “Common Areas”).

 

3.             
Adjustment of Commencement Date; Possession.

 

3.01       
Subject to Landlord’s obligation to perform the Landlord Work, as hereinafter defined, and provide the Allowance,
the Premises are accepted by Tenant in “as is” condition and configuration without any representations or warranties
by Landlord. By taking possession of the Premises, Tenant agrees that the Premises are in good order and satisfactory condition.
Landlord shall not be liable for a failure to deliver possession of the Premises or any other space due to the holdover or unlawful
possession of such space by another party, provided, however. Landlord shall use reasonable efforts to obtain possession of any
such space. In such event, the Commencement Date for the Premises, or the commencement date for such other space, as applicable,
shall be postponed until the date Landlord delivers possession of such space to Tenant free from occupancy by any party. Landlord’s
failure to Substantially Complete (as hereinafter defined) the Landlord Work by the Target Commencement Date (described in Section
1.06) shall not be a default by Landlord or otherwise render Landlord liable for damages. Except as otherwise provided in this
Lease, Tenant shall not be permitted to take possession of or enter the Premises prior to the Commencement Date without Landlord’s
permission. If Tenant takes possession of or enters the Premises before the Commencement Date, Tenant shall be subject to the terms
and conditions of this Lease; provided, however, except for the cost of services requested by Tenant (e.g., after hours HVAC service),
Tenant shall not be required to pay Rent for any entry or possession before the Commencement Date during which Tenant, with Landlord’s
approval, has entered, or is in possession of, the Premises for the sole purpose of performing improvements or installing furniture,
equipment or other personal property.

 

3.02       
Promptly after the determination of the Commencement Date, Landlord and Tenant shall execute and deliver a commencement
letter in the form attached as Exhibit D (the “Commencement Letter”). Tenant’s failure to
execute and return the Commencement Letter, or to provide written objection to the statements contained in the Commencement Letter,
within fifteen (15) days after the date of the Commencement Letter shall be deemed an approval by Tenant of the statements contained
therein.

 

4.             
Rent.

 

4.01       
Tenant shall pay Landlord, without any setoff or deduction, unless expressly set forth in this Lease, all Base Rent and
Additional Rent due for the Term (collectively referred to as “Rent”). “Additional Rent”
means all sums (exclusive of Base Rent) that Tenant is required to pay Landlord under this Lease. Tenant shall pay and be liable
for all rental, sales and use taxes (but excluding income taxes), if any, imposed upon or measured by Rent. Base Rent and recurring
monthly charges of Additional Rent shall be due and payable in advance on the first day of each calendar month without notice or
demand, provided that the installment of Base Rent for the first full calendar month of the Term, and the first monthly installment
of Additional Rent for Expenses and Taxes, shall be payable upon the execution of this Lease by Tenant. All other items of Rent
shall be due and payable by Tenant on or before thirty (30) days after billing by Landlord. Rent shall be made payable to the entity,
and sent to the address. Landlord designates and shall be made by good and sufficient check payable in United States of America
currency or by other means acceptable to Landlord. If Tenant does not pay any Rent when due hereunder. Tenant shall pay Landlord
an administration fee in the amount of $250.00, provided that Tenant shall be entitled to a grace period of up to five (5) days
for the first late payment of Rent in a calendar year. In addition, past due Rent shall accrue interest at twelve percent (12%)
per annum, and Tenant shall pay Landlord a reasonable fee for any checks returned by Tenant’s bank for any reason. Landlord’s
acceptance of less than the correct amount of Rent shall be considered a payment on account of the oldest obligation due from Tenant
hereunder, then to any current Rent then due hereunder, notwithstanding any statement to the contrary contained on or accompanying
any such payment from Tenant. Rent for any partial month during the Term shall be prorated. No endorsement or statement on a check
or letter accompanying payment shall be considered an accord and satisfaction. Tenant’s covenant to pay Rent is independent
of every other covenant in this Lease.

 

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4.02       
Tenant shall pay Tenant’s Pro Rata Share of Taxes and Expenses in accordance with Exhibit B of this Lease.

 

5.             
Compliance with Laws; Use.

 

The Premises shall be used for the Permitted
Use and for no other use whatsoever. Tenant shall comply with all statutes, codes, ordinances, orders, rules and regulations of
any municipal or governmental entity whether in effect now or later, including the Americans with Disabilities Act (“Law(s)”),
regarding the operation of Tenant’s business, the use, condition, configuration and occupancy of the Premises and the Building
systems located in or exclusively serving the Premises. In addition, Tenant shall, at its sole cost and expense, promptly comply
with any Laws that relate to the “Base Building” (defined below), but only to the extent such obligations are triggered
by Tenant’s use of the Premises, other than for general office use, or Alterations or improvements in the Premises performed
or requested by Tenant. “Base Building” shall include the structural portions of the Building, the public restrooms
and the Building mechanical, electrical and plumbing systems and equipment located in the internal core of the Building on the
floor or floors on which the Premises are located. Tenant shall promptly provide Landlord with copies of any notices it receives
regarding an alleged violation of Law. Tenant shall not exceed the standard density limit for the Building. Tenant shall comply
with the rules and regulations of the Building attached as Exhibit E and such other reasonable rules and regulations
adopted by Landlord from time to time, including rules and regulations for the performance of Alterations (defined in Section 9.03).

 

6.             
Security Deposit.

 

The Security Deposit shall be delivered to Landlord
upon the execution of this Lease by Tenant and held by Landlord without liability for interest (unless required by Law) as security
for the performance of Tenant’s obligations. The Security Deposit is not an advance payment of Rent or a measure of damages.
Landlord may from time to time and without prejudice to any other remedy provided in this Lease or by Law, use all or a portion
of the Security Deposit to the extent necessary to satisfy past due Rent or to satisfy any other loss or damage resulting from
Tenant’s breach under this Lease. If Landlord uses any portion of the Security Deposit, Tenant, within five (5) business
days after demand, shall restore the Security Deposit to its original amount. Landlord shall return any unapplied portion of the
Security Deposit to Tenant within thirty (30) days after the later to occur of: (a) determination of the final Rent due from Tenant;
or (b) the later to occur of the Termination Date or the date Tenant surrenders the Premises to Landlord in compliance with Section
25. Landlord may assign the Security Deposit to a successor or transferee and, following the assignment. Landlord shall have no
further liability for the return of the Security Deposit. Landlord shall not be required to keep the Security Deposit separate
from its other accounts.

 

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7.             
Building Services.

 

7.01       
Landlord shall furnish Tenant with the following services: (a) water for use in the Base Building lavatories; (b) customary
heat and air conditioning in season during Building Service Hours, although (i) Tenant shall have the right to receive HVAC service
during hours other than Building Service Hours by paying Landlord’s then standard charge for additional HVAC service and
providing such prior notice as is reasonably specified by Landlord, and (ii) if Tenant is permitted to connect any supplemental
HVAC units to the Building’s condenser water loop or chilled water line, such permission shall be conditioned upon Landlord
having adequate excess capacity from time to time and such connection and use shall be subject to Landlord’s reasonable approval
and reasonable restrictions imposed by Landlord, and Landlord shall have the right to charge Tenant a connection fee and/or a monthly
usage fee, as reasonably determined by Landlord; (c) standard janitorial service on Business Days; (d) elevator service; (e) electricity
in accordance with the terms and conditions in Section 7.02; (f) access to the Building for Tenant and its employees twenty-four
(24) hours per day, seven (7) per week, subject to the terms of this Lease and such protective services or monitoring systems,
if any, as Landlord may reasonably impose, including, without limitation, sign-in procedures and/or presentation of identification
cards; and (g) such other services as Landlord reasonably determines are necessary or appropriate for the Property. If Landlord,
at Tenant’s request, provides any services which are not Landlord’s express obligation under this Lease, including,
without limitation, any repairs which are Tenant’s responsibility pursuant to Section 9 below, Tenant shall pay Landlord,
or such other party designated by Landlord, the cost of providing such service plus a reasonable administrative charge.

 

7.02       
Electricity used by Tenant in the Premises shall be paid for by Tenant by a separate monthly charge payable by Tenant to
Landlord as estimated by Landlord (and reconciled annually). Without the consent of Landlord, Tenant’s use of electrical
service shall not exceed the Building standard usage, per square foot, as reasonably determined by Landlord, based upon the Building
standard electrical design load. Landlord shall, at Landlord’s expense, install and measure electrical usage by commonly
accepted methods, including the installation of measuring devices such as submeters and check meters. If it is determined that
Tenant is using electricity in such quantities or during such periods as to cause the total cost of Tenant’s electrical usage,
on a monthly, per-rentable-square-foot basis, to materially exceed that which Landlord reasonably deems to be standard for the
Building, Tenant shall pay Landlord Additional Rent for the cost of such excess electrical usage and, if applicable, for the cost
of purchasing and installing the measuring device(s).

 

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7.03       
Landlord’s failure to furnish, or any interruption, diminishment or termination of services due to the application
of Laws, the failure of any equipment, the performance of maintenance, repairs, improvements or alterations, utility interruptions
or the occurrence of an event of Force Majeure (defined in Section 26.03) (collectively a “Service Failure”)
shall not render Landlord liable to Tenant, constitute a constructive eviction of Tenant, give rise to an abatement of Rent, nor
relieve Tenant from the obligation to fulfill any covenant or agreement. However, if the Premises, or a material portion of the
Premises, are made untenantable for a period in excess of three (3) consecutive Business Days as a result of a Service Failure
that is reasonably within the control of Landlord to correct, then Tenant, as its sole remedy, shall be entitled to receive an
abatement of Rent payable hereunder during the period beginning on the fourth (4th) consecutive Business Day of the Service Failure
and ending on the day the service has been restored. If the entire Premises have not been rendered untenantable by the Service
Failure, the amount of abatement shall be equitably prorated.

 

8.             
Leasehold Improvements.

 

All improvements in and to the Premises, including
any Alterations (defined in Section 9.03) (collectively, “Leasehold Improvements”) shall remain upon the Premises
at the end of the Term without compensation to Tenant, provided that Tenant, at its expense, shall remove any Cable (defined in
Section 9.01 below). In addition, Landlord, by written notice to Tenant at least sixty (60) days prior to the Termination Date,
may require Tenant, at Tenant’s expense, to remove any Landlord Work or Alterations that, in Landlord’s reasonable
judgment, are of a nature that would require removal and repair costs that are materially in excess of the removal and repair costs
associated with standard office improvements (the Cable and such other items collectively are referred to as “Required
Removables”). Required Removables shall include, without limitation, internal stairways, raised floors, personal baths
and showers, vaults, rolling file systems and structural alterations and modifications. The Required Removables shall be removed
by Tenant before the Termination Date. Tenant shall repair damage caused by the installation or removal of Required Removables.
If Tenant fails to perform its obligations in a timely manner, Landlord may perform such work at Tenant’s expense. Tenant,
at the time it requests approval for a proposed Alteration, including any Initial Alterations or Landlord Work, as such terms may
be defined in the Work Letter attached as Exhibit C, may request in writing that Landlord advise Tenant whether the
Alteration, including any Initial Alterations or Landlord Work, or any portion thereof, is a Required Removable. Within seven (7)
days after receipt of Tenant’s request, Landlord shall advise Tenant in writing as to which portions of the alteration or
other improvements are Required Removables.

 

9.             
Repairs and Alterations.

 

9.01       
Tenant shall periodically inspect the Premises to identify any conditions that are dangerous or in need of maintenance or
repair. Tenant shall promptly provide Landlord with notice of any such conditions. Tenant, at its sole cost and expense, shall
perform all maintenance and repairs to the Premises that are not Landlord’s express responsibility under this Lease, and
keep the Premises in good condition and repair, reasonable wear and tear excepted. Tenant’s repair and maintenance obligations
include, without limitation, repairs to: (a) floor covering; interior partitions; (c) doors; (d) the interior side of demising
walls; (e) Alterations (described in Section 9.03); (1) supplemental air conditioning units, kitchens, including hot water heaters,
plumbing, and similar facilities exclusively serving Tenant, whether such items are installed by Tenant or are currently existing
in the Premises; and (g) electronic, fiber, phone and data cabling and related equipment that is installed by or for the exclusive
benefit of Tenant (collectively, “Cable”). AM repairs and other work performed by Tenant or its contractors,
including that involving Cable, shall be subject to the terms of Section 9.03 below. If Tenant fails to make any repairs to the
Premises for more than fifteen (15) days after notice from Landlord (although notice shall not be required in an emergency), Landlord
may make the repairs, and, within thirty (30) days after demand, Tenant shall pay the reasonable cost of the repairs, together
with an administrative charge in an amount equal to ten percent (10%) of the cost of the repairs.

 

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9.02       
Landlord shall keep and maintain in good repair and working order and perform maintenance upon the: (a) structural elements
of the Building; (b) mechanical (including HVAC), electrical, plumbing and tire/life safety systems serving the Building in general;
(c) Common Areas; (d) roof of the Building; (e) exterior windows of the Building; and (f) elevators serving the Building.
Landlord shall promptly make repairs for which Landlord is responsible.

 

9.03       
Tenant shall not make alterations, repairs, additions or improvements or install any Cable (collectively referred to as
“Alterations”) without first obtaining the written consent of Landlord in each instance, which consent shall
not be unreasonably withheld or delayed. However, Landlord’s consent shall not. be required for any Alteration that satisfies
all of the following criteria (a “Cosmetic Alteration”): (a) is of a cosmetic nature such as painting, wallpapering,
hanging pictures and installing carpeting; (b) is not visible from the exterior of the Premises or Building; (c) will not affect
the Base Building (defined in Section 5); and (d) does not require work to be performed inside the walls or above the ceiling of
the Premises. Cosmetic Alterations shall be subject to all the other provisions of this Section 9.03. Prior to starting work, Tenant
shall furnish Landlord with plans and specifications (which shall be in CAD format if requested by Landlord); names of contractors
reasonably acceptable to Landlord (provided that Landlord may designate specific contractors with respect to Base Building and
vertical Cable, as may be described more fully below); required permits and approvals; evidence of contractor’s and subcontractor’s
insurance in amounts reasonably required by Landlord and naming Landlord and the managing agent for the Building (or any successor(s))
as additional insureds; and any security for performance in amounts reasonably required by Landlord. Landlord may designate specific
contractors with respect to oversight, installation, repair, connection to, and removal of vertical Cable. All Cable shall be clearly
marked with adhesive plastic labels (or plastic tags attached to such Cable with wire) to show Tenant’s name, suite number,
and the purpose of such Cable (i) every 6 feet outside the Premises (specifically including, but not limited to, the electrical
room risers and any Common Areas), and (ii) at the termination point(s) of such Cable. Changes to the plans and specifications
must also be submitted to Landlord for its approval. Alterations shall be constructed in a good and workmanlike manner using materials
of a quality reasonably approved by Landlord, and Tenant shall ensure that no Alteration impairs any Building system or Landlord’s
ability to perform its obligations hereunder. Tenant shall reimburse Landlord for any sums paid by Landlord for third party examination
of Tenant’s plans for non-Cosmetic Alterations. In addition, Tenant shall pay Landlord a fee for Landlord’s oversight
and coordination of any non-Cosmetic Alterations equal to five percent (5%) of the cost of the non-Cosmetic Alterations. Upon completion,
Tenant shall furnish “as-built” plans (in CAD format, if requested by Landlord) for non-Cosmetic Alterations, completion
affidavits and full and final waivers of lien. Landlord’s approval of an Alteration shall not be deemed a representation
by Landlord that the Alteration complies with Law.

 

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10.          
Entry by Landlord.

 

Landlord may enter the Premises to inspect,
show or clean the Premises or to perform or facilitate the performance of repairs, alterations or additions to the Premises or
any portion of the Building. Except in emergencies or to provide Building services. Landlord shall provide Tenant with reasonable
prior verbal notice of entry and shall use reasonable efforts to minimize any interference with Tenant’s use of the Premises.
If reasonably necessary, Landlord may temporarily close all or a portion of the Premises to perform repairs, alterations and additions.
However, except in emergencies, Landlord will not close the Premises if the work can reasonably be completed on weekends and after
Building Service Hours. Entry by Landlord shall not constitute a constructive eviction or entitle Tenant to an abatement or reduction
of Rent.

 

11.          
Assignment and Subletting.

 

11.01    
Except in connection with a Business Transfer (defined in Section 11.04), Tenant shall not assign, sublease, transfer or
encumber any interest in this Lease or allow any third party to use any portion of the Premises (collectively or individually,
a “Transfer”) without the prior written consent of Landlord, which consent shall not be unreasonably withheld,
conditioned or delayed if Landlord does not exercise its recapture rights under Section 11.02. Without limitation, it is agreed
that Landlord’s consent shall not be considered unreasonably withheld if the proposed transferee is a governmental entity
or an occupant of the Building or an occupant of any other buildings within the same project or if the proposed transferee, whether
or not an occupant of the Building or an occupant of any other buildings within the same project, is in discussions with Landlord
regarding the leasing of space within the Building or within any other buildings within the same project. If the entity(ies) which
directly or indirectly controls the voting shares/rights of Tenant (other than through the ownership of voting securities listed
on a recognized securities exchange) changes at any time, such change of ownership or control shall constitute a Transfer. Any
Transfer in violation of this Section shall, at Landlord’s option, be deemed a Default by Tenant as described in Section
18, and shall be voidable by Landlord. In no event shall any Transfer, including a Business Transfer (as defined in Section 11.04),
release or relieve Tenant from any obligation under this Lease, and Tenant shall remain primarily liable for the performance of
the tenant’s obligations under this Lease, as amended from time to time.

 

11.02    
Tenant shall provide Landlord with financial statements for the proposed transferee (or, in the case of a change of ownership
or control, for the proposed new controlling entity(ies)), a fully executed copy of the proposed assignment, sublease or other
Transfer documentation and such other information as Landlord may reasonably request. Within fifteen (15) Business Days after receipt
of the required information and documentation, Landlord shall either: (a) consent to the Transfer by execution of a consent agreement
in a form reasonably designated by Landlord; (b) reasonably refuse to consent to the Transfer in writing; or (c) in the event of
an assignment of this Lease or subletting of more than twenty percent (20%) of the Rentable Square Footage of the Premises for
more than fifty percent (50%) of the remaining Term (excluding unexercised options), recapture the portion of the Premises that
Tenant is proposing to Transfer. If Landlord exercises its right to recapture, this Lease shall automatically be amended (or terminated
if the entire Premises is being assigned or sublet) to delete the applicable portion of the Premises effective on the proposed
effective date of the Transfer, although Landlord may require Tenant to execute a reasonable amendment or other document reflecting
such reduction or termination. Tenant shall pay Landlord a review fee of $1,500.00 for Landlord’s review of any requested
Transfer.

 

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11.03    
Tenant shall pay Landlord fifty percent (50%) of all rent and other consideration which Tenant receives as a result of a
Transfer that is in excess of the Rent payable to Landlord for the portion of the Premises and Term covered by the Transfer. Tenant
shall pay Landlord for Landlord’s share of the excess within thirty (30) days after Tenant’s receipt of the excess.
In determining the excess due Landlord, Tenant may deduct from the excess, on a straight-line basis, all reasonable and customary
expenses directly incurred by Tenant attributable to the Transfer. If Tenant is in Default, Landlord may require that all sublease
payments be made directly to Landlord, in which case Tenant shall receive a credit against Rent in the amount of Tenant’s
share of payments received by Landlord.

 

11.04    
Tenant may assign this Lease to a successor to Tenant by merger, consolidation or the purchase of substantially all of Tenant’s
assets, or assign this Lease or sublet all or a portion of the Premises to an Affiliate (defined below), without the consent of
Landlord, provided that all of the following conditions are satisfied (a “Business Transfer”): (a) Tenant must
not be in Default; (b) Tenant must give Landlord written notice at least fifteen (15) Business Days before such Transfer; and (c)
except in the case of an assignment or sublease to an Affiliate, the Credit Requirement (defined below) must be satisfied. Tenant’s
notice to Landlord shall include information and documentation evidencing the Business Transfer and showing that each of the above
conditions has been satisfied. If requested by Landlord, Tenant’s successor shall sign and deliver to Landlord a commercially
reasonable form of assumption agreement. “Affiliate” shall mean an entity controlled by, controlling or under
common control with Tenant. The “Credit Requirement” shall be deemed satisfied if, as of the date immediately
preceding the date of the Business Transfer, the financial strength of (i) the entity with which Tenant is to merge or consolidate
or (ii) the purchaser of substantially all of the assets of Tenant is not less than that of Tenant, as determined (x) based on
credit ratings of such entity and Tenant by both Moody’s and Standard & Poor’s (or by either such agency alone,
if applicable ratings by the other agency do not exist), or (y) if such credit ratings do not exist, then in accordance with Moody’s
KMV RiskCalc (i.e., the on-line software tool offered by Moody’s for analyzing credit risk) based on CFO-certified financial
statements for such entity and Tenant covering their last two (2) fiscal years ending before the Transfer.

 

11.05    
Notwithstanding anything to the contrary contained in this Section 11, neither Tenant nor any other person having a right
to possess, use, or occupy (for convenience, collectively referred to in this subsection as “Use”) the Premises
shall enter into any lease, sublease, license, concession or other agreement for Use of all or any portion of the Premises which
provides for rental or other payment for such Use based, in whole or in part, on the net income or profits derived by any person
that leases, possesses, uses, or occupies all or any portion of the Premises (other than an amount based on a fixed percentage
or percentages of receipts or sales), and any such purported lease, sublease, license, concession or other agreement shall be absolutely
void and ineffective as a transfer of any right or interest in the Use of all or any part of the Premises.

 

    	10

     

    

 

12.          
Liens.

 

Tenant shall not permit mechanics’ or
other liens to be placed upon the Property, Premises or Tenant’s leasehold interest in connection with any work or service
done or purportedly done by or for the benefit of Tenant or its subtenants or transferees. Tenant shall give Landlord notice at
least fifteen (15) days prior to the commencement of any work in the Premises to afford Landlord the opportunity, where applicable,
to post and record notices of non-responsibility. Tenant, within ten (10) days of notice from Landlord, shall fully discharge any
lien by settlement, by bonding or by insuring over the lien in the manner prescribed by the applicable lien Law and, if Tenant
fails to do so, Tenant shall be deemed in Default under this Lease and, in addition to any other remedies available to Landlord
as a result of such Default by Tenant, Landlord, at its option, may bond, insure over or otherwise discharge the lien. Tenant shall
reimburse Landlord for any amount paid by Landlord, including, without limitation, reasonable attorneys’ fees. Landlord shall
have the right to require Tenant to post a performance or payment bond in connection with any work or service done or purportedly
done by or for the benefit of Tenant. Tenant acknowledges and agrees that all such work or service is being performed for the sole
benefit of Tenant and not for the benefit of Landlord.

 

13.          
Indemnity and Waiver of Claims.

 

Except to the extent caused by the negligence
or willful misconduct of Landlord or any Landlord Related Parties (defined below), Tenant shall indemnify, defend and hold Landlord
and Landlord Related Parties harmless against and from all liabilities, obligations, damages, penalties, claims, actions, costs,
charges and expenses, including, without limitation, reasonable attorneys’ fees and other professional fees (if and to the
extent permitted by Law) (collectively referred to as “Losses”), which may be imposed upon, incurred by or asserted
against Landlord or any of the Landlord Related Parties by any third party and arising out of or in connection with any damage
or injury occurring in the Premises or any acts or omissions (including violations of Law) of Tenant, its trustees, managers, members,
principals, beneficiaries, partners, officers, directors, employees and agents (the “Tenant Related Parties”)
or any of Tenant’s transferees, contractors or licensees. Tenant hereby waives all claims against and releases Landlord and
its trustees, managers, members, principals, beneficiaries, partners, officers, directors, employees, Mortgagees (defined in Section
23) and agents (the “Landlord Related Parties”) from all claims for any injury to or death of persons, damage
to property or business loss in any manner related to (a) Force Majeure, (b) acts of third parties, (c) the bursting or leaking
of any tank, water closet, drain or other pipe, (d) the inadequacy or failure of any security or protective services, personnel
or equipment, or (e) any matter not within the reasonable control of Landlord.

 

14.          
Tenant’s Insurance. Tenant shall maintain the following coverages in the following amounts:

 

14.01    
Commercial General Liability Insurance covering claims of bodily injury, personal injury and property damage arising out
of Tenant’s operations and contractual liabilities, including coverage formerly known as broad form, on an occurrence basis,
with minimum primary limits of $2,000,000 each occurrence and $4,000,000 annual aggregate and a minimum excess/umbrella limit of
$3,000,000.

 

    	11

     

    

 

14.02    
Property insurance covering (i)all office furniture, business and trade fixtures, office equipment, free-standing cabinet
work, movable partitions, merchandise and all other items of Tenant’s property in the Premises installed by, for, or at the
expense of Tenant (“Tenant’s Property”), and (ii) any Leasehold Improvements installed by or for the benefit
of Tenant, whether pursuant to this Lease or pursuant to any prior lease or other agreement to which Tenant was a party (“Tenant-Insured
Improvements”). Such insurance shall be written on a special cause of loss form for physical loss or damage, for the
full replacement cost value (subject to reasonable deductible amounts) without deduction for depreciation of the covered items
and in amounts that meet any co-insurance clauses of the policies of insurance, and shall include coverage for damage or other
loss caused by fire or other peril, including vandalism and malicious mischief, theft, water damage of any type, including sprinkler
leakage, bursting or stoppage of pipes, and explosion, and providing business interruption coverage for a period of one year.

 

14.03    
Worker’s Compensation and Employer’s Liability or other similar insurance to the extent required by Law.

 

14.04    
Form of Policies. The minimum limits of insurance required to be carried by Tenant shall not limit Tenant’s
liability. Such insurance shall (i) be issued by an insurance company that has an A.M. Best rating of not less than A-VIII; (ii)
be in form and content reasonably acceptable to Landlord; and (iii) provide that it shall not be canceled or materially changed
without thirty (30) days’ prior notice to Landlord, except that ten (10) days’ prior notice may be given in the case
of nonpayment of premiums. Tenant’s Commercial General Liability Insurance shall (a) name Landlord, Landlord’s managing
agent, and any other party designated by Landlord (“Additional Insured Parties”) as additional insureds; and
(b) be primary insurance as to all claims thereunder and provide that any insurance carried by Landlord is excess and non-contributing
with Tenant’s insurance. Landlord shall be designated as a loss payee with respect to Tenant’s Property insurance on
any Tenant-Insured Improvements. Tenant shall deliver to Landlord, on or before the Commencement Date and at least fifteen (15)
days before the expiration dates thereof, certificates from Tenant’s insurance company on the forms currently designated
“ACORD 28” (Evidence of Commercial Property Insurance) and “ACORD 25-S” (Certificate of Liability Insurance)
or the equivalent. Attached to the ACORD 25-S (or equivalent) there shall be an endorsement naming the Additional Insured Parties
as additional insureds which shall be binding on Tenant’s insurance company and shall expressly require the insurance company
to notify each Additional Insured Party in writing at least thirty (30) days before any termination or material change to the policies,
except that ten (10) days’ prior notice may be given in the case of nonpayment of premiums. Upon Landlord’s request,
Tenant shall deliver to Landlord, in lieu of such certificates, copies of the policies of insurance required to be carried under
Section 14.01 showing that the Additional Insured Parties are named as additional insureds.

 

14.05    
Tenant shall maintain such increased amounts of the insurance required to be carried by Tenant under this Section 14, and
such other types and amounts of insurance covering the Premises and Tenant’s operations therein, as may be reasonably requested
by Landlord, but not in excess of the amounts and types of insurance then being required by landlords of buildings comparable to
and in the vicinity of the Building.

 

14.06    
Landlord makes no representation or warranty to Tenant that the amount of insurance required to be carried by Tenant under
the terms of this Lease is adequate to fully protect Tenant’s interests. Tenant is encouraged to evaluate its insurance needs
and obtain whatever additional types or amounts of insurance that it may deem desirable or appropriate.

 

    	12

     

    

 

15.          
Subrogation.

 

Notwithstanding anything to the contrary set
forth in this Lease, each party waives, and shall cause its insurance carrier to waive, any right of recovery against the other
for any loss of or damage to property which loss or damage is (or, if the insurance required hereunder had been carried, would
have been) covered by insurance. For purposes of this Section 15, any deductible with respect to a party’s insurance shall
be deemed covered by, and recoverable by such party under, valid and collectable policies of insurance.

 

16.          
Casualty Damage.

 

16.01    
If all or any portion of the Premises becomes untenantable or inaccessible by fire or other casualty to the Premises or
the Common Areas (collectively a “Casualty”), Landlord, with reasonable promptness, shall cause a general contractor
selected by Landlord to provide Landlord with a written estimate of the amount of time required, using standard working methods,
to substantially complete the repair and restoration of the Premises and any Common Areas necessary to provide access to the Premises
(“Completion Estimate”). Landlord shall promptly forward a copy of the Completion Estimate to Tenant. If the
Completion Estimate indicates that the Premises or any Common Areas necessary to provide access to the Premises cannot be made
tenantable within two hundred seventy (270) days from the date the repair is started, then either party shall have the right to
terminate this Lease upon written notice to the other within ten (10) days after Tenant’s receipt of the Completion Estimate.
Tenant, however, shall not have the right to terminate this Lease if the Casualty was caused by the negligence or intentional misconduct
of Tenant or any Tenant Related Parties. In addition, Landlord, by notice to Tenant within ninety (90) days after the date of the
Casualty, shall have the right to terminate this Lease if: (1) the Premises have been materially damaged and there is less than
two (2) years of the Term remaining on the date of the Casualty; (2) any Mortgagee requires that the insurance proceeds be applied
to the payment of the mortgage debt; or (3) a material uninsured loss to the Building or Premises occurs.

 

16.02    
If this Lease is not terminated, Landlord shall promptly and diligently, subject to reasonable delays for insurance adjustment
or other matters beyond Landlord’s reasonable control, restore the Premises and Common Areas. Such restoration shall be to
substantially the same condition that existed prior to the Casualty, except for modifications required by Law or any other modifications
to the Common Areas deemed desirable by Landlord. Notwithstanding Section 15 above, upon notice from Landlord, Tenant shall assign
or endorse over to Landlord (or to any party designated by Landlord) all property insurance proceeds payable to Tenant under Tenant’s
insurance with respect to any Leasehold Improvements performed by or for the benefit of Tenant; provided if the estimated cost
to repair such Leasehold Improvements exceeds the amount of insurance proceeds received by Landlord from Tenant’s insurance
carrier, the excess cost of such repairs shall be paid by Tenant to Landlord prior to Landlord’s commencement of repairs.
Within fifteen (15) days of demand. Tenant shall also pay Landlord for any additional excess costs that are determined during the
performance of the repairs to such Leasehold Improvements. In no event shall Landlord be required to spend more for the restoration
of the Premises and Common Areas than the proceeds received by Landlord, whether insurance proceeds or proceeds from Tenant. Landlord
shall not be liable for any inconvenience to Tenant, or injury to Tenant’s business resulting in any way from the Casualty
or the repair thereof. Provided that Tenant is not in Default, during any period of time that all or a material portion of the
Premises is rendered untenantable as a result of a Casualty, the Rent shall abate for the portion of the Premises that is untenantable
and not used by Tenant.

 

    	13

     

    

 

17.          
Condemnation.

 

Either party may terminate this Lease if any
material part of the Premises is taken or condemned for any public or quasi-public use under Law, by eminent domain or private
purchase in lieu thereof (a “Taking”). Landlord shall also have the right to terminate this Lease if there is
a Taking of any portion of the Building or Property which would have a material adverse effect on Landlord’s ability to profitably
operate the remainder of the Building. The terminating party shall provide written notice of termination to the other party within
forty-five (45) days after it first receives notice of the Taking. The termination shall be effective as of the effective date
of any order granting possession to, or vesting legal title in, the condemning authority. If this Lease is not terminated, Base
Rent and Tenant’s Pro Rata Share shall be appropriately adjusted to account for any reduction in the square footage of the
Building or Premises. All compensation awarded for a Taking shall be the property of Landlord. The right to receive compensation,
or proceeds are expressly waived by Tenant, provided, however, Tenant may file a separate claim for Tenant’s Property and
Tenant’s reasonable relocation expenses, provided the filing of the claim does not diminish the amount of Landlord’s
award. If only a part of the Premises is subject to a Taking and this Lease is not terminated. Landlord, with reasonable diligence,
will restore the remaining portion of the Premises as nearly as practicable to the condition immediately prior to the Taking.

 

18.          
Events of Default.

 

In addition to any other default specifically
described in this Lease, each of the following occurrences shall be a “Default”: (a) Tenant’s failure
to pay any portion of Rent when due, if the failure continues for three (3) days after written notice to Tenant (“Monetary
Default”); (b) Tenant’s failure (other than a Monetary Default) to comply with any term, provision, condition or
covenant of this Lease, if the failure is not cured within ten (10) days after written notice to Tenant provided, however, if Tenant’s
failure to comply cannot reasonably be cured within ten (10) days, Tenant shall be allowed additional time (not to exceed sixty
(60) days) as is reasonably necessary to cure the failure so long as Tenant begins the cure within ten (10) days and diligently
pursues the cure to completion; (c) Tenant permits a Transfer without Landlord’s required approval or otherwise in violation
of Section 11 of this Lease; (d) Tenant or any Guarantor becomes insolvent, makes a transfer in fraud of creditors, makes an assignment
for the benefit of creditors, admits in writing its inability to pay its debts when due or forfeits or loses its right to conduct
business; (e) the leasehold estate is taken by process or operation of Law; (f) in the case of any ground floor or retail Tenant,
Tenant does not take possession of or abandons or vacates all or any portion of the Premises; or (g) Tenant is in default beyond
any notice and cure period under any other lease or agreement with Landlord at the Building or Property. If Landlord provides Tenant
with notice of Tenant’s failure to comply with any specific provision of this Lease on three (3) separate occasions during
any twelve-(12)-month period, Tenant’s subsequent violation of such provision shall, at Landlord’s option, be an incurable
Default by Tenant. All notices sent under this Section shall be in satisfaction of, and not in addition to, notice required by
Law.

 

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19.          
Remedies.

 

19.01    
Upon Default, Landlord shall have the right to pursue any one or more of the following remedies:

 

(a)           
Terminate this Lease, in which case Tenant shall immediately surrender the Premises to Landlord. If Tenant fails to surrender
the Premises, Landlord, in compliance with Law, may enter upon and take possession of the Premises and remove Tenant, Tenant’s
Property and any party occupying the Premises. Tenant shall pay Landlord, on demand, all past due Rent and other losses and damages
Landlord suffers as a result of Tenant’s Default, including, without limitation, all Costs of Reletting (defined below) and
any deficiency that may arise from reletting or the failure to relet the Premises. “Costs of Reletting” shall
include all reasonable costs and expenses incurred by Landlord in reletting or attempting to relet the Premises, including, without
limitation, legal fees, brokerage commissions, the cost of alterations and the value of other concessions or allowances granted
to a new tenant.

 

(b)          
Terminate Tenant’s right to possession of the Premises and, in compliance with Law, remove Tenant, Tenant’s
Property and any parties occupying the Premises. Landlord may (but shall not be obligated to) relet all or any part of the Premises,
without notice to Tenant, for such period of time and on such terms and conditions (which may include concessions, free rent and
work allowances) as Landlord in its absolute discretion shall determine. Landlord may collect and receive all rents and other income
from the reletting. Tenant shall pay Landlord on demand all past due Rent, all Costs of Reletting and any deficiency arising from
the reletting or failure to relet the Premises. The re-entry or taking of possession of the Premises shall not be construed as
an election by Landlord to terminate this Lease.

 

19.02    
In lieu of calculating damages under Section 19.01, Landlord may elect to receive as damages the sum of (a) all Rent accrued
through the date of termination of this Lease or Tenant’s right to possession, and (b) an amount equal to the total Rent
that Tenant would have been required to pay for the remainder of the Term discounted to present value at the Prime Rate (defined
below) then in effect, minus the then present fair rental value of the Premises for the remainder of the Term, similarly discounted,
after deducting all anticipated Costs of Reletting. “Prime Rate” shall be the per annum interest rate publicly
announced as its prime or base rate by a federally insured bank selected by Landlord in the state in which the Building is located.

 

19.03    
If Tenant is in Default of any of its non-monetary obligations under this Lease, Landlord shall have the right to perform
such obligations. Tenant shall reimburse Landlord for the cost of such performance upon demand together with an administrative
charge equal to ten percent (10%) of the cost of the work performed by Landlord. The repossession or re-entering of all or any
part of the Premises shall not relieve Tenant of its liabilities and obligations under this Lease. No right or remedy of Landlord
shall be exclusive of any other right or remedy. Each right and remedy shall be cumulative and in addition to any other right and
remedy now or subsequently available to Landlord at Law or in equity.

 

    	15

     

    

 

20.          
Limitation of Liability.

 

NOTWITHSTANDING ANYTHING TO THE CONTRARY CONTAINED
IN THIS LEASE, THE LIABILITY OF LANDLORD (AND OF ANY SUCCESSOR LANDLORD) SHALL BE LIMITED TO THE LESSER OF (A) THE INTEREST OF
LANDLORD IN THE PROPERTY, OR (B) THE EQUITY INTEREST LANDLORD WOULD HAVE IN THE PROPERTY IF THE PROPERTY WERE ENCUMBERED BY THIRD
PARTY DEBT IN AN AMOUNT EQUAL TO SEVENTY PERCENT (70%) OF THE VALUE OF THE PROPERTY. TENANT SHALL LOOK SOLELY TO LANDLORD’S
INTEREST IN THE PROPERTY FOR THE RECOVERY OF ANY JUDGMENT OR AWARD AGAINST LANDLORD OR ANY LANDLORD RELATED PARTY. NEITHER LANDLORD
NOR ANY LANDLORD RELATED PARTY SHALL BE PERSONALLY LIABLE FOR ANY JUDGMENT OR DEFICIENCY, AND IN NO EVENT SHALL LANDLORD OR ANY
LANDLORD RELATED PARTY BE LIABLE TO TENANT FOR ANY LOST PROFIT, DAMAGE TO OR LOSS OF BUSINESS OR ANY FORM OF SPECIAL, INDIRECT
OR CONSEQUENTIAL DAMAGE. BEFORE FILING SUIT FOR AN ALLEGED DEFAULT BY LANDLORD, TENANT SHALL GIVE LANDLORD AND THE MORTGAGEE(S)
WHOM TENANT HAS BEEN NOTIFIED HOLD MORTGAGES (DEFINED IN SECTION 23 BELOW), NOTICE AND REASONABLE TIME TO CURE THE ALLEGED DEFAULT.
WITHOUT LIMITING THE FOREGOING, IN NO EVENT SHALL LANDLORD OR ANY MORTGAGEES OR LANDLORD RELATED PARTIES EVER BE LIABLE FOR ANY
CONSEQUENTIAL OR INCIDENTAL DAMAGES OR ANY LOST PROFITS OF TENANT.

 

21.          
Intentionally Omitted.

 

22.          
Holding Over.

 

If Tenant fails to surrender all or any part
of the Premises at the termination of this Lease, occupancy of the Premises after termination shall be that of a tenancy at sufferance.
Tenant’s occupancy shall be subject to all the terms and provisions of this Lease, and Tenant shall pay an amount (on a per
month basis without reduction for partial months during the holdover) equal to one hundred fifty percent (150%) of the sum of the
Base Rent and Additional Rent due for the period immediately preceding the holdover. No holdover by Tenant or payment by Tenant
after the termination of this Lease shall be construed to extend the Term or prevent Landlord from immediate recovery of possession
of the Premises by summary proceedings or otherwise. If Landlord is unable to deliver possession of the Premises to a new tenant
or to perform improvements for a new tenant as a result of Tenant’s holdover and Tenant fails to vacate the Premises within
fifteen (15) days after notice from Landlord, Tenant shall be liable for all damages that Landlord suffers from the holdover.

 

23.          
Subordination to Mortgages; Estoppel Certificate.

 

23.01    
Tenant accepts this Lease subject and subordinate to any mortgage(s), deed(s) of trust, deeds to secure debt, ground lease(s)
or other lien(s) now or subsequently arising upon the Premises, the Building or the Property, and to renewals, modifications, refinancings
and extensions thereof (collectively referred to as a “Mortgage”). The party having the benefit of a Mortgage
shall be referred to as a “Mortgagee”. This clause shall be self-operative, but upon request from a Mortgagee,
Tenant shall execute a commercially reasonable subordination agreement in favor of the Mortgagee. As an alternative, a Mortgagee
shall have the right at any time to subordinate its Mortgage to this Lease. Upon request, Tenant, without charge, shall attorn
to any successor to Landlord’s interest in this Lease. Landlord and Tenant shall each, within ten (10) days after receipt
of a written request from the other, execute and deliver a commercially reasonable estoppel certificate to those parties as are
reasonably requested by the other (including a Mortgagee or prospective purchaser). Without limitation, such estoppel certificate
may include a certification as to the status of this Lease, the existence of any defaults and the amount of Rent that is due and
payable.

 

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23.02    
In the event Mortgagee enforces it rights under the Mortgage, Tenant, at Mortgagee’s option, will attorn to Mortgagee
or its successor; provided, however, that Mortgagee or its successor shall not be liable for or bound by (i) any payment of any
Rent installment which may have been made more than thirty (30) days before the due date of such installment, (ii) any act or omission
of or default by Landlord under this Lease (but Mortgagee, or such successor, shall be subject to the continuing obligations of
landlord under the Lease to the extent arising from and after such succession to the extent of Mortgagee’s, or such successor’s,
interest in the Property), (iii) any credits, claims, setoffs or defenses which Tenant may have against Landlord or (iv) any obligation
under this Lease to maintain a fitness facility at the Building, if any. Tenant, upon the reasonable request by Mortgagee or such
successor in interest, shall execute and deliver an instrument or instruments confirming such attornment.

 

24.          
Notice.

 

All demands, approvals, consents or notices
(collectively referred to as a “notice”) shall be in writing and delivered by hand or sent by registered, express,
or certified mail, with return receipt requested or with delivery confirmation requested from the U.S. postal service, or sent
by overnight or same day courier service at the party’s respective Notice Address(es) set forth in Section 1; provided, however,
notices sent by Landlord regarding general Building operational matters may be posted in the Building mailroom or the general Building
newsletter or sent via e- mail to the e-mail address provided by Tenant to Landlord for such purpose. In addition, if the Building
is closed (whether due to emergency, governmental order or any other reason), then any notice address at the Building shall not
be deemed a required notice address during such closure, and, unless Tenant has provided an alternative valid notice address to
Landlord for use during such closure, any notices sent during such closure may be sent via e-mail or in any other practical manner
reasonably designed to ensure receipt by the intended recipient. Each notice shall be deemed to have been received on the earlier
to occur of actual delivery or the date on which delivery is refused, or, if Tenant has vacated the Premises or any other Notice
Address of Tenant without providing a new Notice Address, three (3) days after notice is deposited in the U.S. mail or with a courier
service in the manner described above. Either party may, at any time, change its Notice Address (other than to a post office box
address) by giving the other party written notice of the new address.

 

25.          
Surrender of Premises.

 

At the termination of this Lease or Tenant’s
right of possession, Tenant shall remove Tenant’s Property from the Premises, and quit and surrender the Premises to Landlord,
broom clean, and in good order, condition and repair, ordinary wear and tear and damage which Landlord is obligated to repair hereunder
excepted. If Tenant fails to remove any of Tenant’s Property, or to restore the Premises to the required condition, within
two (2) days after termination of this Lease or Tenant’s right to possession. Landlord, at Tenant’s sole cost and expense,
shall be entitled (but not obligated) to remove and store Tenant’s Property and/or perform such restoration of the Premises.
Landlord shall not be responsible for the value, preservation or safekeeping of Tenant’s Property. Tenant shall pay Landlord,
upon demand, the expenses and storage charges incurred. If Tenant fails to remove Tenant’s Property from the Premises or
storage, within thirty (30) days after notice, Landlord may deem all or any part of Tenant’s Property to be abandoned and,
at Landlord’s option, title to Tenant’s Property shall vest in Landlord or Landlord may dispose of Tenant’s Property
in any manner Landlord deems appropriate.

 

    	17

     

    

 

26.          
Miscellaneous.

 

26.01    
This Lease shall be interpreted and enforced in accordance with the Laws of the state or commonwealth in which the Building
is located and Landlord and Tenant hereby irrevocably consent to the jurisdiction and proper venue of such state or commonwealth,
If any term or provision of this Lease shall to any extent be void or unenforceable, the remainder of this Lease shall not be affected.
If there is more than one Tenant or if Tenant is comprised of more than one party or entity, the obligations imposed upon Tenant
shall be joint and several obligations of all the parties and entities, and requests or demands from any one person or entity comprising
Tenant shall be deemed to have been made by all such persons or entities. Notices to any one person or entity shall be deemed to
have been given to all persons and entities. Tenant represents and warrants to Landlord, and agrees, that each individual executing
this Lease on behalf of Tenant is authorized to do so on behalf of Tenant and that the entity(ies) or individual(s) constituting
Tenant or Guarantor or which may own or control Tenant or Guarantor or which may be owned or controlled by Tenant or Guarantor
are not and at no time will be (i) in violation of any Laws relating to terrorism or money laundering, or (ii) among the individuals
or entities identified on any list compiled pursuant to Executive Order 13224 for the purpose of identifying suspected terrorists
or on the most current list published by the U.S. Treasury Department Office of Foreign Assets Control at its official website,
http://www.treasury.gov/resource-center/sanctions/SDN-List/‌Pages/default.aspx or any replacement website or other replacement
official publication of such list.

 

26.02    
If Landlord retains an attorney or institutes legal proceedings due to Tenant’s failure to pay Rent when due, then
Tenant shall be required to pay Additional Rent in an amount equal to the reasonable attorneys’ fees and costs actually incurred
by Landlord in connection therewith. Notwithstanding the foregoing, in any action or proceeding between Landlord and Tenant, including
any appellate or alternative dispute resolution proceeding, the prevailing party shall be entitled to recover from the non-prevailing
party all of its costs and expenses in connection therewith, including, but not limited to, reasonable attorneys’ fees actually
incurred. Landlord and Tenant hereby waive any right to trial by jury in any proceeding based upon a breach of this Lease. No failure
by either party to declare a default immediately upon its occurrence, nor any delay by either party in taking action for a default,
nor Landlord’s acceptance of Rent with knowledge of a default by Tenant, shall constitute a waiver of the default, nor shall
it constitute an estoppel.

 

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26.03    
Whenever a period of time is prescribed for the taking of an action by Landlord or Tenant (other than the payment of the
Security Deposit or Rent), the period of time for the performance of such action shall be extended by the number of days that the
performance is actually delayed due to strikes, acts of God, shortages of labor or materials, war, terrorist acts, pandemics, civil
disturbances and other causes beyond the reasonable control of the performing party (“Force Majeure”).

 

26.04    
Landlord shall have the right to transfer and assign, in whole or in part, all of its rights and obligations under this
Lease and in the Building and Property. Upon transfer, Landlord shall be released from any further obligations hereunder and Tenant
agrees to look solely to the successor in interest of Landlord for the performance of such obligations, provided that any successor
pursuant to a voluntary, third party transfer (but not as part of an involuntary transfer resulting from a foreclosure or deed
in lieu thereof) shall have assumed Landlord’s obligations under this Lease from and after the date of the transfer.

 

26.05    
Landlord has delivered a copy of this Lease to Tenant for Tenant’s review only and the delivery of it does not constitute
an offer to Tenant or an option. Tenant represents that it has dealt directly with and only with the Broker (described in Section
1.10) as a broker, agent or finder in connection with this Lease. Tenant shall indemnify and hold Landlord and the Landlord Related
Parties harmless from all claims of any other brokers, agents or finders claiming to have represented Tenant in connection with
this Lease. Landlord shall indemnify and hold Tenant and the Tenant Related Parties harmless from all claims of any brokers, agents
or finders claiming to have represented Landlord in connection with this Lease.

 

26.06    
Time is of the essence with respect to Tenant’s exercise of any expansion, renewal or extension rights granted to
Tenant. The expiration of the Term, whether by lapse of time, termination or otherwise, shall not relieve either party of any obligations
which accrued prior to or which may continue to accrue after the expiration or termination of this Lease.

 

26.07    
Tenant may peacefully have, hold and enjoy the Premises, subject to the terms of this Lease, provided Tenant pays the Rent
and fully performs all of its covenants and agreements. This covenant shall be binding upon Landlord and its successors only during
its or their respective periods of ownership of the Building.

 

26.08    
This Lease does not grant any rights to light or air over or about the Building. Landlord excepts and reserves exclusively
to itself any and all rights not specifically granted to Tenant under this Lease. Landlord reserves the right to make changes to
the Property, Building and Common Areas as Landlord deems appropriate. This Lease constitutes the entire agreement between the
parties and supersedes all prior agreements and understandings related to the Premises, including all lease proposals, letters
of intent and other documents. Neither party is relying upon any warranty, statement or representation not contained in this Lease.
This Lease may be modified only by a written agreement signed by an authorized representative of Landlord and Tenant. Wherever
this Lease requires Landlord to provide a customary service or to act in a reasonable manner (whether in incurring an expense,
establishing a rule or regulation, providing an approval or consent, or performing any other act), this Lease shall be deemed also
to provide that whether such service is customary or such conduct is reasonable shall be determined by reference to the practices
of owners of buildings that (i) are comparable to the Building in size, age, class, quality and location, and (ii) at Landlord’s
option, have been, or are being prepared to be, certified under the U.S. Green Building Council’s Leadership in Energy and
Environmental Design (LEED) rating system or a similar rating system.

 

    	19

     

    

 

26.09    
Submission of this Lease by Landlord is not an offer to enter into this Lease but rather is a solicitation for such an offer
by Tenant. Landlord shall not be bound by this Lease until Landlord has executed and delivered the same to Tenant. Tenant agrees
that its execution of this Lease constitutes a firm offer to enter the same, which may not be withdrawn for a period of thirty
(30) days after delivery to Landlord (or such oilier period as may be expressly provided in any other agreement signed by the parties).

 

26.10    
If Landlord is advised by its counsel at any time that any part of the payments by Tenant to Landlord under this Lease may
be characterized as unrelated business income under the United States Internal Revenue Code and its regulations, then Tenant shall
enter into any amendment proposed by Landlord to avoid such income, so long as the amendment does not require Tenant to make more
payments or accept fewer services from Landlord, than this Lease provides.

 

26.11    
This Lease may be executed in counterparts and shall constitute an agreement binding on all parties notwithstanding that
all parties are not signatories to the original or the same counterpart provided that all parties are furnished a copy or copies
thereof reflecting the signature of all parties. Transmission of a facsimile or by email of a pdf copy of the signed counterpart
of the Lease shall be deemed the equivalent of the delivery of the original, and any party so delivering a facsimile or pdf copy
of the signed counterpart of the Lease by email transmission shall in all events deliver to the other party an original signature
promptly upon request.

 

26.12    
Landlord shall have no right to relocate Tenant during the initial Term or any extension thereof.

 

26.13    
Concurrent with the execution of this Lease, Tenant shall cause Guarantor to deliver to Landlord one (1) original of the
lease guaranty (“Guaranty”) in the form attached hereto as Exhibit G duly executed on behalf of Guarantor.
Any failure by Guarantor to perform any of its obligations under the Guaranty shall be deemed to be a Default by Tenant of its
obligations under this Lease.

 

Landlord and Tenant have executed this Lease
under seal in two or more counterparts as of the day and year first above written.

 

    	20

     

    

 

 

 

 

 

 

 

    	21

     

    

 

EXHIBIT A

 

OUTLINE AND LOCATION OF PREMISES

 

This Exhibit is attached to and made a part
of the Office Lease Agreement (the “Lease”) by and between HINES GLOBAL REIT RIVERSIDE CENTER, LLC, a
Delaware limited liability company (“Landlord”), and CLEMENTIA PHARMACEUTICALS USA, INC., a Delaware
corporation (“Tenant”), for space in the Building located at 275 Grove Street, Newton, Massachusetts 02466.

 

See attached.

 

 

 

 

 

    	A-1

     

    

 

 

 

 

 

 

    	A-2

     

    

 

EXHIBIT B

 

EXPENSES AND TAXES

 

This Exhibit is attached to and made a part
of the Office Lease Agreement (the “Lease”) by and between HINES GLOBAL REIT RIVERSIDE CENTER, LLC, a
Delaware limited liability company (“Landlord”), and CLEMENTIA PHARMACEUTICALS USA, INC., a Delaware
corporation (“Tenant”), for space in the Building located at 275 Grove Street, Newton, Massachusetts 02466.
Capitalized terms used but not defined herein shall have the meanings given in the Lease.

 

1.             
Payments

 

1.01       
Tenant shall pay tenant’s Pro Rata Shae of the amount, if any, by which Expenses (defined below) for each calendar
year during the Term exceed Expenses for the Base Year (the “Expense Excess”) and also the amount, if any, by
which Taxes (defined below) for each Fiscal Year during the Term exceed Taxes for the Base Year (the “Tax Excess”).
If Expenses or Taxes in any calendar year or Fiscal Year decrease below the amount of Expenses or Taxes for the Base Year, Tenant’s
Pro Rata Share of Expenses or Taxes, as the case may be, for that calendar year or Fiscal Year shall be $0. Landlord shall provide
Tenant with a good faith estimate of the Expense Excess and of the Tax Excess for each calendar year or Fiscal Year during the
Term. On or before the first day of each month, Tenant shall pay to Landlord a monthly installment equal to one-twelfth of Tenant’s
Pro Rata Share of Landlord’s estimate of both the Expense Excess and Tax Excess. If Landlord determines that its good faith
estimate of the Expense Excess or of the Tax Excess was incorrect by a material amount, Landlord may provide Tenant with a revised
estimate. After its receipt of a revised estimate. Tenant’s monthly payments shall be based upon the revised estimate. If
Landlord does not provide Tenant with an estimate of the Expense Excess or the Tax Excess by the first day of a calendar year or
Fiscal Year, as the case may be, Tenant shall continue to pay monthly installments based on the previous year’s estimate(s)
until Landlord provides Tenant with the new estimate. Upon delivery of the new estimate, an adjustment shall be made for any month
for which Tenant paid monthly installments based on the previous year’s estimate. Tenant shall pay Landlord the amount of
any underpayment within thirty (30) days after receipt of the new estimate. Any overpayment shall be refunded to Tenant within
thirty (30) days or credited against the next due future installment(s) of Additional Rent.

 

1.02       
As soon as is practical following the end of each calendar year or Fiscal Year, as the case may be, Landlord shall furnish
Tenant with a statement of the actual Expenses and Expense Excess and the actual Taxes and Tax Excess for the prior calendar year
or Fiscal Year, as the case may be. If the estimated Expense Excess or estimated Tax Excess for the prior calendar year or Fiscal
Year, as the case may be, is more than the actual Expense Excess or actual Tax Excess for the prior calendar year or Fiscal Year,
as the case may be, Landlord shall either provide Tenant with a refund or apply any overpayment by Tenant against Additional Rent
due or next becoming due, provided if the Term expires before the determination of the overpayment, Landlord shall refund any overpayment
to Tenant after first deducting the amount of Rent due. If the estimated Expense Excess or estimated Tax Excess for the prior calendar
year or Fiscal Year, as the case may be, is less than the actual Expense Excess or actual Tax Excess, for such prior calendar year
or Fiscal Year, as the case may be, Tenant shall pay Landlord, within thirty (30) days after its receipt of the statement of Expenses
or Taxes, any underpayment for the prior calendar year or Fiscal Year, as the case may be.

 

    	B-1

     

    

 

2.             
Expenses.

 

2.01       
“Expenses” means all costs and expenses incurred in each calendar year in connection with operating,
maintaining, repairing, and managing the Building and the Property. Landlord shall act in a reasonable manner in incurring Expenses.
Expenses include, without limitation: (a) all labor and labor related costs, including wages, salaries, bonuses, taxes, insurance,
uniforms, training, retirement plans, pension plans and other employee benefits; (b) management fees in an amount equal to three
percent (3%) of the gross revenues from the Building and the Property; (c) the cost of equipping, staffing and operating an on-site
and/or off-site management office for the Building, provided if the management office services one or more other buildings or properties,
the shared costs and expenses of equipping, staffing and operating such management office(s) shall be equitably prorated and apportioned
between the Building and the other buildings or properties; (d) accounting costs; (e) the cost of services; (f) rental and purchase
cost of parts, supplies, tools and equipment; (g) insurance premiums and deductibles; (h) electricity, gas and other utility costs;
and (i) the amortized cost of capital improvements (as distinguished from replacement parts or components installed in the ordinary
course of business) made subsequent to the Base Year which are: (1) intended to effect economies in the operation or maintenance
of the Property, reduce current or future Expenses, enhance the safety or security of the Property or its occupants, or enhance
the environmental sustainability of the Property’s operations, (2) replacements or modifications of nonstructural items
located in the Base Building or Common Areas that are required to keep the Base Building or Common Areas in good condition, or
(3) required under any Law. The cost of capital improvements shall be amortized by Landlord over the lesser of the Payback
Period (defined below) or the useful life of the capital improvement as reasonably determined by Landlord. The amortized cost of
capital improvements may, at Landlord’s option, include actual or imputed interest at the rate that Landlord would reasonably
be required to pay to finance the cost of the capital improvement. “Payback Period” means the reasonably estimated
period of time that it takes for the cost savings resulting from a capital improvement to equal the total cost of the capital improvement.
Landlord, by itself or through an affiliate, shall have the right to directly perform, provide and be compensated for any services
under the Lease. If Landlord incurs Expenses for the Building or Property together with one or more other buildings or properties,
whether pursuant to a reciprocal easement agreement, common area agreement or otherwise, the shared costs and expenses shall be
equitably prorated and apportioned between the Building and Property and the other buildings or properties.

 

2.02       
Expenses shall not include: the cost of capital improvements (except as set forth above); depreciation; principal payments
of mortgage and other non-operating debts of Landlord; the cost of repairs or other work to the extent Landlord is reimbursed by
insurance or condemnation proceeds; costs in connection with leasing space in the Building, including brokerage commissions; lease
concessions, rental abatements and construction allowances granted to specific tenants; costs incurred in connection with the sale,
financing or refinancing of the Building; fines, interest and penalties incurred due to the late payment of Taxes or Expenses;
organizational expenses associated with the creation and operation of the entity which constitutes Landlord; or any penalties or
damages that Landlord pays to Tenant under this Lease or to other tenants in the Building under their respective leases.

 

    	B-2

     

    

 

2.03       
If at any time during a calendar year the Building is not at least ninety-five percent (95%) occupied (or a service provided
by Landlord to tenants of the Building generally is not provided by Landlord to a tenant that provides such service itself, or
any tenant of the Building is entitled to free rent, rent abatement or the like), Expenses shall, at Landlord’s option, be
determined as if the Building had been ninety-five percent (95%) occupied (and all services provided by Landlord to tenants of
the Building generally had been provided by Landlord to all tenants, and no tenant of the Building had been entitled to free rent,
rent abatement or the like) during that calendar year. If Expenses for a calendar year are determined as provided in the prior
sentence. Expenses for the Base Year shall also be determined in such manner. Notwithstanding the foregoing, Landlord may calculate
the extrapolation of Expenses under this Section based on one hundred percent (100%) occupancy and service so long as such percentage
is used consistently for each year of the Term. The extrapolation of Expenses under this Section shall be performed in accordance
with the methodology specified by the Building Owners and Managers Association.

 

3.             
“Taxes” shall mean: (a) all real property taxes and other assessments on the Building and/or Property,
including, but not limited to, gross receipts taxes, assessments for special improvement districts and building improvement districts,
governmental charges, fees and assessments for police, fire, traffic mitigation or other governmental service of purported benefit
to the Property, taxes and assessments levied in substitution or supplementation in whole or in part of any such taxes and assessments
and the Property’s share of any real estate taxes and assessments under any reciprocal easement agreement, common area agreement
or similar agreement as to the Property; (b) all personal property taxes for property that is owned by Landlord and used in connection
with the operation, maintenance and repair of the Property; and (c) all costs and fees incurred in connection with seeking reductions
in any tax liabilities described in (a) and (b), including, without limitation, any costs incurred by Landlord for compliance,
review and appeal of tax liabilities. Without limitation, Taxes shall be determined without regard to any “green building”
credit and shall not include any income, capital levy, transfer, capital stock, gift, estate or inheritance tax. If a change in
Taxes is obtained for any year of the Term during which Tenant paid Tenant’s Pro Rata Share of any Tax Excess, then Taxes
for that year will be retroactively adjusted and Landlord shall provide Tenant with a credit, if any, based on the adjustment.
Likewise, if a change is obtained for Taxes for the Base Year, Taxes for the Base Year shall be restated and the Tax Excess for
all subsequent years shall be recomputed. Tenant shall pay Landlord the amount of Tenant’s Pro Rata Share of any such increase
in the Tax Excess within thirty (30) days after Tenant’s receipt of a statement from Landlord.

 

    	B-3

     

    

 

EXHIBIT C

 

WORK LETTER.

 

This Exhibit is attached to and made a part
of the Office Lease Agreement (the “Lease”) by and between HINES GLOBAL REIT RIVERSIDE CENTER, LLC, a Delaware
limited liability company (“Landlord”), and CLEMENTIA PHARMACEUTICALS USA, INC., a Delaware corporation
(“Tenant”), for space in the Building located at 275 Grove Street, Newton, Massachusetts 02466. Capitalized
terms used but not defined herein shall have the meanings given in the Lease.

 

As used in this Work Letter, the “Premises”
shall be deemed to mean the Premises, as initially defined in the attached Lease.

 

		I.	LANDLORD WORK

 

		1.	Definition: Landlord’s Allowance towards Cost of the Landlord Work.
This Work Letter shall set forth the obligations of Landlord and Tenant with respect to the improvements to be performed pursuant
to this Lease. All improvements described in this Work Letter to be constructed in and upon the Premises by Landlord are hereinafter
referred to collectively as the “Landlord Work”. The Landlord Work consists of (x) Base Building Work, as defined
in the last sentence of Paragraph 3 of this Section 1, and (y) the leasehold improvements to the Premises to be made by Landlord
pursuant to this Work Letter (“Tenant Improvement Work”). It is agreed that: (i) Landlord shall bear the entire
cost of the Base Building Work, and (ii) while the construction of the Tenant Improvement Work is intended to be “turn-key”,
Tenant shall bear the cost of the Tenant Improvement Work, subject to Landlord’s Allowance. Notwithstanding the foregoing,
Landlord and Tenant acknowledge that Plans (hereinafter defined) for the Tenant Improvement Work have not yet been prepared and,
therefore, it is impossible to determine the exact cost of the Tenant Improvement Work at this time. Accordingly, Landlord and
Tenant agree that:

 

		a.	Landlord shall provide an allowance (the “Allowance”) to pay for the cost of
the Tenant Improvement Work, inclusive of the cost of preparing Plans (as hereinafter defined), obtaining permits, and other related
costs (“Permitted Costs”) up to a maximum amount of $362,960.00 (i.e., $40.00 per rentable square foot of the
Premises) (the “Maximum Amount”); and

 

		b.	Tenant shall pay to Landlord the amount, if any (the “Excess Costs”) by which
the cost of the Tenant Improvement Work, including, without limitation, the amount of any applicable state sales or use tax, if
any, and the costs incurred by Landlord in connection with the Tenant Improvement Work for permits, design and construction management
fees (collectively the “Cost of Tenant Improvement Work”) to the extent that it exceeds the Maximum Amount.
Hines Interests Limited Partnership, as manager for Landlord, will charge Landlord a fee equal to four percent (4%) of the hard
and soft costs of the Tenant Improvement Work for its services in managing the design and construction of the Tenant Improvement
Work, and such fee will be included in the Cost of Tenant Improvement Work.

 

    	C-1

     

    

 

		2.	Plans for the Landlord Work. Landlord shall perform the Landlord Work, in accordance
with the plans and specifications and scope of work (the “Plans”) to be prepared by Landlord, which Plans shall
be substantially in accordance with the fit plan dated December 21, 2018, prepared by Sierra Architects (the “Fit Plan”),
which is attached hereto as Exhibit C-l. The Plans shall be subject to Tenant’s written approval, which approval shall
not be unreasonably withheld or conditioned. Tenant shall respond in writing (i.e., by either approving such Plans or disapproving
such Plans and setting forth with specificity Tenant’s reasons for such disapproval) to any request from Landlord to approve
the Plans within three (3) Business Days of Tenant’s receipt of such request. Tenant shall approve the Plans to the extent
that they are consistent with the Fit Plan, and Tenant shall otherwise not unreasonably withhold or conditioned such approval.

 

		3.	Construction Contract: Bids for Major Trades. Landlord shall enter into a direct
contract (“Construction Contract”) for the Landlord Work with JDL Corporate Interiors. In addition, Landlord
shall have the right to select and/or approve of any subcontractors used in connection with the Landlord Work. Landlord shall use
reasonable efforts to obtain at least three (3) competitive bids for each of the Major Trades, as hereinafter defined. “Major
Trades” are listed on Exhibit C-2. Landlord’s supervision or performance of any work for or on behalf of
Tenant shall not be deemed a representation by Landlord that the improvements constructed in accordance with the Plans and any
revisions thereto will be adequate for Tenant’s use. Landlord shall perform the Landlord Work in a good and workmanlike manner,
in compliance with all applicable laws, and Landlord shall be responsible for obtaining all permits required in connection with
such work. Landlord shall give Tenant at least seven (7) days’ notice of the anticipated Substantial Completion Date of the
Landlord Work. As part of the Landlord Work, Landlord shall demise or otherwise separate the Premises from the other tenant spaces
on the floor, including, but not limited to, installing insulated drywall partitions, doors, frames, hardware, window coverings,
and shall segregate all existing HVAC, fire alarm, fire sprinkler, and electrical systems (collectively “Base Building
Work”).

 

		4.	Approval of Estimate of the Cost of the Tenant Improvement Work. After Landlord has
obtained the bids for the Major Trades, Landlord shall provide Landlord’s estimate of the cost of the Tenant Improvement
Work (“Estimate”). The Estimate shall be provided to Tenant on an open book basis (i.e., Landlord shall make
available to Tenant the economic terms of the Construction Contract (including, without limitation, the cost of labor and materials,
contractor’s fees and permit fees), as well as all bids received by Landlord for the Tenant Improvement Work, and reasonable
documentation supporting Landlord’s Estimate of all other Permitted Costs. Within three (3) Business Days thereafter. Tenant
shall either notify Landlord in writing of its approval of the Estimate, or Tenant shall have a one-time right to specify its objections
thereto and any desired changes to the proposed Landlord Work. The cost of revising the Plans, as aforesaid and obtaining a revised
Estimate shall be included in Permitted Costs and in the Cost of Tenant Improvement Work. Any changes proposed by Tenant (other
than those necessary to make the Plans conform to the Fit Plan) shall be subject to Landlord’s approval, which approval shall
not be unreasonably withheld or conditioned. Subject to Landlord’s approval of such revisions, as aforesaid: (i) Landlord
shall have the Plans revised in accordance with the approved revisions, and (ii) Landlord shall submit a revised Estimate to Tenant.
Tenant, within five (5) Business Days, shall notify Landlord in writing whether it desires to proceed with such revisions. If Tenant
fails to approve such revisions and revised Estimate within such five-(5)-Business-Day period; such failure shall be deemed to
be a Tenant Delay. Any delays arising from further changes to the Plans requested by Tenant shall be deemed to be Tenant Delays.

 

    	C-2

     

    

 

		5.	Changes Requested by Tenant. If Tenant shall request any changes to the Plans after
Tenant, as contemplated under Paragraph 4 above, either: (i) approves the Plans and the initial Estimate (or revised Plans and
revised Estimate, as the case may be), or (ii) fails timely to approve the revised Plans and revised Estimate in accordance with
the penultimate sentence of Section 4, then such changes (other than those necessary to make the Plans conform to the Fit Plan)
shall be subject to Landlord’s approval, which approval shall not be unreasonably withheld or conditioned. Landlord shall
have the plans for any approved change prepared and shall submit an Estimate of the costs to be incurred by Landlord in connection
with such proposed change. Such Estimate shall include a breakdown and show direct costs of labor and materials, general conditions,
fees and insurance, each of which Landlord agrees shall not be charged at rates which exceed the percentages payable for such items
for the initial scope of work shown on the Plans. Tenant, within three (3) Business Days, shall notify Landlord in writing whether
it desires to proceed with such change. In the absence of such written authorization. Landlord shall have the option to continue
work on the Premises disregarding the requested revision. As an alternative to the foregoing, and in order to ensure that construction
is not delayed, Tenant may in its sole discretion provide Landlord with approval to proceed with Tenant requested changes prior
to completion of revisions to the Plans therefor on a “time and materials” basis. Any delay in the performance of the
Landlord Work arising from any change proposed by Tenant shall be deemed to be a Tenant Delay, and all costs incurred by Landlord
as the result of any change proposed by Tenant shall be included in Permitted Costs and the Cost of Tenant Improvement Work.

 

		6.	Substantial Completion. “Substantial Completion” of the Landlord
Work shall be deemed to have occurred (and the Landlord Work shall be deemed to be “Substantially Complete”),
on the date that (i) all Landlord Work has been performed in accordance with the terms of this Exhibit C, other than any
details of construction, mechanical adjustment or any other similar matter, the non-completion of which does not materially interfere
with Tenant’s lawful use of, or access to, the Premises for first-class business office use; (ii) Landlord has obtained and
delivered to Tenant a permanent or temporary certificate of occupancy with respect to the Premises, except to the extent the same
cannot be obtained by reason of the incompletion of installations or other work that is the responsibility of Tenant, such as,
but not limited to, the installation and making operational of Tenant’s furniture systems and telecommunications equipment,
in which case Landlord shall obtain the same within a reasonable time after the same can be obtained; and (iii) Landlord satisfies
the Delivery Conditions, as defined in Section 11 below. When Landlord believes the Landlord Work is Substantially Complete, Landlord
shall notify Tenant thereof in writing and Tenant’s and Landlord’s construction representatives shall at a mutually
convenient date and time conduct a joint walk-through of the Premises in order to review the Landlord Work. Notwithstanding anything
to the contrary herein contained, if the Landlord Work is delayed by reason of any Tenant Delay, then the Landlord Work shall be
deemed to be Substantially Complete on the day that Landlord would have achieved Substantial Completion of the Landlord Work but
for such Tenant Delay. Based upon said walk-through, Landlord’s and Tenant’s construction representative shall prepare
a “punch-list.” setting forth any items of the Landlord Work which are incomplete or not in accordance with the Plans
or the requirements hereof, and, subject to Tenant Delays, causes beyond Landlord’s reasonable control and long-lead time
items, Landlord shall complete such “punch-list” items within forty-five (45) days after such joint walk-through.

 

    	C-3

     

    

 

		7.	Tenant Delay. “Tenant Delay,” as used herein, shall mean any actual
delay in the performance of the Landlord Work with respect to the Premises to the extent (i) due to changes in the Plans requested
by Tenant, as set forth in Paragraphs 3 and 4 above, (ii) caused by Tenant through the delay of Tenant in supplying information,
approving plans, specifications or estimates, giving authorizations or otherwise within the time specified herein or in the Lease
for Tenant to take such action (and where no time is so specified, Tenant shall have three (3) Business Days to act), (iii) any
delays arising from long lead time items requested by Tenant and identified by Landlord to Tenant in writing at the time that Landlord
approves such items, (iv) caused by delay on the part of Tenant or its contractors who are permitted access to the Premises prior
to Substantial Completion of the Landlord Work, including, without limitation, the utility companies and other entities furnishing
communications, data processing or other service or equipment), and (v) any delays arising from any default under the Lease by
Tenant or any Tenant Party. Except with respect to Tenant Delays where a Tenant fails to act within a time period which is set
forth in the Lease for Tenant’s action, Tenant shall not be charged with any period of Tenant Delay prior to the time that
Landlord gives Tenant written notice of such Tenant Delay.

 

		8.	This Exhibit shall not be deemed applicable to any additional space added to the Premises at any
time or from time to time, whether by any options under the Lease or otherwise, or to any portion of the original Premises or any
additions to the Premises in the event of a renewal or extension of the original Term of the Lease, whether by any options under
the Lease or otherwise, unless expressly so provided in the Lease or any amendment or supplement to the Lease. As used, in this
Work Letter, the “Premises” shall be deemed to mean the Premises, as initially defined in the attached Lease.

 

    	C-4

     

    

 

		II.	BASE BUILDING WORK

 

Without in any way limiting Landlord’s
obligations to perform the Landlord Work, Landlord shall deliver the Premises to Tenant so that they satisfy the following conditions
(“Delivery Conditions”): free of all tenancies, with all Base Building Systems, as hereinafter defined, serving
the Premises in good working order and condition and in full compliance with all laws, building codes, and ordinances which govern
the use and occupancy of office buildings with respect to the Premises. “Base Building Systems” shall include
the structural portions of the Building, the public restrooms, elevators, and the Building HVAC, mechanical, electrical, plumbing,
fire and life safety systems and equipment located in the internal core of the Building on the floor on which the Premises is located.

 

 

 

 

 

    	C-5

     

    

 

EXHIBIT C-1

 

FIT PLAN

 

See attached.

 

 

 

 

 

 

    	C-1-1

     

    

 

 

 

    	C-1-2

     

    

 

EXHIBIT D

 

commencement letter

 

(EXAMPLE)

 

 

	Date  	 	 
	 	 	 
	Tenant Address 	 	 
	 	 	 
	 	 	 
	 	 	 

 

	Re:		Commencement Letter with respect to that certain Lease dated as of                       , 20__,
by and between HINES GLOBAL REIT RIVERSIDE CENTER, LLC, a Delaware limited liability company, as Landlord, and                       , as
Tenant, for                        rentable square feet on the                        floor of                        Riverside Center located at 275 Grove Street,
Newton, Massachusetts 02466.
	 	 	 
	 	 	Lease Id:                       
	 	 	Business Unit Number:                       

 

Dear                       :

 

In accordance with the terms and conditions
of the above referenced Lease, Tenant accepts possession of the Premises and acknowledges:

 

	 	1.             
The Commencement Date of the Lease is  	 	;
	 	 	 	 
	 	2.             
The Termination Date of the Lease is 	 	.

 

Please acknowledge the foregoing and your acceptance
of possession by signing both counterparts of this Commencement Letter in the space provided and returning a fully executed counterpart
to my attention. Tenant’s failure to execute and return this letter, or to provide written objection to the statements contained
in this letter, within thirty (30) days after the date of this letter shall be deemed an approval by Tenant of the statements contained
herein.

 

Sincerely,

 

_____________________________

Authorized Signatory

 

 

 

    	D-1

     

    

 

Acknowledged and Accepted:

 

	Tenant:  	 	 
	 	 	 
	By:	 	 
	Name:	 	 
	Title:	 	 
	Date:	 	 
	 	 	 

 

 

 

 

 

    	D-2

     

    

 

EXHIBIT E

 

BUILDING RULES AND REGULATIONS

 

This Exhibit is attached to and made a part
of the Office Lease Agreement (the “Lease”) by and between HINES GLOBAL REIT RIVERSIDE CENTER, LLC, a Delaware
limited liability company (“Landlord”), and CLEMENTIA PHARMACEUTICALS USA, INC., a Delaware corporation
(“Tenant”), for space in the Building located at 275 Grove Street, Newton, Massachusetts 02466. Capitalized
terms used but not defined herein shall have the meanings given in the Lease.

 

The following rules and regulations shall apply,
where applicable, to the Premises, the Building, the parking facilities (if any), the Property and the appurtenances. In the event
of a conflict between the following rules and regulations and the remainder of the terms of the Lease, the remainder of the terms
of the Lease shall control.

 

1.             
Sidewalks, doorways, vestibules, halls, stairways and other similar areas shall not be obstructed by Tenant or used by Tenant
for any purpose other than ingress and egress to and from the Premises. No rubbish, litter, trash, or material shall be placed,
emptied, or thrown in those areas. At no time shall Tenant permit Tenant’s employees to loiter in Common Areas or elsewhere
about the Building or Property.

 

2.             
Plumbing fixtures and appliances shall be used only for the purposes for which designed and no sweepings, rubbish, rags
or other unsuitable material shall be thrown or placed in the fixtures or appliances.

 

3.             
No signs, advertisements or notices shall be painted or affixed to windows, doors or other parts of the Building, except
those of such color, size, style and in such places as are first approved in writing by Landlord. All tenant identification and
suite numbers at the entrance to the Premises shall be installed by Landlord, at Tenant’s cost and expense, using the standard
graphics for the Building. Except in connection with the hanging of lightweight pictures and wall decorations, no nails, hooks
or screws shall be inserted into any part of the Premises or Building except by the Building maintenance personnel without Landlord’s
prior approval, which approval shall not be unreasonably withheld.

 

4.             
Landlord may provide and maintain in the first floor (main lobby) of the Building an alphabetical directory board or other
directory device listing tenants and no other directory shall be permitted unless previously consented to by Landlord in writing.

 

5.             
Tenant shall not place any lock(s) on any door in the Premises or Building without Landlord’s prior written consent,
which consent shall not be unreasonably withheld, and Landlord shall have the right at all times to retain and use keys or other
access codes or devices to all locks within and into the Premises. A reasonable number of keys to the locks on the entry doors
in the Premises shall be furnished by Landlord to Tenant at Tenant’s cost and Tenant shall not make any duplicate keys. All
keys shall be returned to Landlord at the expiration or early termination of the Lease.

 

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6.             
All contractors, contractor’s representatives and installation technicians performing work in the Building shall be
subject to Landlord’s prior approval, which approval shall not be unreasonably withheld, and shall be required to comply
with Landlord’s standard rules, regulations, policies and procedures, which may be revised from time to time. Landlord has
no obligation to allow any particular telecommunication service provider to have access to the Building or to the Premises. If
Landlord permits access, Landlord may condition the access upon the payment to Landlord by the service provider of fees assessed
by Landlord in Landlord’s sole discretion.

 

7.             
Movement in or out of the Building of furniture or office equipment, or dispatch or receipt by Tenant of merchandise or
materials requiring the use of elevators, stairways, lobby areas or loading dock areas, shall be performed in a manner and restricted
to hours reasonably designated by Landlord. Tenant shall obtain Landlord’s prior approval by providing a detailed listing
of the activity, including the names of any contractors, vendors or delivery companies, which approval shall not be unreasonably
withheld. Tenant shall assume all risk for damage, injury or loss in connection with the activity.

 

8.             
Landlord shall have the right to approve the weight, size, or location of heavy equipment or articles in and about the Premises,
which approval shall not be unreasonably withheld; provided that approval by Landlord shall not relieve Tenant from liability for
any damage in connection with such heavy equipment or articles.

 

9.             
Corridor doors, when not in use, shall be kept closed.

 

10.          
Tenant shall not: (a) make or permit any improper, objectionable or unpleasant noises or odors in the Building, or otherwise
interfere in any way with other tenants or persons having business with them; (b) solicit business or distribute or cause to be
distributed, in any portion of the Building, handbills, promotional materials or other advertising; or (c) conduct or permit other
activities in the Building that might, in Landlord’s sole opinion, constitute a nuisance.

 

11.          
No animals, except those assisting handicapped persons, shall be brought into the Building or kept in or about the Premises.

 

12.          
No inflammable, explosive or dangerous fluids or substances shall be used or kept by Tenant in the Premises, Building or
about the Property, except for those substances as are typically found in similar premises used for general office purposes and
are being used by Tenant in a safe manner and in accordance with all applicable Laws. Tenant shall not, without Landlord’s
prior written consent, use, store, install, spill, remove, release or dispose of, within or about the Premises or any other portion
of the Property, any asbestos-containing materials or any solid, liquid or gaseous material now or subsequently considered toxic
or hazardous under the provisions of 42 U.S.C. Section 9601 et seq., M.G.L. c. 21C, M.G.L. c. 21E or any other applicable environmental
Law which may now or later be in effect. Tenant shall comply with all Laws pertaining to and governing the use of these materials
by Tenant and shall remain solely liable for the costs of abatement and removal.

 

13.          
Tenant shall not use or occupy the Premises in any manner or for any purpose which might injure the reputation or impair
the present or future value of the Premises or the Building. Tenant shall not use, or permit any part of the Premises to be used
for lodging, sleeping or for any illegal purpose.

 

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14.          
Tenant shall not take any action which would violate Landlord’s labor contracts or which would cause a work stoppage,
picketing, labor disruption or dispute or interfere with Landlord’s or any other tenant’s or occupant’s business
or with the rights and privileges of any person lawfully in the Building (“Labor Disruption”). Tenant shall
take the actions necessary to resolve the Labor Disruption, and shall have pickets removed and, at the request of Landlord, immediately
terminate any work in the Premises that gave rise to the Labor Disruption, until Landlord gives its written consent for the work
to resume. Tenant shall have no claim for damages against Landlord or any of the Landlord Related Parties nor shall the Commencement
Date of the Term be extended as a result of the above actions.

 

15.          
Tenant shall not install, operate or maintain in the Premises or in any other area of the Building, electrical equipment
that would overload the electrical system beyond its capacity for proper, efficient and safe operation as determined solely by
Landlord. Tenant shall not furnish cooling or heating to the Premises, including, without limitation, the use of electric or gas
heating devices, without Landlord’s prior written consent. Tenant shall not use more than its proportionate share of telephone
lines and other telecommunication facilities available to service the Building.

 

16.          
Tenant shall not operate or permit to be operated a coin or token operated vending machine or similar device (including,
without limitation, telephones, lockers, toilets, scales, amusement devices and machines for sale of beverages, foods, candy, cigarettes
and other goods), except for machines for the exclusive use of Tenant’s employees and invitees.

 

17.          
Bicycles and other vehicles are not permitted inside the Building or on the walkways outside the Building, except in areas
designated by Landlord.

 

18.          
Landlord may from time to time adopt systems and procedures for the security and safety of the Building and Property, their
occupants, entry, use and contents. Tenant, its agents, employees, contractors, guests and invitees shall comply with Landlord’s
systems and procedures.

 

19.          
Landlord shall have the right to prohibit the use of the name of the Building or any other publicity by Tenant that in Landlord’s
sole opinion may impair the reputation of the Building or its desirability. Upon written notice from Landlord, Tenant shall refrain
from and discontinue such publicity immediately.

 

20.          
Neither Tenant nor its agents, employees, contractors, guests or invitees shall smoke or permit smoking in the Common Areas,
unless a portion of the Common Areas have been declared a designated smoking area by Landlord, nor shall the above parties allow
smoke from the Premises to emanate into the Common Areas or any other part of the Building. Landlord shall have the right to designate
the Building (including the Premises) as a non¬smoking building.

 

21.          
Landlord shall have the right to designate and approve standard window coverings for the Premises and to establish rules
to assure that the Building presents a uniform exterior appearance. Tenant shall ensure, to the extent reasonably practicable,
that window coverings are closed on windows in the Premises while they are exposed to the direct rays of the sun.

 

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22.          
Deliveries to and from the Premises shall be made only at the times in the areas and through the entrances and exits reasonably
designated by Landlord. Tenant shall not make deliveries to or from the Premises in a manner that might interfere with the use
by any other tenant of its premises or of the Common Areas, any pedestrian use, or any use which is inconsistent with good business
practice.

 

23.          
The work of cleaning personnel shall not be hindered by Tenant after 5:30 P.M., and cleaning work may be done at any time
when the offices are vacant. Windows, doors and fixtures may be cleaned at any time. Tenant shall provide adequate waste and rubbish
receptacles to prevent unreasonable hardship to the cleaning service.

 

 

 

 

 

 

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EXHIBIT F

 

ADDITIONAL PROVISIONS

 

This Exhibit is attached to and made a part
of the Office Lease Agreement (the “Lease”) by and between HINES GLOBAL REIT RIVERSIDE CENTER, LLC, a
Delaware limited liability company (“Landlord”), and CLEMENTIA PHARMACEUTICALS USA, INC., a Delaware
corporation (“Tenant”), for space in the Building located at 275 Grove Street, Newton, Massachusetts 02466.
Capitalized terms used but not defined herein shall have the meanings given in the Lease.

 

		1.	Parking.

 

		1.01.	During the initial Term and any extension thereof. Tenant shall have the right to use up to twenty-seven
(27) unreserved parking spaces in the parking facility garage and surface lots (“Unreserved Parking”) and two
(2) allotted spaces (“Reserved Parking”) in the underground executive parking garage under Building One (the
“Garage”) (collectively, the “Spaces”). The Unreserved Parking shall be on a non-exclusive
first-come, first-served basis, for the use of Tenant and its employees, in the parking facility and surface lots, and the Reserved
Parking shall be in the underground executive parking garage under Building One owned by Landlord that serve the Building (collectively,
the “Parking Facility”). No deductions or allowances shall be made for days when Tenant or any of its employees
does not utilize the Parking Facility or for Tenant utilizing less than all of the Spaces. Tenant shall not have the right to lease
or otherwise use more than the number of reserved and unreserved Spaces set forth above,

 

		1.02.	There is currently no charge for Reserved Parking in the underground executive parking garage.
Landlord reserves the right from time to time to assess a commercially reasonable charge for the use of spaces in the Garage, which
charge, shall reflect the then current rate for parking in the Garage; provided, however, that Landlord agrees not to charge Tenant
for Reserved Parking during the Initial Term of the Lease.

 

		1.03.	Except for particular spaces and areas designated by Landlord for reserved parking, all parking
in the Parking Facility shall be on an unreserved, first-come, first-served basis.

 

		1.04.	Landlord shall not be responsible for money, jewelry, automobiles or other personal property lost
in or stolen from the Parking Facility regardless of whether such loss or theft occurs when the Parking Facility is locked or otherwise
secured. Except as caused by the negligence or willful misconduct of Landlord and without limiting the terms of the preceding sentence,
Landlord shall not be liable for any loss, injury or damage to persons using the Parking Facility or automobiles or other property
therein, it being agreed that, to the fullest extent permitted by law, the use of the Spaces shall be at the sole risk of Tenant
and its employees.

 

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		1.05.	Landlord shall have the right from time to time to designate the location of the Spaces and to
promulgate reasonable rules and regulations regarding the Parking Facility, the Spaces and the use thereof, including, but not
limited to, rules and regulations controlling the flow of traffic to and from various parking areas, the angle and direction of
parking and the like. Tenant shall comply with and cause its employees to comply with all such rules and regulations as well as
all reasonable additions and amendments thereto.

 

		1.06.	Tenant shall not store or permit its employees to store any automobiles in the Parking Facility
without the prior written consent of Landlord. Except for emergency repairs. Tenant and its employees shall not perform any work
on any automobiles while located in the Parking Facility or on the Property. If it is necessary for Tenant or its employees to
leave an automobile in the Parking Facility overnight, Tenant shall provide Landlord with prior notice thereof designating the
license plate number and model of such automobile.

 

		1.07.	Landlord shall have the right to temporarily close the Parking Facility or certain areas therein
in order to perform necessary repairs, maintenance and improvements to the Parking Facility.

 

		1.08.	Tenant shall not assign or sublease any of the Spaces without the consent of Landlord. Landlord
shall have the right to terminate this Parking Agreement with respect to any Spaces that Tenant desires to sublet or assign.

 

		1.09.	Landlord may elect to provide parking cards or keys to control access to the Parking Facility.
In such event, Landlord shall provide Tenant with one card or key for each Space that Tenant is leasing hereunder, provided that
Landlord shall have the right to require Tenant or its employees to place a deposit on such access cards or keys and to pay a fee
for any lost or damaged cards or keys.

 

		1.10.	Landlord hereby reserves the right to enter into a management agreement or lease with an entity
for the Parking Facility (“Parking Facility Operator”). In such event, Tenant, upon request of Landlord, shall
enter into a parking agreement with the Parking Facility Operator and pay the Parking Facility Operator the monthly charge established
hereunder, and Landlord shall have no liability for claims arising through acts or omissions of the Parking Facility Operator unless
caused by Landlord’s negligence or willful misconduct. It is understood and agreed that the identity of the Parking Facility
Operator may change from time to time during the Term. In connection therewith, any parking lease or agreement entered into between
Tenant and a Parking Facility Operator shall be freely assignable by such Parking Facility Operator or any successors thereto.

 

		2.	Extension Option.

 

A.            
Grant of Potion: Conditions. Tenant shall have, subject to the following terms and conditions, the right to extend
the Term (the “Extension Option”) for one (1) additional period of five (5) years, commencing on the day following
the Termination Date of the initial Term, and ending on the fifth (5th) anniversary of the Termination Date (the “Extension
Term”), if:

 

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		(i)	Landlord receives notice of exercise (“Initial Extension Notice”) not less than
twelve (12) full calendar months prior to the expiration of the initial Term, and not more than fifteen (15) full calendar months
prior to the expiration of the initial Term; and

 

		(ii)	Tenant is not in Default under the Lease beyond any applicable cure periods at the time that Tenant
delivers its Initial Extension Notice, or at the time Tenant delivers its Binding Notice (as defined below); and

 

		(iii)	No part of the Premises is sublet (other than pursuant to a Business Transfer) at the time that
Tenant delivers its Initial Extension Notice, or at the time Tenant delivers its Binding Notice; and

 

		(iv)	The Lease has not been assigned (other than pursuant to a Business Transfer, as defined in Article
11 of the Lease) prior to the date that Tenant delivers its Initial Extension Notice, or prior to the date Tenant delivers its
Binding Notice.

 

B.            
Terms Applicable to Premises during Extension Term.

 

		(i)	The Lease of the Premises for the Extension shall be upon all of the same terms and conditions
as set forth in the Lease for the initial Term, except that (a) Tenant shall have no further option to extend the Term, and (b)
the initial Base Rent rate per rentable square foot for the Premises during the Extension Term shall equal the Prevailing Market
rate (hereinafter defined) per rentable square foot for the Premises. Base Rent during the Extension Term may increase in accordance
with the increases assumed in the determination of Prevailing Market rate. Base Rent attributable to the Premises shall be payable
in monthly installments in accordance with the terms and conditions of Article 4 of the Lease. The Base Year for Expenses and the
Base Year for Taxes during the Extension Term shall be the calendar year and fiscal year, respectively, in which the Extension
Term commences.

 

		(ii)	Tenant shall pay Additional Rent (i.e., Taxes and Expenses) for the Premises during the Extension
Term in accordance with the terms of Article 4 of the Lease, and the manner and method in which Tenant reimburses Landlord for
Tenant’s share of Taxes and Expenses and the Base Year, if any, applicable to such matter, shall be some of the factors considered
in determining the Prevailing Market rate for the Extension Term.

 

C.            
Initial Procedure for Determining Prevailing Market. Within thirty (30) days after receipt of Tenant’s Initial
Extension Notice, Landlord shall advise Tenant of the applicable Base Rent rate for the Premises for the Extension Term. Tenant,
within fifteen ( 15) days after the date on which Landlord advises Tenant of the applicable Base Rent rate for the Extension Term,
shall either (i) give Landlord final binding written notice (“Binding Notice”) of Tenant’s exercise of
its Extension Option, or (ii) if Tenant disagrees with Landlord’s determination, provide Landlord with written notice of
rejection (the “Rejection Notice”). If Tenant fails to provide Landlord with either a Binding Notice or Rejection
Notice within such fifteen-(15)-day period, Tenant shall be deemed to have provided a Binding Notice. If Tenant provides or is
deemed to have provided Landlord with a Binding Notice, Landlord and Tenant shall enter into the Extension Amendment (as defined
below) upon the terms and conditions set forth herein. If Tenant provides Landlord with a Rejection Notice, Landlord and Tenant
shall work together in good faith to agree upon the Prevailing Market rate for the Premises during the Extension Term. Upon agreement,
Landlord and Tenant shall enter into the Extension Amendment in accordance with the terms and conditions hereof. Notwithstanding
the foregoing, if Landlord and Tenant fail to agree upon the Prevailing Market rate within thirty (30) days after the date Tenant
provides Landlord with the Rejection Notice, then the Prevailing Market rate shall be determined in accordance with the arbitration
procedures described in Section D below.

 

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D.            
Arbitration Procedure.

 

		(i)	If Landlord and Tenant have failed to reach agreement as to the Prevailing Market rate within thirty
(30) days after the date of the Rejection Notice, then, within five (5) days after the expiration of such thirty-(30)-day period,
Landlord and Tenant shall each simultaneously submit to the other, in a sealed envelope, its good faith estimate of the Prevailing
Market rate for the Premises during the Extension Term (collectively referred to as the “Estimates”). If the
higher of such Estimates is not more than I 05% of the lower of such Estimates, then Prevailing Market rate shall be the average
of the two Estimates. If the Prevailing Market rate is not resolved by the exchange of Estimates, then, within seven (7) days after
the exchange of Estimates, Landlord and Tenant shall each select an appraiser to determine which of the two Estimates most closely
reflects the Prevailing Market rate for the Premises during the Extension Term. Each appraiser so selected shall be certified as
an MAI appraiser or as an ASA appraiser and shall have had at least five (5) years’ experience within the previous ten (10)
years as a real estate appraiser working in the Newton/Wellesley, Massachusetts area, with working knowledge of current rental
rates and practices. For purposes hereof, an “MAI” appraiser means an individual who holds an MAI designation
conferred by, and is an independent member 01: the American Institute of Real Estate Appraisers ( or its successor organization,
or in the event there is no successor organization, the organization and designation most similar), and an “ASA”
appraiser means an individual who holds the Senior Member designation conferred by, and is an independent member of, the American
Society of Appraisers ( or its successor organization, or, in the event there is no successor organization, the organization and
designation most similar).

 

		(ii)	Upon selection, Landlord’s and Tenant’s appraisers shall work together in good faith
to agree upon which of the two Estimates most closely reflects the Prevailing Market rate for the Premises. The Estimate chosen
by such appraisers shall be binding on both Landlord and Tenant as the Base Rent rate for the Premises during the Extension Term.
If either Landlord or Tenant fails to appoint an appraiser within the seven-(7)-day period referred to above, and such failure
continues for three (3) Business Days after written notice thereof, the appraiser appointed by the other party shall be the sole
appraiser for the purposes hereof. If the two appraisers cannot agree upon which of the two Estimates most closely reflects the
Prevailing Market within twenty (20) days after their appointment, then, within ten (10) days after the expiration of such twenty-(20)-day
period, the two appraisers shall select a third appraiser meeting the aforementioned criteria. Once the third appraiser (i.e. arbitrator)
has been selected as provided for above, then, as soon thereafter as practicable but in any case within fourteen (14) days, the
arbitrator shall make his determination of which of the two Estimates most closely reflects the Prevailing Market rate and such
Estimate shall be binding on both Landlord and Tenant as the Base Rent for the Premises. If the arbitrator believes that expert
advice would materially assist him, he may retain one or more qualified persons to provide such expert advice. The parties shall
share equally in the costs of the arbitrator and of any experts retained by the arbitrator. Any fees of any appraiser, counsel
or experts engaged directly by Landlord or Tenant, however, shall be borne by the party retaining such appraiser, counsel or expert.

 

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		(iii)	If the Prevailing Market rate has not been determined by the commencement date of the Extension
Term, Tenant shall pay Base Rent upon the terms and conditions in effect during the last month of the initial Term for the Premises
until such time as the Prevailing Market rate has been determined. Upon such determination, the Base Rent for the Premises shall
be retroactively adjusted to the commencement of the Extension Term for the Premises. If such adjustment results in an underpayment
of Base Rent by Tenant, Tenant shall pay Landlord the amount of such underpayment within thirty (30) days after the determination
thereof.

 

E.            
Extension Amendment. If Tenant is entitled to and properly exercises its Extension Option, Landlord shall prepare
an amendment (the “Extension Amendment”) to reflect changes in the Base Rent, Term, Termination Date and other
appropriate terms. The Extension Amendment shall be sent to Tenant within a reasonable time after receipt of the Binding Notice,
or Rejection Notice, as the case may be, and Tenant shall execute and return the Extension Amendment to Landlord within fifteen
(15) days after Tenant’s receipt of same, but, upon delivery of the Initial Extension Notice, an otherwise valid exercise
of the Extension Option shall be fully effective whether or not the Extension Amendment is executed.

 

F.             
Prevailing Market. For purposes hereof, “Prevailing Market” shall mean the arm’s length
fan- market annual rental rate per rentable square foot under extension leases and amendments entered into on or about the date
on which the Prevailing Market is being determined hereunder for space comparable to the Premises in the Building and office buildings
comparable to the Building in the Newton/Wellesley, Massachusetts area. The determination of Prevailing Market shall take into
account any material economic differences between the terms of this Lease and any comparison lease or amendment, such as rent abatements,
construction costs and other concessions and the manner, if any, in which the landlord under any such lease is reimbursed for operating
expenses and taxes.

 

    	F-5

     

    

 

		3.	Signage. Landlord shall install tenant identification on the ground floor lobby directory
and at the entrance to the Premises, using the standard graphics for the Building. The initial listing of Tenant’s name shall
be at Landlord’s cost and expense. Any changes, replacements or additions by Tenant to such directory shall be at Tenant’s
sole cost and expense.

 

 

 

 

 

 

 

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EXHIBIT G

 

GUARANTY OF LEASE

 

FOR VALUE RECEIVED and in consideration for
and as an inducement to HINES GLOBAL REIT RIVERSIDE CENTER, LLC., a Delaware limited liability company (“Landlord”)
to lease certain real property to CLEMENTIA PHARMACEUTICALS USA, INC., a Delaware corporation, as tenant (“Tenant”),
pursuant to a lease of even date herewith (the “Lease”) by and between Landlord and Tenant, CLEMENTIA PHARMACEUTICALS,
INC., a Quebec corporation (“Guarantor”), does hereby unconditionally and irrevocably guarantee to Landlord
the punctual payment of all Rent (as such term is defined in the Lease) payable by Tenant under the Lease throughout the term of
the Lease and any and all renewals and extensions thereof in accordance with and subject to the provisions of the Lease, and the
full performance and observance of all other terms, covenants, conditions and agreements therein provided to be performed and observed
by Tenant under the terms of the Lease, for which the undersigned shall be jointly and severally liable with Tenant. If any default
on the part of Tenant shall occur under the Lease, the undersigned do hereby covenant and agree to pay to Landlord in each and
every instance such sum or sums of money and to perform each and every covenant, condition and agreement under the Lease as Tenant
is and shall become liable for or obligated to pay or perform under the Lease, together with the costs reasonably incurred by Landlord
in connection therewith, including, without limitation, reasonable attorneys’ fees. Such payments of Rent and other sums
shall be made monthly or at such other intervals as the same shall or may become payable under the Lease, including any accelerations
thereof, all without requiring any notice from Landlord (other than any notice required by the Lease) of such non-payment or non¬performance,
all of which the undersigned hereby expressly waives.

 

The maintenance of any action or proceeding
by Landlord to recover any sum or sums that may be or become due under the Lease and to secure the performance of any of the other
terms, covenants and conditions of the Lease shall not preclude Landlord from thereafter instituting and maintaining subsequent
actions or proceedings for any subsequent default or defaults of Tenant under the Lease. The undersigned does hereby consent that
without affecting the liability of the undersigned under this Guaranty and without notice to the undersigned, time may be given
by Landlord to Tenant for payment of Rent and such other sums and performance of said other terms, covenants and conditions, or
any of them, and such time extended and indulgence granted, from time to time, or Tenant may be dispossessed or Landlord may avail
itself of or exercise any or all of the rights and remedies against Tenant provided by law or by the Lease, and may proceed either
against Tenant alone or jointly against Tenant and the undersigned, or against the undersigned alone without first prosecuting
or exhausting any remedy or claim against Tenant. The undersigned does hereby further consent to any subsequent change, modification
or amendment of the Lease in any of its terms, covenants or conditions, or in the Rent payable thereunder, or in the premises demised
thereby, or in the term thereof, and to any assignment or assignments of the Lease, and to any subletting or sublettings of the
premises demised by the Lease, and to any renewals or extensions thereof, all of which may be made without notice to or consent
of the undersigned and without in any manner releasing or relieving the undersigned from liability under this Guaranty.

 

    	G-1

     

    

 

The undersigned does hereby agree that the bankruptcy
of Tenant shall have no effect on the obligations of the undersigned hereunder. The undersigned does hereby further agree that
in respect of any payments made by the undersigned hereunder, the undersigned shall not have any rights based on suretyship, subrogation
or otherwise to stand in the place of Landlord so as to compete with Landlord as a creditor of Tenant, unless and until all claims
of Landlord under the Lease shall have been fully paid and satisfied.

 

Neither this Guaranty nor any of the provisions
hereof can be modified, waived or terminated, except by a written instrument signed by Landlord and the undersigned. The provisions
of this Guaranty shall apply to, bind and inure to the benefit of the undersigned and Landlord and its legal representatives, successors
and assigns. If Landlord should retain counsel and/or institute any suit against Guarantor to enforce this Guaranty or any covenants
or obligations hereunder, then Guarantor shall pay to Landlord, upon demand, all reasonable attorneys’ fees, costs and expenses,
including, without limitation, court costs, filing fees, recording costs, and all other costs and expenses incurred in connection
therewith (all of which are referred to herein as “Enforcement Costs”), in addition to all other amounts due
hereunder.

 

Guarantor further agrees that the validity of
this Guaranty and the obligations hereunder shall in no way be terminated, affected or impaired by reason of the assertion or waiver
by Landlord of any of the rights or remedies reserved to Landlord pursuant to the terms of the Lease. This Guaranty shall be governed
by and construed in accordance with the internal substantive laws of the Commonwealth of Massachusetts (without regard to the conflict
of law provisions thereof).

 

Guarantor hereby: (i) irrevocably consents and
submits to the jurisdiction of the Superior or District Court of Middlesex (South) County and the United States Federal District
Court for Massachusetts in respect to any action or proceeding brought therein by Landlord against Guarantor concerning any matters
arising out of or in any way relating to this Guaranty or the Lease; (ii) expressly waives any rights of Guarantor pursuant to
the laws of any other jurisdiction by virtue of which exclusive jurisdiction of the courts of any other jurisdiction might be claimed;
(iii) irrevocably waives personal service of any summons and complaint, and consents to the service upon Guarantor of process in
any such action or proceeding by the mailing of such process by first class, registered or certified mail, postage prepaid, to
Guarantor at the address set forth above and hereby irrevocably designates CT Corporation System, with an address of 111 Eight
Avenue, New York, New York, 10011 (“Agent”) to accept service of any process on Guarantor’s behalf and
hereby agrees that such service shall be deemed sufficient; (iv) irrevocably waives all objections as to venue or inconvenient
forum and any and all rights Guarantor may have to seek a change of venue with respect to any such action or proceeding; (v) agrees
that the laws of the Commonwealth of Massachusetts (without giving effect to the conflicts of laws doctrines thereof) shall govern
in any such action or proceeding, and waives any defense to any action or proceeding granted or allowed by the laws of any other
country or jurisdiction unless such defense is also allowed by the laws of the Commonwealth of Massachusetts; and (vi) agrees that
any final judgment rendered against Guarantor in any such action or proceeding shall be conclusive and may be enforced in any other
jurisdiction by suit on the judgment or in any other manner provided by law, and expressly consents to the affirmation of the validity
of any such judgment by the courts of any other jurisdiction so as to permit execution thereon. Guarantor further agrees that any
action or proceeding by Guarantor against Landlord with respect to any matters arising out of or in any way relating to the Lease
shall be brought only in the Superior or District Court of Middlesex (South) County and the United States Federal District Court
for Massachusetts. Guarantor hereby represents and agrees that Guarantor will interpose no defense or claim against and shall consent
to the issuance of all necessary documents by the courts of any other jurisdiction in order to execute upon any such judgment.
Guarantor hereby irrevocably and unconditionally waives, to the fullest extent it may legally and effectively do so, trial by jury
in any action or proceeding arising out of or relating to this Guaranty.

 

    	G-2

     

    

 

Any notice or other communication to be given
to Landlord or the undersigned hereunder shall be in writing and sent in accordance with the notice provisions of the Lease. Notices
to Landlord shall be delivered to Landlord’s address as set forth in the Lease. Notices to the undersigned shall be addressed
as follows:

 

Clementia Pharmaceuticals, Inc.

1000, de la Gauchetière, suite 1200

Montréal, Québec, Canada H3B 4W5

 

If Guarantor’s notice address as set forth
above changes, Guarantor agrees to provide written notice to Landlord of such change in address in accordance with the notice provisions
of the Lease.

 

[BALANCE OF PAGE INTENTIONALLY LEFT BLANK;

SIGNATURE ON FOLLOWING PAGE]

 

 

 

 

 

 

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IN WITNESS WHEREOF, the undersigned has executed
this Guaranty as of the date of the Lease.

 

 

 

 

(Acknowledgement of Guarantor)

 

Province of Quebec

ss:

City of Montreal

 

On the 1st day of February in the year 2019 before me the undersigned,
a notary public in and for said state, personally appeared Steve Forte, personally known to me or proved to me on the basis of
satisfactory evidence to be the individual(s) whose name(s) is (are) subscribed to the within instrument and acknowledged to me
that he/she/they executed the same in his/her/their capacity(ies), and that by his/her/their signature(s) on the instrument, the
corporation upon behalf of which the individual(s) acted, executed the instrument.

 

 

 

 

 

 

 

 

 

G-4EX-4.1

 Exhibit 4.1 

SYNDAX PHARMACEUTICALS, INC. 

WARRANT TO PURCHASE COMMON STOCK 
  

			
	 	  	 Number of Shares:
[                ]
 (subject to adjustment)

	 Series [1][2] Warrant No. [1][2][-[         ]
	  	Original Issue Date: [                ]

 Syndax Pharmaceuticals, Inc., a Delaware corporation (the “Company”), hereby certifies that,
for good and valuable consideration, the receipt and sufficiency of which are hereby acknowledged, [             ]. or its permitted registered assigns (the “Holder”), is
entitled, subject to the terms set forth below, to purchase from the Company up to a total of [             ] shares of common stock, $0.0001 par value per share (the “Common
Stock”), of the Company (each such share, a “Warrant Share” and all such shares, the “Warrant Shares”) at an exercise price per share equal to
$             per share (as adjusted from time to time as provided in Section 9 herein, the “Exercise Price”), upon surrender of this Warrant to
Purchase Common Stock (including any Warrants to Purchase Common Stock issued in exchange, transfer or replacement hereof, the “Warrant”) at any time and from time to time on or after the date hereof (the “Original Issue
Date”) and through and including 5:30 P.M., New York City time, on Expiration Date (as defined herein), and subject to the following terms and conditions: 
  

	1.	 Definitions. For purposes of this Warrant, the following terms shall have the following meanings:

 (a)    “Affiliate” means any Person directly or indirectly controlled by,
controlling or under common control with, a Holder, but only for so long as such control shall continue. For purposes of this definition, “control” (including, with correlative meanings, “controlled by,” “controlling”
and “under common control with”) means, with respect to a Person, possession, direct or indirect, of (a) the power to direct or cause direction of the management and policies of such Person (whether through ownership of securities or
partnership or other ownership interests, by contract or otherwise), or (b) at least 50% of the voting securities (whether directly or pursuant to any option, warrant or other similar arrangement) or other comparable equity interests. 

(b)    “Commission” means the United States Securities and Exchange Commission. 

(c)    “Closing Sale Price” means, for any security as of any date, the last trade price for such
security on the Principal Trading Market for such security, as reported by Bloomberg Financial Markets, or, if such Principal Trading Market begins to operate on an extended hours basis and does not designate the last trade price, then the last
trade price of such security prior to 4:00 P.M., New York City time, as reported by Bloomberg Financial Markets, or if the foregoing do not apply, the last trade price of such security in the over-the-counter market on the electronic bulletin board for such security as reported by Bloomberg Financial Markets, or, if no last trade price is reported for such security by Bloomberg Financial Markets,
the average of the bid and ask prices, of any market makers for such security as reported in the “pink sheets” by Pink Sheets LLC. If the Closing Sale Price cannot be calculated for a security on a particular date on any of the foregoing
bases, the Closing Sale Price of such security on such date shall be the fair market value as mutually determined by the Company and the Holder. If the Company and the Holder are unable to agree upon the fair market value of such security, then the
Board of Directors of the Company shall use its good faith judgment to determine the fair market value. The Board of Directors’ determination shall be binding upon all parties absent demonstrable error. All such determinations shall be
appropriately adjusted for any stock dividend, stock split, stock combination or other similar transaction during the applicable calculation period. 

(d)    “Principal Trading Market” means the national securities exchange or other trading market on which
the Common Stock is primarily listed on and quoted for trading, which, as of the Original Issue Date, shall be The Nasdaq Global Select Market. 
  

	 	(e)	 “Securities Act” means the Securities Act of 1933, as amended. 

 

	 	(f)	 “Trading Day” means any weekday on which the Principal Trading Market is open for trading.

 (g)    “Transfer Agent” means Computershare Trust Company, N.A., the
Company’s transfer agent and registrar for the Common Stock, and any successor appointed in such capacity. 

  
 1 

 2.    Registration of Warrants. The Company shall register this Warrant, upon
records to be maintained by the Company for that purpose (the “Warrant Register”), in the name of the record Holder (which shall include the initial Holder or, as the case may be, any registered assignee to which this Warrant is
permissibly assigned hereunder) from time to time. The Company may deem and treat the registered Holder of this Warrant as the absolute owner hereof for the purpose of any exercise hereof or any distribution to the Holder, and for all other
purposes, absent actual notice to the contrary. 
 3.    Registration of Transfers. Subject to compliance with all applicable
securities laws, the Company shall, or will cause its Transfer Agent to, register the transfer of all or any portion of this Warrant in the Warrant Register, upon surrender of this Warrant, and payment for all applicable transfer taxes (if any).
Upon any such registration or transfer, a new warrant to purchase Common Stock in substantially the form of this Warrant (any such new warrant, a “New Warrant”) evidencing the portion of this Warrant so transferred shall be issued
to the transferee, and a New Warrant evidencing the remaining portion of this Warrant not so transferred, if any, shall be issued to the transferring Holder. The acceptance of the New Warrant by the transferee thereof shall be deemed the acceptance
by such transferee of all of the rights and obligations in respect of the New Warrant that the Holder has in respect of this Warrant. The Company shall, or will cause its Transfer Agent to, prepare, issue and deliver at the Company’s own
expense any New Warrant under this Section 3. Until due presentment for registration of transfer, the Company may treat the registered Holder hereof as the owner and holder for all purposes, and the Company shall not be
affected by any notice to the contrary. 
 4.     Exercise and Duration of Warrants. 

(a)    This Warrant shall expire on the earlier of (i) 90 days following the Company’s certification to the Holder
that the Company has publicly released positive data confirming that it has achieved the specified primary endpoint of overall survival benefit in the Company’s E2112 clinical trial in breast cancer patients, or (ii) December 31,
2020 (the “Expiration Date”). All or any part of this Warrant shall be exercisable by the registered Holder in any manner permitted by Section 10 of this Warrant at any time and from time to time on or
after the Original Issue Date and through and including 5:30 P.M. New York City time, on the Expiration Date. At 5:30 P.M., New York City time, on the Expiration Date, the portion of this Warrant not exercised prior thereto shall be and become void
and of no value and this Warrant shall be terminated and no longer outstanding. 
 (b)    The Holder may exercise this
Warrant by delivering to the Company (i) an exercise notice, in the form attached as Schedule 1 hereto (the “Exercise Notice”), completed and duly signed, and (ii) payment of the Exercise Price for the number of
Warrant Shares as to which this Warrant is being exercised (which may take the form of a “cashless exercise” if so indicated in the Exercise Notice pursuant to Section 10 below), and the date on which the last of
such items is delivered to the Company (as determined in accordance with the notice provisions hereof) is an “Exercise Date.” The Holder shall not be required to deliver the original Warrant in order to effect an exercise hereunder.
Execution and delivery of the Exercise Notice shall have the same effect as cancellation of the original Warrant and issuance of a New Warrant evidencing the right to purchase the remaining number of Warrant Shares. 

5.     Delivery of Warrant Shares. 

(a)    Upon exercise of this Warrant, the Company shall promptly (but in no event later than two Trading Days after the
Exercise Date), upon the request of the Holder, credit such aggregate number of shares of Common Stock to which the Holder is entitled pursuant to such exercise to the Holder’s or its designee’s balance account with The Depository Trust
Company (“DTC”) through its Deposit Withdrawal Agent Commission system, or if the Transfer Agent is not participating in the Fast Automated Securities Transfer Program (the “FAST Program”) or if the certificates are
required to bear a legend regarding restriction on transferability, issue and dispatch by overnight courier to the address as specified in the Exercise Notice, a certificate, registered in the Company’s share register in the name of the Holder
or its designee, for the number of shares of Common Stock to which the Holder is entitled pursuant to such exercise. The Holder, or any natural person or legal entity (each, a “Person”) permissibly so designated by the Holder to
receive Warrant Shares, shall be deemed to have become the holder of record of such Warrant Shares as of the Exercise Date, irrespective of the date such Warrant Shares are credited to the Holder’s DTC account or the date of delivery of the
certificates evidencing such Warrant Shares, as the case may be. 
 (b)    If by the close of the second Trading Day
after the Exercise Date, the Company fails to deliver to the Holder a certificate representing the required number of Warrant Shares in the manner required pursuant to Section 5(a) or fails to credit the Holder’s
balance account with DTC for such number of Warrant Shares to which the Holder is entitled, and if after such second Trading Day and prior to the receipt of such Warrant Shares, the Holder purchases (in an open market transaction or otherwise)
shares of Common Stock to deliver in satisfaction of a sale by the Holder of the Warrant Shares which the Holder anticipated receiving upon such exercise (a “Buy-In”), then the Company shall,
within two Trading Days after the Holder’s 

  
 2 

 
request and in the Holder’s sole discretion, either (1) pay in cash to the Holder an amount equal to the Holder’s total purchase price (including brokerage commissions, if any) for
the shares of Common Stock so purchased (the “Buy-In Price”), at which point the Company’s obligation to deliver such certificate (and to issue such Warrant Shares) shall terminate or
(2) promptly honor its obligation to deliver to the Holder a certificate or certificates representing such Warrant Shares and pay cash to the Holder in an amount equal to the excess (if any) of Holder’s total purchase price (including
brokerage commissions, if any) for the shares of Common Stock so purchased in the Buy-In over the product of (A) the number of shares of Common Stock purchased in the
Buy-In, times (B) the Closing Sale Price of a share of Common Stock on the Exercise Date. 

(c)    To the extent permitted by law and subject to 5(b), the Company’s obligations to issue and deliver Warrant
Shares in accordance with and subject to the terms hereof (including the limitations set forth in Section 11 below) are absolute and unconditional, irrespective of any action or inaction by the Holder to enforce the same,
any waiver or consent with respect to any provision hereof, the recovery of any judgment against any Person or any action to enforce the same, or any setoff, counterclaim, recoupment, limitation or termination, or any breach or alleged breach by the
Holder or any other Person of any obligation to the Company or any violation or alleged violation of law by the Holder or any other Person, and irrespective of any other circumstance that might otherwise limit such obligation of the Company to the
Holder in connection with the issuance of Warrant Shares. Subject to Section 5(b), nothing herein shall limit the Holder’s right to pursue any other remedies available to it hereunder, at law or in equity including, without limitation, a
decree of specific performance and/or injunctive relief with respect to the Company’s failure to timely deliver certificates representing shares of Common Stock upon exercise of the Warrant as required pursuant to the terms hereof. 

6.    Charges, Taxes and Expenses. Issuance and delivery of certificates for shares of Common Stock upon exercise of this Warrant
shall be made without charge to the Holder for any issue or transfer tax, transfer agent fee or other incidental tax or expense (excluding any applicable stamp duties) in respect of the issuance of such certificates, all of which taxes and expenses
shall be paid by the Company; provided, however, that the Company shall not be required to pay any tax that may be payable in respect of any transfer involved in the registration of any certificates for Warrant Shares or the Warrants in a
name other than that of the Holder or an Affiliate thereof. The Holder shall be responsible for all other tax liability that may arise as a result of holding or transferring this Warrant or receiving Warrant Shares upon exercise hereof. 

7.    Replacement of Warrant. If this Warrant is mutilated, lost, stolen or destroyed, the Company shall issue or cause to be
issued in exchange and substitution for and upon cancellation hereof, or in lieu of and substitution for this Warrant, a New Warrant, but only upon receipt of evidence reasonably satisfactory to the Company of such loss, theft or destruction (in
such case) and, in each case, a customary and reasonable indemnity and surety bond, if requested by the Company. Applicants for a New Warrant under such circumstances shall also comply with such other reasonable regulations and procedures and pay
such other reasonable third-party costs as the Company may prescribe. If a New Warrant is requested as a result of a mutilation of this Warrant, then the Holder shall deliver such mutilated Warrant to the Company as a condition precedent to the
Company’s obligation to issue the New Warrant. 
 8.    Reservation of Warrant Shares. The Company covenants that it will at
all times while this Warrant is outstanding reserve and keep available out of the aggregate of its authorized but unissued and otherwise unreserved Common Stock, solely for the purpose of enabling it to issue Warrant Shares upon exercise of this
Warrant as herein provided, the number of Warrant Shares that are initially issuable and deliverable upon the exercise of this entire Warrant, free from preemptive rights or any other contingent purchase rights of persons other than the Holder
(taking into account the adjustments and restrictions of Section 9). The Company covenants that all Warrant Shares so issuable and deliverable shall, upon issuance and the payment of the applicable Exercise Price in
accordance with the terms hereof, be duly and validly authorized, issued and fully paid and nonassessable. The Company will take all such action as may be reasonably necessary to assure that such shares of Common Stock may be issued as provided
herein without violation of any applicable law or regulation, or of any requirements of any securities exchange or automated quotation system upon which the Common Stock may be listed. 

9.    Certain Adjustments. The number of Warrant Shares issuable upon exercise of this Warrant is subject to adjustment from time
to time as set forth in this Section 9. 

(a)    One-Time Exercise Price Adjustment. If, prior to the Expiration
Date, the Company sells shares of capital stock or derivative securities convertible into or exercisable for capital stock (other than Exempted Securities) in one or more related transactions primarily for the purpose of raising capital (each, a
“Subsequent Offering”) at a Weighted-Average Price below $12.00 per share (as may be adjusted by paragraphs (b) through (g)), then the initial Exercise Price of this Warrant (the “Initial Exercise Price”) will
be automatically reset upon exercise of this Warrant to an exercise price (the “Adjusted Exercise Price”) that is the midpoint between the Initial Exercise Price and the lowest Weighted-Average Price per share at which the Company

  
 3 

 
sells capital stock or derivative securities convertible into or exercisable for capital stock in a Subsequent Offering prior to the exercise date; provided, however, that the
Adjusted Exercise Price will not be reduced below $6.00 per share. For purposes of this Section 9(a), the “Weighted-Average Price” shall be calculated as the weighted-average common stock equivalent price of the equity securities sold
in such transaction(s) (excluding any derivative securities with an exercise or conversion price that is above the Closing Sale Price as of the time of pricing such offering(s)). For example, if the Company were to conduct a capital raising
transaction where it sold 100 shares of Common Stock at $8.00 per share, but also provided 25% warrant coverage with an exercise price of $6.00 per share, then the weighted average common stock equivalent price would be $7.60 per share (i.e., $950
in total potential proceeds, divided by 125 total potential shares), and the Adjusted Exercise Price would equal midpoint between the Initial Exercise Price and $7.60 per share (rounded up to the nearest cent). In no event will the exercise price
for this Warrant be adjusted more than once pursuant to this Section 9(a). “Exempted Securities” means (a) shares of Common Stock or rights, warrants or options to purchase Common Stock issued in connection with any
acquisition of another corporation by the Company by merger, purchase of substantially all of the assets or other reorganization or to a joint venture agreement, provided that such issuances are approved by the Board of Directors, (b) equity
securities issued by reason of a dividend, stock split, split-up or other distribution on shares of Common Stock, (c) shares of Common Stock or rights, warrants or options to purchase Common Stock issued
to employees or directors of, or consultants or advisors to, the Company or any of its subsidiaries pursuant to a plan, agreement or arrangement approved by the Board of Directors (“Equity Plans”), (d) shares of Common Stock issued
upon the exercise of options or upon the conversion or exchange of any securities convertible into Common Stock, including any pre-funded warrants outstanding as of the Original Issue Date, any pre-funded warrants to be issued pursuant to Section 15(i) of this Warrant and any pre-funded warrants issued pursuant to the Securities Purchase Agreement dated
March 26, 2019 between the Company and certain Investors, in each case provided that such issuance is pursuant to the terms of the applicable option or convertible security, (e) shares of Common Stock or rights, warrants or options to
purchase Common Stock issued to banks, equipment lessors or other financial institutions, real property lessors, or to other persons engaged in the business of making loans, pursuant to a debt financing, equipment leasing or real property leasing
transaction approved by the Board of Directors, or (f) shares of Common Stock or rights, warrants or options to purchase Common Stock issued in connection with sponsored research, collaboration, technology license, development, marketing or
other similar agreements or strategic partnerships approved by the Board of Directors. 
 (b)    Stock Dividends and
Splits. If the Company, at any time while this Warrant is outstanding, (i) pays a stock dividend on its Common Stock or otherwise makes a distribution on any class of capital stock issued and outstanding on the Original Issue Date and in
accordance with the terms of such stock on the Original Issue Date or as amended, that is payable in shares of Common Stock, (ii) subdivides its outstanding shares of Common Stock into a larger number of shares of Common Stock,
(iii) combines its outstanding shares of Common Stock into a smaller number of shares of Common Stock or (iv) issues by reclassification of shares of capital stock any additional shares of Common Stock of the Company, then in each such
case the number of Warrant Shares then underlying this Warrant shall be divided by a fraction, the numerator of which shall be the number of shares of Common Stock outstanding immediately before such event and the denominator of which shall be the
number of shares of Common Stock outstanding immediately after such event. Any adjustment made pursuant to clause (i) of this paragraph shall become effective immediately after the record date for the determination of stockholders entitled to
receive such dividend or distribution, provided, however, that if such record date shall have been fixed and such dividend is not fully paid on the date fixed therefor, the number of Warrant Shares shall be recomputed accordingly as of the close of
business on such record date and thereafter the Warrant Shares shall be adjusted pursuant to this paragraph as of the time of actual payment of such dividends. Any adjustment pursuant to clause (ii) or (iii) of this paragraph shall become
effective immediately after the effective date of such subdivision or combination. 
 (c)    Pro Rata
Distributions. If the Company, at any time while this Warrant is outstanding, distributes to all holders of Common Stock for no consideration (i) evidences of its indebtedness, (ii) any security (other than a distribution of Common
Stock covered by the preceding paragraph), (iii) rights or warrants to subscribe for or purchase any security, or (iv) cash or any other asset (in each case, “Distributed Property”), then, upon any exercise of this Warrant that
occurs after the record date fixed for determination of stockholders entitled to receive such distribution, the Holder shall be entitled to receive, in addition to the Warrant Shares otherwise issuable upon such exercise (if applicable), the
Distributed Property that such Holder would have been entitled to receive in respect of such number of Warrant Shares had the Holder been the record holder of such Warrant Shares immediately prior to such record date without regard to any limitation
on exercise contained therein. 
 (d)    Fundamental Transactions. If, at any time while this Warrant is
outstanding (i) the Company effects any merger or consolidation of the Company with or into another Person, in which the Company is not the surviving entity or the stockholders of the Company immediately prior to such merger or consolidation do
not own, directly or indirectly, at least 50% of the voting power of the surviving entity immediately after such merger or consolidation, (ii) the Company effects any sale to another Person of all or substantially all of its assets in one
transaction or a series of related transactions, (iii) pursuant to any tender 

  
 4 

 
offer or exchange offer (whether by the Company or another Person), holders of capital stock who tender shares representing more than 50% of the voting power of the capital stock of the Company
and the Company or such other Person, as applicable, accepts such tender for payment, (iv) the Company consummates a stock purchase agreement or other business combination (including, without limitation, a reorganization, recapitalization, spin-off or scheme of arrangement) with another Person whereby such other Person acquires more than the 50% of the voting power of the capital stock of the Company (except for any such transaction in which the
stockholders of the Company immediately prior to such transaction maintain, in substantially the same proportions, the voting power of such Person immediately after the transaction) or (v) the Company effects any reclassification of the Common
Stock or any compulsory share exchange pursuant to which the Common Stock is effectively converted into or exchanged for other securities, cash or property (other than as a result of a subdivision or combination of shares of Common Stock covered by
Section 9(b) above) (in any such case, a “Fundamental Transaction”), then following such Fundamental Transaction the Holder shall have the right to receive, upon exercise of this Warrant, the same amount
and kind of securities, cash or property as it would have been entitled to receive upon the occurrence of such Fundamental Transaction if it had been, immediately prior to such Fundamental Transaction, the holder of the number of Warrant Shares then
issuable upon exercise in full of this Warrant without regard to any limitations on exercise contained herein (the “Alternate Consideration”). The Company shall not effect any Fundamental Transaction in which the Company is not the
surviving entity or the Alternate Consideration includes securities of another Person unless (i) the Alternate Consideration is solely cash and the Company provides for the simultaneous “cashless exercise” of this Warrant pursuant to
Section 10 below or (ii) prior to or simultaneously with the consummation thereof, any successor to the Company, surviving entity or other Person (including any purchaser of assets of the Company) shall assume the obligation to deliver to
the Holder, such Alternate Consideration as, in accordance with the foregoing provisions, the Holder may be entitled to receive, and the other obligations under this Warrant. The provisions of this paragraph (d) shall similarly apply to
subsequent transactions analogous of a Fundamental Transaction type. 
 (e)    Calculations. All calculations
under this Section 9 shall be made to the nearest share. 
 (f)    Notice of
Adjustments. Upon the occurrence of each adjustment pursuant to this Section 9, the Company at its expense will, at the written request of the Holder, promptly compute such adjustment, in good faith, in accordance with
the terms of this Warrant and prepare a certificate setting forth such adjustment, including a statement of the adjusted number or type of Warrant Shares or other securities issuable upon exercise of this Warrant (as applicable), describing the
transactions giving rise to such adjustments and showing in detail the facts upon which such adjustment is based. Upon written request, the Company will promptly deliver a copy of each such certificate to the Holder and to the Company’s
transfer agent. 
 (g)    Notice of Corporate Events. If, while this Warrant is outstanding, the Company
(i) declares a dividend or any other distribution of cash, securities or other property in respect of its Common Stock, including, without limitation, any granting of rights or warrants to subscribe for or purchase any capital stock of the
Company or any subsidiary, (ii) authorizes or approves, enters into any agreement contemplating or solicits stockholder approval for any Fundamental Transaction or (iii) authorizes the voluntary dissolution, liquidation or winding up of
the affairs of the Company, then, except if such notice and the contents thereof shall be deemed to constitute material non-public information, the Company shall deliver to the Holder a notice of such
transaction at least ten (10) days prior to the applicable record or effective date on which a Person would need to hold Common Stock in order to participate in or vote with respect to such transaction; provided, however, that the
failure to deliver such notice or any defect therein shall not affect the validity of the corporate action required to be described in such notice. In addition, if while this Warrant is outstanding, the Company authorizes or approves, enters into
any agreement contemplating or solicits stockholder approval for any Fundamental Transaction contemplated by Section 9(d), other than a Fundamental Transaction under clause (iii) of
Section 9(d), the Company shall deliver to the Holder a notice of such Fundamental Transaction at least thirty (30) days prior to the date such Fundamental Transaction is consummated. Holder agrees to maintain any
information disclosed pursuant to this Section 9(g) in confidence until such information is publicly available, and shall comply with applicable law with respect to trading in the Company’s securities following receipt
any such information. 
 10.    Payment of Exercise Price. Notwithstanding anything contained herein to the contrary, the Holder
may, in its sole discretion, satisfy its obligation to pay the Exercise Price through a “cashless exercise,” in which event the Company shall issue to the Holder the number of Warrant Shares determined as follows: 

X = Y [(A-B)/A] 

where: 
 “X” equals
the number of Warrant Shares to be issued to the Holder; 

  
 5 

 “Y” equals the total number of Warrant Shares with respect to which this Warrant
is then being exercised; 
 “A” equals the average of the Closing Sale Prices of the shares of Common Stock (as reported by
Bloomberg Financial Markets) for the five (5) consecutive Trading Days ending on the date immediately preceding the Exercise Date; and 

“B” equals the Exercise Price then in effect for the applicable Warrant Shares at the time of such exercise. 

For purposes of Rule 144 promulgated under the Securities Act, it is intended, understood and acknowledged that the Warrant Shares issued in a “cashless
exercise” transaction shall be deemed to have been acquired by the Holder, and the holding period for the Warrant Shares shall be deemed to have commenced, on the date this Warrant was originally issued (provided that the Commission continues
to take the position that such treatment is proper at the time of such exercise). Except as set forth in Section 5(b) (Buy-In remedy) and Section 12 (payment of cash in lieu of fractional shares), in
no event will the exercise of this Warrant be settled in cash. 
 11.    Limitations on Exercise. 

(a)    Notwithstanding anything to the contrary contained herein, the number of Warrant Shares that may be acquired by the
Holder upon any exercise of this Warrant (or otherwise in respect hereof) shall be limited to the extent necessary to ensure that, following such exercise (or other issuance), the total number of shares of Common Stock then beneficially owned by the
Holder and its Affiliates and any other Persons whose beneficial ownership of Common Stock would be aggregated with the Holder’s for purposes of Section 13(d) of the Exchange Act, does not exceed 9.99% of the total number of then issued
and outstanding shares of Common Stock (including for such purpose the shares of Common Stock issuable upon such exercise), it being acknowledged by the Holder that the Company is not representing to such Holder that such calculation is in
compliance with Section 13(d) of the Exchange Act and such Holder is solely responsible for any schedules required to be filed in accordance therewith. To the extent that the limitation contained in this Section 11(a)
applies, the determination of whether this Warrant is exercisable (in relation to other securities owned by such Holder) and of which a portion of this Warrant is exercisable shall be in the sole discretion of the Holder, and the submission of a
Notice of Exercise shall be deemed to be the Holder’s determination of whether this Warrant is exercisable (in relation to other securities owned by such Holder) and of which portion of this Warrant is exercisable, in each case subject to such
aggregate percentage limitation, and the Company shall have no obligation to verify or confirm the accuracy of such determination. In addition, a determination under this Section 11(a) as to any group status shall be
determined in accordance with Section 13(d) of the Exchange Act and the rules and regulations promulgated thereunder. For purposes of this Section 11(a), in determining the number of outstanding shares of Common Stock,
the Holder may rely on the number of outstanding shares of Common Stock as reflected in (x) the Company’s most recent Form 10-Q or Form 10-K, as the case may
be, (y) a more recent public announcement by the Company or (z) any other notice by the Company or the Transfer Agent setting forth the number of shares of Common Stock outstanding. Upon the written request of the Holder, the Company
shall, within three (3) Trading Days, confirm orally and in writing to such Holder the number of shares of Common Stock then outstanding. By written notice to the Company, which will not be effective until the sixty-first (61st) day after such notice is delivered to the Company, the Holder may waive the provisions of this Section 11(a) or increase the beneficial ownership limitation to such
percentage of the number of shares of the Common Stock outstanding immediately after giving effect to the issuance of shares of Common Stock upon exercise of this Warrant as the Holder shall determine, in its sole discretion, subject to
Section 11(b), and the provisions of this Section 11(a) shall continue to apply. Upon such a change by a Holder of the beneficial ownership limitation from such 9.99% limitation to such other
percentage limitation, the beneficial ownership limitation may not be further waived or increased by such Holder without first providing the minimum notice required by this Section 11(a). Notwithstanding the foregoing, at
any time following notice of a Fundamental Transaction under Section 9(f)(ii) with respect to a Section 9(c)(iii) Fundamental Transaction, the Holder may waive and/or change the beneficial
ownership limitation effective immediately upon written notice to the Company and may reinstitute a beneficial ownership limitation at any time thereafter effective immediately upon written notice to the Company. 

(b)    Notwithstanding anything to the contrary contained herein, including Section 11(a), the
Company shall not effect any exercise of this Warrant, and the Holder shall not be entitled to exercise this Warrant for a number of Warrant Shares in excess of that number of Warrant Shares which, upon giving effect to such exercise, would cause
(i) the aggregate number of shares of Common Stock beneficially owned by the Holder and its Affiliates and any other Persons whose beneficial ownership of Common Stock would be aggregated with the Holder’s for purposes of
Section 13(d) of the Exchange Act, to exceed 19.99% of the total number of issued and outstanding shares of Common Stock of the Company following such exercise, or (ii) the combined voting power of the securities of the Company
beneficially owned by the Holder and its Affiliates and any other Persons whose beneficial ownership of Common Stock would be aggregated with the Holder’s for purposes of Section 13(d) of the Exchange Act to exceed 19.99% of the combined
voting power of all of the securities of the Company then outstanding 

  
 6 

 
following such exercise. For purposes of this Section 11(b), the aggregate number of shares of Common Stock or voting securities beneficially owned by the Holder and its
Affiliates and any other Persons whose beneficial ownership of Common Stock would be aggregated with the Holder’s for purposes of Section 13(d) of the Exchange Act shall include the shares of Common Stock issuable upon the exercise of this
Warrant with respect to which such determination is being made, but shall exclude the number of shares of Common Stock which would be issuable upon (x) exercise of the remaining unexercised and
non-cancelled portion of this Warrant by the Holder and (y) exercise or conversion of the unexercised, non-converted or
non-cancelled portion of any other securities of the Company that do not have voting power (including without limitation any securities of the Company which would entitle the holder thereof to acquire at any
time Common Stock, including without limitation any debt, preferred stock, right, option, warrant or other instrument that is at any time convertible into or exercisable or exchangeable for, or otherwise entitles the holder thereof to receive,
Common Stock), is subject to a limitation on conversion or exercise analogous to the limitation contained herein and is beneficially owned by the Holder or any of its Affiliates and other Persons whose beneficial ownership of Common Stock would be
aggregated with the Holder’s for purposes of Section 13(d) of the Exchange Act. 
 (c)    This
Section 11 shall not restrict the number of shares of Common Stock which a Holder may receive or beneficially own in order to determine the amount of securities or other consideration that such Holder may receive in the
event of a Fundamental Transaction as contemplated in Section 9 of this Warrant. 
 12.    No Fractional
Shares. No fractional Warrant Shares will be issued in connection with any exercise of this Warrant. In lieu of any fractional shares that would otherwise be issuable, the number of Warrant Shares to be issued shall be rounded down to the next
whole number and the Company shall pay the Holder in cash the fair market value (based on the Closing Sale Price) for any such fractional shares. 

13.    Notices. Any and all notices or other communications or deliveries hereunder (including, without limitation, any Exercise
Notice) shall be in writing and shall be deemed given and effective on the earliest of (i) the date of transmission, if such notice or communication is delivered via facsimile or confirmed e-mail at the
facsimile number or e-mail address specified below prior to 5:30 P.M., New York City time, on a Trading Day, (ii) the next Trading Day after the date of transmission, if such notice or communication is
delivered via facsimile or confirmed e-mail at the facsimile number or e-mail address specified below on a day that is not a Trading Day or later than 5:30 P.M., New
York City time, on any Trading Day, (iii) the Trading Day following the date of mailing, if sent by nationally recognized overnight courier service specifying next business day delivery, or (iv) upon actual receipt by the Person to whom
such notice is required to be given, if by hand delivery. 
 14.    Warrant Agent. The Company shall initially serve as warrant
agent under this Warrant. Upon thirty (30) days’ notice to the Holder, the Company may appoint a new warrant agent. Any corporation into which the Company or any new warrant agent may be merged or any corporation resulting from any
consolidation to which the Company or any new warrant agent shall be a party or any corporation to which the Company or any new warrant agent transfers substantially all of its corporate trust or shareholders services business shall be a successor
warrant agent under this Warrant without any further act. Any such successor warrant agent shall promptly cause notice of its succession as warrant agent to be mailed (by first class mail, postage prepaid) to the Holder at the Holder’s last
address as shown on the Warrant Register. 
 15.    Miscellaneous. 

(a)    No Rights as a Stockholder. The Holder, solely in such Person’s capacity as a holder of this Warrant,
shall not be entitled to vote or receive dividends or be deemed the holder of share capital of the Company for any purpose, nor shall anything contained in this Warrant be construed to confer upon the Holder, solely in such Person’s capacity as
the Holder of this Warrant, any of the rights of a stockholder of the Company or any right to vote, give or withhold consent to any corporate action (whether any reorganization, issue of stock, reclassification of stock, consolidation, merger,
amalgamation, conveyance or otherwise), receive notice of meetings, receive dividends or subscription rights, or otherwise, prior to the issuance to the Holder of the Warrant Shares which such Person is then entitled to receive upon the due exercise
of this Warrant. In addition, nothing contained in this Warrant shall be construed as imposing any liabilities on the Holder to purchase any securities (upon exercise of this Warrant or otherwise) or as a stockholder of the Company, whether such
liabilities are asserted by the Company or by creditors of the Company. 
 (b)    Authorized Shares. 

(i) Except and to the extent as waived or consented to by the Holder, the Company shall not by any action, including, without limitation,
amending its certificate or articles of incorporation or through any reorganization, transfer of assets, 

  
 7 

 
consolidation, merger, dissolution, issue or sale of securities or any other voluntary action, avoid or seek to avoid the observance or performance of any of the terms of this Warrant, but will
at all times in good faith assist in the carrying out of all such terms and in the taking of all such actions as may be necessary or appropriate to protect the rights of Holder as set forth in this Warrant against impairment. Without limiting the
generality of the foregoing, the Company will (a) not increase the par value of any Warrant Shares above the amount payable therefor upon such exercise immediately prior to such increase in par value, (b) take all such action as may be
necessary or appropriate in order that the Company may validly and legally issue fully paid and nonassessable Warrant Shares upon the exercise of this Warrant, and (c) use commercially reasonable efforts to obtain all such authorizations,
exemptions or consents from any public regulatory body having jurisdiction thereof as may be necessary to enable the Company to perform its obligations under this Warrant. 

(ii) Before taking any action which would result in an adjustment in the number of Warrant Shares for which this Warrant is exercisable or in
the Exercise Price, the Company shall obtain all such authorizations or exemptions thereof, or consents thereto, as may be necessary from any public regulatory body or bodies having jurisdiction thereof. 

(c)    Successors and Assigns. Subject to the restrictions on transfer set forth in this Warrant and the
restrictions on transfer set forth in this Warrant and compliance with applicable securities laws, this Warrant may be assigned by the Holder. This Warrant may not be assigned by the Company without the written consent of the Holder except to a
successor in the event of a Fundamental Transaction. This Warrant shall be binding on and inure to the benefit of the Company and the Holder and their respective successors and assigns. Subject to the preceding sentence, nothing in this Warrant
shall be construed to give to any Person other than the Company and the Holder any legal or equitable right, remedy or cause of action under this Warrant. This Warrant may be amended only in writing signed by the Company and the Holder, or their
successors and assigns. 
 (d)    Amendment and Waiver. Except as otherwise provided herein, the provisions of
the Warrants may be amended and the Company may take any action herein prohibited, or omit to perform any act herein required to be performed by it, only if the Company has obtained the written consent of the Holders of Warrants representing no less
than a majority of the Warrant Shares obtainable upon exercise of the Warrants then outstanding. 

(e)    Acceptance. Receipt of this Warrant by the Holder shall constitute acceptance of and agreement to all of the
terms and conditions contained herein. 
 (f)    Governing Law; Jurisdiction. ALL QUESTIONS CONCERNING THE
CONSTRUCTION, VALIDITY, ENFORCEMENT AND INTERPRETATION OF THIS WARRANT SHALL BE GOVERNED BY AND CONSTRUED AND ENFORCED IN ACCORDANCE WITH THE LAWS OF THE STATE OF NEW YORK WITHOUT REGARD TO THE PRINCIPLES OF CONFLICTS OF LAW THEREOF. EACH OF THE
COMPANY AND THE HOLDER HEREBY IRREVOCABLY SUBMITS TO THE EXCLUSIVE JURISDICTION OF THE STATE AND FEDERAL COURTS SITTING IN THE CITY OF NEW YORK, BOROUGH OF MANHATTAN, FOR THE ADJUDICATION OF ANY DISPUTE HEREUNDER OR IN CONNECTION HEREWITH OR WITH
ANY TRANSACTION CONTEMPLATED HEREBY OR DISCUSSED HEREIN (INCLUDING WITH RESPECT TO THE ENFORCEMENT OF ANY OF THE TRANSACTION DOCUMENTS), AND HEREBY IRREVOCABLY WAIVES, AND AGREES NOT TO ASSERT IN ANY SUIT, ACTION OR PROCEEDING, ANY CLAIM THAT IT IS
NOT PERSONALLY SUBJECT TO THE JURISDICTION OF ANY SUCH COURT. EACH OF THE COMPANY AND THE HOLDER HEREBY IRREVOCABLY WAIVES PERSONAL SERVICE OF PROCESS AND CONSENTS TO PROCESS BEING SERVED IN ANY SUCH SUIT, ACTION OR PROCEEDING BY MAILING A COPY
THEREOF VIA REGISTERED OR CERTIFIED MAIL OR OVERNIGHT DELIVERY (WITH EVIDENCE OF DELIVERY) TO SUCH PERSON AT THE ADDRESS IN EFFECT FOR NOTICES TO IT AND AGREES THAT SUCH SERVICE SHALL CONSTITUTE GOOD AND SUFFICIENT SERVICE OF PROCESS AND NOTICE
THEREOF. NOTHING CONTAINED HEREIN SHALL BE DEEMED TO LIMIT IN ANY WAY ANY RIGHT TO SERVE PROCESS IN ANY MANNER PERMITTED BY LAW. EACH OF THE COMPANY AND THE HOLDER HEREBY WAIVES ALL RIGHTS TO A TRIAL BY JURY. 

(g)    Headings. The headings herein are for convenience only, do not constitute a part of this Warrant and shall
not be deemed to limit or affect any of the provisions hereof. 
 (h)    Severability. In case any one or more of
the provisions of this Warrant shall be invalid or unenforceable in any respect, the validity and enforceability of the remaining terms and provisions of this Warrant shall not in any way be affected or impaired thereby, and the Company and the
Holder will attempt in good faith to agree upon a valid and enforceable provision which shall be a commercially reasonable substitute therefor, and upon so agreeing, shall incorporate such substitute provision in this Warrant. 

  
 8 

 (i)    Pre-Funded Warrants in
lieu of Common Stock. Notwithstanding anything to the contrary in this Warrant, the Holder may choose, in lieu of receiving Warrant Shares upon exercise of this Warrant, to receive a pre-funded warrant in
the form attached hereto as EXHIBIT A (the “Pre-Funded Warrant”) to purchase an identical number of shares of common stock it would have receive upon the exercise of this
Warrant for shares of common stock, provided, however that the Exercise Price shall instead be the Exercise Price less $0.0001 per share, and the resulting issued Pre-Funded Warrant shall have an
exercise price of $0.0001 per share. 
 [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK] 

  
 9 

 IN WITNESS WHEREOF, the Company has caused this Warrant to be duly executed by its
authorized officer as of the date first indicated above. 
  

			
	SYNDAX PHARMACEUTICALS, INC.
		
	By:	 	  

	Name:	 	Luke J. Albrecht
	Title:	 	Vice President, General Counsel and Secretary

  
 10 

 SCHEDULE 1 

FORM OF EXERCISE NOTICE 
 [To be
executed by the Holder to purchase shares of Common Stock under the Warrant] 
 Ladies and Gentlemen: 

 

	(1)	 The undersigned is the Holder of Warrant No.          (the
“Warrant”) issued by Syndax Therapeutics, Inc., a Delaware corporation (the “Company”). Capitalized terms used herein and not otherwise defined herein have the respective meanings set forth in the Warrant.

  

	(2)	 The undersigned hereby exercises its right to purchase Warrant Shares pursuant to the Warrant.

  

	(3)	 The Holder intends that payment of the Exercise Price shall be made as (check one): 

 

	 	☐	 Cash Exercise 

  

	 	☐	 “Cashless Exercise” under Section 10 of the Warrant 

 

	(4)	 If the Holder has elected a Cash Exercise, the Holder shall pay the sum of
$                in immediately available funds to the Company in accordance with the terms of the Warrant. 

 

	(5)	 Except as set forth in paragraph (6), pursuant to this Exercise Notice, the Company shall deliver to the Holder
Warrant Shares determined in accordance with the terms of the Warrant. 

  

	(6)	 The Holder hereby elects to receive a Pre-Funded Warrant (in the form
attached hereto as EXHIBIT A) to purchase an identical number of shares of common stock that it would receive if it had exercised this Warrant for shares of Common Stock in lieu of receiving the Warrant Shares in
accordance with this Warrant.   ☐ 

  

	(7)	 By its delivery of this Exercise Notice, the undersigned represents and warrants to the Company that in giving
effect to the exercise evidenced hereby the Holder will not beneficially own in excess of the number of shares of Common Stock (as determined in accordance with Section 13(d) of the Securities Exchange Act of 1934, as amended) permitted to be
owned under Section 11(a) or Section 11(b), as applicable, of the Warrant to which this notice relates. 

  

			
	Dated:	 	  

		
	Name of Holder:	 	  

		
	By:	 	  

	Name:	 	  

	Title:	 	  

 (Signature must conform in all respects to name of Holder as specified on the face of the Warrant) 

 EXHIBIT A 

FORM OF PRE-FUNDED
WARRANT

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