Document:

EX-10.10

 Exhibit 10.10 

VERSARTIS, INC. 

INDEMNIFICATION AGREEMENT 

THIS INDEMNIFICATION AGREEMENT (“Agreement”) is
effective as of                      , 2014, by and between VERSARTIS, INC., a Delaware
corporation (the “Company”), and                  (“Indemnitee”). 

A. The Company desires to attract and retain the services of highly qualified individuals, such as Indemnitee, to serve the Company and its
related entities. 
 B. In order to induce Indemnitee to continue to provide services to the Company, the Company wishes to provide for the
indemnification of, and the advancement of expenses to, Indemnitee to the maximum extent permitted by law. 
 C. The Company and Indemnitee
recognize the continued difficulty in obtaining liability insurance for the Company’s directors, officers, employees, agents and fiduciaries, the significant increases in the cost of such insurance and the general reductions in the coverage of
such insurance. 
 D. Indemnitee does not regard the protection available under the Company’s Bylaws and insurance as adequate in the
present circumstances, and may not be willing to serve as an officer or director without adequate protection, and the Company desires Indemnitee to serve in such capacity. 

E. The Company and Indemnitee further recognize the substantial increase in corporate litigation in general, subjecting directors, officers,
employees, agents and fiduciaries to expensive litigation risks at the same time as the availability and coverage of liability insurance has been severely limited. 

F. In view of the considerations set forth above, the Company desires that Indemnitee shall be indemnified and advanced expenses by the
Company as set forth in this Agreement. 
 G. Indemnitee may have certain rights to indemnification and/or insurance provided by one or more
other entities and/or organizations, which Indemnitee and the Company intend to be secondary to the primary obligation of the Company to indemnify Indemnitee as provided herein, with the Company’s acknowledgement and agreement to the foregoing
being a material condition to Indemnitee’s willingness to serve on the Board of Directors of the Company. 
 The parties agree as follows: 

1. DEFINITIONS. 

(a) “Change in Control” means, and will be deemed to have occurred if, on or after the date of this Agreement,
(i) any “person” (as such term is used in Sections 13(d) and 14(d) of the Securities Exchange Act of 1934, as amended), other than a trustee or other fiduciary holding securities under an employee benefit plan of the Company
acting in such capacity or a corporation owned directly or indirectly by the stockholders of the Company in substantially the same proportions as their ownership of stock of the Company, becomes the “beneficial owner” (as defined in
Rule 13d-3 under said Act), directly or indirectly, of securities of the Company representing more than 50% of the total voting power represented by the Company’s then outstanding Voting Securities (as defined below), (ii) during any
period of two consecutive years, individuals who at the beginning of such period constitute the Board of Directors of the Company and any new director whose election by the Board of Directors or nomination

 
for election by the Company’s stockholders was approved by a vote of at least two-thirds of the directors then still in office who either were directors at the beginning of the period or
whose election or nomination for election was previously so approved, cease for any reason to constitute a majority thereof, or (iii) the stockholders of the Company approve a merger or consolidation of the Company with any other corporation
other than a merger or consolidation that would result in the Voting Securities of the Company outstanding immediately prior thereto continuing to represent (either by remaining outstanding or by being converted into Voting Securities of the
surviving entity) at least 80% of the total voting power represented by the Voting Securities of the Company or such surviving entity outstanding immediately after such merger or consolidation, or the stockholders of the Company approve a plan of
complete liquidation of the Company or an agreement for the sale or disposition by the Company of (in one transaction or a series of related transactions) all or substantially all of the Company’s assets. 

(b) “Claim” means, with respect to a Covered Event (as defined below), any threatened, pending or completed
action, suit, proceeding or alternative dispute resolution mechanism, or any hearing, inquiry or investigation that Indemnitee in good faith believes might lead to the institution of any such action, suit, proceeding or alternative dispute
resolution mechanism, whether civil, criminal, administrative, investigative or other and whether brought in the right of or by the Company or otherwise. 

(c) References to the “Company” include, in addition to Versartis, Inc., any constituent corporation (including
any constituent of a constituent) absorbed in a consolidation or merger to which Versartis, Inc. (or any of its wholly owned subsidiaries) is a party, that, if its separate existence had continued, would have had power and authority to indemnify its
directors, officers, employees, agents or fiduciaries, so that if Indemnitee is or was a director, officer, employee, agent or fiduciary of such constituent corporation, or is or was serving at the request of such constituent corporation as a
director, officer, employee, agent or fiduciary of another corporation, partnership, joint venture, employee benefit plan, trust or other enterprise, Indemnitee will stand in the same position under the provisions of this Agreement with respect to
the resulting or surviving corporation as Indemnitee would have with respect to such constituent corporation if its separate existence had continued. 

(d) “Covered Event” means any event or occurrence (i) related to the fact that Indemnitee is or was a
director, officer, employee, agent or fiduciary of the Company, or any subsidiary of the Company or (ii) related to the fact that Indemnitee is or was serving at the request of the Company as a director, officer, employee, agent or fiduciary of
another corporation, partnership, joint venture, trust or other enterprise, or by reason of any action or inaction on the part of Indemnitee while serving in such capacity. 

(e) “Expenses” means any and all expenses (including attorneys’ fees and all other costs, expenses and
obligations incurred in connection with investigating, defending, being a witness in or participating in (including on appeal), or preparing to defend, to be a witness in or to participate in, any action, suit, proceeding, alternative dispute
resolution mechanism, hearing, inquiry or investigation), judgments, fines, penalties and amounts paid in settlement (if such settlement is approved in advance by the Company, which approval will not be unreasonably withheld), actually and
reasonably incurred, of any Claim and any federal, state, local or foreign taxes imposed on the Indemnitee as a result of the actual or deemed receipt of any payments under this Agreement. 

(f) “Expense Advance” means a payment to Indemnitee pursuant to Section 3 of Expenses in advance of the
settlement of or final judgment in any action, suit, proceeding or alternative dispute resolution mechanism, hearing, inquiry or investigation that constitutes a Claim. 

  
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 (g) “Independent Legal Counsel” means an attorney or firm of
attorneys, selected in accordance with the provisions of Section 2(d) hereof, who will not have otherwise performed services for the Company or Indemnitee within the last three years (other than with respect to matters concerning the rights of
Indemnitee under this Agreement, or of other indemnitees under similar indemnity agreements). 
 (h) References to “other
enterprises” include employee benefit plans; references to “fines” include any excise taxes assessed on Indemnitee with respect to an employee benefit plan; and references to “serving at the request of
the Company” include any service as a director, officer, employee, agent or fiduciary of the Company, which role imposes duties on, or involves services by, such director, officer, employee, agent or fiduciary with respect to an
employee benefit plan, its participants or its beneficiaries; and if Indemnitee acted in good faith and in a manner Indemnitee reasonably believed to be in the interest of the participants and beneficiaries of an employee benefit plan, Indemnitee
will be deemed to have acted in a manner “not opposed to the best interests of the Company” as referred to in this Agreement. 

(i) “Reviewing Party” means, subject to the provisions of Section 2(d), any person or body appointed by
the Board of Directors in accordance with applicable law to review the Company’s obligations hereunder and under applicable law, which may include (i) the directors who are not parties to the action, suit or proceeding in question
(“Disinterested Directors”), even if less than a quorum, (ii) a committee of Disinterested Directors designated by a vote of the majority of the Disinterested Directors, even if less than a quorum, (iii), by Independent
Legal Counsel, if there are no such Disinterested Directors, or if such Disinterested Directors so direct or (iv) by the stockholders. 

(j) “Section” refers to a section of this Agreement unless otherwise indicated. 

(k) “Voting Securities” means any securities of the Company that vote generally in the election of directors.

 2. INDEMNIFICATION. 

(a) Indemnification of Expenses. Subject to the provisions of Section 2(b) below, the Company shall indemnify Indemnitee for
Expenses to the fullest extent permitted by law if Indemnitee was or is or becomes a party to or witness or other participant in, or is threatened to be made a party to or witness or other participant in, any Claim (whether by reason of or arising
in part out of a Covered Event), including all interest, assessments and other charges paid or payable in connection with or in respect of such Expenses. 

(b) Review of Indemnification Obligations. Notwithstanding the foregoing, upon written request for indemnification pursuant to
Section 4(b), a determination with respect to Indemnitee’s entitlement thereto shall be determined by a Reviewing Party selected pursuant to Section 2(d). In the event any Reviewing Party will have determined (in a written opinion, in
any case in which Independent Legal Counsel is the Reviewing Party) that Indemnitee is not entitled to be indemnified hereunder under applicable law, (i) the Company shall have no further obligation under Section 2(a) to make any payments
to Indemnitee not made prior to such determination by such Reviewing Party, and (ii) the Company shall be entitled to be reimbursed by Indemnitee (who hereby agrees to reimburse the Company) for all Expenses theretofore paid in indemnifying
Indemnitee; provided, however, that if Indemnitee has commenced or thereafter commences legal proceedings in a court of competent jurisdiction to secure a determination that Indemnitee is entitled to be indemnified hereunder under applicable
law, any determination made by any Reviewing Party that Indemnitee is not entitled to be indemnified hereunder under applicable law will not be binding and Indemnitee shall not be required to reimburse the Company for any Expenses theretofore paid
in indemnifying Indemnitee until a final judicial determination is made with respect thereto (as to which all rights of appeal therefrom have been exhausted or lapsed). Indemnitee’s obligation to reimburse the Company for any Expenses will be
unsecured and no interest will be charged thereon. 

  
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 (c) Indemnitee Rights on Unfavorable Determination; Binding Effect. If any Reviewing Party
determines that Indemnitee is not entitled to be indemnified hereunder in whole or in part under applicable law, Indemnitee shall have the right to commence litigation seeking an initial determination by the court or challenging any such
determination by such Reviewing Party or any aspect thereof, including the legal or factual bases therefor, and, subject to the provisions of Section 15, the Company hereby consents to service of process and to appear in any such proceeding.
Absent such litigation, any determination by any Reviewing Party will be conclusive and binding on the Company and Indemnitee. 
 (d)
Selection of Reviewing Party; Change in Control. If there has not been a Change in Control, any Reviewing Party will be selected by the Board of Directors and approved by the Indemnitee (which approval will not be unreasonably withheld). If the
Board chooses to utilize an Independent Legal Counsel as the Reviewing Party, the Independent Legal Counsel will be chosen by the Company and approved by the Indemnitee (which approval will not be unreasonably withheld). If there has been such a
Change in Control (other than a Change in Control that has been approved by a majority of the Company’s Board of Directors who were directors immediately prior to such Change in Control), any Reviewing Party with respect to all matters
thereafter arising concerning the rights of Indemnitee to indemnification of Expenses under this Agreement or any other agreement or under the Company’s certificate of incorporation or bylaws as now or hereafter in effect, or under any other
applicable law, if desired by Indemnitee, will be Independent Legal Counsel selected by Indemnitee and approved by the Company (which approval shall not be unreasonably withheld). Such counsel, among other things, will render its written opinion to
the Company and Indemnitee as to whether and to what extent Indemnitee would be entitled to be indemnified hereunder under applicable law and the Company agrees to abide by such opinion. The Company agrees to pay the reasonable fees of the
Independent Legal Counsel referred to above and to indemnify fully such counsel against any and all expenses (including attorneys’ fees), claims, liabilities and damages arising out of or relating to this Agreement or its engagement pursuant
hereto. Notwithstanding any other provision of this Agreement, the Company shall not be required to pay Expenses of more than one Independent Legal Counsel in connection with all matters concerning a single Indemnitee, and such Independent Legal
Counsel shall be the Independent Legal Counsel for any or all other Indemnitees unless (i) the Company otherwise determines or (ii) any Indemnitee shall provide a written statement setting forth in detail a reasonable objection to such
Independent Legal Counsel representing other Indemnitees. 
 (e) Mandatory Payment of Expenses. Notwithstanding any other provision
of this Agreement other than Section 10 hereof, to the extent that Indemnitee has been successful on the merits or otherwise, including, without limitation, the dismissal of an action without prejudice, in defense of any Claim, Company shall
indemnify Indemnitee against all Expenses incurred by Indemnitee in connection therewith. 
 3. EXPENSE
ADVANCES. 
 (a) Obligation to Make Expense Advances. The Company will make Expense Advances to Indemnitee upon
receipt of a written undertaking by or on behalf of the Indemnitee to repay such amounts if it is ultimately determined that the Indemnitee is not entitled to be indemnified therefor by the Company. 

(b) Form of Undertaking. Any written undertaking by the Indemnitee to repay any Expense Advances hereunder will be unsecured, and no
interest shall be charged thereon. 

  
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 4. PROCEDURES FOR INDEMNIFICATION
AND EXPENSE ADVANCES. 
 (a) Timing of Payments. All payments of Expenses (including
without limitation Expense Advances) by the Company to the Indemnitee pursuant to this Agreement will be made to the fullest extent permitted by law as soon as practicable after written demand by Indemnitee therefor is presented to the Company, but
in no event later than 30 days after such written demand by Indemnitee is presented to the Company, except in the case of Expense Advances, which will be made no later than 20 days after such written demand by Indemnitee is presented to the Company.

 (b) Notice/Cooperation by Indemnitee. Indemnitee shall, as a condition precedent to Indemnitee’s right to be indemnified or
Indemnitee’s right to receive Expense Advances under this Agreement, give the Company notice in writing as soon as practicable of any Claim made against Indemnitee for which indemnification will or could be sought under this Agreement. Notice
to the Company will be directed to the President or Chief Executive Officer of the Company at the address shown on the signature page of this Agreement (or such other address as the Company shall designate in writing to Indemnitee). In addition,
Indemnitee will give the Company such information and cooperation as it may reasonably require and as shall be within Indemnitee’s power. The failure by Indemnitee to timely notify the Company of any Claim will not relieve the Company from any
liability hereunder unless, and only to the extent that such failure results in forfeiture by the Company of substantial defenses, rights, or insurance coverage. 

(c) Timing of Indemnification Determination. The Company will use its reasonable best efforts to cause any determination by a
Reviewing Party to be made as promptly as practicable. If the Reviewing Party shall not have made a determination within 60 days after the later of (A) receipt by the Company of written notice from Indemnitee advising the Company of the final
disposition of the applicable Covered Event and (B) the selection of an Independent Counsel, if such determination is to be made by Independent Counsel, then Indemnitee shall be deemed to have satisfied the applicable standard of conduct absent
(i) a misstatement by Indemnitee of a material fact, or an omission of a material fact necessary to make Indemnitee’s statement not materially misleading, in connection with the request for indemnification, or (ii) a prohibition of
such indemnification under applicable law; provided, however, that such 60-day period may be extended for a reasonable time, not to exceed (1) an additional 30 days, if the person, persons or entity making such determination with respect
to entitlement to indemnification in good faith requires such additional time to obtain or evaluate documentation and/or information relating thereto or (2) an additional 75 days, if the Reviewing Party will be the stockholders of the Company.

 (d) No Presumptions; Burden of Proof. For purposes of this Agreement, the termination of any Claim by judgment, order, settlement
(whether with or without court approval) or conviction, or upon a plea of nolo contendere, or its equivalent, will not create a presumption that Indemnitee did not meet any particular standard of conduct or have any particular belief or that
a court has determined that indemnification is not permitted by this Agreement or applicable law. In addition, neither the failure of any Reviewing Party to have made a determination as to whether Indemnitee has met any particular standard of
conduct or had any particular belief, nor an actual determination by any Reviewing Party that Indemnitee has not met such standard of conduct or did not have such belief, prior to the commencement of legal proceedings by Indemnitee to secure a
judicial determination that Indemnitee should be indemnified under this Agreement or applicable law, shall be a defense to Indemnitee’s claim or create a presumption that Indemnitee has not met any particular standard of conduct or did not have
any particular belief. In connection with any determination by any Reviewing Party or otherwise as to whether the Indemnitee is entitled to be indemnified hereunder, the burden of proof will be on the Company to establish that Indemnitee is not so
entitled. 

  
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 (e) Notice to Insurers. If, at the time of the receipt by the Company of a notice of a
Claim pursuant to Section (b) hereof, the Company has liability insurance in effect that may cover such Claim, the Company shall give prompt notice of the commencement of such Claim to the insurers in accordance with the procedures set forth in
the respective policies. The Company shall thereafter take all necessary or desirable action to cause such insurers to pay, on behalf of the Indemnitee, all amounts payable as a result of such Claim in accordance with the terms of such policies;
provided, however, that nothing in this subsection (e) shall relieve the Company of its obligations hereunder (or allow the Company to delay in its performance of its obligations hereunder) to provide indemnification for or make any
Expense Advances with respect to the Expenses of any Claim, between the time that it so notifies its insurers and the time that its insurers actually pay any such amounts payable as a result of any such Claim to the Company. 

(f) Selection of Counsel. In the event the Company shall be obligated hereunder to provide indemnification for or make any Expense
Advances with respect to the Expenses of any Claim, the Company, if appropriate, shall be entitled to assume the defense of such Claim with counsel approved by Indemnitee (which approval shall not be unreasonably withheld) upon the delivery to
Indemnitee of written notice of the Company’s election to do so. After delivery of such notice, approval of such counsel by Indemnitee and the retention of such counsel by the Company, the Company will not be liable to Indemnitee under this
Agreement for any fees or expenses of separate counsel subsequently employed by or on behalf of Indemnitee with respect to the same Claim; provided, however, that (i) Indemnitee shall have the right to employ Indemnitee’s separate
counsel in any such Claim at Indemnitee’s expense and (ii) if (A) the employment of separate counsel by Indemnitee has been previously authorized by the Company, (B) Indemnitee shall have reasonably concluded that there may be a
conflict of interest between the Company and Indemnitee in the conduct of any such defense, or (C) the Company shall not continue to retain such counsel to defend such Claim, then the fees and expenses of Indemnitee’s separate counsel will
be Expenses for which Indemnitee may receive indemnification or Expense Advances hereunder. The Company shall not be liable to Indemnitee under this Agreement for any amounts paid in settlement of any threatened or pending Claim effected without the
Company’s prior written consent. The Company shall not, without the prior written consent of the Indemnitee, effect any settlement of any threatened or pending Claim which the Indemnitee is or could have been a party unless such settlement
solely involves the payment of money and includes a complete and unconditional release of the Indemnitee from all liability on any claims that are the subject matter of such Claim. Neither the Company nor Indemnitee shall unreasonably withhold its
consent to any proposed settlement; provided that Indemnitee may withhold consent to any settlement that does not provide a complete and unconditional release of Indemnitee. 

5. ADDITIONAL INDEMNIFICATION RIGHTS; NONEXCLUSIVITY. 

(a) Scope. The Company hereby agrees to indemnify the Indemnitee to the fullest extent permitted by law, notwithstanding that such
indemnification is not specifically authorized by the other provisions of this Agreement, the Company’s Certificate of Incorporation, the Company’s Bylaws or by statute. In the event of any change after the date of this Agreement in any
applicable law, statute or rule that expands the right of a Delaware corporation to indemnify a member of its board of directors or an officer, employee, agent or fiduciary, it is the intent of the parties hereto that Indemnitee shall enjoy by this
Agreement the greater benefits afforded by such change. In the event of any change in any applicable law, statute or rule that narrows the right of a Delaware corporation to indemnify a member of its board of directors or an officer, employee, agent
or fiduciary, such change, to the extent not otherwise required by such law, statute or rule to be applied to this Agreement, will have no effect on this Agreement or the parties’ rights and obligations hereunder except as set forth in
Section 10(a) hereof. 

  
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 (b) Nonexclusivity. The indemnification and the payment of Expense Advances provided by
this Agreement will be in addition to any rights to which Indemnitee may be entitled under the Company’s certificate of incorporation, its bylaws, any other agreement, any vote of stockholders or disinterested directors, the Delaware General
Corporation Law, or otherwise. The indemnification and the payment of Expense Advances provided under this Agreement will continue as to Indemnitee for any action taken or not taken while serving in an indemnified capacity even though subsequent
thereto Indemnitee may have ceased to serve in such capacity. 
 (c) Company Obligations Primary. The Company hereby acknowledges
that Indemnitee may have certain rights to indemnification, advancement of expenses and/or insurance provided by one or more other entities and/or organizations (collectively, the “Secondary Indemnitors”). The Company hereby
agrees that (i) it is the indemnitor of first resort (i.e., its obligations to Indemnitee are primary and any obligation of the Secondary Indemnitors to advance expenses or to provide indemnification for the same Expenses or liabilities
incurred by Indemnitee are secondary), (ii) it will be required to advance the full amount of Expenses incurred by Indemnitee and will be liable for the full amount of all Expenses, judgments, penalties, fines and amounts paid in settlement to
the extent legally permitted and as required by the Certificate of Incorporation or Bylaws of the Company (or any agreement between the Company and Indemnitee), without regard to any rights Indemnitee may have against the Secondary Indemnitors and
(iii) it irrevocably waives relinquishes and releases the Secondary Indemnitors from any and all claims against the Secondary Indemnitors for contribution, subrogation or any other recovery of any kind in respect thereof. The Company further
agrees that no advancement or payment by the Secondary Indemnitors on behalf of Indemnitee with respect to any claim for which Indemnitee has sought indemnification from the Company will affect the foregoing and the Secondary Indemnitors will have a
right of contribution and/or be subrogated to the extent of such advancement or payment to all of the rights of recovery of Indemnitee against the Company. The Company and Indemnitee agree that the Secondary Indemnitors are express third party
beneficiaries of the terms hereof. 
 6. NO DUPLICATION OF PAYMENTS.
Subject to Section 5(c) above, the Company will not be liable under this Agreement to make any payment in connection with any Claim made against Indemnitee to the extent Indemnitee has otherwise actually received payment (under any insurance
policy, provision of the Company’s certificate of incorporation, bylaws or otherwise) of the amounts otherwise payable under this Agreement. 

7. PARTIAL INDEMNIFICATION. If Indemnitee is entitled under any provision of this Agreement to
indemnification by the Company for some or a portion of Expenses incurred in connection with any Claim, but not, however, for all of the total amount thereof, the Company will indemnify Indemnitee for the portion of such Expenses to which Indemnitee
is entitled. 
 8. MUTUAL ACKNOWLEDGMENT. Both the Company and Indemnitee acknowledge that in certain
instances, federal law or applicable public policy may prohibit the Company from indemnifying its directors, officers, employees, agents or fiduciaries under this Agreement or otherwise. Indemnitee understands and acknowledges that the Company has
undertaken or may be required in the future to undertake with the Securities and Exchange Commission to submit the question of indemnification to a court in certain circumstances for a determination of the Company’s right under public policy to
indemnify Indemnitee. 
 9. LIABILITY INSURANCE. The Company shall obtain and maintain during the term
of this Agreement liability insurance applicable to directors, officers or fiduciaries in an amount determined by the Company’s board of directors; provided, however, that nothing in this Section 9 shall relieve the Company of its
obligations hereunder (or allow the Company to delay in its performance of its obligations hereunder) to provide indemnification for or make any Expense Advances with respect to the 

  
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Expenses of any Claim. To the extent the Company maintains liability insurance applicable to directors, officers or fiduciaries, Indemnitee shall be covered by such policies in such a manner as
to provide Indemnitee the same rights and benefits as are provided to the most favorably insured of the Company’s directors, if Indemnitee is a director; or of the Company’s officers, if Indemnitee is not a director of the Company but is
an officer. The Company shall promptly notify Indemnitee of any expiration, lapse, non-renewal or denial of coverage under any such policy. 

10. EXCEPTIONS. 

(a) Excluded Action or Omissions. The Company will not indemnify Indemnitee for Expenses resulting from acts, omissions or transactions
for which Indemnitee is prohibited from receiving indemnification under this Agreement or applicable law; provided, however, that notwithstanding any limitation set forth in this subsection (a) regarding the Company’s obligation to
provide indemnification, Indemnitee will be entitled under Section 3 to receive Expense Advances hereunder with respect to any such Claim unless and until a court having jurisdiction over the Claim will have made a final judicial determination
(as to which all rights of appeal therefrom have been exhausted or lapsed) that Indemnitee has engaged in acts, omissions or transactions for which Indemnitee is prohibited from receiving indemnification under this Agreement or applicable law. 

(b) Claims Initiated by Indemnitee. The Company will not indemnify or make Expense Advances to Indemnitee with respect to Claims
initiated or brought voluntarily by Indemnitee and not by way of defense, counterclaim or cross claim, except (i) with respect to actions or proceedings brought to establish or enforce a right to indemnification under this Agreement or any
other agreement or insurance policy or under the Company’s certificate of incorporation or bylaws now or hereafter in effect relating to Claims for Covered Events, (ii) in specific cases if the Board of Directors has approved the
initiation or bringing of such Claim, or (iii) as otherwise required under Section 145 of the Delaware General Corporation Law (relating to indemnification of officers, directors, employees and agents; and insurance), regardless of whether
Indemnitee ultimately is determined to be entitled to such indemnification or insurance recovery, as the case may be. 
 (c) Lack of Good
Faith. The Company will not indemnify Indemnitee for any Expenses incurred by the Indemnitee with respect to any action in which the Indemnitee has been finally adjudged by a court having jurisdiction in the matter (i) to have acted in bad
faith; (ii) to not have acted in a manner Indemnitee reasonably believed to be in or not opposed to the best interests of the Company; or (iii) with respect to criminal actions or proceedings, to have had reasonable cause to believe
Indemnitee’s conduct was unlawful. 
 (d) Claims Under Section 16(b). The Company will not indemnify Indemnitee for
Expenses and the payment of profits arising from the purchase and sale by Indemnitee of securities in violation of Section 16(b) of the Securities Exchange Act of 1934, as amended, or any similar successor statute; provided, however,
that notwithstanding any limitation set forth in this subsection (d) regarding the Company’s obligation to provide indemnification, Indemnitee shall be entitled under Section 3 to receive Expense Advances hereunder with respect to any
such Claim unless and until a court having jurisdiction over the Claim will have made a final judicial determination (as to which all rights of appeal therefrom have been exhausted or lapsed) that Indemnitee has violated said statute. 

(e) Clawback Under Sarbanes-Oxley Act. The Company will not indemnify Indemnitee in connection with any Claim for reimbursement of the
Company by Indemnitee of any bonus or other incentive-based or equity-based compensation or of any profits realized by Indemnitee from the sale of securities of the Company, as required in each case under the Securities Exchange Act of 1934, as
amended (including any such reimbursements that arise from an accounting restatement of the Company 

  
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pursuant to Section 304 of the Sarbanes-Oxley Act of 2002 (the “Sarbanes-Oxley Act”), or the payment to the Company of profits arising from the purchase and sale by
Indemnitee of securities in violation of Section 306 of the Sarbanes-Oxley Act), if Indemnitee is held liable therefor (including pursuant to any settlement). 

11. COUNTERPARTS. This Agreement may be executed in one or more counterparts, each of which will be an original, but all
of which together will constitute one instrument. 
 12. BINDING EFFECT; SUCCESSORS
AND ASSIGNS. This Agreement will be binding upon and inure to the benefit of and be enforceable by the parties hereto and their respective successors, assigns (including any direct or indirect successor by purchase,
merger, consolidation or otherwise to all or substantially all of the business or assets of the Company), spouses, heirs and personal and legal representatives. The Company shall require and cause any successor (whether direct or indirect, and
whether by purchase, merger, consolidation or otherwise) to all, substantially all, or a substantial part, of the business or assets of the Company, by written agreement in form and substance satisfactory to Indemnitee, expressly to assume and agree
to perform this Agreement in the same manner and to the same extent that the Company would be required to perform if no such succession had taken place. This Agreement will continue in effect regardless of whether Indemnitee continues to serve as a
director, officer, employee, agent or fiduciary (as applicable) of the Company or of any other enterprise at the Company’s request, but only with respect to Covered Events. 

13. EXPENSES INCURRED IN ACTION RELATING TO
ENFORCEMENT OR INTERPRETATION. In the event that any action is instituted by Indemnitee under this Agreement or under any liability insurance policies maintained by the Company to enforce or interpret
any of the terms hereof or thereof, Indemnitee shall be entitled to be indemnified for all Expenses incurred by Indemnitee with respect to such action (including without limitation attorneys’ fees), regardless of whether Indemnitee is
ultimately successful in such action, unless as a part of such action a court having jurisdiction over such action makes a final judicial determination (as to which all rights of appeal therefrom have been exhausted or lapsed) that each of the
material assertions made by Indemnitee as a basis for such action was not made in good faith or was frivolous; provided, however, that until such final judicial determination is made, Indemnitee shall be entitled under Section 3 to
receive payment of Expense Advances hereunder with respect to such action. In the event of an action instituted by or in the name of the Company under this Agreement to enforce or interpret any of the terms of this Agreement, Indemnitee shall be
entitled to be indemnified for all Expenses incurred by Indemnitee in defense of such action (including without limitation costs and expenses incurred with respect to Indemnitee’s counterclaims and cross-claims made in such action), unless as a
part of such action a court having jurisdiction over such action makes a final judicial determination (as to which all rights of appeal therefrom have been exhausted or lapsed) that each of the material defenses asserted by Indemnitee in such action
was made in bad faith or was frivolous; provided, however, that until such final judicial determination is made, Indemnitee shall be entitled under Section 3 to receive payment of Expense Advances hereunder with respect to such action.

 14. NOTICES. All notices required or permitted hereunder shall be in writing and shall be deemed effectively given:
(a) upon personal delivery to the party to be notified, (b) when sent by confirmed electronic mail or facsimile if sent during normal business hours of the recipient; if not, then on the next business day, (c) five days after having
been sent by registered or certified mail, return receipt requested, postage prepaid, or (d) one day after deposit with a nationally recognized overnight courier, specifying next day delivery, with written verification of receipt. Addresses for
notice to either party are as shown on the signature page of this Agreement or as subsequently modified by written notice. 

  
 9 

 15. CONSENT TO JURISDICTION. The Company and
Indemnitee each hereby irrevocably consent to the jurisdiction of the courts of the State of Delaware for all purposes in connection with any action or proceeding which arises out of or relates to this Agreement and agree that any action instituted
under this Agreement will be commenced, prosecuted and continued only in the Court of Chancery of the State of Delaware in and for New Castle County, which will be the exclusive and only proper forum for adjudicating such a claim. 

16. CHOICE OF LAW. This Agreement will be governed by and construed under the laws of the
State of Delaware in all respects as such laws are applied to agreements among Delaware residents entered into and performed entirely within Delaware, without giving effect to conflict of law principles thereof. 

17. SEVERABILITY. In the event one or more of the provisions of this Agreement should, for any reason, be held to be
invalid, illegal or unenforceable in any respect, such invalidity, illegality or unenforceability will not affect any other provisions of this Agreement, and this Agreement will be construed as if such invalid, illegal or unenforceable provision had
never been contained herein. 
 18. SUBROGATION. Subject to Section 5(c) above, in the event of payment under
this Agreement, the Company shall be subrogated to the extent of such payment to all of the rights of recovery of Indemnitee, who shall execute all documents required and shall do all acts that may be necessary to secure such rights and to enable
the Company effectively to bring suit to enforce such rights. 
 19. AMENDMENT AND
WAIVER. No amendment, modification, termination or cancellation of this Agreement will be effective unless it is in writing signed by both the parties hereto. No waiver of any of the provisions of this Agreement will be deemed to
be or will constitute a waiver of any other provisions hereof (whether or not similar), nor will such waiver constitute a continuing waiver. 

20. INTEGRATION; ENTIRE AGREEMENT. This Agreement sets forth the entire understanding
between the parties hereto and supersedes and merges all previous written and oral negotiations, commitments, understandings and agreements between the parties relating to the subject matter contained in this Agreement. 

21. HEADINGS. The section and subsection headings contained in this Agreement are for reference purposes only and will
not affect in any way the meaning or interpretation of this Agreement. 
 22. NO CONSTRUCTION
AS EMPLOYMENT AGREEMENT. Nothing contained in this Agreement will be construed as giving Indemnitee any right to be retained in the employ of the Company or any of its subsidiaries or affiliated
entities. 

  
 10 

 The parties have executed this Indemnification Agreement as of the date first above written. 

 

			
	VERSARTIS, INC.
		
	By:	 	 
		 	Jeffrey L. Cleland
		 	President and Chief Executive Officer

  

			
	 AGREED TO AND ACCEPTED BY:

INDEMNITEE:

	
	 
	Signature of Indemnitee
	
	 
	Print or Type Name of Indemnitee
		
	Address:	 	 
		
		 	 

 INDEMNIFICATION AGREEMENTEX-10.21

 Exhibit 10.21 

AMENDMENT NO. 2 TO SECOND AMENDED AND RESTATED LICENSING AGREEMENT 

This Amendment No. 2 (“Amendment No. 2”) to the Second Amended and Restated Licensing Agreement dated
December 30, 2010, as amended February 3, 2011, and as amended by Amendment No. 1 (“Amendment No.1”) as of the Amendment No. 1 Effective Date (as defined therein) (the “Agreement”) is entered
into by and between Amunix Operating, Inc. (“Licensor”) and Versartis, Inc. (“Licensee”) as of February 25, 2014 (the “Effective Date”). 

WHEREAS, the parties desire to amend the Agreement as of the Effective Date as set forth in this Amendment No. 2. 

NOW, THEREFORE, in exchange for good and valuable consideration, receipt of which is hereby acknowledged, the Licensor and Licensee agree as
follows: 
 1. Definitions. Capitalized terms not otherwise defined in this Amendment No. 2 shall have the same meaning as in
the Agreement, as amended hereby. 
 2. Amendments. The Agreement is hereby amended as follows: 

a. Definition of Covered Product. Section 1.6 of Amendment No. 1 is hereby deleted in its entirety and replaced by the
following: 
 1.6 “Covered Product” means a specific composition of matter that: (a) consists of a specific set of
modifications to a single Selected Target, including without limitations deletions, substitutions, fusions or fragments of such Selected Target, to which an rPEG molecule has been attached, (b) is created using or is otherwise Covered by the
rPEG Licensed IP, and (iii) is selected for clinical development by Licensee (or a sub-licenseeor any further sub-licensee thereof). 

b. Definition of Selected Target. Section 1.20 of the Agreement is hereby deleted in its entirety and replaced by the following:

 1.20 “Selected Target” means a Target that Licensee has selected (a) pursuant to the Original License as set forth in
Section 2.1 or (b) pursuant to Section 2.4 or 2.5, below, for the development of Covered Products and, if applicable, Marketed Products. 

c. License Grant. Section 2(i) of Amendment No. 1 is hereby restated as follows: 

i. Section 2.6(a) of the Agreement is hereby deleted in its entirety and replaced by the following: 

(a) Grant of Rights. Licensee is hereby granted a worldwide, exclusive, irrevocable (except as set forth in Section 5.2, below),
sub-licensable right and license under the rPEG Licensed IP to research, develop, make, have made and use Covered Products 

 
and to make, have made, use, sell, offer for sale, import, export, and otherwise fully exploit up to four specific Marketed Products in the Field. For purposes of clarification, Licensee shall
not have any rights to the rPEG Licensed IP except as set forth in this Section 2.6 and in each case subject to Section 2.8, below. The foregoing grant of rights shall be subject to: (i) the retained rights of the U.S. Government
under 35 U.S.C. §200 et seq. and 37 C.F.R. §401, if any, and (ii) an obligation under 35 U.S.C. §204, if applicable, that Covered Products and Marketed Products be manufactured substantially in the United States, unless a
waiver is obtained from the appropriate federal agency. At Licensee’s request, Licensor will apply for such waiver of the U.S. manufacturing requirements with respect to the Covered Products and Marketed Products and will use reasonable efforts
to obtain such waiver. Licensee shall cooperate with Licensor and provide reasonably necessary information in support of such waiver application if Licensor so requests. Licensor agrees that upon request of Licensee, Licensor will apply for a waiver
of the U.S. manufacturing requirements set forth in 37 C.F.R. §401 with respect to the Covered Products and will use reasonable efforts to obtain such waiver. Licensee shall cooperate with Licensor and provide reasonably necessary information
in support of such efforts to obtain such waiver if Licensor so requests. 
 d. Cross-References. In Section 2(j) of Amendment
No. 1, relating to Section 4.1(a) of the Agreement, the reference to “Section 2.5” in the last line is hereby deleted and replaced with a reference to “Section 2.6(a).” In Section 3.3(b) of the Agreement (from the
Amended and Restated Licensing Agreement of July 15, 2010), the reference to “Section 2.7(b)” in the second line is hereby deleted and replaced with a reference to “Section 2.6(b).” 

3. No Other Amendments. No amendments are made other than those expressly set forth in this Amendment No. 2, and all provisions of
the Agreement unaffected by this Amendment No. 2 remain in full force and effect. In the event of a conflict between the Agreement and this Amendment No. 2, this Amendment No. 2 shall control. 

4. Entire Agreement. This Amendment No. 2 sets forth the entire agreement and understanding between the Parties with respect to
the subject matter hereof and supersedes all previous agreements, promises, representations, understandings and negotiations, whether written or oral, between the Parties, with respect thereto. 

5. Governing Law. This Amendment No. 2 shall be governed by the Laws of the State of California, without reference to conflict of
laws principles. 
 6. Counterparts. This Amendment No. 2 may be executed in two or more counterparts, each of which shall
constitute an original, and all of which together shall constitute a single instrument. Signatures to this Amendment No. 2 transmitted by facsimile, by electronic mail in .pdf (portable document format) form, or by any other electronic means
intended to preserve the original graphic and pictorial appearance of this Amendment No. 2, shall have the same effect as physical delivery of the paper Amendment No. 2 bearing the original signature. 

[Signature page follows] 

  
 2 

 IN WITNESS WHEREOF, each party by its designated authority has executed this Amendment No. 2
effective as of the Effective Date. 
  

									
	AMUNIX OPERATING, INC.	 		 	VERSARTIS, INC.
					
	By:	 	/s/ Volker Schellenberger	 		 	By:	 	/s/ Jeffrey L. Cleland
					
	Name:	 	Volker Schellenberger	 		 	Name:	 	Jeffrey L. Cleland
					
	Title:	 	President and CEO	 		 	Title:	 	CEO

  
  
  

 
 Signature Page to Amendment No. 2 to Second Amended and Restated
Licensing Agreement

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